CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_MDFD01000007	Listeria monocytogenes strain Lm93 contig000007, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000012	Listeria monocytogenes strain Lm93 contig000012, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000022	Listeria monocytogenes strain Lm93 contig000022, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000021	Listeria monocytogenes strain Lm93 contig000021, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000023	Listeria monocytogenes strain Lm93 contig000023, whole genome shotgun sequence	0 crisprs	NA	0	0	1	0
NZ_MDFD01000019	Listeria monocytogenes strain Lm93 contig000019, whole genome shotgun sequence	0 crisprs	cas3,DEDDh	0	0	2	1
NZ_MDFD01000009	Listeria monocytogenes strain Lm93 contig000009, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000008	Listeria monocytogenes strain Lm93 contig000008, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000005	Listeria monocytogenes strain Lm93 contig000005, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000003	Listeria monocytogenes strain Lm93 contig000003, whole genome shotgun sequence	0 crisprs	NA	0	0	1	2
NZ_MDFD01000014	Listeria monocytogenes strain Lm93 contig000014, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000017	Listeria monocytogenes strain Lm93 contig000017, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000011	Listeria monocytogenes strain Lm93 contig000011, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000013	Listeria monocytogenes strain Lm93 contig000013, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000010	Listeria monocytogenes strain Lm93 contig000010, whole genome shotgun sequence	0 crisprs	DinG	0	0	0	0
NZ_MDFD01000006	Listeria monocytogenes strain Lm93 contig000006, whole genome shotgun sequence	0 crisprs	NA	0	0	0	0
NZ_MDFD01000020	Listeria monocytogenes strain Lm93 contig000020, whole genome shotgun sequence	1 crisprs	csa3,WYL	0	0	1	0
NZ_MDFD01000015	Listeria monocytogenes strain Lm93 contig000015, whole genome shotgun sequence	1 crisprs	WYL,casR	2	10	1	0
NZ_MDFD01000004	Listeria monocytogenes strain Lm93 contig000004, whole genome shotgun sequence	1 crisprs	cas3	0	0	0	0
NZ_MDFD01000002	Listeria monocytogenes strain Lm93 contig000002, whole genome shotgun sequence	0 crisprs	csa3	0	0	1	0
NZ_MDFD01000016	Listeria monocytogenes strain Lm93 contig000016, whole genome shotgun sequence	1 crisprs	DinG,csa3	0	0	2	0
NZ_MDFD01000001	Listeria monocytogenes strain Lm93 contig000001, whole genome shotgun sequence	0 crisprs	NA	0	0	1	0
NZ_MDFD01000018	Listeria monocytogenes strain Lm93 contig000018, whole genome shotgun sequence	0 crisprs	NA	0	0	1	0

Results visualization

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

34586 : 68613

Listeria_phage(97.78%)

terminase,tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_012951970.1\|34586_35945_-	recombinase family protein	Q8LTD8	Listeria_phage	1.1e-257	99.8
WP_012951969.1\|36005_37520_-	putative DNA binding domain-containing protein	NA	NA	NA	NA
WP_012951968.1\|37724_38159_-	hypothetical protein	NA	NA	NA	NA
WP_012951967.1\|38217_38925_-	hypothetical protein	A0A0B5CTT6	Listeria_phage	5.3e-123	99.1
WP_012951966.1\|38951_39443_-	hypothetical protein	A8ATX4	Listeria_phage	2.9e-91	99.4
WP_012951965.1\|39473_39779_-	helix-turn-helix transcriptional regulator	A8ASM2	Listeria_phage	1.8e-27	68.5
WP_012951964.1\|39941_40193_+	helix-turn-helix transcriptional regulator	A8ASM3	Listeria_phage	9.3e-22	76.7
WP_003733687.1\|40196_40391_+	hypothetical protein	A0A059T6E5	Listeria_phage	1.4e-25	95.3
WP_012951963.1\|40349_40709_-	DUF2513 domain-containing protein	A0A2H4J4K9	uncultured_Caudovirales_phage	2.1e-06	26.3
WP_012951962.1\|40773_41010_+	hypothetical protein	A0A059T5E9	Listeria_phage	2.8e-36	97.4
WP_012951961.1\|41006_41288_+	hypothetical protein	A8ATX8	Listeria_phage	3.6e-38	96.7
WP_003733684.1\|41289_41487_-	hypothetical protein	Q9T179	Listeria_phage	4.0e-20	96.0
WP_012951960.1\|41550_42327_+	phage antirepressor KilAC domain-containing protein	A0A0B5D0I2	Listeria_phage	9.6e-142	99.2
WP_012951959.1\|42450_42984_+	hypothetical protein	A0A059T5F0	Listeria_phage	1.5e-77	87.9
WP_012951958.1\|42980_43196_+	hypothetical protein	Q9T176	Listeria_phage	9.7e-28	93.0
WP_003722564.1\|43304_43493_+	hypothetical protein	Q9T175	Listeria_phage	1.8e-22	82.3
WP_003734953.1\|43798_43993_+	hypothetical protein	A0A059T6E8	Listeria_phage	1.6e-29	100.0
WP_012951957.1\|43989_44466_+	siphovirus Gp157 family protein	A0A059T5F1	Listeria_phage	9.5e-76	100.0
WP_012951956.1\|44471_45131_+	ERF family protein	A8ASN3	Listeria_phage	5.3e-93	94.1
WP_012951955.1\|45147_46131_+	phage replisome organizer N-terminal domain-containing protein	A8ASN4	Listeria_phage	1.4e-166	91.7
WP_012951954.1\|46127_46415_+	hypothetical protein	A0A059T7V3	Listeria_phage	1.7e-40	88.4
WP_012951953.1\|46411_46942_+	hypothetical protein	A0A059T5F9	Listeria_phage	8.4e-97	95.5
WP_031645470.1\|47077_47308_+	DUF3850 domain-containing protein	A0A059T699	Listeria_phage	1.1e-18	73.8
WP_012951951.1\|47329_47689_+	hypothetical protein	A0A059T801	Listeria_phage	6.6e-45	92.0
WP_012951950.1\|47685_48087_+	hypothetical protein	A8ATZ6	Listeria_phage	1.4e-48	75.9
WP_012951949.1\|48083_48563_+	single-stranded DNA-binding protein	A8ATZ7	Listeria_phage	1.4e-74	91.2
WP_012951948.1\|48584_48962_+	hypothetical protein	NA	NA	NA	NA
WP_031645468.1\|48989_49172_+	hypothetical protein	A8ASP6	Listeria_phage	2.9e-17	81.0
WP_012951947.1\|49116_49521_+	DUF1064 domain-containing protein	A8ASP7	Listeria_phage	1.9e-61	89.6
WP_012951946.1\|49524_49908_+	DUF2481 family protein	A0A0B5CYS3	Listeria_phage	5.7e-63	96.1
WP_012951945.1\|50048_50483_+	hypothetical protein	A8AU03	Listeria_phage	1.6e-74	97.2
WP_012951944.1\|50768_50996_+	hypothetical protein	A8AU06	Listeria_phage	1.5e-34	100.0
WP_012951943.1\|51035_51776_+	hypothetical protein	A0A0B5CTX0	Listeria_phage	2.4e-134	99.6
WP_047934348.1\|51741_53088_+\|terminase	PBSX family phage terminase large subunit	A8ATU6	Listeria_phage	1.1e-262	99.1
WP_012951941.1\|53102_54659_+	hypothetical protein	A8ATU7	Listeria_phage	9.4e-298	97.9
WP_012951940.1\|54663_55707_+	hypothetical protein	A0A0B5D111	Listeria_phage	1.9e-193	96.5
WP_003744996.1\|55802_56357_+	hypothetical protein	A8ATU9	Listeria_phage	1.1e-88	99.5
WP_012951939.1\|56379_57252_+	hypothetical protein	A8ATV0	Listeria_phage	3.0e-160	99.0
WP_012951938.1\|57265_57433_+	hypothetical protein	A8ATV1	Listeria_phage	6.4e-11	97.1
WP_012951937.1\|57433_57787_+	hypothetical protein	A8ATV2	Listeria_phage	7.6e-62	100.0
WP_003733695.1\|57786_58152_+	hypothetical protein	A8ATV3	Listeria_phage	9.9e-65	99.2
WP_012951936.1\|58141_58459_+	HK97 gp10 family phage protein	A8ATV4	Listeria_phage	2.4e-51	98.1
WP_010991155.1\|58455_58827_+	hypothetical protein	A0A0B5CTY4	Listeria_phage	5.5e-63	99.2
WP_012951935.1\|58831_59518_+	Ig domain-containing protein	A0A0B5CYK8	Listeria_phage	2.6e-114	97.4
WP_012951934.1\|59573_60005_+	hypothetical protein	A8ATV7	Listeria_phage	3.2e-70	95.8
WP_074046934.1\|60001_60313_+	hypothetical protein	A0A0B5D116	Listeria_phage	1.3e-41	96.7
WP_012951932.1\|60317_65117_+\|tail	phage tail tape measure protein	A8ATV9	Listeria_phage	0.0e+00	89.1
WP_068995400.1\|66694_68613_+\|tail	phage tail protein	A8ATW1	Listeria_phage	0.0e+00	98.6

Anti-CRISPR protein detection

Acr_ID: NZ_MDFD01000003.1|WP_003733687.1|40196_40391_+|hypothetical-protein

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Acr_ID: NZ_MDFD01000003.1|WP_012951967.1|38217_38925_-|hypothetical-protein

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Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_MDFD01000003.1|WP_003733687.1|40196_40391_+|hypothetical-protein

40196_40391_+

64 aa aa

HTH_XRE

Identity	Hit_domain_coverage
0.5	1.0

34586-68613

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_MDFD01000015_1	Orphan	1.7\|270793\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270793-270827	35	66756-66722	0

1. spacer 1.7|270793|35|NZ_MDFD01000015|PILER-CR,CRT matches to NZ_MDFD01000003 position: 66756-66722, mismatch: 0

tttgttgaatcaacggatatagattttacaatttc	CRISPR spacer
tttgttgaatcaacggatatagattttacaatttc	Protospacer
***********************************

NZ_MDFD01000003.1|WP_012951967.1|38217_38925_-|hypothetical-protein

38217_38925_-

235 aa aa

HTH_XRE

Identity	Hit_domain_coverage
0.41818181818181815	0.9482758620689655

34586-68613

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_MDFD01000015_1	Orphan	1.7\|270793\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270793-270827	35	66756-66722	0

1. spacer 1.7|270793|35|NZ_MDFD01000015|PILER-CR,CRT matches to NZ_MDFD01000003 position: 66756-66722, mismatch: 0

tttgttgaatcaacggatatagattttacaatttc	CRISPR spacer
tttgttgaatcaacggatatagattttacaatttc	Protospacer
***********************************

2. NZ_MDFD01000002

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

32722 : 85101

Streptococcus_phage(30.77%)

protease,tRNA,transposase,integrase

attL 60029:60045|attR 83095:83111

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_171991195.1\|32722_33181_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_012952158.1\|33509_33797_-	hypothetical protein	NA	NA	NA	NA
WP_009911422.1\|33820_34006_-	hypothetical protein	NA	NA	NA	NA
WP_176714737.1\|34103_34253_-	hypothetical protein	NA	NA	NA	NA
WP_069002694.1\|34224_34608_-	DUF669 domain-containing protein	NA	NA	NA	NA
WP_012952156.1\|34619_35258_-	hypothetical protein	NA	NA	NA	NA
WP_009911418.1\|35274_35499_-	hypothetical protein	NA	NA	NA	NA
WP_012952154.1\|35531_35774_-	hypothetical protein	NA	NA	NA	NA
WP_012952153.1\|36169_36526_-	hypothetical protein	NA	NA	NA	NA
WP_012952152.1\|36526_37300_-	hypothetical protein	NA	NA	NA	NA
WP_012952151.1\|37299_38112_-	hypothetical protein	NA	NA	NA	NA
WP_025370672.1\|38083_39340_-	type II/IV secretion system ATPase subunit	NA	NA	NA	NA
WP_012952149.1\|39358_39745_-	hypothetical protein	NA	NA	NA	NA
WP_012952148.1\|39751_39943_-	hypothetical protein	NA	NA	NA	NA
WP_031672440.1\|40000_42316_-	hypothetical protein	NA	NA	NA	NA
WP_012952146.1\|42340_43933_-	hypothetical protein	NA	NA	NA	NA
WP_012952145.1\|43945_44983_-	DUF916 domain-containing protein	NA	NA	NA	NA
WP_012952144.1\|44999_45701_-	WxL domain-containing protein	NA	NA	NA	NA
WP_031672439.1\|45870_46248_-	hypothetical protein	NA	NA	NA	NA
WP_102135382.1\|46268_46727_-\|tRNA	glutamyl-tRNA amidotransferase	NA	NA	NA	NA
WP_140903120.1\|46852_47143_-	hypothetical protein	NA	NA	NA	NA
WP_012952140.1\|47271_47658_-	hypothetical protein	NA	NA	NA	NA
WP_012952139.1\|47707_48682_-	hypothetical protein	NA	NA	NA	NA
WP_012952138.1\|48741_49281_-	hypothetical protein	NA	NA	NA	NA
WP_012952137.1\|49292_49610_-	hypothetical protein	NA	NA	NA	NA
WP_012952136.1\|50201_50756_-	hypothetical protein	NA	NA	NA	NA
WP_012952135.1\|51574_53224_-	primase C-terminal domain-containing protein	NA	NA	NA	NA
WP_026747205.1\|53886_54732_+	ParA family protein	F0PIG8	Enterococcus_phage	3.4e-52	42.6
WP_003726389.1\|54724_55057_+	hypothetical protein	NA	NA	NA	NA
WP_003749815.1\|55608_55956_+	winged helix-turn-helix transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	5.8e-22	46.9
WP_009931074.1\|55933_56299_+	arsenite efflux transporter metallochaperone ArsD	NA	NA	NA	NA
WP_014601544.1\|56344_58069_+	arsenical pump-driving ATPase	NA	NA	NA	NA
WP_003749809.1\|58134_59220_+	ACR3 family arsenite efflux transporter	NA	NA	NA	NA
WP_003749808.1\|59216_59624_+	arsenate reductase (thioredoxin)	A0A2H4PQT9	Staphylococcus_phage	1.5e-29	50.7
WP_039175358.1\|59784_61128_+	Y-family DNA polymerase	M1Q231	Streptococcus_phage	5.0e-122	49.8
60029:60045	attL	NA	NA	NA	NA
WP_003749801.1\|61161_61764_+	hypothetical protein	NA	NA	NA	NA
WP_003749799.1\|61780_62185_+	hypothetical protein	NA	NA	NA	NA
WP_003749797.1\|62181_62478_+	hypothetical protein	NA	NA	NA	NA
WP_014601542.1\|62522_62891_-\|transposase	transposase	NA	NA	NA	NA
WP_031672430.1\|62900_64985_-\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_009932612.1\|64984_66085_-\|integrase	tyrosine-type recombinase/integrase	S6C485	Thermus_phage	1.2e-09	30.9
WP_077913988.1\|66145_67459_-	Y-family DNA polymerase	O64031	Bacillus_phage	2.5e-89	44.5
WP_068995404.1\|67446_67791_-	hypothetical protein	NA	NA	NA	NA
WP_003728505.1\|67995_68730_-	AAA family ATPase	NA	NA	NA	NA
WP_003728466.1\|70348_72484_-	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.6e-247	64.5
WP_003728467.1\|72483_72843_-	Cd(II)-sensing metalloregulatory transcriptional repressor CadC	E4ZFI8	Streptococcus_phage	3.1e-26	50.0
WP_003728468.1\|73122_73677_+	recombinase family protein	A0A0F7LA37	Escherichia_phage	7.0e-38	53.4
WP_003728469.1\|73680_76596_+\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	1.9e-174	36.7
WP_019169200.1\|77778_79824_-	copper-translocating P-type ATPase CopB	A0A218MNH6	uncultured_virus	1.0e-70	31.0
WP_003728472.1\|80099_80663_+	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	2.0e-40	51.1
WP_003728473.1\|80913_82125_+	SIR2 family protein	NA	NA	NA	NA
WP_068995407.1\|82117_83971_+	DUF87 domain-containing protein	NA	NA	NA	NA
83095:83111	attR	NA	NA	NA	NA
WP_002319817.1\|84420_85101_+\|transposase	IS6-like element ISS1N family transposase	A0A1X9I6C6	Streptococcus_phage	2.5e-109	84.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_MDFD01000016

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_MDFD01000016_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_MDFD01000016_1

337257-337365

Orphan

Consensus_repeat	Method
TAAATCAAAATAAAGTACATTTTGAAAGTTCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_MDFD01000016_1

>merge|NZ_MDFD01000016|1|337257-337365|CRISPRCasFinder
TAAATCAAAATAAAGTACATTTTGAAAGTTCTGGGAAGGATTAAATCATCGCTGCGCTCAGATTTATATTGAAGAACTAAATCAAAATAAAGTACATTTTGAAAGTTCT

>NZ_MDFD01000016|1|1|337257-337365|CRISPRCasFinder
TAAATCAAAATAAAGTACATTTTGAAAGTTCT	GGGAAGGATTAAATCATCGCTGCGCTCAGATTTATATTGAAGAAC
TAAATCAAAATAAAGTACATTTTGAAAGTTCT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_MDFD01000016.1\|WP_009931159.1\|340519_341362_-\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223729
NZ_MDFD01000016.1\|WP_012951100.1\|341482_342322_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319818
NZ_MDFD01000016.1\|WP_003722074.1\|328677_329625_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NZ_MDFD01000016.1\|WP_003728589.1\|336467_336650_+\|DUF3188-domain-containing-protein	unknown	unknown	gnl\|CDD\|371501
NZ_MDFD01000016.1\|WP_009913205.1\|343397_343772_-\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	unknown	unknown	gnl\|CDD\|184702
NZ_MDFD01000016.1\|WP_003728590.1\|336243_336465_+\|hypothetical-protein	unknown	unknown	unknown
NZ_MDFD01000016.1\|WP_003732087.1\|330721_332236_+\|gluconokinase	unknown	unknown	gnl\|CDD\|212659
NZ_MDFD01000016.1\|WP_003722061.1\|340228_340474_+\|YaaL-family-protein	unknown	unknown	gnl\|CDD\|378478
NZ_MDFD01000016.1\|WP_003722065.1\|336667_337132_+\|DUF3284-domain-containing-protein	unknown	unknown	gnl\|CDD\|378692
NZ_MDFD01000016.1\|WP_003722073.1\|329667_330606_+\|GW-domain-containing-glycosaminoglycan-binding-protein	unknown	unknown	gnl\|CDD\|226309
NZ_MDFD01000016.1\|WP_012951101.1\|342440_343292_-\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_MDFD01000016.1\|WP_003722062.1\|339617_340214_+\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
NZ_MDFD01000016.1\|WP_003732084.1\|337422_339162_+\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NZ_MDFD01000016.1\|WP_003722063.1\|339191_339509_+\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NZ_MDFD01000016.1\|WP_003732089.1\|326797_328537_+\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|227320
NZ_MDFD01000016.1\|WP_003728591.1\|334744_336109_+\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NZ_MDFD01000016.1\|WP_003732079.1\|344393_345383_-\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|237724
NZ_MDFD01000016.1\|WP_012951102.1\|343775_344372_-\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
NZ_MDFD01000016.1\|WP_009925039.1\|332933_333575_+\|hypothetical-protein	unknown	unknown	unknown
NZ_MDFD01000016.1\|WP_009931588.1\|334146_334302_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_MDFD01000016.1\|WP_009931159.1\|340519_341362_-\|aldo/keto-reductase	gnl\|CDD\|223729	COG0656, ARA1, Aldo/keto reductases, related to diketogulonate reductase [General function prediction only].	6.97706e-130
NZ_MDFD01000016.1\|WP_012951100.1\|341482_342322_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.59066e-84
NZ_MDFD01000016.1\|WP_003722074.1\|328677_329625_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	1.13667e-05
NZ_MDFD01000016.1\|WP_003732087.1\|330721_332236_+\|gluconokinase	gnl\|CDD\|212659	cd07770, FGGY_GntK, Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of a group of gluconate kinases (GntK, also known as gluconokinase; EC 2.7.1.12) encoded by the gntK gene, which catalyzes the ATP-dependent phosphorylation of D-gluconate and produce 6-phospho-D-gluconate and ADP. The presence of Mg2+ might be required for catalytic activity. The prototypical member of this subfamily is GntK from Lactobacillus acidophilus. Unlike Escherichia coli GntK, which belongs to the superfamily of P-loop containing nucleoside triphosphate hydrolases, members in this subfamily are homologous to glycerol kinase, xylulose kinase, and rhamnulokinase from Escherichia coli. They have been classified as members of the FGGY family of carbohydrate kinases, which contain two large domains separated by a deep cleft that forms the active site. This model spans both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Some uncharacterized homologous sequences are also included in this subfamily. The Lactobacillus gnt operon contains a single gntK gene. The gnt operons of some bacteria, such as Corynebacterium glutamicum, have two gntK genes. For example, the C. glutamicum gnt operon has both a gluconate kinase gntV gene (also known as gntK) and a second hypothetical gntK gene (also known as gntK2). Both gluconate kinases encoded by these genes belong to this family, however the protein encoded by C. glutamicum gntV is not included in this model as it is truncated in the C-terminal domain.	0
NZ_MDFD01000016.1\|WP_009913205.1\|343397_343772_-\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	gnl\|CDD\|184702	PRK14484, PRK14484, phosphotransferase mannnose-specific family component IIA; Provisional.	2.28713e-49
NZ_MDFD01000016.1\|WP_003728589.1\|336467_336650_+\|DUF3188-domain-containing-protein	gnl\|CDD\|371501	pfam11384, DUF3188, Protein of unknown function (DUF3188). This bacterial family of proteins has no known function.	4.70726e-11
NZ_MDFD01000016.1\|WP_003722061.1\|340228_340474_+\|YaaL-family-protein	gnl\|CDD\|378478	pfam10704, DUF2508, Protein of unknown function (DUF2508). This family is conserved in Firmicutes. Several members are annotated as being the protein YaaL. The function is not known.	2.68189e-15
NZ_MDFD01000016.1\|WP_003722065.1\|336667_337132_+\|DUF3284-domain-containing-protein	gnl\|CDD\|378692	pfam11687, DUF3284, Domain of unknown function (DUF3284). This family of proteins with unknown function appears to be restricted to Firmicutes.	5.35099e-31
NZ_MDFD01000016.1\|WP_003722073.1\|329667_330606_+\|GW-domain-containing-glycosaminoglycan-binding-protein	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	6.39605e-99
NZ_MDFD01000016.1\|WP_012951101.1\|342440_343292_-\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	3.97147e-62
NZ_MDFD01000016.1\|WP_003722062.1\|339617_340214_+\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	7.77001e-132
NZ_MDFD01000016.1\|WP_003732084.1\|337422_339162_+\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_MDFD01000016.1\|WP_003732089.1\|326797_328537_+\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|227320	COG4987, CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
NZ_MDFD01000016.1\|WP_003728591.1\|334744_336109_+\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	1.91509e-162
NZ_MDFD01000016.1\|WP_003732079.1\|344393_345383_-\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
NZ_MDFD01000016.1\|WP_012951102.1\|343775_344372_-\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	1.69543e-82
NZ_MDFD01000016.1\|WP_003722063.1\|339191_339509_+\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	3.53269e-41

>NZ_MDFD01000016.1|WP_003722065.1|336667_337132_+|DUF3284-domain-containing-protein
MNVTQKLYISQKECFDTLVSSAIYDVKNATGKTLQVRKLEGYKYQRTMSNGALATTKIVKVQPNELYQFETSSRVNTHTTTYTIKSTSETTCEVTYNELIETEKALNKMNNIIVGFMFGFFRKKRVKNLLKSIELSVINESKQKQEKLAAKSEQ
>NZ_MDFD01000016.1|WP_003728589.1|336467_336650_+|DUF3188-domain-containing-protein
MKIVNALFIISIGLIIIMFSPSYGKDGMASVPLLVTGLAVVLIGCVFIVLKIRKDKKEKN
>NZ_MDFD01000016.1|WP_003728590.1|336243_336465_+|hypothetical-protein
MIILNCPMKRDYITELLETHDKDGVTFKKIAEQGMKLTFETNIEDEEKAAKIAKETIKATEIGSVLYFQVSVG
>NZ_MDFD01000016.1|WP_003728591.1|334744_336109_+|PTS-sugar-transporter-subunit-IIC
MNGLTAFLEKYFVPVAAKIGSQKHLVALRDAFISTMPITMAGSIAVLLNAFFRDFPTDWGWTGFVEAMQPLIDINGYVYNGTLAIVSIIFAFSLGYNLSKAYEVDRLAGGLVSLAAFVMNLTVTVSLDAVKAAIAASNANFDVATLPKEFAGIYGFFSLSQVNGTGLFTAMIFGFISTIIYAKLMRRNIIIKMPDSVPPAVSKAFAAIIPALVALYVVGIIDWAFFKITNMDVITWISKTIQEPLLSLSQGYGAVLLVTFLVQLLWFFGIHGPNVLAPVLESLWGTAQLQNISAAQDGAKLPFEWVRGSFDAYVWMGGSGGTLVLIIALLMFSKRADARTVAKLSLAPGIFNINEPIMFGLPIVLNTIYLIPFLIAPMVMVTIAYFATTLGIVGPVKIAVVWVMPPLLNSFLATGGDWMAPVISLINMVVAFLIWVPFVITANRVGVPEEEMKA
>NZ_MDFD01000016.1|WP_009931588.1|334146_334302_-|hypothetical-protein
MAVKRDMPEESKNSKVVKKEHFSIVFPDDIKEPATVEEKKKQDAEKKTDDN
>NZ_MDFD01000016.1|WP_009925039.1|332933_333575_+|hypothetical-protein
MQQLKSKKKWLPALIVAVFVGIIVILAIMFGFFQRQEVFDKYEVAYEIDGKLYEVFPISATDIGVDKKSKDKNLYFRVNSYYNIDYLFRLAYKQYEINEPSTNKYYSGLIDYSVADNAYVTQKDVYITNNESYATYDFFDKNGKKIYTYNPEETSNDDYIVRIKPTILQGYEKSDIGSYDDYLNITALFKDKLGMDVNVRIDEDKEMVIFSIK
>NZ_MDFD01000016.1|WP_003732087.1|330721_332236_+|gluconokinase
MTSKPYIMGVDIGTSSTKAVLFNQRGEVIFRQATHYELITDETGKAEESPTEIFDAVLTSIQAVMKNINTEELAGISFSSAMHSLIMVGSNGELLTECITWADGRSSETLEKVKRDNYLFQLYEATGTPIHPMSPFAKICWLKEEKPTLFKRTEKFVDIKSYILYRLFGVWVMDESLASGTGLYNIMEHDWEFEAMEIVKLTPDFLPKVVPETYQLAGVKKEYAELMGIPENLPFIIGGSDGALANIGIQATGQNDVTITVGTSGAVRKLTDQFQIDSRGRTFCYGAGDGYFIAGGAVNNGGKVVEWGLQQFGSEAEISRRDFASFIAKIEEVPPGAAGLLFQPYLLGERAPFWTNDIRGGFVGLTINHTKAHFIRAILEGVAFNLAEVYEAVSAPDDIIYVTGGISAHDAWCKLLADILNREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKHTLPIKAVYHPSENVLKYAELRLIFKQVTTQLMSSYSQLNSWQKKFDINS
>NZ_MDFD01000016.1|WP_003722073.1|329667_330606_+|GW-domain-containing-glycosaminoglycan-binding-protein
MKKLLSGLIVVLMVSLLGHSFNAEAASYEKIIYDKAVNLKGVVNQSKRNDGINSKMYKTSSSVKYLGSAKKYDKKTLIITREGKTARAKWYYCKLGNTTIGWIDSRAFTNIGKPTIADTVPALWNSKKAIITTKPKSTTATTYFFQKNSAGNWYEVRHFTSHIGKWGFDPKFSEKSSGTPVGVYRTGIAFGQKGNPGTKLTFRAITNRSYWISNSNDKAYNTWQERNSSSSADEKMKIPQYKYGMEVKYNAKRVKGKGSAVFYHVDSPKYNYTLGCVAQSEANTKEVLKFADKNTLIVLGEESRIKTFYGIN
>NZ_MDFD01000016.1|WP_003722074.1|328677_329625_+|LPXTG-cell-wall-anchor-domain-containing-protein
MKKFHGLILTALVTCLIIPFSLAASAETNENGNNSTPTEEKTTDTTENIITEEKTEPAEPTKDTTVTPPQKSKVQTTIDITDSQEVYSYEQNSKIDLKDFTATLTDYTDTKLTNYRLAANSKLSTAQTGIQEVTLLGDNEDGKTTAVKLNYLVKEKTAQLTITDMNFDLETKIFTGKTKPFASVYMSSPADENFGEGTTTADKDGYFYAEWATTPKQITAYAFDESGNYSEEVTYQVPAKKQNEAVVTAPDKVKKIETKNAVKSATTKPTDVTKVTKDDKTDLPSTGDKGTEWIFVVAGVIVILVAVLLLRKRKK
>NZ_MDFD01000016.1|WP_003732089.1|326797_328537_+|thiol-reductant-ABC-exporter-subunit-CydC
MRKSSWIIPYIKENRGLFLLVIFLGTLTFASAGALMFTSGHLISKSSLMPESIMAVYISTVGVRAFGIMRSVSRYVERLSSHSLVLRILEKMRVRLYRLLEPQALLLKSRYKTGDILGLLAGDIEHLQNFYLTTMLPAIVSLVLYAGVVIALGAFSIPFAALFVLLIGLLVLVLPWVSLLYARGKNAYLKQGRNSLYQKFTDAVFGISDWKFSGREKTFISNYEKDEADMLRTENKQFHFVNWRDFFSQLVVGFMVIVMVYWSTAESRDGAFSGTMIAAFVLAIMALAEAFVPVSSAISDKSLYQDSLARLDKIEDPALPTFEEETKEIERINTENVVLKAENLTFAYDEKSPEILNGFDFTLQQGEKVAIIGRSGTGKSTFLKLVQGALLPTAGKVTMNDVEVEKLRPQIPELTSMLNQKAHLFSTTVLNNIRLGNQDASDEEVYEAAKKVQLHDFIMSMPDGYHTQMSEMGERFSGGERGRIALARILLQNTPIVILDEPTVGLDPITERDLLATIFETLADKSLIWVTHHLVGAEKMDRVLFLEEGKTLMEGPHAELMAEEPRYKRLYQLDRPIEL
>NZ_MDFD01000016.1|WP_003732084.1|337422_339162_+|DNA-polymerase-III-subunit-gamma/tau
MAYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAKAINCEHGHDGEPCNECEICKGTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKYKVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPHKLPLTIISRVQRFDFKRITTQDIIGRLKFILEEEKIPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVEDALEITGSVAQNLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPNLEETMERALIDDDFVALAKRADSLKVYEFVKILNTAQQQMRFSNHPGIYVEVALVQLTQAGQSVAGGGNVPADAASGSDVSDLKRQMEQMHQEIQTLKKQIASGAGAAPADKPTQNRGGSKKAINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAASQDTFVLKFKHEIHCQMAMDNPNFVETITSSIARLTQVNYTFIGIPEDQWADVRENFLHSHGSDADAEDGANPEAKKPAEDPFVAEAAKLVGEDLLEIKD
>NZ_MDFD01000016.1|WP_003722063.1|339191_339509_+|YbaB/EbfC-family-nucleoid-associated-protein
MRGMGNMQGMMKQMQKMQKEMAKAQADLEAQEFTGTAGGGMVTVKATGKRVITDVVINEEVVDPEDIEMLQDLVLAATNDVLKQIEDTTSQTMGKFTQGLNIPGM
>NZ_MDFD01000016.1|WP_003722062.1|339617_340214_+|recombination-protein-RecR
MHYPEPITKLIDSFMKLPGIGPKSAARLAFYVLDMKEDDVLDFAKALVDAKRNLSFCSVCGHITDKDPCYICADTSRDRSVICVVQESKDVIAMEKMRDFHGLYHVLHGTISPMDGIGPEDINIPDLLKRLQDDTIEEVILATNPNVEGEATAMYISRLLKPSGIKVTRIAHGLPVGGDLEYADEVTLSKAMEGRREV
>NZ_MDFD01000016.1|WP_003722061.1|340228_340474_+|YaaL-family-protein
MESRSNKFGRKKNKKIGKLHKSYDAYLMELIEVTQENWHKQKVLMRKSFEYDPNLEYEEKKAEARYFYLFKEARTRQLKNK
>NZ_MDFD01000016.1|WP_009931159.1|340519_341362_-|aldo/keto-reductase
MTLSFSDTYRLNNGIEMPRHGFGVYKLTDEARMRTALETAVDVGYRLFDTASFYHNEKELGDFFASSGLKRDEFFVTTKMWNTEQGYDETLRAFEKSQKKLQLDQIDLYLVHWPKQDTFFDTWRAVEKLYDEGLVRAIGVSNFEAHHLDRLRTSANVLPVVDQLETHPHFPNHLLHRYLEELHIVHQAWSPLGRGGVLQEQILIDLAEKHGKSPAQIVLRWHLQNNISIIPKSETPSRIRENAAIYDFELSEADMRQVERLNTGERVSHAPDVMYVRSEI
>NZ_MDFD01000016.1|WP_012951100.1|341482_342322_-|Cof-type-HAD-IIB-family-hydrolase
MTTQAIILDIDGTLLNDDKQISPETKKALITAQENGVKLILASGRPTTGMHVYAEQLEMEKHHGLLVSYNGAKVVDCATNEELFNQALTVEEGKAVLEHMKQFEVKVMIDKEDYMYTNDVYDCYVPYRGEEINIIQYESRGGNFKLCEKDDLAAFLDYRLSKILTAGDPAYMQKNYQAMMAPFKDTLNCVFTADFYFEFTAQGIDKAKALDTVLTPMGIHAENIVAFGDGHNDITMVEYAGTGIAMQNAVVELKAAASSVTLSNNEDGIAHVLNSLIPS
>NZ_MDFD01000016.1|WP_012951101.1|342440_343292_-|MurR/RpiR-family-transcriptional-regulator
MNILIKIRELTNLTNSEKELANYILVNPKKTLQFKPKELAAAAFVSAATIYRLINKLGLNGIGELKIEIASSLRETNAEKDINYDYPILESDTPYQIMTNLNQIYKGTIDETLNNADPEELVKIGEKLINAKTIDVYAASANLFFAQNFKFQMQEIGVLVNVPEEDYIQSLSAANSDENHIAIVVSYGGRSRTLQRVVKILSENNVDIILITSMQDNPLVEFATHKIYMASAENHYNKVSSFSTRQSLLSIFDTLYSIYFNQNYEKNIQYKTTNYQKMNTELE
>NZ_MDFD01000016.1|WP_009913205.1|343397_343772_-|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM
MTKPYGVVIISHSKDVAKGVHDIIKEIAPDVSITHAGGTEDGRIGTSFDAVNEAIESNEADKVYTFYDLGSAKMNIETVEEISEKEIILFNAPILEGAYATAAQVQMDEKPEVIAANLKTIEIK
>NZ_MDFD01000016.1|WP_012951102.1|343775_344372_-|dihydroxyacetone-kinase-subunit-L
MTYDKDWALRWLNDFGERVQENKQLLSDLDQAIGDGDHGINMARGLSELKKVFTEKEPADLKDVFKTAGMTMVSKVGGASGPLYGTAFLNMSKAVDADTIDAVGLTKVIEAGLEGIEKRGKSHAGEKTMIDVWEPVVHALHQEDLTDDVVDAALQKTKDLKATKGRASYLGERSIGHLDPGAYSSALLFHAMLQTEVS
>NZ_MDFD01000016.1|WP_003732079.1|344393_345383_-|dihydroxyacetone-kinase-subunit-DhaK
MKKILNGTDQVVEQMVEGLVKSHADVVHRVEGTRVIARNDKRPGKVGLVSGGGSGHEPAHAGYVGRGMLSAAVCGDVFTSPTPDQIYEGIKAADQGAGVLLIVKNYTGDVMNFEMAADLADADDIKVEQIVVDDDIAVEDSTFTTGRRGVAGTVLVHKIIGAAAEAGASLDELKALGEKVIASVKTLGVALSPCTVPEVGHPGFELGDDEIELGIGIHGEPGFTREKIMPSASLAKQLYERISNESKLLAGDKVVVLVNGMGATPLMEQYVFANDVHELLKNAGVQVAKTLVGDYMTSLEMAGLSLTILKLEDEKWVDMLKLPVDTIAW

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

40656 : 51383

Listeria_phage(40.0%)

tail,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003732227.1\|40656_41385_-	N-acetylmuramoyl-L-alanine amidase	A0A0N9SGH1	Paenibacillus_phage	4.3e-35	42.5
WP_003721755.1\|41365_41788_-\|holin	holin family protein	Q2I8E7	Bacillus_phage	1.1e-27	46.3
WP_003732226.1\|41806_42343_-	hypothetical protein	NA	NA	NA	NA
WP_009931691.1\|42339_42819_-	hypothetical protein	NA	NA	NA	NA
WP_012952080.1\|42833_43409_-	hypothetical protein	NA	NA	NA	NA
WP_003721751.1\|43423_43723_-	hypothetical protein	NA	NA	NA	NA
WP_010958675.1\|43712_44849_-\|tail	phage tail protein	A0A0B5D0G3	Listeria_phage	7.7e-47	33.8
WP_003734720.1\|44858_45677_-\|tail	phage tail family protein	Q9T1A6	Listeria_phage	5.7e-44	35.5
WP_012952081.1\|45673_47542_-	membrane protein	A0A097PAU2	Streptococcus_pyogenes_phage	3.5e-20	45.8
WP_012952082.1\|47528_47933_-	hypothetical protein	A0A097PAX1	Streptococcus_pyogenes_phage	1.1e-19	43.5
WP_003721745.1\|47974_48277_-	hypothetical protein	NA	NA	NA	NA
WP_003721744.1\|48324_48837_-\|tail	phage major tail protein, TP901-1 family	A0A097PBF4	Streptococcus_pyogenes_phage	1.2e-47	62.7
WP_012952083.1\|48849_49239_-	DUF5072 family protein	NA	NA	NA	NA
WP_003732220.1\|49516_49933_-	hypothetical protein	NA	NA	NA	NA
WP_003732219.1\|49944_50373_-	hypothetical protein	A8ATZ8	Listeria_phage	3.0e-12	45.7
WP_003721740.1\|50589_50925_+	helix-turn-helix transcriptional regulator	A0A2H4JAR9	uncultured_Caudovirales_phage	4.0e-20	52.5
WP_003721739.1\|50930_51383_+	ImmA/IrrE family metallo-endopeptidase	A0A059T7S0	Listeria_phage	4.0e-31	47.9

DBSCAN-SWA_2

273170 : 283202

Tupanvirus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_009924391.1\|273170_274625_-	glycoside hydrolase family 1 protein	A0A0B5JD41	Pandoravirus	1.9e-50	30.3
WP_072215787.1\|274652_274961_-	hypothetical protein	NA	NA	NA	NA
WP_012951082.1\|275139_276750_+	ABC-F family ATP-binding cassette domain-containing protein	A0A2K9L3Z8	Tupanvirus	1.2e-45	29.5
WP_012951083.1\|276807_277338_+	ADP-ribose-binding protein	A0A0K1L687	Scale_drop_disease_virus	3.4e-29	49.3
WP_003722118.1\|277625_279092_+	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	8.0e-97	40.0
WP_003732117.1\|279252_281025_+	DNA helicase RecQ	A0A2K9L3P7	Tupanvirus	6.3e-80	37.1
WP_012951084.1\|281048_283202_+	DNA topoisomerase III	A0A1X9I6W8	Streptococcus_phage	6.7e-44	34.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_MDFD01000001

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

88153 : 96439

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003722243.1\|88153_88720_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.0e-25	35.9
WP_012951771.1\|88716_89766_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	4.6e-62	43.5
WP_003722245.1\|89784_91212_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.1e-53	34.6
WP_012951772.1\|91196_93416_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	5.0e-159	41.1
WP_003722247.1\|93408_94092_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_003722248.1\|94095_94341_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_012951773.1\|94352_95066_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	1.2e-42	38.3
WP_003729814.1\|95146_96439_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	2.5e-17	33.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

5. NZ_MDFD01000023

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

69429 : 133711

Listeria_phage(88.0%)

protease,tRNA,holin,portal,capsid,terminase,tail,integrase

attL 64790:64806|attR 104108:104124

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
64790:64806	attL	NA	NA	NA	NA
WP_003736387.1\|69429_70482_+\|tRNA	phenylalanine--tRNA ligase subunit alpha	A0A2I2L4E3	Orpheovirus	2.1e-27	36.0
WP_012951511.1\|70481_72890_+\|tRNA	phenylalanine--tRNA ligase subunit beta	NA	NA	NA	NA
WP_003721621.1\|73050_73752_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.0e-33	35.8
WP_012951512.1\|73765_77176_+	FtsX-like permease family protein	NA	NA	NA	NA
WP_003721623.1\|77273_77726_+	winged helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_003721624.1\|77741_80942_+	MMPL family transporter	NA	NA	NA	NA
WP_003732773.1\|81048_81723_+	uracil-DNA glycosylase	A0A172DS90	Canid_alphaherpesvirus	7.5e-50	47.7
WP_072215733.1\|81760_82687_-	ribonuclease HIII	NA	NA	NA	NA
WP_003740576.1\|82840_83104_+	cell division protein ZapA	NA	NA	NA	NA
WP_012951513.1\|83103_83646_+	CvpA family protein	NA	NA	NA	NA
WP_003723851.1\|83738_85451_+	DNA polymerase/3'-5' exonuclease PolX	A0A2H4UV14	Bodo_saltans_virus	5.1e-18	24.8
WP_010989713.1\|85473_87831_+	endonuclease MutS2	Q94M10	Lactobacillus_phage	1.0e-21	50.4
WP_003723853.1\|87911_88223_+	thioredoxin	A0A1X9I9P5	Staphylococcus_phage	5.4e-19	39.6
WP_003733800.1\|88298_90110_+	excinuclease ABC subunit UvrC	NA	NA	NA	NA
WP_003732778.1\|90298_91513_+	aspartate kinase	NA	NA	NA	NA
WP_003733801.1\|91568_92063_-	YslB family protein	NA	NA	NA	NA
WP_003723856.1\|92210_93011_+	glutamate racemase	NA	NA	NA	NA
WP_003726032.1\|93023_93770_+	ribonuclease PH	NA	NA	NA	NA
WP_012951514.1\|93773_94385_+	XTP/dITP diphosphatase	NA	NA	NA	NA
WP_012951515.1\|94421_94946_+	metallophosphoesterase	NA	NA	NA	NA
WP_068995305.1\|95231_96386_-\|integrase	site-specific integrase	A0A059T688	Listeria_phage	8.2e-214	97.9
WP_014930257.1\|96516_97380_-	hypothetical protein	NA	NA	NA	NA
WP_068995307.1\|97431_97884_-	ImmA/IrrE family metallo-endopeptidase	R4IBK9	Listeria_phage	9.1e-76	87.3
WP_003747248.1\|97900_98224_-	helix-turn-helix transcriptional regulator	R4IDX0	Listeria_phage	2.1e-34	69.2
WP_009931099.1\|99027_99351_+	hypothetical protein	NA	NA	NA	NA
WP_009929536.1\|99365_99569_+	helix-turn-helix transcriptional regulator	A0A059T5F8	Listeria_phage	3.1e-28	100.0
WP_009931097.1\|99570_99813_+	hypothetical protein	A8ATD2	Listeria_phage	5.4e-43	98.8
WP_176714650.1\|100235_100388_+	hypothetical protein	A0A059T7S2	Listeria_phage	7.6e-19	96.0
WP_009931094.1\|100524_100815_+	hypothetical protein	A0A059T7V3	Listeria_phage	1.8e-40	89.4
WP_010991171.1\|100832_101546_+	SAM-dependent DNA methyltransferase	A8ATD5	Listeria_phage	4.1e-131	99.6
WP_068995309.1\|101556_102501_+\|integrase	site-specific integrase	A8ATD6	Listeria_phage	2.3e-174	96.8
WP_010991290.1\|102513_103194_+	hypothetical protein	A8ATD7	Listeria_phage	1.4e-120	96.5
WP_068995312.1\|103190_103562_+	DUF1642 domain-containing protein	Q8W5X2	Listeria_phage	9.6e-15	46.3
WP_061112598.1\|103579_104182_+	hypothetical protein	A8ATU1	Listeria_phage	1.7e-53	52.5
104108:104124	attR	NA	NA	NA	NA
WP_068995314.1\|104317_104527_+	hypothetical protein	NA	NA	NA	NA
WP_068995316.1\|104523_104790_+	hypothetical protein	Q8W5W6	Listeria_phage	5.8e-30	78.8
WP_015987316.1\|104786_104960_+	hypothetical protein	A8ATE7	Listeria_phage	3.1e-24	100.0
WP_023553845.1\|104956_105334_+	hypothetical protein	A8ATE8	Listeria_phage	2.7e-41	66.9
WP_003731665.1\|105337_105817_+	siphovirus Gp157 family protein	R4IBM0	Listeria_phage	7.6e-57	76.7
WP_012951536.1\|105836_106526_+	AAA family ATPase	R4IDY8	Listeria_phage	3.1e-128	96.9
WP_072217948.1\|106604_107846_+	DEAD/DEAH box helicase	A8ATF1	Listeria_phage	3.5e-210	93.4
WP_031640938.1\|107871_108354_+	DUF669 domain-containing protein	A8ATF2	Listeria_phage	9.3e-87	98.1
WP_061691437.1\|108376_110665_+	DNA primase	R4IBW2	Listeria_phage	0.0e+00	93.9
WP_014601407.1\|110998_111316_+	VRR-NUC domain-containing protein	A8ATF4	Listeria_phage	9.2e-51	95.1
WP_003731659.1\|111317_111530_+	hypothetical protein	NA	NA	NA	NA
WP_031644593.1\|111977_112517_+	DUF3310 domain-containing protein	A8ATF5	Listeria_phage	2.7e-74	77.1
WP_003731657.1\|112513_112783_+	hypothetical protein	NA	NA	NA	NA
WP_003731656.1\|112811_112967_+	hypothetical protein	NA	NA	NA	NA
WP_003731655.1\|113027_113255_+	hypothetical protein	NA	NA	NA	NA
WP_003747284.1\|113267_113693_+	DUF722 domain-containing protein	Q8W5V4	Listeria_phage	5.0e-68	92.2
WP_003731652.1\|114276_114591_+	HNH endonuclease	A8ATF8	Listeria_phage	3.2e-56	98.1
WP_012951543.1\|114639_114996_+\|terminase	P27 family phage terminase small subunit	A0A059T7Y1	Listeria_phage	2.0e-46	98.0
WP_023548928.1\|114992_116636_+\|terminase	terminase large subunit	A0A059T7Q8	Listeria_phage	0.0e+00	98.0
WP_023548926.1\|116647_117778_+\|portal	phage portal protein	A8AT96	Listeria_phage	1.7e-203	93.1
WP_068995320.1\|117774_118572_+\|protease	Clp protease ClpP	A0A059T5F2	Listeria_phage	8.1e-136	94.7
WP_009917704.1\|118598_119750_+\|capsid	phage major capsid protein	A8AT98	Listeria_phage	7.2e-202	93.2
WP_023548922.1\|119756_119927_+	hypothetical protein	A8AT99	Listeria_phage	6.9e-21	94.6
WP_009934007.1\|119936_120236_+	hypothetical protein	A8ATA0	Listeria_phage	9.9e-47	98.0
WP_009934006.1\|120219_120585_+	hypothetical protein	A0A059T6F2	Listeria_phage	1.6e-62	96.7
WP_012951550.1\|120581_120983_+	hypothetical protein	A0A059T5F3	Listeria_phage	2.1e-68	100.0
WP_009931623.1\|120979_121363_+	hypothetical protein	A0A059T681	Listeria_phage	6.1e-65	96.1
WP_009931624.1\|121383_121971_+\|tail	phage tail protein	A0A059T7Y4	Listeria_phage	4.0e-108	100.0
WP_014930131.1\|122041_122374_+	hypothetical protein	A0A059T7R2	Listeria_phage	1.1e-51	97.3
WP_009931626.1\|122424_122586_+	hypothetical protein	A0A059T6F4	Listeria_phage	4.3e-20	98.0
WP_068995322.1\|122589_127515_+\|tail	phage tail tape measure protein	A0A059T5F4	Listeria_phage	0.0e+00	92.6
WP_031644613.1\|127502_129152_+\|tail	phage tail family protein	A0A059T682	Listeria_phage	0.0e+00	99.5
WP_012951555.1\|129164_131459_+\|tail	phage tail protein	A0A059T7Y6	Listeria_phage	0.0e+00	94.0
WP_031644619.1\|131448_132543_+	hypothetical protein	A0A059T7R4	Listeria_phage	2.2e-184	87.9
WP_012951557.1\|132590_132893_+	hypothetical protein	A0A059T5E6	Listeria_phage	1.7e-38	93.0
WP_012951558.1\|132892_133150_+\|holin	phage holin	A8ATB7	Listeria_phage	3.2e-25	69.0
WP_068995324.1\|133149_133711_+	M15 family metallopeptidase	A0A059T7Y8	Listeria_phage	2.6e-80	80.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

6. NZ_MDFD01000020

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_MDFD01000020_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_MDFD01000020_1

129423-129579

Orphan

Consensus_repeat	Method
ATTTAGGTAAATTTTGAAAATCAGG	CRISPRCasFinder

2 spacers

The CRISPR arrays of NZ_MDFD01000020_1

>merge|NZ_MDFD01000020|1|129423-129579|CRISPRCasFinder
ATTTAGGTAAATTTTGAAAATCAGGTGTATTGGTTAATAAATTTGCATTTAAATCTAAAAATACGAGATTTGGTAAATTTTGAAAATCAGGAATAGTTGTCAATTGGTTAGAACTTAGATCTAACGTAATAAGTAAAGGAATATTATTAAAATTAGG

>NZ_MDFD01000020|1|1|129423-129579|CRISPRCasFinder
ATTTAGGTAAATTTTGAAAATCAGG	TGTATTGGTTAATAAATTTGCATTTAAATCTAAAAATACGA
GATTTGGTAAATTTTGAAAATCAGG	AATAGTTGTCAATTGGTTAGAACTTAGATCTAACGTAATAA
GTAAAGGAATATTATTAAAATTAGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_MDFD01000020.1\|WP_009924964.1\|127913_128930_+\|NADPH-dehydrogenase-NamA	unknown	unknown	gnl\|CDD\|184110
NZ_MDFD01000020.1\|WP_003722605.1\|125939_126908_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
NZ_MDFD01000020.1\|WP_012952014.1\|132556_133990_+\|polysaccharide-monooxygenase	unknown	unknown	gnl\|CDD\|225932
NZ_MDFD01000020.1\|WP_012952019.1\|121121_122105_+\|UDP-glucose-4-epimerase-GalE	unknown	unknown	gnl\|CDD\|224012
NZ_MDFD01000020.1\|WP_003722610.1\|120043_121003_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
NZ_MDFD01000020.1\|WP_012952010.1\|135901_138064_+\|MMPL-family-transporter	unknown	unknown	gnl\|CDD\|225272
NZ_MDFD01000020.1\|WP_069002703.1\|118489_119965_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
NZ_MDFD01000020.1\|WP_003732488.1\|138142_139069_+\|dipeptidase	unknown	unknown	gnl\|CDD\|366534
NZ_MDFD01000020.1\|WP_003732491.1\|130366_131758_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
NZ_MDFD01000020.1\|WP_012952008.1\|141013_142060_+\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
NZ_MDFD01000020.1\|WP_003722596.1\|135214_135823_+\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
NZ_MDFD01000020.1\|WP_012952018.1\|122121_123183_+\|galactose-mutarotase	unknown	unknown	gnl\|CDD\|185696
NZ_MDFD01000020.1\|WP_012952012.1\|134799_135198_+\|hypothetical-protein	unknown	unknown	unknown
NZ_MDFD01000020.1\|WP_003722600.1\|131803_132400_-\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	unknown	unknown	gnl\|CDD\|178955
NZ_MDFD01000020.1\|WP_069002704.1\|123224_124955_+\|phospho-sugar-mutase	unknown	unknown	gnl\|CDD\|100092
NZ_MDFD01000020.1\|WP_003722604.1\|126915_127887_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|224398
NZ_MDFD01000020.1\|WP_012952009.1\|139227_140571_+\|RNA-polymerase-factor-sigma-54	unknown	unknown	gnl\|CDD\|274109
NZ_MDFD01000020.1\|WP_003722612.1\|117906_118404_+\|acyltransferase	unknown	unknown	gnl\|CDD\|100053
NZ_MDFD01000020.1\|WP_003722606.1\|125062_125938_+\|RNase-adapter-RapZ	unknown	unknown	gnl\|CDD\|235450
NZ_MDFD01000020.1\|WP_012952013.1\|134237_134573_-\|membrane-protein	unknown	unknown	gnl\|CDD\|226719

Protein	Function_ID	Function_description	E-value
NZ_MDFD01000020.1\|WP_009924964.1\|127913_128930_+\|NADPH-dehydrogenase-NamA	gnl\|CDD\|184110	PRK13523, PRK13523, NADPH dehydrogenase NamA; Provisional.	0
NZ_MDFD01000020.1\|WP_003722605.1\|125939_126908_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	1.06416e-165
NZ_MDFD01000020.1\|WP_012952014.1\|132556_133990_+\|polysaccharide-monooxygenase	gnl\|CDD\|225932	COG3397, COG3397, Uncharacterized protein conserved in bacteria [Function unknown].	1.28928e-100
NZ_MDFD01000020.1\|WP_012952019.1\|121121_122105_+\|UDP-glucose-4-epimerase-GalE	gnl\|CDD\|224012	COG1087, GalE, UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane].	0
NZ_MDFD01000020.1\|WP_003722610.1\|120043_121003_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	3.0648e-149
NZ_MDFD01000020.1\|WP_012952010.1\|135901_138064_+\|MMPL-family-transporter	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	3.79318e-131
NZ_MDFD01000020.1\|WP_069002703.1\|118489_119965_+\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	1.80685e-10
NZ_MDFD01000020.1\|WP_003732488.1\|138142_139069_+\|dipeptidase	gnl\|CDD\|366534	pfam01244, Peptidase_M19, Membrane dipeptidase (Peptidase family M19).	7.63415e-121
NZ_MDFD01000020.1\|WP_003732491.1\|130366_131758_+\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	7.80162e-139
NZ_MDFD01000020.1\|WP_012952008.1\|141013_142060_+\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	4.57723e-90
NZ_MDFD01000020.1\|WP_003722596.1\|135214_135823_+\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.34543e-18
NZ_MDFD01000020.1\|WP_012952018.1\|122121_123183_+\|galactose-mutarotase	gnl\|CDD\|185696	cd09019, galactose_mutarotase_like, galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.	4.99806e-149
NZ_MDFD01000020.1\|WP_003722600.1\|131803_132400_-\|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	2.30261e-143
NZ_MDFD01000020.1\|WP_069002704.1\|123224_124955_+\|phospho-sugar-mutase	gnl\|CDD\|100092	cd05799, PGM2, This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
NZ_MDFD01000020.1\|WP_003722604.1\|126915_127887_+\|DNA-binding-protein-WhiA	gnl\|CDD\|224398	COG1481, COG1481, Uncharacterized protein conserved in bacteria [Function unknown].	7.47224e-145
NZ_MDFD01000020.1\|WP_012952009.1\|139227_140571_+\|RNA-polymerase-factor-sigma-54	gnl\|CDD\|274109	TIGR02395, RNA_polymerase_sigma-54_factor, RNA polymerase sigma-54 factor. A sigma factor is a DNA-binding protein protein that binds to the DNA-directed RNA polymerase core to produce the holoenzyme capable of initiating transcription at specific sites. Different sigma factors act in vegetative growth, heat shock, extracytoplasmic functions (ECF), etc. This model represents the clade of sigma factors called sigma-54, or RpoN (unrelated to sigma 70-type factors such as RpoD/SigA). RpoN is responsible for enhancer-dependent transcription, and its presence characteristically is associated with varied panels of activators, most of which are enhancer-binding proteins (but see Brahmachary, et al., ). RpoN may be responsible for transcription of nitrogen fixation genes, flagellins, pilins, etc., and synonyms for the gene symbol rpoN, such as ntrA, reflect these observations [Transcription, Transcription factors].	0
NZ_MDFD01000020.1\|WP_003722612.1\|117906_118404_+\|acyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	1.81171e-27
NZ_MDFD01000020.1\|WP_003722606.1\|125062_125938_+\|RNase-adapter-RapZ	gnl\|CDD\|235450	PRK05416, PRK05416, RNase adapter RapZ.	1.97711e-175
NZ_MDFD01000020.1\|WP_012952013.1\|134237_134573_-\|membrane-protein	gnl\|CDD\|226719	COG4269, COG4269, Predicted membrane protein [Function unknown].	6.49883e-05

>NZ_MDFD01000020.1|WP_009924964.1|127913_128930_+|NADPH-dehydrogenase-NamA
MSKLFSEYKLKDVTLKNRIVMSPMCMYSVENKDGIATDFHFAHYVSRAAGGTGLVILEATAVQEVGRISEFDLGLWNDEQVPALKKLVDGLHYHGAKAGIQLAHAGRKAVLPGEIVAPSAIAFDEKSDKPVELTKEAIKEVVADFKRAAYRAKEAGFDVIEIHAAHGYLIHQFLSPITNRREDNYGGPAGNRYKILSDIIKAVKEVWDGPIIVRVSATDYAHGGLQLEDHIPFAKWMKADGVELIDVSTGGLVNVAPPVFPGYQVPFADEIRRGAGIATGALGLITRGEQAEEILCNERADLIIVGRELLRNPYFAKDAAKQLGETIEAPKQYSRAWK
>NZ_MDFD01000020.1|WP_003722604.1|126915_127887_+|DNA-binding-protein-WhiA
MSFASETKKELTHMDVSDSDAKVELAAFIRMNGAISFSSQLVIMDVQTENAAIARRMYQLLKDLYEVPIELLVRRKMKLKKNNVYIVRLKSGTRGILEDLRILEPPMTFTKSIDRGFVKKRSAKRAYLRGAFLASGSVNNPETSSYHLEIFSVYEEHNEAICALMNQFDLNARTLERKNGFITYLKEAEKITEFLSIIGATSALLHFEDVRIMRDMRNSVNRLVNCETANLNKTINAAVRQIDNIKYIQSTVGLEALPERLREIAALRIANEDVTLKELGEMLTTGQVSKSGINHRLRKLDQIAERLRSGETPAQVGLKISNS
>NZ_MDFD01000020.1|WP_003722605.1|125939_126908_+|YvcK-family-protein
MKKETKPRVVVIGGGTGLPVILKGLKKKDIHLTAIVTVADDGGSSGKIREQMDVLPPGDIRNVMLALSNVDPRVVDLFQYRFAVDGDLSGHVIGNLILTALSQLNDSYVDAINVLATVLKIRGKVIPATDQPLILNAEMEDGSIVHGESLIPLQGKHINRVYIEPENVKPYPTAVEAVKEADLIVIGPGSLYTSILPNLLLTELADEITASKAPKVYITNILTQIGETDFFSDADHIKVIHEHVGKSFIDKTLINTTTVPKELLFPEDVAQVEHNAKGMEELGVEAIYQDFLSTEDGLVRHAAEKVADALLAMLPNQTNEKE
>NZ_MDFD01000020.1|WP_003722606.1|125062_125938_+|RNase-adapter-RapZ
MASKQLKLVIITGMSGAGKTVAMQSLEDLGYFCVDNLPPSLLPKFWELMKESDKMDKIALVMDLRGREFFDSIEPALDELDNTNFITTKILFLEADDKVLVSRYKETRRHHPLEPNGSVLDGINAERELLSDLKGRSQLVINTSNMAPRELRERINNEFQTEDKDIFNVQLMSFGFKYGIPIDADLVFDVRFLPNPHYIDKMRPLTGLDEDVYEYVMKWPETQTFLDKLVDLLMFTLPFYKREGKTQLVIAIGCTGGQHRSVALTEFVGKAIQQKYETTISHRDMKRRKGR
>NZ_MDFD01000020.1|WP_069002704.1|123224_124955_+|phospho-sugar-mutase
MNWQEEYQKWVANDKLDSTLRKQLTNMETNEKELEDSFYRNMEFGTAGMRGVLGAGTNRMNIYTIRKASLGLAQFVAENGEEAKKRGIVIAYDPRHMSREFAFESAAVLGHHGVKSYVFDELRPTPELSFAVRHLNAFGGIVITASHNPPEYNGYKIYGEDGGQMPPTGASAVIEYINAVEDIFSVEVANQELLIENGLLEVISEKVDRPYLEKLKEVIVNKELVQERGEDLKIVFTPLHGTGGILGVPALESVGFTNIVKVDEQFVNDPDFGTVKSPNPENREAFLLAIEYGKKFGGDILVGTDPDADRLGVAVRNADGEYEVLSGNQIGAIILHYLLKQKKAQNELPANAAVLKSIVTSNLGTEIAKHYGAEMIEVLTGFKFIAEQIKHFEETGKHTFEFGYEESNGYMVKPFTRDKDAIQAVLAVAEVALVSKVAGRTLLEDLDQIYDEFGYYNEDLVSLTLSGKDGSRRIKEITSSFREQLPTSMGGFVVERAEDYLRSETTWIATGKTEAIHLPTADVIKCYFEDGSWFCLRPSGTEPKIKFYFSIRGENKEESTAKLEKVKADLMQHIEA
>NZ_MDFD01000020.1|WP_012952018.1|122121_123183_+|galactose-mutarotase
MIFIEVMKERFGEFEGETVWKWTMINDHDMRMSVLNYGAIVTSLETKDKFGDFANINLGFTNLDDYLAHSPYFGATLGPVAGRITNGQFSLDGKQFQLIQNEGSNHRHGGKFNFSKKLWDVSVEKSLDQIVMTFEYCWADGENGYPGKIDAKMTYTLNNKNEWLIDYEARSNQPTIYNPSNHIYFNLSGEAGSTVLQHQLWVNSDSFLPIDEEFLPIGEKRLAENTIFDLRAGREVAEITQSQDQQVKLVGAGLDHTFILKHENGRPDAVLFDPKSGRRLEMETKADSVLIYTANSLDGSFEIDERAVPKYAGITMETQGLVDAINHDGFGDIVLRPEKPFTSRTAFRFTVES
>NZ_MDFD01000020.1|WP_012952019.1|121121_122105_+|UDP-glucose-4-epimerase-GalE
MGIAVLGGAGYIGSHAVDELITRGYEVVVIDNLRTGHRESIHKKAKFYEGDIRDKAFLSSVFEKEKVDGVIHFAASSLVGESMEVPLDYLNNNVYGTQIVLEVMEEFDVKHIVFSSSAATYGEPERVPITEDMPTNPESTYGETKLIMEKMMKWCDKAYGMKFVALRYFNVAGAKADGSIGEDHKPESHLVPIILQVALGQREKLAIYGDDYNTPDGTCIRDYVQVEDLIDAHIRALEYLKNGGESNIFNLGSSNGFSVKEMLEAARTVTGKEIPAEVVPRRAGDPGTLIASSDKASEILGWEPTYTDVKDIIATAWKWHVSHPNGY
>NZ_MDFD01000020.1|WP_003722610.1|120043_121003_+|thioredoxin-disulfide-reductase
MASEEKIYDVIIIGAGPAGMTAALYTSRADLDTLMIERGVPGGQMVNTAEVENYPGFDSILGPDLSDKMLSGAKQFGAEYAYGDIKEVVDGKEFKTVTAGSKTYKARAIIIATGAEHRKLGAAGEEELSGRGVSYCAVCDGAFFKNRELIVVGGGDSAVEEGTYLTRYADKVTIVHRRDKLRAQQILQDRAFKDEKVDFIWNSTVEEIVGDGKKVTGAKLVSTVDGSESIMPVDGVFIYVGLVPLTKAFLNLGITDDEGYIVTDEEMRTNLPGIFAAGDVRAKSLRQIVTATGDGGLAGQNAQKYVEELKESLEAEAAK
>NZ_MDFD01000020.1|WP_069002703.1|118489_119965_+|hypothetical-protein
MEKDKKIPAKIYPFYPNGQFYFERGVEAFRDQRIKEAIRYLVRASELEPGEAVILCQLAICYTEIGQFHKSNQLLREVLEQRNGNMEYCYYFIANNFAYMKDYRRALQYANRYLDSSTDGEYTEEAKDLIEVLLEETPFGETIENGFSKLEQEFYSYKKEINRYLAEEDSASACDILRKVIDEKPNFWPAYNQLASLYFEQLKEEEGVRVLSDLLSRNPGNLLGICDLFIYHFYKGNRKEADEFYLELRDVLPVLAHHKEKLGLIHAMMGEYEEADDLLEQVADLEVTERSKYYYFRAKSSYYLGDVEGAKMFWHSFLECDLYEDVRFPWEQEPDLTNDTRLVLEMLQEEDDLTHMLGVYALTISGNRPELVLFHPLLDMSDWSYMEHLMFTNFDYFPDGAIEQNGYLIAKAMIILKENGILLNEEYMALYKQMFSLVLIDAGKDLILGRYTIETVASAIAKLFLPHLKLQLVEEFECSKCARDIERVLSR
>NZ_MDFD01000020.1|WP_003722612.1|117906_118404_+|acyltransferase
MRRLDRFNAPDDTVNTLFQVYKTISFWKVLKNTLVIEFGRFFPWMGGKRKIYRVCLGMEIGEKTAIAYKVMPDLFFPEKILIGENSIIGYHTTILTHEYLLSEYRVGEVVIGRDVMVGANVTILPGTVIGDGAVIAAGAVVSVDVPAGSFAYGNPLIIKEKATLT
>NZ_MDFD01000020.1|WP_003732491.1|130366_131758_+|amino-acid-permease
MTKVNSFFRKKSFHNPATDKHHLNKSLGAFDLTMLGVGAVVGGGIFILPGQVASVIAGPGIIISFIIAGIACCLAALCYSEFASKLPVAGSAYTYSYHVFGEGVAWILGWSLILEYGLAVAAIASGWSSYMKSLLAGFDLHIPTAISSAYDPSAGTYFDLLAFVVVMVIGILLSFGIRESTRVNNIMVLVKIAVVVLFILVGAFYVKPDNWTPFLPFGVQGVITGASTVFFAYIGFDAVSSAAEEVKNPQKNMPIGIISSLAVCTLLYILLSAVLTGVVPYTDLVDVSAPVAFALQAINQNWIAGLLSVGAIVGMTTVVLVMSYGGTRLLFAMGRDGLLPKSFSKISKNDTPVRNTMIFATVMGLIASTVPMADLAQLINIGTLFAFAMVSIGIFFLRRNPDLNQKGFKTPFYPVVPALSFLLCVYLMINLSKTTWIAFGIWFVIGILVYTFYGRKHSALRIK
>NZ_MDFD01000020.1|WP_003722600.1|131803_132400_-|ATP-dependent-Clp-endopeptidase-proteolytic-subunit-ClpP
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDIFLYINSPGGSISAGMAIYDTMNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEIMIHQPLGGAQGQATEIEIAARHILKIKERMNTIMAEKTGQPYEVIARDTDRDNFMTAQEAKDYGLIDDIIINKSGLKG
>NZ_MDFD01000020.1|WP_012952014.1|132556_133990_+|polysaccharide-monooxygenase
MKKMTKIGMFFAVFTLAVVLFQTTASAHGYISKPASRVYLANKGINVGVGSAQYEPQSVEAPKGFPISGPADGSIAGGGKYSLLDEQSASRWAKVDIEPGPLTVEWTLTAPHKTSSWQYFITKKGWDPNKPLTRSSLEPLATIEADGSVPNALAKQEINIPNDRSGYYVILGVWNIADTGNAFYQVIDANIINSDITPVADTEAPTKPTNLAATTTKTVSLAWNASTDNVGIKGYEILRDGVVIGESQTASYEDTTVESNTAYTYTVRAKDFAGNKSTLSNSINVTTKEVPAVDNEAPTAPKSLMSHGQTDTTIALCWQASTDNVEVKNYEIYRNNTKIATSTKTMFEDTKLASNTSYNYKVYAVDTSGNRSLVSNEITIKTKTLDPLNTWKSDQIYNAGDQVYYNGVAYTAKWWTKGNTPDTSDVWQTASTDIQTWNVQKAYNGGDKVTYNGKTYQAKWWVRGEKPDSSSIWTLLN
>NZ_MDFD01000020.1|WP_012952013.1|134237_134573_-|membrane-protein
MVEQNYMETRNGRTSFFDGGLLQYIGWTILGTLVTLCTFGICYPWALCMVYGWKINHTVIEGRRLKFQGSAVSLFGHWVKWLLLTIITIGIYGFWVFIKLEDWKVKNTIFN
>NZ_MDFD01000020.1|WP_012952012.1|134799_135198_+|hypothetical-protein
MAASLKDRLEEEVKTYSADNNLTVQTIDFLYAGPHMRGRHSLVLAFTEAGIFTFVFKLSDAEMHFLDGKTVQQIALEKKKLVYRLYIRAVTEEGELEEGKYLVSKRVLGRKWHKETLEKLINKNLPLLTATK
>NZ_MDFD01000020.1|WP_003722596.1|135214_135823_+|TetR/AcrR-family-transcriptional-regulator
MEKKRTRAEELGITRRKILDTARDLFMEKGYRAVSTREIAKIANITQPALYHHFEDKESLYIEVVRELTQNIQVEMHPIMQTNKAKEEQLHDMLIMLIEEHPTNILLMIHDILNEMKPENQFLLYKLWQKTYLEPFQQFFERLENAGELRNGISAETAARYCLSTISPLFSGKGSFAQKQTTTEQIDELINLMMFGICKKEV
>NZ_MDFD01000020.1|WP_012952010.1|135901_138064_+|MMPL-family-transporter
MKDGFLSKIASGVGGKKGRFITLGIWIIAIIILQFFFPKAADYKDDAAKDLPNSEPSVVAQKLIDDKFAGTDGVPALITWYRSTGLTNEDLVNIQKYSKELTENPVDYQKMAVPYDKMPPVVLKQQVSKDGTTFIQTVIMKDSATSDQLTESFKQLESAAKTTIGEDPFAQKVSADDTLVARTTGPAGISVDASGLFKDADVSLLIGTVLLVLVFLLVIYRSPILALIPLIAVGFAYLVITPILGLLAKEGIITYGSQGLSIMTVLLFGAGTDYCLFLISRFRSHLHTEKNRFQAFKEAFSGTAGAIALSGLTVMAALLLLLAAEYGSFHNFAVPFSLAIFIMMISSLTLVPALLGIFGRVSFWPFVPRTVEMEETRAKKKGKTPKHHKENRFWHKIGEMSAKHPVRILIITLIILIGCGIFTTQVKYTYDTLSTFPEDMPSREGFTLISDHFGAGMLAPMEVVVNSKESMKSSLENVDGVASVTGPERSKGYQKYTLILKDNPYSNEAMDVVPKVRAAADKGNDVYIAGQTATQYDDRAVTEHDEKVIIPLVIALIAILLLCYLRSITAMLYLVATVLLSFVGALGLGWVIIHYAMGVEAISGLIPLYAFVFIVALGEDYNIFMISSIWKNSKKMPIRKAITEGVGQTGGVITSAGLILAGTFGVLTTLPIQLLVQFGLITAIGVLLDTFIVRPFLVPSITVLLGKWAFWPGKQHKMTK
>NZ_MDFD01000020.1|WP_003732488.1|138142_139069_+|dipeptidase
MRVIDTHCDALYKLQAGKGKYTFQDAEELDVNFERLIEAKMLLQGFAIFLDEDIPVEHKWKKAVEQVNIFKQHVLHKGGIIHHVKKWCDLENLPEDKIGAMLTLEGIEPIGRDLDKLTQLLDGGVLSVGLTWNNANLAADGIMEERGAGLTRFGKDIIHLLNERKVFTDVSHLSVKAFWETLEQAEFVIASHSSAKAICAHPRNLDDEQIKAMIEHDAMIHVIFHPLFTTNDGVADIEDVIRHIDHICELGGMKNIGFGSDFDGIPDHVKGLEHAGKYQNFLETLGKHYTKEEVEGFASRNFLNHLPK
>NZ_MDFD01000020.1|WP_012952009.1|139227_140571_+|RNA-polymerase-factor-sigma-54
MRLESNFVQKQQQKQSQKLNMTQQLSQSIAMLQFATADLVAFLEDKALENPLIEVIPGSDFATDFSYSSRKSAGSSDDTDWLEQIADNKMTLADALKEQLHLMDVTQTQKIIVLYLIESLNDNGYLQIDLKDVSAALLMDDSSVLEGLEILQSMEPAGVGARDARECILLQIERSPDAPYIAYDVIQKFFTEFAEKKWKKIASEMDVSLQDIQEVSDYIQTLNPKPGSEFESERVQYVVPDLILLQHEDEFAVSLAKQFLPQVRFQEAYYETMRATEEKDVAQFLREKAGEFDWIKKGIEQRESTLQRVGEAIVSHQKAYFLDNSAHLQPLTLKEVAEELGVHESTVSRAVNGKYMETTNGVYELKRFFASGLQKKSSENENIGDISSTTIKMLVQEFVAAEDKLKPLSDQKIVDMLAEKEIQVSRRAIAKYRLELNIPSSSKRKRF
>NZ_MDFD01000020.1|WP_012952008.1|141013_142060_+|sugar-binding-transcriptional-regulator
MSDLINIQKKLLPDVLLIMQKRYQILRSIYFSEPVGRRTLAGMLGMSERVLRGEVEFLKAQGLVEIASSGMTVTKEGLVVFRDLESVMNQLSGLHSMEEQLAKKLQIKKCLVVQGDSDDTPWVREEMGRVAVEQLDMALTEKRNIVAVMGGSTMATVAEMMTTDFAKGRELLFVPGRGGIGEDLDNQANTICDKMATKTNTKHRVLYVPEQLGEEAYRSLLKEPAIQEGLRLVQSANAIILGIGDALAMAKRRHTGEDVLGKIIHRKAVGEAFGYYFDEQGEVVHKVPTFGLQFEDLAQIPHIIAVAGGTSKAKAIKSYMKSAPKNTILITDEGAAKSLLKGSNTLLK

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

120043 : 127887

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003722610.1\|120043_121003_+	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.0e-88	53.7
WP_012952019.1\|121121_122105_+	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	4.0e-52	38.4
WP_012952018.1\|122121_123183_+	galactose mutarotase	NA	NA	NA	NA
WP_069002704.1\|123224_124955_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	3.9e-175	54.0
WP_003722606.1\|125062_125938_+	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	1.9e-08	29.7
WP_003722605.1\|125939_126908_+	YvcK family protein	A1IMD5	Streptococcus_phage	6.7e-68	43.3
WP_003722604.1\|126915_127887_+	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	5.2e-52	39.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

7. NZ_MDFD01000019

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 7653

Listeria_phage(62.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_068995339.1\|0_334_-	hypothetical protein	A8ATW6	Listeria_phage	2.2e-55	94.6
WP_003722518.1\|358_808_-	anti-CRISPR protein AcrIIA1	A8ATW7	Listeria_phage	2.4e-76	100.0
WP_003731276.1\|808_1060_-	hypothetical protein	A8ATW8	Listeria_phage	2.0e-40	100.0
WP_003731277.1\|1091_1325_-	hypothetical protein	A8ATW9	Listeria_phage	4.3e-13	100.0
WP_012951563.1\|1626_1860_+	hypothetical protein	A8ATC5	Listeria_phage	1.6e-36	98.7
WP_012951565.1\|2507_3866_+	DUF1254 domain-containing protein	M1HNU9	Paramecium_bursaria_Chlorella_virus	7.6e-09	21.6
WP_012951566.1\|3906_4500_-	DUF1801 domain-containing protein	NA	NA	NA	NA
WP_009914084.1\|4653_5061_-	glyoxalase/bleomycin resistance/extradiol dioxygenase family protein	NA	NA	NA	NA
WP_009924169.1\|5225_5825_+	histidine phosphatase family protein	A0A1X9IGJ2	Lactococcus_phage	5.8e-30	41.0
WP_003723543.1\|5856_6117_-	hypothetical protein	NA	NA	NA	NA
WP_010989717.1\|6240_7653_+	ATP-dependent RNA helicase DbpA	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	8.3e-51	31.8

DBSCAN-SWA_2

21002 : 80442

Bacillus_virus(16.67%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003723562.1\|21002_22142_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_003723563.1\|22222_22618_-	helix-turn-helix transcriptional regulator	A9D9J6	Lactobacillus_prophage	1.3e-14	57.4
WP_003727524.1\|22768_22984_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_010989719.1\|23102_23636_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_003732795.1\|23653_24319_+	hypothetical protein	NA	NA	NA	NA
WP_003732796.1\|24580_25519_+	hypothetical protein	NA	NA	NA	NA
WP_003723884.1\|25633_26917_+	trigger factor	NA	NA	NA	NA
WP_003723886.1\|27101_28361_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.4e-145	63.2
WP_003723887.1\|28479_29046_+	type I signal peptidase SipX	NA	NA	NA	NA
WP_009924619.1\|29080_29650_+	type I signal peptidase SipY	NA	NA	NA	NA
WP_003723889.1\|29751_30294_+	type I signal peptidase SipZ	NA	NA	NA	NA
WP_003723890.1\|30303_31167_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_003723891.1\|31163_31949_+	ribonuclease HII	G4YAY0	Emiliania_huxleyi_virus	3.0e-26	39.2
WP_003723892.1\|32082_32943_+	DNA-protecting protein DprA	S6BFL3	Thermus_phage	1.2e-39	43.2
WP_012951572.1\|33214_35293_+	type I DNA topoisomerase	A0A1V0SB35	Catovirus	3.2e-107	37.5
WP_009924616.1\|35355_36660_+\|tRNA	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	NA	NA	NA	NA
WP_009911635.1\|36942_37845_+	tyrosine recombinase XerC	A0A1B1IQT7	uncultured_Mediterranean_phage	8.0e-23	28.0
WP_003724001.1\|37865_38405_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_003732800.1\|38418_39828_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A1B2IBU3	Erwinia_phage	6.8e-29	25.6
WP_003726695.1\|39848_40628_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_012951573.1\|40730_41150_+	acyl-CoA thioesterase	NA	NA	NA	NA
WP_003724130.1\|41172_41484_+	hypothetical protein	NA	NA	NA	NA
WP_009932949.1\|41486_42359_+	aldose 1-epimerase family protein	NA	NA	NA	NA
WP_003724132.1\|42400_42997_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_003732802.1\|43154_43562_+	CoA-binding protein	NA	NA	NA	NA
WP_003723731.1\|43742_45710_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	6.7e-123	42.5
WP_010989723.1\|45706_48166_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	4.7e-102	31.6
WP_009913867.1\|48248_48716_+	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_012951574.1\|49042_50776_+	LapB repeat-containing protein	NA	NA	NA	NA
WP_012951575.1\|51107_52904_+	class 1 internalin InlK	NA	NA	NA	NA
WP_012951576.1\|52937_54806_-	peptidoglycan O-acetyltransferase OatA	B5WZU0	Pseudomonas_phage	6.5e-43	31.9
WP_012951577.1\|55018_55717_+	glycerophosphodiester phosphodiesterase	A0A0S2MYI4	Enterococcus_phage	9.9e-13	32.4
WP_003723738.1\|55949_57626_+	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_012951578.1\|57751_58669_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_003719566.1\|58791_59025_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_003733804.1\|59135_60359_+	GTPase HflX	NA	NA	NA	NA
WP_010989728.1\|60351_61578_+	methionine gamma-lyase family protein	NA	NA	NA	NA
WP_003719570.1\|61780_62149_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_003723435.1\|62219_63554_+	type I glutamate--ammonia ligase	M1NM71	Moumouvirus	4.2e-12	23.8
WP_012951579.1\|63697_64993_+	arsenic transporter	A0A2H4PQU3	Staphylococcus_phage	2.8e-146	61.9
WP_003723437.1\|65036_65558_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_003723438.1\|65587_66202_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	9.3e-15	62.1
WP_003723439.1\|66359_66689_+	cell division suppressor protein YneA	NA	NA	NA	NA
WP_003723440.1\|66780_67008_+	DUF896 domain-containing protein	NA	NA	NA	NA
WP_003732809.1\|67154_69149_+	transketolase	NA	NA	NA	NA
WP_003723442.1\|69369_69609_+	YneF family protein	NA	NA	NA	NA
WP_003723443.1\|69659_70502_-	DUF2785 domain-containing protein	NA	NA	NA	NA
WP_003723445.1\|71273_71780_-	ParB-like nuclease domain-containing protein	A0A220GKT8	Streptococcus_phage	4.0e-56	66.7
WP_003723446.1\|71789_73094_-	DUF3440 domain-containing protein	A0A220GKF8	Streptococcus_phage	9.5e-134	52.1
WP_072217143.1\|73083_74289_-	helicase SNF2	L0P6E9	Lactobacillus_phage	3.7e-92	47.1
WP_003723448.1\|74266_74641_-	hypothetical protein	NA	NA	NA	NA
WP_003723449.1\|74933_75662_+	UMP kinase	NA	NA	NA	NA
WP_003723450.1\|75661_76219_+	ribosome recycling factor	NA	NA	NA	NA
WP_003732812.1\|76448_77207_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	4.4e-22	42.1
WP_003732813.1\|77220_78009_+	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_010989733.1\|78023_79166_+	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_003723454.1\|79179_80442_+\|protease	RIP metalloprotease RseP	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_MDFD01000019.1|WP_003731276.1|808_1060_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_MDFD01000019.1|WP_003731276.1|808_1060_-|hypothetical-protein

808_1060_-

83 aa aa

AcrIIA12

hit_Aca_id	identity	query_coverage	hit_coverage
anti_CRISPR3641\|WP_003731276.1\|AcrIIA12\|II-A\|Verified\|Listeria-monocytogenes	1.0	1	1.0

0-7653

8. NZ_MDFD01000015

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_MDFD01000015_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_MDFD01000015_1

270379-270856

Orphan

I-A

Consensus_repeat	Method
GTTTTAGTTACTTATTGTGAAATGTAAAT	PILER-CR
GTTTTAGTTACTTATTGTGAAATGTAAAT	CRT
TTTTAGTTACTTATTGTGAAATGTAAAT	CRISPRCasFinder

7 spacers

The CRISPR arrays of NZ_MDFD01000015_1

>merge|NZ_MDFD01000015|1|270379-270856|PILER-CR,CRT,CRISPRCasFinder
GTTTTAGTTACTTATTGTGAAATGTAAATACAGATCAAACTCCGGAAGGGTGATTGTAAATGGCGTTTTAGTTACTTATTGTGAAATGTAAATTGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGCGTTTTAGTTACTTATTGTGAAATGTAAATGCGATTTTTGTCAAAGGGACAGCGATGGGTTACAAGTTTTAGTTACTTATTGTGAAATGTAAATTTTTCTACTCCTGCTTCTAAAATGTCGTTTATAAGTTTTAGTTACTTATTGTGAAATGTAAATCTAAAACATCCTTCACTGTATCAACTCCTTTCTATATTTTAGTTACTTATTGTGAAATGTAAATAAAATAGGAGGAAATAAATTATGACTATCAAATTAAGTTTTAGTTACTTATTGTGAAATGTAAATTTTGTTGAATCAACGGATATAGATTTTACAATTTCGTTTTAGTTACTTATTGTGAAATGTAAAT

>NZ_MDFD01000015|1|1|270379-270856|PILER-CR
GTTTTAGTTACTTATTGTGAAATGTAAAT	ACAGATCAAACTCCGGAAGGGTGATTGTAAATGGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTTTCTACTCCTGCTTCTAAAATGTCGTTTATAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	CTAAAACATCCTTCACTGTATCAACTCCTTTCTAT
ATTTTAGTTACTTATTGTGAAATGTAAAT	AAAATAGGAGGAAATAAATTATGACTATCAAATTAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTTGTTGAATCAACGGATATAGATTTTACAATTTC
GTTTTAGTTACTTATTGTGAAATGTAAAT

>NZ_MDFD01000015|1|1|270379-270856|CRT
GTTTTAGTTACTTATTGTGAAATGTAAAT	ACAGATCAAACTCCGGAAGGGTGATTGTAAATGGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTTTCTACTCCTGCTTCTAAAATGTCGTTTATAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	CTAAAACATCCTTCACTGTATCAACTCCTTTCTAT
ATTTTAGTTACTTATTGTGAAATGTAAAT	AAAATAGGAGGAAATAAATTATGACTATCAAATTAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTTGTTGAATCAACGGATATAGATTTTACAATTTC
GTTTTAGTTACTTATTGTGAAATGTAAAT

>NZ_MDFD01000015|1|1|270380-270856|CRISPRCasFinder
TTTTAGTTACTTATTGTGAAATGTAAAT	ACAGATCAAACTCCGGAAGGGTGATTGTAAATGGCG
TTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGCG
TTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAAG
TTTTAGTTACTTATTGTGAAATGTAAAT	TTTTCTACTCCTGCTTCTAAAATGTCGTTTATAAG
TTTTAGTTACTTATTGTGAAATGTAAAT	CTAAAACATCCTTCACTGTATCAACTCCTTTCTATA
TTTTAGTTACTTATTGTGAAATGTAAAT	AAAATAGGAGGAAATAAATTATGACTATCAAATTAAG
TTTTAGTTACTTATTGTGAAATGTAAAT	TTTGTTGAATCAACGGATATAGATTTTACAATTTCG
TTTTAGTTACTTATTGTGAAATGTAAAT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_MDFD01000015.1\|WP_012951250.1\|273843_275679_+\|lmo0514-family-class-1-internalin	unknown	unknown	gnl\|CDD\|380190
NZ_MDFD01000015.1\|WP_012951247.1\|271247_271826_+\|hypothetical-protein	unknown	unknown	unknown
NZ_MDFD01000015.1\|WP_014601718.1\|272637_272997_-\|Lin0512-family-protein	unknown	unknown	gnl\|CDD\|131113
NZ_MDFD01000015.1\|WP_012951246.1\|266424_267471_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_MDFD01000015.1\|WP_012951243.1\|261431_262082_+\|transaldolase	unknown	unknown	gnl\|CDD\|223254
NZ_MDFD01000015.1\|WP_012951244.1\|264254_264857_+\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223865
NZ_MDFD01000015.1\|WP_003721303.1\|277808_278624_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_MDFD01000015.1\|WP_003721297.1\|271932_272613_+\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_MDFD01000015.1\|WP_003721290.1\|265368_265767_+\|hypothetical-protein	unknown	unknown	unknown
NZ_MDFD01000015.1\|WP_003733191.1\|264884_265352_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129
NZ_MDFD01000015.1\|WP_003721301.1\|275779_276211_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_MDFD01000015.1\|WP_003721294.1\|267794_269066_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_MDFD01000015.1\|WP_012951252.1\|278904_279273_-\|DUF1304-domain-containing-protein	unknown	unknown	gnl\|CDD\|226282
NZ_MDFD01000015.1\|WP_003733187.1\|273003_273462_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378956
NZ_MDFD01000015.1\|WP_012951251.1\|276257_277688_-\|CapA-family-protein	unknown	unknown	gnl\|CDD\|225399
NZ_MDFD01000015.1\|WP_012951245.1\|265777_266428_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NZ_MDFD01000015.1\|WP_003733193.1\|262190_264251_+\|BglG-family-transcription-antiterminator	unknown	unknown	gnl\|CDD\|226234
NZ_MDFD01000015.1\|WP_003727295.1\|279419_280835_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_MDFD01000015.1\|WP_003721293.1\|267486_267780_+\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NZ_MDFD01000015.1\|WP_003733190.1\|269205_270141_+\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|234929

Protein	Function_ID	Function_description	E-value
NZ_MDFD01000015.1\|WP_012951250.1\|273843_275679_+\|lmo0514-family-class-1-internalin	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	8.58129e-120
NZ_MDFD01000015.1\|WP_003721303.1\|277808_278624_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.01016e-50
NZ_MDFD01000015.1\|WP_014601718.1\|272637_272997_-\|Lin0512-family-protein	gnl\|CDD\|131113	TIGR02058, lin0512_fam, conserved hypothetical protein. This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N-terminus. [Hypothetical proteins, Conserved].	4.36834e-66
NZ_MDFD01000015.1\|WP_012951246.1\|266424_267471_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	0
NZ_MDFD01000015.1\|WP_012951243.1\|261431_262082_+\|transaldolase	gnl\|CDD\|223254	COG0176, MipB, Transaldolase [Carbohydrate transport and metabolism].	1.0547e-61
NZ_MDFD01000015.1\|WP_003721297.1\|271932_272613_+\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	7.71833e-60
NZ_MDFD01000015.1\|WP_012951244.1\|264254_264857_+\|SIS-domain-containing-protein	gnl\|CDD\|223865	COG0794, GutQ, Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane].	5.57544e-75
NZ_MDFD01000015.1\|WP_003733191.1\|264884_265352_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	2.76446e-37
NZ_MDFD01000015.1\|WP_003721301.1\|275779_276211_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.03126e-27
NZ_MDFD01000015.1\|WP_003721294.1\|267794_269066_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	7.01085e-178
NZ_MDFD01000015.1\|WP_012951252.1\|278904_279273_-\|DUF1304-domain-containing-protein	gnl\|CDD\|226282	COG3759, COG3759, Predicted membrane protein [Function unknown].	8.73125e-42
NZ_MDFD01000015.1\|WP_003733187.1\|273003_273462_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	1.03599e-12
NZ_MDFD01000015.1\|WP_012951251.1\|276257_277688_-\|CapA-family-protein	gnl\|CDD\|225399	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane].	7.01384e-100
NZ_MDFD01000015.1\|WP_012951245.1\|265777_266428_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	8.25352e-108
NZ_MDFD01000015.1\|WP_003733193.1\|262190_264251_+\|BglG-family-transcription-antiterminator	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	3.95572e-80
NZ_MDFD01000015.1\|WP_003727295.1\|279419_280835_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.97112e-80
NZ_MDFD01000015.1\|WP_003721293.1\|267486_267780_+\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	3.06007e-27
NZ_MDFD01000015.1\|WP_003733190.1\|269205_270141_+\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	1.26262e-153

>NZ_MDFD01000015.1|WP_003733190.1|269205_270141_+|ribose-phosphate-pyrophosphokinase
MAGKMKLFSVTSERPLATKIADYLDIPLCEVELQKFSDGEVKINIEESIRGTNAYVVQSMNSNVNERLMELLIMVDALKRASVHSINIIMPYYGYARQDRKARSREPITAKLMANLIQRAGANRLITVDLHAAQIQGFFNIPIDHLSAIPLIGDYLIENYGEKDVVVVAPDHSGVVRARRIADRLNAPIAILNRKPRPHEDEIMSVIGDVKGKVAIVVDDIIDTGVRATTSADILLEKGAVEVIACATHSVMAGNATERLQNSNIKEVITSDSIDLPEDKQFDKLTTISIGRILGRAIEGVQENRSLHPLF
>NZ_MDFD01000015.1|WP_003721294.1|267794_269066_+|PTS-galactitol-transporter-subunit-IIC
MDIILDFFKYIIGLGVTVMMPIIITILGVIFRKKISVAFKAGLTVGVGFVGLGVITSLMLTTITPVTKALVENYNFKLTATDIGWGVGSSLAWGTEVVPFVFVAIIATNILMIAFKWTKTMDVDIWNYWQPLFIASALYLTTGSMIIAVLSSIINMAIIFKIADWTQKDVEDVLGLEGISLPQIQTTGWALVGYPMNWLLGKIPGVRKINWSTEKVQSRLGIFGEPMLMGLIIGGGLAAIAQMPLSQVLQTGVTIAASLVLIPRMVSLLMDGLTVISEAAHEFMEKRFPGRELFIGLDSAVGIGHPFVLSLGLLMIPITLILAFILPGNKVLPLADLTALPFYMIFAIVPSKGNLFRGIFTGIVIVIITLYLSGAAAPLMTELAGQIGYNIPKDAVEVTSLAVGTQWYTWIVYYGLHWFGGIL
>NZ_MDFD01000015.1|WP_003721293.1|267486_267780_+|PTS-sugar-transporter-subunit-IIB
MKKKRIYVCCGTGIATSTVISKKVRAVLDEKRIPYEISQCTVQEVASKVSTSKPDIIVSSTTVTGDVGDVPVVIGRSFLTGLKKQETIDEILAILQD
>NZ_MDFD01000015.1|WP_012951246.1|266424_267471_+|galactitol-1-phosphate-5-dehydrogenase
MKALKLYGKRDLRYEEADMPTIEEPDDVILKVKTVGICGSDISRYSKLGPYVPGMVWGHEFSGEVIEVGSEVTDIEIGDRAAGCPALYCGECEYCKKGEFARCRKLTVIGARHPGAYAEYIKLPAENVVKIPDELDYEAAALVEPSAVVVHGFYHTKLQAGDDVVVVGSGNIGLLAIQWAKVFGARRVIAIDVDDKKLALAKEVGADVVINSLKEDPLEVVAAHTDGLNADLVVEAAGSPITSAQVFAYAKKGGGVVFLGIPYADVTIERFYFEKIVRSELTVWGSWNAISAPFPGKEWQTTIHFLANKQINIEPMITHRLSLAEGPEVFERIYERNEFFGKILFFPE
>NZ_MDFD01000015.1|WP_012951245.1|265777_266428_+|ribulose-phosphate-3-epimerase
MAKIVPSVFGADIGRINEQLQVLEKNDIDLLHVDMMDGSFVPNIAFGPDQIKMMKKGTKLQFDVHMMVYEPDRYIPRLVEAGAHMITVHQEATTHLHRTIQLIKSYGVRAGVVLNPGTPPSTLEYVLDDIDCILLMTVNPGLGGQKFFQSSLEKIRKTKAYIGNRPIQIEVDGGVNAELAKECTLAGADLIVVGSYLFEGDIEANLEKLAKGVLTE
>NZ_MDFD01000015.1|WP_003721290.1|265368_265767_+|hypothetical-protein
MGSFFASFVDWLIGSPGRFVVNLIEDNMLIFMVVVMIYATTILYAKWTLAYYLPKKMSQLAEMKTWELDELYAAWQTEKKALPWYILVPSRNEFWVKSARNAPESTKLLHFSQQKLKLSDKEKLQKIIEIQS
>NZ_MDFD01000015.1|WP_003733191.1|264884_265352_+|PTS-sugar-transporter-subunit-IIA
MDVLEYFKEEMVRFSNEQNKEKLLAEMAEQLCEVGAVKPSYKDAVIKREKVFPTGLLTAHAGVAIPHTDSEHVIRPVVAVRILKKPVSFIEMASDNEAIDVRIVFMMALRSADEQLDMLQTLIQLIQDEEVMTTLLKAQETGDVLSAIEHFSKNN
>NZ_MDFD01000015.1|WP_012951244.1|264254_264857_+|SIS-domain-containing-protein
MDKQAILNNIHQTWQEEANAISRLPEVTSEEALVKTVEKIAECTGKIVVAGCGTSGVAAKKLVYSFNCIERPAVFLTPSDAVHGTLGVLQKEDILILISKGGNTGELLNLIPACKTKGSTLIGVTENPDSVIAKEADIFFPVSVSKEPDPFNMLATASTMAVIASFDAVIVCLMTYMNYTKEQFSVIHPGGAVGNKLLNK
>NZ_MDFD01000015.1|WP_003733193.1|262190_264251_+|BglG-family-transcription-antiterminator
MYLDNRSKTLFQEVIKNPNITNKQLEVKYKLSRYQISYSFQKVNEWLKWKNYPEVKRSKNGRFILEPELTALFSEKETRDPSVEYLPSENERANLILLMLLTSKEELSLAHFTTKIQVSKNTILRDLKVAQKLLPKETTVTYSRASGYQLAGSEWELRKVLTQVVSSVKEMFRGEHYFLSYSGIEKVQLMEIRRTLEEAEAMMQIKFTYEQIELLPYLLSVMFLRIRDRRLIDTAFHIDEKSLSDTREYHITDILLEKTGPVPEQERLFITLQLLTTNIFSGEILTEKLTEDLEKVVLTCLDLFEKKALVSLKNKHILIEKLLLHLKPAYYRIKYQMNLEDTLYEKFNQEFEALNFIVKEAFDPLAKFIGREIPAGEIFFISLFIGSDMIPQNDIYHKQKRAIVLCPSGVTFSKIMENILVKLFPEIHFYPTISVREYAFFKAEVDIVFSSIPLKDGENVFVVQPFMNDIEKTQLRQHVLQNLFGMGNQLTSIDKIMEVVERNADIKDPNAIRDGIIDILSANTATDENKRVKKVYLHDLITEDNIMICEDVKNYQEAIRLASQPLLLQQAITANYVKTMIDNHKFHDPYIIIGEDIAIPHAMPNAGVNRLAMSLLVVKNGVYFSETEQVHFVIVIAPVDKEQHIEALYQIVHLAENHQILDDLLENVTKEKIMQTINQLVIREDE
>NZ_MDFD01000015.1|WP_012951243.1|261431_262082_+|transaldolase
MHLDSANLDDVKKIQASSIFKGITTNPTILVKEKCNRQTAINRILELTDKQVFVQTVGFTYEEILADARMLLTMFGKDKIAIKIPAHEAGTNVIDTLKKEDKTIQILGTAIYSADQAITAALVGADFVAPYVNRMSAANIDPFKEIRQMRHFFDKKALKTQIMAASFKHSGQVMQAYESGADTVTIPYEIYLQMTNKVLAVEAIRVFNEDAVLYEK
>NZ_MDFD01000015.1|WP_012951247.1|271247_271826_+|hypothetical-protein
MKKILVPILLLATILASCSSPNEKITKDTKISKTNTIRADYKVPKDIKELEDDSANIVKVKFLQNKTIGKDGSTISEIEILTSYKGNLEKGSKVDISEPWYLSDGKYVAVENYIALDKEQEYTIFLGEKDKDTYPLSSLGYGKFGGSLKEDQAVLADFNILGEVQKFDFISENTEEVKNYQLIKEQVAGKYK
>NZ_MDFD01000015.1|WP_003721297.1|271932_272613_+|type-1-glutamine-amidotransferase
MIIDVLQHVPHEGPGLIANWARENQHQLKIHSLFEENAHVPNDSDFLIVLGGPMGINDTAEFPWLKDERKLIKRLSEQHKPVFGVCLGAQQIAATFGSEITVNKEKEVGWFPVKRTSDKLLFFPESLNVFHWHQDTFALPTGSTRLFASEGCLNQAFLYGENIIGLQFHFEMEKAGIETILRIDEAFITPGKYVQSVEVMREKDVPEDNKQMLEAILDYLINPKTI
>NZ_MDFD01000015.1|WP_014601718.1|272637_272997_-|Lin0512-family-protein
MEQILFIQTGFGVDVHGQNITNAAERAVRNAIFTNSMPGIQGLLPDGDLQNMVVNIKLALPCDADQLDEDTIRAIIPYGTVTIEKMAGGMMTTSGIFLEDKEDKNDLMYIVNASVETGY
>NZ_MDFD01000015.1|WP_003733187.1|273003_273462_-|MarR-family-transcriptional-regulator
MNNEQNMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERELLTIEQGRRDKRQRCIFLTAAGKELENELGAAQRKQMSEIFTNSADTDGMHFTEVMEGYAKNRPGAAFIKDFKE
>NZ_MDFD01000015.1|WP_012951250.1|273843_275679_+|lmo0514-family-class-1-internalin
MKKALKLFLATICMFIMIYPSTAAHAEETNIVNIPDANLKTYLNGLLKQASDAPITKTQMNTIQTVTLSGSTYTDLTGLEEAGNLVTLSLNNTNIQTLEPIKNQTSLTYLTVGGDNVKDSLFVDLNGLVNLQSLSISGSEVTHNVFKTFNKLPKLTYLYAQNSMKITDISALASLPALTTLFLQFDGIDDFRPLNDFESFKNGNLKALAAFGQNTGRTNPRITLKSGKLDYNETNQTLYLPFSMMPKPLTSFDGTVAPFSKSTSASNTYLGFNDVALPSSRLSITDDGITVSGVTKEEFDNLDEIEYNARYDFPTGSYPTPPSMTSYTISSGTYDQYFDISHTLDLTADESFDYNQYDTTSEEQFLKDVHAETDDGTAVKSDFDQVVKLDVPGEYTVTLNAENAAGLKATPVTVKVTVHEKPVITSDSQISYKKETTKSVDEFLKEIHGSVTGNAVLTSDFDKVVDLNTPGEYTVTLNAINDRGQKADPVTVVVTVTTSDSGHVDPVPPTPEIKPTPQEETDQTIIPEPQSETTEDSVKEDQAKDGQAKSEEKADKTSLTTKENKVEKSEKTNQPKTKALPQTGDTNKTALPIAGVMLSLAALLIFRKSKS
>NZ_MDFD01000015.1|WP_003721301.1|275779_276211_+|universal-stress-protein
MEKYHRILVAVDGSEPAKLAFEKGLELALKLDGVLGIASIVDLRAFSPNVSYDGSLEEKAELELKTSVNEYAEKARTAGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NZ_MDFD01000015.1|WP_012951251.1|276257_277688_-|CapA-family-protein
MKKLTYVIITGLVLVFIAGAFWITNSTNQSDQKATQTEPIKKISPANVKTISSEAKKTLNSLASSGADKASISDLKQLIKELKSYPTEKNDSGVYLQNLTACLEAVKSYTTGKTDEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTVINAESAFTNATKAENKKWRIKSDPAHVAFLPASGVDAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNADAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDVKKYKKEDTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
>NZ_MDFD01000015.1|WP_003721303.1|277808_278624_-|histidine-phosphatase-family-protein
MKKNIFKLLMALCAVLLIAGCGNSTSADKKETKETKEDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVKSAGKGLKDVDFSAAYSSDSGRAIQTANLILKESDKSADKEVQTDPRFREFNFGSYEGDLNENMWTDIAKSQGKTLEEWQKAGLSPKDFANSVAALDKTRVKEGENWPAEDYATIQARLKEGLTDVAKKESKNGDSNVLLVSHGLSIGALLDTIEPGYKLPAEGIKNASVTKITYKDGKFTIGDVNDLSYVEKGSK
>NZ_MDFD01000015.1|WP_012951252.1|278904_279273_-|DUF1304-domain-containing-protein
MAILAFILTFIVMIEHIYIMILEMFFANTKLAAKTFGVEKELLANKKVQTLFANQGLYNGFLAAGLVWGLFFAGAGMAETVQIFFLSCVVVAALFGGATSSKGILVKQGLPAVLALVAVLLV
>NZ_MDFD01000015.1|WP_003727295.1|279419_280835_+|multidrug-efflux-MFS-transporter
MQQEATGGQKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAALSPTFAMLMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGMKFMQNVSVVTKPKIDILSIILSTLGFGGVVFAFSSAGESGWGSATVLVSIIVGGLALGLFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVVALFFLTRIEVGTSALTIIVLHSVLMIGISMVMMPAQTNGLNQLPPKLYPDGTAIMNTLQQVSGAIGTAVAITIMSAGQKAYMETAQGVGPEQMVASLTAGIQNAFVFGLIMACIGLLCSLFIRKAK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_MDFD01000015_1	1.6\|270728\|36\|NZ_MDFD01000015\|PILER-CR,CRT	270728-270763	36	NZ_MDFD01000023.1	118579-118614	0	1.0
NZ_MDFD01000015_1	1.7\|270793\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270793-270827	35	NZ_MDFD01000003.1	66722-66756	0	1.0

1. spacer 1.6|270728|36|NZ_MDFD01000015|PILER-CR,CRT matches to position: 118579-118614, mismatch: 0, identity: 1.0

aaaataggaggaaataaattatgactatcaaattaa	CRISPR spacer
aaaataggaggaaataaattatgactatcaaattaa	Protospacer
************************************

2. spacer 1.7|270793|35|NZ_MDFD01000015|PILER-CR,CRT matches to position: 66722-66756, mismatch: 0, identity: 1.0

tttgttgaatcaacggatatagattttacaatttc	CRISPR spacer
tttgttgaatcaacggatatagattttacaatttc	Protospacer
***********************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_MDFD01000015_1	1.1\|270408\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270408-270442	35	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	214611-214645	0	1.0
NZ_MDFD01000015_1	1.1\|270408\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270408-270442	35	MT500540	Listeria phage LP-HM00113468, complete genome	39834-39868	0	1.0
NZ_MDFD01000015_1	1.1\|270408\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270408-270442	35	KJ094023	Listeria phage LP-101, complete genome	5084-5118	0	1.0
NZ_MDFD01000015_1	1.6\|270728\|36\|NZ_MDFD01000015\|PILER-CR,CRT	270728-270763	36	MT500540	Listeria phage LP-HM00113468, complete genome	683-718	0	1.0
NZ_MDFD01000015_1	1.6\|270728\|36\|NZ_MDFD01000015\|PILER-CR,CRT	270728-270763	36	NC_009812	Listeria phage B025, complete genome	3896-3931	0	1.0
NZ_MDFD01000015_1	1.6\|270728\|36\|NZ_MDFD01000015\|PILER-CR,CRT	270728-270763	36	KJ094023	Listeria phage LP-101, complete genome	3936-3971	0	1.0
NZ_MDFD01000015_1	1.7\|270793\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270793-270827	35	DQ003642	Listeria phage A006, complete genome	15712-15746	0	1.0
NZ_MDFD01000015_1	1.3\|270537\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270537-270571	35	MH341453	Listeria phage PSU-VKH-LP041, complete genome	10139-10173	1	0.971
NZ_MDFD01000015_1	1.5\|270664\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270664-270698	35	NC_021539	Listeria phage LP-030-2, complete genome	18926-18960	1	0.971
NZ_MDFD01000015_1	1.5\|270664\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270664-270698	35	KJ094023	Listeria phage LP-101, complete genome	22882-22916	1	0.971
NZ_MDFD01000015_1	1.6\|270728\|36\|NZ_MDFD01000015\|PILER-CR,CRT	270728-270763	36	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	213463-213498	1	0.972
NZ_MDFD01000015_1	1.8\|270408\|36\|NZ_MDFD01000015\|CRISPRCasFinder	270408-270443	36	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	214611-214646	1	0.972
NZ_MDFD01000015_1	1.8\|270408\|36\|NZ_MDFD01000015\|CRISPRCasFinder	270408-270443	36	MT500540	Listeria phage LP-HM00113468, complete genome	39833-39868	1	0.972
NZ_MDFD01000015_1	1.8\|270408\|36\|NZ_MDFD01000015\|CRISPRCasFinder	270408-270443	36	KJ094023	Listeria phage LP-101, complete genome	5084-5119	1	0.972
NZ_MDFD01000015_1	1.10\|270537\|36\|NZ_MDFD01000015\|CRISPRCasFinder	270537-270572	36	MH341453	Listeria phage PSU-VKH-LP041, complete genome	10139-10174	1	0.972
NZ_MDFD01000015_1	1.12\|270664\|36\|NZ_MDFD01000015\|CRISPRCasFinder	270664-270699	36	NC_021539	Listeria phage LP-030-2, complete genome	18926-18961	1	0.972
NZ_MDFD01000015_1	1.12\|270664\|36\|NZ_MDFD01000015\|CRISPRCasFinder	270664-270699	36	KJ094023	Listeria phage LP-101, complete genome	22882-22917	1	0.972
NZ_MDFD01000015_1	1.13\|270728\|37\|NZ_MDFD01000015\|CRISPRCasFinder	270728-270764	37	MT500540	Listeria phage LP-HM00113468, complete genome	682-718	1	0.973
NZ_MDFD01000015_1	1.13\|270728\|37\|NZ_MDFD01000015\|CRISPRCasFinder	270728-270764	37	NC_009812	Listeria phage B025, complete genome	3896-3932	1	0.973
NZ_MDFD01000015_1	1.13\|270728\|37\|NZ_MDFD01000015\|CRISPRCasFinder	270728-270764	37	KJ094023	Listeria phage LP-101, complete genome	3936-3972	1	0.973
NZ_MDFD01000015_1	1.14\|270793\|36\|NZ_MDFD01000015\|CRISPRCasFinder	270793-270828	36	DQ003642	Listeria phage A006, complete genome	15711-15746	1	0.972
NZ_MDFD01000015_1	1.1\|270408\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270408-270442	35	NC_009812	Listeria phage B025, complete genome	5044-5078	2	0.943
NZ_MDFD01000015_1	1.3\|270537\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270537-270571	35	NC_009813	Listeria phage B054, complete genome	10139-10173	2	0.943
NZ_MDFD01000015_1	1.5\|270664\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270664-270698	35	NC_009812	Listeria phage B025, complete genome	23381-23415	2	0.943
NZ_MDFD01000015_1	1.10\|270537\|36\|NZ_MDFD01000015\|CRISPRCasFinder	270537-270572	36	NC_009813	Listeria phage B054, complete genome	10139-10174	2	0.944
NZ_MDFD01000015_1	1.12\|270664\|36\|NZ_MDFD01000015\|CRISPRCasFinder	270664-270699	36	NC_009812	Listeria phage B025, complete genome	23381-23416	2	0.944
NZ_MDFD01000015_1	1.13\|270728\|37\|NZ_MDFD01000015\|CRISPRCasFinder	270728-270764	37	NZ_LR134403	Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence	213463-213499	2	0.946
NZ_MDFD01000015_1	1.8\|270408\|36\|NZ_MDFD01000015\|CRISPRCasFinder	270408-270443	36	NC_009812	Listeria phage B025, complete genome	5044-5079	3	0.917
NZ_MDFD01000015_1	1.6\|270728\|36\|NZ_MDFD01000015\|PILER-CR,CRT	270728-270763	36	JN700520	Staphylococcus phage StB12, complete genome	6832-6867	5	0.861
NZ_MDFD01000015_1	1.13\|270728\|37\|NZ_MDFD01000015\|CRISPRCasFinder	270728-270764	37	JN700520	Staphylococcus phage StB12, complete genome	6832-6868	6	0.838
NZ_MDFD01000015_1	1.6\|270728\|36\|NZ_MDFD01000015\|PILER-CR,CRT	270728-270763	36	MW084976	Bacillus phage Kirov, complete genome	27565-27600	8	0.778
NZ_MDFD01000015_1	1.13\|270728\|37\|NZ_MDFD01000015\|CRISPRCasFinder	270728-270764	37	MW084976	Bacillus phage Kirov, complete genome	27565-27601	9	0.757
NZ_MDFD01000015_1	1.7\|270793\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270793-270827	35	NZ_CP029455	Bacillus cereus strain FORC087 plasmid pFORC087.1, complete sequence	130632-130666	11	0.686
NZ_MDFD01000015_1	1.7\|270793\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270793-270827	35	NZ_CP015592	Bacillus cereus strain AR156 plasmid pAR460, complete sequence	17622-17656	11	0.686
NZ_MDFD01000015_1	1.7\|270793\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270793-270827	35	NZ_CP009368	Bacillus cereus strain FM1 plasmid unnamed, complete sequence	31860-31894	11	0.686
NZ_MDFD01000015_1	1.7\|270793\|35\|NZ_MDFD01000015\|PILER-CR,CRT	270793-270827	35	NZ_CP009336	Bacillus thuringiensis strain HD1011 plasmid 1, complete sequence	338888-338922	11	0.686

1. spacer 1.1|270408|35|NZ_MDFD01000015|PILER-CR,CRT matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 0, identity: 1.0

acagatcaaactccggaagggtgattgtaaatggc	CRISPR spacer
acagatcaaactccggaagggtgattgtaaatggc	Protospacer
***********************************

2. spacer 1.1|270408|35|NZ_MDFD01000015|PILER-CR,CRT matches to MT500540 (Listeria phage LP-HM00113468, complete genome) position: , mismatch: 0, identity: 1.0

acagatcaaactccggaagggtgattgtaaatggc	CRISPR spacer
acagatcaaactccggaagggtgattgtaaatggc	Protospacer
***********************************

3. spacer 1.1|270408|35|NZ_MDFD01000015|PILER-CR,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 0, identity: 1.0

acagatcaaactccggaagggtgattgtaaatggc	CRISPR spacer
acagatcaaactccggaagggtgattgtaaatggc	Protospacer
***********************************

4. spacer 1.6|270728|36|NZ_MDFD01000015|PILER-CR,CRT matches to MT500540 (Listeria phage LP-HM00113468, complete genome) position: , mismatch: 0, identity: 1.0

aaaataggaggaaataaattatgactatcaaattaa	CRISPR spacer
aaaataggaggaaataaattatgactatcaaattaa	Protospacer
************************************

5. spacer 1.6|270728|36|NZ_MDFD01000015|PILER-CR,CRT matches to NC_009812 (Listeria phage B025, complete genome) position: , mismatch: 0, identity: 1.0

aaaataggaggaaataaattatgactatcaaattaa	CRISPR spacer
aaaataggaggaaataaattatgactatcaaattaa	Protospacer
************************************

6. spacer 1.6|270728|36|NZ_MDFD01000015|PILER-CR,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 0, identity: 1.0

aaaataggaggaaataaattatgactatcaaattaa	CRISPR spacer
aaaataggaggaaataaattatgactatcaaattaa	Protospacer
************************************

7. spacer 1.7|270793|35|NZ_MDFD01000015|PILER-CR,CRT matches to DQ003642 (Listeria phage A006, complete genome) position: , mismatch: 0, identity: 1.0

tttgttgaatcaacggatatagattttacaatttc	CRISPR spacer
tttgttgaatcaacggatatagattttacaatttc	Protospacer
***********************************

8. spacer 1.3|270537|35|NZ_MDFD01000015|PILER-CR,CRT matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 1, identity: 0.971

gcgatttttgtcaaagggacagcgatgggttacaa	CRISPR spacer
gcgatttttgtcaaaggaacagcgatgggttacaa	Protospacer
*****************.*****************

9. spacer 1.5|270664|35|NZ_MDFD01000015|PILER-CR,CRT matches to NC_021539 (Listeria phage LP-030-2, complete genome) position: , mismatch: 1, identity: 0.971

ctaaaacatccttcactgtatcaactcctttctat	CRISPR spacer
ctaaaacatccttcactgtctcaactcctttctat	Protospacer
******************* ***************

10. spacer 1.5|270664|35|NZ_MDFD01000015|PILER-CR,CRT matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 1, identity: 0.971

ctaaaacatccttcactgtatcaactcctttctat	CRISPR spacer
ctaaaacatccttcactgtctcaactcctttctat	Protospacer
******************* ***************

11. spacer 1.6|270728|36|NZ_MDFD01000015|PILER-CR,CRT matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 1, identity: 0.972

aaaataggaggaaataaattatgactatcaaattaa	CRISPR spacer
aaaataggaggaaatagattatgactatcaaattaa	Protospacer
****************.*******************

12. spacer 1.8|270408|36|NZ_MDFD01000015|CRISPRCasFinder matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 1, identity: 0.972

acagatcaaactccggaagggtgattgtaaatggcg	CRISPR spacer
acagatcaaactccggaagggtgattgtaaatggct	Protospacer
***********************************

13. spacer 1.8|270408|36|NZ_MDFD01000015|CRISPRCasFinder matches to MT500540 (Listeria phage LP-HM00113468, complete genome) position: , mismatch: 1, identity: 0.972

acagatcaaactccggaagggtgattgtaaatggcg	CRISPR spacer
acagatcaaactccggaagggtgattgtaaatggct	Protospacer
***********************************

14. spacer 1.8|270408|36|NZ_MDFD01000015|CRISPRCasFinder matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 1, identity: 0.972

acagatcaaactccggaagggtgattgtaaatggcg	CRISPR spacer
acagatcaaactccggaagggtgattgtaaatggct	Protospacer
***********************************

15. spacer 1.10|270537|36|NZ_MDFD01000015|CRISPRCasFinder matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 1, identity: 0.972

gcgatttttgtcaaagggacagcgatgggttacaag	CRISPR spacer
gcgatttttgtcaaaggaacagcgatgggttacaag	Protospacer
*****************.******************

16. spacer 1.12|270664|36|NZ_MDFD01000015|CRISPRCasFinder matches to NC_021539 (Listeria phage LP-030-2, complete genome) position: , mismatch: 1, identity: 0.972

ctaaaacatccttcactgtatcaactcctttctata	CRISPR spacer
ctaaaacatccttcactgtctcaactcctttctata	Protospacer
******************* ****************

17. spacer 1.12|270664|36|NZ_MDFD01000015|CRISPRCasFinder matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 1, identity: 0.972

ctaaaacatccttcactgtatcaactcctttctata	CRISPR spacer
ctaaaacatccttcactgtctcaactcctttctata	Protospacer
******************* ****************

18. spacer 1.13|270728|37|NZ_MDFD01000015|CRISPRCasFinder matches to MT500540 (Listeria phage LP-HM00113468, complete genome) position: , mismatch: 1, identity: 0.973

aaaataggaggaaataaattatgactatcaaattaag	CRISPR spacer
aaaataggaggaaataaattatgactatcaaattaaa	Protospacer
************************************.

19. spacer 1.13|270728|37|NZ_MDFD01000015|CRISPRCasFinder matches to NC_009812 (Listeria phage B025, complete genome) position: , mismatch: 1, identity: 0.973

aaaataggaggaaataaattatgactatcaaattaag	CRISPR spacer
aaaataggaggaaataaattatgactatcaaattaaa	Protospacer
************************************.

20. spacer 1.13|270728|37|NZ_MDFD01000015|CRISPRCasFinder matches to KJ094023 (Listeria phage LP-101, complete genome) position: , mismatch: 1, identity: 0.973

aaaataggaggaaataaattatgactatcaaattaag	CRISPR spacer
aaaataggaggaaataaattatgactatcaaattaaa	Protospacer
************************************.

21. spacer 1.14|270793|36|NZ_MDFD01000015|CRISPRCasFinder matches to DQ003642 (Listeria phage A006, complete genome) position: , mismatch: 1, identity: 0.972

tttgttgaatcaacggatatagattttacaatttcg	CRISPR spacer
tttgttgaatcaacggatatagattttacaatttct	Protospacer
***********************************

22. spacer 1.1|270408|35|NZ_MDFD01000015|PILER-CR,CRT matches to NC_009812 (Listeria phage B025, complete genome) position: , mismatch: 2, identity: 0.943

acagatcaaactccggaagggtgattgtaaatggc	CRISPR spacer
gcagaacaaactccggaagggtgattgtaaatggc	Protospacer
.**** *****************************

23. spacer 1.3|270537|35|NZ_MDFD01000015|PILER-CR,CRT matches to NC_009813 (Listeria phage B054, complete genome) position: , mismatch: 2, identity: 0.943

gcgatttttgtcaaagggacagcgatgggttacaa	CRISPR spacer
gcgatttttgtcaaaggaacggcgatgggttacaa	Protospacer
*****************.**.**************

24. spacer 1.5|270664|35|NZ_MDFD01000015|PILER-CR,CRT matches to NC_009812 (Listeria phage B025, complete genome) position: , mismatch: 2, identity: 0.943

ctaaaacatccttcactgtatcaactcctttctat	CRISPR spacer
ctaaaacatccttcactatctcaactcctttctat	Protospacer
*****************.* ***************

25. spacer 1.10|270537|36|NZ_MDFD01000015|CRISPRCasFinder matches to NC_009813 (Listeria phage B054, complete genome) position: , mismatch: 2, identity: 0.944

gcgatttttgtcaaagggacagcgatgggttacaag	CRISPR spacer
gcgatttttgtcaaaggaacggcgatgggttacaag	Protospacer
*****************.**.***************

26. spacer 1.12|270664|36|NZ_MDFD01000015|CRISPRCasFinder matches to NC_009812 (Listeria phage B025, complete genome) position: , mismatch: 2, identity: 0.944

ctaaaacatccttcactgtatcaactcctttctata	CRISPR spacer
ctaaaacatccttcactatctcaactcctttctata	Protospacer
*****************.* ****************

27. spacer 1.13|270728|37|NZ_MDFD01000015|CRISPRCasFinder matches to NZ_LR134403 (Listeria monocytogenes strain NCTC7974 plasmid 6, complete sequence) position: , mismatch: 2, identity: 0.946

aaaataggaggaaataaattatgactatcaaattaag	CRISPR spacer
aaaataggaggaaatagattatgactatcaaattaaa	Protospacer
****************.*******************.

28. spacer 1.8|270408|36|NZ_MDFD01000015|CRISPRCasFinder matches to NC_009812 (Listeria phage B025, complete genome) position: , mismatch: 3, identity: 0.917

acagatcaaactccggaagggtgattgtaaatggcg	CRISPR spacer
gcagaacaaactccggaagggtgattgtaaatggct	Protospacer
.**** *****************************

29. spacer 1.6|270728|36|NZ_MDFD01000015|PILER-CR,CRT matches to JN700520 (Staphylococcus phage StB12, complete genome) position: , mismatch: 5, identity: 0.861

aaaataggaggaaataaattatgact-atcaaattaa	CRISPR spacer
taaataggaggaagtaaataatgactaatcaaacta-	Protospacer
 ************.***** ****** ******.**

30. spacer 1.13|270728|37|NZ_MDFD01000015|CRISPRCasFinder matches to JN700520 (Staphylococcus phage StB12, complete genome) position: , mismatch: 6, identity: 0.838

aaaataggaggaaataaattatgact-atcaaattaag	CRISPR spacer
taaataggaggaagtaaataatgactaatcaaactat-	Protospacer
 ************.***** ****** ******.**

31. spacer 1.6|270728|36|NZ_MDFD01000015|PILER-CR,CRT matches to MW084976 (Bacillus phage Kirov, complete genome) position: , mismatch: 8, identity: 0.778

aaaataggaggaaataaattatgactatcaaattaa	CRISPR spacer
ttaataggaggaaataaataatggctatcgtaagaa	Protospacer
  ***************** ***.*****. *  **

32. spacer 1.13|270728|37|NZ_MDFD01000015|CRISPRCasFinder matches to MW084976 (Bacillus phage Kirov, complete genome) position: , mismatch: 9, identity: 0.757

aaaataggaggaaataaattatgactatcaaattaag	CRISPR spacer
ttaataggaggaaataaataatggctatcgtaagaaa	Protospacer
  ***************** ***.*****. *  **.

33. spacer 1.7|270793|35|NZ_MDFD01000015|PILER-CR,CRT matches to NZ_CP029455 (Bacillus cereus strain FORC087 plasmid pFORC087.1, complete sequence) position: , mismatch: 11, identity: 0.686

tttgttgaatcaacggatatagattttacaatttc	CRISPR spacer
agaaaaaaatcaaccgatatagattttaaaatctt	Protospacer
   .  .******* ************* ***.*.

34. spacer 1.7|270793|35|NZ_MDFD01000015|PILER-CR,CRT matches to NZ_CP015592 (Bacillus cereus strain AR156 plasmid pAR460, complete sequence) position: , mismatch: 11, identity: 0.686

tttgttgaatcaacggatatagattttacaatttc	CRISPR spacer
aagaaaaaatcaaccgatatagattttaaaatctt	Protospacer
   .  .******* ************* ***.*.

35. spacer 1.7|270793|35|NZ_MDFD01000015|PILER-CR,CRT matches to NZ_CP009368 (Bacillus cereus strain FM1 plasmid unnamed, complete sequence) position: , mismatch: 11, identity: 0.686

tttgttgaatcaacggatatagattttacaatttc	CRISPR spacer
agaaaaaaatcaaccgatatagattttaaaatctt	Protospacer
   .  .******* ************* ***.*.

36. spacer 1.7|270793|35|NZ_MDFD01000015|PILER-CR,CRT matches to NZ_CP009336 (Bacillus thuringiensis strain HD1011 plasmid 1, complete sequence) position: , mismatch: 11, identity: 0.686

tttgttgaatcaacggatatagattttacaatttc	CRISPR spacer
agaaaaaaatcaaccgatatagattttaaaatctt	Protospacer
   .  .******* ************* ***.*.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

412282 : 442249

Listeria_phage(42.86%)

protease,head,integrase,capsid,portal,terminase,tail

attL 405148:405162|attR 425928:425942

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
405148:405162	attL	NA	NA	NA	NA
WP_023552234.1\|412282_413434_-\|integrase	site-specific integrase	A8ATX2	Listeria_phage	3.4e-87	46.3
WP_023552237.1\|413455_414169_-	hypothetical protein	A0A0B5CTT6	Listeria_phage	1.1e-35	36.1
WP_014930667.1\|414223_414724_-	hypothetical protein	A0A1S7FYX8	Listeria_phage	1.9e-13	31.9
WP_012951299.1\|414736_415063_-	helix-turn-helix transcriptional regulator	A0A2H4J6F9	uncultured_Caudovirales_phage	2.5e-11	35.1
WP_023552239.1\|415236_415428_+	helix-turn-helix transcriptional regulator	Q0H243	Geobacillus_phage	4.7e-10	57.6
WP_012951301.1\|415525_415852_+	DUF771 domain-containing protein	A0A2H4J474	uncultured_Caudovirales_phage	4.9e-15	41.1
WP_023552243.1\|416024_416939_+	conserved phage C-terminal domain-containing protein	A0A1W6JNI1	Staphylococcus_phage	7.8e-58	51.5
WP_023552245.1\|416940_417297_+	hypothetical protein	NA	NA	NA	NA
WP_023552247.1\|417293_417710_+	hypothetical protein	NA	NA	NA	NA
WP_023552249.1\|417706_417883_+	hypothetical protein	A8ATL8	Listeria_phage	1.7e-14	70.7
WP_023552251.1\|417897_418617_+	DUF2786 domain-containing protein	A0A1U9WR73	Streptococcus_virus	3.5e-21	29.7
WP_023552253.1\|418620_418923_+	hypothetical protein	A0A059T695	Listeria_phage	3.8e-22	96.2
WP_023552255.1\|418919_419321_+	hypothetical protein	A8ASP1	Listeria_phage	3.2e-40	58.8
WP_023552257.1\|419320_420031_+	hypothetical protein	NA	NA	NA	NA
WP_023552259.1\|420043_420232_+	hypothetical protein	NA	NA	NA	NA
WP_023552261.1\|420228_420690_+	hypothetical protein	A0A0C5K8Z3	Enterococcus_phage	2.0e-09	34.2
WP_023552263.1\|420686_421070_+	hypothetical protein	A8ATZ3	Listeria_phage	5.4e-45	77.2
WP_023552266.1\|421090_421339_+	DUF3850 domain-containing protein	A0A059T7N3	Listeria_phage	5.0e-28	84.0
WP_023552268.1\|421338_421920_+	DUF3310 domain-containing protein	A0A059T5J6	Listeria_phage	2.3e-76	76.3
WP_023552271.1\|421919_422399_+	single-stranded DNA-binding protein	A8ASP5	Listeria_phage	1.3e-69	83.8
WP_023552274.1\|422419_422659_+	hypothetical protein	NA	NA	NA	NA
WP_031694735.1\|422649_422835_+	hypothetical protein	NA	NA	NA	NA
WP_023552279.1\|422905_423424_+	hypothetical protein	NA	NA	NA	NA
WP_023552281.1\|423420_423963_+\|integrase	tyrosine-type recombinase/integrase	H0USV4	Bacillus_phage	2.5e-48	53.3
WP_023552283.1\|423978_424311_+	hypothetical protein	NA	NA	NA	NA
WP_023552285.1\|424581_424908_+	hypothetical protein	NA	NA	NA	NA
WP_023552287.1\|424904_425267_+	HNH endonuclease	A0A075M5R4	Enterococcus_phage	5.5e-15	46.2
WP_012951321.1\|425361_425889_+\|terminase	phage terminase small subunit P27 family	J7KC46	Streptococcus_phage	6.1e-31	46.7
WP_012951322.1\|425857_427609_+\|terminase	terminase large subunit	A0A2H4JCI4	uncultured_Caudovirales_phage	4.1e-156	50.7
425928:425942	attR	NA	NA	NA	NA
WP_023552290.1\|427615_427816_+	DUF1056 family protein	NA	NA	NA	NA
WP_012951323.1\|427818_429054_+\|portal	phage portal protein	A0A2H4JAR2	uncultured_Caudovirales_phage	3.6e-82	42.1
WP_012951324.1\|429050_429617_+\|head,protease	HK97 family phage prohead protease	A0A1D6Z2A7	Staphylococcus_phage	1.0e-44	52.2
WP_012951325.1\|429680_430850_+\|capsid	phage major capsid protein	A0A060AI54	Enterococcus_phage	2.1e-44	38.1
WP_023552291.1\|430898_431237_+\|head,tail	phage gp6-like head-tail connector protein	NA	NA	NA	NA
WP_012951327.1\|431206_431527_+\|head	phage head closure protein	NA	NA	NA	NA
WP_012951328.1\|431520_431886_+	HK97 gp10 family phage protein	B4XYP9	Lactobacillus_phage	2.4e-10	37.4
WP_012951329.1\|431888_432287_+	hypothetical protein	NA	NA	NA	NA
WP_012951330.1\|432307_432883_+\|tail	major tail protein	M1PRQ7	Streptococcus_phage	1.2e-32	42.4
WP_012951331.1\|432972_433320_+	hypothetical protein	NA	NA	NA	NA
WP_068995373.1\|433516_437716_+\|tail	phage tail tape measure protein	J7KDT4	Streptococcus_phage	1.2e-12	33.0
WP_069002698.1\|437708_439952_+\|tail	phage tail family protein	A0A059T682	Listeria_phage	4.7e-56	29.2
WP_069002699.1\|439957_442249_+\|tail	phage tail protein	A0A059T7Y6	Listeria_phage	7.5e-134	37.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

9. NZ_MDFD01000018

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

268501 : 278054

Hokovirus(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003721506.1\|268501_268885_+	glycerol-3-phosphate cytidylyltransferase	A0A1V0SGE7	Hokovirus	1.4e-16	40.7
WP_003732709.1\|268906_269890_+	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	4.1e-12	34.6
WP_010989660.1\|269904_270918_+	glycosyltransferase	A0A1V0SAH6	Catovirus	7.9e-11	32.0
WP_003721509.1\|271126_272617_+	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	9.5e-114	49.7
WP_003727000.1\|272628_273453_+	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	9.7e-68	52.6
WP_012951453.1\|273465_273774_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_003730540.1\|273833_274238_+	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_012951454.1\|274366_275923_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	3.0e-17	28.1
WP_012951455.1\|276140_278054_+	site-specific DNA-methyltransferase	A0A2K5B2C1	Erysipelothrix_phage	1.3e-59	36.9

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

10. NZ_MDFD01000004

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_MDFD01000004_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_MDFD01000004_1

26667-26818

Unclear

Consensus_repeat	Method
GAGCTCGGTTCCGATGTAGCAGGAGCATTAAAACCAAGAAGCATTGG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_MDFD01000004_1

>merge|NZ_MDFD01000004|1|26667-26818|CRISPRCasFinder
GAGCTCGGTTCCGATGTAGCAGGAGCATTAAAACCAAGAAGCATTGGCGTCTCTGGCAAAGCAAGTCTTAACTCTTCATCCGTAGGTGGTGGTGGAAATTCGAATGAGCTCGGTTCTGATGTAGCAGGAGCATTAAAACCAAGAAGCATTGG

>NZ_MDFD01000004|1|1|26667-26818|CRISPRCasFinder
GAGCTCGGTTCCGATGTAGCAGGAGCATTAAAACCAAGAAGCATTGG	CGTCTCTGGCAAAGCAAGTCTTAACTCTTCATCCGTAGGTGGTGGTGGAAATTCGAAT
GAGCTCGGTTCTGATGTAGCAGGAGCATTAAAACCAAGAAGCATTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_MDFD01000004.1\|WP_003722735.1\|24441_24765_-\|DUF5502-family-protein	unknown	unknown	gnl\|CDD\|340321
NZ_MDFD01000004.1\|WP_012952055.1\|27859_29392_-\|zinc-metalloproteinase-Mpl	unknown	unknown	gnl\|CDD\|225768
NZ_MDFD01000004.1\|WP_012952056.1\|31553_32507_+\|phosphatidylinositol-specific-phospholipase-C	unknown	unknown	gnl\|CDD\|176497
NZ_MDFD01000004.1\|WP_012952052.1\|23845_24307_-\|YehR-family-lipoprotein	unknown	unknown	gnl\|CDD\|227145
NZ_MDFD01000004.1\|WP_003722726.1\|36300_36609_-\|septation-regulator-SpoVG	unknown	unknown	gnl\|CDD\|237321
NZ_MDFD01000004.1\|WP_003722742.1\|19445_20006_-\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_MDFD01000004.1\|WP_003722728.1\|33533_34490_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_MDFD01000004.1\|WP_009930499.1\|22721_23396_+\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|378033
NZ_MDFD01000004.1\|WP_003722731.1\|29722_31312_-\|cholesterol-dependent-cytolysin-listeriolysin-O	unknown	unknown	gnl\|CDD\|366559
NZ_MDFD01000004.1\|WP_003725735.1\|23462_23795_+\|putative-heavy-metal-binding-protein	unknown	unknown	gnl\|CDD\|179228
NZ_MDFD01000004.1\|WP_012952051.1\|20112_20697_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_MDFD01000004.1\|WP_012952053.1\|24836_25706_-\|phosphatidylcholine-phospholipase-C	unknown	unknown	gnl\|CDD\|214813
NZ_MDFD01000004.1\|WP_003722727.1\|34540_35914_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184643
NZ_MDFD01000004.1\|WP_003722729.1\|32777_33491_+\|listeriolysin-O-transcriptional-regulator-PrfA	unknown	unknown	gnl\|CDD\|223736
NZ_MDFD01000004.1\|WP_010989376.1\|15791_19331_-\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NZ_MDFD01000004.1\|WP_009931069.1\|37721_38930_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182528
NZ_MDFD01000004.1\|WP_003722723.1\|38926_39619_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_MDFD01000004.1\|WP_003722725.1\|36728_37037_-\|septation-regulator-SpoVG	unknown	unknown	gnl\|CDD\|237321
NZ_MDFD01000004.1\|WP_003722739.1\|21703_22645_+\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|178836
NZ_MDFD01000004.1\|WP_003722740.1\|20786_21410_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534

Protein	Function_ID	Function_description	E-value
NZ_MDFD01000004.1\|WP_003722735.1\|24441_24765_-\|DUF5502-family-protein	gnl\|CDD\|340321	pfam17606, DUF5502, Family of unknown function (DUF5502). This is a family of unknown function found in Listeria.	5.76244e-49
NZ_MDFD01000004.1\|WP_012952055.1\|27859_29392_-\|zinc-metalloproteinase-Mpl	gnl\|CDD\|225768	COG3227, LasB, Zinc metalloprotease (elastase) [Amino acid transport and metabolism].	9.42667e-139
NZ_MDFD01000004.1\|WP_012952056.1\|31553_32507_+\|phosphatidylinositol-specific-phospholipase-C	gnl\|CDD\|176497	cd00137, PI-PLCc, Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C. This subfamily corresponds to the catalytic domain present in prokaryotic and eukaryotic phosphoinositide-specific phospholipase C (PI-PLC), which is a ubiquitous enzyme catalyzing the cleavage of the sn3-phosphodiester bond in the membrane phosphoinositides (phosphatidylinositol, PI; Phosphatidylinositol-4-phosphate, PIP; phosphatidylinositol 4,5-bisphosphate, PIP2) to yield inositol phosphates (inositol monosphosphate, InsP; inositol diphosphate, InsP2; inositol trisphosphate, InsP3) and diacylglycerol (DAG). The higher eukaryotic PI-PLCs (EC 3.1.4.11) have a multidomain organization that consists of a PLC catalytic core domain, and various regulatory domains. They play a critical role in most signal transduction pathways, controlling numerous cellular events, such as cell growth, proliferation, excitation and secretion. These PI-PLCs strictly require Ca2+ for their catalytic activity. They display a clear preference towards the hydrolysis of the more highly phosphorylated PI-analogues, PIP2 and PIP, to generate two important second messengers, InsP3 and DAG. InsP3 triggers inflow of calcium from intracellular stores, while DAG, together with calcium, activates protein kinase C, which then phosphorylates other molecules, leading to altered cellular activity. In contrast, bacterial PI-PLCs contain a single catalytic domain. Although their precise physiological function remains unclear, bacterial PI-PLCs may function as virulence factors in some pathogenic bacteria. They participate in Ca2+-independent PI metabolism. They are characterized as phosphatidylinositol-specific phospholipase C (EC 4.6.1.13) that selectively hydrolyze PI, not PIP or PIP2. The TIM-barrel type catalytic domain in bacterial PI-PLCs is very similar to the one in eukaryotic PI-PLCs, in which the catalytic domain is assembled from two highly conserved X- and Y-regions split by a divergent linker sequence. The catalytic mechanism of both prokaryotic and eukaryotic PI-PLCs is based on general base and acid catalysis utilizing two well conserved histidines, and consists of two steps, a phosphotransfer and a phosphodiesterase reaction. This superfamily also includes a distinctly different type of eukaryotic PLC, glycosylphosphatidylinositol-specific phospholipase C (GPI-PLC), an integral membrane protein characterized in the protozoan parasite Trypanosoma brucei. T. brucei GPI-PLC hydrolyzes the GPI-anchor on the variant specific glycoprotein (VSG), releasing dimyristyl glycerol (DMG), which may facilitate the evasion of the protozoan to the host#s immune system. It does not require Ca2+ for its activity and is more closely related to bacterial PI-PLCs, but not mammalian PI-PLCs.	6.12448e-116
NZ_MDFD01000004.1\|WP_012952052.1\|23845_24307_-\|YehR-family-lipoprotein	gnl\|CDD\|227145	COG4808, COG4808, Uncharacterized protein conserved in bacteria [Function unknown].	1.58576e-57
NZ_MDFD01000004.1\|WP_003722726.1\|36300_36609_-\|septation-regulator-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	5.03804e-54
NZ_MDFD01000004.1\|WP_003722742.1\|19445_20006_-\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	4.98809e-109
NZ_MDFD01000004.1\|WP_003722728.1\|33533_34490_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0
NZ_MDFD01000004.1\|WP_009930499.1\|22721_23396_+\|DNA-alkylation-repair-protein	gnl\|CDD\|378033	pfam08713, DNA_alkylation, DNA alkylation repair enzyme. Proteins in this family are predicted to be DNA alkylation repair enzymes. The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.	1.81561e-21
NZ_MDFD01000004.1\|WP_003722731.1\|29722_31312_-\|cholesterol-dependent-cytolysin-listeriolysin-O	gnl\|CDD\|366559	pfam01289, Thiol_cytolysin, Thiol-activated cytolysin.	1.50399e-178
NZ_MDFD01000004.1\|WP_003725735.1\|23462_23795_+\|putative-heavy-metal-binding-protein	gnl\|CDD\|179228	PRK01119, PRK01119, putative heavy metal-binding protein.	8.98192e-61
NZ_MDFD01000004.1\|WP_012952051.1\|20112_20697_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	9.33654e-10
NZ_MDFD01000004.1\|WP_012952053.1\|24836_25706_-\|phosphatidylcholine-phospholipase-C	gnl\|CDD\|214813	smart00770, Zn_dep_PLPC, Zinc dependent phospholipase C (alpha toxin). This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.	7.07052e-87
NZ_MDFD01000004.1\|WP_003722727.1\|34540_35914_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184643	PRK14354, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NZ_MDFD01000004.1\|WP_003722729.1\|32777_33491_+\|listeriolysin-O-transcriptional-regulator-PrfA	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	9.59942e-12
NZ_MDFD01000004.1\|WP_010989376.1\|15791_19331_-\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NZ_MDFD01000004.1\|WP_009931069.1\|37721_38930_-\|ABC-transporter-permease	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	2.47504e-62
NZ_MDFD01000004.1\|WP_003722723.1\|38926_39619_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	7.27113e-121
NZ_MDFD01000004.1\|WP_003722725.1\|36728_37037_-\|septation-regulator-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	2.92652e-53
NZ_MDFD01000004.1\|WP_003722739.1\|21703_22645_+\|L-lactate-dehydrogenase	gnl\|CDD\|178836	PRK00066, ldh, L-lactate dehydrogenase; Reviewed.	0
NZ_MDFD01000004.1\|WP_003722740.1\|20786_21410_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	2.38585e-63

>NZ_MDFD01000004.1|WP_012952053.1|24836_25706_-|phosphatidylcholine-phospholipase-C
MKFKKVVLGMCLTASVLVFPVTIKANACCDEYLQTPAAPHDIDSKLPHKLSWSADNPTNTDVNTHYWLFKQAEKILAKDVNHMRANLMNELKKFDKQIAQGIYDADHKNPYYDTSTFLSHFYNPDRDNTYLPGFANAKITGAKYFNQSVTDYREGKFDTAFYKLGLAIHYYTDISQPMHANNFTAISYPPGYHCAYENYVDTIKHNYQATEDMVAKRFCSDDVKDWLYENAKRAKADYPKIVNAKTKKSYLVGNSEWKKDTVKPTGARLRDSQQTLAGFLEFWSKKTNE
>NZ_MDFD01000004.1|WP_003722735.1|24441_24765_-|DUF5502-family-protein
MYIKGRLIFFFVMFVIALCSVLILLIIKISVWKDEPFHLSDAKEIECLGSCEIKNTNQKIHFFSIKENLFEEKGDIAGILNEDEQKVADKSIFIVILDDEKGIANEE
>NZ_MDFD01000004.1|WP_012952052.1|23845_24307_-|YehR-family-lipoprotein
MKMLKKGTAVLFVMIMAVMLVACGDKEETKTYTLSQKGVDSKLTYTYKGDKVTKQTAENTMSYASLGVASKEDAEKMLKATSDKFQGIDGLKEKIEYKDDKAIETLEVDYTKISSEDMNKIPGMSSNGDTSKGISMEESAKMLESQGYKEVSK
>NZ_MDFD01000004.1|WP_003725735.1|23462_23795_+|putative-heavy-metal-binding-protein
MIVTTSPNIEGKQIIEYKKIVFGEVITGVNFMKDIGAGLRNFFGGRSQGYEDELINAREEAIREMEQRAKDIGANAVIGVDIDYEVLGADNGMLMVTASGTAVVIEAQDY
>NZ_MDFD01000004.1|WP_009930499.1|22721_23396_+|DNA-alkylation-repair-protein
MITFDQLDTELQALENPNTIKIFRNHGCPDSLDLYGLKIGDLKKIIRREKLTKNHELAVKLIESNNSDLIYLGLLAINPNKITTEQIEKWNIAFRETWSQLTFGLASIVSKRDDALLFAKTWIESDYDLTKSMGWQIYSEHINNLPEAETLLQRAKETLQTETNRTRYSMNGFIITCGIYKDDLHEKAMEAAKSVGKVHVNLGNTACKVPDAISYIEKARNRTK
>NZ_MDFD01000004.1|WP_003722739.1|21703_22645_+|L-lactate-dehydrogenase
MKDHQKIILVGDGAVGSSYAFACVNLSIGQEFGIIDIDKDRTIGDAMDLSHAVPFSTPKKIYSANYSDCHDADLVVVTAGTAQKPGETRLDLVNRNIKIMKGIVDEVMASGFDGIFLIASNPVDILTYATWKFSGLPKERVIGSGTSLDTARFRMSIADYLKVDARNVHGYILGEHGDTEFPAWSHTTVGGLPITEWISEDEQGAMDTIFVSVRDAAYEIINKKGATFYGVAAALARITKAILNNENAILPLSVYLDGHYGMNDIYIGAPAVVNRQGVRHIVEMNLNDKEKEQMKNSADTLKKVLDDAMKQID
>NZ_MDFD01000004.1|WP_003722740.1|20786_21410_-|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MATTLEVQKRETTQHSEVTRLRSEGKVPGIIYGYKSENVPVSVDSLELIKAVRDNGRNAVFSVTVDGKKLNVLLHEYQVDPLKDVLVHVDLLAVDMNEEVETDVRVVLVGDAPGVKAGGVLQQIIHDVKVSATPEKLPETIELDISSLEIGDVLTTNDLPENKDYVVQAEEEETVVTVSAPRAEEEPTTTEAPEPEAVHGKDEEPVE
>NZ_MDFD01000004.1|WP_012952051.1|20112_20697_-|GNAT-family-N-acetyltransferase
MLDKSVPHISVIMVNHDATNYPEFHLPAGYFFCFYKDGLEEDWCRLQLETGQVLSMDSIRARFETEFGNEKEKLTKRCIFVKAPNGEIIGTAMLWDGNTFGKMESRIHWVAVLDSHGGKGIAKALLSKILGLNKSKFVYLTTQTGSYQAIYLYRKFGFEKYVGKTPENWKTVNFQEEKETAWQIIENKIAEHQA
>NZ_MDFD01000004.1|WP_003722742.1|19445_20006_-|aminoacyl-tRNA-hydrolase
MKLIAGLGNPGKKYERTRHNVGFMVVDELSFRHQTPWKKSKFNGMTSEIIVGGEKMILVKPLTFMNASGECIRPLMDYYNIPIEDVVIVYDDLDLPVGKIRLRQKGSAGGHNGMKSIIQHVKTQEFNRIRVGVSRPLKGEVINYVLGDFPKAEQPDIIAAIQKSADAIEDFAQTPFIEVMNKYNQK
>NZ_MDFD01000004.1|WP_010989376.1|15791_19331_-|transcription-repair-coupling-factor
MKGLQQLIYEQKDIRAVLNALDEKEKAQLVTGLTGSSRALFASVVEGASKRPVVFVTHNLYHAQKLYDDLLSLMDVDRLFLYPADELISSELSISSPELRGQRVEALDFLLSGKPGIVIVPVAGLRKMLPPVSLWKHFNISIVEGEEIDPDVLRQKLVTMGYTMSGMVNTPGEFSVRGGIIDIYPITEEFPIRIELFDTEVDSLRFFDVETQRSTTRVEEFRLLPATEIILDQSYYPDIVKRLEKKMMLTLNELKEQEDKQALIENLEEDLEMLRSGVKPDMFFKYIGLAYPDPASLFDYLPKNTAILLDEFGRILETEESLEREEAEWQTETLSRMETVRDVQVSHSFKKLLEGNHSPKIYLSLFQKQMASMRVSKTTNIVYKQMQQFHGQMNVLKTELESWHKNNYAVVILAPNLERAEKMQQTLTDYDMESTILKKESDVPKYGMVQFVIGTFQNGFELPLAKVAIISETELFNKKIKKVKKRQKLSNAERIQSYSELKVGDYVVHVNHGIARYVGMETLDINGVHKDYLLLVYQGEDKLFIPVDQLDLVQKYVGAEGKSPRLNKLGGAEWKRVKKKVQASVQDIADDLIKLYAEREAEKGYAFSADDEMQREFEEAFPYQETEDQLRSISEIKKDMERPRPMDRLLVGDVGYGKTEVALRAAFKAIMDGKQVAFLVPTTILAQQHFETMKERFQGFPIEIGLLSRFRTKKQQTETLKGMKNGTVDVVVGTHRLLSKDVEYQDLGLLIVDEEQRFGVTHKEKIKQMRSKIDVLTLTATPIPRTLHMSMLGVRDLSVIETPPANRFPVQTYVAEQNNVLVREAIERELARDGQVYYLYNRVESITQKADEISAMVPDARVATAHGQMGESELESVILSFLEGEFDVLVTTTIIETGVDIPNVNTLFVQDADRMGLSQLYQLRGRVGRWNRIAYAYFMYQKDKILREEAEKRLSAIKEFTELGSGFKIAMRDLSIRGAGNILGAQQHGFIDSVGFDLYSQMLKEAIEAKKPKEEQKQIVPVEIDIQADAYIPEYYITDGRQKIEMYKRFRNIETLSELEDLQSDMIDRFGEYPEEVEYLFTMTELKVRALEVGIESVKQEQNKITMLFSESGTAGIRGDIVMQIIGEFGRMVGVGMEGTQLKITINVQNKPLKEWLYQVKSLAEKLRGAMKEKASTEN
>NZ_MDFD01000004.1|WP_012952055.1|27859_29392_-|zinc-metalloproteinase-Mpl
MKSKLICIIMVIAFQAHFTMTVKADSVGEEKLQNNTQAKKTPADLKALPDSCEAKDFYKNFKILDMTKDKLGVTHYTLALSSGGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYVGNPVKEKEIILNSRTKRLVYNIKLIFAEPEVASWIVQVDVETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRTHKGLIRTFDLKHNTDTSFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYEYYKNVHQLESLDGKGGEIDSFVHYGLNCNNAFWDGQEILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGSRDGRIRSIKDPDKYNQAAHMKDYESLPITEEGDWGGVHYNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKSQFTDAKKALQQAAKDLYGEDASKKVAEAWEAVGVN
>NZ_MDFD01000004.1|WP_003722731.1|29722_31312_-|cholesterol-dependent-cytolysin-listeriolysin-O
MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE
>NZ_MDFD01000004.1|WP_012952056.1|31553_32507_+|phosphatidylinositol-specific-phospholipase-C
MYKIYLRRTLVLVLCFILCFFTFPLGGKAYSLNNWNKPIKNSVTTKQWMSALPDTTNLAALSIPGTHDTMSYNGDITWTLTKPLAQTQTMSLYQQLEAGIRYIDIRAKDNLNIYHGPIFLNASLSGVLETITQFLKKNPKETIIMRLKDEQNSNDSFDYRIQPLINIYKDYFYTTPRTDTSNKIPTLKDVRGKILLLSENHTKKPLVINSRKFGMQFGAPNQVIQDDYNGPSVKTKFKEIVQTAYQASKADNKLFLNHISATSLTFTPRQYAAALNNKVEQFVLNLTSEKVRGLGILIMDFPEKQTIKNIIKNNKFN
>NZ_MDFD01000004.1|WP_003722729.1|32777_33491_+|listeriolysin-O-transcriptional-regulator-PrfA
MNAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGIAHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN
>NZ_MDFD01000004.1|WP_003722728.1|33533_34490_-|ribose-phosphate-diphosphokinase
MSNEYFDPKLKIFSLNSNRELAEEIAKEVGIELGKSSVTHFSDGEIQINIEESIRGCHVYVIQSTSNPVNQNLMELLIMIDALKRASAATINIVMPYYGYARQDRKARSREPITAKLVANLIETAGATRMITLDMHAPQIQGFFDIPIDHLNAVRLLSDYFSERHLGDDLVVVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVAEVMNIVGNVEGKVCIIIDDIIDTAGTITLAAKALREAGATKVYACCSHPVLSGPAMKRIEESPIEKLVVTNSIALPEEKWIDKMEQLSVAALLGEAIVRVHENASVSSLFE
>NZ_MDFD01000004.1|WP_003722727.1|34540_35914_-|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MSKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLNVDKVVTIVGHGAEKVQEHLAGKSEFVKQDEQLGTAHAVLQAKAELAGKDGVTLVVCGDTPLIEASTMEALLKYHHEKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDATEKEQRISEINTGTYCFDNKALFEALENVSNDNVQGEYYLPDVIKILKDSDEVVAAYRMESFEESLGVNDRIALAEASKLMQRRINENHMRNGVTLVNPESTYIDIDVKIGQDTVIEPGVMLRGKTVIGDDCVVTSGSEIVNSVIGERVHVRTSSIFESKVGDDVQIGPYAHLRPESDIHDHVKIGNYVETKKAVVGEGTKLPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDNVFVGCNSNLIAPVKVGDRAFIAAGSTITKDVPEDALGIARAKQDNKLGYAKHLNHGK
>NZ_MDFD01000004.1|WP_003722726.1|36300_36609_-|septation-regulator-SpoVG
MQVTDVRLRRVETDGRMRAIASITLDEEFVVHDIRVIDGNNGLFVAMPSKRGVDGEFRDIAHPINSDTRAKIQEVVLAEYERVGEEEATAVTEEESESVSAE
>NZ_MDFD01000004.1|WP_003722725.1|36728_37037_-|septation-regulator-SpoVG
MEITDVRLRRVETDGRMKAISSITIDGEFVIHDIRVIDGNEGLFVAMPSKRTPDGEFRDIAHPINSGTRAKIQEAVLAAYEVADEPAVNEESSADESIVEEN
>NZ_MDFD01000004.1|WP_009931069.1|37721_38930_-|ABC-transporter-permease
MNVLQSMKMAWKQLKASKLRSFLTMLGIIIGVASVILLVSLGNGVTQEVDDQMGDLGSNLITVVNSSVNPNDKYTYDEVMKYQNIDGVKSVSPELSGQVNATFDYKNSSNKVIGTNDQYKAARSLEMKEGRFLLPIDTEYGQKVAVIGSTVASDLFGFGDPIGETIRLNGMPYKVVGVLKEKGASMMGSSDDQIFIPISSAQRLLKDTNVRTIYVETKSAEDVDFVVNTLESRLAIKFGDEKEQEKNASSAQMGPSYQVINQQEILNAFNTISTTLTTALGAIAAISLVVGGIGIMNIMLVSVSERTREIGIRKALGAKKRAILLQFLIESIVISVCGGVIGIIIGVSGALIFGSVAGISSGITAGTIIFSFVFSLCIGVIFGIAPANKASKLRPIDALRSE
>NZ_MDFD01000004.1|WP_003722723.1|38926_39619_-|ABC-transporter-ATP-binding-protein
MPKPLIDMKNLTKTYTLGGETFKALDDVTFTVEQGEFLSIVGPSGSGKSTLMNMIGCLDVPDEGSYHLDDVDVFKLSDNKLSEIRNKKIGFIFQQFNLLPKLSAFENVELPLIYAGLSVSAREKAAIECLEKVGLLEKRRNLPTQLSGGQQQRVAIARALAGKPQILLADEPTGALDSKTGKEVMGILQELNRAGNTIVMITHDPTIASYGTRSIRIQDGKLFHEEATQA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage