CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP021325	Listeria monocytogenes strain NH1 chromosome, complete genome	2 crisprs	DinG,cas3,WYL,casR,DEDDh,csa3	0	1	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP021325_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP021325_2

536868-537156

Orphan

I-A

Consensus_repeat	Method
GTTTTAGTTACTTATTGTGAAATGTAAAT	PILER-CR
GTTTTAGTTACTTATTGTGAAATGTAAAT	CRISPRCasFinder
GTTTTAGTTACTTATTGTGAAATGTAAAT	CRT

4 spacers

The CRISPR arrays of CP021325_2

>merge|CP021325|2|536868-537156|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGTTACTTATTGTGAAATGTAAATCGATAAAAAAGATATTAGTAATTTATTTGCAATTTAGTTTTAGTTACTTATTGTGAAATGTAAATTGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGCGTTTTAGTTACTTATTGTGAAATGTAAATGCGATTTTTGTCAAAGGGACAGCGATGGGTTACAAGTTTTAGTTACTTATTGTGAAATGTAAATTTACCACCAAAGTCCCTACACTCAATACCACCAAAGCGTTTTAGTTACTTATTGTGAAATATAAAT

>CP021325|2|1|536868-537156|PILER-CR
GTTTTAGTTACTTATTGTGAAATGTAAAT	CGATAAAAAAGATATTAGTAATTTATTTGCAATTTA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTACCACCAAAGTCCCTACACTCAATACCACCAAAGC
GTTTTAGTTACTTATTGTGAAATATAAAT

>CP021325|2|2|536868-537156|CRISPRCasFinder
GTTTTAGTTACTTATTGTGAAATGTAAAT	CGATAAAAAAGATATTAGTAATTTATTTGCAATTTA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTACCACCAAAGTCCCTACACTCAATACCACCAAAGC
GTTTTAGTTACTTATTGTGAAATATAAAT

>CP021325|2|1|536868-537156|CRT
GTTTTAGTTACTTATTGTGAAATGTAAAT	CGATAAAAAAGATATTAGTAATTTATTTGCAATTTA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TGCTCTCTTTTGTGTAAAGCACATCAAGCATGTAGC
GTTTTAGTTACTTATTGTGAAATGTAAAT	GCGATTTTTGTCAAAGGGACAGCGATGGGTTACAA
GTTTTAGTTACTTATTGTGAAATGTAAAT	TTACCACCAAAGTCCCTACACTCAATACCACCAAAGC
GTTTTAGTTACTTATTGTGAAATATAAAT

Protein	Signature genes	Signature genes Name	Protein_function
CP021325.1\|AVK44066.1\|538806_539166_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|131113
CP021325.1\|AVK44071.1\|543959_544775_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
CP021325.1\|AVK44065.1\|538101_538782_+\|GMP-synthase	unknown	unknown	gnl\|CDD\|153212
CP021325.1\|AVK44057.1\|531373_531841_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|238129
CP021325.1\|AVK44063.1\|535694_536630_+\|ribose-phosphate-pyrophosphokinase-2	unknown	unknown	gnl\|CDD\|234929
CP021325.1\|AVK44064.1\|537415_537994_+\|hypothetical-protein	unknown	unknown	unknown
CP021325.1\|AVK44055.1\|528679_530740_+\|PTS-sugar-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|226234
CP021325.1\|AVK44070.1\|542408_543839_-\|capsule-biosynthesis-protein-CapA	unknown	unknown	gnl\|CDD\|225399
CP021325.1\|AVK44069.1\|541930_542362_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
CP021325.1\|AVK44059.1\|532266_532917_+\|ribulose-phosphate-3-epimerase	unknown	unknown	gnl\|CDD\|223114
CP021325.1\|AVK44073.1\|545570_546986_+\|lincomycin-resistance-protein-LmrB	unknown	unknown	gnl\|CDD\|129794
CP021325.1\|AVK44061.1\|533975_534269_+\|PTS-galactitol-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|99908
CP021325.1\|AVK44072.1\|545055_545424_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226282
CP021325.1\|AVK44067.1\|539172_539631_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|378956
CP021325.1\|AVK44068.1\|540012_541830_+\|cell-surface-protein	unknown	unknown	gnl\|CDD\|380190
CP021325.1\|AVK44054.1\|527920_528571_+\|transaldolase	unknown	unknown	gnl\|CDD\|223254
CP021325.1\|AVK44058.1\|531857_532256_+\|hypothetical-protein	unknown	unknown	unknown
CP021325.1\|AVK44062.1\|534283_535555_+\|PTS-galactitol-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226298
CP021325.1\|AVK44056.1\|530743_531346_+\|phosphosugar-isomerase	unknown	unknown	gnl\|CDD\|223865
CP021325.1\|AVK44060.1\|532913_533960_+\|galactitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|176198

Protein	Function_ID	Function_description	E-value
CP021325.1\|AVK44066.1\|538806_539166_-\|hypothetical-protein	gnl\|CDD\|131113	TIGR02058, lin0512_fam, conserved hypothetical protein. This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N-terminus. [Hypothetical proteins, Conserved].	5.62162e-67
CP021325.1\|AVK44065.1\|538101_538782_+\|GMP-synthase	gnl\|CDD\|153212	cd01741, GATase1_1, Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. Glutamine amidotransferases (GATase) includes the triad family of amidotransferases which have a conserved Cys-His-Glu catalytic triad in the glutaminase active site. In this subgroup this triad is conserved. GATase activity can be found in a range of biosynthetic enzymes, including: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase , anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. Glutamine amidotransferase (GATase) domains can occur either as single polypeptides, as in glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.	9.06055e-60
CP021325.1\|AVK44057.1\|531373_531841_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|238129	cd00211, PTS_IIA_fru, PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	2.76446e-37
CP021325.1\|AVK44063.1\|535694_536630_+\|ribose-phosphate-pyrophosphokinase-2	gnl\|CDD\|234929	PRK01259, PRK01259, ribose-phosphate diphosphokinase.	1.26262e-153
CP021325.1\|AVK44069.1\|541930_542362_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	4.03126e-27
CP021325.1\|AVK44055.1\|528679_530740_+\|PTS-sugar-transporter-subunit-IIA	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	5.36772e-80
CP021325.1\|AVK44070.1\|542408_543839_-\|capsule-biosynthesis-protein-CapA	gnl\|CDD\|225399	COG2843, PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane].	2.95496e-100
CP021325.1\|AVK44071.1\|543959_544775_-\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	5.01016e-50
CP021325.1\|AVK44059.1\|532266_532917_+\|ribulose-phosphate-3-epimerase	gnl\|CDD\|223114	COG0036, Rpe, Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism].	4.74405e-108
CP021325.1\|AVK44061.1\|533975_534269_+\|PTS-galactitol-transporter-subunit-IIB	gnl\|CDD\|99908	cd05566, PTS_IIB_galactitol, PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain that are expressed on three distinct polypeptide chains, in contrast to other PTS sugar transporters. The three genes encoding these subunits (gatA, gatB, and gatC) comprise the gatCBA operon. Galactitol PTS permease takes up exogenous galactitol, releasing the phosphate ester into the cytoplasm in preparation for oxidation and further metabolism via a modified glycolytic pathway called the tagatose-6-phosphate glycolytic pathway. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include galactitol, chitobiose/lichenan, ascorbate, lactose, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.	3.06007e-27
CP021325.1\|AVK44072.1\|545055_545424_-\|hypothetical-protein	gnl\|CDD\|226282	COG3759, COG3759, Predicted membrane protein [Function unknown].	2.33548e-41
CP021325.1\|AVK44067.1\|539172_539631_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	9.15558e-13
CP021325.1\|AVK44068.1\|540012_541830_+\|cell-surface-protein	gnl\|CDD\|380190	NF033186, internalin_K, class 1 internalin InlK. Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.	1.81836e-118
CP021325.1\|AVK44054.1\|527920_528571_+\|transaldolase	gnl\|CDD\|223254	COG0176, MipB, Transaldolase [Carbohydrate transport and metabolism].	5.85703e-62
CP021325.1\|AVK44062.1\|534283_535555_+\|PTS-galactitol-transporter-subunit-IIC	gnl\|CDD\|226298	COG3775, GatC, Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism].	7.01085e-178
CP021325.1\|AVK44073.1\|545570_546986_+\|lincomycin-resistance-protein-LmrB	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	3.18163e-80
CP021325.1\|AVK44056.1\|530743_531346_+\|phosphosugar-isomerase	gnl\|CDD\|223865	COG0794, GutQ, Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane].	1.15952e-75
CP021325.1\|AVK44060.1\|532913_533960_+\|galactitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|176198	cd08236, sugar_DH, NAD(P)-dependent sugar dehydrogenases. This group contains proteins identified as sorbitol dehydrogenases and other sugar dehydrogenases of the medium-chain dehydrogenase/reductase family (MDR), which includes zinc-dependent alcohol dehydrogenase and related proteins. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Related proteins include threonine dehydrogenase, formaldehyde dehydrogenase, and butanediol dehydrogenase. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Horse liver alcohol dehydrogenase is a dimeric enzyme and each subunit has two domains. The NAD binding domain is in a Rossmann fold and the catalytic domain contains a zinc ion to which substrates bind. There is a cleft between the domains that closes upon formation of the ternary complex.	0

>CP021325.1|AVK44063.1|535694_536630_+|ribose-phosphate-pyrophosphokinase-2
MAGKMKLFSVTSERPLATKIADYLDIPLCEVELQKFSDGEVKINIEESIRGTNAYVVQSMNSNVNERLMELLIMVDALKRASVHSINIIMPYYGYARQDRKARSREPITAKLMANLIQRAGANRLITVDLHAAQIQGFFNIPIDHLSAIPLIGDYLIENYGEKDVVVVAPDHSGVVRARRIADRLNAPIAILNRKPRPHEDEIMSVIGDVKGKVAIVVDDIIDTGVRATTSADILLEKGAVEVIACATHSVMAGNATERLQNSNIKEVITSDSIDLPEDKQFDKLTTISIGRILGRAIEGVQENRSLHPLF
>CP021325.1|AVK44062.1|534283_535555_+|PTS-galactitol-transporter-subunit-IIC
MDIILDFFKYIIGLGVTVMMPIIITILGVIFRKKISVAFKAGLTVGVGFVGLGVITSLMLTTITPVTKALVENYNFKLTATDIGWGVGSSLAWGTEVVPFVFVAIIATNILMIAFKWTKTMDVDIWNYWQPLFIASALYLTTGSMIIAVLSSIINMAIIFKIADWTQKDVEDVLGLEGISLPQIQTTGWALVGYPMNWLLGKIPGVRKINWSTEKVQSRLGIFGEPMLMGLIIGGGLAAIAQMPLSQVLQTGVTIAASLVLIPRMVSLLMDGLTVISEAAHEFMEKRFPGRELFIGLDSAVGIGHPFVLSLGLLMIPITLILAFILPGNKVLPLADLTALPFYMIFAIVPSKGNLFRGIFTGIVIVIITLYLSGAAAPLMTELAGQIGYNIPKDAVEVTSLAVGTQWYTWIVYYGLHWFGGIL
>CP021325.1|AVK44061.1|533975_534269_+|PTS-galactitol-transporter-subunit-IIB
MKKKRIYVCCGTGIATSTVISKKVRAVLDEKRIPYEISQCTVQEVASKVSTSKPDIIVSSTTVTGDVGDVPVVIGRSFLTGLKKQETIDEILAILQD
>CP021325.1|AVK44060.1|532913_533960_+|galactitol-1-phosphate-5-dehydrogenase
MKALKLYGKRDLRYEEADMPTIEEPDDVILKVKTVGICGSDISRYSKLGPYVPGMVWGHEFSGEVIEVGSEVTDIEIGDRAAGCPALYCGECEYCKKGEFARCRKLTVIGARHPGAYAEYIKLPAENVVKIPNELDYEAAALVEPSAVVVHGFYHTKLQAGDDVVVVGSGNIGLLAIQWAKVFGARRVIAIDVDDKKLALAKEVGADVVINSLKEDPLEVVAAHTDGLNADLVVEAAGSPITSAQVFAYAKKGGGVVFLGIPYADVTIERFYFEKIVRSELTVWGSWNAISAPFPGKEWQTTIHFLANKQINIEPMITHRLSLAEGPEVFERIYERNEFFGKVLFFPE
>CP021325.1|AVK44059.1|532266_532917_+|ribulose-phosphate-3-epimerase
MAKIVPSVFGADIGRINEQLQVLEKNDIDLLHVDMMDGSFVPNIAFGPDQIKMMKKGTKLQFDVHMMVYEPDRYIPRLVEAGAHMITVHQEATTHLHRTIQLIKSYGVRAGVVLNPGTPPSTLEYVLDDIDCILLMTVNPGLGGQKFFQSSLEKIRKTKAYIGNRPIQIEVDGGVNDELAKECTLAGADLIVVGSYLFEGDIEANLEKLAKGVLTE
>CP021325.1|AVK44058.1|531857_532256_+|hypothetical-protein
MGSFFASFVDWLIGSPGRFVVNLIEDNMLIFMVVVMIYATTILYAKWTLAYYLPKKMSQLAEMKTWELDELYAAWQTEKKALPWYILVPSRNEFWVKSARNAPESTKLLHFSQQKLKLSDKEKLQKIIEIQS
>CP021325.1|AVK44057.1|531373_531841_+|PTS-sugar-transporter-subunit-IIA
MDVLEYFKEEMVRFSNEQNKEKLLAEMAEQLCEVGAVKPSYKDAVIKREKVFPTGLLTAHAGVAIPHTDSEHVIRPVVAVRILKKPVSFIEMASDNEAIDVRIVFMMALRSADEQLDMLQTLIQLIQDEEVMTTLLKAQETGDVLSAIEHFSKNN
>CP021325.1|AVK44056.1|530743_531346_+|phosphosugar-isomerase
MDKQAILNNIHQTWQEEANAISRLPEVTSEEALVKTVEKIAECTGKIVVAGCGTSGVAAKKLVHSFNCIERPAVFLTPSDAVHGTLGVLQKEDILILISKGGNTGELLNLIPACKTKGSTLIGVTENPDSVIAKEADIFFPVSVSKEPDPFNMLATASTMAVIASFDAVIVCLMTYMNYTKEQFSVIHPGGAVGNKLLNK
>CP021325.1|AVK44055.1|528679_530740_+|PTS-sugar-transporter-subunit-IIA
MYLDNRSKTLFQEVIKNPNITNKQLEVKYKLSRYQISYSFQKVNEWLKWKNYPEVKRSKNGRFILEPELTALFSEKETRDPSVEYLPSENERANLILLMLLTSKEELSLAHFTTKIQVSKNTILRDLKVAQKLLPKETTVTYSRASGYQLAGSEWELRKVLTQVVSSVKEMFRGEHYFLSYSGIEKVQLMEIRRTLEEAEAMMQIKFTYEQIELLPYLLSVMFLRIRDRRLIDTAFHIDEKSLSDTREYHITDILLEKTGPVPEQERLFITLQLLTTNIFSGEILTEKLTEDLEKVVLTCLDLFEKKALVSLKNKHILIEKLLLHLKPAYYRIKYQMNLEDTLYEKFNQEFEALNFIVKEAFDPLAKFIGREIPAGEIFFISLFIGSDMIPQNDIYHKQKRAIVLCPSGVTFSKIMENILVKLFPEIHFYPTISVREYAFFKAEVDIVFSSIPLKDGENVFVVQPFMNDIEKTQLRQHVLQNLFGMGNQLTSIDKIMEVVERNADIKDPNAIRDGIIDILSANIATDENKRVKKVYLHDLITEDNIMICEDVKNYQEAIRLASQPLLLQQAITANYVKTMIDNHKFHDPYIIIGEDIAIPHAMPNAGVNRLAMSLLVVKNGVYFSETEQVHFVIVIAPVDKEQHIEALYQIVHLAENHQILDDLLENVTKEKIMQTINQLVIREDE
>CP021325.1|AVK44054.1|527920_528571_+|transaldolase
MHLDSANLDDVKKIQASSIFKGITTNPTILVKEKCNRQTAINRILELTDKQVFVQTVGFTYEEILADARMLLTMFGKDKIAIKIPAHEAGTNVIDTLKKEDKTIQILGTAIYSADQAITAALAGADFVAPYVNRMSAANIDPFKEITQMRHFFDKKALKTQIMAASFKHSGQVMQAYESGADTVTIPYEIYSQMTNKVLAVEAIRVFNEDAVLYEK
>CP021325.1|AVK44064.1|537415_537994_+|hypothetical-protein
MKKILVPILLLATILASCSSPNEKITKDTKISKTITIRADYKVPKDIKELEDDSANIVKVKFLQNKTIGKDGSTISEIEILTSYKGNLEKGSKVDISEPWYLSDGKYVAVENYIALDKEQEYTIFLGEKDKDTYPLSSLGYGKFGGSLKEDQAVLADFNILGEVQKFDFISENTEEVKNYQLIKEQVAGKYK
>CP021325.1|AVK44065.1|538101_538782_+|GMP-synthase
MIIDVLQHVPHEGPGLIANWARENQHQLKIHSLFEENAHVPNDSDFLIVLGGPMGINDTAEFPWLKDERKLIKRLSEQHKPVFGVCLGAQQIAATFGSEITVNKEKEVGWFPVKRTSDKLLFFPKSLNVFHWHQDTFALPTGSTRLFASEGCLNQAFLYGENIIGLQFHFEMEKAGIETILRIDEAFITPGKYVQSVEVMREKDVPEDNKQMLEAILDYLINPKTI
>CP021325.1|AVK44066.1|538806_539166_-|hypothetical-protein
MEQILFIQTGFGVDVHGQNITKAAERAVRNAIFTNSMPGIQGLLPDGDLQNMVVNIKLALPCDADQLDEDTIRAIIPYGTVTIEKMAGGMMTTSGIFLEDKEDKNDLMYIVNASVETGY
>CP021325.1|AVK44067.1|539172_539631_-|MarR-family-transcriptional-regulator
MNNEQNMNQQIALFYFGYKAFTETADLIIAKHSLKRLHHRILFFTARMPGLTINELLTFLEISKQALHQPLAELKERELLTIEQGRRDKRQRCIFLTSAGKELENELGAAQRKQMSEIFTNSADTDGMHFTEVMEGYAKNRPGAAFIKDFKE
>CP021325.1|AVK44068.1|540012_541830_+|cell-surface-protein
MKKALKLFLATICMFIMIYPSTAAHAEETNIVNIPDANLKTYLNGLLKQASDAPITKTQMNTIQTVTLSGSTYTDLTGLEEAGNLVTLSLNNTNIQTLEPIKNQTSLTYLTVGGDNVKDSLFVDLNGLVNLQSLSINGSEVTHNVFKTFNKLPKLTYLYAQNSMKITDISALASLPALTTLFLQFDGIDDFRPLNDFESFKNGNLKALAAFGQNTGRTNPRITLKSGKLDYNETNQTLYLPFSMMPKPLTSFDGTVAPFSKSTSASNTYLGFNDVALPSSRLSITDDGITVSGVTKEEFDNLDEIEYNARYDFPTGSYPTPPSMTSYTISSGTYDQYFDISHTLDLTADESFDYNQYDTTSEEQFLKDVHAETDDGTAVKSDFDQVVKLDVPGEYTVTLNAENAAGLKATPVTVKVTVHEKPVITSDSQISYKKETTKSVDEFLKEIHGSVTGNAVLTSDFDKVVDLNTPGEYTVTLNAINDRGQKADPVTVVVTVTTSDSGHVDPVPPTPQEETDQTIIPEPQSETTEDSVKEDQAKDGQAKSEEKADKTSLTTKENKVEKSEKTNQPKTKALPQTGDTNKTALPIAGVMLSLAALLIFRKSKS
>CP021325.1|AVK44069.1|541930_542362_+|universal-stress-protein
MEKYHRILVAVDGSEPAKLAFEKGLELALKLDGVLGIASIVDLRAFSPNVSYDGSLEEKAELELKTSVNEYAEKARTAGVKQVETFVAKGNPKILLSTDIPAEFQADLIICGATGMNRVEKLVLGSVSSYIMAHAICDTLIAR
>CP021325.1|AVK44070.1|542408_543839_-|capsule-biosynthesis-protein-CapA
MKKLTYVIITGLVLVFIAGAFWITNSTNQSDQKATQTEPIKKISPANVKTISSEAKKTLNSLASSGADKASISDLKQLIKELKSYPTEKNDSGVYLQNLTACLEAVKSYTTGKADEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTIINAESAFTNATKAENKMWRIKSDPAHVAFLPASGVDAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNADAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDVKKYKKEDTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
>CP021325.1|AVK44071.1|543959_544775_-|histidine-phosphatase-family-protein
MKKNIFKLLMALCAVLLIAGCGNSTSADKKETKETKEDGTVTFYVVRHGKTMLNTTDRVQGWSDAVLTPAGEEVVKSAGKGLKDVDFSAAYSSDSGRAIQTANLILKESDKSADKEVQTDPRFREFNFGSYEGDLNENMWTDIAKSQGKTLEEWQKAGLSPKDFANSVAALDKTRVKEGENWPAEDYATIQARLKEGLTDVAKKESKNGDSNVLLVSHGLSIGALLDTIEPGYKLPAEGIKNASVTKITYKDGKFTIGDVNDLSYVEKGSK
>CP021325.1|AVK44072.1|545055_545424_-|hypothetical-protein
MAILAFILTFIVMIEHIYIMILEMFFANTKLAAKTFGVEKELLANKKVQTLFANQGLYNGFLAAGLVWGLFFAGAGFAETVQIFFLSCVVVAALFGGATSSKGILVKQGLPAVLALVAVLLV
>CP021325.1|AVK44073.1|545570_546986_+|lincomycin-resistance-protein-LmrB
MQQEATGGQKIRPIPIIASFLMAGFIGLFSETALNMALSDLIQVFDISSATVQWLTTGYLLTLGILVPISGLLLQWFTTRGLFFTAVSFSIAGTLIAALSPTFAMLMIGRVVQAVGTALLLPLMFNTILLIFPEHKRGSAMGMIGLVIMFAPAVGPTISGLILENLTWNWIFWISLPFLIIALLFGMKFMQNVSVVTKPKIDILSIILSTLGFGGVVFAFSSAGESGWGSATVLVSIIVGGIALGLFVWRQLTMEKPLMDLKVFKYPMFTLGLILVFISFMMILSTMILLPLYLQNSLALAAFSAGLVLLPGGVLNGLMSPFTGRLFDAYGPRALVIPGFIVAVVALFFLTRIEVGTSALTIIVLHSVLMIGISMVMMPAQTNGLNQLPPKLYPDGTAIMNTLQQVSGAIGTAVAITIMSAGQKAYMETAQGVGPEQMVASLTAGIQNAFVFGLIMACIGLLCSLFIRKAK

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Crispr_ID: CP021325_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP021325_3

2837430-2837540

Orphan

Consensus_repeat	Method
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP021325_3

>merge|CP021325|3|2837430-2837540|CRISPRCasFinder
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAATGTACTTTATTTTGATTTAGTTCTTCAATATAAATCTGAGCAAAGCGATGATTTAATCCTTCCCAGAACTTTCAAAA

>CP021325|3|3|2837430-2837540|CRISPRCasFinder
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA	TGTACTTTATTTTGATTTAGTTCTTCAATATAAATCTGAGCAA
AGCGATGATTTAATCCTTCCCAGAACTTTCAAAA

Protein	Signature genes	Signature genes Name	Protein_function
CP021325.1\|AVK46381.1\|2838309_2838531_-\|hypothetical-protein	unknown	unknown	unknown
CP021325.1\|AVK46383.1\|2840471_2840627_+\|hypothetical-protein	unknown	unknown	unknown
CP021325.1\|AVK46380.1\|2838124_2838307_-\|DUF3188-domain-containing-protein	unknown	unknown	gnl\|CDD\|371501
CP021325.1\|AVK46369.1\|2829355_2830345_+\|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl\|CDD\|237724
CP021325.1\|AVK46378.1\|2835576_2837316_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|235505
CP021325.1\|AVK46385.1\|2842537_2844052_-\|gluconate-kinase	unknown	unknown	gnl\|CDD\|212659
CP021325.1\|AVK46370.1\|2830366_2830963_+\|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl\|CDD\|274099
CP021325.1\|AVK46379.1\|2837642_2838107_-\|Soluble-KIT-ligand	unknown	unknown	gnl\|CDD\|378692
CP021325.1\|AVK46371.1\|2830966_2831341_+\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	unknown	unknown	gnl\|CDD\|184702
CP021325.1\|AVK46386.1\|2844167_2845106_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226309
CP021325.1\|AVK46382.1\|2838665_2840030_-\|PTS-cellobiose-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224372
CP021325.1\|AVK46372.1\|2831446_2832298_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
CP021325.1\|AVK46387.1\|2845148_2846096_-\|cell-surface-protein	unknown	unknown	gnl\|CDD\|273478
CP021325.1\|AVK46377.1\|2835229_2835547_-\|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669
CP021325.1\|AVK46374.1\|2833376_2834219_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|223729
CP021325.1\|AVK46375.1\|2834264_2834510_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378478
CP021325.1\|AVK46373.1\|2832416_2833256_+\|HAD-family-phosphatase	unknown	unknown	gnl\|CDD\|319818
CP021325.1\|AVK46376.1\|2834524_2835121_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
CP021325.1\|AVK46388.1\|2846236_2847976_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|227320
CP021325.1\|AVK46384.1\|2841198_2841840_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP021325.1\|AVK46388.1\|2846236_2847976_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|227320	COG4987, CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones].	0
CP021325.1\|AVK46380.1\|2838124_2838307_-\|DUF3188-domain-containing-protein	gnl\|CDD\|371501	pfam11384, DUF3188, Protein of unknown function (DUF3188). This bacterial family of proteins has no known function.	1.21027e-11
CP021325.1\|AVK46369.1\|2829355_2830345_+\|dihydroxyacetone-kinase-subunit-DhaK	gnl\|CDD\|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
CP021325.1\|AVK46378.1\|2835576_2837316_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|235505	PRK05563, PRK05563, DNA polymerase III subunits gamma and tau; Validated.	0
CP021325.1\|AVK46385.1\|2842537_2844052_-\|gluconate-kinase	gnl\|CDD\|212659	cd07770, FGGY_GntK, Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of a group of gluconate kinases (GntK, also known as gluconokinase; EC 2.7.1.12) encoded by the gntK gene, which catalyzes the ATP-dependent phosphorylation of D-gluconate and produce 6-phospho-D-gluconate and ADP. The presence of Mg2+ might be required for catalytic activity. The prototypical member of this subfamily is GntK from Lactobacillus acidophilus. Unlike Escherichia coli GntK, which belongs to the superfamily of P-loop containing nucleoside triphosphate hydrolases, members in this subfamily are homologous to glycerol kinase, xylulose kinase, and rhamnulokinase from Escherichia coli. They have been classified as members of the FGGY family of carbohydrate kinases, which contain two large domains separated by a deep cleft that forms the active site. This model spans both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Some uncharacterized homologous sequences are also included in this subfamily. The Lactobacillus gnt operon contains a single gntK gene. The gnt operons of some bacteria, such as Corynebacterium glutamicum, have two gntK genes. For example, the C. glutamicum gnt operon has both a gluconate kinase gntV gene (also known as gntK) and a second hypothetical gntK gene (also known as gntK2). Both gluconate kinases encoded by these genes belong to this family, however the protein encoded by C. glutamicum gntV is not included in this model as it is truncated in the C-terminal domain.	0
CP021325.1\|AVK46370.1\|2830366_2830963_+\|dihydroxyacetone-kinase-subunit-L	gnl\|CDD\|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	3.29756e-82
CP021325.1\|AVK46379.1\|2837642_2838107_-\|Soluble-KIT-ligand	gnl\|CDD\|378692	pfam11687, DUF3284, Domain of unknown function (DUF3284). This family of proteins with unknown function appears to be restricted to Firmicutes.	5.35099e-31
CP021325.1\|AVK46371.1\|2830966_2831341_+\|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM	gnl\|CDD\|184702	PRK14484, PRK14484, phosphotransferase mannnose-specific family component IIA; Provisional.	1.1917e-48
CP021325.1\|AVK46386.1\|2844167_2845106_-\|hypothetical-protein	gnl\|CDD\|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	3.04876e-98
CP021325.1\|AVK46382.1\|2838665_2840030_-\|PTS-cellobiose-transporter-subunit-IIC	gnl\|CDD\|224372	COG1455, CelB, Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism].	3.47828e-162
CP021325.1\|AVK46372.1\|2831446_2832298_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	6.1079e-63
CP021325.1\|AVK46387.1\|2845148_2846096_-\|cell-surface-protein	gnl\|CDD\|273478	TIGR01167, Zinc_metalloprotease_ZmpB, LPXTG-motif cell wall anchor domain. This model describes the LPXTG motif-containing region found at the C-terminus of many surface proteins of Streptococcus and Streptomyces species. Cleavage between the Thr and Gly by sortase or a related enzyme leads to covalent anchoring at the new C-terminal Thr to the cell wall. Hits that do not lie at the C-terminus or are not found in Gram-positive bacteria are probably false-positive. A common feature of this proteins containing this domain appears to be a high proportion of charged and zwitterionic residues immediatedly upstream of the LPXTG motif. This model differs from other descriptions of the LPXTG region by including a portion of that upstream charged region. [Cell envelope, Other].	1.13667e-05
CP021325.1\|AVK46377.1\|2835229_2835547_-\|YbaB/EbfC-family-nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	3.53269e-41
CP021325.1\|AVK46374.1\|2833376_2834219_+\|aldo/keto-reductase	gnl\|CDD\|223729	COG0656, ARA1, Aldo/keto reductases, related to diketogulonate reductase [General function prediction only].	6.97706e-130
CP021325.1\|AVK46375.1\|2834264_2834510_-\|hypothetical-protein	gnl\|CDD\|378478	pfam10704, DUF2508, Protein of unknown function (DUF2508). This family is conserved in Firmicutes. Several members are annotated as being the protein YaaL. The function is not known.	2.68189e-15
CP021325.1\|AVK46373.1\|2832416_2833256_+\|HAD-family-phosphatase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.49073e-86
CP021325.1\|AVK46376.1\|2834524_2835121_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	7.77001e-132

>CP021325.1|AVK46378.1|2835576_2837316_-|DNA-polymerase-III-subunit-gamma/tau
MAYQALYRVFRPQSFQDVVGQEHVTKTLKNAIVQNKTSHAYLFSGPRGTGKTSAAKIFAKAINCEHGHDGEPCNECEICKGTTDGSIPDVLEIDAASNNGVEEIRDIREKVKYAPTVAKYKVYIIDEVHMLSTGAFNALLKTLEEPPKHVIFILATTEPHKLPLTIISRVQRFDFKRITTQDIIGRLKFILEEEKIPYDEKALMIVARAAEGGMRDALSLLDQVISYGSEEVTVEDALEITGSVAQNLLTKLVSAAFDGDAAEAISTLTALLAEGKDPVRLVEDLLVFFRDVLLYQKAPNLEETMERALIDDDFVALAKRADSLKVYEFVKILNTAQQQMRFSNHPGIYVEVALVQLTQAGQSVAGGGNVPADAASGSDVSDLKRQMEQMHQEIQTLKKQIASGAGAAPADKPTQNRGGSKKAINNGKQFKAPIGKINHVLGEAKKENLQLIRGCWGELLSMLMASQAALLNDAEPVAASQDTFVLKFKHEIHCQMAMDNPNFVETITSSIARLTQVNYTFIGIPEDQWADVRENFLHSHGSDADAEDGANPEAKKPAEDPFVAEAAKLVGEDLLEIKD
>CP021325.1|AVK46377.1|2835229_2835547_-|YbaB/EbfC-family-nucleoid-associated-protein
MRGMGNMQGMMKQMQKMQKEMAKAQADLEAQEFTGTAGGGMVTVKATGKRVITDVVINEEVVDPEDIEMLQDLVLAATNDVLKQIEDTTSQTMGKFTQGLNIPGM
>CP021325.1|AVK46376.1|2834524_2835121_-|recombination-protein-RecR
MHYPEPITKLIDSFMKLPGIGPKSAARLAFYVLDMKEDDVLDFAKALVDAKRNLSFCSVCGHITDKDPCYICADTSRDRSVICVVQESKDVIAMEKMRDFHGLYHVLHGTISPMDGIGPEDINIPDLLKRLQDDTIEEVILATNPNVEGEATAMYISRLLKPSGIKVTRIAHGLPVGGDLEYADEVTLSKAMEGRREV
>CP021325.1|AVK46375.1|2834264_2834510_-|hypothetical-protein
MESRSNKFGRKKNKKIGKLHKSYDAYLMELIEVTQENWHKQKVLMRKSFEYDPNLEYEEKKAEARYFYLFKEARTRQLKNK
>CP021325.1|AVK46374.1|2833376_2834219_+|aldo/keto-reductase
MTLSFSDTYRLNNGIEMPRHGFGVYKLTDEARMRTALETAVDVGYRLFDTASFYHNEKELGDFFASSGLKRDEFFVTTKMWNTEQGYDETLRAFEKSQKKLQLDQIDLYLVHWPKQDTFFDTWRAVEKLYDEGLVRAIGVSNFEAHHLDRLRTSANVLPVVDQLETHPHFPNHLLHRYLEELHIVHQAWSPLGRGGVLQEQILIDLAEKHGKSPAQIVLRWHLQNNISIIPKSETPSRIRENAAIYDFELSEADMRQVERLNTGERVSHAPDVMYVRSEI
>CP021325.1|AVK46373.1|2832416_2833256_+|HAD-family-phosphatase
MTTQAIILDIDGTLLNDDKQISPETKKALITAQENGVKLILASGRPTTGMHVYAEQLEMEKHHGLLVSYNGAKVVDCATNEELFNQALTVEEGKAVLEHMKQFEVKVMIDKEDYMYTNDVYDCYVPYRGEEINIIQYESRGGNFKLCEKDDLAAFLDYRLSKILTAGDPAYMQKNYQAMMAPFKDTLNCVFTADFYFEFTAQGIDKAKALDTVLTPMGIHAENVIAFGDGHNDITMVEYAGTGIAMQNAVPELKAAASSVTLSNNEDGIAHVLNSLIPS
>CP021325.1|AVK46372.1|2831446_2832298_+|MurR/RpiR-family-transcriptional-regulator
MNILIKIRELTNLTNSEKELANYILANPKKTLQFKPKELATAAFVSAATIYRLINKLGLNGIGELKIEIASSLRETSEEKDLNYDYPILESDTPYQIMTNLHQIYKGTIDETLNNADPEELVKIGEKLIQAKTIDVYAASANLFFAQNFKFQMQEIGVLVNVPEEDYIQSLSAANSDENHIAIVVSYGGRSRTLQRVVKILSENNVDIILITSMQDNPLVEFATHKIYMASAENHYNKVSSFSTRQSLLSIFDTLYSIYFNQNYEKNIQYKTTNYQKMNTELE
>CP021325.1|AVK46371.1|2830966_2831341_+|PTS-dependent-dihydroxyacetone-kinase-phosphotransferase-subunit-DhaM
MAKPYGVVIISHSKDVAKGVHDIIKEIAPDVSITHAGGTEDGRIGTSFDAVNEAIENNEANKVYTFYDLGSAKMNIETVEEISEKEIILFNAPILEGAYATAAQVQMDEKPEVIAANLKTIEIK
>CP021325.1|AVK46370.1|2830366_2830963_+|dihydroxyacetone-kinase-subunit-L
MTYDKDWALRWLNDFGERVQENKQLLSDLDQAIGDGDHGINMARGLGELKKAFTEKEPADLKDVFKTAGMTMVSKVGGASGPLYGTAFLNMSKAVDADTIDAVGLTKVIEAGLEGIEKRGKSHAGEKTMIDVWEPVVHALHQEDLTDDVVDAALQKTKDLKATKGRASYLGERSIGHLDPGAYSSALLFHAMLQTEVS
>CP021325.1|AVK46369.1|2829355_2830345_+|dihydroxyacetone-kinase-subunit-DhaK
MKKILNGTDQVVEQMVEGLVKSHADVVHRVEGTRVIARNDKRPGKVGLVSGGGSGHEPAHAGYVGRGMLSAAVCGDVFTSPTPDQIYEGIKAADQGAGVLLIVKNYTGDVMNFEMAADLADADDIKVEQIVVDDDIAVEDSTFTTGRRGVAGTVLVHKIIGAAAEAGASLDELKALGEKVIASVKTLGVALSPCTVPEVGHPGFELGDDEIELGIGIHGEPGFTREKIMPSASLAKQLYERISNESKLLAGDKVVVLVNGMGATPLMEQYVFANDVHELLKNAGVQVEKTLVGDYMTSLEMAGLSLTILKLEDEKWVDMLKLPVDTIAW
>CP021325.1|AVK46379.1|2837642_2838107_-|Soluble-KIT-ligand
MNVTQKLYISQKECFDTLVSSAIYDVKNATGKTLQVRKLEGYKYQRTMSNGALATTKIVKVQPNELYQFETSSRVNTHTTTYTIKSTSETTCEVTYNELIETEKALNKMNNIIVGFMFGFFRKKRVKNLLKSIELSVINESKQKQEKLAAKSEQ
>CP021325.1|AVK46380.1|2838124_2838307_-|DUF3188-domain-containing-protein
MKIVNALFLISIGLIIIMFSPSYGKDGMASVPLLVTGLAVVLIGCVFIVLKIRKDKKEKN
>CP021325.1|AVK46381.1|2838309_2838531_-|hypothetical-protein
MIILNCPMKRDYITELLETYDKDGVTFKKIDEKGMKLTFETNIEDEEKAAKIAKETIKATEIGSVLYFQVSVG
>CP021325.1|AVK46382.1|2838665_2840030_-|PTS-cellobiose-transporter-subunit-IIC
MNGLTAFLEKYFVPVAAKIGSQKHLVALRDAFISTMPITMAGSIAVLLNAFFRDFPTDWGWTGFVEAMQPLIGINGYVYNGTLAIVSIIFAFSLGYNLSKAYEVDRLAGGLVSLAAFVMNLTVTVSLDAVKAAIAASNANFDVATLPKEFAGIYGFFSLSQVNGTGLFTAMIFGFISTIIYAKLMRRNIIIKMPDSVPPAVSKAFAAIIPALVALYVVGIIDWAFFKITNMDVITWISKTIQEPLLSLSQGYGAVLLVTFLVQLLWFFGIHGPNVLAPVLESLWGTAQLQNISAAQEGAKLPFEWVRGSFDAYVWMGGSGGTLVLIIALLMFSKRADARTVAKLSLAPGIFNINEPIMFGLPIVLNTIYLIPFLIAPMVMVTIAYFATTLGIVGPVKIAVVWVMPPLLNSFLATGGDWMAPVISLINMVVAFLIWVPFVITANRVGVPEEEMKA
>CP021325.1|AVK46383.1|2840471_2840627_+|hypothetical-protein
MAVKRDMPEESKNSKVVKKEHFSIVFPDDIKEPATVEEKKKQDAEKKTDDN
>CP021325.1|AVK46384.1|2841198_2841840_-|hypothetical-protein
MQQLKSKKKWLPALIVAVFVGIIVILAIMFGFFQRQEVFDKYEVAYEIDGKLYEVFPISATDIGVDKKSKDKNLYFRVNSYYNIDYLFRLAYKQYEINEPSTNKYYSGLIDYSVADNAYVTQKDVYITNNESYATYDFFDKNGKKIYTYNPEETSNDDYIVRIKPTILQGYEKSDIGSYDDYLNITALFKDKLGMDVNVRIDEDKEMVIFSIK
>CP021325.1|AVK46385.1|2842537_2844052_-|gluconate-kinase
MTSKPYIMGVDIGTSSTKAVLFNQRGEVIFRQATHYELITDETGKAEESPTEIFDAVLTSIQAVMKNINTEELAGISFSSAMHSLIMVGSNGELLTECITWADGRSSETLEKVKRDNYLFQLYEATGTPIHPMSPFAKICWLKEEKPTLFKRTEKFVDIKSYILYRLFGVWVMDESLASGTGLYNIMEHDWEFEAMEIVKLTPDFLPKVVPETYQLAGVKKEYAELMGIPENLPFIIGGSDGALANIGIQATGQNDVTITVGTSGAVRKLTDQFQIDSRGRTFCYGAGDGYFIAGGAVNNGGKVVEWGLQQFGSEAEISRRDFASFIAKIEEVPPGAAGLLFQPYLLGERAPFWTNDIRGGFVGLTINHTKAHFIRAILEGVAFNLAEVYEAVSAPDDIIYVTGGISAHDAWCKLLADILNREIRVPHTIEGSSLGAAIIGMRSLGILKDLNLKHTLPIKAVYHPSENVLKYAELRLIFKQVTTQLMSSYSQLNSWQKKFDINS
>CP021325.1|AVK46386.1|2844167_2845106_-|hypothetical-protein
MKKLLSGLIVVLMVSLLGHSFNAEAASYEKIIYDKAVNLKGVVNQSKRNDGINSKMYKTSSSVKYLGSAKKYDKKTLIITREGKTARAKWYYCKLGNTTIGWIDSRAFTNIGKPTIADAVPALWNSKKAIITTKPKSTTATTYFFQKNSAGNWYEVRHFTSHIGKWGFDPKFSEKSSGTPVGVYRTGIAFGQKGNPGTKLTFRAITNRSYWISNSNDKAYNTWQERNSSSSADEKMKIPQYKYGMEVKYNAKRVKGKGSAVFYHVDSPKYNYTLGCVAQSEANTKEVLKFADKNTLIVLGEESRIKTFYGIN
>CP021325.1|AVK46387.1|2845148_2846096_-|cell-surface-protein
MKKFHGLILTALVTCLIIPFSLAASAETNENGNNSTPTEEKTTDTTENIITEEKTEPAEPTKDTTVTPPQKSKVQTTIDITDSQEVYSYEQNSKIDLKDFTATLTDYTDTKLTNYRLAANSKLSTAQTGIQEVTLLGDNEDGKTTAVKLNYLVKEKTAQLTITDMNFDLETKIFTGKTKPFASVYMSSPADENFGEGTTTADKDGYFYAEWATTPKQITAYAFDESGNYSEEVTYQVPAKKQNEAVVTAPDKVKKIETKNAVKSATTKPTDVTKVTKDDKTDLPSTGDKGTEWIFVVAGVIVILVAVLLLRKRKK
>CP021325.1|AVK46388.1|2846236_2847976_-|amino-acid-ABC-transporter-ATP-binding-protein
MRKSSWIIPYIKENRGLFLLVIFLGTLTFASAGALMFTSGHLISKSSLMPESIMAVYISTVGVRAFGIMRSVSRYVERLSSHSLVLRILEKMRVRLYRLLEPQALLLKSRYKTGDILGLLAGDIEHLQNFYLTTMLPAIVSLVLYAGVVIALGAFSIPFAALFVLLIGLLVLVLPWVSLLYARGKNAYLKQGRNSLYQKFTDAVFGISDWKFSGREKTFISNYEKDEADMLRTENKQFHFVNWRDFFSQLVVGFMVIVMVYWSTAESRDGAFSGTLIAAFVLAIMALAEAFVPVSSAISDKSLYQDSLARLDKIEDPALPTFEEETKEIERINTENVVLKAENLTFAYNEKSPEILNGFDFTLQQGEKVAIIGRSGTGKSTFLKLVQGALLPTAGKVTMNDVEVEKLRPQIPELTSMLNQKAHLFSTTVLNNIRLGNQDASDEEVYEAAKKVQLHDFIMSMPDGYHTQMSEMGERFSGGERGRIALARILLQNTPIVILDEPTVGLDPITERDLLATIFETLADKSLIWVTHHLVGAEKMDRVLFLEEGKTLMEGPHAELMAEEPRYKRLYQLDRPIEL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP021325_2	2.3\|537027\|35\|CP021325\|PILER-CR,CRISPRCasFinder,CRT	537027-537061	35	MH341453	Listeria phage PSU-VKH-LP041, complete genome	10139-10173	1	0.971
CP021325_2	2.3\|537027\|35\|CP021325\|PILER-CR,CRISPRCasFinder,CRT	537027-537061	35	NC_009813	Listeria phage B054, complete genome	10139-10173	2	0.943

1. spacer 2.3|537027|35|CP021325|PILER-CR,CRISPRCasFinder,CRT matches to MH341453 (Listeria phage PSU-VKH-LP041, complete genome) position: , mismatch: 1, identity: 0.971

gcgatttttgtcaaagggacagcgatgggttacaa	CRISPR spacer
gcgatttttgtcaaaggaacagcgatgggttacaa	Protospacer
*****************.*****************

2. spacer 2.3|537027|35|CP021325|PILER-CR,CRISPRCasFinder,CRT matches to NC_009813 (Listeria phage B054, complete genome) position: , mismatch: 2, identity: 0.943

gcgatttttgtcaaagggacagcgatgggttacaa	CRISPR spacer
gcgatttttgtcaaaggaacggcgatgggttacaa	Protospacer
*****************.**.**************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

120423 : 126948

Listeria_phage(33.33%)

tail

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVK43662.1\|120423_120876_-	toxin	A0A059T7S0	Listeria_phage	4.0e-31	47.9
AVK43663.1\|120881_121217_-	transcriptional regulator	A0A2H4JAR9	uncultured_Caudovirales_phage	4.0e-20	52.5
AVK43664.1\|121433_121862_+	hypothetical protein	NA	NA	NA	NA
AVK43665.1\|121873_122290_+	hypothetical protein	A8ASQ1	Listeria_phage	1.3e-20	39.3
AVK43666.1\|122567_122957_+	DUF5072 domain-containing protein	NA	NA	NA	NA
AVK43667.1\|122969_123482_+\|tail	phage major tail protein, TP901-1 family	A0A097PBF4	Streptococcus_pyogenes_phage	1.2e-47	62.7
AVK43668.1\|123529_123832_+	segregation and condensation protein B	NA	NA	NA	NA
AVK43669.1\|123873_124278_+	phenylalanine racemase	NA	NA	NA	NA
AVK43670.1\|124264_126133_+	hypothetical protein	A0A097PAU2	Streptococcus_pyogenes_phage	3.5e-20	45.8
AVK43671.1\|126129_126948_+\|tail	phage tail family protein	A0A060AFE1	Staphylococcus_phage	7.2e-39	35.0

DBSCAN-SWA_2

670048 : 706293

Listeria_phage(51.61%)

capsid,head,portal,integrase,tail,holin,terminase

attL 677270:677284|attR 681640:681654

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVK44192.1\|670048_671200_-\|integrase	site-specific integrase	A8ATX2	Listeria_phage	3.4e-87	46.3
AVK44193.1\|671221_671935_-	hypothetical protein	NA	NA	NA	NA
AVK44194.1\|671989_672490_-	hypothetical protein	A0A1S7FYX8	Listeria_phage	3.2e-13	31.9
AVK44195.1\|672502_672829_-	XRE family transcriptional regulator	Q0H244	Geobacillus_phage	1.6e-13	47.1
AVK44196.1\|673003_673195_+	XRE family transcriptional regulator	Q0H243	Geobacillus_phage	1.1e-09	57.6
AVK44197.1\|673292_673619_+	hypothetical protein	A0A2H4J474	uncultured_Caudovirales_phage	4.9e-15	41.1
AVK44198.1\|673791_674706_+	hypothetical protein	A0A1W6JNI1	Staphylococcus_phage	1.7e-57	51.1
AVK44199.1\|674707_675064_+	MerR family transcriptional regulator	NA	NA	NA	NA
AVK44200.1\|675060_675477_+	hypothetical protein	NA	NA	NA	NA
AVK44201.1\|675952_676162_+	hypothetical protein	A0A060ALG0	Listeria_phage	1.0e-29	92.8
AVK44202.1\|676158_676542_+	preprotein translocase subunit YajC	A0A060ALS5	Listeria_phage	2.0e-55	89.0
AVK44203.1\|676563_676965_+	hypothetical protein	A8ATZ6	Listeria_phage	6.0e-63	93.2
677270:677284	attL	NA	NA	NA	NA
AVK44204.1\|677276_677504_+	RNA-binding protein	A0A059T7N3	Listeria_phage	2.1e-28	85.3
AVK44205.1\|677515_677872_+	hypothetical protein	A0A059T801	Listeria_phage	2.9e-45	87.0
AVK44206.1\|677871_678351_+	single-stranded DNA-binding protein	A8ASP5	Listeria_phage	1.5e-68	81.9
AVK44207.1\|678417_678609_+	hypothetical protein	NA	NA	NA	NA
AVK44208.1\|678669_679188_+	RNA polymerase subunit sigma	NA	NA	NA	NA
AVK44209.1\|679184_679727_+\|integrase	site-specific integrase	H0USV4	Bacillus_phage	4.3e-48	53.3
AVK44210.1\|679744_680083_+	hypothetical protein	NA	NA	NA	NA
AVK44211.1\|680346_680673_+	hypothetical protein	NA	NA	NA	NA
AVK44212.1\|680669_681032_+	HNH endonuclease	A0A075M5R4	Enterococcus_phage	3.5e-14	44.1
AVK44213.1\|681126_681654_+	hypothetical protein	J7KC46	Streptococcus_phage	6.1e-31	46.7
681640:681654	attR	NA	NA	NA	NA
AVK44214.1\|681622_683374_+\|terminase	terminase large subunit	A0A2H4JCI4	uncultured_Caudovirales_phage	6.9e-156	50.5
AVK44215.1\|683380_683581_+	hypothetical protein	NA	NA	NA	NA
AVK44216.1\|683583_684819_+\|portal	phage portal protein	A0A2H4JAR2	uncultured_Caudovirales_phage	2.7e-82	42.1
AVK44217.1\|684815_685382_+	hypothetical protein	A0A1D6Z2A7	Staphylococcus_phage	2.7e-45	52.7
AVK44218.1\|685446_686616_+\|capsid	phage major capsid protein	A0A060AI54	Enterococcus_phage	1.4e-43	37.7
AVK44219.1\|686664_687003_+	hypothetical protein	A0A2H4JB77	uncultured_Caudovirales_phage	8.1e-13	37.8
AVK44220.1\|686972_687293_+\|head,tail	head-tail adaptor protein	NA	NA	NA	NA
AVK44221.1\|687286_687652_+	hypothetical protein	NA	NA	NA	NA
AVK44222.1\|687654_688053_+	hypothetical protein	NA	NA	NA	NA
AVK44223.1\|688073_688649_+\|tail	phage tail protein	M1PRQ7	Streptococcus_phage	7.1e-33	42.9
AVK44224.1\|688738_689086_+	hypothetical protein	NA	NA	NA	NA
AVK44225.1\|689282_693482_+\|tail	phage tail tape measure protein	J7KDT4	Streptococcus_phage	1.6e-12	33.0
AVK44226.1\|693474_695718_+\|tail	phage tail protein	A0A059T682	Listeria_phage	2.9e-58	30.1
AVK44227.1\|695723_698015_+	hypothetical protein	A0A059T7Y6	Listeria_phage	3.1e-132	37.6
AVK44228.1\|698007_699069_+	hypothetical protein	A8ATW1	Listeria_phage	1.0e-93	68.6
AVK44229.1\|699107_699473_+	hypothetical protein	Q9T1A0	Listeria_phage	7.4e-12	100.0
AVK44230.1\|699485_699764_+\|holin	holin	R4IDW2	Listeria_phage	2.0e-41	94.6
AVK44231.1\|699767_700613_+	peptidase M15	A0A059T7Y8	Listeria_phage	4.8e-139	94.7
AVK44232.1\|700749_701115_+	hypothetical protein	NA	NA	NA	NA
AVK44233.1\|701242_703183_+	adenine methyltransferase	A0A1W6JNK1	Staphylococcus_phage	9.9e-188	54.2
AVK44234.1\|703281_704217_+	hypothetical protein	NA	NA	NA	NA
AVK44235.1\|705458_706088_+	hypothetical protein	A8ASL7	Listeria_phage	1.9e-100	90.4
AVK44236.1\|706110_706293_+	hypothetical protein	A8ASL8	Listeria_phage	3.0e-22	89.8

DBSCAN-SWA_3

1151062 : 1158485

Hokovirus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVK44691.1\|1151062_1151446_+	glycerol-3-phosphate cytidylyltransferase	A0A1V0SGE7	Hokovirus	1.4e-16	40.7
AVK44692.1\|1151467_1152451_+	glycosyl transferase	A0A1V0SAH6	Catovirus	4.1e-12	34.6
AVK44693.1\|1152465_1153479_+	glycosyl transferase	A0A1V0SAH6	Catovirus	7.9e-11	32.0
AVK44694.1\|1153687_1155178_+	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	9.5e-114	49.7
AVK44695.1\|1155189_1156014_+	NAD(+) synthetase	G3MA24	Bacillus_virus	7.4e-68	52.6
AVK44696.1\|1156026_1156335_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
AVK44697.1\|1156395_1156800_+	PTS sugar transporter subunit IIB	NA	NA	NA	NA
AVK44698.1\|1156928_1158485_+	GMP synthase (glutamine-hydrolyzing)	A0A1V0SH76	Hokovirus	2.3e-17	28.1

DBSCAN-SWA_4

1272534 : 1315276

Listeria_phage(91.3%)

capsid,head,portal,integrase,tail,holin,terminase

attL 1272418:1272434|attR 1315388:1315404

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1272418:1272434	attL	NA	NA	NA	NA
AVK44826.1\|1272534_1273689_-\|integrase	site-specific integrase	A0A059T688	Listeria_phage	1.3e-211	96.9
AVK44827.1\|1273820_1274435_-	hypothetical protein	A0A059T7Z1	Listeria_phage	7.7e-78	77.0
AVK44828.1\|1274485_1274938_-	toxin	R4IBK9	Listeria_phage	4.8e-77	90.0
AVK44829.1\|1274954_1275278_-	transcriptional regulator	A0A059T6G1	Listeria_phage	1.0e-33	68.2
AVK44830.1\|1275676_1275880_-	hypothetical protein	NA	NA	NA	NA
AVK44831.1\|1275946_1276138_+	transcriptional regulator	A0A059T5F8	Listeria_phage	5.4e-22	87.1
AVK44832.1\|1276159_1276402_+	hypothetical protein	A8ATD2	Listeria_phage	3.9e-41	93.8
AVK44833.1\|1276404_1276590_+	hypothetical protein	A8ATD3	Listeria_phage	5.4e-27	93.4
AVK44834.1\|1277065_1277293_+	hypothetical protein	NA	NA	NA	NA
AVK44835.1\|1277289_1277754_+	SAM-dependent methyltransferase	A0A059T693	Listeria_phage	9.0e-87	96.1
AVK44836.1\|1277750_1278311_+	hypothetical protein	A8ATY9	Listeria_phage	9.4e-107	100.0
AVK44837.1\|1278369_1278771_+	hypothetical protein	A8ATD9	Listeria_phage	2.6e-74	100.0
AVK44838.1\|1278767_1278977_+	hypothetical protein	A8ATE0	Listeria_phage	1.7e-32	100.0
AVK44839.1\|1279200_1279488_+	hypothetical protein	NA	NA	NA	NA
AVK44840.1\|1279709_1280306_+	hypothetical protein	A0A059T7S4	Listeria_phage	1.2e-14	32.3
AVK44841.1\|1280302_1280782_+	hypothetical protein	NA	NA	NA	NA
AVK44842.1\|1280782_1281412_+	hypothetical protein	A0A191KBJ8	Streptococcus_virus	1.1e-66	58.4
AVK44843.1\|1281430_1281664_+	hypothetical protein	NA	NA	NA	NA
AVK44844.1\|1281660_1281891_+	hypothetical protein	NA	NA	NA	NA
AVK44845.1\|1281880_1282147_+	hypothetical protein	NA	NA	NA	NA
AVK44846.1\|1282650_1283028_+	hypothetical protein	A8ATE8	Listeria_phage	8.7e-40	65.4
AVK44847.1\|1283031_1283511_+	hypothetical protein	R4IBM0	Listeria_phage	7.6e-57	76.7
AVK44848.1\|1283530_1284220_+	DNA-binding protein	R4IDY8	Listeria_phage	3.1e-128	96.9
AVK44849.1\|1284298_1285540_+	ATP-dependent helicase	A8ATF1	Listeria_phage	3.5e-210	93.4
AVK44850.1\|1285565_1286048_+	hypothetical protein	A8ATF2	Listeria_phage	5.5e-87	98.8
AVK44851.1\|1286070_1288344_+	DNA primase	R4IBW2	Listeria_phage	0.0e+00	95.0
AVK44852.1\|1288679_1288997_+	VRR-NUC domain-containing protein	A8ATF4	Listeria_phage	9.2e-51	95.1
AVK44853.1\|1288998_1289211_+	hypothetical protein	NA	NA	NA	NA
AVK44854.1\|1289719_1290253_+	hypothetical protein	A8ATF5	Listeria_phage	7.4e-77	79.4
AVK44855.1\|1290470_1290698_+	hypothetical protein	NA	NA	NA	NA
AVK44856.1\|1290710_1291136_+	hypothetical protein	Q8W5V4	Listeria_phage	6.3e-71	96.5
AVK44857.1\|1291361_1292297_+	hypothetical protein	NA	NA	NA	NA
AVK44858.1\|1292575_1292890_+	HNH endonuclease	A8ATF8	Listeria_phage	1.5e-56	98.1
AVK44859.1\|1292938_1293295_+	hypothetical protein	A0A059T7Y1	Listeria_phage	2.0e-46	98.0
AVK44860.1\|1293291_1294935_+\|terminase	terminase	A0A059T7Q8	Listeria_phage	0.0e+00	99.3
AVK44861.1\|1294944_1295334_-	hypothetical protein	A0A1Q1PVT8	Staphylococcus_phage	3.7e-17	39.8
AVK44862.1\|1295384_1296515_+\|portal	phage portal protein	A0A059T6F0	Listeria_phage	2.8e-214	99.5
AVK44863.1\|1296511_1297228_+	peptidase	A0A1S5SFF8	Streptococcus_phage	9.3e-67	59.0
AVK44864.1\|1297254_1298406_+\|capsid	phage major capsid protein	A0A059T678	Listeria_phage	3.1e-213	99.5
AVK44865.1\|1298592_1298892_+	hypothetical protein	A8ATA0	Listeria_phage	9.9e-47	98.0
AVK44866.1\|1298875_1299241_+\|head,tail	phage head-tail adapter protein	A8ATA1	Listeria_phage	2.7e-62	96.7
AVK44867.1\|1299237_1299639_+	hypothetical protein	A8ATA2	Listeria_phage	2.0e-66	97.0
AVK44868.1\|1299635_1300019_+	DUF3168 domain-containing protein	A8ATA3	Listeria_phage	4.2e-66	99.2
AVK44869.1\|1300040_1300628_+\|tail	phage tail protein	A8ATA4	Listeria_phage	4.0e-108	100.0
AVK44870.1\|1300698_1301031_+	hypothetical protein	A8ATA5	Listeria_phage	1.8e-52	99.1
AVK44871.1\|1301246_1306172_+\|tail	phage tail tape measure protein	A0A059T5F4	Listeria_phage	0.0e+00	92.6
AVK44872.1\|1306164_1307814_+\|tail	phage tail protein	A0A059T682	Listeria_phage	0.0e+00	99.5
AVK44873.1\|1307826_1310121_+	hypothetical protein	A0A059T7Y6	Listeria_phage	0.0e+00	95.3
AVK44874.1\|1310110_1311202_+	carbohydrate-binding protein CenC	A0A059T7R4	Listeria_phage	3.9e-189	91.5
AVK44875.1\|1311240_1311606_+	hypothetical protein	Q9T1A0	Listeria_phage	7.4e-12	100.0
AVK44876.1\|1311618_1311900_+\|holin	holin	A8ASL4	Listeria_phage	3.4e-41	94.6
AVK44877.1\|1311899_1312742_+	peptidase M15	A0A059T7Y8	Listeria_phage	9.5e-127	81.6
AVK44878.1\|1312845_1313844_+	hypothetical protein	A0A0N9RUA4	Staphylococcus_phage	3.9e-71	44.8
AVK44879.1\|1314058_1314265_-	hypothetical protein	A0A059T7Z0	Listeria_phage	1.3e-16	82.8
AVK44880.1\|1314854_1315088_+	hypothetical protein	R4IDW6	Listeria_phage	2.8e-28	78.9
AVK44881.1\|1315084_1315276_+	hypothetical protein	R4IBI5	Listeria_phage	8.9e-25	88.9
1315388:1315404	attR	NA	NA	NA	NA

DBSCAN-SWA_5

1886714 : 1895000

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVK45417.1\|1886714_1887281_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	7.0e-25	35.9
AVK45418.1\|1887277_1888327_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.0e-61	43.2
AVK45419.1\|1888345_1889773_-	amidophosphoribosyltransferase	A0A1B1ISH6	uncultured_Mediterranean_phage	8.1e-54	31.9
AVK45420.1\|1889757_1891977_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.0e-160	41.2
AVK45421.1\|1891969_1892653_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
AVK45422.1\|1892656_1892902_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
AVK45423.1\|1892913_1893627_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A0E3F9V5	Synechococcus_phage	2.3e-41	38.3
AVK45424.1\|1893707_1895000_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	7.2e-17	32.6

DBSCAN-SWA_6

2394106 : 2450223

Listeria_phage(92.73%)

capsid,protease,tail,holin,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVK45910.1\|2394106_2394628_-\|protease	protease	NA	NA	NA	NA
AVK45911.1\|2394791_2395136_-	hypothetical protein	NA	NA	NA	NA
AVK45912.1\|2395132_2395324_-	hypothetical protein	NA	NA	NA	NA
AVK45913.1\|2395474_2395825_+	PTS lactose/cellobiose transporter subunit IIA	NA	NA	NA	NA
AVK45914.1\|2395815_2396691_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
AVK45915.1\|2396770_2397079_-	DNA methyltransferase	NA	NA	NA	NA
AVK45916.1\|2397143_2397896_-	hypothetical protein	NA	NA	NA	NA
AVK45917.1\|2398014_2398860_+	HAD family hydrolase	NA	NA	NA	NA
AVK45918.1\|2398937_2399840_-	YitT family protein	NA	NA	NA	NA
AVK45919.1\|2399923_2400286_-	hypothetical protein	NA	NA	NA	NA
AVK45920.1\|2400306_2401155_-	fumarylacetoacetate hydrolase	NA	NA	NA	NA
AVK45921.1\|2401155_2404863_-	ATP-dependent helicase/nuclease subunit A	G3MA40	Bacillus_virus	8.1e-21	27.5
AVK45922.1\|2404864_2408338_-	ATP-dependent helicase/deoxyribonuclease subunit B	NA	NA	NA	NA
AVK45923.1\|2408487_2408844_-	hypothetical protein	NA	NA	NA	NA
AVK45924.1\|2408974_2409232_+	competence protein ComK	NA	NA	NA	NA
AVK45925.1\|2409252_2409450_-	hypothetical protein	A8ATC6	Listeria_phage	2.3e-15	66.7
AVK45926.1\|2409446_2409680_-	hypothetical protein	A0A059T6E1	Listeria_phage	2.8e-36	97.4
AVK45927.1\|2410071_2410365_-	hypothetical protein	NA	NA	NA	NA
AVK45928.1\|2410374_2410599_-	hypothetical protein	NA	NA	NA	NA
AVK45929.1\|2410595_2411222_-	hypothetical protein	NA	NA	NA	NA
AVK45930.1\|2411553_2412297_-	peptidase	A8ASL5	Listeria_phage	2.8e-74	65.5
AVK45931.1\|2412296_2412554_-\|holin	phage holin	A8ATB7	Listeria_phage	3.2e-25	70.2
AVK45932.1\|2412553_2412856_-	hypothetical protein	A0A059T5E6	Listeria_phage	5.9e-39	93.1
AVK45933.1\|2412906_2415072_-	hypothetical protein	A8ATW1	Listeria_phage	0.0e+00	87.2
AVK45934.1\|2415084_2416653_-\|tail	phage tail protein	A8ATW0	Listeria_phage	4.9e-302	97.9
AVK45935.1\|2416649_2421449_-\|tail	phage tail tape measure protein	A8ATV9	Listeria_phage	0.0e+00	89.6
AVK45936.1\|2421453_2421765_-	hypothetical protein	A0A0B5D116	Listeria_phage	1.0e-41	95.6
AVK45937.1\|2421761_2422193_-	hypothetical protein	A0A0B5D0B8	Listeria_phage	1.1e-73	98.6
AVK45938.1\|2422248_2422935_-	hypothetical protein	A0A0B5CYK8	Listeria_phage	3.6e-116	99.6
AVK45939.1\|2422939_2423311_-	hypothetical protein	A8ATV5	Listeria_phage	8.5e-64	100.0
AVK45940.1\|2423307_2423625_-	hypothetical protein	A8ATV4	Listeria_phage	1.4e-51	98.1
AVK45941.1\|2423614_2423980_-	hypothetical protein	A0A0B5D114	Listeria_phage	4.2e-63	95.0
AVK45942.1\|2423979_2424333_-	hypothetical protein	A8ATV2	Listeria_phage	1.2e-59	97.4
AVK45943.1\|2424502_2425375_-	hypothetical protein	A0A0B5CTX8	Listeria_phage	4.5e-164	99.7
AVK45944.1\|2425397_2425952_-	hypothetical protein	A8ATU9	Listeria_phage	1.1e-88	99.5
AVK45945.1\|2426047_2427091_-\|capsid	minor capsid protein	A0A0B5D111	Listeria_phage	1.6e-195	97.4
AVK45946.1\|2427095_2428655_-	hypothetical protein	A0A0B5D0A6	Listeria_phage	3.1e-293	97.3
AVK45947.1\|2428669_2429989_-\|terminase	terminase	A0A0B5CYJ6	Listeria_phage	5.1e-252	93.8
AVK45948.1\|2429981_2430707_-	helix-turn-helix domain-containing protein	A0A0B5CTX0	Listeria_phage	4.4e-80	68.5
AVK45949.1\|2430750_2430978_-	hypothetical protein	A0A0B5CTV3	Listeria_phage	2.4e-32	94.7
AVK45950.1\|2431253_2431688_-	hypothetical protein	A8ASQ1	Listeria_phage	3.1e-57	76.4
AVK45951.1\|2431752_2432250_-	Holliday junction resolvase RecU	A0A1L2JY30	Aeribacillus_phage	1.8e-32	49.3
AVK45952.1\|2432239_2432422_-	hypothetical protein	A8ASP6	Listeria_phage	3.6e-15	79.3
AVK45953.1\|2432443_2432926_-	single-stranded DNA-binding protein	A8ASP5	Listeria_phage	1.6e-70	83.8
AVK45954.1\|2432926_2433181_-	hypothetical protein	A0A059T5G2	Listeria_phage	3.4e-40	92.8
AVK45955.1\|2433180_2433363_-	hypothetical protein	NA	NA	NA	NA
AVK45956.1\|2433359_2433896_-	hypothetical protein	D9J0I6	Brochothrix_phage	2.3e-09	31.7
AVK45957.1\|2434060_2434270_-	hypothetical protein	A8ATE0	Listeria_phage	1.7e-32	100.0
AVK45958.1\|2434266_2434668_-	hypothetical protein	A8ATD9	Listeria_phage	2.6e-74	100.0
AVK45959.1\|2434888_2435449_-	hypothetical protein	A8ATY9	Listeria_phage	9.4e-107	100.0
AVK45960.1\|2435445_2435910_-	class I SAM-dependent methyltransferase	A0A059T693	Listeria_phage	6.9e-87	96.8
AVK45961.1\|2435974_2436583_-	hypothetical protein	A8ATU1	Listeria_phage	1.4e-55	49.5
AVK45962.1\|2436710_2437199_-	hypothetical protein	A8ATE4	Listeria_phage	2.2e-43	83.7
AVK45963.1\|2437277_2437493_-	hypothetical protein	NA	NA	NA	NA
AVK45964.1\|2437676_2438132_-	class I SAM-dependent methyltransferase	A0A059T693	Listeria_phage	4.2e-81	90.7
AVK45965.1\|2438128_2439052_-	DNA replication protein DnaD	A0A0B5D175	Listeria_phage	1.9e-120	79.8
AVK45966.1\|2439065_2439704_-	single-stranded DNA-binding protein	A8ASN3	Listeria_phage	3.0e-77	74.3
AVK45967.1\|2439708_2440185_-	hypothetical protein	A8ASN2	Listeria_phage	2.0e-57	94.9
AVK45968.1\|2440181_2440376_-	hypothetical protein	A0A059T6E8	Listeria_phage	1.8e-28	95.3
AVK45969.1\|2440677_2440866_-	hypothetical protein	A8ATY3	Listeria_phage	2.5e-27	95.2
AVK45970.1\|2440973_2441189_-	hypothetical protein	Q9T176	Listeria_phage	6.1e-22	73.2
AVK45971.1\|2441185_2441719_-	hypothetical protein	A0A059T5F0	Listeria_phage	1.1e-75	84.4
AVK45972.1\|2441843_2442623_-	phage antirepressor Ant	A0A059T6E7	Listeria_phage	2.0e-139	96.9
AVK45973.1\|2442686_2442929_+	hypothetical protein	A0A059T7Q3	Listeria_phage	1.5e-37	98.8
AVK45974.1\|2443114_2443396_-	hypothetical protein	Q9T180	Listeria_phage	1.4e-39	96.8
AVK45975.1\|2443392_2443629_-	hypothetical protein	A0A059T5E9	Listeria_phage	3.3e-37	100.0
AVK45976.1\|2443680_2443863_+	hypothetical protein	Q9T182	Listeria_phage	1.8e-22	98.2
AVK45977.1\|2444229_2444541_+	hypothetical protein	NA	NA	NA	NA
AVK45978.1\|2444500_2444686_-	hypothetical protein	NA	NA	NA	NA
AVK45979.1\|2444689_2444932_-	transcriptional regulator	A0A059T7X5	Listeria_phage	4.9e-36	98.8
AVK45980.1\|2445057_2445363_+	XRE family transcriptional regulator	A0A059T669	Listeria_phage	6.4e-49	100.0
AVK45981.1\|2445395_2445887_+	hypothetical protein	A8ATX4	Listeria_phage	3.9e-88	95.7
AVK45982.1\|2445909_2446128_+	zinc ribbon domain-containing protein	A0A059T6E3	Listeria_phage	2.3e-32	95.8
AVK45983.1\|2446143_2446866_+	hypothetical protein	A0A059T7P9	Listeria_phage	2.8e-103	98.3
AVK45984.1\|2446888_2447494_+	hypothetical protein	NA	NA	NA	NA
AVK45985.1\|2447506_2447929_+	hypothetical protein	NA	NA	NA	NA
AVK45986.1\|2447995_2449354_+	recombinase family protein	Q8LTD8	Listeria_phage	7.3e-254	98.5
AVK45987.1\|2449344_2449821_+	competence protein ComK	NA	NA	NA	NA
AVK45988.1\|2449875_2450223_-	transcriptional regulator	A0A0A7RTK4	Clostridium_phage	9.9e-06	40.7

DBSCAN-SWA_7

2593512 : 2601356

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVK46127.1\|2593512_2594484_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	5.2e-52	39.4
AVK46128.1\|2594491_2595460_-	gluconeogenesis factor	A1IMD5	Streptococcus_phage	6.7e-68	43.3
AVK46129.1\|2595461_2596337_-	RNase adaptor protein RapZ	A0A0R8VB27	Thermobifida_phage	3.2e-08	29.7
AVK46130.1\|2596444_2598175_-	phosphoglucomutase	A0A1X9I671	Streptococcus_phage	1.3e-175	54.0
AVK46131.1\|2598216_2599278_-	galactose mutarotase	NA	NA	NA	NA
AVK46132.1\|2599294_2600278_-	UDP-glucose 4-epimerase GalE	A0A2K9L1R4	Tupanvirus	2.6e-51	37.2
AVK46133.1\|2600396_2601356_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	2.0e-88	53.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP021325

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection