assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	1	287215-288600	1	CRT	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	NCAACAGGNGCAACAGGN	18	4	12	287512-287529|287512-287529|288214-288240|288259-288276|288565-288582|288565-288582|288565-288582|288565-288582|288565-288582|288565-288582|288565-288582|288565-288582	NZ_CP019870.1_405415-405432|NZ_CP019870.1_405793-405810|NZ_CP019870.1_406126-406152|NZ_CP019870.1_3642197-3642180|NZ_CP019870.1_3642728-3642711|NZ_CP019870.1_406135-406152|NZ_CP019870.1_406234-406251|NZ_CP019870.1_3642161-3642144|NZ_CP019870.1_3642188-3642171|NZ_CP019870.1_3642422-3642405|NZ_CP019870.1_3642629-3642612|NZ_CP019870.1_3642692-3642675	NA	28	28	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA,NA|125aa|down_7|NZ_CP019870.1_295020_295395_+,NA|570aa|down_8|NZ_CP019870.1_295477_297187_+	NA|513aa|up_9|NZ_CP019870.1_277464_279003_-	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]	NA|152aa|up_8|NZ_CP019870.1_279884_280340_+	COG1522, Lrp, Transcriptional regulators [Transcription]	NA|195aa|up_7|NZ_CP019870.1_280388_280973_+	cd03135, GATase1_DJ-1, Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1	NA|108aa|up_6|NZ_CP019870.1_280977_281301_-	COG1733, COG1733, Predicted transcriptional regulators [Transcription]	NA|173aa|up_5|NZ_CP019870.1_281452_281971_+	cd20609, nitroreductase, nitroreductase family protein	NA|223aa|up_4|NZ_CP019870.1_282146_282815_-	COG3382, COG3382, Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]	NA|472aa|up_3|NZ_CP019870.1_282929_284345_+	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]	NA|153aa|up_2|NZ_CP019870.1_284567_285026_+	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription]	NA|195aa|up_1|NZ_CP019870.1_285022_285607_+	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed	NA|359aa|up_0|NZ_CP019870.1_285918_286995_+	cd02511, Beta4Glucosyltransferase, UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide	NA|254aa|down_0|NZ_CP019870.1_289296_290058_+	COG1600, COG1600, Uncharacterized Fe-S protein [Energy production and conversion]	NA|93aa|down_1|NZ_CP019870.1_290366_290645_+	pfam08765, Mor, Mor transcription activator family	NA|192aa|down_2|NZ_CP019870.1_290937_291513_+	pfam06353, DUF1062, Protein of unknown function (DUF1062)	NA|237aa|down_3|NZ_CP019870.1_291951_292662_+	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]	NA|439aa|down_4|NZ_CP019870.1_292655_293972_+	cd16935, HATPase_AgrC-ComD-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing	NA|47aa|down_5|NZ_CP019870.1_293983_294124_+	TIGR04223, quorum_AgrD, cyclic lactone autoinducer peptide	NA|194aa|down_6|NZ_CP019870.1_294182_294764_+	pfam04647, AgrB, Accessory gene regulator B	NA|125aa|down_7|NZ_CP019870.1_295020_295395_+	NA	NA|570aa|down_8|NZ_CP019870.1_295477_297187_+	NA	NA|291aa|down_9|NZ_CP019870.1_297201_298074_+	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	2	752098-753899	1,1,2	PILER-CR,CRISPRCasFinder,CRT	no	WYL,cas6,cas8b2,cas7,cas5,cas3,cas4,cas1,cas2	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Unclear	GTTTTATATTAACTAAGTGGTATGTAAAT,GTTTTATATTAACTAAGTGGTATGTAAAT,GTTTTATATTAACTAAGTGGTATGTAAAT	29,29,29	0	0	NA	NA	I-A:I-A:I-A	26,26,27	27	Unclear	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA,NA|260aa|down_1|NZ_CP019870.1_754970_755750_-,NA|67aa|down_7|NZ_CP019870.1_760932_761133_-	NA|639aa|up_9|NZ_CP019870.1_740334_742251_+	pfam02687, FtsX, FtsX-like permease family	WYL|306aa|up_8|NZ_CP019870.1_742529_743447_+	pfam13280, WYL, WYL domain	cas6|246aa|up_7|NZ_CP019870.1_743524_744262_+	cd09652, Cas6-I-III, CRISPR/Cas system-associated RAMP superfamily protein Cas6	cas8b2|626aa|up_6|NZ_CP019870.1_744267_746145_+	cd09665, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1	cas7|305aa|up_5|NZ_CP019870.1_746146_747061_+	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7	cas5|234aa|up_4|NZ_CP019870.1_747062_747764_+	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5	cas3|774aa|up_3|NZ_CP019870.1_747774_750096_+	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3	cas4|184aa|up_2|NZ_CP019870.1_750110_750662_+	pfam01930, Cas_Cas4, Domain of unknown function DUF83	cas1|327aa|up_1|NZ_CP019870.1_750664_751645_+	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP	cas2|89aa|up_0|NZ_CP019870.1_751647_751914_+	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2	NA|143aa|down_0|NZ_CP019870.1_754087_754516_+	PRK10562, PRK10562, putative acetyltransferase; Provisional	NA|260aa|down_1|NZ_CP019870.1_754970_755750_-	NA	NA|182aa|down_2|NZ_CP019870.1_756073_756619_+	pfam02632, BioY, BioY family	NA|379aa|down_3|NZ_CP019870.1_756650_757787_+	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine	NA|464aa|down_4|NZ_CP019870.1_757790_759182_+	cd17633, AFD_YhfT-like, fatty acid-CoA ligase VraA	NA|292aa|down_5|NZ_CP019870.1_759257_760133_+	PRK08306, PRK08306, dipicolinate synthase subunit DpsA	NA|197aa|down_6|NZ_CP019870.1_760135_760726_+	PRK08305, spoVFB, dipicolinate synthase subunit B; Reviewed	NA|67aa|down_7|NZ_CP019870.1_760932_761133_-	NA	NA|885aa|down_8|NZ_CP019870.1_761636_764291_+	PRK13805, PRK13805, bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional	NA|740aa|down_9|NZ_CP019870.1_764566_766786_+	cd01948, EAL, EAL domain
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	3	753935-754027	2	CRISPRCasFinder	no	WYL,cas6,cas8b2,cas7,cas5,cas3,cas4,cas1,cas2	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Unclear	GTTTTATATTAACTAAGTGGTATGTAAAT	29	0	0	NA	NA	I-A	1	1	Unclear	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA,NA|260aa|down_1|NZ_CP019870.1_754970_755750_-,NA|67aa|down_7|NZ_CP019870.1_760932_761133_-	NA|639aa|up_9|NZ_CP019870.1_740334_742251_+	pfam02687, FtsX, FtsX-like permease family	WYL|306aa|up_8|NZ_CP019870.1_742529_743447_+	pfam13280, WYL, WYL domain	cas6|246aa|up_7|NZ_CP019870.1_743524_744262_+	cd09652, Cas6-I-III, CRISPR/Cas system-associated RAMP superfamily protein Cas6	cas8b2|626aa|up_6|NZ_CP019870.1_744267_746145_+	cd09665, Cas8a1_I-A, CRISPR/Cas system-associated protein Cas8a1	cas7|305aa|up_5|NZ_CP019870.1_746146_747061_+	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7	cas5|234aa|up_4|NZ_CP019870.1_747062_747764_+	cd09658, Cas5_I-B, CRISPR/Cas system-associated RAMP superfamily protein Cas5	cas3|774aa|up_3|NZ_CP019870.1_747774_750096_+	TIGR01587, CRISPR-associated_endonuclease/helicase_Cas3, CRISPR-associated helicase Cas3	cas4|184aa|up_2|NZ_CP019870.1_750110_750662_+	pfam01930, Cas_Cas4, Domain of unknown function DUF83	cas1|327aa|up_1|NZ_CP019870.1_750664_751645_+	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP	cas2|89aa|up_0|NZ_CP019870.1_751647_751914_+	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2	NA|143aa|down_0|NZ_CP019870.1_754087_754516_+	PRK10562, PRK10562, putative acetyltransferase; Provisional	NA|260aa|down_1|NZ_CP019870.1_754970_755750_-	NA	NA|182aa|down_2|NZ_CP019870.1_756073_756619_+	pfam02632, BioY, BioY family	NA|379aa|down_3|NZ_CP019870.1_756650_757787_+	cd00751, thiolase, Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine	NA|464aa|down_4|NZ_CP019870.1_757790_759182_+	cd17633, AFD_YhfT-like, fatty acid-CoA ligase VraA	NA|292aa|down_5|NZ_CP019870.1_759257_760133_+	PRK08306, PRK08306, dipicolinate synthase subunit DpsA	NA|197aa|down_6|NZ_CP019870.1_760135_760726_+	PRK08305, spoVFB, dipicolinate synthase subunit B; Reviewed	NA|67aa|down_7|NZ_CP019870.1_760932_761133_-	NA	NA|885aa|down_8|NZ_CP019870.1_761636_764291_+	PRK13805, PRK13805, bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional	NA|740aa|down_9|NZ_CP019870.1_764566_766786_+	cd01948, EAL, EAL domain
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	4	857463-857674	3	CRISPRCasFinder	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	AATCCACCAGTACCACCATCAGAAGA	26	0	0	NA	NA	NA	3	3	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA,NA|459aa|down_6|NZ_CP019870.1_864770_866147_-	NA|424aa|up_9|NZ_CP019870.1_840124_841396_+	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional	NA|502aa|up_8|NZ_CP019870.1_841856_843362_+	cd16956, HATPase_YehU-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU	NA|233aa|up_7|NZ_CP019870.1_843475_844174_+	cd17536, REC_YesN-like, phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators	NA|363aa|up_6|NZ_CP019870.1_844458_845547_+	COG3949, COG3949, Uncharacterized membrane protein [Function unknown]	NA|397aa|up_5|NZ_CP019870.1_845785_846976_+	cd03886, M20_Acy1, M20 Peptidase Aminoacylase 1 family	NA|501aa|up_4|NZ_CP019870.1_847066_848569_+	COG2978, AbgT, Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]	NA|419aa|up_3|NZ_CP019870.1_848640_849897_+	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed	NA|925aa|up_2|NZ_CP019870.1_850068_852843_+	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism]	NA|50aa|up_1|NZ_CP019870.1_852943_853093_-	cd04335, PrdX_deacylase, This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences	NA|393aa|up_0|NZ_CP019870.1_853467_854646_+	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]	NA|221aa|down_0|NZ_CP019870.1_858263_858926_+	cd20183, M34_PPEP, Pro-Pro endopeptidase (PPEP) and similar proteins; belongs to peptidase family M34	NA|321aa|down_1|NZ_CP019870.1_859047_860010_-	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter	NA|397aa|down_2|NZ_CP019870.1_860179_861370_-	PRK06836, PRK06836, pyridoxal phosphate-dependent aminotransferase	NA|149aa|down_3|NZ_CP019870.1_861675_862122_+	COG1846, MarR, Transcriptional regulators [Transcription]	NA|365aa|down_4|NZ_CP019870.1_862123_863218_+	cd02803, OYE_like_FMN_family, Old yellow enzyme (OYE)-like FMN binding domain	NA|177aa|down_5|NZ_CP019870.1_863305_863836_+	pfam12641, Flavodoxin_3, Flavodoxin domain	NA|459aa|down_6|NZ_CP019870.1_864770_866147_-	NA	NA|391aa|down_7|NZ_CP019870.1_866415_867588_+	cd03885, M20_CPDG2, M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme	NA|216aa|down_8|NZ_CP019870.1_867601_868249_+	COG3314, COG3314, Uncharacterized protein conserved in bacteria [Function unknown]	NA|170aa|down_9|NZ_CP019870.1_868250_868760_+	PRK10519, PRK10519, hypothetical protein; Provisional
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	5	966720-966810	4	CRISPRCasFinder	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	ATATGTTTAGAAGCTGTAAAAAAA	24	0	0	NA	NA	NA	1	1	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|222aa|up_0|NZ_CP019870.1_965449_966115_-,NA	NA|302aa|up_9|NZ_CP019870.1_951437_952343_+	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3	NA|516aa|up_8|NZ_CP019870.1_952658_954206_+	cd01948, EAL, EAL domain	NA|133aa|up_7|NZ_CP019870.1_954208_954607_+	COG1959, COG1959, Predicted transcriptional regulator [Transcription]	NA|578aa|up_6|NZ_CP019870.1_954646_956380_+	NF033452, BREX_1_MTaseX, BREX-1 system adenine-specific DNA-methyltransferase PglX	NA|404aa|up_5|NZ_CP019870.1_956611_957823_+	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli	NA|87aa|up_4|NZ_CP019870.1_958016_958277_+	pfam00381, PTS-HPr, PTS HPr component phosphorylation site	NA|571aa|up_3|NZ_CP019870.1_958630_960343_+	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]	NA|517aa|up_2|NZ_CP019870.1_960665_962216_+	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain	NA|901aa|up_1|NZ_CP019870.1_962241_964944_+	cd01948, EAL, EAL domain	NA|222aa|up_0|NZ_CP019870.1_965449_966115_-	NA	NA|193aa|down_0|NZ_CP019870.1_968256_968835_+	pfam04647, AgrB, Accessory gene regulator B	NA|49aa|down_1|NZ_CP019870.1_968864_969011_+	TIGR04223, quorum_AgrD, cyclic lactone autoinducer peptide	NA|460aa|down_2|NZ_CP019870.1_969315_970695_+	TIGR03974, six-Cys-in-45_modification_radical_SAM_protein, SCIFF radical SAM maturase	NA|166aa|down_3|NZ_CP019870.1_970723_971221_+	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E	NA|555aa|down_4|NZ_CP019870.1_971518_973183_+	COG0661, AarF, Predicted unusual protein kinase [General function prediction only]	NA|817aa|down_5|NZ_CP019870.1_973195_975646_+	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ	NA|171aa|down_6|NZ_CP019870.1_975658_976171_+	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional	NA|736aa|down_7|NZ_CP019870.1_976244_978452_+	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]	NA|150aa|down_8|NZ_CP019870.1_978476_978926_+	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional	NA|205aa|down_9|NZ_CP019870.1_978940_979555_+	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	6	967014-967302	5	CRISPRCasFinder	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	ATATGTTTAGAAGCTGTAAAAAAA	24	0	0	NA	NA	NA	4	4	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|222aa|up_0|NZ_CP019870.1_965449_966115_-,NA	NA|302aa|up_9|NZ_CP019870.1_951437_952343_+	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3	NA|516aa|up_8|NZ_CP019870.1_952658_954206_+	cd01948, EAL, EAL domain	NA|133aa|up_7|NZ_CP019870.1_954208_954607_+	COG1959, COG1959, Predicted transcriptional regulator [Transcription]	NA|578aa|up_6|NZ_CP019870.1_954646_956380_+	NF033452, BREX_1_MTaseX, BREX-1 system adenine-specific DNA-methyltransferase PglX	NA|404aa|up_5|NZ_CP019870.1_956611_957823_+	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli	NA|87aa|up_4|NZ_CP019870.1_958016_958277_+	pfam00381, PTS-HPr, PTS HPr component phosphorylation site	NA|571aa|up_3|NZ_CP019870.1_958630_960343_+	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]	NA|517aa|up_2|NZ_CP019870.1_960665_962216_+	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain	NA|901aa|up_1|NZ_CP019870.1_962241_964944_+	cd01948, EAL, EAL domain	NA|222aa|up_0|NZ_CP019870.1_965449_966115_-	NA	NA|193aa|down_0|NZ_CP019870.1_968256_968835_+	pfam04647, AgrB, Accessory gene regulator B	NA|49aa|down_1|NZ_CP019870.1_968864_969011_+	TIGR04223, quorum_AgrD, cyclic lactone autoinducer peptide	NA|460aa|down_2|NZ_CP019870.1_969315_970695_+	TIGR03974, six-Cys-in-45_modification_radical_SAM_protein, SCIFF radical SAM maturase	NA|166aa|down_3|NZ_CP019870.1_970723_971221_+	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E	NA|555aa|down_4|NZ_CP019870.1_971518_973183_+	COG0661, AarF, Predicted unusual protein kinase [General function prediction only]	NA|817aa|down_5|NZ_CP019870.1_973195_975646_+	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ	NA|171aa|down_6|NZ_CP019870.1_975658_976171_+	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional	NA|736aa|down_7|NZ_CP019870.1_976244_978452_+	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]	NA|150aa|down_8|NZ_CP019870.1_978476_978926_+	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional	NA|205aa|down_9|NZ_CP019870.1_978940_979555_+	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	7	967410-967583	6	CRISPRCasFinder	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	ATATGTTTAGAAGCTGTAAAAAAA	24	0	0	NA	NA	NA	2	2	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|222aa|up_0|NZ_CP019870.1_965449_966115_-,NA	NA|302aa|up_9|NZ_CP019870.1_951437_952343_+	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3	NA|516aa|up_8|NZ_CP019870.1_952658_954206_+	cd01948, EAL, EAL domain	NA|133aa|up_7|NZ_CP019870.1_954208_954607_+	COG1959, COG1959, Predicted transcriptional regulator [Transcription]	NA|578aa|up_6|NZ_CP019870.1_954646_956380_+	NF033452, BREX_1_MTaseX, BREX-1 system adenine-specific DNA-methyltransferase PglX	NA|404aa|up_5|NZ_CP019870.1_956611_957823_+	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli	NA|87aa|up_4|NZ_CP019870.1_958016_958277_+	pfam00381, PTS-HPr, PTS HPr component phosphorylation site	NA|571aa|up_3|NZ_CP019870.1_958630_960343_+	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]	NA|517aa|up_2|NZ_CP019870.1_960665_962216_+	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain	NA|901aa|up_1|NZ_CP019870.1_962241_964944_+	cd01948, EAL, EAL domain	NA|222aa|up_0|NZ_CP019870.1_965449_966115_-	NA	NA|193aa|down_0|NZ_CP019870.1_968256_968835_+	pfam04647, AgrB, Accessory gene regulator B	NA|49aa|down_1|NZ_CP019870.1_968864_969011_+	TIGR04223, quorum_AgrD, cyclic lactone autoinducer peptide	NA|460aa|down_2|NZ_CP019870.1_969315_970695_+	TIGR03974, six-Cys-in-45_modification_radical_SAM_protein, SCIFF radical SAM maturase	NA|166aa|down_3|NZ_CP019870.1_970723_971221_+	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E	NA|555aa|down_4|NZ_CP019870.1_971518_973183_+	COG0661, AarF, Predicted unusual protein kinase [General function prediction only]	NA|817aa|down_5|NZ_CP019870.1_973195_975646_+	TIGR00644, recJ, single-stranded-DNA-specific exonuclease RecJ	NA|171aa|down_6|NZ_CP019870.1_975658_976171_+	PRK02304, PRK02304, adenine phosphoribosyltransferase; Provisional	NA|736aa|down_7|NZ_CP019870.1_976244_978452_+	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]	NA|150aa|down_8|NZ_CP019870.1_978476_978926_+	PRK05273, PRK05273, D-tyrosyl-tRNA(Tyr) deacylase; Provisional	NA|205aa|down_9|NZ_CP019870.1_978940_979555_+	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	8	1022152-1022477	7	CRISPRCasFinder	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	ACAGGATGGCAAGAAATAGATGGTAA	26	0	0	NA	NA	NA	5	5	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|458aa|up_7|NZ_CP019870.1_1004826_1006200_+,NA|664aa|up_3|NZ_CP019870.1_1016986_1018978_+,NA|107aa|up_2|NZ_CP019870.1_1018967_1019288_+,NA	NA|235aa|up_9|NZ_CP019870.1_1002641_1003346_+	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|441aa|up_8|NZ_CP019870.1_1003338_1004661_+	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|458aa|up_7|NZ_CP019870.1_1004826_1006200_+	NA	NA|313aa|up_6|NZ_CP019870.1_1006571_1007510_-	cd10948, CE4_BsPdaA_like, Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs	NA|226aa|up_5|NZ_CP019870.1_1012899_1013577_-	cd05826, Sortase_B, Sortase domain found in class B sortases	NA|848aa|up_4|NZ_CP019870.1_1014320_1016864_+	PTZ00121, PTZ00121, MAEBL; Provisional	NA|664aa|up_3|NZ_CP019870.1_1016986_1018978_+	NA	NA|107aa|up_2|NZ_CP019870.1_1018967_1019288_+	NA	NA|290aa|up_1|NZ_CP019870.1_1019485_1020355_+	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]	NA|338aa|up_0|NZ_CP019870.1_1020378_1021392_+	PLN02240, PLN02240, UDP-glucose 4-epimerase	NA|288aa|down_0|NZ_CP019870.1_1023592_1024456_+	cd01027, TOPRIM_RNase_M5_like, TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea	NA|294aa|down_1|NZ_CP019870.1_1024663_1025545_-	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold	NA|283aa|down_2|NZ_CP019870.1_1025957_1026806_+	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]	NA|641aa|down_3|NZ_CP019870.1_1026884_1028807_+	TIGR03997, NADH:flavin_oxidoreductase, mycofactocin system FadH/OYE family oxidoreductase 2	NA|288aa|down_4|NZ_CP019870.1_1028888_1029752_+	PRK12548, PRK12548, shikimate dehydrogenase	NA|406aa|down_5|NZ_CP019870.1_1029951_1031169_+	cd17396, MFS_YdiM_like, Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters	NA|622aa|down_6|NZ_CP019870.1_1031404_1033270_+	smart00910, HIRAN, The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p	NA|455aa|down_7|NZ_CP019870.1_1033447_1034812_-	cd01298, ATZ_TRZ_like, TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases	NA|448aa|down_8|NZ_CP019870.1_1034990_1036334_-	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]	NA|218aa|down_9|NZ_CP019870.1_1036836_1037490_+	COG1357, COG1357, Pentapeptide repeats containing protein [Function unknown]
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	9	1257179-1257737	2,8,3	PILER-CR,CRISPRCasFinder,CRT	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	GTTTTATATTAACTATATGGAATGTAAATT,GTTTTATATTAACTATATGGAATGTAAAT,GTTTTATATTAACTATATGGAATGTAAATT	30,29,30	0	0	NA	NA	I-A:I-A:I-A	8,8,8	8	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|53aa|up_0|NZ_CP019870.1_1256734_1256893_+,NA	NA|214aa|up_9|NZ_CP019870.1_1243345_1243987_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|668aa|up_8|NZ_CP019870.1_1244160_1246164_-	PLN02447, PLN02447, 1,4-alpha-glucan-branching enzyme	NA|213aa|up_7|NZ_CP019870.1_1246316_1246955_-	PRK00117, recX, recombination regulator RecX; Reviewed	NA|230aa|up_6|NZ_CP019870.1_1247230_1247920_+	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase	NA|191aa|up_5|NZ_CP019870.1_1247920_1248493_+	COG1713, COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]	NA|117aa|up_4|NZ_CP019870.1_1248609_1248960_+	pfam02410, RsfS, Ribosomal silencing factor during starvation	NA|807aa|up_3|NZ_CP019870.1_1249313_1251734_+	PRK00390, leuS, leucyl-tRNA synthetase; Validated	NA|223aa|up_2|NZ_CP019870.1_1252586_1253255_+	pfam04892, VanZ, VanZ like family	NA|457aa|up_1|NZ_CP019870.1_1255070_1256441_+	NF033435, S-layer_Clost, S-layer protein SlpA	NA|53aa|up_0|NZ_CP019870.1_1256734_1256893_+	NA	NA|332aa|down_0|NZ_CP019870.1_1258762_1259758_-	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase	NA|543aa|down_1|NZ_CP019870.1_1259878_1261507_-	TIGR03801, For_A_Pyridoxal-5-_Phosphate, aspartate 4-decarboxylase	NA|406aa|down_2|NZ_CP019870.1_1262165_1263383_+	PRK08198, PRK08198, threonine dehydratase; Provisional	NA|127aa|down_3|NZ_CP019870.1_1263477_1263858_+	TIGR00004, RutC_family_protein, reactive intermediate/imine deaminase	NA|161aa|down_4|NZ_CP019870.1_1264141_1264624_+	pfam00358, PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1	NA|272aa|down_5|NZ_CP019870.1_1264644_1265460_+	PRK09772, PRK09772, transcriptional antiterminator BglG; Provisional	NA|517aa|down_6|NZ_CP019870.1_1265510_1267061_+	TIGR02005, PTS-IIBC-alpha, PTS system, alpha-glucoside-specific IIBC component	NA|451aa|down_7|NZ_CP019870.1_1267157_1268510_+	cd05298, GH4_GlvA_pagL_like, Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases	NA|253aa|down_8|NZ_CP019870.1_1268640_1269399_+	COG2169, Ada, Adenosine deaminase [Nucleotide transport and metabolism]	NA|240aa|down_9|NZ_CP019870.1_1269445_1270165_+	pfam01841, Transglut_core, Transglutaminase-like superfamily
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	10	1500847-1501926	3,9,4	PILER-CR,CRISPRCasFinder,CRT	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	GTTTTAGATTAACTATATGGAATGTAAAT,GTTTTAGATTAACTATATGGAATGTAAAT,GTTTTAGATTAACTATATGGAATGTAAAT	29,29,29	0	0	NA	NA	I-A:I-A:I-A	15,16,16	16	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|57aa|up_6|NZ_CP019870.1_1494477_1494648_-,NA|85aa|up_3|NZ_CP019870.1_1498423_1498678_+,NA|108aa|up_2|NZ_CP019870.1_1498713_1499037_+,NA|51aa|up_1|NZ_CP019870.1_1499310_1499463_+,NA|51aa|down_0|NZ_CP019870.1_1502116_1502269_+,NA|54aa|down_1|NZ_CP019870.1_1503254_1503416_+,NA|155aa|down_2|NZ_CP019870.1_1503744_1504209_-,NA|106aa|down_3|NZ_CP019870.1_1504344_1504662_-,NA|67aa|down_4|NZ_CP019870.1_1505039_1505240_-,NA|138aa|down_5|NZ_CP019870.1_1505258_1505672_-	NA|67aa|up_9|NZ_CP019870.1_1493098_1493299_-	COG1476, COG1476, Predicted transcriptional regulators [Transcription]	NA|117aa|up_8|NZ_CP019870.1_1493300_1493651_-	pfam12676, DUF3796, Protein of unknown function (DUF3796)	NA|63aa|up_7|NZ_CP019870.1_1493812_1494001_+	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|57aa|up_6|NZ_CP019870.1_1494477_1494648_-	NA	NA|163aa|up_5|NZ_CP019870.1_1495036_1495525_-	COG2165, PulG, Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]	NA|125aa|up_4|NZ_CP019870.1_1496330_1496705_+	pfam03965, Penicillinase_R, Penicillinase repressor	NA|85aa|up_3|NZ_CP019870.1_1498423_1498678_+	NA	NA|108aa|up_2|NZ_CP019870.1_1498713_1499037_+	NA	NA|51aa|up_1|NZ_CP019870.1_1499310_1499463_+	NA	NA|308aa|up_0|NZ_CP019870.1_1499656_1500580_+	pfam09851, SHOCT, Short C-terminal domain	NA|51aa|down_0|NZ_CP019870.1_1502116_1502269_+	NA	NA|54aa|down_1|NZ_CP019870.1_1503254_1503416_+	NA	NA|155aa|down_2|NZ_CP019870.1_1503744_1504209_-	NA	NA|106aa|down_3|NZ_CP019870.1_1504344_1504662_-	NA	NA|67aa|down_4|NZ_CP019870.1_1505039_1505240_-	NA	NA|138aa|down_5|NZ_CP019870.1_1505258_1505672_-	NA	NA|78aa|down_6|NZ_CP019870.1_1505655_1505889_-	COG1476, COG1476, Predicted transcriptional regulators [Transcription]	NA|125aa|down_7|NZ_CP019870.1_1506107_1506482_+	pfam03965, Penicillinase_R, Penicillinase repressor	NA|231aa|down_8|NZ_CP019870.1_1507093_1507786_+	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|687aa|down_9|NZ_CP019870.1_1507981_1510042_+	cd16923, HATPase_VanS-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	11	1851001-1852212	4,10,5	PILER-CR,CRISPRCasFinder,CRT	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	GTTTTATATTAACTATATGGAATGTAAAT,GTTTTATATTAACTATATGGAATGTAAAT,GTTTTATATTAACTATATGGAATGTAAAT	29,29,29	0	0	NA	NA	I-A:I-A:I-A	17,18,18	18	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|188aa|up_9|NZ_CP019870.1_1838933_1839497_+,NA|567aa|up_8|NZ_CP019870.1_1839893_1841594_+,NA|206aa|up_7|NZ_CP019870.1_1841763_1842381_+,NA|95aa|down_0|NZ_CP019870.1_1852380_1852665_+,NA|58aa|down_1|NZ_CP019870.1_1852821_1852995_-	NA|188aa|up_9|NZ_CP019870.1_1838933_1839497_+	NA	NA|567aa|up_8|NZ_CP019870.1_1839893_1841594_+	NA	NA|206aa|up_7|NZ_CP019870.1_1841763_1842381_+	NA	NA|398aa|up_6|NZ_CP019870.1_1842741_1843935_+	PRK06635, PRK06635, aspartate kinase; Reviewed	NA|431aa|up_5|NZ_CP019870.1_1843952_1845245_+	cd06828, PLPDE_III_DapDC, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase	NA|220aa|up_4|NZ_CP019870.1_1845461_1846121_+	pfam03154, Atrophin-1, Atrophin-1 family	NA|362aa|up_3|NZ_CP019870.1_1846275_1847361_-	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only]	NA|239aa|up_2|NZ_CP019870.1_1847551_1848268_+	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]	NA|193aa|up_1|NZ_CP019870.1_1848325_1848904_+	pfam06962, rRNA_methylase, Putative rRNA methylase	NA|291aa|up_0|NZ_CP019870.1_1849297_1850170_+	COG1737, RpiR, Transcriptional regulators [Transcription]	NA|95aa|down_0|NZ_CP019870.1_1852380_1852665_+	NA	NA|58aa|down_1|NZ_CP019870.1_1852821_1852995_-	NA	NA|72aa|down_2|NZ_CP019870.1_1853435_1853651_-	COG3655, COG3655, Predicted transcriptional regulator [Transcription]	NA|156aa|down_3|NZ_CP019870.1_1853661_1854129_-	pfam11188, DUF2975, Protein of unknown function (DUF2975)	NA|233aa|down_4|NZ_CP019870.1_1855151_1855850_-	TIGR03502, lipase_Pla1_cef, extracellular lipase, Pla-1/cef family	NA|186aa|down_5|NZ_CP019870.1_1856107_1856665_+	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|121aa|down_6|NZ_CP019870.1_1857014_1857377_-	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins	NA|270aa|down_7|NZ_CP019870.1_1857810_1858620_-	cd04782, HTH_BltR, Helix-Turn-Helix DNA binding domain of the BltR transcription regulator	NA|208aa|down_8|NZ_CP019870.1_1858711_1859335_+	pfam13189, Cytidylate_kin2, Cytidylate kinase-like family	NA|442aa|down_9|NZ_CP019870.1_1859331_1860657_+	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	12	2226341-2227556	11,6,5	CRISPRCasFinder,CRT,PILER-CR	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	ATTTACATACCACTTAGTTAATATAAAAC,ATTTACATACCACTTAGTTAATATAAAAC,GTTTTATATTAACTAAGTGGTATGTAAAT	29,29,29	0	0	NA	NA	I-A:I-A:I-A	18,18,15	18	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|258aa|up_8|NZ_CP019870.1_2215801_2216575_-,NA|341aa|up_6|NZ_CP019870.1_2217481_2218504_-,NA|59aa|up_5|NZ_CP019870.1_2219078_2219255_+,NA|96aa|up_0|NZ_CP019870.1_2225644_2225932_-,NA	NA|242aa|up_9|NZ_CP019870.1_2214964_2215690_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|258aa|up_8|NZ_CP019870.1_2215801_2216575_-	NA	NA|296aa|up_7|NZ_CP019870.1_2216580_2217468_-	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component	NA|341aa|up_6|NZ_CP019870.1_2217481_2218504_-	NA	NA|59aa|up_5|NZ_CP019870.1_2219078_2219255_+	NA	NA|195aa|up_4|NZ_CP019870.1_2220357_2220942_-	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates	NA|615aa|up_3|NZ_CP019870.1_2221263_2223108_-	cd08579, GDPD_memb_like, Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases	NA|321aa|up_2|NZ_CP019870.1_2223401_2224364_-	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase	NA|184aa|up_1|NZ_CP019870.1_2224554_2225106_+	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain	NA|96aa|up_0|NZ_CP019870.1_2225644_2225932_-	NA	NA|424aa|down_0|NZ_CP019870.1_2228202_2229474_+	cd01303, GDEase, Guanine deaminase (GDEase)	NA|106aa|down_1|NZ_CP019870.1_2230057_2230375_+	pfam06865, DUF1255, Protein of unknown function (DUF1255)	NA|786aa|down_2|NZ_CP019870.1_2230460_2232818_-	cd02609, P-type_ATPase, uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7	NA|486aa|down_3|NZ_CP019870.1_2233240_2234698_-	PRK04366, PRK04366, aminomethyl-transferring glycine dehydrogenase subunit GcvPB	NA|825aa|down_4|NZ_CP019870.1_2234697_2237172_-	PRK00451, PRK00451, aminomethyl-transferring glycine dehydrogenase subunit GcvPA	NA|172aa|down_5|NZ_CP019870.1_2237977_2238493_-	pfam13787, HXXEE, Protein of unknown function with HXXEE motif	NA|577aa|down_6|NZ_CP019870.1_2239017_2240748_-	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion]	NA|329aa|down_7|NZ_CP019870.1_2241231_2242218_+	TIGR00545, Probable_lipoate-protein_ligase_A, lipoyltransferase and lipoate-protein ligase	NA|266aa|down_8|NZ_CP019870.1_2242528_2243326_+	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]	NA|200aa|down_9|NZ_CP019870.1_2243428_2244028_+	COG4110, COG4110, Uncharacterized protein involved in stress response [General function prediction only]
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	13	2402892-2404049	7,12,6	CRT,CRISPRCasFinder,PILER-CR	no	cas14j	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Unclear	ATTTACATTCCATATAGTTAATATAAAAC,ATTTACATTCCATATAGTTAATATAAAAC,GTTTTATATTAACTATATGGAATGTAAAT	29,29,29	0	0	NA	NA	I-A:I-A:I-A	17,16,15	17	TypeV	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|330aa|up_4|NZ_CP019870.1_2397068_2398058_-,NA|61aa|down_4|NZ_CP019870.1_2410457_2410640_+,NA|190aa|down_7|NZ_CP019870.1_2413589_2414159_-,NA|50aa|down_9|NZ_CP019870.1_2415073_2415223_-	NA|383aa|up_9|NZ_CP019870.1_2391095_2392244_-	COG2006, COG2006, Uncharacterized conserved protein [Function unknown]	NA|182aa|up_8|NZ_CP019870.1_2392343_2392889_-	cd01046, Rubrerythrin_like, rubrerythrin-like, diiron-binding domain	NA|315aa|up_7|NZ_CP019870.1_2393111_2394056_-	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]	NA|294aa|up_6|NZ_CP019870.1_2394441_2395323_+	cd10944, CE4_SmPgdA_like, Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins	NA|403aa|up_5|NZ_CP019870.1_2395383_2396592_-	PRK13354, PRK13354, tyrosyl-tRNA synthetase; Provisional	NA|330aa|up_4|NZ_CP019870.1_2397068_2398058_-	NA	NA|147aa|up_3|NZ_CP019870.1_2398209_2398650_+	COG2153, ElaA, Predicted acyltransferase [General function prediction only]	NA|76aa|up_2|NZ_CP019870.1_2398976_2399204_+	pfam04023, FeoA, FeoA domain	NA|707aa|up_1|NZ_CP019870.1_2399229_2401350_+	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism]	NA|273aa|up_0|NZ_CP019870.1_2401482_2402301_-	cd04782, HTH_BltR, Helix-Turn-Helix DNA binding domain of the BltR transcription regulator	NA|698aa|down_0|NZ_CP019870.1_2404707_2406801_-	cd01948, EAL, EAL domain	NA|308aa|down_1|NZ_CP019870.1_2407454_2408378_+	pfam10728, DUF2520, Domain of unknown function (DUF2520)	NA|276aa|down_2|NZ_CP019870.1_2408352_2409180_+	PRK00311, panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase; Reviewed	NA|283aa|down_3|NZ_CP019870.1_2409198_2410047_+	PRK00380, panC, pantoate--beta-alanine ligase; Reviewed	NA|61aa|down_4|NZ_CP019870.1_2410457_2410640_+	NA	NA|305aa|down_5|NZ_CP019870.1_2411471_2412386_+	pfam11155, DUF2935, Domain of unknown function (DUF2935)	NA|216aa|down_6|NZ_CP019870.1_2412775_2413423_+	pfam02589, LUD_dom, LUD domain	NA|190aa|down_7|NZ_CP019870.1_2413589_2414159_-	NA	NA|300aa|down_8|NZ_CP019870.1_2414163_2415063_-	TIGR02163, Ferredoxin-type_protein_NapH_homolog, ferredoxin-type protein, NapH/MauN family	NA|50aa|down_9|NZ_CP019870.1_2415073_2415223_-	NA
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	14	2514308-2514668	13,8,7	CRISPRCasFinder,CRT,PILER-CR	no	DinG	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Type IV-A	ATTTACATACCACTTAGTTAATATAAAAC,ATACCACTTAGTTAATATAAAAC,GTTTTATATTAACTAAGTGGTATGTAAAT	29,23,29	0	0	NA	NA	I-A:NA:I-A	5,5,4	5	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|59aa|up_5|NZ_CP019870.1_2506580_2506757_+,NA|80aa|up_4|NZ_CP019870.1_2506944_2507184_-,NA|35aa|down_0|NZ_CP019870.1_2515197_2515302_-,NA|82aa|down_1|NZ_CP019870.1_2515926_2516172_+,NA|49aa|down_2|NZ_CP019870.1_2516924_2517071_-	NA|262aa|up_9|NZ_CP019870.1_2502934_2503720_-	COG3393, COG3393, Predicted acetyltransferase [General function prediction only]	NA|122aa|up_8|NZ_CP019870.1_2504184_2504550_+	COG1733, COG1733, Predicted transcriptional regulators [Transcription]	NA|185aa|up_7|NZ_CP019870.1_2504627_2505182_+	cd01014, nicotinamidase_related, Nicotinamidase_ related amidohydrolases	NA|225aa|up_6|NZ_CP019870.1_2505401_2506076_+	COG1285, SapB, Uncharacterized membrane protein [Function unknown]	NA|59aa|up_5|NZ_CP019870.1_2506580_2506757_+	NA	NA|80aa|up_4|NZ_CP019870.1_2506944_2507184_-	NA	NA|270aa|up_3|NZ_CP019870.1_2507317_2508127_-	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators	NA|745aa|up_2|NZ_CP019870.1_2508910_2511145_+	cd01948, EAL, EAL domain	NA|278aa|up_1|NZ_CP019870.1_2511175_2512009_+	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain	NA|578aa|up_0|NZ_CP019870.1_2512248_2513982_+	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain	NA|35aa|down_0|NZ_CP019870.1_2515197_2515302_-	NA	NA|82aa|down_1|NZ_CP019870.1_2515926_2516172_+	NA	NA|49aa|down_2|NZ_CP019870.1_2516924_2517071_-	NA	NA|452aa|down_3|NZ_CP019870.1_2518356_2519712_+	cd13143, MATE_MepA_like, Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA	NA|223aa|down_4|NZ_CP019870.1_2519829_2520498_-	cd01994, Alpha_ANH_like_IV, This is a subfamily of Adenine nucleotide alpha hydrolases superfamily	NA|143aa|down_5|NZ_CP019870.1_2520564_2520993_-	pfam04657, DMT_YdcZ, Putative inner membrane exporter, YdcZ	NA|198aa|down_6|NZ_CP019870.1_2521099_2521693_+	COG3247, HdeD, Uncharacterized conserved protein [Function unknown]	NA|312aa|down_7|NZ_CP019870.1_2521811_2522747_+	COG1242, COG1242, Predicted Fe-S oxidoreductase [General function prediction only]	NA|315aa|down_8|NZ_CP019870.1_2523018_2523963_-	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter	NA|477aa|down_9|NZ_CP019870.1_2524280_2525711_+	COG3829, RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	15	2722783-2723141	14,9,8	CRISPRCasFinder,CRT,PILER-CR	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	CTTTACATACCACTTAGTTAATATAAAAC,CTTTACATACCACTTAGTTAATATAAAAC,GTTTTATATTAACTAAGTGGTATGTAAAG	29,29,29	0	0	NA	NA	I-A:I-A:I-A	5,5,4	5	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|58aa|up_7|NZ_CP019870.1_2716808_2716982_-,NA|106aa|up_6|NZ_CP019870.1_2717144_2717462_+,NA|72aa|up_5|NZ_CP019870.1_2718446_2718662_-,NA|115aa|up_4|NZ_CP019870.1_2718844_2719189_-,NA|128aa|up_3|NZ_CP019870.1_2719315_2719699_+,NA|84aa|up_2|NZ_CP019870.1_2720908_2721160_-,NA|52aa|up_1|NZ_CP019870.1_2721405_2721561_-,NA	NA|170aa|up_9|NZ_CP019870.1_2714867_2715377_-	pfam04892, VanZ, VanZ like family	NA|130aa|up_8|NZ_CP019870.1_2715696_2716086_-	pfam03965, Penicillinase_R, Penicillinase repressor	NA|58aa|up_7|NZ_CP019870.1_2716808_2716982_-	NA	NA|106aa|up_6|NZ_CP019870.1_2717144_2717462_+	NA	NA|72aa|up_5|NZ_CP019870.1_2718446_2718662_-	NA	NA|115aa|up_4|NZ_CP019870.1_2718844_2719189_-	NA	NA|128aa|up_3|NZ_CP019870.1_2719315_2719699_+	NA	NA|84aa|up_2|NZ_CP019870.1_2720908_2721160_-	NA	NA|52aa|up_1|NZ_CP019870.1_2721405_2721561_-	NA	NA|75aa|up_0|NZ_CP019870.1_2722271_2722496_+	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins	NA|476aa|down_0|NZ_CP019870.1_2724096_2725524_-	NF033435, S-layer_Clost, S-layer protein SlpA	NA|274aa|down_1|NZ_CP019870.1_2725714_2726536_+	sd00006, TPR, Tetratricopeptide repeat	NA|506aa|down_2|NZ_CP019870.1_2726660_2728178_+	cd00338, Ser_Recombinase, Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain	NA|95aa|down_3|NZ_CP019870.1_2728200_2728485_+	PRK05803, PRK05803, RNA polymerase sporulation sigma factor SigK	NA|555aa|down_4|NZ_CP019870.1_2728581_2730246_-	COG0768, FtsI, Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]	NA|416aa|down_5|NZ_CP019870.1_2730317_2731565_-	COG0826, COG0826, Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]	NA|225aa|down_6|NZ_CP019870.1_2731551_2732226_-	COG4122, COG4122, Predicted O-methyltransferase [General function prediction only]	NA|360aa|down_7|NZ_CP019870.1_2732397_2733477_-	pfam02618, YceG, YceG-like family	NA|442aa|down_8|NZ_CP019870.1_2733689_2735015_-	TIGR02644, Thymidine_phosphorylase, pyrimidine-nucleoside phosphorylase	NA|271aa|down_9|NZ_CP019870.1_2735218_2736031_-	cd09009, PNP-EcPNPII_like, purine nucleoside phosphorylases similar to human PNP and Escherichia coli PNP-II (XapA)
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	16	3296381-3296488	15	CRISPRCasFinder	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	TTTTTCTTCACTCTGCTTATATTATGAT	28	0	0	NA	NA	NA	1	1	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|61aa|up_7|NZ_CP019870.1_3282746_3282929_-,NA|54aa|up_6|NZ_CP019870.1_3283017_3283179_-,NA|397aa|down_4|NZ_CP019870.1_3302190_3303381_-	NA|233aa|up_9|NZ_CP019870.1_3273364_3274063_+	pfam12569, NARP1, NMDA receptor-regulated protein 1	NA|2711aa|up_8|NZ_CP019870.1_3274397_3282530_-	pfam12920, TcdA_TcdB_pore, TcdA/TcdB pore forming domain	NA|61aa|up_7|NZ_CP019870.1_3282746_3282929_-	NA	NA|54aa|up_6|NZ_CP019870.1_3283017_3283179_-	NA	NA|167aa|up_5|NZ_CP019870.1_3283257_3283758_-	TIGR01593, Uncharacterized_protein_CPE0383, toxin secretion/phage lysis holin	NA|2367aa|up_4|NZ_CP019870.1_3283879_3290980_-	pfam12920, TcdA_TcdB_pore, TcdA/TcdB pore forming domain	NA|185aa|up_3|NZ_CP019870.1_3291297_3291852_-	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family	NA|127aa|up_2|NZ_CP019870.1_3292758_3293139_-	pfam03965, Penicillinase_R, Penicillinase repressor	NA|398aa|up_1|NZ_CP019870.1_3293339_3294533_-	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]	NA|419aa|up_0|NZ_CP019870.1_3294595_3295852_-	cd03682, ClC_sycA_like, ClC sycA-like chloride channel proteins	NA|245aa|down_0|NZ_CP019870.1_3297427_3298162_-	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain	NA|213aa|down_1|NZ_CP019870.1_3299167_3299806_-	pfam13346, ABC2_membrane_5, ABC-2 family transporter protein	NA|286aa|down_2|NZ_CP019870.1_3299808_3300666_-	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms]	NA|125aa|down_3|NZ_CP019870.1_3300667_3301042_-	COG1725, COG1725, Predicted transcriptional regulators [Transcription]	NA|397aa|down_4|NZ_CP019870.1_3302190_3303381_-	NA	NA|652aa|down_5|NZ_CP019870.1_3303396_3305352_-	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]	NA|689aa|down_6|NZ_CP019870.1_3305368_3307435_-	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]	NA|217aa|down_7|NZ_CP019870.1_3307772_3308423_-	COG1802, GntR, Transcriptional regulators [Transcription]	NA|227aa|down_8|NZ_CP019870.1_3309839_3310520_-	pfam12679, ABC2_membrane_2, ABC-2 family transporter protein	NA|309aa|down_9|NZ_CP019870.1_3310516_3311443_-	cd03268, ABC_BcrA_bacitracin_resist, ATP-binding cassette domain of the bacitracin-resistance transporter
GCF_002007885.1_ASM200788v1	NZ_CP019870	Clostridioides difficile strain BR81 chromosome, complete genome	17	4045262-4045346	16	CRISPRCasFinder	no		cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	Orphan	ATTCCGTTGCTTAAAGTGCTAAC	23	1	10	4045285-4045323|4045285-4045323|4045285-4045323|4045285-4045323|4045285-4045323|4045285-4045323|4045285-4045323|4045285-4045323|4045285-4045323|4045285-4045323	NZ_CP019870.1_223173-223135|NZ_CP019870.1_1009507-1009469|NZ_CP019870.1_2916369-2916407|NZ_CP019870.1_3909016-3909054|NZ_CP019870.1_3925039-3925077|NZ_CP019870.1_3931989-3932027|NZ_CP019870.1_4031054-4031092|NZ_CP019870.1_4050696-4050734|NZ_CP019870.1_84454-84416|NZ_CP019870.1_3914428-3914466	NA	1	1	Orphan	cas3,WYL,csa3,cas6,cas8b2,cas7,cas5,cas4,cas1,cas2,cas14j,DEDDh,RT,cas14k,DinG	NA|138aa|up_9|NZ_CP019870.1_4023406_4023820_-,NA|74aa|up_7|NZ_CP019870.1_4034452_4034674_-,NA|87aa|down_3|NZ_CP019870.1_4054010_4054271_-	NA|138aa|up_9|NZ_CP019870.1_4023406_4023820_-	NA	NA|402aa|up_8|NZ_CP019870.1_4033176_4034382_+	cd17507, GT28_Beta-DGS-like, beta-diglucosyldiacylglycerol synthase and similar proteins	NA|74aa|up_7|NZ_CP019870.1_4034452_4034674_-	NA	NA|200aa|up_6|NZ_CP019870.1_4034814_4035414_-	PRK00076, recR, recombination protein RecR; Reviewed	NA|117aa|up_5|NZ_CP019870.1_4035426_4035777_-	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein	NA|546aa|up_4|NZ_CP019870.1_4035835_4037473_-	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated	NA|152aa|up_3|NZ_CP019870.1_4037943_4038399_-	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]	NA|424aa|up_2|NZ_CP019870.1_4038719_4039991_-	PRK05431, PRK05431, seryl-tRNA synthetase; Provisional	NA|294aa|up_1|NZ_CP019870.1_4040449_4041331_-	PRK10334, PRK10334, small-conductance mechanosensitive channel MscS	NA|170aa|up_0|NZ_CP019870.1_4041342_4041852_-	COG1827, COG1827, Predicted small molecule binding protein (contains 3H domain) [General function prediction only]	NA|258aa|down_0|NZ_CP019870.1_4052497_4053271_-	TIGR02980, SigBFG, RNA polymerase sigma-70 factor, sigma-B/F/G subfamily	NA|129aa|down_1|NZ_CP019870.1_4053270_4053657_-	PRK04069, PRK04069, serine-protein kinase RsbW; Provisional	NA|106aa|down_2|NZ_CP019870.1_4053681_4053999_-	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation	NA|87aa|down_3|NZ_CP019870.1_4054010_4054271_-	NA	NA|99aa|down_4|NZ_CP019870.1_4054270_4054567_-	pfam12732, YtxH, YtxH-like protein	NA|809aa|down_5|NZ_CP019870.1_4054635_4057062_-	PRK05560, PRK05560, DNA gyrase subunit A; Validated	NA|634aa|down_6|NZ_CP019870.1_4057081_4058983_-	PRK05644, gyrB, DNA gyrase subunit B; Validated	NA|372aa|down_7|NZ_CP019870.1_4058983_4060099_-	PRK00064, recF, recombination protein F; Reviewed	NA|69aa|down_8|NZ_CP019870.1_4060116_4060323_-	pfam13275, S4_2, S4 domain	NA|369aa|down_9|NZ_CP019870.1_4060459_4061566_-	PRK05643, PRK05643, DNA polymerase III subunit beta; Validated
