LOCUS       NC_001332               6744 bp ss-DNA     circular PHG 13-AUG-2018
DEFINITION  Enterobacteria phage I2-2, complete genome.
ACCESSION   NC_001332
VERSION     NC_001332.1
DBLINK      BioProject: PRJNA485481
KEYWORDS    RefSeq; genome; unidentified reading frame.
SOURCE      Escherichia virus I22
  ORGANISM  Escherichia virus I22
            Viruses; ssDNA viruses; Inoviridae; Lineavirus.
REFERENCE   1  (bases 1 to 6744)
  AUTHORS   Stassen,A.P., Schoenmakers,E.F., Yu,M., Schoenmakers,J.G. and
            Konings,R.N.
  TITLE     Nucleotide sequence of the genome of the filamentous bacteriophage
            I2-2: module evolution of the filamentous phage genome
  JOURNAL   J. Mol. Evol. 34 (2), 141-152 (1992)
   PUBMED   1556749
REFERENCE   2  (bases 1 to 6744)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2000) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 6744)
  AUTHORS   Konings,R.N.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-FEB-1989) Konings R.N.H., Laboratory of Molecular
            Biology, University of Nijmegen, Toernooiveld, 6525ED Nijmegen, The
            Netherlands
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X14336.
            This is a circular plasmid. Gene product I is encoded by an
            uninterrupted reading frame which overlaps the base assigned #1.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6744
                     /organism="Escherichia virus I22"
                     /mol_type="genomic DNA"
                     /host="Escherichia coli"
                     /db_xref="taxon:10869"
     gene            join(6631..6744,1..984)
                     /gene="I"
                     /locus_tag="I2-2p1"
                     /note="gene I"
                     /db_xref="GeneID:1260724"
     CDS             join(6631..6744,1..984)
                     /gene="I"
                     /locus_tag="I2-2p1"
                     /note="The pI protein of filamentous phages is involved in
                     morphogenesis and may hydrolyze ATP. It is an inner
                     membrane protein and interacts with the outer membrane
                     protein pIV. The N-termini of members of this cluster
                     share homology to the zonular occludens toxin (Zot)
                     encoded by phage CTXphi. However, the toxin activity of
                     Zot was mapped to the C terminus, which is divergent in
                     the proteins in this cluster. pXI is the product of
                     translational reinitiationin gene I and interacts with
                     pI."
                     /codon_start=1
                     /transl_table=11
                     /product="assembly protein"
                     /protein_id="NP_039622.1"
                     /db_xref="GOA:P15418"
                     /db_xref="InterPro:IPR008900"
                     /db_xref="UniProtKB/Swiss-Prot:P15418"
                     /db_xref="GeneID:1260724"
                     /translation="MAVYVVTGKLGAGKTLVAVSRIQRTLAKGGIVATNLNLKLHHFP
                     QVGRYAKQCRVMRIADKPTLEDLEAIGRGNLSYDESKNGLIVLDECGTWFNSRNWSDK
                     SRQPVIDWFLHARKLGWDVIFIIQDISLMDKQAREALAEHVVYCRRLDKLNIPIIGGL
                     ISVLSGGRLPLPKVHFGIVKYGDNPQSLTVDKWIYTGTDLYAAYDTKQIFTSDRELSP
                     PFCPVSPYYTHGIFAVKRDAKYYMRMTKIYFKKMNRVWLMASFLALGAGVGFFYKSRQ
                     INEQLSNMPVASAQANTTKTDHTIDELPRLSINSFAQMGYDVNVSFKDAKGKIYYSFD
                     LMKSGYALDIKDSCHITLRKRNYIQQVTCEG"
     gene            987..2273
                     /gene="IV"
                     /locus_tag="I2-2p2"
                     /note="gene IV"
                     /db_xref="GeneID:1260716"
     CDS             987..2273
                     /gene="IV"
                     /locus_tag="I2-2p2"
                     /note="pIV proteins of filamentous phages are multimeric
                     proteins that form a channel in the outer membrane through
                     which the phage particles exit the host cell. Function:
                     morphogenesis."
                     /codon_start=1
                     /transl_table=11
                     /product="phage assembly protein"
                     /protein_id="NP_039614.1"
                     /db_xref="GOA:P15420"
                     /db_xref="InterPro:IPR001775"
                     /db_xref="InterPro:IPR001814"
                     /db_xref="InterPro:IPR004845"
                     /db_xref="InterPro:IPR004846"
                     /db_xref="InterPro:IPR005644"
                     /db_xref="InterPro:IPR011662"
                     /db_xref="UniProtKB/Swiss-Prot:P15420"
                     /db_xref="GeneID:1260716"
                     /translation="MKTFFAKFIVALFAFTYFSAFAEPVTLNNSPVRSFVQWYSSKTG
                     KSVIVNPDVKGNITVFNADVNNANIDDFFKSVLNANGLVVVAGNPAVVSTPLTKLASQ
                     PSNEETYDDESDGVAYEAVPQSAAPAVPADLTVRNFNVTRVRSSDVLPLAKIFVDSNG
                     GGNVVDYPGNNSLVVSGSAQVMPALSDFITSIDVAREQVLIQSLMFETSVSNGVDLSF
                     ALALASGGKVAGGFNTSALGTALSTAGGSFGIFNGNILALSLQAVQSDSNSKVISTPR
                     ILTQSGQSGYISVGQNVPFVTGKVTGEAASVNNPFQTIERRDVGVSLKVTPVVMGNGQ
                     LVLTIDTKADSLSNQAIASDIITNQRQIQTTVQIKDGQTLLLGGLISSNQFDSDRSVP
                     FMSKIPLIGWLFRSHSDSKDDRTMFVLLTAHVIRAL"
     misc_feature    2260..2330
                     /note="morphogenetic signal"
     gene            3091..4125
                     /locus_tag="I2-2p3"
                     /note="gene II"
                     /db_xref="GeneID:1260717"
     CDS             3091..4125
                     /locus_tag="I2-2p3"
                     /note="The pII protein binds to the intergenic region in
                     double-stranded, supercoiled DNA (replicative form) and
                     nicks the positive strand. The resulting free 3' OH
                     terminus serves as a primer for new strand synthesis using
                     host factors (Rep helicase, DNA polymerase III). After a
                     full round of replication, pII circularizes the displaced
                     DNA strand. Newly synthesized (+) single stranded DNA is
                     either converted to RF DNA or packaged as genomes,
                     depending on the concentrations of ssDNA binding protein
                     pV and a separately expressed fragment of pII termed pX.
                     Functions: DNA replication initiation"
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="NP_039615.1"
                     /db_xref="GOA:P15419"
                     /db_xref="InterPro:IPR006516"
                     /db_xref="UniProtKB/Swiss-Prot:P15419"
                     /db_xref="GeneID:1260717"
                     /translation="MIDWVTAVLPCLHVPVDAGRVLSVAPDGSVEWESVKFSRVTGSF
                     QSSISVRSQGSDGNGKATHLYVDGNPSKWLQGHNIVGSDDLNGLMIAFYARMLSLLNI
                     PHHLESYRQVLSGQYELKRVDINYMFELPTLIDVRSWLHAAEFKAKTRHGRPATAKGT
                     LYFGKNSRRWSIKAYSKYDEVNCGKKAHGVPEEIKKTGLVEWSKNKLRLELTLRALQL
                     TDINLNFAKNWSTETAYTVFKEYMGRIEMSGNTLLTDTQVINLPSALRMTYVCWKQGI
                     CVTDMVSRATYFRHRKVLKEFGIDIAVTVDRVDNSNVVPLIRVLEAKPASIPSQYDNL
                     IFSSNRVSSF"
     gene            3829..4125
                     /gene="X"
                     /locus_tag="I2-2p4"
                     /note="gene X"
                     /db_xref="GeneID:1260718"
     CDS             3829..4125
                     /gene="X"
                     /locus_tag="I2-2p4"
                     /note="Protein pX is synthesized from an in-frame internal
                     initiation codon in gene II and is identical to the
                     C-terminal third of pII. Required for the accumulation of
                     (+) single stranded genomic DNA."
                     /codon_start=1
                     /transl_table=11
                     /product="gene X product"
                     /protein_id="NP_039616.1"
                     /db_xref="GOA:P15419"
                     /db_xref="UniProtKB/Swiss-Prot:P15419"
                     /db_xref="GeneID:1260718"
                     /translation="MSGNTLLTDTQVINLPSALRMTYVCWKQGICVTDMVSRATYFRH
                     RKVLKEFGIDIAVTVDRVDNSNVVPLIRVLEAKPASIPSQYDNLIFSSNRVSSF"
     gene            4136..4462
                     /locus_tag="I2-2p5"
                     /note="gene V"
                     /db_xref="GeneID:1260719"
     CDS             4136..4462
                     /locus_tag="I2-2p5"
                     /codon_start=1
                     /transl_table=11
                     /product="gene V product"
                     /protein_id="NP_039617.1"
                     /db_xref="GOA:P15417"
                     /db_xref="UniProtKB/Swiss-Prot:P15417"
                     /db_xref="GeneID:1260719"
                     /translation="MHSGILIRGRILGSRTANRDNNSPQHILGVGIQKADGFGGTTQD
                     VEQVKIPDQLVQSGVVNQINSLIGKLCEVPINVRSWSMNGKNGTSYTLSFESGIQEIE
                     ELIYVR"
     gene            4452..4541
                     /gene="VII"
                     /locus_tag="I2-2p6"
                     /note="gene VII"
                     /db_xref="GeneID:1260720"
     CDS             4452..4541
                     /gene="VII"
                     /locus_tag="I2-2p6"
                     /note="pVII minor coat proteins of E. coli filamentous
                     phages are located at the tip of the virion that first
                     emerges from the host cell."
                     /codon_start=1
                     /transl_table=11
                     /product="minor coat protein"
                     /protein_id="NP_039618.1"
                     /db_xref="GOA:P15413"
                     /db_xref="UniProtKB/Swiss-Prot:P15413"
                     /db_xref="GeneID:1260720"
                     /translation="MSDELIHVVIALGLVISFGLGAITAGVLR"
     gene            4538..4639
                     /gene="IX"
                     /locus_tag="I2-2p7"
                     /note="gene IX"
                     /db_xref="GeneID:1260721"
     CDS             4538..4639
                     /gene="IX"
                     /locus_tag="I2-2p7"
                     /note="pVII minor coat proteins of E. coli filamentous
                     phages are located at the tip of the virion that first
                     emerges from the host cell."
                     /codon_start=1
                     /transl_table=11
                     /product="minor coat protein"
                     /protein_id="NP_039619.1"
                     /db_xref="GOA:P15414"
                     /db_xref="UniProtKB/Swiss-Prot:P15414"
                     /db_xref="GeneID:1260721"
                     /translation="MIDYVGLFIGAYIMGFALFYGIGFFKSIAERIV"
     gene            4653..4907
                     /gene="VIII"
                     /locus_tag="I2-2p8"
                     /note="gene VIII"
                     /db_xref="GeneID:1260722"
     CDS             4653..4907
                     /gene="VIII"
                     /locus_tag="I2-2p8"
                     /note="Several thousand copies of the major coat protein
                     form the tube containing the ssDNA genome to form the
                     elongated body of filamentous phages."
                     /codon_start=1
                     /transl_table=11
                     /product="major coat protein"
                     /protein_id="NP_039620.1"
                     /db_xref="GOA:P15416"
                     /db_xref="InterPro:IPR008033"
                     /db_xref="UniProtKB/Swiss-Prot:P15416"
                     /db_xref="GeneID:1260722"
                     /translation="MSVITKVAAAKNKIVVGAGLLMASAGAFAADDGTSTATSYATEA
                     MNSLKTQATDLIDQTWPVVTSVAVAGLAIRLFKKFSSKAV"
     gene            4975..6279
                     /gene="III"
                     /locus_tag="I2-2p9"
                     /note="gene III"
                     /db_xref="GeneID:1260723"
     CDS             4975..6279
                     /gene="III"
                     /locus_tag="I2-2p9"
                     /note="Minor coat protein pIII is located at the tail of
                     the filamentous phage particle. It is involved in
                     termination of assembly and infectivity. In the absence of
                     pIII abnormally long phage particles are formed and remain
                     attached to host cells. In addition, pIII is involved in
                     initiating infection of host cells by binding to pili. In
                     the case of the Ff phages, pIII binds to the tip of F-pili
                     and then interacts with the TolA protein. The assembly
                     termination function maps to the C-terminus of pIII,
                     whereas the receptor binding maps to the N-terminus. Ike
                     and f1 proteins cannot replace one another. Functions:
                     receptor binding, morphogenesis, structural."
                     /codon_start=1
                     /transl_table=11
                     /product="attachment protein"
                     /protein_id="NP_039621.1"
                     /db_xref="GOA:P15415"
                     /db_xref="UniProtKB/Swiss-Prot:P15415"
                     /db_xref="GeneID:1260723"
                     /translation="MKRKIIAISLFLYIPLSNADNWESITKSYYTGFAMSKTVESKDQ
                     DGKTVRKEVITQADLTTACNDAKASAQDVFNQMKLTFSGIWPDSQFRLVTGDTCVYNG
                     SPSEKTESWSIRAQVEGDMQRSVPDEEPSEQTPEEICEAKPPIDGVFNNVSKGDEGGF
                     YINYNGCEYEATGVTVCQNDGTVCASSAWKPTGYVPESGESSSSPVKDGDTGGTGEGG
                     SDTGGDTGGGDTGGGSTGGDTGGSTGGGSTGGGSTGGSTGKSLTKEDVTAAIHDASPS
                     IGDAVKDSLTEDNDQNDNQKKADEQSAKASASVSDAISDGMRGVGNFVDDLGGESSQY
                     GIGNSEMDLSVSLAKGQLGIDLEGHGSAWESFLNDGALRPSIPSGHGCTDFVMFQGSV
                     YQLDIGCDKLGDIKSVLSWVMYCLTFWYVFQSATSLLRKGEQ"
ORIGIN      
        1 aagcttcatc atttcccgca ggtaggcaga tatgcaaaac aatgtcgtgt tatgcgcatt
       61 gcagacaagc ccactttaga ggatttagag gccattggtc gcggcaatct ttcttatgat
      121 gaatcaaaaa acggccttat tgttttagat gagtgtggca cgtggtttaa ttcccgcaac
      181 tggagtgata aaagtcgcca gcctgttata gactggtttt tacatgcccg taaattaggc
      241 tgggatgtaa tttttattat tcaggatatt tccctgatgg ataagcaggc acgcgaggct
      301 ttagccgaac atgttgttta ttgccgtcga ttagataaat taaatatacc tatcattggt
      361 ggtttaattt cggttctttc aggtggtaga ttgccattac cgaaagttca ctttggtatt
      421 gttaaatatg gtgataatcc tcagtcatta actgtagata aatggattta tactggtaca
      481 gatttatatg ctgcttacga tactaagcag atatttacca gtgaccgtga attaagcccg
      541 ccattctgcc ccgtttcgcc ttattacact catggcatat ttgccgttaa aagggatgct
      601 aaatattata tgcgtatgac aaaaatctat tttaagaaga tgaatcgtgt ttggttaatg
      661 gcttcctttc ttgctcttgg tgctggcgta gggttttttt ataaatctcg ccagataaat
      721 gagcaactat caaatatgcc tgtagcgtct gctcaggcta ataccactaa aacagatcac
      781 accattgatg aattgccacg attatcgatc aactcatttg cacaaatggg ttatgatgta
      841 aatgtaagtt ttaaagatgc aaagggaaaa atctattact catttgattt aatgaaatct
      901 ggttatgcct tagatattaa agattcctgt catattacat tgcgtaaacg aaactacatt
      961 cagcaagtta cttgtgaagg ctaattatga aaactttttt tgctaaattc atcgtcgctt
     1021 tatttgcttt tacttatttc tctgcattcg cggagcctgt tactttaaac aattctcctg
     1081 tgcgctcatt cgttcaatgg tattcatcca aaacaggaaa atcagttatt gttaaccctg
     1141 atgttaaggg gaatatcacc gtatttaatg ctgatgttaa caacgcaaat attgatgact
     1201 tttttaagtc tgtccttaat gctaacggcc ttgtagttgt cgctggtaat cctgccgttg
     1261 tttccacacc tttaactaag ctcgcgtcgc agccgtcaaa tgaagaaacc tatgatgatg
     1321 aaagtgacgg cgtagcgtat gaggcagtac cgcagtcggc tgcgcctgct gtacctgccg
     1381 atctcacggt acgtaatttc aacgtgacgc gcgttcgttc ttctgacgtt ctgccgctgg
     1441 ctaagatttt cgttgattca aatggcggcg gtaatgtcgt cgattaccca ggcaataaca
     1501 gtcttgttgt ttccggctca gctcaggtta tgcctgcttt atccgatttc attacgtcaa
     1561 ttgatgttgc ccgcgaacag gttctgattc agtccctgat gtttgaaacc agtgtttcta
     1621 atggcgtgga tctttctttt gcgctggctc tagcttctgg cggtaaagtt gcaggcggtt
     1681 ttaatacctc agctctcggc actgctcttt ctactgctgg cggtagcttc ggtatcttta
     1741 acggtaacat tctggcgtta tctctccagg ctgttcagag tgattctaac tctaaggtta
     1801 tctctacccc tcgcatcctc acgcagtccg gccagagtgg ttatatttca gttggccaga
     1861 atgttccttt tgtgacaggt aaagtcactg gcgaggctgc aagcgttaat aatcctttcc
     1921 agacaatcga gcgccgcgac gtaggcgtat cactaaaggt aacgccggtt gttatgggaa
     1981 atggtcagtt agttctcacc atcgatacta aagccgactc tctcagcaat caggcgattg
     2041 cctctgacat cattaccaat cagcgccaga tacaaaccac cgttcagatt aaagacggtc
     2101 agaccctgct tttaggcggc ctgattagct ctaaccagtt cgacagcgat cgttctgtgc
     2161 cttttatgtc gaagattcct ttaatcggct ggcttttccg cagccattca gactcgaaag
     2221 atgatcgcac tatgttcgtt ttgcttactg ctcacgttat cagggcgctt tgagggtgcg
     2281 gggtaggtgc gttagccctg ccccgtatcc tcacagcgtc ccctgacccg tatcattcgc
     2341 ttatcgccgt atgtgcttcc ctgtcttgtc cctaaggcta cgtattgcct ccccgtttaa
     2401 atcgtcaagc tataaatcgt gggggcccca tcgccctgtt aagctgcctt ttttcctgcg
     2461 atcctcccgc ctctctgttg tctgacggtc gcagacgaac aggacgttac agccattgtt
     2521 tttcgttctg ctggcttctt tttttggggg gtgtactctt gttgcaaaat cgcaacgcag
     2581 cgggggttaa atcatgctgc acgaaagtct cactttcggg attttggttt ttggatttct
     2641 gctgcggagt caggcggggc ggggtgaacg tgcagtgtat gtaatactgc aacgtttgtc
     2701 tcaatctgat acctctctac taaacgcctc ctttcttttt aagctcttta atcattttct
     2761 tttctgctaa ttctgtatag ttttcaatga catagtttaa gtgaatctgt ccatgtgacc
     2821 tgtacgcccg tacttgtact aatcctgatc gcagtatcac tcaggttttt ctttttctcg
     2881 gtggtgatac tggctgttgt cctaactggt tttttcattt tatgcctttg aaaaatataa
     2941 agtttctacc gaaaataggt ttttaagcgt aatcttattg tcaatagatg taaaaatttt
     3001 tgttgcgcac gttatttttc acgctatcat gcctgcattg gatttcatct tgatacgtgt
     3061 atacacgtat acatcactaa gggaatgcgt atgattgatt gggttacagc cgtcttgcct
     3121 tgtctgcatg tgcctgttga tgctggtcgc gtcctctctg ttgcgccgga tggctctgta
     3181 gaatgggaat cagtaaagtt ttcccgcgtt actggctcct ttcaaagctc catcagtgta
     3241 cgttcgcagg gttctgacgg taatgggaaa gccactcatt tatacgttga tggtaacccg
     3301 tcaaagtggt tgcagggtca taatatcgtt ggaagcgacg atctcaacgg ccttatgatt
     3361 gctttttacg ctcgtatgtt gtcactactc aatatacctc accatctaga atcgtatcgt
     3421 caggtgcttt ctggtcagta cgagctaaag cgcgttgaca ttaactacat gtttgagctt
     3481 cctacgctca ttgatgtacg gtcatggtta catgctgctg agttcaaggc taagactcgt
     3541 cacgggcgcc cggcaactgc aaagggcact ctgtactttg gtaaaaattc tcgccgttgg
     3601 tctattaagg cttacagcaa atatgatgaa gtaaattgcg ggaaaaaagc tcatggcgtt
     3661 cccgaagaaa ttaagaaaac tggccttgtt gaatggtcta aaaataaatt acgtctagaa
     3721 ttaacattac gcgcattgca gcttactgat attaatttaa actttgctaa aaactggtct
     3781 actgaaactg catatactgt ttttaaagaa tatatggggc gtatcgaaat gagcggaaat
     3841 actttactta ctgatactca agttattaat ttaccgtctg cgctacgtat gacttatgtg
     3901 tgctggaaac agggcatttg tgtaacagat atggtatctc gcgccactta ttttcgtcac
     3961 cgcaaggttt taaaagaatt tggtattgat attgctgtta ctgttgatcg tgttgataat
     4021 agcaacgttg ttccgttaat ccgtgtctta gaggctaaac ctgcttctat tccttctcaa
     4081 tatgataatt taatattttc atctaatcgt gtatcaagtt tctaaggggt tttaaatgca
     4141 ctcaggtatt cttattcgtg gtcgtattct cggttctcgc actgcaaacc gtgataataa
     4201 ttcgccgcaa catattttag gcgttggcat tcagaaagct gacggttttg gcggtacgac
     4261 tcaggatgtt gagcaggtta aaattcctga ccagcttgtg caaagcggcg ttgttaatca
     4321 gattaattcg cttattggca aactttgcga agtaccgatt aatgttcgtt cttggtctat
     4381 gaacggcaaa aacggcactt cttacactct gtcttttgag tccggtattc aggagattga
     4441 agagctgatt tatgtcagat gaactaattc acgtagtaat agctctcggc ctcgttattt
     4501 ccttcggttt gggtgctatt actgctgggg tactccgatg attgactatg ttggtttatt
     4561 cattggcgct tatataatgg gcttcgccct tttctatggc ataggattct ttaaatccat
     4621 tgctgaacgc atcgtttaat taaggaatac acatgagcgt tattactaaa gttgctgctg
     4681 ctaaaaacaa aatcgttgtt ggtgctggcc tgctgatggc ttctgctggc gcgttcgctg
     4741 ctgatgacgg tacttctacc gctaccagct acgctactga agcaatgaac agcctgaaaa
     4801 ctcaggcaac tgatctcatt gatcagacgt ggcctgttgt aactagcgtt gccgttgctg
     4861 gtctggcaat tcgtcttttc aagaaattct cttctaaagc tgtttaatat tcagcgtttt
     4921 caaggggcgc tattgcgccc ttttttttta ctttaattca gctaaggtgt aattgtgaaa
     4981 agaaaaataa tagcaatttc tttattttta tacatccctt tgtctaatgc tgataattgg
     5041 gagtctatta ctaaaagcta ttatactggc tttgccatgt ctaaaactgt tgaatcaaaa
     5101 gatcaggatg gtaaaacagt tcgtaaagag gttataactc aggctgattt aactaccgcc
     5161 tgtaatgatg ctaaagcctc cgcgcaagat gtttttaatc aaatgaagct aacattttct
     5221 ggtatatggc ctgattctca gtttcgcctt gtaactggtg atacctgcgt ttataacggt
     5281 tcgcctagtg aaaaaactga aagttggtct attcgcgctc aggttgaggg tgatatgcaa
     5341 cgttctgtac cagatgaaga accttctgaa caaacgccag aagaaatctg tgaagcaaaa
     5401 cctcctattg atggcgtctt taataacgtc tctaagggtg acgaaggagg cttttatatt
     5461 aattataatg gctgcgaata tgaggcaact ggcgtcactg tttgccagaa tgatggaact
     5521 gtctgtgcct cctccgcttg gaagccaact ggttacgttc ccgaatctgg agaatcttcc
     5581 tcctctcctg tgaaagatgg tgacactggc ggtactggtg aaggtggttc tgatactggc
     5641 ggtgatactg gtggcggtga tactggtggt ggttctactg gcggcgatac tggcggttct
     5701 actggtggcg gttctactgg tggcggttct actggtggat caactggtaa atcactgaca
     5761 aaggaagatg taaccgcagc aatacatgat gcttcccctt ctattggtga tgctgttaaa
     5821 gattccctta cagaagataa tgaccagaac gacaatcaga agaaagcaga tgaacaatca
     5881 gctaaagcct ctgcttctgt atctgatgct atctctgatg gtatgcgtgg cgttggtaat
     5941 ttcgttgacg atcttggcgg tgagtcgtcg caatacggaa tcggtaattc tgaaatggat
     6001 ctctccgtta gcctggctaa agggcaactt ggaattgatc ttgaaggtca tggttcagct
     6061 tgggaatcct ttttaaatga cggtgcttta cgtccctcca ttccttctgg tcatggctgt
     6121 actgattttg tcatgtttca gggttctgtt tatcagcttg atattggctg cgataaatta
     6181 ggcgatatta agtctgtatt atcttgggtt atgtattgcc ttaccttctg gtatgtattc
     6241 cagtctgcta cttcattact tcgtaaaggt gaacaataat gccagcttta ttaggtattc
     6301 cggctttaat tcgtttcata atggggcttg tgcctcttgc tattggttat tttgctaagt
     6361 tcttaggcaa aattattacc cgtaatggct tgatggctgc tgccttgatt ggtgcgatcc
     6421 tttcatttgt cacctttgca attcagcttt taggcgatgc tttatcttct gcaatgggcg
     6481 gaatgcctgc tgattttgga aatttaatgt cctctgtatt acctgatggt acaacaactt
     6541 gtattacagt aattatagac taccagatag cggtctttgt tttcgatatt aaagatcgct
     6601 tactcggcat tgccaataag gtaatttgat atggctgttt atgttgttac cggaaaatta
     6661 ggcgcaggca agacgcttgt agctgtatcg cgtatacaaa ggactttagc taaaggtggt
     6721 attgttgcca ccaatctaaa ttta
//

