CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP017429	Staphylococcus simulans strain MR3 plasmid unnamed5, complete sequence	0 crisprs	RT,csa3	0	0	2	0
CP017428	Staphylococcus simulans strain MR3 chromosome, complete genome	2 crisprs	csa3,cas9,cas1,cas2,WYL,DEDDh,cas3,DinG,RT	0	13	7	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

41551 : 81087

Staphylococcus_phage(63.64%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVO03360.1\|41551_42226_-\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	7.6e-127	98.2
AVO03361.1\|42677_43571_-	hypothetical protein	NA	NA	NA	NA
AVO03362.1\|44779_45019_+	hypothetical protein	NA	NA	NA	NA
AVO03363.1\|45140_45428_-	hypothetical protein	NA	NA	NA	NA
AVO03364.1\|47007_47949_+	hypothetical protein	NA	NA	NA	NA
AVO03365.1\|49536_49770_-	hypothetical protein	NA	NA	NA	NA
AVO03366.1\|51698_51830_+	hemolysin activation protein	NA	NA	NA	NA
AVO03367.1\|52507_52948_+	hypothetical protein	NA	NA	NA	NA
AVO03368.1\|52944_53403_+	hypothetical protein	NA	NA	NA	NA
AVO03369.1\|53591_54266_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.6e-124	96.9
AVO03370.1\|54479_55313_-	hypothetical protein	NA	NA	NA	NA
AVO03371.1\|55701_56151_-	hypothetical protein	NA	NA	NA	NA
AVO03372.1\|56153_56507_-	hypothetical protein	NA	NA	NA	NA
AVO03373.1\|56554_56752_-	hypothetical protein	NA	NA	NA	NA
AVO03374.1\|56836_57034_-	hypothetical protein	NA	NA	NA	NA
AVO03375.1\|57101_57776_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	2.4e-125	97.3
AVO03376.1\|58211_58511_+	hypothetical protein	NA	NA	NA	NA
AVO03377.1\|58513_58810_+	hypothetical protein	NA	NA	NA	NA
AVO03378.1\|58947_59133_-	transcriptional regulator	NA	NA	NA	NA
AVO03379.1\|59137_59476_-	hypothetical protein	NA	NA	NA	NA
AVO03380.1\|62011_62698_+	hypothetical protein	F2Y2R6	Organic_Lake_phycodnavirus	2.6e-10	32.2
AVO03381.1\|62710_63619_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.1e-43	41.6
AVO03382.1\|63619_64372_+	hypothetical protein	NA	NA	NA	NA
AVO03383.1\|64368_65106_+	hypothetical protein	NA	NA	NA	NA
AVO03384.1\|67095_67431_+	hypothetical protein	NA	NA	NA	NA
AVO03385.1\|67622_67928_-	hypothetical protein	NA	NA	NA	NA
AVO03463.1\|68575_69301_-	replication protein	NA	NA	NA	NA
AVO03386.1\|70187_70481_+	hypothetical protein	NA	NA	NA	NA
AVO03387.1\|70487_71114_+	hypothetical protein	NA	NA	NA	NA
AVO03464.1\|71175_71439_+	type II secretion protein	A0A1X9I6T6	Streptococcus_phage	1.1e-09	42.9
AVO03388.1\|73821_74028_-	hypothetical protein	NA	NA	NA	NA
AVO03389.1\|74124_74331_-	hypothetical protein	NA	NA	NA	NA
AVO03390.1\|74394_74673_+	hypothetical protein	NA	NA	NA	NA
AVO03391.1\|75010_75211_+	cold-shock protein	Q9AZD3	Lactococcus_phage	2.5e-17	61.9
AVO03392.1\|75341_76016_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	3.9e-123	95.1
AVO03393.1\|76160_77105_+	hypothetical protein	NA	NA	NA	NA
AVO03394.1\|77252_77927_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	7.1e-125	96.9
AVO03395.1\|79086_79572_-	lincosamide nucleotidyltransferase Lnu(A)	A0A2K5B286	Erysipelothrix_phage	2.8e-14	31.2
AVO03396.1\|80412_81087_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	7.1e-125	96.9

DBSCAN-SWA_2

95427 : 123379

Staphylococcus_phage(66.67%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVO03412.1\|95427_96102_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	7.1e-125	96.9
AVO03413.1\|96111_96957_-	replication protein	NA	NA	NA	NA
AVO03414.1\|97495_98041_-	hypothetical protein	NA	NA	NA	NA
AVO03415.1\|98805_99018_-	hypothetical protein	NA	NA	NA	NA
AVO03416.1\|99137_99281_-	Rep protein	NA	NA	NA	NA
AVO03417.1\|99312_99987_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	7.1e-125	96.9
AVO03418.1\|100021_100843_-	hypothetical protein	NA	NA	NA	NA
AVO03419.1\|101292_101859_+	hypothetical protein	NA	NA	NA	NA
AVO03420.1\|103009_103729_-	replication protein	NA	NA	NA	NA
AVO03421.1\|103931_104606_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.7e-126	98.2
AVO03422.1\|104880_105309_+	hypothetical protein	NA	NA	NA	NA
AVO03423.1\|105323_105704_+	hypothetical protein	NA	NA	NA	NA
AVO03424.1\|105845_107180_-\|transposase	transposase	A0A1X9I5T2	Streptococcus_phage	8.0e-112	47.2
AVO03425.1\|107307_107508_-	hypothetical protein	NA	NA	NA	NA
AVO03426.1\|107899_108574_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	1.6e-121	94.2
AVO03427.1\|108797_108998_-	cold-shock protein	Q9AZD3	Lactococcus_phage	2.5e-17	61.9
AVO03428.1\|111077_111461_-	hypothetical protein	A0A146ICT8	Staphylococcus_phage	1.7e-19	49.1
AVO03429.1\|111555_112230_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	6.6e-123	95.1
AVO03430.1\|112579_113137_+	hypothetical protein	A0A0N9SJ02	Staphylococcus_phage	4.3e-27	50.8
AVO03431.1\|113754_114363_+	transposon DNA-invertase	G8I4U3	Mycobacterium_phage	5.0e-13	30.2
AVO03432.1\|114545_114773_+	hypothetical protein	NA	NA	NA	NA
AVO03433.1\|115207_116911_-	ABC transporter	W8CYL7	Bacillus_phage	2.3e-79	35.9
AVO03434.1\|117560_120134_-	serine/threonine protein kinase	NA	NA	NA	NA
AVO03435.1\|120348_121005_-	hypothetical protein	NA	NA	NA	NA
AVO03436.1\|121195_121519_+	PadR family transcriptional regulator	NA	NA	NA	NA
AVO03437.1\|121511_122072_+	hypothetical protein	NA	NA	NA	NA
AVO03438.1\|122083_122680_+	hypothetical protein	NA	NA	NA	NA
AVO03439.1\|122746_123379_+\|transposase	IS6 family transposase	A0A0N9RU54	Staphylococcus_phage	9.3e-119	99.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. CP017428

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CRISPR-Cas detection and classification

Crispr_ID: CP017428_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP017428_1

504924-505551

TypeII

Consensus_repeat	Method
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	PILER-CR
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	CRISPRCasFinder
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	CRT

9 spacers

cas2,cas1,cas9

The CRISPR arrays of CP017428_1

>merge|CP017428|1|504924-505551|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCAACACCAGAAAATATCACGAAAGTAACAAGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCTTATGGCGTTTTGTGAAACAGTGCCGAATGGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCACATTATCGCAGTATGTTAGCTGACGAGCGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCGTGAGTGTACACAAAGATGAAGATGACATTGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCAATCATTCTAACGCCACACAGACACGCCCTGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCAATCATTCTAACGCCACACAGACACGCCCTGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCAAGTTCTTGCATTATGTTCAGAACATCATAGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCAAGTTCTTGCATTATGTTCAGAACATCATAGTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTCACTAACCCAAAAGGAACTTGAACTGCACCTGTTTTAGTACTCTGTAATTTTTAAGCAGCTTCGGCT

>CP017428|1|1|504924-505485|PILER-CR
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AACACCAGAAAATATCACGAAAGTAACAA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TTATGGCGTTTTGTGAAACAGTGCCGAATG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	ACATTATCGCAGTATGTTAGCTGACGAGC
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	GTGAGTGTACACAAAGATGAAGATGACATT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AATCATTCTAACGCCACACAGACACGCCCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AATCATTCTAACGCCACACAGACACGCCCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AAGTTCTTGCATTATGTTCAGAACATCATA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AAGTTCTTGCATTATGTTCAGAACATCATA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC

>CP017428|1|1|504924-505485|CRISPRCasFinder
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AACACCAGAAAATATCACGAAAGTAACAA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TTATGGCGTTTTGTGAAACAGTGCCGAATG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	ACATTATCGCAGTATGTTAGCTGACGAGC
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	GTGAGTGTACACAAAGATGAAGATGACATT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AATCATTCTAACGCCACACAGACACGCCCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AATCATTCTAACGCCACACAGACACGCCCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AAGTTCTTGCATTATGTTCAGAACATCATA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AAGTTCTTGCATTATGTTCAGAACATCATA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC

>CP017428|1|1|504924-505551|CRT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AACACCAGAAAATATCACGAAAGTAACAA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	TTATGGCGTTTTGTGAAACAGTGCCGAATG
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	ACATTATCGCAGTATGTTAGCTGACGAGC
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	GTGAGTGTACACAAAGATGAAGATGACATT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AATCATTCTAACGCCACACAGACACGCCCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AATCATTCTAACGCCACACAGACACGCCCT
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AAGTTCTTGCATTATGTTCAGAACATCATA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	AAGTTCTTGCATTATGTTCAGAACATCATA
GTTTTAGTACTCTGTAATTTTAGGTATAAGTGATTC	ACTAACCCAAAAGGAACTTGAACTGCACCT
GTTTTAGTACTCTGTAATTTTTAAGCAGCTTCGGCT

Protein	Signature genes	Signature genes Name	Protein_function
CP017428.1\|AVO03244.1\|500410_502660_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187774
CP017428.1\|AVO01245.1\|498804_499242_+\|hypothetical-protein	unknown	unknown	unknown
CP017428.1\|AVO01246.1\|502667_503573_+\|subtype-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
CP017428.1\|AVO01254.1\|512878_514108_+\|iron-transporter	unknown	unknown	gnl\|CDD\|224826
CP017428.1\|AVO01250.1\|509284_510292_+\|allophanate-hydrolase	unknown	unknown	gnl\|CDD\|224895
CP017428.1\|AVO01256.1\|515896_516076_-\|hypothetical-protein	unknown	unknown	unknown
CP017428.1\|AVO01251.1\|510294_510738_+\|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit	unknown	unknown	gnl\|CDD\|235777
CP017428.1\|AVO01244.1\|497114_498461_-\|sulfite-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|225723
CP017428.1\|AVO01247.1\|503584_503893_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
CP017428.1\|AVO01252.1\|510755_512120_+\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	unknown	unknown	gnl\|CDD\|236307
CP017428.1\|AVO01249.1\|508563_509295_+\|allophanate-hydrolase	unknown	unknown	gnl\|CDD\|224960
CP017428.1\|AVO01240.1\|491845_493267_+\|glucuronate-isomerase	unknown	unknown	gnl\|CDD\|235087
CP017428.1\|AVO01255.1\|514333_515830_+\|xylulokinase	unknown	unknown	gnl\|CDD\|198374
CP017428.1\|AVO01248.1\|503903_504893_+\|hypothetical-protein	unknown	unknown	unknown
CP017428.1\|AVO01241.1\|493263_494310_+\|mannonate-dehydratase	unknown	unknown	gnl\|CDD\|235172
CP017428.1\|AVO01253.1\|512116_512875_+\|lactam-utilization-protein-LamB	unknown	unknown	gnl\|CDD\|235446
CP017428.1\|AVO01243.1\|495177_496977_+\|beta-glucuronidase	unknown	unknown	gnl\|CDD\|236657
CP017428.1\|AVO01242.1\|494314_495157_+\|D-mannonate-oxidoreductase	unknown	unknown	gnl\|CDD\|236216
CP017428.1\|AVO03245.1\|505671_506745_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226167
CP017428.1\|AVO03246.1\|506999_508058_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226167

Protein	Function_ID	Function_description	E-value
CP017428.1\|AVO03244.1\|500410_502660_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|187774	cd09643, Csn1, CRISPR/Cas system-associated protein Cas9. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II.	9.32354e-74
CP017428.1\|AVO01254.1\|512878_514108_+\|iron-transporter	gnl\|CDD\|224826	COG1914, MntH, Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism].	2.39716e-80
CP017428.1\|AVO03245.1\|505671_506745_+\|hypothetical-protein	gnl\|CDD\|226167	COG3641, PfoR, Predicted membrane protein, putative toxin regulator [General function prediction only].	2.86836e-95
CP017428.1\|AVO01255.1\|514333_515830_+\|xylulokinase	gnl\|CDD\|198374	cd07808, FGGY_D-XK_EcXK-like, Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases. This subgroup is predominantly composed of bacterial D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17), which catalyze the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. D-xylulose has been used as a source of carbon and energy by a variety of microorganisms. Some uncharacterized sequences are also included in this subgroup. The prototypical member of this CD is Escherichia coli xylulokinase (EcXK), which exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ is required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	0
CP017428.1\|AVO01250.1\|509284_510292_+\|allophanate-hydrolase	gnl\|CDD\|224895	COG1984, DUR1, Allophanate hydrolase subunit 2 [Amino acid transport and metabolism].	2.84305e-121
CP017428.1\|AVO01251.1\|510294_510738_+\|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit	gnl\|CDD\|235777	PRK06302, PRK06302, acetyl-CoA carboxylase biotin carboxyl carrier protein.	8.12324e-35
CP017428.1\|AVO01244.1\|497114_498461_-\|sulfite-reductase-subunit-alpha	gnl\|CDD\|225723	COG3182, PiuB, Uncharacterized iron-regulated membrane protein [Function unknown].	7.82722e-100
CP017428.1\|AVO01247.1\|503584_503893_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.62482e-35
CP017428.1\|AVO01249.1\|508563_509295_+\|allophanate-hydrolase	gnl\|CDD\|224960	COG2049, DUR1, Allophanate hydrolase subunit 1 [Amino acid transport and metabolism].	2.0211e-92
CP017428.1\|AVO01240.1\|491845_493267_+\|glucuronate-isomerase	gnl\|CDD\|235087	PRK02925, PRK02925, glucuronate isomerase; Reviewed.	0
CP017428.1\|AVO01252.1\|510755_512120_+\|acetyl-CoA-carboxylase-biotin-carboxylase-subunit	gnl\|CDD\|236307	PRK08591, PRK08591, acetyl-CoA carboxylase biotin carboxylase subunit; Validated.	0
CP017428.1\|AVO01246.1\|502667_503573_+\|subtype-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	7.34483e-93
CP017428.1\|AVO01253.1\|512116_512875_+\|lactam-utilization-protein-LamB	gnl\|CDD\|235446	PRK05406, PRK05406, 5-oxoprolinase subunit PxpA.	5.91249e-154
CP017428.1\|AVO01241.1\|493263_494310_+\|mannonate-dehydratase	gnl\|CDD\|235172	PRK03906, PRK03906, mannonate dehydratase; Provisional.	0
CP017428.1\|AVO01243.1\|495177_496977_+\|beta-glucuronidase	gnl\|CDD\|236657	PRK10150, PRK10150, beta-D-glucuronidase; Provisional.	0
CP017428.1\|AVO01242.1\|494314_495157_+\|D-mannonate-oxidoreductase	gnl\|CDD\|236216	PRK08277, PRK08277, D-mannonate oxidoreductase; Provisional.	3.50236e-161
CP017428.1\|AVO03246.1\|506999_508058_+\|hypothetical-protein	gnl\|CDD\|226167	COG3641, PfoR, Predicted membrane protein, putative toxin regulator [General function prediction only].	2.30293e-87

>CP017428.1|AVO01248.1|503903_504893_+|hypothetical-protein
MYEAVLEISIEELPRVILNTSEYTSIYNEDSTHEEYILETLKNYFQPRNSNKDCVTITNLLECERVSNNRFRGFILNHSAIENEHQLAATSMMTKKIIRKLHNDMEIEGYINSVNVLLDDLRENLRGTLPLAVKSFDLKQFIRLLSFKYDYTEDYARLINRLEQVVPLVVDEMNYQAKEKAFLIYLYPEAGLSIKEQIRFRKTLNDLPIPIIVLTESSYFLSENIKGLNYFINNIQMITEEFIDDSYWNAPINIEIEKFKERFEYLFKKYCSFLEVNPTISNYNLTEIVVFDDLDLYIVIAFLKHCKFNYQLDIDREKISSALSVYLFS
>CP017428.1|AVO01247.1|503584_503893_+|CRISPR-associated-endonuclease-Cas2
MRVMIMFDLPTDTKEERRLYSKFRKGLISEGFLMMQYSIYIKSCINKDSAESSVNYVKRILPPDGHVRALTITEKQYEKMKILLGEEDKNIEILGDNRTILF
>CP017428.1|AVO01246.1|502667_503573_+|subtype-II-CRISPR-associated-endonuclease-Cas1
MAWRIVYLSEVDKLALNLNNLKIAKGDLEVKIPLSDIFAIVIEDLTTTITSRLMIELSKYNILVVFCNQQHLPECMVHPINGHFNQYGQMKEQLQWSEQNKGELWKHILVQKIQNQIQCMKHVGVLDERINKMKQLQTLVTSRDEMNIEGQAAKYYFNTFFEDFRRDDEFLIENMVLNFGYTILNSAIARTIVAKGLIPALGIHHIGARNHFNLASDIIEVFRPLVDLYLLKHPPEEEYMTKAYRLELVNLMHARVRIDGKQHTVIRAIEIMVQSIIEYFRTGRYETLKLPNIKQYSFYES
>CP017428.1|AVO03244.1|500410_502660_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MNEEDIKGYRVTSTGKPEFTNFKIYHDIKGITSRKEILDNADLLNQIAEILTIYQSAEDIQEELAELEPKLTQEEIEQISNLTGYTGTHRLSLKAINLILDELWHTSDNQMTIFNRLKLVPKKVDLSQQKEIPTSLVDDFILSPVVKRSFIQSIKVINAIIKKFGLPKDIIIELAREKNSKEVQKFINEMQKRNRQTNERIEKIIKETGKEKAKFLIEKIKLHDMQEGKCLYSLESIPLEDLLNNPYHYEVDHIIPRSVSFDNSFNNKVLVKQEENSKKGNRTPFQYLSSSDAKISYETFKKHILNLSKGKGRVSKKKKEYLLEERDINRFSVQKDFINRNLVDTRYATRELMNLLKSYFRVNDLDVKVKSINGGFTSFLRKKWKFKKERNQGYKHHAEDALVIANADFIFKEWKKLDTTNKVMENQTVEEQQAENMPGIETDDEYKEIFVIPRQIQSIKDFKDYKYSHRVDKKPNRELVNDTLYSTRKDDKGNTLIINNIKGLYDKDNDKLKNLIKKSPEKLLMYHHDPQTYQKLKTIMEQYSNEKNPLYKYHEETGNYLTKYSKKDNGPIIKKVKYYGKKLNAHLDITNDYSNSQNKIVKLSLKPYRFDVYLDNGAYKFVTVKNLDVIKKEGFFKIDSNAYEKAKSEKKIDGNAVFIASFYNNDLIKIDGELYRIIGVNNDSVNRVELNMIDITYKEFLENIDDKRTPRILKTISQKTYSIEKYSADILGNLYKVKSKKKPQMIMKG
>CP017428.1|AVO01245.1|498804_499242_+|hypothetical-protein
MRKIGIFLTTLVAVALIFTGIEDIVKGAEAQAAKAVTGEVVSDELDPDGDGWANIGFENIKLDEPYQTKLVQLTHLKDTGKMSTTEYNEKVAALISEAKSIDTSQSQELPSAGEAEINLVLVIFGLCISLIGMVTVMASRKRKSE
>CP017428.1|AVO01244.1|497114_498461_-|sulfite-reductase-subunit-alpha
MKPNTFNPMQRLHFYAAVFITPLLITLTLSGIAYLFFPEVENQLYKHEFYGQSEHTKQQSMTDAIKQIEKEHPGYTINKVSVMESPYNNRITIGDMEGNSYYIFLDNHNQIVDQQNAKYTYSNMVRSIHSSLSTENTAINYLVELTACWTVFMILSGIYMLVRKKLLKSNNKVLKFQKWHAIVGLIIAIPMLILVFTGLPWSGFMGAKINQISTAYPQLGQTQLVANPPKSEANEIPWALRQKAAPQSEGGGHHGSMAMPMTNIPGQLSLDKVIHNAEKQGLTRPFAIVYPTSPDGSFTLSKASNSGVTGFDVAPEKETTRYMDQYTGKQLGKVDYQDYGILAKWLTWGIPLHEGHLFGMANKIINLLVCIAFLGGIIFGFMSWFRRLKHMKQAEMLPRRVKKPMSISLIITLIILGVLMPLFGFSLIIVFIIETLLYLKDKRNKQLN
>CP017428.1|AVO01243.1|495177_496977_+|beta-glucuronidase
MLYPITTETRNIIDLNGTWKFRLEHANEKLDATQPLDTDLVMSVPGSYNEQGAISEIRNHVGTVFYERDFIVPKALRDERLVLRFGSATHEAIVYIDGEEVVSHKGGFLPFEVDITDKVGAGSHRLTVSVNNILDHSTLPVGNYEEFTDEDGNLIRKNTPNFDFFNYSGLHRPVKIYTTPHKYVEDITVVPKVEGDNATVRYETEVVGDVEEIRVELLDEEGTIVGSATGAQGDIKVENPRLWEPLNAYLYNLKVTLFDNGEVVDTYTERVGIRSVEVKDGQFLINNKPFYFKGFGKHEDTPINGRGYNENANVMDLNLMKWINANSFRTAHYPYSEEMMRLADEQGIVVIDETTAVGVHLNFLVHLGKSNNPIDTWKDIKTKEAHEQVIRELIARDKNHACVVMWSIANEPESDAKGAKEYFEPLVQLARDLDPQDRPMTIVTIMFSQPDNCQVQDLVDVLCLNRYYGWYVDQGDLRAAKASLKKEMDGWSKVQPNKPIMFTEYGADTVAGLHAIDDIMFTEEYQVKYYEANHEIVDQYPQFIGEQTWNFADFETSTGHIRVQGNRKGIFTRDRKPKSVAFYFKERWANIPDFYYKTK
>CP017428.1|AVO01242.1|494314_495157_+|D-mannonate-oxidoreductase
MIPYEIDLNNKTVVVTGGNGVIGSAMSKSLAQVGANIAIIGLNDETGAQVVREIEEAGGKALFISASVTDKAQMEQAKTKIHEALGKVDVLINGAGGNHPKGTTDDEHFDKDNKDQMQTFFELDEASVGFVFDLNFLGTFIPSQVFAQDMIDNKEATIINISSMNAFTPLTKIPAYSGAKAAVSNFTQWLSVYLADTGVRVNAIAPGFLVTSQNEKLLIKEDGSYSARAEKILNATPLHRFGKPEELIGALFFLVDYRSSSFVDGVVLPVDGGFNAYSGV
>CP017428.1|AVO01241.1|493263_494310_+|mannonate-dehydratase
MKMTFRWYGKEDPISLEYIRQIPGMEGIVSAIYDVPVGEVWPLDKIEALKKEIEDAGLELSVIESVPVHEDIKLGRPTRDKYIENYQQTLRNLSKAGIKVVCYNFMPVFDWTRSDLEYRLDDGSTALIYNEDHIKKMDPLSGELALPGWDSSYTKDDLADLFKAYESVDEEKLWENLSYFINKIIPVAEEEDILMAIHPDDPPWNIFGLPRIITNKENLERFINLYDSKSNGLTMCSGSLGCDKNNDFPEMLRYFGKKDRVHFVHARNIKHTGTHSFEESAHPSEKGSLDMYEIVKAMHDFGYEGPVRPDHGRMIWGETGKPGYGLYDRALGATYLIGLYEAVSKGKE
>CP017428.1|AVO01240.1|491845_493267_+|glucuronate-isomerase
MAFINETFMLHNDKAVQLYEDYAKDMPIYDYHCHLDPKQISEDHHFDNITDLWLSGDHYKWRVMRAQGIEEHYITGDADKKEKFVKWAQALQNAVGNPVYHWSQLELAMYFGVYDLLTEDNAEEIYERVNQYLKDNHVTTQSLIKESKVNLICTTDNPTDDLHYHDEIKAQSDFKTAVLPAFRPDAAFKIGSQDFLDFVEKLAEITQPIQSVESFIDSLKQRIDYFHSKGGRLADHGLERIDYEDFTSEEITDIFRKALNKETVSDFEKAQFITFVLNELSKAYADKGWTMQIHFGAIRNNNTRAFEKLGPDTGFDSINDQTNLAYNLNHLLDMMEREDHLPKTILYNLNPNYNDVVGSTIANFQTEPGIASKIQHGAGWWFNDTKRGMLRQMSSLADQGMLMHFVGMLTDSRSFISYARHEYFRRILCTYIGEMVENGEIPDEPSLLEKLIKGICYNNAYHYFGLIKEENNQ
>CP017428.1|AVO03245.1|505671_506745_+|hypothetical-protein
MDHTSPTHPGTKIGPKYFLFNLLNGVAIGIVAGLIPNAILGEILKALVPFNPVFTQLLHITTAIQFAVPCLIGALVAYRFKFTPLGIAVVSAASFIGSGAVVFKHNAWVITGIGDLINTMFAAAIASLMILFIGERFGSLNLIILPTFVAVSTGFIALHTLPYVKLVTTAIGNMVNSFTELQPIPMCILISLVYASIVISPISTAALSMAIGIEGLAAGSASIGIAAVEAVLTIGTLRVNRLGVPMTIFLGGVKMMLPNLVRHPIIFLPITTTAAVTGFVASLIGIGGTKESAGFGIIGLVGPINAFRFLDYGDFWLKAILCAVAFFIVPFIIAFIAHFVYSKIFKIYDEEIFKFID
>CP017428.1|AVO03246.1|506999_508058_+|hypothetical-protein
MTRPGTKVSVGTFFYNVLNGVAFAIIAGLVPHAVLGEILKALSPYSKSAGVLLQVATAIQFTVPMLVGALVAHRFKFTPLGIAVVAAASFIGSGAAQFKNGAWVITGIGDLINTMLAASIASLLILFIGERFGSLNLIILPTFVAVITGFITLHTLPYVKLVTTGIGHIINTFTEMQPVLMCMLIAIAYSMIIISPISTVATSMAIGISGLAAGAASIGITAAEATLVFGTITVNRLGVPATILLGGVKMMLPNMVKYPVMLVPITVTAAISGFVASFIGIGGTKESAGFGIIGMVGPINAFRFMHVDEVWLKLVLIITAFFVVPFTVAYIAHFIFIKIFKLYDKEIFRFLG
>CP017428.1|AVO01249.1|508563_509295_+|allophanate-hydrolase
MDYQIISEQAILVRFEPQIAPETFKKVQQLVVYLERQDHEAIKEIVPSYRAVMIHFDDHKIHAKALIENLKLDTLDVSDIETSESSKVVRIPVIYGGKYGPDIEEVAKLNDLTVEDVIQLHTEPTYLIYMLGFMPGFPYLGGLDERLYTPRRDEPRVRIDAGSVGIAKNQTGLYPQDSPGGWQIIGRTPLDVFDLDREPMTLYEAGDRIEFYQISQDTYDEIIAQKNDPDFDIERWVTVQDEH
>CP017428.1|AVO01250.1|509284_510292_+|allophanate-hydrolase
MSIRIIKPGLFSTIQDIGRYGYQKEGFSSAGALDRYSYRLGTQLIGNEGPAIEATIIGPTLQFLEDNTVVITGAEFKATLNGEPISHQTVVQVYKGDVLALNAAIKGARGYLHFGHPIDVPEVAGSYATHTRTKMGGFHGRALRKDDMIPVHYNNDYRRHVGYTSDLDLIHEGTDAIRVVEGPQYDSFPDASHEALVSEPFEISEQSDRMGFRLKGASIPPTDSADIISEPVALGSVQVPNDGNPIVLMNDKQTVGGYTKIATVCQSDLSVLAQKQPGQKVNFEWVTVEEAIQHLDDYNKGFEASLEAIEKEPLFDMREMRTTSKRISELLEGDE
>CP017428.1|AVO01251.1|510294_510738_+|acetyl-CoA-carboxylase-biotin-carboxyl-carrier-protein-subunit
MKLEEIKDLINLVKENKVNKFKYKDEAHEIELDFSSPQQTQPATQIQNQATSNPAPEAAQEPQADNQASGETVNAPMVGTFFLQDTKELTEPIVKVGDKIKKGDVIGYIEAMKVMNEVTSEVEGEVTDILVDHGTNVEYDQALIEVK
>CP017428.1|AVO01252.1|510755_512120_+|acetyl-CoA-carboxylase-biotin-carboxylase-subunit
MYRCLIANRGEIAVRIIRACREVGVETVAVYAKGDEKSLHVSLADQAICIGEANPLDSYLNINRIIAAAEITGANAIHPGYGFLSESPNFAQKVEENDIYFIGPTKRTMEMMGDKITARQTVESADVPIIPGSIGAVHSVDEIKEIAKDIGYPVVLKAASGGGGKGIRIVKEPEHLEKAFKEAQSEGKKYFDDDRIYVEAFIPVAKHVEVQVIGDGKENYVHLGERDCSVQRKNQKLIEESPCAALSEEKRQKICEDAVKVAQASNYRSAGTIEFLVTDDAYYFIEMNARIQVEHTVTEMRADRDLLQAQLYLMKHGELPFSQDDIHFTGHVIEARINAENPERKFQPSPGKVKALHLPQGFNVRVDSLLYPGYVVSPYYDSLVAKVIVKGANRTHAIEKLKATLDEMVIDGFSTTADFLYAVLSYPAYADGDAKDVDIKFLDRHQITKGAALT
>CP017428.1|AVO01253.1|512116_512875_+|lactam-utilization-protein-LamB
MKIDLNCDLGEAFGNYSFGGDHQIIPLITSANIACGFHAGDENVMYETVKLAKENGVGIGAHPGFHDIQGFGRRNMDLSPDEIYTLVAYQIGALSAFCRIHDVKINHVKPHGALYNMGARDKDIAHAIAQAVYDVDPSLILVGLSNTLLVSEAEAVGLKAANEVFADRRYEENGQLVSRKEADAVLTDTDEAIEQVVKMVKENKVIAKTGKEIELKADTICVHGDGAHALEFVSKIRERLTKEGISITKLGG
>CP017428.1|AVO01254.1|512878_514108_+|iron-transporter
MGENKQNKPEFQFTKEHKRLLLGSVFLMATSAIGPAFLTQTAVFTQQFAASFAFAILLSIIIDIGAQINIWRILVVTGLRGQEIANKMVKGLGTFISILVAIGGLAFNIGNVAGAGLGLNAIFGIDVKWGAAITAILAIGVFISKSGQKVMDFVTMILGVMMIGITAYVMVKSNPPYLEAAEKMVMPEHPGALVLPIITLIGGTVGGYITFAGAHRILDSGIKGKDYLPFVNHSAIAGILTTGVMRGLLFLAVLGVVVTGVTLNPENPPASVFEHALGPIGKNIFGIVLFAAALSSVIGSAYTSATFLKTLSKSLMKRSNIIVIVFIVVSTITFLLIGKPVKLLIIAGALNGLILPITLGVILIASKKKSIVGDYKHPTWMLMFGVLAVLVTIVTGFLSFQGLADLWNS
>CP017428.1|AVO01255.1|514333_515830_+|xylulokinase
MTTEAVIGIDLGTSAIKLIAVDRLGNVLGTQSEPLKLYHDYPGYSEQAPEEWVAAAVNGLHHLLAQPVLSDVSIEGLSFSGQMHGLVIVDQAGQPLRRAILWNDTRTTPQCEQIKVKYGDQVLGNPVVEGFTLTKLLWVQQHEPDLFKQIDTFMLPKDYLRFALTGVLHTEYSDAAATMLLNPQTKAWDKALGASFDIPDHIYPDLVESHAQVGVLKAELQQQLSLNKPVPVFAGGADNACAALGSGVIHPDDAICSIGTSGVLLICEPVGESEGYGHKIHLMNHAVPDVNYLMGVTLSAGYSLSWFKREFYPEDDFTTLMKDAEASQIGAHGLIFTPYLVGERTPHGDASIRGSFIGITGNHTRGDFGRAVVEGITYSLYDSLVYLRSIGRNVTKIVSTGGGAKSDFWLQLQANVFNTEIYKLKHEEGPSMGAAMLAAYSLSWYDSLKDCAEAFIHYSKVFQPDLKRHQTYEAYFEIYQQAYQATRHLTSDLLALQK
>CP017428.1|AVO01256.1|515896_516076_-|hypothetical-protein
MSFKEYVEDVVETIKHMRFGSKNGIIMIVSAIVLSAITTPIIGLPLGAWIGYYLEKNGK

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Crispr_ID: CP017428_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP017428_2

1840995-1841619

TypeII

Consensus_repeat	Method
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	CRISPRCasFinder
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	CRT
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	PILER-CR

9 spacers

cas2,cas1,cas9

The CRISPR arrays of CP017428_2

>merge|CP017428|2|1840995-1841619|CRISPRCasFinder,CRT,PILER-CR
TGTTTAAATCATTCTAAAAGATCACAATTCTAAAACTTTAAGAGCATGTAGCTATGATTTGGATAGTTTTACTTCATTCTAAAAGATCACAATTCTAAAACACGATAGTTATTAAACGATAGTTATTAAAGTTTTACTTCATTCTAAAAGATCACAATTCTAAAACAAAGGCTTAAATGGTTCTCAAATCATCTCAGTTTTACTTCATTCTAAAAGATCACAATTCTAAAACCCCACAACGCCAGCATTGCCGTTTTCTTTTGTTTTACTTCATTCTAAAAGATCACAATTCTAAAACAAAACCCTACGAATGTGTTGATAACGTTTGTTTTACTTCATTCTAAAAGATCACAATTCTAAAACACACCAACAATTTTTCCGACTTCCTCCAACGTTTTACTTCATTCTAAAAGATCACAATTCTAAAACTTTTTCTGCCCTTTTTTATAATTTAATTGGTTTTACTTCATTCTAAAAGATCACAATTCTAAAACCTGATGTTTCGTCATTGCTTGTCTTGCTGCGTTTTACTTCATTCTAAAAGATCACAATTCTAAAACTTAATCGTCGTTTTATTATTTATTAAACAGTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC

>CP017428|2|2|1840995-1841619|CRISPRCasFinder
TGTTTAAATCATTCTAAAAGATCACAATTCTAAAAC	TTTAAGAGCATGTAGCTATGATTTGGATA
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	ACGATAGTTATTAAACGATAGTTATTAAA
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	AAAGGCTTAAATGGTTCTCAAATCATCTCA
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	CCCACAACGCCAGCATTGCCGTTTTCTTTT
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	AAAACCCTACGAATGTGTTGATAACGTTT
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	ACACCAACAATTTTTCCGACTTCCTCCAAC
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	TTTTTCTGCCCTTTTTTATAATTTAATTG
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	CTGATGTTTCGTCATTGCTTGTCTTGCTGC
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	TTAATCGTCGTTTTATTATTTATTAAACA
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC

>CP017428|2|2|1840995-1841619|CRT
TGTTTAAATCATTCTAAAAGATCACAATTCTAAAAC	TTTAAGAGCATGTAGCTATGATTTGGATA
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	ACGATAGTTATTAAACGATAGTTATTAAA
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	AAAGGCTTAAATGGTTCTCAAATCATCTCA
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	CCCACAACGCCAGCATTGCCGTTTTCTTTT
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	AAAACCCTACGAATGTGTTGATAACGTTT
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	ACACCAACAATTTTTCCGACTTCCTCCAAC
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	TTTTTCTGCCCTTTTTTATAATTTAATTG
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	CTGATGTTTCGTCATTGCTTGTCTTGCTGC
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC	TTAATCGTCGTTTTATTATTTATTAAACA
GTTTTACTTCATTCTAAAAGATCACAATTCTAAAAC

>CP017428|2|2|1840997-1841619|PILER-CR
TTTAAATCATTCTAAAAGATCACAATTCTAAAACTT	TAAGAGCATGTAGCTATGATTTGGATAGT
TTTACTTCATTCTAAAAGATCACAATTCTAAAACAC	GATAGTTATTAAACGATAGTTATTAAAGT
TTTACTTCATTCTAAAAGATCACAATTCTAAAACAA	AGGCTTAAATGGTTCTCAAATCATCTCAGT
TTTACTTCATTCTAAAAGATCACAATTCTAAAACCC	CACAACGCCAGCATTGCCGTTTTCTTTTGT
TTTACTTCATTCTAAAAGATCACAATTCTAAAACAA	AACCCTACGAATGTGTTGATAACGTTTGT
TTTACTTCATTCTAAAAGATCACAATTCTAAAACAC	ACCAACAATTTTTCCGACTTCCTCCAACGT
TTTACTTCATTCTAAAAGATCACAATTCTAAAACTT	TTTCTGCCCTTTTTTATAATTTAATTGGT
TTTACTTCATTCTAAAAGATCACAATTCTAAAACCT	GATGTTTCGTCATTGCTTGTCTTGCTGCGT
TTTACTTCATTCTAAAAGATCACAATTCTAAAACTT	AATCGTCGTTTTATTATTTATTAAACAGT
TTTACTTCATTCTAAAAGATCACAATTCTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP017428.1\|AVO02499.1\|1851535_1852330_-\|glyoxalase	unknown	unknown	gnl\|CDD\|225312
CP017428.1\|AVO02495.1\|1848120_1849437_+\|ISL3-family-transposase	unknown	unknown	gnl\|CDD\|225995
CP017428.1\|AVO02490.1\|1838550_1839852_-\|uracil-permease	unknown	unknown	gnl\|CDD\|236744
CP017428.1\|AVO02482.1\|1829027_1829639_-\|orotate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234771
CP017428.1\|AVO02500.1\|1852508_1855256_-\|isoleucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235588
CP017428.1\|AVO02494.1\|1843725_1847760_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	mkCas0193_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
CP017428.1\|AVO02488.1\|1836353_1837625_-\|dihydroorotase	unknown	unknown	gnl\|CDD\|236479
CP017428.1\|AVO02484.1\|1830344_1831262_-\|dihydroorotate-dehydrogenase-B-catalytic-subunit	unknown	unknown	gnl\|CDD\|235982
CP017428.1\|AVO02483.1\|1829640_1830345_-\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234695
CP017428.1\|AVO02492.1\|1841669_1842521_-\|hypothetical-protein	unknown	unknown	unknown
CP017428.1\|AVO02497.1\|1850431_1850914_-\|signal-peptidase-II	unknown	unknown	gnl\|CDD\|234739
CP017428.1\|AVO02496.1\|1849501_1850419_-\|pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
CP017428.1\|AVO02489.1\|1837611_1838520_-\|aspartate-carbamoyltransferase	unknown	unknown	gnl\|CDD\|234849
CP017428.1\|AVO02485.1\|1831258_1832023_-\|dihydroorotate-dehydrogenase-electron-transfer-subunit	unknown	unknown	gnl\|CDD\|99814
CP017428.1\|AVO02486.1\|1832080_1835254_-\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
CP017428.1\|AVO02493.1\|1842860_1843736_-\|subtype-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
CP017428.1\|AVO02491.1\|1840073_1840601_-\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|235365
CP017428.1\|AVO02498.1\|1851043_1851529_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226451
CP017428.1\|AVO03279.1\|1842517_1842826_-\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
CP017428.1\|AVO02487.1\|1835246_1836347_-\|carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139

Protein	Function_ID	Function_description	E-value
CP017428.1\|AVO02499.1\|1851535_1852330_-\|glyoxalase	gnl\|CDD\|225312	COG2514, COG2514, Predicted ring-cleavage extradiol dioxygenase [General function prediction only].	4.78216e-79
CP017428.1\|AVO02495.1\|1848120_1849437_+\|ISL3-family-transposase	gnl\|CDD\|225995	COG3464, COG3464, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	5.93462e-66
CP017428.1\|AVO02490.1\|1838550_1839852_-\|uracil-permease	gnl\|CDD\|236744	PRK10720, PRK10720, uracil transporter; Provisional.	7.17605e-143
CP017428.1\|AVO02482.1\|1829027_1829639_-\|orotate-phosphoribosyltransferase	gnl\|CDD\|234771	PRK00455, pyrE, orotate phosphoribosyltransferase; Validated.	4.78352e-77
CP017428.1\|AVO02500.1\|1852508_1855256_-\|isoleucine--tRNA-ligase	gnl\|CDD\|235588	PRK05743, ileS, isoleucyl-tRNA synthetase; Reviewed.	0
CP017428.1\|AVO02494.1\|1843725_1847760_-\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	1.91047e-107
CP017428.1\|AVO02488.1\|1836353_1837625_-\|dihydroorotase	gnl\|CDD\|236479	PRK09357, pyrC, dihydroorotase; Validated.	0
CP017428.1\|AVO02484.1\|1830344_1831262_-\|dihydroorotate-dehydrogenase-B-catalytic-subunit	gnl\|CDD\|235982	PRK07259, PRK07259, dihydroorotate dehydrogenase.	6.45178e-174
CP017428.1\|AVO02483.1\|1829640_1830345_-\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234695	PRK00230, PRK00230, orotidine-5'-phosphate decarboxylase.	1.78708e-129
CP017428.1\|AVO02497.1\|1850431_1850914_-\|signal-peptidase-II	gnl\|CDD\|234739	PRK00376, lspA, lipoprotein signal peptidase.	1.37287e-51
CP017428.1\|AVO02496.1\|1849501_1850419_-\|pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	6.39179e-124
CP017428.1\|AVO02489.1\|1837611_1838520_-\|aspartate-carbamoyltransferase	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	1.56537e-169
CP017428.1\|AVO02485.1\|1831258_1832023_-\|dihydroorotate-dehydrogenase-electron-transfer-subunit	gnl\|CDD\|99814	cd06218, DHOD_e_trans, FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to orotate coupled with the reduction of NAD+. In L. lactis, DHOD B (encoded by pyrDa) is co-expressed with pyrK and both gene products are required for full activity, as well as 3 cofactors: FMN, FAD, and an [2Fe-2S] cluster.	3.691e-122
CP017428.1\|AVO02486.1\|1832080_1835254_-\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
CP017428.1\|AVO02493.1\|1842860_1843736_-\|subtype-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	3.23461e-92
CP017428.1\|AVO02491.1\|1840073_1840601_-\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase	gnl\|CDD\|235365	PRK05205, PRK05205, bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR.	1.72282e-88
CP017428.1\|AVO02498.1\|1851043_1851529_-\|hypothetical-protein	gnl\|CDD\|226451	COG3942, COG3942, Surface antigen [General function prediction only].	9.18985e-30
CP017428.1\|AVO03279.1\|1842517_1842826_-\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	5.44995e-28
CP017428.1\|AVO02487.1\|1835246_1836347_-\|carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0

>CP017428.1|AVO02491.1|1840073_1840601_-|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase
MTERIVLDDAGMQRTLTRIAHEILEYNKGTENLVLLGVKTRGEFLAKRIQTKIQQIEDVSVPTGTLDITQFRDDLELPTPKMSEKSYVIDVDLKDKVVIIIDDVLYTGRTVRASLDAILLHSRPQKIGLATLVDRGHRELPIRADFVGKNIPTAKDEEVLVYVDETDGRNAVIIE
>CP017428.1|AVO02490.1|1838550_1839852_-|uracil-permease
MENEQMFERTVKPVLDVNEKPKAGQWAFLSLQHLFAMFGATVLVPFLTGLPISAALLASGIGTLLYILITKSMIPAYLGSSFAFITPIITGLSTHSLGDMLVALFMSGVMYVIIGILIKLSGIGWLMHLLPPVVVGPVIMVIGLSLAPTAANMAMFENTADMKGYNVTYLIVAMITLITTLVVQGYMKGFFSLIPVLIGIIVGYIAGIIFGIVDFKPVMKASWFDWPHIYVPFVDYHPSFHFGLVLLMVPIVFVTVSEHIGHQMVINKIVGRNFFEKPGLHRSIIGDGVSTMFASIIGGPPSTTYGENIGVLAITKIYSIYVIGGAAVIAIILAFVGKFTALISSIPTPVMGGVSILLFGIIASSGLRMLVESKVDFSENRNLVIASVILVVGIGNLMFDIHGVKVEGMALASLSGIVLNLILPKVKPETSNK
>CP017428.1|AVO02489.1|1837611_1838520_-|aspartate-carbamoyltransferase
MKQLVSMEHLSNEEIYSLIETAIEYKQGKKVHKLNDTYVANLFFENSTRTKCSFEMAERRLGMQEIPFETSTSSVKKGESLYDTCKTLESIGVDALVIRHPQNDYYKELEGLNIPVINGGDGSGQHPTQSLLDIMTIYEEYKKFKGLNVLICGDIKNSRVARSNYQALTALGANVKFAAPDEWVDDTLDAPYVKIDDVIEETDIVMLLRVQHERHDGELNFDPHEYHEKYGLTKERYNRMKPNAIVMHPAPVNRGVEIDTELVEAPKARIFKQMKNGMFLRMSVISHIIAEQQKGVLIDVAN
>CP017428.1|AVO02488.1|1836353_1837625_-|dihydroorotase
MLLIKNAKVLKDGKLTEASILVEDDKVKEIAPEITVGSEVEVIDAKGRFAAPGLVDVHVHLREPGGEHKETIETGTKAAARGGFTTVCPMPNTRPVPDTVEHLEKLNKLIEDNARVRVLPYASITIRQAGSELVDFKGLAEHGAFAFTDDGVGVQTAGTMYEAMQQAAKLNKAVVAHCEDNSLIYGGAMHEGKRSKELGIPGIPNICEAVQIARDVLLAEAADCHYHVCHVSTKESVRAIRDAKAAGIKVTAEVTPHHLLMTEDDVPGDNAMYKMNPPLRSKEDRDALIEGLLDGTIDCIATDHAPHAADEKAQPMTKAPFGIVGSETAFPLLYTHFVKNGDWSLQQLVDYLTIKPAQIFDLPYGILEEGKTADLTLINLEEEREIKAEDFHSKASNTPFIGYKVYGNPVLTMVAGEVAFKEE
>CP017428.1|AVO02487.1|1835246_1836347_-|carbamoyl-phosphate-synthase-small-subunit
MLEKRYLVFEDGSIYEGRKLGSDNLTKGEIVFNTAMTGYQETISDPSYTGQIITFTYPLIGNYGINRDDFESLVPTLSGVVVKEASTHPSNFRQQKTFNDVLVQYDIPGISGVDTRSITRKIREHGVLKAGFTDHAEDIPSFIEELKQFELSRDEVPMVSTKTPYVSTGSDLSVVLVDFGKKQNIVRELNARGCNVTVVPYNTPAEIILGMSPDGVMLSNGPGDPEDVPEAVEMIQGILGKIPFFGICLGHQLFALSQGAEAFKMKFGHRGANHPVKDLATGKIALTSQNHGYAIDEASVAHTDLEVTHIALNDGTVEGLKHKTLPAFSVQYHPEACPGPTDSNYLFDQFIDMMNEFKAKEHTVNA
>CP017428.1|AVO02486.1|1832080_1835254_-|carbamoyl-phosphate-synthase-large-subunit
MPRNNDIKTILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYRVILVNSNPATIMTDKEIADKVYIEPLTHDFIARIIRKEQPDALLPTLGGQTGLNMAIQLHDSGVLEANNVRLLGTKLSSIQQAEDRELFRSLMNDLDVPVPESDIVHTVEQAFAFKEQVGYPLIVRPAFTMGGTGGGICHNDEELKEVVTNGLHYSPATQCLIEKSIAGFKEIEYEVMRDKNDNAIVVCNMENIDPVGIHTGDSIVVAPSQTLTDVEYQMLRDVSLKVIRALGIEGGCNVQLALDPYSMNYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLTLDEMLNPVTGTSYAAFEPALDYVISKIPRFPFDKFEKGERVLGTQMKATGEVMAIGRTYEESLLKAIRSLEYGVHHLGLPNGESYDLDYIKERILQQDDERLFFIGEAIRRGTTLEEIHEMTKIDYFFLNKFQHIIDIERELKAHKGDIEYLKYAKDYGFSDKVIAHRFDMEEADVYRLRHENDIKPVYKMVDTCAAEFESATPYYYGTYERDNESIATDKEKVIVLGSGPIRIGQGVEFDYATVHAVWAIQNAGYEAIIVNNNPETVSTDFSISDKLYFEPLTEEDVMNIIELEQPKGVVVQFGGQTAINLAEKLAKHGVQILGTSLENLNRAEDRKEFEELLNTIDVPQPKGKTATSPAEALDNAREIGYPVVVRPSYVLGGRAMEIVYNDAELENYMREAVKASPEHPVLVDRYLTGKEIEVDAISDGETVIIPGIMEHIERAGVHSGDSIAVYPPQTLSDEVIQTLEAYTTKLAKGLDIIGLINIQFVLAHDGVYVLEVNPRSSRTVPFLSKITDIPMAQLAMRAILGEKLSELGYKPGLQPYSEGVYVKAPVFSFNKLKNVDITLGPEMKSTGEVMGKDLTLEKALFKGLTASGVEVKDHGTVLITVSDKDKEEMVKIEKRLHEVGYKVLATSGTAAKLAENHIPVETVGKIGGEDDLLNRIQNGDVQIVINTMTKGKTIERDGFQIRRASVENGVPCLTSLDTANALTNVIESMTFTMRSM
>CP017428.1|AVO02485.1|1831258_1832023_-|dihydroorotate-dehydrogenase-electron-transfer-subunit
MEQNIIVSNREIADRIFEIKVKGPVTRKMTQPGQFVHIKVGEGSLHMLRRPISICHIEPEIETFTMLYRAEGAGTQRLSQMRENDAIDIIAPLGNGFPVEKAERKALLVGGGIGVPPLYELSKQLNRQGIETVHVLGFRSKKDVFYADEFAQLGETHIVTEDGTMGAKGFVTNVISELPVDYDIYYTCGPKPMLKAIKEHDKLADVEGFLSLEERMGCGIGACYACVCHTPESETSYVKVCTDGPVFEKGAVIL
>CP017428.1|AVO02484.1|1830344_1831262_-|dihydroorotate-dehydrogenase-B-catalytic-subunit
MSRLNVEIPGLELKNPIMPASGCFAFGAEFSQFYDLSELGAIMIKAATKEARYGNETPRVAETDSGMINAIGLQNPGVHHIIEHELKKLEQFDVPIIANVAGSTEEDYVYVAEHISKAPNVKALELNISCPNVKEGGMQFGVDPVVAAELTRKVKAVSEVPVYVKLSPNVTDIVAMAKAIAQYADGLTMINTLVGLRIDAKTGRPIIANTVGGLSGPAIKPVAMRMVYQVRQAVDIPIIAMGGVQNAQDVIDYISVGANAVAVGTANFQNPMVCKEIIDELPALLDDLGVNHINELYKRTFEVTK
>CP017428.1|AVO02483.1|1829640_1830345_-|orotidine-5'-phosphate-decarboxylase
MANRNLPLPIIALDFATAEEVENFLDLFDEPLYIKIGMELYYQTGPELINKIKARGHQIFLDLKLHDIPNTVKQAMAGLGRLNVDLVNVHAAGGTEMMRQAVEGLRSVNKDTKIIAVTQLTSTTEEMLQKEQNIQTSIEEAVLNYARLTKEAGLDGVVCSPLEAELLTKELGSDFLKVTPGIRPAHYAQDDQKRITTPDKAREMGSTHIVVGRPITQSDNPVESYHHIKESWLG
>CP017428.1|AVO02482.1|1829027_1829639_-|orotate-phosphoribosyltransferase
MSKQIAQSLLDIGAVALSPNDLFTWSSGIKSPIYCDNRVTLGYPEVRNAIRDGLIELIQTHFKDAEIVSGTATAGIPHAAFISEKLDMPMSYVRSKSKSHGKQNQIEGAPSKGKKIVVVEDLISTGGSSLVAAEALREAGAEVLGVVAIFTYGLAKADQMFKDADIPFYTLSDYNELIDVAKEQGKISESDIQSLVEWRDNLA
>CP017428.1|AVO02492.1|1841669_1842521_-|hypothetical-protein
MKLVGEFNKPIEIAKQRLNVISFQNTSKLNALTEGLIKYSQSKSKNYDENVRLVADDYQTILPNKVNLIIVPCGDINLFDSKIFKEALYHRFEQQIFNEETTNLLYNKVESMIESFLNSLEIKNESYQVDFQSPNIVLKKLLGMFKPDFHNDLEDLNAIEQRKLFIDTLTSTEKENVLVLLFPEAHLGLSDMKAFKKYLQTLNMFSIIVTSHPYFIIESDTLALIKMNGEPVNTKQIREELLLFKEKEKITDLDKTSKMIAYHEFCQHPYLDDEFFIQFMNKY
>CP017428.1|AVO03279.1|1842517_1842826_-|CRISPR-associated-endonuclease-Cas2
MRLFIMFDLPVETSRERREYRKFVKFLLNEGYVRSQYSIYCKLILNRGTLNHQISKLKQNLPAHGIVQSLIVTEKQFSDMTYLVGEPRTKYDVNTTERILEL
>CP017428.1|AVO02493.1|1842860_1843736_-|subtype-II-CRISPR-associated-endonuclease-Cas1
MSFRTVIITKESKLSLRMNHLIVKADELYKIPLQEILCLVIENPSVSITGHLLNALSENKIITLLCDKKHLPSSFVVPIYGHHKQSRHIAKQLNWNKEYKSLLWQRIIKNKIAKQKQVIQYFYRNIDTSFFDNCVHETKLNDSTNREGLAAKSYFNIILDSGVSRNSDEFVNGGLDYGYQVLLAVFVRTIVSKGYLTEIGIKHKNEFNPFNLACDFMEVFRPMVDFLVLQNVYDKFEKEEKRAILNMFNEKVKLNKKNYFLVNAIEIYLDGIFKFLESGDINFIKMPVFNF
>CP017428.1|AVO02494.1|1843725_1847760_-|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MKKTNPYILSLDIGTASIGYACMDLDFNILKYHDKDAIGVLTFEGADTAAERRGFRTSRRSKNRRIKRLGLLQEVLAPLVKNPNFYQLLNLHKWKNSNEDFKHRSLSEVLKALGKNPKAYPTIYHLQQDIQNHPEKKFEPELIFLALYHLVKYRGHFLFNNLSFDKGKTVDNEAQLSELLEQYQSINSYEDAISNKDIKVIVDTLKDDQLTRNDKSKELKRNVSKTHAELFKMLVGLKFKQSILFENMENVEDIKESATGSDAISLSDDYYENLSEFLTDEQLNFIESANTFFMGIMLDRILKGATSISAAKVRDYKIFKNQLKLIKDIVYQNKYDKYHEFFVTSKEDMRAYQENPDAKNFGKLSKFDQYLIHPKDQYAKLMKDLKGLVPKEYTEVLNLIDEQKFLVVQNTTDNASIPYQNNVFEAENILRNQQKYYPEITEEMIGKVINLISFRIPYYVGPLTNKNGQSDFAWVIRKSDEQTLPWNFDKVIDKSKSAEKFIRRMTSKCTYLLEEDVLPKHSLLYQEMEVLNELNNVQLRGENEPKHRIHRLDPKVKQFIYHNLFQKKKNVTHKDLITLLQNSEHRNTLNKTSGQKLKVFGTQNDSKFAPKLSTYNDMKAILGSVENKRQMIEELVLWITIFEDKAILKQKIGEKYPNITEKQLNQIVKLNYSGWGRLSEKLLNKEVNGRSLIDLMYSTENNFMEIITDKTLGFDCFIKNSNKVKNAKISYKDVAELRTSPALKKGIWNAIKMVREISNLFGAPEKIIIEFATEDQAKGKRQKSRSELWDDLVKKNNLKRNKEFEGLFEELKAYPDLDFSNPKLWLYIHQNGKCMYTKKPIDLERLMSDTNNQLYEIDHILPRTFVKDDSINNKVLVIQSANQKKSGDKMPLEIFDNHVLVPFWKMLYENDLISSSKLSKLMKKEFNDLDKEGFIQRQLVETRQIISHVSDFLTEEYPSTTVVPMKANVVSELRRKFDIPKIRQLNDWHHAVDAYLNGFVYQAARVFYPKVNLFEFNFKWEKVREKWRQLGEFTENNKKREFFLFKRMENYVNEYGEGMISKLIFDLDNFKFNYSRKVESTESAFYKQSAFSPKNTTAQYDSDKNKTAIYKEMKNKRGIVVSYTYVKKDQELIGYGVFNETVFEYVNNADVDMNTRALKIVRKAFPKLDIKKAQYLFSINKGDALLVNGHPFLFVSAYERINGKQLEFDIAMQRKIKQALSPYNNMTEQEKVEFYNQFAEKVIEEFRNSIGLQSRDRKVNLIKNLFNNTEKSNDSMTQSILEVLKMTKVSAERSKELKIRWNGQTPNTFIDTKNNAEIQYKSITGLKTTKPKSIFKLAESKNEL
>CP017428.1|AVO02495.1|1848120_1849437_+|ISL3-family-transposase
MSNTISITLGIKDKNITFEDKVEERKYKGKNSLFYFGKLIHSPKRCKLCGHENTNFSIIKNGLKKSCLTIPKVSEKPAYLILEKQRFHCKKCCSYFTAETPVVERNCYISQNTRLAVLNKSIDIRSQKSVAESCHVSNSTVTRIINKAASQIAQTPFKYLPEHLMMDEFKSVKNVVGKMSFIYADAVTHRIIDIVPDRRLFALKNYFYRYPLSERKRVKTVSIDMYEPYMALIREVFPNAKILIDRFHIVQSLNRALNMTRVTVMNSFRTTERPLYNKYKRYWKILLKPYEQLEAFAYSKMPLYKQWKTPKGVVEHLLSFDERLLNTHTLVNELRSTLKENNKAAFETALKNIEINSVAPKLQTAVKTLRKHNSMIRNTFEYSNLTNGPLEVINTKIKLIQRISFGYRNFGNLRSRIILCTNLFAANPKKEIKQLYAA
>CP017428.1|AVO02496.1|1849501_1850419_-|pseudouridine-synthase
MSQFDFQITEDEHVGQRIDKFLPEQNSDWSRSQIQDWIKEGLVEVNQKVVKANYKMKKNDQVQVTEKETVEADIQPENLDLDIYYEDEDVAIVYKPKGMVVHPSPGHYSGTLVNGLMYQIKDLSGINGEIRPGIVHRIDKDTSGLLMVAKNDIAHRGLVEQLMDKTVTRKYTALVHGNIPHDYGTIDAPIGRNKVDRQAMDVVDDGKDAITHFNVLEHFNNYTLVECELETGRTHQIRVHMKYIGYPLVGDPKYGPKKTMDIGGQALHAGVIGFTHPVTGEYIERKAPLPDYFEEILEDIRTRDA
>CP017428.1|AVO02497.1|1850431_1850914_-|signal-peptidase-II
MRKSYFIGATLFVTLAVLILDQFTKAYIVKTMSVGDSYSVIPGFLNITSHRNTGAAWGILSGKMGFFFLVTIIVLGLLTYFYVKEARGHFWMQMAISLLFAGALGNFIDRMKNGEVVDFIDTYIFGYDFPIFNVADSSLTVGVILILILLLFDSKKNKVK
>CP017428.1|AVO02498.1|1851043_1851529_-|hypothetical-protein
MKKLISAGVMLVVLGGATYVAVDHQDEIEHYIEQMKPDPMAFNPYDDGECTDYVFEKVKDDGNMIGKSWGDAKYWADKAEEAGYTVNQQPKASSLLQSPRGEEGHVAYIEHVNDDGSLYVTEMNYVAPQKVTSRTIQPQQVQNYHYIHPKENPKTQDTKEA
>CP017428.1|AVO02499.1|1851535_1852330_-|glyoxalase
MRQLGEKHYVNGVTLNVRDKENLKHFYEEILGFNVINETYTSIQYEVGDSKHRITLHQIDDGREPLVSEAGLFHIGIRLGSHAHLADLMAHLTEHEIPLNGAEHNVSTSLYFTDPEGNGFEFYADQPEETWDFDKENRVIMDTRHLYASKLMNLRSRDGWQGIPDDSMIGNLHLKTVRISEVKDYYLAHFGLEESSFVNKSSLFMSSNGYHHTLAVNHWMSSMQRMENDDTYGLTLVDFHYPETTHTWLKGPDGIAFRFNYLGV
>CP017428.1|AVO02500.1|1852508_1855256_-|isoleucine--tRNA-ligase
MNYKETLLMPKTDFPMRGGLPKKEPEIQKQWDEQDLYHKILEKNKGNETYILHDGPPYANGNLHMGHALNKILKDFIVRYKSMQGYYSPYVPGWDTHGLPIEQALTKKGVKRKEMPVSEFRELCKEFALEQIDIQKKDFKRLGVNGDFNDPYITLKPEYEAAQIRLFGEMADRGLIYKGKKPVYWSPSSESSLAEAEIEYHDKRSPSIYVAFDVKDGKGVVDEDAKFIIWTTTPWTLPSNVAITVHPELKYGQYKVNGEKYVVGTDLVEEVAEALDWDKDAIELEKTFTGKELEYVETQHPFVDRVSLVINGLHVTTDAGTGAVHTAPGHGEDDYIVGQKYGLPVISPLDDKGVFTEEGGQFEGMFYDKANKAVTDLLKENGSLLKLQFITHSYPHDWRTKKPVIFRATPQWFASISKVRQDILDAIEETHFKVDWGKTRIYNMIRDRGEWVISRQRVWGVPLPVFYAENGDIIMDKEVIYHVANLFEKYGSNVWFDREAKDLLPEGFTHPGSPNGEFTKEEDIMDVWFDSGSSHRGVLETRPELSFPADLYLEGSDQYRGWFNSSITTSVATRGQSPYKFLLSHGFVMDGEGKKMSKSLGNVIVPDQIVKQKGADIARLWVSSVDYLSDVRISDEILKQTADVYRKIRNTLRFMLGNVNDFNPSTDALDEADLLEVDRYLLNRLREFTANIIKHYDNFDYLNIYQEVQNFINVELSNFYLDYGKDILYIEKQDSPKRRSMQTVLYQILVDMTKLLAPILAHTAEEVWSYIPHVEEESVHLANMPKVVEPDTALLEKWNTFMKLRDDVNRALESARNDKVIGKSLEAKVIIGSNEHFDATSFLKDFENLQQLFIVSQVEVEDKVEDGTEYYHGDIKVVHADGEKCERCWNYSTELGSANGLDHLCPRCQAVVETL

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP017428_1	1.1\|504960\|29\|CP017428\|PILER-CR,CRISPRCasFinder,CRT	504960-504988	29	NZ_AP019752	Staphylococcus aureus strain JRA307 plasmid pJRA307-1, complete sequence	27166-27194	2	0.931
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_KM348008	Bacillus pumilus strain 15.1 plasmid pBp15.1S, complete sequence	2599-2627	4	0.862
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_KM348008	Bacillus pumilus strain 15.1 plasmid pBp15.1S, complete sequence	2599-2627	4	0.862
CP017428_1	1.1\|504960\|29\|CP017428\|PILER-CR,CRISPRCasFinder,CRT	504960-504988	29	MT773554	Myoviridae sp. isolate BML_2 genomic sequence	11973-12001	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP013709	Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence	46331-46359	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP013844	Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence	92416-92444	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NC_021496	Lactobacillus reuteri I5007 plasmid pLRI02, complete sequence	14780-14808	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	MG516911	Proteus mirabilis plasmid pPm60, complete sequence	50065-50093	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP047114	Proteus mirabilis strain SCBX1.1 plasmid plas1.1.2, complete sequence	39404-39432	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP053899	Proteus mirabilis strain YPM35 plasmid pJPM35-1, complete sequence	109636-109664	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP053895	Proteus mirabilis strain JPM24 plasmid pJPM24, complete sequence	79715-79743	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP047288	Proteus cibarius strain G11 plasmid p152, complete sequence	69127-69155	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP053372	Proteus cibarius strain G32 plasmid pG32-177, complete sequence	64382-64410	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP053043	Proteus cibarius strain HNCF44W plasmid pHNCF44W_NDM-1, complete sequence	102225-102253	5	0.828
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP053897	Providencia rettgeri strain YPR31 plasmid pYPR31, complete sequence	82946-82974	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP013709	Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence	46331-46359	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP013844	Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence	92416-92444	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NC_021496	Lactobacillus reuteri I5007 plasmid pLRI02, complete sequence	14780-14808	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	MG516911	Proteus mirabilis plasmid pPm60, complete sequence	50065-50093	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP047114	Proteus mirabilis strain SCBX1.1 plasmid plas1.1.2, complete sequence	39404-39432	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP053899	Proteus mirabilis strain YPM35 plasmid pJPM35-1, complete sequence	109636-109664	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP053895	Proteus mirabilis strain JPM24 plasmid pJPM24, complete sequence	79715-79743	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP047288	Proteus cibarius strain G11 plasmid p152, complete sequence	69127-69155	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP053372	Proteus cibarius strain G32 plasmid pG32-177, complete sequence	64382-64410	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP053043	Proteus cibarius strain HNCF44W plasmid pHNCF44W_NDM-1, complete sequence	102225-102253	5	0.828
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP053897	Providencia rettgeri strain YPR31 plasmid pYPR31, complete sequence	82946-82974	5	0.828
CP017428_1	1.1\|504960\|29\|CP017428\|PILER-CR,CRISPRCasFinder,CRT	504960-504988	29	NZ_CP011248	Agrobacterium tumefaciens strain Ach5 plasmid pAt, complete sequence	157027-157055	6	0.793
CP017428_1	1.1\|504960\|29\|CP017428\|PILER-CR,CRISPRCasFinder,CRT	504960-504988	29	NZ_CP032919	Agrobacterium tumefaciens strain 15955 plasmid pAt15955, complete sequence	156788-156816	6	0.793
CP017428_1	1.1\|504960\|29\|CP017428\|PILER-CR,CRISPRCasFinder,CRT	504960-504988	29	NZ_CP033029	Agrobacterium tumefaciens strain A6 plasmid pAtA6, complete sequence	156872-156900	6	0.793
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP045855	Agrobacterium sp. MA01 plasmid punnamed1, complete sequence	63502-63531	6	0.8
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP014171	Clostridium tyrobutyricum strain KCTC 5387 plasmid pCTK01, complete sequence	21003-21031	6	0.793
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	CP016281	Clostridium tyrobutyricum strain W428 plasmid pW428, complete sequence	15738-15766	6	0.793
CP017428_2	2.8\|1841489\|30\|CP017428\|CRISPRCasFinder,CRT	1841489-1841518	30	MN694376	Marine virus AFVG_250M360, complete genome	1914-1943	6	0.8
CP017428_2	2.8\|1841489\|30\|CP017428\|CRISPRCasFinder,CRT	1841489-1841518	30	MN694177	Marine virus AFVG_250M361, complete genome	37138-37167	6	0.8
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP014171	Clostridium tyrobutyricum strain KCTC 5387 plasmid pCTK01, complete sequence	21003-21031	6	0.793
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	CP016281	Clostridium tyrobutyricum strain W428 plasmid pW428, complete sequence	15738-15766	6	0.793
CP017428_2	2.17\|1841491\|30\|CP017428\|PILER-CR	1841491-1841520	30	MN694376	Marine virus AFVG_250M360, complete genome	1914-1943	6	0.8
CP017428_2	2.17\|1841491\|30\|CP017428\|PILER-CR	1841491-1841520	30	MN694177	Marine virus AFVG_250M361, complete genome	37138-37167	6	0.8
CP017428_2	2.1\|1841031\|29\|CP017428\|CRISPRCasFinder,CRT	1841031-1841059	29	NZ_LN774770	Lactococcus piscium MKFS47 plasmid II, complete sequence	47770-47798	7	0.759
CP017428_2	2.2\|1841096\|29\|CP017428\|CRISPRCasFinder,CRT	1841096-1841124	29	NZ_AP017915	Candidatus Azobacteroides pseudotrichonymphae plasmid pAPPJ1 DNA, complete sequence, phylotype ProJPt-1	13818-13846	7	0.759
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP053309	Spiroplasma citri strain C5 plasmid pScpC5-5, complete sequence	251-279	7	0.759
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NC_021795	Cellulophaga phage phi17:1, complete genome	3978-4006	7	0.759
CP017428_2	2.9\|1841555\|29\|CP017428\|CRISPRCasFinder,CRT	1841555-1841583	29	NC_014841	Pantoea sp. At-9b plasmid pPAT9B04, complete sequence	35538-35566	7	0.759
CP017428_2	2.9\|1841555\|29\|CP017428\|CRISPRCasFinder,CRT	1841555-1841583	29	MK250016	Prevotella phage Lak-A1, complete genome	257107-257135	7	0.759
CP017428_2	2.9\|1841555\|29\|CP017428\|CRISPRCasFinder,CRT	1841555-1841583	29	MK250019	Prevotella phage Lak-A2, complete genome	178241-178269	7	0.759
CP017428_2	2.9\|1841555\|29\|CP017428\|CRISPRCasFinder,CRT	1841555-1841583	29	AP014117	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C36-MedDCM-OCT-S25-C108, * SEQUENCING IN PROGRESS *	2493-2521	7	0.759
CP017428_2	2.10\|1841033\|29\|CP017428\|PILER-CR	1841033-1841061	29	NZ_LN774770	Lactococcus piscium MKFS47 plasmid II, complete sequence	47770-47798	7	0.759
CP017428_2	2.11\|1841098\|29\|CP017428\|PILER-CR	1841098-1841126	29	NZ_AP017915	Candidatus Azobacteroides pseudotrichonymphae plasmid pAPPJ1 DNA, complete sequence, phylotype ProJPt-1	13818-13846	7	0.759
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP053309	Spiroplasma citri strain C5 plasmid pScpC5-5, complete sequence	251-279	7	0.759
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NC_021795	Cellulophaga phage phi17:1, complete genome	3978-4006	7	0.759
CP017428_2	2.18\|1841557\|29\|CP017428\|PILER-CR	1841557-1841585	29	NC_014841	Pantoea sp. At-9b plasmid pPAT9B04, complete sequence	35538-35566	7	0.759
CP017428_2	2.18\|1841557\|29\|CP017428\|PILER-CR	1841557-1841585	29	MK250016	Prevotella phage Lak-A1, complete genome	257107-257135	7	0.759
CP017428_2	2.18\|1841557\|29\|CP017428\|PILER-CR	1841557-1841585	29	MK250019	Prevotella phage Lak-A2, complete genome	178241-178269	7	0.759
CP017428_2	2.18\|1841557\|29\|CP017428\|PILER-CR	1841557-1841585	29	AP014117	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C36-MedDCM-OCT-S25-C108, * SEQUENCING IN PROGRESS *	2493-2521	7	0.759
CP017428_1	1.2\|505025\|30\|CP017428\|PILER-CR,CRISPRCasFinder,CRT	505025-505054	30	NZ_CP023734	Escherichia coli strain FORC 064 plasmid pFORC64.3, complete sequence	36534-36563	8	0.733
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP035092	Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence	299736-299765	8	0.733
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NC_008688	Paracoccus denitrificans PD1222 plasmid 1, complete sequence	547084-547113	8	0.733
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	MN693083	Marine virus AFVG_25M55, complete genome	22884-22913	8	0.733
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NC_019736	Crinalium epipsammum PCC 9333 plasmid pCRI9333.05, complete sequence	21549-21577	8	0.724
CP017428_2	2.7\|1841424\|29\|CP017428\|CRISPRCasFinder,CRT	1841424-1841452	29	NZ_CP044980	Bacillus thuringiensis strain BT62 plasmid pBT62B, complete sequence	186874-186902	8	0.724
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NC_019736	Crinalium epipsammum PCC 9333 plasmid pCRI9333.05, complete sequence	21549-21577	8	0.724
CP017428_2	2.16\|1841426\|29\|CP017428\|PILER-CR	1841426-1841454	29	NZ_CP044980	Bacillus thuringiensis strain BT62 plasmid pBT62B, complete sequence	186874-186902	8	0.724
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP017764	Bacillus subtilis strain 29R7-12 plasmid unnamed1, complete sequence	3392-3421	10	0.667
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP032868	Bacillus subtilis subsp. subtilis strain N4-2 plasmid unnamed1, complete sequence	63468-63497	10	0.667
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP032864	Bacillus subtilis subsp. subtilis strain N2-2 plasmid unnamed1, complete sequence	12857-12886	10	0.667
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP032866	Bacillus subtilis subsp. subtilis strain N3-1 plasmid unnamed1, complete sequence	61706-61735	10	0.667
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP021893	Bacillus subtilis subsp. subtilis strain SRCM100333 plasmid pBS333 sequence	36543-36572	10	0.667
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP041370	Bacillus sp. M4U3P1 plasmid unnamed1, complete sequence	23094-23123	10	0.667
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP020024	Bacillus subtilis strain ATCC 21228 plasmid pLDW-15, complete sequence	50305-50334	10	0.667
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP032862	Bacillus subtilis subsp. subtilis strain N1-1 plasmid unnamed1, complete sequence	31925-31954	10	0.667
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP018185	Bacillus subtilis strain KH2 plasmid, complete sequence	30729-30758	10	0.667
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NC_015148	Bacillus subtilis subsp. natto plasmid pLS20 DNA, complete sequence, strain: IFO 3335	24963-24992	10	0.667
CP017428_1	1.9\|505486\|30\|CP017428\|CRT	505486-505515	30	NZ_CP014473	Bacillus subtilis subsp. natto strain CGMCC 2108 plasmid unnamed2, complete sequence	24963-24992	10	0.667

1. spacer 1.1|504960|29|CP017428|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP019752 (Staphylococcus aureus strain JRA307 plasmid pJRA307-1, complete sequence) position: , mismatch: 2, identity: 0.931

aacaccagaaaatatcacgaaagtaacaa	CRISPR spacer
aacacctgaaaatatcacgaaagtcacaa	Protospacer
****** ***************** ****

2. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_KM348008 (Bacillus pumilus strain 15.1 plasmid pBp15.1S, complete sequence) position: , mismatch: 4, identity: 0.862

tttttctgcccttttttataatttaattg	CRISPR spacer
gttttctgcccttttttatagttttatta	Protospacer
 *******************.*** ***.

3. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_KM348008 (Bacillus pumilus strain 15.1 plasmid pBp15.1S, complete sequence) position: , mismatch: 4, identity: 0.862

tttttctgcccttttttataatttaattg	CRISPR spacer
gttttctgcccttttttatagttttatta	Protospacer
 *******************.*** ***.

4. spacer 1.1|504960|29|CP017428|PILER-CR,CRISPRCasFinder,CRT matches to MT773554 (Myoviridae sp. isolate BML_2 genomic sequence) position: , mismatch: 5, identity: 0.828

aacaccagaaaatatcacgaaagtaacaa	CRISPR spacer
aacaccagaaaacatcaccaaagttccat	Protospacer
************.***** *****  **

5. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP013709 (Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
attttctgctcttttttattatttaaatc	Protospacer
 ********.********* ****** *

6. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP013844 (Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
attttctgctcttttttattatttaaatc	Protospacer
 ********.********* ****** *

7. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NC_021496 (Lactobacillus reuteri I5007 plasmid pLRI02, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
cttttgtgcccctttttataatttaacgg	Protospacer
.**** *****.**************. *

8. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to MG516911 (Proteus mirabilis plasmid pPm60, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

9. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP047114 (Proteus mirabilis strain SCBX1.1 plasmid plas1.1.2, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

10. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP053899 (Proteus mirabilis strain YPM35 plasmid pJPM35-1, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

11. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP053895 (Proteus mirabilis strain JPM24 plasmid pJPM24, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

12. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP047288 (Proteus cibarius strain G11 plasmid p152, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

13. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP053372 (Proteus cibarius strain G32 plasmid pG32-177, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

14. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP053043 (Proteus cibarius strain HNCF44W plasmid pHNCF44W_NDM-1, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

15. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP053897 (Providencia rettgeri strain YPR31 plasmid pYPR31, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

16. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP013709 (Clostridium botulinum strain F634 plasmid pRSJ2_2, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
attttctgctcttttttattatttaaatc	Protospacer
 ********.********* ****** *

17. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP013844 (Clostridium botulinum strain A634 plasmid pRSJ19_2, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
attttctgctcttttttattatttaaatc	Protospacer
 ********.********* ****** *

18. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NC_021496 (Lactobacillus reuteri I5007 plasmid pLRI02, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
cttttgtgcccctttttataatttaacgg	Protospacer
.**** *****.**************. *

19. spacer 2.16|1841426|29|CP017428|PILER-CR matches to MG516911 (Proteus mirabilis plasmid pPm60, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

20. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP047114 (Proteus mirabilis strain SCBX1.1 plasmid plas1.1.2, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

21. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP053899 (Proteus mirabilis strain YPM35 plasmid pJPM35-1, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

22. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP053895 (Proteus mirabilis strain JPM24 plasmid pJPM24, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

23. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP047288 (Proteus cibarius strain G11 plasmid p152, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

24. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP053372 (Proteus cibarius strain G32 plasmid pG32-177, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

25. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP053043 (Proteus cibarius strain HNCF44W plasmid pHNCF44W_NDM-1, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

26. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP053897 (Providencia rettgeri strain YPR31 plasmid pYPR31, complete sequence) position: , mismatch: 5, identity: 0.828

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctttccttttttataattttcttc	Protospacer
******* .***************  **

27. spacer 1.1|504960|29|CP017428|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP011248 (Agrobacterium tumefaciens strain Ach5 plasmid pAt, complete sequence) position: , mismatch: 6, identity: 0.793

aacaccagaaaatatcacgaaagtaacaa	CRISPR spacer
aaccccagaaaatatcacgatagacgcat	Protospacer
*** **************** **  .**

28. spacer 1.1|504960|29|CP017428|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032919 (Agrobacterium tumefaciens strain 15955 plasmid pAt15955, complete sequence) position: , mismatch: 6, identity: 0.793

aacaccagaaaatatcacgaaagtaacaa	CRISPR spacer
aaccccagaaaatatcacgatagacgcat	Protospacer
*** **************** **  .**

29. spacer 1.1|504960|29|CP017428|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033029 (Agrobacterium tumefaciens strain A6 plasmid pAtA6, complete sequence) position: , mismatch: 6, identity: 0.793

aacaccagaaaatatcacgaaagtaacaa	CRISPR spacer
aaccccagaaaatatcacgatagacgcat	Protospacer
*** **************** **  .**

30. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP045855 (Agrobacterium sp. MA01 plasmid punnamed1, complete sequence) position: , mismatch: 6, identity: 0.8

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
gttggcccaaacggaactggaactgcacct	Protospacer
..*..****** ****** ***********

31. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP014171 (Clostridium tyrobutyricum strain KCTC 5387 plasmid pCTK01, complete sequence) position: , mismatch: 6, identity: 0.793

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctgccctttttaataaccatatag	Protospacer
**************** ****..  ** *

32. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to CP016281 (Clostridium tyrobutyricum strain W428 plasmid pW428, complete sequence) position: , mismatch: 6, identity: 0.793

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctgccctttttaataaccatatag	Protospacer
**************** ****..  ** *

33. spacer 2.8|1841489|30|CP017428|CRISPRCasFinder,CRT matches to MN694376 (Marine virus AFVG_250M360, complete genome) position: , mismatch: 6, identity: 0.8

ctgatgtttcgtcattgcttgtcttgctgc	CRISPR spacer
ataatttttcgtcatggcttgtcttgtttc	Protospacer
 *.** ********* **********.* *

34. spacer 2.8|1841489|30|CP017428|CRISPRCasFinder,CRT matches to MN694177 (Marine virus AFVG_250M361, complete genome) position: , mismatch: 6, identity: 0.8

ctgatgtttcgtcattgcttgtcttgctgc	CRISPR spacer
ataatttttcgtcatggcttgtcttgtttc	Protospacer
 *.** ********* **********.* *

35. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP014171 (Clostridium tyrobutyricum strain KCTC 5387 plasmid pCTK01, complete sequence) position: , mismatch: 6, identity: 0.793

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctgccctttttaataaccatatag	Protospacer
**************** ****..  ** *

36. spacer 2.16|1841426|29|CP017428|PILER-CR matches to CP016281 (Clostridium tyrobutyricum strain W428 plasmid pW428, complete sequence) position: , mismatch: 6, identity: 0.793

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttctgccctttttaataaccatatag	Protospacer
**************** ****..  ** *

37. spacer 2.17|1841491|30|CP017428|PILER-CR matches to MN694376 (Marine virus AFVG_250M360, complete genome) position: , mismatch: 6, identity: 0.8

ctgatgtttcgtcattgcttgtcttgctgc	CRISPR spacer
ataatttttcgtcatggcttgtcttgtttc	Protospacer
 *.** ********* **********.* *

38. spacer 2.17|1841491|30|CP017428|PILER-CR matches to MN694177 (Marine virus AFVG_250M361, complete genome) position: , mismatch: 6, identity: 0.8

ctgatgtttcgtcattgcttgtcttgctgc	CRISPR spacer
ataatttttcgtcatggcttgtcttgtttc	Protospacer
 *.** ********* **********.* *

39. spacer 2.1|1841031|29|CP017428|CRISPRCasFinder,CRT matches to NZ_LN774770 (Lactococcus piscium MKFS47 plasmid II, complete sequence) position: , mismatch: 7, identity: 0.759

tttaagagcatgtagctatgatttggata	CRISPR spacer
tttaagagcatgttgttatgattgccttg	Protospacer
************* *.*******    *.

40. spacer 2.2|1841096|29|CP017428|CRISPRCasFinder,CRT matches to NZ_AP017915 (Candidatus Azobacteroides pseudotrichonymphae plasmid pAPPJ1 DNA, complete sequence, phylotype ProJPt-1) position: , mismatch: 7, identity: 0.759

acgatagttattaaacgatagttattaaa	CRISPR spacer
agattagttattaaatgatatttattatt	Protospacer
* . ***********.**** ******

41. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP053309 (Spiroplasma citri strain C5 plasmid pScpC5-5, complete sequence) position: , mismatch: 7, identity: 0.759

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttatgccgttttttataattttcaaa	Protospacer
***** **** *************    .

42. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NC_021795 (Cellulophaga phage phi17:1, complete genome) position: , mismatch: 7, identity: 0.759

tttttctgcccttttttataatttaattg	CRISPR spacer
cttttttgcccttttttataatagtacgg	Protospacer
.****.****************   *. *

43. spacer 2.9|1841555|29|CP017428|CRISPRCasFinder,CRT matches to NC_014841 (Pantoea sp. At-9b plasmid pPAT9B04, complete sequence) position: , mismatch: 7, identity: 0.759

ttaatcgtcgttttattatttattaaaca	CRISPR spacer
gtaatcgtcgttttatgatttttttattg	Protospacer
 *************** **** ** * ..

44. spacer 2.9|1841555|29|CP017428|CRISPRCasFinder,CRT matches to MK250016 (Prevotella phage Lak-A1, complete genome) position: , mismatch: 7, identity: 0.759

ttaatcgtcgttttattatttattaaaca	CRISPR spacer
atcaaattcgtttcattatttattaaact	Protospacer
 * *   ******.**************

45. spacer 2.9|1841555|29|CP017428|CRISPRCasFinder,CRT matches to MK250019 (Prevotella phage Lak-A2, complete genome) position: , mismatch: 7, identity: 0.759

ttaatcgtcgttttattatttattaaaca	CRISPR spacer
atcaaattcgtttcattatttattaaact	Protospacer
 * *   ******.**************

46. spacer 2.9|1841555|29|CP017428|CRISPRCasFinder,CRT matches to AP014117 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C36-MedDCM-OCT-S25-C108, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.759

ttaatcgtcgttttattatttattaaaca	CRISPR spacer
ataataatcgttttattatttattttgaa	Protospacer
 **** .*****************  . *

47. spacer 2.10|1841033|29|CP017428|PILER-CR matches to NZ_LN774770 (Lactococcus piscium MKFS47 plasmid II, complete sequence) position: , mismatch: 7, identity: 0.759

tttaagagcatgtagctatgatttggata	CRISPR spacer
tttaagagcatgttgttatgattgccttg	Protospacer
************* *.*******    *.

48. spacer 2.11|1841098|29|CP017428|PILER-CR matches to NZ_AP017915 (Candidatus Azobacteroides pseudotrichonymphae plasmid pAPPJ1 DNA, complete sequence, phylotype ProJPt-1) position: , mismatch: 7, identity: 0.759

acgatagttattaaacgatagttattaaa	CRISPR spacer
agattagttattaaatgatatttattatt	Protospacer
* . ***********.**** ******

49. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP053309 (Spiroplasma citri strain C5 plasmid pScpC5-5, complete sequence) position: , mismatch: 7, identity: 0.759

tttttctgcccttttttataatttaattg	CRISPR spacer
tttttatgccgttttttataattttcaaa	Protospacer
***** **** *************    .

50. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NC_021795 (Cellulophaga phage phi17:1, complete genome) position: , mismatch: 7, identity: 0.759

tttttctgcccttttttataatttaattg	CRISPR spacer
cttttttgcccttttttataatagtacgg	Protospacer
.****.****************   *. *

51. spacer 2.18|1841557|29|CP017428|PILER-CR matches to NC_014841 (Pantoea sp. At-9b plasmid pPAT9B04, complete sequence) position: , mismatch: 7, identity: 0.759

ttaatcgtcgttttattatttattaaaca	CRISPR spacer
gtaatcgtcgttttatgatttttttattg	Protospacer
 *************** **** ** * ..

52. spacer 2.18|1841557|29|CP017428|PILER-CR matches to MK250016 (Prevotella phage Lak-A1, complete genome) position: , mismatch: 7, identity: 0.759

ttaatcgtcgttttattatttattaaaca	CRISPR spacer
atcaaattcgtttcattatttattaaact	Protospacer
 * *   ******.**************

53. spacer 2.18|1841557|29|CP017428|PILER-CR matches to MK250019 (Prevotella phage Lak-A2, complete genome) position: , mismatch: 7, identity: 0.759

ttaatcgtcgttttattatttattaaaca	CRISPR spacer
atcaaattcgtttcattatttattaaact	Protospacer
 * *   ******.**************

54. spacer 2.18|1841557|29|CP017428|PILER-CR matches to AP014117 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C36-MedDCM-OCT-S25-C108, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.759

ttaatcgtcgttttattatttattaaaca	CRISPR spacer
ataataatcgttttattatttattttgaa	Protospacer
 **** .*****************  . *

55. spacer 1.2|505025|30|CP017428|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP023734 (Escherichia coli strain FORC 064 plasmid pFORC64.3, complete sequence) position: , mismatch: 8, identity: 0.733

ttatggcgttttgtgaaacagtgccgaatg	CRISPR spacer
tattattaatttgtgatacagtgccgaatg	Protospacer
*  *. .. ******* *************

56. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP035092 (Paracoccus denitrificans strain ATCC 19367 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.733

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
cggaacccaaaagcaacttgaattgctgtt	Protospacer
   ********** ********.***  .*

57. spacer 1.9|505486|30|CP017428|CRT matches to NC_008688 (Paracoccus denitrificans PD1222 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.733

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
cggaacccaaaagcaacttgaattgctgtt	Protospacer
   ********** ********.***  .*

58. spacer 1.9|505486|30|CP017428|CRT matches to MN693083 (Marine virus AFVG_25M55, complete genome) position: , mismatch: 8, identity: 0.733

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
actaacccaaaagcaccttgaacaaagttt	Protospacer
************* * ******* . ...*

59. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NC_019736 (Crinalium epipsammum PCC 9333 plasmid pCRI9333.05, complete sequence) position: , mismatch: 8, identity: 0.724

tttttctgcccttttttataatttaattg	CRISPR spacer
agattttgccctattttataatttaaagt	Protospacer
   **.****** *************

60. spacer 2.7|1841424|29|CP017428|CRISPRCasFinder,CRT matches to NZ_CP044980 (Bacillus thuringiensis strain BT62 plasmid pBT62B, complete sequence) position: , mismatch: 8, identity: 0.724

tttttctgcccttttttataatttaattg	CRISPR spacer
aacatctgcccctttttataatttacata	Protospacer
  . *******.*************  *.

61. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NC_019736 (Crinalium epipsammum PCC 9333 plasmid pCRI9333.05, complete sequence) position: , mismatch: 8, identity: 0.724

tttttctgcccttttttataatttaattg	CRISPR spacer
agattttgccctattttataatttaaagt	Protospacer
   **.****** *************

62. spacer 2.16|1841426|29|CP017428|PILER-CR matches to NZ_CP044980 (Bacillus thuringiensis strain BT62 plasmid pBT62B, complete sequence) position: , mismatch: 8, identity: 0.724

tttttctgcccttttttataatttaattg	CRISPR spacer
aacatctgcccctttttataatttacata	Protospacer
  . *******.*************  *.

63. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP017764 (Bacillus subtilis strain 29R7-12 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

64. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP032868 (Bacillus subtilis subsp. subtilis strain N4-2 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

65. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP032864 (Bacillus subtilis subsp. subtilis strain N2-2 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

66. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP032866 (Bacillus subtilis subsp. subtilis strain N3-1 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

67. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP021893 (Bacillus subtilis subsp. subtilis strain SRCM100333 plasmid pBS333 sequence) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

68. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP041370 (Bacillus sp. M4U3P1 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

69. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP020024 (Bacillus subtilis strain ATCC 21228 plasmid pLDW-15, complete sequence) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

70. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP032862 (Bacillus subtilis subsp. subtilis strain N1-1 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

71. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP018185 (Bacillus subtilis strain KH2 plasmid, complete sequence) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

72. spacer 1.9|505486|30|CP017428|CRT matches to NC_015148 (Bacillus subtilis subsp. natto plasmid pLS20 DNA, complete sequence, strain: IFO 3335) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

73. spacer 1.9|505486|30|CP017428|CRT matches to NZ_CP014473 (Bacillus subtilis subsp. natto strain CGMCC 2108 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.667

actaacccaaaaggaacttgaactgcacct	CRISPR spacer
ggctacccaagaggaacttgaactgtttga	Protospacer
. . ******.**************. .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1025774 : 1036151

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVO01729.1\|1025774_1026059_+	co-chaperone GroES	A0A221S4A8	uncultured_virus	1.8e-13	35.9
AVO01730.1\|1026097_1027717_+	chaperonin GroL	A0A240F779	uncultured_virus	3.8e-156	53.0
AVO01731.1\|1027780_1028956_-	recombinase	A0A1W6JPB2	Staphylococcus_phage	1.0e-150	66.9
AVO01732.1\|1028965_1029547_-	hypothetical protein	A0A0A8WFJ2	Clostridium_phage	2.3e-07	37.1
AVO01733.1\|1029640_1029859_+	hypothetical protein	NA	NA	NA	NA
AVO01734.1\|1029862_1030168_+	excisionase	A0A1W6JPE8	Staphylococcus_phage	1.1e-35	76.5
AVO01735.1\|1030169_1030373_+	pathogenicity island protein	A0A1W6JQF4	Staphylococcus_phage	7.5e-22	68.7
AVO01736.1\|1030375_1030798_+	hypothetical protein	NA	NA	NA	NA
AVO01737.1\|1030797_1031097_+	pathogenicity island protein	Q4ZE75	Staphylococcus_phage	9.4e-21	50.5
AVO01738.1\|1031199_1033539_+	DNA primase	A0A2H4JCU9	uncultured_Caudovirales_phage	6.0e-139	41.9
AVO01739.1\|1033922_1034189_+	hypothetical protein	H9A0M1	Staphylococcus_phage	1.8e-07	42.5
AVO01740.1\|1035584_1036151_+	peptidase U35	Q8SBP9	Clostridium_phage	5.2e-12	32.2

DBSCAN-SWA_2

1167026 : 1202880

Staphylococcus_phage(89.29%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVO01858.1\|1167026_1169069_-	copper-translocating P-type ATPase	E4ZFI9	Streptococcus_phage	1.1e-67	30.3
AVO01859.1\|1169329_1169842_-	hypothetical protein	NA	NA	NA	NA
AVO01860.1\|1170021_1170714_+	hypothetical protein	NA	NA	NA	NA
AVO01861.1\|1170829_1172218_+	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	5.9e-158	57.3
AVO01862.1\|1172220_1173231_+	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	5.5e-97	53.7
AVO01863.1\|1173221_1173479_-	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	4.7e-29	75.7
AVO01864.1\|1173556_1174048_+	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	4.9e-35	49.7
AVO01865.1\|1174013_1174787_+	dipeptidyl aminopeptidase	A0A2H4PQM6	Staphylococcus_phage	1.3e-93	66.5
AVO01866.1\|1174839_1176432_-	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	6.8e-259	81.4
AVO01867.1\|1176819_1178016_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	3.0e-187	81.6
AVO01868.1\|1178112_1179012_+	hypothetical protein	A0A2H4PQQ8	Staphylococcus_phage	4.0e-99	75.4
AVO01869.1\|1179133_1179970_+	glyoxal reductase	A0A2H4PQR8	Staphylococcus_phage	4.2e-103	63.8
AVO01870.1\|1180021_1180375_-	camphor resistance protein CrcB	NA	NA	NA	NA
AVO01871.1\|1180367_1180739_-	camphor resistance protein CrcB	A0A2H4PQR0	Staphylococcus_phage	6.1e-38	64.5
AVO01872.1\|1180799_1181108_-	hypothetical protein	NA	NA	NA	NA
AVO01873.1\|1181295_1182012_+	transaldolase	M1PR54	Cyanophage	3.8e-20	35.0
AVO01874.1\|1182152_1182614_+	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	1.4e-18	40.9
AVO01875.1\|1182588_1183029_-	hypothetical protein	NA	NA	NA	NA
AVO01876.1\|1183028_1183526_-	hypothetical protein	A0A2H4PQT5	Staphylococcus_phage	1.1e-21	42.5
AVO01877.1\|1183730_1183952_+	hypothetical protein	NA	NA	NA	NA
AVO01878.1\|1184125_1185442_+\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	1.4e-44	31.0
AVO01879.1\|1185838_1186684_+	autolysin	A0A1W6JNR1	Staphylococcus_phage	4.2e-42	41.7
AVO01880.1\|1186825_1188307_+	pyridine nucleotide-disulfide oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	1.0e-14	64.5
AVO01881.1\|1188701_1189751_+	riboflavin biosynthesis protein RibD	A0A2H4PQS8	Staphylococcus_phage	4.1e-119	59.9
AVO01882.1\|1189755_1190388_+	riboflavin synthase subunit alpha	A0A2H4PQS5	Staphylococcus_phage	2.8e-67	61.4
AVO01883.1\|1190403_1191585_+	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II	A0A2H4PQS2	Staphylococcus_phage	1.8e-168	73.5
AVO01884.1\|1191617_1192079_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	3.9e-58	75.2
AVO01885.1\|1192152_1193148_-	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	5.8e-115	63.3
AVO01886.1\|1193409_1194240_+	lysophospholipase	NA	NA	NA	NA
AVO01887.1\|1194416_1195373_+	L-lactate dehydrogenase	NA	NA	NA	NA
AVO01888.1\|1195438_1195996_-	16S rRNA (cytosine(1402)-N(4))-methyltransferase	A0A2H4PQV0	Staphylococcus_phage	3.5e-61	61.6
AVO01889.1\|1195992_1196955_-	TIGR01212 family radical SAM protein	A0A2H4PQV5	Staphylococcus_phage	4.3e-67	83.7
AVO01890.1\|1197227_1198406_+	multidrug MFS transporter	A0A2H4PQR6	Staphylococcus_phage	3.0e-163	73.2
AVO01891.1\|1198785_1201200_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	85.0
AVO01892.1\|1201220_1201538_+	sulfurtransferase	A0A2H4PQR9	Staphylococcus_phage	1.5e-32	66.7
AVO01893.1\|1201623_1202880_-	hypothetical protein	A0A2H4PQX1	Staphylococcus_phage	2.6e-40	75.0

DBSCAN-SWA_3

1332665 : 1342739

Klosneuvirus(33.33%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVO02004.1\|1332665_1334939_+	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	4.6e-75	30.9
AVO02005.1\|1334957_1335476_+	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	8.1e-28	44.4
AVO02006.1\|1335827_1338017_+	GTP pyrophosphokinase	A0A1B1IUF0	uncultured_Mediterranean_phage	9.0e-12	38.0
AVO02007.1\|1338032_1338485_+\|tRNA	D-tyrosyl-tRNA(Tyr) deacylase	NA	NA	NA	NA
AVO02008.1\|1338481_1339357_+	cell wall amidase	A0A0N9SGH1	Paenibacillus_phage	6.8e-11	33.1
AVO02009.1\|1339682_1340957_+\|tRNA	histidine--tRNA ligase	A0A2K9L6G5	Tupanvirus	2.3e-15	23.8
AVO02010.1\|1340972_1342739_+\|tRNA	aspartate--tRNA ligase	A0A1V0SIS0	Klosneuvirus	9.2e-07	33.7

DBSCAN-SWA_4

1640530 : 1679566

Staphylococcus_virus(38.64%)

terminase,integrase,portal

attL 1639620:1639642|attR 1679602:1679624

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
1639620:1639642	attL	NA	NA	NA	NA
AVO02293.1\|1640530_1641088_-	hypothetical protein	A0A0U4JD08	Gordonia_phage	1.2e-05	32.2
AVO03274.1\|1641504_1641690_-	hypothetical protein	A0A0F6N3H3	Staphylococcus_phage	1.4e-22	86.9
AVO02294.1\|1642397_1642940_-	hypothetical protein	NA	NA	NA	NA
AVO02295.1\|1643649_1645122_-	hypothetical protein	A0A2H4JAU4	uncultured_Caudovirales_phage	2.6e-220	71.8
AVO02296.1\|1645122_1645371_-	PTS mannose transporter subunit IID	Q4ZD59	Staphylococcus_phage	2.2e-36	87.8
AVO02297.1\|1645510_1645810_-	hypothetical protein	Q4ZD60	Staphylococcus_phage	6.3e-33	80.2
AVO02298.1\|1645866_1646145_-	hypothetical protein	A0A2H4J771	uncultured_Caudovirales_phage	7.6e-17	63.2
AVO02299.1\|1646150_1648019_-	hypothetical protein	A0A2H4JCH3	uncultured_Caudovirales_phage	4.6e-150	45.8
AVO02300.1\|1648035_1649688_-	hypothetical protein	A0A2P1JUJ3	Bacillus_phage	4.7e-45	36.3
AVO02301.1\|1649698_1650628_-	hypothetical protein	A0A2H4J5C4	uncultured_Caudovirales_phage	4.3e-48	59.6
AVO02302.1\|1650631_1654405_-	hypothetical protein	H9A0P1	Staphylococcus_phage	9.8e-115	65.0
AVO02303.1\|1654427_1654742_-	hypothetical protein	NA	NA	NA	NA
AVO02304.1\|1654774_1655233_-	hypothetical protein	NA	NA	NA	NA
AVO02305.1\|1655300_1655858_-	hypothetical protein	A0A1W6JQQ8	Staphylococcus_phage	5.1e-20	33.5
AVO02306.1\|1655871_1656342_-	hypothetical protein	A0A2H4PQL6	Staphylococcus_phage	3.5e-14	31.8
AVO02307.1\|1656356_1656740_-	hypothetical protein	M9NRJ3	Staphylococcus_phage	4.7e-25	46.3
AVO02308.1\|1656743_1657067_-	hypothetical protein	NA	NA	NA	NA
AVO02309.1\|1657056_1657377_-	hypothetical protein	NA	NA	NA	NA
AVO02310.1\|1657573_1658533_-	hypothetical protein	A0A097PAW2	Streptococcus_pyogenes_phage	1.1e-35	53.4
AVO02311.1\|1658547_1659117_-	hypothetical protein	I6SB44	Staphylococcus_virus	5.6e-22	45.2
AVO02312.1\|1659220_1660207_-	hypothetical protein	Q4ZC73	Staphylococcus_virus	9.5e-62	42.0
AVO02313.1\|1660175_1661576_-\|portal	phage portal protein	A0A1W6JQP9	Staphylococcus_phage	1.7e-125	49.9
AVO02314.1\|1661572_1662844_-\|terminase	terminase	Q4ZCF2	Staphylococcus_virus	2.4e-230	93.1
AVO02315.1\|1662843_1663221_-	DNA-binding protein	A0A1W6JP86	Staphylococcus_phage	6.7e-40	64.0
AVO02316.1\|1663299_1663845_-	hypothetical protein	NA	NA	NA	NA
AVO02317.1\|1664041_1664467_-	transcriptional regulator	A0A1J0MFW0	Staphylococcus_phage	2.3e-57	80.9
AVO02318.1\|1664593_1664770_-	transcriptional regulator	Q4ZC79	Staphylococcus_virus	2.1e-20	87.9
AVO02319.1\|1664772_1665069_-	hypothetical protein	NA	NA	NA	NA
AVO02320.1\|1665613_1665841_-	hypothetical protein	Q4ZC83	Staphylococcus_virus	3.6e-17	71.6
AVO02321.1\|1665837_1666098_-	hypothetical protein	NA	NA	NA	NA
AVO02322.1\|1666555_1666975_-	hypothetical protein	Q4ZC89	Staphylococcus_virus	7.7e-21	60.0
AVO02323.1\|1666975_1667491_-	hypothetical protein	Q4ZC91	Staphylococcus_virus	3.6e-12	30.8
AVO02324.1\|1667503_1667695_-	hypothetical protein	Q4ZC92	Staphylococcus_virus	6.6e-28	98.4
AVO02325.1\|1667695_1668103_-	Holliday junction resolvase	Q4ZC94	Staphylococcus_virus	6.9e-67	91.9
AVO02326.1\|1668086_1668275_-	hypothetical protein	Q4ZC95	Staphylococcus_virus	7.2e-27	95.2
AVO02327.1\|1668268_1669042_-	DNA replication protein DnaC	A0A1W6JP70	Staphylococcus_phage	6.0e-104	79.2
AVO02328.1\|1669054_1669792_-	replication protein	Q4ZDQ6	Staphylococcus_virus	9.0e-65	65.4
AVO02329.1\|1669837_1670320_+	hypothetical protein	A0A2H4JC39	uncultured_Caudovirales_phage	9.4e-47	61.9
AVO02330.1\|1670335_1671007_-	hypothetical protein	Q4ZC99	Staphylococcus_virus	4.7e-113	86.0
AVO02331.1\|1671019_1671466_-	single-stranded DNA-binding protein	A0A1J0MFD7	Staphylococcus_phage	3.1e-52	90.2
AVO02332.1\|1671465_1672137_-	single-stranded DNA-binding protein	A0A1J0MF78	Staphylococcus_phage	8.4e-110	89.5
AVO02333.1\|1672099_1672354_-	hypothetical protein	Q4ZCA2	Staphylococcus_virus	6.1e-37	96.4
AVO02334.1\|1672346_1672571_-	hypothetical protein	NA	NA	NA	NA
AVO02335.1\|1672670_1672886_-	hypothetical protein	Q4ZCA4	Staphylococcus_virus	3.3e-28	90.1
AVO02336.1\|1672898_1673201_-	hypothetical protein	Q4ZCA6	Staphylococcus_virus	6.7e-51	98.0
AVO02337.1\|1673315_1673639_+	hypothetical protein	NA	NA	NA	NA
AVO02338.1\|1673832_1674060_-	hypothetical protein	A0A0F6N4M2	Staphylococcus_phage	2.0e-23	71.6
AVO02339.1\|1674060_1674834_-	phage antirepressor	Q4ZCB0	Staphylococcus_virus	1.5e-142	99.2
AVO02340.1\|1674949_1675186_+	hypothetical protein	Q4ZBN3	Staphylococcus_phage	6.0e-31	84.6
AVO02341.1\|1675354_1675594_-	transcriptional regulator	A0A2H4J9X2	uncultured_Caudovirales_phage	3.9e-38	94.9
AVO02342.1\|1675786_1676119_+	transcriptional regulator	A0A2H4JC44	uncultured_Caudovirales_phage	1.0e-47	94.5
AVO02343.1\|1676132_1676606_+	toxin	A0A2H4J4F2	uncultured_Caudovirales_phage	1.1e-55	65.4
AVO02344.1\|1676610_1677234_+	hypothetical protein	NA	NA	NA	NA
AVO02345.1\|1677647_1678163_+	hypothetical protein	A0A0H3U494	Staphylococcus_phage	3.5e-39	48.0
AVO02346.1\|1678164_1678473_+	hypothetical protein	NA	NA	NA	NA
AVO02347.1\|1678537_1679566_+\|integrase	integrase	Q4ZCC1	Staphylococcus_virus	5.1e-191	98.8
1679602:1679624	attR	NA	NA	NA	NA

DBSCAN-SWA_5

1952199 : 1960621

Prochlorococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVO02598.1\|1952199_1952766_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.6e-32	40.3
AVO02599.1\|1952762_1953803_-	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	1.6e-70	44.1
AVO02600.1\|1953807_1955229_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	5.6e-47	30.8
AVO02601.1\|1955207_1957397_-	phosphoribosylformylglycinamidine synthase II	A6N228	Microbacterium_phage	7.4e-139	39.4
AVO02602.1\|1957389_1958061_-	phosphoribosylformylglycinamidine synthase I	NA	NA	NA	NA
AVO02603.1\|1958060_1958321_-	phosphoribosylformylglycinamidine synthase, purS protein	NA	NA	NA	NA
AVO02604.1\|1958320_1959025_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	E3SPA9	Prochlorococcus_phage	1.1e-48	42.9
AVO02605.1\|1959024_1960152_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
AVO02606.1\|1960138_1960621_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	4.7e-22	44.7

DBSCAN-SWA_6

2201680 : 2235670

Staphylococcus_phage(27.78%)

tail,transposase,capsid,portal,head,integrase,terminase

attL 2193505:2193521|attR 2231263:2231279

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2193505:2193521	attL	NA	NA	NA	NA
AVO02806.1\|2201680_2201989_-\|head,tail	phage head-tail adapter protein	NA	NA	NA	NA
AVO02807.1\|2202168_2203812_-\|terminase	terminase	A0A290GJW3	Caldibacillus_phage	1.0e-156	50.8
AVO02808.1\|2203804_2204125_-	hypothetical protein	NA	NA	NA	NA
AVO02809.1\|2204259_2204553_-	HNH endonuclease	R9TNN2	Paenibacillus_phage	7.3e-18	43.8
AVO02810.1\|2204545_2204827_-	DNA packaging protein	NA	NA	NA	NA
AVO02811.1\|2204892_2206125_-\|capsid	phage capsid protein	NA	NA	NA	NA
AVO02812.1\|2206126_2206693_-	peptidase U35	Q8SBP9	Clostridium_phage	2.3e-12	33.8
AVO02813.1\|2206679_2207888_-\|portal	phage portal protein	A0A1L2BY94	Clostridium_phage	1.2e-58	35.0
AVO02814.1\|2208085_2208427_-	pathogenicity island protein	A0A1W6JQD5	Staphylococcus_phage	2.2e-42	70.5
AVO02815.1\|2208675_2210175_-	virulence-associated protein E	A0A1W6JQD6	Staphylococcus_phage	3.0e-216	73.5
AVO02816.1\|2210171_2211092_-	hypothetical protein	A0A1W6JQL5	Staphylococcus_phage	3.0e-57	42.6
AVO02817.1\|2211135_2211411_-	pathogenicity island protein	A0A1W6JPG5	Staphylococcus_phage	4.0e-18	51.6
AVO02818.1\|2211410_2211704_-	hypothetical protein	NA	NA	NA	NA
AVO02819.1\|2211706_2211910_-	pathogenicity island protein	A0A2H4JD47	uncultured_Caudovirales_phage	1.1e-20	74.6
AVO02820.1\|2211926_2212172_-	hypothetical protein	NA	NA	NA	NA
AVO02821.1\|2212175_2212394_-	transcriptional regulator	A0A2H4JB11	uncultured_Caudovirales_phage	2.3e-13	54.2
AVO02822.1\|2212556_2213258_+	hypothetical protein	A0A2H4JH10	uncultured_Caudovirales_phage	3.2e-51	51.7
AVO02823.1\|2213277_2214336_+\|integrase	integrase	A0A1W6JQE7	Staphylococcus_phage	1.7e-64	42.7
AVO02824.1\|2215188_2215371_-	hypothetical protein	NA	NA	NA	NA
AVO02825.1\|2215884_2217198_+	branched-chain amino acid transport system II carrier protein	NA	NA	NA	NA
AVO02826.1\|2217453_2218638_+	MFS transporter	NA	NA	NA	NA
AVO02827.1\|2218692_2219637_-	DNA-binding protein WhiA	Q7AWZ3	Streptococcus_phage	5.9e-53	40.6
AVO02828.1\|2219655_2220654_-	hypothetical protein	A1IMD5	Streptococcus_phage	3.4e-51	41.8
AVO02829.1\|2220640_2221564_-	RNase adaptor protein RapZ	A0A0R8VB27	Thermobifida_phage	8.8e-09	30.3
AVO02830.1\|2221729_2222686_-	thioredoxin-disulfide reductase	G3MA85	Bacillus_virus	7.3e-83	49.5
AVO02831.1\|2222792_2224232_-	hypothetical protein	NA	NA	NA	NA
AVO02832.1\|2224252_2224735_-	acetyltransferase	NA	NA	NA	NA
AVO02833.1\|2224746_2225574_-	prolipoprotein diacylglyceryl transferase	NA	NA	NA	NA
AVO02834.1\|2225579_2226512_-	HPr kinase/phosphorylase	NA	NA	NA	NA
AVO02835.1\|2226700_2229550_-	excinuclease ABC subunit A	A0A1B1IVR3	uncultured_Mediterranean_phage	6.3e-311	56.9
AVO02836.1\|2229560_2231543_-	excinuclease ABC subunit B	NA	NA	NA	NA
2231263:2231279	attR	NA	NA	NA	NA
AVO02837.1\|2231872_2232115_-	protein CsbA	NA	NA	NA	NA
AVO02838.1\|2232121_2232763_-	hydrolase	NA	NA	NA	NA
AVO02839.1\|2233091_2234027_-	LysM family protein	NA	NA	NA	NA
AVO02840.1\|2234353_2235670_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	1.4e-44	31.0

DBSCAN-SWA_7

2258721 : 2271201

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AVO03297.1\|2258721_2259690_-	iron ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	7.8e-133	78.4
AVO02861.1\|2259995_2260970_-	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	2.1e-170	90.7
AVO02862.1\|2261082_2263188_-	ribonucleotide-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	88.2
AVO02863.1\|2263150_2263552_-	protein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.8e-43	65.4
AVO02864.1\|2264436_2265324_+	hypothetical protein	NA	NA	NA	NA
AVO02865.1\|2265326_2265830_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	6.6e-51	70.1
AVO02866.1\|2266012_2267536_+	peptide transporter	A0A0P0IY73	Acinetobacter_phage	7.1e-72	37.7
AVO02867.1\|2267830_2269333_+	peptide ABC transporter permease	A0A0P0IY73	Acinetobacter_phage	3.0e-67	34.3
AVO02868.1\|2269458_2269995_-	5'(3')-deoxyribonucleotidase	NA	NA	NA	NA
AVO02869.1\|2270136_2271201_-	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	2.2e-19	25.2

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP017429

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. CP017428

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection