CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_MDMC01000001	Listeria monocytogenes strain Lm105 contig000001, whole genome shotgun sequence	0 crisprs	NA	0	1	0
NZ_MDMC01000003	Listeria monocytogenes strain Lm105 contig000003, whole genome shotgun sequence	1 crisprs	cas3	0	0	0
NZ_MDMC01000011	Listeria monocytogenes strain Lm105 contig000011, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_MDMC01000004	Listeria monocytogenes strain Lm105 contig000004, whole genome shotgun sequence	0 crisprs	NA	0	1	0
NZ_MDMC01000002	Listeria monocytogenes strain Lm105 contig000002, whole genome shotgun sequence	0 crisprs	NA	0	1	0
NZ_MDMC01000007	Listeria monocytogenes strain Lm105 contig000007, whole genome shotgun sequence	0 crisprs	DinG	0	1	0
NZ_MDMC01000006	Listeria monocytogenes strain Lm105 contig000006, whole genome shotgun sequence	1 crisprs	csa3,DinG	0	1	0
NZ_MDMC01000014	Listeria monocytogenes strain Lm105 contig000014, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_MDMC01000010	Listeria monocytogenes strain Lm105 contig000010, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_MDMC01000005	Listeria monocytogenes strain Lm105 contig000005, whole genome shotgun sequence	0 crisprs	csa3,WYL	0	1	1
NZ_MDMC01000013	Listeria monocytogenes strain Lm105 contig000013, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_MDMC01000012	Listeria monocytogenes strain Lm105 contig000012, whole genome shotgun sequence	0 crisprs	NA	0	0	0
NZ_MDMC01000008	Listeria monocytogenes strain Lm105 contig000008, whole genome shotgun sequence	2 crisprs	casR,WYL	1	0	0
NZ_MDMC01000009	Listeria monocytogenes strain Lm105 contig000009, whole genome shotgun sequence	0 crisprs	cas3,DEDDh	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_MDMC01000006_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_MDMC01000006_1

114045-114155

Orphan

Consensus_repeat	Method
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_MDMC01000006_1

>merge|NZ_MDMC01000006|1|114045-114155|CRISPRCasFinder
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAATGTACTTTATTTTGATTTAGTTCTTCAATATAAATCTGAGCAAAGCGATGATTTAATCCTTCCCAGAACTTTCAAAA

>NZ_MDMC01000006|1|1|114045-114155|CRISPRCasFinder
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA	TGTACTTTATTTTGATTTAGTTCTTCAATATAAATCTGAGCAA
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA

Protein	Signature genes	Signature genes Name	Protein_function
NZ_MDMC01000006.1\|WP_009931588.1\|117086_117242_+\|hypothetical-protein	unknown	unknown	unknown
NZ_MDMC01000006.1\|WP_009930437.1\|105970_106960_+\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|237724
NZ_MDMC01000006.1\|WP_003732084.1\|112191_113931_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
NZ_MDMC01000006.1\|WP_003722056.1\|106981_107578_+\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
NZ_MDMC01000006.1\|WP_003722061.1\|110879_111125_-\|YaaL-family-protein	unknown	unknown	gnl\|CDD\|378478
NZ_MDMC01000006.1\|WP_003727657.1\|114739_114922_-\|DUF3188-domain-containing-protein	unknown	unknown	gnl\|CDD\|371501
NZ_MDMC01000006.1\|WP_003732088.1\|120782_121721_-\|GW-domain-containing-glycosaminoglycan-binding-protein	unknown	unknown	gnl\|CDD\|226309
NZ_MDMC01000006.1\|WP_010990045.1\|109031_109871_+\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|319818
NZ_MDMC01000006.1\|WP_010990044.1\|108061_108913_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
NZ_MDMC01000006.1\|WP_003725004.1\|115280_116645_-\|PTS-sugar-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
NZ_MDMC01000006.1\|WP_003722074.1\|121763_122711_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NZ_MDMC01000006.1\|WP_003722063.1\|111844_112162_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
NZ_MDMC01000006.1\|WP_003722065.1\|114257_114722_-\|DUF3284-domain-containing-protein	unknown	unknown	gnl\|CDD\|378692
NZ_MDMC01000006.1\|WP_003732087.1\|119152_120667_-\|gluconokinase	unknown	unknown	gnl\|CDD\|212659
NZ_MDMC01000006.1\|WP_003722067.1\|114924_115146_-\|hypothetical-protein	unknown	unknown	unknown
NZ_MDMC01000006.1\|WP_014601547.1\|122851_124591_-\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|227320
NZ_MDMC01000006.1\|WP_009930438.1\|107581_107956_+\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	unknown	unknown	gnl\|CDD\|184702
NZ_MDMC01000006.1\|WP_009931159.1\|109991_110834_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223729
NZ_MDMC01000006.1\|WP_009925039.1\|117813_118455_-\|hypothetical-protein	unknown	unknown	unknown
NZ_MDMC01000006.1\|WP_003722062.1\|111139_111736_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616

Protein	Function_ID	Function_description	E-value
NZ_MDMC01000006.1\|WP_003722074.1\|121763_122711_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	1.13667e-05
NZ_MDMC01000006.1\|WP_009930437.1\|105970_106960_+\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
NZ_MDMC01000006.1\|WP_003732084.1\|112191_113931_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
NZ_MDMC01000006.1\|WP_003722056.1\|106981_107578_+\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	3.29756e-82
NZ_MDMC01000006.1\|WP_003722061.1\|110879_111125_-\|YaaL-family-protein	gnl\|CDD\|378478	pfam10704, DUF2508, Protein of unknown function (DUF2508). This family is conserved in Firmicutes. Several members are annotated as being the protein YaaL. The function is not known.	2.68189e-15
NZ_MDMC01000006.1\|WP_003727657.1\|114739_114922_-\|DUF3188-domain-containing-protein	gnl\|CDD\|371501	pfam11384, DUF3188, Protein of unknown function (DUF3188). This bacterial family of proteins has no known function.	1.21027e-11
NZ_MDMC01000006.1\|WP_003732088.1\|120782_121721_-\|GW-domain-containing-glycosaminoglycan-binding-protein	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	3.04876e-98
NZ_MDMC01000006.1\|WP_010990045.1\|109031_109871_+\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.49073e-86
NZ_MDMC01000006.1\|WP_010990044.1\|108061_108913_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	6.1079e-63
NZ_MDMC01000006.1\|WP_003725004.1\|115280_116645_-\|PTS-sugar-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	3.47828e-162
NZ_MDMC01000006.1\|WP_003722063.1\|111844_112162_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	3.53269e-41
NZ_MDMC01000006.1\|WP_003722065.1\|114257_114722_-\|DUF3284-domain-containing-protein	gnl\|CDD\|378692	pfam11687, DUF3284, Domain of unknown function (DUF3284). This family of proteins with unknown function appears to be restricted to Firmicutes.	5.35099e-31
NZ_MDMC01000006.1\|WP_003732087.1\|119152_120667_-\|gluconokinase	gnl\|CDD\|212659	cd07770, FGGY_GntK, Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of a group of gluconate kinases (GntK, also known as gluconokinase; EC 2.7.1.12) encoded by the gntK gene, which catalyzes the ATP-dependent phosphorylation of D-gluconate and produce 6-phospho-D-gluconate and ADP. The presence of Mg2+ might be required for catalytic activity. The prototypical member of this subfamily is GntK from Lactobacillus acidophilus. Unlike Escherichia coli GntK, which belongs to the superfamily of P-loop containing nucleoside triphosphate hydrolases, members in this subfamily are homologous to glycerol kinase, xylulose kinase, and rhamnulokinase from Escherichia coli. They have been classified as members of the FGGY family of carbohydrate kinases, which contain two large domains separated by a deep cleft that forms the active site. This model spans both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Some uncharacterized homologous sequences are also included in this subfamily. The Lactobacillus gnt operon contains a single gntK gene. The gnt operons of some bacteria, such as Corynebacterium glutamicum, have two gntK genes. For example, the C. glutamicum gnt operon has both a gluconate kinase gntV gene (also known as gntK) and a second hypothetical gntK gene (also known as gntK2). Both gluconate kinases encoded by these genes belong to this family, however the protein encoded by C. glutamicum gntV is not included in this model as it is truncated in the C-terminal domain.	0
NZ_MDMC01000006.1\|WP_014601547.1\|122851_124591_-\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|227320	COG4987, CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
NZ_MDMC01000006.1\|WP_009930438.1\|107581_107956_+\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	gnl\|CDD\|184702	PRK14484, PRK14484, phosphotransferase mannnose-specific family component IIA; Provisional.	1.1917e-48
NZ_MDMC01000006.1\|WP_009931159.1\|109991_110834_+\|aldo/keto-reductase	gnl\|CDD\|223729	COG0656, ARA1, Aldo/keto reductases, related to diketogulonate reductase [General function prediction only].	6.97706e-130
NZ_MDMC01000006.1\|WP_003722062.1\|111139_111736_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	7.77001e-132

>NZ_MDMC01000006.1|WP_003732084.1|112191_113931_-|DNA-polymerase-III-subunit-gamma/tau
MAYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAKAINCEHGHDGEPCNECEICKGTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKYKVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPHKLPLTIISRVQRFDFKRITTQDIIGRLKFILEEEKIPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVEDALEITGSVAQNLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPNLEETMERALIDDDFVALAKRADSLKVYEFVKILNTAQQQMRFSNHPGIYVEVALVQLTQAGQSVAGGGNVPADAASGSDVSDLKRQMEQMHQEIQTLKKQIASGAGAAPADKPTQNRGGSKKAINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAASQDTFVLKFKHEIHCQMAMDNPNFVETITSSIARLTQVNYTFIGIPEDQWADVRENFLHSHGSDADAEDGANPEAKKPAEDPFVAEAAKLVGEDLLEIKD
>NZ_MDMC01000006.1|WP_003722063.1|111844_112162_-|YbaB/EbfC-family-nucleoid-associated-protein
MRGMGNMQGMMKQMQKMQKEMAKAQADLEAQEFTGTAGGGMVTVKATGKRVITDVVINEEVVDPEDIEMLQDLVLAATNDVLKQIEDTTSQTMGKFTQGLNIPGM
>NZ_MDMC01000006.1|WP_003722062.1|111139_111736_-|recombination-protein-RecR
MHYPEPITKLIDSFMKLPGIGPKSAARLAFYVLDMKEDDVLDFAKALVDAKRNLSFCSVCGHITDKDPCYICADTSRDRSVICVVQESKDVIAMEKMRDFHGLYHVLHGTISPMDGIGPEDINIPDLLKRLQDDTIEEVILATNPNVEGEATAMYISRLLKPSGIKVTRIAHGLPVGGDLEYADEVTLSKAMEGRREV
>NZ_MDMC01000006.1|WP_003722061.1|110879_111125_-|YaaL-family-protein
MESRSNKFGRKKNKKIGKLHKSYDAYLMELIEVTQENWHKQKVLMRKSFEYDPNLEYEEKKAEARYFYLFKEARTRQLKNK
>NZ_MDMC01000006.1|WP_009931159.1|109991_110834_+|aldo/keto-reductase
MTLSFSDTYRLNNGIEMPRHGFGVYKLTDEARMRTALETAVDVGYRLFDTASFYHNEKELGDFFASSGLKRDEFFVTTKMWNTEQGYDETLRAFEKSQKKLQLDQIDLYLVHWPKQDTFFDTWRAVEKLYDEGLVRAIGVSNFEAHHLDRLRTSANVLPVVDQLETHPHFPNHLLHRYLEELHIVHQAWSPLGRGGVLQEQILIDLAEKHGKSPAQIVLRWHLQNNISIIPKSETPSRIRENAAIYDFELSEADMRQVERLNTGERVSHAPDVMYVRSEI
>NZ_MDMC01000006.1|WP_010990045.1|109031_109871_+|Cof-type-HAD-IIB-family-hydrolase
MTTQAIILDIDGTLLNDDKQISPETKKALITAQENGVKLILASGRPTTGMHVYAEQLEMEKHHGLLVSYNGAKVVDCATNEELFNQALTVEEGKAVLEHMKQFEVKVMIDKEDYMYTNDVYDCYVPYRGEEINIIQYESRGGNFKLCEKDDLAAFLDYRLSKILTAGDPAYMQKNYQAMMAPFKDTLNCVFTADFYFEFTAQGIDKAKALDTVLTPMGIHAENVIAFGDGHNDITMVEYAGTGIAMQNAVPELKAAASSVTLSNNEDGIAHVLNSLIPS
>NZ_MDMC01000006.1|WP_010990044.1|108061_108913_+|MurR/RpiR-family-transcriptional-regulator
MNILIKIRELTNLTNSEKELANYILANPKKTLQFKPKELATAAFVSAATIYRLINKLGLNGIGELKIEIASSLRETSEEKDLNYDYPILESDTPYQIMTNLHQIYKGTIDETLNNADPEELVKIGEKLIQAKTIDVYAASANLFFAQNFKFQMQEIGVLVNVPEEDYIQSLSAANSDENHIAIVVSYGGRSRTLQRVVKILSENNVDIILITSMQDNPLVEFATHKIYMASAENHYNKVSSFSTRQSLLSIFDTLYSIYFNQNYEKNIQYKTTNYQKMNTELE
>NZ_MDMC01000006.1|WP_009930438.1|107581_107956_+|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM
MAKPYGVVIISHSKDVAKGVHDIIKEIAPDVSITHAGGTEDGRIGTSFDAVNEAIENNEANKVYTFYDLGSAKMNIETVEEISEKEIILFNAPILEGAYATAAQVQMDEKPEVIAANLKTIEIK
>NZ_MDMC01000006.1|WP_003722056.1|106981_107578_+|dihydroxyacetone-kinase-subunit-L
MTYDKDWALRWLNDFGERVQENKQLLSDLDQAIGDGDHGINMARGLGELKKAFTEKEPADLKDVFKTAGMTMVSKVGGASGPLYGTAFLNMSKAVDADTIDAVGLTKVIEAGLEGIEKRGKSHAGEKTMIDVWEPVVHALHQEDLTDDVVDAALQKTKDLKATKGRASYLGERSIGHLDPGAYSSALLFHAMLQTEVS
>NZ_MDMC01000006.1|WP_009930437.1|105970_106960_+|dihydroxyacetone-kinase-subunit-DhaK
MKKILNGTDQVVEQMVEGLVKSHADVVHRVEGTRVIARNDKRPGKVGLVSGGGSGHEPAHAGYVGRGMLSAAVCGDVFTSPTPDQIYEGIKAADQGAGVLLIVKNYTGDVMNFEMAADLADADDIKVEQIVVDDDIAVEDSTFTTGRRGVAGTVLVHKIIGAAAEAGASLDELKALGEKVIASVKTLGVALSPCTVPEVGHPGFELGDDEIELGIGIHGEPGFTREKIMPSASLAKQLYERISNESKLLAGDKVVVLVNGMGATPLMEQYVFANDVHELLKNAGVQVEKTLVGDYMTSLEMAGLSLTILKLEDEKWVDMLKLPVDTIAW
>NZ_MDMC01000006.1|WP_003722065.1|114257_114722_-|DUF3284-domain-containing-protein
MNVTQKLYISQKECFDTLVSSAIYDVKNATGKTLQVRKLEGYKYQRTMSNGALATTKIVKVQPNELYQFETSSRVNTHTTTYTIKSTSETTCEVTYNELIETEKALNKMNNIIVGFMFGFFRKKRVKNLLKSIELSVINESKQKQEKLAAKSEQ
>NZ_MDMC01000006.1|WP_003727657.1|114739_114922_-|DUF3188-domain-containing-protein
MKIVNALFLISIGLIIIMFSPSYGKDGMASVPLLVTGLAVVLIGCVFIVLKIRKDKKEKN
>NZ_MDMC01000006.1|WP_003722067.1|114924_115146_-|hypothetical-protein
MIILNCPMKRDYITELLETYDKDGVTFKKIDEKGMKLTFETNIEDEEKAAKIAKETIKATEIGSVLYFQVSVG
>NZ_MDMC01000006.1|WP_003725004.1|115280_116645_-|PTS-sugar-transporter-subunit-IIC
MNGLTAFLEKYFVPVAAKIGSQKHLVALRDAFISTMPITMAGSIAVLLNAFFRDFPTDWGWTGFVEAMQPLIGINGYVYNGTLAIVSIIFAFSLGYNLSKAYEVDRLAGGLVSLAAFVMNLTVTVSLDAVKAAIAASNANFDVATLPKEFAGIYGFFSLSQVNGTGLFTAMIFGFISTIIYAKLMRRNIIIKMPDSVPPAVSKAFAAIIPALVALYVVGIIDWAFFKITNMDVITWISKTIQEPLLSLSQGYGAVLLVTFLVQLLWFFGIHGPNVLAPVLESLWGTAQLQNISAAQEGAKLPFEWVRGSFDAYVWMGGSGGTLVLIIALLMFSKRADARTVAKLSLAPGIFNINEPIMFGLPIVLNTIYLIPFLIAPMVMVTIAYFATTLGIVGPVKIAVVWVMPPLLNSFLATGGDWMAPVISLINMVVAFLIWVPFVITANRVGVPEEEMKA
>NZ_MDMC01000006.1|WP_009931588.1|117086_117242_+|hypothetical-protein
MAVKRDMPEESKNSKVVKKEHFSIVFPDDIKEPATVEEKKKQDAEKKTDDN
>NZ_MDMC01000006.1|WP_009925039.1|117813_118455_-|hypothetical-protein
MQQLKSKKKWLPALIVAVFVGIIVILAIMFGFFQRQEVFDKYEVAYEIDGKLYEVFPISATDIGVDKKSKDKNLYFRVNSYYNIDYLFRLAYKQYEINEPSTNKYYSGLIDYSVADNAYVTQKDVYITNNESYATYDFFDKNGKKIYTYNPEETSNDDYIVRIKPTILQGYEKSDIGSYDDYLNITALFKDKLGMDVNVRIDEDKEMVIFSIK
>NZ_MDMC01000006.1|WP_003732087.1|119152_120667_-|gluconokinase
MTSKPYIMGVDIGTSSTKAVLFNQRGEVIFRQATHYELITDETGKAEESPTEIFDAVLTSIQAVMKNINTEELAGISFSSAMHSLIMVGSNGELLTECITWADGRSSETLEKVKRDNYLFQLYEATGTPIHPMSPFAKICWLKEEKPTLFKRTEKFVDIKSYILYRLFGVWVMDESLASGTGLYNIMEHDWEFEAMEIVKLTPDFLPKVVPETYQLAGVKKEYAELMGIPENLPFIIGGSDGALANIGIQATGQNDVTITVGTSGAVRKLTDQFQIDSRGRTFCYGAGDGYFIAGGAVNNGGKVVEWGLQQFGSEAEISRRDFASFIAKIEEVPPGAAGLLFQPYLLGERAPFWTNDIRGGFVGLTINHTKAHFIRAILEGVAFNLAEVYEAVSAPDDIIYVTGGISAHDAWCKLLADILNREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKHTLPIKAVYHPSENVLKYAELRLIFKQVTTQLMSSYSQLNSWQKKFDINS
>NZ_MDMC01000006.1|WP_003732088.1|120782_121721_-|GW-domain-containing-glycosaminoglycan-binding-protein
MKKLLSGLIVVLMVSLLGHSFNAEAASYEKIIYDKAVNLKGVVNQSKRNDGINSKMYKTSSSVKYLGSAKKYDKKTLIITREGKTARAKWYYCKLGNTTIGWIDSRAFTNIGKPTIADAVPALWNSKKAIITTKPKSTTATTYFFQKNSAGNWYEVRHFTSHIGKWGFDPKFSEKSSGTPVGVYRTGIAFGQKGNPGTKLTFRAITNRSYWISNSNDKAYNTWQERNSSSSADEKMKIPQYKYGMEVKYNAKRVKGKGSAVFYHVDSPKYNYTLGCVAQSEANTKEVLKFADKNTLIVLGEESRIKTFYGIN
>NZ_MDMC01000006.1|WP_003722074.1|121763_122711_-|LPXTG-cell-wall-anchor-domain-containing-protein
MKKFHGLILTALVTCLIIPFSLAASAETNENGNNSTPTEEKTTDTTENIITEEKTEPAEPTKDTTVTPPQKSKVQTTIDITDSQEVYSYEQNSKIDLKDFTATLTDYTDTKLTNYRLAANSKLSTAQTGIQEVTLLGDNEDGKTTAVKLNYLVKEKTAQLTITDMNFDLETKIFTGKTKPFASVYMSSPADENFGEGTTTADKDGYFYAEWATTPKQITAYAFDESGNYSEEVTYQVPAKKQNEAVVTAPDKVKKIETKNAVKSATTKPTDVTKVTKDDKTDLPSTGDKGTEWIFVVAGVIVILVAVLLLRKRKK
>NZ_MDMC01000006.1|WP_014601547.1|122851_124591_-|thiol-reductant-ABC-exporter-subunit-CydC
MRKSSWIIPYIKENRGLFLLVIFLGTLTFASAGALMFTSGHLISKSSLMPESIMAVYISTVGVRAFGIMRSVSRYVERLSSHSLVLRILEKMRVRLYRLLEPQALLLKSRYKTGDILGLLAGDIEHLQNFYLTTMLPAIVSLVLYAGVVIALGAFSIPFAALFVLLIGLLVLVLPWVSLLYARGKNAYLKQGRNSLYQKFTDAVFGISDWKFSGREKTFISNYEKDEADMLRTENKQFHFVNWRDFFSQLVVGFMVIVMVYWSTAESRDGAFSGTLIAAFVLAIMALAEAFVPVSSAISDKSLYQDSLARLDKIEDPALPTFEEETKEIERINTENVVLKAENLTFAYNEKSPEILNGFDFTLQQGEKVAIIGRSGTGKSTFLKLVQGALLPTAGKVTMNDVEVEKLRPQIPELTSMLNQKAHLFSTTVLNNIRLGNQDASDEEVYEAAKKVQLHDFIMSMPDGYHTQMSEMGERFSGGERGRIALARILLQNTPIVILDEPTVGLDPITERDLLATIFETLADKSLIWVTHHLVGAEKMDRVLFLEEGKTLMEGPHAELMAEEPRYKRLYQLDRPIEL

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

399105 : 409832

Listeria_phage(40.0%)

holin,tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003721739.1\|399105_399558_-	ImmA/IrrE family metallo-endopeptidase	A0A059T7S0	Listeria_phage	4.0e-31	47.9
WP_003721740.1\|399563_399899_-	helix-turn-helix transcriptional regulator	A0A2H4JAR9	uncultured_Caudovirales_phage	4.0e-20	52.5
WP_003732219.1\|400115_400544_+	hypothetical protein	A8ATZ8	Listeria_phage	3.0e-12	45.7
WP_003721742.1\|400555_400972_+	hypothetical protein	NA	NA	NA	NA
WP_009930418.1\|401249_401639_+	DUF5072 family protein	NA	NA	NA	NA
WP_003721744.1\|401651_402164_+\|tail	phage major tail protein, TP901-1 family	A0A097PBF4	Streptococcus_pyogenes_phage	1.2e-47	62.7
WP_003721745.1\|402211_402514_+	hypothetical protein	NA	NA	NA	NA
WP_009930419.1\|402555_402960_+	hypothetical protein	A0A097PAX1	Streptococcus_pyogenes_phage	1.8e-19	43.5
WP_010989347.1\|402946_404815_+	membrane protein	A0A097PAU2	Streptococcus_pyogenes_phage	3.5e-20	45.8
WP_009911828.1\|404811_405630_+\|tail	phage tail family protein	Q9T1A6	Listeria_phage	7.4e-44	35.5
WP_010989348.1\|405639_406776_+\|tail	phage tail protein	A0A0B5D0G3	Listeria_phage	1.0e-46	33.8
WP_003721751.1\|406765_407065_+	hypothetical protein	NA	NA	NA	NA
WP_009931689.1\|407079_407655_+	hypothetical protein	NA	NA	NA	NA
WP_009931691.1\|407669_408149_+	hypothetical protein	NA	NA	NA	NA
WP_003732226.1\|408145_408682_+	hypothetical protein	NA	NA	NA	NA
WP_003721755.1\|408700_409123_+\|holin	holin family protein	Q2I8E7	Bacillus_phage	1.1e-27	46.3
WP_010989349.1\|409103_409832_+	N-acetylmuramoyl-L-alanine amidase	A0A0N9SGH1	Paenibacillus_phage	5.6e-35	42.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NZ_MDMC01000001

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

34656 : 47780

Listeria_phage(91.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003739618.1\|34656_35004_+	helix-turn-helix transcriptional regulator	A0A0U4JD08	Gordonia_phage	2.0e-06	42.6
WP_039388697.1\|35058_35535_-	competence protein ComK	NA	NA	NA	NA
WP_049891860.1\|35525_36884_-	recombinase family protein	Q8LTD8	Listeria_phage	2.5e-238	90.3
WP_003749252.1\|36950_37373_-	hypothetical protein	NA	NA	NA	NA
WP_003733641.1\|37385_37991_-	hypothetical protein	NA	NA	NA	NA
WP_069002781.1\|38013_38736_-	hypothetical protein	A0A059T7P9	Listeria_phage	6.9e-94	89.6
WP_003727739.1\|38751_38970_-	zinc-ribbon domain-containing protein	A0A059T6E3	Listeria_phage	5.4e-34	100.0
WP_003770011.1\|38992_39484_-	hypothetical protein	A8ATX4	Listeria_phage	3.9e-88	95.7
WP_031645987.1\|39516_39819_-	helix-turn-helix transcriptional regulator	A0A059T669	Listeria_phage	2.1e-20	52.0
WP_031645988.1\|39975_40206_+	helix-turn-helix transcriptional regulator	A8ATK0	Listeria_phage	2.4e-08	51.7
WP_014930211.1\|40209_40431_+	hypothetical protein	NA	NA	NA	NA
WP_069002783.1\|40427_40685_-	hypothetical protein	NA	NA	NA	NA
WP_003769999.1\|40749_40926_+	hypothetical protein	Q9T184	Listeria_phage	1.3e-09	100.0
WP_003769998.1\|40942_41098_+	hypothetical protein	Q9T183	Listeria_phage	2.2e-18	100.0
WP_015967158.1\|41099_41267_-	hypothetical protein	Q9T182	Listeria_phage	5.6e-23	100.0
WP_003735007.1\|41333_41528_+	hypothetical protein	A0A059T6E5	Listeria_phage	1.3e-26	100.0
WP_031660002.1\|41539_41776_+	hypothetical protein	A0A059T5E9	Listeria_phage	1.8e-35	94.9
WP_003725093.1\|41772_41940_+	hypothetical protein	NA	NA	NA	NA
WP_003725092.1\|41940_42144_-	KTSC domain-containing protein	A0A1S5S8T9	Streptococcus_phage	2.0e-14	56.7
WP_003747301.1\|42207_42981_+	phage repressor protein/antirepressor Ant	A8ATY0	Listeria_phage	2.4e-140	99.6
WP_009930464.1\|43101_43635_+	hypothetical protein	A0A059T5F0	Listeria_phage	1.1e-75	84.4
WP_003769990.1\|43631_43847_+	hypothetical protein	Q9T176	Listeria_phage	6.1e-22	73.2
WP_003769989.1\|43954_44143_+	hypothetical protein	A8ATY3	Listeria_phage	2.5e-27	95.2
WP_009930470.1\|44444_44639_+	hypothetical protein	A0A059T6E8	Listeria_phage	1.8e-28	95.3
WP_009930471.1\|44635_45112_+	siphovirus Gp157 family protein	A8ASN2	Listeria_phage	2.0e-57	94.9
WP_009930473.1\|45116_45755_+	ERF family protein	A8ASN3	Listeria_phage	3.0e-77	74.3
WP_031660000.1\|45768_46692_+	DnaD domain-containing protein	A0A0B5D175	Listeria_phage	1.9e-120	79.8
WP_014601515.1\|46688_47144_+	class I SAM-dependent methyltransferase	A0A059T693	Listeria_phage	4.2e-81	90.7
WP_014601514.1\|47148_47316_+	hypothetical protein	A8ASN5	Listeria_phage	2.4e-18	81.8
WP_069002785.1\|47327_47543_+	hypothetical protein	NA	NA	NA	NA
WP_140902974.1\|47621_47780_+	pentapeptide repeat-containing protein	A8ATE4	Listeria_phage	3.7e-08	96.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. NZ_MDMC01000003

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: NZ_MDMC01000003_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_MDMC01000003_1

26870-27021

Unclear

Consensus_repeat	Method
GAGCTCGGTTCCGATGTAGCAGGAGCATTAAAACCAAGAAGCATTGG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of NZ_MDMC01000003_1

>merge|NZ_MDMC01000003|1|26870-27021|CRISPRCasFinder
GAGCTCGGTTCCGATGTAGCAGGAGCATTAAAACCAAGAAGCATTGGCGTCTCTGGCAAAGCAAGTCTTAACTCTTCATCCGTAGGTGGTGGTGGAAATTCGAATGAGCTCGGTTCTGATGTAGCAGGAGCATTAAAACCAAGAAGCATTGG

>NZ_MDMC01000003|1|1|26870-27021|CRISPRCasFinder
GAGCTCGGTTCCGATGTAGCAGGAGCATTAAAACCAAGAAGCATTGG	CGTCTCTGGCAAAGCAAGTCTTAACTCTTCATCCGTAGGTGGTGGTGGAAATTCGAAT
GAGCTCGGTTCTGATGTAGCAGGAGCATTAAAACCAAGAAGCATTGG

Protein	Signature genes	Signature genes Name	Protein_function
NZ_MDMC01000003.1\|WP_003722723.1\|39129_39822_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
NZ_MDMC01000003.1\|WP_010989373.1\|28062_29595_-\|zinc-metalloproteinase-Mpl	unknown	unknown	gnl\|CDD\|225768
NZ_MDMC01000003.1\|WP_010989376.1\|15994_19534_-\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
NZ_MDMC01000003.1\|WP_003722742.1\|19648_20209_-\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|235457
NZ_MDMC01000003.1\|WP_003722731.1\|29925_31515_-\|cholesterol-dependent-cytolysin-listeriolysin-O	unknown	unknown	gnl\|CDD\|366559
NZ_MDMC01000003.1\|WP_003722725.1\|36931_37240_-\|septation-regulator-SpoVG	unknown	unknown	gnl\|CDD\|237321
NZ_MDMC01000003.1\|WP_003733144.1\|31756_32710_+\|phosphatidylinositol-specific-phospholipase-C	unknown	unknown	gnl\|CDD\|176497
NZ_MDMC01000003.1\|WP_010989375.1\|25039_25909_-\|phosphatidylcholine-phospholipase-C	unknown	unknown	gnl\|CDD\|214813
NZ_MDMC01000003.1\|WP_009924872.1\|24644_24968_-\|DUF5502-family-protein	unknown	unknown	gnl\|CDD\|340321
NZ_MDMC01000003.1\|WP_003722739.1\|21906_22848_+\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|178836
NZ_MDMC01000003.1\|WP_003722740.1\|20989_21613_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	unknown	unknown	gnl\|CDD\|235534
NZ_MDMC01000003.1\|WP_009930501.1\|20315_20900_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
NZ_MDMC01000003.1\|WP_003722729.1\|32980_33694_+\|listeriolysin-O-transcriptional-regulator-PrfA	unknown	unknown	gnl\|CDD\|223736
NZ_MDMC01000003.1\|WP_009931069.1\|37924_39133_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|182528
NZ_MDMC01000003.1\|WP_009931068.1\|34743_36117_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	unknown	unknown	gnl\|CDD\|184643
NZ_MDMC01000003.1\|WP_003722728.1\|33736_34693_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_MDMC01000003.1\|WP_003725735.1\|23665_23998_+\|putative-heavy-metal-binding-protein	unknown	unknown	gnl\|CDD\|179228
NZ_MDMC01000003.1\|WP_003722726.1\|36503_36812_-\|septation-regulator-SpoVG	unknown	unknown	gnl\|CDD\|237321
NZ_MDMC01000003.1\|WP_003722736.1\|24048_24510_-\|YehR-family-lipoprotein	unknown	unknown	gnl\|CDD\|227145
NZ_MDMC01000003.1\|WP_009930499.1\|22924_23599_+\|DNA-alkylation-repair-protein	unknown	unknown	gnl\|CDD\|378033

Protein	Function_ID	Function_description	E-value
NZ_MDMC01000003.1\|WP_003722723.1\|39129_39822_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	7.27113e-121
NZ_MDMC01000003.1\|WP_010989373.1\|28062_29595_-\|zinc-metalloproteinase-Mpl	gnl\|CDD\|225768	COG3227, LasB, Zinc metalloprotease (elastase) [Amino acid transport and metabolism].	7.98048e-139
NZ_MDMC01000003.1\|WP_010989376.1\|15994_19534_-\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
NZ_MDMC01000003.1\|WP_003722742.1\|19648_20209_-\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|235457	PRK05426, PRK05426, peptidyl-tRNA hydrolase; Provisional.	4.98809e-109
NZ_MDMC01000003.1\|WP_003722731.1\|29925_31515_-\|cholesterol-dependent-cytolysin-listeriolysin-O	gnl\|CDD\|366559	pfam01289, Thiol_cytolysin, Thiol-activated cytolysin.	1.50399e-178
NZ_MDMC01000003.1\|WP_003722725.1\|36931_37240_-\|septation-regulator-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	2.92652e-53
NZ_MDMC01000003.1\|WP_003733144.1\|31756_32710_+\|phosphatidylinositol-specific-phospholipase-C	gnl\|CDD\|176497	cd00137, PI-PLCc, Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C. This subfamily corresponds to the catalytic domain present in prokaryotic and eukaryotic phosphoinositide-specific phospholipase C (PI-PLC), which is a ubiquitous enzyme catalyzing the cleavage of the sn3-phosphodiester bond in the membrane phosphoinositides (phosphatidylinositol, PI; Phosphatidylinositol-4-phosphate, PIP; phosphatidylinositol 4,5-bisphosphate, PIP2) to yield inositol phosphates (inositol monosphosphate, InsP; inositol diphosphate, InsP2; inositol trisphosphate, InsP3) and diacylglycerol (DAG). The higher eukaryotic PI-PLCs (EC 3.1.4.11) have a multidomain organization that consists of a PLC catalytic core domain, and various regulatory domains. They play a critical role in most signal transduction pathways, controlling numerous cellular events, such as cell growth, proliferation, excitation and secretion. These PI-PLCs strictly require Ca2+ for their catalytic activity. They display a clear preference towards the hydrolysis of the more highly phosphorylated PI-analogues, PIP2 and PIP, to generate two important second messengers, InsP3 and DAG. InsP3 triggers inflow of calcium from intracellular stores, while DAG, together with calcium, activates protein kinase C, which then phosphorylates other molecules, leading to altered cellular activity. In contrast, bacterial PI-PLCs contain a single catalytic domain. Although their precise physiological function remains unclear, bacterial PI-PLCs may function as virulence factors in some pathogenic bacteria. They participate in Ca2+-independent PI metabolism. They are characterized as phosphatidylinositol-specific phospholipase C (EC 4.6.1.13) that selectively hydrolyze PI, not PIP or PIP2. The TIM-barrel type catalytic domain in bacterial PI-PLCs is very similar to the one in eukaryotic PI-PLCs, in which the catalytic domain is assembled from two highly conserved X- and Y-regions split by a divergent linker sequence. The catalytic mechanism of both prokaryotic and eukaryotic PI-PLCs is based on general base and acid catalysis utilizing two well conserved histidines, and consists of two steps, a phosphotransfer and a phosphodiesterase reaction. This superfamily also includes a distinctly different type of eukaryotic PLC, glycosylphosphatidylinositol-specific phospholipase C (GPI-PLC), an integral membrane protein characterized in the protozoan parasite Trypanosoma brucei. T. brucei GPI-PLC hydrolyzes the GPI-anchor on the variant specific glycoprotein (VSG), releasing dimyristyl glycerol (DMG), which may facilitate the evasion of the protozoan to the host#s immune system. It does not require Ca2+ for its activity and is more closely related to bacterial PI-PLCs, but not mammalian PI-PLCs.	8.10719e-115
NZ_MDMC01000003.1\|WP_010989375.1\|25039_25909_-\|phosphatidylcholine-phospholipase-C	gnl\|CDD\|214813	smart00770, Zn_dep_PLPC, Zinc dependent phospholipase C (alpha toxin). This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.	4.70099e-87
NZ_MDMC01000003.1\|WP_009924872.1\|24644_24968_-\|DUF5502-family-protein	gnl\|CDD\|340321	pfam17606, DUF5502, Family of unknown function (DUF5502). This is a family of unknown function found in Listeria.	9.06348e-49
NZ_MDMC01000003.1\|WP_003722739.1\|21906_22848_+\|L-lactate-dehydrogenase	gnl\|CDD\|178836	PRK00066, ldh, L-lactate dehydrogenase; Reviewed.	0
NZ_MDMC01000003.1\|WP_003722740.1\|20989_21613_-\|50S-ribosomal-protein-L25/general-stress-protein-Ctc	gnl\|CDD\|235534	PRK05618, PRK05618, 50S ribosomal protein L25/general stress protein Ctc; Reviewed.	2.38585e-63
NZ_MDMC01000003.1\|WP_009930501.1\|20315_20900_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	7.52035e-10
NZ_MDMC01000003.1\|WP_003722729.1\|32980_33694_+\|listeriolysin-O-transcriptional-regulator-PrfA	gnl\|CDD\|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	9.59942e-12
NZ_MDMC01000003.1\|WP_009931069.1\|37924_39133_-\|ABC-transporter-permease	gnl\|CDD\|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	2.47504e-62
NZ_MDMC01000003.1\|WP_009931068.1\|34743_36117_-\|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU	gnl\|CDD\|184643	PRK14354, glmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU.	0
NZ_MDMC01000003.1\|WP_003722728.1\|33736_34693_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	0
NZ_MDMC01000003.1\|WP_003725735.1\|23665_23998_+\|putative-heavy-metal-binding-protein	gnl\|CDD\|179228	PRK01119, PRK01119, putative heavy metal-binding protein.	8.98192e-61
NZ_MDMC01000003.1\|WP_003722726.1\|36503_36812_-\|septation-regulator-SpoVG	gnl\|CDD\|237321	PRK13259, PRK13259, septation regulator SpoVG.	5.03804e-54
NZ_MDMC01000003.1\|WP_003722736.1\|24048_24510_-\|YehR-family-lipoprotein	gnl\|CDD\|227145	COG4808, COG4808, Uncharacterized protein conserved in bacteria [Function unknown].	5.22035e-59
NZ_MDMC01000003.1\|WP_009930499.1\|22924_23599_+\|DNA-alkylation-repair-protein	gnl\|CDD\|378033	pfam08713, DNA_alkylation, DNA alkylation repair enzyme. Proteins in this family are predicted to be DNA alkylation repair enzymes. The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.	1.81561e-21

>NZ_MDMC01000003.1|WP_010989375.1|25039_25909_-|phosphatidylcholine-phospholipase-C
MKFKKVVLGMCLIASVLVFPVTIKANACCDEYLQTPAAPHDIDSKLPHKLSWSADNPTNTDVNTHYWLFKQAEKILAKDVNHMRANLMNELKKFDKQIAQGIYDADHKNPYYDTSTFLSHFYNPDRDNTYLPGFANAKITGAKYFNQSVTDYREGKFDTAFYKLGLAIHYYTDISQPMHANNFTAISYPPGYHCAYENYVDTIKHNYQATEDMVAKRFCSDDVKDWLYENAKRAKADYPKIVNAKTKKSYLVGNSEWKKDTVEPTGARLRDSQQTLAGFLEFWSKKTNE
>NZ_MDMC01000003.1|WP_009924872.1|24644_24968_-|DUF5502-family-protein
MYIKGRLIFFFVVLVIALCSVLILLIIKISVWKDEPFHLSDAKEIECLGSCEIKNTNQKIHFFSIKENLFEEKGDIAGILNEDEQKVADKSIFIVILDDEKGIANEE
>NZ_MDMC01000003.1|WP_003722736.1|24048_24510_-|YehR-family-lipoprotein
MKMLKKGTAVLFVMIMAVMLVACGDKEETKTYTLSQNGVDSKLTYTYKGDKVTKQTAENTMSYASLGVASKEDAEKMLKATSDKFQGIDGLKEKIEYKDDKAIETLEVDYTKISSEDMNKIPGMSSNGDTSKGISMEESAKMLESQGYKEVSK
>NZ_MDMC01000003.1|WP_003725735.1|23665_23998_+|putative-heavy-metal-binding-protein
MIVTTSPNIEGKQIIEYKKIVFGEVITGVNFMKDIGAGLRNFFGGRSQGYEDELINAREEAIREMEQRAKDIGANAVIGVDIDYEVLGADNGMLMVTASGTAVVIEAQDY
>NZ_MDMC01000003.1|WP_009930499.1|22924_23599_+|DNA-alkylation-repair-protein
MITFDQLDTELQALENPNTIKIFRNHGCPDSLDLYGLKIGDLKKIIRREKLTKNHELAVKLIESNNSDLIYLGLLAINPNKITTEQIEKWNIAFRETWSQLTFGLASIVSKRDDALLFAKTWIESDYDLTKSMGWQIYSEHINNLPEAETLLQRAKETLQTETNRTRYSMNGFIITCGIYKDDLHEKAMEAAKSVGKVHVNLGNTACKVPDAISYIEKARNRTK
>NZ_MDMC01000003.1|WP_003722739.1|21906_22848_+|L-lactate-dehydrogenase
MKDHQKIILVGDGAVGSSYAFACVNLSIGQEFGIIDIDKDRTIGDAMDLSHAVPFSTPKKIYSANYSDCHDADLVVVTAGTAQKPGETRLDLVNRNIKIMKGIVDEVMASGFDGIFLIASNPVDILTYATWKFSGLPKERVIGSGTSLDTARFRMSIADYLKVDARNVHGYILGEHGDTEFPAWSHTTVGGLPITEWISEDEQGAMDTIFVSVRDAAYEIINKKGATFYGVAAALARITKAILNNENAILPLSVYLDGHYGMNDIYIGAPAVVNRQGVRHIVEMNLNDKEKEQMKNSADTLKKVLDDAMKQID
>NZ_MDMC01000003.1|WP_003722740.1|20989_21613_-|50S-ribosomal-protein-L25/general-stress-protein-Ctc
MATTLEVQKRETTQHSEVTRLRSEGKVPGIIYGYKSENVPVSVDSLELIKAVRDNGRNAVFSVTVDGKKLNVLLHEYQVDPLKDVLVHVDLLAVDMNEEVETDVRVVLVGDAPGVKAGGVLQQIIHDVKVSATPEKLPETIELDISSLEIGDVLTTNDLPENKDYVVQAEEEETVVTVSAPRAEEEPTTTEAPEPEAVHGKDEEPVE
>NZ_MDMC01000003.1|WP_009930501.1|20315_20900_-|GNAT-family-N-acetyltransferase
MLDKSVPHISVIMVNHDATNYPEFHLPAGYSFCFYKDGLEEDWCRLQLETGQVLSMDSIRARFETEFGNEKEKLTKRCIFVKAPNGEIIGTAMLWDGNTFGKIESRIHWVAVLDSHGGKGIAKALLSKILGLNKSKFVYLTTQTGSYQAIYLYRKFGFEKYVGKTPENWKTVNFQEEKETAWQIIENKIAEHQA
>NZ_MDMC01000003.1|WP_003722742.1|19648_20209_-|aminoacyl-tRNA-hydrolase
MKLIAGLGNPGKKYERTRHNVGFMVVDELSFRHQTPWKKSKFNGMTSEIIVGGEKMILVKPLTFMNASGECIRPLMDYYNIPIEDVVIVYDDLDLPVGKIRLRQKGSAGGHNGMKSIIQHVKTQEFNRIRVGVSRPLKGEVINYVLGDFPKAEQPDIIAAIQKSADAIEDFAQTPFIEVMNKYNQK
>NZ_MDMC01000003.1|WP_010989376.1|15994_19534_-|transcription-repair-coupling-factor
MKGLQQLIYEQKDIRAVLNALDEKEKAQLVTGLTGSSRALFASVVEGASKRPVVFVTHNLYHAQKLYDDLLSLMDVDRLFLYPADELISSELSISSPELRGQRVEALDFLLSGKPGIVIVPVAGLRKMLPPVSLWKHFNISIVEGEEIDPDVLRQKLVTMGYTMSGMVNTPGEFSVRGGIIDIYPITEEFPIRIELFDTEVDSLRFFDVETQRSTTRVEEFRLLPATEIILDQSYYPDIVKRLEKKMMLTLNELKEQEDKQALIENLEEDLEMLRSGVKPDMFFKYIGLAYPDPASLFDYLPKNTAILLDEFGRILETEESLEREEAEWQTETLSRMETVRDVQVSHSFKKLLEGNHSPKIYLSLFQKQMASMRVSKTTNIVYKQMQQFHGQMNVLKTELESWHKNNYAVVILAPNLERAEKMQQTLTDYDMESTILKKESDVPKYGMVQFVIGTFQNGFELPLAKVAIISETELFNKKIKKVKKRQKLSNAERIQSYSELKVGDYVVHVNHGIARYVGMETLDINGVHKDYLLLVYQGEDKLFIPVDQLDLVQKYVGAEGKSPRLNKLGGAEWKRVKKKVQASVQDIADDLIKLYAEREAEKGYAFSADDEMQREFEEAFPYQETEDQLRSISEIKKDMERPRPMDRLLVGDVGYGKTEVALRAAFKAIMDGKQVAFLVPTTILAQQHFETMKERFQGFPIEIGLLSRFRTKKQQTETLKGMKNGTVDVVVGTHRLLSKDVEYQDLGLLIVDEEQRFGVTHKEKIKQMRSKIDVLTLTATPIPRTLHMSMLGVRDLSVIETPPANRFPVQTYVAEQNNVLVREAIERELARDGQVYYLYNRVESITQKADEISAMVPDARVATAHGQMGESELESVILSFLEGEFDVLVTTTIIETGVDIPNVNTLFVQDADRMGLSQLYQLRGRVGRWNRIAYAYFMYQKDKILREEAEKRLSAIKEFTELGSGFKIAMRDLSIRGAGNILGAQQHGFIDSVGFDLYSQMLKEAIEAKKPKEEQKQIVPVEIDIQADAYIPEYYITDGRQKIEMYKRFRNIETLSELEDLQSDMIDRFGEYPEEVEYLFTMTELKVRALEVGIESVKQEQNKITMLFSESGTAGIRGDIVMQIIGEFGRMVGVGMEGTQLKITINVQNKPLKEWLYQVKSLAEKLRGAMKEKASTEN
>NZ_MDMC01000003.1|WP_010989373.1|28062_29595_-|zinc-metalloproteinase-Mpl
MKSKLICIIMVIAFQAHFTMTVKADSVGEEKLQNNTQAKKTPADLKALPDSCEAKDFYKNFKILDMTKDKLGVTHYTLALSSGGYLTDNDEIKVHVTPDNKITFINGDLQQGQLRITNQIKITEKNAIEKAFEAIGQSEAHVKSYVGNPVKEKEIILNSRTKRLVYNIKLIFAEPEVASWIVQVDVETGAILKKQNMLSEVERADTHKDFQALGKGANRLLQRPLHVMKINDLFYLVDRTHKGLIRTFDLKHNTDTSFGKVVSNKTNMFTDPEFSSAVDAHFYASEVYEYYKNVHQLESLDGKGGEIDSFVHYGLNCNNAFWDGQEILYGDGDKKNFKPFSCAKTIVGHELTHAVIQYSAGLEYEGQSGALNESFADVFGYFIAPNHWLIGEDVCVRGSRDGRIRSIKDPDKYNQAAHMKDYESLPLTEEGDWGGVHYNSGIPNKAAYNTITKLGKEKTEQLYFRALKYYLTKKSQFTDAKKALQQAAKDLYGEDASKKVAEAWEAVGVN
>NZ_MDMC01000003.1|WP_003722731.1|29925_31515_-|cholesterol-dependent-cytolysin-listeriolysin-O
MKKIMLVFITLILVSLPIAQQTEAKDASAFNKENSISSMAPPASPPASPKTPIEKKHADEIDKYIQGLDYNKNNVLVYHGDAVTNVPPRKGYKDGNEYIVVEKKKKSINQNNADIQVVNAISSLTYPGALVKANSELVENQPDVLPVKRDSLTLSIDLPGMTNQDNKIVVKNATKSNVNNAVNTLVERWNEKYAQAYPNVSAKIDYDDEMAYSESQLIAKFGTAFKAVNNSLNVNFGAISEGKMQEEVISFKQIYYNVNVNEPTRPSRFFGKAVTKEQLQALGVNAENPPAYISSVAYGRQVYLKLSTNSHSTKVKAAFDAAVSGKSVSGDVELTNIIKNSSFKAVIYGGSAKDEVQIIDGNLGDLRDILKKGATFNRETPGVPIAYTTNFLKDNELAVIKNNSEYIETTSKAYTDGKINIDHSGGYVAQFNISWDEVNYDPEGNEIVQHKNWSENNKSKLAHFTSSIYLPGNARNINVYAKECTGLAWEWWRTVIDDRNLPLVKNRNISIWGTTLYPKYSNKVDNPIE
>NZ_MDMC01000003.1|WP_003733144.1|31756_32710_+|phosphatidylinositol-specific-phospholipase-C
MYKNYLQRTLVLLLCFILYFFTFPLGGKAYSLNNWNKPIKNSVTTKQWMSALPDTTNLAALSIPGTHDTMSYNGDITWTLTKPLAQTQTMSLYQQLEAGIRYIDIRAKDNLNIYHGPIFLNASLSGVLETITQFLKKNPKETIIMRLKDEQNSNDSFDYRIQPLINIYKDYFYTTPRTDTSNKIPTLKDVRGKILLLSENHTKKPLVINSRKFGMQFGAPNQVIQDDYNGPSVKTKFKEIVQTAYQASKADNKLFLNHISATSLTFTPRQYAAALNNKVEQFVLNLTSEKVRGLGILIMDFPEKQTIKNIIKNNKFN
>NZ_MDMC01000003.1|WP_003722729.1|32980_33694_+|listeriolysin-O-transcriptional-regulator-PrfA
MNAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNLQYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTLQKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGIAHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN
>NZ_MDMC01000003.1|WP_003722728.1|33736_34693_-|ribose-phosphate-diphosphokinase
MSNEYFDPKLKIFSLNSNRELAEEIAKEVGIELGKSSVTHFSDGEIQINIEESIRGCHVYVIQSTSNPVNQNLMELLIMIDALKRASAATINIVMPYYGYARQDRKARSREPITAKLVANLIETAGATRMITLDMHAPQIQGFFDIPIDHLNAVRLLSDYFSERHLGDDLVVVSPDHGGVTRARKMADRLKAPIAIIDKRRPRPNVAEVMNIVGNVEGKVCIIIDDIIDTAGTITLAAKALREAGATKVYACCSHPVLSGPAMKRIEESPIEKLVVTNSIALPEEKWIDKMEQLSVAALLGEAIVRVHENASVSSLFE
>NZ_MDMC01000003.1|WP_009931068.1|34743_36117_-|bifunctional-UDP-N-acetylglucosamine-diphosphorylase/glucosamine-1-phosphate-N-acetyltransferase-GlmU
MSKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLNVDKVVTIVGHGAEKVQEHLAGKSEFVKQDEQLGTAHAVLQAKAELAGKDGVTLVVCGDTPLIEASTMEALLKYHHEKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDATEKEQRISEINTGTYCFDNKALFEALENVSNDNVQGEYYLPDVIKILKDSDEVVAAYRMESFEESLGVNDRIALAEASKLMQRRINENHMRNGVTLVNPESTYIDIDVKIGQDTVIEPGVMLRGKTVIGDDCVVTSGSEIVNSVIGERVHVRTSSIFESKVGDDVQIGPYAHLRPESDIHDHVKIGNYVETKKAVVGEGTKLPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDNVFVGCNSNLIAPVKVGDRAFIAAGSTITKDVPEDALGIARAKQDNKLGYAKHLNHSK
>NZ_MDMC01000003.1|WP_003722726.1|36503_36812_-|septation-regulator-SpoVG
MQVTDVRLRRVETDGRMRAIASITLDEEFVVHDIRVIDGNNGLFVAMPSKRGVDGEFRDIAHPINSDTRAKIQEVVLAEYERVGEEEATAVTEEESESVSAE
>NZ_MDMC01000003.1|WP_003722725.1|36931_37240_-|septation-regulator-SpoVG
MEITDVRLRRVETDGRMKAISSITIDGEFVIHDIRVIDGNEGLFVAMPSKRTPDGEFRDIAHPINSGTRAKIQEAVLAAYEVADEPAVNEESSADESIVEEN
>NZ_MDMC01000003.1|WP_009931069.1|37924_39133_-|ABC-transporter-permease
MNVLQSMKMAWKQLKASKLRSFLTMLGIIIGVASVILLVSLGNGVTQEVDDQMGDLGSNLITVVNSSVNPNDKYTYDEVMKYQNIDGVKSVSPELSGQVNATFDYKNSSNKVIGTNDQYKAARSLEMKEGRFLLPIDTEYGQKVAVIGSTVASDLFGFGDPIGETIRLNGMPYKVVGVLKEKGASMMGSSDDQIFIPISSAQRLLKDTNVRTIYVETKSAEDVDFVVNTLESRLAIKFGDEKEQEKNASSAQMGPSYQVINQQEILNAFNTISTTLTTALGAIAAISLVVGGIGIMNIMLVSVSERTREIGIRKALGAKKRAILLQFLIESIVISVCGGVIGIIIGVSGALIFGSVAGISSGITAGTIIFSFVFSLCIGVIFGIAPANKASKLRPIDALRSE
>NZ_MDMC01000003.1|WP_003722723.1|39129_39822_-|ABC-transporter-ATP-binding-protein
MPKPLIDMKNLTKTYTLGGETFKALDDVTFTVEQGEFLSIVGPSGSGKSTLMNMIGCLDVPDEGSYHLDDVDVFKLSDNKLSEIRNKKIGFIFQQFNLLPKLSAFENVELPLIYAGLSVSAREKAAIECLEKVGLLEKRRNLPTQLSGGQQQRVAIARALAGKPQILLADEPTGALDSKTGKEVMGILQELNRAGNTIVMITHDPTIASYGTRSIRIQDGKLFHEEATQA

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

4. NZ_MDMC01000005

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

113293 : 172344

Listeria_phage(84.62%)

integrase,portal,terminase,holin,tail,capsid,plate

attL 132732:132751|attR 171789:171808

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003722616.1\|113293_113647_+\|holin	phage holin family protein	NA	NA	NA	NA
WP_003722615.1\|113833_114772_+	HPr kinase/phosphorylase	NA	NA	NA	NA
WP_003722614.1\|114857_115691_+	prolipoprotein diacylglyceryl transferase	NA	NA	NA	NA
WP_003722613.1\|115734_116388_+	pyrophosphatase PpaX	NA	NA	NA	NA
WP_003722612.1\|116391_116889_+	acyltransferase	NA	NA	NA	NA
WP_009930948.1\|116974_118450_+	hypothetical protein	NA	NA	NA	NA
WP_003722610.1\|118528_119488_+	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.0e-88	53.7
WP_009924988.1\|119606_120590_+	UDP-glucose 4-epimerase GalE	A0A2K9L5H6	Tupanvirus	3.1e-52	38.4
WP_009930954.1\|120606_121668_+	galactose mutarotase	NA	NA	NA	NA
WP_010990002.1\|121709_123440_+	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	1.3e-175	54.0
WP_010990001.1\|123547_124423_+	RNase adapter RapZ	A0A0R8VB27	Thermobifida_phage	3.2e-08	29.7
WP_003722605.1\|124424_125393_+	YvcK family protein	A1IMD5	Streptococcus_phage	6.7e-68	43.3
WP_003722604.1\|125400_126372_+	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	5.2e-52	39.4
WP_003732493.1\|126398_127415_+	NADPH dehydrogenase NamA	NA	NA	NA	NA
WP_010990000.1\|127468_128635_-	class 3 internalin InlP	NA	NA	NA	NA
WP_003732491.1\|128852_130244_+	amino acid permease	NA	NA	NA	NA
WP_003722600.1\|130291_130888_-	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	A0A223W000	Agrobacterium_phage	6.6e-58	57.4
WP_060562976.1\|131044_132481_+	polysaccharide monooxygenase	A0A0K1Y848	Apis_mellifera_filamentous_virus	4.0e-24	35.8
132732:132751	attL	NA	NA	NA	NA
WP_009924235.1\|132756_133887_-\|integrase	site-specific integrase	A8ATX2	Listeria_phage	1.7e-208	98.1
WP_009924234.1\|133951_134602_-	hypothetical protein	NA	NA	NA	NA
WP_009924233.1\|134656_134824_-	hypothetical protein	NA	NA	NA	NA
WP_009924232.1\|134980_135457_-	XRE family transcriptional regulator	A8ASM2	Listeria_phage	1.4e-39	59.9
WP_009924231.1\|135625_135829_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_009924230.1\|135861_136050_+	hypothetical protein	NA	NA	NA	NA
WP_009924229.1\|136060_136834_+	Rha family transcriptional regulator	R9QMT9	Lactococcus_phage	1.5e-38	40.3
WP_009924228.1\|136956_137481_+	hypothetical protein	A8ATY1	Listeria_phage	3.5e-87	98.3
WP_003731810.1\|137487_137724_+	DUF771 domain-containing protein	A8ATY2	Listeria_phage	1.9e-40	100.0
WP_003731809.1\|137831_138020_+	hypothetical protein	A8ATY3	Listeria_phage	4.5e-29	100.0
WP_003731808.1\|138252_139212_+	YqaJ viral recombinase family protein	A8ATY5	Listeria_phage	1.5e-176	98.4
WP_010991173.1\|139211_140027_+	recombinase RecT	A8ATY6	Listeria_phage	3.5e-150	98.9
WP_046336554.1\|140046_140979_+	DnaD domain-containing protein	A8ATY7	Listeria_phage	3.9e-166	98.4
WP_003722560.1\|140975_141788_+	DNA adenine methylase	Q8W5X3	Listeria_phage	4.8e-152	95.6
WP_046336551.1\|141784_142381_+	DUF1642 domain-containing protein	A8ATY9	Listeria_phage	4.6e-43	50.5
WP_046336549.1\|142377_142557_+	hypothetical protein	A0A059T5G0	Listeria_phage	3.2e-24	94.9
WP_057171520.1\|142553_142976_+	hypothetical protein	A0A059T7V5	Listeria_phage	2.8e-34	69.1
WP_045552924.1\|142975_143245_+	hypothetical protein	A0A059T7S7	Listeria_phage	3.3e-33	79.1
WP_003731703.1\|143241_143418_+	hypothetical protein	A0A076G7F4	Listeria_phage	1.9e-21	87.9
WP_172426257.1\|143447_143603_+	hypothetical protein	A0A059T654	Listeria_phage	4.4e-22	94.1
WP_061684869.1\|143599_143788_+	hypothetical protein	NA	NA	NA	NA
WP_069001033.1\|143787_144036_+	hypothetical protein	A8ATZ5	Listeria_phage	4.4e-08	93.1
WP_046336535.1\|144032_144515_+	single-stranded DNA-binding protein	A8ATZ7	Listeria_phage	1.3e-80	98.1
WP_003731709.1\|144533_144716_+	hypothetical protein	A8ASP6	Listeria_phage	3.8e-17	79.4
WP_046336533.1\|144660_145065_+	DUF1064 domain-containing protein	A8ASP7	Listeria_phage	3.1e-59	87.3
WP_046336531.1\|145068_145452_+	DUF2481 family protein	A8ASP8	Listeria_phage	9.7e-63	96.1
WP_003744979.1\|145592_145748_+	hypothetical protein	A0A0B5D186	Listeria_phage	6.7e-23	100.0
WP_046336529.1\|145835_146408_+	sigma-70 family RNA polymerase sigma factor	A0A0B5D145	Listeria_phage	1.2e-88	87.4
WP_003734122.1\|146643_147183_+	hypothetical protein	NA	NA	NA	NA
WP_046336528.1\|147228_148023_+\|terminase	terminase small subunit	A8ASJ1	Listeria_phage	1.6e-11	70.4
WP_010989956.1\|147991_149323_+\|terminase	PBSX family phage terminase large subunit	Q9T1C1	Listeria_phage	1.1e-259	98.0
WP_009925050.1\|149335_151105_+\|portal	phage portal protein	A8ASJ3	Listeria_phage	5.0e-263	91.0
WP_046336524.1\|151105_152245_+\|capsid	phage minor capsid protein	A8ASJ4	Listeria_phage	3.9e-200	96.0
WP_010990217.1\|152323_152893_+	phage scaffolding protein	Q9T1B8	Listeria_phage	7.4e-91	97.4
WP_021496950.1\|152916_153816_+\|capsid	phage major capsid protein	A0A0B5CU19	Listeria_phage	9.0e-168	100.0
WP_074046915.1\|153815_153974_+	hypothetical protein	Q9T1B6	Listeria_phage	5.1e-18	96.2
WP_031644583.1\|153975_154371_+	hypothetical protein	A8ASJ8	Listeria_phage	8.2e-65	96.2
WP_031644585.1\|154370_154733_+	hypothetical protein	Q9T1B4	Listeria_phage	4.1e-63	97.5
WP_031644586.1\|154732_155071_+\|capsid	minor capsid protein	Q9T1B3	Listeria_phage	8.3e-58	99.1
WP_010679811.1\|155070_155478_+	hypothetical protein	A0A0B5CU21	Listeria_phage	1.2e-66	98.5
WP_031644589.1\|155480_155918_+	hypothetical protein	A0A0B5CYN3	Listeria_phage	1.2e-77	99.3
WP_031644591.1\|155847_156180_+	Ig-like domain-containing protein	Q9T1B0	Listeria_phage	4.1e-49	98.2
WP_031644594.1\|156234_156657_+\|tail	phage tail assembly chaperone	Q9T1A9	Listeria_phage	2.0e-69	99.3
WP_031644596.1\|156662_157262_+	bacteriophage Gp15 family protein	A0A0B5CTW0	Listeria_phage	8.1e-72	68.0
WP_069002794.1\|157277_162641_+	tape measure protein	A0A0B5CU25	Listeria_phage	0.0e+00	82.2
WP_031644600.1\|162642_163461_+\|tail	phage tail family protein	Q9T1A6	Listeria_phage	3.6e-147	92.3
WP_003722528.1\|163469_164495_+\|tail	phage tail protein	Q9T1A5	Listeria_phage	4.3e-198	98.2
WP_003722527.1\|164495_165524_+	hypothetical protein	Q9T1A4	Listeria_phage	4.6e-192	100.0
WP_003722526.1\|165523_166597_+\|plate	phage baseplate upper protein	Q9T1A3	Listeria_phage	4.5e-198	100.0
WP_003722525.1\|166608_166926_+	hypothetical protein	Q9T1A2	Listeria_phage	6.2e-55	100.0
WP_003722524.1\|166930_167089_+	hypothetical protein	Q9T1A1	Listeria_phage	6.0e-19	100.0
WP_014601069.1\|167117_167483_+	hypothetical protein	Q9T1A0	Listeria_phage	3.7e-11	97.9
WP_003722522.1\|167495_167777_+\|holin	holin	A8ASL4	Listeria_phage	3.4e-41	94.6
WP_046336514.1\|167776_168484_+	M15 family metallopeptidase	A8ATW4	Listeria_phage	1.8e-126	96.2
WP_031645776.1\|168722_168902_+	hypothetical protein	A0A0B5CU31	Listeria_phage	3.5e-23	96.6
WP_031645777.1\|168901_169441_+	GNAT family N-acetyltransferase	A0A0B5CYP1	Listeria_phage	1.5e-77	79.2
WP_039381651.1\|169533_170031_-	AP2 domain-containing protein	A8ATW6	Listeria_phage	1.9e-90	99.4
WP_003722518.1\|170055_170505_-	anti-CRISPR protein AcrIIA1	A8ATW7	Listeria_phage	2.4e-76	100.0
WP_003731276.1\|170505_170757_-	hypothetical protein	A8ATW8	Listeria_phage	2.0e-40	100.0
WP_003731277.1\|170788_171022_-	hypothetical protein	A8ATW9	Listeria_phage	4.3e-13	100.0
WP_046336509.1\|171323_171557_+	hypothetical protein	A0A059T6E1	Listeria_phage	2.3e-35	96.1
WP_052713350.1\|171553_171757_+	hypothetical protein	A8ATX1	Listeria_phage	9.1e-28	85.1
WP_003722598.1\|172008_172344_-	membrane protein	S5MNN8	Brevibacillus_phage	6.0e-16	76.6
171789:171808	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr_ID: NZ_MDMC01000005.1|WP_003731276.1|170505_170757_-|hypothetical-protein

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Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_MDMC01000005.1|WP_003731276.1|170505_170757_-|hypothetical-protein

170505_170757_-

83 aa aa

AcrIIA12

hit_Aca_id	identity	query_coverage	hit_coverage
anti_CRISPR3641\|WP_003731276.1\|AcrIIA12\|II-A\|Verified\|Listeria-monocytogenes	1.0	1	1.0

113293-172344

5. NZ_MDMC01000002

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

26190 : 35273

Streptococcus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003728469.1\|26190_29106_-\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	1.9e-174	36.7
WP_003728468.1\|29109_29664_-	recombinase family protein	A0A0F7LA37	Escherichia_phage	7.0e-38	53.4
WP_003728467.1\|29943_30303_+	Cd(II)-sensing metalloregulatory transcriptional repressor CadC	E4ZFI8	Streptococcus_phage	3.1e-26	50.0
WP_003728466.1\|30302_32438_+	cadmium-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.6e-247	64.5
WP_012952127.1\|32929_33475_+	YdhK family protein	NA	NA	NA	NA
WP_003728511.1\|33850_34459_+	recombinase family protein	A0A1W5LU24	Ralstonia_phage	1.0e-21	42.9
WP_003728510.1\|34448_34676_+	hypothetical protein	NA	NA	NA	NA
WP_003731679.1\|34795_35074_-	hypothetical protein	NA	NA	NA	NA
WP_003728509.1\|35036_35273_+	helix-turn-helix transcriptional regulator	A0A097PBE6	Streptococcus_pyogenes_phage	6.7e-14	53.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

6. NZ_MDMC01000008

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CRISPR-Cas detection and classification

Crispr_ID: NZ_MDMC01000008_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_MDMC01000008_1

309759-310047

Orphan

I-A

Consensus_repeat	Method
ATTTACATTTCACAATAAGTAACTAAAAC	PILER-CR
ATTTACATTTCACAATAAGTAACTAAAAC	CRISPRCasFinder
ATTTACATTTCACAATAAGTAACTAAAAC	CRT

4 spacers

The CRISPR arrays of NZ_MDMC01000008_1

>merge|NZ_MDMC01000008|1|309759-310047|PILER-CR,CRISPRCasFinder,CRT
ATTTATATTTCACAATAAGTAACTAAAACGCTTTGGTGGTATTGAGTGTAGGGACTTTGGTGGTAAATTTACATTTCACAATAAGTAACTAAAACTTGTAACCCATCGCTGTCCCTTTGACAAAAATCGCATTTACATTTCACAATAAGTAACTAAAACGCTACATGCTTGATGTGCTTTACACAAAAGAGAGCAATTTACATTTCACAATAAGTAACTAAAACTAAATTGCAAATAAATTACTAATATCTTTTTTATCGATTTACATTTCACAATAAGTAACTAAAAC

>NZ_MDMC01000008|1|1|309759-310047|PILER-CR
ATTTATATTTCACAATAAGTAACTAAAAC	GCTTTGGTGGTATTGAGTGTAGGGACTTTGGTGGTAA
ATTTACATTTCACAATAAGTAACTAAAAC	TTGTAACCCATCGCTGTCCCTTTGACAAAAATCGC
ATTTACATTTCACAATAAGTAACTAAAAC	GCTACATGCTTGATGTGCTTTACACAAAAGAGAGCA
ATTTACATTTCACAATAAGTAACTAAAAC	TAAATTGCAAATAAATTACTAATATCTTTTTTATCG
ATTTACATTTCACAATAAGTAACTAAAAC

>NZ_MDMC01000008|1|1|309759-310047|CRISPRCasFinder
ATTTATATTTCACAATAAGTAACTAAAAC	GCTTTGGTGGTATTGAGTGTAGGGACTTTGGTGGTAA
ATTTACATTTCACAATAAGTAACTAAAAC	TTGTAACCCATCGCTGTCCCTTTGACAAAAATCGC
ATTTACATTTCACAATAAGTAACTAAAAC	GCTACATGCTTGATGTGCTTTACACAAAAGAGAGCA
ATTTACATTTCACAATAAGTAACTAAAAC	TAAATTGCAAATAAATTACTAATATCTTTTTTATCG
ATTTACATTTCACAATAAGTAACTAAAAC

>NZ_MDMC01000008|1|1|309759-310047|CRT
ATTTATATTTCACAATAAGTAACTAAAAC	GCTTTGGTGGTATTGAGTGTAGGGACTTTGGTGGTAA
ATTTACATTTCACAATAAGTAACTAAAAC	TTGTAACCCATCGCTGTCCCTTTGACAAAAATCGC
ATTTACATTTCACAATAAGTAACTAAAAC	GCTACATGCTTGATGTGCTTTACACAAAAGAGAGCA
ATTTACATTTCACAATAAGTAACTAAAAC	TAAATTGCAAATAAATTACTAATATCTTTTTTATCG
ATTTACATTTCACAATAAGTAACTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_MDMC01000008.1\|WP_010989500.1\|305084_306902_-\|lmo0514-family-class-1-internalin	unknown	unknown	gnl\|CDD\|380190
NZ_MDMC01000008.1\|WP_003721293.1\|312645_312939_-\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
NZ_MDMC01000008.1\|WP_003733190.1\|310284_311220_-\|ribose-phosphate-pyrophosphokinase	unknown	unknown	gnl\|CDD\|234929
NZ_MDMC01000008.1\|WP_003721290.1\|314658_315057_-\|hypothetical-protein	unknown	unknown	unknown
NZ_MDMC01000008.1\|WP_010989496.1\|319002_319671_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NZ_MDMC01000008.1\|WP_003733191.1\|315073_315541_-\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129
NZ_MDMC01000008.1\|WP_009932856.1\|307283_307742_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378956
NZ_MDMC01000008.1\|WP_003721301.1\|304552_304984_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
NZ_MDMC01000008.1\|WP_069002832.1\|303075_304506_+\|CapA-family-protein	unknown	unknown	gnl\|CDD\|225399
NZ_MDMC01000008.1\|WP_003727296.1\|301490_301859_+\|DUF1304-domain-containing-protein	unknown	unknown	gnl\|CDD\|226282
NZ_MDMC01000008.1\|WP_009930756.1\|312954_314001_-\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198
NZ_MDMC01000008.1\|WP_003721294.1\|311359_312631_-\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
NZ_MDMC01000008.1\|WP_003721303.1\|302139_302955_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
NZ_MDMC01000008.1\|WP_010989499.1\|308132_308813_-\|type-1-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|153212
NZ_MDMC01000008.1\|WP_009931218.1\|299928_301344_-\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|129794
NZ_MDMC01000008.1\|WP_003721291.1\|313997_314648_-\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
NZ_MDMC01000008.1\|WP_003721298.1\|307748_308108_+\|Lin0512-family-protein	unknown	unknown	gnl\|CDD\|131113
NZ_MDMC01000008.1\|WP_003733192.1\|315568_316171_-\|SIS-domain-containing-protein	unknown	unknown	gnl\|CDD\|223865
NZ_MDMC01000008.1\|WP_010989497.1\|318345_318996_-\|transaldolase	unknown	unknown	gnl\|CDD\|223254
NZ_MDMC01000008.1\|WP_009930754.1\|308920_309499_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_MDMC01000008.1\|WP_010989500.1\|305084_306902_-\|lmo0514-family-class-1-internalin	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	1.81836e-118
NZ_MDMC01000008.1\|WP_003721293.1\|312645_312939_-\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	3.06007e-27
NZ_MDMC01000008.1\|WP_003733190.1\|310284_311220_-\|ribose-phosphate-pyrophosphokinase	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	1.26262e-153
NZ_MDMC01000008.1\|WP_010989496.1\|319002_319671_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	9.1314e-90
NZ_MDMC01000008.1\|WP_003733191.1\|315073_315541_-\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	2.76446e-37
NZ_MDMC01000008.1\|WP_003721301.1\|304552_304984_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.03126e-27
NZ_MDMC01000008.1\|WP_069002832.1\|303075_304506_+\|CapA-family-protein	gnl\|CDD\|225399	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane].	1.49005e-100
NZ_MDMC01000008.1\|WP_003727296.1\|301490_301859_+\|DUF1304-domain-containing-protein	gnl\|CDD\|226282	COG3759, COG3759, Predicted membrane protein [Function unknown].	2.33548e-41
NZ_MDMC01000008.1\|WP_009930756.1\|312954_314001_-\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	0
NZ_MDMC01000008.1\|WP_003721294.1\|311359_312631_-\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	7.01085e-178
NZ_MDMC01000008.1\|WP_003721303.1\|302139_302955_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.01016e-50
NZ_MDMC01000008.1\|WP_010989499.1\|308132_308813_-\|type-1-glutamine-amidotransferase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	9.06055e-60
NZ_MDMC01000008.1\|WP_009931218.1\|299928_301344_-\|multidrug-efflux-MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.18163e-80
NZ_MDMC01000008.1\|WP_003721291.1\|313997_314648_-\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	4.74405e-108
NZ_MDMC01000008.1\|WP_009932856.1\|307283_307742_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	9.15558e-13
NZ_MDMC01000008.1\|WP_003733192.1\|315568_316171_-\|SIS-domain-containing-protein	gnl\|CDD\|223865	COG0794, GutQ, Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane].	1.15952e-75
NZ_MDMC01000008.1\|WP_010989497.1\|318345_318996_-\|transaldolase	gnl\|CDD\|223254	COG0176, MipB, Transaldolase [Carbohydrate transport and metabolism].	5.85703e-62
NZ_MDMC01000008.1\|WP_003721298.1\|307748_308108_+\|Lin0512-family-protein	gnl\|CDD\|131113	TIGR02058, lin0512_fam, conserved hypothetical protein. This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N-terminus. [Hypothetical proteins, Conserved].	5.62162e-67

>NZ_MDMC01000008.1|WP_009930754.1|308920_309499_-|hypothetical-protein
MKKILVPILLLATILASCSSPNEKITKDTKISKTITIRADYKVPKDIKELEDDSANIVKVKFLQNKTIGKDGSTISEIEILTSYKGNLEKGSKVDISEPWYLSDGKYVAVENYIALDKEQEYTIFLGEKDKDTYPLSSLGYGKFGGSLKEDQAVLADFNILGEVQKFDFISENTEEVKNYQLIKEQVAGKYK
>NZ_MDMC01000008.1|WP_010989499.1|308132_308813_-|type-1-glutamine-amidotransferase
MIIDVLQHVPHEGPGLIANWARENQHQLKIHSLFEENAHVPNDSDFLIVLGGPMGINDTAEFPWLKDERKLIKRLSEQHKPVFGVCLGAQQIAATFGSEITVNKEKEVGWFPVKRTSDKLLFFPKSLNVFHWHQDTFALPTGSTRLFASEGCLNQAFLYGENIIGLQFHFEMEKAGIETILRIDEAFITPGKYVQSVEVMREKDVPEDNKQMLEAILDYLINPKTI
>NZ_MDMC01000008.1|WP_003721298.1|307748_308108_+|Lin0512-family-protein
MEQILFIQTGFGVDVHGQNITKAAERAVRNAIFTNSMPGIQGLLPDGDLQNMVVNIKLALPCDADQLDEDTIRAIIPYGTVTIEKMAGGMMTTSGIFLEDKEDKNDLMYIVNASVETGY
>NZ_MDMC01000008.1|WP_009932856.1|307283_307742_+|MarR-family-transcriptional-regulator
MNNEQNMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERELLTIEQGRRDKRQRCIFLTSAGKELENELGAAQRKQMSEIFTNSADTDGMHFTEVMEGYAKNRPGAAFIKDFKE
>NZ_MDMC01000008.1|WP_010989500.1|305084_306902_-|lmo0514-family-class-1-internalin
MKKALKLFLATICMFIMIYPSTAAHAEETNIVNIPDANLKTYLNGLLKQASDAPITKTQMNTIQTVTLSGSTYTDLTGLEEAGNLVTLSLNNTNIQTLEPIKNQTSLTYLTVGGDNVKDSLFVDLNGLVNLQSLSINGSEVTHNVFKTFNKLPKLTYLYAQNSMKITDISALASLPALTTLFLQFDGIDDFRPLNDFESFKNGNLKALAAFGQNTGRTNPRITLKSGKLDYNETNQTLYLPFSMMPKPLTSFDGTVAPFSKSTSASNTYLGFNDVALPSSRLSITDDGITVSGVTKEEFDNLDEIEYNARYDFPTGSYPTPPSMTSYTISSGTYDQYFDISHTLDLTADESFDYNQYDTTSEEQFLKDVHAETDDGTAVKSDFDQVVKLDVPGEYTVTLNAENAAGLKATPVTVKVTVHEKPVITSDSQISYKKETTKSVDEFLKEIHGSVTGNAVLTSDFDKVVDLNTPGEYTVTLNAINDRGQKADPVTVVVTVTTSDSGHVDPVPPTPQEETDQTIIPEPQSETTEDSVKEDQAKDGQAKSEEKADKTSLTTKENKVEKSEKTNQPKTKALPQTGDTNKTALPIAGVMLSLAALLIFRKSKS
>NZ_MDMC01000008.1|WP_003721301.1|304552_304984_-|universal-stress-protein
MEKYHRILVAVDGSEPAKLAFEKGLELALKLDGVLGIASIVDLRAFSPNVSYDGSLEEKAELELKTSVNEYAEKARTAGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>NZ_MDMC01000008.1|WP_069002832.1|303075_304506_+|CapA-family-protein
MKKLTYVIITGLVLVFIAGAFWITNSTNQSDQKATQTEPIKKISPANVKTISSEAKKTLNSLASSGADKASISDLKQLIKELKSYPTEKNDSGVYLQNLTACLEAVKSYTTGKADEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTIINAESAFTNATKAENKMWRIKSDPAHVAFLPASGVDAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNADAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDVKKYKKEDTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKDISIIPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
>NZ_MDMC01000008.1|WP_003721303.1|302139_302955_+|histidine-phosphatase-family-protein
MKKNIFKLLMALCAVLLIAGCGNSTSADKKETKETKEDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVKSAGKGLKDVDFSAAYSSDSGRAIQTANLILKESDKSADKEVQTDPRFREFNFGSYEGDLNENMWTDIAKSQGKTLEEWQKAGLSPKDFANSVAALDKTRVKEGENWPAEDYATIQARLKEGLTDVAKKESKNGDSNVLLVSHGLSIGALLDTIEPGYKLPAEGIKNASVTKITYKDGKFTIGDVNDLSYVEKGSK
>NZ_MDMC01000008.1|WP_003727296.1|301490_301859_+|DUF1304-domain-containing-protein
MAILAFILTFIVMIEHIYIMILEMFFANTKLAAKTFGVEKELLANKKVQTLFANQGLYNGFLAAGLVWGLFFAGAGFAETVQIFFLSCVVVAALFGGATSSKGILVKQGLPAVLALVAVLLV
>NZ_MDMC01000008.1|WP_009931218.1|299928_301344_-|multidrug-efflux-MFS-transporter
MQQEATGGQKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAALSPTFAMLMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGMKFMQNVSVVTKPKIDILSIILSTLGFGGVVFAFSSAGESGWGSATVLVSIIVGGIALGLFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVVALFFLTRIEVGTSALTIIVLHSVLMIGISMVMMPAQTNGLNQLPPKLYPDGTAIMNTLQQVSGAIGTAVAITIMSAGQKAYMETAQGVGPEQMVASLTAGIQNAFVFGLIMACIGLLCSLFIRKAK
>NZ_MDMC01000008.1|WP_003733190.1|310284_311220_-|ribose-phosphate-pyrophosphokinase
MAGKMKLFSVTSERPLATKIADYLDIPLCEVELQKFSDGEVKINIEESIRGTNAYVVQSMNSNVNERLMELLIMVDALKRASVHSINIIMPYYGYARQDRKARSREPITAKLMANLIQRAGANRLITVDLHAAQIQGFFNIPIDHLSAIPLIGDYLIENYGEKDVVVVAPDHSGVVRARRIADRLNAPIAILNRKPRPHEDEIMSVIGDVKGKVAIVVDDIIDTGVRATTSADILLEKGAVEVIACATHSVMAGNATERLQNSNIKEVITSDSIDLPEDKQFDKLTTISIGRILGRAIEGVQENRSLHPLF
>NZ_MDMC01000008.1|WP_003721294.1|311359_312631_-|PTS-galactitol-transporter-subunit-IIC
MDIILDFFKYIIGLGVTVMMPIIITILGVIFRKKISVAFKAGLTVGVGFVGLGVITSLMLTTITPVTKALVENYNFKLTATDIGWGVGSSLAWGTEVVPFVFVAIIATNILMIAFKWTKTMDVDIWNYWQPLFIASALYLTTGSMIIAVLSSIINMAIIFKIADWTQKDVEDVLGLEGISLPQIQTTGWALVGYPMNWLLGKIPGVRKINWSTEKVQSRLGIFGEPMLMGLIIGGGLAAIAQMPLSQVLQTGVTIAASLVLIPRMVSLLMDGLTVISEAAHEFMEKRFPGRELFIGLDSAVGIGHPFVLSLGLLMIPITLILAFILPGNKVLPLADLTALPFYMIFAIVPSKGNLFRGIFTGIVIVIITLYLSGAAAPLMTELAGQIGYNIPKDAVEVTSLAVGTQWYTWIVYYGLHWFGGIL
>NZ_MDMC01000008.1|WP_003721293.1|312645_312939_-|PTS-sugar-transporter-subunit-IIB
MKKKRIYVCCGTGIATSTVISKKVRAVLDEKRIPYEISQCTVQEVASKVSTSKPDIIVSSTTVTGDVGDVPVVIGRSFLTGLKKQETIDEILAILQD
>NZ_MDMC01000008.1|WP_009930756.1|312954_314001_-|galactitol-1-phosphate-5-dehydrogenase
MKALKLYGKRDLRYEEADMPTIEEPDDVILKVKTVGICGSDISRYSKLGPYVPGMVWGHEFSGEVIEVGSEVTDIEIGDRAAGCPALYCGECEYCKKGEFARCRKLTVIGARHPGAYAEYIKLPAENVVKIPNELDYEAAALVEPSAVVVHGFYHTKLQAGDDVVVVGSGNIGLLAIQWAKVFGARRVIAIDVDDKKLALAKEVGADVVINSLKEDPLEVVAAHTDGLNADLVVEAAGSPITSAQVFAYAKKGGGVVFLGIPYADVTIERFYFEKIVRSELTVWGSWNAISAPFPGKEWQTTIHFLANKQINIEPMITHRLSLAEGPEVFERIYERNEFFGKVLFFPE
>NZ_MDMC01000008.1|WP_003721291.1|313997_314648_-|ribulose-phosphate-3-epimerase
MAKIVPSVFGADIGRINEQLQVLEKNDIDLLHVDMMDGSFVPNIAFGPDQIKMMKKGTKLQFDVHMMVYEPDRYIPRLVEAGAHMITVHQEATTHLHRTIQLIKSYGVRAGVVLNPGTPPSTLEYVLDDIDCILLMTVNPGLGGQKFFQSSLEKIRKTKAYIGNRPIQIEVDGGVNDELAKECTLAGADLIVVGSYLFEGDIEANLEKLAKGVLTE
>NZ_MDMC01000008.1|WP_003721290.1|314658_315057_-|hypothetical-protein
MGSFFASFVDWLIGSPGRFVVNLIEDNMLIFMVVVMIYATTILYAKWTLAYYLPKKMSQLAEMKTWELDELYAAWQTEKKALPWYILVPSRNEFWVKSARNAPESTKLLHFSQQKLKLSDKEKLQKIIEIQS
>NZ_MDMC01000008.1|WP_003733191.1|315073_315541_-|PTS-sugar-transporter-subunit-IIA
MDVLEYFKEEMVRFSNEQNKEKLLAEMAEQLCEVGAVKPSYKDAVIKREKVFPTGLLTAHAGVAIPHTDSEHVIRPVVAVRILKKPVSFIEMASDNEAIDVRIVFMMALRSADEQLDMLQTLIQLIQDEEVMTTLLKAQETGDVLSAIEHFSKNN
>NZ_MDMC01000008.1|WP_003733192.1|315568_316171_-|SIS-domain-containing-protein
MDKQAILNNIHQTWQEEANAISRLPEVTSEEALVKTVEKIAECTGKIVVAGCGTSGVAAKKLVHSFNCIERPAVFLTPSDAVHGTLGVLQKEDILILISKGGNTGELLNLIPACKTKGSTLIGVTENPDSVIAKEADIFFPVSVSKEPDPFNMLATASTMAVIASFDAVIVCLMTYMNYTKEQFSVIHPGGAVGNKLLNK
>NZ_MDMC01000008.1|WP_010989497.1|318345_318996_-|transaldolase
MHLDSANLDDVKKIQASSIFKGITTNPTILVKEKCNRQTAINRILELTDKQVFVQTVGFTYEEILADARMLLTMFGKDKIAIKIPAHEAGTNVIDTLKKEDKTIQILGTAIYSADQAITAALAGADFVAPYVNRMSAANIDPFKEITQMRHFFDKKALKTQIMAASFKHSGQVMQAYESGADTVTIPYEIYSQMTNKVLAVEAIRVFNEDAVLYEK
>NZ_MDMC01000008.1|WP_010989496.1|319002_319671_-|ribulose-phosphate-3-epimerase
MKMIAASIMCADSLHLADELRALEQANVKMLHCDVMDGVFVENAAMGAYVLQDIKNNTKMLLDIHLATVNPDKFVDLYAAIKPAYMSFHLEASRDVNATINHIRELGIRPSIAISPDTEIEQIYPFLGKVDMVLMMTVNPGFAGQKFQHHVLEKIKKLQKELESHTNKPLIEVDGNIFEETVRLLEPIGADVYVVGTAALFNEKAGSYTEKLAPLREIIQER

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Crispr_ID: NZ_MDMC01000008_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_MDMC01000008_2

355012-355596

Orphan

Consensus_repeat	Method
CATATNAGTTACTGAACTNGTATCAAAATNACTTACATC	CRT

7 spacers

The CRISPR arrays of NZ_MDMC01000008_2

>merge|NZ_MDMC01000008|2|355012-355596|CRT
CATGTTAGTCACTGAACTGGTATCAAAGGTACTTAAATCAAGCTTCTCCACTTTTTCATTATCAGAAAACATGGCAGCCATATTAGTTACTGAACTCGTATCAAAATTACTTACATCTAACGCTTCAAGACTAGTACAACCAGCAAACATGGCACGCATATCAGTTACTAAGCTCGTATTAAAATTACTTACATCCAACTTCTCAAGGGCGCTACAATTTCTAAACATTTGAACCATTGCAGTAGCGGAACTGGTATCGAAATTACTTACATCTAGTTTCTTCAGTTTTTCACAGCCATTAAACACTCTATACATATCAGTTACTGAACTCGTATCAAAATGACTTACATCCAGCTCTTCAAGACTAGTACAATCTTCAAACATGGCATACATATTAGTTACTGAACTGGTATCAAGGTTGCTTACATCCAGCACCTCAAGATTTCTATTATCATAAAACATGTAAGACATATTAGTTACTGAACTTGTATCAAAATGACTTACATCCAGTTCCTCAAGTGCCCTACAGCTGTTAAACATATCCCACATAGTAGTTACCGCACTAGTATCAAGACCACTCAAATC

>NZ_MDMC01000008|2|2|355012-355596|CRT
CATGTTAGTCACTGAACTGGTATCAAAGGTACTTAAATC	AAGCTTCTCCACTTTTTCATTATCAGAAAACATGGCAGC
CATATTAGTTACTGAACTCGTATCAAAATTACTTACATC	TAACGCTTCAAGACTAGTACAACCAGCAAACATGGCACG
CATATCAGTTACTAAGCTCGTATTAAAATTACTTACATC	CAACTTCTCAAGGGCGCTACAATTTCTAAACATTTGAAC
CATTGCAGTAGCGGAACTGGTATCGAAATTACTTACATC	TAGTTTCTTCAGTTTTTCACAGCCATTAAACACTCTATA
CATATCAGTTACTGAACTCGTATCAAAATGACTTACATC	CAGCTCTTCAAGACTAGTACAATCTTCAAACATGGCATA
CATATTAGTTACTGAACTGGTATCAAGGTTGCTTACATC	CAGCACCTCAAGATTTCTATTATCATAAAACATGTAAGA
CATATTAGTTACTGAACTTGTATCAAAATGACTTACATC	CAGTTCCTCAAGTGCCCTACAGCTGTTAAACATATCCCA
CATAGTAGTTACCGCACTAGTATCAAGACCACTCAAATC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_MDMC01000008.1\|WP_003721255.1\|352464_352731_-\|transposase	unknown	unknown	unknown
NZ_MDMC01000008.1\|WP_009931584.1\|353139_353625_-\|hypothetical-protein	unknown	unknown	unknown
NZ_MDMC01000008.1\|WP_010989480.1\|349146_349452_-\|hypothetical-protein	unknown	unknown	unknown
NZ_MDMC01000008.1\|WP_009930717.1\|369048_369804_+\|DUF4866-domain-containing-protein	unknown	unknown	gnl\|CDD\|379782
NZ_MDMC01000008.1\|WP_010989475.1\|362923_364519_-\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225306
NZ_MDMC01000008.1\|WP_010989473.1\|365626_366775_+\|DUF58-domain-containing-protein	unknown	unknown	gnl\|CDD\|224635
NZ_MDMC01000008.1\|WP_009932195.1\|349794_351525_-\|DUF4365-domain-containing-protein	unknown	unknown	gnl\|CDD\|379535
NZ_MDMC01000008.1\|WP_010989474.1\|364674_365622_+\|MoxR-family-ATPase	unknown	unknown	gnl\|CDD\|223786
NZ_MDMC01000008.1\|WP_014601344.1\|352061_352226_-\|hypothetical-protein	unknown	unknown	unknown
NZ_MDMC01000008.1\|WP_010989479.1\|351763_352000_+\|hypothetical-protein	unknown	unknown	unknown
NZ_MDMC01000008.1\|WP_003721245.1\|360405_361506_-\|DUF917-domain-containing-protein	unknown	unknown	gnl\|CDD\|226065
NZ_MDMC01000008.1\|WP_069002837.1\|348200_349073_-\|hypothetical-protein	unknown	unknown	unknown
NZ_MDMC01000008.1\|WP_010989471.1\|369824_370490_+\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|226146
NZ_MDMC01000008.1\|WP_003733941.1\|352806_353112_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|273478
NZ_MDMC01000008.1\|WP_003721244.1\|361506_362790_-\|cytosine-permease	unknown	unknown	gnl\|CDD\|271377
NZ_MDMC01000008.1\|WP_009930718.1\|366771_368931_+\|transglutaminase	unknown	unknown	gnl\|CDD\|376628
NZ_MDMC01000008.1\|WP_010989476.1\|358862_360413_-\|hydantoinase/oxoprolinase-family-protein	unknown	unknown	gnl\|CDD\|223223
NZ_MDMC01000008.1\|WP_009931585.1\|353644_354118_-\|hypothetical-protein	unknown	unknown	unknown
NZ_MDMC01000008.1\|WP_014601342.1\|356504_358043_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|368260
NZ_MDMC01000008.1\|WP_009932193.1\|349426_349750_-\|AP2-domain-containing-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_MDMC01000008.1\|WP_009932195.1\|349794_351525_-\|DUF4365-domain-containing-protein	gnl\|CDD\|379535	pfam14280, DUF4365, Domain of unknown function (DUF4365). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 182 and 530 amino acids in length. There is a single completely conserved residue D that may be functionally important.	5.7395e-10
NZ_MDMC01000008.1\|WP_003721245.1\|360405_361506_-\|DUF917-domain-containing-protein	gnl\|CDD\|226065	COG3535, COG3535, Uncharacterized conserved protein [Function unknown].	0
NZ_MDMC01000008.1\|WP_009930717.1\|369048_369804_+\|DUF4866-domain-containing-protein	gnl\|CDD\|379782	pfam16160, DUF4866, Domain of unknown function (DUF4866). This family consists of uncharacterized proteins around 250 residues in length and is mainly found in various human gut Firmicute species and abundant in human gut metagenomic datasets. The function of this family is unknown.	3.03926e-122
NZ_MDMC01000008.1\|WP_010989475.1\|362923_364519_-\|PucR-family-transcriptional-regulator	gnl\|CDD\|225306	COG2508, COG2508, Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism].	1.08474e-59
NZ_MDMC01000008.1\|WP_010989473.1\|365626_366775_+\|DUF58-domain-containing-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	2.48336e-53
NZ_MDMC01000008.1\|WP_010989474.1\|364674_365622_+\|MoxR-family-ATPase	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.51988e-102
NZ_MDMC01000008.1\|WP_014601342.1\|356504_358043_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|368260	pfam05043, Mga, Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins. This is presumably a DNA-binding domain.	1.11775e-19
NZ_MDMC01000008.1\|WP_003733941.1\|352806_353112_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	4.04229e-05
NZ_MDMC01000008.1\|WP_010989476.1\|358862_360413_-\|hydantoinase/oxoprolinase-family-protein	gnl\|CDD\|223223	COG0145, HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.31898e-105
NZ_MDMC01000008.1\|WP_003721244.1\|361506_362790_-\|cytosine-permease	gnl\|CDD\|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	6.12636e-95
NZ_MDMC01000008.1\|WP_009930718.1\|366771_368931_+\|transglutaminase	gnl\|CDD\|376628	pfam01841, Transglut_core, Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.	5.52486e-28
NZ_MDMC01000008.1\|WP_010989471.1\|369824_370490_+\|DUF1275-domain-containing-protein	gnl\|CDD\|226146	COG3619, COG3619, Predicted membrane protein [Function unknown].	6.55182e-68

>NZ_MDMC01000008.1|WP_009931585.1|353644_354118_-|hypothetical-protein
MKKKKVVVISLLLLLVSVIGISSYFLFKDKINLLDVDPSAVEWNGKKQKDTSGEENTIAIPGFEKVTLYANETKQAVNFHNPEINDCYFKISLIHPDGSVLWRSDLIEPGKGMYSIELEKTLAVGEYENAVLKYECFSLNDQSPLNGSEINLKLVVV
>NZ_MDMC01000008.1|WP_009931584.1|353139_353625_-|hypothetical-protein
MNKLVLSTLSVAAMGMVIFSGGTAYAADKEGNTVVEYSVEGDYTLVVPEKVNLSNDNATEMSVKTINRNLEPGKEVEVTLSSGLSADGEIELERVGATSDVITSSFKSNNSTVTMANPVIGSFSGYAIEETEVSKIQIGSPQGDKKAGAYQTTLTFTAAFK
>NZ_MDMC01000008.1|WP_003733941.1|352806_353112_-|LPXTG-cell-wall-anchor-domain-containing-protein
MKRKLVLAMVLISFCGMFLLSPERVQASQTVVEVFISEDDLDVSEENIQEIPKKELAASSDKDNKQHMLPKAGDTVTNYTLLGLVLVLIWLIMQRKRKKKE
>NZ_MDMC01000008.1|WP_003721255.1|352464_352731_-|transposase
MARIEYGEEIQKSLLVLYSRGSTIDSICKEYGIPRYEFHKWMKLHDADKLETKEVKTLLQIRELKQQKNKLEEEILFLNEAINLLESP
>NZ_MDMC01000008.1|WP_014601344.1|352061_352226_-|hypothetical-protein
MYVESKEELEKIIYQQLINNINVKPDPWKWEERNALIVEIEVKAVLEKYGSTPI
>NZ_MDMC01000008.1|WP_010989479.1|351763_352000_+|hypothetical-protein
MSLKKILESDESIEKKEQQIDSYYQSELITRVEACELLDVSTKSLDRYIKQNKLSFQLNSLLIPHFCLIVLLMPLAIL
>NZ_MDMC01000008.1|WP_009932195.1|349794_351525_-|DUF4365-domain-containing-protein
MVKYTNPKIEKLGVNAVSNYIVESDYLSDFLAQQSTEPATDGTIRIYNGPGERKRDLIGIVPVQVKGTTTKNIIKYNRHEIDIVDLTYYYKVGGVVYFVVYVTNKVPKIYYRDLLRIDIKEILKKNEKLRGKKEKGTITIDFREVPVNVEDFRTVLLNFHKDQDYQTKDYVELGSINEISRDLTFTIIAPNSNIVEALKYVSPVLYKNEGDLKIPVRRFKIGELSVFTKSEFSIGIKGANSYIATVMEGEEETEIQIGSLQQLIVKFKEGRFKVDFEAKGKIQETIELLEILLGIVTGVNLYIDNKPVTEFFIEEVNEDFISRVNHALESFKKTQEALNHCKVPSNFHYEELTENDIDVINSIMELYQTSIDNTWGKFEFNNRLVYLLKHKGTIYNLLDSNVALEINFWSKREDGIQYTTTPLILIDDFSKMNDTEICNIKGPIEKLIPIHEKACSDINLICVRLIDAYDQTNNNQFLLVAFELLELIIPFTTNNEIHLIYLNKYQIKKRWDNLVMEDINHLVSIQKEFEEDKRIHLATLILLSAKNDAAQLLSELKNNEGFSLEDMPILNLLEKN
>NZ_MDMC01000008.1|WP_009932193.1|349426_349750_-|AP2-domain-containing-protein
MYQKASEKMKETMKANIALVESIRISSISNKKLQSDNKSGHTVVTFKDNKWVARICVSGVEHQLGSFVTKEEAIDARIEGEKYFQPLINKYNNRLDVFYSERRPFWT
>NZ_MDMC01000008.1|WP_010989480.1|349146_349452_-|hypothetical-protein
MNVDPFGRKVELMIIGNGLDVKANLASTFVDYYKHRCKLMRLEYNEDDFYRLKSKNYFPMKVKMQQFPSIRRCNIEILSIDAETAINENITFWDLVLFFCL
>NZ_MDMC01000008.1|WP_069002837.1|348200_349073_-|hypothetical-protein
MSDPINIILNNCGFGENLEDEQENDLYNLMEERLEEKDKYVLSVAFIHKLNSYSNCSLEEFLMLELNKYEKYFSDYIKTEVTNKYEEYHKTRNNILTKLSGGLGATHSISVMNFNFTPNQFSDSVKLNEKIGLAHVNVHGSYLANSIFGIDTKSLEDIDTIGSGYRFTKTYRKLTLKTKRSTEILYHDITDIIFYDHSLGQADYAYFQSIFDYLDIYNNTIVLTFYYSDYKENVREEQTIAVRNLIEEYGKTFDNKHKGKNLLHKLLLEERISVTDLEIYEEDYSSKDMK
>NZ_MDMC01000008.1|WP_014601342.1|356504_358043_-|helix-turn-helix-domain-containing-protein
MREYLDSKSQKKVALLEKIFYAENHTSTQEELLNDLNITYPTLISTIKTINFDIERFGYKAFSIVHSAPNLSYTLKISDNCSIQLIINAYIRESPKFQILETLLLASFPNLQALAKKVHVSYSGIKKEIKELNEELRERNLSISTGNQVEITGDEFSLRIFYAFLFLVTYSGDRWPFSFVQYDEITDLLESCPKEIYRANSIDKGMMIHYYVAMHLLRDRMNCQIDTTRQFKVALYKACTEESKKSESAFIKKVAKQLPNRNYKEITYTTQIILSTIVAFGSYSSIEKMPSFFYMDEQLEEMGFMKLVDFASERVNDNLSIPFSEKEMELLRYSFASINYRYFLLDNLINKFNNIVPGYTDLDRNIRKIHKVNHLEPLISQLVNLKEMRLLKPFEERLASDYLIILDKRIDFSIHTLPIKVTILSTISNETAVFDFMRYFSSYYNLEIINQVDPVVDLYISDFSVSPEVLTSLRINQPIVYVNTRWLESDYVKINDNLAKIARKKFIANKKD
>NZ_MDMC01000008.1|WP_010989476.1|358862_360413_-|hydantoinase/oxoprolinase-family-protein
MYKIGIDVGGTNTDAVILDENQQLIHSVKMPTSEDIETGITESLHRVLSETGIDRSKVTHAMLGTTQCTNAIVERKKLAKVGVLRLGYPATASVLPYTAWPEDMVGFLSGKYKLTGGGYEYDGQVLSEINEAEIRETLASWKGEVESVAVVGVFSSLKNDQELAVQKIIEEELGADIPVSISSSVGSVGLIERENATILNAALFKVIAATSDGFEKALEQEGIEHAEIYLCQNDGTLMSLNYARQFPILTIACGPTNSIRGASYLAGLKDAMVLDVGGTTSDIGVLTDGFPRESSLAVDVGGVRTNFRMPDIISIGLGGGSIVREKDGDITIGPDSVGYRISEEALVFGGKTMTTTDIAVRLGMAEIGNPELVAHIPTDFAEKAYKKIADMTEDAIDKMKTSSGSVSLVLVGGGSVIIPDEISGVAQIFRDKNGPVANAIGASISQISGQYEQIYIYSQIEREEALQDAEQKAREQATLAGAVTDSIEVVEVEEIPLAYHPGNATRLRVKVVGNLV
>NZ_MDMC01000008.1|WP_003721245.1|360405_361506_-|DUF917-domain-containing-protein
MRYLDEQAIENIAIGAAFLGTGGGGDPYIGKMMALTAIKKHGPIKLLSPEEIADDDYFIPAAMMGAPSVLIEKFPKGDEFVRVFEKLGRYVGKEVKGTFPMEAGGVNSMIPIVVAAQLGLPMVDCDGMGRAFPELQMVTFHLDGISATPMAITDEKGNIGIMETIDNKWTERLARVTTVEMGASSLVSLYPCNGAQIKQSSIKNIVTLSEEIGKVIRETSMDEAEKLQKLLDVTHGYHLFEGKITDVVRETRAGFNFGRVKIDGLNKDTNSEVIVHFQNENLVAEKNGEPIAITPDLICMVDLETLMPVTTEALKYGKRVRVMALPADDAWRTDKGIETVGPRYFGYDVDFEPLEELVKKEERRHV
>NZ_MDMC01000008.1|WP_003721244.1|361506_362790_-|cytosine-permease
MTEKKTVEQAQSWQSLAFVWTGAMICVPSLLVGGTLISGMPLWEAILIALLGYGVIVVFMIYQGMQSSDLGIPAVSVASQVFGEQGSKKIISILLAIACLGWFGIQANVCGAAFSQFLGIYGINLPVPVSSLIWGVIMLLSAIYGIRILSILNYIAVPILLFVCIYGLVVSLNNGGLAVVENYKPAGSMSFMTGLAITIGSFALGAVIAGDYSQYTKSRKDVVKAAIVGILPSGVLMIAVGAILALTAGTADISVVFTNLGLPVLGIIGLILAAWTTNAVNAFSGGIAIINVFNISEKYHKVAVAIAGGLGTVLAVIGILNHFVPIMSVLSAMVPPVAGVMIASYWIVQKGDKSKWAPVPGVNWLGVTSWLVGAVIAGIPVILTFFPALPQLPNQPLIGIILSLAVYLVGAKVLSGKTNNVENLEGK
>NZ_MDMC01000008.1|WP_010989475.1|362923_364519_-|PucR-family-transcriptional-regulator
MSVKLADLMKLPSLKEAKVVSGKSGLSKLVSSISVLEYTEVALLEDDLFDNDEFYGSEIVVSAFVNIRDDVEAQCRTIERLHKVGEVALILYYVGIFVPKMDQKLIDFANELDFTIIVMPENEMSLRYSEVIYEVVEAIVKQEMTDTNFVTESLEQISSVRPPQRNIDTTLKILSDRTHSSLVLTDNSFQVINSITWPRTRHWDFERVIETSKQIDEHELVQLHLDERDFYTARKPIFQDGMQAMHLFMMKEKGALTADVVMQITEVVQVFMNLWGRNYVEISTAELMKAILNDESVKMRRLGKILNVDVSSIKWMWLVKTEEIRNNEQVLAELKSFVASHFQVSLIDLFEDNIVVLLDNSVGQRDRTHTANEFAMMMKEHGIDLKITVCQGMEQTSDVQSAYSLVNEYKNAANAIYANKSIYSLQEIDFAAKCVEIVDRGELAIAEQMRPLKSLEDNDELIETLSVFLLEGESNYNQAAELLFLHKNTIKYRIQRINELLQYPATKIPESYNLYLAVAIRRLLGGNNNNK
>NZ_MDMC01000008.1|WP_010989474.1|364674_365622_+|MoxR-family-ATPase
MSIEPSIKINEIINEVEKVIVGKRHVVKLSLTALLAGGHVLLEDVPGVGKTMMVRTLSKTIGVSFKRIQFTPDLLPADVTGVSIFNPETRDFEFRPGPVMGNIVLADEINRTAPRTQAALLEGMAENSVTVDGITRKLANPFFVMATQNPIEYEGTYALPEAQLDRFLLKINIGYPTVEEEMQLLTLKQYQDPLDQTKQVVTLSELLDLKNKAKQVFIDDVLKNYIIRLVDATRKHPSVALGISPRGSLAFMQAAQAFALIEGRDYVIPDDIQYLAPYIFTHRLILKSEAYYNEETAESIIASILKNTSVPVEKR
>NZ_MDMC01000008.1|WP_010989473.1|365626_366775_+|DUF58-domain-containing-protein
MLKKRLLLASRWIIMLIIYAGLWTYTLFQGDTASWFLTYFFSFILLLLFLSSIYPLKAWKVNRSFVKNTYHDGDLIDMQVSFTRKSRYPVGYLLFQQKIPATFGKVRARQQVVYPLFKKQFTVTLAGFVGVRGIHSFPPVDVETSDAFGLLERSRQLSSEKSLTIYPTYFPNVLEKISEASPENERNAAYWTLKKNSNLHSLREFSSGDRISLIDWKSSAKSDQLMTREFENSATSRLSVIFYGASHPNFELSLRAAYSFIRKISEENGEIRVTLLGDQTSKFAPAKGTSRLQDISTAFAEIAPVDSLTLQESLDSNLHSGEKILLFTPCMDTMLMQKVTRLTDNKQLQIITFQSEHSKAMDAPAIFLEQASLLSRWERETK
>NZ_MDMC01000008.1|WP_009930718.1|366771_368931_+|transglutaminase
MKRYLTLVMLFILSVLLISEWIYPFAELTELSTATWIILFITLSLGSFFLRLKYYWTIPLHVVMIIIVSGIYYAKGGILAGNWLGSFFQITFNGFRDMVQFRSSDISMDFILIVFLIALWLLSYITTYSILRKQRIMSVLVLTVAYLAVINTFTDYNSNWAIVRTVLEGFLLLHLALASRIATPNRISADSLKRNGLFYHGFVILLLAVFVFSSLMLPKKAPIFPDPIPTIKNALGINTTRTVGYSEDDTTLGGALKKDNATVFTAQAEKGHYWRVESKTVYTGTGWANANSGDVISFSSGDNFPIQLTEQTTGATNTAEISFASSSDYMPYPYGTQAVNGAVDSFSANLTIERVGPVDTIKNYTVQLKTPVYNIEKMQNADFSTLSNAFVSQYTQTPKDLPDRVTKLANKVTKDADSIYDKTKAIESYLSTSGTFTYSTDDAKETPMGADYVDQFLFETQIGYCDNFSTSMVVMLRSLGIPARWAKGYTPGEGEKKENDAKTTYTITNNNAHSWPEVFFPGTGWVPFEPTATFSNPENFQEPTTETANKPETPNDSTSTPETPNTPDKTPEQDNGSSSTGETPKKEEPKTETATSNVEIPSWVWWIPAGLVVALLALAIVFRRRIRGYLLLRSLRNSPEFGKTYHRLMKLLASYGYVRESSETLRHFSARVDADLTTSEFSRLTKMYETQLYSKNLTEKVIAAEETQLVQQIIARLTK
>NZ_MDMC01000008.1|WP_009930717.1|369048_369804_+|DUF4866-domain-containing-protein
MTTIFPKEQNVTPLFEQILANPTACRRFKDVFLDNLESYQETRGFEKDDTLFAKIILSAYRQSDVSALLLGVCGRTLFELLRQAFLIPKKLTVDNPFFLTDKEGNFIAKKDDISNREQEKFQEIYQSDLHHSETTIFLVDDDDIVHSYEPDFSISTKRINKKRGILVLYSLPDTLKSGMTESEVYAFIWKTFLHIQEIIPSSRIFYGQETSENADELGVFLPIHHFEKKMLQNIEQVNELVDALREQMVNK
>NZ_MDMC01000008.1|WP_010989471.1|369824_370490_+|DUF1275-domain-containing-protein
MARTRQISESIGLGLLLALAGGFMDAYSYIERGQVFANAQTGNILLFGINISEGNWAIAIQYFWPVVSFTVGIALSEVIHRRDIRRLHWRQLSVLIEAVILIGVAFIPLDHNLIANSLISFVCGIQVESFRKMHGRGVATTMCIGNLRSATQNLCDYFEYKEKQYLHNSFLYFSVILSFIIGAVVGNFFIQLFAQYAILVCAFLQLIAFMMMFIDRESKII

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_MDMC01000008_1	1.2\|309854\|35\|NZ_MDMC01000008\|PILER-CR,CRISPRCasFinder,CRT	309854-309888	35	MH341453	Listeria phage PSU-VKH-LP041, complete genome	10139-10173	1	0.971
NZ_MDMC01000008_1	1.2\|309854\|35\|NZ_MDMC01000008\|PILER-CR,CRISPRCasFinder,CRT	309854-309888	35	NC_009813	Listeria phage B054, complete genome	10139-10173	2	0.943

1. spacer 1.2|309854|35|NZ_MDMC01000008|PILER-CR,CRISPRCasFinder,CRT matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 1, identity: 0.971

ttgtaacccatcgctgtccctttgacaaaaatcgc	CRISPR spacer
ttgtaacccatcgctgttcctttgacaaaaatcgc	Protospacer
*****************.*****************

2. spacer 1.2|309854|35|NZ_MDMC01000008|PILER-CR,CRISPRCasFinder,CRT matches to NC_009813 (Listeria phage B054, complete genome) position: , mismatch: 2, identity: 0.943

ttgtaacccatcgctgtccctttgacaaaaatcgc	CRISPR spacer
ttgtaacccatcgccgttcctttgacaaaaatcgc	Protospacer
**************.**.*****************

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

7. NZ_MDMC01000004

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

90099 : 98385

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003722243.1\|90099_90666_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.0e-25	35.9
WP_009933235.1\|90662_91712_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.0e-61	43.2
WP_010989807.1\|91730_93158_-	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	8.1e-54	31.9
WP_010989808.1\|93142_95362_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.0e-160	41.2
WP_003733240.1\|95354_96038_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_003722248.1\|96041_96287_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_010989809.1\|96298_97012_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	2.3e-41	38.3
WP_003733238.1\|97092_98385_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	7.2e-17	32.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

8. NZ_MDMC01000007

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

490415 : 517219

Listeria_phage(94.12%)

tail,terminase,holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003733517.1\|490415_490847_+	hypothetical protein	A8ATJ2	Listeria_phage	4.1e-25	81.7
WP_069002816.1\|490843_491344_+	hypothetical protein	A8ATW6	Listeria_phage	9.4e-66	71.8
WP_012951560.1\|491549_492548_-	DUF3644 domain-containing protein	A0A0N9RUA4	Staphylococcus_phage	3.9e-71	44.8
WP_014930186.1\|492650_493496_-	M15 family metallopeptidase	A0A059T7Y8	Listeria_phage	7.2e-135	86.9
WP_003733521.1\|493495_493762_-\|holin	phage holin	A0A059T684	Listeria_phage	9.8e-38	93.1
WP_014930187.1\|493761_494064_-	hypothetical protein	A0A059T5E6	Listeria_phage	2.2e-38	92.0
WP_014601493.1\|494114_496280_-\|tail	phage tail protein	A8ATW1	Listeria_phage	0.0e+00	94.5
WP_014930188.1\|496292_497861_-\|tail	phage tail family protein	A8ATW0	Listeria_phage	2.0e-303	99.0
WP_069002818.1\|497857_502657_-\|tail	phage tail tape measure protein	A8ATV9	Listeria_phage	0.0e+00	89.8
WP_072218650.1\|502661_502973_-	hypothetical protein	A0A0B5D116	Listeria_phage	1.2e-42	98.9
WP_003733698.1\|502969_503401_-	hypothetical protein	A8ATV7	Listeria_phage	4.0e-73	97.9
WP_003733697.1\|503456_504146_-	Ig domain-containing protein	A8ATV6	Listeria_phage	2.8e-100	85.6
WP_003725064.1\|504150_504522_-	hypothetical protein	A8ATV5	Listeria_phage	8.5e-64	100.0
WP_003733696.1\|504518_504836_-	HK97 gp10 family phage protein	A8ATV4	Listeria_phage	4.6e-50	96.2
WP_003733695.1\|504825_505191_-	hypothetical protein	A8ATV3	Listeria_phage	9.9e-65	99.2
WP_003723785.1\|505190_505544_-	hypothetical protein	A8ATV2	Listeria_phage	8.4e-61	99.1
WP_003725067.1\|505544_505700_-	hypothetical protein	A0A0B5CYK6	Listeria_phage	1.0e-18	98.0
WP_003725068.1\|505713_506586_-	hypothetical protein	A0A0B5CTX8	Listeria_phage	4.5e-164	99.7
WP_003744996.1\|506608_507163_-	hypothetical protein	A8ATU9	Listeria_phage	1.1e-88	99.5
WP_023552448.1\|507258_508302_-	hypothetical protein	A0A0B5D111	Listeria_phage	5.3e-196	97.7
WP_023552450.1\|508306_509866_-	hypothetical protein	A0A0B5D0A6	Listeria_phage	3.1e-293	97.3
WP_045131573.1\|509880_511227_-\|terminase	PBSX family phage terminase large subunit	A0A0B5CYJ6	Listeria_phage	1.5e-251	93.6
WP_003733717.1\|511192_511918_-	helix-turn-helix domain-containing protein	A0A0B5CTX0	Listeria_phage	4.4e-80	68.5
WP_003733718.1\|511961_512189_-	hypothetical protein	A0A0B5CTV3	Listeria_phage	2.4e-32	94.7
WP_025370640.1\|512464_512899_-	hypothetical protein	A8ASQ1	Listeria_phage	3.1e-57	76.4
WP_003733720.1\|512963_513461_-	Holliday junction resolvase RecU	A0A1L2JY30	Aeribacillus_phage	1.8e-32	49.3
WP_069002820.1\|513450_513633_-	hypothetical protein	A8ASP6	Listeria_phage	4.2e-16	77.8
WP_014601507.1\|513651_514134_-	single-stranded DNA-binding protein	A0A059T5E0	Listeria_phage	1.1e-52	66.9
WP_014601508.1\|514202_514361_-	hypothetical protein	NA	NA	NA	NA
WP_014601509.1\|514361_514571_-	hypothetical protein	A8ATE0	Listeria_phage	1.7e-32	100.0
WP_014601510.1\|514567_514969_-	hypothetical protein	A8ATD9	Listeria_phage	2.6e-74	100.0
WP_014601511.1\|515027_515588_-	DUF1642 domain-containing protein	A8ATY9	Listeria_phage	9.4e-107	100.0
WP_077951400.1\|515584_516049_-	class I SAM-dependent methyltransferase	A0A059T693	Listeria_phage	9.0e-87	96.8
WP_003731837.1\|516113_516722_-	hypothetical protein	A8ATU1	Listeria_phage	1.4e-55	49.5
WP_069002823.1\|516849_517219_-	pentapeptide repeat-containing protein	A8ATE4	Listeria_phage	1.1e-34	93.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

9. NZ_MDMC01000009

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

268541 : 275964

Hokovirus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003721506.1\|268541_268925_+	glycerol-3-phosphate cytidylyltransferase	A0A1V0SGE7	Hokovirus	1.4e-16	40.7
WP_010989659.1\|268946_269930_+	glycosyltransferase family 2 protein	A0A1V0SAH6	Catovirus	4.1e-12	34.6
WP_010989660.1\|269944_270958_+	glycosyltransferase	A0A1V0SAH6	Catovirus	7.9e-11	32.0
WP_003721509.1\|271166_272657_+	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	9.5e-114	49.7
WP_009931487.1\|272668_273493_+	ammonia-dependent NAD(+) synthetase	G3MA24	Bacillus_virus	7.4e-68	52.6
WP_009931485.1\|273505_273814_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
WP_009931483.1\|273874_274279_+	PTS sugar transporter subunit IIB	NA	NA	NA	NA
WP_010989661.1\|274407_275964_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	2.3e-17	28.1

DBSCAN-SWA_2

408724 : 468215

Bacillus_virus(15.79%)

protease,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_003723562.1\|408724_409864_-\|protease	PrsW family intramembrane metalloprotease	NA	NA	NA	NA
WP_003723563.1\|409944_410340_-	helix-turn-helix transcriptional regulator	A9D9J6	Lactobacillus_prophage	1.3e-14	57.4
WP_003727524.1\|410490_410706_+	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_010989719.1\|410824_411358_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA
WP_003732795.1\|411375_412041_+	hypothetical protein	NA	NA	NA	NA
WP_003732796.1\|412302_413241_+	hypothetical protein	NA	NA	NA	NA
WP_003723884.1\|413355_414639_+	trigger factor	NA	NA	NA	NA
WP_003723886.1\|414824_416084_+\|protease	ATP-dependent protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	1.4e-145	63.2
WP_003723887.1\|416202_416769_+	type I signal peptidase SipX	NA	NA	NA	NA
WP_003723888.1\|416803_417373_+	type I signal peptidase SipY	NA	NA	NA	NA
WP_003723889.1\|417474_418017_+	type I signal peptidase SipZ	NA	NA	NA	NA
WP_003723890.1\|418026_418890_+	ribosome biogenesis GTPase YlqF	NA	NA	NA	NA
WP_003723891.1\|418886_419672_+	ribonuclease HII	G4YAY0	Emiliania_huxleyi_virus	3.0e-26	39.2
WP_010989720.1\|419805_420666_+	DNA-protecting protein DprA	S6BFL3	Thermus_phage	6.9e-40	43.2
WP_009924617.1\|420937_423016_+	type I DNA topoisomerase	A0A1V0SB35	Catovirus	1.4e-107	37.7
WP_010989721.1\|423078_424383_+\|tRNA	FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))- methyltransferase TrmFO	NA	NA	NA	NA
WP_009911635.1\|424665_425568_+	tyrosine recombinase XerC	A0A1B1IQT7	uncultured_Mediterranean_phage	8.0e-23	28.0
WP_014601431.1\|425588_426128_+\|protease	ATP-dependent protease subunit HslV	NA	NA	NA	NA
WP_010989722.1\|426141_427551_+\|protease	ATP-dependent protease ATPase subunit HslU	A0A1B2IBU3	Erwinia_phage	5.2e-29	25.9
WP_003726695.1\|427571_428351_+	GTP-sensing pleiotropic transcriptional regulator CodY	NA	NA	NA	NA
WP_012951573.1\|428453_428873_+	acyl-CoA thioesterase	NA	NA	NA	NA
WP_003724130.1\|428895_429207_+	hypothetical protein	NA	NA	NA	NA
WP_009932949.1\|429209_430082_+	aldose 1-epimerase family protein	NA	NA	NA	NA
WP_003724132.1\|430123_430720_-	glycerol-3-phosphate 1-O-acyltransferase PlsY	NA	NA	NA	NA
WP_003732802.1\|430877_431285_+	CoA-binding protein	NA	NA	NA	NA
WP_003723731.1\|431465_433433_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	6.7e-123	42.5
WP_010989723.1\|433429_435889_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	4.7e-102	31.6
WP_003723733.1\|435971_436439_+	S-ribosylhomocysteine lyase	NA	NA	NA	NA
WP_010989724.1\|436768_438550_+	lmo1289 family class 1 internalin	NA	NA	NA	NA
WP_010989725.1\|438881_440678_+	class 1 internalin InlK	NA	NA	NA	NA
WP_009932001.1\|440710_442579_-	peptidoglycan O-acetyltransferase OatA	B5WZU0	Pseudomonas_phage	1.1e-42	31.9
WP_003723737.1\|442791_443490_+	glycerophosphodiester phosphodiesterase	A0A0S2MYI4	Enterococcus_phage	1.3e-12	32.4
WP_003723738.1\|443722_445399_+	glycerol-3-phosphate dehydrogenase/oxidase	NA	NA	NA	NA
WP_010989726.1\|445524_446442_+\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
WP_003719566.1\|446564_446798_+	RNA chaperone Hfq	NA	NA	NA	NA
WP_010989727.1\|446908_448132_+	GTPase HflX	NA	NA	NA	NA
WP_010989728.1\|448124_449351_+	methionine gamma-lyase family protein	NA	NA	NA	NA
WP_003719570.1\|449554_449923_+	MerR family transcriptional regulator	NA	NA	NA	NA
WP_003723435.1\|449993_451328_+	type I glutamate--ammonia ligase	M1NM71	Moumouvirus	4.2e-12	23.8
WP_003723436.1\|451471_452767_+	arsenical efflux pump membrane protein ArsB	A0A2H4PQU3	Staphylococcus_phage	1.8e-145	61.6
WP_010989729.1\|452810_453332_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_009930693.1\|453361_453976_-	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	9.3e-15	62.1
WP_003723439.1\|454132_454462_+	cell division suppressor protein YneA	NA	NA	NA	NA
WP_003723440.1\|454553_454781_+	DUF896 domain-containing protein	NA	NA	NA	NA
WP_010989730.1\|454927_456922_+	transketolase	NA	NA	NA	NA
WP_003723442.1\|457142_457382_+	YneF family protein	NA	NA	NA	NA
WP_010989731.1\|457432_458275_-	DUF2785 domain-containing protein	NA	NA	NA	NA
WP_009930695.1\|458293_459025_-	methyltransferase domain-containing protein	A0A1X9I6N4	Streptococcus_phage	3.4e-80	58.7
WP_003723445.1\|459046_459553_-	ParB-like nuclease domain-containing protein	A0A220GKT8	Streptococcus_phage	4.0e-56	66.7
WP_003723446.1\|459562_460867_-	DUF3440 domain-containing protein	A0A220GKF8	Streptococcus_phage	9.5e-134	52.1
WP_010989732.1\|460856_462062_-	helicase SNF2	L0P6E9	Lactobacillus_phage	4.9e-92	47.1
WP_003723448.1\|462039_462414_-	hypothetical protein	NA	NA	NA	NA
WP_003723449.1\|462706_463435_+	UMP kinase	NA	NA	NA	NA
WP_003723450.1\|463434_463992_+	ribosome recycling factor	NA	NA	NA	NA
WP_003732812.1\|464221_464980_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	4.4e-22	42.1
WP_003732813.1\|464993_465782_+	phosphatidate cytidylyltransferase	NA	NA	NA	NA
WP_010989733.1\|465796_466939_+	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
WP_003723454.1\|466952_468215_+\|protease	RIP metalloprotease RseP	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage