CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_ALTB01000009	Streptococcus agalactiae GB00206 ctg7180000004592, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000005	Streptococcus agalactiae GB00206 ctg7180000004588, whole genome shotgun sequence	0 crisprs	NA	0	0	0	1
NZ_ALTB01000033	Streptococcus agalactiae GB00206 ctg7180000004616, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000023	Streptococcus agalactiae GB00206 ctg7180000004606, whole genome shotgun sequence	1 crisprs	NA	2	3	0	0
NZ_ALTB01000029	Streptococcus agalactiae GB00206 ctg7180000004612, whole genome shotgun sequence	1 crisprs	NA	0	1	0	0
NZ_ALTB01000007	Streptococcus agalactiae GB00206 ctg7180000004590, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000016	Streptococcus agalactiae GB00206 ctg7180000004599, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000015	Streptococcus agalactiae GB00206 ctg7180000004598, whole genome shotgun sequence	0 crisprs	DEDDh	0	0	0	0
NZ_ALTB01000027	Streptococcus agalactiae GB00206 ctg7180000004610, whole genome shotgun sequence	0 crisprs	DinG	0	0	1	0
NZ_ALTB01000026	Streptococcus agalactiae GB00206 ctg7180000004609, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000017	Streptococcus agalactiae GB00206 ctg7180000004600, whole genome shotgun sequence	0 crisprs	cas3	0	0	1	0
NZ_ALTB01000028	Streptococcus agalactiae GB00206 ctg7180000004611, whole genome shotgun sequence	0 crisprs	csm6	0	0	0	0
NZ_ALTB01000006	Streptococcus agalactiae GB00206 ctg7180000004589, whole genome shotgun sequence	0 crisprs	NA	0	0	2	0
NZ_ALTB01000010	Streptococcus agalactiae GB00206 ctg7180000004593, whole genome shotgun sequence	0 crisprs	NA	0	0	1	0
NZ_ALTB01000018	Streptococcus agalactiae GB00206 ctg7180000004601, whole genome shotgun sequence	0 crisprs	NA	0	0	1	0
NZ_ALTB01000012	Streptococcus agalactiae GB00206 ctg7180000004595, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000011	Streptococcus agalactiae GB00206 ctg7180000004594, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000019	Streptococcus agalactiae GB00206 ctg7180000004602, whole genome shotgun sequence	0 crisprs	NA	0	0	1	0
NZ_ALTB01000004	Streptococcus agalactiae GB00206 ctg7180000004587, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000031	Streptococcus agalactiae GB00206 ctg7180000004614, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000013	Streptococcus agalactiae GB00206 ctg7180000004596, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000002	Streptococcus agalactiae GB00206 ctg7180000004585, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000001	Streptococcus agalactiae GB00206 ctg7180000004584, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000003	Streptococcus agalactiae GB00206 ctg7180000004586, whole genome shotgun sequence	0 crisprs	cas3	0	0	0	0
NZ_ALTB01000014	Streptococcus agalactiae GB00206 ctg7180000004597, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000020	Streptococcus agalactiae GB00206 ctg7180000004603, whole genome shotgun sequence	1 crisprs	NA	0	10	0	0
NZ_ALTB01000021	Streptococcus agalactiae GB00206 ctg7180000004604, whole genome shotgun sequence	0 crisprs	DEDDh	0	0	1	0
NZ_ALTB01000025	Streptococcus agalactiae GB00206 ctg7180000004608, whole genome shotgun sequence	0 crisprs	csa3	0	0	1	0
NZ_ALTB01000032	Streptococcus agalactiae GB00206 ctg7180000004615, whole genome shotgun sequence	0 crisprs	WYL,RT	0	0	0	0
NZ_ALTB01000022	Streptococcus agalactiae GB00206 ctg7180000004605, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000024	Streptococcus agalactiae GB00206 ctg7180000004607, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000008	Streptococcus agalactiae GB00206 ctg7180000004591, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_ALTB01000030	Streptococcus agalactiae GB00206 ctg7180000004613, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

79323 : 86527

uncultured_Caudovirales_phage(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001042655.1\|79323_80028_-	transglycosylase SLT domain-containing protein	A0A2H4J6C5	uncultured_Caudovirales_phage	4.2e-27	56.6
WP_000029068.1\|80133_80673_-	LysM peptidoglycan-binding domain-containing protein	A0A249XZV3	Enterococcus_phage	6.7e-17	45.8
WP_000359358.1\|80888_81683_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
WP_000510606.1\|81675_82518_-	energy-coupling factor transporter ATPase	W6JKT0	Anomala_cuprea_entomopoxvirus	2.5e-18	25.5
WP_000181757.1\|82493_83333_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	3.5e-20	30.0
WP_000976003.1\|83332_83875_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
WP_000217754.1\|83997_85281_-	insulinase family protein	A0A2K9V7S4	Bandra_megavirus	1.3e-21	33.3
WP_000706188.1\|85282_86527_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	3.7e-87	41.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_ALTB01000019

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 66596

Streptococcus_phage(64.81%)

protease,portal,holin,tRNA,integrase,terminase,head,transposase,tail

attL 6381:6396|attR 31527:31542

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000626435.1\|0_189_-\|transposase	transposase	NA	NA	NA	NA
WP_000113465.1\|692_2066_+	cell division protein FtsA	NA	NA	NA	NA
WP_000232006.1\|2087_3368_+	cell division protein FtsZ	NA	NA	NA	NA
WP_000981485.1\|3373_4048_+	YggS family pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
WP_001185366.1\|4059_4665_+	cell division protein SepF	NA	NA	NA	NA
WP_000604717.1\|4667_4922_+	YggT family protein	NA	NA	NA	NA
WP_000171105.1\|4923_5712_+	RNA-binding protein	NA	NA	NA	NA
WP_001131467.1\|5721_6492_+	DivIVA domain-containing protein	NA	NA	NA	NA
6381:6396	attL	NA	NA	NA	NA
WP_000768164.1\|6776_9569_+\|tRNA	isoleucine--tRNA ligase	A0A2H4UVG0	Bodo_saltans_virus	1.8e-68	26.1
WP_001237035.1\|9685_9988_-	DUF1827 family protein	NA	NA	NA	NA
WP_000184292.1\|10051_10507_-	NUDIX hydrolase	NA	NA	NA	NA
WP_000882549.1\|10692_12954_-\|protease	ATP-dependent Clp protease ATP-binding subunit	A0A2C9CYX3	Yersinia_phage	7.4e-126	39.4
WP_011058319.1\|13109_13214_+	hypothetical protein	NA	NA	NA	NA
WP_000443582.1\|13251_13482_+	DUF1797 family protein	NA	NA	NA	NA
WP_001011647.1\|13623_14316_+	amino acid ABC transporter permease	NA	NA	NA	NA
WP_000230134.1\|14308_15043_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-35	41.8
WP_001106845.1\|15329_17024_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	5.5e-126	42.6
WP_000137498.1\|17162_18017_+	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	A0A249XZQ2	Enterococcus_phage	1.5e-39	40.2
WP_000634981.1\|18013_18850_+	NAD(P)H-hydrate dehydratase	NA	NA	NA	NA
WP_001286939.1\|18975_20316_+	exodeoxyribonuclease VII large subunit	A0A1V0SIT1	Klosneuvirus	1.0e-37	26.9
WP_001280900.1\|20293_20509_+	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
WP_000256279.1\|20508_21381_+	polyprenyl synthetase family protein	NA	NA	NA	NA
WP_001041040.1\|21373_22201_+	TlyA family rRNA (cytidine-2'-O)-methyltransferase	NA	NA	NA	NA
WP_000747940.1\|22187_22661_+	ArgR family transcriptional regulator	NA	NA	NA	NA
WP_000923619.1\|22672_24331_+	DNA repair protein RecN	NA	NA	NA	NA
WP_000034838.1\|24443_25280_+	DegV family protein	A0A0N9SI50	Staphylococcus_phage	3.7e-14	38.0
WP_001035227.1\|25272_26112_+	SGNH/GDSL hydrolase family protein	NA	NA	NA	NA
WP_000806954.1\|26086_26689_+	YpmS family protein	NA	NA	NA	NA
WP_001284634.1\|26791_27067_+	HU family DNA-binding protein	A7KV42	Bacillus_phage	1.2e-25	71.9
WP_000269473.1\|27154_28297_-\|integrase	site-specific integrase	A1EAB7	Streptococcus_phage	4.8e-182	81.8
WP_000353930.1\|28411_28963_-	hypothetical protein	A7J267	Streptococcus_phage	1.7e-60	64.3
WP_000151182.1\|28980_29367_-	ImmA/IrrE family metallo-endopeptidase	A0A1S5SFH2	Streptococcus_phage	2.3e-35	57.6
WP_000484457.1\|29370_29718_-	helix-turn-helix transcriptional regulator	A0A126GGQ7	Streptococcus_phage	1.3e-42	76.1
WP_000739596.1\|30013_30259_+	hypothetical protein	X2L066	Streptococcus_phage	7.4e-08	55.8
WP_000092750.1\|30209_30998_-	hypothetical protein	NA	NA	NA	NA
WP_001112862.1\|31048_31240_+	hypothetical protein	A0A141DZR9	Streptococcus_phage	4.7e-18	69.8
WP_001123482.1\|31319_31631_+	hypothetical protein	M1Q0Y6	Streptococcus_phage	2.9e-49	87.3
31527:31542	attR	NA	NA	NA	NA
WP_000910901.1\|31778_32006_+	hypothetical protein	NA	NA	NA	NA
WP_000573547.1\|31998_32229_+	hypothetical protein	NA	NA	NA	NA
WP_000156424.1\|32212_33532_+	AAA family ATPase	A0A097BY67	Enterococcus_phage	3.1e-132	57.1
WP_001167564.1\|33546_34620_+	ATP-binding protein	A0A0K2CZH1	Paenibacillus_phage	9.6e-100	54.2
WP_000141563.1\|34715_35321_+	hypothetical protein	A0A097BY29	Enterococcus_phage	2.5e-36	48.2
WP_001870729.1\|35320_35929_+	hypothetical protein	D2XPY9	Bacillus_virus	7.2e-44	45.5
WP_032456395.1\|35934_37518_+	DEAD/DEAH box helicase family protein	A0A097BY72	Enterococcus_phage	1.7e-233	77.8
WP_000427885.1\|37526_37724_+	hypothetical protein	NA	NA	NA	NA
WP_001114109.1\|37716_37968_-	hypothetical protein	A0A097BY83	Enterococcus_phage	1.3e-20	52.8
WP_000829572.1\|38038_40318_+	AAA family ATPase	Q5YA88	Bacillus_phage	1.0e-276	63.1
WP_000666343.1\|40687_40921_+	hypothetical protein	A0A1S5SEA6	Streptococcus_phage	4.6e-15	60.3
WP_000151204.1\|40910_41309_+	RusA family crossover junction endodeoxyribonuclease	Q5YA86	Bacillus_phage	1.7e-41	61.2
WP_000687319.1\|41305_41521_+	hypothetical protein	NA	NA	NA	NA
WP_000145465.1\|41517_41754_+	DUF3310 domain-containing protein	A0A097PAQ7	Streptococcus_pyogenes_phage	2.3e-38	93.6
WP_001005355.1\|41750_41981_+	hypothetical protein	J7KK64	Streptococcus_phage	3.1e-32	100.0
WP_000052301.1\|41983_42295_+	hypothetical protein	J7KDM7	Streptococcus_phage	4.1e-27	55.8
WP_000667187.1\|42455_42956_+	DUF1642 domain-containing protein	J7KK91	Streptococcus_phage	7.3e-26	45.4
WP_000041038.1\|42952_43366_+	transcriptional regulator	A7J289	Streptococcus_phage	1.2e-42	60.6
WP_000041103.1\|43486_43918_+\|terminase	terminase small subunit	A7J290	Streptococcus_phage	3.9e-68	93.7
WP_000208745.1\|43907_45188_+\|terminase	PBSX family phage terminase large subunit	A7J291	Streptococcus_phage	1.3e-233	94.1
WP_000462948.1\|45202_46732_+\|portal	phage portal protein	A7J292	Streptococcus_phage	6.7e-248	83.8
WP_000358743.1\|46697_48140_+	hypothetical protein	A7J293	Streptococcus_phage	4.9e-224	77.5
WP_025194292.1\|48167_48356_+	hypothetical protein	A7J294	Streptococcus_phage	3.7e-15	77.4
WP_001042286.1\|48360_48564_+	hypothetical protein	A0A097PAR8	Streptococcus_pyogenes_phage	1.3e-13	53.4
WP_000797011.1\|48706_49276_+	DUF4355 domain-containing protein	A7J296	Streptococcus_phage	1.5e-72	89.9
WP_115357008.1\|50066_50144_-	hypothetical protein	NA	NA	NA	NA
WP_000356705.1\|50196_50553_+\|head,tail	phage head-tail connector protein	A7J298	Streptococcus_phage	6.7e-34	62.7
WP_000639437.1\|50563_50842_+	hypothetical protein	A7J299	Streptococcus_phage	4.2e-47	98.9
WP_000060408.1\|50838_51183_+	hypothetical protein	A7J2A0	Streptococcus_phage	6.9e-52	93.0
WP_000640604.1\|51186_51546_+	hypothetical protein	A7J2A1	Streptococcus_phage	5.6e-44	74.6
WP_000450517.1\|51557_52190_+\|tail	phage major tail protein, TP901-1 family	A7J2A2	Streptococcus_phage	2.6e-60	68.6
WP_000424190.1\|52240_52696_+	hypothetical protein	A7J2A3	Streptococcus_phage	3.1e-55	70.9
WP_000398752.1\|52770_53001_+	hypothetical protein	A7J2A4	Streptococcus_phage	2.2e-14	59.2
WP_000929195.1\|53029_57256_+	tape measure protein	A7J2A5	Streptococcus_phage	1.4e-21	46.6
WP_000365119.1\|57268_58111_+	hypothetical protein	A7J2A6	Streptococcus_phage	3.4e-76	48.6
WP_000206522.1\|58123_61951_+	hypothetical protein	A7J2A7	Streptococcus_phage	2.9e-162	49.2
WP_001873936.1\|62122_62539_+	DUF1366 domain-containing protein	NA	NA	NA	NA
WP_000564987.1\|62772_63069_+	hypothetical protein	Q938J6	Temperate_phage	1.2e-39	84.7
WP_001001965.1\|63070_63406_+\|holin	phage holin	A0A1P8VVK6	Streptococcus_phage	1.0e-36	72.1
WP_000236382.1\|63407_64127_+	CHAP domain-containing protein	A0A1U9WRD0	Streptococcus_virus	7.2e-59	70.3
WP_001061853.1\|64322_65219_+	sensor histidine kinase	J7KDG8	Streptococcus_phage	1.8e-168	100.0
WP_000258211.1\|65212_65512_+	STAS-like domain-containing protein	J7KJ12	Streptococcus_phage	3.8e-46	100.0
WP_000076712.1\|65621_65822_+	CsbD family protein	J7KJ36	Streptococcus_phage	2.9e-26	100.0
WP_000356856.1\|65862_66033_-	hypothetical protein	A0A286QNA2	Streptococcus_phage	1.1e-07	63.8
WP_000965650.1\|66452_66596_+	hypothetical protein	J7KIW4	Streptococcus_phage	3.6e-18	93.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_ALTB01000023

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_ALTB01000023_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_ALTB01000023_1

8208-8621

Orphan

Consensus_repeat	Method
GCCAGACGTTAANCCAGA	CRT

9 spacers

The CRISPR arrays of NZ_ALTB01000023_1

>merge|NZ_ALTB01000023|1|8208-8621|CRT
ACCAGACGTTAAGCCAGAAGCCAAACCAGAGGCCAAACCAGACGTTAAGCCAGAGGCCAAACCAGACGTTAAGCCAGAAGCTAAGCCAGACGTTAAACCAGAAGCTAAGCCAGACGTTAAACCAGAAGCTAAGCCAGACGTTAAACCAAAGGCCAAACCAGACGTTAAGCCAGAAGCTAAGCCAGACGTTAAACCAGACGTTAAACCAGACGTTAAGCCAGAGGCCAAACCAGAGGATAAGCCAGACGTTAAACCAGACGTTAAGCCAGAAGCTAAACCAGACGTTAAGCCAGAGGCCAAACCAGAAGCTAAGCCAGAAGCTAAGCCAGAAGCTAAGCCAGAGGCTAAGCCAGAAGCTAAACCAGAGGCTAAGTCAGAAGCTAAACCAGAGGCTAAGCTAGAAGCTAAACCAGA

>NZ_ALTB01000023|1|1|8208-8621|CRT
ACCAGACGTTAAGCCAGA	AGCCAAACCAGAGGCCAA
ACCAGACGTTAAGCCAGA	GGCCAAACCAGACGTTAAGCCAGAAGCTAA
GCCAGACGTTAAACCAGA	AGCTAAGCCAGACGTTAAACCAGAAGCTAA
GCCAGACGTTAAACCAAA	GGCCAAACCAGACGTTAAGCCAGAAGCTAA
GCCAGACGTTAAACCAGA	CGTTAAACCAGACGTTAAGCCAGAGGCCAAACCAGAGGATAA
GCCAGACGTTAAACCAGA	CGTTAAGCCAGAAGCTAA
ACCAGACGTTAAGCCAGA	GGCCAAACCAGAAGCTAA
GCCAGAAGCTAAGCCAGA	AGCTAAGCCAGAGGCTAA
GCCAGAAGCTAAACCAGA	GGCTAAGTCAGAAGCTAAACCAGAGGCTAA
GCTAGAAGCTAAACCAGA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_ALTB01000023.1\|WP_000409544.1\|9608_10814_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133037
NZ_ALTB01000023.1\|WP_000145178.1\|14791_17293_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
NZ_ALTB01000023.1\|WP_000953624.1\|12279_13125_+\|patatin-family-protein	unknown	unknown	gnl\|CDD\|132847
NZ_ALTB01000023.1\|WP_000161338.1\|19465_20152_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_ALTB01000023.1\|WP_001093389.1\|20384_25097_-\|S8-family-serine-peptidase	unknown	unknown	gnl\|CDD\|173801
NZ_ALTB01000023.1\|WP_000074744.1\|13167_14415_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340929
NZ_ALTB01000023.1\|WP_000764803.1\|3965_6287_+\|penicillin-binding-protein	unknown	unknown	gnl\|CDD\|223815
NZ_ALTB01000023.1\|WP_000497678.1\|6523_6697_+\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|223762
NZ_ALTB01000023.1\|WP_000459236.1\|1372_3013_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226987
NZ_ALTB01000023.1\|WP_000222146.1\|10878_12075_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133037
NZ_ALTB01000023.1\|WP_000730417.1\|18080_19469_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_ALTB01000023.1\|WP_000010476.1\|3037_3922_-\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
NZ_ALTB01000023.1\|WP_000385649.1\|0_1203_+\|phosphopentomutase	unknown	unknown	gnl\|CDD\|235430
NZ_ALTB01000023.1\|WP_000057521.1\|6335_6488_+\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_ALTB01000023.1\|WP_000887149.1\|9022_9562_+\|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_ALTB01000023.1\|WP_000903268.1\|17379_17988_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_ALTB01000023.1\|WP_000409544.1\|9608_10814_-\|hypothetical-protein	gnl\|CDD\|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	1.96805e-72
NZ_ALTB01000023.1\|WP_000145178.1\|14791_17293_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
NZ_ALTB01000023.1\|WP_000953624.1\|12279_13125_+\|patatin-family-protein	gnl\|CDD\|132847	cd07208, Pat_hypo_Ecoli_yjju_like, Hypothetical patatin similar to yjju protein of Escherichia coli. Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.	3.0357e-122
NZ_ALTB01000023.1\|WP_000161338.1\|19465_20152_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.15526e-62
NZ_ALTB01000023.1\|WP_001093389.1\|20384_25097_-\|S8-family-serine-peptidase	gnl\|CDD\|173801	cd07475, Peptidases_S8_C5a_Peptidase, Peptidase S8 family domain in Streptococcal C5a peptidases. Streptococcal C5a peptidase (SCP), is a highly specific protease and adhesin/invasin. The subtilisin-like protease domain is located at the N-terminus and contains a protease-associated domain inserted into a loop. There are three fibronectin type III (Fn) domains at the C-terminus. SCP binds to integrins with the help of Arg-Gly-Asp motifs which are thought to stabilize conformational changes required for substrate binding. Peptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	5.81799e-90
NZ_ALTB01000023.1\|WP_000074744.1\|13167_14415_-\|MFS-transporter	gnl\|CDD\|340929	cd17371, MFS_MucK, Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.13125e-70
NZ_ALTB01000023.1\|WP_000764803.1\|3965_6287_+\|penicillin-binding-protein	gnl\|CDD\|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	0
NZ_ALTB01000023.1\|WP_000497678.1\|6523_6697_+\|preprotein-translocase-subunit-SecE	gnl\|CDD\|223762	COG0690, SecE, Preprotein translocase subunit SecE [Intracellular trafficking and secretion].	5.81702e-09
NZ_ALTB01000023.1\|WP_000459236.1\|1372_3013_+\|hypothetical-protein	gnl\|CDD\|226987	COG4640, COG4640, Predicted membrane protein [Function unknown].	2.43912e-08
NZ_ALTB01000023.1\|WP_000222146.1\|10878_12075_-\|hypothetical-protein	gnl\|CDD\|133037	cd04194, GT8_A4GalT_like, A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.	4.07197e-67
NZ_ALTB01000023.1\|WP_000010476.1\|3037_3922_-\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	7.14066e-85
NZ_ALTB01000023.1\|WP_000385649.1\|0_1203_+\|phosphopentomutase	gnl\|CDD\|235430	PRK05362, PRK05362, phosphopentomutase; Provisional.	0
NZ_ALTB01000023.1\|WP_000057521.1\|6335_6488_+\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	2.53308e-18
NZ_ALTB01000023.1\|WP_000887149.1\|9022_9562_+\|transcription-termination/antitermination-protein-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	3.00072e-83
NZ_ALTB01000023.1\|WP_000730417.1\|18080_19469_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	8.25321e-46

>NZ_ALTB01000023.1|WP_000497678.1|6523_6697_+|preprotein-translocase-subunit-SecE
MFVKGIFQVLRDTTWPNRKQRWKDFISILEYTVFFTIVIYIFDKLLAAGVMDLINRF
>NZ_ALTB01000023.1|WP_000057521.1|6335_6488_+|50S-ribosomal-protein-L33
MAQKKASLACTECGSRNYSIGVSSTPKPTRLEVNKFCKYCKKYTIHKETR
>NZ_ALTB01000023.1|WP_000764803.1|3965_6287_+|penicillin-binding-protein
MKLFDKFIDLFRVDEDNDEMTRKNEQETREETSNLDGEEVYDIDDITRPSKSQYQRGIRHQKENAKSRPEWLQKVDRYLPSPKNPIRRFWRRYRIGKLLFIALMAFILIFGSYLFYLSKTATVSDLQSALKTTTTIYDKNKEYAGKLSGQKGTYVELNAISDHLKNAVIATEDRTFYENNGVNFKRFFLAVATLGKFGGGSTITQQLAKNAYLSQDQTIKRKAREFFLALELTKKYSKAEILTMYLNNSYFGNGVWGVEDASRKYFGTSAANLTVDEAATLAGMLKGPEVYNPYYSVENATNRRDTVLAAMVDAGKLTKSQAKEAASIGMKNRLADTYAGKINDYRYPSYFDAVVNEAIDTYGISEKDIVNNGYKIYTALDQNYQSGMQKTFDDTSLFPVSDYDGQSAQGASVALDPKTGGVRGLVGRVQSTKDAQFRSFNYATQSKRSPASTIKPLVVYSPAIASGWSIDKELPNKVQDFHGYKPSNYGGIETESIPMYQALANSYNIPAVYTLDKLGINKAFTYGRKFGLNMSSANKELGVALGGSVTTNPLEMAQAYSTFANDGIMHRAHLITRIETANGKLVKQFTDKPKRVISRSVASKMTSMMLGTFSNGTAINANVYGYTMAGKTGTTETDFNPNLSGDQWVVGYTPDVVISQWVGFKNTDKHHYLTDSSAGTASNIFSTQASYILPYTKGSSFTHIENAYFQNGIGSVYNAQDASNTTNQESRSIINDLKDSASKAAQDISRAVEDSNFQEKVKDAWNSLKDYFR
>NZ_ALTB01000023.1|WP_000010476.1|3037_3922_-|RluA-family-pseudouridine-synthase
MSFSLKIRNPYGEHTVKELLEDYFLIPRKIRHFLRVKKHVLINNEFINWQTVVQENDTITLIFDDEDYPTKKIPLGRAELIDCLYEDEHLIIVNKPEGMKTHGNQPNEIALLNHVSAYSGQTCYVVHRLDMETSGAVLFAKNPFILPLINQRLERKEIWREYWALVEGKFSPKHQVLRDKIGRNRHDRRKRIIDSKNGQHAMTIIDVLKYIQNSSLIKCRLETGRTHQIRVHLSHHGHPLIGDPLYNPSSNNERLMLHAHRLTLSHPLTCETISVEAPSSTFEKILNNYKKGVG
>NZ_ALTB01000023.1|WP_000459236.1|1372_3013_+|hypothetical-protein
MFDFFKKKVVKVCLVIFGIVLVSLLSLGFFYFSKGQVLSRFVAARSRTSGQAFDNIKEYMVWSDTGESITNDEANYANFEPLSKSEARKLGQEIKEGNKNDSMYLKRVGSRLGIFPDYRIANKPMSLTLKTNVPKLDVLLNQKKVATSNSDHFSVTVERLPRTHYTASLEGTSDGKEIKLKKDYDGKNQTIDLSVAFKSFTVTSNLMDGNLYFGDNRIAKLKDGSHSVENYPVTDGSKAYIKKVFNDGEITSHKQKLISIADNQTIKLDVDGLLNEKEAGQKLITAFNQLILYVSTGQDPQTLGTVFEKGAENDFYKGLKESIKAKFVTDNRKASHFTIPNIVLNKMTQVGKESYQVNFAADYDFNYDKSTDPDKKTYGHIIQNLTGNFIMKKSGNSYLISNDGKKDITVAKETNKVKADPVSIFPENLVGSWKGEVEDGTVTMTFDKDGKVTQKKVYKDSKSKESNHSAKVTKLEDKGNGLYLYQYESGTDTTTFVTGGIGGLKVKYAYGIKIEGNKIIPVIWQTSSDGEFDYHKPLLSKPLTKQ
>NZ_ALTB01000023.1|WP_000385649.1|0_1203_+|phosphopentomutase
FDRIHLVVLDSVGIGAAPDANDFVNAGVPDGASDTLGHISKTVGLAVPNMAKIGLGNIPRPQALKTVPAEENPSGYATKLQEVSLGKDTMTGHWEIMGLNITEPFDTFWNGFPEDIITKIEDFSGRKVIREANKPYSGTAVIDDFGPRQMETGELIIYTSADPVLQIAAHEDIIPLEELYRICEYARSITMERPALLGRIIARPYVGEPGNFTRTANRHDYAVSPFEDTVLNKLDQAGIDTYAVGKINDIFNGSGINHDMGHNKSNSHGIDTLIKTMGLSEFEKGFSFTNLVDFDALYGHRRDPHGYRDCLHEFDERLPEIISAMRDKDLLLITADHGNDPTYAGTDHTREYIPLLAYSPSFTGNGLIPVGHFADISATVADNFGVDTAMIGESFLQDLV
>NZ_ALTB01000023.1|WP_000887149.1|9022_9562_+|transcription-termination/antitermination-protein-NusG
MLDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLDNILRVEIPTQTVNVEKNGKTKEIEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPTPLLEEEIRSILISMGQTVDVFDTNIKEGDVVQIIDGAFIGQEGRVVEIENNKVKLMINMFGSETQAELELYQVAEL
>NZ_ALTB01000023.1|WP_000409544.1|9608_10814_-|hypothetical-protein
MEKAVALAVDSNYLDKALVTIKSICVYNRNITFYLFNQDTPVEWVRNINRKLEPLGSKLINVKIYNYDIAHLTTFLTVSTWFRLFLADYIPSSRVLYLDSDIIVNTNLDYLFELDFKGYYLAAVKDPHKNEEGGFNAGMLLANLELWREDGLTKTLLKTAEELHRVVKTGDQSILNIVCHNRWLSLNKTWNFQTYDVVSRYNHRSYLYLNIENRTPNIIHFLTSDKPWNENSVARFRELWWYYFQLDFCQLTGKQRKVISYEKSMELLSVSDIHLFTLTSSDNLEHIESLICRCPTVQFHIGAYTTVSNKLSKLEQYPNVLVYPELIEARIEKLITLATAYLDINHGPEVGNILQRVHLKQKPIYSFNNTSHQENITKHIVNHNSIDNMVVLINELNLNQL
>NZ_ALTB01000023.1|WP_000222146.1|10878_12075_-|hypothetical-protein
MTYQKTVVLAGDYSYIRQIETTLKSLCVYHENLSIFIFNQDIPQEWFLAMKDRVGQTGNQIQDVKLFHDHLSPKWENKKLNHINYMTYARYFIPQYISADTVLYLDSDLVVTTNLDNLFQISLDNAYLAAVPALFGLGYGFNAGVMVINNQRWRQENMTIKLIEKNQKEIENANEGDQTILNRMFENQVIYLDDTYNFQIGFDMGAAIDGHKFIFDIPITPLPKIIHYISGIKPWQTLSNMRLREVWWHYNLLEWSSIISSKKVFGLDHPIKTQNYRLNFLIVTTSDCIPSISELVTALPDCLFHIAAPTVMSDILISLLAFENIRLHKTYTPPIIDKLLAEADIYLDINVFGKMEGILQKMSQSEKPILTTRECNSQLVPETVFASIDDLINYLQSI
>NZ_ALTB01000023.1|WP_000953624.1|12279_13125_+|patatin-family-protein
MLSVGLVLEGGGMRGLYTAGVLDAFLDAGIKIDGIVSVSAGALFGVNFVSRQRERALRYNKKYLSHPKYMSLRSWFRTGNFVNKDFTYYEVPMKLDVFDDEAFKKSSIDFYVVATEMTSGKPEYFKIDSVFEQMEILRASSALPVVSKMVDWQGKKYLDGGLSDSIPVDFARGLGFDKLIVVMTRPLNYQKKPSSGRLYKTLYRKYPNFVKTASNRYQQYNNSLEKVMSLEKTGDLFAIRPSKSLVIGRLEKNPDKLDSIYQLGMKDAKSVMPELNSYLMK
>NZ_ALTB01000023.1|WP_000074744.1|13167_14415_-|MFS-transporter
MSPLNINKNNWRALIAAIVASGTDDLNIMFLAFSMSTIITDLHLSAAQAGWIGTITNLGMLVGGLIFGLLADRYNKFKVFKWTILIFSIATGLVFFTTNLSYLYIMRFIAGIGVGGEYGIAIAIMAGIVPTNKMGRISSLNGIAGQVGSISSALLAGWLAPALGWRGLFLFGLLPIVLVLWMQFAVDDKDILDQYNTDADDEPLDISIKALFDTPVLATQSLALMVMTTVQIAGYFGMMNWLPTIIQTNLNVSVKNSSLWMIATILGMCLGMLVFGQLLDKFGPRLVYGCFLLSSAICVYLFQFATTMPSMIIGGAVVGFFVNGMFAGYGAMITRLYPHHIRSTANNLILNVGRAIGGFSSVIIGMILDVSNVSMVMLFLASLYIVSFLSMLSIKQLKRQKYHTNLTQLDVKPTD
>NZ_ALTB01000023.1|WP_000145178.1|14791_17293_+|leucine--tRNA-ligase
MTFYNHKEIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTDKDFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQAEAVAEYKRQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFNLDIIPVLEGGNVEEAAFTEDGLHINSDFLDGLDKAAAIAKMVEWLEAEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITEENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDKLFSDYAKGFVQLIAPFAPHLGEELWQVLTASGQSISYVPWPSYDESKLVENEIEIVVQIKGKVKAKLVVAKDLSREELQDLALANEKVQAEIAGKDIIKVIAVPNKLVNIVVK
>NZ_ALTB01000023.1|WP_000903268.1|17379_17988_-|hypothetical-protein
MLHSKKIHSLSLIAVLSLATYTSLQPNHVTAEQSQKTSTVHMSQKTIEHKLKVADKEAAPLYAKIDHIQRHIEVKKAKDLKVIELYINKDINQLEKQNKRLLTKFYTSIDNQTWDSTSEVKKLIDKTNLSTNEKDRLKLYFEQRAYLETRLNDRYQKFDNSIENQNKELKILTSKIEKIYQKHGITKEVLKTYYAKKTVRAD
>NZ_ALTB01000023.1|WP_000730417.1|18080_19469_-|HAMP-domain-containing-histidine-kinase
MKKKSLISNLILINSITLFLGFYLIYFSVNYVIKDYVHQMTRNSMQANFTILDSIYNNKKIPDENMVNQDSIFVWSYYAIFDQHYRMKYGTDNHKKESHDIIRYLTQKRLWQISKEKDGMFVTIKKKTYYVMTKDYSGILVDGSIKKVPKAQSQLFHVINFSDITYTQHLITKINHFLIVILVLTYIPMLFIMRKTFTGIRESIQSVQTYISSLWKNQGNHQSSQKEIVFSDFDPLLLESQEMANRIYQAEESQRNFFQNASHELRTPLMSIQGYTEGVQEGIIDAELAHSVILQESKKMKQLVDDIILLSKLDSNLSDQKDEFSLNELLNSIIAYFKPLANKQKISITYRPDKHEKLLKGNEELIQRAINNILSNALRYAVSHIEISYTNQKLTISNDGPAISKEDLPYIFDRFYKGHGGQTGIGLAMTKEIIKQHHGNIIAESDSTSTTFTIYFNCHKIA
>NZ_ALTB01000023.1|WP_000161338.1|19465_20152_-|response-regulator-transcription-factor
MTKIIYFADDEKNIRDLVVPFLEHDGFTVRAFETGDLLLEAYKNQKPDLVILDIMMPGTNGLDVMKSIRQYDNIPIIMLTARDSDVDFITAFNLGTDDYFTKPFSPIKLSLHVKALFKRLDEKAIKNDTQYQFLDLTLDTEKRIALLSNEEMPLTKTEFDFLLVLIEKPETAFSRETLLNRIWGFDDIESRAVDDTIKRLRKKFKQYHSQVSIKTVWGYGFKLIKEDK
>NZ_ALTB01000023.1|WP_001093389.1|20384_25097_-|S8-family-serine-peptidase
MNTKQRFSIRKYKLGAVSVLLGTLFFLGGITNVAADSVINKPSDIAVEQQVKDSPTSIANETPTNNTSSALASTAQDNLVTKANNSPTETQPVAESHSQATETFSPVANQPVESTQEVSKTPLTKQNLAVKSTPAISKETPQNIDSNKIITVPKVWNTGYKGEGTVVAIIDSGLDINHDALQLNDSTKAKYQNEQQMNAAKAKAGINYGKWYNNKVIFGHNYVDVNTELKEVKSTSHGMHVTSIATANPSKKDTNELIYGVAPEAQVMFMRVFSDEKRGTGPALYVKAIEDAVKLGADSINLSLGGANGSLVNADDRLIKALEMARLAGVSVVIAAGNDGTFGSGASKPSALYPDYGLVGSPSTAREAISVASYNNTTLVNKVFNIIGLENNRNLNNGLAAYADPKVSDKTFEVGKQYDYVFVGKGNDNDYKDKTLNGKIALIERGDITFTKKVVNAINHGAVGAIIFNNKAGEANLTMSLDPEASAIPAIFTQKEFGDVLAKNNYKIVFNNIKNKQANPNAGVLSDFSSWGLTADGQLKPDLSAPGGSIYAAINDNEYDMMSGTSMASPHVAGATALVKQYLLKEHPELKKGDIERTVKYLLMSTAKAHLNKDTGAYTSPRQQGAGIIDVAAAVQTGLYLTGGENNYGSVTLGNIKDKISFDVTVHNINKVAKDLHYTTYLNTDQVKDGFVTLAPQQLGTFTGKTIRIEPGQTQTITIDIDVSKYHDMLKKVMPNGYFLEGYVRFTDPVDGGEVLSIPYVGFKGEFQNLEVLEKSIYKLVANKEKGFYFQPKQTNEVPGSEDYTALMTTSSEPIYSTDGTSPIQLKALGSYKSIDGKWILQLDQKGQPHLAISPNDDQNQDAVAVKGVFLRNFNNLRAKVYRADDVNLQKPLWVSAPQAGDKNYYSGNTENPKSTFLYDTEWKGTTTDGIPLEDGKYKYVLTYYSDVPGSKPQQMVFDITLDRQAPTLTTATYDKDRRIFKARPAVEHGESGIFREQVFYLKKDKDGHYNSVLRQQGEDGILVEDNKVFIKQEKDGSFILPKEVNDFSHVYYTVEDYAGNLVSAKLEDLINIGNKNGLVNVKVFSPELNSNVDIDFSYSVKDDKGNIIKKQHHGKDLNLLKLPFGTYTFDLFLYDEERANLISPKSVTVTISEKDSLKDVLFKVNLLKKAALLVEFDKLLPKGATVQLVTKTNTVVDLPKATYSPTDYGKNIPVGDYRLNVTLPSGYSTLENLDDLLVSVKEDQVNLTKLTLINKAPLINALAEQTDIITQPVFYNAGTHLKNNYLANLEKAQTLIKNRVEQTSIDNAIAALRESRQALNGKETDTSLLAKAILAETEIKGNYQFVNASPLSQSTYINQVQLAKNLLQKPNVTQSEVDKALENLDIAKNQLNGHETDYSGLHHMIIKANVLKQTSSKYQNASQFAKENYNNLIKKAELLLSNRQATQAQVEELLNQIKATEQELDGRDRVSSAENYSQSLNDNDSLNTTPINPPNQPQALIFKKGMTKESEVAQKRVLGVTSQTDNQKVKTNKLPKTGESTPKITYTILLFSLSMLGLATIKLKSIKRE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_ALTB01000023_1	1.1\|8226\|18\|NZ_ALTB01000023\|CRT	8226-8243	18	NZ_ALTB01000023.1	8610-8627	1	0.944
NZ_ALTB01000023_1	1.8\|8538\|18\|NZ_ALTB01000023\|CRT	8538-8555	18	NZ_ALTB01000023.1	8610-8627	2	0.889

1. spacer 1.1|8226|18|NZ_ALTB01000023|CRT matches to position: 8610-8627, mismatch: 1, identity: 0.944

agccaaaccagaggccaa	CRISPR spacer
agctaaaccagaggccaa	Protospacer
***.**************

2. spacer 1.8|8538|18|NZ_ALTB01000023|CRT matches to position: 8610-8627, mismatch: 2, identity: 0.889

agctaagccagaggctaa	CRISPR spacer
agctaaaccagaggccaa	Protospacer
******.********.**

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	KC206276	Escherichia phage EC1-UPM, complete genome	22907-22936	5	0.833
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	NC_019423	Enterobacter phage IME11, complete genome	38504-38533	5	0.833
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	MN855733	Siphoviridae sp. isolate 355, complete genome	42082-42111	5	0.833
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	KF562340	Escherichia phage vB_EcoP_PhAPEC7, complete genome	23106-23135	5	0.833
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	MH733496	Escherichia phage PGN829.1, complete genome	71462-71491	5	0.833
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	KF192075	Escherichia phage vB_EcoP_PhAPEC5, complete genome	22744-22773	5	0.833
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	MH358458	Escherichia phage phi G17, complete genome	37666-37695	5	0.833
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	MG208881	Escherichia phage St11Ph5, complete genome	24690-24719	5	0.833
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	HQ259105	Escherichia phage vB_EcoP_G7C, complete genome	23924-23953	5	0.833
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	KF620435	Shigella phage pSb-1, complete genome	48997-49026	5	0.833
NZ_ALTB01000023_1	1.2\|8262\|30\|NZ_ALTB01000023\|CRT	8262-8291	30	LC553736	Salmonella phage SAP012 DNA, complete sequence	29488-29517	6	0.8
NZ_ALTB01000023_1	1.4\|8358\|30\|NZ_ALTB01000023\|CRT	8358-8387	30	LC553736	Salmonella phage SAP012 DNA, complete sequence	29488-29517	6	0.8
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	MN693170	Marine virus AFVG_25M480, complete genome	14203-14232	7	0.767
NZ_ALTB01000023_1	1.2\|8262\|30\|NZ_ALTB01000023\|CRT	8262-8291	30	NC_019401	Cronobacter phage vB_CsaM_GAP32, complete genome	16599-16628	8	0.733
NZ_ALTB01000023_1	1.4\|8358\|30\|NZ_ALTB01000023\|CRT	8358-8387	30	NC_019401	Cronobacter phage vB_CsaM_GAP32, complete genome	16599-16628	8	0.733
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	MH341452	Listeria phage PSU-VKH-LP040, complete genome	30946-30975	8	0.733
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	KP399677	Listeria phage vB_LmoS_188, complete genome	30280-30309	8	0.733
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	KP399678	Listeria phage vB_LmoS_293, complete genome	31517-31546	8	0.733
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	DQ003642	Listeria phage A006, complete genome	29765-29794	8	0.733
NZ_ALTB01000023_1	1.9\|8574\|30\|NZ_ALTB01000023\|CRT	8574-8603	30	MH616814	Microviridae sp. isolate ctjj954, complete genome	2232-2261	8	0.733

1. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to KC206276 (Escherichia phage EC1-UPM, complete genome) position: , mismatch: 5, identity: 0.833

---ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
actgactaa---agaagctaaagcagaggctaa	Protospacer
   *.****   ********** **********

2. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to NC_019423 (Enterobacter phage IME11, complete genome) position: , mismatch: 5, identity: 0.833

---ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
actgactaa---agaagctaaagcagaggctaa	Protospacer
   *.****   ********** **********

3. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to MN855733 (Siphoviridae sp. isolate 355, complete genome) position: , mismatch: 5, identity: 0.833

---ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
attgactaa---agaagctaaagcagaggctaa	Protospacer
   *.****   ********** **********

4. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to KF562340 (Escherichia phage vB_EcoP_PhAPEC7, complete genome) position: , mismatch: 5, identity: 0.833

---ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
actgactaa---agaagctaaagcagaggctaa	Protospacer
   *.****   ********** **********

5. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to MH733496 (Escherichia phage PGN829.1, complete genome) position: , mismatch: 5, identity: 0.833

---ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
actgactaa---agaagctaaagcagaggctaa	Protospacer
   *.****   ********** **********

6. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to KF192075 (Escherichia phage vB_EcoP_PhAPEC5, complete genome) position: , mismatch: 5, identity: 0.833

---ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
actgactaa---agaagctaaagcagaggctaa	Protospacer
   *.****   ********** **********

7. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to MH358458 (Escherichia phage phi G17, complete genome) position: , mismatch: 5, identity: 0.833

---ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
actgactaa---agaagctaaagcagaggctaa	Protospacer
   *.****   ********** **********

8. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to MG208881 (Escherichia phage St11Ph5, complete genome) position: , mismatch: 5, identity: 0.833

---ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
actgactaa---agaagctaaagcagaggctaa	Protospacer
   *.****   ********** **********

9. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to HQ259105 (Escherichia phage vB_EcoP_G7C, complete genome) position: , mismatch: 5, identity: 0.833

---ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
actgactaa---agaagctaaagcagaggctaa	Protospacer
   *.****   ********** **********

10. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to KF620435 (Shigella phage pSb-1, complete genome) position: , mismatch: 5, identity: 0.833

---ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
actgactaa---agaagctaaagcagaggctaa	Protospacer
   *.****   ********** **********

11. spacer 1.2|8262|30|NZ_ALTB01000023|CRT matches to LC553736 (Salmonella phage SAP012 DNA, complete sequence) position: , mismatch: 6, identity: 0.8

ggccaaaccagacgttaagccagaagctaa	CRISPR spacer
agtccaaccagacgatcagccagaagctga	Protospacer
.*.* ********* * ***********.*

12. spacer 1.4|8358|30|NZ_ALTB01000023|CRT matches to LC553736 (Salmonella phage SAP012 DNA, complete sequence) position: , mismatch: 6, identity: 0.8

ggccaaaccagacgttaagccagaagctaa	CRISPR spacer
agtccaaccagacgatcagccagaagctga	Protospacer
.*.* ********* * ***********.*

13. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to MN693170 (Marine virus AFVG_25M480, complete genome) position: , mismatch: 7, identity: 0.767

ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
tgctaagtaaaaagctaaaccagataccat	Protospacer
 ******* *.************* .*.*

14. spacer 1.2|8262|30|NZ_ALTB01000023|CRT matches to NC_019401 (Cronobacter phage vB_CsaM_GAP32, complete genome) position: , mismatch: 8, identity: 0.733

ggccaaaccagacgttaagccagaagctaa	CRISPR spacer
accagaaccagaagttaagccagaacctgc	Protospacer
. * .******* ************ **.

15. spacer 1.4|8358|30|NZ_ALTB01000023|CRT matches to NC_019401 (Cronobacter phage vB_CsaM_GAP32, complete genome) position: , mismatch: 8, identity: 0.733

ggccaaaccagacgttaagccagaagctaa	CRISPR spacer
accagaaccagaagttaagccagaacctgc	Protospacer
. * .******* ************ **.

16. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to MH341452 (Listeria phage PSU-VKH-LP040, complete genome) position: , mismatch: 8, identity: 0.733

ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
tgctaagtcagaagctaaacaagttatttt	Protospacer
 ******************* **  ..*

17. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to KP399677 (Listeria phage vB_LmoS_188, complete genome) position: , mismatch: 8, identity: 0.733

ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
tgctaagtcagaagctaaacaagttatttt	Protospacer
 ******************* **  ..*

18. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to KP399678 (Listeria phage vB_LmoS_293, complete genome) position: , mismatch: 8, identity: 0.733

ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
tgctaagtcagaagctaaacaagttatttt	Protospacer
 ******************* **  ..*

19. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to DQ003642 (Listeria phage A006, complete genome) position: , mismatch: 8, identity: 0.733

ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
tgctaagtcagaagctaaacaagttatttt	Protospacer
 ******************* **  ..*

20. spacer 1.9|8574|30|NZ_ALTB01000023|CRT matches to MH616814 (Microviridae sp. isolate ctjj954, complete genome) position: , mismatch: 8, identity: 0.733

ggctaagtcagaagctaaaccagaggctaa	CRISPR spacer
gagcagaccagaagcaaaaccagaggctat	Protospacer
*. .*...******* *************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_ALTB01000029

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_ALTB01000029_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_ALTB01000029_1

22102-22193

Orphan

Consensus_repeat	Method
GATGCCGGATTTGTCTACTCTCGTGGGTATGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_ALTB01000029_1

>merge|NZ_ALTB01000029|1|22102-22193|CRISPRCasFinder
GATGCCGGATTTGTCTACTCTCGTGGGTATGCGCCTTCTGAATCAAGCTATCCTTCACGCGATGCCGGATTTATCTACTCTCGTGGGTATGC

>NZ_ALTB01000029|1|1|22102-22193|CRISPRCasFinder
GATGCCGGATTTGTCTACTCTCGTGGGTATGC	GCCTTCTGAATCAAGCTATCCTTCACGC
GATGCCGGATTTATCTACTCTCGTGGGTATGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_ALTB01000029.1\|WP_001868429.1\|23834_25466_-\|DAK2-domain-containing-protein	unknown	unknown	gnl\|CDD\|274671
NZ_ALTB01000029.1\|WP_000425371.1\|15575_16331_-\|adaptor-protein-MecA	unknown	unknown	gnl\|CDD\|235030
NZ_ALTB01000029.1\|WP_000905327.1\|16450_17290_-\|undecaprenyl-diphosphate-phosphatase	unknown	unknown	gnl\|CDD\|234712
NZ_ALTB01000029.1\|WP_000052520.1\|22802_23687_-\|SPFH-domain-containing-protein	unknown	unknown	gnl\|CDD\|259805
NZ_ALTB01000029.1\|WP_000612108.1\|14413_15574_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
NZ_ALTB01000029.1\|WP_001218456.1\|10515_10959_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	unknown	unknown	gnl\|CDD\|273918
NZ_ALTB01000029.1\|WP_000216445.1\|25498_25864_-\|Asp23/Gls24-family-envelope-stress-response-protein	unknown	unknown	gnl\|CDD\|224221
NZ_ALTB01000029.1\|WP_000197060.1\|26422_27340_+\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|133427
NZ_ALTB01000029.1\|WP_001018987.1\|27423_28305_-\|fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|180926
NZ_ALTB01000029.1\|WP_000710515.1\|17335_19219_-\|DUF2207-domain-containing-protein	unknown	unknown	gnl\|CDD\|378333
NZ_ALTB01000029.1\|WP_000031280.1\|12179_13442_-\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
NZ_ALTB01000029.1\|WP_000514047.1\|29852_31043_-\|argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|234785
NZ_ALTB01000029.1\|WP_000722379.1\|19354_20905_+\|ABC-transporter-substrate-binding-protein/permease	unknown	unknown	gnl\|CDD\|270345
NZ_ALTB01000029.1\|WP_000164582.1\|28445_29834_-\|argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|179143
NZ_ALTB01000029.1\|WP_032457295.1\|31196_32267_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
NZ_ALTB01000029.1\|WP_000114502.1\|13478_14249_-\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
NZ_ALTB01000029.1\|WP_000173341.1\|10945_12178_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|131034
NZ_ALTB01000029.1\|WP_001140949.1\|25995_26184_-\|50S-ribosomal-protein-L28	unknown	unknown	gnl\|CDD\|234736
NZ_ALTB01000029.1\|WP_000189496.1\|20914_21655_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
NZ_ALTB01000029.1\|WP_000818733.1\|22594_22711_+\|putative-metal-homeostasis-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_ALTB01000029.1\|WP_001868429.1\|23834_25466_-\|DAK2-domain-containing-protein	gnl\|CDD\|274671	TIGR03599, YloV, DAK2 domain fusion protein YloV. This model describes a protein family that contains an N-terminal DAK2 domain (pfam02734), so named because of similarity to the dihydroxyacetone kinase family family. The GTP-binding protein CgtA (a member of the obg family) is a bacterial GTPase associated with ribosome biogenesis, and it has a characteristic extension (TIGR03595) in certain lineages. This protein family described here was found, by the method of partial phylognetic profiling, to have a phylogenetic distribution strongly correlated to that of TIGR03595. This correlation implies some form of functional coupling.	0
NZ_ALTB01000029.1\|WP_000425371.1\|15575_16331_-\|adaptor-protein-MecA	gnl\|CDD\|235030	PRK02315, PRK02315, adaptor protein MecA.	1.75436e-87
NZ_ALTB01000029.1\|WP_000905327.1\|16450_17290_-\|undecaprenyl-diphosphate-phosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	5.20123e-101
NZ_ALTB01000029.1\|WP_000052520.1\|22802_23687_-\|SPFH-domain-containing-protein	gnl\|CDD\|259805	cd03407, SPFH_like_u4, Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.	2.78758e-128
NZ_ALTB01000029.1\|WP_000612108.1\|14413_15574_-\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	1.7754e-73
NZ_ALTB01000029.1\|WP_001218456.1\|10515_10959_-\|SUF-system-NifU-family-Fe-S-cluster-assembly-protein	gnl\|CDD\|273918	TIGR01994, Iron-sulfur_cluster_assembly_scaffold_protein_IscU, SUF system FeS assembly protein, NifU family. Three iron-sulfur cluster assembly systems are known so far. ISC is broadly distributed while NIF tends to be associated with nitrogenase in nitrogen-fixing bacteria. The most recently described is SUF, believed to be important to maintain the function during aerobic stress of enzymes with labile Fe-S clusters. It is fairly widely distributed. This family represents one of two different proteins proposed to act as a scaffold on which the Fe-S cluster is built and from which it is transferred. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	1.98821e-70
NZ_ALTB01000029.1\|WP_000216445.1\|25498_25864_-\|Asp23/Gls24-family-envelope-stress-response-protein	gnl\|CDD\|224221	COG1302, COG1302, Uncharacterized protein conserved in bacteria [Function unknown].	4.6281e-36
NZ_ALTB01000029.1\|WP_000197060.1\|26422_27340_+\|L-lactate-dehydrogenase	gnl\|CDD\|133427	cd05291, HicDH_like, L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases. L-2-hydroxyisocapronate dehydrogenase (HicDH) catalyzes the conversion of a variety of 2-oxo carboxylic acids with medium-sized aliphatic or aromatic side chains. This subfamily is composed of HicDHs and some bacterial L-lactate dehydrogenases (LDH). LDHs catalyze the last step of glycolysis in which pyruvate is converted to L-lactate. Bacterial LDHs can be non-allosteric or may be activated by an allosteric effector such as fructose-1,6-bisphosphate. Members of this subfamily with known structures such as the HicDH of Lactobacillus confusus, the non-allosteric LDH of Lactobacillus pentosus, and the allosteric LDH of Bacillus stearothermophilus, show that they exist as homotetramers. The HicDH-like subfamily is part of the NAD(P)-binding Rossmann fold superfamily, which includes a wide variety of protein families including the NAD(P)-binding domains of alcohol dehydrogenases, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate dehydrogenases, formate/glycerate dehydrogenases, siroheme synthases, 6-phosphogluconate dehydrogenases, aminoacid dehydrogenases, repressor rex, and NAD-binding potassium channel domains, among others.	2.38551e-147
NZ_ALTB01000029.1\|WP_001018987.1\|27423_28305_-\|fructose-bisphosphate-aldolase	gnl\|CDD\|180926	PRK07315, PRK07315, fructose-bisphosphate aldolase; Provisional.	0
NZ_ALTB01000029.1\|WP_000710515.1\|17335_19219_-\|DUF2207-domain-containing-protein	gnl\|CDD\|378333	pfam09972, DUF2207, Predicted membrane protein (DUF2207). This domain, found in various hypothetical bacterial proteins, has no known function.	3.24455e-72
NZ_ALTB01000029.1\|WP_000031280.1\|12179_13442_-\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	1.81137e-126
NZ_ALTB01000029.1\|WP_000514047.1\|29852_31043_-\|argininosuccinate-synthase	gnl\|CDD\|234785	PRK00509, PRK00509, argininosuccinate synthase; Provisional.	0
NZ_ALTB01000029.1\|WP_000722379.1\|19354_20905_+\|ABC-transporter-substrate-binding-protein/permease	gnl\|CDD\|270345	cd13627, PBP2_AA_binding_like_2, Substrate-binding domain of putative amino acid-binding protein; the type 2 periplasmic-binding protein fold. This putative amino acid-binding protein belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.89439e-91
NZ_ALTB01000029.1\|WP_000164582.1\|28445_29834_-\|argininosuccinate-lyase	gnl\|CDD\|179143	PRK00855, PRK00855, argininosuccinate lyase; Provisional.	0
NZ_ALTB01000029.1\|WP_032457295.1\|31196_32267_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.39946e-50
NZ_ALTB01000029.1\|WP_000114502.1\|13478_14249_-\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	7.12681e-148
NZ_ALTB01000029.1\|WP_000173341.1\|10945_12178_-\|cysteine-desulfurase	gnl\|CDD\|131034	TIGR01979, Probable_cysteine_desulfurase, cysteine desulfurases, SufSfamily. This model represents a subfamily of NifS-related cysteine desulfurases involved in FeS cluster formation needed for nitrogen fixation among other vital functions. Many cysteine desulfurases are also active as selenocysteine lyase and/or cysteine sulfinate desulfinase. This subfamily is associated with the six-gene SUF system described in E. coli and Erwinia as an FeS cluster formation system during oxidative stress. The active site Cys is this subfamily resembles GHHC with one or both His conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	0
NZ_ALTB01000029.1\|WP_001140949.1\|25995_26184_-\|50S-ribosomal-protein-L28	gnl\|CDD\|234736	PRK00359, rpmB, 50S ribosomal protein L28; Reviewed.	2.94959e-21
NZ_ALTB01000029.1\|WP_000189496.1\|20914_21655_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.92009e-143

>NZ_ALTB01000029.1|WP_000189496.1|20914_21655_+|amino-acid-ABC-transporter-ATP-binding-protein
MTQAILEIKHLKKSYGSNEVLKDISLSVNKGEVISIIGSSGSGKSTFLRSINLLEEPSGGEILYHGHNVLEKGYDLNNYREKLGMVFQSFNLFENLNILENAIVAQTTVLKRERQEAEKIAKENLNAVGMTEQYWKAKPKQLSGGQKQRVAIARALSVNPEAILFDEPTSALDPEMVGEVLKTMQDLAKSGLTMIIVTHEMEFAKEVSDRVIFMDKGIIAEQGTPKQLFENPTQERTKEFLQRFLK
>NZ_ALTB01000029.1|WP_000722379.1|19354_20905_+|ABC-transporter-substrate-binding-protein/permease
MKKILLSLFTALLITFGGMTSIQADEYLRVGMEAAYAPFNWTQNDNTNGAVPIEGTDQYANGYDVQVAKKLAKKLNKKVVVVKTKWEGLVPALTSGKLDMIIAGMSPTEERKKEINFSKPYYISEPTLVVNAEGKYTNAKNISDFKNAKVTAQQGVYLYNLIDQINGVKKEVAMGDFNQLRQAVESGVVDAYVSERPDATSAQTANPKLKMIELHQGFKTSDADTNISVGMRKGDNRINQVNQVLESISRDKQIALMDKMIKEQPSVKKEKNGKPNFFEQMATILKNNGSQFLRGTATTLLISMVGTIVGLFIGLLIGVFRTAPKSDNKLKAALQKLLGWLLNIYIEVFRGTPMIVQSMVIYYGTAQAFGVSLDRTLAAIFIVSINTGAYMSEIVRGGIFSVDKGQFEAATALGFTHGQTMRKIVLPQVVRNILPATGNEFVINIKDTSVLNVISVVELYFSGNTVATQTYQYFQTFTIIAIIYFILTFTVTRILRYIEKRFDSDNYTTGANQLQV
>NZ_ALTB01000029.1|WP_000710515.1|17335_19219_-|DUF2207-domain-containing-protein
MKKCFLAICLALSFFMVSVQADEVDYNIPHYEGNLTIHNDNSADFTEKVTYQFDSSYNGQYVTLGTAGKLPDNFDINNKPQVEVSINGKVRKVSYQIEDLEDGYRLKVFNGGEAGDTVKVNVQWKLKNVLFMHKDVGELNWIPISDWDKTLEKVDFWISTDKKVALSRLWGHLGYLKTPPKIRQNNNRYHLTAFNVNKRLEFHGYWDRSYFNLPTNSKNNYKKKIEYQEKMIERHGFILSFLLRILLPSFFIIVTLFISIRVFLFRKKVNKYGQFPKEHHLYEAPEDLSPLELTQSIYSMSFKNFQDEEKKTHLISQEQLIQSILLDLIDRKVLNYDDNLLSLANLDRASDAEIDFIEFAFADSTSLKPDQLFSNYQFSYKETLRELKKQHKASDLQTQMRRRGSNALSRITRLTRLISKDNINSLRRKGISSPYRKMSSEESKELSRLKRFSYLSPLISFVVIIYTLFLNYFTYFCIYLLLFGVILLLNKIIFMMTRKISNGYIVTEDGASRVYQWTSFRNMLRDIKSFDRSELESIVLWNRILVYATLFGYADRVEKALRVNQIDIPERFANIDSHQFAISVNQSSNHFSTITEDVSHASNFSVNSGGSSGGFSGGGGGGGGGAF
>NZ_ALTB01000029.1|WP_000905327.1|16450_17290_-|undecaprenyl-diphosphate-phosphatase
MLIIELLKALFLGVVEGVTEWLPVSSTGHLILVQEFMKLNQSKSFVEMFNIVIQLGAIMAVIVIYFKRLNPFQPGKSAREIRLTWQLWLKVVIACIPSILIALPFDNWFEAHFNFMIPIAIALIFYGFVFIWVEKRNAHLKPQVTELASMSYKTAFLIGCFQVLSIVPGTSRSGATILGAIIIGTSRSVAADFTFFLAIPTMFGYSGLKAVKYFLDGNVLSLDQSLILLVASLTAFVVSLYVIRFLTDYVKRHDFTIFGKYRIVLGSLLILYWLVVHLF
>NZ_ALTB01000029.1|WP_000425371.1|15575_16331_-|adaptor-protein-MecA
MEMKQISETTLKITISMEDLEDRGMELKDFLIPQEKTEEFFYSVMDELDLPENFKNSGMLSFRVTPKKDRIDVFVTKSELSKDLNLEELADLGDISKMSPEDFFKTLEQSMLEKGDTDAHAKLAEIENMMDKATQEVVEENVSEEQPEKEVETIGYVHYVFDFDNIEAVVRFSQTIDFPIEASELYKNGKGYHMTILLDLENQPSYFANLMYARMLEHANVGTKTRAYLKEHSIQLIHDDAISKLQMIEMG
>NZ_ALTB01000029.1|WP_000612108.1|14413_15574_-|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MIPFTIEYIFVLIGAFLLSIILTPIIRVISLKVGAVDKPNARRINKVPMPSSGGLAIFLSFVVTTLFFMPMAASRHFIEVSYFHYILPVIIGGLVVTTTGFIDDIFELRPRYKMLGIIIAAIIIWKFTHFRFDSFKIPIGGPLLEFGPILTFFLTVLWIISITNAINLIDGLDGLVSGVSIISLATMAVVSYFFLPKIDFFLTLTIVILIASIVGFFPYNYHPAIIYLGDAGALFIGFMIGVLSLQGLKNSTAVAVITPVIILGVPILDTAVAIVRRKLSGKKISEADKMHLHHRLLSMGFTHRGAVLVVYGIAIIFSLIALLLNVSSRIGGIFLLLALLLAMEIFIEGLNIWGENRTPLFNLLKFIGNSDYRQSVIAKYSDKHQK
>NZ_ALTB01000029.1|WP_000114502.1|13478_14249_-|Fe-S-cluster-assembly-ATPase-SufC
MSVLEIKNLHVSIEDKEILKGLNLTLKTGEIAAIMGPNGTGKSTLSAAIMGNPNYEVTAGEILFDGEDILELEVDERARLGLFLAMQYPSEVPGITNAEFIRAAMNAGKADDDKISIRQFITKLDEKMELLGMKEEMAERYLNEGFSGGEKKRNEILQLLMLEPKFALLDEIDSGLDIDALKVVSKGVNEMRGEGFGAMIITHYQRLLNYITPDKVHVMMDGKVVLSGGPELAVRLEKEGYAQIAEELGLEYKEEV
>NZ_ALTB01000029.1|WP_000031280.1|12179_13442_-|Fe-S-cluster-assembly-protein-SufD
MSKEAILNFLQAKGEPTWLQELRLKAFEKIEELELPVIERVKFHRWNLGDGTILENDYTANVPDFTELGNNPKLVQIGTQTVLEQVPMELIEKGVVFTDFYSALEEIPEVIERYFGKARPFEEDRLAAYHTAYFNSGAVLYIPDNVEITQPIEGLFYQDSQSKVPFNKHILLIVGKNAKVSYLERFESIGDGTERTSANISVEVIAQAGSQIKFASIDRLGENVTTFISRRGRHSSDATIDWALGVMNEGNVVADFDSDLIGDGSHANLKVVAASSGRQVQGIDTRVTNYGCNSVGHILQHGVILERGTLTFNGIGHIIKGAKGADAQQESRVLMLSDKARSDANPILLIDENDVTAGHAASIGQVDPEDLYYLMSRGLNQKTAEQLVIRGFLGTVIAEIPVKEVRDEMIAVIDTKLEKR
>NZ_ALTB01000029.1|WP_000173341.1|10945_12178_-|cysteine-desulfurase
MTLLDSYKLKQDFPILNQLVNDEPLIYLDNAATTQKPNQVLEALRDYYQNDNANVHRGVHTLAERATAQYENAREKARQFLNAKLSKEILFTRGTTTGLNWVAKFAESILERGDEVLISIMEHHSNIIPWQQACERTGAKLVYAYLKDGSLDLEDFYNKLSSKTKFVSLAHISNVLGCVTPVKAIAERVHQVGAYMVVDGAQSAPHMAIDVQDLDCDFFALSGHKMLGPTGIGVLYGKESILDKMPPVEFGGEMIDFVYEQSATWKELPWKFEAGTPNIAGAIAFGEALDYLTDVGMDEIHQYEQSLVSYVLPKLQAIDGLTIYGPSDAESHVGVIAFNLEGLHPHDVATAMDYEGVAVRAGHHCAQPLINHLGIHSAVRASFYFYNTKEDCDKLVDAIQKTKEFFNGTL
>NZ_ALTB01000029.1|WP_001218456.1|10515_10959_-|SUF-system-NifU-family-Fe-S-cluster-assembly-protein
MALSKLDNLYMAVVADHSKHPHHHGFLEGVEQVQLNNPTCGDVISLSVKFDGNIISDIAFAGNGCTISTASSSMMTDAVIGKTKEEALQLADVFSKMVQGDQNPKQEKLGDAEFLAGVSKFPQRIKCATLSWNALRKAIERDNQAEL
>NZ_ALTB01000029.1|WP_000818733.1|22594_22711_+|putative-metal-homeostasis-protein
MAEKTDLSSAYRRLKSPNIKTRKRALKIIHEYKRYGKK
>NZ_ALTB01000029.1|WP_000052520.1|22802_23687_-|SPFH-domain-containing-protein
MSLIILTVILVLVIVLLITSLYVVKQQTVAIIERFGKYQKTATSGIHIRVPLGIDKIAARVQLRLLQSEIIVETKTKDNVFVTLNIATQYRVNENNVTDAYYKLIKPEAQIKSYIEDALRSSVPKLTLDELFEKKDEIALEVQHQVAEEMSTYGYIIVKTLITKVEPDAEVKQSMNEINAAQRKRVAAQELANADKIKIVTAAEAEAEKDRLHGVGIAQQRKAIVDGLADSIQELKDANVTLTEEQIMSILLTNQYLDTLNTFAINGNQTIFLPNNPEGVEDIRTQVLSALKTR
>NZ_ALTB01000029.1|WP_001868429.1|23834_25466_-|DAK2-domain-containing-protein
MVQAASTRLSKQAEYVNSLNVFPVPDGDTGTNMGMTMENGAKEVSDKPATTVGEVGQILSKGVLMGARGNSGVITSQLFRGFGQSIKDKEELTGQDLAHAFQNGVEVAYKAVMKPVEGTILTVSRGAATAALKKAEETDDAVEVMRATLKGAKRALAKTPDMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFKATPATMTEMVNAEHHKAVVGHVATEDIKYGYCTEVMVGLKQGPTYVKEFNYEEFQGYLSNLGDSLLVVNDDEIVKVHVHTEDPGLVMQEGLKYGSLVKVKVENMRNQHDAQMQKVEVEETVKETKEYGIIAVVAGDGLAEIFKSQGVDYIISGGQTMNPSTEDIVKAIEKVNARNVIILPNNKNIFMAAQSAADVVDIPAAVVETRTVPQGFTSLLAFDPAKSLETNVADMTNSLSDVISGSVTLAVRDTTIDGLEIHENDILGMVDGKILVSTPDMEKALKDTFDKMIDEDSEIVTIYVGEDGKQALAETLSEYLEETYEDVEVEIHQGDQPVYPYLMSVE
>NZ_ALTB01000029.1|WP_000216445.1|25498_25864_-|Asp23/Gls24-family-envelope-stress-response-protein
MTVKINTRDGQIELSDDVIATVVGGSATEIFGVVGMASKSAIKDNFQALLRKENYAKGVVVRSSEAGIVVDVYTVMSYGVKISEVSKNIQERVKFNLENQLGLSADMVNVYVQSIKVVGED
>NZ_ALTB01000029.1|WP_001140949.1|25995_26184_-|50S-ribosomal-protein-L28
MAKVCYFTGRKTVSGNNRSHAMNQTKRTVKPNLQKVTVLIDGKPKKVWVSARALKSGKVERV
>NZ_ALTB01000029.1|WP_000197060.1|26422_27340_+|L-lactate-dehydrogenase
MTRKIGIIGMGHVGSTVAHALIAQGIGDDYVFIDTNVDKVNADMIDFQDALANATYHANLVLNDYDALSDADVVISALGDISLQNNKEANRFAELPFTSKEVYDVSQKLKSSGFRGILIVVTNPVDAITQLYQEYTQFPKSRVIGTGTLLDTARMKRVLGQRLQVDPRSIGGYNLGEHGNSQFVAWSQVTVKGQPAISLLKAEELEQIKEASLKGGHTVFFGKKYTSYGIATAAVRIVLTVLNDSHELLPVSTFYESEGVYLGYPAIIGRVGIVERISLSLSPKEEQQLTDSAAFIRNYLKHINL
>NZ_ALTB01000029.1|WP_001018987.1|27423_28305_-|fructose-bisphosphate-aldolase
MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKLCKQLIETLVESMGITVPVAIHLDHGHYDDALECIEVGYTSIMFDGSHLPVEENLEKAREVVAKAHAKGISVEAEVGTIGGEEDGIVGKGELAPIEDAKAMVETGIDFLAAGIGNIHGPYPANWEGLDLDHLKKLTEAVPGFPIVLHGGSGIPDDQIQEAIKLGVAKVNVNTECQLAFCQATRDYAVEFNANEAEYMKKKLFDPRKFLKPGFDAITEAVEERIDVFGSANKA
>NZ_ALTB01000029.1|WP_000164582.1|28445_29834_-|argininosuccinate-lyase
MTKNHKLWGGRFESSLEKWVEEFGASISFDQKLAPYDMKASMAHVTMLGKTDIISQEEAGLIKDGLKILQDKYRAGQLTFSISNEDIHMNIESLLTAEIGEVAGKLHTARSRNDQVATDMHLYLKDKLQEMMKKLLHLRTTLVNLAENHIYTVMPGYTHLQHAQPISFGHHLMAYYNMFTRDTERLEFNMKHTNLSPLGAAALAGTTFPIDRHMTTRLLDFEKPYSNSLDAVSDRDFIIEFLSNASILMMHLSRFCEEIINWCSYEYQFITLSDTFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKSLPLAYNKDLQEDKEGMFDSVETVSIAIEIMANMLETMTVNEHIMMTSTETDFSNATELADYLASKGVPFRKAHEIVGKLVLECSKNGSYLQDIPLKYYQEISELIENDIYEILTAKTAVKRRNSLGGTGFDQVKKQILLARKELKAE
>NZ_ALTB01000029.1|WP_000514047.1|29852_31043_-|argininosuccinate-synthase
MGKEKLILAYSGGLDTSVAIAWLKKDYDVIAVCMDVGEGKDLDFIHDKALTIGAIESYILDVKDEFAEHFVLPALQAHAMYEQKYPLVSALSRPIIAQKLVEMAHQTGATTIAHGCTGKGNDQVRFEVAIAALDPELKVIAPVREWKWHREEEITFAKANGVPIPADLDNPYSIDQNLWGRANECGVLENPWNQAPEEAFGITKSPEEAPDCAEYIDITFQNGKPIAINNQEMTLADLILSLNEIAGKHGIGRIDHVENRLVGIKSREIYECPAAMVLLAAHKEIEDLTLVREVSHFKPILENELSNLIYNALWFSPATKAIIAYVKETQKVVNGTTKVKLYKGSAQVVARHSSNSLYDENLATYTAADSFDQDAAVGFIKLWGLPTQVNAQVNKG
>NZ_ALTB01000029.1|WP_032457295.1|31196_32267_-|HAMP-domain-containing-histidine-kinase
MTKLRRFRFPLRFYFTLMFVLTMLFSVLASLLLVAAIVFTFFQGVLTTHVLQVSALAVVFLSLVIASISMWYGSYHLTKPILDISHIVSNVADGDFEGHIYRNSNRRKSYEYYNELDELSESINQMIVSLSHMDHMRKDFITNVSHELKTPIAAVANIVELLQDPELDEETQSELLGLVKTESLRLARLCDTMLQMSRVDNHETIGELSSVRVDEQIRQAMISLTERWQAKRINFQLDSKPYTVYSNSDLLMQVWINLLDNAIKYSEDIVDLSVRMEETNNHYLRVIISDKGRGISQYDVQHIFDKFYQADQSHNQQGNGLGLAIVKRIIVLCKGRISVSSQLEIGTEFCVELPLS

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_ALTB01000029_1	1.1\|22134\|28\|NZ_ALTB01000029\|CRISPRCasFinder	22134-22161	28	CP016197	Bacillus thuringiensis serovar coreanensis strain ST7 plasmid pST7-3, complete sequence	59657-59684	7	0.75

1. spacer 1.1|22134|28|NZ_ALTB01000029|CRISPRCasFinder matches to CP016197 (Bacillus thuringiensis serovar coreanensis strain ST7 plasmid pST7-3, complete sequence) position: , mismatch: 7, identity: 0.75

gccttctgaatcaagctatccttcacgc	CRISPR spacer
tccatatgaatcaagctatccttctttg	Protospacer
 ** * ****************** .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

5. NZ_ALTB01000025

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

12360 : 28115

Streptococcus_phage(81.82%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001245437.1\|12360_14448_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.7e-60	29.9
WP_000711500.1\|14586_14793_-	copper chaperone TcrZ	NA	NA	NA	NA
WP_000103845.1\|15403_15850_-	CopY/TcrY family copper transport repressor	NA	NA	NA	NA
WP_000711078.1\|16307_16646_-	Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX	E4ZFI8	Streptococcus_phage	1.7e-10	33.3
WP_093998686.1\|16658_17285_-	CadD family cadmium resistance transporter	NA	NA	NA	NA
WP_000756015.1\|17346_18909_-	recombinase family protein	Q6DMS5	Streptococcus_phage	3.2e-213	71.7
WP_007891416.1\|18908_19820_-	recombinase family protein	M1NSJ1	Streptococcus_phage	1.2e-156	96.1
WP_000515884.1\|20205_21675_-	LysM peptidoglycan-binding domain-containing protein	A0A1X9I678	Streptococcus_phage	3.5e-262	92.8
WP_000661395.1\|21681_22077_-\|holin	phage holin family protein	A0A1B0RXK5	Streptococcus_phage	3.2e-45	99.2
WP_000922387.1\|22054_22261_-	hypothetical protein	A0A1B0RXE8	Streptococcus_phage	1.5e-14	92.5
WP_001058366.1\|22897_23257_+	winged helix-turn-helix transcriptional regulator	E4ZFI8	Streptococcus_phage	2.7e-22	47.3
WP_001291323.1\|23253_25371_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	3.1e-235	62.7
WP_001875682.1\|26073_26304_+	CHAP domain-containing protein	H7BV84	unidentified_phage	7.0e-08	40.0
WP_000490874.1\|26416_27187_-	ABC transporter permease	NA	NA	NA	NA
WP_000119359.1\|27179_28115_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	5.2e-25	31.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

6. NZ_ALTB01000020

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CRISPR-Cas detection and classification

Crispr_ID: NZ_ALTB01000020_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_ALTB01000020_1

120727-121554

Orphan

II-A

Consensus_repeat	Method
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CRISPRCasFinder
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	CRT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	PILER-CR

12 spacers

The CRISPR arrays of NZ_ALTB01000020_1

>merge|NZ_ALTB01000020|1|120727-121554|CRISPRCasFinder,CRT,PILER-CR
TTTAACGTGCTGTGCTGTTTCGAATGGTTCCAAAACTAATTAAAAACAAAAAGCCCCAAAACCTGTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACATTTGACAAACATTGAACTTAAAAGAAACTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTTTATTACACGCTTGTTGAATTTCACGAGTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTCCATATAATGCTAACTCAGCATCATTCTCGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAGGTGCACTCGCACCATTGCAAACACTGGAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTCGTAGTATGTCGCTTTTGGTTGCAACTCCGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGGAGAACCTTGACATCATTGCTAAACGCACGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAATCAGAGCTTTACAACGCAATTGTTGATAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGTAAAAACTTGTGTTTTTTTTGTGTTTGAAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACGGAAGATAACACTATTTTTTCAATTCCTGAGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACTGGTTATACATTTACTAATCCATCAGCATTGTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAACAAGCTAATTCTCATCTCACCGAGATGGATAGTTTTAGAGCTGTGCTGTTATTATGCTAGGACATCA

>NZ_ALTB01000020|1|1|120727-121488|CRISPRCasFinder
TTTAACGTGCTGTGCTGTTTCGAATGGTTCCAAAAC	TAATTAAAAACAAAAAGCCCCAAAACCTGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	ATTTGACAAACATTGAACTTAAAAGAAACT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTTATTACACGCTTGTTGAATTTCACGAGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCCATATAATGCTAACTCAGCATCATTCTC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGGTGCACTCGCACCATTGCAAACACTGGA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCGTAGTATGTCGCTTTTGGTTGCAACTCC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGAGAACCTTGACATCATTGCTAAACGCAC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AATCAGAGCTTTACAACGCAATTGTTGATA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GTAAAAACTTGTGTTTTTTTTGTGTTTGAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGAAGATAACACTATTTTTTCAATTCCTGA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGGTTATACATTTACTAATCCATCAGCATT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC

>NZ_ALTB01000020|1|1|120727-121554|CRT
TTTAACGTGCTGTGCTGTTTCGAATGGTTCCAAAAC	TAATTAAAAACAAAAAGCCCCAAAACCTGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	ATTTGACAAACATTGAACTTAAAAGAAACT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTTATTACACGCTTGTTGAATTTCACGAGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCCATATAATGCTAACTCAGCATCATTCTC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGGTGCACTCGCACCATTGCAAACACTGGA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCGTAGTATGTCGCTTTTGGTTGCAACTCC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGAGAACCTTGACATCATTGCTAAACGCAC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AATCAGAGCTTTACAACGCAATTGTTGATA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GTAAAAACTTGTGTTTTTTTTGTGTTTGAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGAAGATAACACTATTTTTTCAATTCCTGA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGGTTATACATTTACTAATCCATCAGCATT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AAGCTAATTCTCATCTCACCGAGATGGATA
GTTTTAGAGCTGTGCTGTTATTATGCTAGGACATCA

>NZ_ALTB01000020|1|1|120793-121488|PILER-CR
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	ATTTGACAAACATTGAACTTAAAAGAAACT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TTTATTACACGCTTGTTGAATTTCACGAGT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCCATATAATGCTAACTCAGCATCATTCTC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AGGTGCACTCGCACCATTGCAAACACTGGA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TCGTAGTATGTCGCTTTTGGTTGCAACTCC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGAGAACCTTGACATCATTGCTAAACGCAC
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	AATCAGAGCTTTACAACGCAATTGTTGATA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GTAAAAACTTGTGTTTTTTTTGTGTTTGAA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	GGAAGATAACACTATTTTTTCAATTCCTGA
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC	TGGTTATACATTTACTAATCCATCAGCATT
GTTTTAGAGCTGTGCTGTTTCGAATGGTTCCAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_ALTB01000020.1\|WP_000146565.1\|133210_133849_-\|CatB-related-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100040
NZ_ALTB01000020.1\|WP_000438314.1\|122111_122528_+\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
NZ_ALTB01000020.1\|WP_000168898.1\|129193_131986_+\|cation-transporting-P-type-ATPase	unknown	unknown	gnl\|CDD\|223550
NZ_ALTB01000020.1\|WP_001241816.1\|116824_117205_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131381
NZ_ALTB01000020.1\|WP_000180007.1\|127475_128135_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|224336
NZ_ALTB01000020.1\|WP_000323544.1\|119168_119939_+\|TIGR01457-family-HAD-type-hydrolase	unknown	unknown	gnl\|CDD\|319832
NZ_ALTB01000020.1\|WP_000653357.1\|119928_120585_+\|TIGR01906-family-membrane-protein	unknown	unknown	gnl\|CDD\|226884
NZ_ALTB01000020.1\|WP_001019133.1\|122663_124496_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
NZ_ALTB01000020.1\|WP_000700880.1\|111603_112947_-\|Mur-ligase-family-protein	unknown	unknown	gnl\|CDD\|223840
NZ_ALTB01000020.1\|WP_000621142.1\|128143_128608_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_ALTB01000020.1\|WP_000713236.1\|113940_114900_+\|YbbR-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|227193
NZ_ALTB01000020.1\|WP_000350949.1\|113086_113938_+\|TIGR00159-family-protein	unknown	unknown	gnl\|CDD\|224539
NZ_ALTB01000020.1\|WP_000665410.1\|128607_129042_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	unknown	unknown	gnl\|CDD\|234692
NZ_ALTB01000020.1\|WP_000521427.1\|114953_116306_+\|phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670
NZ_ALTB01000020.1\|WP_000467138.1\|135207_135990_-\|hypothetical-protein	unknown	unknown	unknown
NZ_ALTB01000020.1\|WP_000159234.1\|116428_116800_+\|YbgA-family-protein	unknown	unknown	gnl\|CDD\|377982
NZ_ALTB01000020.1\|WP_001056394.1\|134559_135171_+\|TVP38/TMEM64-family-protein	unknown	unknown	gnl\|CDD\|223475
NZ_ALTB01000020.1\|WP_000914664.1\|117296_118427_+\|oxygen-independent-coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|236309
NZ_ALTB01000020.1\|WP_011058334.1\|121808_121979_+\|hypothetical-protein	unknown	unknown	unknown
NZ_ALTB01000020.1\|WP_000523795.1\|118430_119168_+\|acyl-ACP-thioesterase	unknown	unknown	gnl\|CDD\|366738

Protein	Function_ID	Function_description	E-value
NZ_ALTB01000020.1\|WP_000146565.1\|133210_133849_-\|CatB-related-O-acetyltransferase	gnl\|CDD\|100040	cd03349, LbH_XAT, Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. Members of this class of enzymes include Enterococcus faecium streptogramin A acetyltransferase and Pseudomonas aeruginosa chloramphenicol acetyltransferase. They contain repeated copies of a six-residue hexapeptide repeat sequence motif (X-[STAV]-X-[LIV]-[GAED]-X) and adopt a left-handed parallel beta helix (LbH) structure. The active enzyme is a trimer with CoA and substrate binding sites at the interface of two separate LbH subunits. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients.	6.8383e-72
NZ_ALTB01000020.1\|WP_000914664.1\|117296_118427_+\|oxygen-independent-coproporphyrinogen-III-oxidase	gnl\|CDD\|236309	PRK08599, PRK08599, oxygen-independent coproporphyrinogen III oxidase.	0
NZ_ALTB01000020.1\|WP_000168898.1\|129193_131986_+\|cation-transporting-P-type-ATPase	gnl\|CDD\|223550	COG0474, MgtA, Cation transport ATPase [Inorganic ion transport and metabolism].	0
NZ_ALTB01000020.1\|WP_001241816.1\|116824_117205_+\|hypothetical-protein	gnl\|CDD\|131381	TIGR02328, TIGR02328, conserved hypothetical protein. Members of this protein are found in a small number of taxonomically well separated species, yet are strongly conserved, suggesting lateral gene transfer. Members are found in Treponema denticola, Clostridium acetobutylicum, and several of the Firmicutes. The function of this protein is unknown. [Hypothetical proteins, Conserved].	6.45558e-80
NZ_ALTB01000020.1\|WP_000180007.1\|127475_128135_+\|HD-domain-containing-protein	gnl\|CDD\|224336	COG1418, COG1418, Predicted HD superfamily hydrolase [General function prediction only].	2.66997e-33
NZ_ALTB01000020.1\|WP_000323544.1\|119168_119939_+\|TIGR01457-family-HAD-type-hydrolase	gnl\|CDD\|319832	cd07530, HAD_Pase_UmpH-like, UmpH/NagD family phosphatase, similar to Escherichia coli UmpH UMP phosphatase/NagD nucleotide phosphatase and Mycobacterium tuberculosis Rv1692 glycerol 3-phosphate phosphatase. Escherichia coli UmpH/NagD is a ribonucleoside tri-, di-, and monophosphatase with a preference for purines, it shows peak activity with UMP and functions in UMP-degradation. It is also an effective phosphatase with AMP, GMP and CMP. Mycobacterium tuberculosis phosphatase, Rv1692 is a glycerol 3-phosphate phosphatase. Rv1692 is the final enzyme involved in glycerophospholipid recycling/catabolism. This subfamily belongs to the UmpH/NagD phosphatase family, and to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.19143e-132
NZ_ALTB01000020.1\|WP_000653357.1\|119928_120585_+\|TIGR01906-family-membrane-protein	gnl\|CDD\|226884	COG4478, COG4478, Predicted membrane protein [Function unknown].	9.75792e-52
NZ_ALTB01000020.1\|WP_001019133.1\|122663_124496_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
NZ_ALTB01000020.1\|WP_000700880.1\|111603_112947_-\|Mur-ligase-family-protein	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	1.84077e-96
NZ_ALTB01000020.1\|WP_000621142.1\|128143_128608_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.91796e-19
NZ_ALTB01000020.1\|WP_000713236.1\|113940_114900_+\|YbbR-like-domain-containing-protein	gnl\|CDD\|227193	COG4856, COG4856, Uncharacterized protein conserved in bacteria [Function unknown].	4.41106e-81
NZ_ALTB01000020.1\|WP_000350949.1\|113086_113938_+\|TIGR00159-family-protein	gnl\|CDD\|224539	COG1624, COG1624, Uncharacterized conserved protein [Function unknown].	3.31979e-97
NZ_ALTB01000020.1\|WP_000665410.1\|128607_129042_+\|peptide-methionine-(R)-S-oxide-reductase-MsrB	gnl\|CDD\|234692	PRK00222, PRK00222, peptide-methionine (R)-S-oxide reductase MsrB.	6.40832e-86
NZ_ALTB01000020.1\|WP_000521427.1\|114953_116306_+\|phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
NZ_ALTB01000020.1\|WP_001056394.1\|134559_135171_+\|TVP38/TMEM64-family-protein	gnl\|CDD\|223475	COG0398, COG0398, Uncharacterized conserved protein [Function unknown].	6.1265e-31
NZ_ALTB01000020.1\|WP_000438314.1\|122111_122528_+\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	4.64422e-78
NZ_ALTB01000020.1\|WP_000159234.1\|116428_116800_+\|YbgA-family-protein	gnl\|CDD\|377982	pfam08349, DUF1722, Protein of unknown function (DUF1722). This domain of unknown function is found in bacteria and archaea and is homologous to the hypothetical protein ybgA from E. coli.	6.08694e-28
NZ_ALTB01000020.1\|WP_000523795.1\|118430_119168_+\|acyl-ACP-thioesterase	gnl\|CDD\|366738	pfam01643, Acyl-ACP_TE, Acyl-ACP thioesterase. This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via hydrolysing an acyl group on a fatty acid.	3.68196e-111

>NZ_ALTB01000020.1|WP_000653357.1|119928_120585_+|TIGR01906-family-membrane-protein
MKDKLLVVLTWIWIISLATLATIYIAWLIYPIEIQFLKLEKVVYLKAETIYYNFNKLMIYLTHPFISDLNMPSFPSSEDGLKHFADVKYLFTLAHGLFVILTFPVIYFLRRGWKQKSIFLYEGFFKIAIMLPIFIVVCAFLLGFDQFFTLFHEVLFPGDSTWQFNPLTDPVIWILPETFFLHCFIIFLLIYETITIILLIIGRKHLKLRKYKNKMQAL
>NZ_ALTB01000020.1|WP_000323544.1|119168_119939_+|TIGR01457-family-HAD-type-hydrolase
MAYKGYLIDLDGTIYKGKSRIPAGERFIERLQEKGIPYMLVTNNTTRTPESVQEMLRGFNVETPLETIYTATMATVDYMNDMNRGKTAYVIGEEGLKKAIADAGYVEDTKNPAYVVVGLDWNVTYDKLATATLAIQNGALFIGTNPDLNIPTERGLLPGAGSLNALLEAATRIKPVFIGKPNAIIMNKALEILNIPRNQAVMVGDNYLTDIMAGINNDIDTLLVTTGFTTVEEVPDLPIQPSYVLASLDEWTFNEG
>NZ_ALTB01000020.1|WP_000523795.1|118430_119168_+|acyl-ACP-thioesterase
MGLLYRETYEVPFYESDTNHYMKLPQLLALALQISAKQSLKLGIGDDIVFKRYGLVWVVTDYIIDIERLPKHAEKIVIETEAKAHNKLLCYRYFYIYGEDGQKIITISSAFVLMDFKTRKIHPVLDDITSIYQSQRIKKVIRGPKYHPIGDSKVKQYHVRYFDLDMNGHVNNSKYLEWMYDVLDLDFLSSHIPKKIDLKYIKEIQYGTDIKSHWYQDGLVTRHDIIGGDAIHAQARIEWQEKKED
>NZ_ALTB01000020.1|WP_000914664.1|117296_118427_+|oxygen-independent-coproporphyrinogen-III-oxidase
MLKKPTSAYVHIPFCTQICYYCDFSKVFIKNQPVDAYLQALIREFRSYDITELRTLYIGGGTPTSISAVQLDYLLTELSRDLNLNTLEEFTIEANPGDLTVDKIEVLQKSAVNRVSLGVQTFNDKHLKRIGRSHNEAQIYSTIDALKTAGFQNISIDLIYALPGQTMDDVRSNVAKALSLNIPHLSLYSLILEHHTVFMNKMRRGKLHLPTEDLEAEMFEYIISEMERNGFEHYEISNFTKPGFESRHNLMYWDNVEYYGVGAGASGYLDGIRYRNRGPIQHYLKGVSEGNARLSEEVLSKNEMMEEELFLGLRKKEGVSIGKFEQKFGTSFEKRYGQIVQELQSDGLLKENNGFIQMTKKGLFLGDTVAEKFIVE
>NZ_ALTB01000020.1|WP_001241816.1|116824_117205_+|hypothetical-protein
MRLWHQDIIELLPRQQLLGQHRECCALRGNGWGRKHETVDYVFRYSPYRLFAYHQLVMEEMMERGYRVSKEWLIAEYRGMKCPRYDTLNPVDLETPIYPEHNQDYLQECLWNLKAKGIDLPINKIK
>NZ_ALTB01000020.1|WP_000159234.1|116428_116800_+|YbgA-family-protein
MTKEAELLWAKHKYLVLSKSQKIYLDIRQTLKSPNCTVLDVQSLIDQAVLLEESPSQVTNAYMHIWGYFKNKAERQEKEEFLTLLEKYRKTGYQRRKLLAFLKQLLAKYPNSYLQNSSIFEEE
>NZ_ALTB01000020.1|WP_000521427.1|114953_116306_+|phosphoglucosamine-mutase
MGKYFGTDGVRGEANVELTPELAFKLGRFGGYVLSQHETDRPRVFVARDTRISGEMLESALIAGLLSVGIEVYKLGVLATPGVSYLVRTEKASAGVMISASHNPALDNGIKFFGSDGFKLDDDRELEIEALLDAKEDTLPRPSAQGLGTLVDYPEGLRKYEKFMESTGIDLEGMKVALDTANGAATASARNIFLDLNADISVIGDQPDGLNINDGVGSTHPEQLQSLVRENGSDIGLAFDGDSDRLIAVDENGEIVDGDKIMFIIGKYLSDKGQLAQNTIVTTVMSNLGFHKALDREGIHKAITAVGDRYVVEEMRKSGYNLGGEQSGHVIIMDYNTTGDGQLTAIQLTKVMKETGKKLSELASEVTIYPQKLVNIRVENNMKDKAMEVPAIAEIIAKMEEEMDGNGRILVRPSGTEPLLRVMAEAPTNEAVDYYVDTIADVVRTEIGLD
>NZ_ALTB01000020.1|WP_000713236.1|113940_114900_+|YbbR-like-domain-containing-protein
MKKFFTNKFWLGVVSLFLAILLFLTATATSMNHQDNSKIAGASETYTHTLTDVPIDIKYDSDDYFISGYSYGADVYMSSVNRVKLDSEINEDTRKFKVVADLTNMKPGTHKVPLKVVNLPSGVNATVSPTTITVTMGKKKTKEFPVYGHVNDKQIKAGYAVDKMSVDVSKVKVTSDESIIDRIDHVAANIPDDKVLDDDFNKTVTLQAVTADGTVLASIIHPSKATLSVKVKKLTKTVPINLIPVGQFSDSISKINYKLSQEKAVISGTKEALEAISVINAEVDISDVTKNTEKKINLSANNVSVDPAQVTVQLTTTKK
>NZ_ALTB01000020.1|WP_000350949.1|113086_113938_+|TIGR00159-family-protein
MDIFSAIDSKFWASIMENPWMILIHLMDIIIVAVLIYKFIKALAGTKIMSLIQGVILFIIIRFVSEWIGLTTITFLMNQIVTYGVIAGVVIFAPEIRTGLEKFGRTPQLFTQRSQLSSDEKLVDALVKAVAYMSPRKIGALISIERTQTLQEYIATGIPLDADISSELLINIFIPNTPLHDGAVIVKDKKIATACSYLPLSESSSISKEFGTRHRAAIGLSENSDALTVIVSEETGGISVALKGEFLHDLSKDSFEAILRTQLIQNQEENSKLAWYNQLLRRK
>NZ_ALTB01000020.1|WP_000700880.1|111603_112947_-|Mur-ligase-family-protein
MKINTALGVAAGKSAHYLLSKMGRGSTYPGSLALKFDKDILDTIAKDYEIVVVTGTNGKTLTTALTVGILKEAFGQVVTNPSGANMITGIVSTFLTAKKSKSGKKIAVLEIDEASLPRITQYIKPSLFVFTNIFRDQMDRYGEIYTTYQMILDGAANAPQATILANGDSPLFNSKSVTNPVQFYGFNTDKHEPRLAHYNTEGILCPKCQAILTYRLNTYANLGDYTCPNCDFERPNLDYALTRLTHLTNTSSGFVIDGQQYNINVGGLYNIYNALAAVSVAEYFGVEPSQIKDGFDKSRAVFGRQETFTIGNKKCTLVLIKNPVGASQALDMIKLAPYPFSLSVLLNANYADGIDTSWIWDANFETILTMNIPEIFAGGVRHSEIARRLRVTGYDEKRIKQADKLQDIMTMIEQQETEHAYILATYTAMLEFREILANHNAIRKEMN
>NZ_ALTB01000020.1|WP_011058334.1|121808_121979_+|hypothetical-protein
MKGYNSNLMVKGLGCSTLYLIISLTALVLLVIAGVFFVINTCKLTRKAVENLSIIN
>NZ_ALTB01000020.1|WP_000438314.1|122111_122528_+|nucleoside-diphosphate-kinase
MEQTFFMIKPDGVKRGFIGEVISRIERRGFSIDRLEVRYADADILKRHYAELTDRPFFPTLVDYMTSGPVIIGVISGEEVISTWRTMMGSTNPKDALPGTIRGDFAQAPSPNQATCNIVHGSDSPESATREIAIWFNN
>NZ_ALTB01000020.1|WP_001019133.1|122663_124496_+|elongation-factor-4
MNIEDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRAEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGEVDAPLQALIFDSVYDAYRGVILQVRIVNGMVKPGDKIQMMSNGKTFDVTEVGIFTPKAVGRDFLATGDVGYIAASIKTVADTRVGDTITLANNPAIEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSEFPDPTRVDSIEEPYVKAQIMVPQEFVGAVMELAQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYEISEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDDKK
>NZ_ALTB01000020.1|WP_000180007.1|127475_128135_+|HD-domain-containing-protein
MTMVKREDVILNATENMVHHKLKNDPSGHDWFHIVRVRNLAVELAHKEGANTFICQMAALLHDIIDDKICQDSKQASYELTQWLYSQDLAIAEVEHILDILENISFKAGTGLTMKTLEGQIVQDADRLDAMGAIGIARTMAYSGSKGRLIHDPNLKPRENLTLEEYRNGQDTAIMHFYEKLLKLKDLMNTKQGKMLAQKRHDFLELYLAEFYAEWNGKR
>NZ_ALTB01000020.1|WP_000621142.1|128143_128608_+|GNAT-family-N-acetyltransferase
MIRRAKEKDLPDIAELLKQILMLHHEVRPDIFHTRGSKFSKEQLKEMLIDESKPIFVYESDEGKVVAHLFLQLQEKRDLPRKSFKTLYIDDLCIDEEVRGQQIGQKLMDFARQYAKKHGCYNITLNVWNDNQRAVSFYEKLGFKPQQTQMEEIL
>NZ_ALTB01000020.1|WP_000665410.1|128607_129042_+|peptide-methionine-(R)-S-oxide-reductase-MsrB
MKETQEELRQRIGHTAYQVTQNSATEHAFTGKYDDFFEEGIYVDIVSGEVLFSSLDKFQSGCGWPAFSKPIENRMVTNHQDHSHGMHRIEVRSRQADSHLGHVFNDGPVDAGGLRYCINSAALDFIPYDQMAKRGYGDYLSLFD
>NZ_ALTB01000020.1|WP_000168898.1|129193_131986_+|cation-transporting-P-type-ATPase
MASTNNVSDTNTRFAKEELEEVFEELGTTQGGLSDEEVAVRQKKYGLNLLSEVKQESIILLFLKNFTSLMAILLWVGGFVAIVSNSLELGLAIWMVNVINGIFSFIQEYRASQATQALEKMLPSYSRVLRKGSEEKILSEQLVPGDIVLIEEGDRISADGRLIKTTDLQVNQSALTGESNPIYKDSNVENDQSKTLIECDNMVFAGTTVSSGSATMVVTAIGMQTQFGQIADLTQGMKSEKSPLQRELDRLTKQISIISITVGIIFFLAATFFVKEPVSKSFIFALGMIVAFIPEGLLPTVTLSLAMAVQRMAKEHALVKKLSSVETLGATSVICSDKTGTLTQNEMTVNHLWQNGKSYQVTGLGYAPEGQILFEGDNICFGNSDRGDLEKLIRFAHLCSNAQVLPPNDDRSTYTVLGDPTEACLNVLLEKSGINIQENRKFAPRLKELPFDSVRKRMTTIHSLGGDEKDKKISITKGAPKEILDLSDYVLSDGKVIPLNKEERNKIQLANDTFAKDGLRVLAVSYCDIEGFSKEQWTQENLEQHMVFIGLIAMSDPPREGVREAIDKCHAASIRIIMVTGDYGLTALSIAKNIGIIRNDDAKVISGLELSEMTDSQLKKELSGEVVFARVAPEQKYRVVTILQEMGEVVAVTGDGVNDAPALKKSDIGVAMGVTGTDVAKESADMILTDDHFASIVHAVEEGRAVYQNIKKFLTYIFNSNTPEAVPSAFFLFSKGFIPLPLTVMQILAVDLGTDMLPALGLGVEPPETDVMNRPPRRLTDRLLDKGLLIKSFLWYGTIESVLAMGGFFWAHYLRYGNFTFFVANGIPYREATTMTLGAIIFSQIGMVMNSRTSYQSIKALSIFGNKLINFGIIMEILAFLVLVYVPLFHNLFNTASLGLSHWLYLISCPFIMIGLDEVRKLFSSRKNKR
>NZ_ALTB01000020.1|WP_000146565.1|133210_133849_-|CatB-related-O-acetyltransferase
MASILKKHLEKRLELKNDPMRTDMSTGASYPKYGFSVGKYTYGYQQFFYEGVNLKEIGAFCSIAQNVTITGLNHPTDHITTNPFIYYKSRGFINEDRADLIDEKKNGKVIIGNDVWIGTNVTILPSVTIGNGAIIGAGSVITKDIPDYAVVAGTPAKIIKYRFSEEEITLLNASQWWNWSDEAIKEHISEFSDKKEFFNTLKSISENKNHKL
>NZ_ALTB01000020.1|WP_001056394.1|134559_135171_+|TVP38/TMEM64-family-protein
MNMKLSKRYRFWQKVIKALGVLALIATLVLVVYLYKLGILNDSNELKDLVHKYEFWGPMIFIVAQIVQIVFPVIPGGVTTVAGFLIFGPTLGFIYNYIGIIIGSVILFWLVKFYGRKFVLLFMDQKTFDKYESKLETSGYEKFFIFCMASPISPADIMVMITGLSNMSIKRFVTIIMITKPISIIGYSYLWIYGGDILKNFLN
>NZ_ALTB01000020.1|WP_000467138.1|135207_135990_-|hypothetical-protein
MFGKLLKYELKSVGKWYLTLNAAVLLVSIILGLVLKALGGNFSTDTNSTSAQIFTIILVLLLAMVISGSLLSTLAIIIKRFYSNIFGRQGYLTLTLPVTTNQIICSKLLASLLWSIFNIFIVIIGIILVILPLVGIGQFVVAFPEIYKIISSSNAPLFIAYFFLSYVAGTLLIYLSIAVGQLFTNKRVLMGIVSYFGISLLITFLTLIIDSIFHIDLFNSHANATFSQPVLLYNILVSIVEIAIFYMLTHSIIKYKLNIQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_ALTB01000020_1	1.1\|120763\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT	120763-120792	30	MK448971	Streptococcus phage Javan52, complete genome	23384-23413	0	1.0
NZ_ALTB01000020_1	1.1\|120763\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT	120763-120792	30	MK448956	Streptococcus phage Javan48, complete genome	21703-21732	0	1.0
NZ_ALTB01000020_1	1.3\|120895\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120895-120924	30	MK448708	Streptococcus phage Javan23, complete genome	18777-18806	0	1.0
NZ_ALTB01000020_1	1.3\|120895\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120895-120924	30	MK448897	Streptococcus phage Javan28, complete genome	18777-18806	0	1.0
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	MK448708	Streptococcus phage Javan23, complete genome	19730-19759	0	1.0
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	MK448897	Streptococcus phage Javan28, complete genome	19730-19759	0	1.0
NZ_ALTB01000020_1	1.7\|121159\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121159-121188	30	MK448708	Streptococcus phage Javan23, complete genome	20130-20159	1	0.967
NZ_ALTB01000020_1	1.7\|121159\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121159-121188	30	MK448897	Streptococcus phage Javan28, complete genome	20130-20159	1	0.967
NZ_ALTB01000020_1	1.1\|120763\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT	120763-120792	30	MK448851	Streptococcus phage Javan14, complete genome	22357-22386	2	0.933
NZ_ALTB01000020_1	1.8\|121225\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121225-121254	30	MK448925	Streptococcus phage Javan386, complete genome	20996-21025	2	0.933
NZ_ALTB01000020_1	1.8\|121225\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121225-121254	30	MK448927	Streptococcus phage Javan394, complete genome	21593-21622	2	0.933
NZ_ALTB01000020_1	1.8\|121225\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121225-121254	30	MK448905	Streptococcus phage Javan318, complete genome	22917-22946	4	0.867
NZ_ALTB01000020_1	1.6\|121093\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121093-121122	30	MK448738	Streptococcus phage Javan355, complete genome	3891-3920	5	0.833
NZ_ALTB01000020_1	1.8\|121225\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121225-121254	30	MK448834	Streptococcus phage Javan91, complete genome	21602-21631	5	0.833
NZ_ALTB01000020_1	1.8\|121225\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121225-121254	30	MK449009	Streptococcus phage Javan88, complete genome	23306-23335	5	0.833
NZ_ALTB01000020_1	1.1\|120763\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT	120763-120792	30	MT773557	Myoviridae sp. isolate BML_S_1 genomic sequence	9766-9795	6	0.8
NZ_ALTB01000020_1	1.9\|121291\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121291-121320	30	KJ018210	Flavobacterium sp. phage 1/32, complete genome	3123-3152	6	0.8
NZ_ALTB01000020_1	1.9\|121291\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121291-121320	30	MN698242	Pelagibacter phage HTVC103P, complete genome	26922-26951	6	0.8
NZ_ALTB01000020_1	1.11\|121423\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121423-121452	30	NC_047897	Lactobacillus phage Lenus, complete genome	65427-65456	6	0.8
NZ_ALTB01000020_1	1.11\|121423\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121423-121452	30	AP013698	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C55A-MedDCM-OCT-S36-C68, * SEQUENCING IN PROGRESS *	17874-17903	6	0.8
NZ_ALTB01000020_1	1.2\|120829\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120829-120858	30	NC_015937	Thermus phage TMA, complete genome	108316-108345	7	0.767
NZ_ALTB01000020_1	1.2\|120829\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120829-120858	30	MH595538	Vibrio phage BONAISHI, complete genome	251052-251081	7	0.767
NZ_ALTB01000020_1	1.2\|120829\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120829-120858	30	AP011617	Thermus phage TMA DNA, complete genome	108316-108345	7	0.767
NZ_ALTB01000020_1	1.5\|121027\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121027-121056	30	NZ_CP046475	Janibacter melonis strain M714 plasmid unnamed, complete sequence	43207-43236	7	0.767
NZ_ALTB01000020_1	1.8\|121225\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121225-121254	30	MK448878	Streptococcus phage Javan224, complete genome	19710-19739	7	0.767
NZ_ALTB01000020_1	1.9\|121291\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121291-121320	30	NZ_CP009417	Jeotgalibacillus malaysiensis strain malaysiensis plasmid unnamed, complete sequence	457990-458019	7	0.767
NZ_ALTB01000020_1	1.11\|121423\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121423-121452	30	NC_047925	Lactobacillus phage Nyseid, complete genome	67879-67908	7	0.767
NZ_ALTB01000020_1	1.11\|121423\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121423-121452	30	KU052488	Lactobacillus phage SA-C12, complete genome	24549-24578	7	0.767
NZ_ALTB01000020_1	1.11\|121423\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121423-121452	30	MN693473	Marine virus AFVG_25M504, complete genome	22237-22266	7	0.767
NZ_ALTB01000020_1	1.1\|120763\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT	120763-120792	30	MN693770	Marine virus AFVG_250M115, complete genome	119-148	8	0.733
NZ_ALTB01000020_1	1.1\|120763\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT	120763-120792	30	MN693770	Marine virus AFVG_250M115, complete genome	41262-41291	8	0.733
NZ_ALTB01000020_1	1.1\|120763\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT	120763-120792	30	NZ_CP021457	Lactobacillus brevis strain ZLB004 plasmid p1, complete sequence	63596-63625	8	0.733
NZ_ALTB01000020_1	1.1\|120763\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT	120763-120792	30	NZ_CP040048	Acinetobacter baumannii strain VB1190 plasmid unnamed1, complete sequence	276204-276233	8	0.733
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	HG983280	Aliivibrio salmonicida plasmid pVSAL68, strain Vs289, complete sequence	5359-5388	8	0.733
NZ_ALTB01000020_1	1.7\|121159\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121159-121188	30	MF042360	Pseudomonas phage Phabio, complete genome	99564-99593	8	0.733
NZ_ALTB01000020_1	1.9\|121291\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121291-121320	30	AP014379	Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S43-C51, * SEQUENCING IN PROGRESS *	12982-13011	8	0.733
NZ_ALTB01000020_1	1.9\|121291\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121291-121320	30	MN850656	Flavobacterium phage fF4, complete genome	9934-9963	8	0.733
NZ_ALTB01000020_1	1.11\|121423\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121423-121452	30	AP018932	Escherichia phage KIT03 DNA, complete sequence	154828-154857	8	0.733
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	HG983279	Aliivibrio salmonicida plasmid pVSAL111, strain TEO83.001, complete sequence	5373-5402	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	HG983279	Aliivibrio salmonicida plasmid pVSAL111, strain TEO83.001, complete sequence	9700-9729	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	NC_011314	Aliivibrio salmonicida LFI1238 plasmid pVSAL320, complete sequence	12759-12788	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	NC_011314	Aliivibrio salmonicida LFI1238 plasmid pVSAL320, complete sequence	20962-20991	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	NC_011314	Aliivibrio salmonicida LFI1238 plasmid pVSAL320, complete sequence	30723-30752	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	NZ_CP034239	Aliivibrio salmonicida strain VS224 plasmid pVS320-224, complete sequence	5317-5346	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	NZ_CP034239	Aliivibrio salmonicida strain VS224 plasmid pVS320-224, complete sequence	13516-13545	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	NZ_CP034239	Aliivibrio salmonicida strain VS224 plasmid pVS320-224, complete sequence	23069-23098	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	NZ_CP034239	Aliivibrio salmonicida strain VS224 plasmid pVS320-224, complete sequence	29849-29878	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	NZ_CP007625	Bacillus pseudomycoides strain 219298 plasmid unnamed, complete sequence	213223-213252	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	NZ_CP009650	Bacillus pseudomycoides strain BTZ plasmid pBTZ_1, complete sequence	14219-14248	9	0.7
NZ_ALTB01000020_1	1.4\|120961\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	120961-120990	30	NC_011316	Aliivibrio salmonicida LFI1238 plasmid pVSAL43, complete sequence	3491-3520	9	0.7
NZ_ALTB01000020_1	1.9\|121291\|30\|NZ_ALTB01000020\|CRISPRCasFinder,CRT,PILER-CR	121291-121320	30	MK249142	Blackfly microvirus SF02 isolate 030, complete genome	4552-4581	9	0.7

1. spacer 1.1|120763|30|NZ_ALTB01000020|CRISPRCasFinder,CRT matches to MK448971 (Streptococcus phage Javan52, complete genome) position: , mismatch: 0, identity: 1.0

taattaaaaacaaaaagccccaaaacctgt	CRISPR spacer
taattaaaaacaaaaagccccaaaacctgt	Protospacer
******************************

2. spacer 1.1|120763|30|NZ_ALTB01000020|CRISPRCasFinder,CRT matches to MK448956 (Streptococcus phage Javan48, complete genome) position: , mismatch: 0, identity: 1.0

taattaaaaacaaaaagccccaaaacctgt	CRISPR spacer
taattaaaaacaaaaagccccaaaacctgt	Protospacer
******************************

3. spacer 1.3|120895|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448708 (Streptococcus phage Javan23, complete genome) position: , mismatch: 0, identity: 1.0

tttattacacgcttgttgaatttcacgagt	CRISPR spacer
tttattacacgcttgttgaatttcacgagt	Protospacer
******************************

4. spacer 1.3|120895|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448897 (Streptococcus phage Javan28, complete genome) position: , mismatch: 0, identity: 1.0

tttattacacgcttgttgaatttcacgagt	CRISPR spacer
tttattacacgcttgttgaatttcacgagt	Protospacer
******************************

5. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448708 (Streptococcus phage Javan23, complete genome) position: , mismatch: 0, identity: 1.0

tccatataatgctaactcagcatcattctc	CRISPR spacer
tccatataatgctaactcagcatcattctc	Protospacer
******************************

6. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448897 (Streptococcus phage Javan28, complete genome) position: , mismatch: 0, identity: 1.0

tccatataatgctaactcagcatcattctc	CRISPR spacer
tccatataatgctaactcagcatcattctc	Protospacer
******************************

7. spacer 1.7|121159|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448708 (Streptococcus phage Javan23, complete genome) position: , mismatch: 1, identity: 0.967

ggagaaccttgacatcattgctaaacgcac	CRISPR spacer
ggagaaccttgacatcattgctaagcgcac	Protospacer
************************.*****

8. spacer 1.7|121159|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448897 (Streptococcus phage Javan28, complete genome) position: , mismatch: 1, identity: 0.967

ggagaaccttgacatcattgctaaacgcac	CRISPR spacer
ggagaaccttgacatcattgctaagcgcac	Protospacer
************************.*****

9. spacer 1.1|120763|30|NZ_ALTB01000020|CRISPRCasFinder,CRT matches to MK448851 (Streptococcus phage Javan14, complete genome) position: , mismatch: 2, identity: 0.933

taattaaaaacaaaaagccccaaaacctgt	CRISPR spacer
taattaaaaacaaaaagccccaaatccttt	Protospacer
************************ *** *

10. spacer 1.8|121225|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448925 (Streptococcus phage Javan386, complete genome) position: , mismatch: 2, identity: 0.933

aatcagagctttacaacgcaattgttgata	CRISPR spacer
aatctgagctttacaatgcaattgttgata	Protospacer
**** ***********.*************

11. spacer 1.8|121225|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448927 (Streptococcus phage Javan394, complete genome) position: , mismatch: 2, identity: 0.933

aatcagagctttacaacgcaattgttgata	CRISPR spacer
aatctgagctttacaatgcaattgttgata	Protospacer
**** ***********.*************

12. spacer 1.8|121225|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448905 (Streptococcus phage Javan318, complete genome) position: , mismatch: 4, identity: 0.867

aatcagagctttacaacgcaattgttgata	CRISPR spacer
gctcagaactttacaacgccattgttgata	Protospacer
. *****.*********** **********

13. spacer 1.6|121093|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448738 (Streptococcus phage Javan355, complete genome) position: , mismatch: 5, identity: 0.833

tcgtagtatgtcgcttttggttgcaactcc	CRISPR spacer
tcgtagtatgttgcttttggttgtagttct	Protospacer
***********.***********.*..**.

14. spacer 1.8|121225|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448834 (Streptococcus phage Javan91, complete genome) position: , mismatch: 5, identity: 0.833

aatcagagctttacaacgcaattgttgata	CRISPR spacer
gaccagagctttacaatgcaattattgaca	Protospacer
.*.*************.******.****.*

15. spacer 1.8|121225|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK449009 (Streptococcus phage Javan88, complete genome) position: , mismatch: 5, identity: 0.833

aatcagagctttacaacgcaattgttgata	CRISPR spacer
gaccagagctttacaatgcaattattgaca	Protospacer
.*.*************.******.****.*

16. spacer 1.1|120763|30|NZ_ALTB01000020|CRISPRCasFinder,CRT matches to MT773557 (Myoviridae sp. isolate BML_S_1 genomic sequence) position: , mismatch: 6, identity: 0.8

taattaaaaacaaaaagccccaaaacctgt	CRISPR spacer
taattaaaaacaaaaaggcgcaaaatggct	Protospacer
***************** * *****.   *

17. spacer 1.9|121291|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to KJ018210 (Flavobacterium sp. phage 1/32, complete genome) position: , mismatch: 6, identity: 0.8

gtaaaaacttgtgttttttttgtgtttgaa	CRISPR spacer
aaaaaaacttgtcttttttttgtgttatat	Protospacer
. ********** *************  *

18. spacer 1.9|121291|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MN698242 (Pelagibacter phage HTVC103P, complete genome) position: , mismatch: 6, identity: 0.8

gtaaaaacttgtgttttttttgtgtttgaa	CRISPR spacer
gttatgccttatgttttttttgtatttgaa	Protospacer
** * . ***.************.******

19. spacer 1.11|121423|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NC_047897 (Lactobacillus phage Lenus, complete genome) position: , mismatch: 6, identity: 0.8

tggttatacatttactaatccatcagcatt	CRISPR spacer
ggatggtactgttactaatccatcagcatt	Protospacer
 *.* .***  *******************

20. spacer 1.11|121423|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to AP013698 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C55A-MedDCM-OCT-S36-C68, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.8

-tggttatacatttactaatccatcagcatt	CRISPR spacer
ctcagta-acagttactaatacatcagcatt	Protospacer
 * . ** *** ******** **********

21. spacer 1.2|120829|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NC_015937 (Thermus phage TMA, complete genome) position: , mismatch: 7, identity: 0.767

----atttgacaaacattgaacttaaaagaaact	CRISPR spacer
cagaat----aaaacattaaactcaaaagaaact	Protospacer
    **     *******.****.**********

22. spacer 1.2|120829|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MH595538 (Vibrio phage BONAISHI, complete genome) position: , mismatch: 7, identity: 0.767

atttgacaaacattgaacttaaaagaaact	CRISPR spacer
ttaaggcaaacattgaacataaaggaaaca	Protospacer
 *  *.************ ****.*****

23. spacer 1.2|120829|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to AP011617 (Thermus phage TMA DNA, complete genome) position: , mismatch: 7, identity: 0.767

----atttgacaaacattgaacttaaaagaaact	CRISPR spacer
cagaat----aaaacattaaactcaaaagaaact	Protospacer
    **     *******.****.**********

24. spacer 1.5|121027|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP046475 (Janibacter melonis strain M714 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

aggtgcactcgcaccattgca-aacactgga	CRISPR spacer
aggtgcactcgcaccatggcagggcatttc-	Protospacer
***************** *** ..**.*

25. spacer 1.8|121225|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK448878 (Streptococcus phage Javan224, complete genome) position: , mismatch: 7, identity: 0.767

aatcagagctttacaacgcaattgttgata	CRISPR spacer
gtcctgaactttacaacgcaattattgaca	Protospacer
. .* **.***************.****.*

26. spacer 1.9|121291|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP009417 (Jeotgalibacillus malaysiensis strain malaysiensis plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

gtaaaaacttgtgttttttttgtgtttgaa	CRISPR spacer
tcacgatgttgtgttttttttgtgtttgac	Protospacer
 .* .*  *********************

27. spacer 1.11|121423|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NC_047925 (Lactobacillus phage Nyseid, complete genome) position: , mismatch: 7, identity: 0.767

tggttatacatttactaatccatcagcatt	CRISPR spacer
ggacggtactgttactaatccatcagcatt	Protospacer
 *.. .***  *******************

28. spacer 1.11|121423|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to KU052488 (Lactobacillus phage SA-C12, complete genome) position: , mismatch: 7, identity: 0.767

tggttatacatttactaatccatcagcatt	CRISPR spacer
ggacggtactgttactaatccatcagcatt	Protospacer
 *.. .***  *******************

29. spacer 1.11|121423|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MN693473 (Marine virus AFVG_25M504, complete genome) position: , mismatch: 7, identity: 0.767

tggttatacatttactaatccatcagcatt	CRISPR spacer
tggtgatacatttactaatcctatgccatc	Protospacer
**** ****************  .. ***.

30. spacer 1.1|120763|30|NZ_ALTB01000020|CRISPRCasFinder,CRT matches to MN693770 (Marine virus AFVG_250M115, complete genome) position: , mismatch: 8, identity: 0.733

taattaaaaacaaaaagccccaaaacctgt	CRISPR spacer
caaataaaaagaaaaagccccaaaaataaa	Protospacer
.** ****** ************** . .

31. spacer 1.1|120763|30|NZ_ALTB01000020|CRISPRCasFinder,CRT matches to MN693770 (Marine virus AFVG_250M115, complete genome) position: , mismatch: 8, identity: 0.733

taattaaaaacaaaaagccccaaaacctgt	CRISPR spacer
caaataaaaagaaaaagccccaaaaataaa	Protospacer
.** ****** ************** . .

32. spacer 1.1|120763|30|NZ_ALTB01000020|CRISPRCasFinder,CRT matches to NZ_CP021457 (Lactobacillus brevis strain ZLB004 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.733

taattaaaaacaaaaagccccaaaacctgt	CRISPR spacer
ccattgaaaacaaaaagccccacaattgga	Protospacer
. ***.**************** **.. *

33. spacer 1.1|120763|30|NZ_ALTB01000020|CRISPRCasFinder,CRT matches to NZ_CP040048 (Acinetobacter baumannii strain VB1190 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

taattaaaaacaaaaagccccaaaacctgt	CRISPR spacer
atcttaaaaacaaaaaaccccgaaactttc	Protospacer
   *************.****.****.* .

34. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to HG983280 (Aliivibrio salmonicida plasmid pVSAL68, strain Vs289, complete sequence) position: , mismatch: 8, identity: 0.733

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcta	Protospacer
 * .  .*************** ******

35. spacer 1.7|121159|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MF042360 (Pseudomonas phage Phabio, complete genome) position: , mismatch: 8, identity: 0.733

ggagaaccttgacatcattgctaaacgcac	CRISPR spacer
agagaaccttcacagcattgctaagccgtt	Protospacer
.********* *** *********.*   .

36. spacer 1.9|121291|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to AP014379 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-U-MedDCM-OCT-S43-C51, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 8, identity: 0.733

gtaaaaacttgtgttttttttgtgtttgaa	CRISPR spacer
tataaaacttgtatcttttttgtgttctat	Protospacer
   *********.*.***********. *

37. spacer 1.9|121291|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MN850656 (Flavobacterium phage fF4, complete genome) position: , mismatch: 8, identity: 0.733

gtaaaaacttgtgttttttttgtgtttgaa	CRISPR spacer
acagaaagttttgttttttttgtgttttgc	Protospacer
..*.*** ** **************** .

38. spacer 1.11|121423|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to AP018932 (Escherichia phage KIT03 DNA, complete sequence) position: , mismatch: 8, identity: 0.733

tggttatacatttactaatccatcagcatt	CRISPR spacer
gggtaatacatttactaatccaagcgaagg	Protospacer
 *** *****************   * *

39. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to HG983279 (Aliivibrio salmonicida plasmid pVSAL111, strain TEO83.001, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcaa	Protospacer
 * .  .*************** *****

40. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to HG983279 (Aliivibrio salmonicida plasmid pVSAL111, strain TEO83.001, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcaa	Protospacer
 * .  .*************** *****

41. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NC_011314 (Aliivibrio salmonicida LFI1238 plasmid pVSAL320, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcaa	Protospacer
 * .  .*************** *****

42. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NC_011314 (Aliivibrio salmonicida LFI1238 plasmid pVSAL320, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcaa	Protospacer
 * .  .*************** *****

43. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NC_011314 (Aliivibrio salmonicida LFI1238 plasmid pVSAL320, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcaa	Protospacer
 * .  .*************** *****

44. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP034239 (Aliivibrio salmonicida strain VS224 plasmid pVS320-224, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcaa	Protospacer
 * .  .*************** *****

45. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP034239 (Aliivibrio salmonicida strain VS224 plasmid pVS320-224, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcaa	Protospacer
 * .  .*************** *****

46. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP034239 (Aliivibrio salmonicida strain VS224 plasmid pVS320-224, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcaa	Protospacer
 * .  .*************** *****

47. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP034239 (Aliivibrio salmonicida strain VS224 plasmid pVS320-224, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcaa	Protospacer
 * .  .*************** *****

48. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP007625 (Bacillus pseudomycoides strain 219298 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
cttatataaagctatctcagcatcatcaaa	Protospacer
...****** **** ***********.

49. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP009650 (Bacillus pseudomycoides strain BTZ plasmid pBTZ_1, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
cttatataaagctatctcagcatcatcaaa	Protospacer
...****** **** ***********.

50. spacer 1.4|120961|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to NC_011316 (Aliivibrio salmonicida LFI1238 plasmid pVSAL43, complete sequence) position: , mismatch: 9, identity: 0.7

tccatataatgctaactcagcatcattctc	CRISPR spacer
acgggccaatgctaactcagcaacattcaa	Protospacer
 * .  .*************** *****

51. spacer 1.9|121291|30|NZ_ALTB01000020|CRISPRCasFinder,CRT,PILER-CR matches to MK249142 (Blackfly microvirus SF02 isolate 030, complete genome) position: , mismatch: 9, identity: 0.7

gtaaaaacttgtgttttttttgtgtttgaa	CRISPR spacer
tttcttacttgtgttttttttgtatttttg	Protospacer
 *    *****************.***  .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

7. NZ_ALTB01000021

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

92 : 77636

Streptococcus_phage(85.96%)

integrase,holin,protease,head,transposase,tail,terminase,portal,tRNA

attL 45662:45682|attR 77688:77708

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000160532.1\|92_1259_+\|transposase	IS30-like element ISSag9 family transposase	NA	NA	NA	NA
WP_000429363.1\|1657_3385_-	ABC transporter permease/substrate binding protein	NA	NA	NA	NA
WP_000181803.1\|3403_4627_-	glycine betaine/L-proline ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.6e-29	37.0
WP_001865940.1\|4769_4889_+	hypothetical protein	NA	NA	NA	NA
WP_001288397.1\|5003_7382_-	phosphoketolase family protein	NA	NA	NA	NA
WP_001134214.1\|7471_8563_-	L-ascorbate 6-phosphate lactonase	NA	NA	NA	NA
WP_000584681.1\|8879_10559_-	transcription antiterminator	NA	NA	NA	NA
WP_000806822.1\|10624_11386_-	hypothetical protein	NA	NA	NA	NA
WP_000222918.1\|11405_12923_-	carbohydrate kinase	NA	NA	NA	NA
WP_000717730.1\|12988_13978_-	amidohydrolase	NA	NA	NA	NA
WP_000888344.1\|13999_15451_-	PTS galactitol transporter subunit IIC	NA	NA	NA	NA
WP_000358398.1\|15548_16505_-	dihydrofolate reductase	M1I4S0	Paramecium_bursaria_Chlorella_virus	9.3e-30	30.9
WP_000700534.1\|16523_17543_-	hypothetical protein	NA	NA	NA	NA
WP_000462134.1\|17777_18761_-	LacI family DNA-binding transcriptional regulator	NA	NA	NA	NA
WP_000873297.1\|18924_19572_-	fructose-6-phosphate aldolase	M4SIN4	Cyanophage	4.5e-44	43.5
WP_001129982.1\|19582_20299_-	L-ribulose-5-phosphate 4-epimerase	NA	NA	NA	NA
WP_000197821.1\|20300_21164_-	L-ribulose-5-phosphate 3-epimerase	NA	NA	NA	NA
WP_000166859.1\|21167_21833_-	3-keto-L-gulonate-6-phosphate decarboxylase UlaD	NA	NA	NA	NA
WP_001049921.1\|21945_22431_-	PTS transporter subunit EIIA	NA	NA	NA	NA
WP_000241475.1\|22497_22776_-	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_000427087.1\|22803_24243_-	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_001224528.1\|24410_25028_-	hypothetical protein	NA	NA	NA	NA
WP_011058371.1\|25186_25660_+	hypothetical protein	NA	NA	NA	NA
WP_000205037.1\|25682_26975_-	adenylosuccinate synthase	G5CQQ4	Megavirus	5.1e-71	36.7
WP_001021300.1\|27345_28368_-	PTS sugar transporter subunit IIC	NA	NA	NA	NA
WP_000356661.1\|28729_29404_+	DNA-binding protein	NA	NA	NA	NA
WP_000582678.1\|29573_31826_+	bifunctional glutamate--cysteine ligase GshA/glutathione synthetase GshB	NA	NA	NA	NA
WP_000239572.1\|31949_32768_+	hypothetical protein	M1PFV6	Streptococcus_phage	4.4e-28	36.0
WP_001285393.1\|32764_34021_+	hypothetical protein	M1PLC8	Streptococcus_phage	2.5e-123	63.3
WP_000357824.1\|34160_35036_+	Hsp33 family molecular chaperone HslO	NA	NA	NA	NA
WP_000192736.1\|35019_35997_+\|tRNA	tRNA dihydrouridine synthase DusB	NA	NA	NA	NA
WP_000909526.1\|36117_36759_+	deoxynucleoside kinase	A0A0M3UL55	Enterococcus_phage	1.3e-46	47.8
WP_000586895.1\|36772_37264_+	N-acetyltransferase	A0A2H4J136	uncultured_Caudovirales_phage	2.6e-28	40.8
WP_000020289.1\|37483_39931_-\|protease	ATP-dependent Clp protease ATP-binding subunit	H6X3M6	Enterobacteria_phage	1.5e-124	38.4
WP_000985641.1\|39927_40392_-	CtsR family transcriptional regulator	NA	NA	NA	NA
WP_001106578.1\|40564_41026_+	small multi-drug export protein	NA	NA	NA	NA
WP_000808080.1\|41184_42225_-	elongation factor Ts	NA	NA	NA	NA
WP_000268454.1\|42318_43089_-	30S ribosomal protein S2	NA	NA	NA	NA
WP_000060540.1\|43365_43926_+	peroxiredoxin	NA	NA	NA	NA
WP_000242129.1\|43943_45476_+	alkyl hydroperoxide reductase subunit F	A0A2I2L5E1	Orpheovirus	8.5e-41	35.4
45662:45682	attL	NA	NA	NA	NA
WP_000878126.1\|45894_46299_-	HicB family protein	A0A1P8VVW2	Streptococcus_phage	1.4e-67	100.0
WP_000139836.1\|46359_46545_-	type II toxin-antitoxin system HicA family toxin	A0A1P8VVU8	Streptococcus_phage	2.6e-29	100.0
WP_000405192.1\|46751_48158_-	muramidase	A0A1P8VVS3	Streptococcus_phage	6.9e-231	100.0
WP_000192161.1\|48161_48491_-\|holin	phage holin	A0A1P8VVR0	Streptococcus_phage	4.8e-50	100.0
WP_001135353.1\|48493_48904_-	hypothetical protein	A0A1P8VVS2	Streptococcus_phage	2.0e-69	100.0
WP_000213866.1\|48938_49277_-	hypothetical protein	A0A1P8VVU3	Streptococcus_phage	4.3e-62	100.0
WP_001071121.1\|49279_49510_-	hypothetical protein	A0A1P8VVV7	Streptococcus_phage	2.9e-30	100.0
WP_001895725.1\|49526_53201_-	hypothetical protein	A0A1P8VVT1	Streptococcus_phage	0.0e+00	100.0
WP_000161557.1\|53201_53924_-	hypothetical protein	A0A1P8VVR4	Streptococcus_phage	2.8e-135	100.0
WP_000140779.1\|53920_56656_-\|tail	phage tail tape measure protein	A0A1P8VVW8	Streptococcus_phage	7.3e-269	100.0
WP_011058372.1\|56674_56803_-	hypothetical protein	A0A0A0YRS9	Streptococcus_phage	1.6e-14	90.5
WP_000591558.1\|56841_57318_-	hypothetical protein	A0A1P8VVU0	Streptococcus_phage	9.2e-87	100.0
WP_000222195.1\|57317_58001_-	hypothetical protein	A0A1P8VVR1	Streptococcus_phage	9.1e-128	100.0
WP_000508738.1\|58015_58360_-	hypothetical protein	A0A1P8VVU6	Streptococcus_phage	1.5e-59	100.0
WP_001074486.1\|58346_58694_-	hypothetical protein	A0A1P8VVS6	Streptococcus_phage	1.1e-60	100.0
WP_000842789.1\|58693_58999_-\|head,tail	head-tail adaptor protein	A0A1P8VVX4	Streptococcus_phage	5.8e-42	100.0
WP_000153862.1\|58995_59331_-	hypothetical protein	A0A1P8VVS7	Streptococcus_phage	7.0e-57	100.0
WP_000749070.1\|59351_60614_-	hypothetical protein	A0A1P8VVT0	Streptococcus_phage	2.6e-229	100.0
WP_000413200.1\|60624_61167_-\|head,protease	HK97 family phage prohead protease	A0A1P8VVX2	Streptococcus_phage	2.7e-98	100.0
WP_001067328.1\|61216_62359_-\|portal	phage portal protein	A0A1P8VVT4	Streptococcus_phage	6.6e-216	100.0
WP_000230004.1\|62367_64080_-\|terminase	terminase large subunit	A0A1P8VVW5	Streptococcus_phage	0.0e+00	100.0
WP_000601035.1\|64072_64558_-	hypothetical protein	A0A1P8VVU4	Streptococcus_phage	1.9e-79	99.4
WP_000542279.1\|64645_65005_-	HNH endonuclease	A0A1P8VVU5	Streptococcus_phage	6.3e-64	100.0
WP_000651009.1\|65004_65292_-	hypothetical protein	A0A1P8VVZ1	Streptococcus_phage	3.6e-46	100.0
WP_001028147.1\|65581_66124_-\|integrase	site-specific integrase	A0A1S5SCL7	Streptococcus_phage	9.8e-101	100.0
WP_000163169.1\|66233_66698_-	hypothetical protein	A0A1P8VVT5	Streptococcus_phage	1.8e-82	100.0
WP_011058373.1\|66694_67054_-	helix-turn-helix transcriptional regulator	A0A1P8VVV5	Streptococcus_phage	4.1e-63	100.0
WP_001008140.1\|67038_67299_-	hypothetical protein	A0A1P8VVV2	Streptococcus_phage	9.9e-43	100.0
WP_000609565.1\|67308_67725_-	single-stranded DNA-binding protein	A0A1P8VVS8	Streptococcus_phage	8.6e-73	100.0
WP_000748199.1\|67714_67921_-	hypothetical protein	A0A1P8VVV0	Streptococcus_phage	6.2e-32	100.0
WP_000158822.1\|67917_68274_-	DUF3310 domain-containing protein	M1NRN1	Streptococcus_phage	6.5e-37	69.0
WP_000793494.1\|68273_68603_-	DUF1372 family protein	A0A1P8VVQ5	Streptococcus_phage	1.1e-54	94.5
WP_000169322.1\|68602_69094_-	hypothetical protein	A0A1P8VVP1	Streptococcus_phage	4.9e-83	95.7
WP_153204894.1\|69086_69242_-	hypothetical protein	NA	NA	NA	NA
WP_001067867.1\|69284_70106_-	ATP-binding protein	A0A1P8VVV9	Streptococcus_phage	2.9e-144	92.3
WP_000079054.1\|70106_70853_-	hypothetical protein	A0A1P8VVR3	Streptococcus_phage	1.5e-136	98.4
WP_000988139.1\|70830_71436_-	hypothetical protein	A0A1P8VVT8	Streptococcus_phage	3.8e-69	64.0
WP_000343908.1\|71435_72767_-	replicative DNA helicase	A0A1P8VVQ6	Streptococcus_phage	7.7e-240	98.0
WP_001061697.1\|72775_72991_-	hypothetical protein	C5J986	Streptococcus_phage	6.1e-14	62.0
WP_000998973.1\|73007_73292_-	hypothetical protein	A0A1P8VVZ3	Streptococcus_phage	2.5e-47	93.6
WP_001002368.1\|73351_74062_-	hypothetical protein	A0A1S5SF52	Streptococcus_phage	3.5e-114	82.1
WP_011058376.1\|74064_74373_-	helix-turn-helix transcriptional regulator	A0A1P8VVQ4	Streptococcus_phage	4.8e-28	91.3
WP_001052630.1\|74334_74805_+	hypothetical protein	A0A1P8VVS1	Streptococcus_phage	8.8e-82	98.7
WP_000511144.1\|74787_74952_-	hypothetical protein	A0A1P8VVU2	Streptococcus_phage	1.8e-21	100.0
WP_011058377.1\|74933_75089_-	hypothetical protein	NA	NA	NA	NA
WP_000114553.1\|75237_75600_+	helix-turn-helix transcriptional regulator	A0A1P8VVY1	Streptococcus_phage	3.0e-61	100.0
WP_001132094.1\|75600_75987_+	ImmA/IrrE family metallo-endopeptidase	A0A1P8VVS0	Streptococcus_phage	4.5e-68	100.0
WP_001173134.1\|76039_76444_+	DUF4429 domain-containing protein	A0A1P8VVY3	Streptococcus_phage	8.1e-68	100.0
WP_000179397.1\|76565_77636_+\|integrase	site-specific integrase	A0A1P8VVR7	Streptococcus_phage	2.1e-200	100.0
77688:77708	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

8. NZ_ALTB01000027

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

38487 : 46041

Streptococcus_phage(50.0%)

integrase,transposase

attL 31832:31847|attR 49321:49336

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
31832:31847	attL	NA	NA	NA	NA
WP_000595708.1\|38487_39684_+	voltage-gated chloride channel family protein	A0A1X9I5Z9	Streptococcus_phage	4.6e-103	54.5
WP_001068667.1\|40263_40611_+	50S ribosomal protein L19	NA	NA	NA	NA
WP_071659971.1\|40755_41370_-\|integrase	site-specific integrase	F8HGP4	Streptococcus_phage	9.2e-55	60.7
WP_001872365.1\|41372_41639_-	hypothetical protein	Q77YW7	Streptococcus_phage	9.2e-20	65.2
WP_000640620.1\|41638_42043_+	helix-turn-helix domain-containing protein	A0A0C5AJ29	Paenibacillus_phage	1.3e-20	43.6
WP_001122304.1\|42204_42405_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_001865698.1\|42426_42687_+\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	3.4e-11	43.0
WP_001867107.1\|42812_43022_+\|transposase	transposase	NA	NA	NA	NA
WP_000508795.1\|43194_43356_-	TM2 domain-containing protein	NA	NA	NA	NA
WP_000594360.1\|44097_45375_+	ABC transporter permease	NA	NA	NA	NA
WP_000353149.1\|45384_46041_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.2e-22	31.8
49321:49336	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

9. NZ_ALTB01000005

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr_ID: NZ_ALTB01000005.1|WP_000384271.1|62764_63091_+|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_ALTB01000005.1|WP_000384271.1|62764_63091_+|hypothetical-protein

62764_63091_+

108 aa aa

AcrIIA21

hit_Aca_id	identity	query_coverage	hit_coverage
anti_CRISPR3639\|WP_000384271.1\|AcrIIA21\|II-A\|Verified\|Streptococcus	1.0	1	1.0

HTH_XRE

Identity	Hit_domain_coverage
NA	NA

10. NZ_ALTB01000006

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

40173 : 49558

uncultured_Caudovirales_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000120355.1\|40173_40875_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	9.2e-35	39.9
WP_000246611.1\|41011_43132_-	type I DNA topoisomerase	E3T4K4	Cafeteria_roenbergensis_virus	1.1e-102	37.7
WP_001015250.1\|43226_44069_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	8.5e-27	35.8
WP_000162771.1\|44206_45235_-	siderophore ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000614752.1\|45296_46058_-	ATP-binding cassette domain-containing protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	1.7e-18	28.6
WP_000588576.1\|46054_47029_-	iron chelate uptake ABC transporter family permease subunit	A0A2H4IY97	uncultured_Caudovirales_phage	3.6e-05	21.2
WP_000735588.1\|47025_47988_-	iron chelate uptake ABC transporter family permease subunit	A0A2H4IY97	uncultured_Caudovirales_phage	3.3e-83	50.3
WP_000136508.1\|48185_48776_-	sugar O-acetyltransferase	NA	NA	NA	NA
WP_000201088.1\|48796_49558_-	ribonuclease HII	D2TEQ2	Emiliania_huxleyi_virus	1.5e-25	40.7

DBSCAN-SWA_2

102035 : 111028

Bacillus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000222543.1\|102035_103754_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	1.8e-278	84.8
WP_000746858.1\|103777_104017_-	hypothetical protein	NA	NA	NA	NA
WP_000647638.1\|104030_105764_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	5.1e-50	31.0
WP_000826946.1\|105764_107486_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.8e-40	26.7
WP_000472259.1\|107497_108100_-	lysozyme family protein	A0A223LKM8	Bacillus_phage	1.1e-20	40.1
WP_000968655.1\|108101_109079_-	nucleoid-associated protein	NA	NA	NA	NA
WP_000575545.1\|109083_110340_-	serine hydroxymethyltransferase	A0A240F3L3	Aeromonas_phage	7.8e-93	51.7
WP_000998735.1\|110431_111028_-	threonylcarbamoyl-AMP synthase	A0A291ATS8	Pandoravirus	1.1e-15	29.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

11. NZ_ALTB01000010

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

48589 : 58861

Streptococcus_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000721255.1\|48589_50734_-	LTA synthase family protein	W6LM83	Streptococcus_phage	1.4e-259	67.4
WP_001037599.1\|50868_52026_+	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	6.0e-140	65.7
WP_000707048.1\|52025_52703_+	type I 3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	5.3e-88	68.4
WP_001195725.1\|52796_53864_+	3-dehydroquinate synthase	NA	NA	NA	NA
WP_001269904.1\|53864_55031_+	chorismate synthase	A0A291AU41	Pandoravirus	7.1e-40	34.4
WP_000024629.1\|55114_55450_+	YlbF/YmcA family competence regulator	A0A1X9I5Y8	Streptococcus_phage	1.5e-19	39.4
WP_000043882.1\|55624_56974_+	glutathione-disulfide reductase	A0A2K5B2C5	Erysipelothrix_phage	1.4e-31	25.3
WP_000033715.1\|57016_57469_-	hypothetical protein	NA	NA	NA	NA
WP_000638895.1\|57715_58861_+	cysteine desulfurase	A0A1X6WFP1	Pacmanvirus	9.5e-29	28.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

12. NZ_ALTB01000018

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

38699 : 47189

Streptococcus_phage(100.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000767484.1\|38699_39527_+	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	4.3e-124	78.0
WP_000287944.1\|39566_39923_-	arsenate reductase family protein	M1PLC0	Streptococcus_phage	1.5e-41	71.8
WP_000966773.1\|39924_40401_-	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	1.0e-37	50.3
WP_000232156.1\|40455_41637_-	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	7.0e-168	75.6
WP_001167085.1\|41699_42248_-	acetyltransferase	M1PSC3	Streptococcus_phage	1.1e-54	58.4
WP_000603277.1\|43540_44176_+	copper homeostasis protein CutC	NA	NA	NA	NA
WP_011058365.1\|44219_44324_-	hypothetical protein	NA	NA	NA	NA
WP_011058366.1\|44308_44470_+	hypothetical protein	NA	NA	NA	NA
WP_001866320.1\|44445_45309_-	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	3.7e-110	70.4
WP_000358198.1\|45314_45641_-	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	3.2e-30	61.1
WP_000364565.1\|45670_46534_-	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	7.3e-74	49.7
WP_000715592.1\|46553_47189_-	dTMP kinase	M1PSC7	Streptococcus_phage	2.8e-67	61.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage