CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_KE159705	Oscillibacter sp. 1-3 acPPL-supercont1.11, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_KE159709	Oscillibacter sp. 1-3 acPPL-supercont1.4, whole genome shotgun sequence	2 crisprs	DEDDh,RT,WYL,cas14j,c2c9_V-U4	1	0	2	0
NZ_KE159712	Oscillibacter sp. 1-3 acPPL-supercont1.7, whole genome shotgun sequence	2 crisprs	cas14j	1	0	0	0
NZ_KE159706	Oscillibacter sp. 1-3 acPPL-supercont1.12, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_KE159713	Oscillibacter sp. 1-3 acPPL-supercont1.8, whole genome shotgun sequence	0 crisprs	WYL	0	0	0	0
NZ_KE159711	Oscillibacter sp. 1-3 acPPL-supercont1.6, whole genome shotgun sequence	2 crisprs	cas3,cas5,cas8c,cas7,cas4,cas1,cas2,WYL	0	7	4	0
NZ_KE159704	Oscillibacter sp. 1-3 acPPL-supercont1.10, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_KE159707	Oscillibacter sp. 1-3 acPPL-supercont1.2, whole genome shotgun sequence	3 crisprs	DinG,cas14j,RT,WYL	1	0	2	1
NZ_KE159714	Oscillibacter sp. 1-3 acPPL-supercont1.9, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_KE159703	Oscillibacter sp. 1-3 acPPL-supercont1.1, whole genome shotgun sequence	2 crisprs	RT,DinG,csa3	3	0	3	0
NZ_KE159708	Oscillibacter sp. 1-3 acPPL-supercont1.3, whole genome shotgun sequence	0 crisprs	csa3,RT	0	0	1	0
NZ_KE159710	Oscillibacter sp. 1-3 acPPL-supercont1.5, whole genome shotgun sequence	0 crisprs	DEDDh,RT	0	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_KE159707_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159707_2

276276-276418

Orphan

Consensus_repeat	Method
TCATCAGCCTTACCGGGAGCGGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_KE159707_2

>merge|NZ_KE159707|2|276276-276418|CRISPRCasFinder
TCGTCAGCCTTACCGGGAGCGGCGGCACCTGCCGCCTTGGTCTGCTCCGGCGGCTTCTTCTCGTCAGCCTTACCGGGAGCGGCGGCACCTGCCGTCTTGGTCTGCTCCGGCGGCTTCTTCTCGTCGGCCTTGCCAGGGGCAGC

>NZ_KE159707|2|2|276276-276418|CRISPRCasFinder
TCGTCAGCCTTACCGGGAGCGGC	GGCACCTGCCGCCTTGGTCTGCTCCGGCGGCTTCTTC
TCGTCAGCCTTACCGGGAGCGGC	GGCACCTGCCGTCTTGGTCTGCTCCGGCGGCTTCTTC
TCGTCGGCCTTGCCAGGGGCAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159707.1\|WP_016321836.1\|276630_277596_-\|replication-initiator-protein-A	unknown	unknown	gnl\|CDD\|369151
NZ_KE159707.1\|WP_016321832.1\|273294_274233_-\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NZ_KE159707.1\|WP_016321834.1\|274581_276094_-\|ParB/RepB/Spo0J-family-partition-protein	unknown	unknown	gnl\|CDD\|319264
NZ_KE159707.1\|WP_016321833.1\|274290_274575_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321838.1\|279085_279916_-\|delta-lactam-biosynthetic-de-N-acetylase	unknown	unknown	gnl\|CDD\|131930
NZ_KE159707.1\|WP_016321837.1\|278683_279055_+\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NZ_KE159707.1\|WP_016321825.1\|267961_268360_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321827.1\|269504_270320_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376271
NZ_KE159707.1\|WP_016321828.1\|270332_271193_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376271
NZ_KE159707.1\|WP_016321841.1\|281707_282055_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321839.1\|280058_280631_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378379
NZ_KE159707.1\|WP_016321842.1\|282066_282465_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321831.1\|272224_273121_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376259
NZ_KE159707.1\|WP_016321840.1\|280634_281693_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377414
NZ_KE159707.1\|WP_016321830.1\|271614_272214_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321845.1\|284207_284792_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321826.1\|268423_269278_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321844.1\|283410_283980_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|131945
NZ_KE159707.1\|WP_016321829.1\|271205_271598_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376262
NZ_KE159707.1\|WP_016321843.1\|282469_283414_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_KE159707.1\|WP_016321836.1\|276630_277596_-\|replication-initiator-protein-A	gnl\|CDD\|369151	pfam06970, RepA_N, Replication initiator protein A (RepA) N-terminus. This of family of predicted proteins represents the N-terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids. Most proteins in this family are bacterial, but archaeal and eukaryotic members are also included.	2.71209e-32
NZ_KE159707.1\|WP_016321832.1\|273294_274233_-\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	0.00394482
NZ_KE159707.1\|WP_016321834.1\|274581_276094_-\|ParB/RepB/Spo0J-family-partition-protein	gnl\|CDD\|319264	cd16407, ParB_N_like, ParB N-terminal, parA-binding, -like domain of bacterial and plasmid parABS partitioning systems. This family represents the N-terminal domain of ParB, a DNA-binding component of the prokaryotic parABS partitioning system. parABS contributes to the efficient segregation of chromosomes and low-copy number plasmids to daughter cells during prokaryotic cell division. The process includes the parA (Walker box) ATPase, the ParB DNA-binding protein and a parS cis-acting DNA sites. Binding of ParB to centromere-like parS sites is followed by non-specific binding to DNA ("spreading", which has been implicated in gene silencing in plasmid P1) and oligomerization of additional ParB molecules near the parS sites. It has been proposed that ParB-ParB cross-linking compacts the DNA, binds to parA via the N-terminal region, and leads to parA separating the ParB-parS complexes and the recruitment of the SMC (structural maintenance of chromosomes) complexes. The ParB N-terminal domain of Bacillus subtilis and other species contains a Arginine-rich ParB Box II with residues essential for bridging of the ParB-parS complexes. The arginine-rich ParB Box II consensus (I[VIL]AGERR[FYW]RA[AS] identified in several species is partially conserved with this family and related families. Mutations within the basic columns particularly debilitate spreading from the parS sites and impair SMC recruitment. The C-terminal domain contains a HTH DNA-binding motif and is the primary homo-dimerization domain, and binds to parS DNA sites. Additional homo-dimerization contacts are found along the N-terminal domain, but dimerization of the N-terminus may only occur after concentration at ParB-parS foci.	2.04184e-45
NZ_KE159707.1\|WP_016321838.1\|279085_279916_-\|delta-lactam-biosynthetic-de-N-acetylase	gnl\|CDD\|131930	TIGR02884, spore_pdaA, delta-lactam-biosynthetic de-N-acetylase. Muramic delta-lactam is an unusual constituent of peptidoglycan, found only in bacterial spores in the peptidoglycan wall, or spore cortex. The proteins in this family are PdaA (yfjS), a member of a larger family of polysaccharide deacetylases, and are specificially involved in delta-lactam biosynthesis. PdaA acts immediately after CwlD, an N-acetylmuramoyl-L-alanine amidase and performs a de-N-acetylation. PdaA may also perform the following transpeptidation for lactam ring formation, as heterologous expression in E. coli of CwlD and PdaA together is sufficient for delta-lactam production. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination].	2.54176e-112
NZ_KE159707.1\|WP_016321840.1\|280634_281693_-\|hypothetical-protein	gnl\|CDD\|377414	pfam04865, Baseplate_J, Baseplate J-like protein. The P2 bacteriophage J protein lies at the edge of the baseplate. This family also includes a number of bacterial homologs, which are thought to have been horizontally transferred.	8.17267e-48
NZ_KE159707.1\|WP_016321827.1\|269504_270320_-\|hypothetical-protein	gnl\|CDD\|376271	pfam18852, LPD34, Large polyvalent protein associated domain 34. This is a predicted enzymatic alpha and beta fold domain with a large, prominent helix with conserved glutamate residue and several additional conserved residues including the motifs HTxN and SN. The domain is associated with polyvalent proteins of firmicute conjugative elements.	5.88791e-89
NZ_KE159707.1\|WP_016321828.1\|270332_271193_-\|hypothetical-protein	gnl\|CDD\|376271	pfam18852, LPD34, Large polyvalent protein associated domain 34. This is a predicted enzymatic alpha and beta fold domain with a large, prominent helix with conserved glutamate residue and several additional conserved residues including the motifs HTxN and SN. The domain is associated with polyvalent proteins of firmicute conjugative elements.	6.20936e-93
NZ_KE159707.1\|WP_016321839.1\|280058_280631_-\|hypothetical-protein	gnl\|CDD\|378379	pfam10076, DUF2313, Uncharacterized protein conserved in bacteria (DUF2313). Members of this family of proteins comprise various hypothetical and putative bacteriophage tail proteins.	0.000857249
NZ_KE159707.1\|WP_016321831.1\|272224_273121_-\|hypothetical-protein	gnl\|CDD\|376259	pfam18840, LPD25, Large polyvalent protein associated domain 25. This is an alpha and beta fold domain found in polyvalent proteins of conjugative elements.	3.7161e-20
NZ_KE159707.1\|WP_016321837.1\|278683_279055_+\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	3.60187e-26
NZ_KE159707.1\|WP_016321844.1\|283410_283980_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|131945	TIGR02899, hypothetical_conserved_protein, spore coat assembly protein SafA. SafA (YrbB) (SafA) of Bacillus subtilis is a protein found at the interface of the spore cortex and spore coat, and is dependent on SpoVID for its localization. This model is based on the N-terminal LysM (lysin motif) domain (see pfamAM model pfam01476) of SafA and, from several other spore-forming species, the protein with the most similar N-terminal region. However, this set of proteins differs greatly in C-terminal of the LysM domaim; blocks of 12-residue and 13-residue repeats are found in the Bacillus cereus group, tandem LysM domains in Thermoanaerobacter tengcongensis MB4, etc. in which one of which is found in most examples of endospore-forming bacteria. [Cellular processes, Sporulation and germination].	1.12191e-16
NZ_KE159707.1\|WP_016321829.1\|271205_271598_-\|hypothetical-protein	gnl\|CDD\|376262	pfam18843, LPD28, Large polyvalent protein associated domain 28. This is a beta strand rich domain that lacks strongly conserved polar residues. It is fast diverging and is found in polyvalent proteins of conjugative elements.	9.04934e-35

>NZ_KE159707.1|WP_016321834.1|274581_276094_-|ParB/RepB/Spo0J-family-partition-protein
AAAPGKADEKKPPEQIKAAGVAAPGKADEKKPPEQTKAADAAAPGKADEKSAEPTKDPNLRYVKISDIQPLPGTYVKDAPRADYSDLIDSIKKSGLEKPVILRQAEKGGYQLVDGFHRCEALKQAGVSEIRADVYDMTIFDASRYRKEHRANPDLSIPGTLVPLYPDTPSVEGRGSEAPETEDPPLEDVKIPLTPVGQPETVTELKITNIRSFEGHPFNVKDDEDMKSLVDSVRQFGVLEPVMVIPHKDGGYEMVSGHRRMRACQLVGIESIPVIIRNLDRDEAIISMVDSNLKREKISPMEKARAYQMKTDAMRRKVGRRSNAEILNGEAKPLNADQELAKQVGESVATIQRFKTLNKLTPELQEMVDQGKIPVNTGADIAQMKPAEQNILADAIKREDKVPTGAKAKELKEASKAGTLTEDKINQTVAPTKRELEPELKVTFSNEELRSYFPDKSTTVGEVKRVVFESLTMRQKALERRAREAAEKGKAPPPAKTSPSKTR
>NZ_KE159707.1|WP_016321833.1|274290_274575_-|hypothetical-protein
MKKQTIVGGYTIIERKQAGEVMVVVGHNPKASSPYVTWKAYDFTNFTSFNHGHYFLTRQEAMVDYFQRLAEVWEHYTPARHTPPKHRENDPPAK
>NZ_KE159707.1|WP_016321832.1|273294_274233_-|ImmA/IrrE-family-metallo-endopeptidase
MGKTLSPDQLKVWTDRLEAGVSELHDSQRYADYLSAMSKFHRYSYGNIILILQQCPHAQQVAGYHKWKNTFGRQVKRYETGITILAPCKYKCQVKAETAGGDEEPVQDTAVVEKCRFRTETVFDVSQTVGRELPSLGIAQLTGNVEGYDSLIGALKELSPVPVDTGVLRAGAYGCYSHVEERIIIQKDLTQVQTVKTLIHEIAHAKLHTLPVLNGVIMGSHQKGKSTREIEAESVAYVVCQYLGIDTSEYSLGYVAGWGRDREMRAFKSSLTCIRNTAAELIGGIESRCLKPEIERPAEEETRRQTDRTAVR
>NZ_KE159707.1|WP_016321831.1|272224_273121_-|hypothetical-protein
MENRLREIAGNLKQDVKDLLEESVNIVTGLIKQGVCTANGMTKRWNAFTNGLSQAAKALFEPFSYAPIVTENQQPLVTVRESTCEELPVGTRMTLAEAEERIEELNLSMIDSGGLIQDVKVTIDYRMDGEQDRYWLPLQIGSGQGSMLEQMEYIVRSCLHSPDSVTQDFYTASPGLGKLLHEHFGPQLHEDLEKLAERVLGYFQQHCTITRLEQQFALQAQVLPERDQQRFQESVKTAIAKFRRATNTGQAMEPVREQALPVHGDAQPRQSVKVKLHRIKDGRQKQPMLHKARNNPQR
>NZ_KE159707.1|WP_016321830.1|271614_272214_-|hypothetical-protein
MEKQIELIPFLERVVDQNTTHYKDDLQYDIIRFGEAVYKLEAEERAFYWMARPCGTQTVRERDAFLVGSDGHTIWTHYTYEAPKIQAYRIFVTGGTGGEPVGTVRRLDYPKQVRRVMANAIPAVRMELTFLSGEVREIALEDYPKEREWLFREYGMAKRVRYCPRDEDDLRFILTIEQRKQKRGRPRTAIKLNGSPVRE
>NZ_KE159707.1|WP_016321829.1|271205_271598_-|hypothetical-protein
MYSIDTVKERMETVEIFEIPGLFSVKRIDRVAIPKGMYAYDLQASKEDWGQPCRIGYQITERYFGTVLTASPVALPESGYCEAGPHDFIQGEKTERLTVAEFEAKYLSPNPEVQCRHRRWRRCFSSVSVR
>NZ_KE159707.1|WP_016321828.1|270332_271193_-|hypothetical-protein
MASQQPFYMVSSYTGNLREGQHIEVRRQILYQGENADFKPFAQFPVKELEKRLKKSLKAEKKIFNEMQRAIKAWDEHGAETLLLQKAIAYIKTPVVKHTGNEWKKRKDGAWEISNLVYHMMFKIEKHGDEWHLTWGLQYTAPALPKDYIPAPYNGWPKRRLEYESNKKYRTLDGAQKYIQAKFDQYATLFSELSPPVPEAVKRLFCVSGQLLPGYTLAEPERTEPDRKLVDELLNYLGEGDLDKSSPAQEERAPPVPEEQATPSPKPAHRTAKPQNRKKAKTNPVR
>NZ_KE159707.1|WP_016321827.1|269504_270320_-|hypothetical-protein
MSLNPGKELKLIYYAGLSLEKADLSDLAALTREELKTREQESVTKEEEVYGEIENLISEWARQAGETIRLRKTLEYLGVPAVRHTSNQWVKGDYDWYEMSNMVYKMTCRVSESTNWRSPQRPRPIYWELTWSLVFNTPQNPDYSGHGRQIAGQRQKRFDDKAALEKYLRGRIKAYAHLFTELSPPIPKEHCRRFCVNGLLLPGYAVDSPEVIAPDESAVEELLGFLNDGDLPGDSQETQIAQQPETSPEEIWSRHRKQRQETVQNKQAPTR
>NZ_KE159707.1|WP_016321826.1|268423_269278_-|hypothetical-protein
MLSWEPLNILSFGAGTPSTTLALMSCENALRGRPVWPHVPIYHAVIFCDLHGEPNWVYRQAAFVASACTAAGIPYYTLDANLYRDWTENFGRARVSSIPFWTLSADGKKGRMPRQCTYDYKIKRIEQFVRYELLCYRPKERALKIDIHAHTLHMGIMWEERHRAKESKQTLFVNRYPLIEMKWTRSACYTYNRDVWGLDTKASCCLFCPFHTNYFYRYIRQNEPACYNCALQVDRIAEIYQARPPVKSELFLSKSRKRLRDLNDADCNDVKYFWYKSFLVWDGF
>NZ_KE159707.1|WP_016321825.1|267961_268360_-|hypothetical-protein
MREPSFSPWGEIQSCDTLYPGIYLVTTPGHGGIIVEPTAALYLSSNARKCGFRDGGYLCFEEDCCEQVVLRELLDRGMWKLPERIKDKEGFEKEINRTIEKYHPNYWRARAAGKTVPRPVTCSRQRKEAPTR
>NZ_KE159707.1|WP_016321836.1|276630_277596_-|replication-initiator-protein-A
MAAKALYDYYYGDESSQFSFYRIPRQLITGDCFKRLSTDAKLLYGLLLDRMSLSAKNGWYDKQGRVYIYYTLDEIQEDMNCGHDKATKLLVELDNGKNGFGLIERVRQGQGRPTKIYVKRFTTRDIPSPSSELEAGQSSRPRRISGQECGKTALLNAEKPQSRPRENRSLECGKTAGSYIKSNQTENSQLNQSILPSVSPGESGWMDRYDCEKEIEANIEYDRLCRQFACEDVDEIVALIVDTLYTTRPTVRIGGDYISTDVVRERFLRLTYEHLEYVFDCLRRNTTEIRNIRGYLLTTLYNAPVTINHHYRAEVQHDLDR
>NZ_KE159707.1|WP_016321837.1|278683_279055_+|metal-dependent-transcriptional-regulator
MTIHESAEDYLEAILILRDRRGAVRSIDIVNELGYSKPSVSIAMKKLRENGYISMASDGFITLNDSGLEIASRVYHRHRTLTELFTLLGVSPENAAADACKVEHDLSEETFARIHDFVKSRKA
>NZ_KE159707.1|WP_016321838.1|279085_279916_-|delta-lactam-biosynthetic-de-N-acetylase
MKERPNRYWAALLVPLALCALGAALLYHPSGAFVPASSPAAVPASTDNWGLSFQTEGACPVGNATVEQLAQYDAYFLGDTSQKVIYLTFDCGYENGYTEQILDALKKHQAPAAFFVVGNMIETAPDIIRRMAKEGHIVGNHTFHHPDMSKISDQAAFQKELDDLAALYKETTGEDLPNYYRPPQGKYSEENLKQAQALGYKTVFWSLAYVDWYVDNQPTAEQAYAKLLPRIHDGAVVLLHSTSKTNAEILDDLLTKWEDMGYTFASLDQLPSCGSA
>NZ_KE159707.1|WP_016321839.1|280058_280631_-|hypothetical-protein
MYETYLRQLLSPLGIYDLGGGSVNGAELYALGQILDRTGRRLEIVERESVTATAEDEGLRRREAPFARRPAAVTPEERRDAIAALLQIDGDSLTPSAIDHAIQGCGIRARALEMDTGHLRVIFPGVGGVPAEFEQIEKIILDILPCHLEVEFYFRYLTWEECRRAGYTWAAVEEAEHTWESFQLAVPPEE
>NZ_KE159707.1|WP_016321840.1|280634_281693_-|hypothetical-protein
MKSVDEIYQELLVAFARRAGFTPEDACDLSVRLYAAAAQIQALDIQAEWVLDQSFPQTAQGVYLDRHAAMRGLSRLPASRAVGTLRFSVESPPALAVNIPAGTVCMTADERRFQTTAGATLAAGATYADAPAEALEAGGGGNAVAGAVRFLTACPVAVTACTNPAAFSGGSDAEDDETLRRRVLESYRRLPNGANAAWYEQTAMSHDGVAAARAVGRARGIGTVDVYIAGESGLPGAALLEEVRADLRERREIAVDVAVKAPAAVPVNVSAAIAVGENADFGEVKARAELAISTLFTGRMLGRPVLLAELGSRLYALEGVENCRLSAPAADLAADSAVLPVLGTLTVTKLEA
>NZ_KE159707.1|WP_016321841.1|281707_282055_-|hypothetical-protein
MELKLRSGDYVPDGVGGLLRVEGREALLQRALFRLTARRGVFPFLPELGSRLWQLGKVPPAQRQAAAAQYAAEALEGEALAVESAELGPGAEGAMALTVNCVWQGEPLPVTVEIV
>NZ_KE159707.1|WP_016321842.1|282066_282465_-|hypothetical-protein
MWLSSKMRPAPATADADLGVTTIAGDSVGVMTRGEVRTVPIYGPGGYVWMPESGAAVLVVKGGPGGEEQCVCGMKQSAPPKGMRPGEALVYGPGGNSVYLKQDGTLELRGKVCVEGSLLVNGIPYAPCECEM
>NZ_KE159707.1|WP_016321843.1|282469_283414_-|hypothetical-protein
MTGRIFTCDHRVYDLPELLSWEVVHTGTVPCDSYSVTFLYDKSMAEALRLAAGFAAIDRGTTMLRATVDEYAVELGAGGLTAAVAGRGYAARLLDNESRPLTYQEATLAEIVRCHVTPYGITAGEVADVRADSVYTVPAGVSQWRALEGFCRTYGGFSPRFSRDGKLLAAPERDSGRRLSIGEGDPVLSCTLREDHYGVLTEALVIDKTRNAYYSVKNEDMIRRGGQCRRVIYTPGQSTWDAMRYTGEYQIRRSKEDERTVTVRLPGSFLAFPGDRVDLRLDRMGLSGTFRVAEAASTFSAERGAAAALTLKGG
>NZ_KE159707.1|WP_016321844.1|283410_283980_-|LysM-peptidoglycan-binding-domain-containing-protein
MRFKDYTWPHNPEIYTVENRRRVAVHQVPFGSCVFQELGGTYRILRGEGEFSGADAYDQFRRLEAVFQEGGPGQLVHPVWRVQRAYFVSLRAEEKPLPDYVRYGFEFWEDCGGYDGGLTESDDGGALSRPGSQSGGIAGGSGAVHIVKKGDTLWGIARQYGAALTDLIAANPQIKNPNLIYPGNEVRLP
>NZ_KE159707.1|WP_016321845.1|284207_284792_-|hypothetical-protein
MDYIQEELRRQRAALARVLLGGGFPQSGADGEGAAAALRTAAAAAETVLAPVRGVVFRPAEGDAASNGDGGWAVPGIPGYRARTAVHGERAASGETAEFARRDGWAGPAGYGRQRGEAGRLAGTVLPGLAGGGQAEETAGPAAARRTAGGAVLEQRVTEFVPAAGGGERAVEAEALSRTFQRDARRYDGGFSLY

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Crispr_ID: NZ_KE159707_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159707_1

275948-276091

Orphan

Consensus_repeat	Method
TCATCAGCCTTACCGGGAGCGGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_KE159707_1

>merge|NZ_KE159707|1|275948-276091|CRISPRCasFinder
TCATCAGCCTTACCGGGAGCGGCGGCATCTGCCGCCTTGGTCTGCTCCGGTGGCTTCTTCTCGTCAGCCTTACCGGGAGCGGCAACACCTGCCGCCTTGATCTGCTCCGGCGGCTTCTTCTCGTCAGCCTTACCGGGAGCGGCG

>NZ_KE159707|1|1|275948-276091|CRISPRCasFinder
TCATCAGCCTTACCGGGAGCGGC	GGCATCTGCCGCCTTGGTCTGCTCCGGTGGCTTCTTC
TCGTCAGCCTTACCGGGAGCGGC	AACACCTGCCGCCTTGATCTGCTCCGGCGGCTTCTTC
TCGTCAGCCTTACCGGGAGCGGCG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159707.1\|WP_016321836.1\|276630_277596_-\|replication-initiator-protein-A	unknown	unknown	gnl\|CDD\|369151
NZ_KE159707.1\|WP_016321832.1\|273294_274233_-\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|368753
NZ_KE159707.1\|WP_016321833.1\|274290_274575_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321838.1\|279085_279916_-\|delta-lactam-biosynthetic-de-N-acetylase	unknown	unknown	gnl\|CDD\|131930
NZ_KE159707.1\|WP_016321837.1\|278683_279055_+\|metal-dependent-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224240
NZ_KE159707.1\|WP_016321824.1\|267659_267965_-\|MobC-family-plasmid-mobilization-relaxosome-protein	unknown	unknown	gnl\|CDD\|368576
NZ_KE159707.1\|WP_016321827.1\|269504_270320_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376271
NZ_KE159707.1\|WP_016321828.1\|270332_271193_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376271
NZ_KE159707.1\|WP_016321841.1\|281707_282055_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321839.1\|280058_280631_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378379
NZ_KE159707.1\|WP_016321842.1\|282066_282465_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321831.1\|272224_273121_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376259
NZ_KE159707.1\|WP_016321840.1\|280634_281693_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377414
NZ_KE159707.1\|WP_016321830.1\|271614_272214_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321845.1\|284207_284792_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321825.1\|267961_268360_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321826.1\|268423_269278_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016321844.1\|283410_283980_-\|LysM-peptidoglycan-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|131945
NZ_KE159707.1\|WP_016321829.1\|271205_271598_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376262
NZ_KE159707.1\|WP_016321843.1\|282469_283414_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_KE159707.1\|WP_016321836.1\|276630_277596_-\|replication-initiator-protein-A	gnl\|CDD\|369151	pfam06970, RepA_N, Replication initiator protein A (RepA) N-terminus. This of family of predicted proteins represents the N-terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids. Most proteins in this family are bacterial, but archaeal and eukaryotic members are also included.	2.71209e-32
NZ_KE159707.1\|WP_016321832.1\|273294_274233_-\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	0.00394482
NZ_KE159707.1\|WP_016321838.1\|279085_279916_-\|delta-lactam-biosynthetic-de-N-acetylase	gnl\|CDD\|131930	TIGR02884, spore_pdaA, delta-lactam-biosynthetic de-N-acetylase. Muramic delta-lactam is an unusual constituent of peptidoglycan, found only in bacterial spores in the peptidoglycan wall, or spore cortex. The proteins in this family are PdaA (yfjS), a member of a larger family of polysaccharide deacetylases, and are specificially involved in delta-lactam biosynthesis. PdaA acts immediately after CwlD, an N-acetylmuramoyl-L-alanine amidase and performs a de-N-acetylation. PdaA may also perform the following transpeptidation for lactam ring formation, as heterologous expression in E. coli of CwlD and PdaA together is sufficient for delta-lactam production. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination].	2.54176e-112
NZ_KE159707.1\|WP_016321840.1\|280634_281693_-\|hypothetical-protein	gnl\|CDD\|377414	pfam04865, Baseplate_J, Baseplate J-like protein. The P2 bacteriophage J protein lies at the edge of the baseplate. This family also includes a number of bacterial homologs, which are thought to have been horizontally transferred.	8.17267e-48
NZ_KE159707.1\|WP_016321824.1\|267659_267965_-\|MobC-family-plasmid-mobilization-relaxosome-protein	gnl\|CDD\|368576	pfam05713, MobC, Bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region. The absence of MobC has several different effects on oriT DNA. Site- and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency of mobilisation. The localized DNA strand separation required for this nicking is less affected, but becomes more sensitive to the level of active DNA gyrase in the cell. In addition, strand separation is not efficiently extended through the region containing the nick site. These effects suggest a model in which MobC acts as a molecular wedge for the relaxosome-induced melting of oriT DNA. The effect of MobC on strand separation may be partially complemented by the helical distortion induced by supercoiling. However, MobC extends the melted region through the nick site, thus providing the single-stranded substrate required for cleavage by MobA.	1.15027e-06
NZ_KE159707.1\|WP_016321827.1\|269504_270320_-\|hypothetical-protein	gnl\|CDD\|376271	pfam18852, LPD34, Large polyvalent protein associated domain 34. This is a predicted enzymatic alpha and beta fold domain with a large, prominent helix with conserved glutamate residue and several additional conserved residues including the motifs HTxN and SN. The domain is associated with polyvalent proteins of firmicute conjugative elements.	5.88791e-89
NZ_KE159707.1\|WP_016321828.1\|270332_271193_-\|hypothetical-protein	gnl\|CDD\|376271	pfam18852, LPD34, Large polyvalent protein associated domain 34. This is a predicted enzymatic alpha and beta fold domain with a large, prominent helix with conserved glutamate residue and several additional conserved residues including the motifs HTxN and SN. The domain is associated with polyvalent proteins of firmicute conjugative elements.	6.20936e-93
NZ_KE159707.1\|WP_016321839.1\|280058_280631_-\|hypothetical-protein	gnl\|CDD\|378379	pfam10076, DUF2313, Uncharacterized protein conserved in bacteria (DUF2313). Members of this family of proteins comprise various hypothetical and putative bacteriophage tail proteins.	0.000857249
NZ_KE159707.1\|WP_016321831.1\|272224_273121_-\|hypothetical-protein	gnl\|CDD\|376259	pfam18840, LPD25, Large polyvalent protein associated domain 25. This is an alpha and beta fold domain found in polyvalent proteins of conjugative elements.	3.7161e-20
NZ_KE159707.1\|WP_016321837.1\|278683_279055_+\|metal-dependent-transcriptional-regulator	gnl\|CDD\|224240	COG1321, TroR, Mn-dependent transcriptional regulator [Transcription].	3.60187e-26
NZ_KE159707.1\|WP_016321844.1\|283410_283980_-\|LysM-peptidoglycan-binding-domain-containing-protein	gnl\|CDD\|131945	TIGR02899, hypothetical_conserved_protein, spore coat assembly protein SafA. SafA (YrbB) (SafA) of Bacillus subtilis is a protein found at the interface of the spore cortex and spore coat, and is dependent on SpoVID for its localization. This model is based on the N-terminal LysM (lysin motif) domain (see pfamAM model pfam01476) of SafA and, from several other spore-forming species, the protein with the most similar N-terminal region. However, this set of proteins differs greatly in C-terminal of the LysM domaim; blocks of 12-residue and 13-residue repeats are found in the Bacillus cereus group, tandem LysM domains in Thermoanaerobacter tengcongensis MB4, etc. in which one of which is found in most examples of endospore-forming bacteria. [Cellular processes, Sporulation and germination].	1.12191e-16
NZ_KE159707.1\|WP_016321829.1\|271205_271598_-\|hypothetical-protein	gnl\|CDD\|376262	pfam18843, LPD28, Large polyvalent protein associated domain 28. This is a beta strand rich domain that lacks strongly conserved polar residues. It is fast diverging and is found in polyvalent proteins of conjugative elements.	9.04934e-35

>NZ_KE159707.1|WP_016321833.1|274290_274575_-|hypothetical-protein
MKKQTIVGGYTIIERKQAGEVMVVVGHNPKASSPYVTWKAYDFTNFTSFNHGHYFLTRQEAMVDYFQRLAEVWEHYTPARHTPPKHRENDPPAK
>NZ_KE159707.1|WP_016321832.1|273294_274233_-|ImmA/IrrE-family-metallo-endopeptidase
MGKTLSPDQLKVWTDRLEAGVSELHDSQRYADYLSAMSKFHRYSYGNIILILQQCPHAQQVAGYHKWKNTFGRQVKRYETGITILAPCKYKCQVKAETAGGDEEPVQDTAVVEKCRFRTETVFDVSQTVGRELPSLGIAQLTGNVEGYDSLIGALKELSPVPVDTGVLRAGAYGCYSHVEERIIIQKDLTQVQTVKTLIHEIAHAKLHTLPVLNGVIMGSHQKGKSTREIEAESVAYVVCQYLGIDTSEYSLGYVAGWGRDREMRAFKSSLTCIRNTAAELIGGIESRCLKPEIERPAEEETRRQTDRTAVR
>NZ_KE159707.1|WP_016321831.1|272224_273121_-|hypothetical-protein
MENRLREIAGNLKQDVKDLLEESVNIVTGLIKQGVCTANGMTKRWNAFTNGLSQAAKALFEPFSYAPIVTENQQPLVTVRESTCEELPVGTRMTLAEAEERIEELNLSMIDSGGLIQDVKVTIDYRMDGEQDRYWLPLQIGSGQGSMLEQMEYIVRSCLHSPDSVTQDFYTASPGLGKLLHEHFGPQLHEDLEKLAERVLGYFQQHCTITRLEQQFALQAQVLPERDQQRFQESVKTAIAKFRRATNTGQAMEPVREQALPVHGDAQPRQSVKVKLHRIKDGRQKQPMLHKARNNPQR
>NZ_KE159707.1|WP_016321830.1|271614_272214_-|hypothetical-protein
MEKQIELIPFLERVVDQNTTHYKDDLQYDIIRFGEAVYKLEAEERAFYWMARPCGTQTVRERDAFLVGSDGHTIWTHYTYEAPKIQAYRIFVTGGTGGEPVGTVRRLDYPKQVRRVMANAIPAVRMELTFLSGEVREIALEDYPKEREWLFREYGMAKRVRYCPRDEDDLRFILTIEQRKQKRGRPRTAIKLNGSPVRE
>NZ_KE159707.1|WP_016321829.1|271205_271598_-|hypothetical-protein
MYSIDTVKERMETVEIFEIPGLFSVKRIDRVAIPKGMYAYDLQASKEDWGQPCRIGYQITERYFGTVLTASPVALPESGYCEAGPHDFIQGEKTERLTVAEFEAKYLSPNPEVQCRHRRWRRCFSSVSVR
>NZ_KE159707.1|WP_016321828.1|270332_271193_-|hypothetical-protein
MASQQPFYMVSSYTGNLREGQHIEVRRQILYQGENADFKPFAQFPVKELEKRLKKSLKAEKKIFNEMQRAIKAWDEHGAETLLLQKAIAYIKTPVVKHTGNEWKKRKDGAWEISNLVYHMMFKIEKHGDEWHLTWGLQYTAPALPKDYIPAPYNGWPKRRLEYESNKKYRTLDGAQKYIQAKFDQYATLFSELSPPVPEAVKRLFCVSGQLLPGYTLAEPERTEPDRKLVDELLNYLGEGDLDKSSPAQEERAPPVPEEQATPSPKPAHRTAKPQNRKKAKTNPVR
>NZ_KE159707.1|WP_016321827.1|269504_270320_-|hypothetical-protein
MSLNPGKELKLIYYAGLSLEKADLSDLAALTREELKTREQESVTKEEEVYGEIENLISEWARQAGETIRLRKTLEYLGVPAVRHTSNQWVKGDYDWYEMSNMVYKMTCRVSESTNWRSPQRPRPIYWELTWSLVFNTPQNPDYSGHGRQIAGQRQKRFDDKAALEKYLRGRIKAYAHLFTELSPPIPKEHCRRFCVNGLLLPGYAVDSPEVIAPDESAVEELLGFLNDGDLPGDSQETQIAQQPETSPEEIWSRHRKQRQETVQNKQAPTR
>NZ_KE159707.1|WP_016321826.1|268423_269278_-|hypothetical-protein
MLSWEPLNILSFGAGTPSTTLALMSCENALRGRPVWPHVPIYHAVIFCDLHGEPNWVYRQAAFVASACTAAGIPYYTLDANLYRDWTENFGRARVSSIPFWTLSADGKKGRMPRQCTYDYKIKRIEQFVRYELLCYRPKERALKIDIHAHTLHMGIMWEERHRAKESKQTLFVNRYPLIEMKWTRSACYTYNRDVWGLDTKASCCLFCPFHTNYFYRYIRQNEPACYNCALQVDRIAEIYQARPPVKSELFLSKSRKRLRDLNDADCNDVKYFWYKSFLVWDGF
>NZ_KE159707.1|WP_016321825.1|267961_268360_-|hypothetical-protein
MREPSFSPWGEIQSCDTLYPGIYLVTTPGHGGIIVEPTAALYLSSNARKCGFRDGGYLCFEEDCCEQVVLRELLDRGMWKLPERIKDKEGFEKEINRTIEKYHPNYWRARAAGKTVPRPVTCSRQRKEAPTR
>NZ_KE159707.1|WP_016321824.1|267659_267965_-|MobC-family-plasmid-mobilization-relaxosome-protein
MRPYKTITLRLNAAEYAHLKALSDTTGLKMEPTLRKLVMGVQLRPRPPDTYAALLRELSAIGNNVNQIAHNTNAAKTVTQAEIDEAVQLVRQAWRLVKEAL
>NZ_KE159707.1|WP_016321836.1|276630_277596_-|replication-initiator-protein-A
MAAKALYDYYYGDESSQFSFYRIPRQLITGDCFKRLSTDAKLLYGLLLDRMSLSAKNGWYDKQGRVYIYYTLDEIQEDMNCGHDKATKLLVELDNGKNGFGLIERVRQGQGRPTKIYVKRFTTRDIPSPSSELEAGQSSRPRRISGQECGKTALLNAEKPQSRPRENRSLECGKTAGSYIKSNQTENSQLNQSILPSVSPGESGWMDRYDCEKEIEANIEYDRLCRQFACEDVDEIVALIVDTLYTTRPTVRIGGDYISTDVVRERFLRLTYEHLEYVFDCLRRNTTEIRNIRGYLLTTLYNAPVTINHHYRAEVQHDLDR
>NZ_KE159707.1|WP_016321837.1|278683_279055_+|metal-dependent-transcriptional-regulator
MTIHESAEDYLEAILILRDRRGAVRSIDIVNELGYSKPSVSIAMKKLRENGYISMASDGFITLNDSGLEIASRVYHRHRTLTELFTLLGVSPENAAADACKVEHDLSEETFARIHDFVKSRKA
>NZ_KE159707.1|WP_016321838.1|279085_279916_-|delta-lactam-biosynthetic-de-N-acetylase
MKERPNRYWAALLVPLALCALGAALLYHPSGAFVPASSPAAVPASTDNWGLSFQTEGACPVGNATVEQLAQYDAYFLGDTSQKVIYLTFDCGYENGYTEQILDALKKHQAPAAFFVVGNMIETAPDIIRRMAKEGHIVGNHTFHHPDMSKISDQAAFQKELDDLAALYKETTGEDLPNYYRPPQGKYSEENLKQAQALGYKTVFWSLAYVDWYVDNQPTAEQAYAKLLPRIHDGAVVLLHSTSKTNAEILDDLLTKWEDMGYTFASLDQLPSCGSA
>NZ_KE159707.1|WP_016321839.1|280058_280631_-|hypothetical-protein
MYETYLRQLLSPLGIYDLGGGSVNGAELYALGQILDRTGRRLEIVERESVTATAEDEGLRRREAPFARRPAAVTPEERRDAIAALLQIDGDSLTPSAIDHAIQGCGIRARALEMDTGHLRVIFPGVGGVPAEFEQIEKIILDILPCHLEVEFYFRYLTWEECRRAGYTWAAVEEAEHTWESFQLAVPPEE
>NZ_KE159707.1|WP_016321840.1|280634_281693_-|hypothetical-protein
MKSVDEIYQELLVAFARRAGFTPEDACDLSVRLYAAAAQIQALDIQAEWVLDQSFPQTAQGVYLDRHAAMRGLSRLPASRAVGTLRFSVESPPALAVNIPAGTVCMTADERRFQTTAGATLAAGATYADAPAEALEAGGGGNAVAGAVRFLTACPVAVTACTNPAAFSGGSDAEDDETLRRRVLESYRRLPNGANAAWYEQTAMSHDGVAAARAVGRARGIGTVDVYIAGESGLPGAALLEEVRADLRERREIAVDVAVKAPAAVPVNVSAAIAVGENADFGEVKARAELAISTLFTGRMLGRPVLLAELGSRLYALEGVENCRLSAPAADLAADSAVLPVLGTLTVTKLEA
>NZ_KE159707.1|WP_016321841.1|281707_282055_-|hypothetical-protein
MELKLRSGDYVPDGVGGLLRVEGREALLQRALFRLTARRGVFPFLPELGSRLWQLGKVPPAQRQAAAAQYAAEALEGEALAVESAELGPGAEGAMALTVNCVWQGEPLPVTVEIV
>NZ_KE159707.1|WP_016321842.1|282066_282465_-|hypothetical-protein
MWLSSKMRPAPATADADLGVTTIAGDSVGVMTRGEVRTVPIYGPGGYVWMPESGAAVLVVKGGPGGEEQCVCGMKQSAPPKGMRPGEALVYGPGGNSVYLKQDGTLELRGKVCVEGSLLVNGIPYAPCECEM
>NZ_KE159707.1|WP_016321843.1|282469_283414_-|hypothetical-protein
MTGRIFTCDHRVYDLPELLSWEVVHTGTVPCDSYSVTFLYDKSMAEALRLAAGFAAIDRGTTMLRATVDEYAVELGAGGLTAAVAGRGYAARLLDNESRPLTYQEATLAEIVRCHVTPYGITAGEVADVRADSVYTVPAGVSQWRALEGFCRTYGGFSPRFSRDGKLLAAPERDSGRRLSIGEGDPVLSCTLREDHYGVLTEALVIDKTRNAYYSVKNEDMIRRGGQCRRVIYTPGQSTWDAMRYTGEYQIRRSKEDERTVTVRLPGSFLAFPGDRVDLRLDRMGLSGTFRVAEAASTFSAERGAAAALTLKGG
>NZ_KE159707.1|WP_016321844.1|283410_283980_-|LysM-peptidoglycan-binding-domain-containing-protein
MRFKDYTWPHNPEIYTVENRRRVAVHQVPFGSCVFQELGGTYRILRGEGEFSGADAYDQFRRLEAVFQEGGPGQLVHPVWRVQRAYFVSLRAEEKPLPDYVRYGFEFWEDCGGYDGGLTESDDGGALSRPGSQSGGIAGGSGAVHIVKKGDTLWGIARQYGAALTDLIAANPQIKNPNLIYPGNEVRLP
>NZ_KE159707.1|WP_016321845.1|284207_284792_-|hypothetical-protein
MDYIQEELRRQRAALARVLLGGGFPQSGADGEGAAAALRTAAAAAETVLAPVRGVVFRPAEGDAASNGDGGWAVPGIPGYRARTAVHGERAASGETAEFARRDGWAGPAGYGRQRGEAGRLAGTVLPGLAGGGQAEETAGPAAARRTAGGAVLEQRVTEFVPAAGGGERAVEAEALSRTFQRDARRYDGGFSLY

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Crispr_ID: NZ_KE159707_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159707_3

768315-768409

Orphan

Consensus_repeat	Method
GTGGTCTCCCCGTCCTTCTTCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_KE159707_3

>merge|NZ_KE159707|3|768315-768409|CRISPRCasFinder
GTGGTCTCCCCGTCCTTCTTCTCAGGGTCGGCGGGGGTGGTCTCCCCGTCCTTCTTCTCAGGGTCGGCGGGGGTGGTCTCTCCGTCCTTCTTCTC

>NZ_KE159707|3|3|768315-768409|CRISPRCasFinder
GTGGTCTCCCCGTCCTTCTTCTC	AGGGTCGGCGGGGGTGGTCTCCCCGTCCTTCTTCTCAGGGTCGGCGGGG
GTGGTCTCTCCGTCCTTCTTCTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159707.1\|WP_016322322.1\|771926_774593_-\|DNA-polymerase-I	unknown	unknown	gnl\|CDD\|235591
NZ_KE159707.1\|WP_016322311.1\|761288_762479_+\|knotted-carbamoyltransferase-YgeW	unknown	unknown	gnl\|CDD\|274517
NZ_KE159707.1\|WP_016322310.1\|759458_760871_+\|YgeY-family-selenium-metabolism-linked-hydrolase	unknown	unknown	gnl\|CDD\|349900
NZ_KE159707.1\|WP_081646314.1\|756131_757046_-\|DMT-family-transporter	unknown	unknown	gnl\|CDD\|223769
NZ_KE159707.1\|WP_016322313.1\|763877_764957_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366010
NZ_KE159707.1\|WP_016322326.1\|778168_778678_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
NZ_KE159707.1\|WP_016322323.1\|774900_776001_-\|PhnD/SsuA/transferrin-family-substrate-binding-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016322308.1\|757130_758606_-\|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl\|CDD\|223110
NZ_KE159707.1\|WP_016322327.1\|779141_779828_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016322315.1\|766480_767425_-\|carbamate-kinase	unknown	unknown	gnl\|CDD\|237071
NZ_KE159707.1\|WP_051147076.1\|770288_770771_-\|ribosomal-protein-S18-alanine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|273701
NZ_KE159707.1\|WP_016322314.1\|765400_766366_+\|calcium/sodium-antiporter	unknown	unknown	gnl\|CDD\|273039
NZ_KE159707.1\|WP_016322324.1\|776316_776805_+\|RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NZ_KE159707.1\|WP_016322325.1\|776788_777847_+\|DUF4179-domain-containing-protein	unknown	unknown	gnl\|CDD\|379369
NZ_KE159707.1\|WP_016322318.1\|769275_770292_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	unknown	unknown	gnl\|CDD\|236585
NZ_KE159707.1\|WP_016322312.1\|762715_763657_+\|carbamate-kinase	unknown	unknown	gnl\|CDD\|237071
NZ_KE159707.1\|WP_016322320.1\|770779_771265_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_016322321.1\|771261_771930_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|180650
NZ_KE159707.1\|WP_155978969.1\|760879_761260_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159707.1\|WP_155978988.1\|758602_759229_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|377981

Protein	Function_ID	Function_description	E-value
NZ_KE159707.1\|WP_016322322.1\|771926_774593_-\|DNA-polymerase-I	gnl\|CDD\|235591	PRK05755, PRK05755, DNA polymerase I; Provisional.	0
NZ_KE159707.1\|WP_016322311.1\|761288_762479_+\|knotted-carbamoyltransferase-YgeW	gnl\|CDD\|274517	TIGR03316, aspartate/ornithine_carbamoyltransferase, knotted carbamoyltransferase YgeW. Members of this protein family include the ygeW gene product of Escherichia coli. The function is unknown. Members show homology to ornithine carbamoyltransferase (TIGR00658) and aspartate carbamoyltransferase (carbamoyltransferase), and therefore may belong to the carbamoyltransferases in function. Members often are found in a large, conserved genomic region associated with selenium-dependent molybdenum hydroxylases.	0
NZ_KE159707.1\|WP_016322310.1\|759458_760871_+\|YgeY-family-selenium-metabolism-linked-hydrolase	gnl\|CDD\|349900	cd05649, M20_ArgE_DapE-like, M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases. Peptidase M20 family, uncharacterized protein subfamily with similarity to acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE) subfamily. This group includes the hypothetical protein ygeY from Escherichia coli, a putative deacetylase, but many in this subfamily are classified as unassigned peptidases. ArgE/DapE enzymes catalyze analogous reactions and share a common activator, the metal ion (usually Co2+ or Zn2+). ArgE catalyzes a broad range of substrates, including N-acetylornithine, alpha-N-acetylmethionine and alpha-N-formylmethionine, while DapE catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelate (L,L-SDAP) to L,L-diaminopimelate and succinate. Proteins in this subfamily are mostly bacterial and archaeal, and have been inferred by homology as being related to both ArgE and DapE.	0
NZ_KE159707.1\|WP_081646314.1\|756131_757046_-\|DMT-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.13937e-16
NZ_KE159707.1\|WP_016322313.1\|763877_764957_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	3.49451e-51
NZ_KE159707.1\|WP_016322326.1\|778168_778678_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	3.34221e-12
NZ_KE159707.1\|WP_016322308.1\|757130_758606_-\|pyridoxal-phosphate-dependent-enzyme	gnl\|CDD\|223110	COG0031, CysK, Cysteine synthase [Amino acid transport and metabolism].	4.38827e-25
NZ_KE159707.1\|WP_016322315.1\|766480_767425_-\|carbamate-kinase	gnl\|CDD\|237071	PRK12353, PRK12353, putative amino acid kinase; Reviewed.	0
NZ_KE159707.1\|WP_016322314.1\|765400_766366_+\|calcium/sodium-antiporter	gnl\|CDD\|273039	TIGR00367, Uncharacterized_membrane_protein_MJ0091, K+-dependent Na+/Ca+ exchanger related-protein. This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General].	1.61287e-52
NZ_KE159707.1\|WP_016322324.1\|776316_776805_+\|RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	3.42554e-34
NZ_KE159707.1\|WP_016322325.1\|776788_777847_+\|DUF4179-domain-containing-protein	gnl\|CDD\|379369	pfam13786, DUF4179, Domain of unknown function (DUF4179).	2.93594e-13
NZ_KE159707.1\|WP_016322318.1\|769275_770292_-\|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD	gnl\|CDD\|236585	PRK09604, PRK09604, tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD.	1.08849e-161
NZ_KE159707.1\|WP_016322312.1\|762715_763657_+\|carbamate-kinase	gnl\|CDD\|237071	PRK12353, PRK12353, putative amino acid kinase; Reviewed.	0
NZ_KE159707.1\|WP_016322321.1\|771261_771930_-\|hypothetical-protein	gnl\|CDD\|180650	PRK06665, flgK, flagellar hook-associated protein FlgK; Validated.	0.00491327
NZ_KE159707.1\|WP_051147076.1\|770288_770771_-\|ribosomal-protein-S18-alanine-N-acetyltransferase	gnl\|CDD\|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR\|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	3.57325e-47
NZ_KE159707.1\|WP_155978988.1\|758602_759229_-\|transcriptional-regulator	gnl\|CDD\|377981	pfam08348, PAS_6, YheO-like PAS domain. This family contains various hypothetical bacterial proteins that are similar to the E. coli protein YheO. Their function is unknown, but are likely to be involved in signalling based on the presence of this PAS domain.	4.15897e-53

>NZ_KE159707.1|WP_016322315.1|766480_767425_-|carbamate-kinase
MPERIVIALGGNALQSKDSGATAEAQLEVVKKTSVHIAQISQRGYEMAVVHGNGPQVGRIVLASEAAKDVAPPMPFDVCGAMSQGYIGYHIQQALKYALNSRNRNYPVVTLATQVVVDRNDPAFQNPTKPIGAFYTQEEARHLEAERGYTMREDAGRGWRRVVPSPQPRRIVEIEAIRLLWDHAIVVACGGGGIPVVENPDGTLEGVAAVIDKDFAAELLAEAVGADVLLILTEVEKAAIRFGKPDQQDLDHISLAEAAQYAAEGQFGVGSMLPKVEAAMKFVRANPGKRAIITSLDKALDALDGKTGTTVTFA
>NZ_KE159707.1|WP_016322314.1|765400_766366_+|calcium/sodium-antiporter
MSIWVTVLLFLLGLALIVKGGDWFLDGAVWIAEATGVPRFIIGATIVSLATTLPELTVSVTGVLQGEVDLAVGNAVGSVTANLGLILGISIVCIPSAVNRKQFDLKAILMVSGALLLFLLCRGGVLPVLPSLLLFVVFAIYLGNNVMDARSGMAESRGTNPKRRTTSHRQMFMKLGLFAVGIVAIVIGSRLLIDYGSELALLLGVPSSIIGVTMVAIGTSLPELVTTLTAIAKKEASMSVGNIVGANVIDLTMILPVCSAVSTAGGDKLVIGSQTTALDLPVCLGLCCLAVLPPLVKGKFFRWQGALMLAVYTAYVVMLVS
>NZ_KE159707.1|WP_016322313.1|763877_764957_+|GNAT-family-N-acetyltransferase
MTTIYLIRHAEAEGNLYRIAQGQDDSALTDRGWRQVKALERRFDGVRIDAVYTSDLYRACATASALYLPRGLTPCRRRDLREIHVGVWERKTWGEIARRWQPQMEDFSCRMDRWHMEGAETPAEVLERALNALRQIAAENEGKTAAVFSHGYVIRLVLANLQGISLRDTGDRTPTGDNTAVSVLEWDGAALRVVRQNDNSHLMTPEYLAGEKVRKRASALEPGLYFAPPRLPEQEAMLAELTAASWEGEPPVPDSGCPALTGYLGEEPVGLVRFGPTLGEIALICVRRDCRRRGFGVQLIGQAVYHWRPLGADRLRIVLPEGCAAEGFFGDYGFAPAEAAGPDGRLWVKDIGFDPLFKS
>NZ_KE159707.1|WP_016322312.1|762715_763657_+|carbamate-kinase
MGKRIVVALGGNALGNNLPEQMAAVKQTARAIADLIEDGNEVIVAHGNGPQVGMIQKAMAELTRSNPEKYIPCPLSVCVAMSQGYIGYDLQNALREELLDRNIQKGVATVLTQVEVDPQDPAFRNPTKPIGAFMTEEEAKRMVAERGYDVMEDSGRGWRRVVASPKPVSVIELDTIQALVESDHIVVACGGGGIPVFKTEGHHLKGAAAVIDKDFASEVLAEELNADVLIILTAVEKVAVNFGKPDQKWLDHLTAEEARQYAAEGQFAPGSMLPKVEAAVKFAESKPGRTALITLLEKAKAGIAGETGTSISL
>NZ_KE159707.1|WP_016322311.1|761288_762479_+|knotted-carbamoyltransferase-YgeW
MSKTIELAQHLEKLHINNMYKSDFYWTWDKTDEELDAIFTVADALRDLRERNKSTRIFDSGLGISIFRDNSTRTRFSFASACNLLGLNVQDLDEKKSQIAHGETVRETANMVSFMADVIGIRDDMFIGEGHKYQKTFMDAVKEGYRDGILEQQPTLVNLQCDVDHPTQAMADMLHIIHQFGGVENLKGKKLAMTWAYSPSYGKPLSVPQGVIGLMTRFGMDVVLAHPEGYDVMPEVEEIAKKNAAATGGSYKKAATMEEAFDGADIVYPKSWAPFAAMEERTKLYQAGDQKGIDELEKKLLAQNAQHKNWTCSEEMMKRTKDGKALYLHCLPADITGLSCPEGEVDNSVFDRYLVPLYKEASYKPYVIAAMIMMSKVKDPVAALMAMDSGKARKVF
>NZ_KE159707.1|WP_155978969.1|760879_761260_+|hypothetical-protein
MQLIVSGLGLAALLALALAFPLVADEKSLGTAVRSGAFSLAAVLVILLISRLITEFADALGGMVHDIVRLPAVLLYFLAAFHPGSHRQILLTPPETVMPQSLEKATSGFKSICRGQIPALSIIHCL
>NZ_KE159707.1|WP_016322310.1|759458_760871_+|YgeY-family-selenium-metabolism-linked-hydrolase
MDFEAIKTAAEGYKAEMSRFLRDMISHPSESCEEKDVVMCIKAEMEKLGFDKVEIDGLGNVIGWMGQGEKIIAIDSHIDTVGIGNISNWEADPYAGYETDDIIYGRGGSDQEGGMASAVYGAKIMRDMGLIPEGYKIMVVGSVQEEDCDGMCWQYIVNKYFNGPEDARSKIEFVISTEPTDGGIYRGHRGRMEIRVDVKGVSCHGSAPERGDNAIYKMADILQDVRALNENGDGPSNTVKGLVKMLNEEFNPQHYEDARFLGRGTCTTSQIFYTSPSRCAVADSCAISIDRRMTAGETWDSCLQEIRDLPSVQKYGDDVKVSMYMYDRPAWTGTVYETECFFPTWINKESAAHVQALIDAHHALWGDKRIGHADADPKKDAMHLRDGRPLTDKWTFSTNCVSIQGRYGIPCVGFGPGAESQAHAPNEITWKQDLVTCAALYAAAIPLYKPENKSDDVTEFRQSLTDNNIQ
>NZ_KE159707.1|WP_155978988.1|758602_759229_-|transcriptional-regulator
MLKQVAAGIAAQFGSSCEVVIHDLSRNPDHSIVAIINGHVSGRKVGDGASNVVMEQLQTNDPEPKDHLSYLMKTPDGKILKSSTVYIRNGKGKVSAILAINYDISALLMVESALHGLVSTEGPQPTEPEKIVNINDLLEELIQQSVALVGRPVALMNKDDKVRAIQFLNQNGAFLVTKSGDKVAKYFGISKYTLYSYIDTKLEEDKPL
>NZ_KE159707.1|WP_016322308.1|757130_758606_-|pyridoxal-phosphate-dependent-enzyme
MIDLSINKQGLAHNIKKAKENGIIIPTVAQMQRPETIPEKVQDKLKTLGLWDVDPMNLFRITWKNEARESGGLFQAVPNYVELPSSLTGVPCRIIAMVGKWFPTGCHKVGASFGCLAPRLVTGQFDVDVHKAVWPSTGNYCRGGAFNSRLLGAQGVAILPAEMSKERFDWLHEIGAEVIATPGCESNVKEIFDKTNELKLDPQYMIFNQFEEMGNPLWHYNVTGNALADVFEAVKRPGDRFAGAAFTSGSAGTMSAGDRLKELYPRLKLAVGEALQCPTILNNGFGGHRIEGIGDKHIPWIHNVKNSDMAIAIDDEDSQRLLRLFNTPEGQKYLKETLGLDGELIEKLTWLGISGIANVLCCIKMAKYYELTEHDVVGTVLTDSAVMYGSRIAELNDQHGAYTVQAAELDHNLHMLGLKTDSMMELTYAERKRVHHLKYYTWVEQQGKDMHDLNALWYDTEGTWDAVHAQARDLDELINAFNEETGVLKNL
>NZ_KE159707.1|WP_081646314.1|756131_757046_-|DMT-family-transporter
MKMTKGSAAWLLLAASAMWGSSFVASKYCISSGMLQFEIVFCRFSLGSLLTALVFRKQLRRPARSAVGTGFLLGLLTSLTFTLEMFGLAMTEASKASFLTATNIIMMPFLCALFFRTRPARRSLLAAALAMTGVGFLSLREGLGGAAPGDLLLLADAATYGLNSLLLVKLAGEDSRLQISFFQFLTTAACMGVLTLIQGTGGAYTRPAVLSVLYLAAVPTVLCYLIKNFTLKYLDPVRCTLILSTESIFCAVLSAALLGERMTPRMLAGAALICGGVAAEILRPAETPPEKAAEDAQILTEETK
>NZ_KE159707.1|WP_016322318.1|769275_770292_-|tRNA-(adenosine(37)-N6)-threonylcarbamoyltransferase-complex-transferase-subunit-TsaD
MKILAFESTCDETAAAVVEDGRRVLSDIVASQADMHALYGGVVPEIASRKHVEVIAALAEQALAQADCTRAGIDAVAASYAPGLIGAVLVGLSFAKSVAFGLGVPLIPVHHVRGHIAANYIAFPDLEPPFLTLAISGGNTLIVDVRDYTDMEILGSTRDDAAGECFDKAARVLGLSYPGGKPIDQLAQQSQGGVYALPHAQVDGAPLDMSFSGLKTAVVNLAHHARQVDGELDRAALARDFTQAVSDTLVPRTMEAARRTGRRTIVAAGGVAANSVIRSDLERACEEAGCRLYLPPLSLCGDNGAMIGAQGYYEYLAGNTAGMELNAYATRDISQAAP
>NZ_KE159707.1|WP_051147076.1|770288_770771_-|ribosomal-protein-S18-alanine-N-acetyltransferase
MRVRIVPMTADHLDAVAALERICFSDPWSRGLLAAELDNDLSAFLVALDSEDQVAGYAGLQVVLDEGTVTNIAVRPDCRRRGVASQLLQVFLNFAQGNHLAFLTLEVRASNYDAIALYGSRGFRSAGRRKNYYEHPREDAIIMTRNFSAPPAEAGEEACP
>NZ_KE159707.1|WP_016322320.1|770779_771265_-|hypothetical-protein
MTGTFGFSYVGAVFLLCLLVPNVLWTRYRPRDYAPSGESRPLLAMERTGQVWVTCAALVFQDFNLRPWTPWSWWLIGAAALMVLYELWWLRYFRSEHTMADFTSGLPGVPVAGAALPVAAFFLLGIYGRAVWMLPGVTVLGIGHIGIHLRHRREIRKETNI
>NZ_KE159707.1|WP_016322321.1|771261_771930_-|hypothetical-protein
MTREGQKKIREREKLLKKAMGKACRETGKRRGWKTVRGHQYRVRDNLLDVLIVMPSSFDSQILKANFYCKPPALDEMYWKVFRMAEEAAEQPFSFHVWGAFTARGLWLPAWQERLSGPEDLESAVEAIFDRAEALAAENVFPDLAAYRARLEAEERPKVLEIILRLLCEENYLRAMALIEENLARGESGGFSREGGRRSILEDARDYCAARLAERISGGTAP
>NZ_KE159707.1|WP_016322322.1|771926_774593_-|DNA-polymerase-I
MKLMAIDGNSIINRAYYGIRPLTTRDGLYTHAVFGFLTTLLRLMGEERPDAVCVTFDVHAPTFRHTADAAYKATRKPMPEELRMQMPVLKEVLDALNIPRWELTGWEADDLLGTISRKCEADGWECVVVTGDKDSLQLITDRTKVKLVSTRMGQTTTKDMTPETFREQYGFDPVHMIDLKALMGDASDNIPGVKGVGEKTAMGLIRMYGSIDRLYAQLPDILSAPETPARPGLVKKLTEGEASARHSQWLATIVTDAPLEFAPEDNLVKAPGPAAYPLFLKLEFAKLIEKFGLTPETAPAAERADLTAAVEQVADPARAAELMELWRGAECVSVTALPDLQALAVECRTGPDSALLADLRFSRYQGEWNALLADLFSADVPKAAHNVKDLMRVLLENGLPAEGFVFDTALAAYLLDATAGSYDLPRLFVSYYNEELPKPLFLEPDAFSPLGETAEVAASLYSHTSAVTALQKTLGEKLRERDMERLFAEIELPLCRVLAEMELAGCRVDRKALADFGEMLAARTAELEKTVYDLAGEKFNINSPKQLGEILFGKLGLPHGKKTKTGWSTNADVLENLRYEAPIVGAVLEYRQYAKLKSTYAEGLLKALDADGRVRTSFQMTVTATGRLSSTEPNLQNIPTRTDLGSEIRKMFIPAEGCVLVDADYSQIELRLLAHVSGDEAMRAAFLAGGDFHAETAAKVFHVDRADVTQEMRRGAKAVNFGIVYGISPFSLSQDLGVTTAEAKAYMDGYFAAFPGVRRYMDDVVSQAREAGYVETLFHRRRELPELKSSKFALRSFGERVALNMPIQGAAADVMKLAMIAVWKRLKAEGLEARLVLQVHDELIVECPAGEAERAATLLEEEMENVVRLSVPLTAEAHWGKNWLEAKG
>NZ_KE159707.1|WP_016322323.1|774900_776001_-|PhnD/SsuA/transferrin-family-substrate-binding-protein
MKKLLPLLLALALLLSGCARREDAPPDPVQDPSPGTEEPSGPGGYPLELDILRIEICRGGLGSERLMEAARTLPELLRSTLAENQSIIADTVQLTIGSSPAATVQALNAGAVDIAILPAEGFAGQETEAAVLLASGPGANESPLWADSSGAFQASICAAPTDYGLNLAARAGKEGDLPTWEEMNRARWGLLEQDSLPGRRAVDLWLADSFEGNTTANLSHVTVYGDFDHLIQAAEAGEIDVFPRDDSDPAARSGDTAEFLNEKVFSLGQTERFYDMVLAVSPEREDLSAPALNLKDPLMYTLTQLCFYDGTQTNADGTPLFSGVSFDRETRLLCQDVFGPYRYGWAEDKDLDAARRLLTLEGHTAD
>NZ_KE159707.1|WP_016322324.1|776316_776805_+|RNA-polymerase-sigma-factor
MNYSQQAERLAETYADAILRLSYTYLKNTQDAQDVCQTVFVKLLTEPRSFESPAHERAYILRMASNACKDILKSPWRQRTRPLEDGLQVPAPEAEDGSVLSAVNTLPPHYRAVIYLCYYEGYTAAEIGEILGVPTATVHTRLARGRTRLKEILGGMDYEQSV
>NZ_KE159707.1|WP_016322325.1|776788_777847_+|DUF4179-domain-containing-protein
MSNLSEYKQSMETLRFTPEQRARLAAEAAKAASRQAARRTRRPFGKMAVIAAAAAVMLAVGAGAAGVLPSPIDVFTPLFGGSVAQTEVIDKIGHPIGASATDNGITLSADAIMGDEYNAVIVYTLAREDGERFLPEGKGLDETYLMMGGFGSSWVKGGTHGTSWFVDQDPEDNMIQMVETVSSDAPMSHGTAAVDFQDLRYWDHETERDELLYEGRWKFRFEVNYEDCSVRMGGGETFSQDGLVFTIDGISVSPVAVKVNYTADTEVVWSNSGSGRQAPEDARQSQRYLENVEILLTKADGTVIDLSTSGGSLRPGNGVTVCSKGQVLEEIIPLEELASISVGGIVFPISAE
>NZ_KE159707.1|WP_016322326.1|778168_778678_+|MarR-family-transcriptional-regulator
MDPTRRRIRKIDRDAQRFVAQALGNTDLSLSDYDMIHTVRHRPGVTQEELRRLYCLDKSTIARRAAKLEEAGYIVRRTSAADKRRKELFVTEKGDALREAKVEAEAEAFYFRWLTAELTEAELSVLVPLLDRLQLRSRDERRQEFVHLLEEYEGMSAEKGQCELLPDPT
>NZ_KE159707.1|WP_016322327.1|779141_779828_+|hypothetical-protein
MSGTLREWLDRELRDFEPVWKSFRGRQRRMYYIWMAAAVAGMTALGFGAGYEWTYVLRVHLPIGAGIAGFIWLCVLLTSRAATMKSVRKSFEKALSALSPSDQEAFARQDFGRTDFLNTFEDRFPARLLAGPDFWLYFRDVCQIYRTADMEKLGAREETVRVHCKSGGVRMRRKVGAGVSLTVDYRKDTAAARQGPDRVYLASWEQLQTAKDLIARYCPKAETLWREK

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_KE159707_3	3.1\|768338\|49\|NZ_KE159707\|CRISPRCasFinder	768338-768386	49	NZ_KE159707.1	768302-768350	1	0.98

1. spacer 3.1|768338|49|NZ_KE159707|CRISPRCasFinder matches to position: 768302-768350, mismatch: 1, identity: 0.98

agggtcggcgggggtggtctccccgtccttcttctcagggtcggcgggg	CRISPR spacer
agggtcggcgggagtggtctccccgtccttcttctcagggtcggcgggg	Protospacer
************.************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

86261 : 95228

Faecalibacterium_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016321654.1\|86261_87044_-	hypothetical protein	A0A2K9V2W4	Faecalibacterium_phage	6.1e-11	40.8
WP_016321656.1\|87797_88580_-	hypothetical protein	NA	NA	NA	NA
WP_016321657.1\|88609_89359_-	hypothetical protein	NA	NA	NA	NA
WP_016321658.1\|89360_89999_-	hypothetical protein	NA	NA	NA	NA
WP_016321659.1\|89995_91129_-	methionine adenosyltransferase	A0A2K5B278	Erysipelothrix_phage	8.6e-99	50.5
WP_040655215.1\|91118_91520_-	DUF3846 domain-containing protein	A0A2K9V361	Faecalibacterium_phage	4.8e-12	41.1
WP_016321661.1\|91971_92361_-	hypothetical protein	NA	NA	NA	NA
WP_016321662.1\|92350_92872_-	gamma-glutamylcyclotransferase	G3MAQ5	Bacillus_virus	4.0e-19	37.4
WP_040655219.1\|92864_93116_-	hypothetical protein	NA	NA	NA	NA
WP_016321664.1\|93126_94116_-	hypothetical protein	A0A1B1IUD7	uncultured_Mediterranean_phage	3.5e-48	37.4
WP_040655083.1\|94112_95228_-	DNA (cytosine-5-)-methyltransferase	M1NSK8	Streptococcus_phage	1.0e-80	44.8

DBSCAN-SWA_2

205526 : 208753

Streptococcus_phage(100.0%)

integrase,transposase

attL 199773:199785|attR 213564:213576

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
199773:199785	attL	NA	NA	NA	NA
WP_051147061.1\|205526_205823_+\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_081646293.1\|206030_206237_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	NA	NA	NA	NA
WP_155978974.1\|206203_206398_-\|transposase	transposase	NA	NA	NA	NA
WP_155978946.1\|206456_206918_-\|transposase	transposase	NA	NA	NA	NA
WP_016321774.1\|207091_208024_-	YafY family transcriptional regulator	A0A1B0RXM1	Streptococcus_phage	2.3e-12	30.3
WP_155978947.1\|208098_208500_+\|transposase	transposase	NA	NA	NA	NA
WP_155978948.1\|208612_208753_+\|transposase	transposase	NA	NA	NA	NA
213564:213576	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_KE159707.1|WP_016321673.1|99700_100450_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_KE159707.1|WP_016321673.1|99700_100450_-|hypothetical-protein

99700_100450_-

249 aa aa

AcrIIA11

hit_Aca_id	identity	query_coverage	hit_coverage
anti_CRISPR1292\|WP_016321673.1\|AcrIIA11\|II-A\|Verified\|Oscillibacter-sp.-1-3	1.0	1	1.0

2. NZ_KE159703

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_KE159703_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159703_1

593832-594012

Orphan

Consensus_repeat	Method
NCTTGCTTGCTTGCTTGCTTGCT	CRISPRCasFinder

4 spacers

The CRISPR arrays of NZ_KE159703_1

>merge|NZ_KE159703|1|593832-594012|CRISPRCasFinder
CAATTATCCCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTNNNNNNNNNNNNNNNCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCTTGCT

>NZ_KE159703|1|1|593832-594012|CRISPRCasFinder
CAATTATCCCTTGCTTGCTTGCT	TGCTTGCTTGCTTGCTT
GCTTGCTTGCTTGCTTGCTTGCT	TGCTTGCTTGCTTGCTT
GCTTGCTTGCTTGCTTGCTTGCT	TNNNNNNNNNNNNNN
NCTTGCTTGCTTGCTTGCTTGCT	TGCTTGCTTGCTTGCTT
GCTTGCTTGCTTGCTTGCTTGCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159703.1\|WP_016320922.1\|601375_601720_-\|PrgI-family-protein	unknown	unknown	gnl\|CDD\|378907
NZ_KE159703.1\|WP_016320925.1\|603412_603748_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_016320903.1\|577911_578211_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|171782
NZ_KE159703.1\|WP_016320916.1\|594213_594696_-\|DUF1273-family-protein	unknown	unknown	gnl\|CDD\|377733
NZ_KE159703.1\|WP_016320912.1\|584063_584339_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_040654548.1\|583406_583664_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|378900
NZ_KE159703.1\|WP_016320913.1\|584417_585143_-\|response-regulator-transcription-factor	unknown	unknown	gnl\|CDD\|223816
NZ_KE159703.1\|WP_016320911.1\|583650_584067_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274376
NZ_KE159703.1\|WP_016320921.1\|599052_601383_-\|DUF87-domain-containing-protein	unknown	unknown	gnl\|CDD\|274279
NZ_KE159703.1\|WP_155978876.1\|596048_598379_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
NZ_KE159703.1\|WP_016320914.1\|585293_591269_-\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|380138
NZ_KE159703.1\|WP_016320908.1\|582766_583093_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378047
NZ_KE159703.1\|WP_016320918.1\|595061_595919_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_155978877.1\|601874_602468_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_040654552.1\|598410_598980_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_016320924.1\|602473_603313_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_016320906.1\|580337_582029_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|238206
NZ_KE159703.1\|WP_016320915.1\|591352_593722_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225461
NZ_KE159703.1\|WP_016320917.1\|594801_595011_+\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379188
NZ_KE159703.1\|WP_016320909.1\|583105_583363_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_KE159703.1\|WP_016320922.1\|601375_601720_-\|PrgI-family-protein	gnl\|CDD\|378907	pfam12666, PrgI, PrgI family protein. This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 116 and 146 amino acids in length. This protein is found in an operon that is part of a Type IV secretion system.	5.15367e-33
NZ_KE159703.1\|WP_016320903.1\|577911_578211_+\|hypothetical-protein	gnl\|CDD\|171782	PRK12865, PRK12865, YciI-like protein; Reviewed.	0.00910311
NZ_KE159703.1\|WP_016320916.1\|594213_594696_-\|DUF1273-family-protein	gnl\|CDD\|377733	pfam06908, DUF1273, Protein of unknown function (DUF1273). This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	3.78463e-16
NZ_KE159703.1\|WP_040654548.1\|583406_583664_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|378900	pfam12645, HTH_16, Helix-turn-helix domain. This domain appears to be a helix-turn-helix domain suggesting that this might be a transcriptional regulatory protein. Some members of this family are annotated as conjugative transposon domains.	1.47147e-26
NZ_KE159703.1\|WP_016320913.1\|584417_585143_-\|response-regulator-transcription-factor	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.99579e-28
NZ_KE159703.1\|WP_016320911.1\|583650_584067_-\|hypothetical-protein	gnl\|CDD\|274376	TIGR02985, Sig70_bacteroi1, RNA polymerase sigma-70 factor, Bacteroides expansion family 1. This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.	1.28193e-07
NZ_KE159703.1\|WP_016320921.1\|599052_601383_-\|DUF87-domain-containing-protein	gnl\|CDD\|274279	TIGR02746, hypothetical_protein, type-IV secretion system protein TraC. The protein family described here is common among the F, P and I-like type IV secretion systems. Gene symbols include TraC (F-type), TrbE/VirB4 (P-type) and TraU (I-type). The protein conyains the Walker A and B motifs and so is a putative nucleotide triphosphatase.	8.82516e-21
NZ_KE159703.1\|WP_155978876.1\|596048_598379_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	5.2181e-07
NZ_KE159703.1\|WP_016320914.1\|585293_591269_-\|S-layer-homology-domain-containing-protein	gnl\|CDD\|380138	pfam18657, YDG, YDG domain. This presumed domain is found in a wide variety of bacterial cell surface proteins. This domain has a highly conserved YDG motif near its N-terminus. This domain is likely related to the pfam17883 domain.	1.95283e-12
NZ_KE159703.1\|WP_016320908.1\|582766_583093_-\|hypothetical-protein	gnl\|CDD\|378047	pfam08769, Spo0A_C, Sporulation initiation factor Spo0A C terminal. The response regulator Spo0A is comprised of a phophoacceptor domain and a transcription activation domain. This domain corresponds to the transcription activation domain and forms an alpha helical structure comprising of 6 alpha helices. The structure contains a helix-turn-helix and binds DNA.	9.17686e-36
NZ_KE159703.1\|WP_016320906.1\|580337_582029_-\|recombinase-family-protein	gnl\|CDD\|238206	cd00338, Ser_Recombinase, Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.	1.2922e-20
NZ_KE159703.1\|WP_016320917.1\|594801_595011_+\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	5.66865e-11
NZ_KE159703.1\|WP_016320915.1\|591352_593722_-\|hypothetical-protein	gnl\|CDD\|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	1.5303e-14

>NZ_KE159703.1|WP_016320915.1|591352_593722_-|hypothetical-protein
MDQNYIAPASALKKLKKARNLSQTVYLYGATGYGKTELVRQYLSGRRYTYLSCEELPWEDGALPRSEPGRQNRRVVVIDDLHRLKSEKLRQEILALEEREDIWLILVSRSPLPAWLMPRHIKSVFVVVSEDDLRMGRDEITAYLDARGVVYTEEDILYLQNTAEGNAYVLHHVALRMKEGQSPGPELRTEIREAFASYLENVVLVCWDSDLLEFLMQVSVVDEFTLELAEMISGNLHVTALLEQAGEAGNFITQEDGTYRLRPVLIDALRNRALKLYGRERVKDFKYNAALYYEMHDEVVPALRLFEECGKTERIKNLLIRNARMNPGNGHYYELRRYYFNMDEREIEDSPVLMAGMSMLHSMLMDDEKSEYWYEKLKAFATNAKGGVRREALSRLAYLDIGLPHRGSRDVLEIIKNIPALLFDKGNRLPEFSVTSNLPSTMNGGKDFCHWSPDDTKLAKTVGPLVERVLGSYGKGLVKAALGESYYEKGEDNYEVMSLLTRAQVEAGQGGTMEIAFAAVGVRVRLALLQGDSPAVRELLASFEQSVRENRAVQLLPNIQALRCRLALYEGDMDMVERWMKTAPDEDREFCSLERYRYLTKVRCYLANGEYTKAQALLEKLRYYAEQTGRPYVRMETGLLSAITKERVGGPWQEELAIVLKEVERYRFLRLITEEGAAVWPLFQREKKALQEAGTLNKDWLRRLLAEAEEVARRYPLYLKKRAAVAADFKGVALTILRLQADGLSVNRIAQRLDLKPDNVKYHIKENYRKLNVDNKTDALLAARSLGLL
>NZ_KE159703.1|WP_016320914.1|585293_591269_-|S-layer-homology-domain-containing-protein
MKRRILSIITALALCLSLCPTWALAAEADPALCPHHREHTEDCGYTAPTEGQPCGHQHTAGCYTLGVLPDADGGDPYEIGADTENPLDCQHIHDSECGYVQAEPGTPCGFVCKLCPIEDLVAALPDTVTEENADEVRAQLDQILTLFSELNEDEQEQIDLSRCYELQGALDGANDPAPITESVEYQEASWDGSQVTYESKTETCTLVENSAEAVTWTAGWYAVSGTVTISEPITVNGEVHLILTDGCTLTAEKGIVVTSTNSLTIYAQSENGGTLNATGTTDDSGNASAGIGGSTSSVDSGSITIHGGIINATGGVANNNFGNPNYGGAGIGGSTTSSGNGGNSGTIEIYGGTITANSGAGNVAGAGIGGGGGGNGKNGGDGSGITIYGGSITATFRGTGSGGAGIGGGAGNNGNGGAGNNIQINGGMVHATGGYLGAGIGGGGGVGKKSGDGTVTISGGTVTAVGGSYAAGIGGGGGYQYSNQWVSDSTTGGTGSVTITGGIVDASSPTDVDWEGYEGAPIGNGGNTNGTATVNKTTGIVFENGVGTVCGDVTFDGSYPVPADYTLNIPAGASLSGSGTLTGGGTFTADLSEDMVSVPTDLYYNGQDRSNDIKTRLSDGLTQGIAICGQTFTVSGWTVAVSRTDDLHYTATYTNESDTTKNFTKPITLQQSGTTLDGAVKTYNGETETKDFTASDTITVKATPTATGQAPANSAMFAASFTGPGAGQMAVFVGNTQVSEAVDAGADGTYTMTVSAADVLAAAGGPGTGITLTAKFVGNDNMADGAGTVDVSISAVAKIENGSTTTYVGNLDDAFKTENDGATITLLKDVTRTPVLDIQITCNLDLGGHTITCTGRTAISIWRNANLTIQGAGEVVSASNTALDVGGNVTLKGGTFTGGGSQSAGVNVNDESGSLSVTENVTIQNTGGGYGLAVSNAQSVQLSGGKYSGTAGAIVITSQSSSLTLGGLLAHSGDTRYAYFDESGIKPITGKLDDKELTGTVTVKKCNHTGEGVCEYTPNEGAETHAMTCLACGYAGAAEDCQYTYTPDSGGEHHITACQFCGRTKTEAHTYGSWTPEHNENAVTIRRSCENCGYTKTDGTFTVPAHVQTMQYGKPITLTCSSTLPGATFSWSLNGSTAEGTGASFTLPETLAVGEYMWNARVTWTGSDGETMSESGYLSVLPAPLTATGATAEGRAYDGTNSVEITGVTLAGILNGDDVSVDTTGLTGTLNGSNAGTYTNLTLPAMTLTGADAENYTVTRPAGAVPASVTIRKAAPLTPKTGDLAVANKQEHTYTYGLGALRPDVPEGISLGSTAVTYELGTVSLGSYYDSGAMIDGQTLTLPIKAVESDSETKIGTITVTIHTQNFEDMTATLDVRSVNKIIPTGGPNLSGNTLTYGQALGSITLSGNMKDGETPVPGKFEWSNPDNRPAVQENYAAAWIFKPDDNKTYAIVTGTALIQVLPAPIMGVVIVLDHTAFKYDGQPHRPGITSVTLNGTPLTADVDYTAAIPEGTEAGTYTVTLTGKGNYTGTATAVFIINPVEQKPLDQKDDDGHELRLEVETGLSTVPEALKTNEQFNTPGKIETALRTRVAEVMSNVGEQIAVFDVTLQYKDESGVWRNVDPNHFPAEGVTAVLPYPAGTGATGYTFTVQHLISSGAQAGTMETLAYTPTADGLQCKFSSLSPVAIGYQAATKPNPQPNPGGNSGGGGWSSSTYAVTVEKSEHGKVTSNRTNASNGSTVTLTVTPDSGYVLDTLTVTDSRGNEIKLTAQGGGKYTFTMPSRAVTVKASFVPLPDDTQKPCDGGADCPSHGFTDLGTVGTWYHEAVDYVLRNGLMNGYSNGTFGPNNNLTRAQFAQILFNKEGRPVVNYLLQYSDVAEGAWYTEAIRWATSRGIIGGYGNGNFGPNDNITREQLAVMLWRYAGSPAATDKELHFTDADKASGYALEALRWAVENGILNGYGDGLLGPQGQATRAQVAQMLKNFIENREPDA
>NZ_KE159703.1|WP_016320913.1|584417_585143_-|response-regulator-transcription-factor
MIYSVLTVGLSDKLVAALQNLIIQYDLNFTTSLTTREANRLLERRVFHLLIIGLDYLRTIQQADWLTDIRHISFVPLIVLSDTPEQDINNMVQLGADMCISGKPPFAAIANHACAQLRRYTEYNHYNDPARTETSSFQMGDIFIDPARRIVKVCRRLVNLRPREFSLLLYFMRNPNIVLNSEQICEHAWGMEGSYNQGVSHPVRLLRQAIEPDPINPVYIKTVYRVGYCFTAYCVETCDMC
>NZ_KE159703.1|WP_016320912.1|584063_584339_-|hypothetical-protein
MKRFSFFHVKYISLAEQAAAPEQGAAASFYSTENERFCRGDGQRAAAKTVEEYLLSPNKKILSKSLAKHPLALVIRIEGENKPLPEKGVTA
>NZ_KE159703.1|WP_016320911.1|583650_584067_-|hypothetical-protein
MSMEQNKRHAFDAYCKRLVKNEAVNIHLEYARQGKREAVFSELTQRELQSLCCTDRYAPERRVFTVLDMDFEIEDADLVRALAALTLKRRSIVLLAYLLEMKDDEIAQRLQMNRSTVQYQRTNTLEELRKLMEGYEYE
>NZ_KE159703.1|WP_040654548.1|583406_583664_-|helix-turn-helix-domain-containing-protein
MSMNNYRRNSKPHSRLLPYATIRAASEGDPDAVNAVLRHYEGYITRLAMRQLHDEYGNTYLCVDEAMRRRLEIKLITGILAFRAA
>NZ_KE159703.1|WP_016320909.1|583105_583363_-|hypothetical-protein
MRDIPYTSKLDHAEDGRPLALDYFILVRDGEPEQYGIKVIEKNSGAQSLAFDLTTEPERIYTLADKLSRNSVTPATLLDIVDDWL
>NZ_KE159703.1|WP_016320908.1|582766_583093_-|hypothetical-protein
MNTEQLLRNLGATGNLKGFRYAVHMIELAEQDPTAVTKVTKYLYPETARHFNVSPSVVERNLRTVIHICWSRGNREFFDEVAGTRLTYQPTNGMFLDMAAAFLRRREA
>NZ_KE159703.1|WP_016320906.1|580337_582029_-|recombinase-family-protein
MAEQMIQNISGVIGGEARVHVRRVVCLYRVSSVGQVEKDDIPMQKQSCREFVQRQTGWEIVKEFAEKGVSGFKKSAKDRDAIQEIQKLALQGGFDILLVFMFDRLGRRDDETPFVVEWFVKQNIEVWSAMEGQQRFDNHVDKLLNYIRYWQASGESIKTSMRVKTRIEQLTQEGHFTGGRAPFGYRAEKTGRMNKKNQDVRDLVIDPEDAEIVKLIFQKYVYEGYGALRLCRYFREQGIRRKDGGEVTVGMINRAVKNSIYIGVIHRGDSKSEVLPDLKIIDEELFFRALEIAGERKVQKREVPLTTRGRSLLVGNVYCGCCGARLMLATSGHKYQKKDGTVSTSTCSSYKCYNRTFAPGKCDGQTSFSVEKLDNLVEQIIRIQLSQIQKAPPQTLLAKQRSREVDLAKMKAKRLHDDYEQKQRAYQDLRAETLKVIQGNSRFSADLLNSLMDETAAQLKELESQMQAAELEVRETVSSAEQVQKEYTQLMNWAELYDNCSLEAKKMIVAQFVKAVRVKRGYELDIEFNVSFEEFQALYLEPEEKGRKRKRAGEILALAECAG
>NZ_KE159703.1|WP_016320903.1|577911_578211_+|hypothetical-protein
MLSPVLLSAVGTDGVHGYVREADLNPYVATRQDAIAYMSKLEENRVLPIYDKDGNVIGTFVLDGSFISGTAAKELERAKATAAAKPGAETRQSVIVKQV
>NZ_KE159703.1|WP_016320916.1|594213_594696_-|DUF1273-family-protein
MRNETCCFTGHRQIPPGERAEIASRLERVISDLYQRGIRYYGAGGALGFDALAARTVIRLRENCPGMKLILVLPCLTQTRGWRPEDIAEYERIKAQADKVVYTAQQYTPGCMHRRNRHLVDNSGVCVCYLTRNSGGTAYTVNYAKKQGVNVFNIAENIKL
>NZ_KE159703.1|WP_016320917.1|594801_595011_+|helix-turn-helix-transcriptional-regulator
MVDYSPLWDTMKKKGVSQYALIQAGVDRRTLDWLKKNKNITMLSLEKLCTILDCSPSDIVRFVKDDSQP
>NZ_KE159703.1|WP_016320918.1|595061_595919_-|hypothetical-protein
MLTWSTLDILSYGAGTPSTTLALMSCQNAQRGPPYPFPKVPVYDAVIFCDLHSEPGWVYEQAAFVAAACREANIPFYRLDADLYGDFTRNFGRARTACIPFWTLGDDGKKGKMPRQCTYDYKIKVIEKFVRYELLRYKPRERTLPLDVHAHSLHMGIMWEERRRAKESKQTLFVNRYPLVEMGWTRAECYAYNKIVWGLATRASCCLFCPYHTNYFYQYIREHEPGCYACALQVDALVETHQARPPLKSKLFLSKSRKRLRDLTEEDCQDKQTFLYFQTPVWNGF
>NZ_KE159703.1|WP_155978876.1|596048_598379_-|hypothetical-protein
MAAPFCISQFSYQERYFVKRGNIMPSPKEKPKGAKTKKSAGKVAARSQPAISAKQAAKLLKDKYVQQLDQHQPEGESIEVQAVDQVEGAGRWAVDELLTHERPRSDRQPDKRIKERPRDVPETPAPADAPASVPEGESPPPRQTSVSFRQRAGPLPKERAAQVKGQRPPAPPAEHSAPATPAAPADTPAHTMRIKERPVVRLKEQRTGTAAPSIKEKPSSLSNQSIPSIKSIRSIPPSNGRPAAGPSTYPTGKQLGAGPRSIRRSVSTAAKPASSPAAPGSSARLKREARRQTVGKPRQGLSQQPGPSAQGKTPGALNSVRSTGRDILPRTRASAKGSTPKIRGAVYRKGVSAPKAARAPIKSAVSRPVRGLRQNAQRRMTQRAVQQAGKAAKTSAVVLKKAAVAVTKAASALVSALASIIGGSILLLALVVVVVIAAIANSPFGLFFAQEPNAPGAVSVAQAVGTVNMAYNSRLELLQAGDYDTITLDGQAPDWADVLAVFAVKTAGADVDGLDVATLDSDRVNKLTAVFWDMTGIAVSEDTIDHPASGDTEAWTEKVLHITITPRTADDLRVSHAFSDYQNSALDELLADRAALSSLAGSLAITSADVREVLDALPDGLDPARREAVQTALQLVGKVNYFWGGKSRAIGWDSRWGQLTKVWAAGSSSTGTYRPFGLDCSGFVDWIFNNSQGYIIGHGGGVIMQHRYCTNISQTEAQPGDLAFYPDDSHIGIIVGRNEAGKLLVCHCASGQNNVVVTEFGASGFTVVGRPDIFGP
>NZ_KE159703.1|WP_040654552.1|598410_598980_+|hypothetical-protein
MGFTLEMMVPKTSFARRLEKQMDFDWLINQVKPYFPDAQDRTTASVRALCLILLEHLEPYGLRCGDRPLLASIYDNWRDNTAYMLLLQAVPGDIPAYRTLSDFGDIPVFEDVFYPVAGKLPPEVLRELLAHVLTNCAASRIAAEYPDQPLHYMNRLSKEEQAVEVERLARDYAEQFYQEVAAYRELAGQ
>NZ_KE159703.1|WP_016320921.1|599052_601383_-|DUF87-domain-containing-protein
MIKTLAAANKSEREPFRIPRSVQQSIPIQRVFRDGIWQTGRSRYSRTWRFADINYSVASHEDQQEMFLAYCGVLNSLPTGATAKITINNRRLNGTDFQHSVLMRLKGDELDRYRQEYNGILTEKALESNNLIQDKYITISVARKNIDEARTFFKRVDIDLSKSFGKLDSGAKPLDNHERLRIFHDFFRPSEERDFQFDLSAAMRRGHHFKDAIAPDGMQFKADHFELGGKVGRVLFLREYASYIKDRMITDLSDFSRNLMLSIDILPIPTNEAVKEMQSRILGVESDITRWQQKQNANNNFTATVPYELEQLRAENKEFLDDLSTRDQRMIFANVTLVHMADTLEQLDADTETLQAIGNESLCQFSVLRYQQEDGLNTALPYGLRRVRTTRTLTTESAAVLMPFRVQEIQDAGGIYYGVNAVSKNLLICNRKRLLNPHGFILGVSGSGKSFSMKEAITFIALSTSDDIIIIDAEREYGDLTRALGGAVIEISPNSPHHINPLEITRGYGTGENPVAMKSELLMSICEQQMGAGQLGAFHKSIIDRCTANVYHELIASGGKSRQPILSDWRNELKRQPEREAEELALASELFVEGSLNMFAHETNVDIANRIISFDLYEMGEQLKPTALNVTLETIQNRVAANRLAGKYTWVFVDEVYLFFRYYYSAQFLYKCWKRFRKYAAAMTAATQNVEECLRSDTARLMFANSEFLVLLNQAATDRAELAKLLNISTNQMSYITSAEAGHGLIRVGGSIVPFANEFPRDTELYRLMTTTPGDR
>NZ_KE159703.1|WP_016320922.1|601375_601720_-|PrgI-family-protein
MEIKIPKEVRQHKETIFFGLSVRQFVCAVLAVGTAVGVYFLLKTITGPETASWACIVAAAPVAVTGFFQYNGMTFEQFLWAFLKSQFLCAGPRVFQSENLYCAALTKKGVQDYD
>NZ_KE159703.1|WP_155978877.1|601874_602468_+|hypothetical-protein
MAVHQYNGPETGEECALLKIEGAYYKDYWLFLDVPLTAGLDSLDRFLREIWLECCGHMSAFFGKGHQEMKNSRKFSTFEPGEQFLHEYDFGDTTETLITVAGHTRREPQKAAVRLLARNIPPLIPCSRCGAPAAYVSTDNNIYKHKEPFLCKACAHESEIEEFSLPVTNSPRIGICAYYGDLDVYAFDAEKFAHREK
>NZ_KE159703.1|WP_016320924.1|602473_603313_-|hypothetical-protein
MSDNWIVGNLQSAFNTWNGKLTEIWSLITTTPEGFRGGTVWGTIVTINDAMKAVGYGLLVLFFAMSIFQTAASFRDFQRPEFVLRHFIRFVLAKLAVGSAMEIMTGIFSVCGGIVQTVMGGIGGMAAASITVPQEIVDAIEGVGFLASIPLWLVSLLGSLFITVMSFILILTVYGRFFRLYFYTALAPLPLASFAGEGTSFAGTAFLKSYVGVCLEGAIIVLACLIFSAFMSSGTPVVDTSLSAVTMSWQYIGETIFNMMVLVGLVKGAERIVKEMFGL
>NZ_KE159703.1|WP_016320925.1|603412_603748_-|hypothetical-protein
MKKTVETITARQRRAKRRYFTAVLTLALCTAMTCPAFAAGSDPLTIVNNLSDFIFSIIKAVGVIVLGWGIVQVGMSIQSHDASQRTQGFLCLFGGLMIAFAKEILTTIGAL

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Crispr_ID: NZ_KE159703_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159703_2

1141167-1141255

Orphan

Consensus_repeat	Method
CATAAATGCCGCCTTCATTTCCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_KE159703_2

>merge|NZ_KE159703|2|1141167-1141255|CRISPRCasFinder
CATAAATGCCGCCTTCATTTCCTGTTTTGGGATTGTCATCTCCTCCCTCATCCTTGCAGACGCTCCATAAATACCGCCTTCATTTCCTG

>NZ_KE159703|2|2|1141167-1141255|CRISPRCasFinder
CATAAATGCCGCCTTCATTTCCTG	TTTTGGGATTGTCATCTCCTCCCTCATCCTTGCAGACGCTC
CATAAATACCGCCTTCATTTCCTG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159703.1\|WP_016321427.1\|1142301_1143432_-\|phosphonoacetaldehyde-reductase	unknown	unknown	gnl\|CDD\|341461
NZ_KE159703.1\|WP_016321415.1\|1129140_1129857_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_016321416.1\|1129873_1130851_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_081646286.1\|1147345_1148629_-\|glycosyltransferase-family-2-protein	unknown	unknown	gnl\|CDD\|366154
NZ_KE159703.1\|WP_040654954.1\|1151122_1151689_-\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|240139
NZ_KE159703.1\|WP_016321417.1\|1130957_1133231_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_155978895.1\|1145574_1147158_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_081646285.1\|1139995_1140808_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|369777
NZ_KE159703.1\|WP_016321436.1\|1152983_1153931_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187545
NZ_KE159703.1\|WP_016321418.1\|1133420_1134677_-\|DUF4367-domain-containing-protein	unknown	unknown	gnl\|CDD\|379540
NZ_KE159703.1\|WP_016321428.1\|1143437_1145447_-\|phosphoenolpyruvate-mutase	unknown	unknown	gnl\|CDD\|274077
NZ_KE159703.1\|WP_016321432.1\|1149585_1149939_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|182223
NZ_KE159703.1\|WP_016321414.1\|1128237_1129089_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_040654948.1\|1135504_1136110_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_KE159703.1\|WP_155978896.1\|1148643_1149501_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159703.1\|WP_016321435.1\|1151691_1152996_-\|HAD-IIIA-family-hydrolase	unknown	unknown	gnl\|CDD\|133024
NZ_KE159703.1\|WP_016321419.1\|1134710_1135205_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|274357
NZ_KE159703.1\|WP_016321424.1\|1138073_1139927_+\|flagellin	unknown	unknown	gnl\|CDD\|236344
NZ_KE159703.1\|WP_016321423.1\|1137555_1137906_+\|carbon-storage-regulator	unknown	unknown	gnl\|CDD\|376847
NZ_KE159703.1\|WP_016321433.1\|1149964_1151095_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|133027

Protein	Function_ID	Function_description	E-value
NZ_KE159703.1\|WP_016321427.1\|1142301_1143432_-\|phosphonoacetaldehyde-reductase	gnl\|CDD\|341461	cd08182, HEPD, Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP). Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP) with either NADH or NADPH as a cofactor, although NADH is the preferred cofactor. PnAA is a biosynthetic intermediate for several phosphonates such as the antibiotic fosfomycin, phosphinothricin tripeptide (PTT), and 2-aminoethylphosphonate (AEP). This enzyme is named PhpC in PTT biosynthesis pathway in Streptomyces hygroscopicus and S. viridochromogenes.	1.63369e-147
NZ_KE159703.1\|WP_016321435.1\|1151691_1152996_-\|HAD-IIIA-family-hydrolase	gnl\|CDD\|133024	cd04181, NTP_transferase, NTP_transferases catalyze the transfer of nucleotides onto phosphosugars. Nucleotidyltransferases transfer nucleotides onto phosphosugars. The enzyme family includes Alpha-D-Glucose-1-Phosphate Cytidylyltransferase, Mannose-1-phosphate guanyltransferase, and Glucose-1-phosphate thymidylyltransferase. The products are activated sugars that are precursors for synthesis of lipopolysaccharide, glycolipids and polysaccharides.	4.99848e-71
NZ_KE159703.1\|WP_081646286.1\|1147345_1148629_-\|glycosyltransferase-family-2-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	8.36229e-34
NZ_KE159703.1\|WP_016321432.1\|1149585_1149939_-\|glycosyltransferase	gnl\|CDD\|182223	PRK10073, PRK10073, putative glycosyl transferase; Provisional.	5.45385e-34
NZ_KE159703.1\|WP_016321436.1\|1152983_1153931_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187545	cd05234, UDP_G4E_2_SDR_e, UDP-glucose 4 epimerase, subgroup 2, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup is comprised of archaeal and bacterial proteins, and has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.20165e-140
NZ_KE159703.1\|WP_016321418.1\|1133420_1134677_-\|DUF4367-domain-containing-protein	gnl\|CDD\|379540	pfam14285, DUF4367, Domain of unknown function (DUF4367). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 229 and 435 amino acids in length.	8.25504e-13
NZ_KE159703.1\|WP_016321428.1\|1143437_1145447_-\|phosphoenolpyruvate-mutase	gnl\|CDD\|274077	TIGR02320, Phosphoenolpyruvate_phosphomutase, phosphoenolpyruvate mutase. This family consists of examples of phosphoenolpyruvate phosphomutase, an enzyme that creates a C-P bond as the first step in the biosynthesis of natural products including antibiotics like bialaphos and phosphonothricin in Streptomyces species, phosphonate-modified molecules such as the polysaccharide B of Bacteroides fragilis, the phosphonolipids of Tetrahymena pyroformis, the glycosylinositolphospholipids of Trypanosoma cruzi. This gene generally occurs in prokaryotic organisms adjacent to the gene for phosphonopyruvate decarboxylase (aepY). Since the PEP phosphomutase reaction favors the substrate PEP energetically, the decarboxylase is required to drive the reaction in the direction of phosphonate production. Most often an aminotansferase (aepZ) is also present which leads to the production of the most common phosphonate compound, 2-aminoethylphosphonate (AEP). A closely related enzyme, phosphonopyruvate hydrolase from Variovorax sp. Pal2, is excluded from this model.	1.51455e-145
NZ_KE159703.1\|WP_040654954.1\|1151122_1151689_-\|SIS-domain-containing-protein	gnl\|CDD\|240139	cd05006, SIS_GmhA, Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).	1.75358e-65
NZ_KE159703.1\|WP_081646285.1\|1139995_1140808_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.89741e-16
NZ_KE159703.1\|WP_040654948.1\|1135504_1136110_+\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	6.35714e-36
NZ_KE159703.1\|WP_016321419.1\|1134710_1135205_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	1.92457e-18
NZ_KE159703.1\|WP_016321424.1\|1138073_1139927_+\|flagellin	gnl\|CDD\|236344	PRK08869, PRK08869, polar flagellin E.	6.10938e-47
NZ_KE159703.1\|WP_016321423.1\|1137555_1137906_+\|carbon-storage-regulator	gnl\|CDD\|376847	pfam02599, CsrA, Global regulator protein family. This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay. In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes. RmsA binds to RmsB regulatory RNA.	7.63993e-10
NZ_KE159703.1\|WP_016321433.1\|1149964_1151095_-\|glycosyltransferase	gnl\|CDD\|133027	cd04184, GT2_RfbC_Mx_like, Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis. The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.	2.28734e-43

>NZ_KE159703.1|WP_081646285.1|1139995_1140808_-|methyltransferase-domain-containing-protein
MPEDKICFSRLPDALAAKYKENYQLAKRFLSEANLCEIDDYTHFGKQLMRDLWVKKQLEQCEAGKSLLDAGAGDQRYKKYCSHLRYVSQDLCQYDGTGNGEGLQTEEWDVSQINIISDIIDIPVPDESFDYILCTEVFEHIPNPELAMKELSRILKKGGRLILSAPFTSVTHFAPYHYYPGINKYWYEEMCLRYGMKILEMCANGNYFRHIQLELERAAYVYKRHTGDHIREFDLLQIKETNRIMDRLAERAESSSELMNLGWFVLIEKC
>NZ_KE159703.1|WP_016321424.1|1138073_1139927_+|flagellin
MRIQHNIMALNAYRNYNTNTSALSKNLEKLSSGYKINRAGDDAAGLAISEKMRAQITGLNAAQKNVKDGISLVKTAEGAMQEIQDMLNRMDYLATQSANGTYDNEVDRANLQKEVDQLLDEIDRIAESSNFNGIKLLDGSLDTGAKAASTTWSDPADVSIGNAGQAHQLATTAVGHALRTDGVDRQDPTFTVDLTNVEFNAETANGFTINIGGVDIDVTKGADGTTALKKGDKLSGENLAKAIAAAVNATATTVKGTKAADATESAVLNGLEIDGLVYKASVEGSSVKFELQTADKDGAAILDQELKNDGTATIEQQGVTITDKAGDGTDGTFTGLDAMGHANTKINIGVAEKAGDLAHATIDLTGKIKDGTKLTIGDKTYVFQVGKDSKVTEAGDGEVLIDMKDVEADDAQLVDKAIAKLTNQENTWFRLESGKTGLLTAVEKVGTDGKPVYAGTGDITTTAGLQSNFQISQMTYTAADPGDASKSLQLQIGDTSDSYNQLQVKVGDMHRTALGLNGLNIGTAQDASNAIQKIKDAINQVSSVRGDLGATQNRLEHTANNLSVMAENIQDAESTIRDTDVAEEMMAYTKNNILVQSAQAMLAQANAVPQGALQLLG
>NZ_KE159703.1|WP_016321423.1|1137555_1137906_+|carbon-storage-regulator
MLCISMKPGEYFTVGGSTVVQLDRLTGDRVHLTVNAPREVPILRGAVLERSGGERPACVFDPPARPVRQLPWNGAKRAALADLRRTLEGMEDAPEVRILREKLDLIFSWPPEGGGE
>NZ_KE159703.1|WP_040654948.1|1135504_1136110_+|recombinase-family-protein
MAASTYGYIRVSTKEQNEDRQLIAMRELSVAEKNIFMDKQSGKDFRRPQYQRMVKKLKPDDLIYVKSIDRLGRNYEEILEQWRILTREKRVDIAVLDMPLLDTRRGKDLMGTFLSDIVLQVLSFVAENERSNIRQRQAEGIAAARARGVRFGRSPHPLPENFRQIHRDWRGKKLTLKEAADACAMPVGTFYAKAVRLENDN
>NZ_KE159703.1|WP_016321419.1|1134710_1135205_-|sigma-70-family-RNA-polymerase-sigma-factor
MEDRNTWEAAVEQLYKELYPALHIYALRVLGESALAEEAIQDAFCIACAKREQFLASSDPRRWIMCTLKHVCQNMLRTQARLKKLLLSLDPGRCLAAGTTDLVSVDVLFGDLSDSEDFRLLKRIALDRCTMLEVAEELGISVESCKKRVQRARKRLQEKIEACI
>NZ_KE159703.1|WP_016321418.1|1133420_1134677_-|DUF4367-domain-containing-protein
MTQSEKVRQKRLKALERTSSADLEALLLLDFQSQETGETEMDEILRAAEILAARQHRQGDGGADRAWAEFLEKYRPFAGGSSLYESAEAPSASAVAVQPRPAPSPSLRRRMRRLARQASHPIWYRLLRTAACLALCLLLSGGLLLTFSPEARAVFSGWVREICGDHLEYRYASSDEAAGTDNQAVIYRPAWVPEGCRLTNISDQGASVSLLYETANGYGLVFQYFPTSSGAFSIYMEGPSETVTVRGNPADLYLSLVEGNTNGLVWGDTEAELLMSIFADLPREDLLRIAESIRPVSGEQPPNRPLWFPDSYTLLNSGDGISRIGILCTNDDGGRLCYTYATAGSADREKSWAEITEAAAGLVAEEVLINGLPAQLYRQPDGTGHLVWTNPFGDLYWISGPLTAQEFIQMAESVIMGS
>NZ_KE159703.1|WP_016321417.1|1130957_1133231_-|hypothetical-protein
MEQKKRRENVAAGIVGAFLGSLIGVVCTVIIGQMGYVASISGLVMAVCALKGYEMLGGMLSKKGAAVSSVLILLMTFFAHRLTWAIAVSSELDWGILEAYRSISFLLERGMLKSAAYWGDLVMLYLFTLLGAVPTILGGLRNTGAPELPPPPASPEASAAAGEADFYPAGKGWLRPLRFSFLFALLPGLAVGVALLIIAVRRDAPIPLTMAALLAILSSFVAMIFALPISRINQAEAFLFVRTAGHLWQVNLNALNVMDTYRFTEKAARLRALRWENLSQTEQERAKASILRAVSLLTSGQVLPGSSLSLVVRPLTDFELIKEDQWSWQGQYSLQNGRQKKIRIAKVYPNFAPVYGLEPPQEPAPWRWGLCVLALVLALALGAAGYGLGALLDGSLSGGAASPGRTGSAGQTGSAAVTARTPKSEVHRYETDGVYYLVDGAFQVTDINTFHDSVTNTDFTLTVQTGADEDAAVDTLLQPISDYRTSPQYDYFQFAHAGAEETLVPLTAADGTEYRYEILTLYLKDGSAVHVGTALAEDGLLVTVEARQKSGGSGKKSEDVRGTILFMLENLQRTGSAQVEITEENYQSLFHLAEELDYQYTAAGYIKAPHDMFGRDAFVDAHVPFGSPVYLDDGYTLRSAAHGMEATVTIAAGEDARDVVDQAYAALEASGADLYPESVSDTTYFPEYDTAVKQAAYLEAGAPRIAILYADCKQEGYYLSAQITYLPEQMDEDYPALRLELSSAYALTLPEIEPLAP
>NZ_KE159703.1|WP_016321416.1|1129873_1130851_-|hypothetical-protein
MKKYLITAAAVLCLLLTACGPMAKTEELSDEEVVNTLIQAFQQGDYEGIKPYISDDNPLHQLFSGTDEAVGGEMAPVYKACLEKTGALTCAAKAVEGKETWGTVEVTLAAPNYYDAFHAAMAAALEEDVETGSGAFYDMPGWMSKALEGEGGATEETWELHVGNRDGAMVMDSNTNRQFFTALCGGLKSYLNASMTTCTFPDGTVWVLAAQGDEIVAIIRTESVSGASQYALEDMEAVIQAFEAPYETLEGIFAHGEVQGDLLISRLGVDMETASSFTLVQMGLIDKQTTAGSNGHLSLSATISGFTRDGAQCVTETFKPAQPET
>NZ_KE159703.1|WP_016321415.1|1129140_1129857_-|hypothetical-protein
MLGRLFNKISGTGLVLLLIGTVLLGFSLRDTVISFKPARSFDDVLSGDVSAGDHVSGRVPYLLDSFASMQTWTENRSNNSRTAKKTSSQYYVLPGGRGYLGLTVHSSNFSPANKLVDQTYGYLSGGAAPTAELELDTRVVKMEEELAEMFRQTLREDYGFSDTDIDTMGPLLMAEPRAFGTIRVFCGVGGALFLLGAVLLVRYWRKSTANSRRAREARAARAAQEAPAARPSYDPEIR
>NZ_KE159703.1|WP_016321414.1|1128237_1129089_-|hypothetical-protein
MDKFLGILWYIVVLAIAVTVAGWRYNMGPVIWMRRSRGRARALEDDASRRDLVERVRQRLPQASDQNVVFSLQVESHTSGSSRMRVTTYTYYYKVFVADADCLWVLPFSYDKKTRGYELGDPVPLTRDLIQRVSLAGKRGKKLTVSFTLKPELGLDKIVMVLEPLQFQRNKFYPFDFLQEGACAKAMDLTEKLALAACGLTSEDLEETRLEDECGNYAVAAGLCGFCGIIAASVGNTLLLPLALFAAALGCFGVMLSKKQMPKISLVIVIVEAVVAFLLFRLP
>NZ_KE159703.1|WP_016321427.1|1142301_1143432_-|phosphonoacetaldehyde-reductase
MEQTMMRTYGDYRVLEEYLQKIGTRRLFLVCGSSIQKLRVDGCFDALNKRIPVIRFSGFTPNPKYEDAVRAVEAFRRSNCDAIIAVGGGSAMDIAKCVKLWAALRAEDGFLNQTPYPNDFPLLAVPTTAGTGSEATRYAVIYYHGEKQSLSCEECIPSAVLLDPSLLESLPDYHRKASMLDALCHGIESFWSVHAAKKSREFSRRAICGILENLELYLQNHPKGNAGMLEAAYLAGKAIDLTQTTAGHAMCYKLTTLYRIAHGHAAALCVSKLWPYLAERSRGTELEDTLSELAAAMGCGTIPESIGKFERLLSSLHLETPIPRPEDFLILQNSVNPARLQNTPIVPGMEDILALYRQILSKGGAAECRQRHLRKF
>NZ_KE159703.1|WP_016321428.1|1143437_1145447_-|phosphoenolpyruvate-mutase
MKALILNSGMGTRMAPLTDRQPKCLTELSPGTTILGRQLQMLAAVGIAEAVITTGPFPGVLEEYCTQLKLPLQYTFVSNPDYRTTNYIYSIYLAQEALQDDILLLHGDLIFEQEVLRQVLESRESCIVTSSTAPLPEKDFKAVILENRVEKVGVEFFDSALAAQPLYYLKKGDWLVWLEQISRFCQTGQVTCYAEKALNRITKDIALRPLDIRNMLCGEVDQPEDLAVMRARLQAAENRNVYMCFSTDMLHGGHMSILQRAAGLGRLTVGVLSDEAVASYKRFPLLPCRERKALFASIKGVERVIEQPELSYKKILLEWKPDIVVHGDDWREGFQRPLREEVLDVLNSYGGRLVEFPYSKETRYEDLERRFRAELSLPDNRRGRLRKLLAMKGLITAMEAHDGLSGLIVENTAVHENGRSYSFDAIWVSSLCDSTAKGKPDMELVDKTSRFRTIDDLTEVTTKPIIFDGDTGGLAEHFVYTVRSLEKLGVSAVIIEDKQGLKKNSLFGTEAAQAQDSIASFSEKIAAGKRAQKSADFMIIARIESLILEQGMEDALARAAAFVQAGADGIMIHSRRKEPDEIFEFAERFRRQDGHTPLVVVPTSFHAVTEAEFKRRGVNVVIYANQLMRSQVPAMRRTAESILKHHRALEADETLMPFQEIIRMIPAEL
>NZ_KE159703.1|WP_155978895.1|1145574_1147158_-|hypothetical-protein
MLFAYFSLDQKQITGIFDRQVTMDSQCGYPCFPAKELPNAGCGVVILSSFYYREEILAELRPLGLRIIDPYEELEKQGIELIAPLDQYSPESSLTLNHFYRKYLESRDGPGRNRALHDVLQAAVELKDFVMVRRICAENAAPKDPLLLEVQAKTENLLQTIRRRIQDRKQKDVMVFWTDAVSYYLLPQMPLMLEKSKHSCFFRRAYTHTPFTHQSLSAIFTKMLPIDDYERAKGPVCRENSPLIQYLEDRDYDIKFIAHLKSSMDSRYFLETSLSASCNVKWWAGLERWLSSEKPCFYIFHILEESHEPNISPDLQAFTDTRFKSPLQERQRQTALAYLDQCLALYSEMAGDTVQVFLSDHGQYIFPLPNWSEERLHAYCFALGKNIPERTVSRFFPYRNFDCFAKWLVEPEKYPLEDACADEVIFQDTDFYNPVRISLFIRHGIPKEGLAIRGVLNDTCRYTVNALGEETFFRYAEDGTEEPAVLEDPRLRAELQKKCGTNFLDIYQLDRFQHTRKLYEYLKSTQE
>NZ_KE159703.1|WP_081646286.1|1147345_1148629_-|glycosyltransferase-family-2-protein
MNSGNFLLSIIVPVYNAAPHLRECVDSILHQTYENLEIILMADGGSTDNSTEICEEYAEKDARIKVLHRPHETLPAARKAGVAAANGEYVAYVDSDDWIDADAYERILESMGDQSPDVLVHGFIREYADKGVVCQYGLPSGYYDENGIAAEIYPHLLEIRFPYQWELLPGYWRANGHDRTRRGPALQAPQLYIYSGVWSKVFKRNILKRSQMAVPDDLTEGEDLVCTVHTLFSAHSVMVTDFAPYHYRFRTDSLARTDHGRPYQEHQLLFRSLHAALSKRPLTGLYRMRLSRYLMDRVLLNRYERFLTGRFSDVLFGSLDGRRVALYGAGRFGQEIYRKTSQVFPNRITLWVDRDYESARMNGLPAEPVQALQSKEYDVVVTALVNEEICEQIKQDLIAMGIDPEKIRYATASPEVLKAVEAVFLDQ
>NZ_KE159703.1|WP_155978896.1|1148643_1149501_-|hypothetical-protein
MMREVYPRLLSLRYADQLAVSPGTGYDAAVKTGQGFRRCHQPEIYSSVWSKLVKRELLRQTQEMVPDHVTMGEDLVCTVYTLLFARSVTVTDYAPYHYQMRDDSASLSNVSFQPYQAMFEAADSALQNSPMRETHLMQLYAVLLDYVLLTQYEAFLQDEFSNFPFGNLNGRRMALYGAGKFGREIFRKTKALFPDRITLWVDQNYKTYQAADLPVEPVSRLLEAEYDIVVIALINEALCEEIKKHLTAVGVDGEKIRYVSVSLELLDATKRILQKQRNRLNKTKD
>NZ_KE159703.1|WP_016321432.1|1149585_1149939_-|glycosyltransferase
MKNDLLLSVIVPVYNVAPYLHKCLDSILCQTYRNLEIILVADGGSTDGSTEICEAYAAKDARIKLLHRPHEGLVSARKAGVAAASGQYAAYVDGDDWIDADAYERLLSLVTDHEPDV
>NZ_KE159703.1|WP_016321433.1|1149964_1151095_-|glycosyltransferase
MTDISIVLPVYNGSKYLSLSIESILAQTYQNWELIIVNDCSTDSSLAIAEKYAQKDRRIRILSNSENQRLPRSLNIGFANAAGRYFTWTSDDNLFHSRALETMASYLDAHEQCGMVYCDMDYIDADGNVISNTQNTSHNFYLSNCIGACFMYRREAADTVGGYDPDKFLVEDYDYWLRISFQYPVERIPQILYSYRHHSGNMTSVYEKKIADNVFNLRVEYLDRISEHLSAREFSLYCTGLLLNKPDAGPKIEEIAFRRGLKYDAAKILSHSAFDADKKFIIFGAGVIGQQALRMIGRTRVSYFADNLKYGQTVDGIAVISAERVKDLQHLYNVMIAVDYSKSAEIIEQMERIGVLNYSLFLLIKDRLERLWNPAL
>NZ_KE159703.1|WP_040654954.1|1151122_1151689_-|SIS-domain-containing-protein
MDFTKAIHEYLEDEMNTLRALDVESLNQALNLLMEAFENGNTVYVFGNGGSAATASHFQNDFNKGVSEHTAKKFNFLCLNDNVATVMAVANDIGYDEIFRFQLRGHLKPGDLILAISGSGNSKNVLNAVEYAKEQGSQVIGLTGFRGGKLKELADISLHAPVESMQITEDIHLIFNHLMMRTLSRALS
>NZ_KE159703.1|WP_016321435.1|1151691_1152996_-|HAD-IIIA-family-hydrolase
MQAVIMAGGKGTRLSGLTRDEIPKPMVPILGKPLLLWQMDALKQHGITNILLVIGHLGHVIQNYFGNGRTFGLHIQYYHEEVPLGTAGALARIRPMLEETFFLIYGDVLFDIDLSRMERFHSQKQSAATLFVHPNSHPFDSDLVEMDAEQRVLRFDSKQNLRSGWYDNCVNAGLYLMDRGICDELPDQERIDLEADVLMPLCRRKGAIYAYPSPEYIKDIGTVERIRAAEADIKSGIAAARNLKRPQRAVFLDRDGTVNVKKGLISGTEQFELEKNAAEAIRKINQSGYLAIVVTNQPAVARGLCGVEEIEKIHRKMQTLLGREGVFLDAVRYCPHHPDKGYPEENPAYKIPCRCRKPDIGMLEDCAEKYNISLADSWLIGDTTVDIQTGKNAGTKTALVLTGDAGRDKKYNAEPDLICADILDAAERILGKGL
>NZ_KE159703.1|WP_016321436.1|1152983_1153931_-|NAD-dependent-epimerase/dehydratase-family-protein
MRALVAGGAGFIGSNLIDALLAAGHSVICIDNFFIGSRQNIAHLEHHPRFQFYEQDLSELEPLIHIFEKEPVDFVFHMAANSDIQASAKAPEVEYRNTYTTTFNVLEAMRISGVKNLFFCSTSAVYGDTQGKKTDENYAPLMPISYYGACKLGCEGLISAFSHMNGFHSLVFRFPNVIGPRLTHGVIFDFVNRLREDSESLTILGDGQQRKPYLYVADLVDCILRFTENLPEGVTLYNVGGETQSVVSEIAEIVCREMGLPDVAFHYTGGRGGWKGDVPIFAYDLSKIHSAGWSAAMTSDEAVTQTVRDILSCRQ

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Identity
NZ_KE159703_1	1.1\|593855\|17\|NZ_KE159703\|CRISPRCasFinder	593855-593871	17	NZ_KE159703.1	593997-594013	1.0
NZ_KE159703_1	1.1\|593855\|17\|NZ_KE159703\|CRISPRCasFinder	593855-593871	17	NZ_KE159703.1	594001-594017	1.0
NZ_KE159703_1	1.1\|593855\|17\|NZ_KE159703\|CRISPRCasFinder	593855-593871	17	NZ_KE159703.1	594005-594021	1.0
NZ_KE159703_1	1.1\|593855\|17\|NZ_KE159703\|CRISPRCasFinder	593855-593871	17	NZ_KE159703.1	594009-594025	1.0
NZ_KE159703_1	1.1\|593855\|17\|NZ_KE159703\|CRISPRCasFinder	593855-593871	17	NZ_KE159703.1	594013-594029	1.0
NZ_KE159703_1	1.1\|593855\|17\|NZ_KE159703\|CRISPRCasFinder	593855-593871	17	NZ_KE159703.1	594017-594033	1.0
NZ_KE159703_1	1.2\|593895\|17\|NZ_KE159703\|CRISPRCasFinder	593895-593911	17	NZ_KE159703.1	593997-594013	1.0
NZ_KE159703_1	1.2\|593895\|17\|NZ_KE159703\|CRISPRCasFinder	593895-593911	17	NZ_KE159703.1	594001-594017	1.0
NZ_KE159703_1	1.2\|593895\|17\|NZ_KE159703\|CRISPRCasFinder	593895-593911	17	NZ_KE159703.1	594005-594021	1.0
NZ_KE159703_1	1.2\|593895\|17\|NZ_KE159703\|CRISPRCasFinder	593895-593911	17	NZ_KE159703.1	594009-594025	1.0
NZ_KE159703_1	1.2\|593895\|17\|NZ_KE159703\|CRISPRCasFinder	593895-593911	17	NZ_KE159703.1	594013-594029	1.0
NZ_KE159703_1	1.2\|593895\|17\|NZ_KE159703\|CRISPRCasFinder	593895-593911	17	NZ_KE159703.1	594017-594033	1.0
NZ_KE159703_1	1.4\|593973\|17\|NZ_KE159703\|CRISPRCasFinder	593973-593989	17	NZ_KE159703.1	593997-594013	1.0
NZ_KE159703_1	1.4\|593973\|17\|NZ_KE159703\|CRISPRCasFinder	593973-593989	17	NZ_KE159703.1	594001-594017	1.0
NZ_KE159703_1	1.4\|593973\|17\|NZ_KE159703\|CRISPRCasFinder	593973-593989	17	NZ_KE159703.1	594005-594021	1.0
NZ_KE159703_1	1.4\|593973\|17\|NZ_KE159703\|CRISPRCasFinder	593973-593989	17	NZ_KE159703.1	594009-594025	1.0
NZ_KE159703_1	1.4\|593973\|17\|NZ_KE159703\|CRISPRCasFinder	593973-593989	17	NZ_KE159703.1	594013-594029	1.0
NZ_KE159703_1	1.4\|593973\|17\|NZ_KE159703\|CRISPRCasFinder	593973-593989	17	NZ_KE159703.1	594017-594033	1.0

1. spacer 1.1|593855|17|NZ_KE159703|CRISPRCasFinder matches to position: 593997-594013, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

2. spacer 1.1|593855|17|NZ_KE159703|CRISPRCasFinder matches to position: 594001-594017, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

3. spacer 1.1|593855|17|NZ_KE159703|CRISPRCasFinder matches to position: 594005-594021, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

4. spacer 1.1|593855|17|NZ_KE159703|CRISPRCasFinder matches to position: 594009-594025, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

5. spacer 1.1|593855|17|NZ_KE159703|CRISPRCasFinder matches to position: 594013-594029, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

6. spacer 1.1|593855|17|NZ_KE159703|CRISPRCasFinder matches to position: 594017-594033, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

7. spacer 1.2|593895|17|NZ_KE159703|CRISPRCasFinder matches to position: 593997-594013, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

8. spacer 1.2|593895|17|NZ_KE159703|CRISPRCasFinder matches to position: 594001-594017, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

9. spacer 1.2|593895|17|NZ_KE159703|CRISPRCasFinder matches to position: 594005-594021, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

10. spacer 1.2|593895|17|NZ_KE159703|CRISPRCasFinder matches to position: 594009-594025, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

11. spacer 1.2|593895|17|NZ_KE159703|CRISPRCasFinder matches to position: 594013-594029, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

12. spacer 1.2|593895|17|NZ_KE159703|CRISPRCasFinder matches to position: 594017-594033, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

13. spacer 1.4|593973|17|NZ_KE159703|CRISPRCasFinder matches to position: 593997-594013, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

14. spacer 1.4|593973|17|NZ_KE159703|CRISPRCasFinder matches to position: 594001-594017, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

15. spacer 1.4|593973|17|NZ_KE159703|CRISPRCasFinder matches to position: 594005-594021, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

16. spacer 1.4|593973|17|NZ_KE159703|CRISPRCasFinder matches to position: 594009-594025, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

17. spacer 1.4|593973|17|NZ_KE159703|CRISPRCasFinder matches to position: 594013-594029, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

18. spacer 1.4|593973|17|NZ_KE159703|CRISPRCasFinder matches to position: 594017-594033, mismatch: 0, identity: 1.0

tgcttgcttgcttgctt	CRISPR spacer
tgcttgcttgcttgctt	Protospacer
*****************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

501536 : 508242

Erysipelothrix_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016320820.1\|501536_501905_+	type II toxin-antitoxin system PemK/MazF family toxin	A0A2P0ZKX3	Lactobacillus_phage	6.4e-11	35.1
WP_016320822.1\|502148_503753_+	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	1.2e-77	35.7
WP_081646240.1\|503749_504571_+	hypothetical protein	C7F8K5	Bacillus_phage	6.0e-09	25.7
WP_016320824.1\|504567_505128_+	recombinase family protein	Q6DMY0	Streptococcus_phage	1.9e-27	49.6
WP_016320825.1\|505134_506772_+	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	6.6e-92	41.5
WP_016320826.1\|506768_507518_+	metallophosphoesterase	A0A2D0ZMA7	Rhodococcus_phage	1.7e-10	28.0
WP_016320827.1\|507678_508242_+	RNA 2'-phosphotransferase	A0A2R2ZGT8	Clostridioides_phage	7.4e-51	56.3

DBSCAN-SWA_2

985396 : 991573

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016321281.1\|985396_986578_-	phosphoribosylaminoimidazolecarboxamide formyltransferase	Q58MG4	Prochlorococcus_phage	1.8e-22	25.6
WP_016321282.1\|986590_987166_-	SMI1/KNR4 family protein	NA	NA	NA	NA
WP_016321283.1\|987177_987774_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.2e-19	35.5
WP_016321284.1\|987770_988823_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	4.0e-66	45.9
WP_016321285.1\|988889_990314_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.3e-13	26.3
WP_016321286.1\|990313_991027_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A127KMU1	Cyanophage	2.2e-39	40.0
WP_016321287.1\|991075_991573_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.8e-17	39.6

DBSCAN-SWA_3

1149964 : 1156052

Caulobacter_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016321433.1\|1149964_1151095_-	glycosyltransferase	A0A167RG86	Powai_lake_megavirus	5.0e-14	31.7
WP_040654954.1\|1151122_1151689_-	SIS domain-containing protein	A0A067XQR2	Caulobacter_phage	3.7e-26	37.9
WP_016321435.1\|1151691_1152996_-	HAD-IIIA family hydrolase	I7I009	Enterobacteria_phage	5.4e-12	28.3
WP_016321436.1\|1152983_1153931_-	NAD-dependent epimerase/dehydratase family protein	A0A0E3FNQ3	Synechococcus_phage	2.2e-31	34.1
WP_016321437.1\|1153944_1154931_-	hypothetical protein	A0A067XQL1	Caulobacter_phage	8.4e-34	33.5
WP_016321438.1\|1154927_1156052_-	hypothetical protein	A0A2K9L0K0	Tupanvirus	1.1e-08	31.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_KE159711

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_KE159711_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159711_1

55597-56569

TypeI

I-C

Consensus_repeat	Method
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	PILER-CR
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CRT

14 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_KE159711_1

>merge|NZ_KE159711|1|55597-56569|PILER-CR,CRISPRCasFinder,CRT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAATCTGCCCTTCCATAGAGGGTAATGATTGTGGGGGTGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATCTGGAGGAGAAGTTTAAGGTGAAGCCAGCCCTAGGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATGGTTTGTGGCTGATGTCCCTATTGTGGCTGATGTGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATTGGGTCCGATATTCATTGGGGTCTTTGAAAACCGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATGCCTCTCACATCTTGAATGAAAACACTCCGAACGGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATCCCGGCAATCGTGGAATTAACCCGGACCAGGGTGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATCCAAGACCATGCAGGACAAGGTGATTGAGGGAAAGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATGGCCTCTCAAGTACTCAATGGCCATGTTGAGCTTGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATGGGGAGCTCTCCCAAAGATAACTCGGCTTAGGGTCGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATTTTCGTTGCTCTTTCCGGAGGTATTTGTCGTCCGAGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATATCCGGAGGACCTTGGCCAAGGGACATGAAGCAGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATCCAGATGGGGTAACAGCAGCAGCTTTTGAGGAGGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATATTTCCTTTCTTAGTTGTTTTTTGGTATCCAACGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATGTGAAGACCCGGTCGTCGGCCTTGGCGACGATGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATT

>NZ_KE159711|1|1|55597-56568|PILER-CR
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTGCCCTTCCATAGAGGGTAATGATTGTGGGGGT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTGGAGGAGAAGTTTAAGGTGAAGCCAGCCCTAGG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GGTTTGTGGCTGATGTCCCTATTGTGGCTGATGT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TGGGTCCGATATTCATTGGGGTCTTTGAAAACC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GCCTCTCACATCTTGAATGAAAACACTCCGAACGG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCCGGCAATCGTGGAATTAACCCGGACCAGGGTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCAAGACCATGCAGGACAAGGTGATTGAGGGAAA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GGCCTCTCAAGTACTCAATGGCCATGTTGAGCTT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GGGGAGCTCTCCCAAAGATAACTCGGCTTAGGGTC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TTTCGTTGCTCTTTCCGGAGGTATTTGTCGTCCGA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATCCGGAGGACCTTGGCCAAGGGACATGAAGCAG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCAGATGGGGTAACAGCAGCAGCTTTTGAGGAGG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATTTCCTTTCTTAGTTGTTTTTTGGTATCCAAC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GTGAAGACCCGGTCGTCGGCCTTGGCGACGATG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT

>NZ_KE159711|1|1|55597-56569|CRISPRCasFinder
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTGCCCTTCCATAGAGGGTAATGATTGTGGGGGT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTGGAGGAGAAGTTTAAGGTGAAGCCAGCCCTAGG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GGTTTGTGGCTGATGTCCCTATTGTGGCTGATGT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TGGGTCCGATATTCATTGGGGTCTTTGAAAACC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GCCTCTCACATCTTGAATGAAAACACTCCGAACGG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCCGGCAATCGTGGAATTAACCCGGACCAGGGTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCAAGACCATGCAGGACAAGGTGATTGAGGGAAA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GGCCTCTCAAGTACTCAATGGCCATGTTGAGCTT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GGGGAGCTCTCCCAAAGATAACTCGGCTTAGGGTC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TTTCGTTGCTCTTTCCGGAGGTATTTGTCGTCCGA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATCCGGAGGACCTTGGCCAAGGGACATGAAGCAG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCAGATGGGGTAACAGCAGCAGCTTTTGAGGAGG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATTTCCTTTCTTAGTTGTTTTTTGGTATCCAAC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GTGAAGACCCGGTCGTCGGCCTTGGCGACGATG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAATT

>NZ_KE159711|1|1|55597-56568|CRT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTGCCCTTCCATAGAGGGTAATGATTGTGGGGGT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTGGAGGAGAAGTTTAAGGTGAAGCCAGCCCTAGG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GGTTTGTGGCTGATGTCCCTATTGTGGCTGATGT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TGGGTCCGATATTCATTGGGGTCTTTGAAAACC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GCCTCTCACATCTTGAATGAAAACACTCCGAACGG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCCGGCAATCGTGGAATTAACCCGGACCAGGGTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCAAGACCATGCAGGACAAGGTGATTGAGGGAAA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GGCCTCTCAAGTACTCAATGGCCATGTTGAGCTT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GGGGAGCTCTCCCAAAGATAACTCGGCTTAGGGTC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TTTCGTTGCTCTTTCCGGAGGTATTTGTCGTCCGA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATCCGGAGGACCTTGGCCAAGGGACATGAAGCAG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCAGATGGGGTAACAGCAGCAGCTTTTGAGGAGG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATTTCCTTTCTTAGTTGTTTTTTGGTATCCAAC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GTGAAGACCCGGTCGTCGGCCTTGGCGACGATG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159711.1\|WP_155979098.1\|65101_65821_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_KE159711.1\|WP_040656198.1\|61915_63127_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238426
NZ_KE159711.1\|WP_016323966.1\|66983_68501_-\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|341253
NZ_KE159711.1\|WP_016323944.1\|40978_41599_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_KE159711.1\|WP_016323951.1\|52601_53453_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|187820
NZ_KE159711.1\|WP_016323948.1\|47706_50082_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_KE159711.1\|WP_016323952.1\|53442_54105_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|273040
NZ_KE159711.1\|WP_016323965.1\|66001_66969_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|187712
NZ_KE159711.1\|WP_016323963.1\|64857_65091_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|223314
NZ_KE159711.1\|WP_016323953.1\|54101_55133_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NZ_KE159711.1\|WP_016323958.1\|60823_61042_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|223314
NZ_KE159711.1\|WP_081646417.1\|61158_61968_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_KE159711.1\|WP_016323961.1\|63132_63807_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NZ_KE159711.1\|WP_016323946.1\|42781_46288_-\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|306825
NZ_KE159711.1\|WP_016323950.1\|50812_52585_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	pfam09709_cas8c_CAS-I-C	gnl\|CDD\|378245
NZ_KE159711.1\|WP_016323954.1\|55137_55428_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_KE159711.1\|WP_016323957.1\|59174_60710_-\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NZ_KE159711.1\|WP_016323949.1\|50084_50813_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NZ_KE159711.1\|WP_051147130.1\|46865_47285_+\|small-multi-drug-export-protein	unknown	unknown	gnl\|CDD\|377692
NZ_KE159711.1\|WP_016323962.1\|63781_64861_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238426

Protein	Function_ID	Function_description	E-value
NZ_KE159711.1\|WP_155979098.1\|65101_65821_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	0.000609084
NZ_KE159711.1\|WP_040656198.1\|61915_63127_-\|hypothetical-protein	gnl\|CDD\|238426	cd00830, KAS_III, Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.	2.14945e-62
NZ_KE159711.1\|WP_016323966.1\|66983_68501_-\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|341253	cd05930, A_NRPS, The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.	3.50706e-131
NZ_KE159711.1\|WP_016323944.1\|40978_41599_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	8.03636e-36
NZ_KE159711.1\|WP_016323951.1\|52601_53453_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|187820	cd09689, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csd2 family.	4.35508e-112
NZ_KE159711.1\|WP_016323948.1\|47706_50082_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.8591e-55
NZ_KE159711.1\|WP_016323952.1\|53442_54105_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	5.58556e-32
NZ_KE159711.1\|WP_016323965.1\|66001_66969_-\|hypothetical-protein	gnl\|CDD\|187712	cd08369, FMT_core, Formyltransferase, catalytic core domain. Formyltransferase, catalytic core domain. The proteins of this superfamily contain a formyltransferase domain that hydrolyzes the removal of a formyl group from its substrate as part of a multistep transfer mechanism, and this alignment model represents the catalytic core of the formyltransferase domain. This family includes the following known members; Glycinamide Ribonucleotide Transformylase (GART), Formyl-FH4 Hydrolase, Methionyl-tRNA Formyltransferase, ArnA, and 10-Formyltetrahydrofolate Dehydrogenase (FDH). Glycinamide Ribonucleotide Transformylase (GART) catalyzes the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyl-FH4 Hydrolase catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to FH4 and formate. Methionyl-tRNA Formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA, which plays important role in translation initiation. ArnA is required for the modification of lipid A with 4-amino-4-deoxy-l-arabinose (Ara4N) that leads to resistance to cationic antimicrobial peptides (CAMPs) and clinical antimicrobials such as polymyxin. 10-formyltetrahydrofolate dehydrogenase (FDH) catalyzes the conversion of 10-formyltetrahydrofolate, a precursor for nucleotide biosynthesis, to tetrahydrofolate. Members of this family are multidomain proteins. The formyltransferase domain is located at the N-terminus of FDH, Methionyl-tRNA Formyltransferase and ArnA, and at the C-terminus of Formyl-FH4 Hydrolase. Prokaryotic Glycinamide Ribonucleotide Transformylase (GART) is a single domain protein while eukaryotic GART is a trifunctional protein that catalyzes the second, third and fifth steps in de novo purine biosynthesis.	1.01573e-32
NZ_KE159711.1\|WP_016323963.1\|64857_65091_-\|acyl-carrier-protein	gnl\|CDD\|223314	COG0236, AcpP, Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	0.000714317
NZ_KE159711.1\|WP_016323953.1\|54101_55133_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NZ_KE159711.1\|WP_016323958.1\|60823_61042_-\|acyl-carrier-protein	gnl\|CDD\|223314	COG0236, AcpP, Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	2.91956e-06
NZ_KE159711.1\|WP_081646417.1\|61158_61968_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.23549e-59
NZ_KE159711.1\|WP_016323961.1\|63132_63807_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	2.68952e-28
NZ_KE159711.1\|WP_016323946.1\|42781_46288_-\|S-layer-homology-domain-containing-protein	gnl\|CDD\|306825	pfam00395, SLH, S-layer homology domain.	0.000346276
NZ_KE159711.1\|WP_016323950.1\|50812_52585_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	2.21199e-142
NZ_KE159711.1\|WP_016323954.1\|55137_55428_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.9493e-29
NZ_KE159711.1\|WP_016323957.1\|59174_60710_-\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NZ_KE159711.1\|WP_016323949.1\|50084_50813_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	7.01622e-92
NZ_KE159711.1\|WP_051147130.1\|46865_47285_+\|small-multi-drug-export-protein	gnl\|CDD\|377692	pfam06695, Sm_multidrug_ex, Putative small multi-drug export protein. This family contains a small number of putative small multi-drug export proteins.	4.78608e-46
NZ_KE159711.1\|WP_016323962.1\|63781_64861_-\|hypothetical-protein	gnl\|CDD\|238426	cd00830, KAS_III, Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.	3.99312e-63

>NZ_KE159711.1|WP_016323954.1|55137_55428_+|CRISPR-associated-endonuclease-Cas2
MLVLITYDVNTEDTAGRKRLRQIAKQCVNYGQRVQNSVFECLLDTAQCRILQAKLCKIMDSEKDSLRFYYLGNRYENKIEHFGAKASYGPEDVLML
>NZ_KE159711.1|WP_016323953.1|54101_55133_+|type-I-C-CRISPR-associated-endonuclease-Cas1
MKHLLNTLYILSEDIYLSLDGENVVANRDKQTAARYPLHTLQNIITFSYSGASPALMGACAERQIGFAFCTPRGKFLARVCGEGNGNVLLRRSQYRAADDAVQCCQISRTMILGKLFNARWSIERTRRDHGLRVDSEKLTAASRQIHGLLAQVKETTDLEELRGLEGVGASAYFGVLDEMILGDKEAFFFRGRSRRPPLDAVNAMLSFAYSLLAHDCASALESVGLDSYVGFLHRDRPGRTSLALDLMEELRPCMADRFVLTLINNRQVKASDFIYMESGAVLLTDEGRRAFLKGWQEKKKETLTHPYLGEKLSWGMIPYVQALLLARCLRGDLDAYPPFLWK
>NZ_KE159711.1|WP_016323952.1|53442_54105_+|CRISPR-associated-protein-Cas4
MGFNEEDWLQLSGLQHFAFCRRQWALIHIETQWAENFRTADGHLMHEHVHDQEFRESRGDRLTVRGLAIHSAELGISGQCDAVEFHRDPAGVPLQDREGLWRPYPVEYKRGKPKEHSADELQLCAQAMCLEEMLCCTIPEGALYYGEPRRRTTVRFTPELRKQVHDSLTEMHELYKRHYTPKVKPSKACNACSLKDLCLPKLMSRKKVADYLSTAMEELE
>NZ_KE159711.1|WP_016323951.1|52601_53453_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MGILQNKIDFVAFVTVTMANPNGDPLNGNSPRTDYSGLGEMSDVCIKRKLRNRMQDLGQAVFVQSADRCDDGYGSLSERASAVLGKAKDFKDSESYAQKACETWLDVRSFGQVFAFKDTKGVSIGVRGPVSIHQGVSVSPVQVEDMQITKSVNGESGDKGRSSDTMGMKHFVRFGLYKIKGSINVQLAEKTGFTEEDSEVLKECLRTLFVNDASSARPDGSMEVAKLYWFRHNCKVGQYSSAKVHRSVHAELKDPSQLPSCAEDYQIIAEPLDGLAPEIFNGI
>NZ_KE159711.1|WP_016323950.1|50812_52585_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MGLLQKACETYDVMAYRAGIVYDGENVPLAPVSHIMARAQIEITLDQDGRFVSARTTAKEEPKIIIPVTEESAGRTSAPCAHPLCDQLGYVSPYDAKKHALYVDALSDWTSSEHSHPKLQPILTYVCGGTILSDLSGSGTLSLTAEGGPKDEKWMVCWIVNGLGEEWSGPCWTDQTLMKAFISYSRAKRTDTRSALCMVSGTVEPPAGQHPKGIIPINGNAKLISANDSSGFTFRGRFDQDWQAATVSYTASQKAHSALRWLVANQSVPFGGRTFLCWNPKGVQVPKVTGPMGRRSGGTQRAANPTQYRQQLKESLSGWKADLPQSAEVVITAFDAATTGRLAVTYYNELLASDFLDRLHDWEASCCWENGPYGIQSPSLFQIVSQAFGTPRNGKAELDDRILAQQMQRLVACRVDKTRFPLDIERALVEKASHLLLYEGENRQKLLFTACAAIRKYHYDHLKEEWDMALDKNCSDRSYLFGRLLAIADAVENSTYTSEDRRETNALRMQKAFSLRPMATWRLLEEKLVPYYKQLSPGLCQYYRKLVQEITDKLSVSDRDLNQKLDDIYLLGYYHQRAYRTEKDGKPAEA
>NZ_KE159711.1|WP_016323949.1|50084_50813_+|type-I-C-CRISPR-associated-protein-Cas5
MQYPNIVEFQVTGDYALFSDPIMRVGGEKCSYQVPTYEALKGILSSVYWKPTLIWYIDAVRMMNQIQTEVKGIRPIHYQDSKNDLSYYTYLKNCRYQVRAHFEWNENRPELAQDRNENKHHNIARRMIKTGGRRDIFLGARECQGYVEPCVFGEGPGAYDKLPELSFGLMYHGITYADEAYSPETKGKMTARFWYPTMKQGVITFPRPEDCPLTKPLREMEIKLFGEDFGNFSGLREFGEVT
>NZ_KE159711.1|WP_016323948.1|47706_50082_+|CRISPR-associated-helicase/endonuclease-Cas3
MENYLAHIRRDRQPMEVQTVSEHCRSTAKYAAQALEAVSLSSCGHLAGLLHDMGKYTASFQNYLVNQIGQRGSVNHTFAGVHLLLERFFSEDAEDFSSVASEVLALAVGGHHGLFDCIDDRQKSGFQHRLVKEGTGYEEAVENFFRFCISQEELDQRFQAAQQELTPVLERILAMTSEDNTYFDDETSFYSGLLARLLLSAVIEGDRRDTAIFMTGSEFPPARNKEDLEQLWSALLSRTEEKLEALPRETPIGQARQTISDRCKQAAEQPGGVFRLNVPTGGGKTLSSLRFALAHAHRHRKQRMIFTSPLLSILDQNAKEIRTYIQDDSLILEHHSNLLQTEEDGQQLDERELLTETWESPIIITTLVQLLNTLFSGKTAAIRRFHSLCDSIIVIDEVQTVPSKMLSLFSLAVNFLAEICGATVVLCSATQPCTEQIEHPLHNPIPEIVPYEPALWEVFRRTDIRDARTMSLEQIADFALNKLEHADSLLVVCNKKRQAEQLYNLLNGQNFALFSLSASMCIAHRRDTLDKLRNALTRCAQKVVCVSTQVIEAGVDISFACVIRLAAGMDSVVQAAGRCNRSGEAGPGVLAPVYLVRCQNESLAQLPDIRKGQGATQELLSEFAAHPELYHNSLDSAEAIQYYYRALYRREDKGHHDYCIKDRPSLLSLLSRNESCTADPPYYFRQAFRTAGSLFQVFEENTTDVIVPYGEGAALIQNLNSERAEHDPIYLKTLLEQAKPYTVSLYQYQIDRLTAEHSLIPLQGGALGLNGHYLAETGFSMDESNLDFLGV
>NZ_KE159711.1|WP_051147130.1|46865_47285_+|small-multi-drug-export-protein
MVPVVELRGAIPFGVAAGLHPLAAMGAAILGNLFPVPLILLLLRHVFRWLRHFPRLSTLIDQLERRAHLKGRKVRKYRTLGLVLLVAVPLPGTGAWTGALVADVLDIRMRTALPAVTLGVVIAGVMVTAMTCGVAGMIG
>NZ_KE159711.1|WP_016323946.1|42781_46288_-|S-layer-homology-domain-containing-protein
MKKFLSMVMALVMVMSLVTISAGAKDFTDNDVITYDEAVAVVSEVGIVDGYADGEFKPANTLTRQAAAKIICNLILGPTTAAELHADTAPYRDVPANGEFAGYIAYCQSKGIISGYADGAFRPGNTLTGYAFMKMLLGALGYDATLESYVGSNWSINVAKQAIGIGLNKGLEGEFNGIKAVTREEACLYAFNTLQADLVEYSQRLTTTINGTEVTLSSGGAHAKEWSTQQTRVNNIREDDIIQFAEEYFNKLEKKADTDEFMRPSYTWLYDKEEIGTYVNWELLVEEYTSGVTGRDLYDLLGATTLRDSDMTYYVDGLEPDEFTSVNNFAITGIGDCEQSDIVRSNTDDFGVSANGVLTQVFLEKGIGRDERNELTIVSIDTWLGRATGDYQENKEYAPIDVYYGWTPSTKTTVKAGWNVDVEDVPSVVDVQDEDYFLVNISFKENNKGDVVSLTDPEVLDKTTITKFSKSDKKVIDKLTTNGTEYKSARMAFYSDDALDEYNATLLPDHTYNVFMDPYGYVIAVELDDGAKNYVFITGFDRPTSNLSISTANAAAIFLDGTMDTIKVNVTETNKNIDRIKASETGREYFIKWTNTNFPGDEGSYRLNRWFTYSTNKSGVYTLTPAVRMTATKYGVADATDGKVTIKTANVSLKDNVLVSTNYPYSATAGTVGGWDASLATCGHPNPDSHAPFCKTYVDNNNVRAYGNDDSVFITVGLDDVDTDDGTRAITEVNDVFSGVQDVELEIDVTSAIEEAQIYTVYDRNGYIIGAVTTGEAKGGNATIAYVLSDVKSERYDSAEDAHYWEFDAFVNGEKKTLTVKDKYGTLQGAVDTEYAKNTHSSGIGTNGVTDYNRYDGIVELRFDADENVVDIKNVVEKDIYNYYLGGKSIQDNTATGIDGYTKMNLDDAKVYRMNVLNSTYTKGLTWAFGGVTHNYDSAPDTVMLRGRTMYVTADRHDEGLALTSDAKALVIQKENGSWEKTEYNTVASAISGLADADETTDGLQYNGEIVAAINGSGAATWVVFINYTELVTGSRPVPGSGRLTAIDVAGDGFWNDDTPARDYGDTYRHLGYSNPGYDYSARYYAAAPTGTYGTGKLTYQLVGSASGQTYKMVLEVLGANGWIVYDEWNVKATTANYTDRHYVGVLNPASQWRLTCGNVVAAVSIVH
>NZ_KE159711.1|WP_016323944.1|40978_41599_-|recombinase-family-protein
MGENTYGYIRVSSTDQNEDRQRIALRKRAVPKENIYMDKQSGKDFNRPQYKKLVRRLRTGDLLYVLSIDRLGRDYEEIQNQWRVLTKEIGVDICVIDMPLLDTRSGKDLMGTFIADLVLQILSFVAESERTNIRQRQAEGIEAARARGVRFGRPPRALPENYHSVYQRWRTGDITGVAAARECGMPLSTFRYRARIYESAKRQDHT
>NZ_KE159711.1|WP_016323957.1|59174_60710_-|acyl-CoA-carboxylase-subunit-beta
MWDKAVFEELERRETASRAGGGAARMAKQHAAGKLTARERMDILFDPGTFTEIGGLIESRPLDFGTEQERIPGDGVITGYGKIHGRLAFAAFEDFTVFGGTLGESHALKICKLQDMALEMRAPLITVNDSGGARIGEGLHSLNGYSGIFLRNTEASGVIPQIAVIMGPCAGGACYSPAICDFIFMVERSSYMFITGPQVMKTVTSETVTVEELGGARVHATESGVSHFTYPDDKSCLEGVRRLLTYLPQNNRENPPGIAGAVPGDCAGLQELVPQNPRKAYDIHKVIDAVLDRDSFFEVQAEWARNAVVGFGRLGGGTVGIVANQPAYMGGSLDYHVSDKMARFIRTCDCFNVPLLILIDVPAFLPGKEQEHNGIIRHGAKLLYAFSEASVPKISVVLRKAYGGAYIAMNSKRMGADMVFAWPIAELAVMGAEGAVEILFRKELRAAPKRRDELVEEYETLFMNPYIAAARGFIDEVIRPEDTRKRILAALEMLEKKERTTPWKKHGNIPL
>NZ_KE159711.1|WP_016323958.1|60823_61042_-|acyl-carrier-protein
MELTKKLALLEETLDTDEGALNPETVLDDMESWDSLAMLSLIAMLDEEFGKTISGKELKSLKTVADILGYME
>NZ_KE159711.1|WP_081646417.1|61158_61968_-|SDR-family-oxidoreductase
MTALTASLILLRREERTDMIQQEFDGRKIIVFGASSGIGRACAIQLGEQSANVILVGRNMERLEETAGHIPEGRRTILPCDVSDFDAARAVVEDAVELDGAKLDGCVFSAGVSTLGPITAIREPLLLEIFRTNLFSLYGILKVFSSRRISRDGASFVSISSMAAFMPTKGQSIYAGTKGAINSITIGVAKELAKRRIRVNTICPAMADTPMGAAYLERMEEGRYPLGKLMPEDIADAVLFLLSNASKKITGQAIQITAGDIGGNDNFVF
>NZ_KE159711.1|WP_040656198.1|61915_63127_-|hypothetical-protein
MGSICALTREGRGGGRQTLEAPGANLKKGVMSMYFNEFSNVRISALAAAVPDHREQLINYAAQFSTEEIEKFCKSTGIQERYSSVGVGTTAADLCVAAAEEIFQRTGIKRDSIDGLILLTQTPDYMTPPTSCIIQYRLGLDNCGLVYDSSIGCSGFPFGIQMACADLMAGCEKILLLVGDSFVECPGMQKDDLLFGDCGVAVVLEKVSETVAPIKVGIRTIGKGYPSLISPYGMQRHPLSDFYRDRGLEDALAYNNKGTMHGTDVFTFSIKDAPKATKEFLAHFDCQMDDYDLISIHQANKMIVDNVAKRVQAPAEKVLWSLNRYGNTRGSSTAMNICDYVQRENLHKGMKRILNLAFGVGLNVALAGFELDLSVVLPVVKTSAVFDDGIDSFSYFTKEGGED
>NZ_KE159711.1|WP_016323961.1|63132_63807_-|MBL-fold-metallo-hydrolase
MKCLHPIFDRPVYRFAMPVIDSSMYLVPADGSCLVVDPCISEEAEKLLRELRIESCLVLLTHEHYDHISGVNWLRERLPCQVVCSESCAGRIADPKKNLAAYFKAIALQKDKSEKAALEGFLEPRYACRADRTYTGRLEICWENLTLNLREAPGHSPGSQLIEVGKHWYFTGDSLIPETPLVTQLPGGSRKLYEEKTRPCLEAISPGSILFPGHGGESVFSGEL
>NZ_KE159711.1|WP_016323962.1|63781_64861_-|hypothetical-protein
MKTVFRGKRITGLLSVLPAASVAFEDEVGNYTFPAKQTLRLQKVMGFKRHSIVKETTAASDLAAAGLACLFEKGWLRREEIGALVVSCSYTDHFIPPVSSILHGKFDLPEDVLCADISQGCGGFLMALTESFLLLDHLEPGKKTVAIATDVLSKRVSRQDRNSWPLIGDAAGIAVVENDPEADGIPTVIYNNGGLGQALMIPAGGSRMPSTPETARSEDRDGDGNLRALDNLTMQGADVFNFMQTKVPPLIEETLAYAGLTKEQIDWYLFHQPNRFMLRKLAEKLGVPYEKMPMNVVEELGNSSGACIPVCAVHNLAEELRAPEERTCCLAAFGSGLMWGAMIVKLGGMRFCEMLTSDL
>NZ_KE159711.1|WP_016323963.1|64857_65091_-|acyl-carrier-protein
MKTILQILSGLRPEFDFSSSRDFIDDGYLDSFDIVALISELEETFHILIDGMDVLPENFCSVEAIAATVRKNGGTLD
>NZ_KE159711.1|WP_155979098.1|65101_65821_-|GNAT-family-N-acetyltransferase
MLTVLTELSEREDTRLIYNEHAIALIYDDNGVTRLYLDLSSLEAAPALRELLGQICARPIIIDCVGSAERVEEVSLALCTAGFAPYAHLRRLRNTNIQYHPEADAVIQPALPEDCEPIFSLLCETFDPYVSHLPSREKLLRLINDQLVYRIVENGEIAAVQCLERTGTRGLYIYQTLVAPPYRGRGLGTLVIPYIPGCCAGSCSFFTVWVIDGNERSVRVLQRSGAVFDGLEDTVLIFR
>NZ_KE159711.1|WP_016323965.1|66001_66969_-|hypothetical-protein
MSINLRKANSLAVFGSGTIAARCVKLLRDMVDAEIYVYEKKQSNVSILERSLSHIAGVHYGEVGEGLEAEILEVNPAVIFSINNVYLFPGSLAERVPILNYHNSLLPKHPGRNAEAWTIFSQDQTAGVTWHFVDAHVDTGNIVAQREILLSPHITSIRLLSLQTQTAFNMFQEILNDLCRGEELPRRKQEERKDIKFHFSWERPNDGMLSLAWDISQTYAFLRAMDYGKLALLGVPLLEYDGIRYSWERYALEPSPGDAAFSLDLLHDTCTISRDGESVRLFGLKQDTSQKCDQEKGEESAMFDMQELLARKEGRKEGRKEG
>NZ_KE159711.1|WP_016323966.1|66983_68501_-|amino-acid-adenylation-domain-containing-protein
MIKNILEYFERTLAEAPEKTAVIDGEREITFAELSGNALALAAQLRRKSHGQIRQPVAVYLPKSIESITSDLGIVYSGNAYMNLDVKTPGRRIANILDLVDPLFVITDGKHQAALSAVWPEDRTVLVDGQIPRAGAEEELQRALEDVIDTDPLCLINTSGSTGTPKSVVLNHRSFIDYTTWAIETLGLRQDDIAGSIAPIVFDHFSYEFCLMLVRGCTLLLIPENYPSFPARLLQFLQERHATYLFWVPTIMVNIANMDLLSRIPLPEVRMVWFAGEVFPTKQFNYWRRQLPQATFVNLYGPTEITVDCTYYVADRPLRDDEPIPIGKPCRNTDILILNGENRLVSPGEEGELCVRGSSLAMGYYNNPEKTAAVFVQNPLNTAYPELIYRTGDIVYINEEGEIVYKGRNDSLIKHMGKRVELGEIEHVIVNTLQLVRNGCAVYDHGKKEIVFFYEAPKELEAAVLRREIGRQLPQYMVPGRFIHMELLPRNTNGKIDRLRLREGI

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Crispr_ID: NZ_KE159711_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159711_2

57612-58986

TypeI

I-C

Consensus_repeat	Method
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	PILER-CR
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CRISPRCasFinder
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAATGNN	CRT

20 spacers

cas2,cas1,cas4,cas7,cas8c,cas5,cas3

The CRISPR arrays of NZ_KE159711_2

>merge|NZ_KE159711|2|57612-58986|PILER-CR,CRISPRCasFinder,CRT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAATAGTGCGAACGAAATCGTTGGATTGGGCTTTTGAGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATGTGAAGGTTTTCCGCGCCGGAGGCTCCGGCCTCGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATTCATCGATACAAAAGAAAACGAGGGTTTCCGGGTGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATGTGAAATTGGCGCAATCATGATGAATTACACGCCGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATCTCTTGAACCATTCTTTCTTTTTTAATATTGGCAGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATAACTGTTGCGGATATACGTTAATCACCTGCAGGAGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATTGTCCCGCAGGGCTGGCGGGTGCTCCGTGTACTTTGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATAATTCCAAGTCCCGGAATAGTTCGGTCAGCTCCTCGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATAATTCTCCAGCTTCTCCGCGTCCAGCCTGATGAAGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATTCGCCTGGTGACGGACCGGACCCAGGCGGACGTGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATCTCTTTGTTATGGTCCTATTATACACGCAATGCGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATAATGATGGCGGCGCGGTCCTTGGTCTCGCCCGTCAGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATCCAGGCTTCCGGCTGTCATAGTAGTACTCCCGCGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATCAGGATGTGCTGCTGTGTGACGGACACGGAGCCGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATATCAGCCTGTCCTGGCCGTTTAGAGCTTGGGACAGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATATCGGGAACAGGCTGCTGGCATGGCTGCTAACCAGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATACCTCCACATCGACCGCGCTGATGATAACCGTGAGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATTCGGACTGCTGCGCCTCATAGATCCGGCTGGCCTGGTCGCCCCCCATGCGGGGGGCGTGGATTGAAATTCATAGGTGGCGTTCCGGGACAGGGAGGCGATGAGTCGCCCCCCATGCGGGGGCGTGGATTGAAATGCCTGATAGGCAGGGTCTTCCAAAGCCTCCCGCAGTCGCCCCCATGCGGGGCATAGATTGAATTGAC

>NZ_KE159711|2|2|57612-58919|PILER-CR
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AGTGCGAACGAAATCGTTGGATTGGGCTTTTGA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GTGAAGGTTTTCCGCGCCGGAGGCTCCGGCCTC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCATCGATACAAAAGAAAACGAGGGTTTCCGGGTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GTGAAATTGGCGCAATCATGATGAATTACACGCC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTCTTGAACCATTCTTTCTTTTTTAATATTGGCA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AACTGTTGCGGATATACGTTAATCACCTGCAGGA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TGTCCCGCAGGGCTGGCGGGTGCTCCGTGTACTTT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AATTCCAAGTCCCGGAATAGTTCGGTCAGCTCCTC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AATTCTCCAGCTTCTCCGCGTCCAGCCTGATGAA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCGCCTGGTGACGGACCGGACCCAGGCGGACGTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTCTTTGTTATGGTCCTATTATACACGCAATGCG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AATGATGGCGGCGCGGTCCTTGGTCTCGCCCGTCA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCAGGCTTCCGGCTGTCATAGTAGTACTCCCGC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CAGGATGTGCTGCTGTGTGACGGACACGGAGCCG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATCAGCCTGTCCTGGCCGTTTAGAGCTTGGGACA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATCGGGAACAGGCTGCTGGCATGGCTGCTAACCA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ACCTCCACATCGACCGCGCTGATGATAACCGTGAG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCGGACTGCTGCGCCTCATAGATCCGGCTGGCCTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCATAGGTGGCGTTCCGGGACAGGGAGGCGATGA
GTCGCCCCCCATGCGGGGGCGTGGATTGAAAT

>NZ_KE159711|2|2|57612-58919|CRISPRCasFinder
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AGTGCGAACGAAATCGTTGGATTGGGCTTTTGA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GTGAAGGTTTTCCGCGCCGGAGGCTCCGGCCTC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCATCGATACAAAAGAAAACGAGGGTTTCCGGGTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GTGAAATTGGCGCAATCATGATGAATTACACGCC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTCTTGAACCATTCTTTCTTTTTTAATATTGGCA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AACTGTTGCGGATATACGTTAATCACCTGCAGGA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TGTCCCGCAGGGCTGGCGGGTGCTCCGTGTACTTT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AATTCCAAGTCCCGGAATAGTTCGGTCAGCTCCTC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AATTCTCCAGCTTCTCCGCGTCCAGCCTGATGAA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCGCCTGGTGACGGACCGGACCCAGGCGGACGTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTCTTTGTTATGGTCCTATTATACACGCAATGCG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AATGATGGCGGCGCGGTCCTTGGTCTCGCCCGTCA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCAGGCTTCCGGCTGTCATAGTAGTACTCCCGC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CAGGATGTGCTGCTGTGTGACGGACACGGAGCCG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATCAGCCTGTCCTGGCCGTTTAGAGCTTGGGACA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATCGGGAACAGGCTGCTGGCATGGCTGCTAACCA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ACCTCCACATCGACCGCGCTGATGATAACCGTGAG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCGGACTGCTGCGCCTCATAGATCCGGCTGGCCTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCATAGGTGGCGTTCCGGGACAGGGAGGCGATG
AGTCGCCCCCCATGCGGGGGCGTGGATTGAAAT

>NZ_KE159711|2|2|57612-58986|CRT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AGTGCGAACGAAATCGTTGGATTGGGCTTTTGA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GTGAAGGTTTTCCGCGCCGGAGGCTCCGGCCTC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCATCGATACAAAAGAAAACGAGGGTTTCCGGGTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	GTGAAATTGGCGCAATCATGATGAATTACACGCC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTCTTGAACCATTCTTTCTTTTTTAATATTGGCA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AACTGTTGCGGATATACGTTAATCACCTGCAGGA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TGTCCCGCAGGGCTGGCGGGTGCTCCGTGTACTTT
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AATTCCAAGTCCCGGAATAGTTCGGTCAGCTCCTC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AATTCTCCAGCTTCTCCGCGTCCAGCCTGATGAA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCGCCTGGTGACGGACCGGACCCAGGCGGACGTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CTCTTTGTTATGGTCCTATTATACACGCAATGCG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	AATGATGGCGGCGCGGTCCTTGGTCTCGCCCGTCA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CCAGGCTTCCGGCTGTCATAGTAGTACTCCCGC
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	CAGGATGTGCTGCTGTGTGACGGACACGGAGCCG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATCAGCCTGTCCTGGCCGTTTAGAGCTTGGGACA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ATCGGGAACAGGCTGCTGGCATGGCTGCTAACCA
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	ACCTCCACATCGACCGCGCTGATGATAACCGTGAG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCGGACTGCTGCGCCTCATAGATCCGGCTGGCCTG
GTCGCCCCCCATGCGGGGGGCGTGGATTGAAAT	TCATAGGTGGCGTTCCGGGACAGGGAGGCGATGA
GTCGCCCCCCATGCGGGGGCGTGGATTGAAATG	CCTGATAGGCAGGGTCTTCCAAAGCCTCCCGCA
GTCGCCCCCATGCGGGGCATAGATTGAATTGAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159711.1\|WP_155979098.1\|65101_65821_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NZ_KE159711.1\|WP_040656198.1\|61915_63127_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238426
NZ_KE159711.1\|WP_016323966.1\|66983_68501_-\|amino-acid-adenylation-domain-containing-protein	unknown	unknown	gnl\|CDD\|341253
NZ_KE159711.1\|WP_016323944.1\|40978_41599_-\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_KE159711.1\|WP_016323951.1\|52601_53453_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7	COG3649_cas7_CAS-I-C	gnl\|CDD\|187820
NZ_KE159711.1\|WP_016323948.1\|47706_50082_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
NZ_KE159711.1\|WP_016323952.1\|53442_54105_+\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|273040
NZ_KE159711.1\|WP_016323965.1\|66001_66969_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|187712
NZ_KE159711.1\|WP_016323963.1\|64857_65091_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|223314
NZ_KE159711.1\|WP_016323953.1\|54101_55133_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	cas1	cd09721_cas1_CAS-I-C	gnl\|CDD\|188360
NZ_KE159711.1\|WP_016323958.1\|60823_61042_-\|acyl-carrier-protein	unknown	unknown	gnl\|CDD\|223314
NZ_KE159711.1\|WP_081646417.1\|61158_61968_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|212491
NZ_KE159711.1\|WP_016323961.1\|63132_63807_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
NZ_KE159711.1\|WP_016323946.1\|42781_46288_-\|S-layer-homology-domain-containing-protein	unknown	unknown	gnl\|CDD\|306825
NZ_KE159711.1\|WP_016323950.1\|50812_52585_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	pfam09709_cas8c_CAS-I-C	gnl\|CDD\|378245
NZ_KE159711.1\|WP_016323954.1\|55137_55428_+\|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
NZ_KE159711.1\|WP_016323957.1\|59174_60710_-\|acyl-CoA-carboxylase-subunit-beta	unknown	unknown	gnl\|CDD\|227136
NZ_KE159711.1\|WP_016323949.1\|50084_50813_+\|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09752_cas5_CAS-I-C	gnl\|CDD\|187534
NZ_KE159711.1\|WP_051147130.1\|46865_47285_+\|small-multi-drug-export-protein	unknown	unknown	gnl\|CDD\|377692
NZ_KE159711.1\|WP_016323962.1\|63781_64861_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238426

Protein	Function_ID	Function_description	E-value
NZ_KE159711.1\|WP_155979098.1\|65101_65821_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	0.000609084
NZ_KE159711.1\|WP_040656198.1\|61915_63127_-\|hypothetical-protein	gnl\|CDD\|238426	cd00830, KAS_III, Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.	2.14945e-62
NZ_KE159711.1\|WP_016323966.1\|66983_68501_-\|amino-acid-adenylation-domain-containing-protein	gnl\|CDD\|341253	cd05930, A_NRPS, The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.	3.50706e-131
NZ_KE159711.1\|WP_016323944.1\|40978_41599_-\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	8.03636e-36
NZ_KE159711.1\|WP_016323951.1\|52601_53453_+\|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl\|CDD\|187820	cd09689, Cas7_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas7. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas7 is a RAMP superfamily protein; Subunit of the Cascade complex; also known as Csd2 family.	4.35508e-112
NZ_KE159711.1\|WP_016323948.1\|47706_50082_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	1.8591e-55
NZ_KE159711.1\|WP_016323952.1\|53442_54105_+\|CRISPR-associated-protein-Cas4	gnl\|CDD\|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	5.58556e-32
NZ_KE159711.1\|WP_016323965.1\|66001_66969_-\|hypothetical-protein	gnl\|CDD\|187712	cd08369, FMT_core, Formyltransferase, catalytic core domain. Formyltransferase, catalytic core domain. The proteins of this superfamily contain a formyltransferase domain that hydrolyzes the removal of a formyl group from its substrate as part of a multistep transfer mechanism, and this alignment model represents the catalytic core of the formyltransferase domain. This family includes the following known members; Glycinamide Ribonucleotide Transformylase (GART), Formyl-FH4 Hydrolase, Methionyl-tRNA Formyltransferase, ArnA, and 10-Formyltetrahydrofolate Dehydrogenase (FDH). Glycinamide Ribonucleotide Transformylase (GART) catalyzes the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyl-FH4 Hydrolase catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to FH4 and formate. Methionyl-tRNA Formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA, which plays important role in translation initiation. ArnA is required for the modification of lipid A with 4-amino-4-deoxy-l-arabinose (Ara4N) that leads to resistance to cationic antimicrobial peptides (CAMPs) and clinical antimicrobials such as polymyxin. 10-formyltetrahydrofolate dehydrogenase (FDH) catalyzes the conversion of 10-formyltetrahydrofolate, a precursor for nucleotide biosynthesis, to tetrahydrofolate. Members of this family are multidomain proteins. The formyltransferase domain is located at the N-terminus of FDH, Methionyl-tRNA Formyltransferase and ArnA, and at the C-terminus of Formyl-FH4 Hydrolase. Prokaryotic Glycinamide Ribonucleotide Transformylase (GART) is a single domain protein while eukaryotic GART is a trifunctional protein that catalyzes the second, third and fifth steps in de novo purine biosynthesis.	1.01573e-32
NZ_KE159711.1\|WP_016323963.1\|64857_65091_-\|acyl-carrier-protein	gnl\|CDD\|223314	COG0236, AcpP, Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	0.000714317
NZ_KE159711.1\|WP_016323953.1\|54101_55133_+\|type-I-C-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|188360	TIGR03640, cas1_DVULG, CRISPR-associated endonuclease Cas1, subtype I-C/DVULG. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the DVULG subtype of CRISPR/Cas system.	0
NZ_KE159711.1\|WP_016323958.1\|60823_61042_-\|acyl-carrier-protein	gnl\|CDD\|223314	COG0236, AcpP, Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	2.91956e-06
NZ_KE159711.1\|WP_081646417.1\|61158_61968_-\|SDR-family-oxidoreductase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	1.23549e-59
NZ_KE159711.1\|WP_016323961.1\|63132_63807_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	2.68952e-28
NZ_KE159711.1\|WP_016323946.1\|42781_46288_-\|S-layer-homology-domain-containing-protein	gnl\|CDD\|306825	pfam00395, SLH, S-layer homology domain.	0.000346276
NZ_KE159711.1\|WP_016323950.1\|50812_52585_+\|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl\|CDD\|378245	pfam09709, Cas_Csd1, CRISPR-associated protein (Cas_Csd1). CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	2.21199e-142
NZ_KE159711.1\|WP_016323954.1\|55137_55428_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	3.9493e-29
NZ_KE159711.1\|WP_016323957.1\|59174_60710_-\|acyl-CoA-carboxylase-subunit-beta	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	0
NZ_KE159711.1\|WP_016323949.1\|50084_50813_+\|type-I-C-CRISPR-associated-protein-Cas5	gnl\|CDD\|187534	cd09752, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	7.01622e-92
NZ_KE159711.1\|WP_051147130.1\|46865_47285_+\|small-multi-drug-export-protein	gnl\|CDD\|377692	pfam06695, Sm_multidrug_ex, Putative small multi-drug export protein. This family contains a small number of putative small multi-drug export proteins.	4.78608e-46
NZ_KE159711.1\|WP_016323962.1\|63781_64861_-\|hypothetical-protein	gnl\|CDD\|238426	cd00830, KAS_III, Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.	3.99312e-63

>NZ_KE159711.1|WP_016323954.1|55137_55428_+|CRISPR-associated-endonuclease-Cas2
MLVLITYDVNTEDTAGRKRLRQIAKQCVNYGQRVQNSVFECLLDTAQCRILQAKLCKIMDSEKDSLRFYYLGNRYENKIEHFGAKASYGPEDVLML
>NZ_KE159711.1|WP_016323953.1|54101_55133_+|type-I-C-CRISPR-associated-endonuclease-Cas1
MKHLLNTLYILSEDIYLSLDGENVVANRDKQTAARYPLHTLQNIITFSYSGASPALMGACAERQIGFAFCTPRGKFLARVCGEGNGNVLLRRSQYRAADDAVQCCQISRTMILGKLFNARWSIERTRRDHGLRVDSEKLTAASRQIHGLLAQVKETTDLEELRGLEGVGASAYFGVLDEMILGDKEAFFFRGRSRRPPLDAVNAMLSFAYSLLAHDCASALESVGLDSYVGFLHRDRPGRTSLALDLMEELRPCMADRFVLTLINNRQVKASDFIYMESGAVLLTDEGRRAFLKGWQEKKKETLTHPYLGEKLSWGMIPYVQALLLARCLRGDLDAYPPFLWK
>NZ_KE159711.1|WP_016323952.1|53442_54105_+|CRISPR-associated-protein-Cas4
MGFNEEDWLQLSGLQHFAFCRRQWALIHIETQWAENFRTADGHLMHEHVHDQEFRESRGDRLTVRGLAIHSAELGISGQCDAVEFHRDPAGVPLQDREGLWRPYPVEYKRGKPKEHSADELQLCAQAMCLEEMLCCTIPEGALYYGEPRRRTTVRFTPELRKQVHDSLTEMHELYKRHYTPKVKPSKACNACSLKDLCLPKLMSRKKVADYLSTAMEELE
>NZ_KE159711.1|WP_016323951.1|52601_53453_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MGILQNKIDFVAFVTVTMANPNGDPLNGNSPRTDYSGLGEMSDVCIKRKLRNRMQDLGQAVFVQSADRCDDGYGSLSERASAVLGKAKDFKDSESYAQKACETWLDVRSFGQVFAFKDTKGVSIGVRGPVSIHQGVSVSPVQVEDMQITKSVNGESGDKGRSSDTMGMKHFVRFGLYKIKGSINVQLAEKTGFTEEDSEVLKECLRTLFVNDASSARPDGSMEVAKLYWFRHNCKVGQYSSAKVHRSVHAELKDPSQLPSCAEDYQIIAEPLDGLAPEIFNGI
>NZ_KE159711.1|WP_016323950.1|50812_52585_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MGLLQKACETYDVMAYRAGIVYDGENVPLAPVSHIMARAQIEITLDQDGRFVSARTTAKEEPKIIIPVTEESAGRTSAPCAHPLCDQLGYVSPYDAKKHALYVDALSDWTSSEHSHPKLQPILTYVCGGTILSDLSGSGTLSLTAEGGPKDEKWMVCWIVNGLGEEWSGPCWTDQTLMKAFISYSRAKRTDTRSALCMVSGTVEPPAGQHPKGIIPINGNAKLISANDSSGFTFRGRFDQDWQAATVSYTASQKAHSALRWLVANQSVPFGGRTFLCWNPKGVQVPKVTGPMGRRSGGTQRAANPTQYRQQLKESLSGWKADLPQSAEVVITAFDAATTGRLAVTYYNELLASDFLDRLHDWEASCCWENGPYGIQSPSLFQIVSQAFGTPRNGKAELDDRILAQQMQRLVACRVDKTRFPLDIERALVEKASHLLLYEGENRQKLLFTACAAIRKYHYDHLKEEWDMALDKNCSDRSYLFGRLLAIADAVENSTYTSEDRRETNALRMQKAFSLRPMATWRLLEEKLVPYYKQLSPGLCQYYRKLVQEITDKLSVSDRDLNQKLDDIYLLGYYHQRAYRTEKDGKPAEA
>NZ_KE159711.1|WP_016323949.1|50084_50813_+|type-I-C-CRISPR-associated-protein-Cas5
MQYPNIVEFQVTGDYALFSDPIMRVGGEKCSYQVPTYEALKGILSSVYWKPTLIWYIDAVRMMNQIQTEVKGIRPIHYQDSKNDLSYYTYLKNCRYQVRAHFEWNENRPELAQDRNENKHHNIARRMIKTGGRRDIFLGARECQGYVEPCVFGEGPGAYDKLPELSFGLMYHGITYADEAYSPETKGKMTARFWYPTMKQGVITFPRPEDCPLTKPLREMEIKLFGEDFGNFSGLREFGEVT
>NZ_KE159711.1|WP_016323948.1|47706_50082_+|CRISPR-associated-helicase/endonuclease-Cas3
MENYLAHIRRDRQPMEVQTVSEHCRSTAKYAAQALEAVSLSSCGHLAGLLHDMGKYTASFQNYLVNQIGQRGSVNHTFAGVHLLLERFFSEDAEDFSSVASEVLALAVGGHHGLFDCIDDRQKSGFQHRLVKEGTGYEEAVENFFRFCISQEELDQRFQAAQQELTPVLERILAMTSEDNTYFDDETSFYSGLLARLLLSAVIEGDRRDTAIFMTGSEFPPARNKEDLEQLWSALLSRTEEKLEALPRETPIGQARQTISDRCKQAAEQPGGVFRLNVPTGGGKTLSSLRFALAHAHRHRKQRMIFTSPLLSILDQNAKEIRTYIQDDSLILEHHSNLLQTEEDGQQLDERELLTETWESPIIITTLVQLLNTLFSGKTAAIRRFHSLCDSIIVIDEVQTVPSKMLSLFSLAVNFLAEICGATVVLCSATQPCTEQIEHPLHNPIPEIVPYEPALWEVFRRTDIRDARTMSLEQIADFALNKLEHADSLLVVCNKKRQAEQLYNLLNGQNFALFSLSASMCIAHRRDTLDKLRNALTRCAQKVVCVSTQVIEAGVDISFACVIRLAAGMDSVVQAAGRCNRSGEAGPGVLAPVYLVRCQNESLAQLPDIRKGQGATQELLSEFAAHPELYHNSLDSAEAIQYYYRALYRREDKGHHDYCIKDRPSLLSLLSRNESCTADPPYYFRQAFRTAGSLFQVFEENTTDVIVPYGEGAALIQNLNSERAEHDPIYLKTLLEQAKPYTVSLYQYQIDRLTAEHSLIPLQGGALGLNGHYLAETGFSMDESNLDFLGV
>NZ_KE159711.1|WP_051147130.1|46865_47285_+|small-multi-drug-export-protein
MVPVVELRGAIPFGVAAGLHPLAAMGAAILGNLFPVPLILLLLRHVFRWLRHFPRLSTLIDQLERRAHLKGRKVRKYRTLGLVLLVAVPLPGTGAWTGALVADVLDIRMRTALPAVTLGVVIAGVMVTAMTCGVAGMIG
>NZ_KE159711.1|WP_016323946.1|42781_46288_-|S-layer-homology-domain-containing-protein
MKKFLSMVMALVMVMSLVTISAGAKDFTDNDVITYDEAVAVVSEVGIVDGYADGEFKPANTLTRQAAAKIICNLILGPTTAAELHADTAPYRDVPANGEFAGYIAYCQSKGIISGYADGAFRPGNTLTGYAFMKMLLGALGYDATLESYVGSNWSINVAKQAIGIGLNKGLEGEFNGIKAVTREEACLYAFNTLQADLVEYSQRLTTTINGTEVTLSSGGAHAKEWSTQQTRVNNIREDDIIQFAEEYFNKLEKKADTDEFMRPSYTWLYDKEEIGTYVNWELLVEEYTSGVTGRDLYDLLGATTLRDSDMTYYVDGLEPDEFTSVNNFAITGIGDCEQSDIVRSNTDDFGVSANGVLTQVFLEKGIGRDERNELTIVSIDTWLGRATGDYQENKEYAPIDVYYGWTPSTKTTVKAGWNVDVEDVPSVVDVQDEDYFLVNISFKENNKGDVVSLTDPEVLDKTTITKFSKSDKKVIDKLTTNGTEYKSARMAFYSDDALDEYNATLLPDHTYNVFMDPYGYVIAVELDDGAKNYVFITGFDRPTSNLSISTANAAAIFLDGTMDTIKVNVTETNKNIDRIKASETGREYFIKWTNTNFPGDEGSYRLNRWFTYSTNKSGVYTLTPAVRMTATKYGVADATDGKVTIKTANVSLKDNVLVSTNYPYSATAGTVGGWDASLATCGHPNPDSHAPFCKTYVDNNNVRAYGNDDSVFITVGLDDVDTDDGTRAITEVNDVFSGVQDVELEIDVTSAIEEAQIYTVYDRNGYIIGAVTTGEAKGGNATIAYVLSDVKSERYDSAEDAHYWEFDAFVNGEKKTLTVKDKYGTLQGAVDTEYAKNTHSSGIGTNGVTDYNRYDGIVELRFDADENVVDIKNVVEKDIYNYYLGGKSIQDNTATGIDGYTKMNLDDAKVYRMNVLNSTYTKGLTWAFGGVTHNYDSAPDTVMLRGRTMYVTADRHDEGLALTSDAKALVIQKENGSWEKTEYNTVASAISGLADADETTDGLQYNGEIVAAINGSGAATWVVFINYTELVTGSRPVPGSGRLTAIDVAGDGFWNDDTPARDYGDTYRHLGYSNPGYDYSARYYAAAPTGTYGTGKLTYQLVGSASGQTYKMVLEVLGANGWIVYDEWNVKATTANYTDRHYVGVLNPASQWRLTCGNVVAAVSIVH
>NZ_KE159711.1|WP_016323944.1|40978_41599_-|recombinase-family-protein
MGENTYGYIRVSSTDQNEDRQRIALRKRAVPKENIYMDKQSGKDFNRPQYKKLVRRLRTGDLLYVLSIDRLGRDYEEIQNQWRVLTKEIGVDICVIDMPLLDTRSGKDLMGTFIADLVLQILSFVAESERTNIRQRQAEGIEAARARGVRFGRPPRALPENYHSVYQRWRTGDITGVAAARECGMPLSTFRYRARIYESAKRQDHT
>NZ_KE159711.1|WP_016323957.1|59174_60710_-|acyl-CoA-carboxylase-subunit-beta
MWDKAVFEELERRETASRAGGGAARMAKQHAAGKLTARERMDILFDPGTFTEIGGLIESRPLDFGTEQERIPGDGVITGYGKIHGRLAFAAFEDFTVFGGTLGESHALKICKLQDMALEMRAPLITVNDSGGARIGEGLHSLNGYSGIFLRNTEASGVIPQIAVIMGPCAGGACYSPAICDFIFMVERSSYMFITGPQVMKTVTSETVTVEELGGARVHATESGVSHFTYPDDKSCLEGVRRLLTYLPQNNRENPPGIAGAVPGDCAGLQELVPQNPRKAYDIHKVIDAVLDRDSFFEVQAEWARNAVVGFGRLGGGTVGIVANQPAYMGGSLDYHVSDKMARFIRTCDCFNVPLLILIDVPAFLPGKEQEHNGIIRHGAKLLYAFSEASVPKISVVLRKAYGGAYIAMNSKRMGADMVFAWPIAELAVMGAEGAVEILFRKELRAAPKRRDELVEEYETLFMNPYIAAARGFIDEVIRPEDTRKRILAALEMLEKKERTTPWKKHGNIPL
>NZ_KE159711.1|WP_016323958.1|60823_61042_-|acyl-carrier-protein
MELTKKLALLEETLDTDEGALNPETVLDDMESWDSLAMLSLIAMLDEEFGKTISGKELKSLKTVADILGYME
>NZ_KE159711.1|WP_081646417.1|61158_61968_-|SDR-family-oxidoreductase
MTALTASLILLRREERTDMIQQEFDGRKIIVFGASSGIGRACAIQLGEQSANVILVGRNMERLEETAGHIPEGRRTILPCDVSDFDAARAVVEDAVELDGAKLDGCVFSAGVSTLGPITAIREPLLLEIFRTNLFSLYGILKVFSSRRISRDGASFVSISSMAAFMPTKGQSIYAGTKGAINSITIGVAKELAKRRIRVNTICPAMADTPMGAAYLERMEEGRYPLGKLMPEDIADAVLFLLSNASKKITGQAIQITAGDIGGNDNFVF
>NZ_KE159711.1|WP_040656198.1|61915_63127_-|hypothetical-protein
MGSICALTREGRGGGRQTLEAPGANLKKGVMSMYFNEFSNVRISALAAAVPDHREQLINYAAQFSTEEIEKFCKSTGIQERYSSVGVGTTAADLCVAAAEEIFQRTGIKRDSIDGLILLTQTPDYMTPPTSCIIQYRLGLDNCGLVYDSSIGCSGFPFGIQMACADLMAGCEKILLLVGDSFVECPGMQKDDLLFGDCGVAVVLEKVSETVAPIKVGIRTIGKGYPSLISPYGMQRHPLSDFYRDRGLEDALAYNNKGTMHGTDVFTFSIKDAPKATKEFLAHFDCQMDDYDLISIHQANKMIVDNVAKRVQAPAEKVLWSLNRYGNTRGSSTAMNICDYVQRENLHKGMKRILNLAFGVGLNVALAGFELDLSVVLPVVKTSAVFDDGIDSFSYFTKEGGED
>NZ_KE159711.1|WP_016323961.1|63132_63807_-|MBL-fold-metallo-hydrolase
MKCLHPIFDRPVYRFAMPVIDSSMYLVPADGSCLVVDPCISEEAEKLLRELRIESCLVLLTHEHYDHISGVNWLRERLPCQVVCSESCAGRIADPKKNLAAYFKAIALQKDKSEKAALEGFLEPRYACRADRTYTGRLEICWENLTLNLREAPGHSPGSQLIEVGKHWYFTGDSLIPETPLVTQLPGGSRKLYEEKTRPCLEAISPGSILFPGHGGESVFSGEL
>NZ_KE159711.1|WP_016323962.1|63781_64861_-|hypothetical-protein
MKTVFRGKRITGLLSVLPAASVAFEDEVGNYTFPAKQTLRLQKVMGFKRHSIVKETTAASDLAAAGLACLFEKGWLRREEIGALVVSCSYTDHFIPPVSSILHGKFDLPEDVLCADISQGCGGFLMALTESFLLLDHLEPGKKTVAIATDVLSKRVSRQDRNSWPLIGDAAGIAVVENDPEADGIPTVIYNNGGLGQALMIPAGGSRMPSTPETARSEDRDGDGNLRALDNLTMQGADVFNFMQTKVPPLIEETLAYAGLTKEQIDWYLFHQPNRFMLRKLAEKLGVPYEKMPMNVVEELGNSSGACIPVCAVHNLAEELRAPEERTCCLAAFGSGLMWGAMIVKLGGMRFCEMLTSDL
>NZ_KE159711.1|WP_016323963.1|64857_65091_-|acyl-carrier-protein
MKTILQILSGLRPEFDFSSSRDFIDDGYLDSFDIVALISELEETFHILIDGMDVLPENFCSVEAIAATVRKNGGTLD
>NZ_KE159711.1|WP_155979098.1|65101_65821_-|GNAT-family-N-acetyltransferase
MLTVLTELSEREDTRLIYNEHAIALIYDDNGVTRLYLDLSSLEAAPALRELLGQICARPIIIDCVGSAERVEEVSLALCTAGFAPYAHLRRLRNTNIQYHPEADAVIQPALPEDCEPIFSLLCETFDPYVSHLPSREKLLRLINDQLVYRIVENGEIAAVQCLERTGTRGLYIYQTLVAPPYRGRGLGTLVIPYIPGCCAGSCSFFTVWVIDGNERSVRVLQRSGAVFDGLEDTVLIFR
>NZ_KE159711.1|WP_016323965.1|66001_66969_-|hypothetical-protein
MSINLRKANSLAVFGSGTIAARCVKLLRDMVDAEIYVYEKKQSNVSILERSLSHIAGVHYGEVGEGLEAEILEVNPAVIFSINNVYLFPGSLAERVPILNYHNSLLPKHPGRNAEAWTIFSQDQTAGVTWHFVDAHVDTGNIVAQREILLSPHITSIRLLSLQTQTAFNMFQEILNDLCRGEELPRRKQEERKDIKFHFSWERPNDGMLSLAWDISQTYAFLRAMDYGKLALLGVPLLEYDGIRYSWERYALEPSPGDAAFSLDLLHDTCTISRDGESVRLFGLKQDTSQKCDQEKGEESAMFDMQELLARKEGRKEGRKEG
>NZ_KE159711.1|WP_016323966.1|66983_68501_-|amino-acid-adenylation-domain-containing-protein
MIKNILEYFERTLAEAPEKTAVIDGEREITFAELSGNALALAAQLRRKSHGQIRQPVAVYLPKSIESITSDLGIVYSGNAYMNLDVKTPGRRIANILDLVDPLFVITDGKHQAALSAVWPEDRTVLVDGQIPRAGAEEELQRALEDVIDTDPLCLINTSGSTGTPKSVVLNHRSFIDYTTWAIETLGLRQDDIAGSIAPIVFDHFSYEFCLMLVRGCTLLLIPENYPSFPARLLQFLQERHATYLFWVPTIMVNIANMDLLSRIPLPEVRMVWFAGEVFPTKQFNYWRRQLPQATFVNLYGPTEITVDCTYYVADRPLRDDEPIPIGKPCRNTDILILNGENRLVSPGEEGELCVRGSSLAMGYYNNPEKTAAVFVQNPLNTAYPELIYRTGDIVYINEEGEIVYKGRNDSLIKHMGKRVELGEIEHVIVNTLQLVRNGCAVYDHGKKEIVFFYEAPKELEAAVLRREIGRQLPQYMVPGRFIHMELLPRNTNGKIDRLRLREGI

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_KE159711_2	2.7\|58046\|35\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	58046-58080	35	MH539650	Siphoviridae sp. isolate ctcf5, complete genome	18474-18508	3	0.914
NZ_KE159711_1	1.14\|56503\|33\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	56503-56535	33	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	4936087-4936119	7	0.788
NZ_KE159711_2	2.5\|57912\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57912-57945	34	AP013380	Uncultured Mediterranean phage uvMED DNA, complete genome, group G14, isolate: uvMED-CGR-U-MedDCM-OCT-S31-C41	21322-21355	7	0.794
NZ_KE159711_1	1.14\|56503\|33\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	56503-56535	33	NZ_CP021032	Rhizobium sp. NXC14 plasmid pRspNXC14b, complete sequence	263461-263493	8	0.758
NZ_KE159711_2	2.2\|57711\|33\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57711-57743	33	NZ_CP032350	Azospirillum brasilense strain MTCC4039 plasmid p5, complete sequence	174178-174210	8	0.758
NZ_KE159711_2	2.5\|57912\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57912-57945	34	NC_006903	Onion yellows phytoplasma plasmid unknown, complete sequence	12-45	8	0.765
NZ_KE159711_2	2.5\|57912\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57912-57945	34	NC_019167	Onion yellows phytoplasma plasmid EcOYNIM_1998, complete sequence	12-45	8	0.765
NZ_KE159711_2	2.5\|57912\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57912-57945	34	NC_019168	Onion yellows phytoplasma plasmid EcOYNIM_1999, complete sequence	12-45	8	0.765
NZ_KE159711_2	2.5\|57912\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57912-57945	34	NC_019169	Onion yellows phytoplasma plasmid EcOYNIM_2000, complete sequence	12-45	8	0.765
NZ_KE159711_2	2.5\|57912\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57912-57945	34	NC_019170	Onion yellows phytoplasma plasmid EcOYNIM_2002-2004, complete sequence	12-45	8	0.765
NZ_KE159711_2	2.5\|57912\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57912-57945	34	NC_019171	Onion yellows phytoplasma plasmid EcOYNIM_2005, complete sequence	12-45	8	0.765
NZ_KE159711_2	2.15\|58584\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	58584-58617	34	NZ_CP019881	Komagataeibacter nataicola strain RZS01 plasmid pKNA06, complete sequence	11054-11087	8	0.765
NZ_KE159711_1	1.14\|56503\|33\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	56503-56535	33	MK411746	Arthrobacter phage Sonali, complete genome	32481-32513	9	0.727
NZ_KE159711_1	1.2\|55697\|35\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	55697-55731	35	NZ_CP024314	Rhizobium sp. NXC24 plasmid pRspNXC24c, complete sequence	2159503-2159537	10	0.714
NZ_KE159711_2	2.5\|57912\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57912-57945	34	NC_012088	Onion yellows phytoplasma plasmid EcOYW1, complete sequence	12-45	10	0.706
NZ_KE159711_2	2.5\|57912\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57912-57945	34	NZ_CP035396	Bacillus subtilis strain SRCM103697 plasmid unnamed1, complete sequence	27943-27976	10	0.706
NZ_KE159711_2	2.5\|57912\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	57912-57945	34	NZ_CP032856	Bacillus subtilis subsp. subtilis strain PJ-7 plasmid unnamed1, complete sequence	20810-20843	10	0.706
NZ_KE159711_2	2.9\|58182\|34\|NZ_KE159711\|PILER-CR,CRISPRCasFinder,CRT	58182-58215	34	NZ_CP008890	Dermacoccus nishinomiyaensis strain M25 plasmid unnamed, complete sequence	24698-24731	10	0.706

1. spacer 2.7|58046|35|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to MH539650 (Siphoviridae sp. isolate ctcf5, complete genome) position: , mismatch: 3, identity: 0.914

tgtcccgcagggctggcgggtgctccgtgtacttt	CRISPR spacer
taccccgcagggctggcgggcgctccgtgtacttt	Protospacer
*..*****************.**************

2. spacer 1.14|56503|33|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 7, identity: 0.788

gtgaagacccggtcgtcggccttggcgacgatg	CRISPR spacer
ccgatcacccggtcgtcgaccttggtgacgacg	Protospacer
 .**  ************.******.*****.*

3. spacer 2.5|57912|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to AP013380 (Uncultured Mediterranean phage uvMED DNA, complete genome, group G14, isolate: uvMED-CGR-U-MedDCM-OCT-S31-C41) position: , mismatch: 7, identity: 0.794

--ctcttgaaccattctttcttttttaatattggca	CRISPR spacer
tgctgctga--cattcttccttttttaatattagct	Protospacer
  ** .***  *******.*************.**

4. spacer 1.14|56503|33|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP021032 (Rhizobium sp. NXC14 plasmid pRspNXC14b, complete sequence) position: , mismatch: 8, identity: 0.758

gtgaagacccggtcgtcggccttggcgacgatg	CRISPR spacer
gagaagaccaggttgtcggccttggccggggcg	Protospacer
* ******* ***.************ . *..*

5. spacer 2.2|57711|33|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032350 (Azospirillum brasilense strain MTCC4039 plasmid p5, complete sequence) position: , mismatch: 8, identity: 0.758

gtgaaggttttccgcgccggaggctccggcctc	CRISPR spacer
atgcgggttttccgcgccgggcgctccggtccg	Protospacer
.** .***************. *******.*.

6. spacer 2.5|57912|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NC_006903 (Onion yellows phytoplasma plasmid unknown, complete sequence) position: , mismatch: 8, identity: 0.765

ctcttgaaccattctttcttttttaatattggca	CRISPR spacer
agcttgaaacattgtttcttttttaatattattt	Protospacer
  ****** **** ****************. .

7. spacer 2.5|57912|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NC_019167 (Onion yellows phytoplasma plasmid EcOYNIM_1998, complete sequence) position: , mismatch: 8, identity: 0.765

ctcttgaaccattctttcttttttaatattggca	CRISPR spacer
agcttgaaacattgtttcttttttaatattattt	Protospacer
  ****** **** ****************. .

8. spacer 2.5|57912|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NC_019168 (Onion yellows phytoplasma plasmid EcOYNIM_1999, complete sequence) position: , mismatch: 8, identity: 0.765

ctcttgaaccattctttcttttttaatattggca	CRISPR spacer
agcttgaaacattgtttcttttttaatattattt	Protospacer
  ****** **** ****************. .

9. spacer 2.5|57912|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NC_019169 (Onion yellows phytoplasma plasmid EcOYNIM_2000, complete sequence) position: , mismatch: 8, identity: 0.765

ctcttgaaccattctttcttttttaatattggca	CRISPR spacer
agcttgaaacattgtttcttttttaatattattt	Protospacer
  ****** **** ****************. .

10. spacer 2.5|57912|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NC_019170 (Onion yellows phytoplasma plasmid EcOYNIM_2002-2004, complete sequence) position: , mismatch: 8, identity: 0.765

ctcttgaaccattctttcttttttaatattggca	CRISPR spacer
agcttgaaacattgtttcttttttaatattattt	Protospacer
  ****** **** ****************. .

11. spacer 2.5|57912|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NC_019171 (Onion yellows phytoplasma plasmid EcOYNIM_2005, complete sequence) position: , mismatch: 8, identity: 0.765

ctcttgaaccattctttcttttttaatattggca	CRISPR spacer
agcttgaaacattgtttcttttttaatattattt	Protospacer
  ****** **** ****************. .

12. spacer 2.15|58584|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP019881 (Komagataeibacter nataicola strain RZS01 plasmid pKNA06, complete sequence) position: , mismatch: 8, identity: 0.765

atcagcctgtcctggccgtttagag----cttgggaca	CRISPR spacer
aacagcctgtccgggccgtttagggccatctcgg----	Protospacer
* ********** **********.*    **.**

13. spacer 1.14|56503|33|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to MK411746 (Arthrobacter phage Sonali, complete genome) position: , mismatch: 9, identity: 0.727

gtgaagacccggtcgtcggccttggcgacgatg	CRISPR spacer
tcgcggacccggtctccggccttggcgacggcc	Protospacer
 .* .********* .**************..

14. spacer 1.2|55697|35|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024314 (Rhizobium sp. NXC24 plasmid pRspNXC24c, complete sequence) position: , mismatch: 10, identity: 0.714

ctggaggagaagtttaaggtgaagccagccctagg-----	CRISPR spacer
ttggaggagaagttttcggtgaag-----cctggaaggta	Protospacer
.**************  *******     ***.*.

15. spacer 2.5|57912|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NC_012088 (Onion yellows phytoplasma plasmid EcOYW1, complete sequence) position: , mismatch: 10, identity: 0.706

ctcttgaaccattctttcttttttaatattggca	CRISPR spacer
agcttgaaacattgtttcttttttaactttattt	Protospacer
  ****** **** ************. **. .

16. spacer 2.5|57912|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP035396 (Bacillus subtilis strain SRCM103697 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.706

ctcttgaaccattctttcttttttaatattggca	CRISPR spacer
caaacaaacaattctttcatttttaatattctcc	Protospacer
*   ..*** ******** ***********  *

17. spacer 2.5|57912|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032856 (Bacillus subtilis subsp. subtilis strain PJ-7 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.706

ctcttgaaccattctttcttttttaatattggca	CRISPR spacer
caaacaaacaattctttcatttttaatattctcc	Protospacer
*   ..*** ******** ***********  *

18. spacer 2.9|58182|34|NZ_KE159711|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP008890 (Dermacoccus nishinomiyaensis strain M25 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.706

aattctccagcttctccgcgtccagcctgatgaa	CRISPR spacer
gaagcttcagcttctccgcttccagcctcgcgtt	Protospacer
.*  **.************ ******** ..*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

177398 : 208848

Bacillus_phage(25.0%)

tRNA,integrase

attL 194378:194393|attR 214942:214957

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016324055.1\|177398_178568_+\|integrase	site-specific integrase	A0A1B0T6A8	Bacillus_phage	9.7e-37	32.3
WP_016324056.1\|178525_179959_+\|integrase	site-specific integrase	A0A1C8E994	Bacillus_phage	1.1e-34	29.4
WP_016324057.1\|180265_181411_+\|integrase	site-specific integrase	S5MNZ2	Brevibacillus_phage	6.1e-36	29.1
WP_016324058.1\|181421_182840_+\|integrase	site-specific integrase	S5MNZ2	Brevibacillus_phage	1.9e-34	28.1
WP_016324059.1\|183197_184016_+	amidohydrolase	NA	NA	NA	NA
WP_081646427.1\|184194_184473_+	HPr family phosphocarrier protein	NA	NA	NA	NA
WP_016324061.1\|184580_185165_-	hypothetical protein	NA	NA	NA	NA
WP_155979103.1\|185322_186459_+	DUF4118 domain-containing protein	NA	NA	NA	NA
WP_016324063.1\|186455_187163_+	response regulator transcription factor	W8CYM9	Bacillus_phage	1.4e-27	30.1
WP_016324064.1\|187225_187537_+	methylated-DNA--[protein]-cysteine S-methyltransferase	NA	NA	NA	NA
WP_016324065.1\|187604_187886_-	Dabb family protein	NA	NA	NA	NA
WP_016324066.1\|187937_189137_-	pyridoxal phosphate-dependent aminotransferase	NA	NA	NA	NA
WP_016324067.1\|189764_192353_-	DNA translocase FtsK	S5VNE3	Mycobacterium_phage	2.6e-82	46.9
WP_016324068.1\|192422_192875_-	hypothetical protein	NA	NA	NA	NA
WP_155979104.1\|192886_193732_-	undecaprenyl-diphosphate phosphatase	NA	NA	NA	NA
WP_016324070.1\|193933_194341_+	hypothetical protein	NA	NA	NA	NA
194378:194393	attL	NA	NA	NA	NA
WP_016324071.1\|194453_195137_-	ribonuclease III	A0A2K9L5P0	Tupanvirus	1.5e-26	37.0
WP_016324072.1\|195187_195433_-	acyl carrier protein	NA	NA	NA	NA
WP_016324073.1\|195504_196539_-	phosphate acyltransferase PlsX	NA	NA	NA	NA
WP_016324074.1\|196535_197843_-\|tRNA	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	NA	NA	NA	NA
WP_016324075.1\|197993_198206_-	helix-turn-helix transcriptional regulator	A0A0A7RUJ5	Clostridium_phage	1.3e-08	43.3
WP_016324076.1\|198282_198531_+	hypothetical protein	NA	NA	NA	NA
WP_016324077.1\|198527_200837_-	type I DNA topoisomerase	A0A1V0SB35	Catovirus	2.4e-95	35.3
WP_016324078.1\|201005_202184_-	DNA-protecting protein DprA	S6BFL3	Thermus_phage	3.0e-22	36.2
WP_016324079.1\|202328_203102_-	RNA methyltransferase	NA	NA	NA	NA
WP_081646428.1\|203301_203667_-\|integrase	tyrosine-type recombinase/integrase	H7BUX8	unidentified_phage	1.0e-29	68.4
WP_081646440.1\|203718_204180_-\|integrase	tyrosine-type recombinase/integrase	H7BUX8	unidentified_phage	7.4e-57	67.3
WP_081646429.1\|204207_204765_-	hypothetical protein	H7BUX8	unidentified_phage	1.6e-53	63.7
WP_081646430.1\|204796_205012_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_016324084.1\|206164_206863_+	response regulator transcription factor	W8CYM9	Bacillus_phage	4.3e-24	31.4
WP_016324085.1\|206859_208089_+	two-component sensor histidine kinase	A0A2K9L0Z8	Tupanvirus	2.8e-10	23.2
WP_016324086.1\|208152_208848_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.5e-34	38.4
214942:214957	attR	NA	NA	NA	NA

DBSCAN-SWA_2

327376 : 334648

Erysipelothrix_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016324214.1\|327376_327745_+	type II toxin-antitoxin system PemK/MazF family toxin	A0A2P0ZKX3	Lactobacillus_phage	3.7e-11	35.1
WP_016324216.1\|327988_329578_+	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	1.4e-78	35.2
WP_016324217.1\|329574_330426_+	hypothetical protein	A0A288WG52	Bacillus_phage	1.1e-05	40.5
WP_016324218.1\|330422_330983_+	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	1.3e-28	46.7
WP_016324220.1\|331299_332085_+	ParA family protein	F0PIG8	Enterococcus_phage	3.0e-18	32.2
WP_016324221.1\|332081_332993_+	ParB/RepB/Spo0J family partition protein	NA	NA	NA	NA
WP_016324222.1\|333008_333455_+	hypothetical protein	NA	NA	NA	NA
WP_016324223.1\|333622_334648_+	replication initiator protein A	M1PFC4	Streptococcus_phage	9.1e-15	39.8

DBSCAN-SWA_3

367470 : 375775

Ochrobactrum_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016324250.1\|367470_368325_+	ParB N-terminal domain-containing protein	A0A219VHB6	Ochrobactrum_phage	1.9e-18	34.0
WP_016324251.1\|368314_368656_+	hypothetical protein	NA	NA	NA	NA
WP_081646443.1\|368664_369027_+	hypothetical protein	NA	NA	NA	NA
WP_016324253.1\|369142_369895_+	hypothetical protein	C9WB95	Streptococcus_virus	8.4e-34	53.5
WP_016324254.1\|369891_370758_+	ATP-binding protein	H7BWC4	unidentified_phage	2.7e-44	51.7
WP_016324255.1\|370770_370950_+	hypothetical protein	NA	NA	NA	NA
WP_016324256.1\|371040_372960_+	recombinase family protein	D2XR37	Bacillus_phage	9.3e-21	27.5
WP_016324258.1\|373668_374088_+	hypothetical protein	NA	NA	NA	NA
WP_016324259.1\|374089_374530_+	hypothetical protein	Q6JIG5	Burkholderia_virus	4.6e-40	57.9
WP_016324260.1\|374545_375355_+	DUF3849 domain-containing protein	NA	NA	NA	NA
WP_040656260.1\|375355_375775_+	PrgI family protein	E4ZFJ8	Streptococcus_phage	4.4e-16	38.8

DBSCAN-SWA_4

385342 : 401572

Streptococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_051147127.1\|385342_387418_+	type IA DNA topoisomerase	A0A1X9I6W8	Streptococcus_phage	1.0e-44	30.4
WP_155979117.1\|387414_387822_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_016324271.1\|387826_388237_+	DUF4316 domain-containing protein	NA	NA	NA	NA
WP_016324272.1\|388241_388520_+	hypothetical protein	NA	NA	NA	NA
WP_040656262.1\|388678_389470_-	hypothetical protein	NA	NA	NA	NA
WP_155979125.1\|389474_389834_+	TnpV protein	A0A1B0RXG6	Streptococcus_phage	1.2e-14	37.7
WP_081646438.1\|389761_397687_+	DEAD/DEAH box helicase family protein	A0A248SL14	Klebsiella_phage	1.6e-239	43.7
WP_016324275.1\|397738_398182_+	recombinase family protein	W8CYE4	Bacillus_phage	5.1e-07	27.3
WP_016324276.1\|398286_399924_-	recombinase family protein	A0A288WFZ3	Bacillus_phage	3.1e-25	24.3
WP_002578909.1\|399907_401572_-	recombinase family protein	E5DV73	Deep-sea_thermophilic_phage	1.6e-29	25.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_KE159712

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_KE159712_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159712_1

6466-6551

Orphan

Consensus_repeat	Method
TTAGAATTAGCTTGAGCTTTTTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_KE159712_1

>merge|NZ_KE159712|1|6466-6551|CRISPRCasFinder
TTAGAATTAGCTTGAGCTTTTTTGATTTACCTCGCGTTTTTTGAGTTTCATTTCCGCAGCTTTTAGAATTAGCTTGAGCTTTTTGC

>NZ_KE159712|1|1|6466-6551|CRISPRCasFinder
TTAGAATTAGCTTGAGCTTTTTTG	ATTTACCTCGCGTTTTTTGAGTTTCATTTCCGCAGCTT
TTAGAATTAGCTTGAGCTTTTTGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159712.1\|WP_016324296.1\|15068_15542_-\|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl\|CDD\|224511
NZ_KE159712.1\|WP_016324291.1\|10410_11166_-\|helix-turn-helix-transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
NZ_KE159712.1\|WP_016324280.1\|239_548_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324290.1\|9587_10361_+\|RNA-polymerase-sporulation-sigma-factor-SigG	unknown	unknown	gnl\|CDD\|181296
NZ_KE159712.1\|WP_016324284.1\|3535_5284_-\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NZ_KE159712.1\|WP_016324282.1\|1852_2209_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324287.1\|7205_8123_-\|elongation-factor-Ts	unknown	unknown	gnl\|CDD\|236491
NZ_KE159712.1\|WP_016324295.1\|14077_15094_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324293.1\|12152_12947_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
NZ_KE159712.1\|WP_016324281.1\|614_1850_-\|TniQ-family-protein	unknown	unknown	gnl\|CDD\|377670
NZ_KE159712.1\|WP_016324294.1\|12971_13865_+\|NAD-binding-protein	unknown	unknown	gnl\|CDD\|183197
NZ_KE159712.1\|WP_016324289.1\|9092_9377_-\|YlmC/YmxH-family-sporulation-protein	unknown	unknown	gnl\|CDD\|274339
NZ_KE159712.1\|WP_016324288.1\|8174_8903_-\|30S-ribosomal-protein-S2	unknown	unknown	gnl\|CDD\|235396
NZ_KE159712.1\|WP_155979126.1\|11339_12323_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|223736
NZ_KE159712.1\|WP_016324283.1\|2186_3539_-\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379165
NZ_KE159712.1\|WP_016324286.1\|5936_6338_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_KE159712.1\|WP_016324296.1\|15068_15542_-\|sigma-70-family-RNA-polymerase-sigma-factor	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	1.33458e-26
NZ_KE159712.1\|WP_016324291.1\|10410_11166_-\|helix-turn-helix-transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	8.8125e-14
NZ_KE159712.1\|WP_016324290.1\|9587_10361_+\|RNA-polymerase-sporulation-sigma-factor-SigG	gnl\|CDD\|181296	PRK08215, PRK08215, RNA polymerase sporulation sigma factor SigG.	5.22649e-163
NZ_KE159712.1\|WP_016324284.1\|3535_5284_-\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	1.26634e-09
NZ_KE159712.1\|WP_016324287.1\|7205_8123_-\|elongation-factor-Ts	gnl\|CDD\|236491	PRK09377, tsf, elongation factor Ts; Provisional.	9.38781e-126
NZ_KE159712.1\|WP_016324293.1\|12152_12947_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	9.68629e-30
NZ_KE159712.1\|WP_016324288.1\|8174_8903_-\|30S-ribosomal-protein-S2	gnl\|CDD\|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	2.7069e-165
NZ_KE159712.1\|WP_016324294.1\|12971_13865_+\|NAD-binding-protein	gnl\|CDD\|183197	PRK11559, garR, tartronate semialdehyde reductase; Provisional.	2.63594e-77
NZ_KE159712.1\|WP_016324289.1\|9092_9377_-\|YlmC/YmxH-family-sporulation-protein	gnl\|CDD\|274339	TIGR02888, conserved_hypothetical_protein, sporulation protein, YlmC/YmxH family. Members of this family belong to the broader family of PRC-barrel domain proteins (see pfam05239), but are found only in endospore-forming bacteria of the Firmicutes lineage. Most such species have exactly two members of this family and all have at least one; the function is unknown. One of two members from Bacillus subtilis, YmxH, is strongly induced by the mother cell-specific sigma-E factor. [Cellular processes, Sporulation and germination].	6.69213e-22
NZ_KE159712.1\|WP_016324281.1\|614_1850_-\|TniQ-family-protein	gnl\|CDD\|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	1.42255e-21
NZ_KE159712.1\|WP_155979126.1\|11339_12323_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	5.39608e-20
NZ_KE159712.1\|WP_016324283.1\|2186_3539_-\|AAA-family-ATPase	gnl\|CDD\|379165	pfam13401, AAA_22, AAA domain.	1.30607e-09

>NZ_KE159712.1|WP_016324286.1|5936_6338_-|hypothetical-protein
MEKANLKAREYRFFSQKNQKMICLHSEQALAYARYLEDRLWVAAYEACVPLELTDQIDPWGIRPLYFKTAWVSDFHLVYTDGKQAVRELVRLEDLKKQAIIERLELSRRYWMGVAFSHPVEWKVEVVDYKKSL
>NZ_KE159712.1|WP_016324284.1|3535_5284_-|DDE-type-integrase/transposase/recombinase
MNRYVERNGEVFHVLLQEDAGAWLISCQAPAEPFFVAQIEAFNPLEASSLTEALCPHEALSPHEAESLMSPGQVKRLRLIQLLLGDSRCITDKAYRSALAKETAGRNGTTSRRILRLYYRYLATGKLMQERRREPSENKVYDWAIRTFYFSAKKLSLRAAYEMMLVQKYTDAKGILLPDAPTWSSFQHYFYAHNYHKQPQKIIARDGLSHYQRNCRPAFGSASRWRESPGSYQMDATQGDLYLVSSLDRSSIVGRPQIYMAVDSATQLIAGIYVGYEAGERAVMACLENAACGKVDFCRKYGIEIQPEQWPSQGLPSEIITDKGREFTGSRMEELCRRYGVELLIQPPFRPDGKGLVEKAFDLLQQRYKPLLRGKGVIEPDAQERWAVDYRSQAVLTLEEFTQIVIQCVIYLNSGRVLQSGMTPAQVWLKAMRWLSATGSATGSATTSATVWKVQDVPSKELHVLSLPREEVKLTRKGFRLHALSYVPQNMDGLYVGDTYTLAYDTLDLSAVFLIGKDRDSRIPLAPNQQQYQGLSQAEAEICREQERQARKQAKAAETQASIQTIQGIQKIVKEAERRRQE
>NZ_KE159712.1|WP_016324283.1|2186_3539_-|AAA-family-ATPase
MNKDLGNPLLTAMPKMLAPQELTQAVQSLPPLPAAPSLEGLALLSSIFIPMDYMYTLYDQLYRAIRTTYTTRTVLEGIRQTNALFRGDAGTCCATQAAAGSVLGVPGIGKTSTIRRCLDTMPQVIEHTDFEGQPFFCKQVLYLRVECPSDCSVKTLALNLVAALDRAIGSNYLHQLTALRSAAASAIAAQVKILCMTHHVGLILVDEIQNAVVTAQKNKQVKPLIKFLVELTNDTCTGVFFVGTPQAEELFTSQEHLKRRTRGIRLLPLKPDGVYRNFLKLLWQYQLTPERAELTEALANKLYDWSGGIPAYIVKIFQESQAQAFLMGRPCIDAKIMQQAINILAIKVPKTYAGGTYLSDFPPIGFQPIQPAEESCKSPAGLMAGCKKAGCKPVERKRLYAKKRGRKAAVREEQDLLAAFKAGADMLEHLARFNLLGKEREDENGASEDG
>NZ_KE159712.1|WP_016324282.1|1852_2209_-|hypothetical-protein
MELQKMVEYAKALKPEDMEWKPLYPNNMPGNGLMGYAACLELPDGSGGRYYTILLQYKEDERGCMLEGVELYVLFERVRSGSDSFVRAFRTLDEAKARAVLQFQMVYGYAMSYLADDT
>NZ_KE159712.1|WP_016324281.1|614_1850_-|TniQ-family-protein
MLTYFPMPYPGEWWYSVLCRYHVRSGNIKQQTTIRELFPGRITAAISSIFPNSTIRQVIEQLPSDWLLPEAVITQNTLFPYYTRFFLAEKKTALLEKACLGETPTITSLRRSANLSKWRPRYCPQCAEEDRAIYGEAYWHIEHQIPFLKICPNHKCSLYVLEEIQPSHLGYTFYPLEAQVLCLDKCKDIPLWQRTVASILWEYETLPLKPAIAENHNHIAACLSNMGYGVIQNHSPNVILDAKRLYQDMADYYSPEVMEDIFGDVCIINRACKWGTASPERYALLQSFAGVSSETVFSDRPVSDHYADELKVLQCSGTHLTKKQVLEQLSVTPSQLNILLKKYHLEPFWRQMGGECAELGRHRFSFALNDEEFARFKQALRKSGYRYDSHFIRQCVMAYIDANQKEGSGDS
>NZ_KE159712.1|WP_016324280.1|239_548_-|hypothetical-protein
MNQYEKAEIVARCVAHLAWQAWLPVREVAACIGPERMEELMDFAPCREFMSIDEMAWEINRGCWLGYELDKDAPLPPEDFGEKTVQRMEDDGLDLYTALVKA
>NZ_KE159712.1|WP_016324287.1|7205_8123_-|elongation-factor-Ts
MAFTAADVKNLREKTGVGMMDCKKALAASDGDMDKAIEYLREKGLAASVKKADRIAAEGMAYAAVVNGVGVVVEVNAETDFVGKNEKFVDFVKGVAATVAAANPADLDALMECKYNGTDLTVLQQQQEMVLVIGENIKVRRFARFEGGVCVPYVHAGGKIGVLVNLDTDLPAEKVEEAGKDVAMQIAALNPRFWDKAQVTQDVLDEEKKIMMAQMENDPKMASKPEQVREKIVLGKLHKFYTENCLLQQEFVKDGDLTVEKYLAAAAKSLGGTITFKDAVRFEKGEGIEKKQENFAEEIASMVKG
>NZ_KE159712.1|WP_016324288.1|8174_8903_-|30S-ribosomal-protein-S2
MANSSVVSMKALLEAGVHFGHQTRRWNPKMAPYIYTERNGIYIVDLQKTVRKLEEAYNFVRQLSESGQALLFVGTKKQAQDAIREEANRCGQYFVNARWLGGMMTNFKTMRTRVDRLNQLKTMQEDGTFDMLPKKEVMKHMGEIAKLEKYLGGVKEMKRLPGALFIVDTRKERNAIAEAHKLGIPVVAIADTNCDPDEIDYVIPGNDDAIRAIKLISSIMANAVLEGKQGEQTEEPEKADAE
>NZ_KE159712.1|WP_016324289.1|9092_9377_-|YlmC/YmxH-family-sporulation-protein
MQCRIRGLQRKEVINICDGCRLGFVSDVDIKVPEGQVVAIVVSGPKLFFGLFGRGEEFYIPWDCIQRIGDDIILIDKPFQRRDPNLEKKRRRRC
>NZ_KE159712.1|WP_016324290.1|9587_10361_+|RNA-polymerase-sporulation-sigma-factor-SigG
MQGKVEIAGVNTSKLKVLKNEETMALLRRTKEGDQEARRQLIEGNLRLVLSVIQRFSGRGENADDLFQVGCVGLIKAIDNFDITQPVRFSTYGVPMIIGEIRRYLRDNSAIRVTRSMRDTAYRVLQVRDRLLAESQREPTVEQIAKELDIPREDVVFAMDAIMDPVSLYDPVYSDNGGDTLCVMDQVRDTKNTDENWTDRIALKDAMKRLDDRERRILSLRFYEGKTQMEVSAEVGISQAQVSRLEKGAINTIKKNI
>NZ_KE159712.1|WP_016324291.1|10410_11166_-|helix-turn-helix-transcriptional-regulator
MNFSKKLADLRRREGFSQEQLAERLGVTRQSVSKWESGAAQPELAKLVALSELFRVSVDYLVKDCLEEQDRPAGQSASTAKLEAQVEEISRLFRVWSWDSKTKIRGLPLVSIRLSGNQMRLRDAARGIIAIGNIAVGVLSLGIMSVGVVSIGVISAGLLALGCLAFGLAAFGPVALGLWCAGGVTALGGKIAIGVAAVGETAVGYNAVGSHVLLWGDGLTRAQAESFLLEHHPGLWRPLLQFLAVLGANIK
>NZ_KE159712.1|WP_155979126.1|11339_12323_-|helix-turn-helix-domain-containing-protein
MAPQVNRDDLVFFRQRGDVVAKGLSALIPAVEQDQGLSRALNLIVDGDAVICCKGCHAVIPPDRFICPLDDLLLFFNKFLNKIVKCFTKLESLYIVYKYRRAILCGLRGGGFVKAKEANAMRYIPDLFRQYGLPRRFCAGQQIFLKDSPARELYFLERGKVRAYLLYPDGIERTLCFVEKGNLVGEEAVGRPAVRIVCADAAADSLMYSMDLDTLLRACAAERENWAELLALFMKKIELLSSWIFYAQFIQNSAKLACFLFSNTGNAHTVVRYTQEQIAAVTGMSRVSVSNLIRKFEEEGLVCQGYRSIRVLDRERLRALFGKREFY
>NZ_KE159712.1|WP_016324293.1|12152_12947_+|alpha/beta-hydrolase
MAAFTTNDGVSIHYEVQGTGKPLVLLHGWDQSGKAFCNNISALAEKYQVVTVDLRGHGESGKPSYGYRISRLAMDVKQLLDTLELEEVSLLGWFMGCSVVWSYWDLFRGDRLSKLILVDEPPLCLINSSNPDGFSNNSDLEDLKEALLKDTVNATKGFVDMMLYTPEGKARYSQQTLEESLKFPARECAHLLLNHVYTDWRDVIPTITLPTLVIAAKNSHVKVSNNQWTHAHIANSQFRLFETAHMMFMEEAGAFNAALMEFIG
>NZ_KE159712.1|WP_016324294.1|12971_13865_+|NAD-binding-protein
MKQIGFLGLGVMGLPMAINLVKRSGCSVLGYDVLPGQMDAFRAAGGAAAGDPAEIYQSCDIIFQILPTHPIIIHSVEQAIQYGKPGRIVADLSSTAPDIILDLFQKAQAAGMSLVDAPVSGGNPMAEAGTLAIMAGGERDAFETIKPLLSCMGTPVYTGGSASGSVTKLVNNMIGGAVLTAIAEGYAFAAKAGIDLQTTFDATRGGFAGGPLYDNKVPKLIRRDYKPGARIAVHRKDILNAKHYAHRLGVDLPITDVVLHVMDWMADNGHIDEDQIAMVKYYEEKMGVTVGQDSKSN
>NZ_KE159712.1|WP_016324295.1|14077_15094_-|hypothetical-protein
MDNSAYRNELDRIRYTAEGRAALAEQLMRAQSAERGRRSVRWPRKMMAVAIAAAVLVGTAAAAAGPLWERYFGHLDEGQQAVIDSLSATPETLPAAESNGTVMTPLAAFGDRDFYYLMLEIRAPEGTVLPDYGEEKGYYQLFGDVPGEKISLMDGDGQELYNNREFAWMPRTGEDNVLTAVLRLWPAEGVDFSDGTDKILHIPGLWVQSPDKVYTPVLTGSWDFNIGAHSGGVESRTPDVAGVTVESEDCGTMTLEYLRISPLGMRIRYSWSDPVEGVWPSAELAVVMKDGSEVSLANSVGSAGEDWSEAYGPFDTPVNIEQAAAVRWGDAIIPLEAD
>NZ_KE159712.1|WP_016324296.1|15068_15542_-|sigma-70-family-RNA-polymerase-sigma-factor
MVARWADTVLRIGYTWTGSMQDAQDVSQTVLLKLLTSPRRFDGEEQERAWVLRVAVNCCKDLKKSAWARRRVPLESAGEAAVELPEVEDSPVLRAVQALPEKYRQAVYLRYYEEYEVEEIADLMGCRAPQVSTYLYRGKQKLKIMLGGMYGQQCLSE

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Crispr_ID: NZ_KE159712_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159712_2

130779-130887

TypeV

Consensus_repeat	Method
GCGTGAGAGTTCTGCCCGCTGGCTA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_KE159712_2

>merge|NZ_KE159712|2|130779-130887|CRISPRCasFinder
GCGTGAGAGTTCTGCCCGCTGGCTATTGTACGTCGTCCTTCTGCGTGAGCCTGTAACCCACTGGCAACAGTATTAGAACCCTCTGCGTGAGAGTTCCGCCCGCTGGCTA

>NZ_KE159712|2|2|130779-130887|CRISPRCasFinder
GCGTGAGAGTTCTGCCCGCTGGCTA	TTGTACGTCGTCCTTCT
GCGTGAGCCTGTAACCCACTGGCAA	CAGTATTAGAACCCTCT
GCGTGAGAGTTCCGCCCGCTGGCTA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159712.1\|WP_016324416.1\|138489_139035_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324404.1\|127393_127822_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324405.1\|127959_128208_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324399.1\|122594_123542_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224093
NZ_KE159712.1\|WP_155979130.1\|125165_125438_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324403.1\|127070_127379_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324401.1\|125844_126855_-\|DUF882-domain-containing-protein	unknown	unknown	gnl\|CDD\|311960
NZ_KE159712.1\|WP_016324412.1\|134640_136995_-\|valyl-tRNA-synthetase	unknown	unknown	gnl\|CDD\|224117
NZ_KE159712.1\|WP_016324413.1\|137091_137244_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324402.1\|126847_127051_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|293550
NZ_KE159712.1\|WP_016324415.1\|138045_138486_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324408.1\|132044_132209_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324414.1\|137497_138049_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369109
NZ_KE159712.1\|WP_040656466.1\|123556_125032_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
NZ_KE159712.1\|WP_016324410.1\|133583_134261_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_081646451.1\|121548_122571_-\|substrate-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|380478
NZ_KE159712.1\|WP_016324406.1\|128220_129282_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324411.1\|134269_134632_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_040656419.1\|139035_139269_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159712.1\|WP_016324409.1\|132196_133591_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379398

Protein	Function_ID	Function_description	E-value
NZ_KE159712.1\|WP_016324402.1\|126847_127051_-\|hypothetical-protein	gnl\|CDD\|293550	pfam16945, Phage_r1t_holin, Putative lactococcus lactis phage r1t holin. Phage_r1t_holin is a family of putative phage r1t holins from lactococcus. these holins carry two hydrophobic putative TMs separated by a short beta-turn region.	0.006414
NZ_KE159712.1\|WP_016324414.1\|137497_138049_-\|hypothetical-protein	gnl\|CDD\|369109	pfam06854, Phage_Gp15, Bacteriophage Gp15 protein. This family consists of bacteriophage Gp15 proteins and related bacterial sequences. The function of this family is unknown.	8.00207e-14
NZ_KE159712.1\|WP_040656466.1\|123556_125032_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
NZ_KE159712.1\|WP_016324399.1\|122594_123542_-\|ABC-transporter-permease	gnl\|CDD\|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	1.62484e-85
NZ_KE159712.1\|WP_081646451.1\|121548_122571_-\|substrate-binding-domain-containing-protein	gnl\|CDD\|380478	cd01536, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of active transport systems that are members of the type 1 periplasmic binding protein (PBP1) superfamily. Periplasmic sugar-binding domain of active transport systems that are members of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this family function as the primary receptors for chemotaxis and transport of many sugar based solutes in bacteria and archaea. The sugar binding domain is also homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR. Moreover, this periplasmic binding domain, also known as Venus flytrap domain, undergoes transition from an open to a closed conformational state upon the binding of ligands such as lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. This family also includes the periplasmic binding domain of autoinducer-2 (AI-2) receptors such as LsrB and LuxP which are highly homologous to periplasmic pentose/hexose sugar-binding proteins.	1.42762e-75
NZ_KE159712.1\|WP_016324401.1\|125844_126855_-\|DUF882-domain-containing-protein	gnl\|CDD\|311960	pfam08291, Peptidase_M15_3, Peptidase M15.	4.00665e-29
NZ_KE159712.1\|WP_016324412.1\|134640_136995_-\|valyl-tRNA-synthetase	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	6.03795e-09
NZ_KE159712.1\|WP_016324409.1\|132196_133591_-\|hypothetical-protein	gnl\|CDD\|379398	pfam13884, Peptidase_S74, Chaperone of endosialidase. This is the very C-terminal, chaperone, domain of the bacteriophage protein endosialidase. It releases itself, via the serine-lysine dyad at the N-terminus, from the remainder of the end-tail-spike. Cleavage occurs after the threonine which is the final residue of the End-tail-spike family, pfam12219. The endosialidase protein forms homotrimeric molecules in bacteriophages. The catalytic dyad allows this portion of the molecule to be cleaved from the more N-terminal region such that the latter can fold and presumably bind to DNA.	5.11534e-06

>NZ_KE159712.1|WP_016324406.1|128220_129282_-|hypothetical-protein
MGVYIKDASGKRIKVAGGGSGAAGPSGQDGKSAYDYAVAGGYTGTEAAFQALMGSAPWVPEAGYVSASNPNLLDNWYFLDPINQRRIQSGVTWGSKVYGLDRWKSYAADATKWVENEGIYLLGIANAILEQSIETNRFGGQRQITFSALIGTTLLSFTQDYQTAGSFDTSVGGVRYALAAYAPSDGLKMFRVYRPSLDGEAVPVIAAKVELGDKQTLARKDAAGNWILADPPPNKATELAKCQRYQQVLNEGTYSSHSFGLGFATASDQVRVIHHLPVCMRKTPAVIVDGAFQLNLNMSTPTSQRVDVSNLDLVGSDLQTIVLRAYGTVTLGSIYALVSNSANPGRIILDANL
>NZ_KE159712.1|WP_016324405.1|127959_128208_-|hypothetical-protein
MNKLKNSIVIPELDLETSYNRHYVTVDSSGRITEGWSDGPHPERDPAGAVCINDQDGYQFRLFTGGEENPVLYTEDSIPLYR
>NZ_KE159712.1|WP_016324404.1|127393_127822_-|hypothetical-protein
MSGDPMAALASAIYLARLQLETLADTDDKRLRASGLYPEWAPGDHRQGERYNARDQTWECFSDYDNAVYPDIRPGEAAWYTFNRPLHGTSPETARPFVPVQGAHDLYRAGEYMIWTDGGMYRCLRDTNFSPEDSPADWEITE
>NZ_KE159712.1|WP_016324403.1|127070_127379_-|hypothetical-protein
MPDNCMESCPVIPRVDALEEANRQHGATHREMFNRLNALERSTDSQGVMLRNIDEKLDELKATVSALAEKPGKRWDGMVDKLIYLAAGAVVAWAAAGTPGLG
>NZ_KE159712.1|WP_016324402.1|126847_127051_-|hypothetical-protein
MSEHTKKWMKAAGIRAIKTVAQTAVATIGTAVLLTDVSWVAVASASVLAGALSLLTSVAGLPEVDYA
>NZ_KE159712.1|WP_016324401.1|125844_126855_-|DUF882-domain-containing-protein
MPNLCQTAIPLTAIRRVQVYINSPRKSLSAIKKATGADYIINGTLYNMSTGAVNCHLKADGKVIAKPGYTVYGLSWDTGKDMRMEVLPCPRRNYIACTPLIINGVSLAKLTYDPGQGGIRPRSAIGLQGDQLDLYCTTSGKTPERLRDELAKAGWTQAVMLDGGGSAQCDFAGQKITSSRKVQHLILVYLDQEPEEPKGEKPMVEINAYSKTKDSSKKLSANFTVKEFACSDGSDAVLVAPRLVMVLQSIRSHFGKAVTINSGYRTPQKNAAVGGAAQSQHCYGTAADIVVKGVAPAQVAAYAREIMPDWGGVGIYERQGFTHVDVREIKADWKGA
>NZ_KE159712.1|WP_155979130.1|125165_125438_-|hypothetical-protein
MKKVKTPKRWIFFRRSALMFPAIHKAGWRQIALTGKKSLAAAHFAIYQTGPKRLRELLLIFCPDHSGIFNGNSAFLLCNYSKKHLLFRIK
>NZ_KE159712.1|WP_040656466.1|123556_125032_-|sugar-ABC-transporter-ATP-binding-protein
MKNISKTFPGVVALDHVQLQVKPGEVHALMGENGAGKSTLMKILMGIYTRDPGGEILFDGKPYHAANPKEAMDTGIAMIHQELNPILDMTVYENIFVGRELRKNGLVDKKAEIEAAQKLIEECGLHVSPRETLRNLTVAQCQLIEIIKAISINAKVIIMDEPTAAITEREVELLFGHIRRLTEKGVAIIYISHRMAEIFSICDRVSVYRDGQYIGTDTTANLDETQLIKMMVGREITDVYPKLEVDVGEVIFEAKNIVRADQKVKNVSLAVRRGEILGIGGLVGAGRSELVEGIFGMQPLSGGEIYIKGRKVKVSSPRDIIKEGVALITEDRKVTGLNLSGSVNDNIAMVAIKKLLTHGLYNRAKALSASQEYIEKLHIKTPSGNQIVGNLSGGNQQKVVIAKWLLNEPDVIILDEPTRGIDVAAKRDIYLLLGDLVRQGKAVIMISSEIPELMGICDRIAVMCEGNYSGEVKREEFSQERIMTLASAIKV
>NZ_KE159712.1|WP_016324399.1|122594_123542_-|ABC-transporter-permease
MKETKRTKALLSEYFIFVIFIALVIVLTCLKPSFIQPGNLVNILKQASINGILAFGMMFVIIAGGFDMSVGSTVAFTGVLAAMLGQGEYPLIVPLIVAMIAGLAVGVVNGVGVAVGDLPPFIMTLGTMTAVRGLALLISNGKPVIGISAEYKAVAASSLFGIPMLAVFLVVIIVICSFVLAKTVYGRRVYACGGNLLAARVSGINTTKIRISTFAIAGLLAGLSGFLMTSRVTIGQPNAAESYEMDAITACVVGGVSMSGGVGKPWGVVVGCLLITVIANGLDIMGVSSHWQKIVKGAIIVLAVLLDIKGKSKKN
>NZ_KE159712.1|WP_081646451.1|121548_122571_-|substrate-binding-domain-containing-protein
MFCPPSLTYKLLRRKNHMNKKKFLAMLLASVMTLAVLAGCSSSPAATPADNNTPADAEDGAYKIALIQQHQTNAFQIAVTEAAEAKAAELGVELKILSADQDAATQISQIEQCVSEGYQAILFEPVDPDGLRDAAKNAADAGVVVINIISACTDWEDAGISAVSYGNNVKAGETEMQQVADLLGGKGNIAILTGPSADAGGLQRMEGYENILANYPDIVQVVSPADCAWDTAQAQSTVESWLSAYDLDAIICENDGMAVGAGNAAGANSGIIISGVDGTPDGFEAIKDGRITGTVSQNGGAMAANGIEAAVTLLSGGTLETNVLVTDNTWIDASNVADYE
>NZ_KE159712.1|WP_016324408.1|132044_132209_-|hypothetical-protein
MEELKKEMNAAYKLMDAIPVRGDMIEVMAEARRHLREAYKLAENLEERQEGKHG
>NZ_KE159712.1|WP_016324409.1|132196_133591_-|hypothetical-protein
MYRFFVGDDITSVEDNGRQLPISRVTLKVDDESVLTAGDDTGMELEADCPHATQAMVNAILAKVKGYRYQMFSAGDAGLDPAAELGDGITAGGVYSVISRLSDDGSGFPSVTAPGEAELEDEYPAGGPMSREFDRKIAETRSSITKTAEQIRLEVANQVQGLSSSFTVELNSIKGQVTGLNGQVSTLEQTAESIILRVSGLDASVSTISQTVNSITLGVENGNSSSWIKLYKDGIEVASERIKFKGQVVFEDDLSSGETIISGDCIQTGEVSARYIRLGGAMDVYESLNSNAIGGTLGYVTSYDFHGNRTYGMGMLNYNDNYQVVVTDSGARLTSPTAEVVAAVNITLDTSRKINASTELTITSDLRKKEEVRYDVAEKYLPLLDRLKPCSFLRKDGGDQRHLGFIAQEYRDAETAAGISSEDSVIIGKTDGFYGLTYGEFIPLLVAKIQELNNRVKELESWKS
>NZ_KE159712.1|WP_016324410.1|133583_134261_-|hypothetical-protein
MAQSTSELWKTLIRSRDVTREYAFDIAGTWYGPEQEVSHTVESGLYEQFGIGNASTAKLTISLFAKDIPRTAAIKRFIRLREGEQATEWLPKGIFFANRRSDDSGYWTVEAYDAMRKAEAVWTPDQSLTFPMNMPAAAAEFARMMEVELDPRTVLNPAYTIDYPANDYTIRDELRFIAAAHGGNWIMTDEGKLLLVSLLSIPPETSYLVTEYGSAITLGGVKILV
>NZ_KE159712.1|WP_016324411.1|134269_134632_-|hypothetical-protein
MTVLFINGHDYTRYVADDGYDWSRDDLDSEKTKRVRSGKLRRDKITEKRNLTFKMLPMPEALAAQLDTDLHAATFNVKYRDLHGEQIREFYCSQFPAKLRQVVDKGNLLWDGISFNLHEI
>NZ_KE159712.1|WP_016324412.1|134640_136995_-|valyl-tRNA-synthetase
MANSTADGSVVIDVDINVNQAEKRLAKLRGNIKKVEKGIANITKAKEKAAQKSLFQAGELDAEKAKLQEIRDRLAEIRDLSKDKSADIGQRESHAGQISSVKQEYDEQKTRVNALQAEWNKTEDAIDSYNLKIDASTQKLGEMKTEAGILTQQIDEDAKKQDGDKPDPPTAKNVIGRLAKSFFGLDKGALDLNITSKALTAFQQLAMKYIKINDEARQAIAQLKGALLTLAQPLIEAIIPAFTVFLNVLFKVVTAVAAMVSALFGKTIKQSADGAEALDGEAKAISGVGSAADEASGSLAGFDEINQISTEDSNGGGGASAEIAPDFSWADNMDGIEERMREIADFVGLIAAGLLLWKIGTALPGVLGQIATKLGGVLLTVGGLLLFWHGLTDAWENGVDWLNLIEMVGGLAAAAAGLYITLGPVAAGIALVVGGIVMLVTGFRDAMQNGWNLQNMLLAIAGILATGAGIALMAGSWIPLLIAAIAAALLAITIATGHGEELLEGIRTVMQGFVDFFTGIFAGDIQKALGGISQIFDGLKTVVFAVIDGIKDSLLSFLEWLDEKTGGRFHGIIEAAKGFVTGFFGSTQETLGNILDSVKRIFTGITQFLTGVFTNDWDLAWEGVKNIFAVIWNGIISVLEGAINLIIKGINLLIGKINGLIGDGLFSKGLEYIGVPNGKIPTIPEAKIPRLAQGAVIPPNREFMAVLGDQRNGRNLEAPEDLIRKIVREESGGGDGQVVMLLQSLLEAVKAGQVIMVDKAVLGRTARDGINDITTKSGKFALLF
>NZ_KE159712.1|WP_016324413.1|137091_137244_+|hypothetical-protein
MGTEIERQDTRKAMAYDIIQILKENPEKQSYTTEEIEKIIHVYLTTADQK
>NZ_KE159712.1|WP_016324414.1|137497_138049_-|hypothetical-protein
MNWELPQSVEVQGASYPIRTDYRCILDILTDLSDPEADEQKRALAVLIGLYPDFDDMPPEHYEDALNEGVRFINCDSGDAPHKSPRLVDWEQDYSLMIAPINRVVGREVRSLEYMHWWTFLAAYNEIGDCTLAQVVRIRDHLARGKQLDKSDREWYRKNRHLVDFKRKYTSADDALMKEWGGT
>NZ_KE159712.1|WP_016324415.1|138045_138486_-|hypothetical-protein
MRELTFDSGVVSYSLNGKCEVSFNPADRAFAERFYNAVDEMGKLQDSYAKKAEEMNDPAGAFSLARRRDEEMQKVLDGLFDAPVCAAVFGDMSLCAFANGFPVWLNLMLAILDEIEANIGDIQKQADPRIAKYKAKYQKYSARYHK
>NZ_KE159712.1|WP_016324416.1|138489_139035_-|hypothetical-protein
MADNNFNTTPGQTIARELMIAYLNTGTDSSPVWSPFGRRTTDSSIEYDWSEDSSQDILGNTWTTMKKPTMSQSFDPWDLDGGDAAQQKIYQLAVIEQNAQALTNMDVMIAHFYSGSKEAAFAERYSACMVKPSSLGGEGGGNLGMPVDVTYGGERTVGTVSKGAGGAVTFTPAASATATED
>NZ_KE159712.1|WP_040656419.1|139035_139269_-|hypothetical-protein
MTGGTSVPGNTTSPDKRLKADELLDRLGDWVQRGTPDLGNGIRAMRVEATTRSSKFAEYENGDEDHQILMKMTYEVI

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_KE159712_2	2.2\|130846\|17\|NZ_KE159712\|CRISPRCasFinder	130846-130862	17	NZ_KE159711.1	66673-66689	2	0.882

1. spacer 2.2|130846|17|NZ_KE159712|CRISPRCasFinder matches to position: 66673-66689, mismatch: 2, identity: 0.882

cagtattagaaccctct	CRISPR spacer
cagaattggaaccctct	Protospacer
*** ***.*********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

5. NZ_KE159708

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

226279 : 250576

Bacillus_phage(66.67%)

transposase,integrase

attL 221177:221191|attR 260647:260661

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
221177:221191	attL	NA	NA	NA	NA
WP_016322549.1\|226279_227434_-\|integrase	site-specific integrase	A0A1B0T6A8	Bacillus_phage	5.2e-43	31.4
WP_016322550.1\|227433_227733_-	hypothetical protein	NA	NA	NA	NA
WP_016322551.1\|228039_229473_-\|integrase	site-specific integrase	S5MNZ2	Brevibacillus_phage	9.4e-34	29.4
WP_016322552.1\|229430_230600_-\|integrase	site-specific integrase	A0A1B0T6A8	Bacillus_phage	1.2e-34	31.7
WP_016322553.1\|230603_230900_-	hypothetical protein	NA	NA	NA	NA
WP_016322554.1\|231093_231261_+	hypothetical protein	NA	NA	NA	NA
WP_016322555.1\|231262_231874_+	hypothetical protein	NA	NA	NA	NA
WP_016322556.1\|232437_232872_-	hypothetical protein	NA	NA	NA	NA
WP_016322557.1\|232868_233081_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_016322560.1\|236142_236778_+	hypothetical protein	NA	NA	NA	NA
WP_016322561.1\|236960_237734_-	CAP domain-containing protein	NA	NA	NA	NA
WP_016322562.1\|238256_238985_-	hypothetical protein	NA	NA	NA	NA
WP_016322563.1\|238977_241194_-	hypothetical protein	NA	NA	NA	NA
WP_016322564.1\|241190_242051_-	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	2.5e-13	28.8
WP_016322565.1\|242118_243588_-	HAMP domain-containing sensor histidine kinase	W8CYF6	Bacillus_phage	3.8e-22	27.2
WP_016322566.1\|243565_244237_-	response regulator transcription factor	W8CYM9	Bacillus_phage	2.7e-39	40.0
WP_016322567.1\|244492_245272_-	CAP domain-containing protein	NA	NA	NA	NA
WP_155979006.1\|245789_246212_+	hypothetical protein	NA	NA	NA	NA
WP_040655478.1\|246204_246441_+	hypothetical protein	NA	NA	NA	NA
WP_016322572.1\|248043_249189_+\|integrase	site-specific integrase	A0A0U3U8Y8	Bacillus_phage	1.8e-35	33.1
WP_081646334.1\|249796_249982_-\|transposase	transposase	A0A1B1P773	Bacillus_phage	3.1e-06	41.7
WP_081646335.1\|249988_250576_-\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A0C5AC89	Paenibacillus_phage	2.6e-30	48.4
260647:260661	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

6. NZ_KE159709

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_KE159709_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159709_1

657356-657418

Orphan

Consensus_repeat	Method
CAAAAAGCTCAAGCTAATTCTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_KE159709_1

>merge|NZ_KE159709|1|657356-657418|CRISPRCasFinder
AGAGTAGCTCAAACTAATTGGAATTAACATGAGCTTTTTGGAATAGCTCAATTTAATTCGAGC

>NZ_KE159709|1|1|657356-657418|CRISPRCasFinder
AGAGTAGCTCAAACTAATTGGAA	TTAACATGAGCTTTTT
GGAATAGCTCAATTTAATTCGAGC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159709.1\|WP_016323380.1\|653462_653678_+\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|376355
NZ_KE159709.1\|WP_016323390.1\|662248_663484_+\|TniQ-family-protein	unknown	unknown	gnl\|CDD\|377670
NZ_KE159709.1\|WP_016323379.1\|653285_653435_+\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_KE159709.1\|WP_155979061.1\|652259_652925_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350617
NZ_KE159709.1\|WP_016323385.1\|656504_656873_+\|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl\|CDD\|234671
NZ_KE159709.1\|WP_016323377.1\|651826_652252_-\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|335420
NZ_KE159709.1\|WP_016323393.1\|664644_665226_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|366867
NZ_KE159709.1\|WP_155979039.1\|656960_657158_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159709.1\|WP_016323389.1\|661889_662246_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159709.1\|WP_016323387.1\|658802_660563_+\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NZ_KE159709.1\|WP_155979040.1\|658306_658798_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|394822
NZ_KE159709.1\|WP_016323388.1\|660559_661912_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379165
NZ_KE159709.1\|WP_016323391.1\|663549_663858_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159709.1\|WP_016323381.1\|653688_654213_+\|transcription-termination/antitermination-factor-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_KE159709.1\|WP_016323394.1\|665239_665791_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159709.1\|WP_016323392.1\|663979_664555_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159709.1\|WP_040655904.1\|665964_666549_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_KE159709.1\|WP_016323384.1\|655916_656459_+\|50S-ribosomal-protein-L10	unknown	unknown	gnl\|CDD\|234632
NZ_KE159709.1\|WP_016323382.1\|654341_654767_+\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_KE159709.1\|WP_016323383.1\|654861_655554_+\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071

Protein	Function_ID	Function_description	E-value
NZ_KE159709.1\|WP_016323380.1\|653462_653678_+\|preprotein-translocase-subunit-SecE	gnl\|CDD\|376355	pfam00584, SecE, SecE/Sec61-gamma subunits of protein translocation complex. SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.	1.05632e-13
NZ_KE159709.1\|WP_016323390.1\|662248_663484_+\|TniQ-family-protein	gnl\|CDD\|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	1.27949e-21
NZ_KE159709.1\|WP_016323379.1\|653285_653435_+\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	1.98658e-19
NZ_KE159709.1\|WP_155979061.1\|652259_652925_-\|hypothetical-protein	gnl\|CDD\|350617	cd14840, D-Ala-D-Ala_dipeptidase_Aad, D-Ala-D-Ala dipeptidase (includes Lactobacillus plantarum Aad peptidase). D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. This subfamily includes Lactobacillus Aad peptidase and belongs in the MEROPS peptidase family M15, subfamily D.	2.63311e-89
NZ_KE159709.1\|WP_016323385.1\|656504_656873_+\|50S-ribosomal-protein-L7/L12	gnl\|CDD\|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	1.70779e-39
NZ_KE159709.1\|WP_016323393.1\|664644_665226_+\|HD-domain-containing-protein	gnl\|CDD\|366867	pfam01966, HD, HD domain. HD domains are metal dependent phosphohydrolases.	0.000241641
NZ_KE159709.1\|WP_016323377.1\|651826_652252_-\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|335420	pfam03652, RuvX, Holliday junction resolvase. This family of nucleases resolves the Holliday junction intermediates in genetic recombination.	4.28166e-49
NZ_KE159709.1\|WP_040655904.1\|665964_666549_+\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	1.45259e-29
NZ_KE159709.1\|WP_016323387.1\|658802_660563_+\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	4.15562e-10
NZ_KE159709.1\|WP_155979040.1\|658306_658798_+\|hypothetical-protein	gnl\|CDD\|394822	cd21467, Ubl1_cv_Nsp3_N-like, first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins. This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.	0.000734269
NZ_KE159709.1\|WP_016323388.1\|660559_661912_+\|AAA-family-ATPase	gnl\|CDD\|379165	pfam13401, AAA_22, AAA domain.	1.05155e-09
NZ_KE159709.1\|WP_016323381.1\|653688_654213_+\|transcription-termination/antitermination-factor-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	8.82634e-80
NZ_KE159709.1\|WP_016323384.1\|655916_656459_+\|50S-ribosomal-protein-L10	gnl\|CDD\|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	9.2728e-59
NZ_KE159709.1\|WP_016323382.1\|654341_654767_+\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	7.37956e-89
NZ_KE159709.1\|WP_016323383.1\|654861_655554_+\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	1.48903e-140

>NZ_KE159709.1|WP_155979039.1|656960_657158_-|hypothetical-protein
MGVAKSHAVKKKKKDGNQAVSAVTAAFPAKNIKRKGPKQQVVASDLCGWKPYVAAHSFQLQAMYG
>NZ_KE159709.1|WP_016323385.1|656504_656873_+|50S-ribosomal-protein-L7/L12
MSEKVTAMIEEIKGLTVLELSELVHALEEEFGVSAAAMAAPAAAAAPAAEEKTEFDVVLAGFDAAAKIKVIKVVREITGQGLAEAKATVEGAPTTLKEGVSKDDAEALKKQIEEAGGKVELK
>NZ_KE159709.1|WP_016323384.1|655916_656459_+|50S-ribosomal-protein-L10
MPNAKVLSEKQAIVAQLTEKIQKATAGVIVDYKGITVEEDTALRRECRENGVDYAVVKNTLLRFAFNNTGLGDLDDLLNGTTSLALCDDPVVPARVMANYAKKLNDKFEIKGGFMDGKPVDLATINSLASIPALPVLQAQVLGTMLAPITGLAVVLKQIAEKQGAPSEEAAPAEEAPAAE
>NZ_KE159709.1|WP_016323383.1|654861_655554_+|50S-ribosomal-protein-L1
MFRGKKYKESAKQIEKNTQYEAAEGLALVCKTASAKFDETVELHVKLGVDSRHADQQVRGAIVLPHGTGKTVRVLVFAKGDKADAAREAGADYVGEMDLVEKIQKENWFDFDVVVASPDMMGVVGRLGKVLGPKGLMPSPKAGTVTPDVAKAVQEVKAGKIEYRLDKTNIIHCPIGKVSFGPEKLVENYNALMGAIVKAKPAAAKGQYIRSCVAASTMGPGVKMSTAKLV
>NZ_KE159709.1|WP_016323382.1|654341_654767_+|50S-ribosomal-protein-L11
MAQKVTGYIKLQIPAGKATPAPPVGPALGQHGVNIAAFTKEFNERTKNDAGMIIPVVITVYADRSFSFITKTPPAAVLIKKECNIESGSGVPNKTKVATISKASIQKIAEIKMKDLNAASLESAMSMIAGTCRSMGVVVGD
>NZ_KE159709.1|WP_016323381.1|653688_654213_+|transcription-termination/antitermination-factor-NusG
MSDSAKWYVIHTYSGYENAVKTSIEKFVTGRGLEDQILRMEIPLETVTEVTDSGATKEVERKVFPGYVLIKMIMTDETWHLVRNVRGVTGFVGSANKAIPLSEEEVLAMGMEKHEIVVRYSVGDHVRIMDGPLASFTGVVEEIEPEKNRVSVVVSMFGRETPVELELDQVEVQA
>NZ_KE159709.1|WP_016323380.1|653462_653678_+|preprotein-translocase-subunit-SecE
MAEEAKKKKDRGLWFREMKSELKKVVWPNKQTVMKNTGTVLLCSLVIGACIWIFDFVAVSAVDMILSVFGA
>NZ_KE159709.1|WP_016323379.1|653285_653435_+|50S-ribosomal-protein-L33
MRVKVTLRCNECKQRNYNTMKNKKNTPDKLELNKYCRFCRKHTLHSETK
>NZ_KE159709.1|WP_155979061.1|652259_652925_-|hypothetical-protein
MSPPPEEAPAAEEPAPVPEPKPLPAPEPVPEPAPQLEPPPAPADFVLVSDCVPGIRADLKYAGEDNFTGQVIYDFTEAYLRYGTARKLAAAQEILTAQGYSLLIWDAFRPTEAQFRLWEVCPDPVYVANPERGFSSHSRGNTVDVTLVLEDGSPVEMPTGFDDFSPLADRDYSDVPETAAANARLLEDVMTDCGFKPYAGEWWHFSDTDSYPVEEDFVPGK
>NZ_KE159709.1|WP_016323377.1|651826_652252_-|Holliday-junction-resolvase-RuvX
MRIMAIDYGDAHTGIAVSDPTGLLAGFTVTVDAYRPEDAVERIAALAKEHGAEELVLGHPINMDGTLGPRSEKARAMKVLLEERTGLPVVLWDERRTTIDAHWILMNSGKDARKRKKTVDAVAASLILEGYLTYKKSHPRG
>NZ_KE159709.1|WP_155979040.1|658306_658798_+|hypothetical-protein
MKFYDTTCQECPFHQTAGSYTLGTTRYCSGFPGRKPKRFPRSAPKFKPPKWCPRRLSPAVCRVFGFKDEESEWLEFLLRQDNRRRPCPLSSHYSPRMEVPTGLTAKQFYTSVKEECLSQIIPGLDVRPGEVICIDDGLKPYYFYYRSDYEISPLPGFNPTKAR
>NZ_KE159709.1|WP_016323387.1|658802_660563_+|DDE-type-integrase/transposase/recombinase
MNRYVERNGEVFHVLLQEDAGAWLISCQAPAEPFFVAQIEAFNPLEASSLTEALCPHEALSPHEAESLMSPGQVKRLRLIQLLLGDSRCITDKAYRSALAKETAERNGTTSRRILRLYYRYLATGKLMQERQREQSENKVYDWAIRTFYFSAKKLSLRAAYEMMLVQKYTDAKGILLPDAPTWSSFQHYFYAHNYHKRPQKIIARDGLSHYQRNCRPAFGSASRWRESPGSYQMDATQGDLYLVSSLDRSSVVGRPQIYMAVDSATQLIAGIYVGYEAGERAVMACLENAASDKVDFCRKYGIEIQPEQWPSRGLPGEIITDKGREFTGSRMEELCRRYGVELLIQPPFRPDGKGLVEKAFDLLQQRYKPLLRGKGVIESDAQERWAVDYRSQAVLTLEEFTQIVIQCVIYLNSGRVLQSGKTPAQVWLKAMRWLSATGSATGSATGSVTTSATVWKVQDVPSKELHVLSLPREEVKLTRKGFRLHALSYVPQNMDGLYVGDTYTLAYDTLDLSAVFLIGKDRDSRIPLAPDQQQYQGLTQAEAEICREQERQARKQAKAAETQASIQTIQGIQKIVKEAERRRQE
>NZ_KE159709.1|WP_016323388.1|660559_661912_+|AAA-family-ATPase
MNKDFGNPLLAAMPKMLAPQELTQAVQSLPPLPAAPSLEGLALLSSIFIPMDYMYTLYDQLYRAIRTTYTTRTVLEGIRQTNALFRGDAGTCCATQAAAGSVLGVPGIGKTSTIRRCLDTMPQVIEHTDFEGQPFFCKQVLYLRVECPSDCSVKTLALNLVAALDRAIGSNYLHQLTALRSAAASAIAAQVKILCMTHHVGLILVDEIQNAVVTAQKNKQVKPLIKFLVELTNDTCTGVFFVGTPQAEELFTSQEHLKRRTRGIRLLPLKPDGVYRNFLKLLWQYQLTPERAELTEALANKLYDWSGGIPAYIVKIFQESQAQAFLMGRPCIDAKIMQQAINILAIKVPKTYAGGTYLSDFPPIGFQPIQPAEESCKSPADLMAGCKKAGCKPVERKRLYAKKRGRKAAVREEQDLLAAFKAGTDMLEHLARFNLLEKEREDENGDSEDN
>NZ_KE159709.1|WP_016323389.1|661889_662246_+|hypothetical-protein
MEIQKIIEYAKALKPEDMEWKPLYPNNMPGNGLMGYAARLELPDGSGSRYYTIRLQYKEDERGCMLEEVELYVLFERTHSGSDSFVRAFRTLDEAKARAVLQFQMVYGYAMSYLADDM
>NZ_KE159709.1|WP_016323390.1|662248_663484_+|TniQ-family-protein
MLTYFPMPYPGEWWYSVLCRYHVRSGNIKQQTTIRELFPGRITAAISSIFPNSTIRQVIEQLPSDWLLPEAVITQNTLFPYYTRFFLAEKKTALLEKACLGETPTITSLRRSANLSKWRPRYCPQCAEEDRAIYGEAYWHIEHQIPFLKICPNHKCSLYVLEEIQPSHLGYTFYPLEAQVLCLDKCKDIPLWQRTVASILWEYETLPLKPAIAENHNHIAACLSNMGYGVIQNHSPNVILDAKRLYQDMADYYSPEVMEDIFGDVCIINRACKWGTASPERYALLQSFAGVSSETVFSDRPVSDHYADELKVLQCSGTHLTKKQVLEQLSVTPSQLNILLKKYHLEPFWRQMGGECAELGRHRFSFALNDEEFARFKQALRKSGYRYDSHFIRQCVMAYIDANQKEGSGDN
>NZ_KE159709.1|WP_016323391.1|663549_663858_+|hypothetical-protein
MNQYEKAEIVARCVAHLAWQAWLPVREVAACIGPERMEELMNFAQCREFMPIDEMAWEINRGCWLGYELDKDAPLPPEDFGEKTVQRMEDDGLDLYTALVKA
>NZ_KE159709.1|WP_016323392.1|663979_664555_+|hypothetical-protein
MKQKLTAALLDVSLRDSRFCAELLRMLTKGGEAPSGPPQYIGRPPEEPLRSGVRVQTQGKTADISIVENAVPKEDLEDMVLAIPQDVLAVFLCMEGIIGVDEAMTQVQCSGRQGLFLNLKNPESDLLQLLESTRWGTKGTLRLLEKLYAQNDWTQGGGTPQGGRRKQIQTHAASPAGAALERDFSCSLYRL
>NZ_KE159709.1|WP_016323393.1|664644_665226_+|HD-domain-containing-protein
MKARFLDIYHTHITRPGADKLLQWLESTDFFTAPASTRFHLAREGGLLEHSLHVYDRLRKLYQSELAGGARLTPEQEETAAVCGLLHDINKANFYQVEMRNRKNEQGQWEQYPFYVIHDQLPYGHGEKSVYIISGFMRLSREEAMAIRWHMGFSDNDFLGGGYSVGGAFEKFPLAVLTHIADLEAAYLDECRE
>NZ_KE159709.1|WP_016323394.1|665239_665791_+|hypothetical-protein
MTIAEIERGLGAAEFAERFLSRLLGRAVRLPHPPKLAPPDQSIYVCPDAEAAAEDGSAYQIYIGRSRGGPLVKELQIYGGQYEGSRDEIHVILICEGPETPKHWRLEPAIVNTPDGQPVVLDGSRIIYHALFLEPGEGHSLRYRRKQVSFAAFSKAKEAGASDHDALLHAADADSGFLAAFNC
>NZ_KE159709.1|WP_040655904.1|665964_666549_+|recombinase-family-protein
MTHGYARCSTNEDRQDIDRQTRELKKHGAEKVWLEYEHGDAASKEQQALMLETARPGDTIVTLEVSRLARSTKQLCEIIDIIREKRLRLVIVGSITLDCRNGNPDPMTEAFLQIAGVFSQLELSMIRSRVRSGVENARAKGKRLGRPPVCAERVPEHFLRYYPRYQSGSINISELARLARVSRPTAYRYLKALT

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Crispr_ID: NZ_KE159709_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_KE159709_2

657531-657595

Orphan

Consensus_repeat	Method
CAAAAAGCTCAAGCTAATTCTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_KE159709_2

>merge|NZ_KE159709|2|657531-657595|CRISPRCasFinder
CAAAAAGCTCAAGCTAATTCTAAAAGCTGCGGAAATGAAACTCAAAAAACGCGAGGTAAATCAAA

>NZ_KE159709|2|2|657531-657595|CRISPRCasFinder
CAAAAAGCTCAAGCTAATTCTAA	AAGCTGCGGAAATGAAACT
CAAAAAACGCGAGGTAAATCAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_KE159709.1\|WP_016323380.1\|653462_653678_+\|preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|376355
NZ_KE159709.1\|WP_016323390.1\|662248_663484_+\|TniQ-family-protein	unknown	unknown	gnl\|CDD\|377670
NZ_KE159709.1\|WP_016323379.1\|653285_653435_+\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
NZ_KE159709.1\|WP_155979061.1\|652259_652925_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350617
NZ_KE159709.1\|WP_016323385.1\|656504_656873_+\|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl\|CDD\|234671
NZ_KE159709.1\|WP_016323377.1\|651826_652252_-\|Holliday-junction-resolvase-RuvX	unknown	unknown	gnl\|CDD\|335420
NZ_KE159709.1\|WP_016323393.1\|664644_665226_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|366867
NZ_KE159709.1\|WP_155979039.1\|656960_657158_-\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159709.1\|WP_016323389.1\|661889_662246_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159709.1\|WP_016323387.1\|658802_660563_+\|DDE-type-integrase/transposase/recombinase	unknown	unknown	gnl\|CDD\|366234
NZ_KE159709.1\|WP_155979040.1\|658306_658798_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|394822
NZ_KE159709.1\|WP_016323388.1\|660559_661912_+\|AAA-family-ATPase	unknown	unknown	gnl\|CDD\|379165
NZ_KE159709.1\|WP_016323391.1\|663549_663858_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159709.1\|WP_016323381.1\|653688_654213_+\|transcription-termination/antitermination-factor-NusG	unknown	unknown	gnl\|CDD\|180161
NZ_KE159709.1\|WP_016323394.1\|665239_665791_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159709.1\|WP_016323392.1\|663979_664555_+\|hypothetical-protein	unknown	unknown	unknown
NZ_KE159709.1\|WP_040655904.1\|665964_666549_+\|recombinase-family-protein	unknown	unknown	gnl\|CDD\|239737
NZ_KE159709.1\|WP_016323384.1\|655916_656459_+\|50S-ribosomal-protein-L10	unknown	unknown	gnl\|CDD\|234632
NZ_KE159709.1\|WP_016323382.1\|654341_654767_+\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
NZ_KE159709.1\|WP_016323383.1\|654861_655554_+\|50S-ribosomal-protein-L1	unknown	unknown	gnl\|CDD\|180071

Protein	Function_ID	Function_description	E-value
NZ_KE159709.1\|WP_016323380.1\|653462_653678_+\|preprotein-translocase-subunit-SecE	gnl\|CDD\|376355	pfam00584, SecE, SecE/Sec61-gamma subunits of protein translocation complex. SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.	1.05632e-13
NZ_KE159709.1\|WP_016323390.1\|662248_663484_+\|TniQ-family-protein	gnl\|CDD\|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	1.27949e-21
NZ_KE159709.1\|WP_016323379.1\|653285_653435_+\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	1.98658e-19
NZ_KE159709.1\|WP_155979061.1\|652259_652925_-\|hypothetical-protein	gnl\|CDD\|350617	cd14840, D-Ala-D-Ala_dipeptidase_Aad, D-Ala-D-Ala dipeptidase (includes Lactobacillus plantarum Aad peptidase). D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. This subfamily includes Lactobacillus Aad peptidase and belongs in the MEROPS peptidase family M15, subfamily D.	2.63311e-89
NZ_KE159709.1\|WP_016323385.1\|656504_656873_+\|50S-ribosomal-protein-L7/L12	gnl\|CDD\|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	1.70779e-39
NZ_KE159709.1\|WP_016323393.1\|664644_665226_+\|HD-domain-containing-protein	gnl\|CDD\|366867	pfam01966, HD, HD domain. HD domains are metal dependent phosphohydrolases.	0.000241641
NZ_KE159709.1\|WP_016323377.1\|651826_652252_-\|Holliday-junction-resolvase-RuvX	gnl\|CDD\|335420	pfam03652, RuvX, Holliday junction resolvase. This family of nucleases resolves the Holliday junction intermediates in genetic recombination.	4.28166e-49
NZ_KE159709.1\|WP_040655904.1\|665964_666549_+\|recombinase-family-protein	gnl\|CDD\|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	1.45259e-29
NZ_KE159709.1\|WP_016323387.1\|658802_660563_+\|DDE-type-integrase/transposase/recombinase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	4.15562e-10
NZ_KE159709.1\|WP_155979040.1\|658306_658798_+\|hypothetical-protein	gnl\|CDD\|394822	cd21467, Ubl1_cv_Nsp3_N-like, first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins. This ubiquitin-like (Ubl) domain (Ubl1) is found at the N-terminus of coronavirus Nsp3, a large multi-functional multi-domain protein which is an essential component of the replication/transcription complex (RTC). The functions of Ubl1 in CoVs are related to single-stranded RNA (ssRNA) binding and to interacting with the nucleocapsid (N) protein. SARS-CoV Ubl1 has been shown to bind ssRNA having AUA patterns, and since the 5'-UTR of the SARS-CoV genome has a number of AUA repeats, it may bind there. In mouse hepatitis virus (MHV), this Ubl1 domain binds the cognate N protein. Adjacent to Ubl1 is a Glu-rich acidic region (also referred to as hypervariable region, HVR); Ubl1 together with HVR has been called Nsp3a. Currently, the function of HVR in CoVs is unknown. This model corresponds to one of two Ubl domains in Nsp3; the other is located N-terminal to the papain-like protease (PLpro) and is not represented by this model.	0.000734269
NZ_KE159709.1\|WP_016323388.1\|660559_661912_+\|AAA-family-ATPase	gnl\|CDD\|379165	pfam13401, AAA_22, AAA domain.	1.05155e-09
NZ_KE159709.1\|WP_016323381.1\|653688_654213_+\|transcription-termination/antitermination-factor-NusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	8.82634e-80
NZ_KE159709.1\|WP_016323384.1\|655916_656459_+\|50S-ribosomal-protein-L10	gnl\|CDD\|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	9.2728e-59
NZ_KE159709.1\|WP_016323382.1\|654341_654767_+\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	7.37956e-89
NZ_KE159709.1\|WP_016323383.1\|654861_655554_+\|50S-ribosomal-protein-L1	gnl\|CDD\|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	1.48903e-140

>NZ_KE159709.1|WP_155979039.1|656960_657158_-|hypothetical-protein
MGVAKSHAVKKKKKDGNQAVSAVTAAFPAKNIKRKGPKQQVVASDLCGWKPYVAAHSFQLQAMYG
>NZ_KE159709.1|WP_016323385.1|656504_656873_+|50S-ribosomal-protein-L7/L12
MSEKVTAMIEEIKGLTVLELSELVHALEEEFGVSAAAMAAPAAAAAPAAEEKTEFDVVLAGFDAAAKIKVIKVVREITGQGLAEAKATVEGAPTTLKEGVSKDDAEALKKQIEEAGGKVELK
>NZ_KE159709.1|WP_016323384.1|655916_656459_+|50S-ribosomal-protein-L10
MPNAKVLSEKQAIVAQLTEKIQKATAGVIVDYKGITVEEDTALRRECRENGVDYAVVKNTLLRFAFNNTGLGDLDDLLNGTTSLALCDDPVVPARVMANYAKKLNDKFEIKGGFMDGKPVDLATINSLASIPALPVLQAQVLGTMLAPITGLAVVLKQIAEKQGAPSEEAAPAEEAPAAE
>NZ_KE159709.1|WP_016323383.1|654861_655554_+|50S-ribosomal-protein-L1
MFRGKKYKESAKQIEKNTQYEAAEGLALVCKTASAKFDETVELHVKLGVDSRHADQQVRGAIVLPHGTGKTVRVLVFAKGDKADAAREAGADYVGEMDLVEKIQKENWFDFDVVVASPDMMGVVGRLGKVLGPKGLMPSPKAGTVTPDVAKAVQEVKAGKIEYRLDKTNIIHCPIGKVSFGPEKLVENYNALMGAIVKAKPAAAKGQYIRSCVAASTMGPGVKMSTAKLV
>NZ_KE159709.1|WP_016323382.1|654341_654767_+|50S-ribosomal-protein-L11
MAQKVTGYIKLQIPAGKATPAPPVGPALGQHGVNIAAFTKEFNERTKNDAGMIIPVVITVYADRSFSFITKTPPAAVLIKKECNIESGSGVPNKTKVATISKASIQKIAEIKMKDLNAASLESAMSMIAGTCRSMGVVVGD
>NZ_KE159709.1|WP_016323381.1|653688_654213_+|transcription-termination/antitermination-factor-NusG
MSDSAKWYVIHTYSGYENAVKTSIEKFVTGRGLEDQILRMEIPLETVTEVTDSGATKEVERKVFPGYVLIKMIMTDETWHLVRNVRGVTGFVGSANKAIPLSEEEVLAMGMEKHEIVVRYSVGDHVRIMDGPLASFTGVVEEIEPEKNRVSVVVSMFGRETPVELELDQVEVQA
>NZ_KE159709.1|WP_016323380.1|653462_653678_+|preprotein-translocase-subunit-SecE
MAEEAKKKKDRGLWFREMKSELKKVVWPNKQTVMKNTGTVLLCSLVIGACIWIFDFVAVSAVDMILSVFGA
>NZ_KE159709.1|WP_016323379.1|653285_653435_+|50S-ribosomal-protein-L33
MRVKVTLRCNECKQRNYNTMKNKKNTPDKLELNKYCRFCRKHTLHSETK
>NZ_KE159709.1|WP_155979061.1|652259_652925_-|hypothetical-protein
MSPPPEEAPAAEEPAPVPEPKPLPAPEPVPEPAPQLEPPPAPADFVLVSDCVPGIRADLKYAGEDNFTGQVIYDFTEAYLRYGTARKLAAAQEILTAQGYSLLIWDAFRPTEAQFRLWEVCPDPVYVANPERGFSSHSRGNTVDVTLVLEDGSPVEMPTGFDDFSPLADRDYSDVPETAAANARLLEDVMTDCGFKPYAGEWWHFSDTDSYPVEEDFVPGK
>NZ_KE159709.1|WP_016323377.1|651826_652252_-|Holliday-junction-resolvase-RuvX
MRIMAIDYGDAHTGIAVSDPTGLLAGFTVTVDAYRPEDAVERIAALAKEHGAEELVLGHPINMDGTLGPRSEKARAMKVLLEERTGLPVVLWDERRTTIDAHWILMNSGKDARKRKKTVDAVAASLILEGYLTYKKSHPRG
>NZ_KE159709.1|WP_155979040.1|658306_658798_+|hypothetical-protein
MKFYDTTCQECPFHQTAGSYTLGTTRYCSGFPGRKPKRFPRSAPKFKPPKWCPRRLSPAVCRVFGFKDEESEWLEFLLRQDNRRRPCPLSSHYSPRMEVPTGLTAKQFYTSVKEECLSQIIPGLDVRPGEVICIDDGLKPYYFYYRSDYEISPLPGFNPTKAR
>NZ_KE159709.1|WP_016323387.1|658802_660563_+|DDE-type-integrase/transposase/recombinase
MNRYVERNGEVFHVLLQEDAGAWLISCQAPAEPFFVAQIEAFNPLEASSLTEALCPHEALSPHEAESLMSPGQVKRLRLIQLLLGDSRCITDKAYRSALAKETAERNGTTSRRILRLYYRYLATGKLMQERQREQSENKVYDWAIRTFYFSAKKLSLRAAYEMMLVQKYTDAKGILLPDAPTWSSFQHYFYAHNYHKRPQKIIARDGLSHYQRNCRPAFGSASRWRESPGSYQMDATQGDLYLVSSLDRSSVVGRPQIYMAVDSATQLIAGIYVGYEAGERAVMACLENAASDKVDFCRKYGIEIQPEQWPSRGLPGEIITDKGREFTGSRMEELCRRYGVELLIQPPFRPDGKGLVEKAFDLLQQRYKPLLRGKGVIESDAQERWAVDYRSQAVLTLEEFTQIVIQCVIYLNSGRVLQSGKTPAQVWLKAMRWLSATGSATGSATGSVTTSATVWKVQDVPSKELHVLSLPREEVKLTRKGFRLHALSYVPQNMDGLYVGDTYTLAYDTLDLSAVFLIGKDRDSRIPLAPDQQQYQGLTQAEAEICREQERQARKQAKAAETQASIQTIQGIQKIVKEAERRRQE
>NZ_KE159709.1|WP_016323388.1|660559_661912_+|AAA-family-ATPase
MNKDFGNPLLAAMPKMLAPQELTQAVQSLPPLPAAPSLEGLALLSSIFIPMDYMYTLYDQLYRAIRTTYTTRTVLEGIRQTNALFRGDAGTCCATQAAAGSVLGVPGIGKTSTIRRCLDTMPQVIEHTDFEGQPFFCKQVLYLRVECPSDCSVKTLALNLVAALDRAIGSNYLHQLTALRSAAASAIAAQVKILCMTHHVGLILVDEIQNAVVTAQKNKQVKPLIKFLVELTNDTCTGVFFVGTPQAEELFTSQEHLKRRTRGIRLLPLKPDGVYRNFLKLLWQYQLTPERAELTEALANKLYDWSGGIPAYIVKIFQESQAQAFLMGRPCIDAKIMQQAINILAIKVPKTYAGGTYLSDFPPIGFQPIQPAEESCKSPADLMAGCKKAGCKPVERKRLYAKKRGRKAAVREEQDLLAAFKAGTDMLEHLARFNLLEKEREDENGDSEDN
>NZ_KE159709.1|WP_016323389.1|661889_662246_+|hypothetical-protein
MEIQKIIEYAKALKPEDMEWKPLYPNNMPGNGLMGYAARLELPDGSGSRYYTIRLQYKEDERGCMLEEVELYVLFERTHSGSDSFVRAFRTLDEAKARAVLQFQMVYGYAMSYLADDM
>NZ_KE159709.1|WP_016323390.1|662248_663484_+|TniQ-family-protein
MLTYFPMPYPGEWWYSVLCRYHVRSGNIKQQTTIRELFPGRITAAISSIFPNSTIRQVIEQLPSDWLLPEAVITQNTLFPYYTRFFLAEKKTALLEKACLGETPTITSLRRSANLSKWRPRYCPQCAEEDRAIYGEAYWHIEHQIPFLKICPNHKCSLYVLEEIQPSHLGYTFYPLEAQVLCLDKCKDIPLWQRTVASILWEYETLPLKPAIAENHNHIAACLSNMGYGVIQNHSPNVILDAKRLYQDMADYYSPEVMEDIFGDVCIINRACKWGTASPERYALLQSFAGVSSETVFSDRPVSDHYADELKVLQCSGTHLTKKQVLEQLSVTPSQLNILLKKYHLEPFWRQMGGECAELGRHRFSFALNDEEFARFKQALRKSGYRYDSHFIRQCVMAYIDANQKEGSGDN
>NZ_KE159709.1|WP_016323391.1|663549_663858_+|hypothetical-protein
MNQYEKAEIVARCVAHLAWQAWLPVREVAACIGPERMEELMNFAQCREFMPIDEMAWEINRGCWLGYELDKDAPLPPEDFGEKTVQRMEDDGLDLYTALVKA
>NZ_KE159709.1|WP_016323392.1|663979_664555_+|hypothetical-protein
MKQKLTAALLDVSLRDSRFCAELLRMLTKGGEAPSGPPQYIGRPPEEPLRSGVRVQTQGKTADISIVENAVPKEDLEDMVLAIPQDVLAVFLCMEGIIGVDEAMTQVQCSGRQGLFLNLKNPESDLLQLLESTRWGTKGTLRLLEKLYAQNDWTQGGGTPQGGRRKQIQTHAASPAGAALERDFSCSLYRL
>NZ_KE159709.1|WP_016323393.1|664644_665226_+|HD-domain-containing-protein
MKARFLDIYHTHITRPGADKLLQWLESTDFFTAPASTRFHLAREGGLLEHSLHVYDRLRKLYQSELAGGARLTPEQEETAAVCGLLHDINKANFYQVEMRNRKNEQGQWEQYPFYVIHDQLPYGHGEKSVYIISGFMRLSREEAMAIRWHMGFSDNDFLGGGYSVGGAFEKFPLAVLTHIADLEAAYLDECRE
>NZ_KE159709.1|WP_016323394.1|665239_665791_+|hypothetical-protein
MTIAEIERGLGAAEFAERFLSRLLGRAVRLPHPPKLAPPDQSIYVCPDAEAAAEDGSAYQIYIGRSRGGPLVKELQIYGGQYEGSRDEIHVILICEGPETPKHWRLEPAIVNTPDGQPVVLDGSRIIYHALFLEPGEGHSLRYRRKQVSFAAFSKAKEAGASDHDALLHAADADSGFLAAFNC
>NZ_KE159709.1|WP_040655904.1|665964_666549_+|recombinase-family-protein
MTHGYARCSTNEDRQDIDRQTRELKKHGAEKVWLEYEHGDAASKEQQALMLETARPGDTIVTLEVSRLARSTKQLCEIIDIIREKRLRLVIVGSITLDCRNGNPDPMTEAFLQIAGVFSQLELSMIRSRVRSGVENARAKGKRLGRPPVCAERVPEHFLRYYPRYQSGSINISELARLARVSRPTAYRYLKALT

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_KE159709_1	1.1\|657379\|16\|NZ_KE159709\|CRISPRCasFinder	657379-657394	16	NZ_KE159712.1	6687-6702	0	1.0

1. spacer 1.1|657379|16|NZ_KE159709|CRISPRCasFinder matches to position: 6687-6702, mismatch: 0, identity: 1.0

ttaacatgagcttttt	CRISPR spacer
ttaacatgagcttttt	Protospacer
****************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

202782 : 212734

Streptococcus_phage(33.33%)

integrase

attL 194527:194542|attR 208764:208779

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
194527:194542	attL	NA	NA	NA	NA
WP_016322970.1\|202782_203847_+	AAA family ATPase	A0A2P1CFH0	Microbacterium_phage	3.8e-08	27.3
WP_016322971.1\|204107_204422_+	hypothetical protein	NA	NA	NA	NA
WP_016322972.1\|204421_205426_+	relaxase/mobilization nuclease domain-containing protein	A0A1B0RXG0	Streptococcus_phage	8.6e-10	48.4
WP_016322973.1\|205439_206618_+\|integrase	site-specific integrase	A0A2I7SC08	Paenibacillus_phage	7.2e-16	21.8
WP_016322974.1\|206743_207919_+\|integrase	site-specific integrase	S5MNZ2	Brevibacillus_phage	1.2e-34	28.9
WP_016322975.1\|207971_208340_-	hypothetical protein	NA	NA	NA	NA
WP_016322976.1\|208379_208916_-	rubrerythrin family protein	NA	NA	NA	NA
208764:208779	attR	NA	NA	NA	NA
WP_016322977.1\|209247_210414_-	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	2.6e-90	43.6
WP_016322978.1\|210913_212734_+	translational GTPase TypA	A0A2K5B2A5	Erysipelothrix_phage	1.0e-21	41.9

DBSCAN-SWA_2

282863 : 405050

119

Faecalibacterium_phage(17.65%)

plate,integrase,transposase,tail

attL 294636:294652|attR 401289:401305

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_081646360.1\|282863_283490_+\|transposase	IS630 family transposase	NA	NA	NA	NA
WP_016323043.1\|284525_284900_+	BlaI/MecI/CopY family transcriptional regulator	NA	NA	NA	NA
WP_016323044.1\|284896_286873_+	peptidoglycan DD-metalloendopeptidase family protein	A0A075BS18	Microcystis_phage	9.3e-16	52.3
WP_016323045.1\|287018_287312_+	DUF2089 family protein	NA	NA	NA	NA
WP_016323046.1\|287312_287693_+	hypothetical protein	NA	NA	NA	NA
WP_016323047.1\|287706_288042_+	hypothetical protein	NA	NA	NA	NA
WP_016323048.1\|288075_288705_-	hypothetical protein	NA	NA	NA	NA
WP_016323049.1\|288712_289600_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_040655655.1\|289648_290242_+	hypothetical protein	NA	NA	NA	NA
WP_016323050.1\|290293_291307_+	AbrB family transcriptional regulator	NA	NA	NA	NA
WP_081646361.1\|291290_292391_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_016323052.1\|292391_292688_+	citrate lyase acyl carrier protein	NA	NA	NA	NA
WP_040655812.1\|292726_293587_+	citrate lyase subunit beta	NA	NA	NA	NA
WP_016323054.1\|293590_295120_+	citrate lyase subunit alpha	NA	NA	NA	NA
294636:294652	attL	NA	NA	NA	NA
WP_016323055.1\|295153_296404_+	citrate lyase holo-[acyl-carrier protein] synthase	NA	NA	NA	NA
WP_155979021.1\|296587_297994_-	MATE family efflux transporter	NA	NA	NA	NA
WP_051147093.1\|298095_299097_-	LysR family transcriptional regulator	NA	NA	NA	NA
WP_016323058.1\|299325_300951_+	amidohydrolase	NA	NA	NA	NA
WP_016323059.1\|301030_302596_+	AbgT family transporter	NA	NA	NA	NA
WP_016323060.1\|302701_303799_+	hypothetical protein	NA	NA	NA	NA
WP_016323061.1\|304307_305081_+	YmdB family metallophosphoesterase	NA	NA	NA	NA
WP_016323062.1\|305121_305595_+	YbaK/EbsC family protein	NA	NA	NA	NA
WP_016323063.1\|305623_306721_+	DNA repair exonuclease	NA	NA	NA	NA
WP_016323064.1\|306726_307719_+	asparaginase	NA	NA	NA	NA
WP_016323065.1\|307805_310964_-	PAS domain-containing hybrid sensor histidine kinase/response regulator	A0A1V0SGX0	Hokovirus	1.2e-49	28.7
WP_155979022.1\|311121_312216_+	hypothetical protein	NA	NA	NA	NA
WP_016323067.1\|312245_313481_+	glycerate kinase	NA	NA	NA	NA
WP_016323068.1\|313544_314192_+	hypothetical protein	NA	NA	NA	NA
WP_016323069.1\|314569_314782_-	hypothetical protein	NA	NA	NA	NA
WP_016323070.1\|314867_315941_-	S-layer homology domain-containing protein	NA	NA	NA	NA
WP_016323071.1\|315950_316580_-	redox-sensing transcriptional repressor Rex	NA	NA	NA	NA
WP_155979023.1\|316830_317574_-	hypothetical protein	NA	NA	NA	NA
WP_016323073.1\|317723_318938_-	hypothetical protein	NA	NA	NA	NA
WP_016323074.1\|319241_320585_+	putative aminohydrolase SsnA	NA	NA	NA	NA
WP_016323075.1\|320612_323561_+	putative selenate reductase subunit YgfK	NA	NA	NA	NA
WP_040655662.1\|323838_324426_+	hypothetical protein	NA	NA	NA	NA
WP_155979024.1\|324448_324742_+	hypothetical protein	NA	NA	NA	NA
WP_016323077.1\|324769_325186_+	ribonuclease III family protein	NA	NA	NA	NA
WP_016323078.1\|325176_326916_+	fibronectin/fibrinogen-binding protein	M1I5P2	Paramecium_bursaria_Chlorella_virus	1.3e-08	36.3
WP_016323080.1\|327454_327676_-	DUF378 domain-containing protein	NA	NA	NA	NA
WP_040655665.1\|327960_328167_+	hypothetical protein	NA	NA	NA	NA
WP_016323081.1\|328212_328485_+	hypothetical protein	NA	NA	NA	NA
WP_081646363.1\|328583_329435_+\|integrase,transposase	DDE-type integrase/transposase/recombinase	A0A059NT83	Lactococcus_phage	1.3e-22	32.3
WP_016323086.1\|331608_332322_-\|transposase	ISAs1 family transposase	NA	NA	NA	NA
WP_016323087.1\|332765_333962_-\|integrase	site-specific integrase	A0A1S5SEW7	Streptococcus_phage	7.1e-152	67.8
WP_016323088.1\|334051_334255_-	excisionase family DNA-binding domain-containing protein	A0A1S5SF07	Streptococcus_phage	4.2e-25	80.6
WP_016323089.1\|334690_334942_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
WP_016323090.1\|334922_335366_-	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
WP_016323091.1\|335767_337093_-	MATE family efflux transporter	NA	NA	NA	NA
WP_016323092.1\|337180_337795_-	isoprenylcysteine carboxylmethyltransferase family protein	NA	NA	NA	NA
WP_016323093.1\|337871_338432_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
WP_016323094.1\|338506_339115_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_016323095.1\|339279_339636_+	helix-turn-helix transcriptional regulator	A0A1S5SFA6	Streptococcus_phage	1.9e-20	45.5
WP_016220880.1\|339879_340209_+	plasmid mobilization relaxosome protein MobC	NA	NA	NA	NA
WP_016320839.1\|340353_341151_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	7.0e-55	47.5
WP_040654539.1\|341143_342367_-\|transposase	IS21 family transposase	A0A059NT83	Lactococcus_phage	5.9e-45	33.4
WP_155979047.1\|343261_346444_+\|tail	phage tail tape measure protein	A0A1J0MFP9	Staphylococcus_phage	1.5e-84	52.7
WP_016323098.1\|346436_346646_+	hypothetical protein	A0A2K9V482	Faecalibacterium_phage	5.9e-14	52.4
WP_016323099.1\|346642_347680_+	hypothetical protein	A0A2K9V458	Faecalibacterium_phage	1.5e-65	35.9
WP_016323100.1\|348022_348424_+\|tail	phage tail protein	NA	NA	NA	NA
WP_016323101.1\|348439_348757_+	hypothetical protein	A0A2K9V479	Faecalibacterium_phage	4.0e-14	44.1
WP_016323102.1\|348746_349874_+\|plate	baseplate J/gp47 family protein	A0A0C5AEG2	Bacteriophage	2.1e-81	43.7
WP_081646364.1\|349833_350787_+\|tail	phage tail protein I	A0A2K9V471	Faecalibacterium_phage	1.3e-36	47.0
WP_016323104.1\|350790_351669_+\|tail	phage tail protein	A0A090DCR2	Clostridium_phage	1.3e-22	36.2
WP_016323105.1\|351662_351935_+	hypothetical protein	A0A2K9VH74	Faecalibacterium_phage	2.0e-09	34.8
WP_016323106.1\|351889_352318_+	four helix bundle protein	NA	NA	NA	NA
WP_155979048.1\|352695_353805_+	reverse transcriptase	H7BWD2	unidentified_phage	2.3e-120	60.2
WP_016323108.1\|353804_355523_+	hypothetical protein	H7BW54	unidentified_phage	8.3e-170	56.4
WP_016323109.1\|355519_356008_+	hypothetical protein	NA	NA	NA	NA
WP_016323110.1\|356004_356481_+	hypothetical protein	NA	NA	NA	NA
WP_016323111.1\|356487_356796_+	hypothetical protein	D2XR31	Bacillus_phage	5.1e-06	31.4
WP_016323112.1\|356813_357212_+	hypothetical protein	NA	NA	NA	NA
WP_155979049.1\|357285_358857_+	hypothetical protein	Q938J4	Temperate_phage	6.9e-30	56.8
WP_016323114.1\|358871_359294_+	hypothetical protein	NA	NA	NA	NA
WP_016323116.1\|359948_360248_-	hypothetical protein	NA	NA	NA	NA
WP_016323117.1\|360465_360912_-	hypothetical protein	NA	NA	NA	NA
WP_016323118.1\|360973_361549_-	hypothetical protein	NA	NA	NA	NA
WP_016323120.1\|362048_362333_+	hypothetical protein	NA	NA	NA	NA
WP_016323121.1\|362379_363090_-	hypothetical protein	NA	NA	NA	NA
WP_016323122.1\|363256_363499_+	helix-turn-helix transcriptional regulator	A0A2K9V2T3	Faecalibacterium_phage	1.5e-08	45.7
WP_016323123.1\|363614_364658_+\|transposase	IS30 family transposase	H7BWC8	unidentified_phage	1.6e-104	58.8
WP_016323124.1\|365107_366469_-	MATE family efflux transporter	NA	NA	NA	NA
WP_016323125.1\|366513_366939_-	YjbQ family protein	NA	NA	NA	NA
WP_016323126.1\|366952_367798_-	amidohydrolase family protein	NA	NA	NA	NA
WP_016323127.1\|367813_368629_-	fructoselysine 3-epimerase	NA	NA	NA	NA
WP_016323128.1\|368884_369880_+	SIS domain-containing protein	NA	NA	NA	NA
WP_081646365.1\|369995_370799_+	histidinol-phosphatase HisJ family protein	NA	NA	NA	NA
WP_016323130.1\|370829_371930_-	SIS domain-containing protein	NA	NA	NA	NA
WP_016323131.1\|371943_373596_-	iron ABC transporter permease	NA	NA	NA	NA
WP_016323132.1\|373601_374672_-	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	6.8e-29	36.1
WP_081646366.1\|374748_375918_-	extracellular solute-binding protein	NA	NA	NA	NA
WP_016323134.1\|376061_376841_-	response regulator	NA	NA	NA	NA
WP_016323135.1\|376837_378514_-	two-component sensor histidine kinase	Q9EYF3	Enterobacteria_phage	7.1e-17	30.0
WP_040655676.1\|378624_379449_+	BtpA/SgcQ family protein	NA	NA	NA	NA
WP_016323137.1\|379445_380234_+	HAD hydrolase family protein	NA	NA	NA	NA
WP_016323138.1\|380624_381395_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_155979025.1\|381381_382158_+	UTRA domain-containing protein	NA	NA	NA	NA
WP_016323140.1\|382240_383092_+	hypothetical protein	NA	NA	NA	NA
WP_081646367.1\|383193_384573_+	MATE family efflux transporter	NA	NA	NA	NA
WP_016323142.1\|384575_385310_+	GntR family transcriptional regulator	NA	NA	NA	NA
WP_016323143.1\|385316_386219_+	hypothetical protein	NA	NA	NA	NA
WP_016323144.1\|386248_387154_+	transporter substrate-binding domain-containing protein	NA	NA	NA	NA
WP_155979050.1\|387250_387937_+	ABC transporter permease subunit	NA	NA	NA	NA
WP_040655828.1\|387978_388716_+	amino acid ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.5e-30	39.1
WP_016323147.1\|388728_389736_+	SIS domain-containing protein	NA	NA	NA	NA
WP_155979026.1\|389757_390732_+	phosphosugar isomerase	NA	NA	NA	NA
WP_016323150.1\|390988_391405_-	magnesium transporter	NA	NA	NA	NA
WP_016323151.1\|391823_392066_-\|transposase	transposase	NA	NA	NA	NA
WP_081646368.1\|392114_393020_-\|transposase	IS110 family transposase	A0A0U3ULR1	Bacillus_phage	4.3e-16	25.0
WP_016323153.1\|393500_393923_+	hypothetical protein	NA	NA	NA	NA
WP_155979051.1\|394195_395848_+	restriction endonuclease	NA	NA	NA	NA
WP_016323155.1\|395989_397135_+\|integrase	site-specific integrase	A0A1B0T6A8	Bacillus_phage	4.1e-40	31.2
WP_016323156.1\|397289_398384_-	virulence RhuM family protein	Q9JMN3	Wolbachia_phage	4.4e-84	50.2
WP_155979027.1\|398474_399341_-	DUF1016 family protein	Q9JMP5	Wolbachia_phage	1.6e-07	34.9
WP_016323158.1\|399466_400216_-	hypothetical protein	S5WCV6	Mycobacterium_phage	4.9e-10	29.6
WP_016323159.1\|400229_401858_-	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	5.2e-97	45.1
401289:401305	attR	NA	NA	NA	NA
WP_016323160.1\|401854_402709_-	hypothetical protein	NA	NA	NA	NA
WP_016323161.1\|402708_404298_-	recombinase family protein	A0A2K5B2B2	Erysipelothrix_phage	6.6e-81	36.1
WP_016323163.1\|404675_405050_-	type II toxin-antitoxin system PemK/MazF family toxin	A0A2P0ZKX3	Lactobacillus_phage	1.7e-11	37.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

7. NZ_KE159710

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

358302 : 415369

Staphylococcus_virus(10.53%)

integrase,transposase

attL 390423:390438|attR 425428:425443

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016323761.1\|358302_359502_+\|integrase	site-specific integrase	A0A1S5SEW7	Streptococcus_phage	5.3e-107	48.4
WP_016323762.1\|359663_360140_+	low molecular weight phosphotyrosine protein phosphatase	NA	NA	NA	NA
WP_016323763.1\|360146_360707_+	KilA-N domain-containing protein	Q4ZC41	Staphylococcus_virus	1.7e-39	48.6
WP_081646403.1\|360607_361012_+	KilA-N domain-containing protein	Q4ZC41	Staphylococcus_virus	4.5e-26	43.9
WP_016323765.1\|361100_362414_+	hypothetical protein	NA	NA	NA	NA
WP_155979076.1\|362419_362671_+	hypothetical protein	NA	NA	NA	NA
WP_155979077.1\|362751_363663_+	hypothetical protein	NA	NA	NA	NA
WP_016323767.1\|363690_364842_+	hypothetical protein	NA	NA	NA	NA
WP_040656116.1\|364910_365507_+	peptidylprolyl isomerase	A0A1B1IVS0	uncultured_Mediterranean_phage	3.9e-18	42.0
WP_016320743.1\|366529_368062_-\|transposase	IS3 family transposase	A0A0C5AC89	Paenibacillus_phage	3.0e-62	53.7
WP_016323772.1\|369803_370433_-	DUF3267 domain-containing protein	NA	NA	NA	NA
WP_016323773.1\|370459_372838_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_016323774.1\|372852_373518_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.7e-34	39.8
WP_016323776.1\|373887_374553_-	chloramphenicol O-acetyltransferase	NA	NA	NA	NA
WP_016323777.1\|374629_375049_-	hypothetical protein	NA	NA	NA	NA
WP_016323778.1\|375075_376107_-	HAMP domain-containing histidine kinase	A0A2K9L0Z8	Tupanvirus	2.3e-13	24.7
WP_016323779.1\|376103_376796_-	response regulator transcription factor	Q6XM27	Feldmannia_irregularis_virus	2.0e-05	26.8
WP_081646405.1\|378094_379768_+	PucR family transcriptional regulator	NA	NA	NA	NA
WP_155979078.1\|379760_379919_+	hypothetical protein	NA	NA	NA	NA
WP_016323783.1\|380735_381404_+	response regulator transcription factor	NA	NA	NA	NA
WP_016323784.1\|381400_382411_+	sensor histidine kinase	Q8QKV4	Ectocarpus_siliculosus_virus	1.4e-07	31.4
WP_016323785.1\|382489_383248_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.3e-31	34.6
WP_155979079.1\|383234_385187_+	FtsX-like permease family protein	NA	NA	NA	NA
WP_155979080.1\|385528_385729_+	hypothetical protein	NA	NA	NA	NA
WP_016320743.1\|385743_387276_-\|transposase	IS3 family transposase	A0A0C5AC89	Paenibacillus_phage	3.0e-62	53.7
WP_016323787.1\|387409_388624_+	hypothetical protein	NA	NA	NA	NA
WP_016323788.1\|388617_389742_+	hypothetical protein	NA	NA	NA	NA
WP_155979095.1\|389843_390812_+	hypothetical protein	NA	NA	NA	NA
390423:390438	attL	NA	NA	NA	NA
WP_155979081.1\|390808_391477_+	DUF4240 domain-containing protein	NA	NA	NA	NA
WP_016323791.1\|391477_392752_+	DUF4314 domain-containing protein	A0A1V0EEZ8	Caulobacter_phage	5.8e-11	43.0
WP_016323792.1\|392744_393956_+	hypothetical protein	NA	NA	NA	NA
WP_016323793.1\|394008_395394_+	hypothetical protein	NA	NA	NA	NA
WP_016323794.1\|395556_395910_+	hypothetical protein	NA	NA	NA	NA
WP_016323795.1\|395902_396883_+	DNA adenine methylase	A0A2H4IYF4	uncultured_Caudovirales_phage	4.4e-27	31.9
WP_016323796.1\|396898_397408_+	hypothetical protein	NA	NA	NA	NA
WP_016323797.1\|397397_398141_+	DUF3849 domain-containing protein	NA	NA	NA	NA
WP_016323798.1\|398155_398509_+	hypothetical protein	NA	NA	NA	NA
WP_016323799.1\|398554_398743_+	hypothetical protein	NA	NA	NA	NA
WP_016323800.1\|398756_399674_+	hypothetical protein	NA	NA	NA	NA
WP_016323801.1\|399712_400561_+	class D sortase	NA	NA	NA	NA
WP_016323802.1\|400681_401674_+	hypothetical protein	NA	NA	NA	NA
WP_016323804.1\|404936_406304_-	recombinase family protein	D2IZV7	Enterococcus_phage	2.0e-65	36.4
WP_016323805.1\|406453_407035_-	Uma2 family endonuclease	NA	NA	NA	NA
WP_081646414.1\|407089_407632_-	helix-turn-helix transcriptional regulator	A0A2K9V305	Faecalibacterium_phage	6.3e-15	38.4
WP_040656005.1\|407787_407979_+	hypothetical protein	NA	NA	NA	NA
WP_016323807.1\|408257_408482_+	hypothetical protein	NA	NA	NA	NA
WP_016323808.1\|408817_408982_+	hypothetical protein	NA	NA	NA	NA
WP_016323809.1\|409010_409193_+	hypothetical protein	NA	NA	NA	NA
WP_016320839.1\|409593_410391_-	ATP-binding protein	U5N3V8	Enterobacteria_phage	7.0e-55	47.5
WP_040654539.1\|410383_411607_-\|transposase	IS21 family transposase	A0A059NT83	Lactococcus_phage	5.9e-45	33.4
WP_155979082.1\|411725_412064_+	hypothetical protein	Q6JIG5	Burkholderia_virus	1.8e-28	63.2
WP_016323810.1\|412060_412771_+	radical SAM protein	NA	NA	NA	NA
WP_016323812.1\|413358_414372_-\|integrase	tyrosine-type recombinase/integrase	R4JKS7	Mycobacterium_phage	9.0e-07	24.3
WP_081646406.1\|414358_415369_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
425428:425443	attR	NA	NA	NA	NA

DBSCAN-SWA_2

431029 : 439813

Erysipelothrix_phage(33.33%)

integrase

attL 432394:432406|attR 436511:436523

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_016323828.1\|431029_432841_-	hypothetical protein	A0A0U4J920	Pseudomonas_phage	1.9e-23	34.1
432394:432406	attL	NA	NA	NA	NA
WP_016323829.1\|433260_433479_+	hypothetical protein	NA	NA	NA	NA
WP_016323830.1\|433485_433749_+	hypothetical protein	NA	NA	NA	NA
WP_016323831.1\|433738_433945_+	type II toxin-antitoxin system HicB family antitoxin	NA	NA	NA	NA
WP_016323832.1\|434135_434711_+	Uma2 family endonuclease	NA	NA	NA	NA
WP_155979086.1\|435061_435670_+\|integrase	tyrosine-type recombinase/integrase	A0A2I7SC08	Paenibacillus_phage	4.1e-07	27.4
WP_016323835.1\|435647_436199_+\|integrase	site-specific integrase	A0A2H4JCB7	uncultured_Caudovirales_phage	2.0e-16	34.4
WP_016323836.1\|436373_437282_-	recombinase family protein	A0A2K5B2B4	Erysipelothrix_phage	1.1e-61	42.0
436511:436523	attR	NA	NA	NA	NA
WP_016323837.1\|437314_437809_-	hypothetical protein	A0A1X9I6J1	Streptococcus_phage	5.5e-18	42.8
WP_016323839.1\|438931_439813_-	hypothetical protein	A0A2K5B2B2	Erysipelothrix_phage	3.2e-08	30.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage