CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP014064	Staphylococcus aureus strain FDAARGOS_159 chromosome, complete genome	8 crisprs	DEDDh,DinG,cas3,csa3,RT,WYL	9	2	12	2
CP014063	Staphylococcus aureus strain FDAARGOS_159 plasmid unnamed, complete sequence	0 crisprs	csa3	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP014064_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP014064_1

31264-31345

Orphan

Consensus_repeat	Method
CCCCAACTTGCATTGTCTGTAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP014064_1

>merge|CP014064|1|31264-31345|CRISPRCasFinder
CCCCAACTTGCATTGTCTGTAGAAATTGAGAATCCAATTTCTCTTTGTTGGGGCCCATCCCCAACTTGCATTGCCTGTAGAA

>CP014064|1|1|31264-31345|CRISPRCasFinder
CCCCAACTTGCATTGTCTGTAGAA	ATTGAGAATCCAATTTCTCTTTGTTGGGGCCCAT
CCCCAACTTGCATTGCCTGTAGAA

Protein	Signature genes	Signature genes Name	Protein_function
CP014064.2\|AMG40578.1\|38253_39561_+\|Fe-S-cluster-assembly-protein-SufD	unknown	unknown	gnl\|CDD\|223791
CP014064.2\|AMG40565.1\|29208_29565_+\|arsenate-reductase-family-protein	unknown	unknown	gnl\|CDD\|239334
CP014064.2\|AMG40577.1\|37394_38156_+\|Fe-S-cluster-assembly-ATPase-SufC	unknown	unknown	gnl\|CDD\|223473
CP014064.2\|AMG40571.1\|32335_32632_+\|thioredoxin	unknown	unknown	gnl\|CDD\|239245
CP014064.2\|AMG40576.1\|36215_37067_-\|DUF368-domain-containing-protein	unknown	unknown	gnl\|CDD\|224946
CP014064.2\|AMG40559.2\|24387_24948_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
CP014064.2\|AMG40560.1\|25792_26287_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|372596
CP014064.2\|AMG40569.1\|31633_31747_+\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG40566.1\|29722_30103_+\|glycine-cleavage-system-protein-H	unknown	unknown	gnl\|CDD\|234918
CP014064.2\|AMG40567.1\|30166_30280_+\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG40562.1\|27255_27972_+\|3-dehydroquinase	unknown	unknown	gnl\|CDD\|184156
CP014064.2\|AMG40574.1\|34612_35434_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
CP014064.2\|AMG40561.1\|26685_27108_-\|organic-hydroperoxide-reductase-OsmC/OhrA	unknown	unknown	gnl\|CDD\|274649
CP014064.2\|AMG40575.1\|35787_35982_+\|CsbD-family-protein	unknown	unknown	gnl\|CDD\|225777
CP014064.2\|AMG40572.1\|32881_33907_+\|methionine-import-ATP-binding-protein-MetN-2	unknown	unknown	gnl\|CDD\|224058
CP014064.2\|AMG40568.1\|30281_31160_+\|DUF1963-domain-containing-protein	unknown	unknown	gnl\|CDD\|226395
CP014064.2\|AMG40563.1\|28054_28594_+\|nitroreductase	unknown	unknown	gnl\|CDD\|380312
CP014064.2\|AMG40570.1\|31956_32343_+\|topiosmerase	unknown	unknown	gnl\|CDD\|224572
CP014064.2\|AMG40573.1\|33899_34595_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224922
CP014064.2\|AMG40564.1\|28744_29065_-\|thioredoxin	unknown	unknown	gnl\|CDD\|239245

Protein	Function_ID	Function_description	E-value
CP014064.2\|AMG40578.1\|38253_39561_+\|Fe-S-cluster-assembly-protein-SufD	gnl\|CDD\|223791	COG0719, SufB, Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones].	3.36148e-135
CP014064.2\|AMG40565.1\|29208_29565_+\|arsenate-reductase-family-protein	gnl\|CDD\|239334	cd03036, ArsC_like, Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.	1.06191e-56
CP014064.2\|AMG40577.1\|37394_38156_+\|Fe-S-cluster-assembly-ATPase-SufC	gnl\|CDD\|223473	COG0396, sufC, Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones].	1.29081e-150
CP014064.2\|AMG40576.1\|36215_37067_-\|DUF368-domain-containing-protein	gnl\|CDD\|224946	COG2035, COG2035, Predicted membrane protein [Function unknown].	7.67366e-77
CP014064.2\|AMG40559.2\|24387_24948_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	7.9429e-44
CP014064.2\|AMG40560.1\|25792_26287_-\|N-acetyltransferase	gnl\|CDD\|372596	pfam13420, Acetyltransf_4, Acetyltransferase (GNAT) domain.	2.53639e-47
CP014064.2\|AMG40568.1\|30281_31160_+\|DUF1963-domain-containing-protein	gnl\|CDD\|226395	COG3878, COG3878, Uncharacterized protein conserved in bacteria [Function unknown].	3.13065e-77
CP014064.2\|AMG40570.1\|31956_32343_+\|topiosmerase	gnl\|CDD\|224572	COG1658, COG1658, Small primase-like proteins (Toprim domain) [DNA replication, recombination, and repair].	2.45102e-36
CP014064.2\|AMG40575.1\|35787_35982_+\|CsbD-family-protein	gnl\|CDD\|225777	COG3237, COG3237, Uncharacterized protein conserved in bacteria [Function unknown].	5.95583e-07
CP014064.2\|AMG40566.1\|29722_30103_+\|glycine-cleavage-system-protein-H	gnl\|CDD\|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	9.01516e-70
CP014064.2\|AMG40562.1\|27255_27972_+\|3-dehydroquinase	gnl\|CDD\|184156	PRK13575, PRK13575, type I 3-dehydroquinate dehydratase.	3.2619e-146
CP014064.2\|AMG40574.1\|34612_35434_+\|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	1.02861e-112
CP014064.2\|AMG40561.1\|26685_27108_-\|organic-hydroperoxide-reductase-OsmC/OhrA	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	5.58225e-61
CP014064.2\|AMG40571.1\|32335_32632_+\|thioredoxin	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	7.01368e-14
CP014064.2\|AMG40563.1\|28054_28594_+\|nitroreductase	gnl\|CDD\|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	5.18259e-50
CP014064.2\|AMG40572.1\|32881_33907_+\|methionine-import-ATP-binding-protein-MetN-2	gnl\|CDD\|224058	COG1135, AbcC, ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism].	2.03316e-170
CP014064.2\|AMG40573.1\|33899_34595_+\|ABC-transporter-permease	gnl\|CDD\|224922	COG2011, AbcD, ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism].	7.66296e-99
CP014064.2\|AMG40564.1\|28744_29065_-\|thioredoxin	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	2.4922e-24

>CP014064.2|AMG40568.1|30281_31160_+|DUF1963-domain-containing-protein
MLNIQDVSHLSKKEQKAYNRFVESVENGNLPVLPCIEMDLKEMQEETLSQSKIGGMPFLKSFKDIPLDENNVPMVLLAQINLNDLPEQQELFPVNEGILQFWISSEDQMYGMSENLKGNNINSRLVYIKEPITDLSLENIQVHLKSLDADNEDIPFSGAFSIEFRLSKQTITCTDYKYDEDVLALWNKVNPSFALKSMFGGYDELMEPVCNTFTAKEPFNQLGGYPYFDQIDPRTNDQELKMYDRVLLQIDSTRDGNSSIIWGDLGIANILVKSTDLEAMKFDDYMYSWDCS
>CP014064.2|AMG40567.1|30166_30280_+|hypothetical-protein
MKENLLGTIIWSIATFYYSRMMKIMNLAILKIKIGGS
>CP014064.2|AMG40566.1|29722_30103_+|glycine-cleavage-system-protein-H
MAVPNELKYSKEHEWVKVEGNVATIGITEYAQSELGDIVFVELPETDDEINEGDTFGSVESVKTVSELYAPISGKVVEVNEELEDSPEFVNESPYEKAWMVKVEISDESQLEALLTAEKYSEMIGE
>CP014064.2|AMG40565.1|29208_29565_+|arsenate-reductase-family-protein
MIKFYQYKNCTTCKKAAKFLDEYGVSYEPIDIVQHTPTINEFKTIIANTGVEINKLFNTHGAKYRELDLKNKLQTLSDDEKLELLSSDGMLVKRPLAVMGDKITLGFKEDQYKETWLA
>CP014064.2|AMG40564.1|28744_29065_-|thioredoxin
MQAIKSNESFKSIINSDTPVIVKFEAGWCPDCRAMDLWIDPIVEQYNDYQWYTVNRDELEDVVVENEVMGIPSLLVFKNGDKIAHLHSANAKSPEQVESFLAETFK
>CP014064.2|AMG40563.1|28054_28594_+|nitroreductase
MELQQAIANRRSVKKFKRDMHIDDALLYQAIEKAADAPNHGMREPWRVVYVPKDRLGDMSKDISKFAFPNELDKQQCHYDAVTKLGGMLLLILKTDPRQRQNDENYFAFGAYAQNLMLLLYEAGIGTCWKSPLYIYDPKVRKTLGIKKDEVLAGFLYLTDLEEDMPKAPRKNRNLITLY
>CP014064.2|AMG40562.1|27255_27972_+|3-dehydroquinase
MTHVEVVATIAPQLSIEETLIQKINHRIDAIDVLELRIDQIENVTVDQVAEMITKLKVMQDSFKLLVTYRTKLQGGYGQFINDLYLNLISDLANINGIDMIDIEWQADIDIEKHQRIIKHLQQYNKEVVISHHNFESTPPLDELQFIFFKMQKFNPEYVKLAVMPHNKNDVLNLLQAMSTFSDTMDCKVVGISMSKLGLISRTAQGVFGGALTYGCIGEPQAPGQIDVTDLKAQVTLY
>CP014064.2|AMG40561.1|26685_27108_-|organic-hydroperoxide-reductase-OsmC/OhrA
MAIHYETKATNVGGRKGHVYTDDRALDIDIVPPAQADGKATNPEQLFAAGYASCFNGAFDLILKQNKVRDAHPEVTLTVRLEDDSDSESPKLSVSIDATIKNVISQEEAEKYLQMAHEFCPYSKATQGNINVDLNVNVVD
>CP014064.2|AMG40560.1|25792_26287_-|N-acetyltransferase
MIEIKTLTNNDFNEYKRLVSTVNEEFTQDSHYSQTMTDTLIHDILNQGSPKCIVFGCYENETLIATAALEQIRYVGKEHKSLIKYNFVTNNDKSINSELINFIINYARQNNYESLLTSIVSNNIGAKVFYSALGFDILGFEKNAIKIGNTYFDEHWLFYDLINK
>CP014064.2|AMG40559.2|24387_24948_+|histidine-phosphatase-family-protein
MRHGQTLFNFKGLIQGFGDSPLTELGIAQAQKARSYYETKGINFDLYASSTQERASDTLENVAPNQSYQRFKGLKEWHFGIFEGESVYLFDNLYKPEDLFGDRIVPFKGEARQQVEERIVKTLHDIMSQTKNNALVVSHGTIMGVFLRYCLKLDEALKHNIGNCNILKFEYDNGTFKFVELIDPNL
>CP014064.2|AMG40569.1|31633_31747_+|hypothetical-protein
MLGPRQLAHYCKLTYHQLLCWGPAIIEKFVIGVFSFG
>CP014064.2|AMG40570.1|31956_32343_+|topiosmerase
MAIVNKVIIVEGKSDKKRVQQVIAEPVNIICTHGTMSIDKLDDMIESLYDKQVFVLADSDDEGDRIRNWFKRYLSESEHIFIDKTYCQVANCPKQYLAHVLSKHGFTCKKETPLLPNINNERLVLVNE
>CP014064.2|AMG40571.1|32335_32632_+|thioredoxin
MNNSLDIKDVTTFYEEDKHLIFGYTPTCGTCKVSERMLDIANEILQLPLLKIDLNFYPQFCKDMQIMSTPILLLMNKDKEVKRIYAFKSVTDLLENLK
>CP014064.2|AMG40572.1|32881_33907_+|methionine-import-ATP-binding-protein-MetN-2
MIELKEVVKEYRTKNKEVLAVDHVNLSIRAGSIYGVIGFSGAGKSTLIRMFNHLEAPTSGEVIIDGDHIGQLSKNGLRAKRQKVSMIFQHFNLLWSRTVLKNIMFPLEIAGVPRRRAKQKALELVELVGLKGREKAYPSELSGGQKQRVGIARALANDPTVLLCDEATSALDPQTTDEILDLLLKIREQQNLTIVLITHEMHVIRRICDEVAVMESGKVIEHGPVTQVFENPQHTVTKRFVKEDLNDDFETSLTELEPLEKDAYIVRLVFAGSTTTEPIVSSLSTAYDIKINILEANIKNTKNGTVGFLVLHIPYISSVDFGKFEKELIERQVKMEVLRHG
>CP014064.2|AMG40573.1|33899_34595_+|ABC-transporter-permease
MGKSFSEIINEMITMPNIQWPEVWTAIVETLYMTVVSTIFAFILGLILGVLLFLSAKGKSIGARLFYSIVSFIVNLFRAIPFIILILLLIPFTSLILGTISGPTGALPALIIGAAPFYARLVEIAFKEIDKGVIEAAWSMGANTWIVIRKVLLPEAMPALVSGITVTAIALVGSTAVAGVIGAGGLGNLAYLTGFTRNQNDVILVSTVFILIIVFIIQFIGDWLTNKLDKR
>CP014064.2|AMG40574.1|34612_35434_+|MetQ/NlpA-family-ABC-transporter-substrate-binding-protein
MKKLFGLILVLTFAVVLAACGNGNKSGSDDKKITVGASPAPHAEILEKAKPLLEKKGYDLDIKTINDYTTPNKLLDKGEIDANYFQHTPYLNTEKKDKGYKIVSAGDVHLEPMAVYSKKYKSLKELPKGATVYVSNNPAEQGRFLKFFVDAGLIKIKKGVKIEDAKFSDITENKKDIKFNNKQSAEFLPKIYQNEDADAVIINSNFAIEQKLNPKKDSIAVESAKDNPYANLIAVKEGHQDDKKIKALIEVLQSKDIQDFINEKYNGAVIPAK
>CP014064.2|AMG40575.1|35787_35982_+|CsbD-family-protein
MADESKFEQAKGNVKETVGNVTDNKNLENEGKEDKASGKAKEFVENAKEKATDFIDKVKGNKGE
>CP014064.2|AMG40576.1|36215_37067_-|DUF368-domain-containing-protein
MQQFKWINILKGFAMGTSDLVPGVSGGTIALLLGIYNQFIASISGIFSRRFWPSFTFLIPIIIGMLLAMGSLSNLFNYLLSQHHIPTMFFFGGLIIGIVPYLLKISNYKTSFTTKHYMMVIAGIAILIVITLMNNGDKHAGETLTLSTGLIIKYFIAGMCASSAMLLPGISGSFMLLVFGVYGTVMLAISEVVKLNFTGLPILLAVGFGVLAGFIISSKIIQYFLTHHKLMTFALIIGFVVGSLFAVFPGLPTNIVMWFVSLVVFIIGFIVSLTLGRITAENE
>CP014064.2|AMG40577.1|37394_38156_+|Fe-S-cluster-assembly-ATPase-SufC
MASTLEIKDLHVSIEDKEILKGVNLTINTDEIHAIMGPNGTGKSTLSSAIMGHPSYEVTKGEVLLDGVNILELEVDERAKAGLFLAMQYPSEITGVTNADFMRSAINAKREEGQEINLMQFIKKLDKNMDFLDIDKDMAQRYLNEGFSGGEKKRNEILQLMMLEPKFAILDEIDSGLDIDALKVVSKGINQMRGENFGALMITHYQRLLNYITPDKVHVMYAGKVVKSGGPELAKRLEEEGYEWVKEEFGSAE
>CP014064.2|AMG40578.1|38253_39561_+|Fe-S-cluster-assembly-protein-SufD
MTTDILNISEEQLVDYSKAHNEPSWMTELRKKALKLTETLEMPKPDKTKLRKWDFDSFKQHDVKGDVYQSLSQLPESVREIIDVDHSKNLVIQHNNTIAYTQVDDNASKDGVIVEGLADALMNHSDLVQKHFMKDAVTVDEHRITALHTALVNGGVFVYVPKNVVVEHPVQYVVLHDDKNASFYNHVIIVTEESAEVTYVENYLSNASGEGNQLNIISEVIAGANSNITYGSVDYMDKGFTGHIIRRGITEADASINWALGLMNEGSQIIDNTTNLFGDRSTSSLKSVVVGTGEQKINLTSKIVQYGKETDGYILKHGVMKEHASSVFNGIGYIKHGGTKSIANQESRVLMLSEHARGDANPILLIDEDDVQAGHAASVGRVDPDQLYYLMSRGISQREAERLVIHGFLDPVVRELPIEDVKRQLREVIERKVSK

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Crispr_ID: CP014064_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP014064_2

1248229-1248310

Orphan

Consensus_repeat	Method
GGCCCCCACCCCAACTTACATTGT	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of CP014064_2

>merge|CP014064|2|1248229-1248310|CRISPRCasFinder
GGCCCCCACCCCAACTTACATTGTTTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCCACCCCAACTTGCATTGT

>CP014064|2|2|1248229-1248310|CRISPRCasFinder
GGCCCCCACCCCAACTTACATTGT	TTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGG
GGCCCCCACCCCAACTTGCATTGT

Protein	Signature genes	Signature genes Name	Protein_function
CP014064.2\|AMG41752.1\|1245293_1246349_-\|bi-component-leukocidin-LukGH-subunit-H	unknown	unknown	gnl\|CDD\|369625
CP014064.2\|AMG41763.1\|1257981_1258125_+\|cyclic-lactone-autoinducer-peptide	unknown	unknown	gnl\|CDD\|129030
CP014064.2\|AMG41760.1\|1255660_1256446_+\|carbon-nitrogen-family-hydrolase	unknown	unknown	gnl\|CDD\|143607
CP014064.2\|AMG41745.1\|1239811_1240744_+\|ATP-dependent-helicase	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235735
CP014064.2\|AMG41746.1\|1240749_1241091_+\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG41757.1\|1252449_1253193_+\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
CP014064.2\|AMG41743.1\|1238946_1239120_-\|transcriptional-regulator	unknown	unknown	unknown
CP014064.2\|AMG41749.1\|1242099_1243137_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
CP014064.2\|AMG41753.1\|1246784_1248008_+\|succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl\|CDD\|181490
CP014064.2\|AMG41756.1\|1251990_1252275_-\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
CP014064.2\|AMG41758.1\|1253217_1254477_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236768
CP014064.2\|AMG41755.1\|1250298_1251915_-\|molecular-chaperone-GroEL	unknown	unknown	gnl\|CDD\|234573
CP014064.2\|AMG41759.1\|1254673_1255300_+\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|226090
CP014064.2\|AMG41754.1\|1248451_1249759_+\|TrkH-family-potassium-uptake-protein	unknown	unknown	gnl\|CDD\|273349
CP014064.2\|AMG41744.1\|1239082_1239796_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225484
CP014064.2\|AMG41761.1\|1257045_1257180_-\|delta-lysin-family-phenol-soluble-modulin	unknown	unknown	gnl\|CDD\|173213
CP014064.2\|AMG41751.1\|1244255_1245272_-\|bi-component-leukocidin-LukGH-subunit-G	unknown	unknown	gnl\|CDD\|369625
CP014064.2\|AMG41747.1\|1241294_1241477_+\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG41762.1\|1257415_1257979_+\|accessory-gene-regulator-AgrB	unknown	unknown	gnl\|CDD\|226899
CP014064.2\|AMG41748.1\|1241576_1242041_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236154

Protein	Function_ID	Function_description	E-value
CP014064.2\|AMG41752.1\|1245293_1246349_-\|bi-component-leukocidin-LukGH-subunit-H	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.84035e-77
CP014064.2\|AMG41763.1\|1257981_1258125_+\|cyclic-lactone-autoinducer-peptide	gnl\|CDD\|129030	smart00794, AgrD, Staphylococcal AgrD protein. This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr.	3.13559e-15
CP014064.2\|AMG41762.1\|1257415_1257979_+\|accessory-gene-regulator-AgrB	gnl\|CDD\|226899	COG4512, AgrB, Membrane protein putatively involved in post-translational modification of the autoinducing quorum-sensing peptide [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Transcription].	6.65966e-71
CP014064.2\|AMG41760.1\|1255660_1256446_+\|carbon-nitrogen-family-hydrolase	gnl\|CDD\|143607	cd07583, nitrilase_5, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	5.69545e-126
CP014064.2\|AMG41745.1\|1239811_1240744_+\|ATP-dependent-helicase	gnl\|CDD\|235735	PRK06195, PRK06195, DNA polymerase III subunit epsilon; Validated.	1.68456e-42
CP014064.2\|AMG41753.1\|1246784_1248008_+\|succinyl-diaminopimelate-desuccinylase	gnl\|CDD\|181490	PRK08588, PRK08588, succinyl-diaminopimelate desuccinylase; Reviewed.	0
CP014064.2\|AMG41757.1\|1252449_1253193_+\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.67124e-11
CP014064.2\|AMG41755.1\|1250298_1251915_-\|molecular-chaperone-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
CP014064.2\|AMG41748.1\|1241576_1242041_+\|hypothetical-protein	gnl\|CDD\|236154	PRK08119, PRK08119, flagellar motor switch protein; Validated.	0.00756653
CP014064.2\|AMG41758.1\|1253217_1254477_-\|hypothetical-protein	gnl\|CDD\|236768	PRK10819, PRK10819, transport protein TonB; Provisional.	1.10653e-08
CP014064.2\|AMG41759.1\|1254673_1255300_+\|nitroreductase-family-protein	gnl\|CDD\|226090	COG3560, FMR2, Predicted oxidoreductase related to nitroreductase [General function prediction only].	8.42197e-117
CP014064.2\|AMG41754.1\|1248451_1249759_+\|TrkH-family-potassium-uptake-protein	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	7.96864e-82
CP014064.2\|AMG41744.1\|1239082_1239796_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|225484	COG2932, COG2932, Predicted transcriptional regulator [Transcription].	5.17989e-24
CP014064.2\|AMG41751.1\|1244255_1245272_-\|bi-component-leukocidin-LukGH-subunit-G	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.05827e-99
CP014064.2\|AMG41761.1\|1257045_1257180_-\|delta-lysin-family-phenol-soluble-modulin	gnl\|CDD\|173213	PRK14752, PRK14752, delta-lysin family phenol-soluble modulin.	8.25732e-15
CP014064.2\|AMG41756.1\|1251990_1252275_-\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	5.94304e-45
CP014064.2\|AMG41749.1\|1242099_1243137_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	2.40962e-25

>CP014064.2|AMG41753.1|1246784_1248008_+|succinyl-diaminopimelate-desuccinylase
MTTFSEKEKIQLLADIVELQTENNNEIDVCNYLKDLFDKYDIKSEILKVNEHRANIVAEIGNGSPILALSGHMDVVDAGNQDNWTYPPFQLTEKAGKLYGRGTTDMKGGLMALVITLIELKEQNQLPQGTIRLLATAGEEKEQEGAKLLADKGYLDDVDGLIIAEPTGSGIYYAHKGSMSCKVTATGKAVHSSVPFIGDNAIDTLLEFYNQFKEKYSELKKHDTKHELDVAPMFKSLIGKEISEEDANYASGLTAVCSIINGGKQFNSVPDEASLEFNVRPVPEYDNDFIESFFQNIINDVDSNKLSLDIPSNHRPVTSDKNSKLITTIKDVASSYVEQDEIFVSALVGATDASSFLGDNKDNVDLAIFGPGNPLMAHQIDEYIEKDMYLKYIDIFKEASIQYLKEK
>CP014064.2|AMG41752.1|1245293_1246349_-|bi-component-leukocidin-LukGH-subunit-H
MKNKKRVLIASSLSCAILLLSAATTQANSAHKDSQDQNKKEHVDKSQQKDKRNVTNKDKNSTVPDDIGKNGKITKRTETVYDEKTNILQNLQFDFIDDPTYDKNVLLVKKQGSIHSNLKFESHKEEKNSNWLKYPSEYHVDFQVKRNRKTEILDQLPKNKISTAKVDSTFSYSSGGKFDSTKGIGRTSSNSYSKTISYNQQNYDTIASGKNNNWHVHWSVIANDLKYGGEVKNRNDELLFYRNTRIATVENPELSFASKYRYPALVRSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDILKNRPGIHYAPPILEKNKDGQRLIVTYEVDWKNKTVKVVDKYSDDNKPYKEG
>CP014064.2|AMG41751.1|1244255_1245272_-|bi-component-leukocidin-LukGH-subunit-G
MIKQLYKNITICSLAISTALTVFPATSYAKINSEIKAVSEKNLDGDTKMYTRTATTSDSQKNITQSLQFNFLTEPNYDKETVFIKAKGTIGSGLRILDPNGYWNSTLRWPGSYSVSIQNVDDNNNTNVTDFAPKNQDESREVKYTYGYKTGGDFSINRGGLTGNITKESNYSETISYQQPSYRTLLDQSTSHKGVGWKVEAHLINNMGHDHTRQLTNDSDNRTKSEIFSLTRNGNLWAKDNFTPKDKMPVTVSEGFNPEFLAVMSHDKKDKGKSQFVVHYKRSMDEFKIDWNRHGFWGYWSGENHVDKKEEKLSALYEVDWKTHDVKFVKVLNDNEKK
>CP014064.2|AMG41749.1|1242099_1243137_+|site-specific-integrase
MKTRCYDGKKWQYEFKHEGKRYRKKGFRTKREANSAGLDKLNELRSGFNIDNYITLEEYFENWIKTYKQPVVKENTYRHYRNALQHIQKHKIGKMELSKINRQVYQKFINDYSKEHAKETIRKTNGAIRSALDDALYDGLIFKNPAYKVNYKAGKPTKSEQEKFISVTEYEILKDHVRKKRTRSSLALFIMICTGCRVSGARNIKIEHINQVKNTIFIDERKTNTSPRYISIAKSDMKHIMDVISTFAISYDGYIFKEGGSIINLHAINNALKSACRVNNIPIITSHALRHTHCSYLLAKGVSIHYISKRLGHKNIAITTSVYSHLLEEKFNEEDKKTTKILESM
>CP014064.2|AMG41748.1|1241576_1242041_+|hypothetical-protein
MKRLLGLLLVSTLVLSACGNDENQEESKKEVKSKEKKIEKEKENKSKKDKEKEVATQQQPDNQTVEQPQSQEQSVQQPQQQIPQNSVPQQNVQVQQNKKQKVDLNNMPPTDFSTEGMSEQAQKQIEELSMQKDYHGLSQREYNDRVSEIINNDN
>CP014064.2|AMG41747.1|1241294_1241477_+|hypothetical-protein
MKITNCKIKRETVIYEVLTSGNQPFTYELPKDLSSHNARKYLEFISQKLDGDKLTKEDSL
>CP014064.2|AMG41746.1|1240749_1241091_+|hypothetical-protein
MIKKIFTKKHVFLVIEDENHNHSDAVFGKSILLSIYVGVNKKTNSKSGKFIYLDRSKRIVRQSDITKIESANENDVDFYNLLKKEKEIVYSKNIVDKYNLANYIIYYEVSTKE
>CP014064.2|AMG41745.1|1239811_1240744_+|ATP-dependent-helicase
MKKYDIAVLDFETMNEHMNSPCEVAVSLIKDLSIVKVYSSYINPPNNRYNLKNAKIHKIPEDVILKAPKYPDIYQEILYLLKESHLIIAHNALFDISVLKNTNNYYDLPVPNFMYVDSINIFRSFHAISSFKLENLCSLYDIDKEKLHSAKFDVLALSKMLISLAKNNQHYSVLKLIHYMPKQYIRFSKYSNSPTKLFDSGFQKIHMKISEINKIEVESVIPILKDKNVVFTGNFDTEKQDLMILTRKKGAYIRSDVTAKTDILVEGVQDDKYKDVNGLVSKQRKAREYVGNGAKIQFLNEEDLINLIKE
>CP014064.2|AMG41744.1|1239082_1239796_+|XRE-family-transcriptional-regulator
MNKERNIIIAKNIRKFLNDSNMSQKKLAELINIKPSTLSDYLNLRSNPSHGVIQRIADVFEVGKSDIDTTYKDDNDITSIYNKLTPPRQENVLNYANEQLEEQNSKGDNVVDINSYKQEKTPVNVNGCVSAGVGERLHDETLFTEMVKGPIPTHDLALKVNGDSMEPMFKDGEIIFVEKTHNIKNGQIGIFIIEEEAYVKKVFVEDDRLTLVSLNKDYDDLHFYRNESVRLIGKVIL
>CP014064.2|AMG41743.1|1238946_1239120_-|transcriptional-regulator
MFLAIIIFLSLFILLTSFFLIIRNFHIIVKFFTKKTYLMLTIRKFRIILGLRKAVTT
>CP014064.2|AMG41754.1|1248451_1249759_+|TrkH-family-potassium-uptake-protein
MNKVHKPLYFYLMLFFSTTIIGALLLYLPFTGKKPISFLDALFIASSAFTVTGLSPVDIGSQFNILGEIVILLLIQIGGLGIVTVTLLTLVFLNRKISMKNRFLIMVTWNIDEPGGVIKLIKHLAIYSLVTELIGMICLCLSFIPKFGIGKGLFLSLFTSVSAFNNAGFALFKNNLIDYSSDPIVIITISILIIFGGIGHFVVIDFINCKKLSKLSLHSKLVLTTTSILIIIGAITFFLLEQFNTMQHMGLVEKIGNSFFQSVTTRTAGFNSIDIASINKSTALMLMLLMFIGGAPLSAAGGIKITTFAVAFIFVLNYIRKENNVSVFNKEISDKHIKLSIVTINISFLFISIITFILSIINPNISLIKLLFEVVSAFGTVGLSMNLTTEYHGITKIIIIFVMLCGKVGLLTLLRTFIPPKSPKNYRYTKGQIYL
>CP014064.2|AMG41755.1|1250298_1251915_-|molecular-chaperone-GroEL
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVAVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQSNRPILIVADEVEGDALTNIVLNRMRGTFTAVAVKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNVYQKVSEIEAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATNEWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
>CP014064.2|AMG41756.1|1251990_1252275_-|co-chaperone-GroES
MLKPIGNRVIIEKKEQEQTTKSGIVLTDSAKEKSNEGVIVAVGTGRLLNDGTRVTPEVKEGDRVVFQQYAGTEVKRDNETYLVLNEEDILAVIE
>CP014064.2|AMG41757.1|1252449_1253193_+|CPBP-family-intramembrane-metalloprotease
MTRLWASLLTVIIYILSQFLPLLIVKKLPFVQYSGIELTKAVIYIQLVLFLIAATTIILINLKIKNPTKLELEVKEPKKYIIPWALLGFALVMIYQMVVSIVLTQIYGGQQVSPNTEKLIIIARKIPIFIFFVSIIGPLLEEYVFRKVIFGELFNAIKGNRIVAFIIATTVSSLIFALAHNDFKFIPVYFGMGVIFSLAYVWTKRLAVPIIIHMLQNGFVVIFQLLNPEALKKATEQANFIYHIFIP
>CP014064.2|AMG41758.1|1253217_1254477_-|hypothetical-protein
MSYHWFKKMLLSTSILILSSSSLGLATHTVEAKDNLNGEKPTTNLNHNITSPSVNSEMNNNETGTPHESNQTGNEGTGSNSRDANPDSNNVKPDSNNQNPSTDSKPDPNNQNPSPNPKPDPDNPKPKPDPKPDPDKPKPNPDPKPDPDKPKPNPNPKPDPDKPKPNPDPKPDPDKPKPNPNPKPDPNKPNPNPSPDPDQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGNSQNPTGNDFVSQRFLALANGAYKYNPYILNQINKLGKDYGEVTDEDIYNIIRKQNFSGNAYLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRSFEPHEKDDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNESQRR
>CP014064.2|AMG41759.1|1254673_1255300_+|nitroreductase-family-protein
MGLFKKDKKAMTFDNAMEERRSIYNLKDSISISDDELESMIAHAVKHVPSSFNSQSTRIVLLLNDNNNKFWDNTKAILKEVMGENRDFEPTEQKIDNFKHSYGTILFYEDQDVVSGLQEQMPNYYDNFAIWSTQTNAMHQFAIWTALATKGIGASLQHYNPLVDEMTSKEFNIPKSWKLIAQMPFGDIREAAGEKTFNPVEDRFVIKK
>CP014064.2|AMG41760.1|1255660_1256446_+|carbon-nitrogen-family-hydrolase
MKVQIYQLPIIFGDSSKNETQITQWFEKNMNAEVDVVVLPEMWNNGYDLEHLNEKADNNLGQSFSFIKHLAEKYKVDIVAGSVSNIRNYQIFNTAFSVNKSGQLINEYDKVHLVPMLREHEFLTAGENVAEPFQLSDGTYVTQLICYDLRFPELLRYPARSGAKIAFYVAQWPMSRLQHWHSLLKARAIENNMFVIGTNSTGFDGNTEYAGHSIVINPNGDLVGELNESADILTVDLNLNEVEQQRENIPVFKSIKLDLYK
>CP014064.2|AMG41761.1|1257045_1257180_-|delta-lysin-family-phenol-soluble-modulin
MSCLILRIFILIKEGVISMAQDIISTIGDLVKWIIDTVNKFTKK
>CP014064.2|AMG41762.1|1257415_1257979_+|accessory-gene-regulator-AgrB
MNYFDNKIDQFATYLQKRNNLDHIQFLQVRLGMQIIVGNFFKILVTYSISIFLSVFLFTLVTHLSYMLIRYNAHGAHAKSSILCYIQSILTFVFVPYFLINIDINFTYLLALSIIGLISVVIYAPAATKKQPIPIKLVKRKKYLSIIMYLLVLILSLIIHPFYAQFMLLGILVESITLLPIFFPKED
>CP014064.2|AMG41763.1|1257981_1258125_+|cyclic-lactone-autoinducer-peptide
MNTLVNMFFDFIIKLAKAIGIVGGVNACSSLFDEPKVPAELTNLYDK

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Crispr_ID: CP014064_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP014064_3

1377485-1377565

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of CP014064_3

>merge|CP014064|3|1377485-1377565|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTCAACTTTAGTTGTTAGGGGCTTCT

>CP014064|3|3|1377485-1377565|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTT	ATGCATGCGCTTAGCGCAGGCGCTCCTACTTTT
CAACTTTAGTTGTTAGGGGCTTCT

Protein	Signature genes	Signature genes Name	Protein_function
CP014064.2\|AMG41882.1\|1379500_1380358_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
CP014064.2\|AMG41880.1\|1376376_1377468_+\|transcriptional-regulator	unknown	unknown	unknown
CP014064.2\|AMG41871.1\|1367970_1368681_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
CP014064.2\|AMG41875.1\|1372359_1372590_-\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG41876.1\|1372620_1373559_-\|mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
CP014064.2\|AMG41886.1\|1385498_1387631_+\|PRD-domain-containing-protein	unknown	unknown	gnl\|CDD\|226234
CP014064.2\|AVC42050.1\|1378437_1378620_-\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG41877.1\|1373994_1374660_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
CP014064.2\|AMG41883.1\|1380425_1381208_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
CP014064.2\|AMG41873.1\|1369444_1369858_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
CP014064.2\|AMG41884.1\|1381439_1383245_-\|glutamine--fructose-6-phosphate-aminotransferase	unknown	unknown	gnl\|CDD\|234729
CP014064.2\|AMG41879.1\|1375133_1376111_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
CP014064.2\|AMG41878.1\|1374811_1375132_+\|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
CP014064.2\|AVC42052.1\|1379279_1379372_+\|erm-Leader-peptide	unknown	unknown	unknown
CP014064.2\|AVC42051.1\|1378684_1378843_+\|integrase	unknown	unknown	unknown
CP014064.2\|AMG41885.1\|1383925_1385464_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
CP014064.2\|AMG41872.1\|1368801_1369245_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
CP014064.2\|AMG41887.1\|1387642_1388077_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	unknown	unknown	gnl\|CDD\|227014
CP014064.2\|AMG41881.2\|1377900_1378005_-\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG41874.1\|1370314_1371688_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640

Protein	Function_ID	Function_description	E-value
CP014064.2\|AMG41882.1\|1379500_1380358_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	6.8047e-59
CP014064.2\|AMG41871.1\|1367970_1368681_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
CP014064.2\|AMG41874.1\|1370314_1371688_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	4.11455e-06
CP014064.2\|AMG41886.1\|1385498_1387631_+\|PRD-domain-containing-protein	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	4.02509e-68
CP014064.2\|AMG41873.1\|1369444_1369858_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	3.14887e-46
CP014064.2\|AMG41877.1\|1373994_1374660_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.27122e-47
CP014064.2\|AMG41887.1\|1387642_1388077_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
CP014064.2\|AMG41883.1\|1380425_1381208_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.29094e-106
CP014064.2\|AMG41884.1\|1381439_1383245_-\|glutamine--fructose-6-phosphate-aminotransferase	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
CP014064.2\|AMG41879.1\|1375133_1376111_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.49165e-107
CP014064.2\|AMG41876.1\|1372620_1373559_-\|mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	7.24075e-129
CP014064.2\|AMG41885.1\|1383925_1385464_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
CP014064.2\|AMG41872.1\|1368801_1369245_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.22744e-67
CP014064.2\|AMG41878.1\|1374811_1375132_+\|ArsR-family-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17

>CP014064.2|AMG41880.1|1376376_1377468_+|transcriptional-regulator
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYAQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKDKKVVTEPKNTKVENGKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>CP014064.2|AMG41879.1|1375133_1376111_+|cation-transporter
MSHSHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>CP014064.2|AMG41878.1|1374811_1375132_+|ArsR-family-transcriptional-regulator
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>CP014064.2|AMG41877.1|1373994_1374660_-|SDR-family-NAD(P)-dependent-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFDGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGEQDIKDALTQFEIEKD
>CP014064.2|AMG41876.1|1372620_1373559_-|mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQHGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>CP014064.2|AMG41875.1|1372359_1372590_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>CP014064.2|AMG41874.1|1370314_1371688_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVKKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>CP014064.2|AMG41873.1|1369444_1369858_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIKLITALPNRTKLLGVGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>CP014064.2|AMG41872.1|1368801_1369245_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLENAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>CP014064.2|AMG41871.1|1367970_1368681_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>CP014064.2|AMG41881.2|1377900_1378005_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>CP014064.2|AVC42050.1|1378437_1378620_-|hypothetical-protein
MIIFRFKVNAFFPVKLCLMIRFCLESCCIFRRHLLITFHNIRSKFIMFKYISSKCIICTG
>CP014064.2|AVC42051.1|1378684_1378843_+|integrase
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>CP014064.2|AVC42052.1|1379279_1379372_+|erm-Leader-peptide
MTYGSIVAILCALFVIFFIPYMEKKDKKKK
>CP014064.2|AMG41882.1|1379500_1380358_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINQLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQITNLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>CP014064.2|AMG41883.1|1380425_1381208_-|ABC-transporter-ATP-binding-protein
MLIQLDQIGRMKQGKTILKNISWQIAKGDKWILYGLNGAGKTTLLNILNAYEPATTGGVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEVRNEAHHLLKLVGISAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLNILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>CP014064.2|AMG41884.1|1381439_1383245_-|glutamine--fructose-6-phosphate-aminotransferase
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEDGTPVVALATQENVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>CP014064.2|AMG41885.1|1383925_1385464_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>CP014064.2|AMG41886.1|1385498_1387631_+|PRD-domain-containing-protein
MLLSTREKEMIALLIKYHSQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGADSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVNKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDVDGNTSFENEQTSYLTSVFEKHLSDEKSEQLLHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLTLPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>CP014064.2|AMG41887.1|1387642_1388077_+|mannitol-specific-phosphotransferase-enzyme-IIA-component
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA

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Crispr_ID: CP014064_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP014064_4

1498845-1498925

Orphan

Consensus_repeat	Method
TCTATGTTGGGGCCCCGCCAACTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP014064_4

>merge|CP014064|4|1498845-1498925|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACTTGCACATTATTGTAAGCTGACTTTCTGTCAGCTTCTGTGTTGGGGCCCCGCCAACTTG

>CP014064|4|4|1498845-1498925|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACTTG	CACATTATTGTAAGCTGACTTTCTGTCAGCT
TCTGTGTTGGGGCCCCGCCAACTTG

Protein	Signature genes	Signature genes Name	Protein_function
CP014064.2\|AMG41992.1\|1495469_1496234_-\|VOC-family-protein	unknown	unknown	gnl\|CDD\|379203
CP014064.2\|AMG42002.1\|1501415_1501901_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|224677
CP014064.2\|AMG42006.1\|1504252_1505257_-\|molybdopterin-biosynthesis-protein-MoeB	unknown	unknown	gnl\|CDD\|181084
CP014064.2\|AMG41995.1\|1498141_1498492_-\|HTH-type-transcriptional-regulator-SarV	unknown	unknown	gnl\|CDD\|130944
CP014064.2\|AMG42004.1\|1503219_1503714_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	unknown	unknown	gnl\|CDD\|236483
CP014064.2\|AMG41996.1\|1498617_1498803_+\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG41993.1\|1496395_1496836_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
CP014064.2\|AMG41994.1\|1496828_1498040_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341042
CP014064.2\|AMG42001.1\|1500955_1501402_-\|molybdopterin-synthase-catalytic-subunit	unknown	unknown	gnl\|CDD\|223391
CP014064.2\|AMG41990.1\|1493572_1494838_-\|lipid-II:glycine-glycyltransferase-FemX	unknown	unknown	gnl\|CDD\|225224
CP014064.2\|AMG41991.1\|1495226_1495478_+\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG41987.1\|1488267_1488585_+\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG42000.1\|1500716_1500950_-\|molybdopterin-synthase-sulfur-carrier-subunit	unknown	unknown	gnl\|CDD\|340452
CP014064.2\|AMG41998.1\|1499068_1500091_-\|cyclic-pyranopterin-monophosphate-synthase	unknown	unknown	gnl\|CDD\|274250
CP014064.2\|AMG41999.1\|1500110_1500710_-\|molybdenum-cofactor-guanylyltransferase	unknown	unknown	gnl\|CDD\|234725
CP014064.2\|AMG42007.1\|1505426_1506032_-\|molybdenum-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226628
CP014064.2\|AMG41988.1\|1488837_1490157_+\|ISL3-like-element-IS1181-family-transposase	unknown	unknown	gnl\|CDD\|225995
CP014064.2\|AMG42003.1\|1501897_1503157_-\|molybdopterin-molybdenumtransferase-MoeA	unknown	unknown	gnl\|CDD\|238452
CP014064.2\|AMG41989.1\|1490288_1493456_-\|AcrB/AcrD/AcrF-family-protein	unknown	unknown	gnl\|CDD\|223911
CP014064.2\|AMG42005.1\|1503715_1504222_-\|molybdenum-cofactor-biosynthesis-protein	unknown	unknown	gnl\|CDD\|223595

Protein	Function_ID	Function_description	E-value
CP014064.2\|AMG41995.1\|1498141_1498492_-\|HTH-type-transcriptional-regulator-SarV	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.64009e-20
CP014064.2\|AMG42002.1\|1501415_1501901_-\|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B	gnl\|CDD\|224677	COG1763, MobB, Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism].	9.59347e-51
CP014064.2\|AMG42006.1\|1504252_1505257_-\|molybdopterin-biosynthesis-protein-MoeB	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	6.83722e-133
CP014064.2\|AMG41992.1\|1495469_1496234_-\|VOC-family-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	1.50083e-38
CP014064.2\|AMG42004.1\|1503219_1503714_+\|cyclic-pyranopterin-monophosphate-synthase-MoaC	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	2.93711e-97
CP014064.2\|AMG41993.1\|1496395_1496836_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.35323e-15
CP014064.2\|AMG41994.1\|1496828_1498040_+\|MFS-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.92881e-73
CP014064.2\|AMG42001.1\|1500955_1501402_-\|molybdopterin-synthase-catalytic-subunit	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	6.99133e-58
CP014064.2\|AMG41990.1\|1493572_1494838_-\|lipid-II:glycine-glycyltransferase-FemX	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	1.81413e-143
CP014064.2\|AMG42000.1\|1500716_1500950_-\|molybdopterin-synthase-sulfur-carrier-subunit	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	8.16473e-25
CP014064.2\|AMG41998.1\|1499068_1500091_-\|cyclic-pyranopterin-monophosphate-synthase	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.0538e-165
CP014064.2\|AMG41999.1\|1500110_1500710_-\|molybdenum-cofactor-guanylyltransferase	gnl\|CDD\|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	2.15389e-66
CP014064.2\|AMG42007.1\|1505426_1506032_-\|molybdenum-ABC-transporter-ATP-binding-protein	gnl\|CDD\|226628	COG4148, ModC, ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism].	1.78595e-116
CP014064.2\|AMG41988.1\|1488837_1490157_+\|ISL3-like-element-IS1181-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.75686e-114
CP014064.2\|AMG42003.1\|1501897_1503157_-\|molybdopterin-molybdenumtransferase-MoeA	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	3.61876e-159
CP014064.2\|AMG41989.1\|1490288_1493456_-\|AcrB/AcrD/AcrF-family-protein	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
CP014064.2\|AMG42005.1\|1503715_1504222_-\|molybdenum-cofactor-biosynthesis-protein	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	2.42221e-64

>CP014064.2|AMG41996.1|1498617_1498803_+|hypothetical-protein
MFRFISFGQLVVYSTTFIPKKDILQLNDLECDINVKEPLKINYVVIFGSGTEITFSQNLFR
>CP014064.2|AMG41995.1|1498141_1498492_-|HTH-type-transcriptional-regulator-SarV
MSNKVQRFIEAERELSQLKHWLKTTHKISIEEFVVLFKVYEAEKISGKELRDTLHFEMLWDTSKIDVIIRKIYKKELISKLRSETDERQVFYFYSTSQKKLLDKITKEIEVLSVTN
>CP014064.2|AMG41994.1|1496828_1498040_+|MFS-transporter
MTNQGSLNKSPIFTKSFTINFFVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLFIVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAVVTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILGILGLIISLFIKVDFEVTNNKTETDVINKPRFSIHQFIAKEAIPVAVIMLLIGVTYASILTYLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCLISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPSFLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
>CP014064.2|AMG41993.1|1496395_1496836_+|MarR-family-transcriptional-regulator
MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKHQPTTLIEISHRRAIEKPTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNISQDQMQETINVMNQIHEILLKEAHND
>CP014064.2|AMG41992.1|1495469_1496234_-|VOC-family-protein
MILKFDHIIHYIDQLDRFSFPGDVIKLHSGGYHHKYGTFNKLGYINENYIELLDVENNEKLKKMAKTIEGGVAFATQIVQEKYEQGFKNICLRTNDIEAVKNKLQSEQVEVVGPIQMERDTHKDGKVKWQLLYIMNQDDDEIKPPFFIQWEESDSMRTKKLQKYFQKQFSIETVIVKSKNRSQTVSNWLKWFDMDIVEENDHYTDLILKNDDIYFRIEDGKVSKYHSVIIKDAQATSPYSIFIRGAIYRFEPLV
>CP014064.2|AMG41991.1|1495226_1495478_+|hypothetical-protein
MRTIILSLFIIMNIVAIIMTLSQPLTVNYFSLRVILIFFTFILSIFFILIKSSRLNNILTILSIVLVIIHMGILAHSTYVYLY
>CP014064.2|AMG41990.1|1493572_1494838_-|lipid-II:glycine-glycyltransferase-FemX
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYILNQPLYQLIEQVKPRLTKAKIKISRKLKRK
>CP014064.2|AMG41989.1|1490288_1493456_-|AcrB/AcrD/AcrF-family-protein
MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLTLAGGQGQSQSQSDNKQNSAMSDVNQASPQQNSKASAPNNISGMPTAKLGDLADITVGDVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMVEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWIVIILSTLILVATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHVDGFKHPGEWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR
>CP014064.2|AMG41988.1|1488837_1490157_+|ISL3-like-element-IS1181-family-transposase
MCNDTLELLRIKDENIKYINQEIDVIIKGKKATVVNAVLTYKPSACYCCGVKNEGQIHKHGKRVSRITLLKTQGYNTYLNLAKQRFKCLECNGTFTAKTSIVDESCFISRCVTQKVIEEATKVKTEIDTAEDNCISPSTVSRIRTKAANSLRIKPFNCLPEHIAMDEFKSVKNVTGSMSFIFIDNDTHDVIDILENRTTRFLRAYFERFDLKNRQQVKTVTIDMYEPYVRLFRDLFPNAAIIFDRFHIVQHLNRELNKYRVQVMNEYRNKKGPNYTIFKNNWKVLLMDTSKTIFSKYRWNKSFKAYKRSSDIVEFMLSKDDILRRSYELVQGLRKDLRLCNWPKFINRLNSVSKKSVSKGVWKVVKYYRKHQRMLRNTIYYPAFNNGAIEGINNKIKLIKRISFGYRNFNNFKARIMMIFSLYKGEKKKTTKPNNGLAA
>CP014064.2|AMG41987.1|1488267_1488585_+|hypothetical-protein
MQFYLILLAILYLIVSFISIFKMEVVFTRILRIIMGVLLLFVLALTTMSFPKENWWVFIVLLLLVGNVEVTGFKMLKKDLKGVNILNLMSLFIFVIYFILTIVLF
>CP014064.2|AMG41998.1|1499068_1500091_-|cyclic-pyranopterin-monophosphate-synthase
MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
>CP014064.2|AMG41999.1|1500110_1500710_-|molybdenum-cofactor-guanylyltransferase
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNIYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
>CP014064.2|AMG42000.1|1500716_1500950_-|molybdopterin-synthase-sulfur-carrier-subunit
MKVLYFAEIKDILQKAQEDIVLEQALTVQQFEDLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
>CP014064.2|AMG42001.1|1500955_1501402_-|molybdopterin-synthase-catalytic-subunit
MKQFEIVIEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>CP014064.2|AMG42002.1|1501415_1501901_-|molybdopterin-guanine-dinucleotide-biosynthesis-protein-B
MILQIVGYKKSGKTTLMRHIVSFLKTHGYTVATIKHHGHAKEDIQLQDSDVDHMKHFEAGADQSIVQGFQYQQTVTRVDNQNLTQIIEKSVTIDTNIVLVEGFKNADFEKVVVYRDEEELQVLQQLSNVCYSINVREHEDFTAFEQWLLNKIKNDCDTQLT
>CP014064.2|AMG42003.1|1501897_1503157_-|molybdopterin-molybdenumtransferase-MoeA
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETKTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAKKLGLEVGIYKTQKDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
>CP014064.2|AMG42004.1|1503219_1503714_+|cyclic-pyranopterin-monophosphate-synthase-MoaC
MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIFKQISNNTNTKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSGQ
>CP014064.2|AMG42005.1|1503715_1504222_-|molybdenum-cofactor-biosynthesis-protein
MGEHQNVKLNRTVKAAVLTVSDTRDFVTDKGGQCVRQLLQADDVEVSDAHYTIVKDEKVAITTQVKKWLEEDIDVIITTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPELNHLIHELTK
>CP014064.2|AMG42006.1|1504252_1505257_-|molybdopterin-biosynthesis-protein-MoeB
MSQERYSRQILFKQIGEIGQSKINQKCALIIGMGALGTHVAEGLVRAGIAKLIIVDRDYIEFSNLQRQTLFTEEDALKMMPKVVAAKKHLLALRSDVDIDGCIAHVDYYFLETHGQDVDVIIDATDNFETRQLINDFAYKHRIPWIYGGVVQSTYTEAAFIPGKTPCFNCLVPQLPALNLTCDTVGVIQPAVTMATSLQLRDAMKVLTEQPIDTKITYGDIWEGSHYSFGFSKMQRSDCTTCGDVPSYPYLNKNEQRYATLCGRDTVQYENASITHDILVQFLKQHQLNYRSNSYMVMFEFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG
>CP014064.2|AMG42007.1|1505426_1506032_-|molybdenum-ABC-transporter-ATP-binding-protein
MLKINVKYQLKNTLIRINIDDTEPKIYAVRGPSGIGKTTVLNMIAGLRKADEAIIEVNGQLLTDTTKNVNVKIQQRRIGYLFQDYQLFPNMTVYKNITFMAEPSKHIDQLIQTLNINHLMKQYPMTLSGGEAQRVALARALSTKPDLILLDEPFSSLDDTTKDESITLVKRIFNEWQIPIIFVTHSNYEAEQMAHEIITIG

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Crispr_ID: CP014064_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP014064_5

2115344-2115428

Orphan

Consensus_repeat	Method
TTCTACAGGCAATGCAAGTTGGGGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP014064_5

>merge|CP014064|5|2115344-2115428|CRISPRCasFinder
TTCTACAGGCAATGCAAGTTGGGGTGTGGGCCCCAACAAAGAGAAATTGGATTCCCAATTTCTACAGACAATGCAAGTTGGGGTG

>CP014064|5|5|2115344-2115428|CRISPRCasFinder
TTCTACAGGCAATGCAAGTTGGGGTG	TGGGCCCCAACAAAGAGAAATTGGATTCCCAAT
TTCTACAGACAATGCAAGTTGGGGTG

Protein	Signature genes	Signature genes Name	Protein_function
CP014064.2\|AMG42571.1\|2116725_2117466_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
CP014064.2\|AMG42567.1\|2114235_2115195_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
CP014064.2\|AMG42569.1\|2115489_2115693_-\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG43235.1\|2121002_2122028_+\|formate-dehydrogenase	unknown	unknown	gnl\|CDD\|181041
CP014064.2\|AMG42562.1\|2108409_2109672_+\|nucleotide-sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|223749
CP014064.2\|AMG42558.1\|2104489_2105695_+\|capsular-biosynthesis-protein	unknown	unknown	unknown
CP014064.2\|AMG42566.1\|2112101_2113589_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143435
CP014064.2\|AMG42559.1\|2105695_2106901_+\|glycosyltransferase-WbuB	unknown	unknown	gnl\|CDD\|340825
CP014064.2\|AMG42564.1\|2110958_2111285_-\|staphylobilin-forming-heme-oxygenase-IsdI	unknown	unknown	gnl\|CDD\|183968
CP014064.2\|AMG42573.1\|2118447_2119209_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
CP014064.2\|AMG42560.1\|2106911_2107469_+\|sugar-transferase	unknown	unknown	gnl\|CDD\|225059
CP014064.2\|AMG42561.1\|2107468_2108356_+\|UDP-glucose-4-epimerase	unknown	unknown	gnl\|CDD\|187543
CP014064.2\|AMG42572.1\|2117479_2118451_+\|nitrate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270271
CP014064.2\|AMG42576.1\|2122413_2123664_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
CP014064.2\|AMG43236.1\|2124110_2131286_+\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
CP014064.2\|AMG42570.1\|2115871_2116384_+\|DUF4242-domain-containing-protein	unknown	unknown	gnl\|CDD\|379428
CP014064.2\|AMG42574.2\|2119221_2120253_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
CP014064.2\|AMG42575.1\|2120469_2120829_+\|DUF2294-domain-containing-protein	unknown	unknown	gnl\|CDD\|227896
CP014064.2\|AMG42565.1\|2111291_2111675_-\|DUF454-domain-containing-protein	unknown	unknown	gnl\|CDD\|377291
CP014064.2\|AMG42563.1\|2109748_2110894_+\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	unknown	unknown	gnl\|CDD\|223458

Protein	Function_ID	Function_description	E-value
CP014064.2\|AMG42567.1\|2114235_2115195_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	4.11026e-108
CP014064.2\|AMG42570.1\|2115871_2116384_+\|DUF4242-domain-containing-protein	gnl\|CDD\|379428	pfam14026, DUF4242, Protein of unknown function (DUF4242). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.	2.56603e-26
CP014064.2\|AMG43235.1\|2121002_2122028_+\|formate-dehydrogenase	gnl\|CDD\|181041	PRK07574, PRK07574, NAD-dependent formate dehydrogenase.	0
CP014064.2\|AMG42562.1\|2108409_2109672_+\|nucleotide-sugar-dehydrogenase	gnl\|CDD\|223749	COG0677, WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane].	0
CP014064.2\|AMG42576.1\|2122413_2123664_+\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.61322e-72
CP014064.2\|AMG42566.1\|2112101_2113589_+\|aldehyde-dehydrogenase	gnl\|CDD\|143435	cd07117, ALDH_StaphAldA1, Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like. Uncharacterized aldehyde dehydrogenase from Staphylococcus aureus (AldA1, locus SACOL0154) and other similar sequences are present in this CD.	0
CP014064.2\|AMG42559.1\|2105695_2106901_+\|glycosyltransferase-WbuB	gnl\|CDD\|340825	cd03794, GT4_WbuB-like, Escherichia coli WbuB and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.	3.56278e-74
CP014064.2\|AMG42564.1\|2110958_2111285_-\|staphylobilin-forming-heme-oxygenase-IsdI	gnl\|CDD\|183968	PRK13313, PRK13313, staphylobilin-forming heme oxygenase IsdI.	1.40112e-64
CP014064.2\|AMG42573.1\|2118447_2119209_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	1.22607e-73
CP014064.2\|AMG42560.1\|2106911_2107469_+\|sugar-transferase	gnl\|CDD\|225059	COG2148, WcaJ, Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane].	3.08096e-87
CP014064.2\|AMG42561.1\|2107468_2108356_+\|UDP-glucose-4-epimerase	gnl\|CDD\|187543	cd05232, UDP_G4E_4_SDR_e, UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. This subgroup is comprised of bacterial proteins, and includes the Staphylococcus aureus capsular polysaccharide Cap5N, which may have a role in the synthesis of UDP-N-acetyl-d-fucosamine. This subgroup has the characteristic active site tetrad and NAD-binding motif of the extended SDRs. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.93098e-117
CP014064.2\|AMG42572.1\|2117479_2118451_+\|nitrate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270271	cd13553, PBP2_NrtA_CpmA_like, Substrate binding domain of ABC-type nitrate/bicarbonate transporters, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes nitrate (NrtA) and bicarbonate (CmpA) receptors. These domains are found in eubacterial perisplamic-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. These binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	6.75927e-52
CP014064.2\|AMG43236.1\|2124110_2131286_+\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
CP014064.2\|AMG42571.1\|2116725_2117466_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	2.18703e-112
CP014064.2\|AMG42574.2\|2119221_2120253_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	2.67474e-20
CP014064.2\|AMG42575.1\|2120469_2120829_+\|DUF2294-domain-containing-protein	gnl\|CDD\|227896	COG5609, COG5609, Uncharacterized conserved protein [Function unknown].	6.06834e-49
CP014064.2\|AMG42565.1\|2111291_2111675_-\|DUF454-domain-containing-protein	gnl\|CDD\|377291	pfam04304, DUF454, Protein of unknown function (DUF454). Predicted membrane protein.	5.80598e-41
CP014064.2\|AMG42563.1\|2109748_2110894_+\|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)	gnl\|CDD\|223458	COG0381, WecB, UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane].	0

>CP014064.2|AMG42567.1|2114235_2115195_+|cation-transporter
MNGKKANTINRYKYFHHVNHQKIQQSSKKTLWASLIITLLFTVIEFVGGLVSNSLALLSDSFHMLSDVLALGLSMLAIYFASKKPTARYTFGYLRFEILVAFLNGLALIVISIWILYEAIVRIIYPQPIESGIMFMIASIGLLVNIILTIILVRSLKQEDNINIQSALWHFMGDLLNSIGVIVAVVLIYFTGWRIIDPIISIVISLIILRGGYKITRNAWLILMESVPQHLDTDQIMADIKNIDGILDVHEFHLWSITTEHYSLSAHVVLDKKYEGDDYQAIDQVSSLLKEKYGIAHSTLQIENLQLNPLDEPYFDKLT
>CP014064.2|AMG42566.1|2112101_2113589_+|aldehyde-dehydrogenase
MAVNVRDYIAENYGLFINGEFVKGSSDETIEVTNPATGETLSHITRAKDKDVDHAVKVAQEAFESWSLTSKSERAQMLRDIGDKLMAQKDKIAMIETLNNGKPIRETTAIDIPFAARHFHYFASVIETEEGTVNDIDKDTMSIVRHEPIGVVGAVVAWNFPMLLAAWKIAPAIAAGNTIVIQPSSSTPLSLLEVAKIFQEVLPKGVVNILTGKGSESGNAIFNHDGVDKLSFTGSTDVGYQVAEAAAKHLVPATLELGGKSANIILDDANLDLAVEGIQLGILFNQGEVCSAGSRLLVHEKIYDQLVPRLQEAFSNIKVGDPQDEATQMGSQTGKDQLDKIQSYIDAAKESDAQILAGGHRLTENGLDKGFFFEPTLIAVPDNHHKLAQEEIFGPVLTVIKVKDDQEAIDIANDSEYGLAGGVFSQNITRALNIAKAVRTGRIWINTYNQVPEGAPFGGYKKSGIGRETYKGALSNYQQVKNIYIDTSNALKGLY
>CP014064.2|AMG42565.1|2111291_2111675_-|DUF454-domain-containing-protein
MRLILIVIGLIFTALGIAGAVLPLLPTTPFLLVAVFCFARSSDRFYNWLINQKIYKEYVENFYLHRGYTLQQKIKILISLYIVIGFSIYMVDVLAVRVGLIIMVIIQTAVLFTFVKTLPKSNHKIEE
>CP014064.2|AMG42564.1|2110958_2111285_-|staphylobilin-forming-heme-oxygenase-IsdI
MFMAENRLQLQKGSAEETIERFYNRQGIETIEGFQQMFVTKTLNTEDTDEVKILTIWESEDSFNNWLNSDVFKEAHKNVRLKSDDDGQQSPILSNKVFKYDIGYHYQK
>CP014064.2|AMG42563.1|2109748_2110894_+|UDP-N-acetylglucosamine-2-epimerase-(non-hydrolyzing)
MKKIMVIFGTRPEAIKMAPLVKEIDHNGNFEANIVITAQHRDMLDSVLSIFDIQADHDLNIMQDQQTLADLTANALAKLDSIINEEQPDMILVHGDTTTTFVGSLAAFYHQIPVGHVEAGLRTHQKYSPFPEELNRVMVSNIAELNFAPTVIAAKNLLFENKDKERIFITGNTVIDALSTTVQNDFVSTIINKHKGKKVILLTAHRRENIGEPMHQIFKAVRDLADEYKDVVFIYPMHRNPKVRAIAEKYLSGRNRIELIEPLDAIEFHNFTNQSYLVLTDSGGIQEEAPTFGKPVLVLRNHTERPEGVEAGTSRVIGTDYDNIVRNVKQLIEDDEAYQRMSQANNPYGDGQASRRICEAIEYYFGLRSDKPDEFVPLRHK
>CP014064.2|AMG42562.1|2108409_2109672_+|nucleotide-sugar-dehydrogenase
MKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQSGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLEKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDICLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKYVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVSYYNYGNIFNFIDK
>CP014064.2|AMG42561.1|2107468_2108356_+|UDP-glucose-4-epimerase
MRKNILITGVHGYIGNALKDKLIEQGHQVDQINVRNQLWKSTSFKDYDVLIHTAALVHNNSPQARLSDYMQVNMLLTKQLAQKAKAEDVKQFIFMSTMAVYGKEGQVGKSDQIDTQTPMNPTTNYGISKKFAEQALQELISDSFKVAIVRPPMIYGAHCPGNFQRLMQLSKRLPIIPNINNQRSALYIKHLTAFIDQLISLEVTGVYHPQDSFYFDTSSVMYEIRRQSHRKTVLINMPSVLNKYFNKLSVFRKLFGNLTYSNTLYENNNALEVIPGKMSLVIADIMDETTTKDKA
>CP014064.2|AMG42560.1|2106911_2107469_+|sugar-transferase
MKRLFDVVSSIYGLVVLSPILLITALLIKMESPGPAIFKQKRPTINNELFNIYKFRSMKIDTPNVATDLMDSTSYITKTGKVIRKTSIDELPQLLNVLKGEMSIVGPRPALYNQYELIEKRTKANVHTIRPGVTGLAQVMGRDDITDDQKVAYDHYYLTHQSMMLDMYIIYKTIKNIVTSEGVHH
>CP014064.2|AMG42559.1|2105695_2106901_+|glycosyltransferase-WbuB
MSEKKILILCQYFYPEYVSSATLPTQLAEDLIANHINVDVMCGWPYEYSNHKQVSKTEMHRGIRIRRLKYSRFNNKSKVGRIINFFSLFSKFVINIPKMLKYDQILVYSNPPILPLIPDVLHRLLKKKYSFVVYDIAPDNAIKTGATRPGSMIDKLMRYINRHVYKNAENVIVLGTEMKNYLLNHQISKNADNIHVIPNWYDMRQLQDNRIYNDTFKAYREQYDKILLYSGNMGQLQDMETLISFLKLNKDQPQTLTILCGHGKKFADVKTAIEDHRIENVKMFEFLTGTDYADVLKIADVCIASLIKEGVGLGVPSKNYGYLAAKKPLVLIMDKQSDIVQHVEQYDAGIQIDNGDAHAIYNFINTHSSKELHEMGERAHQLFKDKYTREINTMKYYNLLK
>CP014064.2|AMG42558.1|2104489_2105695_+|capsular-biosynthesis-protein
MVKKVFIMDSVKTIIGTLLIALGLQFLAYPIINQRVGNEAFGSILTIYTIITITSVVLGNTLNNIRLINMNLYKSNHYYWKFVSILLISILIESIALIIVFLYFFNLNTIDIIFLILLNILMCLRIYLNVFFRMTLKYNQILYIALIQFLGLLIGLFLYYLIQNWIVCFITSELFATIYTLVKLRGLTIGEYQSEDNNVVKDYVMLLSTNSLNNLNLYLDRLILLPIIGGTAVTISFLSTFIGKMLATFLYPINNVVLSYISVNESDNIKKQYLKTNLFAIAALCLVMIICYPITLIIVSLLYNIDSSLYSKFIILGNIGVLFNAVSIMIQTLNTKHASITLQANYMTLHTITFIFITILMTIAFGLNGFFWTTLFSNIIKYVILNIIGLKSKFINKKDVD
>CP014064.2|AMG42569.1|2115489_2115693_-|hypothetical-protein
MDKESVVASLARNKKIAVETMAGQRYIIERILHTNDEKHIHILKPKDVVLDVDSIKEIDENHLNDAT
>CP014064.2|AMG42570.1|2115871_2116384_+|DUF4242-domain-containing-protein
MTLFLLEANNLDFASTKEELEAKAASLSTKTIPTLIEVQATENLTHGYFIVEANDEAEAKQFLTEADISIQLVKEVRLVGKDLDEVKNGDAHVDYLVTWNIPEGITMDQYLARKKKNSVHYEEVPEVEFKRTYVCEDMSKCICLYNAPDEEAVRRARKAVDTPIDGIEKL
>CP014064.2|AMG42571.1|2116725_2117466_+|ABC-transporter-ATP-binding-protein
MIKIQQLQHHFGSHKVIHNFNLDISKGEIVTFIGKSGCGKSTLLNVIGGFIHPSSGRVIIDNEIKQQPSPDCLMLFQHHNLLPWKTINDNIRIGFQQKISDEEINAQLKLVDLEDRGKHFPEQLSGGMKQRVALCRAHVHKPNVILMDEPLGALDAFTRYKLQDQLVQLKHKTQSTIILVTHDIDEAIYLSDRIVLLGEGCNIISQYEITASHPRSRNDSHLLKIRNEIMETFALNHHQVEPEYYL
>CP014064.2|AMG42572.1|2117479_2118451_+|nitrate-ABC-transporter-substrate-binding-protein
MKRLSIIVIIGIFIITGCDWQRTSKEPSKNAQNQQVIKIGYLPITHSANLMMTKKLLSQYNHPKYKLELVKFNNWPDLMDALNSGRIDGASTLIELAMKSKQKGSNIKAVALGHHEGNVIMGQKGMHLNEFNNGDDYHFGIPHRYSTHYLLLEELRKQLKIKPGHFSYHEMSPAEMPAALSEHRITGYSVAEPFGALGEKLGKGKTLKHGDDVIPDAYCCVLVLRGELLDQHKDVAQAFVQDYKKSGFKMNDRKQSVDIMTHHFKQSRDVLTQSAAWTSYGDLTIKPSGYQEITTLVKQHHLFNPPAYDDFVEPSLYKEASRS
>CP014064.2|AMG42573.1|2118447_2119209_+|ABC-transporter-permease
MTRPTNNKFILPIITFIIFLGIWEMVIIIGHYQPVLLPGPALVGKSIWTFIVTGEIFQHLAISLWRFVAGFVVALLVAIPLGFLLGRNRWLYNAIEPLFQLIRPISPIAWAPFVVLWFGIGSLPAIAIIFIAAFFPIVFNTIKGVRDIEPQYLKIAANLNLTGWSLYRNILFPGAFKQIMAGIHMAVGTSWIFLVSGEMIGAQSGLGFLIVDARNMLNLEDVLAAIFFIGLFGFIIDRFISYIEQFILRRFGE
>CP014064.2|AMG42574.2|2119221_2120253_+|acyl-CoA-dehydrogenase
MTLETLIKEQLDPHLVEVDEGTYYPRTFIQQLFVDGYFGEAALRKNAEVIEAVSQSCLTTGFCLWCQLAFSTYLENATQPHLNNDLQQQLLSGEILGATGLSNPMKSFNDLEKLNLEHTYVDGQLVVSGRMPAVSNIQEDHYFGAISKHESSDEFVMFILRANQDGITLVEKTNFLGVNGSATYQITLNQVVVPQSQIITHDAKQFAATIRPQFIAYQIPIGLGSIKSSLELIDAFSNAQNGINQYLEYDVEAFKKRYRQLREEYYAILDDGNLTSHLSELISLKKDIGYLLLDVNQASVVNGGSRAYTPYSPQVRKLKEGFFFAALTPTLRHLGKLEAELKG
>CP014064.2|AMG42575.1|2120469_2120829_+|DUF2294-domain-containing-protein
MNTIDTHTKEQQFSNLVRSYRKEYVGKGPNSIRVSFKDNWAIAHMTGVLSKVESFYLNDKRNESMLHYTRTEKIKQMYKEIDVNEMESLVGAKFVKLFTDIDLNDDEVISIFVFDKSIE
>CP014064.2|AMG43235.1|2121002_2122028_+|formate-dehydrogenase
MKIVALFPEAVEGQENQLLNTKKAIGLKTFLEERGHEFIILADNGEDLDKHLPDMDVIISAPFYPAYMTRERIEKAPNLKLAITAGVGSDHVDLAAASEHNIGVVEVTGSNTVSVAEHAVMDLLILLRNYEEGHRQSVEGEWNLSQVGNHAHELQHKTIGIFGFGRIGQLVAERLAPFNVTLQHYDPINQQDHKLSKFVSFDELVSSSDAITIHAPLTPETDNLFDKDVLSRMKKHSYLVNTARGKIVNRDALVEALASEHLQGYAGDVWYPQPAPADHPWRTMPRNAMTVHYSGMTLEAQKRIEDGVKDILERFFNHEPFQDKDIIVASGRIASKSYTAK
>CP014064.2|AMG42576.1|2122413_2123664_+|MFS-transporter
MKRLSTTLKVRLISNFLQLIITTAFIPFIALYLTDMLSQSIVGIYLVGLVVLKFPLSIISGYLIEIFPKKLLVLIYQATMVIMLVFMGVFGSHQLWQIIGFCVAYAIFTIVWGLQFPVMDTLIMDAITEDVEHYIYKISYWMTNLSVAIGALLGGLMYGYSMLLLFLIAACIFLIVLFILYIWLPQDRNQVKQSDDKRHASRYQKLQIMNIFRSYKLVLKDRNYMLLISGFSIIMMGEFSISSYIAIRLKDQFETISIGSYDITGAKMLAILLMINTVVVILLTYSISKVVLKIDFKKALITGLLIYIVGYSGLTYLNQFGLLVVFMIIATVGEIIYSPIVSEQRFKIIPKAKRGTYSAVNALGIHFSETLARLGIVLGVFLTSLQMGLYMFIVLTIGASMLVAGVFGGQKQVNTN
>CP014064.2|AMG43236.1|2124110_2131286_+|non-ribosomal-peptide-synthetase
MIMGNLRFQQEYFRIYKNNTESTTHRNAYWVKLAKNVEATKMMYALSTIVQQHASIRHFFDVTTDDNLTMILHEFLPFIEIKQVPSSSANYDLEAFFKQELSTYHFNDSPLFKVKLFQFADAAYILLDFHVSIFDDSQIDIFLDDLCNAYRGNTVINNTRQHAHINRNDDKDNQDASHIALDSNYFRLENNSDIHIDSYFPIKHPFEQALYQTYLIDDMTSIDMASLAVSVYLANHIMSQQHDVTLGIHVPSHLPNDLHGNIVPLTLTIDAKDVCQRFTTDFNKCVLQNMSQLQCAKSSLSLETIFHCYHHMMSCCNDVIEDVHQIHDAHTSLADIEIFPHQHGFKIIYNSAAYDLLSIETLSDLVRNIYLQITEENGNKRTTVDELNLMTERDIQLYDDINLSLPEIDDAQTVVTLFEQQVEATPNHVAVQFDGVFITYQTLNARANDLAHRLRNQYGVEPNDRVAVIAEKSIEMIIAMIGVLKAGGAYVPIDPNYPSDRQEYILKDATPKVVITYQALYENGKQNINHIDLNKIAWKNIDNLSKCNTLEDHAYVIYTSGTTGNPKGTLIPHRGIVRLVHRNHYVPLNEETTILLSGTIAFDAATFEIYGALLNGGKLIVAKKEQLLNPIAVEQLINENDVNTMWLTSSLFNQIASERIEVLVPLKYLLIGGEVLNAKWVDLLNQKPKHPQIINGYGPTENTTFTTTYNIPNKVPNRIPIGKPILGTHVYIMQGERRCGVGIPGELCTSGFGLAAGYLNQPELTADKFIKDSNINQLMYRSGDIVRLLPDGNIDYLYRKDKQVKIRGFRIELSEVEHALERIQGINKAVVIVQNHDQDQYIVAYYEAMHTLSHNKIKSQLRMTLPEYMIPVNFMHIEQIPITINGKLDKKALPIMDYVDTDAYVAPSTDTEHLLCQIFADILHVNQVGIHDNFFELGGHSLKATLVVNRIEASTGKRLQIGDLLQKPTVFELAQAIAKVQEQNYEVIPEAIVKDDYVLSSAQKRMYLLWKSNHKDTVYNVPFLWRLSSGLNVAQLQQAVQHLIARHEILRTQYIVVDDEVRQRIVADVVADFEEVNTHFTDEQEIMRQFVAPFNLEKPSQIRVRYIRSPLHAYLFIDTHHIINDGMSNIQLMNDLNALYQHKLLLPLKLQYKDYSEWMSHRDMTKHRQYWLSQFKDEVPILSLPTDYVRPNIKTTNGAMMSFTMNQQMRQLLQKYVEKHQITDFMFFMSVVMTLLSRYARKDDVVVGSVMSARMHKGTEQMLGMFANTLVYRGQPSPDKMWTQFLQEVKEMSLEAYEHQEYPFECLVNDLDQSHDASRNPLFDVMLVLQNNETNHAHFGHSKLTHIQPKSVTAKFDLSFIIEEDRDDYTINIEYNTDLYHSETVRHMGNQCMIMIDYILKHQDTLQICDIPNGTEELLNWVNTHVNDRMLNVPGNKSIISYFNEVVSRQGNHVALVMNDLTMTYETLRNYVDAIAHMLLSNGVGNGQRVALFTERSFEMIAAMLATVKVGASYIPIDIDFPNKRQGAILEDAKVTAVMSYGVEIETTLPVIQLENAKGFVESKENEQYDDLHGNQLENTAMLDNEMYAIYTSGTTGMPKGVAIRQRNLLNLVHAWSTELQLGDNEVFLQHANIVFDASVMEIYCCLLNGHTLVIPDREERVNPEQLQQLINKHRVTVASIPLQMCSIMEDFYIEKLITGGATSTASFVKYIEKHCGTYFNAYGPSESTVITSYWSHHCGDLIPETIPIGKPLSNIQVYIMSDGLLCGIGMPGELCIAGDSLAIGYINRPELMADKWQNNPFGKGKLYHSGDLARYTSDGQIEFLGRIDKQVKVNGYRIELDEIENVILAIRGISDCVVTVSHFDTHDILNAYYVGEQQVEQDLKQYLNDQLPKYMIPKTITHIDCMPLTTNDKVDTTRLPNPSPIQQSNKVYSEPSNEIEQTFVDVFGEVLKQNDVGVDDDFFELGGNSLEAMLVVSHLKRFGHHISMQTLYQYKTVRQIVNYMYQNQQSLVALPDNLSELQKIVMSRYNLGILEDSLSHRPLGNTLLTGATGFLGAYLIEALQGYSHRIYCFIRADNEEIAWYKLMTNLNDYFSEETVEMMLSNIEVIVGDFECMDDVVLPENMDTIIHAGARTDHFGDDDEFEKVNVQGTVDVIRLAQQHHARLIYVSTISVGTYFDIDTEDVTFSEADVYKGQLLTSPYTRSKFYSELKVLEAVNNGLDGRIVRVGNLTSPYNGRWHMRNIKTNRFSMVMNDLLQLDCIGVSMAEMPVDFSFVDTTARQIVALAQVNTPQIIYHVLSPNKMPVKSLLECVKRKEIELVSDESFNEILQKQDMYETIGLTSVDREQQLAMIDTTLTLKIMNHISEKWPTITNNWLYHWAQYIKTIFNK

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Crispr_ID: CP014064_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP014064_6

2353103-2353204

Orphan

Consensus_repeat	Method
TTATGAATTGAGTATTAAATTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP014064_6

>merge|CP014064|6|2353103-2353204|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTGAAAGTAAATTACAGTTCTATAGGTTTATAAAAAATCAGTTTTTAAATCAAAGCTATATATGAATTGAGTATTAAATTTG

>CP014064|6|6|2353103-2353204|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTG	AAAGTAAATTACAGTTCTATAGGTTTATAAAAAATCAGTTTTTAAATCAAAGCTAT
ATATGAATTGAGTATTAAATTTG

Protein	Signature genes	Signature genes Name	Protein_function
CP014064.2\|AMG42795.1\|2361976_2362681_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl\|CDD\|367091
CP014064.2\|AMG42780.1\|2346349_2346976_-\|NDxxF-motif-lipoprotein	unknown	unknown	gnl\|CDD\|380196
CP014064.2\|AMG42793.1\|2359394_2360936_+\|GMP-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl\|CDD\|234614
CP014064.2\|AMG42785.1\|2350854_2352243_-\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
CP014064.2\|AMG42784.1\|2350019_2350775_+\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|380322
CP014064.2\|AMG42788.1\|2354294_2354957_-\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG42789.1\|2355099_2355507_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378584
CP014064.2\|AMG42790.1\|2356019_2356598_+\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
CP014064.2\|AMG42778.1\|2345049_2345631_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
CP014064.2\|AMG42791.1\|2356597_2357866_+\|purine-permease	unknown	unknown	gnl\|CDD\|274468
CP014064.2\|AMG42777.1\|2344662_2344872_-\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG42796.1\|2363079_2363352_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225511
CP014064.2\|AMG42787.1\|2353220_2354177_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
CP014064.2\|AMG42783.1\|2348958_2349528_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|211789
CP014064.2\|AVC42081.1\|2352636_2352894_-\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG42794.1\|2361048_2361585_-\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG42779.1\|2345696_2346080_-\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG42792.1\|2357903_2359370_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
CP014064.2\|AMG42786.1\|2352327_2352426_+\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG42782.1\|2347419_2348943_-\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942

Protein	Function_ID	Function_description	E-value
CP014064.2\|AMG42780.1\|2346349_2346976_-\|NDxxF-motif-lipoprotein	gnl\|CDD\|380196	NF033193, lipo_NDxxF, NDxxF motif lipoprotein. Members of this family are lipoproteins, about 200 amino acids long in precursor form, found in Staphylococcus aureus, Bacillus cereus, and various other Firmicutes. The protein family is named for one of its several highly conserved motifs.	1.15385e-71
CP014064.2\|AMG42793.1\|2359394_2360936_+\|GMP-synthase-(glutamine-hydrolyzing)	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
CP014064.2\|AMG42785.1\|2350854_2352243_-\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
CP014064.2\|AMG42784.1\|2350019_2350775_+\|NADPH-dependent-oxidoreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	4.50551e-88
CP014064.2\|AMG42796.1\|2363079_2363352_-\|hypothetical-protein	gnl\|CDD\|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	9.23077e-11
CP014064.2\|AMG42790.1\|2356019_2356598_+\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	9.01486e-119
CP014064.2\|AMG42778.1\|2345049_2345631_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	2.4566e-49
CP014064.2\|AMG42791.1\|2356597_2357866_+\|purine-permease	gnl\|CDD\|274468	TIGR03173, pbuX, xanthine permease. All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.	5.74823e-170
CP014064.2\|AMG42787.1\|2353220_2354177_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00265416
CP014064.2\|AMG42795.1\|2361976_2362681_-\|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	5.38181e-08
CP014064.2\|AMG42789.1\|2355099_2355507_-\|hypothetical-protein	gnl\|CDD\|378584	pfam11181, YflT, Heat induced stress protein YflT. YflT is a heat induced protein.	2.17298e-12
CP014064.2\|AMG42792.1\|2357903_2359370_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
CP014064.2\|AMG42783.1\|2348958_2349528_-\|peroxiredoxin	gnl\|CDD\|211789	TIGR03137, AhpC, peroxiredoxin. This peroxiredoxin (AhpC, alkylhydroperoxide reductase subunit C) is one subunit of a two-subunit complex with subunit F(TIGR03140). Usually these are found as an apparent operon. The gene has been characterized in Bacteroides fragilis, where it is important in oxidative stress defense. This gene contains two invariant cysteine residues, one near the N-terminus and one near the C-terminus, each followed immediately by a proline residue. [Cellular processes, Detoxification, Cellular processes, Adaptations to atypical conditions].	1.50623e-124
CP014064.2\|AMG42782.1\|2347419_2348943_-\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0

>CP014064.2|AVC42081.1|2352636_2352894_-|hypothetical-protein
MLVNDESHKGTLIFTFTTNAFFLKQKYLFTVAFELPPAHTNPQKMLILIRQNFLQRVCSKRLFKVDHLLSFYSINMRLAIFIKPS
>CP014064.2|AMG42786.1|2352327_2352426_+|hypothetical-protein
MQLNVNMMKFDRWHKGICKQIVLNLVEKGEKG
>CP014064.2|AMG42785.1|2350854_2352243_-|L-cystine-transporter
MNAFLTLINIIVLVIFIVILHMMARKHISFAKRVFTALGIGIVFGVLLHLVYGTHSNVITSTSDWFNIVGQGYVALLQMIVMPLIFISIVAAFTKIQIGEKFAKIGSLIFIFLIGTVTIAAIVGVVYALVFGLDASTINLGNAEQARGSEIAKQAKDLTAHTLPQQILELLPKNPFLDFTGQRATSTIAVVIFASFIGFAYLRVARKQPDHGELLKRAIDAIYSLVMAIVTFVLRLTPYGVLAIMANTLSTSDFGAIWTLGKFLIASYAALITMYIIHLIILSLLGISPIRYVKKTLEVLIFAFTSRSSAGALPLNVQTQTRRLGVPEGIANFAATFGLSIGQNGCAGIYPAMLAIMVAPVANVEIDLQFIVTLIAVVIISSFGVAGVGGGATFASILVLSTLNLPVALAGVLISVEPLIDMGRTALNVNDSMLAGTGTAKLTKHWDKDTFESNDNAALTSH
>CP014064.2|AMG42784.1|2350019_2350775_+|NADPH-dependent-oxidoreductase
MSDYVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKENLREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAENIAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPFDHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDMLEQLQKSGLIQR
>CP014064.2|AMG42783.1|2348958_2349528_-|peroxiredoxin
MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLAQRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQPGLDLVGKI
>CP014064.2|AMG42782.1|2347419_2348943_-|alkyl-hydroperoxide-reductase-subunit-F
MLNADLKQQLKQLLELMEGNVEFVASLGSDEKSKELKELLTEISDMSPRLSLSEKSLKRTPSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKNLEGSFHFETFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNGRMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGGQVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENGAVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEAAIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYEDMSTGEEHLLNLDGIFVQIGLLPNTSWLKDAVELNERGEIVIDRNNNTNVPGIFAAGDVTDQKNKQIIISMGAGANAALNAFDYIIRN
>CP014064.2|AMG42780.1|2346349_2346976_-|NDxxF-motif-lipoprotein
MKKRLLLSTFLASALILTGCASDQSDNEDHHTSTGIHAPKSAKKLETKDIFNSDKKNSDISDAEMKQAIEKYLSVNSDILDNKYIMQHKLDKQIDSQTKVTEKQAETLSHLSNLAVKNDLHFKKFVTENNIPKEYKKPVELMMNYFKALNSTIANVDEDIEKLSYQPQNKINVVDVPTKYAGDVNKKQQDKIKDFLKSKGIKSDVIDK
>CP014064.2|AMG42779.1|2345696_2346080_-|hypothetical-protein
MKVRITFIILAILSTIVCLFLAAMHPTGPNTVTFEQPYLFTLNIILMVLVALPSLVLAIYDYMSFRISSAILQFLGAISWFFLSLILSLTQFTPFTLASFITSIILFISAIITLAIGGKSVDKNDSH
>CP014064.2|AMG42778.1|2345049_2345631_+|histidine-phosphatase-family-protein
MTIYLVRHGESKSNYDNKHFRSYFCGQLDVPLTDTGTKSADDLCDYFKEKQIKHVYVSDLLRTQQTFEHIFPYDIASTTTPLLRERSLGVFEGEYKDEISANPKYEKYFNDPNFKDFRHSFSQKAPEGESYEDVYQRVEHFMNHVVNEDTQKDDIVIVAHQVVIRCLMVYFNKVSREEAVDLKVENCKPYIIE
>CP014064.2|AMG42777.1|2344662_2344872_-|hypothetical-protein
MTTQSFIFMNIILLDGATQRHPFFICQILAFLFPKFPHINLLLFYPILSTFSNIIIHIDHFHANKKDDN
>CP014064.2|AMG42787.1|2353220_2354177_-|hypothetical-protein
MLTKEFAQRVELSEKQVRKIVQHLEERGYQLSKTEYRGREATDFKEEDIELFKDIADKVKQTNSYDLAFDELEKEKDFLQVIVKNDDKNLPTNQNVAQLVEDLRLEIQKMREERHLLGQMMNQVHQQQQELKELQNQLTSKIDSNSESLKAIQTSQEAIQEAQASQAKVLAESTNKVEKNAVTEDKADSKDSKVAGVNTSTDAKTDTKAENAGDGTATKVDKEDQISATEAIEKASVEQSKNENAAETSNKEATVDADAQHDAEQQVAEAHAEASKQATSNDSLEAKAENDSTASQSEMSEPKPQEEKKGFFARLFNL
>CP014064.2|AMG42788.1|2354294_2354957_-|hypothetical-protein
MEFKTIQSVKDPHYNEALKLYDTKLNLSLTEDKRIIKRSLENNKTENDYVFIVGLENDVVVSLATAHYEATTNSAFLIYLFAKDLPNHDELMTQTLHQIEHELNLLSNLVHSRSINFLMMEVPKEPADLTQDNGLIIEHRRQFLYEHQFERQTEIDYIHPTNDGHTKKVDLFLKKNIKLTKDIYGTSVKSNYILKYVFANGIAREIIYALLEEMDLRKPF
>CP014064.2|AMG42789.1|2355099_2355507_-|hypothetical-protein
MADITVVNDTGELYNVINQKKSEGYLESELTIISKSKLHLNDLHDSEISLISTSGTFSDRMTKLLTGEDGEHAVLSRYNLAPDELEKYKQLILDDKMLVVAVRDKSSHKEVQEHNSAYEEIDITHFAEASKGPKA
>CP014064.2|AMG42790.1|2356019_2356598_+|xanthine-phosphoribosyltransferase
MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVGEE
>CP014064.2|AMG42791.1|2356597_2357866_+|purine-permease
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILVLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIESTGVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEENVK
>CP014064.2|AMG42792.1|2357903_2359370_+|IMP-dehydrogenase
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSF
>CP014064.2|AMG42793.1|2359394_2360936_+|GMP-synthase-(glutamine-hydrolyzing)
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
>CP014064.2|AMG42794.1|2361048_2361585_-|hypothetical-protein
MHNKNEFNKKLKDFIGSDKRMALVKGYINEYKLTTVLRALNNSDYTKGTIHTRSIGNLKQIVDNRIIPKNITQNKIFKLSNLTLEVNLYERNTIYHGDFAIYYPVESALIIETDTPRLINHINNNPVQKIFIITTNDWSFNTLELEKIVDETIIYDLKQEDPKQYEILYKNKHGKLPY
>CP014064.2|AMG42795.1|2361976_2362681_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MSKNINQANSKLNTSNKKLKQAYSKSDSKNMKVIYMPHWLEFYSIAIHSDVTSNKKRYYKSFSRGTVVYVKLGSNIGSEFSGNHFCVILDNKDNKGKETVTIVPLSSKGNKNYLKLNESVLNLTATDLKKQIIDISSKVQALTQKYRDIDIKLSTEDKKLLSNLNQKANELYRVIGVYSKHKGKDTYVNISAITTISKRRISKINDSDPTGTIIISEDDMNEIEKQLKIKFFSN
>CP014064.2|AMG42796.1|2363079_2363352_-|hypothetical-protein
MTKERRTFSSEFKLQMVRLYKNGKLKNEIIRKYDLKPSIISNSIKQHQNTGPFNHQDNLKSDEKELIKLRKEVQHLKMEHDVLKQILKLI

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Crispr_ID: CP014064_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP014064_7

2767580-2767658

Unclear

Consensus_repeat	Method
TGTAGAATTTCTTTTCGAAATTCT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP014064_7

>merge|CP014064|7|2767580-2767658|CRISPRCasFinder
TGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCGCCAACTTGTATTGCCTGTAGAATTTCTTTTCGAAATTCT

>CP014064|7|7|2767580-2767658|CRISPRCasFinder
TGTAGAATTTCTTTTCGAAATTCT	CTGTGTTGGGGCCCCGCCAACTTGTATTGCC
TGTAGAATTTCTTTTCGAAATTCT

Protein	Signature genes	Signature genes Name	Protein_function
CP014064.2\|AMG43160.1\|2761261_2761912_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
CP014064.2\|AMG43167.1\|2770194_2771634_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
CP014064.2\|AMG43171.1\|2774429_2775425_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
CP014064.2\|AMG43165.1\|2768854_2769694_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
CP014064.2\|AMG43166.1\|2769701_2770187_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
CP014064.2\|AMG43159.1\|2760248_2761088_+\|peptidase-M23	unknown	unknown	gnl\|CDD\|226451
CP014064.2\|AMG43246.2\|2759993_2760101_+\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG43172.1\|2775535_2776480_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
CP014064.2\|AMG43161.1\|2761908_2762145_+\|DUF2198-domain-containing-protein	unknown	unknown	gnl\|CDD\|227234
CP014064.2\|AMG43168.1\|2771700_2772636_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
CP014064.2\|AMG43158.2\|2758729_2759840_+\|peptide-chain-release-factor-2	unknown	unknown	gnl\|CDD\|234799
CP014064.2\|AMG43169.2\|2772982_2773171_-\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG43156.1\|2755890_2758422_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
CP014064.2\|AMG43170.1\|2773521_2774433_+\|RNase-adaptor-protein-RapZ	unknown	unknown	gnl\|CDD\|224574
CP014064.2\|AMG43155.1\|2754904_2755477_+\|ribosomal-subunit-interface-protein	unknown	unknown	gnl\|CDD\|224461
CP014064.2\|AMG43162.1\|2762413_2764399_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
CP014064.2\|AMG43164.1\|2767916_2768849_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
CP014064.2\|AMG43163.1\|2764406_2767253_+\|excinuclease-ABC-subunit-A	unknown	unknown	gnl\|CDD\|234734
CP014064.2\|AMG43157.1\|2758463_2758568_+\|hypothetical-protein	unknown	unknown	unknown
CP014064.2\|AMG43173.1\|2777043_2777631_+\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955

Protein	Function_ID	Function_description	E-value
CP014064.2\|AMG43160.1\|2761261_2761912_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
CP014064.2\|AMG43167.1\|2770194_2771634_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.14043e-06
CP014064.2\|AMG43165.1\|2768854_2769694_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.75588e-120
CP014064.2\|AMG43168.1\|2771700_2772636_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
CP014064.2\|AMG43163.1\|2764406_2767253_+\|excinuclease-ABC-subunit-A	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
CP014064.2\|AMG43171.1\|2774429_2775425_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
CP014064.2\|AMG43172.1\|2775535_2776480_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
CP014064.2\|AMG43161.1\|2761908_2762145_+\|DUF2198-domain-containing-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
CP014064.2\|AMG43159.1\|2760248_2761088_+\|peptidase-M23	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.97111e-42
CP014064.2\|AMG43158.2\|2758729_2759840_+\|peptide-chain-release-factor-2	gnl\|CDD\|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	0
CP014064.2\|AMG43156.1\|2755890_2758422_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
CP014064.2\|AMG43170.1\|2773521_2774433_+\|RNase-adaptor-protein-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
CP014064.2\|AMG43155.1\|2754904_2755477_+\|ribosomal-subunit-interface-protein	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	1.13584e-37
CP014064.2\|AMG43162.1\|2762413_2764399_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
CP014064.2\|AMG43164.1\|2767916_2768849_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
CP014064.2\|AMG43166.1\|2769701_2770187_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
CP014064.2\|AMG43173.1\|2777043_2777631_+\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148

>CP014064.2|AMG43163.1|2764406_2767253_+|excinuclease-ABC-subunit-A
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIDVPEYRRPASDRKISIRGARSNNLKGIDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>CP014064.2|AMG43162.1|2762413_2764399_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVDGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>CP014064.2|AMG43161.1|2761908_2762145_+|DUF2198-domain-containing-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>CP014064.2|AMG43160.1|2761261_2761912_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>CP014064.2|AMG43159.1|2760248_2761088_+|peptidase-M23
MKKTLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>CP014064.2|AMG43246.2|2759993_2760101_+|hypothetical-protein
MCLLKQHMQCAFSNITYGDFQGIELIVENVLNYMV
>CP014064.2|AMG43158.2|2758729_2759840_+|peptide-chain-release-factor-2
MELSEIKRNIDKYNQDLTQIRGSLDLENKETNIQEYEEMMAEPNFWDNQTKAQDIIDKNNALKAIVNGYKTLQAEVDDMDATWDLLQEEFDEEMKEDLEQEVINFKAKVDEYELQLLLDGPHDANNAILELHPGAGGTESQDWANMLFRMYQRYCEKKGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFASCDVIPDFNNDEIEIEINPDDITVDTFRASGAGGQHINKTESAIRITHHPSGIVVNNQNERSQIKNREAAMKMLKSKLYQLKLEEQAREMAEIRGEQKEIGWGSQIRSYVFHPYSMVKDHRTNEETGKVDAVMDGDIGPFIESYLRQTMSHD
>CP014064.2|AMG43157.1|2758463_2758568_+|hypothetical-protein
MLWEESFYFTSVKYFKKCEEVVKRCYVLSFKKSV
>CP014064.2|AMG43156.1|2755890_2758422_+|preprotein-translocase-subunit-SecA
MGFLSKILDGNNKEIKQLGKLADKVIALEEKTAILTDEEIRNKTKQFQTELADIDNVKKQNDYLDKILPEAYALVREGSKRVFNMTPYKVQIMGGIAIHKGDIAEMRTGEGKTLTATMPTYLNALAGRGVHVITVNEYLSSVQSEEMAELYNFLGLTVGLNLNSKTTEEKREAYAQDITYSTNNELGFDYLRDNMVNYSEDRVMRPLHFAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKQDEDYKYDEKTKAVHLTEQGADKAERMFKVENLYDVQNVDVISHINTALRAHVTLQRDVDYMVVDGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVQIQNESKTMASITFQNYFRMYNKLAGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRNDKSDLIYISQKGKFDAVVEDVVEKHKAGQPVLLGTVAVETSEYISNLLKKRGIRHDVLNAKNHEREAEIVAGAGQKGAVTIATNMAGRGTDIKLGEGVEELGGLAVIGTERHESRRIDDQLRGRSGRQGDKGDSRFYLSLQDELMIRFGSERLQKMMSRLGLDDSTPIESKMVSRAVESAQKRVEGNNFDARKRILEYDEVLRKQREIIYNERNSIIDEEDSSQVVDAMLRSTLQRSINYYINTADDEPEYQPFIDYINDIFLQEGDITEDDIKGKDAEDIFEVVWAKIEAAYQSQKDILEEQMNEFERMILLRSIDSHWTDHIDTMDQLRQGIHLRSYAQQNPLRDYQNEGHELFDIMMQNIEEDTCKFILKSVVQVEDNIEREKTTEFGEAKHVSAEDGKEKVKPKPIVKGDQVGRNDDCPCGSGKKFKNCHGK
>CP014064.2|AMG43155.1|2754904_2755477_+|ribosomal-subunit-interface-protein
MIRFEIHGDNLTITDAIRNYIEEKIGKLERYFNDVPNAVAHVKVKTYSNSATKIEVTIPLKNVTLRAEERNDDLYAGIDLINNKLERQVRKYKTRINRKSRDRGDQEVFVAELQEMQETQVDNDAYDDNEIEIIRSKEFSLKPMDSEEAVLQMNLLGHDFFVFTDRETDGTSIVYRRKDGKYGLIQTSEQ
>CP014064.2|AMG43164.1|2767916_2768849_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>CP014064.2|AMG43165.1|2768854_2769694_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>CP014064.2|AMG43166.1|2769701_2770187_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>CP014064.2|AMG43167.1|2770194_2771634_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYQNELFVSENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>CP014064.2|AMG43168.1|2771700_2772636_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>CP014064.2|AMG43169.2|2772982_2773171_-|hypothetical-protein
MGPNTEKLDFQFLQTMQVGVWAPTKRISKRNSTGNASWGVGPNTEAYDKSAYDNVQVGVVQR
>CP014064.2|AMG43170.1|2773521_2774433_+|RNase-adaptor-protein-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>CP014064.2|AMG43171.1|2774429_2775425_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>CP014064.2|AMG43172.1|2775535_2776480_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>CP014064.2|AMG43173.1|2777043_2777631_+|ATP-dependent-Clp-protease-proteolytic-subunit
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK

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Crispr_ID: CP014064_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP014064_8

2773035-2773304

Unclear

Consensus_repeat	Method
TTCTCTGTGTTGGGGCCCACACCCCAACTNGCATTG	CRT

4 spacers

The CRISPR arrays of CP014064_8

>merge|CP014064|8|2773035-2773304|CRT
GCTTCTGTGTTGGGGCCCACACCCCAACTCGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTTTGTTGGGGCCCACACCCCAACTTGCATTGTCTGTAGAAATTGGAAATCCAATTTCTCTGTGTTGGGGCCCACACCCCAACTCGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCACACCCCAACTTGCATTGTCTGTAGAAATTGGAAATCCAATTTCTCTGTGTTGGGGCCCCTGACTAGAGTTGAAAAA

>CP014064|8|1|2773035-2773304|CRT
GCTTCTGTGTTGGGGCCCACACCCCAACTCGCATTG	CCTGTAGAATTTCTTTTCGAAA
TTCTCTTTGTTGGGGCCCACACCCCAACTTGCATTG	TCTGTAGAAATTGGAAATCCAAT
TTCTCTGTGTTGGGGCCCACACCCCAACTCGCATTG	CCTGTAGAATTTCTTTTCGAAA
TTCTCTGTGTTGGGGCCCACACCCCAACTTGCATTG	TCTGTAGAAATTGGAAATCCAAT
TTCTCTGTGTTGGGGCCCCTGACTAGAGTTGAAAAA

Protein	Signature genes	Signature genes Name	Protein_function
CP014064.2\|AMG43160.1\|2761261_2761912_+\|HD-domain-containing-protein	unknown	unknown	gnl\|CDD\|378993
CP014064.2\|AMG43168.1\|2771700_2772636_+\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
CP014064.2\|AMG43174.1\|2777873_2778776_-\|epimerase	unknown	unknown	gnl\|CDD\|224015
CP014064.2\|AMG43165.1\|2768854_2769694_+\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|183527
CP014064.2\|AMG43172.1\|2775535_2776480_+\|DNA-binding-protein-WhiA	unknown	unknown	gnl\|CDD\|273194
CP014064.2\|AMG43177.1\|2781986_2782997_+\|aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|273675
CP014064.2\|AMG43163.1\|2764406_2767253_+\|excinuclease-ABC-subunit-A	unknown	unknown	gnl\|CDD\|234734
CP014064.2\|AMG43171.1\|2774429_2775425_+\|YvcK-family-protein	unknown	unknown	gnl\|CDD\|211689
CP014064.2\|AMG43161.1\|2761908_2762145_+\|DUF2198-domain-containing-protein	unknown	unknown	gnl\|CDD\|227234
CP014064.2\|AMG43167.1\|2770194_2771634_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276808
CP014064.2\|AMG43166.1\|2769701_2770187_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|100053
CP014064.2\|AMG43175.1\|2779478_2780108_+\|DUF4887-domain-containing-protein	unknown	unknown	gnl\|CDD\|234750
CP014064.2\|AMG43179.1\|2784447_2785209_+\|triose-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234589
CP014064.2\|AMG43176.1\|2780920_2781934_+\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263
CP014064.2\|AMG43170.1\|2773521_2774433_+\|RNase-adaptor-protein-RapZ	unknown	unknown	gnl\|CDD\|224574
CP014064.2\|AMG43162.1\|2762413_2764399_+\|excinuclease-ABC-subunit-UvrB	unknown	unknown	gnl\|CDD\|235395
CP014064.2\|AMG43164.1\|2767916_2768849_+\|HPr-kinase/phosphorylase	unknown	unknown	gnl\|CDD\|235459
CP014064.2\|AMG43159.1\|2760248_2761088_+\|peptidase-M23	unknown	unknown	gnl\|CDD\|226451
CP014064.2\|AMG43173.1\|2777043_2777631_+\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
CP014064.2\|AMG43178.1\|2783135_2784326_+\|phosphoglycerate-kinase	unknown	unknown	gnl\|CDD\|234613

Protein	Function_ID	Function_description	E-value
CP014064.2\|AMG43160.1\|2761261_2761912_+\|HD-domain-containing-protein	gnl\|CDD\|378993	pfam12917, HD_2, HD containing hydrolase-like enzyme. This is a family of bacterial and archaeal hydrolases.	6.51021e-58
CP014064.2\|AMG43168.1\|2771700_2772636_+\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	4.19425e-154
CP014064.2\|AMG43174.1\|2777873_2778776_-\|epimerase	gnl\|CDD\|224015	COG1090, COG1090, Predicted nucleoside-diphosphate sugar epimerase [General function prediction only].	6.73087e-155
CP014064.2\|AMG43165.1\|2768854_2769694_+\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|183527	PRK12437, PRK12437, prolipoprotein diacylglyceryl transferase; Reviewed.	1.75588e-120
CP014064.2\|AMG43172.1\|2775535_2776480_+\|DNA-binding-protein-WhiA	gnl\|CDD\|273194	TIGR00647, DNA_bind_WhiA, DNA-binding protein WhiA. This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation. [Cellular processes, Cell division].	7.40812e-153
CP014064.2\|AMG43177.1\|2781986_2782997_+\|aldehyde-dehydrogenase	gnl\|CDD\|273675	TIGR01534, Glyceraldehyde-3-phosphate_dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase, type I. This model represents glyceraldehyde-3-phosphate dehydrogenase (GAPDH), the enzyme responsible for the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. Forms exist which utilize NAD (EC 1.2.1.12), NADP (EC 1.2.1.13) or either (1.2.1.59). In some species, NAD- and NADP- utilizing forms exist, generally being responsible for reactions in the anabolic and catabolic directions respectively. Two Pfam models cover the two functional domains of this protein; pfam00044 represents the N-terminal NAD(P)-binding domain and pfam02800 represents the C-terminal catalytic domain. An additional form of gap gene is found in gamma proteobacteria and is responsible for the conversion of erythrose-4-phosphate (E4P) to 4-phospho-erythronate in the biosynthesis of pyridoxine. This pathway of pyridoxine biosynthesis appears to be limited, however, to a relatively small number of bacterial species although it is prevalent among the gamma-proteobacteria. This enzyme is described by TIGR001532. These sequences generally score between trusted and noise to this GAPDH model due to the close evolutionary relationship. There exists the possiblity that some forms of GAPDH may be bifunctional and act on E4P in species which make pyridoxine and via hydroxythreonine and lack a separate E4PDH enzyme (for instance, the GAPDH from Bacillus stearothermophilus has been shown to posess a limited E4PD activity as well as a robust GAPDH activity). There are a great number of sequences in the databases which score between trusted and noise to this model, nearly all of them due to fragmentary sequences. It seems that study of this gene has been carried out in many species utilizing PCR probes which exclude the extreme ends of the consenses used to define this model. The noise level is set relative not to E4PD, but the next closest outliers, the class II GAPDH's (found in archaea, TIGR01546) and aspartate semialdehyde dehydrogenase (ASADH, TIGR01296) both of which have highest-scoring hits around -225 to the prior model. [Energy metabolism, Glycolysis/gluconeogenesis].	0
CP014064.2\|AMG43163.1\|2764406_2767253_+\|excinuclease-ABC-subunit-A	gnl\|CDD\|234734	PRK00349, uvrA, excinuclease ABC subunit UvrA.	0
CP014064.2\|AMG43171.1\|2774429_2775425_+\|YvcK-family-protein	gnl\|CDD\|211689	TIGR01826, Putative_gluconeogenesis_factor, conserved hypothetical protein, cofD-related. This model represents a subfamily of conserved hypothetical proteins that forms a sister group to the family of CofD, (TIGR01819), LPPG:Fo 2-phospho-L-lactate transferase, an enzyme of cytochrome F420 biosynthesis. Both this family and TIGR01819 are within the scope of the pfam01933. [Hypothetical proteins, Conserved].	5.06652e-172
CP014064.2\|AMG43161.1\|2761908_2762145_+\|DUF2198-domain-containing-protein	gnl\|CDD\|227234	COG4897, CsbA, Uncharacterized protein conserved in bacteria [Function unknown].	4.73465e-34
CP014064.2\|AMG43167.1\|2770194_2771634_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|276808	sd00008, TPR_YbbN, C-terminal Tetratricopeptide repeat (TPR) region of YbbN and similar motifs. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. YbbN is a thioredoxin-like protein containing two tandem TPR repeats at the C-terminus, separated by two alpha helices. Its N-terminal thioredoxin-like domain is not a functional oxidoreductase. It functions in heat stress response and DNA synthesis as a chaperone or co-chaperone.	4.14043e-06
CP014064.2\|AMG43166.1\|2769701_2770187_+\|acetyltransferase	gnl\|CDD\|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	4.85181e-30
CP014064.2\|AMG43175.1\|2779478_2780108_+\|DUF4887-domain-containing-protein	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	5.80381e-05
CP014064.2\|AMG43179.1\|2784447_2785209_+\|triose-phosphate-isomerase	gnl\|CDD\|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	2.84083e-146
CP014064.2\|AMG43176.1\|2780920_2781934_+\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	1.39665e-92
CP014064.2\|AMG43170.1\|2773521_2774433_+\|RNase-adaptor-protein-RapZ	gnl\|CDD\|224574	COG1660, COG1660, Predicted P-loop-containing kinase [General function prediction only].	4.97899e-170
CP014064.2\|AMG43162.1\|2762413_2764399_+\|excinuclease-ABC-subunit-UvrB	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
CP014064.2\|AMG43164.1\|2767916_2768849_+\|HPr-kinase/phosphorylase	gnl\|CDD\|235459	PRK05428, PRK05428, HPr kinase/phosphorylase; Provisional.	1.22623e-170
CP014064.2\|AMG43159.1\|2760248_2761088_+\|peptidase-M23	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	1.97111e-42
CP014064.2\|AMG43173.1\|2777043_2777631_+\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	4.59321e-148
CP014064.2\|AMG43178.1\|2783135_2784326_+\|phosphoglycerate-kinase	gnl\|CDD\|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0

>CP014064.2|AMG43168.1|2771700_2772636_+|thioredoxin-disulfide-reductase
MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPDLSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVINFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQDRAFKNDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPFKDLGITNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLNDQA
>CP014064.2|AMG43167.1|2770194_2771634_+|tetratricopeptide-repeat-protein
MAQKNNNVIPMTFDDAFYRKMAKQKFKQREYKRAAEYFEKVLELSPDDLEIQIDYAQCLVQLGIAKKAEHLFYDNIIYNRHLEDSFYELSQLNIEVNEPNKAFLFGINYVIVSDDQDYRDELDQMFDVKYQSEEQIELEAQLFVVQILFQYLFSQGRLKDAKNYVLHQPQEVQDHRVVRNLLAMCYLYLGEYDTAKALYEALLQEDSTDIYALCHYTLLLYNTKENEQYQKYLKILNKVVPMNDDESFKLGIVLSYLKQYRASQQLLYPLYKKGKFLSIQMYNALAYNYYYLGEEDESHYYWDKLKQISKVEIGHAPWVIENSKEVFDQHILPLLQSDDSHYRLYGIFLLDQLNGKEIVMTESIWQVLENLNNYEKLYLTYLVQGLTLNKLDFIHRGLLTLYQNELFVSENDLMVAWINQGELIIAEKVDLTDVEPYIGAFIYLYFKNQPRNVTKKQITTWLGITQYKLNKMIEFLLSI
>CP014064.2|AMG43166.1|2769701_2770187_+|acetyltransferase
MRKFLSKTHHHTNPLWRVYRLVKFSKVFKNVIIIEFSKFIPSMVLKRHIYKQLLNINIGNQSSIAYKVMLDIFYPELITIGSNSVIGYNVTILTHEALVDEFRYGPVTIGSNTLIGANATILPGITIGDNVKVAAGTVVSKDIPDNGFAYGNPMYIKMIRR
>CP014064.2|AMG43165.1|2768854_2769694_+|prolipoprotein-diacylglyceryl-transferase
MGIVFNYIDPVAFNLGPLSVRWYGIIIAVGILLGYFVAQRALVKAGLHKDTLVDIIFYSALFGFIAARIYFVIFQWPYYAENPSEIIKIWHGGIAIHGGLIGGFIAGVIVCKVKNLNPFQIGDIVAPSIILAQGIGRWGNFMNHEAHGGPVSRAFLEQLHLPNFIIENMYINGQYYHPTFLYESIWDVAGFIILVNIRKHLKLGETFFLYLTWYSIGRFFIEGLRTDSLMLTSNIRVAQLVSILLILISISLIVYRRIKYNPPLYSKVGALPWPTKKVK
>CP014064.2|AMG43164.1|2767916_2768849_+|HPr-kinase/phosphorylase
MLTTEKLVETLKLDLIAGEEGLSKPIKNADISRPGLEMAGYFSHYASDRIQLLGTTELSFYNLLPDKDRAGRMRKLCRPETPAIIVTRGLQPPEELVEAAKELNTPLIVAKDATTSLMSRLTTFLEHALAKTTSLHGVLVDVYGVGVLITGDSGIGKSETALELVKRGHRLVADDNVEIRQINKDELIGKPPKLIEHLLEIRGLGIINVMTLFGAGSILTEKRIRLNINLENWNKQKLYDRVGLNEETLSILDTEITKKTIPVRPGRNVAVIIEVAAMNYRLNIMGINTAEEFSERLNEEIIKNSHKSEE
>CP014064.2|AMG43163.1|2764406_2767253_+|excinuclease-ABC-subunit-A
MKEPSIVVKGARAHNLKDIDIELPKNKLIVMTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDTIEGLSPAISIDQKTTSKNPRSTVATVTEIYDYIRLLYARVGKPYCPNHNIEIESQTVQQMVDRIMELEARTKIQLLAPVIAHRKGSHEKLIEDIGKKGYVRLRIDGEIVDVNDVPTLDKNKNHTIEVVVDRLVVKDGIETRLADSIETALELSEGQLTVDVIDGEDLKFSESHACPICGFSIGELEPRMFSFNSPFGACPTCDGLGQKLTVDVDLVVPDKDKTLNEGAIEPWIPTSSDFYPTLLKRVCEVYKINMDKPFKKLTERQRDILLYGSGDKEIEFTFTQRQGGTRKRTMVFEGVVPNISRRFHESPSEYTREMMSKYMTELPCETCHGKRLSREALSVYVGGLNIGEVVEYSISQALNYYKNIDLSEQDQAIANQILKEIISRLTFLNNVGLEYLTLNRASGTLSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLINTLKEMRDLGNTLIVVEHDDDTMRAADYLVDIGPGAGEHGGQIVSSGTPQKVMKDKKSLTGQYLSGKKRIDVPEYRRPASDRKISIRGARSNNLKGIDVDIPLSIMTVVTGVSGSGKSSLVNEVLYKSLAQKINKSKVKPGLYDKIEGIDQLDKIIDIDQSPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKIRGYQKGRFSFNVKGGRCEACKGDGIIKIEMHFLPDVYVPCEVCDGKRYNRETLEVTYKGKNIADILEMTVEEATQFFENIPKIKRKLQTLVDVGLGYVTLGQQATTLSGGEAQRVKLASELHKRSTGKSIYILDEPTTGLHVDDISRLLKVLNRLVENGDTVVIIEHNLDVIKTADYIIDLGPEGGSGGGTIVATGTPEDIAQTKSSYTGKYLKEVLERDKQNTEDK
>CP014064.2|AMG43162.1|2762413_2764399_+|excinuclease-ABC-subunit-UvrB
MVEHYPFKIHSDFEPQGDQPQAIKEIVDGIKAGKRHQTLLGATGTGKTFTMSNVIKEVGKPTLIIAHNKTLAGQLYSEFKEFFPENRVEYFVSYYDYYQPEAYVPSTDTFIEKDASINDEIDQLRHSATSALFERDDVIIIASVSCIYGLGNPEEYKDLVVSVRVGMEMDRSELLRKLVDVQYTRNDIDFQRGTFRVRGDVVEIFPASKEELCIRVEFFGDEIDRIREVNYLTGEVLKEREHFAIFPASHFVTREEKLKVAIERIEKELEERLKELRDENKLLEAQRLEQRTNYDLEMMREMGFCSGIENYSVHLTLRPLGSTPYTLLDYFGDDWLVMIDESHVTLPQVRGMYNGDRARKQVLVDHGFRLPSALDNRPLKFEEFEEKTKQLVYVSATPGPYEIEHTDKMVEQIIRPTGLLDPKIEVRPTENQIDDLLSEIQTRVERNERVLVTTLTKKMSEDLTTYMKEAGIKVNYLHSEIKTLERIEIIRDLRMGTYDVIVGINLLREGIDIPEVSLVVILDADKEGFLRSNRSLIQTIGRAARNDKGEVIMYADKMTDSMKYAIDETQRRREIQMKHNEKHGITPKTINKKIHDLISATVENDENNDKAQTVIPKKMTKKERQKTIDNIEKEMKQAAKDLDFEKATELRDMLFELKAEG
>CP014064.2|AMG43161.1|2761908_2762145_+|DUF2198-domain-containing-protein
MIWYFSAAFFPCVLVVLFSVITRSKWVGTILTLILIGASIYKEYFHNEWIIFIDVVSLLAGYLIIDQLEFHKHQDEDR
>CP014064.2|AMG43160.1|2761261_2761912_+|HD-domain-containing-protein
MGVHQYFKRLSDMERLIRLPGKFKYFEHNVAAHSFKVTKIAQYLATVEEYHGRKINWKSLYEKALNHDFAEVFTGDIKTPVKYASSELKKLFSQVEEEMVETFIEEEIPLQYRDVYKQRLQEGKDDSLEGQILSVADKIDLLYETFGEIQKRNPEELFFEIYEMSLETIIQFDHLASVQDFINNIIPEMLTENFIPRTELRETTMNILNKRKEENE
>CP014064.2|AMG43159.1|2760248_2761088_+|peptidase-M23
MKKTLTVTVSSVLAFLALNNAAHAQQHGTQVKTPVQHNYVSNVQAQTQSPTTYTVVAGDSLYKIALEHHLTLNQLYSYNPGVTPLIFPGDVISLVPQNKVKQTKAVKSPVRKASQAKKVVKQPVQQASKKVVVKQAPKQAVAKTVNVAYKPAQVQKSVPTVPVAHNYNKSVANRGNLYAYGNCTYYAFDRRAQLGRSIGSLWGNANNWNYAAKVAGFKVDKTPEVGAIFQTAAGPYGHVGVVESVNPNGTITVSEMNYAGFNVKSSRTILNPGKYNYIH
>CP014064.2|AMG43170.1|2773521_2774433_+|RNase-adaptor-protein-RapZ
MDNNEKEKSKSELLVVTGLSGAGKSLVIQCLEDMGYFCVDNLPPVLLPKFVELMEQGNPSLRKVAIAIDLRGKELFNSLVAVVDKVKSESDVIIDVMFLEASTEKLISRYKETRRAHPLMEQGKRSLINAINDEREHLSQIRSIANFVIDTTKLSPKELKERIRRYYEDEEFETFTINVTSFGFKHGIQMDADLVFDVRFLPNPYYVVDLRPLTGLDKDVYNYVMKWKETEIFFEKLTDLLDFMIPGYKKEGKSQLVIAIGCTGGQHRSVALAERLGNYLNEVFEYNVYVHHRDAHIESGEKK
>CP014064.2|AMG43171.1|2774429_2775425_+|YvcK-family-protein
MRQIKVVLIGGGTGLSVMARGLREFPIDITAIVTVADNGGSTGKIRDEMDIPAPGDIRNVIAALSDSESVLSQLFQYRFEENQISGHSLGNLLIAGMTNITNDFGHAIKALSKILNIKGRVIPSTNTSVQLNAVMEDGEIVFGETNIPKKHKKIDRVFLEPNDVQPMEEAIDALREADLIVLGPGSLYTSVISNLCVNGISDALIHSDAPKLYVSNVMTQPGETDGYSVKDHIDAIHRQAGQPFIDYVICSTQTFNAQVLKKYEEKHSKPVEVNKAELEKESINVKTSSNLVEISENHLVRHNTKVLSTMIYDIALELISTIPFVPSDKRK
>CP014064.2|AMG43172.1|2775535_2776480_+|DNA-binding-protein-WhiA
MSFASEMKNELTRIDVDEMNAKAELSALIRMNGALSLSNQQFVINVQTENATTARRIYSLIKRVFNVEVEILVRKKMKLKKNNIYICRTKMKAKEILDELGILKDGIFTHEIDHSMIQDDEMRRSYLRGAFLAGGSVNNPETSSYHLEIFSQNESHAEGLTKLMNSYELNAKHLERKKGSITYLKEAEKISDFLSLIGGYQALLKFEDVRIVRDMRNSVNRLVNCETANLNKTVSAAMKQVESIKLIDKEIGIENLPDRLREIARIRVEHQEISLKELGEMVSTGPISKSGVNHRLRKLNDLADKIRNGEQIEL
>CP014064.2|AMG43173.1|2777043_2777631_+|ATP-dependent-Clp-protease-proteolytic-subunit
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
>CP014064.2|AMG43174.1|2777873_2778776_-|epimerase
MKQYLITGGTGMVGSQLVNEIKKSDSHITILTRHDQISNDKKISYVNWAKSGWEHKVPQNIDVVINLAGATLNKRWTPEYKQTLMLSRIQSTQALYELFKSRNKAPKVLFNASATGYYPPDLFMSYTEVYKTLPFDFLSDIVYQWERFAQQFEQLGTRVVIGRFGMILSNEGGALQTMKLPYKYYIGGKLGSGQQWYSWIHINDLIQAILFLINNESASGPFNLTAPIPERQNLFGYTLARAMHKPHETWAPSLAMRLILGQMSTVVLDTQKVLPNKIQALGFQFKYSNLKMALEDLIKE
>CP014064.2|AMG43175.1|2779478_2780108_+|DUF4887-domain-containing-protein
MSNQNYDYNKNEDGSKKKMSTTAKVVSIATVLLLLGGLVFAIFAYVDHSNKAKERMLNEQKQEQKEKRQKENAEKERKKKQQEEKEQNELDSQANQYQQLPQQNQYQYVPPQQQAPTKQRPAKEENDDKASKDESKDKDDNASQDKSDDNQKKTDDNKQPAQPKPQPQQPTPKPNNNQQNNQSNQQAKPQAPQQNSQSTTNKQNNANDK
>CP014064.2|AMG43176.1|2780920_2781934_+|sugar-binding-transcriptional-regulator
MKDLLQAQQKLIPDLIDKMYKRFSILTTISKNQPVGRRSLSEHMDMTERVLRSETDMLKKQDLIKVKPTGMEITAEGEQLISQLKGYFDIYADDNRLSEGIKNKFQIKEVHVVPGDADNSQSVKTELGRQAGQLLEGILQEDAIVAVTGGSTMACVSEAIHLLPYNVFFVPARGGLGENVVFQANTIAASMAQQAGGYYTTMYVPDNVSETTYNTLLLEPSVINTLDKIKQANVILHGIGDALKMAHRRQSPEKVIEQLQHHQAVGEAFGYYFDTQGQIVHKVKTIGLQLEDLESKDFIFAVAGGKSKGEAIKAYLTIAPKNTVLITDEAAAKIILE
>CP014064.2|AMG43177.1|2781986_2782997_+|aldehyde-dehydrogenase
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
>CP014064.2|AMG43178.1|2783135_2784326_+|phosphoglycerate-kinase
MAKKIVSDLDLKGKTVLVRADFNVPLKDGEITNDNRIVQALPTIQYIIEQGGKIVLFSHLGKVKEESDKAKLTLRPVAEDLSKKLDKEVVFVPETRGEKLEAAIKDLKEGDVLLVENTRYEDLDGKKESKNDPELGKYWASLGDVFVNDAFGTAHREHASNVGISTHLETAAGFLMDKEIKFIGGVVNDPHKPVVAILGGAKVSDKINVIKNLVNIADKIIIGGGMAYTFLKAQGKEIGISLLEEDKIDFAKDLLEKHGDKIVLPVDTKVAKEFSNDAKITVVPSDSIPADQEGMDIGPNTVKLFADELEGAHTVVWNGPMGVFEFSNFAQGTIGVCKAIANLKDAITIIGGGDSAAAAISLGFENDFTHISTGGGASLEYLEGKELPGIKAINNK
>CP014064.2|AMG43179.1|2784447_2785209_+|triose-phosphate-isomerase
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKVEDFVQLLEGAK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP014064_2	2.1\|1248253\|34\|CP014064\|CRISPRCasFinder	1248253-1248286	34	CP014064.2	2767579-2767612	0	1.0
CP014064_5	5.1\|2115370\|33\|CP014064\|CRISPRCasFinder	2115370-2115402	33	CP014064.2	550737-550769	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	31337-31358	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	550640-550661	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	639191-639212	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	820721-820742	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	835255-835276	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	1147067-1147088	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	2115331-2115352	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	2238467-2238488	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	2238577-2238598	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	2601099-2601120	0	1.0
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	2725625-2725646	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	31337-31358	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	550640-550661	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	639191-639212	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	820721-820742	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	835255-835276	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	1147067-1147088	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	2115331-2115352	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	2238467-2238488	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	2238577-2238598	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	2601099-2601120	0	1.0
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	2725625-2725646	0	1.0
CP014064_1	1.1\|31288\|34\|CP014064\|CRISPRCasFinder	31288-31321	34	CP014064.2	550736-550769	1	0.971
CP014064_2	2.1\|1248253\|34\|CP014064\|CRISPRCasFinder	1248253-1248286	34	CP014064.2	337307-337340	1	0.971
CP014064_2	2.1\|1248253\|34\|CP014064\|CRISPRCasFinder	1248253-1248286	34	CP014064.2	940610-940643	1	0.971
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	2780323-2780353	1	0.968
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	2780379-2780409	1	0.968
CP014064_7	7.1\|2767604\|31\|CP014064\|CRISPRCasFinder	2767604-2767634	31	CP014064.2	2238542-2238572	1	0.968
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	144827-144848	1	0.955
CP014064_8	8.1\|2773071\|22\|CP014064\|CRT	2773071-2773092	22	CP014064.2	854982-855003	1	0.955
CP014064_8	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	CP014064.2	550756-550778	1	0.957
CP014064_8	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	CP014064.2	1147125-1147147	1	0.957
CP014064_8	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	CP014064.2	1486496-1486518	1	0.957
CP014064_8	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	CP014064.2	2726575-2726597	1	0.957
CP014064_8	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	CP014064.2	2726909-2726931	1	0.957
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	144827-144848	1	0.955
CP014064_8	8.3\|2773188\|22\|CP014064\|CRT	2773188-2773209	22	CP014064.2	854982-855003	1	0.955
CP014064_8	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	CP014064.2	550756-550778	1	0.957
CP014064_8	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	CP014064.2	1147125-1147147	1	0.957
CP014064_8	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	CP014064.2	1486496-1486518	1	0.957
CP014064_8	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	CP014064.2	2726575-2726597	1	0.957
CP014064_8	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	CP014064.2	2726909-2726931	1	0.957
CP014064_2	2.1\|1248253\|34\|CP014064\|CRISPRCasFinder	1248253-1248286	34	CP014064.2	555110-555143	2	0.941
CP014064_2	2.1\|1248253\|34\|CP014064\|CRISPRCasFinder	1248253-1248286	34	CP014064.2	1939000-1939033	2	0.941
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	31600-31630	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	240318-240348	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	343076-343106	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	550695-550725	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	639127-639157	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	639243-639273	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	835309-835339	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	1486549-1486579	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	1663700-1663730	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	2016683-2016713	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	2314365-2314395	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	2601154-2601184	2	0.935
CP014064_4	4.1\|1498870\|31\|CP014064\|CRISPRCasFinder	1498870-1498900	31	CP014064.2	2780435-2780465	2	0.935
CP014064_5	5.1\|2115370\|33\|CP014064\|CRISPRCasFinder	2115370-2115402	33	CP014064.2	639083-639115	2	0.939
CP014064_7	7.1\|2767604\|31\|CP014064\|CRISPRCasFinder	2767604-2767634	31	CP014064.2	855127-855157	2	0.935
CP014064_7	7.1\|2767604\|31\|CP014064\|CRISPRCasFinder	2767604-2767634	31	CP014064.2	2238487-2238517	2	0.935
CP014064_8	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	CP014064.2	639074-639096	2	0.913
CP014064_8	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	CP014064.2	1248310-1248332	2	0.913
CP014064_8	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	CP014064.2	639074-639096	2	0.913
CP014064_8	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	CP014064.2	1248310-1248332	2	0.913

1. spacer 2.1|1248253|34|CP014064|CRISPRCasFinder matches to position: 2767579-2767612, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

2. spacer 5.1|2115370|33|CP014064|CRISPRCasFinder matches to position: 550737-550769, mismatch: 0, identity: 1.0

tgggccccaacaaagagaaattggattcccaat	CRISPR spacer
tgggccccaacaaagagaaattggattcccaat	Protospacer
*********************************

3. spacer 8.1|2773071|22|CP014064|CRT matches to position: 31337-31358, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

4. spacer 8.1|2773071|22|CP014064|CRT matches to position: 550640-550661, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

5. spacer 8.1|2773071|22|CP014064|CRT matches to position: 639191-639212, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

6. spacer 8.1|2773071|22|CP014064|CRT matches to position: 820721-820742, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

7. spacer 8.1|2773071|22|CP014064|CRT matches to position: 835255-835276, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

8. spacer 8.1|2773071|22|CP014064|CRT matches to position: 1147067-1147088, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

9. spacer 8.1|2773071|22|CP014064|CRT matches to position: 2115331-2115352, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

10. spacer 8.1|2773071|22|CP014064|CRT matches to position: 2238467-2238488, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

11. spacer 8.1|2773071|22|CP014064|CRT matches to position: 2238577-2238598, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

12. spacer 8.1|2773071|22|CP014064|CRT matches to position: 2601099-2601120, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

13. spacer 8.1|2773071|22|CP014064|CRT matches to position: 2725625-2725646, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

14. spacer 8.3|2773188|22|CP014064|CRT matches to position: 31337-31358, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

15. spacer 8.3|2773188|22|CP014064|CRT matches to position: 550640-550661, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

16. spacer 8.3|2773188|22|CP014064|CRT matches to position: 639191-639212, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

17. spacer 8.3|2773188|22|CP014064|CRT matches to position: 820721-820742, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

18. spacer 8.3|2773188|22|CP014064|CRT matches to position: 835255-835276, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

19. spacer 8.3|2773188|22|CP014064|CRT matches to position: 1147067-1147088, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

20. spacer 8.3|2773188|22|CP014064|CRT matches to position: 2115331-2115352, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

21. spacer 8.3|2773188|22|CP014064|CRT matches to position: 2238467-2238488, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

22. spacer 8.3|2773188|22|CP014064|CRT matches to position: 2238577-2238598, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

23. spacer 8.3|2773188|22|CP014064|CRT matches to position: 2601099-2601120, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

24. spacer 8.3|2773188|22|CP014064|CRT matches to position: 2725625-2725646, mismatch: 0, identity: 1.0

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttcgaaa	Protospacer
**********************

25. spacer 1.1|31288|34|CP014064|CRISPRCasFinder matches to position: 550736-550769, mismatch: 1, identity: 0.971

attgagaatccaatttctctttgttggggcccat	CRISPR spacer
attgggaatccaatttctctttgttggggcccat	Protospacer
****.*****************************

26. spacer 2.1|1248253|34|CP014064|CRISPRCasFinder matches to position: 337307-337340, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatatcttttcgaaattctctgtgttgg	Protospacer
********* ************************

27. spacer 2.1|1248253|34|CP014064|CRISPRCasFinder matches to position: 940610-940643, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctttgtgttgg	Protospacer
*************************.********

28. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 2780323-2780353, mismatch: 1, identity: 0.968

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgtcagct	Protospacer
***********************.*******

29. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 2780379-2780409, mismatch: 1, identity: 0.968

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgtcagct	Protospacer
***********************.*******

30. spacer 7.1|2767604|31|CP014064|CRISPRCasFinder matches to position: 2238542-2238572, mismatch: 1, identity: 0.968

ctgtgttggggccccgccaacttgtattgcc	CRISPR spacer
ctgtgttggggccccgccaacttgcattgcc	Protospacer
************************.******

31. spacer 8.1|2773071|22|CP014064|CRT matches to position: 144827-144848, mismatch: 1, identity: 0.955

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttagaaa	Protospacer
***************** ****

32. spacer 8.1|2773071|22|CP014064|CRT matches to position: 854982-855003, mismatch: 1, identity: 0.955

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttctttacgaaa	Protospacer
**************** *****

33. spacer 8.2|2773129|23|CP014064|CRT matches to position: 550756-550778, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

34. spacer 8.2|2773129|23|CP014064|CRT matches to position: 1147125-1147147, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

35. spacer 8.2|2773129|23|CP014064|CRT matches to position: 1486496-1486518, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

36. spacer 8.2|2773129|23|CP014064|CRT matches to position: 2726575-2726597, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

37. spacer 8.2|2773129|23|CP014064|CRT matches to position: 2726909-2726931, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

38. spacer 8.3|2773188|22|CP014064|CRT matches to position: 144827-144848, mismatch: 1, identity: 0.955

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttcttttagaaa	Protospacer
***************** ****

39. spacer 8.3|2773188|22|CP014064|CRT matches to position: 854982-855003, mismatch: 1, identity: 0.955

cctgtagaatttcttttcgaaa	CRISPR spacer
cctgtagaatttctttacgaaa	Protospacer
**************** *****

40. spacer 8.4|2773246|23|CP014064|CRT matches to position: 550756-550778, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

41. spacer 8.4|2773246|23|CP014064|CRT matches to position: 1147125-1147147, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

42. spacer 8.4|2773246|23|CP014064|CRT matches to position: 1486496-1486518, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

43. spacer 8.4|2773246|23|CP014064|CRT matches to position: 2726575-2726597, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

44. spacer 8.4|2773246|23|CP014064|CRT matches to position: 2726909-2726931, mismatch: 1, identity: 0.957

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatccaat	Protospacer
**************.********

45. spacer 2.1|1248253|34|CP014064|CRISPRCasFinder matches to position: 555110-555143, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtggaatttcttatcgaaattctctgtgttgg	Protospacer
****.********* *******************

46. spacer 2.1|1248253|34|CP014064|CRISPRCasFinder matches to position: 1939000-1939033, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctttttgttgg	Protospacer
*************************.* ******

47. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 31600-31630, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

48. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 240318-240348, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

49. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 343076-343106, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

50. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 550695-550725, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

51. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 639127-639157, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

52. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 639243-639273, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

53. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 835309-835339, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

54. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 1486549-1486579, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

55. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 1663700-1663730, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

56. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 2016683-2016713, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

57. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 2314365-2314395, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

58. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 2601154-2601184, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
**********************..*******

59. spacer 4.1|1498870|31|CP014064|CRISPRCasFinder matches to position: 2780435-2780465, mismatch: 2, identity: 0.935

cacattattgtaagctgactttctgtcagct	CRISPR spacer
cacattattgtaagctgactttccgccagct	Protospacer
***********************.*.*****

60. spacer 5.1|2115370|33|CP014064|CRISPRCasFinder matches to position: 639083-639115, mismatch: 2, identity: 0.939

tgggccccaacaaagagaaattggattcccaat	CRISPR spacer
tggaccccaacaaagagaaattgtattcccaat	Protospacer
***.******************* *********

61. spacer 7.1|2767604|31|CP014064|CRISPRCasFinder matches to position: 855127-855157, mismatch: 2, identity: 0.935

ctgtgttggggccccgccaacttgtattgcc	CRISPR spacer
ctgtgttggggccccgccaacttccattgcc	Protospacer
*********************** .******

62. spacer 7.1|2767604|31|CP014064|CRISPRCasFinder matches to position: 2238487-2238517, mismatch: 2, identity: 0.935

ctgtgttggggccccgccaacttgtattgcc	CRISPR spacer
ctgtgttggggccccgccaacttgcattacc	Protospacer
************************.***.**

63. spacer 8.2|2773129|23|CP014064|CRT matches to position: 639074-639096, mismatch: 2, identity: 0.913

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatacaat	Protospacer
**************.*** ****

64. spacer 8.2|2773129|23|CP014064|CRT matches to position: 1248310-1248332, mismatch: 2, identity: 0.913

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

65. spacer 8.4|2773246|23|CP014064|CRT matches to position: 639074-639096, mismatch: 2, identity: 0.913

tctgtagaaattggaaatccaat	CRISPR spacer
tctgtagaaattgggaatacaat	Protospacer
**************.*** ****

66. spacer 8.4|2773246|23|CP014064|CRT matches to position: 1248310-1248332, mismatch: 2, identity: 0.913

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP014064_8	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	AP014226	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S44-C3, * SEQUENCING IN PROGRESS *	28490-28512	3	0.87
CP014064_8	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	AP014225	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S41-C89, * SEQUENCING IN PROGRESS *	24653-24675	3	0.87
CP014064_8	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	AP014226	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S44-C3, * SEQUENCING IN PROGRESS *	28490-28512	3	0.87
CP014064_8	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	AP014225	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S41-C89, * SEQUENCING IN PROGRESS *	24653-24675	3	0.87

1. spacer 8.2|2773129|23|CP014064|CRT matches to AP014226 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S44-C3, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 3, identity: 0.87

tctgtagaaattggaaatccaat	CRISPR spacer
actgtagaaaatggaaatccaac	Protospacer
 ********* ***********.

2. spacer 8.2|2773129|23|CP014064|CRT matches to AP014225 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S41-C89, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 3, identity: 0.87

tctgtagaaattggaaatccaat	CRISPR spacer
actgtagaaaatggaaatccaac	Protospacer
 ********* ***********.

3. spacer 8.4|2773246|23|CP014064|CRT matches to AP014226 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S44-C3, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 3, identity: 0.87

tctgtagaaattggaaatccaat	CRISPR spacer
actgtagaaaatggaaatccaac	Protospacer
 ********* ***********.

4. spacer 8.4|2773246|23|CP014064|CRT matches to AP014225 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C9-MedDCM-OCT-S41-C89, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 3, identity: 0.87

tctgtagaaattggaaatccaat	CRISPR spacer
actgtagaaaatggaaatccaac	Protospacer
 ********* ***********.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

119 : 7864

Staphylococcus_phage(75.0%)

terminase,coat

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG40529.1\|119_461_+	pathogenicity island protein	Q4ZE66	Staphylococcus_phage	5.4e-57	97.3
AMG40530.1\|472_1051_+	pathogenicity island protein	A0A2H4JBG0	uncultured_Caudovirales_phage	1.3e-29	39.5
AMG40531.1\|1068_1287_+	hypothetical protein	NA	NA	NA	NA
AMG40532.1\|1337_1865_+\|coat	spore coat protein	Q4ZE87	Staphylococcus_phage	3.7e-89	97.1
AVC42096.1\|1996_2209_+	pathogenicity island family protein	Q4ZE86	Staphylococcus_phage	3.2e-31	97.1
AMG40534.1\|2205_2775_+\|terminase	terminase small subunit	Q4ZE85	Staphylococcus_phage	1.5e-99	96.3
AMG40535.1\|3972_4533_+	hypothetical protein	NA	NA	NA	NA
AMG40536.1\|4832_5387_-	hypothetical protein	A0A1W6JQE5	Staphylococcus_phage	5.2e-73	76.1
AMG40537.1\|6174_6975_+	exotoxin	A0A097PAT7	Streptococcus_pyogenes_phage	6.1e-51	43.8
AMG40538.1\|7141_7864_-	exotoxin	A0A1X9H080	Staphylococcus_phage	1.6e-26	34.9

DBSCAN-SWA_2

39675 : 87408

Staphylococcus_phage(72.46%)

head,plate,terminase,capsid,holin,integrase,tail,portal

attL 35924:35940|attR 64676:64692

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
35924:35940	attL	NA	NA	NA	NA
AMG40579.1\|39675_40917_+	cysteine desulfurase	Q2XUY6	environmental_halophage	8.2e-111	44.8
AMG40580.1\|40906_41371_+	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
AMG40581.1\|41521_42919_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
AMG40582.1\|42986_44036_-\|integrase	site-specific integrase	A1KWY3	Staphylococcus_virus	4.5e-203	99.7
AMG40583.1\|44148_44328_+	excisionase	Q4ZBP0	Staphylococcus_phage	3.7e-25	100.0
AMG40584.1\|44307_45240_-	hypothetical protein	A0EX19	Staphylococcus_virus	6.7e-174	100.0
AMG40585.1\|45271_45736_-	toxin	A0A0N9BAX8	Staphylococcus_phage	4.6e-83	98.1
AMG40586.1\|45748_46063_-	XRE family transcriptional regulator	A0A0N9BAW4	Staphylococcus_phage	9.8e-53	100.0
AMG40587.1\|46214_46451_+	transcriptional regulator	A0A0N9BAY2	Staphylococcus_phage	1.5e-37	100.0
AMG40588.1\|46464_46644_+	hypothetical protein	A0A0N9BAV3	Staphylococcus_phage	1.7e-25	100.0
AMG40589.1\|46744_47227_-	hypothetical protein	A0A0N9BAX2	Staphylococcus_phage	1.1e-82	100.0
AMG40590.1\|47286_48036_+	oxidoreductase	Q4ZBF7	Staphylococcus_virus	1.5e-136	100.0
AMG40591.1\|48051_48195_+	hypothetical protein	W5R8I6	Staphylococcus_phage	2.5e-16	100.0
AMG40592.1\|48204_48858_-	hypothetical protein	Q4ZBF5	Staphylococcus_virus	4.5e-116	100.0
AMG40593.1\|48928_49150_+	hypothetical protein	B2ZYU8	Staphylococcus_phage	8.7e-32	100.0
AMG40594.1\|49142_49304_+	DUF1270 domain-containing protein	D2JGJ6	Staphylococcus_phage	4.3e-20	100.0
AMG40595.1\|49395_49656_+	DUF1108 domain-containing protein	Q4ZDA1	Staphylococcus_virus	1.2e-43	100.0
AMG40596.1\|49665_49887_+	DUF2483 domain-containing protein	A0A1X9H047	Staphylococcus_phage	1.2e-33	100.0
AMG40597.1\|49879_50668_+	chromosomal replication initiator DnaA	Q4ZBM5	Staphylococcus_phage	2.6e-142	100.0
AMG40598.1\|50696_51248_+	single-stranded DNA-binding protein	Q4ZBM4	Staphylococcus_phage	3.4e-101	100.0
AMG40599.1\|51260_51932_+	hypothetical protein	A7TWM9	Staphylococcus_phage	2.0e-127	100.0
AMG40600.1\|52037_52895_-	DUF4393 domain-containing protein	Q4ZBL8	Staphylococcus_phage	9.5e-159	100.0
AMG40601.1\|52959_53730_+	replication protein	W5R8N2	Staphylococcus_phage	1.4e-116	100.0
AMG40602.1\|53739_54519_+	DNA replication protein DnaC	W5RAN3	Staphylococcus_phage	1.2e-144	100.0
AMG40604.1\|54686_54908_+	hypothetical protein	A7TWN4	Staphylococcus_phage	1.3e-35	100.0
AMG40605.1\|55326_55512_+	DUF3113 domain-containing protein	A0A068A236	Staphylococcus_phage	7.8e-26	95.1
AMG40606.1\|55512_55872_+	hypothetical protein	Q4ZBU0	Staphylococcus_virus	4.2e-60	96.6
AMG40607.1\|55871_56129_+	DUF3310 domain-containing protein	B5WZM8	Staphylococcus_phage	1.3e-42	98.8
AMG40608.1\|56131_56332_+	hypothetical protein	C5I650	Staphylococcus_phage	7.4e-30	98.5
AMG40609.2\|56340_56589_+	hypothetical protein	A0A2I6PF06	Staphylococcus_phage	5.2e-41	97.6
AMG40610.1\|56603_57005_+	hypothetical protein	A0A0H4IPW3	Staphylococcus_phage	7.1e-56	81.3
AMG40611.1\|57001_57196_+	hypothetical protein	A0A0U2A067	Staphylococcus_phage	6.3e-26	98.4
AMG40612.1\|57192_57630_+	hypothetical protein	NA	NA	NA	NA
AMG40613.1\|57626_57911_+	hypothetical protein	A1KX14	Staphylococcus_virus	4.4e-44	96.8
AMG40614.1\|57903_58152_+	DUF1024 domain-containing protein	A0A2K9VBU0	Staphylococcus_phage	5.4e-38	97.6
AMG40615.1\|58144_58681_+	dUTPase	R4IG63	Staphylococcus_phage	4.6e-95	99.4
AMG40616.1\|58717_58924_+	DUF1381 domain-containing protein	Q4ZCV6	Staphylococcus_virus	7.1e-20	98.5
AMG40617.1\|58920_59094_+	transcriptional regulator	Q4ZAX6	Staphylococcus_virus	1.1e-21	98.2
AMG40618.1\|59094_59241_+	hypothetical protein	A0A059T5A8	Staphylococcus_phage	2.2e-15	100.0
AMG40619.1\|59255_59675_+	transcriptional regulator	I1W651	Staphylococcus_phage	8.1e-71	100.0
AMG40620.1\|59860_60301_+\|terminase	terminase small subunit	I1W650	Staphylococcus_phage	2.4e-73	99.3
AMG40621.1\|60287_61565_+\|terminase	PBSX family phage terminase large subunit	Q8SDU9	Staphylococcus_phage	3.0e-249	100.0
AMG40622.1\|61575_63111_+\|portal	phage portal protein	Q8SDU8	Staphylococcus_phage	1.4e-290	99.2
AMG40623.1\|63117_64113_+\|head	phage head morphogenesis protein	S4V9L8	Staphylococcus_phage	3.8e-183	99.1
AMG40624.1\|64185_64356_+	hypothetical protein	Q4ZDF2	Staphylococcus_virus	9.7e-23	98.2
AMG40625.1\|64464_65085_+	DUF4355 domain-containing protein	B2ZYY4	Staphylococcus_phage	1.9e-71	95.6
64676:64692	attR	NA	NA	NA	NA
AMG40626.1\|65098_66073_+\|capsid	phage major capsid protein	E0Y3L0	Staphylococcus_virus	6.3e-183	99.4
AMG40627.1\|66094_66382_+	hypothetical protein	B7T0D3	Staphylococcus_virus	1.9e-42	91.6
AMG40628.1\|66390_66723_+\|head,tail	phage head-tail adapter protein	B7T0D4	Staphylococcus_virus	6.7e-52	95.5
AMG40629.1\|66719_67022_+	hypothetical protein	A4ZFB6	Staphylococcus_virus	3.3e-50	97.0
AMG40630.1\|67021_67369_+	hypothetical protein	A0A0F6N3F5	Staphylococcus_phage	4.1e-60	100.0
AMG40631.1\|67380_67764_+	hypothetical protein	Q8SDU1	Staphylococcus_phage	2.6e-68	100.0
AMG40632.1\|67782_68364_+\|tail	phage major tail protein, TP901-1 family	Q4ZDE5	Staphylococcus_virus	8.3e-106	100.0
AMG40633.1\|68425_68791_+\|tail	phage tail protein	A0A0F6N4J9	Staphylococcus_phage	3.6e-59	100.0
AMG40634.1\|68820_69165_+	hypothetical protein	A0A0F6N3F7	Staphylococcus_phage	2.5e-57	100.0
AMG40635.1\|69181_72646_+	hypothetical protein	S4V989	Staphylococcus_phage	5.6e-266	99.1
AMG40636.1\|72658_73606_+\|tail	phage tail family protein	Q8SDT6	Staphylococcus_phage	4.7e-183	99.7
AMG40637.1\|73614_75516_+	peptidase	Q8SDT5	Staphylococcus_phage	0.0e+00	100.0
AMG40638.1\|75530_77441_+	hypothetical protein	B2ZYZ7	Staphylococcus_phage	0.0e+00	99.1
AMG40639.1\|77440_79264_+\|plate	phage baseplate upper protein	Q9FZY8	Staphylococcus_virus	2.2e-282	96.4
AMG40640.1\|79263_79641_+	DUF2977 domain-containing protein	W5R9M2	Staphylococcus_phage	3.4e-60	99.2
AMG40641.2\|79650_79824_+	XkdX family protein	A0A059T7K6	Staphylococcus_phage	1.3e-27	100.0
AMG40642.1\|79864_80164_+	DUF2951 domain-containing protein	A0EWU6	Staphylococcus_virus	3.8e-46	98.0
AMG40643.1\|80300_82199_+	CHAP domain-containing protein	Q8SDT1	Staphylococcus_phage	0.0e+00	99.4
AMG40644.1\|82211_83384_+	DUF2479 domain-containing protein	Q8SDT0	Staphylococcus_phage	1.1e-197	99.7
AMG40645.1\|83389_83785_+	hypothetical protein	Q4ZBW9	Staphylococcus_virus	1.6e-68	100.0
AMG40646.1\|83840_84116_+\|holin	phage holin	A0A0F6N3M0	Staphylococcus_phage	8.6e-45	100.0
AMG40647.1\|84102_85515_+	CHAP domain-containing protein	A0A0F6N3N1	Staphylococcus_phage	6.4e-285	99.6
AMG40648.2\|85659_85812_+	hypothetical protein	A0A0F6N3H2	Staphylococcus_phage	3.1e-20	100.0
AMG40649.1\|85882_85993_+	hypothetical protein	W5R8J7	Staphylococcus_phage	1.7e-12	100.0
AMG40650.2\|85979_86180_+	hypothetical protein	W5R9N2	Staphylococcus_phage	3.7e-29	100.0
AMG40651.1\|86850_87408_+	hypothetical protein	W5R8Q1	Staphylococcus_phage	5.7e-104	100.0

DBSCAN-SWA_3

170283 : 223407

Streptococcus_phage(28.57%)

holin,bacteriocin,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG40731.1\|170283_171273_-\|tRNA	tryptophan--tRNA ligase	NA	NA	NA	NA
AMG40732.1\|171566_171962_+	transcriptional regulator Spx	NA	NA	NA	NA
AMG40733.1\|172332_173052_+	adaptor protein MecA	NA	NA	NA	NA
AMG40734.1\|173172_174159_+	competence protein CoiA	NA	NA	NA	NA
AMG40735.1\|174206_176015_+	oligoendopeptidase F	A0A1X9I5X5	Streptococcus_phage	5.5e-47	24.5
AMG40736.1\|176474_177281_-	DsbA family protein	NA	NA	NA	NA
AMG40737.1\|177303_177669_-	globin	NA	NA	NA	NA
AMG40738.1\|177772_178366_-	CYTH domain-containing protein	NA	NA	NA	NA
AMG40739.1\|178551_178899_+	hypothetical protein	NA	NA	NA	NA
AMG40740.1\|178915_179551_+	GTP pyrophosphokinase	NA	NA	NA	NA
AMG40741.1\|179567_180377_+	NAD(+) kinase	NA	NA	NA	NA
AMG40742.1\|180373_181228_+	RluA family pseudouridine synthase	NA	NA	NA	NA
AMG40743.1\|181248_182634_+	magnesium transporter	NA	NA	NA	NA
AMG40744.1\|182643_184488_+	sodium:proton antiporter	NA	NA	NA	NA
AMG40745.1\|184765_185536_+	enoyl-[acyl-carrier-protein] reductase FabI	NA	NA	NA	NA
AMG40746.1\|185732_186818_-	AI-2E family transporter	NA	NA	NA	NA
AMG40747.1\|187159_188728_+	alanine:cation symporter family protein	NA	NA	NA	NA
AMG40748.1\|188872_189631_+	esterase family protein	NA	NA	NA	NA
AMG40749.1\|189824_190334_+	hypothetical protein	NA	NA	NA	NA
AMG40750.2\|190446_191655_-	MFS transporter	NA	NA	NA	NA
AMG40751.1\|191614_192790_-	diacylglycerol beta-glucosyltransferase	NA	NA	NA	NA
AMG40752.1\|193222_194707_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	NA	NA	NA	NA
AMG40753.2\|194687_194948_+	hypothetical protein	NA	NA	NA	NA
AMG40754.1\|194947_196510_+	peptide chain release factor 3	A0A1S5SF82	Streptococcus_phage	1.7e-36	28.2
AMG40755.1\|196811_197615_+	hypothetical protein	S5MAL1	Bacillus_phage	1.6e-30	40.5
AMG40756.2\|197833_200158_+	PDZ domain-containing protein	W5SAB9	Pithovirus	2.8e-11	27.4
AMG40757.1\|200174_201533_+	Ktr system potassium uptake protein D	NA	NA	NA	NA
AMG40758.1\|201671_203183_+	bifunctional metallophosphatase/5'-nucleotidase	NA	NA	NA	NA
AMG40759.1\|203669_204239_-	competence protein ComK	NA	NA	NA	NA
AMG40760.1\|204448_204667_+	IDEAL domain-containing protein	NA	NA	NA	NA
AMG40761.1\|204747_205734_-	lipoate--protein ligase	NA	NA	NA	NA
AMG40762.1\|205932_206109_+	DUF2187 domain-containing protein	NA	NA	NA	NA
AMG40763.1\|206123_206726_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
AMG40764.2\|207025_207103_+\|holin	putative holin-like toxin	NA	NA	NA	NA
AMG40765.1\|207641_207743_+	hypothetical protein	NA	NA	NA	NA
AVC42097.1\|207752_208025_+\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA
AMG40766.1\|208068_210033_+	DUF1430 domain-containing protein	NA	NA	NA	NA
AMG40767.1\|210035_210356_+	hypothetical protein	NA	NA	NA	NA
AMG40768.1\|210352_210994_+\|bacteriocin	bacteriocin ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.7e-19	33.0
AVC42028.1\|211081_211372_-	hypothetical protein	NA	NA	NA	NA
AVC42029.1\|211512_211650_+	poly(glycerol-phosphate) alpha-glucosyltransferase	NA	NA	NA	NA
AMG40769.1\|211738_212095_-	DoxX family protein	NA	NA	NA	NA
AMG40770.1\|212582_213542_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
AMG40771.2\|213587_213719_-	hypothetical protein	NA	NA	NA	NA
AMG40772.2\|213782_214073_-	NINE protein	A0A060AN66	Enterococcus_phage	7.5e-07	38.0
AMG40773.1\|214162_214714_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
AMG40774.1\|214765_215704_-	1,4-dihydroxy-2-naphthoate polyprenyltransferase	NA	NA	NA	NA
AVC42030.1\|215854_215959_+	hypothetical protein	NA	NA	NA	NA
AMG40775.2\|216035_217247_+	isochorismate synthase	NA	NA	NA	NA
AMG40776.1\|217233_218907_+	2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase	NA	NA	NA	NA
AMG40777.1\|218893_219697_+	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase	NA	NA	NA	NA
AMG40778.1\|219689_220511_+	1,4-dihydroxy-2-naphthoyl-CoA synthase	NA	NA	NA	NA
AMG40779.1\|220748_221078_-	staphostatin B	NA	NA	NA	NA
AMG40780.1\|221115_222297_-\|protease	cysteine protease staphopain B	NA	NA	NA	NA
AMG40781.1\|222378_223407_-\|protease	serine protease	A0A2H4PQP7	Staphylococcus_phage	6.3e-16	32.3

DBSCAN-SWA_4

241828 : 250301

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG40797.1\|241828_242311_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	4.0e-21	44.0
AMG40798.1\|242297_243422_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
AMG40799.1\|243425_244130_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	42.1
AMG40800.1\|244129_244393_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
AMG40801.1\|244394_245066_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
AMG40802.1\|245058_247248_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	3.5e-141	39.8
AMG40803.1\|247226_248711_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.9e-45	31.7
AMG40804.1\|248703_249732_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	3.4e-62	41.7
AMG40805.1\|249734_250301_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	6.1e-29	40.1

DBSCAN-SWA_5

870256 : 879299

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG41379.1\|870256_870775_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
AMG41380.1\|870796_873070_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	8.1e-64	29.3
AMG41381.1\|873272_875552_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
AMG41382.1\|875826_876087_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
AMG41383.1\|876105_877245_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
AMG41384.1\|877267_878293_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
AVC42040.1\|878294_879299_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_6

993327 : 1066360

Staphylococcus_phage(95.74%)

transposase,tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG41491.1\|993327_993972_-\|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
AMG41492.1\|993986_994778_-	phosphotransferase	NA	NA	NA	NA
AMG41493.1\|995227_996076_-	D-amino-acid transaminase	NA	NA	NA	NA
AMG41494.1\|996079_997489_-	dipeptidase PepV	NA	NA	NA	NA
AMG41495.1\|998046_998469_-	YtxH domain-containing protein	NA	NA	NA	NA
AMG41496.1\|998485_999181_-	rRNA pseudouridine synthase	NA	NA	NA	NA
AMG41497.1\|999177_1000839_-	polysaccharide biosynthesis protein	NA	NA	NA	NA
AMG41498.1\|1001245_1002514_+	NAD(P)/FAD-dependent oxidoreductase	A0A2H4PQX1	Staphylococcus_phage	9.1e-57	99.1
AMG41499.1\|1002630_1009191_-	DUF1542 domain-containing protein	A0A2H4PQU6	Staphylococcus_phage	6.1e-306	98.3
AMG41500.1\|1009516_1009828_-	rhodanese-like domain-containing protein	A0A2H4PQR9	Staphylococcus_phage	4.8e-52	99.0
AMG41501.2\|1009849_1012267_-\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.5
AMG41502.1\|1012554_1013736_-	MFS transporter	A0A2H4PQR6	Staphylococcus_phage	7.3e-218	99.7
AMG41503.1\|1013845_1014799_+	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
AMG41504.1\|1014795_1015359_+	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
AMG41505.1\|1015481_1015883_-	MarR family transcriptional regulator	NA	NA	NA	NA
AMG41506.1\|1016454_1017282_-	alpha/beta hydrolase	NA	NA	NA	NA
AMG41507.2\|1017284_1017404_-	hypothetical protein	NA	NA	NA	NA
AMG41508.1\|1017515_1018517_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	2.6e-184	99.4
AMG41509.1\|1018638_1019103_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	4.5e-70	100.0
AMG41510.1\|1019115_1020297_-	riboflavin biosynthesis protein RibBA	A0A2H4PQS2	Staphylococcus_phage	5.6e-226	99.5
AMG41511.1\|1020307_1020940_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	5.5e-111	98.6
AMG41512.2\|1020946_1021978_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	4.0e-196	98.8
AMG41513.1\|1022470_1023973_-	pyridine nucleotide-disulfide oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	1.9e-29	98.6
AMG41514.1\|1024495_1024810_+	ArsR family transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	9.8e-53	98.1
AMG41515.1\|1024809_1026102_+	arsenical efflux pump membrane protein ArsB	A0A2H4PQU3	Staphylococcus_phage	5.0e-228	99.5
AMG41516.1\|1026188_1027043_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
AMG41517.1\|1027318_1027543_-	hypothetical protein	NA	NA	NA	NA
AMG41518.1\|1027741_1028212_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	8.8e-82	98.1
AMG41519.1\|1028324_1028768_+	competence protein ComK	NA	NA	NA	NA
AMG41520.1\|1028754_1029198_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-57	98.6
AMG41521.1\|1029493_1030129_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
AMG41522.1\|1030568_1031282_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
AMG41523.1\|1031541_1031844_+	hypothetical protein	NA	NA	NA	NA
AMG41524.1\|1032156_1033476_+\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
AMG41525.1\|1033619_1033985_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
AMG41526.1\|1033981_1034335_+	camphor resistance protein CrcB	A0A2H4PQQ7	Staphylococcus_phage	3.8e-21	94.0
AMG41529.1\|1036331_1037165_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	7.8e-158	99.3
AMG41530.1\|1037376_1038285_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.4e-138	100.0
AMG41531.1\|1038406_1039603_-	S-adenosylmethionine synthase	A0A2H4PQS6	Staphylococcus_phage	4.3e-218	99.5
AMG41532.1\|1039974_1041567_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	100.0
AMG41533.2\|1041944_1042691_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	1.4e-142	98.8
AMG41534.2\|1042695_1043169_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	7.2e-84	98.7
AMG41535.1\|1043234_1043492_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
AMG41536.1\|1043488_1044490_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	5.3e-185	97.3
AMG41537.1\|1044494_1045973_-	2-succinylbenzoate-CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.8e-283	97.6
AMG41538.2\|1046131_1046587_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	3.6e-80	99.3
AMG41539.2\|1046889_1047540_+	calcium-binding protein	A0A2H4PQM8	Staphylococcus_phage	2.9e-51	94.0
AMG41540.1\|1047620_1048616_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	2.6e-67	97.9
AMG41541.1\|1048690_1049317_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	3.1e-74	79.8
AMG41542.1\|1049357_1049699_+	DUF3969 domain-containing protein	A0A2H4PQN6	Staphylococcus_phage	1.1e-54	94.7
AMG41543.1\|1049799_1050372_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	2.3e-23	93.1
AMG41547.1\|1051944_1052046_+	hypothetical protein	NA	NA	NA	NA
AMG41549.1\|1053121_1054351_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	4.0e-134	64.7
AMG41550.2\|1054343_1056083_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	2.4e-289	100.0
AMG41551.1\|1056063_1056198_-	hypothetical protein	NA	NA	NA	NA
AMG41552.1\|1056260_1056980_-\|protease	serine protease SplF	A0A2H4PQP1	Staphylococcus_phage	1.9e-131	99.6
AVC42042.1\|1057081_1057189_+	hypothetical protein	NA	NA	NA	NA
AMG41553.1\|1057137_1057857_-\|protease	serine protease SplD	A0A2H4PQP9	Staphylococcus_phage	4.6e-130	99.6
AMG41554.1\|1057977_1058697_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	1.3e-129	98.7
AMG41555.1\|1058754_1059477_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	3.5e-130	98.3
AMG41556.1\|1059601_1060309_-\|protease	serine protease SplA	A0A2H4PQN3	Staphylococcus_phage	7.9e-127	97.0
AMG41557.1\|1060744_1060963_-	hypothetical protein	NA	NA	NA	NA
AMG41558.1\|1061272_1061854_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	1.6e-53	64.2
AMG41559.1\|1062326_1062545_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	2.0e-25	80.6
AMG41560.1\|1062800_1063274_+	hypothetical protein	NA	NA	NA	NA
AMG41561.1\|1063278_1064070_+	DUF1828 domain-containing protein	NA	NA	NA	NA
AMG41562.1\|1064439_1065423_-	bi-component leukocidin LukED subunit D	A0A2H4PQH7	Staphylococcus_phage	1.8e-185	99.4
AMG41563.1\|1065424_1066360_-	beta-channel forming cytolysin	A0A2H4PQI5	Staphylococcus_phage	1.4e-174	100.0

DBSCAN-SWA_7

1072561 : 1076808

Staphylococcus_phage(66.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG41569.1\|1072561_1073317_-	exotoxin	A0A075M4C7	Staphylococcus_phage	6.0e-40	41.4
AMG41570.1\|1073355_1073751_-	enterotoxin	A0A097PAT7	Streptococcus_pyogenes_phage	1.5e-26	50.4
AMG41571.1\|1073725_1074127_-	enterotoxin	A0A097PAT7	Streptococcus_pyogenes_phage	1.5e-10	37.9
AMG41572.1\|1074280_1075009_-	exotoxin	A0A1X9H080	Staphylococcus_phage	1.1e-27	39.2
AMG41573.1\|1075043_1075763_-	exotoxin	A0A1X9H080	Staphylococcus_phage	2.3e-25	35.8
AMG41574.1\|1076043_1076808_-	exotoxin	A0A1X9H080	Staphylococcus_phage	2.3e-31	37.1

DBSCAN-SWA_8

1171098 : 1253193

108

Staphylococcus_phage(88.16%)

head,protease,terminase,holin,capsid,integrase,tail,portal

attL 1220157:1220174|attR 1244333:1244350

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG41658.1\|1171098_1172265_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
AMG41659.1\|1172295_1172622_+	staphostatin A	NA	NA	NA	NA
AMG41660.1\|1172913_1173087_-	NETI motif-containing protein	NA	NA	NA	NA
AMG41661.1\|1173067_1173670_-	DUF2179 domain-containing protein	NA	NA	NA	NA
AMG41662.1\|1173940_1174762_-	NAD(+) synthetase	G3MA24	Bacillus_virus	2.3e-69	52.7
AMG41663.1\|1174754_1176224_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	5.9e-108	45.1
AMG41664.1\|1176407_1177484_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
AMG41665.1\|1177503_1178298_+	ACT domain-containing protein	NA	NA	NA	NA
AMG41666.1\|1178369_1178477_+	hypothetical protein	NA	NA	NA	NA
AMG41667.1\|1178487_1180050_-	sodium-dependent dicarboxylate transporter SdcS	NA	NA	NA	NA
AMG41668.1\|1180254_1181352_-	pectate lyase	U5PWM6	Bacillus_phage	3.3e-47	34.6
AMG41669.1\|1181720_1182281_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
AMG41670.1\|1182333_1183263_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
AMG43219.2\|1183455_1183629_-	hypothetical protein	NA	NA	NA	NA
AMG41671.1\|1183680_1185060_+	aldehyde dehydrogenase	NA	NA	NA	NA
AMG41672.1\|1185179_1186208_-	hypothetical protein	NA	NA	NA	NA
AMG41673.1\|1186477_1186879_+	YolD-like family protein	U3PG23	Staphylococcus_phage	6.0e-23	42.9
AMG41674.1\|1187451_1187625_-	hypothetical protein	NA	NA	NA	NA
AMG41675.1\|1188075_1189116_+	linear amide C-N hydrolase	NA	NA	NA	NA
AMG41676.1\|1189172_1190015_-	hypothetical protein	NA	NA	NA	NA
AMG41677.1\|1190011_1190569_-	DUF1700 domain-containing protein	NA	NA	NA	NA
AMG41678.1\|1190628_1191153_-	hypothetical protein	NA	NA	NA	NA
AMG41679.1\|1191273_1191837_+	thioredoxin family protein	NA	NA	NA	NA
AMG41680.1\|1191902_1192643_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
AMG41681.1\|1192642_1193515_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	1.0e-27	36.0
AMG41682.1\|1193511_1194192_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
AMG41683.1\|1194192_1195089_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	5.0e-17	30.2
AMG41684.1\|1195085_1195466_-	GntR family transcriptional regulator	NA	NA	NA	NA
AMG41685.1\|1195723_1195900_-	hypothetical protein	NA	NA	NA	NA
AMG41686.1\|1196142_1196241_-	hypothetical protein	NA	NA	NA	NA
AMG41687.1\|1196440_1197727_+	aspartate aminotransferase	NA	NA	NA	NA
AMG41688.1\|1198005_1198296_-	MAP domain-containing protein	NA	NA	NA	NA
AMG41689.1\|1198306_1199740_-	MAP domain-containing protein	NA	NA	NA	NA
AMG41690.1\|1200125_1200326_+	hypothetical protein	A0A1P8L6A7	Staphylococcus_phage	3.4e-27	100.0
AMG41691.1\|1200697_1200877_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	1.4e-24	98.3
AVC42044.1\|1200900_1201209_+	hypothetical protein	M9NTD8	Staphylococcus_phage	3.2e-40	100.0
AMG41693.2\|1201187_1201448_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
AMG41694.1\|1201500_1201851_-	inhibitor	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
AMG41695.1\|1202360_1202657_-	peptidoglycan hydrolase	A0A1P8L6B4	Staphylococcus_phage	1.6e-49	95.9
AVC42045.1\|1202563_1202818_-	amidase	Q4ZCK0	Staphylococcus_virus	8.0e-13	93.0
AVC42046.1\|1202744_1202900_+	amidase	NA	NA	NA	NA
AMG41696.1\|1203346_1203838_-	staphylokinase	A0A1W6JQ12	Staphylococcus_phage	4.7e-86	99.4
AMG41697.1\|1204028_1204784_-	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
AMG41698.1\|1204795_1205050_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
AMG41699.1\|1205101_1205209_+	hypothetical protein	NA	NA	NA	NA
AVC42100.1\|1205261_1205438_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	2.2e-22	98.3
AMG43220.2\|1205640_1206423_-	exotoxin	A0A075M4C7	Staphylococcus_phage	1.6e-149	99.6
AMG41700.1\|1206834_1207209_-	hypothetical protein	G4KNR3	Staphylococcus_phage	3.3e-39	100.0
AMG41701.1\|1207264_1207552_-	hypothetical protein	A0A075LZJ6	Staphylococcus_phage	5.8e-44	100.0
AMG41702.1\|1207598_1207751_-	hypothetical protein	D2JLG0	Staphylococcus_phage	1.2e-19	98.0
AMG41703.1\|1207740_1211526_-	hypothetical protein	A0A1X9H0H3	Staphylococcus_phage	0.0e+00	98.3
AMG41704.1\|1211541_1213026_-\|tail	phage tail protein	A0A2I6PDJ0	Staphylococcus_phage	1.2e-297	100.0
AMG41705.1\|1217795_1218146_-	hypothetical protein	G4KNQ8	Staphylococcus_phage	7.8e-59	100.0
AVC42047.1\|1218195_1218420_-	hypothetical protein	A0A075LYE8	Staphylococcus_phage	3.0e-32	100.0
AMG41706.1\|1218461_1219106_-\|tail	phage tail protein	A0EWZ9	Staphylococcus_phage	1.2e-118	99.1
AMG41707.1\|1219106_1219514_-	hypothetical protein	G4KNQ6	Staphylococcus_phage	7.1e-72	100.0
AMG41708.1\|1219510_1219915_-	hypothetical protein	G4KNQ5	Staphylococcus_phage	4.3e-69	100.0
AMG41709.1\|1219911_1220274_-\|head,tail	phage head-tail adapter protein	G4KNQ4	Staphylococcus_phage	4.4e-65	100.0
1220157:1220174	attL	NA	NA	NA	NA
AMG41710.1\|1220257_1220542_-\|head,tail	phage head-tail adapter protein	A0A2I6PDJ5	Staphylococcus_phage	4.0e-45	98.9
AMG41711.1\|1220531_1220816_-	hypothetical protein	A0A2I6PDJ3	Staphylococcus_phage	1.8e-45	100.0
AMG41712.1\|1220835_1221981_-\|capsid	phage major capsid protein	G4KNQ3	Staphylococcus_phage	9.6e-215	100.0
AMG41713.1\|1222004_1222742_-\|protease	Clp protease ClpP	G4KNQ2	Staphylococcus_phage	4.0e-129	99.6
AMG41714.1\|1222725_1223913_-\|portal	phage portal protein	A0A2I6PDI1	Staphylococcus_phage	1.0e-219	100.0
AMG41715.1\|1223928_1225590_-\|terminase	terminase large subunit	A0A2I6PDJ8	Staphylococcus_phage	0.0e+00	100.0
AMG43221.1\|1225586_1225931_-	hypothetical protein	G4KNP9	Staphylococcus_phage	9.4e-57	100.0
AMG41716.1\|1226060_1226360_-	HNH endonuclease	A0EWY8	Staphylococcus_phage	4.6e-52	100.0
AMG41717.1\|1226591_1227008_-	transcriptional regulator	G4KNP7	Staphylococcus_phage	1.3e-76	100.0
AMG41718.1\|1227035_1227236_-	hypothetical protein	A0A2I6PDV9	Staphylococcus_phage	1.4e-28	100.0
AMG41719.1\|1227235_1227385_-	transcriptional regulator	A0A1W6JPZ2	Staphylococcus_phage	8.2e-18	98.0
AMG41720.1\|1227381_1227768_-	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
AMG41721.1\|1227764_1227971_-	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
AMG41722.1\|1227967_1228213_-	hypothetical protein	A0A2I6PDW7	Staphylococcus_phage	5.0e-36	100.0
AMG41723.1\|1228249_1228786_-	dUTPase	A0A1W6JQ21	Staphylococcus_phage	9.4e-96	100.0
AMG41724.1\|1228935_1229190_-	DUF1024 domain-containing protein	A0A0H3U469	Staphylococcus_phage	5.0e-39	100.0
AMG41725.1\|1229204_1229447_-	hypothetical protein	Q4ZDP7	Staphylococcus_virus	2.1e-39	95.0
AMG41726.1\|1229450_1229819_-	hypothetical protein	A0A0H3U2T3	Staphylococcus_phage	2.0e-49	100.0
AVC42101.1\|1229831_1230140_-	RusA family crossover junction endodeoxyribonuclease	A0EWX6	Staphylococcus_phage	1.6e-52	100.0
AMG41727.1\|1230242_1230461_-	hypothetical protein	A0A2I6PDG4	Staphylococcus_phage	1.0e-37	100.0
AMG41728.1\|1230516_1231362_-	DnaD domain protein	A0A2I6PDG7	Staphylococcus_phage	7.0e-130	99.3
AMG41729.1\|1231391_1231862_-	Single-stranded DNA-binding protein 1	A0EWX3	Staphylococcus_phage	7.4e-81	99.4
AMG41730.2\|1231862_1232480_-	MBL fold metallo-hydrolase	A0A0H3U2T4	Staphylococcus_phage	4.1e-87	100.0
AMG41731.1\|1232560_1233481_-	recombinase	A0A2I6PDH5	Staphylococcus_phage	2.3e-166	100.0
AMG41732.1\|1233482_1235426_-	ATPase	S4V9K6	Staphylococcus_phage	0.0e+00	100.0
AVC42048.1\|1235434_1235698_-	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	7.7e-43	100.0
AMG41733.1\|1235706_1235967_-	DUF1108 domain-containing protein	A0A1P8L6F5	Staphylococcus_phage	5.2e-44	100.0
AMG41734.1\|1235971_1236274_-	hypothetical protein	A0A1P8L6F8	Staphylococcus_phage	7.0e-48	100.0
AMG41735.1\|1236366_1236528_-	DUF1270 domain-containing protein	D2JGJ6	Staphylococcus_phage	7.2e-20	98.1
AMG41736.1\|1236524_1236845_-	DUF771 domain-containing protein	Q4ZDR7	Staphylococcus_virus	1.5e-56	100.0
AMG41737.1\|1236874_1237093_-	hypothetical protein	Q4ZBN1	Staphylococcus_phage	2.1e-30	97.2
AMG41738.1\|1237123_1237318_-	hypothetical protein	A0A1X9H0A2	Staphylococcus_phage	1.5e-19	100.0
AMG41739.1\|1237334_1238087_-	oxidoreductase	A0A1X9H0A0	Staphylococcus_phage	1.5e-139	99.2
AMG41740.1\|1238137_1238467_+	hypothetical protein	M9NS98	Staphylococcus_phage	2.7e-53	100.0
AMG41741.1\|1238455_1238671_-	DUF2829 domain-containing protein	A0A0H3U4C7	Staphylococcus_phage	4.8e-35	100.0
AMG41742.1\|1238686_1238950_-	XRE family transcriptional regulator	A0A2I6PF09	Staphylococcus_phage	7.2e-41	100.0
AMG41743.1\|1238946_1239120_-	transcriptional regulator	NA	NA	NA	NA
AMG41744.1\|1239082_1239796_+	XRE family transcriptional regulator	M9NUL0	Staphylococcus_phage	1.2e-130	100.0
AMG41745.1\|1239811_1240744_+	ATP-dependent helicase	A0A2I6PEZ7	Staphylococcus_phage	5.7e-173	100.0
AMG41746.1\|1240749_1241091_+	hypothetical protein	A0A2I6PF04	Staphylococcus_phage	4.6e-56	100.0
AMG41747.1\|1241294_1241477_+	hypothetical protein	M9NSW6	Staphylococcus_phage	4.1e-27	100.0
AMG41748.1\|1241576_1242041_+	hypothetical protein	A0EWV3	Staphylococcus_phage	1.1e-28	100.0
AMG41749.1\|1242099_1243137_+\|integrase	site-specific integrase	A0EWV2	Staphylococcus_phage	9.1e-180	100.0
AMG41751.1\|1244255_1245272_-	bi-component leukocidin LukGH subunit G	A0A1X9IGW5	Staphylococcus_phage	6.7e-26	30.2
1244333:1244350	attR	NA	NA	NA	NA
AMG41752.1\|1245293_1246349_-	bi-component leukocidin LukGH subunit H	A0A1X9IGW5	Staphylococcus_phage	2.8e-35	34.3
AMG41753.1\|1246784_1248008_+	succinyl-diaminopimelate desuccinylase	NA	NA	NA	NA
AMG41754.1\|1248451_1249759_+	TrkH family potassium uptake protein	NA	NA	NA	NA
AMG41755.1\|1250298_1251915_-	molecular chaperone GroEL	A0A240F779	uncultured_virus	3.4e-157	54.7
AMG41756.1\|1251990_1252275_-	co-chaperone GroES	A0A221S386	uncultured_virus	4.7e-14	46.2
AMG41757.1\|1252449_1253193_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_9

2404447 : 2410188

Staphylococcus_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG42838.1\|2404447_2405368_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.0e-41	42.2
AMG42839.1\|2405360_2406098_+	ABC transporter permease	NA	NA	NA	NA
AMG42840.1\|2406111_2406315_+	UDP kinase	NA	NA	NA	NA
AMG42841.1\|2406344_2407019_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.7e-126	97.3
AVC42083.1\|2407180_2407747_+	adenylyltransferase	E4ZFP8	Streptococcus_phage	3.9e-108	99.5
AMG42842.1\|2407791_2408322_+	streptothricin N-acetyltransferase Sat4	A0A1B0RXL7	Streptococcus_phage	1.3e-89	97.8
AMG42843.1\|2408414_2409209_+	aminoglycoside O-phosphotransferase APH(3')-IIIa	E4ZFP6	Streptococcus_phage	2.3e-154	100.0
AMG42844.1\|2409513_2410188_-\|transposase	IS6-like element IS257 family transposase	A0A0N9RU54	Staphylococcus_phage	6.8e-128	99.6

DBSCAN-SWA_10

2704703 : 2712524

Hokovirus(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG43106.1\|2704703_2705759_-	two-component sensor histidine kinase	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
AMG43107.1\|2705758_2706445_-	DNA-binding response regulator	NA	NA	NA	NA
AMG43108.1\|2706419_2706893_-	DoxX family protein	NA	NA	NA	NA
AMG43109.1\|2707235_2707676_-	hypothetical protein	NA	NA	NA	NA
AMG43110.1\|2707955_2708540_-	hypothetical protein	NA	NA	NA	NA
AMG43111.1\|2708638_2709352_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
AMG43112.1\|2709355_2709775_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
AMG43113.1\|2709776_2710445_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
AMG43114.1\|2710795_2711389_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.4e-38	42.9
AMG43115.1\|2711372_2712524_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	6.0e-23	35.7

DBSCAN-SWA_11

2728556 : 2739192

uncultured_Caudovirales_phage(62.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG43130.1\|2728556_2730062_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
AVC42093.1\|2730127_2730373_-	hypothetical protein	NA	NA	NA	NA
AMG43131.1\|2730402_2730903_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.9e-52	71.5
AMG43132.1\|2730922_2731789_-	EamA/RhaT family transporter	NA	NA	NA	NA
AVC42094.1\|2732173_2732440_+	ribonucleoside-diphosphate reductase	NA	NA	NA	NA
AMG43133.1\|2732589_2732988_+	protein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
AMG43134.1\|2732950_2735056_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
AMG43135.1\|2735173_2736145_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
AMG43136.1\|2736325_2736481_+	hypothetical protein	NA	NA	NA	NA
AMG43245.1\|2736519_2737491_+	iron ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	4.3e-139	78.9
AMG43137.1\|2737477_2738434_+	iron ABC transporter permease	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
AMG43138.1\|2738430_2739192_+	iron ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	6.5e-18	31.6

DBSCAN-SWA_12

2790149 : 2800969

Staphylococcus_phage(80.0%)

integrase

attL 2781218:2781233|attR 2800295:2800310

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2781218:2781233	attL	NA	NA	NA	NA
AMG43185.1\|2790149_2792507_+	ribonuclease R	Q0GXV6	Lactococcus_phage	2.8e-91	38.5
AMG43186.1\|2792528_2792993_+	SsrA-binding protein	W5RAM5	Staphylococcus_phage	3.6e-80	98.1
AMG43187.1\|2793555_2794662_-\|integrase	site-specific integrase	H0UST3	Bacillus_phage	3.1e-77	44.2
AMG43188.2\|2794667_2795315_-	XRE family transcriptional regulator	NA	NA	NA	NA
AMG43189.1\|2795472_2795679_+	hypothetical protein	NA	NA	NA	NA
AMG43190.1\|2795714_2795942_+	XRE family transcriptional regulator	NA	NA	NA	NA
AVC42095.1\|2795938_2796112_+	pathogenicity island protein	NA	NA	NA	NA
AMG43191.1\|2796078_2796282_+	pathogenicity island protein	A0A1W6JQF4	Staphylococcus_phage	2.0e-30	98.5
AMG43192.1\|2796283_2796667_+	pathogenicity island protein	A0A1W6JQI7	Staphylococcus_phage	2.6e-63	96.9
AMG43193.1\|2796667_2796985_+	DUF1474 domain-containing protein	A0A1W6JQH0	Staphylococcus_phage	1.2e-18	52.3
AMG43194.1\|2797048_2797918_+	mobile element-associated protein	Q4ZE74	Staphylococcus_phage	8.2e-158	92.0
AMG43195.1\|2797931_2799641_+	DUF927 domain-containing protein	Q4ZE73	Staphylococcus_phage	3.2e-299	92.4
AMG43196.1\|2799950_2800331_+	hypothetical protein	Q4ZE71	Staphylococcus_phage	1.7e-67	97.6
2800295:2800310	attR	NA	NA	NA	NA
AMG43197.1\|2800327_2800969_+	pathogenicity island protein	Q4ZE67	Staphylococcus_phage	7.2e-111	93.0

Anti-CRISPR protein detection

Acr_ID: CP014064.2|AMG41685.1|1195723_1195900_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr_ID: CP014064.2|AMG41686.1|1196142_1196241_-|hypothetical-protein

Click the colored protein region to show detailed information

Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

CP014064.2|AMG41685.1|1195723_1195900_-|hypothetical-protein

1195723_1195900_-

58 aa aa

WHTH_GntR

Identity	Hit_domain_coverage
0.48484848484848486	1.0

1171098-1253193

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
CP014064_8	Unclear	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	1248310-1248332	2
CP014064_8	Unclear	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	1248310-1248332	2

1. spacer 8.2|2773129|23|CP014064|CRT matches to CP014064 position: 1248310-1248332, mismatch: 2

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

2. spacer 8.4|2773246|23|CP014064|CRT matches to CP014064 position: 1248310-1248332, mismatch: 2

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

CP014064.2|AMG41686.1|1196142_1196241_-|hypothetical-protein

1196142_1196241_-

32 aa aa

WHTH_GntR

Identity	Hit_domain_coverage
0.48484848484848486	1.0

1171098-1253193

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
CP014064_8	Unclear	8.2\|2773129\|23\|CP014064\|CRT	2773129-2773151	23	1248310-1248332	2
CP014064_8	Unclear	8.4\|2773246\|23\|CP014064\|CRT	2773246-2773268	23	1248310-1248332	2

1. spacer 8.2|2773129|23|CP014064|CRT matches to CP014064 position: 1248310-1248332, mismatch: 2

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

2. spacer 8.4|2773246|23|CP014064|CRT matches to CP014064 position: 1248310-1248332, mismatch: 2

tctgtagaaattggaaatccaat	CRISPR spacer
tctgttgaaattgggaatccaat	Protospacer
***** ********.********

2. CP014063

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

0 : 15431

Salmonella_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG40527.1\|1250_2021_+	DUF536 domain-containing protein	NA	NA	NA	NA
AMG40488.1\|2219_2738_-	type 1 glutamine amidotransferase	NA	NA	NA	NA
AMG40489.1\|2826_3462_-	3-hexulose-6-phosphate synthase	NA	NA	NA	NA
AMG40490.1\|3564_3915_+	transcriptional regulator	NA	NA	NA	NA
AMG40491.1\|4510_5482_-	NADPH:quinone reductase	NA	NA	NA	NA
AMG40492.1\|5605_6025_+	MarR family transcriptional regulator	NA	NA	NA	NA
AMG40493.1\|6525_7371_-	penicillin-hydrolyzing class A beta-lactamase BlaZ	A0A1B0VBP7	Salmonella_phage	9.8e-31	34.1
AMG40494.1\|7477_9235_+	beta-lactam sensor/signal transducer BlaR1	NA	NA	NA	NA
AMG40495.1\|9224_9605_+	penicillinase repressor BlaI	NA	NA	NA	NA
AMG40496.1\|9868_10447_+	HTH domain-containing protein	A0A0A7NPV4	Enterobacteria_phage	2.4e-41	51.7
AMG40497.1\|10573_11185_+	transposon DNA-invertase	I1ZBD6	Salisaeta_icosahedral_phage	6.4e-16	29.5
AMG40498.1\|11455_13678_-	helicase	NA	NA	NA	NA
AMG40499.2\|13670_15431_-	site-specific DNA-methyltransferase	A0A2K5B255	Erysipelothrix_phage	2.4e-31	29.2

DBSCAN-SWA_2

19910 : 22724

Streptococcus_phage(50.0%)

bacteriocin,integrase,transposase

attL 11349:11370|attR 30188:30209

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
11349:11370	attL	NA	NA	NA	NA
AMG40504.1\|19910_20258_+	transcriptional regulator	E4ZFI8	Streptococcus_phage	4.9e-13	36.8
AMG40505.1\|20448_20568_+	replication protein	NA	NA	NA	NA
AMG40506.1\|20607_21237_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.5e-105	88.5
AVC42024.1\|21343_21754_+\|integrase	site-specific integrase	A3F636	Streptococcus_phage	2.9e-28	51.4
AMG40528.1\|21943_22246_+\|bacteriocin	bacteriocin transporter	NA	NA	NA	NA
AMG40507.1\|22523_22724_+	transcriptional regulator	A0A142LP09	Marinitoga_camini_virus	6.7e-07	43.5
30188:30209	attR	NA	NA	NA	NA

DBSCAN-SWA_3

26278 : 34940

Staphylococcus_phage(80.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AMG40513.1\|26278_28438_+	peptidase domain-containing ABC transporter	W8CYL7	Bacillus_phage	9.8e-43	25.7
AMG40514.1\|28439_29435_+	HlyD family secretion protein	NA	NA	NA	NA
AMG40515.1\|29476_30151_-\|transposase	IS6 family transposase ISSau6	A0A0N9RU54	Staphylococcus_phage	1.3e-113	88.4
AMG40516.2\|30410_30794_-	hypothetical protein	NA	NA	NA	NA
AMG40517.1\|30909_31653_+	epidermal cell differentiation inhibitor	NA	NA	NA	NA
AMG40518.1\|31994_32669_-\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.5e-114	87.5
AMG40519.1\|32776_33529_-	exotoxin	A0A075M4C7	Staphylococcus_phage	1.3e-74	58.3
AMG40520.1\|34265_34940_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.5e-114	87.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP014064

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

2. CP014063

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection