CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP023269	Pseudomonas sp. MYb193 chromosome, complete genome	8 crisprs	DEDDh,DinG,RT,csa3,cas3,WYL,PD-DExK	0	0	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP023269_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023269_1

781333-781443

Orphan

Consensus_repeat	Method
TGTAGCTTAGTTGGTTAGAGCGCACCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023269_1

>merge|CP023269|1|781333-781443|CRISPRCasFinder
TGTAGCTTAGTTGGTTAGAGCGCACCCCATGCTTTGTGGTAAAAAGCAGGGTGAGGTCGGCCTTAGCAGCTCGAAATTGGGTCTGTAGCTCAGTTGGTTAGAGCGCACCCC

>CP023269|1|1|781333-781443|CRISPRCasFinder
TGTAGCTTAGTTGGTTAGAGCGCACCCC	ATGCTTTGTGGTAAAAAGCAGGGTGAGGTCGGCCTTAGCAGCTCGAAATTGGGTC
TGTAGCTCAGTTGGTTAGAGCGCACCCC

Protein	Signature genes	Signature genes Name	Protein_function
CP023269.1\|AVJ20830.1\|772983_773643_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|312013
CP023269.1\|AVJ20836.1\|785836_786460_+\|paraquat-inducible-membrane-protein-A	unknown	unknown	gnl\|CDD\|225542
CP023269.1\|AVJ20825.1\|767771_768725_-\|adenosine-deaminase	unknown	unknown	gnl\|CDD\|236480
CP023269.1\|AVJ20837.1\|786452_788756_+\|mammalian-cell-entry-protein	unknown	unknown	gnl\|CDD\|225553
CP023269.1\|AVJ20832.1\|775213_776134_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
CP023269.1\|AVJ20841.1\|793941_794688_+\|energy-transducer-TonB	unknown	unknown	unknown
CP023269.1\|AVJ20843.1\|795252_795657_-\|serine-kinase/phosphatase	unknown	unknown	unknown
CP023269.1\|AVJ20831.1\|773730_775125_-\|xanthine-permease-XanP	unknown	unknown	gnl\|CDD\|274468
CP023269.1\|AVJ20838.1\|788942_791783_-\|chromosome-partitioning-protein-ParA	unknown	unknown	gnl\|CDD\|224117
CP023269.1\|AVJ20834.1\|777649_779143_+\|methylmalonate-semialdehyde-dehydrogenase-(CoA-acylating)	unknown	unknown	gnl\|CDD\|143404
CP023269.1\|AVJ20827.1\|770076_771435_-\|8-oxoguanine-deaminase	unknown	unknown	gnl\|CDD\|236184
CP023269.1\|AVJ20842.1\|794680_795133_+\|ribosomal-protein-alanine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|273701
CP023269.1\|AVJ20840.1\|792476_793754_-\|hypothetical-protein	unknown	unknown	unknown
CP023269.1\|AVJ20829.1\|772389_772971_-\|thymidylate-synthase	unknown	unknown	gnl\|CDD\|224653
CP023269.1\|AVJ20835.1\|785190_785850_+\|paraquat-inducible-protein-A	unknown	unknown	gnl\|CDD\|377345
CP023269.1\|AVJ20839.1\|791779_792487_-\|chromosome-partitioning-protein	unknown	unknown	gnl\|CDD\|319980
CP023269.1\|AVJ20833.1\|776260_777610_+\|aspartate-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|181707
CP023269.1\|AVJ25449.1\|795795_796440_+\|carbonate-dehydratase	unknown	unknown	gnl\|CDD\|238448
CP023269.1\|AVJ20826.1\|768919_770011_+\|calcium:proton-antiporter	unknown	unknown	gnl\|CDD\|223464
CP023269.1\|AVJ20828.1\|771646_772333_-\|short-chain-dehydrogenase	unknown	unknown	gnl\|CDD\|236173

Protein	Function_ID	Function_description	E-value
CP023269.1\|AVJ20830.1\|772983_773643_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|312013	pfam08362, TetR_C_3, YcdC-like protein, C-terminal region. This family comprises proteins that belong to the TetR family of transcriptional regulators. They bear particular similarity to YcdC, a putative HTH-containing protein. This family features the C-terminal region of these sequences, which does not include the helix-turn-helix.	9.67302e-73
CP023269.1\|AVJ20836.1\|785836_786460_+\|paraquat-inducible-membrane-protein-A	gnl\|CDD\|225542	COG2995, PqiA, Uncharacterized paraquat-inducible protein A [Function unknown].	2.75581e-76
CP023269.1\|AVJ20825.1\|767771_768725_-\|adenosine-deaminase	gnl\|CDD\|236480	PRK09358, PRK09358, adenosine deaminase; Provisional.	2.69482e-167
CP023269.1\|AVJ20837.1\|786452_788756_+\|mammalian-cell-entry-protein	gnl\|CDD\|225553	COG3008, PqiB, Paraquat-inducible protein B [General function prediction only].	2.28997e-160
CP023269.1\|AVJ20832.1\|775213_776134_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.21636e-35
CP023269.1\|AVJ20831.1\|773730_775125_-\|xanthine-permease-XanP	gnl\|CDD\|274468	TIGR03173, pbuX, xanthine permease. All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.	3.85453e-136
CP023269.1\|AVJ20838.1\|788942_791783_-\|chromosome-partitioning-protein-ParA	gnl\|CDD\|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	1.72142e-06
CP023269.1\|AVJ20834.1\|777649_779143_+\|methylmalonate-semialdehyde-dehydrogenase-(CoA-acylating)	gnl\|CDD\|143404	cd07085, ALDH_F6_MMSDH, Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2. Methylmalonate semialdehyde dehydrogenase (MMSDH, EC=1.2.1.27) [acylating] from Bacillus subtilis is involved in valine metabolism and catalyses the NAD+- and CoA-dependent oxidation of methylmalonate semialdehyde into propionyl-CoA. Mitochondrial human MMSDH ALDH6A1 and Arabidopsis MMSDH ALDH6B2 are also present in this CD.	0
CP023269.1\|AVJ20827.1\|770076_771435_-\|8-oxoguanine-deaminase	gnl\|CDD\|236184	PRK08203, PRK08203, hydroxydechloroatrazine ethylaminohydrolase; Reviewed.	0
CP023269.1\|AVJ20842.1\|794680_795133_+\|ribosomal-protein-alanine-N-acetyltransferase	gnl\|CDD\|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR\|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	1.50726e-54
CP023269.1\|AVJ20829.1\|772389_772971_-\|thymidylate-synthase	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	1.54596e-64
CP023269.1\|AVJ20835.1\|785190_785850_+\|paraquat-inducible-protein-A	gnl\|CDD\|377345	pfam04403, PqiA, Paraquat-inducible protein A. Paraquat is a superoxide radical-generating agent. The promoter for the pqiA gene is also inducible by other known superoxide generators. This is predicted to be a family of integral membrane proteins, possibly located in the inner membrane. This family is related to NADH dehydrogenase subunit 2 (pfam00361).	3.7542e-54
CP023269.1\|AVJ20839.1\|791779_792487_-\|chromosome-partitioning-protein	gnl\|CDD\|319980	cd16336, MukE, bacterial condensin complex subunit MukE. MukE is part of the MukBEF condensin complex that is mainly found in proteobacteria and is involved in chromosome organization and condensation. The complex is believed to serve as a part of the chromosome scaffold rather than a bulk DNA packing protein. MukE and MukF form a stable complex with each other and dynamically associate with MukB, a member of the SMC protein family. MukEF does not bind DNA on its own but modulates MukB-DNA activity. The stoichiometry of the MukEF complex is MukE4F2.	4.26981e-07
CP023269.1\|AVJ20833.1\|776260_777610_+\|aspartate-aminotransferase-family-protein	gnl\|CDD\|181707	PRK09221, PRK09221, beta alanine--pyruvate transaminase; Provisional.	0
CP023269.1\|AVJ25449.1\|795795_796440_+\|carbonate-dehydratase	gnl\|CDD\|238448	cd00883, beta_CA_cladeA, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	3.09667e-111
CP023269.1\|AVJ20826.1\|768919_770011_+\|calcium:proton-antiporter	gnl\|CDD\|223464	COG0387, ChaA, Ca2+/H+ antiporter [Inorganic ion transport and metabolism].	3.68512e-98
CP023269.1\|AVJ20828.1\|771646_772333_-\|short-chain-dehydrogenase	gnl\|CDD\|236173	PRK08177, PRK08177, SDR family oxidoreductase.	7.81648e-147

>CP023269.1|AVJ20834.1|777649_779143_+|methylmalonate-semialdehyde-dehydrogenase-(CoA-acylating)
MSLIQHLINGELVNDSGRSADVYNPSTGQVIHQVPLASRETIQQAIDSAKAAFPAWRNTPPAKRAQVMFRFKQLLEQNEARISQLISEEHGKTLEDAAGELKRGIENVEYACSAPEILKGEYSRNVGPNIDAWSDFQPLGVVAGITPFNFPAMVPLWMYPLAIVCGNCFILKPSERDPSSTLLIAQLLQEAGLPKGVLSVVHGDKGAVDALIEAPEVKALSFVGSTPIAEYIYSEATKRGKRVQALGGAKNHAVLMPDADLDNAVSALMGAAYGSCGERCMAISVAVCVGDQVADALIAKLVPQVKALKIGAGTSCGLDMGPLVTGQARDKVSGYIEDGVSAGAELVVDGRGLSVAGHEQGFFLGGSLFDRVIPEMRIYKEEIFGPVLCVVRVDSLEAAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEVGMVGVNVPLPVPVAYHSFGGWKRSLFGDLHAYGPDGVRFYTRRKAITQRWPQRASHEASQFAFPSL
>CP023269.1|AVJ20833.1|776260_777610_+|aspartate-aminotransferase-family-protein
MNMPENAPSSLASQLKLDAHWMPYTANRNFQRDPRLIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHTRKEIQEAVAKQLGTLDYSPGFQYGHPLSFQLAEKITDLTPGNLNHVFFTDSGSECADTAVKMVRAYWRLKGQATKTKMIGRARGYHGVNIAGTSLGGVNGNRKLFGQAMMDVDHLPHTLLASNAFSRGMPEQGGIALADELLKLIELHDASNIAAVFVEPMAGSAGVLVPPQGYLKRLREICDQHNILLVFDEVITGFGRTGSMFGADSFGVTPDLMCIAKQVTNGAIPMGAVIASSEIYQTFMNQATPEYAVEFPHGYTYSAHPVACAAGLAALDLLQKENLVQSVAEVAPHFENALHGLKGSKNVIDIRNYGLAGAIQISPRDGDAIVRPFEAGMALWKAGFYVRFGGDTLQFGPTFNSKPQDLDRLFDAVGEVLNKID
>CP023269.1|AVJ20832.1|775213_776134_-|LysR-family-transcriptional-regulator
MSSRRPDPLAQVSDFDIRLLRIFRSVVECGGFSAAETVLGIGRSAISQQMSDLEQRLGLRLCQRGRAGFSLTEEGREVYQSALQLLSALESFRTEVNGLHQHLRGELIIGLTDNLVTLPHMRITHALAQLKERGPDVQIQIRMIAPNEVEQGVLDGRLHVGVVPQASALSGLEYQPLYSERSLLYCAVGHPLFYADNKQLDDERVDSQDAIAPTFRLPAEIQAHYQALNCTASASDREGMAFLILTGRYIGYLPDHYASLWVQQGRLRALKPATRFYDLSLASVTRKGRRPHLVLESFLESLAATR
>CP023269.1|AVJ20831.1|773730_775125_-|xanthine-permease-XanP
MPPESSSPSDLIYGLNDRPKPLPALLAALQHVLAAFVGIITPPLIIGSTLGLTAHLPYLISMALMVSGVGTFIQARRPFGIGAGMICLQGTSFAFLGAVLSAGFLVKQRGGSPEDILAMIFGVCFFGAAVQIVLSRFIGQLRRVITPLVTGIVITLIGISLIKVGITDLGGGFNAPDFGAPANLALGLFVVLTIILLNRSNTPWVRLSAIIIGLALGSLAAWFSGKLIPQALPDLPLVSLPTPFRFGFNFDWSAFLPIALIYLISSIETVGDLTANCMIARQPISGASYISRLKGGVLGDGVSCMIAATFSAFPNTTFAQNNGVIQLTGVASRYVGLYIGVLLFCLGLFPLIGAVLQQIPKPVLGGATLVMFGSVAAAGVRILAQAPLDRRSMLIIATSFGVGLGIAAQPNLLHLMPTLVQNLFDSAITSGGITAILLCLLLPEAKASTTAANHTPERDSLEPL
>CP023269.1|AVJ20830.1|772983_773643_-|TetR-family-transcriptional-regulator
MSLEVPAHSNHGGKPASRIRQKNEQAILQAAEDEFARHGYKGTSMNTIAASAGLPKANLHYYFTNKLGLYIAVLSNILELWDSTFNALTAEDDPAVALARYIRTKMEFSRRQPQASRIFAMEIISGGECLTEYFGQDYRAWFSGRAAVFQAWIDAGKMDPVDPVHLIFLLWGSTQHYADFATQICRVTGRTKLTKQDMEDAGTNLIHIILKGCGIKPAL
>CP023269.1|AVJ20829.1|772389_772971_-|thymidylate-synthase
MSFTLTGFCEFREEIRKSRFITLAAPITSPQDAQAFFERHSDLNATHNCWAWKLGDQYRSSDDGEPGGTAGRPILAAIEAQGFDQVAVLVIRWYGGIQLGTGGLARAYGGGANKCLQNAERIELISRVPLSCACGFSELNLVKLRVAELGGIVVEETFTANGVELQLALGEAHIDTLQTQLADLSRGRILLER
>CP023269.1|AVJ20828.1|771646_772333_-|short-chain-dehydrogenase
MSTPKTALIIGASRGLGLGLVKQLLQDGWDVTATVRDPNKADALKAVGPVQIEKLDMDDQQAVIALAQRLKDRTFDLLFVNAGVKGPANQEPGHATLAEVGQLFFTNAVAPINLAQRFVGQIRKDTGVLAFMSSVLGSVTIPDGSDLALYKASKAALNSMTNSFITQLGEPKPTVLSLHPGWVKTDMGGENAHIDVETSVRGLVDQVNAYTGKGGHHFVDYKGDTITW
>CP023269.1|AVJ20827.1|770076_771435_-|8-oxoguanine-deaminase
MPATRIWLKKPLAIFTANGLDARGGLVLQDGVITEVLAQGQAPAQPCAQVFDAREHVVLPGLINTHHHFYQTLTRAWGPVVNQPLFPWLKTLYPVWARLTPEKLALASKVALAELLLSGCTTAADHHYLFPDGLENAIDVQVGSVRELGMRAMLTRGSMSLGEADGGLPPQQTVQQGQVILEDSQRLIREYHQRGDGAQIQIALAPCSPFSVTPEIMQASAELANQLDVRLHTHLAETLDEEDFCLQRFGLRTVDYLDSVGWLGPRTWLAHGIHFNPDEIERLGAAGTGICHCPSSNMRLASGICPTLDLLAAGAPIGLGVDGSASNDASNMILEARQALYIQRLRYGAEKITPEGVLGWATKGSAQLLGRTDIGELAVGKQADLALFKLDELRFSGSHDPISALLLCGADRADRVMIAGQWRVIDGQVEGLDLKGLIADHSQAARQLIAGI
>CP023269.1|AVJ20826.1|768919_770011_+|calcium:proton-antiporter
MLTSLKQEKFMLLALIAAIAAYPLEHWMLHSGQLVALLAGFALIAFIVMASMRVAHHAEQLAEKVGDPYGTMILTLAAVLVEVVILAIMMSNEPSPTLVRDTIYSAVMLDINGILGLAALMGGIKHGEQSYNDDSARTYSVMILTAMGVSMVVPEFIPEADWKIYSAFTIGAMVVLYTLFLRMQVGPHSYFFSYSYPEKRRKKQPEDEHAPSVSLTFSIATLVFGVIVIGALAEVMSKTLDLGLEGTGAPPVITAIVVAAISAAPEILTALRAALANRMQSVVNIALGASLSTVILTVPVMEAMALYTGQPFQMAMTPVQTVMVFITLIVSAINLNDGETNAIEGMTHFVLFATFIMLSLLGL
>CP023269.1|AVJ20825.1|767771_768725_-|adenosine-deaminase
MYDWLNALPKAELHLHLEGSLEPELLFALAERNKIALPWNDVETLRKAYAFNNLQEFLDLYYKGADVLRTSQDFYDLTWAYLLRCKAQNVIHTEPFFDPQTHTDRGVPFEVVLNGIAAALKDGEQQLGITSGLILSFLRHLSEDEAQKTLDQALPFRDAFVAVGLDSSEMGHPPSKFQRVFDRARHEGFLTVAHAGEEGPPEYIWEAIDLLKIQRIDHGVRAIEDERLMQRIIDEQIPLTVCPLSNTKLCVFDDMAQHNILDMLERGVKVTVNSDDPAYFGGYVTENFHALYTSLGMTQDQAKRLAQNSLDARLVKP
>CP023269.1|AVJ20835.1|785190_785850_+|paraquat-inducible-protein-A
MPDPVDAREVSDLPLDDLVACHECDLLMRKPTLALGEKAQCPRCGYELYAHRHNVVERSLALVLAALLLYVPANFLPIMQLNLLGQSSEDTVWSGVVGLFDTGMQGVAAVVFLCSMGIPLLKLLCQLAVLLSIRWNIGRNYGLLLYRIYHHMKDWGMLEVYLMGVLVAIVKLADMASITIGLGLVCFVSLLMVQVLLEVVMSPHQIWQALSGEDDHAGD
>CP023269.1|AVJ20836.1|785836_786460_+|paraquat-inducible-membrane-protein-A
MRAIDAGILICTECHELNKQEADSEEQLCTRCGALIHARRPNSLTRTWALLITAAILYIPANLLPIMTVNSLGQGDPSTIMSGVIQLVQHGMFPIAAVVFIASILVPTFKLVGIGLLLFSVQRHQPLSAQQRIVMYRFIEFIGRWSMLDIFVIAILVALVNFGRLASIEANLGAAAFASVVILTMFAAVTFDPRLIWDNTESDDDHE
>CP023269.1|AVJ20837.1|786452_788756_+|mammalian-cell-entry-protein
MSDLPKAKTRPASNWSAIWVLPLIALIIGGWLGWRAYSQQGIEIQVRFESGEGIQVNKTEVVYKGMTVGKVKTLALDDEGSNRGVIATIEMNKDVEQYLKTNTRFWLVKPSVSLAGITGLETLVSGNYIAASPGDGEPTRKFKALSEEPPLSDAKPGLHLTLKADRLGSLNRGSPVFYKQIQVGQVKSYLLSEDQSTVEVKVYIEPTYANLVRKHTRFWNASGISIDANLSGLKVRSESLSSIVAGGIAFATPENRKDSPPTDPSLPFRLYEDFDAAAAGIKVKVKLTDFEGLQAGRTPVMYKGIQVGSLKTLKIDPDLSSASAELTLDPLAEDYLVEDTQFWVVKPSISLAGITGLEALVKGNYIAIRPGDKGTPPQREYVARAKAPPLDLRSPGLHMVLLTDSLGSLDVGSPILYKQVKVGSVQSYQFSRKKKQLVIGVHIEKEYESLVNGSTRFWNASGVTLTGGLTGGIQVKSESLASLMAGGIAFETPEPNVPLKHRIPRFRLYADRDAANQHGTLVTIKVDRADGLSAGTPVRFKGLDVGKIESVDLSADMQSVLLKARITQVADRIARTGSQFWVVKPELGLMKTANLETLVTGQYIEVQPAAKNAGPQKSFVALAQPPETVHQEAGLSLTLSAARRGSLKEGVPVTYREVTVGKVTDYELGQTADRVLVHILIEPKYAPLVRSGSRFWNTSGFGLDFGLFKGATVRTESLETLVAGGIAFATPDGERMGNPARPQQTFPLFDKFEDEWLTWAPKIPLGK
>CP023269.1|AVJ20838.1|788942_791783_-|chromosome-partitioning-protein-ParA
MSKERYGIRRFALLNTAGYSLGLFPLEEPLSVYGANNLGKSASINALQFPILARMSDMSFGKYTLEQSRRFYFATDTSYILVEVSLPHGPHVIGVVGRGPGGGFGHQFFAYAGKLDLAHYQKNDTCLRQKELFTNLEREGLKAYELKPDELRRLLVGGHTSVPLDLTLIPLRSTSEQSLKTFRALFINLLHMREITAAKLKQLFLDAFEHSLRSGSVDYIAACEEAFRDVRRMEQDYNSLVAAGPLVEALANGVKQRDALRGKLHRLSPLLDSLLGTWSDYASARKEELTIQAEHYRNEQDALQNDQRGGTQELMRLEREISGIQRWLGELSVLKHRFALVDDVKMLEQQLLAAKDAHDELAGALAQSRQFSAEDLEERLRDLEKRLKSVKQQLDHADNNSYAKLREEFSQQDVERLMRLFNSSLFSLPLGEHGITLDEDGQWVKSLEQILDGFKGERFEVPGLSIDISHIEPPALQALADRAALRDQKERLEKELKQLKTQQAVASDRAASKTQTEALYQQVLDAQKALEDFRRTQTLSAEEGEKLENLAQMEAAQDELKRSSDAFTERVQQLSAKLQLVGRQIGDMEAKQRTLDDALRRRQLLPADLPFGTPFMDPVDDSMDNLLPLLNDYQDSWQGLLRADGQIEALYAQVRLKGVAKFDSEDDVERRLQLLINAYAHRTDEALTLGKARRAAVTDIARTLRNIRSDYDSLEHQLALFNREINKRQVSNLQSFRIVLAPNKEALKHIDQIIHSAGQYEEGETLSVFDLSQSAEQDNKNEEAKEYLARLVAANHNQLGLKDLFELAFEITKVNGQPVIHTDIDGAASNGTTMTIKALTNMYLLLHLMDRDQAGRVRLPYYLDEAADIDEKNQAALLETSLQLGFVPILASVKPQVSAQVAIDLEGGSGPNGIYIDEADWKYIRRHDVVKATMNVQADEPELDEV
>CP023269.1|AVJ20839.1|791779_792487_-|chromosome-partitioning-protein
MHLDLSELSQLAPIFRELFKGYHVSRRDPELYAQLSNFQDQYRTLFKALGFELVCDTRGFYYFVPDTAVAAAQVNKTAQRLALFTFIIVEHLADQGRDPIAVLDGGSLGRDELPSLLEKYRDLFIQAEVQTQEELEEKIMRRMTQLGFASEDNGIYRFLPPMHRFLDVCLSVQQDRDLAASVHSVLPLPAPVIIDEDSDEKLLKTDDPLDLSAFTEESEEDALARAIAEEQETDA
>CP023269.1|AVJ20840.1|792476_793754_-|hypothetical-protein
MIEPKRVLRALAEHWALLEPLCEHFDQGTLSLAELRAQLAAQQLDSTPQDITSLLDVWIRLDILVPVAKSPNRFELNAQIHDFLAYLRKEHRLGLCLEIEAYLRHLERLAGYIQDAFDIRDGHDLARQLRLLDMRVRDVLKKLANDEQALAAVADRAKTSDRQIPLRQRYAEVLATWDEYVEPMIQLVNADGAFEQGVRKVENVLLRMLTEQQRLGHLVDDDMLLRTHARILEMQTSAQLTLRHARELLLPLREEARRHNAVTRGAALALSAIRRKGLDAVPQAAMPMFTRPQSTFLGSASQVEAYVYALANFEPKPARFPKAHKSHKGEAPRAPRTVKEMLERCEDALPMPDLMTWLLEQEPDGATDELLYWFSRLSREKRFKRERLERRDYHTHEHQVSLRSFALLPAGVDATENSASTPYAS
>CP023269.1|AVJ20841.1|793941_794688_+|energy-transducer-TonB
MQVVNWLPRTELPFAAPSRPELLQALEPYEAFESSGEEAAAPVAVVKPTPETRPVVERAKIEVPRPVPVTKAAKVVEEAAPVAKAPVVPPPRFALQLLRAGRCLLLVELPTGERFQSRDPAYLLLKDMLRAAGLPDSPQIVGEPVRWPLLVRGTMDQGPEAARDFVQGFVSARLEDEPCVCLWLIGLPAVRFAGEANAEAWYRELQVEGLGSVWALPGLELLMEEPQRKADVWQAMRRLMARWKTTDE
>CP023269.1|AVJ20842.1|794680_795133_+|ribosomal-protein-alanine-N-acetyltransferase
MSEALSFRPMTEADLDAVLKIEYAAFSHPWTRGIFLDGLGKYQIWLMFEGEQQVGHGVVQIILDEAHLLNITVKPENQGRGLGLALLEHLMSRAYAANARECFLEVRDSNTGAFRLYERYGFNEIGRRRDYYPAVGGREDAVVMACTLVD
>CP023269.1|AVJ20843.1|795252_795657_-|serine-kinase/phosphatase
MTESRRPYGATQPEPIDDNEDRMGEMRELDFDEQDQTAEIGDELPRRERDHLMPDERVREAGLTGASTDDHESTDDDMSPETLIREDGARDAQEEGEDSAADYDLSVVGENDIGGGNGLDEAELADLDPLNGKR
>CP023269.1|AVJ25449.1|795795_796440_+|carbonate-dehydratase
MNELQDLLDNNERWADAIKQEDPEFFAKLARQQTPEYLWIGCSDARVPANEIVGMLPGDLFVHRNVANVVLHTDLNCLSVIQYAVDVLKVKHILVTGHYGCGGVRASMQDRQFGLIDGWLRTIRDLYYENRDVLAQLPTEEERVDRMCELNVIQQVANVGHTSIVQNAWHRGQSLSIHGCIYGIKDGRWKSLNTTISGFEQLPPQYRLRPLGEA

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Crispr_ID: CP023269_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023269_2

1765893-1765989

Orphan

Consensus_repeat	Method
AATGTGGGAGCTGGCTTGCCCGCGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023269_2

>merge|CP023269|2|1765893-1765989|CRISPRCasFinder
AATGTGGGAGCTGGCTTGCCCGCGATGACGGCCCGCCAGCCGACGCCTTTCTACCTGATGCCCCGCGATTCAAATGTGGGAGCTGGCTTGCCTGCGA

>CP023269|2|2|1765893-1765989|CRISPRCasFinder
AATGTGGGAGCTGGCTTGCCCGCGA	TGACGGCCCGCCAGCCGACGCCTTTCTACCTGATGCCCCGCGATTCA
AATGTGGGAGCTGGCTTGCCTGCGA

Protein	Signature genes	Signature genes Name	Protein_function
CP023269.1\|AVJ21729.1\|1766272_1767046_-\|ArtI-protein	unknown	unknown	gnl\|CDD\|270231
CP023269.1\|AVJ21728.1\|1765016_1765868_+\|transcriptional-regulator-CynR	unknown	unknown	gnl\|CDD\|183051
CP023269.1\|AVJ21731.1\|1768882_1769482_+\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
CP023269.1\|AVJ21735.1\|1772190_1772784_-\|nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|380315
CP023269.1\|AVJ21721.1\|1758805_1758985_+\|hypothetical-protein	unknown	unknown	unknown
CP023269.1\|AVJ21720.1\|1757808_1758714_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
CP023269.1\|AVJ21734.1\|1771135_1772068_+\|hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240625
CP023269.1\|AVJ21725.1\|1762867_1763707_-\|calcium-channel-protein	unknown	unknown	gnl\|CDD\|377967
CP023269.1\|AVJ21726.1\|1763763_1764234_-\|cyanase	unknown	unknown	gnl\|CDD\|235079
CP023269.1\|AVJ21723.1\|1760033_1761227_+\|4-hydroxybenzoate-3-monooxygenase	unknown	unknown	gnl\|CDD\|236198
CP023269.1\|AVJ21727.1\|1764262_1764904_-\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|238449
CP023269.1\|AVJ21724.1\|1761293_1762811_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
CP023269.1\|AVJ21730.1\|1767411_1768782_+\|glutamine-synthetase	unknown	unknown	gnl\|CDD\|223252
CP023269.1\|AVJ21722.1\|1758977_1759853_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380403
CP023269.1\|AVJ21737.1\|1773400_1774621_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226483
CP023269.1\|AVJ21733.1\|1770734_1771028_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225642
CP023269.1\|AVJ21736.1\|1772937_1773387_+\|YcgN-family-cysteine-cluster-protein	unknown	unknown	gnl\|CDD\|235356
CP023269.1\|AVJ21732.1\|1769604_1770738_+\|ribonuclease-D	unknown	unknown	gnl\|CDD\|130455
CP023269.1\|AVJ21719.1\|1756836_1757703_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293825
CP023269.1\|AVJ21738.1\|1774686_1775037_-\|DUF2892-domain-containing-protein	unknown	unknown	gnl\|CDD\|378561

Protein	Function_ID	Function_description	E-value
CP023269.1\|AVJ21729.1\|1766272_1767046_-\|ArtI-protein	gnl\|CDD\|270231	cd01069, PBP2_PheC, Cyclohexadienyl dehydratase, a member of the type 2 periplasmic binding fold protein superfamily. This subfamily includes cyclohexadienyl dehydratase PheC. These proteins catalyze the decarboxylation of prephenate to phenylpyruvate in the alternative phenylalanine biosynthesis pathway in some proteobacteria and archaea. The PheC proteins belong to the PBPII superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. Since they the PheC proteins are so similar to periplasmic binding proteins, (PBP), it is evolutionarily plausible that several pre-existing PBP proteins might have been recruited to perform the enzymatic function.	3.50609e-113
CP023269.1\|AVJ21728.1\|1765016_1765868_+\|transcriptional-regulator-CynR	gnl\|CDD\|183051	PRK11242, PRK11242, DNA-binding transcriptional regulator CynR; Provisional.	2.88751e-163
CP023269.1\|AVJ21731.1\|1768882_1769482_+\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	9.39339e-18
CP023269.1\|AVJ21733.1\|1770734_1771028_+\|hypothetical-protein	gnl\|CDD\|225642	COG3100, COG3100, Uncharacterized protein conserved in bacteria [Function unknown].	2.3661e-37
CP023269.1\|AVJ21732.1\|1769604_1770738_+\|ribonuclease-D	gnl\|CDD\|130455	TIGR01388, Ribonuclease_D, ribonuclease D. This model describes ribonuclease D, a 3'-exonuclease shown to act on tRNA both in vitro and when overexpressed in vivo. Trusted members of this family are restricted to the Proteobacteria; Aquifex, Mycobacterial, and eukaryotic homologs are not full-length homologs. Ribonuclease D is not essential in E. coli and is deleterious when overexpressed. Its precise biological role is still unknown. [Transcription, RNA processing].	5.60111e-139
CP023269.1\|AVJ21720.1\|1757808_1758714_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.80658e-79
CP023269.1\|AVJ21734.1\|1771135_1772068_+\|hydroxyacid-dehydrogenase	gnl\|CDD\|240625	cd05300, 2-Hacid_dh_1, Putative D-isomer specific 2-hydroxyacid dehydrogenase. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomains but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric. Formate dehydrogenase (FDH) catalyzes the NAD+-dependent oxidation of formate ion to carbon dioxide with the concomitant reduction of NAD+ to NADH. FDHs of this family contain no metal ions or prosthetic groups. Catalysis occurs though direct transfer of the hydride ion to NAD+ without the stages of acid-base catalysis typically found in related dehydrogenases. FDHs are found in all methylotrophic microorganisms in energy production and in the stress responses of plants.	2.39576e-110
CP023269.1\|AVJ21719.1\|1756836_1757703_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293825	cd07739, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	7.31357e-99
CP023269.1\|AVJ21726.1\|1763763_1764234_-\|cyanase	gnl\|CDD\|235079	PRK02866, PRK02866, cyanate hydratase; Validated.	2.43188e-89
CP023269.1\|AVJ21723.1\|1760033_1761227_+\|4-hydroxybenzoate-3-monooxygenase	gnl\|CDD\|236198	PRK08243, PRK08243, 4-hydroxybenzoate 3-monooxygenase; Validated.	0
CP023269.1\|AVJ21727.1\|1764262_1764904_-\|carbonic-anhydrase	gnl\|CDD\|238449	cd00884, beta_CA_cladeB, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	3.52702e-93
CP023269.1\|AVJ21724.1\|1761293_1762811_+\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.27857e-70
CP023269.1\|AVJ21722.1\|1758977_1759853_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|380403	cd06999, cupin_HpaA-like_N, AraC/XylS family transcriptional regulators similar to HpaA, N-terminal cupin domain. Members of this family contain an N-terminal cupin domain and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain, similar to Escherichia coli 4-hydroxyphenylacetate catabolism regulatory protein HpaA (also known as 4HPA). HpaA is encoded by the hpaA gene which is located upstream of hpaBC. It is activated by 4-HPA, 3-HPA and phenylacetate, and represents a member of the AraC/XylS family of regulators that recognizes aromatic effectors. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	4.51912e-51
CP023269.1\|AVJ21737.1\|1773400_1774621_+\|hypothetical-protein	gnl\|CDD\|226483	COG3975, COG3975, Predicted protease with the C-terminal PDZ domain [General function prediction only].	0.00027442
CP023269.1\|AVJ21725.1\|1762867_1763707_-\|calcium-channel-protein	gnl\|CDD\|377967	pfam08269, dCache_2, Cache domain. Double Cache domain 2 (dCache_2) may be a result of single Cache domain 2 (sCache_2) duplication.	1.3217e-08
CP023269.1\|AVJ21736.1\|1772937_1773387_+\|YcgN-family-cysteine-cluster-protein	gnl\|CDD\|235356	PRK05170, PRK05170, YcgN family cysteine cluster protein.	2.48929e-81
CP023269.1\|AVJ21735.1\|1772190_1772784_-\|nitroreductase-family-protein	gnl\|CDD\|380315	cd02138, TdsD-like, nitroreductase similar to Burkholderia pseudomallei TdsD. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.	1.62782e-87
CP023269.1\|AVJ21730.1\|1767411_1768782_+\|glutamine-synthetase	gnl\|CDD\|223252	COG0174, GlnA, Glutamine synthetase [Amino acid transport and metabolism].	5.57672e-145
CP023269.1\|AVJ21738.1\|1774686_1775037_-\|DUF2892-domain-containing-protein	gnl\|CDD\|378561	pfam11127, DUF2892, Protein of unknown function (DUF2892). This family is conserved in bacteria. The function is not known.	6.73803e-05

>CP023269.1|AVJ21728.1|1765016_1765868_+|transcriptional-regulator-CynR
MLLRHIRYLLAVAEHRNFTRAAEALHVSQPTLSQQIKQLEESLGAPLLDRSGRSVSLTDAGQAYVRYARLALQDLQAGTRAIHDVQDLRRGHLRLAMTPTFTAYLIGPLLARFNALYPGITLSIEELTQDRIEAALGEDLLDIGIGFTGEHGLEIDCEALFVEELSLVVSASHPERTQPAWLEHPLVLLNTGFATRRYIDDYCHQQGVKPQIAMEANSISAIIEIVRSTPLATILPRALAESQAGLHAVAIDPPLPQRTAALLSRKGAYRSAACAAFVALIKA
>CP023269.1|AVJ21727.1|1764262_1764904_-|carbonic-anhydrase
MQHLIDGFRKFQREAFTPRSDLFKHLATTQNPGTLFVSCSDSRVVPELLTQQEPGDLFVIRNAGNIVPSYGPEPGGVSATVEYAVAVLGVSDIVICGHSDCGAMTAISTCKCLDHLPAVANWLRHAESAKVINAARTHVSDAARLDSLVRENVVAQLANLKTHPSVALALEQGRMNLHGWVYDIETGGIDALDGHTGRFVSLLDHPSTRAHAA
>CP023269.1|AVJ21726.1|1763763_1764234_-|cyanase
MLQSQFAQTPRLALADTVIDLKARKNLSWQDLTDGTGLSLAFVTAALLGQHPLPKEAADIVCGKLGLDEDASRLLQSVPLRGSFPSGVPTDPTMYRFYEMLQVYGSTLKALVHEQFGDGIISAINFKLDIKKVEDPDGGSRAVITLDGKYLPTKPF
>CP023269.1|AVJ21725.1|1762867_1763707_-|calcium-channel-protein
MKRLLRFTWLLLLCCSQVHAATAQEADAQAAKALLEKALAYYHKQGDKAFAAFSRQGEFIDQDRYVFVVDTKGVLLASGGPSSALIGRDVSEVLGPDLQASFKQALSVPEDQGIQQADYRWQNWNDGKVEHKHVFYQRVGERILAVGYYLPRATPEQARALRNKAVEALVKDETGTLKAINSLQSGFLQDDLYVFVVDLNTRRYVAHGTNLRLLNTDFAKIKDPDGKPVGVPILQMMAEQDQGEYKYRWKNPVTGKVENKHAYVRKSGHFMVAVGYYSP
>CP023269.1|AVJ21724.1|1761293_1762811_+|MFS-transporter
MTHLNQPAPTVPAVRSILVALMMAIFLGALDQTIVAVSMPAISAQFHDVNLLAWVISGYMVAMTVAVPIYGKLGDLYGRRPMMLIGMGVFTLASLFCGLAQSMEQLVLARVLQGIGAGGMVSVSQAIIGDIIPPRERGRYQGYFSSMYAVASVAGPVLGGYMTEYLSWRWVFLINLPLGVGAWYVAHRTLVGLPVPQRKPIIDYLGTVLMIVGLTALLLGITEIGQGHSWRDDQVLGLLACALMALSVFVWHERRAREPLLPMHLFANRSAVLCWCTIFVTSFQAISLTVLMPLRYQTVTGAGADSAALHLLPLAMGLPMGAYFAGRMTSVTGRYKPMILSGALLSPLAILGMAYSAPQAVAFTSVFMLLCGIAAGMQFPTSLVGTQNSVEQRDIGVATSTTNLFRSLGGAVGVACMSALLLALLHDSSFAHLTSGALVAEGSSGNVLLDGLNAAPGPAQDALRGELAVTFRHLLMVSAAVSLLGLAAAIAMPNRVLRGREDNVR
>CP023269.1|AVJ21723.1|1760033_1761227_+|4-hydroxybenzoate-3-monooxygenase
MKTLKTQVAIIGAGPSGLLLGQLLHNAGIQTLVLERQSADYVQGRIRAGVLEQGMVDLLREAGVSQRMDAEGLVHDGFDIALNGQLTSIDLKALTGGQSVMIYGQTEVTRDLMAARAAAGAITLYEVSNVQPHDLKSEQPWLTFEHEGQACRLECDYIAGCDGFHGVARQSIPAQALKVFERVYPFGWLGVLADTPPVHAELVYAKHARGFALCSMRSPTRSRYYLQVPVEEKLEDWADERFWDELKNRLPGSLAERLVTGPSIEKSIAPLRSFVVEPMQYGRLFLLGDAAHIVPPTGAKGLNLAASDVSTLFRILLKVYREGRLDLLEKYSAICLRRVWKAERFSWWMTSMLHQFPQADDFSQRIAESELDYFIRSEAGRKTIAENYVGLPYEPIE
>CP023269.1|AVJ21722.1|1758977_1759853_-|AraC-family-transcriptional-regulator
MTKTAIPVFKLYGESQQWPTPDLLHCETISRRSREYQWEIQPHRHADLCQLLYVHKGQAQLEIEGQRTTLNESSLQVLPPLCVHGFRFSEDVEGFVVTLSAPLVSHLQAQLGSTVDGLHTLGSYPAGKDSDYLNSLFVRLQDEYADDQPARDMMLHALVSVLLVWVSRQAIQRRHPRAPRGREYFRRFTQLVEQHYREHPKIEDLAHKLGISVSHLNGTCRELGGQPALQIMHDRQLLEAKRLLTYTSMTINEMSEVLGFSDPTNFSRLFRRRVGFSPKAFREQLKAEQPT
>CP023269.1|AVJ21721.1|1758805_1758985_+|hypothetical-protein
MSIKTRKYLTIFTLCALATALYGTAAYRVEQTRMQPAAFAISCHQDQCVPRTGSFSALR
>CP023269.1|AVJ21720.1|1757808_1758714_+|LysR-family-transcriptional-regulator
MDRLQAMRVFVTVVDLGSQSAAADHLDLSRPVVSRYLAELEDWVGARLLHRTTRKLSLTAAGGETLPRCRQLLDLCGDMQAAVSEPDDAPRGLLRLSVSTSFGQAQLGAAIAEYVKLYPLVTVDLQMLDRTVNLVDERIDLAIRTSNDLDPNLIARRLTVCRSVVCATPAYLREHPAPQKVEDLARHNCLTHSYFGKSLWHFEENGEHVSVPVHGNITANEASTLMRVTLAGAGVAMLPSYQAGELIRSGELVRLLPHAEPRQMNIYAVYASRKHMPSALRSLLDFLVLRFPEEPVWDVGL
>CP023269.1|AVJ21719.1|1756836_1757703_-|MBL-fold-metallo-hydrolase
MFSTFKRLTLATTALAFAAHAAAADLKLDVYNPGEAAIFPVSSVLVSGEKDAILVDAQFGKGQAEQLVQKIRASGKHLTTIYISHGDPDYYFGLDTLTAAFPDAKVLAPQPVVDHINATVADKLAFWGPKMGADKPAKTLVPQVLKGHSLTLEGQQLEVVGIDGPQPDRSFVWIPSIKAVVGGVVIAENIHVWMADTQSAQSHKDWLATLKRIEDLKPNTVVPGHYLGTPSLASVNFTADYIKAFDLETAKAKDSAALIAAMKKRYPTLADESSLELSAKVAKGEMKW
>CP023269.1|AVJ21729.1|1766272_1767046_-|ArtI-protein
MKAPLALCVLASLATVAQADTAASRLDDVIARGTLTVCTTGDYKPYTSLRSDGGYEGIDIAMAESLAKSLNAKINWVPTTWKTLMPDFLAQRCDIAVGGISVSLERQKKAFFSQSLGVDGKIPLVRCADVQRYQTVEQINQPQVRVIEPAGGTNEVFARAHLGQTQIRLHDNVTIFDELLAGKADVMITDASEARYQQKLKPGLCAVNPEQPMQYSEKAFLLPRDDVAWKSYVDQWLHLSVATGAYAGIVGQWLAAP
>CP023269.1|AVJ21730.1|1767411_1768782_+|glutamine-synthetase
MSVFASLHEAQTFLEQNSDIEMFELFILDNNGVPRGKLLHRDELLAVYESGRPLPSTILGLTINGDDVENSGLVWEVGDIDCRAYPISGSLQRMPWRLIPTAAVQVSMHPTEGLPATVADPRHLLANVIEALKADGYYPVMAAELEFYLLDQKPDSNGRPQPARDVDGNRPRSTQVYGLRELEQIEPFLADLYSACKLQGIPARTAISEYAPGQVEITLEHRTDALQAMDEAVRYKRLVKGVAHKHGMTACFMAKPFDDLAGTGMHMHVSLADAQGNNLFASEATDGTLLLRQALGGMLSTLLDSLLMFCPNANSYRRFQTNSYAPLAATWGVDNRTVSLRVPGGPAQSRHIEHRICGADANPYLAAAAILAGIHRGIREQLDPGAPVQGNGYAQAKELLPTDWLTTLRALETSRWAPDAFGREFLGVYLAVKRAEYRQFMGEVGEQDWRWYLHQA
>CP023269.1|AVJ21731.1|1768882_1769482_+|class-I-SAM-dependent-methyltransferase
MSPQPPSSIETEFTERYDREHARGCGDPRPPRLLQRLSAWRDARLVRQALKVAGEPGLILDLACGSGRFWPVLAEHVNRVILASDNSQAMLDHARTHHPGGLLKRVKTFQGSAFSIGLSANAVDCIFCLDLFRHVPDSDARLMLLHEFHRVSRDTVIVAVNVGTPVESEFRQAGFKILNYQEFLPGSRRWCVYVLRKRG
>CP023269.1|AVJ21732.1|1769604_1770738_+|ribonuclease-D
MAIDIHWICDNDSLGQHCAEWQQLPFVALDTEFMRVDTFYPIAGLIQIGDGVRAYLIDPLTIDNWQPLAALLENPAVIKVVHACSEDLEVLSRLTGSLPVPLFDTQLAAAYLNLGFSMGYSRLVQAVLDIELPKGETRSDWLQRPLSETQISYAAEDAVHLAEVYTRLRPQLSDDKYAWVLEDGAELVANLRREIDPYEVYRDAKLAWKLSRAQLAVLRELCAWREQQARARDLPRNRIIREHSLWPLAKSQPDNLAALGKIEDMHPRTVRQDGQFLLDLIKRTGSVPMDQWPPAVAEPLPVDAAALIKQLRALGQTFAERLDMAPELMLRKKTLEALVKSGYPDGPYQLPDSLRGWRRELMGQALLDSLANAGEQP
>CP023269.1|AVJ21733.1|1770734_1771028_+|hypothetical-protein
MKRICSIYRSKKKDGMYLYVLKSDALERVPEPLMEAFGKAHHAFDMVLTPERKLSREDIAVVLENLDKQGYHLQMPPAEDEYIEHLPEELLRRNDPM
>CP023269.1|AVJ21734.1|1771135_1772068_+|hydroxyacid-dehydrogenase
MRVLIAEQDHPLYAQLLRDAAPDLEVLTSGDSAELSRLAADCPVWLGQPDLLATLLRQGHHPQWLQSTWAGITPLLADGLPRDYRLTRAVGIYGQVMAEFVLTYMLGHEREVLARLVSQVERKWDNRMGQSLAGRKALIVGTGDIGQRVAEFLLPFGVQLYGIASQGREQAPFIEVAGLDQLGRLVGEVDYVINLLPNTPDTHDLYDAALFKQFKPTGLFINVGRGVAVVDADLVEALKEGHLAGAVIDVCRQEPLPQRHPFWTAWGLLLTGHSSAPTSPPMMVELFVQNLRAYQAKQALRGEVDFERGY
>CP023269.1|AVJ21735.1|1772190_1772784_-|nitroreductase-family-protein
MSNNPRVADYPIHTQFTERWSPRAFTGESIPQETLLSFFEAARWAPSAYNSQPWRFLYARRDTPDWERFLGLLNEFNRNWAQHASALVIIASKTDFIAPGATEETPALWHTFDTGSAWGHLALQASLSGWHTHGMAGFDQELTRKELKIPQGYALHAAVAVGKLGDKSSLPEYLQGREMPSPRKPLSELVSEGDFSL
>CP023269.1|AVJ21736.1|1772937_1773387_+|YcgN-family-cysteine-cluster-protein
MAAKVEPFWIRKTLEHLDQEEWESLCDGCGLCCLQKLEDEDDNSVYYTRIACKLLDLKTCQCTDYPNRRASVPDCIQLTPGQADQFKWLPPTCGYRLVSERKDLPLWHHLVCGDRDAVHHERISQSGRMLSEGSVPEDDWEDYLIFRAG
>CP023269.1|AVJ21737.1|1773400_1774621_+|hypothetical-protein
MKVAAKWAAGLVVLALSGPGWCAKKVDLDYHIKLLPQSQQAEVRVSLSQGAAVRSLNFDLGRDGDYSDFKADGQWQVTGNRGLWQPSPDKASLTYRVRLAHVRKPGVYDTRITPGWALLRGEDLVPAARLDQQDGIELVSRLMFELPTGWKSVETAWPRIGQNKFRIDNVSRLFDRPTGWMLAGNLGSRRLRLGETDVTVASPKGQGMRRMDVLTLLTFVWPQVEAAFPRHPGKLLIVGANDPMRRGAYSLRDSIYLNSRTPLVGENGSSPLLREVVQAIGRFNDHDSSDWISEGLGEYYAIELMRRAGGITDERYAAIQARLTKEGKDVTTLKGEHVNGATLARSVVVLQELDREIRVKTHNKRSLDDLAQAVMRVNSVNTKEFVQLAESVIGESSVVLDSKLLR
>CP023269.1|AVJ21738.1|1774686_1775037_-|DUF2892-domain-containing-protein
MSDSKTLRPIIEATPLKPQPTQNVHGWERIGSVAGGVMMVGKGLRRGGIFGLIQVAIGGVALARGFTGHSSLKDKLEQGRQEMNSVRTKIERAGEELKNLKTKAEVAAEKAVKPKA

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Crispr_ID: CP023269_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023269_3

2201741-2201836

Orphan

Consensus_repeat	Method
TCTACCTGACACCCCACAATCCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023269_3

>merge|CP023269|3|2201741-2201836|CRISPRCasFinder
TCTACCTGACACCCCACAATCCAAATGTGGGAGCTGGCTTGCCTGCGATGATGGCCTGACAGCCGACGCCTCTCTACCTGACACCCCACGATCCAA

>CP023269|3|3|2201741-2201836|CRISPRCasFinder
TCTACCTGACACCCCACAATCCAA	ATGTGGGAGCTGGCTTGCCTGCGATGATGGCCTGACAGCCGACGCCTC
TCTACCTGACACCCCACGATCCAA

Protein	Signature genes	Signature genes Name	Protein_function
CP023269.1\|AVJ22098.1\|2191780_2192578_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224512
CP023269.1\|AVJ22108.1\|2203962_2204874_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
CP023269.1\|AVJ25499.1\|2207627_2208029_+\|cytochrome-C	unknown	unknown	gnl\|CDD\|365823
CP023269.1\|AVJ22111.1\|2208107_2208608_+\|RNA-polymerase-subunit-sigma-24	unknown	unknown	gnl\|CDD\|171560
CP023269.1\|AVJ22106.1\|2202238_2202919_-\|dimethylglycine-dehydrogenase	unknown	unknown	gnl\|CDD\|153233
CP023269.1\|AVJ22102.1\|2196822_2199309_-\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|227114
CP023269.1\|AVJ22110.1\|2206680_2207481_-\|sugar-dehydrogenase	unknown	unknown	gnl\|CDD\|187616
CP023269.1\|AVJ22114.1\|2212355_2212613_-\|hypothetical-protein	unknown	unknown	unknown
CP023269.1\|AVJ22105.1\|2201034_2201664_+\|lysine-transporter-LysE	unknown	unknown	gnl\|CDD\|224199
CP023269.1\|AVJ22107.1\|2203008_2203977_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|227311
CP023269.1\|AVJ22099.1\|2192584_2193496_-\|glycosyl-transferase	unknown	unknown	gnl\|CDD\|366154
CP023269.1\|AVJ22113.1\|2209682_2212076_+\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|227113
CP023269.1\|AVJ22112.1\|2208634_2209585_+\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|226235
CP023269.1\|AVJ22109.1\|2204861_2206688_-\|glucoamylase	unknown	unknown	gnl\|CDD\|225922
CP023269.1\|AVJ22104.1\|2200350_2200866_-\|RNA-polymerase-subunit-sigma	unknown	unknown	gnl\|CDD\|171561
CP023269.1\|AVJ22097.1\|2189724_2191704_-\|lipopolysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|225747
CP023269.1\|AVJ22096.1\|2188543_2189725_-\|glycosyl-transferase-family-1	unknown	unknown	gnl\|CDD\|340849
CP023269.1\|AVJ22103.1\|2199413_2200364_-\|siderophore-interacting-protein	unknown	unknown	gnl\|CDD\|236622
CP023269.1\|AVJ22100.1\|2193495_2194956_-\|mannose-1-phosphate-guanylyltransferase/mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|273648
CP023269.1\|AVJ22101.1\|2194955_2196395_-\|undecaprenyl-phosphate-glucose-phosphotransferase	unknown	unknown	gnl\|CDD\|274396

Protein	Function_ID	Function_description	E-value
CP023269.1\|AVJ22098.1\|2191780_2192578_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224512	COG1596, Wza, Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis].	9.99381e-28
CP023269.1\|AVJ22108.1\|2203962_2204874_-\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	4.50111e-29
CP023269.1\|AVJ25499.1\|2207627_2208029_+\|cytochrome-C	gnl\|CDD\|365823	pfam00034, Cytochrom_C, Cytochrome c. The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.	3.30641e-05
CP023269.1\|AVJ22111.1\|2208107_2208608_+\|RNA-polymerase-subunit-sigma-24	gnl\|CDD\|171560	PRK12527, PRK12527, RNA polymerase sigma factor; Reviewed.	3.21505e-37
CP023269.1\|AVJ22106.1\|2202238_2202919_-\|dimethylglycine-dehydrogenase	gnl\|CDD\|153233	cd03139, GATase1_PfpI_2, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	2.02736e-87
CP023269.1\|AVJ22102.1\|2196822_2199309_-\|TonB-dependent-siderophore-receptor	gnl\|CDD\|227114	COG4773, FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism].	0
CP023269.1\|AVJ22110.1\|2206680_2207481_-\|sugar-dehydrogenase	gnl\|CDD\|187616	cd05358, GlcDH_SDR_c, glucose 1 dehydrogenase (GlcDH), classical (c) SDRs. GlcDH, is a tetrameric member of the SDR family, it catalyzes the NAD(P)-dependent oxidation of beta-D-glucose to D-glucono-delta-lactone. GlcDH has a typical NAD-binding site glycine-rich pattern as well as the canonical active site tetrad (YXXXK motif plus upstream Ser and Asn). SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	2.70611e-132
CP023269.1\|AVJ22105.1\|2201034_2201664_+\|lysine-transporter-LysE	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	4.77569e-32
CP023269.1\|AVJ22107.1\|2203008_2203977_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	3.38775e-83
CP023269.1\|AVJ22099.1\|2192584_2193496_-\|glycosyl-transferase	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	8.91194e-17
CP023269.1\|AVJ22113.1\|2209682_2212076_+\|TonB-dependent-siderophore-receptor	gnl\|CDD\|227113	COG4772, FecA, Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism].	0
CP023269.1\|AVJ22112.1\|2208634_2209585_+\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|226235	COG3712, FecR, periplasmic ferric-dicitrate binding protein FecR, regulates iron transport through sigma-19 [Inorganic ion transport and metabolism, Signal transduction mechanisms].	5.26599e-68
CP023269.1\|AVJ22109.1\|2204861_2206688_-\|glucoamylase	gnl\|CDD\|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	1.45949e-111
CP023269.1\|AVJ22104.1\|2200350_2200866_-\|RNA-polymerase-subunit-sigma	gnl\|CDD\|171561	PRK12528, PRK12528, RNA polymerase sigma factor; Provisional.	1.4929e-60
CP023269.1\|AVJ22097.1\|2189724_2191704_-\|lipopolysaccharide-biosynthesis-protein	gnl\|CDD\|225747	COG3206, GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane].	6.60853e-39
CP023269.1\|AVJ22096.1\|2188543_2189725_-\|glycosyl-transferase-family-1	gnl\|CDD\|340849	cd03822, GT4_mannosyltransferase-like, mannosyltransferases of glycosyltransferase family 4 and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.	1.29448e-71
CP023269.1\|AVJ22103.1\|2199413_2200364_-\|siderophore-interacting-protein	gnl\|CDD\|236622	PRK09774, PRK09774, fec operon regulator FecR; Reviewed.	2.5798e-81
CP023269.1\|AVJ22100.1\|2193495_2194956_-\|mannose-1-phosphate-guanylyltransferase/mannose-6-phosphate-isomerase	gnl\|CDD\|273648	TIGR01479, Mannose-1-phosphate_guanylyltransferase, mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase. This enzyme is known to be bifunctional, as both mannose-6-phosphate isomerase (EC 5.3.1.8) (PMI) and mannose-1-phosphate guanylyltransferase (EC 2.7.7.22) in Pseudomonas aeruginosa, Xanthomonas campestris, and Gluconacetobacter xylinus. The literature on the enzyme from E. coli attributes mannose-6-phosphate isomerase activity to an adjacent gene, but the present sequence has not been shown to lack the activity. The PMI domain is C-terminal. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	0
CP023269.1\|AVJ22101.1\|2194955_2196395_-\|undecaprenyl-phosphate-glucose-phosphotransferase	gnl\|CDD\|274396	TIGR03023, Sugar_transferase., Undecaprenyl-phosphate glucose phosphotransferase. This family of proteins encompasses the E. coli WcaJ protein involved in colanic acid biosynthesis, the Methylobacillus EpsB protein involved in methanolan biosynthesis, as well as the GumD protein involved in the biosynthesis of xanthan. All of these are closely related to the well-characterized WbaP (formerly RfbP) protein, which is the first enzyme in O-antigen biosynthesis in Salmonella typhimurium. The enzyme transfers galactose from UDP-galactose (NOTE: not glucose) to a polyprenyl carrier (utilizing the highly conserved C-terminal sugar transferase domain, pfam02397) a reaction which takes place at the cytoplasmic face of the inner membrane. The N-terminal hydrophobic domain is then believed to facilitate the "flippase" function of transferring the liposaccharide unit from the cytoplasmic face to the periplasmic face of the inner membrane. Most of these genes are found within large operons dedicated to the production of complex exopolysaccharides such as the enterobacterial O-antigen. Colanic acid biosynthesis utilizes a glucose-undecaprenyl carrier, knockout of EpsB abolishes incorporation of UDP-glucose into the lipid phase, and the C-terminal portion of GumD has been shown to be responsible for the glucosyl-1-transferase activity.	2.05031e-164

>CP023269.1|AVJ22105.1|2201034_2201664_+|lysine-transporter-LysE
MISLVTLGVFSGAVLLLLLSPGPNMAFVISQGVTHGWRGGVASALGIGVADLLLTALTAMGVTALVASWPPAFDLIRYAGVIYLLWLVFKTLQKRPGLGTAHVGRVALGRVFLQAMLNSLLNPKALLFFMVFLPQFVRPEAGPIALQLMVLGGVLTLIASVFHVLLGLFGGALSRFFAKRTKSAWLQKWGLAAVLMALAVRLAVMSRPA
>CP023269.1|AVJ22104.1|2200350_2200866_-|RNA-polymerase-subunit-sigma
MSSDHPLDPAAIGQLYQAHHSWLRGWLSRRTGCHERAADLAQDTFVRLLNARQQQTLQQPRAYLSSIARSLMIDQYRRRELERAYLESLAHFPQVEVPSEETKRLILDSLERIDRLLDQLKPRVREAFLLAQLDGLTCPQIALRLGVSKATVERDLSKALHACYRLRYADS
>CP023269.1|AVJ22103.1|2199413_2200364_-|siderophore-interacting-protein
MPTPDSRLVDQAIQWMIKLRYNTADDASTAAFDQWLHTSEAHQQAWQRVATLNDDFNHLPAHVSRHALDGARQHISRRESLKLLGLFAGAAGLAWLGRDYTPLPALMADYRTATGERRWVTLEDGSKVQLNSASAVDITSSAEQRLVNLRQGEILINTGADHRPLWVHTRDGYLRALGTRLLVREEPQGTLLAVQQGAVAVFADRHDSAARQVIKPGEQVMFNRSGIRPSPNNGLDPWAWSDGVISAHNMRLDDFLAELGRYRNGLVRCSEAVAGLRVSGTYQLDDTDQVLKLVAQSLAIDVTYRSRYWVTVSARV
>CP023269.1|AVJ22102.1|2196822_2199309_-|TonB-dependent-siderophore-receptor
MQAFPSLRLPLRHAIKATLLGACLAASTLPYSAGAQPPGGERQARSWNIAPGPLAGALDQFARQAGISVSYDAGSVAGKSSAGLSGALETQQALSRLLQGQGLQAQSQGPNAWLLLPQQAANSTLNLGATTITGERLGATTEGSGSYTTGAVTIGKGEHSLRQTPQSVSVMTRKLMDDQNITTIDQLLERTPGITSYESPMGGKYFYSRGFKMLGQYQFDGVPLDIGKDYIQADSFSANMAIYDRVEVLKGAAGMLKGAGTASGAVNFVRKRPQDKPTTSLGLSAGTWDNYHAEFDTGGPLNDSGTVRGRASVSQQNRGSYMDLAKRQDQAFYAALDMDISPDTTLGFGASYEDVDSTPCWSGLPRYRDGKSLGLSRSTCLGQAWNDWQSQRTTLFADVTHHFNDAWKLKVSAVHSRNLQDIKYAASESTVDYGNPAPTLTSYAALLDYDHKDYGLDAYIDGQFEAFGLQHELILGANGSRGTQDDVYAIRNLPQRQSVFNPNHHFPEPADDTFWPNMYRGGTVNETATQYGAYATLRLRLAEPLMLVLGSRVSWYENRRKSLNLAWGEWADQDARTKETGVVTPFAALIYDLNDNLSVYTSYADIFQPQSSYATVSGSALKPKMGENYELGIKGEWFDGRLNSSLAVFRAIEKNAAQTDFETRCGSSSDGYCYTDTGKVRAQGVEAELSGELLERLQVFGGYTYTQTKNLKNIDSAAEGAVSNTYVPRHMLRLWGDYQLDGALSKWTVGAGVNAQSSNYRLQTIKLEQAGYALWNARLAYQVDDTWTVALNGNNLFDKNYYQTVGTAGWGNLYGEPRNLTLSLKGNF
>CP023269.1|AVJ22101.1|2194955_2196395_-|undecaprenyl-phosphate-glucose-phosphotransferase
MRGKSSVDSLFLTRTGFVEFFVVFVKLLHGLTAISPAIILLFYPDPVAEHMRAHYLGLLAFFAILTIILFQALGVYSDDLFSNRLRFRVMLVAWVSAFCILLFMYQILLLFPQLSPRNLAFWFCASLLLFGLERILMLRLYRHLMDNGKFLQRTVILGFTDTAVHVAEHLSRNSDIRSGLIGFIDDRTERIPKELSRLPLLGNTRDLEKLIRSEQVNQVMITLPWAAEQRINGLVKRLRQMSVNVMLVPDMAALRYGHNRITDVGGILMFNTSQLPLRGWSPFIKRCEDLLLASIGLLLLSPVMLVTAIAIKLDSKGPVLFRQKRFGYNDNLIRVFKFRSMYVEQTDLNAENQTTRQDPRITRVGRIIRKTSIDELPQLFNVLLGNMSMVGPRPHATATKAAGIPFEEAVSEYSSRHRVKPGITGWAQINGYRGETDTLFKIQKRVEYDLEYIAKWSVWLDLYIVFMTVPAVLSTKEVY
>CP023269.1|AVJ22100.1|2193495_2194956_-|mannose-1-phosphate-guanylyltransferase/mannose-6-phosphate-isomerase
MNPLNGLIPCIISGGSGTRLWPVSRQNMPKPFMRMRDDQSLLQKTFLRASHLPGVDSILTVTNRDLLFRTLDDYRAVNTQRLGLDLLLEPFGRNTAAAIAVAALHVQEHFGADAQLLVMPADHLVLDEGAFAEAVEKARALAEAGYLVTFGIQPDRAETGFGYIEQGPALGAGFRVQRFVEKPDLATAQGYLDGGKHLWNGGMFCFKAATLLEELASHAPAVLEAAKAALEHSQSLQNSSSRQRELSPEGFASAPDISIDVALMEKSAQVAVVPCDIGWSDIGSWEALRQLTPSDDNGNQVNGEAILHDVQNCYIDSPKRVLGAVGVRDLIIVDTPDALLIADAHRSQDVRHIVAELKRQNHPAFSLHRTVTRPWGTYTVLEESTRFKIKRIVVKPKGSLSLQMHHHRSEHWVVVSGAAMITNGEREILLNMNESTYIPAGHKHRLTNPGIIDLVMIEVQSGEYLGEDDIVRYDDIYGRAPVEVKP
>CP023269.1|AVJ22099.1|2192584_2193496_-|glycosyl-transferase
MRTSLIIPTRNAASHLDRLLPALRMQTLQPDEMLVVDSASSDATVARFREFGARVERIDARDFNHGGTRRWASEQVGGDALIVMTQDAIPATAETFANLISELQLEPLNGVAYGRQLPHPGAGVLGAQSRHFNYPAASRTKRLDDAAQLGIKTCFSSDSFSVYRRSALSAVGGFPQDVIGSEDAYVAARMLLAGYQVRYAASAQVYHSHDYRLLEEFRRYFDIGVFYGREPWIRQAFGDAGGEGKRYVLAELHALREANALYRAPEVVVRSAFKLLGYRLGHLERHLPNALKRRLGMFSTYWT
>CP023269.1|AVJ22098.1|2191780_2192578_-|polysaccharide-biosynthesis-protein
MKTINRRSRLTLLGLLSASIWLAGCSTPARVPLPDNDTLKAGHQAALTLADLPPPQVLIQSGDSLRIVRDAQEPAAADDMTVFVVRPDGVISVPNIGRVKAALRTPEDLGKEITEKYKRIYREPAVTVNIASAPSNKVFIGGAVPNPAFFDLAGNVSVEQALLSSGGVLPSADASNVALLRTGPDGKYKTYFISLESMLTNPNQPRVALQRGDLIFVPQSGIGATVEAVDMYFTKLFPVSKGIGLGLNYQLNGNKSGDTYISAPQ
>CP023269.1|AVJ22097.1|2189724_2191704_-|lipopolysaccharide-biosynthesis-protein
MIEIRSLRDLLRLFFIYRREFKLAVITTIVVAVLGAFLLPARYESDARLLVKPGRDNTTLPIEAANRQTLIAPSTQHDPIVDEEKMLTGRPIVHIVAERYMAMTAEPPQGFWKVTKFYIKKGVGEVINGIRSVLQFVGLAEKQSPLERLATSLEKNFTAGHEPGSSVIEISFTWDDPAVAQKIVEEWVNAYLEERARILGRKSLHTFYETERAKVAENIQSLKDQLQGRLKQIDSISVDARLKNLTNQIDRVTDAKVSAQNQISGIRSLLANASQQIKSQPADVVTMRETSLNPTQLDLKRQLNALQVERARLLRTYLPGTPQVNQIEQNIRDMEALSAQEATRLERSQNTAPNSLVINVKQQMIDAQLQERKLAGEIENYDKTLAELRTQRDQAMTDEPQLNTLSQQLRTAEKSYALYSDNLEQARIDHELDNSQISNIALIEHATLNPARVFPKSLLMLLFAIPAGVAVGLLTIYVLYLLDQRIHDGTRLQEMFHVPLWSSIPDVQDATPAAVTASLYRLYSLLPLDRIAAEGFALGLTSARHGEGVTFIASQLKRLLEERGHRVSVDGANAPTPGEVLLLDASALSSNPQAFLTLRRADQIVLVIEARTSTVPTIENAVSLLTTAFGKVDGMILNRRRFEVPAKVLARLNSWRGAA
>CP023269.1|AVJ22096.1|2188543_2189725_-|glycosyl-transferase-family-1
MRIALLAPLPPEQTGIADYAAHLRNALIEQGLEVVTPLAGCLELPEQLKRLQAFDWRSVDLVHAELGGGRFGEFQALEYLRRAQPHLPLTATVHDPERLIWRRAKLFLPLTLLERLPHPLPQAAALLADPLTLHEERRLAKGMRRLITLTRLGGDCLRQRMGLRPQQVAVIAHGNLPIAPQALPPLAPLRLLYFGFIYRGKGIEDLLQALAQSLAAHPQCRGQVRLTLAGGTAPEMTFDPAGNYLDGLRQQISALHLEDVVDWQLDLPSAQIPSTIQAHHVMVLPYRESKKLSFLGQMRGTSGALSWANACGRGVITSNARAFAEEVAGGNGITYQQGDTASLSNALNRLILDPQQAQQWADRAGEIGRQRQWANTAQRFAELFRDACKEPLR
>CP023269.1|AVJ22106.1|2202238_2202919_-|dimethylglycine-dehydrogenase
MTLQIGFLLFPGIQQLDLTGPYDVLGSLPDVKLHLVWKDLAPITSSTGLVFTPTMTYADCPNLDVLCVPGGAGVGPLMEDPQTLDFLKAQAQTVRYMTSVCTGSLVLGAAGLLRGRKATTHWAYHHLLAPLGAIPVQERVVRDGNLFTGGGITAGIDFALTLAAELYSEAAAQLVQLQIEYAPAPPFDSGRPETAPRHVLEEANKRTVESRKVRGEIVARAAARLG
>CP023269.1|AVJ22107.1|2203008_2203977_+|AraC-family-transcriptional-regulator
MPKIIHVLAFENAQVLDVTGPLQVFASANDLARQHDLPLPYAVNVIAAQAEPVMTSSGLALLAEPLPAIDQPCDTLVIAGGWGVYGAAEDPALVQWVRDKSHYTRRMASVCTGAFLLAASGLLDGCRVATHWTRCEELARKFPALTVEANPIFIQQGAVWTSAGVTAGIDLCLALVEDDLGREIALEVARHLVVFLKRPGGQSQFSVTLSLQKSDSRFAELHAWIADHLTLDLSIATLAAQAGMSERSFVRHYRTETGQTPARAVELIRVENARRQLADSTTSIKRIARQCGFGCEETLRRSFLRALSVTPQAYRERFSPLQ
>CP023269.1|AVJ22108.1|2203962_2204874_-|alpha/beta-hydrolase
MATVTSPAPLLYVRTTLLDVAYETHGPIDGEPVILLHGFPYDPRGYDDIAPVLAERGYRVLVPYLRGYGPTRFINTQVMRSGQQAALAKDLLDFMDALSIPQATLAGFDWGGRAACIVAALWPQRVRGLVTGDGYNIQAISQSLKPRPPETEHRLWYQYYFHTQRGVDGLTANRRELCQLLWTLWSPSWAEGPSRYALTAPSFDNPDFVEVVIHSYRHRFMYAPGDPALEYIEQALEPQPPISVPSISLCGADDGVGPPSLEDDDVEHFSGFYRRQVLPGVGHNVFQEAPQVTLQALLELLER
>CP023269.1|AVJ22109.1|2204861_2206688_-|glucoamylase
MVDFKNEPQSAIDAHGIIGDMRSAALVNDRGSIDFFCWPEFDSPSVFCALLDTPEAGTFQLTPDLPNARREQIYLPDTNVLQTRWLSDEAVVEITDLLTVSENVDELPLLIRRVRVVSGKATIHLSCTVRHDYARAPTEANAEAASVVFTASGQPGLRLIGSQPLTLQGNTAIATFTLAQDEGAEFVLGGQEDARVTNDCTDLYLERTLKFWRGWISQSNYRGRWREMVNRSALALKLLTSRKHGAIIAAATFGLPETPGGERNWDYRYTWIRDASFTVYAFMRLGFVEEANAYMRWLRGRVSDCCGQPTKINILYGIDGRQELPETTLDHLSGHGGAQPVRVGNEAFDQIQLDIYGELMDAVYLVNKYGEAISHQGWKHTVEVVDQVCEIWNHKDVGIWEMRGEQHHFLHSRLMCWVALDRAIRLASKRSLPAPFARWDQTRQAIYADIWTNFWNEERGHFVQHTGSTALDGSMLLMPLVRFVAATDPRWLSTLEAIQKSLVRDGMVYRYRNDDSQIDGLQGVEGAFAACSFWYVECLARAGQVEKAHLEFEQLLRYANPLGLYAEEFDSQARHLGNTPQALSHLALISAATFLDRKLSGEKTVWQP
>CP023269.1|AVJ22110.1|2206680_2207481_-|sugar-dehydrogenase
MQISLQQQVALVTGASSGIGAGAAKALAAAGAAVVLNYNSQAAPTEALAAQINANGGRALAIGGDVSKEADVERLFEQTLDAFGHLDILVANSGLQKDANLVDMTLEDWNTVIGVNLTGQFLCARAAVRIFNRQGIREGVSRAAGKIIHMSSVHQVIPWAGHVNYAASKGGVEMLMRTLAQEVSEQRIRINGIAPGAIRTAINRAATEGAAEKELLKLIPYGRVGDVEDVANAVVWLASDASDYVVGSTLFIDGGMSLYPEFRGNG
>CP023269.1|AVJ25499.1|2207627_2208029_+|cytochrome-C
MHAWADTRWMKLLLSGVVAALSLAQTALCVAENSNGKALYLQRCAVCHGPDIKGTGPLAKKSNPPTPDLTTATFKKRFHDYPGVIVSSVILRPNGNLIPKTLQDNGVKIAPHAWSVKDFRDLHQYMSEIISNK
>CP023269.1|AVJ22111.1|2208107_2208608_+|RNA-polymerase-subunit-sigma-24
MTPQPPRRTGFFEHYEELIGTWTRRLRNRQQAEDLAHDTFVRVLESAACEVAQPRAYLHQTARNIAVDAYRREDRREALTLQAADHSTPHSSDPEHYMHAIQLADAIERALAELPLNCRRIFIWQKIEGLTQQEIATRLGLSKNMVEKYMIRTLRHLRDRLDASAP
>CP023269.1|AVJ22112.1|2208634_2209585_+|peptide-ABC-transporter-substrate-binding-protein
MDNRVRDEAAQWFVRLQDGPLSAQERQCFDAWRRSQPAHQYEIDVLQGLWSATDLLPKARLQALGDAPTERLGRRALLRYAVAASVVAVAVGLGAYSGLGQPKPYNAEFSTRLGEHRQVTLPDGSVMDLNSRSVVAVHYEKGRRGVELKQGEAMFSVQHDAGRPFVVAAGAGQVTVTGTRFDVRREADQTRVAVEAGTVKVQGRASDHIVTLTAGRGTHVDPQGQVAAAYAVNPEELTAWRNGKLVFNNATLVDVAREVSRYREQPLRVGTAAVGNLRLSSVFNSSDTDALLKALPHILPVALRTLPDGSQEIISR
>CP023269.1|AVJ22113.1|2209682_2212076_+|TonB-dependent-siderophore-receptor
MKKLAPHNNKISRWAPLALAVAISTAQAAEGIHIRAQSLGAALSQLGQQTSLQVFFSTDMVAGKQAPAVDGNLSPEQALRQLLQGSGLDYQIDAGSVTLRPVSRGTGEAGSPLELGVTDIKVVGDWLADADAEVVQNHPGARTVIRREAMVEQGAMNIGDVLRRVPGVQVQESNGTGGSDISLNVGVRGLTSRLSPRSTVLIDGVPAAFAPYGQPQLSMAPISAGNLESIDVVRGAGSVRYGPQNVGGVINFVTRAIPQDFSGEVGTTLQTSAHGGWKHVENAFIGGTADNGIGAALLYSGVNGNGYRNSNNGNDIDDVIFKTHWAPTDQDDFSLNFHYYDASADMPGGLTQKQFDANPYQSVRDWDNFSGRRKDVSFKYIRQIDDRTQAEVLTYYSDSFRGSNIANRDLKTLSSYPRTYYTFGIEPRVSHVFDLGPSTQEVNVGYRYLKEGMHEEATSLNLVNNVPTPGGQSDGHVYQDRTGGTEANAFYIDNKIDIGKWTITPGIRFEDIRTEWHDRPVVALNGKRTEEKRREVHNNEPLPALSVMYHVSDAWKLFANYETSFGSLQYFQLGQGGTGDQTANGLNPEKAKTYEVGTRYNDSVWGGEVTLFYIDFSDELQYVSNDVGWTNLGATKHSGIEASAHYDLSNLDPRLDGLTANAGFTYTKATSEGDVPFKGRDLPLYSRQVATLGLRYDVNHWTHNLDVYAQSGQRAPGTGTTYITQGSADGQYGDIPGYVSVNLRSGYDFGAQLSNLKLGVGVKNVFDQQHYTRSSDNNAGLYLGEPRTFFLQASVGF
>CP023269.1|AVJ22114.1|2212355_2212613_-|hypothetical-protein
MSAEAMTDPLLELAQQTLRPLRAVVTPMRVSRGGRHLRTTKYRPILVLPGLEINMGSILAIERTRSSSLVSDFDVDLGRWKVRRC

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Crispr_ID: CP023269_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023269_5

3206314-3206411

Orphan

Consensus_repeat	Method
CAATCCAACTGTGGGAGCTGGCTTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023269_5

>merge|CP023269|5|3206314-3206411|CRISPRCasFinder
CAATCCAACTGTGGGAGCTGGCTTGCCTGCGATGGCGGCCTATCAGCCGACACTTCTCTACCTGACACCCCACAATCCAACTGTGGGAGCGGGCTTGC

>CP023269|5|5|3206314-3206411|CRISPRCasFinder
CAATCCAACTGTGGGAGCTGGCTTGC	CTGCGATGGCGGCCTATCAGCCGACACTTCTCTACCTGACACCCCA
CAATCCAACTGTGGGAGCGGGCTTGC

Protein	Signature genes	Signature genes Name	Protein_function
CP023269.1\|AVJ22872.1\|3206529_3207893_-\|IS3-family-transposase	unknown	unknown	gnl\|CDD\|222853
CP023269.1\|AVJ22871.1\|3204879_3205863_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|227311
CP023269.1\|AVJ22864.1\|3196393_3197203_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117
CP023269.1\|AVJ22868.1\|3201102_3202674_+\|aldehyde-dehydrogenase-(NADP(+))	unknown	unknown	gnl\|CDD\|143447
CP023269.1\|AVJ22863.1\|3194176_3196240_-\|maltose-alpha-D-glucosyltransferase	unknown	unknown	gnl\|CDD\|131508
CP023269.1\|AVJ22870.1\|3203927_3204842_-\|ADP-ribosylglycohydrolase	unknown	unknown	gnl\|CDD\|377122
CP023269.1\|AVJ22862.1\|3193584_3194013_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377558
CP023269.1\|AVJ22875.1\|3209506_3210448_+\|aromatic-alcohol-reductase	unknown	unknown	gnl\|CDD\|187569
CP023269.1\|AVJ22878.1\|3214760_3215141_+\|fe2+-zn2+-uptake-regulation-protein	unknown	unknown	gnl\|CDD\|223806
CP023269.1\|AVJ22873.1\|3208229_3208838_-\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
CP023269.1\|AVJ22876.1\|3210884_3211694_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379548
CP023269.1\|AVJ22877.1\|3212242_3214522_-\|acylase	unknown	unknown	gnl\|CDD\|238911
CP023269.1\|AVJ22867.1\|3199991_3200939_+\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|223406
CP023269.1\|AVJ22880.1\|3215774_3216536_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
CP023269.1\|AVJ22879.1\|3215151_3215346_-\|hypothetical-protein	unknown	unknown	unknown
CP023269.1\|AVJ22865.1\|3197390_3199016_+\|aspartate:proton-symporter	unknown	unknown	gnl\|CDD\|223605
CP023269.1\|AVJ22881.1\|3216532_3217732_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270271
CP023269.1\|AVJ22874.1\|3208960_3209410_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
CP023269.1\|AVJ22869.1\|3202676_3203924_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
CP023269.1\|AVJ22866.1\|3199027_3199954_+\|hydroxyproline-2-epimerase	unknown	unknown	gnl\|CDD\|172473

Protein	Function_ID	Function_description	E-value
CP023269.1\|AVJ22872.1\|3206529_3207893_-\|IS3-family-transposase	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	3.24429e-48
CP023269.1\|AVJ22871.1\|3204879_3205863_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	5.30857e-98
CP023269.1\|AVJ22864.1\|3196393_3197203_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.69714e-29
CP023269.1\|AVJ22868.1\|3201102_3202674_+\|aldehyde-dehydrogenase-(NADP(+))	gnl\|CDD\|143447	cd07129, ALDH_KGSADH, Alpha-Ketoglutaric Semialdehyde Dehydrogenase. Alpha-Ketoglutaric Semialdehyde (KGSA) Dehydrogenase (KGSADH, EC 1.2.1.26) catalyzes the NAD(P)+-dependent conversion of KGSA to alpha-ketoglutarate. This CD contains such sequences as those seen in Azospirillum brasilense, KGSADH-II (D-glucarate/D-galactarate-inducible) and KGSADH-III (hydroxy-L-proline-inducible). Both show similar high substrate specificity for KGSA and different coenzyme specificity; KGSADH-II is NAD+-dependent and KGSADH-III is NADP+-dependent. Also included in this CD is the NADP(+)-dependent aldehyde dehydrogenase from Vibrio harveyi which catalyzes the oxidation of long-chain aliphatic aldehydes to acids.	0
CP023269.1\|AVJ22863.1\|3194176_3196240_-\|maltose-alpha-D-glucosyltransferase	gnl\|CDD\|131508	TIGR02455, trehalose_synthase_putative, trehalose synthase, Pseudomonas stutzeri type. Trehalose synthase catalyzes a one-step conversion of maltose to trehalose. This is an alternative to the OtsAB and TreYZ pathways. This family includes a characterized example from Pseudomonas stutzeri plus very closely related sequences from other Pseudomonads. Cutoff scores are set to find a more distantly related sequence from Desulfovibrio vulgaris, likely to be functionally equivalent, between trusted and noise limits. [Energy metabolism, Biosynthesis and degradation of polysaccharides, Cellular processes, Adaptations to atypical conditions].	0
CP023269.1\|AVJ22870.1\|3203927_3204842_-\|ADP-ribosylglycohydrolase	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.15439e-75
CP023269.1\|AVJ22862.1\|3193584_3194013_+\|hypothetical-protein	gnl\|CDD\|377558	pfam05818, TraT, Enterobacterial TraT complement resistance protein. The traT gene is one of the F factor transfer genes and encodes an outer membrane protein which is involved in interactions between an Escherichia coli and its surroundings.	0.000392912
CP023269.1\|AVJ22875.1\|3209506_3210448_+\|aromatic-alcohol-reductase	gnl\|CDD\|187569	cd05259, PCBER_SDR_a, phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs. PCBER and pinoresinol-lariciresinol reductases are NADPH-dependent aromatic alcohol reductases, and are atypical members of the SDR family. Other proteins in this subgroup are identified as eugenol synthase. These proteins contain an N-terminus characteristic of NAD(P)-binding proteins and a small C-terminal domain presumed to be involved in substrate binding, but they do not have the conserved active site Tyr residue typically found in SDRs. Numerous other members have unknown functions. The glycine rich NADP-binding motif in this subgroup is of 2 forms: GXGXXG and G[GA]XGXXG; it tends to be atypical compared with the forms generally seen in classical or extended SDRs. The usual SDR active site tetrad is not present, but a critical active site Lys at the usual SDR position has been identified in various members, though other charged and polar residues are found at this position in this subgroup. Atypical SDR-related proteins retain the Rossmann fold of the SDRs, but have limited sequence identity and generally lack the catalytic properties of the archetypical members. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.0285e-72
CP023269.1\|AVJ22878.1\|3214760_3215141_+\|fe2+-zn2+-uptake-regulation-protein	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	0.00586036
CP023269.1\|AVJ22873.1\|3208229_3208838_-\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.38022e-36
CP023269.1\|AVJ22876.1\|3210884_3211694_-\|hypothetical-protein	gnl\|CDD\|379548	pfam14302, DUF4377, Domain of unknown function (DUF4377). This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.	1.8953e-27
CP023269.1\|AVJ22877.1\|3212242_3214522_-\|acylase	gnl\|CDD\|238911	cd01936, Ntn_CA, Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-aminocephalosporanic acid (7-ACA), which can be used to synthesize semi-synthetic penicillins and cephalosporins, respectively. While both PGA and CA have a conserved Ntn (N-terminal nucleophile) hydrolase fold and the structural similarity at their active sites is very high, their sequence similarity to other Ntn's is low.	1.05778e-143
CP023269.1\|AVJ22867.1\|3199991_3200939_+\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|223406	COG0329, DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane].	1.09969e-64
CP023269.1\|AVJ22880.1\|3215774_3216536_-\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	1.76042e-61
CP023269.1\|AVJ22865.1\|3197390_3199016_+\|aspartate:proton-symporter	gnl\|CDD\|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	1.85552e-53
CP023269.1\|AVJ22881.1\|3216532_3217732_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270271	cd13553, PBP2_NrtA_CpmA_like, Substrate binding domain of ABC-type nitrate/bicarbonate transporters, a member of the type 2 periplasmic binding fold superfamily. This subfamily includes nitrate (NrtA) and bicarbonate (CmpA) receptors. These domains are found in eubacterial perisplamic-binding proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding their ligand with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. These binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.55676e-88
CP023269.1\|AVJ22874.1\|3208960_3209410_-\|transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	4.06893e-26
CP023269.1\|AVJ22869.1\|3202676_3203924_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	1.90415e-41
CP023269.1\|AVJ22866.1\|3199027_3199954_+\|hydroxyproline-2-epimerase	gnl\|CDD\|172473	PRK13970, PRK13970, 4-hydroxyproline epimerase.	8.98311e-152

>CP023269.1|AVJ22871.1|3204879_3205863_-|AraC-family-transcriptional-regulator
MQGKNLRYLSDNPQQSTSVTRVGFLLLEHFSLPAFTQTLDTLVTANLLRPDLFATRTFGWGEGEVISDLGLVIRPDANLMLAILQDLDLLVICGGFRTELKASEPFIQWLRSAGEAGVRLAGLWNGSWFLGRAGLLQGYRCAIHPEHRPALAEVSKAAQVTSEPYVIDRDRLTASSPSGAFHMALDWIKSLHGKALVEGIEDILAFEESRYRRIKPTENICVSAPLREVVKLMDANLEEPLELDQLAVYAGRSRRQLERLFKEQLGTTPQRYYMELRVTEARRLLQHTELSQVDVLVACGFVSPSHFSKCYSAYFGYRPSKEKRLVK
>CP023269.1|AVJ22870.1|3203927_3204842_-|ADP-ribosylglycohydrolase
MDITLLDRYRGSLLGLACGDAVGTTVEFMPRGSFSPVTDMLGGGPFSLKPGQWTDDTSMALCLAESLLRKGGFDAMDQMGRYLNWWKWGYLSSTGECFDIGMTVREALEQFQQSGNAFAGSTHPYSAGNGSMMRLAPVVLFYFPDRADINLFAEQSSRTTHAAHEAIECCLLLAEAISNALSGVPKKHVLSFSHTALSAPKVKAIASGDYRDKTSAQIVGSGYAVASLEAAFWCFDQTSNFAEAILAAANLGDDADTTAAIVGQLAGAYYGVQAIPVGWLNKLWMRDEIQETADALFSTSRLPQ
>CP023269.1|AVJ22869.1|3202676_3203924_+|FAD-dependent-oxidoreductase
MADPKQADIVVVGAGIIGVACALQLARQGRRVVVLDPQAPGMGASYGNAGHLATEQVFPIADLSILKRLPAMLLDPMGPLRLDWTYLPRALPWFIRLLLNLRPARYQRTVAGLRALNEGSLGAWQRLLQSMGQAQLLREDGSLLVFERAESRAALDALQHRMTQQGVAVDFWSGDAVRKAAPQLSDAIQGGLFFPATGHFLDPYTVVGELVNAAKAEGVQFLQQRVLDGRLEGSGVSLMTDQGVLTAQQVLIACGAHSAKLTAALTGRQVPLDTERGYHLMLPHEQQRLPFAVTSLERKFIMTPMTGGLRLAGTVEFAGLDRPANMQRAWQLHRLSKGLFRHELSDSEATPWMGFRPSLPDSLPIIDRVCEGKVLLAFGHQHLGLTQAAVTAERVGQLAAGERVPELQPYRLDRF
>CP023269.1|AVJ22868.1|3201102_3202674_+|aldehyde-dehydrogenase-(NADP(+))
MTLTGKMLIGQQSVCGHRDAIRAINPATNTPLEPAYAGGDEQHVDQACALAWAAFDAYRETTLADRATLLETIATHIEALGDELIERACAETGLPRARIEGERGRTCGQLRAFARTVRLGEWLDVRVDTAQPQRQPLPRADLRQRHIALGPVAVFGASNFPLAFSVAGGDTASALAAGCPVIVKAHNAHPGTSELVGRAVAQAVKDCGLPEGVFSLLYGAGNEMGIALVRHPRIKAVGFTGSRSGGIALCQAAQARPEPIPVYAEMSSINPVYLFPAALEARSEALTEGFVASLTQGAGQFCTNPGLMIALQGAALDRFIQSASERLSRCPSQTMLTPGIFSAYETGLKTLAQHAHIAAKGLPATGPNQGQAHLFVTQAEAFLDNEHLQAEVFGAASLVVQCRDVEQMRQVSEHLEGQLTATLHMDDHDLPQARALLPVLERKAGRLLVNGWPTGVEVCDAMVHGGPFPATSDARSTSVGTAAILRFLRPVCYQDFPDALQPTALHHDNPLQLRRLLDGQREA
>CP023269.1|AVJ22867.1|3199991_3200939_+|dihydrodipicolinate-synthase-family-protein
MSDNIFTGCMPALMTPCTAERQPDFDALVAKGRELIDIGMSAVVYCGSMGDWPLLTEAQRQEGVARLVAAGVPTIVGTGAVNSREAVSHAAHAANVGAHGLMVIPRVLSRGASVTAQKAHFAAILNAAPNLPAVIYNSPYYGFATRADLFFELRREHPNLIGFKEFGGAADLRYAAENITSQDDDVTLMVGVDTQVVHGFVNCNATGAITGIGNALPREVLQLVALSKKAAKGDAKARRQARELEAALAVLSSFDEGCDLVLYYKHLMVLNGDQGYALHFNETDGLSAAQRRYAEQQYALFRQWYANWSAEQNVA
>CP023269.1|AVJ22866.1|3199027_3199954_+|hydroxyproline-2-epimerase
MKRLHVIDSHTGGEPTRLVMSGFPALVGDTIADQLEHLRTHHDQWRRACLLEPRGNDVLVGALYCAPVTPGATCGVIFFNNAGYLGMCGHGTIGLVASLHHLGLIQPGVHSLDTPVGPVAATLHEDGSVTLRNVPAYRYRKQVPVEVPGHGVVLGDIAWGGNWFFLVSDHGHELQMDNVEALTDYTWAMLKALEAQGIRGADGALIDHIELFADDAHADSRNFVMCPGKAYDRSPCGTGTSAKLACLAADAKLAAGAPWVQASITGSQFLGRYEWDGERVRPFITGRAYMTADSTLLIDEQDPFAWGI
>CP023269.1|AVJ22865.1|3197390_3199016_+|aspartate:proton-symporter
MSGQGKFKKQLSLMDLTFIGLGAIFGSGWLFAASHVSAIAGPAGIFSWLLGGFAVLLLGIVYCELGAALPRAGGVVRYPVYSHGPLLGYLMGFITLIAFSSLVAIEVVASRQYAAAWFPQLTKAGSSDPTTLGWLVQFALLCLFFVLNYRSVKTFAIANNLVSVFKFIVPLLVIGVLFTFFKPENFQVHGFAPFGLSGIEMAVSAGGVIFAYLGLTPIISVASEVKNPQRTIPIALILSVLLSTAIYVLLQTAFLGGVPTEMLANGWAGISKELALPYRDIALALGVGWLAYLVVADAVISPSGCGNIYMNATPRVVYGWAQTGTFFKIFTRIDEKSGIPRPALWLTFGLSVFWTLPFPSWEALINVVSAALILSYAVAPVTVAALRRNAPDMARPFRVKGMAVLGPLSFIIAALIVYWSGWSTVSWLLGLQILMFVVYLLCARWVPTAHLNLKQQVRSSAWLIGFYAVTILLSKLGSFGGIGVISHPFDTLVVAACALGIYYWGAATGVPAHWVRLEQEEDESEAVSDAHYSAPLSPTTH
>CP023269.1|AVJ22864.1|3196393_3197203_-|AraC-family-transcriptional-regulator
MLQSAFASLFQGSRPHSIEQLLSGVEQLLPMLDVLPNAAIFIKDIDARYVLANRTLVQRCGLKQLQPLLGKTSAEVFPAQLGPGYTEQDRRVLKQGLVLEDQLELHLYGTREPGWCLTHKWPLYNQLGAIIGLAGISVDLQSASETHPAYQRLAAVDEHIRSHFNRRVTLGELTRIAGISVAQLERYCKRVFHLTPRQMIQKVRLEHARRLLHTELPITEVALQCGYTDHSAFTRQFKSSTGFTPRQYRQATQGGRPDENLMWEGACPR
>CP023269.1|AVJ22863.1|3194176_3196240_-|maltose-alpha-D-glucosyltransferase
MTAANNDHVNWLVQHSMLHAARQRAKLYSGQGRLWQQPYAQTRPRDASALSSVWFTAYPASIVTREGGTVLEALGDETLWHTLSKIGIQGIHNGPLKKSGGLSGTEHTPTIDGNFDRISFDIDPQLGTEAQLQALTRMAAAHNAVIIDDVIPSHTGKGADFRLAEMAYEDYPGLYHMVEIREEDWPLLPDVTAGRDAHNLSPSQVDALRDKHYIVGQLQRVIFFEPGVKETDWSATPVVLGVDGKPRRWVYLHYFKEGQPSLNWLDPSFAAQQMIIGDALHAIDVMGAKILRLDANGFLGVERKLDGTAWSESHPLSITGNQLLGGAIRKAGGFSFQELNLTVDDIASMSHGGADLSYDFITRPAYQHALLMGDTEFLRLMLRQMHSLGIDPGSLIHALQNHDELTLELVHFWTLHAHDSFLFQGQTFPGNILREHIREQMYERLTGEHAPYNLKFVTNGVSCTTASIITAALGIRDLEAITPADIQQIRQIHLLLVMYNAMQPGVFALSGWDLVGALPLAAEEVAHLMADGDTRWIHRGAYDLVDLNPEAELSAGQMPRSKSLYGSLNSQLQDPESFASQLQKILAVRRAYDIAASRQILVPDVEHPGLLIMVHELPAGKGTQITALNFGATPITETLHLPNIAPGPVVDIINERVEGDLTEEGAFTITLDAYEGLALRVVSSTPM
>CP023269.1|AVJ22862.1|3193584_3194013_+|hypothetical-protein
MKMTFPALALGILISQGALAAGDGTAALGGGVGGVLGNVVGQQLGGSTGAAIGAGVGGAAGSAVGAQKGNKTEAAIGGGLGSAGGSLIGNRLGGTTGSTIGAGVGGAAGGALGNNLADDESGHRSGGGKHKGNKHKHKNKHH
>CP023269.1|AVJ22872.1|3206529_3207893_-|IS3-family-transposase
MTKYNLALKQSLIEECLSASSVHEVALKHGLSPSLLRRWVKGFEKHGASGLIAKYSHYDAQFKLKVLQCIKQDGLSDQQACIRFDIRGPSSIRQWRKLYDEGGVEALQPHRLKESSMPRKPSRQPKASPALPADAELPPAQMLAELAYLRAENAYPKKARCLNPSGSPYCAAKKTQAVQGLRHEHPLALLLRAAALARSTFYYQSKTLLTDKHAGLKDRIRSVYHEHKGRYGYRRITATLGNSGELINHKKVYRLMQMIGLKSLVKVKKYRSYRGAEGLVAPDLLKREFKAQAPNQKWATDVTEFKVKGQKLFLSPLMDLYNGEILAYQINRRPEFKMVSTMLEKAFRRLNQGDRPILHSDQGWQYRQPTYRHMLAEKSIEQSMSRKGNCLDNAAMESFFGTLKSEFFYLESFESVEQLASGLEDYITYYNQDRISLRLNGLSPVQFRTQALNQ
>CP023269.1|AVJ22873.1|3208229_3208838_-|LysE-family-translocator
MIMSTSLLSAFVLFAFVSSITPGPNNTMLLASGVNFGFRRSMPHALGISIGFMLLVICVGLGLGEVFKLFPWAYTLLRYVGAAYLLYLAWKIANAGGMSDNPDEHGKPMTFLGAAAFQWVNPKAWIMALGAITTYTPAEGYVTNVLVIALVFAVVNLPSVCVWVGCGSGLRNLLREPRWLRMFNWSMAGLLVLSLYPMLFVG
>CP023269.1|AVJ22874.1|3208960_3209410_-|transcriptional-regulator
MTDQETLSQAEVICQSLREEDDGVRREVLAHAGSRWALGILHALGVYGAMRHAEIKRQMAGVTQRMLTKTLRAMERDGLLVRREFGEIPPRVEYELTPLGRELLIRMSPIWTWVVENVEDFRKARRIFDSQEGKKPAWQVPTPVPDAPR
>CP023269.1|AVJ22875.1|3209506_3210448_+|aromatic-alcohol-reductase
MPEMTPLPPQSILVLGAGELGLPVLRNLAREAKRAPGSTISVLLRDSTIKTQEPKKKAEVDELRSLGVHMVAADLINDSIDQLAKVFARFDTVIGCAGMVAGRETPMKLATAALKSGVKRYFPWQFGVDFEVIGRGSPQDLFDAQLDVRELLRAQDNTEWVIISTGMFTSFLFEPVFEVVDFDNNTVNALGSLENSVTLTTPDDIGTLTAQIVFFEPRMRNQIVYLAGDTVTYGQVASMLERVLDRPFKRNVWTVDYLMQALEKDPTHHIKKYRAVFAQGKGVAWPKAATFNEQQSIPVTTAEQWARENLAVH
>CP023269.1|AVJ22876.1|3210884_3211694_-|hypothetical-protein
MKQKILLVAVCAALIQGCAAPSKSHEESPSMPTTSAAVAQPTLSAYDWNLVSATDASGKPLVAMNKGIERKLRVAFGDKNLSISGGCNRQFGGFHYQDGVLKVQPLASTLMACDKSLMDLDAQVGRLFKGDLRAVITGDNVAPMLQLTTTDGSVLKLQGEATPQTRYGSEGEVKFLEVAAKTVKCSHPLIPDYQCLQVRERRYDDAGLQLATQDTWHPLYQPIEGFVHHDGVRTVLRVKQYEWKNPPADAPSTVYVLDMVVEQDASGSK
>CP023269.1|AVJ22877.1|3212242_3214522_-|acylase
MIISKGLSRVGATGLLLALSLAVSAREQVTQTSADIRRTSYGVPHIRASDERGLGVGMGYAYAQDNLCLLANEVVTVNGERARFFGPDQATLEERNNLASDVFFNWLNTPETVAAFWKAQTPEMQQRIEGYVAGYNRYLKDKGAPAQCQAAWVRPLVVQDLVKLTRRLLVEGGIGQFAEALVGAAPPQATASVQPGAKAFAMAAANQQRFTLDRGSNAVAVGRDRSFNGRGMLLANPHFPWVGGMRFYEMHLTIPGQLDVMGAALPGLPVVNIGFNQHVAWTHTVDTSKHFTLYRLTLDPKDATRYLLDGKSIPLDKTAVTVQVKQADGSLKAVTHTVYSSQFGPVVQWPGKLDWDSHYAFSLRDANLGNDRVLQQWYAMNRAGSLKELQTSVHTLQGIPWVNTLAADDQGQSLYMNLSVVPNVSAAKLAKCSDPRAGLQMIMLDGAHSACAWDIDPRAAQPGIFPADQLPQLQRTDYVQHSNDSAWMANPKAPLSGFSPVISQDNIGLGPRARFALQRLQTLEQQPITVTDLQDMVMDNEVYLAGQVMPDLLTFCAKHLGADAAALQPLCTSLKNWDQRANLDSGVGLVHFINLVQHLQQIPDAWRVAFDPAHPLTTPSGLAIDRAPVAKALRAAMLASSAEVSKLGQTRWGGIQVSGQTPIHGGPQELGIYNAMQTVPRADGKREVVSGTSYLQIVSFDDKGPNAVGVLAFSESSNPASAYSKDQTQAFSEKKLRPLPFTEAQIKADPHYQIHTVKE
>CP023269.1|AVJ22878.1|3214760_3215141_+|fe2+-zn2+-uptake-regulation-protein
MYNPQVPTDGHSKAADTHYGNDARAFGNAPEQQGNQRIRHLLKCFGLRTSLIRLKVIDALLTAADNQRPLGVRGVHSHLLELGIPLSFLSVREVLKRLCSEGVITLNADKSYSLHEEAAKVLEGRA
>CP023269.1|AVJ22879.1|3215151_3215346_-|hypothetical-protein
MTQKQRLKYSLLIALAVLGAMFGLSYLQNTGVISEKTFQYLAIAIAVVVVVINGIMRRKVKPNF
>CP023269.1|AVJ22880.1|3215774_3216536_-|ABC-transporter-permease
MNNSRIPGWWLGLSGLAGLLVLWWLGVKVFGEADGLSARFSLAATASSLWELLGRGELYLHIAVSLKRIFVGLFIALLVGVPLGLLVGSSRNLEAATTPAFQFLRMISPLSWMPIVVMLMGVGDQPIYFLLAFAAVWPIMLNTAAGVRQLDPRWLQLSKSLSATRWETLRRVVIPGVVGHVLTGVRLAIGILWIVLVPCEMLGVSAGLGYYILDTRDRLAYSELMAMVVVIGVLGFALDAFARWLHRRWVHGG
>CP023269.1|AVJ22881.1|3216532_3217732_-|ABC-transporter-substrate-binding-protein
MCLDDLAHSRRDFLKLSAVLSAAGALPLLSSLQARAANEPDAPVRIGYLPITDATPLLVAHNNGLFEAEGIKAERPVLLRSWAQVIEAFISGQVNVIHLLSPMTVWARYGSKVPAKVVAWNHVGGSGLTVSPGITDVKQLGGKSVAIPFWYSIHNVVVQQLFRDNGLTPVTRATGSSIAANEVNLIVLPPSDMPPALASKRIDGYIVAEPFNALAENLKVGRVQRFTGDVWRNHACCVVFMHEHDLANRPEWSQKVVNAIVKAQVWTRNNREEAVKLLSKDGPNRYTPHAEPVLSKVLAPAASDRATYVADGAIQHANWDEHRIDFQPYPFPSYTEELVRRLKDTLIEGDKKFLTGLDPAFVAKDLVDDRFVRNAIEAVGGMQTFGLPDGYERHEEIGV

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Crispr_ID: CP023269_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023269_6

3289302-3289396

Orphan

Consensus_repeat	Method
GGCAAGCCAGCTCCCACATTTAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023269_6

>merge|CP023269|6|3289302-3289396|CRISPRCasFinder
GGCAAGCCAGCTCCCACATTTAGATCCCGGAGCATCAGGTAGATTGGTGCCGGCTGTCGGGCCGCCATAGGTGGCAAGCCAGCTCCCACATTTTG

>CP023269|6|6|3289302-3289396|CRISPRCasFinder
GGCAAGCCAGCTCCCACATTTAG	ATCCCGGAGCATCAGGTAGATTGGTGCCGGCTGTCGGGCCGCCATAGGT
GGCAAGCCAGCTCCCACATTTTG

Protein	Signature genes	Signature genes Name	Protein_function
CP023269.1\|AVJ22942.1\|3286652_3286967_-\|DUF2834-domain-containing-protein	unknown	unknown	unknown
CP023269.1\|AVJ22943.1\|3287158_3288868_+\|amidase	unknown	unknown	gnl\|CDD\|180626
CP023269.1\|AVJ22952.1\|3297719_3298703_-\|C4-dicarboxylate-ABC-transporter	unknown	unknown	gnl\|CDD\|270392
CP023269.1\|AVJ22953.1\|3298921_3299737_-\|CoA-ester-lyase	unknown	unknown	gnl\|CDD\|225184
CP023269.1\|AVJ22951.1\|3296947_3297580_-\|C4-dicarboxylate-ABC-transporter	unknown	unknown	gnl\|CDD\|225632
CP023269.1\|AVJ22947.1\|3292330_3293218_+\|dienelactone-hydrolase	unknown	unknown	gnl\|CDD\|223489
CP023269.1\|AVJ22949.1\|3294331_3295474_+\|class-C-beta-lactamase	unknown	unknown	gnl\|CDD\|236894
CP023269.1\|AVJ22950.1\|3295667_3296948_-\|TRAP-transporter-large-permease	unknown	unknown	gnl\|CDD\|224509
CP023269.1\|AVJ22934.1\|3277104_3278508_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340877
CP023269.1\|AVJ22937.1\|3281036_3281960_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|377694
CP023269.1\|AVJ22941.1\|3285249_3286461_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341031
CP023269.1\|AVJ22935.1\|3278999_3280502_+\|proline/glycine-betaine-transporter-ProP	unknown	unknown	gnl\|CDD\|182611
CP023269.1\|AVJ22940.1\|3284325_3285147_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380379
CP023269.1\|AVJ22938.1\|3282123_3283146_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223999
CP023269.1\|AVJ22939.1\|3283142_3284333_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
CP023269.1\|AVJ22944.1\|3289434_3290760_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224089
CP023269.1\|AVJ22936.1\|3280555_3281062_+\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|376570
CP023269.1\|AVJ22946.1\|3291791_3292286_+\|thioesterase	unknown	unknown	gnl\|CDD\|239527
CP023269.1\|AVJ22945.1\|3290849_3291740_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|223769
CP023269.1\|AVJ22948.1\|3293329_3294202_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176173

Protein	Function_ID	Function_description	E-value
CP023269.1\|AVJ22943.1\|3287158_3288868_+\|amidase	gnl\|CDD\|180626	PRK06565, PRK06565, amidase; Validated.	0
CP023269.1\|AVJ22952.1\|3297719_3298703_-\|C4-dicarboxylate-ABC-transporter	gnl\|CDD\|270392	cd13674, PBP2_TRAP_SBP_like_1, Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic transporter family; the type 2 periplasmic-binding protein fold. This subfamily includes uncharacterized periplasmic substrate-binding proteins similar to TRAP transport systems such as SiaP (a sialic acid binding virulence factor) and TeaA (an ectoine binding protein). TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	4.10615e-151
CP023269.1\|AVJ22953.1\|3298921_3299737_-\|CoA-ester-lyase	gnl\|CDD\|225184	COG2301, CitE, Citrate lyase beta subunit [Carbohydrate transport and metabolism].	4.39551e-68
CP023269.1\|AVJ22951.1\|3296947_3297580_-\|C4-dicarboxylate-ABC-transporter	gnl\|CDD\|225632	COG3090, DctM, TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism].	5.12744e-28
CP023269.1\|AVJ22947.1\|3292330_3293218_+\|dienelactone-hydrolase	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	9.39372e-64
CP023269.1\|AVJ22949.1\|3294331_3295474_+\|class-C-beta-lactamase	gnl\|CDD\|236894	PRK11289, ampC, beta-lactamase/D-alanine carboxypeptidase; Provisional.	0
CP023269.1\|AVJ22950.1\|3295667_3296948_-\|TRAP-transporter-large-permease	gnl\|CDD\|224509	COG1593, DctQ, TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism].	2.48347e-141
CP023269.1\|AVJ22934.1\|3277104_3278508_-\|MFS-transporter	gnl\|CDD\|340877	cd17319, MFS_ExuT_GudP_like, Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily. This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.6447e-71
CP023269.1\|AVJ22937.1\|3281036_3281960_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|377694	pfam06719, AraC_N, AraC-type transcriptional regulator N-terminus. This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.	7.63961e-60
CP023269.1\|AVJ22941.1\|3285249_3286461_+\|MFS-transporter	gnl\|CDD\|341031	cd17478, MFS_FsR, Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters. Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.51712e-104
CP023269.1\|AVJ22935.1\|3278999_3280502_+\|proline/glycine-betaine-transporter-ProP	gnl\|CDD\|182611	PRK10642, PRK10642, proline/glycine betaine transporter ProP.	0
CP023269.1\|AVJ22940.1\|3284325_3285147_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|380379	cd06124, cupin_NimR-like_N, AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain. This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	9.68606e-35
CP023269.1\|AVJ22938.1\|3282123_3283146_+\|hypothetical-protein	gnl\|CDD\|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	2.38141e-38
CP023269.1\|AVJ22939.1\|3283142_3284333_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	2.45288e-92
CP023269.1\|AVJ22944.1\|3289434_3290760_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	6.39008e-102
CP023269.1\|AVJ22936.1\|3280555_3281062_+\|GAF-domain-containing-protein	gnl\|CDD\|376570	pfam01590, GAF, GAF domain. This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyze ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalyzed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyzes the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.	1.61182e-05
CP023269.1\|AVJ22946.1\|3291791_3292286_+\|thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	2.97265e-06
CP023269.1\|AVJ22945.1\|3290849_3291740_+\|EamA-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	2.38098e-10
CP023269.1\|AVJ22948.1\|3293329_3294202_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176173	cd08484, PBP2_LTTR_beta_lactamase, The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LysR-type transcriptional regulators, BlaA and AmpR, that are involved in control of the expression of beta-lactamase genes. Beta-lactamases are responsible for bacterial resistance to beta-lactam antibiotics such as penicillins. BlaA (a constitutive class A penicillinase) belongs to the LysR family of transcriptional regulators, while BlaB (an inducible class C cephalosporinase or AmpC) can be referred to as a penicillin-binding protein, but it does not act as a beta-lactamase. AmpR regulates the expression of beta-lactamases in many enterobacterial strains and many other gram-negative bacilli. In contrast to BlaA, AmpR acts an activator only in the presence of the beta-lactam inducer. In the absence of the inducer, AmpR acts as a repressor. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.54196e-111

>CP023269.1|AVJ22943.1|3287158_3288868_+|amidase
MMQVTEVSIAQLRAALEAGQTTAVELVQAYLARIDAYDGPQTATALNAVVVRNPDALKEAQASDARRAKGQTLGPLDGIPYTAKDSYLVKGLTAASGSPAFAKLVAQRDAFTIERLRAGGAICLGKTNMPPMANGGMQRGVYGRAESPYNADYLTAPFASGSSNGAGTATAASFAAFGLAEETWSSGRGPASNNGLCAYTPSRGVISVRGNWPLTPTMDVVVPYARTMADLLEVLDVVVAEDPDTRGDLWRLQPWVPIPSVTSVRPVSYAALAVDSENLAGKRFGVPRMYINADPDAGTSEKPGIGGPTGQKIHTRATVIELWQAARQALEAAGAEVIEVDFPLVSNCEGDRPGAPTVFTRGLVSKEFLHDELWELSAWAFDDFLRANGDPHLNRLADVDGPNIFPHDPGTLPNREDDLAAGMDEYVRMAQRGITPWDQISTVPDGLRGLEQTRRLDLEDWMDTLGLDAVLFPTVADVGPADADVNEASADIAWSNGVWVANGNLAIRHLGVPTVTVPMGVMADIGMPVGLTFAGRAYDDSALLRFASAFEATGSKRMIPPRTPPLAAR
>CP023269.1|AVJ22942.1|3286652_3286967_-|DUF2834-domain-containing-protein
MHRPYIALAALLGFTLYTVATMLTAEQSLLAFGWELMSRPDTAQVVIDLYLMAVLACVWMYRDARGRGRSMVSVLPYFLLTAVFVSVGPLLYIVVNGFSRRAMK
>CP023269.1|AVJ22941.1|3285249_3286461_+|MFS-transporter
MSTVTASPAAPSTSPQVSPLVMRVLGACALAHLINDLIQAVLPSIYPMLKANYGLSFTQVGLITLTFQLTASLLQPWIGYHTDRHPKPWLLPAGMVCTLIGILMLAFVGNFPAILLAAALVGVGSSTFHPETSRVARLASGGRYGLAQSTFQVGGNTGSAFGPLLAAAIIIPYGQSHIAWFGLFAVFAILVLYGLSRWYRHHLNLFKLKQGSQATHGLSKGRVTFALVVLAVLVFSKYWYMTSLTSYFTFYLIEKFQLSVASSQMYLFLFLGAVAVGTFAGGPIGDKIGRKKVIWFSILGAAPFTLALPYVDLFWTAVLSVVIGFIIASAFSAIVVFAQELVPGNVGMIAGIFFGLMFGFSGIGAALLGMLADHHGIEYVYKLCSFLPLVGILTVLLPSTKGV
>CP023269.1|AVJ22940.1|3284325_3285147_-|AraC-family-transcriptional-regulator
MPVSRNSGGNHRKKGEMIKSLDKFLREIDEGDWAVISSATDYPENWVIPEHSHNKHQLLYAIGGVMVVYSALRQWTVPPNRGFWMPCGQVHSLRCVGTLKMRSVFVRPDSFPNLPAEPKTVTVSPLLSELIKASVSLKPPYAEDSRDARIMHLILDELAILPALPLSLPQPADPRLRPICLALQDEPSDASTVADWSARLGLDQTTIQRLFRKETGMTFGQWRQQARLLLALERIAVGEKIIDVAFELGYESPSAFTSMFKKQFGKTPSHFFK
>CP023269.1|AVJ22939.1|3283142_3284333_+|MFS-transporter
MSSVTPQPQRWGAVLAMSLAAFALVASEFMPVSLLTPLAADLHITEGQAGQGISVSGVFALLTSLVIAAVAARMDRKRLLMALTLLMIVSGSVVAFAPNYAVFMLGRALIGAAIGGFWSLSAATAMRLVEPAQVPRALAIVNGGNALATVIAAPLGSFLGGLIGWRGAFFCVVPVAVIALAWLWLSLPALKHSGTAATGNALRLLKNAKVALGMCAVSLFFMGQFMLFTYLRPFLEGVTRVEVSTLSLMLLVLGLAGLAGTVLIEHLLKRHLYPTLIAIPLIMAGIALALVGFGGSAIVTTLLLGCWGLVATAAPVGWWTWLARTLPDDAEAGGGLMVAIIQLAIAAGATVGGVAFDLSGYRATFELSAALLVVATLLAYLASRRPAHAPMASDAT
>CP023269.1|AVJ22938.1|3282123_3283146_+|hypothetical-protein
MKRLLLALGLLVTSLSSFGADMSNGADNFYNSDTVTAEPVTFNNQYGMQVAGTLFMPRHLAPGSKHAALVVGHPMGAVKEQSANLYATKMAEQGFVTLSLDLSFWGQSAGTPRNAVLPDLYVEDFSAAVDFLGTRPQVDRERIGAIGICGSGSFVISAAKIDPRLKAIATVSMYDMGAANRNGLKHGMTLQQRQQILRQAANQRYVEFQGGETLYTGGTPQSLTGDPVGDEFYDFYRTPRGEVTPAGASSQTTTRPTLTSNVKFMNFYPFNDIETISPRPLLLITGANAHSREFSEDAYQRAAEPKQLLIIPNAGHVDLYDRVELIPFDTLTTFFQSHLQ
>CP023269.1|AVJ22937.1|3281036_3281960_-|AraC-family-transcriptional-regulator
MTSTLTPLNALIQSIGSRTPSPGDYAMSIPGLGFYRREQPAAPVVCMVEPCIVLVAQGEKQLWVGGEGFPYDPSRFLVTSLDIPANSEVLAASPEQPCLGLTFKLDLRMLAELIAQSGLPPVRERAVMKGVGIGTVTDGMLAAFARLVALLDEPEAIPVLAPLIQREIHYRLLKSDQAGRLRQICSVDGQGYRIAKAIDWLKLNFDAVLRVEELAARVQMSAATFHHHFRQLTAMSPLQYQKWLRLNEARRLMLNEHQDVSSAAFKVGYESPSQFSREYSRLFGVPPKRDMATLRGRAGVSDPQGSD
>CP023269.1|AVJ22936.1|3280555_3281062_+|GAF-domain-containing-protein
MVSSVTAAHRLLSADERAAIAEIEATTNILKLVTRLTGMRFAGIAKFTDLEWVVCSAYDPLQMGINVDDVLDLETTLCSEFCINPHTLFIPQISQNGRFASRPVVKQYAIESYAGAPIFLPDGRLFGALCALDSRAMLFDDPNLPETLSLFARLIGCIFYANLTPADH
>CP023269.1|AVJ22935.1|3278999_3280502_+|proline/glycine-betaine-transporter-ProP
MKLRKKRVKPIGLKDITIVDDNKMRKAITAAALGNAMEWFDFGVYGFVAYVLGKVFFPDASPSVQMIAALATFSVPFLIRPLGGLFFGALGDKYGRQKVLAATIVIMSLSTFAIGLIPGYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYAPDRKRGFLGSWLDFGSIAGFVLGAGVVVLISTVLGEAEFEAWGWRLPFFLALPLGIIGLYLRHALEETPAFQQHVDKLEQGDREGLSHGPKVSFKEIATKHWRSLLTCIGIVAATNVTYYMLLTYMPSYLSHNLHYAENSGVLIIIAIMVGMLFVQPFIGFVSDKIGRKPFIIAGSIGLLFLSIPAFMLITSGKTGLIFGGLLILAVVLNFFIGVMASTLPAMFPTHLRYSALASAFNVSVLIAGVTPTAVAWLVESTNDLYMPAYYLMVFAVVGLITGLTMKETANKPLRGAAPAASDMEEAKELLQEHHDNIEQKIEDIDAEIAALQTKRENLVQQHPRIN
>CP023269.1|AVJ22934.1|3277104_3278508_-|MFS-transporter
MNLNEPISALRVGQAVGSYRWTICAMLFFATTVNYLDRQVLSLLAPQLSTQFGWSNTDYANIAAVFQFVYAISMLFAGRFVDRIGTKAAYVVAIGIWSTGAIMHAFSVPMGEGIAAVSGAIGLAVIPVSIAGFMLSRAVLAIGEAGNFPIAIKATAEYFPKKERSLATGIFNSGANVGAILAPICVPLIAGMWGWEAAFMVIGMLGFVWVAVWAAVYEKPEQQKRLSPEELAYIRSDQTVQPFTPAPTGTVGKKVSWFKLLTYRQTWAFAFGKFMTDGVWWFFLFWLPTYLSAQYGMKGADIVMPLAVLYSMTMVGSIGGGWFPSYFMARGDAPYDGRMKAMLVIALFPLVVLLAQPLGYLSFWVPVLLIGVGASAHQAWSCNIFTTVSDMFPQKTVASVVGIGGMAGGLGGVLMTKIGGWVFDYYKSINDIHTGYMIMFAVCALAYLVAWSVMKTLVPRHKEITDL
>CP023269.1|AVJ22944.1|3289434_3290760_-|GntR-family-transcriptional-regulator
MPRARYKTLVDTFAEAIRSGQLQPGTRLPTHRHLAAEHGLALVTASRVYSELEAMGLVSGETGRGTFVREIALPAGQGSGQMTVAAGVLDLNFNYPSLPGQAELLRTALRQLALSGDLEALLRYQPHAGRVHERAAVARHLLNRGLTVQAEQVLVVSGAQHGLAVSMMTLLKPGDVVAVDALTYSGFKVLAETLHLELVAIPVTANGPNLDHLHSLCRQRPVRAVYSMPTLHNPLGWVMSLAQRERLVAIARQHKLMIIEDGAYAFLAEEAPPPLATLAPERTVYIGGLSKSVATGLRVGFIAAPMAWVSGLERTIMATTWNVPGVMSAIAVGWLEDGTVTQLEAQKRADAQARQALAAQVLRGVKTISHPSSYFLWLPLAEDARADQVAMTLQRAGISVSTAEPFAISAQVPHALRLALGSVPMAALREALVTVRKVVAW
>CP023269.1|AVJ22945.1|3290849_3291740_+|EamA-family-transporter
MERTSPLGTLDSSTQGWINGFIGVVIFSGSLPATRLAVMEFDPVFLTMIRASLAALLGLCLLGVFKEKRPTRQQWAPLVIVALGVVIGFPLLTALALQYVTSAHSIVFIGLLPLATAVFGVLRGGERPRPVFWLFSILGSLLVMGYAVAQGLSAAPAGDVLMLLAVLACGLGYAEGAKLSRSLGGWQVICWALVVSLPVVAPLSLLLAPSTLSGISLPAWLSLGYVAVFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLALAVGLLHEQVSLGMVLVTVAVIGCVAGAKKFAR
>CP023269.1|AVJ22946.1|3291791_3292286_+|thioesterase
MHSASLQDTTAPEGICYGCGSSNPHGLHIKSRWDDDGVHVIAEHQPEAKYSGWPDLVYGGLIAMLVDCHSNWTAMAYHYRAEQREPGSLPRIDCVTGNLGIKFIKPTPMGVPLVLRARVEGEIGRKSRVVCEVYAGSVLTAVGDSVFVRVDTGQLAAAAHGREV
>CP023269.1|AVJ22947.1|3292330_3293218_+|dienelactone-hydrolase
MTRLTAKDFAPELLELYDGYAHGKINRREFLDRAALFTLGGLTASALLAALSPNYALAEQVKFTDPDIVADYITYPSPKGNGTVRGYLVRPAKAAGKLPAVVVVHENRGLNPYIEDVARRLAKAGFIALAPDGLTSVGGYPGNDEKGVALQQTVDPTKLMNDFFAAIEWLMQHDSSTGKVGITGFCYGGGVTNAAAVAYPELGAAVSFYGRQPDAKDVPRIKAPIMLHFGELDTRINEGWPAYEQALKAAGTRYEAFIYKGANHGFHNDSTPRYDEAAANLAWERTLGWFRQYLA
>CP023269.1|AVJ22948.1|3293329_3294202_-|LysR-family-transcriptional-regulator
MLRSHLPLNALRAFEASARHLSFTRAAIELCVTQAAVSHQVKSLEAQLNVTLFKRLPRGLMLTSEGESLLPVLRDAFDRIALTLDQFEGGHYREVLTVGAVGTFAVGWLLPRLADFHSRYPLIDLRLSTHNNRVDVAAEGLDYAIRFGAGAWHGTDACALLEAPLTVLCVPQIAEQLHSPADVLKHTLLRSYRADEWNLWFQAAGLPSDTRMPRSVVFDSSLAMMEAALQGTGVALAPALMFSRQLENDVIRQPFEVGITTGSYWLTRLQSRAETPAMLAFKGWLQASVA
>CP023269.1|AVJ22949.1|3294331_3295474_+|class-C-beta-lactamase
MKHTLKKYAVSALLLGAGSCMAATDMRQVVDSHVTPLMKQQGIPGLTVAVVQHGKVQYFNYGVAAKDTQVPVTENTLFEIGSVSKTFNATLGGYAQAIGKLKLSDMTSQHLPVLAGSAFDRISLLQLATYTAGGLTLQFPDAADSATTMMDYFQHWKPTYAPGEQRLYSNPSIGLFGYVTAKSLGQPFTVAMEKTLLPKLGLTNTYTRVPADKAGQYAQGYDSQQKPVRVNPGALDFEAYGIKSSSQDLARYVIANMHPQTLEQPVQQAIATTHAGYYTVNGMTQGLGWERYPYPISLQALLDGNSTPMAMEPHKVTWLKPAQPQPANVLYNKTGSTGGFGAYVAYVPSKDMGVVILANRNYPNAERVKVAHAILSAMDQ
>CP023269.1|AVJ22950.1|3295667_3296948_-|TRAP-transporter-large-permease
MAVLCLFLLLFVFMFLGVPIAIALGLSGAVSILMFSQDSVSSLAIKLFETSDAYTFLAIPFFLLSGAFMTTGGVAQRLIDFANACVGHIRGGLAIAAVLACMLFAALSGSSPATVAAVGSIAVAGMVRSGYPKEFGAGIICNAGTLGILIPPSIVMVVYSAATETSVGKLFMAGVIPGLLLGLMLMVAIYIVARIKKLPAQPRATFREWLSCARRAFWGLLLLVIILGGIYSGMFTPTEAAAVAAVYSAFVALFVYKDMKLRDCPKVLLESGRLSIMLMFIIANAMLFAHVLTTEQIPQQITAWVISEGLTPIGFLIMVNVVLLIAGSFMEPSAIVLILAPIFFPIAMKLGIDPIHLGIVMVVNMEIGLVHPPVGLNLFVTSAVTGLTLGQTIRAAMPWLMILLVFLIMVTYLPFISLALPQWLGM
>CP023269.1|AVJ22951.1|3296947_3297580_-|C4-dicarboxylate-ABC-transporter
MQTLRRVWEHLEEAFIAFLLAAMTLVTFVYVMLNNVYTLFFALADKWAWSSAFFNALGDGTMTWAQEMTWSVALTKAMFGWLIFFGISYGVRTAGHLGVDALVRLTRRPVQRLLGMLACLCCLAYAGLFMVASYKWVSAVMTAHIGAEDLDQFGIDVGDIVVIVPIGFALVLIRYLEIFYRIFTHRQVGLGLADEAGEASKLAGSHEERH
>CP023269.1|AVJ22952.1|3297719_3298703_-|C4-dicarboxylate-ABC-transporter
MLKLSRALLCAATLFTAGLAQAADPIVIKFAHVVAENTPKGQGALLFKKLAEERLPGKVKVEVYPNSSLFGDGKEMEALLLGDVQMLAPSLAKFEHYTKQVQIYDLPFLFNDLAAVDRFQAAQGKQLLTSMQDKNILGLAYWHNGLKQLSANKALHEPKDARGLKFRVQASSVLEEQFKAIRANPRKMSFAEVYQGLQTGTVNGTENTWSNYESQKVNEVQKYFTESNHGLIDYMVITNATFWNGLAPDVRSTLEQIMAEVTVEVNKQAEALNQSAKQKIIDAKTSEIIELTPEQRALWREAMRPVWQKFEGEIGADLIKAADASNQ
>CP023269.1|AVJ22953.1|3298921_3299737_-|CoA-ester-lyase
MPKPLVRSALFVPGSRPERFAKALASGADAVIVDFEDAVEEPLKRQARDNLDAFLRAHPEAQLWVRINAPQHAEHFEDVAFCKAHANVAGVLLPKVESAAQVAVVAATGKAIWPIIESARGLLALAQIAQAPQVERLSFGGLDLALDLNLSSHSRAAELALDQARLALIVHSRAAGLAAPLDGVHPAIDDPEGLHRSIRHAYEMGFAGALCIHPKQVAVIHAALAPSAQELAWARRVVEAGAHGAGAYQIDGQMVDAPVLLRAQRLLAAQL

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Crispr_ID: CP023269_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023269_7

3501998-3502099

Orphan

Consensus_repeat	Method
ATCGCAGGCAAGCCAGCTCCCACAGTTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023269_7

>merge|CP023269|7|3501998-3502099|CRISPRCasFinder
ATCGCAGGCAAGCCAGCTCCCACAGTTGGATTGCGGGGGTGTCTGGTAGGTAAATGTCGGCTGGCAGGCCGTCATCGCAGGCAAGCCAGCTCCCACATTGGG

>CP023269|7|7|3501998-3502099|CRISPRCasFinder
ATCGCAGGCAAGCCAGCTCCCACAGTTGG	ATTGCGGGGGTGTCTGGTAGGTAAATGTCGGCTGGCAGGCCGTC
ATCGCAGGCAAGCCAGCTCCCACATTGGG

Protein	Signature genes	Signature genes Name	Protein_function
CP023269.1\|AVJ23102.1\|3497564_3498152_-\|GDP-mannose-pyrophosphatase	unknown	unknown	gnl\|CDD\|184971
CP023269.1\|AVJ23098.1\|3491085_3494157_-\|error-prone-DNA-polymerase	unknown	unknown	gnl\|CDD\|235553
CP023269.1\|AVJ23101.1\|3496351_3496969_-\|repressor-LexA	unknown	unknown	gnl\|CDD\|171489
CP023269.1\|AVJ23099.1\|3494314_3495730_-\|DNA-repair-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|176458
CP023269.1\|AVJ23096.1\|3486755_3489275_-\|excinuclease-ABC-subunit-A	unknown	unknown	gnl\|CDD\|223256
CP023269.1\|AVJ23112.1\|3508177_3508498_-\|hypothetical-protein	unknown	unknown	unknown
CP023269.1\|AVJ23114.1\|3509283_3509730_-\|protein-TolR	unknown	unknown	gnl\|CDD\|274306
CP023269.1\|AVJ23097.1\|3489271_3490984_-\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|237425
CP023269.1\|AVJ23110.1\|3505533_3506508_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270276
CP023269.1\|AVJ23109.1\|3503867_3505451_+\|sulfurtransferase	unknown	unknown	gnl\|CDD\|238793
CP023269.1\|AVJ23108.1\|3503259_3503871_+\|cysteine-dioxygenase	unknown	unknown	gnl\|CDD\|227840
CP023269.1\|AVJ23115.1\|3509745_3510438_-\|protein-TolQ	unknown	unknown	gnl\|CDD\|131843
CP023269.1\|AVJ23113.1\|3508525_3509287_-\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|367555
CP023269.1\|AVJ23104.1\|3499436_3500597_-\|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl\|CDD\|376451
CP023269.1\|AVJ23116.1\|3510485_3512351_-\|3-phytase	unknown	unknown	gnl\|CDD\|226698
CP023269.1\|AVJ23111.1\|3506518_3507859_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274819
CP023269.1\|AVJ23100.1\|3495737_3496352_-\|DNA-lesion-error-prone-repair-protein-ImuA	unknown	unknown	gnl\|CDD\|380271
CP023269.1\|AVJ23107.1\|3502140_3503046_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
CP023269.1\|AVJ23105.1\|3500717_3501503_+\|DeoR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
CP023269.1\|AVJ23103.1\|3498317_3499244_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223999

Protein	Function_ID	Function_description	E-value
CP023269.1\|AVJ23102.1\|3497564_3498152_-\|GDP-mannose-pyrophosphatase	gnl\|CDD\|184971	PRK15009, PRK15009, GDP-mannose pyrophosphatase NudK; Provisional.	8.68439e-74
CP023269.1\|AVJ23098.1\|3491085_3494157_-\|error-prone-DNA-polymerase	gnl\|CDD\|235553	PRK05672, dnaE2, error-prone DNA polymerase; Validated.	0
CP023269.1\|AVJ23101.1\|3496351_3496969_-\|repressor-LexA	gnl\|CDD\|171489	PRK12423, PRK12423, LexA repressor; Provisional.	1.35207e-130
CP023269.1\|AVJ23099.1\|3494314_3495730_-\|DNA-repair-nucleotidyltransferase	gnl\|CDD\|176458	cd03468, PolY_like, DNA Polymerase Y-family. Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.	1.63215e-67
CP023269.1\|AVJ23096.1\|3486755_3489275_-\|excinuclease-ABC-subunit-A	gnl\|CDD\|223256	COG0178, UvrA, Excinuclease ATPase subunit [DNA replication, recombination, and repair].	0
CP023269.1\|AVJ23114.1\|3509283_3509730_-\|protein-TolR	gnl\|CDD\|274306	TIGR02801, Protein_TolR, TolR protein. The model describes the inner membrane protein TolR, part of the TolR/TolQ complex that transduces energy from the proton-motive force, through TolA, to an outer membrane complex made up of TolB and Pal (peptidoglycan-associated lipoprotein). The complex is required to maintain outer membrane integrity, and defects may cause a defect in the import of some organic compounds in addition to the resulting morphologic. While several gene pairs homologous to talR and tolQ may be found in a single genome, but the scope of this model is set to favor finding only bone fide TolR, supported by operon structure as well as by score. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	1.01585e-47
CP023269.1\|AVJ23097.1\|3489271_3490984_-\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|237425	PRK13557, PRK13557, histidine kinase; Provisional.	2.92426e-118
CP023269.1\|AVJ23110.1\|3505533_3506508_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270276	cd13558, PBP2_SsuA_like_2, Putative substrate binding domain of sulfonate binding protein, the type 2 periplasmic binding protein fold. This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	8.21495e-95
CP023269.1\|AVJ23109.1\|3503867_3505451_+\|sulfurtransferase	gnl\|CDD\|238793	cd01535, 4RHOD_Repeat_4, Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative catalytic Cys residue.	6.81338e-71
CP023269.1\|AVJ23108.1\|3503259_3503871_+\|cysteine-dioxygenase	gnl\|CDD\|227840	COG5553, COG5553, Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only].	6.14458e-60
CP023269.1\|AVJ23115.1\|3509745_3510438_-\|protein-TolQ	gnl\|CDD\|131843	TIGR02796, Protein_TolQ, TolQ protein. TolQ is one of the essential components of the Tol-Pal system. Together with TolR, it harnesses protonmotive force to energize TolA, which spans the periplasm to reach the complex of TolB and Pal at the outer member. The tol-pal system proves to be important for maintaining outer membrane integrity. Gene pairs similar to the TolQ and TolR gene pair often number several per genome, but this model describes specificially TolQ per se, as found in tol-pal operons. A close homolog, excluded from this model, is ExbB of the ExbB/ExbD/TonB protein complex, which powers transport of siderophores and vitamin B12 across the bacterial outer membrane. The Tol-Pal system is exploited by colicin and filamentous phage DNA to enter the cell. It is also implicated in pathogenesis in several bacterial species [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	1.04516e-80
CP023269.1\|AVJ23113.1\|3508525_3509287_-\|energy-transducer-TonB	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	7.77742e-14
CP023269.1\|AVJ23104.1\|3499436_3500597_-\|alpha-hydroxy-acid-oxidizing-protein	gnl\|CDD\|376451	pfam01070, FMN_dh, FMN-dependent dehydrogenase.	4.3852e-175
CP023269.1\|AVJ23116.1\|3510485_3512351_-\|3-phytase	gnl\|CDD\|226698	COG4247, Phy, 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism].	2.89046e-93
CP023269.1\|AVJ23111.1\|3506518_3507859_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|274819	TIGR03860, FMN_nitrolo, FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family. This model represents a distinctive clade, in which all characterized members are FMN-binding, within the larger family of luciferase-like monooxygenases (LLM), among which there are both FMN- and F420-binding enzymes. A well-characterized member is nitrilotriacetate monooxygenase from Aminobacter aminovorans (Chelatobacter heintzii), where nitrilotriacetate is a chelating agent used in detergents. [Unknown function, Enzymes of unknown specificity].	0
CP023269.1\|AVJ23100.1\|3495737_3496352_-\|DNA-lesion-error-prone-repair-protein-ImuA	gnl\|CDD\|380271	NF033429, ImuA_translesion, translesion DNA synthesis-associated protein ImuA. A three-gene cassette encoding ImuA, ImuB, and ImuC (""inducible mutagenesis"") is induced by DNA damage, is capable of DNA synthesis across DNA damage lesions, and consequently is associated with mutagenesis. This family, ImuA (previously misnamed SulA in Pseudomonas putida) shows some homology to SulA itself and to RecA. ImuB resembles Y-family polymerases but may be catalytically inactive. ImuC is a C-family polymerase, and catalytically active.	6.17104e-80
CP023269.1\|AVJ23107.1\|3502140_3503046_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	4.95237e-45
CP023269.1\|AVJ23105.1\|3500717_3501503_+\|DeoR-family-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.10114e-74
CP023269.1\|AVJ23103.1\|3498317_3499244_+\|alpha/beta-hydrolase	gnl\|CDD\|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	1.18322e-19

>CP023269.1|AVJ23105.1|3500717_3501503_+|DeoR-family-transcriptional-regulator
MHNTHQAIDLPSLRKQKILLLLERDGKVTASELVEHFAVSQDTIRRDLGELAAAGLLQRVHGGALPRPKDTGKDFFTRVGETNEVKRHLARVAAGRVKDGQIVLFDSGSTTLQIAQCLPHALHLTVVTPSPMIAIALADHPHIKVILAGGQLNPATLSTGGHEAVRLIQSVKADLLFTGVCALHPQVGITSLHFGEVAVKQALLDSASHVIAVTTSDKLGAVEPFVVAPCSRIHTLITEWDAPDVHAYEQLGLQVQRVDVQ
>CP023269.1|AVJ23104.1|3499436_3500597_-|alpha-hydroxy-acid-oxidizing-protein
MPLITTIEDLRKLAQKRVPRMFYDYADSGSWTESTYRANETDFARIKFRQRVARNIDERSIRASMIGQDMAMPVALAPTGLAGMQHADGEILTARAAAAFGLRYTLSTMSICSLEDIAEHVGQPFWFQLYVMRDRSFIEQLIERAKAAGVDALVLTLDLQILGQRHKDLINGLSAPPKLTLPNILNMMTKPRWVMGMLGTQRRGFGNIVGHVKGVADMSSLSSWTAQQFDPRLSWDDVAWIKRCWGGKLIIKGILDVEDARLAADCGADALVVSNHGGRQLDGAPSSISQLPAIVEAVGNRIEVWLDGGIRSGQDVLKAMALGAKGTMIGRPHLYGLGAMGEAGVTKALDIIARELDVSMALCGYKDIREVNREILLPGTFPGSTA
>CP023269.1|AVJ23103.1|3498317_3499244_+|alpha/beta-hydrolase
MSSVSMPRRGLRWLVWLCMAVLIVGLPVGCAVLQHKERELVFRIEPGTAGWYTGLPKAVQEFELKPASFKAGQNIHGWWYPAANKDAPAILYLHGVRWNLTGQLFRIEQLHALGFSVLAIDYRGFGQSQGDLPSEATVYEDARIAWERFQTLQPDPGKRLIYGHSLGGAVAIDLAAELGKQVPLPVRGLVIESTFTSLADVATAVANTSLPVRWLLSQKFDSIDKIADIHMPLLVVHGLDDRYVPPRFSQQLFEAAQQPKHLLLVPGASHNNSMNLAGRSYGQALENLMRTKMPAQIVTHSIGRDNAS
>CP023269.1|AVJ23102.1|3497564_3498152_-|GDP-mannose-pyrophosphatase
MNNSPVRITAEETLSDNWYLLKKYSFDLRRRDGSWQAQTREVYDRGNGATILLYNREQRTVLLIRQFRMPTFVNDYPGYLIEAAAGLLDNASAEERIRLEAEEETGYRVGHVEKIYAAFMSPGSVTERIHFFIGEYQPGDRVGAGGGLEEEGEDIEVLELGFEQALAMVQSGEIVDGKTIMLLQHLELRMLKEGW
>CP023269.1|AVJ23101.1|3496351_3496969_-|repressor-LexA
MYSMTNLTPRRTAILTFIRERIAQQGQPPSLAEIAEAFGFASRSVARKHVVALTEAGFIEVNPNQARGIRLLNQPARPEWLDVPVLGRVAAGRPIGADAEVHSRLQLDPATFAKTPDYLLRVQGDSMIEDGILDGDLVGVRRSAEALNGQIVVARLDGDVTIKRFERNGDRVRLLPRNPAYQPIVVGPEQDLAIEGVFCGLVRQG
>CP023269.1|AVJ23100.1|3495737_3496352_-|DNA-lesion-error-prone-repair-protein-ImuA
MGAVVALDSLFNGGRVWKGRPAAPPASVHPTGLAALDAVLPSGGWPESALSEILMAQDGVGELQLVLPTLARLSALGERIVLVAPPYTPYPHAWQNAGVDVRQLSIIRAEERDALWAVEQCLRSGSCGAVLCWPRKADDRALRRLQVAAETGQTLAFAWRSLSEAINASPAALRLAVEARPAQVRVLKCRGGLAHPAPIALAGH
>CP023269.1|AVJ23099.1|3494314_3495730_-|DNA-repair-nucleotidyltransferase
MRWVCIVFPQLALDGAQRVHPEPEQPLALLAGTPQRRVLQTVNAAARALGLRPGQSLTAAHALVKQFACVEYDPLEIERLQQFLATWAYRFSSQVSLYYPRALLFEIESSLGLFGPWPHLEARLRKELTELGFRHRIVAAPNPAAARILANGYDGLAVADDSALMQALASLPVDRAGLEPQAATALSRMGLRSLAQVQALPRHTLARRFDASLLKHLDALNGQRPLALDFYQPPDQFDARIELNFDVQSHQALLFPLRRLTGDLSAFLCGRDSGVQRFDLHLEHAQAQDSVIKVGLLSAEREPSMLFELARGRLEQVQVTAPVRGVRLVAEDLPVFVPQRQDLFDDRPQQTLPWEQLRERLRARLGDEAVQGLRFQADHRPECAWQAATDHQACPSLNKVRRPGWLLPQPTLLAEHGVQILMGPERIESGWWDGADVRRDYYLVQTRAGQQGWAYRTVGQGDGLWLQGWFA
>CP023269.1|AVJ23098.1|3491085_3494157_-|error-prone-DNA-polymerase
MNYAELHCLSNFSFQRGASSALELFERAKCQGYSALAITDECTLSGIVRAWQAAKAVDLPLIIGSEMHIENGPKLVLLVENLSGYQHLCRLITLARRRAEKGNYRLLQEDFEQPLPGLLALWVAQDSDTQASLDWLRRTFDQRLWLAVHLHCGQDDARHLQQRLQLAHSLQIPAVACGDVHMHARGRRALQDTMTAIRHHVPVAEAGTRLHPNGERHLRNLDALAALYPQALLDETLAIARRCTFDLGQLRYHYPRELVPAGHDAQSWLRTLTEEGIAQRWPEGIDDKTLQQIHRELQLISELGYESYFLTVHDIVRFARSRSILCQGRGSAANSAVCFALGITEINPSLTNLLFERFLSKERNEPPDIDVDFEHERREEVLQYVFQRYGRTRAALTAVVSSYHATGAVRDVAKALGLPADQINALADCCGRWSDEAPPLERLRESGFDPDSPLLRRVLTLTQQLIGFPRHLSQHPGGFVISEYPLDTLVPVENAAMAERTIIQWDKDDLDAVGLLKVDILALGMLSAIRRCFDLLRRHRHRDLSLATIPKEDPATYAMISKADTIGVFQIESRAQMSMLPRLKPQTFYDLVIEVAIVRPGPIQGGMVHPYLRRRNNEEPTTYPSPQLKAVLERTLGIPLFQEQVMQIAMVAADYSPGEADQLRRSMAAWKRHGGLEPHQQRLRTGMLKNGYTEAFAAQIFEQIKGFGSYGFPESHAASFALLTYASCWLKCHEPAAFACALINSWPMGFYSPDQILQDARRHRLQIRPVDVQASDWECSLEPIDGQQPAIRLGLRMISGFREDDGRRIEAARQQRLFNDIADLDARAGLDTRAQALLADAGALRALAGNRHQARWDVAGVHQQLGLFAGLPSPDETRVALPEPTVGEDLHADYATLGTTLGPHPLALLRAELRRRRCRSSQELLTVEHGRNVSIAGLVTGRQRPGTASGVTFVTLEDEFGNLNVVVWRDLAERQRQALVGSRLLKVDGRWEAVGEVRHLIAGRLTDLTPLLDGMVVRSRDFH
>CP023269.1|AVJ23097.1|3489271_3490984_-|hybrid-sensor-histidine-kinase/response-regulator
MQFLSNPHGCEGWAGEMAQRIRTFDWSSTDLGPLDQWSTSLACTVQMMLASPVPMVMLWGRAGYMIYNDSYSVFAGGRHPYLLGTPVELGWPEVAEFNRHVVDTCLAGGTLSFNNKELVLSRHGQPESVWLDLYYSPVAGDNQQPAGVLAIVVETTELVKSERVRQELTHNLEQRVAAEVQARSAAEDQLRQSQKLEAIGGLTGGVAHDFNNLLQVIAGNLHLLARHEPDNCQVQRRVTAAIAAVERGAKLSSQLLAFARRQPLSPAVYNPQRIYAGLGELLQRALGETIHIDVQLPQDSWCINVDRNQLENALLNLAINARDAMQGEGVIRITGENVILNPDDCIGKSIKPGEYVRLAVADTGVGMSEATLKRAFEPFFTTKREGHGTGLGLSMVFGFVRQSGGHVDMWSEEGKGSVVQMYFPHCLEPECFDDYSDADLQGGGQETILVVEDNEGVRLTVVELLQQSGYTVLTAEDGDRAMQVLQRGVSPDLIFTDVVMPGRVKSTDLATWARAQNPPVPVLFTSGHTRDILSSNHLLSADIHLLSKPYSPDALTQRVRRVLSARQGCP
>CP023269.1|AVJ23096.1|3486755_3489275_-|excinuclease-ABC-subunit-A
MTSQRNIPPLTARQTGFVRVRGAREHNLRNVDVDIPRDALVVFTGVSGSGKSSLAFSTVYAEAQRRYFESVAPYARRLIDQVGVPDVDSIEGLPPAVALQQQRGTPSARSSVGSVTTLSSLIRMLYSRAGRYPKGQAMLYAEDFSPNLPQGACPQCHGLGRVYEVTEALMVPDPSLTIRQRAVASWPLAWQGQNLRDILVTLGYDVDIPWRELPKKQRDWILFTEETPTVPVYAGFTPQQTREALKRKLEPSYQGTFSGARRYILHTFAHTQSALMKKRVSQFMQGSACPLCEGKRLNQAALSVKFAGVDIGELSQLSLAQLAELLQPVAAGQDTMKLSVEKRLAAQRIAQDLLERVNTLIELGLGYLSLERSTPTLSSGELQRLRLATQLGSQLFGVIYVLDEPSAGLHPADGEALFTALDRLKAAGNSLFVVEHDLETMRRADWLIDVGPAAGEHGGQVLYSGPPAGLADVEASQTREYLFASPRPANVPSREPAGWLKLKGVTRNNLKDLNVDFPLGRFTAVTGISGSGKSSLVSQALLELVGTALGRVLESDDEPSLEDAAPQASGGRISAGLEHIQRLVQVDQKPIGRTPRSNLATYTGLFDNVRKLFAATPAAKKRNYDAGQFSFNVAKGRCPNCEGEGFVSVELLFMPSVYAPCPTCHGARYNPDTLAIKWQGLNIAQVLGLTVEQAVQVFAEQPGILRSLVVLRDIGLGYLRLGQPATELSGGEAQRIKLATELQRNARGATLYVLDEPTTGLHPRDVDRLLSQLNQLVDAGHTVVVVEHEMRVVAQSDWVIDIGPGAGDLGGRVVACGAPQKVAKSKTSRTAPFLARELV
>CP023269.1|AVJ23107.1|3502140_3503046_-|LysR-family-transcriptional-regulator
MKIDDIDAFVEVIRCQSISHAAASLQLTQPAITRRVQNFEQALGVELFDRNTKPLKPTLIGTRVYEQCRLILREMDALRELVATDAPPTGVLRLGVPQTIGDVVLLDALKHLRSEYADLRAQVATGWGSQLVGKIERGELDAAVALFPAGKIFPDNLVGESIGKMELVVVCAKAQLPKKPCKLADVYQSGWILNPDGCGFRAGLQRTLSDQGLALRVNLETFGTELQLGLVADGLGLGLVPRPLLERSAHREHLAAMPLKDFKPVMDLWLIYPHFLGNLQGPVDAFGQWVADALHKIRSAA
>CP023269.1|AVJ23108.1|3503259_3503871_+|cysteine-dioxygenase
MTQARHPERLRAFIGALAELIDGNPREGDLLHRGGKLLAQLVSHDDWLPDDFAQPDPERYQQFLLHADSRQRFSVVSFVWGPGQRTPIHDHRVWGLIGMLRGAEVSQGFARAPGGSLIARGEPVQLVPGQVEAVSPKVGDIHQVSNAHGDQVSISIHVYGANIGAVRRAVYQPDGSEKLFISGYSNAYLPNIWDLSKEKSPAL
>CP023269.1|AVJ23109.1|3503867_3505451_+|sulfurtransferase
MTTLSTRSFAQIRQALLAREEVALIDVREEAPFAEAHPLFAANIPLSKLELEVYARIPRRDTQVTLYDNGEGLAHRAAERLVALGYTQVSLLEDGLDGWRRAGGELFIDVNVPSKAFGELVENQRHTPSLAAEEVQALLDSQADVVVLDARRFDEYQTMSIPTGISVPGAELVLRARELAPDPATRIIVNCAGRTRSIIGTQSLINAGLPNPVAALRNGTIGWTLAGQTLAHGQARRFAPTSENHRQLAAQEARGVADKAGVKRATLNDLQRWQQDATRTTYLFDVRTVEEFEAGHLPGARATPGGQLVQETDHVASVRGAHLVLVDDDGVRANMSASWLAQLGWQVSVLDDLQATHFSERGAWVAPAPPPPQAELISPHTLADWLSHGDTQVLDFTASANYVKRHIPGAWWVLRAQLPEALSKVPSAQRYVLTCGSSQLARLAVPEVEALTGKPVFLLQDGTAGWVHAQLPLESGESHLASPRIDRYRRPYEGTDNPREAMQAYLDWEFGLVEQLARDGTHGFYVI
>CP023269.1|AVJ23110.1|3505533_3506508_+|ABC-transporter-substrate-binding-protein
MLYALPFKRLLWGAALAFGLLSTVQAGDLQPLRVANQKSTIKALLEASGESQNVPYEIKWSEFPSASPLGEALNAGAVDVGALGDAPYVFALGAGASIKVISIIHAEGRNTTALLVPKDSPIKTAADLKGKKIVTGRGSIGHYLAIKALNDAGLTTQDVQFIFLLPAESRLVLDNGTADAWATWDPYTTVVTSQSNARVLVSGKQLLSNHLYFAATGQAIADKRVQLDDFVARIDRAYAWANTHPEQYAAAQAKITGLPLAVHIEVAQDTHLSPVTIDDTVIHGLQATADTYVKEGLLSKHIDVSQGFDSSFNAKRIPLEQASR
>CP023269.1|AVJ23111.1|3506518_3507859_+|LLM-class-flavin-dependent-oxidoreductase
MSKPRQLKLGAMVHGVGHGWGEWRHPQAQPDASTNFGFYKQQTELAEAARFDFVFIADSLHIHPKSSPHYLNRFEPLTILSALAALTTHIGLVATVTVSYTEPYQVARQFASLDHISGGRAGWNVVTSWLSGTADNFGKAEHPPHAVRYRIAKEHLNVVKGLWDSWEDDAFAYNKHSGEFFTPGKLHALNHKGEFFSVKGPLNIARSRQDQPVIFQAGTSEDGRNFAAENADAIFVHVETIDEAKAYSADLKRRAKGFGRDPDSLSILPGIRPIVGSDAAEVESRYQQAVALVTVEDAIVALGRPFNDHDFSQYPLDAPFPELGDLGANSQKGGSERIKQLARDEGLTLREVALRFSRPQRDFVGTPEQVADAIQTWFESGASDGFIINSVLPDGLQYFTEWVVPVLQQRGLFRTEYSGHTLRDNLGLEVPANRYSLVETHEKALA
>CP023269.1|AVJ23112.1|3508177_3508498_-|hypothetical-protein
MGAGLPAIAVAQLNIQWLTHHLRGQARSHRDLCQALIFCGQCMTSVGAGLPAKAVAQLNIQLLTHHLREQARSHRDLCQALIFCGQCMTSVGAGLPAKAVAQLNIQ
>CP023269.1|AVJ23113.1|3508525_3509287_-|energy-transducer-TonB
MTAMIMHSPALALAPNGDGLWRKSLAASLAVALHGAVAVALMLGWSTERPGVDAPRVMHTQLVVLPAPAPAPVPTPEPVAAALAEPVVIPVPTRPTVDPQVQAQKLEKAALARKRVEEKKLEQQQQRMATEQRNRELEQQRLSQARAASEKARAAVPAPTPAFDSRQYQPLSKAAPDYPERALDKNIEGDCSVEYTVNTQGHVENPKVLDGCHPLFIRPSLAAANTFRYQPRIVDGKAVAVPAVRNTFHYRIK
>CP023269.1|AVJ23114.1|3509283_3509730_-|protein-TolR
MLIRPQRKHGPKAEMNVVPYIDVMLVLLVIFMVTAPMLTQGVKIELPKVAAEALATDTRQQILTLSVKADGGYYWNLGGELDTRQQTDSAVTLEEMSAKVMQVVAARSDTQVYIRADDNAGYGRVVAAMAVLQKGGVSNLGLVTEAPQ
>CP023269.1|AVJ23115.1|3509745_3510438_-|protein-TolQ
MHATMEHMTIWSLISDASLLVKAVMVTLLLASLLSWYLIIQRSSVLRGLERQLNGFLARFRVASDLQPLYRDTVQAGEGGVAPIFIAGMQEYQHLHHHDPAVLEGVERALQVAITEQELELEKGLQFLATVGSVSPYIGLFGTVWGIMNSFLGLSQVQQATLSTVAPGIAEALIATAIGLFAAIPAVIAYNRFAARSQTLLTRYYAFGNELQVHLHRMLRGTSINLAVAA
>CP023269.1|AVJ23116.1|3510485_3512351_-|3-phytase
MRISKLCLLVALVTSGKAFATDLPLTPWAPSLNAQAVAFLPGGTQRVAASARDGLLLLDDKGVELARFKGRFSSLDTRAAGTQSLIASLDNDRQQALLIGLDGAGKTWGTPLYLPTRDFAVNSLCLYRDSAANLFVFLVGEEGKGEQWLVGNGSTLLAQAQRVRSLPLPPSAQYCQVDDAAERLVVNEQNVGWWAYPAHPEAEVKRTPVALFDDPQREAGAMALVPGGMLALDPKTAQLQLFQQVGERWVGQSSLALPGLKEPEQLVIQGRQVLVRDDDSGQLYQGRLDWQATPVPVAPILAQVAALRQTEPVGRQGDAADDPAIWVHPETPAKSRVLGTNKKQGLLAYDLDGKLLQELAVGRLNNVDIRPGFKLGTHTVDLAVASNRDRNSLSLFSIDRQSGELLEAGEVPTPLKDIYGICLYQPASGELYAFANDKDGTFLQYRLSAPAGRVQGEVVRQFKVDSQPEGCVADDQRQRLFIGEEDVGVWAMDARADQPATLTPVIKVGPQLHADVEGLALYQSPARDYLVISSQGNDSYLVLDAEPPFAVRGALRVGLNAAAGIDGASETDGLEVTAVNLGGPWSQGMLVVQDGRKRMPEQAQNFKFVPWAEVSRALKLP

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Crispr_ID: CP023269_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023269_8

3797577-3797687

Orphan

Consensus_repeat	Method
TCAGGTAGATAGTCGTCGGCTGTCAGGCCGCCATCGCA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of CP023269_8

>merge|CP023269|8|3797577-3797687|CRISPRCasFinder
TCAGGTAGATAGTCGTCGGCTGTCAGGCCGCCATCGCAAGCAAGCCAGCTCCCACAGTTGGATCGTTAGGGTGTCAGGTAGATAGTCGTCGGCTGTCAGGCCGCCGTCGCA

>CP023269|8|8|3797577-3797687|CRISPRCasFinder
TCAGGTAGATAGTCGTCGGCTGTCAGGCCGCCATCGCA	AGCAAGCCAGCTCCCACAGTTGGATCGTTAGGGTG
TCAGGTAGATAGTCGTCGGCTGTCAGGCCGCCGTCGCA

Protein	Signature genes	Signature genes Name	Protein_function
CP023269.1\|AVJ23349.1\|3806805_3807852_+\|ornithine-cyclodeaminase	unknown	unknown	gnl\|CDD\|236064
CP023269.1\|AVJ23337.1\|3794490_3795735_-\|pyridine-nucleotide-disulfide-oxidoreductase	unknown	unknown	gnl\|CDD\|223523
CP023269.1\|AVJ23336.1\|3793683_3794490_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
CP023269.1\|AVJ23330.1\|3782489_3783017_+\|TRAP-transporter-small-permease	unknown	unknown	gnl\|CDD\|225632
CP023269.1\|AVJ23332.1\|3784440_3785316_+\|aldose-epimerase	unknown	unknown	gnl\|CDD\|185698
CP023269.1\|AVJ23331.1\|3783018_3784299_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224509
CP023269.1\|AVJ23333.1\|3785296_3786442_-\|HlyD-family-secretion-protein	unknown	unknown	gnl\|CDD\|224482
CP023269.1\|AVJ23341.1\|3797761_3798250_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
CP023269.1\|AVJ23345.1\|3802011_3803391_+\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|235660
CP023269.1\|AVJ23338.1\|3795786_3796122_-\|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
CP023269.1\|AVJ23335.1\|3788272_3793546_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214614
CP023269.1\|AVJ23334.1\|3786438_3788082_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
CP023269.1\|AVJ23343.1\|3799682_3800741_+\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
CP023269.1\|AVJ23350.1\|3808079_3808859_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270421
CP023269.1\|AVJ23347.1\|3804750_3805644_-\|GNAT-family-acetyltransferase	unknown	unknown	gnl\|CDD\|235142
CP023269.1\|AVJ23348.1\|3805867_3806794_+\|amidinotransferase	unknown	unknown	gnl\|CDD\|227211
CP023269.1\|AVJ23342.1\|3798445_3799681_+\|3-methyl-2-oxobutanoate-dehydrogenase-(2-methylpropanoyl-transferring)-subunit-alpha	unknown	unknown	gnl\|CDD\|223997
CP023269.1\|AVJ23339.1\|3796216_3797080_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293810
CP023269.1\|AVJ23344.1\|3800741_3802007_+\|branched-chain-alpha-keto-acid-dehydrogenase-subunit-E2	unknown	unknown	gnl\|CDD\|237001
CP023269.1\|AVJ23346.1\|3803594_3804614_+\|branched-chain-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|237363

Protein	Function_ID	Function_description	E-value
CP023269.1\|AVJ23349.1\|3806805_3807852_+\|ornithine-cyclodeaminase	gnl\|CDD\|236064	PRK07589, PRK07589, ornithine cyclodeaminase; Validated.	0
CP023269.1\|AVJ23337.1\|3794490_3795735_-\|pyridine-nucleotide-disulfide-oxidoreductase	gnl\|CDD\|223523	COG0446, HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only].	5.95945e-29
CP023269.1\|AVJ23336.1\|3793683_3794490_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	6.55425e-22
CP023269.1\|AVJ23330.1\|3782489_3783017_+\|TRAP-transporter-small-permease	gnl\|CDD\|225632	COG3090, DctM, TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism].	6.87835e-26
CP023269.1\|AVJ23332.1\|3784440_3785316_+\|aldose-epimerase	gnl\|CDD\|185698	cd09021, Aldose_epim_Ec_YphB, aldose 1-epimerase, similar to Escherichia coli YphB. Proteins similar to Escherichia coli YphB are uncharacterized members of the aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	2.6048e-108
CP023269.1\|AVJ23331.1\|3783018_3784299_+\|hypothetical-protein	gnl\|CDD\|224509	COG1593, DctQ, TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism].	1.91928e-137
CP023269.1\|AVJ23333.1\|3785296_3786442_-\|HlyD-family-secretion-protein	gnl\|CDD\|224482	COG1566, EmrA, Multidrug resistance efflux pump [Defense mechanisms].	5.33618e-95
CP023269.1\|AVJ23341.1\|3797761_3798250_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	8.46314e-47
CP023269.1\|AVJ23345.1\|3802011_3803391_+\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|235660	PRK05976, PRK05976, dihydrolipoamide dehydrogenase; Validated.	0
CP023269.1\|AVJ23338.1\|3795786_3796122_-\|ArsR-family-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	7.58251e-17
CP023269.1\|AVJ23335.1\|3788272_3793546_-\|hypothetical-protein	gnl\|CDD\|214614	smart00317, SET, SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain. Putative methyl transferase, based on outlier plant homologues.	1.83488e-11
CP023269.1\|AVJ23334.1\|3786438_3788082_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	6.33758e-20
CP023269.1\|AVJ23343.1\|3799682_3800741_+\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	0
CP023269.1\|AVJ23350.1\|3808079_3808859_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270421	cd13703, PBP2_HisJ_LAO, Substrate binding domain of ABC-type histidine- and lysine/arginine/ornithine transporters; the type 2 periplasmic-binding protein fold. This subgroup includes the periplasmic-binding proteins, HisJ and LAO, that serve as initial receptors in the ABC transport of histidine and lysine-arginine-ornithine amino acids. They are belong to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	6.15557e-125
CP023269.1\|AVJ23347.1\|3804750_3805644_-\|GNAT-family-acetyltransferase	gnl\|CDD\|235142	PRK03624, PRK03624, putative acetyltransferase; Provisional.	2.91855e-59
CP023269.1\|AVJ23348.1\|3805867_3806794_+\|amidinotransferase	gnl\|CDD\|227211	COG4874, COG4874, Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown].	7.99233e-106
CP023269.1\|AVJ23342.1\|3798445_3799681_+\|3-methyl-2-oxobutanoate-dehydrogenase-(2-methylpropanoyl-transferring)-subunit-alpha	gnl\|CDD\|223997	COG1071, AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion].	9.68481e-141
CP023269.1\|AVJ23339.1\|3796216_3797080_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293810	cd07724, POD-like_MBL-fold, ETHE1 (PDO type I), persulfide dioxygenase A (PDOA, PDO type II) and related proteins; MBL-fold metallo-hydrolase domain. Persulfide dioxygenase (PDO, also known as sulfur dioxygenase, SDO, EC 1.13.11.18) is a non-heme iron-dependent oxygenase which catalyzes the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria. Mutations in ethe1 (the human PDO gene) are responsible for a rare autosomal recessive metabolic disorder called ethylmalonic encephalopathy. Arabidopsis thaliana ETHE1 is essential for embryo and endosperm development. Bacterial ETHE1-type PDOs are also called Type 1 PDOs. Type II PDOs (also called PDOAs), are mainly proteobacterial. These enzymes belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	1.31543e-66
CP023269.1\|AVJ23344.1\|3800741_3802007_+\|branched-chain-alpha-keto-acid-dehydrogenase-subunit-E2	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	3.02868e-177
CP023269.1\|AVJ23346.1\|3803594_3804614_+\|branched-chain-amino-acid-aminotransferase	gnl\|CDD\|237363	PRK13357, PRK13357, branched-chain amino acid aminotransferase; Provisional.	0

>CP023269.1|AVJ23339.1|3796216_3797080_+|MBL-fold-metallo-hydrolase
MPALIQAFLDDASSTYTYIVYEADGGPCAIVDSVLNYDPASGRTDTAQADKVIAFVREHGLHVQWLLETHAHADHLSAAPYLRRTLGGKIAIGESISKVQGVFKNLFNLEPEFRVDGSQFDHLFAPDEIFHIGNLKAQALHVPGHTPADMAYLIDGRLILVGDTLFMPDVGTARCDFPGGDARQLYASMRKLLAFPSDTKLYVCHDYPPEGREAKCQTTVAEQRAGNIHVHDGVDEAAFVQMRTQRDAGLGMPTLLLPAIQVNVRAGNMPPAEENGVTYLKIPLNQL
>CP023269.1|AVJ23338.1|3795786_3796122_-|ArsR-family-transcriptional-regulator
MESTLSEGEVAQLRASASKACALLKALANEDRLLILCQLTQGERNVGELEALTGVRQPTLSQQLGILRDEGLVATRREGKYIFYGLASHEVIQVMKTLSGLYCGAVIKSWA
>CP023269.1|AVJ23337.1|3794490_3795735_-|pyridine-nucleotide-disulfide-oxidoreductase
MTEQHWGPTISGDIVVIGGGSAGIGLLASLLKRDPHLNITLIEPNDYHCYQPAWTLVGGGAYDLHKTRRPLADVLPNGVSWVQAAVSELLPDENTLVLDSGQRVTWKNLIVCPGLRLAWEKIEGLQDTLGQHGVTSNYSYEHAAYTWQLVQQLKGGKALFTQPAMPIKCAGAPQKALYLSCDHWLKQGDLKHIDVEFNLAGAALFGVPTFVPPLMKYVEKYNARLAFNSNLVKVDGPARKAWFEVKDAEGNATVEEKTFDMLHVVPPQLSPDFIRQSPLADAAGWCEVNPHSLQHLRYPHIFGLGDVCGTTNAKTAAAVRKQIVVVAENLLALRKQAPLPLKYDGYGSCPLTVEKGKVVLAEFGYGGTLLPTFPLDPTQARRSMWFLKATLLPWFYWNGMLKGREWLTRLSKVD
>CP023269.1|AVJ23336.1|3793683_3794490_-|sulfite-exporter-TauE/SafE-family-protein
MLLASLLGVLMGLVMGLTGAGGGILGVPALVLGLGLTMTQAAPVSLLAVGAAAAVGAIDGLRHGLVRYRAALLIALLGALFSPLGVFVAHQLSEPVLMGLFSALMVLVAWRMLQREKREAGPSDHGAASWGQKNCMLNQQTGRLAWTAKCSATLAALGAVTGAVSGLLGVGGGFLIVPAFKQLTDVQMRGIVATSLMVVSLLSLIGVAGAFHAGVSIEPVGWVFIGASVVGMLAGRRLCSVIPARVLQVGFASLCGVVAIGMLASALL
>CP023269.1|AVJ23335.1|3788272_3793546_-|hypothetical-protein
MTITAAHTHFSLPLAAAEKRPPLVADDLEPSLTPQRPSQNLPLPNSPVFSLGHLGGALSWPNPLSADAQRRLRLATMNYAHPLGDQPLVMQTKGGVLEFLRYRQPLPAEVGSDPAKILEALVNSPQGQRMGNALQQTMQGIDSESSASDYLLAAIALQMDPESITAPDCNSVAGFDLGGDTHGGHHASTVVAGLAEHLSRTGKTSAALASVGAYLLLAKSAPQFLIKDIPATVKVGSQAWASLAIAAMTIEAQTPGKVPGMTFAQVMSEAQEARRVDPGVTQAAETVALLDWAVASGVLTKRQNGDYPPAQLESARAAFNAQLDTRLTASHALDKALPTRKEIALTKLKERFGDLGAFFEEKVFAVDQHYVKIEGGGISLLDVAMDDWLESRPFKAHEPSSSLKGNDLQRVLTGLNANRQFGVPAEFERQFSRAMEEKKAAVNTTVRHMISQLPLQDRKHFEFGNVSFFQKGSYVMDGHFNNTYAQNEPGLLVKTELQGTSHAYVIDFNKGTIEKTSLYNTKVKEDRDGNKVSTTKLFTPSHKADDLGRGRPLNNAPWDSFTSARSHGVATAFVEHLDLDDPAIKQQARGQTALDKANAQLSEFLLNLIPFRSAIVNFQNGQYGAGAFDLLLDVFGFLTAGTATAGKLLKVGRSALSAGAKALRAVKVIGVATIDVLNPVGGVGDLPRLVGSAGLYVLSKGLKAVNKLRGATGSYDVLKAISKQYEAAATGTVKVAGQTVEGAAVLKGGKWYAFDADAMRPYGGPLDEFKAATHAVDGEVDTASFDGPSELSHELFGHFKVPESKIAGLTRNSQGVYVAADGHSSHIRHTDSNGDTAVYEVRQVSRTEEGVVQARVYHNNRQTELLVQHVQGDEWQRLGAPGGGQITAELLKAWEALSPQEQIRLTRKGFAKQNKLTQKTFEFFVKPDGQLTDSGVLVRDRPANAFTAKVTETHVREWKNMTQAQRDEMTQEGFAVLHNLRPGTFKTYARKDGTLMTRGETLINSSVPTKSNQITDDHLRQWDELFRQPGNSLTSAQFVSQHGLSQRSWAQYVNADGSLKGAGAQRLERALQSAARASAVQAQTPMADHLRAWQALSLEQQQSLTPAGFARQQHLHPKVFNRYVKPDGQLTAIGVAVRDRAPNTPFYTVTETHIRDWQDMPQTERDEMTLEGFAELYHVNPGSFKTHVRRDGTLGPVGRELMDRVVGIAPNKITDDHLRQWKAYFEDPNNAITQAQFTSENGLHPGTWRDWVNADGSLKTTASERLERAALGPITHVPRARMELITAGHLREWEALPPAQQQSLTRRGFARQKHLSPRTFEYYVQPDGKLSPAGVTVRDRSANMVAGRVTETHIDRWQKLTQQARETMTMEGFAVQHNLSVHSFRAYVRPDGGLSAAGEALMKNVTDGGYRRITGDLLRQWQALAESADNSVTQAQFVQQHRLSPDLWSKYVRADGSFTAIASQRFRRLQQGTGPRPVPEQSITESPRKRPASEPLDPPPSKVGAGTTQGLEAPAPAATVPPVVIKVEPSDFPTLPRHQIDNTLPILQDPVNPRISLTQSLEGPIDDIRISHWNGVLDGLDSPTKARVSAQIKASIKDWLRTEGQHQTRFDDALEVVTPLDDGGPARGASVWARRDIPQFEVLGPYAGKYHADEASLFEEQRKQGSRAVMTYLFGTRSGTRTVSGLHTGNTLSLINTSQLGEGPAWMSNNVVSIAVGKNLTFYVALKDIKRGEELLLDYGPFYKPVPDIAIKPDPDR
>CP023269.1|AVJ23334.1|3786438_3788082_-|MFS-transporter
MDKYTPHTWQPHERPSLPGSPSTPLHPTRKRWLFALVGVLVAITGGLGNALVIANLQYLQGALGATTAEMAWLPAAYVMTNVCMNLLLVKFRQQFGLRAFTEVFLVLYALVTFGHLFVNDLSSAIAVRAAHGMVGAALSSLGLYYMIQAFPAKWRLKALVLGLGTAQLALPLARLFSEDLLQIAEWRGLYLFELGLALICLGCVFLLKLPPGDRFKTFEKLDFLTFAILSSGVALLCAVLSLGRIDWWLEAPWIGVASACSLVLIMAGLAIEHNRSNPMLMTRWLGSGVMIRLALAVVLIRMVLSEQSTGAVGFMQMLNMSYQQMHTLYVVMLAGAIAGLVVSALTINPAHLLMPLIISLALMATGSVMDSFSSNLTRPQNLYISQFLLGFGGTFFLGPTMVLGTKNVLTNPRNLVSFSVMFGICQNLGGLIGAALLGTFQIVREKYHSSMIVEHLTLIDPLVAARVQSGGAAYGKIVADPELRNLMGIRSLATAATREANVMAYNDVFMLIAIIAILTMLWIFARSLWLMSTTKAIPPVQPSGATS
>CP023269.1|AVJ23333.1|3785296_3786442_-|HlyD-family-secretion-protein
MTEPSTTTTTAIAATPEGSTPPGAVPTQLRPLRVRIISSLGFAAIAIIGVLIVLYAWQLPPFSSAVETTENALVRGQVTIIGPQLSGYVFEVPVQDFQYVKTGDLLVRLDDRIYKQRLDQALAQLAVQKASLANVVQQRNSAEATIKLRQAALVDSQAQARKSTADLRRNEELISDGSVSKRELDVTRAANAQTIAAVAQAQASLEIARQDLQTVIVNRGSLEAAVASAEAAVELARIDLSNTRITAPRDGQLGQIGVRLGAYVNSGAQLMALVPKQLWVIANMKETQMDNVQVGQPVTFTVDALNHRKFHGTVQHISPATGSEFSLLQADNATGNFVKIAQRVPVRIIVDPDQAESERLRPGLSVVVSIDTAGRLKNSPP
>CP023269.1|AVJ23332.1|3784440_3785316_+|aldose-epimerase
MIELTDQFTHLVLAPALGASLVNWTVRATGQPLLRHSDGHAINTGLPGKLGCYPLAPWSNRIAHGGFDNPGGWLALAPNSLTDPFPIHGSAWQQAWEVTSQSEHEVALELRCETPFAYHARQRFRLNNGELNIQLCVTHLAKQPAWHGLGLHPYLPRRPGTRLQAKARQVWMSDAAKLPTALAPVPETWDFRQLKGLPEGLVDNAFCGWDGHCLIEQPELGYRLECQASGADYFLLYCPPGLEFFCIEPVSHPVNAHHLAGKPGLKLLEQGQSTHLNLNLKYMPNVRAVNS
>CP023269.1|AVJ23331.1|3783018_3784299_+|hypothetical-protein
MDALILLGSFVALILIGMPVAYALGLSALIGAWWIDIPFQALMIQIAGGVNKFSLMAIPFFVLAGAIMAEGGMSRRLVAFAGVLVGFVRGGLSLVNIMASTFFGAISGSSVADTASVGSVLIPEMERRGYPREFATAVTVSGSVQALLTPPSHNSVLYSLAAGGTVSIASLFMAGVVPGLLMSACLMVLCLIFAKKRDYPKGEVIPLKQALKIAADALWGLMAMVIILGGILSGIFTATESAAIAVLWAFFVTMFIYRDYKWRELPKLMHRTVRTISIVMILIAFAASFGYIMTLMQIPAKITTLFLTLSDNRYVILMCINVMLLLLGTVMDMAPLILILTPILMPVILGIGVDPVHFGMIMLVNLGIGLITPPVGAVLFVGAAVGKTSIEKTVKALLPFYAVLFLVLIAVTYVPALSLWLPHLVL
>CP023269.1|AVJ23330.1|3782489_3783017_+|TRAP-transporter-small-permease
MKTLLLRFNDRLYMTCIWVAGLSVLGVALIIPWGIFTRYALGTGSSWPEPTAILLMLVFTFIGAAASYRAGAHMSVAMITDRLPPVQRRLVGILSQLLMGTICVFMTIWGTKLCLSTWNQFMSAIPTLRVGITYMPIPIGGVLTLVFVVEKLLLGDQSNRKVVRFDLVEENEGAA
>CP023269.1|AVJ23341.1|3797761_3798250_-|Lrp/AsnC-family-transcriptional-regulator
MRKLDRTDIGILNALQENARITNADLARSVNLSPTPCFNRVKAMEELGLIREQVTLLDADLLGLHVNVFIHVSLEKQNELALQQFEGAISDRPEVMECYLMAGDPDYLIRVLVPTIQSLERFMMDFLTKVPGVANIRSSFALKQVRYKTALPLPANGISLGS
>CP023269.1|AVJ23342.1|3798445_3799681_+|3-methyl-2-oxobutanoate-dehydrogenase-(2-methylpropanoyl-transferring)-subunit-alpha
MTQPYAPLRLHVPEPSGRPGCKTDFTYLRLTDAGLVRKPAIDVEPADTADLAKGLIRVLDDKGQALGPWAEGVSTEIMRRGMRAMLKTRIFDNRMVVAQRQKKMSFYMQSLGEEAIGSAQALALNIDDMCFPTYRQQSILMARDVPLVDLICQLLSNERDPLKGRQLPIMYSVKEAGFFTISGNLATQFVQGVGWGMASAIKGDTKIASAWIGDGATAESDFHTALTFAHVYRAPVILNVVNNQWAISTFQAIAGGEATTFAGRGVGCGIASLRVDGNDFIAVYAASAWAAERARRNLGPTLIEWVTYRAGPHSTSDDPSKYRPADDWSHFPLGDPIARLKQHLIKIGQWSEEEHAAVSAELEAEVVKAQKEAEQYGTLAGGQIPSAATMFEDVYKEMPEHLKRQRQELGV
>CP023269.1|AVJ23343.1|3799682_3800741_+|alpha-ketoacid-dehydrogenase-subunit-beta
MNDHNNSIELETAMTTTTMTMIQALRSAMDVMLERDDNVVVFGQDVGYFGGVFRCTEGLQTKYGSSRVFDAPISESGIVGVAVGMGAYGLRPVAEIQFADYVYPATDQIISEAARLRYRSAGQFTAPLTMRMPCGGGIYGGQTHSQSIEAVFTQVCGLRTVMPSNPYDAKGLLIASIENDDPVIFLEPKRLYNGPFDGHHDRPVTPWSKHPQAQVPDGYYTVPLDVAAIVRPGSAVTVLTYGTTVYVSQVAAEETGIDAEVIDLRSLWPLDLETIVKSVKKTGRCVVVHEATRTCGFGAELVSLVQEHCFHHLEAPIERVTGWDTPYPHAQEWAYFPGPSRVGAALKRVMEV
>CP023269.1|AVJ23344.1|3800741_3802007_+|branched-chain-alpha-keto-acid-dehydrogenase-subunit-E2
MGTHVIKMPDIGEGIAEVELSVWHVKVGDLVVEDQVLADVMTDKAMVDIPSPVHGKVISLGGEPGEVMAVGSILISIEVEGAGNTKDMPEVAEPAKAAPPVAEAKPVQAPVESKPAAAVKAPQAPVAREASERPLASPAVRKHALDAGIQLRLVQGTGPAGRILHEDLEAYLRQGPTTAASAANPYAERTDEHQIPVIGMRRKIAQRMQDATRRAAHFSYVEEIDVTALDELRVHLNEKHGATRGKLTLLPFIVRAMVVALRDFPQINARYDDEAQVITRLGAVHVGVATQSDVGLMVPVVRHAEARSLWGTAEEIARLANAARTGKASREELSGSTITLTSLGALGGIVSTPVLNLPEVAIVGVNRIVERPMVIKGQIVVRKMMNLSSSFDHRVVDGMDAAQFIQAIRGLLEQPASLFLE
>CP023269.1|AVJ23345.1|3802011_3803391_+|dihydrolipoyl-dehydrogenase
MTQTLHTTLLIIGGGPGGYVAAIRAGQLGIPTILVEGQALGGTCLNIGCIPSKALIHVAEQFQQTVHHSQGSQLGIEVDVPTLDIRKSVEWKDGIVDRLTTGVAALLKKHKVQVIHGWAKVIDGKTVEVGEQRIQCEHLLLATGSTSVNLPMLPIGGPIISSTEALAPTRVPKRLIVVGGGYIGLELGIAYRKLGADVSVVEAQAHILPAYDAELTLPVAESLKKLGVKLYLEHSVTGFADNKLQVRAPNGDTLALDTDQVLVAVGRKPNTQGWNLEALNLDMNGAAIKIDSRCQTSMRNVYAIGDLSGEPMLAHRAMAQGEMVAELISGKAREFNPAAIPAVCFTDPELVVVGKTPDEAKAAGLDCIVSSFPFAANGRAMTLESKAGFVRVVARRDNHLIVGWQAVGAGVSELSTAFGLSLEMGARLEDVAGTIHAHPTLGEAVQEAALRALGHALHL
>CP023269.1|AVJ23346.1|3803594_3804614_+|branched-chain-amino-acid-aminotransferase
MGNESINWDKLGFDYIKTDKRFLQVWKNGEWQAGTLTDDNVLHISEGSTALHYGQQCFEGLKAYRCKDGSINLFRPDQNAARMQRSCGRLLMPQVPTDAFIDACKQVVKANERFIPPYGSGGALYLRPFVIGTGDNIGVRTAPEFIFSVFCIPVGAYFKGGLVPHNFQISGYDRAAPQGTGAAKVGGNYAASLMPGSEAKKSGFADAIYLDPMTHSKIEEVGSANFFGITHDNQFITPKSPSVLPGITRLSLIELAQTRLGLEVVEGEVFIDKLDQFKEAGACGTAAVISPIGGIQYNGKLHVFHSETEVGPITQKLYKELTGVQTGDVEAPAGWIVKV
>CP023269.1|AVJ23347.1|3804750_3805644_-|GNAT-family-acetyltransferase
MSTAVRLAQPSDAEGISQVILAALHSSNARDYPADVIARVASNFTPDAVMALLQRRVVLVATQDQLIVATAALDGNVVRSVFVNPALQGQGIGRLLMIEIELRAREAGVTVLSVPSSLTAQAFYAKLGFHNVRDVYHGNERTLVMEKALLSRHPIGPYRDRQHRAQVIELWQQAFGYDTAHNLPSLAIDKKLAVNDGLFFVATDNKAVIGTILAGYDGHRGWLYSVAVHTDYRRHGLGSSLVRYAEQALTALGCMKINLQITGGNDVVVGFYEALGYGVEPRISMGKKIAENITPRS
>CP023269.1|AVJ23348.1|3805867_3806794_+|amidinotransferase
MQTTNTVLMIRPARFAFNPDTAINNRFQRPPLDPLSAQHKALEEFDGYVDTLRQHGVEVLVVQDTPAPHTPDSIFPNNWWSSHADGSLVLYPMEGQNRRLERNKGVLQVLEQRFAINTTIDLSHLEQQNIFLEGTGSMVLDRQHRISYACHSGRTHHAALRQFAERLDYQLCVFHALDRHQAPIYHSNVMMSVGRDLAVVCLQALPDDSERLALERSLRDTGKDILSLDFDQLEAFAGNMLEVHDRDGQPLLVMSASAWGALHPEQRQHVERHTRPVVVNIDNIERIGGGSARCMLAEVHLPARHSFQ
>CP023269.1|AVJ23349.1|3806805_3807852_+|ornithine-cyclodeaminase
MTRYIDVNDLSYLVSQKGLQTCITEMADYIRADYLRWQDFEKCARLANHSPDGVIELMPVSDASLYAFKYVNGHPKNTLAGMLTVMAFGALGDVDTGKPVLLAEMTLTTAIRTAATSALVARYLARANSRSMALIGNGCQSEFQALAFHAMLGITEIRLFDIDPQATAKLAANLKAFPAIKVILAASVAEAVKGADIVTTVTADKAYATILTDEMIEPGMHLNAVGGDCPGKTELDRRIVERARVIVEYEPQSRIEGEIQHMPEDSPVTELWQVINGQQPGRENERQITLFDSVGFAIEDYSALRYVLDVAKALDVGSELELVPDLADPKDLFARLAQQPVVQHKKRA
>CP023269.1|AVJ23350.1|3808079_3808859_+|ABC-transporter-substrate-binding-protein
MTPLRSLFAALLLPLCATAAHAQDWKEIRFGVFPEYPPFESVAADGSLQGFDIELGNAICAKLEVKCTWVHNEFDGMIPALRARKFDAIMSSMAVTPAREKVIDFTDRLFLSPTSVITRKNATFGDTPESLNGKQVGVLQGSLQEAYARAHLAKLGAQIKAYQSQEQNYADLQNGRLDATLTDKLEAQLNFLSKPEGADFKTGPAFKDPTLPLDIAMGLRKNDQALRELINKGIAAVQADGTYAQIQKKYFGDQDIYNE

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Crispr_ID: CP023269_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023269_9

3830774-3830868

Orphan

Consensus_repeat	Method
GCAAGCCCGCTCCCACAGTTTGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023269_9

>merge|CP023269|9|3830774-3830868|CRISPRCasFinder
GCAAGCCCGCTCCCACAGTTTGATTGCGGGGTGTCAGGTAGAGAAGCGTCGGCTGAAAGGCCGCCATCGCAGGCAAGCCCGCTCCCACAGGTTTG

>CP023269|9|9|3830774-3830868|CRISPRCasFinder
GCAAGCCCGCTCCCACAGTTTGA	TTGCGGGGTGTCAGGTAGAGAAGCGTCGGCTGAAAGGCCGCCATCGCAG
GCAAGCCCGCTCCCACAGGTTTG

Protein	Signature genes	Signature genes Name	Protein_function
CP023269.1\|AVJ25553.1\|3821161_3821917_+\|proteinase	unknown	unknown	gnl\|CDD\|211851
CP023269.1\|AVJ23375.1\|3836242_3837235_-\|ribose-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|181922
CP023269.1\|AVJ23364.1\|3825155_3826166_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119323
CP023269.1\|AVJ23378.1\|3839990_3840662_+\|fatty-acid-hydroxylase	unknown	unknown	gnl\|CDD\|178053
CP023269.1\|AVJ23366.1\|3826911_3827607_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213191
CP023269.1\|AVJ23368.1\|3828885_3830289_+\|amidase	unknown	unknown	gnl\|CDD\|180437
CP023269.1\|AVJ23365.1\|3826162_3826912_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213186
CP023269.1\|AVJ23370.1\|3830912_3831776_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
CP023269.1\|AVJ23363.1\|3824293_3825154_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
CP023269.1\|AVJ23362.1\|3823033_3824236_+\|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380668
CP023269.1\|AVJ23373.1\|3833602_3835135_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|198372
CP023269.1\|AVJ23377.1\|3838772_3839696_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380544
CP023269.1\|AVJ23376.1\|3837200_3838709_-\|ribonucleotide-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|224053
CP023269.1\|AVJ23371.1\|3831834_3832839_+\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224525
CP023269.1\|AVJ23374.1\|3835137_3836217_-\|erythritol/L-threitol-dehydrogenase	unknown	unknown	gnl\|CDD\|176218
CP023269.1\|AVJ23361.1\|3822029_3822797_+\|FadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
CP023269.1\|AVJ23367.1\|3827620_3828889_+\|Zn-dependent-hydrolase	unknown	unknown	gnl\|CDD\|237250
CP023269.1\|AVJ23372.1\|3832835_3833561_-\|short-chain-dehydrogenase	unknown	unknown	gnl\|CDD\|180817
CP023269.1\|AVJ23360.1\|3819641_3821054_+\|RND-transporter	unknown	unknown	gnl\|CDD\|273830
CP023269.1\|AVJ23379.1\|3840727_3842164_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP023269.1\|AVJ25553.1\|3821161_3821917_+\|proteinase	gnl\|CDD\|211851	TIGR03611, RutD, pyrimidine utilization protein D. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the hydrolase, alpha/beta fold family defined by pfam00067.	0.00882304
CP023269.1\|AVJ23375.1\|3836242_3837235_-\|ribose-ABC-transporter-permease	gnl\|CDD\|181922	PRK09512, rbsC, ribose ABC transporter permease protein; Reviewed.	6.92388e-94
CP023269.1\|AVJ23364.1\|3825155_3826166_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	5.24044e-74
CP023269.1\|AVJ23378.1\|3839990_3840662_+\|fatty-acid-hydroxylase	gnl\|CDD\|178053	PLN02434, PLN02434, fatty acid hydroxylase.	4.78346e-06
CP023269.1\|AVJ23366.1\|3826911_3827607_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213191	cd03224, ABC_TM1139_LivF_branched, ATP-binding cassette domain of branched-chain amino acid transporter. LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.	7.35748e-114
CP023269.1\|AVJ23368.1\|3828885_3830289_+\|amidase	gnl\|CDD\|180437	PRK06169, PRK06169, putative amidase; Provisional.	0
CP023269.1\|AVJ23365.1\|3826162_3826912_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	2.73461e-109
CP023269.1\|AVJ23370.1\|3830912_3831776_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.61534e-33
CP023269.1\|AVJ23363.1\|3824293_3825154_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	8.56226e-67
CP023269.1\|AVJ23362.1\|3823033_3824236_+\|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380668	cd20378, PBP1_SBP-like, periplasmic substrate-binding domain of active transport proteins. Periplasmic substrate-binding domain of active transport proteins found in bacteria and Archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.	0
CP023269.1\|AVJ23373.1\|3833602_3835135_-\|hypothetical-protein	gnl\|CDD\|198372	cd07804, FGGY_XK_like_1, uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases. This subgroup is composed of uncharacterized bacterial and archaeal xylulose kinases-like proteins with similarity to bacterial D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17), which catalyze the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. The presence of Mg2+ or Mn2+ is required for catalytic activity. D-XK exists as a dimer with an active site that lies at the interface between the N- and C-terminal domains. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	0
CP023269.1\|AVJ23377.1\|3838772_3839696_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|380544	cd06321, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of uncharacterized ABC-type transport systems. This group includes the periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consist of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	1.11242e-105
CP023269.1\|AVJ23376.1\|3837200_3838709_-\|ribonucleotide-diphosphate-reductase-subunit-alpha	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
CP023269.1\|AVJ23371.1\|3831834_3832839_+\|LacI-family-transcriptional-regulator	gnl\|CDD\|224525	COG1609, PurR, Transcriptional regulators [Transcription].	1.64543e-83
CP023269.1\|AVJ23374.1\|3835137_3836217_-\|erythritol/L-threitol-dehydrogenase	gnl\|CDD\|176218	cd08256, Zn_ADH2, Alcohol dehydrogenases of the MDR family. This group has the characteristic catalytic and structural zinc-binding sites of the zinc-dependent alcohol dehydrogenases of the MDR family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.	0
CP023269.1\|AVJ23361.1\|3822029_3822797_+\|FadR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	1.63719e-38
CP023269.1\|AVJ23367.1\|3827620_3828889_+\|Zn-dependent-hydrolase	gnl\|CDD\|237250	PRK12893, PRK12893, Zn-dependent hydrolase.	0
CP023269.1\|AVJ23372.1\|3832835_3833561_-\|short-chain-dehydrogenase	gnl\|CDD\|180817	PRK07060, PRK07060, short chain dehydrogenase; Provisional.	7.27899e-117
CP023269.1\|AVJ23360.1\|3819641_3821054_+\|RND-transporter	gnl\|CDD\|273830	TIGR01845, Outer_membrane_protein_OprM, efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family. Members of this model comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined. [Cellular processes, Detoxification, Transport and binding proteins, Porins].	5.86359e-86

>CP023269.1|AVJ23368.1|3828885_3830289_+|amidase
MSEIGQLTAVQLLQHFRDKTLSPVEVTEDALLRIERYNPAVNAYCHVDPQGALDAARTSEQRWFKGEPCGALDGVPASIKDLTLTVGMPTRKGSRTSSAEGPWDVDAPFSAFMRKAGAVLLGKTTTPEFGWKGVTDNPLYGITRNPWDTRTTAGGSSGGAAAAAALNLGVLHQGSDAGGSIRIPCAFTGTFGIKPTFGYVPQWPASSMTILSHLGPMTRTVQDSVLMLQAVARPDARDGLIGAPRTTPWLVPGTDLKGLRVAYSPTFGYVKVDPQVAQVVDQAVQGLVQLGAHVEQIDPGFSDPLDVFSTLWAAGAARLTGTMSEAQRQLLDPGLLRIAQRGERLSLDNFNAALEARAALVARMAAFHEHYDVLVSPMMPITAFEAGHNVPPGSGMTEWMEWTPFTYPFNLTQQPAASVPCGLAANGLPVGLHVVGARFADEQVLRVCHAYAQAFPTAHLHTPKIPT
>CP023269.1|AVJ23367.1|3827620_3828889_+|Zn-dependent-hydrolase
MNSLAQPLQSDAPLINRDRLWQSLMDLAQLGATAKGGVCRLALTDLDRQARDLFVQWCEAAGCSVSVDAIGNIFARRPGRNPTLPPVMTGSHIDTQPTGGKFDGCYGVMAGLEVIRTLNDLQIETQAPIEVVVWTNEEGSRFPPCMMGSGVFAGKFDLQETLDKLDDQGLSVGSELQRIGYAGARAVLGHPVGAYFEAHIEQGPVLEDQAITLGVVMGCLGQKWFDLTLTGVEAHAGPTPMHLRKDALVGAAEVVSAVNRIAHQHQPHACGTVGCLNLHPGSRNVIPGQVHMTIDLRHLHADKLQAMVDEVRAVIEDAAARHGLTFELTPTADFPPLDFHPACVNAVREAAQALGLSHMDIVSGAGHDAIFVAELGPAGMIFVPCEGGISHNEIENAAPDDLAAGCAVLLRAMVNAAQGVPA
>CP023269.1|AVJ23366.1|3826911_3827607_+|ABC-transporter-ATP-binding-protein
MLIVENIHSYYDKSHVLEGVSLSVNPGELVTLLGRNGAGKTTTLRSILGIICPRQGQIHFNGQALVGQKIFEIARQGLALVPENRGIFRLLTVEENLRIAARKHSRWQLEDVYAMFPRLKERRKNAGHALSGGEQQMLAIARALLNDPKLLILDEPTEGLAPVIVDELVKILRKVKDEGLPVLLVEQNLMVCDKLADRHYVLEQGRVVYEGSAADFRADPTIKNRYLALSA
>CP023269.1|AVJ23365.1|3826162_3826912_+|ABC-transporter-ATP-binding-protein
MSILLETQNLELAYGAFHAVNGVNLKVEAGTIHTIIGPNGAGKTSLFHCLTGERQATAGAIHFDGKNLMRKPAHGRVGLGMARSFQLTSLFQNLSVRENLRLAAQGRDGSRALNFWRRVDSQREHLEMADQVLERLQLTARADTLAGELSHGQQRVLEVGMSICSKPKLLMLDEPTSGMGIDDIPIMTQLISDLGRDHTVLLIEHNMSIVMSISQRITVMSHGQILVEGTPEFVRADERVRTAYLGEAA
>CP023269.1|AVJ23364.1|3825155_3826166_+|branched-chain-amino-acid-ABC-transporter-permease
MSDKNPLPFAKTQSRAMLLWVLAVLIGLPLVLPSATLATEILIFAMAALACNLLLGYTGLLSFGQGIFFGAGAYCAALLMIHLQLGLFTALLGAAIAGGFLALLVGALAIRRTGIYFVMLTLAFSQMAYFVAYTLSDWTGGDNGLLSVPRPEIRVGDTVLLSLTDARAFYGFVAVLFLLIFIGARRVIASPFGSTLMAIRENETRASAIGYDTRHFKILVFVLSGAVTGIAGALYAMLLHFVPLSNIDLAMSENILIMTIVGGTGSLFGSLLGAGSIVLLGDFLSDLWPRWLMLLGVILILVVIFMRGGLWGGLASLFEKVRGARKPAVVAKEDGL
>CP023269.1|AVJ23363.1|3824293_3825154_+|branched-chain-amino-acid-ABC-transporter-permease
MLNLYLFQILNGLGLGMIYFLIAVGLTIIFGLLNFVNFAHGAFFLLGAYICYTAVSLTGNFWLALLIAPLVVAALAWVIERLLIQRIYHLPHMFQILVTLGIALIIQEASVMIWGPVGKSVAVPELLRGVLVVGDFVYPYYRLFLIVFSGLVGLGLWLLLERTRFGALVRAGSESTETVSLLGTNIFRLFSMTFALGVALAGVAGVLFAPLRGAQPFVGPEILGIAFVVVVIGGMGSFSGALVGGLLVGVVQSLMTTLWPQGASLMIYGAMAVVILVRPYGLFGRA
>CP023269.1|AVJ23362.1|3823033_3824236_+|branched-chain-amino-acid-ABC-transporter-substrate-binding-protein
MQRRTLLKASLTAAAALSLPLSVRSAFAAEPFTFYGLKSMSGAFASYGKFADMGSRLAVQQHAQLLGRPLNYKVIDTEGNAGKAVRKVQEAIAQDGARFFQGCTLSSSALAVAKEVDKVGGVFMTPVGADEVTGKDCNKATFRWSVPTYGAIRETMVPLIKLLPDAKRWYTITPQYVFGEALLEGAKSVLKEHGLEHVGNSYHSLQEQEFSGYLTNAISTKPDVLVLLNFGSQSSNTLRQAVNFGIKERMKVLLVWSAGLDQFQELGSDVLEGVYLGAQYWHQVDTPLNRELVKLTQAKYGINPTYPLAADYISTKVMLDTIIATGSFDGPTVAKALQGLSYEGPTGKESIRAGDHQVIKDYYLLIGKASGDMADKDDLAKVLSAGQSFPAVEATGCTLG
>CP023269.1|AVJ23361.1|3822029_3822797_+|FadR-family-transcriptional-regulator
MLTRPLRRKRQKLSDVIVESVKRSIVTDALKPGDRLPTERELMESFQCSKGSAREALKALEVEGLVSTRTGPSGGAYLNQAGTEPASRALRNYLHFQHLDGEQVYQLRKVIEVELAVSVLGRLSENDYTALQANVDFCSAPEDSEAGQREQRLAELEFHNLLARACPNPLLSFMAQFLNDLLRDLVVLKKAYKPKRKQFDAANLDYHKQLLIAFRAGDESAVRSLMHEHMCDAEHHMTALEGQVSPHFLLEFDHP
>CP023269.1|AVJ25553.1|3821161_3821917_+|proteinase
MKPSVVVKGLACIGCWLIPNLALAKPLIAPTAIDWLLDCPLTTTAHLNPQVVGRTQCGLVNVPRDHAAPQRGRLSLSVTRVGARQPLNREGVVFIQAGEPLQAKDAPFVLHLASRWESLATQAYRTLVDRYDVIELSARDLREGNAVEQAARDMEFVRGQLDEARLNYLGNAAATRLGSRYGTLFPERVGRMVLINAEPGEAVATGVEQLLLKESARAGADGCVNRWLGDFLAYGRQPPASTRCLDLSAWE
>CP023269.1|AVJ23360.1|3819641_3821054_+|RND-transporter
MNKRSITPPLSALSLCLLLTACGANPPAIDSGLAAPATWHYAEREATQAINQRWWTQFGSPALNRLIDQARRDSFDVAAAMARVRQAQATAVIAGAPLLPELKFNLTASRQRLLRGSGNSDLDATESNRTVNSYDASLTASYEIDFWGGRAAARDSAVHSLHASEFDQANVELTLLSNVADRYAQTLAARQRLQIAELNLANARNVLNLVQTRHDAGSATALELAQQKSLVASQQRQLPLIQQSVEESQITLAALLGQPVQALELGAEPFQALTWPSIGPGVPSQLLSRRPDLAQAEAQLAAARADVTVARAAMLPSVTLGATLGSGAYKAQEVLRSPFYTLTSGLMAPIFNNGRLSAERDKARARQDELLQTYRGAIINGFADVEKALSSITRLDQQRQWQSEELQQAQTAFQIAQSRYEAGAEDLLTVLETQRTLYGAQDQNVLLRLSRLQASIALYKALGGGWKTNI
>CP023269.1|AVJ23370.1|3830912_3831776_+|LysR-family-transcriptional-regulator
MDIELARTFLEITRCGSLAAAAEKLHVTQTAITARVKNLENQLGCTLFVRNRAGARLTADGEAFVVYANQLLQTWEAARRDLPLPDGYRNVLHIGGEVSLCNPLMLGWAKALREQIPGHALRTEVREGEYLLRQLELGVLDAALVFQPQYWPGLQVEQVLEEKLILVQLASKPSPYVYIDWGQGFRQQHDAALPDRARAALSFNLGPLALQYILENGGAGYFRTRVVQSYLDSGVMQRVPKAPEFSFPTYLVYSRARDSAVLQQALELLREVVKAEGDWSQRWDPLI
>CP023269.1|AVJ23371.1|3831834_3832839_+|LacI-family-transcriptional-regulator
MNKKKSVTISDIAKRVGMTTITVSRALSKPDLVKPATLARILEVARELDYVPNAFARGLKRSESLIIGVITASVDNPFYSEMIKAISREAKKHGYTIMLVDTDELEELESKAVDTLLGYRVAGIILSPVSDEPSYQPDYLERLGNGKTPVVLLDRTIHDSPFSRVVLDNYHSGLQAAHYLLRQTPNLKRLLVLTGPEHSRISVERLKGLREVLAEHPDIQVEVQAGDYTLMPAYLHTLDYLAAHSAPDAIMGFNQLITLGALRALRMHNIAHDSLTICGIDRLPFADIFGVPIACVAHDASLAGSSAVRLLLDRLQDPHKPRDKVVIAGQLENG
>CP023269.1|AVJ23372.1|3832835_3833561_-|short-chain-dehydrogenase
MSTTFDFSYQRILVTGASSGIGREIAQQLIASGAEVFALGRDAQALAALGCRTLCVDIADSIALDKTLQDLPPLHGLVNCAGISRLEPAAAISANAFDQVMHVNARAAAQVASRVAAKMIEANMAGSIVNVSSQASLVALDDHLSYCASKAALDAITRVQCAEWGRFGIRVNSVNPTVTLTPMAAMAWSDPAKRDPALAAIPLGRFAQPVEVALPVLFLLSDAASMISGVSLPVDGGYTSR
>CP023269.1|AVJ23373.1|3833602_3835135_-|hypothetical-protein
MDYVIGVDIGTQSTKALLVDAQGTIIAQHSQGYRVDTPKVRWAEQWPQVWLDAVETCVAQCMAKAGVPAPQVKALCISSLYGGSGIAVDAQMTPLHPCLIWMDRRAGEQVAWVREHVDLERLFAITGNSLDSYYGFTKMLWLKQHQPQVWANTRYLLPPNSYINWCLTGELAVDHSSAGNIGGVYDVAARNWSGEMLDALGIAQSMMPERLLYSGEVVGGLLADWAARLGLQAGTPILAGGVDAAMATLAAGVTQPGNHVAMIGTSMCWGYLNQQVDARHGLVSMPHVYNGHRDLYIFGGAITAGASVSWFREQFCQAEEQQAQATGQDSLALLEQSAMKIPAGSEGVVFLPYLMGERSPVWDDRASGSFVGLNLYHSRFHLYRAVLEGVSFALRHNIEAGSQGAHSLDPRLIVVGGASHSDLWMQIIADVTRYPVYTIVQEVEAALGAALLAAHTMGLVSDGQMDTGWVQLQLRAQPKRENVMTYDRAFAEYLKLYPALKPVMHNLQST
>CP023269.1|AVJ23374.1|3835137_3836217_-|erythritol/L-threitol-dehydrogenase
MDKHTHMQAVVCHGPKDYRLERIGKPQARANELVIRIAACGICASDCKCHSGAAMFWGGDNPWVKAPVVPGHEFFGYVVEAGEGAEEHFEVKVGDKVIAEQIVPCGKCRFCKSGKYWMCEVHNIFGFQREVAEGGMAQYMRIPKTAIVHKIPESVSLEDSALVEPMACSIHTVNRGDIQLDDVVVIAGAGTLGLCMVQVAALKTPKKLVVIDMVDERLELAKKFGADVVINPARDNAREIINGLTDNYGCDVYIETTGVPAGVTQGLDLIRKLGRFVEFSVFGAETSVDWSIIGDRKELDVRGAHLGPYCYPIAIDLFERGLVTSQGIVTHDFPLDDWAEAFELANSTKSIKVLLKPVL
>CP023269.1|AVJ23375.1|3836242_3837235_-|ribose-ABC-transporter-permease
MQQGAQVNTSINTAGNGRLRLNLARLLRSPAFYPFVGLVVVTLVMILASDTFLTASNLSNIARQVSINAIIAVGMTCVILTGGIDLSVGPVMALSGTLTAGLMVAGLPPGLAIGAGLLVGVAFGIGNGLFVAYLHMPPIIVTLATMGIARGFGLMYTDGYPISGLPEWFAFFGRASVFGLQVPILIMLITYLAAYVLLQHTRIGRYIYAIGGNEEAVRLSGVRAARFKLLVYGISGFTAAIAGLVLTSRLMSGQPNAGVSFELDAIAAVVLGGASIAGGRGVIIGTLLGAMLLGVLNNGLNMLGVSPYVQSVIKGGIILLAIFISRQRHR
>CP023269.1|AVJ23376.1|3837200_3838709_-|ribonucleotide-diphosphate-reductase-subunit-alpha
MSSLLKLENICKRYPGVQALKAINLQVERGEIHALLGENGAGKSTLMKILGGVEHQDEGQILIDGQARKFATYRDAIAAGIGIVFQEFSLIPYLTAVENIFLGHELSNRFGLLRKREMAEAAQALFERLGVSIDLHCAVKHLSVAEQQFVEIAKALALDARLLVLDEPTATLTPSEAELLFGIMRELKRQGVAVIFISHHLEEIFQICDRISVLRDGGNAGVTEVADSDIDHLVEMMVGRRLECSFPPKPTTARGPLLLEVKDIQLVRNGPHNRFNVHKGEILGFAGLVGSGRTELALGMMGALPTVSKDVWLRGEKVSLDDPAQALACGIGLLPESRKSEGLITAFSIRENISLNNLPKYQHASGLIDKARECASVEALMRQLSIKAPSGESLVVNLSGGNQQKVVIARWINHHCDVLVFDEPTRGIDVGAKAQIYALMRSLTEQGYAIIMISSELPEVIGMCDRVAVFHKGAIVKVLEASAVNPQEVMRHATGGSSEYVH
>CP023269.1|AVJ23377.1|3838772_3839696_-|LacI-family-transcriptional-regulator
MKMLPKTLCLLAASITLGSATPAFADAAKPIRIGASFQEINNPYFVTMKNALEEAGATIGAKLIITDARHDVSKQVSDVEDMLQKGIDILLINPTDSVGVQSAVKSAHAAGVVVVAVDAQADGPLDSFVGSKNFDAGFQACEYLAKTIGDKGNIAILDGIAVVPILERVRGCKEAVAKHPDIKIVSIQNGKQERDQALTVTENMLQAQPTLKGIFSVNDNGSLGALSAIEASGMDVKLVSVDGAPEAIKAIQKPGSHFIATSAQYPRDQIRLALGIALAKKWGAQVPASVPVDITLIDQAKAKDFSW
>CP023269.1|AVJ23378.1|3839990_3840662_+|fatty-acid-hydroxylase
MPHPTETFRDRYRASVNPRYNPWLHAAFVLGYGIACITLAWSSTADITALQWLTVPLTLLFFNLCIYLVHRHLGHHKHAFARLFYARHTGDHHSFFTPGHMTYDSPRDWRVILFPAWLIMLHSLAITLPAWWLLSQLSPNVAGLFAGCMILGYLLYEVFHACEHLPAEHPVARLPWIRQMHRLHALHHRRELMQGRNFNIVLPLMDYLFGTLYWEPRPPDSQK
>CP023269.1|AVJ23379.1|3840727_3842164_-|hypothetical-protein
MKSKIAFMLGAAMMASCFVSAFALADQAPAKLSAEAVKQAVNKALKSGGKLDASKVSTELKKKLLVAKSGQSKAVTRSLKSEPFDSVVSELKKPAQGALKGAAIAAFEPLFPTLDINTLYTVDAVQAGNEFAYHFNLPQNARVQVQLVNQSAGADMSLTLFQDDGQGNLSVVGSSDAAGNADEYLNGVLPAGDYYWYMVAKVADNAQFSFGVAVDSNIDAFEPNDSAQTAFVLPDSMNKVSGNLDSANDVDYFDFTAVRGQSVSMYLAGDENGSRNQWIFDRFDGANWVTVPAGSTSTYPSVAPGTTVKVRVRANPAVAQDPSKYYQLSLGSTPRLNTSSVKGDNIVRVTEVWLATQTARLLNWSTQWSDSTGAPLLGVTPVLRVDNHFVDLNYRWVDYKATTNSAGVSEATANIGTCFGDYTTVINDSSTGVPYKWRTTYNEGGWRIELAEFPGVGVGGENVQYVSLGHICTQDIIH

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

904520 : 948791

Pseudomonas_phage(45.45%)

capsid,terminase,integrase,lysis,holin

attL 905054:905076|attR 948989:949011

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVJ20954.1\|904520_904934_+	prepilin-type cleavage/methylation domain-containing protein	A0A0E3FBU3	Synechococcus_phage	4.8e-07	40.9
905054:905076	attL	NA	NA	NA	NA
AVJ20955.1\|905238_906450_+\|integrase	integrase	A0A0U1UNT3	Pseudomonas_phage	8.6e-113	52.9
AVJ20956.1\|906419_906659_-	AlpA family transcriptional regulator	Q7M299	Enterobacteria_phage	3.3e-08	45.2
AVJ20957.1\|906720_907110_-	hypothetical protein	NA	NA	NA	NA
AVJ20958.1\|907278_907524_-	hypothetical protein	NA	NA	NA	NA
AVJ20959.1\|907520_907769_-	hypothetical protein	NA	NA	NA	NA
AVJ20960.1\|907814_908351_-	hypothetical protein	A0A0H4INT9	Pseudoalteromonas_phage	6.6e-17	36.8
AVJ20961.1\|908404_908851_-	hypothetical protein	NA	NA	NA	NA
AVJ20962.1\|908847_909159_-	DUF4406 domain-containing protein	A0A2K8I958	Pseudomonas_phage	1.4e-19	48.0
AVJ20963.1\|909155_909587_-	hypothetical protein	NA	NA	NA	NA
AVJ20964.1\|909641_910676_-	DNA cytosine methyltransferase	A0A2I7QZY6	Vibrio_phage	1.8e-55	62.3
AVJ20965.1\|910816_911212_-	hypothetical protein	I6WLM5	Burkholderia_virus	2.9e-25	52.3
AVJ20966.1\|911666_912023_-	four helix bundle protein	NA	NA	NA	NA
AVJ20967.1\|912077_912698_-	DUF1566 domain-containing protein	A0A2I6PHV0	Pseudomonas_phage	2.9e-08	35.2
AVJ20968.1\|912777_913389_-	DUF1566 domain-containing protein	NA	NA	NA	NA
AVJ20969.1\|913446_913932_-	hypothetical protein	A0A1B0VMB5	Pseudomonas_phage	8.0e-70	85.0
AVJ20970.1\|914001_914472_-	hypothetical protein	A0A2H4J101	uncultured_Caudovirales_phage	5.7e-73	88.1
AVJ20971.1\|914468_914711_-	hypothetical protein	A0A2H4J1H1	uncultured_Caudovirales_phage	1.0e-33	95.0
AVJ20972.1\|914718_915282_-	hypothetical protein	A0A2H4IZG3	uncultured_Caudovirales_phage	1.7e-68	72.7
AVJ20973.1\|915278_916016_-	hypothetical protein	A0A2H4J2D5	uncultured_Caudovirales_phage	3.3e-75	58.4
AVJ20974.1\|916018_916423_-	hypothetical protein	A0A2H4J0K7	uncultured_Caudovirales_phage	1.4e-43	58.3
AVJ20975.1\|916577_916820_-	hypothetical protein	NA	NA	NA	NA
AVJ20976.1\|916950_917211_-	hypothetical protein	NA	NA	NA	NA
AVJ20977.1\|917207_917483_-	hypothetical protein	A0A2H4J6R2	uncultured_Caudovirales_phage	5.1e-13	47.9
AVJ20978.1\|917502_917937_-	hypothetical protein	W6MVG2	Pseudomonas_phage	2.5e-51	65.1
AVJ20979.1\|917958_918213_-	hypothetical protein	NA	NA	NA	NA
AVJ20980.1\|918241_918544_-	hypothetical protein	A0A1B0VM52	Pseudomonas_phage	2.4e-08	83.3
AVJ25450.1\|919050_919293_-	hypothetical protein	NA	NA	NA	NA
AVJ25451.1\|919330_919525_-	hypothetical protein	NA	NA	NA	NA
AVJ20981.1\|919772_920231_+	hypothetical protein	NA	NA	NA	NA
AVJ20982.1\|921002_921257_-	hypothetical protein	NA	NA	NA	NA
AVJ25452.1\|921256_921919_-	Repressor protein CI	H2BDH4	Pseudomonas_virus	2.4e-64	57.3
AVJ20983.1\|922026_922245_+	transcriptional regulator	A0A127KNT2	Pseudomonas_phage	1.3e-11	47.9
AVJ20984.1\|922247_922559_+	transcriptional regulator	H6WRX6	Salmonella_phage	3.6e-15	51.7
AVJ20985.1\|923145_924048_+	helix-turn-helix domain-containing protein	A0A1B0VME0	Pseudomonas_phage	1.1e-72	91.3
AVJ20986.1\|924034_924823_+	hypothetical protein	A0A1B0VMD9	Pseudomonas_phage	4.0e-103	76.1
AVJ20987.1\|924815_925403_+	DUF1367 domain-containing protein	Q9MC49	Pseudomonas_phage	5.1e-95	85.1
AVJ20988.1\|925399_926011_+	hypothetical protein	A0A059VA66	Pseudomonas_phage	1.4e-58	59.3
AVJ20989.1\|926007_926370_+	hypothetical protein	W6MVN8	Pseudomonas_phage	1.4e-31	59.0
AVJ20990.1\|926366_926546_+	hypothetical protein	A0A1J0MGJ9	Serratia_phage	4.3e-05	42.6
AVJ20991.1\|926685_926958_+	hypothetical protein	NA	NA	NA	NA
AVJ20992.1\|927052_927304_+\|holin	holin	A0A0U1UNM6	Pseudomonas_phage	1.9e-14	55.6
AVJ20993.1\|927300_927816_+	lysozyme	I6X6V3	Burkholderia_virus	2.0e-58	64.9
AVJ25453.1\|927842_928250_+	hypothetical protein	A0A2H4J3Y5	uncultured_Caudovirales_phage	1.6e-42	68.5
AVJ20994.1\|928246_928603_+	hypothetical protein	A0A0U4ISD3	Pseudomonas_phage	1.1e-23	45.3
AVJ20995.1\|928614_929073_+\|lysis	lysis protein	B5TK84	Pseudomonas_phage	2.6e-06	37.8
AVJ20996.1\|929069_929282_+	hypothetical protein	NA	NA	NA	NA
AVJ20997.1\|929290_929824_+\|terminase	terminase small subunit	A0A1W6JNT5	Morganella_phage	9.1e-59	64.5
AVJ20998.1\|929801_931313_+\|terminase	terminase	K4NWT7	Pseudomonas_phage	2.2e-198	67.4
AVJ20999.1\|931315_931669_+	hypothetical protein	NA	NA	NA	NA
AVJ21000.1\|931616_933365_+	hypothetical protein	K4NWH1	Pseudomonas_phage	1.2e-139	45.1
AVJ21001.1\|933364_933661_+	hypothetical protein	Q858H0	Salmonella_phage	7.6e-07	43.3
AVJ21002.1\|933657_934371_+	peptidase	Q2A089	Sodalis_phage	3.1e-22	39.7
AVJ21003.1\|934400_935396_+\|capsid	phage capsid protein	T1S9H9	Salmonella_phage	6.3e-122	62.2
AVJ21004.1\|935435_935828_+	hypothetical protein	T1SA71	Salmonella_phage	2.1e-44	72.9
AVJ21005.1\|935820_936198_+	hypothetical protein	NA	NA	NA	NA
AVJ21006.1\|936257_936857_+	hypothetical protein	NA	NA	NA	NA
AVJ21007.1\|936853_939196_+	hypothetical protein	K4NWU8	Pseudomonas_phage	1.4e-212	47.2
AVJ21008.1\|939182_939650_+	hypothetical protein	A0A2R2ZGD5	Ralstonia_phage	2.3e-21	38.2
AVJ21009.1\|939652_940123_+	hypothetical protein	K4NYZ0	Pseudomonas_phage	1.3e-21	45.7
AVJ21010.1\|942155_944084_+	hypothetical protein	A0A2H4J9W0	uncultured_Caudovirales_phage	1.9e-66	32.5
AVJ21011.1\|944083_946636_+	hypothetical protein	A0A193GZ61	Enterobacter_phage	5.1e-192	43.4
AVJ21012.1\|946706_948791_+	hypothetical protein	W6MW31	Pseudomonas_phage	1.1e-46	40.8
948989:949011	attR	NA	NA	NA	NA

DBSCAN-SWA_2

1363127 : 1443013

100

Pseudomonas_phage(40.68%)

capsid,plate,integrase,terminase,lysis,tRNA,holin,portal,head,tail

attL 1411059:1411075|attR 1420827:1420843

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVJ21346.1\|1363127_1365179_-\|tRNA	methionine--tRNA ligase	NA	NA	NA	NA
AVJ21347.1\|1365352_1366447_+	iron-sulfur cluster carrier protein ApbC	NA	NA	NA	NA
AVJ21348.1\|1366967_1367291_-	ferredoxin family protein	NA	NA	NA	NA
AVJ21349.1\|1367433_1370013_-	DNA mismatch repair protein MutS	A0A1V0SJ67	Klosneuvirus	5.1e-30	22.0
AVJ25471.1\|1370207_1370912_+	Zeta toxin	NA	NA	NA	NA
AVJ21350.1\|1371091_1372090_-\|integrase	integrase	A0A1B0VP19	Pseudomonas_phage	7.4e-179	94.5
AVJ21351.1\|1372101_1372296_-	hypothetical protein	A0A1B0VMB6	Pseudomonas_phage	1.0e-28	95.3
AVJ21352.1\|1372298_1372745_-	hypothetical protein	NA	NA	NA	NA
AVJ21353.1\|1372913_1373195_-	hypothetical protein	A0A2H4J399	uncultured_Caudovirales_phage	5.9e-09	63.8
AVJ21354.1\|1373191_1373944_-	hypothetical protein	NA	NA	NA	NA
AVJ21355.1\|1374582_1375017_-	tellurite resistance protein	Q1MVI3	Enterobacteria_phage	4.0e-28	45.8
AVJ21356.1\|1375019_1375235_-	hypothetical protein	NA	NA	NA	NA
AVJ21357.1\|1375313_1375793_-	hypothetical protein	NA	NA	NA	NA
AVJ21358.1\|1375792_1376359_-	hypothetical protein	A0A0A0RNU5	Citrobacter_phage	5.7e-43	46.3
AVJ25472.1\|1376835_1377216_-	helix-turn-helix transcriptional regulator	A0A0A0YWH0	Pseudomonas_phage	1.9e-10	40.0
AVJ21359.1\|1377379_1378159_-	phage repressor protein C	A0A1B0VRI7	Pseudomonas_phage	2.4e-36	37.1
AVJ21360.1\|1378245_1378551_+	hypothetical protein	NA	NA	NA	NA
AVJ21361.1\|1379108_1379336_+	DNA-binding protein	NA	NA	NA	NA
AVJ21362.1\|1379537_1379786_+	hypothetical protein	NA	NA	NA	NA
AVJ21363.1\|1379794_1380121_+	hypothetical protein	NA	NA	NA	NA
AVJ21364.1\|1380117_1380411_+	hypothetical protein	NA	NA	NA	NA
AVJ21365.1\|1380407_1381142_+	hypothetical protein	A0A2H4JDP7	uncultured_Caudovirales_phage	1.5e-27	61.1
AVJ21366.1\|1381138_1381732_+	hypothetical protein	NA	NA	NA	NA
AVJ21367.1\|1381728_1381956_+	hypothetical protein	A0A0A0YWI1	Pseudomonas_phage	1.9e-18	69.5
AVJ25473.1\|1382516_1382723_+	hypothetical protein	A0A1W6JTD5	Pseudomonas_phage	7.4e-09	46.3
AVJ21368.1\|1382706_1383504_+	ATP-binding protein	A0A1W6JTD8	Pseudomonas_phage	7.2e-68	55.2
AVJ21369.1\|1383500_1384904_+	helicase DnaB	A0A1W6JTB3	Pseudomonas_phage	1.3e-109	44.7
AVJ21370.1\|1384890_1385484_+	hypothetical protein	NA	NA	NA	NA
AVJ21371.1\|1385652_1385952_+	hypothetical protein	A0A1W6JTC1	Pseudomonas_phage	4.4e-18	52.9
AVJ21372.1\|1385951_1386497_+	hypothetical protein	NA	NA	NA	NA
AVJ21373.1\|1386971_1387475_+	hypothetical protein	NA	NA	NA	NA
AVJ25474.1\|1387520_1387838_+\|holin	phage holin, lambda family	Q8SBE1	Shigella_phage	1.5e-13	41.1
AVJ21374.1\|1387834_1388212_+	hypothetical protein	NA	NA	NA	NA
AVJ25475.1\|1388222_1388369_+	hypothetical protein	NA	NA	NA	NA
AVJ21375.1\|1388429_1388645_+	hypothetical protein	A0A2H4J0Y9	uncultured_Caudovirales_phage	4.8e-19	69.8
AVJ21376.1\|1388644_1388824_+	hypothetical protein	NA	NA	NA	NA
AVJ21377.1\|1388887_1389223_+	HNH endonuclease	B5WZZ4	Pseudomonas_phage	1.2e-29	54.1
AVJ21378.1\|1389236_1389761_+	hypothetical protein	A0A2P1JZ90	Mycobacterium_phage	7.2e-16	37.6
AVJ21379.1\|1389866_1390337_+	hypothetical protein	A0A2H4J8R0	uncultured_Caudovirales_phage	3.8e-16	37.7
AVJ21380.1\|1390333_1392031_+\|terminase	terminase	S4TSQ6	Salmonella_phage	7.1e-182	59.6
AVJ21381.1\|1392030_1393431_+\|portal	phage portal protein	A0A0U4IJ43	Pseudomonas_phage	9.6e-225	83.2
AVJ21382.1\|1393446_1394340_+	peptidase	A0A0U4B0J0	Pseudomonas_phage	3.6e-100	64.9
AVJ21383.1\|1394332_1395541_+\|capsid	phage major capsid protein	A0A0U4JIW8	Pseudomonas_phage	1.4e-171	78.5
AVJ21384.1\|1395766_1396108_+	hypothetical protein	Q6JIM5	Burkholderia_virus	2.9e-18	47.4
AVJ21385.1\|1396138_1396429_+\|head,tail	head-tail adaptor protein	A0A2D1GNG1	Pseudomonas_phage	4.1e-13	42.7
AVJ21386.1\|1396425_1396896_+	hypothetical protein	Q3HQT4	Burkholderia_phage	1.2e-25	42.7
AVJ21387.1\|1396902_1397250_+	hypothetical protein	NA	NA	NA	NA
AVJ21388.1\|1397258_1397729_+	hypothetical protein	Q3HQT6	Burkholderia_phage	7.8e-30	47.0
AVJ21389.1\|1397728_1398202_+	hypothetical protein	A4JX08	Burkholderia_virus	5.9e-09	30.8
AVJ21390.1\|1398225_1398528_+\|tail	phage tail protein	Q3HQT8	Burkholderia_phage	1.2e-15	56.9
AVJ21391.1\|1398594_1398951_+	hypothetical protein	NA	NA	NA	NA
AVJ21392.1\|1398988_1402366_+	hypothetical protein	A0A0P0ZCJ4	Stx2-converting_phage	3.4e-82	50.3
AVJ21393.1\|1402365_1402704_+\|tail	phage tail protein	A0A0R6PIG5	Moraxella_phage	2.2e-10	34.9
AVJ21394.1\|1402700_1403387_+\|tail	phage minor tail protein L	A0A0R6PGU8	Moraxella_phage	2.2e-49	42.4
AVJ21395.1\|1403394_1404147_+	hydrolase Nlp/P60	A0A2D1GNP8	Pseudomonas_phage	1.2e-69	53.2
AVJ25476.1\|1404152_1404743_+\|tail	phage tail protein	A0A0P0I3X0	Klebsiella_phage	8.3e-45	51.9
AVJ21396.1\|1404752_1408661_+	host specificity protein	A0A1B0VMH5	Pseudomonas_phage	0.0e+00	45.7
AVJ21397.1\|1408672_1408996_+	hypothetical protein	NA	NA	NA	NA
AVJ21398.1\|1409723_1410497_+\|tail	phage tail protein	A0A0S2SY45	Pseudomonas_phage	2.1e-35	39.7
AVJ21399.1\|1410496_1410787_+	hypothetical protein	A0A2H4J9Z7	uncultured_Caudovirales_phage	5.9e-20	50.5
AVJ21400.1\|1410783_1411035_+	hypothetical protein	C8ZKF3	Pseudomonas_phage	8.4e-15	54.8
1411059:1411075	attL	NA	NA	NA	NA
AVJ21401.1\|1411148_1411694_+	hypothetical protein	A0A2H4P763	Pseudomonas_phage	7.5e-16	35.8
AVJ21402.1\|1411693_1412119_+	cell wall hydrolase	A0A2D1GNI1	Pseudomonas_phage	1.4e-73	91.5
AVJ21403.1\|1412191_1412959_+	restriction endonuclease subunit M	C7BGE1	Burkholderia_phage	5.6e-94	62.5
AVJ21404.1\|1412979_1413216_-	hypothetical protein	NA	NA	NA	NA
AVJ21405.1\|1413613_1414825_+	hypothetical protein	NA	NA	NA	NA
AVJ21406.1\|1414860_1416075_-\|integrase	integrase	A0A1I9KF78	Aeromonas_phage	1.1e-70	40.4
AVJ21407.1\|1416381_1416906_+	hypothetical protein	NA	NA	NA	NA
AVJ21408.1\|1417218_1417500_-	DUF3077 domain-containing protein	NA	NA	NA	NA
AVJ21409.1\|1418409_1418904_-	type II toxin-antitoxin system death-on-curing family toxin	NA	NA	NA	NA
AVJ21410.1\|1420066_1420801_+	transcriptional regulator	B5TK58	Pseudomonas_phage	6.3e-119	87.7
AVJ21411.1\|1421393_1421732_+\|holin	pyocin R2, holin	B5TK61	Pseudomonas_phage	1.4e-44	85.4
1420827:1420843	attR	NA	NA	NA	NA
AVJ21412.1\|1421755_1422271_+	hypothetical protein	NA	NA	NA	NA
AVJ21413.1\|1422274_1422886_+\|plate	baseplate assembly protein	A0A2H4JBW8	uncultured_Caudovirales_phage	3.8e-45	53.3
AVJ21414.1\|1422895_1423228_+\|plate	phage baseplate protein	A0A2H4JI46	uncultured_Caudovirales_phage	8.8e-36	68.2
AVJ21415.1\|1423224_1424220_+\|plate	baseplate J protein	A0A2H4JC04	uncultured_Caudovirales_phage	1.2e-112	63.8
AVJ21416.1\|1424216_1424855_+\|tail	phage tail protein I	A0A2H4JDK0	uncultured_Caudovirales_phage	4.8e-38	51.9
AVJ21417.1\|1424851_1425385_+	hypothetical protein	A2I2X8	Vibrio_virus	1.9e-48	60.4
AVJ21418.1\|1425433_1426051_+	hypothetical protein	NA	NA	NA	NA
AVJ25477.1\|1426102_1426309_+	hypothetical protein	NA	NA	NA	NA
AVJ21419.1\|1426570_1427737_+\|tail	phage tail protein	B0ZSG8	Halomonas_phage	7.2e-125	57.0
AVJ21420.1\|1427736_1428243_+\|tail	phage tail protein	Q6R4W3	Vibrio_virus	2.2e-22	34.5
AVJ21421.1\|1428423_1428996_+	hypothetical protein	B0ZSH0	Halomonas_phage	3.1e-28	39.3
AVJ21422.1\|1429205_1431347_+\|tail	phage tail tape measure protein	NA	NA	NA	NA
AVJ21423.1\|1431346_1431730_+	hypothetical protein	A0A2H4JAC8	uncultured_Caudovirales_phage	1.3e-35	58.3
AVJ21424.1\|1431722_1431935_+\|tail	phage tail protein	A0A2H4JGD9	uncultured_Caudovirales_phage	4.0e-18	65.7
AVJ21425.1\|1431944_1432946_+\|tail	phage tail protein	A0A2H4JH05	uncultured_Caudovirales_phage	7.9e-96	52.4
AVJ21426.1\|1432968_1433526_+	lysozyme	B5TK83	Pseudomonas_phage	4.0e-73	70.5
AVJ21427.1\|1433513_1434008_+\|lysis	lysis protein	A0A2H4IZW4	uncultured_Caudovirales_phage	4.3e-39	60.6
AVJ21428.1\|1434089_1434590_+	CinA family protein	B5TK85	Pseudomonas_phage	1.1e-69	83.1
AVJ21429.1\|1434673_1435732_+	recombinase RecA	A0A0S2MVG1	Bacillus_phage	2.4e-111	62.4
AVJ21430.1\|1435740_1436208_+	regulatory protein RecX	NA	NA	NA	NA
AVJ21431.1\|1436266_1437379_-	TIGR00730 family Rossman fold protein	NA	NA	NA	NA
AVJ21432.1\|1437673_1438108_-	hypothetical protein	NA	NA	NA	NA
AVJ21433.1\|1438286_1439006_+	DTW domain-containing protein	NA	NA	NA	NA
AVJ21434.1\|1439257_1439908_+	DNA-binding response regulator	NA	NA	NA	NA
AVJ21435.1\|1439983_1440346_+	diacylglycerol kinase	NA	NA	NA	NA
AVJ25478.1\|1440349_1441336_-	LysR family transcriptional regulator	NA	NA	NA	NA
AVJ21436.1\|1441401_1442181_+	ferredoxin--NADP reductase	NA	NA	NA	NA
AVJ21437.1\|1442317_1443013_-\|tRNA	tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO	NA	NA	NA	NA

DBSCAN-SWA_3

1549856 : 1554843

uncultured_Mediterranean_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVJ21529.1\|1549856_1550606_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	7.2e-62	49.4
AVJ21530.1\|1550605_1551283_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	3.1e-43	53.1
AVJ21531.1\|1551492_1552329_+	peptigoglycan-binding protein LysM	A0A0S2SXL7	Bacillus_phage	8.2e-06	33.3
AVJ21532.1\|1552435_1553443_+	RNA polymerase sigma factor RpoS	G8CLC7	Synechococcus_phage	1.3e-34	36.2
AVJ21533.1\|1553678_1553888_-	cold-shock protein CapB	Q9AZD3	Lactococcus_phage	2.2e-16	66.7
AVJ21534.1\|1554276_1554843_+	dCTP deaminase	S5VM63	Pseudomonas_phage	3.7e-74	73.3

DBSCAN-SWA_4

3605200 : 3615181

uncultured_Caudovirales_phage(71.43%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVJ25541.1\|3605200_3606025_-\|tRNA	tRNA 2-thiocytidine(32) synthetase TtcA	A0A0U2S5Z2	Escherichia_phage	2.6e-105	71.6
AVJ23186.1\|3606306_3606909_+	YIP1 family protein	NA	NA	NA	NA
AVJ25542.1\|3607037_3607532_+	M48 family peptidase	NA	NA	NA	NA
AVJ23187.1\|3607625_3608801_-	carnitine dehydratase	NA	NA	NA	NA
AVJ23188.1\|3608958_3609351_+	sulfurtransferase complex subunit TusD	A0A2H4JA39	uncultured_Caudovirales_phage	1.9e-58	85.4
AVJ23189.1\|3609352_3609703_+	sulfurtransferase complex subunit TusC	A0A2H4J8C0	uncultured_Caudovirales_phage	2.0e-38	67.8
AVJ23190.1\|3609702_3609981_+	sulfurtransferase complex subunit TusB	A0A2H4JG28	uncultured_Caudovirales_phage	1.2e-25	55.6
AVJ23191.1\|3609977_3610313_+	sulfurtransferase TusE	A0A2H4J8B6	uncultured_Caudovirales_phage	8.0e-45	78.4
AVJ23192.1\|3610309_3611311_+	hypothetical protein	A0A2H4JBY5	uncultured_Caudovirales_phage	1.3e-167	86.3
AVJ23193.1\|3611399_3612395_+	glutathione-dependent reductase	NA	NA	NA	NA
AVJ23194.1\|3612505_3613900_-	uroporphyrinogen-III C-methyltransferase	NA	NA	NA	NA
AVJ23195.1\|3613900_3615181_-\|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	1.8e-97	53.8

DBSCAN-SWA_5

4103046 : 4109441

uncultured_Caudovirales_phage(85.71%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVJ23596.1\|4103046_4103721_-	two-component system response regulator	W8CYM9	Bacillus_phage	1.6e-20	32.9
AVJ23597.1\|4104010_4104358_+	hypothetical protein	NA	NA	NA	NA
AVJ23598.1\|4105667_4106090_-	arsenate reductase (glutaredoxin)	A0A2H4J8T1	uncultured_Caudovirales_phage	7.4e-72	96.4
AVJ23599.1\|4106110_4106824_-	arsenical resistance protein ArsH	A0A2H4J5V6	uncultured_Caudovirales_phage	3.1e-131	98.7
AVJ23600.1\|4106870_4107341_-	low molecular weight phosphatase family protein	A0A2H4J8A6	uncultured_Caudovirales_phage	4.1e-79	97.4
AVJ23601.1\|4107357_4108641_-	arsenical efflux pump membrane protein ArsB	A0A2H4J144	uncultured_Caudovirales_phage	5.3e-230	99.5
AVJ23602.1\|4108665_4109022_-	transcriptional regulator	A0A2H4J145	uncultured_Caudovirales_phage	2.3e-58	98.2
AVJ23603.1\|4109018_4109441_-	low molecular weight phosphatase family protein	A0A2H4J437	uncultured_Caudovirales_phage	1.1e-72	96.4

DBSCAN-SWA_6

4482141 : 4546588

Pseudomonas_virus(50.0%)

capsid,plate,terminase,integrase,tRNA,head,portal,protease,tail

attL 4499359:4499387|attR 4555539:4555567

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVJ23924.1\|4482141_4482870_+\|tRNA	alanyl-tRNA editing protein	NA	NA	NA	NA
AVJ23925.1\|4483001_4484486_-	2-methylcitrate dehydratase	NA	NA	NA	NA
AVJ23926.1\|4484685_4485876_-	2-methylaconitate cis-trans isomerase PrpF	NA	NA	NA	NA
AVJ23927.1\|4485887_4488482_-	Fe/S-dependent 2-methylisocitrate dehydratase AcnD	NA	NA	NA	NA
AVJ23928.1\|4488665_4489793_-	2-methylcitrate synthase	NA	NA	NA	NA
AVJ23929.1\|4489835_4490729_-	methylisocitrate lyase	NA	NA	NA	NA
AVJ23930.1\|4490725_4491439_-	GntR family transcriptional regulator	NA	NA	NA	NA
AVJ23931.1\|4491709_4492234_+\|protease	ATP-dependent zinc protease	NA	NA	NA	NA
AVJ23932.1\|4492252_4493785_+	hypothetical protein	NA	NA	NA	NA
AVJ23933.1\|4493784_4494771_+	alpha-L-glutamate ligase-like protein	NA	NA	NA	NA
AVJ23934.1\|4494958_4496302_+	aminodeoxychorismate synthase, component I	S4VT78	Pandoravirus	8.5e-53	36.2
AVJ23935.1\|4496529_4496832_+	addiction module toxin RelE	A0A0P0ZE17	Stx2-converting_phage	7.0e-08	30.9
AVJ23936.1\|4496831_4497194_+	transcriptional regulator	A0A222YXG1	Escherichia_phage	4.3e-28	54.7
AVJ23937.1\|4497321_4497630_-	hypothetical protein	NA	NA	NA	NA
AVJ23938.1\|4497835_4498453_-	bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH	NA	NA	NA	NA
AVJ23939.1\|4498604_4499339_+	phosphoadenylyl-sulfate reductase	NA	NA	NA	NA
4499359:4499387	attL	NA	NA	NA	NA
AVJ23940.1\|4499756_4501286_+	nitrate reductase	NA	NA	NA	NA
AVJ23941.1\|4501299_4502028_+	Asp/Glu/hydantoin racemase	NA	NA	NA	NA
AVJ23942.1\|4502133_4503057_-	LysR family transcriptional regulator	NA	NA	NA	NA
AVJ23943.1\|4503164_4503911_+	3-oxoacyl-ACP reductase FabG	NA	NA	NA	NA
AVJ23944.1\|4504038_4504725_-	HAD family hydrolase	NA	NA	NA	NA
AVJ23945.1\|4504949_4505261_+	cytotoxic translational repressor of toxin-antitoxin stability system	A0A1S5NR91	Burkholderia_phage	1.2e-23	64.3
AVJ23946.1\|4505184_4505511_+	XRE family transcriptional regulator	A0A1S5NNJ5	Burkholderia_phage	1.5e-27	62.5
AVJ23947.1\|4505562_4505928_+	DUF2784 domain-containing protein	NA	NA	NA	NA
AVJ23948.1\|4506171_4506507_+	hypothetical protein	NA	NA	NA	NA
AVJ23949.1\|4506576_4507617_+	EamA family transporter	NA	NA	NA	NA
AVJ23950.1\|4507944_4508214_+	short-chain dehydrogenase	NA	NA	NA	NA
AVJ23951.1\|4508773_4509022_+	hypothetical protein	NA	NA	NA	NA
AVJ23952.1\|4509033_4509285_+	hypothetical protein	NA	NA	NA	NA
AVJ23953.1\|4510636_4511431_-	restriction endonuclease subunit M	C7BGE1	Burkholderia_phage	2.2e-101	66.2
AVJ23954.1\|4511588_4512611_-\|portal	phage portal protein	A0A2H4J922	uncultured_Caudovirales_phage	3.6e-136	72.2
AVJ23955.1\|4512610_4514371_-\|terminase	terminase	Q9ZXM5	Pseudomonas_virus	2.9e-287	80.9
AVJ23956.1\|4514524_4515370_+\|capsid	phage capsid protein	A0A2H4J928	uncultured_Caudovirales_phage	2.5e-74	56.2
AVJ23957.1\|4515416_4516469_+\|capsid	phage major capsid protein, P2 family	A0A2H4JCR7	uncultured_Caudovirales_phage	1.9e-132	71.7
AVJ23958.1\|4516479_4517181_+\|terminase	terminase	A0A2H4J948	uncultured_Caudovirales_phage	2.8e-76	64.5
AVJ23959.1\|4517279_4517576_+	hypothetical protein	NA	NA	NA	NA
AVJ23960.1\|4517572_4518034_+\|head	head completion/stabilization protein	Q9ZXM1	Pseudomonas_virus	1.6e-51	63.4
AVJ23961.1\|4518033_4518246_+\|tail	phage tail protein	Q9ZXL9	Pseudomonas_virus	2.3e-21	72.7
AVJ23962.1\|4518273_4518627_+	hypothetical protein	Q9ZXL8	Pseudomonas_virus	2.9e-29	58.1
AVJ23963.1\|4518628_4518907_+	hypothetical protein	Q9ZXL7	Pseudomonas_virus	9.3e-23	68.6
AVJ23964.1\|4518903_4519749_+	peptidoglycan-binding protein	Q9ZXL6	Pseudomonas_virus	2.6e-100	69.7
AVJ23965.1\|4519745_4519949_+	hypothetical protein	NA	NA	NA	NA
AVJ23966.1\|4519945_4520389_+	peptidase	Q9ZXL5	Pseudomonas_virus	7.4e-30	52.9
AVJ23967.1\|4520485_4520968_+\|tail	phage tail protein	Q9ZXL3	Pseudomonas_virus	1.2e-46	68.4
AVJ23968.1\|4520957_4521416_+	phage virion morphogenesis protein	Q9ZXL2	Pseudomonas_virus	3.2e-52	67.3
AVJ23969.1\|4521477_4522050_+\|plate	baseplate assembly protein	Q9ZXL0	Pseudomonas_virus	9.5e-54	65.8
AVJ23970.1\|4522046_4522391_+\|plate	baseplate assembly protein	Q9ZXK9	Pseudomonas_virus	2.2e-37	68.1
AVJ23971.1\|4522387_4523299_+\|plate	baseplate assembly protein	Q9ZXK8	Pseudomonas_virus	4.2e-120	73.1
AVJ23972.1\|4523298_4523913_+\|tail	phage tail protein I	A0A2H4JAU2	uncultured_Caudovirales_phage	1.1e-76	68.7
AVJ23973.1\|4526211_4526769_+	hypothetical protein	R9TPW8	Vibrio_phage	5.5e-06	38.7
AVJ23974.1\|4526869_4528045_+\|tail	phage tail protein	Q9ZXK4	Pseudomonas_virus	1.6e-169	74.7
AVJ23975.1\|4528102_4528618_+\|tail	phage major tail tube protein	Q9ZXK3	Pseudomonas_virus	1.1e-72	77.1
AVJ23976.1\|4528667_4529003_+\|tail	phage tail protein	Q9ZXK2	Pseudomonas_virus	1.9e-22	56.8
AVJ23977.1\|4529011_4529131_+\|tail	GpE family phage tail protein	Q9ZXK1	Pseudomonas_virus	5.0e-10	76.9
AVJ23978.1\|4529120_4532102_+\|tail	phage tail tape measure protein	E5FFG5	Burkholderia_phage	2.9e-122	32.3
AVJ23979.1\|4532107_4532548_+	oxidoreductase	Q9ZXJ9	Pseudomonas_virus	5.9e-56	72.6
AVJ23980.1\|4532544_4533816_+	late control protein	Q9ZXJ8	Pseudomonas_virus	2.6e-192	81.1
AVJ23981.1\|4534147_4534942_-	zinc ribbon domain-containing protein	NA	NA	NA	NA
AVJ23982.1\|4535026_4535374_-	transcriptional regulator	A0A2H4JFL3	uncultured_Caudovirales_phage	2.1e-19	44.8
AVJ23983.1\|4535458_4535671_+	DNA-binding protein	A0A2H4JE67	uncultured_Caudovirales_phage	2.2e-08	46.8
AVJ23984.1\|4535700_4536174_+	hypothetical protein	A0A2H4JG61	uncultured_Caudovirales_phage	1.0e-53	64.7
AVJ23985.1\|4536170_4536467_+	transcriptional regulator	Q9ZXJ1	Pseudomonas_virus	1.1e-34	71.3
AVJ23986.1\|4536466_4536838_+	hypothetical protein	A0A2H4J947	uncultured_Caudovirales_phage	3.0e-16	46.1
AVJ23987.1\|4536913_4537147_+	hypothetical protein	NA	NA	NA	NA
AVJ23988.1\|4537153_4539877_+	bifunctional DNA primase/helicase	A0A2H4J936	uncultured_Caudovirales_phage	3.2e-269	51.4
AVJ23989.1\|4539902_4540721_+	hypothetical protein	A0A077K8T2	Ralstonia_phage	2.3e-24	33.9
AVJ23990.1\|4540746_4541094_+	hypothetical protein	Q9ZXI7	Pseudomonas_virus	7.5e-30	57.3
AVJ23991.1\|4541090_4541297_+	hypothetical protein	NA	NA	NA	NA
AVJ23992.1\|4541355_4541823_+	single-stranded DNA-binding protein	NA	NA	NA	NA
AVJ23993.1\|4541815_4543810_+	DNA methyltransferase	A0A0U1T6D1	Pseudomonas_phage	4.7e-209	70.7
AVJ23994.1\|4543802_4544429_+	hypothetical protein	Q5QF31	Pseudomonas_virus	2.2e-64	61.7
AVJ23995.1\|4544425_4544677_+	hypothetical protein	NA	NA	NA	NA
AVJ23996.1\|4544689_4545094_+	hypothetical protein	NA	NA	NA	NA
AVJ23997.1\|4545090_4545300_+	hypothetical protein	NA	NA	NA	NA
AVJ23998.1\|4545394_4546588_+\|integrase	site-specific integrase	A0A2H4JGM5	uncultured_Caudovirales_phage	1.2e-135	59.4
4555539:4555567	attR	NA	NA	NA	NA

DBSCAN-SWA_7

5755883 : 5768027

Mannheimia_phage(28.57%)

bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVJ25032.1\|5755883_5756120_-	hypothetical protein	B5TK57	Pseudomonas_phage	4.1e-11	56.1
AVJ25033.1\|5756497_5756776_+	Killer protein	A0A0M3LQB1	Mannheimia_phage	5.5e-15	39.1
AVJ25034.1\|5756790_5757078_+	addiction module antidote protein, HigA family	A0A0M3LPV0	Mannheimia_phage	8.4e-19	51.7
AVJ25035.1\|5757565_5757985_-	hypothetical protein	NA	NA	NA	NA
AVJ25036.1\|5757962_5758346_-\|bacteriocin	bacteriocin	NA	NA	NA	NA
AVJ25037.1\|5758634_5759090_-	chemotaxis protein	NA	NA	NA	NA
AVJ25038.1\|5759082_5764902_-	hybrid sensor histidine kinase/response regulator	W8CYM9	Bacillus_phage	2.8e-12	35.9
AVJ25039.1\|5765077_5767129_-	chemotaxis protein	A0A2H4J162	uncultured_Caudovirales_phage	9.3e-19	40.3
AVJ25040.1\|5767125_5767650_-	chemotaxis protein CheW	Q56AR1	Bacillus_thuringiensis_phage	5.1e-06	35.1
AVJ25041.1\|5767661_5768027_-	response regulator	W8CYM9	Bacillus_phage	1.1e-12	33.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP023269

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection