CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP027434	Microbacterium sp. str. 'China' chromosome, complete genome	3 crisprs	WYL,csa3,cas3,DEDDh	0	1	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP027434_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027434_1

416542-416671

Orphan

Consensus_repeat	Method
CCGGTCGGGATGCAGCCATTTGCGCTACTTCAACGGGGACGGTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027434_1

>merge|CP027434|1|416542-416671|CRISPRCasFinder
CCGGTCGGGATGCAGCCATTTGCGCTACTTCAACGGGGACGGTCGCCGACGGTCCCGGGCTTCGAGTCGCTTGAATGGCTGCATTTCCGGTCGGGATGCAGCCATTTGCGCTACTTCAACGGGGACGGTC

>CP027434|1|1|416542-416671|CRISPRCasFinder
CCGGTCGGGATGCAGCCATTTGCGCTACTTCAACGGGGACGGTC	GCCGACGGTCCCGGGCTTCGAGTCGCTTGAATGGCTGCATTT
CCGGTCGGGATGCAGCCATTTGCGCTACTTCAACGGGGACGGTC

Protein	Signature genes	Signature genes Name	Protein_function
CP027434.1\|AVL95965.1\|409471_410827_-\|nitrate-reductase	unknown	unknown	gnl\|CDD\|132655
CP027434.1\|AVL95963.1\|405674_407225_+\|allophanate-hydrolase	unknown	unknown	gnl\|CDD\|376868
CP027434.1\|AVL95964.1\|407221_408937_+\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|227111
CP027434.1\|AVL95980.1\|426924_427800_+\|hypothetical-protein	unknown	unknown	unknown
CP027434.1\|AVL95981.1\|427796_428219_+\|phage-holin-family-protein	unknown	unknown	gnl\|CDD\|377816
CP027434.1\|AVL95969.1\|414300_415785_+\|glutamine-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|270337
CP027434.1\|AVL95979.1\|426167_426773_-\|zinc-binding-alcohol-dehydrogenase	unknown	unknown	unknown
CP027434.1\|AVL95977.1\|422294_425741_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367875
CP027434.1\|AVL95968.1\|412620_414153_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
CP027434.1\|AVL95972.1\|418094_418769_-\|coenzyme-A-pyrophosphatase	unknown	unknown	gnl\|CDD\|239518
CP027434.1\|AVL95973.1\|418818_419187_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380033
CP027434.1\|AVL95962.1\|404874_405675_+\|putative-hydro-lyase	unknown	unknown	gnl\|CDD\|180100
CP027434.1\|AVL95974.1\|419183_419963_-\|heme-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|237422
CP027434.1\|AVL95967.1\|411943_412624_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
CP027434.1\|AVL95966.1\|410927_411803_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	unknown	unknown	gnl\|CDD\|237571
CP027434.1\|AVL95978.1\|425835_426171_+\|potassium-transporter-Trk	unknown	unknown	unknown
CP027434.1\|AVL95970.1\|415781_416510_+\|peptide-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
CP027434.1\|AVL95961.1\|404108_404873_+\|LamB/YcsF-family-protein	unknown	unknown	gnl\|CDD\|235446
CP027434.1\|AVL95976.1\|421023_422133_-\|hemin-receptor	unknown	unknown	gnl\|CDD\|226928
CP027434.1\|AVL95975.1\|419953_421027_-\|heme-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439

Protein	Function_ID	Function_description	E-value
CP027434.1\|AVL95965.1\|409471_410827_-\|nitrate-reductase	gnl\|CDD\|132655	TIGR03616, Putative_pyrimidine_permease_RutG, pyrimidine utilization transport protein G. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the uracil-xanthine permease family defined by TIGR00801. As well as the The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40).	2.17897e-100
CP027434.1\|AVL95963.1\|405674_407225_+\|allophanate-hydrolase	gnl\|CDD\|376868	pfam02626, CT_A_B, Carboxyltransferase domain, subdomain A and B. Urea carboxylase (UC) catalyzes a two-step, ATP- and biotin-dependent carboxylation reaction of urea. It is composed of biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP) domains. The CT domain of UC consists of four subdomains, named A, B, C and D. This domain covers the A and B subdomains of the CT domain. This domain covers the whole length of KipA (kinase A) from Bacillus subtilis. It can also be found in S. cerevisiae urea amidolyase Dur1,2, which is a multifunctional biotin-dependent enzyme with domains for urea carboxylase and allophanate (urea carboxylate) hydrolase activity.	4.15386e-91
CP027434.1\|AVL95964.1\|407221_408937_+\|ATP-grasp-domain-containing-protein	gnl\|CDD\|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
CP027434.1\|AVL95981.1\|427796_428219_+\|phage-holin-family-protein	gnl\|CDD\|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	3.38562e-29
CP027434.1\|AVL95969.1\|414300_415785_+\|glutamine-ABC-transporter-permease	gnl\|CDD\|270337	cd13619, PBP2_GlnP, Glutamine-binding domain of ABC transporter, a member of the type 2 periplasmic binding fold protein superfamily. Periplasmic glutamine binding domain GlnP serves as an initial receptor in the ABC transport of glutamine in eubacteria. GlnP belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.36941e-116
CP027434.1\|AVL95977.1\|422294_425741_+\|hypothetical-protein	gnl\|CDD\|367875	pfam04213, HtaA, Htaa. This domain is found in HtaA, a secreted protein implicated in iron acquisition and transport.	3.11043e-38
CP027434.1\|AVL95968.1\|412620_414153_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.28793e-85
CP027434.1\|AVL95972.1\|418094_418769_-\|coenzyme-A-pyrophosphatase	gnl\|CDD\|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	4.45766e-47
CP027434.1\|AVL95973.1\|418818_419187_+\|hypothetical-protein	gnl\|CDD\|380033	pfam17844, SCP_3, Bacterial SCP ortholog. This domain is found in MSMEG_5817 gene product from M. smegmatis. It has been shown to be vital for mycobacterial survival within host macrophages. Crystal structure revealed a Rossmann-like fold alpha/beta two-layer sandwich forming a highly hydrophobic interface cavity and with high structural homology to the SCP family. Hence, it has been suggested that this domain may be involved in the interaction of apolar ligands through its hydrophobic cavity. Alanine-scanning mutagenesis of the hydrophobic cavity of MSMEG_5817 protein demonstrated that the conserved Val82 residue plays an important role in ligand binding.	1.63641e-49
CP027434.1\|AVL95962.1\|404874_405675_+\|putative-hydro-lyase	gnl\|CDD\|180100	PRK05463, PRK05463, putative hydro-lyase.	5.70668e-163
CP027434.1\|AVL95974.1\|419183_419963_-\|heme-ABC-transporter-ATP-binding-protein	gnl\|CDD\|237422	PRK13548, hmuV, hemin importer ATP-binding subunit; Provisional.	9.97439e-109
CP027434.1\|AVL95967.1\|411943_412624_+\|transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	2.00715e-10
CP027434.1\|AVL95966.1\|410927_411803_-\|phosphoribosylaminoimidazolesuccinocarboxamide-synthase	gnl\|CDD\|237571	PRK13961, PRK13961, phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional.	4.31759e-165
CP027434.1\|AVL95970.1\|415781_416510_+\|peptide-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.07701e-159
CP027434.1\|AVL95961.1\|404108_404873_+\|LamB/YcsF-family-protein	gnl\|CDD\|235446	PRK05406, PRK05406, 5-oxoprolinase subunit PxpA.	3.2091e-120
CP027434.1\|AVL95976.1\|421023_422133_-\|hemin-receptor	gnl\|CDD\|226928	COG4558, ChuT, ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism].	9.42646e-60
CP027434.1\|AVL95975.1\|419953_421027_-\|heme-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	2.07415e-78

>CP027434.1|AVL95970.1|415781_416510_+|peptide-ABC-transporter-ATP-binding-protein
MSKIEVRDLHKSFGDNEVLKGIDLAVEDGEVIAVIGPSGSGKSTLLRCLNKLEEPTSGHVIIDGVDLTDKSVKLDEVRQRIGMVFQHFNLFPHMTVLENITLAPVELGRMTKAEARDRARSLLERVGLSEKADTKPASLSGGQKQRVAIARALAMDPEIMLFDEATSALDPEMVGEVLQVIRDLAEGGMTMVLVTHEMGFAREVSDRTVFMDGGVVVEEGTPADLFGAPKNERLQDFLSKVL
>CP027434.1|AVL95969.1|414300_415785_+|glutamine-ABC-transporter-permease
MSRHPSSPPSRLRRFGRTAGATALAALVAAGALLAGAAPATAADDGETYVIGTDTTFAPFEFTNESGDLVGIDMDLLRAIAEDQGFDVEIRQLGFDAAVQALQSNQVDAVMAGMSITEERQQTFDFSDPYFTSGVQLGVLESSDIESLDDLDGKTVAVKTGTQGQTFAEENADEYGFRITPYQDTTDMVDAVKAGQAVGYFEDFPVLAYGIQQGSGFRLVGEPALGGEYGFAVNKGENAELLEMFNAGLANLQDSGAYDEIVDTYLATRDDAQEAQPTDIISVAVKYWPALMQGLWLTILATIVAVIAAFILGIIFGFGRLSKFAPFRWIATAYVYVFRGTPILIQAFFVFFAIPQLIPDLKFDPFVAGAITLSLNTGAYMTEIIRGGIQAVDPGQAEASRSLGLSHWKTMRKVVLPQAFRIMIPSFVNQGIITLKDTSLISVIGLAELTFVSRQIIASTYLSAQVLTIVAIIYFVVITLLTLLANRLERKANA
>CP027434.1|AVL95968.1|412620_414153_+|MFS-transporter
MTDSRQTSGPETGPFAAGHAPKSPWPALWALVIGFFMILVDTTIVSVANPAIKAALDPDTNNLDNVVWVTSAYLLAYAVPLLITGRLGDRFGPKNIYLIGLAVFTLASLWCGLSTTLEGLIAARAVQGLGAALMTPQTMAVITRTFPPNRRGAAMGLWGATAGVATLVGPLAGGLLVDGFGWAWIFFVNLPVGVVAFVLAWILVPKLKTHPHRFDLVGVVLSAVALFLIVFGLQEGEKYDWGTIAGPISVWGLIIAGVVVLALFIVQQARTRSEPLVPLALFRDRNFSGANVAIAAVGFTVTSMSLPMMFFLQTARGLTPTEAAMLLIPMAVLSGVLAPVAGKILDRVDPRIILVPGLLCVAGALVWYSALTTMDTPILMFLLPSALMGIGNAGMWGPLATTATRKLPPRQAGAGAGIYNTTRTIGSVIGSASIAAFMQSRLEANLPGLADAPAGTGSGALPPKVAEGFAAGMSETLLLPAGVILIALVASLFLRGQDRKDEAVAATPPA
>CP027434.1|AVL95967.1|411943_412624_+|transcriptional-regulator
MWTIRAGRQSRGQGRGVGKNGDVVAGLTPLGVMVLALLRESDMHPYEMVRLLRARHDDRLITVTNGTLYHTVARLQRAGLLDEVGTDREGNRPERTTYTLTDAGREAVVAWVRRALPRIDRETDARVALAESHNLDRDDAVALLQERREALVASYALHHDGLASARAKGVPPQVLVEIERQEALLDAELRWLDSLLTRLDGDELRWGPDAFDDTDRYRAQRKAAQQ
>CP027434.1|AVL95966.1|410927_411803_-|phosphoribosylaminoimidazolesuccinocarboxamide-synthase
MSTPSAGNAQAIPGWRHLYSGKVRDLYASEDPADTRILVVASDRVSAFDVVLSPGITDKGALLTRLSRWWFAQLDVPNHLTDGDLPEEVADRAMLAQSLEMLPIECVVRGYITGSGWAEYQEHGTVCGIALPAGLQNGNRLPEPLFTPAYKAPMGEHDENITFDRVVELVGADRAAELRDASLAIYRRAAAIAEEKGLILADTKFEFGTDADGILRLADEVLTSDSSRYWDAEAWRTGSTPAERMASFDKQIVRDWLAANWDKQGEPPVLPEEVVARTAARYRELIDRLGA
>CP027434.1|AVL95965.1|409471_410827_-|nitrate-reductase
MALWKLHGNGRTVEPGAVVTPEERLSWLATIAIGAQHVVAMFGATFLVPTLTGFPVSTTLLFSGIGTLLFLLITKNQLPSYLGSSFAFIAPITAAVAAGGTGSALAGVVAVGVLLAVVGLVVQFVGLRWVDALMPPVVAGAIVALIGFNLAPTAWSNFALDPVTATITLVAIILFAVLFRGFLGRISIFLGVAVGFIWAAFNGSFEVPNPLRGDKTPAELIADAPWIGLPHFQFPDFVEPGTWSTIAMFLPVVLVLIAENVGHVRGVATMTEDPAINRHTGRALIADGVATTIAGGFGGSGTTTYGENIGVMAATRVYSTAVYWVAGLFAILLAFSPKVGEVFNSIPAGVLGGATTALYGLIGIIGIKIWVDSRVDFSRPVNQYTAAVSLVIGIAGFTMQLGDFAFGGIVLGTVAALLIYHLGNLIARARKTGADDPKPLEPVGPLGGDPA
>CP027434.1|AVL95964.1|407221_408937_+|ATP-grasp-domain-containing-protein
MTTVLIANRGEIAVRVIRACAEAGYTSVAVYADQDADALHVRLADEAIGLGGDTAATTYLSIEALIDAARRSGADAVHPGYGFLSESAAFARAVEDAGLVWIGPSPESIDALGDKMTARRIAQRVGAPLAAGTDQPLSGPQEAVAFAEEHGLPIAIKAAFGGGGRGLKVVRELSEVADAFDAATREATAAFGRGECFVERFLESPRHIEVQVLGDGRGGVVVVGDRDCSMQRRNQKLIEEAPAPGLTEAQRTAFHDAARAICAEVQYRGAGTVEFLLAADGTISFLEVNTRLQVEHPVTEEVTGTDLVREQFRIAFGEGPSFTETPAPTGHAFEFRINAEDPGRGFLPSPGRVDGLRIPGGPGVRWDSGIEAGDTVQPAFDSMIAKLIVHADTRDAALVRARRALRELAVEGPATVIPFDLRAIDDPAFATATFAVHTQWIETVLLPALEAQPRPAVAPVSGLQRFPVEIDGRRVMLGLPAELLAGIGRPAGEVAAPVSSADPSELRVPAPGTLVRWLVDDGAEVAEGDPVAVLDAMKMETTVTAHRAGTLTPRADTGATLAADALLATIA
>CP027434.1|AVL95963.1|405674_407225_+|allophanate-hydrolase
MRILTASDSALLVETDDLEQAMRLNLAWSDVPGVLERIPGARTVLVRFDPHRTSAAALAEVLAATEVDAAALPDAGEVTIPVRYDGEDLDEAAALLDVSAEELVARHLAADWRVAFSGFAPGFGYAVSGDPLFDVPRRSSPRTRVPAGSVALAGAFSGVYPRESPGGWQLIGRTALEMWDIDRDPPALLAPGRRVRFVRAERESVAASPASAAATRIDRREDGTAVEVVRPSLQLLVQDAGRPGFAALGVSASGVADRVAMHAANRAVGNVPAAAVLESVGGAVLRFHGAGVAAVTGATGTLTLTDADGTERTLLPGVPFATVDGDELTLGHPERGLRSVIAVRGGLAPAAALDSRATDTLAGLGPAPLTAGDLLPIGAAAVAAVEPDPVPRPLPAAGELVALEITLGPRDDWFTAAGIDALTAQEWTVTPRSDRVGIRLHGDVPLERAVGGELPSEGAVTGAIQVPPDGQPVLFLPDHPLTGGYPIIGALTDRSLDLAAQLPPGVRVRFTVKETS
>CP027434.1|AVL95962.1|404874_405675_+|putative-hydro-lyase
MAVLATPAQLADARAARVAHRAGHSAPTSGVAPGLTQANLIAVPADWAFETLLYAQRNPKPCPVLEVIEQGEVESRLAPGSDIRTDIGRYRIWRDGALVEEVSDATAAWDEHPDLVAFLIGCSFTFETGLVEAGIPIRHQELGRNVPMYRTAVDCTPAGRLRGEMVVSMRPIPADRVADAVQISGRTPAVHGAPVHIGDPASLGIADVMAPDFGDAPEIRPGEIPVFWACGVTPQAAIMASKPPFAVTHAPGYMFVTDVPDAEYRV
>CP027434.1|AVL95961.1|404108_404873_+|LamB/YcsF-family-protein
MATIDLNSDLGENVPDRIVSDDASMLEIVTSANVSCGFHAGSPEGIRETLAAAVAGGVVIGAHPGYRDYENFGRTKVDIDSATLQAHVEYQLGALLGLTAAVGGRVSYVKPHGALYNTIARDERQSKDVVAAIKAVDPSLVLLGLAGGVVLDVAERAGLAVAAEAFADRAYQPDGQLVSRTEEGAVLHDPTAVAERMVRLAADGVIRAIDGTDVAVSAQSICVHGDSPGSVAMAAETKRLLQAEGITIAPFAGV
>CP027434.1|AVL95972.1|418094_418769_-|coenzyme-A-pyrophosphatase
MSMHPQGARAELLAAAADHSWSVPIPPLADPGHAHDASVLILFGVLDRIPAPTVDAAVARDLDVLLQRRAPTLSSHPGQVSFPGGRAEAADADAVATALREAEEETGLDPAGVEVLATLPVIPLAASNHLVTPVLAWWQSPSRVVAVDHAETVEVVRVPVAQLLDPATRFTSTLSRAGRTFRGPAFDVDGTIVWGFTAMVLDALFDATGWTVPWDTAAERPIAL
>CP027434.1|AVL95973.1|418818_419187_+|hypothetical-protein
MARKIDIVDGRAALGAVRDAEAAGTKPARPELATAVRYLLQLLDEKAPGNSVEVRVPPFGAVQVIQGPRHTRGTPPNVVEMDAATWIAVATGAEPWADAATAGRIHASGTRADLTGVLPLRP
>CP027434.1|AVL95974.1|419183_419963_-|heme-ABC-transporter-ATP-binding-protein
MGVSPRLRGQGLTVRVGDGRAILDDAAIDIHAGEVHALVGPNGAGKSTLFGVLAGDVAPASGTVLLDGRPVAGTRPRDLARQRAVLLQENAVTFPFTVEQVVRMGRTPWARSPAAEEDDSAVAAAMATTEVTALRERSVPSLSGGERARVALARVLAQSTGILLLDEPTAALDLKHHEDVMRVVRTQAEAGVAVAVVLHDLNAALAHADRVTLLMGGRVSATGTPAEVLTAARIEEVYGQPVDVFPHPLTGVPLVVARR
>CP027434.1|AVL95975.1|419953_421027_-|heme-ABC-transporter-permease
MTGEVVTPTPTRHRGLRFATVVVALVIGLLVTGVASITSGQYDLSPTALLDVLLRGLGIDTAGTPAAATDDGVIYNLRLPRLVLGLLVGAALAVSGVLMQAIFGNPLADAGVVGVSSGAALGAAASITFGLATFGMWTTPAFAFLGGLTAVFSVYLLSRSGGRTEVVTLLLTGIAINAIAGAGMAFLTFLGTTSTREQIVFWQLGSLNGALWSNIQLVAPLVAIGIVVALIVAPGLDLFALGERTARHLGVPVELLRMVVIVTVALLVCAAVAFAGIIGFAGLVVPHLMRMLIGPAHLPLVIASALGGALLIAAADLVARTAVPLADLPIGMITSLVGGPFFLWLLVRTRRRSGGWA
>CP027434.1|AVL95976.1|421023_422133_-|hemin-receptor
MRRTPALLLAAALALGLAACAGADSGPGAAAPPVDDACPQASTPLADLDLVADVRAATGPSTACLASHAVAPVEDDTAPALPVTVTDSEGREVEITDTDRILPIDISGTIAATVFALGLGDQVVGRDASTQFPGTEDLPVVTKTGHTLNPEAILELAPTVVLTDTTIGPKEVRQQLRDAGIAVVVISSDRRIDTTDALVTEIATALGVPTRGTALSARLDAELDAAIAEIADVTPSAETDRARMLFLYVRGSANVYYIFGEDSGADSLIDAVGGVDVAEEIGWEGMKPMTAEALVAAQPDVLVMMTDGLESVGGVDGLIERIPAIAETPAGAHRRVIDMADAEILSFGPRSADVISALARTLYAPEPAS
>CP027434.1|AVL95977.1|422294_425741_+|hypothetical-protein
MNATAHTPSASTRLRVLLAALFSFVLVAAGAMVSSPAHAAAATVTAAVSSADTSGLTVQVRVEGLPDVTGVYAALIVSGTESGISAGGGYAAFALPFPSVQQGATSFTLQAPVASLDRTKTYEVLVWQQHTAPTAATIYGRGDVTVTSAQWDTVFGTTPVQPGETEPGETTPGETEPGETEPGETEPGETEPGETEPGETEPGETEPGETAPGETEPAPAEAAIEVFLADGTTPAAGARLQAGDEIIVKGTGYDPTANVGGRGVPIPSNLPQGTYVVFGNFASTWQPSQGAPSSARSVGAQAWALAEGVLAQVPTQYQGAIRAQWVDISPEGSFQVALTLKDTPATPGSYGVYTYPAGGVVNADQERSVALDYRIASGLTTTVKAATAEDGLTVTAAATKLGAVTGAYAALIEKGTEADVTAGGGFLAMQYVRGITGGGFTVDLTAAASALDRSKAYEVIVWQQHTMPNADTIYARSTVTVTDAQWNALLPSSGPTVTTAVTGATAADGLTVKVTAADLGAVTGAYVALIETGTEADVTAGGGFLAMQYVRNIGFGAFAVDLNAAAKNLDRSKAYEAIVWQQHTMPTADTIYARGAVTITDAQWRALLGEKPTEPKPPVTPKPPVTPTKPAATVPGGSLRWAISSSFTNYITGPIAQGTIAVSGGATRSGGQFQFGQTVGGDFDAASGRGSVVYRGAVRFTGHHGVLDVTVADPTIRITSASSATLSVTSGGAQVPFATLDLSRAVRTAAGGAVTYTAAPAALTDAGRDRVLSGYGTTLNPVSFTIGSVAAAPSGTTGTVAAAAVVPKSTLPTTAPTAAGIEVDEENLAALAAGKTATVSASGFRANEEDIKVVVYSTPVLLGTVTADAAGVVKWSGALPATLADGEHTLTFQGSVDRGLAFTLARATTEIGVCTVEGATLHWGYKESFRTYIEGIARGGWTLADVAYEYPAFVWSNGTGSLDDAAGSGLVTYGGGITFTGHDGALNTTLANARVELTGDAGYLVFDVTGTTQAGEAVAQEGVRLAEFALADAAVVDGALTLDAVPTTLTPAGASAFGTYEAGEELDPVSAVIPVDGACGTPAEEESEPEAEADAAVTAISAPVATEEAPVWPWIVGGLVVVALAATGGVLIVRRTRRGEPAETTTEV
>CP027434.1|AVL95978.1|425835_426171_+|potassium-transporter-Trk
MPSHDTHQTVEATVRRVPRYGVLMGIGVVLGVIAAGILTMVGSFEQSQALDVVYPPGQVFGFLLLWTVPIGLALGGVAGLVLERIARRHDRVVRVDRETVVDEDDTTTDRA
>CP027434.1|AVL95979.1|426167_426773_-|zinc-binding-alcohol-dehydrogenase
MADKPQWLIREDASVPVLVALALRQLLGIRAPLDLPSLRDLSVRAPDAPDASPEVEAQWQGYWDMTVEPRAHHSGVPLELIDGFDTLVALPATGAEALSTAIRPHAGTALRYANAAHDRYVGSMKSHTGGDAYRAYASAIAEFERDIGRRAHSFELNVQVLPLSQRGIWWIGDLTVAVTDGLRRDVVAFDSAIRPVIAELA
>CP027434.1|AVL95980.1|426924_427800_+|hypothetical-protein
MSQSNAEGAAGSGTTESPGTVRTAAHEAAGVADTAKGQAADVVETAKAEAGAVAHEAKDQVRDLYHQTKTELSEQAAVQQRRVADGLRSVGGELGTMAERSDGGVAADLVRQASTRIQGIAGWIGDRDPGSLLTEVKSYARAKPGTFIAVAALAGLVAGRLTRALSEGAAESASSGAASGSGSPSGAGAAAPAVPPRPVVAPATTPGAVPGSAGAAGVVGGAGTAENTTLGEPPLPTDGTVPGAPDGMSGIDAGTAPWGVTPRGETVDDGDTPLYDRTDAASRGTDEEGRP
>CP027434.1|AVL95981.1|427796_428219_+|phage-holin-family-protein
MTDATPTPSEQKAETTSLGDLLSEVTTDLSTLMRQELELAKAELKQSATRAGRGAGMLGGAGYGALMAVFFLSVALWWALGAYVTGLGWSAVIVAVIWAVIALVLFVMGRKQLKSIEGAPRTVDSLKRIPDAVKRNEENK

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Crispr_ID: CP027434_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027434_2

656075-656149

Orphan

Consensus_repeat	Method
CCGAGAGAGGTCGGCGACCCAGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027434_2

>merge|CP027434|2|656075-656149|CRISPRCasFinder
CCAGAGAAGGTCGGCGACCGAGAGAGGTCGGCGACCCAGAGAAGGTCGGCGACCGAGATAGGTCAGCGCCCCAGA

>CP027434|2|2|656075-656149|CRISPRCasFinder
CCAGAGAAGGTCGGCGACCGAGA	GAGGTCGGCGACCCAGAGAAGGTCGGCGA
CCGAGATAGGTCAGCGCCCCAGA

Protein	Signature genes	Signature genes Name	Protein_function
CP027434.1\|AVL96167.1\|654652_656002_+\|peptidase-M23	unknown	unknown	gnl\|CDD\|366703
CP027434.1\|AVL96158.1\|644618_645485_-\|metallophosphatase-family-protein	unknown	unknown	gnl\|CDD\|365906
CP027434.1\|AVL96168.1\|656175_656667_-\|inorganic-diphosphatase	unknown	unknown	gnl\|CDD\|376376
CP027434.1\|AVL96166.1\|653195_653954_+\|hypothetical-protein	unknown	unknown	unknown
CP027434.1\|AVL96159.1\|645771_647178_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367497
CP027434.1\|AVL96170.1\|657787_658378_-\|DUF937-domain-containing-protein	unknown	unknown	gnl\|CDD\|368733
CP027434.1\|AVL96164.1\|651024_651771_+\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|197775
CP027434.1\|AVL96169.1\|656768_657761_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|238950
CP027434.1\|AVL96165.1\|651770_652916_+\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
CP027434.1\|AVL96162.1\|648458_650279_-\|ATP-binding-protein	unknown	unknown	unknown
CP027434.1\|AVL96160.1\|647180_647930_-\|plasmid-mobilization-relaxosome-protein-MobC	unknown	unknown	gnl\|CDD\|368576
CP027434.1\|AVL96161.1\|648002_648419_-\|hypothetical-protein	unknown	unknown	unknown
CP027434.1\|AVL96175.1\|662661_663057_+\|dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|376737
CP027434.1\|AVL96177.1\|663589_664072_+\|DUF3180-domain-containing-protein	unknown	unknown	gnl\|CDD\|378650
CP027434.1\|AVL96172.1\|659207_661208_+\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
CP027434.1\|AVL96176.1\|663053_663593_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	unknown	unknown	gnl\|CDD\|238269
CP027434.1\|AVL96171.1\|658499_659051_+\|hypoxanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
CP027434.1\|AVL96163.1\|650743_650938_-\|helix-turn-helix-domain-containing-protein	unknown	unknown	gnl\|CDD\|225848
CP027434.1\|AVL96174.1\|661817_662627_+\|dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
CP027434.1\|AVL96173.1\|661209_661821_+\|GTP-cyclohydrolase-I-FolE	unknown	unknown	gnl\|CDD\|236472

Protein	Function_ID	Function_description	E-value
CP027434.1\|AVL96167.1\|654652_656002_+\|peptidase-M23	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	4.30406e-37
CP027434.1\|AVL96158.1\|644618_645485_-\|metallophosphatase-family-protein	gnl\|CDD\|365906	pfam00149, Metallophos, Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.	6.80261e-06
CP027434.1\|AVL96168.1\|656175_656667_-\|inorganic-diphosphatase	gnl\|CDD\|376376	pfam00719, Pyrophosphatase, Inorganic pyrophosphatase.	9.15545e-85
CP027434.1\|AVL96171.1\|658499_659051_+\|hypoxanthine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	2.08956e-81
CP027434.1\|AVL96159.1\|645771_647178_-\|hypothetical-protein	gnl\|CDD\|367497	pfam03432, Relaxase, Relaxase/Mobilisation nuclease domain. Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation. The relaxase, in conjunction with several auxiliary proteins, forms the relaxation complex or relaxosome. Relaxases nick duplex DNA in a specific manner by catalyzing trans-esterification.	1.55062e-16
CP027434.1\|AVL96170.1\|657787_658378_-\|DUF937-domain-containing-protein	gnl\|CDD\|368733	pfam06078, DUF937, Bacterial protein of unknown function (DUF937). This family consists of several hypothetical bacterial proteins of unknown function.	1.63614e-07
CP027434.1\|AVL96164.1\|651024_651771_+\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	0.000273139
CP027434.1\|AVL96169.1\|656768_657761_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	1.15652e-64
CP027434.1\|AVL96165.1\|651770_652916_+\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	6.05838e-20
CP027434.1\|AVL96160.1\|647180_647930_-\|plasmid-mobilization-relaxosome-protein-MobC	gnl\|CDD\|368576	pfam05713, MobC, Bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region. The absence of MobC has several different effects on oriT DNA. Site- and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency of mobilisation. The localized DNA strand separation required for this nicking is less affected, but becomes more sensitive to the level of active DNA gyrase in the cell. In addition, strand separation is not efficiently extended through the region containing the nick site. These effects suggest a model in which MobC acts as a molecular wedge for the relaxosome-induced melting of oriT DNA. The effect of MobC on strand separation may be partially complemented by the helical distortion induced by supercoiling. However, MobC extends the melted region through the nick site, thus providing the single-stranded substrate required for cleavage by MobA.	4.50111e-06
CP027434.1\|AVL96172.1\|659207_661208_+\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
CP027434.1\|AVL96175.1\|662661_663057_+\|dihydroneopterin-aldolase	gnl\|CDD\|376737	pfam02152, FolB, Dihydroneopterin aldolase. This enzyme EC:4.1.2.25 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	1.40186e-44
CP027434.1\|AVL96176.1\|663053_663593_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase	gnl\|CDD\|238269	cd00483, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.	1.2747e-48
CP027434.1\|AVL96177.1\|663589_664072_+\|DUF3180-domain-containing-protein	gnl\|CDD\|378650	pfam11377, DUF3180, Protein of unknown function (DUF3180). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	5.64598e-18
CP027434.1\|AVL96163.1\|650743_650938_-\|helix-turn-helix-domain-containing-protein	gnl\|CDD\|225848	COG3311, AlpA, Predicted transcriptional regulator [Transcription].	9.07092e-10
CP027434.1\|AVL96174.1\|661817_662627_+\|dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	2.76096e-95
CP027434.1\|AVL96173.1\|661209_661821_+\|GTP-cyclohydrolase-I-FolE	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	8.48555e-81

>CP027434.1|AVL96167.1|654652_656002_+|peptidase-M23
MNEKTTQDAALAASADCGCAPTPTERRALFGDGISRRGALGLGALSVVALSAFGISSGVTAAHAASYPSWDDVQKAKQNEASKAAEVKRIEGLIQSLTQKVSETQAAAEVASTEFYNAQQAYFAAIAEADSLQEKADAQAAVADESARKAGQVAAQLYRNGGDDTSLELFFAGSAANADELLARLGSMDKLLEYNQTVYNDAVAARNSAQSLSDQAVVARDERDRLQKIAEEKMVAAQQAADAAQAALDEQSANLATMQAQLAALKDTTATTVAGYQKGVEEREKERKRREAAEAAANAGGNSGGGGTPGSGGWVRPHGGYRSSGYGPRSQQCNANGCSSSWHYGVDLANGCGAAIYAAHSGTVDAAFYNGGYGNYVRIQHGGGIATGYAHIKPGGFAVRNGQWVRAGQVIAYAGNTGGSFGCHLHFEVYINGRYTNPIDFMASKGISV
>CP027434.1|AVL96166.1|653195_653954_+|hypothetical-protein
MGVELEVPLDDEEIDGFAVVESISIMYLAAEALLRLYFAHVEPEPCPPLKLSSLTSFAKFKQMAGDLLTSPPRNELLREVFRGRLDAPAEVSAEAWTEDADVLRFLLTRAAALLAREANVYNSTKHGLAVQPRKSGLRLGSEEDPNGVIIDHHGPSIRFLSKGPSAEEGVQQWRETIQFAFPSINLAVASAFADEIDAIHAVAKARLTGEQGSVTIRQRALIDHLRAVPFASNYTGLLSLGMHRDFGVRIGR
>CP027434.1|AVL96165.1|651770_652916_+|site-specific-integrase
MARPRMAIGTYGTIHVAEVQPGKWRARTRYRFADGKSRQIEKHAPSKAKATAALRHALTTIEADRGGELKPATHLRALGQRFLESRRELGRSEGTLETYGYAVTAHIAPRIGDLSVAEATPERLQKFLNAVEKEAGPGAAKNCRSALSGMLGLAVRNGALSHNPVRELERVTQRKKKGSTAIPLDELPMFLQRVREDEKLNEWDTVDLITFMLASGWRVAEVCALEASAIDFAAGTASVVAQNVRVKGRGIVRQEFAKTDKSARTTHLPEATMLLLHKRHERLRADTNLIFPTPLMRPRDPSNTQRELRDRRDGLGYPGLSTHAFRKSVATILDKAGLSATEIADYLGHENPSMTQDVYMNTIKGSTKAAGIMGQKLDGLI
>CP027434.1|AVL96164.1|651024_651771_+|helix-turn-helix-domain-containing-protein
MESMAYAEAVGGFLAAYRRRHGITLEAIATVGRDYGATWSLSSVQAIERGKAAPTVPTLLTLALALGKLSGEPLRLADLLGAAELLERPYELREDQPVRREWVNRVLSGAPIALEDGDYAHVGAAPIGGDHEWDEELEMAALEHMRVHGRKSESYDQVDAQWGAMTEVPDRDTRQSARRPSVSLAESRAAKKLGIRPPLLQQYAARLWGHSLEVEALLRAGEDSTPQARGRVTRVLIDELRASTDGEV
>CP027434.1|AVL96163.1|650743_650938_-|helix-turn-helix-domain-containing-protein
MTQTTNTLLDVHDLSAQTGMSVSTIYRKRSLGEPLPRAVKIGAAVRWRQADVDRWIEEQLEPAM
>CP027434.1|AVL96162.1|648458_650279_-|ATP-binding-protein
MTTTSVPEDRDIPEALGKRSTAQQLVELALDHYDLHVDTDGKPFGVRKGGHVAIPLLGSRRSVRKELGGMYRRRTARTASQNALTEAMSALEYEAEESFEPIKLHLRTARPSDDEIFIDIGDRSEQVIRVTAAGWEILDGDDDLPVLFRRTAVTAPLPVPARGGNLDALWEFVNLPASDRGLIIGWLVAATILVGLPCPALALLGEQGTAKTSSARRLFSLFDPTTAPVRRPPNDADRLLHAGAHSRGVVFDNMSSMPRWLSDGLCRFVTGEADVDRALYTDDDVRIMQVQGVLGFTSIDIGVLNGDLAERCVWGDLEVIPADRRRSERELNSAWNASYASMVGALLDLVVLTLQQLPVVKLGNKPRMADFAEILAALDHATGSDTLSRYRRAQDSVAEDIVSTDQFLVAITETIKRRWTGTGKALHELLRRPSDDRYWPEPRGMSGKLRRVAPDLRKAGWQIDEIKPDPTTKRSKTWVLVPPDSAISDADLASVKLTREFVAEDVRAWIARFMANGATASCATDHGSAASSGFPITCRTPGCTAGWRSEWDTPLQRSRALTSRLADELTALGISVADLDQYVGSDPFAPPGRGEETVAPPKTEPR
>CP027434.1|AVL96161.1|648002_648419_-|hypothetical-protein
MRRTRSQLRAAQIAALQAEQDAYDKNVNDAIKVAAFARCDAVEQLYELLDVQPEPPIIRDGKHGRYEVTSDKDEAKRAARLIEAVTVLLSIEEQPTTQPVGSDRQVPAQAAERPPQAASPALVATTSSTPTAVKQPAA
>CP027434.1|AVL96160.1|647180_647930_-|plasmid-mobilization-relaxosome-protein-MobC
MGFLRFGRWRHDLCVEAGAFIRVSGRRPDQGVSKDRSAAICLTDKLLAVICVVWDHPRGAGKQRPRLHKEPSEGDDLMTRTGKASEATPRRPRKRVVNFAKRRTLRFSDDEERAVDDVRRALAKSSGRDLEEVSFSEALRLLITDREGAAEVEARALAIERQGPNVTDWGLADISDRLGYELGPIRNHIAHIGGNLNQIAKRLNIGDPVTAGEVSEALLTVAELRDVPDDIEKRIARLVDHGLPPRGTV
>CP027434.1|AVL96159.1|645771_647178_-|hypothetical-protein
MPVVVASSTRSADALINYALDDKPEQDGERYVMASGVGGMLVSVAKQQMRDVRKKWGKDKPGAFVQAYHVIQSFAKDELDPEEPDDWLTAQKLGTALAEERFPGRQVLVVTQRDGRTGCVHNHLVANSIETKTGRSLNSSVVTHARLVEAHERVLEQRGFEQRADLKQAFSDANERFERGEPSGLRRAGSTADSELREWQRHIIWETECDLADEFGAPRNKQPFSLTVLRASIENTLADPAVVDWDSFVEVGRTRGVQIEQRGKKGRGISYGMLRENPDRTPADPTPSDRRRCTTLGTAFERDAVETAFARNSAVTLSVPQHTTVERRLSPKKRMMIALDEATQEANRAAQRLVATALSNADAMTSEHENSGAHAPTELPAVPGTMGLSELRETQPRIADPEEPETEVTVPDYRPHDVEQPRSARPQANTGENQETSPKPRPLRLRFPALFEEAELSAPDHQERSIGD
>CP027434.1|AVL96158.1|644618_645485_-|metallophosphatase-family-protein
MQIHETADSFDLPDERVWVVGDLHGNAGWIQTLLPAMRRHDPSLRTILQLGDYGFEHAQPGTGPVDYWAKRTGIERVLVTPGNHEEWNHITPAQESASGMAIRVSDVVWLIPRPFRFQIAGREVLSLGGASSVDKAFRTAGKDWFEDELITEPMEAAAIAGGPADLMLTHESPAIAVPEVQRLLTNNPHDFPPEALAVSAAQRERVQRVSDAALPRLHMHGHMHVYGKFEREDGRTVVSLDRDTFACNAGVLDLAGLAFSPLPLNEIRGGRRRYKHRADQGDGAVVRS
>CP027434.1|AVL96168.1|656175_656667_-|inorganic-diphosphatase
MGAHDAVIEIPRGSRVKYEVDHETGRVHLDRVLYTTFGYPADYGYFDNTLGEDGDPLDVLVLLDHQIYPGVVVEVRPVAVLKMSDEAGGDDKLVAVLSKDPRWAHIQDIDDVPEYTKKEIAHFFEHYKDLEPNKWVKVDEWGNAAEAQRILDEAIVRFGEQGH
>CP027434.1|AVL96169.1|656768_657761_+|tRNA-lysidine(34)-synthetase-TilS
MPSLDPAVAEIRLAVRTALADLPEGSTVVVAVSGGADSLALAAATAFEAAKVGVRATAVTVDHGLQQGSAEVAAETGRIAGRLGLEALVLRVEVDGDGGPEAAARDARYRVLRDAAGEIGARAVLLGHTLDDQAETVLLGLARGSGATSLQGMAPDREDDDGLRWLRPLLRVRRETTRAFCGAAELQPWEDPHNTDDRYTRVRVRRHVLPVLETQLGPGIAEALARTAEQLREDAEAFDEMIHETIEDIVEHAEAGISVSVAALAANPAALRNRIIRLVVDSEFGASLSRAQTIEVARLVTDWSGQGPIDLPGCAAVRQGGRIVFTAATR
>CP027434.1|AVL96170.1|657787_658378_-|DUF937-domain-containing-protein
MATHDILSQVPLDDIAQKLGVSRDEAKVAVEQGGAVLLGGLAKNAESSEGSAAIEKALGKHRGASSPATVDDIDQEDGEKIVSHILGGKEKEVTKELTESKATPGIDFGKLLPILAPIVMGLIANATKDKTAKADAGAEGSGGIGDVIGGILGGGDSGSGGGLGDVLGGLLGGGKSGSGGGIDLGGILGGLFGGKK
>CP027434.1|AVL96171.1|658499_659051_+|hypoxanthine-phosphoribosyltransferase
MRAAEIQDDLAQILVTEEEIHAKLDELAAQVAKDYEGKDLILVGVLKGAVMVMADFARALPFHAPMDWMAVSSYGASTKSSGVVQIRKDLDTDLHGKHVLIVEDIIDSGLTLSWLLENFESRGAESIEVLALLRKPEAAKVEIDCKYVGFDIPVEFVVGYGLDYAERYRNLRDVAVLAPHVYS
>CP027434.1|AVL96172.1|659207_661208_+|ATP-dependent-zinc-metalloprotease-FtsH
MDVKKLTRNPLIYVALIGVLLFGGFLLISNLGAPKQITTQEGLELLSGKTVTEVVTTDGDQRVDMTLSKPFEGSENVQFYYVEARADEVVSAIDAAAPKDGFNDAVPRATWFDGFLSLLLPLVLLGLLFWWLLSSMQGGGGKVMQFGKSKAKLVNKETPTVTFADVAGADEAIEELHEIKEFLQDPAKFQAIGARIPKGVLLYGPPGTGKTLLARAVAGEAGAPFYSISGSDFVEMFVGVGASRVRDLFSQAKENAPAIIFIDEIDAVGRHRGAGMGGGNDEREQTLNQMLVEMDGFDPNANVIVIAATNRPDILDPALLRPGRFDRQIGVDAPDLKGRQKILEVHSKGKPLSKNVDLEVVARKTPGFTGADLANVLNEAALLTARSNAQLIDNRALDEAIDRVIAGPQRRTRVMKDKEKLITAYHEGGHALAAAAMNYTDPVTKITILPRGKALGYTMVLPLDDKYSVTRNELQDQLTYAMGGRVAEELVFHDPTTGASNDIEKATSIARKMVIEYGMTTQVGPVKLGTEGGDMFVARDMGRGREYSEKVAERVDAEVRALIEQAHNEAYAVLSENRDILDRLALALLEEETLDHNRIAEIFTEVKKLPERPLWLSSEDRPVSERPPIEVPKKDVSLAASVEAPTAPPRPQQGSAGAGNPRPATA
>CP027434.1|AVL96173.1|661209_661821_+|GTP-cyclohydrolase-I-FolE
MTVDKGRVERLTRELLEAIGEDPDRPGIKQTPSRMAELYAEFFAGVGEDPAEPLAHTISVTRGPAPDTLPSGAVLLRDIRFRSVCEHHLLPFAGHAHIAYLPGEQVVGLGALVRVVEILAARPQVQERLGEQIADTIAENLDARGVLVVLDASHGCVTMRGGRQTEASTLTIAARGVYTDPVARAELVTLIGMTVPGAGTSRA
>CP027434.1|AVL96174.1|661817_662627_+|dihydropteroate-synthase
MTGIWGIVNVTPDSFSDGGRYLDADRAVAHGLRLRAEGASVLDVGGESTRPGAERVGVDEEQRRVLPVVEQLAAAGAVVSIDTLNASTAVAAVRAGARIVNDVSGGLADPDMRAAVAESGADFAIGHWRGFSADMYANADYRRVAREVAGELRERIGEAAAAGIAPSRLIVDPGIGFAKAGAQNWDVLRGLDEIVGLGFRVLVGTSRKRFLADVLQEAAPGGDGVSEERRDLATAVTSALAMRAGAWAVRVHDVAATRDALAITRAWEG
>CP027434.1|AVL96175.1|662661_663057_+|dihydroneopterin-aldolase
MDFLDEIVLTGLTVFGHHGVYPHERENGQEFTVDLRLRLSLEQAAASDEVADTVHYGELAERVAAVVAGEPVNLIETLAERIADVALGDRRVQQVTVTVHKPQAPIALTFDDVAVTVHRTRAPESLEDITT
>CP027434.1|AVL96176.1|663053_663593_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-diphosphokinase
MSRNLTRPPEVPGPRAPRPETVAVVALGANLGDREDTIRAAAARIGRLPLVSDVRLSRLFETVALRVDGPDPDAPGYVNAVALVTTRLAPEILLGMLHAIEDENGRVRGERWGDRTLDLDLIAYGDVVSDDPRIQLPHPRAAERLFVLEPWLDIDPDAELVGRGRVADLAADLRARGEG
>CP027434.1|AVL96177.1|663589_664072_+|DUF3180-domain-containing-protein
MKRTSAGLLAVLALVGAGAGFILDQMLTATGRATFTPSLFLPVLLVLIAGASLGVAWPVRRSVRSGVRIDPFRALRAATLARASSLLGAILAGFGAGLLAFLLTRPIDPPIGSTVAMVALIASAVVLVIAALVAEQFCTLPKDPDDSEPRDRAPEPGGGH

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Click the colored protein region to show detailed information

Crispr_ID: CP027434_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027434_3

3306099-3306211

Orphan

Consensus_repeat	Method
AAACGACCCTTCCGACGGACCCCGCGGCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027434_3

>merge|CP027434|3|3306099-3306211|CRISPRCasFinder
AAACGACCCTTCCGACGGACCCCGCGGCCCCTCTTTCATCCCGCACACAAGAAGGCCAGGGACCGACCGCCAGGCGGGATCAGAAACGACCCTTCCGACGGACCTCGCGGCCC

>CP027434|3|3|3306099-3306211|CRISPRCasFinder
AAACGACCCTTCCGACGGACCCCGCGGCCC	CTCTTTCATCCCGCACACAAGAAGGCCAGGGACCGACCGCCAGGCGGGATCAG
AAACGACCCTTCCGACGGACCTCGCGGCCC

Protein	Signature genes	Signature genes Name	Protein_function
CP027434.1\|AVL98481.1\|3295838_3296756_-\|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223472
CP027434.1\|AVL98493.1\|3308475_3309081_-\|dCTP-deaminase	unknown	unknown	gnl\|CDD\|234753
CP027434.1\|AVL98497.1\|3312682_3313492_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|187576
CP027434.1\|AVL98487.1\|3301856_3303263_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225179
CP027434.1\|AVL98485.1\|3300057_3301233_+\|DUF1343-domain-containing-protein	unknown	unknown	gnl\|CDD\|377768
CP027434.1\|AVL98884.1\|3313563_3314568_+\|FUSC-family-protein	unknown	unknown	gnl\|CDD\|379231
CP027434.1\|AVL98488.1\|3303309_3304227_+\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
CP027434.1\|AVL98486.1\|3301288_3301786_+\|DUF3253-domain-containing-protein	unknown	unknown	gnl\|CDD\|371633
CP027434.1\|AVL98495.1\|3311470_3312031_-\|deaminase	unknown	unknown	gnl\|CDD\|223340
CP027434.1\|AVL98490.1\|3306346_3306994_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
CP027434.1\|AVL98883.1\|3304233_3304602_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|197670
CP027434.1\|AVL98484.1\|3299188_3300055_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
CP027434.1\|AVL98496.1\|3312027_3312642_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377941
CP027434.1\|AVL98494.1\|3309415_3311446_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225272
CP027434.1\|AVL98482.1\|3296755_3297712_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224096
CP027434.1\|AVL98498.1\|3314624_3315278_-\|porin	unknown	unknown	gnl\|CDD\|238204
CP027434.1\|AVL98492.1\|3308000_3308474_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274311
CP027434.1\|AVL98491.1\|3307066_3308068_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
CP027434.1\|AVL98489.1\|3304916_3305672_+\|hypothetical-protein	unknown	unknown	unknown
CP027434.1\|AVL98483.1\|3297767_3299051_-\|sugar-ABC-transporter-sugar-binding-protein	unknown	unknown	gnl\|CDD\|270452

Protein	Function_ID	Function_description	E-value
CP027434.1\|AVL98481.1\|3295838_3296756_-\|carbohydrate-ABC-transporter-permease	gnl\|CDD\|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.64871e-75
CP027434.1\|AVL98493.1\|3308475_3309081_-\|dCTP-deaminase	gnl\|CDD\|234753	PRK00416, dcd, deoxycytidine triphosphate deaminase; Reviewed.	1.82297e-92
CP027434.1\|AVL98497.1\|3312682_3313492_-\|hypothetical-protein	gnl\|CDD\|187576	cd05266, SDR_a4, atypical (a) SDRs, subgroup 4. Atypical SDRs in this subgroup are poorly defined, one member is identified as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is related to, but is different from, the archetypical SDRs, GXGXXG. This subgroup also lacks most of the characteristic active site residues of the SDRs; however, the upstream Ser is present at the usual place, and some potential catalytic residues are present in place of the usual YXXXK active site motif. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.71064e-48
CP027434.1\|AVL98485.1\|3300057_3301233_+\|DUF1343-domain-containing-protein	gnl\|CDD\|377768	pfam07075, DUF1343, Protein of unknown function (DUF1343). This family consists of several hypothetical bacterial proteins of around 400 residues in length. The function of this family is unknown.	4.96974e-142
CP027434.1\|AVL98487.1\|3301856_3303263_+\|MFS-transporter	gnl\|CDD\|225179	COG2270, COG2270, Permeases of the major facilitator superfamily [General function prediction only].	5.07393e-89
CP027434.1\|AVL98884.1\|3313563_3314568_+\|FUSC-family-protein	gnl\|CDD\|379231	pfam13515, FUSC_2, Fusaric acid resistance protein-like.	1.48947e-13
CP027434.1\|AVL98498.1\|3314624_3315278_-\|porin	gnl\|CDD\|238204	cd00333, MIP, Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.	1.6408e-28
CP027434.1\|AVL98486.1\|3301288_3301786_+\|DUF3253-domain-containing-protein	gnl\|CDD\|371633	pfam11625, DUF3253, Protein of unknown function (DUF3253). This bacterial family of proteins has no known function.	5.2929e-21
CP027434.1\|AVL98495.1\|3311470_3312031_-\|deaminase	gnl\|CDD\|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	6.74659e-09
CP027434.1\|AVL98490.1\|3306346_3306994_-\|transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	0.000722712
CP027434.1\|AVL98883.1\|3304233_3304602_-\|hypothetical-protein	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	4.16702e-16
CP027434.1\|AVL98484.1\|3299188_3300055_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	4.52485e-73
CP027434.1\|AVL98483.1\|3297767_3299051_-\|sugar-ABC-transporter-sugar-binding-protein	gnl\|CDD\|270452	cd14749, PBP2_XBP1_like, The periplasmic-binding component of ABC transport systems specific for xylo-oligosaccharides; possesses type 2 periplasmic binding fold. This group represents the periplasmic component of an ABC transport system XBP1 that shows preference for xylo-oligosaccharides in the order of xylotriose > xylobiose > xylotetraose. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.46714e-56
CP027434.1\|AVL98496.1\|3312027_3312642_-\|hypothetical-protein	gnl\|CDD\|377941	pfam07920, DUF1684, Protein of unknown function (DUF1684). The sequences featured in this family are found in hypothetical archaeal and bacterial proteins of unknown function. The region in question is approximately 200 amino acids long.	2.06036e-52
CP027434.1\|AVL98494.1\|3309415_3311446_+\|hypothetical-protein	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	2.01969e-56
CP027434.1\|AVL98482.1\|3296755_3297712_-\|ABC-transporter-permease	gnl\|CDD\|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.38688e-72
CP027434.1\|AVL98492.1\|3308000_3308474_-\|hypothetical-protein	gnl\|CDD\|274311	TIGR02813, omega-3_polyunsaturated_fatty_acid_synthase_PfaA, polyketide-type polyunsaturated fatty acid synthase PfaA. Members of the seed for this alignment are involved in omega-3 polyunsaturated fatty acid biosynthesis, such as the protein PfaA from the eicosapentaenoic acid biosynthesis operon in Photobacterium profundum strain SS9. PfaA is encoded together with PfaB, PfaC, and PfaD, and the functions of the individual polypeptides have not yet been described. More distant homologs of PfaA, also included with the reach of this model, appear to be involved in polyketide-like biosynthetic mechanisms of polyunsaturated fatty acid biosynthesis, an alternative to the more familiar iterated mechanism of chain extension and desaturation, and in most cases are encoded near genes for homologs of PfaB, PfaC, and/or PfaD.	0.00871792
CP027434.1\|AVL98488.1\|3303309_3304227_+\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.49533e-26
CP027434.1\|AVL98491.1\|3307066_3308068_+\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	7.68349e-10

>CP027434.1|AVL98489.1|3304916_3305672_+|hypothetical-protein
MNTTADSTSDNTSRPFGFWLKAVDRLMAHDFATAFAAEGATRRDWRLLNVVDGTVPVRRPLHPHKLHDLVDRGWVEADGDGWALTDEGRAAKERLGATVDGIRAKVADAVSDEEMATTLAALEKIARAFGWDEETPLPRKRRPGFGFGPRHGFGRGHGFGPGHGFGPGDFEPRRGFGAGHGFGPGDFEPRHGFDRHDGEEDGGYRGRGHHDGHAHRDHGHARRSHGHRAQRMAERAFERGFDAGFRHGHAA
>CP027434.1|AVL98883.1|3304233_3304602_-|hypothetical-protein
MPPWMVDGGRLGGPARLRMLEALAAAPEPLSVSALGQAIGVDQPRASRLVQQGVQAGFVRREADPDDARRTRIALTDEGRRLARGMRGERRELLGRALESFTAEERTELARLLTKLADNWRA
>CP027434.1|AVL98488.1|3303309_3304227_+|cation-transporter
MTVVLAFLANILVAIAKTVAAVITSSASMVAEAAHSWADAGNEVFLLIADRRGAKTKDARHPLGYGRNAFVWSLIAAFGIFTAGSIVSIMHGIQELSDTGPVESPVVAYIVLGIAFVLEGASFTQAMVRSRRLARERGSSTWDFVLETSDTTLRAVFFEDSAALIGLVLAGGSILLHQLTGVAAWDAIGSILVGILLGVVAVILIGRNIAFLVGTSVSPALRSRVGTALLGMDDIERVTYLHIEYVGPNRLFLVAEVDLAGDAREHDVARRLREVERRIEAHDAVETVVLSLSVDDEPSLDFARV
>CP027434.1|AVL98487.1|3301856_3303263_+|MFS-transporter
MTSPDPAAGAPEPVATANSGAVAVVGLDLRGDTPAPRKQVYSWALWDWATQPFNTVILTFVFTALYLVSASFLPPEIAALDPSDPVRVAAEADLASGLGLGSTIAALGILLLAPVLGQRADAAGRQKLWLGIGTGALILCMLGLWFVEPQPALFWLGVALISAGSVFGEIAAVNSNAMLIGIANPKNVGRISGLGWGFGYLGGIIALVIVVLLDTFDWFGMSTDNGLAYRLIAVGCAVWAIVFSIPIFLNVPEPSLGRPERKVGFFRSYVLLVQDVIGLYRDPQTRSTFWYLLASAVFRDGLGGVFAFGAIIGTAVFRFGTQDIIVFGIAANLVAGVSTIIAGRLDDRLGPKRIILGSIGSMIVAGLAVFLLRDAGSLVFWIGGLVLCAFVGPAQAAARSFLARVTPAGREGEIFGLYATTGRAASWMASAAWTVLIVATSQTAYGILGIVIVLIIGFLLLLPVKAPR
>CP027434.1|AVL98486.1|3301288_3301786_+|DUF3253-domain-containing-protein
MAGMTDEGPAQTADGHHIVVNGRRWRATDPSIPENLRQELVDELMAARRAVKAAEPDARRRVQDAKTALGERGAPWWEEPSAAQAEERIAATMRALTRKRADSSICPSDVARAVGGAEWRDRMPDVRRIAADLASREVVVVTQKGEQVSIADVRGPVRIRRGPAL
>CP027434.1|AVL98485.1|3300057_3301233_+|DUF1343-domain-containing-protein
MQLGIDRLLHDDLTQPQRDRLRGARLGMVTSDLALTSTLARGRAGLADAGFPLTLLFGPEHGLDGRAREGELIGDLRDTPTGLPVRSLYGADVRPAAADLADLDVVLVDLPDVGARFYTYIWTMSHVLEACADAGVAVMVLDRPNPLGGRLEQAEGPMLDEAANSLVGRWTMPVRHGLTIGELARHWVRTRGIDVELHVVEVQGWTRDQTTLGRQELTWMPPSPNLPSAATILLYPGTCLAEGVNVSEGRSTAVPFRVVGAPFIDAEEYTTAFVELALPGVTASPYGFTPLVRDHAGEACQGLLLHVTDPAAFQPVHTGVRLLSLLATLYPEALTERALVPMPGESDWSPLEKLFGVEGAFRRITAGEWDEPESLAVPDWPGLVDADLLYR
>CP027434.1|AVL98484.1|3299188_3300055_+|MurR/RpiR-family-transcriptional-regulator
MPNSVVTAIHQRLSALTPTERRIAERVLAEPQAVLENSITRLAEECGVSVASVARFTRSLGFPGYPDLRIALAGELTRSASERERFQVSAGDVSRHDDAATTVRKIAFAEAEAIERTARQLDIAELERCVAAVRGARRIDIYGAASSGLAAQDLEQKLHRAGLVAQARTDHHLALTGAALLDDRDAAIAISHSGRTLEIVQAAEVAAAAGATTIAITNNPRSPLARACAHTLVTAVSESTFRSGAMASRIAQLAVLDFLYTRIAQADYDRISANLQRTHDAVTAHRID
>CP027434.1|AVL98483.1|3297767_3299051_-|sugar-ABC-transporter-sugar-binding-protein
MRNRPVRLALTGGILVAGLAVAGCAPAASSGDGQDDVTLTIWSWQASSSPKWEAVFDAYEESHPGVTIEFEGFQPTEYNQILATGLEGSDGPDIAMLRAYGGVQSAIQSEQIVPIDDIVDGLDQFDPTVLRAAQGKDDGKTYGVPFAYQTMQMFYNKTMFDEMGLEEPTDWDEFIELQETLLKEGVTPMALGAREDWVLPMFHDIVGSAHYGGAAFEEKVLAGDVDFTDPAYVSSLQIVQDMQKYLDKNVNAIAVADAVLQFTSGQAAQWPGGSFDLPTFQSSAPDTEWGVYEVPPSPDSALDHAVTPGYADGSFGINAASENQEAATELLNWMTTKEFGQLVADEVDQFSALPGVEYSDPLMQEMNEQYTANPAPYLLLVDFRYGDPTGTAVLGPDIQAMFLGQKTPEQLGADLQSGISTWFTPSS
>CP027434.1|AVL98482.1|3296755_3297712_-|ABC-transporter-permease
MALTLPVRPPKSRRPRTGIALSTPTAALFVLPAAVLFAVLILYPMLAALSYSFFDWQGTKQGGFAGIGNYLTLLTKEPYASELWNAFGHNLLLFVGALVFQNSLGLGIATLLHRRKRTKRFFQTIFALPYLVSPMVIGYLWSLMLSPLFGPVNAILRGVGLESLALPWLGDPQLAIWVIVLVSAWQWIGFPILLYGAALGGIPEEIEEAASLDGATAAKRFRYITLPMLTPTIGIITVLTFIGSMEAMAIPFALAGSNGAPAGSTDVMMLLFYRTAFESGNPNSIGVSSALATVLFIFIMVISVVITTTMRRAERKLF
>CP027434.1|AVL98481.1|3295838_3296756_-|carbohydrate-ABC-transporter-permease
MSTALDTRQEPTTEAIVSGRTSAPRRRSRRTNDTPFVGRLLANVFLWGYALVAIGPLLLMVNNSLRTQQQIATEPLGLPVPPTFTSFQNAWITASFDTYFVNSITVTVGSVIVTTVVSVLAAYAFARARAKFFRGIEAVFLSGLMLPVHLAILPLFYLLDALKMTSNVFSLILVYGALGIPFTTFVLTVFFRALPIELEEAARIDGAGPLRTFLQILLPLVRPALATVIVFRFVPVWNDFFYPLILLRDRDSYTLPVGLTRFFGEYSTDWPQLFAGLTIATIPLVVLFLLATKQIINGLTSGMSK
>CP027434.1|AVL98490.1|3306346_3306994_-|transcriptional-regulator
MVDGVVQDGRRARGDASRRIVLESATDLASVEGLDGVTIGRLATASGSSKSSIATLFQSKEGLQLATVAAARDIFVERIIEPARVQPRGAHRLAALLHNALVYSKDRVFTGGCFFAATAADVDSKPGPVSDAVRAALVDWYGYIEAQLRFAAAEGEVGAADVEVLAFELVALNEQANARSLLLRSDRPYALAAAAMRSRLRDAGAPDTALALLAL
>CP027434.1|AVL98491.1|3307066_3308068_+|alpha/beta-hydrolase
MPSASSLLVRHLPTVGRLSPRLAGDLAYRLFFSTRPRMAVRSADAATHDDARRGSLLVRGIPVTTYTWGTGPRTVLLLHGWRGRASQFAPLVRELVAEGFRVVAFDAPAHGSSGGRHTDIRDWVDAAEQLDRTHGPFSTLIGHSFGGLAALTVARSSGSVPAVAVVAGAAAPEAFLAQFVGDLRLDAATADRLRTRFHRRLRLDPATAAERYDAAAHPLPAGTALLIVHDRGDRRMPDHDALRLHAAHPGRSRLVRTVGLGHTRVLSADPTLDAVVALVTGGLEAVDALGTASGRAAIDAAPADPSAALRSPTPGSTGSPRSGRRPRTAVRQW
>CP027434.1|AVL98492.1|3308000_3308474_-|hypothetical-protein
MSDASGTGSDESALPGGAALPEDPGLEIAPADAVIPPADAVIPPPPPETPIPEGLLTAPDAAGDALPAPTRRSERSRPTPAILQGEQPAAAADDWAQRSIAPEVADTGSYRMLAVVVFVVLFLLLAAAVVTLVVLITTVGLPFAAADPSAGFLSTRV
>CP027434.1|AVL98493.1|3308475_3309081_-|dCTP-deaminase
MLLSDRDIRAELASGRVGLEPHAPEMIQPSSIDVRLDRYFRLFDNHKYPFIDPSVDQPELTRLIEVDPDEPFILHPGEFALGATFEQVTLPDDIAARLEGKSSLGRLGLITHSTAGFIDPGFSGHVTLELANVATLPIKLWPGMKIGQLCFFRLTSPAENPYGSGPYGNRYQGQRGPTASRSFQNFHRTDVGVTDIGAVGG
>CP027434.1|AVL98494.1|3309415_3311446_+|hypothetical-protein
MTSRGGAWITLGAVLLIMTTLFGLFGSAKAPAANEQAPAGSESARTSALLAEFPNADRQSVIVVASRDDGATLSAPDVDALESLLPVLGTHADADPTGPLVSEDEKAAVLVTPIAVGQTSTDTAAVIAALRADIDEHAPDGMTLLVTGGPAFGADIAASFEGADFTLLLVTVLIVAVLLIVTYRSPVLWLLPLAAVGLADGLAGRLTAAAGSAWDLQFDAGIISVLVFGAGTNYALLLISRYREELTTTTDHRRALSTAWRGTAPAILASNLTVVLALLTLALAVIPGTHGLGVSSAIGLLVALASVLFLLPPLLAVCGRKVFWPFVPRPGAAARRGGVWRSIATRVVSRPVVSLLGGAALLAVMTVGLVGTTVGLDQVDKFRVPSESATGLEVLSNHFPAGEAQPILIVTDSGEADAVLTAARGVEGIVRATPVGTTHDERLTKILVTSEYAPSTDESLAQITELRDAVHDVPGAGAVVGGAVATDLDARAGNLADLGVVVPLVLAVSFLVLAFLLRSLVAPLLLLAVNVASAVAAIGAGAWLSRVLFGQHALDLPVPLLAFLFLVALGIDYTIFLVHRARTEAALRGTRDGMVEAVAHTGGVITSAGIVLAAVFAALGVLPLVTLGQLGLIVGVGVIVDTLVVRTVIVPALFALVGDRIWWPGRPASRRVADAG
>CP027434.1|AVL98495.1|3311470_3312031_-|deaminase
MRPLRYAINVTLDGCCHHEAGLPPDEESMRFWTAELQRADALLYGRVTYDMMRAAWRRPESGVWPDWMEEWETPFAEVIDGMPKHVVSATLDAVDWNAELVRGDLSERVRGLKDQPGEGLSVGGVALPAALADLGLIDEYLFVVHPVVAGHGPRLLDGVHERLRLELVERREFRSGAVAQRYRPVA
>CP027434.1|AVL98496.1|3312027_3312642_-|hypothetical-protein
MTNAQTAVEVVDWRRRVFALYEAVRRADSPEEAHELWRIERDELVLRHPATPLLPEDRALFEGLPIASYDPAWRFELPILDTDPATFEFATGTDGIVPFERVGVVEIPDVGSLDVWRLASYGGGLFVPVRDASAGQSGGTYGGGRYLIDTIKGADLGADPRRGTLLLDFNFAYNPSCAYDPAWACPLAPPGNVLTVPIPVGELR
>CP027434.1|AVL98497.1|3312682_3313492_-|hypothetical-protein
MTTPPPPRRTLLVGFGKLGTRLAPLLLADGGEVLALRRTDGPVPDGVTALAADLTVPLTAPLPEVDAVVVTLPPGPDVSSYRTALSHLAAALPAPPTRTVFVSSTGVFDGAGSAEPVTERVEPAPTTDRGRGLRDGEKAAVELFDAVVVRPAGIYGPGREFLLRKVREGAPVTHRRRTNRIHETDLVRILDLLLRMPEPPALVHAVDQAPAPLGDVVTFLADRLGLPVPPDDGGAPSGFVYDGSLVRAVLGRLDYPTYENGYVDMIDRD
>CP027434.1|AVL98884.1|3313563_3314568_+|FUSC-family-protein
MWTGVLRVGPHRGDHRVALRAAVSVAVPLLVLWAAGRLDLSIYASFGAFAALYGRHDVFRDRIRMQASAGGVLLGAMLIGTALSVLAAPAVLSIVVVALVAAAVTLLAYVLQWHPPGPLFTVFATGACATIPATGASFGAVLLVGGASVLFGLALTALVAVVTRTTAEAAPKARPSVGPVAAEMAASVAGAIVGAGVVGLLLGGTHWYWAAVGAVAAVSGAQLNARVIRGIQRLVGTLLGVLVAAGILALDMPPLAVIAVVVVLQGTAELFIGRNYGIAMVFVTPLALLMVHLAAPTPVADLLTDRVLETIIGVVVGTVVAVTSAALRRRNRRR
>CP027434.1|AVL98498.1|3314624_3315278_-|porin
MIGTPRKALAEAVATFLFVLAIIAAVNSGSPLTPLAIGFTLMVLVYSTGHISGAHLNPAVSLGVFLRGGLSVADFVSYLVAQFAGGALAALVALAVWPAGEKAMVIEVGPAFLVEALFTLILVWVVLNSATSKDTAGNSFYGLAIGATVFVGAATVGSISGGGFNPAVALGLSVSGHFAWGSLWLYIVAPAVGAVIAALLFRVLNADDARKIAADAE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP027434_2	2.1\|656098\|29\|CP027434\|CRISPRCasFinder	656098-656126	29	NZ_CP029830	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed1, complete sequence	625330-625358	5	0.828
CP027434_2	2.1\|656098\|29\|CP027434\|CRISPRCasFinder	656098-656126	29	NZ_CP013104	Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence	1395255-1395283	5	0.828
CP027434_2	2.1\|656098\|29\|CP027434\|CRISPRCasFinder	656098-656126	29	NZ_CP043499	Rhizobium grahamii strain BG7 plasmid unnamed, complete sequence	320017-320045	6	0.793
CP027434_2	2.1\|656098\|29\|CP027434\|CRISPRCasFinder	656098-656126	29	NC_008010	Deinococcus geothermalis DSM 11300 plasmid pDGEO01, complete sequence	543652-543680	8	0.724

1. spacer 2.1|656098|29|CP027434|CRISPRCasFinder matches to NZ_CP029830 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.828

gaggtcggcgacccagagaaggtcggcga	CRISPR spacer
tatttcggcgacccggagaagggcggcga	Protospacer
 *  **********.******* ******

2. spacer 2.1|656098|29|CP027434|CRISPRCasFinder matches to NZ_CP013104 (Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence) position: , mismatch: 5, identity: 0.828

gaggtcggcgacccagagaaggtcggcga	CRISPR spacer
caggtcggcgacgcagagacggtcgtcta	Protospacer
 *********** ****** ***** * *

3. spacer 2.1|656098|29|CP027434|CRISPRCasFinder matches to NZ_CP043499 (Rhizobium grahamii strain BG7 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.793

gaggtcggcgacccagagaaggtcggcga	CRISPR spacer
aatgccggcgacccagagaacggcggcgt	Protospacer
.* *.*************** * *****

4. spacer 2.1|656098|29|CP027434|CRISPRCasFinder matches to NC_008010 (Deinococcus geothermalis DSM 11300 plasmid pDGEO01, complete sequence) position: , mismatch: 8, identity: 0.724

gaggtcggcgacccagagaaggtcggcga	CRISPR spacer
cgttccggcggccaagagaaggtcggcgt	Protospacer
 .  .*****.** **************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1522473 : 1530914

Mycobacterium_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVL96901.1\|1522473_1523826_+	hypothetical protein	A0A2H4PED4	Mycobacterium_phage	3.0e-21	41.1
AVL96902.1\|1523822_1524020_+	hypothetical protein	NA	NA	NA	NA
AVL96903.1\|1524016_1524559_+	hypothetical protein	F1B2N6	Tsukamurella_phage	2.1e-10	30.7
AVL96904.1\|1524571_1525201_+	hypothetical protein	NA	NA	NA	NA
AVL96905.1\|1525203_1525587_+	hypothetical protein	NA	NA	NA	NA
AVL96906.1\|1525651_1526107_+	hypothetical protein	NA	NA	NA	NA
AVL96907.1\|1526103_1527102_+	hypothetical protein	A0A0A7RWN0	Mycobacterium_phage	1.3e-29	37.5
AVL96908.1\|1527124_1527868_+	hypothetical protein	A0A1J0MDL4	Mycobacterium_phage	1.1e-12	37.9
AVL98763.1\|1528056_1528464_+	hypothetical protein	A0A0U4B2J9	Arthrobacter_phage	1.7e-20	51.5
AVL96909.1\|1528460_1530914_+	DNA primase	A0A222ZSY8	Mycobacterium_phage	3.4e-108	43.7

DBSCAN-SWA_2

1540845 : 1551209

Rathayibacter_phage(42.86%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVL96923.1\|1540845_1542354_+	hypothetical protein	A0A1P8VV94	Rathayibacter_phage	2.4e-128	58.1
AVL96924.1\|1542350_1543700_+	peptidase	A0A1P8VV81	Rathayibacter_phage	7.1e-84	45.4
AVL96925.1\|1543701_1544070_+	DUF2190 domain-containing protein	A0A160DCL2	Gordonia_phage	1.0e-16	50.0
AVL96926.1\|1544080_1544998_+	hypothetical protein	A0A1P8VV78	Rathayibacter_phage	3.5e-58	43.8
AVL96927.1\|1544997_1545417_+	hypothetical protein	NA	NA	NA	NA
AVL96928.1\|1545430_1545799_+	hypothetical protein	A6N202	Microbacterium_phage	1.6e-17	45.3
AVL96929.1\|1545795_1546125_+	hypothetical protein	NA	NA	NA	NA
AVL96930.1\|1546136_1546457_+	hypothetical protein	A0A142K9H4	Gordonia_phage	8.5e-12	39.0
AVL96931.1\|1546389_1546869_+	hypothetical protein	NA	NA	NA	NA
AVL96932.1\|1546865_1547624_+	hypothetical protein	NA	NA	NA	NA
AVL96933.1\|1547627_1548029_+	hypothetical protein	NA	NA	NA	NA
AVL96934.1\|1548341_1551209_+	hypothetical protein	A0A1B3B020	Gordonia_phage	8.3e-66	42.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP027434

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection