CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP022040	Prevotella melaninogenica strain FDAARGOS_306 chromosome 1, complete sequence	4 crisprs	WYL,DEDDh,PD-DExK	0	0	2	0
CP022041	Prevotella melaninogenica strain FDAARGOS_306 chromosome 2, complete sequence	12 crisprs	PrimPol,csa3,DEDDh,cas3	2	2	3	2

1. CP022041

CRISPR-Cas detection and classification

Crispr_ID: CP022041_1

• CRISPR_ID: CP022041_1
• CRISPR_location: 171268-171358
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_1

Consensus_repeat	Method
AGTTGACAAGTGAACAAGTTGCTTG	CRISPRCasFinder

spacers of CP022041_1

>1.1|171293|41|CP022041|CRISPRCasFinder
GTGAACAAGTTGCTTGAGAAGAAGACAAAGGAACTTTGAAA

CRISPR arrays and Neighbor proteins around CP022041_1

CRISPR arrays

The CRISPR arrays of CP022041_1

>merge|CP022041|1|171268-171358|CRISPRCasFinder
AGTTGACGAGTAAACGAGTTGACAAGTGAACAAGTTGCTTGAGAAGAAGACAAAGGAACTTTGAAAAATTAACAAGTGAACAAGTTGACAA

>CP022041|1|1|171268-171358|CRISPRCasFinder
AGTTGACGAGTAAACGAGTTGACAA	GTGAACAAGTTGCTTGAGAAGAAGACAAAGGAACTTTGAAA
AATTAACAAGTGAACAAGTTGACAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18063.1|174335_175280_-|type-IX-secretion-system-membrane-protein-PorP/SprF	unknown	unknown	unknown
CP022041.2|ASE18070.1|183144_183627_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18067.1|180163_180871_+|glycosyl-hydrolase-family-25	unknown	unknown	gnl|CDD|119375
CP022041.2|ASE18060.1|166535_167960_+|alanine:cation-symporter-family-protein	unknown	unknown	gnl|CDD|376500
CP022041.2|ASE18058.1|164370_165453_-|tRNA-2-thiouridine(34)-synthase-MnmA	unknown	unknown	gnl|CDD|234664
CP022041.2|ASE18068.1|180935_182321_+|zinc-ribbon-domain-containing-protein	unknown	unknown	gnl|CDD|372305
CP022041.2|ASE18053.1|148663_151972_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
CP022041.2|ASE18065.1|177512_178328_+|TatD-family-deoxyribonuclease	unknown	unknown	gnl|CDD|223162
CP022041.2|ASE18062.1|171447_173928_+|ferrous-iron-transport-protein-B	unknown	unknown	gnl|CDD|223447
CP022041.2|ASE18064.1|176284_177259_+|polyprenyl-synthetase-family-protein	unknown	unknown	gnl|CDD|376322
CP022041.2|ASE18057.1|161450_163052_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18889.1|175382_176219_+|energy-transducer-TonB	unknown	unknown	gnl|CDD|367555
CP022041.2|ASE18055.1|155251_158962_-|T9SS-C-terminal-target-domain-containing-protein	unknown	unknown	gnl|CDD|275380
CP022041.2|ASE18052.1|146795_148508_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|373012
CP022041.2|ASE18069.1|182719_183103_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18066.1|178474_179167_+|(d)CMP-kinase	unknown	unknown	gnl|CDD|234579
CP022041.2|ASE18054.1|152977_154678_-|putative-transporter	unknown	unknown	gnl|CDD|179654
CP022041.2|ASE18061.1|169777_170209_-|DoxX-family-protein	unknown	unknown	gnl|CDD|225168
CP022041.2|ASE18056.1|159078_161454_-|T9SS-C-terminal-target-domain-containing-protein	unknown	unknown	gnl|CDD|173804
CP022041.2|ASE18059.1|165475_166393_-|YitT-family-protein	unknown	unknown	gnl|CDD|224203

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18067.1|180163_180871_+|glycosyl-hydrolase-family-25	gnl|CDD|119375	cd06413, GH25_muramidase_1, Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues.	3.72307e-53
CP022041.2|ASE18060.1|166535_167960_+|alanine:cation-symporter-family-protein	gnl|CDD|376500	pfam01235, Na_Ala_symp, Sodium:alanine symporter family.	0
CP022041.2|ASE18058.1|164370_165453_-|tRNA-2-thiouridine(34)-synthase-MnmA	gnl|CDD|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	7.58984e-147
CP022041.2|ASE18068.1|180935_182321_+|zinc-ribbon-domain-containing-protein	gnl|CDD|372305	pfam12773, DZR, Double zinc ribbon. This family consists of a pair of zinc ribbon domains.	2.91065e-07
CP022041.2|ASE18053.1|148663_151972_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
CP022041.2|ASE18065.1|177512_178328_+|TatD-family-deoxyribonuclease	gnl|CDD|223162	COG0084, TatD, Mg-dependent DNase [DNA replication, recombination, and repair].	2.82176e-84
CP022041.2|ASE18062.1|171447_173928_+|ferrous-iron-transport-protein-B	gnl|CDD|223447	COG0370, FeoB, Fe2+ transport system protein B [Inorganic ion transport and metabolism].	0
CP022041.2|ASE18064.1|176284_177259_+|polyprenyl-synthetase-family-protein	gnl|CDD|376322	pfam00348, polyprenyl_synt, Polyprenyl synthetase.	5.92169e-94
CP022041.2|ASE18889.1|175382_176219_+|energy-transducer-TonB	gnl|CDD|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	2.07133e-13
CP022041.2|ASE18055.1|155251_158962_-|T9SS-C-terminal-target-domain-containing-protein	gnl|CDD|275380	sd00033, LRR_RI, leucine-rich repeats, ribonuclease inhibitor (RI)-like subfamily. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	6.12428e-13
CP022041.2|ASE18052.1|146795_148508_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|373012	pfam14322, SusD-like_3, Starch-binding associating with outer membrane. SusD is a secreted polysaccharide-binding protein with an N-terminal lipid moiety that allows it to associate with the outer membrane. SusD probably mediates xyloglucan-binding prior to xyloglucan transport in the periplasm for degradation. This domain is found N-terminal to pfam07980.	2.87202e-28
CP022041.2|ASE18066.1|178474_179167_+|(d)CMP-kinase	gnl|CDD|234579	PRK00023, cmk, (d)CMP kinase.	6.99332e-120
CP022041.2|ASE18054.1|152977_154678_-|putative-transporter	gnl|CDD|179654	PRK03818, PRK03818, putative transporter; Validated.	0
CP022041.2|ASE18061.1|169777_170209_-|DoxX-family-protein	gnl|CDD|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	1.48841e-13
CP022041.2|ASE18056.1|159078_161454_-|T9SS-C-terminal-target-domain-containing-protein	gnl|CDD|173804	cd07478, Peptidases_S8_CspA-like, Peptidase S8 family domain in CspA-like proteins. GSP (germination-specific protease) converts the spore peptidoglycan hydrolase (SleC) precursor to an active enzyme during germination of Clostridium perfringens S40 spores. Analysis of an enzyme fraction of GSP showed that it was composed of a gene cluster containing the processed forms of products of cspA, cspB, and cspC which are positioned in a tandem array just upstream of the 5' end of sleC. The amino acid sequences deduced from the nucleotide sequences of the csp genes showed significant similarity and showed a high degree of homology with those of the catalytic domain and the oxyanion binding region of subtilisin-like serine proteases. Members of the peptidases S8 and S35 clan include endopeptidases, exopeptidases and also a tripeptidyl-peptidase. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The S53 family contains a catalytic triad Glu/Asp/Ser. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.487e-22
CP022041.2|ASE18059.1|165475_166393_-|YitT-family-protein	gnl|CDD|224203	COG1284, COG1284, Uncharacterized conserved protein [Function unknown].	5.96702e-58

Protein sequences

>CP022041.2|ASE18061.1|169777_170209_-|DoxX-family-protein
MKCLELLFPKAESTKTSLILLASRLVFGLTFASHGLDKLQHFSETAAHFPAPFGLSGEVAVGLSIFGELVCGLAFVFGFLTRLALLPMIFTMLVAFTTVHGGSVSNGELAFLYLVIFVLSWFAGAGKFSVDGIIRSKISGGNS
>CP022041.2|ASE18060.1|166535_167960_+|alanine:cation-symporter-family-protein
MIELFSADGWLNQAIVSVNYFTWTYILVAGLVICALWFTWRTRFVQFRMIGEMVRLLGDSTGTHDEGEKHVSSFQAFAVSIASRVGTGNLAGVATAIAIGGPGAVFWMWVIALLGSATAFIESTLAQLYKRRHADSFIGGPAYYILHGMHCKWMAKLFAVLITMTFCMAYISIQSNTICGAMQKAFSIDPTWMGGALAILSLAIVFGGIQRIAKVSSVLVPLMAVSYVLLALVIIVMNIQLIPHVFRLIVENAFGFEQVAGGGLGATMMNGIKRGLFSNEAGEGSAPNIAATASTTHPVKQGLIQSLGVFTDTLLVCSCTAFIIIISGLYVNNSESGILLTQVALESEVGAAGPIFIAIAIFFFAFSSIIGNYYYGEANVRFLTQKPSAILALRVITGGVMVMFGAIASLDLVWSIGDFFMALITICNLIAILTLGKYAFRLLDDYRQQKRAGVKSPVFKRETMPDIAKDIECW
>CP022041.2|ASE18059.1|165475_166393_-|YitT-family-protein
MVRKRKNKFRDVREFLMIALAMLIGSFGWCAFLLPHHITIGGIAGIASVIQWGLDIPVQYTYLTINGILLFVALKILGWKFCVRTIFAVLVFAFSTSVLREVFAGHPLFSDEPFLACVVGGVLLGVGVSIALQYNASSGGSDVIAAMIHKYRDVSLGRVILACDLCIISSSYLVLENWEKVIYGYIVLFVMTYVVDYLINGMRGSVQFFVISEHWGEIGSAINNDVDRGCTVIEARGFYTGKKVGMLFVIARRSEAHSIYQVIDEIDPNAFVSQGAVNGVYGMGFDRMKVAHKKKTADEKVRTKE
>CP022041.2|ASE18058.1|164370_165453_-|tRNA-2-thiouridine(34)-synthase-MnmA
MNIQELEGKRIAVLLSGGVDSSVVVYEFARLGLHPDCFYIKIGPEEKEDWDCNSEEDLEMATLVTRRFGCKLEVIDCHKEYWDQVTRYTMEKVKAGFTPNPDVMCNRLIKFGAFDEKMGHDYDLIATGHYAQTEWIDGRKWLTTSPDPVKDQTDFLAQIYDWQLKKAIFPIGHYEKNEVREIAERENLINAHRKDSQGICFLGNIDYNEYVRRYLGEEIGDVIELETGKKIGEHKGLWFHTIGQRKGLGLGGGPWFVIKKDVTKNILYVSHGYDPATAYKKDFPLHDFHFLTEGITTLPEKITFKIRHTPEYHPATVEQLSDGRCIIHSTENIHGVAPGQFCVVYDEQHHRCFGSGEITL
>CP022041.2|ASE18057.1|161450_163052_-|hypothetical-protein
MKQVYYFIFLMLLAFSSVNVKADTTVRVKVDDINRVSVKVNYLPVVNLANGTNEITVPQYGALTIEAKQGYYLKSVLKTIDNDNSAPQTINNLTSCNIYVSDADNNKLFTVKSADLAKARTGSCTVNVDNASKVRVSRNESRTSVELQNGENTVKWIPNTEKTLVITNANYGDAPIYKVTLDGNDVTPSSGQYFVTLTAGCVVDIKADYPNVSYPVKFNFTDEKAKGVISKVMADGEEVKNYNDADFKLKAGTKLSLTFDQRNYALDAFKVNGTATTIYGTYECYVKDNLVFDIQAHKYATVKAVLTVDKAANITAYEGQSYNNKVITLQNGSNNIELGEKNNLIQIKPNSGCKIESIKANGTPVTANYEGAYEIRLTDGMTIEVTTSAIVRDQKATVFIDDISLANYGFNFYRSDHSTIKMQTGENTVMFSADDHHFMLGAYGNDLSKMVVKLNGTILAPSYPGGTSFEFDLKNNDRLDVLLKGDTAGIDAIEAVKQGKAVVYRLDGKRIEGTQLPNGVYIINGKKVIVNKR
>CP022041.2|ASE18056.1|159078_161454_-|T9SS-C-terminal-target-domain-containing-protein
MRKILLTVFCLCSVGLAYGQSKLDLQSQLELFKLRNTSIPTYNSRTRSFERPKSVPENTMAMVEMKDQNDRADLEAQGVKVLRVRGNIAIVVAPIKDIERIAGLKCVRRMELPRRVYQKMDVVRKEIGVDKIHKGIDLPQAYTGKGVVTGIVDGGIDPNHINFLKPDGSTRFGYISKITASQSNKDGYQFDNYYPRVVLDTLTNRDNAYAIEDFTTDSYTTFHGTHTTGIMAGGYKGNINYAKTNDNDRSYKVTGPNPFYGCATESELVASCGDLRDQYIAFGVDDVVQYAKLSGKKPKPCVINLSLGSNIGVHDSTSVMNRFLAEEGKHAIICVAAGNEANMGIALKKNFTAADETVKTFLTPMQPDTLRSGGKTYFNLRNGQIAAYSNDSTEFELQIVVTNTKRGNRVVSRIPLPNNTNGQPITYASGGEYSMSGAVINQGFAKAFDGYVTAASAIDPETGRYYAMAQIMTSDNQKDNKDGNYKLALLITSKKPGQRVEVYSDAQFIYFDSNKQEGFVSGTRNGSISDMACAANIVTVGSYNVRNHWSSLDGFVYGYNKRGDEDDFPEGEASRFSSFGTLADGRNLPHVCAPGASIISSVNTYAVENTDLGYTDMALQGKLEKGGKKYYWHQSLGTSMATPVVAGAIALWLEANPSLTVKDVIRIIQQTARKDDYVTKTGDPVQWGAGKFDAYAGLKQVLKEKETNGINGVRYAESQAVPVITMTGERSFSAFLAGAKQLNLRAYSLSGQLVHSLSAQGDELNVNASSWNKGVYLIQVNGGKAQRIVIY
>CP022041.2|ASE18055.1|155251_158962_-|T9SS-C-terminal-target-domain-containing-protein
MKHKFTFLPSFLLLVMAMLWSSLAAHAQDEVLIRFHTNVPEKAKNSGVAAQVSFVLGSKSDKADVSIDYGSGDTEVEINKAIVENDHGEQAIKGTLCTDVVSDAGWVTIKGNPDDLYFFNASGNEIDQIQFNDNLKLQVLNLEHNNLKSLNIDRLQSLNIIYLQDNPFSATTPLMIGRMPNLMVLEVPQIGHISPDFTLKNFPNLRSFDAYHTISLKTADPTGCPYLQRLSLDMTSVESVDLSKNSLLQILNVGDSRVKTLDLSHNPEITQLYISHSSGAVNTDVKFETIDVSHCPKLYYFYCGGNNLKELDLRNNPELFTLSCDRNLLRNLDVSQNPKLYSVNVRYNYMDFATLPEPGNWFEYYHEQNPMELNDTYKVGDVIDLSKRVLRANTTTQARLYRVPKDDPTKPVELDDSYYSYEGGKVTLKKELNEEVFVQFTNSRLRDYPIRTENFRVKTVAEFGKDVKAIQLASLGDAGSPLKMSVGILGATAANPVTVKVDLGDGNTTPFEIKDERPATANIVTTRTGAGDIIVYVPQDKYVTSLESDGQYIDNIDLSALTELRTLTLKRANLTTIDLSYNNKLEKLDLSYNQLNRVDLRGPSSYFNKSKLTDINISHNQVDSLLFNTIYGVTKLNVSHNKLNKLDLKDADNLRMLDISYNKFTRLLLNHSELIEDINVANNELTEVKIPPVAPVKKLNVSGNYFTLANMPNDFGLTRGNFIYAPQNVLQISTSSPGIDLSEQYITKDGATTNFVWKKKDGTPLQLGKDYTITNGSAKFTNLALDSIYCEMTHAAYPDFEGKNVFKTTNVHPIAFPKYELASFTTVNQTDSVVLSLASYVPGKSVYFEWGGNGNVTQYTLGEKYKIFQAKSKANTKVRVLVAEADDKVKVFSVANVKMTDVDLTGLKEAKLISITQAGLTSVKLPAAPNLTDLNFDGNELTDIDLSPFPKLFAVSLIGNKIKNFDLSKAPNLGIAYLSSNKMKEIKLDNPKLESLDLSDNDLENVSLDKLPQLEQLWLNANKLTKVDVSKNTNLRVLNVVGNRLKFSTMPLPNNNGKRFDRYSYNLQAPIDVKCVNGKVDLSSEAVVGGEMTTYHWFIGNVTYRDGELQGEKLEVNDEYTVENGVTTLKLTQSITNLVCVMSNDNFPNALIYTNYIAFTPATGIDAVTADKDVKIQFFDGAISVLGAQNSTVAIYSIDGKLVYQGKVADDSTRISLARGTYIVRVGNKAAKISVK
>CP022041.2|ASE18054.1|152977_154678_-|putative-transporter
MDWLIDIFSAEKQDTVAHIMLLYSIVIALGIYLGKIKIGGISLGVTFVLFVGILAGHIKFTGPIPVLTFVQDFGLILFVFMIGLQVGPGFFESFGKGGLKLNILSTVAILLNVLVMFACYYIFFDTQDKTNLPMMVGTLYGAVTNTPGLGAANEALHSVFKNGMNFDIASGYACAYPLGVVGIISATIAIRYICKVNLQEENEKLNEEEAENPHAKPYTMYLKVQNAYIAGRKLEEISEFLNRDFVCTRLMHEGVLSVPTLDNIFELGDEILVVSAEADAAAIRAFIGPEIEVDWHEEDQPQQLVSRRIVITNSKINGKTLGDIHFRSVYGVNVTRISRQGMDLFAGRNHRFIVGDRIMVVGPEENVNRVASMMGNSEKRLNAPNIATIFVGIIVGIIFGTLPIAIPHMPVPMKLGLAGGPLVIAILIGRFGYRMGLVTYTTTSANMMLREIGLALFLASVGIKAGATFWDTVVQGDGLKYVYTGFIITIVPILIVGTIARLKYKFNYFTIMGMLAGTYTDPPALAYANSICAGEAPAVGYSTVYPLSMFLRIFLAQVIVLFFCQI
>CP022041.2|ASE18053.1|148663_151972_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MEKRITLFLFGLILSLGTAFGQAKINGTVVSQDDGEAVIGASVMVQGTTTGTVTDIDGHFTIDVPAGKKLVVSYIGMVTQTVTAKDGMKVVLSNDNHQLTEVVVTGMTQQDKRLFSGAATKIDASKAKLDGMADVSRSLEGRAAGVSVQNVSGTFGTAPKIRVRGNTSIFGSSKPLWVVDGVIMEDIANVDASSLSSGDAKTLISSAIAGLNADDIESFQILKDGSATSIYGARAMAGVIVVTTKKGKAGQSHLSYTGEYTLRLKPSYKNFNIMNSQDQMEVYRELEKKGYLNYAEIANASTSGVYGRMYQLISEYDATKGQFGLENTQKARDAYLRAAEYRNTDWFDQLFSSSIMHNHSVSASGGTDKGQYYASLSAMYDPGWYKSSRVQRYTGNINTTYNINKKVGLNLIANASYRKQRAPGSLSRTIDPSTGAVSRAFDINPYSYSLNTSRTLDPTESYTRNYAPFNIFNELNNNYMDLNVHDFRIQTSIDYKPITKLKLTALVAVKSAASTMEHVVRENSNQALAYRAMGTTTIRDANPYLYTDPDNPFALPESILKEGGILDRTGNHFFGWDTRLSAAYNDVFNDTHIVNLYAGVESNSVDRKATFDREWGMMFDAGEIAKLNYRAFKMFQEKGSDYYGLSNTHIRSLAYFGTGTYSYKGRYQMTGTFRYEGTNYLGKATSARWLPTYNVSGAWNAHEEEWFNKVFKQALTHATFRLSYSLTGDRPPVTNSLPIFTATVPWRPFTSIQETGYDEQFGNKNLTYEKKREFNLGFDFGFLDNRINLTTDFYWRRNSDLIGYVNHPQLGSYNLANVASMKSNGMELSLNTHNIKTKDFSWESNFIFSWTHNEITSLFTHARVIDLVQGTGYSLVGYPVNSIFSIPFAGLDGEGLPTFMNEDGRRTISGLNLQERDQEKIKYLKFEGPADPTTTGSFGNVFRYKNWDLNVFVTYSFGNKVRLNHIFSNRYDDMDALPKEFRNRWTYSGDETLTTIPVIASRRQNRNNSQLDVAYNAYNYSDVRIAKGDFIRMKEISLGYTFPAAMIRTIGVSSLALKLQATNLFLFYSDKKLNGQDPEFFNTGGVAAPVPKQFTMTLRLGL
>CP022041.2|ASE18052.1|146795_148508_-|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKIKNIIYKGSLMLASVAILASCSDQLDTLPDNRTTLDTPKKIAGLLVTAYPDRTPTLFNEWMSDNTDYMGAQNSQGNRGGDQYFFWQEQTEGGNDSPEQVWMLYYEGVYKANEALAAIEDQGGPKNDILRNSKGEALLIRAYDHFILANEFCRPYNGKTSTKDAGLYYATGIADFSAAAEQSNRGTVADVYAKIAADIEAGIPLLNDTYEVPKYHFNKQAAYAFATRFYLYYEKWEKAKEYADKLLGSNPAASLRDYRALQAMPLSKSEQAVKIAEAYCSASADCNLLVQTSVSNAGMALAPWLTSKRYTLTNYLAETELFQSNNIWGTSSNLIWKPFTVNSGESNFALLMKLPREFEIRNTTTGSGYLRTLNVDFTMDEALLNRAEAEIMLGQNDAACADMTIWMKNFFNTNVTLTPTSVQTYFKTVPYAYADAAKMVPSFKKHINPRFTIGAEGSVQESLLQCLLNFRRIETVHQGMRWMDIRRYNIEIPRRLIGANGRPSKNLDWLEKDDPRQVVQIPQSIREAGVAGNPTKALVAGAKLVDLSQYKLPVLSAVNQYSAPVSAHSF
>CP022041.2|ASE18062.1|171447_173928_+|ferrous-iron-transport-protein-B
MKLSELKTGETGVIVKVSGHGGFRKRIIEMGFIKGKTVEVLLNAPLQDPVKYKVMGYEVSLRHSEADQIEVLSDVKTHSVGNEEEQEDNQVEMDSTTDDSTDKELTPEKQSDAVRRKSHTINVALVGNPNCGKTSLFNFASGAHERVGNYSGVTVDAKVGRAEFDGYVFNLVDLPGTYSLSAYSPEELYVRKQLVDKTPDVVINVIDSSNLERNLYLTTQLIDMHIRMVCALNMFDETEQRGDHIDAQKLSELFGVPMIPTVFTNGRGVKELFRQIIAVYEGKEDESLQFRHIHINHGHEIENGIKEMQEHLKKYPELCHRYSTRYLAIKLLEHDKDVEQLVSPLGDSIEIFNHRDTAAARVKEETGNDSETAIMDAKYGFINGALKEANFSTGDKKDTYQTTHVIDHVLTNKYFGFPIFFLVLLVMFTATFVIGQYPMDWIEAGVGWLGEFISTNMPAGPVKDMIVEGVIGGVGAVIVFLPQILILYFFISYMEDCGYMSRAAFIMDRLMHKIGLHGKSFIPLIMGFGCNVPAVMATRTIESRRSRLITMLILPLMSCSARLPIYVMITGSFFALKYRSLAMLSLYIIGVLMAVAMSRLFSAFVVKGEDTPFVMELPPYRFPTWKAIGRHTWEKGKQYLKKMGGIILVASIIVWALGYFPLPDDPNMDNQARQEQSYIGRIGKAVEPVFRPQGFNWKLDVGLLSGMGAKEIVASTMGVLYSNDGSFSDDNGYSSETGKYSKLHNLITKDVATMHHISYEEAEPIATLTAFSFLLFVLLYFPCVATIAAIKGETGSWGWALFAAGYTTALAWIVSAVVFQVGMLFM
>CP022041.2|ASE18063.1|174335_175280_-|type-IX-secretion-system-membrane-protein-PorP/SprF
MKKIVFTLLLALFAVVIRAQESQTEYNFLRLPVSAHAAALGGENITIIEDDPSLMFSNPALASSVSDKTVGLSYMNYMRGAHYMGASYTKALGEKATLAGGVQYMNYGKMKEVDANNVQTGTFNASEIAVEGIFSYELARNLVGGITAKFITSYIGSYNSMAVGVDLGLNWYEPERQWSVSLVAKNLGGQIKAYEEEYGKMPIDVQVGVSKTFAALPVRVSATLVDLTHYDYRFINHLNLGAEVLLSESIWVGGGYNFRKADEMTIGKADNASAHGAGFSVGAGINLEQFKLNLAYGKYHAASNSILVNLAYSF
>CP022041.2|ASE18889.1|175382_176219_+|energy-transducer-TonB
MYNGRKRCLVYLILEIKKSNRADLENKRWVGFLLGIIVALSFFFVAMEYNATGSDDDSANTKAIKNVTLHDMDMLPAIDQQDLAKTQEDKKPTMEDLLNLKRRDIPNKVTPHDAGSMNSNDKKTGAPQVSNEPIVMPMVTTTTEPPKIKEEAKKEMEKMTDDNSDKVVERYDDKVSKRILSETPTPPGGWVEFMKWLTKTLQYPAAAKENKLQGTVNITFIINADGTVDDVRIKSGKVPVLNDEVLRVLKTMGKWKPGIEKNKPCRSLIEIPFVFQLA
>CP022041.2|ASE18064.1|176284_177259_+|polyprenyl-synthetase-family-protein
MYTANEILSKVNEYINNLTYDRKPQSLYEPIKYVLSLGGKRIRPTLMLLSYNLFKDDPETILSPACALETYHNYTLLHDDLMDDAPLRRGQQTVHVRWDANTAILSGDSMLVLAFERMAQCDSRHLSEVLRLFTVTALEIGEGQQYDMEFENRNDVKEEEYIEMIRLKTSVLLACAMKIGAILADAPAEDVENLYKFGEQIGLAFQLQDDYLDVYGDPKVFGKKIGGDIICNKKTYMLINAFNKANARQCKELEKWIGCENFNHEEKVAAVTELYNSIGVDKMAIERINYYFDEANKYIAAVNLPDERKAELLAYAQKMLHRKW
>CP022041.2|ASE18065.1|177512_178328_+|TatD-family-deoxyribonuclease
MIIDTHAHLDVEDFADDLPEVISHAHEAGVGKIFLPAIDLKSVDTVLAVCRQFPDTCYPMIGLQPEEVRDDWREVLDAMHERILLSLRQKAEGTAKPGETVIAIGEVGLDFYWTREYEKQQLAAFEEAVKWSVETRLPLMIHCRKAQNEMLHIMRPYEKELPGGVFHCFTGNQKEAEEFLRFDRFVLGVGGVSTFKSSHLREDLPAAVPLDRIVLETDSPYMAPVPHRGKRNESAFIVEVMRTLALSYGVDEAEFARQTNENVRRVFGVGC
>CP022041.2|ASE18066.1|178474_179167_+|(d)CMP-kinase
MKKITIAIDGFSSCGKSTMAKDLAKEIGYIYVDTGAMYRSVTLYALRHNLFNTDGTIREEELQAQMKDINISFQLNKETGRPDTYLNGENVENEIRTMEVSSHVSPIATLAFVRKALVEQQQRMGAEKGIVMDGRDIGTVVFPNAELKIFVTASAEVRAQRRYDELKAKGMEADFADILKNVQERDYIDSHRETSPLRKADDALELDNSQLTIAEQKQWLYNQYLKAAEA
>CP022041.2|ASE18067.1|180163_180871_+|glycosyl-hydrolase-family-25
MKLKKIIMLIACIFSFAGLKAQYTIQCEDTCSHVHGLDMSHYQGDVWWETVAENSNHKLNYVYLKATEGGTRIDQRYLENIEAAQRYGMNVGSYHFYRPAIPQEEQLRNFRMQCRPQDQDLIPMVDIETTGGLSTEALRDSLQRFLVLMTQEYGVKPLVYTYTNFYNRYLSGALDGYKLFIAQYNGREPELNDGRDIFAWQYTGKGRINGVRGYVDKSRLMGNHSMRELRFRRKR
>CP022041.2|ASE18068.1|180935_182321_+|zinc-ribbon-domain-containing-protein
MIIKCPECGHQVSDKAPVCPSCGVEIAGHIIKCSHCGELYLKEESSCPNCHHTEHHVESSVTAAEHHTSEATNDSKVQEPVVLMSVDKGEVTGNDDVIIPVEETEEHETDNYDNKTQDTINEPNTEEEAVDADFIMDDNADEEVIANAEAIAEDEEESTPDKNNHLSLAVSLLIAAITAAVLLFLYNQGVGASKANNEQEAFAQAMSSSEPTVLKNYLKENPSASKAHRDSISARLKVLTTTTQNMQQSDNDLSVALTSNSKEVLQQFIAKYPDSKHRGELEAKIDEIDWAGAVAKNNENAYLGYKAQHPNGIHSKEADEKLKNILTPEMAEESAAAKVTDGERAKAVAAVRQLLQGINSKSTDKISGAVAPSLNFLGSGGATVKDIRRYMTDRLYQADVKTINWHLGSPTEVTKNSNEAGADIRLKIPATLDIDRKGGKSKRSYVISATIKNGRITHINW
>CP022041.2|ASE18069.1|182719_183103_-|hypothetical-protein
MKKKPTYKVPVSICAIVLVVGAIVLAVLMETREMAPPRKYEVDMSGEVIGIDNGPKIPVLTKEEEKDEEVKEEKKTEAPKKESSESEETADPENPVIVPNVPEGQTEPVVKAPVPEIKKPTIDQIEN
>CP022041.2|ASE18070.1|183144_183627_-|hypothetical-protein
MKKILLLLTVLLFAMGARAQKDIVSMADAIKIFQAKTLQVGKQVLEKQGYSYKGVSSDEFGKDYNWVKNMNLTSDFLPTAMGRGNSSMVLLAQNGKTVYVYVFNRTAFAGLQAQVKAMGYDMGNAVKGDKTTLICTKDNQPTISFLTLQQPLPYCVQITE

Crispr_ID: CP022041_2

• CRISPR_ID: CP022041_2
• CRISPR_location: 298657-298793
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_2

Consensus_repeat	Method
CGGTGTTGTCTTAACTCCTTTAACTCCATTTAATTCCTTAACTCCACATC	CRISPRCasFinder

spacers of CP022041_2

>2.1|298707|37|CP022041|CRISPRCasFinder
CTTTCCTCCTTAACTCCACATCAATCCTATGAGTCAG

CRISPR arrays and Neighbor proteins around CP022041_2

CRISPR arrays

The CRISPR arrays of CP022041_2

>merge|CP022041|2|298657-298793|CRISPRCasFinder
CGGTGTTGTCTTAACTCCTTTAACTCCATTTAATTCCTTAACTCCACATCCTTTCCTCCTTAACTCCACATCAATCCTATGAGTCAGCGGTGTTGTCTTAACTCCTTTAACTCCATTTAACTCCTTAACTCCACATC

>CP022041|2|2|298657-298793|CRISPRCasFinder
CGGTGTTGTCTTAACTCCTTTAACTCCATTTAATTCCTTAACTCCACATC	CTTTCCTCCTTAACTCCACATCAATCCTATGAGTCAG
CGGTGTTGTCTTAACTCCTTTAACTCCATTTAACTCCTTAACTCCACATC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18158.1|312099_312531_-|NUDIX-hydrolase	unknown	unknown	gnl|CDD|223979
CP022041.2|ASE18160.1|314278_316759_+|bifunctional-UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine-ligase/alanine-racemase	unknown	unknown	gnl|CDD|237026
CP022041.2|ASE18144.1|285410_286022_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18148.1|289752_291369_-|ABC-F-family-ATPase	unknown	unknown	gnl|CDD|237894
CP022041.2|ASE18153.1|298813_300037_-|MFS-transporter	unknown	unknown	gnl|CDD|340952
CP022041.2|ASE18150.1|292713_294258_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18157.1|309456_311157_-|hypothetical-protein	unknown	unknown	gnl|CDD|224563
CP022041.2|ASE18895.1|312547_312760_-|DUF3791-domain-containing-protein	unknown	unknown	gnl|CDD|372250
CP022041.2|ASE18159.1|312939_313752_+|GSCFA-family-protein	unknown	unknown	gnl|CDD|378080
CP022041.2|ASE18146.1|287933_289097_-|molecular-chaperone-DnaJ	unknown	unknown	gnl|CDD|237660
CP022041.2|ASE18147.1|289111_289690_-|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl|CDD|271355
CP022041.2|ASE18156.1|308639_309038_+|pilus-assembly-protein-HicB	unknown	unknown	unknown
CP022041.2|ASE18141.1|281468_282737_-|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275383
CP022041.2|ASE18149.1|292435_292660_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18154.2|300385_303865_-|beta-galactosidase	unknown	unknown	gnl|CDD|236673
CP022041.2|ASE18145.1|286398_287691_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	unknown	unknown	gnl|CDD|273659
CP022041.2|ASE18155.1|304286_307778_-|hypothetical-protein	unknown	unknown	gnl|CDD|379625
CP022041.2|ASE18142.1|283027_284158_-|leucine-rich-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|275383
CP022041.2|ASE18143.1|284374_285430_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	unknown	unknown	gnl|CDD|378065
CP022041.2|ASE18896.1|313763_314195_+|transcriptional-repressor	unknown	unknown	gnl|CDD|223806

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18158.1|312099_312531_-|NUDIX-hydrolase	gnl|CDD|223979	COG1051, COG1051, ADP-ribose pyrophosphatase [Nucleotide transport and metabolism].	1.41016e-36
CP022041.2|ASE18160.1|314278_316759_+|bifunctional-UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine-ligase/alanine-racemase	gnl|CDD|237026	PRK11930, PRK11930, putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional.	0
CP022041.2|ASE18148.1|289752_291369_-|ABC-F-family-ATPase	gnl|CDD|237894	PRK15064, PRK15064, ABC transporter ATP-binding protein; Provisional.	0
CP022041.2|ASE18153.1|298813_300037_-|MFS-transporter	gnl|CDD|340952	cd17394, MFS_FucP_like, Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters. This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.69592e-67
CP022041.2|ASE18157.1|309456_311157_-|hypothetical-protein	gnl|CDD|224563	COG1649, COG1649, Uncharacterized protein conserved in bacteria [Function unknown].	7.33227e-47
CP022041.2|ASE18895.1|312547_312760_-|DUF3791-domain-containing-protein	gnl|CDD|372250	pfam12668, DUF3791, Protein of unknown function (DUF3791). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 71 and 125 amino acids in length.	3.15295e-18
CP022041.2|ASE18159.1|312939_313752_+|GSCFA-family-protein	gnl|CDD|378080	pfam08885, GSCFA, GSCFA family. This family of proteins are functionally uncharacterized. They have been named GSCFA after a highly conserved N-terminal motif in the alignment. Distant similarity to the pfam00657 lipases suggests these proteins are likely to be enzymes.	3.01699e-90
CP022041.2|ASE18146.1|287933_289097_-|molecular-chaperone-DnaJ	gnl|CDD|237660	PRK14289, PRK14289, molecular chaperone DnaJ.	0
CP022041.2|ASE18147.1|289111_289690_-|nucleotide-exchange-factor-GrpE	gnl|CDD|271355	cd00446, GrpE, nucleotide exchange factor GrpE. GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.	5.18116e-46
CP022041.2|ASE18141.1|281468_282737_-|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275383	sd00036, LRR_3, leucine-rich repeats. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	3.05412e-54
CP022041.2|ASE18154.2|300385_303865_-|beta-galactosidase	gnl|CDD|236673	PRK10340, ebgA, cryptic beta-D-galactosidase subunit alpha; Reviewed.	0
CP022041.2|ASE18145.1|286398_287691_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase	gnl|CDD|273659	TIGR01499, Folylpolyglutamate_synthase, folylpolyglutamate synthase/dihydrofolate synthase. This model represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid].	3.32714e-121
CP022041.2|ASE18155.1|304286_307778_-|hypothetical-protein	gnl|CDD|379625	pfam14498, Glyco_hyd_65N_2, Glycosyl hydrolase family 65, N-terminal domain. This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.	1.1523e-49
CP022041.2|ASE18142.1|283027_284158_-|leucine-rich-repeat-domain-containing-protein	gnl|CDD|275383	sd00036, LRR_3, leucine-rich repeats. A leucine-rich repeat (LRR) is a structural protein motif of 20-30 amino acids that is unusually rich in the hydrophobic amino acid leucine. The conserved eleven-residue sequence motif (LxxLxLxxN/CxL) within the LRRs corresponds to the beta-strand and adjacent loop regions, whereas the remaining parts of the repeats are variable. LRRs fold together to form a solenoid protein domain, termed leucine-rich repeat domain. Leucine-rich repeats are usually involved in protein-protein interactions.	6.72654e-54
CP022041.2|ASE18143.1|284374_285430_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein	gnl|CDD|378065	pfam08843, AbiEii, Nucleotidyl transferase AbiEii toxin, Type IV TA system. This family was recently identified as belonging to the nucleotidyltransferase superfamily. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.	3.5386e-20
CP022041.2|ASE18896.1|313763_314195_+|transcriptional-repressor	gnl|CDD|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	6.75173e-21

Protein sequences

>CP022041.2|ASE18150.1|292713_294258_+|hypothetical-protein
MRKQTFKVRLLSLIALCGIVMVFASCSNEDVAQSTVETNTEKNSNLTSFVTGAAATRTSLNYDNGAFFWEAGDHIYVKDDNGTWQKSRNAPTEKTASFKFMVPGKYTNSTTYKVYYPGKNGLNNNVTISGTQSQAQPNSTTHIGEAGDCGTADATRNGGVFNFRLDHQAAILVFQPFTNNTAVKNCYLTKIEVESDNDITDTYTLDTTTGELTGTGSGKTITMTTKGSGSYANGFSLNTSTADVKTNGAYVVIRPGTHALTVRYWIKDYVTNVEGAITKTYDSFKYEKNDYYDMTADINVTDYDGSKYYMWDAQKNYWNGHEWNSANPWQPVLANKSNPNYPVSGSSYFHRTGGFGREDAMNSSCKNLPNANELGWYVKNGDPRWDDDKLWTAMGHLYKGGIWLRNKAYINLITSFNSDQGPSYLDMRDNYARFEVTPIQGAPVGYFASRYFFLPALGKYSDGYLSKIGERGFYWSSSASPVDETWAYSLEFSKSQVIVSPTSSNDGYYIGTFE
>CP022041.2|ASE18149.1|292435_292660_+|hypothetical-protein
MKQNKIKIGYQAPYTEVIVINNETLLAENSFPGQHRPGNHKKGPNANNAKQALEWLEVGDEASSSNEHTSLWED
>CP022041.2|ASE18148.1|289752_291369_-|ABC-F-family-ATPase
MITLSNLAIQFGKRVLYKDVNLKFTPGNIYGVIGANGAGKSTLLRAISGDLEPNKGTVELGPGERLSVLEQDHFKYDEYKVMDTVLMGHDALWQNMKEREELYAKPEMTEEDGNRAADLELKFAEMNGWEAESNAAQLLQNLGVKEELHEKQMSQLSNTEKVRVMLAKALFGKPENLLLDEPTNDLDLETVEWLEDYLGEIDEHQTVLVVSHDRHFLDSVSTQTIDIDFGKVTVFAGNYSFWYESSQLALRQAQNQKMKAEEKKKQLEEFIRRFSANVAKSKQTTSRKKMLERLNVEEIRPSSRKYPGIIFSMEREPGNQILEVENLKAVDEDGTVLFDNVNFNIEKGQKVVFLSRNSKAMTALFEIINGNREPDAGTYNWGVTITTAYLPLDNTEFFDCDLNLVDWLSQFGPGNEVAMKGFLGRMLFKQEEVEKKVNVLSGGEKMRCMIARMQLQNANCLILDTPTNHLDLESIQAFNNNLIGFKGNILFSSHDHEFINTVADRIIELTPKGTIDKLMSYDDYIHDEQIKEQKAGMY
>CP022041.2|ASE18147.1|289111_289690_-|nucleotide-exchange-factor-GrpE
MSKKEKNIKIEGEELELNNEETTQNYAEAQAEDANGEETPAEEELDPLVAAQNDAEQWKDKYIRLVAEFENYKKRTLKEKSELILNGSEKTVAAILPILDDFERATADKTEDPQAIKEGYELIYKKFLKALETLGVNKIETDNADFDVDYHEAIAMVPGMGDDKKGKVIDCVQTGYTLNDKVIRHAKVAVGQ
>CP022041.2|ASE18146.1|287933_289097_-|molecular-chaperone-DnaJ
MAKRDYYEVLGVSKNASEDEIKKAYRKLAIKYHPDRNPDDPEAEAKFKEAAEAYDVLHDPQKRQQYDQFGFDAPGGGFGGGGPFGGGGGFSMDDIFSMFGDVFGGHGGGFGGFGGGGHQAPKYRGSDLRLKVRLSLQEVATGVTKKFKVRKDIPCEHCHGTGAEEGSGTETCQNCHGSGVEIRTQQSIFGMMQTQTTCHVCNGEGTIIKNKCTHCHGEGVVKGEEVVEINIPAGVAEGMVVNVPGKGNAGRHNGVAGNIQVYIEEEPNDTFIRDGQNVIYNLLLDFPTAALGGQVDIPTIDGSNVKIKIEPGTQPGKTLRLRGKGLPAVQGYGSGTGDLVVHISIYVPKELNKEEKKIIEDLRQSENFRGDNSTKRSIFENFKKLFS
>CP022041.2|ASE18145.1|286398_287691_-|bifunctional-folylpolyglutamate-synthase/dihydrofolate-synthase
MTYQETVEYLFNSTPVFEHVGASAYKEGLETTKALDEHFGHPHTHFLSIHVAGTNGKGSCSHTLAAILQAEGYKVGLYTSPHLVDFRERIRVNGKMISEQEVIDFVEQERNFFEPLHPSFFELTTALAFKHFAEQKVDIAIIEVGLGGRLDCTNIITPILSIITNISLDHTQFLGNTLGAIAAEKAGIIKHRVPVVIGESVPETQIVFKAKAQKEDALIVFAEDIPAILSSRPNPDGGIAYQTRFFGDIVGELGGSYQEKNANTVLTAVMQLYNKGVIKNAESIAKGFANVCELTGLMGRWQKLQANPLVICDTGHNVGGWTYLSQQIKRQQCKQKRIVFGMVDDKDLHAVMSMLPDDAIYYWTQPSTHRAFPAEKVAATADEYDLHGMVFPTVLDAYQAALHDAAQSDFIFVGGSSYVVADLLTSLQKK
>CP022041.2|ASE18144.1|285410_286022_-|hypothetical-protein
MTIQEQIKQRIDEAEPGTVFFVNDFAEFDNEYVSKLLSTMKGFGVLERLAKGIYYKPIVTNYGNVYPSAEKIVKLIAEHENAEILPTGEYALNALGLSTQVPMKAIYLTTGSPRTITIGNKKIRLKHRTPSTYSYHSKLMPLLVLALKAKGQSNITSADTNRIEKLISDSTEKQQIKTDLATAPVWVRKYIKPIIEKYEHLAR
>CP022041.2|ASE18143.1|284374_285430_-|nucleotidyl-transferase-AbiEii/AbiGii-toxin-family-protein
MSIWQDKTIEERIAIVQNTALRTNIEDLAIEKDWWVTITLKALFSTSFSEFLLFKGGTSLSKGKWENIDLRRFSEDIDISLSRSWFTETEEKQKLYPFAKCENNNQLKSLRKASREVIFERLSPELNEQLAKLGAKDFYVENVKSIIQDGVEIPIDTDRDPVVLNVVYPSILDETNEYIQPKVKIEISCMSMDEPFENRALTSLIYDTFNEVDNATQCFVPTVLPIRTFLEKALLLNEEYQKKSPRSERMSRHLYDLERLMDTYSETAINDSELYKSIIEHRKKFYHISSVDYDSDKRENIKIWPTGEIENLFRDDYKAMIESFIYNENPLTFDQLRERILLLEDKFRENT
>CP022041.2|ASE18142.1|283027_284158_-|leucine-rich-repeat-domain-containing-protein
MKQIYILLIALLMGLSANAETSGSCGPNLIWTLTGKGVLTISGKGKMYDYSNNNRAPWEGYGKVKRIKIGDGVTTIGDYAFYDCGMPTSVTIPNGVTKIGDYAFYNCTSLASVTIPNSVTTIGDYAFSHCIPLTSITIPNSVTKIGKYTFDYCSNLTSITIPNSVTEIGDYAFTYCLALTSVTIPNSVTKIGEYTFYECSHLTSVTIPNSVTEIGTSAFEDCRSLTSVTIPNSVTEIEEETFKNCYNLQKVNIGNSVKTIGVSAFENCTNITQISSEAVVPPTCESNAFFRIYKSECKLIVPKNSLDAYKQAPQWKDFLLIEESTTGITNTVYNNSGLADVYTIDGTKRLSKASTDEINALPKGVYIVNGKKIIIK
>CP022041.2|ASE18141.1|281468_282737_-|leucine-rich-repeat-domain-containing-protein
MKQIYILLIALLMGLSANAEESGTCGPNLKWHLTNDGVLTITGKGKMYDYSVPYNSAPWRYFGVKRIIVGDSVTRIGEYAFSDCSSLTSITIPNSVTTIKEYAFSNCSSLTSVTIPNSVTTIGDNAFNGCSSLTSVNIPNSVTTIGGWAFSDCSSITSVTIPNSVTTIREYTFDNCSSLTSVTIPNSVTTIGGWAFSGCGSLTSVTIPNSVTTIGGWAFSGCGSLTSVTIPNSVTTIGGWAFSICSSLPSVTIPNSVTTIGDNAFMGCSSLTSVTIPNSVTRIGSEAFSDCTNLQKVNIGNSVKTIGEFAFNKCTNITQISSEAVVPPTCESGVFFYVNTSKCKLIVPKNSLDAYKQAYQWEDFSLIEGSTTGITNTVNNKAGLVDVYTIDGAKRLSKASTDEINALPKGVYIVNGKKIIIK
>CP022041.2|ASE18153.1|298813_300037_-|MFS-transporter
MMKQKTNYLFPLAIIGLFFFSIGFALGINSYLMPVLEKSMHISGAASSLLLAATFIPFLLFGIPATHCIKAIGYKRTMALSFAIFAAAFGLFILAAKQNSLTWFLIASFVSGAANAVLQASVNPYVTILGPMDSAARRISCMGISNKLAWPVTTLFITLVIGKGIGDTQLTDLYMPFTIIIGIFLLLGVIALMAPLPDVKAAGEDESECGDEAAVSSYADGKTSILQFPHLLLGCLALFLYVGVETISLATATGYAQSLGLEGDNYGFIPSVGMIVGYICGVIFIPRYLSQAAAMRICAIIALVGSVAVAVVPDPVISVYCIFLMALGCSLMWPALWPLAMADLGKFTKSGASLLTMAIAGGAVMPWLRGVVQDCTSFQTSYWVSVPCFLFILYYGLAGYKIRTKKE
>CP022041.2|ASE18154.2|300385_303865_-|beta-galactosidase
MWTQSIANPNQQIYITKKGSGYKLSAVSARNGQTYYVTFGSISSVDGYYCGYENSEASAATLQFKEVPAVVIPEGADWENAKVYERNKERAHATYMPYPSTKAMKADGQRYDKPWLDPTGANYLSLNGTWKLRWSEGAKPVLLGKDDFWGDGVSTEGSAWNDITVPSCLEMNGYGLPMYVNVDYPFEDQQPYVRMKAGLKNSVGSYRRDFTLPAGWENKRVFLHFDGIYSAAYVYVNGNEVGYTEGANNVSEFDITKYLRTGKNNVAVQVIRWSDGSYLEGQDMWHMSGIHRDVYLVATPKTYLADHYIKATVTPGSTTVATGSAATSVDLTVCNRDKTAAKKTVTVTLFDPSGKEVKKLKSDFVFAAGDSLKTQTVDFGTLSNVKLWSAETPTLYTFTFSQSQDGKEEEAFSTKYGFRKIDLSKGYLEVNGRRTYLKGANTQDTDPLHGRSISTDLMLKDIAMMKQSNMNTVRTSHYPRHAKMMAMFDYYGLFVVDEADMELHKNWDGVKTIINNTDWTGAIVDRNVRNTLRDRNHPSVVFWSLGNESGSGLNIMAAYNAVKELDNRYIHYEGSTRDNAEGTDLHSVMYPAVDHSRGGTTGPVTSDANHPSTGKPYFMCEYAHAMGNAVGNLREYWEAMEGSLMGVGGCIWDWVDQSIYSYDAIKNNQLTKNGFPAYITGYDCPGPHQYNFVNNGLVNADRAWSAELDEVKRVYQWVGFNLNKDTHQVKLTNKYLDRNLNQFYLKWTLLADGKPVQDGIVKKLNCAAGGTETVDLKYNPTAFAGKELFLNIGLYTKEATNWCDRDYPVAEFQQQLAQRTEVLDKVDNTKADALHATKNSDGGYTYANGKQKVTFDGQGNITLWAYEGKDLFVQNEGPRFDRYRWIENDNPMEAYGNDPTDNGVKSQTATFQLSDDGKTATVNVTQNGNYGKATYKYTINANGTIDLASSFEAQGNGARRLGFSLNFPSDMSKVSYYARGPRASYIDRLDGEDFGIYETTVKDMYEPFAHPQSNGNRIGLRWLTLTNNEGNGVKVETSGDVAFSLTPWTEAELRTARHEWELPTSNRVVAHFDAIQQGLGNKSCGPGPLSKYEIQKGKTYSNIVRFIPFSETADDTANGISAVVNSATTMAQVYDLSGRRLPEPPAKGFYIQSGKVHAN
>CP022041.2|ASE18155.1|304286_307778_-|hypothetical-protein
MNICKRLCAAFLLSVVCVGQVFAQGYPRISTKGNEHWYYVKYLRSNNVLEDKGEKQKCLTAVPQVMNGGRQLWKVVAAENFGRNKKYQLVSKSGRTLYVNGTNPYSSRFMAATKATDITSFHIFQSMNTSFGTGAFELAPDSTNSHAMNQVGEIRAGQEIGLWDKGDINNVLTFVSKDDMEFPYYMPVISTAANPVYYYIQFQTGNWLLSAKGDKATCQTASLHNGNLDDMLWRVSEKDGKYSFVSKSGKILYISDSYVNAAKAHNVKDTLFTMVESNNSLGGFEIGKSTTGRNFFNMFQGAGEGRLISFWDLGDGGNVVRFVPAEALVPVSGITTFNPANKYTLWYTKPATNWMTSCLPIGNGQFGATLMGDVAIDDVQFNDKTLWSGKLGGLTSTAAYGYYLNFGNLYIRSRGMSKVTDYVRYLDINDAVAGVKYTMDGVAYSRTYFASNPDSCVVVRYTASQNGKINTTLTLKNQNGRNVSYTVDNNNQATITFDGQVARQDDHGATTPESYYCAARIVTDGGTITKNAKGIIEVNGANSMTVYLRGLTDFDPDAPTYVSGANLLAGRAAATVNDAQNKGYDALLAAHKADYKSLFDRCQLTLSDVKNNIPTPQLISSYRDNQHDNLFLEELYFNYGRYLLISSSRGVSLPANLQGIWNDNNTPAWHSDIHANINVQMNYWPAEPTNLSELHRPFLDYIYREACVKPTWRRFAQDMGHVNTGWTLPTENNIYGSGTTFANTYTVANAWYCQHLWQHYTYTMDKDFLRAKAFPAMKSAVDYWFKKLVKAADGTYECPNEWSPEHGPTENATAHSQQLVWDLFNNTRKAIKVLGDDVVSKAFRDSLATYFAKLDDGCHTEVNPADGQTYLREWKYSSQFNNPSKIGVNEYKAHRHISHLMGLYPCTQISEDADKTVFEAARQSLIARGDGHGTGWSLGHKINLNARAYEGQHCHNLIKRALQQTWDTGTNEAAGGIYENLWDAHAPYQIDGNFGYTAGVAEMLLQSHNDKLVILPALPTTFWQKGSVKGLKAVGNFTVDIDWAAAKATKVQIVSNMGTTCIVKYTNVAKDYKVTTADGKTVKAKRINDDEISFPTVKGGVYVIVSKTADAIAAIQKAQDGNIASVDYYSLNGTKTSQSQSRGVYIKQMKYSNGTTSTTKVIN
>CP022041.2|ASE18156.1|308639_309038_+|pilus-assembly-protein-HicB
MKKVTIIVEQASDGSYWCRTAEDIAGIGLNSCGDTVEQAKQDLIDCYQEAKEDLEEQGKTMPVVEFVYKYDLQSFFNYFSFLNVTEIAKRAGINPSLMRQYNSGIKNAGEKTYERLAACLDGIKAELQAASF
>CP022041.2|ASE18157.1|309456_311157_-|hypothetical-protein
MKKLFLFTLLCVITMTTQAQTNLSDYLTKRMPKRETRAVWLTTLASLDWPKNYARSEESIKLQKQELIDILDKYQKANINTVLLQARVRAATIYPSDIEPWDQCITGVEGRAPGYGYDPLSFAVEECHKRGMEIHAWIATIPVGAKNSLGCRTLMKKGFRIRNFSTGSYLDPADPSVAPYLASVCGEIVRKYDVDGINLDYIRYPDGWPRPSYRDGDTPDQRRSNITAIVRAIHDEVKAIKPWVKMSCSPIGKHADLSRYSSKNFNAHDRVSQEAQEWMRLGLMDQLYPMQYFRGDNYYPFVADWVENAYKREIVTGLGTYFLDPREGNWTLGDLTRQMYVSRDLGVGHAHFRSYFLTANKQGVYDFEKQFNATLSLPHKMQGVVSTAAMPYAVNSSLVERREDKSVILRWKAVTPYYNIYASYTYPVDTEDARNLLFARYTGQTLQLKNVNPNLYFAVRGMDRYGLETPALQENMKSTSLSKSPATLLANDGNTLTLPAAAKLTDADRYVILSLQGVILRIVNAKSVRNNQLYIGSLSDGMYSLKVYNHKKKSFTLGAFMVRRGS
>CP022041.2|ASE18158.1|312099_312531_-|NUDIX-hydrolase
MYTYNYPHPAVTADCLVFTRTDEGMKLLLIQRKNEPCKGKWAFPGGFMDIDETTIDAARRELKEETGLVVGELHRVGIFDAVDRDPRERIITVAYYTILDKPAEVSGLDDAAQAKWFSLTELPDLAFDHKEILQEAERVLGDG
>CP022041.2|ASE18895.1|312547_312760_-|DUF3791-domain-containing-protein
MDQKTLEFVTYCIGKLSVMLKLPQQEVYRRLKTSGILDEYIVPSYDVLHTFGSRYLMEDLTEYMKEKGVL
>CP022041.2|ASE18159.1|312939_313752_+|GSCFA-family-protein
MEFRTIVNIPRPTFELEPCERILFVGSCFADNIGKRFEEEKFRAMVNPFGVMYNPVSVLHTVKKVANHTFDTAVFTLGTNHVYVERATGEIVDNCQKRPQREFEERELTVEECADALREAITLLRQANPKVNVIITVSPIRYAKYGYHGSQLSKAVLLLATDKVIKEEGERIYYFPAYEIVNDELRDYRFYKADMLHPNEQAVEYIWEQLVATCFSAEAKQFLEEWRPIKEALAHRPFHPEAAAYQDFIKKTKEKAKMLELKYPNIELNL
>CP022041.2|ASE18896.1|313763_314195_+|transcriptional-repressor
MNDKQIEALLKAHGIRLTANRILIARTLSGLDNPASIKELEAKIQTIDKSNIFRTLSLFKQQHLVHQMEDGNDIVRYELCLSDDDEEDEDMHVHFYCERCHRTYCLNDIHIPQVELPAGYEQSSINYMIKGVCPKCAHRYYIK
>CP022041.2|ASE18160.1|314278_316759_+|bifunctional-UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine-ligase/alanine-racemase
MNYTIEKVTTLIGARRYGDKDANISFVLTDSRSLCFPEETLFFALKTERNDGQNYIPELYARGVRNFVVEVVPEDWATRYPDSNFLKVVGSLEALQRLAERHRDEYLIPIVGITGSNGKTMVKEWLYQLLSPQMVVTRSPRSYNSQIGVPLSVLLLNENTQVGVFEAGISQPGEMMALRDIIQPTIGVFTTLGTAHQENFPSLEAKCHEKIKLFHDTEAIVYSADNEVMAQCLSQYDYKGQKLDWSVKNTEAAFYIKAIEKKDIETTVSYVWKGQTEGQYKLPFIDDASVENSITCAVVSLHLGLTPATISERMAQLEPVAMRLEVKEGQHGCTLINDSYNSDFNSLDIALDFMNRRPDHKGRRRTLILSDILQSGDTDKDLYNKVAFLCEKRGVEKFIGIGEGLLAQRSAFKHLGEKHFFATVNSFIHSDVFANLHDEVILLKGARQFGFDRLTELLVKKVHETVLEVNLNAVVDNLNWYRSFLKPTTKLVCMIKADAYGAGAVEIAKTLQDHRVDYLAVAVADEGVTLRKNGITSNIMIMNPEMTSFKTLFDYDLEPEVYSFRLMDALVKAAQKEGITGFPVHIKLDTGMHRLGFDPQKDMDELIKRLKQQNAIIPRSVFSHFVGSDADNFDEFSAHQFALFDEGSKKLQAAFSHKIIRHMDNSSGIEHFPERQMDMCRLGLGLYGINPRTNKTINNISTLKTTILQLRNVPAGDTVGYSRKGTIDRDSVIAAIPIGYADGLNRHLGNRHCYCLVNGQKAEYVGNICMDVAMIDVTGIDCKEGDSVEIFGDHLPVTVLSDTLDTIPYEVLTTISNRVKRVYFQD

Crispr_ID: CP022041_3

• CRISPR_ID: CP022041_3
• CRISPR_location: 351616-351726
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_3

Consensus_repeat	Method
AACTACGAATTTCACTAATTACGCTAA	CRISPRCasFinder

spacers of CP022041_3

>3.1|351643|57|CP022041|CRISPRCasFinder
ACTTATTGCTATATAATTCGTGTCATTCGCGTAATTCGCAGTCAACTTTTTGATTAG

CRISPR arrays and Neighbor proteins around CP022041_3

CRISPR arrays

The CRISPR arrays of CP022041_3

>merge|CP022041|3|351616-351726|CRISPRCasFinder
AACTACGAATTTCACTAATTACGCTAAACTTATTGCTATATAATTCGTGTCATTCGCGTAATTCGCAGTCAACTTTTTGATTAGAACTACGAATTTCGCTAATTACGCTAA

>CP022041|3|3|351616-351726|CRISPRCasFinder
AACTACGAATTTCACTAATTACGCTAA	ACTTATTGCTATATAATTCGTGTCATTCGCGTAATTCGCAGTCAACTTTTTGATTAG
AACTACGAATTTCGCTAATTACGCTAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18174.1|332507_336281_-|T9SS-C-terminal-target-domain-containing-protein	unknown	unknown	gnl|CDD|227068
CP022041.2|ASE18170.1|329738_330131_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18169.1|329296_329719_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18180.1|354111_355203_-|endoglycosidase	unknown	unknown	gnl|CDD|374390
CP022041.2|ASE18187.1|363759_365589_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18172.1|330792_331104_-|T9SS-C-terminal-target-domain-containing-protein	unknown	unknown	gnl|CDD|275036
CP022041.2|ASE18177.1|343775_345608_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl|CDD|372283
CP022041.2|ASE18186.1|363441_363636_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18173.1|331722_332238_-|hypothetical-protein	unknown	unknown	gnl|CDD|377578
CP022041.2|ASE18175.1|336481_340219_-|T9SS-C-terminal-target-domain-containing-protein	unknown	unknown	gnl|CDD|227068
CP022041.2|ASE18179.1|352934_354098_-|DUF1735-domain-containing-protein	unknown	unknown	gnl|CDD|378016
CP022041.2|ASE18181.1|355238_356789_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl|CDD|372283
CP022041.2|ASE18183.1|360588_360789_+|aminotransferase	unknown	unknown	unknown
CP022041.2|ASE18178.1|345764_349142_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
CP022041.2|ASE18185.1|362792_363044_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18897.1|351907_352915_-|DUF1735-domain-containing-protein	unknown	unknown	gnl|CDD|366285
CP022041.2|ASE18176.1|340646_343676_-|T9SS-C-terminal-target-domain-containing-protein	unknown	unknown	gnl|CDD|227068
CP022041.2|ASE18182.1|356820_359922_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
CP022041.2|ASE18184.1|360895_362800_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18171.1|330198_330747_-|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|224511

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18174.1|332507_336281_-|T9SS-C-terminal-target-domain-containing-protein	gnl|CDD|227068	COG4724, COG4724, Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism].	4.64381e-48
CP022041.2|ASE18897.1|351907_352915_-|DUF1735-domain-containing-protein	gnl|CDD|366285	pfam00754, F5_F8_type_C, F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.	1.61729e-09
CP022041.2|ASE18179.1|352934_354098_-|DUF1735-domain-containing-protein	gnl|CDD|378016	pfam08522, DUF1735, Domain of unknown function (DUF1735). This domain of unknown function is found in a number of bacterial proteins including acylhydrolases. The structure of this domain has a beta-sandwich fold.	4.23306e-23
CP022041.2|ASE18180.1|354111_355203_-|endoglycosidase	gnl|CDD|374390	pfam16141, DUF4849, Putative glycoside hydrolase Family 18, chitinase_18. This DUF is likely to be a form of glycosyl hydrolase from CAZy family 18, possibly chitinase 18. This would have the EC number of EC:3.2.1.14.	5.25885e-73
CP022041.2|ASE18172.1|330792_331104_-|T9SS-C-terminal-target-domain-containing-protein	gnl|CDD|275036	TIGR04183, hypothetical_protein, Por secretion system C-terminal sorting domain. Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber average twenty or more copies of a C-terminal domain, represented by this model, associated with sorting to the outer membrane and covalent modification.	0.000439819
CP022041.2|ASE18177.1|343775_345608_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl|CDD|372283	pfam12741, SusD-like, Susd and RagB outer membrane lipoprotein. This is a family of SusD-like proteins, one member of which, BT1043, is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologs in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	8.49259e-102
CP022041.2|ASE18173.1|331722_332238_-|hypothetical-protein	gnl|CDD|377578	pfam05962, HutD, HutD. HutD from Pseudomonas fluorescens SBW25 is a component of the histidine uptake and utilisation operon. HutD is operonic with the well characterized repressor protein HutC. Genetic analysis using transcriptional fusions (lacZ) and deletion mutants shows that hutD is necessary to maintain fitness in environments replete with histidine. Evidence outlined by Zhang & Rainey (2007) suggests that HutD functions as a governor that sets an upper bound on the level of hut operon transcription. The mechanistic basis is unknown, but in silico molecular docking studies based on the crystal structure of PA5104 (HutD from Pseudomonas aeruginosa) show that urocanate (the first breakdown product of histidine) docks with the active site of HutD.	5.10476e-20
CP022041.2|ASE18175.1|336481_340219_-|T9SS-C-terminal-target-domain-containing-protein	gnl|CDD|227068	COG4724, COG4724, Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism].	5.80848e-36
CP022041.2|ASE18181.1|355238_356789_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl|CDD|372283	pfam12741, SusD-like, Susd and RagB outer membrane lipoprotein. This is a family of SusD-like proteins, one member of which, BT1043, is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologs in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	0
CP022041.2|ASE18178.1|345764_349142_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
CP022041.2|ASE18176.1|340646_343676_-|T9SS-C-terminal-target-domain-containing-protein	gnl|CDD|227068	COG4724, COG4724, Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism].	3.66339e-33
CP022041.2|ASE18182.1|356820_359922_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
CP022041.2|ASE18171.1|330198_330747_-|RNA-polymerase-sigma-factor	gnl|CDD|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	3.7543e-34

Protein sequences

>CP022041.2|ASE18178.1|345764_349142_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MKIFKESKQKHLYFSAAFALSLALAPTGVYAGTNTSTAVQAVQQNGNHKVTGRVVDSTGEPLIGATILVEGTTNGTVTDIDGNYTLNTTANAKLVFSYIGYAAQTIPVGGKGTIDVTLKEEANTMNEVVVTAMGIMRKEKSLTYATQQVKAEDLMKVQDPNAANSLEGKVAGITITPSAGGAGGASKIVLRGNRSILGNSSPLIVVDGVPMSNGIRGQQGMGAEGFGSTGTSEGSDPLSLINPDDIESINVLKGANAAALYGSRAANGVVMITTKRGREGKVDINVTSNITFDSPLLTPKIQKTYGAAYDKTTGALSLNNWGGKLADRADNDLVVRTPLDERWVGYPEEQIGTDASGNPIMARRHNVYLRNRAGNDVDNFFRTGVTTNNSISLSGGTDIARTYVSVANSHATGMMRNNSYNRNSISFRQTYNFFKRLHIDASMNYTESKTKNRPGGGTVGNPLYHLYTAPQNIDMDYYRDHYMNAEGKWLSNPGSYYKLNGSNFAWAAGQRTTLTGPQQEWAYLSHPNNNPYWLINSGNSQQKESRLFGTLQANVDIYDGLTFQARVNYSQIRFKNHATRFATTFLPASMEDYGRLWDSDEKTTEFYTDYLLSYNKTFGDYSVSATAGYVGHTIKGESKGTDAVATYYDRLMRKLPTMVNYFETSAGGYGVTSTSKSSNWDRSYLFTAQLGWKETVYFDASYRRDWYRPFRYFKELGKIDTDNYGYFGVGANAIVSQLVKLPDWFNFLKYRVSYSSVGNSIPNKAYGAMSRNLQTGALSGNKLLDFSPVPEETGSFETGIESLFLNNRLSFDFTFYNTIVRHLYMELGSLGGNTELLNSAKVRNTGFETTVGYDFKFGKDLRWRTSYNLSYNDNKILETGYDKDGTSRKYQQTVGEAKVIYQKGGAIGDIYAGDFMRDANGHIVLTAKGEPTFDKTGSNDRFLGNMNSKWQMGWTNTFNYKEFQLSFLINGRIGGKVLSLTESYLDYIGASERTEAARLSAERNNIVATNYGNVPGMELNDGSGRIVPIQSYYQALGASSNPSTYLYNGTNFRLRELSLGYTFRDLFGMNRNLTLSFIARNLFFIYKDAPTDPDVSLSTQNGLGAFESFNMPSSRSFGFSLKANF
>CP022041.2|ASE18177.1|343775_345608_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MKSKHIIVLMAMALPTLGLQSCLDYDNPGDEFNSTTKNVEKVTSRGDVDKIPFRQATDAAAADEALNAMQDLLDAGVGGQFSMRGGKNGENPGPHAYQYQYSLGVDNYAEYTVIPHTFFQYSKIRLASSYAIDQKCYGGAWGSFTEMKTSLVPILNNEKVNAVPELKAAYLTLFNQQAVEVADVYGPMPYRELKTNLQVGPYTYNKVEDVYNDAVANLDTAIACFHYFDQKPAAYKQKIKSAFVDRFVVMTDGGAADGTLKAWARYANSLKLRIAMHMVKSDPVRAQKLAEEAVADGVIENEAQSVSIRPGVMGFSHPLPGVESWGDARMSATMEITLKTFNHPWLKYLFKKNDNVIKNNKTGETTPADSRICGIRTGTHPGEGQGYDENQYIAFSKLNEQYFNSAPLYLMKYAEVCFLRAEGALRGWNMGGSAQHFYEEGIRHGNCEDPEMKSMDGESPNGQQNVNWYDSWIDTYMAQENPVAYVYKDPTGDTPDAASPIHVGVKWNDSDSQETKLEKIITQKYLATYPNGFEAWVDLRRTGFPRMLPVLNIDEADGSLVPGDIMRRLPFPGTSDIATKQDVDNTGIPALGGPDKMATRLFWDKTTSNF
>CP022041.2|ASE18176.1|340646_343676_-|T9SS-C-terminal-target-domain-containing-protein
MNKKSTLSAWIIAAMMAMAPAGVTAQTYSSTASTQVFDLSKLGDQTLLEHFAELLDNGKKYPTDADLTAWGIKDEVEFIRSHVRKRAIESRADRLLQDTYENRNLFMNIPGGAGKNLGGYPSKTFANDNFSMWNYTNLFGAWNYGLFQAPGSWADAAHRNGTSIFAGIKFFDHTTGGAANSWASFIMKRNTDGSFRYTHPIINCMRFLGFDGINYNWESTNKYQDADNIAFHKELYKIAKSEGFNDFKIMYYTTSSRLTSYNSSYMWGQDKDNRICEVMLNYDNSDFSWSMGESVREAERTMGSADGLYAGVWIVSMDRRWNSLNNQDAKRCGICLWGEHAESRFWSYNTGGDAMSRMSNYQEYLERAFSGGNRNPLYRPEVSNRGNNVEAQGTTPPLARFAGLASWIPERTAISGNLPFATHFNTGNGERYNYKGKKTAGSWYNMSSQDVVPTYRWMVVKPETEVASTDVQPSFTNEDAYTGGAALRLKGVNNATATDVVLFKTNLTPSKGKVVAKVAIKTGKEGNNDSKLSLIVRVNGAWKAYALGNTENANWTEKKVELNDITAGQKIERIGLRVKDSDADYNVLVGKLELNDDVTATPANVKDLTVQVKEETKNSLSVKAVWGIDKDPGQNPTVYNDEANIDHFEILYKNGENGKVSEVGRTSQWATLVPNIQFTSVDDKPFIGVRSVSTDLKTYSKTKWIAVPRAQQSELPEAQEEGYGTVELDNAAAGAETARKIRYVQKFQTEGGSKNIDYTANGPAGNETNYVDATSQELEVAQGATVKVKIKGYEATQMKDQSNDDLRYCMGKAWMDFNGDKQFNPENLSENPNEGECVVFFGQVRKGVPAQVQQLNEYTFKVPEDAKPGQSRLRLVFCDAWFQGGLTPTGKFNKGFAIDFKVTITGSNAARGAKADTHDKGVADEPELLEGGSTNIISANVGGASQLTVVGGKVVFENVERAWVFSTDGQTVKSLVNPKSFNTNELPAGVYLVKMQNNNVIRTQKITIK
>CP022041.2|ASE18175.1|336481_340219_-|T9SS-C-terminal-target-domain-containing-protein
MRRINLLLFGCCLIPSTLMAQELKSNYIQWGFESQQFPGKLQSWSKSNPKINDDDNFFISRVKPKARFRYEGTQVRTDLTETNDKKLLAWLPWNVPSKNALPDGVFDSEVFSMWPYVTHWGDWNCGLGRIPAALLDAAHKNGVPVSSVAGIPYGGLSGAWSSALEQLATTDVQKAAAYMNYFGYDGLGYNSEYSEYFGGGRITRKLRDFHVDLNKAIRPTNPIYENIWYDGTNDKGRISFDHGLNEYNKSIFGAKGSEAANLFFNYNWNSSTLLQNTVEMAEEIERNPLDIYAGINMQGGEPRTGSRWTLLKNYPISIGLWGAHSQNMFFESRGEKGSDPETQQRTYMLRTERWFSSGSRNPVNSLQINNSLNYNADNTDFAGMSAMMTARSSMSWDLTQEPLITYFNLGNGKFFNYGGVRKNDRPWANVGVQDYLPTWRWWFASKLLGRTAVDVPATGLDAEFVWDDAYMGGSTVRVHGSTPKEYLHLFKTKYALKTGDVITFRYKVKGGKADASLVFATEDNVNAEKAYPVLTTADEADEDKWVEKTITVDGTLNGKTLALVALKMENAADLNLYLGEFSIVRGSFDAPAQPIDVKTTLLHAAKNGVDAKIIFNMPNTKGQGEPCYNTDVKTSLFKLWAKQEGKDPILMGVTTSWAGMFYSVPVDLKGQGKVKFGVSAVSLDMKKESAIAWGEDHEIFNSYEYSDEIKADKSVIKPNEAFTIAYVDPRHEAGNWKIEQNGATVASSNNANEIKVENGLSQTGFYDLVLTGAVNENGARVNKEVRYANYIQITSDAVGAVPHINKLTANNSETSIEVVANSEVTMKYEGKKADGSGSRGIKTLEKPVGVKVSELGLTSNNQAWTLAFWVKFNGFTGNTQIIDMRDPGTGWPQNNWGTMWTTYDPNTGVYEVTLREKNAGGAKEYKQRWEVDFVPGAWTHFVLAMEGNGTTTKPMVYINGKAAKAHNWEYDGHKGDGINPDGFANNAWWDNNVLGISLGRAGAAAINGTVDDVKFFNKALTAAEAAHTMMSTDANEAGLKAYWDFEADADASHYFTSKVGNAKLAHGELKAGEGEGVTTLVPDAPTYDAGSAFVSGTFQVKTTAEWTAKKATIVSQDGTDMAGTAKLKYAKAGDYEVTLTLKNAHGSDTRTFQVIKVKADPTGINGTETADMKVYAIDRDVLFDVETPGNYLVQVFSTNGQMVASKAVSVNGAESVRLHLGAQGVYVVNVKKDGKTLRTVKFICK
>CP022041.2|ASE18174.1|332507_336281_-|T9SS-C-terminal-target-domain-containing-protein
MKRITLFASLALASCLTVSAQRTPTHPLDIQDAKFENLPNYLEAWLKGEMKQPQGVSEIDDQFFISRVRPLERIKDGDYQVRQGVKRDRKMCLWTPLDDPTAQWKALPRYCFEGDNFSLWSYIDIHGNWTSPWIRSTAGLTDVAHKNGVSVGCVMSIGYGAYIYLNQWRPDTYSKTLYKLTKKEGGKFVYAAPLVRMMKYYGVNGIGFNSEFRTSSDVMATLTDFFVACHKEAEKINWKFEVHWYDGTGDDGSIHFDGGLGSHNQNIFGDKDHIATDMLFANYNWGPSHLRGSVSTAQRLGRSSFDYYAGFDIQGRGLRQPSWSALLNNDISIGFWGAHSQSLIHQSATDNGTSDIAIQKTYLKKQELMFSGGYNNPGLLPAINTDCNLANASLKNFHGLATFLSAKSTIQQVPFVSRFNLGNGLSFRKDGKVTFNHKWYNLNTQDYMPTWRWWITDGADQVNTGNINSLAKAELTFDDAYWGGSCLSISGQTDFSRVKLFKTMLEVQPDYEFSVTYKTIAGKDTHAKFFVALKDHVTEYKEVALPAVEAEGKWNTFTVKASELGLAAGDKVAMMGLVVENTPANYELRVGEMALRDNAKDFATATPTIKKVEILRGRYNACDFKMQYASKEESGWEKTYNDEVGTWYYEIYFQQKDQPQQLLTATTSWAAYVVDAPMVSGADKRDCRFGVRAVSPDGKKGSEIVWSDYQTVAYDQPLSDVVADRPVIKPNEEFTLKYLDEMVPAAQAWKLQDAVTGQVVAQGESGTSAKFTVAKEGTYDLVVVDNNGKESVVRGKVKITPEATGAVPQITDITADKTTEKVGQNVTYTYEGRLGEGKASRGLEITDPKMFRIPGDVQQGKSYSYALWFKADKFNHDKQGTNLINKNSIYDSWPHNNWGDLWVTIRPEWQGSRALHAANEISFNTMGWTAHDNPYEDVMTTGYSVTPGVWNHIVVTHTDGNIQKIYFNGRQVASHSFAASSRREDYGDRRINASKVADIFIGGGGVYKSGFNGIIDEVQVWSKPLSDDEVLRAMKGYKEGEVPADLKAYFTFEDVDGMKFKNIGSAGRTYDGSVVVVSGSGGENTSSAAYVDQQPNNNVLGFPGVVGTYEIKTVPTWALGDGQISSSADKTAVVTYAAPGKKNVTLKLKNGWGEAEKTVEEIVEITSEANAIDAVDAQLGFSVYPNPFVESVNMRFAENGRYTINVLGTTGALLQSNSFEAAQGQVVNVAITGTKGMYLVQVLKNGKVYKTVKVIKR
>CP022041.2|ASE18173.1|331722_332238_-|hypothetical-protein
MTTLPQSSYKTTTWKGGVTRQIFISPADGDLSARQFDVRISSAIIDDVQSVFSDFSGFTRYILPLEGEITLIKEGRRIVLSHNDLYEFEGDEKVSSENTQGAVDFNIIVRHGISVEVGIVEDAAFTDSRRTIVFALEDCCIEGKTVRKHDTALLDEPFSLKGKAVIARFME
>CP022041.2|ASE18172.1|330792_331104_-|T9SS-C-terminal-target-domain-containing-protein
MIKNIFTPFLFTLLLSVGFTAPVQARAAIDLIDLDVQTISISVVGNVLHVVGAENEQLAIYNVTGVRVMSVKVDGDDKHYTLNLPKGCYIVKVGNVVRKVSIR
>CP022041.2|ASE18171.1|330198_330747_-|RNA-polymerase-sigma-factor
MTPLDEAEVIRLLASFEGRQKVFPVIVDQYSQSLYWKIRSIVLTHEDADDVLQNTFLKAWKSLPTFQGKAKLSTWLYRIAINESLDFLRRQKAATLSSADADLSVANRLLADDYFDGDKSQALLQEAIATLPDVQRTVFTLRYYDEMKYSDISEILGTSEGSLKASYHIAVQKITDYVKRYE
>CP022041.2|ASE18170.1|329738_330131_-|hypothetical-protein
MESTNHLQKEYGTQRPFTVPENYFSELSSRVMAQIPAEEQKEAVVAVKPHRTMVHYLRPLAAAAMTIGVVLVGFLAYHEFDGEQGKHALAEGHLAQGAHETSASSEDEFDKAADYFMIDESDMYAYLASE
>CP022041.2|ASE18169.1|329296_329719_-|hypothetical-protein
MKHKRIILLFCIFFSVSLLHAQGKFDFNRIKAESHNFITKEAGLSGQEAARLFPVYDEMRGKQRVYFDKLRAIFSAKPSSEREASKTIEQADAYEIQLKQIEQRYHKEMLKVLPATKLLRVLEAERRFHRQTFRKMAGRR
>CP022041.2|ASE18897.1|351907_352915_-|DUF1735-domain-containing-protein
MKIKVFKSVLAASLVAATLASCQSEPEVGSTLYPTAEENYSAKAYLYTGTSDGNKLLLAGEKSASTVTLANDSAKFYVRLSSPAEKDVTVTLAATSDGVEANSSEEVMSTDAISLSKTSVTFAKGQQVSEPIVVKLVNGDALKNLAMLKNGVTSVVIKSVDGAETAKTNTKVLVTTNFTFNNINASGTLNADKQIALNEYQMSTTLSSSNAAKLNDGDNNTYVYSYTYYEPEFTMAFNSTKELIGVGILCNYTSYGYGVKKVAVATSLDGKTWTNMGTATAASTYDDDTPFPIVFNTPVTCKFVKLTILQSFDESENPRFLIGEIGAYEYLDWNL
>CP022041.2|ASE18179.1|352934_354098_-|DUF1735-domain-containing-protein
MMKYNISKLFIGAVAMASLTLLASCENAEYSPLSNQAYIAQTNTNGNSSQNITIGTSAVTSSVNVRLSDLATQDYTFEVVSDTTALAEYNQRNETSYKPLPASLYSLSSNEVKIEKGKSVSSDVTLTINPLTQALKDSGQKYAVALRLKSKDGKYDVLNSGSSMVYILDQVVYQAVPIINATHNIHFAMRQTYDLSQWTVEMNVNISKLGKGLGELNNQTLFGAWGNDGGEIYTRFGDAPIEGNRLQIKTQGTQMNSKQLFNENQWYHLAFVCTGTKLYLYVNGALDNSMDLPGKATNLSNRINFGNTDYLKANVKVSELRFWTVARTQAQIANNMYACDAKSTGLEAYWKLNEGQGDTFKDATDHGNTGKCVAVPTWEQNVRIDGK
>CP022041.2|ASE18180.1|354111_355203_-|endoglycosidase
MKNLIKIFLLSACAATAFTACSDWTETEAKDGADLTHTNKSEAYYAQLRDYKKTDHSVAFGWFGNWTGTGVTHENSLAGLPDSTDFVSLWGNWKNPTEAMLKDLRFVQKTKGTKVLISCLVFDIGDQITPTNTDSTLTWKEWRHKFWGWGNDEASQIAATEKYANAICDTIAKYGYDGFDLDAEPSYAQPFQTDKELWQNAKVMEAFVKTMGKRIGPKSGTDKMFVIDGEPDAMAAQYGEYFNYFILQAYSSSGNSDLNSRFTAQATHFQQYLTPEQVANKLIVCENFENYAGKGGVSFRLDNGTTLPSLLGMAYWNPVYNGVTYRKGGVGTYHMEYEYTVSGQTGNYPFLRKAIQIMNPSIQ
>CP022041.2|ASE18181.1|355238_356789_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MKKINIYKAVTACTFASVLLCSMSSCTDGFQEANRPGTGASLEDLSRDNYQTSSFLVQMENEAFPEQENAYQMNEDLIGNYLGRYMTYANNGFAEKNFARLNAPNGWVRYPFKDSMTKTVSAFKAIDNVTKGEGPVYAWALILRAQSFMRLTDMYGPLPIGADATDGNAYSSQEDVYKSIIADLNKATDVIKPLVASNPNVTIAEELDKVYQGKMAKWLKYANSLKLRIAIRIRYVEPTLAKQLGEQAVQDGVITSNDDNCAIAYTPNGQYKTSVEWGDSRACADLESFLTGYNDPRLTKFFTPVEGGIRSVIGCRAAAKIGNKTTAGKAYSAANIKIDSKGVWLTASEMAFCRAEGALAGWSNMGGSAKDLYEEGVKLSFEQWGAGSATAYLADNTSTEKNYVDPISEYGGDVSAVSNITIKWDDSATDEQKMERLITQKWIAMFPNGQEGWSEIRRTGYPKVFPLAQSTDYSIQVANRIPFDIDEATNNKANYIKAVQLLKGNDDYATKMWWQR
>CP022041.2|ASE18182.1|356820_359922_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MRKGKILPVSVFLSCCSLTAFASSHVTSADNFGKNVVVAATKANTAKVLGTQQSSGDVKVTGTIVDNAGDPVIGATIRVKDSQHGTTTDLDGKFEIMTHKGATLIVSYIGMNTEEVKVSGDAPLNITLKAEAHQIEEVVVTALGIKRSEKALSYNVQKVGGENLTTVKNPNFMNSLSGKVAGVNINASSAGMGGAARVVMRGPKSITRSNQALYVIDGVPINNTSQGEISGGAFSSQPGSEGIADINPEDIESISVLSGPAAAALYGSAAAQGVIMITTKKGKEGKVSVTVSNSTQFANPFVMPEFQNSYVNRAGDVKSWGAKTPSVYGDYEPKDFFNTGTNVQNNVALTAGTDKNQTYISVGTTNAKGIIPNNSYDRYNFAFRNTTTFLHDKMTFDFNFNYIKEHDKNLTAQGQYFNPLTAVYLFPRGESFDAVRTYELYDVTRGINVQNWNFGDALSMQNPYWVANRMVRSNNRSRYMISASLKYKIFDWMDVVGRLRWDDAGTKQEDKRYASTTNLFAHSKYGFYGYDKVNDRSLYGDLMFNINKTLNDFSVSANLGGSFTRNKYNVTGFQGGLKAPSNLFTPNAIDYGSATADNRPIFTDHAHKINSLFANVELGWRSMLFMTVTGRNDWDSALDGTDNVSFFYPSVGMSAVISQMATLPSWISYMKVRGSWASVGSAISPNITSPWRYQYNPASGTYSTVTYKFPSNFRPERTNSWEAGLTSRFFNNALTLDVTVYQSNTRNQTFLRPITGSQGFSSEYVQTGNVRNRGIELSLGYGHTWGDFAWNTNFTYSANRNKIVELLDDPNEVINQGGLNGANIILKKGGTMGDLYMTSDFKRDAEGNVAIKDGNVSQVNLTNPSYRGSVLPKGNIGFSNDFSWKGFNFGFVVTARFGGIVMSQTQALMDAYGVSKASADARDKGGIAVNNGLVSAENYYAVVGGENPIWSEYIYSATNARIQEAHLAYTFPRRMLGGMELTLGLTANNLLMLYNKAPFDPEATASTGTYYQGFDYLMQPSLRTLGFNVKLKF
>CP022041.2|ASE18183.1|360588_360789_+|aminotransferase
MKKIYLEPETKVYEQKVEGHLLAGTGVEGSTTDPKQGGDPTSTSTTTIPNPFNSEAKEKSKWYTKE
>CP022041.2|ASE18184.1|360895_362800_+|hypothetical-protein
MEKLSKFAIVLCGTMAISLAACQTDELSDNTAGENTPKVYHVTVSADAAQGTGASTRALAVDPANGKRLISEWLVNDELAAFVNGDEGKQNNYFVLTTDRGGKSAKFIGDIAAAGRSMSTNDNISFLYPAVALKGANKTITPVERREESVAVGTVSKIISYVPSAKAQKYVSLNLSRQDGTAASLGSRFDYQCKSSHPQKVESDKLDIKIGKLQRLVSFWGLRFTDENNNKLSNIDSIYVSNIKASGILNITDNTFASDDKYEANKSIAVIPAKGTKFTSANNQYTYIALLPGNYTNVHIMVYSKGKMYEQEYANINFTADNVYHTDILHMTPVGPKPWVEVQGVKWATGNFIHYGPANGGYWGIAPAQWWISQRAVTLNNRRKVTNDKAGNTTSQFADFPTQKVEDVDLFRYGHIKEALDLRSSLLFRNSVAGKKLYYPASAGTYTDWDINGTGATRGDIAWYYTKDKHQHYRMPTGDEMKKLYTEARAIPAYCYTDKGTKVYGAYFTTSTSGGYHEFPAKRFVKSIDSYTNVTALIQANKGLFLPYTGLRDPGAVGMKMRDLSGDGNAYGQYMTTDDSKWNDRSADFFFGAAEWNWAEHPKTQAKAIRPVWDSGDNTLDSDYLNLRNSLGIK
>CP022041.2|ASE18185.1|362792_363044_-|hypothetical-protein
MLRVQKGVNKGLKGHLLQVKRALVASRLVVFIKLVCEKKADKGGRWFGFKYGDCEKENEFGNHAEPIIIKVYLKKTESSGTFT
>CP022041.2|ASE18186.1|363441_363636_+|hypothetical-protein
MRKSELMALETIATGMKVAYQKPLCAILSVEAESVICSGSVTGETENKNVSEDPSDAWYTGQDS
>CP022041.2|ASE18187.1|363759_365589_+|hypothetical-protein
MKKRILLPALCMAISIFTASCSSDDIESPEAKEQMVTLTVSAGTEDDAAATRAVLSEADAAKSPWKWEQGDKILLVSGNGSQKTVSTLSLKSMKRGGLGADFEGQVPASSVTNGSTYRFFYVGKTSDGRSDRSVDASTGSINIDLTQQTGNLADLKRNCVLTGEGKVVVSGNKATTEGSIKLANVFAVAHFAVTANNNTALTKIGLRGKGVYASANVDLSTGAVTGISEIGTEVDPEENIFFPDGKTDFYVTFVPGTVAPAFDGYYAGSHSNTEAITSTPEARNYAADKSFVYLNGQKAKFSVSATQKVAITNGNMQYVMPIATYTSAMNTKTLSANTLIRWKNSVPLKLKGSLTIHKGYYRLAPEQWEMAMPKNKRTGGSYSYSTIKINGKEYVSPETYGYFDLPSWGTIDNPTVINNTFSIRGTGTETQYDFGNKLYVGSKKTRVMTSDEWAYLMPQNTNNSNNRIWIENGKKYAKWARCFIDENGDGKRGTNPAELRGYLIFPDDMTIDEARNAFTKTPTFGGGNAINNPTTYEKIKSSGAVFIPLSAYRSRNNRTLSVWGEHGNYSTSSYVNGSMVHIRITATSSIFNDRSDPNQGCMSRLVQNL

Crispr_ID: CP022041_4

• CRISPR_ID: CP022041_4
• CRISPR_location: 415025-415115
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_4

Consensus_repeat	Method
TGTGGCAAGAAATAGTAAACGGAAGCTAA	CRISPRCasFinder

spacers of CP022041_4

>4.1|415054|33|CP022041|CRISPRCasFinder
TAAGCCTTCTTTGCCTTAAAAAAACTCTTAGAT

CRISPR arrays and Neighbor proteins around CP022041_4

CRISPR arrays

The CRISPR arrays of CP022041_4

>merge|CP022041|4|415025-415115|CRISPRCasFinder
TGTGGCAAGAAATAGTAAACGGAAGCTAATAAGCCTTCTTTGCCTTAAAAAAACTCTTAGATTGTGGCAAGAAATAGTAAACGGAAACTAA

>CP022041|4|4|415025-415115|CRISPRCasFinder
TGTGGCAAGAAATAGTAAACGGAAGCTAA	TAAGCCTTCTTTGCCTTAAAAAAACTCTTAGAT
TGTGGCAAGAAATAGTAAACGGAAACTAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18217.1|409446_410670_+|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341157
CP022041.2|ASE18232.1|431479_432805_-|Na+/H+-antiporter-NhaA	unknown	unknown	gnl|CDD|377746
CP022041.2|ASE18228.1|426671_426869_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376540
CP022041.2|ASE18220.1|413917_414274_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18226.1|423743_425309_-|ATP-binding-protein	unknown	unknown	gnl|CDD|372641
CP022041.2|ASE18214.1|404165_405722_+|type-I-restriction-modification-system-subunit-M	unknown	unknown	gnl|CDD|211578
CP022041.2|ASE18212.1|400658_403502_+|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl|CDD|223683
CP022041.2|ASE18224.1|420531_421500_-|PD-(D/E)XK-motif-protein	unknown	unknown	gnl|CDD|379594
CP022041.2|ASE18223.1|419750_420530_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18215.1|405740_407849_+|DUF262-domain-containing-protein	unknown	unknown	gnl|CDD|377008
CP022041.2|ASE18221.1|415426_417289_+|DUF4268-domain-containing-protein	unknown	unknown	gnl|CDD|379461
CP022041.2|ASE18225.1|421517_423731_-|endonuclease	unknown	unknown	gnl|CDD|378453
CP022041.2|ASE18219.1|411927_412854_+|site-specific-integrase	unknown	unknown	gnl|CDD|271189
CP022041.2|ASE18211.1|400372_400618_+|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379188
CP022041.2|ASE18216.1|407855_409301_+|transcriptional-regulator	unknown	unknown	gnl|CDD|225420
CP022041.2|ASE18218.1|410662_411811_-|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341157
CP022041.2|ASE18231.1|429165_429687_+|DNA-binding-protein	unknown	unknown	gnl|CDD|375718
CP022041.2|ASE18213.1|403513_404164_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18227.1|425298_426660_-|restriction-endonuclease	unknown	unknown	gnl|CDD|365904
CP022041.2|ASE18230.1|428062_428548_+|peptidase-M15	unknown	unknown	gnl|CDD|311960

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18217.1|409446_410670_+|restriction-endonuclease-subunit-S	gnl|CDD|341157	cd17268, RMtype1_S_Ara36733I_TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.Ara36733I TRD1-CR1 AND S.Ara36733I TRD2-CR2. Actinomyces radicidentis S subunit (S.Ara36733I) recognizes 5'... CGAGNNNNNCTG ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	2.50802e-39
CP022041.2|ASE18232.1|431479_432805_-|Na+/H+-antiporter-NhaA	gnl|CDD|377746	pfam06965, Na_H_antiport_1, Na+/H+ antiporter 1. This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyze the exchange of H+ for Na+ in a manner that is highly dependent on the pH.	1.60018e-175
CP022041.2|ASE18228.1|426671_426869_-|XRE-family-transcriptional-regulator	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	1.75202e-05
CP022041.2|ASE18230.1|428062_428548_+|peptidase-M15	gnl|CDD|311960	pfam08291, Peptidase_M15_3, Peptidase M15.	5.14835e-17
CP022041.2|ASE18214.1|404165_405722_+|type-I-restriction-modification-system-subunit-M	gnl|CDD|211578	TIGR00497, hsdM, type I restriction system adenine methylase (hsdM). Function: methylation of specific adenine residues; required for both restriction and modification activities. The ECOR124/3 I enzyme recognizes 5'GAA(N7)RTCG. for E.coli see (J. Mol. Biol. 257: 960-969 (1996)). [DNA metabolism, Restriction/modification].	1.25866e-146
CP022041.2|ASE18212.1|400658_403502_+|type-I-restriction-endonuclease-subunit-R	gnl|CDD|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	5.89977e-163
CP022041.2|ASE18224.1|420531_421500_-|PD-(D/E)XK-motif-protein	gnl|CDD|379594	pfam14390, DUF4420, Putative PD-(D/E)XK family member, (DUF4420). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 310 and 334 amino acids in length. Advanced homology-detection methods supported with superfamily-wide domain architecture and horizontal gene transfer analyses have established this family to be a member of the PD-(D/E)XK superfamily.	5.07995e-15
CP022041.2|ASE18226.1|423743_425309_-|ATP-binding-protein	gnl|CDD|372641	pfam13589, HATPase_c_3, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	4.74878e-15
CP022041.2|ASE18215.1|405740_407849_+|DUF262-domain-containing-protein	gnl|CDD|377008	pfam03235, DUF262, Protein of unknown function DUF262.	2.13758e-27
CP022041.2|ASE18221.1|415426_417289_+|DUF4268-domain-containing-protein	gnl|CDD|379461	pfam14088, DUF4268, Domain of unknown function (DUF4268). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 151 and 387 amino acids in length.	6.9822e-19
CP022041.2|ASE18216.1|407855_409301_+|transcriptional-regulator	gnl|CDD|225420	COG2865, COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription].	4.57479e-72
CP022041.2|ASE18219.1|411927_412854_+|site-specific-integrase	gnl|CDD|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	6.24457e-37
CP022041.2|ASE18211.1|400372_400618_+|XRE-family-transcriptional-regulator	gnl|CDD|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	1.09571e-06
CP022041.2|ASE18225.1|421517_423731_-|endonuclease	gnl|CDD|378453	pfam10593, Z1, Z1 domain. This uncharacterized domain was identified by Iyer and colleagues. It is found associated with a helicase domain of superfamily type II.	1.07579e-21
CP022041.2|ASE18218.1|410662_411811_-|restriction-endonuclease-subunit-S	gnl|CDD|341157	cd17268, RMtype1_S_Ara36733I_TRD1-CR1_like, Type I restriction-modification system specificity (S) subunit Target Recognition Domain-ConseRved domain (TRD-CR), similar to S.Ara36733I TRD1-CR1 AND S.Ara36733I TRD2-CR2. Actinomyces radicidentis S subunit (S.Ara36733I) recognizes 5'... CGAGNNNNNCTG ... 3'. The restriction-modification (RM) system S subunit consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. It may also include TRD-CR-like sequence-recognition domains of various type II restriction enzymes and methyltransferases and type I DNA methyltransferases.	1.43477e-17
CP022041.2|ASE18231.1|429165_429687_+|DNA-binding-protein	gnl|CDD|375718	pfam18291, HU-HIG, HU domain fused to wHTH, Ig, or Glycine-rich motif. Rapidly-diverging family of HU domains predominantly observed in the bacteroidetes lineage with a predicted role in recognition and possible interception of the DNA of parasitic elements, a counter-conflict strategy preventing incorporation of these elements into the host genome.	3.90955e-27
CP022041.2|ASE18227.1|425298_426660_-|restriction-endonuclease	gnl|CDD|365904	pfam00145, DNA_methylase, C-5 cytosine-specific DNA methylase.	7.31567e-70

Protein sequences

>CP022041.2|ASE18220.1|413917_414274_+|hypothetical-protein
MKIIRILYNRLKNNRIKQRSTVIKIRKRNKTYYQTDMNLTKISYPKPPTKNPQNHETEMKTRLKTLVLQAYSKTENACTAPKTYVRQKGRLRPKTLFKVFFPQRKSIYFLKTKHLFLT
>CP022041.2|ASE18219.1|411927_412854_+|site-specific-integrase
MKTKTIREISLAWKRDKQRYVKQSTYAAYVLVLENHILSSFGDCDSLSEKLVQEFVLQKLNAGLSIKTVKDILIVLKMVMKFGVKNGWMNYCEWDIKYPTTVINKEMEVLTVTHHKKILDFIKQNFTFRNLGIYISLTTGLRIGEVCGLKWSDINTDSGIITVNRTIERIYIVEGERRHTELVINSPKTKNSCREIPMNKELLAMVKPLKKVVNINFYVLTNEEKPTEPRTYRNYYHRLMKHLDIPRLKYHGLRHSFATRCIESNCEYKTVSVLLGHANITTTLNLYVHPNMEQKKRCITQMLKYLRK
>CP022041.2|ASE18218.1|410662_411811_-|restriction-endonuclease-subunit-S
MLDFYSTNSLSWDKLEYGTNAIQNLHYGLIHVGLPTMVDLDNDKLPNIVSGNTPKNYELCQEGDIAFADASEDTNEVAKAVEFYNLNGKDVICGLHTIHGRDNQHKTIVGYKGYAFSSTAFHQQIRRIAQGTKIYSINSKNFSECYIGIPSKGEQKKIATLLRLIDERISTQNKIIDKLESLIKGICNNYFLKLSHSQEMKSIRLRDILKERNEYCCKDGTFVHGTLSKDGLFPKTERWNRDFLVKEENKKYKITHLDDICYNPANLKFGVICRNIYGDLIFSPIYVTFEISKKVNIGFIELYLTNRNFIEKIRKFEQGTVYERMSVSPEDFLSYKIRIPSLSEQTFFYQKIQRLKNCSQNELEHLNLYKKLRHYLLRQMFI
>CP022041.2|ASE18217.1|409446_410670_+|restriction-endonuclease-subunit-S
MTTTIDNEQKTLNVPNLRFPEFEGEWQEERLSDIADISKGIGISKDQLSADGEPCILYGELYTKYKSETIKEVISKTNIDNTKLVKSKANDVIIPCSGETAEEIATARCVLKDDVLLGGDLNIIRLHGYDGSFMSYQLNGKRKYDIAKVAQGVSVVHLYGEHLKNIKTINPSLNEQKKIANLLSLLDERISTQNKIIDKLESLIKGIMVELQKQGQNKGNWRNVLLSKVLKERDERNTNLYQVFSVSVSQGVINQVDYLGRSYAARDTSKYNVVHYGDLVYTKSPTGAYPYGIVKQNFNQENVAVSPLYGVYIPNSLSVGRYLHEYFRSEINTHNYLHPLIQKGAKNTINITNQRFLENSVPIPVCANELLLISKLLLSFNDKIKYQQSILQQYQKQKQYLLRQMFI
>CP022041.2|ASE18216.1|407855_409301_+|transcriptional-regulator
MEYIDFKKLIDALTAKPKETEWLEFKHNFHSKEEIGERISALSNSSYLCNMPFGYIVFGVDDKSHDVVGTDLYGKQIMVGNEELESWLSTRLNPRIDFEIIDDFNYEDKGHVCIFKIPATINRPVSFLHEAYVRVGTITRKLKDFPAKEAKIWKGDRKSLEKIVLKKGLSGQDVFSYLSAETYFDMMHLPLPQDTNGILDRFLAENLITKDEIGYSITELGAILFAKHLSDFDGLKRKMVRVIVYKGKNKIETIREQTFDKGYAIGFEEMVAWINSQLPANEEIGMALRKDARMYPEISIRELAANMIIHQDFAVQGFPMIEIYSDRIEFSNPGQPLISVERFIDEYQSRNDTLADIMRRMGICEEKGSGMDKTIFYVELYQLPPVRFQLYESRTTATVFSYRKFADLDKSERVRACYQHACLKYVSNEKMNNQSLRTRLGIEDKNYPMASRIIKDALEAKLIKEENAEGGNRHNYIPYWA
>CP022041.2|ASE18215.1|405740_407849_+|DUF262-domain-containing-protein
MKGYAKPLYEFIEGNKIQFVIPVYQRNYDWLIDNCDQLLSDLVKLSRLNRYSHFFGSIVTSSADNNSYNRLVIDGQQRLTTISLLLLAGIKAVKDDAIEISDKKRVEEAYEVFLNAKFCNAERKIKLVPIENDRIAYDKIFNGEGSFNEESKITRNYHHFYEKLTRRPQLLSFDQLLDAIERLQIISIELDKDDDAQLIFESLNSTGLALTEADKIRNYLLMSLTPEEQLECFKNYWQKIELATESQPTRFLRDYLTIKQQLQRPVRLSNIYYEWKKYMEGHDRKEELIEMLDYAHYYQQVVEAKLFTAKLSEKMRHICNIETDVANVFFIQFLKYASTNELSEAEMYKVIDLVENYLARRIVCNMPGNALTQVFCALHKDVLKSLEEYASANIELDYSYSDILTFHIMRRDGNYQLPRDVQFVESIKTRDAYHMLKPFQIFLFERLENSVHGEYNDVAIDMKKKDATIEHIMPQTLSGEWKAMLGDNFEEIQEKYLHTFANLTLTGINSELSNKPFAIKRDGKAIGNEIYPGYRNSKYRLTKNVTLCEKWTETELQNRSNEIVTIFLRLYPLPQTTFKPLPKPVDEVSLEEESFTPTNRQLKGFRLFGNEYTETTWKEMLLRVVKMVEQQYTDIVDTLYDAEGFFWSAQQADTRYCTQIAPQKYLWTSMDNRSKLRCLRFLFEKCDIAESELVMLLEPIRE
>CP022041.2|ASE18214.1|404165_405722_+|type-I-restriction-modification-system-subunit-M
MSEELQQKLRDQLWEVANKLRGNMSASDFMYFTLGFIFYKYLSEKIEKHANDALVDDEVTFKELWSMEKDTDIEELQESVKTECIENIGYFIEPNFLFSSVIESIKKKENILPILERSLKRIEDSTLGQDSEEDFGGLFSDIDLASPKLGKTADDKNTLVSNVLLALDDIDFGVEASQEIDILGDAYEYMISQFAAGAGKKAGEFYTPQEVSRILAEIVTLGHARLRNVYDPTCGSGSLLLRAASIGHANEIFGQEKNPTTYNLARMNMLLHGIKFSNFRIENGDTLEADAFGDTQFDAVVANPPFSAEWSAADKFNNDDRFSKAGRLAPRKTADYAFILHMLYHLNEGGTMACVAPHGVLFRGNAEGVIRRFLIEKKNYVDAIIGLPANIFYGTSIPTCILVFKKCRKEDDSILFIDASKDFEKIKTQNKLRPQHIQKIVDTYRDRKEIEKYSHLATLEEIAENDYNLNIPRYVDTFEEEEPIDIHAVMKEIKDLEAKRADLDKEIEGYLKELGLVE
>CP022041.2|ASE18213.1|403513_404164_+|hypothetical-protein
MIKIIRGLDITALGVCVYNRKWQSVHLQQGDMDGACAVYSMMMNLIVLKVFTRNQVTNLNTSFKGNTAKGRLFKEFFVKEGLCRDGFYFSEIKEKLSHSFAKEVMSSARQYMISQSAQASYVEELKKGIDDNLPLVTAITFKGGAHAILAIGYEEEEGVIRKIFCLDPGHAISQTALWNSVIILNEGKGMYCHQYITDKDDENVFVSETLKIERKK
>CP022041.2|ASE18212.1|400658_403502_+|type-I-restriction-endonuclease-subunit-R
MPVQSEAALENGLIATLQQMNYEYVQIEEEKNLRTNFKSQLEKHNRKRLEEIGRTEFTEAEFEKILIYLEGGTRFEKAKKLRDLFPLELDNGERLWVEFLNRTHWCQNEFQVSHQITVEGRKKCRYDVTILINGLPLVQIELKRRGVELKQAYNQIQRYHKTSFHGLFDYVQLFVISNGVNTRYFANNPNSGYKFTFNWTDAANVPFNELEKFATSFFDKCTLGKIIGKYIVLHEGDKCLMVLRPYQFYAVEKILDRVKNSNNNGYIWHTTGAGKTLTSFKAAQLVAELDDVDKVMFVVDRHDLDTQTQSEYEAFEPGAVDSTDNTDELVKRLHGNSKIIITTIQKLNAAVSKQWYSRRIEEIRHARIVMIFDECHRSHFGDCHKNIVRFFDNTQIFGFTGTPIFVENAVDGHTTKEIFGNCLHKYLIKDAIADENVLGFLVEYYHGNADVDNANQNRMTEIAKFILNNFNKSTFDGEFDALFAVQSVSTLIRYYKIFKSLNPKIRIGAVFTYASNSSQDDALTGMNTGSYVSESTGEADELQAIMDDYNDMFGTSFTTENFRAYYDDINLRMKKKKTDMKPLDLCLVVGMFLTGFDSKKLNTLYVDKNMDYHGLLQAFSRTNRVLNEKKRFGKIVCFRDLKSNVDASIKLFSNSNNLEDIVRPPFNEVKKNYQELTTNFLEQYPTPSSIDLLQSEKDKKQFILAFRDVIKKHAEIQVYDEFEEDAADLGMTEQQFMDFRSKYLDIYDTFAGGCKPSEENQTPDEDTESTETSTESGIDDIDFCLELLHSDIINVTYILELIADLNPYSADYKEKRTYIIDTMIKDAELRNKAKLIDGFIQQNVDDDRDNFMARKQKFDGTSDLEERLNNYITTERNNAVDKLAKEEGLDVTVLNHYLSEYDYLQKEQPEIIQEALKEKHLGLIKKRKTLTRILDRLKSIIRTFSWE
>CP022041.2|ASE18211.1|400372_400618_+|XRE-family-transcriptional-regulator
MYLRILQYTMINQQKKAIYRIKAVLAEKQLSGKWLANEIGRTENTVSRWCSNKVQPFLENLLEIAKALKVDVRDLLRSTEE
>CP022041.2|ASE18221.1|415426_417289_+|DUF4268-domain-containing-protein
MGLNNRLQIGDVSNNGQVEIVDEDRLCYLVRSTSKGATGLRTISKSLLEEYVNYWSEHSDATSESARQALSGTSEIDKYEYGYTSTLSVMAQMVLQSTHKVKNNVSSLPRQQIFYGAPGTGKSFTINQEIKGEDVIRTTFHPDSDYSSFVGAYKPTTREITMRDLSGHPVVEHGQTLTEEKIVYEFVPQAFLQAYIGAWEKYAACDEGNPHRQFLVIEEINRGNCAQIFGDLFQLLDRNHSGFSDYPVKADTDMKRYVAKALKGLTIPQAGAINSLYGGRDVVSEVLEGNILLLPSNLFIWATMNTSDQSLFPIDSAFKRRWDWSYMPISDAKKGYVIDVAGSQYDWWQFLEEINEKIENTTNSEDKKLGYFFCKAHGGVISAETFVGKVVFYLWNDVFKDFDLVGPIFDDTVEGGRLTFAKFYTEGEMKTKVRAEKVAQFLGNLGLTPLEESEEEYNGQAESTDDSENPRATWSVTERKRYDFWQAFLAYAQKNDEFKTYFGGTKKAGKDHWKNFYVSGADFYMSVVLKLWERAIALQVYFDRTTDTYYHLATQKKEIEAEMDTTYEWRENPEKKSSTIVERIDDIDFEDKEHWTTIFDLIITRTLRMREVFVKYSKQQ
>CP022041.2|ASE18223.1|419750_420530_-|hypothetical-protein
MAKVNYPKGEKLARLLLDVLAKEPSYKEHSKGLPYYYISFEGQEYYLYFKCITHEGNPYPLEHRRSQLPQRPEFDKIKNDNIPFLFLGYDIDNDLFVCWEPAKVKPRLNNRSYVSFYSRLSIQESVEEGKIRDEYLTNGDKFVLFKRVDAVSFFQMIDTHFEELKHDDTQTDTRSVSEPPTDYNTQKKLGNHVQGRIVSVEEDVSIQLKIDSMAQNNSVLEIVADCMNEFSTYYPKMSFADWSQVIRKYLQNDNNLYKR
>CP022041.2|ASE18224.1|420531_421500_-|PD-(D/E)XK-motif-protein
MSNLYSTYSQLRERRKESGLYEVEDFIIGKPHKFGATEDGFPVIFVECCDDAVSTPIRLKAISVDFSQLCTLKDAGGETLTKKYTIIVLNSLEADLQSYFLEVFAMVLNKFSSTPSVSLLKAEISKVAKIFMMPPSFSAVVIQGLWAELFVIANAKSPEDLAKAWHVTAEDKYDFNDGKDKIEVKSTSNLDRVHTFALEQLNPNAGSELAIASVITVRSGQGVNVFDVLDTISQRGLSIEQMSKIQEIAYLTIGPHLEEAKKIKYDFTLALNSYMKFDYRDVPSIKSEHVPSGVTSVHFASCLKDVEPIDLSATNSGLLKFM
>CP022041.2|ASE18225.1|421517_423731_-|endonuclease
MSSTIQVINPTNKQNNQVVIGNNTLHFMDSQSKLDDEGKSIIIDEAMKILSHCVKPGTNDSITNIAVGYVQSGKTLSFTTLTALAADNGYRMIIYLTGTKTNLEKQTSDRLASDLDTDSSDVYNLMSGIDDNFTLDTSIKNFLIHTDDVILIPILKHYKHIQRLADTFVSPTLKSCLNNLGVIIIDDEADQSSFNTFAKKNTANPDWIEDDFSKTYASILALKKSLPNHSYIQYTATPQAAFLIDNSDILSPTYHTVLTPGKGYTGGKFFFKNKNYQLVHLVDDAEVYHHKRNPLTTTPKSLIESLQQFLVSVAIVVFIQKRKNVDFLSMMIHVDGRCDTNTLFANWTKNALQQWIDILTLDEKDPGRKLVCKKFKNAYDEMTRYIQNPPSFDEVMKNMVKVILRTKIHLVQSQGGSVGDDGISWKSAKANILIGADMLNRGFTIEKLSMTYMTRTTQGKSNADTIEQRCRFFGYKMDYADICRIYLSKKSLVEYNDYVEHEETLRANLSQCETLEEFSKHSHAMLLAETLNPTRTNILSSKLVRNKLSGWKQMPSLDCIDNNKILFESFLSNIPSTAYTDCENYGNNPIRNHRWVNIPINDFIDFFKLVKYEDAPNITRKIVTIQYLYYLRDSVNVDHIRLYEMAYKATVQSGDIRTRSIKDDKPNNLQAGRAANGSYPGDIKFCTDNEVCVQVHHIKIKQPLHRLNSKDLYNLCIYYPENLATSFVGLDSDDEDD
>CP022041.2|ASE18226.1|423743_425309_-|ATP-binding-protein
MPSNVSIATRPLVYSTFRYISNKVWNALAEYIDNSIQSFLDHQDVLSKINPDGIKLRVSINMDFENDTIIIEDNAFGITEENYQRAFELANIPLDNKGLNEFGMGMKVSSIWLSNVWKVETTAYGDDVLKTVTFDLNEVVENEELSLPVTEESCDKEAHFTRITLSHLSGNKPTPRQLSYIKKHLASIYTLHLRKQTLELIVNDEPLEYKELTILNAPKYNEPNGKPILWKKDINLTFGERYAISGFIALLDTMSTSIDNGFLLFRRGRVIGSSYDERYRPKELCGQEGSPLYKRVFGELYLTGFDVSFTKNSFQEDDDFAELIKLLREDLNKDKTFDLFAQGQHYTKPRTQKEIKNIGTKLVKQIISGFTKPIVHTPSTTISTPNDTTPKKPALVIPVTTPQTQAKVEQIKSTPTDLFDGIPVDILLDNNEKVELTIKTGEAVAGLYTFNEIADDKYEATINLKNNVFQRFASSLSTQEGQEQLSYMIEVMVASEISMIKGGSDAATKFRSTFNNLFGTI
>CP022041.2|ASE18227.1|425298_426660_-|restriction-endonuclease
MAKKKQLQFIDLFAGLGGFHLALSKLGCKCVFSSELKEDLRKLYQINYPGVRIEGDITKIAPKDIPAHDIICAGFPCQPFSQAGNRQGFNDEKGRGTLFDYIIDIVAYHKPKYIILENVSNLKGHDNGNTWRIIQEKLDEQEYSVKAEILSPHEFGIPQHRKRIYIVCIRKDLGLLDNFTFPKGNKPVCDVNDIIEANAKDITPIKEETHYQLNIWQEFIDKTIANGGTIPTFPIWAMEFGASYDFETVAPAFQSIEQLVEKKGKLGKIIRGTTLKECLAQLPNYSQTDKTRVFPVWKIRYIQQNRDFYNKHKSWLKGWMKKVVHFENSHLKMEWNCGVNVEPHIENKIVQFRASGIRVKKPTFVPALNLVGTQVPIFPWIELPKDMQKPEIGLTKGRYMTLHEAASVQGMRELSFGNDDFRLSLARSYEALGNAVNVELVKMIAKKLLDYAK
>CP022041.2|ASE18228.1|426671_426869_-|XRE-family-transcriptional-regulator
MEDINQIKLALVKSKKTNKWLAEQLKVNPTTFSKWCTNTTQLNLYTLKKIAGLLNIPVSELIVSE
>CP022041.2|ASE18230.1|428062_428548_+|peptidase-M15
MINDSHSNEIDFEERLSPHFTVGEMMRSGKAVGMGIKNVPEENPAPGEASRAEVIENLRELCRCVLEPLRRRVGRVIVVGGYRCEAVNRAVHGAEHSQHLRGEAADIHVTGLEMCRKYAAILSQTDFDQMILEPQESIKKRWIHISYRRDGKNRHQILGAK
>CP022041.2|ASE18231.1|429165_429687_+|DNA-binding-protein
MSIKFRMYQDNRKNSKRKGYWYARAVSPDLVSVKDLALRISERCTVTEPDILAVISALVFEMNQVLKDGNRVKLDGLGTFRVGIHSQGVQKAEDFNAQRDIYGAHVLFSPTVTIDAMKRRVKTLISGLRIQEAVQYDAPKAAEKAKNKGKKKENKPSAGPEPGEATATTEGHA
>CP022041.2|ASE18232.1|431479_432805_-|Na+/H+-antiporter-NhaA
MRQRVEKKLNQHLMLPIKLFMGREKSGGIVLILSVTLAMILANSNIAESYFHFFEQEVGFIVNGEPYLNYSLHHWINDGLMAMFFFVVGLELKREFIGGELADIRNTILPIGAAIGGMIVPALIFLSLNIGTPQTMGWGIPMATDIAFALGVVYLLGDKVPASAKVFLTTLAIVDDLGAVLVIAFFYTSELSIASLLFGLGFLAVMFIGNRLGIKSLFFYAALGIGGVWVTFLLSGIHATIAAVLAAFMIPADAKINESVYLKRMKKLTRRFEKEEPNEVRTLEEGQVDVLTHIQHDTEIAIPLLQQLEHKMSPIVTFLIMPIFAIANAGISFTDLSLSDIFSTHVALGVTLGLLLGKPIGIIGATFLMVKMRWATLPSAITRRTLLGLGMLASIGFTMSMFISTLAFTDELLMTQAKLGIFLASILGGIGGYVLLNKKSK

Crispr_ID: CP022041_5

• CRISPR_ID: CP022041_5
• CRISPR_location: 479024-479203
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of CP022041_5

Consensus_repeat	Method
TTGTCTACTTACCATGTTACTCTGTCTTTTATTTACCCTATCTACA	PILER-CR

spacers of CP022041_5

>5.1|479076|37|CP022041|PILER-CR
CTTTGCAAGCAACTGGTTCACTCGTCCACTCGTTGAC
>5.2|479165|28|CP022041|PILER-CR
AGCAACTTGTTAACTTGTCTACTCGTTG

CRISPR arrays and Neighbor proteins around CP022041_5

CRISPR arrays

The CRISPR arrays of CP022041_5

>merge|CP022041|5|479024-479203|PILER-CR
CATGTTACTCTGTCTTTCTTTGCAAGCAACTGGTTCACTCGTCCACTCGTTGACTTGTCTACTTGTTAACCATGTTACTCTGTCTTTTATTTACCCTGTCTACAAGCAACTTGTTAACTTGTCTACTCGTTGACTTGTCTACTTACCATGTTACTCTGTCTTTTATTTACCCTATCTACA

>CP022041|5|1|479024-479203|PILER-CR
CATGTTACTCTGTCTTTCTTTGCAAGCAACTGGTTCACTCGTCCACTCGTTG	ACTTGTCTACTTGTTAACCATGTTACTCTGTCTTTTA
TTTACCCTGTCTACAAGCAACTTGTTAACTTGTCTACTCGTTGACTTGTCTA	CTTACCATGTTACTCTGTCTTTTATTTA
CCCTATCTACA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18264.1|474840_475965_-|sugar-transporter	unknown	unknown	unknown
CP022041.2|ASE18262.1|473805_474324_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18267.1|477500_478010_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18260.1|472426_473329_-|hypothetical-protein	unknown	unknown	gnl|CDD|293786
CP022041.2|ASE18903.1|482812_484384_+|carbohydrate-binding-protein	unknown	unknown	gnl|CDD|373012
CP022041.2|ASE18271.1|486699_487764_+|hypothetical-protein	unknown	unknown	gnl|CDD|271342
CP022041.2|ASE18904.1|485419_486697_+|DUF4302-domain-containing-protein	unknown	unknown	gnl|CDD|372921
CP022041.2|ASE18268.1|478282_478780_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18263.2|474433_474814_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18266.1|476739_477201_+|guanylate-kinase	unknown	unknown	unknown
CP022041.2|ASE18272.1|488076_488544_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18275.1|491727_492381_-|rubrerythrin	unknown	unknown	gnl|CDD|153100
CP022041.2|ASE18269.1|479485_482800_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
CP022041.2|ASE18258.1|471556_471922_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18261.1|473336_473741_-|hypothetical-protein	unknown	unknown	gnl|CDD|184930
CP022041.2|ASE18270.1|484395_485283_+|hypothetical-protein	unknown	unknown	gnl|CDD|275342
CP022041.2|ASE18273.1|488952_489396_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18259.1|471908_472376_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18274.1|489890_490322_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18905.2|488527_488953_+|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|238045

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18269.1|479485_482800_+|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	6.21369e-179
CP022041.2|ASE18270.1|484395_485283_+|hypothetical-protein	gnl|CDD|275342	TIGR04549, LP_HExxH_w_tonB, substrate import-associated zinc metallohydrolase lipoprotein. Members of this family are lipoproteins with the typical zinc metallohydrolase HExxH motif and additional similarities to a better-documented zinc peptidase family, pfam06167. The seed alignment begins immediately after the lipoprotein motif Cys residue. Up to five members of this protein family occur per genome, in the context of certain gene pairs related to RagA and RagB, or to SusC and SusD. Those gene pairs, like the present family, are restricted to the Bacteriodetes, may number up to 100 pairs per genome, and are linked to TonB-dependent uptake of biopolymer-derived nutrients such as glycans. A possible function for this lipoprotein is to hydrolyse larger molecules to prepare substrates for import and utilization. [Unknown function, Enzymes of unknown specificity].	4.36468e-130
CP022041.2|ASE18904.1|485419_486697_+|DUF4302-domain-containing-protein	gnl|CDD|372921	pfam14135, DUF4302, Domain of unknown function (DUF4302). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 344 and 443 amino acids in length. There are two completely conserved residues (R and L) that may be functionally important.	1.45701e-59
CP022041.2|ASE18260.1|472426_473329_-|hypothetical-protein	gnl|CDD|293786	sd00045, ANK, ankyrin repeats. Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.	2.81762e-13
CP022041.2|ASE18903.1|482812_484384_+|carbohydrate-binding-protein	gnl|CDD|373012	pfam14322, SusD-like_3, Starch-binding associating with outer membrane. SusD is a secreted polysaccharide-binding protein with an N-terminal lipid moiety that allows it to associate with the outer membrane. SusD probably mediates xyloglucan-binding prior to xyloglucan transport in the periplasm for degradation. This domain is found N-terminal to pfam07980.	4.18612e-26
CP022041.2|ASE18275.1|491727_492381_-|rubrerythrin	gnl|CDD|153100	cd01041, Rubrerythrin, Rubrerythrin, ferritin-like diiron-binding domain. Rubrerythrin domain is a nonheme iron binding domain found in many air-sensitive bacteria and archaea and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The homodimeric rubrerythrin protein contains a binuclear metal center located within a four helix bundle. Many, but not all, rubrerythrin proteins have a second domain with a rubredoxin-like hexacoordinated iron center. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system but its function is still poorly understood.	2.66247e-58
CP022041.2|ASE18261.1|473336_473741_-|hypothetical-protein	gnl|CDD|184930	PRK14966, PRK14966, unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional.	0.000203992
CP022041.2|ASE18271.1|486699_487764_+|hypothetical-protein	gnl|CDD|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	7.69962e-08
CP022041.2|ASE18905.2|488527_488953_+|XRE-family-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.68133e-09

Protein sequences

>CP022041.2|ASE18268.1|478282_478780_+|hypothetical-protein
MVLKDVSYLKRGNYIYMYGHWLNMEFSQEFDTSYWKIFTENDFFLKLGFRKENNYYKLYIPYGRSYGYSAFYKYCYCKYQGGKYTPNTVVSDGNIILFPDLETQTCLLGFLDNGDHYIEIPYKKFIEEVTDIWEERTPIEGFKFDVEPIVYLKKDGVWLKEPKEQ
>CP022041.2|ASE18267.1|477500_478010_+|hypothetical-protein
MMKIEKKVGKRILINGKELRLDTYCNNDNMWFWYIYTKEEVDSRLFSKSGEYFKLFLKMDQKYPYSAYESRMYCIYLGYKYEVENIWHGLFILSPNERKTRRHLKLNDHDDSRIEVPYEEFIASSPIIWEERKPISDFVFDVEPLVYLFKDNSYIEENLHGAWYKRNIK
>CP022041.2|ASE18266.1|476739_477201_+|guanylate-kinase
MRTYKRGNFAIYLSQEYYFYKTDNPDMFELIDRKCQYEKLSKIGFLQHNNIISYKYVSKKDISSAFNTITFVKYKGFNFFVENSSEGKFILRPLEEAMKYFKDFPRHGYDPIYEAMEEEISDIWEERRPIEGFKFDVEPIVYLKKDGIWLVEE
>CP022041.2|ASE18264.1|474840_475965_-|sugar-transporter
MAIKLNRGITHAEKEIKEGDIFYVYNDYYKKYFFGKILVDISRLTKQVGKDSALDFFSDCYLVAVYKEISDTPELHSREFIIPGSFIYKSSFKRRNRQGFDWTHYAYEAVDFHTLDFPEFFLNYDDGVYLVRGELKFRTELSRQQEEEYKIRGSKSGSIDYSSALLLQGYKAYSDRINYHDLRLLPELRKSIYDMIGEDASMSYYNLALKYGKDTGRLFTDALPEEVQQIKPVETDQRTGFPKELLCGIAWSFRQQRYYSLAAFADELQAYNEEITGEYTPGVWTDELKLIGSRILVQYEHWDDELEESREEKVFLQADNGSYFTVSELIYKIHNHVCDKLVNDDNVFFEGLQLFERDDVNHPRTPYYFILQGS
>CP022041.2|ASE18263.2|474433_474814_-|hypothetical-protein
MFKKILGDKYTRANNIAKSVRSLQRVPEKERPRIVKKAVLNVYVIGSIIILISLWLYFFGNEIMAIPIGNNLEGETFRSRRANLYLHLLVPVFIPVIFIFGIPLLIRNYIIKRIVDKEFPKERRRM
>CP022041.2|ASE18262.1|473805_474324_-|hypothetical-protein
MNLKKILKEEATWCFLALAGLLILLYVGAYVIIDTYFYMISLNILIFLFSYIILKIKNKLHYYSYVVGCAFFVVWLIFYIICDLKSRSLKGYLTKQLPVLFYIPTGSGGRGSSSGIEVECKGNQHKISTTHESDSLYQIYGDSVINHIVVRYVLKEPFPHVYYIDRMQITYK
>CP022041.2|ASE18261.1|473336_473741_-|hypothetical-protein
MNMRIITFIGLITFIISCFLPCFSVRDSSFDYMGYTALFLGWAGVFINSKLTVYYISWYANILFLISLFIKRKYIGIILLTGSLILGCLFHGCPYIVINEAGKHSDIVSLQIGYYVWILSFFILLIGRILRYKE
>CP022041.2|ASE18260.1|472426_473329_-|hypothetical-protein
MSMKYLLLLVLFVGFSCIEPNVKDMLGDDFRLYKHTPAWSFAEAVEDEDTTEISKQVLQMHIPVDYRDPKYKQTLLMLATRTNKIESVEKLLELGANPNAHDDSTKYFGESAVLLACRFTRPSSKVLALLLKYRGDPNSTACGVKEDGLGEIVPMRDFALSAAVFSSFEKVKLLVDAGANINYATSTGNCAIENCMFHDRMDIMLYLLQKGADYRRKFTEIDVDKPDYPTFEVDILYKLRKCVYPIGSKAYKEKMKVVNFLKRKGLDYWKSPIPSGMYGVIMREIAPKNKADFDYYIKHY
>CP022041.2|ASE18259.1|471908_472376_-|hypothetical-protein
MNIEIIDYDTYKRLNYDSVFKDYHNDSYRIYGKIVEGDSYAKIAWSSDLLQPQFIEVFPKIFAIGIDQDFAIYDFDLKRRIMYLDLGFLFCEMAIFEKKILIATELEVIVIDTQQYKVIDTIPLQDTYDKMKINCGEVEIYCMDHSFEKCHIGNK
>CP022041.2|ASE18258.1|471556_471922_-|hypothetical-protein
MAINKGSSEIWSDKVSLLHIKGTQRGGEHGGESKQSHGGAEGTKSDRAVVYVLLIALVINVLRNLAKQMFCNEVDKNISKTRKHPLFLHAPTVPLCLTTSAIEKYAALFGYSKSCSYICEQ
>CP022041.2|ASE18269.1|479485_482800_+|SusC/RagA-family-TonB-linked-outer-membrane-protein
MSKKLLMCFAMLFMCVSAALAQTKISGTVVAADDNEPVIGATIMVVGTKSGAVTDVDGKFSLTTDVANPQVTVGYIGMASQTLKGTTDMKVVLKSSTQTLNEVVVTGLTRTDRRLFTGATDKVDAEKARLSGVADISRSLEGQAAGVSVQNVSGTFGTSPKIRIRGATSIYGSSKPLWVVDGVIMEDAANVGADDLASGNPETLISSAIAGLNADDIESFQILKDGSATSIYGARAMAGVIVVTTKKGKQGQAHISYTGEFTSRLVPSYSNFDILDSKEQMGIYRELADKGWLNFSEVLNGSEYGVYGKMYELINTYNARTGRFALENTTEARNRYLQRAEFRNTNWFKELFSSNIMQSHSISLSGGTQKSNYYASFSALLDPGWYKQSNVNRYTLNVNLTQHLSDKLSLNLIGGAAYRKQRAPGTLGQDVDVVGGEVKRDFDINPYSYASNTSRVLDPSATYVANYAPFNIFNELNNNYIDLNTLDARFQLELKYKPVKGLELSLLGAFKYMASTQEHFVKDESNQALAYRAMSNGIIRDANKYLYKDPNNPYVLPMTVLPYGGLYHRGDNRMSDYDIRATANYSHTFAEKHIMNLFGGMELTSIERQRNAFEGVGLRYDAGMVPFYIYQYFKRALESGNTYYTINPTNSRSVAFYGNTTYSYQGRYVFNGTLRYEGSNQMGRNSSARWMPTWNVSGAWNVHEENWFNKLSPLNKLTLRASYSLTGTPPDASYSNSTAIITASTPFRLFAEDQEPQLELSELANSTLTYEKKNELNLGFDASLWNNRLGITFDYYTRRNFDEIGPMVTAGLGGEIIRAANVAEMNSNGLELSISSVNIKKKNFSWTTSFIYSYATTEITKLFNQGNVMSLVSGNGFAKKGYPARALFSIPFMGLNSDGMPMVLNEKGQVTTDDINFQERTKTDFLKYEGPTDPPHTGSLGNMFTYRGFRLNVFFTYAFGNVVRLDPKFRARYNDLVSMTNAFKNRWMAAGEEKETNVPGILSKSQYMANTNVRLGYNAYNYSDARIAKGDFIRLKEISLGYDFPAQMFQSSMIKNVSLKLQATNLFLLYADKRLNGQDPEFYNVGGVASPMPKQFTLTVKLGL
>CP022041.2|ASE18903.1|482812_484384_+|carbohydrate-binding-protein
MKVKKYILYLPVAALALALTSCNDFLDKYPDSRMDLKNPTEVSQLLVSAYPQAHPAYLTEMYSDNTDEQLHSTWSAFDRFQEQAYQWKDIDDVSNTETPYQLWSAHYAAISSCNEAIAFINSVSNQDEYQEQLGEALLCRAFSMFQLSTVFCQAYDKTTAAKELGLPYPTEPEKVVGRLIERGTLAELYQKIEADMLKGISLVGTKYAKPKFHFTKQAAYAFATRFYLYAQQYDKAVKYANMVLGDQPADILRNWAEWNRLGPSGNVQPNAFVNASNNANIMLLPVPSQWGVISIPIQAGSKYAHGELISKNETLQAPGPWGDSGSTLNYTVLYNNGVSKYCLRKLPYVPKVIDATAEIGVPYGEYAVFSTDITLLERAEAYALLGQYDKALKDINTELTVFSKNRKQLTLADIQDFYGSMTYYTPTKPTPKKKLNPLFTVEATTQEPLLQCLLQLKRLVAIHEGFRLQDVKRYGITMYRRKVDVQSNVTAVTDSMKVGDPRLAIQLPQDVITAGVTPNPRNN
>CP022041.2|ASE18270.1|484395_485283_+|hypothetical-protein
MKKYLYLVAITLVSCGAVLSSCSDDKISGDSIFSTKAVERNAFDQWLYKNYTMPYNIDFQYRLKTEETEQAYNFVPADSAKTVKLAILTKYMWFDAYAETVGLDFIKENAPRIILVTGTPGYTRYRTEVIGSAEGGYKVRLGKVNALTDDQLKDYGSMNNYYFHTMHHEFMHILNQKKPYDESYDNISRSDYVSGNWTSIPDKKAQSMGFVSAYSMENPAEDIAELYSIYVTSTPEDWATIMKNAGNKGGTIINKKLKIIREYMSNSWNVDIELLRNAILRRGGKIGTLDLNTLE
>CP022041.2|ASE18904.1|485419_486697_+|DUF4302-domain-containing-protein
MKKVYLLFMAIVLTLSLQSCLHDDKTTFDLPAAERIEKKVADYKALLESSEDGWVMQYYTGKNYSYGGYTLLLKFKDGHVTAMGDVKDVEAQATSGYDVVKDLGPTLSFNEYNAVIHPLAETWLGSPDGAQGDYEFSILRATNDSIFLKGRKWHNEMVLTRLPKGTSWEEYMLGLVTVMEGMNVETYDFVLGNDTLAQGTLTQEVRRLTVTLGDKKWEMPYCTTNTGITLREPIVIGNKKYQHFTWNDADHSLTQDDLKIIQFLPKSHKNIDFWIGEWQLKTNLRKRIKLTLEMGSVANTLKGKLNINNINYEILLTYDPATGHLELPGQPVTDPTYKYPAGIVMIPASQKEGKLFGEGKGSLFFTWDEDMQRAKAEDSGQITGHAVDSFFGVAYGEDLQPVTDAQGNYVFAFTLPNIQYMTKIN
>CP022041.2|ASE18271.1|486699_487764_+|hypothetical-protein
MKKYISIFLLVAAAVLGTACSNDNNELPEYAAGLKVVKAQTAFNVIGGANEVKMASEPAQAYAQDAWLTVTKKAETLLLTATTNTSPQTRNTLLVIKDAKGDSITLNVQQEGITFGLPAGQDIFTDDKAVQKTLIATANVPVTYTTTGDWLSVAEQGSEITVKAAENTTGKARVGWVIAKAAGLVDSLKVVQASLADFVGEYKQTAKMRNADRTLSERTSDVRIEATGTNKANFIVDNKYTWAVDFIPGSGFKMTNGKVVAKNEVQTGVYEYFISVIVADDFSKEHETAINGTQESILLSIDDAGNLVFKEAQKLASEQTFSSYGWNRFSDSKPVMGAYRGIGEVYVQPKLTRK
>CP022041.2|ASE18272.1|488076_488544_+|hypothetical-protein
MSFRIVEMKDLSGAKAHIYSVKFDGYDETLLDCFFNENEDNKNLQEMLHKIIVMATKTGCLKQFFKEGEGSLADGVVALSVGNLRLYGIYFNNTVVLLGSGGEKNVRAYQHDPILNAKVEQIKYVAKKINKAIVERDIIVSEDGELNLDNFEVYE
>CP022041.2|ASE18905.2|488527_488953_+|XRE-family-transcriptional-regulator
MKCMSKMQVKKNVLSQLLSTIDEVALKKTSNRMMIAAKIGNALKDKGISQKEFAKKLKKSESEVSSWLSGDRNFTIDTLTEISLALDISLLDTEVQSVYSFPTRIFLPETGNVSNTKISVSSQWTCSLGYIDCRNKTQKVG
>CP022041.2|ASE18273.1|488952_489396_+|hypothetical-protein
MKNGDKIEFAIVGMQEDSYKVNYDIDFSKLNQEELEFQIEQRINVSAEPENIIISMRVHLMNGAEEIAMQGVRAIFKVKPFNSFVNDMQEDDLKVSNPALIDTFISVCIGAIRGMLVKNLKGTPLDNVVLPLIPMNVIRANSTKRTK
>CP022041.2|ASE18274.1|489890_490322_-|hypothetical-protein
MNTLKISIITCFSILYSLTSFAEVKSNVSIEIGSFDSIPSEIDGGCCVFYKYPNKMRNKSYIMVNDLATTAYMMINRHLEEFTLVSNQKDIFWYKNKRFTLKVTINHTQSKGDNECYKVKGILIVEDRNKNQRKLSFCGNCSW
>CP022041.2|ASE18275.1|491727_492381_-|rubrerythrin
MKKKFICTVCGYIHEGTEAPAECPVCHAKAAKFKEFNPEALKGTKTEQNLKNAFAGESQAHTKYLYYASKAKKDGYEQIAGFFEETARNEKEHAKIWFKFLHEGDIPTTTQNLADAAAGENYEWTDMYEQMAKDAMEEGFPELAVKFRSVGKVEKHHEERYRKLLKNIEDSVVFSREGDCIWQCRNCGHIVIGKKAPAVCPVCNHPQSFFQVEESNY

Crispr_ID: CP022041_6

• CRISPR_ID: CP022041_6
• CRISPR_location: 507107-507208
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_6

Consensus_repeat	Method
ACCTCCCCCGACCCCTCCAAAGGAGGGGAGTGCCTAA	CRISPRCasFinder

spacers of CP022041_6

>6.1|507144|28|CP022041|CRISPRCasFinder
CGGAGTGAGAGTTAAATCAAAAGCAGGA

CRISPR arrays and Neighbor proteins around CP022041_6

CRISPR arrays

The CRISPR arrays of CP022041_6

>merge|CP022041|6|507107-507208|CRISPRCasFinder
ACCTCCCCCGACCCCTCCAAAGGAGGGGAGTGCCTAACGGAGTGAGAGTTAAATCAAAAGCAGGAACCTCCCCCAACCCCTCCAAAGGAGGGGAGTGCCTAA

>CP022041|6|5|507107-507208|CRISPRCasFinder
ACCTCCCCCGACCCCTCCAAAGGAGGGGAGTGCCTAA	CGGAGTGAGAGTTAAATCAAAAGCAGGA
ACCTCCCCCAACCCCTCCAAAGGAGGGGAGTGCCTAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18273.1|488952_489396_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18283.1|507552_507756_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18280.1|503476_505174_-|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl|CDD|236992
CP022041.2|ASE18278.1|501130_501901_-|NYN-domain-containing-protein	unknown	unknown	gnl|CDD|350289
CP022041.2|ASE18285.1|510145_513265_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|274948
CP022041.2|ASE18275.1|491727_492381_-|rubrerythrin	unknown	unknown	gnl|CDD|153100
CP022041.2|ASE18277.1|497629_500824_+|hypothetical-protein	unknown	unknown	gnl|CDD|379166
CP022041.2|ASE18282.1|506532_506802_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl|CDD|274507
CP022041.2|ASE18281.1|505443_506262_-|KilA-N-domain-containing-protein	unknown	unknown	gnl|CDD|367917
CP022041.2|ASE18276.1|493180_496975_+|DUF5110-domain-containing-protein	unknown	unknown	gnl|CDD|269882
CP022041.2|ASE18279.1|502367_503213_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|369630
CP022041.2|ASE18291.1|520656_521109_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase	unknown	unknown	gnl|CDD|379112
CP022041.2|ASE18284.1|507783_509490_+|hypothetical-protein	unknown	unknown	gnl|CDD|372499
CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR	unknown	unknown	gnl|CDD|234616
CP022041.2|ASE18274.1|489890_490322_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18293.1|521908_522388_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|224137

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein	gnl|CDD|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	6.12833e-47
CP022041.2|ASE18280.1|503476_505174_-|energy-dependent-translational-throttle-protein-EttA	gnl|CDD|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
CP022041.2|ASE18285.1|510145_513265_+|TonB-dependent-receptor	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
CP022041.2|ASE18275.1|491727_492381_-|rubrerythrin	gnl|CDD|153100	cd01041, Rubrerythrin, Rubrerythrin, ferritin-like diiron-binding domain. Rubrerythrin domain is a nonheme iron binding domain found in many air-sensitive bacteria and archaea and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The homodimeric rubrerythrin protein contains a binuclear metal center located within a four helix bundle. Many, but not all, rubrerythrin proteins have a second domain with a rubredoxin-like hexacoordinated iron center. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system but its function is still poorly understood.	2.66247e-58
CP022041.2|ASE18277.1|497629_500824_+|hypothetical-protein	gnl|CDD|379166	pfam13402, Peptidase_M60, Peptidase M60, enhancin and enhancin-like. This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonisation of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.	1.46764e-33
CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein	gnl|CDD|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	2.71626e-55
CP022041.2|ASE18281.1|505443_506262_-|KilA-N-domain-containing-protein	gnl|CDD|367917	pfam04383, KilA-N, KilA-N domain. The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.	2.07193e-11
CP022041.2|ASE18276.1|493180_496975_+|DUF5110-domain-containing-protein	gnl|CDD|269882	cd06596, GH31_CPE1046, Clostridium CPE1046-like. CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type C domain in addition to the GH31 domain. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.	0
CP022041.2|ASE18278.1|501130_501901_-|NYN-domain-containing-protein	gnl|CDD|350289	cd18722, PIN_NicB-like, LabA-like PIN domain of Pseudomonas putida S16 NicB and related proteins. Curiously NicB from Pseudomonas putida S16 is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine. This subfamily also includes the uncharacterized CPP15 (plasmid) protein from Campylobacter jejuni. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.16447e-25
CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	3.91272e-58
CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.39499e-24
CP022041.2|ASE18284.1|507783_509490_+|hypothetical-protein	gnl|CDD|372499	pfam13149, Mfa_like_1, Fimbrillin-like. A family of putative fimbrillin proteins found by clustering human gut metagenomic sequences. Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.	2.05988e-05
CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR	gnl|CDD|234616	PRK00076, recR, recombination protein RecR; Reviewed.	6.95636e-114

Protein sequences

>CP022041.2|ASE18282.1|506532_506802_+|hypothetical-protein
MEESPSAYRWFGYMFVWMLACLLILDKGVSSELFLFILLLVAIVLNAYCAYKFALGKGTFLAILAFVVAMVLDFFPIVAYFVIIEIFMA
>CP022041.2|ASE18281.1|505443_506262_-|KilA-N-domain-containing-protein
MTKKGEIFVKDVAIKTMTKDGIDYICITDIARQKNTAEPKDVVKNWMRQKNTLEYLGLWEKLNNPNFKGVEFDPLLAEAGSNSFTMSPTRWVELTAAIGVFTKNGAGGGTFAQRDIAFKFANWVSVEFELYLVMEFQRLKAKEQELIGWTAKRELSKINYRIHTDAIKSHLIPEKVTPTQANIIYAEEADVLNVAMFGMTARQWRESNPDLKGNIRDYASVNELICLANMENINAVLINDDIPQGERLVRLNQIAIHQMQILERNSNRNLLR
>CP022041.2|ASE18280.1|503476_505174_-|energy-dependent-translational-throttle-protein-EttA
MATVDDKKIIFSMVGVSKIIPQNQKQILKNIYLSFFYGAKIGIIGLNGAGKSTLMKIIAGLVEPTQGEVVWSPGYSVGYLPQDPPLDEAKTVKENVMEGVQHIYDALKEYDDINVKFGLEEYYSDADKMDKLMQRQAELQDIIDATDAWNIDSRLERAMDALRCPKGDLPVTNLSGGERRRVALCRLLLQKPDVLLLDEPTNHLDAESIDWLEQHLQQYEGTVIAVTHDRYFLDDVSEWILELDRGEGIPWKGNYSSWLDQKTKRMEQEEKSASKRRKTLERELEWVRMAPKARQAKGKARLNSYEQMLNEEQKQREEKLEIFIPNGPRLGNKVIEAQHVKKAFGEKVLFNDLNFMLPPNGIVGVIGPNGAGKTTLFRLIMGLEQADGGTFEVGETVKLAYVDQQHKDIDPNKTVYDVVSQGNETIRMGGRDINSRAYLSRFNFSGTDQSKLCSVLSGGERNRLQLAMALKQEGNVLLLDEPTNDIDVNTLRALEEGLEAFAGCAVVISHDRWFLDRICTHILAFEGNGEVVYFEGGFSDYEINKARRLGNEEIKKGRYRKLMEE
>CP022041.2|ASE18279.1|502367_503213_-|hypothetical-protein
MFVLFFLCFSIYGKAQTAPKKLTAPSPERFQAINDSILAEGMWLYTYEKLAWRATDSLMKYNVKREEINSATAFEEGNLTWRYIFANLDKEQTVFELTLHLSNDTSFYVCSATPRKLKPTEIEQLKAKQIAPRKVIKEKGDSIFLANTSGLNWDLLPLEKGGYRLYLLHGTTKHGVIPIGDDYAFDFDKDMNILSWRRFHRSFLEQPITMNGEEITEVIHSHTPMTPYFTTTDIANYMLYGCDLYGIKRFSVLSTAFADTSYLTTFDVEKMKLTSTVYTVK
>CP022041.2|ASE18278.1|501130_501901_-|NYN-domain-containing-protein
MEKKLGTYLLILYFCSIKSIALLSCRVSATSEWLFLFNLHTMPKRVTFYFDGFNFYFALKRKKKISPEWKDFYWLDLVAFCESFLGPDQVLEKVIYFTASPLSPQKNSRQSAFLNANRILHSDKFEVIRGKYMSKQIECPYCKYSISKPEEKRTDVNISVRMMADCVQDKTDVIVLISADTDLIPPLNFIHTNYPNKKVKVFFPPGSHALELHNHLRTFHSKWVFLEKNERRFRNAVMPHTITVGNQSVSIPEKWK
>CP022041.2|ASE18277.1|497629_500824_+|hypothetical-protein
MLFERFLRNKSLMAAMALTAVMPSVAKASILSAAPTAEGENQQLKAGVYFIVNDKRQAGTDLHVYVDESGLHGKNYTSLAADYSNAFLLHAKGDKYTIQSLKDGKYVQNVNGNSVPYKTGNDAHKFQIVYQSQSSGTGKSYFNIYNDNVGGNQFCWHLDAQRNVVRWYPLTDNGRIALGPSEFRLDPVTSLSKQQVLDRLAELTKIVDPRKDLNKYYQIVSDTYGRAMREDYIVGELSTGGFVDTDYSYCWKLVKLGSGRYAFQNAVTGKYIAQQNGQTSRYYTTSEEQGNGFEFNLNESDPYVLTFEMVDAYNVGIHCAESQGYHPVGWYVNNEANKWVFKVATIDQAKLKEQQDAYKARVDLTRNVDRYATAVAKYFTNSAATEVTAATKAMTDEALKAQMTTEGVPQGLQEVVLKIKNQSWTVYPSGRNWEKQFRIADYKVYSENNYGAWARSMGIGYDYGSMTNPTGVTARDGEDLFVFLGDDIPQDATVQIELVPLGTRSAGKYHNLKKGLNIILNQGENNVFVNYIGRTFNNGKYLRDYKPMNIHIEGGKVNGYFDLTKGNTNEDWQKMQSDGLVWAKAFNMKGELVVMNMPSQACKDYTPVHMKELVEIWNSIVQREDDLMGFRAAKRDKCNNVLNATAVDHGYMYATTGGTYYNYNTLADVLNYDKMKWGNGTLWGPAHEFGHNHQQLFNTAGMTEISVNMYSNMVMFTSGRVTSRSEHCNYTDVDGQEHRGVCESAVSTYADRFANKKMWFEYGTWGTTQMYYKLYMMFHSTGLDDQFWHKCLDYLRTHRLEGQGTANCQGQNDYLLFAKACCVAANQDLSSFFEAWGHFYDVNGSVIGDYSNTTMYTTRAQWVEAKKFMQQFPKGPANNMIFIDDHIRPTPAIYPGAAPGTMREDFNGAVRVGTMGDFGSWDQFCPDSLGQGYAIIKTQSDANGRRTYTMEAKNSHVVGFKIYDSKGNLIYFANTKTFTIPKKVMEDAQNNIVIKVCGSDGSEVDPGTVPLGIKTFSAQANGGKVDVYSIYGVLVRSKVNPETALEGLPNGVYVVGGKKVVVGK
>CP022041.2|ASE18276.1|493180_496975_+|DUF5110-domain-containing-protein
MKKKKAKILLAALLLAVGETAFADGKAVSGIRQINPTTVEITYSDGGVMTVDFYGQNVFRLFRDPKGGIVRDPVSNPPARILLDNPRKNAGRLSVNATDADVAVATAEVRVRFDRNTGLMTVTDLRNGKEVIKEVKGVDFQKNRTTVTLANAAGEYFYGGGVQNGRFSHRGKRIEIVNTNSWTDGGVASPAPFYWSTGGYAAMPYTFAPGAYDFGSTDKNTVTISHDMPYLDLFLMVDTTPVSLLQDYYQLTGNPVLLPKFAFYEGHLNAYNRDYWKETTEEGKGILFEDGKRYVESQKDNGGIKESLNGEKQNYQFSARAVIDRYKKDDMPLGWILPNDGYGAGYGQTTTLDGNIANLKSLGDYARKNGVEIGLWTQSNLHPVDSIPALLQRDIVKEVRDAGVRVLKTDVAWVGAGYSFGLNGIADVANIMPYYGSDARPFIITLDGWAGTQRYGGVWSGDQTGGEWEYIRFHIPTYIGSGLSGMGNITSDMDGIFGGKNLPVNIRDFQWKTFTPMQLNMDGWGSNPKYPQALGEPATSINRSYLKLKSILLPYTYSCAHEAVTGKPLMRAMFLDDSNDYTHSSATRYQYMYGPSFLVAPVYQNTAADKEGNDVRNGIYLPKGTWYDYFTGATYEGGCILNDYFAPIWKLPVLVKSGAIIPMVNPNNNPSEIDKNRRVFELYPDGKTEFTLYDDDGTTQKYLANEKATTRITSDLNDKQVLTVSIDKTEGSFDGMVKNQSTTFYLNTNAKPKKLTAVIGGKKIRLTEAEQGDNTWQYVQASNINRFSTANSEMERLLVTKNAQIIVRLSSCDITKEAVELRVEGFVRLNKSNETLRKKGALTAPELLEADIQSYSVTPKWKPVQNADYYEIAFNGQTYTTIRHNSLLFDDLQPATDYDFKVRAVNSEGASEWTPLHVKTAVNPLEYAIQGLTATSTARDMEGFEIHRLVDFSTTGDIWHTYYYTKAVPFDFTVDLHSTNTLDKLQYVPRANGGNGTITKCDIAVSKDGRNWTEIGPQQWARDGRTKEVTLSTHPVARYVKVSVKEAVGNFGSGREFYVFKVPGTKTILPGDINLDGKVDENDFTSYMNYTGLKKGDADFDGYISGGDINGNGLIDAYDISNVAMHLEDGWNDDDVAPVGGKVYYEYNRKSYAAGDDVIIKVKGKDLQSVNAFNLIFPYSPKELQFVKVETDPSMVMRNLTYDRHHSDGSQVLYPTFVNVGDHHTINGDADLLVIRMKALKPFTVKNTTAKGLLVDKQLREVEL
>CP022041.2|ASE18275.1|491727_492381_-|rubrerythrin
MKKKFICTVCGYIHEGTEAPAECPVCHAKAAKFKEFNPEALKGTKTEQNLKNAFAGESQAHTKYLYYASKAKKDGYEQIAGFFEETARNEKEHAKIWFKFLHEGDIPTTTQNLADAAAGENYEWTDMYEQMAKDAMEEGFPELAVKFRSVGKVEKHHEERYRKLLKNIEDSVVFSREGDCIWQCRNCGHIVIGKKAPAVCPVCNHPQSFFQVEESNY
>CP022041.2|ASE18274.1|489890_490322_-|hypothetical-protein
MNTLKISIITCFSILYSLTSFAEVKSNVSIEIGSFDSIPSEIDGGCCVFYKYPNKMRNKSYIMVNDLATTAYMMINRHLEEFTLVSNQKDIFWYKNKRFTLKVTINHTQSKGDNECYKVKGILIVEDRNKNQRKLSFCGNCSW
>CP022041.2|ASE18273.1|488952_489396_+|hypothetical-protein
MKNGDKIEFAIVGMQEDSYKVNYDIDFSKLNQEELEFQIEQRINVSAEPENIIISMRVHLMNGAEEIAMQGVRAIFKVKPFNSFVNDMQEDDLKVSNPALIDTFISVCIGAIRGMLVKNLKGTPLDNVVLPLIPMNVIRANSTKRTK
>CP022041.2|ASE18283.1|507552_507756_+|hypothetical-protein
MKKSYVKPCSTCVIMAVEQAMLAGSKGLRVTNQNLERVDHTIIGSSTPSTPSAGGNAKENPFQYDEE
>CP022041.2|ASE18284.1|507783_509490_+|hypothetical-protein
MNFKKIYGLILGVIVAGLTSCSSDLNNEEKAPVGPNETAVRSLSIATGDAKTRSEVKIDADNKWVTGDRFMAFNRTFTGSSSESRYGVLTASSTGTRTTLDGVIACKDNDELGIFYPGSYVTGFDQGKMPVVMTASYINDNKGQDGSKENLKYFDYSYGKGKVTVNGASASGSVDMKKLYSVLELDFTAGGVKLTNIKKLVLSNVLTEAVYNIQSNQLESLETGKIEVNSPVALEKVYVAILPQNHFSPTFEVYTTDNKSYRFAVSTPNFNLVAAKVYPFTVQVKEFTPNPPYIEIGGVKWGKYNLQYSTGTKVNGWVDGYHLAENPWDYYMYTPSKITEPLSDLQMSLPSYNPNDVKFDHFRWGDIEYAYDYTKTGQFWTERRDIQGVISSDKKHGDLAAYASNNKWKLPSATDFNNLMKATAEYLGYFIDDNGNKVYGVLFDPNVAEGLKGKVLDKNNKVLGSSNTAAIINAGKNLRQFVKSDFDNALFFPMAGIYYTYTGAIDKPGSQGGYWTSTSNPSNNNAAAFMPQMMSNSLGVYQGFSGTTQKALINKNNMHSIRPIYVGQ
>CP022041.2|ASE18285.1|510145_513265_+|TonB-dependent-receptor
MSNFMKVSQSRRKHPPFVSGRLAFSFALGLMAFAPSPVLANVDANTSMSVQQQKQSINGVVKDANGDPVIGASILANGTPVGVTDMDGRFSVSVAPGTELKISYVGFATQSVMVRSGVTNYNITLKDENSALSEVVVVGYGTQKKANLSGSVAQLDSKALENRPISNVSSGLQGLLPGITVTGADGAPGLDNGSILVRGVGTLNSASPYILIDGVEAGTLNSLDPEDIASISVLKDASSAAIYGSKASNGVILVTTKRGQNGAPKVSYSGYFGIQNATALMERMNSADAAYYYNKALERSGKAARFSDEAIKKFRDGSDPYNYPNTDWYDLAFKTAWQNRHSVNITGGNEYVKYLASAGYLKQSSILPNAGREQFNGRANLDMVLSKRITAHLNLAYIQNNYRDASSAYAGGSSDQIIRQLNIIAPWIVYKYEDGTYGTVSDGNPMAWLESGMTVNRNNRNFTGMIGLDYQILKDLKLTLQGAYVDASQRYSYFQKFIQYNPNKASDPNKLEIAHYDWHRTTFDAFLNYDKSFAKHNFKAMLGWHTERYKYLPDWMYRKNFPNNELTDMNAGDASTQQNAGNTRELSMVSYFGRLNYDYAGRYLFEANFRSDASSRFAEAHRWGFFPSFSAAWRISEEPFMESSKSWLNNLKLRASWGQLGNQDALNDYYPWMNTYNLNAKYPFGGQLTPGYYQGSYHLETISWERSTTWGVGLDFTLFGGLTGSLDYYNRKTTGIIMNVSAPAEFALGAYKDNIGALRNQGVELSLAYAKQLNKDWTINVGANFAYNKNKILNLGEGTEYIGSGNRRTAVGQQYNSFFMYKATGKFFNSQQEADDYTAKYGNPFGRKFMAGDLIYEDTNGDDKLDSNDRIYTKHTDIPAITYGFNLGATWKNIDLSMIWQGVGAVSHIYNREVLGEFSGDASHPSTLWKDSWTDDNHNAKLPRVFETGNSPSDMTRAMSTFWLWNTAYLRLKTLQLGYTLPKSALKAIGLEKVRIYYAGENLLTFDALPFNIDPEVTSERGSSYPLLRSHSIGINITF
>CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKTVRTYILAGVAAFALTSCNDYLTTVPKDAMSPSTTWKTGDDAEKFLVGCYDGWEDGGALLYWDAGSDFAYNNFPWEGFTNIGNGSLSPSSPGWSFYDYTIIGRCNTFLENVDKCVFSSDAVKKDLVAQVKAIRAYNYFRMGFLYGGVPIVKPFTSAQEARVPRNTEQEVKDLVFKDLDEAIADINTSPAARGRIAKGAALAMKMRAALYWGDYQKAKDAAQAIIDLGKYELDPDYTNLFKLAGVDSKEIILAVQYKSGTRPLGTIGQLYNNGDGGWSSVVPTQKCVDNYEMSNGMTITEAGSGYDATHPFHGRDPRMAMTILYPGCDWEGTIFNTLDENVNGKKNPNYPTNAANSSKTALTWRKYLDPKTQYADVWDTEACPIVFRYAEVLLTWAEAENELNGPSANVYAMIDKVRTRVGMPAVDQSKYNTKDKLRELIRRERGSEFAGEGLRRADILRWTSNGKMVAETVLNGPLNRITGTINTSATDPTMRAVVSGSSKVEDRTFQTFNRYLPIPQWNISDNPKLEQNPGYAK
>CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein
MKKIITLLVSVLLATSSFAIPAMRMWRSFKQADGTILKVMTVGDEHFNYALTEDNIPVLPHNGSYYYARIEDNQLVPSSVLAHDKALRKGKEELVAAAIQQVRQLQKQHEMHVNSKPFGEGLGMTWEGKKKGLVILVEFEDVAFKDPKNVLTLKPREKDVKTLYENMLNKVGYTNDNGAIGSVHDYFLDQSNGKFDLTFDVVGPVKLKHPHQFYGERTANMNDANAPQMIIDACNAIQGQVDFSKYDWDDDGEVEQVYVIYAGEGEATGGESSTIWPHKYSLTDAGLDALTFNGQTINTYACSNEIIRAKVNEKSRIYYSGIGTICHEFSHCLGLPDFYDTRGGSNIGSGRYDLMCGGSYNGGPESLINVYGGTGIGTVPAGYDAYEKAYMGWLKPITLGDEAVEVKNMKGLAEGGDAYFLYNPDTKNEYYIFENRTPHRWDAELPGHGLMVFHVDFDAYSWRMNNLNAASAQRHPRFTIVSADGRLDHDTQNSDPFPTDLNNSLTKSTDPRLSFYTNYNVSSQAGVKQIVRNNDNTISFHFTPLKAATGINNLSADHEQLAETYTLSGVKVADNQNLHNQIVIVKGKKVRK
>CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase
MEKKQYVEVRLRAMEPEDLDMLYHIENDRSLWNISATNVPYSRYALHNYIADAKNDIYIDGQLRMMIENREQEIVGVIDLVNFDPKHQRAEMGIIIMKPFRQKGYAKAAISALIDYTRNGLHLKQIYAVVDVDNEVSIRCLSSIGFTNGSILKEWLYCDGQYKDARVMQLFI
>CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein
MKLSVVIVNYNVKYYLQQCLESLQRALKGVEAEVFVVDNHSHDGSVAYLRSRFPDVHFIASAHNLGFAGGNNIAIRQSKGEYVLLLNPDTVVGEEVIHASIDFMDSHLTAGGHGVQMLTHCGERALESRRGLPSPMVSFYKMVGLCKHFPQSGRFAHYYMGSLSWDVPGKIEVISGAYCFLRRTALDKVGLLDEDFFMYGEDVDLSYRLLKGGFENWYLPVRILHYKGESTQKSSFRYVHVFYDAMLIFFRKHYGGMNVLWRLPIKTAIYVKAFGSLIGTTIRATRKKLGFRTSKAKSFPHYIFVAGEDVMGKCQRLATDNALVAEYRVADKDSLQHMHADLLKEFGGKSRAYCIVYDTDLFSYQDILNVFAEQPKQNIHIGFYHRKENRVVTMMEVIGD
>CP022041.2|ASE18291.1|520656_521109_-|hypothetical-protein
MDKTRKILLIEFFGSCLITLLIIAVYELELILPGAWADVESSNMVTVQFLMQLLTLATIPLALFLFKIGYVHSDLHTDESHVSRKLLFWGSVRIMMLCVPMILNTFFYYAFGDSVSFFYLAVILALSLFFVFPNKKRCEHECSMDNSEQA
>CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR
MQQYPSQLLERAVEAFSQLPGVGRKTALRLVLHLLRQSTEDVDSFADAVIRVKHDVKYCKVCHNISDNEVCSICSDPRRDASVVCVVENIQDVMAIENTQQFHGLYHVLGGIISPMDGIGPHDLEIESLVERVEEGTVKEIILALASTMEGDTTNFYISRKLKDTGVKLSVIARGISVGDELEYTDEVTLGRSILNRTPFES
>CP022041.2|ASE18293.1|521908_522388_-|hypothetical-protein
MLLVAAMVVSISASAQFQEGKGYLGASLTGLDLHYNGHDGMNIGVQAKAGYFPWDNLMVLATFDAVHNGSEAVADHISVGVGGRYYITQNGLYLGAGVKLLHANHNYNDLMPGVEVGYAFFINRSVTIEPALYYDQSFKTHNYSTVGLKVGLGIYLFDD

Crispr_ID: CP022041_7

• CRISPR_ID: CP022041_7
• CRISPR_location: 509810-509892
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_7

Consensus_repeat	Method
ACTCCCCTCCCTATGGGGGAGGGG	CRISPRCasFinder

spacers of CP022041_7

>7.1|509834|35|CP022041|CRISPRCasFinder
ACGGGGGGTGGGGCCAGTTGCTTTTGTTACATTTT

CRISPR arrays and Neighbor proteins around CP022041_7

CRISPR arrays

The CRISPR arrays of CP022041_7

>merge|CP022041|7|509810-509892|CRISPRCasFinder
ACTCCCCTCCCTATGGGGGAGGGGACGGGGGGTGGGGCCAGTTGCTTTTGTTACATTTTACTCCCCTCCCTATGGGGGAGGGG

>CP022041|7|6|509810-509892|CRISPRCasFinder
ACTCCCCTCCCTATGGGGGAGGGG	ACGGGGGGTGGGGCCAGTTGCTTTTGTTACATTTT
ACTCCCCTCCCTATGGGGGAGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18283.1|507552_507756_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|224137
CP022041.2|ASE18280.1|503476_505174_-|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl|CDD|236992
CP022041.2|ASE18906.1|523116_523323_-|peptidase	unknown	unknown	unknown
CP022041.2|ASE18279.1|502367_503213_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18285.1|510145_513265_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|274948
CP022041.2|ASE18281.1|505443_506262_-|KilA-N-domain-containing-protein	unknown	unknown	gnl|CDD|367917
CP022041.2|ASE18277.1|497629_500824_+|hypothetical-protein	unknown	unknown	gnl|CDD|379166
CP022041.2|ASE18275.1|491727_492381_-|rubrerythrin	unknown	unknown	gnl|CDD|153100
CP022041.2|ASE18282.1|506532_506802_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl|CDD|274507
CP022041.2|ASE18284.1|507783_509490_+|hypothetical-protein	unknown	unknown	gnl|CDD|372499
CP022041.2|ASE18276.1|493180_496975_+|DUF5110-domain-containing-protein	unknown	unknown	gnl|CDD|269882
CP022041.2|ASE18278.1|501130_501901_-|NYN-domain-containing-protein	unknown	unknown	gnl|CDD|350289
CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|369630
CP022041.2|ASE18291.1|520656_521109_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase	unknown	unknown	gnl|CDD|379112
CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR	unknown	unknown	gnl|CDD|234616
CP022041.2|ASE18294.1|522803_523061_-|acyl-phosphate-glycerol-3-phosphate-acyltransferase	unknown	unknown	unknown
CP022041.2|ASE18293.1|521908_522388_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein	gnl|CDD|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	6.12833e-47
CP022041.2|ASE18280.1|503476_505174_-|energy-dependent-translational-throttle-protein-EttA	gnl|CDD|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
CP022041.2|ASE18285.1|510145_513265_+|TonB-dependent-receptor	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
CP022041.2|ASE18281.1|505443_506262_-|KilA-N-domain-containing-protein	gnl|CDD|367917	pfam04383, KilA-N, KilA-N domain. The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.	2.07193e-11
CP022041.2|ASE18277.1|497629_500824_+|hypothetical-protein	gnl|CDD|379166	pfam13402, Peptidase_M60, Peptidase M60, enhancin and enhancin-like. This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonisation of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.	1.46764e-33
CP022041.2|ASE18275.1|491727_492381_-|rubrerythrin	gnl|CDD|153100	cd01041, Rubrerythrin, Rubrerythrin, ferritin-like diiron-binding domain. Rubrerythrin domain is a nonheme iron binding domain found in many air-sensitive bacteria and archaea and member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The homodimeric rubrerythrin protein contains a binuclear metal center located within a four helix bundle. Many, but not all, rubrerythrin proteins have a second domain with a rubredoxin-like hexacoordinated iron center. Rubrerythrin is thought to reduce hydrogen peroxide as part of an oxidative stress protection system but its function is still poorly understood.	2.66247e-58
CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein	gnl|CDD|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	2.71626e-55
CP022041.2|ASE18284.1|507783_509490_+|hypothetical-protein	gnl|CDD|372499	pfam13149, Mfa_like_1, Fimbrillin-like. A family of putative fimbrillin proteins found by clustering human gut metagenomic sequences. Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.	2.05988e-05
CP022041.2|ASE18276.1|493180_496975_+|DUF5110-domain-containing-protein	gnl|CDD|269882	cd06596, GH31_CPE1046, Clostridium CPE1046-like. CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type C domain in addition to the GH31 domain. Enzymes of the GH31 family possess a wide range of different hydrolytic activities including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase, 3-alpha-isomaltosyltransferase and alpha-1,4-glucan lyase. All GH31 enzymes cleave a terminal carbohydrate moiety from a substrate that varies considerably in size, depending on the enzyme, and may be either a starch or a glycoprotein.	0
CP022041.2|ASE18278.1|501130_501901_-|NYN-domain-containing-protein	gnl|CDD|350289	cd18722, PIN_NicB-like, LabA-like PIN domain of Pseudomonas putida S16 NicB and related proteins. Curiously NicB from Pseudomonas putida S16 is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine. This subfamily also includes the uncharacterized CPP15 (plasmid) protein from Campylobacter jejuni. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.16447e-25
CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	3.91272e-58
CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.39499e-24
CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR	gnl|CDD|234616	PRK00076, recR, recombination protein RecR; Reviewed.	6.95636e-114

Protein sequences

>CP022041.2|ASE18284.1|507783_509490_+|hypothetical-protein
MNFKKIYGLILGVIVAGLTSCSSDLNNEEKAPVGPNETAVRSLSIATGDAKTRSEVKIDADNKWVTGDRFMAFNRTFTGSSSESRYGVLTASSTGTRTTLDGVIACKDNDELGIFYPGSYVTGFDQGKMPVVMTASYINDNKGQDGSKENLKYFDYSYGKGKVTVNGASASGSVDMKKLYSVLELDFTAGGVKLTNIKKLVLSNVLTEAVYNIQSNQLESLETGKIEVNSPVALEKVYVAILPQNHFSPTFEVYTTDNKSYRFAVSTPNFNLVAAKVYPFTVQVKEFTPNPPYIEIGGVKWGKYNLQYSTGTKVNGWVDGYHLAENPWDYYMYTPSKITEPLSDLQMSLPSYNPNDVKFDHFRWGDIEYAYDYTKTGQFWTERRDIQGVISSDKKHGDLAAYASNNKWKLPSATDFNNLMKATAEYLGYFIDDNGNKVYGVLFDPNVAEGLKGKVLDKNNKVLGSSNTAAIINAGKNLRQFVKSDFDNALFFPMAGIYYTYTGAIDKPGSQGGYWTSTSNPSNNNAAAFMPQMMSNSLGVYQGFSGTTQKALINKNNMHSIRPIYVGQ
>CP022041.2|ASE18283.1|507552_507756_+|hypothetical-protein
MKKSYVKPCSTCVIMAVEQAMLAGSKGLRVTNQNLERVDHTIIGSSTPSTPSAGGNAKENPFQYDEE
>CP022041.2|ASE18282.1|506532_506802_+|hypothetical-protein
MEESPSAYRWFGYMFVWMLACLLILDKGVSSELFLFILLLVAIVLNAYCAYKFALGKGTFLAILAFVVAMVLDFFPIVAYFVIIEIFMA
>CP022041.2|ASE18281.1|505443_506262_-|KilA-N-domain-containing-protein
MTKKGEIFVKDVAIKTMTKDGIDYICITDIARQKNTAEPKDVVKNWMRQKNTLEYLGLWEKLNNPNFKGVEFDPLLAEAGSNSFTMSPTRWVELTAAIGVFTKNGAGGGTFAQRDIAFKFANWVSVEFELYLVMEFQRLKAKEQELIGWTAKRELSKINYRIHTDAIKSHLIPEKVTPTQANIIYAEEADVLNVAMFGMTARQWRESNPDLKGNIRDYASVNELICLANMENINAVLINDDIPQGERLVRLNQIAIHQMQILERNSNRNLLR
>CP022041.2|ASE18280.1|503476_505174_-|energy-dependent-translational-throttle-protein-EttA
MATVDDKKIIFSMVGVSKIIPQNQKQILKNIYLSFFYGAKIGIIGLNGAGKSTLMKIIAGLVEPTQGEVVWSPGYSVGYLPQDPPLDEAKTVKENVMEGVQHIYDALKEYDDINVKFGLEEYYSDADKMDKLMQRQAELQDIIDATDAWNIDSRLERAMDALRCPKGDLPVTNLSGGERRRVALCRLLLQKPDVLLLDEPTNHLDAESIDWLEQHLQQYEGTVIAVTHDRYFLDDVSEWILELDRGEGIPWKGNYSSWLDQKTKRMEQEEKSASKRRKTLERELEWVRMAPKARQAKGKARLNSYEQMLNEEQKQREEKLEIFIPNGPRLGNKVIEAQHVKKAFGEKVLFNDLNFMLPPNGIVGVIGPNGAGKTTLFRLIMGLEQADGGTFEVGETVKLAYVDQQHKDIDPNKTVYDVVSQGNETIRMGGRDINSRAYLSRFNFSGTDQSKLCSVLSGGERNRLQLAMALKQEGNVLLLDEPTNDIDVNTLRALEEGLEAFAGCAVVISHDRWFLDRICTHILAFEGNGEVVYFEGGFSDYEINKARRLGNEEIKKGRYRKLMEE
>CP022041.2|ASE18279.1|502367_503213_-|hypothetical-protein
MFVLFFLCFSIYGKAQTAPKKLTAPSPERFQAINDSILAEGMWLYTYEKLAWRATDSLMKYNVKREEINSATAFEEGNLTWRYIFANLDKEQTVFELTLHLSNDTSFYVCSATPRKLKPTEIEQLKAKQIAPRKVIKEKGDSIFLANTSGLNWDLLPLEKGGYRLYLLHGTTKHGVIPIGDDYAFDFDKDMNILSWRRFHRSFLEQPITMNGEEITEVIHSHTPMTPYFTTTDIANYMLYGCDLYGIKRFSVLSTAFADTSYLTTFDVEKMKLTSTVYTVK
>CP022041.2|ASE18278.1|501130_501901_-|NYN-domain-containing-protein
MEKKLGTYLLILYFCSIKSIALLSCRVSATSEWLFLFNLHTMPKRVTFYFDGFNFYFALKRKKKISPEWKDFYWLDLVAFCESFLGPDQVLEKVIYFTASPLSPQKNSRQSAFLNANRILHSDKFEVIRGKYMSKQIECPYCKYSISKPEEKRTDVNISVRMMADCVQDKTDVIVLISADTDLIPPLNFIHTNYPNKKVKVFFPPGSHALELHNHLRTFHSKWVFLEKNERRFRNAVMPHTITVGNQSVSIPEKWK
>CP022041.2|ASE18277.1|497629_500824_+|hypothetical-protein
MLFERFLRNKSLMAAMALTAVMPSVAKASILSAAPTAEGENQQLKAGVYFIVNDKRQAGTDLHVYVDESGLHGKNYTSLAADYSNAFLLHAKGDKYTIQSLKDGKYVQNVNGNSVPYKTGNDAHKFQIVYQSQSSGTGKSYFNIYNDNVGGNQFCWHLDAQRNVVRWYPLTDNGRIALGPSEFRLDPVTSLSKQQVLDRLAELTKIVDPRKDLNKYYQIVSDTYGRAMREDYIVGELSTGGFVDTDYSYCWKLVKLGSGRYAFQNAVTGKYIAQQNGQTSRYYTTSEEQGNGFEFNLNESDPYVLTFEMVDAYNVGIHCAESQGYHPVGWYVNNEANKWVFKVATIDQAKLKEQQDAYKARVDLTRNVDRYATAVAKYFTNSAATEVTAATKAMTDEALKAQMTTEGVPQGLQEVVLKIKNQSWTVYPSGRNWEKQFRIADYKVYSENNYGAWARSMGIGYDYGSMTNPTGVTARDGEDLFVFLGDDIPQDATVQIELVPLGTRSAGKYHNLKKGLNIILNQGENNVFVNYIGRTFNNGKYLRDYKPMNIHIEGGKVNGYFDLTKGNTNEDWQKMQSDGLVWAKAFNMKGELVVMNMPSQACKDYTPVHMKELVEIWNSIVQREDDLMGFRAAKRDKCNNVLNATAVDHGYMYATTGGTYYNYNTLADVLNYDKMKWGNGTLWGPAHEFGHNHQQLFNTAGMTEISVNMYSNMVMFTSGRVTSRSEHCNYTDVDGQEHRGVCESAVSTYADRFANKKMWFEYGTWGTTQMYYKLYMMFHSTGLDDQFWHKCLDYLRTHRLEGQGTANCQGQNDYLLFAKACCVAANQDLSSFFEAWGHFYDVNGSVIGDYSNTTMYTTRAQWVEAKKFMQQFPKGPANNMIFIDDHIRPTPAIYPGAAPGTMREDFNGAVRVGTMGDFGSWDQFCPDSLGQGYAIIKTQSDANGRRTYTMEAKNSHVVGFKIYDSKGNLIYFANTKTFTIPKKVMEDAQNNIVIKVCGSDGSEVDPGTVPLGIKTFSAQANGGKVDVYSIYGVLVRSKVNPETALEGLPNGVYVVGGKKVVVGK
>CP022041.2|ASE18276.1|493180_496975_+|DUF5110-domain-containing-protein
MKKKKAKILLAALLLAVGETAFADGKAVSGIRQINPTTVEITYSDGGVMTVDFYGQNVFRLFRDPKGGIVRDPVSNPPARILLDNPRKNAGRLSVNATDADVAVATAEVRVRFDRNTGLMTVTDLRNGKEVIKEVKGVDFQKNRTTVTLANAAGEYFYGGGVQNGRFSHRGKRIEIVNTNSWTDGGVASPAPFYWSTGGYAAMPYTFAPGAYDFGSTDKNTVTISHDMPYLDLFLMVDTTPVSLLQDYYQLTGNPVLLPKFAFYEGHLNAYNRDYWKETTEEGKGILFEDGKRYVESQKDNGGIKESLNGEKQNYQFSARAVIDRYKKDDMPLGWILPNDGYGAGYGQTTTLDGNIANLKSLGDYARKNGVEIGLWTQSNLHPVDSIPALLQRDIVKEVRDAGVRVLKTDVAWVGAGYSFGLNGIADVANIMPYYGSDARPFIITLDGWAGTQRYGGVWSGDQTGGEWEYIRFHIPTYIGSGLSGMGNITSDMDGIFGGKNLPVNIRDFQWKTFTPMQLNMDGWGSNPKYPQALGEPATSINRSYLKLKSILLPYTYSCAHEAVTGKPLMRAMFLDDSNDYTHSSATRYQYMYGPSFLVAPVYQNTAADKEGNDVRNGIYLPKGTWYDYFTGATYEGGCILNDYFAPIWKLPVLVKSGAIIPMVNPNNNPSEIDKNRRVFELYPDGKTEFTLYDDDGTTQKYLANEKATTRITSDLNDKQVLTVSIDKTEGSFDGMVKNQSTTFYLNTNAKPKKLTAVIGGKKIRLTEAEQGDNTWQYVQASNINRFSTANSEMERLLVTKNAQIIVRLSSCDITKEAVELRVEGFVRLNKSNETLRKKGALTAPELLEADIQSYSVTPKWKPVQNADYYEIAFNGQTYTTIRHNSLLFDDLQPATDYDFKVRAVNSEGASEWTPLHVKTAVNPLEYAIQGLTATSTARDMEGFEIHRLVDFSTTGDIWHTYYYTKAVPFDFTVDLHSTNTLDKLQYVPRANGGNGTITKCDIAVSKDGRNWTEIGPQQWARDGRTKEVTLSTHPVARYVKVSVKEAVGNFGSGREFYVFKVPGTKTILPGDINLDGKVDENDFTSYMNYTGLKKGDADFDGYISGGDINGNGLIDAYDISNVAMHLEDGWNDDDVAPVGGKVYYEYNRKSYAAGDDVIIKVKGKDLQSVNAFNLIFPYSPKELQFVKVETDPSMVMRNLTYDRHHSDGSQVLYPTFVNVGDHHTINGDADLLVIRMKALKPFTVKNTTAKGLLVDKQLREVEL
>CP022041.2|ASE18275.1|491727_492381_-|rubrerythrin
MKKKFICTVCGYIHEGTEAPAECPVCHAKAAKFKEFNPEALKGTKTEQNLKNAFAGESQAHTKYLYYASKAKKDGYEQIAGFFEETARNEKEHAKIWFKFLHEGDIPTTTQNLADAAAGENYEWTDMYEQMAKDAMEEGFPELAVKFRSVGKVEKHHEERYRKLLKNIEDSVVFSREGDCIWQCRNCGHIVIGKKAPAVCPVCNHPQSFFQVEESNY
>CP022041.2|ASE18285.1|510145_513265_+|TonB-dependent-receptor
MSNFMKVSQSRRKHPPFVSGRLAFSFALGLMAFAPSPVLANVDANTSMSVQQQKQSINGVVKDANGDPVIGASILANGTPVGVTDMDGRFSVSVAPGTELKISYVGFATQSVMVRSGVTNYNITLKDENSALSEVVVVGYGTQKKANLSGSVAQLDSKALENRPISNVSSGLQGLLPGITVTGADGAPGLDNGSILVRGVGTLNSASPYILIDGVEAGTLNSLDPEDIASISVLKDASSAAIYGSKASNGVILVTTKRGQNGAPKVSYSGYFGIQNATALMERMNSADAAYYYNKALERSGKAARFSDEAIKKFRDGSDPYNYPNTDWYDLAFKTAWQNRHSVNITGGNEYVKYLASAGYLKQSSILPNAGREQFNGRANLDMVLSKRITAHLNLAYIQNNYRDASSAYAGGSSDQIIRQLNIIAPWIVYKYEDGTYGTVSDGNPMAWLESGMTVNRNNRNFTGMIGLDYQILKDLKLTLQGAYVDASQRYSYFQKFIQYNPNKASDPNKLEIAHYDWHRTTFDAFLNYDKSFAKHNFKAMLGWHTERYKYLPDWMYRKNFPNNELTDMNAGDASTQQNAGNTRELSMVSYFGRLNYDYAGRYLFEANFRSDASSRFAEAHRWGFFPSFSAAWRISEEPFMESSKSWLNNLKLRASWGQLGNQDALNDYYPWMNTYNLNAKYPFGGQLTPGYYQGSYHLETISWERSTTWGVGLDFTLFGGLTGSLDYYNRKTTGIIMNVSAPAEFALGAYKDNIGALRNQGVELSLAYAKQLNKDWTINVGANFAYNKNKILNLGEGTEYIGSGNRRTAVGQQYNSFFMYKATGKFFNSQQEADDYTAKYGNPFGRKFMAGDLIYEDTNGDDKLDSNDRIYTKHTDIPAITYGFNLGATWKNIDLSMIWQGVGAVSHIYNREVLGEFSGDASHPSTLWKDSWTDDNHNAKLPRVFETGNSPSDMTRAMSTFWLWNTAYLRLKTLQLGYTLPKSALKAIGLEKVRIYYAGENLLTFDALPFNIDPEVTSERGSSYPLLRSHSIGINITF
>CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKTVRTYILAGVAAFALTSCNDYLTTVPKDAMSPSTTWKTGDDAEKFLVGCYDGWEDGGALLYWDAGSDFAYNNFPWEGFTNIGNGSLSPSSPGWSFYDYTIIGRCNTFLENVDKCVFSSDAVKKDLVAQVKAIRAYNYFRMGFLYGGVPIVKPFTSAQEARVPRNTEQEVKDLVFKDLDEAIADINTSPAARGRIAKGAALAMKMRAALYWGDYQKAKDAAQAIIDLGKYELDPDYTNLFKLAGVDSKEIILAVQYKSGTRPLGTIGQLYNNGDGGWSSVVPTQKCVDNYEMSNGMTITEAGSGYDATHPFHGRDPRMAMTILYPGCDWEGTIFNTLDENVNGKKNPNYPTNAANSSKTALTWRKYLDPKTQYADVWDTEACPIVFRYAEVLLTWAEAENELNGPSANVYAMIDKVRTRVGMPAVDQSKYNTKDKLRELIRRERGSEFAGEGLRRADILRWTSNGKMVAETVLNGPLNRITGTINTSATDPTMRAVVSGSSKVEDRTFQTFNRYLPIPQWNISDNPKLEQNPGYAK
>CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein
MKKIITLLVSVLLATSSFAIPAMRMWRSFKQADGTILKVMTVGDEHFNYALTEDNIPVLPHNGSYYYARIEDNQLVPSSVLAHDKALRKGKEELVAAAIQQVRQLQKQHEMHVNSKPFGEGLGMTWEGKKKGLVILVEFEDVAFKDPKNVLTLKPREKDVKTLYENMLNKVGYTNDNGAIGSVHDYFLDQSNGKFDLTFDVVGPVKLKHPHQFYGERTANMNDANAPQMIIDACNAIQGQVDFSKYDWDDDGEVEQVYVIYAGEGEATGGESSTIWPHKYSLTDAGLDALTFNGQTINTYACSNEIIRAKVNEKSRIYYSGIGTICHEFSHCLGLPDFYDTRGGSNIGSGRYDLMCGGSYNGGPESLINVYGGTGIGTVPAGYDAYEKAYMGWLKPITLGDEAVEVKNMKGLAEGGDAYFLYNPDTKNEYYIFENRTPHRWDAELPGHGLMVFHVDFDAYSWRMNNLNAASAQRHPRFTIVSADGRLDHDTQNSDPFPTDLNNSLTKSTDPRLSFYTNYNVSSQAGVKQIVRNNDNTISFHFTPLKAATGINNLSADHEQLAETYTLSGVKVADNQNLHNQIVIVKGKKVRK
>CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase
MEKKQYVEVRLRAMEPEDLDMLYHIENDRSLWNISATNVPYSRYALHNYIADAKNDIYIDGQLRMMIENREQEIVGVIDLVNFDPKHQRAEMGIIIMKPFRQKGYAKAAISALIDYTRNGLHLKQIYAVVDVDNEVSIRCLSSIGFTNGSILKEWLYCDGQYKDARVMQLFI
>CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein
MKLSVVIVNYNVKYYLQQCLESLQRALKGVEAEVFVVDNHSHDGSVAYLRSRFPDVHFIASAHNLGFAGGNNIAIRQSKGEYVLLLNPDTVVGEEVIHASIDFMDSHLTAGGHGVQMLTHCGERALESRRGLPSPMVSFYKMVGLCKHFPQSGRFAHYYMGSLSWDVPGKIEVISGAYCFLRRTALDKVGLLDEDFFMYGEDVDLSYRLLKGGFENWYLPVRILHYKGESTQKSSFRYVHVFYDAMLIFFRKHYGGMNVLWRLPIKTAIYVKAFGSLIGTTIRATRKKLGFRTSKAKSFPHYIFVAGEDVMGKCQRLATDNALVAEYRVADKDSLQHMHADLLKEFGGKSRAYCIVYDTDLFSYQDILNVFAEQPKQNIHIGFYHRKENRVVTMMEVIGD
>CP022041.2|ASE18291.1|520656_521109_-|hypothetical-protein
MDKTRKILLIEFFGSCLITLLIIAVYELELILPGAWADVESSNMVTVQFLMQLLTLATIPLALFLFKIGYVHSDLHTDESHVSRKLLFWGSVRIMMLCVPMILNTFFYYAFGDSVSFFYLAVILALSLFFVFPNKKRCEHECSMDNSEQA
>CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR
MQQYPSQLLERAVEAFSQLPGVGRKTALRLVLHLLRQSTEDVDSFADAVIRVKHDVKYCKVCHNISDNEVCSICSDPRRDASVVCVVENIQDVMAIENTQQFHGLYHVLGGIISPMDGIGPHDLEIESLVERVEEGTVKEIILALASTMEGDTTNFYISRKLKDTGVKLSVIARGISVGDELEYTDEVTLGRSILNRTPFES
>CP022041.2|ASE18293.1|521908_522388_-|hypothetical-protein
MLLVAAMVVSISASAQFQEGKGYLGASLTGLDLHYNGHDGMNIGVQAKAGYFPWDNLMVLATFDAVHNGSEAVADHISVGVGGRYYITQNGLYLGAGVKLLHANHNYNDLMPGVEVGYAFFINRSVTIEPALYYDQSFKTHNYSTVGLKVGLGIYLFDD
>CP022041.2|ASE18294.1|522803_523061_-|acyl-phosphate-glycerol-3-phosphate-acyltransferase
MKRIKIIRVLATFICHDPFAYSPIWTWDGFPPIIYTERERILPVLKEWEHKGYLTLIYDEKIAFILNVEKLPSKEKLIEESRNIK
>CP022041.2|ASE18906.1|523116_523323_-|peptidase
MSPIVDWNLLDVLNKNIRDNYERIRPILLKWQENGYIKLIEDNEIAFSFIPEKLPSKEKLIEESLNFK

Crispr_ID: CP022041_8

• CRISPR_ID: CP022041_8
• CRISPR_location: 515345-515467
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_8

Consensus_repeat	Method
GAGTGAACGAGTGGACAAGTGAACAAGTTACTTGCAAGAGAAGACAA	CRISPRCasFinder

spacers of CP022041_8

>8.1|515392|29|CP022041|CRISPRCasFinder
AGTAACAGATGAACAGGTGTTTAGTGGAC

CRISPR arrays and Neighbor proteins around CP022041_8

CRISPR arrays

The CRISPR arrays of CP022041_8

>merge|CP022041|8|515345-515467|CRISPRCasFinder
GAGTGAACGAGTGGACAAGTGAACAAGTTACTTGCAAGAGAAGACAAAGTAACAGATGAACAGGTGTTTAGTGGACGAGTGAACGAGTGGTCAAGTGAACAAGTTACTTGCAAGAGAAGACAA

>CP022041|8|7|515345-515467|CRISPRCasFinder
GAGTGAACGAGTGGACAAGTGAACAAGTTACTTGCAAGAGAAGACAA	AGTAACAGATGAACAGGTGTTTAGTGGAC
GAGTGAACGAGTGGTCAAGTGAACAAGTTACTTGCAAGAGAAGACAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18283.1|507552_507756_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|224137
CP022041.2|ASE18280.1|503476_505174_-|energy-dependent-translational-throttle-protein-EttA	unknown	unknown	gnl|CDD|236992
CP022041.2|ASE18278.1|501130_501901_-|NYN-domain-containing-protein	unknown	unknown	gnl|CDD|350289
CP022041.2|ASE18285.1|510145_513265_+|TonB-dependent-receptor	unknown	unknown	gnl|CDD|274948
CP022041.2|ASE18281.1|505443_506262_-|KilA-N-domain-containing-protein	unknown	unknown	gnl|CDD|367917
CP022041.2|ASE18277.1|497629_500824_+|hypothetical-protein	unknown	unknown	gnl|CDD|379166
CP022041.2|ASE18906.1|523116_523323_-|peptidase	unknown	unknown	unknown
CP022041.2|ASE18296.1|527410_528142_-|NADPH-dependent-oxidoreductase	unknown	unknown	gnl|CDD|380322
CP022041.2|ASE18282.1|506532_506802_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl|CDD|274507
CP022041.2|ASE18295.1|524521_526729_-|sodium-translocating-pyrophosphatase	unknown	unknown	gnl|CDD|376979
CP022041.2|ASE18284.1|507783_509490_+|hypothetical-protein	unknown	unknown	gnl|CDD|372499
CP022041.2|ASE18279.1|502367_503213_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|369630
CP022041.2|ASE18291.1|520656_521109_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase	unknown	unknown	gnl|CDD|379112
CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR	unknown	unknown	gnl|CDD|234616
CP022041.2|ASE18294.1|522803_523061_-|acyl-phosphate-glycerol-3-phosphate-acyltransferase	unknown	unknown	unknown
CP022041.2|ASE18293.1|521908_522388_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein	gnl|CDD|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	6.12833e-47
CP022041.2|ASE18280.1|503476_505174_-|energy-dependent-translational-throttle-protein-EttA	gnl|CDD|236992	PRK11819, PRK11819, putative ABC transporter ATP-binding protein; Reviewed.	0
CP022041.2|ASE18285.1|510145_513265_+|TonB-dependent-receptor	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
CP022041.2|ASE18284.1|507783_509490_+|hypothetical-protein	gnl|CDD|372499	pfam13149, Mfa_like_1, Fimbrillin-like. A family of putative fimbrillin proteins found by clustering human gut metagenomic sequences. Analysis of structural comparisons shows this family to be part of the FimbA (CL0450) superfamily of adhesin components or fimbrillins.	2.05988e-05
CP022041.2|ASE18277.1|497629_500824_+|hypothetical-protein	gnl|CDD|379166	pfam13402, Peptidase_M60, Peptidase M60, enhancin and enhancin-like. This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonisation of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.	1.46764e-33
CP022041.2|ASE18296.1|527410_528142_-|NADPH-dependent-oxidoreductase	gnl|CDD|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	3.3976e-74
CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein	gnl|CDD|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	2.71626e-55
CP022041.2|ASE18295.1|524521_526729_-|sodium-translocating-pyrophosphatase	gnl|CDD|376979	pfam03030, H_PPase, Inorganic H+ pyrophosphatase. The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists.	0
CP022041.2|ASE18281.1|505443_506262_-|KilA-N-domain-containing-protein	gnl|CDD|367917	pfam04383, KilA-N, KilA-N domain. The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.	2.07193e-11
CP022041.2|ASE18278.1|501130_501901_-|NYN-domain-containing-protein	gnl|CDD|350289	cd18722, PIN_NicB-like, LabA-like PIN domain of Pseudomonas putida S16 NicB and related proteins. Curiously NicB from Pseudomonas putida S16 is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine. This subfamily also includes the uncharacterized CPP15 (plasmid) protein from Campylobacter jejuni. This subfamily belongs to LabA-like PIN domain family which includes Synechococcus elongatus PCC 7942 LabA, human ZNF451, uncharacterized Bacillus subtilis YqxD and Escherichia coli YaiI, and the N-terminal domain of a well-conserved group of mainly bacterial proteins with no defined function, which contain a C-terminal LabA_like_C domain. Curiously, a gene labeled NicB from Pseudomonas putida S16, which is described as a putative NADH-dependent hydroxylase involved in the microbial degradation of nicotine also falls into the LabA-like PIN family. The PIN (PilT N terminus) domain belongs to a large nuclease superfamily. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members, additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	1.16447e-25
CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	3.91272e-58
CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.39499e-24
CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR	gnl|CDD|234616	PRK00076, recR, recombination protein RecR; Reviewed.	6.95636e-114

Protein sequences

>CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKTVRTYILAGVAAFALTSCNDYLTTVPKDAMSPSTTWKTGDDAEKFLVGCYDGWEDGGALLYWDAGSDFAYNNFPWEGFTNIGNGSLSPSSPGWSFYDYTIIGRCNTFLENVDKCVFSSDAVKKDLVAQVKAIRAYNYFRMGFLYGGVPIVKPFTSAQEARVPRNTEQEVKDLVFKDLDEAIADINTSPAARGRIAKGAALAMKMRAALYWGDYQKAKDAAQAIIDLGKYELDPDYTNLFKLAGVDSKEIILAVQYKSGTRPLGTIGQLYNNGDGGWSSVVPTQKCVDNYEMSNGMTITEAGSGYDATHPFHGRDPRMAMTILYPGCDWEGTIFNTLDENVNGKKNPNYPTNAANSSKTALTWRKYLDPKTQYADVWDTEACPIVFRYAEVLLTWAEAENELNGPSANVYAMIDKVRTRVGMPAVDQSKYNTKDKLRELIRRERGSEFAGEGLRRADILRWTSNGKMVAETVLNGPLNRITGTINTSATDPTMRAVVSGSSKVEDRTFQTFNRYLPIPQWNISDNPKLEQNPGYAK
>CP022041.2|ASE18285.1|510145_513265_+|TonB-dependent-receptor
MSNFMKVSQSRRKHPPFVSGRLAFSFALGLMAFAPSPVLANVDANTSMSVQQQKQSINGVVKDANGDPVIGASILANGTPVGVTDMDGRFSVSVAPGTELKISYVGFATQSVMVRSGVTNYNITLKDENSALSEVVVVGYGTQKKANLSGSVAQLDSKALENRPISNVSSGLQGLLPGITVTGADGAPGLDNGSILVRGVGTLNSASPYILIDGVEAGTLNSLDPEDIASISVLKDASSAAIYGSKASNGVILVTTKRGQNGAPKVSYSGYFGIQNATALMERMNSADAAYYYNKALERSGKAARFSDEAIKKFRDGSDPYNYPNTDWYDLAFKTAWQNRHSVNITGGNEYVKYLASAGYLKQSSILPNAGREQFNGRANLDMVLSKRITAHLNLAYIQNNYRDASSAYAGGSSDQIIRQLNIIAPWIVYKYEDGTYGTVSDGNPMAWLESGMTVNRNNRNFTGMIGLDYQILKDLKLTLQGAYVDASQRYSYFQKFIQYNPNKASDPNKLEIAHYDWHRTTFDAFLNYDKSFAKHNFKAMLGWHTERYKYLPDWMYRKNFPNNELTDMNAGDASTQQNAGNTRELSMVSYFGRLNYDYAGRYLFEANFRSDASSRFAEAHRWGFFPSFSAAWRISEEPFMESSKSWLNNLKLRASWGQLGNQDALNDYYPWMNTYNLNAKYPFGGQLTPGYYQGSYHLETISWERSTTWGVGLDFTLFGGLTGSLDYYNRKTTGIIMNVSAPAEFALGAYKDNIGALRNQGVELSLAYAKQLNKDWTINVGANFAYNKNKILNLGEGTEYIGSGNRRTAVGQQYNSFFMYKATGKFFNSQQEADDYTAKYGNPFGRKFMAGDLIYEDTNGDDKLDSNDRIYTKHTDIPAITYGFNLGATWKNIDLSMIWQGVGAVSHIYNREVLGEFSGDASHPSTLWKDSWTDDNHNAKLPRVFETGNSPSDMTRAMSTFWLWNTAYLRLKTLQLGYTLPKSALKAIGLEKVRIYYAGENLLTFDALPFNIDPEVTSERGSSYPLLRSHSIGINITF
>CP022041.2|ASE18284.1|507783_509490_+|hypothetical-protein
MNFKKIYGLILGVIVAGLTSCSSDLNNEEKAPVGPNETAVRSLSIATGDAKTRSEVKIDADNKWVTGDRFMAFNRTFTGSSSESRYGVLTASSTGTRTTLDGVIACKDNDELGIFYPGSYVTGFDQGKMPVVMTASYINDNKGQDGSKENLKYFDYSYGKGKVTVNGASASGSVDMKKLYSVLELDFTAGGVKLTNIKKLVLSNVLTEAVYNIQSNQLESLETGKIEVNSPVALEKVYVAILPQNHFSPTFEVYTTDNKSYRFAVSTPNFNLVAAKVYPFTVQVKEFTPNPPYIEIGGVKWGKYNLQYSTGTKVNGWVDGYHLAENPWDYYMYTPSKITEPLSDLQMSLPSYNPNDVKFDHFRWGDIEYAYDYTKTGQFWTERRDIQGVISSDKKHGDLAAYASNNKWKLPSATDFNNLMKATAEYLGYFIDDNGNKVYGVLFDPNVAEGLKGKVLDKNNKVLGSSNTAAIINAGKNLRQFVKSDFDNALFFPMAGIYYTYTGAIDKPGSQGGYWTSTSNPSNNNAAAFMPQMMSNSLGVYQGFSGTTQKALINKNNMHSIRPIYVGQ
>CP022041.2|ASE18283.1|507552_507756_+|hypothetical-protein
MKKSYVKPCSTCVIMAVEQAMLAGSKGLRVTNQNLERVDHTIIGSSTPSTPSAGGNAKENPFQYDEE
>CP022041.2|ASE18282.1|506532_506802_+|hypothetical-protein
MEESPSAYRWFGYMFVWMLACLLILDKGVSSELFLFILLLVAIVLNAYCAYKFALGKGTFLAILAFVVAMVLDFFPIVAYFVIIEIFMA
>CP022041.2|ASE18281.1|505443_506262_-|KilA-N-domain-containing-protein
MTKKGEIFVKDVAIKTMTKDGIDYICITDIARQKNTAEPKDVVKNWMRQKNTLEYLGLWEKLNNPNFKGVEFDPLLAEAGSNSFTMSPTRWVELTAAIGVFTKNGAGGGTFAQRDIAFKFANWVSVEFELYLVMEFQRLKAKEQELIGWTAKRELSKINYRIHTDAIKSHLIPEKVTPTQANIIYAEEADVLNVAMFGMTARQWRESNPDLKGNIRDYASVNELICLANMENINAVLINDDIPQGERLVRLNQIAIHQMQILERNSNRNLLR
>CP022041.2|ASE18280.1|503476_505174_-|energy-dependent-translational-throttle-protein-EttA
MATVDDKKIIFSMVGVSKIIPQNQKQILKNIYLSFFYGAKIGIIGLNGAGKSTLMKIIAGLVEPTQGEVVWSPGYSVGYLPQDPPLDEAKTVKENVMEGVQHIYDALKEYDDINVKFGLEEYYSDADKMDKLMQRQAELQDIIDATDAWNIDSRLERAMDALRCPKGDLPVTNLSGGERRRVALCRLLLQKPDVLLLDEPTNHLDAESIDWLEQHLQQYEGTVIAVTHDRYFLDDVSEWILELDRGEGIPWKGNYSSWLDQKTKRMEQEEKSASKRRKTLERELEWVRMAPKARQAKGKARLNSYEQMLNEEQKQREEKLEIFIPNGPRLGNKVIEAQHVKKAFGEKVLFNDLNFMLPPNGIVGVIGPNGAGKTTLFRLIMGLEQADGGTFEVGETVKLAYVDQQHKDIDPNKTVYDVVSQGNETIRMGGRDINSRAYLSRFNFSGTDQSKLCSVLSGGERNRLQLAMALKQEGNVLLLDEPTNDIDVNTLRALEEGLEAFAGCAVVISHDRWFLDRICTHILAFEGNGEVVYFEGGFSDYEINKARRLGNEEIKKGRYRKLMEE
>CP022041.2|ASE18279.1|502367_503213_-|hypothetical-protein
MFVLFFLCFSIYGKAQTAPKKLTAPSPERFQAINDSILAEGMWLYTYEKLAWRATDSLMKYNVKREEINSATAFEEGNLTWRYIFANLDKEQTVFELTLHLSNDTSFYVCSATPRKLKPTEIEQLKAKQIAPRKVIKEKGDSIFLANTSGLNWDLLPLEKGGYRLYLLHGTTKHGVIPIGDDYAFDFDKDMNILSWRRFHRSFLEQPITMNGEEITEVIHSHTPMTPYFTTTDIANYMLYGCDLYGIKRFSVLSTAFADTSYLTTFDVEKMKLTSTVYTVK
>CP022041.2|ASE18278.1|501130_501901_-|NYN-domain-containing-protein
MEKKLGTYLLILYFCSIKSIALLSCRVSATSEWLFLFNLHTMPKRVTFYFDGFNFYFALKRKKKISPEWKDFYWLDLVAFCESFLGPDQVLEKVIYFTASPLSPQKNSRQSAFLNANRILHSDKFEVIRGKYMSKQIECPYCKYSISKPEEKRTDVNISVRMMADCVQDKTDVIVLISADTDLIPPLNFIHTNYPNKKVKVFFPPGSHALELHNHLRTFHSKWVFLEKNERRFRNAVMPHTITVGNQSVSIPEKWK
>CP022041.2|ASE18277.1|497629_500824_+|hypothetical-protein
MLFERFLRNKSLMAAMALTAVMPSVAKASILSAAPTAEGENQQLKAGVYFIVNDKRQAGTDLHVYVDESGLHGKNYTSLAADYSNAFLLHAKGDKYTIQSLKDGKYVQNVNGNSVPYKTGNDAHKFQIVYQSQSSGTGKSYFNIYNDNVGGNQFCWHLDAQRNVVRWYPLTDNGRIALGPSEFRLDPVTSLSKQQVLDRLAELTKIVDPRKDLNKYYQIVSDTYGRAMREDYIVGELSTGGFVDTDYSYCWKLVKLGSGRYAFQNAVTGKYIAQQNGQTSRYYTTSEEQGNGFEFNLNESDPYVLTFEMVDAYNVGIHCAESQGYHPVGWYVNNEANKWVFKVATIDQAKLKEQQDAYKARVDLTRNVDRYATAVAKYFTNSAATEVTAATKAMTDEALKAQMTTEGVPQGLQEVVLKIKNQSWTVYPSGRNWEKQFRIADYKVYSENNYGAWARSMGIGYDYGSMTNPTGVTARDGEDLFVFLGDDIPQDATVQIELVPLGTRSAGKYHNLKKGLNIILNQGENNVFVNYIGRTFNNGKYLRDYKPMNIHIEGGKVNGYFDLTKGNTNEDWQKMQSDGLVWAKAFNMKGELVVMNMPSQACKDYTPVHMKELVEIWNSIVQREDDLMGFRAAKRDKCNNVLNATAVDHGYMYATTGGTYYNYNTLADVLNYDKMKWGNGTLWGPAHEFGHNHQQLFNTAGMTEISVNMYSNMVMFTSGRVTSRSEHCNYTDVDGQEHRGVCESAVSTYADRFANKKMWFEYGTWGTTQMYYKLYMMFHSTGLDDQFWHKCLDYLRTHRLEGQGTANCQGQNDYLLFAKACCVAANQDLSSFFEAWGHFYDVNGSVIGDYSNTTMYTTRAQWVEAKKFMQQFPKGPANNMIFIDDHIRPTPAIYPGAAPGTMREDFNGAVRVGTMGDFGSWDQFCPDSLGQGYAIIKTQSDANGRRTYTMEAKNSHVVGFKIYDSKGNLIYFANTKTFTIPKKVMEDAQNNIVIKVCGSDGSEVDPGTVPLGIKTFSAQANGGKVDVYSIYGVLVRSKVNPETALEGLPNGVYVVGGKKVVVGK
>CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein
MKKIITLLVSVLLATSSFAIPAMRMWRSFKQADGTILKVMTVGDEHFNYALTEDNIPVLPHNGSYYYARIEDNQLVPSSVLAHDKALRKGKEELVAAAIQQVRQLQKQHEMHVNSKPFGEGLGMTWEGKKKGLVILVEFEDVAFKDPKNVLTLKPREKDVKTLYENMLNKVGYTNDNGAIGSVHDYFLDQSNGKFDLTFDVVGPVKLKHPHQFYGERTANMNDANAPQMIIDACNAIQGQVDFSKYDWDDDGEVEQVYVIYAGEGEATGGESSTIWPHKYSLTDAGLDALTFNGQTINTYACSNEIIRAKVNEKSRIYYSGIGTICHEFSHCLGLPDFYDTRGGSNIGSGRYDLMCGGSYNGGPESLINVYGGTGIGTVPAGYDAYEKAYMGWLKPITLGDEAVEVKNMKGLAEGGDAYFLYNPDTKNEYYIFENRTPHRWDAELPGHGLMVFHVDFDAYSWRMNNLNAASAQRHPRFTIVSADGRLDHDTQNSDPFPTDLNNSLTKSTDPRLSFYTNYNVSSQAGVKQIVRNNDNTISFHFTPLKAATGINNLSADHEQLAETYTLSGVKVADNQNLHNQIVIVKGKKVRK
>CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase
MEKKQYVEVRLRAMEPEDLDMLYHIENDRSLWNISATNVPYSRYALHNYIADAKNDIYIDGQLRMMIENREQEIVGVIDLVNFDPKHQRAEMGIIIMKPFRQKGYAKAAISALIDYTRNGLHLKQIYAVVDVDNEVSIRCLSSIGFTNGSILKEWLYCDGQYKDARVMQLFI
>CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein
MKLSVVIVNYNVKYYLQQCLESLQRALKGVEAEVFVVDNHSHDGSVAYLRSRFPDVHFIASAHNLGFAGGNNIAIRQSKGEYVLLLNPDTVVGEEVIHASIDFMDSHLTAGGHGVQMLTHCGERALESRRGLPSPMVSFYKMVGLCKHFPQSGRFAHYYMGSLSWDVPGKIEVISGAYCFLRRTALDKVGLLDEDFFMYGEDVDLSYRLLKGGFENWYLPVRILHYKGESTQKSSFRYVHVFYDAMLIFFRKHYGGMNVLWRLPIKTAIYVKAFGSLIGTTIRATRKKLGFRTSKAKSFPHYIFVAGEDVMGKCQRLATDNALVAEYRVADKDSLQHMHADLLKEFGGKSRAYCIVYDTDLFSYQDILNVFAEQPKQNIHIGFYHRKENRVVTMMEVIGD
>CP022041.2|ASE18291.1|520656_521109_-|hypothetical-protein
MDKTRKILLIEFFGSCLITLLIIAVYELELILPGAWADVESSNMVTVQFLMQLLTLATIPLALFLFKIGYVHSDLHTDESHVSRKLLFWGSVRIMMLCVPMILNTFFYYAFGDSVSFFYLAVILALSLFFVFPNKKRCEHECSMDNSEQA
>CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR
MQQYPSQLLERAVEAFSQLPGVGRKTALRLVLHLLRQSTEDVDSFADAVIRVKHDVKYCKVCHNISDNEVCSICSDPRRDASVVCVVENIQDVMAIENTQQFHGLYHVLGGIISPMDGIGPHDLEIESLVERVEEGTVKEIILALASTMEGDTTNFYISRKLKDTGVKLSVIARGISVGDELEYTDEVTLGRSILNRTPFES
>CP022041.2|ASE18293.1|521908_522388_-|hypothetical-protein
MLLVAAMVVSISASAQFQEGKGYLGASLTGLDLHYNGHDGMNIGVQAKAGYFPWDNLMVLATFDAVHNGSEAVADHISVGVGGRYYITQNGLYLGAGVKLLHANHNYNDLMPGVEVGYAFFINRSVTIEPALYYDQSFKTHNYSTVGLKVGLGIYLFDD
>CP022041.2|ASE18294.1|522803_523061_-|acyl-phosphate-glycerol-3-phosphate-acyltransferase
MKRIKIIRVLATFICHDPFAYSPIWTWDGFPPIIYTERERILPVLKEWEHKGYLTLIYDEKIAFILNVEKLPSKEKLIEESRNIK
>CP022041.2|ASE18906.1|523116_523323_-|peptidase
MSPIVDWNLLDVLNKNIRDNYERIRPILLKWQENGYIKLIEDNEIAFSFIPEKLPSKEKLIEESLNFK
>CP022041.2|ASE18295.1|524521_526729_-|sodium-translocating-pyrophosphatase
MEHIPQVFWLIPIASVCALGMAWYFFKSMMKAEEGTPRMVEIAEYVRRGAMAYLKQQYKVVLIVFVVLAIVFAIMAYGFNAQNEWVPFAFLTGGFFSGLAGFFGMKTATYASARTANAARNGLNDGLKIAFRSGAVMGLVVVGLGLLDIAIWFIVLTWFYSDKMTTSEMLITITTTMLTFGMGASTQALFARVGGGIYTKAADVGADLVGKVEANIPEDDPRNPATIADNVGDNVGDVAGMGADLYESYCGSILSTAALGATAFAASSGDMQLKAVIAPMLIAAVGVFLSLFGIFLVRTKEGATMKDLLHALGLGTNTAAVLIAAVSFLILYLLGLENWLGVSFSVIAGLAAGVIIGQATEYYTSQSYMPTKAISEASHTGAATVIIKGIGTGMISTCVPVLSISVAIMLSYLCANGFDMSMSALSIQHGLYGIGIAAVGMLSTLGITLATDAYGPIADNAGGNAEMSELGAEVRQRTDALDALGNTTAATGKGFAIGSAALTALALLASYIEEIKIAMARVGTQMTNVAGETIDATKATIPDFMNFFQVNLMNPKVLVGAFIGAMAAFLFCGLTMGAVGRAAGKMVEEVRRQFREIKGILEGTGTPDYGRCVEISTQSAQHEMIIPSLLAIIIPVVVGLLLGVAGVLGLLVGGLAAGFTLAVFMSNAGGAWDNAKKYVEEGNFGGKGSEAHKATIVGDTVGDPFKDTSGPSLNILIKLMSMVSIVMAGLTVACL
>CP022041.2|ASE18296.1|527410_528142_-|NADPH-dependent-oxidoreductase
MKTINTRKTIRKYTNKDVSEDLLRTLLEKAERTPTMGNLQLYSVIITRNEEKKAQLAPAHFNQPMVMGAPVVLTFCADFRRTTLWAENRKATPGYDNFLSFLNAATDALLYCQTFCNLAEEEGLGTCFLGTTIYNPKTIIEVLQLPRLVMPVATITLGWPAEDPALTDRLPIDSIIHHETYEDYTPDRIDAFYTPKEQLEENKHFVEINNKETLAQVFTDLRYTKEANEAISKALLETLKGQW

Crispr_ID: CP022041_9

• CRISPR_ID: CP022041_9
• CRISPR_location: 526884-526967
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_9

Consensus_repeat	Method
ACCCCTCCCCCAAAGGGAGGGGAGT	CRISPRCasFinder

spacers of CP022041_9

>9.1|526909|34|CP022041|CRISPRCasFinder
GAAATGTAACGAAAGCAACTGGCCCCACCCCCCA

CRISPR arrays and Neighbor proteins around CP022041_9

CRISPR arrays

The CRISPR arrays of CP022041_9

>merge|CP022041|9|526884-526967|CRISPRCasFinder
ACCCCTCCCCCAAAGGGAGGGGAGTGAAATGTAACGAAAGCAACTGGCCCCACCCCCCAACCCCTCCCCCATAGGGAGGGGAGT

>CP022041|9|8|526884-526967|CRISPRCasFinder
ACCCCTCCCCCAAAGGGAGGGGAGT	GAAATGTAACGAAAGCAACTGGCCCCACCCCCCA
ACCCCTCCCCCATAGGGAGGGGAGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18908.1|536637_538239_+|Na+/H+-antiporter	unknown	unknown	gnl|CDD|223104
CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein	unknown	unknown	gnl|CDD|224137
CP022041.2|ASE18302.1|539957_540746_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|380361
CP022041.2|ASE18300.1|534114_535521_+|chromosomal-replication-initiator-protein-DnaA	unknown	unknown	gnl|CDD|273037
CP022041.2|ASE18909.1|540760_540955_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18297.1|528239_530840_+|adenosylcobalamin-dependent-ribonucleoside-diphosphate-reductase	unknown	unknown	gnl|CDD|274168
CP022041.2|ASE18294.1|522803_523061_-|acyl-phosphate-glycerol-3-phosphate-acyltransferase	unknown	unknown	unknown
CP022041.2|ASE18906.1|523116_523323_-|peptidase	unknown	unknown	unknown
CP022041.2|ASE18296.1|527410_528142_-|NADPH-dependent-oxidoreductase	unknown	unknown	gnl|CDD|380322
CP022041.2|ASE18299.1|532757_533738_+|MCE-family-protein	unknown	unknown	gnl|CDD|224380
CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein	unknown	unknown	gnl|CDD|274507
CP022041.2|ASE18295.1|524521_526729_-|sodium-translocating-pyrophosphatase	unknown	unknown	gnl|CDD|376979
CP022041.2|ASE18907.1|530978_531362_+|dihydroneopterin-aldolase	unknown	unknown	gnl|CDD|376737
CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	unknown	unknown	gnl|CDD|369630
CP022041.2|ASE18291.1|520656_521109_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase	unknown	unknown	gnl|CDD|379112
CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR	unknown	unknown	gnl|CDD|234616
CP022041.2|ASE18298.1|531414_532746_+|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl|CDD|119407
CP022041.2|ASE18293.1|521908_522388_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18301.1|538767_539934_-|NADH-dependent-alcohol-dehydrogenase	unknown	unknown	gnl|CDD|341466

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18908.1|536637_538239_+|Na+/H+-antiporter	gnl|CDD|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	6.20846e-77
CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein	gnl|CDD|224137	COG1216, COG1216, Predicted glycosyltransferases [General function prediction only].	6.12833e-47
CP022041.2|ASE18302.1|539957_540746_-|cupin-domain-containing-protein	gnl|CDD|380361	cd02233, cupin_HNL-like, Granulicella tundricola hydroxynitrile lyase (GtHNL) and related proteins, cupin domain. This family includes archaeal, eukaryotic, and bacterial proteins homologous to hydroxynitrile lyase from Granulicella tundricola (GtHNL), a novel class of HNLs that does not show any sequence or structural similarity to any other HNL and does not contain conserved motifs typical of HNLs. HNLs comprise a diverse group of enzymes that vary in terms of their substrate specificity, enantioselectivity and the need for a co-factor. In plants, they catalyze the reversible cleavage of cyanohydrins, yielding HCN and aldehydes or ketones. Also included in this family is TM1010 from Thermotoga maritima, a protein of unknown function. Some but not all members of this family have N- or C-terminal carboxymuconolactone decarboxylase domains in addition to the cupin domain. Members of this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	6.68078e-38
CP022041.2|ASE18300.1|534114_535521_+|chromosomal-replication-initiator-protein-DnaA	gnl|CDD|273037	TIGR00362, DnaA, chromosomal replication initiator protein DnaA. DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair].	5.95768e-162
CP022041.2|ASE18296.1|527410_528142_-|NADPH-dependent-oxidoreductase	gnl|CDD|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	3.3976e-74
CP022041.2|ASE18297.1|528239_530840_+|adenosylcobalamin-dependent-ribonucleoside-diphosphate-reductase	gnl|CDD|274168	TIGR02504, ribonucleotide_reductase, ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent. This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	0
CP022041.2|ASE18299.1|532757_533738_+|MCE-family-protein	gnl|CDD|224380	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism].	4.03207e-13
CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein	gnl|CDD|274507	TIGR03296, hypothetical_protein, M6 family metalloprotease domain. This model describes a metalloproteinase domain, with a characteristic HExxH motif. Examples of this domain are found in proteins in the family of immune inhibitor A, which cleaves antibacterial peptides, and in other, only distantly related proteases. This model is built to be broader and more inclusive than pfam05547.	2.71626e-55
CP022041.2|ASE18295.1|524521_526729_-|sodium-translocating-pyrophosphatase	gnl|CDD|376979	pfam03030, H_PPase, Inorganic H+ pyrophosphatase. The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists.	0
CP022041.2|ASE18907.1|530978_531362_+|dihydroneopterin-aldolase	gnl|CDD|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	1.97542e-37
CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein	gnl|CDD|369630	pfam07980, SusD_RagB, SusD family. This domain is found in bacterial cell surface proteins such SusD and SusD-like proteins, as as well RagB, outer membrane surface receptor antigen. Bacteroidetes, one of the two dominant bacterial phyla in the human gut, are Gram-negative saccharolytic microorganisms that utilize a diverse array of glycans. Hence, they express starch-utilization system (Sus) for glycan uptake. SusD has 551 amino acids, and is almost entirely alpha-helical, with 22 alpha-helices, eight of which form 4 tetra-trico peptide repeats (TPRs: helix-turn-helix motifs involved in protein-protein interactions). The four TPRs pack together to create a right-handed super-helix. This is predicted to mediate the formation of SusD and SusC porin complex at the cell surface. The interaction between SusC and TPR1/TPR2 region of SusD is predicted to be of functional importance since it allows SusD to be in position for oligosaccharide capture from other Sus lipoproteins and delivery of these glycans to the SusC porin. The non-TPR containing portion of SusD is where starch binding occurs. The binding site is a shallow surface cavity located on top of TPR1. SusD homologs such as SusD-like proteins have a critical role in carbohydrate acquisition. Both SusD and its homologs, contain about 15-20 residues at the N-terminus that might be a flexible linker region, anchoring the protein to the membrane and the glycan-binding domain. Other homologs to SusD have been examined in Porphyromonas gingivalis such as RagB, an immunodominant outer-membrane surface receptor antigen. Structural characterization of RagB shows substantial similarity with Bacteroides thetaiotaomicron SusD (i.e alpha-helices and TPR regions). Based on this structural similarity, functional studies suggest that, RagB binding of glycans occurs at pockets on the molecular surface that are distinct from those of SusD.	3.91272e-58
CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase	gnl|CDD|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.39499e-24
CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR	gnl|CDD|234616	PRK00076, recR, recombination protein RecR; Reviewed.	6.95636e-114
CP022041.2|ASE18298.1|531414_532746_+|N-acetylmuramoyl-L-alanine-amidase	gnl|CDD|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	8.66866e-60
CP022041.2|ASE18301.1|538767_539934_-|NADH-dependent-alcohol-dehydrogenase	gnl|CDD|341466	cd08187, BDH, Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. The butanol dehydrogenase (BDH) is involved in the final step of the butanol formation pathway in anaerobic micro-organism. Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process. Activity in the reverse direction is 50-fold lower than that in the forward direction. The NADH-BDH has higher activity with longer chained aldehydes and is inhibited by metabolites containing an adenine moiety. This protein family belongs to the so-called iron-containing alcohol dehydrogenase superfamily. Since members of this superfamily use different divalent ions, preferentially iron or zinc, it has been suggested to be renamed to family III metal-dependent polyol dehydrogenases. This family also includes E. coli YqhD enzyme, an NADP-dependent dehydrogenase whose activity measurements with several alcohols demonstrate preference for alcohols longer than C3. The active site of YqhD contains a Zn metal, and a modified NADPH cofactor bearing OH groups on the saturated C5 and C6 atoms, possibly due to oxygen stress on the enzyme, which would functionally work under anaerobic conditions.	0

Protein sequences

>CP022041.2|ASE18295.1|524521_526729_-|sodium-translocating-pyrophosphatase
MEHIPQVFWLIPIASVCALGMAWYFFKSMMKAEEGTPRMVEIAEYVRRGAMAYLKQQYKVVLIVFVVLAIVFAIMAYGFNAQNEWVPFAFLTGGFFSGLAGFFGMKTATYASARTANAARNGLNDGLKIAFRSGAVMGLVVVGLGLLDIAIWFIVLTWFYSDKMTTSEMLITITTTMLTFGMGASTQALFARVGGGIYTKAADVGADLVGKVEANIPEDDPRNPATIADNVGDNVGDVAGMGADLYESYCGSILSTAALGATAFAASSGDMQLKAVIAPMLIAAVGVFLSLFGIFLVRTKEGATMKDLLHALGLGTNTAAVLIAAVSFLILYLLGLENWLGVSFSVIAGLAAGVIIGQATEYYTSQSYMPTKAISEASHTGAATVIIKGIGTGMISTCVPVLSISVAIMLSYLCANGFDMSMSALSIQHGLYGIGIAAVGMLSTLGITLATDAYGPIADNAGGNAEMSELGAEVRQRTDALDALGNTTAATGKGFAIGSAALTALALLASYIEEIKIAMARVGTQMTNVAGETIDATKATIPDFMNFFQVNLMNPKVLVGAFIGAMAAFLFCGLTMGAVGRAAGKMVEEVRRQFREIKGILEGTGTPDYGRCVEISTQSAQHEMIIPSLLAIIIPVVVGLLLGVAGVLGLLVGGLAAGFTLAVFMSNAGGAWDNAKKYVEEGNFGGKGSEAHKATIVGDTVGDPFKDTSGPSLNILIKLMSMVSIVMAGLTVACL
>CP022041.2|ASE18906.1|523116_523323_-|peptidase
MSPIVDWNLLDVLNKNIRDNYERIRPILLKWQENGYIKLIEDNEIAFSFIPEKLPSKEKLIEESLNFK
>CP022041.2|ASE18294.1|522803_523061_-|acyl-phosphate-glycerol-3-phosphate-acyltransferase
MKRIKIIRVLATFICHDPFAYSPIWTWDGFPPIIYTERERILPVLKEWEHKGYLTLIYDEKIAFILNVEKLPSKEKLIEESRNIK
>CP022041.2|ASE18293.1|521908_522388_-|hypothetical-protein
MLLVAAMVVSISASAQFQEGKGYLGASLTGLDLHYNGHDGMNIGVQAKAGYFPWDNLMVLATFDAVHNGSEAVADHISVGVGGRYYITQNGLYLGAGVKLLHANHNYNDLMPGVEVGYAFFINRSVTIEPALYYDQSFKTHNYSTVGLKVGLGIYLFDD
>CP022041.2|ASE18292.1|521116_521725_-|recombination-protein-RecR
MQQYPSQLLERAVEAFSQLPGVGRKTALRLVLHLLRQSTEDVDSFADAVIRVKHDVKYCKVCHNISDNEVCSICSDPRRDASVVCVVENIQDVMAIENTQQFHGLYHVLGGIISPMDGIGPHDLEIESLVERVEEGTVKEIILALASTMEGDTTNFYISRKLKDTGVKLSVIARGISVGDELEYTDEVTLGRSILNRTPFES
>CP022041.2|ASE18291.1|520656_521109_-|hypothetical-protein
MDKTRKILLIEFFGSCLITLLIIAVYELELILPGAWADVESSNMVTVQFLMQLLTLATIPLALFLFKIGYVHSDLHTDESHVSRKLLFWGSVRIMMLCVPMILNTFFYYAFGDSVSFFYLAVILALSLFFVFPNKKRCEHECSMDNSEQA
>CP022041.2|ASE18290.1|519453_520656_-|glycosyltransferase-family-2-protein
MKLSVVIVNYNVKYYLQQCLESLQRALKGVEAEVFVVDNHSHDGSVAYLRSRFPDVHFIASAHNLGFAGGNNIAIRQSKGEYVLLLNPDTVVGEEVIHASIDFMDSHLTAGGHGVQMLTHCGERALESRRGLPSPMVSFYKMVGLCKHFPQSGRFAHYYMGSLSWDVPGKIEVISGAYCFLRRTALDKVGLLDEDFFMYGEDVDLSYRLLKGGFENWYLPVRILHYKGESTQKSSFRYVHVFYDAMLIFFRKHYGGMNVLWRLPIKTAIYVKAFGSLIGTTIRATRKKLGFRTSKAKSFPHYIFVAGEDVMGKCQRLATDNALVAEYRVADKDSLQHMHADLLKEFGGKSRAYCIVYDTDLFSYQDILNVFAEQPKQNIHIGFYHRKENRVVTMMEVIGD
>CP022041.2|ASE18289.1|518931_519450_-|N-acetyltransferase
MEKKQYVEVRLRAMEPEDLDMLYHIENDRSLWNISATNVPYSRYALHNYIADAKNDIYIDGQLRMMIENREQEIVGVIDLVNFDPKHQRAEMGIIIMKPFRQKGYAKAAISALIDYTRNGLHLKQIYAVVDVDNEVSIRCLSSIGFTNGSILKEWLYCDGQYKDARVMQLFI
>CP022041.2|ASE18287.1|515849_517628_+|M6-family-metalloprotease-domain-containing-protein
MKKIITLLVSVLLATSSFAIPAMRMWRSFKQADGTILKVMTVGDEHFNYALTEDNIPVLPHNGSYYYARIEDNQLVPSSVLAHDKALRKGKEELVAAAIQQVRQLQKQHEMHVNSKPFGEGLGMTWEGKKKGLVILVEFEDVAFKDPKNVLTLKPREKDVKTLYENMLNKVGYTNDNGAIGSVHDYFLDQSNGKFDLTFDVVGPVKLKHPHQFYGERTANMNDANAPQMIIDACNAIQGQVDFSKYDWDDDGEVEQVYVIYAGEGEATGGESSTIWPHKYSLTDAGLDALTFNGQTINTYACSNEIIRAKVNEKSRIYYSGIGTICHEFSHCLGLPDFYDTRGGSNIGSGRYDLMCGGSYNGGPESLINVYGGTGIGTVPAGYDAYEKAYMGWLKPITLGDEAVEVKNMKGLAEGGDAYFLYNPDTKNEYYIFENRTPHRWDAELPGHGLMVFHVDFDAYSWRMNNLNAASAQRHPRFTIVSADGRLDHDTQNSDPFPTDLNNSLTKSTDPRLSFYTNYNVSSQAGVKQIVRNNDNTISFHFTPLKAATGINNLSADHEQLAETYTLSGVKVADNQNLHNQIVIVKGKKVRK
>CP022041.2|ASE18286.1|513287_514901_+|RagB/SusD-family-nutrient-uptake-outer-membrane-protein
MKTVRTYILAGVAAFALTSCNDYLTTVPKDAMSPSTTWKTGDDAEKFLVGCYDGWEDGGALLYWDAGSDFAYNNFPWEGFTNIGNGSLSPSSPGWSFYDYTIIGRCNTFLENVDKCVFSSDAVKKDLVAQVKAIRAYNYFRMGFLYGGVPIVKPFTSAQEARVPRNTEQEVKDLVFKDLDEAIADINTSPAARGRIAKGAALAMKMRAALYWGDYQKAKDAAQAIIDLGKYELDPDYTNLFKLAGVDSKEIILAVQYKSGTRPLGTIGQLYNNGDGGWSSVVPTQKCVDNYEMSNGMTITEAGSGYDATHPFHGRDPRMAMTILYPGCDWEGTIFNTLDENVNGKKNPNYPTNAANSSKTALTWRKYLDPKTQYADVWDTEACPIVFRYAEVLLTWAEAENELNGPSANVYAMIDKVRTRVGMPAVDQSKYNTKDKLRELIRRERGSEFAGEGLRRADILRWTSNGKMVAETVLNGPLNRITGTINTSATDPTMRAVVSGSSKVEDRTFQTFNRYLPIPQWNISDNPKLEQNPGYAK
>CP022041.2|ASE18296.1|527410_528142_-|NADPH-dependent-oxidoreductase
MKTINTRKTIRKYTNKDVSEDLLRTLLEKAERTPTMGNLQLYSVIITRNEEKKAQLAPAHFNQPMVMGAPVVLTFCADFRRTTLWAENRKATPGYDNFLSFLNAATDALLYCQTFCNLAEEEGLGTCFLGTTIYNPKTIIEVLQLPRLVMPVATITLGWPAEDPALTDRLPIDSIIHHETYEDYTPDRIDAFYTPKEQLEENKHFVEINNKETLAQVFTDLRYTKEANEAISKALLETLKGQW
>CP022041.2|ASE18297.1|528239_530840_+|adenosylcobalamin-dependent-ribonucleoside-diphosphate-reductase
METKQTYSFDEAFQASLAYFGGDELAARVWVNKYAMKDSFGNIYEKSPEQMHWRIANEIARIENKYKNPLTAQEVFDLLHHFKYIIPAGSPMTGIGNNYQVASLSNCFVIGLDGNADSYGAIMRIDEEQVQLMKRRGGVGHDLTHIRPKGSPVNNSALTSTGLVPFMERYSNSTREVAQDGRRGALMLSVSIKHPDSEAFIDAKMEEGKVTGANVSVKITDEFMQAVVEDKTYVQQFPTNSSEPSVTKEISAKELWEKIVHNAWKSAEPGVLFWDTIIRESIPDCYADLGFQTVSTNPCGEIPLCPYDSCRLLSLNLYSYVIDPFTDHARFDMELFKRHAQLAQRLMDDIIDLEMEKIDLIMSKIKTDPQVDEVKSAEYHLWEKIKKKSCQGRRTGVGITAEGDMIAAMGLRYGTQEATDFSVDIHRTLALNAYRSSVTMAQERGAFEIYDAKREEKNPFILRLKEADGQLYEDMKKYGRRNIACLTIAPTGTTSLMTQTTSGIEPVFMPVYKRRRKVNPNDTDVHVDFVDEVGDSFEEYIVYHRKFLTWMEVNGIDTQKKYSQEEIDELVKRSPYYKATANDVDWLMKVRMQGEIQKWVDHSISVTVNLPNQVDEELVNKLYVEAWRSGCKGCTIYRDGSRSGVMISVSKKDKTKDEKPVDEEKVKDLNSAEEHHEHICNHPNVIEVRPKELECDVVRFQNNKEKWVAFVGLLEGYPYEIFTGLQDDEEGIALPKSVTKGKIIKQTAEDGSHRYDFQFENKRGYKTTVEGLSEKFNPEYWNYAKLISGVLRYRMPIDHVIKLVGSLQLKNESINTWKNGVERALKKYVVDGTSASGLKCPVCGQETLVYQEGCLICTNCGASRCG
>CP022041.2|ASE18907.1|530978_531362_+|dihydroneopterin-aldolase
MKLMTSYILLQGLHFHACIGVGEQERVVGNEYVLDLRLGYPFVTAMKSDDVADTLNYAEVFNVIREVMKQPVRLLESVAGSIVEALFAVFPMISSIDLKLVKLNPPMGADSDGAGVELHLINDKTEV
>CP022041.2|ASE18298.1|531414_532746_+|N-acetylmuramoyl-L-alanine-amidase
MFKKISLLLVFLVLSVSLSWAADGRFTLVIDPGHGGHDAGAIGAISKEKDINLNIALAFGRYVERNLPDVNVIYTRKTDVFIPLHQRADIANKAKADLFISVHTNSVASGRYVKGFQVYTLGMHRAKANLDVAMRENGVISMEKGYQQTYQGFDPNSSESYIMFEFMQNANMERSVELARMIQNSVCSSAGRIDKGVHQAGFLVLRESYMPSCLIELGFITAADEEEYLNSPAGIDAMAKGIYNAFVQYKNAYDTRIVVPYRPVENKRIVIDRVVPTAPTTKPHPVTPIERPRSVAPVQRSRSTVPVEQPRSSTPAPPARPMNKVQEAKKRISDAIRELLPCNDSEAETAKSVPVFKVQVLASNRQLRSGSELFRGHTDIDCVQEGNFYKYCIGSSTNYNDISRLRGKLLKDFSQACIIAYKNGARMDVNQAIAEFLKNKKNK
>CP022041.2|ASE18299.1|532757_533738_+|MCE-family-protein
MKKFFTPQVRIAIVAILAIVVLFFGIQFLRGISLFSNDAHYKIKFNDITGLSTSTPVYARGFKVGIVRNIDYDYDKLGESITVDIDVEKTLRIPEGTTAEIVSDIMGNVKVVLQFGKSTKLLEPNGWIDGVINDGTLGDLKSMVPSIQKMLPKLDSILGSVNTLLGDPALQSSVHNIDKITANLTTSTRELNTLLAQVNGSLPVVAAKAGRVMDNANGMMVNANRGVTEARGAIRGANTMMSNLNNKVNGLDVEATVAKVNATLDNMNSLTAKLNSNEGTMGLMLNDASLYNNLNSTMRSADSLLTNLKAHPKRYVHFSIFGRKDK
>CP022041.2|ASE18300.1|534114_535521_+|chromosomal-replication-initiator-protein-DnaA
MNVSPKNLWDSCLQLIKENVTEQQFDTWFRPIVLQSYKPASKTLLVQVPSQFVYEYLEGHYVDLLRKVLTRVFGQGVQLTYRVMVDQENHLSQDLEQDTVEDISSQRPTARANQSPTVLDTVPQDLDSQLDPHKSFSNYVEGDSNKLPRSIGLSIAEHPNTTQFNPMFIYGPSGCGKTHLVNAIGLKAKQLYPQKRVLYVSARLFQVQYTDSVRQNTTNDFINFYQTIDILIVDDIQEWVTATKTQDTFFHIFNHLFRNGKRIILASDRPPVDLKGMNDRLLTRFSCGLIAELEKPNVQLCVDILHSKIKRDGLNIPEDVVRFIAETANGSVRDLQGVINSLLAYSVVYNSNIDMRLAERVIKRAVKIDDEPLTIDDILDKVCTHYNVTMSAVNSRSRKKDIVMARQVSMYMAQKYTKMPASRIGKLVGNRDHSTVIHSCSKIEDRLKVDKGFHAEIASIENSFKLKA
>CP022041.2|ASE18908.1|536637_538239_+|Na+/H+-antiporter
MEHQLVLIIALILATCLLIMVSQRVKVAYPIMLVLGGVAMSFIPGMPRFNINPDLIFLVFLPPILYEAAYYNSWKELWRWRRIISSFAFIVVFITALVVGFIANTFIPGFSVALGFLLGGIVSPPDAVSAAAIMKFVKVPRRISAILEGESLFNDASSLIIVKFALIAIGTGQFVWYQATASFIWMVIGGAGVGVLLSYAIIKLHKWLHKWLPIDENINTMFTIFSPYVMYIAAETVEASGVLAVVSGGLYFSYRRLQIIGSSSRLRSEHVWNFLIFLLNGMAFLLIGLDLPEIMTGLKEDSVSLWMATAYGLLITMALVVIRMGAAFSAVYITRFMSKFITVADSRKQSYAGPLVLGWTGMRGVVSLAAALSIPLYIPGTQIAFPERSLVLYITFMVITLTLIFQGLTLPVLLKIVKLPNYDDHMSHAEAQRIIRIGMAQASLDFLERNNMSENITHSAVLNNLGNHWNELLESEGSATLYDEVARKTYREILEEQRLWLNKLNNENERVDEELVRHYIHRIDLEEERLLKE
>CP022041.2|ASE18301.1|538767_539934_-|NADH-dependent-alcohol-dehydrogenase
MVNFDYWTPTRLVFGKDVVREKLVETMRPLGKRVLMTYGGGSIKKIGLYDLVKDLLKDFEIFELPGIEPNPKYDPSVLEGVRICKEQKIDVILAVGGGSVLDCSKAIAAGAYYDGEAWDLISYKVKAQKALPIVDIITLAATGSEYDCGGVITNTAINDKRGYMDALLYPVASFMDPTYTFTVPAKHTAAGTADAINHMMEQYFCASPNDISDGFLETLIKTLMKWVSVAMKEPDNYEARAELMYACTFGCNGILAMGTGGSGWPMHAIEHALSAYYDITHGVGLAIITPRWMKHVLSEKTMERFVKFGKNIYGITEGTDKEIAEQVIDRTYKFFESIDIPMHLREVGIDESRVGEMAHHVASIDHLENCPFAPLSEQDIAEIVTASL
>CP022041.2|ASE18302.1|539957_540746_-|cupin-domain-containing-protein
MATAVMGIQAQKNMERKEIKQTAGRATLGEFAPEFAHLNDDILFGEVWNRQEEMSLHDRSLTTILSLVAQGITDSSLKYHLNTAKANGVTRQEFSEMITHAAFYIGWPKAWAVFNMAKEVWTSDIQTKEEFQASTPYPIGEPNTGYAKYFIGLNYLAPMEADKGGVVNVTFEPRCHNNWHIHHKSVQVLICVAGRGWYQEWGKEAVEMKPGTVIAIPEGVKHWHGAARDGWMQHLTYNTHVEDSSSNEWLEPVGDDVYDTLK
>CP022041.2|ASE18909.1|540760_540955_-|hypothetical-protein
MINSSDGSDILVFNCYLCHVSFLLTCYVCSTKIGEISGISKCFENFVSQALGVLTKIYAAELRE

Crispr_ID: CP022041_10

• CRISPR_ID: CP022041_10
• CRISPR_location: 740687-740792
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_10

Consensus_repeat	Method
GGGGAGTGAACAGCGTGTTATCCCTAT	CRISPRCasFinder

spacers of CP022041_10

>10.1|740714|52|CP022041|CRISPRCasFinder
GGTAGTCCTTTCGCCTTCCTCGAACCAGCAGTGAGCGTCGGTTTAGAACGGG

CRISPR arrays and Neighbor proteins around CP022041_10

CRISPR arrays

The CRISPR arrays of CP022041_10

>merge|CP022041|10|740687-740792|CRISPRCasFinder
GGGGAGTGAACAGCGTGTTATCCCTATGGTAGTCCTTTCGCCTTCCTCGAACCAGCAGTGAGCGTCGGTTTAGAACGGGGGGGAGTGAACAGCGTGTTATCCCTAT

>CP022041|10|9|740687-740792|CRISPRCasFinder
GGGGAGTGAACAGCGTGTTATCCCTAT	GGTAGTCCTTTCGCCTTCCTCGAACCAGCAGTGAGCGTCGGTTTAGAACGGG
GGGGAGTGAACAGCGTGTTATCCCTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18436.1|724571_727748_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
CP022041.2|ASE18448.1|745425_745956_-|50S-ribosomal-protein-L19	unknown	unknown	unknown
CP022041.2|ASE18917.1|722737_724513_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl|CDD|378943
CP022041.2|ASE18918.1|731399_735416_-|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl|CDD|223715
CP022041.2|ASE18442.1|740167_740512_+|50S-ribosomal-protein-L20	unknown	unknown	gnl|CDD|179959
CP022041.2|AVV27050.1|742650_745284_-|RNA-binding-transcriptional-accessory-protein	unknown	unknown	gnl|CDD|225094
CP022041.2|ASE18450.1|749617_750628_-|iron-ABC-transporter-permease	unknown	unknown	gnl|CDD|376439
CP022041.2|ASE18435.1|721672_722671_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18444.1|741647_742082_-|transcriptional-regulator	unknown	unknown	unknown
CP022041.2|ASE18437.1|727775_728990_-|endoglucanase	unknown	unknown	gnl|CDD|365907
CP022041.2|ASE18449.2|745979_746552_-|twin-arginine-translocation-pathway-signal-protein	unknown	unknown	gnl|CDD|379310
CP022041.2|ASE18451.1|751910_753377_+|dihydroorotate-dehydrogenase	unknown	unknown	gnl|CDD|238535
CP022041.2|ASE18441.1|739934_740132_+|50S-ribosomal-protein-L35	unknown	unknown	gnl|CDD|234676
CP022041.2|ASE18920.1|750649_751780_-|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|238561
CP022041.2|ASE18919.1|746769_748911_-|M3-family-peptidase	unknown	unknown	gnl|CDD|341051
CP022041.2|ASE18440.1|739140_739821_+|translation-initiation-factor-IF-3	unknown	unknown	gnl|CDD|234582
CP022041.2|ASE18445.1|742146_742644_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18443.2|741003_741597_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18438.1|729490_730708_+|IS4-family-transposase	unknown	unknown	gnl|CDD|372999
CP022041.2|ASE18439.1|736805_738755_-|threonine--tRNA-ligase	unknown	unknown	gnl|CDD|234752

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18436.1|724571_727748_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
CP022041.2|ASE18920.1|750649_751780_-|ABC-transporter-substrate-binding-protein	gnl|CDD|238561	cd01141, TroA_d, Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind their ligands in the cleft between these domains.	3.66834e-22
CP022041.2|ASE18917.1|722737_724513_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl|CDD|378943	pfam12771, SusD-like_2, Starch-binding associating with outer membrane. SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.	1.98634e-37
CP022041.2|ASE18918.1|731399_735416_-|hybrid-sensor-histidine-kinase/response-regulator	gnl|CDD|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	6.17671e-49
CP022041.2|ASE18442.1|740167_740512_+|50S-ribosomal-protein-L20	gnl|CDD|179959	PRK05185, rplT, 50S ribosomal protein L20; Provisional.	9.70538e-60
CP022041.2|AVV27050.1|742650_745284_-|RNA-binding-transcriptional-accessory-protein	gnl|CDD|225094	COG2183, Tex, Transcriptional accessory protein [Transcription].	8.80708e-121
CP022041.2|ASE18450.1|749617_750628_-|iron-ABC-transporter-permease	gnl|CDD|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.1318e-67
CP022041.2|ASE18437.1|727775_728990_-|endoglucanase	gnl|CDD|365907	pfam00150, Cellulase, Cellulase (glycosyl hydrolase family 5).	9.76418e-46
CP022041.2|ASE18451.1|751910_753377_+|dihydroorotate-dehydrogenase	gnl|CDD|238535	cd01115, SLC13_permease, Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.	3.02559e-77
CP022041.2|ASE18441.1|739934_740132_+|50S-ribosomal-protein-L35	gnl|CDD|234676	PRK00172, rpmI, 50S ribosomal protein L35; Reviewed.	1.7954e-20
CP022041.2|ASE18919.1|746769_748911_-|M3-family-peptidase	gnl|CDD|341051	cd06456, M3A_DCP, Peptidase family M3, dipeptidyl carboxypeptidase (DCP). Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.	0
CP022041.2|ASE18449.2|745979_746552_-|twin-arginine-translocation-pathway-signal-protein	gnl|CDD|379310	pfam13645, YkuD_2, L,D-transpeptidase catalytic domain. This family is related to pfam03734.	5.73918e-37
CP022041.2|ASE18440.1|739140_739821_+|translation-initiation-factor-IF-3	gnl|CDD|234582	PRK00028, infC, translation initiation factor IF-3; Reviewed.	3.51759e-83
CP022041.2|ASE18438.1|729490_730708_+|IS4-family-transposase	gnl|CDD|372999	pfam14294, DUF4372, Domain of unknown function (DUF4372). This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with pfam01609. There is a single completely conserved residue G that may be functionally important.	4.2794e-21
CP022041.2|ASE18439.1|736805_738755_-|threonine--tRNA-ligase	gnl|CDD|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0

Protein sequences

>CP022041.2|ASE18442.1|740167_740512_+|50S-ribosomal-protein-L20
MPRSVNHVASKAKRTRILKQTKGYYGARKNVWTVAKNTYEKGLTYAYRDRRNKKRNFRALWIQRINAAARLYDMSYSQLMGALHKAGIEINRKVLADLAVNNQEAFKAIVDKVK
>CP022041.2|ASE18441.1|739934_740132_+|50S-ribosomal-protein-L35
MPKQKTNSGAKKRFTFTGTGKIKRHHAYHSHILTKKTKKQKRNLVHQTLVDGTNLKQVRDLLRLR
>CP022041.2|ASE18440.1|739140_739821_+|translation-initiation-factor-IF-3
MKNDKMKMKYRVNEQIRVREVRVVSDDGAEVMPTRKALELAQKEGVDLVEISPNAQPPVCRIIDYSKFLYQQKKHQKEMKQKQVKQEVKEIRFGPQTDEHDYKFKLKHAQEFLNAGNKVRAYVFFRGRSILFKEQGEVLLLRFANDLEELAKVEQLPKLEGKKMFLYLAPKKAGVAKKSQQKRDREEAEAGAKAGAEGVSEEPKTDGGLFANAKNGADALKKLNID
>CP022041.2|ASE18439.1|736805_738755_-|threonine--tRNA-ligase
MVKITFPDGSVREYEQGVTGFQIAESISPALARDVVSCGVNGETTELNRPINEDATIALYKFDDEEGKHTFWHTSAHLLAEALQELYPGIQFGFGPAVENGFFYDVMPAEGQTISENDFPKIEEKMRELAKKNEQVVRRDVSKADAVKEFTADGQEYKVEHIVEDLEDGTISTYSQGNFTDLCRGPHLVSTGAIKAVKITSVAGAFWRGDAKREQMTRIYGITFPKKKMLDEYLEMLEEAKKRDHRKIGKEMELFMFSDRVGKGLPIWLPKGTQLRLRLQELLRRLLRPYNYQEVITPGIGGKNLYVTSGHYAHYGKDAFQPIHTPEEDEEYMLKPMNCPHHCEIYAHKPRSYKDLPLRIAEFGTVFRYEKSGELHGLTRVRTFTQDDAHIFVRPDQVKAEFENNIDIILKVFKTFGFDNYEAQISLRDPEDKEKYIGSDEVWEESEAAIKEACAEKGLNARVELGEAAFYGPKLDFMVKDAIGRRWQLGTIQVDYNLPNRFKLEYTAEDNSKKTPVMVHRAPFGSLERFTAVLIEHTAGHFPLWLTPDQVAILPISEKYNDYARKVKAYFDAHDVRSIMDDRNEKIGRKIRDNELKRVPYMVIVGEKEAAEGLVSMRQQGGGEQATMTMEAFAERINNEVAEQLKGLD
>CP022041.2|ASE18918.1|731399_735416_-|hybrid-sensor-histidine-kinase/response-regulator
MLMLSNLNTDNGLSSARVYSIVEAEDGAMWISTKRGVDRYNGQQVRNYTLATDMQFSDASGRNIKLTKNSQQHIYAYDNKGKIYIYNKVKDTFQLQVNLMNVLGGSVVLNDLLVDDKGCFWMALDRGVYMMAPLSIAGSKDKTAYSSSNKGKYILKNTYVNHIRFFGKQLLIGSPSGVFAYSQNAAQPRLLLRGYSVLSSYHDVKAHQIWLGTFHRGILLLDDRTWKPLSSLTQFSSLSDIPLIPVRSIIPYDAATILMAVDGAGVYAYDKKTCKTNLLLNTDGRPENVLHGNGVYALCKDHLGDLWMGSYSGGVDMAIPMEHTLEFVRHENLNSQSLINNGVNDVMQSVDAQGRNSKIWYATDKGVSIYDEQTHLWHHSLYNKVALTLCQTADGKVLVGTYGDGIFQVHADGSSSRAYSVSNGKLKTDYVYSIFKDSEGGLWIGCLDGDLVHIPSSLEKNGNVDNSVNYLPINEVQSIVESPDKKIIAVGTTHGCYRIDKRSLRVSRFFYPSEFPSVDYNFFVNAMDFQDARHIWIATDGGGLYLYDWQKHQVKNYTISQSLPSNTVYALVKTPIGQVWMSTDKGLAFIDHGKVINLNFFKGLEREYKRMAVVRTQDGRMIFGSSEGAVVLASKFARGLNYKAPLHITGVEVEGKTFDEADQLEDWHAELFEMLQEGKMSFSHDEKTLIVHFESINYPYQHDIQYQYYLAGYDHQWSVPSAYQQARFANLPPGSYTLHVKAMGRSNGRILGESTLRIHIAQPWWNSWWAWIAYLCILGVIVYFGWDYYRERLHRKYYDDKINFFVNTAHNIRTPLSLVLAPLADLAKDTTLGDKSRKFLEMALCNGDKLLRMVTELLDFQKIAVVKTQVHMQKVELSVLLRQQVDKFQMSAQEKHLNLRLATCGQHTFSTDLSMMDLIFENLLSNAIKYTKVGGTITISASIDEIGKQVSIQVSDTGIGIPKIEAKHIFQSFFRASNAVNSQEMGSGLGLMLTRQLVQKLGGKLTFESEEGKGSTFLVVLPDNGYVDVSVSSKPSSLPETSDNSMSTDEKIKSEESLKDTLLFVDDNEDFRQYIRMAFADQYHVVDVESGEAALKYLSENGECDIVVSDVMMPGMQGDELCRSIKENKETSWLPVILLTAKAGRDFMIEGLDLGADDYIAKPFDSAILASKITSMLKNRCRLSQYYMERSLAIVRGEDSGQSSQKSLLPSEPSMSSASDEKNKSSDEKELGLDPMDQAFVEKATRLILDNLSDTDFTIDRLCREMAMSRTLFYGRLKTLTGQGPQDFIRLIRLEQAAQYLKQGDSVLDVSMKTGFVNVKYFSTVFKKHFGVSPSKYD
>CP022041.2|ASE18438.1|729490_730708_+|IS4-family-transposase
MGKSTHFIGQPVYNQVIKLLDKQQIKQISLETPRSEAYVKRLDGWTHLVIMLFVVLKHFDSLREVEIGMKAEVNKFHHLGIDYIVRRSTLADANKRRPQEFFASVYAYLLERYGSFLSDSRPKGEQKTWEKLLYMMDSTTITLFDNILKGVGRHPKSGKKKDGMKVHTVMKYHVGVPMVVQLTSAATHDHYLLKEVHLPKDATLTMDRAYVDYAQFQRLTEEGVCYVTKMKKNLTYTELSSVTYVSPDGLVTHTDKKIVFEKGEIRHQARRVELWSDNSHKSVVLLTNNLELDVKDLEEIYKRRWAIESLYKQLKQNFPLHFFYGDSVNAIQIQTWVVLIANLLCTVISRMIKRHVSFSQLVTMLRLTLMYYTDFISFMENPQNDELIIIAEKANSPPKELDLFD
>CP022041.2|ASE18437.1|727775_728990_-|endoglucanase
MKRNLLKICLLFVSMFTVFSCSASPSVVDTPDTSESIPTAKQWNKDVVGWNLGNEFECSAPGQDGESMQIGNPDGSIHAETAWGNPVVTKKMIQAVKKAGFNAIRIPIRWQCHITNAQAMSIDKAWIARIKEVVGWCLDNDLKVIINAHHEKWLEGRPTYQYKDENCQKLALLWMNIASEFANYDSRLAFAGTNEVHVRDNWSKPTAENLEVQNAYNQIFVDMVRATGGNNAKRHLILQTYVCNPWFGIENGGFVIPKDAEGNGNNYMSVEFHYYQPWSYAGDCAYDYWGDAYKDVGKIPAENEKTMTDFFDKAMNTWSNKGLGIVIGEWGVTDHYKSNSVKVHENMTYYCKFLTTEARKRGFSTFVWDNNHFGNGSEKYGIFDRFKSMKVNAPWILEGIFGKE
>CP022041.2|ASE18436.1|724571_727748_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MRKKTMFLGMLGAGLMWMPTSAILAAQMNNAAMSVQQNQGIKGTVVDATGETLIGASVKVTGTTNGVVTDLDGNFTLNCKPGATLEVSYVGYKTMTVKAVNGMKIKMQVDSKALNEVVVTALGIKRDRKALGYGLEEVKGEELSKAKETNVINSLSGKVAGLVVQNTAGGASGSTRVLLRGNTEMAGNNQPLYVVDGVPLDNTNFGSAGESGGYDLGDGISAINPDDIETMTVLKGPAASALYGSRASHGVILITTKKAEKDKISVEYNGSYTVDTQLAKWDDIQEIYGAGYNGELPASSTSGTNTSWGPKADDFMFKYFDGEERPFLMHPNNASDFFRTGFTTQNSAILSVNSGKTGMRFSVTDMRNKDILPNTNMSRDNFNLRVNTSAGPVDFDFTANYTREKVKNRPALGDSQSNVGKNLMTLAGTYDQAWLKHYEDADGNYSNWNGNDQYNKNPYWDLYKNSNTSDKDVFRFTGKAIWNIDNHLKLQGTIGTDINSMNFEDFIAKTTPGTPAGKLTDQIFNNRTFNAEILALYNNSWGDFDVNATAGGNIFKVNNKTTTNVGLNQQMNGIQNIMNYQEQNTRESMYKKQISSLYASASLGYKHTYYLEGTLRGDRSSTLPTNNNTYVYPSVSGSLVFSEFIKNKKFINYGKIRASWAKVGSDTDPYLLALNYTTGKYSYSGYTIGMIANSTQPNKDLKPTMTDSYEVGLEMKFFNGRLGLDATYYNQNSKDQILSLASTTTSGYAYRLINAGEIQNQGIEIALNARALQIKDFAWDLGVNFSKNTNKVKSLTNGMDYFELAKAYWCGVSVGAKVGENYGAIRGHDFLYNDKGQVVVDAATGLPKVDQKIKTIGNSTWDWTGGFYSTFSYKNFRLSAAFDVKVGADIYSMSMRSAYQTGKAKGTLAGREEWYTSEEARKASGMDLAAWRETGNCKGFVVEGVIDNGDGTYRKNDIAVNPEDYWKHVANGVQSAFVYDNSYVKCREITFGYTFPESILGKYVKGLTVSFVARNPFIIWKNIPNIDPDSSYNTSGLGLEYGSLPSRKSYGLNVNVKF
>CP022041.2|ASE18917.1|722737_724513_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MNNIIKKYIGKSSLMMAFALMTTGTAMTSCSDETLSNINTDKTKVSELDPNAQLTTALLQTYGDFSLMDTYRNYISGFPQYFAGGWNVTNYAGSNFREDDIARRVWDRYYEVSIKNLVDAIHNSADKANLNAALRIHRVYLTAVLADTYGDVPCLEAGLGYISGISTPKYDTVEELYSWFFEELDACEKQLGTGTDRISGDVTSMGGDVAKWKKYANALRMRYAMRISDVNPQKAKEEFEKAVAAGAIASAADDAYIRYADTPYTYYDGANDYDFRTNALGEILYGQDATSPTMVCSTLFYQLQNTNDPRLYRICRHYYNIKRSQVKPDKEQNIDLTDDFLAYFRSKNLGEEPCNPGATWYTDWMSPATVDDLPTLKKYAEIDKNTYANSDYIARAGRPCLNIDFEMPSCPGDLMSYAEVEFLKAEAATKGWNVGGGDAESHYEAGVRASMELLNNYYLTSNKISKEEIDAFIANNPLGDNPKETINTQAWILHMMNPSEGWANMRRSDYPAILNRDLLTKNGFTYTDSNWSMPVRLQYPELEGQYNSANYKAAIDRMGGTDDWHKRLWWDKADVNLQPNFNPPFGKGYSK
>CP022041.2|ASE18435.1|721672_722671_-|hypothetical-protein
MNKTMKQYKGKVLKAMMMLFAMSFALAGTSTLSSCSSDDDPYFTVSENDDPRILNTDLADSKIDRKTNYKLEIKVTPVHYTTVTWLLDGTQIAEGTTIDQTLPLGNHELKIVATTTKGKTTSRTLNVTVTPAADDPALGTNAIELRVAPGETTTIHECKNLGLVQKVLIADKEVAFEVLDEGTTLKVTAPSDLANGDYDITLVDSNGVQFAGGTIKVTTEARQSVENTIWEGEFAVTWGTPFNALKDTFLSKVKAGTILRVYVNGNGQGTAATAWWNNILTGKGDPERGDIMVDGPAKWEFKLTDLSIQLLTEQDGFLLVGDGYTVKKVTIE
>CP022041.2|ASE18443.2|741003_741597_+|hypothetical-protein
MTKQDSLLSDNFGQKVDGQLKGSYRADTVSLIDKYFRRGMSRKGILMIPKGKRPAPETYLKRRYIRRHLKNFKAGASCIVSKELLERYHGDSIGKADNSQFIMMKSEMDSVLMRSHGDLSRIEHELGIPAGAWKHRVLVRIDIPKPKKLKLRMPSGNEIGANVLWLPGGLLPTGYKEAVIDRIPKGKYKASLIEITQ
>CP022041.2|ASE18444.1|741647_742082_-|transcriptional-regulator
MHDIIGGFIGLTLVHIGAALRFVYHRFIIRDNYSYHSLITESPVFDCFKESYKEQFKRWKQRQIQRNQAYDIDLNEEQQQTLEMFLKEGRSKKEIIQGMIETGELKLIDVDIYPRNPEYFSNRVLDGIIGLCFLIILILIIHYI
>CP022041.2|ASE18445.1|742146_742644_-|hypothetical-protein
MNQTKKILAYLGCIAFTALGVWLLTIENPTTTYPLWTIRVTGILSIIFFGGGGLFMAYKKVKLLINHKKEIEFTDRGISICGAEEILWNEIADFSLIRFKGNRLITIQMKNPEKVIANEPSWIKRKTMEYNLKTINALYSFPAYMMDGRAEEALTLCKLNLAKHK
>CP022041.2|AVV27050.1|742650_745284_-|RNA-binding-transcriptional-accessory-protein
MTVGSGEPEGASGASFISHSLSLPLQSVSAVLTLLNEGCTIPFISRYRKERTGGLDEVQITDISELYDRLKELGKRKETILRTIREQEKLTPELEAKILACMDSTELEDIYLPYKPKRRTRAQIAREQGLEPLALAIMREAQKPTAPPDLPEGGGDKLASILQKYQGRAKESLSSRVRIGTPPLSGRSGGALALDIIAEIVSENQQARNTVRTAYQRGAVITSKVIKKMKDTDEAQKFADYFDFSEPLRRCNSHRLLAMRRGEDQGILRVSITIDGEECIARLTRQFVRGHGVCQTLVSQAVEDSFKRLINPSIENEFAALSKGRADEEAIKVFTENLRQLLLSPPLGQKRVLALDPGFANGCKIACLDEQGNLLHHEIIYPHPPRNQVRQATEALQRMINTYNIEAIAIGNGTASRESKEFVENITTETTTGPSPSPLPHREGSDYRHLPKSKQQFTDNTSPINSKPQSAGHTTPLPLGEGSGEGPVRPVGPVGSASSLFIFLVSEDGASIYSASPVAREEFPDEDVTTRGAISIGRRLMDPLAELVKIDPKSIGVGQYQHDVDQSKLKHSLDQTVMSCVNQVGVNLNTASLHLLTYVSGLGPALARNIIDYRREHGPFTSRAQLKKVKRLGDTAYQQCAGFLRIPDAKNPLDNSAVHPESYHIVEQMAKDLKCTIKDLIGNKKLLAEIDVKRYLTPQPPLRRERGSEASPNPSERRGGAPPNLPEKGGVPMRTREDKGALNLPQHLSNVSTSLPPLLSEGSGEATLRDILTELEKPGRDPRGEVEVFEFDKNVHTLSDLIIGMELPGIVTNITNFGAFVDIGVHQDGLVHISQLSDRFVTDPTQVIRLHQHVRVRVVEVDMRRKRIALSMKNIKQ
>CP022041.2|ASE18448.1|745425_745956_-|50S-ribosomal-protein-L19
MELNLKRTLTCIILTVLTTLSTHAQTLCVIDGTPLPDSLLHVTIDEMRSDSAKEIVAKRLGLIPPQAIESIQTFAVEEQIRQGKNIIFCKPPKDIIIMRTNSLAELQWVINGKLRKPRKKLTIIDYKLSPQRITEALPKGIKPTDIGSVNILTYINDPRQEKHPTIVIKTKSLTTK
>CP022041.2|ASE18449.2|745979_746552_-|twin-arginine-translocation-pathway-signal-protein
MLLSLLTLNFGVKGYWKIKSYSFQSYFKDVWEICHEKGYNEDYCILVDFSRPSGEDRMAIIDLKTLSVLDTGPCAHGKGKGNSAWKPVFSNKEGSRCSSLGAFKIAEKGYSATVGLRFALDGLDASNSNARRRNILIHSSRYVGIMHHLTSYLPLSDASWGCFTTSPAMLKKIEALCDKSKKPILLYAYK
>CP022041.2|ASE18919.1|746769_748911_-|M3-family-peptidase
MKQNLKNVVLAAGLACTALTGQAQKARPKTTQTVSNSLMKQSTLPFNAPDFSRIKGEDYLPAIKAAIAEQRAEIKKITDNKQKPTFANTILAYERSGKDLERISNIFYALVSADKTPEIEKAQGSIVPLMTEFENEIKFNQKFFQRIKYVYDHEYKTLKGEDKKLLEVVYKDFTHAGALLPKEKMARMQEINKELAKLQQEFGDMLPKAANEATVWVSDVKELAGLSETDIAQCKKDAESRGGKAPYCIVITNTTQQPILASLENRGLRERVYNASIHRTDGTGAYNTFPVIVKIARLRAEKAQLMGYKNYASYSLSKTMAKNTDNVYAFLHQMIEAYKPKSEAQTKAIEEYAQKTEGADFRLQPYDRFYYSAKMKKDQYSFSDDDVKPYFNLDSVLVNGIFYAAHRVYGLSFRERKDIPTYHKDMKVFDVIDANGKQLALFYCDYFRRPTKRGGAWMSAFLKQSGDRHQKPLIYNVCNYAKAPEGQPTLLTWDETQTMFHEFGHALHGMLSNCKYNTLSGTAVSRDFVEMPSQFNESFASIPEVFNNYARHYKTNEPMPDALREKMLGSLNFLSAYALGENLSATSVDLAWHCLSPSEVPTVEEAPAFEKKVLADMGLLNNQIPPRYSTSYFNHIWGGGYAAGYYSYLWSEVLAANIADYFEAHGALTRKVGDDFRQKILSRGNTRDLMQIFSDFTGLKAPDTKGLLKARGM
>CP022041.2|ASE18450.1|749617_750628_-|iron-ABC-transporter-permease
MKRNILLFICLATSILLLFGLNLTTGSVQIPFADILDILCGRFIGKESWEYIILENRLPQTLTAILCGASLSVCGLMLQTAFRNPLAGPDVFGISSGAGLGVALVMLLLGGTVSTSIFTVSGFLAILTAAFVGAIAVTVLILFLSTLVRNSVLLLIVGIMVGYVSSSAVSLLNFFASEEGVKSYMVWGMGNFGAVSMNHIPPFSILCLIGIIASFLLVKPLNILLLGPQYAESLGISTRQIRNILLVVVGLLTAITTAFCGPISFIGLAIPHIARLLFRTENHQILLPGTVLSGAVIALLCNFICYLPGESGIIPLNAVTPLIGAPVIIYVIIQRR
>CP022041.2|ASE18920.1|750649_751780_-|ABC-transporter-substrate-binding-protein
MRQLLVFTLSVLLFLSCGNHQKQVADKSEKEEKGDKTELQYARNITIERTKDYVVVRLLNPWKAGTVLHTYYLVERGKDVNVPDDGTKVVIPLRKSVIFTTAHANLVEMLHAQKAIAGVADLKYMIIPDIQKRARKRGGIVDCGDAMKPDVERIIDLNADAILLSPFENNGGYGRLEQIGVPIIECADYMERSALGRAEWMKFYGILFGREHEADSLFAVVKQNYKSLSQKASQSKVTRSVLPDRKVGAVWYLPGGESSVGLLYKDAHGRYAYSNDKHSGSLAMPFETILDKFAQSDFWILSYNSNFNRRVLLAEYQGYAKLKPYQTKEIYGCKIDSKPYFEEVSWRPDWLLSDLIQLFHPDLKIAPLRYYQKLED
>CP022041.2|ASE18451.1|751910_753377_+|dihydroorotate-dehydrogenase
MAEEKTNELGNHIEMKKVWELLAILVVTAIIWNLPTSSFGIDGLTVVQQRIIAIFVFATLSWLTECIPAWATSLSIMSIMCVTVSKNAFGVFKGDGIGELLDSKEIMASFADPIIMLFLAGFILAIAASKSGLDTLLARNLIKPFGNKSENVLLGFLLITGLFSMFISNTATAALMLTFLTPVFAALPANGKGRIALTMSIPIAANLGGMGTPIGTPPNLIALKYLNDPAGLNMNIDFMHWMAFMAPLVIVLLLLSWRIILYFFPFTQKTIHLKIDGEVHRGWRMWVVIITFIVTILLWVIPKDVTGIDTNTVSMIPMAIFAITGVITAKDMQEINWSVIWMVAGGFAIGLGMNGSGLADAAIESIPFGNWSPIVILAISGLICYFLSNFISNTATAALLVPILAVVCRGMGDKLGGIGGTSTVLIGIAIAASTAMCLPISTPPNAIAYSTGLVKQNDMLKVGLTSGVVSLILGYILLYFIGQIHFLG

Crispr_ID: CP022041_11

• CRISPR_ID: CP022041_11
• CRISPR_location: 1315103-1315206
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_11

Consensus_repeat	Method
TTGTATAGTTGGCAAGTGAACGAG	CRISPRCasFinder

spacers of CP022041_11

>11.1|1315127|56|CP022041|CRISPRCasFinder
TAAACAAGTTGCTTGTATAGTTGGCAAGTGAACGAGTTGACGAGTAAACAAGTTGC

CRISPR arrays and Neighbor proteins around CP022041_11

CRISPR arrays

The CRISPR arrays of CP022041_11

>merge|CP022041|11|1315103-1315206|CRISPRCasFinder
TTGTCAAGTAAACAAGTTGACGAGTAAACAAGTTGCTTGTATAGTTGGCAAGTGAACGAGTTGACGAGTAAACAAGTTGCTTGTGTAGTTGACAAGTGAACAGG

>CP022041|11|10|1315103-1315206|CRISPRCasFinder
TTGTCAAGTAAACAAGTTGACGAG	TAAACAAGTTGCTTGTATAGTTGGCAAGTGAACGAGTTGACGAGTAAACAAGTTGC
TTGTGTAGTTGACAAGTGAACAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18940.1|1325087_1326713_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl|CDD|372283
CP022041.2|ASE18851.1|1326719_1329830_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
CP022041.2|ASE18841.1|1306499_1308119_+|hypothetical-protein	unknown	unknown	gnl|CDD|271342
CP022041.2|ASE18836.1|1297077_1299237_-|S9-family-peptidase	unknown	unknown	gnl|CDD|224423
CP022041.2|ASE18840.1|1304752_1305565_+|PepSY-domain-containing-protein	unknown	unknown	gnl|CDD|377164
CP022041.2|ASE18852.1|1330183_1331287_-|MRP-family-ATP-binding-protein	unknown	unknown	gnl|CDD|378455
CP022041.2|ASE18847.1|1317940_1319164_+|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341202
CP022041.2|ASE18837.1|1299239_1301171_-|membrane-protein-insertase-YidC	unknown	unknown	gnl|CDD|234942
CP022041.2|ASE18854.1|1333136_1333403_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18843.1|1309772_1312529_+|T9SS-C-terminal-target-domain-containing-protein	unknown	unknown	gnl|CDD|173811
CP022041.2|ASE18939.1|1303578_1303824_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18850.1|1323951_1325070_-|endoglycosidase	unknown	unknown	gnl|CDD|119359
CP022041.2|ASE18846.1|1316250_1317927_+|N-6-DNA-methylase	unknown	unknown	gnl|CDD|280533
CP022041.2|ASE18839.1|1303820_1304546_+|KR-domain-containing-protein	unknown	unknown	gnl|CDD|187608
CP022041.2|ASE18838.1|1301171_1302782_-|CTP-synthase	unknown	unknown	gnl|CDD|235437
CP022041.2|ASE18842.1|1308155_1309757_+|hypothetical-protein	unknown	unknown	gnl|CDD|271342
CP022041.2|ASE18844.1|1312540_1313494_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18848.1|1319179_1322380_+|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl|CDD|223683
CP022041.2|ASE18849.1|1322765_1323911_-|DUF1735-domain-containing-protein	unknown	unknown	gnl|CDD|378016
CP022041.2|ASE18853.1|1331417_1331795_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18940.1|1325087_1326713_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl|CDD|372283	pfam12741, SusD-like, Susd and RagB outer membrane lipoprotein. This is a family of SusD-like proteins, one member of which, BT1043, is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologs in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	0
CP022041.2|ASE18851.1|1326719_1329830_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
CP022041.2|ASE18841.1|1306499_1308119_+|hypothetical-protein	gnl|CDD|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	6.54743e-12
CP022041.2|ASE18836.1|1297077_1299237_-|S9-family-peptidase	gnl|CDD|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	3.56837e-78
CP022041.2|ASE18848.1|1319179_1322380_+|type-I-restriction-endonuclease-subunit-R	gnl|CDD|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	4.22971e-142
CP022041.2|ASE18847.1|1317940_1319164_+|restriction-endonuclease-subunit-S	gnl|CDD|341202	cd17521, RMtype1_S_Sau13435ORF2165P_TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) TRD2-CR2, Escherichia coli E24377A S subunit (S.EcoE24377ORF286P) TRD1-CR1 and Pseudoalteromonas species P1-13-1a S. subunit (S.Psp1bORF2093P) TRD2-CR2. Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) recognizes 5'... TCTANNNNNNRTTC ... 3', and the recognition sequences of Escherichia coli E24377A S subunit (S.EcoE24377ORF286P) and Pseudoalteromonas species P1-13-1a S subunit (S.Psp1bORF2093P) are undetermined. The restriction-modification (RM) system S subunit generally consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) TRD1 recognizes TCTA/TAGA, and -TRD2 recognizes GAAY/RTTC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. In addition, this family includes RMtype1_S_TRD-CR_like domains of various putative Helicobacter type II restriction enzymes and methyltransferases, such as Hci611ORFHP and HfeORF12890P.	1.95866e-71
CP022041.2|ASE18837.1|1299239_1301171_-|membrane-protein-insertase-YidC	gnl|CDD|234942	PRK01318, PRK01318, membrane protein insertase; Provisional.	1.09405e-100
CP022041.2|ASE18840.1|1304752_1305565_+|PepSY-domain-containing-protein	gnl|CDD|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	1.27613e-34
CP022041.2|ASE18843.1|1309772_1312529_+|T9SS-C-terminal-target-domain-containing-protein	gnl|CDD|173811	cd07485, Peptidases_S8_Fervidolysin_like, Peptidase S8 family domain in Fervidolysin. Fervidolysin found in Fervidobacterium pennivorans is an extracellular subtilisin-like keratinase. It is contains a signal peptide, a propeptide, and a catalytic region. The tertiary structure of fervidolysin is similar to that of subtilisin. It contains a Asp/His/Ser catalytic triad and is a member of the peptidase S8 (subtilisin and kexin) family. The catalytic triad is similar to that found in trypsin-like proteases, but it does not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	1.25562e-83
CP022041.2|ASE18850.1|1323951_1325070_-|endoglycosidase	gnl|CDD|119359	cd06542, GH18_EndoS-like, Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain. Some members also have an additional C-terminal glycosyl hydrolase family 20 (GH20) domain while others have an N-terminal domain of unknown function (pfam08522). Members of this family include endo-beta-N-acetylglucosaminidase S (EndoS) from Streptococcus pyogenes, EndoF1, EndoF2, EndoF3, and EndoH from Flavobacterium meningosepticum, and EndoE from Enterococcus faecalis. EndoS is a secreted endoglycosidase from Streptococcus pyogenes that specifically hydrolyzes the glycan on human IgG between two core N-acetylglucosamine residues. EndoE is a secreted endoglycosidase, encoded by the ndoE gene in Enterococcus faecalis, that hydrolyzes the glycan on human RNase B.	3.54753e-38
CP022041.2|ASE18846.1|1316250_1317927_+|N-6-DNA-methylase	gnl|CDD|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	1.95381e-85
CP022041.2|ASE18839.1|1303820_1304546_+|KR-domain-containing-protein	gnl|CDD|187608	cd05350, SDR_c6, classical (c) SDR, subgroup 6. These proteins are members of the classical SDR family, with a canonical active site tetrad and a fairly well conserved typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	3.73694e-47
CP022041.2|ASE18838.1|1301171_1302782_-|CTP-synthase	gnl|CDD|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
CP022041.2|ASE18842.1|1308155_1309757_+|hypothetical-protein	gnl|CDD|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	3.84982e-16
CP022041.2|ASE18852.1|1330183_1331287_-|MRP-family-ATP-binding-protein	gnl|CDD|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	1.83825e-134
CP022041.2|ASE18849.1|1322765_1323911_-|DUF1735-domain-containing-protein	gnl|CDD|378016	pfam08522, DUF1735, Domain of unknown function (DUF1735). This domain of unknown function is found in a number of bacterial proteins including acylhydrolases. The structure of this domain has a beta-sandwich fold.	2.2566e-16

Protein sequences

>CP022041.2|ASE18844.1|1312540_1313494_+|hypothetical-protein
MNTKHIILMACAALLGATQANAQGQDLSILTANTDARTAAMGNASAAAEGMYLYNNPAAFFATDKKFTADASASLFEKAEGADGTFGIYALSAGYKLAKRHAVFVGFRYAGGLSLKGSDLLGNPTKDYKPYNWTLDLGYTYFLGKGFATYATGSLIYSHLSKNATGAVFSVGGAYQNNELTLANKPANLMLDAKVGAIGPQLDYGNKHKTTLPTYLAVGGALSVEVAEKHQVAAALSSRYFFQPSEAKLFMLGGGLEYTYNKMVSVRAGYEYGDHDLSHVTMGAGFKYHGLRLNGAYNLKTADTGSSYCTIGIGYDF
>CP022041.2|ASE18843.1|1309772_1312529_+|T9SS-C-terminal-target-domain-containing-protein
MRKSIIYLCACALSGMMVTTSCQDNLDSDAGVSNTRSVNIDKDLFAIKGCINVKLAKGTNQAIPTTRSGSVEMQSVPSAMTSAMQYSGAYKMERVFKPAGIYEARTVAEGLDRWYTIYFDKSKDVAAVLDQFKKAEGVECAEQVLPMARPTVKMTPYSPSGASMQATASTFDDPLLAKQWHYYNDGSVNARAKKGADCNVKPVWEKYTTGKKNVIVAVVDGGIDITHEDLKDNLYVNEKEKNGQPNVDDDGNGFVDDIYGYNFVTAKDVVGGTIEPDDGGHGTHVAGTVAARNNNGKGVAGIAGGDGSPDSGVRLLSCQIFRNKDEQGDAAAAIKYAADNGAVICQNSWGYSSTAGVTSMPQLLKEAVDYFIKMAGCDANGNQRPDSPMKGGVVMFAAGNENKEFSAYPACYAPTVSVAAMAWDFSKASYSNYAKWVTITAPGGDQDRFGTEAGVLSTVPKKKVASGYAYFQGTSMACPHVSGIAALIASYFGRQGFTNEELKSRLITAYRPYNIDEQNPTYKGKLGKGYIDAEAAFETDTKIAPEKVGTLTLKPDFVDINAEWSIAKDEDKTAAFYRLYIAQGELTADKLKDMTYREINGMGHSLGETLKYDFDDLKDNTTYSVAVVAVDRWGNLSEPMIQKCTTRLNHAPEATNFPTEAIEVMENDRKSFSFNVADPDGHNWDIKATGETKGVSYTVKGNTVTVNLVPVLEAGSYNCTFILSDDLGAKAEKSFTFKIVKYIPPQLTKPFENYIIGLDEGVVTIPLTGHYTHSGNTQLTYKATAANGSIATATISNDNLQLKGMAKGVTRISIAATDGRETSSDGSFQVRVVEKKSAPVYAVYPIPVQRDIHTLLNPEVKQAELVISSTVGERLMKATVTPDKNNVATLDLSKLNPGTYKLTVYTSKGNHTQMFIKR
>CP022041.2|ASE18842.1|1308155_1309757_+|hypothetical-protein
MRIINIHKLLQFSLLYLLLGIAVGCAENDSFDQPYLNVSEKEISFSNQIGEKTITVNTNCKEWMATTPKAWVHLSQSGNEIAVHVDPNTTGMERSSYILVDGGLAVQKIMVSQSAADITLNLNNGEVILPQAGGTTTVDLKMDATSYDLTQSEQPEWMQVIKKKHGLKFISKPNYSTTERTTKLTIAFAGKNHEVVVKQPGVATFILACNPGNPYSLHKMMDYEYRRGSFLTEYGGPDEVNGIFEESYFFKTPSPLFKDVVYVHDTKHSVPTRIYTRSLTREGVNAVKSQAFQEFMRANGYTRDEKDTNHYVNIKEAFTMDVDIREENNSVVLFFYQMHTQDRSYPTFSSLDLGPVDLLNKTDKKISDVEAYETGKNSEEMKRQMSKSNEVEAILYKTNDPTLIARTYFFYLHNDAAVPQEKAGSVEQYSLFYSQPNLGIWQYGNEWFVTHEFDKLLTANNFEFVGYNGKHHVYARRSDYLTLAISGGEYADVNNGKAVMQITVLYKPTVFAGSKEQRLAKVERMLKQYNPKK
>CP022041.2|ASE18841.1|1306499_1308119_+|hypothetical-protein
MELKKTLYSLMLGGILLCLFSCAKEDEFEMPTLVLSENSIAFDKGVSERNISVTTNQNSWIASSPQEGDWLSLVQDGNVLKVKVTENKIGTERTSYVLVNANGASGKIAVTQSAADVTLDVVPNAIYLPQTGGEKTIDITTNSSVYDVTTSEEVSWLKIVKSEEEIKLIAERNDTYQKREVKLYAKSGSVIREIVVSQSGIQRYLLPIHPGVPQDEHKIMDFELGRGSYLREYQAAMPAYGLEETYTFITASPIFTLIQYCSTDGINPSQIIMIGDGRKAIDAVKDKAFDKFLTDNGYVRSNSQSDREYTNDKDLLSLKVYISEKENNEGVNLTFTPIMKQNGEYKTFSKLPFYPLELLQKDNVKLAQIEQYEQKAGSTEEERSLNEHKNTEVSQIQYKLKASTDPSAAYGRIHIFYTTDKDGDAPDNLGSVQIGALLFKDTNLGVWKYGTKWVATKEIKKVLGDEGFSFLRTSGNNHFFVRESDHLVIDVTCVLDNAMPVLALLYSYDPSVSGASSKAIKTQAKMIRNFAAAKKALKF
>CP022041.2|ASE18840.1|1304752_1305565_+|PepSY-domain-containing-protein
MRKFCLKIHRWFALPLGVIMAILCFSGLAILLIKDLAPLFDMNAKEMPIYTIVVRLHRWLFMKPENAHEGGQSLGRILTAVSAICMSIVLLSGVVIWWPKTKKALKSRLTVSTNKGFRRFVYDSHVSLGIYVFIFLFLMALTGPVFSFGWYRAGMSKLFGQPMPPKEMKMQQPKDGMKQGGTNDKAFAPTDASQMKGQPQAHKEGAKDMKGDQHGKKPKGGKLFKQLHTGTWGGWFSRVLYAIAALIGGFLPISGYYLWWKRRSAKKKKA
>CP022041.2|ASE18839.1|1303820_1304546_+|KR-domain-containing-protein
MKKAIVVGASSGIGHEVARLLIAEGWAVGVAARRIDKLTDLQAMAPERVYTVQIDVTNEDAETSLLQLIERMNGIDLYFHAAGIGWQNPSLNADIELKTMETNAVGFTRMIGCAYRYFANKGGGHIACITSIAGTKGLGPAPAYSATKAMQNTYLQALEQLAACKHHNIHFTDIRPGFVDTPLLAGTSHLPMLMTTKKVARSIIKAINSRRHICVIDSRWCVLTYLWRHIPNWIWRRMKLC
>CP022041.2|ASE18939.1|1303578_1303824_+|hypothetical-protein
MELDTTNMCSHLQKKLFNEEGVYYPIWQAMQNDDEITAVIRSRQLHIYRNGKKVLVLPGKAAPKIIREDSLNELLPKDLLK
>CP022041.2|ASE18838.1|1301171_1302782_-|CTP-synthase
MAETKYIFVTGGVVSSLGKGIISSSIGKLLQARGYNITIQKFDPYINIDPGTLNPYEHGECYVTEDGMETDLDLGHYERFTGIKTTKANSMTTGRIYKSVIDKERRGDYLGKTIQVVPHITDEIKRNIKLLGQKYHYDFVITEIGGTIGDIESAPFLEAIRQLKWELGKRAINLHLTYVPYLKAAGELKTKPTQHSVKELQSVGIQPDVLVMRTEKHLDDDIRKKVAAFCNVDFDCVVQSEDLPSIYDVPVNMLEQGLDAAILRKCGEEVGPKPALGPWKEFLDRQRKATKEVHIGLVGKYDLQDAYKSIREGLLQAGTYNDRKTVITFINSEELTEENVAEKLKGQDGIVICPGFGQRGIEGKIVAAHYTRTHDIPTFGICLGMQMMVIEFARNVLGYKDANSREIDEKTTHNVIDIMEEQKNITNMGGTMRLGAYECVLRQGSHTFNIYKQEHIQERHRHRYEFNNDYEKEFEKHGMMCVGRNPESDLVEIVEIPGLKWYIGTQFHPEYQSTVLGPHPLFLDFVKTSIENQKNK
>CP022041.2|ASE18837.1|1299239_1301171_-|membrane-protein-insertase-YidC
MDKRTITGFVLIALILFGFAWWQQPSAEQVAQQRAEFVKDSIASAKKAQTAKLAAEKQAQQKAAQATDTTALFYAALNGKAQDIILKNSKVELTLSTKGGVVKKAVIKNYIGHNIAVKDGSQDQKNVTLFSGDDQSLNFMLAAKNSNIETKDLIFTPSNVTDSTVTLTAVAGEGKTLTLNYTLGKDYLLNMSLQAEGMGGLFAPNYNQIDINWQERCKQQERGFTFENRYATLTYKKHDGGTDYLSETSEKEETTEDSMDWVAFKNQFFSAVMIAKDNFATGAKLKSTPLEKSSHYLKHYEANMKAGFDPTGKRPSEFEFYFGPNDFRLLQSVETESKFAKELDMERLVYLGWPLFRIINRWFTLYVFDWLSKVFPMGVVLILITLLLKLITFPMVKKSYMSSAKMRVLKPKLDEATKQFNKPEDQMQKQQAMMQKYSEYGVSPLSGCLPMLIQMPIWIAMFNFVPNAIQLRGQSFLWMHDLSTFDPIFSWSHDVWLVGDHISLTCILFCGANLLYTWFTMQQQKDQMVGQQADQMKMMQWMMFGMPLFFFFMFNDYSSGLNFYYFISLFFSAAIMWALRKTTNEEKLLAILEARREERKNNPKNNMGSGLFARMQALQELQKQQQEELRRKQDELNKKKKGL
>CP022041.2|ASE18836.1|1297077_1299237_-|S9-family-peptidase
MNKNLTMAMTAALMMSGSVAQAQDVNIGRSNITLTSDLMTPETLWAMGRIGAAQASPDGKKIVYQVGYYSVKENKGHQVLRVMDADGKNDRLLTTSAKSEGDAAWVDNNTLAFLTGGQLWTMNADGTNRKQLTHSDIDIEGFRFSPDRKRVVLIKSIPYYGTIKQNPSDLPKATGMVITDMNYRHWDHYVTTNAHPFVADVTPEGIGAGIDVLEGEPYESPLAPFGGIEQIDWSKDSKFIAYTCRKKEGTQYAISTDADIYIYNVETRQTKNLCKPADYVEPKIDATKSMRNQAVNHQAGDMNVGYDVNPKFSPDGKYIAWQSMKNDGYESDRNRLCVYELATGKKTYVAESFDSNVDDYTWSLNSKDLYFIGVWHATVNVYQTNLKGEVKQLTEGDHNYVSISLLGDKKLLAIRQSISQANEIFAITPAKKEKASVQTQLSFENKHIYDQLALGDVKSRWVKTTDGKEMMEWVITPPHFDPNKKYPTLLFCEGGPQSPVSQFWSYRWNFQIMAANGYVIIAPNRRGLPGFGSAWNEEVSTDWTGQCMNDYLSAIDDAANNLSFVDKDRLGAVGASFGGFSVYYLAGIHNKRFKCFISHDGAFNLESMYTDTEEAWFSNWEYDDAYWNKDKSEAAKRTYANSPHLNVDKWDTPILCIHGEKDYRINANQGMGAFNAARLRGIPAELLLYPDENHWVLKPQNSVLWQRTFFNWLDRWLKK
>CP022041.2|ASE18846.1|1316250_1317927_+|N-6-DNA-methylase
MTSTELKDLEGRLWQSADMLRAGAHLAANKYSQPILGLIFLRYADVLFKQHKEAIDTAYNEYKGTRMERSYKDIAIEKCGFFLPECAYFDYLNDAPDDAQKALLVKAAMEAIEHENPRMDGVLPKEVYGQLVPEEEPELLSRIVRVFKDIPENISIDIFGQIYEYFLGNFALAEGQGGGAFYTPASVVQYMVEVLQPATGDKKFLDPACGSGGMFVQAARYMHRHNTSNEQMMNFRCYGVEKEPDTVKLAKMNLLLNNVRGEIMEANSFYSDPYNAVGQFDYVMANPPFNVDEVVVERVTDDARFNTYGVPRNKTKSAKKASDKKETVPNANYLWIGYFATALNEQGKAALVMANSASDAGGSELEIRKKMIEDGIISQMVTLPSNMFSTVTLPATLWFFNKKRPKKDEILFIDARNIFTQVDRAHRKFSDEQVKNLGIISRLYEGDSDAFWALVEEYKAEGKQSEADWLLERWPDGKYQDIVGLCKVAKLEGEDGIIDNDYSLNAGRYVGVVIEDDGMTEEEFRTEMLSLNSEFAKLSAEAKDLESEIEKNLKELLG
>CP022041.2|ASE18847.1|1317940_1319164_+|restriction-endonuclease-subunit-S
MEYVKFKDVIINSQYGYTATETSQTEGTYKYLRITDIVPYYVNFDTVPFCKITEKDVSKYIVKEGDILIARTGATTGYNYVVPSGISNTVYASYLIRFIVDKKLVLPLFMKYVLKTQSYYGFINNYIGGSAQPGMNAKVFTKFNIPKLSLVTQQKIASILSSYDRLIENNTRRIRLLEQMAENLYKEWFVRFRFPEHENVEIVNGLPKGWKTIHIKELAQLKSGYAFKSEWFVEEGEAVAKIKDIGNILMDTSNFSYVDKENCIKAKKFLLTTGDLTIALTGATIGKISIVPKHKGNIYTNQRLGKFFLGDNPMEKLPFLYCLFKQESMVSNIVNLSNSSSAQPNISPEQIEKIKILGNHDIISMYNKTCNPLFSNILALYSQNQLLTRQRDLLLPRLMSGKLEVKS
>CP022041.2|ASE18848.1|1319179_1322380_+|type-I-restriction-endonuclease-subunit-R
MKSFISEDDIEQTLCTRLSQPEFGWKRIECDPSVEAQDDVSKTGRRNSSECILPAVFLTALERLNPQIDKSILAQVVADFRKDYTGKDMMDTNYKFYNYLRNGINVKVKKNGKDDFDIVRLIDFDNVENNDFHCVNQMWIKGRIRYRRPDVLLFVNGLPMVFIELKNSTVKIKEAYEKNLVSYREDIPNIFALNQICVLSNGMQTKLGAWNSKYEFFFDWLKVNDEHEKLDREHIAEYGLSIINLIDSLFRKERLLDYIENFIFFDNKRKKIIAKNHQYLGVNNLMKSVECREELKGKLGVFWHTQGSGKSYSMVMFVRKVRRKLKGNFTFLVITDRDDLDTQIHKTFVRSEVIGEKEECQPKNAAQLREFLSGNKPMVFTLIHKFQYDKTKKYPLLSERNDIFVLVDEAHRTQYKQLAENMHTGLPNANYIAFTGTPLLGSKRLTNQWFGDYVSEYNFAQAIEDGSTVRLYYSRRVPEVGLENNWLDSDIDKIVEEEELNDRERELLENSSSRILEVIKRDGRLDRIAQDIAHHFPRRGFLGKGMVVSVDKYTAVKMYEKVQHYWGEEKKALIKERNAAKTQEERDELTARLDYMNKVEMAVIISEEADEVEKFKAQGLDITVHRNKMNEITPEGKDIEDRFKDKDDPLSLVFVCAMWLTGFDVPSLSTLYLDKPMKGHTLMQAIARANRVYPGKSCGIVVDYVNVFKYMQQALSDYASNGEEGAEFPAKDITQLIATIDGCIEECDSFLQGLGIRLDKIITDGDTLDKLESLRLAYDKILEKDESKNRFKVMSNLMMNLHDAAKPEIFELGWKNEKFSPLSYLNGLFCNRIDDEKLRRAKEKMSYTLDDSVTVMVAEDKPQYSIHQSKVIDLSKLDIESIRKSINATPYKSMEIDNLRTFIETALEQLINKNCTRVPFSQRYKNIIDTYNAGGTENEDYYEKLLQLIDELKKEQGRSADMGLREEELEIYDLLIQGRKLTKEEEKEVILASKNLYNKLVEEKERLLVVDWYKDPQPKTKVLGLIQRSLDKDLPKTYDREVFSNKTNLLLDHFVDMAVQGYGWIS
>CP022041.2|ASE18849.1|1322765_1323911_-|DUF1735-domain-containing-protein
MNKHIFKHIAVAFAACCVVSCQDSESDLLKQKVYFDSNLYKVEMPDSGSTLGVDITSRLSNKQDGAVDVSYSLADSSLVALYNSKYGTDYVALKHQNVTFSKASSTIAAGSIYADKVSLTLNNLDQLAEGKNYMLPIKLHSSSTPVIDGEDVEYIILAKPVKITKAGDFYNKYISVKFPAGTYFKSFTYEALVHSIWWGSNCTIMGSEGLMIFRVGDVGGGISSGILQAAGRQHYEAPEKLSINKWYHVALTYDQATGKTVMYLNGTKWAESAWNISGFDPNADVGFNIGKIPGFPWGERPFYGYMSEVRVWSVARSENQIKQNMLSVDPKSDGLELYFKLNGSETVNGNKIKDSAKGIECTTGGLEFTTLAQPLTMKDLQ
>CP022041.2|ASE18850.1|1323951_1325070_-|endoglycosidase
MKNFKYISSLVLLCAGVLFCGCSKMTEVENEPYDHIGGYNTMNNAESEKYYADLRAYKQQAVNYGRPVAFGWYSNWSPAGTYRRGYLTSMPDSMDVVSMWSGAPNRFNITPEQKKDKEFVQKVKGTKLLEVTLLSYIGKGRTPDSVYTAVEKQAEKEGWANDQARVEEAKKKARWKFWGYEGVAGSDNHKEALARFAKALCDSLVANDWDGYDIDWEIGSGVFDMDGTLSTNADLVYLVKEMNKYIGPKSDPEHKGHRLICIDGHFGGLTEDLDGYVDYWIDQAYGRTTHFDYYGVDPKTIITTDNFESSFKSGGQLLRQAKSMPSKGYKGGVGAYRFDNDYDNTPNYKWMRQAIQINQQVFKERMGQTTQP
>CP022041.2|ASE18940.1|1325087_1326713_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MKTKAYKYIVGVLALSLFTACDFQKVNTNEFELLPEEGLMDGISIGGPITAMQKCVFPVGTQADGTSVANRYQTAYNLAADCWSGYFGQNNNWGGPNNLNYFLKDGWVASSYTESYSTVVPLWQDLKGKTETQFPEVFALAQILKISAWHKATDMFGPIPYKEAGKGLITVPYDSQEEVYKAMFKELSDAIEVLTKYADNGNSKLLPNADAVYAGDVHKWVVYANSLMLRLAMRVYYADAALSKKYALQAVNHSYGVMKTKDDEAKMERGASLEFKNNLDVLINQYNECRMGSSMLAYLGGYQDPRLPKYFNTSTVSQAVTVGTYGKYSGVPTGHDVSSNDAFRDSSRPAITSTTPTYWMRASEVYFLLAEAALHGFAVGGTAESLYEKGIEMSFEENGIASSEVADYMSSGLKPSAYSFHLTNPGVNVDVPAVTEATTAWSGTDEEKLEKIMIQKWIALYPNGQEAWTEYRRTGYPKLHSVVTNYSNGEIDSEVGIRRMRFPTNKSTSAEDIANLESARKLLRGGLDKAGTRLWWDNKNH
>CP022041.2|ASE18851.1|1326719_1329830_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MRMIHETKQKHLYFSVAFALSIALAPTSVYAVGNPVGSPDASMPQAVQQNGNHKVTGRVVDSAGEPLIGATIMVEGTKEGAVTDIDGNFTINTTSKAKLVISYVGYTTQTIPVGDKTTIDVTLKEVANTMNEVVVTALGIKRAEKALSYNVQSVGSNELTRNKDANFVNSLNGKVAGVSISKSASGVGGATRVIMRGAKSIEGDNNVLYVIDGIPIFNFSGGRDSGIMGEGRVSSEGIADLNPEDIESISVLAGPSAAALYGSNAANGAILITTKKGKEGRVDISFSSSADFSSPLLMPKFQNTYGNKLGSYESWGEKLATPSSYDPKKDFFRTGTNFINALTLNMGNEFNQTFASVATTNSRGIVPNNTYDRYNFTIRNTTRMFKNRVQLDLGASYIKQKDNNMVSQGEYWNPIVAAYLFPRGESFEGIKTFERYDNVRNFPTQYWPISDSRFANQNPYWTAYRNLAPDDKDRFMFNAGLTYNIFDWLSVAGRIRLDKTFITSERKIYASSFNYFAKEKGAYDYYDYKDHQTYIDAIANINKTFGKFSLAANVGYSYSDYASLTRGYGGNLVLVPNKFSLNNINPTDSKIREAGGDSKVRNVAAFASAELGWRSMVYLTLTGRNDWNSRLVNSSEESFFYPSVGLSGIISEMTKLPSFISYLKVRGSYTEVGSPVSRSGMTPGTITTPIVGGSLKSTDIYPFTDYKAERTKSYEFGLTARFWKKLSFDFTWYKSNTYNQTFIGELPESSGYKAVYLQAGNVENRGVEMALGYSDNFGGLQWNSSLVYSKNVNEIKEMVKDYHHPLSPKPINIPEVSKDNGRVLLKVGGSINDIYARKVLAKDNQGFVNVSPSGGMNLETVEPIYLGKTTPDFTMGWNNNFTYKNFGLSFLINARVGGIVTSSTQALLDRFGVSKASADARDAGGVMIPNQGLYDAKKYYTLVATGENDLAGYYTYSATNVRLQELTLSYKFNSKLFNNVIKDLTLSFVATNPWMIYCKAPFDPELTASTGTYGQGNDYFMQPSLKSYGFSVKFKF
>CP022041.2|ASE18852.1|1330183_1331287_-|MRP-family-ATP-binding-protein
MTLYPKLITDALEKVIYPGTKKNIIESEMLADTPSINGNKVSFTLIFPRETDPFLKSTIKAAEAQIHYSVGKEVEVTITTEFKNAPRPEVGKLLPQVKNIIAVSSGKGGVGKSTVSANLAIALARLGYKVGLLDTDIFGPSMPKMFGVEDARPYGVEKDGRQLIEPVEKYGVKLLSIGFFVNPDTATLWRGSMATSALKQLIADADWGELDYFILDTPPGTSDIHLTLMQTLAITGAVIVSTPQNVALADARKGIDMYRNDKVNIPILGLVENMAWFTPAELPENKYYIFGKDGCKNLAKELGCPLLAQIPIVQSICENGDNGTPAASQVDTITGQSFLSLAQSVVTVVNRRNKEQAPTKIVDVKNG
>CP022041.2|ASE18853.1|1331417_1331795_-|hypothetical-protein
MGRNKFAEDEIKEIAKLLRLKNAGNRAKQKLVRHDLRTIYEFNISDFNEPGKAFGEEELQGAIQRGAIQILDDATIADMKAKRARDKARDEATREQQAIEAGEMTDWKAVAKEWEEWENSQNNGN
>CP022041.2|ASE18854.1|1333136_1333403_+|hypothetical-protein
MRQAISIIVLYALINILSLLFNIISFSTDGKIDIGFPFIFIHLTSAKYDPTFPYNKLLIEPFLWDIIFLFTIVCLYLCCLKFIKRIRD

Crispr_ID: CP022041_12

• CRISPR_ID: CP022041_12
• CRISPR_location: 1322540-1322693
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022041_12

Consensus_repeat	Method
AAAACTCATATCATAAAGTTCAAAGTTCAAACATCAA	CRISPRCasFinder

spacers of CP022041_12

>12.1|1322577|80|CP022041|CRISPRCasFinder
TGTTCAAAGGATAAAAAACTCATATCATAAAGTTCAAAGTTCAAACATCAATGTTCAAAGGATAAAAGAGTTCAAAGGAT

CRISPR arrays and Neighbor proteins around CP022041_12

CRISPR arrays

The CRISPR arrays of CP022041_12

>merge|CP022041|12|1322540-1322693|CRISPRCasFinder
AAAACTCATATCATAAAGTTCAAAGTTCAAACATCAATGTTCAAAGGATAAAAAACTCATATCATAAAGTTCAAAGTTCAAACATCAATGTTCAAAGGATAAAAGAGTTCAAAGGATAAAACTCATATCATAAAGTTCAAAGTTCAAACCTCAA

>CP022041|12|11|1322540-1322693|CRISPRCasFinder
AAAACTCATATCATAAAGTTCAAAGTTCAAACATCAA	TGTTCAAAGGATAAAAAACTCATATCATAAAGTTCAAAGTTCAAACATCAATGTTCAAAGGATAAAAGAGTTCAAAGGAT
AAAACTCATATCATAAAGTTCAAAGTTCAAACCTCAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022041.2|ASE18940.1|1325087_1326713_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	unknown	unknown	gnl|CDD|372283
CP022041.2|ASE18851.1|1326719_1329830_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	unknown	unknown	gnl|CDD|274948
CP022041.2|ASE18841.1|1306499_1308119_+|hypothetical-protein	unknown	unknown	gnl|CDD|271342
CP022041.2|ASE18857.1|1335636_1335981_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18840.1|1304752_1305565_+|PepSY-domain-containing-protein	unknown	unknown	gnl|CDD|377164
CP022041.2|ASE18847.1|1317940_1319164_+|restriction-endonuclease-subunit-S	unknown	unknown	gnl|CDD|341202
CP022041.2|ASE18853.1|1331417_1331795_-|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18839.1|1303820_1304546_+|KR-domain-containing-protein	unknown	unknown	gnl|CDD|187608
CP022041.2|ASE18843.1|1309772_1312529_+|T9SS-C-terminal-target-domain-containing-protein	unknown	unknown	gnl|CDD|173811
CP022041.2|ASE18854.1|1333136_1333403_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18850.1|1323951_1325070_-|endoglycosidase	unknown	unknown	gnl|CDD|119359
CP022041.2|ASE18846.1|1316250_1317927_+|N-6-DNA-methylase	unknown	unknown	gnl|CDD|280533
CP022041.2|ASE18848.1|1319179_1322380_+|type-I-restriction-endonuclease-subunit-R	unknown	unknown	gnl|CDD|223683
CP022041.2|ASE18842.1|1308155_1309757_+|hypothetical-protein	unknown	unknown	gnl|CDD|271342
CP022041.2|ASE18845.1|1313538_1315113_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18844.1|1312540_1313494_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18852.1|1330183_1331287_-|MRP-family-ATP-binding-protein	unknown	unknown	gnl|CDD|378455
CP022041.2|ASE18855.1|1333821_1334337_+|hypothetical-protein	unknown	unknown	unknown
CP022041.2|ASE18849.1|1322765_1323911_-|DUF1735-domain-containing-protein	unknown	unknown	gnl|CDD|378016
CP022041.2|ASE18856.1|1335329_1335629_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022041.2|ASE18940.1|1325087_1326713_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein	gnl|CDD|372283	pfam12741, SusD-like, Susd and RagB outer membrane lipoprotein. This is a family of SusD-like proteins, one member of which, BT1043, is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologs in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	0
CP022041.2|ASE18851.1|1326719_1329830_-|SusC/RagA-family-TonB-linked-outer-membrane-protein	gnl|CDD|274948	TIGR04056, OMP_RagA_SusC, TonB-linked outer membrane protein, SusC/RagA family. This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate].	0
CP022041.2|ASE18841.1|1306499_1308119_+|hypothetical-protein	gnl|CDD|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	6.54743e-12
CP022041.2|ASE18840.1|1304752_1305565_+|PepSY-domain-containing-protein	gnl|CDD|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	1.27613e-34
CP022041.2|ASE18847.1|1317940_1319164_+|restriction-endonuclease-subunit-S	gnl|CDD|341202	cd17521, RMtype1_S_Sau13435ORF2165P_TRD2-CR2_like, Type I restriction-modification system specificity (S) subunit TRD-CR, similar to Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) TRD2-CR2, Escherichia coli E24377A S subunit (S.EcoE24377ORF286P) TRD1-CR1 and Pseudoalteromonas species P1-13-1a S. subunit (S.Psp1bORF2093P) TRD2-CR2. Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) recognizes 5'... TCTANNNNNNRTTC ... 3', and the recognition sequences of Escherichia coli E24377A S subunit (S.EcoE24377ORF286P) and Pseudoalteromonas species P1-13-1a S subunit (S.Psp1bORF2093P) are undetermined. The restriction-modification (RM) system S subunit generally consists of two variable target recognition domains (TRD1 and 2) and two conserved regions (CR1 and CR2) which separate the TRDs. The TRDs each bind to different specific sequences in the DNA. For example, Staphylococcus aureus NCTC 13435 S subunit (S.Sau13435ORF2165P) TRD1 recognizes TCTA/TAGA, and -TRD2 recognizes GAAY/RTTC. RM systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The host genome is protected from cleavage by methylation of specific nucleotides in the target sites. In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity (S) subunit (this family), two modification (M) subunits and two restriction (R) subunits. This model contains both TRD1-CR1 and TRD2-CR2. In addition, this family includes RMtype1_S_TRD-CR_like domains of various putative Helicobacter type II restriction enzymes and methyltransferases, such as Hci611ORFHP and HfeORF12890P.	1.95866e-71
CP022041.2|ASE18839.1|1303820_1304546_+|KR-domain-containing-protein	gnl|CDD|187608	cd05350, SDR_c6, classical (c) SDR, subgroup 6. These proteins are members of the classical SDR family, with a canonical active site tetrad and a fairly well conserved typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	3.73694e-47
CP022041.2|ASE18843.1|1309772_1312529_+|T9SS-C-terminal-target-domain-containing-protein	gnl|CDD|173811	cd07485, Peptidases_S8_Fervidolysin_like, Peptidase S8 family domain in Fervidolysin. Fervidolysin found in Fervidobacterium pennivorans is an extracellular subtilisin-like keratinase. It is contains a signal peptide, a propeptide, and a catalytic region. The tertiary structure of fervidolysin is similar to that of subtilisin. It contains a Asp/His/Ser catalytic triad and is a member of the peptidase S8 (subtilisin and kexin) family. The catalytic triad is similar to that found in trypsin-like proteases, but it does not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	1.25562e-83
CP022041.2|ASE18850.1|1323951_1325070_-|endoglycosidase	gnl|CDD|119359	cd06542, GH18_EndoS-like, Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain. Some members also have an additional C-terminal glycosyl hydrolase family 20 (GH20) domain while others have an N-terminal domain of unknown function (pfam08522). Members of this family include endo-beta-N-acetylglucosaminidase S (EndoS) from Streptococcus pyogenes, EndoF1, EndoF2, EndoF3, and EndoH from Flavobacterium meningosepticum, and EndoE from Enterococcus faecalis. EndoS is a secreted endoglycosidase from Streptococcus pyogenes that specifically hydrolyzes the glycan on human IgG between two core N-acetylglucosamine residues. EndoE is a secreted endoglycosidase, encoded by the ndoE gene in Enterococcus faecalis, that hydrolyzes the glycan on human RNase B.	3.54753e-38
CP022041.2|ASE18846.1|1316250_1317927_+|N-6-DNA-methylase	gnl|CDD|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	1.95381e-85
CP022041.2|ASE18848.1|1319179_1322380_+|type-I-restriction-endonuclease-subunit-R	gnl|CDD|223683	COG0610, COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms].	4.22971e-142
CP022041.2|ASE18842.1|1308155_1309757_+|hypothetical-protein	gnl|CDD|271342	cd14948, BACON, Bacteroidetes-Associated Carbohydrate-binding (putative) Often N-terminal (BACON) domain. The BACON domain is found in diverse domain architectures and accociated with a wide variety of domains, including carbohydrate-active enzymes and proteases. It was named for its suggested function of carbohydrate binding; the latter was inferred from domain architectures, sequence conservation, and phyletic distribution. However, recent experimental data suggest that its primary function in Bacteroides ovatus endo-xyloglucanase BoGH5A is to distance the catalytic module from the cell surface and confer additional mobility to the catalytic domain for attack of the polysaccharide. No evidence for a direct role in carbohydrate binding could be found in that case. The large majority of BACON domains are found in Bacteroidetes.	3.84982e-16
CP022041.2|ASE18852.1|1330183_1331287_-|MRP-family-ATP-binding-protein	gnl|CDD|378455	pfam10609, ParA, NUBPL iron-transfer P-loop NTPase. This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.	1.83825e-134
CP022041.2|ASE18849.1|1322765_1323911_-|DUF1735-domain-containing-protein	gnl|CDD|378016	pfam08522, DUF1735, Domain of unknown function (DUF1735). This domain of unknown function is found in a number of bacterial proteins including acylhydrolases. The structure of this domain has a beta-sandwich fold.	2.2566e-16

Protein sequences

>CP022041.2|ASE18848.1|1319179_1322380_+|type-I-restriction-endonuclease-subunit-R
MKSFISEDDIEQTLCTRLSQPEFGWKRIECDPSVEAQDDVSKTGRRNSSECILPAVFLTALERLNPQIDKSILAQVVADFRKDYTGKDMMDTNYKFYNYLRNGINVKVKKNGKDDFDIVRLIDFDNVENNDFHCVNQMWIKGRIRYRRPDVLLFVNGLPMVFIELKNSTVKIKEAYEKNLVSYREDIPNIFALNQICVLSNGMQTKLGAWNSKYEFFFDWLKVNDEHEKLDREHIAEYGLSIINLIDSLFRKERLLDYIENFIFFDNKRKKIIAKNHQYLGVNNLMKSVECREELKGKLGVFWHTQGSGKSYSMVMFVRKVRRKLKGNFTFLVITDRDDLDTQIHKTFVRSEVIGEKEECQPKNAAQLREFLSGNKPMVFTLIHKFQYDKTKKYPLLSERNDIFVLVDEAHRTQYKQLAENMHTGLPNANYIAFTGTPLLGSKRLTNQWFGDYVSEYNFAQAIEDGSTVRLYYSRRVPEVGLENNWLDSDIDKIVEEEELNDRERELLENSSSRILEVIKRDGRLDRIAQDIAHHFPRRGFLGKGMVVSVDKYTAVKMYEKVQHYWGEEKKALIKERNAAKTQEERDELTARLDYMNKVEMAVIISEEADEVEKFKAQGLDITVHRNKMNEITPEGKDIEDRFKDKDDPLSLVFVCAMWLTGFDVPSLSTLYLDKPMKGHTLMQAIARANRVYPGKSCGIVVDYVNVFKYMQQALSDYASNGEEGAEFPAKDITQLIATIDGCIEECDSFLQGLGIRLDKIITDGDTLDKLESLRLAYDKILEKDESKNRFKVMSNLMMNLHDAAKPEIFELGWKNEKFSPLSYLNGLFCNRIDDEKLRRAKEKMSYTLDDSVTVMVAEDKPQYSIHQSKVIDLSKLDIESIRKSINATPYKSMEIDNLRTFIETALEQLINKNCTRVPFSQRYKNIIDTYNAGGTENEDYYEKLLQLIDELKKEQGRSADMGLREEELEIYDLLIQGRKLTKEEEKEVILASKNLYNKLVEEKERLLVVDWYKDPQPKTKVLGLIQRSLDKDLPKTYDREVFSNKTNLLLDHFVDMAVQGYGWIS
>CP022041.2|ASE18847.1|1317940_1319164_+|restriction-endonuclease-subunit-S
MEYVKFKDVIINSQYGYTATETSQTEGTYKYLRITDIVPYYVNFDTVPFCKITEKDVSKYIVKEGDILIARTGATTGYNYVVPSGISNTVYASYLIRFIVDKKLVLPLFMKYVLKTQSYYGFINNYIGGSAQPGMNAKVFTKFNIPKLSLVTQQKIASILSSYDRLIENNTRRIRLLEQMAENLYKEWFVRFRFPEHENVEIVNGLPKGWKTIHIKELAQLKSGYAFKSEWFVEEGEAVAKIKDIGNILMDTSNFSYVDKENCIKAKKFLLTTGDLTIALTGATIGKISIVPKHKGNIYTNQRLGKFFLGDNPMEKLPFLYCLFKQESMVSNIVNLSNSSSAQPNISPEQIEKIKILGNHDIISMYNKTCNPLFSNILALYSQNQLLTRQRDLLLPRLMSGKLEVKS
>CP022041.2|ASE18846.1|1316250_1317927_+|N-6-DNA-methylase
MTSTELKDLEGRLWQSADMLRAGAHLAANKYSQPILGLIFLRYADVLFKQHKEAIDTAYNEYKGTRMERSYKDIAIEKCGFFLPECAYFDYLNDAPDDAQKALLVKAAMEAIEHENPRMDGVLPKEVYGQLVPEEEPELLSRIVRVFKDIPENISIDIFGQIYEYFLGNFALAEGQGGGAFYTPASVVQYMVEVLQPATGDKKFLDPACGSGGMFVQAARYMHRHNTSNEQMMNFRCYGVEKEPDTVKLAKMNLLLNNVRGEIMEANSFYSDPYNAVGQFDYVMANPPFNVDEVVVERVTDDARFNTYGVPRNKTKSAKKASDKKETVPNANYLWIGYFATALNEQGKAALVMANSASDAGGSELEIRKKMIEDGIISQMVTLPSNMFSTVTLPATLWFFNKKRPKKDEILFIDARNIFTQVDRAHRKFSDEQVKNLGIISRLYEGDSDAFWALVEEYKAEGKQSEADWLLERWPDGKYQDIVGLCKVAKLEGEDGIIDNDYSLNAGRYVGVVIEDDGMTEEEFRTEMLSLNSEFAKLSAEAKDLESEIEKNLKELLG
>CP022041.2|ASE18845.1|1313538_1315113_+|hypothetical-protein
MKRTLFSICALVLSLTASAQIIKDTPKGKLIENLYRSSKSWVKKGWTGVQPGRYEGLVSKIVIGEDGCIYIYNPLSGLDSKSWLKLERQPDGKYRAKLPQDILTDDYGGDDDEEESSERTISLTRLVSSDDGKNYEPIGANNYVDFTVEGRTLKMSGMGQKKQIWGASFNNKWERNYGGDWALTIEPLKEQLITPPATATKSQYTVTSKSDPSPRIVEVMTNNNDIYVKGLFKAEKLANVWVKLTKQGDKAVMPTNQYLGITKKTDFKKYDSDKSEYHTFAAAFESETKAAENLEFSIDATGKLTASKILRTSLGRASNDNITGEDYIESYEGLTLTPYVQKEVGAPATPEYFYLTSTPNYDNTSNEIKLAFYVKNADINGNVLDPEKMYYNVYINGSTEPFKFKKSASQYNDMHEEEMTNIPFNYKDKRNYDFKVIDNLRILHFYDSSITRLKVVMVYESDGKKYSSEPMVASLTTDGIESANFNKTTTEKYYTVDGRQIQKLQKGLNIIKSSDGTTRKVVVK
>CP022041.2|ASE18844.1|1312540_1313494_+|hypothetical-protein
MNTKHIILMACAALLGATQANAQGQDLSILTANTDARTAAMGNASAAAEGMYLYNNPAAFFATDKKFTADASASLFEKAEGADGTFGIYALSAGYKLAKRHAVFVGFRYAGGLSLKGSDLLGNPTKDYKPYNWTLDLGYTYFLGKGFATYATGSLIYSHLSKNATGAVFSVGGAYQNNELTLANKPANLMLDAKVGAIGPQLDYGNKHKTTLPTYLAVGGALSVEVAEKHQVAAALSSRYFFQPSEAKLFMLGGGLEYTYNKMVSVRAGYEYGDHDLSHVTMGAGFKYHGLRLNGAYNLKTADTGSSYCTIGIGYDF
>CP022041.2|ASE18843.1|1309772_1312529_+|T9SS-C-terminal-target-domain-containing-protein
MRKSIIYLCACALSGMMVTTSCQDNLDSDAGVSNTRSVNIDKDLFAIKGCINVKLAKGTNQAIPTTRSGSVEMQSVPSAMTSAMQYSGAYKMERVFKPAGIYEARTVAEGLDRWYTIYFDKSKDVAAVLDQFKKAEGVECAEQVLPMARPTVKMTPYSPSGASMQATASTFDDPLLAKQWHYYNDGSVNARAKKGADCNVKPVWEKYTTGKKNVIVAVVDGGIDITHEDLKDNLYVNEKEKNGQPNVDDDGNGFVDDIYGYNFVTAKDVVGGTIEPDDGGHGTHVAGTVAARNNNGKGVAGIAGGDGSPDSGVRLLSCQIFRNKDEQGDAAAAIKYAADNGAVICQNSWGYSSTAGVTSMPQLLKEAVDYFIKMAGCDANGNQRPDSPMKGGVVMFAAGNENKEFSAYPACYAPTVSVAAMAWDFSKASYSNYAKWVTITAPGGDQDRFGTEAGVLSTVPKKKVASGYAYFQGTSMACPHVSGIAALIASYFGRQGFTNEELKSRLITAYRPYNIDEQNPTYKGKLGKGYIDAEAAFETDTKIAPEKVGTLTLKPDFVDINAEWSIAKDEDKTAAFYRLYIAQGELTADKLKDMTYREINGMGHSLGETLKYDFDDLKDNTTYSVAVVAVDRWGNLSEPMIQKCTTRLNHAPEATNFPTEAIEVMENDRKSFSFNVADPDGHNWDIKATGETKGVSYTVKGNTVTVNLVPVLEAGSYNCTFILSDDLGAKAEKSFTFKIVKYIPPQLTKPFENYIIGLDEGVVTIPLTGHYTHSGNTQLTYKATAANGSIATATISNDNLQLKGMAKGVTRISIAATDGRETSSDGSFQVRVVEKKSAPVYAVYPIPVQRDIHTLLNPEVKQAELVISSTVGERLMKATVTPDKNNVATLDLSKLNPGTYKLTVYTSKGNHTQMFIKR
>CP022041.2|ASE18842.1|1308155_1309757_+|hypothetical-protein
MRIINIHKLLQFSLLYLLLGIAVGCAENDSFDQPYLNVSEKEISFSNQIGEKTITVNTNCKEWMATTPKAWVHLSQSGNEIAVHVDPNTTGMERSSYILVDGGLAVQKIMVSQSAADITLNLNNGEVILPQAGGTTTVDLKMDATSYDLTQSEQPEWMQVIKKKHGLKFISKPNYSTTERTTKLTIAFAGKNHEVVVKQPGVATFILACNPGNPYSLHKMMDYEYRRGSFLTEYGGPDEVNGIFEESYFFKTPSPLFKDVVYVHDTKHSVPTRIYTRSLTREGVNAVKSQAFQEFMRANGYTRDEKDTNHYVNIKEAFTMDVDIREENNSVVLFFYQMHTQDRSYPTFSSLDLGPVDLLNKTDKKISDVEAYETGKNSEEMKRQMSKSNEVEAILYKTNDPTLIARTYFFYLHNDAAVPQEKAGSVEQYSLFYSQPNLGIWQYGNEWFVTHEFDKLLTANNFEFVGYNGKHHVYARRSDYLTLAISGGEYADVNNGKAVMQITVLYKPTVFAGSKEQRLAKVERMLKQYNPKK
>CP022041.2|ASE18841.1|1306499_1308119_+|hypothetical-protein
MELKKTLYSLMLGGILLCLFSCAKEDEFEMPTLVLSENSIAFDKGVSERNISVTTNQNSWIASSPQEGDWLSLVQDGNVLKVKVTENKIGTERTSYVLVNANGASGKIAVTQSAADVTLDVVPNAIYLPQTGGEKTIDITTNSSVYDVTTSEEVSWLKIVKSEEEIKLIAERNDTYQKREVKLYAKSGSVIREIVVSQSGIQRYLLPIHPGVPQDEHKIMDFELGRGSYLREYQAAMPAYGLEETYTFITASPIFTLIQYCSTDGINPSQIIMIGDGRKAIDAVKDKAFDKFLTDNGYVRSNSQSDREYTNDKDLLSLKVYISEKENNEGVNLTFTPIMKQNGEYKTFSKLPFYPLELLQKDNVKLAQIEQYEQKAGSTEEERSLNEHKNTEVSQIQYKLKASTDPSAAYGRIHIFYTTDKDGDAPDNLGSVQIGALLFKDTNLGVWKYGTKWVATKEIKKVLGDEGFSFLRTSGNNHFFVRESDHLVIDVTCVLDNAMPVLALLYSYDPSVSGASSKAIKTQAKMIRNFAAAKKALKF
>CP022041.2|ASE18840.1|1304752_1305565_+|PepSY-domain-containing-protein
MRKFCLKIHRWFALPLGVIMAILCFSGLAILLIKDLAPLFDMNAKEMPIYTIVVRLHRWLFMKPENAHEGGQSLGRILTAVSAICMSIVLLSGVVIWWPKTKKALKSRLTVSTNKGFRRFVYDSHVSLGIYVFIFLFLMALTGPVFSFGWYRAGMSKLFGQPMPPKEMKMQQPKDGMKQGGTNDKAFAPTDASQMKGQPQAHKEGAKDMKGDQHGKKPKGGKLFKQLHTGTWGGWFSRVLYAIAALIGGFLPISGYYLWWKRRSAKKKKA
>CP022041.2|ASE18839.1|1303820_1304546_+|KR-domain-containing-protein
MKKAIVVGASSGIGHEVARLLIAEGWAVGVAARRIDKLTDLQAMAPERVYTVQIDVTNEDAETSLLQLIERMNGIDLYFHAAGIGWQNPSLNADIELKTMETNAVGFTRMIGCAYRYFANKGGGHIACITSIAGTKGLGPAPAYSATKAMQNTYLQALEQLAACKHHNIHFTDIRPGFVDTPLLAGTSHLPMLMTTKKVARSIIKAINSRRHICVIDSRWCVLTYLWRHIPNWIWRRMKLC
>CP022041.2|ASE18849.1|1322765_1323911_-|DUF1735-domain-containing-protein
MNKHIFKHIAVAFAACCVVSCQDSESDLLKQKVYFDSNLYKVEMPDSGSTLGVDITSRLSNKQDGAVDVSYSLADSSLVALYNSKYGTDYVALKHQNVTFSKASSTIAAGSIYADKVSLTLNNLDQLAEGKNYMLPIKLHSSSTPVIDGEDVEYIILAKPVKITKAGDFYNKYISVKFPAGTYFKSFTYEALVHSIWWGSNCTIMGSEGLMIFRVGDVGGGISSGILQAAGRQHYEAPEKLSINKWYHVALTYDQATGKTVMYLNGTKWAESAWNISGFDPNADVGFNIGKIPGFPWGERPFYGYMSEVRVWSVARSENQIKQNMLSVDPKSDGLELYFKLNGSETVNGNKIKDSAKGIECTTGGLEFTTLAQPLTMKDLQ
>CP022041.2|ASE18850.1|1323951_1325070_-|endoglycosidase
MKNFKYISSLVLLCAGVLFCGCSKMTEVENEPYDHIGGYNTMNNAESEKYYADLRAYKQQAVNYGRPVAFGWYSNWSPAGTYRRGYLTSMPDSMDVVSMWSGAPNRFNITPEQKKDKEFVQKVKGTKLLEVTLLSYIGKGRTPDSVYTAVEKQAEKEGWANDQARVEEAKKKARWKFWGYEGVAGSDNHKEALARFAKALCDSLVANDWDGYDIDWEIGSGVFDMDGTLSTNADLVYLVKEMNKYIGPKSDPEHKGHRLICIDGHFGGLTEDLDGYVDYWIDQAYGRTTHFDYYGVDPKTIITTDNFESSFKSGGQLLRQAKSMPSKGYKGGVGAYRFDNDYDNTPNYKWMRQAIQINQQVFKERMGQTTQP
>CP022041.2|ASE18940.1|1325087_1326713_-|SusD/RagB-family-nutrient-binding-outer-membrane-lipoprotein
MKTKAYKYIVGVLALSLFTACDFQKVNTNEFELLPEEGLMDGISIGGPITAMQKCVFPVGTQADGTSVANRYQTAYNLAADCWSGYFGQNNNWGGPNNLNYFLKDGWVASSYTESYSTVVPLWQDLKGKTETQFPEVFALAQILKISAWHKATDMFGPIPYKEAGKGLITVPYDSQEEVYKAMFKELSDAIEVLTKYADNGNSKLLPNADAVYAGDVHKWVVYANSLMLRLAMRVYYADAALSKKYALQAVNHSYGVMKTKDDEAKMERGASLEFKNNLDVLINQYNECRMGSSMLAYLGGYQDPRLPKYFNTSTVSQAVTVGTYGKYSGVPTGHDVSSNDAFRDSSRPAITSTTPTYWMRASEVYFLLAEAALHGFAVGGTAESLYEKGIEMSFEENGIASSEVADYMSSGLKPSAYSFHLTNPGVNVDVPAVTEATTAWSGTDEEKLEKIMIQKWIALYPNGQEAWTEYRRTGYPKLHSVVTNYSNGEIDSEVGIRRMRFPTNKSTSAEDIANLESARKLLRGGLDKAGTRLWWDNKNH
>CP022041.2|ASE18851.1|1326719_1329830_-|SusC/RagA-family-TonB-linked-outer-membrane-protein
MRMIHETKQKHLYFSVAFALSIALAPTSVYAVGNPVGSPDASMPQAVQQNGNHKVTGRVVDSAGEPLIGATIMVEGTKEGAVTDIDGNFTINTTSKAKLVISYVGYTTQTIPVGDKTTIDVTLKEVANTMNEVVVTALGIKRAEKALSYNVQSVGSNELTRNKDANFVNSLNGKVAGVSISKSASGVGGATRVIMRGAKSIEGDNNVLYVIDGIPIFNFSGGRDSGIMGEGRVSSEGIADLNPEDIESISVLAGPSAAALYGSNAANGAILITTKKGKEGRVDISFSSSADFSSPLLMPKFQNTYGNKLGSYESWGEKLATPSSYDPKKDFFRTGTNFINALTLNMGNEFNQTFASVATTNSRGIVPNNTYDRYNFTIRNTTRMFKNRVQLDLGASYIKQKDNNMVSQGEYWNPIVAAYLFPRGESFEGIKTFERYDNVRNFPTQYWPISDSRFANQNPYWTAYRNLAPDDKDRFMFNAGLTYNIFDWLSVAGRIRLDKTFITSERKIYASSFNYFAKEKGAYDYYDYKDHQTYIDAIANINKTFGKFSLAANVGYSYSDYASLTRGYGGNLVLVPNKFSLNNINPTDSKIREAGGDSKVRNVAAFASAELGWRSMVYLTLTGRNDWNSRLVNSSEESFFYPSVGLSGIISEMTKLPSFISYLKVRGSYTEVGSPVSRSGMTPGTITTPIVGGSLKSTDIYPFTDYKAERTKSYEFGLTARFWKKLSFDFTWYKSNTYNQTFIGELPESSGYKAVYLQAGNVENRGVEMALGYSDNFGGLQWNSSLVYSKNVNEIKEMVKDYHHPLSPKPINIPEVSKDNGRVLLKVGGSINDIYARKVLAKDNQGFVNVSPSGGMNLETVEPIYLGKTTPDFTMGWNNNFTYKNFGLSFLINARVGGIVTSSTQALLDRFGVSKASADARDAGGVMIPNQGLYDAKKYYTLVATGENDLAGYYTYSATNVRLQELTLSYKFNSKLFNNVIKDLTLSFVATNPWMIYCKAPFDPELTASTGTYGQGNDYFMQPSLKSYGFSVKFKF
>CP022041.2|ASE18852.1|1330183_1331287_-|MRP-family-ATP-binding-protein
MTLYPKLITDALEKVIYPGTKKNIIESEMLADTPSINGNKVSFTLIFPRETDPFLKSTIKAAEAQIHYSVGKEVEVTITTEFKNAPRPEVGKLLPQVKNIIAVSSGKGGVGKSTVSANLAIALARLGYKVGLLDTDIFGPSMPKMFGVEDARPYGVEKDGRQLIEPVEKYGVKLLSIGFFVNPDTATLWRGSMATSALKQLIADADWGELDYFILDTPPGTSDIHLTLMQTLAITGAVIVSTPQNVALADARKGIDMYRNDKVNIPILGLVENMAWFTPAELPENKYYIFGKDGCKNLAKELGCPLLAQIPIVQSICENGDNGTPAASQVDTITGQSFLSLAQSVVTVVNRRNKEQAPTKIVDVKNG
>CP022041.2|ASE18853.1|1331417_1331795_-|hypothetical-protein
MGRNKFAEDEIKEIAKLLRLKNAGNRAKQKLVRHDLRTIYEFNISDFNEPGKAFGEEELQGAIQRGAIQILDDATIADMKAKRARDKARDEATREQQAIEAGEMTDWKAVAKEWEEWENSQNNGN
>CP022041.2|ASE18854.1|1333136_1333403_+|hypothetical-protein
MRQAISIIVLYALINILSLLFNIISFSTDGKIDIGFPFIFIHLTSAKYDPTFPYNKLLIEPFLWDIIFLFTIVCLYLCCLKFIKRIRD
>CP022041.2|ASE18855.1|1333821_1334337_+|hypothetical-protein
MILRNTKRIINYCVLMIGLGVWGSCNSKSQHVLLPVDNVKSYKICENNDTTTIFEEREEESEEVIKFYKEGSEIFTSDYGGRKELLMSTTEMLDTVYSGNTYCREHRILIKKENSNLFSTSIYNIIIHPVLVLTIYYDHSYNIKAIRNWFAFTTYESEHISIPLISRPVKY
>CP022041.2|ASE18856.1|1335329_1335629_+|hypothetical-protein
MKIKNILAVFIIVGGISYALYFSLVTDVLLKYGETIHTKAIIEERLTGKTSDPVLRYRFLYENQAYIGFVSETSRLHVSDTINIVFLKSRPSINKPLIK
>CP022041.2|ASE18857.1|1335636_1335981_+|hypothetical-protein
MKKNLLFSFDDEITTGVYYDIDGHKIVVYFAAYYDNGRFVEKKCQLIIEKWEYAKSKLSVDNRYKDLEDHIGIISMILDMHIADKKLFLTVNTLDGQYVDLLFYNCNVKIEDIS

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP022041_3	3.1|351643|57|CP022041|CRISPRCasFinder	351643-351699	57	CP022041.2	490724-490780	0	1.0
CP022041_3	3.1|351643|57|CP022041|CRISPRCasFinder	351643-351699	57	CP022041.2	490808-490864	0	1.0
CP022041_5	5.2|479165|28|CP022041|PILER-CR	479165-479192	28	CP022041.2	476356-476383	2	0.929

1. spacer 3.1|351643|57|CP022041|CRISPRCasFinder matches to position: 490724-490780, mismatch: 0, identity: 1.0

acttattgctatataattcgtgtcattcgcgtaattcgcagtcaactttttgattag	CRISPR spacer
acttattgctatataattcgtgtcattcgcgtaattcgcagtcaactttttgattag	Protospacer
*********************************************************

2. spacer 3.1|351643|57|CP022041|CRISPRCasFinder matches to position: 490808-490864, mismatch: 0, identity: 1.0

acttattgctatataattcgtgtcattcgcgtaattcgcagtcaactttttgattag	CRISPR spacer
acttattgctatataattcgtgtcattcgcgtaattcgcagtcaactttttgattag	Protospacer
*********************************************************

3. spacer 5.2|479165|28|CP022041|PILER-CR matches to position: 476356-476383, mismatch: 2, identity: 0.929

agcaacttgttaacttgtctactcgttg	CRISPR spacer
agcaacttgttcacttgtccactcgttg	Protospacer
*********** *******.********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP022041_5	5.2|479165|28|CP022041|PILER-CR	479165-479192	28	MK552327	Pseudomonas phage Psa21, complete genome	200921-200948	7	0.75
CP022041_8	8.1|515392|29|CP022041|CRISPRCasFinder	515392-515420	29	NZ_CP020004	Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed2, complete sequence	38937-38965	7	0.759
CP022041_8	8.1|515392|29|CP022041|CRISPRCasFinder	515392-515420	29	NC_048762	Bacillus phage vB_BtS_B83, complete genome	5072-5100	7	0.759
CP022041_8	8.1|515392|29|CP022041|CRISPRCasFinder	515392-515420	29	KY290956	Aeromonas phage L9-6, complete genome	93770-93798	8	0.724
CP022041_8	8.1|515392|29|CP022041|CRISPRCasFinder	515392-515420	29	KY290951	Aeromonas phage 31.2, complete genome	93171-93199	8	0.724
CP022041_8	8.1|515392|29|CP022041|CRISPRCasFinder	515392-515420	29	NC_005135	Aeromonas phage 44RR2.8t, complete genome	93412-93440	8	0.724
CP022041_8	8.1|515392|29|CP022041|CRISPRCasFinder	515392-515420	29	AY962392	Aeromonas phage 31, complete genome	93174-93202	8	0.724
CP022041_8	8.1|515392|29|CP022041|CRISPRCasFinder	515392-515420	29	KY290958	Aeromonas phage SW69-9, complete genome	93306-93334	8	0.724
CP022041_8	8.1|515392|29|CP022041|CRISPRCasFinder	515392-515420	29	AY375531	Bacteriophage 44RR2.8t, complete genome	93412-93440	8	0.724
CP022041_8	8.1|515392|29|CP022041|CRISPRCasFinder	515392-515420	29	KY290948	Aeromonas phage 44RR2.8t.2, complete genome	93412-93440	8	0.724
CP022041_8	8.1|515392|29|CP022041|CRISPRCasFinder	515392-515420	29	KY290957	Aeromonas phage Riv-10, complete genome	94507-94535	8	0.724

1. spacer 5.2|479165|28|CP022041|PILER-CR matches to MK552327 (Pseudomonas phage Psa21, complete genome) position: , mismatch: 7, identity: 0.75

agcaacttgttaacttgtctactcgttg	CRISPR spacer
gtcaacttgctaacttgtctactactga	Protospacer
. *******.*************  * .

2. spacer 8.1|515392|29|CP022041|CRISPRCasFinder matches to NZ_CP020004 (Bacillus thuringiensis strain Bacillus thuringiensis L-7601 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.759

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaggaacaagtgtttatgcctc	Protospacer
********* *****.*******     *

3. spacer 8.1|515392|29|CP022041|CRISPRCasFinder matches to NC_048762 (Bacillus phage vB_BtS_B83, complete genome) position: , mismatch: 7, identity: 0.759

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaggaacaagtgtttatgcctc	Protospacer
********* *****.*******     *

4. spacer 8.1|515392|29|CP022041|CRISPRCasFinder matches to KY290956 (Aeromonas phage L9-6, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *  

5. spacer 8.1|515392|29|CP022041|CRISPRCasFinder matches to KY290951 (Aeromonas phage 31.2, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *  

6. spacer 8.1|515392|29|CP022041|CRISPRCasFinder matches to NC_005135 (Aeromonas phage 44RR2.8t, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *  

7. spacer 8.1|515392|29|CP022041|CRISPRCasFinder matches to AY962392 (Aeromonas phage 31, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *  

8. spacer 8.1|515392|29|CP022041|CRISPRCasFinder matches to KY290958 (Aeromonas phage SW69-9, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *  

9. spacer 8.1|515392|29|CP022041|CRISPRCasFinder matches to AY375531 (Bacteriophage 44RR2.8t, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *  

10. spacer 8.1|515392|29|CP022041|CRISPRCasFinder matches to KY290948 (Aeromonas phage 44RR2.8t.2, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *  

11. spacer 8.1|515392|29|CP022041|CRISPRCasFinder matches to KY290957 (Aeromonas phage Riv-10, complete genome) position: , mismatch: 8, identity: 0.724

agtaacagatgaacaggtgtttagtggac	CRISPR spacer
agtaacagaagaacaggtgttcgactgca	Protospacer
********* ***********.... *  

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	220916 : 251291	29	unidentified_phage(33.33%)	transposase,integrase,protease	attL 246311:246325|attR 256553:256567
DBSCAN-SWA_2	918244 : 925858	6	Prochlorococcus_phage(33.33%)	NA	NA
DBSCAN-SWA_3	1279773 : 1354453	52	Staphylococcus_phage(22.22%)	transposase,integrase	attL 1337644:1337658|attR 1366005:1366019

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>CP022041|220916:251291|DBSCAN-SWA
CATGAAGAATCACCAATTATTACGTTGCATCTTTCCAGATGTACTTGCTGACTACTTTGATGTTGTCGATATTCAAGAGAGTGTTTCGCAGATTGACTTTTGGCTTGACGAGCGTAACTTTATGGAAAAGTCAGATCATAAGTTAGGCACTGTAAGCAGTTATGGTTTTACCAGCGAGCGTGTTATTCAGGACTTCCCCCTTCGTGGCAAAGCAGTTTACCGCCATGTTCGTCGTCGCAAGTGGCGTGACAGTTCCAACGGAGAGATATTTACTTATTCATATGATGATTTGACGGCTGAGGGTAGTAGACTATCTCCCGAGTTCGTTTCTTTTTTAAAAGAATAGAATTGAGTCCACTGCAGAGAGCATCGCAAGCATTGGTTCGCACTATGGCGTAAATGGCAAGCTGTTATCCACACAGTACAAGGAACATTTCAGTGATTACCGTAGCTGGGATCAGTTGGATCATGCTCAAGACTGGCTATTGTTTGAAGATAACATAGGAGAGAGTCTAAGTATTGATGAGACCTGTCTAAGCTGTGGCGAGGTTTATACTTTTCTGACCAACAAGGCAGGAAAGGGCAGAGAAGGGACTTTGGTAGCTGTGGTTAAAGGGACCAAGGCAGAGGACGTCATCCAGATTCTCAAGAAGATAAACCTTTCTAAACGAAAGACTGTCAAGGAGATAACACTCGACTTATCATCTTCTATGATGCGCATAGCCCGTGCTGTTTTTCCCAAAGCACTTATTACCAATGATAGATTTCATGTGCAGAAACTATATTATGATGCTCTGGATGACATGCGTATCGCTTACCGATGGATGGCAAGAGATAAAGAGAATGAGGAGATAAAAGAAGCTAAATGTAAGGGTAAGGAATATATACCATTTAGATACAGCAATGGTGACACGCGTAAGCAGTTGCTTGCCAGAGCAAAGTTCATATTGACCAAGCACAAGACCAAGTGGACTGAAACACAGAAAGGTAGGGCAGAAATCATCTTTGAACATTATCCGACACTGAAAAAGGCATATGATTTGGCTATGAAACTTACCGATATTTATAACATCAAGAGCATCAAGGATGCTGCAAGGCTGAAGTTGGCAAAATGGTTTAATGAAGTTGAAGAGTTGGGAGTGGACAATTTCTACACAGTGATTGACACGTTTGAAAATCATTATCAAACCATACTCAATTTCTTTGTAAACAGAGCTACGAATGCAAATGCCGAGTCATTCAATGCTAAGGTTAAGGCATTCAGGGCGCAGTTCAGAGGAGTCACAGATATTCCTTTCTTTTTATATAGGCTTATGAAATTGTGTGCTTAAGAGTATAGGCTTGCAACTGGGTTTTAGGACTGACCCATAAAAAGTTCAAAGTATTCAACGCTCCTTGGTGGTGTGTGAGATTTAAATAACGCACATTCAATTAGTAAACACGAATGCTCTCGGTTAGAAATATATTTACAAAACACATATGAAAAGGGCTGGGGACTGAGCTGAAAACAAGAAAATTTACCACATTTGTAAGTCTTTTGTAATCAATTAGTTGCGGAAGTGTCTTCCAAAAGGTACCTAATAAGACTTCAAAAGGGCGTTAGTAAGGGGCTTAAAGGGCATCTTTTGCAAGCTAAAAGGGCGTTAATTGGAAGCCAATTAAGCCTTAATAAAAATCGAAGGAGGGAAAAATATTGACAAAACGAGGAGTAAACGGGTGGGGGAATACTCACCTTAAAGCCCTCTATCAATCCATAGGGACAGTTTTTCATTACCTCATGTTTTATCTTGTGTGTTCAGTCTTCAACTCTCCAATATTAGAAGCAATGGCGTTTAAGGAACTCCTCATACTGGTTGCGATAGCCATTGAAAACATTGATATCAACATCGCCATGGATGCCACGCACCTTACCATCAGGACTTAACTGCCAGTAAGCTAACTTGAAGTTGGGCTTATATTCGCCATAACGGGCTATCCATATGTGATAGTTATCGCCCAAATCGGGTGCCAATGGCATGTAACGGTTAGCAAACGACTGACTGATATAGAGTATCGGGCGATGACCCGTATGTTTAAATACCATAGACATCCATATCCTCACTTGTTTGAACAGCACTTCAGCACCTCCCATAGCATGAATTTGCGCATCAGTAGGCTCTACGTCGAGCACGGGGGGTAGGTCGCCTTTCCGGAATCGAGCTTTCTTTAAGAAGAAGTTAGCCTGCATATAGCCCGAAGACAAGGTTGAGAAGAAATGATAAGAGCCCACTCTAATCCCCTGCTGACGGGCTGCCAAGTAATCAGAATAGTAATAGCTGTTGAGTAAAGTTCGCCCTTCAGTTGCCTTAACATAGGCGAATGAGACTGGATAGTCAACTATGCCTTTCACCTTCTTATTGCTTAATGTACCAAGATGAGTGATTCTTAACTTGCTCCAAGCTATGCTGTAACGCTGCTCCCCCTTCTCATGTTGATGTTTAGAAAGGTCTATGCCATAGATACGATCAGCGTTGTAAGTGAGGCGTTCGCCCTTAAATACGTTGTTCTTCCACTCCCCTACCTTCAGAAAGTCATGTGGCGCAACATTGATACCAAAGCCATTTCGCTTGCCATCCTGCCAATGCCCATCATAAAAACTACCATCATTACCATAATACTGACCATATCCCTCAGCCTTTCCTCCTCGTTGCTCGCCAACGTAATAACCCGCAGAATCAATCAAAGCTCCTGCTGGAAAGCCAAGAACAGGATGCGAGTAAGCCTTGAAGTGACGCAAACTCTCTTGCATTCCTCGCTCTCTGCCGAAGCGTGAAGAGATCCTCCAAGGAGTCATACAATCAGATGTCTGCAAGCAAAGAGCCCATCGGTTTGATTCATCATTCAAGCGATTACAAACCATTATCTCGCCGGGCTTATACCATACACGTGCTGTGTATTGACTCAATTGACGGATTCGAAGACGTGCAGTAGGTTTTATATCTTGCAAAACGTGTATAATCCTTTGCAATGAATCTATCTGATGAACCACCGCTGTATGATAATCGGCAATCTTGTTATAACCATAGTCTTGCACACTATGAACACGCAAATAATAGGCAGTTTCATTGCGCTTGGACTGTAAACCCACTAACTTTATATCCATCTTCATCAATGCGTACATCAATACCTGACGCAACTTCTGATCCTTCAGATTGATAATTGTGGAAGGATAATGACGCCTTATCACAGCTATACGCCCAAAGCAAGAAGGCAAAATGGGGAGTTTATTCACCCAATAGCCCTCTGTTACGGACATACGTGAGCGTATAGAGTCACCTGGCAGACTACCATCTACAAAGGTGGAGTCGGTATAATTGGAGAAATAAGCTGCTGGTTTACCATCAACGTCCAACTGATAATAAGACTTTTCAGTAACATCTACGGCACATCTTTGTATATGTCTTCTTGTCAACGAGAGGTTACGCCTGGCAATAGATGACAATAAGAGGGCTACGAGAATAATACTTACACTCTCGTAAAAACTCCTGTTAAAGAACGAACGAAACATCTAAATAACCTTTAAAATATTTGCAAAGTTACAAATAATTATCTAACTTTGCGGCCAAGTTTATGAGAAAAACGACAGACATATTACTATCCCTTCTATTGTCAACGATGATAGTATGGATTGGTTCGGGCATCATGACAGTGGTGTGCGCACATACTGGCAATGTGTCTGTTGCTAAGATGGAGGATAAAGGTCATTGCAATGATAACGGTGTAAAAAATTGCATGAAGATTGAGGTAAAAAGCTTGTCGCCCACAGACATGGCGCACAATGACTTTTACCAGATTCAACCAATACAGCTTTCTCTTCTCCCACAATTCGTAAGTGATTGTCAATTATTGCCTTTGCCTGTTTTGACAAAGGCCCCAGAGAGGATATTGTCGTTGCTCTGGCATAGTCCGCCACGCCAATATCTCCGATTACTTACGACACTTATCATTTGATTTTTGGTTGTTTTCTGTTCCTCATGAAATGGGCAACAGAAGGTTTATCGTACCTGTTACACAAGTGTGTTCGGGTAAAAAAGCGTATCAGTATGTTTCCCATTCTGATACCAACACAGGCTTTATAAATTTTAAATAACAACTGGATATCAAACGAAATGAATAAAATTATATATTTAGCAGGACTGACCTTGCTGTCTGTCCTACCTGCTACCGCACAGGAAGCTGCTGTCGACACGACCGCAACCATGAAAGATCAGACATTGGATAACGTGACCGTTACAACGCGAAGAGCCTCTGTGCACTCATTAGCTGGAGCCATCAACGGTAAAGACATCCTACGTGACGAACTCTTCAAGGCAGCTTGCTGTAACCTTGGTGAGAGCTTTGTCAACAATGCTTCAGTAGATGTAAACTACTCGGATGCGACAACAGGAGCCAAACAAATCAAACTCCTTGGTCTTAGTGGTACGTATGTTCAGATGCTGACCGAGAACCTTCCAAACTTTCGTGGTGCTGCCCTCCCTTACGGTTTGGGCTATGTTCCAGGCAGTTGGATGAAGAGTATGCAGGTGAGTAAGGGTAATACATCTGTCAAGAATGGCTACGAAGCGATGACAGGTCAGATTAATGTAGAATACGTTAAACCTGAAGATCCAACAGGTATGAGCGTCAACCTCTATGGCAATACGGTGGGAAGATTCGAGGCAAATGCGGATGGTAACATTCATATCAATGGTAACAAGAACCTCAGTACGGAAATCCTTGCCCACTATGAGAACAACTGGCTACATCATGATGGCAACGGAGACGGATTCCAAGATGCCCCAAAGGTGAGACAATATAACCTGCAGAACCGTTGGTTTTGGAAGAAGGGCGATTATATCTTACATGCTGGTTTGTCGCTGTTGAAGGAAGATCGCGTGAGTGGTCAGACTCCTCATGCTGCTGCAACGAATCCTTATCGCATTGATATCGGCACCGACCGCTACGAGGCTTATATGAAACATGCCTTTGTTCTCAATAAGGAACACGCCACAAACATCGCTTTGATGGGTAATGTTTCTATGCACAAGCAGCAGGCGCAATATGGTATTAAGCAGTATGATGTCAACGAAAAGAATGCTTATGCATCACTTATGTTTGAGACAAACTTCACCGATGAGCACAATCTCTCTGCTGGTTTGAGTCTCAACCATGATTACTTGCATCAGACGCTGACACTCCCAGCAACGGCTGTACCTTCTGATTACGGTAATATCTACCCGCTCACACGTGGTATTGAGAGCGAAACAACACCGGGCGCATACGTTCAGTACACCTATAACTTGCATAGTCGCTTCATCGCTATGGCAGGATTGCGCGTCGACCATAGCAATGTTTACGGTACGTTCTTCACTCCTCGCTTCCACTTGAAATGGGTGCCAGCTGACTTCCTGACCCTTCGCCTCTCTGCAGGTAAGGGCTATCGCAGTCCGCACGCTTTGGCAGAGAACAATTACCTCATGGCTTCGGGTCGCCGACTCATCATCGATAAGCTTGATCAAGAGGCTGCATGGAACTATGGTGCGAGTCTTAATTTCAACATTCCAATAGGAAATAAGATGCTGAAAATCAATACTGATTACTATTACACGCACTTCCTTTCACAGATGTTGATTGACTATGACAGTAATCCACAGGAGCTACATATCACCAATCTCAATGGAAAGAGCTTCTCGCACACCTTCCAAATCGATGCTTCCTACCCTCTTTTCAAGGGCTTTGAACTGACGGCAGCCTACCGATACAACCTCGTGAAGGCGACGTATGGAGGAAAACTGATGTGGAAACCACTACAGAGTCGTTACAAAGGACTCTTAACGCTCAGCTATAAAACACCTTTAGGAGTTTGGCAGTTTGATGCTACTGCAGCCTTGAACGGAGGTGGTAGAATGCCAGAATCTTACACCTTAGCATCGGGCGAACGCTCATGGGCGGGCAGCTATAAAGCCTATGGACAGCTTAGCGGGCAGGTGACACGCTACTTCCGCCACTTCTCGCTTTACATAGGTGGGGAAAACCTTACCAATTATAAGCAGAAGAACCCAATCATTGGTTATCAAAATCCATGGGCTAACAGCTTCGAACCAACAATGGTCTATGGTCCTGTAGAGGGTGCAATGGCATATGTTGGTATCCGTCTGAACCTCGGTAAACGACAGTAAACATACATTTTTCACAATAGAATAACATAAACGACAACACAGAGAGACGTCTTGAAACACGCTTTCGGACGTCTCCCTCAAACAAAGAACAATTATGAAAAAAGCTATTTTCACAATGCTGATGCTCATGGTAGCCATGATTGCAACAGCCAAAGACATTAAGACAGTTATCTTCACAACTACTCCACAGATGCACTGTGCTAACTGTGAGGCGAAAGTAAAGAACAATCTCCGCTTTGCAAAGGGTGTGAAGGAGATTAAGACAAGTGTAGAAGAACAGAAAGTTTATGTAACCTACGATGCCCAGAAGACCAATGAGGAGAAGCTTCAGAAGGCTTTTGAGAAGTTCGGTTATAAGGCAGAAAAGACGACAAAGGAGGCTAAAATCCCTGTTCATGAGAACGAGGAGTGCGAGAATATGTAAGGGGCTGAACATGCAAATACTAAATTGTGATTCTCTGAACCCTATTATATAAATAGGAGAAAGGGGCAAACTTCAGCTGAGTAGTCTATCGCTACAGCATTCGAAGTTTGCCCCTTCGCTATTAATTTCTATCTGAAGAAATAATGACTGCTTCGTACTTTTGTAATAATAAAATCACAACTGTTTTTTATTCTACCCTCTTTTGCCTCTGAATTAACGCCCAATTAACGTGCAAAAGATGCCCTTTAAGCCTCTCACTAACGCCCTTTTGAACCCTTACTAAGCACCTTTTCAAATCGACCTTCACAACTACCTGACAGCAAACTACTTACAACAACACTTAAAACGTATATATTTTGCCCTTTTTCTCGCCTTATCGCCGAGAAGATTGTAATAATATTTCAAAGCTCAAAGTTCGATTTTTCAAACTTAAAGTTGCTGCACATTCTCTCATAGAGTTCACTGATAAACAGAAAAAAACAGCCCCGATTTGCTTGTATTGGAGACAAGGTAACATAAGAATGTGGTTTAGAGTAGAGCACAAGTTCCCAAGTTACTTGAAGCAATAAACCACACACCACGATAGTAATCATGATTCTGACCTACTGATGAGAACTCTGTTCGAATAATTATGAATTACAGATAATAACCTTCCCTTGTGAGCGATGATTAGCAACATCGCTCAGAGCCTCTTCTGCTTGTTCTAACGTATAGACATTACCTATCTCTGGGCGTATCTGACGAGCTTCAAGAATAGCTGTTGCGTTGCGTAACTGTGCGCCATCAGCGGTCACGAAGATGAAATGATAATGCTGATTTCGTTTGCTTGCCAACTTCTCATTCTTCATACCAACCAACTTAAACAGCCATTGCTTCCAGAGCGGCAAACCGAACGACTTAGCGAAACTGCCATTAGGCATACCTTTCAAAGAGACAAGCGTTGCACCTTCTCGAAGAACTGAGAAAAGTCTCGGTAGCTCTTTATCACCAAGCGAATCGATTGCACCATCAATATCCTTCAACTCTTTGGTGTAATCTTCTGTTTTGTAATCAAAATATTGGCTCACACCAAGTTCCATCGTGCGCTCTTTGGCTTTTGCACCACCACTGGTAATAACCTTCAATCCACGTGCTGCTGCCAAAGGGATAGCCATAGCACCGAAGCTACCAGAGCCACCAGAAATAAACAAACTATTCCCTGACTTTAACTTGAGAATGTCAAGCGCCTGCTCAGCTGTCAGTGCGGTCAATGGTACAGCAGCAGCCTCTATATCTGAAAGGTAATCTGGTGTTTTGGCAACTGCCGCAGCATCTACTGCAACATACTCAGCAAAGGCACCGATACGATTGATAGGAAGTCTACCGAACACACGATCGCCAACCTGAAAGTCCTTTACCGACGCTCCAACCTGCTCTACCACACCAGACATCTCATTTCCAATGGTCAATGGGAAGTGGTAAGGTACAACCATCTTCACATCTCCATGTGCAATGAGCAACTCTAATGGGTTGACAGCAGCAGCCTTTACCTTTACTAACAAGTCGTTATCGCCCACCTTTGGCATTTCTATATCACGTAAGGCAACCTTAACATCACCTTTCTTATATCCGTCTATCTGTATTGCTTTCATATCTTTATACTATTTAAAAAACTCTATTGCTTCTGGAACAAACACCTCATGGTATTGGAAAACACCTCCATGACCTGCATCTGGATAAATCGTCAGATGAGCATTGGGCAGTCTTTCTGCTAAGTCATACGAATTAGGCGTAGGGACCATTCTGTCATTATCACCATTGACAACCCATACAGGAATCTTGATTTTCGACAAATCGTCTTTCTCTCGGCTGCCCCATACGTCAATGGCTCTTAGCTGTCTTTGGAAAGAAGAAAGCTTTATCTTGTCATCTTTGTCCTCTGTACGTGCAATGCGCTTCAGAAAGTTATTCGCTGCTTTCTTGCCTTGCTCAATCATAGGGAAGAAGAGATAATACTTAGGGTCACGACCAGTGAGGAAAGCCCTGAACATATCCCAATACGTAATCTTCGCTACATTCTTTATGCCTACACCACCAGCGCCGCCTGTTCCTGCAAGAATAGCCTTCGTGGTTAAGGCTGGCGCACGAAGCAAAACCTGCTGTGCAACAAACCCACCCAATGAAAATCCAAGAAGACGAATGTCTTTAAGACCATAAGCCTCAGCAAAATCAATCACGTCGTCTGCCATTTCCTCAATCGTAAGACGTGACTTGCCAGTAGACTTACCAACGCCGACATAATCAATTCCAATGACATTGAAATGTTCTGCCAACCCATCCATTATTGCTGGGTCGAAATTATCTAATGTTGCTGCAAGGTGATTGAGACAAAGAAGTGGAGGATTTTTCACATCACCTAACTGTCTGTAGGCTACTTGCTCTGTCTTTACTTTTAATATTTGAGTCGTAGTGTTTGAATAACTTGTATTTACCATACCTATTTAATCTTTTACCATTTTATCCATATTCTTAGTTCCCCAGTCAAATAAAGCATCAAGCGGACCAAGAAACGAACGTCCTAATTCGGTTAGACCATACTCTACTCTCGGTGGAACTTCTGGATACACCTTGCGGTTTACCAGTTTGTTCTTCTCCAGATTCTTCAATGTTTGAGAGAGCATCTTCTGTGAACAGTCGAGCATATACGAATGAATCTCTGAATAACGCATCTTTTCCTTACCCGCTTTACCGAGTATATAGAGGGCTAACATTGACCATTTATCACCAATGCGAGTAATCACTTGACGAATTGGACAAGCCGAATATCGTGAATCAATCTCTTTACTAATCGTCTTCATACCTGTAAAGTTACACATTTCCAACGAATAGTTGCATACTTACCATTAGAAAGTTACTTAAAAACATTTAACCCTTATCGCTCATTAGAGCCTAAACAGATTTTTGTTTTATTATCGAACAGATTGACTGCCTTTGTAACGCAAGCGTAGCGGGCTACGTTAACTTACAAAGAAAGAAAAGATGACAACAAGAAAATAAAAGATGTTAGGAAGCAACATATAAATAAGAATTATGTTGTTTCCTAACAGATTATGTGTGTTAATTATTTCCTTTCTCTATTCTTACCCACAACTGGAACAGTGCTGGAACAAAGATACAGAGTGAGAAGAACAGACCTCCGTACATCATGCGGTCGTTGCCATGGAAGAAGTCGATGAGTTTTCCATCGTTCATCTGTGGCATGAGGTTGAACATTAGATAAGCCACCGTATTGTTCACCCAATGAAATACGAAACCTGGCAGAATACTCCCCGTTTTTGAATAGAGCCAACCCAATAGCAAACCAATCAAGAAAGCGTGTAAGCCCTGTGCTAAATTGAAATGAATAATACCGAAGATGAGGGCTGAAACGACAATGGCTATCCATCGTTTGCGTTCGCCTAACACGTTTTGCAGTACGCGCTGAATTGCACCTCGGAAGACTATCTCTTCGGCTATTGGCACCATTAAGCCCAAGGCAACATAGCCCCAAGACACCTTCATGATACTTTCAAACATCTCTTCTGTGCCCGCTGGCATCGTTAGATTAATCTTCTCGGCAAGGAATTGCAGCGGGAGTATCGAACCTAAAGCTATGAGAGCCGACCACATGAGGACAGCCCAAGGACGCGTCTTCAAATAGTTACCTGATACAGGTGCCCACTTTGTAGCGATGAAAAGAATTAAAGTTGCAAGACTACTGATGACTGCCGTTATGGCAAGAGTCTCACCATTTTTAGTCAGATAATCCCCATCAGCAGCCTCTGTCCCTCCAAGTAGGCTTACAAGCTCCTTACCTCCTTTGAAAGAAAGACTTTGTATCAAGATGAAAAGTGAAACAAATAAGATGACATAGAGCGTTGCGCTCAAAACGTTTTTATTGTTCATTTCTGCGAATCTTAGGGTGTATTAATAATATTCTCTTGTATGTGATAAGTCTCATCAAACAATCGATTGATTTGCTCTTTGTCTTGCTTCAGCTGTTGTGCCAAGGCTTCTAAAGAGTCAAACTTATGCTCGTCTCTTATCTTACTAATGAAACTTACAAGGAGTTCCTGTCCATAGAGATTTCCTGTGAAATTAAAGAGATTGACCTCTATCGAGGTGGTTGTGCCATTGAAAGTAGGCCGATGCCCAATGTTCATCATCCCTCGCTTCCATTCGACAGAATCCTTCAAGCGCACCATGACCGCATAGACACCACTTGCAGGGAGCAGCTGTTGGCAACCATTCACATCGAGATTGGCTGTAGGGAAACCCATCTTGCGCCCATTCTGATAGCCACTCACGATGCGACTCTCTATCGTATAAGGATAGCCTAAAAGGCGGTTGGCTGCCTCAATATTACCCGCGCGGAGGTCGTTTCTGATGACAGAAGAACTCACTTTCTCATCATTTGGCAGGAAGGCATCTGCACGAATGACCTCAATACCCATCTCCTTACCATACTGAACATAGTCTTCAAAAGTTTCAGAGCGGTTATGTCCGAATCGGTTGTCGTAGCCAATGATGAGTTTCTTTACATTCAGCTGTTTGCACAACACCTCTTGCATGAAGTCATGAGCTGAGAGCGCAGCCAACGAAGCATCGAAATGCAGTACGAAACTATTGTCAATATGTGTCTTTGAGAGCAGTAATAGCTTCTCATCGAGTGTTGACAGCAGTTCTGGTTGGTAGTCAGCCTGCAGCACCTGACGCGGATGTCGGTCGAAGGTGATGACTGCCGATGCCATTCCAGACCGTTCAGCCTCGTCAATGACACGACTAATCAGGAACTGATGTCCACGATGCACCCCATCAAAGAACCCTATGGTTGCAACCTGTTCTACTAATTCATGCGCCTCATCTCGCTTAATATATATTGTATTCAATCCTCTTGTCTTATAGTTCGTTTACTTCCTTGTAAAGGTATTTTTATTTCCCTGCAAGCGGTGTTAAGCTCTCTGCAAAGATAGTCTCACCTTGTTACGAAGCCATTTTTACTTTCTTGCAAAGGTACTCCAAATCACCCATAAACCCATGTTTGGGTAAACAAAATGTGTTAAAACATTAAATTTCCTTATCGTCCTTTCTCCTTTTTCCATTTATTTCATTATCTTTGCAGCCGAATTCACGAAATTCAGGACTTGTAGCTCAGTTGGTTAGAGCAACAGACTCATAATCTGGAGGTCCCTGGTTCAAGCCCAGGCTGGTCCACAAAGGGAAAAGAAGAGCTTTACACTATGCTGTAAGGCTCTTTTTTGTTGGTAATCAAGTAGTTTCATCAGTAGGTTATGATGGCTATAACGGTTCATTTGTTGTAAAATCCCTCTATCTTCTCCTTAGTTTAGAACGTACATATCACGCTATTTTGAGCAAAATTTCAGCTAATTTATCCACTTGTTGACCTCCTGTTGACCCGAGGTTGACCCGAGGTTGACCTCAAAACGAGAGATTATGCTGACAATTAAAGCAGAAATTCAGAGAGACAAGTTAAGGCAAGATGGTAGTTACAATGTCCGCATCAGATTTACGAAAGATCGTAAGGTAAAACGTATTTCCACAAGTCTGTTTGCAACAAAAGCCGATTTAACTGACAGGTTTACTATCAAGGAAGATTCTCTTATCAAACAGGAAGCGGACATACTTATCCTGCATTACCGTAAGATGTTTAACGAAATGCACTTGGAGACAGAGGCGCTTGATGTAAACGAGATTGTAGCCCGACTGACCAGCAGGGAGGAAAGCGATAAGCCTGTAGATTTTATCCAGTTCGCTAAGGGATGGATTGCCAATTCCACGTTAAAGGGAGCAGTCAACTACACCTCCGCACTTAACAGCCTCATCCGTTTCAACAAAAGTGATAAGCTGTACACACATCAAATTACAAGTGAATTCCTGCAAGAGTTTATGGCATTCTTACTCAATGAAAGCAAAGAACGAGCGGAACAATTGAAGAAGAAAGGCAAGCGTGTTCCCTCCACTCGCAGTACCTCCCTTTACTTAATGAGCATTCGTAGATTGTTTAAGGAGGCTGTAAAGCAATACAACAAGCCAGACCAAGGGCTAATCCGTATCAGGAACACCCCATTTGTTTATTTCCAAATCCCCAAACAGGAAGCAACACGAAAAAGAGCTATCACAGCAGAATTAATCCGTAAGATAGAGCAGTTACCGTATCAGACAGTTTATAAAGGCATACATCACACCAACCGCTTCAATCTCGCAAAGGATTGTTTTATCCTCTCATTTTGCATGATAGGAATAAATTCTGTGGATTTATTTAACGCAACCGAATATGATGGCAATACGATTACTTACTATCGTACTAAGACGAGAGACAGGAGAATGGATAAAGCTAAGATGATAGTAACAGTTCCTAAGATGTTGCATCCTTTGTTTGAGAAGTACAAGGATACAACAGGCAAACGGATATTCAATTTCTACCAGAATTATGTCAATGAGAAAGCCTTTAACAAAGCCATCAACAAGGGATTGAAAGAGATTGGTAGTATTCTTAAAATTGAGGATTTAGAATATTATGCTGCACGCCATTCTTGGGCTACCATTGCCCTTAACAAGGTCGGAGTAAGCAAATACGTGGTACACGAAGCCCTCAATCATATTGACGAATCTATGCGAGTAACCGACATTTATATTGAACGTGACTTCTCGAATGAGAATAAGGCAAATGCAAAAGTCGTAAAATATGTGTTTGGGAAATAATGTGACAGAATATAACGAAAAAAAGTTTTATACCCCTTGTTTAGAAAATGTCACCCAAAGAAAACTCCATCGGCTCTAATGCAGGTGGAGTCTTTTTATTACCTTTGCAGGGTATCAAAAGATAAAGGATATGACATTTGAGATTAATAAAACAGAATATATTGCTGTTATAGCTGGAATGGACTGTTTACCACGTATCAATGAGGACGAAATTATAGATCCCTCATATATCGAACTGGCTCAAAAGGCAGCGACAGATCATTTTGCTAATAGATTTTCCAAGTTATTCAAGGATAATCAAGAAAAGTACGAATTATTCCTTGGAAATAATCATATTCAAAAGCAACTATCGAAATGGCAACTTGACCCTATCAAATTCTGGTATCTACATTTGTTTATCATCGATTATGCAACAGATGCCTTTAGAAGTGTCACCATATTTGAGGAACTAAGCACAAAGCAGTATATTGAAAAACTTATCAAATCCTTAGAAAAAACAGATATAGAGAATTTCTGTCTCGATATAAGGATTAATAAAGAGAAGTTGTCAACTCGAAATCCTTGGGTAGGTGAAGCCTTACTTTCTGCTCTAAAACAAGATTTCCCATTTGACTGGGTAAATAATAATACGTTTGTTTCTAAAGATATCAAAGAGGATATAGAACGCTACACAACTGCAAGAATGAAATTTTCCACAGAATTATACAGCCACTTCTTTGATCAATATCTTCACAAATCACAACGAGGTAGAAAGTCCTTTATAGGTAAATTCCTTTACTTGGCTGATTTGACAAGGGATGAACGTTATTGGTATGGATGTAAACCAACATTAGAGAAAGTCTGTAAGAAATACGAAATTGCCCAATATCAAAAGATTATGGTTGAGGGAGTAGAACATATTGCCATACCATTTGATGTGGGAAAGGATTTATCAGACCACATAAAGAAATGTACCATGATTCCCCAAGTACGCCATTCTTTCTACTTTTCTCCAGTTGACGAGTAAGTAACTATCATCCATTATTTTAGGTTTTAGGGAATTTTCCATTGTAAAAAGTTCCCTAAAACCCTCAAGCCTTTTTTACTTTCTTTCTCCTTAATTTCCCCTTACCTTTGCATCGCAATCACGAGACAAGCGCGCTGTCTAAGTGATTGTGAGGTAACAGGTTCACCTCTGATGTAAGAACCTTAAAGACAAAGAAGATGAATAACAAAACTTTAGACCTAAGAATAGATAACGCAGAGACATCTGCAAGTACAGGAACTCAAAACAACAAAAGCATGAATAAAGGAACATTCACATTACCGACTTTACAGAAAGCACAAAACCAGTATGACAACATTGGAGCTTACAACCAACTGCAAGCAATGATGAAAGCAGGACAGAAATTATCTGTCAAGTTCTATACAGGGAAGGGCAACAAGCCATGTGCTTGGATTGAGAGTAAGCAAGTGACAGGATTTAGGTACGAAGTCAAAGACACAAGTTTTAAAGGTTTGATGAACTACCTCATATCAGGTGAGGTTGCTGATTTTGACACTTCACCTATGGAAGCTCAACCTTTGAAAGAGGAAACCAATTATGCCCTCTTAGTGCTGAAGTTGATGCTGGAAGAACACTGGGGTATCCAGTTCACACCTCTTTTTAGAGAAAGATCTAATTATATAACTGCCCAAAAGGTGTTGAGGAAAGGAACAATATACTTCCAAATCCCAAGAACTGATGAGAATGTAGAGCTACTAAGAGATTACGATGTAACTATCTAAATAATAACAGGAAGAGGGGGGAAGCTCCCTCCTCCATAAAACAAGAAATTATGAAAAAAGAAATTACTATTTCAATGAGCTATGGCAAGGTACAACATCTTTCAGAAGTCCTGCCACTGATTCCAACTAACACAATCCTTTGCAAGACACTTACTGGCATAGGAGCAACTTACGGAGAAATTCGGTCTGCCCGAAACTCTATCATCATAGAGCCGAACAGACCTGTTATATATGGGAAGTGTCGTGCCCCAAAACATAAAAATGACAATCTGTTTGGAGTTTACGAGGGCATCTATACCCAAGACATTGTTAACTACATCATCAAATCCCAAGACAGGAACAAGAAGATAAAGATACTGACCACTCCCGAGAGCTTCTACAAAGTGAGAACAGCATTTGAACAGATGGGGATAGATATTCGGACAGACGGTTATTTCCTATTGTTCGATGAGTGCCAGAAGATTGTTAGAGACTGTGGCTATCGTAAAAACATATCACTGCCAATGGATTTCTTCTTTGAGTGTCAAGACAAAGCTATGGTTTCTGCTACACCTCCATCAGAGTTTGCAGACTCACGGTTTGAGAATTTTGATATTCTCATCATCCATCCCGACTTCAACTACAAAAAAACGATAACGGTTTGTACCACCAACAATGTACTGGAGAGAACACGGCAGTTGTTACTACAACTGGACGAGCGACCAGTTTTCTTTTTCGTAAACTCCACAGACATTATCCTTGCTATGATGGAACAACTTGGATTAAGGGATCAATCAGCGGTGTTCTGTTCTGCCGACAGTGTGGATAAACTGAAATCACAGAAGTTTAGCAACGCACACGAAAACTGGGAGAAGAAATACATGGCAAAATACAACTGGATGACAAGCCGTTTTTACAATGCTATGGATATAGAGTTGAATGAAAATCCAAATGTTGTGATGATTACCGATTGTTACACCGCTGATTACACAATGATAGACCCTTATATGGATGCAGTGCAGATAACAGGGAGATTTCGTAATGGAACTAACGCCATCTACCATATCAGTAATTTCGATAAAAGAATCCCAATAAAAGACAAGAAGAGCATTATCATACGGTATCAATGCGATAAGGAAATATATGAGAACTTTAGAACATTCAAGAACTGTGAAACAGATATCAACCGAAGGGCGGCTTTCAATGATGCTATGAATGTGTTGCCTTACAACAGATTCCTTAACGATTACAGCAAAGAGGATGCTTTCAAGATAGACAACTATATCCACGAAGAATTGGTAAGGGTGATGTACCATGATTATACACGTCTCTATCAAGGATATAATGAATGTGGATATTTTGAAGTAACCACCTCAAACATAACTTATAGATACGGTGATTATGATCGATTGAAAATTACAAATAATACTTTACCTATCAAAGATATACGGAAACGAATTGTAGACCAGTTGGAAGCTCTAAAAGAAGACGAGACAGAAATGGCAATGCAATACCGAGATGAACTTCGTCACATAGATTCTTTCATTGTAAAAGCATGGGAGGTGTTAGGGAAACAGACGATTGAGGAACTTAATTATAATTCTAAATCAATTAGGGAGAAGATAATACTTACCTTACATGAGAAAAAGGCTAAATCTTCAGATGTAATTAGAATGATCTATAATTCGTTTATTTCAAGGCATTGGTATGCTTCTTCTTTTATAAAGCAAGAGCTAAAGCGAATTCACAATTTATTAGGAGTTCCCAAGAGTAAAGCTATCACTGCAAAAGATATTTGTCAATACTTCGAAGTTACAGAGAAACGGAAAGCAAAAGAAAGAGGTTATTACCTCATCAGTCCAAAATTTACTACAGAATGAAAACTATTAGATTAAGATTACTCTTTATAAAGAAACTATCATCCAAATACAATGTGCTCCCTCACATTGAGGATGGATAGAATCACATTGTGCAAGAAGAGATTATGACGAAGATTATGGTAGAGCCTATTATAGGTTTTGAAACATCTGAATTTACTGAATTTGTCAGAGAATACAACTCAAAAGGTTAACATAGAAAATAGGTGATAAAATGTCTAAAAGTGTACAAAGAGATTAGTAAAGTCAAGATAAGGAGAAATACACAGAGATAGTTCAAAAAGGCATAAGTAGCCAACAAGTGAACAGATATGGACCAGAGTCAAAAAGGACTTTTATGATATTGCAAACCATGTTCGTTACTAAATCTATATATAGCTGCCAAACGAGAACACCCCTCCTCCTCTTCTAAAATGTAGATGCTGTAATAAAGGGGATATCCCACTATATACGTCATCCTAAAATATGCCCCTCTTTTGCTATGTCCTCCCTTTATCATCAGAACATAGGTGCTTTATCATCCAAGCATCAGTTATGCAAAACTCACACACAAAGGCATACCCACTTTGTCTCCCCCTCCACACAAAACAAAGGGAAAAGAAAAATAGCAGAGGTTTCTACAGTGAAAAATAGGCTATGAATAAACCTCTATATAATCTTAGGGGATTTATGATGTGTAACAGGCTGGAAGTTGGAGTAATCCGCTTTCGGTCTGTTCTCATTTATGCCTATTTTCAATCAATATTCACTTAATCATTTACAGTTATGAACAACGTAACATTAATGCCTGCTGTTGTGGCACAAAACAACAGAAACTTTGATTTCAGCGATGCAGAGGAAGCCGTTATCATAGAGGACACCCCAACGGAGGGTAGCAGTGTTTCTTTCCTCGAAGCCAACACCAACGCAATCTCACTTGATGAACTTGCCAGTACGTGTGTCGTCCCAACTTGGGGTAATCAAGAACTGACCATTGCACATCAAGACTTTATTAACTGTGTACATGATGCTGCCAAAGACTTCTATCATGGCGAGCAGATAAATACTCCTGCTATCCGTGTTTCTCATATAGTAAGAGGTAGAACACCTAACGCATTAGGCAAGAAAGCGTCAGAACTCTTGGAGTGTGAAAAGACACAGTTCTATCAGCGTATGGCGTTTGCTTTTACTATCCCAACGATTTATGAAACCTTGAATGGTCAGAAGCTTGAACTTTGTGTGGGTGGAGTGCGTAATTACAACGACCTCAACCTTTATAGGGCAAGTAAAGGTGTAGAGAAGTTCTCTATTTTTGTAGGCTGGAGAGTAAACGTGTGCAGTAACCAAGTGCTAACAGGTGATGGTGTCAAACTATCTATCGAGGTAATGAGCATTCGTGACTTATATAAGAGTGTGATGGAGTTACTCTACCACTTTAATCCAGCTAAGGATATACACCTAATGCAGACTCTCTCAAATACTTCTCTCACAGAAACACAGTTTGCACAGATAATAGGCAGAATGAGAATGTACCAAGCCTTACCGCAAGGATATACCAAACAGATACCACGCTTGCTGATTACGGACAGCCAAGTGAACAGCGTATGTCGTGGCTATTACAGCAATCCTGATTTTGGTGCCAACGACGACAGTCTGTCTATGTGGGACTTCCACAATCTGCTTACGGAATCCAACAAGGGAAGTTATATTGACACCTACTTGCAGAGAGCGGTAAATACCACGGAGGTAGCGGTTGGCATCAACAATGCCCTACATGGTGATGAGAAATATAAATGGTTCATTGGATAAGTGAACTGTTGATTGAGAGCGGGGAGACATTCTGCAATGGGTGTCTCCCTTTTTAATTGGTAAACTATACACACAACACGATGAATAAAGAGATAGACAAGGCTCTACACCTTATATATACTTTACAGGAGCAGTTATGCAATATGCCACACAGAGAGGGCTGTCTTAAAATGCTATACCAGATAAGAAGCCTTATGGAGGATTTCGACAGTATGCTGACACCAGACCAACGCAAATACGGTATATACAGCAATGCTTATAAGGAGATATTCGCTAATGGCACAGGTCTTTCGCAATACGACAAGGTTTGTGCAACCATCTGCGAGGAAGAATATGCAGAACTGCCATTTTAACAACAACTTATTCATACATTACAACTATGGACATGGATTTCAAGGTAGCAGAGGTAACGCTACAATACAAACCGACCTGCAAGAAACAAAGCAAGGTTTTTGGTTCAGAGGAAGCATATAATATCTTACTTCCTACATTCAAAGAGGGAACAATAGAGTACAGGGAATATGCTAAGGTGTTATATCTCAACCAAGCAAATGAAGTTATTGCTTATAACACGATTTCAGAGGGAGGACTGACAGAAACTGCCGTTGACGTGAGGATAATACTACAAGGGGCATTACTGACCAATGCCACGCAGATAATATTTGCTCACAATCACCCAACTGGTAACTTAAAGCCCAGCCCACAAGATGATATGCTTACAAGAGAACTACAGAAAGCTTGTCAGATTATGAGGATACGGTTTACTGACCATATAATCATGTCAGTAGATAGCTATTACAGTTATCGTGAAGAAGGGAGGATATTGTGATGGAAACTAATTATGTCGTAATTCTTGATTTCAGTACAGCAACTGTAATTAAGATACATCTATCGAAAGAGCAGATTGAAGAATCCTACAGATATAATGATTTTGAAGAATTCCTCTTTACACTTGAACCCAAATACGGCTTTCAAGTAAAAGACTGCTGTTGGATGATGTGTGAGACATTGAAAGAGGAAAACTACCTCTGATTATATTCACTAATAGAGAAAGTGAACGTTATTCTGATAATCAATCACTTAACAAAGGGGCTGTCAGAATTATGTTCACTTTCCTTATAAACCCAACATAAAAGAATATTATTATGAGTTTGAAATATAGCAACACAACGGCAGACTATCTTGAATGGTCAGAAGCCATGAACTTAATACGTAGACTGACAAAAGACAAGAACTATAAGATTTCGCTTCTTATAGCGATTGGTTGTTTTACAGGATTAAGAATATCTGATATTCTAACCTTACGATGGAAGCAGATACTTGGTGTTTCAGAGTTTACTATAACCGAACGTAAGACAGCTAAGCAGCGAACTATACGCCTTAACAAAGAACTGCAATTGCATATTAAAGACTGTTACGAGCATATCAATCCTCTTGGCATTGCAGCTCCTGTCCTTGTTAGTCAGAAAGGTACAGTTTTCACCGTGCAACGCATCAACGTAATACTCAAAGAACTCAAACAGAGGTACAGACTGAAAATAAAACATTTCAGCTGCCATAGTTTGAGAAAAACATTTGGAAGACAAGTTTATAACATGAATAGTGACAATGCAGAACTGGCACTGATCAAGCTAATGGAGCTTTTCAACCATTCATCTGTAGCTATTACCAAACGGTATCTTGGATTACGTAAGGAAGAAATCTTGGAAACCTACGACTGTCTTACATTCTAAGCAATGACTTTTTTCAGAGAATAATTCTTTTATACACCCCATACTAAAAATGTCATCATATGCTGAATAACAAACAAAAAACACCCTTAAAATAGAAAAATCACTCTGTTATACAAACTTTTTGCAAGAAAGAAACATTTAATAAGAAAATTTATCTATCTTTGCAGTGAACTTCCAGTACGTCTGTGTGTAGATGTGCGTTATAAAGAGTTCAACTTTTAAAAGAGCGTTTTGATATTATCCTGTTGAGAAATCTGGACAATTTCTGTAACTGGGGATAGTGGCAATAACGCTCACGCATGGGATTATTGTACCCTTAACTAAGGGAATAATATACCTCAATGCGTGGGCTATTGTTTATTATTCAGTTACAGGCAGTCCAGAGCCTCTCGACAATAATAACAATAGTTCCCACGCTTTTTCCATTTACCTAAATATTAACCGCTTACTTCTGGGAAACAGTGAGCACAAGATACAAAATTATGAAGTGGTTGACTACCATTATTGTTGTAGCTATCATTGCTGGAATCTTAGGTGCACTAAACTCCAAGGATGGAGAAAAAGGAGAAGGATTCTTTTCTGGTGCTCTTGCTGGAGGAATGGGCTGTGGTTATGTTATCTTCGAAATATTTTTAGTCGTAGGTGGATTGATACTTTTATTTAAACTCTTCGGCTTTTTATTTGGATAAACAAATACAACAATTTCCTGCTATGAAAAAAGGGATATTTAACTTACTATCTATGAGTATATTATTCTTTGCCAACCAAGGGTATGCTCAACAGATTAATTCACATTTACAAGCTAAATCCACCTTACAAAATCATGTCAGTTCCATTTTAAAAGAGAATATCAAAAAGATAGATGCTATTAATGGACAGATAATAATAATGGATTGTAAGTCTGGAGAGATTAAGGCAATGGTAAACTTGATGAATACTAAATCAGGAATCAAGCCAGCAATAAGACAATTGTCAGAACCAACTGCCTTAATGCGTACAGTTTCATTATTAGCAGTATTGGAACAAGGTAAGGTAAACCTGAATGACAGTATTGATACTAAAGCAGGAATGCTTGATATAAACGGCTATCTGCTAAAAGATTACAACTGGCTTAGAGGAGGAAATGGAAAGACAAGCGTACAGCAAGGCTTTTTGTTATCATCAAACATCGCTACATACTTAACAGTTAAGCAAGCATTTGGCAAGGAGTATGACAGGTTCTATAAAGCCATTACCAATATGGGCTATGGTTTACCACAAAATAGCTTCAAAGCAATCTTACCAAATCCCTACAATGATATTTCTCTTGCCAAGTTTGTAAATGGAAAGAATCAGCAGATATCACCTTTACAGATACTTACATTTTATAATGCCATAGCCAATAATGGTAAGATGGTAAAGCCCACTTTTCATAAGAAGGATACTACCATTATAAAAGAACAAATAGCAAGCAAGGAGAATATTGCCACTATCCAGCAATTACTTATACAAAAAAGACTTACTACCAAAGTCTTCTCTGATAAAATCCCCATTGTGGGAGAACAAGGAGTTGCCATTGTAAAGGAAGATGGAGATAACACAGTTTACTGCTTACAGTTCTGTGGCTACTATCCATCAGACAATCCACAATACAGCATCATCGTTTCTTTGAATAAGAAAGGATTATCAGCAAGTGGTGGAATGGCAGGAGAAATAACAAAACAAATAGTAGAAACAAACAACTTTTTTTGATAGTATGAATATCTATTTAATAAACCCTAAGTGGATTGATTCCACTAAATTTCATAGTTTTCTTGAGATATTAAAGGTAAAAACAATAATCAGTTTTATAAACGAGGAAGATTACACTAAAAATTTACTGCCCAAATATACAGCAATAAAAGTTCTTGATTTCGCTAAGACTCCATTAAGGATGTATGGTAATAACTTTGAGTATAACAAAAAAATAGTTGATAAGTTCTTACAACAGGCTGTATATGAGTTTATTAGCCCATTCTCCCAATTAGCGAAAGATACTAAAGGGAAGATTTCAATATGCAAAGTAAACGATGCATATAAGCAAAGCACATTTAATAACCCTATCTACAATATTGAAAAACTTAATGATCCTAATATGTTGATTCTTTATAATAGTTATAAAAATGAGCATCCTTTGTATCGTGCTGTAGCAAGATTCAAAAGATATGCTTTTAGCATACTTGACAAATATTGTCCACAATTTGATTATAAACATAGAATCGCATTCGTCAGTTTTGATGAGTTCTTATTTTCTAATAGTGTATTCTCTAATAGTGTAGGAAATTCAGATTATTTCTTCAGGACAAAGTATTATTCTATATATTCAGCAAATAAAATAGATGATTTATTCTGTCCAATGCTTGTTTATCTAAATCTGAAGGCAAATCAAACCCACTATAAAGAACAAACACTACAAGAACTTTTCTTGCGGGATGGTGCGAAACGAGCTATGGAGAAATTTGTTATTGAAAGCCGTGATGCAGAATTACTAAGCAAAAGTTGTAGTTATGATTGCGATGATTCTAACGATTGGGGACAAGAGGGTGAGTTAGAATATATATATGAGAATGGCGGAGATTGGATATTAGATTAACAAATAATATAAAATATATGAAAAAGATAGAAACGCAAGAAGGTGTTTACATCATTCAAGAGAGGGAACACTATGGCATCATCAACGAAAATAATACCATAATAATTCCTTGCATATATGAGTCTATAGAATATATTCCTACTGACAACATATATCTTATAAGATTAAATAAAAAGTATGGTGTTCTGAATACCAATTTTAAGACTATAGTTCCACCTGTTTACTCTGGATTATACCTATGGGGGAAAAAGTTTATTGCAATCATTGCTGGTGGACTTTCTGAAAACTTCAACTGGCTTTGGATTTATCAAAAAAGAAAAAGTCACAACGCTTTTTATAATCCTAAATATTCACTGTTAGATAAAGATGGACAAGAAATCTTCCATCCACGCTATGACACAATTACACCTGTTGACGAATCATTTGCTACAGTAACACTTGGAGATTATATTGGCTTGATAAATAGTTGTGGAATAGAAATTATCCCTCCTATATATGATATGGAGAAAGATTCTATGATAGAAAAAATAGCAAATGGAATCGAAGAACTAAAGGGTCGAATTCATAATAAAAGCAATAGATATTATCGCTGGGAACTTACCGATGGAAAAATAAGAGAAAAGAGAATATTTTGTTTTTCCCAAGGGAATACTTTATACGTCATGGATGAAGAAGGCACTGTTTTTGGTAGTCAACAATACTTAATCATCCCAAGGTTTGATAAGACTGATAGTATTTGTAATAAAGACATCATAAATTTGTTAAGTAACAATGATACAGAAAAAATACGCAAACAGGATTTTGATTTTAGCAACATAGAACTATTCCGATAAGGATCTCCCAATTAAGAGGGTTATTTGCACCATTTGAGCAATCATTTGGTGCTTTTTATTTTATTCTCTTGCAACTCTCAAAAGAAAAGATTATATTTGCAATATAAACGAAAAAAAGGAGGACTAGTAATGAGTACAAATAACACCACAACAAGCACATCCTCTTTGGAAATCTCAAAGTGGTATCTTGCTTTAACTCACTCATGAAGAGCTCATAACCTACAAATATGTACTTGAAGCCAATAAGCAACAGCGTGTCAAAAATATGATAATGTTGATAAATTATTTGCTTCCTTATAATGGAATATAGGTTTAACACAATTCTAGTTTTGCCAACCTATTATTTCAACATAAAAGGAAATAAGGTAACACAAATATTGTTGGGAATGTTTTAATATAAACCTTTAGAGAAAAATGTCTAAGCAAAGAGTTTCAATTACAGATAATAGTATCAAAAATGGAGTGACGAATGATGCTAAAAAAGCTATATGTGAATTTATATGGAATGGTTTTGATGCAAAAGCTATTCATATTAATATTGAATACCAATCCACCGAATTAGGTGCAATAACTCATCTCTATATAATAGATGATGGCGAAGGAATAAATCGCAGTCAACTGAATGAGACATTTGGAAAATATCAAGACTCAATTAAAAAGCGTTCTTTCCAATGGAGTTCACAAGTAAAAGGACATAAAGGAAAGGGAAGATATGCTTTCAACTGTTTTGCAACTCGTGCTGATTGGACAAGTATTTATAGTGATGGTAAGAATTTGATTAAACACACAATATCAATCAATGCTGGAGACAATCATCATTTTAATGATCATAGCGACTCAGATAAAAATTATATTGTTCATAATGAAAAAACAGGAACCATTGTTTCATTTGCAAATGTTTCATTAAACCAATCCTTTTTTGAGTCAAAAGAATTTGTTGATTATCTAAAAAAAGAATATGCCGTTTTCCTAAAATTGAATGGAAACAAAGGTAAATCTATCATCATAAACGGTAAAGAATTAGATTATAATACAATTATTGCAGATACGGATAATAAGGAAATACAAATTAAGGATGAAACAAATAATAAAAACTATCATTTTGAATTAACTTTTATACGTTGGAAAGAAAAAATAAAAGAGAATTATAGTTATTATTTTCTAGATAATGGGCAGATTGAGCGCTTCGAAAAAACAACATCCCTTAATAGAAAAGATGTTGGTTTTCATCATAGTGTCTATATAATTTCATCGTATTTTGATGAATTTCATCCAACTTCGAGAAAAAGCCAAGATATAGATGAGGAATACTCACAACAGGAAATTACCTTTGATGAAACAAAATTTTCTAAGTCAGAAAAAGATAAAGTTTTTAAGCAGTTAATTAAAATAGCTGGTGTTTGGCTAAATGAAAAACAGAAAGAATATATTTCGTTAGTAGCAGGTGAGGAACTATGGCATAGATTTGAAAAGAAAGGGATTGTTGCTTATCCAAAAAATGAATATGAGCTTCCTCTCTATTTAGAATTAAAGAATACGGTAACAGGAATTTACTCTGTCCAACCAAAAATATTCGAAAATATTAGAGAGAAGCCAGCTAAAACACTGGTAGGCTGTTTAAAACTATTGTTACAGACAGATAAACGCGAAGATTTGATTTCTATAATAGATAGTGTTGTTAAAATGTCCGATGATGAGCGACATAAGTTAGCAGGTATTCTCAAAGTAACAGAGTTGTCGCATATTACTAGTACAATTGGACTCTTAGAAGATCGATTAAAAACAGTGTCTGCATTAAAAGCTATGCTTTTTGACAAAAGACTAAAGGCTTATGAAGTTAAAGATATTCAAAAGATAGTTTCGAGTGCCTTCTGGTTATTCGGTGAACAATACAATATAGTTACGGAAGCAGAGCCAGATTTTCAGCAGGCTTTAGAGGCATATTTAAATGCATTACACAATACTACAGCTGGCGTTGGAAAAAGTAAAGTTAGTGTGGATAAAATGCGTAGTCCAGATGTAAATAAAGAAATGGATATATTTGCTTTCCGCCAAACAAGAAACAGTAATACGGTAGAAAATATCATTATAGAATTGAAGAGACCATCAGTAAAACTAGGGGAGCTTGAATTGAGCCAAATAAAAACTTATATGAGGACTATATATCAAGAGCCACAGTTTTGTTCTGCAAGTGCAAAATGGACGTTCATTCTCGTAGGAAATGAATTAGATAATAGCGGAAGCATTGAAACAGAATACGATTCTAACAAGACATGGGGGAAGAGGGATTTAGTTTTACATGTTGATAAAAACTCTCAAAGATATGAGATTTTCGTTAAAACATGGAGCACTATTTTCGATGACTTTGAAATAAGACATGATTTTCTATTAAGGAGGTTAAATTTTCGACGTCAGGAACTGTCTGCACAATACTCTAATAAAGAAGATTTGCACAACATCGTAGATTCTGCCAAGGAGAAATAAAAAGACAACATCCTATGAATAAAATCATTTAGTGCTTTTTCGTTGATGACATTTTTACTCTGAAAATTATTATATATACCCAAATGTAAAAATGTCACTCCAAACGAGAAATTCTGATTTTAAGTACACTTTTACTCGATTTTTCAGAAAAGTGCGAAGCAGTTTGGATTTACAGAATAAGATACCTATATTTGTTTTAGATATTCAGGTAATCCCAACGATATAAAGGAAATATGGAGGTGCAACAATGTACCTCTTTATTTATTGCTTGAAGTGTCGATTTTTTATTTATAAGCCACTACAGATAAAATTGAAGTACAGATATACCTAATGAAAGAAAAACACATTACCAATGAGAGCCGTATGGGAATTGCCAATGAGAGCAATAGATACTACTAATAAAAAACTATTACTCATACAGCTCAAATCTTTCAGATTTTCGCTTATCTAAACTTATTGATTTAACAATGGAACATGATTATAAAAGTAACAACAGGAGAACAATTTGAAACCCGAAAAGAAGCCAAAGAACGTGTTGGAGGCAAATGGGCATTTGAGAGATTAGTAAAAAACGGAGAGATAAGATTTATAAAGGATGGTAATAACATAGCAAGCGATGGATTACACTACCCTAAGCAAGGAAATCGGAGCTTGTCTTAATCCACTGCAAGCATACATATACTTGGGATTATGCCTACATACAGATTTTAAGAATGATATTTCAAATATTAACCAAGATACGTTGGCAAAGTTCCTACAATGTGATGTTGGTGCTATACAAAGAGCCTTACGAGTGTTTCAAGAGAACAACTTGCTTACCATTCATCAAGACAAATATGGCTGGAGAGAGAAGAACAGATATAAGCTAATTAGAACTAACTGGTTTGGCGTTAAAAGAAAGATACTGGAAGAAAACATAACAAGAGAACAGATAGGCTTTCTCTTATTGTTGAAAAGTCTTTGCTACAACCACTGTAATTATACTGATTACTATGGCAAGGGCTTACAGGAAATAATGGCTCTTAAACGGAGCATGATTGACAATTATTTGAGGGTATTGGAAGCCAAACTATATATCAAGAGAGATAAGAAGAAGAAACGGATAACAATACTCCGAGATGATTTATTCCTAACAACAAAAGAATCAGAGAAAGAGAAAATTATGAAACTATGCCCAGAGTTAATGGGCGATGATGATTATATTGATGAACATGGACACTACCATTTTGTAGACTAAAATCAGCTATGCCCTACATCAAGTTTATAAAACTGGAAACAGGGTTACGAATAAAGAACTGAAAACCACCTTGCAAAAGATTTACACAGGATTTGGCTGTAAGAGAAAGGCAAAAGGAACATAGATTACAGAATATGGCTTCGCCACGCAAAGATGTAAAATCCCTACAGATAAGGGGAGAAAAGATGGAATGATATTATTCACAACATAACTACAGGCAATGATAACAAAAGAACACTTATAGGCACTCGTCAACGAGGCTAAAAGTCTTGTTGACATATTGAAGATACTGAATAAGAGGCAGAGTAAAACTAACATAGAAGAGCTTACTACTTTATTAGATAAATACGGTATAGATTATCATACTCTTCCCATTAGACTGATACAAGAGAAAATCCCCTTAAAAGATATACTTGTAGAAAACAGTACTTATCAATCTTCCAAACTAAAGAAGAGGCTGATTGAAGAGGGTATCAAAAAGGAACATTGCGAAATATGCGGACAAGGTAACACCTGGAATGACAAACTGCTTGTCTTGCAATTAGACCATATCAATGGTATACACACAGATAACCGATTGGAGAACCTGCGCATTGTCTGCCCAAACTGTCACACACAAACAGATACGTTCTGTACTCGAAAACTTAAACAACACAACTACTGTAAAGACTGTGGAAAAGAGATTACTCCTAAGTCTACTTGGTGTCCCAAATGTGCATTGAAACATAACCGTGTACACAAGGTTTCACCCTCTGATAAGCCCTCCAAGGAAGAGCTACTGCAGCTAATAAAAGAGAAACCATTTACCGAAATCGGTAGAATATACGGAGTAACTGACAATGCTATCCGTAAATGGTGTAAAAAGATGGGACTACCCTCCACGAAAAGAGAGTTAAACGCATTATATAAGAAAAACACAGATAGAGGATAAACAGCCATACCTCCTATTTCAAAGTGTGAGATTATTTTCACACAACTGACCTAAATATGTTAGTTTAGTACAGTATTATTCAAGATATTTTTGTAACTTTGTGATACGATAGAGCGTTGACCTATAGTTGACCTCTTATTCGCACAGAGTTCATTAACAAGCTGATAAATAAGCTCATATATAGTTTGTGTGGCGAGACTCATAATCTGGAGGTCCCTGGTTCAAGCCCAGGCTGGTCCACAAAGGGGTTTCAAAAGGATGTCAAACAACACGTCATTTTAGCCTTCAAAACAAGGATAATCGCTGTAAAATCAAGGTTTTACAGCGATTTTTTGTTTTTTATCCATATCCGTTTGACTGCCAAACTATACCTTTTGATAGTCATCATTCGGTCATTTTCTGCTACAGAAATTGCTACACAAAAGCAGGCTCTCAAAAAAATGTAGCAATGAATGGAAAATGACTATCAAATTGACGGCATGCAAAACTTTCGTTTTCAAGAACTTATGTCGAACTTTGTAGCCAAAAAGCTACACTAAAATGATGTGTTATGAAAACGACTTTCAAGGTATCCTACTACCTACGTTCCAACTATGAGAACAAAGAAGGAAAATCACCTGTAATGCTCCGAATATATCTCGGTGGCGAAAAGGCAAATCTTGGATCCACTAAAATTTTTGTGGATAAATCCAAGTGGAGTAACAAAACCAGCAGAATGATTGGCAGAACAGCAGAAGCACTCTCCATTAATGCTTCTATAGATGCACTGACAACAACACTAATGCAGATTTACAGGAAATATGAAACATCAGAGGAACTTTCCATAGACCTTATCAGGTCAGTATTCCTTGGTACAGACAAAGAATATACAACTTTTCTGCCAGTCTTTGACAAGTACATAGACTCCATCACACAACAAGTTGGTAAGACATTAACAAAGGGTACTTTTTATAAGTATAAGGTGGTGAGGCAGAACTTTCAGGATTTCCTACAAGCAAAGTATCATCGCAAGGATATTGGACAGACAGAACTGACAAGTGCCGTTGTTCAGGACTTCGAATTATACCTTACATCTGTTGTAGGTGGTGTGCATAACACAACCACCAAGAAATTGAGAAACCTGAAAACGGTCGTGAACTATGCGAGGAATAGAGGACTTATCATGCATGATCCATTTGCGAATCACAAGCTGCGCTATGAATTAGTAGATCGTGGCTACCTCACAGAAGAAGAGGTACTCCGTATTATGAAGAAGCACTTTGACATAGAACGGCTGGAGTTAGTAAAGAATATTTTTATTTTTTCCTGCTTCACAGGATTAGCCTACATTGACGTATATAATCTTACCTACGATAAAATTGTTACCGTAGAAGACAGACAATGGCTTATCACCAAGAGATACAAGACAAGCGTAGATGAAAACGTCATGTTACTTGACATTCCACTTGCCATTATAAGAAAGTACTACGACATCAATAGAAAAGGGGGGAAAGTCTTTCCTATGATGAGCAACCAGCGTATCAACTCATATTTGAAAGAAATTGCCGACCTTTGTGGCATAAAAAAGAATCTGACCTTCCACATGGCAAGGCATACTTTCGCCACTATGTCTATATCCAAAGGGGTACCAATGGAGTCTGTATCAAAGATGCTTGGACATACAAATATCAGAATAACTCAGATTTATGCACGAATAACAAACAAGAAAGTTGAACGTGACATGGAAGAACTGGCTGGAAAGCTCAGTAAGTTCAATACAGCCATGGGCATATAA

Protein sequences of DBSCAN-SWA_1

>CP022041|220916:251291|230632_231460_-|ASE18099.1|protease|DBSCAN-SWA
MNNKNVLSATLYVILFVSLFILIQSLSFKGGKELVSLLGGTEAADGDYLTKNGETLAITAVISSLATLILFIATKWAPVSGNYLKTRPWAVLMWSALIALGSILPLQFLAEKINLTMPAGTEEMFESIMKVSWGYVALGLMVPIAEEIVFRGAIQRVLQNVLGERKRWIAIVVSALIFGIIHFNLAQGLHAFLIGLLLGWLYSKTGSILPGFVFHWVNNTVAYLMFNLMPQMNDGKLIDFFHGNDRMMYGGLFFSLCIFVPALFQLWVRIEKGNN
>CP022041|220916:251291|248863_249517_+|ASE18115.2|DBSCAN-SWA
MLKILNKRQSKTNIEELTTLLDKYGIDYHTLPIRLIQEKIPLKDILVENSTYQSSKLKKRLIEEGIKKEHCEICGQGNTWNDKLLVLQLDHINGIHTDNRLENLRIVCPNCHTQTDTFCTRKLKQHNYCKDCGKEITPKSTWCPKCALKHNRVHKVSPSDKPSKEELLQLIKEKPFTEIGRIYGVTDNAIRKWCKKMGLPSTKRELNALYKKNTDRG
>CP022041|220916:251291|242162_243152_+|ASE18892.1|DBSCAN-SWA
MSILFFANQGYAQQINSHLQAKSTLQNHVSSILKENIKKIDAINGQIIIMDCKSGEIKAMVNLMNTKSGIKPAIRQLSEPTALMRTVSLLAVLEQGKVNLNDSIDTKAGMLDINGYLLKDYNWLRGGNGKTSVQQGFLLSSNIATYLTVKQAFGKEYDRFYKAITNMGYGLPQNSFKAILPNPYNDISLAKFVNGKNQQISPLQILTFYNAIANNGKMVKPTFHKKDTTIIKEQIASKENIATIQQLLIQKRLTTKVFSDKIPIVGEQGVAIVKEDGDNTVYCLQFCGYYPSDNPQYSIIVSLNKKGLSASGGMAGEITKQIVETNNFF
>CP022041|220916:251291|245279_247349_+|ASE18113.1|DBSCAN-SWA
MSKQRVSITDNSIKNGVTNDAKKAICEFIWNGFDAKAIHINIEYQSTELGAITHLYIIDDGEGINRSQLNETFGKYQDSIKKRSFQWSSQVKGHKGKGRYAFNCFATRADWTSIYSDGKNLIKHTISINAGDNHHFNDHSDSDKNYIVHNEKTGTIVSFANVSLNQSFFESKEFVDYLKKEYAVFLKLNGNKGKSIIINGKELDYNTIIADTDNKEIQIKDETNNKNYHFELTFIRWKEKIKENYSYYFLDNGQIERFEKTTSLNRKDVGFHHSVYIISSYFDEFHPTSRKSQDIDEEYSQQEITFDETKFSKSEKDKVFKQLIKIAGVWLNEKQKEYISLVAGEELWHRFEKKGIVAYPKNEYELPLYLELKNTVTGIYSVQPKIFENIREKPAKTLVGCLKLLLQTDKREDLISIIDSVVKMSDDERHKLAGILKVTELSHITSTIGLLEDRLKTVSALKAMLFDKRLKAYEVKDIQKIVSSAFWLFGEQYNIVTEAEPDFQQALEAYLNALHNTTAGVGKSKVSVDKMRSPDVNKEMDIFAFRQTRNSNTVENIIIELKRPSVKLGELELSQIKTYMRTIYQEPQFCSASAKWTFILVGNELDNSGSIETEYDSNKTWGKRDLVLHVDKNSQRYEIFVKTWSTIFDDFEIRHDFLLRRLNFRRQELSAQYSNKEDLHNIVDSAKEK
>CP022041|220916:251291|224524_224905_+|ASE18094.1|DBSCAN-SWA
MRKTTDILLSLLLSTMIVWIGSGIMTVVCAHTGNVSVAKMEDKGHCNDNGVKNCMKIEVKSLSPTDMAHNDFYQIQPIQLSLLPQFVSDCQLLPLPVLTKAPERILSLLWHSPPRQYLRLLTTLII
>CP022041|220916:251291|243156_244032_+|ASE18111.1|DBSCAN-SWA
MNIYLINPKWIDSTKFHSFLEILKVKTIISFINEEDYTKNLLPKYTAIKVLDFAKTPLRMYGNNFEYNKKIVDKFLQQAVYEFISPFSQLAKDTKGKISICKVNDAYKQSTFNNPIYNIEKLNDPNMLILYNSYKNEHPLYRAVARFKRYAFSILDKYCPQFDYKHRIAFVSFDEFLFSNSVFSNSVGNSDYFFRTKYYSIYSANKIDDLFCPMLVYLNLKANQTHYKEQTLQELFLRDGAKRAMEKFVIESRDAELLSKSCSYDCDDSNDWGQEGELEYIYENGGDWILD
>CP022041|220916:251291|241903_242110_+|ASE18110.1|DBSCAN-SWA
MKWLTTIIVVAIIAGILGALNSKDGEKGEGFFSGALAGGMGCGYVIFEIFLVVGGLILLFKLFGFLFG
>CP022041|220916:251291|221376_222246_+|ASE18092.1|transposase|DBSCAN-SWA
MDHAQDWLLFEDNIGESLSIDETCLSCGEVYTFLTNKAGKGREGTLVAVVKGTKAEDVIQILKKINLSKRKTVKEITLDLSSSMMRIARAVFPKALITNDRFHVQKLYYDALDDMRIAYRWMARDKENEEIKEAKCKGKEYIPFRYSNGDTRKQLLARAKFILTKHKTKWTETQKGRAEIIFEHYPTLKKAYDLAMKLTDIYNIKSIKDAARLKLAKWFNEVEELGVDNFYTVIDTFENHYQTILNFFVNRATNANAESFNAKVKAFRAQFRGVTDIPFFLYRLMKLCA
>CP022041|220916:251291|240516_240720_+|ASE18108.1|DBSCAN-SWA
METNYVVILDFSTATVIKIHLSKEQIEESYRYNDFEEFLFTLEPKYGFQVKDCCWMMCETLKEENYL
>CP022041|220916:251291|249702_249963_+|ASE18116.1|DBSCAN-SWA
MCGETHNLEVPGSSPGWSTKGFQKDVKQHVILAFKTRIIAVKSRFYSDFLFFIHIRLTAKLYLLIVIIRSFSATEIATQKQALKKM
>CP022041|220916:251291|222731_224462_-|ASE18093.1|DBSCAN-SWA
MFRSFFNRSFYESVSIILVALLLSSIARRNLSLTRRHIQRCAVDVTEKSYYQLDVDGKPAAYFSNYTDSTFVDGSLPGDSIRSRMSVTEGYWVNKLPILPSCFGRIAVIRRHYPSTIINLKDQKLRQVLMYALMKMDIKLVGLQSKRNETAYYLRVHSVQDYGYNKIADYHTAVVHQIDSLQRIIHVLQDIKPTARLRIRQLSQYTARVWYKPGEIMVCNRLNDESNRWALCLQTSDCMTPWRISSRFGRERGMQESLRHFKAYSHPVLGFPAGALIDSAGYYVGEQRGGKAEGYGQYYGNDGSFYDGHWQDGKRNGFGINVAPHDFLKVGEWKNNVFKGERLTYNADRIYGIDLSKHQHEKGEQRYSIAWSKLRITHLGTLSNKKVKGIVDYPVSFAYVKATEGRTLLNSYYYSDYLAARQQGIRVGSYHFFSTLSSGYMQANFFLKKARFRKGDLPPVLDVEPTDAQIHAMGGAEVLFKQVRIWMSMVFKHTGHRPILYISQSFANRYMPLAPDLGDNYHIWIARYGEYKPNFKLAYWQLSPDGKVRGIHGDVDINVFNGYRNQYEEFLKRHCF
>CP022041|220916:251291|239768_240041_+|ASE18106.1|DBSCAN-SWA
MNKEIDKALHLIYTLQEQLCNMPHREGCLKMLYQIRSLMEDFDSMLTPDQRKYGIYSNAYKEIFANGTGLSQYDKVCATICEEEYAELPF
>CP022041|220916:251291|250067_251291_+|ASE18117.1|integrase|DBSCAN-SWA
MKTTFKVSYYLRSNYENKEGKSPVMLRIYLGGEKANLGSTKIFVDKSKWSNKTSRMIGRTAEALSINASIDALTTTLMQIYRKYETSEELSIDLIRSVFLGTDKEYTTFLPVFDKYIDSITQQVGKTLTKGTFYKYKVVRQNFQDFLQAKYHRKDIGQTELTSAVVQDFELYLTSVVGGVHNTTTKKLRNLKTVVNYARNRGLIMHDPFANHKLRYELVDRGYLTEEEVLRIMKKHFDIERLELVKNIFIFSCFTGLAYIDVYNLTYDKIVTVEDRQWLITKRYKTSVDENVMLLDIPLAIIRKYYDINRKGGKVFPMMSNQRINSYLKEIADLCGIKKNLTFHMARHTFATMSISKGVPMESVSKMLGHTNIRITQIYARITNKKVERDMEELAGKLSKFNTAMGI
>CP022041|220916:251291|244049_244865_+|ASE18112.1|DBSCAN-SWA
MKKIETQEGVYIIQEREHYGIINENNTIIIPCIYESIEYIPTDNIYLIRLNKKYGVLNTNFKTIVPPVYSGLYLWGKKFIAIIAGGLSENFNWLWIYQKRKSHNAFYNPKYSLLDKDGQEIFHPRYDTITPVDESFATVTLGDYIGLINSCGIEIIPPIYDMEKDSMIEKIANGIEELKGRIHNKSNRYYRWELTDGKIREKRIFCFSQGNTLYVMDEEGTVFGSQQYLIIPRFDKTDSICNKDIINLLSNNDTEKIRKQDFDFSNIELFR
>CP022041|220916:251291|238665_239688_+|ASE18105.1|DBSCAN-SWA
MNNVTLMPAVVAQNNRNFDFSDAEEAVIIEDTPTEGSSVSFLEANTNAISLDELASTCVVPTWGNQELTIAHQDFINCVHDAAKDFYHGEQINTPAIRVSHIVRGRTPNALGKKASELLECEKTQFYQRMAFAFTIPTIYETLNGQKLELCVGGVRNYNDLNLYRASKGVEKFSIFVGWRVNVCSNQVLTGDGVKLSIEVMSIRDLYKSVMELLYHFNPAKDIHLMQTLSNTSLTETQFAQIIGRMRMYQALPQGYTKQIPRLLITDSQVNSVCRGYYSNPDFGANDDSLSMWDFHNLLTESNKGSYIDTYLQRAVNTTEVAVGINNALHGDEKYKWFIG
>CP022041|220916:251291|233008_234277_+|ASE18101.1|transposase|DBSCAN-SWA
MLTIKAEIQRDKLRQDGSYNVRIRFTKDRKVKRISTSLFATKADLTDRFTIKEDSLIKQEADILILHYRKMFNEMHLETEALDVNEIVARLTSREESDKPVDFIQFAKGWIANSTLKGAVNYTSALNSLIRFNKSDKLYTHQITSEFLQEFMAFLLNESKERAEQLKKKGKRVPSTRSTSLYLMSIRRLFKEAVKQYNKPDQGLIRIRNTPFVYFQIPKQEATRKRAITAELIRKIEQLPYQTVYKGIHHTNRFNLAKDCFILSFCMIGINSVDLFNATEYDGNTITYYRTKTRDRRMDKAKMIVTVPKMLHPLFEKYKDTTGKRIFNFYQNYVNEKAFNKAINKGLKEIGSILKIEDLEYYAARHSWATIALNKVGVSKYVVHEALNHIDESMRVTDIYIERDFSNENKANAKVVKYVFGK
>CP022041|220916:251291|247965_248586_+|ASE18114.1|DBSCAN-SWA
MDYTTLSKEIGACLNPLQAYIYLGLCLHTDFKNDISNINQDTLAKFLQCDVGAIQRALRVFQENNLLTIHQDKYGWREKNRYKLIRTNWFGVKRKILEENITREQIGFLLLLKSLCYNHCNYTDYYGKGLQEIMALKRSMIDNYLRVLEAKLYIKRDKKKKRITILRDDLFLTTKESEKEKIMKLCPELMGDDDYIDEHGHYHFVD
>CP022041|220916:251291|230016_230373_-|ASE18891.1|DBSCAN-SWA
MKTISKEIDSRYSACPIRQVITRIGDKWSMLALYILGKAGKEKMRYSEIHSYMLDCSQKMLSQTLKNLEKNKLVNRKVYPEVPPRVEYGLTELGRSFLGPLDALFDWGTKNMDKMVKD
>CP022041|220916:251291|236094_237903_+|ASE18104.1|DBSCAN-SWA
MKKEITISMSYGKVQHLSEVLPLIPTNTILCKTLTGIGATYGEIRSARNSIIIEPNRPVIYGKCRAPKHKNDNLFGVYEGIYTQDIVNYIIKSQDRNKKIKILTTPESFYKVRTAFEQMGIDIRTDGYFLLFDECQKIVRDCGYRKNISLPMDFFFECQDKAMVSATPPSEFADSRFENFDILIIHPDFNYKKTITVCTTNNVLERTRQLLLQLDERPVFFFVNSTDIILAMMEQLGLRDQSAVFCSADSVDKLKSQKFSNAHENWEKKYMAKYNWMTSRFYNAMDIELNENPNVVMITDCYTADYTMIDPYMDAVQITGRFRNGTNAIYHISNFDKRIPIKDKKSIIIRYQCDKEIYENFRTFKNCETDINRRAAFNDAMNVLPYNRFLNDYSKEDAFKIDNYIHEELVRVMYHDYTRLYQGYNECGYFEVTTSNITYRYGDYDRLKITNNTLPIKDIRKRIVDQLEALKEDETEMAMQYRDELRHIDSFIVKAWEVLGKQTIEELNYNSKSIREKIILTLHEKKAKSSDVIRMIYNSFISRHWYASSFIKQELKRIHNLLGVPKSKAITAKDICQYFEVTEKRKAKERGYYLISPKFTTE
>CP022041|220916:251291|229176_230010_-|ASE18098.1|DBSCAN-SWA
MVNTSYSNTTTQILKVKTEQVAYRQLGDVKNPPLLCLNHLAATLDNFDPAIMDGLAEHFNVIGIDYVGVGKSTGKSRLTIEEMADDVIDFAEAYGLKDIRLLGFSLGGFVAQQVLLRAPALTTKAILAGTGGAGGVGIKNVAKITYWDMFRAFLTGRDPKYYLFFPMIEQGKKAANNFLKRIARTEDKDDKIKLSSFQRQLRAIDVWGSREKDDLSKIKIPVWVVNGDNDRMVPTPNSYDLAERLPNAHLTIYPDAGHGGVFQYHEVFVPEAIEFFK
>CP022041|220916:251291|235480_236044_+|ASE18103.1|DBSCAN-SWA
MNNKTLDLRIDNAETSASTGTQNNKSMNKGTFTLPTLQKAQNQYDNIGAYNQLQAMMKAGQKLSVKFYTGKGNKPCAWIESKQVTGFRYEVKDTSFKGLMNYLISGEVADFDTSPMEAQPLKEETNYALLVLKLMLEEHWGIQFTPLFRERSNYITAQKVLRKGTIYFQIPRTDENVELLRDYDVTI
>CP022041|220916:251291|231471_232443_-|ASE18100.1|DBSCAN-SWA
MNTIYIKRDEAHELVEQVATIGFFDGVHRGHQFLISRVIDEAERSGMASAVITFDRHPRQVLQADYQPELLSTLDEKLLLLSKTHIDNSFVLHFDASLAALSAHDFMQEVLCKQLNVKKLIIGYDNRFGHNRSETFEDYVQYGKEMGIEVIRADAFLPNDEKVSSSVIRNDLRAGNIEAANRLLGYPYTIESRIVSGYQNGRKMGFPTANLDVNGCQQLLPASGVYAVMVRLKDSVEWKRGMMNIGHRPTFNGTTTSIEVNLFNFTGNLYGQELLVSFISKIRDEHKFDSLEALAQQLKQDKEQINRLFDETYHIQENIINTP
>CP022041|220916:251291|234407_235283_+|ASE18102.1|DBSCAN-SWA
MTFEINKTEYIAVIAGMDCLPRINEDEIIDPSYIELAQKAATDHFANRFSKLFKDNQEKYELFLGNNHIQKQLSKWQLDPIKFWYLHLFIIDYATDAFRSVTIFEELSTKQYIEKLIKSLEKTDIENFCLDIRINKEKLSTRNPWVGEALLSALKQDFPFDWVNNNTFVSKDIKEDIERYTTARMKFSTELYSHFFDQYLHKSQRGRKSFIGKFLYLADLTRDERYWYGCKPTLEKVCKKYEIAQYQKIMVEGVEHIAIPFDVGKDLSDHIKKCTMIPQVRHSFYFSPVDE
>CP022041|220916:251291|227206_227536_+|ASE18096.1|DBSCAN-SWA
MKKAIFTMLMLMVAMIATAKDIKTVIFTTTPQMHCANCEAKVKNNLRFAKGVKEIKTSVEEQKVYVTYDAQKTNEEKLQKAFEKFGYKAEKTTKEAKIPVHENEECENM
>CP022041|220916:251291|240067_240517_+|ASE18107.1|DBSCAN-SWA
MDMDFKVAEVTLQYKPTCKKQSKVFGSEEAYNILLPTFKEGTIEYREYAKVLYLNQANEVIAYNTISEGGLTETAVDVRIILQGALLTNATQIIFAHNHPTGNLKPSPQDDMLTRELQKACQIMRIRFTDHIIMSVDSYYSYREEGRIL
>CP022041|220916:251291|225063_227112_+|ASE18095.1|DBSCAN-SWA
MNKIIYLAGLTLLSVLPATAQEAAVDTTATMKDQTLDNVTVTTRRASVHSLAGAINGKDILRDELFKAACCNLGESFVNNASVDVNYSDATTGAKQIKLLGLSGTYVQMLTENLPNFRGAALPYGLGYVPGSWMKSMQVSKGNTSVKNGYEAMTGQINVEYVKPEDPTGMSVNLYGNTVGRFEANADGNIHINGNKNLSTEILAHYENNWLHHDGNGDGFQDAPKVRQYNLQNRWFWKKGDYILHAGLSLLKEDRVSGQTPHAAATNPYRIDIGTDRYEAYMKHAFVLNKEHATNIALMGNVSMHKQQAQYGIKQYDVNEKNAYASLMFETNFTDEHNLSAGLSLNHDYLHQTLTLPATAVPSDYGNIYPLTRGIESETTPGAYVQYTYNLHSRFIAMAGLRVDHSNVYGTFFTPRFHLKWVPADFLTLRLSAGKGYRSPHALAENNYLMASGRRLIIDKLDQEAAWNYGASLNFNIPIGNKMLKINTDYYYTHFLSQMLIDYDSNPQELHITNLNGKSFSHTFQIDASYPLFKGFELTAAYRYNLVKATYGGKLMWKPLQSRYKGLLTLSYKTPLGVWQFDATAALNGGGRMPESYTLASGERSWAGSYKAYGQLSGQVTRYFRHFSLYIGGENLTNYKQKNPIIGYQNPWANSFEPTMVYGPVEGAMAYVGIRLNLGKRQ
>CP022041|220916:251291|220916_221261_+|ASE18091.1|transposase|DBSCAN-SWA
MKNHQLLRCIFPDVLADYFDVVDIQESVSQIDFWLDERNFMEKSDHKLGTVSSYGFTSERVIQDFPLRGKAVYRHVRRRKWRDSSNGEIFTYSYDDLTAEGSRLSPEFVSFLKE
>CP022041|220916:251291|240833_241421_+|ASE18109.1|integrase|DBSCAN-SWA
MSLKYSNTTADYLEWSEAMNLIRRLTKDKNYKISLLIAIGCFTGLRISDILTLRWKQILGVSEFTITERKTAKQRTIRLNKELQLHIKDCYEHINPLGIAAPVLVSQKGTVFTVQRINVILKELKQRYRLKIKHFSCHSLRKTFGRQVYNMNSDNAELALIKLMELFNHSSVAITKRYLGLRKEEILETYDCLTF
>CP022041|220916:251291|228165_229167_-|ASE18097.1|DBSCAN-SWA
MKAIQIDGYKKGDVKVALRDIEMPKVGDNDLLVKVKAAAVNPLELLIAHGDVKMVVPYHFPLTIGNEMSGVVEQVGASVKDFQVGDRVFGRLPINRIGAFAEYVAVDAAAVAKTPDYLSDIEAAAVPLTALTAEQALDILKLKSGNSLFISGGSGSFGAMAIPLAAARGLKVITSGGAKAKERTMELGVSQYFDYKTEDYTKELKDIDGAIDSLGDKELPRLFSVLREGATLVSLKGMPNGSFAKSFGLPLWKQWLFKLVGMKNEKLASKRNQHYHFIFVTADGAQLRNATAILEARQIRPEIGNVYTLEQAEEALSDVANHRSQGKVIICNS

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ASE18091.1|220916_221261_+|transposase	transposase family protein	NA	NA	NA	NA
ASE18092.1|221376_222246_+|transposase	DDE transposase	NA	NA	NA	NA
ASE18093.1|222731_224462_-	glycosyl hydrolase family 25	Q0SPG7	Clostridium_phage	5.8e-14	33.9
ASE18094.1|224524_224905_+	hypothetical protein	NA	NA	NA	NA
ASE18095.1|225063_227112_+	TonB-dependent receptor	NA	NA	NA	NA
ASE18096.1|227206_227536_+	heavy metal-binding protein	NA	NA	NA	NA
ASE18097.1|228165_229167_-	NADP-dependent oxidoreductase	NA	NA	NA	NA
ASE18098.1|229176_230010_-	alpha/beta hydrolase	NA	NA	NA	NA
ASE18891.1|230016_230373_-	transcriptional regulator	NA	NA	NA	NA
ASE18099.1|230632_231460_-|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
ASE18100.1|231471_232443_-	bifunctional riboflavin kinase/FAD synthetase	A0A1V0SJE1	Klosneuvirus	2.6e-11	34.9
ASE18101.1|233008_234277_+|transposase	transposase	H7BVW5	unidentified_phage	1.5e-67	48.9
ASE18102.1|234407_235283_+	hypothetical protein	NA	NA	NA	NA
ASE18103.1|235480_236044_+	hypothetical protein	NA	NA	NA	NA
ASE18104.1|236094_237903_+	hypothetical protein	NA	NA	NA	NA
ASE18105.1|238665_239688_+	DUF3871 domain-containing protein	NA	NA	NA	NA
ASE18106.1|239768_240041_+	hypothetical protein	NA	NA	NA	NA
ASE18107.1|240067_240517_+	DNA repair protein	NA	NA	NA	NA
ASE18108.1|240516_240720_+	hypothetical protein	NA	NA	NA	NA
ASE18109.1|240833_241421_+|integrase	site-specific integrase	R9ZX86	Cellulophaga_phage	5.4e-20	36.6
ASE18110.1|241903_242110_+	hypothetical protein	NA	NA	NA	NA
ASE18892.1|242162_243152_+	penicillin-binding protein	NA	NA	NA	NA
ASE18111.1|243156_244032_+	hypothetical protein	NA	NA	NA	NA
ASE18112.1|244049_244865_+	hypothetical protein	NA	NA	NA	NA
ASE18113.1|245279_247349_+	hypothetical protein	NA	NA	NA	NA
246311:246325	attL	NA	NA	NA	NA
ASE18114.1|247965_248586_+	hypothetical protein	NA	NA	NA	NA
ASE18115.2|248863_249517_+	HNH endonuclease	A0A2L0V0A9	Agrobacterium_phage	1.5e-18	36.4
ASE18116.1|249702_249963_+	hypothetical protein	NA	NA	NA	NA
ASE18117.1|250067_251291_+|integrase	site-specific integrase	H7BUI8	unidentified_phage	4.4e-32	39.8
256553:256567	attR	NA	NA	NA	NA

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>CP022041|918244:925858|DBSCAN-SWA
CTTATAATGTATGTCCATCAAGATAATCTTGAAGAACTGTCTTATAACTATCTGAGATTGGAAGGATGGAATCTCCGATTACAACGCGGAAACGATCAATGCCATCAATCTTCTTCATGTGCACGATGTAGGAACGATGAATGCGCATGAATTCAGGTTTAGGAAGTGACTCCTCAATCTTCTTCATGTTCATTAGACTCATGATTGGCTTATGGTCGTTAGCAAGATAAATCTTAACATAATCCTTCAATCCTTCAATATAGAGGATGTCATCAAACATGATTTTAACCAGTTTGTACTCGCTCTTCACAAAGATAAAGCGGTCGTTCGACGCATTCTCTGTCTGACGGGTACTTTGGAACCAGTCTAAAGCCCTGTTTGCACCAGCTAAGAAGTCATCATAGCTAATTGGCTTCATAAGATAATCAATTGCATTTGCCTTGTAACCATCGATAGCATATTGGCTGAATGCAGTTGTGAAAATAATCTTAGTTTCCTTTGGTAGAATCTTTGCAAACTCCAGTCCACTAAGTTCAGGCATCTGTATATCTAAGAATATGAGGTCAACCCTATTCTCACGGATGGCTTTTACGCCTTCTACAGCACTATTAAAAACACCAATTAAGTTCAAAAAGAGTGTTTTCTTAGCATAACTCGCAAGCAAGTCTGCTGCTAAAGGTTCGTCGTCAATGATTATACAGTTTAGTGTCATAAATGATAATTTTAGATGAATATGTATTTCTATTACTATCAAATCCCTTCTCCCATTTGTACTTACCAGGGTAAGCAAGCTCAAGACGGCGCTCTACTTGTTTGAGACCTATGCCATGGCCGTTCCTTTCTGCCTCTCCCTTTGGGTTATTACTGTTTTGTATGGAGAATATTATTTGCTCATTATTTGCATCTAACTTTATGTGAATAAAGTTCTTTTGCTCTGGATTAATACCATGTTTAAAGGCATTCTCTAACAATGAGATAAATATCATTGGCGCAACATGGATGTTACAATTAGATGGGATGTTACACTCGCGTTTGATTTCAACATTCTCTGGTATGCGTATCATCATCAAGTCGACATAATTGTGTAAGAACTCTACTTCTTCCTTCAGGCAGACGTAAGGCTGTTGGTTGTCATAGAGAATATGTCGTAACATCTTTGAAAGGTCGATAATTGCCTTCTGCGCCTTTTCTGTATCGAAAGCTGTCAGCGCGTAGATATTATTCATTGTGTTGAGCAAAAAGTGTGGGTTAACTTGCTGACGTAAGTTTACCAACTCGGCTTTTGTCATTGCTGTTTCTGCCTCACGCTTTTCCTTTTCAGCCTTTGACCAACGCTGTGCCATTAGTATCGATGTTGCAACACCAGCACAGATACTTAGGTTAAAGACATTACGTATAATAAAAAAGATGTGTGGGTATACGTACTTGTTCTCTTTGTTTTCTACAAAGATTTGGTATGGATAAGTCATCAGGTTTTGCTCACCTGAGATGTAGTATAACCATTCGTGCTGTACAATAGATAAGAAAAGGATGAGCAGTGTATTGATTACCCAAAACTCTTTCTTCCGTCCCTTTAATAACATGGGGGCAAGTACAAAATAATTGGTATATGCAACTGCCATCATTGAAAGGGGAATGATATATATCGACAAGTCGTTTTGCCATGATGTATGTCCTTGCGGAGCGTACAAAATGGGTATGAGGAAAAGCGGAAGCCAAATGATAATTTGGTTCCAAAAGCTCTTAAATATGTCTGTTTGTTTCCTCATTTATTACTTTTATTTGTCTTTACAACTATATCTGCAAACAAAGGTAATAAAACTTTTTGTAAAATAAAATGTATTGATTGAATATGTGAGTTTTTTTTACATTAACCTATTGTTATATATATACAAAAGGTTTTTAATTAACTTATTTTTATAATAAAACAACCCTAAACAACACTGAAATAGCTTTCTTTACTCTATTTCCTACGTTGTTTAGGGTTGTTAGATACTATGATAATAAATATTTACAATATCTATTTTGTAAAGCTATTTAAGCGTGCTATATATTTGCCAAGAATGTCAAACTCGAGGTTTACAATAGTGCCAATATGAATGTCAGCAAAATTGGTATTCTCTCGTGTGTAAGGAATGATGGCTACCTTAAAGCTGTTATCTGTTGGTTCGCAAACAGTCAGTGAGACACCATTGACCGTAACTGACCCTTTATCAACAGTGAAATAGCCACGTTGTGCCATCTCTCGGTTGCACGGATATTCGAAGGTGAAATAGGTACTACCATCTGCATCTTCCATATTAACACACTTAGCTGTTTGATCAACGTGACCTTGTACGATGTGTCCATCTAATCTACCGTTCATAATCATTGAACGTTCTATATTCACACGATCTCCCACTTTGAGTAAGCCTAAGTTCGAGCGTTCAAGGGTTTCCTTCATGGCTGTCACCGTATAGGTATCGTCTTGGAAGCGAACGACTGTAAGGCACACTCCATTGTGTGCAATACTTTGGTCAATCTTCAATTCCTTTGTAAATGAACATTGAAAAGTGAAATGGATATTCTCCTGTTCATGTTCAATCCCTCTAAGGATTGCCATCTCTTCTACAATTCCTGAGAACATTGCTAAATTTCTTTTATTATCCCCTTTAATAAAGCCTAAATGATGGTATAAGTATTGATAGATAATCTTTTATAACTTCACAGGCTACTTATAGGAGGTTAAGTTTTACATAATTACTATACGTTTGAATAATTGAAAAAGGTGGGGAATCACTTGGAAACCCCACCTCAATCCCTCTTCTTTAAAGAAATGGGAATTAGAAAAGTCGTATCGACGATGTGATGAAAAGTCCGAGTATCAATGATAAGAGAGCTCCTCGTCTTTGTAATCCACTGACCTTGCGGCTTAGTCGCTGAAATGCGATTTATGTGGCCCGCCATTAACAAAAGAAGTCATCTCGGGTTTTCTAATTTATTTGATGACTATCCCGATCGAATCGATACGACTAAATCTGTATCCTTTCTGCGTGCAAAGTTAGCATAAAGATTTTTATCCTCCAAACATTTTATACTTAAAAGTATTTACTTCTGGAGGTGAATCCCTTTGTTCTTTGTGTTGAAAGGAGCAGAAATGATAATGTTCTTTTGTGTATAACTTTAATAGTTTATTGGTTTTATAACCTTCTTTTGATAACAATTTGCCCTCGTCATGAATACATATTTGCAGGTGTTTATCGCTCCGCACCATTGGTGCTAAGCATCAACACGACATGTGCTAAGCCTCCGCACCATACGTGCTAAATATTGACACGTTGATAAAATGAGGGAAGAAAGGCTCATTATTGTCATTTTAGAGAATGATACTAATATCCCTATTTTTAGAGAAGAGCATCTTGTAGAATTTCACTTAACGTTGGATGGATATGAATGATGTCTCGTATCTTATCCAGTTTAGCATCATAATTCATTAAAGCTGCAACTTCTTGAATAAGGTCGGCAGAGTGAGCACCATAGCAGTGTGCACCTAATATAGAGCCATCTTCAGCTATAAGCACCTTTATCATACCTTCAGTTTCTTCCATGCTTAAAGCCTTACCATTGGCACGATAGAAACCTTTTCGAGTAGAGTACTTGATTTCCTCAGCTTTACACTGGTCTTCAGTCTTACCTACGCAGGCTGCTTCTGGATATGTAAAAATCGCAGATGGCATGATATCAAGGCGGATGTTATCGTCCTTTCCAAGAATATGATTGACAGCACGGAAGCCTTGGAAGGTTGCTGCATGCGCTAACATTTGGCGTGCATTGACGTCACCGATAGCATATACACCCTTCACATTTGTTTCCATATTGTCATTGACGACAATACCCTTTGCGTTTACTTCTATACCAGTCGATTCAATACCGATATTGTCGAAGTTGGCTTGACGACCAGTAGCAATCAATACAAGGTCGGTATCAATTCTATCTTCTTTACCCTTTTTATCGAATATAACGGTTGTATACTCTTGTCCACTCTCAGCAGGTGATAGGATTTGTTTTACGGCACTCTGCATGTAGAAGGTCACACCTCTTTTCTCTAATGTCTTCCTTAAGCGTTTAGCTATATCGCTGTCAATAGGAGGGAGGCATTCCTTCATAAACTCGATAACTGTTACTTCACTACCGAAAGCTGAGAAAGCTGAGGCAAATTCCATTCCGATAACTCCTGCCCCAATGATTGTGAGGCGTTGAGGAACCTTCGCAATAGAAAGTAATTCCGTGGATGTGACAATGTTTTGTGCTGTTTCAGACTGGCTCAAGAAGTCTTCTTCACTCATGAAAGGTGGCATCTTTGAACGTGAACCAGTCGCAATGATGATATGCTCAGCCTCTATTTGTTCGCCATTTACTTCAACAACATGGTCAGAAACAAAACGAGCCTCACCTATAATAAAGTCTATACCAGGCTGACTAAGTAAAGTGCTTACGCCCTCTCTAAGTTGATTGATAACTCCTTCTTTCCTCTCCATTACCTTCGCAAAATCGAGTGGGGGAGTCGTTTCGTAAAGAGAAGAAGTCGTAAGGCGTAGCTCAGCATCATGTGCAAGGCATTTCGTAGGAATACAACCAGCATTCAGACAGGTTCCACCAGGCTGTGCTTTCTCAATGATTGTCACTTCCAAACCATTCTGAGCAGCATAGGAAGCGGTTCGGTAACCACCAGGTCCCGAACCGATTATTAATAGATTTGTCTTTTTCATATTCAATCTCTTATAGAGTTACTGTGGAGATACGCTATGCATTCTCCTCTACGTCGTTGACAAGCTGACGATAAGTAAGGATTGGATGCTTAGCTGCAAGAACATCATCTACACGTCCAATAGGTGTGTTGTATGGTGCTCCCTTAACAAGCTCTGGGTTCTCAAGAGCCTCTTTAGCAATGGTATGCATCACCTCTATAAATCCATCAATAGTGTCCTTACTTTCTGTTTCTGTTGGTTCAATCATCATAGCCTCATGGAACAGAAGTGGGAAATATATTGTTGGAGCATGATAGCCATAATCGAGTAGGCGTTTGGCAACATCCATTGTTGTTACACCGGTACTCTTATCTTTCAAGCCATCGAATACAAACTCGTGTTTACAAAGTGTGTCAATAGGAAGCTCGTAATCATCCTTTAGACATTCCTTGATATAGTTCGCATTTAGAGTTGCAAATGGTCCAACCTCCTTGAGATGCTTCTTGCCAAGTGTGAGAATATAAGTGTAGGCACGTAGAATAACGAGGAAATTGCCGAGGTAGCCACTAATACGAATATTATCAGATGAGAATTCTCCTGTCGTATCTGGATTGTCAATAACAAAACCATCCTTCGTCTTCTTTACATGTGGCTTTGGTAGGAATGGAATTAGTTTCTCACCGACACCGACAGGACCAGCACCAGGACCGCCTCCACCATGTGGTGTAGAGAATGTCTTGTGTAGATTGAGGTGAATAACATCGAATCCCATGTCTCCAGGACGTGCTGCACCTAATAGTGGATTGAGGTTGGCACCATCATAGTACAGCAGACCGCCACAGTCATGTATGAGCTTAGCAATCTCTGGAATATCTTTCTCAAAGAGACCTAAGGTGTTAGGATTGGTCATCATCATACCTGCAATGTCATCACCCAAGAGCGGTTTTAAGTCGTTGACATCAACAAGTCCCTCAGCTGTACTCTTTACTTCTACAATCTCTAAACCGCAAACAGCAGCAGAGGCAGGGTTAGTACCATGAGCAGAGTCAGGTACGATAACCTTTGTTCGCTTTGTGTCACCACGCTGTTGATGGTAAGATGCTATGAGCATCAAACCTGTTAACTCGCCATGTGCACCAGCGTATGGGTTAAGCGTGACTTCTGCCATACCCGTAATAGAAGCAAGAGCACGTTGAATATTGTATTCAACCTCCAATGCACCTTGGACTGTTTCAATAGGTTGGTGAGGGTGAAGGGCTGTAAAGCATGGCATTGAAGCTATCTCTTCGTTGATGACCGGATTGTACTTCATCGTACAAGAACCCAGAGGATAGAAACCGTTATCAACGCCAAAGTTATTTTCACTATGATTAGTATAATGACGTACAACCGTCAACTCATCACATTCTGGTAGCTCTGCATCTTTCTCTCGTTTGCAGAAGTCGGGTAAAGGATGATGGCCAAAACGATTCTCAGGGAGGCTGTAAGCACGTCTTCCTGGATGTGACAACTCAAATATCAAATTGCCATATAGTTTATTATTCATTGTTGCGTAGATTTAGAAAAACTTTGTGTGACTATAATAATCCGACGAGTGTATCAATCTCCTCTTTTGTACGTTTCTCTGTAACGGCAATAAGGAGTTTGTCATCATCAACCTTGATACCTGGGAGAATACCCTGTTTGATAGCCTTGTCGAAGAAGGTATCGCGTTCCTTTATTTGAATAAGGAACTCATTAAAGAAAGGCTTGTTGTGAACAAGCTTAACTTTACCTGTACTAAGGAGTTGCTCGCAAAGGTAATGTGCACCATCATAGCCCATCTGAGCAGCCTCTTTTATACCCTCTTTTCCCATCATACTCATGTAGATTGTAGCATAAAGCGCCATCAAACTCTGGTTAGAACAGATGTTTGAAGTTGCTTTCTGACGACGGATATGCTGTTCACGTGCTTGTAGTGTCAGTGCGAATACACGCTGTCCACGGCTATCGCATGTCTTACCAACGATACGACCTGGGAGTTTTCGCATTAGCTTTTCAGTTGAACACATGTAGCCAGCGTATGGTCCACCAAATGCCATTGGAAGTCCAAGACTCTGAATATCGCCTATAGCAATGTCTGCACCCCATTCTCCTGGTGTCTTTAATAAAGCAAGGTCAGCTGCAACACTGTTAATAATGAACAGTGCCTTTTCTTCATGGCAAGTATCAGCAAAGCCTGTAAAGTCTTCAATAATACCATGTCGATTAGGCTGTTGTACAATAACTCCAGCCACACCACCTGCCTGTAATTGGTTTTTTAAGTCTTCGTGTGAAGTCTCTCCATCAACCGCCTTGATTGCCTTGAGCTTAATGCCATGAAAATGTGCGTAAGTCTTTAATACGCCAATGATATTCTTGCATAAAGTCTCAGAATATAATACAGTGTCAGCCTTCTTTGCATTATCAAAAGCCACCATCATAGCTTCAGCAGTTGCTGTAGTGCCTTCATACATAGAAGCGTTGGCGATATCCATGCCAGTAAGTTCAGCCATCATACTTTGGAACTCAAAGATATAATGGAGTGTTCCTTGTGATATTTCAGCTTGATAGGGGGTATATGATGTAAGAAACTCCGAACGACTGAGAAGATTCTGAATAACACTTGGCGCATAGTGGTCATATACACCTCCACCTGCGAAGCAAGTAAGCTTGTCATTCTTTTGTCCAAGTTTCTCAAAGAAAGCGCGTATTTCTAACTCGCTCATCGTCTCAGGAATATCATAATCTCCCTTGAAACGGATGCTCTCAGGTACTTCAGCATATAGGTCTTCAAGCTTCTTTATGCCAATACGGTCAAGCATCTGTCGTATATCCTCACCTGTGTGAGGTAAAAACTTATGAATCAT

Protein sequences of DBSCAN-SWA_2

>CP022041|918244:925858|924547_925858_-|ASE18576.1|DBSCAN-SWA
MIHKFLPHTGEDIRQMLDRIGIKKLEDLYAEVPESIRFKGDYDIPETMSELEIRAFFEKLGQKNDKLTCFAGGGVYDHYAPSVIQNLLSRSEFLTSYTPYQAEISQGTLHYIFEFQSMMAELTGMDIANASMYEGTTATAEAMMVAFDNAKKADTVLYSETLCKNIIGVLKTYAHFHGIKLKAIKAVDGETSHEDLKNQLQAGGVAGVIVQQPNRHGIIEDFTGFADTCHEEKALFIINSVAADLALLKTPGEWGADIAIGDIQSLGLPMAFGGPYAGYMCSTEKLMRKLPGRIVGKTCDSRGQRVFALTLQAREQHIRRQKATSNICSNQSLMALYATIYMSMMGKEGIKEAAQMGYDGAHYLCEQLLSTGKVKLVHNKPFFNEFLIQIKERDTFFDKAIKQGILPGIKVDDDKLLIAVTEKRTKEEIDTLVGLL
>CP022041|918244:925858|920263_920869_-|ASE18573.1|DBSCAN-SWA
MFSGIVEEMAILRGIEHEQENIHFTFQCSFTKELKIDQSIAHNGVCLTVVRFQDDTYTVTAMKETLERSNLGLLKVGDRVNIERSMIMNGRLDGHIVQGHVDQTAKCVNMEDADGSTYFTFEYPCNREMAQRGYFTVDKGSVTVNGVSLTVCEPTDNSFKVAIIPYTRENTNFADIHIGTIVNLEFDILGKYIARLNSFTK
>CP022041|918244:925858|921626_922991_-|ASE18574.1|DBSCAN-SWA
MKKTNLLIIGSGPGGYRTASYAAQNGLEVTIIEKAQPGGTCLNAGCIPTKCLAHDAELRLTTSSLYETTPPLDFAKVMERKEGVINQLREGVSTLLSQPGIDFIIGEARFVSDHVVEVNGEQIEAEHIIIATGSRSKMPPFMSEEDFLSQSETAQNIVTSTELLSIAKVPQRLTIIGAGVIGMEFASAFSAFGSEVTVIEFMKECLPPIDSDIAKRLRKTLEKRGVTFYMQSAVKQILSPAESGQEYTTVIFDKKGKEDRIDTDLVLIATGRQANFDNIGIESTGIEVNAKGIVVNDNMETNVKGVYAIGDVNARQMLAHAATFQGFRAVNHILGKDDNIRLDIMPSAIFTYPEAACVGKTEDQCKAEEIKYSTRKGFYRANGKALSMEETEGMIKVLIAEDGSILGAHCYGAHSADLIQEVAALMNYDAKLDKIRDIIHIHPTLSEILQDALL
>CP022041|918244:925858|918929_920012_-|ASE18572.1|DBSCAN-SWA
MRKQTDIFKSFWNQIIIWLPLFLIPILYAPQGHTSWQNDLSIYIIPLSMMAVAYTNYFVLAPMLLKGRKKEFWVINTLLILFLSIVQHEWLYYISGEQNLMTYPYQIFVENKENKYVYPHIFFIIRNVFNLSICAGVATSILMAQRWSKAEKEKREAETAMTKAELVNLRQQVNPHFLLNTMNNIYALTAFDTEKAQKAIIDLSKMLRHILYDNQQPYVCLKEEVEFLHNYVDLMMIRIPENVEIKRECNIPSNCNIHVAPMIFISLLENAFKHGINPEQKNFIHIKLDANNEQIIFSIQNSNNPKGEAERNGHGIGLKQVERRLELAYPGKYKWEKGFDSNRNTYSSKIIIYDTKLYNH
>CP022041|918244:925858|918244_918955_-|ASE18571.1|DBSCAN-SWA
MTLNCIIIDDEPLAADLLASYAKKTLFLNLIGVFNSAVEGVKAIRENRVDLIFLDIQMPELSGLEFAKILPKETKIIFTTAFSQYAIDGYKANAIDYLMKPISYDDFLAGANRALDWFQSTRQTENASNDRFIFVKSEYKLVKIMFDDILYIEGLKDYVKIYLANDHKPIMSLMNMKKIEESLPKPEFMRIHRSYIVHMKKIDGIDRFRVVIGDSILPISDSYKTVLQDYLDGHTL
>CP022041|918244:925858|923025_924516_-|ASE18575.1|DBSCAN-SWA
MNNKLYGNLIFELSHPGRRAYSLPENRFGHHPLPDFCKREKDAELPECDELTVVRHYTNHSENNFGVDNGFYPLGSCTMKYNPVINEEIASMPCFTALHPHQPIETVQGALEVEYNIQRALASITGMAEVTLNPYAGAHGELTGLMLIASYHQQRGDTKRTKVIVPDSAHGTNPASAAVCGLEIVEVKSTAEGLVDVNDLKPLLGDDIAGMMMTNPNTLGLFEKDIPEIAKLIHDCGGLLYYDGANLNPLLGAARPGDMGFDVIHLNLHKTFSTPHGGGGPGAGPVGVGEKLIPFLPKPHVKKTKDGFVIDNPDTTGEFSSDNIRISGYLGNFLVILRAYTYILTLGKKHLKEVGPFATLNANYIKECLKDDYELPIDTLCKHEFVFDGLKDKSTGVTTMDVAKRLLDYGYHAPTIYFPLLFHEAMMIEPTETESKDTIDGFIEVMHTIAKEALENPELVKGAPYNTPIGRVDDVLAAKHPILTYRQLVNDVEENA

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ASE18571.1|918244_918955_-	DNA-binding response regulator	A0A2R2ZGH8	Clostridioides_phage	7.2e-19	30.3
ASE18572.1|918929_920012_-	sensor histidine kinase	Q9EYF3	Enterobacteria_phage	1.1e-07	25.2
ASE18573.1|920263_920869_-	riboflavin synthase	A0A2I2L4R9	Orpheovirus	1.6e-22	35.9
ASE18574.1|921626_922991_-	dihydrolipoyl dehydrogenase	A0A2K5B2C5	Erysipelothrix_phage	2.3e-53	33.5
ASE18575.1|923025_924516_-	glycine dehydrogenase (aminomethyl-transferring)	M4QFZ1	Prochlorococcus_phage	2.8e-81	39.2
ASE18576.1|924547_925858_-	aminomethyl-transferring glycine dehydrogenase subunit GcvPA	E3ST28	Prochlorococcus_phage	2.6e-59	37.3

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>CP022041|1279773:1354453|DBSCAN-SWA
CTTAAGCACACAATTTCATAAGCCTATATAAAAAGAAAGGAATATCTGTGACTCCTCTGAACTGCGCCCTGAATGCCTTAACCTTAGCATTGAATGACTCGGCATTTGCATTCGTAGCTCTGTTTACAAAGAAATTGAGTATGGTTTGATAATGATTTTCAAACGTGTCAATCACTGTGTAGAAATTGTCCACTCCCAACTCTTCAACTTCATTAAACCATTTTGCCAACTTCAGCCTTGCAGCATCCTTGATGCTCTTGATGTTATAAATATCGGTAAGTTTCATAGCCAAATCATATGCCTTTTTCAGTGTCGGATAATGTTCAAAGATGATTTCTGCCCTACCTTTCTGTGTTTCAGTCCACTTGGTCTTGTGCTTGGTCAATATGAACTTTGCTCTGGCAAGCAACTGCTTACGCGTGTCACCATTGCTGTATCTAAATGGTATATATTCCTTACCCTTACATTTAGCTTCTTTTATCTCCTCATTCTCTTTATCTCTTGCCATCCATCGGTAAGCGATACGCATGTCATCCAGAGCATCATAATATAGTTTCTGCACATGAAATCTATCATTGGTAATAAGTGCTTTGGGAAAAACAGCACGGGCTATGCGCATCATAGAAGATGATAAGTCGAGTGTTATCTCCTTGACAGTCTTTCGTTTAGAAAGGTTTATCTTCTTGAGAATCTGGATGACGTCCTCTGCCTTGGTCCCTTTAACCACAGCTACCAAAGTCCCTTCTCTGCCCTTTCCTGCCTTGTTGGTCAGAAAAGTATAAACCTCGCCACAGCTTAGACAGGTCTCATCAATACTTAGACTCTCTCCTATGTTATCTTCAAACAATAGCCAGTCTTGAGCATGATCCAACTGATCCCAGCTACGGTAATCACTGAAATGTTCCTTGTACTGTGTGGATAACAGCTTGCCATTTACGCCATAGTGCGAACCAATGCTTGCGATGCTCTCTGCAGTGGACTCAATTCTATTCTTTTAAAAAAGAAACGAACTCGGGAGATAGTCTACTACCCTCAGCCGTCAAATCATCATATGAATAAGTAAATATCTCTCCGTTGGAACTGTCACGCCACTTGCGACGACGAACATGGCGGTAAACTGCTTTGCCACGAAGGGGGAAGTCCTGAATAACACGCTCGCTGGTAAAACCATAACTGCTTACAGTGCCTAACTTATGATCTGACTTTTCCATAAAGTTACGCTCGTCAAGCCAAAAGTCAATCTGCGAAACACTCTCTTGAATATCGACAACATCAAAGTAGTCAGCAAGTACATCTGGAAAGATGCAACGTAATAATTGGTGATTCTTCATGATGCAAAGGTAATAAATACTTATGAAATTATGTGCTTAAGAGTATAGGCTTGCAACTGGGTTTTAGGACTGACCCCAATTAACCACCTTTTAAAATCCTTATTCACAACTATCTGATAGTAAACAACTTACAAATGCACTAAAATAATTCACTTTCATGCTATTTTTCCACCTTTTCTTCGAATATTTTGTCAATATATTTCCTTGCCTTTTTAAAGTAAATATCACACGAAGTCACGGAGATAAAAGCGTATTAATTTAAAGATACGTAATCACAGAGGCACCAATAGTGTAAGAAGTAAAGGAATATAACAACAATATTTATTGAGAAGAATACGCCATCAACCCTTAGTTAGCAATGTAAACACATTATATAATCTGATGATATATCAATCTTTATAACATTTTTTATTAATTCCTATTACGTAAAAAGACGAATTAGGTTGTTATAAGAAGTGAGTAGCAGGAAAACTGCTGACTAAAATATTAAAATACAATACGCCTCAGTTGAAACAAAACAGAATGAGTGAAATAAATAACAAGACCATTAAAGACTATCTTATTGGCAAAGCAACAGCCAAGGAGATGGAGCAGCTGGCTGAATGGCTGGCGGTCTCGGAGGAAAACCAAAAGGAATTCTTCGAGATGGAGTTGGCTTTCCATTTAGGAAAGAACAACTCGTTGGTTACATCTAAGAAAATTGAAGAAGCAGAGACTAAACTATTTGACCAAATCACTGAATACGAAGAACAGAACAGAAATAAGAATAAACTTTATTTCCTCCGCTATGCTGCAGCAATTATTGTTGCCGTATTACTGATTGGAGGAGGACTCTTTGCATATCTTCACCAGTCTGCAGAAACTATCACTGTTGCAGCGATGAACGAGGTAAAGAAAGTCGTTTTACCTGATAATTCTACCGTTTGGCTCAACAAGGGAGCTACAATTAGTTATGCAGGTAACTTTGAGGGCGACGAGCGTAAGGTAAACTTAAAGGGCGAAGCATTGTTCCACGTAACAAAAAATGCTGAAAAACCATTCATTGTAAACAGTGATGGAGCATCAGCAAAGGTATTGGGAACAACCTTCAACTTTAAAGATCAAGCTGCTGATGGAAAAGAAGTTATCAGCTTGATAGAAGGTAGATTGGAAGTAACAGGACTGAATGGAGAAGGAAAGGTTGTCCTTCATCCCAACCAAAAGGCTACTGTCAGCAAGGATTCCAAGACCATTAAGACAGAAAATAGTTATGCACTTGCCGACGCTGTATGGCGTGACGACATAATCCCATTTAACAATATGCGAATCAATGAGATTGCTAAAATCCTTGAGCAGCTCTACGATTACAAGATTATTGTTGACGCTAAGTTAGACCACACAAAAACTTACACAGGTGTTATCAAGAGAAACAAGGATATAAGAAATGTCTTAGACGGACTTTCTTATACCATCTCTTTCCACTACAACATTCACGACAAAGAGATAACCCTCTCAGAATAAGTATCTGAGAGAGCTATCTTTTTGCCACGAAACGTCTAAATCAGTTTCTTAAATTTTCATTACCTAACATAGACATGAGAAAACTTTACGCGCTTCTTATAGGAGCACTCGCCCCTTTATGTTCGTATGCTCAGACCACTTTCCCTGAGTGGCAGAGTCAGTACACCACTGGTTTGAACAAGATTGAGCCACATGCCTACGTCCTTCCTTATAGCTCGGTTGATAAGTTACAACAACCAGGTGGCTATGAACAGTCAGATTATTATATGTCGCTCAATGGCAAATGGAAATTCCATTGGACTAAGAATCCAGATAATAGACCAAAGGATTTCTTCCAAAACGACTTTGCTGTGCAGGGTTGGAATGACATCAACGTACCAGGTAACTGGGAGCGTCAGGGCTATGGGCTGCCTATCTATGTAAACGAAACATACGAATTTGATGACAAACTCTTCCAATTTAAGAAGAATCCTCCCCTCGTTCCATATGCACAGAACGAAGTTGGCTCTTATCGTCGCACCTTTAAGATTCCTTCAACATGGAAGGGTCGTCGTGTAGTTCTTTGTTGCGAGGGTGTTAAGTCATTCTTCTATCTTTGGATAAACGGCACTTACGTTGGTTATAACATGGGTGCTAAGATGCCTTCAGAGTGGGATATTACAAAGTATCTGAACGATGGTGAGAACACTATCGCTATGGAAGTCTATCGTTGGGCATCAGGTTCTTACCTTGAGTGTCAGGACTATTGGCGCATAAGTGGTATCGAGCAGGACGTTTACCTCTACTCTACTCCAACACAATATATCGCTGATTACAATGTAGCAGCAGGTGTTGACAAGCAGGACAACGGCTCTTTCAATGGTAATTTTAGCCTTACTACAAATATTAAAGGTGCAGGAAGCGGTAGTGTAAGCTATGTTCTAACCGACGAAAAGGGCAATACTATCCTCTCAGAAGATAAGGCTGTCAGCGCAAAGAACAATGATGAAATGGTGAATTTCACCACAAAGACCATCCAGAACGTTGCTGCTTGGAGTGCTGAACATCCTAACCTCTATACCCTTCTTATCACTTTAAAAGACAAGAATGGTAATGTTACCGAACAAACTGGTAGTAAGGTAGGATTCAGAACAATTGAAATTAAGAACAAACAGCTCTGCGTGAACGGAACACCTATCCTCGTAAAGGGTGCCAACAGACATGAGCATTCAGAGTTAGGACGCACCGTGAGCAAGGAACTCATGGAACAGGATATCCGCTTAATGAAGCAGAATAACATCAATCTTGTACGTTGTTCTCACTATCCTAACGACTCTTATTGGTACCAACTTTGCGATAAATACGGCTTGTATGTTATCGATGAGGCAAATATTGAGTCTCACGGAATGGGTTATGGCAAGGAGTCTTTGGCAAAGGATAGCACATGGCTGACTGCTCATATGGACAGAACGCGTCGTATGTATGAGCGTTCAAAGAACCACCCAAGTATCATCATCTGGTCATTGGGTAATGAGGCGGGTAATGGTGTGAACTTTGAACACACCTACCGGTGGTTGAAGAATGCTGACAAGACACGTCTTATCCAGTATGAACGTGCTGAGGAGAATTTCAACACAGACATCTATTGTCCTATGTATCAGTCGCTCGACCACATGAAGGCATATGCAAAACGTACCGACATAACACGTCCTTACATCATGTGTGAGTATCTTCATGCTATGGGTAACAGTTGTGGTGGCATGAAAGACTACTGGGATTTGATCGAGTCAGAGCCTATCTTGCAAGGTGGTAGCATATGGGACTGGGTGGATCAGTCTTTCCGTGAGCTTGACAAGAATGGTAACTGGTATTGGAGTTACGGTGGTGACTACGGTCCAAAGGATGTACCAAGCTTCGATAACTTCTGTACAAACGGACTCATCGCTGCTGACCGCACTCCTCATCCACACCTTTCTGAGGTGAAGAAAATCTATCAGAACATCAAGTCTGAGCTCGTTTCAAACGAGAAGGGCATTACAATAAAGGTAAAGAACTGGTTTGATTTCACCGATCTGAATGCTTACCAGCTCAACTGGCAGATTGTTAATGAGAACGGAAAAGTTATTGCGAAGGGAACACAACACGTAGATTGTGCTCCACATGAGACAACAACAATCACACTCCCTGCTGTTTCTGCAACTACAGATAAGGAGCAGTACCTCAACCTTGAGTGGTATCCTGCTAATGATGCATTGATTCTTACAAAGAATGATGTTGTAGCATACGACCAGTTTGTACTGAAGAAAGCAAGCGATTGCACGACCTTCCTCCCACGTGAGAAGCAACGCATGACGTATAAGGTGAACGAGAACACAGGTGAGTTGACCTCGCTGAAGAGTGGCAACCAGGAGTTCCTCGAAGCGCCACTGAGCCTAAGTTTCTACCGCCCAGCTACCGACAACGATGGTCGTGACCAGTTCGGTGTAAGAGTATGGCGCAAGGATGGTATCGATTCTATCAGTCAGAAGGTTACAAAGATTACCCGTACTAAGGACGTGACACGTGCAGAAGCCGACATTATCGGTAAGAAGGGCAATGTAATCGGTAAGGCTGTCTTCACCTATCAGCCACAGAAGAATGGCGCATTGGCAGTGAAGGTTGATTTTACTCCAGACACAGCAGCTGTCAAGGCACTCGCACGTCTGGGGCTTACCTTCTGCGTAAAGGATACATTCGGCAAGGTTGAATACAATGGTCGTGGTGATATTGAGACTTACAACGACCGTAAAGCCGCTGGTTTTATTGGACACTACAAGACAACTGCAGAGGCTATGTTCCATTATTATGTGAAGCCACAGGCAACGGGTAACCGCACGGATGTACGTTGGGTATCAATCTCTGACACACGTAATCGCCTTATGGTTGCTGCAAAGAGTCCATTCCAGTTCTCTGTAACTCCTTTCTCTGACAGCGTTATCGACCGTGCGACGCATATCAACCAGCTCTCACGTGACGGTCTGCTTACCGTACACTTAGATACCAATCAGAGTGGTGTTGGTACCGCTACTTGTGGTCCTGGTGTTGCTGAGAAGTATCGTGTATCTGTTAAGCCAACAAGCTTCGAGTTTGTACTCTACCCTGCTATGGCTAAATAAATAGCACATAGTAAGAAGCTATAACAAAGCCCTGTTCCCTTTGCTTACAATCAGTAAGGCAGAAAGGAACAGGGCTTTTTGCGCTCTATAGACTTCAACTTGAAACGCAATTAGCGGTCAGCACCATTGGTGCTTACCATCCGCACGACATGTGTTAGGCATCAACACATCAGCTAAAGATAGCAAGAAAGGAATATTAAGGTCGTTATAACAAAGAATGTAAGATGCTAACCTCTAACAAAAAAGAGAGAAGTTAACCAGATAACACTTATAAAGAAATAATTATTTACGTAAAAAAGAAACATCTATTTTCACGTAAATAATTATAAACCGACCAGCTAAAGAATATGTGAACCAGTCAAAGCCCAGTAAGCAACACCAAGAACTACCGCTGCAATGATAATACGGAAGATGCAACCAGTTATCTTCTTAATGAGATAGATACCGATAACCAAGACAGCAAGTAAGCCGATAAAATATTGTAAATTCTCCATTGGGTATTATTTGATTACTTAAATAAATGTCTGAACACTTGAGGCACTGGCGTCTCGAACTCCATACGCTGATGTGTAACAGGATGATGAAAACAGAGTACGTATGCATGTAGACAAAGACGATGAAGTGGATCATCACCATTACCATACTTTATGTCACCGCAAACAGGATGTCCCATATCGGCAGAATGTACACGAATCTGATTCTTACGACCTGTCTCTAACTGATACTCAACAAGGCTGTGCGCTACCGTACGATCAAGTACATGGAAATGTGTAACGGCATATTTTCCACCATTATCTACTGGCGAACTATAGGTTACGTATGACTTATTATCCTTTAGCCAATTGGCAATCGTACCTTCATCATGCTCCATCTCACCACTGACTACAGCCACATAACGACGGTCATAAACGATATTATGCCAGTCATGTTCAAGTAACTGCTCCGTCTGTATGTCCTTAGCATAAATCATCAGTCCTGATGTATCACGGTCAAGTCGATGGACAACATGTGCCGTACACTTCTGCTTTGTCTTACGGAAATAATCGTCAAGAACAGTCTTCACATTCAATGAAGAATGCCCAGCAGCCATTGAAAGAATACCAATATTCTTTTCAATCACTACCAAAAATCTGTCTTCATAGACGATCTTCACATAGCGACTACGGAAGAGATCGTTCTTCTTGCTCTTGCTAACAGATATCTTGTCGCCAGCCTTCAGTGGATGGTCAAACTGTGTAACGCACTTACCATTCACCTTGATACCACGATTCTGTAGCGTTGCCTTAACCTTACTCTTACTCTCATTTAGGTTAGCCAGCAACCATTCAAGCAACGGAGCGGGGGCCGTCACCTTATAATGCTTATATTTTTCTTCTGTATATGGGTTCTTTCTTATCATACTACAAAAGTACAAAGAAATAATGATTTAAACTATTACACGCCTAATAAATCATCCGAATGACCTACGACAGAGATAAAACAGCTAATATATTGCTTTCCTATAATAAGGTTGTCAATACGCTCAATACCGTTTTAGAACATCTTAACCCACTCACGAAAGCGTGCAACACCTTCTTCGCCAAACTTGGAAAGACTTGCTATTGCCTGCTCAATCGTCTTCTCTTCATCAAGATGAGACTTAGAAAAAAACTTATCAGCATAACAAATTACCTTCTCTTCCATGGTTTCAGGGAGGAAGTCTTGCTGAGGAAGTGGCAGCTTTTGTGCAATGATTTGGCTACGAGTGATACCCGCTCCTGTATGACGTTCACAAACGCGAGCATGTCGAGGGAAGCCTTCTGCACGCAACATCTCTGCACCAATACGACCATGACAGATATAAGGCTCAGTGCCGAAACATTGTATACCTGGGGCATTGCAACGAACAATACCTATATCATGCAGCATAGCAGCTTCCTCTATAAACTGACGGTCAAGCGATAACTCTGGATGACGATCAGCAATAGCAAGTGCTTTATCCGCTACAGCACGACTGTGAACAAGAAGGATATGACGTAGTTCGTTATCCTCGGGATAGTATTTATTGATAATTACTTGGTAATCCATATCACGAAAAAAGCCACACCTCCTCTCCCAGTCGGCTTACACCGCCATGAATGAGGAGCCGTGGCCCTATCATTTGTAATAATGATTCTTTATTCTTCGTGTGCTCTCTCGATGTAAGCGATAACGTCGCCCTTGTCTACCTTAGCACCCTGCTTAGCGTTGATTTCCACTAACTTACCACCAAGGGCAGCAGGAACAGTTACAAACTCACCCCAAGGAGCCTGAACGTAGCAGAACACATCACCTTCTTTATACTCCTTACCGATGAATGGTTCGATAGCTGGAGCAGCCTCACCATCACCCTGGAATTCCCAGAAGAGCTGACCCTTAACAGGAGAAACAATAGCATCAGCCTTAGCATGCTTGAATGCTGCTGCCTCCTCTGGGCTTACCTTTGCACCGAGTTTAGCATCCTTTGCAGCCTGAAGGTCAGCAAGGAAGTTCTTCTTAGCCTGTCCGCTCTTGTAGTTACGATACTGCTCTGGGTGCATAGCCAACTCGAAGAGTTCCTCATCATCCTGTCCATAATCCCATCCGTTCTCATCCATTTCCTTACGGAAGTCGTCAAGAGCGTTTGCAAGTAAGGTGTGAGGATCGGCATCAGTGAACTCAAGACCTTTCTGCTTAGCAAGGTCTTTCAACTCCTGACATATCTCACCAGGAACACGACCACTCTTACCAAGAATCATACCCCACATAGAATCGTCCATCATTACGAAGCGACCCTTACCCTGCTCAAGGGTGAGGAGGTTCATAAGAGCAATGTTCTTTGTGTATTGTGAGAATGGAGTTACCAATGGAGGATAACCTACGCGTGGCCATACATATGCCACCTCATCGAACAACTTAACGAGCATATCATCTACAGAAAGCTCTGGTTCGCCCTTCTTCTTGCGGAGGTTATTGATAGTTGAACGAATACCACCAAGATCAGCCATCATAGAACCCATCATACCACCTGGCAAACCACACTCAAGAAGCAATGAACTCATAATCTTGTTCTGTGGGTTGATGAAGTAGCCGAGCCACTCATCAATAAACTCCTGAGTCATAGCACGTGCCTTCATGTAGGCATCCATGTTGATTTCTGGTACATCAAAGCCAGCGTTCTTCAACATGCTCTGTACAGAGATCACGTCTGGGTGAACCTTACCCCATGACAATGGCTCAATAGCAACATCAAGAATATCAATACCATTCTTGGCTACCTCAAGCATAGAAGCCATTGACAAACCTGGACCAGAGTGACCGTGATATTCAAGAATAATGTCTGGATGTTTCTCCTTAATGCGACGAGTCAACTCACCAAGGAATGCAGGCTGACCGATACCAGCCATATCCTTCAAACAAAGTTCCTCTGCACCAGCTGCAATTTCCTCATCAGCCAACTTACAGTAGTACTCAATTGTATGAACAGGAGAGGTAGTGATACAGAGTGTTCCCTGTGGAGTCATACCAGCTTCCTTAGCCCACTTCAATGCAGGCGCAATATTACGAATGTCATTCAGACCGTCGAAAAGACGAGTGATATCCACACCCTGAGCATGCTTTACACGATACATCAATGCACGAACATCATCAGGAACAGGATACATACGCAAAGCGTTCAGACCGCGGTCAAGCATGTGCGTCTTGATACCAGCTTCATGCAGAATCTTGGTGTAGGCACGTACAGACTCGTTTGGGTTCTCACCAGCTAAAAGATTAACCTGTTCAAATGCACCACCATTGGTTTCTACACGTGCAAAACAGCCCATCTCAACGAAGACTGGTGCGATACGAACTAACTCATCCTTACGTGGCTGGAACTTACCAGAGCTCTGCCACATGTCTCGATAAATGAGACTGAACTCAATTTTCTTTCCCATATATATTTTCAATATGTTACTAAATGAAGGGATTGCAGCATGCAATCTGACCTGCAAAATTAGATAAAAATTTCCAAAAAACGACTGACCGCTAATATTTTTTGCAATAATTGACTATCTTTGCAGTCTAAAAGTTAGTACATGAAGAAAATGTTTTTCCCTCTCTTCGGCTTTGCACTGCTTTTCCTTACAGCTTGTTACAACCAAGTATCGACTGGAGATCACAGTGCTATCGATGTTGAGGTTCAAATGAAAGGTGATAGTACACGCTACGGATTGGCGTGCGACGGTTGCTCTGATTCTATAATTGTTCTCCTACCAAATGAGGGAGGTGACCCTGTAAAGTTTGACATTGTAACAGCAAAACGCAATGGCATGGTTTATGGTACACCCGAGATAGGTGACGAATTAGCAATTGTTCCTAATCCTATTGACCCTTACGAGGCGGAAATGGTTATTAATCTTGAACAAATGAAAGGTACATGGACTTTCCAAGTCTTGCCAAAGTTAAAGCCTAACCCTACGAAGACAGAGGAGGAAATATTGGCTGGCATGAGCGATTCTATGAAGGCTGCCTTGTTTACACCGCGTGAGTATGGCTTTACACTGAAGAGTTATAACCAAGCTTCGCCAGTGGGTTATGTCATGAAAGCTAACTCTTTGGAAGATGAAAGTCCTGTGGAATATCCTAAGGTGACTGTCTATACGAGCTGGCACATCTTCAACGGTAGACTTTATATCTATAAAGACACACTTGACGAACAGGGACACCGCATCCCACAAGACTCTGTCGGCTTTGACTCTGGTTCTATGCGCTACCTTTCTGAAGACTCTATGGCTGCTCTTTTTGGTAAGAAAGTGATGCAGTATCACCGCAAGAAGAATGCTTTGGAAGCAAACAAAGAAGCTCAAAAAGCAGAAGAGAAGAACGCTATTATACAGAGTTTTAAGAAATAAATATGTTTCTTCCGTTAAATCTATAGATGATTCTTACATAGTTTTAACGGAAGGACTGAAGTAACTTATTAAACAAAATGATAGGATAAAAACTATCAAACTACATATTTTATTTAACTCTCCGACGCAAGATACCTTTTCTTATTAATACCTCAAAGATACGGATAGAGATTTGAAAAATCATTACATAATTTCAAATAAAACATCTATAAATAAGGACAAAAACACATACAAAAGGAAGACTTGTAACCAAAAGGATATCAATTAGTTAGAAAGCAGCATATCAAAAGATGCTTAATTGGACGTCAAAAGGGCGTTAGTAAGGGGCTTAAAGGGCACCTTTTGCAAGCCAAAAGGGCGTCTTTAAGAAGCCTAAAGGGCATGTATTAGACTTAAGTCGTCTGAAAATAGTTTACATATATTGCTTAGTCAAGGAATAAGTTGTTTGTAGAAAACGGTCAGACACCAAATCTATTCACATTTTACCTTGTATTTATTCCCCTTTGTGAAAGCATCTAATTGGGGATAGTTATCGTAAAAATATGAGCGATGTAATCTAATAAACCGATTTAGGTTTAATCTTTTCAAGCACAAGATTTGGCTGTTATTACAATTTTATATACCTTTGCGCAGATAATTATAGAGGTAATTCAGCCGTCATATACATAGGCTAAAAAGCCTTTCACAACCAAGGCAGCAATGCCGTTATAAAAAGGAGACCACTACAGGTTTTAAGAATATGAAGAAATTAATAGCGTTGTTTTCAATCATAACAATACTCTCCTTCTCTTGCTCAACCATCGTTTCTGCACAGGCACCAGCCAAAGCAGCGACCACAGCTACTGCTGACACACTTTCAGATGATGCACTGAACGAGACAGGTGTAGCCGATACAGCAACCGTTAAAACACCAACCGCACAAGATACGGGCATCCACCAATCCTTAAAGCGTAAGTTCATCGAGGGTAATGCTGGCTTCATGTCGTTGGTAGCGTTAGCTTTGGTGTTAGGCTTAGCATTCTGTATTGAACGCATTATCTATCTAAGTCTTTCAGAAATAGACGCCAAACGATTTGTTGGTAAGTTGGAGGATATGATTGTTGCAGGTGAGATTGAACAGGCAAAAGCACTGAGCCGTGACACACGTGGACCAGTAGCTTCCATCTGTTATCAAGGTCTGTTGCGTATAGACGATTCTATAGAAAATATCGAACGTAGCGTTACCTCATACGGTAGTGTTCAGAGTGCTAACCTTGAGAAGGGCTGTTCATGGATTACACTCTTCATTGCAATGGCTCCATCACTCGGTTTCCTTGGAACCGTTATCGGTATGGTTATGGCATTCGATCAGATTCAAGAGGCTGGCGATATTAGTCCAACGATTGTGGCATCAGGTATGAAGGTGGCTTTGATTACAACCATCTTCGGTATCATCGTAGCCCTCGTACTGCAGATATTCTACAACTATATCCTCTCAAAGATTGACCATATCACAGCACAGATGGAAGAATCAGCCATCACATTGTTGGATGCAATCATGAAGTATAAACTTAAATCAATTCATAATTCATAATTCAAAATTCATAATTATGATTACTTATGAGTCACAATACATTAACAAATACTCGAATGGGAGCTTATTAGTAAGAAAGAATTATGATATTCATATTCAACTATTCTTACCAAGTTTCCTTCTGTAACAAACATAGAAGACATCGGTAATCATAATTATGAATTCTGAATTATGAACTATGAATTAAAGAAATAATCATAATTATGAATTATGAATTTTGAATTCTGAATTAAAGAAGTAATCATAATTATGAATTGTGAATTATGAATTCTGAATTAAAAAGTGGTATGATGAAAATAAAAGGTATAGCAAAGATGGACGAGGAACGCATATCACAGCGTGTCCTCTACGTGATAGTAGCCTTATCAGCTATTGTCTTTTTGGCATTCTATCTCATTGGCTATGACACCCCTTTTACAGGCAACACAGCATTCAATGCACCTATGCTTACCGACGTTTTGCTTGGGTTTATGTGGGGATTGCTTGCTATCACAACTACAGCCTCTATCGTTGCCGTAGTTCGAGGCATACGAAGAGCCAACCGAAGTGAAGGAATGACGAATGGTATTCCTGCAAGAAGGATTACCTATACTACATATGGAATAACAGCACTCATCTTACTCTTGACCTTTGTTTTCGGTTCTACGCAGACAATGATGGTCAATGGAGAGAACTTCACAGATAGCTTCTGGCTTCGTATAACAGATATGTTTGTGAACAGTTCACTACTTTTACTTGTTCTTGCAGCAGGAGTAGTAGCCTTTGGAGCGACTCGTTATTACAGAAAGGGACGCGGAAAATGATGTTTCGTAAGAGAGAACGAAGGAAAGTTCCTATACTAAATACGACGTCAACGGCAGATATTTCGTTCATGCTGTTGATATTCTTCCTTGTAGCCTCTTCTATGGACCTCGACAAAGGACTGTCACGTCAGTTGCCTGCTATCGACAAAACAAAGACACCACCTGCTGCCGTTGATAGCAGAAAAGTAATGCGTATTGTTATCGATGCGAAGAATCAAGTGACACTTGATGGAAAGGCTGTGACGATGAAGGAGCTCTTACAGCGTGCAACACAGCTTATTCAAACTAACGGAAAGGGGCATCTTATCCAGTTACAGAGCAGTCGTAACGCTTCATACGATACTTATATCCACGTGCAAAACCAATTAGTTGCAGCGTATAACACCCTTCGCAACCAACGCGCACTCAATCTTTTTGGAAAAGAGTTTGAACTATGTAGCAACGAACAGCAGAAGCAAATAGCCGACGAATTACCTATGCGAATATCAGAGGTGTATACTGTTAGCAAGGCAGACAACACAGAGAAAGGGGGTACAGAATGAAACTCTATCGCGGAAGAAATCATGAGATCCCTGCATTGAACACAGCTTCTATGCCTGATCTTATCTTTTCTATTCTTTTCTTCTTCATGTTAGTTGTACACATGAGGAAAGCAAACGTACACGTAAAGTACCAAGTGCCAATGGCAACAGAGCTTTCACGCATGTATAATAATTCAACTATACAGCACATCTATATTGGTCGTCCCATCAATAGCCTTGGACAAGTAGAAGGAGAGAAGATGGTTGTACAATTAAATGATCATATCACAACGATTCCTGAAATAAGGAAATATCTGATTCAACTCTCTGCTGCTTTACCGCCAGAACAGCGCAAAGAGCTAAGCGTAAGCATCAAAGCAGACCGCCATGCAGATATGGGTACGATTATGGATCTCAAACAAGTGTTGAGAGAGGCTAACGTGTTGAATGTCAACTTTACAGCCACAATGAGTAGGAATAACAAACTGAAGTAGGTTATAAAGTTGTAATTTGTTGTAAAAAACGACTTTTTAACTTGCTTATTAAGAGTTTTTTTAATACCTTTGTAAGCAAAATCAAATTGTAAATAATGGCACATAGAAGTTTAGATCGTCTTGATAAGAAGATTCTGCACCTCATCTCTGAGGATGCAAGAATTCCATTCCTTGAGGTTGCACGTGCATGTAACGTCAGCGGTGCAGCCATTCATCAACGTATTCAGAAGTTAACAAATCTTGGAGTATTAAAGGGTTCACAGTTTATTATAGACCCAGAACGTATTGGTTATGAGACCTGTGCATTCATTGGTTTGAACCTTAAGAATCCTGAGAAATTTGATGATGTTGTTGAAGCTCTGCGTCAGATTCCAGAGATTGTGGAGTGTCACTACACCACAGGTGAGTATGACCTCTTCTTGAAGATTTACGCATACAACAACCATCACCTTATGTCTGTCATTCACGACAAGCTGATGCCACTTGGTCTATCACGCAGCGAGAGTTCAATCTCTTACAATGCTGTTATCGACCGCACCTTACCTATTGAGGGCATGAAGGTTGCTGATGTCGTTCTGGATGATGATGAAGAGGACGAGGAGTAAAAATATTTCTACCTATAATTAATAGCGTAGAATAAACTAATATCCTTTTATAAAGGATGACCAATACAAAGAAACCCGTACAACATTTGTGCGGGTTTCTTCATTTTCATACTCTCCTACCCTATTCAACCAATTTATCTATCGATTTTATCAGCTCTTATCATGTCACTTTTCACACATTATCGAGTGTAAAAAATATTGACACAGAAATCAGTAAAAAGCCTCTTTTTTATGCTCAAAACAAACAAAAGCAGTACCCTTGTAACTTGCTATTAACCAAATAGTTGCACAATAGCATTTCTAAAGGTACTTAACAAGGGTTCAAAAGGGCGTTAGTTAGACCTCAAAAGGGCATCTTTTAAAAGCCAATTGGGCGTTAATTCAAACACTGCTAAGCATCAATTAAAATTGGCTATTTGATTTTTCTTGACAGAACCAATAAATTTAAAGACTTTAAGAAGAACTTAATAAGGAGGTACCGAACTCACAGAAACTTTATCATTTTATAAATAAAAAGTCCTCACAAGCAGAAATGTGCTTGCGAGGACTTTCCAATATAATTTATTTTAAGCTGTACAACAACTTACAGGCGACTCATTACCACTTGAGTACATAGGCTTTCACCCGTTGTCATACAACTATTATTCCTTGATATTTGGCTCTTCCAAACCGAGGTTGCGCTTCTTATCTACTACCTTCAAAGTAAGACCAATGATAAGAGCTATCACACCCAAACCAGCAAGCATAACCAACGGAGCTGTATAGTTGAGCTGTGTTGGGTCAGTAACACCTACGTTTGTCTTGTCGAGAACCTTACCAATAAGGAGTGGGAACAACCACAAACCGATATTCTGAATCCAGAAGATAAGTGCGTAAGCAGAACCGATAATCTTTGCATCTACGAGCTTTGGAACACTTGGCCACAATGAAGCAGGCACAAGTGAGAAAGAAGCACCGAGAACGAGGATGGTTACATAAGCTACGATAACACCACCCACCTGACTTGACTTAAACTGTGGAAGAACAAAGGCAAAGGTGAGGTGACAAACAATCAGAAGCAATGAACCTAAAACGAGCATAGAGGCAGCCTTACCCTTATGGTCAACATAGCTACCAAGGATTGGTGTAATACCTACTGCGAGCAGTGGGAATACAGCAAAGATAGACTCTGCAGACTGACGCATATAACCCATGTAGCAGTAAGCAACAAGGAAGAATATAGAAAAGAAGAGCATAAGATTCTTCAAAGCCTTATTCTTCATGAAGTTGAACATGAATGCAGTAGCAGCAACAACGAGCATGATAACATACTGTATGATAGTCACACTTGATGAAGCCCAGTATGAACCTGAAGGAAGTTCGTGGAAGGTAAGGTTACACTGAAGCATATTTACAGCGTACTTCTGGAATGGGAAGATAGCTGAGTAATAAAGCACACAGAGCAATGCTACGAGCCAGAAGCCCATACTTGAAAGAATCTTACCGAGGTCGCTAATCTTAAATGGATCTTCTTTTTCCTCTGCCTCACCAGTCTGTGAGTCGAGCTTCTTATCCATGAAGAAGTAAACGATGAACATCATCAATGCAATACAGATAAGTACTACACCGAAAGCTACAGAACGAGAAACATTAATATCGCCACCGAGTTTTGCAAAGAATGGCGAGAAAATCATACAGGTAGCAACGCCAAGACGAGCTAAAGCCATCTCTGAACCCATTGCCAATGCCATCTCACGACCCTTGAACCACTTTACAATACCACGAGAAACAGTGATACCTGCCATCTCAACGCCACAACCAAATATCATGAAACCACAAGCTGCAACCTTTGCAGAGGCTGGCATACCCTGATAGAAAGGAGATACACCCAACTGCTCGAAGACAGGAATGTGGTTGAGGTTATTGGTAAACCATACGTCAAGTGCACTACCAGCAAAGCTGTCGCTGATGGCATAGTACTTGATTAAAGCACCAGCTAACATCACTGCACCAGACAAGATAGCAGTGAAACGAACGCCCATCTTATCGAGGATGATACCTGCGAAGATGAGGAAGAACACGAAGACATTAAGGAATGTCTCTGAACCCTGCATAGTACCGAATGCGGTTGAGTCCCAACCTCTCTGCTCCTGCATCAACTCCTTGATTGGAGAAAGGATATCAACAAAGATGTAGGCACAGAACATTGCCAGGGATAAAAGGAGGAGAGCCGTCCAGCGCATCGCTGCTGAATCTCTCAATGATGTTTGAATTTTATCAGTCATGATGATTTTTTTAGTTAACAAGTTTACGAGAGGACAAGTTGACAAGTTTGACAAGTTGACAAGTAAACAAGTTGTTTGTTAGATTATAAGTTGAAAGTGAACGAGTGAACATGTTGACGAGTGAACGAGTGGATACTATCAAGCAACTTGTCTACTTGTAAACTCGTCAACACGTTAACTTGCAAAAGCTACTTCTTCAGCCAGCGGTCGAGCCAATTAAAGAATGTACGCTGCCAGAGAACACTGTTTTGTGGTTTCAATACCCAGTGGTTCTCATCAGGATAGAGAAGTAACTCAGCTGGGATACCACGCAGACGAGCTGCATTGAAAGCACCCATTCCTTGATTAGCATTAATACGATAGTCTTTCTCGCCGTGGATACAAAGGATTGGAGTATCCCACTTATCAACATTCAAATGAGGACTGTTTGCGTAAGTACGCTTTGCAGCTTCGCTCTTGTCCTTATTCCAATATGCATCGTCATACTCCCAGTTGCTGAACCAAGCCTCCTCTGTATCTGTGTACATACTCTCAAGATTGAAAGCACCATCATGAGAGATGAAACACTTGAAGCGCTTGTTGTGAATACCAGCAAGATAATAAACAGAGAAGCCACCAAATGAAGCACCAACAGCACCTAAGCGGTCTTTGTCTACAAATGATAGATTGTTAGCTGCATCGTCAATCGCTGAAAGGTAGTCGTTCATACACTGACCAGTCCAATCGGTACTAACTTCCTCGTTCCATGCACTACCAAAGCCTGGCAAGCCACGACGGTTTGGTGCAATGATGACATAGCCATTGGCTGCCATAATCTGAAAGTTCCAACGATAGCTCCAGAACTGAGAAACAGGACTTTGTGGTCCGCCTTCACAGAAGAGCAATGTAGGGTACTTCTTATTTGGATCGAAGTGTGGAGGAGTAATTACCCATTCCATCATTTCCTTACCATCAGTTGTCTTTACCCAACGAGACTTTACATCACCCAAAGCTAACTGGTCATAGATGTGCTTATTCTCAAAGCTGAGCTGTGTCTGAACGCTTGCTTTCTCCTTCTTAGCAGGAGTTATAGCGAAGATTTCATTAGCTTGAGAGATGCTCTGACGGATAGCAAGCAACTTCTTATCACCAAGGAGTGAGATACTTACATAGTTATGATCGCCTTCTGTCAGCTGCTTTACTTCGCCCTTAAGATTCGTCTGATAGACGTTCACCGTTGCATGCCATACACCAATGAAATAAAGGTCCTTTGAATTAAGGCTCCATGTGTAGTCGTCTACATTTGAATCAAAGCTTTCAGCAACGTATGTCTTCTTGCCTGTTGCCAATTCATAGACACAGAGGCGGTTGCGATCACTCTCATAACCATCGTTCTTCATACTTTGCCATGCAATGTACTTGCCGTCAGGTGAGAACTTAGGGTTAACATCGTAACCTACATTCATATCGCCAGCCTGATGATTTACAGCCTGATTACGCATACTCTTTGTAGCATCAATCTTTGGCTCAACATAGTCGGCTGGCTTGCAGAGATTCTTTGTTTGGCGAGTCTCCACATTATATATATATATGTCGGCATCGGTAGAGATGGCATATTGTGTACCTTCCTTCTTACGGCAGGTATAAGCAATGAACTTAGAATCCTTGCTCCAATCAATCTGCTCAATACCACCAAATGGTGCCAACGGACTCTCGTAAGGTTCGCCTTCGAGTACATCAATACCTGCACCGATACCCTCAGGAGTAACATCTGCAACAAATGGATGTGCATTGGTTGTAACGTAATGGTCCCAGTGACGATAGTTCATATCGGTGATGACCATACCCGTAGCCTTTGGCAAGTCGCTTGGGTTCTGCTTAATAGTGCCATAGTAAGGGATGCTCTTGATGAGAACAACACGCTTACGGTCTGGAGAGAATCGGAAACCTTCGATGTCGATATCCGAGTGTGTCAACTGCTTACGGTTAGTACCGTCTGCATTCATTGTCCACAACTGTCCACCTGTAAGGAATGCCAAGGTGTTGTTGTCGACCCATGCTGCATCACCCTCACTCTTTGCAGAGGTAGTCAGCAGACGGTCGTTCTTACCATCGGCATCCATCACGCGTAGTACCTGGTGTCCTTTGTTTTCTTTGACACTGTAATAACCCACCTGATAGACAATCTTCTTGCCATCAGGTGAGGCTTGTGCAGCACCGATACGTCCCATAGCCCAAAGTGTCTCAGGAGTCATGAGGTCACTTGTCAGCGTAATGTTGCTACGTCCGATGTTCACATCCTGTGCTTGTGCAACGCTACCACTCATCATCAGAGCCGCAGTCATTGCCATGGTTAAGTTTTTGTTCATAGTTATAGACCTTTCTTTTTCTTATTTAGCTCATCTTGCTTGCGTCGAAGTTCTTCTTGCTGCTGCTTCTGTAACTCCTGTAAAGCCTGCATACGAGCGAAGAGTCCACTACCCATATTGTTCTTAGGGTTGTTCTTTCGCTCTTCACGACGTGCTTCAAGGATAGCCAGAAGTTTCTCCTCATTGGTTGTCTTGCGCAATGCCCACATGATAGCAGCTGAGAAGAAGAGAGATATAAAGTAATAGAAGTTCAAACCTGATGAATAGTCATTAAACATGAAGAAGAAGAACAATGGCATACCAAACATCATCCACTGCATCATCTTCATCTGATCAGCCTGCTGTCCAACCATCTGATCCTTCTGCTGCTGCATGGTAAACCATGTGTAAAGCAAGTTAGCACCACAGAAGAGAATACAAGTCAATGAGATATGATCACCAACGAGCCAAACGTCATGGCTCCATGAGAAGATTGGATCGAAAGTACTGAGGTCGTGCATCCAAAGGAAGCTCTGACCACGAAGCTGAATAGCATTCGGTACGAAGTTGAACATCGCAATCCAGATTGGCATCTGTATCAACATAGGAAGACAGCCTGACAAAGGACTCACTCCATACTCAGAATACTTCTGCATCATAGCTTGCTGTTTCTGCATCTGGTCTTCTGGCTTATTGAATTGCTTCGTTGCTTCATCCAACTTTGGCTTCAACACACGCATCTTAGCAGAGCTCATATAGCTCTTCTTCACCATTGGGAAGGTAATAAGCTTTAATAATAAGGTAATGAGAATCAATACAACTCCCATTGGGAACACCTTACTCAACCAATCGAATACATAAAGAGTAAACCAACGGTTGATAATGCGGAACAATGGCCAACCAAGATATACGAGGCGTTCCATGTCAAGTTCCTTTGCAAACTTACTCTCTGTTTCAACAGACTGAAGCAGACGGAAATCGTTAGGACCAAAGTAGAATTCGAACTCTGAAGGGCGCTTACCTGTTGGATCAAAGCCAGCCTTCATGTTAGCCTCATAGTGCTTGAGGTAATGAGAAGACTTCTCAAGTGGTGTACTCTTAAGCTTTGCACCTGTTGCAAAGTTATCCTTTGCAATCATCACAGCAGAGAAGAACTGGTTTTTGAAAGCTACCCAATCCATTGAGTCCTCTGTTGTCTCTTCCTTTTCAGAAGTCTCACTCAAGTAATCAGTACCCCCATCATGCTTCTTATAGGTAAGTGTTGCGTAGCGGTTCTCAAATGTGAAACCACGTTCCTGCTGCTTACAACGCTCCTGCCAGTTAATATCTATCTGGTTATAATTTGGAGCAAAGAGTCCACCCATACCCTCTGCCTGCAAAGACATATTGAGCAAATAGTCCTTACCAAGTGTATAGTTCAAGGTAAGTGTCTTACCCTCTCCTGCCACAGCAGTCAGCGTAACAGTAGAATCTGTCACATTTGAAGGAGTGAAGATAAGGTCTTTTGTCTCAATATTACTATTCTTTGCAGCCAACATAAAGTTAAGGCTCTGGTCGTCACCACTAAACAAAGTAACATTCTTCTGGTCCTGTGAACCATCCTTAACAGCTATATTATGACCGATATAGTTTTTGATAACAGCCTTCTTTACAACACCACCCTTGGTACTCAAAGTCAGCTCAACCTTACTATTTTTCAATATAATATCCTGCGCCTTGCCATTCAAAGCAGCATAAAATAGAGCTGTAGTATCAGTAGCCTGCGCAGCCTTCTGCTGTGCCTGCTTCTCAGCAGCAAGTTTCGCGGTCTGTGCTTTCTTAGCAGAAGCGATAGAATCCTTTACAAATTCAGCTCTCTGCTGTGCTACCTGTTCAGCTGATGGCTGCTGCCACCAAGCAAAACCAAAGAGAATCAGGGCGATAAGTACAAACCCTGTGATAGTTCTTTTATCCATTTATTTGTTTTTCTGATTTTCAATTGAAGTCTTTACGAAGTCGAGGAAGAGCGGATGTGGACCGAGTACAGTTGACTGATACTCTGGGTGGAACTGTGTTCCAATATACCACTTCAAGCCTGGTATCTCAACGATTTCAACCAAGTCGCTCTCTGGGTTGCGACCAACACACATCATACCATGCTTCTCAAACTCCTTTTCATAGTCGTTATTGAACTCATAACGATGACGATGGCGTTCCTGTATATGCTCTTGCTTATAGATATTAAAGGTATGTGAACCCTGACGCAGTACGCACTCATAGGCTCCAAGGCGCATCGTACCACCCATATTGGTGATATTCTTCTGCTCCTCCATAATATCAATCACATTGTGTGTAGTCTTCTCATCAATCTCTCGTGAGTTAGCATCCTTATACCCAAGGACATTACGAGCAAACTCAATCACCATCATCTGCATACCAAGACAGATACCGAAGGTTGGGATATCGTGTGTACGTGTATAGTGAGCAGCAACAATCTTACCCTCAATACCACGCTGACCAAAGCCCGGACAAATCACAATACCATCCTGTCCCTTAAGTTTCTCAGCTACATTCTCCTCTGTCAGTTCCTCAGAATTGATAAAGGTAATAACCGTTTTACGGTCATTATAGGTTCCAGCCTGCAACAAGCCTTCACGAATACTCTTATAAGCATCCTGCAAGTCATATTTACCAACAAGTCCAATGTGTACTTCCTTAGTTGCTTTACGCTGACGATCAAGGAACTCCTTCCAAGGACCGAGTGCAGGCTTAGGACCAACTTCCTCACCGCACTTACGCAGAATAGCAGCATCCAAGCCCTGCTCAAGCATATTCACAGGAACATCATAGATACTTGGGAGGTCCTCACTCTGTACAACGCAGTCGAAATCAACATTACAGAAAGCAGCAACCTTCTTACGGATATCATCATCAAGATGCTTTTCTGTACGCATCACGAGCACATCTGGCTGAATACCTACACTCTGCAATTCCTTTACGCTGTGCTGAGTTGGCTTTGTCTTCAACTCACCTGCAGCCTTAAGATAAGGAACATATGTCAAGTGAAGGTTGATGGCACGCTTACCCAATTCCCACTTCAACTGGCGAATAGCCTCAAGGAATGGAGCTGACTCAATGTCGCCAATAGTACCACCAATCTCAGTAATCACAAAGTCATAGTGATACTTCTGCCCCAAAAGCTTAATATTACGTTTGATTTCGTCCGTAATATGAGGAACAACCTGAATAGTCTTACCCAAGTAGTCGCCACGACGCTCCTTGTCAATAACGCTCTTATAGATACGTCCCGTAGTCATAGAGTTGGCTTTTGTGGTCTTAATACCTGTGAAGCGCTCATAGTGACCGAGGTCGAGGTCGGTCTCCATACCATCCTCTGTTACGTAGCACTCACCATGCTCGTAAGGATTCAGCGTACCTGGGTCAATGTTGATGTACGGATCAAATTTCTGAATGGTAATGTTGTAACCTCTTGCTTGAAGAAGCTTACCGATTGATGACGAGATAATTCCTTTACCAAGTGAAGAAACTACGCCGCCCGTAACGAAAATGTACTTTGTTTCAGCCACGATGTATGTATGTTTAATTATTATCTTCTAAAACGAAAATCGTTGGTTCTAAACTAAAATGCAAAGATACTAATTTTCCATGAATTAGGCGGGATATAAAGATAAAAAAAACATAGTATATTTCATTTAATTGCCACAAGACCTATGAACAGTGCTATCATCTATGATTACAATGAGATTTTATCTACCTTATGGCAGATTTTATTATTACAAAACTAAGAGACATTTTAATAAAATATTTTGCAATAAAACACCCCTTTCACAAGACTAAATCTTATATTTCAAACAGTTACTATTACATAAGAAAACTACAATTTAGCAATAACGAACTAAGAAGAATATCACAAGAGAAGACTACTCTAAAACTTTAAAGAAACTTAAAATCCTCTTTACTGCCGCATTATTGTAAAACTAAAGTTCTATTTTTGCAAACCAATTTGAGGCTAACATATAGACGATATACGTTAGGATTCACAAGGAAAGATGCTCGAGTGGTTGAAGAGGCACGCCTGGAAAGCGTGTATACCCCTAAAGGGTATCGGGGGTTCGAATCCCCCTCTTTCCGCAAGAAAGGTGTAAACCAATGGATTACGTGGCTTGCACCTTTTTCTTTTCTGACAACTTAATATAGAAAGGGAAACATTCTAATAACCACAACTACACATCCTTACACAAAACACGTATTTTCCAATTCATTGCTTGTTATACGGCTTTATTTTCCTAACTTTGCAGAAAGTAAGATTAGGAAACGGATATTGTATCTACGTAATAACATCCAAATTTAACGAAAGAAATGATAGAACTCGATACTACCAATATGTGTTCACACCTGCAGAAGAAGCTCTTTAACGAAGAAGGTGTCTACTATCCTATATGGCAGGCGATGCAGAATGATGATGAGATAACAGCTGTGATTCGTTCACGACAGTTGCATATCTACCGCAATGGTAAAAAAGTTTTGGTGCTTCCCGGCAAGGCTGCACCGAAGATTATTCGCGAAGATAGCCTCAACGAACTCTTACCTAAGGACTTACTGAAATGAAAAAAGCAATCGTCGTAGGCGCCAGCAGCGGTATCGGACATGAAGTAGCACGACTGCTCATCGCAGAGGGATGGGCGGTTGGTGTGGCTGCTCGTCGTATAGACAAGTTGACAGACTTGCAAGCTATGGCACCAGAGCGGGTCTACACAGTCCAAATTGATGTAACTAACGAAGATGCAGAGACTTCCTTACTGCAACTTATAGAACGTATGAACGGCATCGACCTCTATTTTCATGCCGCAGGAATCGGTTGGCAAAACCCAAGTCTTAATGCTGACATAGAACTCAAAACAATGGAAACCAACGCTGTTGGATTCACCCGAATGATTGGCTGTGCCTATCGCTATTTTGCCAATAAGGGAGGTGGACACATCGCTTGTATCACTTCTATCGCAGGAACAAAAGGGCTCGGACCGGCTCCTGCTTATAGTGCAACAAAGGCGATGCAGAACACCTATCTACAAGCGTTGGAACAACTCGCAGCTTGTAAACATCATAACATCCACTTCACAGATATTCGTCCCGGCTTTGTCGACACTCCCCTACTCGCTGGTACCTCTCACCTCCCGATGCTGATGACCACAAAAAAGGTGGCACGCAGTATTATAAAGGCTATTAACAGCCGACGACACATCTGCGTCATCGATAGCCGTTGGTGCGTACTCACCTACTTATGGCGACATATCCCTAACTGGATATGGAGGCGAATGAAGCTATGTTAACCTCTTTTTCATACAAAGAAAACAAACAAGATTTCCACAACAACATAAACAAACACTAATTTCTTTCCTCATAAAATAAACTTTCAGGGTTTTCAATCATCTAAGCATATAAGTCTTAAAACTGTCCATAACGAAAGGGAAGGAAAAGGATAAGTAAAAAAGGAAACAACAGATAAACAAGTAACAAAACAATAATTATTTAGGATATGAGAAAATTCTGTTTAAAGATTCACCGTTGGTTTGCTTTACCATTAGGCGTAATAATGGCTATTTTGTGCTTCAGCGGTCTGGCAATACTGCTAATAAAAGACCTTGCACCCCTCTTTGACATGAATGCCAAAGAGATGCCAATCTATACAATAGTAGTACGACTGCACCGTTGGCTCTTTATGAAACCTGAGAATGCACATGAGGGTGGACAGTCACTTGGACGCATCCTTACAGCCGTGTCAGCAATCTGTATGTCAATCGTATTGTTATCGGGTGTTGTCATCTGGTGGCCAAAGACCAAGAAGGCGTTGAAAAGTCGTTTGACCGTCAGCACTAACAAGGGTTTCCGTCGCTTTGTTTACGACTCTCACGTGTCATTAGGTATCTATGTCTTTATCTTCCTTTTCCTCATGGCACTCACTGGTCCTGTCTTCTCTTTCGGCTGGTACAGAGCGGGAATGTCTAAACTCTTCGGTCAGCCTATGCCACCAAAGGAAATGAAGATGCAACAGCCTAAAGATGGAATGAAGCAGGGCGGAACAAACGACAAAGCTTTTGCACCTACGGACGCAAGTCAGATGAAAGGACAACCACAAGCACACAAGGAGGGAGCAAAAGATATGAAAGGCGATCAGCATGGTAAGAAGCCAAAGGGTGGAAAGCTCTTTAAGCAGTTACACACAGGAACATGGGGCGGATGGTTCTCACGCGTTCTCTATGCTATCGCAGCCCTTATCGGTGGTTTCCTCCCTATTAGTGGTTACTATCTGTGGTGGAAGAGAAGAAGTGCTAAGAAGAAAAAAGCATAAAACATAATCATCATATATCACAAGTCCATTGATTGTATTCGGTTGATTAACCTACAGAATACCATCAATGGGCTTTTACATTTATCCTTCAACGAAGCACTTACCTAAATGTACTGACAAACTCCCAACTACATTCATCCACTCACAGAGGATTAAACAACCAATATTATGTAAAGATTATTCAAACTACTAAAAAACAACTAACGCCCAATTAGACTCGAATTAAGCCTTAATTGGCTTTCAAAAGATGCCCTTTTGAGGTCTAACTAACGCCCTTTAAGAGTCTAAAAGATGCCCTTTTCAAATCGTATTTGTAAGAGTCTGATTATCTGACCGTTACAAAGCCCCATTTTTAGAGCGGTTTTCTATAAACAAAAGGCTTACAGAAAGCGTATTCTGTAATTATTTTTCACAGTCCACAAACCCAATAAACCATAACTAATAATCAAAATTATGTAATCTTTATTAGGGATAAGAAAACCTAATCACACAAAAAATCAACAATAAATTACTTATAAATGAGTATTGCCACCTTAACAAGAAGCCAGTACCTTTGCACTCGAAAAATTTTACAGACCATAATAACAATAATGATGTTATATAGAATATTAAATAAGGTGATAAGTCTGGTGGAAGACTTGACTTGCCGAAAAGTAAATCAGAAATACGTGTTAAAAGAACATATTTGTATTTATTTACATGCGTGTATAAGATGAGAAATAAATAACAAATGATTAGTTTATTTTAACCAAATCGACTTGCTTTTGTTCTTATCAAATAATATATTTGCGACAGATAATCTAATTTGGCGCGAATAAGATAAATACCATCATTTAAAGCTTTTACTCATTTTTAAATACCAGACAAAGAGATTTTTCTCTTTTAAAAAAGTCTAATCAATATTATATTTTATCTAATAAAACCCTTGAAGAGTATGGAATTAAAAAAGACACTCTACTCCCTAATGTTAGGTGGCATTCTTCTTTGCTTGTTCTCATGTGCAAAGGAAGACGAATTTGAAATGCCAACACTGGTGCTTTCTGAAAACAGTATTGCCTTTGATAAAGGCGTAAGTGAAAGAAACATTAGTGTAACAACAAATCAAAACAGCTGGATTGCATCGTCTCCACAGGAAGGCGACTGGCTCTCGCTGGTTCAGGACGGTAACGTACTGAAGGTGAAGGTAACTGAAAACAAGATTGGAACAGAGCGCACAAGCTACGTACTCGTTAATGCCAACGGCGCATCTGGTAAGATTGCTGTGACTCAGAGCGCAGCTGACGTAACGCTTGACGTGGTTCCAAATGCTATCTATCTGCCACAGACAGGTGGTGAGAAGACGATTGACATTACGACGAATTCGTCTGTCTATGACGTAACAACCAGCGAAGAAGTTAGTTGGTTAAAGATTGTCAAGTCGGAGGAAGAAATCAAACTGATAGCTGAGCGTAACGATACCTATCAGAAGCGTGAGGTGAAACTTTACGCCAAGAGCGGTAGTGTTATCCGCGAGATTGTTGTTTCTCAGTCGGGTATTCAACGCTACCTCCTCCCTATTCATCCAGGTGTACCACAGGACGAGCATAAGATTATGGACTTTGAGTTGGGTCGTGGTAGCTACTTGCGCGAGTATCAAGCAGCTATGCCAGCTTACGGCCTTGAGGAGACTTACACCTTTATCACTGCTTCGCCTATCTTTACTTTGATTCAGTATTGTAGCACTGATGGTATTAATCCGTCACAGATTATCATGATTGGCGATGGTAGAAAGGCTATTGATGCCGTGAAGGACAAGGCTTTCGATAAGTTCTTGACTGACAATGGCTATGTGCGCAGCAACTCTCAGTCTGACAGAGAATATACCAATGACAAGGATTTACTCTCTTTGAAGGTTTATATATCAGAAAAGGAGAATAACGAAGGAGTTAACCTCACTTTCACACCTATTATGAAACAGAATGGCGAATACAAGACTTTCAGCAAGTTACCATTCTATCCTCTTGAGCTTCTGCAGAAAGACAACGTGAAGTTGGCACAGATTGAACAATACGAGCAGAAGGCTGGTAGTACAGAAGAAGAGCGTAGCCTCAACGAACATAAGAATACTGAGGTTTCACAGATTCAATATAAACTGAAGGCAAGTACAGACCCTTCTGCAGCCTACGGACGTATTCACATCTTCTACACAACGGATAAGGATGGTGATGCACCAGACAATTTGGGTAGTGTTCAGATTGGTGCATTACTCTTCAAAGACACCAACCTCGGTGTATGGAAGTATGGTACTAAATGGGTTGCAACCAAAGAAATCAAGAAGGTATTGGGTGATGAGGGCTTCTCTTTCCTCCGCACATCAGGCAACAACCACTTCTTTGTACGTGAAAGCGACCACTTGGTTATTGATGTTACCTGCGTGTTAGACAACGCTATGCCAGTACTCGCATTGCTTTACAGCTACGATCCATCCGTATCGGGTGCAAGTAGTAAAGCCATAAAGACACAGGCTAAGATGATTAGAAACTTCGCTGCTGCCAAGAAGGCTTTGAAGTTCTAAGCAAATTGTTATACCTTATTTAAATAATTACATGATATGCGTATAATCAATATACATAAGCTGCTGCAGTTCTCTCTGCTATACCTATTATTAGGTATAGCGGTTGGATGCGCTGAGAATGACAGCTTTGACCAGCCCTATCTGAATGTTTCAGAGAAGGAGATTTCTTTCTCTAATCAGATTGGTGAGAAGACAATTACCGTAAACACGAACTGTAAGGAGTGGATGGCTACTACACCGAAGGCGTGGGTACACCTTTCACAAAGTGGAAACGAGATTGCTGTACACGTTGATCCTAATACAACAGGAATGGAGAGAAGTAGCTATATCCTTGTTGATGGTGGATTGGCAGTGCAGAAAATCATGGTAAGTCAGAGTGCTGCTGACATCACATTAAACTTAAACAATGGTGAGGTAATTCTGCCACAAGCAGGTGGTACGACAACTGTCGACTTGAAGATGGATGCTACTTCCTATGACCTTACACAGAGTGAGCAGCCAGAGTGGATGCAGGTTATCAAGAAAAAGCATGGTTTGAAGTTTATTTCTAAGCCTAATTATAGCACTACGGAAAGAACCACAAAACTGACAATAGCCTTTGCAGGAAAGAATCATGAGGTGGTTGTTAAGCAGCCGGGCGTAGCTACTTTTATCTTGGCTTGTAACCCAGGTAATCCTTATAGCTTGCATAAGATGATGGACTATGAGTATCGCCGTGGTAGTTTCTTGACGGAATACGGCGGCCCTGACGAGGTAAACGGCATCTTTGAAGAGAGTTACTTCTTCAAGACTCCATCGCCTTTGTTCAAAGATGTGGTTTATGTACACGACACAAAGCACTCTGTTCCAACGCGTATCTACACACGTTCACTGACAAGAGAGGGTGTGAACGCTGTTAAGTCGCAGGCTTTCCAAGAGTTTATGAGAGCCAATGGATATACAAGGGACGAGAAAGATACGAATCATTACGTCAATATAAAGGAAGCTTTCACGATGGATGTAGACATTAGAGAGGAGAATAATAGCGTTGTGTTATTCTTCTATCAGATGCACACACAAGACCGTAGCTACCCTACCTTTAGTAGTCTTGACCTTGGTCCTGTTGACCTTTTGAACAAAACTGACAAGAAGATAAGTGATGTCGAAGCTTATGAGACAGGTAAGAACAGTGAGGAAATGAAGCGACAAATGTCTAAGAGTAATGAGGTTGAAGCTATTCTCTACAAGACAAATGATCCTACATTGATTGCTCGTACTTACTTCTTCTATCTTCATAATGATGCCGCTGTACCACAAGAGAAGGCTGGAAGCGTTGAGCAATACAGTTTATTCTACAGCCAACCAAACTTAGGAATATGGCAGTATGGTAATGAATGGTTCGTAACCCATGAGTTCGACAAACTGCTTACTGCAAACAACTTTGAGTTCGTTGGCTACAATGGTAAGCATCATGTCTATGCGCGTCGTTCTGACTATCTGACCTTAGCAATCTCAGGTGGAGAATATGCTGACGTCAACAACGGTAAGGCAGTCATGCAAATTACTGTTCTATACAAGCCAACTGTCTTTGCAGGAAGTAAAGAACAGCGGTTGGCTAAGGTAGAACGTATGCTCAAACAATACAATCCAAAGAAATAAAATAAAGGAACATTGATGAGAAAATCGATTATATATCTATGTGCGTGTGCGCTCTCTGGCATGATGGTTACTACCTCATGCCAGGATAACTTGGACTCGGATGCGGGCGTTTCCAACACACGCTCTGTCAATATTGACAAAGACCTTTTTGCCATAAAAGGCTGTATTAACGTGAAGTTGGCAAAGGGTACAAACCAAGCTATACCTACAACGCGTAGTGGTAGTGTGGAAATGCAGAGCGTCCCATCGGCTATGACTTCTGCAATGCAGTATTCTGGGGCTTATAAAATGGAAAGAGTCTTTAAGCCAGCAGGTATCTATGAAGCACGAACCGTAGCTGAAGGACTCGACCGTTGGTACACAATCTATTTTGATAAGAGCAAAGATGTGGCTGCTGTCTTAGACCAATTCAAGAAGGCTGAGGGTGTTGAATGTGCAGAACAAGTACTACCAATGGCAAGACCAACGGTTAAGATGACTCCTTACAGCCCTTCTGGTGCAAGTATGCAGGCTACAGCAAGTACTTTTGATGACCCTCTCTTGGCTAAACAGTGGCATTACTACAATGACGGTTCAGTAAATGCACGTGCGAAGAAGGGTGCTGACTGTAATGTTAAACCTGTTTGGGAAAAGTACACAACAGGTAAGAAAAACGTTATTGTTGCCGTTGTTGATGGTGGTATTGATATCACTCACGAGGACTTGAAAGACAATCTTTATGTCAACGAAAAGGAGAAGAACGGTCAACCGAACGTCGATGATGACGGCAATGGCTTTGTTGATGACATCTATGGTTACAACTTTGTGACTGCTAAAGACGTCGTTGGCGGTACTATCGAACCCGATGATGGCGGACACGGAACCCACGTTGCGGGTACTGTCGCTGCACGCAATAATAATGGAAAGGGTGTGGCTGGTATCGCAGGTGGCGATGGTTCGCCAGATAGTGGTGTACGCTTGTTGAGCTGTCAGATATTTAGAAACAAAGACGAGCAGGGCGATGCGGCTGCTGCCATTAAGTATGCAGCTGACAACGGGGCTGTTATCTGTCAGAACTCATGGGGATATTCCTCTACTGCAGGTGTCACCTCTATGCCTCAGTTGCTGAAAGAAGCAGTGGACTACTTCATCAAGATGGCTGGTTGTGATGCTAACGGCAACCAACGTCCAGACTCTCCAATGAAGGGTGGTGTGGTAATGTTCGCTGCTGGTAATGAGAACAAAGAGTTCTCTGCTTACCCTGCTTGCTATGCTCCGACGGTTTCTGTCGCTGCAATGGCATGGGACTTCAGTAAGGCAAGTTATAGTAATTACGCTAAATGGGTGACCATTACGGCTCCTGGTGGTGATCAAGACCGCTTCGGAACAGAGGCTGGCGTATTGAGTACTGTACCAAAGAAGAAGGTTGCATCTGGTTATGCTTACTTCCAAGGAACATCAATGGCATGCCCACACGTGTCAGGTATCGCAGCACTCATCGCCTCTTACTTCGGTCGTCAGGGCTTTACAAATGAAGAATTGAAGTCACGTTTGATTACAGCTTATCGCCCTTATAACATCGATGAGCAAAACCCAACCTACAAAGGTAAGTTAGGTAAGGGTTATATTGATGCCGAAGCAGCCTTCGAAACTGATACAAAGATTGCCCCAGAGAAGGTGGGTACACTCACGCTCAAGCCTGATTTCGTGGACATCAATGCGGAGTGGAGCATCGCCAAGGACGAGGATAAGACTGCAGCCTTCTATCGACTCTACATTGCTCAGGGTGAATTGACAGCCGATAAACTCAAGGATATGACCTACAGAGAAATCAATGGCATGGGTCATAGCTTGGGTGAGACACTTAAGTATGACTTTGATGACTTGAAAGACAACACCACCTATAGTGTTGCAGTGGTAGCAGTAGACCGTTGGGGCAACCTTTCTGAGCCAATGATTCAGAAATGTACGACCCGACTCAACCATGCTCCAGAGGCGACAAACTTCCCAACAGAGGCAATAGAGGTCATGGAGAACGATCGTAAATCATTCTCTTTCAACGTTGCTGACCCTGATGGTCACAACTGGGACATCAAGGCTACGGGTGAGACAAAGGGCGTTTCTTACACTGTGAAGGGCAATACTGTGACCGTCAACCTCGTTCCTGTGCTCGAAGCTGGTAGTTACAACTGCACCTTTATACTCTCAGATGACTTAGGAGCAAAGGCAGAGAAGAGTTTTACATTTAAGATTGTAAAGTACATCCCACCACAGCTAACAAAGCCTTTCGAGAACTATATCATTGGATTGGACGAAGGAGTTGTAACTATTCCATTGACAGGTCATTACACACATAGTGGCAATACTCAGCTTACTTACAAAGCCACAGCTGCCAATGGTAGTATTGCTACAGCTACTATCAGCAATGACAACCTTCAGTTGAAGGGAATGGCAAAGGGTGTTACACGTATCAGCATCGCTGCTACAGACGGTCGTGAGACATCTTCTGACGGTTCTTTCCAAGTACGAGTTGTTGAAAAGAAGTCGGCTCCTGTCTATGCCGTCTACCCTATTCCAGTACAGAGAGACATCCATACCCTACTCAATCCAGAGGTGAAACAGGCTGAACTCGTCATCAGTTCTACTGTGGGTGAGCGTCTGATGAAGGCTACTGTGACTCCAGATAAGAACAACGTAGCCACACTTGACCTTTCTAAACTGAATCCTGGAACGTATAAGCTGACCGTATATACCAGTAAGGGCAACCATACCCAGATGTTCATTAAACGATAAACACAACAAGTATGAATACAAAACATATCATTCTCATGGCTTGCGCAGCACTTCTCGGTGCTACGCAGGCTAATGCTCAGGGACAAGATCTCTCGATATTAACAGCAAATACCGATGCCCGAACAGCCGCTATGGGTAATGCTTCGGCTGCTGCTGAGGGCATGTATCTATACAATAATCCTGCTGCTTTCTTCGCAACTGATAAGAAGTTCACCGCAGATGCTTCTGCCTCTCTCTTTGAAAAGGCAGAGGGTGCCGATGGAACCTTCGGTATTTACGCGCTTTCTGCTGGCTATAAATTGGCTAAGCGTCATGCTGTCTTTGTTGGTTTCCGCTATGCTGGAGGACTAAGTCTAAAGGGTTCCGACCTCTTGGGCAATCCAACCAAGGACTATAAGCCTTATAACTGGACCCTCGACTTGGGTTATACCTATTTCTTAGGTAAGGGATTCGCTACCTATGCAACAGGAAGTCTTATCTATAGTCACCTCTCTAAGAATGCTACAGGTGCTGTTTTCAGCGTGGGCGGAGCCTATCAAAACAACGAGTTGACCCTTGCCAACAAACCTGCCAACCTCATGCTCGATGCGAAGGTGGGTGCCATTGGTCCTCAACTCGACTATGGTAACAAGCACAAGACGACGCTCCCAACCTATCTTGCCGTAGGTGGTGCGCTGTCTGTAGAGGTAGCCGAGAAGCATCAAGTTGCTGCAGCCTTGTCTTCTCGTTACTTCTTCCAACCTTCAGAAGCCAAACTCTTTATGCTTGGTGGCGGACTTGAATACACCTATAATAAGATGGTATCAGTGCGTGCAGGCTATGAGTATGGTGACCACGACCTCAGCCATGTCACTATGGGTGCAGGCTTCAAGTACCATGGCTTACGTCTGAACGGAGCTTACAACCTGAAGACAGCAGACACAGGAAGTAGCTACTGTACCATAGGTATTGGCTATGATTTCTAAAACAAGGACAAACAAAACAATTCATTTAATCAAAAGTAACAGTTATGAAAAGAACTTTATTCTCAATTTGTGCATTAGTACTGAGCCTTACAGCTTCCGCTCAGATAATAAAAGACACACCTAAAGGTAAGCTGATTGAAAACCTGTATCGCTCAAGCAAGTCTTGGGTTAAGAAGGGTTGGACAGGTGTTCAGCCAGGTAGATATGAAGGCTTGGTATCTAAGATTGTTATCGGCGAAGATGGCTGTATTTACATTTACAATCCACTATCAGGACTCGACAGCAAGTCATGGTTGAAGCTTGAGAGACAACCTGATGGTAAGTATAGAGCAAAGCTACCACAGGATATCCTTACAGACGACTACGGTGGGGACGATGATGAGGAGGAAAGTAGCGAGCGCACAATCTCTCTTACTCGTTTGGTTTCTTCTGATGATGGAAAGAATTACGAGCCTATTGGTGCAAATAACTACGTAGATTTCACAGTGGAAGGAAGAACACTCAAGATGTCTGGTATGGGTCAGAAAAAGCAAATATGGGGTGCTTCCTTTAATAATAAGTGGGAAAGAAACTATGGTGGCGACTGGGCTCTGACGATTGAACCACTTAAAGAGCAGCTTATTACACCACCAGCTACAGCTACAAAGAGCCAGTACACCGTTACTTCTAAGTCTGATCCTTCACCACGTATTGTTGAAGTAATGACCAATAATAACGATATCTATGTCAAGGGCTTGTTCAAGGCTGAGAAACTTGCAAACGTTTGGGTGAAACTTACCAAGCAAGGCGACAAGGCTGTCATGCCTACTAATCAGTATTTGGGTATTACTAAGAAGACAGACTTTAAGAAATACGATAGCGATAAGTCGGAATATCACACCTTTGCCGCAGCTTTCGAGAGTGAGACCAAGGCTGCAGAGAACCTTGAGTTCAGCATTGATGCAACTGGTAAACTGACTGCTTCTAAGATTCTTAGAACTTCTTTAGGTAGAGCAAGTAATGATAACATTACTGGTGAAGACTATATAGAGAGCTATGAGGGTCTTACCTTGACTCCTTACGTTCAGAAGGAGGTTGGAGCCCCAGCGACACCAGAATACTTCTATTTAACATCTACTCCAAACTACGACAACACGTCTAATGAGATTAAGTTAGCATTCTATGTAAAGAACGCAGATATTAATGGCAACGTTCTCGACCCAGAGAAGATGTACTACAATGTCTATATTAATGGCAGTACAGAACCTTTCAAGTTCAAGAAGAGTGCAAGTCAATACAATGACATGCATGAGGAAGAAATGACTAATATTCCTTTCAACTACAAGGACAAGAGAAATTATGACTTCAAGGTTATCGATAACCTACGTATTCTTCATTTCTATGACAGTTCTATCACACGCCTCAAGGTCGTAATGGTTTATGAGTCTGACGGCAAGAAGTATTCAAGCGAACCAATGGTTGCCTCACTTACTACCGATGGTATCGAGAGTGCAAACTTCAACAAGACTACAACAGAAAAGTATTACACCGTTGATGGTCGACAGATTCAGAAGCTACAGAAGGGTCTTAACATCATCAAGTCTTCTGATGGTACTACACGTAAGGTGGTTGTCAAGTAAACAAGTTGACGAGTAAACAAGTTGCTTGTATAGTTGGCAAGTGAACGAGTTGACGAGTAAACAAGTTGCTTGTGTAGTTGACAAGTGAACAGGTTTACAAGATAATTGTATAGTTGGCAAGTGAACGAGAAAATAGTTATATCTATTATAACTAACAACTCGCTTACTTGCCAACTTTTGTATTTGAGAAAGACTGATATAATTCAGAATTCATAATTATGATTACTGCTTTAATTCAGAATTCATAATTCATAATCCATAATTATGATTACTGCTCTAATTCAGAATTCATAATTCAAAATCCATAATTATGATTACTAATATAATTCAGAATTCAGAATTCAAAATCCATAATTATGATTACTGCTTTAATTCATAATTCATAATCCATAATCCATAATTATGATTACCGACAAAGATAAAGTTTAAAGCTCAATATTCAAATCATAAAGCTCAATATTCAAATCATAAAGTTCAATGTTCAAAACTCAAAGTTCAAAGGTCTAAGAGTTCAAACATCAAAGGTCAAAGGACTAAGAGTTCAAACCTCAAAGGTCAAAGGACTAAGAGTTCAAACCTCAAAGGTCAAAGGCAGAGGGGTATCTCGCTATCTACTCCCCTTCCCTTGGGGGAGGGGTAAGGGGGAGGGGCTTTTTGTCACATTTTTTCGCACATTCCAAATCCAACACATGCTCTTTTAGCTTACAATTAAAGCCCAATTGGCTTGCAAAAGATGCCCTTTTGAGCTCCAACTAACGCCCTTTTGGACCCTTACTAACGCACTTTAAAAAAACAATCTTGCAAGTATTTGATTCTCTGTAAGTTACAAAACCACCAAGATTAGCCCTTTTAAGACCATTTTTCAACCCAAAACACACCGAATTTTGTAAACATATTTCACCCTCACCCTACATTATCAACTGGTTATCTCATCCCCTTCAAAACCTGTTAAACATGTTACCCTGTCTCCTTGTCCCCTTGTTACCCTGTCTCCCCTTACCCTATCCGCAAACAACTCGTTCACTCCTCAACCAGTCAACTCGTCAACTTATCCACAAAACCTAAGGTATTCTTGTATTATTTTAATATCTTTGCATAATCATTAAAGAGTCAATACGCAAAAAGAAAAATAAGACAATGACAAGTACCGAACTTAAAGACCTCGAAGGCCGTCTGTGGCAATCTGCCGACATGTTACGTGCTGGTGCACACCTTGCAGCCAATAAGTATAGCCAACCTATCCTTGGTCTTATCTTCCTCCGTTATGCCGATGTGCTTTTCAAACAGCATAAGGAGGCGATTGATACAGCCTATAACGAGTATAAGGGCACACGCATGGAGCGTAGCTATAAGGACATAGCCATTGAGAAGTGTGGCTTCTTCTTGCCTGAATGTGCTTATTTTGATTACCTCAATGATGCCCCCGACGATGCTCAAAAGGCGTTGTTGGTAAAGGCTGCGATGGAGGCTATTGAGCATGAGAACCCACGCATGGACGGCGTTCTGCCAAAGGAGGTCTACGGACAGTTGGTACCAGAGGAAGAACCGGAGCTACTGAGCCGTATTGTACGCGTATTCAAAGACATCCCTGAGAATATCAGTATTGACATCTTCGGACAGATTTACGAATACTTCCTTGGCAACTTCGCCCTTGCTGAAGGTCAGGGAGGAGGAGCCTTCTATACCCCTGCCAGTGTCGTACAGTATATGGTTGAGGTCTTACAGCCTGCCACTGGCGACAAGAAGTTTCTTGATCCTGCCTGCGGTTCGGGCGGTATGTTCGTTCAGGCAGCACGCTATATGCACCGCCACAATACCTCTAACGAACAGATGATGAACTTCCGTTGCTATGGCGTGGAGAAAGAGCCTGACACGGTGAAGTTAGCAAAGATGAACCTTCTACTCAACAATGTGCGTGGCGAGATTATGGAGGCTAACTCTTTTTATAGCGACCCTTACAATGCTGTCGGACAGTTTGATTATGTCATGGCTAACCCTCCGTTTAATGTCGATGAGGTGGTTGTTGAGAGGGTGACAGACGATGCACGCTTTAACACCTATGGTGTACCACGCAACAAAACAAAGTCTGCAAAGAAGGCTTCTGACAAGAAGGAGACCGTACCTAATGCCAACTATCTATGGATTGGCTATTTTGCCACAGCCCTCAACGAGCAAGGAAAGGCAGCACTTGTCATGGCAAACTCTGCCAGCGATGCAGGAGGCAGCGAACTCGAGATACGTAAGAAGATGATTGAGGACGGCATTATCAGTCAGATGGTGACCCTCCCCAGCAATATGTTCTCTACCGTGACCCTCCCTGCCACACTCTGGTTCTTCAATAAGAAACGACCAAAGAAAGACGAGATTCTCTTTATTGACGCTCGTAACATCTTTACACAGGTAGACCGTGCACACCGTAAGTTCTCTGATGAGCAGGTGAAAAACCTCGGAATCATCTCTCGCCTTTATGAGGGCGACAGCGATGCTTTCTGGGCATTGGTTGAGGAATATAAGGCAGAAGGCAAGCAGAGCGAGGCTGACTGGCTCTTAGAACGCTGGCCAGACGGCAAGTATCAAGACATTGTCGGGCTGTGCAAGGTAGCGAAACTTGAAGGTGAAGATGGCATCATCGACAACGATTATAGCCTTAACGCAGGACGATATGTGGGCGTAGTGATTGAAGACGACGGAATGACCGAAGAGGAATTCCGCACCGAAATGCTATCGCTAAACTCGGAGTTTGCCAAGCTGTCGGCTGAAGCTAAAGACTTGGAGAGTGAGATTGAGAAGAACTTAAAGGAGTTGTTGGGGTAAGGAGAGGAAAAATATGGAATACGTAAAATTTAAGGATGTAATTATAAATAGTCAATATGGTTATACTGCAACAGAGACTTCTCAAACAGAGGGAACATATAAGTACCTCAGAATTACAGATATTGTTCCTTATTACGTAAACTTTGATACAGTTCCTTTTTGCAAGATTACGGAAAAAGATGTTTCAAAATACATTGTAAAAGAGGGGGATATATTAATAGCGCGTACTGGTGCCACAACTGGATATAACTATGTAGTACCAAGTGGGATAAGTAATACTGTCTATGCTTCCTATCTAATTAGGTTTATAGTAGACAAAAAACTTGTACTCCCTTTATTTATGAAGTACGTTCTTAAGACTCAATCATATTATGGCTTTATAAATAACTATATAGGAGGTTCAGCCCAACCAGGAATGAATGCGAAAGTCTTTACGAAGTTCAATATACCTAAATTATCATTAGTAACCCAGCAGAAGATAGCCTCTATCCTCTCCTCCTATGACCGTCTTATCGAGAACAACACTCGTCGTATCCGTCTGTTAGAACAGATGGCAGAGAACCTTTATAAAGAGTGGTTCGTCCGTTTCCGATTCCCTGAACACGAGAATGTAGAAATAGTTAATGGATTGCCTAAAGGGTGGAAAACTATTCATATAAAAGAGTTAGCACAGTTAAAATCTGGATATGCTTTTAAAAGTGAATGGTTTGTAGAAGAAGGAGAAGCTGTAGCTAAAATTAAAGACATTGGGAATATCTTAATGGATACATCAAATTTTTCATATGTAGATAAAGAAAATTGTATCAAAGCTAAAAAGTTTTTATTAACTACAGGCGATTTAACAATAGCGCTAACAGGTGCAACTATTGGTAAAATAAGCATTGTACCTAAACATAAAGGCAATATTTATACAAATCAACGACTTGGAAAGTTCTTCCTTGGAGATAATCCTATGGAAAAGCTACCCTTTCTATATTGTCTTTTCAAGCAAGAATCTATGGTTTCAAATATAGTAAATCTTTCAAACTCAAGTAGTGCTCAACCAAATATAAGCCCTGAACAGATTGAAAAGATTAAGATATTAGGAAATCATGATATTATAAGTATGTATAACAAGACTTGTAATCCATTATTTTCAAACATATTAGCATTATATTCACAAAACCAACTCCTCACTCGCCAACGTGACTTACTCCTTCCACGTTTGATGAGTGGCAAACTTGAAGTTAAATCTTAATCAACCCATTGTATTATGAAATCGTTTATCAGTGAAGACGACATAGAGCAGACCCTTTGTACCCGACTATCGCAACCAGAGTTCGGATGGAAGCGTATTGAGTGTGACCCGAGTGTGGAGGCACAAGACGACGTTAGCAAGACGGGGCGTCGCAATTCGTCAGAGTGTATCTTACCTGCAGTGTTCCTTACTGCCTTAGAACGACTTAACCCACAGATTGACAAGAGCATCTTAGCGCAGGTTGTAGCCGACTTCCGTAAGGACTATACGGGTAAGGACATGATGGACACAAACTATAAGTTTTATAACTATCTGCGCAATGGTATCAATGTAAAGGTGAAGAAGAATGGCAAAGACGACTTTGACATCGTTCGGCTGATAGACTTTGATAATGTAGAGAACAACGACTTCCACTGTGTCAATCAGATGTGGATAAAGGGTAGAATTCGTTATCGTCGTCCCGATGTACTCTTGTTTGTCAATGGACTTCCAATGGTCTTCATCGAATTGAAGAACTCAACCGTAAAGATAAAGGAAGCCTATGAGAAGAATCTCGTTAGCTACCGAGAAGATATACCCAATATCTTTGCACTAAACCAGATATGCGTACTCTCAAATGGTATGCAGACGAAGTTGGGTGCGTGGAACTCTAAGTATGAATTCTTCTTCGACTGGCTAAAGGTCAACGACGAACATGAGAAACTCGACCGTGAGCATATAGCCGAGTATGGTCTTTCAATCATCAACCTCATTGACAGTCTTTTCCGCAAGGAACGCTTGTTAGACTATATCGAAAACTTTATCTTCTTTGACAATAAGCGCAAAAAGATTATCGCTAAGAACCACCAATACTTAGGCGTAAACAACCTCATGAAGAGCGTGGAATGCAGAGAAGAACTAAAAGGAAAGTTAGGTGTGTTCTGGCATACGCAGGGTTCGGGTAAGAGCTATTCGATGGTGATGTTTGTACGAAAGGTAAGACGCAAGCTAAAGGGTAACTTCACCTTCCTCGTCATTACCGACAGAGACGACCTCGACACACAGATACATAAGACCTTCGTGCGCAGTGAGGTCATTGGCGAGAAAGAAGAGTGCCAGCCAAAGAATGCAGCCCAACTACGTGAGTTCCTTAGCGGTAACAAACCGATGGTCTTTACGCTGATACATAAGTTTCAGTATGATAAGACAAAGAAATATCCCCTCCTCTCTGAGCGTAATGACATCTTTGTCTTAGTGGACGAGGCACATAGAACACAGTATAAGCAGTTGGCAGAGAACATGCACACGGGTCTGCCTAATGCCAACTACATCGCCTTTACAGGAACCCCTTTGTTAGGTTCAAAGCGATTGACCAATCAATGGTTTGGCGACTATGTATCAGAATATAACTTTGCACAAGCAATTGAAGACGGTAGTACGGTGCGCCTGTACTATAGCCGTCGAGTGCCAGAGGTGGGATTAGAGAATAACTGGCTTGACTCAGACATTGACAAGATAGTCGAAGAAGAAGAACTCAACGACAGAGAAAGAGAACTCTTAGAGAACTCCTCCTCACGTATCTTAGAGGTAATCAAGCGCGACGGACGTCTTGACCGTATTGCGCAAGACATTGCCCACCACTTCCCAAGACGAGGTTTCTTAGGAAAAGGTATGGTGGTCAGTGTGGATAAATACACGGCTGTGAAGATGTATGAGAAGGTGCAACACTACTGGGGAGAAGAGAAGAAAGCCCTCATCAAGGAGCGCAATGCAGCCAAGACCCAAGAAGAACGTGATGAGCTGACAGCACGATTAGACTATATGAATAAGGTTGAGATGGCTGTCATTATCAGTGAAGAAGCTGACGAAGTAGAGAAGTTCAAGGCACAAGGATTAGACATCACTGTTCATCGCAATAAGATGAACGAGATAACACCAGAGGGAAAAGACATTGAAGACAGATTTAAGGACAAGGATGATCCGCTAAGTTTGGTCTTTGTTTGTGCGATGTGGCTCACAGGCTTTGACGTCCCTTCGCTCTCAACCCTTTATCTTGACAAGCCGATGAAGGGACATACACTGATGCAAGCGATTGCTCGTGCCAACCGTGTGTATCCCGGTAAGAGCTGCGGTATCGTGGTTGACTATGTCAATGTATTTAAGTATATGCAGCAGGCACTGTCTGACTATGCCTCAAATGGTGAGGAAGGTGCAGAGTTCCCAGCAAAAGATATTACGCAGCTAATCGCAACCATTGACGGTTGTATTGAGGAGTGCGACTCGTTCTTACAAGGTTTAGGGATAAGGTTGGATAAGATTATCACCGATGGTGACACATTAGACAAACTGGAGTCTTTGCGATTGGCATACGACAAAATCCTTGAGAAGGACGAGAGTAAAAACAGGTTTAAGGTGATGAGTAACCTCATGATGAACCTGCATGATGCAGCAAAGCCAGAGATATTTGAACTTGGATGGAAGAATGAGAAGTTCTCTCCACTGAGTTATCTCAACGGACTGTTCTGTAACAGAATAGATGATGAGAAACTAAGAAGGGCAAAGGAGAAGATGAGCTACACACTGGACGATAGCGTTACGGTGATGGTTGCAGAAGACAAGCCACAATATAGTATTCATCAGAGTAAGGTGATTGACTTGAGTAAATTAGATATAGAAAGTATTCGTAAGTCTATCAATGCAACTCCTTATAAGTCAATGGAGATTGATAACCTACGCACCTTTATAGAAACAGCTTTGGAACAGTTGATTAATAAGAACTGTACGAGAGTGCCATTCTCTCAAAGATACAAGAATATCATTGATACCTATAATGCAGGTGGTACGGAGAATGAGGATTACTATGAGAAGTTGTTACAGCTGATTGATGAACTCAAGAAAGAGCAGGGACGGTCGGCAGATATGGGATTAAGGGAGGAAGAACTTGAAATCTACGACCTTCTTATCCAAGGTCGGAAGCTAACAAAGGAGGAAGAGAAGGAAGTTATCCTTGCTTCTAAAAACCTTTATAACAAGTTGGTGGAGGAAAAAGAAAGATTGTTGGTGGTTGACTGGTATAAAGACCCACAACCAAAGACAAAGGTGTTGGGACTGATACAACGGTCGCTGGATAAGGATTTGCCAAAGACCTATGATAGGGAGGTGTTTTCGAACAAGACAAACCTGCTGTTAGATCACTTTGTAGATATGGCTGTACAGGGGTATGGTTGGATATCATAATGGTTAGGTCTATGCCATGCCATAATGGTTGGGGCTATGCCTTCTCATTAAGATAAACGAACAGCCTACATATATCTGTACATAGATGTGCCTTGCATTCCTTTCATGAATTGATTACCTTTGCAACGGTAAAGTTCAAACCTCAATGCTCAAAGGATAAAAACTCATATCATAAAGTTCAAAGTTCAAACATCAATGTTCAAAGGATAAAAAACTCATATCATAAAGTTCAAAGTTCAAACATCAATGTTCAAAGGATAAAAGAGTTCAAAGGATAAAACTCATATCATAAAGTTCAAAGTTCAAACCTCAAAGTTCAAAGTAAAAGAAGAGTCGAACAAAAGCTGTCCGACTCTTCTTTATATTATTTATTTAAGGTGAAACCTTATTGAAGATCCTTCATTGTAAGTGGTTGAGCAAGGGTAGTAAACTCAAGACCACCTGTGGTACACTCGATACCCTTAGCAGAATCCTTAATCTTATTGCCATTTACGGTCTCTGATCCATTCAACTTGAAATAGAGTTCCAAGCCGTCAGACTTAGGATCTACACTCAGCATATTCTGCTTAATCTGATTCTCACTACGAGCAACACTCCATACACGAACCTCACTCATATAACCATAGAATGGACGTTCACCCCAAGGGAAGCCAGGGATCTTACCAATGTTGAAACCGACATCAGCGTTAGGATCGAAGCCAGAGATATTCCATGCAGACTCAGCCCACTTCGTACCATTAAGGTACATAACAGTTTTACCAGTTGCCTGATCGTAGGTCAATGCCACATGATACCACTTGTTAATCGAAAGTTTCTCTGGTGCTTCATAGTGCTGTCTACCTGCTGCCTGTAAGATACCAGAAGAAATACCACCACCAACATCACCTACGCGGAAGATCATCAGACCCTCTGAACCCATAATAGTACAGTTGCTGCCCCACCAAATAGAGTGAACCAATGCCTCATAGGTGAAGGACTTAAAGTAGGTTCCTGCTGGGAACTTCACAGAGATATACTTATTATAGAAGTCACCAGCCTTTGTAATCTTAACAGGTTTTGCTAAAATAATATACTCAACATCTTCCCCATCAATAACAGGAGTAGAACTTGAATGTAGCTTGATAGGCAACATATAGTTCTTTCCCTCTGCTAACTGGTCGAGATTGTTAAGCGTCAACGACACCTTATCAGCATAGATACTTCCAGCTGCAATCGTTGAAGAAGCCTTACTGAACGTAACATTCTGATGCTTTAAAGCAACGTAGTCTGTTCCGTACTTGCTATTATAAAGAGCAACCAATGATGAGTCGGCAAGTGAATAAGAGACATCTACTGCCCCATCTTGCTTGTTAGAAAGGCGAGAAGTAATGTCGACACCTAAGGTTGAACCAGAGTCAGGCATTTCGACTTTGTATAGATTGCTATCAAAATAAACTTTCTGCTTCAACAAATCGCTCTCGCTGTCTTGGCAACTCACCACACAGCATGCGGCAAACGCCACAGCAATATGTTTGAAAATATGCTTGTTCATATTTGTATTCTATTAAATTTATAATGTGAGATATGCAATGTTAAGGTTGAGTGGTCTGCCCCATTCTCTCCTTGAACACCTGTTGGTTAATCTGAATTGCCTGACGCATCCACTTGTAGTTAGGAGTATTGTCGTAGTCGTTATCGAAACGATAAGCACCTACTCCACCCTTGTAACCCTTAGAAGGCATACTCTTGGCTTGTCTTAACAGCTGACCACCACTCTTGAAAGAAGACTCAAAGTTATCGGTTGTAATAATTGTCTTTGGATCAACACCGTAGTAATCGAAGTGAGTTGTACGACCGTAAGCCTGATCAATCCAGTAATCAACATATCCATCCAAATCCTCAGTAAGTCCACCAAAGTGGCCATCAATACAGATAAGACGGTGGCCCTTGTGCTCTGGATCACTCTTAGGACCGATGTACTTGTTCATCTCCTTTACCAAGTAAACGAGGTCGGCATTGGTACTGAGTGTACCATCCATATCGAAGACACCACTACCAATCTCCCAGTCGATATCGTAACCGTCCCAGTCATTGGCTACCAATGAGTCGCAGAGAGCCTTTGCAAAACGAGCCAAAGCCTCTTTGTGGTTATCAGAACCAGCAACACCCTCGTAGCCCCAGAACTTCCAACGAGCCTTCTTCTTAGCCTCTTCAACGCGAGCTTGGTCGTTTGCCCAACCCTCTTTTTCAGCCTGCTTCTCAACAGCAGTATAGACAGAGTCAGGAGTTCTACCCTTACCAATGTAAGACAAGAGTGTAACTTCCAAGAGTTTTGTACCCTTCACCTTCTGCACAAACTCCTTGTCCTTCTTCTGCTCAGGTGTAATATTAAAGCGGTTAGGTGCACCACTCCACATGGAAACGACGTCCATACTATCTGGCATAGAGGTAAGATAGCCACGGCGATAGGTACCTGCTGGCGACCAGTTAGAATACCAACCAAAAGCAACAGGACGACCATAGTTAACGGCTTGCTGCTTATAAGCTCTCAAATCGGCATAATACTTCTCGCTCTCAGCATTGTTCATCGTATTATATCCACCGATATGATCGTAAGGTTCGTTCTCTACCTCTGTCATCTTGCTACATCCACAGAAAAGGACTCCTGCACAGAGCAATACCAACGAACTGATATATTTAAAGTTTTTCATATTCAAAATGCTTGATATTAATGATTCTTATTGTCCCACCACAAACGTGTACCAGCCTTATCCAGACCGCCACGAAGTAGCTTGCGTGCACTCTCTAAGTTAGCAATATCCTCTGCCGATGTAGACTTATTAGTTGGGAAACGCATACGGCGGATGCCTACCTCGCTATCAATCTCACCGTTGCTATAGTTTGTAACCACACTATGCAACTTAGGATAACCTGTACGACGATACTCTGTCCAAGCCTCTTGTCCGTTAGGATAGAGTGCAATCCACTTCTGTATCATAATCTTCTCAAGTTTCTCCTCATCGGTTCCACTCCATGCCGTAGTAGCCTCTGTTACTGCTGGTACGTCAACATTCACACCTGGATTGGTGAGATGAAAACTGTAAGCAGATGGCTTGAGACCAGACGACATATAGTCTGCTACCTCAGAACTTGCAATACCATTCTCTTCAAATGACATCTCGATACCCTTCTCATAAAGTGACTCAGCAGTGCCACCCACAGCGAATCCATGCAGAGCAGCCTCAGCCAAGAGGAAATAAACCTCAGAAGCACGCATCCAATAAGTTGGAGTTGTACTTGTGATAGCTGGGCGTGAAGAATCCCTGAAAGCATCGTTAGAGCTTACGTCATGACCTGTTGGTACACCAGAATACTTTCCGTATGTGCCCACAGTCACTGCCTGAGAAACAGTACTTGTATTGAAGTACTTTGGCAAACGTGGGTCTTGATAACCGCCTAAGTAAGCCAACATAGAAGAACCCATACGGCACTCGTTATACTGATTGATAAGAACATCGAGGTTGTTCTTGAACTCCAAGCTTGCGCCTCTCTCCATCTTAGCCTCATCATCCTTGGTCTTCATCACGCCATAAGAATGATTGACAGCCTGTAAAGCATACTTCTTTGAGAGTGCAGCATCAGCATAATAAACACGCATAGCAAGACGTAACATCAAAGAGTTAGCATAGACAACCCACTTGTGAACGTCGCCTGCATAGACAGCATCAGCATTTGGCAAGAGTTTGCTATTACCATTATCAGCGTACTTTGTCAACACTTCTATAGCATCAGAGAGTTCTTTGAACATTGCCTTATACACTTCTTCCTGACTATCGTATGGCACAGTGATGAGTCCTTTACCTGCCTCCTTATAAGGGATAGGTCCGAACATATCGGTAGCCTTATGCCAAGCAGAGATCTTTAGAATCTGTGCTAAGGCGAAAACCTCTGGGAACTGAGTCTCAGTCTTACCCTTTAAGTCTTGCCACAAAGGTACAACCGTTGAGTAAGACTCGGTGTAAGACGATGCTACCCAACCATCCTTGAGGAAATAGTTGAGGTTATTAGGACCGCCCCAGTTATTGTTCTGACCGAAATAACCACTCCAACAATCTGCTGCAAGGTTATAGGCTGTTTGATATCTATTAGCAACACTGGTACCATCTGCCTGTGTTCCTACTGGGAAGACGCATTTCTGCATGGCAGTTATAGGACCACCAATAGAAATACCATCCATCAATCCCTCCTCTGGGAGGAGTTCAAATTCGTTAGTGTTTACCTTTTGGAAGTCACAAGCCGTAAACAAGGACAGCGCAAGGACACCTACGATATATTTATATGCTTTTGTCTTCATGTTCAATTAGAATTTGAATTTAACACTGAAACCATAACTCTTCAGACTTGGCTGCATGAAATAATCATTGCCCTGTCCGTATGTACCTGTTGAAGCAGTAAGCTCTGGATCGAAAGGTGCTTTACAATAAATCATCCATGGATTTGTAGCCACAAATGAAAGTGTCAAATCCTTAATGACATTATTAAACAGCTTTGAATTAAACTTATAGCTCAAAGTAAGTTCCTGCAAACGAACGTTTGTTGCGCTGTAGGTATAGTAACCTGCGAGGTCGTTCTCACCTGTAGCAACAAGTGTATAATACTTCTTTGCATCATACAAGCCCTGATTTGGAATCATCACGCCACCAGCATCTCTTGCATCAGCTGATGCCTTAGACACACCGAAGCGGTCTAATAATGCCTGTGTTGAAGAAGTAACAATACCGCCAACACGTGCATTAATCAAGAAACTAAGCCCGAAGTTCTTGTAAGTGAAGTTGTTGTTCCAACCCATTGTGAAGTCTGGGGTAGTCTTACCTAAGTAGATAGGCTCAACAGTCTCTAAGTTCATACCACCTGATGGACTAACATTTACAAAGCCTTGATTGTCCTTTGCCAATACCTTTCTTGCATAAATATCATTGATAGAACCGCCCACCTTAAGCAGAACACGGCCATTATCCTTTGATACTTCAGGGATATTGATCGGCTTTGGACTCAATGGGTGATGGTAGTCCTTCACCATCTCCTTAATCTCATTGACGTTCTTAGAGTAAACCAATGATGAGTTCCATTGCAAACCACCAAAGTTATCGCTATAGCCTAATGCCATCTCGACACCACGGTTCTCTACATTACCTGCCTGCAAGTAAACAGCCTTGTAACCAGAGCTCTCTGGCAACTCACCGATAAATGTCTGATTGTAAGTATTAGACTTGTACCAAGTGAAGTCGAATGATAACTTCTTCCAGAAACGAGCAGTCAAACCGAACTCGTATGACTTTGTACGCTCTGCCTTATAATCAGTAAATGGATAGATATCAGTAGATTTCAAGCTACCACCCACGATTGGAGTTGTAATAGTACCTGGTGTCATACCTGAACGTGAAACAGGAGAACCAACCTCAGTGTAAGAACCACGAACCTTCAAATAAGAAATGAATGAAGGGAGTTTTGTCATCTCTGAGATAATACCAGATAAACCAACTGATGGATAGAAGAATGATTCCTCAGATGAGTTTACAAGACGTGAGTTCCAATCGTTACGACCTGTCAAAGTAAGATAAACCATACTTCTCCAACCCAATTCGGCACTTGCAAAAGCAGCAACGTTACGTACCTTTGAGTCACCACCAGCCTCACGAATCTTGCTATCAGTTGGATTTATGTTATTCAAAGAGAACTTATTTGGAACTAACACTAAGTTACCACCATAACCACGGGTGAGAGATGCATAGTCAGAATAGCTATAACCAACGTTGGCAGCAAGACTGAACTTACCAAAGGTTTTATTAATATTGGCAATAGCGTCAATATAAGTCTGATGATCCTTATAATCATAGTAATCATAAGCGCCCTTCTCCTTGGCAAAGTAATTGAATGAAGAAGCATAAATCTTACGCTCACTTGTGATAAACGTCTTGTCGAGACGAATACGACCTGCTACACTCAACCAATCAAAGATATTATAAGTAAGACCAGCATTGAACATGAAGCGATCCTTATCGTCTGGTGCTAAGTTACGATAAGCCGTCCAATAAGGGTTCTGATTAGCAAAACGGCTATCACTGATTGGCCAATACTGAGTTGGGAAGTTTCTCACGTTATCGTAACGCTCAAAGGTCTTGATTCCCTCAAATGACTCACCGCGTGGGAAGAGATAAGCTGCGACGATTGGGTTCCAGTACTCACCCTGTGACACCATGTTATTGTCTTTCTGCTTGATATAAGATGCACCAAGGTCGAGTTGCACCCTATTCTTAAACATACGCGTAGTGTTACGGATGGTGAAGTTGTAACGATCGTAAGTATTATTTGGTACGATACCACGTGAATTGGTGGTTGCTACAGAGGCAAAAGTCTGATTAAACTCATTACCCATATTCAATGTCAAAGCATTGATGAAGTTCGTTCCTGTACGGAAAAAGTCCTTCTTGGGATCGTATGAACTTGGTGTTGCGAGTTTCTCACCCCAACTCTCATAAGAACCAAGCTTGTTGCCATACGTATTCTGAAACTTTGGCATCAACAATGGTGAGCTAAAGTCTGCAGAACTTGAGAAAGAAATGTCTACACGTCCTTCTTTACCCTTCTTTGTGGTGATGAGGATAGCACCATTAGCAGCATTACTACCATAGAGGGCTGCAGCAGAAGGACCAGCCAAGACGCTAATGCTCTCGATATCCTCTGGGTTGAGGTCGGCAATACCTTCACTGCTTACACGGCCTTCTCCCATGATACCGCTATCGCGTCCACCACTGAAATTGAAGATTGGAATACCATCAATAACATACAATACGTTGTTATCACCTTCGATAGACTTGGCACCACGCATGATTACACGTGTTGCACCACCGACACCACTGGCACTCTTAGAAATGCTAACACCAGCTACTTTTCCGTTTAATGAGTTCACAAAGTTAGCATCTTTGTTACGTGTCAACTCATTTGAGCCTACTGACTGTACATTGTAACTCAAAGCTTTCTCAGCACGTTTAATACCCAAGGCTGTCACAACAACCTCATTCATTGTGTTTGCAACTTCTTTAAGCGTAACATCGATGGTGGTTTTGTCGCCCACAGGGATTGTCTGGGTAGTATAGCCAACATAAGAGATAACCAACTTTGCCTTTGACGTGGTATTGATAGTAAAGTTACCATCAATATCCGTTACAGCACCTTCTTTGGTTCCTTCCACCATAATAGTGGCACCAATCAGTGGCTCACCAGCAGAGTCAACAACGCGACCAGTTACCTTGTGATTGCCGTTTTGTTGCACAGCCTGAGGCATAGAAGCATCAGGTGAGCCTACGGGATTTCCTACTGCATAAACACTCGTTGGAGCTAACGCAATAGAAAGGGCAAAAGCGACTGAGAAATACAGATGCTTCTGCTTTGTTTCATGAATCATTCTCATTAGGTTCAGGGTTTAAATATTTATATTTTAGGTTCCTAATTGTTACTTATTAATAACAGCTGCATGAACAACTGCATTACAACACTATCACCTTATTATAGTAAGGTAATGATGAATAAAGAAACATTTTTTATTTACACAGGTTGTTTAACGTATAAACGTAAAGATTATTAATGAATAATAGGTTAGGTCAATTAACTCATAATAACGAGTGCAAAAGTATAAAATAAATTTGTAAACAGCCCTCCTTTTTATAAAAAAAAGTAAATAATATATTTGTTATTGCAAAAAATAGAGATATACGCCAACACGTATATCTCTATTTTTTTTATATATAAACACGTAAATGCCGTTTACCCGTTCTTTACATCAACTATCTTTGTTGGAGCCTGTTCCTTATTGCGACGATTGACAACAGTGACTACACTCTGCGCAAGACTGAGAAACGACTGACCTGTAATGGTGTCAACCTGTGACGCTGCTGGTGTTCCGTTATCACCATTCTCGCAAATACTCTGTACAATTGGAATCTGAGCAAGTAGCGGACATCCAAGTTCTTTTGCTAAGTTCTTGCAACCATCTTTTCCAAAAATGTAATATTTATTCTCAGGAAGTTCAGCTGGAGTAAACCATGCCATATTCTCAACCAAACCGAGAATTGGGATATTCACCTTGTCATTACGATACATATCAATACCCTTACGTGCATCTGCCAATGCAACATTCTGAGGAGTTGACACGATTACTGCACCCGTAATAGCAAGTGTCTGCATGAGTGTCAGGTGAATATCGCTGGTTCCTGGTGGTGTATCGAGGATAAAGTAATCGAGTTCGCCCCAATCAGCATCAGCAATAAGCTGCTTAAGAGCTGAGGTTGCCATACTTCCTCGCCAAAGGGTTGCTGTGTCTGGATTGACAAAGAAACCGATAGAAAGCAACTTCACACCATACTTCTCCACAGGTTCGATAAGCTGGCGTCCATCCTTTTCTACTCCGTATGGACGAGCATCTTCTACACCGAACATCTTTGGCATACTTGGACCGAAGATATCGGTATCGAGCAAACCTACCTTATAACCAAGGCGTGCCAAGGCTATAGCGAGGTTAGCTGAGACGGTGCTCTTTCCTACTCCACCCTTTCCTGAACTAACAGCAATGATATTCTTCACCTGAGGCAACAACTTACCCACCTCTGGGCGTGGCGCATTCTTAAACTCTGTTGTAATGGTTACTTCAACTTCCTTACCAACAGAATAGTGAATCTGAGCCTCAGCAGCCTTAATAGTAGACTTGAGGAATGGGTCGGTCTCACGTGGGAAAATAAGCGTGAAACTTACTTTATTACCATTGATGCTGGGTGTATCTGCCAACATCTCACTTTCAATAATATTCTTTTTCGTTCCTGGATAAATTACTTTCTCCAGTGCATCTGTAATGAGTTTCGGATATAATGTCATTGTTTTATTATTTTATAATCTTTGGAGAATGAAGCTATCTCACTGCTATAAAAGCTTATATTCCTTCTTATTAGAATTTCACTTACTTCTTTAAGTTAACAAAAAGAATGCCACAAAATAATCGGACACATTAGTTACCGTTATTTTGCGAGTTCTCCCATTCTTCCCATTCCTTTGCAACAGCTTTCCAGTCGGTCATCTCTCCCGCTTCAATGGCTTGCTGCTCACGTGTAGCCTCATCACGCGCCTTATCACGCGCACGCTTTGCCTTCATATCAGCGATAGTGGCATCATCAAGAATCTGAATAGCTCCTCGTTGGATAGCACCCTGTAACTCCTCTTCACCGAAAGCCTTACCGGGCTCATTGAAGTCAGAGATATTAAATTCATAAATTGTACGGAGGTCATGACGAACCAATTTCTGTTTCGCCCGATTACCCGCATTCTTCAGTCGGAGTAGCTTTGCTATTTCTTTTATCTCGTCTTCTGCGAATTTATTTCTTCCCATGTTTTGATTCTTATTCAGATGCCATTGATGGCTTTCGTGTCTGCGAAGATAGCAACAAAATCCCAATACTGCAAGTTTTTTCTTAAGGAATACATTACGTAAAGTATGATAAATTGGCTTCATTCGTTAAACCTAAATCTGTCATTAGTCCACAAAATGTATAGTTTTTATTACTATGGTATTGTTTCCTAACATCTTTTATTTTTTCGGTATCGCCGCTCTTTGTATCTTTGATACCTCCATGATATGGTTCTTCCGAAATATGGAGTGATAAACTAAAAGTCTTATATTATAAGGCACACAGAGTCACGGAGAGGACGGAGGTAACGCAATGGCACGGAGGTGTAGCATACAGATTCTTGATAACTATTCTGGGATAAACGCTTTGTATATAAATTGCTAATAGAATTGGCTAACAAGCTCCGTCGCTCTATGCCCGACGGTGCCTCCGTGACTTCCATTGCTTTGTTTTAATAATCCTCCGTCCTCTCCGTGTCTCCGTGTGACATTTCTTCAGAAACCTAACCTTAAATAACAAACCTTATCACTCCAAAATCCAGAAGAACCCATGATATTACGTTTACCTCTGTCTCTCTATGTCTCCGTGTGCCTTATTAGATAAGAACTTTAGCCTATTATTCTATCTTAGGAAGCGACCTCTTTTTACACAACCCACCTATATTTGTAAAATTGTTTCAAACGCTTAATTATCAATACATACTCTTTAAGCTTCTTAAAGATGCCTAATTAGCTTCCAATAGGTGCCCTTTAGAAGGCTTACTAACGCCCTTTTGAAGTCCAATTAAGCATCTTTTAAAACACTTCATTATAACAAACTGACTTACTGACAGTTACAAACCATCTGGTTATACTTATTTTTCTCCTTTATTTTAAGGCTCTTATTCAAAAACATGTAAGTATTTTTCGCAAACCAATACACGCCCAACAACCTACTCTTTTCAAGGTATCAACTCATTAAGTTACAAACAATGTTATAGATTGGCTGCCCGATAGTTGACATGGTAGGTTTTCCTTTCTATTGATTCCTTGGCACTATCCACAACTATCTCCGCATGAAAAACACTTTTGGGCAGCAATAAACAGGGACGTCAGAGCGTTATTGTTGACAGAATAGGTTACGACAAAAGACGGTCATACGACCTATACGAAGCTTGGTAATGGCACCGAGACTACCTATACATATGACGAGCAGCGTGAACGTCTGCAGGTGATGAACCTTACAGCAGGCGGTCAGACTGCAATGGAGAACTGATATTAATCCAGAGTAGATTAGCATAATTCTCAAAAAATAGTAGTAATAAAGAAAACAGATAAGAAATTATGAGGCAGGCTATATCGATTATTGTCCTATATGCTTTGATAAATATTCTATCATTGTTATTCAATATAATTTCTTTTTCTACTGATGGGAAGATAGATATTGGCTTCCCTTTTATTTTTATCCATTTAACGAGTGCAAAGTATGATCCTACTTTTCCATACAATAAATTACTCATAGAGCCTTTTTTATGGGATATTATTTTTTTATTTACGATAGTTTGTTTATATTTGTGCTGCCTAAAATTTATCAAAAGGATTCGTGATTGAGAAAACCTAAGAATGAAAAATAAATGATGACCTACGATGCGGTGAGCAACCTCACGGCATAGTTGAGAAAGTCTATCGCTAAGAAGGAGTTTGCATACGCATGAGTATGATAATTTGAACACCCTTATCCATGCAAACGGTAAGGCGAACTGTTATACATCCAACACTGCTGGCGAACGCATCATGAAGAAATGCAAATATTAGGAGATAAATATGAGTTGCAGGCATAGAGAAAGCCAGATGTCTTCTTCCCTGCATTTACTGAGCTTAAACAAACGATTTATGATTATAGCACATCGACTGACAAAGAACATCATGATTTAATACAAAAGTACCCTAATTTACAGGGAACTAAGTTGTATAGAGCAATTAAATCCGAGTTAATTGAACAAAACAGTAATTAAAAAAACATTTGATCATGATTTTAAGGAATACAAAAAGAATTATTAATTATTGTGTGTTGATGATAGGGCTTGGCGTATGGGGATCATGTAACTCTAAATCACAACATGTTTTACTCCCTGTAGATAATGTCAAATCTTATAAAATATGTGAGAATAATGACACAACAACAATTTTCGAAGAAAGAGAAGAAGAGTCTGAAGAAGTAATTAAATTTTATAAAGAGGGCAGTGAAATTTTTACTTCCGACTATGGTGGACGCAAAGAATTACTGATGTCCACAACAGAGATGCTGGATACTGTATATTCAGGAAACACTTATTGTAGGGAGCATCGAATTCTGATAAAAAAAGAAAATTCCAATCTGTTTTCTACATCTATATATAATATTATTATACACCCTGTATTGGTCTTAACGATTTATTATGACCATTCATATAATATAAAAGCTATTCGTAATTGGTTTGCATTTACGACTTATGAATCGGAACACATTAGTATCCCGCTAATATCGAGACCAGTTAAATATTAATCAAATAACCCCGGAAAGAGAGGACAATCGAGTTCTCTCTTGCAAAAGACTGTAGTTCAATTAATTCAAAGAGCTATTAGTCCTCTTTAACGGGACAGTAGTAATCGGAACATGAAGAAAAAGAGCTCTTTTGACAATGGACTCAGACTCCGCATCCTAACACGACACCAGGCACCAGCCTTGGGTGCGCCACTCTCCATATTATCTACTGGAAAGATGGATGTAAGACAAGGTGTAAATTTGAAACTATCTGGTGTAGAACGGAAATGCCGATTGCATACTGTTTTCGATTTTGCTGTCATTCCTGTCACTTCACTTTTGACATTAACCTACTATCTATAAACCCATTACACGAAGTGTTAAAAGTGACAGCAACTAAAAATAAAACTAAATTAGAGGTTTTACCCAATTCGGTCATTAGAGCCTAAACATTTTTGGTTTTAGTATCGAGTAGATTGTTTGGCTTTGGAACGCAGGCGTAGCGGGCTACGTCAAGTTACAAAGACAGACAAAATGTCGATAAAAAAGATGTTAGGAAACAATACCATACTATCGTAAGAATGTACATATTGTAGTCTAATGATCGATTTAGGTTAAATGATTCCCTCTTGGTTACATTTACACATACAATACCCTCCATCTTTTCTCCTTTTCCCATGTTTTTAAGACCCTTTTACAAAATAAAGTTGTATATTTGCCTTTGAAATTGCTATGCTCGATATGACTGTTCTTTCCAAAAAGAGACTAATCCTGAAAAGTATAGCCACAACATAACACATAACAAAGGACGTCTGCAGGCACAAGACCTCACAGTGGATGTCGGGTTGTGGTGTAGGAAAACTTCTCCTCAATGCTGTAATGAACGGCAAAGAAGGGGAATAATGTCCCTGCCTAACATACATTTCCTACCCACACATTATTCCTATTCTCACCACTGAATTCCGATACCGTCTCTTACAGACAGTTCAAAAAAGCATCAACCAACGTTTAAAATGAAAATAAAGAATATTTTAGCTGTTTTTATAATAGTAGGCGGCATATCTTATGCTCTTTACTTTTCATTAGTTACAGATGTTTTATTAAAGTATGGTGAAACAATTCACACAAAGGCTATTATTGAAGAGAGATTAACAGGAAAGACTTCCGATCCAGTGCTGCGCTATAGATTCTTATATGAAAATCAAGCTTATATCGGTTTTGTGTCAGAAACATCACGTTTACATGTGTCTGATACTATTAATATTGTATTCTTAAAAAGTAGACCGTCTATAAACAAACCATTAATAAAATAAATTTTATATGAAAAAGAACTTGTTATTCTCATTTGATGATGAGATTACGACTGGGGTTTATTATGACATTGATGGTCATAAAATTGTAGTTTATTTTGCGGCTTATTATGATAATGGGAGGTTCGTAGAGAAGAAATGCCAACTTATTATTGAGAAATGGGAGTATGCAAAAAGTAAATTATCAGTGGATAACCGATATAAAGATTTAGAAGATCATATTGGAATTATAAGTATGATTTTAGATATGCATATTGCAGATAAAAAATTGTTTTTAACGGTGAATACATTAGATGGTCAATATGTGGATTTACTGTTTTATAATTGCAATGTTAAAATAGAAGATATTTCTTAAGTAGGACTTGTATAATACAAAATGTGACCTTATGAATTTAAAAATAAAACCGACTCATAGTACCCTTTTGAAAAAGATAAGATGACACCTTCAAGGTTTCTTATGGTTATACAACTTATAAAAGGTTTACTTCTAATGGCAAAAGATTTTAATATATATACATATCCTACCTTTTTTTCATTGTTACTGATAATGCTAATACCATTTGCATTATCAGTAGATGATATTATGAATAATCACCAAAGCAATATGAAAATAATACTTTGGATTTCAGTATTTATAATCATCATTCTTGTTTATGGATTAATAAAAACTCGCAAAAGAAAAATAGTCATAAATGAGTTAGGCTTACTAATTACAGAAAAGGAAGGAAATATAAAGATTCCATGGGAGGATATATCGCACATATTTTTTTGTTCAACACCAATTTGGGGGCTATATGTAAAAATAACTTTTACTAATCGAAGGAATCCTTTAATTATTGACTTTGGGAAAAGCAGTTTGTGGAGTGTCAATTTTTATCGTTTTCGGATAGCCATATTGGCGTTTTCACATAAAAAGGATATAATAGTTGTAAAATCCAATCAATGGTATCTAAAGCTAATATAAAAATAAATACACAGATAGAGAAAAGGCCACATGTCTATATTTGGCAACAGCAAGACAAGCTGCTACACCTATAACACAGGTGGTCAGTGCATCATGAAGTGTTATGGTACGATGGAGGGTGTCTTTACCAATGGAGCATCATAGGGTATTGCCTTCTAAGAGTAACAAGAAGAGGTATGAAGGCGATTCTCGTTATAGAACAATAATAATCATTCAAGAAATGAAAAAGAAACTCATTTTTATTCAGCTCTGTATTGTATTGATTTTATTTTGTATAAATGTAAAAGGGCAGAATGCTTCTCTAAACAAAGCATTGGAAATCTCATACTATAATTTCTTAAGAACAGTACCTGACAGGTGGAAAGATAAATTTGACAGAAAAGATTTCTATCTCGTCAATAATTATAATCCATATGGTTTTAATGTTCAAAGAATAAAGGGCTGGAATAATTTACACCTTAAGAACGGTAAACTTATAATAGGAAAGAATCTTGTAGGATATCCGCTTTTACAAATGATAGGCAGGGATACACTGCTAATAGAGATAGGGCAGATCTTTTGCAGACAAGATAAAATGTGGGCTTTTACAGACGGATATACATCACTCTTTAATGTGGATAATAAAACTTTTAAGGCAATAAAAATCTCTCAGAAAGACTTATATTACAAGCCTGATAATGCTAAGAAGCAAGGAAAACTTATAGACTTTGACAGTATTTATGATAAGGCCGTTAATAGAGCGATTGGCTATTTGGAAAGATCAGGAGTCCCTCGGCATTTAATATATATAAATAAGGAATATTTTCCAAGTTGGTTTTTCAAAAACCAACAAGAGAATGTCATTGAAGGTTCTGAATATAAAAAATACATCAAAAAGAATTATTACGTTATCGGTTGGCCTATTTTATTTATAAAAAAAGGGAATATAATCGTCAGGTTGCATTGTTCATACAAATCTGGTATAAGAAAGAAAATTATTTCAGAAGTCCAATATACATTTGACGAAAAGAAAAATAAATGGACACTTCATAATGAAAATTCCACTACTATGTCTATTAAAATGAAATTAGTTGATGAGCATAGTAGCAGTGAGGACCTGCCATATAAGTTCAATGGCAAACAGGTCGATGAGAAAACAGGTCTGTACTATTATGGTGCAAGATAACACCTTCAATGTTTTCTTACGTTAAACAATTTATAAAAGGTTTACTTCTAATGGCAAAAGATTTTAATATACAGACATATCCTACATTCTTCTTATTGTTATTGATAATGTTAATACCATTCGCATTATCAGTAGATGATATTATGAATAATGATCAAAGCAATATGAAAATAATACTTTTGATTTCAGTATTTATAATCATCATTCTGGTTTATGGATTAGTAAAAACTCGCAAAAGAAAAATAGTCATAAATGAGTTGGGCTTACTAATTACAGAAAAGGAAGGAAATATGAAGATTTCATGGGAGGAGATATCGCACATATTTTTTTGTTCAACACCAATTTGGGGGCTATATGTAAAAATAACTTTTACTAATCGAAGGGATCCTTTAATTATTGACTTTGGGAAAAGCAGTTTGTGGAGTGTCAATTTTTATCGTTTTCGGATAGCCATATTAGCGTTTTCACATAAAAAGGATATAATCGTTGTAAAATCTAATCAATGGTATCTAAAACTAATATAAAAATAGGTAGTTCAATTGTTGTTCAAGGTGCTTCGTTAAAAGCTAATAAAATAATTTGGTTTGGCTTTACAACATTGTAACTTTACATCTGATGGTCAATAGCTACACGAAAACAAAGGATTACAACCATGAAACCATTTAGTGTTCAAACGGCAGAGAAACATCTTATCAATATAATTTATTCGGTCGAAAGCTTATATTCTTTTAGAGAATCATGGTTAGGATAAGGAGGAGTAAAACATTTAATTTAAAAAAGTAAGCTATGTTAGAATATAAAAGATATCAAATTTTGAACCTAAATTTTATTAATGAACTTGATACTGTCATTTTAGATTCAAAGCTTAAATATATTTCTGATTTTATTTTCCGTCAAGTACAAGGAAAATCTGTTTTCCTTTTTGAGATGAAGCCAACGAAGACATCAATTCTCTATGATATAGACCCAGAAAGCAAATATCATAGTATTAACTCAAGAAAAATAATTTATACTAAGAATTTAAATCTAAGCAAAAAGGTAATTTCTATGATAGTTGAAGATGAAAGCTTCTATTTGGGACATCTTTTAATTATTATAGGGACTTTCTCAAAAAGTAAGATTTCTAATATTTCAAACATGTGGGAAAATTTATTAGAAACAGGAATAGAGTATTTTAAGATGGGAAATGATGGAGAATCTTTTTATTGGTGCAACCCTCAGATAAATTCAGCAGAGGAAGAGTTCAAATTATTTATTAATGAATTGAACACCTTTGCCAATGGTATCAAACATATTAATAATGAAAACGGATAAGAATATTATTGGGGTTATAGCATTACATGTAATAACTTTTACATTTGTTATAATTTCGTGGAATCATTCATTTAATAGCATAGGTTTTAATATAGTCTCTGGTATTTCATGTATGTTATTGGGAGGCAGTTATTTACATCTCGAATTATCGAAATATTCTGAAGAAGGGAAGGTGACATGGTTCAGTATTACGCATACGATTATACCTTTAATCTTCTTGTTATTCTGGGCTGGTATTGCTCTTATATTTTATCATTATATCGTAATAATGTCTTTATTACAATGTCTGGTCACAAGTTTAATTCCCCTCAGTTTTTTGTACCTTAGGAGTAAGCGTAAAGAAAATAAATATATAACGCTATTACTCATAATTATAAGCGGCATCTTCATAGTTCTACCCTTTATAGTTTTATCTATTTTGTAACTATTCAGCGGTATCGATCAGTCTGTATTCTCTCTTCTAAAATCTTCGTATAAAGACTATAAAGATGCTTATTTTTCTTGCGTATTTCAGATTTTCTTTGTACCTTTATACCTATGAAAGAGCAAGTTACGGACATATCAAAAGTATTACAAGGCATAACGGAAGATATGCGATTGTTGCGTGAAACTATCAATCAGCAGTATACTGAGATTATCAAATCGAACCGTAACATAAATGCTCTGAACCTTGAAATTCGCAAGAAAGATACGAAACTTATAAACTTACGGAGTGTGCTTGATTATGTGACGCAGGTTATTTCCATTCCAGAGTTGAAGCCCGTAATCAAGGAAATCCGACACTATGTGATGATATGCAAGAACTGTGGTGAACGTATTCGGACGGTACTGAGACGGCGGTCAAACAACGTGGTATATGATTCAAGCGTAAAGACCTTAGTGGTTTATCTGAGTGTCGTTCAATTTCTTCCTTACGGGTCGCATAGCAAGTTTTTTGCGTGAGGTATTTGGACTCACTCCAAGCGAAGGTTCGCTGGTGAACTGGGTAAATGAGGCTAAGAGAAATGCGCAACCTGTGATTGATAAGATTAAAGAATATATCAAGTCATCAGCAGTTGTTGGTTTCGATAAGAGCGGCTTGTACTGTAACAAAAGACTCGACTGGGCATGGATTGCACAGACTGTTTATTACACATTGCTTTTCCGTGCTGATGGAAGAGGATCGAAGGTATTAGCAGACAAATTTGGCGATAGCTTGGAACGAATGACTGCCGTTACCGACCGCCATAGCGCATACTTTGCACTCCATTTTGGGACTTGCAGCCCTAAATGCCTTAACTTTAGCATTGAATGACTCGGCATTTGCATTCGTAGCTCTGTTTACAAAGAAATTGAGTATGGTTTGATAATGATTTTCAAACGTGTCAATCACCGTGTAGAAATTGTCCACTCCTAACTCTTTAACCTCATTAAACCATTTAGCCAGCTTCAGCCTTGCAGCATCCTTGATGCTCTTGATGTTATAAATATCGGTAAGTTTCATAGCCAAATCATATGCCTTTTTCAGTGTCGGATAATGTTCAAAGATGATTTGTGCCCTACCTTTCTGTGTTTCAGTCCACTTGGTCTTGTGCTTGGTCAATATGAACTTTGCTCTGGCGAGCAACTGCTTACGCGTGTCACCATTGCTGTATCTAAAGGGTATATATTCCTTACCCTTACTTTTAGCTTCTTTTATCTCCTCATTCTCTTTATCTCTTGCCATCCATCGGTAAGCGATACGCATGTCATCCAGAGCATCATAATATAGTTTCTGCACATGAAATCTATCATTGGTAATAAGCGCTTTGGGAAAAACAGAGTGGGCTATGCGCATCATAGAAGATGACAAATCGAGTGTTATCTCCTTGACAGTCTTCCGTTTAGAAAGGTTTATCTTCTTGAGAACCTGAATAACGTCCTCTGCCTTGGTCCCTTTAACCACAGCTACCAAAGTCCCTTTTCTGCCCTTCCCCGCCTTGTTGGTCAGAAAAGTATAAACCTCGCCACTGCTTAGACAGGTTTCATCAATACTTAGACTCTCACCTATGTTATCTTCAAACAATAGCCAGTCTTGAGCATGTCCCAACTGATCCCAGCTACGGTAATCACTGAAATACTCCTTGTACTGTGTGGATAACAGCTTGCCATTTACGCCATAGTGAGCACCGATACTTGCGATGCTCTCTGCGGTGGACTCTATTCTATTCTTTTAAAAAAGAAACGAACTCGGGGGATAGTCTACTGCCCTCAGCCGTCAAGTCATCATATGAATAAGTAAATATCTCTCCGTTGGAACTGTCACGCCACTTGCGACGGCGAACATGGAGGTAAACTGCTTTGCCACGAAGGGGGAAGTCCTGAATAACACGCTCGCTGGTAAAACCATAACTGCTTACAGTGCCTAACTTATGGTCTGACTTTTCCATAAAGTTACGCTCGTCAAGCCAAAAGTCAATCTGCGAAACACTCTCTTGAATATCGACAACATCAAAGTAGTCGGCAAGTACATCTGGAAAGATACAACGTAATAATTGGTGATTCTTCATGATGCAAAGGTAATAAATACTTATGAAAATATGTGCTTAAGAGTATAGACTTGCAACTGGGTTTTGGGACTGACCCGTATTTACTCCCTCTGTACGTACTCAGAGAAGAAGAATGTATATAAAAAAGAGGGTGTGTCAAAATTGATACATCCTCTTTTTATTCTTCCTTTACCTTGTCTACCACATAATTCGTTATTTACTGCAGCTATGCTGCTAATTTCATATAAAATGATTTATTGGGCTTTAAATAACCTATATAAACTTGTATAAAGTATCTGAAGGTGACTAAAAGTAGCTCCATAACGGCTTTTAGTTCCTTGAGATTGGTTTTTCTACACATTTTCCCTATGTTAAAGGCAATAGCGAAGAAGGCAAAGTCCATATTGACCTTGTCTTTCCCAAAATGCCTAAACCTCTTGTAGGCTTTATTATATTTTGTTTGTCCAAAAACAGCTTCAGGTTCTATGCACCTTCGTCCTCGATGCTTGATGCCTTCTTCCGAGGTCAGTAGTTCCCGTGCCTTTTGTTTATAGTGCTGTAGTTGGTGGTTTACTTCTATAATTCTGTTCCCTCTTGCCTTAAAACATGAGCCTCTCAAGGGACAACCATCACAGCGTTCTGCCTGATAACGTACGCTGTAAGTAACGAATCCATTAGAGGTTAGGGAACGCTTCATACCTATACGCTTCATATGCTGTCCCATAGGGCAGACGTAGAAATCCTGTTCCTTATTATAATAAAGGCTTGCGGGACTGAATGGGTTAGGTGTGTAGCGTGGACGCTGCTCTTTATGGAAGTAGTTATACTTCACATAGGCTTCCATATTATGTACGTCCATGAACAGATAGTTCTCCTCGGAGCCATACCCCGAATCGGCTACGACTGTCTTGGTATAACGATGATAGCGTGATTTGAAAGACTCCAAGAAAGAAGGTAGTGTGAGTGTATCGGTACGATTGGCATAGAGTGCAAAGTCGGTGATGAACTGGTTCTCCGTTGCTATCTGCAGATTATATCCAGGCTTAGTCTGTCCGTTCCGCATAGCGTCCTCCTTCATGTGCATAAACGTGGCATCAGGGTCGGTCTTGCTGTAGGAGTTTCTCTCTCCCATAATCTCAAGGTGTTGGTCATACTCCTGGAGTTTATTACGTTTCTTCTCAAGTTCTTTAAGCTGTTTTTTCTTGGTTCTAACAGCCTGCTTATCTTCTTTAGTCTTAGGCTCAGGGGCTGATTCCAAAGACTTGTTCAATTCCTCGGATATCTCATCGAGCAGAGCTGCAGTAAACTCGACACCTTCTGTTTTAGCGGCATTGTCCTGCGCTATGACATCGTCAACCTGAAGCAAAAGTGTGCGTATTTGTTCCTGCAACTTGGCGCGGTTCTTTTCCACGGTTCTCTTCCAAACGAAGGTATACTTGTTGGCTTTCGATTCTATTTTTGTGCCGTCAATATATTCAACGTCAAGACTTATCAAACCTTTGGCTGCAAGTACTAATACGACTTGTGTGAATATATTGTTGATTTCCTTTTTCACACGATTACGAAAACGATTGATGGTAATAAAATCAGGCTGCTCATATCCTGCAAGATAGATGAAATGAATGTCACGCTTGAGAAGCGACTCTATACGACGGCAGGAATAGATATTATTCATATAGGCGTAAAGAATCACCTTGAGCATCATTTGTGGATGATAAGGCTTGCGACCACTGGGCTTATAAAGTTTGTAGACATTATCCAACATAAGATTATCCACCAAGGCGTCTAAAAGACGAACAGGGTCATCTTCTGCGATATCCTTATCGATTCTTTGAGGAAAAAGAATCATTTTCTTGTGTATGTAAGAACGAAAGTGTACCTTTGTCATAATGAGATTTTTTGTATGCCTAAAGGTACAAAAACTTTAGGAAATAGCAAAGCCCTGGCTTAAGAAAGTCGGGGCTTTGTGCAGAAAAAAGAGGATGTGTACATTTTGACACACCCTCTTACGTTTTGTTAGGATTTCTCTGTTGGTCTGTTCAGAGTACCTAAAGCGGAGAGAGGGGCTCTTTCTCTTGTTATGTCATAAAACATCACGAGATATCAACCTGCTGTTTTTTAGTGTATTGAGTTCATTTCAAGTAAAATGAAAAATCATAGAATTTTCTTGGGTATATCAGAATTTGGGTGTAATTTTGGGTGCATAATATCAATACAAAAAATTCAATATGGCTATTACCAACGCATCTAAGGAGGGTCTGATTCCATTCATTATAGGAGGAGCAGAAAGTATATGGAAAAATAGGACCGGAAAAGATCTTGTGTCTCTCTTTCAAGCATATGGTTTTAGAGATGATGTTTATGATAATGGGTTGCCAAAACTTAATGGATCTAATCTAAACACCTCTAAAACACAATACTCAAGAGCTAGGCTACTTCAACTTGATGAAGAAAGTTTAAAGAAGTTGATAGAACAACTTTTAATAGAGTCAGCAAATATCAATGAAGCAATAGAAGAGATAAATAACATTTTACTTCCGGATAGAGTAAAGATAACTAATAAAGGGGATCAGGGCTTCATGTGGGAGGGGGTAATCGTTAATGAGGATGTTCAAAACCTAGCTTTATTTCGGCAAAACGAAAAGCAGGTAATCAATGCTATTAAAGGAGCAAGAGTATCTATTTTGGTAGCAATGGCTTGGTTTACCAATGAAAAAATTAAAGAAGCTCTAGAGGAAAAACGTCTTGAGGGATTAAGAATTGAGATTGTGACTTTTAAGGATGGGGTAAATGCTCACCATGGAGTGGATTTGTCAAACTTTGATCATAAAGAGATTCGAGGAACACGTGGAGGAATAATGCACAATAAATTTTGTGTTATAGATAACTTAATTGTAATAACAGGAAGCTATAACTGGTCTACAAATGCAGAGTGTAGAAATGATGAGAATATTCTAATTACATGTGACCATAAAACAGCCACGAAGTATTCAGTGGAGTTTAGAAGTCTAAAATCTCTATTATAACATATGAATATCAAACGCAATATCATCTTTGCTCTTGAGAGTCGTATGAAAGCAGGCATTCCCATCGTGGAGAATGTCCCTATTCGCATGCGTGTGAACTTCTCCTCCCAGCGCATCGAGTTTACTACGGGTTATCGCATTGATGCTGCCAAGTGGGATGCCGACAAACAGCGGGTCAAAAATAGCTGCACCAACAAGTTCAAACAGTCGGCAGCCGAAATCAATGCTTCGCTCTTGGAGTATTACACGGAAATACAGTCAATCTTTAAGAGGTTTGAGGTAGAAGACGTAATACCAACGCCCGAACAGATAAAGGAGGCTTTCAATACTTTGCACAAACCTGCGAGCGAAGAGCCTAATCCCAAAAAGGAAGCACTGTCTTGCGATTTTTTCAGATGTTTGATGATTTCGTAGAGGACTGTGGACGTCAGAACGATTGGACAGATTCCACGTATGAGAAGTTTGCAGCCGTGAAAAATCATTTGATCAACTTTCGTGAAAGACTTACTTTTGAGTTCTTTGATGAGCGAGGCTTGAATGACTATGTTATTTATCTGCGCGATATAAAGGACCTGTACGCCAAACTTATTATAGAGGTAATGAACGCATTGACGAAGTTACACCTAAATATGCCTTGCTTGGAACACACGCTGGTCGTAGAACGTTTATCTGTAATGCGCTTGCATTGGGCATTCCACCGCAAGTAGTTATGAAATGGACTGGGCATAGCGATTACAAGGCTATGAAACCTTACATAGATATTGCGGACGACATCAAGGCGAATGCCATGAGTAAATTCAATCAATTATAACACCGAAACAATATGAGTCAAGAAATAAATAAAGCAGAGAAACAATATTTATCACTCATTGTTCGAGCCATCGGTTCTGACCTTGAGCATACGCAAGTACGCATGATAGCCTCTGCAAATGCAGATATGCTTTTCCACTATTGGAAAGTAGGGCACTTTATTCTCTACCTCCAAAAGAAAGAAGGTTGGGGCAGCAAAGTCATAGATAATCTTTTATTGCTGTCCGGTAACCCTTTTTCACATATAAAAGTTAAGGGCTAAAATCCGTATTTGGATTTCAGCCCTTTTTGTTACTTTTGTTTCTGCGATAAAACTTCAATAACATGGGCAAAAGTACACATTTTATCGGACAGCCGGTCTATAATCAGTTAATAAAATTACTCGATAAGCAACAAATCAAGCAAATCAGCCTTGAAACACCCCGAAGTGAAGCTTATGTGAAGCGTCTTGATGGGTGGACTCACCTTGTCATAATGCTTTTCGGTGTTCTCAAACACTTTGATTCTCTTCGGGAAGTGGAGATAGGCATGAAGGCTGAAGTAAACAAACTGCATCATCTTGGCATCGACTATGTCGTCCGTCGTAGTACGCTTGCTGATGCCAACAAGCGTCGCCCACAAGAGTTCTTTGCAAGCGTTTATGCGTACCTCTTAGAGCGTTATGGTTCTTTTTTATCGGACAGCCGTCCTAAAGGTGAACAGAAGACATGGGAAAAGCTTCTGTATATGATGGATTCAACTACGATTACCCTTTTTGACAACATACTCAAGGGTGTAGGCAGACACCCCAAGAGTGGTAAGAAGAAAGGCGGTATGAAGGTTCATACGGTGATGAAGTATCATGTTGGCGTTCCCATGGTCGTACAGCTTACCTCTGCCGCCACACATGATCATTATCTACTTAAAGAAGTGCATCTTCCTAAGGATGCTACCCTTACCATGGACAGAGCATACGTTGATTATGCACAGTTCCAGCGACTTACAGAGGAAGGGGTATGCTATGTGACCAAGATGAAGAAGAATCTCACCTATACGGAGTTGTCCTCAGTAACCTATGTAAGCCCTGATGGATTGGTTACACATACAGACAAGAAGATTGTCTTTGAGAAGGGGGAGATAAGACACCAGGCAAGACGAGTGGAACTGTGGAGTGACAACTCACATAAGTCAGTTGTCCTGTTGACCAATAACTTTGAGCTTGATGTAAAGGACCTTGAGGAGATTTACAAGCGAAGATGGGCTATAGAGTCCCTTTACAAGCAGCTCAAACAGAACTTCCCACTGCATTTCTTCTATGGTGACAGTGTAAATGCCATACAGATACAGACATGGGTGGTACTCATTGCCAATCTGCTTTGTACCGTTATCTCCAGAATGATAAAAAGACACGTATCCTTCTCGCAGCTGGTAACCATGCTGAGGCTCACACTGATGTATTACACTGATTTCATCTCATTTATGGAAAATCCACAAAATGATGAACTCATCATAATAGCTAAAAAGGCAAATTCACCACCAAAAGAACTTGACTTATTTGATTAGGGGGCTTGGATTTCAAAAAAGAATGCGGAATTACCTATATAAAGGCTATTCCGCAAGGATTTATATGTTATTTAAGTTTTACCGGACAGCAATATTATAGAAGTAAACCACCAACTACAGCACTATAAACAAAAGGCACGGGAACTACTGACCTCGGAAGAAGGCATCAAGCATCGAGGACGAAGGTGCATTGAACCTGAAGCTGTTTTTGGACAAACAAAATATAATAAAGCCTACAAGAGGTTTAGGCATTTTGGGAAAGACAAGGTCAATATGGACTTTGCCTTCTTCGCTATTGCCTTTAACATAGGGAAAATGTGTAGAAAAACCAATCTCAAGGAAATAAAAGCCGTTATGGAGCTACTTTTAGTCACCTTCAGATGCTGTATACAAGTTTATATAGGTTATTTAAAGCCCAATAAATCATTTTATATGAAATTAGCAGCATAGCTGCAGTAAATAACGAATTATGTGGTACACAAAGTAAAGGAAGAATAAAAAAGAGGATGTATCAATTTTGACACACCCTCACCCTTTACCGCTGGCGCAAGAAGCAGCTAGTGCGTTACCGCTACACGGAGGGTGGCGATGTGCGCTACTTCTTCAAGTCTATCGTGATAGCCACGAAATGTAACCGACTCCGCGTATCAGGTATGAGAAACGATGAGGTTCTTGGGCGGCTCAACCGTTTCAAGGACAATCTCATCATGAGTTCATGTCTTAATCCTAAAAACCGACAATTATGATAGAAAAGGAACAGATTCTTTTACTTACACAAGGAGGTTTGAATGTGTTTTCCCATTTCCTTGGCTTTGAGGTGAACCTTCATCGCAACTTCCGCAGTCCATTCTATGACGACAGGCGGGCTTCCTGCCATATCTACTACGACAGGAAAACTTTCTCTTACAAATTCTATGATCATGGAGATACCACCTATTCTGAGGATTGCTTCTGGTTTGTGGCAACCCTCCGTAATTTGAACCTGAAAACAAGTTTTCCCGAAGTATTGGAAACGATTGTACAAGAACTTGGATTGTATTCTTTATGTAATGGTGGAAAGCATAGCAGCCATATCACGTCAACATATAAAAAAACTATTGTTCCCACTCCTAAGGCTGATATAACCAAGTGTACGGAAGAACATCCATATAGTTTTGAGATACAGCCATTTGACGATGGTCTGCTGAACTATTGGGCACATTATGGCATCCATGAGGATACACTCCGTCGCTTTCGTGTACGGAGTCTTAAACGCTATGAAAGTGTATCTGCTGAAGGCAGGAAGTTTGAACTTTATAGCTCACCTACGGAACCTATGTTTGCCTATATCGGAAACGGCTATGTAAAGATATACCGACCTCACAGTCCAAAAATCCGCTTTCTTTATGGTGGACGGATGCCTGCCACGTATTGCTTCGGAATGGAGCAGATTCCTGCCAAAGGAGATATGCTTTTCATTACAGGTGGAGAAAAGGATGTACTCTCATTGTATGCACACGGCTTCAATGCGATTTGCTTCAACAGTGAAACGGCACAGATACCGACAAGTATCATTGAGAGCCTTCAGCTTCGTTTTAGGCATATAATACTCTTATATGATGCGGATGAAACAGGTGTACGGGAGGCACATAAACAGTCTGAACATCTGGTGGAATACAAGGTCTTGAACCTTTCACTTCCGCTAAGTGGTACGAAGTCTGAAAAAGACATTTCTGATTTCTTTGCCTTAGGCAACGGGGCAAAGGAACTGAAAGAGCTGCTTGCCAAGATGTTCTCAGATCTATATAGCCAAACCATGATGATGTTACGTTCCTGTGAGATTGATTATGAGAATCCACCGGACATTTCCAAATCAGTAGTAGCAGTAAACGGTGTGCCACTCGGCACACAGGATAACCTGTTCTGCATTACTGGAGGTGAGGGGACAGGCAAGAGCAACTATGTGGGTGCCATCCTTGCCGGAGCGTTGGGAGAAAAACGATTGCCGATAGAGAAGACCCTGGGATTAGAGATTACCCCCAATCCCAAAGGCTTGGCGGTCCTACACTATGACACGGAACAGTCCGAGGCACAGTTGCACAAGAACTTGGGTAAGACACTGCGTAGGGCTTCTTTGACGGCAGTACCGGAGTTTTGCCATTCTCTGTACCTTGCCTCTCTGTCTCGTAAGGACAGACTGAACCTTATCCGTGAGAGTATGGACTTGTTCCATCACAGGCATGGAGGCATCCACCTTGTGGTGATTGACGGAATAGCCGACTTAATACGTTCTGCCAACGATGAAACGGAAAGTATTGCCATTGTGGACGAGCTTTATCGCTTGGCGGGGATTTATAATACCTGTATCATATGCGTGCTACACTTCGTACCGAATGGTATTAAACTCCGTGGGCATATCGGCTCAGAATTGCAGCGCAAAGCAGCTGGAATTCTTTCCATAGAGAAAGATGATAATCCCGAATACTCGGTCGTAAAAGCATTGAAAGTCCGTGACGGAAGTCCGTTGGACGTACCGATGATGCTTTTCGGCTGGGATAAGGCAGAGGACATGCACGTCTATCGTGGCGAGAAGTCTAAAGAGGACAAGGAAAAGCGCAAGACTGAAGAACTCATTGCCGTTGTCAAAGAAGCCTTCCGAAATTCTTTCAAGCTCACTTACCAAGAACTTTGTGAGGTTCTGATGCGCGAAATGGAAATCAAGGACAGAACTGCAAAGAAATACATCGCCTATATGAAAGAACAACGTATCTTGGCACAAGATACCAATGGTAACTATCAAAAAGGAGAACTATGCCGTACATAGATTATAAAACCGAAGACACTTGGCAAAAACGCCTGTTCGACAAGCTGATAAGCGTCGAGGATAAACTCGACCGCCTGCTTGTCCTGCAGGATCAATCTGTTGACACGACCGTCCATCCTCCCTTGAAACCCGAATACTTGGATATCATTGATGTATCCAAGATACTCAAAGTGGAGCAAAAGACCATCTACAACTGGGTTTGGGCAGGAAAAATTCCCTATCTTAAAGCCAATGGCAGGTTGCTTTTCCTTCGGGAAGAGATAGATGAAATGGTACGGAAGCGAGATGGTTGGTAATTGATTTTCTGATTAGATTATTTTTGTTGTGTAAATGCAAGTGTTTACACAACAAAATAATTACCTTCGCAAGTAAAAAGTTGGTTGCGGATTTACCGCACACAACGATAACAGTACTCGCTTATTTCTTTGATAAGGAATTTACCATATATTGTTTGAAACTATTGAACCGATAAAGATAGCGTTGCGGACAAAAAATATTTGTAATTTCTACATTTGATGCTACTTTTAATGGAAAATTCATCGCTTGCAATGATTTTTTTCGGCATTTTCCTTGCGCATTCAAAAAAAAGCAGTAATTTTGCAGTCAATATGACCTCCCACGCTTCTCATCAGAACAGCGCACCCGGGGAGGTCTTCGAGTTTATATACGGTTATGAGGTACGAAAAGAAGCCCATAGACACATCTGAGCAGGTTAAAAAGCTATGCGATCGAGGACTTAATATTGGAGACGAAAAACTTGCGTCCCAATATCTTTATAACATAAGTTATTATAGATTACGAGCATACACATACCCTTTTCAAAATAATGGGAAAGGTGCTAATCACGAATTTCTGAGAAAGGACATTTCTTTTCAAGATGTGATAGACCTTTATTGTTTTGATAGGCGTTTACGCTCTTTAATCTTCAATGCCATTGAAAAAATCGAGGTGGCATTAAGAACAAGAATCGCCTTAACTTATTCCGTTGATGAAAATGACGCCTTTTGGTTTCTCAATCATAAGTTATACTTTCACCACGATAAGTTTATCGCATTGACACACCCTGTTGTAGGGGATTTAATGAAAGAGGTCAAGCGAAGTAATGAGGATTTTATAGCTCATTATTATCAAAAATATAGCGAACCTGCTTTTCCGCCAGCGTGGATGACCTTAGAGGTTGTTTCTATGGGAACATTGAGTAAGTTGTTTTTTGCTTTGGATAAGAATAATCCTTCTAGTAAAACAATTTGCAGGGATTTGGGACTATACAATGTCGATATTCTGAAGAATTGGATGCATGGTTTATCGTCTTTACGCAATACTTGTGCCCATCATAGTCGTGTATGGAATCGCCGCTTTACAATAGGCTTGAAGTTTCCTTATAGAACGAATTATCCTTTCTTGTCAAAGCAAGAAGCTGCAACGATAAGGGACAATAAGTTGTTTGCCTACTTATCAGTAATTTTGTATTTGCAGCAAATAATCAGTCCTGATAGCTCATTTAGAAAGAGTTTGCTCACCCTATTGGACAAATCTCCCAAATTGGTAGTTTTGAAAGACATGGGCTTTCCTGAAAAATGGAGAGAATACTCTTTGTGGAAATAATATAATACGATGGTGTATCAATTATGACACACCATCGCTATTTATCTCAGTCTGGTTTTTACAATATATCCCTTACTTTCTTCTTGTTTGTTTCTATTATTCATAGAACTTGAATAAATTACCCCCTCCTCTTCCTTTTTAGTATTTGGACTATTACTACTATTTTGTTTTAAATACTCGGATTGGTCATTTTCGTTTGATTTTTCATTTTCTTCATTTGGTTCGTTCAATGTAAGTGCAATTTTTCTGTCAAGTTCTGCTGCCTCGCCTTTGAGTGAGCGAAGCTCGTCCTCTTTTTTCCAAGAACTGTTGGCAATGTTGGTGTAAACGTCTTTATTTGCCACAACTTTTGCCATTTCCTTCTCATGCGACTCTATTACCTTTGGAATACGCTCCAAGGCATTAACGAAGTTCTGACACGCAAGTTTCGGGTCTGTTGCCAACTTACCGTTATTATAGGTATAGTAGATACTCTCCTGCCCTTTCACAAAGAAGCGGTTCACCGAACAGTCAAACAAGTCTTTTGAAGTGCTCTCCGTCTTGACCATTATGGAAAAACCGTATATCTCACCGATTTTGTTGTACTCGCCCTTGGTTCGTGCCTTCTCGTCTATTTCTTGTAAACGTGCAGCAATAGCCTTGATATCGGTGCTGTCTTCCACACCTTTGATTGTCAGTTTATTTATAGGTGTACCTTCATCATCACGCTCCACACGCTTCTCAAAGAGAGCTAAGTCAGACTGTGCCTCCTTGATTTTATCCGTATGGAAGGATACAGAACTTTCAATCTCTGCCAACTTGCCCGTTGCGGCATCACGCTCACGGAGAAAGTTCTTGCGTTCTGATTCCAAGGTGGTAATCTTCTTATCCAATCTTGCTTTCTCTAAAAGCTCGGTATTACCTGAAAGCACTGCTACGTATTCTGAGAAGTTCATGCCGCTGTCCTCATCCATCGAACCCTCATCGATGGTACGACTGCCAAGCGTGTTTGTCTTCAGCTGATTGATGAAAAGCTGCTTATTATGCAGCAGGTTAAACTTGTAGCTATCCAAGGAACGTTCCACGGCATAGATAATCACATCAACCTTGTTGTCCGCAAATTCCTTGGCGATAAGATTTCCCTTGCGCACAGCTCGTCCGTTGCGCTGCTCCAAGTCCGAAGGTCGCCAAGGCGTGTCCAAATGATGGACCGCAACGGCACGCTGCTGTGCGTTTACGCCTGTTCCCAACATAGAGGTAGAACCGAAGATAATGCGAATGTCACCACGATTCATCGCATCTACCATCGCTTTCTTTGCCTTCTCGTTTTTACATTCCTGAATAAAGCGTATCTCGTAGGAAGGGATATGATAGTCCTCTACCAACTTACGCTTTATCTCAGAATAGACGTTCCATTCGCCAGGCTTGTAAGTCCCCAAATCAGAGAAAACAAACTGCGTTCCTTTTTGTGTATCGTACTTTTGATAATAGTCATTGAGCATCTTGGCACAGTGACTTGCCTTGTTGTCGATATGATCTGAGTACCCTTTTTCATCAATCATGCGTAAATCTAAGCTCATCTTGCGGGCATAATCAGTAGTTAAGAATCAAGGGAAACAGAGGGAAATACAGAGAATGTAACTATTTGAAATAGTACCATTTAGCATTTTCTTGCTGTTTTAAGGGTAAGCAAGTACGAGCATCAAACGGCAGGAGTTCCGTTACCAAATCGTAACCCATCAGGGAAAAAGCAAAAAGGGGTTACGAATTGAATGTAAACAACTGTGTCATAGGTTTTTATTCTTCATCTTTCATTTTTCTGCATCGCTCAGGAATACTTGTTCATCTGTACCTTTGCAAGCAAAGGAAATTTAGAAAAAACGACAGAAAAATGAAAGAAAACAAACTTAAAGTATCGTTCTTCGTTCAGGCGAAACGAACCGACAAGAAAGGACTTGTGCCTGTCATTGGGCGAATCTCCGTTGGCAGAACCCATTCGGGCTTCTCCACCAAGTGTAAGACTCCGCTCGCTCTTTGGGACAGCCGTAAGCAACGGCTCATCGGTAAGAGCAGCATGGCTGTGTCCGTCAATCAGAAACTCGGCGAATGCACCGCACTCATCCACGCACGCTTTCATGAACTCTGTGAAAGAGAAGAATCTTTTACCGCCACAGACGTGAGGGATGCCTATCAGGGGCAAATCCACTGTCAAGCCTTGCTCTTGGAGAGTTTCGGGGAGTATCTCACACAGACAAAGGAGCGCATAGGCATTGATAGAGCTTTAAAGACATTCAAACTCCGTACCTACCAGCTATCCCTGCTTCGTGAGTATGTGCAGAAGAAGCACAAGGTAAGCGACATTCCTCTTTCACAGCTGGACAAGTCCTTTATCGAGGGCTTCGAGTATTATCTCACCATCGACCGCAGACTGAAACGCAGCAGCATATCCAGTACCTTATCCACCTTGCAGACCATCGTCCGCATAGCGGTAAAGAAAGGTGCGCTGGACTTCTATCCGTTCTTGGGCTACAGTTACGAGCGACCAAAAGGCGAACCGAGAAGCATTACGCAGGAAGAACTTGAGCGCATCATCGAGTTGAAGATTGAATGGAAGAACTATCGTATTGTTCGTGATTTGTTCGTCTTCTCCTGCTTTTCAGGGCTTGCCATCTCCGATGTCCGCAATCTCAGAGAGGAAAACATCGTCCTTGAAGAGGGTGAACTCTGCATCAAGGGCAGGCGAATGAAAACCAAAACTCCGTATCGTGTACAGGTGCTTCCCCCTGCGCAGACTATCATGAATCGTTATAGAGGGATAAGGGCAGGCTTTGTCTTTGACGTTCCAACCACCGACGTTATCCTCAATGGCATGCACTATATACAGCGAAATATCGGTATGAAAACTCCGCTGACCTTTCACATGGCAAGACACACCTTTGCATCGCTTATCACGCTTTCGGCAGGTGTACCTATTGAAACGGTGAGCCGTATGCTCGGACACACCAACCTGAGAACAACACAGGTATATGCAGCGGTTTCCTCCGAAAGAATACATAGGGATATGCAGATAGTGCAGCAGCGAATACAAGATACATTCACCCTAAAACTTTGA

Protein sequences of DBSCAN-SWA_3

>CP022041|1279773:1354453|1289813_1290629_+|ASE18830.1|DBSCAN-SWA
MKKMFFPLFGFALLFLTACYNQVSTGDHSAIDVEVQMKGDSTRYGLACDGCSDSIIVLLPNEGGDPVKFDIVTAKRNGMVYGTPEIGDELAIVPNPIDPYEAEMVINLEQMKGTWTFQVLPKLKPNPTKTEEEILAGMSDSMKAALFTPREYGFTLKSYNQASPVGYVMKANSLEDESPVEYPKVTVYTSWHIFNGRLYIYKDTLDEQGHRIPQDSVGFDSGSMRYLSEDSMAALFGKKVMQYHRKKNALEANKEAQKAEEKNAIIQSFKK
>CP022041|1279773:1354453|1312540_1313494_+|ASE18844.1|DBSCAN-SWA
MNTKHIILMACAALLGATQANAQGQDLSILTANTDARTAAMGNASAAAEGMYLYNNPAAFFATDKKFTADASASLFEKAEGADGTFGIYALSAGYKLAKRHAVFVGFRYAGGLSLKGSDLLGNPTKDYKPYNWTLDLGYTYFLGKGFATYATGSLIYSHLSKNATGAVFSVGGAYQNNELTLANKPANLMLDAKVGAIGPQLDYGNKHKTTLPTYLAVGGALSVEVAEKHQVAAALSSRYFFQPSEAKLFMLGGGLEYTYNKMVSVRAGYEYGDHDLSHVTMGAGFKYHGLRLNGAYNLKTADTGSSYCTIGIGYDF
>CP022041|1279773:1354453|1293001_1293547_+|ASE18832.1|DBSCAN-SWA
MMFRKRERRKVPILNTTSTADISFMLLIFFLVASSMDLDKGLSRQLPAIDKTKTPPAAVDSRKVMRIVIDAKNQVTLDGKAVTMKELLQRATQLIQTNGKGHLIQLQSSRNASYDTYIHVQNQLVAAYNTLRNQRALNLFGKEFELCSNEQQKQIADELPMRISEVYTVSKADNTEKGGTE
>CP022041|1279773:1354453|1343804_1344602_+|ASE18862.1|DBSCAN-SWA
MAITNASKEGLIPFIIGGAESIWKNRTGKDLVSLFQAYGFRDDVYDNGLPKLNGSNLNTSKTQYSRARLLQLDEESLKKLIEQLLIESANINEAIEEINNILLPDRVKITNKGDQGFMWEGVIVNEDVQNLALFRQNEKQVINAIKGARVSILVAMAWFTNEKIKEALEEKRLEGLRIEIVTFKDGVNAHHGVDLSNFDHKEIRGTRGGIMHNKFCVIDNLIVITGSYNWSTNAECRNDENILITCDHKTATKYSVEFRSLKSLL
>CP022041|1279773:1354453|1333136_1333403_+|ASE18854.1|DBSCAN-SWA
MRQAISIIVLYALINILSLLFNIISFSTDGKIDIGFPFIFIHLTSAKYDPTFPYNKLLIEPFLWDIIFLFTIVCLYLCCLKFIKRIRD
>CP022041|1279773:1354453|1350429_1351362_+|ASE18867.1|DBSCAN-SWA
MRYEKKPIDTSEQVKKLCDRGLNIGDEKLASQYLYNISYYRLRAYTYPFQNNGKGANHEFLRKDISFQDVIDLYCFDRRLRSLIFNAIEKIEVALRTRIALTYSVDENDAFWFLNHKLYFHHDKFIALTHPVVGDLMKEVKRSNEDFIAHYYQKYSEPAFPPAWMTLEVVSMGTLSKLFFALDKNNPSSKTICRDLGLYNVDILKNWMHGLSSLRNTCAHHSRVWNRRFTIGLKFPYRTNYPFLSKQEAATIRDNKLFAYLSVILYLQQIISPDSSFRKSLLTLLDKSPKLVVLKDMGFPEKWREYSLWK
>CP022041|1279773:1354453|1325087_1326713_-|ASE18940.1|DBSCAN-SWA
MKTKAYKYIVGVLALSLFTACDFQKVNTNEFELLPEEGLMDGISIGGPITAMQKCVFPVGTQADGTSVANRYQTAYNLAADCWSGYFGQNNNWGGPNNLNYFLKDGWVASSYTESYSTVVPLWQDLKGKTETQFPEVFALAQILKISAWHKATDMFGPIPYKEAGKGLITVPYDSQEEVYKAMFKELSDAIEVLTKYADNGNSKLLPNADAVYAGDVHKWVVYANSLMLRLAMRVYYADAALSKKYALQAVNHSYGVMKTKDDEAKMERGASLEFKNNLDVLINQYNECRMGSSMLAYLGGYQDPRLPKYFNTSTVSQAVTVGTYGKYSGVPTGHDVSSNDAFRDSSRPAITSTTPTYWMRASEVYFLLAEAALHGFAVGGTAESLYEKGIEMSFEENGIASSEVADYMSSGLKPSAYSFHLTNPGVNVDVPAVTEATTAWSGTDEEKLEKIMIQKWIALYPNGQEAWTEYRRTGYPKLHSVVTNYSNGEIDSEVGIRRMRFPTNKSTSAEDIANLESARKLLRGGLDKAGTRLWWDNKNH
>CP022041|1279773:1354453|1322765_1323911_-|ASE18849.1|DBSCAN-SWA
MNKHIFKHIAVAFAACCVVSCQDSESDLLKQKVYFDSNLYKVEMPDSGSTLGVDITSRLSNKQDGAVDVSYSLADSSLVALYNSKYGTDYVALKHQNVTFSKASSTIAAGSIYADKVSLTLNNLDQLAEGKNYMLPIKLHSSSTPVIDGEDVEYIILAKPVKITKAGDFYNKYISVKFPAGTYFKSFTYEALVHSIWWGSNCTIMGSEGLMIFRVGDVGGGISSGILQAAGRQHYEAPEKLSINKWYHVALTYDQATGKTVMYLNGTKWAESAWNISGFDPNADVGFNIGKIPGFPWGERPFYGYMSEVRVWSVARSENQIKQNMLSVDPKSDGLELYFKLNGSETVNGNKIKDSAKGIECTTGGLEFTTLAQPLTMKDLQ
>CP022041|1279773:1354453|1351403_1352921_-|ASE18868.1|DBSCAN-SWA
MSLDLRMIDEKGYSDHIDNKASHCAKMLNDYYQKYDTQKGTQFVFSDLGTYKPGEWNVYSEIKRKLVEDYHIPSYEIRFIQECKNEKAKKAMVDAMNRGDIRIIFGSTSMLGTGVNAQQRAVAVHHLDTPWRPSDLEQRNGRAVRKGNLIAKEFADNKVDVIIYAVERSLDSYKFNLLHNKQLFINQLKTNTLGSRTIDEGSMDEDSGMNFSEYVAVLSGNTELLEKARLDKKITTLESERKNFLRERDAATGKLAEIESSVSFHTDKIKEAQSDLALFEKRVERDDEGTPINKLTIKGVEDSTDIKAIAARLQEIDEKARTKGEYNKIGEIYGFSIMVKTESTSKDLFDCSVNRFFVKGQESIYYTYNNGKLATDPKLACQNFVNALERIPKVIESHEKEMAKVVANKDVYTNIANSSWKKEDELRSLKGEAAELDRKIALTLNEPNEENEKSNENDQSEYLKQNSSNSPNTKKEEEGVIYSSSMNNRNKQEESKGYIVKTRLR
>CP022041|1279773:1354453|1338541_1339069_+|ASE18858.1|DBSCAN-SWA
MLEYKRYQILNLNFINELDTVILDSKLKYISDFIFRQVQGKSVFLFEMKPTKTSILYDIDPESKYHSINSRKIIYTKNLNLSKKVISMIVEDESFYLGHLLIIIGTFSKSKISNISNMWENLLETGIEYFKMGNDGESFYWCNPQINSAEEEFKLFINELNTFANGIKHINNENG
>CP022041|1279773:1354453|1335636_1335981_+|ASE18857.1|DBSCAN-SWA
MKKNLLFSFDDEITTGVYYDIDGHKIVVYFAAYYDNGRFVEKKCQLIIEKWEYAKSKLSVDNRYKDLEDHIGIISMILDMHIADKKLFLTVNTLDGQYVDLLFYNCNVKIEDIS
>CP022041|1279773:1354453|1330183_1331287_-|ASE18852.1|DBSCAN-SWA
MTLYPKLITDALEKVIYPGTKKNIIESEMLADTPSINGNKVSFTLIFPRETDPFLKSTIKAAEAQIHYSVGKEVEVTITTEFKNAPRPEVGKLLPQVKNIIAVSSGKGGVGKSTVSANLAIALARLGYKVGLLDTDIFGPSMPKMFGVEDARPYGVEKDGRQLIEPVEKYGVKLLSIGFFVNPDTATLWRGSMATSALKQLIADADWGELDYFILDTPPGTSDIHLTLMQTLAITGAVIVSTPQNVALADARKGIDMYRNDKVNIPILGLVENMAWFTPAELPENKYYIFGKDGCKNLAKELGCPLLAQIPIVQSICENGDNGTPAASQVDTITGQSFLSLAQSVVTVVNRRNKEQAPTKIVDVKNG
>CP022041|1279773:1354453|1279773_1280643_-|ASE18823.1|transposase|DBSCAN-SWA
MDHAQDWLLFEDNIGESLSIDETCLSCGEVYTFLTNKAGKGREGTLVAVVKGTKAEDVIQILKKINLSKRKTVKEITLDLSSSMMRIARAVFPKALITNDRFHVQKLYYDALDDMRIAYRWMARDKENEEIKEAKCKGKEYIPFRYSNGDTRKQLLARAKFILTKHKTKWTETQKGRAEIIFEHYPTLKKAYDLAMKLTDIYNIKSIKDAARLKLAKWFNEVEELGVDNFYTVIDTFENHYQTILNFFVNRATNANAESFNAKVKAFRAQFRGVTDIPFFLYRLMKLCA
>CP022041|1279773:1354453|1341802_1343464_-|ASE18861.1|transposase|DBSCAN-SWA
MTKVHFRSYIHKKMILFPQRIDKDIAEDDPVRLLDALVDNLMLDNVYKLYKPSGRKPYHPQMMLKVILYAYMNNIYSCRRIESLLKRDIHFIYLAGYEQPDFITINRFRNRVKKEINNIFTQVVLVLAAKGLISLDVEYIDGTKIESKANKYTFVWKRTVEKNRAKLQEQIRTLLLQVDDVIAQDNAAKTEGVEFTAALLDEISEELNKSLESAPEPKTKEDKQAVRTKKKQLKELEKKRNKLQEYDQHLEIMGERNSYSKTDPDATFMHMKEDAMRNGQTKPGYNLQIATENQFITDFALYANRTDTLTLPSFLESFKSRYHRYTKTVVADSGYGSEENYLFMDVHNMEAYVKYNYFHKEQRPRYTPNPFSPASLYYNKEQDFYVCPMGQHMKRIGMKRSLTSNGFVTYSVRYQAERCDGCPLRGSCFKARGNRIIEVNHQLQHYKQKARELLTSEEGIKHRGRRCIEPEAVFGQTKYNKAYKRFRHFGKDKVNMDFAFFAIAFNIGKMCRKTNLKELKAVMELLLVTFRYFIQVYIGYLKPNKSFYMKLAA
>CP022041|1279773:1354453|1313538_1315113_+|ASE18845.1|DBSCAN-SWA
MKRTLFSICALVLSLTASAQIIKDTPKGKLIENLYRSSKSWVKKGWTGVQPGRYEGLVSKIVIGEDGCIYIYNPLSGLDSKSWLKLERQPDGKYRAKLPQDILTDDYGGDDDEEESSERTISLTRLVSSDDGKNYEPIGANNYVDFTVEGRTLKMSGMGQKKQIWGASFNNKWERNYGGDWALTIEPLKEQLITPPATATKSQYTVTSKSDPSPRIVEVMTNNNDIYVKGLFKAEKLANVWVKLTKQGDKAVMPTNQYLGITKKTDFKKYDSDKSEYHTFAAAFESETKAAENLEFSIDATGKLTASKILRTSLGRASNDNITGEDYIESYEGLTLTPYVQKEVGAPATPEYFYLTSTPNYDNTSNEIKLAFYVKNADINGNVLDPEKMYYNVYINGSTEPFKFKKSASQYNDMHEEEMTNIPFNYKDKRNYDFKVIDNLRILHFYDSSITRLKVVMVYESDGKKYSSEPMVASLTTDGIESANFNKTTTEKYYTVDGRQIQKLQKGLNIIKSSDGTTRKVVVK
>CP022041|1279773:1354453|1331417_1331795_-|ASE18853.1|DBSCAN-SWA
MGRNKFAEDEIKEIAKLLRLKNAGNRAKQKLVRHDLRTIYEFNISDFNEPGKAFGEEELQGAIQRGAIQILDDATIADMKAKRARDKARDEATREQQAIEAGEMTDWKAVAKEWEEWENSQNNGN
>CP022041|1279773:1354453|1306499_1308119_+|ASE18841.1|DBSCAN-SWA
MELKKTLYSLMLGGILLCLFSCAKEDEFEMPTLVLSENSIAFDKGVSERNISVTTNQNSWIASSPQEGDWLSLVQDGNVLKVKVTENKIGTERTSYVLVNANGASGKIAVTQSAADVTLDVVPNAIYLPQTGGEKTIDITTNSSVYDVTTSEEVSWLKIVKSEEEIKLIAERNDTYQKREVKLYAKSGSVIREIVVSQSGIQRYLLPIHPGVPQDEHKIMDFELGRGSYLREYQAAMPAYGLEETYTFITASPIFTLIQYCSTDGINPSQIIMIGDGRKAIDAVKDKAFDKFLTDNGYVRSNSQSDREYTNDKDLLSLKVYISEKENNEGVNLTFTPIMKQNGEYKTFSKLPFYPLELLQKDNVKLAQIEQYEQKAGSTEEERSLNEHKNTEVSQIQYKLKASTDPSAAYGRIHIFYTTDKDGDAPDNLGSVQIGALLFKDTNLGVWKYGTKWVATKEIKKVLGDEGFSFLRTSGNNHFFVRESDHLVIDVTCVLDNAMPVLALLYSYDPSVSGASSKAIKTQAKMIRNFAAAKKALKF
>CP022041|1279773:1354453|1335329_1335629_+|ASE18856.1|DBSCAN-SWA
MKIKNILAVFIIVGGISYALYFSLVTDVLLKYGETIHTKAIIEERLTGKTSDPVLRYRFLYENQAYIGFVSETSRLHVSDTINIVFLKSRPSINKPLIK
>CP022041|1279773:1354453|1304752_1305565_+|ASE18840.1|DBSCAN-SWA
MRKFCLKIHRWFALPLGVIMAILCFSGLAILLIKDLAPLFDMNAKEMPIYTIVVRLHRWLFMKPENAHEGGQSLGRILTAVSAICMSIVLLSGVVIWWPKTKKALKSRLTVSTNKGFRRFVYDSHVSLGIYVFIFLFLMALTGPVFSFGWYRAGMSKLFGQPMPPKEMKMQQPKDGMKQGGTNDKAFAPTDASQMKGQPQAHKEGAKDMKGDQHGKKPKGGKLFKQLHTGTWGGWFSRVLYAIAALIGGFLPISGYYLWWKRRSAKKKKA
>CP022041|1279773:1354453|1326719_1329830_-|ASE18851.1|DBSCAN-SWA
MRMIHETKQKHLYFSVAFALSIALAPTSVYAVGNPVGSPDASMPQAVQQNGNHKVTGRVVDSAGEPLIGATIMVEGTKEGAVTDIDGNFTINTTSKAKLVISYVGYTTQTIPVGDKTTIDVTLKEVANTMNEVVVTALGIKRAEKALSYNVQSVGSNELTRNKDANFVNSLNGKVAGVSISKSASGVGGATRVIMRGAKSIEGDNNVLYVIDGIPIFNFSGGRDSGIMGEGRVSSEGIADLNPEDIESISVLAGPSAAALYGSNAANGAILITTKKGKEGRVDISFSSSADFSSPLLMPKFQNTYGNKLGSYESWGEKLATPSSYDPKKDFFRTGTNFINALTLNMGNEFNQTFASVATTNSRGIVPNNTYDRYNFTIRNTTRMFKNRVQLDLGASYIKQKDNNMVSQGEYWNPIVAAYLFPRGESFEGIKTFERYDNVRNFPTQYWPISDSRFANQNPYWTAYRNLAPDDKDRFMFNAGLTYNIFDWLSVAGRIRLDKTFITSERKIYASSFNYFAKEKGAYDYYDYKDHQTYIDAIANINKTFGKFSLAANVGYSYSDYASLTRGYGGNLVLVPNKFSLNNINPTDSKIREAGGDSKVRNVAAFASAELGWRSMVYLTLTGRNDWNSRLVNSSEESFFYPSVGLSGIISEMTKLPSFISYLKVRGSYTEVGSPVSRSGMTPGTITTPIVGGSLKSTDIYPFTDYKAERTKSYEFGLTARFWKKLSFDFTWYKSNTYNQTFIGELPESSGYKAVYLQAGNVENRGVEMALGYSDNFGGLQWNSSLVYSKNVNEIKEMVKDYHHPLSPKPINIPEVSKDNGRVLLKVGGSINDIYARKVLAKDNQGFVNVSPSGGMNLETVEPIYLGKTTPDFTMGWNNNFTYKNFGLSFLINARVGGIVTSSTQALLDRFGVSKASADARDAGGVMIPNQGLYDAKKYYTLVATGENDLAGYYTYSATNVRLQELTLSYKFNSKLFNNVIKDLTLSFVATNPWMIYCKAPFDPELTASTGTYGQGNDYFMQPSLKSYGFSVKFKF
>CP022041|1279773:1354453|1287270_1287804_-|ASE18828.1|DBSCAN-SWA
MDYQVIINKYYPEDNELRHILLVHSRAVADKALAIADRHPELSLDRQFIEEAAMLHDIGIVRCNAPGIQCFGTEPYICHGRIGAEMLRAEGFPRHARVCERHTGAGITRSQIIAQKLPLPQQDFLPETMEEKVICYADKFFSKSHLDEEKTIEQAIASLSKFGEEGVARFREWVKMF
>CP022041|1279773:1354453|1299239_1301171_-|ASE18837.1|DBSCAN-SWA
MDKRTITGFVLIALILFGFAWWQQPSAEQVAQQRAEFVKDSIASAKKAQTAKLAAEKQAQQKAAQATDTTALFYAALNGKAQDIILKNSKVELTLSTKGGVVKKAVIKNYIGHNIAVKDGSQDQKNVTLFSGDDQSLNFMLAAKNSNIETKDLIFTPSNVTDSTVTLTAVAGEGKTLTLNYTLGKDYLLNMSLQAEGMGGLFAPNYNQIDINWQERCKQQERGFTFENRYATLTYKKHDGGTDYLSETSEKEETTEDSMDWVAFKNQFFSAVMIAKDNFATGAKLKSTPLEKSSHYLKHYEANMKAGFDPTGKRPSEFEFYFGPNDFRLLQSVETESKFAKELDMERLVYLGWPLFRIINRWFTLYVFDWLSKVFPMGVVLILITLLLKLITFPMVKKSYMSSAKMRVLKPKLDEATKQFNKPEDQMQKQQAMMQKYSEYGVSPLSGCLPMLIQMPIWIAMFNFVPNAIQLRGQSFLWMHDLSTFDPIFSWSHDVWLVGDHISLTCILFCGANLLYTWFTMQQQKDQMVGQQADQMKMMQWMMFGMPLFFFFMFNDYSSGLNFYYFISLFFSAAIMWALRKTTNEEKLLAILEARREERKNNPKNNMGSGLFARMQALQELQKQQQEELRRKQDELNKKKKGL
>CP022041|1279773:1354453|1349744_1350053_+|ASE18866.1|DBSCAN-SWA
MPYIDYKTEDTWQKRLFDKLISVEDKLDRLLVLQDQSVDTTVHPPLKPEYLDIIDVSKILKVEQKTIYNWVWAGKIPYLKANGRLLFLREEIDEMVRKRDGW
>CP022041|1279773:1354453|1323951_1325070_-|ASE18850.1|DBSCAN-SWA
MKNFKYISSLVLLCAGVLFCGCSKMTEVENEPYDHIGGYNTMNNAESEKYYADLRAYKQQAVNYGRPVAFGWYSNWSPAGTYRRGYLTSMPDSMDVVSMWSGAPNRFNITPEQKKDKEFVQKVKGTKLLEVTLLSYIGKGRTPDSVYTAVEKQAEKEGWANDQARVEEAKKKARWKFWGYEGVAGSDNHKEALARFAKALCDSLVANDWDGYDIDWEIGSGVFDMDGTLSTNADLVYLVKEMNKYIGPKSDPEHKGHRLICIDGHFGGLTEDLDGYVDYWIDQAYGRTTHFDYYGVDPKTIITTDNFESSFKSGGQLLRQAKSMPSKGYKGGVGAYRFDNDYDNTPNYKWMRQAIQINQQVFKERMGQTTQP
>CP022041|1279773:1354453|1336116_1336590_+|ASE18941.1|DBSCAN-SWA
MAKDFNIYTYPTFFSLLLIMLIPFALSVDDIMNNHQSNMKIILWISVFIIIILVYGLIKTRKRKIVINELGLLITEKEGNIKIPWEDISHIFFCSTPIWGLYVKITFTNRRNPLIIDFGKSSLWSVNFYRFRIAILAFSHKKDIIVVKSNQWYLKLI
>CP022041|1279773:1354453|1341252_1341597_-|ASE18860.1|transposase|DBSCAN-SWA
MKNHQLLRCIFPDVLADYFDVVDIQESVSQIDFWLDERNFMEKSDHKLGTVSSYGFTSERVIQDFPLRGKAVYLHVRRRKWRDSSNGEIFTYSYDDLTAEGSRLSPEFVSFLKE
>CP022041|1279773:1354453|1286245_1287136_-|ASE18827.1|DBSCAN-SWA
MIRKNPYTEEKYKHYKVTAPAPLLEWLLANLNESKSKVKATLQNRGIKVNGKCVTQFDHPLKAGDKISVSKSKKNDLFRSRYVKIVYEDRFLVVIEKNIGILSMAAGHSSLNVKTVLDDYFRKTKQKCTAHVVHRLDRDTSGLMIYAKDIQTEQLLEHDWHNIVYDRRYVAVVSGEMEHDEGTIANWLKDNKSYVTYSSPVDNGGKYAVTHFHVLDRTVAHSLVEYQLETGRKNQIRVHSADMGHPVCGDIKYGNGDDPLHRLCLHAYVLCFHHPVTHQRMEFETPVPQVFRHLFK
>CP022041|1279773:1354453|1303578_1303824_+|ASE18939.1|DBSCAN-SWA
MELDTTNMCSHLQKKLFNEEGVYYPIWQAMQNDDEITAVIRSRQLHIYRNGKKVLVLPGKAAPKIIREDSLNELLPKDLLK
>CP022041|1279773:1354453|1287893_1289672_-|ASE18829.1|DBSCAN-SWA
MGKKIEFSLIYRDMWQSSGKFQPRKDELVRIAPVFVEMGCFARVETNGGAFEQVNLLAGENPNESVRAYTKILHEAGIKTHMLDRGLNALRMYPVPDDVRALMYRVKHAQGVDITRLFDGLNDIRNIAPALKWAKEAGMTPQGTLCITTSPVHTIEYYCKLADEEIAAGAEELCLKDMAGIGQPAFLGELTRRIKEKHPDIILEYHGHSGPGLSMASMLEVAKNGIDILDVAIEPLSWGKVHPDVISVQSMLKNAGFDVPEINMDAYMKARAMTQEFIDEWLGYFINPQNKIMSSLLLECGLPGGMMGSMMADLGGIRSTINNLRKKKGEPELSVDDMLVKLFDEVAYVWPRVGYPPLVTPFSQYTKNIALMNLLTLEQGKGRFVMMDDSMWGMILGKSGRVPGEICQELKDLAKQKGLEFTDADPHTLLANALDDFRKEMDENGWDYGQDDEELFELAMHPEQYRNYKSGQAKKNFLADLQAAKDAKLGAKVSPEEAAAFKHAKADAIVSPVKGQLFWEFQGDGEAAPAIEPFIGKEYKEGDVFCYVQAPWGEFVTVPAALGGKLVEINAKQGAKVDKGDVIAYIERAHEE
>CP022041|1279773:1354453|1345736_1346954_+|ASE18863.1|transposase|DBSCAN-SWA
MGKSTHFIGQPVYNQLIKLLDKQQIKQISLETPRSEAYVKRLDGWTHLVIMLFGVLKHFDSLREVEIGMKAEVNKLHHLGIDYVVRRSTLADANKRRPQEFFASVYAYLLERYGSFLSDSRPKGEQKTWEKLLYMMDSTTITLFDNILKGVGRHPKSGKKKGGMKVHTVMKYHVGVPMVVQLTSAATHDHYLLKEVHLPKDATLTMDRAYVDYAQFQRLTEEGVCYVTKMKKNLTYTELSSVTYVSPDGLVTHTDKKIVFEKGEIRHQARRVELWSDNSHKSVVLLTNNFELDVKDLEEIYKRRWAIESLYKQLKQNFPLHFFYGDSVNAIQIQTWVVLIANLLCTVISRMIKRHVSFSQLVTMLRLTLMYYTDFISFMENPQNDELIIIAKKANSPPKELDLFD
>CP022041|1279773:1354453|1294115_1294625_+|ASE18834.1|DBSCAN-SWA
MAHRSLDRLDKKILHLISEDARIPFLEVARACNVSGAAIHQRIQKLTNLGVLKGSQFIIDPERIGYETCAFIGLNLKNPEKFDDVVEALRQIPEIVECHYTTGEYDLFLKIYAYNNHHLMSVIHDKLMPLGLSRSESSISYNAVIDRTLPIEGMKVADVVLDDDEEDEE
>CP022041|1279773:1354453|1281625_1282603_+|ASE18825.1|DBSCAN-SWA
MSEINNKTIKDYLIGKATAKEMEQLAEWLAVSEENQKEFFEMELAFHLGKNNSLVTSKKIEEAETKLFDQITEYEEQNRNKNKLYFLRYAAAIIVAVLLIGGGLFAYLHQSAETITVAAMNEVKKVVLPDNSTVWLNKGATISYAGNFEGDERKVNLKGEALFHVTKNAEKPFIVNSDGASAKVLGTTFNFKDQAADGKEVISLIEGRLEVTGLNGEGKVVLHPNQKATVSKDSKTIKTENSYALADAVWRDDIIPFNNMRINEIAKILEQLYDYKIIVDAKLDHTKTYTGVIKRNKDIRNVLDGLSYTISFHYNIHDKEITLSE
>CP022041|1279773:1354453|1317940_1319164_+|ASE18847.1|DBSCAN-SWA
MEYVKFKDVIINSQYGYTATETSQTEGTYKYLRITDIVPYYVNFDTVPFCKITEKDVSKYIVKEGDILIARTGATTGYNYVVPSGISNTVYASYLIRFIVDKKLVLPLFMKYVLKTQSYYGFINNYIGGSAQPGMNAKVFTKFNIPKLSLVTQQKIASILSSYDRLIENNTRRIRLLEQMAENLYKEWFVRFRFPEHENVEIVNGLPKGWKTIHIKELAQLKSGYAFKSEWFVEEGEAVAKIKDIGNILMDTSNFSYVDKENCIKAKKFLLTTGDLTIALTGATIGKISIVPKHKGNIYTNQRLGKFFLGDNPMEKLPFLYCLFKQESMVSNIVNLSNSSSAQPNISPEQIEKIKILGNHDIISMYNKTCNPLFSNILALYSQNQLLTRQRDLLLPRLMSGKLEVKS
>CP022041|1279773:1354453|1295266_1296889_-|ASE18835.1|DBSCAN-SWA
MTDKIQTSLRDSAAMRWTALLLLSLAMFCAYIFVDILSPIKELMQEQRGWDSTAFGTMQGSETFLNVFVFFLIFAGIILDKMGVRFTAILSGAVMLAGALIKYYAISDSFAGSALDVWFTNNLNHIPVFEQLGVSPFYQGMPASAKVAACGFMIFGCGVEMAGITVSRGIVKWFKGREMALAMGSEMALARLGVATCMIFSPFFAKLGGDINVSRSVAFGVVLICIALMMFIVYFFMDKKLDSQTGEAEEKEDPFKISDLGKILSSMGFWLVALLCVLYYSAIFPFQKYAVNMLQCNLTFHELPSGSYWASSSVTIIQYVIMLVVAATAFMFNFMKNKALKNLMLFFSIFFLVAYCYMGYMRQSAESIFAVFPLLAVGITPILGSYVDHKGKAASMLVLGSLLLIVCHLTFAFVLPQFKSSQVGGVIVAYVTILVLGASFSLVPASLWPSVPKLVDAKIIGSAYALIFWIQNIGLWLFPLLIGKVLDKTNVGVTDPTQLNYTAPLVMLAGLGVIALIIGLTLKVVDKKRNLGLEEPNIKE
>CP022041|1279773:1354453|1297077_1299237_-|ASE18836.1|DBSCAN-SWA
MNKNLTMAMTAALMMSGSVAQAQDVNIGRSNITLTSDLMTPETLWAMGRIGAAQASPDGKKIVYQVGYYSVKENKGHQVLRVMDADGKNDRLLTTSAKSEGDAAWVDNNTLAFLTGGQLWTMNADGTNRKQLTHSDIDIEGFRFSPDRKRVVLIKSIPYYGTIKQNPSDLPKATGMVITDMNYRHWDHYVTTNAHPFVADVTPEGIGAGIDVLEGEPYESPLAPFGGIEQIDWSKDSKFIAYTCRKKEGTQYAISTDADIYIYNVETRQTKNLCKPADYVEPKIDATKSMRNQAVNHQAGDMNVGYDVNPKFSPDGKYIAWQSMKNDGYESDRNRLCVYELATGKKTYVAESFDSNVDDYTWSLNSKDLYFIGVWHATVNVYQTNLKGEVKQLTEGDHNYVSISLLGDKKLLAIRQSISQANEIFAITPAKKEKASVQTQLSFENKHIYDQLALGDVKSRWVKTTDGKEMMEWVITPPHFDPNKKYPTLLFCEGGPQSPVSQFWSYRWNFQIMAANGYVIIAPNRRGLPGFGSAWNEEVSTDWTGQCMNDYLSAIDDAANNLSFVDKDRLGAVGASFGGFSVYYLAGIHNKRFKCFISHDGAFNLESMYTDTEEAWFSNWEYDDAYWNKDKSEAAKRTYANSPHLNVDKWDTPILCIHGEKDYRINANQGMGAFNAARLRGIPAELLLYPDENHWVLKPQNSVLWQRTFFNWLDRWLKK
>CP022041|1279773:1354453|1292489_1293005_+|ASE18938.1|DBSCAN-SWA
MMKIKGIAKMDEERISQRVLYVIVALSAIVFLAFYLIGYDTPFTGNTAFNAPMLTDVLLGFMWGLLAITTTASIVAVVRGIRRANRSEGMTNGIPARRITYTTYGITALILLLTFVFGSTQTMMVNGENFTDSFWLRITDMFVNSSLLLLVLAAGVVAFGATRYYRKGRGK
>CP022041|1279773:1354453|1282677_1285737_+|ASE18826.1|DBSCAN-SWA
MRKLYALLIGALAPLCSYAQTTFPEWQSQYTTGLNKIEPHAYVLPYSSVDKLQQPGGYEQSDYYMSLNGKWKFHWTKNPDNRPKDFFQNDFAVQGWNDINVPGNWERQGYGLPIYVNETYEFDDKLFQFKKNPPLVPYAQNEVGSYRRTFKIPSTWKGRRVVLCCEGVKSFFYLWINGTYVGYNMGAKMPSEWDITKYLNDGENTIAMEVYRWASGSYLECQDYWRISGIEQDVYLYSTPTQYIADYNVAAGVDKQDNGSFNGNFSLTTNIKGAGSGSVSYVLTDEKGNTILSEDKAVSAKNNDEMVNFTTKTIQNVAAWSAEHPNLYTLLITLKDKNGNVTEQTGSKVGFRTIEIKNKQLCVNGTPILVKGANRHEHSELGRTVSKELMEQDIRLMKQNNINLVRCSHYPNDSYWYQLCDKYGLYVIDEANIESHGMGYGKESLAKDSTWLTAHMDRTRRMYERSKNHPSIIIWSLGNEAGNGVNFEHTYRWLKNADKTRLIQYERAEENFNTDIYCPMYQSLDHMKAYAKRTDITRPYIMCEYLHAMGNSCGGMKDYWDLIESEPILQGGSIWDWVDQSFRELDKNGNWYWSYGGDYGPKDVPSFDNFCTNGLIAADRTPHPHLSEVKKIYQNIKSELVSNEKGITIKVKNWFDFTDLNAYQLNWQIVNENGKVIAKGTQHVDCAPHETTTITLPAVSATTDKEQYLNLEWYPANDALILTKNDVVAYDQFVLKKASDCTTFLPREKQRMTYKVNENTGELTSLKSGNQEFLEAPLSLSFYRPATDNDGRDQFGVRVWRKDGIDSISQKVTKITRTKDVTRAEADIIGKKGNVIGKAVFTYQPQKNGALAVKVDFTPDTAAVKALARLGLTFCVKDTFGKVEYNGRGDIETYNDRKAAGFIGHYKTTAEAMFHYYVKPQATGNRTDVRWVSISDTRNRLMVAAKSPFQFSVTPFSDSVIDRATHINQLSRDGLLTVHLDTNQSGVGTATCGPGVAEKYRVSVKPTSFEFVLYPAMAK
>CP022041|1279773:1354453|1280758_1281103_-|ASE18824.1|transposase|DBSCAN-SWA
MKNHQLLRCIFPDVLADYFDVVDIQESVSQIDFWLDERNFMEKSDHKLGTVSSYGFTSERVIQDFPLRGKAVYRHVRRRKWRDSSNGEIFTYSYDDLTAEGSRLSPEFVSFLKE
>CP022041|1279773:1354453|1291368_1292202_+|ASE18831.1|DBSCAN-SWA
MKKLIALFSIITILSFSCSTIVSAQAPAKAATTATADTLSDDALNETGVADTATVKTPTAQDTGIHQSLKRKFIEGNAGFMSLVALALVLGLAFCIERIIYLSLSEIDAKRFVGKLEDMIVAGEIEQAKALSRDTRGPVASICYQGLLRIDDSIENIERSVTSYGSVQSANLEKGCSWITLFIAMAPSLGFLGTVIGMVMAFDQIQEAGDISPTIVASGMKVALITTIFGIIVALVLQIFYNYILSKIDHITAQMEESAITLLDAIMKYKLKSIHNS
>CP022041|1279773:1354453|1319179_1322380_+|ASE18848.1|DBSCAN-SWA
MKSFISEDDIEQTLCTRLSQPEFGWKRIECDPSVEAQDDVSKTGRRNSSECILPAVFLTALERLNPQIDKSILAQVVADFRKDYTGKDMMDTNYKFYNYLRNGINVKVKKNGKDDFDIVRLIDFDNVENNDFHCVNQMWIKGRIRYRRPDVLLFVNGLPMVFIELKNSTVKIKEAYEKNLVSYREDIPNIFALNQICVLSNGMQTKLGAWNSKYEFFFDWLKVNDEHEKLDREHIAEYGLSIINLIDSLFRKERLLDYIENFIFFDNKRKKIIAKNHQYLGVNNLMKSVECREELKGKLGVFWHTQGSGKSYSMVMFVRKVRRKLKGNFTFLVITDRDDLDTQIHKTFVRSEVIGEKEECQPKNAAQLREFLSGNKPMVFTLIHKFQYDKTKKYPLLSERNDIFVLVDEAHRTQYKQLAENMHTGLPNANYIAFTGTPLLGSKRLTNQWFGDYVSEYNFAQAIEDGSTVRLYYSRRVPEVGLENNWLDSDIDKIVEEEELNDRERELLENSSSRILEVIKRDGRLDRIAQDIAHHFPRRGFLGKGMVVSVDKYTAVKMYEKVQHYWGEEKKALIKERNAAKTQEERDELTARLDYMNKVEMAVIISEEADEVEKFKAQGLDITVHRNKMNEITPEGKDIEDRFKDKDDPLSLVFVCAMWLTGFDVPSLSTLYLDKPMKGHTLMQAIARANRVYPGKSCGIVVDYVNVFKYMQQALSDYASNGEEGAEFPAKDITQLIATIDGCIEECDSFLQGLGIRLDKIITDGDTLDKLESLRLAYDKILEKDESKNRFKVMSNLMMNLHDAAKPEIFELGWKNEKFSPLSYLNGLFCNRIDDEKLRRAKEKMSYTLDDSVTVMVAEDKPQYSIHQSKVIDLSKLDIESIRKSINATPYKSMEIDNLRTFIETALEQLINKNCTRVPFSQRYKNIIDTYNAGGTENEDYYEKLLQLIDELKKEQGRSADMGLREEELEIYDLLIQGRKLTKEEEKEVILASKNLYNKLVEEKERLLVVDWYKDPQPKTKVLGLIQRSLDKDLPKTYDREVFSNKTNLLLDHFVDMAVQGYGWIS
>CP022041|1279773:1354453|1333821_1334337_+|ASE18855.1|DBSCAN-SWA
MILRNTKRIINYCVLMIGLGVWGSCNSKSQHVLLPVDNVKSYKICENNDTTTIFEEREEESEEVIKFYKEGSEIFTSDYGGRKELLMSTTEMLDTVYSGNTYCREHRILIKKENSNLFSTSIYNIIIHPVLVLTIYYDHSYNIKAIRNWFAFTTYESEHISIPLISRPVKY
>CP022041|1279773:1354453|1316250_1317927_+|ASE18846.1|DBSCAN-SWA
MTSTELKDLEGRLWQSADMLRAGAHLAANKYSQPILGLIFLRYADVLFKQHKEAIDTAYNEYKGTRMERSYKDIAIEKCGFFLPECAYFDYLNDAPDDAQKALLVKAAMEAIEHENPRMDGVLPKEVYGQLVPEEEPELLSRIVRVFKDIPENISIDIFGQIYEYFLGNFALAEGQGGGAFYTPASVVQYMVEVLQPATGDKKFLDPACGSGGMFVQAARYMHRHNTSNEQMMNFRCYGVEKEPDTVKLAKMNLLLNNVRGEIMEANSFYSDPYNAVGQFDYVMANPPFNVDEVVVERVTDDARFNTYGVPRNKTKSAKKASDKKETVPNANYLWIGYFATALNEQGKAALVMANSASDAGGSELEIRKKMIEDGIISQMVTLPSNMFSTVTLPATLWFFNKKRPKKDEILFIDARNIFTQVDRAHRKFSDEQVKNLGIISRLYEGDSDAFWALVEEYKAEGKQSEADWLLERWPDGKYQDIVGLCKVAKLEGEDGIIDNDYSLNAGRYVGVVIEDDGMTEEEFRTEMLSLNSEFAKLSAEAKDLESEIEKNLKELLG
>CP022041|1279773:1354453|1293543_1294020_+|ASE18833.1|DBSCAN-SWA
MKLYRGRNHEIPALNTASMPDLIFSILFFFMLVVHMRKANVHVKYQVPMATELSRMYNNSTIQHIYIGRPINSLGQVEGEKMVVQLNDHITTIPEIRKYLIQLSAALPPEQRKELSVSIKADRHADMGTIMDLKQVLREANVLNVNFTATMSRNNKLK
>CP022041|1279773:1354453|1347696_1349757_+|ASE18865.1|DBSCAN-SWA
MIEKEQILLLTQGGLNVFSHFLGFEVNLHRNFRSPFYDDRRASCHIYYDRKTFSYKFYDHGDTTYSEDCFWFVATLRNLNLKTSFPEVLETIVQELGLYSLCNGGKHSSHITSTYKKTIVPTPKADITKCTEEHPYSFEIQPFDDGLLNYWAHYGIHEDTLRRFRVRSLKRYESVSAEGRKFELYSSPTEPMFAYIGNGYVKIYRPHSPKIRFLYGGRMPATYCFGMEQIPAKGDMLFITGGEKDVLSLYAHGFNAICFNSETAQIPTSIIESLQLRFRHIILLYDADETGVREAHKQSEHLVEYKVLNLSLPLSGTKSEKDISDFFALGNGAKELKELLAKMFSDLYSQTMMMLRSCEIDYENPPDISKSVVAVNGVPLGTQDNLFCITGGEGTGKSNYVGAILAGALGEKRLPIEKTLGLEITPNPKGLAVLHYDTEQSEAQLHKNLGKTLRRASLTAVPEFCHSLYLASLSRKDRLNLIRESMDLFHHRHGGIHLVVIDGIADLIRSANDETESIAIVDELYRLAGIYNTCIICVLHFVPNGIKLRGHIGSELQRKAAGILSIEKDDNPEYSVVKALKVRDGSPLDVPMMLFGWDKAEDMHVYRGEKSKEDKEKRKTEELIAVVKEAFRNSFKLTYQELCEVLMREMEIKDRTAKKYIAYMKEQRILAQDTNGNYQKGELCRT
>CP022041|1279773:1354453|1309772_1312529_+|ASE18843.1|DBSCAN-SWA
MRKSIIYLCACALSGMMVTTSCQDNLDSDAGVSNTRSVNIDKDLFAIKGCINVKLAKGTNQAIPTTRSGSVEMQSVPSAMTSAMQYSGAYKMERVFKPAGIYEARTVAEGLDRWYTIYFDKSKDVAAVLDQFKKAEGVECAEQVLPMARPTVKMTPYSPSGASMQATASTFDDPLLAKQWHYYNDGSVNARAKKGADCNVKPVWEKYTTGKKNVIVAVVDGGIDITHEDLKDNLYVNEKEKNGQPNVDDDGNGFVDDIYGYNFVTAKDVVGGTIEPDDGGHGTHVAGTVAARNNNGKGVAGIAGGDGSPDSGVRLLSCQIFRNKDEQGDAAAAIKYAADNGAVICQNSWGYSSTAGVTSMPQLLKEAVDYFIKMAGCDANGNQRPDSPMKGGVVMFAAGNENKEFSAYPACYAPTVSVAAMAWDFSKASYSNYAKWVTITAPGGDQDRFGTEAGVLSTVPKKKVASGYAYFQGTSMACPHVSGIAALIASYFGRQGFTNEELKSRLITAYRPYNIDEQNPTYKGKLGKGYIDAEAAFETDTKIAPEKVGTLTLKPDFVDINAEWSIAKDEDKTAAFYRLYIAQGELTADKLKDMTYREINGMGHSLGETLKYDFDDLKDNTTYSVAVVAVDRWGNLSEPMIQKCTTRLNHAPEATNFPTEAIEVMENDRKSFSFNVADPDGHNWDIKATGETKGVSYTVKGNTVTVNLVPVLEAGSYNCTFILSDDLGAKAEKSFTFKIVKYIPPQLTKPFENYIIGLDEGVVTIPLTGHYTHSGNTQLTYKATAANGSIATATISNDNLQLKGMAKGVTRISIAATDGRETSSDGSFQVRVVEKKSAPVYAVYPIPVQRDIHTLLNPEVKQAELVISSTVGERLMKATVTPDKNNVATLDLSKLNPGTYKLTVYTSKGNHTQMFIKR
>CP022041|1279773:1354453|1308155_1309757_+|ASE18842.1|DBSCAN-SWA
MRIINIHKLLQFSLLYLLLGIAVGCAENDSFDQPYLNVSEKEISFSNQIGEKTITVNTNCKEWMATTPKAWVHLSQSGNEIAVHVDPNTTGMERSSYILVDGGLAVQKIMVSQSAADITLNLNNGEVILPQAGGTTTVDLKMDATSYDLTQSEQPEWMQVIKKKHGLKFISKPNYSTTERTTKLTIAFAGKNHEVVVKQPGVATFILACNPGNPYSLHKMMDYEYRRGSFLTEYGGPDEVNGIFEESYFFKTPSPLFKDVVYVHDTKHSVPTRIYTRSLTREGVNAVKSQAFQEFMRANGYTRDEKDTNHYVNIKEAFTMDVDIREENNSVVLFFYQMHTQDRSYPTFSSLDLGPVDLLNKTDKKISDVEAYETGKNSEEMKRQMSKSNEVEAILYKTNDPTLIARTYFFYLHNDAAVPQEKAGSVEQYSLFYSQPNLGIWQYGNEWFVTHEFDKLLTANNFEFVGYNGKHHVYARRSDYLTLAISGGEYADVNNGKAVMQITVLYKPTVFAGSKEQRLAKVERMLKQYNPKK
>CP022041|1279773:1354453|1337805_1338279_+|ASE18942.1|DBSCAN-SWA
MAKDFNIQTYPTFFLLLLIMLIPFALSVDDIMNNDQSNMKIILLISVFIIIILVYGLVKTRKRKIVINELGLLITEKEGNMKISWEEISHIFFCSTPIWGLYVKITFTNRRDPLIIDFGKSSLWSVNFYRFRIAILAFSHKKDIIVVKSNQWYLKLI
>CP022041|1279773:1354453|1347047_1347404_+|ASE18864.1|DBSCAN-SWA
MIEVNHQLQHYKQKARELLTSEEGIKHRGRRCIEPEAVFGQTKYNKAYKRFRHFGKDKVNMDFAFFAIAFNIGKMCRKTNLKEIKAVMELLLVTFRCCIQVYIGYLKPNKSFYMKLAA
>CP022041|1279773:1354453|1301171_1302782_-|ASE18838.1|DBSCAN-SWA
MAETKYIFVTGGVVSSLGKGIISSSIGKLLQARGYNITIQKFDPYINIDPGTLNPYEHGECYVTEDGMETDLDLGHYERFTGIKTTKANSMTTGRIYKSVIDKERRGDYLGKTIQVVPHITDEIKRNIKLLGQKYHYDFVITEIGGTIGDIESAPFLEAIRQLKWELGKRAINLHLTYVPYLKAAGELKTKPTQHSVKELQSVGIQPDVLVMRTEKHLDDDIRKKVAAFCNVDFDCVVQSEDLPSIYDVPVNMLEQGLDAAILRKCGEEVGPKPALGPWKEFLDRQRKATKEVHIGLVGKYDLQDAYKSIREGLLQAGTYNDRKTVITFINSEELTEENVAEKLKGQDGIVICPGFGQRGIEGKIVAAHYTRTHDIPTFGICLGMQMMVIEFARNVLGYKDANSREIDEKTTHNVIDIMEEQKNITNMGGTMRLGAYECVLRQGSHTFNIYKQEHIQERHRHRYEFNNDYEKEFEKHGMMCVGRNPESDLVEIVEIPGLKWYIGTQFHPEYQSTVLGPHPLFLDFVKTSIENQKNK
>CP022041|1279773:1354453|1303820_1304546_+|ASE18839.1|DBSCAN-SWA
MKKAIVVGASSGIGHEVARLLIAEGWAVGVAARRIDKLTDLQAMAPERVYTVQIDVTNEDAETSLLQLIERMNGIDLYFHAAGIGWQNPSLNADIELKTMETNAVGFTRMIGCAYRYFANKGGGHIACITSIAGTKGLGPAPAYSATKAMQNTYLQALEQLAACKHHNIHFTDIRPGFVDTPLLAGTSHLPMLMTTKKVARSIIKAINSRRHICVIDSRWCVLTYLWRHIPNWIWRRMKLC
>CP022041|1279773:1354453|1353232_1354453_+|ASE18869.1|integrase|DBSCAN-SWA
MKENKLKVSFFVQAKRTDKKGLVPVIGRISVGRTHSGFSTKCKTPLALWDSRKQRLIGKSSMAVSVNQKLGECTALIHARFHELCEREESFTATDVRDAYQGQIHCQALLLESFGEYLTQTKERIGIDRALKTFKLRTYQLSLLREYVQKKHKVSDIPLSQLDKSFIEGFEYYLTIDRRLKRSSISSTLSTLQTIVRIAVKKGALDFYPFLGYSYERPKGEPRSITQEELERIIELKIEWKNYRIVRDLFVFSCFSGLAISDVRNLREENIVLEEGELCIKGRRMKTKTPYRVQVLPPAQTIMNRYRGIRAGFVFDVPTTDVILNGMHYIQRNIGMKTPLTFHMARHTFASLITLSAGVPIETVSRMLGHTNLRTTQVYAAVSSERIHRDMQIVQQRIQDTFTLKL
>CP022041|1279773:1354453|1339055_1339493_+|ASE18859.1|DBSCAN-SWA
MKTDKNIIGVIALHVITFTFVIISWNHSFNSIGFNIVSGISCMLLGGSYLHLELSKYSEEGKVTWFSITHTIIPLIFLLFWAGIALIFYHYIVIMSLLQCLVTSLIPLSFLYLRSKRKENKYITLLLIIISGIFIVLPFIVLSIL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ASE18823.1|1279773_1280643_-|transposase	DDE transposase	NA	NA	NA	NA
ASE18824.1|1280758_1281103_-|transposase	transposase family protein	NA	NA	NA	NA
ASE18825.1|1281625_1282603_+	DUF4974 domain-containing protein	NA	NA	NA	NA
ASE18826.1|1282677_1285737_+	DUF4981 domain-containing protein	L0N6M2	Herpes_simplex_virus	1.3e-152	33.6
ASE18827.1|1286245_1287136_-	RluA family pseudouridine synthase	NA	NA	NA	NA
ASE18828.1|1287270_1287804_-	HDIG domain-containing protein	NA	NA	NA	NA
ASE18829.1|1287893_1289672_-	oxaloacetate decarboxylase	NA	NA	NA	NA
ASE18830.1|1289813_1290629_+	hypothetical protein	NA	NA	NA	NA
ASE18831.1|1291368_1292202_+	MotA/TolQ/ExbB proton channel family protein	NA	NA	NA	NA
ASE18938.1|1292489_1293005_+	hypothetical protein	NA	NA	NA	NA
ASE18832.1|1293001_1293547_+	biopolymer transporter ExbD	NA	NA	NA	NA
ASE18833.1|1293543_1294020_+	biopolymer transporter ExbD	NA	NA	NA	NA
ASE18834.1|1294115_1294625_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
ASE18835.1|1295266_1296889_-	MFS transporter	NA	NA	NA	NA
ASE18836.1|1297077_1299237_-	S9 family peptidase	NA	NA	NA	NA
ASE18837.1|1299239_1301171_-	membrane protein insertase YidC	NA	NA	NA	NA
ASE18838.1|1301171_1302782_-	CTP synthase	A0A1J0FA14	Only_Syngen_Nebraska_virus	2.2e-132	47.2
ASE18939.1|1303578_1303824_+	hypothetical protein	NA	NA	NA	NA
ASE18839.1|1303820_1304546_+	KR domain-containing protein	NA	NA	NA	NA
ASE18840.1|1304752_1305565_+	PepSY domain-containing protein	NA	NA	NA	NA
ASE18841.1|1306499_1308119_+	hypothetical protein	NA	NA	NA	NA
ASE18842.1|1308155_1309757_+	hypothetical protein	NA	NA	NA	NA
ASE18843.1|1309772_1312529_+	T9SS C-terminal target domain-containing protein	A0A1B0T6A2	Bacillus_phage	3.9e-20	28.9
ASE18844.1|1312540_1313494_+	hypothetical protein	NA	NA	NA	NA
ASE18845.1|1313538_1315113_+	hypothetical protein	NA	NA	NA	NA
ASE18846.1|1316250_1317927_+	N-6 DNA methylase	A0A2H4PQP4	Staphylococcus_phage	8.4e-34	25.7
ASE18847.1|1317940_1319164_+	restriction endonuclease subunit S	NA	NA	NA	NA
ASE18848.1|1319179_1322380_+	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	7.6e-68	29.1
ASE18849.1|1322765_1323911_-	DUF1735 domain-containing protein	NA	NA	NA	NA
ASE18850.1|1323951_1325070_-	endoglycosidase	NA	NA	NA	NA
ASE18940.1|1325087_1326713_-	SusD/RagB family nutrient-binding outer membrane lipoprotein	NA	NA	NA	NA
ASE18851.1|1326719_1329830_-	SusC/RagA family TonB-linked outer membrane protein	NA	NA	NA	NA
ASE18852.1|1330183_1331287_-	MRP family ATP-binding protein	NA	NA	NA	NA
ASE18853.1|1331417_1331795_-	hypothetical protein	NA	NA	NA	NA
ASE18854.1|1333136_1333403_+	hypothetical protein	NA	NA	NA	NA
ASE18855.1|1333821_1334337_+	hypothetical protein	NA	NA	NA	NA
ASE18856.1|1335329_1335629_+	hypothetical protein	NA	NA	NA	NA
ASE18857.1|1335636_1335981_+	hypothetical protein	NA	NA	NA	NA
ASE18941.1|1336116_1336590_+	hypothetical protein	NA	NA	NA	NA
1337644:1337658	attL	NA	NA	NA	NA
ASE18942.1|1337805_1338279_+	hypothetical protein	NA	NA	NA	NA
ASE18858.1|1338541_1339069_+	hypothetical protein	NA	NA	NA	NA
ASE18859.1|1339055_1339493_+	hypothetical protein	NA	NA	NA	NA
ASE18860.1|1341252_1341597_-|transposase	transposase family protein	NA	NA	NA	NA
ASE18861.1|1341802_1343464_-|transposase	IS5/IS1182 family transposase	A0A146ICT8	Staphylococcus_phage	5.2e-60	32.7
ASE18862.1|1343804_1344602_+	phosphatidylserine synthase	NA	NA	NA	NA
ASE18863.1|1345736_1346954_+|transposase	IS4 family transposase	NA	NA	NA	NA
ASE18864.1|1347047_1347404_+	hypothetical protein	NA	NA	NA	NA
ASE18865.1|1347696_1349757_+	bifunctional DNA primase/helicase	NA	NA	NA	NA
ASE18866.1|1349744_1350053_+	DNA-binding protein	NA	NA	NA	NA
ASE18867.1|1350429_1351362_+	abortive phage resistance protein	A0A059NT88	Lactococcus_phage	1.4e-14	25.4
ASE18868.1|1351403_1352921_-	helicase	A0A248SL14	Klebsiella_phage	4.3e-37	28.9
ASE18869.1|1353232_1354453_+|integrase	site-specific integrase	H7BUI8	unidentified_phage	2.2e-23	31.1
1366005:1366019	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage
CP022041.2|ASE18007.1|74110_74530_-|PcfK-like-protein	74110_74530_-	139 aa aa	40	NA	NA	No	NA
CP022041.2|ASE18124.1|255433_255853_+|PcfK-like-protein	255433_255853_+	139 aa aa	40	NA	NA	No	NA

Protein sequences of CP022041.2|ASE18007.1|74110_74530_-|PcfK-like-protein

>CP022041.2|ASE18007.1|74110_74530_-|PcfK-like-protein
MKGTEHFTRTIAEYLNQRAMTDPLFAPNLLKPNKNIEECITYILNEVQKSGCNGFDDDEIFSMAVHYYDEDDIEVGKAISCQVAVNHIVELTEEEKAEARQEAIKQYQREELAKIQSRNARVKKTENATTQVQPSLFDF

gnl|BL_ORD_ID|40 information

• hit_Aca_id: gnl|BL_ORD_ID|40
• identity: 0.6099290780141844
• query_coverage: 1
• hit_coverage: 1.0

Protein sequences of CP022041.2|ASE18124.1|255433_255853_+|PcfK-like-protein

>CP022041.2|ASE18124.1|255433_255853_+|PcfK-like-protein
MKGTEHFTRTIAEYLNQRAMTDPLFAPNLMKPNKNIEECITYILNEVQKSGCNGFDDDEIFSMAVHYYDEDDIEVGKAISCQVAVNHIVELTEEEKAEARQEAIKQYQREELAKLQSRNARVKKTENIATQVQPSLFDF

gnl|BL_ORD_ID|40 information

• hit_Aca_id: gnl|BL_ORD_ID|40
• identity: 0.6028368794326241
• query_coverage: 1
• hit_coverage: 1.0

2. CP022040

CRISPR-Cas detection and classification

Crispr_ID: CP022040_1

• CRISPR_ID: CP022040_1
• CRISPR_location: 75267-75356
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: RT

Consensus repeat of CP022040_1

Consensus_repeat	Method
CCTCCAATAAGATGGTTTTATAAA	CRISPRCasFinder

spacers of CP022040_1

>1.1|75291|42|CP022040|CRISPRCasFinder
GGCTCAACACCCAACACCCATCACCCAACACCGGTATAATTG

CRISPR arrays and Neighbor proteins around CP022040_1

CRISPR arrays

The CRISPR arrays of CP022040_1

>merge|CP022040|1|75267-75356|CRISPRCasFinder
CCTCCAATAAGATGGTTTTATAAAGGCTCAACACCCAACACCCATCACCCAACACCGGTATAATTGCCCCCAATAAGATGGTTTTATAAA

>CP022040|1|1|75267-75356|CRISPRCasFinder
CCTCCAATAAGATGGTTTTATAAA	GGCTCAACACCCAACACCCATCACCCAACACCGGTATAATTG
CCCCCAATAAGATGGTTTTATAAA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022040.2|ASE16662.1|84326_84944_-|hypothetical-protein	unknown	unknown	unknown
CP022040.2|ASE16649.1|67496_68600_+|redox-regulated-ATPase-YchF	unknown	unknown	gnl|CDD|236583
CP022040.2|ASE16656.1|77585_78179_-|chorismate-binding-protein	unknown	unknown	gnl|CDD|235934
CP022040.2|ASE16651.1|70091_70508_+|hypothetical-protein	unknown	unknown	unknown
CP022040.2|ASE16652.1|70701_73362_+|DNA-mismatch-repair-protein-MutS	unknown	unknown	gnl|CDD|235444
CP022040.2|ASE16655.1|76097_77423_+|RNA-directed-DNA-polymerase	RT	pfam00078_RT_CAS-I:CAS-III	gnl|CDD|239569
CP022040.2|ASE16658.1|79193_79835_-|semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|187560
CP022040.2|ASE16647.1|64435_65482_+|ribonucleotide-diphosphate-reductase-subunit-beta	unknown	unknown	gnl|CDD|236591
CP022040.2|ASE16648.1|66383_67193_+|DUF3108-domain-containing-protein	unknown	unknown	gnl|CDD|378635
CP022040.2|ASE16660.1|81595_83524_-|4-hydroxy-3-methylbut-2-en-1-yl-diphosphate-synthase	unknown	unknown	gnl|CDD|179361
CP022040.2|ASE16663.1|84984_86499_-|RNA-polymerase-sigma-54-factor	unknown	unknown	gnl|CDD|274109
CP022040.2|ASE16654.1|74567_75062_-|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
CP022040.2|ASE16659.1|80075_81134_-|sensor-histidine-kinase	unknown	unknown	gnl|CDD|377675
CP022040.2|ASE16664.1|86545_87196_-|hypothetical-protein	unknown	unknown	unknown
CP022040.2|ASE16653.1|73823_74447_-|hypothetical-protein	unknown	unknown	unknown
CP022040.2|ASE16657.1|78162_79152_-|aminodeoxychorismate-synthase-component-I	unknown	unknown	gnl|CDD|235932
CP022040.2|ASE16661.1|83691_84198_-|5-(carboxyamino)imidazole-ribonucleotide-mutase	unknown	unknown	gnl|CDD|376377
CP022040.2|ASE16650.1|68672_69515_+|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl|CDD|234599
CP022040.2|ASE16646.1|61694_64214_+|ribonucleoside-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl|CDD|237077
CP022040.2|ASE16645.1|60712_61333_+|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP022040.2|ASE16655.1|76097_77423_+|RNA-directed-DNA-polymerase	RT	pfam00078_RT_CAS-I:CAS-III	2.7e-25	84.0	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022040.2|ASE16648.1|66383_67193_+|DUF3108-domain-containing-protein	gnl|CDD|378635	pfam11306, DUF3108, Protein of unknown function (DUF3108). This is a bacterial family of putative lipoproteins. Structure 3fzx, the first structural template for this large family including several homologs in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Bacteroides fragilis glyA is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA|QNQDC, and a Phobius server prediction of non-cytoplasmic localization for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit Structure 2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.	8.7468e-59
CP022040.2|ASE16652.1|70701_73362_+|DNA-mismatch-repair-protein-MutS	gnl|CDD|235444	PRK05399, PRK05399, DNA mismatch repair protein MutS; Provisional.	0
CP022040.2|ASE16649.1|67496_68600_+|redox-regulated-ATPase-YchF	gnl|CDD|236583	PRK09601, PRK09601, redox-regulated ATPase YchF.	0
CP022040.2|ASE16658.1|79193_79835_-|semialdehyde-dehydrogenase	gnl|CDD|187560	cd05250, CC3_like_SDR_a, CC3(TIP30)-like, atypical (a) SDRs. Atypical SDRs in this subgroup include CC3 (also known as TIP30) which is implicated in tumor suppression. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine rich NAD(P)-binding motif that resembles the extended SDRs, and have an active site triad of the SDRs (YXXXK and upstream Ser), although the upstream Asn of the usual SDR active site is substituted with Asp. For CC3, the Tyr of the triad is displaced compared to the usual SDRs and the protein is monomeric, both these observations suggest that the usual SDR catalytic activity is not present. NADP appears to serve an important role as a ligand, and may be important in the interaction with other macromolecules. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.05939e-59
CP022040.2|ASE16647.1|64435_65482_+|ribonucleotide-diphosphate-reductase-subunit-beta	gnl|CDD|236591	PRK09614, nrdF, ribonucleotide-diphosphate reductase subunit beta; Reviewed.	2.90118e-140
CP022040.2|ASE16656.1|77585_78179_-|chorismate-binding-protein	gnl|CDD|235934	PRK07101, PRK07101, hypothetical protein; Provisional.	1.50657e-72
CP022040.2|ASE16663.1|84984_86499_-|RNA-polymerase-sigma-54-factor	gnl|CDD|274109	TIGR02395, RNA_polymerase_sigma-54_factor, RNA polymerase sigma-54 factor. A sigma factor is a DNA-binding protein protein that binds to the DNA-directed RNA polymerase core to produce the holoenzyme capable of initiating transcription at specific sites. Different sigma factors act in vegetative growth, heat shock, extracytoplasmic functions (ECF), etc. This model represents the clade of sigma factors called sigma-54, or RpoN (unrelated to sigma 70-type factors such as RpoD/SigA). RpoN is responsible for enhancer-dependent transcription, and its presence characteristically is associated with varied panels of activators, most of which are enhancer-binding proteins (but see Brahmachary, et al., ). RpoN may be responsible for transcription of nitrogen fixation genes, flagellins, pilins, etc., and synonyms for the gene symbol rpoN, such as ntrA, reflect these observations [Transcription, Transcription factors].	1.39097e-112
CP022040.2|ASE16654.1|74567_75062_-|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	4.26965e-32
CP022040.2|ASE16659.1|80075_81134_-|sensor-histidine-kinase	gnl|CDD|377675	pfam06580, His_kinase, Histidine kinase. This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.	4.46464e-25
CP022040.2|ASE16657.1|78162_79152_-|aminodeoxychorismate-synthase-component-I	gnl|CDD|235932	PRK07093, PRK07093, para-aminobenzoate synthase component I; Validated.	0
CP022040.2|ASE16661.1|83691_84198_-|5-(carboxyamino)imidazole-ribonucleotide-mutase	gnl|CDD|376377	pfam00731, AIRC, AIR carboxylase. Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	3.10683e-80
CP022040.2|ASE16650.1|68672_69515_+|prolipoprotein-diacylglyceryl-transferase	gnl|CDD|234599	PRK00052, PRK00052, prolipoprotein diacylglyceryl transferase; Reviewed.	3.59555e-74
CP022040.2|ASE16646.1|61694_64214_+|ribonucleoside-diphosphate-reductase-subunit-alpha	gnl|CDD|237077	PRK12364, PRK12364, ribonucleoside-diphosphate reductase subunit alpha.	0
CP022040.2|ASE16655.1|76097_77423_+|RNA-directed-DNA-polymerase	gnl|CDD|239569	cd03487, RT_Bac_retron_II, RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA branches out from a small ssRNA molecule via a 2'-5'phosphodiester linkage. Bacterial retron RTs produce cDNA corresponding to only a small portion of the retron genome.	1.84642e-72
CP022040.2|ASE16660.1|81595_83524_-|4-hydroxy-3-methylbut-2-en-1-yl-diphosphate-synthase	gnl|CDD|179361	PRK02048, PRK02048, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional.	0

Protein sequences

>CP022040.2|ASE16654.1|74567_75062_-|sigma-70-family-RNA-polymerase-sigma-factor
MDNLQNEQDFSRIVREHKSTIYTVCYMFSKDEDEVNDLFQEVLINLWKGLQNFRGESDVRTWIYRISLNTCISCDRKKRKRKTIPLSMNINPFTDSDDDSRQIQQLNRRISQLGPFDRAIILLWLENMSYEEIGEIVGISTKNVSVRLFRIKEKLKKTSETTKE
>CP022040.2|ASE16653.1|73823_74447_-|hypothetical-protein
METKHTEFEEMRQQLDILKNKLDNQTLINDKLIRQSMLNKMSFMKKYTWVSFLVLLFIYYVYNDIRITFNLSWWFYGATVIFMTFTVCFDAYINRFNKEAFLNGDLIATSLQMQRMKKLRKRSLLYGIFFMTIWVSWFVIELYNGSGAANGGENTSMFYGILVGGGVGLIAGVAIGIWLYLRMQRINSDIISQIDELTKDTKDSPIL
>CP022040.2|ASE16652.1|70701_73362_+|DNA-mismatch-repair-protein-MutS
MAKDDKGLTPMMKQFFSMKAQHPGALMLFRCGDFYETYGEDAVESARILGITLTRRNNGGNGDSIEMAGFPHHALDTYLPKLIRAGKRVAICDQLEDPKKKREAIKGKKGLSAMDKMVKRGITELVTPGVAMSDNVLNYKENNFLAAVHFGKGSCGVSFLDISTGEFLTGEGTFDYVEKLLGNFQPKEVLFDRAKKQDFERYFGTRLCTFEMDDWVFTDQTARQKLLKHFGTKNLKGFGVDHLNNGVVAAGAILQYLEITQHTQINHITSLARIEEDKYVRMDRFTIRSLELIAPMNEDGSSLLNVIDNTITPMGGRMLRRWMVFPLKDEKPINERLDVVDYLFREPDFRECINEQFHRIGDLERIISKVAVGRVSPREVVQLKNALMAIQPVKTVCLYTKSDTLKRIGEQLNLCESLRDRIEKEIQPDPPQLVNKGDVIALGFNQELDDLRSIRDNGKQYLLEIQEKEIAQTGITSLKIGFNNVFGYYLEVRNTFKDKVPENWIRKQTLAQAERYITPELKEYEEKILGADEKILALETQLYMELIQDMQEFIPQIQINANLIAHLDCLLSFMKVSQLQRYVRPVVDDSEVIDIKQGRHPVIETQLPIGEQYVPNDVLLDTEHQQIMMITGPNMAGKSALLRQTALIVLLAQIGCFVPAERARIGMVDKIFTRVGASDNISLGESTFMVEMTEASNILNNVTPRSLVLFDELGRGTSTYDGISIAWAIVEYLHEHSRAQARTLFATHYHELNEMEKNFPRIKNFNVSVKQVDGKIIFVRKLEKGGSEHSFGIHVAEIAGMPRSIVKRANVILKELEKDNSQVGSVGKAAVERLDQSREGVQLSFFQLDDPVLTQIRDEILGLDVNNLTPVEALNKLNDIKKIVKG
>CP022040.2|ASE16651.1|70091_70508_+|hypothetical-protein
MYKIITQLKIMKKYLLILLALLPMMLFTACSSDKEEETSNNLVGTTWQYLEKEGNKITSMTVLEFKSNTVVKIITDEDLDKNPTERDHDEGDATYVLNGKKISIKRDIYTAWGEVDGDKLTLQYVDDGEIITMIFTKR
>CP022040.2|ASE16650.1|68672_69515_+|prolipoprotein-diacylglyceryl-transferase
MNNLLYIAWQPSEVIFQLGSLPIRWYGMCWLVGLALGYFMMQWLFKRHKFPPSQFDPLFLYVFFGVLIGARLGHCLFYEPEEFLTSWKGIMTIFIPIREMADGSWKYVGYQGLASHGGVAGLLIALFLYIRRTKMNTWVVLDFFGIVSGITACFIRLGNLMNSEIIGKVTDVPWAFIFYNVDDKPRHPGQLYEAIAYLIIFLLIYFIYRKYPKKVGTGLYFGLCLTLIFTFRFFIEYTKEIQEAFEAGLPIDMGQILSIPLIALGVWSILRSRGKEGKLP
>CP022040.2|ASE16649.1|67496_68600_+|redox-regulated-ATPase-YchF
MALKCGIVGLPNVGKSTLFNCLSSAKAQAANFPFCTIEPNLGVITVPDERLNKLAEIVHPGRIVPATCEIVDIAGLVKGASKGEGLGNKFLGNIRECDAIIHVIRCFEDDNVVREGGMAVNPIEDKEIIDTELQLKDLETIEAQLAKQQKVAAAGNKDAKVMVSVLEAYKEVLEQGKNARSVEFESKEEQQAAHDLFLLTTKPVLYVCNVDESSAKTGNEYSQMIEKIAAEEGAEAMIIAAKTEEDIASLESYEDKKMFLDELGLEESGVSRLINKAYHLLNLQTFITAGEMEVKAWTFHKGWKAPQCAGVIHTDFEKGFIRAEVIKYDDYIKYGSEAAIREAGKLGIEGKEYVVQDGDIMHFRFNV
>CP022040.2|ASE16648.1|66383_67193_+|DUF3108-domain-containing-protein
MKKFKIYIVCLFAMIAVSTTAQCTFRNTAFSSGEYLTYNLYYNWKFIWVKAGTASWYTVSSTYKGIPAYRASLTTRGNGKLDDYFVLRDTLLTYNSKQMEPLYFRKGAREGKRYTVDEIFYTYPNGKCKLRQHRINNEGKHQWMENTYDDCCFDMMSIFLRARSFNPENWKKGEVVKFPIVDGNSRHAGRIVYGGKENIKADNNHKYRCLRLTYYEYEDDKWREIANFYVTDDSNHIPVRLDMSLKFGSAKAFLVSMKGINSPITSEVK
>CP022040.2|ASE16647.1|64435_65482_+|ribonucleotide-diphosphate-reductase-subunit-beta
MDNQLKRNTLFNPSGDIELRLRRMIGGNTTNLNDFNNMKYSWVSDWYRQAMNNFWIPEEINLSQDFKDYPRLEKAERTAYDKILSFLVFLDSLQSNNLPTLSEYITANEVNLCLHIQAFQECIHSQSYSYMLDTICSPEERNDILYQWKTDEHLLNRNKFIGDCYNEFHEKRDKFSLMKTLIANFILEGIYFYSGFMFFYNLSRNGKMSGSAQEIRYINRDENTHLWLFRSIILELKKEEPDMFTPEKIKVYEDMMREGVRQEIAWGQYVIGNDVQGLNAQMVSDYIRYLGNLRWSGLGFGFLYDDNQKEPENMKWVGQYSNANMVKTDFFEAKSTAYAKSTALIDDL
>CP022040.2|ASE16646.1|61694_64214_+|ribonucleoside-diphosphate-reductase-subunit-alpha
MNITKRNGEVEVYNNEKISIAIKKSFISTGKDISDNEIAGMVSEVEQFIKENPELRTVEDIQNRVEKCLMAHGHYDEAKNYILFRYQRNEQRQAINYIVWTADDRELADVLHSVAREYRERSYSMVTLQEKFSSFTKPGMSQKDSIDALIKAAVELTTPEAPAWEMISARILSYRSEKKITRLEEELGLKTFYRKVKYMTEEGLYGDYILQNYSEEEINEAATFIDPERNKLLNYSGLDLLLKRYVIKNYSGKVIERVQEMFLGIALHLAMPEKEDRLMWVRRIYDLLSKLEVTMATPTLSNSRKPSHQLSSCFIDTVPDSLDGIYRSLDNFSQVSKFGGGMGMYFGKVRATGGNIRGFKGVAGGVIRWMRLVNDTAVAVDQLGMRQGAVAVYLDVWHKDLPEFLQLRTNNGDDRMKAHDIFPAICYPDLFWKMAEEDMNQNWSLFCPNEIMRIKGYCLEDCYGEEWERKYLDCVNDQRLSRRVISIKDIVRLVLRSAVETGTPFTFNRDTVNRANPNAHKGMIYCSNLCTEIAQNMAPIETVSKEVETKDGDTVVVTTTRPGEFVVCNLASLSLGRLPLEDEEKMKEKVATVVRALDNVINLNFYPVPYAQLTNQRYRSIGLGISGYHHALAKRRIKWESEEHLEFMDKVFETINRAAILASSNLAKEKGSYQFFEGSDWQTGTYFDKRGYDSAEWQDVRKTVALQGMRNAYLLAVAPTSSTSIIAGTTAGLDPIMKRFFLEEKKGSMLPRVAPELSDETYWMYKSAYLINQKWSVRASGVRQRHIDQAQSMNLYITNDFTMRQILDLYLLAWKEGVKTIYYVRSKSLEVEECESCSS
>CP022040.2|ASE16645.1|60712_61333_+|hypothetical-protein
MKQTALFFVFLLTLLSSCCTKTCQKTTESNALDSLVLVDTTEMKSAFLGCIHRFIKQYPKDSTFILKCGYGYEDHGVYTNGVYINSDVFVIQPAYYDMFMGGEWSIDDMYPSHYFKIDNRIVFLCSRSDSFMKQEKYRKAYSQIVSDSLRVHYEDFAFILVEHKDNKATLLSSEEMRKRKISPISGFRTVVKFKAPKLTDESSDDE
>CP022040.2|ASE16655.1|76097_77423_+|RNA-directed-DNA-polymerase
MATRTINGREYTKVDFENKLRHLSDAQELAAMLNELKLPWYYSDFRGKQLSFLADTNNVQRRCKTFRLRKKHGGYREITAPKGSLRGILNALNILLQTYDEPTPWAFGFVCGRSVVDNARPHVGKRYILNLDLKDFFPTITRQQVADCLTAEPFGFSSLAVKLISGLATVRTKNNKEVLAQGFATSPTLSNFICREMDKEIAGVAAAQGITFTRYADDLTFSSDTDILRPQGELVQQVKAIVERYGFRLNEEKTHLQRRGRRQEVTGLMVTEKVNVSRRYVREIRSLLYIWERYGYEDACQAAWKSYRQQHGKTKGHQHCVPLNAVLRGKLNYMKMVRGADDPLYQRFVSRYTSLQQRSKGDIKEVAYKAYMGKYLSNSTEDRMTSANVLPNDNTSSRQLGATSSNPYDPRKKSKRILNFIVMVIILVAIILIKLFLKSLL
>CP022040.2|ASE16656.1|77585_78179_-|chorismate-binding-protein
MCQYIETIRVIDGCVCNLAYHEERLNRTRKEMLGLTEPLHIADLLKAVSLPMECSKLRFVYDKEGIHDITCTPYICKEINSLHLVYDNNISYPFKSTDRSALNELKKQQGDCDEILIVRDNHLTDTSYTNIALYDGEQWFTPSTPLLCGTMRQRLLDCGLLQEREIMVSDIPNYQYISLFNAMISLGEVILPVDKIK
>CP022040.2|ASE16657.1|78162_79152_-|aminodeoxychorismate-synthase-component-I
MILYDREHAIQRMNTLAKEGKDFIFIINYKADGAYIEEVADINPHELLFAFPSLSNIPEGESYSNEAVEWHTEPLTRDDYEQRINLVKQREREGDSYLANLTCKIPVRTNLSLHDIFMRSKALYRCWMKEKFVCFSPEIFVRINKEGLISSFPMKGTIDATRPEAEKELMENKKEAAEHATIVDLIRNDLSIIAEQVQVKRYRYIDHLTTNKGEILQTSSEITGQLPTDYRENIGTLLFHLLPAGSITGAPKPRTMEIIDEAEGYERDFYTGVMGCYSKGQLDSAVMIRFIDQDKDGQLHYKAGGGITAQSNNDDEYKEVIEKVYVPIY
>CP022040.2|ASE16658.1|79193_79835_-|semialdehyde-dehydrogenase
MRAIILGATGAIGKDLVQELINDDTIEQIAIFVRRDPGINNEKVTTHIVDFDQSDEWRLSVQGDVVFSCMGTTRKAAGSKENQYKIDYTYQYNFAKIAAEQGVPSFILVSAAMANANSHFFYTKMKGELEEAIKQLPFQHISILRPPALIRKNTTRSSEKLSVSILHFFNKIGLLQSQRPMKTEVVAHCMVELAKTKKSGVFEPKDIFKIGER
>CP022040.2|ASE16659.1|80075_81134_-|sensor-histidine-kinase
MKVLEDIKKYCLSRYNLSVLGAQVGIYALLVSIWSLVIMLLEHDVNAAKESMCVNAFVLFLLLIVFMANFYVLVPYLFEAKNKIKHWAFWVINLLFIVLWNHHIFSIYNADLPNAPIRIGFYQFGVMWMILNYAMVVAAIFVRYYIRHSTLRRQLREEKQKMTEAELAWLKNQLNPHFLFNTLNNIASLTQTSPNNAQKAIGQLSELLRYALYETQPKEVSLNGEIAFIKNYINLMTLRSGSNVEIKSQFIIHNTQLLIAPLVFLTPVENAFKHGISANKPSFIHISITEDNGKIVFLCENSNYPKNDTDKSGKGIGLENMYRRLELIYPDRYHIEQRITPEVYHLKIIIKP
>CP022040.2|ASE16660.1|81595_83524_-|4-hydroxy-3-methylbut-2-en-1-yl-diphosphate-synthase
MIDLFNFERRKTSVTHVGALNIGGENPVRVQSMTTTSTDDTEGSVAQAKRIIDAGGELVRLTTQGKREAENLKNINAQLRADNYMAPLCADVHFNANVADVAALYAEKVRINPGNYVDPARTFKKLEYTDEEYAQELQKIEDRLIPFINICKENHTAVRIGVNHGSLSDRIRNRYGDTPEGIVESCMEFLRIFRKYDFHDIVISIKSSNTVVMVRSVRLLVAEMDKEGMHYPLHLGVTEAGEGEDGRIKSAVGIGALLADGIGDTIRVSLSEEPECEIPVAKHLTWYIRRHEKHHLIPAEQYDGFDYLHPNRRETVAAGNIGGENVPVVIATRKADQATAEVSSPELPKPDYIYVQGELPEKRAKKQKYILDYDAYMNLANSGKQSLENVYPIFPVTGMPFISAINSDVKFLVLKFGTPSEEFLACLKAHPEVVVVCMTSHQNRLGDQRALAHQLMIAGVKNPIIFAQMYQHSTTEEKEESSNSQQAETTTAKEKFQLEAAADMGALMMDGLTDGIWLMNNGNLSQEDVEQTAFGILQAGRLRMVKTEYISCPGCGRTLYDLRTTIARIKEATKGMKGLKVGIMGCIVNGPGEMADADYGYVGAGPKKVSLYRKQVCVEHNIPEEEAVERLLALIKADQNKA
>CP022040.2|ASE16661.1|83691_84198_-|5-(carboxyamino)imidazole-ribonucleotide-mutase
MKPLVSIIMGSTSDLPVMEKACKWLEEQEIPFEVNALSAHRTPDAVETFAKEAKGRGVKVIIAAAGMAAALPGVIAASTPLPVIGVPIKGMLDGLDALLSIVQMPPGIPVATVGVNGAQNAAILAAEMIALGDEAIAKKIDNWKASLGQKIEKANKELAELKDYKFKC
>CP022040.2|ASE16662.1|84326_84944_-|hypothetical-protein
MNEKNIILTARVVSMVLTPFYLPVVGILAIFTFSYLSMFPWQAKLSYVFLVYAFTVLIPTLLIHLYRQYHGWTLIQLGQRERRMVPYVISILCYFTCFYIMNILHLPHMLTSILMVALIIQILCAIINVWWKISTHTAAIGGVTGSLIAFSLLFNFNPMWWLCLTLIVSGFVGSSRMILRQHSLEQVASGFFLGIICSFITIIVV
>CP022040.2|ASE16663.1|84984_86499_-|RNA-polymerase-sigma-54-factor
MAQEQVQIQTQKQQQVQRLSQQQMLQVKLLEMPLTELEESVNAELDDNPALEAGGEETDSIDDNDTVEHSEDDDFDTLQEREERQDALDSALERMRSDDDLPTYDSRQQRNNAEYEEIVYGDTTSFIDKLNEQVGERELTERQKSILEYLIGSLDDDGLLRKDLDSISDELAIYYGIDASTKELEEVLKILQDFDPAGIGARDLQECLLLQIDRKVENGEWEKDSHLYKYIYNILSHHFDAFKKKHWDKIQSALSLSDLQVEALQREIRKLNPKPGSSMGETQGRNLQQITPDFIIDTEDDGTVTFSLNHGNLPELHVSQTFNDMMETYRNNKANMNRQEKEALLYAKEKVEKAQGFIEAVKQRRHTLQVTMKAIIDIQRKFFQDGDEADLKPMILKDIADRTGLDISTISRVSNIKYAQTRWGTFPLRFFFTDSYTTEDGEEMSTRKIKLALKEVIDKEDKRKPLSDDALAKVMKEKGFPIARRTVAKYREQLGLPVARLRKE
>CP022040.2|ASE16664.1|86545_87196_-|hypothetical-protein
MATHPLWSDDYWLLLLQLYLKKPEGMKPMYSRALVDLSLELHIPPKNLYEQLFKLRHRDMPIINLIWETYGENTRKLNKDVKKLRSMKGFGQPKKFYDGVKVRETFEHDFLPVEGGATELKPFMLIMILDLYFRLTPITMAAETPEVIDLAKLMKIKPQMIVEVMDVFQLCDPYLNRDDLLISPLLMPCQEVWNRYGNDNPEKLSALAAQLKEYFT

Crispr_ID: CP022040_2

• CRISPR_ID: CP022040_2
• CRISPR_location: 1282211-1282327
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022040_2

Consensus_repeat	Method
TTTGAATCCCAACGGAGTCACAAAAAGTG	CRISPRCasFinder

spacers of CP022040_2

>2.1|1282240|59|CP022040|CRISPRCasFinder
ACAACTTTCTGATGACATTTAGCTGAATGAGGTTAGAAAAATGTTCTGAAGGTCTTGGA

CRISPR arrays and Neighbor proteins around CP022040_2

CRISPR arrays

The CRISPR arrays of CP022040_2

>merge|CP022040|2|1282211-1282327|CRISPRCasFinder
TTTGAATCCCAACGGAGTCACAAAAAGTGACAACTTTCTGATGACATTTAGCTGAATGAGGTTAGAAAAATGTTCTGAAGGTCTTGGATTTGAATCCCAACGGAGTCACGAAAAAGT

>CP022040|2|2|1282211-1282327|CRISPRCasFinder
TTTGAATCCCAACGGAGTCACAAAAAGTG	ACAACTTTCTGATGACATTTAGCTGAATGAGGTTAGAAAAATGTTCTGAAGGTCTTGGA
TTTGAATCCCAACGGAGTCACGAAAAAGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022040.2|ASE17518.1|1278327_1279212_+|acyltransferase	unknown	unknown	gnl|CDD|143597
CP022040.2|ASE17521.1|1282573_1283761_+|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl|CDD|366058
CP022040.2|ASE17530.1|1296217_1297393_-|PLP-dependent-transferase	unknown	unknown	gnl|CDD|223699
CP022040.2|ASE17516.1|1275942_1276221_-|hypothetical-protein	unknown	unknown	gnl|CDD|377375
CP022040.2|ASE17527.1|1293280_1294102_+|hypothetical-protein	unknown	unknown	gnl|CDD|224495
CP022040.2|ASE17519.1|1279753_1280140_+|hypothetical-protein	unknown	unknown	unknown
CP022040.2|ASE17529.1|1295039_1296221_-|putative-C-S-lyase	unknown	unknown	gnl|CDD|275146
CP022040.2|ASE17514.1|1274303_1275050_+|peptidylprolyl-isomerase	unknown	unknown	gnl|CDD|365914
CP022040.2|ASE17525.1|1291296_1292217_+|hypothetical-protein	unknown	unknown	unknown
CP022040.2|ASE17513.1|1273406_1274216_+|molecular-chaperone-DjlA	unknown	unknown	gnl|CDD|236512
CP022040.2|ASE17515.1|1275155_1275497_-|TM2-domain-containing-protein	unknown	unknown	gnl|CDD|377473
CP022040.2|ASE17528.1|1294511_1295027_-|diguanylate-cyclase	unknown	unknown	gnl|CDD|380313
CP022040.2|ASE17517.1|1277172_1278240_+|agmatine-deiminase-family-protein	unknown	unknown	gnl|CDD|377332
CP022040.2|ASE17526.1|1292303_1293119_+|Nif3-like-dinuclear-metal-center-hexameric-protein	unknown	unknown	gnl|CDD|376614
CP022040.2|ASE17937.1|1275557_1275926_-|DUF2752-domain-containing-protein	unknown	unknown	gnl|CDD|378499
CP022040.2|ASE17520.1|1280838_1281876_-|aspartate--ammonia-ligase	unknown	unknown	gnl|CDD|235456
CP022040.2|ASE17523.1|1285526_1287797_+|sodium:proton-antiporter	unknown	unknown	gnl|CDD|223551
CP022040.2|ASE17524.1|1288239_1290954_-|DUF2726-domain-containing-protein	unknown	unknown	gnl|CDD|350195
CP022040.2|ASE17512.1|1272818_1273268_+|hypothetical-protein	unknown	unknown	gnl|CDD|372640
CP022040.2|ASE17522.1|1284085_1285309_+|peptidase-T	unknown	unknown	gnl|CDD|235484

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022040.2|ASE17518.1|1278327_1279212_+|acyltransferase	gnl|CDD|143597	cd07573, CPA, N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases). CPA (EC 3.5.1.53, also known as N-carbamoylputrescine amidase and carbamoylputrescine hydrolase) converts N-carbamoylputrescine to putrescine, a step in polyamine biosynthesis in plants and bacteria. This subgroup includes Arabidopsis thaliana CPA, also known as nitrilase-like 1 (NLP1), and Pseudomonas aeruginosa AguB. This subgroup belongs to a larger nitrilase superfamily comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13), this subgroup corresponds to class 11. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer; P. aeruginosa AugB is a homohexamer, Arabidopsis thaliana NLP1 is a homooctomer.	7.34524e-172
CP022040.2|ASE17521.1|1282573_1283761_+|dicarboxylate/amino-acid:cation-symporter	gnl|CDD|366058	pfam00375, SDF, Sodium:dicarboxylate symporter family.	1.45475e-73
CP022040.2|ASE17516.1|1275942_1276221_-|hypothetical-protein	gnl|CDD|377375	pfam04505, CD225, Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.	9.04683e-23
CP022040.2|ASE17527.1|1293280_1294102_+|hypothetical-protein	gnl|CDD|224495	COG1579, COG1579, Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only].	2.60232e-21
CP022040.2|ASE17528.1|1294511_1295027_-|diguanylate-cyclase	gnl|CDD|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	4.46706e-40
CP022040.2|ASE17529.1|1295039_1296221_-|putative-C-S-lyase	gnl|CDD|275146	TIGR04350, aminotransferase_class_I_and_II, putative C-S lyase. Members of this subfamily are probable C-S lyases from a family of pyridoxal phosphate-dependent enzymes that tend to be (mis)annotated as probable aminotransferases. One member is PatB of Bacillus subtilis, a proven C-S-lyase. Another is the virulence factor cystalysin from Treponema denticola, whose hemolysin activity may stem from H2S production. Members of the seed alignment occur next to examples of the enzyme 5-histidylcysteine sulfoxide synthase, from ovothiol A biosynthesis, and would be expected to perform a C-S cleavage of 5-histidylcysteine sulfoxide to leave 1-methyl-4-mercaptohistidine (ovothiol A).	7.98929e-164
CP022040.2|ASE17514.1|1274303_1275050_+|peptidylprolyl-isomerase	gnl|CDD|365914	pfam00160, Pro_isomerase, Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyze peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilized in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function.	7.38672e-41
CP022040.2|ASE17513.1|1273406_1274216_+|molecular-chaperone-DjlA	gnl|CDD|236512	PRK09430, djlA, co-chaperone DjlA.	3.87307e-25
CP022040.2|ASE17515.1|1275155_1275497_-|TM2-domain-containing-protein	gnl|CDD|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	1.39818e-15
CP022040.2|ASE17530.1|1296217_1297393_-|PLP-dependent-transferase	gnl|CDD|223699	COG0626, MetC, Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism].	4.50441e-117
CP022040.2|ASE17517.1|1277172_1278240_+|agmatine-deiminase-family-protein	gnl|CDD|377332	pfam04371, PAD_porph, Porphyromonas-type peptidyl-arginine deiminase. Peptidyl-arginine deiminase (PAD) enzymes catalyze the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia. PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (pfam03068), which is a metalloenzyme. PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologs). The predicted catalytic residues in PPAD are Asp130, Asp187, His236, Asp238 and Cys351. These are absolutely conserved with the exception of Asp187 which is absent in two family members. PPAD is also able to catalyze the deimination of free L-arginine, but has primarily peptidyl-arginine specificity. It may have a FMN cofactor.	4.36664e-164
CP022040.2|ASE17526.1|1292303_1293119_+|Nif3-like-dinuclear-metal-center-hexameric-protein	gnl|CDD|376614	pfam01784, NIF3, NIF3 (NGG1p interacting factor 3). This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.	8.36983e-87
CP022040.2|ASE17937.1|1275557_1275926_-|DUF2752-domain-containing-protein	gnl|CDD|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	1.08995e-12
CP022040.2|ASE17520.1|1280838_1281876_-|aspartate--ammonia-ligase	gnl|CDD|235456	PRK05425, PRK05425, asparagine synthetase AsnA; Provisional.	0
CP022040.2|ASE17523.1|1285526_1287797_+|sodium:proton-antiporter	gnl|CDD|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	2.23756e-57
CP022040.2|ASE17524.1|1288239_1290954_-|DUF2726-domain-containing-protein	gnl|CDD|350195	cd18808, SF1_C_Upf1, C-terminal helicase domain of Upf1-like family helicases. The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.	8.12364e-38
CP022040.2|ASE17512.1|1272818_1273268_+|hypothetical-protein	gnl|CDD|372640	pfam13588, HSDR_N_2, Type I restriction enzyme R protein N-terminus (HSDR_N). This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA.	4.58584e-51
CP022040.2|ASE17522.1|1284085_1285309_+|peptidase-T	gnl|CDD|235484	PRK05469, PRK05469, tripeptide aminopeptidase PepT.	0

Protein sequences

>CP022040.2|ASE17520.1|1280838_1281876_-|aspartate--ammonia-ligase
MSQLIKPEGYKAVLGKRQTEQGIKLIKEFFQQNLATELRLSRVTAPLFVLKGLGINDDLNGVERPVSFPIKDLGEAEAEVVHSLAKWKRLTLADYDIQPGYGVYTDMNAIRADEELDNLHSLYVDQWDWEAVITEGDRTRSFLENVVRRIYAAILRTEFLTCETYPQLEPFLPQTIHFIHAQDLLDMYPTMTAKEREDEVCKKYGAVFIEGIGCRLSNGEKHDGRAADYDDWSTVAEDGKTGLNGDILIWYPILDRSIELSSMGVRVDKTALLRQLTIEKQEERQQLFFHQQLLSDKLPLCIGGGIGQSRLCMIMLHKAHIGEIQASIWPEEMRRECEEAGMPLI
>CP022040.2|ASE17519.1|1279753_1280140_+|hypothetical-protein
MRMKMLILIGFITVSCTSVPNKKCIVQKNQVRVIKTEKSTAFKYLQGIWIIPHAADIRIVFKNDSTFEFHDYNSIKDSIEILKGIYVLNNDQLTLRYTDRPQQKFIYHFGRYEDERYIRKGKYYFVKQ
>CP022040.2|ASE17518.1|1278327_1279212_+|acyltransferase
MRELKIGFLQQHNVEDIKNNIERLAEGITNLAQRGAELVILQELHNSLYFCQTEDVNKFDLAETIPGPSTGFYGELARELGIVIVTSLFEKRAPGLYHNTAVVIEKDGSIAGKYRKMHIPDDPAYYEKFYFTPGDLGFHPIDTSVGRLGVLVCWDQWYPEAARLMALQGADMLIYPTAIGYESSDTDEEKQRQREAWTTVMRGHAVANGLPVIAVNRVGHEPDPSEQTQGIQFWGSSFVAGPQGELLYRACDNDEDSVILSINLDHSENVRRWWPFLRDRRIDEYGEITKRFID
>CP022040.2|ASE17517.1|1277172_1278240_+|agmatine-deiminase-family-protein
MNTNENHSFRLPAEWEPQSGVILIWPHEDTDWRPYLEEITEVYLQMADAITRYEALLITARETEMVSSLLKGRLTEEQMKRVTLFTCDNNDTWARDVAPISLIANKASKDSFHPLRLLDFCFNGWGEKFAAEKDNRINRQLHEAGLLQGVLENHKDFVLEGGSIESDGSHTLFTTTSCLMAPHRNQPLTQEDIDKQLRLFFPNVERVIWLDYGQLAGDDTDGHIDTIVRIAPNDTLLYIGCDDKEDEHYEDFQLLEEQLKQLRTQKGEPYRLLRLPMPDAIYDDDERLPATHANFLIINGAVLVPTYNQPEKDKEALDTIQEAFPDREIIGIDSRTIIRQHGSIHCLTMQLPANG
>CP022040.2|ASE17516.1|1275942_1276221_-|hypothetical-protein
MEEMNTPKPNNNLALAIFTTVCCCLPAGIYAIIRAMKVNELYMMKQYDEAVLAANDAKKWSIIGIVVGLIGSILYFVCFGGLAALSTMAGSH
>CP022040.2|ASE17937.1|1275557_1275926_-|DUF2752-domain-containing-protein
MKCIGWLCLGASLLILYYFYNPVTTLWAPKCLLKVATGLQCPGCGIQRALHALLQGRFSEAIHYNYFLLFSGPYILSFGVRALLPKGKAKDSLTKVIEDKRLIWLYIILFFIWFIVRNILKI
>CP022040.2|ASE17515.1|1275155_1275497_-|TM2-domain-containing-protein
MESEKVNHMLMMLSSKIPAGSIPSVRTRLENTDISESEILALQSQMKDPLLSILLSIFIGTLGVDRFYIGDVGLGIGKLLTGGGCGIWWLIDIFLIVDATKQKNLELLSYYLR
>CP022040.2|ASE17514.1|1274303_1275050_+|peptidylprolyl-isomerase
MATRLKIKTTEGDIIIRLYDETPKHRDNFLKLAKEGYFNGTLFHRVIKDFMIQGGDPDSKNAPKGKMLGTGGPDYTIPAEFVYPQYFHKRGALSAARTGDEVNPEKESSGSQFYIVWGKTFKPAELKQMEHQMAMQQEQQVFNQLTREHHEEIMNLRRNRDRVGLQELQDKLIEQTKTTCKQQGKPSFTEEQIEVYTNVGGTPFLDNQYTVFGEVEEGLGIVERIQNCDTDRNDRPTEDVKIETVALL
>CP022040.2|ASE17513.1|1273406_1274216_+|molecular-chaperone-DjlA
MAIGKWIGGALGWILSGSMLGGLVGYCIGTMLDEAFAGDNRGGDRQNGYGEQSHFGGTRPFEEDRNSFLFSMLVLSSYIIKADGKIMHSEMEYVRQFLRHNFGEQAVSQGESILLKLFDLQKQQGPYQFKETIRKSCVEIHFHTSVSQRLQLLNYLVIIAKADGIVSPEEVVALKEIASYLGLSAQDIESMLNLESGAKASSNIEDAYKVLGISPSATDDEVKAAYRKMALKHHPDRVSTLGDDIRKAAEKKFQEINDAKERIYKARGL
>CP022040.2|ASE17512.1|1272818_1273268_+|hypothetical-protein
MMQLNLPPYQIRVREENGRKQIFDVLRRKYIALTPEEWVRQHFIHYLIEHKSYPVTLLANEVPLQVGEKKVRADSVLYDNQLRPRMIIEYKAPTIPLTQKVFEQISVYNLLLHVDYLIVSNGLDTYICKMDYENQTYAFLETIPDYQNI
>CP022040.2|ASE17521.1|1282573_1283761_+|dicarboxylate/amino-acid:cation-symporter
MQKKIKIGLLPRVIIAILLGLFLGYYLPDPAVRVFLTFNSIFSQFLGFMIPLIIIGLVTPAIAGIGKGAGKLLLATVAIAYVDTIVAGGLSYGTGTWLFPSMIASTGGAIPHIDKATELTPYFTINIPAMVDVMSSLVFSFIAGLGIAYGGLRTMETLFNEFKTVIEKVIEKAIIPLLPLYIFGVFLSMTHNGQARQVLLVFSQIIIVILVLHVLILIYEFCIAGAIVKHNPFRLLWNMLPAYLTALGTSSSAATIPVTLKQTVKNGVSEEVAGFVVPLCATIHLSGSAMKITACALTICMLTDLPHDPGLFIYFILMLAIIMVAAPGVPGGAIMAALAPLSSILGFNEEAQALMIALYIAMDSFGTACNVTGDGAIALAVNKFFGKKKETTVLS
>CP022040.2|ASE17522.1|1284085_1285309_+|peptidase-T
MEIVERFINYTKFDTQSAEDSETVPSTPKQLIFAKYLKEELEREGLKDVEMDEMGYIYATLPANTKKKIPTIGFISHYDTALDASGANVNARIVENYDGGDIQLNPNMVSSPRMFPELLEHKGEDLIVTDGTTLLGADDKAGIAEIVQAMCFLRDHDEIEHGDIRIAFNPDEEIGMGAHHFDVEKFGCEWGYTIDGGDLGELEYENFNAAGAKVFIHGVSVHTGYAKGKMVNASRLACEFNNMIPETEIPEETEGYQGFYHLIGIESRCEEAKLSYIIRDHDREHFEDRKRFMENCVKKMNEKYGEGTVELKMNDQYYNMKEKIDPNMHVIELVLQAMQQANVAPKVQPIRGGTDGAQLSFKGLPCPNIFAGGVNFHGPYEFVSVQVMEKAMQVIINICRLTAEFND
>CP022040.2|ASE17523.1|1285526_1287797_+|sodium:proton-antiporter
MSELPELVQDLALILVVAGFVTLLFKKLKQPLVLGYIVAGFLVSPHMSYTMSVVDKDDIQTWADIGVIFLLFSLGLDFSIKKILKMGASPIIAACTIIFSMMLLGVIVGHSFGWKEMDCIFLGGMVAMSSTTIIYKAFSDMGLTQQGFASTVMSVLILEDILAIVMMVMLSTVASGNSPDGVQLLGSIMKIGFFLVLWFVVGLFAIPLFLRSVRKILNSETLLIVSLGFCCLMAVISTQVGFSAAFGAFVMGSILAETVEADKIIRLVDPVKNLFGAIFFVSVGMLVKPDVIVQYAIPILLLVITILVGQALFGTLGYLLGGQTLKNAMRCGFSMAQVGEFAFIIATLGKSLGVISEFLYPVVVAVSVITTFLTPYMIRAAEPCYNILIKHLPKRWVRRLTHIQTNSAGESASSDNHWKVLMKKMILNTLIYGILSAAVIAIMFSAALPICRNLSIKWTGSHWIGNAVCGFLTILFIAPFLRSIVMKQNHSEAFKALWTDRRINRLPLTATILARVLIALSFIFYICNYLTRFKNALMIAVAVGLLILMLLSRWLKKRSITLERLFIQNLQSRDIEAQKQGKKKPLFANHLIDRDIHIANLELPDDSLWAGKTLYSLKLRNRFGVHISSILRGSKHINIPNGGTILFPGDKLQAIGNDEQLTKLSKAMKAELQPTITDIEKHEMKLRSFTISKTSPFIGKTLKDSGIRDEYNCMVVGVDEGQKNLTLITPSRSLQAGDVLWVVGEEKDLERILALG
>CP022040.2|ASE17524.1|1288239_1290954_-|DUF2726-domain-containing-protein
MDAKQCMIVDLERRGDKQMFITDQVDFIKKADNGNWMIRFLKSPRIFQYNQARILYFTHGEPVNLHEKGLYIGNKHITSAVELLRFSNKHYTFYYVTYSNGYSENLDGNNVYVTRTPIDMCGGSTWDYLRKLADETGLLAEDEESILSKQYDLIDLKRDNVPLAQYLGDKTKLATYRLPQLVYYPFGCNASQKKAVEAALTHQASIIQGPPGTGKTQTILNIVSNLLVQKKTVLVVSNNNSAVENVAEKLEKEGLGFLVAQLGSVKNKEAFVESQSGCYPNMEEWYLDNSKEVRKIAKDSLAAVSLGFDGQTRLAQLKAEYDALVTEKKYDEKLKMASGFDNDWLSEKHSSKIMKLLNLCKIMQEHGKTPSLLFCFKWVFLLGPRAYSLLKNNLLIVIEQLESAYYLTRKFEIEQEVDSIEQQLLSVDVKESAEELRKSSLQVLKQAIAKQYGSGRRTLFTRQDIKPRTETFLKEYPIVLSTTYSAKSCISKDFVFDYMIMDEASQVDIKTGALALSCAANVVIVGDDMQLPNVVSSEEEKALNAIRTTYNVDDRYNAVTHSFLRSCTEILKDAPTTLLREHYRCHPKIIQFCNQRFYGGELLPMTIDKGEEDVLQVIQTVKGNHAREHFNQREIDVIVQEVMPLCAGKGSVGIITPYRTQAEAINRVLGKDIASTVHKYQGRECDTIIMSMVDNLPTSFSDDKNLLNVAISRAKSQLYIVTSGNEMAQDTNLAQLISYVKYNNFAVKNSKIHSVFDLLYQQYTTERLAYQSEHIMVSDYMSENLVYNLIVKVLEELSWKNLAVVCHYPLAKIISDWSLLSNQENDFAKNSLTHIDFLIYNSLTKQPLMAIEVDGWLYHKDKVVQQSRDRLKDQILTKYSLIPYRISTTDTITAESLKEVFVSL
>CP022040.2|ASE17525.1|1291296_1292217_+|hypothetical-protein
MIIQMKRNKLTALIALIGIVAFTSCEDVKRPTPVRERINVTPPSREAEAISQLTASIDEISANLDAISSQEAMLCKTTEHANKKSKIIQQIRGLGALLKEKQNQIDKLLNEKVKKVDAPAVSNPTIDNLYKVIDFLSSQLKEKGDRVTQLEQVASRKDVTVDQLKYIVMNQTNSVDAMRYRFNMAALEREYAQLKAKEKQRIKEDKESDKVYYIIANKETLKEKGLLKTSLFSKKVNNNNVTKDLFTEANGKDLKTLTINSSSPKLLSQNPEGSYTLTENEDGTTTLTITDAEKFWNVSRYLIIQE
>CP022040.2|ASE17526.1|1292303_1293119_+|Nif3-like-dinuclear-metal-center-hexameric-protein
MRSVKIKEVIDALERFAPLPLQESYDNAGLQVGLTEAEVSGALLCLDVTEKVVDEAIRRECNLIVAHHPLIFRKLAQVTDANYVQRTVIKAIKNDIVIAAMHTNLDSAVGGVNYKIAEKLGLKDLRFFGRSKQVVNPQTGESVTGGDGVIGEFEEPLAADDLILLLKKKFDAECVQTNELLRREIRTIALCGGSGAFLLQDAIAAGADAFMTGEMSYHEFFGHEQEIQICVIGHYQSEQFTIEVLRDVIERECPSVKCYLSEINTNPIGYF
>CP022040.2|ASE17527.1|1293280_1294102_+|hypothetical-protein
MAKKDPKELPVEEKLKALFQLQTTLSGIDEKRALRGELPLEVRDLEDELEGLHIRIEKIEQDIKDYQNAITQKKGNIVDAQASLERYNKQLDSVANNREYDTLTKEIEFQTLEIELCNKKIKEAQIKVEEKRKDLEANRALLEDRQHALEEKRNELDEIMQETREEEGLLKEKAAELETKIEPGLLRSFKRIRRGARNGLGIVYVQRDACGGCFNKIPPQRQLDVKMHKKIIVCEYCGRILIDPELAGVKVDKTEEKPKKRRATRKKKEEEGE
>CP022040.2|ASE17528.1|1294511_1295027_-|diguanylate-cyclase
MEALEALLTRRSVRAYEERMPEQDLIAKVMEAGLYAASGKNMQTAIIVEVTNKEVRDRLSAINAEIMGVTSDPFYGAPVVLAVLADKSSPNHVYDGALMMGNLMNAAHALGLGSCWINRAKQTFEREDGKQMLKEWGIKGDYEGVGFCILGYAAKEGKTAPRKANRIFYVK
>CP022040.2|ASE17529.1|1295039_1296221_-|putative-C-S-lyase
MMKTYNFDEIIDRSGSGDLKHEALLPRWGRNDLLPLWVADMDFACPDFVVEALKDRLSHPIFGYTVEPEDFRPAIIDWIRAHHDWEVKPEWLSFIPGIVRGIGFVVNVFTELDEKVIIQPPVYHPFRLTPEANHRKVVFNPLRLREDGYYDMDFDNLAEVCDDKCRVLILSNPHNPAGLCWSEDTLRRLADFCYEHNIIVISDEIHSDMALFGNRHIPFASVSERAAQISITFAAPTKTFNMAGIVSSFAIVPNEELRNRFYGWLKANELDEPTLFAPIATIAAYRKGEEWRKQMLAYVEENVRFVEDFCREYIPGIRPLRPQASFLVWLDCHGLGLKHKELLNLFIDKAHLALNDGRMFGPGGEGFMRLNVGTPRSILRQALEQLAEAVNEL
>CP022040.2|ASE17530.1|1296217_1297393_-|PLP-dependent-transferase
MKKQTQAIHQPYKRRDAYDALSMPIYNAVAFEFDNAKVMADAFCGRIDAPDYSRVENPTVTNLEQRVKALTGAENVIALNSGMAAISNTLFSVVEQGKNVITSRHLFGNTYSLLTSTLSRLGVEARLCDLTDVEAVERLIDDNTCCLFLEIMTNPQLEVVDVRALTSIAHQHGIPVIADTTLIPFTQFSAKDLGIDLEVVSSTKYISGGATSLGGLVIDYGTFPSIGKRLLNEMLFNLGAYMTPQVAYMQTLGLETLDVRYRAQAGNALELAQRLRTLKPIHKVNYVGLEDNPYHQLAVSQYGETAGAMVTIDLESQEACFRMLDNLKLIHRATNLFDNRTLAIHPASTIFGLFTAEERAAMDVQDTTIRLSIGLESVDDLFDDIKQALEA

Crispr_ID: CP022040_3

• CRISPR_ID: CP022040_3
• CRISPR_location: 1513606-1513702
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022040_3

Consensus_repeat	Method
TGCAAAGATAGTGCAAATGAGAACAAAAGA	CRISPRCasFinder

spacers of CP022040_3

>3.1|1513636|37|CP022040|CRISPRCasFinder
AAGCTTACATTCACTTTGTTGAGTGCAGCCTATCTTA

CRISPR arrays and Neighbor proteins around CP022040_3

CRISPR arrays

The CRISPR arrays of CP022040_3

>merge|CP022040|3|1513606-1513702|CRISPRCasFinder
TGCAAAGATAGTGCAAATGAGAACAAAAGAAAGCTTACATTCACTTTGTTGAGTGCAGCCTATCTTATGCAAAGATAGTGCAAATGAAAACAAAAGA

>CP022040|3|3|1513606-1513702|CRISPRCasFinder
TGCAAAGATAGTGCAAATGAGAACAAAAGA	AAGCTTACATTCACTTTGTTGAGTGCAGCCTATCTTA
TGCAAAGATAGTGCAAATGAAAACAAAAGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022040.2|ASE17689.1|1520541_1522365_+|lipoyl-synthase	unknown	unknown	gnl|CDD|235493
CP022040.2|ASE17691.1|1524231_1526124_-|DNA-mismatch-repair-endonuclease-MutL	unknown	unknown	gnl|CDD|234630
CP022040.2|ASE17676.1|1505154_1506546_+|asparagine--tRNA-ligase	unknown	unknown	gnl|CDD|235176
CP022040.2|ASE17679.1|1508866_1509358_+|hypothetical-protein	unknown	unknown	unknown
CP022040.2|ASE17675.1|1503469_1505014_+|pseudouridine-synthase	unknown	unknown	gnl|CDD|224108
CP022040.2|ASE17685.1|1515526_1517644_-|cation:proton-antiporter	unknown	unknown	gnl|CDD|223551
CP022040.2|ASE17687.1|1519599_1519884_-|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|224278
CP022040.2|ASE17686.1|1518382_1519396_+|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|237845
CP022040.2|ASE17692.1|1526132_1526423_-|ubiquitin-carboxyl-hydrolase	unknown	unknown	unknown
CP022040.2|ASE17680.1|1510591_1511620_-|nitroreductase	unknown	unknown	gnl|CDD|184853
CP022040.2|ASE17681.1|1511616_1512210_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
CP022040.2|ASE17677.1|1506657_1507317_+|hypothetical-protein	unknown	unknown	gnl|CDD|368573
CP022040.2|ASE17682.1|1512693_1513578_-|tRNA-threonylcarbamoyladenosine-dehydratase	unknown	unknown	gnl|CDD|224100
CP022040.2|ASE17947.1|1509630_1510056_+|hypothetical-protein	unknown	unknown	unknown
CP022040.2|ASE17683.1|1513777_1514638_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225543
CP022040.2|ASE17678.2|1507639_1508824_+|hypothetical-protein	unknown	unknown	unknown
CP022040.2|ASE17688.1|1519912_1520320_-|FMN-binding-domain-containing-protein	unknown	unknown	gnl|CDD|377242
CP022040.2|ASE17674.1|1501983_1503330_+|adenylosuccinate-lyase	unknown	unknown	gnl|CDD|236452
CP022040.2|ASE17690.1|1522539_1523703_-|OmpA-family-protein	unknown	unknown	gnl|CDD|143586
CP022040.2|ASE17684.1|1514734_1515442_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022040.2|ASE17689.1|1520541_1522365_+|lipoyl-synthase	gnl|CDD|235493	PRK05481, PRK05481, lipoyl synthase; Provisional.	7.33884e-165
CP022040.2|ASE17691.1|1524231_1526124_-|DNA-mismatch-repair-endonuclease-MutL	gnl|CDD|234630	PRK00095, mutL, DNA mismatch repair endonuclease MutL.	4.4944e-180
CP022040.2|ASE17676.1|1505154_1506546_+|asparagine--tRNA-ligase	gnl|CDD|235176	PRK03932, asnC, asparaginyl-tRNA synthetase; Validated.	0
CP022040.2|ASE17675.1|1503469_1505014_+|pseudouridine-synthase	gnl|CDD|224108	COG1187, RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis].	2.05711e-83
CP022040.2|ASE17685.1|1515526_1517644_-|cation:proton-antiporter	gnl|CDD|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	1.41468e-57
CP022040.2|ASE17687.1|1519599_1519884_-|antibiotic-biosynthesis-monooxygenase	gnl|CDD|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	1.01451e-19
CP022040.2|ASE17686.1|1518382_1519396_+|aspartate-semialdehyde-dehydrogenase	gnl|CDD|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
CP022040.2|ASE17680.1|1510591_1511620_-|nitroreductase	gnl|CDD|184853	PRK14851, PRK14851, hypothetical protein; Provisional.	6.09331e-16
CP022040.2|ASE17681.1|1511616_1512210_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.58224e-10
CP022040.2|ASE17677.1|1506657_1507317_+|hypothetical-protein	gnl|CDD|368573	pfam05708, Peptidase_C92, Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family. Amidase_YiiX is a family of permuted papain-like amidases. It has amidase specificity for the amide bond between a lipid and an amino acid (or peptide). From the structure, a tetramer, each monomer is made up of a layered alpha-beta fold with a central, 6-stranded, antiparallel beta-sheet that is protected by helices on either side. The catalytic Cys154 in UniProtKB:Q74NK7, Structure 3kw0, is located on the N-terminus of helix alphaF. The two additional helices located above Cys154 contribute to the formation of the active site, where the lysine ligand is bound.	2.2926e-13
CP022040.2|ASE17682.1|1512693_1513578_-|tRNA-threonylcarbamoyladenosine-dehydratase	gnl|CDD|224100	COG1179, COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism].	2.38552e-93
CP022040.2|ASE17683.1|1513777_1514638_-|GntR-family-transcriptional-regulator	gnl|CDD|225543	COG2996, COG2996, Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only].	2.18112e-73
CP022040.2|ASE17690.1|1522539_1523703_-|OmpA-family-protein	gnl|CDD|143586	cd07185, OmpA_C-like, Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA. OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.	7.84239e-20
CP022040.2|ASE17688.1|1519912_1520320_-|FMN-binding-domain-containing-protein	gnl|CDD|377242	pfam04205, FMN_bind, FMN-binding domain. This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins.	1.54955e-09
CP022040.2|ASE17674.1|1501983_1503330_+|adenylosuccinate-lyase	gnl|CDD|236452	PRK09285, PRK09285, adenylosuccinate lyase; Provisional.	0
CP022040.2|ASE17684.1|1514734_1515442_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	5.74643e-117

Protein sequences

>CP022040.2|ASE17682.1|1512693_1513578_-|tRNA-threonylcarbamoyladenosine-dehydratase
MQNQFSRTQLLLGKPAIDTLNGSRVAVFGVGGVGGYAVEVLARSGVGAIDVIDDDRVCLTNVNRQLLATTRTVGKHKVDVAEERIHSINPRCIVRKYQTFYLPDNADQFDFSHYDYVIDCIDTVTAKLDLIYRCHEMNIPLLSCMGAAYKLDATQFRVTDIFKTINDPLAKVIRKKLRKTKIKHLKVVYSPEEPLESIEQPEISCRFHCICPDKDMRKCTDRHTIPSSNAWVPAAAGLIAGGEAVKDLVNLANTMRIRPEDEATSEPARIAHERAAKMLEEHKRLKAEKAAADK
>CP022040.2|ASE17681.1|1511616_1512210_-|TetR/AcrR-family-transcriptional-regulator
MKNREQTESRILEAVASIVESEGFEKLGINTIASKANVSKMLIYRYFGGLEELIAQFIMQKDYWANTGTVIINPQSVGDSIKNMFRKQIEQLRNDVTLRRLCRWELSCNNTSIEQLRDKREENGCSLIKLVSTLTGCSNTEVASLASILSAAISYLALIEDQCLSYNGISLQTDKGWNEIMKGVGMIVDLWIKSIQE
>CP022040.2|ASE17680.1|1510591_1511620_-|nitroreductase
MRKVIIVFVIFMGFMDNIMAQNPDYLFMIENACKAPSGHNTQPWLFKIRESEIDIYPDLSKELPVVDPSHRELFVSLGCATENLCIAAQEKEYQTEVKVIKDSFIRVLLTKDKKKQFESSLFSQIAVRQTNRSVYDGKEIPKDSINLLKATSNDPSISIYFYKRGTVDYEKVANMVYAGNSLQMNNEAFKSELTKWMRYNKKYQNNTRDGLSYATFGAPNVPLFLAKFIMSKAINAKTQNKGDRKKIASASHFVLFTTKDNTVEQWVALGRTLERILLRSTQMGIANAYLNQPNEENDITKEMVKQLQISNEYPTILIRLGYGKKMPYSLRRDYRSCILPAD
>CP022040.2|ASE17947.1|1509630_1510056_+|hypothetical-protein
MQIQGTGLSKEFKPYELCCDLGYNITDNLYADLRYENAIALFKENGVKDYAHSHIVGLNLGYIVYHTENCNIGAQIGYGSNMKRKNSDWKYDYYEAMAFTDLGTCKIKPRFGLGIRHYNSRTNLYKDRTVVFVSIGFGINW
>CP022040.2|ASE17679.1|1508866_1509358_+|hypothetical-protein
MLSIPDEYRKDKQLQCSHCGEIFNNYMIKKKKQQSKVDKFLITFAIFLTLWGVKACIDSQPRSSKNSVDNQYESSISIGDNVEVIKTTIGLIDEASVDEFGNAAVAGDATGVDQLIITGKGRQIPAGEQGKVIKRTVSADRIRLNDGTAWWIPISADLKKINE
>CP022040.2|ASE17678.2|1507639_1508824_+|hypothetical-protein
MIQNVFDELTKQLRKNIEAQDYYKSIVTEIRIGYNANANVIQLMHPSQVLDLRTEDLIFPDREWDIDKEFEEAIAIYFTFSMKADKKELQLFQELDIRKYFKEIKDFGIRAYAIDCGKDYNKAATYVNIILEKVYNVSEGSTITIETSDFNNIESAKICKESLTVPYKITGIATRVKEQKEDTLSNETPLPEISDKTYNRLLFGAISIIILILIVFIVNMTQKETPTTDDIRAATQDTTLYVDSASTAPFGVVSSNSETSISTQETASEPEQNQVIGKWIETSYGNNGATWLLEKEASTGRLLLTSRLGDIIQSYNCTKRRIKGNNSYIFHDPNVSGNNGLFSMRKGTTIYYISGFDNNSDAILVPTQDGSAKIYSNDIDNRYYELFSDLSSVN
>CP022040.2|ASE17677.1|1506657_1507317_+|hypothetical-protein
MKLNKILSNLILLLLILLVSCSTDSFQDEDISLRNLHEGDLMFVVKETSNPITDATQGINGLKIDHVAIFHHTDSADYALEAYGKAVSLTPLTNFLNRTKGKEGKPLIAVGRVIVDCDMNTSMKRALSYLGRPYDRFYMPDDKEIYCSELIQKSFVDHHGLPIFSTIPMSFHDNNGKILDAWTQFYAFYHHEVPEGEPGTNPGQLSRDKAVKVNYKLEK
>CP022040.2|ASE17676.1|1505154_1506546_+|asparagine--tRNA-ligase
MKRTKIVDALACTDFGKDINVKGWVRSHRSSKAVDFIALNDGSTIKNIQVVVDPSTIDEDKLKSITTGACISVIGTLVESQGAGQTSEIQCKEIEIYGLCPSDYPMQKKGQSFEYMRKYGHMRLRTNTFGAVFRIRHNMAIAIHQYFHEHGFYYFHTPLITGSDAEGAGNMFQVTTLDLDRVAKGGEVDYSADFFGKRTNLTVSGQLEGELGATALGAIYTFGPTFRAENSNTPRHLAEFWMVEPEVAFIDKDELMDLEEDFIKYCVRWALENCKDDLEFLNKMIDKELIARLEGVLKEDFARLTYTEGFEILQKAAADGVKFEFPITHWGMDLSSEHERYLVEEHFKRPVIMTDYPSEIKSFYMKKNEDGKTMQGTDVLFPRIGEIIGGSVREESYEKLVEEIESRGMKRDIYDWYLDTRKYGTCPHGGFGLGFERLILFVTGMQNIRDVIPFARTPKNAEF
>CP022040.2|ASE17675.1|1503469_1505014_+|pseudouridine-synthase
MAEEFENKEVQSEQNENSRDGYSAAEQGGYQREYRGTGRTQRPRIHSQRAYSSDKANSSNDEGGFRPEGFGSGLQSAGRPQQGGYRPRQNSYGGGYNNNRGGYQSRPQQGGYRPRYNSNGEEGGYQPRQQGGYNRGGYQSRPQQGGYRPRYNNDENGYQPQAYRPRYNANNGAEGEENNNYQANQGGYQPRQGGYQPRQQGGYQSRGGYNNNRGGYNNNRGGYQSRGGYNNNRGGYNNRGGYNQGGYRQHSTDYDPNAKYSLKKRIEYKEENYDPNEPIRLNKYLANAGVCSRREADEFILSGAVTVNGEVVKELGSKVMRTDEVYFQDKLVSLEKKVYVLLNKPKDYVTTSDDPQQRKTVMDLVKGACPERIYPVGRLDRNTTGVLLLTNDGDLASKLTHPKFLKKKVYHVFLDKAITANDLQKISDGIELEDGEIKADAIEYADPQDQTQVGIEIHSGKNRIVRRIFESLGYRVVKLDRVQFAGLTKKNVRRGDWRFLTEKEVDMLRMGAFE
>CP022040.2|ASE17674.1|1501983_1503330_+|adenylosuccinate-lyase
MTLDALTAVSPIDGRYRSKTESLADYFSEYALIRYRVRVEIEYFITLCELPLPQLESFNSALFEQLRDIYRNFDEASAARVKEIESITNHDVKAVEYFIKEEFDKIGGLDDYKEFIHFGLTSQDINNTSVPLSVKEALEEVFYPQVEELIAQLKEYAEAWEDVPMLAKTHGQPASPTRLGKEVEVYVYRLSEQLATLRNCKMTAKFGGATGNFNAHHVAYPQHDWRAFGNRFVSEKLGLEREQWTTQISNYDHLGSVFDAIRRINTIIIDLDRDFWMYISMEYFKQKIKAGEVGSSAMPHKVNPIDFENSEGNLGVANAILQFLAQKLPVSRLQRDLTDSTVLRNVGVPVGHSVIAIQSTLKGLRKLILNEEKLREDLENTWAVVAEAIQTILRREAYPHPYEALKALTRTNEKMTEETIHAFVQTLNVSDSVKAELMAITPYNYTGI
>CP022040.2|ASE17683.1|1513777_1514638_-|GntR-family-transcriptional-regulator
MSKIKLGAYNTLTVLKIALREGNGDPFGIYLDGGPAGEILMPQKYVPEGTEIGDELEVFVYLDQDERPIATTEEPLAQVGDFAYLECSWVNEYGAFLSWGVMKDLFCPFREQKKRMTIGNSYIVYIHLDEESYRLVASAKVEHYLDEQPRGYKHGQEVDLLIWQKTDLGFKVIVDNKYPGLIYEDQVFQYVHTGDRLKGYISTVRRDGKIDCTLQPTGQQHAEGFAEVLLQYLKDNDGVCDLGDKSEAEDIKRRFQVSKKVYKRAVGDLYKRHLITVDPLSIRLVK
>CP022040.2|ASE17684.1|1514734_1515442_-|ABC-transporter-ATP-binding-protein
MIDIKNITKSFGSLQVLKGIDLRIEKGEVVSIVGPSGAGKTTLLQILGTLDKPDSGSVVVDGIDVGSLSAGKLSDFRNQHLGFVFQFHQLLPEFTALENIMIPAYIAGKKNKDARQRAEELLEFMGLSDRANHKPNELSGGEKQRVAVARALVNNPAVILADEPSGSLDSKNKQELHQLFFDLRDKFGQTFVIVTHDEGLAQITDRTIHLKDGLIESLPQPLRKEGSATIKIENE
>CP022040.2|ASE17685.1|1515526_1517644_-|cation:proton-antiporter
MLNLSQYFPITDPTLIFFVVLLMILLSPIIMGRLRIPHIIGMVLAGVLVGKYGLNILGRDASFELFGRVGLYYIMFLAGLEMDMEGLKKNRNRVMIFGMLTFLIPFAMTYFMGVSLLGYIPLASLLLAAIMASNTLIAYPIVGRYGLTRHTSSTLSVGSSMMALFMALIVMASIVNSFHGNGGILFWLLFILKFVAYCVGLIMVIPRVTRWFLRRYSDAVMQFIFILAVVFLSAALSDAVGLEGIFGAFMSGLILNRFVPKVSPLMNRIEFTGNALFIPYFLIGVGMLINVRLLFAGSKILWVVFCIVFFGTLGKAVAAYVAARIFRMSWLAGHMMFGLTSAHAAGAIAMVMVGRRLEVAPGQYLFGDEVLNGIVIMILFTCVISTVITERAAQRLRLQEKEDQNMMKNLDDEKILIPVKYPEYSDNLITMATLMRNPRLKRELVALNVVYDDVNMRHNQAEGQRLLDHLCHLASASDVPMVTQVRVAANIANGIKHAFKEFQASEILMGLHFHKEINRSFWGEFTRSLYNGLSRQIIVTRILQPLNTIRRIQVAIPSRAEFEPGFYRWLERLARMAGNLECRIAFHGRNETLQLVNEFIRNRFPSVRAEYEEMAHWKELPTLGSQVREDHLFVIVTARKGTISYKTAMERLPEELNKFIKGKTIMIIFPDQYGSEMDDMTFAQPQHTEERSAYEAVREWIHNKV
>CP022040.2|ASE17686.1|1518382_1519396_+|aspartate-semialdehyde-dehydrogenase
MKVAIVGASGAVGQEFLRILAERNFPMDDLVLFGSERSAGKKYTFKGKEYEVKLLQHNDDFKDVDIAFTSAGGGTSAEFAETITKYGAVMIDNSSQFRQDNDVPLVVPEINAEDALNRPRGIIANPNCTTIMMVVVLNPIDKLSHIKKIHVSSYQSASGAGAAAMAELQQQYKELVETGEVKTIEKFPHQLAYNVIPQIDKMTENDYTKEEVKMFNETRKIMHSDVRTSATCVRVSSLRSHSEAVWFETERPLSVEEIREALKAAPGVTVVDDPQNYVYPMPLESAGHDDIYVGRIRKDLADDNGNTLWLTGDQIRKGAALNAVQIAEYLIKVGDVK
>CP022040.2|ASE17687.1|1519599_1519884_-|antibiotic-biosynthesis-monooxygenase
MIRLNAFFKVKAGVTTAQVKALTDELVELSRKDEGNKGYDLFESTTQPGVFLFCETWADKACLTRHARSEHFTRIVPELEKLTDGGLSIEQFER
>CP022040.2|ASE17688.1|1519912_1520320_-|FMN-binding-domain-containing-protein
MLKKQFVSVAAVAVLTTGVAFAAVQQDKVMYKQADGTYVVNTTSLCSNVKGFKGATPVEVYIKNNKVIKVEALPNREGPKFYDKVKQGLFPKFNGMKLSKAAKAESLDGVTGATYTSRAVKENIAAAVAYYKKNK
>CP022040.2|ASE17689.1|1520541_1522365_+|lipoyl-synthase
MKYILLPKPDTIHQLPFYFAVEEYVARHYTDDDYFMGWRVNPTVMLGRNQLIDNEVNTDYCKEHKIDIFRRKSGGGCIYADKGCIQFSYISCAVNANEAFADYMQRMADLLKGLKIDAQLSGRNDILINGTKVSGCAFYQLSNRSVLHNSLLFDTQLDHLSNALTPAKEKLQSKGVASVRQRVTNVATYIQLDILAFMDYVRQEMCGTEVLELTEEDMKGVAEIEKELSSDDFVYGKNPKYSLVRKHRFEGVGTLEAHIELKNNIIGSINMVGDYFLLGDIDHDFLSLLKGCEFTREAVEERLENIDLSTIIRGLKLRQFLRLLFGREPHVMKPKWLKIDLTSKKSTGETAGILAKHHMNTICTSGLCPNRSECWMARTATLMIGGDICTRKCRFCNTLSGRPRLLNPDEPRRVAESVKALKLRYAVITSVDRDDLPDYGAAHWIKTIEEIRRLNPDTKIELLIPDFMGKADLIRQVMATHPHVAGHNMETVRRLTPSVRSVARYERSLEVLREIANCGITAKTGFMLGLGETHDEILETMDDILSTGCQRLTLGQYLQPTAEHLPVKAYITPEMFAEYKRIALEKGFKHVVSGPLVRSSYHAAEGV
>CP022040.2|ASE17690.1|1522539_1523703_-|OmpA-family-protein
MKKLLIVLALAGVSMTGFAQDEVLTEKYSVATNSFWSNWFVQLGADWNAWYSNQEHGRDAAISPLKDFRSKPGAAFAIGKWFTPGIGLRTKIQGIWGKRVGADSNPASQLDNSNKYWIAQEQVMFNLSNLLCGYNENRVWNLIPFAGAGVGRSMSANRYAMGLSAGLQSSWRVSKGMRVYLEAGWNRYESDLDGAAYANNERRGWESHDNNLYAEIGLNFNIGKGTWKKSPDMEAINTQHQAALDALNARLQDAEEENTRLRNELANQKPVETVSESVKQLVTTPVSVFFEINQSTIASQKDLVNVQALAKYAKDNNNNLLVTGYADSATGSADYNQKLSERRATVVANELVKMGIENNKITTVGKGGVETLSPISFNRRATVQITE
>CP022040.2|ASE17691.1|1524231_1526124_-|DNA-mismatch-repair-endonuclease-MutL
MSDIIQLLPDSVANQIAAGEVIQRPASVIKELVENAIDAGATHIDVLVVDAGRTSIQVIDDGKGMSETDARLSFERHATSKIRKADDLFSLRTMGFRGEALASIAAVAQIELKTRMESEDLGTHLSIAGSRFTGQEPCSCPVGSNFLVENLFFNVPARRKFLKSNTTELNNIITAFERIVLVYPQISFTLHSNGTELFNLRACSYRQRIVEVFGKRLNQDLLPIDVDTSLCHIHGFVGKPESARKKAPHQYFFVNDRYMKHPYFHKAVITAFDRLIPQGEQVPYFLYFDVPAENIDVNIHPTKTEIKFENEQAIWQILLAAVKEAVGRFNDIPAIDFDTEGKPDIPVFNPNVGMSAPKVDFNPAYNPFKQTSQPAKSSVPDGWEELYADLGSGGEIRQSKLFKQREDEMISSSLGTVSDTVEEGTIIPSAATQSAAESLIEDKAPSHYQYKGCYIMTAVKSGLMIIDQHRAHIRILYEEYLHQLSEHKVHSQKVLFPEMVQFSVSDQVVLDQILPEMAEMGFQLDSLGGGSYAVNGVPAGIEGLNVVALINDMVASAMESGTSAKEEIDQALALSLARNAAIPQGQVLSSMEMDNIVNELFACSNVNYTPSGEPVIAIMKQQDIEHLFDS
>CP022040.2|ASE17692.1|1526132_1526423_-|ubiquitin-carboxyl-hydrolase
MLFFQSSRPRRFHHEYMYVDERKELLNDIEQRARRELNGEEVPEGKYREELQRKISGSLKPEVLRHRGNRFTAMWVSLILSAGVIALLTLFLFFAL

Crispr_ID: CP022040_4

• CRISPR_ID: CP022040_4
• CRISPR_location: 1623736-1623868
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP022040_4

Consensus_repeat	Method
ATAAAGACACCCACAACGCATTTGTCTTAACTCCATTTCACTCCTT	CRISPRCasFinder

spacers of CP022040_4

>4.1|1623782|41|CP022040|CRISPRCasFinder
CAACTCCTTTAACTCCCAAATAGGAACAATGGAAAATCAAC

CRISPR arrays and Neighbor proteins around CP022040_4

CRISPR arrays

The CRISPR arrays of CP022040_4

>merge|CP022040|4|1623736-1623868|CRISPRCasFinder
ATAAAGACACCCACAACGCATTTGTCTTAACTCCATTTCACTCCTTCAACTCCTTTAACTCCCAAATAGGAACAATGGAAAATCAACATAAAGACACCCACAACACATTTGTCTTAACTCCATTTCACTCCTT

>CP022040|4|4|1623736-1623868|CRISPRCasFinder
ATAAAGACACCCACAACGCATTTGTCTTAACTCCATTTCACTCCTT	CAACTCCTTTAACTCCCAAATAGGAACAATGGAAAATCAAC
ATAAAGACACCCACAACACATTTGTCTTAACTCCATTTCACTCCTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP022040.2|ASE17763.1|1628834_1629323_-|hypothetical-protein	unknown	unknown	unknown
CP022040.2|ASE17767.1|1634128_1634749_-|DUF2238-domain-containing-protein	unknown	unknown	gnl|CDD|378345
CP022040.2|ASE17768.1|1638630_1641915_+|SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|380297
CP022040.2|ASE17760.1|1622239_1623577_+|HD-domain-containing-protein	unknown	unknown	gnl|CDD|234897
CP022040.2|ASE17757.1|1616885_1618910_-|peptidase-M23	unknown	unknown	gnl|CDD|227278
CP022040.2|ASE17953.1|1635249_1638627_+|helicase	unknown	unknown	gnl|CDD|197275
CP022040.2|ASE17758.1|1618910_1619822_-|DUF4292-domain-containing-protein	unknown	unknown	gnl|CDD|372917
CP022040.2|ASE17769.1|1641930_1642584_+|DUF4145-domain-containing-protein	unknown	unknown	gnl|CDD|372658
CP022040.2|ASE17756.1|1614356_1616165_-|long-chain-fatty-acid--CoA-ligase	unknown	unknown	gnl|CDD|223953
CP022040.2|ASE17754.1|1612167_1612665_-|CYTH-domain-containing-protein	unknown	unknown	gnl|CDD|143629
CP022040.2|ASE17762.1|1625203_1628650_+|DNA-helicase	unknown	unknown	gnl|CDD|273041
CP022040.2|ASE17764.1|1629955_1631776_+|arginine--tRNA-ligase	unknown	unknown	gnl|CDD|223097
CP022040.2|ASE17753.1|1611815_1612208_+|antibiotic-resistance-protein-VanZ	unknown	unknown	unknown
CP022040.2|ASE17952.1|1621576_1622014_-|dUTP-diphosphatase	unknown	unknown	gnl|CDD|234802
CP022040.2|ASE17752.1|1610381_1611743_-|sodium-dependent-transporter	unknown	unknown	gnl|CDD|271367
CP022040.2|ASE17759.1|1619818_1621555_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|274350
CP022040.2|ASE17765.1|1632006_1632474_+|ribonuclease-H	unknown	unknown	gnl|CDD|260015
CP022040.2|ASE17766.1|1632809_1633667_-|enoyl-ACP-reductase	unknown	unknown	gnl|CDD|187630
CP022040.2|ASE17761.1|1623940_1624936_+|esterase	unknown	unknown	gnl|CDD|283403
CP022040.2|ASE17755.1|1613069_1614185_-|peptide-chain-release-factor-2	unknown	unknown	gnl|CDD|234799

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP022040.2|ASE17765.1|1632006_1632474_+|ribonuclease-H	gnl|CDD|260015	cd13935, RNase_H_bacteria_like, RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. This family includes bacterial ribonuclease H (RNase H) enzymes. RNases are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication, repair and transcription. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H inhibitors have been explored as an anti-HIV drug target because RNase H inactivation inhibits reverse transcription.	3.07378e-65
CP022040.2|ASE17767.1|1634128_1634749_-|DUF2238-domain-containing-protein	gnl|CDD|378345	pfam09997, DUF2238, Predicted membrane protein (DUF2238). This domain, found in various hypothetical bacterial proteins, has no known function.	3.91098e-38
CP022040.2|ASE17768.1|1638630_1641915_+|SAM-dependent-methyltransferase	gnl|CDD|380297	NF033455, BREX_6_MTaseX, BREX-6 system adenine-specific DNA-methyltransferase PglX.	1.7674e-10
CP022040.2|ASE17760.1|1622239_1623577_+|HD-domain-containing-protein	gnl|CDD|234897	PRK01096, PRK01096, deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional.	2.9875e-137
CP022040.2|ASE17757.1|1616885_1618910_-|peptidase-M23	gnl|CDD|227278	COG4942, COG4942, Membrane-bound metallopeptidase [Cell division and chromosome partitioning].	1.05911e-20
CP022040.2|ASE17953.1|1635249_1638627_+|helicase	gnl|CDD|197275	cd09178, PLDc_N_Snf2_like, N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family. N-terminal putative catalytic domain of uncharacterized archaeal and prokaryotic HKD family nucleases fused to putative helicases from the Snf2-like family, which belong to the DNA/RNA helicase superfamily II (SF2). Although Snf2-like family enzymes do not possess helicase activity, they contain a helicase-like region, where seven helicase-related sequence motifs are found, similar to those in DEAD/DEAH box helicases, which represent the biggest family within the SF2 superfamily. In addition to the helicase-like region, members of this family also contain an N-terminal putative catalytic domain with one copy of the conserved HKD motif (H-x-K-x(4)-D, where x represents any amino acid residue), and have been classified as members of the phospholipase D (PLD, EC 3.1.4.4) superfamily.	1.14749e-31
CP022040.2|ASE17758.1|1618910_1619822_-|DUF4292-domain-containing-protein	gnl|CDD|372917	pfam14125, DUF4292, Domain of unknown function (DUF4292). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 243 and 287 amino acids in length.	2.93386e-32
CP022040.2|ASE17769.1|1641930_1642584_+|DUF4145-domain-containing-protein	gnl|CDD|372658	pfam13643, DUF4145, Domain of unknown function (DUF4145). This domain is found in a variety of restriction endonuclease enzymes. The exact function of this domain is uncertain.	2.114e-13
CP022040.2|ASE17756.1|1614356_1616165_-|long-chain-fatty-acid--CoA-ligase	gnl|CDD|223953	COG1022, FAA1, Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism].	5.72556e-172
CP022040.2|ASE17754.1|1612167_1612665_-|CYTH-domain-containing-protein	gnl|CDD|143629	cd07891, CYTH-like_CthTTM-like_1, CYTH-like Clostridium thermocellum TTM-like subgroup 1. This subgroup contains the triphosphate tunnel metalloenzyme (TTM) from Clostridium thermocellum (CthTTM) and similar proteins. These are found primarily in bacteria. CthTTM is a metal dependent tripolyphosphatase, nucleoside triphosphatase, and nucleoside tetraphosphatase. It hydrolyzes the beta-gamma phosphoanhydride linkage of triphosphate-containing substrates including tripolyphosphate, nucleoside triphosphates and nucleoside tetraphosphates. These substrates are hydrolyzed, releasing Pi. Mg++ or Mn++ are required for the enzyme's activity. CthTTM appears to have no adenylate cyclase activity. This subgroup consists chiefly of bacterial sequences. These enzymes are members of the CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) superfamily, which have a unique active site located within an eight-stranded beta barrel.	3.09628e-79
CP022040.2|ASE17762.1|1625203_1628650_+|DNA-helicase	gnl|CDD|273041	TIGR00376, DNA-binding_protein_SMUBP-2, DNA helicase, putative. The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair].	8.26776e-39
CP022040.2|ASE17764.1|1629955_1631776_+|arginine--tRNA-ligase	gnl|CDD|223097	COG0018, ArgS, Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis].	1.08343e-141
CP022040.2|ASE17952.1|1621576_1622014_-|dUTP-diphosphatase	gnl|CDD|234802	PRK00601, dut, dUTP diphosphatase.	7.67455e-93
CP022040.2|ASE17752.1|1610381_1611743_-|sodium-dependent-transporter	gnl|CDD|271367	cd10336, SLC6sbd_Tyt1-Like, solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain. SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.	0
CP022040.2|ASE17759.1|1619818_1621555_-|tetratricopeptide-repeat-protein	gnl|CDD|274350	TIGR02917, TPR_domain_protein, putative PEP-CTERM system TPR-repeat lipoprotein. This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.	4.82063e-26
CP022040.2|ASE17766.1|1632809_1633667_-|enoyl-ACP-reductase	gnl|CDD|187630	cd05372, ENR_SDR, Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR. This bacterial subgroup of ENRs includes Escherichia coli ENR. ENR catalyzes the NAD(P)H-dependent reduction of enoyl-ACP in the last step of fatty acid biosynthesis. De novo fatty acid biosynthesis is catalyzed by the fatty acid synthetase complex, through the serial addition of 2-carbon subunits. In bacteria and plants,ENR catalyzes one of six synthetic steps in this process. Oilseed rape ENR, and also apparently the NADH-specific form of Escherichia coli ENR, is tetrameric. Although similar to the classical SDRs, this group does not have the canonical catalytic tetrad, nor does it have the typical Gly-rich NAD-binding pattern. Such so-called divergent SDRs have a GXXXXXSXA NAD-binding motif and a YXXMXXXK (or YXXXMXXXK) active site motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.75466e-99
CP022040.2|ASE17761.1|1623940_1624936_+|esterase	gnl|CDD|283403	pfam05728, UPF0227, Uncharacterized protein family (UPF0227). Despite being classed as uncharacterized proteins, the members of this family are almost certainly enzymes that are distantly related to the pfam00561.	2.53385e-12
CP022040.2|ASE17755.1|1613069_1614185_-|peptide-chain-release-factor-2	gnl|CDD|234799	PRK00578, prfB, peptide chain release factor 2; Validated.	3.30728e-151

Protein sequences

>CP022040.2|ASE17760.1|1622239_1623577_+|HD-domain-containing-protein
MNWQQLISNKRLGQEERHALRHDDRSEFKRDSDRLIYSAPFRRLQNKTQVFPLPGSVFVHNRLTHSLEVASLGKSLGDDVARRLIEIHPELRGTLFEEIGTIVQTACYAHDMGNPPFGHSGEKAMQAFFTEGPGISLKEKVSPHFWEDITHFEGNANAFRLLTHRFLGRREGGFVMTYSTLASIVKYPFSSTYASKHGKFGFFATEEETYKKIADELGIIQKDSSEAGICYVRHPLTYLMEAADDICYEIMDIEDSHKLKLLSFEETADLLLGFFDEETRKSIRKRIEEEGVTDQNEQVVYFRACAVGLLEAECVNVFVEHEEEILNGTFEGSLIKHISELPRQAYKHCTEVSVDRIYRSKAVLDVELSGYKIMETLMKALIGAAVEPEHFHSQQLIRSFSSQYDIQSPCLETRIMAVLDFISGMTDIYALDIYQKINGISLPLI
>CP022040.2|ASE17952.1|1621576_1622014_-|dUTP-diphosphatase
MIQIKVINKGHQQLPAYATSQSAGMDLRANIDAPIVLQPMERRLIPTGLHIALPVGFEAQVRPRSGLALKHGLTVLNSPGTIDADYRGEIMVLLINFSDEPFTINDGERIAQMVIARHEQAEFVEVEELDETERGEGGYGHTGVK
>CP022040.2|ASE17759.1|1619818_1621555_-|tetratricopeptide-repeat-protein
MFNNVILKVTKMRRTLLALALLGGSLAMHADREDSLQSYNYFFLEAIRQQEMGNLTAAFDLLCHARDLNPQAPEVYYQLAAFYVDMKKDAVAREYFEKAASLDPENSAYQEKLGKLYVSQKDYPNAIKAFERLYESNKTRSDVLQILYQLYGSQNDYKMMIKCLERLETLEGTNEQISLSKMQLYEQMGEKRKEYDELKALVDSHPLDLNYRVMFGNWLLQNGKKKEALQKYRDVLKEDPDNSLAKLSMMDYYNNIGDKATVKTILQELLQSPKTEKEAKLELLRQVITSSQKDNTPDSTEVMRLFSVALAVPQEDADIYMLKAAYMTLRKQPKAAVNRVYEQALEVEPDNSRARIALIQNIWDTQDYDKVIAICRPAIEYNPDEMAFYYFQGMAQFQKHDGDAALETFRKGVGQIKPDSDPSIVSDFYAIMGDILHEKGRNKEAFQAYDSCLQWKADNVAALNNYAYYLSEANENLTKAEQMSYKTIKAEPNNSTYLDTYAWILFQQKRYEEAKIYIEQAIRNDSTLSNVVKEHAGDIYAQTGDIEKALEFWRKALEGNKENATLRKKIELKKYIAE
>CP022040.2|ASE17758.1|1618910_1619822_-|DUF4292-domain-containing-protein
MKKTKILLVSMTALLLASCGTKKAVIQQKPVQDNKAAQQTAPATKDSKMQSVVVMQRVADNALYQKNLVSNLTFTLNDGHKDITVPGILRMRKDEVIRLQLLIPILRSEVGRIEFAKDYVLFIDRIHKQYVKASYDEVGFLRDNGINFYSLQSLFWNQVFIPRQQKVSEADLSQFAVDESKAQTEGSTLISLKDGKMDYKWSVNPKSNQIVLTTVTYNSNTHGASKLSWSYDDFKAFGSKLFPASQMLTINTPKFGQKPAKTLKASFDLESFSDISDWEVFTTPSDKYTKVSVEDILGKLMNF
>CP022040.2|ASE17757.1|1616885_1618910_-|peptidase-M23
MKRLSLLFILSIMCMLSVSAQHSRKHRKQQKTAVAQSVEPQTTVKGKGKKAVNAINNNHAVAPATPVKGQKPIVEKLQTQPQPKGKQQQGKLQHQQQLKGQQPQLKGQPAQVKGQQVVRGKGAVRNAHVGKKGAKGPAYVTTEEIKGLQQQNLKLQKEISEHEEEMKVKQKDVDDRLQKIVRLDTEIGQHQRTIDTIATDIKGLDSNIGILKGQLASLEAQLGERRARFIRSMRYMARHRSIQDKLMFVFSAKNLTQMYRRLRFVREYAAYQRAQGEQLKAKQMQVDEKHTQLKQVRVNKSNLLYKDRQVHAQMERKRVEQQTVVSSLQNDQKVLQGVIAQRRQQQQALNAQIDRLIQIEIQKARERAIAEAKAQAAARAAAAKKRAEELARKKAAAEAAARENARRIAEAKEREAKAKAAARAAAEAAEKARQEAAARAAAARAAAEKARQEALQKERAAARERAIRKVEEQEAAAKAAQEKAEARAAAEKARADQMAREAEANRVAAERKADADRERAAREAEAARASAAENNDMLSSADRAITGNFANNRGRLPMPLSGQIVSHFGQYNVAGMSNIRLNNDGINIKGAPGSAVRSVFMGEVSGVFMAGGMSVVMIRHGIYISVYANLGSVGVSKGQKVGTGQTIGTVGKTGILQFQLRKETAKLNPEQWLR
>CP022040.2|ASE17756.1|1614356_1616165_-|long-chain-fatty-acid--CoA-ligase
MQTIGHLSVLIHEQAKKYGAKPAITFRNFGSLDWKTVSWNQFSMRVKEVSNALLNLGMKPQETIAVFSQNCIHHLYTDYGAYGVRVISIPFYATSSEQQIQYMIQDANVKFLFVGEQEQYDKARRIQSLCPTLERIIVFDSSVRLSQHDPNSIYFADFLKLGEGFPREAEVEERLAQANYDDICNILYTSGTTGESKGVILTYKMYQAAMDANRKSVPVNEKDRVINFLPFSHVFERGWACLSLAAGAELIVNTYPKEIQQSMRETHPTSMASVPRFWEKVYVAVKERMDKSSIVQRKLFYHALNVGRKRNIQYLARGKRVPLTLEMEYKFVNKTVLSLVRKQLGLENPHLFPTAGAYVSPEVEEFVHSIGINMIVGYGLTESLATVTCDHVGQPYTVGSVGRPLEGIDIKISDEGEVMLKGPTIMPGYFRRDTTNAEAFDKDGYFHTGDAGYMKDGELFLKERIKDLFKTSNGKYIAPQMVEAMLLVDKFIEQVSVIADQRKFVSALIVPEYSVLEEWARENHIEFKDREELCQDKRVNEMMRERIETLQQRLASYEKIKRFTLLAHHFSMENGELTNTLKLKRSVVNRRYHDVIEKMYEE
>CP022040.2|ASE17755.1|1613069_1614185_-|peptide-chain-release-factor-2
MITADQLKDIQERTEALHRYLDIDKKRIEFEEEQLRTQAPDFWDDPARAQEQMKKVKDIEKWVKDYDKARALADEVQLAFDFYKDELVTEEEVDTAYAKVLKVIEGLELKNMLRQEEDPMECVMKINSGAGGTESQDWASMLMRMYMRWGEAQGYRVTISDIQEGDEAGIKSVTMKFEGGEYAYGYLKSENGVHRLVRVSPFNAQGKRMTSFASVFVTPLVDDTIEVYVDPARVSWDTFRSSGAGGQNVNKVESGVRLRYQYEDPDTGEQEEILIENTETRDQPKNRAKAMQLLKSQLYDRAMKKRMEEQAKIEAGKKKIEWGSQIRSYVFDDRRVKDHRTNYQTSDVDGVMDGKIDDFIKAYLMEFPTEE
>CP022040.2|ASE17754.1|1612167_1612665_-|CYTH-domain-containing-protein
MSGLEIERKFLVHKNMDWKKHASSCSHMQQGYFAAVNTVRVRIRDDKGYLTIKGPSRTGGLSRYEFEKEITLEEAQQLMLLCEPGVIDKHRYLVPFEGHTFEIDEFHGDNDGLVLAEVELGSEDESFDKPDFIGLEVTGNRHFYNSQMRRNPFKLWRDIVPEEYR
>CP022040.2|ASE17753.1|1611815_1612208_+|antibiotic-resistance-protein-VanZ
MSITKHILTKYPFSCIIVIGTWILCFMTIPETPLSSVRFIDKWTHSLIYLVLGLSISLEYLRNTKQPSPKFIIVWVWFLPIIMGGLIEVLQSYCTNGNRSGEWLDFFADAIGSTIAVLIGILLVRYRAKA
>CP022040.2|ASE17752.1|1610381_1611743_-|sodium-dependent-transporter
MSEQKRAKFGSKLGMILATAGGAVGLGNVWRFPYMTGQNGGAAFILIYIGCILLLGLPCMISEFIIGRHAASNTARAYTKLSNGSVWKWVGYLGVLTGFLITGYYAVVSGWCLQYGVASVMNHLHGTPDYFKSYFTDFSTNPWKPVLWTVMILLFTHYVIIHGVRNGIERASKILMPALFVLLVAIVVASCLLPGASKGVEFLLKPDFSKVTGDVFLGALGQSFYSMSIAMGCICTYASYYSRHTKLLNSAVQIGIIDTCVAILAGLMIFPAAFSVGVSPDSGPSLIFITLPNVFEQAFASMPIVGYIISMAFYLLLSMAALTSLISLHEVSTAFFQEELHISRPRAAMIVTAGCSLIGAVCSLSLGDWSFLKVAGVDLFDVFDFVTGQIFLPIGGLLTCLFIGWYVPKKLVKDEFTNWGTTRGIFFGAYYFLIRFVCPLAILAIFLHQLGVF
>CP022040.2|ASE17761.1|1623940_1624936_+|esterase
MENQYKKTFPDLMVGKKIIYVHGFMSAGSSHTVQILRDYMPEATVIAPDLPIHPEEAMELLRNLVNTEKPDLIIGTSMGGMYTEMLYGVDRICVNPAFQMGTTISETNMMGKQVFQNPRQDGVQEVIVTKALVKEYKEITEKCFSQVTEEEQQHVFGLFGDADPVVHTFDLFNEHYPQAIRFHGEHRLIEKAVFHYLMPVIRWIDDRQEGRERRTVLIDQNTLTDGYGKPKSSLNKAYEFLLDNYNVFFVCPAPTNNPSTITEQQAWIEDAFSAPAWNHTIFTNQPQLLYGDYFISSTEHDDFLGTSLLFGSEEFKTWEEIITFFERLGGQ
>CP022040.2|ASE17762.1|1625203_1628650_+|DNA-helicase
MAHELFSRIADILSAPSEAQALIMHETLVIACHEGLKNTRHGFGNLSSQVESLCRQHNIAPQDIVAIQKMRRHSNSNAPILPEDVAYDCRALAIFVSAVVQEAIPSFLVGKIPARGRTTENIQITNYRYIRCIVREWDDSTIQVAVTNQDSSEELLTVDYMNTPDYIDFSYLRPMLRERMQLNLLDCTVTRKKVVPRLIVVEPDYLIDISTIANCFETYGHHPLLFTVNRLTPRLSNKHIVLGNFAGSALDDIINHPAGYDIKETFRSNFKEKALDYATCPDFDAASFKQDAERQVENIKGIVDEIFQTFDREKAILEPSFVCERLGIQGRVDLMTTDLKLLVEQKSGKNTFIERKYKNPHGSLHVEKHYVQVLLYYGILQYNFQLSPKNAHIQLLYSKYPLPDGLLEVEPLQKLIREAIRFRNQAVATEFWMADNGFDRMLPLLTPQTLNVEKQNDNFYNRYLLPQLTETLAPLHQLNDLERAYFTRMMTFVIKEQLVSKVGVQEGVGNSNADLWNMPLAEKKETGNIYTELTIIEKGRSSSFNGYDTITLAVPQQGEDFLPNFRRGDMIYLYSYKKNEAPDVRQSILFKGSLQEIHGDSITVHLNDGQQNPDLISGDYFAIEHAGSDIGGTSAIRSLYTFITSNEERRQLLLGQRVPCVDKSLTLSHSYHPDYDEIILKAKQAQDYFLLIGPPGTGKTSQALQFLVREQLAGNIYSQPSSAYSAEDSKHNKPSETINTQHSTPNTQTAILLLAYTNRAVDEICNMLTENDIDYIRIGNEFSCDPKYSDHLLKEVLDDNATLNSIKSTLADAQIVVATTSTMNSNAALFNIKHFDLAIIDEASQILEPNIIGLLTSQHRGGRAIRKFILIGDHKQLPAVVQQSDTEVLIEDETLKAIHLNSCTNSLFERLILTERAAGRTEFVGTLHKQGRMHPDIADFANRKFYAREQLECVPLAHQLEQTLAYNETSEDETDDVLKAHRMIFIPSKPCRQLNISEKVNTEEARIITDLLRRLYRQLGKNFDPQKSVGVIVPYRNQIAMIRKEIEKLGIPELEEISIDTVERYQGSQRDIILYSFTIQSRYQLDFLTANTFYEDGQPIDRKLNVAITRARKQLILTGNEQTLRHNQLFAELIDYIKEKGGYYAEKA
>CP022040.2|ASE17763.1|1628834_1629323_-|hypothetical-protein
MRKSIQKWTYALVASVFALVMCLSLSACGSDDDNDVNNGISPVLYSDFGGEIGVNYPLGISGKFVGFSIPKSQAGKIVDLTKDGDWVAGGSVVGGLYRYDDHFFQKGSYVYLLRTGANEIELRYKYIWKEGTATRTIEGNYKNVKMTTHQDAIDWAHRQGLH
>CP022040.2|ASE17764.1|1629955_1631776_+|arginine--tRNA-ligase
MKIEEQITVAALAAVKELYGTEVPEKMIQLQKTRSDFEGNLTLVTFPLLKTSRKKPEDTAQDLGEYLKKNCKAVADFNVVKGFLNLVIAQAAWTELLNDINADEKFGEKRVTDESPLVMIEYSSPNTNKPLHLGHVRNNLLGWSLAQIMEANGNKVVKTNIVNDRGIHICKSMLAWQKWGNGITPEQAGKKGDHLIGDFYVLFDKHYKEECKQLQEQYEKEGLTAEEAKEKAEHEAPLIKEAHDMLVKWEANDPEIRALWEKMNNWVYAGFDETYKALGVGFDKIYYESNTYLVGKKKVEEGLAKGLFIRKEDNSVWADLTNEGLDQKLLLRKDGTSVYMTQDIGTAEMRFNDYPIDKMIYVVGNEQNYHFQVLSILLDRLGFKWGKDLVHFSYGMVELPNGKMKSREGTVVDADDLVASMIENAKSLSEDKVNKLEGITEEEKNEIARIVGMGALKYFILKVDARKNMLFNPEESIDFNGNTGPFIQYTYARIRSILRKAEAQNITLPASLNDDAPLNEKEIALIQKLNDFGAAVAQAGIDYSPSGIANYCYELTKEFNQFYHDYSILNADTEAEKITRLMIAKNVAKVIKNGMALLGIEVPERM
>CP022040.2|ASE17765.1|1632006_1632474_+|ribonuclease-H
MKELVNPPTNRNDTVLPLPLEVRCPSWAVDAACSGNPGPMEYQCVDLQTGARVFHFGPVMGTNNIGEFLAIVHALALMEKQGIKDKVIYSDSYNAILWVNKKRCKTTFVRNAETEELHQIIARAEHWLQTHKVTTPIIKWETKQWGEIPADFGRK
>CP022040.2|ASE17766.1|1632809_1633667_-|enoyl-ACP-reductase
MSYNLLKGKRGVIFGALNEMSIAWKVAERAVEEGATITLSNTPIAVRMGTVNALSEKLNCEVIPADATNVEDLENVFKRSMEVLGGKIDFVLHSIGMSPNVRKHRTYDDLDYKMLDTTLDISAVSFHKMIQSAKKLDAINDYGSILALSYVAAQRTFYGYNDMADAKALLESIGRSFGYIYGREKHVRINTISQSPTMTTAGSGVKGMDKLFDFADRMSPLGNASADECADYCIVMFSDLTRKVTMQNLYHDGGFSNVGMSLRAMATYEKGLDEYKDENGNIIYG
>CP022040.2|ASE17767.1|1634128_1634749_-|DUF2238-domain-containing-protein
MIDKTKLMLVLLVMIVTVITCIHPIYPNEQTLQHIGTVLLLIPLTMDVFRKQLPMSAFIGIVGFTLLHVIGARYIYSYVPYKEWAVSLGLVEKGFFHDPRNHYDRLVHFSFGALMFPYFVYLCRKWVKQQSFVAVVMAWMMIQTGSLIYELFEWLLTIVMTAEEADYYNGQQGDMWDAQKDMALALVGSTGMFLVYAVRSLIRRGK
>CP022040.2|ASE17953.1|1635249_1638627_+|helicase
MARIYDNIKTKFTEGLQGIITNVGVKRVDFCVGYFNLRGWNLVVDQMDTLTGNYVYENDKHTFRKCRLLIGMHRPTEELIRQLYTDQPLPDANYVSQCKLEIARDFRRQLQLGFPTKQDEFTLRRLSAQMKEEKVCVKLYLREPLHAKLYLAYRPDDNFNKIQAIMGSSNLTYSGLTKQGELNAEFGDSDSAEKLAYWFDERWEDKFCLDITKELIEIIDNSWAGDKDIPPYYIYLKTAYHLSEEARSGIKEFTIPAEFKNCLFDFQQTAVKIAARHLNNEKRGGAMIGDVVGLGKTITACAIAKMYENTFGSNTLIICPANLQDMWEKYRKQYDMKADIMSMAKPIDVDNARYYKLIIVDESHNLRNSQGVRYRNIKDLIQKQDCKVLLLTATPYNKQYKDLSSQLRLFIDDDTDLGIRPEAYIRSIGGERKFAEKHEDFIRSIKAFERSEFQEDWQELMKLFLIRRTRTFIKENYAKTDSKNGRKYLEFKDGHKSYFPDRIPKAIKFQTTEGDQYSRLYSEEMVSLMESLKLPRYGLIHYLDEKKAETASKYEGNLIDNLSRAGERMMGFCKSTFFKRVDSSGYAFLLTLYRHILRNAVYLYAIDNKLKLPVSDENTFPEDFIEDADINKITADSDDNKEFLSNKSLLTIPKKMKDYMERAETYYNSLIGKNNVQWIDSKYFKRTLKQGLKKDCDQLIAMINLCDDWNPQTDQKLNELEKLLSNTHKDDKIIIFTQYSDTAAYVYKQLQKRGIKNIEKVTGDTKNPTAIVERFSPISNRADITKENELRILIATDVLSEGQNLQDAHIIINYDLPWAIIRLIQRAGRVDRIDQSSEQIYCYSFFPADKVEEIIRLRTRLNERINENAGIVGSDEVFFEGNEQNLRDMYNENSSSLDEDEDDIEVDLGSQAYQIWKNATDANPDLKRIIPAIPNIAYSTKAANNINEDGVITYARTYNDFDVLTWYNSKGDIVSQSQKRILQTMACTIKEPCLPAQDVHLSLVEKAVKSIKNENTNVGGILGSRFSTKRKIYELLNHYYEQPLNLFNTQEKKDILKFAIDQVYNYPLLENSKFILGRMMRTGNTHDDIVDTVIEMYENANLCRVDEDKIKHKDPVIICSMGLKA
>CP022040.2|ASE17768.1|1638630_1641915_+|SAM-dependent-methyltransferase
MKRNIFNQYITASDFKGLFVSEMLWNNPTGATQLPEINIDNTTFHIEQIAERKGFQILHCQVEQIPSSAICKKIDHKIRKNAENYICIFILPETLHHLWIAPVKKVEKRDVVLIEYDSLDKAAFLFEKMESLSFSLDDNLTILDIIEKVQSAFLINSEKITKDFYAGFKKEHSNFAKFITGIDDHIDEKENKNKQWYASVMLNRLMFCYFIQKKEFLDGDVDYLRHKLEWTRNQEGEDRFFNKFYKGFLVNLFHDGLNTPKHNHEFEKIYGRIPYLNGGMFDVHQIEREYANLDIADEAFISLFDFFDKWHWHLDDRMTASGRDINPDVLGYIFEQYINDRAQMGAYYTKEDITEYIGRNTIVPYLMDAVKRKNEKHFRANSELWLYLKESGDKYIFDAMKKGVDQTIPEEIATGLDTTKPNLLERRCHWNERTSEAFALPTEIWRETIERLQRYNNIKEKITKGEITNINDFITYNLNIRQFVTDYLANTQDHLFVKHFYHALQHVTILDPTCGSGAFLFAALNILEPLYEVCINRMQEFNAKNPLLFKQELQEIEHKYRSNIQYFIYKSIILRNLYGVDIMVEATEIAKLRLFLKMVAVVEVDKRNPNLGLDPLPDIDFNIRCGNTLVGYATQEELERDLIEGDMYAREEFKEKVNDEMDKVSRTYEIFKNVQLHQAEDMAAFKKAKGELYQRLNTLNDLLNHKMYGAVESTKGYNAWYQSHQPFHWLAEFYEIINEHGGFDVIIGNPPYVEYNKKVKGVAVSDLYKLVGYKTLSCGNLYAYVLERSKNIMRQEGYISMIVPLSGHSTERMAPLVTNFYEKFGLHLHLNLSADANPQKLFEGVKFRLVIFTATNNGVGKYSTKYTRWLADERKNLFNALVRYNSIEDYTYQNIIPKIASPLFISIARKIKEEKVQYFVGIGNEQCLYHNAPVNWIRSHTFVPYFCSDRDGEGITTQLKSVSFDNTKQVKVGSCILNSSLFFIWWITNSDCYHLNKPEIVNFRYQYDKGIEKAICSVADRLAIDMKKKCIRRIYNYKTTGRVEYDEFYMKLSKPIINEIDKLLASHYGFTEEELDFIINYDIKYRMGDELNEE
>CP022040.2|ASE17769.1|1641930_1642584_+|DUF4145-domain-containing-protein
MNQKYVTPARDKDAFTCPHCHTLSLMKFRWHRHDEDVHFVTQRVGYGEYLNQLFIARCVNCGKKIIWINDDYIYPDIVAEDPNVDMPESVKQLYNEAGTIYNKSPRAACALLRLAIDRLCNELGETDRDINKNIGVLVKKGLPQAVQQALDVVRVVGNKAVHPGVISFDVDDKGTATMLMRLLNIITERMITEPKEIESLYEGLPETVKESVTKRDK

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	1079793 : 1132954	41	Lysinibacillus_phage(18.18%)	integrase,tRNA,protease,transposase	attL 1091372:1091391|attR 1111384:1111403
DBSCAN-SWA_2	1273406 : 1281876	9	Catovirus(16.67%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>CP022040|1079793:1132954|DBSCAN-SWA
CTTGAAAAACAAAACATTAATAGTCATCACTGGCCCAACAGGCGTTGGCAAGACAGAGACCACTCTCCGTATTGCAGAGCATTTTAATGTACCTGTTATCAATGCTGACTCCCGACAAATATTCTCTGAGATTCCTATAGGAACAGCAGCACCAACGGCAGAACAGCAGCAGCGTGTACAACACTATTTTGTTGGTAATCATCATTTGGAAGATTACTATTCAGCAAGCCTATACGAACAAGATGTACTTAATATTATTAACAGTCAGCACACACCTATCTCGTTACTCTCAGGTGGTTCAATGATGTATATTGACGCTGTATGCAATGGTATTGATGATATCCCGACAATTCTTCCTGAAATACGAGAGAAAATGATGAAACGCTTAGAAGCAGAAGGATTAGAACAGATGTGTAATCTGTTACGAGAACTGGACCCTGAGCACTGGAAGATAGTTGACAGGAATAATCCACGTCGTGTTATCCATGCCCTTGAGATATGTATCCAAACTGGAAAAACATATACATCTTTCCGTTCCAATACTATTAAAGATCGTCCTTTTAATATCATCAAGGTTGGATTAAACCGTGATAGAGACGAACTCTATAATAGAATCAATCAGCGAGTATTAGACATGATTGAAGAGGGAATGATAGAAGAAGCACTACAAGTTTATCCTAAGCGAACTCTGAATTCACTCAACACGGTTGGATACAAGGAGATATTTGAATACCTTGATGGCTTAACAACACTTGATGAAGCCATATTTAAAATACAGAGTAATACTCGAAGATACGCTCGCAAACAGCTCACATGGTATAAAAAAGATACCGCTTTTCAATGGTTTAATCCCGATAACATTGAAGAAATCTTAAATTATGTCCATACAATGATATCAAATACAAGTAAATAAGTACTTTTGTATTAAACGTATTATAGCAATATTATAAACATAGGCAAGTAGCTTTAAAACTTGAAGGTTGTCAATCAATGATAAAGAAAATATTTAAATTCATTAGAAGTATATTCCGAGGAATTTTCAATTTCTTCCCATGGTACGCAAAACTGTATAAAGGTCGTGCTTGGTACACGAAGATGGCTGTCGGAACAGTATCTTTCTTTGTAGCTATCTTCCTCTATTTAGGAATGGTAGACATTAACTTCCTTTGGCTCTTTGGAAAGTCACCAGGTTTTATTGATATAAAAACTCCTCCAACCTATGCTGCATCAGAGATTTATAGTGCAGACTCTGTCCTCATTGGTAGATTCTATAAAGAGAATCGTACACCAGTAAAGTATGAGGAGGTAACCCCTGCATTCTGGAATGCACTCATCAGCACAGAGGACGAGCGCTTCTATAGCCATAATGGTATAGACTTTATGGGTATCGGTGGTGCCATCAAGGATGCCGTAACAGGTAGTGGAGGTCGTGGTGCATCAACCATCACACAGCAGTTGGCGAAGAATATGTTCCGTGTTCGTACGCAATATTCTTCAGGTCTATTAGGTCATGTACCAGGCTTGCGAATGCTCATTATGAAAAGTAAGGAATGGATTATTGCTGTGAAGTTAGAGTTAATCTATTCAAAGAAAGAAATTCTGACAATGTATGCCAACACCGTTGACTTTGGCAACAATTCCTTTGGTGTAAAGACAGCTGCTAAGACTTATTTTAATACAAGTCCTTCAAAGTTATCTATTGATCAAGCTGCAACGTTGGTAGGTATGTTGAAAGCTACTACTTATTATAATCCAATCTTGCACCCAAAGAATTCTATTCGTCGTCGTAACACTGTGCTGTATAATATGGTTACACATAATGTATTACCACATGATGAGTACGCACTATACTCTAAGCGACCTATGAAGTTGGATATACACGTAGAAGAAAACTATGATGGTCAAGCTCAGTACTTCCGTGAATATATATCAGAATACTTCAAAGATTGGATGAAAGACAATGGTTACGACCTCTATAGCAGTGGTTTAAAGATCTATACCACCATTGACACTCGTATGCAGAAGTATGCTGAGCAAGCTGCAACAAAGCAGATGGAAAAGGTTCAACAAACTTTTGATAACCACTGGAGAGGTATGCAGCCTTGGCGCGATGCAAAGGGAAATGAGATTCCTGGCTTTATTGAGGGCATTGCTGAACGTCAGCCTTTCTATAAGAAGCTATTACAGAAATACCCTAACCAGCCTGATAGCGTTCTCTATTATCTCAATAAACCACATAAGGTGACTCTCTTCGACTATGAAAAGGGGCATATTGAGAAAGAAATGTCATCAATGGACTCTATCCGTTATATGGTTAAATTCATGCACTGTGCTATGGTTGCTATGGAACCAGAGACAGGTGCGGTAAGAGCTTGGGTGGGTGACATTGATTTCAAAACATGGAAATATGATAAGGTTGTTGCACAGCGTCAACCAGGTTCAACCTTCAAACTATTCGTCTACTCAGAGGCATTCAATCAAGGACTGACCCCTTGTGATAAACGTCGTGATGAATATATCAGTATGCAGGTTCTTGATAAGAAGACTGGTCAGATGAAGACTTGGACACCACACAATGCCAATGGTAGATTCTCTAATGATTCTATTACACTGAAGAGTGCTTTTGCTCGCAGTATAAATTCCATTGCTGTACGCTTAGGACAGGAGATGGGTATCAAGAATATTATCCGTACAGCTCAGGAGATGGGTATTAAGAGTCCGTTGGATGATGAGCCTTCATTGGCACTCGGTTCAAGCGACGTAAACTTATTAGAATTGGTAAATGCCTATAGTACTGTAGCAAATGATGGTGAATATCATGTTCCAGTTGTCGTTACACGCATCTTAGATAAAGATGGAAACGAGGTATATGTAGCACCAAAAGACCACGAGAGAGCATTACCTTACAAGACTGCATTCCTCATGCAGGAAATGTTGAAGGCTGGTGTGAACGAAGGTGGTGGTACAAGTCAAGCATTACGTCATTATACTTTTGGTGATACAGACTGGGGAGGAAAGACTGGTACAAGTAATAACCACTCTGATGCTTGGTTTATGGCAGTCAGCCCTAAACTTGTCGTTGGTGCATGGGTTGGTGGTGAATATCGCTCCATCCACTTCCGTACAGGAGCCTTAGGACAGGGTTCAAAGACTGCACTACCTATCTGTGGAGAGTTTATTTACAGCTTAATGCGCGACAAGGCTTTCCAAAAGTATCATGCTAAGTGGCAGTTAGATCCAGACGAGGACATCGACCCTTCAATGTACAACTGTCAACCTACAGTAGTTCGGCGTGCTGCTCCTGATTCTTTGCGTGACTTTACAACAGGACATAGACGTCATCAGGAGGAAGAGGAAGAACCTATCGACGGACACGAAAACACAGACGAGGGTGGCTTTATATTAGAACCAGCTCCACAACCTACTCCAGAACGGCAGGGCAATAGTTCTAATAATGAATCGCCTCAAATTATAAAGAAGGCGAAGAAGCCACGCAGTGAAGATATGGAAATCTAAGTAATTCATAATTCTTAAAATGGAACTTATAATTACTTTTGGTTGATAAAGAAATCAGAATACTTTGGTAATTGATTAATAACTATCAATTCTCTTCCTCAAACAACAAACTTCTATATATTCACAGAGACTTTTACCTCTGTGAGTATATATGAAGGTTTTTGTTTTATCTATAGCCTCTTGTCAGTAAACTTAACAATAGGTCGTTGTAATTATACAGAAAAGGCACAAGGCATAAATATAGCTTAGTAGCAAACATAACTATCAACTGCAAAGGGTAACTAAAGCCCCCCAATCAATGTCACAAAAGAAGGTAAACATAGACGTAAATACGATTGACTTGGATAATACAGAGTTGCAAAAAGCACTTCAGATTATTCAGTTTACAAACAATTCCCTATTCCTCACTGGAAAAGCAGGAACAGGAAAGTCTACATTTCTACGTTACATTGCTGCGACAACAAAGAAAAAACATATTATTCTTGCACCCACAGGCATAGCTGCTATCAATGCAGGTGGTAGTACTCTGCATAGCTTCTTCAAACTTCCATTCTATCCTCTTGTCCCAACTGACAAACGTTATTCTGCTCGTAATCTACGCAGCACAATGAAATACAATGGTGACAAGTGTAAACTTTTGCGGGAAGTCGAACTAATCATTATTGATGAGATTAGTATGGTTAGAGCTGACATCATTGACTTCATCGACAAAGTACTGCGCATATACAATCGTAATATGCGCGAGCCATTCGGCGGAAAACAACTTCTCTTGGTAGGCGACATTTATCAGTTAGAACCTGTTCTAAAGGAAGAGGATCGTCGACTCTTACAACCCTATTACCCAAGTAGCTACTTCTTTGATGCAAAGGTGTTCCAAGATTATCCACTTGTGAGTATTGAACTCAATAAAGTCTACCGTCAAAACGACCCTCACTTTATTTCCATTCTTGACCATATCCGTACGAATCAGGTCACTGACACTGATTTCAACCATATCAATGAACGTGTTGGTGCAAGTTTGGAAAATACAAACAAGCCAGAAGGAGATTTCACCATTACCCTATCGACTAAACGAGATACAGTAGACTGGATAAACAATGAAGGACTTGATAGCCTTGATGGAGATCCTGTTATGTTCTTAGGTGAAATCAAAGGAGAGTTTCCTGAGAGTAGCCTCCCTACTCCTATTGAGTTAAACCTCAAGGTGGGAGCACATATCATGTTTATCAAAAATGACATTGAGAAGCAATGGGTTAACGGAACCTTAGGTATTATTATCGGTATTGATGAGGAAGCAGGAATCCTCTATGTTCATACAGAAGAGGGAGATGACTTACAGGTGCAACGTGAGATGTGGGAGAATATAAGGTACCGATTCAATGAGGAAGAACAACGAATTGAAGAGGAACAAATAGGTACTTATATACAATTCCCCATCAAGTTGGCTTGGGCTATCACTGTACATAAGAGTCAAGGACTGACATTCAAGAATGTAAATATTGATTTCACAGGCGGTGTCTTTGCCGGTGGTCAGGCATATGTTGCTCTATCACGCTGTACAAGTCTTGAAGGTATTACACTCAAGGAACCACTACGTAGAAATGAGGTCTTTGTAAGAAGTGAGGTAACACATTTTGCCAGACACTACAACGATAATAATATTATATCGACAGTACTCAAACAGAGCAAGGCTGATAAAGAATACTACGATGCTGTATGTGCTTTCGACAAGGGAGACTTTGATGCTTTCCTGCGTAGCTTTTTTCTTGCTATTCATAGCCGTTATGATATTGAACGACCAGCAGCTAAGCGATTTATCAGACGAAAACTGGACCTCATTAACCAGCTACGTAATGAAAATGAGGAACTTAAGCGACAACAAGATAAGAAGAATGAGTATCTCAAAGAGCTGTCAGTAGAATATGTTATGATGGGTAAAGAGTGCGAGCGTGAAGAAATGAATGAGGCAGCTATTGCCAATTATGAGAAGGCTATTGCACTCTATCCTGATAATCCAACAGCACAGAAAAGATTGAAGAAATTAAAACCTTCAACCGAAAAAGATAATAAATAATGGAACAGAAAAAGAGTCTTTCAAAAATTATAGCAACAATCGTTTTTGGTATTGTTTTCATCATTATTGCTATTGTATCTTGTAATCAAAGCAAAACAATAGAAGGCAGTAACAATGGAGATACTGTTGCTGCAAAGGAGTTTACACCACATGTTGAGAATGGTAAACTAAATATTGATTTACAGAGTATTACCTCTATTCGCTTTCCTAAATATAAGACAACAAAAGCAATACCTTTTATACCCGACTCTGTTAGTTTAGCGGCTGATGAAGAATCGGTAGAAAGTGGCAACTATTCAGCAACACTACTTCTTGATACGATTCCAAATAAAGAGTTTTATCAGAGAATAGATCTTGCAGCACAGCATGATACGTGTTGGGATATTAACAAATTTGCTTATACTTACGAAAGAAAAGATAAAGCTGGAGGTGTGTATAAAGTCGTATTTAGTAAAGGTGGACAGCAGATATTTGTCACTCATCTGAATAAAGACATGATAAAAAATACGAATCAAACGAAGCCGAACAAATAAACATCACAATACACCCTAATTATGCTTAGGTTCTAAATGAACCAGTTTAGGTTTAATAAAACGCATAAAAAAAGTGTCAAAGCAAGTAGCTTCGACACTTTTTTTATATCCTTTTTAAGTCTTAACGAGCCTGCTCAAGCTTGCTATCAATATGTGCAATAGCATGGCTTTCCAAGTGAGCGAATGAATCGAGAATATCCTTAACATTCTTCTCTTCCTCTACTTGCTCATCAATATACTTTGCAATGAAGTTCTGTGATGCGCGGTCCTTCTCCTCATCAGCAACATCTGCCAACTTGTTGATAAGTTCTGTAACCTTCTGCTCATGCGCAAATGTATCAACAAAGGCCTCCTTAGCGTCTGTCCAACTTGTCTTAACGGCATCGATACTGGTAAGGATAACCTCACCACCACGATGAAGAACAAACTGAGCCATATCCATTGCGTGCTGTCTCTCCTCTTCAGCCTGCTTGTACATCCAACTTGAGAAGCCCTTCCAGCCTTCCTTACGGAACCAGCATGACATCTGTAAATAGAGATTTGATGACCACATTTCTGCCGCAATCTGCGCATTGAACGCATCCTGCATCTTCTTTGATATATTCATTTCTTGTTCTTTTTAATTAGTAATTAATTACTTACTTCGTTAGTCACTAATAATAATTCCGACTGCAAAATTACAACATTATTGTTATTTTTCCAAATTATCAGCCCAAAAATATGATTTTTTCACATGCTTATTAAACTCATATCACACATCTATTTTATCATCCCAGCTATATTTATACTCTTTTTTAGGTGATATGTTATTGCCCCGCACATGTCGTACTGATGATAAACACCAATGGTGCTGAGCACTAATTAAGTTGCTATATATTGCTATGAAAAAGTGTATTTTTATATTATTGGGATGAGGTCTACACCCAAACGGGAATACAAACGTATTTCATCTTACTTTTATATATCAAAAAAGATTTGCATCAAAGCGGTTACTAAAAGTAAACCTGAACTTTGATACAAATCTTTGTTTTCTATACTTATCTTTATAAGTGCATTCTCGTTCTACAAAAGATTATTCAATTACTACAGTTGTCCAACCATGCTTGTCTTCTATCGTGCCATACTGAATACTACGGAGAGTTTCATAAAGCTTGGTAGACCATGGTCCTGGTTTGTCACCAAAATTATAAACTTTACCCGTCTCCATATCATCAAGATGTGATATCGGAGAGATAACTGCTGCTGTACCACAAGCACCAGCTTCTTCAAAGCTATCCAATTCATCTTCTGAAATAGGACGACGCTCTACCTTCATTCCAAGGTCTTCAGCAATCTGCATCAGACTCTTGTTCGTTATAGATGGCAAGATAGAACTTGACTTAGGAGTAACATAAGTATCATCCTTGATACCAAAGAAGTTGGCTGCACCACACTCGTCAACATACTTCTTCTCCTTTGCATCCAAATAGAACTCTGAGGCATAACCTTGCTCATGTGCACGACGATTTGCTCTAAGTGATGCAGCATAGTTACCACCAACCTTATACATACCAGTTCCCAATGGAGCAGCACGGTCAACATCACGAACAATAACATAAGGATTAGCACAGAAGCCACCCTTAAAGTAAGGACCAACAGGAGTAACAAAGATTAAGAAGCAATATTCCTCTGCTGGACGAACACCCACCTGAGCAGATGTACCAATTAACAACGGACGAATATAGAGTGAAGCACCACTCTCGTAAGGTGGGATATATTCTTGATTAAGACGAACAACTTTTTTAACCATTTCTGCAAACAACTCTGTTGGTACTTCTGGCATTACAATACCACGACTTGTATTCTGCAAACGTTTTGCATTTTCTTCTACACGAAAAACACGCACTTTACCATCTGGACAACGATATGCCTTCAATCCCTCAAAAGCCTCTTGACCATAGTGAAGACAAGTTGCTGCCATGTGAAGTTTAAGATACTCATCTGAACTGACTTCTACCTCACCCCACTTTCCATTGCGATAGTAACAGCGAACATTATAATCAGTTGGCATATAGCCAAATGATAAACTTGACCATTCTATATCCTTCATATTATTTTCGTGTTAAGTTATTATTCATGACAATTATCTACAAAAGTAAACAAAATATTCTTACCATGCAACCAAATAACAAGTTAATTAAACTTACATTTCGTTTTCTAAATAAGAAAAAAGAGAATTATTGCTTTTCTAAAAGCTTTTGAATCTCGTTGTCGGTACGCTTAAGCTTTTGTTTACAGAGCTTTACTAACTCTTGAGCTTCTTTTAATTGGGCGGCCATAGAGTCTATATCAAGTTCTCCACGTTCCATTTTATCTACAATAGCTTCCAATTTATGAACTGCTTCTTCGTATTTTATTTCTTTCATTGCCTTTTTACATTTATAATATATGGAATAATATGCTCTTTTAGGATAAACGTTCCACCTTACTCTCTACCTCGCCAGTCTCAAAACGTGTTGTTATCGTATCACCTATCTTTAAGTCTTTAGCGTTACGAATTGTCCTACCATTACACAATGTAATACTGTACCCACGCTTTAAGAGTAAAGAAGGATCAAGTAACCTTGCTCGCTGCTCAAGTATATCGAGTCGATGCTGCTCAACAGACAACTTATTTTGCAGTGTCAGTAACATACAATTTTGTAACGTGCTTAAATAAAATTCTGCCTGTTTTATAGCTTCATTCATTCTCATCACCAGCCGTTGGGATAAGCCTTCAAGCCAAGCATCCTGCTTTGTACGAACCACAGAGAACAATACTGGAATATGTGAACCAATATGTTGAATACGCATTTTCTCAACCTCTAAGGCCTTCTTCACACCATCGATTATCGCAGCTTGCGCGTTTTCTACTCTCATCAACGTTGAAGCAATATGGTCTATGAGATAAGCAGCAGCGGCAGTTGGCGTTTTCATACGTTGAAACGATACCATATCCAAGATGCTTTCATCACGTTCGTGCCCAATACCTGTTATAATTGGTAATGGAAAGTTTGCCACATTCTCAGCAAGATTCAAGGTATCAAAACCGCTAAGGTCGGCTGTTGCGCCACCACCACGAATGATAACAACACAATCGAAATCTTCTTCACGACTATTGATTTGATTCAATGCGTTTATTATACTCTGTTCAACAGAGTCGCCCTGCATAATAGCAGGAAACAATTCTACGTGGAAATAGAGTCCATAATCATTAGTTTCTAACTGATTACAGAAGTCACCATAACCAGCAGCGGTCTCAGAAGAGATAACAGCTATACGCTGAGCAAACATCGGAAGACAAAGTTCTTTTTGCAAATCAAAGACTCCTTCTGCCTTTAATTGACGGATAATCTCTTGCCGCTTACGCATCATATCACCCATCGTATACTCAGGATTGATATCATCAACTATCCAAGAGAAGCCATACTGAGGATGAAATTGAGCATGAACTTGTAACATTACTTTCATTCCAGCTCGTATTTCCTGACCTGTAATACGAATAAAAGCTGGCTTAATAAGTGTCCAAATGTTGCTCCAACACTTTGCTGAAGCACGTGCTATAGGTACATTGCTCCCTTCGTTCTTCTCAATCAGCTCCATATAACAGTGTCCACGATTCTCACGGGCCTCAGACAATTCTGCTTCCACCCAATAAGAACGTGACAGGGTTGCGTCTATCACATCTGCGACAAGACTGTTTAATTCAAATAACGAAAGTGCTTTGGTCATCTTTTAGAAATATATGTTTCACTAACCATTACTGATTATAACGAGTTGCTGACTGATAGGCTGACCAAAAGTCAGGTATACCATATCCCATTATATTGTCAGGAGATTGACAATTATTTCCCGATTGACGAATAATATCTATTATCTCTTTTGCTGATTTATTAGGGCATGCCTGCCACAAACAGGCTACCATACCAGCTATGAGTGGACAAGCGAACGATGTTCCATTGTCTGGTATGATATATCCCCTACCCGATACGACATTTGTTGGACATCCATAAGCCATTACATCTGGCTTAATACGCCCATCAGCTGTAGGACCTATCGATGAAAAAGGAGCATTAACTTTATCAAGAGAAACTGCTCCCACGGTAAGAATATCATGAGCATCAGCAGGAACATTAATCTTCTTCCAAGTTCCCATACCATCGTTACCTGCACTATTTACAAGTATCATTCCCTTACTTGCCAAACGTGATGCTGCTTGAGAAATTGCTGCAGTTCGTCCATTTAAATCTGCGTAACGATAGTTCATAGATATGTCATCAAAGCCGTGATAGCCCAAAGATGAACTAATGATATCAACACCTACAGAATCAGAAAACTCAACTGCAGCTATCCAAAAATCTTCTTCTGCAGGACTTTCTGTCGAATAGTCTTCCGTACGAAGCAACCAGAAATCAGCTTTAGGAGCAGTACCCACAAACACCGTAGGCTGGTTCATCGCTATTGTTGACAAAGTCTTAGTACCATGATCCATCTCTTTATAGACATCATTATCGTACCCTGCAACAAAGTTATGTGTACCTTTTATATTGAGATTCCTAAAGGCAGCAATCTTATCCACATTCATAAAGCCTGCATCCAACACTGCGATAGTCATACCTTGTCCCATAAAACCAAGGTTGTGCAGCTTTCTACCATTCAAACTCTCAATTTGCCCCTTACCCATACCATAATAGTCGTGAACCGTAGAATCAAGAGATTGAAGTTCAGAATTATAACGAACACGTTGAGAAAGTGGACGGATAGAGTCTGGAGAGACAAATACCAGCTTACTATCTTTCACAAAAGACAATACTTTTAAGTCTTCTAACGTTTGGCGATTATTGCCACGCACAAGAACAGAGTTATTCCATTTACTCACAGCAACAACCTTACCACCTCTCTTCTTTATCTGTTGAATATAATCTGGTGATACCGGTAGGTCTGTCGAATCAAGCTTTAATCCCTGACGTTCACGTCGAAGAAGAGAAGCTTTTGATAGAAATTTCTCTGGTTTATCCAAGGAATAAGGTGTTCCATTCTTATCTTTTAAAGTAACACGGAACATATAACACTTTCCTCCTGGGTAACTTATCAAGCCACCACTCTTATTAGAAGCTAATAAAGTAGCGCTGACCAGTATAAATAGGAATATAATATAATTTCTGAGATAAGTTTGTTTCATAATCTGCAAACTTACACAAAATAATTGAATTATACCGCAGATATAAAAAGAAATTAGATAAATAAAAAAGGATTTCCTTTATTAGGAAATCCTTCTTGTACACCCTTAGGGATTCGAACCCTAGACCCACTGATTAAGAGTCAGTTGCTCTACCAACTGAGCTAAGGGTGCATGCTAAACGAAAAGACTTGGGTTAGAAATCAATTCTTGTACACCCTTAGGGATTCGAACCCTAGACCCACTGATTAAGAGTCAGTTGCTCTACCAACTGAGCTAAGGGTGCTCATTTCGTTTTTGCGAGTGCAAAGGTATTACTTTTTTGCGAATTAACCAAACTTTTCTATCTTTTTTTAGTCATAAATCAGTCGATAATATTATGCCATCAGGCTGAAAGTTTAGTATAACTACGTGATAATATGAGTATTACAAAATGACATGGTTCTAAAAGGAAACAATTATTTTTATGTATTTATAATTATCTTTCGCTCCAGATAAGTAAATTCAGACGCCTTTGATGCCTAATCAACTTATATAATTTAACCCAATTCGATCATTAGAGCCTAAACATATTTTGTTTTATTATCGAGCAGATTGTTTGGCTTTGGAACGCAGGCGTAGCGGGCTACGTCAAGTTAAAAAGACGGACAAGATGCCGATAAGAAAATAAAAGATGTTAGGAAACAACACAAAAACAAGAATTCCTGAAACATTGTGGTCTAATGACCGCATTTGGGTTAAACAAAATGAGGATGAAACCTACAACAGTTTCATCCTCATAATATCGTTTTATAATGATTTCTCTATTATATATTATACTGATGCAAATCAACGAACTTACCACGCTGGCGACGCTCATCAATCATACGTTGTAGCTTTGCCTTGCGATGTGGCGCAATCCATTTTTTCGCAAAAATGTTAGGAATAGCAACACCAAGAGCAATACAAACTAAGACTAACGAACCATTGATTGCAAAAGACATAGCATGCGTTACTTCTCCAACAACACCCTGCATCCCCATAAAACCATAAAGTGCACGATACATTAATACACCTGGAACAATAGGGATAACAGCAGGAATAGTGATACACTGATGTGGTGTATGGAGGATATGGACAGCCTTAATATTAATGATAGATATCAATGCCGAGCCACAAAGTGAACCAACAACTATTCCAAGTCCAAGACCAGCATTTCCTGTTGAAGGGTCAAGGAAAACGAAGTTACGCGTACAAACACAGATTATACCTCCAACCGCAATCCAAGGCATTAAACGATATGGAATATTATAAATCGTTGCAAAGCCCATAGCAGAAATTGCAGCAGCAACAGCATAGACATAGAAAGAGTGATGAGGAATAGTAGGGAGGTCTTTTGCAAAACCATCAAAACTACCACACTTAATTGCCAACATAATACCAAATGACATTGCTATGACAATAAGAAGCGTGTTCATTGCACGGACTAATCCCGTGTTTATATGATTGTCTAACAAGTCATTAACAGCGTTTATTAAAGGGACTCCTGGAACAATATAAAGGGCACAAGCTAAGAGTGGATGCCAAGGAGTTTCTGTAAACAGAATTGGACGAAGGAACTCTGGTAGCGCTGCTTGAACGGTAGGTGTAGAGAGAAAAGACGACAACCATGCAAGAATTGTACTAACAAAAGCCGCAACAGCAAAGTTAGCATAAAGATTAGAACCAGAATGATTCAAGAACATACGAAGACGATTACCCAATATAGCGGCAATAGAAGCATAGAAGAAAGCTGTCCAATCACAACCGAACTGAATACAGAATCCACCACAAGCAAGTCCTGCACCAATAGCAATTATCCAATCCTTGTAATAGTGTTTACCATTAGCAATCTTCTCAAGTTCCTCTTCATACTTGTCTAACGAATAGTCCTTTTGAATAGCACGCCATGAGAGTTTTGAAACTTCCTGAATAGCAAGCATATTAATTACATGCTTATCACAACGCTGCATCTTAGAAAAACTATGATATTCGTCACTAACATTCACCTGCAACATATAATAATCAATGTTCATGTGCAGATTCTCTTTGGGAAGTCCCAAATAAGCTGCTGTACGCTCCATATTTCGCTTCACACGACTCGTATCAGCAGAACTTTCCATAAGAATTTGCCCTGTACGAAGGAGCAAATCGAGTTTTCTACGAAGGGTTTTCTTGGAACAATCCATCTGTTTTTCGTCCATACAAAACAATCTTTAAACTTTAAAACTTTTGCAAAGGTACAATTTATTATCCGTATAGGAAAATTACGCTGCTAAAAATCAAATCTTTAGCTTAATAATTATAGAACTTTGTTCTCAATAGTAAAAAGCTCATCAGCCTTTTCGAGTAATACTACTATAGATTTTTATGACGCAAACCCCTACACTCTTTTAGACCTATTCGTAATAAACAAGTTTTCTTATGCTTAGTAAATCTGTACATCGTAACCGTCCGCACCATTGGTGTTCACCGCCCGCACAAGATGTGCTAACCCTCCGCACAATATGTGCTGTCCCTCTGCACCAAATCATTTCACAAACAGTAAAATACGGTTTAATAGAAGTTTGAGAAGGTATATATCAAAGAGTCGATGAATAAAAACAAACGGGTTTCTTTCCCTCTCCTTATTCTTCAATGCCCAAAGAATCTTCTATCAATGCCGCAACGATAACAATTTTCTCGTAGAAAACGAAGTGGACGAGAAGAATCCGAACTATAAACATTGAGTTTCTTACATCTTCGTTAGGGAATCACTTCAAAGCAGTTTTTCATCGAGGCGTTAATACCGACAACATTCTGGTAACCAAAACCTTTCTGTAGGATAAATCGATTTTAATAGAGTGTTGTAACTATGAAAATAAAGCTTCTCAAATAATTATAAAATGCAAGATGTACAATAAAACAAATAATCTTCAAAAATAAATTCCGATTTCTTTGGATTTCTCAAGAATGTTATATATTTTTGCTCAAATCGTTATGAGAAAATATATATTTACTGCCATTATAGTATCTGTAACTTTAACGAGTTGCTTTAGTTTCTTCCCTAATCGGTACGAGAAAGCTCTTGTATACAATGGTTTTCGAGCAAATACCAATACAGGGATAGCTACAAAAGTGAACATAAAAGGCTACTATTCTTTAGTTAATGATAGCACCGATTCTGTTACCGTAGGAGGTTCTTCTATCATTAGCAAGGGTGGCATGTCAACGCTTGCAGGGTATAATCCTTTTATCCTTTATGAGGACGGAACATACGGAAATATTCTTTTCAATGCTGTAGAAAAGGATTTTTATGCCAATGAGCATTATAAGAGAGCTAATGTGGAATTGTATAAGGAGTGTACTCCTTTGAATAACATATATCTTATGAGGAGTGGGTATTATAAGCTAAAAGAAGATACAATCTGTGTAACGACATATATATATTATTTACTACGCACAGAACTGGTATTACTGAGGTATAAAATCATTGATAGTAGTCATCTGCTACTTTTAGATGAGACTTATATTTCTGGAAATAAAAATGAAAACGATACTTGTGTTCAGAATAGGATATTTGAATTTATCCCAGCTAAAACACTTCCTTCTCCATCTTTGTTCCCAATTAAAAAGAAAAGGTGGGCTTGGGCTAACAAGAAGGATTGGAAACAATTTAAGCATAGTATTGCAAGAACATCAAAAAACAAATAAGAATATACTATATTTTTTTACAAGTTTATCAGAGATACATTTTATAGCAGTTATTGCGGGTCTTCAGGATTTTGGAGTGATAAGGTTTGTCACTTAAGGTTAGGTTTCTGACGAAATGTCACACGAGAAAAGGAGAGGACGGAGGATTATCAAAACAAAGCAATGGAAGTCACGGAGGCACCGTCGGTGCATAGAGTGACGGAGTCTGTTTGCCAATTCTATTAGCAATTTATATACAAAACGTTTATCCCCAAACAGTTATCAAGAACCTGTATGCTACACCTCCGTCGCTCTTTGTGCCGTCGGCACCTCTGTGACATTGTGTTTACCTCCGTCCTCCCCGTAGCTCTGTGTGCCTTATTATATAATCGTTTTAGTTTATCACTCCATATTTCGGAAGAACAAAAAAAACACTTGATTATGAAAAAAATCATCTTCTCAGTGAAATAAGTCTATCAATCCTTCGTTGTTACAATATAAATATAGTACCTTTGTAGATAATGAGTTTTATAAATACTGTAAATACAGAAGACCTTTACCACAAAGTTGCACGACTTATAGAAGATAGTCGCGCTCGTATGGTTACATCAATAAATTTAGCAGAGGTATACACAAAGTTTCGTATTGGACAATATATTGTAGAAGAAGAACAACGTGGTGAGACAAGAGCTCAGTATGGAAAACAAGTTCTCCAATCGCTTGCCACTAAACTTACCAAAAACTTTGGTAACGGATGGAGCTATTCTAATTTGCGCCAAATGCGACAATTCTTTGTAATATATAGCAATTTGACAACCACTGGCTGTCAAATTGACGATTTTACTCCAAAGTTCACATTGTCGTGGTCGCACTACTTGCTTCTAATGCGTGTTGAAGACCCCGATGCTCGCAGGTTTTACGAAATAGAAAGTTCACAACAACAGTGGTCCAAACGTCAACTATCAAGACAAATAGGAAGCAGTCTTTACGAAAGACTGGCTCTCAGCCGAGACAAGGAGGGAGTGATGCGGCTTGCTCAAAAGGGGCAAGTTGTAGAGAAGCCATCCGACATCATTAAGGATCCAATTACGTTGGAATTTTTAGGTTTAAAGCCCGACAGCCTATACTCTGAGTCAAAATTAGAGAATGCCATAATCGGACGTATGCAACAATTTTTATTGGAGTTAGGGAAAGGGTTTCTTTTTGAAGCACGGCAAAAGCGATTTACCTTTGAAGAAAGACATTTTTATGTGGACTTAGTCTTTTACAATCGATTATTACAATGTTATGTATTGATAGACCTTAAGACAGGAAGCTTATCCCATCAGGATTTGGGACAGATGCAGATGTATGTCAACTATTATGATCGCTATATCAGACAAGATTTTGAAAACCCAACAATCGGTATTTTGCTCTGCGAGAACAAAAACGATGCATTAGTAGAACTTACTCTGCCCCCAAATGCAAATATCTATGCTTCTGCTTATCAATTGTATCTTCCCGACAAAACTCTGCTACAATCAAAGGTCAAAGAATGGATTTCTGAATTTAGAGACAACGCTGAATGATATGAAACCAAATATAGATATTAGTGAAAACGAACTTCTACGGCAATCAGAAGAAATACTTGTAGAATTACTCAGAGACCACACGACGCAAAAGAATATCTTTTGGGCTACGGACGATTATGCCTCTTTAGGTGAGGCATATAGTTATCATGCACCTATCACAATACCTTGTATCACCGGTGATAATGGTTTTATCATACAACCGAGAGTATTAAAAACTCGAGAAGAACAAGCGAACCGAACCAAAGACAAAGCTGAGGTTTTTACGCCTTCTTGGGTGTGCAATGCGCAAAACAACCAGGTAGACGAGGCATGGTTTGGGCGCAAAGATGTTTTTAATCACGAGCACCCCGAAACCAAAACATGGACAGCCACAACTAAACCAATCTTGTTTCCTGACGGTAAAACATGGAAGGACTATGTTCGCTCCACCCGCATGGAAATCACATGTGGTGAAGCCCCCTATCTTGCAAGCCGATACGATACGACTACAGGAGCTTTTATTCCATTATCACAACGTATAGGTATGCTTGACCGTAAATTACGTGTCATATCGGAAAATACTACCACTACTGGAGAATGGCTCAAAATGGCACAAGAGGCATATAAGAATATCTATGGCTATGAATGGCAAGGAGACAATCTCCTGCTTGCTCGTGAAGCACTACTCATGACTTTTATTGAGTATTACACAGAAAAGTTCGGAGAGAAACCCCAAGAACGTTCGATAAAATACATTGCCTATATTATAGCTTGGAATATTTTTCAGATGGATGGGTTGAAAGGAGTAGTTCCCGATAGTTGTAGACATAATGAGGTCATAATTGAACAAACTCTTTTTGAAGCAATGGAGCGAACCGTGCTTTGTCCCGGATGTCAGAATGAGACCTATAAAGGACACAACGGGATATACTGCCTCATCCGTGACTGGGGACATAAAGACCCAGTAACAGGAGAGAACAATCGAAAAATACGTTTCATTGACTTAATAAAATAACAACTTAAAATATCAACCTATGGCTACTTTTGAATCATCACTCAAACCTCGATTGATATATGTTTTTGCTATTGCTGACAAACAGCATGAAGGTAGTTTGAAGATAGGAGAAACAACGCTTGGTGATGATACTGGAGATACGTTGGCAGCACCCAATAGCGATGTCCTTAACCAGGCTGCCAAGGCTCGTATTGATCAATATACGAAAACGGCAGGTATCAGTTACGAACTTCTGCACACCGAACTTACGTTTTACATCCGTGGAGGACATATCTGTTCCTTCAATGACAAACAAGTGCATAATGTCTTAGAGCGTTCGGGCGTAAAACGTAAGGAGTTTAAAGGAGCTACTGAATGGTATTCCTGTGACTTGGAAACCGTAAAACGTGCCATTGCTGCCATCAAGGAGGGCAAGGACAGTTTGGGGGCAGGCGAAGTGACTCACACTGAGAATCCGATTATTCTCCGACCAGAACAAAAGGACGCCGTGGAGCGTACGCTCAAACAGTTTCGTCGGGGCAATCAGATGTTATGGAATGCCAAAATGCGTTTTGGTAAAACCCTATGTGCCTTGCGTGTAGCTAAAGAGATGGGAGCCGTCCGTACTATTATTGTCACTCATCGTCCTGTGGTAGACGCCAGTTGGTTTGAAGACTTCGGAAAAACATTCCACGACAGTCCTGAGTGGCATTATGGTTCACATAACAAGGGGGAAAGCTTTGCCTCGCTCCAGCGACTGGCTGGTCAAGGAAAGAAATATGTCTATTTTGCTTCTATGCAAGATATGCGTGGCTCTAAGGAAGTTGGAGGAAAGTTTGACAAAAACAACGAAATATTTTCAACTACTTGGGACTTGGTTATTGTAGATGAGGCTCACGAAGGTACGCAAACCGAATTAGGAAAGGCTGTCTTAGAACAACTGATAAGCAAAAACACTAAGATATTGCGCCTATCAGGCACACCTTTCAATCTGTTGGACGACCACAAAGAAGAGGAGGTCTTTACGTGGGATTATGTTATGGAGCAAAAAGCCAAAATAGACTGGGAAATCAATCATCTTGGTGACACCAATCCATACGCTTCGCTACCCGCTATTCACATATACACCTACGATCTTGGGCGGTTGATGAGTGAATATAGCGACGAAGAAAAAGCCTTCAACTTCCGCGAGTTCTTCCGCACACGAGAAGATGGGAGCTTTGTACACGAGCGAGATATTGACCATTTCCTCACACTCCTGACGACTGATGATGAAGAATCGCTCTATCCTTACTCTAACGACAGCTTTAGACAAATTTTCCGACATACCCTTTGGATTCTGCCGGGTGTAAAAGCCGCCAAGGCTCTCAGCAGAAAACTGGCTAAGCACCCTGTCTTTGGACTCTTCAACGTGGTTAACGTGGCAGGCGATGGCGACGAAGAGGAAGAAAGCCGCGACGCACTTGAACTTGTTAATAAAGCCATTGGCAGTGACCCTGACCAATCTTATACAATAACCCTCTCCTGTGGACGTCTTACCACGGGTGTAAGCGTAAAGCCTTGGACTGGTGTGTTTATGATGGCTGGTGCTTACAGCACTTCGGCAGCAGGATATATGCAGACTATCTTCCGTGTTCAAACACCTTATACTCATAATGGACGTATGAAGACAGACTGCTACGCCTTCGACTTTGCTCCCGACCGCACGCTGCGGGTGCTTGCTGAGACTGCAAAAGTATCGCACAAGGCTGGAAAGCAAACCGAAGATGACCGTAAATTGCTTGGCGACTTCCTTAATTTCTGTCCTATTATTGCCATTGATGGTGGGCAGATGAAACAATACAAAGTGGAAACTATGCTTGCCCAACTCAAGCGAGCGCAGATAGAAAAGGTGGTGCAAGATGGTTTTGAAAATGGTGCACTCTACAATGACGAATTACTCAAACTCACAGATGTGGAACTCAAAGAGTTTGATGACCTCAAAGGCATCATTGGCAAAACCAAGGCAATGCCTAAGTCGGGAGACATCGACATCAACCGACAGGGACTGACCAACGAGCAATACGAGGAGAAAGAACAACTTGAAAAGAAAAAGAAGAAAGACCTTACGCCAGAAGAAAAAAAACGACTCGACGAGCTTAAAGCAAAGGGCGACCAACGGCGGGAGGCTATCTCCATTCTCCGTGGTATCTCTATCCGTATGCCGCTTATGCTTTATGGTGCCGAAATGGTGGACGAGGACAAGGAACTGACCATCGACAACTTTGCTAAGCTTATGGACGACCAGTCTTGGGAAGAGTTTATGCCTCGAGGCGTAACCAAACAAGTGTTTGCCCGTTTCAAGCGTTATTACGACCCCGACATCTTCCGCGAGGCTGGTAAGCGCATCCGTGAAATGGCGCGTATGGCAGACAAGTTTACCATTGAGGAACGTATTGCCCGTTTAGCAAGCATCTTTGCCACCTTCCGCAACCCCGATAAAGAAACGGTGCTCACGCCTTGGCGTGTGGTAAATATGCATCTTGGAGATAGCCTTGGAGGCTACTGCTTTATGAACGAGGACTTCACCTCCAACTTAGATATTCCTCGCTATATTGAGCATAAAGGTGTCACGACTGAGGTGTTTCATCCACAGAGCGTCATTCTGGAAATTAACTCCAAGAGTGGTCTCTATCCCCTCTATGCAGCTTACAACATCTATCGCACCAGATTAGAGCAGGCTCGTGAGAAGTATGGAGAAGTAAATCGTGCCACGGCACTTATGCTTTGGGACTTGACCTTAGAGGAAAACATCTTCGTCGTCTGCAAAACGCCTATGGCACGCTACATCACTATGCGCACCCTACGAGGTTTCCGCAATACGAATGTGCATACCAAATATTATCCCAACTTAATAGAAAGCATTATCACAGAACCCGATAGCGTGGTCAATATGTTGCGCTCGGGTAAGAGATTCTGGAAAATAAATAATGACGAAAATATGAAGATAGACGCTATTATAGGCAACCCACCGTATCAGGTGACATCCGAAAACACAAGCGATGCTCCTGTTTATCATTTATTCATCGATCTTGCAAGCCTTTTGGCGCAAAGAGTCTCGCTTCTGACTCCTGCTCGCTATCTGTTTAACGCAGGCAAAACGCCAAAGGATTGGAATACTAAGATACTTAATGACGAGCACTTTAAGGTGGTTGATTATTGGGCAAATAGTACAGATGTGTTCCCAACAGTAGATATAAAAGGAGGAGTGGCTGTTATGTACAGAGACTCTAAGCTGAATTTTGGAAAAATTGGTACGTTCACAGCTTACAAGAAATTGAACATTATTGCAAATAAAGTATGTAAGATAAGTGAAAACGGATTGTTTGCAGAACTAATATATGCGCCCGAAAGTTATAGATTGTCAGATAAATTACACGAAGACTATCCTTGGGCTAAAGAGCGTTTAAGTATGGGACATCCATACGATATAACAACCAATATTTTTGAAAAACTGCCCGAAATATTCAAAGAGACTTATCAAATAAAGGAAGAGGAAGTTAGATTCTATGGTAGATATAAAAACGAACGTTGCTATCGTTGGATAAAAAGGGAATATGTTGATTTCCACCCGAATTTGGATAAATATAAGGTGATTGTTCCTAAAAGCAACGGATCGGGAGCAATCGGAGAAGTACTGAGTTCACCGCTCATAGGAGAACCACTCATAGGAGTTACTCAGACATTTTTAACAATAGGAGCATTCGATACTCGGACAGAAGCAGAGGCTTGTCTCAAATACGTCAAGACAAAGTTTGCCAGAACGATGCTGGGGCTACTTAAAGCAACGCAACACAATCCCAAAGACACTTGGCGACTTGTACCATTGCAAGACTTTACCGCAGCGTCAGACATTGATTGGACACTTTCTGTTGCAGAGATAGACCAACAACTTTACCACAAATATGGGTTGGAAGCGGAAGAAATAGCCTTTATTGAAGAAAAGGTGCGAGCAATGGGGTGAAAAAAAGAGGCAAGTCATCATAAGGCTTGCCCTTTTTGGTTATCGTTCTGAGAGTGTTTGTTTAATGATTGCTTGCATCTCCTCGTCTATTCCAAATAGTCGATATAACTGTGTATTTACATCTTGTGCGTAATCTATTATTCCATTATCGTTCGTATAGTCCAATAAATCGGGTACAAGTTTCCCCAAAGAAGTTAAAGCTTCATCGGTTAGCAAGAATGCGTAGCGTATGAAGTCTGTTTGGCAGTAAGCATAGAAGTTTCGTGCTTCCTGCTCTGTTTCAAATGTTTTGAGGGCAACACGTGAACGGCCAAAGACAGAGTGATTGTCAAGCACAGCAATCTGATTGCTTCGTTTCTGTCCGCCAGCATTTGCGCTCGATACAATGACTTTCCACCGATGCAAATAGTCTAAGCCAGTTTTAATTACCGATTTATGAGCAATGAACCAACTTGCTCTCCCTGCCTTTCCTGCTTTGTCGTTCGTAAACAACTTTATTTCATCTTCGCCAAGTATTATTCCTTCTTGTAAAGGGCGTACTAAGGTCGGATTTTGCTCAACAAAATCGCTCTCTATAGAAAATAGACTGCGAGGAAGAACTGACCCATAGATATATTCAAAATGATGCTTAATGACAATGGCTTGAATCTTTTGACTGATTTGCTCGGCTATAGGATCAAGTGCCATTAAAATATCACCAGGGTTAGACATTGCAACTTCCATAGTTTTTCCTCCTTTGCTGTAAGCATAGATAAAGCCCTCTTTTTTCTTAGCATAATCCATAAATACAATAGAGAGTCCATCGGCAATGCCGACATCTTGGAAAATATCTGTAGAGTCAGGAAAGAAATGAAGACGGCAAAGCCTTCTATCGTTGATTTGATTATATTGGTGTCCGATAAAACTTTTTTTGCGTTCATATCTTTTTAATTCAGAATAATAAAAAAACGGGCTGATTGTTTTGCACATTCAGCCCTTCTTATTTCCTTTGTAGTTGTCATAATAAAACAATGAAATAAGATGAACAAAAGTACACATTTTATCGGACAGCCACTATATGTTCAACTGTTAAACTATTTTAATCGTGATAAAATTCTCTCTCTGAGCCAAGCTCAGGGAGGTGAACACTATATAAAGAAGTTTGATGCATGGCATCATCTTGTTGTCATGCTTTATGCAGTAATGCTGCGTTTAGACTCTCTGCGTGAGATAAAAGCCTCTCTCTTTGCTAATGTTAATCGCTTTAATCATCTTGGTTTAAAGCATTTCCCTTGTCGAAGTACCTTGTCAGATGCAAATAAACGCCGAGATTCCGAGATATTCGGTTCGATCTATATGAACCTATATGAGAAATACCGCCATGAGCTTTACTCGGACAGCCGAAATTGTGGACAGCCTAAATGGCTGAAGAATCTAAAGATAATAGATTCTACGACAATAAGTCTGTTTTCTAACTTGGTCTTTAAAGGTGTAGGACGTAATCCCAAAACTGGTAAGAAGAAGGGTGGAATAAAAGTACATACAGAGATATTTGCCAATGAGAATGTTCCAAGCGATATTAAGTTCACATCTGCAGCTAGTCATGATCAGTTTGCACTTATCCCAGAACGATACGCCAATGAGGACCTGATTGCTTTTGACCGAGCCTATATAAACTATGAAAAGTTCTCTGAACTGACGCAAAGAGGCGTTATATATGTAACTAAGATGAAAAATAATCTTAGCTTTGAAAGGATTGCTGATACAGATTACCAGATGACTACAGATTATGGAGCTGTACGCGTAGAAACCATTCTCTTCCATAAGCATACAAAGGAAAAAGATATTTACCATAAAGCAAGAAAAATCACATATCAGGATAAGACCAAGAAAGGGAAAATCAGATTCATATCTCTGCTGACCAATGATTTTCAGATGTCAGCAGAAGATATTATAGCTATCTATAAGAGACGATGGCAAATAGAAACCTTATTTAAACAAATAAAACAGAATTTCCCGCTAAGATACTTCTATGGAGAGAGTGCGAACGCTATAAAAATACAAATATGGATTACACTTATAGCCAATCTGCTTATAACCCTAGTGAAGAACAAAATAAAGAGACCTTGGAGTTTCTCAGGCTTGGCAACAATGATAAGAATTCTACTTATGAGTTATGTCTCAATACAGAGTTTCTTTGAACGGCCACATAGAGACTGGGATAGATTGATTACCCAGGTAAAAGCCCCACCAGAAGAGTTGTCATTATTCTAGTGGGGGGGCTTGGAATTTGAAATAAGAACAAATCATGCCTATTTCAGCAGGATTGAGAGAGGATATTGCAGTATATAGAGGTTTTATCGGACAGCAATAATTTGATTATAGCCAAAATTTGCCAGTCCCTTGCCTGAACGATGTATCCACCGCCCAGCAGGATAAATGAGCGAGGAAAAACGTGGAGCAAGTCTGTCGGCAAGTAATTGGAAATGTTGGAATATATTTACAACAGCTTTTTGTCCATTATCAGTATCTTTCTTTGCTACAGTCAGCTGATACGGTGGGTTGCCTATAATAGCGTAAATCGGCGAGATTTTTGCAATATTACTTAGATACAAAATCAAATAATATGGTCAAATCATTTAAGCAACAACTCAAGAAAGAAGAATTATCGGACAATACGATTACAGCTTATCTGTATGCTGTAGAAGACTTTGAGCGAAAGTATTCTTGCTTCAATCGAGAAAATCTTTTGCTTTACAAAGCAGATCAAATAGAACAATTTAAACCCAAAACTGTAAACCTTCGCATTCAGGCTCTCAACAAATACTTAGAGTTTATCGGTAAACCTCGCCTTCGTCTCAAATCTCTCAAAATACAACAGAAAACTTATCTCGAAAATGTGATTAGCAATGCGGACTACCAGTATCTCAAGTCAAAACTCAAAGAAGGAGAAGAGGAAGTATGGTATTTCCTCGTTCGTTTCTTAGGTGCTACAGGAGCTCGAGTAAGTGAACTTATACAATTCAAGGTCGAGCATGTGAGAGTGGGTTACTTTGACATCTATACCAAAGGAGGGAAGGTTCGTCGGATCTTCATTCCGCAAGATCTCTGCATGGAGACAAAAGCATGGTTGAAGCGTGCCAATATAGATCTTGGATATCTATTTTTAGACAAACACGGCAAGCAGATTACTCCACGAGCCATTCGACACAAATTGCAACGCTTCGCCCATCAATGGGGTATAAATTCCAAGGTGATGCACCCTCATTCCTTCCGTCATAGGTATGCAAAGAATTTCTTAGAATCGTTCAATGATGTTGTTCTATTGGCAGACTTAATGGGGCATGAGAGTATTGAGACCACTCGAATTTACCTGCGTCGTACTTCCAATGAGCAACAGGCTATTGTAGACAAGATAATTACTTGGTAACCTCTTTGACTTGATAAACTATTGTTAGTTGTAGCAGTCTCTCTGTGCAATGATTTCGTTCTCAACATAGTTCATTTACTTTTTGCGCTCAATAAATCCGTAATGTCTCTCTCTTTATAATAACAATTGTGTTCTATCATTGAATGAGGAATTTTTACCCATATCTCTGTATGATTGCAAGGTACACTTACTGATAATCAAATGCTTACATGAATCTTCGTTATCAATCCACCCCTCACTATCGGGCGGATTGCCGAAGAGTTGTTCGATACGATGAATAAAGTTTGCAGAACAAAACAATTTATTCAAAATGTATTTTCCTGTCACTGATATCATCAAAAAGAGCCTATAAACAATTGATTTGCAGCACCTTTATATGAAATGTTAAATGTGACAGCAAAATAAATTTAAAACAACAATGCTTATATCACCAACTTTAGTCTGCTTTATTACTCCGCATATCGGAAACCTTAATTTAACTGTATAATAGCTTTTCGAATATTCTCTTTTGCAACGGTAGGTTTCATTGCTTCTGTAAGCATCATATCTGTTGGTGTAATACATTGGACTTGTGAGAAGCCTGCTTTAAGTAAAGCTGCCGCATCCTTTACCTTCCCAGCTATAAGCATAACAGGAACATTCTTACGAAGACCATATTCTAAAACCCTTATCGGTATCTTTCCCATTAATGTCTGACTATCTGCACTACCCTCCCCTGTTATAATCAAATCTGCATCTTCTATAAGTGAATTAAAATTGACAGTTTCTAAAAGAACATCTGCACCAGAGCTCATCTTGGCATTCATAAACTGCATAAAAGCATAACCCAATCCACCTGCAGCTCCAGCACCGTTATTCAAAGAACAATCAAAACCTAACTGAGCAGCAGCCATACGTGCAAAAGTACGTGCTCGACGATCCAAACAAACTATCATTTCTGGTGTCGCTCCCTTCTGTGGACCAAAAATGACAGCAGCACCACGTTCACCAAAGAGAGGATTATTTACATCTGAAGCTAAGGTTATATCTAAATCTCGTAAAAATTTATCACGCCAGTTCTTACCAAAAATGTCTTTCAAAGCTGCCAACATACCAAGTCCGCAATCGCTTGTAGCTGACCCTCCAAGTCCTACAACAAACTTTCTATATCCTCTTTGAAGTGCATCAGCAAAGAGTTCACCTAATCCATAAGTGGTTGCACGTAAAGGATTCAATTCCTGTTGCTTAAGAAAATTTATGCCACACGACAAAGCCGTCTCTATAACGACCGTATTATCTGCACATACGGCATAGCTTGCTTGAATGGGACGCATGAGTGCATCGTGGCAATTAATAGTAATCTCCTTACAGTCGAATAACTGTAAAAAGACTTCTAACATTCCATCTCCCCCATCCGTGACAGGAACCTTTACAACCTTAACTTCCTGCCACCGCTCACGAAGACCCTGTTCAGCAGCATCTTCAGCTTCAACAGAAGAGAGACAACCTTTAAAACTATCAATAGCTAAAATAATATGCTTCATATTGCTTACAAAGTTATTAAGAATTCGTGAATAATTTGGATTTTACATCTATTATATATATCTTTGCAAGATAAACTGTAATTATATACCTTTATATGAAACAATTTTTCAAATTCGTTTTTGCTTCTTTCTTTGGAATGATGTTGTTTAGCATCGTTACAGGACTCTTTGCACTTTTCACTATTGTTGGTATGATTGCATCGCAGGATACAACCAAAGAACCTGAAGACAACTCAATACTTGTATTGAATCTTTCAGGACAGATGTCAGAGAGAAGTGAAAATAATTTTCTTAGTCAGCTACAAGGTTCTCAAATAAATAGTTTGGGTCTTGACGATATGCTTGAAGGAATCAGAAAAGCTAAAGACAACGATAAAATAAAGGGTATATACATAGAAGCAGGTGCGTTTGCGTCTGATTCATATGCTTCTATGCAGGCATTGCGTAAAGCACTACTCGATTTCAAGAAGAGTAGAAAGTGGATTATTGCTTACGCTGACACCTATACACAGGGTACATACTACTTGTCGTCTGTTGCTGATAAAGTTTATCTTAATCCACAAGGACAGATTGACTGGCACGGATTAGCTTCTGAACCAGTTTTCATTAAGGACCTCTTGGCAAAATTCGGTGTAAAGATGCAGGTAGTAAAGGTTGGTGCTTACAAAAGCGCAACCGAGATGTTCACTGGCGACAAGATGAGTGATGCTAATCGTGAGCAAACATCAGCCTATTTAAACAGTATCTGGGGCAATATTACAAAGGAAGTTGGAGCAAGCAGAGGTTTGTCAGTAGCACAACTGAACGCATACGCTGACAGTATGATAACCTTTGCTGACCCACAAGAATATGTAAAATTAAAGCTCGTTGATGGCTTAGTTTATACAGACCAGATAAAAGGAATCGTCAAAAAGCAATTAGGTATTGAGGCTGACAAAGACATCAATCAGGTTACTATTGCTGACATGGTGAACACTGAGGACAAAAACCAAGGTGATAAGGAAAATGAAGTTGCAGTCTACTATGCTTATGGTGATATTGTTGATGGTGTTGTAGGAGGTCTCTTCTCACAAGGTCATCAGATTGACGCACAAGTTGTTTGCAAAGATTTGGAAGAGTTAGCAAAAGATAAAGACGTTAAGGCTGTTGTCGTACGTGTCAACTCTGGCGGCGGCTCCGCTTATGCATCAGAGCAAATCTGGCATCAGATTATGGAACTGAAAAAGTTGAAACCTGTCGTTGTTAGTATGGGTGGAATGGCTGCTTCTGGTGGCTATTATATGTCAGCTCCAGCCAACTGGATTGTTGCTGAGCCTACTACAATTACAGGCTCTATAGGAATCTTTGGTATGTTCCCTGATGTTAGCGGTCTGCTAAGAGAAAAACTGGGTTTAAAGTTTGATGAAGTTAAAACCAACAAATATGCTGACTTCGGCACACGCGCTCGTCCTTTCACAGAAGAAGAAATGTCATATCTTAGCCAATATGTAAACCGTGGCTATAAACTCTTCCGTCACCGTGTGGCAGAAGGACGTAAGATGACTGAAAAACAGGTTGAGAAGGTAGCACAGGGGCATGTGTTTACTGGTCAAGATGCACAAAAGATAGGACTTGTTGATCAGCTTGGTGGATTGGATGTTGCTGTAGCAAAAGCTGCACAACTTGCTAAACTACCAAATTATAGAAAATGTGCTTACCCTAAGGAGCCTAACTTCTTAGAGCAAATGATGGAGCAAACGAATCCTAATAATTACCTCAGCCAACAGTTACGTGCTAACTTAGGTGACTATTATGAGCCATTCACACTCTTAAAGACCATCGATCAACAGAGTGCAATTCAGGCACGTTTGCCATTTTATCCTAATATCCATTAATCATATATGGAAGGAGACCACATCAAAATAAACAAATGGCTATTGCCTTTCAGCTGGCTCTATGGGCTTGGAGTAAGACTGCGCAATGAGTTATTTGAACTGAACATTCTCAAATCCCGACAGTTTGACATTCCAGTCATATCTGTTGGTAACATTACTGTGGGTGGTTCAGGGAAAACTCCCCACGTAGAATATCTTATCCGATTACTGAAGGATAAAATGAAGGTGGCTGTTCTCTCACGTGGCTATAAACGTAAGAGTTGTGGATACGTATTAGCAAACGAGAATACTCCTATGCGGGAGATTGGTGATGAACCCTATCAAATGAAGACAAAGTTCCCTGATATTCGTGTTGCAGTTGATAAGAAACGCTGTGAAGGAATAGATCGGCTAACATCTGATGAAGAAACAAAAGATACAGATGTTATTCTCTTAGATGATGCTTTTCAGCACCGATATGTACATCCCGGTATCAATATCCTGTTAGTTGATTATCATCGACTTATCATCTATGACAAACTTCTTCCTGCAGGAAGACTACGTGAGCCACTCTCTGGAAAAAATCGTGCAGATATTGTTATCATCACGAAGTGCCCAAAGAGTCTAAACCCAATAGACTATCGTGTATTGAGTAAAGCTATGGAACTCTACCCTTTCCAACAGCTTTATTTTACGACGTTAGACTATTGTGATTTGGAACCTATCTTCAGTAAAGGAAGAAATATACCACTCACAGAAATAAGAGGAAAAAATATCTTGTTGCTTGCTGGTATCATGTCACCAAAGCAATTGGAGTTGGATCTAAACTCTTTCACAGGAAACAATGCACTGACAACACTATCGTTCCCAGACCATCATGCATTCACAACAAAGGATATTCATCGTATTAACGAGACCTTTGCTAAAATGCCTGAACCAAAATTGATTGTCACAACAGAGAAAGATAAGGCACGTCTTGTTGATATTGATAAATTATCAGACGATGTAAAAGAAAACATTTATGCACTTCCTATCAAGGTAAGCTTTATGCTTGACAAGGAAGAGGTATTCAATAAAAAAATAATATCCTATGTACGAAAAAATTCAAGAAACAGCATCTTGGCTAAAAGAGAGGATGACCACAAGTCCAAAGACAGCCATCATTCTGGGCACAGGCCTCGGACAATTAGCTTCAGAGATAACCGATAGCTACTCATTTTCTTATCAAGATATACCAAATTTTCCAGTGTCAACAGTAGAAGGTCACGCTGGTAGCCTTATCTTTGGACGACTTGGTGGTAAGGATATCATGGCTATGAAAGGTCGCTTCCACTTCTATGAAGGATATAACATGAAGGATGTTACCTTCCCTATTCGTGTAATGCACGAGTTAGGCATTGAAACATTGTTTGTTTCAAACGCTTCTGGCGGTATGAATCCATCGTTCAAGATTGGTGACCTCATGATTATTACAGATCATATTAATATGTTCCCAGAACATCCGCTACGTGGTCGTAACTTCCCTACAGGTCCTCGCTTTCCAGATATGCACGAGGCATACGACCATAAATTGGTTGATTTAGCAGACTCTATTGCTAAGGAGAAGAACATCGAAGTTCAGCATGGAGTTTACATGGGCGTACAAGGACCAACCTTTGAAACACCTGCAGAATACCGTATGTACCACAAGATGGGAGGTGATGCTGTTGGCATGAGTACCGTACCAGAGGTTATCGTTGCTCGCCATAGTGGTATTAAGGTGTTCGGCATCAGTGTAATCACTGACCTTGGTGGCTTTGATGTTCCTGTAAAAGTTAGCCACGAAGAGGTTCAGGAAGCTGCAAACGCTGCACAGCCACGTATGACAGAGATTATGCGTGAGATGATTAAACGCTCATAAGGCATATAAATATAAAAAGAAACTAAGGCGTTCTTTATTCTATAATTCATAGATAAAGGACGTCTTAGACATTATATCAATAAGCTATTAATAAAGTAAATGGAAATAAAAGACCTTGGTGAATTCGGACTAATCAACCGTCTCACAAAAGACATACAACCAATCAACAACTCTACCATTATGGGCGTGGGTGATGATGCTGCTGTTTTACACTATTCAGATAAAGAAACACTTGTTTCTTCACAGATGTTCATGGAGGGTGTACAGTTCGATTTAACTTACATAGACATGGAACATCTTGCCTACAAGGTGGCTATGATAGCTATGAGTAACATATTCGCTATGAATGGACAGCCACGGCAACTCATCGTTTCATTAGGGCTTGGAAAACGTTTCAAAGTAGAAGACCTTGATCAGTTCTATGCTGGATTGAACAAAGCTTGTGCTAAATGGAATGTAGACATTGTTGGAGGTGACACGACTTCTTCATATACGGGACTTGCTATTAACCTCACTTGTATTGGTGAAGCTGCAAAAGATGATATCGTCTATCGTAGTGGAGCAAATGAGACCGATCTTATCTGCGTTACCGGTGACCTTGGTTCGGCCTACATGGGCTTGCAAATTCTCGAACGTGAAAAGACTGTTTATTACCAACAAGTGCAAGAGTATAATAATAAGGTAAAGGAAGCGCAAAGCAATAAAGACGAGAAACGACTTGAAGCATTACGCCAGGAACGAGCAGCAATAGAGGATTTCCAACCAGACTTTGCAGGAAAAGAATACCTTATTGACCGCCAGTTGAAACCTGAAGCACGTGGTGCTGTACTCAGTCAACTGCGTACAGCAGGCATACATCCAACCTCTATGATTGATATTTCAGATGGATTGGCAAGTGAATTAAAACATATTTGCGAAAAAAGTCACTGCGGTTGTAGAATTTATGAAAAGAATATTCCTATCGATTATCAAACTGCAGCAACCTGCGAAGAGTTCAATATGAACCTTACAACAGCTGCTTTAAATGGTGGAGAAGACTATGAACTTCTTTTTACAGTACCTATTGGCGATCATGAGAAGATTGATAAGATGGAGAATATCAGACAGATAGGTTATATAACAAAGGAAAGCTTGGGTGCATTCCTTATTGCTCGTGATGGTAACGAGTTTGAGTTGAAGGCACAAGGTTGGCCTAAAAACGAGAAATAGCCAACTTGTTAAAGGATGTAAATAGAAACATTTTTTTTTTGAAAAACTTGGAGGAATAAAATAAAAGTACTACCTTTGCATCGCAATTGAGAAAACAACACAAACGTTACAAAAATTGATTGCAAATAACGATGGTGCCATAGCTCAGTTGGTAGAGCAAAGGACTGAAAATCCTTGTGTCCCCGGTTCGATTCCTGGTGGTACCACTCCTCCTTTCATCAGGGCGGTTCTCGCAAGAGGCCGCTCTTTTTTTTACTCATTATAACGGGGCAGTCCTAAAACCGGGACAGTAGATATTTAGTGGGGATAGGCATATATTTTGGCAAGCCTAAAAAGAAAGAAACTTTTATCTACAACTCCTCTTAAGTTAGCCCTAAATAGTTTTATTTTTGCATTGAAGGATTCGGCAGCAGCGTTTGTAGATCTGTTAATATAAAAGTTAAGTATGTCTTCGTAATGCTCGTAGAAAGTTGCAGCAATGACATTAAAGGAATGAAAGCCAGCTTCTGCGACGTTATTATACCATTTTGCCAATGATAGTCTGGCTGCATTTTTGATAGTATTCTTAGCAAAAATCATTCTTAGCGAATGTGATAAACCGTAAGCCTTCTTAATGTCAGGATATTCTCTGAACAGTATTTTGGCTCTTAGCTTCTGTTCATCAGTCCATTTCTCTGATGATTTGAACAACAGGTACCTACTTCTTACCAGCAGTTCACTACGTGTATCTCCATTTTCAAAAGTCAGTGGTTGATACGCTATCTTTTCTAACTTCGCATTCTCTTTCTCGTCATTTGCTTGCTGTAAAGCTGCCCAGCGATACTCTATTCTCATCTGTTGCACGGCATCACTTGCAAGTTTCTGTATATGAAAGCGATCAATCACTCGTTTAGCCTTTGGAAAACAATGCCTTACAATCTTACGCATACTATCGGATAAGTCCAAGGTGACCTCTTCTACGGCTTCCCGTTTCTTTTCATCTATCTTATCCAATACCTTGCAGACATCCAAGAATTTGGTTCCAGCAACAATGGCTACAAGACATCCTTGCTTGCCGTGTTTGTCCCTATTAGTGATAATCGTATAGAGTTCACCATTGGACAAGGATGTCTCGTCTATTGCTATGTTCTTACCAATATTATCCTCAAAGAGAAGCCACTTCTGAGCATGAGACAACTGATCCCAAGACCTGTAACCACTTAATGTTTCCTTGTATTGTTTCTCAAAACTACGTCCATTGATATGATAGAATTCCTCAAGCGTACGGCAGGTCACTGGGGATGTCTCCATACGTTTCTTTTAAAAAAGCTCCGAACTCTTTGGAATAACGAGTGCCGGAGGCTGTAATATCTATCTGCAAGGGAAGAGAGAAACTCTTACCTGTACGAATATCTATCCAGCGACGTCGACGAAGAACCAAAATAACCTTATGGTCACGAATCGGAAAGTCCGTTACCTCGACAGCTTCCATAAAACCTTTTGATTCAAAATGAAGATCATCGGAAAGTTCTTTCTCCATCTTCTCATCAAGATAAATACGTAACAATGAAGTATCAGACTCTATCTTAACAATAGAGAAATAATGTAATACATCACTGGGTAAAACGAATTCGGCTAACTGATATAAATATTTTTCTTCCATGATACAAAGGAAAGAAAAATATATTAATTAAGAAAATTTCCCCACCTTTTTTCTACTGAGCCCCTAAAACGGGTCAGTCATAAAACCCAGTTGCAAGTCTATACTCTTAAGCACACAATTTCATAAGTATTTATTACCTTTGCATCATGAAGAATCACCAAAACGGCTCAGTAGAAATTGTCTTTATAACTTGACGTAGCCCGCTACGTCTGCACCAAAAACAAACAAGATGCTCGATAATAAAACACAATATGTTTAGGCTCTAATGAACTATTTGGGTTAAAAAGAAAAAGCGATGACCTTCACAGGTGATCGCTTTCTTTACTCAATAGGTATTAGTCTTTTAAAGGTAAAAGATTGTTTTCAGGATAACAGTCACAAAGATATATTATTTTCGCGTCACATGCAAACTTTTAGTAGATTATTTTTTCATTATAATGATGTGTGCGAACACATGTTTTATACAAAATCTATTTTTTACGAAATAAGTCTCAAACCTCTTGTTTCATAAGGTTTTTTGTTATTTAAAAGTTCAGAAATTTAAGTTATTCCACTTGTATATTAATAGCCTTTTGTAATGCTATATGAATAGTTGTGCGTCTATACTTTATCATAACACTACCGATCCTTTTGTATAATAATTTATCCATTAAAATGCTTTTGTTATCCATAGTGTCTCCTTTATTCATAGATTATAATTAACTTTGCAAAGAATTTATGTATAAGTTAAATATTAAGTAAAAGCAAAACCTTCCATTACTACATTTATAAATGATTATGAAGAAAAGAACAATCGTGTTGTTTGGAATGCTCCTTATGGTTTTGACTGCTGTTGCTGGCGGCAAAATCAAGGTAGCATGTGTAGGAAATAGTGTGACATGGGGAATGACAATTATCGATAGAGAAAAGAATTGTTATCCAGCACAACTACAGAAGATGTTAGGAGATAAATATGAAGTCAGAAACTTCGGACACTCTGGAACTACACTACTACAACATGGACATCGTCCCTATGTCGACCAACAAGAGTACCAAGACGCTTTGAACTTCAAAGCAGACCTTGTCATTATCCACCTTGGACTCAATGATACCGACCCACGAAACTGGCCTGAGTACAGTGAAGAATTTAATGCTGATTACATCCGTCTGATTGATAGTTTCCGTCAGGCGAATCCTAAAGCAAAGATTTGGATTTGTCTTATGACCCCTATCTTTGAGCGTCATCCACGTTTTGAGAGTGGTACACGCGACTGGCATGCGCAGATTCAGAAACATATACGACAAGTGGCGACTGCGACACGAGTTCCACTCATTGACTTAAATACACCTCTATATAGTCGTCCCGATCTTCTTGCCGATGCTATTCACCCGAATGCTGAGGGCGCAAAGATTATTGCAGAGACGGTCTATGGAGCCTTGACAGGCAACTATGGTGGGCTTGCCCTGTCTCCATTGTATACCGATGGTATGGTTATTCAGCGCAACAAACCTATTGTTTTCCGTGGAAAAGCAAATGCAGGTGAAACTGTTAAGGTCAACTTCAATGGGCATATGCTTTCAGCTATAACAAATGATGCAGGAAAATGGAAGATTACCTTCCCTGCTGAGAAAGCTGGCGGACCTTATAAAGCCCAAATAAGTACGAAGAAAGAAAAGCTTACTATTAAAGACATATACGTTGGTGAAGTGTGGCTTTGCTCAGGACAATCAAACATGGAGTTACCTGTAAATGCTGTACAGAGCAGGACACAAGACTTGAATGAGGCTGACAGTCAGACACACTTACATCTTTTTAATATGTCAGCTATCTACCCAACGACTGCCATAGCATGGTCTGCTAATGCTTGCGACTCTGTCAATCGTCATCAGTACCTCCATATTGGACCATGGCGTAACTGCTCTCGAGAATCTTTGGGTGGCTTCTCAGCTGTAGCTTATCACTTTGGAAAGAAGTTAGCAGACAGTTTGCAGGTCCCAGTAGGTGTCATCTGTAATGCTGTTGGTGGTACCACTACAGAGTCATGGATTGACCGCCATACGTTAGAACAACGTATGCCAGCTATTCTTCGTGATTGGTATCATGGAGATTTCGGTATGAAATGGGCACGTGAGCGAGCATTGCAAAACATCAGCGTAAGTAAGAACCCACTGCAACGTCATCCTTATGCACCAGCCTATATGTTCGAGACAGGTATGCTTCCACTAAAAGGATATAGTATCAAGGGAATTGTTTGGTACCAAGGTGAGTCCAATGCACATAACATGGAACTACACGAACGTCTCTTCCCGATGTTACAGAAGAGTTGGCGTAATTTCTTCCATGACCCAGAGCTACCATTTTATTTCGTACAGCTCTCCAGCCTGAATCGTCCTTCATGGCCACGTTTCCGTGATTCTCAGCGTCGTATGGCATCAAGACTACGTAATACATGGATGGCTGTTACAACAGATGTGGGTGATTCCTTAGATGTACATTACACTAACAAAAAACCTGTCGGTGAGCGACTTGGCTTACAGGCTTTACACCATAGTTATGACTACAACATAGAATCTGATGGCCCTATCTGTCATTCTGTATCAGCAAAAGACAATGGAATTGAATTACAGTTTATTCACGCAAAGTCACTATCAGCTAAGGGCAGCCGCCTTATTGGCTTTGAGGTAGCAGGTGCAGATGGCATCTATTATCCAGCAGAAGCACAAATAACATCATCTAACACAATTCTTGTTAAGTCGTCTTCTGTAACACGTCCACTCTATGTTCGTTATGGATGGCAACCTTTTACACGTGCCAACCTTGTGAATGAGGTAGGATTACCATGTAGTACATTCCAATGGGCAGTAAAGAAATAAAGGTGTTTATAACCATCGTTCTTTGTTTAGAAAAATGATACAATTAAGTCAGACTGCCCACAGTCTGACTTTTTTTTATTAAGACCATTCCAGACAGAATCCTATTTACTATATTACACAAATAGATTTTCTCCCTTTATGCCCCTTGATGTATCCCTATATATTTGGTAGTTTAACCATATCATGCATCTACTATAGGACACTCTCAATAACTTTATAGCAAAAGATTTTAAGAACTTCATCATATTTATGTGGTGATTAGCAACTTTCTTTTTAACTTTGTACTCTATCTAAAAACCCCTATCAATGATTGATACAACAATGAATAACTATACCTTATATAATTCAAAGCACTCTTCTACCCTATTGATTACAACTTCAATAGCTGCTCTCGGCATTTCCTTCCCAGCCAAAGCACAACAAGTAAATACACAACCCAATATTATCTTGTTCATGGTAGACGACATGGGATGGCAAGACACATCTCTTCCCTTTGCCGATTCGATTACTGCCAATAATCGGAAATACGATACACCTAACATGGAAAGACTTGCTTCCGAGGGGATGATGTTTACAGATGCTTATGCAACTCCTATCAGTTCGCCCTCCAGATGTAGTCTGATGACAGGTATGAATATGGCTCGTCATCGGGTAACGAATTGGACTTTACATCGCGATAAGATGACAGATGGGAAACGAGATGGCGTAACATTACCTGATTGGAATTATAATGGTATTGCGCAAAGCGGTAATGTCGCACATACTACAAAGGCTATATCCTTTGTACAACTCCTAAAAAATGTAGGCTATCATACCATACATTGCGGAAAAGCACACTGGGGAGCTATTGACACTCCGGGTGAGAATCCGTGCCATTTTGGCTTTGACGTAAACATTACAGGTACGGCAGCTGGTGGATTAGCTACCTATTTAAGCGAACGTAACTATGGTTTTGCAAAAGATGGCAAACCCACATCTCCATTCGCTATCCCAGGCTTGGAACGTTATTGGGGTACTGGTATCTTTGCCACAGAAGCCCTTACACAAGAGGCAATAGCATCATTAGAGAAGGCTAAGAAATACGACCAACCTTTCTATCTCTATATGTCTCATTACGCTGTGCACGTACCAATCGATCGAGATATGCGTTTTTACCCTACGTATCGTGCACGTGGTCTTTCGGAAAAGGAAGCTGCTTACGCTTCATTGATTGCAGGAATGGATAAAAGTTTGGGAGACCTCATGGATTGGGTCGCAAAGGCAGGACTTAAGCGAGAGACCATCATCATCTTTATGAGCGATAATGGAGGACTCGCCTCATCATCCTATTGGCGGGATGGAGAACTTTACACGCAGAATGCACCACTCAAGAGTGGTAAAGGTTCTCTGTATGAAGGAGGTATAAGAGTTCCCTTTATTGTAAAATGGAATAATATTGTAAAACCAAATACTCGCTCTCATGCACCTATCATCATAGAGGACCTCTACCCTACCTTACTCTCCATGGCTGGAATTAAGAACTATCATGTACCACAAAAAATAGACGGACAAGACATTACACCTATTCTTCGTGGTAAACAACAAGGTGATAAGAAGCGACAACTGATATGGAACTATCCTAACATTTGGGATGGAGAGGGATTGGGAATCAGTCTTAATTGTGCCATTCGTGAAGGGCAATGGAAATTGATTTATTCGTATCTCACTGGTCAAAAAGAACTATACGATCTATCCAGCGACCTGTCTGAGAAGAATAATCTTGCTTCTTCTCACCCTCAACTCGTTGAACGCCTTTACAGACATCTCACATCTAAATTACATAAAATGAATGCACAGAAACCAATCGTAGAGGGTGAAAAAAGAAAATAAGAGTGGTTAGTTTAAGTAGACATAAGTTATTCATTGATTTTATTTCAACTGCATCATTCTACTCTTATAGGATAAAAGAGAGAATAGTATCTCCTTGAAGTGATATCTTATCAACTTTACGAAATAAGCTACTGACCCAACAGACTAAGTAAGTTCTTTGTAGTACAACTTGTTTATAACAATAAGTTGAACCTACTTTGGTGACATTTTGCGAGATATTTAGCAGGCAGCACCATTGGTGTTTACCAACAACACAACACGTGCGGAGCATCAACACGCTATGTGCGGAATAACAATACATCAGCTGAAGATTGTCAAAGAATCTCGTTTTGGTTATTATAAAGAAAACTGTAAAGTGCTTTATAAAGAACTAATATAGGACAACTCTACCAAACAGCACTATAAAAACGTCTTATTGATATAACGCTTTATCATAGTCAATAGTCTTCAAAACAAGACGACGACGATTGCTGTTGAAACTTGGAGAGATGACATTCCTCTCTTCGAAGTAGTCTTTTATCTTTATTCCAGCCAGATAAAGCAACAGATGTGGTAGATCATCTGTCATAAACTTATTACTTCTTGCCATCAATGTTTCCGTAATAATCTTGCGATGTCTCTGCTTATATATAGGCGAACACCATATCCAAAAAGGTATTTCAAACTCTTCGTGATACTTCCTGAGATTGATTTGTTCGACTTCAGTTAACCTACCAGCCATATTTACATCTTTACCATAGCAATCCTCTCCATGGTCAGACAAGTAGACAATAATGGCATCCTTGTTACGGAACTGTTCTACTATCTTGTTCAATACATAATCATTATAAAGCGTTGCATTATCGTAGTCTGCAATAGTTTGTTTCTCTTTATCTGTCAAGTCCATACGCTTATAATCCATTATTCCAAACTTCTTCATATTACTTTTACAACGCAATGAGTATTGAAAATGCTGTCCTAAAAGATGAAAGATTATCAGTTGTGGCTTCTTATAGCTAATGATATCTTTATAATCATTTAATAGGTCCTCATCATAGTTATGAATCGTAACATTTCTATAATCAAACATTTGCTTGTTTAATTGTGGATGATTTAAGAAGAAACCACCTACAAGATTATTCGTCCAATCAGGTGTATAGTTAATACCATACGGAAATTGATTAGACAAGAAACTAACATGATACCCCGCTTTCTTAAACACTGCTGGAAAGAGTACATACTTACTCCAATCACCTTTCTCATCAACGGATTGCAATGAGAATATTTGCTTGAACACTTTACTCGTTAGATTCCATGGTGAAACAACATTAGTAAACACTGCTAACGAATCTTTACCATTCATCATGGCAAGTTGATAAGGCGTTGTTGGCAAGGGATAGCCATACAGTTGAGAATGATGTCGGTTGGCACTTTCACCTATAACAAGTACAATTGTAGGAGATGTGAAAGAACATGAATCTACTTTAATTTGCTGATTAGCCATAATGACTCCATCAACCTGCTTTGCTATCAAGTGGTTTGAATAAAGTCCATAAACAATACGTTCGACTGGATGATAAAGATGTGCAAAACCATTAGTAACCGCAACCTCAAGTTCTGAGAGATTCTTAACTCTATAAAGCTGAACCTTATCATAAACACTTAAAGCTATTCCTACAAAGATTGTAAACATTAAAGCAAAGGCAACAAAAGGTTGCTTGAGATAAGAGGTTGGAAATGTCATCTTCTTTACCGCCATAACAATATGACAGAGTGCAAGAAAAAGAATAATATCAGCTGCGGAAAAGAAAAGTTTTAGATTAAGATATTGCAAGAAAAACTCTGTAGCCTCTCTGCCTGTAGTTTCTTGCGCTAAAAGAAGCATTGTCGGTGTAATTGGAGTATCAAAGAGTGTCTTACAACAAGTATCTATTATGGCTACCACATAAACAACACTACTCAACATAATCACCAACCCTTGACGTATTGTTTGTTGACAAAGACTCAGTAAAAAACAAATAATATATAGATCCGCAATCAATTCTATATAACCAAAAACATTACGATGACTCACATTCGTAAAGGCACCAACCAACAGCATAAACATAAAGAAAAGAGAATTCTCTTCTATTGGCTTTACCATCTTAGTTACAAAGGTACTTTTCATTTTCGTATTATTGATTTGCTTCATACTGTTTCATCCAATCATGATCTTAACATGCTATAATAATCAGGATTAGTTACAAAGGTACAAAATAGCATCCGTATTTTCAAATAATTGTTATTTACATAAGCGTTATAAATATATACATTATACCATAATTCTATATTGATCGTCTATTTATGTAACTTAACATAGCTCGCTATACCTTTAACCCAAAGATAGATAAGCTGCTCAATTATAAAACAAAAGCAGTTTAGGCTTTAACAGGCAGTTTAGCTTAAAAGGATAATTATAACTACTAAGCCTAATCATAAGAACGGTGAGCACATACCAACATGTAGCTCACCGCTCAAAATAGTTGTTTATTCTTCAATTGATTGGTTTCAACATAATAAGAAGAAACATCAAAAGAAAATAACGATAGAAGTTGGCAAATGGCTTAAGAATTATTTTCTTTTCTGTTTGCCAAGAAGTTCTTATATATTTTCTTTACCTGAGGTGCAAGGAAAATAATACCAATAAGGTTAGGAATTACCATCAGACCATTGAAGGTATCTGCCAATTCCCATACCATATCTGCTGCAAAAAGACAGCCAAGAAAGACAAAGAGAACAACAAGTGCACGATAAGAAAGAATACCCTTCTTACCAAACATAAACTTGATATTCATCTCAGCAAACATATACCACCCAATAATTGTTGTGAAAGCAAAGAAGATTAGACTGATGGCAAGAAAGATAATTCCACCATTTCCAAAAGCTATCTCGAAACCTTCTTGCGTAATAGCAACCGATTTTAAGCTTAGATTTTGGAAAGAACCTGTCAGCATAATGACAAAAGCTGTTGATGTACAGATAAGAACGGTATCAACAAAAACACCTGCCATAGCTACAAATCCCTGCTCAGAAGGGTCTTTAACATCAGCCAAAGCGTGAGCATGAGGTGTTGAACCCATACCAGCCTCATTCGAAAACAGACCACGAGCAACACCATAGCGAATGGCATATTTCATCACCGTACCAGCGGCTCCACCTGCTGCTGACTTCATAGAGAAAGCATCTTGGAAGATTGTACGGATAACATGAGGCAACTGATCAGCAAACATATAAATGATAACAAGCGAACCCAAGATATATACAACCGCCATGAAAGGGACTAAAAGTTCGGCTATAGCGGTGATTCGGCGTTGTCCTCCAATAATTACTACACCCACAACTGCTGCTAAAACAATACCTATAATATAAGAAGGTATATGGAAAGCATTATTCAAAGCTATTGAGATAGAGTTTGCTTGTACCATATTTCCAACGAATCCCAACGCAAGAACAATAGCAACAGAAAAACAAACAGCAAGCCACTTACTACCAAGTCCATAATAAAGATAATAGGCTGAGCCTCCGACCGTCTCGCCATGATACTCTTTCTTATACTTCTGGGCAAGTACTGCCTCAGAGAAAATGGTGCTCATTCCTAACAATGCAGATACCCACATCCAGAAAATAGCTCCCATACCACCACTTGCAATAGCTGTTGCCACACCACCAATATTACCAGTACCAACTTGAGCGGCTACAGCTGTGGCTAATGCTTGGAATGAATTAACTTTTGTTTCACCAGGCTTTCGCTTCTTGAATATTGGACCAAAAGCATACTTAAACGCCAAATTTAGATGGCGAATCTGTGGGAAACCAAGGTAGACAGTATAGAAAATGCCTACTCCTAACAATGCGTACATGAGAAAACTATTCCACAAAAACTCATTGAACGCTTTTACATAGTCTAATACATTCATCGGCTACATAGTTTAGATATTAGTAATAGATTAGTGGATAATACCACATTAGATTGTTTAGTAACAGATTAAATAATCAATCTTACGCCGCAAATATAGTATTTTATCTTTTACAAAGCAACGATAAAAGCAACTTTTTGAGTTAATCACAAAATTACTTTTGTATTAACATTTTCATCATGCAGAGTTCAATCTGCTGCTATTTTATGATCCAATTAACGGTGTAATTATCATTCATAAACTCATTTATATCTCTCATCTGCCTACATTGAAAATCTCATCATGAAATACTTCAACTATACATACCGCATTGAAAAGACTTTACATAAATCTAAATGAACCTATTAAAATAAAGACAAAAAACACACATAAATATCATCTTTCTAACCAACAGGGAATCAACCACTTAAGTTAAGTCATTTCAAAAGATGCTTAATAGGCTTCTTAAAGGGCGTTAGTAAGGCCTCAAAAGGGCGTCTTTTGAAAGCCTATTGGACGTTAATTGAATGCTAAAAGAGCATATATTAATAACGAGATAACTCAAAATATTTTACAAATATAAAATAAACAGAAAATAAACTACTCTAACTAAGATTGTATCGGATGATATGTTAGTTTAACCCAAATCAGTCATTGGAGCCTAAACATATTTTGTGTTTCTTATCGAGCAGATTGCCTGTCGTTATAACGCAGGCGTAGCGGGCTACGTCAAGTTACAAAGACACACAAGATACCGATAAGAAAATAAAAGATGTTTAGAAACAACACTATAGTAATAAGAATTATACATAACCGATTTGGGGTTAACTCTTATCCTGCTGAAAATCATCATGTCTAACACTAAAAGATTTCATCAAATAGCCATGTATTAATAAAAAGGCACAAGAAAAGTTATAAATAATTTGGAATTATCAGAAATTCTTGTTACCTTTGCACTCGCTTTATAAAAGCATAGGGAGATTCGCTAGCTCAGCTGGTAGAGCACAACACTTTTAATGTTGGGGTCATGGGTTCGAGCCCCATGCGAATCACTTGAAACAACAAGAGGAATATCCGCAAGGATATTCCTCTTTTGTCTTAGTATCTGTGTGCTATAATCCCCCCAATGATAGACATCAGGGCTCAGTAGAAAAAAGGTGGGGAAATTTTCTTAATTAATATATTTTTCTTTCCTTTGTATTATGGAAGATACTTATCTATATCATTTAGCATCGTTGGTTCTCCCTAAGGATGTATTGAAATACTTCTCTGTAGTTAAAATAGAACCTAGTCCTTCATTATTGCGTATCCATCTTGACGAGAAGATGGAGAAAGAACTTTCCGATGATCTTCATTTTGAATCAAAAGGCTTTATGGAAGCTGTCGAGGTGACGGACTTTCCGATTCGTGACCATAAGGTTATTTTGGTTCTTCGTCGACGTCGCTGGATAGATATTCGTACAGGTAAGAGTTTCTCTCTTCCCTTGCAGATAGATATTACAGCCTCCGGCACTCGTTATTCCAAAGAGTTCGGAGCTTTTTTAAAAGAAACGTATGGAGACATCCCCAGTGACCTGCCGTACGCTTGAGGAATTCTATCATATCAATGGACGTAGTTTTGAGAAACAATACAAGGAAACACTAAGTGGTTACAGGTCCTGGGATCAGTTGTCTCATGCTCAGAAGTGGCTTCTCTTTGAGGATAATATTGGTAAGAATATAGCAATAGACGAGACATCCTTGTCCAATGGTGAACTCTATACGATTATCACTAATAGGGACAAACACGGCAAGCAAGGATGTCTTGTAGCCATTGTTGCTGGAACCAAATCCTTGGATGTCTGCAAGGTATTGGATAAGATAGATGAAAAGAAACGGGAAGCCGTAGAAGAGGTCACCTTGGACTTATCCGATAGTATGCGTAAGATTGTAAGGCATTGTTTTCCAAAAGCTAAACGAGTGATTGATCGCTTTCATATACAGAAACTTGCAAGTGATGCCGTGCAACAGATGAGAATAGAGTATCGCTGGGCAGCTTTACAGCAAGCAAATGACGAGAAAGAGAATGCAAAGTTAGAAAAGATAGCGTATCAACCACTGACTTTTGAAAATGGAGATACACGTAGTGAACTGCTGGTAAGAAGTAGGTACCTGTTGTTCAAATCATCAGAGAAATGGACTGATGAACAGAAGCTAAGAGCCAAAATACTGTTCAGAGAATATCCTGACATTAAGAAGGCTTACGGTTTATCACATTCGCTAAGAATGATTTTTGCTAAGAATACTATCAAAGATGCAGCCAGACTATCATTGGCAAAATGGTATAATAACGTCGCAGAAGCTGGCTTTCATTCCTTTAATGTCATTGCTGCAACTTTCTACGAGCATTACGAAGACATACTTAACTTTTATATTAACAGATCTACAAACGCTGCTGCGGAATCCTTCAATGCAAAAATAAAACTATTTAGGGCTAACTTAAGAGGAGTTGTAGATAAAAGTTTCTTTCTTTTTAGGCTTGCCAAAATATATGCCTATCCCCACTAAATATCTACTGTCCCGACATCAGCAGTAATAATCGAAGCTACCTTACAATATTTAGTTGGGGTGTATGCCGCTTGTCATTAGAAAACTACAATAAAAAAGTAGGCTTCAAACTTTGATTTATAAAATTAGTTTTTTATATTTGCAGAAACTAATAATTTAAAATACAAACAAATAGAACAATAACCTTTTAGACTGGCAGGACGTAAACTCTCTGTCACCTATAAAACCTCGAAGACTAACCTCTTTATACCTATGGGCAGCATCGTTCCGCCTCAATCTACTAATGTGGCTTTAACGTTGAAAACCGATTACTGTGGAAATATGATTTATGAGAATGGACAATTAAGCAAGATTCTTACCGACATGGGATACATCACACTTGCAAATTCCACTCCAACATACCATTACTACTTGTAGGACCACCTTGGAAACAACCGTGTAGTGATAGATGAGCATGGAAAAGTGGAGCAAGTGAATCATTACTATGCCTTTGGTGGACTGATGAGTGAGAGTACAGGCGGAGGCGCACAGCCTTACAAGTACAACGGCAAGGAACTTGACTGTATGCACGGATTGGATTGGTATGATTATGGTGCACGCCACTATGATGCTGTGCTGGGAAGATGGATGTGTGTGTGGATCCGTTGGCAGAAAATCAACTTGGGAGCAAATAACATTTTATGTAGAAACTATAAAGCAATCAACAACCATAAAGGGACTTGAAAATTAGGGTTTAAGCTTTAGTGAAGCTATGGGAGCAGAAGGTGTTCATGAATCTGTGCATGCAGCTGACCCTGTAGAGGTTAATCGAGATATACGTTCCAGTCAGCCAGGTCAGAAAAAGCTTTCAGAATTTATTTATGAAAGGAAGGCAAGGCTAATGGAAGCTAAGTTTAGAGAAGAACTAAAGAAAAATAAAGACAATCAAAATGAGAAAAGAAAATTATAAGATAAAGCACAAATACCTATTGGGGATATTTATCATTAGTATGTTAATATTCTCAGGACCTTTATACTCTCAGAATAATATTATTCCGAGTAATTTAAGAAAGAGTTTATATAAGCTGTATCATTATAATACAACTTGGAAATCAACTATCTCAAAATTAAGTTGTGTTGAAGGAAAAAAACATGATGGTGTGTACACTTTTCGATTAAATTATCAACCCCATTACCCAACGAGAGTTTTCTTTATAAGTAATAATACACCTTATACAATAGAAAGCTTAGGCTTCGAGAATACAACAGGTGTATTACTTGAAGCTTGTCATTTTCTATCTTCAAAACATCAAACTAACAGTTATATAAAGTCCATTTTATCTGGTGTCTACAAGTATTTATTTGCAGAATACGGATTAACTTATGGTAGTGATTTCTTCGATAAGAAACCTGACTTCTCTAATGAAAGAGATAAGATGAGGTTTATTATTCATAGGGTTAACAATGTTGATAAACTTAGAAAACAAGCATTATATCTGAGAACTGACAGAAAAATCATTCCAGATAGTATTACGAATTATATTAAAGGTAATAATTTAAATGATGAAGAAGCCTTATTATTTTTGCGTTATATTATTTTGAATAATTGATTGTTACCAAAGTAATATTAGGAGAAATTCCCTAAGCTAACGAAGCTCCAATAAGCAGTGTTAATCAAAACTACCTTACAATATTTAACTGGGGTGTATATAGCTTGTTATTAGGAAATCGCAATAAATAGTAAGCTTCAAACTTTGATTTCTAAAATTAGTTTTTTATATTTGCAGAAACTAATAATTTAAAATACAAACAAATAGAATAATTACTCTTTGGACAGATAGGGCGTAAACTCTCTGTCACCTATAGAACCTCGAAGATTAACCTCTTTGTACCTATGGGCAGCATCGTTCCGCCTCTATCTACTAATGTCGCTTTAACATTGAAAACCGATTACTGTGGAAATATGATTTATGAGAATGGACAATTAAGCAGGATTCTTACCAACGTAAGATACTGGAAAGTCGAAAGTTTTTTGTTTTACTGATTATAAATAAGATTTTTTGTTATGTGCGAGTATCTAAACAAAAATGATTTAAACTCATTTGATTGTTATATAGGTCTTGGGATATCAAAGGGCTTATCTGTAGGAAACTTGGGACTTTTATATGGGACAAGTGCTGTACAGGGTGAAAATGGATATAATAAAACTGATTTTTCAAGGTCGTATGGAGTGAGTCTAAATGCCAATCCAGCAAGGTTTGATATGTCAAAAGGAGGAGGACGCACATGGATACCATTTTTTTAAGAAGACGTATTTTATGGCCAATGTTCTGTGTTATTCTCTTTTTTATTTTTATTAAACAAGATGATCTGAGTAATAACTCTTATAATCAATACGTTAAAGGGCAATCATATTGTGTGAAAGTCTTGAGCATAAAGAAAGAAGCACGCGAATATTATGTTTATGGTATCGATAGAAAGGGACAGATTCTTAAATTAGATATTTCTTCAAAGTGGGATCTACATACAGTTCAGGTAGGAGATAGTTTAATAAAAAAAAGAAATAGTTTTGACATAAAACTCGTATCGAAGCATAAATCAAGAATCCTAATCCCTGAACTTCCTCTATAATTATTGGCTTACGAGCAATAAGGAAGGGAATGAAAGCGTTATTGTTGACAGGATAGGTTACAATAAGAATGGTCAAACAATCTACATAAATCTTGACAATGATACGGAAACTATCCATACCTACGACAAGCAGCGTAAGCGTCTGTTATCAATGAACCTTACGTTAGACGGTCTATGCGAATCCTATTAGAATCTTAGATTTCATGGGATTGATTCCAATGAGGAAAGAAGCTAAACGTTATAGGGTGGAACACAATATAAATGATCGAGTACTTAACTGGTAATAAGATAGAATCAGATGATTATAAATTATATATTTTTTAGGATACATATGGCTTATAAAGCAAAACATGATTCTGCTATGTTAAATAGTATTTTGTATTTATCATGCGTACTTATGTTTGTTCTTCTTCCGATAGCAGGTGTCGTACTCGAGATAGCACGGAAAGGTGGTAGAATTAATACCGCGTTTTTTATTTTATATTTCATTTCAATCTTAGGTTTTGTTACAATGAAATATGGAAATAAGAAGATGGTAGAGCGTTTGTATAAGAAATATTCCCAGCATAAATTTAATAGGATAATCCCAACTTATTGCTTCTTCTTCATACTACCGATATGCATTATATTGGGAATGTCTATCTATATCATAATATTAAAAAACTTTGTTGACATTGACAAAATAAGAGATATTATATACAACATTCTAACAAGCTCATATTAAAATTGACGTATAATTGCCTTAAATATCCTTACTGCCAAACATCTATACACGCTACGGATCGACATATCTTTACAATTCAAAATACAAAAGAGAACTACACACCTTTTCTATTGTGCTTTCACTCCTATCACCTCTTTTCTCCAACTAAGCATCTAACAATAAACAATTTACGCAGAATGTTAAAAATGACAGCAATTAAAATTAGATTAGGTTTTTCATAGTAATTCCATATGTAACATTTGGAAAATAACACATAACGTACCAGCCTATTTTCTTATTGCTTAAAAGTATATTTACGAAATAAAGTTGTATATTTGCCCTTGAAAAATAATATCTTTAAGCATAAATAAGTAATGGGGTTTACACTATTTGGAAATCAGACAAGCGTATCTTCTAAATATAAGAACTCTCTGCCGACTTTTACGAAAATAGGAGTTGTCATTGTAAGTGTGGAAGATATTAGGACTTATGTCCATGGTGCTACTTACGAAAGCTGGACCGTATACGAATAATGAGTAAAAACAAAATAAGATGTTTAGTCTTTTTAATAAAAATAAAATAGAGGAGCAGGATTTCTACTTTCTTAAAAATGTAATTTGTATCTTGCCAACTAAATGGGACTTTTTAATAAAGCAAATAAATAGCAGATTCATTATAGGAAAATGTAAAAATACACTTTATGGGAAGGGATTCTACAACTTGGTTCTCAATAGAGAATACTATGACTATAGTAATTATAAATATCCAGAATTAGTAACATTATCAGGTATTTATATTTGGAACAAGAAAAAACGAGAATATGTAGAAGTACAACTATATATTTCGTTTGGTACAATAATTGGCTATTATTTTAATTCTAAATATAACCATTTAGATTGGCATAAAGTTTCTCTTAATACACTGAAAGAAAATAATTATGCAAATCATTCAAACGGAAAGAAAGACATCATACAAATGCTTTCGCAAAAACTTTCGCCAGAAGAACTAAAGAAAATAGATATAGGTGATATTAATGAACTTCAGTTCGAAGGAAATACATATTATACGATTAAGAATTTAAATGATGGAGATTATATGGCTATTAATAATACAGGCGAAGTCTTCATTATAACTCATGCTCCTTTTGAAGTAAAGAAACTATACTCTTCTATTAGGGCTTTTTTGCATCAAACGCTATAACTTTTATTCTGTGCAGGAAATATCATGTCACTTTTATCTATCTTTAAAAAATAGAACTGTCTAAAAGGAATATATATTATTGAGACAATTAAAAAAATAAAAGGAAGACGCTATAAATGTCTTCCTTTTATTTTATAATATCTTGATAAAAAGCTTATTACATCATACCACCCATACCTGGAGCAGCTGGCATAGCTGGAGTATCCTCAACCTTGTCTACAATAAGACACTCAGTTGTCAGGAACATACCTGCAATTGAAGCTGCATTCTCAAGTGCAACACGAGAAACCTTAGCTGGGTCGATAACACCTGCAGCACGAAGGTCCTCATAAACATCCTTGCGAGCATTGTAACCATAGTCACCCTTACCCTCACGAACTTTATTTACTACAACAGCACCTTCACCACCTGCATTAGCGATAATCTGACGGAGAGGCTCCTCAATAGCACGACAAACAATATTGATACCTGTCTGCTCGTCAGCATTCTCACCCTTAAGGTCCTTCAATGCTTCTTGAGCACGGATGTAAGTGGTACCACCACCAACAACTACACCCTCTTCCATTGCAGCACGAGTAGCGCAAAGAGCATCGTCAACACGGTCCTTCTTCTCCTTCATCTCTACCTCAGAGTTAGCACCAACATAGAGAACAGCTACACCACCAGAGAGCTTAGCCAAGCGCTCCTGCAACTTCTCCTTATCGTATGAGCTTGTTGAAGCTGCAATCTCGTTCTTAATTTGAGCCACACGGTCCTTGATTGCTTCCTTCTCACCAGCACCATCAACGATTGTTGTATTGTCCTTAGAAATGGTAACCTTCTTAGCTGTACCCAACATCTCAAGAGTTGCCTTATCAAGTGAAAGACCCTTCTCCTCGCTGATTACCACACCACCTGTCAACACAGCGATATCCTCAAGCATTGCTTTGCGACGGTCGCCAAAGCCTGGAGCCTTAACAGCACAAATCTTCAAACCTGCACGAAGACGGTTTACAACCAATGTTGTCAATGCCTCTGAGTCAACATCCTCTGCAATGACCAATAATGGACGACCACTCTCAGCAGCTGGCTGTAGGATTGGAAGGAAGTCCTTAACGTTTGAAATCTTCTTATCGTAGATGAGGATATATGGGTTCTCCATATCACACTCCATCTTATCTGTATCTGTTACGAAGTAACCAGAGAGGTAACCACGATCAAACTGCATACCCTCAACAACACCGATACTTGTCTCACGAGTCTTGCTCTCTTCAATAGTGATAACACCATCCTTAGATACCTTACGCATAGCATCTGCAAGCAACTTACCTATTTCAGGATCGTTGTTAGCACTTACAGTAGCTACCTGCTCTATCTTGTCATAGTTGTCACCAACTACCTCTGCAGAAGCCTTAATATGATCAACAACCTTAGCTACAGCCTTGTCGATACCACGCTTAAGGTCCATTGGGTTTGCACCTGCTGTAACATTCTTCAATCCTTCAGTAACAATTGCCTGTGTGAGGATAGTAGCAGTTGTTGTACCGTCACCAGCATCATCACCAGTCTTGCTTGCTACACTCTTAACAAGCTGTGCACCTGCATTCTCAAAGTTATCCTCAAGCTCTACCTCCTTAGCAACGGTAACACCGTCCTTAGTAATCTGTGGAGCACCAAACTTCTTACCGATAACAACATTACGCCCCTTAGGACCGAGTGTTACCTTCACTGCATTTGCCAACTGATCAACACCACTCTTCAAGAGTTCACGTGCGTCTGAATTGAATTTTATCTCTTTTGCCATTTTCTTTATTCCTTATTTTGATTGTTTATTTATGCGTTGTTTGCTATTCTTTTTTATCTCTTATATGTATAACATCATTCTACAAGATATAACAGAATAGCCAAACTACAGCTATTTTAAGACCTTTTTATAAAGAGAGAATAGGAGAAGTGTTACTCAACAACTGCCAACACGTCGCTCTGACGCATCATCAAATACTTCTCACCCTCATTCTCAAGTTCAGTACCAGCGTACTTACCATAGAGAACCTCATCGCCAACCTTGAGAATCATCTCCTCATCCTTAGTACCATTACCAACGGCAACAACTTTACCACGCTGTGGTTTTTCCTTGGCTGTGTCTGGGATGATAATACCACCAACTTTCTCTTCTGCCTGTGCTGGAAGCACGAGGACTCTGTCTGCTAAAGGTTTAATTGTCATAATTGTATATGTTTTAAGATTTTAATTTTCATTCTGTATATGACCTGTCACCAAGTCATTTCGCCTTCAATTATACGAAAACTATGCCAAAAGGACTTACTGACAATCTGTCAGTTCTTCTTACCTATTCGACTAAAAACAAAAGAAAATAATTATCTTTGCATTAGAAAAGAAGTTGATAAATTAATAAAGGGTTAACAATGAAGCAACTTACCAAGACTATAACAAATAAACTTCAAGCACTATCAGATGCGGAGAAGCGAGAGATATTCCCTAAGTTCTTTAAGGCTGGCAAAGGAGAATATGGTGAAGGCGACCGTTTCTTAGGTGTTACCGTACCCAATATCAGAGCTATTGCCAAGTTACACAAAGACATATCCATAGAGGAGATACGGGAGCTGATACAGTCAGAATGGCATGAAGTGCGCCTTTGTGCCTTAATCATAATGGTAGAGAATAGTAAGAAAAAAGACGAAGCTTTACGCAAAGAGCTATTCAATCTTTACCTTTCTCAAACTAAGCGAATCAATAACTGGGACCTTATTGACCTATCTTGTCGCTTCATCATAGGCGAATACTTACTTGACAAATCACGTGACATTCTTTATCATTTAGCTCAAAGTCCACTACTATGGGATAATCGTATCGCTATCGTATCAACATACGCATTCATTCGTAAAGGACAATTAGAAGACACCTATGCACTTAGCGACCTCATGATGCAGCACCCACACGACCTCATGCACAAAGCTATTGGTTGGATGCTTCGCGAAGCTGGGAAGCGTGATTCTGAGCGACTTTATGATTACGTGATGAGCCATCGAGCAGACATGCCCCGTACCATGCTACGTTATGCAATTGAGAAGTTCTCACCCAAAGAGCGCGCTATTCTCATGAAACGTGCCTAACACTTCCCCACTCTATTACTTCCATTTGGACGCTAATCATACGGTCAGAGAAAGAATAAAAACAACCCTTTTGTCATATTTTTTCATATAATCATTTTTAAAAGAGCACAAATTGCATTCAAATTAACGCCTAATTGACTTGCAAAAGATGCCCTTTTGAGGTCTTACTAACGCCCTTTTGAAAGCCAAGTAAGCACCTTTTAAAATCTAACCTTGTAACTAATTCATAACAAGAGAGTTACAAAAGCACTCAAAATAGTATTTTTTGGCGTAATGGACATTTGGTAGGCTGAAAACCTCTCGGAATTCTTTTATTTACTACCTTTGCAGCATTTGAAAATCTATGAATAAAAAAACTGTATCTTCTGTAATAGCTCAAATGTTAAAAAGAATGGGCATCGACGTTCTGTTCAGATGTATTCCTGCAAGGATTGTGGTAGACAATTTCAAGGTGGTCTGCGTATAAATAATATTTCTCTATGGAACGACTATCTGACGGCAAATCGAACGATATCTGATCTATCCACTCTTTATAAATGTTCAGAACGAACCATACGACGTAGGTTGAGCTTAGTAGTAGATAGCTTTACTGCTACTTACCCCAAATCTGCAGTAATAATATTGGATACAACATACTTTTCCAAGACATTTGGTGTGATGCTGTTTCAGGATGCTTCATCAGGCAAAATACTCTATCGCAAGTTTGTCAAAAACGAAACTAACAGAGATTATCTTGATGGACTTCGGTATATTACGGAGCGTGGAACTATGATAAAAGCAGTGGTGTGTGATGGGCATGTAGGACTTTTACAAGCTATAAGTTTCTGTCCCGTACAAATGTGTCAATTTCACCAATTTCAGATAGTTAGAAGACTCCTTACTAACAACCCACATTTGCCTGCAGGCGTTGAACTGTTGGCATTAATGAGAAGGATGTTCTCTATGAGAAAAGAAGAGTTTATAACCGCTTTTGATAAATGGTGTGATAAATGGAAAGAGTTCCTAAACGAACGAACTCTCCTAATCTCGGGCAAGACAACTTATACACACAGAAGGCTGAGAACGGCAAGACGTTCTATTAAGACACATCTGCCATGGATCTATACGTGTGAGGAGTATCCGGATATGCAAATACCTAATACAACAAACCTGTTGGAAGGATTTAACTCACAACTTAAAAGAGCACTACATAATCATAATGGATTGAATGAAGCTAACAAGAAGAAGTTTATAGATGGATTCATAAATACAAAAAAGTAG

Protein sequences of DBSCAN-SWA_1

>CP022040|1079793:1132954|1126333_1126678_+|ASE17403.1|DBSCAN-SWA
MDTIFLRRRILWPMFCVILFFIFIKQDDLSNNSYNQYVKGQSYCVKVLSIKKEAREYYVYGIDRKGQILKLDISSKWDLHTVQVGDSLIKKRNSFDIKLVSKHKSRILIPELPL
>CP022040|1079793:1132954|1088360_1089665_-|ASE17378.1|DBSCAN-SWA
MTKALSLFELNSLVADVIDATLSRSYWVEAELSEARENRGHCYMELIEKNEGSNVPIARASAKCWSNIWTLIKPAFIRITGQEIRAGMKVMLQVHAQFHPQYGFSWIVDDINPEYTMGDMMRKRQEIIRQLKAEGVFDLQKELCLPMFAQRIAVISSETAAGYGDFCNQLETNDYGLYFHVELFPAIMQGDSVEQSIINALNQINSREEDFDCVVIIRGGGATADLSGFDTLNLAENVANFPLPIITGIGHERDESILDMVSFQRMKTPTAAAAYLIDHIASTLMRVENAQAAIIDGVKKALEVEKMRIQHIGSHIPVLFSVVRTKQDAWLEGLSQRLVMRMNEAIKQAEFYLSTLQNCMLLTLQNKLSVEQHRLDILEQRARLLDPSLLLKRGYSITLCNGRTIRNAKDLKIGDTITTRFETGEVESKVERLS
>CP022040|1079793:1132954|1110133_1111243_+|ASE17391.1|DBSCAN-SWA
MEIKDLGEFGLINRLTKDIQPINNSTIMGVGDDAAVLHYSDKETLVSSQMFMEGVQFDLTYIDMEHLAYKVAMIAMSNIFAMNGQPRQLIVSLGLGKRFKVEDLDQFYAGLNKACAKWNVDIVGGDTTSSYTGLAINLTCIGEAAKDDIVYRSGANETDLICVTGDLGSAYMGLQILEREKTVYYQQVQEYNNKVKEAQSNKDEKRLEALRQERAAIEDFQPDFAGKEYLIDRQLKPEARGAVLSQLRTAGIHPTSMIDISDGLASELKHICEKSHCGCRIYEKNIPIDYQTAATCEEFNMNLTTAALNGGEDYELLFTVPIGDHEKIDKMENIRQIGYITKESLGAFLIARDGNEFELKAQGWPKNEK
>CP022040|1079793:1132954|1106376_1108155_+|ASE17388.1|DBSCAN-SWA
MKQFFKFVFASFFGMMLFSIVTGLFALFTIVGMIASQDTTKEPEDNSILVLNLSGQMSERSENNFLSQLQGSQINSLGLDDMLEGIRKAKDNDKIKGIYIEAGAFASDSYASMQALRKALLDFKKSRKWIIAYADTYTQGTYYLSSVADKVYLNPQGQIDWHGLASEPVFIKDLLAKFGVKMQVVKVGAYKSATEMFTGDKMSDANREQTSAYLNSIWGNITKEVGASRGLSVAQLNAYADSMITFADPQEYVKLKLVDGLVYTDQIKGIVKKQLGIEADKDINQVTIADMVNTEDKNQGDKENEVAVYYAYGDIVDGVVGGLFSQGHQIDAQVVCKDLEELAKDKDVKAVVVRVNSGGGSAYASEQIWHQIMELKKLKPVVVSMGGMAASGGYYMSAPANWIVAEPTTITGSIGIFGMFPDVSGLLREKLGLKFDEVKTNKYADFGTRARPFTEEEMSYLSQYVNRGYKLFRHRVAEGRKMTEKQVEKVAQGHVFTGQDAQKIGLVDQLGGLDVAVAKAAQLAKLPNYRKCAYPKEPNFLEQMMEQTNPNNYLSQQLRANLGDYYEPFTLLKTIDQQSAIQARLPFYPNIH
>CP022040|1079793:1132954|1086036_1086522_-|ASE17375.1|DBSCAN-SWA
MNISKKMQDAFNAQIAAEMWSSNLYLQMSCWFRKEGWKGFSSWMYKQAEEERQHAMDMAQFVLHRGGEVILTSIDAVKTSWTDAKEAFVDTFAHEQKVTELINKLADVADEEKDRASQNFIAKYIDEQVEEEKNVKDILDSFAHLESHAIAHIDSKLEQAR
>CP022040|1079793:1132954|1086987_1088004_-|ASE17376.1|DBSCAN-SWA
MKDIEWSSLSFGYMPTDYNVRCYYRNGKWGEVEVSSDEYLKLHMAATCLHYGQEAFEGLKAYRCPDGKVRVFRVEENAKRLQNTSRGIVMPEVPTELFAEMVKKVVRLNQEYIPPYESGASLYIRPLLIGTSAQVGVRPAEEYCFLIFVTPVGPYFKGGFCANPYVIVRDVDRAAPLGTGMYKVGGNYAASLRANRRAHEQGYASEFYLDAKEKKYVDECGAANFFGIKDDTYVTPKSSSILPSITNKSLMQIAEDLGMKVERRPISEDELDSFEEAGACGTAAVISPISHLDDMETGKVYNFGDKPGPWSTKLYETLRSIQYGTIEDKHGWTTVVIE
>CP022040|1079793:1132954|1127933_1128581_+|ASE17405.1|DBSCAN-SWA
MFSLFNKNKIEEQDFYFLKNVICILPTKWDFLIKQINSRFIIGKCKNTLYGKGFYNLVLNREYYDYSNYKYPELVTLSGIYIWNKKKREYVEVQLYISFGTIIGYYFNSKYNHLDWHKVSLNTLKENNYANHSNGKKDIIQMLSQKLSPEELKKIDIGDINELQFEGNTYYTIKNLNDGDYMAINNTGEVFIITHAPFEVKKLYSSIRAFLHQTL
>CP022040|1079793:1132954|1101388_1102318_-|ASE17383.1|DBSCAN-SWA
MCKTISPFFYYSELKRYERKKSFIGHQYNQINDRRLCRLHFFPDSTDIFQDVGIADGLSIVFMDYAKKKEGFIYAYSKGGKTMEVAMSNPGDILMALDPIAEQISQKIQAIVIKHHFEYIYGSVLPRSLFSIESDFVEQNPTLVRPLQEGIILGEDEIKLFTNDKAGKAGRASWFIAHKSVIKTGLDYLHRWKVIVSSANAGGQKRSNQIAVLDNHSVFGRSRVALKTFETEQEARNFYAYCQTDFIRYAFLLTDEALTSLGKLVPDLLDYTNDNGIIDYAQDVNTQLYRLFGIDEEMQAIIKQTLSER
>CP022040|1079793:1132954|1126976_1127402_+|ASE17404.1|DBSCAN-SWA
MIINYIFFRIHMAYKAKHDSAMLNSILYLSCVLMFVLLPIAGVVLEIARKGGRINTAFFILYFISILGFVTMKYGNKKMVERLYKKYSQHKFNRIIPTYCFFFILPICIILGMSIYIIILKNFVDIDKIRDIIYNILTSSY
>CP022040|1079793:1132954|1130516_1130786_-|ASE17407.1|DBSCAN-SWA
MTIKPLADRVLVLPAQAEEKVGGIIIPDTAKEKPQRGKVVAVGNGTKDEEMILKVGDEVLYGKYAGTELENEGEKYLMMRQSDVLAVVE
>CP022040|1079793:1132954|1126112_1126352_+|ASE17402.1|DBSCAN-SWA
MCEYLNKNDLNSFDCYIGLGISKGLSVGNLGLLYGTSAVQGENGYNKTDFSRSYGVSLNANPARFDMSKGGGRTWIPFF
>CP022040|1079793:1132954|1089693_1091115_-|ASE17379.1|protease|DBSCAN-SWA
MKQTYLRNYIIFLFILVSATLLASNKSGGLISYPGGKCYMFRVTLKDKNGTPYSLDKPEKFLSKASLLRRERQGLKLDSTDLPVSPDYIQQIKKRGGKVVAVSKWNNSVLVRGNNRQTLEDLKVLSFVKDSKLVFVSPDSIRPLSQRVRYNSELQSLDSTVHDYYGMGKGQIESLNGRKLHNLGFMGQGMTIAVLDAGFMNVDKIAAFRNLNIKGTHNFVAGYDNDVYKEMDHGTKTLSTIAMNQPTVFVGTAPKADFWLLRTEDYSTESPAEEDFWIAAVEFSDSVGVDIISSSLGYHGFDDISMNYRYADLNGRTAAISQAASRLASKGMILVNSAGNDGMGTWKKINVPADAHDILTVGAVSLDKVNAPFSSIGPTADGRIKPDVMAYGCPTNVVSGRGYIIPDNGTSFACPLIAGMVACLWQACPNKSAKEIIDIIRQSGNNCQSPDNIMGYGIPDFWSAYQSATRYNQ
>CP022040|1079793:1132954|1088131_1088320_-|ASE17377.1|DBSCAN-SWA
MKEIKYEEAVHKLEAIVDKMERGELDIDSMAAQLKEAQELVKLCKQKLKRTDNEIQKLLEKQ
>CP022040|1079793:1132954|1097386_1101349_+|ASE17382.1|DBSCAN-SWA
MATFESSLKPRLIYVFAIADKQHEGSLKIGETTLGDDTGDTLAAPNSDVLNQAAKARIDQYTKTAGISYELLHTELTFYIRGGHICSFNDKQVHNVLERSGVKRKEFKGATEWYSCDLETVKRAIAAIKEGKDSLGAGEVTHTENPIILRPEQKDAVERTLKQFRRGNQMLWNAKMRFGKTLCALRVAKEMGAVRTIIVTHRPVVDASWFEDFGKTFHDSPEWHYGSHNKGESFASLQRLAGQGKKYVYFASMQDMRGSKEVGGKFDKNNEIFSTTWDLVIVDEAHEGTQTELGKAVLEQLISKNTKILRLSGTPFNLLDDHKEEEVFTWDYVMEQKAKIDWEINHLGDTNPYASLPAIHIYTYDLGRLMSEYSDEEKAFNFREFFRTREDGSFVHERDIDHFLTLLTTDDEESLYPYSNDSFRQIFRHTLWILPGVKAAKALSRKLAKHPVFGLFNVVNVAGDGDEEEESRDALELVNKAIGSDPDQSYTITLSCGRLTTGVSVKPWTGVFMMAGAYSTSAAGYMQTIFRVQTPYTHNGRMKTDCYAFDFAPDRTLRVLAETAKVSHKAGKQTEDDRKLLGDFLNFCPIIAIDGGQMKQYKVETMLAQLKRAQIEKVVQDGFENGALYNDELLKLTDVELKEFDDLKGIIGKTKAMPKSGDIDINRQGLTNEQYEEKEQLEKKKKKDLTPEEKKRLDELKAKGDQRREAISILRGISIRMPLMLYGAEMVDEDKELTIDNFAKLMDDQSWEEFMPRGVTKQVFARFKRYYDPDIFREAGKRIREMARMADKFTIEERIARLASIFATFRNPDKETVLTPWRVVNMHLGDSLGGYCFMNEDFTSNLDIPRYIEHKGVTTEVFHPQSVILEINSKSGLYPLYAAYNIYRTRLEQAREKYGEVNRATALMLWDLTLEENIFVVCKTPMARYITMRTLRGFRNTNVHTKYYPNLIESIITEPDSVVNMLRSGKRFWKINNDENMKIDAIIGNPPYQVTSENTSDAPVYHLFIDLASLLAQRVSLLTPARYLFNAGKTPKDWNTKILNDEHFKVVDYWANSTDVFPTVDIKGGVAVMYRDSKLNFGKIGTFTAYKKLNIIANKVCKISENGLFAELIYAPESYRLSDKLHEDYPWAKERLSMGHPYDITTNIFEKLPEIFKETYQIKEEEVRFYGRYKNERCYRWIKREYVDFHPNLDKYKVIVPKSNGSGAIGEVLSSPLIGEPLIGVTQTFLTIGAFDTRTEAEACLKYVKTKFARTMLGLLKATQHNPKDTWRLVPLQDFTAASDIDWTLSVAEIDQQLYHKYGLEAEEIAFIEEKVRAMG
>CP022040|1079793:1132954|1116044_1117607_+|ASE17395.1|DBSCAN-SWA
MIDTTMNNYTLYNSKHSSTLLITTSIAALGISFPAKAQQVNTQPNIILFMVDDMGWQDTSLPFADSITANNRKYDTPNMERLASEGMMFTDAYATPISSPSRCSLMTGMNMARHRVTNWTLHRDKMTDGKRDGVTLPDWNYNGIAQSGNVAHTTKAISFVQLLKNVGYHTIHCGKAHWGAIDTPGENPCHFGFDVNITGTAAGGLATYLSERNYGFAKDGKPTSPFAIPGLERYWGTGIFATEALTQEAIASLEKAKKYDQPFYLYMSHYAVHVPIDRDMRFYPTYRARGLSEKEAAYASLIAGMDKSLGDLMDWVAKAGLKRETIIIFMSDNGGLASSSYWRDGELYTQNAPLKSGKGSLYEGGIRVPFIVKWNNIVKPNTRSHAPIIIEDLYPTLLSMAGIKNYHVPQKIDGQDITPILRGKQQGDKKRQLIWNYPNIWDGEGLGISLNCAIREGQWKLIYSYLTGQKELYDLSSDLSEKNNLASSHPQLVERLYRHLTSKLHKMNAQKPIVEGEKRK
>CP022040|1079793:1132954|1111540_1112533_-|ASE17392.1|transposase|DBSCAN-SWA
METSPVTCRTLEEFYHINGRSFEKQYKETLSGYRSWDQLSHAQKWLLFEDNIGKNIAIDETSLSNGELYTIITNRDKHGKQGCLVAIVAGTKFLDVCKVLDKIDEKKREAVEEVTLDLSDSMRKIVRHCFPKAKRVIDRFHIQKLASDAVQQMRIEYRWAALQQANDEKENAKLEKIAYQPLTFENGDTRSELLVRSRYLLFKSSEKWTDEQKLRAKILFREYPDIKKAYGLSHSLRMIFAKNTIKNAARLSLAKWYNNVAEAGFHSFNVIAATFYEHYEDILNFYINRSTNAAAESFNAKIKLFRANLRGVVDKSFFLFRLAKIYAYPH
>CP022040|1079793:1132954|1080782_1083308_+|ASE17372.1|DBSCAN-SWA
MIKKIFKFIRSIFRGIFNFFPWYAKLYKGRAWYTKMAVGTVSFFVAIFLYLGMVDINFLWLFGKSPGFIDIKTPPTYAASEIYSADSVLIGRFYKENRTPVKYEEVTPAFWNALISTEDERFYSHNGIDFMGIGGAIKDAVTGSGGRGASTITQQLAKNMFRVRTQYSSGLLGHVPGLRMLIMKSKEWIIAVKLELIYSKKEILTMYANTVDFGNNSFGVKTAAKTYFNTSPSKLSIDQAATLVGMLKATTYYNPILHPKNSIRRRNTVLYNMVTHNVLPHDEYALYSKRPMKLDIHVEENYDGQAQYFREYISEYFKDWMKDNGYDLYSSGLKIYTTIDTRMQKYAEQAATKQMEKVQQTFDNHWRGMQPWRDAKGNEIPGFIEGIAERQPFYKKLLQKYPNQPDSVLYYLNKPHKVTLFDYEKGHIEKEMSSMDSIRYMVKFMHCAMVAMEPETGAVRAWVGDIDFKTWKYDKVVAQRQPGSTFKLFVYSEAFNQGLTPCDKRRDEYISMQVLDKKTGQMKTWTPHNANGRFSNDSITLKSAFARSINSIAVRLGQEMGIKNIIRTAQEMGIKSPLDDEPSLALGSSDVNLLELVNAYSTVANDGEYHVPVVVTRILDKDGNEVYVAPKDHERALPYKTAFLMQEMLKAGVNEGGGTSQALRHYTFGDTDWGGKTGTSNNHSDAWFMAVSPKLVVGAWVGGEYRSIHFRTGALGQGSKTALPICGEFIYSLMRDKAFQKYHAKWQLDPDEDIDPSMYNCQPTVVRRAAPDSLRDFTTGHRRHQEEEEEPIDGHENTDEGGFILEPAPQPTPERQGNSSNNESPQIIKKAKKPRSEDMEI
>CP022040|1079793:1132954|1124819_1125017_+|ASE17400.1|DBSCAN-SWA
MGAEGVHESVHAADPVEVNRDIRSSQPGQKKLSEFIYERKARLMEAKFREELKKNKDNQNEKRKL
>CP022040|1079793:1132954|1091918_1093334_-|ASE17380.1|DBSCAN-SWA
MDEKQMDCSKKTLRRKLDLLLRTGQILMESSADTSRVKRNMERTAAYLGLPKENLHMNIDYYMLQVNVSDEYHSFSKMQRCDKHVINMLAIQEVSKLSWRAIQKDYSLDKYEEELEKIANGKHYYKDWIIAIGAGLACGGFCIQFGCDWTAFFYASIAAILGNRLRMFLNHSGSNLYANFAVAAFVSTILAWLSSFLSTPTVQAALPEFLRPILFTETPWHPLLACALYIVPGVPLINAVNDLLDNHINTGLVRAMNTLLIVIAMSFGIMLAIKCGSFDGFAKDLPTIPHHSFYVYAVAAAISAMGFATIYNIPYRLMPWIAVGGIICVCTRNFVFLDPSTGNAGLGLGIVVGSLCGSALISIINIKAVHILHTPHQCITIPAVIPIVPGVLMYRALYGFMGMQGVVGEVTHAMSFAINGSLVLVCIALGVAIPNIFAKKWIAPHRKAKLQRMIDERRQRGKFVDLHQYNI
>CP022040|1079793:1132954|1108161_1109343_+|ASE17389.1|DBSCAN-SWA
MEGDHIKINKWLLPFSWLYGLGVRLRNELFELNILKSRQFDIPVISVGNITVGGSGKTPHVEYLIRLLKDKMKVAVLSRGYKRKSCGYVLANENTPMREIGDEPYQMKTKFPDIRVAVDKKRCEGIDRLTSDEETKDTDVILLDDAFQHRYVHPGINILLVDYHRLIIYDKLLPAGRLREPLSGKNRADIVIITKCPKSLNPIDYRVLSKAMELYPFQQLYFTTLDYCDLEPIFSKGRNIPLTEIRGKNILLLAGIMSPKQLELDLNSFTGNNALTTLSFPDHHAFTTKDIHRINETFAKMPEPKLIVTTEKDKARLVDIDKLSDDVKENIYALPIKVSFMLDKEEVFNKKIISYVRKNSRNSILAKREDDHKSKDSHHSGHRPRTISFRDNR
>CP022040|1079793:1132954|1102369_1103602_+|ASE17384.1|transposase|DBSCAN-SWA
MNKSTHFIGQPLYVQLLNYFNRDKILSLSQAQGGEHYIKKFDAWHHLVVMLYAVMLRLDSLREIKASLFANVNRFNHLGLKHFPCRSTLSDANKRRDSEIFGSIYMNLYEKYRHELYSDSRNCGQPKWLKNLKIIDSTTISLFSNLVFKGVGRNPKTGKKKGGIKVHTEIFANENVPSDIKFTSAASHDQFALIPERYANEDLIAFDRAYINYEKFSELTQRGVIYVTKMKNNLSFERIADTDYQMTTDYGAVRVETILFHKHTKEKDIYHKARKITYQDKTKKGKIRFISLLTNDFQMSAEDIIAIYKRRWQIETLFKQIKQNFPLRYFYGESANAIKIQIWITLIANLLITLVKNKIKRPWSFSGLATMIRILLMSYVSIQSFFERPHRDWDRLITQVKAPPEELSLF
>CP022040|1079793:1132954|1096362_1097367_+|ASE17930.1|DBSCAN-SWA
MNDMKPNIDISENELLRQSEEILVELLRDHTTQKNIFWATDDYASLGEAYSYHAPITIPCITGDNGFIIQPRVLKTREEQANRTKDKAEVFTPSWVCNAQNNQVDEAWFGRKDVFNHEHPETKTWTATTKPILFPDGKTWKDYVRSTRMEITCGEAPYLASRYDTTTGAFIPLSQRIGMLDRKLRVISENTTTTGEWLKMAQEAYKNIYGYEWQGDNLLLAREALLMTFIEYYTEKFGEKPQERSIKYIAYIIAWNIFQMDGLKGVVPDSCRHNEVIIEQTLFEAMERTVLCPGCQNETYKGHNGIYCLIRDWGHKDPVTGENNRKIRFIDLIK
>CP022040|1079793:1132954|1130986_1131694_+|ASE17408.1|DBSCAN-SWA
MKQLTKTITNKLQALSDAEKREIFPKFFKAGKGEYGEGDRFLGVTVPNIRAIAKLHKDISIEEIRELIQSEWHEVRLCALIIMVENSKKKDEALRKELFNLYLSQTKRINNWDLIDLSCRFIIGEYLLDKSRDILYHLAQSPLLWDNRIAIVSTYAFIRKGQLEDTYALSDLMMQHPHDLMHKAIGWMLREAGKRDSERLYDYVMSHRADMPRTMLRYAIEKFSPKERAILMKRA
>CP022040|1079793:1132954|1123075_1124068_+|ASE17399.1|transposase|DBSCAN-SWA
METSPVTCRTLEEFYHINGRSFEKQYKETLSGYRSWDQLSHAQKWLLFEDNIGKNIAIDETSLSNGELYTIITNRDKHGKQGCLVAIVAGTKSLDVCKVLDKIDEKKREAVEEVTLDLSDSMRKIVRHCFPKAKRVIDRFHIQKLASDAVQQMRIEYRWAALQQANDEKENAKLEKIAYQPLTFENGDTRSELLVRSRYLLFKSSEKWTDEQKLRAKILFREYPDIKKAYGLSHSLRMIFAKNTIKDAARLSLAKWYNNVAEAGFHSFNVIAATFYEHYEDILNFYINRSTNAAAESFNAKIKLFRANLRGVVDKSFFLFRLAKIYAYPH
>CP022040|1079793:1132954|1112498_1112885_-|ASE17393.1|DBSCAN-SWA
MEEKYLYQLAEFVLPSDVLHYFSIVKIESDTSLLRIYLDEKMEKELSDDLHFESKGFMEAVEVTDFPIRDHKVILVLRRRRWIDIRTGKSFSLPLQIDITASGTRYSKEFGAFLKETYGDIPSDLPYA
>CP022040|1079793:1132954|1132108_1132954_+|ASE17409.1|transposase|DBSCAN-SWA
MYSCKDCGRQFQGGLRINNISLWNDYLTANRTISDLSTLYKCSERTIRRRLSLVVDSFTATYPKSAVIILDTTYFSKTFGVMLFQDASSGKILYRKFVKNETNRDYLDGLRYITERGTMIKAVVCDGHVGLLQAISFCPVQMCQFHQFQIVRRLLTNNPHLPAGVELLALMRRMFSMRKEEFITAFDKWCDKWKEFLNERTLLISGKTTYTHRRLRTARRSIKTHLPWIYTCEEYPDMQIPNTTNLLEGFNSQLKRALHNHNGLNEANKKKFIDGFINTKK
>CP022040|1079793:1132954|1083606_1085382_+|ASE17373.1|DBSCAN-SWA
MSQKKVNIDVNTIDLDNTELQKALQIIQFTNNSLFLTGKAGTGKSTFLRYIAATTKKKHIILAPTGIAAINAGGSTLHSFFKLPFYPLVPTDKRYSARNLRSTMKYNGDKCKLLREVELIIIDEISMVRADIIDFIDKVLRIYNRNMREPFGGKQLLLVGDIYQLEPVLKEEDRRLLQPYYPSSYFFDAKVFQDYPLVSIELNKVYRQNDPHFISILDHIRTNQVTDTDFNHINERVGASLENTNKPEGDFTITLSTKRDTVDWINNEGLDSLDGDPVMFLGEIKGEFPESSLPTPIELNLKVGAHIMFIKNDIEKQWVNGTLGIIIGIDEEAGILYVHTEEGDDLQVQREMWENIRYRFNEEEQRIEEEQIGTYIQFPIKLAWAITVHKSQGLTFKNVNIDFTGGVFAGGQAYVALSRCTSLEGITLKEPLRRNEVFVRSEVTHFARHYNDNNIISTVLKQSKADKEYYDAVCAFDKGDFDAFLRSFFLAIHSRYDIERPAAKRFIRRKLDLINQLRNENEELKRQQDKKNEYLKELSVEYVMMGKECEREEMNEAAIANYEKAIALYPDNPTAQKRLKKLKPSTEKDNK
>CP022040|1079793:1132954|1094082_1094823_+|ASE17381.1|DBSCAN-SWA
MLYIFAQIVMRKYIFTAIIVSVTLTSCFSFFPNRYEKALVYNGFRANTNTGIATKVNIKGYYSLVNDSTDSVTVGGSSIISKGGMSTLAGYNPFILYEDGTYGNILFNAVEKDFYANEHYKRANVELYKECTPLNNIYLMRSGYYKLKEDTICVTTYIYYLLRTELVLLRYKIIDSSHLLLLDETYISGNKNENDTCVQNRIFEFIPAKTLPSPSLFPIKKKRWAWANKKDWKQFKHSIARTSKNK
>CP022040|1079793:1132954|1085381_1085915_+|ASE17374.1|DBSCAN-SWA
MEQKKSLSKIIATIVFGIVFIIIAIVSCNQSKTIEGSNNGDTVAAKEFTPHVENGKLNIDLQSITSIRFPKYKTTKAIPFIPDSVSLAADEESVESGNYSATLLLDTIPNKEFYQRIDLAAQHDTCWDINKFAYTYERKDKAGGVYKVVFSKGGQQIFVTHLNKDMIKNTNQTKPNK
>CP022040|1079793:1132954|1113656_1115738_+|ASE17394.1|DBSCAN-SWA
MIMKKRTIVLFGMLLMVLTAVAGGKIKVACVGNSVTWGMTIIDREKNCYPAQLQKMLGDKYEVRNFGHSGTTLLQHGHRPYVDQQEYQDALNFKADLVIIHLGLNDTDPRNWPEYSEEFNADYIRLIDSFRQANPKAKIWICLMTPIFERHPRFESGTRDWHAQIQKHIRQVATATRVPLIDLNTPLYSRPDLLADAIHPNAEGAKIIAETVYGALTGNYGGLALSPLYTDGMVIQRNKPIVFRGKANAGETVKVNFNGHMLSAITNDAGKWKITFPAEKAGGPYKAQISTKKEKLTIKDIYVGEVWLCSGQSNMELPVNAVQSRTQDLNEADSQTHLHLFNMSAIYPTTAIAWSANACDSVNRHQYLHIGPWRNCSRESLGGFSAVAYHFGKKLADSLQVPVGVICNAVGGTTTESWIDRHTLEQRMPAILRDWYHGDFGMKWARERALQNISVSKNPLQRHPYAPAYMFETGMLPLKGYSIKGIVWYQGESNAHNMELHERLFPMLQKSWRNFFHDPELPFYFVQLSSLNRPSWPRFRDSQRRMASRLRNTWMAVTTDVGDSLDVHYTNKKPVGERLGLQALHHSYDYNIESDGPICHSVSAKDNGIELQFIHAKSLSAKGSRLIGFEVAGADGIYYPAEAQITSSNTILVKSSSVTRPLYVRYGWQPFTRANLVNEVGLPCSTFQWAVKK
>CP022040|1079793:1132954|1095323_1096370_+|AVV27025.1|DBSCAN-SWA
MSFINTVNTEDLYHKVARLIEDSRARMVTSINLAEVYTKFRIGQYIVEEEQRGETRAQYGKQVLQSLATKLTKNFGNGWSYSNLRQMRQFFVIYSNLTTTGCQIDDFTPKFTLSWSHYLLLMRVEDPDARRFYEIESSQQQWSKRQLSRQIGSSLYERLALSRDKEGVMRLAQKGQVVEKPSDIIKDPITLEFLGLKPDSLYSESKLENAIIGRMQQFLLELGKGFLFEARQKRFTFEERHFYVDLVFYNRLLQCYVLIDLKTGSLSHQDLGQMQMYVNYYDRYIRQDFENPTIGILLCENKNDALVELTLPPNANIYASAYQLYLPDKTLLQSKVKEWISEFRDNAE
>CP022040|1079793:1132954|1103954_1104758_+|ASE17386.1|integrase|DBSCAN-SWA
MVKSFKQQLKKEELSDNTITAYLYAVEDFERKYSCFNRENLLLYKADQIEQFKPKTVNLRIQALNKYLEFIGKPRLRLKSLKIQQKTYLENVISNADYQYLKSKLKEGEEEVWYFLVRFLGATGARVSELIQFKVEHVRVGYFDIYTKGGKVRRIFIPQDLCMETKAWLKRANIDLGYLFLDKHGKQITPRAIRHKLQRFAHQWGINSKVMHPHSFRHRYAKNFLESFNDVVLLADLMGHESIETTRIYLRRTSNEQQAIVDKIITW
>CP022040|1079793:1132954|1103685_1103949_-|ASE17385.1|DBSCAN-SWA
MILYLSNIAKISPIYAIIGNPPYQLTVAKKDTDNGQKAVVNIFQHFQLLADRLAPRFSSLIYPAGRWIHRSGKGLANFGYNQIIAVR
>CP022040|1079793:1132954|1120189_1121542_-|ASE17397.1|DBSCAN-SWA
MNVLDYVKAFNEFLWNSFLMYALLGVGIFYTVYLGFPQIRHLNLAFKYAFGPIFKKRKPGETKVNSFQALATAVAAQVGTGNIGGVATAIASGGMGAIFWMWVSALLGMSTIFSEAVLAQKYKKEYHGETVGGSAYYLYYGLGSKWLAVCFSVAIVLALGFVGNMVQANSISIALNNAFHIPSYIIGIVLAAVVGVVIIGGQRRITAIAELLVPFMAVVYILGSLVIIYMFADQLPHVIRTIFQDAFSMKSAAGGAAGTVMKYAIRYGVARGLFSNEAGMGSTPHAHALADVKDPSEQGFVAMAGVFVDTVLICTSTAFVIMLTGSFQNLSLKSVAITQEGFEIAFGNGGIIFLAISLIFFAFTTIIGWYMFAEMNIKFMFGKKGILSYRALVVLFVFLGCLFAADMVWELADTFNGLMVIPNLIGIIFLAPQVKKIYKNFLANRKENNS
>CP022040|1079793:1132954|1122723_1123110_+|ASE17398.1|DBSCAN-SWA
MEDTYLYHLASLVLPKDVLKYFSVVKIEPSPSLLRIHLDEKMEKELSDDLHFESKGFMEAVEVTDFPIRDHKVILVLRRRRWIDIRTGKSFSLPLQIDITASGTRYSKEFGAFLKETYGDIPSDLPYA
>CP022040|1079793:1132954|1118019_1119753_-|ASE17396.2|DBSCAN-SWA
MKSTFVTKMVKPIEENSLFFMFMLLVGAFTNVSHRNVFGYIELIADLYIICFLLSLCQQTIRQGLVIMLSSVVYVVAIIDTCCKTLFDTPITPTMLLLAQETTGREATEFFLQYLNLKLFFSAADIILFLALCHIVMAVKKMTFPTSYLKQPFVAFALMFTIFVGIALSVYDKVQLYRVKNLSELEVAVTNGFAHLYHPVERIVYGLYSNHLIAKQVDGVIMANQQIKVDSCSFTSPTIVLVIGESANRHHSQLYGYPLPTTPYQLAMMNGKDSLAVFTNVVSPWNLTSKVFKQIFSLQSVDEKGDWSKYVLFPAVFKKAGYHVSFLSNQFPYGINYTPDWTNNLVGGFFLNHPQLNKQMFDYRNVTIHNYDEDLLNDYKDIISYKKPQLIIFHLLGQHFQYSLRCKSNMKKFGIMDYKRMDLTDKEKQTIADYDNATLYNDYVLNKIVEQFRNKDAIIVYLSDHGEDCYGKDVNMAGRLTEVEQINLRKYHEEFEIPFWIWCSPIYKQRHRKIITETLMARSNKFMTDDLPHLLLYLAGIKIKDYFEERNVISPSFNSNRRRLVLKTIDYDKALYQ
>CP022040|1079793:1132954|1124997_1125657_+|ASE17401.1|DBSCAN-SWA
MRKENYKIKHKYLLGIFIISMLIFSGPLYSQNNIIPSNLRKSLYKLYHYNTTWKSTISKLSCVEGKKHDGVYTFRLNYQPHYPTRVFFISNNTPYTIESLGFENTTGVLLEACHFLSSKHQTNSYIKSILSGVYKYLFAEYGLTYGSDFFDKKPDFSNERDKMRFIIHRVNNVDKLRKQALYLRTDRKIIPDSITNYIKGNNLNDEEALLFLRYIILNN
>CP022040|1079793:1132954|1079793_1080705_+|ASE17371.1|tRNA|DBSCAN-SWA
MKNKTLIVITGPTGVGKTETTLRIAEHFNVPVINADSRQIFSEIPIGTAAPTAEQQQRVQHYFVGNHHLEDYYSASLYEQDVLNIINSQHTPISLLSGGSMMYIDAVCNGIDDIPTILPEIREKMMKRLEAEGLEQMCNLLRELDPEHWKIVDRNNPRRVIHALEICIQTGKTYTSFRSNTIKDRPFNIIKVGLNRDRDELYNRINQRVLDMIEEGMIEEALQVYPKRTLNSLNTVGYKEIFEYLDGLTTLDEAIFKIQSNTRRYARKQLTWYKKDTAFQWFNPDNIEEILNYVHTMISNTSK
>CP022040|1079793:1132954|1105228_1106281_-|ASE17387.1|DBSCAN-SWA
MKHIILAIDSFKGCLSSVEAEDAAEQGLRERWQEVKVVKVPVTDGGDGMLEVFLQLFDCKEITINCHDALMRPIQASYAVCADNTVVIETALSCGINFLKQQELNPLRATTYGLGELFADALQRGYRKFVVGLGGSATSDCGLGMLAALKDIFGKNWRDKFLRDLDITLASDVNNPLFGERGAAVIFGPQKGATPEMIVCLDRRARTFARMAAAQLGFDCSLNNGAGAAGGLGYAFMQFMNAKMSSGADVLLETVNFNSLIEDADLIITGEGSADSQTLMGKIPIRVLEYGLRKNVPVMLIAGKVKDAAALLKAGFSQVQCITPTDMMLTEAMKPTVAKENIRKAIIQLN
>CP022040|1079793:1132954|1109224_1110034_+|ASE17390.1|DBSCAN-SWA
MYEKIQETASWLKERMTTSPKTAIILGTGLGQLASEITDSYSFSYQDIPNFPVSTVEGHAGSLIFGRLGGKDIMAMKGRFHFYEGYNMKDVTFPIRVMHELGIETLFVSNASGGMNPSFKIGDLMIITDHINMFPEHPLRGRNFPTGPRFPDMHEAYDHKLVDLADSIAKEKNIEVQHGVYMGVQGPTFETPAEYRMYHKMGGDAVGMSTVPEVIVARHSGIKVFGISVITDLGGFDVPVKVSHEEVQEAANAAQPRMTEIMREMIKRS
>CP022040|1079793:1132954|1128738_1130364_-|ASE17406.1|DBSCAN-SWA
MAKEIKFNSDARELLKSGVDQLANAVKVTLGPKGRNVVIGKKFGAPQITKDGVTVAKEVELEDNFENAGAQLVKSVASKTGDDAGDGTTTATILTQAIVTEGLKNVTAGANPMDLKRGIDKAVAKVVDHIKASAEVVGDNYDKIEQVATVSANNDPEIGKLLADAMRKVSKDGVITIEESKTRETSIGVVEGMQFDRGYLSGYFVTDTDKMECDMENPYILIYDKKISNVKDFLPILQPAAESGRPLLVIAEDVDSEALTTLVVNRLRAGLKICAVKAPGFGDRRKAMLEDIAVLTGGVVISEEKGLSLDKATLEMLGTAKKVTISKDNTTIVDGAGEKEAIKDRVAQIKNEIAASTSSYDKEKLQERLAKLSGGVAVLYVGANSEVEMKEKKDRVDDALCATRAAMEEGVVVGGGTTYIRAQEALKDLKGENADEQTGINIVCRAIEEPLRQIIANAGGEGAVVVNKVREGKGDYGYNARKDVYEDLRAAGVIDPAKVSRVALENAASIAGMFLTTECLIVDKVEDTPAMPAAPGMGGMM

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ASE17371.1|1079793_1080705_+|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
ASE17372.1|1080782_1083308_+	penicillin-binding protein	NA	NA	NA	NA
ASE17373.1|1083606_1085382_+	hypothetical protein	H7BUJ6	unidentified_phage	1.1e-81	40.9
ASE17374.1|1085381_1085915_+	hypothetical protein	NA	NA	NA	NA
ASE17375.1|1086036_1086522_-	ferritin	NA	NA	NA	NA
ASE17376.1|1086987_1088004_-	branched-chain amino acid aminotransferase	NA	NA	NA	NA
ASE17377.1|1088131_1088320_-	exodeoxyribonuclease VII small subunit	NA	NA	NA	NA
ASE17378.1|1088360_1089665_-	exodeoxyribonuclease VII large subunit	A0A167RNX3	Powai_lake_megavirus	1.8e-15	39.8
ASE17379.1|1089693_1091115_-|protease	serine protease	NA	NA	NA	NA
1091372:1091391	attL	NA	NA	NA	NA
ASE17380.1|1091918_1093334_-	hypothetical protein	NA	NA	NA	NA
ASE17381.1|1094082_1094823_+	hypothetical protein	NA	NA	NA	NA
AVV27025.1|1095323_1096370_+	DUF1016 domain-containing protein	Q9JMP5	Wolbachia_phage	1.9e-28	28.8
ASE17930.1|1096362_1097367_+	restriction endonuclease subunit M	NA	NA	NA	NA
ASE17382.1|1097386_1101349_+	DEAD/DEAH box helicase	A0A1V0SII8	Klosneuvirus	7.3e-12	24.3
ASE17383.1|1101388_1102318_-	hypothetical protein	NA	NA	NA	NA
ASE17384.1|1102369_1103602_+|transposase	IS4 family transposase	NA	NA	NA	NA
ASE17385.1|1103685_1103949_-	hypothetical protein	NA	NA	NA	NA
ASE17386.1|1103954_1104758_+|integrase	integrase	A0A0H4TI16	Erysipelothrix_phage	9.3e-23	28.1
ASE17387.1|1105228_1106281_-	glycerate kinase	NA	NA	NA	NA
ASE17388.1|1106376_1108155_+	signal peptide peptidase SppA	A0A2I6UH21	Salinibacter_virus	7.8e-14	31.9
ASE17389.1|1108161_1109343_+	tetraacyldisaccharide 4'-kinase	NA	NA	NA	NA
ASE17390.1|1109224_1110034_+	purine-nucleoside phosphorylase	Q5YBA4	Grouper_iridovirus	1.1e-60	43.6
ASE17391.1|1110133_1111243_+	thiamine-monophosphate kinase	NA	NA	NA	NA
ASE17392.1|1111540_1112533_-|transposase	DDE transposase	A0A2D1GQC1	Lysinibacillus_phage	8.8e-07	22.1
1111384:1111403	attR	NA	NA	NA	NA
ASE17393.1|1112498_1112885_-	hypothetical protein	NA	NA	NA	NA
ASE17394.1|1113656_1115738_+	sialate O-acetylesterase	NA	NA	NA	NA
ASE17395.1|1116044_1117607_+	DUF4976 domain-containing protein	NA	NA	NA	NA
ASE17396.2|1118019_1119753_-	hypothetical protein	NA	NA	NA	NA
ASE17397.1|1120189_1121542_-	sodium:alanine symporter family protein	NA	NA	NA	NA
ASE17398.1|1122723_1123110_+	hypothetical protein	NA	NA	NA	NA
ASE17399.1|1123075_1124068_+|transposase	DDE transposase	A0A2D1GQC1	Lysinibacillus_phage	1.2e-06	23.2
ASE17400.1|1124819_1125017_+	hypothetical protein	NA	NA	NA	NA
ASE17401.1|1124997_1125657_+	hypothetical protein	NA	NA	NA	NA
ASE17402.1|1126112_1126352_+	hypothetical protein	NA	NA	NA	NA
ASE17403.1|1126333_1126678_+	hypothetical protein	NA	NA	NA	NA
ASE17404.1|1126976_1127402_+	hypothetical protein	NA	NA	NA	NA
ASE17405.1|1127933_1128581_+	hypothetical protein	NA	NA	NA	NA
ASE17406.1|1128738_1130364_-	chaperonin GroEL	A0A219YK78	uncultured_virus	5.6e-184	62.3
ASE17407.1|1130516_1130786_-	co-chaperone GroES	A0A221S3C8	uncultured_virus	6.7e-18	54.0
ASE17408.1|1130986_1131694_+	DNA alkylation repair protein	NA	NA	NA	NA
ASE17409.1|1132108_1132954_+|transposase	transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>CP022040|1273406:1281876|DBSCAN-SWA
TATGGCAATAGGCAAATGGATTGGTGGCGCATTAGGATGGATACTTAGCGGAAGTATGCTGGGTGGTTTAGTTGGCTATTGTATAGGAACAATGCTTGACGAAGCATTTGCAGGCGATAATAGAGGTGGTGATAGGCAGAACGGATATGGCGAGCAAAGTCATTTTGGAGGCACGCGTCCGTTTGAAGAAGACCGCAACTCCTTTTTGTTCTCTATGCTTGTCCTTTCCTCTTACATTATAAAAGCCGATGGAAAGATAATGCACTCTGAGATGGAATATGTACGCCAATTCCTTCGTCATAACTTCGGCGAGCAGGCTGTAAGCCAAGGAGAATCAATTTTGCTAAAGTTATTTGATTTACAGAAGCAACAAGGCCCTTACCAATTTAAAGAAACAATCCGTAAGAGCTGTGTTGAAATACATTTTCATACAAGTGTCAGTCAACGCCTACAACTACTAAACTATCTTGTCATCATAGCAAAAGCTGATGGCATCGTAAGCCCAGAAGAAGTTGTTGCACTGAAAGAGATTGCCTCATATCTTGGGCTTTCTGCGCAAGACATAGAGTCCATGCTCAACTTAGAAAGTGGAGCAAAAGCAAGTAGCAACATTGAAGATGCTTATAAGGTGTTAGGCATATCTCCATCAGCAACTGATGATGAAGTCAAGGCTGCTTACCGCAAGATGGCACTTAAACATCATCCAGACCGTGTTTCTACGCTTGGAGACGATATCCGAAAGGCTGCTGAAAAGAAGTTCCAGGAGATTAACGACGCCAAAGAAAGAATCTATAAAGCAAGAGGACTGTGAGGAAAGTGGACAGTTTTATAATTGACAAGTAAATGCTAATCAATTCACAACAAACATCTTCATTAAGAAACAATCATAAATTGCACTATGGCAACAAGACTTAAAATAAAAACAACAGAAGGTGATATCATTATTCGCCTTTATGACGAGACTCCAAAACATCGTGATAACTTTTTAAAGCTTGCAAAGGAAGGGTATTTCAATGGTACACTCTTCCACCGAGTAATAAAGGATTTTATGATACAAGGTGGAGATCCCGATAGTAAGAATGCTCCGAAGGGTAAGATGTTAGGTACAGGTGGACCAGACTATACCATTCCTGCTGAGTTTGTGTATCCACAATACTTTCACAAGCGTGGTGCATTGAGTGCAGCCCGCACAGGTGATGAAGTTAATCCTGAGAAAGAAAGCAGTGGTAGTCAGTTTTACATTGTATGGGGAAAGACCTTTAAACCTGCAGAACTGAAACAAATGGAGCATCAGATGGCAATGCAACAAGAGCAGCAGGTATTCAATCAGCTTACAAGAGAACATCACGAGGAGATAATGAATTTAAGACGTAATCGTGACCGTGTAGGACTGCAAGAGCTACAAGACAAACTAATAGAACAAACAAAAACAACTTGTAAGCAACAAGGTAAGCCTTCCTTTACAGAAGAACAAATAGAGGTTTATACTAATGTTGGTGGTACTCCTTTCCTCGATAATCAGTACACCGTCTTCGGTGAGGTGGAGGAAGGCCTTGGTATCGTTGAACGTATACAAAACTGCGATACAGACCGCAACGACCGTCCAACAGAAGATGTTAAGATAGAAACTGTAGCCTTATTGTAAGCCTACATAATGAAACATAAAATGACATAATATCCTTGTATAGTTATTCCAGCAAGAAATAACTATACAAGGATATCTTATTTAACCCAGCAGGTTTAATCTTTCTTAGCGAAGATAGTATGACAGAAGTTCCAAGTTCTTCTGCTTAGTAGCATCTACTATCAAGAAGATATCTATAAGCCACCAGATACCACAACCACCACCTGTCAACAACTTACCAATACCTAAACCAACATCACCAATATAAAAACGGTCAACACCGAGTGTCCCGATAAATATTGACAAAAGAATTGATAGCAAAGGATCTTTCATCTGAGACTGGAGAGCCAATATCTCTGACTCACTAATATCAGTGTTTTCCAATCTTGTACGAACACTCGGAATACTTCCTGCAGGGATTTTTGATGAAAGCATCATCAACATATGATTCACCTTTTCTGATTCCATAATGATTATCTTAGGTTTAATAATTTACATAACTTCACATGCTCTCAAAACCCATATCCACTATATCTTTAGGATGTTTCTTACAATAAACCAAATGAAAAAGAGGATTATATACAACCATATAAGCCGCTTATCTTCTATTACCTTTGTGAGACTATCCTTAGCCTTCCCTTTTGGAAGTAAGGCACGTACTCCAAACGATAATATGTATGGTCCAGAAAATAGAAGAAAATAATTATAGTGAATTGCTTCTGAAAACCGCCCTTGCAATAAAGCATGCAACGCACGTTGAATGCCACAACCAGGACATTGTAACCCTGTTGCGACCTTAAGGAGACATTTAGGTGCCCATAAAGTCGTAACAGGGTTATAGAAATAATACAGAATTAATAGGGAGGCTCCCAAACAGAGCCAACCTATACACTTTATAGTACGTTTCAAGGATTTAGTGAGATCCAGCCATTGTGCTCAATGCAGCCAAACCACCGAAGCAAACAAAATAAAGGATAGAACCAATTAGACCCACAACAATACCAATAATACTCCACTTTTTAGCGTCATTAGCAGCTAAAACAGCTTCATCGTATTGTTTCATCATATAAAGCTCATTCACCTTCATAGCGCGAATGATTGCATAAATACCTGCTGGCAAGCAGCAACATACAGTTGTGAAAATCGCAAGAGCCAAATTGTTATTTGGCTTAGGAGTGTTCATTTCTTCCATAACTTTTTTTGAGCCGACTCCCCATGGCATTCTTTTTTTGTTTTATTATTTGAACCACGTTGCTACTATGGTGGGGAAGTCTTAAGTGACACCTCTTCACAAACAGGTTATTGTTTTCAGCTATTACTTAACCGAGGACAAATTTAAGTAATTTAGATTAAATATACAAGCTAAAGAAAAACTTTTCTTTCTATCATAAACAAAAAAATTACATTTTAAACAAATATAACATTTACAAATAAACCAAGAAAAGCGAGTAAACCTATATTAGTTCATCTATCCACAAATACATCAGGGATTCTTTAACATGTTAAAACTATCACAAAACTTTATACATTCTTCCCTAAGTTCATAAACGAAGTCAAATAAACCGAGAAACTTCCATAAACAATAATCGGATTAAAGTCAATTGACTCTAACCCGATTCTTTTTTATATTCTCTCAATTATTCTTCTTAACTACATGCGAATCGTGCAAGAATAAGTCTGTTTCTGATTTATGCCAAACAGTTTACACGACCTATATTGTATTCACGAATGACATTTGTCATATAATGAAACATCTTACGCATAACACTCATATTCTTTACTTTCTCTTTCATAACGTTTCCTTTCCTCTATTGAGTTATACAATCTTTTACCTATGTCCCTATTGAGACTGAAGCCCTTTCAGTGGCTACCTCTTTGTTATCCTATTGAGGTGCCGTTTGTGTTGTTTTGTGCTTGCAAAGTTAGTACACTTTCCAAAATCTCACAAAGGAAACTTACACTTTCACTTTGTTTTTCCATTAAATTTTGACCTGCGTCAATAAGATTGACACGTATCAATCCCGCTATTTGACATATATCAACCCATGCGTGCCTTTATATCAACATCCTCTAAACGAATATATTATAATAAAAAAGAAGACGGAAAGACAAGTATCACATTTTCTTTTCTTATCTTTGCACTATGAACACAAACGAAAATCATAGCTTTCGATTACCTGCAGAGTGGGAACCACAAAGCGGAGTTATACTGATATGGCCGCACGAAGATACTGATTGGCGTCCTTATCTTGAGGAGATTACTGAAGTTTATCTCCAGATGGCAGATGCTATTACCCGATACGAGGCATTGCTTATCACAGCACGTGAAACAGAAATGGTAAGTTCCTTACTGAAAGGAAGGCTGACAGAGGAACAGATGAAACGTGTAACGCTCTTTACTTGTGACAATAATGACACTTGGGCACGAGACGTTGCACCGATTTCGCTCATAGCAAACAAAGCATCGAAAGATAGTTTCCATCCCCTTCGTCTACTTGACTTCTGTTTCAATGGATGGGGTGAGAAGTTTGCAGCAGAAAAGGATAATAGAATCAATCGTCAGCTTCACGAGGCAGGACTCCTCCAAGGAGTATTAGAAAACCACAAGGATTTTGTATTGGAAGGTGGTTCGATAGAAAGCGATGGAAGCCATACACTCTTTACAACAACGAGTTGTCTGATGGCACCACATCGTAATCAACCTCTCACACAAGAGGATATAGACAAGCAATTACGCCTTTTCTTTCCAAATGTAGAGCGAGTTATATGGTTAGATTATGGTCAGTTAGCAGGTGATGATACAGACGGACATATTGATACTATCGTACGTATTGCACCAAATGACACCTTATTATATATAGGATGTGACGATAAGGAGGATGAGCATTATGAGGACTTCCAACTCTTAGAGGAACAGCTAAAACAGCTCCGCACACAGAAAGGTGAGCCTTATCGCCTACTTCGTCTCCCTATGCCTGATGCTATCTATGATGATGACGAGCGTTTGCCTGCAACACACGCAAACTTCCTTATCATCAATGGAGCTGTACTTGTTCCAACCTACAACCAACCCGAAAAGGACAAAGAAGCTTTGGACACAATTCAAGAAGCTTTCCCTGATCGTGAAATCATAGGTATTGACAGCCGTACTATTATCAGACAGCATGGTTCCATACACTGTCTGACAATGCAGCTACCAGCAAACGGATAAAACCACTCTTCGTTTGAGTTGGTAACAAATGGAATAGTAATAAAAGAATACAGAACAATAAACATAAACAGGGCTAACACCTTTATTATGAGAGAACTTAAAATAGGCTTTCTACAACAACATAATGTTGAGGATATCAAAAACAATATAGAGCGATTGGCTGAGGGAATTACAAACTTAGCACAACGTGGTGCGGAACTTGTTATCCTCCAAGAACTGCACAATTCACTTTATTTCTGTCAGACAGAAGATGTGAATAAGTTTGACTTGGCTGAGACTATACCGGGTCCCTCTACTGGCTTTTATGGTGAGTTGGCACGTGAACTGGGTATTGTCATTGTGACATCACTTTTTGAAAAACGTGCACCAGGACTTTATCATAACACAGCCGTAGTGATAGAGAAGGATGGTAGTATTGCTGGTAAATATCGCAAGATGCATATTCCAGATGACCCAGCTTACTATGAGAAGTTCTACTTCACACCAGGTGACCTCGGATTTCATCCAATTGATACAAGCGTAGGACGCCTTGGTGTACTTGTATGCTGGGATCAGTGGTATCCCGAAGCAGCCCGTCTAATGGCATTGCAAGGTGCAGATATGCTTATCTACCCTACAGCTATTGGCTACGAAAGTAGTGATACAGACGAGGAAAAACAGCGTCAGCGTGAAGCTTGGACAACAGTCATGCGTGGTCATGCCGTTGCTAACGGTTTGCCAGTAATCGCTGTAAACCGTGTCGGTCATGAACCCGACCCAAGCGAGCAAACTCAAGGTATTCAGTTCTGGGGAAGCAGTTTTGTTGCTGGACCACAGGGAGAACTACTCTATCGCGCTTGTGACAACGATGAGGACAGTGTTATTCTCAGCATCAACCTCGACCATAGCGAGAATGTACGCCGTTGGTGGCCTTTCTTGCGTGACAGAAGAATCGATGAGTATGGGGAGATAACTAAAAGGTTTATAGATTAAAACCTTCGCCTAACTCTTCCGAAGGAGGGGAAAAGCTCCACCACTCTCCAGAATCAACGGTCACTCACTGAAGGGAAGTAATGAGAGAGGGAGTCTTAACGGAATAAAAGATTCTCTCTTTATTAATAATTACAGCTTGATAGGACTTAAATAAGGTTCATCCGACATTTCGAGTGATGAACCATAAGCTCTTATATTCATATAGTTACGAAGTAATAGCCTCCACTAAAAGCCTATAAAAAGCCATTTTATAAAAACAAAAAATCATAATTCAAGCTTTTCTAAAGTCGACGTTGCCGAACTGCTGTGCGACATCGTTAAATCCTTTTATATAAAGCTGTTATTAATGGAGATATGATGCCATTTGCTCATTTGCATTTAATATCGGAGTTGGAAGAGGATTTCCTTCTTCCGAATTTTTGAAAGAACTAAATAAAGGGCACTATGATGGGACACTGATGCTCCATTGGAGACGTCCAAGCGAAATAATAGGGAGAAGGAAAAAAGAGGTTGAATTGTTTAATCATGGAGTATACTAGAAATGAGAATGAAAATGTTAATTTTAATTGGCTTCATCACCGTAAGTTGTACATCAGTACCTAACAAGAAGTGTATTGTACAAAAAAATCAAGTAAGAGTCATAAAAACAGAGAAATCTACAGCATTCAAGTATTTACAAGGTATTTGGATAATACCACATGCAGCTGATATACGAATTGTTTTCAAAAATGACTCTACTTTTGAGTTTCATGATTATAACTCAATCAAAGATTCTATAGAGATTTTAAAAGGTATATATGTATTAAATAATGATCAACTTACACTTAGATATACTGATAGACCTCAACAGAAGTTTATCTATCACTTTGGCAGATATGAGGACGAGCGTTATATTAGAAAAGGAAAGTACTATTTTGTAAAACAATAAGTCACGACTTGAGAGTGATTTAATCCCCCCCCTTTCGGGGCAGGGGTATTTGTGGTACAAATGGTAATTTGTGGTACAAAGACACACCTTGCCAGTATAAAGAAAGAGAAAGTTTGTTATGTTCCATAAAGTAACCTTTCTGGGGTGCTTTTAATAGACGAGAGTTCAAAGTTCAAAAAGTAAGTCAAGAGATAAGTTTGGGCCTTCAGTATTTTGGAGTGATAGTGTTTAATATCTGATTATCAATAACTTTTATAATTTAAACACTTTTATATCCCCTTTGTTTACTGATATTAAAGAATACAAAGTACTAATTTAAAGGTTACGAAAGTTGTTGTTGTATCACATGGGTTATACACGCTATAAAACGCTTATAATGAATTATTTACAAATCTTCTTTACTAACAAGTGGCATAAAGGAAATTATCGCATCACTCCAAATTTCGGAAGAGCCTTAAATAACATCTCCTTCCACACGGAATATGATAATAAGTAGAACTTATCTAACAAGATAGTGCGACTTAATATGCCATCCGCACCATTGGTGTTTACCATGAGCACCACACGTGCTGAGCATCAACACATAGGCTGGATATGGATTGAGAGTTGCAATTGTTATACAAAAAGAGCCATACCAAACTTATTTTTAGAGTTTGATATGGCTCTTTTTTAGTTCTATAAATATAATATGTAAGCTTCTAAATCAACGGCATTCCTGCCTCTTCGCACTCTCTTCTCATTTCTTCTGGCCAGATACTTGCTTGTATCTCACCAATATGCGCCTTGTGCAACATTATCATACAAAGACGGCTCTGTCCGATACCGCCACCAATACATAACGGCAGTTTGTCTGAGAGTAACTGCTGATGGAAGAAGAGTTGCTGACGTTCTTCTTGCTTCTCTATCGTCAACTGACGGAGTAAGGCAGTCTTATCCACACGGACACCCATAGACGAAAGTTCTATACTACGATCTAAGATAGGGTACCAAATGAGAATATCACCATTCAAGCCAGTCTTACCATCTTCTGCAACAGTTGACCAGTCATCATAATCAGCAGCACGTCCATCGTGCTTCTCACCATTACTTAATCTACAACCAATACCCTCAATAAACACCGCACCATACTTCTTACAAACCTCATCTTCACGTTCTTTTGCTGTCATTGTAGGATACATATCCAACAAATCTTGCGCATGAATAAAATGAATTGTCTGTGGAAGGAAGGGTTCTAACTGAGGATAGGTCTCACAAGTAAGGAACTCTGTACGAAGGATAGCAGCATAAATACGACGAACGACATTCTCTAAAAAGCTACGTGTTCTATCGCCTTCGGTGATAACCGCCTCCCAATCCCATTGGTCAACATAAAGTGAATGAAGGTTGTCTAATTCTTCATCGGCTCGAATAGCATTCATATCTGTATAGACACCATAGCCCGGTTGAATGTCATAGTCAGCCAACGTCAGTCGTTTCCACTTTGCCAGAGAGTGTACTACCTCAGCCTCAGCTTCTCCCAAGTCCTTAATCGGAAAGGAAACAGGACGTTCAACACCATTCAAGTCATCATTGATACCTAATCCTTTCAACACGAACAACGGTGCTGTAACACGACTTAGTCGTAATTCGGTAGCTAAGTTCTGCTGAAAAAACTCCTTTATAAGTTTGATACCCTGCTCGGTTTGACGTTTGCCAAGTACTGCTTTATATCCTTCTGGCTTTATCAGTTGACTCAT

Protein sequences of DBSCAN-SWA_2

>CP022040|1273406:1281876|1274303_1275050_+|ASE17514.1|DBSCAN-SWA
MATRLKIKTTEGDIIIRLYDETPKHRDNFLKLAKEGYFNGTLFHRVIKDFMIQGGDPDSKNAPKGKMLGTGGPDYTIPAEFVYPQYFHKRGALSAARTGDEVNPEKESSGSQFYIVWGKTFKPAELKQMEHQMAMQQEQQVFNQLTREHHEEIMNLRRNRDRVGLQELQDKLIEQTKTTCKQQGKPSFTEEQIEVYTNVGGTPFLDNQYTVFGEVEEGLGIVERIQNCDTDRNDRPTEDVKIETVALL
>CP022040|1273406:1281876|1275942_1276221_-|ASE17516.1|DBSCAN-SWA
MEEMNTPKPNNNLALAIFTTVCCCLPAGIYAIIRAMKVNELYMMKQYDEAVLAANDAKKWSIIGIVVGLIGSILYFVCFGGLAALSTMAGSH
>CP022040|1273406:1281876|1275557_1275926_-|ASE17937.1|DBSCAN-SWA
MKCIGWLCLGASLLILYYFYNPVTTLWAPKCLLKVATGLQCPGCGIQRALHALLQGRFSEAIHYNYFLLFSGPYILSFGVRALLPKGKAKDSLTKVIEDKRLIWLYIILFFIWFIVRNILKI
>CP022040|1273406:1281876|1273406_1274216_+|ASE17513.1|DBSCAN-SWA
MAIGKWIGGALGWILSGSMLGGLVGYCIGTMLDEAFAGDNRGGDRQNGYGEQSHFGGTRPFEEDRNSFLFSMLVLSSYIIKADGKIMHSEMEYVRQFLRHNFGEQAVSQGESILLKLFDLQKQQGPYQFKETIRKSCVEIHFHTSVSQRLQLLNYLVIIAKADGIVSPEEVVALKEIASYLGLSAQDIESMLNLESGAKASSNIEDAYKVLGISPSATDDEVKAAYRKMALKHHPDRVSTLGDDIRKAAEKKFQEINDAKERIYKARGL
>CP022040|1273406:1281876|1275155_1275497_-|ASE17515.1|DBSCAN-SWA
MESEKVNHMLMMLSSKIPAGSIPSVRTRLENTDISESEILALQSQMKDPLLSILLSIFIGTLGVDRFYIGDVGLGIGKLLTGGGCGIWWLIDIFLIVDATKQKNLELLSYYLR
>CP022040|1273406:1281876|1277172_1278240_+|ASE17517.1|DBSCAN-SWA
MNTNENHSFRLPAEWEPQSGVILIWPHEDTDWRPYLEEITEVYLQMADAITRYEALLITARETEMVSSLLKGRLTEEQMKRVTLFTCDNNDTWARDVAPISLIANKASKDSFHPLRLLDFCFNGWGEKFAAEKDNRINRQLHEAGLLQGVLENHKDFVLEGGSIESDGSHTLFTTTSCLMAPHRNQPLTQEDIDKQLRLFFPNVERVIWLDYGQLAGDDTDGHIDTIVRIAPNDTLLYIGCDDKEDEHYEDFQLLEEQLKQLRTQKGEPYRLLRLPMPDAIYDDDERLPATHANFLIINGAVLVPTYNQPEKDKEALDTIQEAFPDREIIGIDSRTIIRQHGSIHCLTMQLPANG
>CP022040|1273406:1281876|1279753_1280140_+|ASE17519.1|DBSCAN-SWA
MRMKMLILIGFITVSCTSVPNKKCIVQKNQVRVIKTEKSTAFKYLQGIWIIPHAADIRIVFKNDSTFEFHDYNSIKDSIEILKGIYVLNNDQLTLRYTDRPQQKFIYHFGRYEDERYIRKGKYYFVKQ
>CP022040|1273406:1281876|1278327_1279212_+|ASE17518.1|DBSCAN-SWA
MRELKIGFLQQHNVEDIKNNIERLAEGITNLAQRGAELVILQELHNSLYFCQTEDVNKFDLAETIPGPSTGFYGELARELGIVIVTSLFEKRAPGLYHNTAVVIEKDGSIAGKYRKMHIPDDPAYYEKFYFTPGDLGFHPIDTSVGRLGVLVCWDQWYPEAARLMALQGADMLIYPTAIGYESSDTDEEKQRQREAWTTVMRGHAVANGLPVIAVNRVGHEPDPSEQTQGIQFWGSSFVAGPQGELLYRACDNDEDSVILSINLDHSENVRRWWPFLRDRRIDEYGEITKRFID
>CP022040|1273406:1281876|1280838_1281876_-|ASE17520.1|DBSCAN-SWA
MSQLIKPEGYKAVLGKRQTEQGIKLIKEFFQQNLATELRLSRVTAPLFVLKGLGINDDLNGVERPVSFPIKDLGEAEAEVVHSLAKWKRLTLADYDIQPGYGVYTDMNAIRADEELDNLHSLYVDQWDWEAVITEGDRTRSFLENVVRRIYAAILRTEFLTCETYPQLEPFLPQTIHFIHAQDLLDMYPTMTAKEREDEVCKKYGAVFIEGIGCRLSNGEKHDGRAADYDDWSTVAEDGKTGLNGDILIWYPILDRSIELSSMGVRVDKTALLRQLTIEKQEERQQLFFHQQLLSDKLPLCIGGGIGQSRLCMIMLHKAHIGEIQASIWPEEMRRECEEAGMPLI

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
ASE17513.1|1273406_1274216_+	molecular chaperone DjlA	A0A1V0SBY2	Catovirus	1.4e-05	51.8
ASE17514.1|1274303_1275050_+	peptidylprolyl isomerase	A0A076FI46	Aureococcus_anophage	1.3e-05	32.4
ASE17515.1|1275155_1275497_-	TM2 domain-containing protein	A0A1B0T6B3	Bacillus_phage	1.4e-07	50.8
ASE17937.1|1275557_1275926_-	DUF2752 domain-containing protein	NA	NA	NA	NA
ASE17516.1|1275942_1276221_-	hypothetical protein	NA	NA	NA	NA
ASE17517.1|1277172_1278240_+	agmatine deiminase family protein	M1I5R4	Acanthocystis_turfacea_Chlorella_virus	2.8e-43	29.3
ASE17518.1|1278327_1279212_+	acyltransferase	M1H5W0	Paramecium_bursaria_Chlorella_virus	5.4e-56	38.8
ASE17519.1|1279753_1280140_+	hypothetical protein	NA	NA	NA	NA
ASE17520.1|1280838_1281876_-	aspartate--ammonia ligase	A0A1C9C5F0	Heterosigma_akashiwo_virus	3.8e-53	38.8