CRISPRimmunity

Please click to download your results

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
CP025491	Legionella sainthelensi strain LA01-117 chromosome, complete genome	2 crisprs	cas3,WYL,DinG,DEDDh,csa3,RT	1	3
CP025492	Legionella sainthelensi strain LA01-117 plasmid pLA01-117_150k, complete sequence	0 crisprs	DinG,WYL	0	0
CP025493	Legionella sainthelensi strain LA01-117 plasmid pLA01-117_113k, complete sequence	0 crisprs	DEDDh,DinG	0	1

Results visualization

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Crispr_ID: CP025491_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP025491_1

1396183-1396300

Orphan

Consensus_repeat	Method
GCCAATTCTGCGCCTGATATTTCGCCAAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP025491_1

>merge|CP025491|1|1396183-1396300|CRISPRCasFinder
GCCAATTCTGCGCCTGATATTTCGCCAAGCGAATTCCTGCTTAAATCAAGCGTGGTTATCTCTTGTGGCATGGTAGCAAAAGCTTGAGCCAATTCTGCTCCTGATATTTCGCCAAGCG

>CP025491|1|1|1396183-1396300|CRISPRCasFinder
GCCAATTCTGCGCCTGATATTTCGCCAAGCG	AATTCCTGCTTAAATCAAGCGTGGTTATCTCTTGTGGCATGGTAGCAAAAGCTTGA
GCCAATTCTGCTCCTGATATTTCGCCAAGCG

Protein	Signature genes	Signature genes Name	Protein_function
CP025491.2\|AUH72808.1\|1394177_1394396_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|315923
CP025491.2\|AUH72806.1\|1393463_1393913_-\|LuxR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|99777
CP025491.2\|AUH73985.1\|1397686_1397941_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl\|CDD\|374105
CP025491.2\|AUH72807.1\|1393988_1394177_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|315923
CP025491.2\|AUH72818.1\|1407845_1408352_+\|DNA-polymerase-V	unknown	unknown	gnl\|CDD\|182350
CP025491.2\|AUH72809.1\|1394532_1395015_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379267
CP025491.2\|AUH72810.1\|1396680_1396863_-\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH72811.1\|1397442_1397670_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|314732
CP025491.2\|AUH72804.1\|1391869_1392202_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
CP025491.2\|AUH72805.1\|1392201_1393467_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340927
CP025491.2\|AUH72814.1\|1404614_1405055_-\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH72816.1\|1406046_1406226_+\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH72812.2\|1399308_1401279_-\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH72802.1\|1390413_1390794_-\|DUF4949-domain-containing-protein	unknown	unknown	gnl\|CDD\|292923
CP025491.2\|AUH72815.1\|1405475_1405661_+\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH72817.1\|1407040_1407709_+\|SOS-response-associated-peptidase	unknown	unknown	gnl\|CDD\|376837
CP025491.2\|AUH72813.1\|1401949_1403368_-\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH72801.1\|1389834_1390368_-\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH72803.1\|1391418_1391787_-\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH72800.1\|1388681_1388939_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|379165

Protein	Function_ID	Function_description	E-value
CP025491.2\|AUH72808.1\|1394177_1394396_-\|hypothetical-protein	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	4.44574e-11
CP025491.2\|AUH72806.1\|1393463_1393913_-\|LuxR-family-transcriptional-regulator	gnl\|CDD\|99777	cd06170, LuxR_C_like, C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.	5.46966e-10
CP025491.2\|AUH73985.1\|1397686_1397941_+\|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl\|CDD\|374105	pfam15781, ParE-like_toxin, ParE-like toxin of type II bacterial toxin-antitoxin system.	1.57059e-34
CP025491.2\|AUH72807.1\|1393988_1394177_-\|hypothetical-protein	gnl\|CDD\|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.3449e-07
CP025491.2\|AUH72809.1\|1394532_1395015_-\|hypothetical-protein	gnl\|CDD\|379267	pfam13565, HTH_32, Homeodomain-like domain.	7.15462e-07
CP025491.2\|AUH72804.1\|1391869_1392202_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	2.56472e-12
CP025491.2\|AUH72805.1\|1392201_1393467_-\|MFS-transporter	gnl\|CDD\|340927	cd17369, MFS_ShiA_like, Shikimate transporter and similar proteins of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.80025e-81
CP025491.2\|AUH72818.1\|1407845_1408352_+\|DNA-polymerase-V	gnl\|CDD\|182350	PRK10276, PRK10276, translesion error-prone DNA polymerase V autoproteolytic subunit.	1.60159e-44
CP025491.2\|AUH72802.1\|1390413_1390794_-\|DUF4949-domain-containing-protein	gnl\|CDD\|292923	pfam16307, DUF4949, Domain of unknown function (DUF4949). This small family consists of uncharacterized proteins around 140 residues in length and is mainly found in various Legionella pneumophila and longbeachae species. The function of this family is unknown.	1.10812e-24
CP025491.2\|AUH72817.1\|1407040_1407709_+\|SOS-response-associated-peptidase	gnl\|CDD\|376837	pfam02586, SRAP, SOS response associated peptidase (SRAP). The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.	1.066e-102
CP025491.2\|AUH72811.1\|1397442_1397670_+\|hypothetical-protein	gnl\|CDD\|314732	pfam11903, ParD_like, ParD-like antitoxin of type II bacterial toxin-antitoxin system. ParD-like antitoxin is a family of archaeal and bacterial proteins of a type II bacterial toxin-antitoxin system. Many of the cognate toxins for these molecules fall into family ParE-like_toxin, pfam15781. Gene-pairs are expressed from the same operon, the toxin of the pair being expressed first, eg, for UniProtKB:Q3AQ93 and UniProtKB:Q3AQ94.	5.99202e-17
CP025491.2\|AUH72800.1\|1388681_1388939_+\|ATP-binding-protein	gnl\|CDD\|379165	pfam13401, AAA_22, AAA domain.	2.22573e-10

>CP025491.2|AUH72809.1|1394532_1395015_-|hypothetical-protein
MIRIYLNEAAKIDLIRLSRSQKSNIGERAYYVLLCGEGHSVSETAKITGRNEHTIRLWLKRYITCGITGLKSRSQPGRPARKAPIIESQLEESLGKSPQEYGYQEAGWQINLLRDWFEKQGMTACDNTLVKSLNRLVLCINDFQKSYQQMHHPRLRKNHG
>CP025491.2|AUH72808.1|1394177_1394396_-|hypothetical-protein
MKARLSKTIFGALNMRTSRFYWKQADTGNSQQFIMFLHQFHKANPNKKLMIILDNRPIHKSKKVQKFVRKND
>CP025491.2|AUH72807.1|1393988_1394177_-|hypothetical-protein
MNLFFLPAYSSEYNPIERFWQWLKQRVYGCKSFSTMEELLQQIRKLVWHFREGRTVSKINFN
>CP025491.2|AUH72806.1|1393463_1393913_-|LuxR-family-transcriptional-regulator
MNNAFGFYREYDGYKFMCVFARKKESVAPKLNFSAEKSMMNIVWKFLNQILPYYQQENSALKYSRISQDASFRKNFIFGQYKSSFLELKDRERGCLFWARYGKSTSETSKILGLKRATVKKYLEGVREKCQVSSIQEAITLALQHQFIS
>CP025491.2|AUH72805.1|1392201_1393467_-|MFS-transporter
MSYHMENKKKRVTVASIGTFLEWAEFTYFAYIANIIAALFFPELSSRLGLIATFSVFAVGYFFRPLGSLYFGYLGDKLGRRVALQASIMLMGISSLLIGCLPTYNTIGILAPTLLVLLRCTQGFAVSGEFNGSAIYLIEHDVEKPCQAGSWTGFASALGMMFGGLMATLISYHQMPVWAWRIPFLFGTLSCFCALYFRRNLSESPAFLSMTKERSVNPLKILFKNYKNKLLKAASLIAALSIYIYIMNVFYATHLAKYTTLQATETKLIVTFAQGLVALFIFSIGILADKINEQRLITMGFIGYFIAAPLAYWVPQTNSFILILLAQIPYALCNALVGVPIFKILNDFFPTQIRYSGVSIAWGVSTAIFGGTAPLVAVYLQNLFNLSIAPIFYILLSATIALLVLQNKKRYKVTSMKLELR
>CP025491.2|AUH72804.1|1391869_1392202_-|class-I-SAM-dependent-methyltransferase
MTIVERRGLWNPEHYFKNSATQFGHATELLKNYPFKGDELILDVGCGDGKITVALANLVPNGQVIGLDKNSTTINFAQEKFPSNSYPNLSFLHGDVTHPSNLGKFSNRFI
>CP025491.2|AUH72803.1|1391418_1391787_-|hypothetical-protein
MLYRKCKAQWDALNKTSAHTKWSHYFKNYDPGYYEYLPTSYQELLNASGLGRFKAEFTTEEQISYEDIETFTNFMKGWLPHLNILPKEHHDEFLSLFITDYLNNLNTSISKITIPFVRLIIA
>CP025491.2|AUH72802.1|1390413_1390794_-|DUF4949-domain-containing-protein
MKFRAKLFSFTLASILTGSVFSVQFECPKIEVIKTEDFLFAEKIKENFYLTYNISKFETDSYWVFVLRPIEAETANKAKHRANEVLSKMYEQGVFMEEDGESFCQYPTGDNTLLARAAPENLLSTM
>CP025491.2|AUH72801.1|1389834_1390368_-|hypothetical-protein
MKQSIKFEMSLPDSSFSLYLRQLHEESNRLVVILEVVESDVGFSFSMVQDMFLNLIIYTKCNHELPVICFVIQDTEPNYWLEKVNHVRSNKEIILSADAICIYNGELKVPKQFMMVPKYYEIHNGQAIETTINSPQETKVSNTGMFSSSKNDTDDTKNGKDDTVEADKSYFSQCTII
>CP025491.2|AUH72800.1|1388681_1388939_+|ATP-binding-protein
MLLSLAQDEGFIKIVGEVGTGKTLLCRILLNQLAEDYVTVYIPNPDQTAKSMRFAIASELGIPAETHWNQHQTLEAIKLRLLELT
>CP025491.2|AUH72810.1|1396680_1396863_-|hypothetical-protein
MFLIFQAMIIMSAKPIKHDACSKIYVQIMNERFNVKVWPIINTFYDIISAHDLRDLFKLS
>CP025491.2|AUH72811.1|1397442_1397670_+|hypothetical-protein
MGIPIRIDETIYYEAKKVAAAEFRSIPNQIEYWAKLGKCALDNPDLPIEFIKDVLLSKLQDKSLAEPFQFEGEGG
>CP025491.2|AUH73985.1|1397686_1397941_+|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MPAFKKAYKKLPSSHKSIINEAVRIIVNNPKVGEEKKGDLAGVYVYKFKMNHQQFLLAYEWEPTLRILVALGVHENFYRDLKRK
>CP025491.2|AUH72812.2|1399308_1401279_-|hypothetical-protein
MLPLFPKEDQPITIEQGRVGDCYLLAAIDCLYNSKDGKKRLTNMFTELSNGDIEVRIQYSKQSQYLKPEKVKLKYQYKNNIENDIITIPKDRLELIAKDQRGVKTNSLAVLILEHLSPYFFTVAREDSLLAHNHIIRYEGTDADFIAKLVGFEAGYLEDINQVIKLKTIAPHEPVYFTLDYGQQDRRGVYHSRHALRVDKITPNPQIPGGYEFSLVNPWNTRIIETWSQEDIKKRRPKYACFYKNKEKKAFSLKILSIAEHEAGFIFNHSELKENLFSLFRTRNDVNTQFLLNGVSLYKRFPSIFDKIPSIASRELSIFNSSIQKDALIACLKSSPEQFENNYKLLIKKCFPNTDFASQEEVNKLTDLINQNVRRQSGAPIEKPEEKIMDFYFFQDFEKLPPGNIRNTFIHPETIAAVPQLKKKLLARGLHLLAINDIGQFGVDGKDFLKSEHPVDQQLYKDIRAQEKNFLNPLKSIFNVRSINPSLSKQLLKLAKEDLAKTNVKTIKTMIDKQPDDAFKAWLKSMFDSDIELRTKWNNNLALEIRALLKDPSQLSSLPAFFEKINNDDFINKYIKVYEKHFGIVPKKEIGDIVLNEWQRKMNNERHQRKKPLGESTPNDAPVRNLNLLFKPFPQPSFNKDLNNDNEETYRKNPLA
>CP025491.2|AUH72813.1|1401949_1403368_-|hypothetical-protein
MSYSNLETVRSTNLTTLNVWLCNDGDFNTDIQKAEKYLQNMGNFILSSVDFTPLEFAEKMEVKLKRILGQADNTIQEEKLNDCINKIENYKKFLKLNLPAAEKKANNLIKQYKNVTDIKEECLNEMLRAKPKLHRARNLFIKVAQQADKSIFQRGINSYQILWDQLSTNLKIFKDIVKKYPENQLALLLHDPQSFIEALEDGKIPLGGELGALALQRIFSEYPQLTVRQKVSIATLIEKTQIERDTHCNSVALKSEIIKLQLYAQYCRDNDLPLVAWIGSARPVFSMIADHPGEGAYLNCDDAKWSPELNSTWLLIVSSMGYEIKLVEQHYPKVVDALTSGNILNYVSALIDEIRPFRKEFDSQYHGGDQPTATPQEILRLMSIGCKAKKNDDGSVSLTPPKSWVAEDYRSRKIKGLPQKDNIGRESQDVGVSRTRRHSVAFFKGSAQPVKKSLFEHPGESEEIRKNEKPKL
>CP025491.2|AUH72814.1|1404614_1405055_-|hypothetical-protein
MAKIFWGISFLSTLGAILYYNLFTPNSAPQQAALAAMTLVIAILPYCLARAVAEAEKIAEVKEKTELHKEINSTFLDYFILNRISLLFTLTNVEHLSTPTYEQIINRVNYLKKLLDEDLISNDEYEQARNYLLVTLKDNLKQQIER
>CP025491.2|AUH72815.1|1405475_1405661_+|hypothetical-protein
MDLPFYFERQRKGGKLYLNLHHQNKRYRKRYGSPKRTGPIKNCRLNLCRCQAFKIIQNLNE
>CP025491.2|AUH72816.1|1406046_1406226_+|hypothetical-protein
MKKPGSIADKSGQYEIVGPRGGKTGEERTVTKGEPLPPTPKPGQGYILVDSSKNKSGKK
>CP025491.2|AUH72817.1|1407040_1407709_+|SOS-response-associated-peptidase
MCGRFSYIASYETLKYQFNSTNSVEITPKFNIAPGTDVLCLIKTNSNEVQSVLLHWGLIPSWATDRKKIGSLINARAETLFEKPAFRNAMKSKRCLMPMSGFYEWHMESGVKQPYFFRLKNQELLAVAALWDTWQSATEVIHSCCLITTEANSVMQSVHHRMPVILDKEGQSLWLDNSQCPKEELLALLKPYSNEDLQGYRVSTLVNNADFEHPLVIEPLPQ
>CP025491.2|AUH72818.1|1407845_1408352_+|DNA-polymerase-V
MSPRGGTRPGAGRPKGEPTKTVRLPVSLLAELEQLKERPNYQLPIFSSKVQAGFPSPADDYIEGYLDLNTKFIKHPSATFVLQVMGDSMVEAGIFSGDWLLVDRSIEATDGRIVIAAVNGELTVKRLSKKEGKIQLLPANPKFKPIDITQDCEMVVWGVVTLVLHELV

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: CP025491_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP025491_2

3029564-3029732

Orphan

Consensus_repeat	Method
TCAAATTTACCGCGATAACAGTAATTT	CRISPRCasFinder

2 spacers

The CRISPR arrays of CP025491_2

>merge|CP025491|2|3029564-3029732|CRISPRCasFinder
TCAAATTTACCGCGATAACAGTAATTTTTAGGAATTTATAATAAATAAATATGGGAAAATCAGGAAATCAATCAAATTTACCGCCATAACAGTAATTTATGGTGAATTAATGCAAAGAAATACAATAATAAATTTATTTTTATCATTTTTACTGCTATAACAGTAATAT

>CP025491|2|2|3029564-3029732|CRISPRCasFinder
TCAAATTTACCGCGATAACAGTAATTT	TTAGGAATTTATAATAAATAAATATGGGAAAATCAGGAAATCAA
TCAAATTTACCGCCATAACAGTAATTT	ATGGTGAATTAATGCAAAGAAATACAATAATAAATTTATTTTTA
TCATTTTTACTGCTATAACAGTAATAT

Protein	Signature genes	Signature genes Name	Protein_function
CP025491.2\|AUH70823.1\|3031916_3033647_+\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH70824.1\|3038871_3040131_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|237999
CP025491.2\|AUH70819.1\|3028657_3029365_+\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH73882.1\|3035464_3037135_+\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH70825.1\|3040466_3040694_+\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AYK03072.1\|3033913_3035284_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225180
CP025491.2\|AUH70822.1\|3030282_3031221_+\|type-II-toxin-antitoxin-system-HipA-family-toxin	unknown	unknown	gnl\|CDD\|377920
CP025491.2\|AUH70811.1\|3019041_3019254_+\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH70821.1\|3029977_3030286_+\|toxin-HipA	unknown	unknown	gnl\|CDD\|274416
CP025491.2\|AUH70818.1\|3027109_3028621_+\|Fic-family-protein	unknown	unknown	gnl\|CDD\|225718
CP025491.2\|AUH70816.1\|3025417_3025645_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|213767
CP025491.2\|AUH70817.1\|3025631_3026852_+\|type-II-toxin-antitoxin-system-HipA-family-toxin	unknown	unknown	gnl\|CDD\|341492
CP025491.2\|AUH70813.2\|3020129_3020897_+\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH70812.1\|3019307_3019883_+\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AUH70826.1\|3040985_3041477_+\|Hsp20/alpha-crystallin-family-protein	unknown	unknown	gnl\|CDD\|223149
CP025491.2\|AUH73883.1\|3037198_3038800_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369446
CP025491.2\|AUH70814.1\|3021090_3021618_-\|hypothetical-protein	unknown	unknown	unknown
CP025491.2\|AYK03071.1\|3021995_3022361_-\|conjugal-transfer-protein-TraK	unknown	unknown	gnl\|CDD\|379959
CP025491.2\|AUH70815.1\|3024497_3024773_-\|DNA-binding-protein	unknown	unknown	gnl\|CDD\|378935
CP025491.2\|AUH70820.1\|3029753_3029981_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|213767

Protein	Function_ID	Function_description	E-value
CP025491.2\|AUH70820.1\|3029753_3029981_+\|transcriptional-regulator	gnl\|CDD\|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	2.15563e-23
CP025491.2\|AYK03072.1\|3033913_3035284_-\|MFS-transporter	gnl\|CDD\|225180	COG2271, UhpC, Sugar phosphate permease [Carbohydrate transport and metabolism].	0
CP025491.2\|AUH70822.1\|3030282_3031221_+\|type-II-toxin-antitoxin-system-HipA-family-toxin	gnl\|CDD\|377920	pfam07804, HipA_C, HipA-like C-terminal domain. The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.	1.23781e-59
CP025491.2\|AUH70821.1\|3029977_3030286_+\|toxin-HipA	gnl\|CDD\|274416	TIGR03071, couple_hipA, HipA N-terminal domain. Although Pfam models pfam07805 and pfam07804 currently are called HipA-like N-terminal domain and HipA-like C-terminal domain, respectively, those models hit the central and C-terminal regions of E. coli HipA but not the N-terminal region. This model hits the N-terminal region of HipA and its homologs, and also identifies proteins that lack match regions for pfam07804 and pfam07805.	2.4741e-44
CP025491.2\|AUH70818.1\|3027109_3028621_+\|Fic-family-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	6.23465e-17
CP025491.2\|AUH70816.1\|3025417_3025645_+\|transcriptional-regulator	gnl\|CDD\|213767	TIGR03070, couple_hipB, transcriptional regulator, y4mF family. Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions].	5.4072e-19
CP025491.2\|AUH70817.1\|3025631_3026852_+\|type-II-toxin-antitoxin-system-HipA-family-toxin	gnl\|CDD\|341492	cd17793, HipA, type II toxin-antitoxin sytem toxin HipA and similar proteins. This family contains type II toxin-antitoxin (TA) system HipA family toxins similar to Escherichia coli and Shewanella oneidensis HipA, which is a serine/threonine-protein kinase that phosphorylates Glu-tRNA-ligase (GltX), preventing it from being charged, leading to an increase in uncharged tRNA(Glu). This induces amino acid starvation and the stringent response via RelA/SpoT and increased (p)ppGpp levels, which inhibits replication, transcription, translation and cell wall synthesis, reducing growth and leading to persistence and multidrug resistance. HipA is the toxin component of the HipA-HipB TA module that is a major factor in persistence and bioflim formation; its toxic effect is neutralized by its cognate antitoxin HipB. HipA, with HipB, acts as a a corepressor for transcription of the hipBA promoter. Structures of HipAB:DNA complexes from both Escherichia coli and Shewanella oneidensis reveal distinct complex assembly.	1.21949e-158
CP025491.2\|AUH73883.1\|3037198_3038800_+\|hypothetical-protein	gnl\|CDD\|369446	pfam07642, BBP2, Putative beta-barrel porin-2, OmpL-like. bbp2. BBP2 is a family of putative porin proteins that are likely to be outer membrane beta barrel proteins porins.	4.29939e-10
CP025491.2\|AUH70826.1\|3040985_3041477_+\|Hsp20/alpha-crystallin-family-protein	gnl\|CDD\|223149	COG0071, IbpA, Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones].	1.96249e-31
CP025491.2\|AYK03071.1\|3021995_3022361_-\|conjugal-transfer-protein-TraK	gnl\|CDD\|379959	pfam17273, DUF5338, Family of unknown function (DUF5338). This is a family of unknown function which can be found mostly in Proteobacteria.	3.18334e-24
CP025491.2\|AUH70815.1\|3024497_3024773_-\|DNA-binding-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	0.00250657
CP025491.2\|AUH70824.1\|3038871_3040131_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	1.55608e-19

>CP025491.2|AUH70819.1|3028657_3029365_+|hypothetical-protein
MEFAKPVKVAFGRLEHIAFIKRHLDVYKKPDITQYPIAAYEFDFLDFIYSLGLINILTFVCISLFPSYFKYDPFKIFNIIPIMLLLIANTVLIAAVIVLFHWGLCKCIGFIYKIKTHTFYEAGIFWRVFRVLSLSYLLITIPLLIQINSIFTHEGLGTTLNLISLLTIILMLMLQIKLFILPLYKIGKQFGKALGSIQSLLVIASALLINNFFWKQIPPSIFVNIQEVIKLFSAQ
>CP025491.2|AUH70818.1|3027109_3028621_+|Fic-family-protein
MKPSEKLAQSLEVLHNLQKQGKYAIQSKDISRTHRERLIENAFLEEVVKGWYVPIKPDEQKGESTAWYASFWSFCASYLNERFGDEWCLSPEQSLLLHSENWTVPKQLMIRSPKGTNRNMELPHNTSLFSVQYKMPATQDIEIKQDIRVYSIVPALLYCSPKFFSQYPTEARSVLSMFNSASDLLHYLLEEGHSWIAGRICGALQNIGKSHVAEEIKKTMESAGYQIREEDPFLTNTPIDFSVIYKPAYRSRLEVMWHDMRNIVRENFPKPRPTTIDIKGYLEQVDENYVSDAYHSLSIEGYQVSPDLIQKVRFGQWDPDATKQDRNHRSALAARGYWQAFQAVKKSLIEILNGENPGKVIQKEHRDWYRELFQPGVAVGLLKPTDLAGYRRSPVFIRQSKHIPPRWQIVGELMEEFFQLIIQEKEPGVRVVLGHFFFVYIHPYSDGNGRIGRFLMNVMLASGHYPWTIIPVERRNEYMEALEQASADQNIIPFTKFIASCIE
>CP025491.2|AUH70817.1|3025631_3026852_+|type-II-toxin-antitoxin-system-HipA-family-toxin
MKNHKLGVYLNQILAGQLSIDTRGDMSFEYDNYYLENKQNRPLSHSLPLQKASYSTKQCRPFFSGLLPEAHMRTAIARQLGISEKNDFALLAAIGGECAGAVMILPQNTSIAQLKPDYKIIKKKDVLEILQTMHQRPMIVGEDGVRLSLAGAQDKLPVAIIEENLAIPMNGAPSTHILKPINRDFPTLIENECFCLNLAQKIGLNAVDAAIHYADDTPYLLVKRYDRVETEQGIQRLHQEDFCQALGISPEMKYQREGGPKISECFGLIREISSLPIFDIKELLQGILFNVIIGNNDAHSKNFSLLYHGSKTRLAPFYDMISTIYYPNLSSKMAMKVGSKYDFDGLFPRHFTQMAEEALLSGALVRKEVLDLVSKIQKNITASPFTGIILQRADKLFQRFQKSSAE
>CP025491.2|AUH70816.1|3025417_3025645_+|transcriptional-regulator
MIQSPEKIGCYIRKVRKELNVTQKDLALTAGTGLRFIIDLENGKPTCQIGKILQVLQVLGIQLNLSHADFENEKS
>CP025491.2|AUH70815.1|3024497_3024773_-|DNA-binding-protein
MTLKKLSRLNLLNEFESAPHSALFNQQTIAAVLSCSTQLLERNRWAGGGVPYLKIGRKVLYRKSDVLNFLQQQKIYYSTSDEGQIQPVENA
>CP025491.2|AYK03071.1|3021995_3022361_-|conjugal-transfer-protein-TraK
MKKSLTENLMISKHSQQITNSRKNKVAFLAMREDISEALEKGWSITVIWKTLRDEGSFTATYNTFRLYVLKYLNGQKSGYSQMEAIEQRTTKPVESQTKEKKPTAISSFSFNPIPNLKELL
>CP025491.2|AUH70814.1|3021090_3021618_-|hypothetical-protein
MTKIPQIPAGKGSNIGEFDLADCFFQSGEMLYAAAYDGITKNATRRIGFPTDEYFHGHFIVAFYNFRHAIELKMKQLALLLGITKRYGHKLSDLWDEVLKHAKITANETIVTEALLVLADYDVLQDEELFRYSQRNKSPNQLLQDYPAIQSDSFHLLGKAYCLLSEAILLLTPGK
>CP025491.2|AUH70813.2|3020129_3020897_+|hypothetical-protein
MEHWLYLKTQQKYFQIFLILNIWYIGGWCPVLRNTSKIKHPGTLDVDILFKESYKSGYLQNVIKSFINTGFMPSAKHPFQLLKPKEINGERIIYNVDILHPNMTEYSDQIGMFVDHLELDVPLNNSEKELKKMMSIVLPNSEILFREGLFDEFSRSGEVFKLVSFLGMFITKMDSCQKQKRERDSFDIYLAFLSDGIDVNKIEAIALGDGRIKESLESFKKHLNNDSDTFDKNVQHFCKSIEDSPANFILNKLNA
>CP025491.2|AUH70812.1|3019307_3019883_+|hypothetical-protein
MLQDFLKDKVTLVKNNGTKVRSEIPAQVSSNRIIIFDSSLPIEVGDHILRQLKSGLVEDFIVDDPCFQTGHGSIPDSFQIKVHRSDEPTAKPEVIINQISGNNARINIHSTDNSTNIVGDHNQLFSTMNQLIEDNIDSDDERERLRVLVSELKENVGKPNFKNAYDKFIEGAANHMTIFVPIISALSLLLS
>CP025491.2|AUH70811.1|3019041_3019254_+|hypothetical-protein
MSNKQQISVNTDELKTEIDSYESQMTRLTNNLNQKLKEQFINKPDIYPNFYRYKAAVISFWQNFFKKDFN
>CP025491.2|AUH70820.1|3029753_3029981_+|transcriptional-regulator
MPTHEIANLIHYYRKQSGLSQQELARLAGVGKTVIYDIEKGKESVRLNTLLKVLDVLNIQIKFETPFPQTTDNNT
>CP025491.2|AUH70821.1|3029977_3030286_+|toxin-HipA
MRKAYVSVNGIKAGVLEELEGKKYQFTYLNDYQGAPVSLTMPLTNKIYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKNDYFGQLILVGQDVVGAVTIEELR
>CP025491.2|AUH70822.1|3030282_3031221_+|type-II-toxin-antitoxin-system-HipA-family-toxin
MKRCPITYDVISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGCFEIVDQKGQYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLIYSKDNSFTYFIKRFDRIGHNKKLAVEDFAQLSGEDRHTKYKSSMEKVIAVIAQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKERKISISPAYDLLNSTIAQKNTKEELALPLKGKKNNVTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGSSFLSQSMQEKYLELLEQRCKRLNFFD
>CP025491.2|AUH70823.1|3031916_3033647_+|hypothetical-protein
MNSTKDFFTIVSTPREENGKLYYRSFPSINYNGMCLIADKYNSKYFINESNKRIIVAASKIGFQQQLEPYLKSNKDCMIGFSVPQREGASGHPTPVIFEIHNGKKYLFINDSVGYDTLANSLQLFCEKNNVDLYENPYGRQVDNGSCKSDCLAYLKNSLQMESIAASVTLLNKEETTQYLSQTPSDRPGMPKHKIFLPTGDMLKTIQTSKVLGQNQLDVNQPLVSTKSKNTYMEKMSGYHKGETYYETIDRNTHVKSGDTKVWKERTYLRQKTETHHKQIIDILENKESDYINAAICRAANVFDLNTAIAQKNYPLIDIFREKNTQEPIKEENQELYVEYFKFKLRELLKECITDYKKNVENFNEEKLLPILENPKIQIEEKLNKLLSPEVPISDNFRAHLKFHSIFQENGAPSILLEHAIQVFIEDAKNKENGNKKEHINIIIDKHLHLFTTKAKWMALQGAEYSNASWAMDEIVRTIKRERELFNQAPLSQFDQAQQWLLASCTDIIDRSKDILGKHRGYKELFVQFLSGVTSVSTLGVANYATKKSFYGLFPARTDSAKMLDNFTEEMKGCSH
>CP025491.2|AYK03072.1|3033913_3035284_-|MFS-transporter
MALLNFLKPAPYLDEIQDKTIVKQQYRYWRIRTFYAMYIGYALFYFTRKSFTFAMPALQSALGMTKTELGLIASILSLSYGISKFLSGILGDKSNPRYLMAIGLILTGIVNILFGLSSTWWLFAIFWGLNGWFQGWGWPGCTKLLTHWYSQSERGRWWSIWNTSHNVGGALIPLIVAMCAQYFGWRSAMFVPGIICILGGVFLINRLRDTPQSLGLPAIEQYKEEFSGSSNHHQEKIELSVKEILWNYVLSNQYIWILSISYLFIYIVRTAINDWSMLYLTEVKDYSLITAGSCIIWFEVGGFFGNLVAGWLSDKVFQGKRNPINVLFTAGVFATLILFTVTKEYIPFLDSLFLFFFGFFIFGPQMMIGMACAELTHKKAAATATGFAGFFAYCLGAVLAGAPLGAIIKNYGWDNFFLTLFICCLIPLLMMLPLWHVKVHPKSRKSEFSAKSEFAS
>CP025491.2|AUH73882.1|3035464_3037135_+|hypothetical-protein
MKEIVSLLELEQDQIDFAIHKREVIMVLRRKFRTQKDWIIASFNQYQFTKEESQKVQQAILNGDLRITDLLERPFSHYFWSFFTFKWGEILSGGKRLSKQEVLQVATYSSNGQEFARTPIQNRNRLIKGVPLVIGKVVTSMALCMVFCLGLLSTLGAPFALGLALAIVLSLCNGIVCLLSRGQAMLDSAGFQPKKQKTFKTLEENLKQKTIFDKGQKLFFGIVTLLACISAGISGYAGLVGLLTFLGAGMLASNPLVLIVTIGLSLIAAVSFYSFQAVGIRENYEKFKNLFIEDYKKPYGLLRCILLGVVSTIFLAVYATLTWFTTVSGINKLFNALGSNPDTFLAHVLSMICTSTTMVVNTFSQVYKVFNPKTYVDLKEKFESIHQPPEEYQTKAQKIKYGAINVLKLCALIGDSLAYSVAGGIRSGIHVGETLGEAIGAKLALTITMAILSPVILVFVSIAFTWPTVFQSKKTTQYPSQMEKPLIEKVSQSHNPNALQNNTLLSTSEKFPKTNNSKIRQAGLRFFDASLNEEPIVKPNCSSTLERRTVVTSYSL
>CP025491.2|AUH73883.1|3037198_3038800_+|hypothetical-protein
MFPYLTLAITTSSVWSKNIQSSSSCDPYRNYSCLDSYLGEDFITRFFRYYKLEIGHAAAPSDPHAPTSHRASWPATPESTPPMPFTEWPYGATTSLGVSLPNSVDSPLMVGLANAPVGKWLQKNHIQIYGWVNGGGNLSTNTEKPAGNAPMAYLYTPNTIQLDQAVLYMERVPDTVQTNHVDWGFRLSGIYGENYRYTTAYGIASYQLLNNNSVYGYDFPMVYGELYIPNVAQGLLFRVGRYISIPDIEAQLAPNNYMYSHSMTYTFDNYTNEGIVASLAVAKNVIFQLGLVGGTDTAIWNIGKKVKNPAPNPLYPNPTFLKDPGARISAVACARFTWNDGKDTFYPCMDGINNGVWGYNNLQWYGFTYYHKFNERWHIAYEIYTLHQNNVANINNPIAAALIATGGTPFSPQYIPFNAPNAAQCNSTSALSCTASVLATVAYINYQFSPLDNISFRPEFYDDKQGQRTGVKTRYLNFGLGWQHWLSPQIELRPEIDYDYALDRNAFNGNANAGISPSKRYTVLGAMDIIAHF
>CP025491.2|AUH70824.1|3038871_3040131_-|CPBP-family-intramembrane-metalloprotease
MEEIIDEEIIKILQKNNLFSSLSNKQLNDLMPLIRVIDFDANKLIIYENDNPIDLYIIWKGEVEVLKKAKDGTELRISTLQSGEAIGEMGLIDNSPRSATIRTIVPTKLLVFSIADLKNLTKNTLFYNQLISKLSDVINELQFYINEQPTYLTLISNLAGTLSNRIRQTNQLTVDTLRSDLEHTKARIAMGKFMIDVLLVVVIYMYTFSVLAKLAHSHQSTSIVSIPLIIFFGIIVLFMMKNSSYPLQFYGLTLNNWRRALWEGILLSIPLILLIVLIKWLVINLVPQFSHLTLINAAILTGNDMHPNHNLPSLIALVLAYLVFTPIQELIARGALQSSLQEFLIGPNRIWWAILMSNILFSVTHLHVSISLAIAVLIPGFFWGWLYYRHKTLIGVSISHLIVGGLAFFVFDIRSIFAF
>CP025491.2|AUH70825.1|3040466_3040694_+|hypothetical-protein
MSKYIKSLLLSSSLSFTIFTPGILFADDCDVDCAKGSNQIDCPGKGCGCWCDKDQNAKCKCTQPLDENNTNTKNK
>CP025491.2|AUH70826.1|3040985_3041477_+|Hsp20/alpha-crystallin-family-protein
MSKIAKLKHIHPAEHPSSPFIRLHNEVDRLFGEFSDFFSPTRFRGLEQFEQLNLAPSMDVVEDKDHFSIQLEMPGMDEKDIHLSITDNVLTISGEKSISKKNKHKKYVSREISYGKYERSISLPSSVNVDEVKANFKKGMLWVQLPKKEEATSGSRDIKIEQA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP025491_2	2.2\|3029662\|44\|CP025491\|CRISPRCasFinder	3029662-3029705	44	NZ_LR134418	Legionella adelaidensis strain NCTC12735 genome assembly, plasmid: 9	257659-257702	2	0.955

1. spacer 2.2|3029662|44|CP025491|CRISPRCasFinder matches to NZ_LR134418 (Legionella adelaidensis strain NCTC12735 genome assembly, plasmid: 9) position: , mismatch: 2, identity: 0.955

atggtgaattaatgcaaagaaatacaataataaatttattttta	CRISPR spacer
atggtgaattaatgcaaataaatgcaataataaatttattttta	Protospacer
****************** ****.********************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1041004 : 1119234

Bacillus_phage(28.57%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYK03012.1\|1041004_1042039_-\|transposase	IS481 family transposase	A0A077SLK2	Escherichia_phage	2.4e-156	77.4
AUH72562.1\|1042282_1044037_-	hypothetical protein	NA	NA	NA	NA
AUH72563.2\|1044814_1048873_+	ankyrin repeat domain-containing protein	NA	NA	NA	NA
AUH72564.1\|1049264_1051277_+	diguanylate cyclase	A0A127AWB9	Bacillus_phage	1.3e-12	32.1
AUH72565.1\|1051267_1051633_+	EAL domain-containing protein	NA	NA	NA	NA
AUH72567.2\|1052443_1054414_-	hypothetical protein	NA	NA	NA	NA
AUH72568.1\|1055392_1056991_+	hypothetical protein	NA	NA	NA	NA
AUH72569.1\|1057921_1058425_-	hypothetical protein	NA	NA	NA	NA
AUH72570.1\|1059155_1059734_+	type IV secretion protein IcmC	NA	NA	NA	NA
AUH72571.1\|1059984_1065753_+	serine hydrolase	NA	NA	NA	NA
AUH72572.1\|1066313_1066658_+	hypothetical protein	NA	NA	NA	NA
AUH72573.1\|1067708_1068719_+	esterase family protein	NA	NA	NA	NA
AUH72574.1\|1069500_1070115_-	hypothetical protein	NA	NA	NA	NA
AUH72575.1\|1071278_1073849_-	hypothetical protein	NA	NA	NA	NA
AUH72576.1\|1074172_1074427_-	hypothetical protein	NA	NA	NA	NA
AUH72577.1\|1074641_1075544_+	hypothetical protein	NA	NA	NA	NA
AUH72578.1\|1075522_1076140_+	hypothetical protein	NA	NA	NA	NA
AUH72579.1\|1076146_1078567_+	phosphodiesterase	NA	NA	NA	NA
AUH72580.1\|1080166_1080307_+	DUF3387 domain-containing protein	NA	NA	NA	NA
AUH72581.2\|1081446_1085124_+	hypothetical protein	A0A160ER97	Powai_lake_megavirus	2.8e-05	31.5
AYK03013.1\|1086034_1087210_+\|transposase	ISL3 family transposase	A9YX10	Burkholderia_phage	7.5e-13	20.3
AUH72582.1\|1087774_1089688_+	ankyrin repeat domain-containing protein	NA	NA	NA	NA
AUH72583.1\|1090212_1090419_-	hypothetical protein	NA	NA	NA	NA
AUH72584.1\|1090903_1091815_+	LysR family transcriptional regulator	NA	NA	NA	NA
AUH72585.1\|1092339_1093302_+	LysR family transcriptional regulator	NA	NA	NA	NA
AUH73976.2\|1093710_1093971_+	hypothetical protein	NA	NA	NA	NA
AUH72586.2\|1094051_1094660_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	6.5e-37	42.9
AUH72587.1\|1094662_1094809_+	hypothetical protein	A0A1P8CWQ3	Bacillus_phage	1.2e-05	54.8
AUH72588.1\|1095396_1095936_+	hypothetical protein	NA	NA	NA	NA
AUH72589.1\|1096464_1096668_+	hypothetical protein	NA	NA	NA	NA
AUH72590.1\|1096686_1097406_+	hypothetical protein	NA	NA	NA	NA
AYK03014.1\|1098528_1098666_+	hypothetical protein	NA	NA	NA	NA
AUH72591.1\|1098674_1099262_+	hypothetical protein	NA	NA	NA	NA
AUH72592.1\|1099813_1100026_-	hypothetical protein	NA	NA	NA	NA
AUH72593.1\|1101164_1101449_-\|transposase	transposase	NA	NA	NA	NA
AUH72594.1\|1103377_1104751_-	hypothetical protein	NA	NA	NA	NA
AUH72595.1\|1105147_1105411_+	hypothetical protein	NA	NA	NA	NA
AUH72596.1\|1105688_1105880_+	hypothetical protein	NA	NA	NA	NA
AUH72597.1\|1106103_1106199_+	hypothetical protein	NA	NA	NA	NA
AUH72598.1\|1106668_1107274_+	hypothetical protein	NA	NA	NA	NA
AUH72599.1\|1108006_1110364_-	hypothetical protein	NA	NA	NA	NA
AUH72600.1\|1110389_1110596_-	hypothetical protein	NA	NA	NA	NA
AUH72601.2\|1111334_1111598_+	hypothetical protein	NA	NA	NA	NA
AUH72602.1\|1111875_1112067_+	hypothetical protein	NA	NA	NA	NA
AYK03015.1\|1112290_1112386_+	hypothetical protein	NA	NA	NA	NA
AUH72603.1\|1113510_1115253_+	hypothetical protein	NA	NA	NA	NA
AUH72604.1\|1116092_1117172_-	ankyrin repeat domain-containing protein	NA	NA	NA	NA
AUH72605.1\|1117205_1117433_-	hypothetical protein	NA	NA	NA	NA
AYK03016.1\|1117775_1117943_+	hypothetical protein	NA	NA	NA	NA
AUH72606.1\|1118413_1118797_+\|transposase	transposase	NA	NA	NA	NA
AUH72607.1\|1118757_1119234_+\|transposase	IS3 family transposase	A0A0P0I4A4	Acinetobacter_phage	2.6e-41	56.2

DBSCAN-SWA_2

2003669 : 2010471

Acinetobacter_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AUH73298.1\|2003669_2004467_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.2e-23	33.8
AUH73299.1\|2004599_2005562_+	KpsF/GutQ family sugar-phosphate isomerase	A0A2P0VNK5	Tetraselmis_virus	4.2e-38	32.4
AUH73300.1\|2005561_2006089_+	HAD-IIIA family hydrolase	A0A140XBD6	Dickeya_phage	8.5e-25	43.7
AUH73301.1\|2006085_2006661_+	LPS export ABC transporter periplasmic protein LptC	NA	NA	NA	NA
AUH73302.1\|2006641_2007181_+	lipopolysaccharide transport periplasmic protein LptA	NA	NA	NA	NA
AUH73303.1\|2007177_2007903_+	LPS export ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	3.3e-19	27.0
AUH73304.1\|2008108_2008675_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.5e-56	53.2
AUH73305.1\|2008664_2009699_+	anthranilate phosphoribosyltransferase	A0A0N7IRD9	Acinetobacter_phage	8.4e-77	46.6
AUH73306.1\|2009691_2010471_+	indole-3-glycerol phosphate synthase TrpC	A0A0P0IR83	Acinetobacter_phage	1.1e-55	52.0

DBSCAN-SWA_3

2540858 : 2550329

Bacillus_phage(16.67%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AUH73690.1\|2540858_2542541_-\|protease	serine metalloprotease	A0A1B0T6A2	Bacillus_phage	3.2e-17	28.5
AUH73691.1\|2542955_2544281_-	adenosylhomocysteinase	S4VPF6	Pandoravirus	2.1e-48	31.9
AUH73692.1\|2544291_2545440_-	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	1.7e-126	59.2
AYK03052.1\|2545546_2546659_-	carbamoyl-phosphate synthase small subunit	R4TGJ8	Halovirus	5.5e-50	34.5
AUH73693.1\|2546794_2547940_-	molecular chaperone DnaJ	E3T4P7	Cafeteria_roenbergensis_virus	5.7e-26	37.5
AUH73694.1\|2548385_2550329_-	molecular chaperone DnaK	G8DDB7	Micromonas_pusilla_virus	8.5e-147	49.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. CP025493

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

86044 : 95086

Synechococcus_phage(33.33%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AUH74276.1\|86044_86779_-	hypothetical protein	M1I080	Acanthocystis_turfacea_Chlorella_virus	1.1e-33	38.7
AUH74275.1\|86790_87147_-	capsular biosynthesis protein	M4QRS4	Synechococcus_phage	5.7e-25	42.9
AUH74274.1\|87130_88096_-	hypothetical protein	M4QT73	Synechococcus_phage	1.4e-25	26.7
AYK03143.1\|88705_91963_-\|transposase	Tn3 family transposase	A0A125RQ78	Bacillus_phage	4.3e-228	40.6
AYK03144.1\|92119_92668_+	recombinase family protein	A0A0A7NPV4	Enterobacteria_phage	2.0e-32	46.1
AYK03145.1\|92767_93163_+	DUF302 domain-containing protein	NA	NA	NA	NA
AYK03146.1\|93178_95086_-	cation-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.8e-141	44.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP025491

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. CP025493

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection