CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NZ_CP022712	Enterococcus faecalis strain KB1 chromosome	3 crisprs	cas3,DinG,DEDDh,csa3,RT,WYL,cas14j	1	3	8	4

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: NZ_CP022712_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022712_1

794984-795283

Orphan

II-A,II-B:NA

Consensus_repeat	Method
GTTTTGGTACCATTCCAAACAACATGACTCTAAAAC	CRISPRCasFinder
AAACAACATGACTCTAAAAC	CRT
GTTTTGGTACCATTCCAAACAACATGACTCTAAAAC	PILER-CR

4 spacers

The CRISPR arrays of NZ_CP022712_1

>merge|NZ_CP022712|1|794984-795283|CRISPRCasFinder,CRT,PILER-CR
GTGATAGTTTGTTTTTTAACAACATGACTCTAAAACGATTCCGAGTGATTCACTTTTAGCTTGTTCGTTTTGGTACCATTCTAAACAACATGACTCTAAAACAACGTTTTTAGGGATCCAAATACCTTTAAAGTTTTGGTACCATTCCAAACAACATGACTCTAAAACAGAGACAGCGGGAAAACTACGATATTCATCGTTTTGGTACCATTCCAAACAACATGACTCTAAAACCAATGTGTCTGCATTGATATGCTGAGAAATGTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

>NZ_CP022712|1|1|794984-795283|CRISPRCasFinder
GTGATAGTTTGTTTTTTAACAACATGACTCTAAAAC	GATTCCGAGTGATTCACTTTTAGCTTGTTC
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	AACGTTTTTAGGGATCCAAATACCTTTAAA
GTTTTGGTACCATTCCAAACAACATGACTCTAAAAC	AGAGACAGCGGGAAAACTACGATATTCATC
GTTTTGGTACCATTCCAAACAACATGACTCTAAAAC	CAATGTGTCTGCATTGATATGCTGAGAAAT
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

>NZ_CP022712|1|1|795000-795283|CRT
TAACAACATGACTCTAAAAC	GATTCCGAGTGATTCACTTTTAGCTTGTTCGTTTTGGTACCATTCT
AAACAACATGACTCTAAAAC	AACGTTTTTAGGGATCCAAATACCTTTAAAGTTTTGGTACCATTCC
AAACAACATGACTCTAAAAC	AGAGACAGCGGGAAAACTACGATATTCATCGTTTTGGTACCATTCC
AAACAACATGACTCTAAAAC	CAATGTGTCTGCATTGATATGCTGAGAAATGTTTTGGTACCATTCT
AAACAACATGACTCTAAAAC

>NZ_CP022712|1|1|795050-795283|PILER-CR
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC	AACGTTTTTAGGGATCCAAATACCTTTAAA
GTTTTGGTACCATTCCAAACAACATGACTCTAAAAC	AGAGACAGCGGGAAAACTACGATATTCATC
GTTTTGGTACCATTCCAAACAACATGACTCTAAAAC	CAATGTGTCTGCATTGATATGCTGAGAAAT
GTTTTGGTACCATTCTAAACAACATGACTCTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022712.1\|WP_002364244.1\|781751_782453_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
NZ_CP022712.1\|WP_002360011.1\|800297_801536_+\|multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|340949
NZ_CP022712.1\|WP_002360016.1\|786560_787466_-\|prenyltransferase	unknown	unknown	gnl\|CDD\|235695
NZ_CP022712.1\|WP_002381711.1\|780884_781634_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
NZ_CP022712.1\|WP_002380448.1\|782583_785007_-\|DNA-translocase-FtsK	unknown	unknown	gnl\|CDD\|224588
NZ_CP022712.1\|WP_002379584.1\|799063_799633_-\|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379115
NZ_CP022712.1\|WP_002380452.1\|796388_798470_-\|DNA-topoisomerase-III	unknown	unknown	gnl\|CDD\|236078
NZ_CP022712.1\|WP_002381710.1\|788647_790414_-\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|227320
NZ_CP022712.1\|WP_002356959.1\|803065_803410_-\|DUF1831-domain-containing-protein	unknown	unknown	gnl\|CDD\|370163
NZ_CP022712.1\|WP_002380449.1\|785320_786532_-\|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224172
NZ_CP022712.1\|WP_002362076.1\|804779_805754_-\|ribose-phosphate-diphosphokinase	unknown	unknown	gnl\|CDD\|235039
NZ_CP022712.1\|WP_002360015.1\|787587_788568_+\|polyprenyl-synthetase-family-protein	unknown	unknown	gnl\|CDD\|223220
NZ_CP022712.1\|WP_065536071.1\|801715_802840_-\|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl\|CDD\|234664
NZ_CP022712.1\|WP_002356963.1\|799765_800281_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	unknown	unknown	gnl\|CDD\|176643
NZ_CP022712.1\|WP_002356966.1\|798600_798966_-\|DUF1033-family-protein	unknown	unknown	gnl\|CDD\|336361
NZ_CP022712.1\|WP_065536070.1\|790410_792144_-\|thiol-reductant-ABC-exporter-subunit-CydD	unknown	unknown	gnl\|CDD\|274323
NZ_CP022712.1\|WP_002380451.1\|795440_796304_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
NZ_CP022712.1\|WP_002356974.1\|793158_794577_-\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
NZ_CP022712.1\|WP_002378485.1\|803477_804623_-\|cysteine-desulfurase	unknown	unknown	gnl\|CDD\|224029
NZ_CP022712.1\|WP_002356976.1\|792148_793162_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|376764

Protein	Function_ID	Function_description	E-value
NZ_CP022712.1\|WP_002364244.1\|781751_782453_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.52313e-37
NZ_CP022712.1\|WP_002360011.1\|800297_801536_+\|multidrug-efflux-MFS-transporter	gnl\|CDD\|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.24866e-173
NZ_CP022712.1\|WP_002360016.1\|786560_787466_-\|prenyltransferase	gnl\|CDD\|235695	PRK06080, PRK06080, 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated.	8.82053e-105
NZ_CP022712.1\|WP_002381711.1\|780884_781634_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	2.63593e-110
NZ_CP022712.1\|WP_002380448.1\|782583_785007_-\|DNA-translocase-FtsK	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	2.52612e-175
NZ_CP022712.1\|WP_002379584.1\|799063_799633_-\|TetR/AcrR-family-transcriptional-regulator	gnl\|CDD\|379115	pfam13305, WHG, WHG domain. This presumed domain is around 80 amino acids in length. It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. The domain is named WHG after three conserved residues near the C-terminus of the domain.	1.88451e-15
NZ_CP022712.1\|WP_002380452.1\|796388_798470_-\|DNA-topoisomerase-III	gnl\|CDD\|236078	PRK07726, PRK07726, DNA topoisomerase 3.	0
NZ_CP022712.1\|WP_002381710.1\|788647_790414_-\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|227320	COG4987, CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
NZ_CP022712.1\|WP_002356959.1\|803065_803410_-\|DUF1831-domain-containing-protein	gnl\|CDD\|370163	pfam08866, DUF1831, Putative amino acid metabolism. Solution of the structure of the Lactobacillus plantarum protein from this family has indicated a potential new fold with remote similarities to TBP-like (TATA-binding protein) structures. This similarity, in combination with genomic context analysis, leads us to propose an involvement in amino-acid metabolism. The potentially novel fold is an alpha + beta fold comprising two beta sheets packed against a single helix. The enzyme is present in the cytosol.	1.33245e-53
NZ_CP022712.1\|WP_002380449.1\|785320_786532_-\|NAD(P)/FAD-dependent-oxidoreductase	gnl\|CDD\|224172	COG1252, Ndh, NADH dehydrogenase, FAD-containing subunit [Energy production and conversion].	5.21914e-122
NZ_CP022712.1\|WP_002362076.1\|804779_805754_-\|ribose-phosphate-diphosphokinase	gnl\|CDD\|235039	PRK02458, PRK02458, ribose-phosphate pyrophosphokinase; Provisional.	0
NZ_CP022712.1\|WP_002360015.1\|787587_788568_+\|polyprenyl-synthetase-family-protein	gnl\|CDD\|223220	COG0142, IspA, Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism].	2.52576e-80
NZ_CP022712.1\|WP_065536071.1\|801715_802840_-\|tRNA-2-thiouridine(34)-synthase-MnmA	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
NZ_CP022712.1\|WP_002356963.1\|799765_800281_+\|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein	gnl\|CDD\|176643	cd00865, PEBP_bact_arch, PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea. PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.	5.73504e-32
NZ_CP022712.1\|WP_002356966.1\|798600_798966_-\|DUF1033-family-protein	gnl\|CDD\|336361	pfam06279, DUF1033, Protein of unknown function (DUF1033). This family consists of several hypothetical bacterial proteins. Many of the sequences in this family are annotated as putative DNA binding proteins but the function of this family is unknown.	4.62165e-64
NZ_CP022712.1\|WP_065536070.1\|790410_792144_-\|thiol-reductant-ABC-exporter-subunit-CydD	gnl\|CDD\|274323	TIGR02857, transport_ATP-binding_protein, thiol reductant ABC exporter, CydD subunit. The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD.	0
NZ_CP022712.1\|WP_002380451.1\|795440_796304_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.22379e-26
NZ_CP022712.1\|WP_002356974.1\|793158_794577_-\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
NZ_CP022712.1\|WP_002378485.1\|803477_804623_-\|cysteine-desulfurase	gnl\|CDD\|224029	COG1104, NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism].	1.04062e-178
NZ_CP022712.1\|WP_002356976.1\|792148_793162_-\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|376764	pfam02322, Cyt_bd_oxida_II, Cytochrome bd terminal oxidase subunit II. This family consists of cytochrome bd type terminal oxidases that catalyze quinol-dependent, Na+-independent oxygen uptake. Members of this family are integral membrane proteins and contain a protohaem IX centre B558. One member of the family, Klebsiella pneumoniae CydB, is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella pneumoniae. The family forms an integral functional unit with subunit I, family Bac_Ubq_Cox, pfam01654.	9.60464e-103

>NZ_CP022712.1|WP_002356974.1|793158_794577_-|cytochrome-ubiquinol-oxidase-subunit-I
MFDIVTLARIQFAMTTVFHFFFVPFSIGLALVVAIMETMYVVKKEERYRKMAKFWGNIFLLSFAVGVVTGIIQEFQFGMNWSDYSRFVGDIFGAPLAVEALLAFFLESTFLGLWIFTWDKMNPKVHVTFIWLVVFGSMMSAFWILVANSFMQHPVGYVINNGRAEMVDFVAVISNPKVWYEFSHVIMGAFTLGGMAVAGMAAFQLLKKRDISFHKASMRIGLWVTLFGSIGVLLAGDLQMKALIEGQPMKFAAMEGAYEDSDDPAAWTLIAWADEREHKQVFGIDIPYMLSILSYNKLSGSVDGMDTVNKRLVEKYGDDKNYYPPVNTLFWSFRIMAGFGALMLLVAALGLFFTRKKKPSLYEKKWMLWIVALCTFAPFLANTTGWLVTELGRYPWTVYGLFTIEQSVSPNVSVASLITSNVIYFLLFAGLGSVMVYLVILELRKGPDYEAKKLAKENEPALDPFDKGVFGE
>NZ_CP022712.1|WP_002356976.1|792148_793162_-|cytochrome-d-ubiquinol-oxidase-subunit-II
MSTLQLLWFVLIGVLFSGFFFLEGFDFGVGMAVQTLAHNDDEKDQVVATIGPVWDGNEVWLLTAGGAMFASFPYWYASLFSGYYLILFTILFGLIIRGVSFEFRHNMPEGKRRRMWNWTLSIGSFLVPFFFGILFISLVQGMPLDANGNMHAQFTDYFNLFSIVGGVALTLLCYLHGMNYIALKTEGPIRERARNYAEILYGVLYVGLVVFAVLMYFKTDFYEKNFAVTLILTLAIVVLTVIANVGVFKRKEMLAFLASGLTLVVLVALLFSGLFPRVMIGSEGFDLLIKDATSTPYTLKIMTWISLSILPFVLAYTAWSYYIFRKRISQTAVPEGY
>NZ_CP022712.1|WP_065536070.1|790410_792144_-|thiol-reductant-ABC-exporter-subunit-CydD
MIDKDILQMPKIKKILVLLAGFSFLQAVFIIGQAFFLSKAIVGLWSGGHLNQQLQSILLFFIFYLGRHVITYFRERMLDTFSYERSKELREQLLTKIFRLGSNVVQKNGTGNMVTMALEGISQTENYLQLILTKMMNMMIIPWIILAFVFTQDIRSGITLLIVFPIIIIFMIVLGYAAQSKADKQYAAFQMLSNHFIDSLRGIDTLKLFGLSKKYAGSIYHTSERFRKATMSTLKIAILSTFALDFFTTLSVAVVAVFLGLSLLNGTILLFPALVTLILAPEFFLPIRDFSSDYHATLDGKNSFQAIQAVLALPEAEQTDVLTLDDWHQESQLSVTALNFSYEDATQEAIQSLQFSVDGRKKIGIIGASGSGKSTLINLLSGFLLPTEETSQLAINGQTIPHFLQKDWQKQILYIPQAPYIFQDTLANNIRFYTPEATDEAIQQAIQLVGLDELVKDLPEGIHTLIRESGRMLSGGQAQRVALARAFVDQKRHVLLFDEPTAHLDIETEVEMKERMLPLMNNHLVFFATHRLHWMEEMDYILVMEKGQLVEQGTLAELIEKDGYYVQLMKQMRGGRQ
>NZ_CP022712.1|WP_002381710.1|788647_790414_-|thiol-reductant-ABC-exporter-subunit-CydC
MMEKQPTTKDVWKNDQWVRPFLKRYKKTLYFALLLGFLTFFSAGALMFTSGYLISRAASLPENILLIYIPIVLTRAFGIGRPVFRYVERLTSHNWVLKMTSDLRLKLYNVLEKDAIFFKTKYRTGDILGLLSEDINHIQNLYLRTIFPTVIAWILYIFLVIALGFFSWWFALCMLLMLGVVVFLLPLVSVLVNGARQEKHKYAKNELYQTLTDNILGVSDWVFSQRGSEFVARYETDEANVRALDEKMKQFNRGRDFVLQLLFGVIAIAVLAWTSVRFPGNHGGAANWIGAFVLTVFPLIDAFAPLPAAAQETTIYKDSIRRFNELPEGEDDSTEAPVQPNGTSLSIEHLSFAYENQEKKVLNDLSLTIPEQQKLAILGRSGSGKSTLASLIRGDLRPTSGEILLGNIPTEAFGETMTEYIGVMHQAPYLFRTTILNNIRIGREEASEAEVWAVLEKVGLKEMVTQLPEGLQTMVDEAGLRFSGGERHRLALARILLQDTPIVLLDEPTTGLDPITEQQLLETFFEALKDKTVIWITHHLQGVTLMDQVIFIEDGQLEMSGTPEELLATNAHYQKLYRIDRGISSFEE
>NZ_CP022712.1|WP_002360015.1|787587_788568_+|polyprenyl-synthetase-family-protein
MNTFWKSFPDVERSLTETCELIEQTLHTRNEDIEEALVTLARSGGKLLRPAFFFLFAQLGDEEKQEKQQLLKIAASLEILHMATLIHDDIIDDSPLRRGAVTIQSQYGKDVAVYTGDLLFTEFFTLIADAMNGSEFMKINAQGMKRLLLGELDQMSHRFDRRMSIPAYLRSVNGKTAELFSLSCLEGAYFGHSSKEVQRLAKRIGRHIGIAFQVYDDILDYTADTETLKKPALEDLSQGVYTLPLLFAYQAAPDVFSPYLDKGRAITLEEAAEVAALVNDYHGVTEAQAFAKKVTNKAITDIQQLPDGTAKETLLSLTELLLHRSF
>NZ_CP022712.1|WP_002360016.1|786560_787466_-|prenyltransferase
MNREIFFELVELKAKTASVLPFLLGICFSWYQYGRLHVGYVLIFFIAMFIFNMAVDILDNYNDYHHATEVHDYKEKTNIIGRENLSLPLIRKMIFWMILVSALMGIGLSFIVGWPLLIMGLYCYLIGIFYSSGPKPLSSLPLGEVFSGFTMGFMITLICVYINTFEVFNWSAANLWGIFLVALPNTCYIANLMLANNICDLEEDENNKRYTLVHYLGKASSLKLFVGLNTIAMLAILLAVGLGLTPPTMLLMLLTLPFVRKQTQALLKEQVKSKTFVCAVKILAVGATAQVLFFAIGLWWL
>NZ_CP022712.1|WP_002380449.1|785320_786532_-|NAD(P)/FAD-dependent-oxidoreductase
MNKKHVVILGAGYAGLKTLRELQKGAKDVEITLVDRNNYHYEATDLHEVAAGTQPAEKITYNIMDVVNEKMTTFIQGTVKTIDAATQTVALEDGQTINYDYLVVSLGFESESFGIPGVQEHALQMVDVKTALNVYEHIQEQMRQYKATQNEEFLKIVVCGAGFTGIELLGSLVENKPKFAEIAGVSADQIQIYCVEAVTRLLPMFNEKLANYGVQLLKDSAIHLLLGKPIKEIKPGAVVYQDNEAGDLAELSAKTIIWTTGVSGSHVVGDSGFEARRGRVMVQPDLTDANHSNVYIIGDCSAVMDTETNRPYPTTAQIALKMGAHAAKNIQAQLKGEATKPFSFKSQGSVCSVGNTRALGIVGKTDIKGYPASFMKKIIMNKALFETGGTKEMMAKGRFDLYH
>NZ_CP022712.1|WP_002380448.1|782583_785007_-|DNA-translocase-FtsK
MAQKRSTNKKKSTTKKKTKKQQQQQERLNYMFLGLIFILFGVFGLFRLGFLGTLLANCLRLVVGNTFPFAAILLILYGLLVMIYGKDFPLKRGRPIFGAVLIYISVLLLFHAFMFRNVSGSQPDILGNTWEFLQSDLKANQVTQNVGGGMIGALLYQGTYFLVAQFGSYLIATLLLLAGIFLMSMWDFQQIVDHFQSIQDRLSHVSAKSQARQEEKEAKRAAKKEAKAAERQAKIEAAAQQKLQERERMEQAAAERLTKTPVETHQPMVEEPATPTPVQIDSFQQQNQAMPVPPIAATKPQREQEEEAADEAGVLEFEISEEAEDRDYQLPPTDLLDTIQATDQSGEYEKIEKNIGVLEQTFKSFGVDAKVVKASLGPSVTKFEVQPAVGVKVSKIVNLTDDIALALAAKDVRMEAPIPGKSLIGIEVPNSAISTVSFRDIVEAQPSHPDKLLEVPLGRDISGMVQTADLSKMPHLLIAGSTGSGKSVAINGIITGILMQAKPHEVKLMMIDPKMVELNVYNGIPHLLTPVVTNPRKAAQALQKVVQEMEFRYEKFAATGVRNITGYNQLIQQKNAEDGENRPILPFIVVIVDELADLMMVASNEVEDAIIRLAQMARAAGIHMILATQRPSVDVITGIIKANVPSRMAFAVSSGTDSRTIIDTNGAEKLLGRGDMLFLPMGENKPIRIQGAFISDQEVERVVAFVTDQQEAEYQESMMPTDEPTTSGGGEAPQDELFEEAKNLVVEMQTASISLLQRRFRIGYNRAARLVDELEAHGVIGPSEGSKPRKVFLQAESEEAAPETPEQ
>NZ_CP022712.1|WP_002364244.1|781751_782453_-|GntR-family-transcriptional-regulator
MRRKSVLYLEVADQIKEDILSGKYPVGTFLPTETELEELFNVSKITIRRAIEMLATEEFVEKKSGRGTTVLSNRPYNKLSKAGTFTEFLNESGQKVTKKVLQVENLTLSKEMPAYQFLGEEVVHLSRLYLIDEQPYIYFNYYLPAAMKDVSLTEYKEESLYRLMDRHAIEIYKFEDRFEVATLTEAEQKMLQTTETTGLKRIRRSLSPTGRCVEYSEAIYNTKIHPYVIEYEA
>NZ_CP022712.1|WP_002381711.1|780884_781634_-|ABC-transporter-ATP-binding-protein
MLEVQNLKKVYGNEIKYEALKGINLTVQDGEFIGIMGPSGSGKSTLLNLLATIDSPTDGEILLNGKNPNNLNQEQIAKFRRTELGFVFQSFNLMPTLTVEENIILPLTLDGEKVSVMKRQLAELSERLGINHLLKKRIAEISGGQAQRVAVARAMIHHPQLLLADEPTGNLDTKSSKDVMGLLQQLNEEEAATILMVTHDPLAASYCKRIVFIKDGELIDEIVQNGNQKEFYDLIMVKLAEIEGVDNEF
>NZ_CP022712.1|WP_002380451.1|795440_796304_-|AraC-family-transcriptional-regulator
MLANLNQAMDYIEEHLTEEVSFDELAKKTGISVYHFKRTFSFIAGMSLAEYIKKRRLAEANLALLAGEKVTDVAFKYGYQSIEGFSRAFRDWSGQAPSEVMKTQIQKTFPKFSFYIDIKGGQSMDVKLIEKPAFQIVGVSQKVPLQYQGENQAIMELAQRITPQQRAEMHTFDDIYPHQVVNASFDFQEGRTTEGGEMTHMIGFATSQENTYKDLEQLSVPTHTWAVFPNEGPFPQTLQETWARIFSEWLPSSGYQVVAAPEISFTQYQGPAEAKYSEIWLAVTATK
>NZ_CP022712.1|WP_002380452.1|796388_798470_-|DNA-topoisomerase-III
MVAKQLIIAEKPSVAKDLSRVLGANQKNKNYYEGPNVIVTWALGHLLGLKMPEDLNKEWQTWQMETLPMIPKNLGIKPLPKTGHQLKAIKQLANRKDVSEAVIATDAGREGELVARWILEYVRFNKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNLYYSALARAKADWLVGLNVTRALTVKYQDNLSAGRVQTPTLAMVRQQEKTIEQFKPQTYFTISLTVESEKAKMTQKNPYALKERQEAEQLVKELSKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSLYETHKIVSYPRTDSKYLTTDMKGTMKERLQAIADFSPEVKGYLKNGAVVKQQKVFQNAKVTDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLFAEPNQTKQTKVTVAFGKETFVFHQNKVVVAGWKTTAEQPLSTVQWQKGMTVAPNFTINKELTSPPKPLTEGTLLGKMEKHSLGTPATRAEIIEKLIKSELMERTNSGLSISAKGKQLLDLVNPSLVTPELTEKWEKSLEAIASGQQKSQLFLKDIEEDTKKLVREIKQSEKKYQDFSITQKKCPDCGSNLREKNTKDGKIYVCTNQECSYRRRKDPKVSNHRCPQCHKKMVIIEGKNGRSFKCKFCSITEKIPDKKERKQKMTKHEERRLMKKYSQPDEPEESALAQALKAAMNQE
>NZ_CP022712.1|WP_002356966.1|798600_798966_-|DUF1033-family-protein
MYQVITMYGDNEPWWFFDDWQEDIVQEKTFDNLTDAETYYVEVWQKLSQNYTYVNTKPNYLTAFWNDGEERWCEECDEDLQQYFGLALLENHHAVTFENKAEFTTISNHFGKTKFCKRKVI
>NZ_CP022712.1|WP_002379584.1|799063_799633_-|TetR/AcrR-family-transcriptional-regulator
MAKKRNLTKAKILESARNLAEELGVQQLTFQNLAVDLGIKYPSLYNHFKNIAEVKNALVDLLIQELNDALRRALVGKSGAEAIRIYAETYQQFAFENSAVYELLISVPKTQNQQLIEGIHETNQIILQLLAFYPFNNEERLHKSRELRSLIHGYITLRFLGYFQREEATPEESYRRMIEDFIVSLEVAG
>NZ_CP022712.1|WP_002356963.1|799765_800281_+|YbhB/YbcL-family-Raf-kinase-inhibitor-like-protein
MHITNRSHLADRYGKRTSAEFLLHERPILSFPISLAAIPKEARYLSWELIDYDTIPLIGFPFIHWLAANVPVTNEIPEDFSRTALKPTIQGKNSLASPLGKQMIPALATETLPELTERYLGLSPRSGVHTYTLYVYATKNPLNLKEGFFANELHQALNDQLLAKAKFEFLY
>NZ_CP022712.1|WP_002360011.1|800297_801536_+|multidrug-efflux-MFS-transporter
MYELIKSKIFRPRQPWEKNLLVLWFGTFMAGIGFSLVMPFMPLYINTLGTFTHQQLNFWSGITFSSTFLVTTIVSPWWGRLADRKGRKLMLLRASLGMAIVISLMGAVTSVYQLIGLRLLQGVFSGYISNATALVATGTPKEKSGQVLGTLATGSVTGTLLGPLLGGVTASIFGYRPTFFITGTILLLVFVLSLVFVHEEFVPIEKNQAASGKQILKKLEHPHVILGMFITTLIIQASNNSISPIISLYIQQLLGGHGNVTLISGVIASIPGIATLIAAPRFGRLGDRIGSERILTIGLILAIFVYLPMAFVQNVWQLAMLRFLVGISDACLLPAVQTLITRYSPSDAAGRIFSYNQSFQATGNVIGPMIGSSVSAAFGYRGVFISTSCLVLINLLWVRRSTAELKKEKNDA
>NZ_CP022712.1|WP_065536071.1|801715_802840_-|tRNA-2-thiouridine(34)-synthase-MnmA
MADNSKTRVVVGMSGGVDSSVTALLLKEQGYDVIGIFMKNWDDTDENGVCTATEDYKDVAKVADQIGIPYYSVNFEKEYWDRVFEYFLAEYRLGRTPNPDVMCNKEIKFKAFLDYAMQLGADYVATGHYAQVETDENGVVHMLRGIDNNKDQTYFLSQLSQAQLAKTMFPLGGMEKSEVRAIAERAGLATAKKKDSTGVCFIGEKNFKEFLSNYLPAKKGNMVTEDGEIKGQHDGLMYYTIGQRQGLGIGGGGKTQEPWFVIGKDLTTNTLYVGQGFHNEKLYATHLEASEVHFTVDTPMPKEFDCTAKFRYRQADIPVHVSLSEDGTKATVTFKEPARAVTPGQAVVFYDGMECLGGGLIDRAYQDEKELQYV
>NZ_CP022712.1|WP_002356959.1|803065_803410_-|DUF1831-domain-containing-protein
MAFTTTAAVEGSTVFYKVHPSAKRYTLKDNGFTETKSGNFQLIRSLDPTPQRNEGFKLKITITADLKELKMSITTANGLKPMNIFKNEQHEMSKEKYFFLMDGLISRGVLEKVE
>NZ_CP022712.1|WP_002378485.1|803477_804623_-|cysteine-desulfurase
MEPIYLDHAATTPLHPTVIQAMTENMQTTFGNPSSIHQFGRKAHGLLEEVRQMIAESLQAKPHEIIFNSGGTEGDNTAILAVAFSRQKEGKHIITTAIEHPAVLRTMEYLETLGFEVTYLPVNENGQISMDQFKKSLREETILVSMMYGNNEIGNRLPIAEVGAILKNHSAIFHTDAVQAYGSEVILPHELGIDLLSISAHKINGPKGVGFLFKSDAIQLPPLLHGGEQEEKRRAGTENLAGIIGMGTAVSLLTSAEKQARKTAYQSFQTIILKALEEANIDFSINGEPTNRLAHVLNLHLKGIPSDLLLMHLDLRGIAISTGSACTAGTVDPSHVLTAMYGENSSAIKESIRISFGYGNTPEEIATFSEVLVAVIQQLKK
>NZ_CP022712.1|WP_002362076.1|804779_805754_-|ribose-phosphate-diphosphokinase
MTENYQDDTLRIFSLNANRPLAEKIAASVGTELGKSTVRQFSDGEIQINIEESIRGDHVYIIQATNAPVNDHLMELLILIDALKRASAKTINVILPYYGYARQDRTAKPREPITAKLVANMLVEAGATRLLTLDLHTVQVQGFFDIPVDNLFTMPLFAHYYRQQALVGEEIVIVSPKNSGVQRARSLSEYLDATLAIVDHEEIDGVRQEGYVIGNVAGKKCILVDDILNTGQTLATAAEVLMKNGAQEVYACASHGLLSEGAKATLENAPIKEISITDSVYTTADRQPATLNIISCAELMGEALLRIHENKPMSPLFRLEPKGE

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Crispr_ID: NZ_CP022712_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022712_2

1001395-1001508

Orphan

Consensus_repeat	Method
ACAACGTTCCCTTTGGTCACCTTGTGCTGTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022712_2

>merge|NZ_CP022712|2|1001395-1001508|CRISPRCasFinder
ACAACGTTCCCTTTGGTCACCTTGTGCTGTTCCACATCTACTCCATGTTTTTGGCTAAGCAGTTTGTTTTAACATAGAGGAGACAACGTTCCCTTTGGTCACCTTGTACTGTTC

>NZ_CP022712|2|2|1001395-1001508|CRISPRCasFinder
ACAACGTTCCCTTTGGTCACCTTGTGCTGTTC	CACATCTACTCCATGTTTTTGGCTAAGCAGTTTGTTTTAACATAGAGGAG
ACAACGTTCCCTTTGGTCACCTTGTACTGTTC

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022712.1\|WP_002356744.1\|1004474_1006673_-\|HDIG-domain-containing-protein	unknown	unknown	gnl\|CDD\|224397
NZ_CP022712.1\|WP_002380583.1\|995571_996348_-\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
NZ_CP022712.1\|WP_002389231.1\|1006701_1007676_-\|phosphate-starvation-inducible-protein-PhoH	unknown	unknown	gnl\|CDD\|224616
NZ_CP022712.1\|WP_002356746.1\|1003610_1004018_-\|diacylglycerol-kinase-family-protein	unknown	unknown	gnl\|CDD\|260134
NZ_CP022712.1\|WP_002370425.1\|998093_1000178_-\|glycine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234925
NZ_CP022712.1\|WP_002359745.1\|1002694_1003597_-\|GTPase-Era	unknown	unknown	gnl\|CDD\|234624
NZ_CP022712.1\|WP_002356760.1\|993158_994040_-\|elongation-factor-Ts	unknown	unknown	gnl\|CDD\|236491
NZ_CP022712.1\|WP_002356759.1\|994145_994931_-\|30S-ribosomal-protein-S2	unknown	unknown	gnl\|CDD\|235396
NZ_CP022712.1\|WP_002380585.1\|1003995_1004475_-\|rRNA-maturation-RNase-YbeY	unknown	unknown	gnl\|CDD\|234575
NZ_CP022712.1\|WP_002356756.1\|996454_996730_+\|acylphosphatase	unknown	unknown	gnl\|CDD\|224174
NZ_CP022712.1\|WP_002356740.1\|1008333_1008510_-\|30S-ribosomal-protein-S21	unknown	unknown	gnl\|CDD\|234707
NZ_CP022712.1\|WP_002382760.1\|1009214_1010072_+\|kinase/pyrophosphorylase	unknown	unknown	gnl\|CDD\|377080
NZ_CP022712.1\|WP_002356755.1\|996896_997829_+\|membrane-protein-insertase-YidC	unknown	unknown	gnl\|CDD\|235040
NZ_CP022712.1\|WP_002379669.1\|1000179_1001088_-\|glycine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|236473
NZ_CP022712.1\|WP_002356761.1\|992175_992898_-\|UMP-kinase	unknown	unknown	gnl\|CDD\|239787
NZ_CP022712.1\|WP_002356753.1\|997862_998054_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|181104
NZ_CP022712.1\|WP_002387080.1\|1008675_1009116_-\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|133478
NZ_CP022712.1\|WP_002356741.1\|1007858_1008308_-\|GatB/YqeY-domain-containing-protein	unknown	unknown	gnl\|CDD\|370480
NZ_CP022712.1\|WP_002356748.1\|1001823_1002612_-\|DNA-repair-protein-RecO	unknown	unknown	gnl\|CDD\|273175
NZ_CP022712.1\|WP_002367049.1\|995114_995552_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|236715

Protein	Function_ID	Function_description	E-value
NZ_CP022712.1\|WP_002356744.1\|1004474_1006673_-\|HDIG-domain-containing-protein	gnl\|CDD\|224397	COG1480, COG1480, Predicted membrane-associated HD superfamily hydrolase [General function prediction only].	6.87785e-159
NZ_CP022712.1\|WP_002380583.1\|995571_996348_-\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	2.51292e-71
NZ_CP022712.1\|WP_002389231.1\|1006701_1007676_-\|phosphate-starvation-inducible-protein-PhoH	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	4.35931e-144
NZ_CP022712.1\|WP_002356746.1\|1003610_1004018_-\|diacylglycerol-kinase-family-protein	gnl\|CDD\|260134	cd14265, UDPK_IM_like, Integral membrane undecaprenol kinase and similar enzymes. This mostly bacterial family of homo-trimeric integral membrane enzymes, the products of the dgkA gene, catalyzes the ATP-dependent phosphorylation of undecaprenol to undecaprenyl phosphate. C55-isoprenyl (undecaprenyl) pyroposphate acts as a scaffold for the assembly of peptidoglycan components; undecaprenol kinase (UDPK) is involved in recycling undecaprenyl units for re-use in the peptidoglycan biosynthesis. UDPK does not participate in the de-novo biosynthesis of undecaprenyl phosphate. Gram-positive bacteria have a large pool of free undecaprenol, in contrast to gram-negative bacteria. UDPK may also play a role in a stress-induced pathway that affects the function of ribosomes. In Streptococcus mutans, UDPK has been shown to be required for biofilm formation, such as in the case of smooth surface dental caries. Members of the UDPK family have low activity as diacylglycerol kinases (DAGK), and many of them are annotated as DAGKs.	2.85033e-42
NZ_CP022712.1\|WP_002370425.1\|998093_1000178_-\|glycine--tRNA-ligase-subunit-beta	gnl\|CDD\|234925	PRK01233, glyS, glycyl-tRNA synthetase subunit beta; Validated.	0
NZ_CP022712.1\|WP_002359745.1\|1002694_1003597_-\|GTPase-Era	gnl\|CDD\|234624	PRK00089, era, GTPase Era; Reviewed.	0
NZ_CP022712.1\|WP_002356760.1\|993158_994040_-\|elongation-factor-Ts	gnl\|CDD\|236491	PRK09377, tsf, elongation factor Ts; Provisional.	1.02636e-146
NZ_CP022712.1\|WP_002356759.1\|994145_994931_-\|30S-ribosomal-protein-S2	gnl\|CDD\|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	3.78425e-167
NZ_CP022712.1\|WP_002380585.1\|1003995_1004475_-\|rRNA-maturation-RNase-YbeY	gnl\|CDD\|234575	PRK00016, PRK00016, metal-binding heat shock protein; Provisional.	8.00786e-61
NZ_CP022712.1\|WP_002356756.1\|996454_996730_+\|acylphosphatase	gnl\|CDD\|224174	COG1254, AcyP, Acylphosphatases [Energy production and conversion].	1.58992e-26
NZ_CP022712.1\|WP_002356740.1\|1008333_1008510_-\|30S-ribosomal-protein-S21	gnl\|CDD\|234707	PRK00270, rpsU, 30S ribosomal protein S21; Reviewed.	8.30263e-11
NZ_CP022712.1\|WP_002382760.1\|1009214_1010072_+\|kinase/pyrophosphorylase	gnl\|CDD\|377080	pfam03618, Kinase-PPPase, Kinase/pyrophosphorylase. This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity.	4.76001e-139
NZ_CP022712.1\|WP_002356755.1\|996896_997829_+\|membrane-protein-insertase-YidC	gnl\|CDD\|235040	PRK02463, PRK02463, OxaA-like protein precursor; Provisional.	1.42463e-134
NZ_CP022712.1\|WP_002379669.1\|1000179_1001088_-\|glycine--tRNA-ligase-subunit-alpha	gnl\|CDD\|236473	PRK09348, glyQ, glycyl-tRNA synthetase subunit alpha; Validated.	0
NZ_CP022712.1\|WP_002356761.1\|992175_992898_-\|UMP-kinase	gnl\|CDD\|239787	cd04254, AAK_UMPK-PyrH-Ec, UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and via gene repression of carbamoyl phosphate synthetase (the first enzyme of the pyrimidine biosynthesis pathway). The UMP kinase of E. coli (Ec) is known to function as a homohexamer, with GTP and UTP being allosteric effectors. Like other related enzymes (carbamate kinase, aspartokinase, and N-acetylglutamate kinase) the E. coli and most bacterial and chloroplast UMPKs (this CD) have a conserved, N-terminal, lysine residue proposed to function in the catalysis of the phosphoryl group transfer, whereas most archaeal UMPKs appear to lack this residue and the Pyrococcus furiosus structure has an additional Mg ion bound to the ATP molecule which is proposed to function as the catalysis instead. Members of this CD belong to the Amino Acid Kinase Superfamily (AAK).	1.02758e-148
NZ_CP022712.1\|WP_002356753.1\|997862_998054_-\|hypothetical-protein	gnl\|CDD\|181104	PRK07758, PRK07758, hypothetical protein; Provisional.	6.66934e-06
NZ_CP022712.1\|WP_002387080.1\|1008675_1009116_-\|transcriptional-repressor	gnl\|CDD\|133478	cd07153, Fur_like, Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators. Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.	4.90593e-35
NZ_CP022712.1\|WP_002356741.1\|1007858_1008308_-\|GatB/YqeY-domain-containing-protein	gnl\|CDD\|370480	pfam09424, YqeY, Yqey-like protein. The function of this domain found in the YqeY protein is uncertain.	1.89434e-63
NZ_CP022712.1\|WP_002356748.1\|1001823_1002612_-\|DNA-repair-protein-RecO	gnl\|CDD\|273175	TIGR00613, DNA_repair_protein_RecO, DNA repair protein RecO. All proteins in this family for which functions are known are DNA binding proteins that are involved in the initiation of recombination or recombinational repair. [DNA metabolism, DNA replication, recombination, and repair].	6.18949e-71
NZ_CP022712.1\|WP_002367049.1\|995114_995552_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|236715	PRK10562, PRK10562, putative acetyltransferase; Provisional.	1.03251e-32

>NZ_CP022712.1|WP_002379669.1|1000179_1001088_-|glycine--tRNA-ligase-subunit-alpha
MKNKLTVQEMILTLQKFWSSNGCMLMQAYDTEKGAGTMSPYTFLRAIGPEPWNAAYVEPSRRPADGRYGENPNRLYQHHQFQVVMKPSPENIQELYLESLKLLGIDPLEHDIRFVEDNWENPSMGCAGLGWEVWLDGMEITQFTYFQQVGGLQCHPVTSEITYGLERLASYIQEVESVYDLEWTQGVKYGEIFVQPEYEHSKYSFEISNQEMLLENFDKFEKEAKRCIEESLVHPAYDYILKCSHTFNLLDARGAVSVTERAGYLARIRNMARSVAKIFVAEREKLGFPLLNKDQSVSKEAE
>NZ_CP022712.1|WP_002370425.1|998093_1000178_-|glycine--tRNA-ligase-subunit-beta
MAKDLLLEIGLEEMPAHVVTPSRIQLEEKVIKFLDEHHLDYETVQSFATPRRLAVKVTAIPEKQADVEEEVKGPAKKIALDAEGNWSKAAQGFVRGQGVTTEDIVFKELNGVEYVYVTKFTKGQSAKEVLTKLNDVITSLTFPVTMHWANYDFEYIRPIHWIVALLDDEVIPFKVLDVTTGQTSRGHRFLGDDVTFQHANEYEAKLKEQFVVVQPNERKQMIVDQANALAAEKNWQLALDEELLEEVTNLVEYPTAFVGSFDEKYLSVPDEVLVTSMKEHQRYFEVRNDQGLLMPHFIAVRNGDNVHLENVIKGNEKVLIARLEDAEFFYNEDKKLTIEACVEKLKNVTFHEKIGSIYEKMQRVALIAQIIGRKVGLSEEELEDLKRASEIYKFDLVTNMVGEFPELQGIMGEKYALLQGEKPAVATAIREHYLPTSSEGELPETAIGAVLALADKLDSVFSFFSVGMIPTGSNDPYALRRQTYGVIRIIEDKGWTFPLVQLQTEVDEAVNQDVEKYGVLLNEGQAEVVEFVKARLRQLLMTKNVRHDIIDAVVSAEQADLSKLFASANILKSRFEDQDFKPSMEALTRVINLAKKGQELLGDTEEGIDPSLFENKAEKELYQAVNDLSEAFATRTIAENYEALVNLRPLIDAYFNETMVMVEDEKVKQNRLKQLMQIAKMALSIASLDLLIVK
>NZ_CP022712.1|WP_002356753.1|997862_998054_-|hypothetical-protein
MLETTFEQILTQLSKPAVRALTNEKIDSVDELYARGRKALLSLHGFGPKSIRTIEEMTGKELK
>NZ_CP022712.1|WP_002356755.1|996896_997829_+|membrane-protein-insertase-YidC
MRKLNRWLYGSGLLFLVMFLSGCVKTGADGQPTGEGFVYNFLVLPMSNAITYLVDNFNWNYGWAIIFITIIVRIIILPLGLHQSKKSFIQTEKMQAIKPQVDVAQAKMKQASTREEQMAAQAELQKIYKENNVSMVGGIGCLPLLIQMPIFSSLFFAARYTKGIATASFLGMNLGQPNMILVALAGLAYLAQGYISMIGIPEEQKKTMKSMLIVSPLMIVFMSFSSPAGVALYWVVGGIFTCIQSAITNILLRPRIKKQVQEELKNNPPKQVVTPIKDVTPKETNKVTQKTNQPKANGNKGRNAGKQKRK
>NZ_CP022712.1|WP_002356756.1|996454_996730_+|acylphosphatase
MEKLRMNVQGRVQGVGFRYMTKMVADQLGVTGSVKNEDDGSVSITAIAPEDIMETFIKKIKDSPSPAGRVTYVDIQEDPLLEETEQFKVIQ
>NZ_CP022712.1|WP_002380583.1|995571_996348_-|RNA-methyltransferase
MKEITSTKNNQLKEWKKLHKKKYREELNQYIIEGFHLIEEAVKANADVQWILFNQRGQQEWGTWLAEQETEKLIFVSDEVLNSLSELPTSQGILAIVTLETQQEQSLSFKGGWLLLDNIQDPGNVGTMIRTADAAGLAGVILGKGTADIYNTKVLRSMQGSHYHLPVLQRELTEVVQAFKKQGLPVFGTELNEAAIAYYEQEAVENYALILGNEGSGVSPELLAETTKNLYIPMKGQAESLNVAIAAGVLMFYFENNQ
>NZ_CP022712.1|WP_002367049.1|995114_995552_-|GNAT-family-N-acetyltransferase
MLTIKKTTQLTEKELETIMAIWLQTNLEAHPFVAPTYWQENKAFVRAALPKATLILAEEEGQIIGFLGLMDNYIAGIFIKKAFQGKGIGQKLLQVAKEEQDLLSLAVYRKNQAAYAFYQKQGFVQQKRTIDETGNEECHLVWQAQ
>NZ_CP022712.1|WP_002356759.1|994145_994931_-|30S-ribosomal-protein-S2
MAVISMKQLLEAGVHFGHQTRRWNPKMKKYIFTERNGIYIIDLQKTVKLVDAAYDYMKNVAEEGGVALFVGTKKQAQEAIKDEAIRAGQYYVNHRWLGGTLTNWDTIQKRIARLKKINAMEEDGTFEVLPKKEVAGLNKERERLEKFLGGIADMPRIPDVMYIVDPRKERIAVQEAHKLNIPIVAMVDTNCDPDEIDVVIPSNDDAIRAVKLITAKMADAFIEGNQGEDQATEELFVEETPEATSIEEIVDVVEGNNESAE
>NZ_CP022712.1|WP_002356760.1|993158_994040_-|elongation-factor-Ts
MADVTAKMVKELRDMTGVGMMDAKKALVKVEGDMEKAVDFLRENGMAKAAKKNDRIAAEGLANVATVGNVAAIVEVNSETDFVSKNEMFQDLVKDIATKVAENKPATMEEAMAIKTEKGTIESDLIEATTVIGEKISFRRFEVVEKADNAAFGAYLHMGGRIAVLTVIDGTTDEEVAKDVAMHIAAINPRYVNESQIPQEELEHEKAVLTEQALNEGKPANIVEKMVVGRLQKFKAEIALVDQPFVKDPDMTVEKFVASKGGEVKSFVRFEVGEGIEKREDNFADEVMSQMKN
>NZ_CP022712.1|WP_002356761.1|992175_992898_-|UMP-kinase
MVKPKYQRVVLKLSGEALAGEDGFGIKPPVIKEIVQEIKEVHELGIEMAIVVGGGNIWRGQIGAQMGMERAQADYMGMLATVMNALALQDTLENLGVPTRVQTSIEMRQIAEPYIRRRAERHLEKGRVVIFAGGTGNPYFSTDTTAALRAAEVDADVILMAKNNVDGVYSADPRVDETATKFEELTHLDVISKGLQVMDSTASSLSMDNDIPLVVFNLNEAGNIRRAILGENIGTTVRGK
>NZ_CP022712.1|WP_002356748.1|1001823_1002612_-|DNA-repair-protein-RecO
MALGETKGIILFTKDFKEKDKLVKIFTESYGKLMFFVKGAHRKNNPLLPAILPFTEAVYIGNFREEGLSFLNSSKEVQPFRNIQQDIFINAYGTYILNLVDAAIEDQHYDPNLFQFTHMALSALNEQKDPEIITNIFEIQLLERFGVRPEWHHCVACGETQGKFDYSSKYSGVLCEKHWHLDEQRYHADPRAIHFIRLFAQVSYEKVQNIQVKEETKKSIRETIDMLYDEYVGLHLKSKKFIDQMKTWENTLKIPPRKKEEK
>NZ_CP022712.1|WP_002359745.1|1002694_1003597_-|GTPase-Era
MTTEHKSGFVAIVGRPNVGKSTLLNRIVGQKIAIMSDKAQTTRNKIQGIYTIPEAQIVFIDTPGIHKPKHRLGDFMVESAYNAMREVDATLFMVSADQKRGKGDDFIIERLKNNNSPVYLIINKIDKVHPDDLLSIIEDYSKQMDFKEIIPISATEGNNFEHLMDVLVEQMPEGPQYFPDDQITDHPEYFIVSELIREKVLLLTRDEIPHSVAVVVDSMKRDENDKVHVQATIIVERDSQKGIIIGKGGKMLKQIGTKARQDIEYLLDDKVYLELWVKVQKDWRDKKIYLQDFGYRKEEY
>NZ_CP022712.1|WP_002356746.1|1003610_1004018_-|diacylglycerol-kinase-family-protein
MRMALKDEQTGKNKHFINSLEFAWQGIKTVFREERNMRKHVAFGVTAIVFGFLFSLTLAEWLWLLLAVFLVWLAEIINTIFENVVDMFTDFHFHPIGKKVKDMAAGAVLLTAGFAVLVGLILFVPKILQIIQMWK
>NZ_CP022712.1|WP_002380585.1|1003995_1004475_-|rRNA-maturation-RNase-YbeY
MDITFIDETEKVPTEEIKEIENLLQFAAGFLEIAEDTEMSVTFTDNAGIQVINRDYRGKDMPTDVISFALEDEGENELPIIFDDEELAELPRNLGDLIISTERAAEQAVEYGHTLEREMGFLAVHGFLHLNGYDHMEPEDEKEMFGLQKEILDAYGLKR
>NZ_CP022712.1|WP_002356744.1|1004474_1006673_-|HDIG-domain-containing-protein
MKKVLTKLGDRLGKAYLPILLAVFSLLLFMIMFGSVHQKRVEIKEGQLAEKTIRANKNIENTYETEQRKKLAAEAVTPEYIYQEDTASVQHNRIDKLFKLIDSANEKVDKEYSNKQAKAKKEETIPAPTVEERVASLKSLFESLPQDEVTFYQSFPNVFYQTIFTLTSEQLDKVRSESLMLVDDAMQNHVRESDLDKIRQEANGKIQYLDITSTMQQVIRYIVNQGIVVNDIANEKRTEELRQKAMNAVQPAMIYQGEIIVREGTQIDAKAVEKLELLGMTSQNTSIFPMVALALAILLQVEVLIFFTKQVTEPSRQRSFIIFYTGAMLISVILMKFFQIFQTEQLMYIPLFYPAAFAPLILNHFVNRRSGIIAAIFQVVFALFIFYNSIGTNSLTVILIMYLFSGFLATVVKRKRMSEQVFPALMWVVVFPVFMAVVLMIYQGMSLTDGKTWTALICASAGTVLSFLATMGLHPYIELLVTDDSMIVLNELSNPNHPLLKQLLEEAPGTYHHSMMVASLSANAVAEIGGRSLLTRVACYYHDIGKIKHANFFVENLPAGAENPHNFLLPEDSKQIIFGHVIDGAKILEEYNMPQMVIDICRQHHGTTLMKFFYVKAKERNPEIKESDFRYPGPRPQTREAGIVSIADTCEAAVRAMDHPTNEKIQAFVHNVIQDRISDGQLDECGLTMKEIRIIEKSLINGLCSTFHSRIKYPKMKAEAEEMKDEQEKRDD
>NZ_CP022712.1|WP_002389231.1|1006701_1007676_-|phosphate-starvation-inducible-protein-PhoH
MTDNQSKSLELILTDSDDAHMLLGTHDKHIKFLEENTHVTINSRGEVIQLIGESSEVELVASVLRALQTLIQRGIKVHTPDVVSALKMAKAGNLEAFIAMYEEEIMKDHHGRAIRIKNVGQKKYIDAVKTHDVIFGVGPAGTGKTFLAVVMAVAALKKGEVQKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYQIFGMDHTNRLMERGVIEIAPLAYMRGRTLDDAFVILDEAQNTTVAQMKMFLTRLGFSSKMIVNGDTSQIDLPRGVTSGLVNAERTLKDIEKIAFVNFEASDVVRHPVVAQIIQAYEKEQQKHS
>NZ_CP022712.1|WP_002356741.1|1007858_1008308_-|GatB/YqeY-domain-containing-protein
MSLLTTLNDDIKTAMKAKDKETLAVLRMLKTAIQNDQIKAGRELNGEEELTVLSREMKQRKDSLSEFEKAGRDDLVEKVKVEIAIVEKYMPQQLTEEEIRQLVQEVMTQTGATSPKDFGKVMGAMMPKVKGKADGNQVNAIVKELLQEN
>NZ_CP022712.1|WP_002356740.1|1008333_1008510_-|30S-ribosomal-protein-S21
MSKTVVRKNESLDDALRRFKRSVSKAGTLQESRKREFYEKPSVKRKKKSEAARKRKKF
>NZ_CP022712.1|WP_002387080.1|1008675_1009116_-|transcriptional-repressor
MAMAPVKTNIEQALETMKASGLKYTKKRELLMSYLIKRNRYVSAREVYEFMNETFKGVSYDTVYRNLHDFERLELLEKTELNGEQKFRFRCCQEVEHHHHFICTVCGKTEEIHMCPMNFFEEQLKGCSIEGHRFEILGRCADCCEK
>NZ_CP022712.1|WP_002382760.1|1009214_1010072_+|kinase/pyrophosphorylase
MTISEEKKCVTIFVISDSAGETASKLAAASMAQYPTVDFTLIRRTFVKDEDKLVQALEDAKKAEAMVLHTIINDHLVAIANQFFNEHQLFHFDILTPPVAEIERLTGVAPMREPGALHHLNENYFKRIEAMEFAVKYDDGKDPRGFLEADVLLLGVSRTSKTPLSLFLANKNLKVANLPLIPEAHLPKQLFEMDPKKIVGLTNDPNVLNGIRKERMRAYGLPENTSYSDIEKIRRELAFANDLYQKLGCIVIDVASLSIEETASMILNALNLEDHSYYSTETSED

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Crispr_ID: NZ_CP022712_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NZ_CP022712_3

1418631-1418709

Orphan

Consensus_repeat	Method
GTAGGTTCTGGGGTAGGTGTTGGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NZ_CP022712_3

>merge|NZ_CP022712|3|1418631-1418709|CRISPRCasFinder
GTTGGATCTGGGGTAGGTTCTGGGGTAGGTGTTGGTTCTGGCGTTGGACCCGGAGCTGGTGTCGGATTAGGCGTTGGTT

>NZ_CP022712|3|3|1418631-1418709|CRISPRCasFinder
GTTGGATCTGGGGTAGGTTCTGGGG	TAGGTGTTGGTTCTGGCGTTGGACCCGGA
GCTGGTGTCGGATTAGGCGTTGGTT

Protein	Signature genes	Signature genes Name	Protein_function
NZ_CP022712.1\|WP_002410060.1\|1421877_1422285_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022712.1\|WP_002371428.1\|1422868_1424377_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224588
NZ_CP022712.1\|WP_002393071.1\|1424747_1425074_-\|nucleotidyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|376187
NZ_CP022712.1\|WP_002393069.1\|1419584_1420196_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022712.1\|WP_002371418.1\|1413447_1414434_-\|conjugal-transfer-protein	unknown	unknown	gnl\|CDD\|372237
NZ_CP022712.1\|WP_002371421.1\|1415560_1418308_-\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|380024
NZ_CP022712.1\|WP_002371434.1\|1425846_1426035_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022712.1\|WP_002371420.1\|1414878_1415421_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022712.1\|WP_002371416.1\|1413223_1413448_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022712.1\|WP_002371424.1\|1420273_1421557_-\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367101
NZ_CP022712.1\|WP_065535846.1\|1404146_1405958_-\|group-II-intron-reverse-transcriptase/maturase	RT	pfam00078_RT_CAS-I:CAS-III	gnl\|CDD\|275209
NZ_CP022712.1\|WP_002371410.1\|1409669_1412174_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|315512
NZ_CP022712.1\|WP_002371408.1\|1407602_1409654_-\|ATP-synthase-F0,-A-subunit	unknown	unknown	gnl\|CDD\|376803
NZ_CP022712.1\|WP_002371426.1\|1422294_1422582_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022712.1\|WP_029645162.1\|1425133_1425427_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022712.1\|WP_002371429.1\|1424377_1424758_-\|DUF86-domain-containing-protein	unknown	unknown	gnl\|CDD\|366864
NZ_CP022712.1\|WP_002371414.1\|1412825_1413215_-\|conjugal-transfer-protein	unknown	unknown	gnl\|CDD\|372239
NZ_CP022712.1\|WP_065536170.1\|1412438_1412747_+\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022712.1\|WP_002380870.1\|1414414_1414882_-\|hypothetical-protein	unknown	unknown	unknown
NZ_CP022712.1\|WP_002371427.1\|1422571_1422850_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NZ_CP022712.1\|WP_002371428.1\|1422868_1424377_-\|hypothetical-protein	gnl\|CDD\|224588	COG1674, FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning].	2.19067e-23
NZ_CP022712.1\|WP_002393071.1\|1424747_1425074_-\|nucleotidyltransferase-domain-containing-protein	gnl\|CDD\|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	1.00944e-12
NZ_CP022712.1\|WP_002371421.1\|1415560_1418308_-\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|380024	pfam17802, SpaA, Prealbumin-like fold domain. This entry contains a prealbumin-like domain from a wide variety of bacterial surface proteins. This entry corresponds to domain 1 and domain 3 of SpaA from Corynebacterium diphtheriae. Some members of this family contain an isopeptide bond.	1.08352e-09
NZ_CP022712.1\|WP_002371418.1\|1413447_1414434_-\|conjugal-transfer-protein	gnl\|CDD\|372237	pfam12642, TpcC, Conjugative transposon protein TcpC. This family of proteins are annotated as conjugative transposon protein TcpC. The transfer clostridial plasmid (tcp) locus is part of some conjugative antibiotic resistance and virulence plasmids. TcpC was one of five genes whose products had low-level sequence identity to Tn916 proteins, having similarity to ORF13 homologs from Tn916, Tn5397, and CW459tet. This family of proteins is found in bacteria. Proteins in this family are typically between 302 and 351 amino acids in length.	4.05254e-58
NZ_CP022712.1\|WP_002371424.1\|1420273_1421557_-\|XRE-family-transcriptional-regulator	gnl\|CDD\|367101	pfam02486, Rep_trans, Replication initiation factor. Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family, including myelin transcription factor 2 and cerebrin-50.	2.9632e-59
NZ_CP022712.1\|WP_002371429.1\|1424377_1424758_-\|DUF86-domain-containing-protein	gnl\|CDD\|366864	pfam01934, DUF86, Protein of unknown function DUF86. The function of members of this family is unknown.	4.23382e-09
NZ_CP022712.1\|WP_002371414.1\|1412825_1413215_-\|conjugal-transfer-protein	gnl\|CDD\|372239	pfam12648, TcpE, TcpE family. This family of proteins includes TcpE a conjugative transposon membrane protein.This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 168 amino acids in length.	1.86941e-21
NZ_CP022712.1\|WP_065535846.1\|1404146_1405958_-\|group-II-intron-reverse-transcriptase/maturase	gnl\|CDD\|275209	TIGR04416, hypothetical_protein, group II intron reverse transcriptase/maturase. Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other].	5.89899e-117
NZ_CP022712.1\|WP_002371410.1\|1409669_1412174_-\|ATP-binding-protein	gnl\|CDD\|315512	pfam12846, AAA_10, AAA-like domain. This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	2.06494e-150
NZ_CP022712.1\|WP_002371408.1\|1407602_1409654_-\|ATP-synthase-F0,-A-subunit	gnl\|CDD\|376803	pfam02508, Rnf-Nqr, Rnf-Nqr subunit, membrane protein. This is a family of integral membrane proteins including Rhodobacter-specific nitrogen fixation (rnf) proteins RnfA and RnfE and Na+-translocating NADH:ubiquinone oxidoreductase (Na+-NQR) subunits NqrD and NqrE.	0.00175375

>NZ_CP022712.1|WP_002371421.1|1415560_1418308_-|LPXTG-cell-wall-anchor-domain-containing-protein
MKFSRKIKNLAMIGVIGLQTLFTAVPVNAVTASDVSFDHNNEREMSVTWKGETRDIWTAPIYLDQGTGKELVFCVDPFSHVLEGTGYSSNPFALNRKANLISSLWNLAGTDLDTMFVAQEMLYNEVGAVVHSNGDLTEEQRMTIKKKINDVIANYEKQPSFHNSKVKLTLGESTVLTDTNGSNLSQFDVVAQNTANVDFRQSGNKLTITPKSTANSSGTLILKKSLREGTPFIWKKSGSQELISSGVSDPSKYKIDFEIVTTGEMKIVKLDKETGKPVPNTKFEVEYNGKKQTVTTDTKGEAIVKNIPHNAKVKATEIFVPAPYVLDKNNTKEVVVKAGKTASVEFKNEVATGKTTLIKEDKTTNSDKPLNPTYPMVGAKYGLFKENGTLLKEFTLDEKLTASMDKLDLGTYYWQETEAPAGYTLDPEKHVVELTYKDQNTPVVIKDSESIDDVIRMNLDGQKVIQNETNEIFKNGVEFTATNERTQEKTVVTTANVDGKNGYFKFGNLPIDDYIITETKGVEGYQSIDPIEVKHSYDKESDTFTFTVTDQKSGNVLNTEQFTQKDLSKGENVDLGTYTLKDKATPIDTPWVDIVSIAHTGDGKTRSFIWGKEVKLYDDVKISHTNIPLGTKRAFEDILVAVTPDNQEKDVWSSGKIDYKVANENMTQRVETNYDYKKDPEGTRYFFKVIGYSKVSDTEYKQDTEHNFDGNQKNQEIIPALPDKPEINISSQAHIGDNKTQTFIWGEKVKLYDNVKISHKNVDVDTERAFETILVAVTPDGKEKDAWTSGKVDYKVTKKDTVQTVQADYDYKKDLKGTRYYFKEIGYNKTKNNKYEKDSEHNIGGKEKTQDITSTVKEVPKKEPKTPSNPKQAEHGLLPYTGEEANIWLIGVGVVLLGSVYALVQYKKRKKHMNK
>NZ_CP022712.1|WP_002371420.1|1414878_1415421_-|hypothetical-protein
MVKELSKEEFVNQYMFDFKSLIFKSNNPEKITAKQEKLLECEMKIAVLFYETYRRMKGYPPDEKELGRIVQRNFLDRLKLFRVEYDVISEEKFCGLHVQMVKQQMPLEKYQADDLSYILGREKKVAANYFLTHDDFPTGYEELMISRSKKVVTHGLEELREKFMERYHKYYRKMERSCIL
>NZ_CP022712.1|WP_002380870.1|1414414_1414882_-|hypothetical-protein
MNQNIMPIFREHSKFYQKYSNVPVPEMLRLHGFIVDEMPIDEADIVYMEEYKNSLFKMGIIIDEAPFKKEFVAQYVFHGGITSLIAEGQYLRKPNGDKMYNSYYFYLYKEGFQTHKGHVRERVYVEKAIKSTFLKTFESCLGLLRVGGEYEFKEN
>NZ_CP022712.1|WP_002371418.1|1413447_1414434_-|conjugal-transfer-protein
MNLKKIKKKEKKEKTPKVKTFSQKKANRVVLIGASVLLVMSGVGALRANVMASNVDNLYSKVDTLSEQSKKNKVDREELDYSTLSFYVENFAKEYLNYNSKASDEAKKARIDRLSKYLSLDVKNVDETENLQGNVLRTFKNTSLSRIEKMEDCYLVYLNVNYELEKDKKTENVTQNMVLPIQVKDNLFSIVGRPYFVASSLPQGKTVPLKQTENSIDVDGKEKQSVEKFLKMFFTKYSVGNKQELMLLMKKPATTAGQDSFVSIDSGDMKFFDTKQKGVTGVQVSVTFSDNTTKLTHTEDFSLWLSKTENSYFINTMKHYFTEKEGND
>NZ_CP022712.1|WP_002371416.1|1413223_1413448_-|hypothetical-protein
MNTGNLSSFLSTGFITILASGAIILILKHWKGAEWAKIGSVIVIALILQDFATNQGKNIFAVVKWFLSLVGIKM
>NZ_CP022712.1|WP_002371414.1|1412825_1413215_-|conjugal-transfer-protein
MKYYDYSRGLKAPYSMQVIKSPKGQVVWVFAQPVSLSYLLILFLGIVLTGLFWKEVPLPQILGINLNLLIMLLMPNKVARWYSEKEFEGKTGFVFLKDGFVYVKNYVLDSRSIVAFERVKEIEEFSFKR
>NZ_CP022712.1|WP_065536170.1|1412438_1412747_+|hypothetical-protein
MRKENVIKFFLYILIPIIIGTIISLFTNAPIFLIAGIIYIILLLFLLPTLDFEITDFNAKQINPSYRPEKKINKNESIVTVLLLVIGIIVCTVMLYLKYKTS
>NZ_CP022712.1|WP_002371410.1|1409669_1412174_-|ATP-binding-protein
MQLEYPLTNHMKGNIVLTQEKTAIAYYRVRSETVMLTDVEKKLKTKRKVARALNRLKANDGFEINLLPVNADIRGKMGAMRSLIDSNNYEVGVDKLMKTAMVLEQEMGMVYEYTWIIGVPLIKKDLAVDLKETVTNSISNVSEKFVKGLGFDVELSECWEKDYREQELEVYQNLSELLIERLSEDELYYYQAYQFLKNIPHERQDVLSSQNLDNLMATKIKPLFGGGLHLNCDYGESYISYLPMGDVGVFLDGNHFLEVVQKMPFPVEVKIQATFAESKGQLALSGRSSRARTRTKNIMQEAHLAGSKQKRKIVEGQLSLDDLDQKIDDGVDIIDWKAVVVVSGSTKKQMRARKKYLINRFDSLDIPLIKATFDNPYLFQSTLFGNFIRMQTSRWQHTSTIESFAELNFFTSLHAGTKLGFYLGRIDTTLEEKEDRKSIISSSKNLIFMNMLLANKQNVDGKKTNNPHWALTGDTGNGKSVTAKTLFMQMALLKDRVLYIDPKKEMRKQFMYTINAPEYQKKYPLDVDFVKSFNFVTLDVRDTKNHGVLDPIVLFNETEATSTAKAMITNVYDGTWNLKQKTASNEAITKVISERKAGKKVGFWHVIELLAESEISDVKDMGRFLLSTIKGSVLELAFSHGEVEGLSFDRKVTILEIEDLDLPTDKNEKLDENKRSSVTLMFALGTFCSKFGSRNPKEETVTFFDESWIFQSSPEGKAILKSMKRIGRSFNNFLVLITQSTNDLDDSEDGTGFGTVICFDEVQNREGVLKYLNLPVNEINMKWVSNMVQGQCLMKDMFGQTNRIVVHVIFEEWLELFKTVDDTEASKMENRFVA
>NZ_CP022712.1|WP_002371408.1|1407602_1409654_-|ATP-synthase-F0,-A-subunit
MQYLIDSYSAYTVDGGLLDKGWQVVNWFFVDIPFFILRTFASFFLFCENVLNQSSFFEGKQETVLNMSKDVLNDFGGKGFRGSSLFALAILVSAYYLLYHFFSSRRNFSKVFLHYLAVVVLFGFWFGSVSTSTGTTSGSTFLIQSTNAIAKGVQSTFTTSANLGTEGSKDGEVYQSPIFDATVKQTFNFVNSGSLDGKMENGKKLDESKLLEKPKLSKKEKAKFEDERSTYIKNNEKDNPYFAQDGAKTMEKAFGVGVGVVNLAVLAVPVTYINIMLNVIQIIVDLLILVFPIIALVSFFPRCQMMMFKFFKSLIGILFLPVVFGIFLSVLFWVNKLIDQTFLGLMDKVSSSLLMVMSGGVFLLGTLIVTALVKIILYRKIWKSRYKILSFFSDGQVQQPSFESKMNEKTKETVERTGEIGVGAVKAGIGASTGNLALAADGASHLMPKHDKALNLAKDHFIDDNGQFAGVKTGLNSLLNRSTQEEQQPFKDDMLPEEEIAEVEEPTNVDNEELEEIEDKALTDEVDNFEDSTDDEMDNSLEEFDVPVLDENVSDFDTDTSLADENNIELEPIIENELDSLDSSVESSENDREEPIQELDEQEIADNLNVRVDNFDELAFAREERAFFDGGEDSELITNNNDSLNNVYSFYQTEENFNNLEQTEEQFFGSVNTEEYNFDVVEG
>NZ_CP022712.1|WP_065535846.1|1404146_1405958_-|group-II-intron-reverse-transcriptase/maturase
MSTELRYYEYYNMQETFDWLYQRSLENRTKGINLYDIIISERNILLAYRIIKSNTGSKTAGVDNQTISDYKMKNKAQFIREIRESLGDYKPSMVKRVEIPKPNGKTRPLGIPTMRDRLIQQMFKQVLEPICEAQFYKHSYGFRQNRSTEHAIARCNFVAYACKCHYVVDVDIEGFFDNVSHSKMIKQLYTIGVKDRRVLAIISKMLKAPIKGIGSLDKGTPQGAILSPLLSNVVLNDLDWWIVNQWETFQSRYPYKDNAYMYSALKKTKLKEMHIVRYADDFKIFTNTPKSAIKIFHAVKGYLRNQLSLDISKEKSKITNLRKRYSEFLGFEIKVEKQRKGKYVSISRVSRKVKKKIKKDVRQRVKRIQRYPTFENIKNYNLFVKGIQNYYQKATRVNLDFSDIYYSCLPALFNRLKFIGKYEIPRSPPLVYKKIYSLNHRTFRVNGEYLYPIECIKWDKAWPFRPTVNNYTEQGRLERIKMLKPKIGSELIKMGQKYSENQSIEFLDNKLSRYSMQNGKCAVTGEFLTSEMAHGHHIVPKEQGGTDDYQNIVIVHEWIHKLIHAKTKQTIEEYFNVLQLNEKQLKKLNKYRKECNLAEIRLK
>NZ_CP022712.1|WP_002393069.1|1419584_1420196_-|hypothetical-protein
MSREVIERNTKVAIAITEKMKKGRNDLKKAKEKIIQLDKQGELTIPFLKTTFEKLSESNEELLKEISRYDYTYVVHEAEMTVKEKAIWEEFFNIKKFYDKELSEFASFKEKYKYFEPKNSEELKKQARLLLEKKGYIVDSPFEGDFERWIGVYARPKDKPTYLDPTDGEEAGLQELYSVDGFKQDFAEWFEGEIVEGKLINMV
>NZ_CP022712.1|WP_002371424.1|1420273_1421557_-|XRE-family-transcriptional-regulator
MRGVDLKRYRKELKLKQIEMCQLLSITKGFYSNLESGKRPITQEMEKKIVEVLHIDGGHASVEAKIDFLRIRFKTLDVRTVIEKLLHMDMNWFTHESRGFYHYTETFSYSSIRIFRNPENVNMGIMLDLSGEGCRQLEEIFEEDNNRSWTEFFRSLYDDDIFGQGILVDTKITRIDIALDELIVKGQENFDLYILKEKMEQGLVDTTFKNFDFSGGFAYENKKMVNKGLSLYFGSRQSPLYFNFYQKDYELARKESVSVEEAREKYEIKNRYEIRLSDEKAFLFVEYFLSSGESLDWLVKEIINQSLTVFDIEEGAKVYCKAWYDVVDKLEGLKLSVQGEKPSIEKTLRWLSNYLAPSLKMIKEIDNLLGTNELMERIDLAELKEKHEEIIEMVCVDAKDLLFTTNQNSSVRSYMEQEFDLEEAYPF
>NZ_CP022712.1|WP_002410060.1|1421877_1422285_-|hypothetical-protein
MFSFEEVILQLENKIALKTLKNWANKIERLTDKKFERKYAKNSKGYTYSFKVFSSNDVESFFKLIDLRSKNIPLDIAISDVFMSEEEKKKKETISITKAEFRENQATVKELIDLVKDVLSDNAEIKKRLKVLEMK
>NZ_CP022712.1|WP_002371426.1|1422294_1422582_-|hypothetical-protein
MKFKSQGQMLSYVKEKEQKIIKEIDRRAEKEGVLDNNRLLDYKSLVTSILDAEAFYDEDRPVEEKKFSTSQEVDKYLETIFKEHMDSAWKEIFGK
>NZ_CP022712.1|WP_002371427.1|1422571_1422850_-|hypothetical-protein
MDSNEIIKHVRERVYVEVKKRYKKPDLDTRIRDILYEQSESYAKLVRFSNGKRIKKLTDPVEFEKFIENKGTKIVEEVIFALNKKEEKESEI
>NZ_CP022712.1|WP_002371428.1|1422868_1424377_-|hypothetical-protein
MVKKLFRYRGRRIRYSSRNLLALYRVLFFMPIFACLGYFVGYKWMYPLYLSNPTDWKIYIVPALIIMGVSIGSIVLITLLVKASIINSGYFSKVEQRQVLARMIIDNGYYTKKQVKGSDGKTKEKIKFPKIYYKSAKNSIFVSFETAGNKFQEKFETIGVFLETAFHADNLNKIDEKGFITYELASDVYNKRIWIKDMQADKGKVQLMKGLYWYFDKDPHLLLGGGTGGGKTFTILSLIYALCRVGEMEICDPKNSDLMALGKLPMFAGKVHTGKIDIVNCLKNAVELMNARFEMMNNSPDYKMGKNYAYYGLKPKFIVIDEFAAFKAELANDYAIDGDVDEYLTQLILKARQAGIFFIVAMQRPDGEFIKTALRDNFMFRMSVGRLSETGILMIFGDENKNKNFKYVEKVDGQKVYGRGYVAQGGSVAREFYSPQVPQDFDFIQEFIKISKELGYEEISKEVQEEVSKKISKHVDKEALAEIDEELEAGQAKLAKLSEKFG
>NZ_CP022712.1|WP_002371429.1|1424377_1424758_-|DUF86-domain-containing-protein
MRDSTAKDLRLLRGTLIYIEDIEQTLNRFGRDYETFYHDRVFFNAISMCLMQIGEYTVGNSGFSEEFKEKNSGKVDWKRLRNMRNMFAHSYSTMNERQIFRMATEYIPMYKEFCRQELARLKKEGR
>NZ_CP022712.1|WP_002393071.1|1424747_1425074_-|nucleotidyltransferase-domain-containing-protein
MVMTMNEIKERVKPVAEKHNVPVVYVFGSYARNEAKETSDIDFAVDITGQSEEAYWNLYGDFFEELKEAVAHDIDLVELETLVETQDKPERRELLATILKEGVKVFER
>NZ_CP022712.1|WP_029645162.1|1425133_1425427_-|hypothetical-protein
MGVKQEKYRRFLERKIRVYSMWQSFSYYSTLYLKLYNETSEYLIQFLLLDDLFFECDEAILNLLDNFLEQLVKAYNNKLHEDFDKGVFFKEYTSKVN
>NZ_CP022712.1|WP_002371434.1|1425846_1426035_+|hypothetical-protein
MLKTIEKACEIDMQSVTIILANNQRLKIEKFQSIIDDKILEFISSNIQYYIPEKSILYFTTS

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
NZ_CP022712_1	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	NZ_CP022712.1	1103061-1103090	0	1.0
NZ_CP022712_1	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	NZ_CP022712.1	2344892-2344921	2	0.933

1. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to position: 1103061-1103090, mismatch: 0, identity: 1.0

gattccgagtgattcacttttagcttgttc	CRISPR spacer
gattccgagtgattcacttttagcttgttc	Protospacer
******************************

2. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to position: 2344892-2344921, mismatch: 2, identity: 0.933

gattccgagtgattcacttttagcttgttc	CRISPR spacer
gattccgagtgattcgcttttagcctgttc	Protospacer
***************.********.*****

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NZ_CP022712_1	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	NZ_CP028837	Enterococcus faecalis strain FC plasmid unnamed2, complete sequence	48974-49003	2	0.933
NZ_CP022712_1	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	NZ_CP042215	Enterococcus faecalis strain L15 plasmid pL15-A, complete sequence	5329-5358	2	0.933
NZ_CP022712_1	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	NZ_CP015884	Enterococcus faecalis strain sorialis plasmid Efsorialis-p1, complete sequence	37424-37453	2	0.933
NZ_CP022712_1	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	NZ_CP046125	Enterococcus casseliflavus strain EC291 plasmid unnamed2, complete sequence	26283-26312	2	0.933
NZ_CP022712_3	3.1\|1418656\|29\|NZ_CP022712\|CRISPRCasFinder	1418656-1418684	29	NC_009620	Sinorhizobium medicae WSM419 plasmid pSMED01, complete sequence	652952-652980	7	0.759
NZ_CP022712_1	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	MN855818	Myoviridae sp. isolate 237, complete genome	9541-9570	8	0.733
NZ_CP022712_1	1.3\|795152\|30\|NZ_CP022712\|CRISPRCasFinder,PILER-CR	795152-795181	30	NZ_CP049038	Pseudohalocynthiibacter aestuariivivens strain RR4-35 plasmid pRR4-35_1, complete sequence	145993-146022	8	0.733

1. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to NZ_CP028837 (Enterococcus faecalis strain FC plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.933

gattccgagtgattcacttttagcttgttc	CRISPR spacer
aattccgagtgattcacttttagcctgttc	Protospacer
.***********************.*****

2. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to NZ_CP042215 (Enterococcus faecalis strain L15 plasmid pL15-A, complete sequence) position: , mismatch: 2, identity: 0.933

gattccgagtgattcacttttagcttgttc	CRISPR spacer
aattccgagtgattcacttttagcctgttc	Protospacer
.***********************.*****

3. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to NZ_CP015884 (Enterococcus faecalis strain sorialis plasmid Efsorialis-p1, complete sequence) position: , mismatch: 2, identity: 0.933

gattccgagtgattcacttttagcttgttc	CRISPR spacer
gattccgagtgattcgcttttagcctgttc	Protospacer
***************.********.*****

4. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to NZ_CP046125 (Enterococcus casseliflavus strain EC291 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.933

gattccgagtgattcacttttagcttgttc	CRISPR spacer
gattcctagtgattcacttttagcctgttc	Protospacer
****** *****************.*****

5. spacer 3.1|1418656|29|NZ_CP022712|CRISPRCasFinder matches to NC_009620 (Sinorhizobium medicae WSM419 plasmid pSMED01, complete sequence) position: , mismatch: 7, identity: 0.759

taggtgtt------ggttctggcgttggacccgga	CRISPR spacer
------ttccgcaaggttctggcgctggacccgga	Protospacer
      **      **********.**********

6. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to MN855818 (Myoviridae sp. isolate 237, complete genome) position: , mismatch: 8, identity: 0.733

gattccgagtgattcacttttagcttgttc	CRISPR spacer
aggtccgagtaaatcacttttagctttagc	Protospacer
.. *******.* *************   *

7. spacer 1.3|795152|30|NZ_CP022712|CRISPRCasFinder,PILER-CR matches to NZ_CP049038 (Pseudohalocynthiibacter aestuariivivens strain RR4-35 plasmid pRR4-35_1, complete sequence) position: , mismatch: 8, identity: 0.733

agagacagcgggaaaactacgatattcatc	CRISPR spacer
aagcagttcgggaaaaccacgatattcatt	Protospacer
*.. *   *********.***********.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

201147 : 218918

Enterococcus_phage(46.15%)

holin,tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002380203.1\|201147_203544_+	translation initiation factor IF-2	A0A2H4UTS4	Bodo_saltans_virus	1.3e-19	24.2
WP_002360497.1\|203568_203919_+	30S ribosome-binding factor RbfA	NA	NA	NA	NA
WP_002393873.1\|204001_204232_+	hypothetical protein	NA	NA	NA	NA
WP_002382232.1\|204291_204777_-	toxin	A0A097BY56	Enterococcus_phage	4.4e-60	70.5
WP_002360496.1\|204811_205294_-	helix-turn-helix domain-containing protein	R9QTP6	Staphylococcus_phage	2.6e-20	47.7
WP_002393201.1\|205690_206446_+	DnaD domain protein	A0A0K0MX39	Streptococcus_phage	8.7e-31	56.0
WP_002365547.1\|206464_207307_+	ATP-binding protein	A0A0P0I3L9	Lactobacillus_phage	6.3e-30	30.7
WP_002363798.1\|207373_207766_+	hypothetical protein	NA	NA	NA	NA
WP_002360491.1\|207785_208193_+	RinA family phage transcriptional activator	NA	NA	NA	NA
WP_002382237.1\|208413_208830_+	hypothetical protein	NA	NA	NA	NA
WP_065536033.1\|208842_209355_+\|tail	phage major tail protein, TP901-1 family	W6LP72	Streptococcus_phage	1.5e-34	49.4
WP_002357848.1\|209387_209747_+	hypothetical protein	A0A0F6N4J9	Staphylococcus_phage	7.6e-09	32.2
WP_002382238.1\|209839_210133_+	hypothetical protein	NA	NA	NA	NA
WP_002393202.1\|210122_213056_+	membrane protein	A0A1U9WR55	Streptococcus_virus	1.1e-09	25.0
WP_002365553.1\|213057_213984_+\|tail	phage tail family protein	C9E2K5	Enterococcus_phage	9.0e-147	78.6
WP_002380208.1\|213996_215454_+	hypothetical protein	C9E2K6	Enterococcus_phage	4.7e-174	47.5
WP_002380209.1\|215486_217256_+	hypothetical protein	A0A097BYA8	Enterococcus_phage	1.7e-141	63.6
WP_002380211.1\|217279_217675_+\|holin	phage holin family protein	F0PIJ6	Enterococcus_phage	1.7e-33	48.9
WP_002393203.1\|217793_218918_+	N-acetylmuramoyl-L-alanine amidase	A0A139ZVY1	Enterococcus_phage	5.4e-77	44.3

DBSCAN-SWA_2

638854 : 647499

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002357276.1\|638854_639427_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	4.1e-25	35.1
WP_002360140.1\|639423_640455_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FGG1	Synechococcus_phage	8.2e-56	44.4
WP_002393350.1\|640456_641896_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	4.7e-49	32.1
WP_002380375.1\|641871_644091_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.8e-146	39.8
WP_002361952.1\|644087_644762_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_002357271.1\|644762_645014_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_002357270.1\|645027_645741_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3ELR0	Synechococcus_phage	4.3e-48	43.0
WP_002380376.1\|645893_647018_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
WP_002360132.1\|647010_647499_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	3.8e-19	42.0

DBSCAN-SWA_3

1068393 : 1117249

Streptococcus_phage(30.0%)

tRNA,holin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002392976.1\|1068393_1069149_-\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
WP_065536083.1\|1069228_1071271_-	penicillin-binding protein	NA	NA	NA	NA
WP_002356656.1\|1071478_1072711_+	virion core protein	NA	NA	NA	NA
WP_002380612.1\|1072814_1073960_+	hypothetical protein	NA	NA	NA	NA
WP_002392975.1\|1073956_1074766_+	TPM domain-containing protein	NA	NA	NA	NA
WP_065536084.1\|1074970_1075732_+	DUF3862 domain-containing protein	A9D9J1	Lactobacillus_prophage	1.6e-19	39.9
WP_002380615.1\|1076092_1076824_-	HAD family hydrolase	NA	NA	NA	NA
WP_002362220.1\|1076971_1077199_-	hypothetical protein	NA	NA	NA	NA
WP_002380616.1\|1077286_1077937_-	diphthine--ammonia ligase	NA	NA	NA	NA
WP_001015311.1\|1078491_1079172_+\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6
WP_002360663.1\|1079585_1079942_-	hypothetical protein	NA	NA	NA	NA
WP_002419204.1\|1079934_1080717_-	ParA family protein	Q8JL10	Natrialba_phage	7.7e-22	33.5
WP_000238804.1\|1081299_1081905_-	recombinase family protein	A0A1V0E035	Clostridioides_phage	1.3e-21	34.2
WP_000653331.1\|1082035_1085008_+\|transposase	Tn3 family transposase	A0A125RQ78	Bacillus_phage	3.6e-197	36.4
WP_002360667.1\|1085446_1085557_-	type I toxin-antitoxin system Fst family toxin	NA	NA	NA	NA
WP_010824125.1\|1085807_1086158_-	hypothetical protein	NA	NA	NA	NA
WP_002370254.1\|1086154_1087483_-	Y-family DNA polymerase	Q6DMX4	Streptococcus_phage	3.7e-93	42.4
WP_002406176.1\|1087911_1088214_-	hypothetical protein	NA	NA	NA	NA
WP_010822384.1\|1088225_1088435_-	hypothetical protein	NA	NA	NA	NA
WP_002406593.1\|1088495_1088720_-	hypothetical protein	NA	NA	NA	NA
WP_025188489.1\|1088713_1089028_-	hypothetical protein	NA	NA	NA	NA
WP_025188285.1\|1089017_1089638_-	recombinase family protein	E5FFF9	Burkholderia_phage	7.2e-15	31.1
WP_002401837.1\|1089840_1090155_-	hypothetical protein	NA	NA	NA	NA
WP_065536086.1\|1090243_1090765_-	hypothetical protein	NA	NA	NA	NA
WP_002401839.1\|1090761_1091091_-	hypothetical protein	NA	NA	NA	NA
WP_065536087.1\|1091104_1091719_-	hypothetical protein	NA	NA	NA	NA
WP_002365997.1\|1092324_1092615_-	hypothetical protein	NA	NA	NA	NA
WP_002365996.1\|1092633_1093044_-	hypothetical protein	NA	NA	NA	NA
WP_002365995.1\|1093060_1093576_-	conjugal transfer protein TraF	NA	NA	NA	NA
WP_010785717.1\|1093981_1095442_-	hypothetical protein	NA	NA	NA	NA
WP_025191506.1\|1095544_1095742_-	hypothetical protein	NA	NA	NA	NA
WP_010830231.1\|1095831_1096491_-	DUF2786 domain-containing protein	NA	NA	NA	NA
WP_065536088.1\|1096707_1097046_-	hypothetical protein	NA	NA	NA	NA
WP_025187534.1\|1097129_1097540_-	hypothetical protein	NA	NA	NA	NA
WP_002383622.1\|1097750_1098479_-	hypothetical protein	B5SP25	Lactococcus_phage	1.2e-64	55.0
WP_065536089.1\|1099129_1100389_-	hypothetical protein	A8ATM0	Listeria_phage	3.6e-90	41.2
WP_002404731.1\|1100388_1101168_-	hypothetical protein	A8ATL9	Listeria_phage	8.5e-13	38.9
WP_033624753.1\|1101398_1101590_-	PcfM protein	NA	NA	NA	NA
WP_002365983.1\|1101574_1101760_-	hypothetical protein	NA	NA	NA	NA
WP_002393537.1\|1102594_1102774_-\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_065536090.1\|1103015_1103600_-	thermonuclease family protein	O64020	Bacillus_phage	2.2e-37	56.6
WP_010710134.1\|1103623_1104040_-	single-stranded DNA-binding protein	A0A1S5S8L6	Streptococcus_phage	9.1e-22	50.5
WP_002369776.1\|1104115_1104364_-	DUF3850 domain-containing protein	A0A096XTA8	Enterococcus_phage	9.5e-19	64.0
WP_002360775.1\|1104376_1104877_-	DnaJ domain-containing protein	NA	NA	NA	NA
WP_001015311.1\|1105079_1105760_+\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6
WP_001808764.1\|1106272_1106455_+	hypothetical protein	NA	NA	NA	NA
WP_001245899.1\|1106461_1106728_+	hypothetical protein	A0A1W6JN36	Lactococcus_phage	2.0e-22	68.2
WP_002365921.1\|1106889_1107666_+	hypothetical protein	A8ATL9	Listeria_phage	2.5e-17	44.6
WP_001036756.1\|1107662_1108997_+	hypothetical protein	A8ATM0	Listeria_phage	1.9e-97	42.0
WP_000615486.1\|1109136_1109613_+	single-stranded DNA-binding protein	A0A1S5PRS2	Streptococcus_phage	8.8e-21	49.5
WP_002365924.1\|1109831_1110074_-\|holin	putative holin-like toxin	NA	NA	NA	NA
WP_001031355.1\|1110548_1110746_+	hypothetical protein	NA	NA	NA	NA
WP_002367766.1\|1110887_1111823_+	hypothetical protein	NA	NA	NA	NA
WP_001209505.1\|1112036_1112480_+	hypothetical protein	NA	NA	NA	NA
WP_000865436.1\|1112469_1113333_+	DNA/RNA non-specific endonuclease	NA	NA	NA	NA
WP_002383787.1\|1113456_1114770_+	hypothetical protein	V9QKK6	Oenococcus_phage	4.4e-14	24.8
WP_000406546.1\|1115151_1115793_+	hypothetical protein	NA	NA	NA	NA
WP_065536091.1\|1115917_1117249_+\|transposase	IS1182 family transposase	A0A1X9I5T2	Streptococcus_phage	4.8e-117	49.9

DBSCAN-SWA_4

2065658 : 2073319

Listeria_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065535857.1\|2065658_2066237_-	thermonuclease family protein	O64020	Bacillus_phage	1.1e-36	55.1
WP_065535855.1\|2066414_2066867_-	single-stranded DNA-binding protein	A0A097PAQ3	Streptococcus_pyogenes_phage	3.5e-43	62.0
WP_080476170.1\|2066932_2067427_-	PcfR	NA	NA	NA	NA
WP_002360849.1\|2067481_2067712_+	hypothetical protein	NA	NA	NA	NA
WP_002360847.1\|2068277_2068463_+	hypothetical protein	NA	NA	NA	NA
WP_025191432.1\|2068447_2068639_+	PcfM protein	NA	NA	NA	NA
WP_002360842.1\|2068662_2069253_+	hypothetical protein	A0A1B0XUG6	Freshwater_phage	2.1e-08	38.8
WP_065535854.1\|2069357_2070131_+	hypothetical protein	A8ATL9	Listeria_phage	2.3e-18	49.5
WP_065535853.1\|2070130_2071474_+	hypothetical protein	A8ATM0	Listeria_phage	1.7e-98	41.4
WP_065535852.1\|2071660_2073319_-	hypothetical protein	A0A2H4IZ88	uncultured_Caudovirales_phage	8.1e-05	38.6

DBSCAN-SWA_5

2255685 : 2265425

Streptococcus_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002380777.1\|2255685_2256324_+	dTMP kinase	M1PSC7	Streptococcus_phage	2.1e-54	53.8
WP_002356367.1\|2256343_2256673_+	hypothetical protein	NA	NA	NA	NA
WP_002384059.1\|2256674_2257625_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	6.2e-34	33.0
WP_002356371.1\|2257741_2258581_+	stage 0 sporulation family protein	NA	NA	NA	NA
WP_002356372.1\|2258573_2258921_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	8.1e-16	36.7
WP_002359438.1\|2259032_2259905_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.1e-80	57.2
WP_002356375.1\|2259919_2260582_+	ATP-binding cassette domain-containing protein	G3M9Y6	Bacillus_virus	6.7e-19	31.1
WP_002380776.1\|2260565_2261324_+	iron export ABC transporter permease subunit FetB	NA	NA	NA	NA
WP_002380775.1\|2261449_2262568_+	DNA polymerase IV	NA	NA	NA	NA
WP_002356379.1\|2262612_2263209_-	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A0C5K925	Enterococcus_phage	6.0e-51	56.4
WP_002392852.1\|2263241_2265425_-	anaerobic ribonucleoside-triphosphate reductase	A0A0C5KKX3	Enterococcus_phage	8.9e-286	66.6

DBSCAN-SWA_6

2277475 : 2334038

Streptococcus_phage(45.45%)

bacteriocin,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_065536091.1\|2277475_2278807_+\|transposase	IS1182 family transposase	A0A1X9I5T2	Streptococcus_phage	4.8e-117	49.9
WP_002385691.1\|2279422_2280211_+	O-methyltransferase	NA	NA	NA	NA
WP_002392855.1\|2280451_2281015_+	peroxiredoxin	NA	NA	NA	NA
WP_002362507.1\|2281111_2282794_+	FAD-dependent oxidoreductase	G3MA85	Bacillus_virus	8.1e-53	37.8
WP_002380740.1\|2282893_2283484_-	hypothetical protein	NA	NA	NA	NA
WP_010774685.1\|2283604_2284138_-	3'-5' exonuclease	M1PFD8	Streptococcus_phage	1.1e-22	36.5
WP_002365059.1\|2284171_2284927_-	exodeoxyribonuclease III	E3T4M6	Cafeteria_roenbergensis_virus	2.7e-56	46.7
WP_002380738.1\|2285133_2286048_+	Gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
WP_002356404.1\|2286119_2287022_+	UDP-N-acetylmuramate dehydrogenase	NA	NA	NA	NA
WP_065535911.1\|2288830_2289469_-	CBS domain-containing protein	NA	NA	NA	NA
WP_002356408.1\|2289754_2289907_+	50S ribosomal protein L33	NA	NA	NA	NA
WP_002356409.1\|2289927_2290098_+	preprotein translocase subunit SecE	NA	NA	NA	NA
WP_002384070.1\|2290222_2290768_+	transcription termination/antitermination protein NusG	G3MAW2	Bacillus_virus	1.2e-10	31.3
WP_002380736.1\|2290878_2291766_+	alpha/beta hydrolase	NA	NA	NA	NA
WP_002372307.1\|2291858_2292581_-	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
WP_065535912.1\|2292658_2294287_+	peptide ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_065535913.1\|2294300_2295404_+	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
WP_002362525.1\|2295400_2296246_+	peptidase	NA	NA	NA	NA
WP_002380735.1\|2296310_2297183_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha	NA	NA	NA	NA
WP_002414070.1\|2297205_2297874_-	L-serine ammonia-lyase, iron-sulfur-dependent, subunit beta	NA	NA	NA	NA
WP_002380734.1\|2298249_2299746_+	Lsa family ABC-F type ribosomal protection protein	Q6DMX7	Streptococcus_phage	1.5e-29	26.8
WP_002356424.1\|2299868_2300291_+	50S ribosomal protein L11	NA	NA	NA	NA
WP_002356425.1\|2300402_2301092_+	50S ribosomal protein L1	NA	NA	NA	NA
WP_002356426.1\|2301414_2301915_+	50S ribosomal protein L10	NA	NA	NA	NA
WP_002356427.1\|2301977_2302346_+	50S ribosomal protein L7/L12	NA	NA	NA	NA
WP_001015311.1\|2302853_2303534_+\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6
WP_065535914.1\|2303575_2303806_+	hypothetical protein	NA	NA	NA	NA
WP_065535915.1\|2303798_2304029_+	type III secretion system protein PrgM	NA	NA	NA	NA
WP_065535916.1\|2304052_2304367_+	hypothetical protein	NA	NA	NA	NA
WP_157108314.1\|2304370_2304508_+	hypothetical protein	NA	NA	NA	NA
WP_065535917.1\|2304532_2304853_+	hypothetical protein	NA	NA	NA	NA
WP_065535918.1\|2304923_2305145_+	hypothetical protein	NA	NA	NA	NA
WP_010711009.1\|2305137_2305410_+	type II toxin-antitoxin system RelE/ParE family toxin	X2KQ37	Campylobacter_phage	3.1e-07	38.6
WP_065535919.1\|2305590_2306076_+	DUF3801 domain-containing protein	NA	NA	NA	NA
WP_065535920.1\|2306075_2307887_+	type IV secretory system conjugative DNA transfer family protein	NA	NA	NA	NA
WP_065535921.1\|2308046_2308799_+	Fic family protein	NA	NA	NA	NA
WP_065535922.1\|2308903_2309467_+	hypothetical protein	NA	NA	NA	NA
WP_065535923.1\|2309505_2309979_+	single-stranded DNA-binding protein	A0A097PAQ3	Streptococcus_pyogenes_phage	5.6e-44	60.5
WP_065535924.1\|2310090_2310381_+	hypothetical protein	NA	NA	NA	NA
WP_157108315.1\|2310777_2315328_+	DUF3991 domain-containing protein	NA	NA	NA	NA
WP_065535925.1\|2315386_2315689_+	hypothetical protein	NA	NA	NA	NA
WP_080476186.1\|2316033_2316351_+	plasmid mobilization relaxosome protein MobC	NA	NA	NA	NA
WP_001015311.1\|2316404_2317085_+\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6
WP_065535928.1\|2320335_2320530_-	hypothetical protein	NA	NA	NA	NA
WP_065535929.1\|2320523_2320811_-	hypothetical protein	NA	NA	NA	NA
WP_157662389.1\|2321857_2322007_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_065535931.1\|2322437_2322974_-	Asp23/Gls24 family envelope stress response protein	NA	NA	NA	NA
WP_065535932.1\|2323006_2323195_-	DUF2273 domain-containing protein	NA	NA	NA	NA
WP_065535933.1\|2323211_2323778_-	alkaline shock response membrane anchor protein AmaP	NA	NA	NA	NA
WP_065535934.1\|2325176_2326211_-	YdcF family protein	NA	NA	NA	NA
WP_065535935.1\|2327621_2328821_-	FtsX-like permease family protein	NA	NA	NA	NA
WP_065535936.1\|2328817_2329501_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.5e-39	39.6
WP_065535937.1\|2329497_2330715_-	efflux RND transporter periplasmic adaptor subunit	NA	NA	NA	NA
WP_065535938.1\|2330707_2331196_-	hypothetical protein	NA	NA	NA	NA
WP_065535939.1\|2332578_2333004_-	hypothetical protein	NA	NA	NA	NA
WP_065535940.1\|2332993_2333266_-	hypothetical protein	NA	NA	NA	NA
WP_065535941.1\|2333266_2333536_-	DUF2089 family protein	NA	NA	NA	NA
WP_065535942.1\|2333752_2333884_-\|bacteriocin	enterocin L50 family leaderless bacteriocin	NA	NA	NA	NA
WP_061101451.1\|2333903_2334038_-\|bacteriocin	enterocin L50 family leaderless bacteriocin	NA	NA	NA	NA

DBSCAN-SWA_7

2365514 : 2377327

Streptococcus_phage(80.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001015311.1\|2365514_2366195_+\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6
WP_080476190.1\|2369595_2369871_-\|transposase	IS3 family transposase	A0A2I6AZV9	Macacine_betaherpesvirus	1.1e-07	47.1
WP_080476220.1\|2370244_2370361_-\|transposase	IS3 family transposase	NA	NA	NA	NA
WP_157779255.1\|2370444_2370624_-	hypothetical protein	NA	NA	NA	NA
WP_080476191.1\|2370712_2370883_-	hypothetical protein	NA	NA	NA	NA
WP_065535968.1\|2371687_2372890_+	YSIRK-targeted surface antigen transcriptional regulator	NA	NA	NA	NA
WP_001015311.1\|2373898_2374579_-\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6
WP_001015311.1\|2375397_2376078_+\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6
WP_001015311.1\|2376646_2377327_+\|transposase	IS6-like element IS1216 family transposase	A0A1X9I6C6	Streptococcus_phage	1.5e-127	99.6

DBSCAN-SWA_8

2794522 : 2802435

Planktothrix_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_002364714.1\|2794522_2795575_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.0e-17	30.1
WP_002355795.1\|2795574_2796531_+	ATP-binding cassette domain-containing protein	A0A1J0FA64	Only_Syngen_Nebraska_virus	3.2e-06	23.9
WP_002363279.1\|2796571_2797642_+	helix-turn-helix domain-containing protein	A0A288TXV8	Enterococcus_phage	1.7e-88	48.7
WP_002355797.1\|2798039_2798561_+	translation initiation factor IF-3	A0A2L0UZ54	Agrobacterium_phage	3.0e-14	33.3
WP_002355798.1\|2798674_2798875_+	50S ribosomal protein L35	NA	NA	NA	NA
WP_002355799.1\|2798935_2799295_+	50S ribosomal protein L20	NA	NA	NA	NA
WP_162288125.1\|2799340_2799721_-	hypothetical protein	NA	NA	NA	NA
WP_002361363.1\|2799788_2800148_+	DUF1304 domain-containing protein	NA	NA	NA	NA
WP_002368164.1\|2800215_2800710_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_002361365.1\|2800727_2801243_+	GrpB family protein	A0A2K5B2B6	Erysipelothrix_phage	7.7e-39	48.8
WP_002380126.1\|2801259_2802435_-	SulP family inorganic anion transporter	A0A2H4J153	uncultured_Caudovirales_phage	3.3e-85	47.7

Anti-CRISPR protein detection

Acr_ID: NZ_CP022712.1|WP_002401839.1|1090761_1091091_-|hypothetical-protein

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Acr_ID: NZ_CP022712.1|WP_065536087.1|1091104_1091719_-|hypothetical-protein

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Acr_ID: NZ_CP022712.1|WP_002401837.1|1089840_1090155_-|hypothetical-protein

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Acr_ID: NZ_CP022712.1|WP_065536086.1|1090243_1090765_-|hypothetical-protein

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Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

NZ_CP022712.1|WP_002401839.1|1090761_1091091_-|hypothetical-protein

1090761_1091091_-

109 aa aa

AcrIIA17

hit_Aca_id	identity	query_coverage	hit_coverage
anti_CRISPR3633\|WP_002401839.1\|AcrIIA17\|II-A\|Verified\|Enterococcus-faecalis	1.0	1	1.0

HTH_49

Identity	Hit_domain_coverage
0.4827586206896552	1.0

1068393-1117249

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP022712_1	Orphan	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	1103061-1103090	0

1. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to NZ_CP022712 position: 1103061-1103090, mismatch: 0

gattccgagtgattcacttttagcttgttc	CRISPR spacer
gattccgagtgattcacttttagcttgttc	Protospacer
******************************

NZ_CP022712.1|WP_065536087.1|1091104_1091719_-|hypothetical-protein

1091104_1091719_-

204 aa aa

AcrIIA16

hit_Aca_id	identity	query_coverage	hit_coverage
anti_CRISPR3632\|WP_025188019.1\|AcrIIA16\|II-A\|Verified\|Enterococcus-faecalis	0.9901960784313726	1	1.0

HTH_49

Identity	Hit_domain_coverage
NA	NA

1068393-1117249

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP022712_1	Orphan	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	1103061-1103090	0

1. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to NZ_CP022712 position: 1103061-1103090, mismatch: 0

gattccgagtgattcacttttagcttgttc	CRISPR spacer
gattccgagtgattcacttttagcttgttc	Protospacer
******************************

NZ_CP022712.1|WP_002401837.1|1089840_1090155_-|hypothetical-protein

1089840_1090155_-

104 aa aa

HTH_49

Identity	Hit_domain_coverage
0.4827586206896552	1.0

1068393-1117249

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP022712_1	Orphan	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	1103061-1103090	0

1. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to NZ_CP022712 position: 1103061-1103090, mismatch: 0

gattccgagtgattcacttttagcttgttc	CRISPR spacer
gattccgagtgattcacttttagcttgttc	Protospacer
******************************

NZ_CP022712.1|WP_065536086.1|1090243_1090765_-|hypothetical-protein

1090243_1090765_-

173 aa aa

HTH_49

Identity	Hit_domain_coverage
0.4827586206896552	1.0

1068393-1117249

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
NZ_CP022712_1	Orphan	1.1\|795020\|30\|NZ_CP022712\|CRISPRCasFinder	795020-795049	30	1103061-1103090	0

1. spacer 1.1|795020|30|NZ_CP022712|CRISPRCasFinder matches to NZ_CP022712 position: 1103061-1103090, mismatch: 0

gattccgagtgattcacttttagcttgttc	CRISPR spacer
gattccgagtgattcacttttagcttgttc	Protospacer
******************************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NZ_CP022712

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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