assembly_id	genome_id	genome_def	crispr_array_locus_merge	crispr_array_location_merge	crispr_locus_id	crispr_pred_method	array_in_prot	prot_within_array_20000	prot_in_genome	crispr_type_by_cas_prot	consensus_repeat	repeat_length	self-targeting_spacer_number	self-targeting_target_number	spacer_location	protospacer_location	repeat_type	spacer_locus_num	spacer_num	correct_crispr_type	genome_cas_prots	unknown_protein_around_crispr	L10	L10_domain	L9	L9_domain	L8	L8_domain	L7	L7_domain	L6	L6_domain	L5	L5_domain	L4	L4_domain	L3	L3_domain	L2	L2_domain	L1	L1_domain	R1	R1_domain	R2	R2_domain	R3	R3_domain	R4	R4_domain	R5	R5_domain	R6	R6_domain	R7	R7_domain	R8	R8_domain	R9	R9_domain	R10	R10_domain
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	1	325975-326180	1,1	PILER-CR,CRISPRCasFinder	no	RT	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Unclear	GGGACCATCCCCGCGCCTGCGGGGAGC,GGACCATCCCCGCGCCTGCGGGG	27,23	0	0	NA	NA	NA:NA	2,3	3	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA,NA|243aa|down_2|NZ_CP042266.1_331047_331776_-,NA|115aa|down_4|NZ_CP042266.1_333318_333663_+,NA|217aa|down_8|NZ_CP042266.1_336017_336668_-,NA|72aa|down_9|NZ_CP042266.1_336660_336876_-	NA|296aa|up_9|NZ_CP042266.1_315215_316103_-	COG1108, ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]	NA|239aa|up_8|NZ_CP042266.1_316153_316870_+	COG1121, ZnuC, ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]	NA|397aa|up_7|NZ_CP042266.1_317187_318378_-	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26	NA|361aa|up_6|NZ_CP042266.1_318573_319656_+	PRK05617, PRK05617, 3-hydroxyisobutyryl-CoA hydrolase; Provisional	NA|347aa|up_5|NZ_CP042266.1_319803_320844_-	PRK09393, ftrA, transcriptional activator FtrA; Provisional	NA|99aa|up_4|NZ_CP042266.1_321078_321375_+	pfam03928, Haem_degrading, Haem-degrading	NA|349aa|up_3|NZ_CP042266.1_321580_322627_+	TIGR03401, Uncharacterized_protein_YFL061W/YNL335W, HD domain protein, cyanamide hydratase family	NA|284aa|up_2|NZ_CP042266.1_322751_323603_-	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain	NA|505aa|up_1|NZ_CP042266.1_323706_325221_+	PRK14995, PRK14995, SmvA family efflux MFS transporter	NA|190aa|up_0|NZ_CP042266.1_325324_325894_-	cd05155, APH_ChoK_like_1, Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase and Choline kinase	NA|848aa|down_0|NZ_CP042266.1_326323_328867_-	PRK06241, PRK06241, phosphoenolpyruvate synthase; Validated	NA|570aa|down_1|NZ_CP042266.1_329145_330855_-	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment	NA|243aa|down_2|NZ_CP042266.1_331047_331776_-	NA	NA|332aa|down_3|NZ_CP042266.1_332028_333024_+	PRK09685, PRK09685, DNA-binding transcriptional activator FeaR; Provisional	NA|115aa|down_4|NZ_CP042266.1_333318_333663_+	NA	NA|181aa|down_5|NZ_CP042266.1_333741_334284_-	COG3911, COG3911, Predicted ATPase [General function prediction only]	NA|137aa|down_6|NZ_CP042266.1_334816_335227_-	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X	NA|303aa|down_7|NZ_CP042266.1_335223_336132_-	pfam04672, Methyltransf_19, S-adenosyl methyltransferase	NA|217aa|down_8|NZ_CP042266.1_336017_336668_-	NA	NA|72aa|down_9|NZ_CP042266.1_336660_336876_-	NA
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	2	810931-811080	2,2	CRISPRCasFinder,PILER-CR	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	GGCCATCCCCTCGTCCGCGGGGAGCACAC,GGCCATCCCCTCGTCCGCGGGGAGCACAC	29,29	0	0	NA	NA	NA:NA	2,2	2	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|173aa|up_9|NZ_CP042266.1_796815_797334_+,NA|242aa|up_7|NZ_CP042266.1_800992_801718_+,NA|161aa|up_6|NZ_CP042266.1_802920_803403_-,NA|100aa|up_5|NZ_CP042266.1_805019_805319_+,NA|205aa|up_4|NZ_CP042266.1_805354_805969_-,NA|85aa|down_3|NZ_CP042266.1_817051_817306_-	NA|173aa|up_9|NZ_CP042266.1_796815_797334_+	NA	NA|534aa|up_8|NZ_CP042266.1_797873_799475_-	pfam14200, RicinB_lectin_2, Ricin-type beta-trefoil lectin domain-like	NA|242aa|up_7|NZ_CP042266.1_800992_801718_+	NA	NA|161aa|up_6|NZ_CP042266.1_802920_803403_-	NA	NA|100aa|up_5|NZ_CP042266.1_805019_805319_+	NA	NA|205aa|up_4|NZ_CP042266.1_805354_805969_-	NA	NA|141aa|up_3|NZ_CP042266.1_806011_806434_-	COG0432, COG0432, Uncharacterized conserved protein [Function unknown]	NA|364aa|up_2|NZ_CP042266.1_806507_807599_+	COG2072, TrkA, Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]	NA|280aa|up_1|NZ_CP042266.1_807618_808458_-	cd08010, MltG_like, proteins similar to Escherichia coli YceG/mltG may function as endolytic murein transglycosylases	NA|603aa|up_0|NZ_CP042266.1_808555_810364_-	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]	NA|496aa|down_0|NZ_CP042266.1_811370_812858_+	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only]	NA|611aa|down_1|NZ_CP042266.1_813040_814873_+	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]	NA|594aa|down_2|NZ_CP042266.1_814955_816737_+	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]	NA|85aa|down_3|NZ_CP042266.1_817051_817306_-	NA	NA|264aa|down_4|NZ_CP042266.1_817552_818344_-	pfam04307, YdjM, LexA-binding, inner membrane-associated putative hydrolase	NA|838aa|down_5|NZ_CP042266.1_818708_821222_+	pfam12029, DUF3516, Domain of unknown function (DUF3516)	NA|295aa|down_6|NZ_CP042266.1_821273_822158_+	COG1946, TesB, Acyl-CoA thioesterase [Lipid metabolism]	NA|164aa|down_7|NZ_CP042266.1_822198_822690_+	cd00340, GSH_Peroxidase, Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate	NA|411aa|down_8|NZ_CP042266.1_822739_823972_-	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases	NA|221aa|down_9|NZ_CP042266.1_824139_824802_+	COG1309, AcrR, Transcriptional regulator [Transcription]
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	3	2131827-2131931	3	CRISPRCasFinder	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	TGCTCTGCCAATTGAGCTACAGGGGAT	27	0	0	NA	NA	NA	1	1	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|64aa|up_4|NZ_CP042266.1_2128275_2128467_-,NA|87aa|up_1|NZ_CP042266.1_2130103_2130364_-,NA|99aa|up_0|NZ_CP042266.1_2130970_2131267_+,NA|100aa|down_0|NZ_CP042266.1_2132113_2132413_+	NA|411aa|up_9|NZ_CP042266.1_2121727_2122960_+	COG2223, NarK, Nitrate/nitrite transporter [Inorganic ion transport and metabolism]	NA|490aa|up_8|NZ_CP042266.1_2123207_2124677_+	PRK07787, PRK07787, acyl-CoA synthetase; Validated	NA|654aa|up_7|NZ_CP042266.1_2124771_2126733_-	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]	NA|272aa|up_6|NZ_CP042266.1_2126812_2127628_-	cd13538, PBP2_ModA_like_1, Substrate binding domain of putative molybdate-binding protein;the type 2 periplasmic binding protein fold	NA|132aa|up_5|NZ_CP042266.1_2127641_2128037_-	cd04762, HTH_MerR-trunc, Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins	NA|64aa|up_4|NZ_CP042266.1_2128275_2128467_-	NA	NA|312aa|up_3|NZ_CP042266.1_2128803_2129739_+	pfam01510, Amidase_2, N-acetylmuramoyl-L-alanine amidase	NA|78aa|up_2|NZ_CP042266.1_2129820_2130054_-	pfam09957, VapB_antitoxin, Bacterial antitoxin of type II TA system, VapB	NA|87aa|up_1|NZ_CP042266.1_2130103_2130364_-	NA	NA|99aa|up_0|NZ_CP042266.1_2130970_2131267_+	NA	NA|100aa|down_0|NZ_CP042266.1_2132113_2132413_+	NA	NA|508aa|down_1|NZ_CP042266.1_2132565_2134089_+	cd07809, FGGY_D-XK_1, D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases	NA|578aa|down_2|NZ_CP042266.1_2134416_2136150_+	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]	NA|647aa|down_3|NZ_CP042266.1_2136146_2138087_+	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]	NA|385aa|down_4|NZ_CP042266.1_2138242_2139397_-	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional	NA|646aa|down_5|NZ_CP042266.1_2140114_2142052_-	PRK05667, dnaG, DNA primase; Validated	NA|425aa|down_6|NZ_CP042266.1_2142129_2143404_-	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional	NA|479aa|down_7|NZ_CP042266.1_2143558_2144995_-	PRK03007, PRK03007, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional	NA|253aa|down_8|NZ_CP042266.1_2145119_2145878_+	COG2949, SanA, Uncharacterized membrane protein [Function unknown]	NA|194aa|down_9|NZ_CP042266.1_2145957_2146539_+	TIGR03086, TIGR03086, TIGR03086 family protein
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	4	2231277-2231373	4	CRISPRCasFinder	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	CCGGGCGGAGCCCCGGGCCGCCG	23	0	0	NA	NA	NA	1	1	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|78aa|up_8|NZ_CP042266.1_2220482_2220716_-,NA|389aa|up_0|NZ_CP042266.1_2229441_2230608_-,NA|187aa|down_0|NZ_CP042266.1_2231513_2232074_-,NA|174aa|down_2|NZ_CP042266.1_2233667_2234189_-	NA|519aa|up_9|NZ_CP042266.1_2218525_2220082_+	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]	NA|78aa|up_8|NZ_CP042266.1_2220482_2220716_-	NA	NA|489aa|up_7|NZ_CP042266.1_2220955_2222422_-	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily	NA|272aa|up_6|NZ_CP042266.1_2222689_2223505_+	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain	NA|219aa|up_5|NZ_CP042266.1_2223799_2224456_-	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1)	NA|144aa|up_4|NZ_CP042266.1_2224452_2224884_-	pfam02410, RsfS, Ribosomal silencing factor during starvation	NA|594aa|up_3|NZ_CP042266.1_2225028_2226810_-	pfam13399, LytR_C, LytR cell envelope-related transcriptional attenuator	NA|215aa|up_2|NZ_CP042266.1_2226829_2227474_-	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase	NA|370aa|up_1|NZ_CP042266.1_2227977_2229087_+	cd07325, M48_Ste24p_like, M48 Ste24 endopeptidase-like, integral membrane metallopeptidase	NA|389aa|up_0|NZ_CP042266.1_2229441_2230608_-	NA	NA|187aa|down_0|NZ_CP042266.1_2231513_2232074_-	NA	NA|429aa|down_1|NZ_CP042266.1_2232183_2233470_-	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional	NA|174aa|down_2|NZ_CP042266.1_2233667_2234189_-	NA	NA|369aa|down_3|NZ_CP042266.1_2234323_2235430_-	PRK05429, PRK05429, gamma-glutamyl kinase; Provisional	NA|681aa|down_4|NZ_CP042266.1_2235676_2237719_-	pfam04464, Glyphos_transf, CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase	NA|500aa|down_5|NZ_CP042266.1_2237962_2239462_-	cd02516, CDP-ME_synthetase, CDP-ME synthetase is involved in mevalonate-independent isoprenoid production	NA|754aa|down_6|NZ_CP042266.1_2239658_2241920_-	cd03820, GT4_AmsD-like, amylovoran biosynthesis glycosyltransferase AmsD and similar proteins	NA|480aa|down_7|NZ_CP042266.1_2242154_2243594_-	PRK12296, obgE, GTPase CgtA; Reviewed	NA|85aa|down_8|NZ_CP042266.1_2243814_2244069_-	PRK05435, rpmA, 50S ribosomal protein L27; Validated	NA|107aa|down_9|NZ_CP042266.1_2244083_2244404_-	PRK05573, rplU, 50S ribosomal protein L21; Validated
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	5	2376256-2376940	1,3,5	CRT,PILER-CR,CRISPRCasFinder	no	casR,cas6,cas7,cas5,cas3,cas4,cas1,cas2	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Unclear	GGTCGTCATCAACCCAGGAGGGTTCGCAAC,GTCGTCATCAACCCAGGAGGGTTCGCAAC,GTCGTCATCAACCCAGGAGGGTTCGCAAC	30,29,29	0	0	NA	NA	NA:NA:NA	10,10,10	10	Unclear	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|234aa|up_7|NZ_CP042266.1_2365791_2366493_-,NA|117aa|up_4|NZ_CP042266.1_2368731_2369082_+,NA|442aa|down_4|NZ_CP042266.1_2380845_2382171_-,NA|64aa|down_6|NZ_CP042266.1_2383918_2384110_+,NA|473aa|down_9|NZ_CP042266.1_2388012_2389431_+	NA|135aa|up_9|NZ_CP042266.1_2364499_2364904_+	cd14771, TrHb2_Mt-trHbO-like_O, Truncated hemoglobins, group 2 (O); Mycobacterium tuberculosis hemoglobin O like	casR|248aa|up_8|NZ_CP042266.1_2364991_2365735_-	COG1414, IclR, Transcriptional regulator [Transcription]	NA|234aa|up_7|NZ_CP042266.1_2365791_2366493_-	NA	NA|147aa|up_6|NZ_CP042266.1_2366489_2366930_-	COG0824, FcbC, Predicted thioesterase [General function prediction only]	NA|555aa|up_5|NZ_CP042266.1_2367080_2368745_-	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed	NA|117aa|up_4|NZ_CP042266.1_2368731_2369082_+	NA	NA|487aa|up_3|NZ_CP042266.1_2369082_2370543_-	pfam08341, TED, Thioester domain	NA|161aa|up_2|NZ_CP042266.1_2371301_2371784_-	PRK07772, PRK07772, single-stranded DNA-binding protein; Provisional	NA|565aa|up_1|NZ_CP042266.1_2371894_2373589_-	cd11383, YfjP, YfjP GTPase	NA|531aa|up_0|NZ_CP042266.1_2373728_2375321_-	pfam00350, Dynamin_N, Dynamin family	NA|323aa|down_0|NZ_CP042266.1_2377148_2378117_-	pfam01266, DAO, FAD dependent oxidoreductase	NA|310aa|down_1|NZ_CP042266.1_2378554_2379484_-	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]	NA|190aa|down_2|NZ_CP042266.1_2379497_2380067_-	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle	NA|181aa|down_3|NZ_CP042266.1_2380292_2380835_-	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]	NA|442aa|down_4|NZ_CP042266.1_2380845_2382171_-	NA	NA|246aa|down_5|NZ_CP042266.1_2382363_2383101_+	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X	NA|64aa|down_6|NZ_CP042266.1_2383918_2384110_+	NA	NA|92aa|down_7|NZ_CP042266.1_2384174_2384450_-	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins	cas6|231aa|down_8|NZ_CP042266.1_2387332_2388025_+	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6	NA|473aa|down_9|NZ_CP042266.1_2388012_2389431_+	NA
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	6	2385360-2386831	4,6,2	PILER-CR,CRISPRCasFinder,CRT	no	cas6,cas7,cas5,cas3,cas4,cas1,cas2,cas6e,cse2gr11	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Unclear	GTCGTCATCAACCCAGGAGGGTTCGCAAC,GTCGTCATCAACCCAGGAGGGTTCGCAAC,GTCGTCATCAACCCAGGAGGGTTCGCAAC	29,29,29	0	0	NA	NA	NA:NA:NA	22,22,22	22	Unclear	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|442aa|up_3|NZ_CP042266.1_2380845_2382171_-,NA|64aa|up_1|NZ_CP042266.1_2383918_2384110_+,NA|473aa|down_1|NZ_CP042266.1_2388012_2389431_+,NA|228aa|down_8|NZ_CP042266.1_2395971_2396655_-	NA|565aa|up_9|NZ_CP042266.1_2371894_2373589_-	cd11383, YfjP, YfjP GTPase	NA|531aa|up_8|NZ_CP042266.1_2373728_2375321_-	pfam00350, Dynamin_N, Dynamin family	NA|323aa|up_7|NZ_CP042266.1_2377148_2378117_-	pfam01266, DAO, FAD dependent oxidoreductase	NA|310aa|up_6|NZ_CP042266.1_2378554_2379484_-	COG0492, TrxB, Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]	NA|190aa|up_5|NZ_CP042266.1_2379497_2380067_-	cd00431, cysteine_hydrolases, Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle	NA|181aa|up_4|NZ_CP042266.1_2380292_2380835_-	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]	NA|442aa|up_3|NZ_CP042266.1_2380845_2382171_-	NA	NA|246aa|up_2|NZ_CP042266.1_2382363_2383101_+	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X	NA|64aa|up_1|NZ_CP042266.1_2383918_2384110_+	NA	NA|92aa|up_0|NZ_CP042266.1_2384174_2384450_-	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins	cas6|231aa|down_0|NZ_CP042266.1_2387332_2388025_+	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6	NA|473aa|down_1|NZ_CP042266.1_2388012_2389431_+	NA	cas7|352aa|down_2|NZ_CP042266.1_2389430_2390486_+	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7	cas5|233aa|down_3|NZ_CP042266.1_2390482_2391181_+	cd09693, Cas5_I, CRISPR/Cas system-associated RAMP superfamily protein Cas5	cas3|809aa|down_4|NZ_CP042266.1_2391162_2393589_+	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms]	cas4|174aa|down_5|NZ_CP042266.1_2393585_2394107_+	pfam01930, Cas_Cas4, Domain of unknown function DUF83	cas1|327aa|down_6|NZ_CP042266.1_2394106_2395087_+	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP	cas2|88aa|down_7|NZ_CP042266.1_2395093_2395357_+	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2	NA|228aa|down_8|NZ_CP042266.1_2395971_2396655_-	NA	NA|425aa|down_9|NZ_CP042266.1_2397074_2398349_+	pfam05048, NosD, Periplasmic copper-binding protein (NosD)
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	7	2395448-2395879	5,7,3	PILER-CR,CRISPRCasFinder,CRT	no	cas6,cas7,cas5,cas3,cas4,cas1,cas2,cas6e,cse2gr11,cas8e	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Type I-E	GGTCGTCATCAACCCAGGAGGGTTCGCAA,GGTCGTCATCAACCCAGGAGGGTTCGCAAC,GTCGTCATCAACCCAGGAGGGTTCGCAA	29,30,28	0	0	NA	NA	NA:NA:NA	5,5,6	6	TypeI-E	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|64aa|up_9|NZ_CP042266.1_2383918_2384110_+,NA|473aa|up_6|NZ_CP042266.1_2388012_2389431_+,NA|228aa|down_0|NZ_CP042266.1_2395971_2396655_-,NA|60aa|down_9|NZ_CP042266.1_2407329_2407509_-	NA|64aa|up_9|NZ_CP042266.1_2383918_2384110_+	NA	NA|92aa|up_8|NZ_CP042266.1_2384174_2384450_-	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins	cas6|231aa|up_7|NZ_CP042266.1_2387332_2388025_+	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6	NA|473aa|up_6|NZ_CP042266.1_2388012_2389431_+	NA	cas7|352aa|up_5|NZ_CP042266.1_2389430_2390486_+	cd09687, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7	cas5|233aa|up_4|NZ_CP042266.1_2390482_2391181_+	cd09693, Cas5_I, CRISPR/Cas system-associated RAMP superfamily protein Cas5	cas3|809aa|up_3|NZ_CP042266.1_2391162_2393589_+	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms]	cas4|174aa|up_2|NZ_CP042266.1_2393585_2394107_+	pfam01930, Cas_Cas4, Domain of unknown function DUF83	cas1|327aa|up_1|NZ_CP042266.1_2394106_2395087_+	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP	cas2|88aa|up_0|NZ_CP042266.1_2395093_2395357_+	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2	NA|228aa|down_0|NZ_CP042266.1_2395971_2396655_-	NA	NA|425aa|down_1|NZ_CP042266.1_2397074_2398349_+	pfam05048, NosD, Periplasmic copper-binding protein (NosD)	NA|525aa|down_2|NZ_CP042266.1_2398416_2399991_-	pfam13229, Beta_helix, Right handed beta helix region	NA|569aa|down_3|NZ_CP042266.1_2400373_2402080_+	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily	cas6e|250aa|down_4|NZ_CP042266.1_2401973_2402723_-	pfam08798, CRISPR_assoc, CRISPR associated protein	cas5|301aa|down_5|NZ_CP042266.1_2402704_2403607_-	pfam09704, Cas_Cas5d, CRISPR-associated protein (Cas_Cas5)	cas7|470aa|down_6|NZ_CP042266.1_2403603_2405013_-	pfam09344, Cas_CT1975, CT1975-like protein	cse2gr11|186aa|down_7|NZ_CP042266.1_2405009_2405567_-	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2)	cas8e|519aa|down_8|NZ_CP042266.1_2405563_2407120_-	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1)	NA|60aa|down_9|NZ_CP042266.1_2407329_2407509_-	NA
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	8	2448094-2448238	4	CRT	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	GGACGCGGTGCCGGGGGC	18	1	5	2448112-2448129|2448112-2448129|2448112-2448129|2448112-2448129|2448112-2448129	NZ_CP042266.1_1912257-1912274|NZ_CP042266.1_2994214-2994231|NZ_CP042266.1_1210918-1210901|NZ_CP042266.1_3923516-3923499|NZ_CP042266.1_4970177-4970160	NA	3	3	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA,NA	NA|266aa|up_9|NZ_CP042266.1_2430538_2431336_+	pfam12147, Methyltransf_20, Putative methyltransferase	NA|206aa|up_8|NZ_CP042266.1_2431706_2432324_+	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon	NA|289aa|up_7|NZ_CP042266.1_2432371_2433238_-	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]	NA|932aa|up_6|NZ_CP042266.1_2433234_2436030_-	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms]	NA|1469aa|up_5|NZ_CP042266.1_2436530_2440937_+	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau	NA|522aa|up_4|NZ_CP042266.1_2440942_2442508_+	pfam13191, AAA_16, AAA ATPase domain	NA|501aa|up_3|NZ_CP042266.1_2442605_2444108_-	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2	NA|631aa|up_2|NZ_CP042266.1_2444186_2446079_-	TIGR04377, 3D-35/4-trihydroxycyclohexane-12-dione_hydrolase, 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase	NA|348aa|up_1|NZ_CP042266.1_2446075_2447119_-	pfam04962, KduI, KduI/IolB family	NA|295aa|up_0|NZ_CP042266.1_2447197_2448082_-	cd00958, DhnA, Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs)	NA|304aa|down_0|NZ_CP042266.1_2449380_2450292_+	TIGR04379, myo-inositol_catabolism_protein, myo-inosose-2 dehydratase	NA|66aa|down_1|NZ_CP042266.1_2450574_2450772_+	PHA02519, PHA02519, plasmid partition protein SopA; Reviewed	NA|193aa|down_2|NZ_CP042266.1_2450969_2451548_+	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]	NA|104aa|down_3|NZ_CP042266.1_2451725_2452037_+	COG2608, CopZ, Copper chaperone [Inorganic ion transport and metabolism]	NA|430aa|down_4|NZ_CP042266.1_2452751_2454041_-	PRK05614, gltA, citrate synthase	NA|739aa|down_5|NZ_CP042266.1_2454270_2456487_-	TIGR01448, recD_rel, helicase, putative, RecD/TraA family	NA|268aa|down_6|NZ_CP042266.1_2456624_2457428_-	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]	NA|384aa|down_7|NZ_CP042266.1_2457485_2458637_-	pfam06187, DUF993, Protein of unknown function (DUF993)	NA|384aa|down_8|NZ_CP042266.1_2458633_2459785_-	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only]	NA|354aa|down_9|NZ_CP042266.1_2460086_2461148_+	COG1609, PurR, Transcriptional regulators [Transcription]
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	9	2633381-2633650	8	CRISPRCasFinder	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	GTGCTCCCCGCGCACGCGGGGATGGTCC	28	0	0	NA	NA	I-E	4	4	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|141aa|up_9|NZ_CP042266.1_2623859_2624282_-,NA|171aa|up_2|NZ_CP042266.1_2630968_2631481_+,NA|86aa|up_1|NZ_CP042266.1_2631477_2631735_+,NA|154aa|down_1|NZ_CP042266.1_2635627_2636089_-,NA|524aa|down_7|NZ_CP042266.1_2642378_2643950_-	NA|141aa|up_9|NZ_CP042266.1_2623859_2624282_-	NA	NA|668aa|up_8|NZ_CP042266.1_2624468_2626472_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|241aa|up_7|NZ_CP042266.1_2626455_2627178_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|382aa|up_6|NZ_CP042266.1_2627277_2628423_-	TIGR01263, 4-hydroxyphenylpyruvate_dioxygenase, 4-hydroxyphenylpyruvate dioxygenase	NA|156aa|up_5|NZ_CP042266.1_2628544_2629012_+	COG1522, Lrp, Transcriptional regulators [Transcription]	NA|263aa|up_4|NZ_CP042266.1_2629008_2629797_-	COG3480, SdrC, Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]	NA|214aa|up_3|NZ_CP042266.1_2629834_2630476_-	COG1414, IclR, Transcriptional regulator [Transcription]	NA|171aa|up_2|NZ_CP042266.1_2630968_2631481_+	NA	NA|86aa|up_1|NZ_CP042266.1_2631477_2631735_+	NA	NA|411aa|up_0|NZ_CP042266.1_2631721_2632954_-	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system	NA|597aa|down_0|NZ_CP042266.1_2633652_2635443_-	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]	NA|154aa|down_1|NZ_CP042266.1_2635627_2636089_-	NA	NA|476aa|down_2|NZ_CP042266.1_2636676_2638104_+	pfam12844, HTH_19, Helix-turn-helix domain	NA|290aa|down_3|NZ_CP042266.1_2638103_2638973_+	cd05153, HomoserineK_II, Type II Homoserine Kinase	NA|410aa|down_4|NZ_CP042266.1_2638977_2640207_-	COG1396, HipB, Predicted transcriptional regulators [Transcription]	NA|215aa|down_5|NZ_CP042266.1_2640334_2640979_-	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism]	NA|395aa|down_6|NZ_CP042266.1_2641031_2642216_-	pfam00144, Beta-lactamase, Beta-lactamase	NA|524aa|down_7|NZ_CP042266.1_2642378_2643950_-	NA	NA|113aa|down_8|NZ_CP042266.1_2644189_2644528_+	pfam03091, CutA1, CutA1 divalent ion tolerance protein	NA|180aa|down_9|NZ_CP042266.1_2644560_2645100_+	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	10	3619003-3619536	5	CRT	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	NCGNTCGTCACGNCGGTC	18	0	0	NA	NA	NA	9	9	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|405aa|up_3|NZ_CP042266.1_3611108_3612323_+,NA|146aa|up_2|NZ_CP042266.1_3612745_3613183_-,NA	NA|180aa|up_9|NZ_CP042266.1_3605164_3605704_-	PRK00416, dcd, deoxycytidine triphosphate deaminase; Reviewed	NA|406aa|up_8|NZ_CP042266.1_3605700_3606918_-	COG0737, UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]	NA|428aa|up_7|NZ_CP042266.1_3606914_3608198_-	COG0766, MurA, UDP-N-acetylglucosamine enolpyruvyl transferase [Cell envelope biogenesis, outer membrane]	NA|142aa|up_6|NZ_CP042266.1_3608246_3608672_-	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains	NA|425aa|up_5|NZ_CP042266.1_3608846_3610121_+	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins	NA|186aa|up_4|NZ_CP042266.1_3610117_3610675_+	pfam02441, Flavoprotein, Flavoprotein	NA|405aa|up_3|NZ_CP042266.1_3611108_3612323_+	NA	NA|146aa|up_2|NZ_CP042266.1_3612745_3613183_-	NA	NA|334aa|up_1|NZ_CP042266.1_3613344_3614346_-	pfam00665, rve, Integrase core domain	NA|1049aa|up_0|NZ_CP042266.1_3615657_3618804_-	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	NA|193aa|down_0|NZ_CP042266.1_3621504_3622083_-	PRK12323, PRK12323, DNA polymerase III subunit gamma/tau	NA|121aa|down_1|NZ_CP042266.1_3622333_3622696_-	COG0239, CrcB, Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]	NA|171aa|down_2|NZ_CP042266.1_3622692_3623205_-	pfam02537, CRCB, CrcB-like protein, Camphor Resistance (CrcB)	NA|117aa|down_3|NZ_CP042266.1_3623425_3623776_+	cd12952, MMP_ACEL2062, Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein	NA|572aa|down_4|NZ_CP042266.1_3624102_3625818_+	pfam00149, Metallophos, Calcineurin-like phosphoesterase	NA|283aa|down_5|NZ_CP042266.1_3626262_3627111_-	COG0785, CcdA, Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]	NA|273aa|down_6|NZ_CP042266.1_3627107_3627926_-	cd03023, DsbA_Com1_like, DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti	NA|129aa|down_7|NZ_CP042266.1_3628013_3628400_-	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	NA|1330aa|down_8|NZ_CP042266.1_3628509_3632499_+	PRK11131, PRK11131, ATP-dependent RNA helicase HrpA; Provisional	NA|69aa|down_9|NZ_CP042266.1_3633519_3633726_-	cd04762, HTH_MerR-trunc, Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	11	3909244-3909337	9	CRISPRCasFinder	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	TCGACCGGTCCGTCCTCCGTCAC	23	0	0	NA	NA	NA	1	1	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|251aa|up_4|NZ_CP042266.1_3903038_3903791_-,NA	NA|217aa|up_9|NZ_CP042266.1_3898458_3899109_+	pfam02254, TrkA_N, TrkA-N domain	NA|326aa|up_8|NZ_CP042266.1_3899175_3900153_+	cd05276, p53_inducible_oxidoreductase, PIG3 p53-inducible quinone oxidoreductase	NA|324aa|up_7|NZ_CP042266.1_3900311_3901283_-	pfam14015, DUF4231, Protein of unknown function (DUF4231)	NA|384aa|up_6|NZ_CP042266.1_3900901_3902053_-	cd07209, Pat_hypo_Ecoli_Z1214_like, Hypothetical patatin similar to Z1214 protein of Escherichia coli	NA|330aa|up_5|NZ_CP042266.1_3902052_3903042_-	pfam13990, YjcZ, YjcZ-like protein	NA|251aa|up_4|NZ_CP042266.1_3903038_3903791_-	NA	NA|618aa|up_3|NZ_CP042266.1_3903932_3905786_-	cd10229, HSPA12_like_NBD, Nucleotide-binding domain of HSPA12A, HSPA12B and similar proteins	NA|409aa|up_2|NZ_CP042266.1_3906149_3907376_-	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters	NA|336aa|up_1|NZ_CP042266.1_3907461_3908469_+	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors	NA|181aa|up_0|NZ_CP042266.1_3908524_3909067_-	pfam10759, DUF2587, Protein of unknown function (DUF2587)	NA|259aa|down_0|NZ_CP042266.1_3912238_3913015_-	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein	NA|218aa|down_1|NZ_CP042266.1_3913340_3913994_-	pfam03551, PadR, Transcriptional regulator PadR-like family	NA|230aa|down_2|NZ_CP042266.1_3914115_3914805_-	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated	NA|629aa|down_3|NZ_CP042266.1_3915157_3917044_-	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins	NA|545aa|down_4|NZ_CP042266.1_3917504_3919139_+	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins	NA|346aa|down_5|NZ_CP042266.1_3919191_3920229_-	cd05153, HomoserineK_II, Type II Homoserine Kinase	NA|131aa|down_6|NZ_CP042266.1_3920244_3920637_-	pfam12900, Pyridox_ox_2, Pyridoxamine 5'-phosphate oxidase	NA|227aa|down_7|NZ_CP042266.1_3921266_3921947_-	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|403aa|down_8|NZ_CP042266.1_3922331_3923540_+	TIGR03181, PDH_E1_alph_x, pyruvate dehydrogenase E1 component, alpha subunit	NA|327aa|down_9|NZ_CP042266.1_3923542_3924523_+	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	12	4552688-4552773	10	CRISPRCasFinder	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	GCTGTAGCTGGACTTGAACCAGT	23	0	0	NA	NA	NA	1	1	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|78aa|up_7|NZ_CP042266.1_4545346_4545580_-,NA|76aa|up_6|NZ_CP042266.1_4545644_4545872_-,NA|213aa|down_3|NZ_CP042266.1_4555173_4555812_-	NA|320aa|up_9|NZ_CP042266.1_4542637_4543597_+	PRK00072, hemC, porphobilinogen deaminase; Reviewed	NA|555aa|up_8|NZ_CP042266.1_4543593_4545258_+	pfam02602, HEM4, Uroporphyrinogen-III synthase HemD	NA|78aa|up_7|NZ_CP042266.1_4545346_4545580_-	NA	NA|76aa|up_6|NZ_CP042266.1_4545644_4545872_-	NA	NA|184aa|up_5|NZ_CP042266.1_4546032_4546584_+	pfam12867, DinB_2, DinB superfamily	NA|330aa|up_4|NZ_CP042266.1_4546614_4547604_+	PRK09283, PRK09283, porphobilinogen synthase	NA|411aa|up_3|NZ_CP042266.1_4547746_4548979_+	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]	NA|459aa|up_2|NZ_CP042266.1_4549025_4550402_+	TIGR03105, gln_synth_III, glutamine synthetase, type III	NA|288aa|up_1|NZ_CP042266.1_4550515_4551379_+	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs	NA|315aa|up_0|NZ_CP042266.1_4551427_4552372_-	cd00325, chitinase_GH19, Glycoside hydrolase family 19, chitinase domain	NA|275aa|down_0|NZ_CP042266.1_4552785_4553610_-	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins	NA|145aa|down_1|NZ_CP042266.1_4553724_4554159_+	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains	NA|292aa|down_2|NZ_CP042266.1_4554142_4555018_-	COG2084, MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]	NA|213aa|down_3|NZ_CP042266.1_4555173_4555812_-	NA	NA|951aa|down_4|NZ_CP042266.1_4555900_4558753_+	COG2319, COG2319, FOG: WD40 repeat [General function prediction only]	NA|92aa|down_5|NZ_CP042266.1_4558831_4559107_+	pfam08962, DUF1876, Domain of unknown function (DUF1876)	NA|1349aa|down_6|NZ_CP042266.1_4559278_4563325_+	COG3325, ChiA, Chitinase [Carbohydrate transport and metabolism]	NA|592aa|down_7|NZ_CP042266.1_4563389_4565165_-	PLN02286, PLN02286, arginine-tRNA ligase	NA|577aa|down_8|NZ_CP042266.1_4565439_4567170_+	PRK00750, lysK, lysyl-tRNA synthetase; Reviewed	NA|342aa|down_9|NZ_CP042266.1_4567560_4568586_-	cd00530, PTE, Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	13	4978798-4978945	11	CRISPRCasFinder	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	GCCTCGACCCCGCGCCCGCGGGGATG	26	0	0	NA	NA	NA	2	2	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|103aa|up_6|NZ_CP042266.1_4967804_4968113_-,NA|162aa|up_1|NZ_CP042266.1_4977310_4977796_-,NA|144aa|down_0|NZ_CP042266.1_4979534_4979966_-,NA|371aa|down_4|NZ_CP042266.1_4982233_4983346_-,NA|71aa|down_7|NZ_CP042266.1_4985078_4985291_-	NA|270aa|up_9|NZ_CP042266.1_4963096_4963906_+	PRK07657, PRK07657, enoyl-CoA hydratase; Provisional	NA|462aa|up_8|NZ_CP042266.1_4963976_4965362_+	smart00267, GGDEF, diguanylate cyclase	NA|515aa|up_7|NZ_CP042266.1_4966194_4967739_+	PRK09367, PRK09367, histidine ammonia-lyase; Provisional	NA|103aa|up_6|NZ_CP042266.1_4967804_4968113_-	NA	NA|423aa|up_5|NZ_CP042266.1_4968559_4969828_+	pfam17964, Big_10, Bacterial Ig domain	NA|574aa|up_4|NZ_CP042266.1_4969921_4971643_-	pfam09594, GT87, Glycosyltransferase family 87	NA|583aa|up_3|NZ_CP042266.1_4971670_4973419_-	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]	NA|1115aa|up_2|NZ_CP042266.1_4973732_4977077_-	cd07487, Peptidases_S8_1, Peptidase S8 family domain, uncharacterized subfamily 1	NA|162aa|up_1|NZ_CP042266.1_4977310_4977796_-	NA	NA|65aa|up_0|NZ_CP042266.1_4978258_4978453_+	pfam16686, POT1PC, ssDNA-binding domain of telomere protection protein	NA|144aa|down_0|NZ_CP042266.1_4979534_4979966_-	NA	NA|248aa|down_1|NZ_CP042266.1_4980084_4980828_+	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins	NA|157aa|down_2|NZ_CP042266.1_4980830_4981301_+	cd04676, Nudix_Hydrolase_17, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X	NA|226aa|down_3|NZ_CP042266.1_4981315_4981993_-	PRK00058, PRK00058, peptide-methionine (S)-S-oxide reductase MsrA	NA|371aa|down_4|NZ_CP042266.1_4982233_4983346_-	NA	NA|386aa|down_5|NZ_CP042266.1_4983487_4984645_+	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional	NA|64aa|down_6|NZ_CP042266.1_4984783_4984975_-	pfam06348, DUF1059, Protein of unknown function (DUF1059)	NA|71aa|down_7|NZ_CP042266.1_4985078_4985291_-	NA	NA|141aa|down_8|NZ_CP042266.1_4985326_4985749_-	TIGR02983, putative_RNA_polymerase_ECF-subfamily_sigma_factor, RNA polymerase sigma-70 factor, sigma-E family	NA|168aa|down_9|NZ_CP042266.1_4986202_4986706_-	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	14	5362847-5363008	12	CRISPRCasFinder	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	CGCCGATCTCTCCGGCGCCGATCTGCG	27	0	0	NA	NA	NA	2	2	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|198aa|up_6|NZ_CP042266.1_5353750_5354344_-,NA|447aa|up_5|NZ_CP042266.1_5354396_5355737_-,NA|305aa|up_3|NZ_CP042266.1_5356643_5357558_-,NA|264aa|down_2|NZ_CP042266.1_5364856_5365648_-,NA|95aa|down_9|NZ_CP042266.1_5374059_5374344_-	NA|349aa|up_9|NZ_CP042266.1_5350786_5351833_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|247aa|up_8|NZ_CP042266.1_5352027_5352768_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|235aa|up_7|NZ_CP042266.1_5352859_5353564_-	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism]	NA|198aa|up_6|NZ_CP042266.1_5353750_5354344_-	NA	NA|447aa|up_5|NZ_CP042266.1_5354396_5355737_-	NA	NA|260aa|up_4|NZ_CP042266.1_5355828_5356608_-	cd03264, ABC_drug_resistance_like, ABC-type multidrug transport system, ATPase component	NA|305aa|up_3|NZ_CP042266.1_5356643_5357558_-	NA	NA|204aa|up_2|NZ_CP042266.1_5357704_5358316_-	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]	NA|168aa|up_1|NZ_CP042266.1_5358383_5358887_-	pfam08974, DUF1877, Domain of unknown function (DUF1877)	NA|805aa|up_0|NZ_CP042266.1_5359075_5361490_+	COG0466, Lon, ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]	NA|289aa|down_0|NZ_CP042266.1_5363213_5364080_-	cd06412, GH25_CH-type, CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans	NA|161aa|down_1|NZ_CP042266.1_5364315_5364798_+	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein	NA|264aa|down_2|NZ_CP042266.1_5364856_5365648_-	NA	NA|1044aa|down_3|NZ_CP042266.1_5366140_5369272_+	pfam08376, NIT, Nitrate and nitrite sensing	NA|161aa|down_4|NZ_CP042266.1_5369268_5369751_+	smart00960, Robl_LC7, Roadblock/LC7 domain	NA|143aa|down_5|NZ_CP042266.1_5369747_5370176_+	pfam05331, DUF742, Protein of unknown function (DUF742)	NA|203aa|down_6|NZ_CP042266.1_5370270_5370879_+	COG2229, COG2229, Predicted GTPase [General function prediction only]	NA|419aa|down_7|NZ_CP042266.1_5371005_5372262_+	pfam17885, Smoa_sbd, Styrene monooxygenase A putative substrate binding domain	NA|390aa|down_8|NZ_CP042266.1_5372423_5373593_-	pfam00877, NLPC_P60, NlpC/P60 family	NA|95aa|down_9|NZ_CP042266.1_5374059_5374344_-	NA
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	15	5809471-5809562	13	CRISPRCasFinder	no		csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Orphan	GGTACGGCCGCGTTCGCGGCGGC	23	0	0	NA	NA	NA	1	1	Orphan	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|140aa|up_9|NZ_CP042266.1_5799544_5799964_+,NA|66aa|up_6|NZ_CP042266.1_5801058_5801256_+,NA|66aa|up_5|NZ_CP042266.1_5801252_5801450_+,NA|236aa|down_1|NZ_CP042266.1_5811673_5812381_-,NA|159aa|down_5|NZ_CP042266.1_5816914_5817391_+	NA|140aa|up_9|NZ_CP042266.1_5799544_5799964_+	NA	NA|70aa|up_8|NZ_CP042266.1_5800097_5800307_+	pfam04149, DUF397, Domain of unknown function (DUF397)	NA|88aa|up_7|NZ_CP042266.1_5800491_5800755_-	COG2188, PhnF, Transcriptional regulators [Transcription]	NA|66aa|up_6|NZ_CP042266.1_5801058_5801256_+	NA	NA|66aa|up_5|NZ_CP042266.1_5801252_5801450_+	NA	NA|327aa|up_4|NZ_CP042266.1_5801744_5802725_-	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|331aa|up_3|NZ_CP042266.1_5802682_5803675_-	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|296aa|up_2|NZ_CP042266.1_5803671_5804559_-	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|330aa|up_1|NZ_CP042266.1_5804555_5805545_-	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]	NA|624aa|up_0|NZ_CP042266.1_5805638_5807510_-	cd00995, PBP2_NikA_DppA_OppA_like, The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold	NA|78aa|down_0|NZ_CP042266.1_5811119_5811353_-	pfam04149, DUF397, Domain of unknown function (DUF397)	NA|236aa|down_1|NZ_CP042266.1_5811673_5812381_-	NA	NA|390aa|down_2|NZ_CP042266.1_5812377_5813547_-	TIGR03923, T7SS_EccE, type VII secretion protein EccE	NA|507aa|down_3|NZ_CP042266.1_5813934_5815455_+	pfam05108, T7SS_ESX1_EccB, Type VII secretion system ESX-1, transport TM domain B	NA|403aa|down_4|NZ_CP042266.1_5815538_5816747_+	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin	NA|159aa|down_5|NZ_CP042266.1_5816914_5817391_+	NA	NA|590aa|down_6|NZ_CP042266.1_5817394_5819164_+	PHA03247, PHA03247, large tegument protein UL36; Provisional	NA|419aa|down_7|NZ_CP042266.1_5819189_5820446_+	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin	NA|122aa|down_8|NZ_CP042266.1_5820514_5820880_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target	NA|100aa|down_9|NZ_CP042266.1_5820945_5821245_+	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target
GCF_007856155.1_ASM785615v1	NZ_CP042266	Streptomyces sp. SSL-25 chromosome, complete genome	16	7607043-7607970	6,14,6	PILER-CR,CRISPRCasFinder,CRT	no	cas3,cas8e,cse2gr11,cas7,cas5,cas6e,cas1,cas2	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	Type I-E	CGGAACACCCCCACGCGGTGGGGAGGAC,CGGAACACCCCCACGCGGTGGGGAGGAC,CGGAACACCCCCACGCGGTGGGGAGGAC	28,28,28	0	0	NA	NA	NA:NA:NA	15,15,15	15	TypeI-E	csa3,RT,WYL,DEDDh,cas4,c2c9_V-U4,casR,cas6,cas7,cas5,cas3,cas1,cas2,cas6e,cse2gr11,cas8e,DinG	NA|214aa|up_7|NZ_CP042266.1_7596907_7597549_-,NA|103aa|down_8|NZ_CP042266.1_7619272_7619581_+,NA|132aa|down_9|NZ_CP042266.1_7619668_7620064_+	NA|252aa|up_9|NZ_CP042266.1_7594110_7594866_-	smart00020, Tryp_SPc, Trypsin-like serine protease	NA|520aa|up_8|NZ_CP042266.1_7595162_7596722_+	cd05245, SDR_a2, atypical (a) SDRs, subgroup 2	NA|214aa|up_7|NZ_CP042266.1_7596907_7597549_-	NA	NA|479aa|up_6|NZ_CP042266.1_7597548_7598985_-	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms]	NA|228aa|up_5|NZ_CP042266.1_7599173_7599857_-	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]	NA|600aa|up_4|NZ_CP042266.1_7599888_7601688_-	cd13123, MATE_MurJ_like, MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins	NA|399aa|up_3|NZ_CP042266.1_7601612_7602809_-	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]	NA|405aa|up_2|NZ_CP042266.1_7603173_7604388_+	pfam17964, Big_10, Bacterial Ig domain	NA|112aa|up_1|NZ_CP042266.1_7604464_7604800_-	sd00006, TPR, Tetratricopeptide repeat	NA|322aa|up_0|NZ_CP042266.1_7604978_7605944_+	COG1741, COG1741, Pirin-related protein [General function prediction only]	cas3|948aa|down_0|NZ_CP042266.1_7608208_7611052_+	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3	cas8e|529aa|down_1|NZ_CP042266.1_7611679_7613266_+	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1	cse2gr11|192aa|down_2|NZ_CP042266.1_7613427_7614003_+	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2)	cas7|378aa|down_3|NZ_CP042266.1_7613999_7615133_+	pfam09344, Cas_CT1975, CT1975-like protein	cas5|257aa|down_4|NZ_CP042266.1_7615129_7615900_+	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI	cas6e|217aa|down_5|NZ_CP042266.1_7615896_7616547_+	pfam08798, CRISPR_assoc, CRISPR associated protein	cas1|314aa|down_6|NZ_CP042266.1_7616603_7617545_+	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI	cas2|106aa|down_7|NZ_CP042266.1_7617544_7617862_+	pfam09707, Cas_Cas2CT1978, CRISPR-associated protein (Cas_Cas2CT1978)	NA|103aa|down_8|NZ_CP042266.1_7619272_7619581_+	NA	NA|132aa|down_9|NZ_CP042266.1_7619668_7620064_+	NA
