CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Target MGE spacer number	Prophage number
CP027252	Acinetobacter pittii strain WCHAP100020 plasmid p2_100020, complete sequence	0 crisprs	NA	0	0
CP027251	Acinetobacter pittii strain WCHAP100020 plasmid p1_100020, complete sequence	0 crisprs	WYL	0	1
CP027253	Acinetobacter pittii strain WCHAP100020 plasmid pOXA58_100020, complete sequence	0 crisprs	NA	0	0
CP027254	Acinetobacter pittii strain WCHAP100020 chromosome, complete genome	3 crisprs	csa3,cas3,DEDDh,WYL	2	7

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

61797 : 68869

Acinetobacter_phage(44.44%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVN20361.1\|61797_62730_+\|transposase	IS5/IS1182 family transposase	A0A1V0E8E1	Vibrio_phage	3.9e-57	41.0
AVN20360.1\|62860_63058_-	hypothetical protein	A0A1B1P9F8	Acinetobacter_phage	7.5e-11	57.1
AVN20359.1\|63150_63369_-	hypothetical protein	A0A0R6PIC9	Moraxella_phage	4.0e-21	77.4
AVN20358.1\|63425_64028_-	hypothetical protein	A0A0P0J0J1	Acinetobacter_phage	3.2e-36	62.2
AVN20357.1\|64234_64504_+	transcriptional regulator	NA	NA	NA	NA
AVN20356.1\|64558_64888_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A088CBP5	Shigella_phage	2.9e-23	64.6
AVN20355.1\|64874_65162_+	transcriptional regulator	A0A088CD40	Shigella_phage	3.3e-15	48.4
AVN20354.1\|65198_65387_-	hypothetical protein	NA	NA	NA	NA
AVN20353.1\|66112_66574_-	hypothetical protein	A0A0P0IRI6	Acinetobacter_phage	2.0e-54	73.8
AVN20352.1\|66634_67090_-	hypothetical protein	A0A0P0HSF5	Acinetobacter_phage	4.7e-80	95.4
AVN20351.1\|67750_67987_-	hypothetical protein	NA	NA	NA	NA
AVN20350.1\|68398_68869_-	hypothetical protein	A0A2H4JDI9	uncultured_Caudovirales_phage	2.4e-55	65.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. CP027254

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CRISPR-Cas detection and classification

Crispr_ID: CP027254_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027254_1

99324-99459

Orphan

Consensus_repeat	Method
AAAGAAACAATAAAGTTTCATACTG	PILER-CR

2 spacers

TnsE_C

The CRISPR arrays of CP027254_1

>merge|CP027254|1|99324-99459|PILER-CR
AATGAGACAATATAGTTTCATACTGGATTTTTCGTAAGTTATTGATATTTATTTCATCATAAAACAATAAAGTTTCATACTACTTTTTGGTTTAGAGTATCCAAGATGGAAAAAGAAACAATAAAGTTTCATACTG

>CP027254|1|1|99324-99459|PILER-CR
AATGAGACAATATAGTTTCATACTG	GATTTTTCGTAAGTTATTGATATTTATTTCATCATA
AAACAATAAAGTTTCATACTACTTT	TTGGTTTAGAGTATCCAAGATGGAAAAAG
AAACAATAAAGTTTCATACTG

Protein	Signature genes	Signature genes Name	Protein_function
CP027254.2\|AVN20475.1\|92130_94095_-\|carbamoyltransferase	unknown	unknown	gnl\|CDD\|225103
CP027254.2\|AVN20482.1\|105052_105640_-\|DUF3780-domain-containing-protein	unknown	unknown	gnl\|CDD\|315331
CP027254.2\|AVN20478.1\|96490_97516_+\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
CP027254.2\|AVN20485.1\|110029_110641_-\|hypothetical-protein	unknown	unknown	unknown
CP027254.2\|AVN20474.1\|91648_92134_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
CP027254.2\|AVN20476.1\|94739_95765_-\|IS30-family-transposase	unknown	unknown	gnl\|CDD\|225382
CP027254.2\|AVN20487.1\|112426_113944_-\|transposase	unknown	unknown	gnl\|CDD\|377670
CP027254.2\|AVN20480.1\|99485_102203_-\|DEAD/DEAH-box-helicase	unknown	unknown	gnl\|CDD\|350769
CP027254.2\|AVN20479.1\|98802_99087_+\|hypothetical-protein	unknown	unknown	unknown
CP027254.2\|AVN20472.1\|88070_89276_+\|imidazolonepropionase	unknown	unknown	gnl\|CDD\|236478
CP027254.2\|AVN20484.1\|108910_109993_-\|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl\|CDD\|225412
CP027254.2\|AVN20481.1\|102206_105053_-\|DUF1156-domain-containing-protein	unknown	unknown	gnl\|CDD\|224657
CP027254.2\|AVN20483.1\|105636_108705_-\|DUF499-domain-containing-protein	unknown	unknown	gnl\|CDD\|224400
CP027254.2\|AVN20477.1\|95891_96119_-\|hypothetical-protein	unknown	unknown	unknown
CP027254.2\|AVN20470.1\|85003_86542_+\|histidine-ammonia-lyase	unknown	unknown	gnl\|CDD\|236484
CP027254.2\|AVN20471.1\|86606_88019_+\|amino-acid-permease	unknown	unknown	gnl\|CDD\|182566
CP027254.2\|AVN20489.1\|115639_117781_-\|transposase	unknown	unknown	gnl\|CDD\|378147
CP027254.2\|AVN20488.1\|113944_115612_-\|transcriptional-antiterminator	unknown	unknown	gnl\|CDD\|379165
CP027254.2\|AVN20486.1\|110858_112427_-\|hypothetical-protein	TnsE_C	TnsE	gnl\|CDD\|376049
CP027254.2\|AVN20473.1\|89286_90207_+\|formimidoylglutamase	unknown	unknown	gnl\|CDD\|237500

Protein	Function_ID	Function_description	E-value
CP027254.2\|AVN20475.1\|92130_94095_-\|carbamoyltransferase	gnl\|CDD\|225103	COG2192, COG2192, Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones].	5.82101e-84
CP027254.2\|AVN20482.1\|105052_105640_-\|DUF3780-domain-containing-protein	gnl\|CDD\|315331	pfam12635, DUF3780, Protein of unknown function (DUF3780). This family of proteins is functionally uncharacterized.This family of proteins is found in bacteria. Proteins in this family are typically between 189 and 206 amino acids in length. There are two conserved sequence motifs: PEERWWL and GWR. This family is found in a very sporadic set of bacterial species, suggesting that it may have been horizontally transferred. One protein is annotated as plasmid borne.	1.82629e-89
CP027254.2\|AVN20478.1\|96490_97516_+\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	1.97342e-93
CP027254.2\|AVN20488.1\|113944_115612_-\|transcriptional-antiterminator	gnl\|CDD\|379165	pfam13401, AAA_22, AAA domain.	1.06745e-20
CP027254.2\|AVN20474.1\|91648_92134_-\|N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.78712e-13
CP027254.2\|AVN20476.1\|94739_95765_-\|IS30-family-transposase	gnl\|CDD\|225382	COG2826, Tra8, Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair].	1.97342e-93
CP027254.2\|AVN20487.1\|112426_113944_-\|transposase	gnl\|CDD\|377670	pfam06527, TniQ, TniQ. This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons.	1.4172e-17
CP027254.2\|AVN20480.1\|99485_102203_-\|DEAD/DEAH-box-helicase	gnl\|CDD\|350769	cd18011, DEXDc_RapA, DEXH-box helicase domain of RapA. In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	4.12539e-47
CP027254.2\|AVN20472.1\|88070_89276_+\|imidazolonepropionase	gnl\|CDD\|236478	PRK09356, PRK09356, imidazolonepropionase; Validated.	0
CP027254.2\|AVN20484.1\|108910_109993_-\|ImmA/IrrE-family-metallo-endopeptidase	gnl\|CDD\|225412	COG2856, COG2856, Predicted Zn peptidase [Amino acid transport and metabolism].	7.97047e-15
CP027254.2\|AVN20481.1\|102206_105053_-\|DUF1156-domain-containing-protein	gnl\|CDD\|224657	COG1743, COG1743, Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair].	1.39698e-33
CP027254.2\|AVN20483.1\|105636_108705_-\|DUF499-domain-containing-protein	gnl\|CDD\|224400	COG1483, COG1483, Predicted ATPase (AAA+ superfamily) [General function prediction only].	2.32191e-24
CP027254.2\|AVN20489.1\|115639_117781_-\|transposase	gnl\|CDD\|378147	pfam09299, Mu-transpos_C, Mu transposase, C-terminal. Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology.	1.36779e-06
CP027254.2\|AVN20470.1\|85003_86542_+\|histidine-ammonia-lyase	gnl\|CDD\|236484	PRK09367, PRK09367, histidine ammonia-lyase; Provisional.	0
CP027254.2\|AVN20471.1\|86606_88019_+\|amino-acid-permease	gnl\|CDD\|182566	PRK10580, proY, putative proline-specific permease; Provisional.	0
CP027254.2\|AVN20486.1\|110858_112427_-\|hypothetical-protein	gnl\|CDD\|376049	pfam18623, TnsE_C, TnsE C-terminal domain. The bacterial transposon Tn7 facilitates horizontal transfer by directing transposition into actively replicating DNA with the element-encoded protein TnsE. Structural analysis of the C-terminal domain of TnsE identified a central V-shaped loop that toggles between two distinct conformations. It is suggested that a conformational change within the C-terminal domain of TnsE underlies target site selection by regulating stable engagement of the target DNA while providing a signal for activating transposition.	3.88692e-42
CP027254.2\|AVN20473.1\|89286_90207_+\|formimidoylglutamase	gnl\|CDD\|237500	PRK13776, PRK13776, formimidoylglutamase; Provisional.	2.524e-129

>CP027254.2|AVN20479.1|98802_99087_+|hypothetical-protein
MKLHKFILFLNLVVGAYSITNDDANAQQEFKRICLSDEHMQASCNCVCQQLAQLYSPQIVQRLKHTSLQSPVLPQGFAPNLFSSIQRCDKNEMG
>CP027254.2|AVN20478.1|96490_97516_+|IS30-family-transposase
MEYIKLSYHHLNFEDRTALMLESRKEGFSARKFAELIKRHPSTIYRELKRNSINDVYQARYASDNTFARRRRGHRKLKIDSILWKFIVEAIRCLWSPQQIAKRLKTFPDLDQTMNVSHTTIYSTIRALPKGELKKDLLSCLRHENKKRKANGEPKKDSILQDIKTIHERPAEVQERKIPGHWEADLIKGKDNKSSIATLIERNTRLCILATLPDAKAESVRKALTEALKYLPAELRKTLTYDRGREMAEHKILEEDLGIDVYFCDPHSPWQKGTCENMNGLIRQYLPKGIDLNQADQHYLNQVAMSLNTRPRKALDWLTPLEKFAQLVDYHKTFQTVAPHV
>CP027254.2|AVN20477.1|95891_96119_-|hypothetical-protein
MIIMLKHNYNINDSSKLILYPMLSDPIELNLKPGDYIIFWAKTTVHARTTLKEGEEVCIMSYGFPLKNLEILNGN
>CP027254.2|AVN20476.1|94739_95765_-|IS30-family-transposase
MEYIKLSYHHLNFEDRTALMLESRKEGFSARKFAELIKRHPSTIYRELKRNSINDVYQARYASDNTFARRRRGHRKLKIDSILWKFIVEAIRCLWSPQQIAKRLKTFPDLDQTMNVSHTTIYSTIRALPKGELKKDLLSCLRHENKKRKANGEPKKDSILQDIKTIHERPAEVQERKIPGHWEADLIKGKDNKSSIATLIERNTRLCILATLPDAKAESVRKALTEALKYLPAELRKTLTYDRGREMAEHKILEEDLGIDVYFCDPHSPWQKGTCENMNGLIRQYLPKGIDLNQADQHYLNQVAMSLNTRPRKALDWLTPLEKFAQLVDYHKTFQTVAPHV
>CP027254.2|AVN20475.1|92130_94095_-|carbamoyltransferase
MRLSLGIHLGHHASLALVQDGTLIAATRLERITRIKNFVCHGLSKRLEIKNFLESFGFSIEQVDIIVSSFQGTARGGVGFQHSVIEEDFDDFDPYSNNHYVISHHLAHAYCASSYAPKKEICVLVSDYAGSATEELKDYEMKFSEWYNSTIKCKKPVKLKSENLSIYKIKLGEYFDLKYRESQIPHPNNFSIIQSVGALYENVSRLIFNKEGQHGSLMALAAYNKRKELIKIFEEEDGEIIYHNNWQQMLYKLPSNNNDQFTLTDETKFYLADSCQNAAENILLHYAKKASELTGLKDIALAGGSFLNILANSKIYNSSFFDSVSLPSAPNDAGISIGCAFWGAVKLKDQVNKVTTDRLGIKYELDIDILNKEHKNFISFKKTNTHEVAKLIFDGKIFARCSGRSEFGPRALGGRSILASPLLDSTKNKLNKIKKRQSWRPVAPIILKEEIGNIFHGPLNSSWMTFSYNISDSNLRKMPALEHPDNTTRCQTLDYEDDPWLYDLITKFKEITGFGVLVNTSFNGPDEPIIENYNQAIDWYLKKFDVDYLLIDNYLVERNNYFTEAIRDNKYRINNNIFILKKFNDGSLNLNDDLILSLNDISLIIKEEPLKRLFLFNQPLNFNDKLFDDKNSNLHFELYNLFIYKFFLINEVLS
>CP027254.2|AVN20474.1|91648_92134_-|N-acetyltransferase
MNSLNVFLLSISDAENTFNYLQDDELYLYIPDVKYENIQQLRNRYQSLIDGSHNPNEEWMNWIIYSDFHKNYPIGTIQATVLKNEKKAYVGYVIYKKYWNQGYGYSALQWLENFLKEKDNVQYLEGYVDPRNIFSIKILEKSGFIKTHEEDNDYVYRKQIK
>CP027254.2|AVN20473.1|89286_90207_+|formimidoylglutamase
MNHTFKWQGRHDGEGEAHQRIHHIMNKNQHAEFALIGFSSDEGVKRNKGRVGAADAPDAIRNQLANLPIHRPVSIVDLGTVTCEYDNLEQAQTELAEQVANSLQNGLKPIVLGGGHEVAFGSFSGLFQYVQAHAPDKKIGIINFDAHFDLREAEHATSGTPFLQAARLSEQHQKQFNYLCIGVANHANTKVLFDTADALNCSYLRDHEVNIFNLNNVLAAVDAFIEKVDCLYITIDLDVFAAAVAPGVSAPAVKGIDLATFEAIFKHIQETGKIKLLDIAECNPKFDLDNRTAKLAAYIVYQYFFN
>CP027254.2|AVN20472.1|88070_89276_+|imidazolonepropionase
MKKLWQNCHIATMQNGQYSYIEDAAIVTEGHLIHWIGKQQQLPADTYSETVNLNGAWVTPGFIDCHTHSVFGGNRSVEFEKRLQGVSYAEIAASGGGIASTVRATREASEEQLLSSALKRIRCMQQDGVTTIEIKSGYGLNYENERKMLRVIRQIGEALPMTVKSTCLAAHALPPEYKDQSDAYIEHICTEMLPKLHAEGLVDAVDAFCEHLAFSPAQVERVFKTAQSLGLPVKLHAEQLSSLGGSSLAARYHALSADHLEYMTEDDVKAMAESGTVAVLLPGAFYLLRETQYPPIESLIKHGVRIALSSDLNPGTSPALSLRLMLNMGSTLFRLTPEQALAGVTIHAAQALGLEQTHGSLEQGKVADFVAWDIEHPSEIVYWLGGDLPKRVVQYGQEVIF
>CP027254.2|AVN20471.1|86606_88019_+|amino-acid-permease
MSQSSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYIVAGIAIYIVMRALGEMAVQNPVSGSFSHYASQYIGPLAGFTTGWTYVFEMIIVALADVTAFGIYMGFWYPDVPRWIWILSLIMFLGAINLIHVKVFGELEFWLSIVKVSAIVAMILGGIGLMFYGFHADHSSVVPGIQNLWIYDGFMPHGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINAVPVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIQSAATILNIVVITAAVSAINSDVFGAGRMLYGMANRGQAPRVFQKLSRNGVPWMTVVVMAGVLLIGVVLNYLIPENVFMIIASIATFATVWVWLMILLSQVAMRRKLSTAEIKALDFPVIGWPYAPAFAIGFMVFILVMMGYFPDSRPAIYVGITWLVLLMIAYRIWVKPQQNSGKQNNSIPQNIEIES
>CP027254.2|AVN20470.1|85003_86542_+|histidine-ammonia-lyase
MELLIQPGKLTLADLRQAYLNPIKVKLDESASSAINASVACVEKIVNEGRTAYGINTGFGLLASTKIAPEDLEKLQRSLVLSHAAGVGEALDDAMVRLIILLKANSLARGFSGIRRKVIDALLALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGEGKARYKGEWLPAVEALKVAGLEPISLAAKEGLALLNGTQVSTAYALRGLFEAEDLFAAATVCGGLSVEAMLGSRAPFDARIHEVRGQRGQIDVAAAYRDLLTDSSEIAHSHEDCSKVQDPYSLRCQPQVMGACLTQIRQAAEVLEIEANAVSDNPLVFAEQGDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISMMMDRHMSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAHPASVDSLPTSANQEDHVSMAPNAGKRLWYMADNVRGILAVEWLGACQGLDFREGLKSSPKLEQARKILRAQVPYYSEDRFFAPDIEQASELLSSGCLNELIIPKLLPSLSEV
>CP027254.2|AVN20480.1|99485_102203_-|DEAD/DEAH-box-helicase
MAIQRFSSRTEKLDTEFLAKSLKGAIKYFRIAGYFRSSIFELVGEEIAKIPEVKIICNSELDLADFQVATGRNTALKERWNEVDVEAEALLKKERYQILDRLLQSGNVEIRVVPRDRLFLHGKAGSIHYNNGCRKSFIGSVNESKSAFAHNYELVWQDDDEESADWVEKEFWALWNDGVPLPEAILAEITRVAHRKEITIEVLKPDEVPAAAMAEAPIYRGGEQLQPWQRSFVTMFLEHREVYGKARLLLADEVGVGKTLSMATSALVSALLDDGPVLILAPSTLTIQWQIEMMDKLGVPAAVWSSQKKVWLSVEGQILSPRGDASSIKKCPYRIAIVSTGLIMHQREKADFVKEAGMLLKNRFGTVILDEAHKARVRGGLGDQAIEPNNLMAFMQQIGRRTRHLILGTATPIQTNVRELWDLIGILNSGAEFVLGDALSPWHDHEQAIPLITGKAQITSEAEVWHWLSNPLPPGKEHHIVQQIRDYLSIDNKSFGCSHRFEDLDYMIQSLWLSECMSADFFKENNPILRHTVLRKRKQLEDDGLLERVGVYTHPIARNLAQYQARFVGLGIPTNTPFQVAYEKAEEFSKLLQSRTRSAGFMKSLMLQRICSSFASGLKTAQKMLKHTVSDEDEDLIADVEHVLSEMTPAEVACLKAIETQLSRPEAVDSKLNTVKWFLTDFRTDGKTWMEHGCIIFSQYYDTAEWIAKELAKSFKGEVVAVYAGVGKSGLFKGEQFNNVEREVIKSAVKTREIRLVVATDAACEGLNLQTLGTLINIDLPWNPSRLEQRLGRIKRFGQTRKFVDMLNLVYSETQDEKVYNVLSERLRDTYDIFGSLPDTIDDEWIDNEEELNSRMNEYMHERKKAQDAFSVKYRGTLDPDAHLWERCATVLSRRDIVNKLSEPW
>CP027254.2|AVN20481.1|102206_105053_-|DUF1156-domain-containing-protein
MALQPLEWKDKPSLIEHLFPVQKISAESFKEQSAVQSKTLVALGSYWKGRKPLVLNKACILGALLPATENHLKDLEIFELLMGMTPEAMQKRIEENLPLSKRDDIGDYLTLPFNDQVRAGKRAEEIGDSLFSLIWNKVNTHLGTSANSIPELVEQMGIARFGHRPNVADVFSGSGQIPFEAARLGCNVYASDLNPMACLLTWGSFNIVGAPAENISNLTIAQTKLVERVQQEIDELGIETDGKGWRAKAYLYCVEVICPESGWAVPLLPTLIVSASKFVVVNLVPIESEKRYMIEVKYCKNKNEMEMQDKPTVSGGYLIHSPSPDQEYRSKISSIRGDIRVGRNTTSALRKWEKEDFTPRKDDIFQERLYCVQWEKVAKEKSRLETEFRSVTQADLEREAKVISYVENHFKEWQEKGYIPDMVIEKGYNTDQPIRERGWTYWHHLFAPRQLLMLGIIKKTLLTDPEFSEQLYVSFSRLLDWSTKLCRYGTGAARESIAQTFYNQALNTFYNYGVRPFSFATKYLLEKTYNFPLPSETFVNCHPAQDIEVENDIYVTDPPYGDAVKYEEITEFFIAWLRKNPPEKFSQWTWDSRRSLAIKGEDDGFRTGMIAVYRKMAQKMPDNGLQILMFTHQSGAIWADMANIIWASGLQVTAAWYVVTETDSALRGGSNVKGTIILILRKRHQNLETFRDDLGWEIEEAVKEQVESLIGLDKKVRAQGTEGLYTDADLQMAGYAAALKVLTAYSRIDGKDMVTEAEAPRKKGKKTFVDELIDFAVQTAVQFLVPVGFEKGEWQKLQAVERFYLKMLEIEHQGSKTLDNYQNFAKAFKVHHFDQLMSDVSKANSARLKLSSEFRSAMMSGDAEMAGTPLRALLYALFELSKEVEIDDVLLHLMENCPNYLPNKQLLAKMADYLAEKREGLKSTKTFNPELEASCARILAEAIRNQRL
>CP027254.2|AVN20482.1|105052_105640_-|DUF3780-domain-containing-protein
MNKTIDFGASPEFGMHHFYVEIPAAPHDAVTIYEDYGFDGDESRRETIECRLILARELWTKIRDDVRRDFNARLKVKNQSTGTWSTGKIKLDRFLGRELCVLGWAAEHASPDECLVICQKWLALRPEERWWLYSKTAAEAGRNDQTYHGWRKALYCALSDGSNIKLGIKIKPKSKKLQTEEKVQDLFGFIEKGEI
>CP027254.2|AVN20483.1|105636_108705_-|DUF499-domain-containing-protein
MKTVHQVCQLQPKALEINVGDQIEQLDQIIHDTDGSEYFKKTFITDGFRNLLSKGIARLAGKSNDAIFHLKQAMGGGKTHLMVGFGLLAKDAQLRDEILSSTLYQSDFISAKIAAFNGRNNPHTYFWGEIARQLGKEKDFKEYWESGAKAPDEQAWINLFEGDEPILILLDEIPPYFHYYSTQVLGQGTIADVVTRAFSNMLTAAQKKKNVCVVVSDLEAAYDTGGKLIQRALDDATQELGRAEVSITPVNLESNEIYEILRKRLFSSLPNKNEISEIASIYAARLSEAARAKTVERSAEALASDIESTYPFHPSFKSIVALFKENEKFKQTRGLMELVSRLLKSVWESNEDIYLIGAQHFDLSIHEVREKLAEISEMRDVIARDLWDSTDSAHAQIIDLNNGNQYAKQVGSLLLTASLSTAINSVKGLTESEMLECLIAPNHQASDYRNAFVELTKSAWYLHQTQEGRNYFSHQENLTKKLQGYADKAPQNKVDELIRHRLEEMYRPITKEAYEKVLPLPEMDDADATLKNSRALLIISPDGKTPPGVVANFFRSLVNKNNILVLTGDKSSIASIEKAARHVYAVAKADNEIAGSHPQRKELDEKKAQYEQDFQTTVLSVFDKLLFPGNNRGEDVLRPKALDNTYPSNEAYNGERQVVKTLTSDPIKLYTQITENFDALRARAESLLFGTLDEVRKTDLLDKMKQKTQMPWIPNRGFDQLAIEAYQRGVWEDLGNGYITKKPKPKTTEVIISEDSSPDDAGTVRLRIDVANAGNSPRIYYAEDGDVSQSSPVLSDNTLATKALKVQFLAVDPTGKNLTGDPTTWKNHLTLRNRFDEISRTVELFVAPRGSIKYTLDGSEARNGETYTVPIQLSDEETTVYVFAECEGLEEKRNFTFAASGSKEIPIIKDKPAILVSSSPKRMDSSAKTYEGLNIAKDKGIKFEQVSLMVGSAPKVIHMSLGEMKISAEFIETALAHLQTLLSPEAPVVMTFKKAYTQTGHDLEQFTKQLGIEIGSGEVEQQ
>CP027254.2|AVN20484.1|108910_109993_-|ImmA/IrrE-family-metallo-endopeptidase
MNTYFNGLELRLLRQLNHLSLEDLSTHVGKSRQFLHKIEMNQVAPTSDLIGVLSNFFNVKTEIFFSSHPILQEEQINFRSNKTAKVFTKQSVIAQGEYLKRLVEFIEANLRLPRYSIPSVDHVQNFQDIENAALQFRKHFNLGLGPISDMTKLCEMLGIFVTTFPSVSNEVDALSIASKRPIFVNNEDSSTCRQRFNLAHELGHLVLHDGCVTGDSLTESQAHRFASALLIPQEMMNSHFRYCFNGRFNWNKLSKMKMDWKISKAALLYRAKSLGLIDDVSYRSGYIHLKRTGEALLETEDKDIPREIPHLLENCFKALNKKRISAESIANELNISLDLLNKITQLNHQKPNTSKLQLVI
>CP027254.2|AVN20485.1|110029_110641_-|hypothetical-protein
MDLSKNPPPNYYDSSLNNEILSYFANHMLEVHSQTLRDLNSQDDDNYTISCTIFGRCRNRFSRVIRNGNAPVSTSLEDSSNKFTFKIGNTSGIRFFKESDYLRPKRPNFFKQSHNFELFEIDDNLPVFWRFILVPARTDEEETFIAFVGFNQKLQPITAWTSNNTSRFIFDPEAILPEPADLKSYNIDDLLADDDLDNTSEIE
>CP027254.2|AVN20486.1|110858_112427_-|hypothetical-protein
MKIKNFPENAKITFLGEIFKFNHLKSWNIKLGIHVDSELSVKHSRLSNLPAFARGRCLNPSDGQCSKGGYKININIQSNEDWKVKVDSKNRGYYFEFDFNRGSEQNPDLLHIRIPQIELARVLFFHNAYLARNCIDQGILAREFFVDPIDQTTTVIHVLPHRTFPLGQFSNEGIRRLLSWILLDENARQSYESIAHYFKLEAKQFEEKTSWQFHFIPPQLVNISLKMIGRFDPTTNEYIVFEITDLHNIQTSLPPIVLYESPEFKSGNSTGSGGGSSGSNQGGNDSSVDDDIEGDSNSKLVEIEIPQTSLSFSNPIETRKVVKKKTKSGSCGYDDVTEYEEVGVGTGEPTVNGDGAQGEFNGLKDDSDVIALYMQRFDAFKLLVKQLALKHHLKYEEKLHYLQKVGRSRLHRTLDGNNRCLLEVRFFIENHWYAILEIDTSDNAKPLSTLIVQIYDLNKWNHNFKDIAKKIVKNSLRWPSVESLQDFGTPYTLNHPKHLVELTESDDEFNGWLQRMEKLLNL
>CP027254.2|AVN20487.1|112426_113944_-|transposase
MLNFPLPYQNELIYSTVARAGIRLALSSPKQLLDEIFQNRKVIATVDLPCHLNAIINQYPSNQLSLEDIAYQHTLFPIYAPFVPEDRRQQCLQWMAEVSQGSIHLALGVNASRLKPIHKLRYCPACFKEQLELYSELYWSRLWQIQGACCPIHGELIDSIIELRSLHRHDFITPTYQTCPEQIQSKATSDSLFITKKLLELLSLPSSESPHYEQWTRFYHQLAQKNHCIRGRNYISHDKILDKIIARWSSKFLRQYNLGDLKSETGWLRSIFRKHRKSFSYLEHIVVIEALSNKEWTFSAILEQVKNLNEDSKDNNSQNLNICVHPNHFEYREKWLKLVKELGIKPARSIDQALYAWLYRNDKDWLLKINQTFHQGFIPQGAKVDWYNRDLTYVRQLIQLYNELIWDVDSPRRSAKWWLSQITHVSTIEKNLYRLPITQSFLKRYSEDISSYQIRRLTQVFIEIKMQSQDLPRWRILRKAGLSDERMTSETAKFLNMALQYLRLN
>CP027254.2|AVN20488.1|113944_115612_-|transcriptional-antiterminator
MSNKVIVKEYQPSIGHYAGNPFIEALPPILDTPDIIKALRGKVNFDITDQSLPASQRIHLIPQLLNSFFHPIERHIELWTKFSIMLRQGYVGRNISNGELNKHIQNGYERTMKGDISAFRYEPARSTAQSMSIIGCSGIGKTTTINNILSVYPQVIYHEKYNFTQIVYLKIDCPHDGSLKSLCLHFFRAVDIALDTNYEAKYALKRHGVETLLNLMRQIANFHAIGLLIIDEIQHLNIKNSGGADKMLNFFVTLVNVISLPVIMVGTPKARYIFNDLRGNRRAAGFGSVLWEPIKNEPNLELNNRIYKSEWNAFTDALWKYQWLNKADMHLSDEIRECLYDLSQGILDIAVKLFVLAQISAITSGLERITIKLLKKTYHDELKPIHPMVNALRSKDPEKIIQFSDLIIPEVDQQILKLQMIVDKHTESTEYDDLSEYNGNKEAIRLHHLLLGLDFKSELLVPTIKRAFQQHPHLSMQELMPIVMIWLNDIGKNIQTNPKPKNKSKRVKQDQWHTLDTEDLRFQFSQKDEKQNFYQHLKEHTQLIFNMERWFEQVS
>CP027254.2|AVN20489.1|115639_117781_-|transposase
MLRINDVYQYQDLSIRILKILSEHIVWIDINDVKALPEIISKTELFHAIESFEVFRIEDPFQEIALIQPEKGSTSQLKRDENYNLIKAIVDNEQFYIPSIRSSLINEIINNKKSTKQTIYRLLRQYWQRGQTPNALIPNYQNSGAKGSKKVASQKLGRKRTHKEGTGAIITQEIERLFHLTISKYLLSNKKHSLKYANREFQKLYRTLYPDIPENEYPTLRQFQYFYHREYNQVARLQKRSNDIEYSKDLRQLHSTVNTQVLGPGSRYEIDATIADIYLVSNLDRSRIIGRPTIYFVIDVFSRMVTGLYIGLENASYKTSIQALYCAFTDKVALCKKYGIDITYENWPCIGLPDAILADRAELFGHQVENLEKSFSIRLENAPPYRGDLKPIVESRFKLIQAEFKPFAKGVVQDVITKKRGGKDYRLDATLNLDEFTKIILLSVLKYNQFHQINNYDRDIDLPHDLPAVPMALWNWGIQHRTGKLRTASDQAVYVALLPREKVTLSNRGLKLFGVTYTCPELYEKGWLHRQNTINRPKFLYAAYDPSNAEKIYVFYEQSSLKYWEATISDYSREFRGYSFWEVWQINSVQKKTFEKQDIKNNLAQSELEQKIMDIIQQASSETPLSTQSQKSRISEIRSNRSHEKELERSKLKGTTSSVIDTATSVMKPEITQDAQSNVIPMPKRKKSSDELDEDLKLRFPLYHDLLSEDDEP

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Crispr_ID: CP027254_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027254_2

859806-859911

Orphan

Consensus_repeat	Method
TGTAACCATCCATGCAGAAGCAGTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027254_2

>merge|CP027254|2|859806-859911|CRISPRCasFinder
TGTAACCATCCATGCAGAAGCAGTGAATGTTAACGGTAGTGACTGCATGACAAACGGCTTCATCACTGCAGCGATTCCTGGTGTAACCATCCATGCAGAAGCAGTG

>CP027254|2|1|859806-859911|CRISPRCasFinder
TGTAACCATCCATGCAGAAGCAGTG	AATGTTAACGGTAGTGACTGCATGACAAACGGCTTCATCACTGCAGCGATTCCTGG
TGTAACCATCCATGCAGAAGCAGTG

Protein	Signature genes	Signature genes Name	Protein_function
CP027254.2\|AVN21130.1\|846109_847009_+\|neutral-zinc-metallopeptidase	unknown	unknown	gnl\|CDD\|282131
CP027254.2\|AVN21138.1\|874703_875336_-\|chloramphenicol-acetyltransferase-CAT	unknown	unknown	gnl\|CDD\|100040
CP027254.2\|AVN21125.1\|839867_841301_+\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|180579
CP027254.2\|AVR49325.1\|862627_862954_+\|hypothetical-protein	unknown	unknown	unknown
CP027254.2\|AVN21128.1\|843930_844944_-\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|183400
CP027254.2\|AVN21131.1\|847248_848751_+\|sodium:proton-antiporter	unknown	unknown	gnl\|CDD\|223104
CP027254.2\|AVN21122.1\|835632_835767_-\|hypothetical-protein	unknown	unknown	unknown
CP027254.2\|AVN21129.1\|845152_846082_+\|DUF808-domain-containing-protein	unknown	unknown	gnl\|CDD\|377542
CP027254.2\|AVN21139.1\|875447_875840_-\|RidA-family-protein	unknown	unknown	gnl\|CDD\|100005
CP027254.2\|AVN21133.1\|868821_870477_+\|poly-alpha-glucosyltransferase	unknown	unknown	unknown
CP027254.2\|AVN21127.1\|842629_843520_+\|succinate--CoA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|180194
CP027254.2\|AVN21136.1\|873353_874103_+\|hypothetical-protein	unknown	unknown	unknown
CP027254.2\|AVN23733.1\|872998_873328_+\|methyltransferase	unknown	unknown	gnl\|CDD\|226219
CP027254.2\|AVN21134.1\|870473_872204_+\|CapA-family-protein	unknown	unknown	gnl\|CDD\|214858
CP027254.2\|AVN21124.1\|838609_839806_+\|2-oxoglutarate-dehydrogenase-complex-dihydrolipoyllysine-residue-succinyltransferase	unknown	unknown	gnl\|CDD\|235571
CP027254.2\|AVN21137.1\|874144_874582_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
CP027254.2\|AVN23732.2\|863915_868676_+\|type-I-secretion-C-terminal-target-domain-containing-protein	unknown	unknown	gnl\|CDD\|380150
CP027254.2\|AVN21123.1\|835769_838610_+\|2-oxoglutarate-dehydrogenase-E1-component	unknown	unknown	gnl\|CDD\|236499
CP027254.2\|AVN21135.1\|872200_872917_-\|metalloprotease	unknown	unknown	gnl\|CDD\|239806
CP027254.2\|AVN21126.1\|841448_842615_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234813

Protein	Function_ID	Function_description	E-value
CP027254.2\|AVN21130.1\|846109_847009_+\|neutral-zinc-metallopeptidase	gnl\|CDD\|282131	pfam04228, Zn_peptidase, Putative neutral zinc metallopeptidase. Members of this family have a predicted zinc binding motif characteristic of neutral zinc metallopeptidases (Prosite:PDOC00129).	1.82872e-126
CP027254.2\|AVN21138.1\|874703_875336_-\|chloramphenicol-acetyltransferase-CAT	gnl\|CDD\|100040	cd03349, LbH_XAT, Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. Members of this class of enzymes include Enterococcus faecium streptogramin A acetyltransferase and Pseudomonas aeruginosa chloramphenicol acetyltransferase. They contain repeated copies of a six-residue hexapeptide repeat sequence motif (X-[STAV]-X-[LIV]-[GAED]-X) and adopt a left-handed parallel beta helix (LbH) structure. The active enzyme is a trimer with CoA and substrate binding sites at the interface of two separate LbH subunits. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients.	4.31903e-58
CP027254.2\|AVN21125.1\|839867_841301_+\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|180579	PRK06467, PRK06467, dihydrolipoamide dehydrogenase; Reviewed.	0
CP027254.2\|AVN21134.1\|870473_872204_+\|CapA-family-protein	gnl\|CDD\|214858	smart00854, PGA_cap, Bacterial capsule synthesis protein PGA_cap. This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.	6.68637e-55
CP027254.2\|AVN21128.1\|843930_844944_-\|tryptophan--tRNA-ligase	gnl\|CDD\|183400	PRK12282, PRK12282, tryptophanyl-tRNA synthetase II; Reviewed.	0
CP027254.2\|AVN21131.1\|847248_848751_+\|sodium:proton-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	8.49086e-41
CP027254.2\|AVN21129.1\|845152_846082_+\|DUF808-domain-containing-protein	gnl\|CDD\|377542	pfam05661, DUF808, Protein of unknown function (DUF808). This family consists of several bacterial proteins of unknown function.	8.88768e-143
CP027254.2\|AVN21139.1\|875447_875840_-\|RidA-family-protein	gnl\|CDD\|100005	cd02198, YjgH_like, YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	2.70604e-55
CP027254.2\|AVN21127.1\|842629_843520_+\|succinate--CoA-ligase-subunit-alpha	gnl\|CDD\|180194	PRK05678, PRK05678, succinyl-CoA synthetase subunit alpha; Validated.	0
CP027254.2\|AVN23733.1\|872998_873328_+\|methyltransferase	gnl\|CDD\|226219	COG3695, COG3695, Predicted methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	1.03205e-33
CP027254.2\|AVN21124.1\|838609_839806_+\|2-oxoglutarate-dehydrogenase-complex-dihydrolipoyllysine-residue-succinyltransferase	gnl\|CDD\|235571	PRK05704, PRK05704, 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase.	0
CP027254.2\|AVN21137.1\|874144_874582_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.16394e-31
CP027254.2\|AVN23732.2\|863915_868676_+\|type-I-secretion-C-terminal-target-domain-containing-protein	gnl\|CDD\|380150	NF012196, Ig_like_ice, Ig-like domain-containing protein. This variant form of the Ig-like domain occurs as a repeat in a number of large adhesins, including a 1.5-MDa ice-binding adhesin, the Marinomonas primoryensis antifreeze protein.	7.56698e-09
CP027254.2\|AVN21123.1\|835769_838610_+\|2-oxoglutarate-dehydrogenase-E1-component	gnl\|CDD\|236499	PRK09404, sucA, 2-oxoglutarate dehydrogenase E1 component; Reviewed.	0
CP027254.2\|AVN21135.1\|872200_872917_-\|metalloprotease	gnl\|CDD\|239806	cd04279, ZnMc_MMP_like_1, Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.	4.34401e-05
CP027254.2\|AVN21126.1\|841448_842615_+\|ADP-forming-succinate--CoA-ligase-subunit-beta	gnl\|CDD\|234813	PRK00696, sucC, ADP-forming succinate--CoA ligase subunit beta.	0

>CP027254.2|AVN21131.1|847248_848751_+|sodium:proton-antiporter
MGNFFLLQAFTVVFALSIATTIFNKRILGFPQAIGVPLVSAIFVFILQWGASLLNGNQFITINIHNIEEAVRHIDFYDFLINGVICFILTSSALKFKISDLKSYWKQISILATIALVLCAVLFGSLLYGFQLLVGYHVPILVLLLLGAALGATDPIGIKGVLSSIRAPHHLIVKLEGESLFNDAMCIALFMTLLNVLQGEHFSLVATLEALLYEIVVAVGIGWAFGVGVLRLLRGKHEMESLILTTALLASGAYLVALFAHASAPIACVIGGLIVGNKWKEIREEREIQEVNHFWHTVEGIINSFLFTLIGLELFILDLNFSLILGGIVAFFILHISRFAANFMAFAFFPTMRRTKSYNGSLTILSWGGVRGGISLALILAVANIPALSPYSSILIGYTFISVLLSGIVCGLGLPAVMNAFYYNPNEETEGLKGFYQRLCHKMNRRGFQYIVGEDALGRETITVYNPDILVDQKTEDGIATMHDPNKLQEVKRFESPDNF
>CP027254.2|AVN21130.1|846109_847009_+|neutral-zinc-metallopeptidase
MRWKGRRISSNVEDRRGGGGVRAGGISIIGLVVAFVAWKFFGVDPQQAYQATQQVTASQQSNATAPESLTAEQKEASDFVGTVLADTEDTWTPIFKQLGKSYTPPTLVLFSGMVQSGCGTAQSAMGPFYCPADQKVYIDTEFFKDMRQQMGISGEQNQTELSREDQAGDFAQAYVVAHEVGHHVQTLLGISSQVQQARAQVSQREGNQLSVRQELQADCLAGIWASHNQQRTQFLEQGDIEEAMDAAQKIGDDYLQKRSTGQVVPDSFTHGSSEQRMHWFQVGLKTGDINQCDTFNNPV
>CP027254.2|AVN21129.1|845152_846082_+|DUF808-domain-containing-protein
MASGLLLLLDDIATILDDVALMSKMAAKKTAGVLGDDLALNAQQVTGVRADRELPIVWKVAKGSFVNKLILVPLALLISVIAPWLINPLLMLGGLFLCYEGVEKVLHTIMHKKASTSEEAKAELETEELDLATFEKEKIKGAVRTDFILSAEIVVITLGTVATATLMTKLSVLSVIAVVMTIGVYGLVGMIVKIDDLGLYLTEQSTSFKQTIGRGLLAFAPILMKLLSIVGTIAMFLVGGGIINHTIPLLHHLTEDTVDHVETIPAVGNIIGALTPTLINFGIGLVAGAIVLLIVSLIQKMWPKKASGS
>CP027254.2|AVN21128.1|843930_844944_-|tryptophan--tRNA-ligase
MSNVDQRPIILTGDRPTGQLHLGHFVGSLRSRVGLQDSHHQHLLLADAQALTDNADNPDKVRRNILEVALDYLAVGIDPTKTTICVQSCLPALNELTMLYLNFVTVARLERNPTIKSEIQMRGFERDIPAGFLCYPVAQAADITAFKATVVPVGEDQIPMIEQTNEIVRRVNRQIGQDLLPECKALLSNMARLPGFDGKAKMSKSLGNTIVLNASDKDIKKAVNAMYTDPNHLRIEDPGQVEGNIVFTYLDAFDPNKEEVEELKAHYRRGGLGDGTVKKRLEGVLKELITPIRERREELAKDPDYIMDVLRQGTDKCRLITQQTLDEVKDGLGLFKF
>CP027254.2|AVN21127.1|842629_843520_+|succinate--CoA-ligase-subunit-alpha
MSVLINKDTKVLVQGFTGKNGTFHSAQALDYGTKVVGGVTPGKGGTTHLDLPVFNTMKEAVGETNADASVIYVPAPFVLDSIVEAVDSGVGLIVVITEGVPTIDMLKAKRYLETNGNGTRLVGPNCPGVITPGECKIGIMPGHIHQPGRIGIISRSGTLTYEAVAQTTKLGLGQSTCIGIGGDPIPGMNQIEALQLFQDDPDTDAIIMIGEIGGTAEEEAAEFIKSNVTKPVVGYIAGVTAPKGKRMGHAGAIISGGQGTAEEKFAAFEKAGMAYTRSPAELGSTMLQVLKEKGLA
>CP027254.2|AVN21126.1|841448_842615_+|ADP-forming-succinate--CoA-ligase-subunit-beta
MNLHEYQAKALLKEYGMPVQEGILATNADEAVAAFEQLGGKFAVMKAQVHAGGRGKAGGVKVAKSKEDVIEFANNIIGTRLVTYQTDANGQPVNSIIVAEDVYPVERELYLGAVVDRSSRRITFMASTEGGVEIEKVAEETPEKIIKVEVDPLVGLQPFQAREVAFALGLKDKQINQFVKIMTAAYQAFVENDFALFEINPLSVRENGEILCVDAKVGIDSNALYRLPKVAALRDKSQENERELKASEFDLNYVALEGNIGCMVNGAGLAMATMDIIKLYGGQPANFLDVGGGATKERVIEAFKIILADTSVQGVLINIFGGIVRCDMIAEAIIAAVQEVNVTVPVVVRLEGNNAELGAKLLDESGLKLISANGLSDAAEKVVAAVKA
>CP027254.2|AVN21125.1|839867_841301_+|dihydrolipoyl-dehydrogenase
MSQQFDLVVIGGGPGGYEAAIRAAQLGFKVACIEKRIHNGKPSLGGTCLNVGCIPSKALLDSSHRYEDTVHHLADHGITTGEVNFDLAKLLARKDKIVDQLTGGIDQLLKGNGIEWLKGTGKLLAGKKVEFVSHEGETQVLEPKYVILASGSVPVNIPVAPVDQDIIVDSTGALNFPEVPKRLGVIGAGVIGLELGSVWRRLGAEVVVFEAMDAFLPMADKALAKDYQKLLTKQGLDIRIGAKVSGTEINGREVTVKYTQGGEEKTQTFDKLIVCVGRKAYAEGLLADDSGIKLTERGLVEVNDHCATSVEGVYAIGDLVRGPMLAHKAMEEGVMAVERIHGHAAQVNYDTIISVIYTHPEAAWVGLTEEQAKEKGHEVKTGQFGFAVNGRALAAGEGAGFVKFVADAKTDRLLGMHVIGPAASDIVHQGMIALEFVSSVEDLQLMTFGHPTFSEVVHEAALAVDGRAIHAIQRKRK
>CP027254.2|AVN21124.1|838609_839806_+|2-oxoglutarate-dehydrogenase-complex-dihydrolipoyllysine-residue-succinyltransferase
MATEIKAPVFPESVADGTIATWHKKVGEPVSRDEVICDIETDKVVLEVVAPADGSLVAIIKDEGDTVLSDEVIAQFEAGAGAAAAAPAAVEQAVAHTQAGAAPVVERTETVSDQAPAVRKALTESGIAAADVQGTGRGGRITKEDVANHQAKPAANVTPLSVAVGERIEKRVPMTRLRKRVAERLLAATQETAMLTTFNEVNMKPIMELRKQYKDAFEKRHGARLGFMSFFVKAATEALKRYPAVNASIDGDDIVYHGYYDIGVAVSSDRGLVVPVLRDTDRMSYAEVESGIGAYAAKARDGKLSIEEMTGGTFTITNGGTFGSLLSTPILNQPQTGILGMHKIQERPMAVNGQVEILPMMYLALSYDHRMIDGKEAVGFLVAIKELLEEPAKLILDL
>CP027254.2|AVN21123.1|835769_838610_+|2-oxoglutarate-dehydrogenase-E1-component
MQEVADALRLDTELSADSAAYIEELYEQYLTSPTSVAEDWRQYFDKYPKGDQPHSTVREQFLLLGRNANRVQPVVQSTVSTEHERRQIGVLQLIAAYRNRGHQKAKLDPLGLAKREEIPDLDLSAHGLTKSDLDTVFNTGNLEIGKSEATLAEMIEAMESIYCGSIGVEYMHIVDTKEKRWIQQRLESARGKFNYTNDQKKGFLERLTAAEGLEKYLGNKYVGAKRFGVEGGESFIPMVNEIIQRAGAVGCKEVVIGMPHRGRLNLLVNIMGKNPADLFGEFEGKSIHKKGSGDVKYHQGFSSNVMTPGGEVHLALAFNPSHLEIVGPVVEGSVRARQVRRRDIGGDDVLPVIVHGDAAFAGQGVNMETFQMSQTRGYTVGGTVHIIVNNQVGFTTSDPRDARSTEYCTDVAKMIQAPIFHVNGDDPEAVIFATQLAHDFRHEFRKDVVIDLFCYRRRGHNEADEPSGTQPLMYQVIAKKATTRTLYADQLVQEKVLDRAEADQMVEDYRSDLEAGNHVANALILEPNTKMFVDWTPYLGHDYTDDWDTSFDLNRLKELGEGMSKLPEGFVMQRQVQKVIEDRVKMQTGETPLNWGAAETLAYATLLDEDYLVRITGEDVGRGTFSHRHAKLHNQADGSTYIPLCHVKENQPRFAIYDSLLSEEAVLAFEYGYATTIPKSLIIWEAQFGDFVNCAQVVIDQFIASGETKWERVCGLTMLLPHGFEGQGPEHSSARLERFLQLCAEDNMQVITPTTPAQIFHALRRQAVRPIRKPLIVMSPKSLLRHKLATSTLEELANGSFQTVIDEIDQINKSDVTRLVLCGGKVYYDLLEKRREQNLTNVAIVRIEQLYPYPEQRLAEILASYPNVKELVWAQEEPKNQGAWLFIAPRLYDDILKSGKQIRISFAGREASAAPACGSPYLHAKQQAQLINDALAIEAEQSGDSQ
>CP027254.2|AVN21122.1|835632_835767_-|hypothetical-protein
MDPFPIAKNITGCLLSTPMMHNAKLVKKALVTQQVSKTMGRHTT
>CP027254.2|AVR49325.1|862627_862954_+|hypothetical-protein
MNINGTNYTVTAADLANGFITAAIPVTGEGPVTIHAEAVDAQGNLDVADADVTVTVDTLPADLIGAITIPEDLNGDGILNADELGTDGTFNAQVALGPDAIEWHSSEC
>CP027254.2|AVN23732.2|863915_868676_+|type-I-secretion-C-terminal-target-domain-containing-protein
MTAADLANGFITAAIPVTGEGPVTIHAEAVDAQGNLDVADADVTVTVDTLPADLIGAITIPEDLNGDGILNADELGTDGTFNAQVALGPDAIDGTVVNVNGTNYTVTAADLANGFITAAIPVTGEGPVIIHAEAVDAQGNLDVADADVTVTVDTLPADLIGAITIPEDLDGNLILNADELGTDGTFNAQVALGPDAIDGTVVNVNGTNYTVTAADLANGFITATLAATAADPVTGQIVIHAEAVDAQGNVDVADADVTVTLDVTPPDITTTVLAIDPVTADNILDATEAGGSVTLTGTLTNIPTDAVTTGVVVTVNGVDYTATVDAVAGTWTVDVAGSGLAADSDLTVDATATFTDLAGNASTLQDTQTYTLASSIIAFDNTDTAVLAPQPLLVQDGASLGSETYLALVSLAGLDLQLGSEAIDFTVGAGQEGNATFTYSALLGADVLSDYSLVLQKLDPITGDWTSVYGGGEADILDLTLLGGTPSVVIDGLEEGQYRAFMTYNGLLGIGLLGTLTGTMDVYDTTQVGGYYTEVADGNVITDINTSGETDVVTAMTVVTAVNGQPVTALDTVINGLYGTLVIDPDGTYTYTPTASAAGVGQTDVFVYTLTDPVTGDTAQANLNIQLSSVKAVDNVVTAEINPEPLLVADDVALGSASYLVAVSLAGLDLQLLGNDAIEFTVDPNREGTATFTFDAIITADLLSNYAIVVQKFDEATGQWVSIGGTNPEASLIDLTLIGGTPTAVLEGLDAGQYRAFIGYEGLVGVGLGGTLTGTMDVYNPYIVAGYSVEPISGNVIKDASLTGEVDAASSSAVISQVNGVAVDPVAGATIVGAYGTLVIDQDGNYTYTPTVDGANLGQVDQFTYTLLDPVTGNTSEATLYVRLDSDSVDMTWNDADPSQPAVITSPLPVDAMDNVASAEIDMVYPVTTEVLDNAISYNWLLGVGGIVIGSKEGTATFTVDPGNLTDAIIAVNFGSVATVVDGLHVVLTRVNPDGTRTVVADSSDTGVIDLLGIFGSEVQFKIDNLSAGTYELFMESNTLLTALGSVTADITLNHGDITQPPVLVVDPVTGNVLADDNSAVYGTNYVPDYITTTSVVTAVTAENGNTTTVVAGTPATVVGVYGTLTINADGTYSYQATADMANVGKVDSFTYTVTDPVTGRTDTATLHVQVGSPDVDVTWNTADPSADATLPTPSVTADTDDATISMEPVVDPVVDVASGNVTIGNLAGFPPLPVLSSTVTSSQFTIAANTVSDVHVQLNYTASLSLSALPTTGYTIQQLVGGTWVNTAYSGSATALAGVLGAPAYSADVPHLSEGTYRVVFSLSSLISLGTVTLDSVVTTTATHLDQYTPDGQTDWITGNVLTNDVVEGTQLYVMNSTTGTYELAAGQGVNTGEGTLYLYNDGSYFYKPLDSAANATVDVIDYKLVSVIDGSEYASTLTINLSQELNSLAVSTAANDTFALGNGSDTLIYNTLTAASVTNATGGNTTAGGVDVWTDFHVGNTATDDQADKIDLSNLLIGSQTNLTIGQYVSVSYDAGTQTATISVDRDGGLLVEGTYTETPLLQLTNLTGPVTLNDLINNGQIIF
>CP027254.2|AVN21133.1|868821_870477_+|poly-alpha-glucosyltransferase
MKAFLNFQRQLNLWLEHIAPHVSDLQKKTILFISYGPKDQRCNVWHSKKTSFSQAKIQLLAFINDQFAQELLTDYIKIDVAYNLTKQAWKVVEQQVHHQFHNNHYRKGIGFDEHCSVAFLEQEIYGKAIIRGLSYDKPNFFDETNLNYSIKQKYNATKPQIKLQELQDIWTFDTYAAFYENGQFINLASGYDANGIRAISSNKKQHFQSLIEKNSAFLHDQIQENGKFIYGYFSAYDRDIRNYNTVRHCTSVYALLETFEVQSKPEYWPKIHAAIQYALTNFYKEKDSETAFMIDGKEGEFEIKLGANAAAILMFTKYQEITQKTDYQKYAEKLANGILKLVDSNGSTTHVLNYPDYDLKEKFRIIYYDGEAALALLRLYQINQDSRLLETVKLMFECFIEKRYEKYHDHWLSYCTNELTKICPEDKYFIFGLNNYLKHFIFIRNRKTTYATLLEMLMAAYKMVNRLKEQGHTALFEQAYMPELQKLIEFRADFQTTGFFYPEMAMYMARPDKILHAFYIRHDRFRVRIDDQEHNLSGYIAYVKDYKGDES
>CP027254.2|AVN21134.1|870473_872204_+|CapA-family-protein
MKYQPVEIKLLAHIDTTSFDEALWQFEFDDDISTLLLIDYALEQFQQKKVQAQDVYIVPQKMSEQIGQQNLGLKTSEIYTFTELLQFIIFTQAVDVKEALSNMLCGTNEQASLIFSKRAAAYNLKLKNEATQNQLKHLFLLLRKIYSYPNEIKKVFFIKELNFQGKSYLPQTPLMGQNVVEVLYLTNPFRKIYLTFFEENQTIGFFLFLDDIHRAEHLVPYYACFQAQNVQPKVCSAPSGIINILGDTYFGEIYTKKRKARGQTDALQQYGYDYSFKKIKAFLGEHDLNIANFEAVFSLENQSPLGHKKSFILKADAEQTLAAFKNIHLNHVVLANNHLKDYGDRGLTYTLQQLDQANISYIGAGVNQKDAHNYFELSFENKRYAIFNGYWYRDTPYLDYNFYALGHKSGVACLNGVLLEQIGRYRLAHPEHKIIVICHWGVDFKPITKEQNKLAAILTQAGADLIIGHGAHTIQPIQIINQKPVVFGIGNAVFNSNGEYEKHNALPFGCIARLDLSKDLLRLYPIYINNLKTFWQPYPVDAEDFLKASTYMTSSLTLENYIATQDNLGAYIEIKF
>CP027254.2|AVN21135.1|872200_872917_-|metalloprotease
MKKTLLVITGTLLCVSCTTRPPLPLGETPKVSTDGRPIIPVTFVFTTNSPEATKFDNYQQMRKEIKILNKYYVDDKNNKIFKFKLHRYIPYEEFSKLHCDLKQQINQPYPITIETIPASVNTCFPKRTASKEVIVFIYDAYSTKWKFEDVTSRAFRNNGKPFILLDWNRLNYNIQAGSVHEMGHVFGLKHVCAPKATKRTPTNIMASAECKLGSGGLRNLGFTPVQLQTILSTYKQYP
>CP027254.2|AVN23733.1|872998_873328_+|methyltransferase
MESILTTQYELHRQILEVIALIPYGKVATYGQVARMAGLPKHARLVGYVLKHLEADHQVPWYRVINSQGKISLSKFNEKGENIQQLKLEAEGVYLLNGKVDLKQFAWQP
>CP027254.2|AVN21136.1|873353_874103_+|hypothetical-protein
MQKNNKWCSGAVLLLSLMAQVSYAEKDISTQPFANIKASQQDIDLICKQMRQKCSGDAILWKGKNTQDSIYYLIDESPQIVQVKKQNNQYKVVDQWDFKDYQHNNKEPHTDDLAPDGLQIFPALYPLNKNGYAIAVVNRWFTGYSGGGRFEENADFIKLKPHGEYQVALKDIAFSSREMIRACFSEQDYKKSPHCHDEAWMILNIQFKDVGQPYYLWQLNYKNYSWEAFKSKKTITVEQSREEVMPFKK
>CP027254.2|AVN21137.1|874144_874582_-|universal-stress-protein
MLYQHLLVPIDGSETSMVAMKEAIKLGKALNSKITVVQVMALDPFIADVYVKTGQTNELIERTRTYLLDILEKAKQEFAKEGITVETKLLEGFVVHEEIIQAAQDLNADLIVMGSHGRTGVRKLVLGSVAQKVLGESHIPVLIVR
>CP027254.2|AVN21138.1|874703_875336_-|chloramphenicol-acetyltransferase-CAT
MAEKLISSPVRHWCEFEFISKTVKNPNIHIKGNYSYYSAYWDQGFERCVVRYLHDKASTPEKPIDQLYIGNFACFGAECVIMMGGNQLHRPDWISTFPFDTRSFLAAGDTIIADGCWIGSRAMIMQGVKLGEGAVVATGAVVTKDVPPYAIVGGVPAKIIKYRFPQEQIDKLLALKLYDLDEKQILKIREYLQTDDIDALSTHIENLRNL
>CP027254.2|AVN21139.1|875447_875840_-|RidA-family-protein
MRTAIFPKDRHALYEQHGYSAAIQSKDLLFVSGQVGSLEDGSPIPDFEKQVIQAFKNLAETLKAAGCTFDDIIDVTTFHTDSERQFESIMKVKNQIFTQKPYPNWTAVGVTWLAGFDFEIKVIARIPHNN

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Crispr_ID: CP027254_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP027254_3

1952885-1952998

Orphan

Consensus_repeat	Method
CGCTTCTCAGGACAAAGCGTTGCTTTACTTATCCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP027254_3

>merge|CP027254|3|1952885-1952998|CRISPRCasFinder
CGCTTCTCAGGACAAAGCGTTGCTTTACTTATCCTCTTCCACTCGAACATAGTTCTCGTCTTCTTGCGAAGCTTTAACCGCTTCTCAGGGCAAAGCGTTGCTTTACTTATCCTC

>CP027254|3|2|1952885-1952998|CRISPRCasFinder
CGCTTCTCAGGACAAAGCGTTGCTTTACTTATCCTC	TTCCACTCGAACATAGTTCTCGTCTTCTTGCGAAGCTTTAAC
CGCTTCTCAGGGCAAAGCGTTGCTTTACTTATCCTC

Protein	Signature genes	Signature genes Name	Protein_function
CP027254.2\|AVN22036.1\|1949939_1950857_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|273359
CP027254.2\|AVN22033.1\|1947822_1948431_-\|FMN-dependent-NADH-azoreductase	unknown	unknown	gnl\|CDD\|234675
CP027254.2\|AVN22047.1\|1962694_1963714_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
CP027254.2\|AVN22034.1\|1948526_1948922_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
CP027254.2\|AVN22030.1\|1942198_1944403_-\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|273805
CP027254.2\|AVN22045.1\|1959743_1961147_-\|dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|235798
CP027254.2\|AVN22048.1\|1963727_1964690_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	unknown	unknown	gnl\|CDD\|238958
CP027254.2\|AVN22037.1\|1950890_1951895_-\|homoserine-dehydrogenase	unknown	unknown	gnl\|CDD\|168683
CP027254.2\|AVN22040.1\|1954655_1955351_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293810
CP027254.2\|AVN22043.1\|1957843_1958902_-\|butanediol-dehydrogenase	unknown	unknown	gnl\|CDD\|176195
CP027254.2\|AVN22042.1\|1956883_1957795_+\|bestrophin	unknown	unknown	gnl\|CDD\|376448
CP027254.2\|AVN22049.1\|1965052_1966039_+\|lipoyl-synthase	unknown	unknown	gnl\|CDD\|237261
CP027254.2\|AVN22041.1\|1955542_1956814_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225114
CP027254.2\|AVN22035.1\|1948918_1949773_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|227311
CP027254.2\|AVN22044.1\|1958931_1959717_-\|3-oxoacyl-ACP-reductase	unknown	unknown	gnl\|CDD\|187624
CP027254.2\|AVN22032.1\|1946389_1947739_+\|chromate-transporter	unknown	unknown	gnl\|CDD\|273350
CP027254.2\|AVN22031.1\|1944919_1946206_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|182433
CP027254.2\|AVN22029.1\|1940725_1942144_+\|aspartate-ammonia-lyase	unknown	unknown	gnl\|CDD\|237031
CP027254.2\|AVN22038.1\|1952004_1952796_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
CP027254.2\|AVN22046.1\|1961157_1962693_-\|diaminohydroxyphosphoribosylaminopyrimidine-deaminase	unknown	unknown	gnl\|CDD\|237001

Protein	Function_ID	Function_description	E-value
CP027254.2\|AVN22036.1\|1949939_1950857_+\|EamA-family-transporter	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	6.73638e-15
CP027254.2\|AVN22033.1\|1947822_1948431_-\|FMN-dependent-NADH-azoreductase	gnl\|CDD\|234675	PRK00170, PRK00170, azoreductase; Reviewed.	1.57248e-84
CP027254.2\|AVN22047.1\|1962694_1963714_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	7.15262e-167
CP027254.2\|AVN22034.1\|1948526_1948922_+\|transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.15826e-39
CP027254.2\|AVN22030.1\|1942198_1944403_-\|TonB-dependent-siderophore-receptor	gnl\|CDD\|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	5.33284e-104
CP027254.2\|AVN22045.1\|1959743_1961147_-\|dihydrolipoyl-dehydrogenase	gnl\|CDD\|235798	PRK06416, PRK06416, dihydrolipoamide dehydrogenase; Reviewed.	0
CP027254.2\|AVN22048.1\|1963727_1964690_-\|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha	gnl\|CDD\|238958	cd02000, TPP_E1_PDC_ADC_BCADC, Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).	1.46231e-132
CP027254.2\|AVN22037.1\|1950890_1951895_-\|homoserine-dehydrogenase	gnl\|CDD\|168683	PRK06813, PRK06813, homoserine dehydrogenase; Validated.	2.12235e-76
CP027254.2\|AVN22040.1\|1954655_1955351_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293810	cd07724, POD-like_MBL-fold, ETHE1 (PDO type I), persulfide dioxygenase A (PDOA, PDO type II) and related proteins; MBL-fold metallo-hydrolase domain. Persulfide dioxygenase (PDO, also known as sulfur dioxygenase, SDO, EC 1.13.11.18) is a non-heme iron-dependent oxygenase which catalyzes the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria. Mutations in ethe1 (the human PDO gene) are responsible for a rare autosomal recessive metabolic disorder called ethylmalonic encephalopathy. Arabidopsis thaliana ETHE1 is essential for embryo and endosperm development. Bacterial ETHE1-type PDOs are also called Type 1 PDOs. Type II PDOs (also called PDOAs), are mainly proteobacterial. These enzymes belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	9.98336e-86
CP027254.2\|AVN22043.1\|1957843_1958902_-\|butanediol-dehydrogenase	gnl\|CDD\|176195	cd08233, butanediol_DH_like, (2R,3R)-2,3-butanediol dehydrogenase. (2R,3R)-2,3-butanediol dehydrogenase, a zinc-dependent medium chain alcohol dehydrogenase, catalyzes the NAD(+)-dependent oxidation of (2R,3R)-2,3-butanediol and meso-butanediol to acetoin. BDH functions as a homodimer. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The medium chain alcohol dehydrogenase family (MDR) have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose. Sorbitol dehydrogenase is tetrameric and has a single catalytic zinc per subunit.	0
CP027254.2\|AVN22042.1\|1956883_1957795_+\|bestrophin	gnl\|CDD\|376448	pfam01062, Bestrophin, Bestrophin, RFP-TM, chloride channel. Bestrophin is a 68-kDa basolateral plasma membrane protein expressed in retinal pigment epithelial cells (RPE). It is encoded by the VMD2 gene, which is mutated in Best macular dystrophy, a disease characterized by a depressed light peak in the electrooculogram. VMD2 encodes a 585-amino acid protein with an approximate mass of 68 kDa which has been designated bestrophin. Bestrophin shares homology with the Caenorhabditis elegans RFP gene family, named for the presence of a conserved arginine (R), phenylalanine (F), proline (P), amino acid sequence motif. Bestrophin is a plasma membrane protein, localized to the basolateral surface of RPE cells consistent with a role for bestrophin in the generation or regulation of the EOG light peak. Bestrophin and other RFP family members represent a new class of chloride channels, indicating a direct role for bestrophin in generating the light peak. The VMD2 gene underlying Best disease was shown to represent the first human member of the RFP-TM protein family. More than 97% of the disease-causing mutations are located in the N-terminal RFP-TM domain implying important functional properties. The bestrophins are four-pass transmembrane chloride-channel proteins, and the RFP-TM or bestrophin domain extends from the N-terminus through approximately 350 amino acids and contains all of the TM domains as well as nearly all reported disease causing mutations. Interestingly, the RFP motif is not conserved evolutionarily back beyond Metazoa, neither is it in plant members.	2.35864e-81
CP027254.2\|AVN22049.1\|1965052_1966039_+\|lipoyl-synthase	gnl\|CDD\|237261	PRK12928, PRK12928, lipoyl synthase; Provisional.	0
CP027254.2\|AVN22041.1\|1955542_1956814_+\|sigma-54-dependent-Fis-family-transcriptional-regulator	gnl\|CDD\|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	1.04762e-122
CP027254.2\|AVN22035.1\|1948918_1949773_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|227311	COG4977, COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription].	4.38745e-34
CP027254.2\|AVN22044.1\|1958931_1959717_-\|3-oxoacyl-ACP-reductase	gnl\|CDD\|187624	cd05366, meso-BDH-like_SDR_c, meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs. 2,3-butanediol dehydrogenases (BDHs) catalyze the NAD+ dependent conversion of 2,3-butanediol to acetonin; BDHs are classified into types according to their stereospecificity as to substrates and products. Included in this subgroup are Klebsiella pneumonia meso-BDH which catalyzes meso-2,3-butanediol to D(-)-acetonin, and Corynebacterium glutamicum L-BDH which catalyzes lX+)-2,3-butanediol to L(+)-acetonin. This subgroup is comprised of classical SDRs with the characteristic catalytic triad and NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	2.5012e-113
CP027254.2\|AVN22032.1\|1946389_1947739_+\|chromate-transporter	gnl\|CDD\|273350	TIGR00937, Chromate_transport_protein, chromate transporter, chromate ion transporter (CHR) family. Members of this family probably act as chromate transporters, and are found in Pseudomonas aeruginosa, Alcaligenes eutrophus, Vibrio cholerae, Bacillus subtilis, Ochrobactrum tritici, cyanobacteria and archaea. The protein reduces chromate accumulation and is essential for chromate resistance. [Transport and binding proteins, Anions].	7.57664e-60
CP027254.2\|AVN22031.1\|1944919_1946206_+\|MFS-transporter	gnl\|CDD\|182433	PRK10406, PRK10406, alpha-ketoglutarate transporter; Provisional.	6.94672e-167
CP027254.2\|AVN22029.1\|1940725_1942144_+\|aspartate-ammonia-lyase	gnl\|CDD\|237031	PRK12273, aspA, aspartate ammonia-lyase; Provisional.	0
CP027254.2\|AVN22038.1\|1952004_1952796_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	7.30352e-23
CP027254.2\|AVN22046.1\|1961157_1962693_-\|diaminohydroxyphosphoribosylaminopyrimidine-deaminase	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	3.94652e-113

>CP027254.2|AVN22038.1|1952004_1952796_-|sulfite-exporter-TauE/SafE-family-protein
MLLLVVEGIVIGFLLGLTGAGGGILAVPALMTSQGWSVAQAAPIGLLAVALSTLIGTIEGLFKKIVRYRAAIWIALIGAPMAHIGILIANAISPVWLMLMFSLVMFTVGYRLISNRVSDFHNPPCQVNPSTGRFIWNFKTGGVLAGIGIIAGLLTGMLGVGGGFVIVPALRKVTNLDMHSIVATSLMIIFLISGMSIVMHIAEGFHYPVGITSAFALACAVGMLLGRRAIRFIPSAIVQKVFALMVFAVAIYMVIKIVNLTNI
>CP027254.2|AVN22037.1|1950890_1951895_-|homoserine-dehydrogenase
MKRVNLAICGFGRIGQQIAELLLNRTTYYKQKYQIDARLVGVCNSSSGLIDQEGLQASKWLDKTQYQAGLTEQKFLEQVQADVIIETGPSDYVTGGKGLFYLDYALTHSMNAIAVSKGALVVDGKKLVNLAPQHNKKLFFSGATAAALPTVDLFEYNLAGCQILEIEGVFTGTTNFILNDMLQHECAFAESLEKAQAKGIAEPDSSFEVDGWDTAAKITILANTVLGADVKIQDIPRQGISHVTADHIRDWKKENVIPRLVGFIHIKNQQIQTGVELRLVSANHPFAHLQGSNKCIRALTQEMGEFVVSGGASAPLATAAAALKDFELMLKTGC
>CP027254.2|AVN22036.1|1949939_1950857_+|EamA-family-transporter
MNILLYVAVVLIWGTTWIGIAVQSHYATPVVAILWRFAISALLLWVVLLFSGKLQRIALKDHLFCMLQGLCVFGLNFICFYTAVKYVNSGLESVIFSMAVFFNAINALIFFKQKPSPNFAPAAILGLIGIVLLFWHDLVNSQFNAQLLMGIGLCAVGTYGFSLGNMISVRHQKRGLNIFSTNCYAMTYGALVILSLALFTGQDLMPPMNFPFLSSVLYLAVFGTVIGFSAYFSLVGRIGAAKAAYSTLLFPLVALTVSTFFEGYVWALNAVFGILLILLGNYLMFSKLEIGKKLFNSQKNCEKQA
>CP027254.2|AVN22035.1|1948918_1949773_-|AraC-family-transcriptional-regulator
MAYQTLEQLQQSKAKLHETVVLDENMQLAFWSNQQDRVSVCSDHHTLSLYIQDGYESYQKTPAGWKNGGGPGRFCLLPEHQESTWDIRGGLKFVHLYYTDQHLRDVAEKIWDKEPNQIELNEVVFNDDERIRALYQFFLLDCDWQDSSNHLQMSTTASLLLNHLIRKYSSVQWQQPTIKGGLAPHKLKYIQEWIEDHLDQALTLSDLANVVNLSEYHFAHMFKQSMNMAPHQYVMQRRLTKAKGLIQSSQLSLQDIALVCGFSSASHLSHRFKQFYGMSPSQLR
>CP027254.2|AVN22034.1|1948526_1948922_+|transcriptional-regulator
MTVTIPHDIQSSDCQRVSQVLARVGEKWSILIVMTLASHPHRFSEIKRRINGISQRMLTLCLRGLERDGLVKRTVYPVVPPHVEYELTPLGHSLTEPVIALGQWAQQHIADIDAARAAFDAAQEKPITLDT
>CP027254.2|AVN22033.1|1947822_1948431_-|FMN-dependent-NADH-azoreductase
MELLQIDTSILGEQSVSRQLTSSVIRQLSTAYPDAEIIHHDFALEPIPHLSDAEFLAWQGVEPNNEIAQQRVARNTQYLDEFLSSDIVVIGAPMYNFSFPSQLKAWLDRLSVAGKTFRYTENGPQGLVEGKRVIIASSRGGVYSEGSPAEALDYQETYIKAFFNFIGVTDITFVRAEGIAFGPEARQAALDNAAAQIAQLAG
>CP027254.2|AVN22032.1|1946389_1947739_+|chromate-transporter
MENEKSPLPESIIQVTFWQAFLFWLKLGFISFGGPAGQIAVMHQELVEQKRWISEKRFLHALNYCMLLPGPEAQQLATYIGWLMHRTAGGLVAGILFVLPSLFILIGLSWVYIKFGDVPVIAGIFYGIKPAVTAIVFHATYRIGSRSLKNKFLWFVAIAAFLAIFVLKLPFPLIVLSAGIAGYLTSKKYPELFSSAAGHKSSQKDYGSAFIDDDTPPPEHAKFHWPRLAKLIFVAIALWLLPILALGAYFGWHHSYTQMAWFFTKAALLTFGGAYAVLPYVYQGAVNHFGWLSPTQMIDGLALGETTPGPLIMVVAFVGFLGGVNHSLLGFEHLFFAGALGAVIVTWFTFLFSFVFIFAGAPIIESTHNEIKFTAPLTAITAAVVGVILNLALFFSYHVLWPQGFSGHFDIVAAFITVGAFIALFRFNVNVLYVIFASALVGLAVTFFS
>CP027254.2|AVN22031.1|1944919_1946206_+|MFS-transporter
MTYTQEEKRSRIRGIVGAASGNLVEWFDFYIYAVFAAYFTQALTAPDMDSTTKSIYVWGVFAASFFMRPIGSWVFGRIADRHGRKKSMVISICLMALSSFLFAALPTYDQVGLFAPFLLLVVRLLQGLSVGGEYGAVATYMSELGLKGQRGFYSSFQYVTLSGGQLLASLLGVILLTFLSEQQLHDGGWRIPFVIGGIAAILSLLARSRLEETLSHQDSERKESGSLRELFKKHWKTFLLVVGYTSAGSLTFYVETVYSKTYLTNLGMDGKTVGYIMTFALFVYMCAQPVFGAISDRIGRRSSMLAFSLLSAIFIYPVMVIGMRAYIDSPIIIALLLIFMMMLLSFYTSISGLVKAEMFPPHVRALGVGFSYAVGNALFGGSAPSVALQFKAAGIENTFFIYVIVMLIICFLCSLALPKKPDYLEHDH
>CP027254.2|AVN22030.1|1942198_1944403_-|TonB-dependent-siderophore-receptor
MHGMAGSYSMERRSINLHFMTCSKTALASSIALITSVVYANEAEVSQLPTITVNATQNNDALYTSKKVNLSGFQTDDLKKVPASITTITSERIEDQHAKTLTDVIKNDSSLGDGYAAIGYYPNFVARGFALDLGSSYLINGHTIRGEQNVALENKEQVEILKGISAIQSGMSTPGGVVNYVTKRPADVKNIAVDANSEGGYTLATDVGGFINDSFGYRINLAHESIHPNVHHANGKREFGSVALDWKINERSKLLFDIEAQHQSQRSVPGYQLLDGQEVPTNVDQDRLLGYQSWSKPVVNNSVNASLKYQYAFNDQWNGTLSASQSRVVIDDNSAFPWGCYNDICEYSGLGNTFDKHGNYDIYDFRSPDDTRITNQFAAGLNGQFNTANIQHQIAFELQRTYKTLKHHTPLNVVVGTGNIYEDTIDYSPSSESLGDRYKALESDQTAFTISDRVQFNDQWSTLLGGKLIHLDEQTYNSDGQQSRDTDLNKFLPQLALMYSPTAGTNLYASYAKGLSDGGEAPWFANNALEVLSPKNSEQYEIGIKQQIRNFLVTAAIFDLKQDNQYSKVNAEGTFDFVSQGEQHNQGIELGLTGALTDKLDVSSGITYTKSRLVDIDNDSYKGHQTQNVPKVRATAQLSYKVPSVEGLRLLSGMQYSSSKYANKEGTAKVGGYSVFNIGAAYKTNFAGHDTTFRFNIDNLFNKKYWRDVGAFMGDDYLFLGNPRTAQFSTTFSF
>CP027254.2|AVN22029.1|1940725_1942144_+|aspartate-ammonia-lyase
MMNAEITTRIEKDLIGYREINNNDYYGVQTLRALENFNLTQSKVGNFPHLIKALAMVKLACAEANYNLKSLDQTKFEAIEYSCNQLIRGNFHDQFPIDMMQGGAGTSTNMNANEVLANVALEYMGHAKGQYQYLHPNNDINMSQSTNDVYPTAIRLGLLLSLDELNLPFNNLILSFRNKSQEFAHILKMGRTQLQDAVPMTLGQEFGAFAVTLQKDLEQINTLIPNVLAYMNLGGTAIGTGITTEYSYRELAIQALAKISGKKIKSAPDLIEATSDMGDFVLLSGLLKRTATKLSKIANDLRLLSSGPRTGINEINLEARQPGSSIMPGKVNPVIPEAMNLACFQIIANDLAVTLAAEAGQLQLNAMEPLIAFKLFESMDLLGKAMAMFQSKCIDTITANPEHCKALVENSIGIVTALNPYLGYETTTRIAKTANETGQSVLALVQNEGLLSAQMLDDILSINNMVKPKMSA
>CP027254.2|AVN22040.1|1954655_1955351_-|MBL-fold-metallo-hydrolase
MFFKQFFEKESSTYTYMLGCEETRGAVLIDPVASDIEIYARELEQHQFTLIYTLDTHVHADHITAADLLRERFHCKSVLHRNSEVSCGDILITHGCMLKVGNLSIEARYTPGHTNACTSYLVENMIFTGDALLIDGCGRTDFQQGSAGTLYDSIHRQLFSLPDDTIVYPGHDYKGRLSSTIGNERLNNSRLGQNRSREDFIKLMNNLNLPYPKQIDKALPANQACGSISQL
>CP027254.2|AVN22041.1|1955542_1956814_+|sigma-54-dependent-Fis-family-transcriptional-regulator
MAKLNFESEQDFFILFEQLKALFPNASLFLADTTTQAIHYKFNTDDISVENMAALIQDHHNQYLEINTPKMRKRFIYQEHDIYIAEHRIIGKLHILQPVSIENDIADQGELTEQLEDLAKVFNSCSPEMTRMFSIIQRVAITEFPVLVRGESGSGKELVAKAIHDYSQRKNKIFVAINCAALNSNILESELFGHVKGAFTGAIRDHKGVFERAAGGTLFLDEIAEIPLELQAKLLRVLETGEFTPVGGEKPIQANVRIITATHKALREEAKAGRFRHDLLYRLRVIPIFIPPLRERKVDIPLIVDQILKESSTQLDTMPRHVNQKAMQVLLNYDWPGNVRELKNTLLYALTMANGKDEIEVEDLPNELLNAEDYVKLPETNTELSPENVQAALEKYNHNLNMVANIFGISRTTLWRYRQKHKL
>CP027254.2|AVN22042.1|1956883_1957795_+|bestrophin
MIVRDKSNVFKLLFAWKGTILPKVLPALSFVVLISACVVWLSYYHWIQIPTVPAIGFTIFGVILSICTGFRNNACYDRWWEGRKLWGALIANARHIVRDSHVLTNEQREHLIHQVLIFSNLLRDRLRQQTVEPTKFLEHAYLNNSSLNYLNEHINAPQFVLENIQKDLVKILKDGEISDIIYSTLNRHIIELGNIQAGCDRIAGTPLPYSYSVLLHRAVYCFCFILPFSLEAALGIWTPLIVGLIAYMFLGLDALSAQIEEPFGLQENDLPLDSIVRLIERESLSSLGQPLPPIIEAQNNNLL
>CP027254.2|AVN22043.1|1957843_1958902_-|butanediol-dehydrogenase
MKAARFYDRGDIRIEDIPEPEVTPGTVGIKVAWCGICGTDLHEFMEGPIFIPPCGHPHPISGESAPITMGHEFSGVVYAVGKGVDDIEIGQHVVVEPYIVSDDVPTGPGDNYHLSKNMNFIGLGGRGGGLSEKIAVKRRWVHPISNKIPLDQAALIEPLSVGHHAYVRSGAKAGDIALVGGAGPIGLLLSAILKAKGLKVIITELSAKRKEKAKESGVADYILDPSEVDVVSEVMKITNGDGVDVAFECSSVNKVLDTLVAAVKPTGVIVIVSIWSHPASINVHSVVMKELDVRGTIAYVNDHEETIKLVEEGKINLEPFITQRIQLDDLISQGFETLIHNNESAVKIIVHP
>CP027254.2|AVN22044.1|1958931_1959717_-|3-oxoacyl-ACP-reductase
MVKGLKNKVVLVTGAAQGIGRGIALRLAQEGAHIALVDMKQDQLNDVQQEIQALGVNASIFIANVSDREQVYAAINHAEQTLGGFDVMINNAGIAQVQAIADITPDEFQKIVDINIGGVLWGIQAAAAKFKQRQHKGKIINACSIAGHDGFALLGIYSATKFAVRALTQAAAKEYASHGITVNGYCPGIVGTDMWVEIDKRFAEITGAAIGETYKKYVEGIALGRAQTPDDVAALVAFLASNDSDYITGQSILTDGGIVYR
>CP027254.2|AVN22045.1|1959743_1961147_-|dihydrolipoyl-dehydrogenase
MSEAQFDLIVIGAGPGGYVAAIRAAQLGLKTAIVEEQHLGGICLNWGCIPTKALLAGAELATQFKHSGQFGFQVSQLDFDIQKLVQHSRQVSAQLVQGIDYLLKKNHVTVFNGRAQLTAKEKIEVTDAQGKSQALSAPHIILATGAKARHVPQLPVDGTYVWSYKEALVPEDLPKSLLVVGSGAIGSEFASLYQDLGCQVTLIDLAKQILPTEDAEVAQFVRKQFEQKGMKVLTDAVVQSIQIVNGQVHCVIETANDVQTIVFDRVLSAIGVQPNATGLGLEHLGVELNPQGFVAIDDYCKTNVAGLYAIGDVAGAPCLAHKASHEAMICVEKIAGVANVHSLDRSQIPGCIFTHPQVASIGLTENAAKAQNLPIRIGKFSLTANGKALAIGDASGFVKTVIHAETGELLGAHMVGHEVTEHIQGFAIAKYLEATDESLAQVIFPHPTLSEAMHESILASMQRAIHM
>CP027254.2|AVN22046.1|1961157_1962693_-|diaminohydroxyphosphoribosylaminopyrimidine-deaminase
MSEIKTLEIPKWGLSMEEGTIAQWLIKEGDSFNKGDEICEIETTKIVNVLEAPFAGTLRKILAKDGDTLPVGGLIAVCADSEISDAEIEQFIASLGGSAAKAPETPSEQSKAETFAPVTEKAEQPQPVAASASVPVKTAKGDYAVPESLQGYQASDELFTTPHALKLAEKHNVNLAKVTGSGREGRISVQDIQKAVQAAGGQWPDVKQQTQTKVVKSTADDSQILATPVARRLAKQWGINLNDCRVSGTRGRVCKEDVEAVYYRNNPTSVNEQPVQCAAQPQSTVTTVAMNGMRKAIASRLQAAKRNAPHFRLVVDLNVEALQKLRKQINETVPQVKLSINDMLIKAAAAALIKVPEVNVQFDEATQSILQFSQADISVAVAIPNGLITPIVKAANQKSLAQISDDMRDLATRAKTGKLQPDEFQGGSFSISNLGMLGIKQFDAIINPPQGAIMALGASESRAVVENGNVVVREIVTATLSCDHRVIDGAVGAKFLASFKQFVENPALILV
>CP027254.2|AVN22047.1|1962694_1963714_-|alpha-ketoacid-dehydrogenase-subunit-beta
MPNKSFRNAIKEAIESEMRRDPTVFVVGEDVRGGHGGKNTEENELEGFGGVLGVTKGLWTEFGSERVIDTPITESAIIGMAAGAAATGLRPVADLMFMDFYGVCHDMLYNQAAKFRYMFGGKAKAPMVVRGMIGAGFSAAAQHSQSPYNVFAAVPGLKVVVPSSPYDVKGLLIQAIRDDDPVVFCEHKMLYDIKGEVPDAAYTIPFGVANYTREGTDVTIIALGLMVHRANEVADKLAKDGISVEVVDPRTISPLDEEGILESVASTGRVVIVDESAARCGFGHDVAALIAQKGFHYLKAPVELVTPPHTPVPFSPVLEKEWIPSVERIEQAVRKTLEA
>CP027254.2|AVN22048.1|1963727_1964690_-|thiamine-pyrophosphate-dependent-dehydrogenase-E1-component-subunit-alpha
MQLTEEQLLAAYKRMRDIREFEDRLHEENTNGDIPGFIHLYSGEEAVAVGICENLTDKDYITSTHRGHGHCIAKGCDIHAMMLEIFGKDDGLCRGKGGSMHIADLDKGMLGANGIVGGGPPLAIGAALTAKTLKTGGVGLSFTGDGGSNQGLTFEAMNMAVVLKLPVIFVFENNGFGEGTGHDYAVGSKDIAGRAAGFGLPAVKVDGTDFFAVYEAAQTAIERARRGEGPSVIETITNRFYGHFEGDPGLIRSKEEVEFIKENKDPLKIFREKVKGKIDEAKLDEIDAASKANVDDAVAKARAAAYPKPEQLLTDVYVSY
>CP027254.2|AVN22049.1|1965052_1966039_+|lipoyl-synthase
MDLKRQIETGIKLRGADKVARIPIKILPTEELPTKPDWIRAKITDFEEINRIKNLLRQQKLHSVCEEAACPNLPECFGGGTATFMIMGDICTRRCPFCDVAHGRPKPLDEDEPKHLAETVKNLNLKYVVITSVDRDDLHDGGAAHFVKCIEEIRKRCPETLIEILVPDFRGRLETALSTLSLSPPDVFNHNIETVPRLYKAMRPGSDYQHSLELLKRFKAYCPDIKTKSGLMVGLGEIEAEVLALLNDLKDYQVDLVTIGQYLQPSKSHAPIHRFVNLQEFERYTRHGKRLGFKNIWSGPMVRSSYFADRQYFGEEVPKPFSRQDVLS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP027254_1	1.2\|99410\|29\|CP027254\|PILER-CR	99410-99438	29	NZ_CP017657	Acinetobacter baumannii strain KAB08 plasmid unnamed, complete sequence	43957-43985	0	1.0
CP027254_1	1.2\|99410\|29\|CP027254\|PILER-CR	99410-99438	29	NZ_CP017649	Acinetobacter baumannii strain KAB04 plasmid unnamed, complete sequence	46020-46048	0	1.0
CP027254_1	1.2\|99410\|29\|CP027254\|PILER-CR	99410-99438	29	NZ_CP050915	Acinetobacter baumannii strain DT-Ab007 plasmid unnamed1, complete sequence	10075-10103	0	1.0
CP027254_1	1.2\|99410\|29\|CP027254\|PILER-CR	99410-99438	29	NZ_CP020580	Acinetobacter baumannii strain SSMA17 plasmid pSSMA17_1, complete sequence	67780-67808	0	1.0
CP027254_1	1.2\|99410\|29\|CP027254\|PILER-CR	99410-99438	29	NZ_CP020582	Acinetobacter baumannii strain JBA13 plasmid pJBA13_1, complete sequence	28630-28658	0	1.0
CP027254_1	1.1\|99349\|36\|CP027254\|PILER-CR	99349-99384	36	NZ_CP020580	Acinetobacter baumannii strain SSMA17 plasmid pSSMA17_1, complete sequence	67830-67865	6	0.833
CP027254_1	1.1\|99349\|36\|CP027254\|PILER-CR	99349-99384	36	NZ_CP020582	Acinetobacter baumannii strain JBA13 plasmid pJBA13_1, complete sequence	28680-28715	6	0.833
CP027254_1	1.1\|99349\|36\|CP027254\|PILER-CR	99349-99384	36	NZ_CP017657	Acinetobacter baumannii strain KAB08 plasmid unnamed, complete sequence	43900-43935	6	0.833
CP027254_1	1.1\|99349\|36\|CP027254\|PILER-CR	99349-99384	36	NZ_CP017649	Acinetobacter baumannii strain KAB04 plasmid unnamed, complete sequence	45963-45998	6	0.833
CP027254_1	1.1\|99349\|36\|CP027254\|PILER-CR	99349-99384	36	NZ_CP050915	Acinetobacter baumannii strain DT-Ab007 plasmid unnamed1, complete sequence	10018-10053	6	0.833
CP027254_1	1.1\|99349\|36\|CP027254\|PILER-CR	99349-99384	36	NC_019218	Uncultured bacterium HHV35 plasmid pHHV35, complete sequence	20683-20718	10	0.722
CP027254_1	1.1\|99349\|36\|CP027254\|PILER-CR	99349-99384	36	NZ_CP045351	Vibrio sp. THAF100 plasmid pTHAF100_a, complete sequence	795069-795104	11	0.694

1. spacer 1.2|99410|29|CP027254|PILER-CR matches to NZ_CP017657 (Acinetobacter baumannii strain KAB08 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

ctttttggtttagagtatccaagatggaa	CRISPR spacer
ctttttggtttagagtatccaagatggaa	Protospacer
*****************************

2. spacer 1.2|99410|29|CP027254|PILER-CR matches to NZ_CP017649 (Acinetobacter baumannii strain KAB04 plasmid unnamed, complete sequence) position: , mismatch: 0, identity: 1.0

ctttttggtttagagtatccaagatggaa	CRISPR spacer
ctttttggtttagagtatccaagatggaa	Protospacer
*****************************

3. spacer 1.2|99410|29|CP027254|PILER-CR matches to NZ_CP050915 (Acinetobacter baumannii strain DT-Ab007 plasmid unnamed1, complete sequence) position: , mismatch: 0, identity: 1.0

ctttttggtttagagtatccaagatggaa	CRISPR spacer
ctttttggtttagagtatccaagatggaa	Protospacer
*****************************

4. spacer 1.2|99410|29|CP027254|PILER-CR matches to NZ_CP020580 (Acinetobacter baumannii strain SSMA17 plasmid pSSMA17_1, complete sequence) position: , mismatch: 0, identity: 1.0

ctttttggtttagagtatccaagatggaa	CRISPR spacer
ctttttggtttagagtatccaagatggaa	Protospacer
*****************************

5. spacer 1.2|99410|29|CP027254|PILER-CR matches to NZ_CP020582 (Acinetobacter baumannii strain JBA13 plasmid pJBA13_1, complete sequence) position: , mismatch: 0, identity: 1.0

ctttttggtttagagtatccaagatggaa	CRISPR spacer
ctttttggtttagagtatccaagatggaa	Protospacer
*****************************

6. spacer 1.1|99349|36|CP027254|PILER-CR matches to NZ_CP020580 (Acinetobacter baumannii strain SSMA17 plasmid pSSMA17_1, complete sequence) position: , mismatch: 6, identity: 0.833

gatttttcgtaagttattgatatttatttcatcata	CRISPR spacer
acctcttcataagttattgatatttctttcatcata	Protospacer
. .*.***.**************** **********

7. spacer 1.1|99349|36|CP027254|PILER-CR matches to NZ_CP020582 (Acinetobacter baumannii strain JBA13 plasmid pJBA13_1, complete sequence) position: , mismatch: 6, identity: 0.833

gatttttcgtaagttattgatatttatttcatcata	CRISPR spacer
acctcttcataagttattgatatttctttcatcata	Protospacer
. .*.***.**************** **********

8. spacer 1.1|99349|36|CP027254|PILER-CR matches to NZ_CP017657 (Acinetobacter baumannii strain KAB08 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.833

gatttttcgtaagttattgatatttatttcatcata	CRISPR spacer
acctcttcataagttattgatatttctttcatcata	Protospacer
. .*.***.**************** **********

9. spacer 1.1|99349|36|CP027254|PILER-CR matches to NZ_CP017649 (Acinetobacter baumannii strain KAB04 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.833

gatttttcgtaagttattgatatttatttcatcata	CRISPR spacer
acctcttcataagttattgatatttctttcatcata	Protospacer
. .*.***.**************** **********

10. spacer 1.1|99349|36|CP027254|PILER-CR matches to NZ_CP050915 (Acinetobacter baumannii strain DT-Ab007 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.833

gatttttcgtaagttattgatatttatttcatcata	CRISPR spacer
acctcttcataagttattgatatttctttcatcata	Protospacer
. .*.***.**************** **********

11. spacer 1.1|99349|36|CP027254|PILER-CR matches to NC_019218 (Uncultured bacterium HHV35 plasmid pHHV35, complete sequence) position: , mismatch: 10, identity: 0.722

gatttttcgtaagttattgatatttatttcatcata	CRISPR spacer
gtcgcatcgtaagttattgatatttatataatagtt	Protospacer
* . . ********************* * ** .*

12. spacer 1.1|99349|36|CP027254|PILER-CR matches to NZ_CP045351 (Vibrio sp. THAF100 plasmid pTHAF100_a, complete sequence) position: , mismatch: 11, identity: 0.694

gatttttcgtaagttattgatatttatttcatcata	CRISPR spacer
aaaccaatctaagttattaatatttttttcatcatc	Protospacer
.* ..  . *********.****** *********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

79406 : 118571

Catovirus(20.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVN20467.1\|79406_80432_+\|transposase	IS30-like element ISAba125 family transposase	NA	NA	NA	NA
AVN20468.1\|81663_82416_+	histidine utilization repressor	NA	NA	NA	NA
AVN23690.1\|82448_82988_+	hypothetical protein	NA	NA	NA	NA
AVN20469.1\|83248_84916_+	urocanate hydratase	NA	NA	NA	NA
AVN20470.1\|85003_86542_+	histidine ammonia-lyase	A0A1V0S940	Catovirus	1.9e-88	38.2
AVN20471.1\|86606_88019_+	amino acid permease	NA	NA	NA	NA
AVN20472.1\|88070_89276_+	imidazolonepropionase	NA	NA	NA	NA
AVN20473.1\|89286_90207_+	formimidoylglutamase	NA	NA	NA	NA
AVN20474.1\|91648_92134_-	N-acetyltransferase	NA	NA	NA	NA
AVN20475.1\|92130_94095_-	carbamoyltransferase	E3SL71	Synechococcus_phage	1.6e-36	31.0
AVN20476.1\|94739_95765_-\|transposase	IS30 family transposase	NA	NA	NA	NA
AVN20477.1\|95891_96119_-	hypothetical protein	NA	NA	NA	NA
AVN20478.1\|96490_97516_+\|transposase	IS30 family transposase	NA	NA	NA	NA
AVN20479.1\|98802_99087_+	hypothetical protein	NA	NA	NA	NA
AVN20480.1\|99485_102203_-	DEAD/DEAH box helicase	A0A2H4J643	uncultured_Caudovirales_phage	9.8e-16	22.9
AVN20481.1\|102206_105053_-	DUF1156 domain-containing protein	NA	NA	NA	NA
AVN20482.1\|105052_105640_-	DUF3780 domain-containing protein	A0A1P8DTE9	Proteus_phage	4.5e-27	42.3
AVN20483.1\|105636_108705_-	DUF499 domain-containing protein	NA	NA	NA	NA
AVN20484.1\|108910_109993_-	ImmA/IrrE family metallo-endopeptidase	A0A0A7RTT7	Clostridium_phage	2.2e-27	26.0
AVN20485.1\|110029_110641_-	hypothetical protein	NA	NA	NA	NA
AVN20486.1\|110858_112427_-	hypothetical protein	NA	NA	NA	NA
AVN20487.1\|112426_113944_-\|transposase	transposase	NA	NA	NA	NA
AVN20488.1\|113944_115612_-	transcriptional antiterminator	NA	NA	NA	NA
AVN20489.1\|115639_117781_-\|transposase	transposase	NA	NA	NA	NA
AVN20490.1\|117764_118571_-\|transposase	heteromeric transposase endonuclease subunit TnsA	NA	NA	NA	NA

DBSCAN-SWA_2

2372972 : 2491087

120

Acinetobacter_phage(67.69%)

transposase,integrase,terminase,head,plate,tail,tRNA,capsid

attL 2436598:2436654|attR 2486987:2487043

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVN22415.1\|2372972_2375204_-\|plate	type VI secretion system baseplate subunit TssK	NA	NA	NA	NA
AVN22416.1\|2375206_2375860_-	DUF1989 domain-containing protein	NA	NA	NA	NA
AVN22417.1\|2375875_2376616_-	DUF1989 domain-containing protein	NA	NA	NA	NA
AVN22418.1\|2376927_2378091_-	glutathione-dependent formaldehyde dehydrogenase	E3SJ82	Synechococcus_phage	1.8e-11	26.7
AVN22419.1\|2378329_2379280_-	3-hydroxyacyl-CoA dehydrogenase	NA	NA	NA	NA
AVN22420.1\|2379483_2380416_+	drug/metabolite DMT transporter permease	NA	NA	NA	NA
AVN22421.1\|2380544_2380976_+	SRPBCC family protein	NA	NA	NA	NA
AVN22422.1\|2381026_2381593_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
AVN22423.1\|2382381_2382897_-	SMI1/KNR4 family protein	NA	NA	NA	NA
AVN22424.1\|2383165_2384566_-	hypothetical protein	NA	NA	NA	NA
AVN22425.1\|2384577_2390649_-	filamentous hemagglutinin N-terminal domain-containing protein	A0A0R6PJK4	Moraxella_phage	3.4e-125	30.6
AVN22426.1\|2391777_2392803_-\|transposase	IS30 family transposase	NA	NA	NA	NA
AVN22427.1\|2393867_2395088_-	voltage-gated chloride channel protein	A0A1X9I5Z9	Streptococcus_phage	8.8e-33	29.7
AVN22428.1\|2395391_2397110_-	ATP-grasp domain-containing protein	NA	NA	NA	NA
AVN22429.1\|2397106_2398693_-	allophanate hydrolase	NA	NA	NA	NA
AVN22430.1\|2398725_2399541_-	putative hydro-lyase	NA	NA	NA	NA
AVN22431.1\|2399543_2400308_-	LamB/YcsF family protein	NA	NA	NA	NA
AVN22432.1\|2400342_2401596_-	divalent metal cation transporter	NA	NA	NA	NA
AVN22433.1\|2401941_2402853_-	LysR family transcriptional regulator	NA	NA	NA	NA
AVN22434.1\|2402944_2403148_-	zf-HC2 domain-containing protein	NA	NA	NA	NA
AVN22435.1\|2403117_2403738_-	RNA polymerase subunit sigma	NA	NA	NA	NA
AVN22436.1\|2403740_2404493_-	DUF2063 domain-containing protein	NA	NA	NA	NA
AVN22437.1\|2404446_2405307_-	DUF692 domain-containing protein	NA	NA	NA	NA
AVN22438.1\|2405376_2405685_-	hypothetical protein	NA	NA	NA	NA
AVN22439.1\|2405849_2406452_+	DoxX family protein	NA	NA	NA	NA
AVN22440.1\|2407643_2407988_-	hypothetical protein	A0A0P0HSF5	Acinetobacter_phage	1.7e-10	36.8
AVN22441.1\|2408299_2408758_-	hypothetical protein	A0A0P0HSF5	Acinetobacter_phage	1.4e-31	47.0
AVN22442.1\|2409008_2409203_-	hypothetical protein	NA	NA	NA	NA
AVN23839.1\|2409377_2409686_-	hypothetical protein	NA	NA	NA	NA
AVN22443.1\|2409855_2410062_-	hypothetical protein	NA	NA	NA	NA
AVN22444.1\|2410064_2410997_-\|transposase	IS5/IS1182 family transposase	Q1MVF0	Enterobacteria_phage	6.7e-57	41.4
AVN22445.1\|2411214_2412630_-	ethanolamine permease	NA	NA	NA	NA
AVN22446.1\|2412811_2413813_+	serine kinase	NA	NA	NA	NA
AVN22447.1\|2413887_2415213_+	phosphoserine phosphatase	NA	NA	NA	NA
AVN23840.1\|2415521_2416556_+	AraC family transcriptional regulator	NA	NA	NA	NA
AVN22448.1\|2416705_2418046_-	aspartate aminotransferase family protein	NA	NA	NA	NA
AVN22449.1\|2418449_2421089_+	DNA mismatch repair protein MutS	A0A1V0SC35	Catovirus	2.9e-33	25.2
AVN22450.1\|2421150_2421681_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
AVN22451.1\|2422026_2422350_+	ferredoxin family protein	NA	NA	NA	NA
AVN22452.1\|2422532_2423204_+	peptidase M15	NA	NA	NA	NA
AVN22453.1\|2423343_2424012_+	O-methyltransferase	W8CYT3	Bacillus_phage	5.7e-26	44.0
AVN22454.1\|2424128_2424971_-	universal stress protein	A0A2H4J154	uncultured_Caudovirales_phage	3.4e-36	33.9
AVN22455.1\|2425126_2425738_-	chloramphenicol acetyltransferase CAT	M1HKK6	Paramecium_bursaria_Chlorella_virus	7.3e-12	55.6
AVN22456.1\|2425730_2426330_-	DUF1949 domain-containing protein	A0A1X9I5T8	Streptococcus_phage	2.2e-21	33.9
AVN22457.1\|2426421_2427618_-	secretion protein HlyD	NA	NA	NA	NA
AVN22458.1\|2427614_2429756_-	type I secretion system permease/ATPase	W8CYL7	Bacillus_phage	1.4e-28	24.9
AVN23841.1\|2429752_2430976_-	RND transporter	NA	NA	NA	NA
AVN22459.1\|2431492_2432236_-	LPS export ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.8e-20	28.2
AVN22460.1\|2432235_2432784_-	lipopolysaccharide transport periplasmic protein LptA	NA	NA	NA	NA
AVN22461.1\|2432767_2433316_-	LPS export ABC transporter periplasmic protein LptC	NA	NA	NA	NA
AVN22462.1\|2433353_2433893_-	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	NA	NA	NA	NA
AVN22463.1\|2433896_2434874_-	KpsF/GutQ family sugar-phosphate isomerase	A0A2P0VNK5	Tetraselmis_virus	7.3e-38	31.7
AVN22464.1\|2435087_2436509_+\|tRNA	cysteine--tRNA ligase	M1PG92	Moumouvirus	2.5e-55	31.1
2436598:2436654	attL	NA	NA	NA	NA
AVN22465.1\|2436862_2437876_+\|integrase	site-specific integrase	A0A0R6PHH4	Moraxella_phage	2.9e-66	40.3
AVN22466.1\|2437904_2438102_-	hypothetical protein	A0A0D4DBH0	Acinetobacter_phage	6.8e-12	71.1
AVN22467.1\|2438238_2438781_-	hypothetical protein	A0A0B5L5G7	Acinetobacter_phage	4.3e-88	84.4
AVN22468.1\|2438823_2439213_-	hypothetical protein	A0A0D4DBQ9	Acinetobacter_phage	2.7e-60	88.4
AVN22469.1\|2439272_2439815_-	DUF4376 domain-containing protein	A0A172Q0F8	Acinetobacter_phage	4.8e-31	45.3
AVN22470.1\|2449682_2450351_-\|tail	tail assembly protein	A0A0R6PIW1	Moraxella_phage	4.8e-41	47.5
AVN22471.1\|2450334_2451090_-\|tail	phage tail protein	A0A0R6PIM4	Moraxella_phage	1.0e-84	55.8
AVN22472.1\|2451096_2451795_-\|tail	phage minor tail protein L	A0A0R6PIG8	Moraxella_phage	5.3e-91	68.5
AVN22473.1\|2451804_2452161_-	hypothetical protein	NA	NA	NA	NA
AVN22474.1\|2452217_2452559_-\|tail	phage tail protein	NA	NA	NA	NA
AVN22475.1\|2452667_2452952_-	hypothetical protein	NA	NA	NA	NA
AVN22476.1\|2453014_2457001_-	replication protein	A0A0D4DC37	Acinetobacter_phage	9.2e-164	44.9
AVN22477.1\|2457097_2457616_-	DUF4468 domain-containing protein	A0A0P0I8L3	Acinetobacter_phage	7.6e-26	41.5
AVN22478.1\|2457711_2458116_-	type II toxin-antitoxin system HicB family antitoxin	A0A0D4DCG1	Acinetobacter_phage	1.7e-57	82.1
AVN22479.1\|2458205_2458388_-	type II toxin-antitoxin system HicA family toxin	A0A0D4DC32	Acinetobacter_phage	6.9e-27	91.7
AVN22480.1\|2458456_2458717_-	hypothetical protein	A0A1B1P9F7	Acinetobacter_phage	6.7e-23	63.6
AVN22481.1\|2458719_2459253_-	hypothetical protein	A0A0N7IRG3	Acinetobacter_phage	2.8e-44	61.2
AVN22482.1\|2459298_2460228_-	hypothetical protein	A0A059VG08	Pseudomonas_phage	6.9e-54	41.0
AVN22483.1\|2460335_2460554_-	hypothetical protein	A0A0P0I8C2	Acinetobacter_phage	2.0e-25	79.2
AVN22484.1\|2460555_2460954_-	hypothetical protein	A0A0D4DBX3	Acinetobacter_phage	3.0e-59	81.1
AVN22485.1\|2460955_2461324_-	hypothetical protein	A0A0D4DBN1	Acinetobacter_phage	7.2e-55	85.2
AVN22486.1\|2461295_2461700_-	hypothetical protein	A0A0P0IKR8	Acinetobacter_phage	2.4e-64	89.5
AVN22487.1\|2461880_2462249_-	glutamate 5-kinase	A0A0P0I456	Acinetobacter_phage	1.5e-52	80.3
AVN22488.1\|2462252_2462642_-	hypothetical protein	A0A0D4DC24	Acinetobacter_phage	1.4e-64	96.1
AVN22489.1\|2462646_2463312_-	stress-responsive nuclear envelope protein	J7I4P7	Acinetobacter_phage	2.7e-52	52.9
AVN22490.1\|2463375_2464332_-\|capsid	phage capsid protein	A0A0D4DBM4	Acinetobacter_phage	1.3e-167	93.1
AVN22491.1\|2464359_2465127_-	hypothetical protein	J7I0W4	Acinetobacter_phage	6.9e-108	80.8
AVN22492.1\|2465240_2465564_-	hypothetical protein	W8VYP4	Pseudomonas_phage	5.4e-22	52.0
AVN22493.1\|2465601_2466114_-	hypothetical protein	NA	NA	NA	NA
AVN22494.1\|2466305_2467409_-\|head	phage head morphogenesis protein	A0A0D4DBL9	Acinetobacter_phage	1.6e-182	85.8
AVN22495.1\|2467410_2468862_-	hypothetical protein	A0A0D4DCP1	Acinetobacter_phage	2.6e-257	89.6
AVN22496.1\|2468858_2470286_-\|terminase	terminase	A0A0D4DCE6	Acinetobacter_phage	7.2e-252	89.9
AVN22497.1\|2470275_2470746_-	DUF2280 domain-containing protein	A0A0D4DC15	Acinetobacter_phage	1.5e-68	79.5
AVN22498.1\|2470804_2471446_-	hypothetical protein	J7I4N9	Acinetobacter_phage	2.3e-104	82.2
AVN22499.1\|2471405_2471876_-	hypothetical protein	A0A0P0IRI6	Acinetobacter_phage	1.3e-48	63.2
AVN22500.1\|2472308_2472581_-	hypothetical protein	NA	NA	NA	NA
AVN22501.1\|2472579_2472822_+	hypothetical protein	NA	NA	NA	NA
AVN22502.1\|2473082_2473649_-	hypothetical protein	A0A1B1P9I8	Acinetobacter_phage	1.4e-46	52.0
AVN22503.1\|2473671_2473956_-	hypothetical protein	NA	NA	NA	NA
AVN22504.1\|2473965_2474373_-	DUF1064 domain-containing protein	A0A0R6PIZ9	Moraxella_phage	9.8e-21	48.2
AVN22505.1\|2474369_2474483_-	putative phage replication protein	A0A0P0IR92	Acinetobacter_phage	8.1e-10	86.5
AVN22506.1\|2474479_2475229_-	hypothetical protein	A0A0N7IRF0	Acinetobacter_phage	1.1e-134	96.8
AVN22507.1\|2475221_2476172_-	DUF1376 domain-containing protein	A0A0P0I481	Acinetobacter_phage	3.2e-99	63.6
AVN22508.1\|2476168_2477953_-	multidrug DMT transporter	Q5QF27	Pseudomonas_virus	1.8e-151	46.1
AVN22509.1\|2477949_2478243_-	hypothetical protein	NA	NA	NA	NA
AVN22510.1\|2478239_2478512_-	hypothetical protein	A0A0D4DCC3	Acinetobacter_phage	1.8e-39	97.8
AVN22511.1\|2478559_2478826_-	hypothetical protein	A0A0D4DBY7	Acinetobacter_phage	1.6e-43	100.0
AVN22512.1\|2478862_2479093_-	hypothetical protein	A0A0D4DBS7	Acinetobacter_phage	6.1e-36	100.0
AVN22513.1\|2479219_2479945_+	helix-turn-helix transcriptional regulator	A0A0D4DBI5	Acinetobacter_phage	1.8e-134	100.0
AVN22514.1\|2479984_2480284_+	hypothetical protein	A0A0D4DCL0	Acinetobacter_phage	1.5e-47	100.0
AVN22515.1\|2480323_2480614_+	hypothetical protein	A0A0D4DCB9	Acinetobacter_phage	7.9e-49	100.0
AVN22516.1\|2480671_2480887_+	KTSC domain-containing protein	A0A0D4DBY2	Acinetobacter_phage	5.0e-32	100.0
AVN22517.1\|2480937_2481228_+	hypothetical protein	A0A0D4DBS2	Acinetobacter_phage	1.5e-44	100.0
AVN22518.1\|2481719_2482163_+	hypothetical protein	A0A0N7IRF7	Acinetobacter_phage	3.2e-73	95.9
AVN22519.1\|2482162_2482453_+	hypothetical protein	A0A0P0IDU2	Acinetobacter_phage	1.6e-49	99.0
AVN22520.1\|2482445_2482769_+	hypothetical protein	A0A0D4DCB5	Acinetobacter_phage	2.2e-55	95.3
AVN22521.1\|2482780_2483548_+	hypothetical protein	NA	NA	NA	NA
AVN22522.1\|2483562_2484525_+	hypothetical protein	A0A0D4DBR8	Acinetobacter_phage	1.3e-151	85.9
AVN22523.1\|2484526_2484772_+	hypothetical protein	A0A0P0IVN4	Acinetobacter_phage	1.6e-39	97.5
AVN22524.1\|2484774_2485254_+	hypothetical protein	NA	NA	NA	NA
AVN22525.1\|2485250_2485598_+	hypothetical protein	NA	NA	NA	NA
AVN22526.1\|2485594_2485798_+	hypothetical protein	NA	NA	NA	NA
AVN22527.1\|2485902_2486199_+	hypothetical protein	NA	NA	NA	NA
AVN22528.1\|2486222_2486852_-	hypothetical protein	NA	NA	NA	NA
AVN22529.1\|2487570_2488842_+	hypothetical protein	NA	NA	NA	NA
2486987:2487043	attR	NA	NA	NA	NA
AVN22530.1\|2488768_2489794_-\|transposase	IS30-like element ISAba125 family transposase	NA	NA	NA	NA
AVN22531.1\|2490061_2491087_+\|transposase	IS30-like element ISAba125 family transposase	NA	NA	NA	NA

DBSCAN-SWA_3

2509876 : 2517254

Acinetobacter_phage(50.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVN22553.1\|2509876_2510092_-	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	5.9e-17	61.7
AVN22554.1\|2510435_2511368_-	lauroyl acyltransferase	A0A1W6JP29	Morganella_phage	2.7e-42	34.7
AVN22555.1\|2511607_2512225_+	LysE family translocator	NA	NA	NA	NA
AVN22556.1\|2512321_2512867_-	hypothetical protein	A0A0N7IRE7	Acinetobacter_phage	5.6e-72	70.7
AVN22557.1\|2512897_2513287_-	hypothetical protein	A0A0P0IYC0	Acinetobacter_phage	3.0e-51	76.7
AVN22558.1\|2513496_2513751_-	hypothetical protein	NA	NA	NA	NA
AVN22559.1\|2514423_2515095_+	helix-turn-helix domain-containing protein	A0A1B1P9J5	Acinetobacter_phage	9.1e-64	55.8
AVN22560.1\|2515247_2515481_-\|transposase	transposase	NA	NA	NA	NA
AVN22561.1\|2515988_2517254_+	exodeoxyribonuclease VII large subunit	M1NLU2	Moumouvirus	8.1e-13	29.5

DBSCAN-SWA_4

2554975 : 2607433

Acinetobacter_phage(62.86%)

transposase,terminase,head,tRNA,coat

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVN22597.1\|2554975_2555692_+\|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
AVN22598.1\|2555864_2556491_+	glutathione S-transferase	NA	NA	NA	NA
AVN22599.1\|2556504_2557284_-	DUF2520 domain-containing protein	NA	NA	NA	NA
AVN22600.1\|2557377_2558799_-	OmpA family protein	NA	NA	NA	NA
AVN22601.1\|2559012_2560257_-	aspartate carbamoyltransferase	NA	NA	NA	NA
AVN22602.1\|2560260_2561277_-	aspartate carbamoyltransferase catalytic subunit	NA	NA	NA	NA
AVN22603.1\|2561401_2561746_-	hypothetical protein	NA	NA	NA	NA
AVN22604.1\|2561964_2564196_+	bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL	NA	NA	NA	NA
AVN22605.1\|2564302_2565328_-\|transposase	IS30-like element ISAba125 family transposase	NA	NA	NA	NA
AVN22606.1\|2565340_2565721_-	hypothetical protein	NA	NA	NA	NA
AVN22607.1\|2565989_2566484_+	damage-inducible protein CinA	A0A218MNG4	uncultured_virus	4.5e-28	42.7
AVN22608.1\|2566534_2569114_-	ATP-dependent chaperone ClpB	K4FB40	Cronobacter_phage	1.3e-123	32.7
AVN22609.1\|2569414_2570224_+	M23 family peptidase	A8ATH6	Listeria_phage	2.3e-13	36.6
AVN23844.1\|2570220_2570646_-	N-acetyltransferase	NA	NA	NA	NA
AVN22610.1\|2570742_2571165_-	OsmC family protein	NA	NA	NA	NA
AVN23845.1\|2571243_2571363_-	hypothetical protein	NA	NA	NA	NA
AVN22611.1\|2571603_2572311_+	cAMP-activated global transcriptional regulator CRP	NA	NA	NA	NA
AVN22612.1\|2572470_2573520_+	NADP(H)-dependent aldo-keto reductase	NA	NA	NA	NA
AVN22613.1\|2573574_2574354_-	M48 family peptidase	NA	NA	NA	NA
AVN22614.1\|2574469_2574787_-	hypothetical protein	NA	NA	NA	NA
AVN22615.1\|2574909_2576229_-	adenylosuccinate synthase	A0A2P1EKE7	Megavirus	3.7e-69	36.2
AVN22616.1\|2576292_2577459_-	ATP phosphoribosyltransferase regulatory subunit	NA	NA	NA	NA
AVN22617.1\|2577770_2578790_-	aldehyde dehydrogenase	NA	NA	NA	NA
AVN22618.1\|2579059_2581696_+\|tRNA	alanine--tRNA ligase	A0A1V0SK38	Klosneuvirus	3.7e-76	38.4
AVN22619.1\|2581982_2583188_+	DUF4102 domain-containing protein	A0A0R6PHZ3	Moraxella_phage	7.2e-104	50.5
AVN22620.1\|2583349_2583844_+	DNA polymerase V	A0A2H4J538	uncultured_Caudovirales_phage	4.8e-46	61.5
AVN22621.1\|2583847_2585146_+	DNA polymerase V subunit UmuC	A0A2H4JBL5	uncultured_Caudovirales_phage	1.5e-155	60.8
AVN22622.1\|2585223_2585970_+\|transposase	IS5/IS1182 family transposase	A0A0N9SHJ4	Paenibacillus_phage	1.8e-12	33.3
AVN22623.1\|2586107_2587271_-	glutathione-dependent formaldehyde dehydrogenase	A0A0K0KVL7	Prochlorococcus_phage	5.5e-08	26.5
AVN22624.1\|2587712_2588129_+	hypothetical protein	NA	NA	NA	NA
AVN22625.1\|2589012_2589207_+\|transposase	IS30 family transposase	NA	NA	NA	NA
AVN22626.1\|2589555_2589819_-	hypothetical protein	NA	NA	NA	NA
AVN22627.1\|2589820_2590501_-	hypothetical protein	A0A0R6PJY5	Moraxella_phage	2.5e-53	49.3
AVN22628.1\|2590599_2591004_-	type II toxin-antitoxin system HicB family antitoxin	A0A0D4DCG1	Acinetobacter_phage	5.6e-69	99.3
AVN22629.1\|2591096_2591279_-	type II toxin-antitoxin system HicA family toxin	A0A0D4DC32	Acinetobacter_phage	7.4e-29	100.0
AVN23846.1\|2591604_2592120_-	hypothetical protein	A0A0N7IRG3	Acinetobacter_phage	2.8e-73	96.4
AVN22630.1\|2592190_2593108_-	hypothetical protein	A0A0P0IL42	Acinetobacter_phage	1.1e-165	97.4
AVN22631.1\|2593160_2594489_-	hypothetical protein	A0A0D4DCQ4	Acinetobacter_phage	1.2e-86	49.1
AVN22632.1\|2594488_2594842_-	hypothetical protein	A0A0P0IY61	Acinetobacter_phage	1.5e-57	94.0
AVN22633.1\|2594910_2595309_-	hypothetical protein	A0A0P0IRA6	Acinetobacter_phage	1.2e-68	94.7
AVN22634.1\|2595310_2595679_-	hypothetical protein	A0A0P0IDX0	Acinetobacter_phage	1.1e-55	98.1
AVN22635.1\|2595650_2596055_-	hypothetical protein	A0A0P0IKR8	Acinetobacter_phage	1.9e-61	88.1
AVN22636.1\|2596792_2597161_-	glutamate 5-kinase	A0A0P0I456	Acinetobacter_phage	7.2e-63	95.9
AVN22637.1\|2597160_2597541_-	hypothetical protein	A0A0P0IVQ3	Acinetobacter_phage	8.2e-54	84.9
AVN22638.1\|2597544_2598075_-	HeH/LEM domain protein	A0A0N7IRE4	Acinetobacter_phage	4.2e-40	91.7
AVN22639.1\|2598117_2599089_-\|coat	phage coat protein	A0A2H4JIE6	uncultured_Caudovirales_phage	4.4e-136	72.7
AVN22640.1\|2599091_2599823_-	hypothetical protein	A0A0P0J090	Acinetobacter_phage	1.0e-92	75.4
AVN22641.1\|2599931_2600483_-	hypothetical protein	A0A2I7RHW2	Vibrio_phage	6.2e-18	68.4
AVN22642.1\|2600772_2601015_-	hypothetical protein	A0A0P0IY55	Acinetobacter_phage	2.6e-37	93.8
AVN22643.1\|2601113_2601542_-	hypothetical protein	A0A0D4DBV9	Acinetobacter_phage	7.3e-67	92.3
AVN22644.1\|2601551_2602655_-\|head	phage head morphogenesis protein	A0A0P0IR98	Acinetobacter_phage	3.3e-180	85.2
AVN22645.1\|2602664_2604008_-	DUF4055 domain-containing protein	A0A0P0IDW1	Acinetobacter_phage	6.6e-231	89.1
AVN22646.1\|2604047_2605340_-\|terminase	terminase	A0A1B1P9C9	Acinetobacter_phage	4.9e-215	86.3
AVN22647.1\|2605299_2605815_-	DUF2280 domain-containing protein	A0A1B1P9C2	Acinetobacter_phage	3.2e-45	61.3
AVN22648.1\|2605873_2606515_-	hypothetical protein	J7I4N9	Acinetobacter_phage	2.2e-123	96.2
AVN22649.1\|2606483_2606918_-	hypothetical protein	A0A0P0IVP9	Acinetobacter_phage	1.4e-78	97.9
AVN22650.1\|2606977_2607433_-	hypothetical protein	A0A0P0HSF5	Acinetobacter_phage	3.5e-83	98.7

DBSCAN-SWA_5

2611391 : 2619781

Acinetobacter_phage(44.44%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVN22656.1\|2611391_2611868_-	hypothetical protein	A0A2H4J548	uncultured_Caudovirales_phage	1.2e-25	40.3
AVN22657.1\|2611864_2612266_-	DUF559 domain-containing protein	A0A0P0I8E8	Acinetobacter_phage	8.1e-68	98.5
AVN22658.1\|2612411_2612660_+	DUF551 domain-containing protein	A0A0P0HSE1	Acinetobacter_phage	5.7e-40	96.1
AVN22659.1\|2612656_2612941_+	hypothetical protein	A0A0P0HSI5	Acinetobacter_phage	2.2e-43	94.7
AVN22660.1\|2612944_2613202_+	hypothetical protein	A0A0P0J0B1	Acinetobacter_phage	1.2e-40	88.1
AVN22661.1\|2613203_2613419_+	hypothetical protein	A0A0R6PG25	Moraxella_phage	3.7e-11	55.9
AVN22662.1\|2613628_2614909_+	aspartate kinase	NA	NA	NA	NA
AVN22663.1\|2615155_2615410_+	carbon storage regulator	A0A2I7RT00	Vibrio_phage	8.8e-12	66.7
AVN22664.1\|2615477_2616044_-	ribonuclease HII	E3T5H8	Cafeteria_roenbergensis_virus	2.4e-25	43.1
AVN23848.1\|2616114_2616555_-	hypothetical protein	NA	NA	NA	NA
AVN22665.1\|2616744_2617302_+	cytochrome b	NA	NA	NA	NA
AVN22666.1\|2617346_2618345_-	adenosine deaminase	NA	NA	NA	NA
AVN22667.1\|2618461_2619781_-	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	3.1e-60	36.0

DBSCAN-SWA_6

3215139 : 3223342

uncultured_Caudovirales_phage(71.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVN23162.1\|3215139_3216363_-	ImmA/IrrE family metallo-endopeptidase	A0A222YXG1	Escherichia_phage	4.1e-22	47.1
AVN23163.1\|3216352_3216625_-	hypothetical protein	NA	NA	NA	NA
AVN23164.1\|3217032_3217851_-	hypothetical protein	NA	NA	NA	NA
AVN23165.1\|3218147_3219215_-	NAD(P)/FAD-dependent oxidoreductase	A0A2H4J2Q2	uncultured_Caudovirales_phage	4.2e-95	59.5
AVN23166.1\|3219319_3220273_-	thioredoxin-disulfide reductase	A0A2I2L5E1	Orpheovirus	1.2e-61	42.8
AVN23167.1\|3220291_3220996_-	arsenical resistance protein ArsH	A0A2H4J5V6	uncultured_Caudovirales_phage	1.3e-92	72.5
AVN23168.1\|3221000_3222041_-	arsenical-resistance protein	NA	NA	NA	NA
AVN23169.1\|3222048_3222522_-	arsenate reductase ArsC	A0A2H4J8A6	uncultured_Caudovirales_phage	5.6e-36	51.3
AVN23170.1\|3222528_3222852_-	transcriptional regulator	A0A2H4J145	uncultured_Caudovirales_phage	1.2e-21	61.0
AVN23171.1\|3222907_3223342_-	arsenate reductase (glutaredoxin)	A0A2H4J8T1	uncultured_Caudovirales_phage	5.3e-41	62.0

DBSCAN-SWA_7

3762669 : 3773873

Enterobacteria_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVN23618.1\|3762669_3763806_-	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	A0A1V0SAG5	Catovirus	1.2e-31	32.2
AVN23619.1\|3763802_3765065_-	flippase	NA	NA	NA	NA
AVN23620.1\|3765108_3765675_-	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	6.5e-47	52.2
AVN23621.1\|3765732_3766626_-	glucose-1-phosphate thymidylyltransferase	A0A291LA53	Escherichia_phage	4.2e-109	65.9
AVN23622.1\|3766625_3767531_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	2.6e-29	32.2
AVN23623.1\|3767547_3768624_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	4.8e-99	53.1
AVN23624.1\|3768646_3769924_-	Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB	A0A218MKK1	uncultured_virus	4.9e-10	23.9
AVN23933.1\|3770128_3771229_+	hypothetical protein	NA	NA	NA	NA
AVN23625.1\|3771230_3771659_+	low molecular weight phosphotyrosine protein phosphatase	NA	NA	NA	NA
AVN23626.1\|3771680_3773873_+	tyrosine protein kinase	A0A1X9I5D6	Streptococcus_phage	1.5e-19	34.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP027251

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. CP027254

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection