CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP023270	Achromobacter spanius strain MYb73 chromosome, complete genome	4 crisprs	DEDDh,DinG,csa3,WYL	1	0	3	1

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP023270_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023270_1

657596-657690

Orphan

Consensus_repeat	Method
GGGTGTCAGACACCGGCGGATTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023270_1

>merge|CP023270|1|657596-657690|CRISPRCasFinder
GGGTGTCAGACACCGGCGGATTTGTAAGACTGATTCGGGTGTCAGACACCGGCGGATTTGTAGGACTGATTCGGGTGTCAGACACCGGTGGATTT

>CP023270|1|1|657596-657690|CRISPRCasFinder
GGGTGTCAGACACCGGCGGATTT	GTAAGACTGATTCGGGTGTCAGACACCGGCGGATTTGTAGGACTGATTC
GGGTGTCAGACACCGGTGGATTT

Protein	Signature genes	Signature genes Name	Protein_function
CP023270.1\|AVJ26153.1\|650740_652519_-\|spermidine/putrescine-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224099
CP023270.1\|AVJ26154.1\|652656_653754_-\|iron-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224753
CP023270.1\|AVJ26164.1\|665432_666362_+\|50S-ribosomal-protein-L11-methyltransferase	unknown	unknown	gnl\|CDD\|283886
CP023270.1\|AVJ26163.1\|663975_665322_+\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|236307
CP023270.1\|AVJ26155.1\|653907_656415_-\|HAMP-domain-containing-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
CP023270.1\|AVJ26161.1\|662987_663422_+\|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|235443
CP023270.1\|AVJ26159.1\|660896_662267_-\|UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl--meso-diaminopimelate-ligase	unknown	unknown	gnl\|CDD\|130153
CP023270.1\|AVJ26152.1\|649659_650748_-\|lipase	unknown	unknown	gnl\|CDD\|226361
CP023270.1\|AVJ26160.1\|662364_662898_+\|thioredoxin	unknown	unknown	gnl\|CDD\|239264
CP023270.1\|AVJ26165.1\|666386_667712_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378759
CP023270.1\|AVJ26150.1\|647078_647813_-\|monofunctional-biosynthetic-peptidoglycan-transglycosylase	unknown	unknown	gnl\|CDD\|234603
CP023270.1\|AVJ26158.1\|660248_660848_-\|esterase	unknown	unknown	gnl\|CDD\|225692
CP023270.1\|AVJ30841.1\|648678_649578_-\|energy-transducer-TonB	unknown	unknown	gnl\|CDD\|367555
CP023270.1\|AVJ26148.1\|644976_645810_-\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	unknown	unknown	gnl\|CDD\|234673
CP023270.1\|AVJ26149.1\|645806_646985_-\|LPS-export-ABC-transporter-permease-LptG	unknown	unknown	gnl\|CDD\|275201
CP023270.1\|AVJ26162.1\|663510_663966_+\|acetyl-CoA-carboxylase,-biotin-carboxyl-carrier-protein	unknown	unknown	gnl\|CDD\|235777
CP023270.1\|AVJ26166.1\|667724_668666_+\|carbohydrate-kinase-family-protein	unknown	unknown	gnl\|CDD\|238917
CP023270.1\|AVJ26151.1\|647818_648682_-\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|234703
CP023270.1\|AVJ26157.1\|658271_660173_-\|ribonuclease-II	unknown	unknown	gnl\|CDD\|214935
CP023270.1\|AVJ26156.1\|656401_657073_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|223816

Protein	Function_ID	Function_description	E-value
CP023270.1\|AVJ26153.1\|650740_652519_-\|spermidine/putrescine-ABC-transporter-permease	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	4.91486e-102
CP023270.1\|AVJ26154.1\|652656_653754_-\|iron-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224753	COG1840, AfuA, ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism].	1.57655e-48
CP023270.1\|AVJ26164.1\|665432_666362_+\|50S-ribosomal-protein-L11-methyltransferase	gnl\|CDD\|283886	pfam06325, PrmA, Ribosomal protein L11 methyltransferase (PrmA). This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.	2.24313e-105
CP023270.1\|AVJ26163.1\|663975_665322_+\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|236307	PRK08591, PRK08591, acetyl-CoA carboxylase biotin carboxylase subunit; Validated.	0
CP023270.1\|AVJ26155.1\|653907_656415_-\|HAMP-domain-containing-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	3.79467e-43
CP023270.1\|AVJ26161.1\|662987_663422_+\|type-II-3-dehydroquinate-dehydratase	gnl\|CDD\|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	3.16948e-89
CP023270.1\|AVJ26159.1\|660896_662267_-\|UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl--meso-diaminopimelate-ligase	gnl\|CDD\|130153	TIGR01081, mpl, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase. Alternate name: murein tripeptide ligase [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
CP023270.1\|AVJ26152.1\|649659_650748_-\|lipase	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	1.11392e-136
CP023270.1\|AVJ26160.1\|662364_662898_+\|thioredoxin	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.20919e-34
CP023270.1\|AVJ26165.1\|666386_667712_+\|hypothetical-protein	gnl\|CDD\|378759	pfam11906, DUF3426, Protein of unknown function (DUF3426). This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 262 to 463 amino acids in length.	4.86387e-39
CP023270.1\|AVJ26150.1\|647078_647813_-\|monofunctional-biosynthetic-peptidoglycan-transglycosylase	gnl\|CDD\|234603	PRK00056, mtgA, monofunctional biosynthetic peptidoglycan transglycosylase; Provisional.	1.10467e-115
CP023270.1\|AVJ26158.1\|660248_660848_-\|esterase	gnl\|CDD\|225692	COG3150, COG3150, Predicted esterase [General function prediction only].	6.98706e-55
CP023270.1\|AVJ30841.1\|648678_649578_-\|energy-transducer-TonB	gnl\|CDD\|367555	pfam03544, TonB_C, Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.	1.34798e-10
CP023270.1\|AVJ26148.1\|644976_645810_-\|symmetrical-bis(5'-nucleosyl)-tetraphosphatase	gnl\|CDD\|234673	PRK00166, apaH, symmetrical bis(5'-nucleosyl)-tetraphosphatase.	2.7349e-154
CP023270.1\|AVJ26149.1\|645806_646985_-\|LPS-export-ABC-transporter-permease-LptG	gnl\|CDD\|275201	TIGR04408, LptG_lptG, LPS export ABC transporter permease LptG. Members of this family are LptG, one of homologous, two tandem-encoded permease genes of an export ATP transporter for lipopolysaccharide (LPS) assembly in most Gram-negative bacteria. The other permease subunit is LptF (TIGR04407). [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other].	1.6991e-88
CP023270.1\|AVJ26162.1\|663510_663966_+\|acetyl-CoA-carboxylase,-biotin-carboxyl-carrier-protein	gnl\|CDD\|235777	PRK06302, PRK06302, acetyl-CoA carboxylase biotin carboxyl carrier protein.	5.19771e-77
CP023270.1\|AVJ26166.1\|667724_668666_+\|carbohydrate-kinase-family-protein	gnl\|CDD\|238917	cd01942, ribokinase_group_A, Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.	1.39533e-101
CP023270.1\|AVJ26151.1\|647818_648682_-\|shikimate-dehydrogenase	gnl\|CDD\|234703	PRK00258, aroE, shikimate 5-dehydrogenase; Reviewed.	5.13172e-116
CP023270.1\|AVJ26157.1\|658271_660173_-\|ribonuclease-II	gnl\|CDD\|214935	smart00955, RNB, This domain is the catalytic domain of ribonuclease II.	9.1849e-54
CP023270.1\|AVJ26156.1\|656401_657073_-\|DNA-binding-response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	3.11313e-71

>CP023270.1|AVJ26156.1|656401_657073_-|DNA-binding-response-regulator
MRILLVEDNLDLGDAVESKLRSAGHSVQWVHDGVQASRWALDETWDALVLDINLPGKDGFTLIRELRAAGLDAPVLVMTARAEIEDKIDMLDLGADDYLVKPFDLRELEARLRALLRRPAGQTTSVAQYGNLSLDLANRHVELAGAPLELGRREFRLLEILVGKLGQTVAKERLMNQIFDLDDGSLNALELLISRLRKKLAGASVDIVTVRGVGYQARSHENP
>CP023270.1|AVJ26155.1|653907_656415_-|HAMP-domain-containing-histidine-kinase
MKIPESFSIRQRVFTLGAVLLACALIGLVFFLRGYAQRAAEQAFDRLLAASALTIAGSVQIEDNEVTVEPPVSSLAMLSGGERVFYEARTSNGRLITGYGDLAPGLPLAQSATPVFTYLRYHDEPIRIATVGRLVSASQHAGWVTLRVAETLGSREALAGEILQRSVLPLLAVSLVALGLLWFGVQRAFAPLAVVERELRRRAPDDLEPLSKPVPREVRRLIEALNGFMQRLSGAMDSLNTLVADAAHQVRTPLASLRAQAEVALDETDPQRLHARLERIHLNATHASQLINQLLMDATITHRMGKGARALVGVAETVNETRRRIGPVDAQRLRIAIAPEVRRARIAGDRVALREMLRNLVDNALRYAPDGPVEIQAMPVAGYRVALTVSDRGPGVADDEKESVQQRFSRGRAGESLPGSGLGLAIVRSVAVAHGGSLWLLDRPGGGLTARVVLPLARAGAGRALTTAAAALCAACLLLAAPSADVRAAGADARSAPIPEIVTRYPAPQPSSRVLTIAGPTDTPVVAPLIQGFQSHRPDVSVVYREMGSRELYEAAIEGRLQDVDVLMSSASDLQIRLANDGYAQSYASPYAARLPSWAIWRHEVYGFTFEPAVIVYNPKRFAEAAVPRSRQDLLRLLEQDPLRLRGRIGTYDIAASSLGYLLAEQDELVSSNFWGLANAMGQAGVRLAATSAEILDAIERDELDIGYNILGSYALSRQAAGRPIGVVFPQDYVLVLARSVLIARTAPNPDLGRALVDWLLSPAGQQVASSHAALGSIMEDTPGRWTSEAVLARSQGIVQPVVLSPALLVGLDQRRHSRFVQNWIRLVTDTPQRP
>CP023270.1|AVJ26154.1|652656_653754_-|iron-ABC-transporter-substrate-binding-protein
MLAKSKLTAVCAAAFAIATGSAFAQAVPAGYPADYQKILDGAKKEGKVVIYSTTDTKAAGPIIKGFEALYPGVKVEYNDMNSTELYNRYISEQAAGGGSGDIVWSSSMDSALKLATDYALKYQSPEAGKLPAWANWKDSTYGTTYEPAVFIYNKRLIPANEVPTTHGALAKLIASQPDKFKNKVTTYDIEKSAVGFMLAVQDKANDPKYFETLKDIAKGGLIVQSSTGTMMERVSSGENLIGYNILGSYAETRAKNDPSLGVAYPTDYALVLSRVAFISKKAKNRNAAKLWMDYLLSQKGQEIMANQADLASVRDDIEGDNDVDGMTKKLGASLKPIPVNETLLDYLEQNKRLEFIKQWRAAAGK
>CP023270.1|AVJ26153.1|650740_652519_-|spermidine/putrescine-ABC-transporter-permease
MQSLRRKWQSLPRGVVVLITALAIYVPLSFIIIQSFLSAPFFSPSKAWSLDAFRFIFADPDFYKALRSGFILAFGLAAIAIPLGGMLAFLMIRTDLPGRRWIEPLILVPVFVSPMVLGFGYVVAAGPVGFFSTWVQNILGFVPWNVYSLTSIVIIAGLTHVPHAYLYISSALRSMGSDVEEAARVAGASPLRVMVSVSLPMVRPAMLYATVLLFFLGLEVFGLVLVLGDPEGNLVLATYLYKLTNKLGIPSYHLMAAVAVVLICMTIPLVMLQRRLMRTANRFVTVKGKASRARPLPLGKWRWVAGAVVAFWLFVTIIVPLTGVLLRAFVSNWGLGVSLFDVLSLDAFRTVFAQPNLMRAIVNSVAIGVFGGALAVMCYMFVGLAMHRKPDNVTRFMDYSVLVPRAVPGLLAGLAFLWVFLFVPMWLDNALDVDENGWLSALPFAEWLRENFVEWLRALRSTIFSVWLAYTVVWMAYGLRLISSTLLQVGPELEEAARTAGARRGQVTRHVTVPLAKYGLIGSWLLMFLIFEREYSTGVYLLSPGTETIGSMLVSLWASGAIDIVAALSFINIVLVVIGLGIALRFGVKLHD
>CP023270.1|AVJ26152.1|649659_650748_-|lipase
MIELSVEDLHLDYGDNPVLKGVSMQLRQGEVVSLLGPSGSGKTTLLRAVAGLEGPKRGRITIGENVVYDGAARAEIPAEERNLGLVFQSYALWPHKTVYENVAYPLKLRKTPGAEVRERVQAVLDQLGLGKLGQRHPHALSGGQQQRVAIGRALVYSPPVILLDEPLSNLDAKLREEARAFLRELIIRLGLSALMVTHDQSEAMAISDRILLLNNGKIEQQGTPQEMYGSPSTLFTAEFMGSNNRLDGKVTELRDGQARIEGAGWSLWGKAGAGVAAGQDATAVIRVEQVRLADDPDGNHVDMPLLTSMYLGDRWEYLFRTPDADPARSLALRAYGPEGREPGPCRLALPANKVWIFPRASA
>CP023270.1|AVJ30841.1|648678_649578_-|energy-transducer-TonB
MVQRADSPSVLSRYLWWLGAPAQHYLRIGIAISLLVHAGALAWRFSAPTQTRPPVTSLEVVLLNARSETPPENPRTVAQNQMTGGGNADRGVSTTPLPQTGSSAETIVLEAMRQRQVQLEAEQARLMTQLRSPHNAGPERQAVNPWPDGADVGQDAQDQASVIQNAQVAALAARVQQYSAEPRKQFIAPSAEASRYAGYLDAWRTRIETVGTQHYPDEARGRIYGSLRITVSVRADGSIAEVEIDQPSPHAVLNQAARRIVQLAAPFPPFPPDIARDTDVLVITRTWHFVNDTLETQAP
>CP023270.1|AVJ26151.1|647818_648682_-|shikimate-dehydrogenase
MTEAIPQARYAVIGNPIAHSRSPQIHAMFSQQTGKPLRYERLLAPVDGFADAVAAFVADGGLGLNVTVPFKLDAYALASGRLSNRARLAGAVNTLSWRDGVWHGCNTDGVGLVNDLLRLGVRLPGAAVLLVGAGGAARGVLQPLAEAGCSRIHIVNRTAARAEELAAAWGTSGVSPQTQVTAGGLATAAIPGGWNLVINATASGLQNAAPDLPPGLYADGAAAYDMMYGAQPTAFMRQADADGAALTADGLGMLVGQAAESFFIWHGVRPDAAPVLTALREALAAGS
>CP023270.1|AVJ26150.1|647078_647813_-|monofunctional-biosynthetic-peptidoglycan-transglycosylase
MATRTGRSGGRNWFRITTGLVMALVCAILLYQFWLFAQVVWYNYRDPGSSAMMREELSRLRKDDPAIELKYEWVAYDKINRSLKRAVIASEDSNFTGHDGVEWDAIRKAWEYNQKQEEAGRSKMRGGSTITQQLAKNLFLSGSRSYLRKGQELVLAYMIEHVMSKERILELYLNVAEWGVGVFGAQAAAKHYFNTTAANLGNSQSARLAAMLPNPRFYDSHRKSNYLNSRVGVLTRRMQMVDIP
>CP023270.1|AVJ26149.1|645806_646985_-|LPS-export-ABC-transporter-permease-LptG
MRTARRYLAREVYRSCAVVLLALLGLFTFFALVDDLDNVGDKFSMMALLYMQALAVPTRLYDLLPIGLLIGAILALAGLAQRNELVILRVSGVSGMKLLRMLWIVTIPLMIGAGLLSEYVTPWAEVKTGEANLMFRGKAGGDRLKSGYWFKEPTANGGTRIINIAELKGDGQVAGVTLYEFKKDLTLSALSTAPTGTFTRGDLVLKDVSETRLDAEAAEALANARPPKNPPATVVKLPERSIDTTLSAERLLARVLTPERMSIVTLLDYVEYLRDNQLQYGRQVVALWRKLAYPFTLLVMITIAAPIGLMQTRRGGVGAKVFVGILLGVGFFMLNQLALNVGMLGKWPPWLTALGPNLGAMALALGAMSYMEYRHTITRLVQQRWPWSKSPA
>CP023270.1|AVJ26148.1|644976_645810_-|symmetrical-bis(5'-nucleosyl)-tetraphosphatase
MNGSIWMIGDVQGCCSPLDRLLSHPDLVGDPKSRFWFAGDLVNRGPQSLETLRRIIDLGDRATVVLGNHDLHLLAAAAGVRKPSKSDTLESILRAPDATDLLNWLRFRPLAHFEQNHLLVHAGTLAKWDVAKTLALAGEVQDALRGPNWQKALQKMYGNEPATWKEDHKGGKRMRVIINALTRIRLCTPNGHMEFATKVTPGAWPPGLVPWFDVPNRATRNVTTVFGHWSTLGLLQRPDVICLDTGCVWGGSLTALRLQDRKLVQVKCSQFQDPMAE
>CP023270.1|AVJ26157.1|658271_660173_-|ribonuclease-II
MYVFYEDDGSFKAGNILSETDASLQVESESGKRSKIKRANTLFNFASPDPAALMTQAAATAETLDLQFLWECAPQEEFDSPALAADYFGHAPTPVEQAALLMRLHGAPAYFHRRGKGRYRPAPPDILAAALAALEKKQRQAEQQQEWVDEMAAGRLPEPIAQAAESLLIRPDKNSQQWKALDAACAKLGKTPDRLLLELGAWPHALALHKRRFLAVNFPRGLAFPDVELPPIDRELPLADAEIYSVDDVTTTEIDDALSVSTLPDGRVRVGVHVAAPGLSVTRDSELDKLARARLSTVYMPGDKIPMQPDSVIQAFSLDAGREVPALSLYVIANPETGEIIESETRLERIVVRENLRHNMLDSQVTEASLSDPDADLPYGHWLRPLWKLAQALSAQRENVRGKPENNSRVEYSFYLDGNPDDPDTPVRLVPRQRNAPLDRMVAEYMILANNLWGGLLNQHGVPGIYRSQQAGRVRMSTQALPHEAIGVPQYAWSTSPLRRYVDLVNQWQLIAAVEHGVSARLIAPFKPRDADLFAIIGAFDAQYAAWAEFQSAMERYWCLRWLKQNGVTRTVAHVLRDDLVRFANAPLVTRVGGMPEFERGTAVEVDILGMDELSLELDCRFVGEVKGEAAAS
>CP023270.1|AVJ26158.1|660248_660848_-|esterase
MILYLHGFRSSPDSFKARMMADAMAARGLTDAWACPQLPASPREAIDLALGMARDRLADTDSPRELTVIGSSLGGFYATWIAEQLGCKAVLLNPAVHAARDLATQVGEHHMYHSGAPFVFLPEYVDELAAIHAPRITQPDRYFLVAATGDEVLDWREMRDRYAGCRQRIVQGSDHGLSDFAQWMPEVLEFALGGKPVRA
>CP023270.1|AVJ26159.1|660896_662267_-|UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl--meso-diaminopimelate-ligase
MHLHILGICGTFMGGLALIARAAGHKVTGCDAGVYPPMSTQLSEQGIELIEGFGAEQLALKPDLYVIGNVVSRGNPLMEAILESGARYVSGPQWLGDNILPGAHVLAVAGTHGKTTTSSMLAWVLEAAGMAPNFLIGGVAQDLHVSARYDPARRPFVIEADEYDTAFFDKRSKFVHYRPRTAILNNLEYDHADIFPDLAAIETQFHHLVRTIPGSGRIVRPTQSDALDRVIARGCWSDTVTFGPDGQWQASPPDADGAFEVTRAGVRAGTVRWSLSGEHNRMNALAALAAAEHVGVPAEQGIDALTRFAGVKRRMELRGTVNGIKVFDDFAHHPTAIATTVEGLRRQVGAARILAVLEPRSNTMKLGTMAARLPEALTDADLVFCFGASEGKHALGWNPAEVLAPLGGRASSYDDIGALVDAVAGAARPGDQVLVMSNGGFGGIHGKLLDALQARG
>CP023270.1|AVJ26160.1|662364_662898_+|thioredoxin
MNRRLLLSAAVAVAATVAGGYTLMGRKPKNDAAPADAGDPVAGLMQMQLPDLNGASQSLAGWKGQPIVVNFWATWCAPCVKEMPALDALQKKYPQVRFVGIGVDSAANMQKFVEKVQVSYPLWVIGAGAIDTLRKLGSPSGGLPFTIVFNADGSINRKILGEVQPDDLDRTLAGLKA
>CP023270.1|AVJ26161.1|662987_663422_+|type-II-3-dehydroquinate-dehydratase
MAQNILVLHGPNLNLLGTREPHIYGSLTLAQINERLELLAGELGATLSAWQSNHEGALVDRIQAARQDGTDFIIINAAAYTHTSVAIRDALAGVAIPFIEVHLSNLYKREPFRHHSYLSDLAQGLISGLGADGYEAALRYAVRH
>CP023270.1|AVJ26162.1|663510_663966_+|acetyl-CoA-carboxylase,-biotin-carboxyl-carrier-protein
MDLRKLKTLIDLVAESGIAELEITEGEGKVRIVKFSQTLQPVAYHQPEAGVPAAPVAAAAPAAAPAAPAAPVIQGHVVKAPMVGTFYRSPNPGAAPFIDVGATVKEGDPLCIIEAMKLLNEIEADKSGVIKEILVENGEPVEYGQPLFVIG
>CP023270.1|AVJ26163.1|663975_665322_+|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MFEKILIANRGEIALRIQRACRELGIKTVVVHSEADREAKYVRLADESVCIGPAPSRESYLNMPAIISAAEVTDSEAIHPGYGFLSENADFADRVEKSGFVFIGPRPDTIRLMGDKVSAKRAMIEAGVPVVPGSEGALPDDPQEILRTAREVGYPVIIKAAGGGGGRGMRVVYTEAALLNAVTMTRSEAGAAFNNPEVYMEKFLENPRHIEIQVLADGGRNAVWLGERDCSMQRRHQKVIEEAPAPGVARRLIERIGDRCADACRKMGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTELITGIDLVQQQILVAAGEKFTLRQRDITFKGHAIECRINAEDPFRFVPSPGRITNWHTPGGPGVRIDSHAFNGYFVPPNYDSMIAKVITYGDTRDQALARMRIALSEMVVEGISTNIPLHREMLQDARFIEGGTSIHYLEHKLAQRP
>CP023270.1|AVJ26164.1|665432_666362_+|50S-ribosomal-protein-L11-methyltransferase
MRELVLHCSEAQAEALSDALLEAGVLSVSVEDADFGTEVERPLFGEPGTEPDVQAWDRNLVVALLPDGADPAQIMAEAGQTAELDASVFDGWSLRDVPDADWVRLTQSQFGPIHIAERLWIVPSWHRDNPDVPGLDTAVPDQDGAIHIELDPGLAFGTGSHPTTHLCLAWLEAELPAGATLLDYGCGSGILAIAARKLGAGPTQAVDIDAQAVQSTVFNAQVNKVELQAMLPDGLADGTFEVVVANILSNPLKVLAPMLAGRVASGGHLVLSGVLERQAEEVAAAYAPWLPMSVWRARDGWVCLHGKKP
>CP023270.1|AVJ26165.1|666386_667712_+|hypothetical-protein
MALTTRCPQCGTSFKVVPDQLRVRNGLVRCGACSTVFDGRACLVSASGAPVAAAVPATAPLPSSVAAIAAPVLSAPEPHPPAAPIPEPAFTPVPRSPAAPAEPRVVLPWEDEPVAPPAPTIPPAVLRGRDDIRKRAEPEAAMPDDHAEDDDYPDDDGEPFLREPEPPRTAPAQRPPVFRNEPIVASRSGEPTLDWRAGQPRSDLRSDVRHDPRHDISDDLHDDVRDIERDDEYEDEDDLERGAHEPVLGDTRTRYSSATDVGRAPPEFLDQDRIERSGFVRKLWGYACVAGLIVLALQLLYAYRTEIANSVPALRPVLEAACKPLDCTVGYARRRDLISISSSSLQPPTGAAAIDDGRTRLVLTVMLHNRYDKPQHWPALVLELNDLSDTVVVRKVLMPENYLTPEQLRGPFGSQGALKISVPIEVTGVQVNGYQLDKFFP
>CP023270.1|AVJ26166.1|667724_668666_+|carbohydrate-kinase-family-protein
MATPVLVCGSMAFDTIAVFEGRFKEHILADRIQSLSVSFLVPSMRKEYGGCSGNIAYNMNLLGGTPVPVATIGEDAGEYMQRLSGLGIDVSRVKVIPDTFTAQCFITTDLDDNQITAFHPGAMSFAAQNDLSDADAAWAIVAPDAKEGMFAHAERLHKRGIPFIFDLGQAMPLFDGADLERMLKLAQALTVNDYEAGVVEQRTGRSVADIARTLQAVVVTRGAEGATLHTEGKTIQIEPVRASQVVDPTGCGDAQRGGLLYGLTSGWSWEDSCRLGNVMGAIKIASRGPQNHVPTRAEIDAVLHATYGIHLPA

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Crispr_ID: CP023270_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023270_2

2347841-2347935

Orphan

Consensus_repeat	Method
TTTGTAGGACTAAATGAGGTGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023270_2

>merge|CP023270|2|2347841-2347935|CRISPRCasFinder
TTTGTAGGACTAAATGAGGTGTCAGACACCCGTGGTTTTGTAGGACTAAATGAGGTGTCTGACACCCATGGTTTTGTAGGACCAAATGAGGTGTC

>CP023270|2|2|2347841-2347935|CRISPRCasFinder
TTTGTAGGACTAAATGAGGTGTC	AGACACCCGTGGTTTTGTAGGACTAAATGAGGTGTCTGACACCCATGGT
TTTGTAGGACCAAATGAGGTGTC

Protein	Signature genes	Signature genes Name	Protein_function
CP023270.1\|AVJ30960.1\|2356495_2357473_-\|taurine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270281
CP023270.1\|AVJ27497.1\|2344890_2345856_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|227311
CP023270.1\|AVJ27506.1\|2357697_2358885_+\|amino-acid-dehydrogenase	unknown	unknown	gnl\|CDD\|223737
CP023270.1\|AVJ27508.1\|2359500_2360250_+\|electron-transporter-RnfB	unknown	unknown	gnl\|CDD\|224997
CP023270.1\|AVJ27493.1\|2339435_2341040_-\|acyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|235722
CP023270.1\|AVJ27500.1\|2347169_2347802_+\|lysine-transporter-LysE	unknown	unknown	gnl\|CDD\|224199
CP023270.1\|AVJ27495.1\|2342187_2343180_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
CP023270.1\|AVJ27501.1\|2347971_2349858_-\|multidrug-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224055
CP023270.1\|AVJ27502.1\|2350223_2353832_-\|thiol-reductant-ABC-exporter-subunit-CydC	unknown	unknown	gnl\|CDD\|224055
CP023270.1\|AVJ27503.1\|2353925_2354861_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|182990
CP023270.1\|AVJ27507.1\|2358868_2359432_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377578
CP023270.1\|AVJ27491.1\|2337264_2338536_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|380550
CP023270.1\|AVJ27505.1\|2355706_2356477_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
CP023270.1\|AVJ27496.1\|2343176_2343899_+\|short-chain-dehydrogenase	unknown	unknown	gnl\|CDD\|181044
CP023270.1\|AVJ27499.1\|2346554_2347037_-\|AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
CP023270.1\|AVJ27504.1\|2354930_2355710_-\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|213260
CP023270.1\|AVJ27498.1\|2345868_2346543_+\|dimethylglycine-dehydrogenase	unknown	unknown	gnl\|CDD\|153233
CP023270.1\|AVJ27509.1\|2360249_2361182_+\|electron-transfer-flavoprotein-subunit-alpha	unknown	unknown	gnl\|CDD\|215032
CP023270.1\|AVJ27492.1\|2338677_2339421_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225099
CP023270.1\|AVJ27494.1\|2341043_2342084_-\|cyclase	unknown	unknown	gnl\|CDD\|377240

Protein	Function_ID	Function_description	E-value
CP023270.1\|AVJ30960.1\|2356495_2357473_-\|taurine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270281	cd13563, PBP2_SsuA_like_6, Putative substrate binding domain of sulfonate binding protein-like, a member of the type 2 periplasmic binding protein fold. This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.59492e-55
CP023270.1\|AVJ27497.1\|2344890_2345856_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	9.04918e-76
CP023270.1\|AVJ27506.1\|2357697_2358885_+\|amino-acid-dehydrogenase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	2.46454e-58
CP023270.1\|AVJ27508.1\|2359500_2360250_+\|electron-transporter-RnfB	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	6.03508e-90
CP023270.1\|AVJ27493.1\|2339435_2341040_-\|acyl-CoA-synthetase	gnl\|CDD\|235722	PRK06164, PRK06164, acyl-CoA synthetase; Validated.	0
CP023270.1\|AVJ27500.1\|2347169_2347802_+\|lysine-transporter-LysE	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	2.38739e-37
CP023270.1\|AVJ27495.1\|2342187_2343180_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	1.69286e-120
CP023270.1\|AVJ27501.1\|2347971_2349858_-\|multidrug-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	6.794e-158
CP023270.1\|AVJ27502.1\|2350223_2353832_-\|thiol-reductant-ABC-exporter-subunit-CydC	gnl\|CDD\|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	3.61612e-144
CP023270.1\|AVJ27503.1\|2353925_2354861_+\|transcriptional-regulator	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	9.57439e-64
CP023270.1\|AVJ27507.1\|2358868_2359432_+\|hypothetical-protein	gnl\|CDD\|377578	pfam05962, HutD, HutD. HutD from Pseudomonas fluorescens SBW25 is a component of the histidine uptake and utilisation operon. HutD is operonic with the well characterized repressor protein HutC. Genetic analysis using transcriptional fusions (lacZ) and deletion mutants shows that hutD is necessary to maintain fitness in environments replete with histidine. Evidence outlined by Zhang & Rainey (2007) suggests that HutD functions as a governor that sets an upper bound on the level of hut operon transcription. The mechanistic basis is unknown, but in silico molecular docking studies based on the crystal structure of PA5104 (HutD from Pseudomonas aeruginosa) show that urocanate (the first breakdown product of histidine) docks with the active site of HutD.	4.4744e-34
CP023270.1\|AVJ27491.1\|2337264_2338536_-\|ABC-transporter-permease	gnl\|CDD\|380550	cd06327, PBP1_SBP-like, periplasmic substrate-binding domain of active transport proteins (substrate binding proteins or SBPs). Periplasmic substrate-binding domain of active transport proteins found in gram-negative, gram-positive bacteria, and archaea. Members of this group are initial receptors in the process of active transport across cellular membrane, but their substrate specificities are not known in detail. However, they closely resemble the group of AmiC and active transport systems for short-chain amides and urea (FmdDEF), and thus are likely to exhibit a ligand-binding mode similar to that of the amide sensor protein AmiC from Pseudomonas aeruginosa. Moreover, this binding domain has high sequence identity to the family of hydrophobic amino acid transporters (HAAT), and thus it may also be involved in transport of amino acids.	0
CP023270.1\|AVJ27505.1\|2355706_2356477_-\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	8.83412e-75
CP023270.1\|AVJ27496.1\|2343176_2343899_+\|short-chain-dehydrogenase	gnl\|CDD\|181044	PRK07577, PRK07577, SDR family oxidoreductase.	1.2128e-69
CP023270.1\|AVJ27499.1\|2346554_2347037_-\|AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.48979e-51
CP023270.1\|AVJ27504.1\|2354930_2355710_-\|ATP-binding-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.75611e-122
CP023270.1\|AVJ27498.1\|2345868_2346543_+\|dimethylglycine-dehydrogenase	gnl\|CDD\|153233	cd03139, GATase1_PfpI_2, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	1.32022e-79
CP023270.1\|AVJ27509.1\|2360249_2361182_+\|electron-transfer-flavoprotein-subunit-alpha	gnl\|CDD\|215032	PLN00022, PLN00022, electron transfer flavoprotein subunit alpha; Provisional.	1.28808e-113
CP023270.1\|AVJ27492.1\|2338677_2339421_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	7.83346e-37
CP023270.1\|AVJ27494.1\|2341043_2342084_-\|cyclase	gnl\|CDD\|377240	pfam04199, Cyclase, Putative cyclase. Proteins in this family are thought to be cyclase enzymes. They are found in proteins involved in antibiotic synthesis. However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.	5.50017e-06

>CP023270.1|AVJ27500.1|2347169_2347802_+|lysine-transporter-LysE
MADMALFLGALLIVYVVPGPDMILLLETGLLRGRGQALAVAAGLAIARAAHVTLAALGLAALFKTHPWAFDAARTVGGCYLVWLGIRLLRAPLAIPPLDGEAAPRHAGWGPALMSGVLTNVLNPKALLFCSVLLPQFVSPERGPIGQQFAVLGVILVGLGLTFDVLCALAGGAVGRWMSASPRAQKIQALVFGTALIGFGLRLTFANRPA
>CP023270.1|AVJ27499.1|2346554_2347037_-|AsnC-family-transcriptional-regulator
MPKRQLDAYDRRILEALQKNGRLTNVELADQIGLSPSPCLRRVRMMEEAGVIQGYEARLDPHEVGLGLTVFVGVKVERHHERDAEMFRNEVSALPEVIAAHLVSGESDFLLQVVVPDLRGYEQFLLHTLLKLPGVKDIRSNFAIQTVKPQSPLPLDHLGR
>CP023270.1|AVJ27498.1|2345868_2346543_+|dimethylglycine-dehydrogenase
MQVNIVLFEGLTQLDMTGPYEVLANAPDFTVDFVAKTMEPVRCDRGLRFVPTQTIDSAPPCDLLVVPGGPGTDDAIVDPAWVDFTRRQGQGAKYLFGICTGSLLLGAAGLLRGKRASSHWRARELLARFGATPSDERLCVDGNVFTAGGVTSGIDMGLKVVASLCGEDVAKLIQLQIEYDPKPPFPGGTPKTSEPAIVERYLAMSQARFERRSAAVDRAAAAMP
>CP023270.1|AVJ27497.1|2344890_2345856_-|AraC-family-transcriptional-regulator
MKTPEPSIGEPAPRGAPERAPIAPQRLMFVLYDGFQPLDLAGPWQAFSSANEEAGRQLYAMNTIAASPVVSTWEQGLRMQVDGTFEDDGDASIDMLLVPGGPGVDRAAAHGETRAWLRRRDAGTRRTASVCTGAFVLAATGLLDGRAVTTHWRSADRLRQLYPALRVDDDRIFIESGKYWTSAGVTAGIDLALALIERDFGAALSQQVARRLVVFMRRNGDQRQYSQTLRLQDRVAAPFRELIEKMEARLSARWSVDDMADACRMSRRTFQRKFAAHFGVAPTEVLRRLREERAGALESVGKMTRKAVEHHVGPVHRRPRQ
>CP023270.1|AVJ27496.1|2343176_2343899_+|short-chain-dehydrogenase
MNPPIALVTGASRGIGRAIVARLIEDGFQVVNFSRTSPETLLPGETFRSVDLCDAAATVAAGRELAAQQPVLHLVNNAGMIQVANIEDITQEELARTMALNLTAPILLMQALLPGMRQAKYGRVVNIGSRAALGKGGRSVYGASKAGLAGMTRTWALELAGDGITVNTVAPGPVATELFNQSNPPGAPKTLALEAAIPVGRVGRPDEVAHTVAMFLDPRAGFVTGQVLYVCGGVSVGVVG
>CP023270.1|AVJ27495.1|2342187_2343180_+|ABC-transporter-substrate-binding-protein
MTQLPHPRAGWRFALAALAVLALPAVHAAGYPEHPVTVVVPYPPGGGADLFGRAIANALQPGLKQTVLVENKPGAGGNIGMAYVARAKADGYTLGLGTIGTQTINQFLYGNMPFDPERDLVPIALVSTTPNVIAVSAKSPYKTVADVIKAAKQSTDKKLTYASPGIGSSVHLTGAYFEAMAGVTMLHVPFKGTSASLPAVAGGQVDLLFDNLPGALAQIKDGNLVRGVAVTSAARDPSVPDLPTVAESGLPGFDVTAWFALYAPRNTPAPVVEQLINAARSGLATPAIAANFATMGAKPGTLFGKDLAAFESAERKKWGGLIKDQGIKAQ
>CP023270.1|AVJ27494.1|2341043_2342084_-|cyclase
MKRWTQRPEGSTWGDFGPDDELGRLNLLTEEKVLQAVREVRAGKVFCLSLPLDLPGGNVLNPRRHAPTLKPTFREGTPYLNFAMSQVQPEAIDVLSDDQVTLSMQYSTQWDGLCHVGAMFDIQGDGQARRVYYNGYAAGVDVFGGADPDNSETACCPPGGSYARKLSVSRYAEKGMQGRGVLVDLARAFGPGRTIVGHEQLQAAMREQDALPEPGDMLVLRTGFAEAVVAMNGQPDPHRLEQTGAVLDGADPALLDWITQSGIAAICADNYAVESYPARTSGPGHSILPLHHHCLFKLGVPLAELWYLKDLADWLHANSRSRFLLTAPPLRMPGAVGSPVTPIATV
>CP023270.1|AVJ27493.1|2339435_2341040_-|acyl-CoA-synthetase
MPLPYSTFSDHLDALAARKPEAIALIDRDQPLSFADLRTRSLALAAGLSRIGVQPGHRVAVWLPNCTAWVESFLACAHLGALVLAVNTRFRSVEVADILGRGRADWLVYWPDFKGIDFQGILDGVAPVDVDQLQGAVALAGPDELPPASLHGKPVHRYDALLACADPAPVAQANAGVLCFTTSGTTSKPKFVLHDQKTLLRHGAMVAQAFGYDDRACVLASAPFCGAFGFATLVSGLARGVPVVCAPVFDAAQSAQAIARHAVTHTYANNEALVGMMQAAAPGGFSSVQLFGFASFTPALDNMLDLARAASVPLTGLYGSSELIALVAGQPRDPADGDVSARHQPGGTLIYPTARVRARDPETGQVLPHGQSGEIEILSPSLMQGYLDNPDATRAAVTDDGYFKTGDLGYTLTDRQFVFQTRMGDSLRLSGFLVNPVEIEQVVETLPGVRACQVVGATRNGKIVPYAFVLLQEGAQADPAGWTAACKAAMAGFKAPAGFTVLDAFPSVESANSVKIQKHRLREMADAMLSTSES
>CP023270.1|AVJ27492.1|2338677_2339421_-|GntR-family-transcriptional-regulator
MPARKLFSRSPQPLYLQAAALFRSHIQNRTWRPGQQIPPLESLMETYGISRATIRQAFGLLEEDGLIRRSRGSGTFVNAELPETPTLLIPKTWAETVELSNQLGTVSLVESSADSPLPDTLGMPCGADRSGSFQYLRRIHTTDAGPFCYSEVFLDSGLFRKHRARIQKSTVAPVLDQFYGARISEARQVLNVIEAGQESAESLQIPVSSPVAELRRYACIDGRVVYFARLEFPFRKVRMEFDLLTSR
>CP023270.1|AVJ27491.1|2337264_2338536_-|ABC-transporter-permease
MRHADRTRISMQCRSTFVRLFATTAFTATALAATGAHAQAPAPAVSDDVVRLGLILDMSGVYADVTGKGSATAAEMAIADFGGTVLGKKVDLLVVDHQNKADIAAAKAREWYDVQKVDAIMDVAGSAPALAVLEVAREKKKIVVFSGPGTERITNDLCSPYSVHYTYDTWSLANTTARATVEQGGKSWYFLTADYAFGHTLQASATDVVKANGGTVLGASRHPLGSSDFASYLLQAQASKAQIVGLANAGGDTVNAIKAASEFGLTKGGQKMAGLLLYINDIHAIGLDAAAGLTLTEAFYWDMNDQTRAWSQRYYDKLKKMPNMSQAGTYSSVMHYLKAVQAAGTDEPTAVMKQMKATPINDFFATNGRIREDGRMVHDMYLFEVKNPSESKRPWDYYKLVATLPGDQAFMPLSRSTCPLVKK
>CP023270.1|AVJ27501.1|2347971_2349858_-|multidrug-ABC-transporter-ATP-binding-protein
MARKKIDLRGQAFKDVLGFTFRYWGRQPVRIVVIMALALLSAVADVLTPMYAGRLVDAVASGAAGDQLAWNAAITAFWLLVALGVGGTLLRQAVFQNIITFTLKMMNGIASNAFYRVQRFSTDWHANSFAGSTVRKITRGMWAVDLLNDTLVVALLPSVVMLVGATALLGAHWPLMGLVVGLGSVLYIAVTATLSLAYVAPAARLGNAWDTRMGGALADAVSCNAVVKAFGAETREEARLDRVIDKWRRRTRRTWIRATFNGGIQGAMLVAMQASILGASLLLWSRNQASVGDITFTLTMFFVLQGYLRDVGMHIRNLQRSVNDMEELVSLEKQPLGVEDRPGAGDIAVTAGEIRFEDVTFRYGAHNVALYDRFSVRIAPGERVGLVGHSGSGKTTFIKLIQRLYDVNGGRITIDGQDIAQVKQASLRGQIAIVQQEPVLFHRTLAENIAYARPGASQADIEQAARLASAHDFIMALPKGYETLVGERGVKLSGGERQRVAIARAFLADAPILILDEATSSLDSESEVLIQRAMDRLMEGRTTLVVAHRLSTVRALDRLLVMDHGRVIEEGSHDALIRLKGGLYRRLFERQALELTKGLDPAELLEDGAVPPPAKTDDVETASFAFGK
>CP023270.1|AVJ27502.1|2350223_2353832_-|thiol-reductant-ABC-exporter-subunit-CydC
MYFDSRLWRLTEGLRAGMAGGIFLGLLALAAGIARYVFLGQLLARVFDGAPWQEWATPALCVAAMVLLRALLDDWRTVQANRTSAAIQHTLRARLYDRIVALGPAWFASQRTGGVMLTVVDGVEQLQTFFGQYLPQVAIAAAAPFAIFAVIAFWDVPTALVFLAAALFALFGPMAVHMLDRRASLARSRSLNEFGEEFLDAVQGLPTLKSYGQGKAWGERLAARARALSDNTFWVLSVSLLTRGISDLGVALGAALALTLGALRVTAGDMSVEALLIVLMAGTEIFRPLRDLRAVLHRGMLGQSAAASIHALMDAQPLTPAPDTRAAQAGPARLAPTIEFDDVAFAYTPERAAHRGLAFRIAAGERVGVVGPSGAGKSTIVRLLLRECVPQSGAIRVGGHDVNALDTQFLLSHIALVSQDITLFHGTIDDNLRLGRPDATPDEVRAAARAANIDDFIMALPDGYATRIGERGLQLSGGQRQRVAIARALLRDAPILILDEALSSVDTENEALIQQALDRLMAGRTTLILAHRLASVIGADRILVLDQGRVAEAGPHADLMREQGLYYRLMHEQAAAHRNPAAGSPPAAQQAAGNTAAEPDDGNAPGPALRSLDADADHVGWRATLGTLLSVVRPWRGTLIATILLGVARVAAFIGVGVFSALIVAAIRDGGDTTALIVGLLIAAPLAALFHWLESWLAHAMAYQLLADMRVKLYDKLERLAPAYLLQRRSGDLVALATQDVEMVEYFYAHTIAPAIVSVLVPLSVLGFLGFYSWPVALALLPFLAYALVSPVRGRRRVDALGDKAREALGEMSAHTTDTIQGLADLTAFQATGRRRDQFLKVADHYRARRLAILRDLSRQTAWFEIAMGLGGLAVAVVGALQVQAGTLPAGMLPLLVLIALATFLPVSEISQVSRQLADTIAATRRLHVVANEPEPVVDGPLPAPVAAHGLSLAFERVSFAYPGKRQDTLRQLSFTAPAGATVAIVGASGAGKSTVASLLLRFWDPREGAVKLDGVDVRQLQLDGLRERVALVTQDTYLFNDTLEGNIRLARPEASREDLMRALEQAALADFVQRLPEGLATRVGERGMQLSGGQRQRISIARAFLKNAPVLILDEATSHLDTLSEMQVRGALDVLMRHRTTLVIAHRLSTIRDADLILVLDRGTLAESGTHDQLLRKQGVYARLASHQGGYAAAGAASLPG
>CP023270.1|AVJ27503.1|2353925_2354861_+|transcriptional-regulator
MSDSSTRTPPLAALRAFEAVARLGSLSRAAAELNVTKSAVSHQLRALEADLGAPLLRRGGTVRRAETTEAGAALLASVQQALTLLETACRNVRATARGKRRYTLNVSANPSLAALWLAPRIGRFIELHPDIDIQVYLHASQDPAWKTQDIDLAFLHVRAMGPHIAAPGDIPLMSETVVPVCSPALVAEADRNDPRVFLRHRWLEEKHIDSPETDWRTWRPRLGLGADDWQDPMVLSGLSTVVAAAAAGVGIALGRAPLIDEDLASGRLVPLTPHLRMPGSWGYVMRIHANRPMDPSLPALVEFLSEEGRRA
>CP023270.1|AVJ27504.1|2354930_2355710_-|ATP-binding-protein
MNDTMIRLTDVSKAYGEVPVLDKVNLEVKRGEFLVLLGASGCGKSTLLNLMAGFITPNTGSVEINGKKVTDVTAACGMVFQQYALFPWRTVQENVEFGLKMRGMSRQERAPIARKFIEMVGLKHAADKFPHALSGGMKQRVSIARVLANDPDVMLFDEPFAALDAMTRQVLQDQLLSIYEQSGKTIVFITHSIDEALTLSTRMAVMGSKPGRIVQDIQNDLPHPRSADVQLSPRFVELKRAIWERVQEEVTRSMELTAD
>CP023270.1|AVJ27505.1|2355706_2356477_-|ABC-transporter-permease
MSTRSSSRETRLLWISVFSLLGFLLMWEGLCRAGAVDPIFLPAPSQVLARALSMSDQGTLFYNVLASTRRVMVGFLAAVIVAIPLGILLGTSKVARAVFDPIISFLRPLPSMSWIPLSLLWFGITETQKYSIVFMGSFVPALLYVMEASRSIDPVLVRAARNLGANRWQVMREVLFPGCLPQILSGMKIILGLSWTCVISAELVASKEGLGFMIMNGKEFFQTDTVVLGMVLISFTVLVTDLCLRLLERWVLAWQR
>CP023270.1|AVJ30960.1|2356495_2357473_-|taurine-ABC-transporter-substrate-binding-protein
MLVRTAALAGASALGFPMIGRAAGASYTYGGSAWLGHYSAYIALKTGLFAKQGLDIKWQSFATSSDRMSAVMAGNVDLAGTGVVSSLALMAAGARQFQVIATPNNFGRAEGVLVRDNVKSVADLKGKKIGVTYASSAHVLLLDVLRQAGLNPDRDVSIINLPATNLLSAYQGSQIDAAVAWTPAFDRIKAVPGTHVLLDDTAFSLYKQYAITPGPDVLLTHAKLGKENPDAVRKFLQAVFQANAMLTNQPEEAAGVLLELTGLSKDEQLAVIKQTQWYSAEDQKALMIEPGNFVNGMQKLAEMLVSLKQIDRAPTVKDWVQSSYL
>CP023270.1|AVJ27506.1|2357697_2358885_+|amino-acid-dehydrogenase
MKSFDVIVIGAGVIGSSVAFHLAEFGAKNVLVLDRETIGAGTTSQSSGILRTHYSVRENVELAQRSWSVFNNFASYLGDEEASCGLVKCGYLITAADDDKLEPLRGALAQQQAQGIALELLNAAQARELLPIASFDNAALIGYEPEAGFADAYLVATSFARGARRRGVTIRENVNVQRLIIDNGRVTGVVTSEGDYNAPLVISTQNIWTPELAGWTGVAMPVVPERHAVLALECDAAPYTYSMPVFKDLASPGMLYCRSYGGNQMLVSEGIVGEALQKSDAEQGDIPLDYVAEVGAQVADRFPAYETAGLASSWTGVYDVTPDWNPVLGRVPGVEGLIVGFGFSGHGFKLSPTVGRVLAQEALGLATDVSLTPYELGRFQRGALLTGKYGLGAVS
>CP023270.1|AVJ27507.1|2358868_2359432_+|hypothetical-protein
MAQSPDPRGPVRASWLALPPEPWKNGGGVTRTLAVDPAGRWRVSIADIDRDGPYSRFSGYDRVSVVLAGDGVMLQGEGVSVALRPREPAVFGGDALLQSTLVGGPVRVLNLFVLRGAATASVTCSGAAAQRAEVGSLLAGVDERAVTRLVVTAQDYQISRVANACTAATQNDFAVILDITVQESVPN
>CP023270.1|AVJ27508.1|2359500_2360250_+|electron-transporter-RnfB
MKVLAAVKRVVDYNVNVRVKADQSGVDIGNVKMSMNPFDEIAVEAAVRLKEQGAAAEVVAVSCGTAQSQETLRTALAIGADRGVLVQTDAALQPLEVAKLLRAVVDKEAPALVILGKQAIDDDACQTGQMLAALLGWPQATNASAIAIGEGTARVTREVDGGLEVVELTLPAIVTADLRLNEPRYVTLPNIMKAKKKPLDVETPDALGVDPVSRLQTLRVEEPSARAPGIKVADVAALVDKLKNEAKVI
>CP023270.1|AVJ27509.1|2360249_2361182_+|electron-transfer-flavoprotein-subunit-alpha
MTVLVIAEHDNRALNGATLNAIAAAARLAMPIHVLVAGGDAQPVAEAAARVAGVEKVLLAQAPQFADGLPEALAAQAVAVAAGYSHVFLAATAQGKGVAPRIAALLDVAQVSDVIEVLAPDTFKRPIYAGNAIATVKSGYSVVVATIRPTAFDAVSAEGGSATLEVVEAVTGAGLSRFVSREIAVSERPDLGGARAVVSGGRGLGSAENFKLLDPLAEKLGAALGASRAAVDAGYAPNDWQVGQTGKIVAPELYVAVGISGAIQHLAGMKDSKVIVAINKDGDAPIFGVADYGLVGDLFEAVPALTSSLS

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Crispr_ID: CP023270_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023270_3

5558821-5558948

Orphan

Consensus_repeat	Method
CCCCTTGGGGGGCAGCAAGCGAGCGAAGCGAGTGCGGCGTGGGGGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023270_3

>merge|CP023270|3|5558821-5558948|CRISPRCasFinder
CCCCTTGGGGGGCAGCAAGCGAGCGAAGCGAGTGCGGCGTGGGGGCCGCCCCGCCGCTCGGCCGCCCGAAGGCGGGGCAGCCCCCTCGGGGGGCAGCAAGCGAGCGAAGCGAGTGCGGCGTGGGGGCC

>CP023270|3|3|5558821-5558948|CRISPRCasFinder
CCCCTTGGGGGGCAGCAAGCGAGCGAAGCGAGTGCGGCGTGGGGGCC	GCCCCGCCGCTCGGCCGCCCGAAGGCGGGGCAGC
CCCCTCGGGGGGCAGCAAGCGAGCGAAGCGAGTGCGGCGTGGGGGCC

Protein	Signature genes	Signature genes Name	Protein_function
CP023270.1\|AVJ30106.1\|5552588_5553542_-\|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl\|CDD\|163676
CP023270.1\|AVJ30110.1\|5557654_5557855_+\|thiamine-biosynthesis-protein-ThiS	unknown	unknown	gnl\|CDD\|168159
CP023270.1\|AVJ30103.1\|5549406_5549955_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|238045
CP023270.1\|AVJ30111.1\|5558157_5558604_+\|peptidoglycan-binding-protein-LysM	unknown	unknown	gnl\|CDD\|236880
CP023270.1\|AVJ30105.1\|5551526_5552513_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
CP023270.1\|AVJ31225.1\|5560554_5561304_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226621
CP023270.1\|AVJ30109.1\|5556701_5557643_+\|prolyl-aminopeptidase	unknown	unknown	gnl\|CDD\|130316
CP023270.1\|AVJ30116.1\|5563071_5565261_+\|hybrid-sensor-histidine-kinase/response-regulator	unknown	unknown	gnl\|CDD\|223715
CP023270.1\|AVJ31224.1\|5555988_5556702_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	unknown	unknown	gnl\|CDD\|234649
CP023270.1\|AVJ30114.1\|5561673_5562252_+\|1,6-anhydro-N-acetylmuramyl-L-alanine-amidase-AmpD	unknown	unknown	gnl\|CDD\|236984
CP023270.1\|AVJ30108.1\|5554853_5555750_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176113
CP023270.1\|AVJ30119.1\|5570919_5572053_+\|hypothetical-protein	unknown	unknown	unknown
CP023270.1\|AVJ31226.1\|5565542_5568128_+\|type-VI-secretion-system-tip-protein-VgrG	unknown	unknown	gnl\|CDD\|274542
CP023270.1\|AVJ30104.1\|5549951_5551223_+\|toxin-HipA	unknown	unknown	gnl\|CDD\|377920
CP023270.1\|AVJ30120.1\|5572049_5573228_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371775
CP023270.1\|AVJ30117.1\|5568551_5568833_-\|hypothetical-protein	unknown	unknown	unknown
CP023270.1\|AVJ30118.1\|5569372_5570647_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371775
CP023270.1\|AVJ30107.1\|5553538_5554732_-\|formyl-CoA-transferase	unknown	unknown	gnl\|CDD\|367110
CP023270.1\|AVJ30113.1\|5561305_5561572_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379280
CP023270.1\|AVJ30115.1\|5562270_5562894_+\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|198289

Protein	Function_ID	Function_description	E-value
CP023270.1\|AVJ30106.1\|5552588_5553542_-\|hydroxymethylglutaryl-CoA-lyase	gnl\|CDD\|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	3.11771e-155
CP023270.1\|AVJ30110.1\|5557654_5557855_+\|thiamine-biosynthesis-protein-ThiS	gnl\|CDD\|168159	PRK05659, PRK05659, sulfur carrier protein ThiS; Validated.	6.81709e-25
CP023270.1\|AVJ30103.1\|5549406_5549955_+\|transcriptional-regulator	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.31139e-07
CP023270.1\|AVJ30111.1\|5558157_5558604_+\|peptidoglycan-binding-protein-LysM	gnl\|CDD\|236880	PRK11198, PRK11198, LysM domain/BON superfamily protein; Provisional.	1.45382e-72
CP023270.1\|AVJ30105.1\|5551526_5552513_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	9.0074e-137
CP023270.1\|AVJ31225.1\|5560554_5561304_+\|hypothetical-protein	gnl\|CDD\|226621	COG4137, COG4137, ABC-type uncharacterized transport system, permease component [General function prediction only].	5.6617e-50
CP023270.1\|AVJ30109.1\|5556701_5557643_+\|prolyl-aminopeptidase	gnl\|CDD\|130316	TIGR01249, Putative_proline_iminopeptidase, proline iminopeptidase, Neisseria-type subfamily. This model represents one of two related families of proline iminopeptidase in the alpha/beta fold hydrolase family. The fine specificities of the various members, including both the range of short peptides from which proline can be removed and whether other amino acids such as alanine can be also removed, may vary among members.	4.88506e-144
CP023270.1\|AVJ30116.1\|5563071_5565261_+\|hybrid-sensor-histidine-kinase/response-regulator	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	2.55189e-53
CP023270.1\|AVJ31224.1\|5555988_5556702_+\|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB	gnl\|CDD\|234649	PRK00121, trmB, tRNA (guanine-N(7)-)-methyltransferase; Reviewed.	3.64014e-99
CP023270.1\|AVJ30114.1\|5561673_5562252_+\|1,6-anhydro-N-acetylmuramyl-L-alanine-amidase-AmpD	gnl\|CDD\|236984	PRK11789, PRK11789, 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD.	5.96406e-114
CP023270.1\|AVJ30108.1\|5554853_5555750_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|176113	cd08421, PBP2_LTTR_like_1, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.49873e-90
CP023270.1\|AVJ31226.1\|5565542_5568128_+\|type-VI-secretion-system-tip-protein-VgrG	gnl\|CDD\|274542	TIGR03361, VI_Rhs_Vgr, type VI secretion system Vgr family protein. Members of this protein family belong to the Rhs element Vgr protein family (see TIGR01646), but furthermore all are found in genomes with type VI secretion loci. However, members of this protein family, although recognizably correlated to type VI secretion according the partial phylogenetic profiling algorithm, are often found far the type VI secretion locus.	0
CP023270.1\|AVJ30104.1\|5549951_5551223_+\|toxin-HipA	gnl\|CDD\|377920	pfam07804, HipA_C, HipA-like C-terminal domain. The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species. This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells, but it is usually tightly associated with HipB, and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products.	1.10777e-56
CP023270.1\|AVJ30120.1\|5572049_5573228_+\|hypothetical-protein	gnl\|CDD\|371775	pfam11876, DUF3396, Protein of unknown function (DUF3396). This family of proteins are functionally uncharacterized. This protein is found in bacteria and viruses. Proteins in this family are typically between 302 to 382 amino acids in length.	1.22749e-50
CP023270.1\|AVJ30118.1\|5569372_5570647_+\|hypothetical-protein	gnl\|CDD\|371775	pfam11876, DUF3396, Protein of unknown function (DUF3396). This family of proteins are functionally uncharacterized. This protein is found in bacteria and viruses. Proteins in this family are typically between 302 to 382 amino acids in length.	4.39907e-51
CP023270.1\|AVJ30107.1\|5553538_5554732_-\|formyl-CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.31402e-143
CP023270.1\|AVJ30113.1\|5561305_5561572_+\|hypothetical-protein	gnl\|CDD\|379280	pfam13584, BatD, Oxygen tolerance. This family of proteins carries up to three membrane spanning regions and is involved in tolerance to oxygen in in Bacteroides spp.	0.000240583
CP023270.1\|AVJ30115.1\|5562270_5562894_+\|glutathione-S-transferase	gnl\|CDD\|198289	cd03180, GST_C_2, C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, unknown subfamily 2; composed of uncharacterized bacterial proteins, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain.	3.46329e-43

>CP023270.1|AVJ30111.1|5558157_5558604_+|peptidoglycan-binding-protein-LysM
MGLLNFIKDVGEKLFGASEAKAATAEELKKELDKHGLNADGLQITVDGDKVTVAGQALSTEDAEKISLALGNTVGVAAVDNQLQVKQATPEAKMYTVQKGDNLWKIAEAQYGKGQGAKNTLIFEANKPMLTSPDKIYPGQVLRIPPLS
>CP023270.1|AVJ30110.1|5557654_5557855_+|thiamine-biosynthesis-protein-ThiS
MHITLNGDAREFPLDTTVNELLETLGYAGKRVAVERNGEIVPKSQHAQTALSDGDQIEIVVAVGGG
>CP023270.1|AVJ30109.1|5556701_5557643_+|prolyl-aminopeptidase
MLYPPIEPYRQGMLDTGDGHQIYWEMCGNPNGKPAVFLHGGPGSGCSPVHRQLFDPQRYNVLLFDQRGCGRSQPHASLDNNTTWHLVADIERLRTEVMGAEKWLVFGGSWGSTLGLAYSETHPAHTSELVLRGIFGLRRAEIQWFYQEGASWLFPDRWEEYLAPIPEAERGDLVTAYHKRLTGNDPVEQLRAAKAWSKWEDSTITLLPSPRHQQSHAADRAALAFARIENHYFFNAGFMEEGQLIRDAQKLRGIPGTIVQGRYDVCTPARTAWDLHRAWPEAQFHLVPDAGHAFDEPGTLARLIAATDAYAKQ
>CP023270.1|AVJ31224.1|5555988_5556702_+|tRNA-(guanosine(46)-N7)-methyltransferase-TrmB
MQAALASAAYAPNSPGAAHIRSFVHRRGHITQGQLAALERLMGQWSLPYAPRRLDPAAAFGRQAPTVLEIGFGMGETTEKIALARPGDNFLGVEVFNAGVGSLLRRIEDSSIQNLRIIQHDAVEVVRDMIAPDSLAGVHIYFPDPWPKKRHHKRRLIQPAFVSLLASRIAPGGYIHCATDWEDYAVQMLEVLSGEPLLKNTVDGYAPRPDYRPLTKFETRGLRLGHGVWDLIFKRVA
>CP023270.1|AVJ30108.1|5554853_5555750_-|GntR-family-transcriptional-regulator
MNFARIDLVTLALFVAVARQGSISAGARQSHLAVGAASKRISDLEAALGSPLLFRNAAGVELTDAGQACVVHALRVLQEVEQMAGALSDFAQGVRGQVRIAANTSSLTQFLPEDLAAFMDEHPAVRIDLEEQNSSDIVTAVLENRADIGVFADRTPAEGLATFPYRLDELVLIVPQRHPLAAEPQVAFADTLAYDYVGLPPATSLATRLSEESGRMGRAMRLRIQVRSFDAICRMVAATRGVGILPRIAAEPHARSMPIRLIPLTDEWARRWLLLGVRDADTLTVAARLLLAHLRGEG
>CP023270.1|AVJ30107.1|5553538_5554732_-|formyl-CoA-transferase
MAGQILAGIRVLELGQLIAGPFAAKTLADFGAQVIKIEPPGQGDPLRKWRLLHEGTSVWWEAQSRNKQSVCVDLRQQEGQDIVRMLAREADVLIENFRPGTLEKWGLSWEALHELNPRLIMLRISGYGQTGPKAREPGFAAIGEAMAGLRYLNGEPGRAPVRAGLSLGDTIAGLHGALGVMLALYQRDARGGVGQVIDTALYESLFNLSESLLPEYSVFGAVREPAGASLPGIAPSNAYPCQDGYVLIAGNGDAIYTRLMARIGRDDLGQDPALAHNDGRARRVQEIDAAIGAWTHERRIDDVLAAMLEAGVPAGRIYSIADIAKDPHYRARNAITSMESAAGVQVEMPAVFPYLSSNPGAVRERAPTLGEHTDAVLASAGLTEEQRAALRAKGVIA
>CP023270.1|AVJ30106.1|5552588_5553542_-|hydroxymethylglutaryl-CoA-lyase
MNHGPARIEINEVGPRDGLQIEKTMVSTDDKVAFVDALSDCGFARIEVTSFTSPKAIPALADAVDVMRRIRRRPGVIYTALVPNVRGLERALEAGTDEMNLVMSCSETHNRANLRMTRDQSFAELSQVLTAAAKAGAPCNVSLSTAFGCPFDGDVPADTVLDLAARLVDAGAAGITLCDTTGMAFPTQVAALCEQAAARLPATALTVHLHNTRGMALANAIAAWQTGITRFDAAAGGLGGCPYAPGASGNVNTEELVHMFACMGVETGVSLEPLLAIVRSLPGLVQRDLSNVLLQAGPRLALHAPPAWLAERFAADA
>CP023270.1|AVJ30105.1|5551526_5552513_-|ABC-transporter-substrate-binding-protein
MASFRLPTALRVSAAFALITAAGAASAQADFPNRPVTLIVSAAPGGTTDIAARLIAQPLGAALGQSVVVENKPGASGGIAAQAVARAKPDGYTLLLQYSGFQVITPHVTPAAGWDPIKDFAPVANVLSAPQVVVVRPDLPIKSLKELVAYAKANPGKLNYASSGNGSLQQVATELLNQMAGTQITHIPYKGTGPALNDLLGGAVDMTITTPPPLLGQIAAGKLRALAVTGNARLPSLPDVPTAAEAGYPDLIVSSWFAMYAPKDTPAPVVDKIAGEIQKIMKTDGFRKKAAEQGAEAIFMGPKELGAYTQTELDRWGKVVKAANITAN
>CP023270.1|AVJ30104.1|5549951_5551223_+|toxin-HipA
MTMIAVYADWKGLQQPQRLGFLNSRRTRAHETFEFQYDPAALADPVIGQLVLDPKLFLFEGPQYPTAPQDRFGVFADSSPDRWGRMLMDRRLERDIRAGILPAGTRLYETDYLLGVHDLYRVGALRYKREDQGEFLDNANGLAAPPFTEIRALEQAARALEQDQDNASQQGQQWLRMLIAPGGSLGGARPKASVADEQGHLYIAKFPSARDEYDVGGWEMVINALAVGCGLNVAAAEARKFASDHHCFMVRRFDRTDDGKRLHFASAMTMTGHVDGEDASTGVSYLDLAEVLIRHGAQTNADLRELWSRIVFNLLVSNTDDHLRNHGFILIPGSGWRLSAAYDMNPVPIADGLKLNITEADNALDLELARDVAAYFRLSLVDADEIIDEFQGIVRQWRTLARSLGLPAREQDRMAEAFRLAQN
>CP023270.1|AVJ30103.1|5549406_5549955_+|transcriptional-regulator
MAKKTAPLMPATEKLLAEFGERLRLARLRRRITAKQVAERAGMSPMTLRSLEAGGAGVTIGAYLSVMQVLGVERDLALLAAEDELGRRLQDSRLVKASRLGHVPPITNRDMGTRKSQPSLETGKPRARNASSQVMANQDNASSPSTKADPTPASAKSTTTTSTSLASLLKPASKMKKKGAKT
>CP023270.1|AVJ31225.1|5560554_5561304_+|hypothetical-protein
MEQTGRIARLCLLGALILHGIGLQQSMLGSQHLFIGWALALSAAIWLGMVVFWLESLLVRIDGLQLLLLPAAAIASGLAAVFPQGQFVPHADDPWLRVHLLIALAAYGLITIAALHAMMMALLDRHLHRPLDAPAERSIIGRVLDSQPPLLVQEQLLFRIIWIGFVVLTLAVGSGSVASMKLTGKILPFDHKTVFTLLSWLTFGVLLAGRHIWGWRGRVALRWTLTGFGFLILAYTGSRFVLEMILHRG
>CP023270.1|AVJ30113.1|5561305_5561572_+|hypothetical-protein
MGKLLFWIVLIILVLFVARIAGRMAAQRQADAQGGQKKKAQGAQPPPAIESMVRCAHCGIHLPRSEALLQNGQTWCSPDHARLGPAKR
>CP023270.1|AVJ30114.1|5561673_5562252_+|1,6-anhydro-N-acetylmuramyl-L-alanine-amidase-AmpD
MPLLLDRHGWLAPAPGVSLLRSPNCDARPADTQISLLVVHNISLPPGQFGGPEVAGLFLNTLDYGSHPWLERLRGLRVSAHFFIRRDGRIVQFVSTNRRAWHAGVSRFAGRERCNDFSIGIELEGTDTLPYTGEQYASLRRLTHTLRARYPLVAAQGHEHIAPGRKTDPGPAFDWTRFGRDSGFARRHLPPA
>CP023270.1|AVJ30115.1|5562270_5562894_+|glutathione-S-transferase
MLKIWGRLTSVNVQKVMLAVRELALPHTFVQAGGPFGVVDTADYAAKLNPNRLVPVIDDGGVILWESNAIVRYLAARYGAGTLWPEDVCLRADADRWMDWQATEWQPAMVPAFLGLIRTPEDRRDKAAIANSIKRSNDRALILDQALQGREFIAGRHLTMGDIALVAAAHRWLALPIERPDTPALSAWYRRVMMRPAPQGVLTLPLE
>CP023270.1|AVJ30116.1|5563071_5565261_+|hybrid-sensor-histidine-kinase/response-regulator
MHLTQEPPESAGQAALDQEQRQLLLLVASGAPTGSCLEALTEAVCRLAPGTRACVLLTSPDRVTVADAYSTHLPASIACPLRGLPMHEALFASDDPAIRRGNPVECHDIEQSTMWAESWRTICHANSIHACHARAAMAPDGTPVGWFLLCLPQVRHCTPWEQRVAEFGALATSIVVERDRAAADLRNEVDALSRLQALSAELVGPGEFEPLLKKILAAAADISGTEKGNIQIYDPAKNTLRIAVHQGLSARLVEHFAEDGWVASCAEAAQHLERLVVPDVEQLTDLQGTLGLEIVMEDNIRSIQCTPLLSRSGQLLGMLNNHYRWPGGPTPEALRYIDLLARQAAELLERHIAESELARERRHKDEFLAVLAHELRNPLAALRNMLEVLKRAERDPGLTARAREVMDRQLRQLVRLVDDLLDVNRINRGKLELRLTALTLDTVLQHAVEACKPALEQHGHRLRLVQPDAQITLQGDAERLTQVFGNLLSNAAKYTPPGGDIELFVEPGKDSVDITVRDNGSGIPPDQLDRIFEMFTQVDRTLERAQGGLGIGLMLVKRLVEMHGGTVRAHSEGQGKGSAFVVRLPVTGIQEVAPQRPAGALSPVARKVLVVDDNRDAVESLVAVLAIEGHDVVAAYDGKEAITVGEQVRPQVILMDIGMPGMNGHEACRHIRTLDWGQRATILALSGWGQEEDRRASMEAGFDAHLVKPVDMDVLLEMLSTIEHCGNAR
>CP023270.1|AVJ31226.1|5565542_5568128_+|type-VI-secretion-system-tip-protein-VgrG
MPIQSDLRFTFAVGDEPFEVVAFTLQEGLSETFLLEVDLASANAAIDFGQVLDRAALLTLWQGDTPVRYVHGAVSSFVQGDTGFRRTRYRAVVEPRLARLKLSSDWRIFQALTVPQIAEAVLKAHGLTHDYEQRNTSEHQPREYCVQAGDTDYHFVERIMREEGFFYSFRHSAEGHRLVHSDRLFIHGRVGDEPVQYNPTPGGDQPQPALRRFAYTENVRTARQTQRDYTFHHPRYAHQHSRDGQDLDHQGRGYERYDYPARAKFDEAGKPFAGNRLRGHRRDARIALVEGDDPRLQPGISFTLAGHPREDMNRGWRPIRIVHRGKQHASLAEESAEAQSGTHYRYEAELVPDDAEWRAEPLPRPHIDGPQNAVVVGPPNEEIHTDEYGRVKVQFPWDRVGKHDGFSSCWIRVSQNIAGATWGHMAIPRVGHEVIVSYFDGDPDQPVITGRVYNRLQLPPYELPKFKDLATVKSKEHKGKQASELRLDDTPSQISAALMNDHGASHLHLGYLTHPRPIGGEPRGEGFELRTDLHGTLRAAQGLLLTTESQANAQGGQLDREEIVAVLEAALHLARSLGNYAGEHQGAPHDAEPRRDLTALVRALGHGANDQTNGTGEGTAPVVALSAPAGIAAGTPLSIALGAGEHLDAVAHANLQLTAGERVVVNAGNGLGTFAQRGDMRHIAHTGQLRLQAQHNNICIDADKSVEVRANNNHVTVSAEEHITLLCGGAYIKMAGGNIEMGMPGVFTVKATDHNLTGPATMVPTLGQFSGLPGPFEEFFVLRNASTNKVLPDHAYEIVRANGDIVRGRTDAQGRTQVVTSDTSEPLEVSAIPDPNDLLHLNASYWDGAGDYSLDFLRNPN
>CP023270.1|AVJ30117.1|5568551_5568833_-|hypothetical-protein
MKQAKLIAGASYISVSSSLVIRKRVLSKLHFNHTSQIWLTVLRRTAQLVVDDPNDVGNPHWAFRHYLDILPNSVLDIWRQRHRNHLLKLIQAQ
>CP023270.1|AVJ30118.1|5569372_5570647_+|hypothetical-protein
MAGLSGMGSQPTAPSAHGTTVSILGRCAGDENMTDFFKEFAAERWYFTFADEEDNTLLVQQVGIVAIFHLVDAYLPVRRKGIAEAFSLYHELYGDKLKGGYREDKRMIVRPFAKMDFEAYRDYIVGTSPMNVVEFKCMSRLSLGHVSDYMFGVYSPAGWYEQVHKPLTTVRAYLPVDELVGEGKARFEDFLLQCCALLRPLHGAAGLGIQECHDWEDYQTLEHETAWAYRGVDICGPTGDKNLRKGYKNLNWYTFLAHHWIATLGTPEELKTKINDERVALLPYKWGTAIRAGDWPALGKAETDPTPELYVKVNNAIRSLRVQDVESLHYGSIAGEVRFNPLTSNLWLRRFDTLQEIKAVIDESGNVKTDERHFLRMPSGTPCPWPGIWICEEEPSQGRKTFMHNELLPDVNGQVVTWRLVKAL
>CP023270.1|AVJ30119.1|5570919_5572053_+|hypothetical-protein
MYQRTVALMIRADNELFEYRWPYCAEVGYDMTKTPPAPIMSKKQPHRPSSFPLSQYKRISSRQFPQYSSVEVVVDILGLDELEEMIPVPLPPDVENGIWQDIQVVQKRPLRIPDVVRVIDHTMGGVPQYSQPNLAGVIEMKFGRDALSTEQKAAYEDIAGKSDRFRLLNTDRCDRADRRQRREWMTAAQSEPVYKPVSQVMSLPSRASADPHGLVVGLIDAEHQAARRVLEVGPRSTGTPVLTAGAAMREADADAARVRAQVGLSLAGPFVLIGATGLGAGMASLAGSNAVLSGSTLAARAGPRFVHFTRLVTWGGAGSAGAAVAYAQSEDGSSVPVSSSERQRQWEAYQEWEASQREQPRTEQLYLFWADAPETKQ
>CP023270.1|AVJ30120.1|5572049_5573228_+|hypothetical-protein
MTNFFKEFDAERWYFTFADEDDNTLIVQQVGIVAVFHLVDAYLPVRRKGIAEAFSLYHELYGDKLKGGYRADKRMIVRPFSKMGFESYRDYVVDTSPMDVIEFDCMSTLSLGHASDYMFGVFSPAGWYEQVHKRLTTVRAYLPVEELVGEGRARFESFLLKCCALLRPLHGAAGLGIQECHDWEDYQTLEHETAWAYRGVDLCGPSEKKNLRDGYKNLNWYTFLAHHWIATLGTPEDLKAKLNDDRIELLPYKWGTAIRAGDWPALGKAETDPTPELYVKVNNAIRSLRVQDVESLHYGSIAGEVRFNPLTSNLWLRRFDTLQEIKAVIDESGNVKTDERHFLRMSSGTPCPWPGIWICEEEPSQGRRTFMHNELLPDVNGQVVTWRLVKAL

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Crispr_ID: CP023270_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP023270_4

5865507-5865636

Orphan

Consensus_repeat	Method
GCCGCCCGTGTTTTGTTGGTGGCGGCATTGCGCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP023270_4

>merge|CP023270|4|5865507-5865636|CRISPRCasFinder
GCGCTGGGTTTTTTGTTGGTGGTGGGGCTGTGCCGCCCGTGTTTTGTTGGTGGCGGCATTGCGCCGCACGTGTTTTTGTTTGTGGCGGCGCTTCGCCGCCCATGTTTTGTTGGTGGCGGCATTGCGCCGC

>CP023270|4|4|5865507-5865636|CRISPRCasFinder
GCGCTGGGTTTTTTGTTGGTGGTGGGGCTGTGCCGC	CCGTGTTTTGTTGGTGGCGGCATTGCGCCGCACGTGTTTTTGTTTGTGGCGGCGCTTC
GCCGCCCATGTTTTGTTGGTGGCGGCATTGCGCCGC

Protein	Signature genes	Signature genes Name	Protein_function
CP023270.1\|AVJ30374.1\|5861211_5861538_-\|monothiol-glutaredoxin,-Grx4-family	unknown	unknown	gnl\|CDD\|188046
CP023270.1\|AVJ30369.1\|5857097_5858060_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176107
CP023270.1\|AVJ30385.1\|5874905_5876936_-\|TonB-dependent-receptor	unknown	unknown	gnl\|CDD\|224544
CP023270.1\|AVJ30386.1\|5877155_5878205_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270307
CP023270.1\|AVJ30368.1\|5855892_5856990_-\|mandelate-racemase	unknown	unknown	gnl\|CDD\|239432
CP023270.1\|AVJ30377.1\|5863776_5865051_-\|glutamyl-tRNA-reductase	unknown	unknown	gnl\|CDD\|234592
CP023270.1\|AVJ30383.1\|5872322_5872898_-\|hypothetical-protein	unknown	unknown	unknown
CP023270.1\|AVJ31243.1\|5874038_5874824_-\|hydroxypyruvate-isomerase	unknown	unknown	gnl\|CDD\|226149
CP023270.1\|AVJ30384.1\|5873022_5873994_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
CP023270.1\|AVJ30382.1\|5871409_5872315_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|182525
CP023270.1\|AVJ30378.1\|5865839_5867204_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225718
CP023270.1\|AVJ30370.1\|5858016_5858556_-\|cupin	unknown	unknown	gnl\|CDD\|224704
CP023270.1\|AVJ30373.1\|5860643_5861204_-\|3-octaprenyl-4-hydroxybenzoate-carboxy-lyase	unknown	unknown	gnl\|CDD\|235677
CP023270.1\|AVJ30380.1\|5870027_5870498_-\|ArsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
CP023270.1\|AVJ30381.1\|5870703_5871348_+\|lysine-transporter-LysE	unknown	unknown	gnl\|CDD\|224199
CP023270.1\|AVJ30372.1\|5859550_5860624_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379646
CP023270.1\|AVJ30375.1\|5861764_5862598_-\|protein-(glutamine-N5)-methyltransferase,-release-factor-specific	unknown	unknown	gnl\|CDD\|236467
CP023270.1\|AVJ30371.1\|5858568_5859363_-\|metal-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
CP023270.1\|AVJ30379.1\|5867548_5870011_+\|mechanosensitive-ion-channel-protein-MscS	unknown	unknown	gnl\|CDD\|225803
CP023270.1\|AVJ30376.1\|5862608_5863691_-\|peptide-chain-release-factor-1	unknown	unknown	gnl\|CDD\|234801

Protein	Function_ID	Function_description	E-value
CP023270.1\|AVJ30374.1\|5861211_5861538_-\|monothiol-glutaredoxin,-Grx4-family	gnl\|CDD\|188046	TIGR00365, TIGR00365, monothiol glutaredoxin, Grx4 family. The gene for the member of this glutaredoxin family in E. coli, originally designated ydhD, is now designated grxD. Its protein, Grx4, is a monothiol glutaredoxin similar to Grx5 of yeast, which is involved in iron-sulfur cluster formation. [Energy metabolism, Electron transport].	4.52956e-63
CP023270.1\|AVJ30369.1\|5857097_5858060_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176107	cd08415, PBP2_LysR_opines_like, The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate-domain of LysR-type transcriptional regulators, OccR and NocR, involved in the catabolism of opines and that of LysR for lysine biosynthesis which clustered together in phylogenetic trees. Opines, such as octopine and nopaline, are low molecular weight compounds found in plant crown gall tumors that are produced by the parasitic bacterium Agrobacterium. There are at least 30 different opines identified so far. Opines are utilized by tumor-colonizing bacteria as a source of carbon, nitrogen, and energy. NocR and OccR belong to the family of LysR-type transcriptional regulators that positively regulates the catabolism of nopaline and octopine, respectively. Both nopaline and octopalin are arginine derivatives. In Agrobacterium tumefaciens, NocR regulates expression of the divergently transcribed nocB and nocR genes of the nopaline catabolism (noc) region. OccR protein activates the occQ operon of the Ti plasmid in response to octopine. This operon encodes proteins required for the uptake and catabolism of octopine. The occ operon also encodes the TraR protein, which is a quorum-sensing transcriptional regulator of the Ti plasmid tra regulon. LysR is the transcriptional activator of lysA gene encoding diaminopimelate decarboxylase, an enzyme that catalyses the decarboxylation of diaminopimelate to produce lysine. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.40768e-29
CP023270.1\|AVJ30385.1\|5874905_5876936_-\|TonB-dependent-receptor	gnl\|CDD\|224544	COG1629, CirA, Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism].	3.51809e-50
CP023270.1\|AVJ30386.1\|5877155_5878205_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270307	cd13589, PBP2_polyamine_RpCGA009, The periplasmic-binding component of an uncharacterized ABC transport system from Rhodopseudomonas palustris CGA009 and related proteins; contains the type 2 periplasmic-binding fold. This group represents the periplasmic binding domain that serves as the primary high-affinity receptor of an uncharacterized ABC-type polyamine transporter from Rhodopseudomonas palustris Cga009 and related proteins from other bacteria. Polyamine transport plays an essential role in the regulation of intracellular polyamine levels which are known to be elevated in rapidly proliferating cells and tumors. Natural polyamines are putrescine, spermindine, and spermine. They are polycations that play multiple roles in cell growth, survival and proliferation, and plant stress and disease resistance. They can interact with negatively charged molecules, such as nucleic acids, to modulate their functions. Members of this family belong to the type 2 periplasmic-binding fold superfamily. PBP2 is comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.63945e-75
CP023270.1\|AVJ30368.1\|5855892_5856990_-\|mandelate-racemase	gnl\|CDD\|239432	cd03316, MR_like, Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. Members of the MR subgroup are mandelate racemase, D-glucarate/L-idarate dehydratase (GlucD), D-altronate/D-mannonate dehydratase , D-galactonate dehydratase (GalD) , D-gluconate dehydratase (GlcD), and L-rhamnonate dehydratase (RhamD).	2.61918e-89
CP023270.1\|AVJ30377.1\|5863776_5865051_-\|glutamyl-tRNA-reductase	gnl\|CDD\|234592	PRK00045, hemA, glutamyl-tRNA reductase; Reviewed.	0
CP023270.1\|AVJ31243.1\|5874038_5874824_-\|hydroxypyruvate-isomerase	gnl\|CDD\|226149	COG3622, Hfi, Hydroxypyruvate isomerase [Carbohydrate transport and metabolism].	8.26566e-124
CP023270.1\|AVJ30384.1\|5873022_5873994_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	7.69905e-118
CP023270.1\|AVJ30382.1\|5871409_5872315_+\|EamA-family-transporter	gnl\|CDD\|182525	PRK10532, PRK10532, threonine and homoserine efflux system; Provisional.	7.7171e-104
CP023270.1\|AVJ30378.1\|5865839_5867204_-\|hypothetical-protein	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	4.5384e-20
CP023270.1\|AVJ30370.1\|5858016_5858556_-\|cupin	gnl\|CDD\|224704	COG1791, COG1791, Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown].	1.22056e-70
CP023270.1\|AVJ30373.1\|5860643_5861204_-\|3-octaprenyl-4-hydroxybenzoate-carboxy-lyase	gnl\|CDD\|235677	PRK06029, PRK06029, UbiX family flavin prenyltransferase.	1.01138e-112
CP023270.1\|AVJ30380.1\|5870027_5870498_-\|ArsR-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	6.49436e-37
CP023270.1\|AVJ30381.1\|5870703_5871348_+\|lysine-transporter-LysE	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	3.90771e-41
CP023270.1\|AVJ30372.1\|5859550_5860624_+\|hypothetical-protein	gnl\|CDD\|379646	pfam14559, TPR_19, Tetratricopeptide repeat.	0.0034291
CP023270.1\|AVJ30375.1\|5861764_5862598_-\|protein-(glutamine-N5)-methyltransferase,-release-factor-specific	gnl\|CDD\|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	1.43822e-125
CP023270.1\|AVJ30371.1\|5858568_5859363_-\|metal-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	2.06559e-112
CP023270.1\|AVJ30379.1\|5867548_5870011_+\|mechanosensitive-ion-channel-protein-MscS	gnl\|CDD\|225803	COG3264, COG3264, Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane].	1.80964e-82
CP023270.1\|AVJ30376.1\|5862608_5863691_-\|peptide-chain-release-factor-1	gnl\|CDD\|234801	PRK00591, prfA, peptide chain release factor 1; Validated.	0

>CP023270.1|AVJ30377.1|5863776_5865051_-|glutamyl-tRNA-reductase
MSVAVLAFGLNHTSAPVSVRERVSMPVDLVKPALEGLRSAFGGSVREAAILSTCNRTEIYCAADGHVADQLPAWLAEHNRLDAGTLRPHLYRHHQDDAVRHAFRVASGLDSMVLGETQIVGQMKDAVRAAGEAGSLGTLLHQMFQRTFSVAKEVRSQTAIGAESVSMAAAAVRLAERVFGNLDQARTLFIGAGEMIELCATHFAAQRPRSMVVANRTAERAELLANRFSASTMKLSDLTERLSEFDVIVSCTASSLPILGLGMVERATRLRRHRPMVMIDLAVPRDIEPEVGRLDDVYLYSVDDLGRLVQTGTDARRAAVVQAEAIIETRVQGFMHWMQSREVVPVIRDLHQAAEDVRAAELERARRLLARGESPEAVLEQLAHGLTQKYLHGPLAALNRSEGDDRKQLLAWMPRLFPGRDSRR
>CP023270.1|AVJ30376.1|5862608_5863691_-|peptide-chain-release-factor-1
MKSSMRSRLEHLCHRLIEVDALLAEPETASDMDRFRKLSRERAELEPVVEAFTAFARTEEDIATAQEMLSEPDMKAMAEEEIKSGRGKLETLEAALQLLLLPRDPNDGRSVFLEIRAGTGGDESALFSGDLLRMYTRYAEQRGWRVELMSESASELGGYKEVIARIDGDGAYGRLKFESGAHRVQRVPATEAQGRIHTSACTVAIMAEADAMSEIVINPSDLRIDTFRASGAGGQHINKTDSAVRITHLPTGLVVECQDDRSQHRNKDKAMQVLAARLKDKEERERQSKEAAERKSLIGSGDRSERIRTYNYPQGRVTDHRINLTLYKLQQIMEGDLEELTGALIAEHQAEQLAALGDDI
>CP023270.1|AVJ30375.1|5861764_5862598_-|protein-(glutamine-N5)-methyltransferase,-release-factor-specific
MTAPQIKSLLLDKRLPRLEVRMLLERVLNKPRAWLLAHDTDALAPEVAAAYEALAQRRLAGEPMAYLLGHREFMGHRFRVTPDVLIPRPDTEVLVETALECIEGLTGPMVLDLGTGSGAIAVSIALARRDARVMASDVSAAALAVAAGNAWDLTAAVRFVEGSWYEAVPAGEGFDLIVSNPPYVASDDPHLEQGDVRFEPRGALTDGAGGLDDLARIVEGARAHLKPGGSLWMEHGWDQAEQVRGMLRQAGFADVHSRQDLAGIERISGGRLRVAGA
>CP023270.1|AVJ30374.1|5861211_5861538_-|monothiol-glutaredoxin,-Grx4-family
MSDVQEFIRETVTQHPVVLFMKGTAQFPQCGFSGKAIQILKGCGVKKLVTVNVLEDDEVRQGIKEFSSWPTIPQLYVSGEFIGGSDIMNEMNESGELKTLLEQSGATA
>CP023270.1|AVJ30373.1|5860643_5861204_-|3-octaprenyl-4-hydroxybenzoate-carboxy-lyase
MRRLVVGITGATGALYAVRMLQALRNVEDVETHLVVSASGVLNIKHELDVSRQDVYALADHVHSIRDVGATLASGAFQTAGMVIVPCSMRTLAAVAHGLSDNLITRAADVTLKERRRLLMMVRETPFNLAHLRNMTAVTEMGGIVFPPLPAFYHRPKSIEEMVDHTVARVLEMFDIVVPGPHWEGT
>CP023270.1|AVJ30372.1|5859550_5860624_+|hypothetical-protein
MSTTPELHPHARALLADHYAAVDADLPVLLDLLFARSAGEDWHKAGTFKHHLLGVYRTLALWNQPREVRLLGLFHSVYGNEYVDLTLFDRERERNTLRDVLGTEAEEWVSLFCAMPRTRFVQAILQGQGSGPEGLTLEGADGQVFTFTPRQVAAFTVVSAADIGEQWHSWQDEIFAGYPQQQRRDLKTNWASSLWPGPLKPPSNILSMLSHLLAPLSRMPQDTGIPIPPAFDNCRATLSPRDEAAASALYWQVITRMHPLTEMDSARHMLEAAVEHNPWVGEPRLLLAQLALTAGEFEAAEQHAAAGLAALQAWGTAWDKRIEWAGWMAWARIELQNARARKWPENLAALNGMGLVE
>CP023270.1|AVJ30371.1|5858568_5859363_-|metal-ABC-transporter-substrate-binding-protein
MRLRHSLAVFATVLGFAGTSAMAQDAELKVGVTVGPHAQIGEVVQQVAAKQGLKVKLIEFSDFIQPNAALDAKELDVNIYQHKPFLESQNKARGYKLVPVATAVVQQMGIYSKRVKSLDDLPQGGKVAIPNDPTNGARALLVLQAAKLIKLKDGVTVTASIFDIAENPKNLKFVEIEAAQLPHSLKDVDAAAVNSAYAIPAGLSPAKDALVLESKDAPFAPVVIAAREDNKNDPRIARFIKAYQSDEVKAFVAKQFPGAYTTSW
>CP023270.1|AVJ30370.1|5858016_5858556_-|cupin
MSTLTIYPDNAPDSARVLDDAAEVQRELAAIGVRFERWTAAAPLEPGAQHEAVLAAYQPQIDQLMNERGYRAVDVISLDATHPDRAALRRKFLAEHTHADDEVRFFVAGSGLFVLHAEGRVYAALCEKDDLISVPAGIPHWFDMGSSPAFTCIRLFNDPAGWTAQFTGDDIATRFPVLP
>CP023270.1|AVJ30369.1|5857097_5858060_+|LysR-family-transcriptional-regulator
MFNRRELLLLRAMYRLDTVTAAAASVNMTQPAASALLRDMETRLGFALFSRENRRLHLTSQGRALIPEVLNALAGIEAVDRLAVDIRQGALARLDVGAVAIAASSLLPPALAGVRRAHPAVAVTVRAGTALEIIEMAVDHRIDLGIIIGSPPDIDRVSSLRLAPLGLHAVMAQDHPWAKKASLTLDEVAEAGPIVLAPALPAGRATRQALEARGLPYRPIIEAAQSSAACALAAEGLGVAIVESLGAHYAERQGLVARQLLALEDPVLAVVWSRDRAMSAPAQLLQEGLAREVQTWLSRAKARDTGLKAEPESASRYRRP
>CP023270.1|AVJ30368.1|5855892_5856990_-|mandelate-racemase
MPANTIVSVTCIPLRLPFHHWSPSPLFAGRPRDKLDSALVRVQTEDGTVAWGESYCVEPRALPAIFETLIAPLACGRDADDDTLLPGMQRTLHNLGRSGPVVHALAGLDIALWDLRAKRAGVPLYALLGGKRRERVRVYASLLQYYGNAERLDAVTTRALNEGYSEIKLHERTADALAAVRRSTGPGVPIMVDTNCAWLPNEAEAAIAAMRPHDPFWIEEPLWPPEDDRALARLKQACGIPLAVGENASSATDLERVVDTQAAQYVQPSVIKLGLTAAWRIAQKCADSSVICAPQVAFFGPGYLASLHLIAAQQAEVSLERLYVELAHVPYGKRVPIENGWVNVPDGPGLGADPEAELAEGRYSA
>CP023270.1|AVJ30378.1|5865839_5867204_-|hypothetical-protein
MNKVTRESVLNAIRYLAMSGRREVSSSDVISATQGSSATVRRYLDALCAAGLLIRSGRARATRYRLTDAATIDRPGVTEPLPAPETRLHPTWSAAAVELNKKLDVPLAARDPVSYQREFVDSYVPNESWLMPKSLAEELFRSGSMKEQLPAGTYAREVLEPLLIDLSWSSSRLEGNPYTMLATEELFKQGTAGGDANAVMLLNHKAAIEFLVEMVPLQGLSTAVVRNLHAVLMQDLLADGNGLGAIRQKVVNISDTVYVPSQVPAILEEMLEAILLKARHIKNPVEAAFFLWVNLAYLQPFEDGNKRTGRLAANIPLMLYNCSPLSFLDVDPRDYARAMLGVYEYLDVTLAVDLFAWTYRRSLKKYVVVMESRGRPDPLRLRYRDSLNEAISLVVRDRRSVQDAVEVLGLNESAAPGFETMLRDDLKKLEVFNYARYRLTLSATQAWIDDGRPQ
>CP023270.1|AVJ30379.1|5867548_5870011_+|mechanosensitive-ion-channel-protein-MscS
MRARARILFCLFGLALGWAGAALGAETPAPAAQAPAAIQMAEIPLRADTDLRYAEGVLQRAATADPVAALMPPLDAIAKSADEKLYEFQPAQLRNFPIMRLESLERHWIFDVRRLARWQVEMRQATAWYASDAAELLRRRTAWQAIKDAPGASGLPAALAERIDAVIAQLAAASQALSGPLSRQVELEQRANAIEEQIKAGQRQVMEAIDYVDARLLRVDSPPLWALDWAGKTDQDTLTLLREGLDIEVRFARDYGAAGASNQRALHTLQLLLLPLLLWLARKSRNAIRTGVMSETAAGVLGRPLSTWVLLSMMGVLALEPDAPLMVQQIALVLAAVPVLRLLPPASRRHLDHWPRVITALFLAERLGFLFLANTLYYRLSTVAMAGLALAAILWLLARGRRQTYPPGSERLVRALRAVAWGAAALLCVSLGANLIGNVSLSEMLTSGIIGSGYFGLVLYAGVTVIITLLQLLLARQGISRFRLARDHAPPLVQLLIRLVSAAAVVGWAVYTMDRFRVLRSTYAFVTQVLSYTLEFGQISISLGNVLVFAISVLIAFWAARTIRIILHDEVLTRMSLPRGVGNSIASLSYYLVLLLGLGIALSAAGFQTSQLTIVFGALGVGIGFGLQGVVNNFVSGLILMFERPIQPGDVVEISGTSGQVRDIGMRATRIKTFEGADVIVPNGTLLSEKLTNWTMLDRSRRIEVSIGLAYGTDPRQVLELLDGVARQTPGVVTEPAPMVLFMGFGASTLDFSLRAWTYDFDRWIEIRSDMMARMYDALREAGIEIPFPQRDLHLRSVSEAASRTLFDARPPGSDAPHPG
>CP023270.1|AVJ30380.1|5870027_5870498_-|ArsR-family-transcriptional-regulator
MELDDFDLQILQSLQEDNQRTSQDVAQRVNLSPVSCLRRMKRLRESKVVTADVSVVDPAAVGRGITMVVLVSLESERADKLDQFKRAMQTAPEIMQCLSVTGEVDFVLTLTMRDMAEYEVFAQRHFWGNPNVKRFSTLVVMSRVKNGLTVPVTVPG
>CP023270.1|AVJ30381.1|5870703_5871348_+|lysine-transporter-LysE
MPSLQLFLLFLAADAALKLTPGPDMALTLSRGMTQGFRPAFHSVLGNVAAGFIQVPAVVLGLASVLRTFPTLFVGIKAAGGLYLGYLGIKAMIRCANAAEVSLAARPGDARDAFWQGFITNLLNPKVLLFMIAFLPQFTSPDNGPVWIQMLVLGVTMKALSLPYGSCFAYGASRIRGWVARNPWFLRAQQGILGAIMLGLAMYVLASTAMNPQP
>CP023270.1|AVJ30382.1|5871409_5872315_+|EamA-family-transporter
MTAATLNNGHNGSASTLLPTLSLIGAMASLCVGTSFAKSLFPEVGAQGTTAYRIVIGAIILLAFWRPWRFPLTRRNAAKIALYGVTLACMNLLFYMALKTLPLGIAIAIEFTGPLTLAVVLSRRAIDFVWIACALAGLILLIPTGQSVHDLDPQGIAYALGAAVCWALYIIFGKMAGNVHGGQATSLGLLAAAMVALPVGAAHAGMALLDPKLILAGVAVGILSSALPYSLEMVALRRLPQKTFGVLLSMEPAMGALAGVVVLNEHLSQTQWLAILGIIVASAGCAATAQRSRKAPIPAPD
>CP023270.1|AVJ30383.1|5872322_5872898_-|hypothetical-protein
MSLIVAARFEGFEAAKAAASRLATSGFPDWDIHTFYVNPAGEHGRFPYGGDRRSDPDAGRADMGAYLGAGGVGAVFAVFGGFVAAELSDSTAAILAAAGVGAYLGSLFGALWVTGHGTTQHGHFNPDSHAEIRQAGVMVAVRVRPQREILACRILRDAGGADVEHANGHWRNNHWEDFDPLSLPQREPGFG
>CP023270.1|AVJ30384.1|5873022_5873994_-|ABC-transporter-substrate-binding-protein
MFQGMLRMLFSAALAAAMPAASWAADYPDRPIRWLVPFSAGGGSDLATRIVARHVGETLGQPVVVENRPGAATIVAAQEAARAQPDGYTVLTAGMSTLALNPWLYNDLPYDPQQQLTPVSTLVALPIVLVAAPDSGLHTLGDVKTYLKREPPGSYASLGVGSPHHLAMELFMETVGGRATAVPYKGSPPALQDVAAGVVPLMMADLAAARPLIQAGRLRAIAVPAAKRSTQLPAVPTFAEAGGPIFEAAAWQGVVAPAGTPAPIVEQLSHAIRQALASPDVVKQLTLQGMEPAGSTPDAFRAYTRQEHERWGAVIQGKGLAAE
>CP023270.1|AVJ31243.1|5874038_5874824_-|hydroxypyruvate-isomerase
MLKFAANLSMMYTEHAFLDRYAAAAADGYAGVECMFPYEAPAAFVRERMDAAGVAQVLFNAPPGIAAQGDRGLAALPGRQAEFQAGIEQALSYATALSCSNVHVMAGVAPPDASREAMLDYYHANLDWAAREARSAGVTLLIEPINTRDIPGYFLNRQDEAHAVVQAVNAPNLKVQMDLYHCQIVEGDVTAKLREYLPTGRVGHLQIAGVPLRQEPDRGELDYGWIFGVLRELQYTGWIGCEYRPAGSTSAGLRWLGAARA
>CP023270.1|AVJ30385.1|5874905_5876936_-|TonB-dependent-receptor
MLMAPVAQAQTEGENRVQTPAQTVAPITVSANPLGLDLNSTTLPASVLEGDALIEQRNGTLGETLKNLPGVNSDTFGGGASRPVIRGQTAPRVKVLSDGSEVMDASAISPDHAVTVEPLLAERIEVLRGPATLLYGGGAIGGVVNVVDKKIPTEVPEKGIAAEAELRGATGTKERAGAVGITAGEGQFAVRVEGMKRRTSDYDVPDWPGGKLEGSYSESTQGSVGMSWITPRGYVGVAFTHLQSEYGLPGHNHEYEGCHPHGTHLHCGGHDHDHGDEGEEGHDHDHDHEHGGVPYVKLRSNRMDLRAEYQDPFAGFEKIRFRGGLTDYQHDEIEGGEVGTRFKNKGYDMRVELQHKPIAGWRGVIGLQNAYSDFSAEGEEAFLPPSKTRSTGVFLLEEYQLNDWRFELGARQDWQRVSPSGGASRSSLSGTSLSAAAIWDFAPQYSVALSLSRSQRLPNAQELYADGIHIATNTYELGNPDLTRETSHNIDLTLRKHSGDTTFSASVFHNRVKNYIYANTLDRYEDFRLIEYTQQDAEFTGVEGELRHQFTPIFSAAVFGDYVRGKLTGGDGNLPRIPAGRAGVRGNFKWQQWSGGVEYARVFAQKDIAAYEDTTPGYNMVNAVVAYRGQYGATGYEVYLRGTNLLNKLAYNHASFISTVAPLPGRSVLLGVRMTY
>CP023270.1|AVJ30386.1|5877155_5878205_-|ABC-transporter-substrate-binding-protein
MQEKNLNRRGFIKTASGLALAPALGWLPGMARAAEKEIVVGTWGGDYQNLLQQIINPIVAKQDVKVVYDTGNAVGRVTKLRAEKNSRRGSMDVALLGEVDMYDAERSGTLEPIDVKKLPNLANAIDTLKTPYSIPHIFSAMTLVYNTEKFPTPPDSLQVLLDPKWKGQVGFSDILYLYNSVFVGLGADGTTKDFEGGKRFLAKLKPNAPRIYPSNEAVAAAFKSGEIAIAVMWKARALQWKDSGLPLGFVIPKEGSVPVSFEAAVAKNSRNKDAAWAYLNAMLDPQGQIGFAEKMGYAPTVTNASLPEALKRVGFSDAEVKLLHAYDLKALTEKKADMLEFWNKEFKAG

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP023270_3	3.1\|5558868\|34\|CP023270\|CRISPRCasFinder	5558868-5558901	34	CP023270.1	1515224-1515257	1	0.971
CP023270_3	3.1\|5558868\|34\|CP023270\|CRISPRCasFinder	5558868-5558901	34	CP023270.1	3897633-3897666	1	0.971
CP023270_3	3.1\|5558868\|34\|CP023270\|CRISPRCasFinder	5558868-5558901	34	CP023270.1	5558788-5558821	1	0.971
CP023270_3	3.1\|5558868\|34\|CP023270\|CRISPRCasFinder	5558868-5558901	34	CP023270.1	1515408-1515441	2	0.941

1. spacer 3.1|5558868|34|CP023270|CRISPRCasFinder matches to position: 1515224-1515257, mismatch: 1, identity: 0.971

gccccgccgctcggccgcccgaaggcggggcagc	CRISPR spacer
gccccgccgcccggccgcccgaaggcggggcagc	Protospacer
**********.***********************

2. spacer 3.1|5558868|34|CP023270|CRISPRCasFinder matches to position: 3897633-3897666, mismatch: 1, identity: 0.971

gccccgccgctcggccgcccgaaggcggggcagc	CRISPR spacer
gccccgccgcccggccgcccgaaggcggggcagc	Protospacer
**********.***********************

3. spacer 3.1|5558868|34|CP023270|CRISPRCasFinder matches to position: 5558788-5558821, mismatch: 1, identity: 0.971

gccccgccgctcggccgcccgaaggcggggcagc	CRISPR spacer
gccccgccgcccggccgcccgaaggcggggcagc	Protospacer
**********.***********************

4. spacer 3.1|5558868|34|CP023270|CRISPRCasFinder matches to position: 1515408-1515441, mismatch: 2, identity: 0.941

gccccgccgctcggccgcccgaaggcggggcagc	CRISPR spacer
gccccgtcgcccggccgcccgaaggcggggcagc	Protospacer
******.***.***********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2841973 : 2849666

Moraxella_phage(33.33%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVJ30993.1\|2841973_2842561_+	thymidylate synthase	A0A1X9I5T8	Streptococcus_phage	2.7e-19	34.2
AVJ27920.1\|2842657_2843032_-	thioredoxin	V9SJ74	Achromobacter_phage	1.9e-10	27.8
AVJ27921.1\|2843198_2844221_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
AVJ27922.1\|2844454_2844811_+	glyoxalase/bleomycin resistance/extradiol dioxygenase family protein	NA	NA	NA	NA
AVJ27923.1\|2844868_2846161_-	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	1.3e-66	36.3
AVJ27924.1\|2846271_2847303_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	2.2e-93	52.3
AVJ27925.1\|2847368_2848007_-	glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
AVJ27926.1\|2848101_2848860_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	7.6e-67	50.8
AVJ30994.1\|2849027_2849666_+	protein-L-isoaspartate O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	1.3e-30	47.4

DBSCAN-SWA_2

3106622 : 3170513

Leptospira_phage(25.0%)

integrase,transposase

attL 3125087:3125103|attR 3183779:3183795

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVJ28113.1\|3106622_3107741_-\|integrase	integrase	NA	NA	NA	NA
AVJ28114.1\|3107953_3109681_+	pyruvate oxidase	E5ERI2	Ostreococcus_lucimarinus_virus	1.7e-21	24.6
AVJ28115.1\|3110022_3111075_+	hypothetical protein	NA	NA	NA	NA
AVJ28116.1\|3111125_3111794_-	DNA-binding response regulator	NA	NA	NA	NA
AVJ28117.1\|3112132_3115402_-	hybrid sensor histidine kinase/response regulator	Q8QKV7	Ectocarpus_siliculosus_virus	1.2e-36	28.0
AVJ28118.1\|3115411_3116629_-	hypothetical protein	NA	NA	NA	NA
AVJ31014.1\|3116625_3119379_-	hybrid sensor histidine kinase/response regulator	A0A1V0SGX0	Hokovirus	7.3e-35	36.9
AVJ28119.1\|3119579_3120347_+	hypothetical protein	NA	NA	NA	NA
AVJ28120.1\|3120398_3120755_+	hypothetical protein	NA	NA	NA	NA
AVJ28121.1\|3120797_3120986_-	hypothetical protein	NA	NA	NA	NA
AVJ31015.1\|3121235_3122312_+	hypothetical protein	NA	NA	NA	NA
AVJ28122.1\|3122884_3123697_+	RNA-binding protein	NA	NA	NA	NA
AVJ31016.1\|3123969_3124911_+	LD-carboxypeptidase	NA	NA	NA	NA
AVJ28123.1\|3125046_3125391_+	transcriptional regulator	NA	NA	NA	NA
3125087:3125103	attL	NA	NA	NA	NA
AVJ31017.1\|3125404_3126715_+	protein kinase	NA	NA	NA	NA
AVJ28124.1\|3126722_3127187_-	Rrf2 family transcriptional regulator	NA	NA	NA	NA
AVJ28125.1\|3127274_3128159_-	SAM-dependent methyltransferase	NA	NA	NA	NA
AVJ31018.1\|3128200_3129496_-	amino acid permease	NA	NA	NA	NA
AVJ28126.1\|3130094_3130481_+	hypothetical protein	NA	NA	NA	NA
AVJ28127.1\|3130494_3130980_+	DUF2214 domain-containing protein	NA	NA	NA	NA
AVJ28128.1\|3130988_3131924_-	gluconolactonase	NA	NA	NA	NA
AVJ28129.1\|3132092_3133754_-	arylsulfatase	NA	NA	NA	NA
AVJ28130.1\|3134069_3135392_+	peptidylprolyl isomerase	NA	NA	NA	NA
AVJ28131.1\|3135556_3136057_+	RNA polymerase subunit sigma	NA	NA	NA	NA
AVJ28132.1\|3136061_3137042_+	iron dicitrate transport regulator FecR	NA	NA	NA	NA
AVJ28133.1\|3137153_3139550_+	TonB-dependent siderophore receptor	NA	NA	NA	NA
AVJ28134.1\|3139549_3140692_+	hypothetical protein	NA	NA	NA	NA
AVJ28135.1\|3140986_3141418_-	arsenate reductase (glutaredoxin)	A0A2H4J8T1	uncultured_Caudovirales_phage	9.6e-51	70.7
AVJ28136.1\|3141475_3142555_-	arsenical-resistance protein	NA	NA	NA	NA
AVJ28137.1\|3142667_3142994_-	transcriptional regulator	NA	NA	NA	NA
AVJ28138.1\|3143071_3143971_-	LysR family transcriptional regulator	NA	NA	NA	NA
AVJ28139.1\|3143942_3144197_+	hypothetical protein	NA	NA	NA	NA
AVJ28140.1\|3144251_3145037_+	3-oxoacyl-ACP reductase	NA	NA	NA	NA
AVJ31019.1\|3145079_3146015_+	dihydrodipicolinate synthase family protein	NA	NA	NA	NA
AVJ28141.1\|3146011_3146890_-	LysR family transcriptional regulator	NA	NA	NA	NA
AVJ28142.1\|3147029_3148226_+	aspartate aminotransferase	NA	NA	NA	NA
AVJ28143.1\|3148305_3149010_+	ribonuclease activity regulator RraA	NA	NA	NA	NA
AVJ28144.1\|3149080_3149806_-	GMP synthase	NA	NA	NA	NA
AVJ28145.1\|3150046_3151270_+\|integrase	integrase	NA	NA	NA	NA
AVJ28146.1\|3151270_3152812_+\|integrase	integrase	NA	NA	NA	NA
AVJ28147.1\|3152808_3153174_+	hypothetical protein	NA	NA	NA	NA
AVJ31020.1\|3153282_3154800_+\|transposase	IS21 family transposase	A0A2L1IVA1	Escherichia_phage	3.0e-14	27.5
AVJ28148.1\|3154789_3155581_+	ATP-binding protein	A0A059NT77	Lactococcus_phage	6.3e-32	36.3
AVJ28149.1\|3156056_3156527_+	hypothetical protein	NA	NA	NA	NA
AVJ28150.1\|3157067_3159143_-	ATP-binding protein	NA	NA	NA	NA
AVJ28151.1\|3159139_3160501_-	fibronectin-binding protein (FBP)	NA	NA	NA	NA
AVJ28152.1\|3160837_3163582_+	hypothetical protein	NA	NA	NA	NA
AVJ28153.1\|3164642_3165763_-\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	1.8e-56	44.2
AVJ28154.1\|3165846_3166362_+	hypothetical protein	NA	NA	NA	NA
AVJ28155.1\|3166455_3167130_-	hypothetical protein	NA	NA	NA	NA
AVJ28156.1\|3167126_3167687_-	hypothetical protein	NA	NA	NA	NA
AVJ28157.1\|3167695_3168421_-	hypothetical protein	NA	NA	NA	NA
AVJ28158.1\|3168236_3169322_-	hypothetical protein	NA	NA	NA	NA
AVJ28159.1\|3169393_3170513_+\|transposase	IS3 family transposase	S5WIU1	Leptospira_phage	1.8e-56	44.2
3183779:3183795	attR	NA	NA	NA	NA

DBSCAN-SWA_3

5555988 : 5626245

Burkholderia_phage(25.93%)

tRNA,tail,portal,head,terminase,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVJ31224.1\|5555988_5556702_+\|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
AVJ30109.1\|5556701_5557643_+	prolyl aminopeptidase	NA	NA	NA	NA
AVJ30110.1\|5557654_5557855_+	thiamine biosynthesis protein ThiS	NA	NA	NA	NA
AVJ30111.1\|5558157_5558604_+	peptidoglycan-binding protein LysM	G3MBQ1	Bacillus_virus	1.2e-06	53.6
AVJ30112.1\|5558948_5560355_-	signal recognition particle protein	NA	NA	NA	NA
AVJ31225.1\|5560554_5561304_+	hypothetical protein	NA	NA	NA	NA
AVJ30113.1\|5561305_5561572_+	hypothetical protein	NA	NA	NA	NA
AVJ30114.1\|5561673_5562252_+	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD	A0A1W6DX33	Sphingobium_phage	1.0e-07	57.4
AVJ30115.1\|5562270_5562894_+	glutathione S-transferase	NA	NA	NA	NA
AVJ30116.1\|5563071_5565261_+	hybrid sensor histidine kinase/response regulator	W8CYF6	Bacillus_phage	3.9e-23	29.5
AVJ31226.1\|5565542_5568128_+	type VI secretion system tip protein VgrG	A0A2H4JCD4	uncultured_Caudovirales_phage	3.1e-35	33.0
AVJ30117.1\|5568551_5568833_-	hypothetical protein	NA	NA	NA	NA
AVJ30118.1\|5569372_5570647_+	hypothetical protein	NA	NA	NA	NA
AVJ30119.1\|5570919_5572053_+	hypothetical protein	NA	NA	NA	NA
AVJ30120.1\|5572049_5573228_+	hypothetical protein	NA	NA	NA	NA
AVJ30121.1\|5573317_5574646_+	hypothetical protein	NA	NA	NA	NA
AVJ30122.1\|5574546_5575821_+	hypothetical protein	NA	NA	NA	NA
AVJ30123.1\|5575910_5577239_+	hypothetical protein	NA	NA	NA	NA
AVJ30124.1\|5577139_5578414_+	hypothetical protein	NA	NA	NA	NA
AVJ30125.1\|5578430_5578721_+	hypothetical protein	NA	NA	NA	NA
AVJ31227.1\|5578724_5579546_-	transcriptional regulator	NA	NA	NA	NA
AVJ30126.1\|5579823_5580831_+	2-dehydro-3-deoxygalactonokinase	NA	NA	NA	NA
AVJ30127.1\|5580840_5581494_+	2-dehydro-3-deoxy-6-phosphogalactonate aldolase	NA	NA	NA	NA
AVJ30128.1\|5581490_5582639_+	galactonate dehydratase	Q6A202	Oenococcus_phage	5.7e-58	36.7
AVJ30129.1\|5582665_5583976_+	MFS transporter	NA	NA	NA	NA
AVJ30130.1\|5584327_5584657_+	addiction module protein	A0A141GEX6	Brucella_phage	7.7e-16	44.4
AVJ30131.1\|5584653_5584962_+	addiction module antidote protein	NA	NA	NA	NA
AVJ31228.1\|5584983_5586621_-	microcin ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	1.0e-12	27.9
AVJ30132.1\|5586637_5587534_-	peptide ABC transporter permease	NA	NA	NA	NA
AVJ30133.1\|5587544_5588486_-	peptide ABC transporter	NA	NA	NA	NA
AVJ30134.1\|5588489_5590094_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
AVJ30135.1\|5590164_5591604_-	N-ethylammeline chlorohydrolase	NA	NA	NA	NA
AVJ30136.1\|5591644_5593093_-	dihydropyrimidinase	NA	NA	NA	NA
AVJ31229.1\|5593411_5594092_+	GntR family transcriptional regulator	NA	NA	NA	NA
AVJ30137.1\|5594168_5595368_-	MFS transporter	NA	NA	NA	NA
AVJ30138.1\|5595560_5596826_-	phosphatidylinositol kinase	NA	NA	NA	NA
AVJ30139.1\|5596822_5597074_-	transcriptional regulator	NA	NA	NA	NA
AVJ30140.1\|5597314_5599213_-	molecular chaperone HtpG	A0A1B1ISV4	uncultured_Mediterranean_phage	1.4e-117	37.0
AVJ30141.1\|5599419_5600811_+	xanthine permease XanP	H9YQ34	environmental_Halophage	6.3e-27	52.4
AVJ30142.1\|5601167_5601569_-	hypothetical protein	NA	NA	NA	NA
AVJ30143.1\|5602990_5603209_+	hypothetical protein	NA	NA	NA	NA
AVJ30144.1\|5603247_5603763_-	hypothetical protein	NA	NA	NA	NA
AVJ30145.1\|5604677_5604944_-	hypothetical protein	NA	NA	NA	NA
AVJ30146.1\|5604927_5605500_-	hypothetical protein	C8ZKE7	Pseudomonas_phage	2.5e-30	48.7
AVJ30147.1\|5605472_5605916_-	hypothetical protein	Q6TM82	Pseudomonas_phage	2.2e-10	34.4
AVJ30148.1\|5606039_5606723_-	hypothetical protein	NA	NA	NA	NA
AVJ30149.1\|5607005_5610170_-	host specificity protein J	A4JX16	Burkholderia_virus	6.4e-269	45.4
AVJ30150.1\|5610166_5610781_-\|tail	phage tail protein	C7BGD3	Burkholderia_phage	3.7e-56	57.4
AVJ30151.1\|5610777_5611557_-	hydrolase Nlp/P60	Q8W6T2	Burkholderia_virus	8.1e-64	49.0
AVJ30152.1\|5611559_5612288_-\|tail	phage minor tail protein L	A0A2R3UA90	Siphoviridae_environmental_samples	1.5e-64	49.0
AVJ30153.1\|5612292_5612730_-	hypothetical protein	NA	NA	NA	NA
AVJ30154.1\|5612730_5614041_-	hypothetical protein	A0A0B5A596	Achromobacter_phage	2.8e-24	40.8
AVJ30155.1\|5614142_5614478_-\|tail	phage tail protein	K7PHJ6	Enterobacteria_phage	4.1e-25	46.8
AVJ30156.1\|5614477_5617285_-\|tail	phage tail tape measure protein	A0A2H4J107	uncultured_Caudovirales_phage	1.5e-99	34.6
AVJ30157.1\|5617288_5617594_-	hypothetical protein	A0A2H4JBP7	uncultured_Caudovirales_phage	1.9e-08	38.4
AVJ30158.1\|5617602_5617914_-	hypothetical protein	NA	NA	NA	NA
AVJ30159.1\|5617916_5618570_-\|tail	phage tail protein	A0A1B0VMG2	Pseudomonas_phage	4.4e-23	31.1
AVJ30160.1\|5618632_5618992_-	hypothetical protein	NA	NA	NA	NA
AVJ30161.1\|5618981_5619509_-	hypothetical protein	I7GSL4	Xanthomonas_virus	8.5e-17	39.9
AVJ30162.1\|5619501_5619855_-\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
AVJ30163.1\|5619851_5620328_-	hypothetical protein	NA	NA	NA	NA
AVJ30164.1\|5620330_5620585_-	hypothetical protein	Q3HQT1	Burkholderia_phage	1.7e-07	59.6
AVJ30165.1\|5620636_5621881_-\|capsid	phage major capsid protein	Q3HQT0	Burkholderia_phage	1.1e-150	66.6
AVJ30166.1\|5621883_5622723_-	peptidase	Q3HQS9	Burkholderia_phage	3.5e-105	72.1
AVJ30167.1\|5622700_5623987_-\|portal	phage portal protein	Q3HQS8	Burkholderia_phage	4.3e-131	59.7
AVJ30168.1\|5623995_5625702_-\|terminase	terminase	Q3HQS7	Burkholderia_phage	8.3e-231	68.1
AVJ30169.1\|5625705_5626245_-\|terminase	terminase	Q3HQS6	Burkholderia_phage	7.4e-16	39.0

Anti-CRISPR protein detection

Acr_ID: CP023270.1|AVJ30125.1|5578430_5578721_+|hypothetical-protein

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Acr ID

Acr position

Acr size

Homology with known anti

Neighbor HTH/AcRanker

Neighbor Aca

In prophage

Protospacer in prophage

CP023270.1|AVJ30125.1|5578430_5578721_+|hypothetical-protein

5578430_5578721_+

96 aa aa

5555988-5626245

yes

CRISPR ID	CRISPR type	Spacer info	Spacer location	Spacer length	Protospacer location	Mismatch
CP023270_3	Orphan	3.1\|5558868\|34\|CP023270\|CRISPRCasFinder	5558868-5558901	34	5558788-5558821	1

1. spacer 3.1|5558868|34|CP023270|CRISPRCasFinder matches to CP023270 position: 5558788-5558821, mismatch: 1

gccccgccgctcggccgcccgaaggcggggcagc	CRISPR spacer
gccccgccgcccggccgcccgaaggcggggcagc	Protospacer
**********.***********************

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP023270

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

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