assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	1	333667-334386	1	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	CCGCCGGCGCCGCCGGNG	18	0	0	NA	NA	NA	14	14	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|61aa|up_0|NZ_CP023579.1_333106_333289_-,NA	NA|398aa|up_9|NZ_CP023579.1_323284_324478_-	COG3285, COG3285, Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]	NA|561aa|up_8|NZ_CP023579.1_324513_326196_+	PRK07788, PRK07788, acyl-CoA synthetase; Validated	NA|732aa|up_7|NZ_CP023579.1_326212_328408_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|378aa|up_6|NZ_CP023579.1_328521_329655_-	pfam12146, Hydrolase_4, Serine aminopeptidase, S33	NA|207aa|up_5|NZ_CP023579.1_329651_330272_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|194aa|up_4|NZ_CP023579.1_330368_330950_+	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	NA|242aa|up_3|NZ_CP023579.1_330879_331605_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|307aa|up_2|NZ_CP023579.1_331694_332615_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	NA|143aa|up_1|NZ_CP023579.1_332654_333083_-	cd18678, PIN_MtVapC25_VapC33-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC25, VapC33, and related proteins	NA|61aa|up_0|NZ_CP023579.1_333106_333289_-	NA	NA|838aa|down_0|NZ_CP023579.1_336490_339004_-	pfam00934, PE, PE family	NA|537aa|down_1|NZ_CP023579.1_339294_340905_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|303aa|down_2|NZ_CP023579.1_340928_341837_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|632aa|down_3|NZ_CP023579.1_342060_343956_+	TIGR03922, T7SS_EccA, type VII secretion AAA-ATPase EccA	NA|539aa|down_4|NZ_CP023579.1_343952_345569_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|1331aa|down_5|NZ_CP023579.1_345565_349558_+	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa	NA|103aa|down_6|NZ_CP023579.1_349554_349863_+	pfam00934, PE, PE family	NA|514aa|down_7|NZ_CP023579.1_349865_351407_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|98aa|down_8|NZ_CP023579.1_351455_351749_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|97aa|down_9|NZ_CP023579.1_351778_352069_+	COG4842, COG4842, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	2	366394-367092	1	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	TTCGCGAAGCCGATGTTGTAGCTGCCGGTGTTG	33	2	2	366682-366723|366757-366789	NZ_CP023579.1_374713-374754|NZ_CP023579.1_373528-373560	NA	10	10	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|101aa|up_4|NZ_CP023579.1_363406_363709_+,NA|161aa|down_1|NZ_CP023579.1_376502_376985_-,NA|410aa|down_5|NZ_CP023579.1_379101_380331_+	NA|262aa|up_9|NZ_CP023579.1_358101_358887_+	PRK14103, PRK14103, trans-aconitate 2-methyltransferase; Provisional	NA|268aa|up_8|NZ_CP023579.1_358875_359679_-	COG4424, COG4424, Uncharacterized protein conserved in bacteria [Function unknown]	NA|466aa|up_7|NZ_CP023579.1_359688_361086_-	cd16027, SGSH, N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)	NA|592aa|up_6|NZ_CP023579.1_361264_363040_+	pfam00934, PE, PE family	NA|76aa|up_5|NZ_CP023579.1_363182_363410_+	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|101aa|up_4|NZ_CP023579.1_363406_363709_+	NA	NA|74aa|up_3|NZ_CP023579.1_363756_363978_+	PHA01748, PHA01748, hypothetical protein	NA|142aa|up_2|NZ_CP023579.1_363974_364400_+	cd18755, PIN_MtVapC3_VapC21-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins	NA|211aa|up_1|NZ_CP023579.1_364535_365168_+	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|303aa|up_0|NZ_CP023579.1_365164_366073_+	cd09810, LPOR_like_SDR_c_like, light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs	NA|224aa|down_0|NZ_CP023579.1_375843_376515_+	TIGR02476, BluB, 5,6-dimethylbenzimidazole synthase	NA|161aa|down_1|NZ_CP023579.1_376502_376985_-	NA	NA|239aa|down_2|NZ_CP023579.1_377042_377759_+	cd03392, PAP2_like_2, PAP2_like_2 proteins	NA|219aa|down_3|NZ_CP023579.1_377860_378517_+	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown]	NA|164aa|down_4|NZ_CP023579.1_378586_379078_-	pfam13577, SnoaL_4, SnoaL-like domain	NA|410aa|down_5|NZ_CP023579.1_379101_380331_+	NA	NA|621aa|down_6|NZ_CP023579.1_380485_382348_+	COG0443, DnaK, Molecular chaperone [Posttranslational modification, protein turnover, chaperones]	NA|129aa|down_7|NZ_CP023579.1_382419_382806_+	COG0326, HtpG, Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]	NA|221aa|down_8|NZ_CP023579.1_382808_383471_-	pfam11259, DUF3060, Protein of unknown function (DUF3060)	NA|295aa|down_9|NZ_CP023579.1_383531_384416_+	COG2273, SKN1, Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	3	691829-691905	2	CRISPRCasFinder	no	c2c9_V-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Type V-U4	TGAGGTGCGGCGTGAGCGCGGGT	23	0	0	NA	NA	NA	1	1	TypeV-U4	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA,NA	NA|136aa|up_9|NZ_CP023579.1_677724_678132_+	cd18696, PIN_MtVapC26-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC26 and related proteins	NA|229aa|up_8|NZ_CP023579.1_678191_678878_-	pfam10738, Lpp-LpqN, Probable lipoprotein LpqN	NA|878aa|up_7|NZ_CP023579.1_679031_681665_+	COG3537, COG3537, Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]	NA|796aa|up_6|NZ_CP023579.1_681687_684075_-	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region	NA|241aa|up_5|NZ_CP023579.1_684212_684935_+	COG2186, FadR, Transcriptional regulators [Transcription]	NA|266aa|up_4|NZ_CP023579.1_684931_685729_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|296aa|up_3|NZ_CP023579.1_685730_686618_+	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|405aa|up_2|NZ_CP023579.1_686623_687838_+	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative	NA|482aa|up_1|NZ_CP023579.1_688861_690307_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|479aa|up_0|NZ_CP023579.1_690303_691740_+	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein	NA|517aa|down_0|NZ_CP023579.1_693040_694591_+	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]	NA|131aa|down_1|NZ_CP023579.1_694642_695035_-	cd18768, PIN_MtVapC4-C5-like, VapC-like PIN domain of Mycobacterium tuberculosis VapC4, VapC5, and related proteins	NA|86aa|down_2|NZ_CP023579.1_695031_695289_-	COG4118, Phd, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]	NA|412aa|down_3|NZ_CP023579.1_695471_696707_-	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only]	NA|138aa|down_4|NZ_CP023579.1_696957_697371_-	cd18681, PIN_MtVapC27-VapC40_like, VapC-like PIN domain of Mycobacterium tuberculosis VapC27, and VapC40, and related proteins	NA|79aa|down_5|NZ_CP023579.1_697367_697604_-	COG2002, AbrB, Regulators of stationary/sporulation gene expression [Transcription]	NA|169aa|down_6|NZ_CP023579.1_697707_698214_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|157aa|down_7|NZ_CP023579.1_698327_698798_-	PRK10755, PRK10755, two-component system sensor histidine kinase PmrB	NA|254aa|down_8|NZ_CP023579.1_698841_699603_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|104aa|down_9|NZ_CP023579.1_699659_699971_+	pfam03413, PepSY, Peptidase propeptide and YPEB domain
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	4	926425-927363	2	CRT	no	csa3	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Type I-A	CGGNGCCGGCGGNNCCGGCGG	21	1	3	927208-927243|927208-927243|927208-927243	NZ_CP023579.1_674931-674896|NZ_CP023579.1_1213548-1213583|NZ_CP023579.1_2423509-2423474	NA	19	19	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA,NA|184aa|down_2|NZ_CP023579.1_931373_931925_-,NA|81aa|down_8|NZ_CP023579.1_937388_937631_+	NA|685aa|up_9|NZ_CP023579.1_914061_916116_-	TIGR00350, Transcriptional_regulator_LytR, cell envelope-related function transcriptional attenuator common domain	NA|390aa|up_8|NZ_CP023579.1_916281_917451_-	TIGR00737, Probable_tRNA-dihydrouridine_synthase, putative TIM-barrel protein, nifR3 family	NA|339aa|up_7|NZ_CP023579.1_917538_918555_-	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain	NA|214aa|up_6|NZ_CP023579.1_918716_919358_-	COG1309, AcrR, Transcriptional regulator [Transcription]	NA|352aa|up_5|NZ_CP023579.1_919438_920494_+	COG3662, COG3662, Uncharacterized protein conserved in bacteria [Function unknown]	csa3|131aa|up_4|NZ_CP023579.1_920545_920938_-	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor	NA|141aa|up_3|NZ_CP023579.1_920995_921418_-	COG0590, CumB, Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]	NA|97aa|up_2|NZ_CP023579.1_921379_921670_+	COG0675, COG0675, Transposase and inactivated derivatives [DNA replication, recombination, and repair]	NA|302aa|up_1|NZ_CP023579.1_921774_922680_+	COG3315, COG3315, O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]	NA|272aa|up_0|NZ_CP023579.1_922698_923514_-	TIGR04255, hypothetical_protein, TIGR04255 family protein	NA|883aa|down_0|NZ_CP023579.1_927632_930281_-	pfam00934, PE, PE family	NA|215aa|down_1|NZ_CP023579.1_930748_931393_+	pfam14032, PknH_C, PknH-like extracellular domain	NA|184aa|down_2|NZ_CP023579.1_931373_931925_-	NA	NA|218aa|down_3|NZ_CP023579.1_932074_932728_-	COG4849, COG4849, Predicted nucleotidyltransferase [General function prediction    only]	NA|343aa|down_4|NZ_CP023579.1_932798_933827_-	COG4861, COG4861, Uncharacterized protein conserved in bacteria [Function unknown]	NA|257aa|down_5|NZ_CP023579.1_934515_935286_+	pfam01427, Peptidase_M15, D-ala-D-ala dipeptidase	NA|271aa|down_6|NZ_CP023579.1_935372_936185_+	pfam13847, Methyltransf_31, Methyltransferase domain	NA|287aa|down_7|NZ_CP023579.1_936252_937113_-	TIGR01250, Proline_iminopeptidase, proline-specific peptidase, Bacillus coagulans-type subfamily	NA|81aa|down_8|NZ_CP023579.1_937388_937631_+	NA	NA|431aa|down_9|NZ_CP023579.1_937907_939200_+	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	5	1191115-1191223	3	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GACAGCCAGCCGGCTGACCCGCCGT	25	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA,NA	NA|544aa|up_9|NZ_CP023579.1_1180482_1182114_+	cd12119, ttLC_FACS_AlkK_like, Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles	NA|355aa|up_8|NZ_CP023579.1_1182189_1183254_+	COG3804, COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]	NA|158aa|up_7|NZ_CP023579.1_1183306_1183780_+	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|up_6|NZ_CP023579.1_1183813_1184677_+	cd01908, YafJ, Glutamine amidotransferases class-II (Gn-AT)_YafJ-type	NA|286aa|up_5|NZ_CP023579.1_1184681_1185539_+	COG1752, RssA, Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]	NA|361aa|up_4|NZ_CP023579.1_1185539_1186622_-	cd07228, Pat_NTE_like_bacteria, Bacterial patatin-like phospholipase domain containing protein 6	NA|140aa|up_3|NZ_CP023579.1_1186702_1187122_-	pfam17301, LpqV, Putative lipoprotein LpqV	NA|189aa|up_2|NZ_CP023579.1_1187233_1187800_+	cd10548, cupin_CDO, cysteine dioxygenase, cupin domain	NA|132aa|up_1|NZ_CP023579.1_1187796_1188192_+	cd01447, Polysulfide_ST, Polysulfide-sulfurtransferase - Rhodanese Homology Domain	NA|668aa|up_0|NZ_CP023579.1_1188219_1190223_-	pfam00934, PE, PE family	NA|588aa|down_0|NZ_CP023579.1_1192308_1194072_-	COG4425, COG4425, Predicted membrane protein [Function unknown]	NA|258aa|down_1|NZ_CP023579.1_1194068_1194842_-	PRK05862, PRK05862, enoyl-CoA hydratase; Provisional	NA|346aa|down_2|NZ_CP023579.1_1194853_1195891_-	PRK05617, PRK05617, 3-hydroxyisobutyryl-CoA hydrolase; Provisional	NA|279aa|down_3|NZ_CP023579.1_1196077_1196914_+	COG4760, COG4760, Predicted membrane protein [Function unknown]	NA|284aa|down_4|NZ_CP023579.1_1197029_1197881_+	pfam18741, MTES_1575, REase_MTES_1575	NA|406aa|down_5|NZ_CP023579.1_1197954_1199172_-	PRK07851, PRK07851, acetyl-CoA C-acetyltransferase	NA|315aa|down_6|NZ_CP023579.1_1199224_1200169_-	cd01836, FeeA_FeeB_like, SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases	NA|356aa|down_7|NZ_CP023579.1_1200391_1201459_+	COG0657, Aes, Esterase/lipase [Lipid metabolism]	NA|465aa|down_8|NZ_CP023579.1_1201515_1202910_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|down_9|NZ_CP023579.1_1203111_1203834_+	pfam06271, RDD, RDD family
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	6	1211749-1212605	4	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GGCGGTGTCGGCGGTGCCGGCGG	23	4	73	1212132-1212153|1212177-1212192|1212315-1212336|1212315-1212336|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450|1212432-1212450	NZ_CP023579.1_2960275-2960254|NZ_CP023579.1_2088403-2088388|NZ_CP023579.1_837237-837258|NZ_CP023579.1_1217443-1217464|NZ_CP023579.1_674595-674577|NZ_CP023579.1_1213275-1213293|NZ_CP023579.1_1217416-1217434|NZ_CP023579.1_1217488-1217506|NZ_CP023579.1_1630493-1630475|NZ_CP023579.1_1633319-1633301|NZ_CP023579.1_1990606-1990588|NZ_CP023579.1_2061331-2061313|NZ_CP023579.1_2061778-2061760|NZ_CP023579.1_2061877-2061859|NZ_CP023579.1_2801824-2801806|NZ_CP023579.1_2805352-2805334|NZ_CP023579.1_150188-150206|NZ_CP023579.1_335145-335127|NZ_CP023579.1_335598-335580|NZ_CP023579.1_335649-335631|NZ_CP023579.1_335658-335640|NZ_CP023579.1_337934-337916|NZ_CP023579.1_338063-338045|NZ_CP023579.1_338330-338312|NZ_CP023579.1_338359-338377|NZ_CP023579.1_338453-338435|NZ_CP023579.1_362984-362966|NZ_CP023579.1_443265-443247|NZ_CP023579.1_546596-546578|NZ_CP023579.1_623786-623804|NZ_CP023579.1_624008-624026|NZ_CP023579.1_673761-673743|NZ_CP023579.1_840020-840038|NZ_CP023579.1_1090782-1090800|NZ_CP023579.1_1091430-1091448|NZ_CP023579.1_1095488-1095470|NZ_CP023579.1_1212804-1212822|NZ_CP023579.1_1213194-1213212|NZ_CP023579.1_1217836-1217854|NZ_CP023579.1_1489013-1488995|NZ_CP023579.1_1618457-1618439|NZ_CP023579.1_1618910-1618892|NZ_CP023579.1_1635832-1635814|NZ_CP023579.1_1635841-1635823|NZ_CP023579.1_1864120-1864102|NZ_CP023579.1_1864648-1864630|NZ_CP023579.1_1989880-1989862|NZ_CP023579.1_2001243-2001261|NZ_CP023579.1_2088601-2088583|NZ_CP023579.1_2303292-2303274|NZ_CP023579.1_2356744-2356726|NZ_CP023579.1_2419335-2419353|NZ_CP023579.1_2423422-2423404|NZ_CP023579.1_2568916-2568898|NZ_CP023579.1_2693215-2693233|NZ_CP023579.1_2795139-2795121|NZ_CP023579.1_2795721-2795703|NZ_CP023579.1_3054311-3054329|NZ_CP023579.1_3054410-3054428|NZ_CP023579.1_3705216-3705234|NZ_CP023579.1_3737193-3737175|NZ_CP023579.1_3737817-3737799|NZ_CP023579.1_3738060-3738042|NZ_CP023579.1_3738193-3738175|NZ_CP023579.1_3802056-3802074|NZ_CP023579.1_3802239-3802257|NZ_CP023579.1_3802407-3802425|NZ_CP023579.1_3930218-3930236|NZ_CP023579.1_3931948-3931966|NZ_CP023579.1_3940455-3940473|NZ_CP023579.1_3948450-3948468|NZ_CP023579.1_4031430-4031412|NZ_CP023579.1_4093952-4093970	NA	16	16	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|89aa|up_3|NZ_CP023579.1_1207181_1207448_+,NA|61aa|down_3|NZ_CP023579.1_1215023_1215206_+,NA|35aa|down_4|NZ_CP023579.1_1215315_1215420_+	NA|465aa|up_9|NZ_CP023579.1_1201515_1202910_+	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase	NA|241aa|up_8|NZ_CP023579.1_1203111_1203834_+	pfam06271, RDD, RDD family	NA|389aa|up_7|NZ_CP023579.1_1203865_1205032_+	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional	NA|165aa|up_6|NZ_CP023579.1_1205102_1205597_-	PRK00226, greA, transcription elongation factor GreA; Reviewed	NA|145aa|up_5|NZ_CP023579.1_1205782_1206217_-	pfam14155, DUF4307, Domain of unknown function (DUF4307)	NA|289aa|up_4|NZ_CP023579.1_1206318_1207185_+	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca	NA|89aa|up_3|NZ_CP023579.1_1207181_1207448_+	NA	NA|674aa|up_2|NZ_CP023579.1_1207434_1209456_+	COG1331, COG1331, Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]	NA|243aa|up_1|NZ_CP023579.1_1209554_1210283_-	TIGR01065, Hypothetical_UPF0073_protein_yqfA	NA|263aa|up_0|NZ_CP023579.1_1210393_1211182_+	PRK14828, PRK14828, undecaprenyl pyrophosphate synthase; Provisional	NA|107aa|down_0|NZ_CP023579.1_1213838_1214159_+	COG0020, UppS, Undecaprenyl pyrophosphate synthase [Lipid metabolism]	NA|145aa|down_1|NZ_CP023579.1_1214311_1214746_+	pfam00934, PE, PE family	NA|56aa|down_2|NZ_CP023579.1_1214844_1215012_+	smart00637, CBD_II, CBD_II domain	NA|61aa|down_3|NZ_CP023579.1_1215023_1215206_+	NA	NA|35aa|down_4|NZ_CP023579.1_1215315_1215420_+	NA	NA|152aa|down_5|NZ_CP023579.1_1215397_1215853_+	pfam01670, Glyco_hydro_12, Glycosyl hydrolase family 12	NA|854aa|down_6|NZ_CP023579.1_1216267_1218829_+	pfam00934, PE, PE family	NA|313aa|down_7|NZ_CP023579.1_1219046_1219985_-	PRK05439, PRK05439, pantothenate kinase; Provisional	NA|427aa|down_8|NZ_CP023579.1_1220372_1221653_+	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed	NA|276aa|down_9|NZ_CP023579.1_1221756_1222584_+	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	7	1571980-1573052	5	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	CCGCCGTTGCCGCCGGCACCGCCGTCGCCGAT	32	0	0	NA	NA	NA	15	15	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|106aa|up_7|NZ_CP023579.1_1563743_1564061_+,NA	NA|103aa|up_9|NZ_CP023579.1_1561258_1561567_+	pfam00934, PE, PE family	NA|540aa|up_8|NZ_CP023579.1_1561563_1563183_+	COG5651, COG5651, PPE-repeat proteins [Cell motility and secretion]	NA|106aa|up_7|NZ_CP023579.1_1563743_1564061_+	NA	NA|209aa|up_6|NZ_CP023579.1_1564195_1564822_+	PRK00300, gmk, guanylate kinase; Provisional	NA|111aa|up_5|NZ_CP023579.1_1564887_1565220_+	TIGR00690, DNA-directed_RNA_polymerase_subunit_omega, DNA-directed RNA polymerase, omega subunit	NA|419aa|up_4|NZ_CP023579.1_1565235_1566492_+	PRK05579, PRK05579, bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated	NA|404aa|up_3|NZ_CP023579.1_1566619_1567831_+	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated	NA|493aa|up_2|NZ_CP023579.1_1567903_1569382_-	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]	NA|462aa|up_1|NZ_CP023579.1_1569378_1570764_-	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|345aa|up_0|NZ_CP023579.1_1570841_1571876_+	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein	NA|134aa|down_0|NZ_CP023579.1_1573906_1574308_-	cd18741, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily	NA|86aa|down_1|NZ_CP023579.1_1574304_1574562_-	pfam01402, RHH_1, Ribbon-helix-helix protein, copG family	NA|320aa|down_2|NZ_CP023579.1_1574644_1575604_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|321aa|down_3|NZ_CP023579.1_1575628_1576591_-	pfam07859, Abhydrolase_3, alpha/beta hydrolase fold	NA|201aa|down_4|NZ_CP023579.1_1576724_1577327_+	COG3714, COG3714, Predicted membrane protein [Function unknown]	NA|656aa|down_5|NZ_CP023579.1_1577407_1579375_+	PRK14873, PRK14873, primosomal protein N'	NA|275aa|down_6|NZ_CP023579.1_1579392_1580217_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|161aa|down_7|NZ_CP023579.1_1580385_1580868_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein	NA|275aa|down_8|NZ_CP023579.1_1580939_1581764_-	pfam13649, Methyltransf_25, Methyltransferase domain	NA|313aa|down_9|NZ_CP023579.1_1581960_1582899_+	PRK00005, fmt, methionyl-tRNA formyltransferase; Reviewed
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	8	2088073-2088327	3	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GCCNCCGTCGCCGCCNNTGCC	21	2	3	2088154-2088171|2088154-2088171|2088244-2088261	NZ_CP023579.1_401009-400992|NZ_CP023579.1_607241-607224|NZ_CP023579.1_3449917-3449900	NA	5	5	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|88aa|up_0|NZ_CP023579.1_2087432_2087696_-,NA	NA|165aa|up_9|NZ_CP023579.1_2073726_2074221_+	pfam02577, DNase-RNase, Bifunctional nuclease	NA|226aa|up_8|NZ_CP023579.1_2074624_2075302_+	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators	NA|942aa|up_7|NZ_CP023579.1_2075660_2078486_+	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase	NA|287aa|up_6|NZ_CP023579.1_2078712_2079573_-	PRK03204, PRK03204, haloalkane dehalogenase; Provisional	NA|289aa|up_5|NZ_CP023579.1_2079613_2080480_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|629aa|up_4|NZ_CP023579.1_2080484_2082371_-	TIGR00976, Hypothetical_protein_Rv1835c/MT1883/Mb1866c	NA|678aa|up_3|NZ_CP023579.1_2082386_2084420_-	cd01456, vWA_ywmD_type, VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF)	NA|742aa|up_2|NZ_CP023579.1_2084539_2086765_-	PRK02999, PRK02999, malate synthase G; Provisional	NA|132aa|up_1|NZ_CP023579.1_2087040_2087436_-	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]	NA|88aa|up_0|NZ_CP023579.1_2087432_2087696_-	NA	NA|346aa|down_0|NZ_CP023579.1_2089455_2090493_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|456aa|down_1|NZ_CP023579.1_2090492_2091860_-	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only]	NA|479aa|down_2|NZ_CP023579.1_2092033_2093470_-	PRK07807, PRK07807, GuaB1 family IMP dehydrogenase-related protein	NA|484aa|down_3|NZ_CP023579.1_2093505_2094957_-	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase	NA|317aa|down_4|NZ_CP023579.1_2094986_2095937_-	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase	NA|139aa|down_5|NZ_CP023579.1_2095951_2096368_-	COG3682, COG3682, Predicted transcriptional regulator [Transcription]	NA|141aa|down_6|NZ_CP023579.1_2096645_2097068_+	COG2050, PaaI, HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]	NA|101aa|down_7|NZ_CP023579.1_2097116_2097419_+	pfam00547, Urease_gamma, Urease, gamma subunit	NA|105aa|down_8|NZ_CP023579.1_2097415_2097730_+	PRK13202, ureB, urease subunit beta; Reviewed	NA|578aa|down_9|NZ_CP023579.1_2097729_2099463_+	PRK13206, ureC, urease subunit alpha; Reviewed
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	9	2163156-2163260	6	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	CAACCCAAACGGATTAATCGCGAAACCAGGGATCGT	36	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|136aa|up_2|NZ_CP023579.1_2159700_2160108_-,NA|127aa|down_6|NZ_CP023579.1_2176329_2176710_-	NA|216aa|up_9|NZ_CP023579.1_2153014_2153662_-	pfam14081, DUF4262, Domain of unknown function (DUF4262)	NA|741aa|up_8|NZ_CP023579.1_2153668_2155891_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_7|NZ_CP023579.1_2155928_2156372_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_6|NZ_CP023579.1_2156485_2157079_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_5|NZ_CP023579.1_2157161_2157767_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_4|NZ_CP023579.1_2157866_2158871_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_3|NZ_CP023579.1_2158970_2159723_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_2|NZ_CP023579.1_2159700_2160108_-	NA	NA|368aa|up_1|NZ_CP023579.1_2160242_2161346_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|399aa|up_0|NZ_CP023579.1_2161345_2162542_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|988aa|down_0|NZ_CP023579.1_2167428_2170392_-	pfam00823, PPE, PPE family	NA|155aa|down_1|NZ_CP023579.1_2170840_2171305_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_2|NZ_CP023579.1_2171402_2172266_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_3|NZ_CP023579.1_2172303_2173575_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_4|NZ_CP023579.1_2173846_2174962_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_5|NZ_CP023579.1_2174952_2176293_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_6|NZ_CP023579.1_2176329_2176710_-	NA	NA|621aa|down_7|NZ_CP023579.1_2176866_2178729_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_8|NZ_CP023579.1_2178736_2179216_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_9|NZ_CP023579.1_2179452_2180226_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	10	2168594-2168813	7	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GTGCCAGCCGGAATCGTGATCGGCGGAACCGTCACCGACGGAATACTCA	49	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|136aa|up_3|NZ_CP023579.1_2159700_2160108_-,NA|127aa|down_5|NZ_CP023579.1_2176329_2176710_-	NA|741aa|up_9|NZ_CP023579.1_2153668_2155891_-	PRK15061, PRK15061, catalase/peroxidase	NA|148aa|up_8|NZ_CP023579.1_2155928_2156372_-	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]	NA|198aa|up_7|NZ_CP023579.1_2156485_2157079_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|202aa|up_6|NZ_CP023579.1_2157161_2157767_-	COG1881, COG1881, Phospholipid-binding protein [General function prediction only]	NA|335aa|up_5|NZ_CP023579.1_2157866_2158871_-	cd08275, MDR3, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family	NA|251aa|up_4|NZ_CP023579.1_2158970_2159723_+	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|136aa|up_3|NZ_CP023579.1_2159700_2160108_-	NA	NA|368aa|up_2|NZ_CP023579.1_2160242_2161346_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|399aa|up_1|NZ_CP023579.1_2161345_2162542_+	COG2224, AceA, Isocitrate lyase [Energy production and conversion]	NA|1460aa|up_0|NZ_CP023579.1_2162711_2167091_-	pfam00823, PPE, PPE family	NA|155aa|down_0|NZ_CP023579.1_2170840_2171305_-	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins	NA|288aa|down_1|NZ_CP023579.1_2171402_2172266_+	cd07987, LPLAT_MGAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like	NA|424aa|down_2|NZ_CP023579.1_2172303_2173575_-	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|372aa|down_3|NZ_CP023579.1_2173846_2174962_+	COG1680, AmpC, Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]	NA|447aa|down_4|NZ_CP023579.1_2174952_2176293_+	pfam00144, Beta-lactamase, Beta-lactamase	NA|127aa|down_5|NZ_CP023579.1_2176329_2176710_-	NA	NA|621aa|down_6|NZ_CP023579.1_2176866_2178729_+	PRK12476, PRK12476, putative fatty-acid--CoA ligase; Provisional	NA|160aa|down_7|NZ_CP023579.1_2178736_2179216_-	pfam09167, DUF1942, Domain of unknown function (DUF1942)	NA|258aa|down_8|NZ_CP023579.1_2179452_2180226_+	COG3361, COG3361, Uncharacterized conserved protein [Function unknown]	NA|256aa|down_9|NZ_CP023579.1_2180229_2180997_-	PRK05867, PRK05867, SDR family oxidoreductase
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	11	3118893-3120247	1,8,4	PILER-CR,CRISPRCasFinder,CRT	no	c2c9_V-U4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Type III-D,Type III-C,Type III-A,Type III-B	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A	17,17,18	18	TypeIII-D,TypeIII-C,TypeIII-A,TypeIII-B	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|85aa|up_8|NZ_CP023579.1_3112172_3112427_-,NA|135aa|up_7|NZ_CP023579.1_3112574_3112979_+,NA|64aa|up_6|NZ_CP023579.1_3112975_3113167_+,NA|86aa|up_4|NZ_CP023579.1_3114753_3115011_+,NA|104aa|up_3|NZ_CP023579.1_3115115_3115427_+,NA|203aa|up_2|NZ_CP023579.1_3115846_3116455_+,NA	NA|92aa|up_9|NZ_CP023579.1_3111721_3111997_+	COG4453, COG4453, Uncharacterized protein conserved in bacteria [Function unknown]	NA|85aa|up_8|NZ_CP023579.1_3112172_3112427_-	NA	NA|135aa|up_7|NZ_CP023579.1_3112574_3112979_+	NA	NA|64aa|up_6|NZ_CP023579.1_3112975_3113167_+	NA	NA|385aa|up_5|NZ_CP023579.1_3113365_3114520_+	pfam00665, rve, Integrase core domain	NA|86aa|up_4|NZ_CP023579.1_3114753_3115011_+	NA	NA|104aa|up_3|NZ_CP023579.1_3115115_3115427_+	NA	NA|203aa|up_2|NZ_CP023579.1_3115846_3116455_+	NA	NA|470aa|up_1|NZ_CP023579.1_3116525_3117935_+	pfam00665, rve, Integrase core domain	NA|271aa|up_0|NZ_CP023579.1_3117931_3118744_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|down_0|NZ_CP023579.1_3120273_3121535_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_1|NZ_CP023579.1_3123332_3123674_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_2|NZ_CP023579.1_3123674_3124691_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_3|NZ_CP023579.1_3124703_3125852_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_4|NZ_CP023579.1_3125947_3127075_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_5|NZ_CP023579.1_3127071_3127980_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_6|NZ_CP023579.1_3127960_3128671_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_7|NZ_CP023579.1_3128680_3129055_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_8|NZ_CP023579.1_3129051_3131490_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_9|NZ_CP023579.1_3131486_3132209_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	12	3121570-3123284	9,5,2,3	CRISPRCasFinder,CRT,PILER-CR,PILER-CR	no	cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Type III-D,Type III-C,Type III-A,Type III-B	GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC,GTTTCCGTCCCCTCTCGGGGTTTTGGGTCTGACGAC	36,36,36,36	0	0	NA	NA	II-B,III-A:II-B,III-A:II-B,III-A:II-B,III-A	23,23,20,20	23	TypeIII-D,TypeIII-C,TypeIII-A,TypeIII-B	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|85aa|up_9|NZ_CP023579.1_3112172_3112427_-,NA|135aa|up_8|NZ_CP023579.1_3112574_3112979_+,NA|64aa|up_7|NZ_CP023579.1_3112975_3113167_+,NA|86aa|up_5|NZ_CP023579.1_3114753_3115011_+,NA|104aa|up_4|NZ_CP023579.1_3115115_3115427_+,NA|203aa|up_3|NZ_CP023579.1_3115846_3116455_+,NA	NA|85aa|up_9|NZ_CP023579.1_3112172_3112427_-	NA	NA|135aa|up_8|NZ_CP023579.1_3112574_3112979_+	NA	NA|64aa|up_7|NZ_CP023579.1_3112975_3113167_+	NA	NA|385aa|up_6|NZ_CP023579.1_3113365_3114520_+	pfam00665, rve, Integrase core domain	NA|86aa|up_5|NZ_CP023579.1_3114753_3115011_+	NA	NA|104aa|up_4|NZ_CP023579.1_3115115_3115427_+	NA	NA|203aa|up_3|NZ_CP023579.1_3115846_3116455_+	NA	NA|470aa|up_2|NZ_CP023579.1_3116525_3117935_+	pfam00665, rve, Integrase core domain	NA|271aa|up_1|NZ_CP023579.1_3117931_3118744_+	COG3267, ExeA, Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]	NA|421aa|up_0|NZ_CP023579.1_3120273_3121535_-	PHA02517, PHA02517, putative transposase OrfB; Reviewed	cas2|114aa|down_0|NZ_CP023579.1_3123332_3123674_-	COG1343, COG1343, CRISPR-associated protein Cas2 [Defense mechanisms]	cas1|339aa|down_1|NZ_CP023579.1_3123674_3124691_-	TIGR00287, CRISPR-associated_endonuclease_Cas1, CRISPR-associated endonuclease Cas1	csm6|383aa|down_2|NZ_CP023579.1_3124703_3125852_-	cd09699, Csm6_III-A, CRISPR/Cas system-associated protein Csm6	csm5gr7|376aa|down_3|NZ_CP023579.1_3125947_3127075_-	COG1332, COG1332, CRISPR system related protein, RAMP superfamily [Defense mechanisms]	csm4gr5|303aa|down_4|NZ_CP023579.1_3127071_3127980_-	COG1567, COG1567, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	csm3gr7|237aa|down_5|NZ_CP023579.1_3127960_3128671_-	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3	csm2gr11|125aa|down_6|NZ_CP023579.1_3128680_3129055_-	TIGR01870, CRISPR_type_III-associated_protein_Csm2, CRISPR type III-A/MTUBE-associated protein Csm2	cas10|813aa|down_7|NZ_CP023579.1_3129051_3131490_-	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10	cas6|241aa|down_8|NZ_CP023579.1_3131486_3132209_-	COG5551, COG5551, CRISPR system related protein, RAMP superfamily [Defense    mechanisms]	NA|182aa|down_9|NZ_CP023579.1_3132608_3133154_-	COG4293, COG4293, Uncharacterized protein conserved in bacteria [Function unknown]
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	13	3740387-3740928	6	CRT	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	CCGCCGTTNCCNCCGTTGCCGCC	23	0	0	NA	NA	NA	7	7	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA,NA|96aa|down_4|NZ_CP023579.1_3755029_3755317_-,NA|87aa|down_9|NZ_CP023579.1_3768437_3768698_-	NA|282aa|up_9|NZ_CP023579.1_3719638_3720484_-	pfam05305, DUF732, Protein of unknown function (DUF732)	NA|147aa|up_8|NZ_CP023579.1_3720958_3721399_+	cd04770, HTH_HMRTR, Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators	NA|290aa|up_7|NZ_CP023579.1_3721432_3722302_-	TIGR00766, Uncharacterized_protein_Dda3937_02003, inner membrane protein YhjD	NA|337aa|up_6|NZ_CP023579.1_3722322_3723333_-	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed	NA|211aa|up_5|NZ_CP023579.1_3723617_3724250_+	PRK14875, PRK14875, acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional	NA|410aa|up_4|NZ_CP023579.1_3724316_3725546_-	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase	NA|450aa|up_3|NZ_CP023579.1_3725828_3727178_+	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated	NA|380aa|up_2|NZ_CP023579.1_3727189_3728329_+	PRK00175, metX, homoserine O-acetyltransferase; Provisional	NA|244aa|up_1|NZ_CP023579.1_3728325_3729057_+	pfam08241, Methyltransf_11, Methyltransferase domain	NA|2524aa|up_0|NZ_CP023579.1_3729065_3736637_-	pfam00823, PPE, PPE family	NA|86aa|down_0|NZ_CP023579.1_3742899_3743157_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|3158aa|down_1|NZ_CP023579.1_3743412_3752886_-	pfam00823, PPE, PPE family	NA|149aa|down_2|NZ_CP023579.1_3753511_3753958_+	pfam01548, DEDD_Tnp_IS110, Transposase	NA|247aa|down_3|NZ_CP023579.1_3753994_3754735_-	pfam01610, DDE_Tnp_ISL3, Transposase	NA|96aa|down_4|NZ_CP023579.1_3755029_3755317_-	NA	NA|3717aa|down_5|NZ_CP023579.1_3755653_3766804_-	pfam00823, PPE, PPE family	NA|265aa|down_6|NZ_CP023579.1_3767047_3767842_-	pfam08031, BBE, Berberine and berberine like	NA|124aa|down_7|NZ_CP023579.1_3767923_3768295_-	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion]	NA|73aa|down_8|NZ_CP023579.1_3768192_3768411_-	pfam01565, FAD_binding_4, FAD binding domain	NA|87aa|down_9|NZ_CP023579.1_3768437_3768698_-	NA
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	14	3762185-3762311	4	PILER-CR	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GTTGCCGATGCCGGTGTTGAAA	22	0	0	NA	NA	NA	2	2	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|96aa|up_0|NZ_CP023579.1_3755029_3755317_-,NA|87aa|down_3|NZ_CP023579.1_3768437_3768698_-	NA|410aa|up_9|NZ_CP023579.1_3724316_3725546_-	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase	NA|450aa|up_8|NZ_CP023579.1_3725828_3727178_+	PRK07812, PRK07812, O-acetylhomoserine aminocarboxypropyltransferase; Validated	NA|380aa|up_7|NZ_CP023579.1_3727189_3728329_+	PRK00175, metX, homoserine O-acetyltransferase; Provisional	NA|244aa|up_6|NZ_CP023579.1_3728325_3729057_+	pfam08241, Methyltransf_11, Methyltransferase domain	NA|2524aa|up_5|NZ_CP023579.1_3729065_3736637_-	pfam00823, PPE, PPE family	NA|86aa|up_4|NZ_CP023579.1_3742899_3743157_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|3158aa|up_3|NZ_CP023579.1_3743412_3752886_-	pfam00823, PPE, PPE family	NA|149aa|up_2|NZ_CP023579.1_3753511_3753958_+	pfam01548, DEDD_Tnp_IS110, Transposase	NA|247aa|up_1|NZ_CP023579.1_3753994_3754735_-	pfam01610, DDE_Tnp_ISL3, Transposase	NA|96aa|up_0|NZ_CP023579.1_3755029_3755317_-	NA	NA|265aa|down_0|NZ_CP023579.1_3767047_3767842_-	pfam08031, BBE, Berberine and berberine like	NA|124aa|down_1|NZ_CP023579.1_3767923_3768295_-	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion]	NA|73aa|down_2|NZ_CP023579.1_3768192_3768411_-	pfam01565, FAD_binding_4, FAD binding domain	NA|87aa|down_3|NZ_CP023579.1_3768437_3768698_-	NA	NA|130aa|down_4|NZ_CP023579.1_3768812_3769202_+	pfam05305, DUF732, Protein of unknown function (DUF732)	NA|98aa|down_5|NZ_CP023579.1_3769215_3769509_-	pfam11222, DUF3017, Protein of unknown function (DUF3017)	NA|282aa|down_6|NZ_CP023579.1_3769505_3770351_-	PRK14193, PRK14193, bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional	NA|92aa|down_7|NZ_CP023579.1_3770474_3770750_+	COG2161, StbD, Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]	NA|86aa|down_8|NZ_CP023579.1_3770746_3771004_+	pfam06769, YoeB_toxin, YoeB-like toxin of bacterial type II toxin-antitoxin system	NA|397aa|down_9|NZ_CP023579.1_3771045_3772236_+	cd02803, OYE_like_FMN_family, Old yellow enzyme (OYE)-like FMN binding domain
GCF_002446995.1_ASM244699v1	NZ_CP023579	Mycobacterium tuberculosis strain LE492 chromosome, complete genome	15	4110369-4110457	10	CRISPRCasFinder	no		RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	Orphan	GCTCGGCGACGATGCGGGCCGGATGACGGCC	31	0	0	NA	NA	NA	1	1	Orphan	RT,csa3,c2c9_V-U4,cas3,DinG,WYL,cas4,cas2,cas1,csm6,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas6,DEDDh	NA|257aa|up_8|NZ_CP023579.1_4100955_4101726_-,NA|119aa|up_3|NZ_CP023579.1_4106860_4107217_+,NA|52aa|up_2|NZ_CP023579.1_4107316_4107472_+,NA|233aa|up_0|NZ_CP023579.1_4109473_4110172_-,NA|126aa|down_6|NZ_CP023579.1_4115692_4116070_+	NA|288aa|up_9|NZ_CP023579.1_4099337_4100201_+	TIGR01490, Uncharacterized_protein_Rv3661/MT3761, HAD-superfamily subfamily IB hydrolase, TIGR01490	NA|257aa|up_8|NZ_CP023579.1_4100955_4101726_-	NA	NA|549aa|up_7|NZ_CP023579.1_4101722_4103369_-	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]	NA|288aa|up_6|NZ_CP023579.1_4103365_4104229_-	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|309aa|up_5|NZ_CP023579.1_4104221_4105148_-	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|542aa|up_4|NZ_CP023579.1_4105149_4106775_-	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold	NA|119aa|up_3|NZ_CP023579.1_4106860_4107217_+	NA	NA|52aa|up_2|NZ_CP023579.1_4107316_4107472_+	NA	NA|652aa|up_1|NZ_CP023579.1_4107482_4109438_+	PRK00174, PRK00174, acetyl-CoA synthetase; Provisional	NA|233aa|up_0|NZ_CP023579.1_4109473_4110172_-	NA	NA|173aa|down_0|NZ_CP023579.1_4110517_4111036_+	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III	NA|328aa|down_1|NZ_CP023579.1_4111036_4112020_+	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]	NA|398aa|down_2|NZ_CP023579.1_4112012_4113206_-	pfam13365, Trypsin_2, Trypsin-like peptidase domain	NA|274aa|down_3|NZ_CP023579.1_4113211_4114033_-	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes	NA|228aa|down_4|NZ_CP023579.1_4114164_4114848_-	cd02966, TlpA_like_family, TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins	NA|246aa|down_5|NZ_CP023579.1_4114847_4115585_-	COG0177, Nth, Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]	NA|126aa|down_6|NZ_CP023579.1_4115692_4116070_+	NA	NA|225aa|down_7|NZ_CP023579.1_4116168_4116843_+	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]	NA|265aa|down_8|NZ_CP023579.1_4116948_4117743_-	cd16278, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain	NA|152aa|down_9|NZ_CP023579.1_4117749_4118205_-	cd02199, YjgF_YER057c_UK114_like_1, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function
