CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
CP016686	Lactococcus lactis subsp. cremoris strain 158 plasmid p158B, complete sequence	0 crisprs	WYL	0
CP016688	Lactococcus lactis subsp. cremoris strain 158 plasmid p158D, complete sequence	0 crisprs	NA	0
CP016689	Lactococcus lactis subsp. cremoris strain 158 plasmid p158E, complete sequence	0 crisprs	NA	0
CP016685	Lactococcus lactis subsp. cremoris strain 158 plasmid p158A, complete sequence	0 crisprs	NA	1
CP015894	Lactococcus lactis subsp. cremoris strain 158 chromosome, complete genome	1 crisprs	cas3,DEDDh,WYL,csa3,DinG	12
CP016690	Lactococcus lactis subsp. cremoris strain 158 plasmid p158F, complete sequence	0 crisprs	NA	0
CP016687	Lactococcus lactis subsp. cremoris strain 158 plasmid p158C, complete sequence	0 crisprs	NA	0
CP034596	Lactococcus lactis subsp. cremoris strain 158 plasmid p158g, complete sequence	0 crisprs	NA	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3148 : 43967

Lactococcus_phage(37.04%)

bacteriocin,integrase,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD90086.1\|3148_3907_+	chromosome partitioning protein ParA	H7BUL8	unidentified_phage	1.6e-16	28.4
ARD90087.1\|3910_4639_+	chromosome segregation DNA-binding protein	Q4ZC37	Staphylococcus_virus	7.2e-06	27.7
ARD90088.1\|4668_5019_-	hypothetical protein	A0A182BQ76	Lactococcus_phage	2.3e-10	75.6
ARD90089.1\|5008_6475_-	DNA polymerase IV	Q6DMX4	Streptococcus_phage	1.3e-123	51.3
ARD90090.1\|6736_6925_+	hypothetical protein	NA	NA	NA	NA
ARD90091.1\|7114_7447_+	type I restriction enzyme R protein	NA	NA	NA	NA
ARD90092.1\|7478_7817_-	Transposase	NA	NA	NA	NA
ARD90093.1\|7844_8483_-	Transposase	A0A1X9I6C6	Streptococcus_phage	2.7e-97	80.7
ARD90094.1\|8565_9324_-\|transposase	transposase helper protein for IS712H	A0A059NT77	Lactococcus_phage	5.3e-137	100.0
ARD90095.1\|9335_10559_-\|transposase	transposase for insertion sequence element IS712H	A0A059NT83	Lactococcus_phage	4.9e-233	100.0
ARD90096.1\|11673_11874_+	hypothetical protein	Q9AZK6	Lactococcus_phage	2.8e-05	51.9
ARD90097.1\|12004_12205_+	cold-shock DNA-binding protein family	A0A1X9IGI9	Lactococcus_phage	1.6e-13	54.7
ARD90098.1\|12481_12682_+	cold-shock DNA-binding protein family	Q9AZD3	Lactococcus_phage	9.6e-30	97.0
ARD90099.1\|13129_13969_-	Transposase	U5P429	Shigella_phage	1.6e-46	41.0
ARD90100.1\|13986_14277_-	Transposase	NA	NA	NA	NA
ARD90101.1\|14350_15169_-	Transposase	A0A1B1P773	Bacillus_phage	1.8e-53	43.3
ARD90102.1\|15165_15537_-	Transposase	NA	NA	NA	NA
ARD90103.1\|15848_16145_+	DNA-directed DNA polymerase	NA	NA	NA	NA
ARD90104.1\|16194_16425_+	hypothetical protein	NA	NA	NA	NA
ARD90105.1\|17114_17453_-	hypothetical protein	NA	NA	NA	NA
ARD90106.1\|17644_18325_-	Transposase	A0A1X9I6C6	Streptococcus_phage	4.4e-106	81.9
ARD90107.1\|18437_18725_+\|bacteriocin	bacteriocin leader domain-containing protein	NA	NA	NA	NA
ARD90108.1\|18734_19097_+	hypothetical protein	NA	NA	NA	NA
ARD90109.1\|19283_19553_+	hypothetical protein	NA	NA	NA	NA
ARD90110.1\|19697_20273_+	HTH-type transcriptional regulator	NA	NA	NA	NA
ARD90111.1\|20272_20512_+	hypothetical protein	NA	NA	NA	NA
ARD90112.1\|20538_20739_+	isochorismatase	NA	NA	NA	NA
ARD90113.1\|20680_21163_+	Isochorismatase family protein	NA	NA	NA	NA
ARD90114.1\|21300_22650_+	pyridine nucleotide-disulfide oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	5.4e-116	50.7
ARD90115.1\|23135_23507_+	Transposase	NA	NA	NA	NA
ARD90116.1\|23503_24322_+	Transposase	A0A1B1P773	Bacillus_phage	1.4e-53	43.3
ARD90117.1\|24998_25889_+	Transposase	NA	NA	NA	NA
ARD90118.1\|25941_26757_+	Hydrolase HAD superfamily	NA	NA	NA	NA
ARD90119.1\|26878_27244_+	hypothetical protein	NA	NA	NA	NA
ARD90120.1\|27283_27559_-	hypothetical protein	NA	NA	NA	NA
ARD90121.1\|27929_28205_-	cold shock-like protein cspE	Q9AZD3	Lactococcus_phage	1.2e-27	92.4
ARD90122.1\|28281_28962_-	Transposase	A0A1X9I6C6	Streptococcus_phage	8.5e-110	84.1
ARD90123.1\|29262_29844_+	anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	1.4e-36	41.4
ARD90124.1\|29848_31774_+	anthranilate synthase component I	S4VT78	Pandoravirus	5.7e-34	36.6
ARD90125.1\|31815_32133_+	Plasmid replication protein repB	NA	NA	NA	NA
ARD90126.1\|32206_32527_+	GNAT family acetyltransferase	NA	NA	NA	NA
ARD90127.1\|32687_33155_+\|integrase	phage integrase	A0A0A8WF08	Clostridium_phage	9.2e-15	35.9
ARD90128.1\|33151_33574_-	selenium binding protein	NA	NA	NA	NA
ARD90129.1\|33903_35064_-	MFS transporter	NA	NA	NA	NA
ARD90130.1\|36709_36964_+	Transposase	NA	NA	NA	NA
ARD90131.1\|37559_37823_+\|transposase	transposase	Q6J1X2	Lactobacillus_phage	2.2e-05	33.0
ARD90132.1\|37957_38716_-\|transposase	transposase	A0A059NT77	Lactococcus_phage	2.6e-136	99.6
ARD90133.1\|38727_39951_-\|transposase	transposase	A0A059NT83	Lactococcus_phage	4.9e-233	100.0
ARD90134.1\|40176_40443_-	hypothetical protein	NA	NA	NA	NA
ARD90135.1\|40456_41254_-	plasmid partition protein	A0A1V0DZZ0	Clostridioides_phage	1.1e-20	32.6
ARD90136.1\|41397_41955_-	invertase/resolvase/recombinase	A0A0A8WIK3	Clostridium_phage	2.9e-31	43.1
ARD90137.1\|42367_42511_-	hypothetical protein	A0A182BQ76	Lactococcus_phage	1.6e-10	73.2
ARD90138.1\|42500_43967_-	DNA polymerase IV	Q6DMX4	Streptococcus_phage	6.5e-123	51.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. CP015894

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CRISPR-Cas detection and classification

Crispr_ID: CP015894_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP015894_1

2006257-2006352

Orphan

Consensus_repeat	Method
TCTTCCTCAATCTTCCCAATTCTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP015894_1

>merge|CP015894|1|2006257-2006352|CRISPRCasFinder
TTTGCCAGAATCTTCCTCAATCTTCCCAATTCTTTTAAAATAAACATTTACGCAAGTTATACTTAGTAATATTCTTCCTCAATTTTCCCAATTCTT

>CP015894|1|1|2006257-2006352|CRISPRCasFinder
TTTGCCAGAATCTTCCTCAATCTT	CCCAATTCTTTTAAAATAAACATTTACGCAAGTTATACTTAGTAATAT
TCTTCCTCAATTTTCCCAATTCTT

Protein	Signature genes	Signature genes Name	Protein_function
CP015894.1\|ARD92199.1\|2016350_2017193_+\|amino-acid-ABC-transporter-substrate-binding-protein-PAAT-family	unknown	unknown	gnl\|CDD\|270428
CP015894.1\|ARD92193.1\|2008858_2009638_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|373100
CP015894.1\|ARD92196.1\|2012157_2013027_-\|Glycerol-uptake-facilitator-related-permease-(Major-Intrinsic-Protein-Family)	unknown	unknown	gnl\|CDD\|223653
CP015894.1\|ARD92187.1\|2000115_2000574_+\|Arginine-operon-repressor	unknown	unknown	gnl\|CDD\|130592
CP015894.1\|ARD92182.1\|1992872_1994453_-\|arginine/ornithine-antiporter	unknown	unknown	gnl\|CDD\|163522
CP015894.1\|ARD92186.1\|1998353_2000048_-\|arginyl-tRNA-synthetase	unknown	unknown	gnl\|CDD\|183534
CP015894.1\|ARD92197.1\|2013198_2015490_+\|Xaa-Pro-dipeptidyl-peptidase	unknown	unknown	gnl\|CDD\|235435
CP015894.1\|ARD92181.1\|1991910_1992855_-\|carbamate-kinase	unknown	unknown	gnl\|CDD\|237071
CP015894.1\|ARD92200.1\|2017281_2018604_-\|pyridine-nucleotide-disulfide-oxidoreductase	unknown	unknown	gnl\|CDD\|180907
CP015894.1\|ARD92189.1\|2002265_2002865_-\|hypothetical-protein	unknown	unknown	unknown
CP015894.1\|ARD92185.1\|1997261_1998116_+\|transposase-for-insertion-sequence-element-IS982B	unknown	unknown	gnl\|CDD\|372648
CP015894.1\|ARD92198.1\|2015613_2016201_+\|Glutamine-amidotransferase-class-I	unknown	unknown	gnl\|CDD\|224982
CP015894.1\|ARD92195.1\|2011339_2012122_+\|metal-dependent-membrane-protease	unknown	unknown	gnl\|CDD\|376806
CP015894.1\|ARD92183.1\|1994584_1995649_-\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|179366
CP015894.1\|ARD92194.1\|2010099_2010429_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227933
CP015894.1\|ARD92190.1\|2003081_2006174_-\|DNA/RNA-helicase-SWF/SNF-family	unknown	unknown	gnl\|CDD\|350770
CP015894.1\|ARD92192.1\|2007829_2008786_-\|Beta-lactamase-family-protein	unknown	unknown	gnl\|CDD\|365903
CP015894.1\|ARD92184.1\|1995814_1997047_-\|arginine-deiminase	unknown	unknown	gnl\|CDD\|234949
CP015894.1\|ARD92188.1\|2000733_2002065_-\|UDP-N-acetylmuramate--L-alanine-ligase	unknown	unknown	gnl\|CDD\|234757
CP015894.1\|ARD92191.1\|2006382_2007024_-\|Integrase	unknown	unknown	gnl\|CDD\|271189

Protein	Function_ID	Function_description	E-value
CP015894.1\|ARD92199.1\|2016350_2017193_+\|amino-acid-ABC-transporter-substrate-binding-protein-PAAT-family	gnl\|CDD\|270428	cd13710, PBP2_TcyK, Substrate binding domain of an ABC transporter TcyJKLMN; the type 2 periplasmic binding protein fold. This group contains periplasmic cystine-binding domain (TcyK) of an ATP-binding cassette transporter from Bacillus subtilus and its closely related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.80736e-84
CP015894.1\|ARD92193.1\|2008858_2009638_-\|hypothetical-protein	gnl\|CDD\|373100	pfam14507, CppA_C, CppA C-terminal. This is the C-terminal domain of the CppA protein found in species of Streptococcus. CppA is a putative C3-glycoprotein degrading proteinase, involved in pathogenicity. It is often found associated with pfam14506.	1.10613e-24
CP015894.1\|ARD92196.1\|2012157_2013027_-\|Glycerol-uptake-facilitator-related-permease-(Major-Intrinsic-Protein-Family)	gnl\|CDD\|223653	COG0580, GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism].	2.51202e-67
CP015894.1\|ARD92187.1\|2000115_2000574_+\|Arginine-operon-repressor	gnl\|CDD\|130592	TIGR01529, Arginine_repressor., arginine repressor. This model includes most members of the arginine-responsive transcriptional regulator family ArgR. This hexameric protein binds DNA at its amino end to repress arginine biosyntheis or activate arginine catabolism. Some species have several ArgR paralogs. In a neighbor-joining tree, some of these paralogous sequences show long branches and differ significantly in an otherwise well-conserved C-terminal region motif GT[VIL][AC]GDDT. These paralogs are excluded from the seed and score in the gray zone of this model, between trusted and noise cutoffs. [Amino acid biosynthesis, Glutamate family, Regulatory functions, DNA interactions].	8.41328e-60
CP015894.1\|ARD92182.1\|1992872_1994453_-\|arginine/ornithine-antiporter	gnl\|CDD\|163522	TIGR03810, arginine-ornithine_antiporter, arginine-ornithine antiporter. Members of this protein family are the arginine/ornithine antiporter, ArcD. This exchanger of ornithine for arginine occurs in a system with arginine deiminase, ornithine carbamoyltransferase, and carbamate kinase, with together turn arginine to ornithine with the generation of ATP and release of CO2. [Transport and binding proteins, Amino acids, peptides and amines].	4.25473e-157
CP015894.1\|ARD92186.1\|1998353_2000048_-\|arginyl-tRNA-synthetase	gnl\|CDD\|183534	PRK12451, PRK12451, arginyl-tRNA synthetase; Reviewed.	0
CP015894.1\|ARD92181.1\|1991910_1992855_-\|carbamate-kinase	gnl\|CDD\|237071	PRK12353, PRK12353, putative amino acid kinase; Reviewed.	7.27953e-178
CP015894.1\|ARD92200.1\|2017281_2018604_-\|pyridine-nucleotide-disulfide-oxidoreductase	gnl\|CDD\|180907	PRK07251, PRK07251, FAD-containing oxidoreductase.	1.09567e-150
CP015894.1\|ARD92197.1\|2013198_2015490_+\|Xaa-Pro-dipeptidyl-peptidase	gnl\|CDD\|235435	PRK05371, PRK05371, x-prolyl-dipeptidyl aminopeptidase; Provisional.	0
CP015894.1\|ARD92185.1\|1997261_1998116_+\|transposase-for-insertion-sequence-element-IS982B	gnl\|CDD\|372648	pfam13612, DDE_Tnp_1_3, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contains three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	3.47425e-25
CP015894.1\|ARD92198.1\|2015613_2016201_+\|Glutamine-amidotransferase-class-I	gnl\|CDD\|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	3.34246e-89
CP015894.1\|ARD92195.1\|2011339_2012122_+\|metal-dependent-membrane-protease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	3.89843e-08
CP015894.1\|ARD92183.1\|1994584_1995649_-\|ornithine-carbamoyltransferase	gnl\|CDD\|179366	PRK02102, PRK02102, ornithine carbamoyltransferase; Validated.	0
CP015894.1\|ARD92194.1\|2010099_2010429_-\|hypothetical-protein	gnl\|CDD\|227933	COG5646, COG5646, Uncharacterized conserved protein [Function unknown].	1.81818e-27
CP015894.1\|ARD92190.1\|2003081_2006174_-\|DNA/RNA-helicase-SWF/SNF-family	gnl\|CDD\|350770	cd18012, DEXQc_arch_SWI2_SNF2, DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins. Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	6.26854e-94
CP015894.1\|ARD92192.1\|2007829_2008786_-\|Beta-lactamase-family-protein	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	3.4174e-51
CP015894.1\|ARD92184.1\|1995814_1997047_-\|arginine-deiminase	gnl\|CDD\|234949	PRK01388, PRK01388, arginine deiminase; Provisional.	0
CP015894.1\|ARD92188.1\|2000733_2002065_-\|UDP-N-acetylmuramate--L-alanine-ligase	gnl\|CDD\|234757	PRK00421, murC, UDP-N-acetylmuramate--L-alanine ligase; Provisional.	0
CP015894.1\|ARD92191.1\|2006382_2007024_-\|Integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	7.384e-11

>CP015894.1|ARD92190.1|2003081_2006174_-|DNA/RNA-helicase-SWF/SNF-family
MPARVRSEGIALYAKGFLNDPIETDLKLTAEIDGEEVSYDLDGAQDSCTCSIFQQNHRYCKHIAAIEEYLKNQDKGSLETKDKETKGAERGLYNENIAFLDAVNGETQLNFSTDQYSIEVQIEDNSQLYDYFSMDYFLYFDLKLKSKNLGRSYVIKDIPYFLRALKNYSQYSLGSLHYIDLFFDNFDEASQEFLSFLLKIDGKSDEALTKSLYIKNGRYLNIPFLFLEEAMDLVSALEVYQLKIIGRTVNYFTFIPLDNDSEIFKFKVESQQDYIELSLFSEDYHNFYDYSLLYDNNVFYKLSQEQRRLLLVLDKQFAQKSKIKFSYSEKDKLAQALQQLSTLGKIEAPEHFVVKPFDAKFTFDLLDEKTLSLAMKFDYGTFSIDSFHDLETLEFSRDLRKEQKIFALMERLQFAKAFNSTLEITEHLSENFFLKILPSFQKLGQIELSPTLRNMRMDEVPEIHIDSQGGLLDISFNIPHVEDGEFANVIAKLQENAEFYISESGKFYHFNEKFDRLKAALHELDDQFVIQGSSLHVNINRSFQISKIFEKISGASFSEKFKSLYQHLTHPEEFPYEKPEHIKASLRSYQETGVRWMSMLSHYNLGGILADDMGLGKTVQAITFILSNLKKDESVLITAPASLTYNWASEFEKFTDEIDFVVIDGNKADRTKEIQENHQIYITSYGSFLKDFEDYQDKKLNYLLLDEAQVVKNYSSKTNKSLSALNVEHTFALSGTPLENRIEEIWAIFQVVMPGFLPKREKFNKMEPSVISRLIQPFIMRRKKEDVLEELPEKMEITVYNQLADDQKVIYLAQLELMQKQVLEMDNAALSRSRIEILAGITRLRQICNTPALFMDDYKGSSGKLERLRELLAQIKDSGHRPLIFSQFTKVFPHIEKLMEEQEMTAYKLTGSTPIKDRLSMVQAFNAGSRDAFLVSLKAGGVGLNLTSADVVILVDLWWNPAVEEQAIARAHRMGQKNTVEVIRLITQGTIEEKIMEIQERKKDLIANVLEGDTVDKVLSEAEIREILGV
>CP015894.1|ARD92189.1|2002265_2002865_-|hypothetical-protein
MVERRVVFPVIGDDEVLQKDTRVIFTNQQLLTRNPSLQDEASIETSKSKTDAKRPESFKPYKAKTSFSTQHRPLNSNHAGVSSYDKMPKKTSVDESKERAKRAAATLPKPPKQYVSPLERDKEDLTVRRSTSAILNKRPSTNDNPIRVMKKQGMNVSDAVAKNGSGMKKATPHGGAANDTQKGSYFENKRKNIFDRGIV
>CP015894.1|ARD92188.1|2000733_2002065_-|UDP-N-acetylmuramate--L-alanine-ligase
MEKTYHFTGIKGSGMSALALMLHQMGKNVQGSDSTDYFFTQRGLEQVGVPLLPFDEKNIKPEFELIVGNAFRDDNNVEIAFAHKKGFPFKRYHEFLGHFMEDFTSIGVAGAHGKTSTTGMLAHVMSNIVDTSYLIGDGTGRGNAGSEYFVFESDEYERHFMPYHPEYTIMTNIDFDHPDYFEGIEDVTSAFQDYANNIKKGIFAYGEDVNLRKLSAKAPIYYYGFEANDDYRAENLIRSTRGSSFDAYFRGEKIGHFVVPTYGKHNVLNALSVVAVCHNLGLDMTDVADHLLTFRGVKRRFTEKKVGETVIIDDFAHHPTEIEATLDAARQKYPDREIVAVFQPHTFTRTIAFADEFAEVLDHADTVYLAQIYGSAREVDHHEITAQDLADKVRKPAKVIELDNVSPLLDHDRGVYVFMGAGNIQKYEIAFEKLLSQTSTNLQ
>CP015894.1|ARD92187.1|2000115_2000574_+|Arginine-operon-repressor
MKRDKRLEIIKEIVTNNKISTQEELQSLLLERGVEVTQATLSRDIRKLNIIKKRDKGESFYSFLTSGNSKINSDLQLYFYNFVISAKSVGALVVIRTKLGEADVLANALDDERDIRTDILGTIAGADTLLVICASEKAANILTAEIKYILLG
>CP015894.1|ARD92186.1|1998353_2000048_-|arginyl-tRNA-synthetase
MDEKQLVSQALSAAIDGVLGVEQIAAIIEKPKSSDLGDLAFPAFQLAKTLRKSPQIIAGEIAEKIDTKGFEKVIAVGPYVNFFLDKNATASEVIREVLTEGEHYGDANIGEGGNVPIDMSAPNIAKPFSIGHLRSTVIGDSIAKIYEKLGYQPIKINHLGDWGKQFGLLITAYKKYGDEATITANPIDELLKLYVKINAEAKEDPEVDEEGRQWFLKMEQGDEEALRIWKWFSDVSLIEFNRIYGKLGVTFDHFMGESFYSDKMDAIVEDLENKNLLHESKGALIVDLEKYNLNPALIKKTDGATLYITRDLATAAYRKKTFNFVKSLYVVGGEQTNHFKQLKAVLKEAGYDWSDDMVHVPFGMVTQGGKKFSTRKGHVVKLEMALDEAVDRAEKQIEAKNPNLENKEEVAKQVGVGAVKFYDLKTDRNNGYDFDLDEMVSFEGETGPYVQYAHARIQSILRKANRKVNIDNISLVVSDAEAWEIVKALKEFPNIVKRAADNYEPSIIAKYAISLAQAFNKYYAHVRILEDDAQLDGRLALISATSIVLKEALRLLGVAAPENM
>CP015894.1|ARD92185.1|1997261_1998116_+|transposase-for-insertion-sequence-element-IS982B
MTYNSTLPKVFVYLLTTIETLYQTRVPLEVQNRKNVHLATSGCLVIACYLWGVLHFSETLKAKHQLAQSLFPNFLEYSRFVRRCNALLPSIQVIRQAIVFKEVEGMSVSIIDSFPIPLCQPIRNFKSKVLGDYANVGYNATKGQYFYGCKCHALVSESGYVIDYTITPASMADSSMTEEVLSQFGTPTVLGDMGYLGQSLHDRLELKGIDLITPVRKNMKQKKILFPNFSKRRKVIERVFSFLTNLGAERCKSRSPQGFQLKLEMILLAYSLLLNQLNHWNQRL
>CP015894.1|ARD92184.1|1995814_1997047_-|arginine-deiminase
MNNGINVNSEIGKLKSVLLHRPGAEVENITSDTMKQLLFDDIPYLKIAQKEHDFFAQTLRDNGAETVYIENLATEVFEKSSETKEEFLSHLLHEAGYRPGRTYDGLTEYLTSMPTKDMVEKVYAGVRKNELDIKRTALSDMAGSDAENYFYLNPLPNAYFTRDPQASMGVGMTINKMTFPARQPESLITEYVMANHPRFKDTPIWRDRNHTTRIEGGDELILNKTTVAIGVSERTSSKTIQNLAKELFANPLSTFDTVLAVEIPHNHAMMHLDTVFTMINHDQFTVFPGIMDGAGNINVFILRPGQDGEVEIEHLTDLKAALKKVLNLSELDLIECGAGDPIAAPREQWNDGSNTLAIAPGEIVTYDRNYVTVELLKEHGIKVHEILSSELGRGRGGARCMSQPLWREDL
>CP015894.1|ARD92183.1|1994584_1995649_-|ornithine-carbamoyltransferase
MTSPLITKAEVNSVFQGRSLLAEKDFTPDEINYLVDFGLHLKALKQQNIPHHYLEGKNIALLFAKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGFSQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENFGYLKGLTLVYVGDGRNNMANSLIVTGSMLGVNVHIVAPDSLHPSKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYSDVWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGKLIFMHCLPSFHDTETEYGKEIKEKYGLTEMEVTDEVFRSKYARQFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK
>CP015894.1|ARD92182.1|1992872_1994453_-|arginine/ornithine-antiporter
MDAENKKGIGLAALVAIIVSGAIGGGVFNLSNDLATNASPGGVVISWIVIGFGILMLVLSLNHLVVNKPELSGVSDYARAGFGNMVGFISGWGYWLSAWAGNIAFAVLMMTAVDYFFPGVFQAKNGSLTILSVIVVSIVSWGLTLLVMRGVEGAAAINAIVLVAKLIPLFVFVIAGIVTFKAGVFSAHFWQNFVANTNADGVIKSLTWSNMTGGDLFSQVKGSLMVMIWVFVGIEGAAMMGDRAKRKSDAGKASILGLIALLVIYILLSLLPFGFMSQQELANTGQPGLVHILNAMVGGWGGSLMAIGLVISLLGAWLSWTMLPVEATQQLSEQKLLPSWFGKLNDKGAPKNSLLLTQMIVQIFLIVTYFVADAYNVFVYLCTAVIMICYALVGLYLFKLGIQEKKTSNIIIGFIAAAFQILALYYSGWQFVWLSLILYAVGFILYALGKKEYGTKMSTAELIATFILTVLGILAVFGVYGNWLGLQDALGIDGNTLLVAVVPLIVVTFIVYFVVRSDINKKGIKN
>CP015894.1|ARD92181.1|1991910_1992855_-|carbamate-kinase
MVSRIVVALGGNAILTKDPSAAAQKKALEVTAEQLMPLIKDNDRQMVVTHGNGPQVGNLLLQQLGSDSEKNPAMPLDTVGAMTQGEIGFWTVQAFTRAMANNGLERYPVISAVTQTLVDENDPAFKNASKPIGPFYTEEQLPEIKKQFPDWELMEDAGRGYRRVVPSPKPLEIIEAKAFGPILESGSLLIASGGGGIPVIKDGNGYKGVEAVIDKDFSAAKLAEMVGADELLILTAVDNVFVNFNKPNQKKLETVTMAEMKAYIKEGQFAAGSMLPKVEAAMEFVTRTGRPATITSLENLEDFLNNDSGTKIIP
>CP015894.1|ARD92191.1|2006382_2007024_-|Integrase
MEVLLNHMKEFEKTQNTKQEDCVRKRLFIEFTYLNGNRYGEGAGLKFSTVNHGGIWIKDQYSRKSSVKNPINKQTKTLTSRRIKAFENDDTRSKEIIQWFLDHNNSGINDDYIFVRKNGHLLSDDTMNRYLHRFEKQMPDKLSSSFVMHSLRHSYITRRAEAGDTETEIMAKVGHANPNLVHTLYTHVRDTLKFDEQKKFKKQPRLLKIGKSA
>CP015894.1|ARD92192.1|2007829_2008786_-|Beta-lactamase-family-protein
MKNQQEFLAMIEDYLERDVFPGVNFAILEGEEVSEYLFGKAALIPEPIALTPGKKWDLASLTKVIGTGTAVIDLVLAGKLELDAPLQKYYAKFTDSTVSLRQLLTHTSGIDPYIPNRDKLGFFELTEAINQIRVTDDKSFKYTDINFILLGFLLEEYYDESLDYIFNKNIFKNWEMKQTSFGSVENAVPTSQNIPLGTVHDPKAQVLKNHCGSAGLFSTLSDMILFSQAYFREEKYLELLKNYADGAKERSLAWDLPAENNDWLLHTGYTGTFILINPRIKKAVVFLSNRVHLKDNREKWIEERDRLIKFLINHLSLD
>CP015894.1|ARD92193.1|2008858_2009638_-|hypothetical-protein
MSEIINHITAFQPVYRVLHREENLDFYRGVLGFKVLVEEGAMVWLGGHEAKKDRFQLEESPGFHPVEGLKKHGQTVIKANSSEIEQLIVRNLDKIAKIYQGKNGLAFTALSPEAGLFLVSSDSLTDLPALTEINKSEIKLNLDKNFKGLSDFEITAMNLNVADKSIIEFYESVFDLKAIDGKIEFPFVTLTLNVEESEDLTAGTDEVLDLEFLIFMIDKDFDLKAFANQFSEANGTYIDASAKTFFLEVPDHAELWFVK
>CP015894.1|ARD92194.1|2010099_2010429_-|hypothetical-protein
MEFEEFFINNQLMKLIRETVLSIFPEAQERISYGMPAWFNGKTVLIYAQPQKHHLGIYPRPNFIEKHLEVLKQQYECSKGTIKVPYGIEHGELRKLVSDVINWNLTHFT
>CP015894.1|ARD92195.1|2011339_2012122_+|metal-dependent-membrane-protease
MNIEKLQFLAKYRWIIVLILALIFSGLSVSIFHLPFLMTALVLSVIGLIFAYHKSVWLVLFILSNLPMLVSTIFASQHHFSTLDTIIFFIIFIFTIISSYLIARKAELIPKLSWKYFPPLRIILGFVLLFLVSILTGIFAQIFNQSPTTTNQESLNELQKVIPIAVFATQTLAASFLEELVYRVGIFELIFKNQKYFAFLTTMLLFAFMHGPTDVYSWLTYGLMSLVLTGLYAKYRNFYLNMSVHFLWNLFGLVIALMVK
>CP015894.1|ARD92196.1|2012157_2013027_-|Glycerol-uptake-facilitator-related-permease-(Major-Intrinsic-Protein-Family)
MDVTWTVKYITEFVGTALLIIMGNGAVANVELKGTKAHAQSWLIIGWGYGLGVMLPAVAFGNITSQINPAFTLGLAASGLFPWAHVAQYIIAQVLGAMFGQLLIVMVYRPYYLKTQNPNAILGTFSTIDNVDDNSEKTRLGATINGFLNEFLGSFVLFFGAVAATNIFFGSQSITWMTNYLKGQGADVSSSDVMNQIWVQASGASASKMIAHLFLGFLVLGLVVALGGPTGPGLNPARDFGPRLVHSLLPKSVLGEAKGSSKWWYAWVPVLAPILASLAAVALFKMIYL
>CP015894.1|ARD92197.1|2013198_2015490_+|Xaa-Pro-dipeptidyl-peptidase
MRFNHFSIVDKNFDEQLAELDQLGFRWSVFWDEKKILKDFLIQSPSDMTDLQATAELDVIEFLKSSIELDWEIFWNIALQLLDFVPNFDFEIGKAFEYAKNSNLPQIEAEMTTENIISAFYYLLCTRRKNGMILVEHWVSEGLLPLDNHYHFFNDKSLATFDSSLLEREVLWVESPVDSEQRGENDLIKIQIIRPKSTEKLPVVMTASPYHLGINDKANDLALHDMNVELEEKTSHEIHVEQKLPQKLSAKAKELPIVDKAPYRFTHGWTYSLNDYFLTRGFASIYVAGVGTRSSDGFQTSGDYQQIYSMTAVIDWLNGRARAYTSRKKTHEIKASWANGKVAMTGKSYLGTMAYGAATTGVEGLEVILAEAGISSWYNYYRENGLVRSPGGFPGEDLDVLAALTYSRNLDGADFLKGNAEYEKRLAEMTAALDRKSGDYNQFWHDRNYLINTDKVKADVLIVHGLQDWNVTPEQAYNFWKALPEGHAKHAFLHRGAHIYMNSWQSIDFSETINAYFVAKLLDRDLNLNLPPVILQENSKDQVWTMMNDFGANTQIKLPLGKTAVSFAQFDNHYDDETFKKYSKDFNVFKKDLFENKANEAVIDLELPSMLTINGPVELELRLKLNDTKGFLSAQILDFGQKKRLEDKARVKDFKVLDRGRNFMLDDLVELSLVESPYQLITKGFTNLQNQNLLTVSDLKADEWFTIKFELQPTIYHLEKADKLRVILYSTDFEHTVRDNRKVTYEIDLSQSKLIIPIESVKN
>CP015894.1|ARD92198.1|2015613_2016201_+|Glutamine-amidotransferase-class-I
MIVLPVDKTENIKNYLPLVDKIVLTGGADVSPYLYGEEPHAQLGTTDPIRDRFELAAIKAALEANKPILGVCRGLQLLNVYFGGTLYQDLSLTSSQIKHLQSPTPQEVPTHHISVEKESSLGFLPENYMVNSFHHQVIKDLGQGLQAIAHGNDGLVEAIENKEKHVLAVQWHPECTWETENFDKKIFEIFANGDI
>CP015894.1|ARD92199.1|2016350_2017193_+|amino-acid-ABC-transporter-substrate-binding-protein-PAAT-family
MKKIKLLTLATLGIASIGLLAACSSKDNSSSKSTDKVTTVTVATSAASVPYEYSENGKMTGFEYDILKAADKDMKDYKFEFKVYEDSAILAALDGGRAQIAANNFGKTKARSEKYLFSYPVRQGIDAIFSTSKENITKISQLAGKTTEIPAGTNYGDMFESWNKNHPDKKIDVKYSQRPLADRLSAIASGQIDFLFASKAPAENLIRQHAITGLVDTVPTDLNKQSEFKTYDYFILDNSQTKLQKDLNAELKKLYENGTLKELSEKYFHDSHIPAADQFK
>CP015894.1|ARD92200.1|2017281_2018604_-|pyridine-nucleotide-disulfide-oxidoreductase
METRHFKNIIIGFGKAGRALAKSLSKNGEEALIIERDQAMYGGTCPNVGCAPSKTLIVAGQKNMNFSEAMTTKYKVREILHNAAYHGAADEALVYVMDGLARFINSKTVEVVNGENVTQVIGERIFINTGATPIIPEIEGIHEAKNVVTSEGAMELSELPKKLVIIGAGYIGLEFAGMFNKFGSEVTILEPHATFLPKEDEDISNEIYKDLVAAGVEIQLGVEIERITDSEVFAGGKIYPADKILIATGRRPNIKDLDLEKADVELSENGYIKVDDDLKTTAQNIWALGDVRGGGQFYYLSTDDFRIVNNQLFGDHSRKLSDRKLVPYSVFISPTLSRIGLDEKQAKEAGVNYRLFKMAAAPIVKAKVVQDTRGLLKALVDPNTDEILGATLYHEDSHEVINLVSLAMKMHTPYQVLRDQIFTHPTMGEGLNDLFQNEVK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

20731 : 83480

Lactococcus_phage(18.75%)

integrase,transposase,tRNA

attL 64110:64128|attR 82569:82587

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD90357.1\|20731_22000_+\|tRNA	tRNA(Ile)-lysidine synthetase	NA	NA	NA	NA
ARD90358.1\|21980_22532_+	hypoxanthine phosphoribosyltransferase	A0A1V0SEQ1	Hokovirus	1.4e-09	29.7
ARD90359.1\|22737_24828_+	Cell division protein FtsH	G8DDJ2	Micromonas_pusilla_virus	1.6e-106	49.2
ARD90360.1\|25895_27719_+	Phosphotransferase system mannitol-specific IIBC component	NA	NA	NA	NA
ARD90361.1\|27778_29641_+	transcriptional regulator mtl operon mtlR	NA	NA	NA	NA
ARD90362.1\|29712_30441_-\|transposase	transposase helper protein for IS712H	A0A059NT77	Lactococcus_phage	6.0e-130	99.2
ARD90363.1\|30385_31696_-\|transposase	transposase for insertion sequence element IS712H	A0A059NT83	Lactococcus_phage	3.1e-225	99.7
ARD90364.1\|31918_32350_+	PTS system mannitol-specific IIA component	NA	NA	NA	NA
ARD90365.1\|32498_33665_+	mannitol-1-phosphate 5-dehydrogenase	NA	NA	NA	NA
ARD90366.1\|34477_34720_+	membrane protein	NA	NA	NA	NA
ARD90367.1\|34813_36436_-	Sulfate transporter	NA	NA	NA	NA
ARD90368.1\|36645_37167_+	acetyltransferase	A0A1P8CWJ6	Bacillus_phage	1.0e-30	42.1
ARD90369.1\|37628_38804_+	aromatic amino acid aminotransferase	NA	NA	NA	NA
ARD90370.1\|38901_39657_+	DNA repair protein RecO	NA	NA	NA	NA
ARD90371.1\|39808_41227_-	dihydrolipoamide dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	3.0e-40	27.0
ARD90372.1\|41445_43032_-	pyruvate dehydrogenase complex E2 component	NA	NA	NA	NA
ARD90373.1\|43024_44005_-	pyruvate dehydrogenase E1 component beta subunit	NA	NA	NA	NA
ARD90374.1\|44007_45132_-	acetoin dehydrogenase complex E1 component alpha subunit	NA	NA	NA	NA
ARD90375.1\|45220_46222_-	lipoate-protein ligase	NA	NA	NA	NA
ARD90376.1\|46414_47269_-	glycerophosphodiester phosphodiesterase	A0A0S2MYI4	Enterococcus_phage	7.8e-12	31.4
ARD90377.1\|47347_48007_-	Metal-dependent phosphohydrolase HD superfamily	A0A1S5XYU7	Kurlavirus	1.2e-15	33.3
ARD90378.1\|48047_48374_-	hypothetical protein	NA	NA	NA	NA
ARD90379.1\|48430_49321_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD90380.1\|49473_50499_-\|tRNA	tryptophanyl-tRNA synthetase II	NA	NA	NA	NA
ARD90381.1\|50997_51435_+	osmotically inducible protein C	NA	NA	NA	NA
ARD90382.1\|51596_52910_+	Amino acid permease	NA	NA	NA	NA
ARD90383.1\|52988_53984_-	glycerol-3-phosphate acyltransferase PlsX	NA	NA	NA	NA
ARD90384.1\|54086_54899_-	Hydrolase HAD superfamily	NA	NA	NA	NA
ARD90385.1\|55426_57064_-	ATPase component of ABC transporter	A0A2K9L3Z8	Tupanvirus	4.8e-50	25.9
ARD90386.1\|57564_57819_+	hypothetical protein	NA	NA	NA	NA
ARD90387.1\|57937_58762_-	Short chain dehydrogenase	NA	NA	NA	NA
ARD90388.1\|58921_59503_-	Transcriptional regulator	NA	NA	NA	NA
ARD90389.1\|59690_60173_-	hypothetical protein	NA	NA	NA	NA
ARD90390.1\|60429_61710_-	O-acetyl-L-homoserine sulfhydrolase / O-acetyl-L-serine sulfhydrolase	A0A2I2L687	Orpheovirus	2.5e-09	26.5
ARD90391.1\|61962_62796_-	Short-chain dehydrogenase	NA	NA	NA	NA
ARD90392.1\|63144_64035_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
64110:64128	attL	NA	NA	NA	NA
ARD90393.1\|64940_66203_-\|integrase	phage integrase	Q9AZK8	Lactococcus_phage	1.6e-53	34.5
ARD90394.1\|66285_66546_-	phage protein	NA	NA	NA	NA
ARD90395.1\|66538_67141_-	Plasmid replication protein repB	NA	NA	NA	NA
ARD90396.1\|67291_67900_-	hypothetical protein	NA	NA	NA	NA
ARD90397.1\|67896_68973_-	FtsK/SpoIIIE family	NA	NA	NA	NA
ARD90398.1\|68972_69293_-	hypothetical protein	NA	NA	NA	NA
ARD90399.1\|69442_69874_-	hypothetical protein	NA	NA	NA	NA
ARD90400.1\|70151_71462_+	hypothetical protein	NA	NA	NA	NA
ARD90401.1\|71458_71809_+	hypothetical protein	NA	NA	NA	NA
ARD90402.1\|71774_72395_+	hypothetical protein	NA	NA	NA	NA
ARD90403.1\|72412_73582_-	Modification methylase ScrFIA	Q6DMX0	Streptococcus_phage	1.1e-152	70.2
ARD90404.1\|73746_74562_-	Type II restriction enzyme ScrFI	NA	NA	NA	NA
ARD90405.1\|74580_75663_-	Modification methylase ScrFIB	A0A0E3DF50	Bacillus_phage	7.0e-50	36.3
ARD90406.1\|75666_76134_-	orfX	NA	NA	NA	NA
ARD90407.1\|76331_76481_-	LSU ribosomal protein L33P	NA	NA	NA	NA
ARD90408.1\|76510_76684_-	LSU ribosomal protein L32P	NA	NA	NA	NA
ARD90409.1\|77045_78827_+	Lead cadmium zinc mercury transporting ATPase	E4ZFI9	Streptococcus_phage	1.7e-64	29.6
ARD90410.1\|79870_80656_-	chromosome partitioning protein parA	NA	NA	NA	NA
ARD90411.1\|80710_81970_-	Chromosome segregation helicase ATPase AAA family	A0A127AWE7	Bacillus_phage	2.5e-91	45.3
ARD90412.1\|82013_82502_-	Acetyltransferase GNAT family	A0A1B2ICF0	Erwinia_phage	1.1e-05	50.9
ARD90413.1\|82589_83480_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
82569:82587	attR	NA	NA	NA	NA

DBSCAN-SWA_2

112233 : 168312

Bacillus_phage(37.5%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD90443.1\|112233_113073_+\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	1.6e-49	41.4
ARD90444.1\|113941_115252_+\|transposase	transposase for insertion sequence element IS712H	A0A059NT83	Lactococcus_phage	3.1e-225	99.7
ARD90445.1\|115196_115925_+\|transposase	transposase helper protein for IS712H	A0A059NT77	Lactococcus_phage	6.0e-130	99.2
ARD90446.1\|116071_117112_+	hypothetical protein	NA	NA	NA	NA
ARD90447.1\|118057_119254_+	argininosuccinate synthase	NA	NA	NA	NA
ARD90448.1\|119282_120662_+	argininosuccinate lyase	NA	NA	NA	NA
ARD90449.1\|120678_121875_-	multidrug resistance efflux pump	NA	NA	NA	NA
ARD90450.1\|122067_122643_+	transcriptional regulator TetR family	NA	NA	NA	NA
ARD90451.1\|122799_123153_+	ribonuclease P	NA	NA	NA	NA
ARD90452.1\|123176_123959_+	preprotein translocase subunit	NA	NA	NA	NA
ARD90453.1\|124046_124961_+	RNA-binding protein R3H domain protein	NA	NA	NA	NA
ARD90454.1\|125092_125227_+	LSU ribosomal protein L34P	NA	NA	NA	NA
ARD90455.1\|125403_126315_+	aryl-alcohol dehydrogenase	NA	NA	NA	NA
ARD90456.1\|126384_126699_+	Transcriptional regulator xre family	NA	NA	NA	NA
ARD90457.1\|126761_127442_+	hypothetical protein	NA	NA	NA	NA
ARD90458.1\|127736_128003_+	hypothetical protein	NA	NA	NA	NA
ARD90459.1\|128002_128434_+	RNase H-like ribonuclease	NA	NA	NA	NA
ARD90460.1\|128534_128858_+	hypothetical protein	NA	NA	NA	NA
ARD90461.1\|128887_129439_-	hypothetical protein	NA	NA	NA	NA
ARD90462.1\|129528_130269_-	carbonyl reductase	NA	NA	NA	NA
ARD90463.1\|130288_130600_-	hypothetical protein	NA	NA	NA	NA
ARD90464.1\|130609_131395_-	oxidoreductase dltE	NA	NA	NA	NA
ARD90465.1\|131513_132059_+	transcriptional regulator TetR family	NA	NA	NA	NA
ARD90466.1\|132124_134068_-	14-Alpha-glucan branching enzyme	NA	NA	NA	NA
ARD90467.1\|134187_134508_-	hypothetical protein	NA	NA	NA	NA
ARD90468.1\|135330_135591_+	Transposase	A0A1P8CWP5	Bacillus_phage	8.4e-10	37.6
ARD90469.1\|135602_136442_+\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	1.6e-49	41.4
ARD90470.1\|136570_137110_+	HTH-type transcriptional regulator	NA	NA	NA	NA
ARD90471.1\|137565_142410_+	hypothetical protein	NA	NA	NA	NA
ARD90472.1\|143767_144898_+	Cell surface protein C-terminal membrane anchored	NA	NA	NA	NA
ARD90473.1\|144970_145258_+	hypothetical protein	NA	NA	NA	NA
ARD90474.1\|145309_146017_+	secreted protein	NA	NA	NA	NA
ARD90475.1\|146073_146964_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD90476.1\|147112_149854_+	cell surface protein	NA	NA	NA	NA
ARD90477.1\|149829_150009_+	hypothetical protein	NA	NA	NA	NA
ARD90478.1\|149965_150280_+	Transcriptional regulator xre family	A0A1S5SC02	Streptococcus_phage	2.8e-07	40.0
ARD90479.1\|150568_151717_-\|tRNA	queuine tRNA-ribosyltransferase	A0A1B1IVQ4	uncultured_Mediterranean_phage	1.9e-85	42.9
ARD90480.1\|151916_152606_+	hypothetical protein	NA	NA	NA	NA
ARD90481.1\|152660_153839_-	Transporter MF superfamily	NA	NA	NA	NA
ARD90482.1\|154020_154458_-	CoA-binding protein	NA	NA	NA	NA
ARD90483.1\|154594_155380_+	DNA/RNA non-specific endonuclease	NA	NA	NA	NA
ARD90484.1\|155548_155758_+	hypothetical protein	NA	NA	NA	NA
ARD90485.1\|155769_156009_+	hypothetical protein	NA	NA	NA	NA
ARD90486.1\|156206_157787_+	heme/copper-type cytochrome/quinol oxidase subunit 1	NA	NA	NA	NA
ARD90487.1\|157916_159131_+	L-aspartate aminotransferase apoenzyme	NA	NA	NA	NA
ARD90488.1\|159282_160071_+	transcriptional repressor CodY	NA	NA	NA	NA
ARD90489.1\|160348_160654_+\|tRNA	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C	NA	NA	NA	NA
ARD90490.1\|160653_162114_+\|tRNA	aspartyl/glutamyl-tRNA amidotransferase subunit A	NA	NA	NA	NA
ARD90491.1\|162138_163572_+\|tRNA	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B	NA	NA	NA	NA
ARD90492.1\|163695_165195_+	amidase	NA	NA	NA	NA
ARD90493.1\|165259_166600_-	Na+ driven multidrug efflux pump MatE family	NA	NA	NA	NA
ARD90494.1\|166780_166978_-	cold-shock DNA-binding protein family	Q9AZD3	Lactococcus_phage	3.5e-24	83.1
ARD90495.1\|167096_167630_+	5-formyltetrahydrofolate cyclo-ligase family protein	NA	NA	NA	NA
ARD90496.1\|167619_168312_+\|protease	Membrane-associated serine protease	NA	NA	NA	NA

DBSCAN-SWA_3

410607 : 420738

uncultured_virus(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD90718.1\|410607_410925_+	Thiol-disulfide isomerase and thioredoxin	A0A0K2FIM3	Achromobacter_phage	9.0e-06	31.9
ARD90719.1\|411030_411657_+\|tRNA	phenylalanyl-tRNA synthetase beta chain	NA	NA	NA	NA
ARD90720.1\|411818_413159_+	NADH oxidase H2O-forming	NA	NA	NA	NA
ARD90721.1\|413249_413639_+	single-stranded DNA-binding protein,ssbA	A0A218MNB4	uncultured_virus	1.3e-22	48.6
ARD90722.1\|413757_414042_+	Co-chaperonin GroES (HSP10)	A0A221S386	uncultured_virus	2.3e-13	43.0
ARD90723.1\|414128_415757_+	Chaperonin GroEL (HSP60 family)	A0A219YK78	uncultured_virus	2.2e-156	56.8
ARD90724.1\|415808_416621_-	Metal-dependent hydrolase of the beta-lactamase superfamily I	A0A0C5AJ83	Bacteriophage	1.5e-33	38.1
ARD90725.1\|416810_418238_-	PAS/PAC sensor signal transduction histidine kinase	W8CYF6	Bacillus_phage	3.9e-32	32.9
ARD90726.1\|418230_418932_-	DNA-binding response regulator OmpR family (Rec-wHTH domains)	W8CYM9	Bacillus_phage	1.2e-42	39.7
ARD90727.1\|419109_419745_+	thymidylate kinase	M1PSC7	Streptococcus_phage	1.6e-73	66.0
ARD90728.1\|419877_420738_+	DNA polymerase III delta prime subunit	M1NSC1	Streptococcus_phage	3.1e-64	44.8

DBSCAN-SWA_4

521675 : 576441

Bacillus_phage(33.33%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD90826.1\|521675_522566_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD90827.1\|522858_523236_+	hypothetical protein	NA	NA	NA	NA
ARD90828.1\|523344_524490_+	Cysteine desulfurase / Selenocysteine lyase	NA	NA	NA	NA
ARD90829.1\|524639_525518_+	Gamma-glutamyl-diamino acid-endopeptidase extracellular cell-wall-bound	NA	NA	NA	NA
ARD90830.1\|525574_527224_-	Oligopeptide-binding protein	NA	NA	NA	NA
ARD90831.1\|527407_528340_-	cysteine synthase	A0A1X9I5K7	Streptococcus_phage	4.0e-118	71.1
ARD90832.1\|528558_529644_+	N-acetylglucosaminidase	A0A223LD43	Bacillus_phage	2.1e-09	34.1
ARD90833.1\|529679_530312_-	Metallo-beta-lactamase family protein	A0A1X9I5D3	Streptococcus_phage	1.7e-48	45.3
ARD90834.1\|530312_532394_-	Multimodular transpeptidase-transglycosylase PBP 1A	NA	NA	NA	NA
ARD90835.1\|532380_533022_-	Recombination protein RecU	NA	NA	NA	NA
ARD90836.1\|533102_533627_+	hypothetical protein	NA	NA	NA	NA
ARD90837.1\|533771_534173_+	Arsenate reductase related protein glutaredoxin family	NA	NA	NA	NA
ARD90838.1\|534393_534675_+	hypothetical protein	NA	NA	NA	NA
ARD90839.1\|534640_535420_+	Myo-inositol-1(or 4)-monophosphatase	NA	NA	NA	NA
ARD90840.1\|535514_536795_+	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	NA	NA	NA	NA
ARD90841.1\|536794_536986_+	hypothetical protein	NA	NA	NA	NA
ARD90842.1\|537064_537622_+\|transposase	IS3/IS911 transposase N-terminal protein	NA	NA	NA	NA
ARD90843.1\|537618_538512_+\|transposase	transposase for insertion sequence IS904H	A0A1B1P773	Bacillus_phage	2.4e-51	42.8
ARD90844.1\|538651_539935_+	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)	NA	NA	NA	NA
ARD90845.1\|546794_548708_+	DNA primase	A0A1S5REW9	Helicobacter_phage	1.7e-43	33.5
ARD90846.1\|548784_550128_+	RNA polymerase sigma 70 subunit RpoD	A0A2I7SAT0	Vibrio_phage	7.2e-36	32.6
ARD90847.1\|551135_552515_+	glycerol-3-phosphatase transporter	NA	NA	NA	NA
ARD90848.1\|553548_554814_+	hypothetical protein	NA	NA	NA	NA
ARD90849.1\|555042_555387_+	hypothetical protein	NA	NA	NA	NA
ARD90850.1\|555432_557679_+\|protease	ATP-dependent Clp protease ATP-binding subunit clpE	K4FB40	Cronobacter_phage	2.1e-125	39.7
ARD90851.1\|557804_558275_-	Transcriptional regulator Rrf2 family	NA	NA	NA	NA
ARD90852.1\|558617_559514_+	glyceraldehyde-3-phosphate dehydrogenase	NA	NA	NA	NA
ARD90853.1\|559737_560373_-\|tRNA	N-formylmethionyl-tRNA deformylase	Q6VSW0	Vibrio_phage	3.8e-11	36.4
ARD90854.1\|560527_560932_+	Bis(5-nucleosyl)-tetraphosphatase (asymmetrical)	NA	NA	NA	NA
ARD90855.1\|560993_563072_+	Excinuclease ABC subunit B	NA	NA	NA	NA
ARD90856.1\|563782_564601_-	Transposase	A0A1B1P773	Bacillus_phage	1.8e-53	43.3
ARD90857.1\|564597_565155_-\|transposase	IS3/IS911 transposase N-terminal protein	NA	NA	NA	NA
ARD90858.1\|566747_567203_-	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	NA	NA	NA	NA
ARD90859.1\|567478_568231_+	Enoyl-[acyl-carrier protein] reductase (NADH)	NA	NA	NA	NA
ARD90860.1\|568416_569379_-	OxaA-like protein precursor	NA	NA	NA	NA
ARD90861.1\|569553_570312_-	alpha-phosphoglucomutase	A0A2P1EM96	Moumouvirus	6.1e-08	25.9
ARD90862.1\|570406_570997_-	membrane protein	NA	NA	NA	NA
ARD90863.1\|571013_571550_-	phosphopantothenoylcysteine decarboxylase	Q9J5A8	Fowlpox_virus	6.8e-22	34.9
ARD90864.1\|571542_572238_-	Phosphopantothenoylcysteine synthetase/decarboxylase	Q9HH70	Methanothermobacter_phage	1.7e-17	31.7
ARD90865.1\|572347_572569_-	4-oxalocrotonate tautomerase	NA	NA	NA	NA
ARD90866.1\|572754_574167_+	Cation transport ATPase	M1HBF8	Paramecium_bursaria_Chlorella_virus	6.0e-25	25.6
ARD90867.1\|574200_574611_+	Cation transport ATPase	NA	NA	NA	NA
ARD90868.1\|574607_574865_-	hypothetical protein	NA	NA	NA	NA
ARD90869.1\|575114_575309_+	Acetyltransferase GNAT family	NA	NA	NA	NA
ARD90870.1\|575329_575590_+	Transposase	A0A1P8CWP5	Bacillus_phage	8.4e-10	37.6
ARD90871.1\|575601_576441_+\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	1.6e-49	41.4

DBSCAN-SWA_5

602210 : 665092

Bacillus_phage(22.22%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD90903.1\|602210_603101_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD90904.1\|603153_603876_+	hypothetical protein	NA	NA	NA	NA
ARD90905.1\|603907_604183_+	membrane protein	NA	NA	NA	NA
ARD90906.1\|604594_605527_+	Hpr(Ser) kinase	NA	NA	NA	NA
ARD90907.1\|605588_606374_+	prolipoprotein diacylglyceryl transferase	NA	NA	NA	NA
ARD90908.1\|606540_606960_+	Methyl-accepting chemotaxis-like domain containing protein	NA	NA	NA	NA
ARD90909.1\|606989_607550_+	hypothetical protein	NA	NA	NA	NA
ARD90910.1\|607683_609102_+	6-phosphogluconate dehydrogenase	E3SJC4	Synechococcus_phage	8.4e-35	33.0
ARD90911.1\|609283_611305_+	Kup system potassium uptake protein	A7K9V6	Acanthocystis_turfacea_chlorella_virus	4.2e-64	33.9
ARD90912.1\|611519_613535_+	Kup system potassium uptake protein	M1IBC2	Acanthocystis_turfacea_Chlorella_virus	3.8e-57	31.6
ARD90913.1\|613587_613758_-	hypothetical protein	NA	NA	NA	NA
ARD90914.1\|613952_614618_+	hypothetical protein	M1Q1P6	Streptococcus_phage	2.3e-19	29.8
ARD90915.1\|614749_615634_+\|tRNA	tRNA delta(2)-isopentenylpyrophosphate transferase	NA	NA	NA	NA
ARD90916.1\|615779_616448_+	hypothetical protein	NA	NA	NA	NA
ARD90917.1\|616612_617515_+\|protease	Membrane protease subunit stomatin/prohibitin family	A0A1V0SL90	Klosneuvirus	1.8e-35	35.2
ARD90918.1\|617763_618429_-	Glycoside hydrolase family 25	A0A1P8BMN5	Lactococcus_phage	3.2e-13	56.9
ARD90919.1\|618887_619235_-	HTH-type transcriptional regulator	A0A182BQC8	Lactococcus_phage	2.0e-43	74.6
ARD90920.1\|619999_620923_+	ribonuclease Z	NA	NA	NA	NA
ARD90921.1\|620915_621617_+	Short-chain dehydrogenase	NA	NA	NA	NA
ARD90922.1\|621789_624018_+	single strand DNA-specific exonuclease	A7KV88	Bacillus_phage	6.7e-79	30.9
ARD90923.1\|624141_624654_+	Adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.3e-32	44.0
ARD90924.1\|624869_625433_+	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
ARD90925.1\|625571_627209_+	aminodeoxychorismate lyase	NA	NA	NA	NA
ARD90926.1\|627269_627740_+	transcription elongation factor GreA	NA	NA	NA	NA
ARD90927.1\|627934_628306_+	Transposase	NA	NA	NA	NA
ARD90928.1\|628302_629121_+	Transposase	A0A1B1P773	Bacillus_phage	3.0e-53	43.0
ARD90929.1\|629175_630015_-	Transposase	U5P429	Shigella_phage	1.6e-46	41.0
ARD90930.1\|630032_630323_-	Transposase	NA	NA	NA	NA
ARD90931.1\|630570_631026_+	Transcriptional repressor of class III stress protein CtsR	NA	NA	NA	NA
ARD90932.1\|631015_633466_+\|protease	ATP-dependent Clp protease ATP-binding subunit	A0A223W0B1	Agrobacterium_phage	2.2e-123	34.0
ARD90933.1\|633600_634158_+	sigma 54 modulation protein	NA	NA	NA	NA
ARD90934.1\|634345_635647_+	enolase	A0A1X9I5Z8	Streptococcus_phage	4.0e-217	87.6
ARD90935.1\|635750_636422_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	4.2e-29	36.8
ARD90936.1\|636423_637497_-	ABC transporter permease	NA	NA	NA	NA
ARD90937.1\|637508_638078_-	transcriptional regulator	NA	NA	NA	NA
ARD90938.1\|638264_639788_-	long-chain acyl-CoA synthetase	NA	NA	NA	NA
ARD90939.1\|639981_640899_+	Mg2 and Co2 transporter CorA family	NA	NA	NA	NA
ARD90940.1\|641158_643522_+	formate acetyltransferase	A0A2P0VNR5	Tetraselmis_virus	3.6e-107	31.8
ARD90941.1\|643650_644310_+	dephospho-CoA kinase	NA	NA	NA	NA
ARD90942.1\|644402_645530_+	multidrug resistance efflux pump	NA	NA	NA	NA
ARD90943.1\|645526_645673_+	LSU ribosomal protein L33P	NA	NA	NA	NA
ARD90944.1\|646050_647313_+	cell division-specific peptidoglycan biosynthesis regulator FtsW	NA	NA	NA	NA
ARD90945.1\|647417_650831_+	pyruvate carboxylase	NA	NA	NA	NA
ARD90946.1\|652278_654825_+	aconitate hydratase	NA	NA	NA	NA
ARD90947.1\|654844_656083_+	Isocitrate dehydrogenase [NADP]	NA	NA	NA	NA
ARD90948.1\|656122_656722_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	7.1e-52	52.6
ARD90949.1\|656916_657447_+	hypothetical protein	NA	NA	NA	NA
ARD90950.1\|657616_658015_+	Arsenate reductase related protein glutaredoxin family	NA	NA	NA	NA
ARD90951.1\|658165_658300_-	secreted protein	NA	NA	NA	NA
ARD90952.1\|658396_659560_-	ABC transporter, permease protein	NA	NA	NA	NA
ARD90953.1\|662625_662859_+\|transposase	IS981 transposase A	A0A1P8CWP5	Bacillus_phage	2.1e-07	35.1
ARD90954.1\|662896_663736_+	Transposase	A0A1P8CWQ3	Bacillus_phage	9.3e-50	41.4
ARD90955.1\|663837_664095_+	hypothetical protein	NA	NA	NA	NA
ARD90956.1\|664201_665092_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA

DBSCAN-SWA_6

857598 : 970889

107

Bacillus_phage(24.0%)

integrase,transposase

attL 909987:910004|attR 959966:959983

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD91127.1\|857598_858489_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91128.1\|859075_859336_+	Transposase	A0A1P8CWP5	Bacillus_phage	6.5e-10	40.0
ARD91129.1\|859586_860177_+\|transposase	transposase for insertion sequence element IS981O	Q6J1X2	Lactobacillus_phage	1.2e-35	42.6
ARD91130.1\|860228_861044_-	glycosyltransferase	NA	NA	NA	NA
ARD91131.1\|861358_862777_+	dipeptidase PepV	NA	NA	NA	NA
ARD91132.1\|862905_863265_+	Phosphopantetheinyl transferase (holo-ACP synthase)	NA	NA	NA	NA
ARD91133.1\|863308_864412_+	alanine racemase	A0A0P0YM39	Yellowstone_lake_mimivirus	6.3e-30	28.1
ARD91134.1\|864572_865001_+	Arsenate reductase related protein glutaredoxin family	NA	NA	NA	NA
ARD91135.1\|865139_866447_+	glutathione reductase	NA	NA	NA	NA
ARD91136.1\|866575_867493_+	ABC-type proline/glycine betaine transport system ATPase component	G3M9Y6	Bacillus_virus	9.0e-22	30.1
ARD91137.1\|867489_868992_+	Glycine betaine ABC transporter permease and substrate-binding protein	NA	NA	NA	NA
ARD91138.1\|869253_871788_+	Hypothetical protein	NA	NA	NA	NA
ARD91139.1\|871774_872314_+	hypothetical protein	NA	NA	NA	NA
ARD91140.1\|872323_872701_+	hypothetical protein	NA	NA	NA	NA
ARD91141.1\|872716_873295_+	hypothetical protein	NA	NA	NA	NA
ARD91142.1\|873276_874167_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91143.1\|876556_877444_+	5,10-methylenetetrahydrofolate dehydrogenase (NADP+)	A0A249XZQ2	Enterococcus_phage	2.1e-39	39.0
ARD91144.1\|877614_878868_+	Exodeoxyribonuclease VII large subunit	A0A2H4UVM9	Bodo_saltans_virus	1.2e-45	32.3
ARD91145.1\|878870_879110_+	Exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
ARD91146.1\|879336_880227_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91147.1\|880285_881431_+	Glycerate kinase	W6LM47	Streptococcus_phage	4.5e-47	38.8
ARD91148.1\|881655_882513_+	Dimethylallyltransferase/geranyltranstransferase	NA	NA	NA	NA
ARD91149.1\|882513_883014_+	acetyltransferase	NA	NA	NA	NA
ARD91150.1\|883089_883896_+	rRNA methylase	NA	NA	NA	NA
ARD91151.1\|883892_884339_+	transcriptional regulator ArgR family	NA	NA	NA	NA
ARD91152.1\|884518_886186_+	DNA repair protein recN	NA	NA	NA	NA
ARD91153.1\|886885_887452_+	hypothetical protein	NA	NA	NA	NA
ARD91154.1\|887546_888068_+	hypothetical protein	NA	NA	NA	NA
ARD91155.1\|889246_890200_+	S-adenosyl-methyltransferase MraW	NA	NA	NA	NA
ARD91156.1\|890355_890736_+	Cell division protein FtsL DivIC superfamily	NA	NA	NA	NA
ARD91157.1\|890732_893030_+	Cell division specific DD-transpeptidase FtsI	NA	NA	NA	NA
ARD91158.1\|893104_894094_+	phospho-N-acetylmuramoyl-pentapeptide- transferase	NA	NA	NA	NA
ARD91159.1\|894292_894577_+	hypothetical protein	NA	NA	NA	NA
ARD91160.1\|896352_897015_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.4e-21	32.7
ARD91161.1\|897374_898262_+	malolactic fermentation system transcription activator	NA	NA	NA	NA
ARD91162.1\|898520_899411_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91163.1\|899497_900172_+	RelA / SpoT (ppGpp synthetase/hydrolase) catalytic domain	NA	NA	NA	NA
ARD91164.1\|900331_900676_+	LSU ribosomal protein L19P	NA	NA	NA	NA
ARD91165.1\|901605_902067_-	Acetyltransferase GNAT family	NA	NA	NA	NA
ARD91166.1\|902321_902621_+	hypothetical protein	NA	NA	NA	NA
ARD91167.1\|902824_904153_+	Glycosyltransferase family 2 cellulose synthase (CESA) superfamily	NA	NA	NA	NA
ARD91168.1\|904383_904941_+	hypothetical protein	NA	NA	NA	NA
ARD91169.1\|905003_905249_-	hypothetical protein	NA	NA	NA	NA
ARD91170.1\|905521_906247_+	Nicotinamide mononucleotide transporter	A0A2P0ZKW0	Lactobacillus_phage	1.1e-14	28.7
ARD91171.1\|906389_906545_-	hypothetical protein	NA	NA	NA	NA
ARD91172.1\|906799_907225_+	universal stress protein A	NA	NA	NA	NA
ARD91173.1\|907392_907755_+	HU-like DNA-binding protein	NA	NA	NA	NA
ARD91174.1\|907816_908350_-	transcriptional regulator TetR family	NA	NA	NA	NA
ARD91175.1\|909021_909912_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
909987:910004	attL	NA	NA	NA	NA
ARD91176.1\|912106_912439_+	metal-sulfur cluster biosynthetic enzyme	NA	NA	NA	NA
ARD91177.1\|912574_913549_+\|integrase	integrase/recombinase	A0A142F1N9	Bacillus_phage	1.9e-30	28.3
ARD91178.1\|913736_914357_-	hypothetical protein	NA	NA	NA	NA
ARD91179.1\|914433_914694_+	Transposase	A0A1P8CWP5	Bacillus_phage	8.4e-10	37.6
ARD91180.1\|914705_915545_+\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	6.0e-49	41.4
ARD91181.1\|915892_916189_+	hypothetical protein	NA	NA	NA	NA
ARD91182.1\|916523_917153_+	secreted membrane protein	NA	NA	NA	NA
ARD91183.1\|917149_918148_+	Two-component sensor protein kinase	NA	NA	NA	NA
ARD91184.1\|918175_918805_+	DNA-binding response regulator (Rec-wHTH domains)	NA	NA	NA	NA
ARD91185.1\|918875_919682_+	Hydrolase HAD superfamily Cof subfamily	NA	NA	NA	NA
ARD91186.1\|919781_920372_+	peptidyl-prolyl cis-trans isomerase	A0A1V0S9I2	Catovirus	3.2e-28	45.5
ARD91187.1\|920373_920805_+	RNA binding protein (contains ribosomal protein S1 domain)	NA	NA	NA	NA
ARD91188.1\|920801_921407_+	hypothetical protein	M1Q152	Streptococcus_phage	1.0e-29	36.9
ARD91189.1\|921618_922863_+	rod shape-determining protein RodA	NA	NA	NA	NA
ARD91190.1\|924194_924956_+	Acetoin dehydrogenase	NA	NA	NA	NA
ARD91191.1\|925228_925390_+	hypothetical protein	NA	NA	NA	NA
ARD91192.1\|925500_927051_+	ABC transporter ATP-binding protein	Q6DMX7	Streptococcus_phage	6.0e-26	23.6
ARD91193.1\|927465_929088_+	NAD-dependent malic enzyme	NA	NA	NA	NA
ARD91194.1\|929102_930380_+	Na+/malate symporter	NA	NA	NA	NA
ARD91195.1\|930564_931464_+	permease of the drug/metabolite transporter (DMT) superfamily	NA	NA	NA	NA
ARD91196.1\|931586_932351_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	4.5e-27	28.4
ARD91197.1\|932331_933912_+	ABC transporter permease protein	NA	NA	NA	NA
ARD91198.1\|934997_935645_+	P-Ser-HPr phosphatase	NA	NA	NA	NA
ARD91199.1\|935798_937754_+	DNA gyrase subunit B	G3M9Z3	Bacillus_virus	2.9e-142	44.7
ARD91200.1\|937850_938036_+	hypothetical protein	NA	NA	NA	NA
ARD91201.1\|938915_939425_+	SAM-dependent methyltransferase	A0A1X9I6N4	Streptococcus_phage	2.6e-47	55.4
ARD91202.1\|939597_940239_+	secreted protein	NA	NA	NA	NA
ARD91203.1\|940396_940861_+	MarR family transcriptional regulator	NA	NA	NA	NA
ARD91204.1\|940919_942398_+	Multidrug resistance protein B MF superfamily	NA	NA	NA	NA
ARD91205.1\|942397_943117_+	hypothetical protein	NA	NA	NA	NA
ARD91206.1\|943430_944285_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91207.1\|944448_945261_+	Exopolysaccharide biosynthesis protein	NA	NA	NA	NA
ARD91208.1\|945293_946133_-\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	2.7e-49	41.8
ARD91209.1\|946144_946405_-\|transposase	IS981 transposase A	A0A1P8CWP5	Bacillus_phage	6.5e-10	40.0
ARD91210.1\|946507_949519_+	glycosyltransferase	NA	NA	NA	NA
ARD91211.1\|949619_950510_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91212.1\|950534_950759_+	hypothetical protein	NA	NA	NA	NA
ARD91213.1\|950748_951864_+	CDP-glycerol/poly(glycerophosphate) glycerophosphotransferase	NA	NA	NA	NA
ARD91214.1\|951963_952794_+	Transcriptional regulator	NA	NA	NA	NA
ARD91215.1\|952980_954216_+	Phosphopentomutase	NA	NA	NA	NA
ARD91216.1\|954306_954543_+	hypothetical protein	NA	NA	NA	NA
ARD91217.1\|954613_955318_+	purine-nucleoside phosphorylase	NA	NA	NA	NA
ARD91218.1\|955753_956041_-	hypothetical protein	A0A1B1IMF9	Lactococcus_phage	2.5e-07	87.9
ARD91219.1\|956573_957020_+	hypothetical protein	NA	NA	NA	NA
ARD91220.1\|957103_957430_+	hypothetical protein	NA	NA	NA	NA
ARD91221.1\|957590_959258_+	Formate-tetrahydrofolate ligase	NA	NA	NA	NA
ARD91222.1\|959366_959960_+	Cell wall-associated hydrolase	A0A1V0DZX6	Clostridioides_phage	2.4e-15	43.5
ARD91223.1\|959985_960876_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
959966:959983	attR	NA	NA	NA	NA
ARD91224.1\|961111_961960_+	amino acid ABC transporter substrate binding protein	NA	NA	NA	NA
ARD91225.1\|962228_963116_+	amino acid ABC transporter membrane protein PAAT family	NA	NA	NA	NA
ARD91226.1\|963127_963880_+	amino acid ABC transporter ATP-binding protein PAAT family	G9BWD6	Planktothrix_phage	1.8e-28	39.2
ARD91227.1\|963881_964109_+	hypothetical protein	NA	NA	NA	NA
ARD91228.1\|964306_965233_+	Thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.0e-85	51.1
ARD91229.1\|965373_965622_+	Preprotein translocase subunit SecG	NA	NA	NA	NA
ARD91230.1\|965863_968317_+	Exoribonuclease R VacB family	Q0GXV6	Lactococcus_phage	1.3e-104	44.2
ARD91231.1\|968335_968923_+	Isochorismatase family protein	NA	NA	NA	NA
ARD91232.1\|969000_970017_+	endonuclease/exonuclease/phosphatase family protein	NA	NA	NA	NA
ARD91233.1\|969998_970889_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA

DBSCAN-SWA_7

1011648 : 1035346

Bacillus_phage(18.75%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD91274.1\|1011648_1012341_+	cell division ATP-binding protein	G9BWD6	Planktothrix_phage	4.2e-32	35.3
ARD91275.1\|1012333_1013269_+	cell division protein ftsX-like protein	NA	NA	NA	NA
ARD91276.1\|1013378_1014356_-	ribonucleoside-diphosphate reductase class Ib beta subunit	A0A096XT60	Enterococcus_phage	6.0e-117	65.7
ARD91277.1\|1014739_1016908_-	ribonucleoside-diphosphate reductase class Ib alpha subunit	A8E2R1	Enterococcus_phage	3.3e-256	60.7
ARD91278.1\|1017044_1017467_-	ribonucleotide reductase stimulatory protein	A0A142F1R4	Bacillus_phage	1.7e-12	36.4
ARD91279.1\|1017468_1017687_-	ribonucleoside-diphosphate reductase class Ib glutaredoxin subunit	C3U2K9	Lactococcus_phage	5.8e-12	47.6
ARD91280.1\|1017860_1018502_-	acyl-phosphate glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
ARD91281.1\|1018780_1020715_+	DNA topoisomerase IV subunit B	G3M9Z3	Bacillus_virus	4.1e-125	42.9
ARD91282.1\|1020821_1021358_+	isochorismatase	NA	NA	NA	NA
ARD91283.1\|1021350_1022184_+	DNA polymerase III epsilon chain	A0A0K2SUJ2	Clostridium_phage	1.5e-20	38.7
ARD91284.1\|1022180_1022561_+	Acetyltransferase GNAT family	NA	NA	NA	NA
ARD91285.1\|1022781_1025256_+	DNA topoisomerase IV subunit A	G3M9Z5	Bacillus_virus	1.0e-96	31.9
ARD91286.1\|1026073_1026754_+	Transposase	A0A1X9I6C6	Streptococcus_phage	8.5e-110	84.5
ARD91287.1\|1027494_1028583_+	riboflavin biosynthesis protein RibD	A0A1V0SE20	Indivirus	8.4e-51	37.8
ARD91288.1\|1028582_1029230_+	Riboflavin synthase alpha chain	A0A2H4PQS5	Staphylococcus_phage	5.5e-42	44.7
ARD91289.1\|1029241_1030438_+	GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	7.4e-109	50.3
ARD91290.1\|1030464_1030929_+	67-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.4e-39	55.3
ARD91291.1\|1031110_1031371_+	Transposase	A0A1P8CWP5	Bacillus_phage	1.1e-09	36.5
ARD91292.1\|1031382_1032222_+\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	6.0e-49	41.1
ARD91293.1\|1032254_1033157_-	transcription regulator	NA	NA	NA	NA
ARD91294.1\|1033255_1033636_+	hypothetical protein	NA	NA	NA	NA
ARD91295.1\|1033925_1034378_+	signal peptidase II Aspartic peptidase MEROPS family A08	NA	NA	NA	NA
ARD91296.1\|1034440_1035346_+	ribosomal large subunit pseudouridine synthase D	A0A2H4UV25	Bodo_saltans_virus	3.5e-10	27.8

DBSCAN-SWA_8

1150476 : 1193875

Bacillus_phage(25.0%)

tRNA,protease,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD91405.1\|1150476_1151712_+\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	2.4e-134	58.6
ARD91406.1\|1151708_1152296_+	ribosome biogenesis GTP-binding protein YsxC	NA	NA	NA	NA
ARD91407.1\|1152349_1152700_+	Dihydroneopterin aldolase	NA	NA	NA	NA
ARD91408.1\|1152779_1153829_+	GTP cyclohydrolase I	A0A088F7Y4	Vibrio_phage	8.7e-37	45.1
ARD91409.1\|1153825_1154899_+	dihydropteroate synthase	NA	NA	NA	NA
ARD91410.1\|1154901_1155402_+	Dihydroneopterin triphosphate pyrophosphohydrolase	NA	NA	NA	NA
ARD91411.1\|1155417_1156701_+	Folylpolyglutamate synthase / Dihydrofolate synthase	NA	NA	NA	NA
ARD91412.1\|1156829_1157468_+	Deoxynucleoside kinase	Q5ULP7	Lactobacillus_virus	5.4e-50	47.9
ARD91413.1\|1157647_1158934_+	homoserine dehydrogenase	NA	NA	NA	NA
ARD91414.1\|1158938_1159829_+	homoserine kinase	NA	NA	NA	NA
ARD91415.1\|1160082_1160682_+	hypothetical protein	NA	NA	NA	NA
ARD91416.1\|1160724_1161624_+	UDP-N-acetylenolpyruvoylglucosamine reductase	NA	NA	NA	NA
ARD91417.1\|1162083_1163364_+	spermidine/putrescine ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	6.0e-32	38.4
ARD91418.1\|1163360_1164149_+	spermidine/putrescine ABC transporter permease protein	NA	NA	NA	NA
ARD91419.1\|1164150_1164951_+	spermidine/putrescine ABC transporter permease protein	NA	NA	NA	NA
ARD91420.1\|1164998_1166066_+	spermidine/putrescine ABC transporter substrate-binding protein	NA	NA	NA	NA
ARD91421.1\|1166663_1167275_-	transcriptional regulator AraC family	NA	NA	NA	NA
ARD91422.1\|1167274_1168468_-	hypothetical protein	NA	NA	NA	NA
ARD91423.1\|1168764_1169946_+	hypothetical protein	NA	NA	NA	NA
ARD91424.1\|1169978_1171640_+	Beta-14-xylosidase	NA	NA	NA	NA
ARD91425.1\|1172241_1172475_+	hypothetical protein	NA	NA	NA	NA
ARD91426.1\|1172581_1172926_+	Transcriptional regulator Xre family	NA	NA	NA	NA
ARD91427.1\|1173154_1173913_+	surface protein	NA	NA	NA	NA
ARD91428.1\|1174002_1174893_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91429.1\|1175105_1175420_+	transcriptional regulator	NA	NA	NA	NA
ARD91430.1\|1176177_1176594_+	Arsenate reductase family protein	NA	NA	NA	NA
ARD91431.1\|1176958_1177369_-	transcriptional regulator	NA	NA	NA	NA
ARD91432.1\|1177540_1178398_+	Aldo/keto reductase	A0A1V0SKP9	Klosneuvirus	2.4e-29	30.4
ARD91433.1\|1178435_1179326_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91434.1\|1179743_1180583_-\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	6.0e-49	41.1
ARD91435.1\|1180594_1180855_-\|transposase	IS981 transposase A	A0A1P8CWP5	Bacillus_phage	2.5e-09	36.5
ARD91436.1\|1181198_1181903_-	N-acetylmannosamine-6-phosphate 2-epimerase	NA	NA	NA	NA
ARD91437.1\|1182924_1184295_+\|tRNA	tRNA (uracil-5-)-methyltransferase related enzyme	E4ZFI6	Streptococcus_phage	3.8e-141	56.0
ARD91438.1\|1184339_1185947_+	NAD(FAD)-utilizing dehydrogenase	NA	NA	NA	NA
ARD91439.1\|1185948_1186569_+	SAM-dependent methyltransferase	NA	NA	NA	NA
ARD91440.1\|1186634_1187807_+	hypothetical protein	NA	NA	NA	NA
ARD91441.1\|1187834_1189091_+	TPR repeat-containing protein Tetratricopeptide repeat family	NA	NA	NA	NA
ARD91442.1\|1189245_1190910_+	acetolactate synthase	NA	NA	NA	NA
ARD91443.1\|1191016_1192162_-	arabinose efflux permease	NA	NA	NA	NA
ARD91444.1\|1192269_1192668_+	transcriptional regulator	NA	NA	NA	NA
ARD91445.1\|1192984_1193875_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA

DBSCAN-SWA_9

1326217 : 1390295

Bacillus_phage(44.44%)

transposase,lysis

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD91548.1\|1326217_1327108_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91549.1\|1327327_1327513_-	hypothetical protein	NA	NA	NA	NA
ARD91550.1\|1327512_1330125_-	putative extracellular LPXTG-anchored protein	R9R2F6	Lactococcus_phage	3.4e-05	45.7
ARD91551.1\|1330467_1330911_-	hypothetical protein	NA	NA	NA	NA
ARD91552.1\|1331215_1332838_+	Fibronectin-binding protein	Q84500	Paramecium_bursaria_Chlorella_virus	5.5e-06	32.1
ARD91553.1\|1332879_1333695_+	23S rRNA m(1)G 745 methyltransferase	NA	NA	NA	NA
ARD91554.1\|1333876_1335397_+	purine/cytidine ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.4e-19	32.1
ARD91555.1\|1335389_1336484_+	purine/cytidine ABC transporter permease protein	NA	NA	NA	NA
ARD91556.1\|1336480_1337434_+	nucleoside ABC transporter membrane protein	NA	NA	NA	NA
ARD91557.1\|1337550_1338528_-	L-lactate dehydrogenase	NA	NA	NA	NA
ARD91558.1\|1338645_1340154_-	pyruvate kinase	NA	NA	NA	NA
ARD91559.1\|1340241_1341264_-	6-phosphofructokinase	NA	NA	NA	NA
ARD91560.1\|1341651_1342800_-	N-acetylglucosamine 6-phosphate deacetylase	NA	NA	NA	NA
ARD91561.1\|1342970_1344149_-	toxic anion resistance protein	A0A291I9K4	Lactobacillus_phage	1.5e-37	28.8
ARD91562.1\|1344290_1344917_-\|lysis	5-bromo-4-chloroindolyl phosphate hydrolysis protein	NA	NA	NA	NA
ARD91563.1\|1345107_1346136_+	Glycerol-3-phosphate dehydrogenase [NAD(P) ]	NA	NA	NA	NA
ARD91564.1\|1346177_1347119_+	UDP--glucose-1-phosphate uridylyltransferase	A0A127AW70	Bacillus_phage	2.8e-79	52.2
ARD91565.1\|1347189_1347597_+	hypothetical protein	NA	NA	NA	NA
ARD91566.1\|1347593_1348124_+	heptaprenyl diphosphate synthase component I	NA	NA	NA	NA
ARD91567.1\|1348114_1349074_+	heptaprenyl diphosphate synthase component II	NA	NA	NA	NA
ARD91568.1\|1349070_1349787_+	16S rRNA methyltransferase GidB	NA	NA	NA	NA
ARD91569.1\|1349795_1350254_-	hypothetical protein	NA	NA	NA	NA
ARD91570.1\|1350255_1350969_-	orotidine-5-phosphate decarboxylase	NA	NA	NA	NA
ARD91571.1\|1351098_1352034_-	dihydroorotate dehydrogenase 1B	NA	NA	NA	NA
ARD91572.1\|1352264_1353053_-	Dihydroorotate dehydrogenase electron transfer subunit	NA	NA	NA	NA
ARD91573.1\|1353302_1354667_-	Multidrug resistance protein B MF superfamily	NA	NA	NA	NA
ARD91574.1\|1354864_1355581_-	trehalose operon transcriptional repressor	NA	NA	NA	NA
ARD91575.1\|1355651_1357079_-	Beta-glucosidase/6-phospho-beta- glucosidase/beta-galactosidase	NA	NA	NA	NA
ARD91576.1\|1357088_1357829_-	3-ketoacyl-(acyl-carrier-protein) reductase	NA	NA	NA	NA
ARD91577.1\|1357829_1358375_-	hypothetical protein	NA	NA	NA	NA
ARD91578.1\|1358371_1359208_-	sugar transport system permease protein	NA	NA	NA	NA
ARD91579.1\|1359207_1360164_-	carbohydrate ABC transporter membrane protein 1 CUT1 family	NA	NA	NA	NA
ARD91580.1\|1360198_1361518_-	sugar ABC transporter substrate-binding protein	NA	NA	NA	NA
ARD91581.1\|1363746_1364976_+	hypothetical protein	NA	NA	NA	NA
ARD91582.1\|1365189_1366341_+	ATP/GTP binding protein	NA	NA	NA	NA
ARD91583.1\|1366337_1367123_+	Beta-propeller domains of methanol dehydrogenase type	NA	NA	NA	NA
ARD91584.1\|1367157_1367691_-	ribosomal large subunit pseudouridine synthase E	NA	NA	NA	NA
ARD91585.1\|1367990_1369508_+	glycerol kinase	NA	NA	NA	NA
ARD91586.1\|1369560_1371138_+	Alpha-glycerophosphate oxidase	NA	NA	NA	NA
ARD91587.1\|1371156_1371750_+	glycerol uptake facilitator	NA	NA	NA	NA
ARD91588.1\|1371669_1371939_-	cell surface protein	NA	NA	NA	NA
ARD91589.1\|1372017_1372830_-	hypothetical protein	NA	NA	NA	NA
ARD91590.1\|1372810_1373146_-	hypothetical protein	NA	NA	NA	NA
ARD91591.1\|1373461_1374301_-\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	1.2e-49	41.4
ARD91592.1\|1374312_1374573_-\|transposase	IS981 transposase A	A0A1P8CWP5	Bacillus_phage	1.9e-09	37.6
ARD91593.1\|1374593_1375253_-	secreted protein	NA	NA	NA	NA
ARD91594.1\|1375420_1377331_-	hypothetical protein	NA	NA	NA	NA
ARD91595.1\|1377406_1377988_-	hypothetical protein	NA	NA	NA	NA
ARD91596.1\|1378186_1381381_-	Carbamoyl-phosphate synthase large chain	NA	NA	NA	NA
ARD91597.1\|1381730_1382204_-	Glutathione peroxidase	NA	NA	NA	NA
ARD91598.1\|1383102_1385736_-	Calcium-transporting ATPase	M1HX51	Paramecium_bursaria_Chlorella_virus	4.5e-90	30.8
ARD91599.1\|1385993_1386719_-	hypothetical protein	NA	NA	NA	NA
ARD91600.1\|1386938_1387370_-	hypothetical protein	NA	NA	NA	NA
ARD91601.1\|1387426_1388266_-\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	1.6e-49	41.4
ARD91602.1\|1388277_1388430_-	Transposase	NA	NA	NA	NA
ARD91603.1\|1388686_1389241_+	hypothetical protein	NA	NA	NA	NA
ARD91604.1\|1389404_1390295_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA

DBSCAN-SWA_10

1408888 : 1471080

Acinetobacter_phage(17.65%)

holin,transposase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD91626.1\|1408888_1410112_-\|holin	Glycine betaine/carnitine/choline ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.7e-28	36.9
ARD91627.1\|1410323_1410944_-	transcriptional regulator GntR family	NA	NA	NA	NA
ARD91628.1\|1411109_1412612_-	Beta-glucosidase/ 6-phospho-beta-glucosidase	NA	NA	NA	NA
ARD91629.1\|1412633_1413314_-	Transposase	A0A1X9I6C6	Streptococcus_phage	8.5e-110	84.5
ARD91630.1\|1413350_1413875_-	transcriptional antiterminator BglG family	NA	NA	NA	NA
ARD91631.1\|1414050_1414812_-	tryptophan synthase subunit alpha	NA	NA	NA	NA
ARD91632.1\|1414811_1416017_-	Tryptophan synthase beta chain	NA	NA	NA	NA
ARD91633.1\|1416115_1416634_-	Acetyltransferase including N-acetylase of ribosomal protein	NA	NA	NA	NA
ARD91634.1\|1416623_1417682_-	N-(5-phosphoribosyl)anthranilate isomerase	NA	NA	NA	NA
ARD91635.1\|1417671_1418466_-	indole-3-glycerol phosphate synthase	A0A0P0IR83	Acinetobacter_phage	1.7e-29	35.5
ARD91636.1\|1419129_1419483_-	hypothetical protein	NA	NA	NA	NA
ARD91637.1\|1419437_1419932_-	hypothetical protein	NA	NA	NA	NA
ARD91638.1\|1420129_1421137_-	Anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	6.6e-50	35.9
ARD91639.1\|1421141_1421723_-	anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	5.5e-33	45.1
ARD91640.1\|1421774_1423145_-	anthranilate synthase component I	NA	NA	NA	NA
ARD91641.1\|1423598_1423958_-	membrane protein	NA	NA	NA	NA
ARD91642.1\|1423972_1424611_-	Nitroreductase/Transcriptional regulator MarR family	NA	NA	NA	NA
ARD91643.1\|1424622_1425042_-	MarR family transcriptional regulator	NA	NA	NA	NA
ARD91644.1\|1425151_1425895_-	Methylase for ubiquinone/menaquinone biosynthesis	NA	NA	NA	NA
ARD91645.1\|1425970_1426651_-	hypothetical protein	NA	NA	NA	NA
ARD91646.1\|1426650_1427340_-	hypothetical protein	NA	NA	NA	NA
ARD91647.1\|1427466_1427853_+	ferric uptake regulation protein	NA	NA	NA	NA
ARD91648.1\|1428033_1428924_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91649.1\|1429020_1429374_-	transcriptional regulator	NA	NA	NA	NA
ARD91650.1\|1429531_1430263_+	Short-chain alcohol dehydrogenase	A0A2P0VP75	Tetraselmis_virus	5.5e-06	28.8
ARD91651.1\|1430372_1432172_-	1-deoxy-D-xylulose-5-phosphate synthase	NA	NA	NA	NA
ARD91652.1\|1432432_1432852_-	transcriptional regulator MarR family	NA	NA	NA	NA
ARD91653.1\|1433027_1433933_+	cationic transporter	NA	NA	NA	NA
ARD91654.1\|1434031_1435411_+	Na+-driven multidrug efflux pump MatE family	NA	NA	NA	NA
ARD91655.1\|1435454_1437482_-	hypothetical protein	NA	NA	NA	NA
ARD91656.1\|1437890_1438589_-	secreted protein	NA	NA	NA	NA
ARD91657.1\|1438708_1440343_-	Oligosaccharide ABC transporter oligosaccharide-binding protein	NA	NA	NA	NA
ARD91658.1\|1440414_1441278_-	Oligosaccharider ABC transporter permease protein	NA	NA	NA	NA
ARD91659.1\|1441288_1442179_-	Oligosaccharide ABC transporter permease protein	NA	NA	NA	NA
ARD91660.1\|1442511_1444053_-	GMP synthase (glutamine-hydrolyzing)	A0A1V0SH76	Hokovirus	7.0e-19	30.3
ARD91661.1\|1444262_1445138_-	fructokinase	NA	NA	NA	NA
ARD91662.1\|1445268_1446159_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD91663.1\|1447173_1448499_-	Xylose isomerase	NA	NA	NA	NA
ARD91664.1\|1448609_1449542_+	xylose operon regulator	NA	NA	NA	NA
ARD91665.1\|1449697_1450804_-	phosphoribosylaminoimidazole carboxylase ATPase subunit	NA	NA	NA	NA
ARD91666.1\|1450859_1451345_-	phosphoribosylaminoimidazole carboxylase catalytic subunit	A0A2P0VNU7	Tetraselmis_virus	7.3e-23	43.0
ARD91667.1\|1451341_1452070_-	hydrolase	NA	NA	NA	NA
ARD91668.1\|1452141_1453383_-	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
ARD91669.1\|1453776_1454403_+	TetR family transcriptional regulator	NA	NA	NA	NA
ARD91670.1\|1456758_1458315_-	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	3.6e-71	46.2
ARD91671.1\|1458491_1459034_-	Hypoxanthine-guanine phosphoribosyltransferase	A0A218MMB5	uncultured_virus	6.1e-10	30.6
ARD91672.1\|1460229_1460760_+	Transcriptional regulator TetR family	NA	NA	NA	NA
ARD91673.1\|1460811_1461366_-	ABC-type multidrug transport system ATPase and permease component	F2Y1V6	Organic_Lake_phycodnavirus	1.5e-11	34.3
ARD91674.1\|1461328_1462402_-	Multidrug resistance ABC transporter ATP-binding and permease protein	NA	NA	NA	NA
ARD91675.1\|1462592_1463141_-	formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.5e-19	32.0
ARD91676.1\|1463169_1464186_-	Phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	2.4e-60	41.5
ARD91677.1\|1464375_1466979_-\|protease	ATP-dependent Clp protease chaperonin ATPase ClpB	K4FB40	Cronobacter_phage	1.4e-123	32.7
ARD91678.1\|1467166_1467925_-	secreted protein	A0A1P8BMN5	Lactococcus_phage	2.0e-11	47.6
ARD91679.1\|1469086_1470310_+\|transposase	transposase for insertion sequence element IS712H	A0A059NT83	Lactococcus_phage	6.4e-233	99.8
ARD91680.1\|1470321_1471080_+\|transposase	transposase helper protein for IS712H	A0A059NT77	Lactococcus_phage	5.3e-137	100.0

DBSCAN-SWA_11

1846966 : 1857263

Lactococcus_phage(62.5%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD92038.1\|1846966_1847905_-	Glycosyl transferase family 2	V9QJB1	Oenococcus_phage	1.0e-81	50.6
ARD92039.1\|1847822_1849352_-	hypothetical protein	NA	NA	NA	NA
ARD92040.1\|1849513_1850353_-\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	3.5e-49	41.1
ARD92041.1\|1850364_1850625_-	Transposase	A0A1P8CWP5	Bacillus_phage	8.4e-10	37.6
ARD92042.1\|1850736_1851063_-	hypothetical protein	NA	NA	NA	NA
ARD92043.1\|1851134_1851554_-	deoxyuridine 5-triphosphate nucleotidohydrolase	A5GYP0	Lactococcus_phage	9.0e-70	95.7
ARD92044.1\|1851785_1852544_-\|transposase	transposase helper protein for IS712H	A0A059NT77	Lactococcus_phage	5.3e-137	100.0
ARD92045.1\|1852555_1853779_-\|transposase	transposase for insertion sequence element IS712H	A0A059NT83	Lactococcus_phage	6.4e-233	99.8
ARD92046.1\|1853854_1854379_-	hypothetical protein	NA	NA	NA	NA
ARD92047.1\|1854641_1855226_+	cI-like repressor	A5GYQ3	Lactococcus_phage	4.0e-60	72.2
ARD92048.1\|1855231_1855666_+	hypothetical protein	NA	NA	NA	NA
ARD92049.1\|1855679_1856015_+	hypothetical protein	NA	NA	NA	NA
ARD92050.1\|1856081_1857263_+	Integrase	Q9AZK8	Lactococcus_phage	2.0e-90	47.5

DBSCAN-SWA_12

1948965 : 1998116

Bacillus_phage(36.36%)

tRNA,transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ARD92132.1\|1948965_1949856_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD92133.1\|1951108_1952248_-	transcription regulator/NMN adenylyltransferase/ribosylnicotinamide kinase	A0A2K9VDE3	Lactobacillus_phage	1.5e-119	55.4
ARD92134.1\|1952234_1953212_-	D-Isomer specific 2-hydroxyacid dehydrogenase NAD-dependent	NA	NA	NA	NA
ARD92135.1\|1953409_1954702_-	Peptidase U32 family	Q6DW11	Phage_TP	1.0e-39	33.7
ARD92136.1\|1954986_1955958_-	Peptidase U32 family	NA	NA	NA	NA
ARD92137.1\|1956129_1956411_+	hypothetical protein	NA	NA	NA	NA
ARD92138.1\|1956440_1957262_-	23S rRNA m(1)G-748 methyltransferase	NA	NA	NA	NA
ARD92139.1\|1957380_1958007_+	Copper homeostasis protein	NA	NA	NA	NA
ARD92140.1\|1958039_1959059_-	ABC-type transporter ATP-binding protein	NA	NA	NA	NA
ARD92141.1\|1959051_1959822_-	ABC-type multidrug transport system ATPase component	A0A2H4PQG7	Staphylococcus_phage	4.9e-29	32.8
ARD92142.1\|1959840_1960731_-	glycerophosphoryl diester phosphodiesterase	A0A076G4Q2	Staphylococcus_phage	6.5e-09	26.6
ARD92143.1\|1961244_1962084_-\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	4.6e-49	41.4
ARD92144.1\|1962095_1962356_-	Transposase	A0A1P8CWP5	Bacillus_phage	1.1e-09	36.5
ARD92145.1\|1962624_1963023_+	Diadenosine tetraphosphate (Ap4A) hydrolase related HIT family hydrolase	NA	NA	NA	NA
ARD92146.1\|1963037_1963259_+	hypothetical protein	NA	NA	NA	NA
ARD92147.1\|1963270_1963630_-	hypothetical protein	NA	NA	NA	NA
ARD92148.1\|1963692_1964382_-	LSU ribosomal protein L1P	NA	NA	NA	NA
ARD92149.1\|1964768_1965194_-	LSU ribosomal protein L11P	NA	NA	NA	NA
ARD92150.1\|1965329_1966094_-	ABC transporter permease protein	NA	NA	NA	NA
ARD92151.1\|1966093_1966972_-	bacitracin transport ATP-binding protein	A0A2K9L0W2	Tupanvirus	1.9e-05	26.4
ARD92152.1\|1967038_1967248_-	hypothetical protein	NA	NA	NA	NA
ARD92153.1\|1967281_1967803_-	Peptide methionine sulfoxide reductase	NA	NA	NA	NA
ARD92154.1\|1967977_1968835_-	RNA binding domain protein	NA	NA	NA	NA
ARD92155.1\|1968879_1969338_-	Acetyltransferase GNAT family	NA	NA	NA	NA
ARD92156.1\|1969422_1969980_-	ribosome recycling factor	NA	NA	NA	NA
ARD92157.1\|1970135_1970852_-	uridylate kinase	NA	NA	NA	NA
ARD92158.1\|1970936_1971389_-	hypothetical protein	NA	NA	NA	NA
ARD92159.1\|1971518_1972706_-	acetate kinase	NA	NA	NA	NA
ARD92160.1\|1972864_1974052_-	AckA1 acetate kinase	NA	NA	NA	NA
ARD92161.1\|1974243_1975182_-	Adenine-specific methyltransferase	NA	NA	NA	NA
ARD92162.1\|1975269_1975521_-	hypothetical protein	NA	NA	NA	NA
ARD92163.1\|1975621_1977463_-	GTP-binding protein TypA/BipA-like protein	A0A1S5SF82	Streptococcus_phage	1.2e-17	35.4
ARD92164.1\|1977630_1978104_-	hypothetical protein	NA	NA	NA	NA
ARD92165.1\|1978226_1979066_-\|transposase	transposase for insertion sequence element IS981O	A0A1P8CWQ3	Bacillus_phage	4.6e-49	41.4
ARD92166.1\|1979077_1979338_-	Transposase	A0A1P8CWP5	Bacillus_phage	8.4e-10	37.6
ARD92167.1\|1979374_1979584_-	hypothetical protein	NA	NA	NA	NA
ARD92168.1\|1979831_1980722_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD92169.1\|1980782_1981241_-	hypothetical protein	NA	NA	NA	NA
ARD92170.1\|1981255_1981870_-	putative extracellular protein	NA	NA	NA	NA
ARD92171.1\|1982209_1982938_-	Two-component system response regulator LytTR family	NA	NA	NA	NA
ARD92172.1\|1983130_1983352_+	hypothetical protein	NA	NA	NA	NA
ARD92173.1\|1983385_1984357_+	glucokinase	NA	NA	NA	NA
ARD92174.1\|1984359_1984746_+	Rhodanese-related sulfurtransferase	NA	NA	NA	NA
ARD92175.1\|1984861_1985308_-	non-heme iron-binding ferritin	A0A0A7RTZ1	Clostridium_phage	1.6e-16	32.6
ARD92176.1\|1985473_1986061_+	Aspartic endopeptidase MEROPS family A24 (type IV prepilin peptidase family)	NA	NA	NA	NA
ARD92177.1\|1986100_1986955_-\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA
ARD92178.1\|1987096_1988191_-	Nucleotidyltransferase/DNA polymerase for DNA repair	NA	NA	NA	NA
ARD92179.1\|1988266_1988758_-\|tRNA	Ala-tRNA(Pro) hydrolase	NA	NA	NA	NA
ARD92180.1\|1988833_1990327_-	arginine/ornithine antiporter	NA	NA	NA	NA
ARD92181.1\|1991910_1992855_-	carbamate kinase	NA	NA	NA	NA
ARD92182.1\|1992872_1994453_-	arginine/ornithine antiporter	NA	NA	NA	NA
ARD92183.1\|1994584_1995649_-	ornithine carbamoyltransferase	NA	NA	NA	NA
ARD92184.1\|1995814_1997047_-	arginine deiminase	NA	NA	NA	NA
ARD92185.1\|1997261_1998116_+\|transposase	transposase for insertion sequence element IS982B	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP016685

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. CP015894

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection