CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP028158	Plantactinospora sp. BC1 chromosome, complete genome	15 crisprs	WYL,csa3,DinG,DEDDh,cas3,c2c9_V-U4	1	6	0	0

Cas Category Instructions

Results visualization

1. CP028158

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CRISPR-Cas detection and classification

Crispr_ID: CP028158_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_1

131616-131731

Orphan

Consensus_repeat	Method
GGCGTGGCGCTGGCTGGCGTGGCGGT	CRISPRCasFinder

2 spacers

The CRISPR arrays of CP028158_1

>merge|CP028158|1|131616-131731|CRISPRCasFinder
GCGGTGGCGGTGCCCGGCGGGGTAGTGCTCGACGGGGTAGTGCTCGGCGTGGCGCTGGCTGGCGTGGCGGTGGCTGGCGTGGCGGTGGCTGGCGTGGCGGTGGCTGGCGTGGCGGT

>CP028158|1|1|131616-131731|CRISPRCasFinder
GCGGTGGCGGTGCCCGGCGGGGTAGT	GCTCGACGGGGTAGTGCTC
GGCGTGGCGCTGGCTGGCGTGGCGGT	GGCTGGCGTGGCGGTGGCT
GGCGTGGCGGTGGCTGGCGTGGCGGT

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT28231.1\|121110_124224_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
CP028158.1\|AVT28240.1\|140747_142376_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|271154
CP028158.1\|AVT28241.1\|142382_143186_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379326
CP028158.1\|AVT28236.1\|135651_137010_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366154
CP028158.1\|AVT28225.1\|114626_115004_-\|sterol-binding-protein	unknown	unknown	unknown
CP028158.1\|AVT28229.1\|119305_120733_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143456
CP028158.1\|AVT28238.1\|138444_139506_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275164
CP028158.1\|AVT28237.1\|137011_138448_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380462
CP028158.1\|AVT28239.1\|139486_140476_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240139
CP028158.1\|AVT28235.1\|135184_135574_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT28227.1\|117446_118268_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
CP028158.1\|AVT28226.1\|115464_116220_+\|NmrA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|187554
CP028158.1\|AVT28232.1\|124220_125930_-\|AMP-dependent-synthetase	unknown	unknown	gnl\|CDD\|223395
CP028158.1\|AVT28243.1\|144346_144721_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|259885
CP028158.1\|AVT28230.1\|120778_121030_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223314
CP028158.1\|AVT28228.1\|118279_119116_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|375319
CP028158.1\|AVT28242.1\|143505_144303_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377255
CP028158.1\|AVT28234.1\|131826_134913_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
CP028158.1\|AVT34039.1\|125926_131578_-\|non-ribosomal-peptide-synthetase	unknown	unknown	gnl\|CDD\|237108
CP028158.1\|AVT34038.1\|116486_117341_+\|RNA-polymerase-subunit-sigma-24	unknown	unknown	gnl\|CDD\|132002

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT28231.1\|121110_124224_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
CP028158.1\|AVT28240.1\|140747_142376_-\|hypothetical-protein	gnl\|CDD\|271154	cd14488, CBM6-CBM35-CBM36_like_2, uncharacterized members of the carbohydrate binding module 6 (CBM6) and CBM35_like superfamily. Carbohydrate binding module family 6 (CBM6, family 6 CBM), also known as cellulose binding domain family VI (CBD VI), and related CBMs (CBM35 and CBM36). These are non-catalytic carbohydrate binding domains found in a range of enzymes that display activities against a diverse range of carbohydrate targets, including mannan, xylan, beta-glucans, cellulose, agarose, and arabinans. These domains facilitate the strong binding of the appended catalytic modules to their dedicated, insoluble substrates. Many of these CBMs are associated with glycoside hydrolase (GH) domains. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold. CBM36s are calcium-dependent xylan binding domains. CBM35s display conserved specificity through extensive sequence similarity, but divergent function through their appended catalytic modules.	4.30928e-46
CP028158.1\|AVT28241.1\|142382_143186_+\|hypothetical-protein	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.75489e-07
CP028158.1\|AVT28236.1\|135651_137010_-\|hypothetical-protein	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	1.4115e-27
CP028158.1\|AVT28229.1\|119305_120733_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143456	cd07138, ALDH_CddD_SSP0762, Rhodococcus ruber 6-oxolauric acid dehydrogenase-like. The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid, and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and other similar sequences, are included in this CD.	0
CP028158.1\|AVT28238.1\|138444_139506_-\|hypothetical-protein	gnl\|CDD\|275164	TIGR04371, conserved_hypothetical_protein, putative sugar O-methyltransferase. Members of this family appear to be SAM-dependent O-methyltransferases acting on sugars, based on iterated sequence searches and gene context. Members occur in Leptospira O-antigen regions, as well NanM from the biosynthesis cluster for nanchangmycin, which produces 4-O-methyl-L-rhodinose as an intermediate. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	3.40182e-14
CP028158.1\|AVT28237.1\|137011_138448_-\|hypothetical-protein	gnl\|CDD\|380462	cd19539, SgcC5_NRPS-like, SgcC5 is a non-ribosomal peptide synthetase (NRPS) condensation enzyme with ester- and amide- bond forming activity and similar C-domains of modular NRPSs. SgcC5 is a free-standing NRPS condensation enzyme (rather than a modular NRPS), which catalyzes the condensation between the SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and (R)-1phenyl-1,2-ethanediol, forming an ester bond, during the synthesis of the chromoprotein enediyne antitumor antibiotic C-1027. It has some acceptor substrate promiscuity as it has been shown to also catalyze the formation of an amide bond between SgcC2-tethered (S)-3-chloro-5-hydroxy-beta-tyrosine and a mimic of the enediyne core acceptor substrate having an amine at its C-2 position. This subfamily also includes similar C-domains of modular NRPSs such as Penicillium chrysogenum N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase PCBAB. Condensation (C) domains of NRPSs normally catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the epimerization (E) domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.	1.12977e-29
CP028158.1\|AVT28239.1\|139486_140476_-\|hypothetical-protein	gnl\|CDD\|240139	cd05006, SIS_GmhA, Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).	2.4104e-43
CP028158.1\|AVT28243.1\|144346_144721_+\|hypothetical-protein	gnl\|CDD\|259885	cd04223, N2OR_C, The C-terminal cupredoxin domain of Nitrous-oxide reductase. Nitrous-oxide reductase participates in nitrogen metabolism and catalyzes the last step in dissimilatory nitrate reduction, the two-electron reduction of N2O to N2. It contains copper ions as cofactors in the form of a binuclear CuA center at the site of electron entry and a tetranuclear CuZ centre at the active site. The C-terminus of Nitrous-oxide reductase is a cupredoxin domain.	4.6194e-06
CP028158.1\|AVT28227.1\|117446_118268_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.36937e-39
CP028158.1\|AVT28226.1\|115464_116220_+\|NmrA-family-transcriptional-regulator	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.64944e-20
CP028158.1\|AVT28232.1\|124220_125930_-\|AMP-dependent-synthetase	gnl\|CDD\|223395	COG0318, CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	5.7779e-101
CP028158.1\|AVT28230.1\|120778_121030_-\|hypothetical-protein	gnl\|CDD\|223314	COG0236, AcpP, Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	0.00054442
CP028158.1\|AVT28228.1\|118279_119116_-\|transcriptional-regulator	gnl\|CDD\|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	4.24703e-38
CP028158.1\|AVT28242.1\|143505_144303_+\|hypothetical-protein	gnl\|CDD\|377255	pfam04234, CopC, CopC domain. CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm.	6.51105e-11
CP028158.1\|AVT28234.1\|131826_134913_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
CP028158.1\|AVT34039.1\|125926_131578_-\|non-ribosomal-peptide-synthetase	gnl\|CDD\|237108	PRK12467, PRK12467, peptide synthase; Provisional.	0
CP028158.1\|AVT34038.1\|116486_117341_+\|RNA-polymerase-subunit-sigma-24	gnl\|CDD\|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	3.77892e-103

>CP028158.1|AVT34039.1|125926_131578_-|non-ribosomal-peptide-synthetase
MLAARLRPAAAPAEVVPARPPGTTVPLSFAQERLWFMEQYAPGTAAYTVPVVLRLRGTLDATALEAALRTVAARHESLRMRFDATADGRPVLRIDDTVSIRLEVVEAAGADLAAREAWVRTAVQARLAEPFDLARGPLLRAALYAVDPDDHVLALTVHHIVCDGWSAELLVGEVLTLLAAAGDAGRGTPAAPLPPLRRQYGDYALWQRERQRQRLADGTRDRDVGYWRTRLSGVPPLELPTDRPRPAEPTFRGAPVGVHLDAGSTAALRRLALDHGATLFMVVLAAYAAVLARFARQHDFAVGSPQAGRSHAELEPMIGMFVNMLVTRVDTSGDPSFPELVARVRDTVLDGYAHQELPFEELVTELDVPRDVGRSPIFQVALSMRTPAAPSPVSPPSPGGANTALSVAPFVVEAVATRFDLELDLLAGETLSGAFVYRRDLFDAETVERIADTFVEFVHEVARDPDRPLHRLLALGGAAREEVLVTWNDTAADFPEQATLHELVQASAAATPEAPAVTFEGTTLSYRELAERANRVAHRLREHGAGPGRLVAVCAHRSPELVVALLGVLVSGAAYLPLDPDHPAERLGFMLADADPVAVLTAGAAATALPPTDRPVLALDDPADWAGAPGTAPEPLAGPDDPAYVIYTSGSTGQPKGVLNGHRGVVNRLHWMQRRYGLTATETVLQKTPAGFDVSVWEFFWPLLAGARLVLARPDGHRDAGYLRDLIVAEQVSTVHFVPSMLTVFLTEEGIGRCRSLRRIVCSGEELPVDLALRALAALPDTELHNLYGPTEAAIDVTAYHCTAEKLTGAARVPIGAPIDNIRVYVLDERGEPLPVGVPGELHLAGVGLAHGYLNRPELTAEKFGTGPDGERRYRTGDLARWRPDGTLDFLGRLDGQVKLRGLRIELGEIEVALRDQPGIRDAAVVVREESPGDRRLAAYLVGSAPVDVAALRLALKRRLPDYMVPAAFVELPELPLSPNGKLDRRRLPAPPRGRDLDAPYVAPETATEVLVAEVWAEVLDVPRVGLDDDFFDLGGHSLLAVQVVARLRRAAGAGVSVLDLFTHRTVRELARLVAAPPEQRGPRDLVHELTRPVPAAQRVRTLVCVPYGGGSAVVYQPLADALPAGHRLFSVAIPGHDIGLDEAALPFDELAERCTEEILAKVDGPLALYGHCGVGSALTVEIARRLEQRGRDLDAVYIGAIFPFARPRSRVWTALSRLTRMESLRSDRVYANWLTSMGVDMSDIEPGQARQIIRNMRRDSDSAEAYFTQLMHAGTERLRAPVITVAGERDPATEFYAERFTEWHFLTDRAAVVVLDEAGHFFLRWRADELAEIVTTVDSAVLAERTEPLTRPARGAEPTWWLHDTSRSADRVAPAGPQPSMGRFLVIALAQLVSILGSTLTDVALPLWVLKETGSLLNFALLAVAGLVPGLLVLPVAGAVVDRYSRRAVILCGDVGAGGTQLLLGVLLWTGSLQVWHIYPLIALLSVSLTFQRLAYNSAIAQLVPKQYLGHANGVVQMVTGVATIMMPLLSVALLAVIDLGGILVIDVLSYAAAIVIVLLVRFPRTLAWRRRESLTAEIREGLRLSWGHRGFRSLLLFFMSLNVFLSPLFMMLTPLVLAFAGIDQVAQVSVAGGVGAFLGGLAMSIWGGPRHRRLFTVLCCTLVLAGFCLVIGLRPTLWVIAVGAFGISMWLVLLNGVYTTIVQVKIPQRFHGRVFAINTVIAWSTLPIGWTLVGPVGSRLLEPLMAPDGGLAGTVGRVIGVGHGRGIGLLYLLLAVAIAAVALVAMRLPRIARFDDEVPDAQPDDQVGVEALRHRAAPAQPAETQPGAQPGTRCQAESDAQPGGTQPAGTQPAGAQPVGTQPGGVQPAGAQRAATERVTAR
>CP028158.1|AVT28232.1|124220_125930_-|AMP-dependent-synthetase
MSGTSAEGAAGAGRGVATGGGARRTVGRRPGGVGRVALTVPQLLAARAGTEPSHVAVSQGAASLDLGTWQARTQAIAAGLRAAGVRPGDRVGLLYGAQDWIGYACSYTGVLAAAAVAVPLSTRSAPAELAYMLDHSGATALLHGPTAKLPDVPIRLRWGPDDVAGLPDAELPGAELPGAELPGAALPDAELPGAAPTAGPRPGDPAQILYTSGTTGRPKGVTATHANLTHGCRLDPPLRALAHSRQFLHAFPIGTNAGQTMLFNALDAHAGMLVTARFGPDHFARLIERHGVGSVFVVPAMAIELLRSGALERYDLSSVVLLGSTAAVLPPAVATGLAAALPGATIVNYYTSTEAAPTQTSVVFEPDRPAALGRVVAGGALQVRDEAGRPCPAGVTGEVWLRAAGTARSYHDDPAATRRVFRDGWTRMGDVGYLDADGYLYLVDRESDVIKSGADKVSTVAVEAALHEHPEIVEAAVFGLPDPVLGTTPVAALVTTRPLRLAEVRGFLASRLAGHEQPSRIVHVDELPRNAGGKVVKQRLRALFDQPDPTPAHPSGCPPEAAPERTARP
>CP028158.1|AVT28231.1|121110_124224_-|non-ribosomal-peptide-synthetase
MTQAPNLLPAEPSGAHAPVVGAGPDGAGAVAGSPVEVPMTLAQQGVWFTERAGGASTAYLLAVALTVPEPVEPAVLDRAWAELTGRHPLLAATVTEVDGAALLTRTDPAPVAHRAVGAEALDSAVTAELAVGFGLTADPLARCVALRVDDGRTVVLVVGHHLVLDGGGKDVLVADLAEALAGRPLGDGSPAGLTAAVRAQADRIAEALPAARDFWSARPAPADEVLLPGLTGTPTAAEPATRLDLDWGGELDAALTAGAAALGVTRFEVLLTAVHVVLARYGNGTASVAVDLSTRSPQTAHELGMWVNELPVTVGVDLAAPFAELVRTVRAEARAVYRHREVPLGRALPGLPPRPAMAPVSVSYRRLAESASDVDWLLVPATVRSALHLHLVDAPGGLTGRMLVPARLLSVADAERIAGHLRTLLGAALAEPDRPVGDLDLLVPAELALLDRLNATARPRPASTVLDLVRAAAEASPDAVAVHADDGTLSYRELVAAAHRIGHGLRRHGVAAGDLVGLCPRRGVELVAGVLGILAAGAGYLPLDPGYPANRLEFIVGDAGVKLVLGHAEATAALGGVPVELLPLDGLAAFAGEPETPPTAIDPDGLGYVIYTSGSTGRPKGVEIGHPALLNLVTAMTELLGADPADRWLHQTTISFDISGLELFAPLCTGGRVVVAADATAREGAALGRLVRDAGITHVQATPSSWQLLLDAGWAGAPITALSGGEALPLPLARRLRPLVDRLVNVYGPTETTIWSTAAEIPADPSRVTIGGPIANTTLHVLDARLRPVPVGVPGELCIGGVGLARGYRGRPELTAERFVPDGTGRRRYRTGDRVRLGADRTVEFLGRADNQVKLRGHRIELGEVERSLLDAPGVVEAAVAVRDGELVAYLVGAGELAPVRAHVAGTLPRYMIPRDLRWLDRLPRTPAGKLDRAALPTPERTDGTPPATEVEPAGTPESVALTRIVAGIWQEVLRVDEIGPHDSLFDLGGHSLTIMQITARIRKALGVEVPFDVFFDTPTVDGVVSSIEELRQEEQE
>CP028158.1|AVT28230.1|120778_121030_-|hypothetical-protein
MTVSELHHDLAGLVVEASDGQISAADALAEPESLGLLGLTSLGYVRLIQAVEHRYGVVVEPDDDVSGLDTVPALADYLHSRGV
>CP028158.1|AVT28229.1|119305_120733_+|aldehyde-dehydrogenase-family-protein
MTGPTQNAPGHWIDGAWTPAGSSATISVSNPASGEIVAEVPAGTADDLDRAVAAARAALPGWAATPPAERAAVVRRIAEGLGTRAEEIAAAITAEMGSPLILSRTAQVGFPVAVAESFTSLAADFAWTEEIGNSLIVREPIGVVGAITPWNFPLQQIVSKLAPALVAGNTMVFKPSEIAPLTARILAEVTAGAGLPDGVFNVVYGTGPVVGEAISAHPGIDMISFTGSTRAGRRIAAVAAATVKRVALELGGKGANVILDDADLPTAVRTGLAMAFTNGGQVCGAWPRMLVPASRQDEVVALAVAAAREYVVGEPTDEATRIGPMASEAHRERVHGYIERGIADGARLVFGGPGRPEGLDRGAYLRPTIFADVDPYSVIAQEEIFGPVLTIIPYADEDEAVAIANGTVYGLTAGVFGEPEHALAVARRLHAGQVDVNGGHWNPLAPFGGYKQSGNGREFGRAGLEEFLETKSIQR
>CP028158.1|AVT28228.1|118279_119116_-|transcriptional-regulator
MDRVRLAEFLRSRREALQPEDVGLPRGQRRRRTGGLRREEVAALSDMSTDYYSRIEQQRGPRPSEQMLAAIARGLRLSLEERDHLFRLGGYPTPSRVRRAEHINPGMMRIFDGLGDAAAQVVSDLGETLRQTRLATALLGNETRHTGLARSLHYRWFTEPESRRIHPEEDHPGHSRLLAADLHRAYTRAGRDSRAGEIVDGLLARSPEFAELWREHPVTGPYCAAKRIQHPRLGLLELHCQVLLDPDQSQSLLVFTATPGSESAERLRLLSVVAGQGL
>CP028158.1|AVT28227.1|117446_118268_+|alpha/beta-hydrolase
MGFVTAKDGTEIYYKDWGSGPVVTFSHGWPLSADAWDGQLLFLVQQGFRVVAHDRRGHGRSGQASARNDMDGYADDLAAVLEALDLTDVTLVGHSTGGGEVARYIGRYGTGRVARAVLISAVPPIMVQTPDNPEGLPIDVFDGLRAKLFADRSQFYQELAQMFYGANRPGAQVSKGILDQFWLWSMQAGMKNAYESIKAFSETDFRDDLAKFDVPTLVMHGEDDQIVPVKDSARKTAQLIANAQEIYYPGAPHGLTATLQDQVNNDLLAFLRS
>CP028158.1|AVT34038.1|116486_117341_+|RNA-polymerase-subunit-sigma-24
MGDFQAVRGRLFGIAYRMLGSVGDAEDVVQDAWLRWQGTDRRSVRNPAAFLTTTTTRLAINAVTTARARRETYVGPWLPEPVDTSADPALGAERAEGLELGVLLLLEKLAPAERAAYVLREAFDYAHRQVAEVLGTTEANARQLLSRARRHLASTRSTPVGRAEHRRLVEAFRAAARGGDLAALERLLAADVIASSDGGGRVHASRKDLYGVARVTTLLDNVLRKYWSESVIRVVPANGTESLLVAAADGTPEALLALAATDRGVERLFLVLNPDKLRQFAARG
>CP028158.1|AVT28226.1|115464_116220_+|NmrA-family-transcriptional-regulator
MKIVVIGGSGLIGSKVVELLAAAGHQAVAASPRTGVNAVTGEGLAEALDGADAVVDVSNSPSFDPAAAREFFETSTRNLLAAEAAAGVGHHVALSVVGADRMPNVGYMGAKVAQEALVAAGPVPYSIVRATQFFEFLDAIADTGTDGDTVRLGPVLFQPIAADDVAATVADVALGAPVGGIVEVAGPERSRLDEVIRSVLRAQQDPRQVVTDPAAGYYGAEVAEDALVPLGEARTGRIRLAERRAVDGAGR
>CP028158.1|AVT28225.1|114626_115004_-|sterol-binding-protein
MTSPTEEYFAEFSRRGHERLLEKASGTVRFEVVQGLCTEHWYVRVDRGDVTVTRENIEADGVVRVGRELFDRAACGEANLMAALLRGEISAEGKVPLLLMFERLLPGPQAPSGHRMATSGEPPRR
>CP028158.1|AVT28234.1|131826_134913_-|non-ribosomal-peptide-synthetase
MAEHDRAPLTPAQRRLWFLDRLDPGDPAYTVSTTVLLRGDLDVERLVGALDTVIARHESLRTRFVESGGVPVQEVLAARPTPVRLVEVSSEDEARRAVEELIGRPFDLAEGHLIRVGLLRLDARRHVLCTAVHHIVGDGWSMNLLYRQVAEAYRGVEPAAPGLRYLDHARSAQAVDEAALGYWRTALARPPVLELPLDRPRPAVRTSAGVAVVRGCGAELWTSVQQAARHLRCTPFMLLMTVYQLTLAQASGQHDICVGTPVAGRDDVAAESVFGYFTRMLVLRGDLSGDVTLRDLVLRTRATCLAAFAHQEIPFEQLVADLDLPRDPGRNPLFQAAFTLHSTMDVSATGFEGFQGLTVEAFGEGSRRTVTDVAMDVFVSSTAINSRSDDVRMDILLTCSADLFDPATADELADRFGAVLRAVLADPDTPVRALPLVDEAARAELTRIGTGPVLADGPPLLARIAGAVDTTPEAIALVSGADQVSYRELWARAGELADALRAAGVRPGQLVGVNLPRGPDLVVALLATWRVGAGYLPVDPGLPPRRRAALVEQAAVAAVLTVEGLRPGSTAPTRVPDPGYVLFTSGSTGTPKPVLVGRAALAARVGWMIDAYRLTGTDRVVQFAEPSFDTHAEEIWPTLATGGTLVLLPDGAQSLPELLAADPAITVLDLPTAYWQELLGLVPDWPAALRLVILGGEQVDATAVARWRDRHGDRIRLTNTYGPTEATIIATAIDLGAADTARRPPIGRPVGGARAYLLDEAGRLVPRGAVGELCLAGAGLADGYLGRPDLTAERFRPDPYGGGRLYRTGDRARWRRDEPVLEFLGRLDRQLKIRGVRVEPGEVEAVLTGHPEVGQAVVTALGETLVGYVTGTSAVAEVRAHAAERLPAPLVPSVLVPLAALPLTPHGKVDTAALPVPSIVDEARVAFEAPRTDAEELVAGIFAELLPVDRVGAADDFFALGGHSLLAVRVIARLRAAVSLDLPVRLLFQHPTVAGFARAVEAALVAEIDRLTEDEAAAELAAARTGAP
>CP028158.1|AVT28235.1|135184_135574_+|hypothetical-protein
MRRRLQLRYVPRRHHPVGAEEREQPRPAQDPQRGPAFGDGADGHRDTPTSQPVHDFGHTAARHDLVDGTDQRREVPALRREHLGRRDPGAGQRRDLRRQPGVGAADEVREPVQRLVPAEHDADLPGGPQ
>CP028158.1|AVT28236.1|135651_137010_-|hypothetical-protein
MLSVIMPTYNQVSCLDLTLGSLARQTADRDRFEVIVVDDASVQDVRAVVRRHEADLRLRYVRHDTNRGRSAARNSGVARSRADLLLLMDADSYAAPDLVERHLRRSGGACVEVVYGRRIEPSWGTFARLRQAIPDEADLLPMEGDHRDLPGRAGGGFDVYRRTGWMFGFTHNLSLPRELYLQVGGFDEAFVQWGYEDTDFTYRIYRHFGRDSSRFRYDPDALCYHTPHFRDWATEWEKTKPVLPYLVEKYRHYDVEFFTHPSDNHRRVARTLPFYEECREFVRDHPARVTGDAVRKAVGLPDAASSLWIGYDVGTAASAGRITGIDHAVAYGPENPHLFGVRTPYPDGSFDYVVHLDLWRMLTPIDLSALILDSLRIAGVALLVLSKGLRRDPADGIGMLDDLDYLLDMLTPRYSAVISYQDDEMAVVRLTHPGSATAAPPDLGSAPPGGRR
>CP028158.1|AVT28237.1|137011_138448_-|hypothetical-protein
MTGDGTADAPRRERSTLEFTGLDGGSAELTWGQRFVWDILESLAPANHYLNIRFRVHLPGDVTRERVLTALHTLVGRHEALRTRFTVDPDGEPRQHCDRAGDLPVEICETEPGRVRRVAEQAEERLWRQPFRHDDEWPLRVSLVAAGGRPRQVVFVLSHLAADSWGCFVLRREFLDLLRDDRAAPAAGWQPLARAGYEASASGRRTNELALAYWRRVLESMPPTAFPGPPGPGGSPLFPGVGLHSVALAAAVRAVSVRHRVGPAAVLLGALATIIGVRTGTREVPLFLAGGNRFTPGDAASVGTFYQGAPALIKVDGGSLAGTLRAAHRASTLAYLRGQSDPRDVARLLAEVQTRRGVDIDLASTVNVVPEPGVAGPPPAPLGVAELRELTAATVVSELEGRESERLTLYLHVRSLRSRAVLELFADSRRLPAADAGRLLAGLELVLIELLDAGDLDVDRVADLVGIATPTLHAHRGA
>CP028158.1|AVT28238.1|138444_139506_-|hypothetical-protein
MNHVSSRLFLTVRYLVGLFGLTLTRTSTEITSYRIHAGHGRYDDSRPLPAELAALLHDRNPDLVQLRRRYRELASPFRPGRFWRRSRRLRDLDLRYFRGDNAYVWQLRQLGDNARLKFFLFARYVSSLDTHKLLDRTTEDGAFGCWTFDFESLPTASRDLLDSINEIYFLDRHWGLLSRTDFTVVDIGAGYGRLAHRMVESVPGLKRYLCVDAIPESTFLSEHYLRHRRVEPKAVVLRLDEMAERLAAERPDLAVNVHSFSEMPIAAIEAWIDLLARCGVPTLLIVPNEGDRLLSLEDDYLRRDFAPVLARHGYVLAAREPTIADPDVRELVGAGDWFLLYRRVGTDPTAEAS
>CP028158.1|AVT28239.1|139486_140476_-|hypothetical-protein
MPRPAPGRTIAGLPYPSMVVIFHTGHGGTATWRSAAVCHRPRTTCRGGACVGRTIGGHNCAAHPGTGSPAVIRKQHRMRCVRAIRALPRRRIPMTVHPGERLDPAAGPVPAPTGAETVVKQYVDDLTLALAQLETGSVTDLLETLVLTLHSGRRVFVAGNGGSSTAAIHIASDLMAAAGTLGGAPQVVALTENIARITAIANDHCYDEIFSRQLTGWGRPRDALLLLSVSGHSTNLVRAARVGRDLGMTVLAALGNAGEVARLADRLVVFGQADYGLTEDLHVALGHMAVRVLRGGDACRFSAAAADDGPAGAGAEREKVGERGEPRQF
>CP028158.1|AVT28240.1|140747_142376_-|hypothetical-protein
MTISFAPSRSGPHRSPVPTPARTGDAMRRSALAVPLAALVAFVGIGAANPVPAVAVAADPDIGTLASTSLAPGLSLSTASTSGPNQVNVLTANLSEPTLKPKYLSPGTVGATATLTTQANRVGAVAAVNGDFFDIGATGAPRGVGLDDGTMLHGPASGWNNVAALYANGTGTRGGLAQIFLDARITLPGGAQLTATNLNSPNIAADGIGVYNALWGDEPRSQALDGATRSREVEITGGRVSRVSTTAGGKVSAGSVVLLGVNAGADALAGIAVGDTVTVDYSPRGAAGATQVAIGGNLVLVRDGVATTVAHPRNPRTAVGFSADGLTMWMVVVDGRSGTSVGMTYVELANYMKSLGADDAINLDGGGSSTMVARMPGATSVSVRNTPSDGAQRPVPNGIGFVSTAQAWSSTVDNSTAGRFTASANWGTSSYSSSRFGTDYRFADPVLSSDVAWYRVNVPETASYAVAVWYPADPGYNDSTPFIVATTSGNQTVRVNQRANGGRWVSLGVFTLPSGDANRVGVSRWTSGTGYVVADAVRITRV
>CP028158.1|AVT28241.1|142382_143186_+|hypothetical-protein
MLRWQEAPPPRPGGRGIARLPRMIGPDAYVENAAAMWSAVALHTRRDQSCFRAELPRATRLILRAPLSTEGVSGLLDSVPPAKSAVVEDVFGGGAAEPADPAVRVLRMPVMVRPAGTVGTTSDGDVRIVCVSDPAELAVAERTMVEGFPLPAFLPWRSGEALPAAVLTVPGWSVRLAYRRGEPAAATYTYDDGRVVGLYWLVTSPSHRSAGLGRALLTQAIAAHPDRPFTLVATDAGRPLYESLGFRTVATTGWYLRAPVPAPDPHR
>CP028158.1|AVT28242.1|143505_144303_+|hypothetical-protein
MGRAAPRLLAAVLLGLLTVPLGAVASRPAYAHGQLAVSTPADGATLSAPVESVSLAFTEQPAPFAYFTVTAPNGSRVDRRWSTGAPIRLDEPVREYQLVNGAWEPRLFHVGFTVRVPVAYWPEQGRYVVRYQTVASDGEEVEGEVRFTYTGANTSAPAGWQAPTDQPSPELVAAAGHGRPTAPAPVPPSAPPSASAAPAAAPERGPGVSVWLVPAVLVVGAVVLIAGVARRPAGPGSASRSRAPTGGPTRRRAGPAPTPNRRKRR
>CP028158.1|AVT28243.1|144346_144721_+|hypothetical-protein
MPPHPRRHRSTHAAVALLALLLIGPTACGDGEPAATGTVETVTVTIAGGSVSPAPGRIEVTRGQTVRITTTSDVADMVHVHGYDRSVTLRPGVAGTVEFVADQDGLFEVETHGQDLQLFQLVVR

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Crispr_ID: CP028158_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_2

771282-771385

Orphan

Consensus_repeat	Method
AGCGGAGCGAGGCGGCGGCATGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_2

>merge|CP028158|2|771282-771385|CRISPRCasFinder
AGCGGAGCGAGGCGGCGGCATGAGCGAGCGTGGCGAGCGAATCATCAGACTCAGGGTGGTTGTGCCTCATGGCGGCGCCGAGCGGAGCGAGGCGGCGGCATGAG

>CP028158|2|2|771282-771385|CRISPRCasFinder
AGCGGAGCGAGGCGGCGGCATGAG	CGAGCGTGGCGAGCGAATCATCAGACTCAGGGTGGTTGTGCCTCATGGCGGCGCCG
AGCGGAGCGAGGCGGCGGCATGAG

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT28655.1\|772994_773210_+\|ubiquitin-like-protein-Pup	unknown	unknown	gnl\|CDD\|368536
CP028158.1\|AVT28661.1\|779864_780068_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT34121.1\|756806_757544_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225203
CP028158.1\|AVT28656.1\|773527_774367_+\|proteasome-subunit-beta	unknown	unknown	gnl\|CDD\|163402
CP028158.1\|AVT34122.1\|762574_763261_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107
CP028158.1\|AVT28653.1\|769307_771089_+\|proteasome-ATPase	unknown	unknown	gnl\|CDD\|200312
CP028158.1\|AVT28652.1\|768287_768860_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT28650.1\|763313_764576_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
CP028158.1\|AVT34123.1\|765806_767099_+\|peptidase-M50	unknown	unknown	gnl\|CDD\|100085
CP028158.1\|AVT34124.1\|775305_776226_-\|dTDP-4-dehydrorhamnose-reductase	unknown	unknown	gnl\|CDD\|367904
CP028158.1\|AVT28662.1\|780084_781167_-\|DUF3866-domain-containing-protein	unknown	unknown	gnl\|CDD\|379008
CP028158.1\|AVT28647.1\|757740_758394_+\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223710
CP028158.1\|AVT28651.1\|767095_768040_+\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|225317
CP028158.1\|AVT28660.1\|778478_779837_+\|Pup--protein-ligase	unknown	unknown	gnl\|CDD\|274725
CP028158.1\|AVT28659.1\|777483_778356_+\|glucose-1-phosphate-thymidylyltransferase	unknown	unknown	gnl\|CDD\|130274
CP028158.1\|AVT28648.1\|758527_761074_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226957
CP028158.1\|AVT28658.1\|776369_777386_-\|dTDP-glucose-4,6-dehydratase	unknown	unknown	gnl\|CDD\|187557
CP028158.1\|AVT28649.1\|761073_761841_-\|peptide-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|213222
CP028158.1\|AVT28663.1\|781185_782118_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
CP028158.1\|AVT28657.1\|774427_775285_+\|proteasome-subunit-alpha	unknown	unknown	gnl\|CDD\|163403

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT28655.1\|772994_773210_+\|ubiquitin-like-protein-Pup	gnl\|CDD\|368536	pfam05639, Pup, Pup-like protein. This family consists of several short bacterial proteins formely known as (DUF797). It was recently shown that Mycobacterium tuberculosis contains a small protein, Pup (Rv2111c), that is covalently conjugated to the e-NH2 groups of lysines on several target proteins (pupylation) such as the malonyl CoA acyl carrier protein (FabD). Pupylation of FabD was shown to result in its recruitment to the mycobacterial proteasome and subsequent degradation analogous to eukaryotic ubiquitin-conjugated proteins. Searches recovered Pup orthologs in all major actinobacteria lineages including the basal bifidobacteria and also sporadically in certain other bacterial lineages. The Pup proteins were all between 50-90 residues in length and a multiple alignment shows that they all contain a conserved motif with a G [EQ] signature at the C-terminus. Thus, all of them are suitable for conjugation via the terminal glutamate or the deamidated glutamine (as shown in the case of the Mycobacterium Pup). The conserved globular core of Pup is predicted to form a bihelical unit with the extreme C-terminal 6-7 residues forming a tail in the extended conformation. Thus, Pup is structurally unrelated to the ubiquitin fold and has convergently evolved the function of protein modifier.	7.99803e-19
CP028158.1\|AVT34121.1\|756806_757544_+\|hypothetical-protein	gnl\|CDD\|225203	COG2321, COG2321, Predicted metalloprotease [General function prediction only].	4.11908e-14
CP028158.1\|AVT28656.1\|773527_774367_+\|proteasome-subunit-beta	gnl\|CDD\|163402	TIGR03690, 20S_bact_beta, proteasome, beta subunit, bacterial type. Members of this family are the beta subunit of the 20S proteasome as found in Actinobacteria such as Mycobacterium, Rhodococcus, and Streptomyces. In Streptomyces, maturation during proteasome assembly was shown to remove a 53-amino acid propeptide. Most of the length of the propeptide is not included in this model. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	8.05109e-121
CP028158.1\|AVT34122.1\|762574_763261_-\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.72778e-71
CP028158.1\|AVT28653.1\|769307_771089_+\|proteasome-ATPase	gnl\|CDD\|200312	TIGR03689, pup_AAA, proteasome ATPase. In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
CP028158.1\|AVT28650.1\|763313_764576_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	4.87855e-46
CP028158.1\|AVT34123.1\|765806_767099_+\|peptidase-M50	gnl\|CDD\|100085	cd06164, S2P-M50_SpoIVFB_CBS, SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain. SpoIVFB is one of 4 proteins involved in endospore formation; the others are SpoIVFA (sporulation protein, stage IV cell wall formation, F locus, promoter-proximal A), BofA (bypass-of-forespore A), and SpoIVB (sporulation protein, stage IV cell wall formation, B locus). SpoIVFB is negatively regulated by SpoIVFA and BofA and activated by SpoIVB. It is thought that SpoIVFB, SpoIVFA, and BofA are located in the mother-cell membrane that surrounds the forespore and that SpoIVB is secreted from the forespore into the space between the two where it activates SpoIVFB. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown.	8.70226e-69
CP028158.1\|AVT34124.1\|775305_776226_-\|dTDP-4-dehydrorhamnose-reductase	gnl\|CDD\|367904	pfam04321, RmlD_sub_bind, RmlD substrate binding domain. L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesized by four different enzymes the final one of which is RmlD. The RmlD substrate binding domain is responsible for binding a sugar nucleotide.	3.24539e-108
CP028158.1\|AVT28662.1\|780084_781167_-\|DUF3866-domain-containing-protein	gnl\|CDD\|379008	pfam12982, DUF3866, Protein of unknown function (DUF3866). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 352 and 374 amino acids in length.	6.95632e-169
CP028158.1\|AVT28647.1\|757740_758394_+\|HAD-family-hydrolase	gnl\|CDD\|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	5.47232e-42
CP028158.1\|AVT28651.1\|767095_768040_+\|SAM-dependent-methyltransferase	gnl\|CDD\|225317	COG2519, GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis].	2.00755e-102
CP028158.1\|AVT28660.1\|778478_779837_+\|Pup--protein-ligase	gnl\|CDD\|274725	TIGR03686, pupylate_PafA, Pup--protein ligase. Members of this family are the Pup--protein ligase PafA (proteasome accessory factor A), a protein shown to regulate steady-state levels of certain proteasome targets in Mycobacterium tuberculosis. Iyer, et al (2008) first suggested that PafA is the ligase for Pup, a ubiquitin analog attached to an epsilon-amino group of a Lys side-chain to direct the target to the proteasome. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
CP028158.1\|AVT28659.1\|777483_778356_+\|glucose-1-phosphate-thymidylyltransferase	gnl\|CDD\|130274	TIGR01207, Glucose-1-phosphate_thymidylyltransferase_1, glucose-1-phosphate thymidylyltransferase, short form. Alternate name: dTDP-D-glucose synthase homotetramer This model describes a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases. It is well characterized in several species as the first of four enzymes involved in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	1.45537e-160
CP028158.1\|AVT28648.1\|758527_761074_-\|ABC-transporter-permease	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	5.19319e-21
CP028158.1\|AVT28658.1\|776369_777386_-\|dTDP-glucose-4,6-dehydratase	gnl\|CDD\|187557	cd05246, dTDP_GD_SDR_e, dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs. This subgroup contains dTDP-D-glucose 4,6-dehydratase and related proteins, members of the extended-SDR family, with the characteristic Rossmann fold core region, active site tetrad and NAD(P)-binding motif. dTDP-D-glucose 4,6-dehydratase is closely related to other sugar epimerases of the SDR family. dTDP-D-dlucose 4,6,-dehydratase catalyzes the second of four steps in the dTDP-L-rhamnose pathway (the dehydration of dTDP-D-glucose to dTDP-4-keto-6-deoxy-D-glucose) in the synthesis of L-rhamnose, a cell wall component of some pathogenic bacteria. In many gram negative bacteria, L-rhamnose is an important constituent of lipopoylsaccharide O-antigen. The larger N-terminal portion of dTDP-D-Glucose 4,6-dehydratase forms a Rossmann fold NAD-binding domain, while the C-terminus binds the sugar substrate. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	0
CP028158.1\|AVT28649.1\|761073_761841_-\|peptide-ABC-transporter-ATP-binding-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	2.96678e-105
CP028158.1\|AVT28663.1\|781185_782118_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.70252e-38
CP028158.1\|AVT28657.1\|774427_775285_+\|proteasome-subunit-alpha	gnl\|CDD\|163403	TIGR03691, 20S_bact_alpha, proteasome, alpha subunit, bacterial type. Members of this family are the alpha subunit of the 20S proteasome as found in Actinobacteria such as Mycobacterium, Rhodococcus, and Streptomyces. In most Actinobacteria (an exception is Propionibacterium acnes), the proteasome is accompanied by a system of tagging proteins for degradation with Pup. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	6.09127e-118

>CP028158.1|AVT28653.1|769307_771089_+|proteasome-ATPase
MARSDDADSRAARWEKEAHDLSTQVAFLQEELALVRRKLTESPRHVRQLEERLAATQAQLARLTENNERLVNTLKEARAQIVTLKEEIDRLAQPPSGYGVFLAKHDDGTVDVFTGGRKLRVAVSPSLDVAELRRGQEVLLNDALNIVDAFGYERVGEVVMLKEVLDSPSGGAGDRALVISHADEERIVHLAETLIGAPLRAGDSLMIEPRSAYAYERIPKSEVEELVLEEVPDVDYGDIGGLQAQIEQIRDAVELPFLHADLFREHQLRPPKGILLYGPPGCGKTLIAKAVANSLAKKIAERRGEEKHTSFFLNIKGPELLNKYVGETERHIRLIFQRAREKAGEGTPVIVFFDEMDSVFRTRGSGVSSDVENTIVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAKDIFSKYILTGLPLHPDDLAEHGNDPQSTVAAMIEAVVLRMYSETEENRFLEVTYANGDKEVLYFKDFNSGAMIQNIVDRGKKMAIKEFLSSGRKGLRLQHLLDACVDEFRENEDLPNTTNPDDWARISGKKGERIVYIRTLVSGGKGAEAGRSIETASNTGQYL
>CP028158.1|AVT28652.1|768287_768860_+|hypothetical-protein
MSRPAFGGGDLPAVFPDWSPYRDLESAARAYLRDPDVAMEALTGVLNGASVLGFTLERFVNEVNGVWQEVAICDGSRLILWHGEDVPPDDGPAGAMTSSLRVVPVSTVSEVGCRRRLSRTPTGQIRVDSIDVYLLLSSLDEGVPGDEAHVPPRHDALRFGKTLDDGGAGQISRLEEFARLVASVVGRPTL
>CP028158.1|AVT28651.1|767095_768040_+|SAM-dependent-methyltransferase
MTAQPTAVPAAPTAPVPAHRGPFRPGDRVQLTDPKGRMHTIKLEPGRSFHTHRGALEHDALIGLPDGSVVTSTGGTAYLALRPLLADYVLSMPRGAQVIYPKDAAQIVAMGDIFPGAKVLEAGVGSGALTCSLLRAVGPEGELHSYELREDFSEIARRNVESFFGGPHPAWNLRVGDVADCQESGFDRIILDLLTPWEALDMVERALVPGGVFIGYVATTPQLSELVEALRERGGFTEPRAWESLVRDWHADGLAVRPDHRMIAHTAFLVSSRRLAPGVTAPPRRRKPSKGAEAYALRRQARQEAEATSGRAGE
>CP028158.1|AVT34123.1|765806_767099_+|peptidase-M50
MSGRLCHGYDRTGPTRPGMRTGPDRPRSPRPNRRGHPEGCSVASEEMERNSRPRRGADRRPGVTVGRVFGVPVYLNPSMLLLVALITLMYGEFVRQQLGLSQLTGYLVGLVFVVLLLGSVLLHELGHALTARRFGIGVRGITLELLGGYTEMERDAPTPRVDLFVSLAGPAVSLVLGLVGVVATLALPDGTLANQFAFQLAASNVLVGLFNILPGLPLDGGRALRAGVWAVTRDRHLATEVAGWSGRVVAIGTAVVFTLLTWLAGLPWLGLALVLLVAFTLWQGAGQTIRAARISRRFPLVDLARLARPVFSVPSGTPLAEAQRRGADAGLPGSTLGVADSSGRLVALVDRTAAEAVPVERRPWVAVDAVARGVDAVPSLAVGLGGEQVVHAVQAHPGAQYLVTSGEDVVGVLHVADLAQLLEPNRKMTQ
>CP028158.1|AVT28650.1|763313_764576_-|sensor-histidine-kinase
MTPTDTPATPASSRIRGSWRRLRPDSRQRAWLARDGLLAVAAVAVETVLVGTAPPGLAPWGWPGWAFWSVLCAAPITLRRVAPWWAVLLAVPIFVGSALTGAQPVTAAATFVLLTYTTAALLPLRQAALAAGAIWGPAVAVALAEPPPPDFTEPSPAYLVFTQVLLALVCFFVGRTVHARRATILALEERARVAEENQRSLADQAVADERRRIARELHDVVAHHVSVMGVLATGARRVLSRDPTATDGALGTIEETSRTTLRELRRLLDVLRTDAEPAAELSPQPGLAGIEALVEQVREAGLPVTLRVDGTPGPLDPGVALTVFRIVQEALTNTLKHAGAATAQVRLSFGVYWLIVEVADTGRGPAPEGGRLGHGLVGMRERMALYGGTLRTGPRPGGGYRVYAKMPMEQLGAPISKGAA
>CP028158.1|AVT34122.1|762574_763261_-|DNA-binding-response-regulator
MSDGRESSRPVRVLLADDQPLLRTGFRMVLGAEDDLDIVGEAGDGVEAVDLSRRLLPDVVLMDIRMPRMDGVAATRAIIDARLPVRVLILTTFDLDEYVVGALRAGASGFLAKDVPAEDLVTAIRTVAAGEAVVAPRILKRLLDRFAETLPDPDATPPKAIGVLTEREREVLVQVARGLSNAEIARVLSVSETTIKTHVGHVLTKLGLRDRVQAVVLAYETGLVRPGA
>CP028158.1|AVT28649.1|761073_761841_-|peptide-ABC-transporter-ATP-binding-protein
MTATLARDAQMAARANDVWKVYGSGEAQVVALRGVNAEFERARFTAIMGPSGSGKSTLMHCLAGLDSVTRGTIHIGDTAVTGLGDAGLTKLRRDKVGFIFQQFNLLPTLTALENILLPLSIAGRKPDKEWLDTVIDTVGLRDRLGHRPAQLSGGQQQRVACARALASRPEVIFADEPTGNLDSRAGAEVLGFLRRSVAEYQQTIVMVTHDPVAASYAGRVIFLADGQIVSELIEPTPETVLDTMKKLDGLAEAGL
>CP028158.1|AVT28648.1|758527_761074_-|ABC-transporter-permease
MLRATLKSLLARKVRLVLSGLAVVLGVMFVSGAFVLTDTLGRSFDTVFSDAYAGTDVGVSAKPKIDVSEMEGMPVAATFPASTLEQVRGVSGVASATGLAAADGARVIGSNGKVLTSVGPPQIGANWTGESGQVELREGRGPTADNEVAVNAGVAKAAKLAVGDRVGVLTLQPKRDFTVVGIYGYSGDRDSLGGAQEVAFTERVAQELMLGQPGVFSELSVKAADGVDPAKLRNDIAATLGDGYVVKTGEQLSEDASAGLKEGLAFFNNILLGFAGVALFVGIFLILNTFSIIVAQRTKELALLRAIGAGRRQVIGSVLVEAVAIGLVASVLGLGAGIGIGALLAYVFGQTAGGLQLAGLGVPPAAVISSFAVGLVVTVIAAVLPAMRAARIPPVAAMQDVATPDRPLTKISAAGAVVAALGGTLMALGLSGNGGNTLLTILGGVLLSFVGVALLTPLISRPVVGLLGRLFSWSVPGKLGRLNSGRNPRRTAITAAALMVGIALVTGVTVILDSAKSSLTALAEDTIQAELVISGAQTGPRPPSFDPAVLDRAAELPGVAMVAGLYGDRAVIGGKQGWITATSSVPALREIYRATPTAGSIDSLGPGQLLVDSETAKDRGLSVGDTLPVQLSRGDARNYTVSGIYAESELFGGFVVPASAAADFAVPQPTQAYLKLAPGASVDQVMPSVETLLADSPEVSVADRADFIEQQTGQLDGLLTMIQILLALAIVIAVLGIVNTLALSVLERTRELGLLRAIGLRRGQTMRMITVEAVVISVFGALLGVVVGTGLGAAVVRALREDGITDLVLPWTEMGVFLGLAAVVGVVAAVLPAIRAARLNVLGAIAHE
>CP028158.1|AVT28647.1|757740_758394_+|HAD-family-hydrolase
MLFDMDGTLVDSERLWDIGLQELAAHYGGTLSDAARLAMVGTDMAVSMEILHTDLGQQWRDPAVSAAWVDRRVGELFLTDLKWRPGALALVTAVRAASVPAALVTSTRRAVVEIALETLGRDTFDVVVCGDEVAATKPDPEPYLTAARLLDVPISRCVAIEDSPTGVASALAAGAAVLAVPHAVPIDPVDGVRLLETLTGVDLDLLSGLLSPLDLSR
>CP028158.1|AVT34121.1|756806_757544_+|hypothetical-protein
MRPLRRTGRFWPLLALIVTLVVAGACFVGGTGGGGPEAPDDPGTSGANGTGEADGTMTVDEFRRDIDGAVRVAEEYWTGRFKASGERFQPIRRITAYQREGEVDCAGQGLPRNNAVYCSAGDFIAYDVNWAVAAFRQVGDAFLYYLLGHEYAHGVQVRLGIRYEFTIQQELQADCMAGAYLGDSVRAGALTIEEGDLDELSRGLRAVADEPGQPWFAEGAHGTAEQRTDAFFGGYERSLDACDLR
>CP028158.1|AVT28655.1|772994_773210_+|ubiquitin-like-protein-Pup
MATRDTGGQSQSGKARRDEEVDEVATEANPEVAERHAEITEDVDDLLDEIDSVLEENAEEFVRGYVQKGGQ
>CP028158.1|AVT28656.1|773527_774367_+|proteasome-subunit-beta
MAAAFDPTGRLPDVFLNVGTSSFTQFLSTAAPDLLPGRRPLPPGSASALAPHATTIVALTTADGVVMAGDRRGTMGNLISSRDIRKVHPADEYSLIGFAGTAGIALEMVRLFQVELEHYEKIEGAMLSLDGKANRLAAMIRGNLGAAMQGLAVIPLFAGYDLAAPDPVNAGRIFSFDVAGGPYEETGYDGIGSGSLFAKAALKKRYRPGLSTPDAIRLAVDALYDAADDDSATGGPDLSRRIYPVVMTATAEGTNRLSDAEAAEVAEAVVAARMENPGG
>CP028158.1|AVT28657.1|774427_775285_+|proteasome-subunit-alpha
MAMQFYASPEQIMRDRSELARKGIARGRSAVTLSYSDGVLFVAENLSSALHKVSEIYDRVAFAAVGRYNEFENLRRAGVRMADAIGLSFDRRDVTGRALANAYAQTLGAIFTEQSKPFEVEICVAEVGSTPEADELYRITYDGSVNDEPGRMAMGGQAEAVTGALREEHQPDMSLDAAVRLAVRALGSVGGEGGAPRTIAASQLEVAILDRRRVGRTFRRITGAALVSLLEGAPAKADGGEAAAAEPKAPAPGPDKPAESAGSADLEGKPKRAGGKSSGSAEKSE
>CP028158.1|AVT34124.1|775305_776226_-|dTDP-4-dehydrorhamnose-reductase
MTGAGGMLGRDLVAVLTARQRGRVTAATRAEVELTDPAAVRAAVAGHDIVVNAAAWTDVDGAEQQEAAATAVNGTGVANLAAACAEAGARLVHVSTDYVFAGDADRPYPEDAPTAPINAYGRSKLVGELAVARLLPQTGYLVRTAWLYGAHGPNFVTTMLRLAAVRPYLDVVDDQLGQPTWSYALAERLADLGAAAHRSAAPAGVYHGTASGRTSWYGLAREVFARTGLDPERIRPTSSDRFPRPARRPGYSVLGHAGWSRAGLAPMADWRAMLADALRPDGTLGTARRPPAPSDATEDRIGSGSR
>CP028158.1|AVT28658.1|776369_777386_-|dTDP-glucose-4,6-dehydratase
MRILVTGGAGFIGSEYVRMLLTGTGPRLAPSAVTVLDKLTYSGNLANLDPVRDDPRLRVVVGDICDPAVVDEVMAGHDVVVHFAAESHVDRSIHRAAPFVTTNVLGTQTLLEAALRHRTGRFVHVSTDEVYGSIEQGSWTESTPLAPNSPYSAAKAGSDLLALAYHRTYGMDVVLTRCSNNYGPYQFPEKVVPLFVTNLLDGGTVPLYGDGGNVRDWLHVHDHCVGVALVQDKGRPGEVYHIGGGTELTNRELTGRLLAACGADWDRVRPVTDRMGHDRRYSLDITKISEELGYAPSVDLDRGLAETVTWYRENRAWWEPLKARLSGEEIGRPGPAPR
>CP028158.1|AVT28659.1|777483_778356_+|glucose-1-phosphate-thymidylyltransferase
MRGILLAGGTGSRLWPITQAVSKQLMPIFDKPMIYYPLSTLVMAGIREILIITTPGDQGQFRKLLGDGSQWGLRLEYVAQPSPDGIAQAFLLGEEFLAGDSVALILGDNIFYGAGLGRSLARNGDPDGGRIFAYPVANCEGYGIVEFDSEGRALSIEEKPEKPKSRYAVPGLYFYANDVVEIARGLTPSDRGELEITAVNQTYLAAGRLQVTALDRGTAWLDTGTFTSLVQAGEFVRVIEERQGLKVGCIEEVVWRSGLISDEQLRELAQPLSRSGYGEYLFGILEDPGR
>CP028158.1|AVT28660.1|778478_779837_+|Pup--protein-ligase
MERRIFGLETEYGVTCTYRGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGARLYLDVGSHPEYATPECDSVSDLVAHDRAGERILEGLLVDAEKRLHDEGIAGEIYLFKNNTDSAGNSYGCHENYLVSRHGEFGRLADVLIPFLVTRQLICGAGKVLQTPRGAVYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMNEVTTLLKVGSADIVLRMIEAGVVMRDLSLENPIRAIREVSHDITGRRKVRLASNKEISALEIQQEYLAKATEFVERRGGDQTAKRVVELWGRVLRAVETGDLDPVSREIDWVTKLQLIERYQRKNDLPLSHPRIAQMDLAYHDLRRGRGLYGLLERRKQVDRIATDPEIFEAKETPPQTTRARLRGEFIRHAQEKRRDFTVDWVHLKLNDQAQRTVLCKDPFRAYDERVERLIASM
>CP028158.1|AVT28661.1|779864_780068_+|hypothetical-protein
MTHPEGRDDDEHRRPETIRQNRVERRRAKIREEIERNRRGEYTVPTWVLTLILVLVVAGWLALVFLS
>CP028158.1|AVT28662.1|780084_781167_-|DUF3866-domain-containing-protein
MVRWRSGTVTAVRRSWHGAVELDVRQADGVRLRALAYPELVGTPEPGDRVLLNVGALLMGLGTGGYALVVALPDRLPADPPETVDSRDAGHLVKARYTPLQPILLGVDEEASPHRAALADADDLGGLPVVTADLHSALPAIVAGIRADAPGARIAYLMTDGGALPAWFSRTLHGLRGELAGTVTVGQAFGGDLEATNLHSGLLAARHVLRADVAIVAQGPGNLGTGTRWGFSGVAVGEAVNAVATLGGRPVGSLRISGADPRDRHRGLSHHSVTAYGRVALAAADLVLPAELPAELAALVEPAVAELARRHRIVRVPVEGLDEALRASPVPLSTMGRGLAEEHAYFLAAAAAGRYAAGLG
>CP028158.1|AVT28663.1|781185_782118_-|cation-transporter
MPERDDTSESVLTVVVAGLANLAIALAKVVAGVISGSAAMLSEGAHSIADTTTEVLLFTALRRGARPADVEHPFGYGKESYVWAFIAAVFTFVVGAGFSITHGVNTIRGGEHTGEFLVSYVVLAVSFLIESVSLARAVRQIRRASRARRISSARFLRSTADTTIKAVFLEDTAALIGISLAAGGLALSHSTGTEFWDGLASILIGLLLLVVATILARSNISLLVGRAVPRPMHDQIHRELSALPTVDRVDTLLTMHLGPDDILVAAKVDFRDEATGAEIEAGAEEAERRLVARFPHVRYVFLDPTRSGRP

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Crispr_ID: CP028158_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_3

890579-890689

Orphan

Consensus_repeat	Method
ATGCGGCGCGACGACGCCCGGTCAGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_3

>merge|CP028158|3|890579-890689|CRISPRCasFinder
ATGCGGCGCGACGACGCCCGGTCAGCGGAATGCGGCAGGCCGGCGGCGGTGAGCGGATGCGGCCTGCCGATAACCCTGAGCGGATGCGGCGCGACGACGTCCGGTCAGCGG

>CP028158|3|3|890579-890689|CRISPRCasFinder
ATGCGGCGCGACGACGCCCGGTCAGCGG	AATGCGGCAGGCCGGCGGCGGTGAGCGGATGCGGCCTGCCGATAACCCTGAGCGG
ATGCGGCGCGACGACGTCCGGTCAGCGG

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT28761.1\|900478_901489_+\|dipeptide/oligopeptide/nickel-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
CP028158.1\|AVT28749.1\|877405_878623_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274511
CP028158.1\|AVT34133.1\|882317_883538_-\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT28765.1\|905125_906103_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|153418
CP028158.1\|AVT28750.1\|880389_881556_+\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
CP028158.1\|AVT28757.1\|892313_895175_-\|glycine-dehydrogenase-(aminomethyl-transferring)	unknown	unknown	gnl\|CDD\|235432
CP028158.1\|AVT28758.1\|895648_897352_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173874
CP028158.1\|AVT28753.1\|885422_885926_-\|peptide-deformylase	unknown	unknown	gnl\|CDD\|234668
CP028158.1\|AVT28762.1\|901532_902168_-\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239473
CP028158.1\|AVT28763.1\|902505_903501_+\|aldo/keto-reductase	unknown	unknown	gnl\|CDD\|381377
CP028158.1\|AVT28751.1\|881552_882215_+\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107
CP028158.1\|AVT28754.1\|889206_890454_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226729
CP028158.1\|AVT28748.1\|876389_877409_+\|integrase	unknown	unknown	gnl\|CDD\|234698
CP028158.1\|AVT28760.1\|898344_899268_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
CP028158.1\|AVT28752.1\|883781_884204_-\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT34135.1\|886133_889145_+\|ATP-dependent-helicase	unknown	unknown	gnl\|CDD\|223627
CP028158.1\|AVT28759.1\|897361_898345_+\|peptide-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
CP028158.1\|AVT28764.1\|903676_904915_-\|FAD-binding-monooxygenase	unknown	unknown	gnl\|CDD\|169028
CP028158.1\|AVT28756.1\|892056_892257_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT34134.1\|884497_885277_-\|endonuclease	unknown	unknown	gnl\|CDD\|226098

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT28749.1\|877405_878623_-\|hypothetical-protein	gnl\|CDD\|274511	TIGR03300, assembly_YfgL, outer membrane assembly lipoprotein YfgL. Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking].	0.00366383
CP028158.1\|AVT28761.1\|900478_901489_+\|dipeptide/oligopeptide/nickel-ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.85941e-114
CP028158.1\|AVT28765.1\|905125_906103_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|153418	cd07377, WHTH_GntR, Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators. This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.	8.7795e-14
CP028158.1\|AVT28757.1\|892313_895175_-\|glycine-dehydrogenase-(aminomethyl-transferring)	gnl\|CDD\|235432	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase.	0
CP028158.1\|AVT28758.1\|895648_897352_+\|hypothetical-protein	gnl\|CDD\|173874	cd08509, PBP2_TmCBP_oligosaccharides_like, The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold. This family represents the substrate-binding domain of a cellulose-binding protein from the hyperthermophilic bacterium Thermotoga maritima (TmCBP) and its closest related proteins. TmCBP binds a variety of lengths of beta-1,4-linked glucose oligomers, ranging from two sugar rings (cellobiose) to five (cellopentose). TmCBP is structurally homologous to domains I and III of the ATP-binding cassette (ABC)-type oligopeptide-binding proteins and thus belongs to the type 2 periplasmic binding fold protein (PBP2) superfamily. The type 2 periplasmic binding proteins are soluble ligand-binding components of ABC or tripartite ATP-independent transporters and chemotaxis systems. Members of the PBP2 superfamily function in uptake of a variety of metabolites in bacteria such as amino acids, carbohydrate, ions, and polyamines. Ligands are then transported across the cytoplasmic membrane energized by ATP hydrolysis or electrochemical ion gradient. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.74061e-133
CP028158.1\|AVT28753.1\|885422_885926_-\|peptide-deformylase	gnl\|CDD\|234668	PRK00150, def, peptide deformylase; Reviewed.	1.6985e-68
CP028158.1\|AVT28762.1\|901532_902168_-\|carbonic-anhydrase	gnl\|CDD\|239473	cd03378, beta_CA_cladeC, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	7.79937e-63
CP028158.1\|AVT28763.1\|902505_903501_+\|aldo/keto-reductase	gnl\|CDD\|381377	cd19151, AKR_AKR14A2, Salmonella enterica aldo-keto reductase (AKR) and similar protein. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).	0
CP028158.1\|AVT28751.1\|881552_882215_+\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.2613e-69
CP028158.1\|AVT28754.1\|889206_890454_+\|hypothetical-protein	gnl\|CDD\|226729	COG4279, COG4279, Uncharacterized conserved protein [Function unknown].	5.04507e-40
CP028158.1\|AVT28748.1\|876389_877409_+\|integrase	gnl\|CDD\|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	4.94035e-50
CP028158.1\|AVT28760.1\|898344_899268_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	6.73114e-72
CP028158.1\|AVT34135.1\|886133_889145_+\|ATP-dependent-helicase	gnl\|CDD\|223627	COG0553, HepA, Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair].	1.01833e-121
CP028158.1\|AVT28759.1\|897361_898345_+\|peptide-ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	7.26688e-101
CP028158.1\|AVT28764.1\|903676_904915_-\|FAD-binding-monooxygenase	gnl\|CDD\|169028	PRK07588, PRK07588, FAD-binding domain.	9.4404e-105
CP028158.1\|AVT28750.1\|880389_881556_+\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	9.00668e-47
CP028158.1\|AVT34134.1\|884497_885277_-\|endonuclease	gnl\|CDD\|226098	COG3568, ElsH, Metal-dependent hydrolase [General function prediction only].	5.90496e-17

>CP028158.1|AVT28754.1|889206_890454_+|hypothetical-protein
MSGDDRVRGFPAFPPGRRARSSRSWWGDAWIRALEETSLDETLLRRGRRSATAGHVGSITVSPGRIAAEVHDGVRDVPYRTRVFVEPMTDAQWSRFLDQVAAKAGHIAALLDGEMPRDLASSADDVGVALLPGLGDLQPECDCPEWVAAACRHAAALCYQVAWLLDADPFLLLLIRGRGSREVLAELRRRGQRATAAAPVEQPAGRAPGVGVPAALAYARPDPPLPDPPPAPEPGVSGPVLPDAPGIAAEVLHGLVENAAVRAAALLDAASGDHGPPTVLPERVDAVRLAVGASGPVLARLRQAAGRTAREFGRAVRAWEYGGQTGLSVLDEAWTPPPVRLARARADLTAGWTGDDPPEPQVWRNRWTFPGHRAQLRYGRDGRWYPYRELTGGDWWPAGIPRDDPADALADLLGD
>CP028158.1|AVT34135.1|886133_889145_+|ATP-dependent-helicase
MRPNTTSVPGDASPPARSAEAGPDERWTAPCAVVFEPADPPRAGVLAFWRPDGGELPVDGPGRGGELTVVLPDGAGVRTRVVPARRLPVGDALPLLLADLASDRPVDPALAYWSAAALLALHLVARRRILPTVSPAGFDAWTVGALDAADAGRIRELAAAMPTRARANPFPAKPLPADKTTADGMTADDITADEMTAVGMTADEITADRMTAGRAAAGEAGAGPVLPDAAGLLRGFLDAVADTLPRSPAARHAAGTDAFAATAPQSLPRLRGWAEEVRAGLDSGVRVSIRLEPVDGDLTRPGLRAVAQVHSLVDPALVVDAAALWHGDVAGFGPRARLDTTLAIRRAAGVWPPLRHLLDAAVPDALLLTDEEVSELVADAAGRLGTVGVAVHWPRELTAGLTSRAVLGAAEAPPSDLATFFGGDGLLRVDWQLALGGRPLTAAELDLLAEAHRPVVRLRDQWVLVDPELAARARKPGLPPVGAIEALGAALTGTVEVDGRPVEVDTTGWLDGLRRRIADPEQAGDPERVGVPAGLTATLRDYQLRGLRWLAWMTELGLGGCLADDMGLGKTVTLIALHLHRQADPATAGPTLVVCPASLLGNWEREIARFAPGTPVRRFHGGRRSLDALDGGFLLTTYGTMRLDADRLAEVRWGLVVADEAQHVKNRASGTARALRRIPAAARVALTGTPVENNLTELWAILDWTTPGLLGPLPRFRARWAAPIESGRDPAAAGRLARLIAPFLLRRRKSDPGIAPELPPKTETDHSVGLTGEQAGLYEAVVRETLARIRDSSGMARRGLVLELLTSLKQVCNHPAHYLREARPRLAGRSGKLELLDELVDTILAEGGAVLVFTQYVAMARLIERHLGDRGVPTELLHGGTPVTRRDEQVRRFQAGEVPVFLLSLRAAGTGLNLTRADHVVHYDRWWNPAVEEQATDRAYRIGQTRPVQVHRLVTEGTVEDRIAALLAVKRDLADAVLTGGEAALTELSDAELASLVELRRPA
>CP028158.1|AVT28753.1|885422_885926_-|peptide-deformylase
MTMRPIRIIGDPVLRTPSEPVTSFDAELRDLVTDLMDTLLGAPGRAGVAAPQIGISAQVFVYDADGHRGHLVNPTLELSAETQDDDEGCLSVPGLYFPTPRAMHATAHGFDQYGEPLTITGSGFLARALQHETDHLHGRLYVDTLRGDARRRALREIRAGRFATPER
>CP028158.1|AVT34134.1|884497_885277_-|endonuclease
MRLATFNLLHGRSPHDGLVDENRLAAAVATLDADILALQEVDRDQSRSNHLDLTAIAARAMNAPEHRFAAAVVGTPGERFRPLTHDDDGHGEPLYGIGLVSRYPVRSWQVTRLASAPVRSPVLDPGPGGGIILLRDEPRVVLAAILDTPYGPITAAATHLSFVPGWNLRQLRQVIRALRTLPPPRILLGDLNLPAGLATLVSGWRSLGHRPTYPARQPRVQLDHILADPRDGHPLPAVTAVDAPIATISDHRPLVVDLA
>CP028158.1|AVT28752.1|883781_884204_-|hypothetical-protein
MSVRQLSAAATAALLGALWHAAPAAAHVTGQPVAASVTTMSPGRIGSIVAGLLGLVGIVVGALARARSTGRLGTGNARRGALTAIALGLVGALIGAVVVATSDGGLGTGNGLGGAIVALALGATGMLLGGLTLNRTRHTG
>CP028158.1|AVT34133.1|882317_883538_-|hypothetical-protein
MAVTVTIATVVLPTSPAAAAYADPLVATSKTNMGLTWHAESSAAIQALDNALPNVGVATVLDDANRTMTTCNSEELAALPIAPVATNKWCFDTADATDLNWSPQGITSSGDADDDGAWGAKRAILSGWSWGSGTRRNDARVAFIDYTNPAAPKYRWVYLVDPNSTGSDFSAAKTHIGGMIWFGDKLIVNAVGNGTVALRVFSMSHILQTTSTVSDIGKVSGGWAAYGYKYVMPQIGYYTYSSGACSMDSDTGTPCFSSLSLDRSTSPDSLVTAEYFSDQTKRGRLIRYPFGADYLLPTSATPSEAYASGVGNQQGVLSFNNRWYVVHSSFSLYGQIWGFTPGGGNGRSSTCTVDGEVKTTCWSLHPEAVTYWYSTGEVWSTTEWSRDNPTGPGGRVLYSVPLNSLP
>CP028158.1|AVT28751.1|881552_882215_+|DNA-binding-response-regulator
MIRLLLADDQTLVRAGFRSILEGEEGIEVVGEAADGAEAVRLTRRLRPDVVLMDIRMPGLDGLAATGEIAASSDARVIILTTFDLDDYVYGALRAGASGFLVKDTEPAELIHGVRVVARGDALIAPSITRRLISEFSARVRHPDPGPRLRALTEREREVLALVAAGLSNDEIAARLVLSPATAKTHVSRIMTKTQVRDRAQLVILAYESGLTVPGWLGRS
>CP028158.1|AVT28750.1|880389_881556_+|sensor-histidine-kinase
MPRWRVQGRAADVALVLVVALVGLGGLVVQSAGVDSAAEWVALLAVLVSSGALYVRRRYPVPVGVVALVAVGGYGALLHRPGPIMLVFVVALYTVVDEGRLWVAVGLGVASVVAFAAADSYGRTAGGGNGATLLHAGWLVAVIVGVTRNRRAYLVEARARVLAAEQGKEEEARRRATEERLRIARELHDVLGHHLSLINVQASAALHRPDPGRSAEALAAIKQASKEMLGELRTALGVLRQEDEAVTVPGLDRLGELVLTAGRSGLEVRTEVARPRALPPEVELAAYRIVQEALTNVTRHAGASAAVVRVRRDGDDVLVEVEDDGTGGPGVPGNGIVGMGERARALGGSLSAGPGPGGGFRVSARLPLRGGVLSAGSAGLSPESGAVS
>CP028158.1|AVT28749.1|877405_878623_-|hypothetical-protein
MHGADVISAVAGNRSTEVVALTATAGPPRWTATLPIEPTDLRLTAVQDLIVVDGENSVTNGGQDVRAVLSGKDGRLLWQRTWPDRVDVAYYGTDAVIETLGGSDDLAISRVNLRTGRQVWSKSGEPDALSSDEHRAEPVRQWPAPGTPAPGLLPAVAGSYHDAPGATNTIVELDSANDRGYVLDATTGKVRGSGKLPLEPDLWTGYDNAVIGKTTGNDHVLAAYDVPGLRLRWKMPLAAGDIVERIKPCAATRVCAAITNGAEHRVVALDTRSGKPGWTAQAEHSDQNWYAHDDTLVTGRGTFDSLSHPRLISGTSGQAQRELPELASLEAAAGGRLVLGSVAGSPPRWHLQVADTTLGEGTDRLAVGGKAPEQVVIADNLVGVVTTDRRTLVLDVAGLRTATPR
>CP028158.1|AVT28748.1|876389_877409_+|integrase
MQDKEDFLLLPLVEQFLTSRATRKPSPHTLAAYRRDLLAVARLVADDQPGTPLPLAALPIRALTTRSIRAAFARFAAPRAAASIYRAWSTWNGFFDFLVAEQVVAGNPMPAVDKPRVPPAPPKPLRGERTPEQLLAGVVESDRRQRDPWPERDLAVLALALCAGLRLAELLALRTGSLVGRDGERRVEVIGKGSRSRLIPVEPELDRVIVDYLESRRRRFGSRTVGPDSALLVDREGKPLRRGGLQYLVESCYRRAGITDRVPPGARLHALRHTFATRLAEDGASAPEIMRLLGHASLATSQNYIEVTGEQERAAVRANRTNRSLGRLLSQRSVADGAG
>CP028158.1|AVT28756.1|892056_892257_+|hypothetical-protein
MCQHEPTCPSAEATDREAARVLACFREQGWSLLCNGVILFEDTGELLPDGSTIAPHRGPARHALVG
>CP028158.1|AVT28757.1|892313_895175_-|glycine-dehydrogenase-(aminomethyl-transferring)
MTTAQQPTRDGGAFADRHIGPDADAMRRMLETVGYHSVDDLMDAAIPEVIRWTGDLDLPPAATEEEVAAELRALAARNTVAVSMIGLGYSGTHTPAVIRRNVLENPAWYTAYTPYQPEISQGRLEALLNFQTMVTDLTGLATANASMLDEGTAAAEAMTLARRAGKNKSNVYVVDADTLPQTLAVLATRAEPLGIEVRVLDLSAEPLPAEFFGLHLQYPGASGAVRDHSGLVEAAHAAGALVTVAADLLALTLLRPPGEIGADIAAGTTQRFGVPMGFGGPHAGYLAVRGGLERMLPGRLVGVSRDAAGDRAYRLALQTREQHIRREKATSNICTAQVLLAVMASMYAVYHGPAGLRAIAERTHHRAATLAAGLRTLDGVEIVHETFFDTVLARFPGRAAEVVAEAARRGVNLRPVDADHVGIACDETTTEAHLTTVWDAFGAVAGQPVTPATGQPPAALPADLARDSDYLTHPVFRSHHSETAMLRYLRRLADLDYALDRGMIPLGSCTMKLNATTEMEPVSWPEFANVHPFAPEEQTAGYRDLVGTLEGWLAEVTGYDAVSVQPNAGSQGELAGLLAIRAYHRDRGEGHRDVCLIPSSAHGTNAASAVMAGMRVVVVGCDPDGDIDLADLDRKIEAHRDTLAAIMVTYPSTHGVYEAGIAALCARVHDAGGQVYVDGANLNALLGYAKPGRFGADVSHLNLHKTFCIPHGGGGPGVGPVAVRAHLAPYLPGDPRDTEGRPAVSAARYGSAGILPIPWAYLRMMGPDGLRRATGVAVLAANYVAARLRGHYPVLYAGNKGLVAHECILDLRPLTKATGVSVDDVAKRLIDYGFHAPTMSFPVAGTLMVEPTESEDLAELDRFCEAMIAIRAEIDKVGAGEWPKGDNPLANAPHTAAMVTGDEWPHPYPRSVAGYPGGVDRQAKYWPSVRRIDGAYGDRNLVCACPPPEAFEN
>CP028158.1|AVT28758.1|895648_897352_+|hypothetical-protein
MAKSPNREATMRRTLARRLLATLATATLAVGVTAGCGDDGDSSADAEGKIINVLSGTNAGFVPNFNPFSQNSVAGTMSVLYESLLYFNAARADDVQPQLATGYEFADDGRRLNLTIREGVKWTDGKPFSAEDVAFTFNLIRDNPKLNQNGLPIVEAVATDPTHVSVTFSQGVYTRLNLIAGRTWIVPKHIWSTIADPSAFTNEKPVGTGAFMLASFSQQNYVFERNPNYWETGKPKIKGMRFQQFASADSAIAALAAGQLDWAGSFIADIEKQYVSKDPKHNKYINESQLYLTNLIPNLDRAPFDSAAVRKAISLALDRDQIIRLAFSGYGKEASPAQLPRPLWDDYIKPEHKDRKLEFDPARAEQTLQADGWAKGADGIYAKAGRRLSFTVKVVQGYNDYISALQIMTQSLKSVGIEMKTQEVSFTAFSTDQQTGDFEMIITNLYSEGTAYSWYSRAFSSKRTAPLGQQAGSNYGRFRNAAVDAALLAMENTPPDQRDAIREQLFKIQDVIVEELPYIPLQQSASLIEYRTENLGNFPTEENHYALTTPYNGPDMGIVAKNLTPAG
>CP028158.1|AVT28759.1|897361_898345_+|peptide-ABC-transporter-permease
MRYLRRKALFYLVAVWAAVTLNFLIPRLIKGNPVDAVLAKTQNMTPMSPDARRALELQFGVTDDPLWQQYLGYLGNLLRGEFGLSVSYYPTPVSKVLSQSLPWTVVMVGVATVLSVLLGITLGMLAGWRRGTWLDALVPTTTFLAAIPYFWLALVLLYLLGGILGWFPLNSGYSYETTIGFNWPFLRSAIYHAVLPAASIVLASVAGWLLGMRNMMVSTMAEDYVLTAEAKGLRPRRIMIQYAARNAVLPSVAGFAITLGFVVSGSIATEIVFSYPGVGMTLVAAVANADYPLLQGIFLVISLAVLGANFVVDLLYAVIDPRTRQAG
>CP028158.1|AVT28760.1|898344_899268_+|ABC-transporter-permease
MATIETQRDVTGEVVPGVVVPTRRPRWRGLLRSRKLAAGLAIVGFFALVAVLGPLLVDDPNQVSDDRLLAPSAEHLLGTTTTGQDVFRQLVAATRGSMLVGLVVGLLATVVSVLVGVLGGYAGGHTDESLSLVSNVFLVLPGLPLVVLITDYVQTRGALAIALIVSFTAWAGSARVLRAQTLSLRSRDYVDAARVSGEPGWRIVTFEILPNLLPLIAAQFVFAVIGGILTEAALAFLGLGGAGSWGTMLYFAQNSQALSQGAWWWFVPPGLCIALVGAGLALINFSLDELINPRLRVPRRPRRTGPA
>CP028158.1|AVT28761.1|900478_901489_+|dipeptide/oligopeptide/nickel-ABC-transporter-ATP-binding-protein
MTTLTVSHLSKHFPLRDGRRRRTLRAVDDVSFELRSGQTVALVGESGSGKSTIARMLVRLTPPTAGEIRLDGTPVAAGHRAVRRYRRDVQMVFQDPFGSLNPAHTVEYHLRRPLRLHGVARSADDVRAAVHDLLTRVNLTPADQVARRLPHELSGGQRQRVAIARALAPRPRILLADEPVSMLDVSIRLEILNLIDRLKREEELAVLYVTHDLATARYFASSIMVLYRGQVVESGPSDEVILRPAHPYTQLLASAAPDPGRPRTAAPGGMRALRGGQQTATDSGGCLFRDRCPAAMEVCRTEVPEFPVGAAHLARCWLHRPDNGRPRPADGSAGQP
>CP028158.1|AVT28762.1|901532_902168_-|carbonic-anhydrase
MAYLDHRPATPTEALDELLAGNERFVAGTRIHPHQDAEHRAVVAAAQRPFAVVFGCSDSRLAAEIIFDRGLGDLFVVRTAGHIVGPEVTASIEYGVVVLGAPLVVVLGHDTCGAIQATRAALDGARLPGRDLGAIVERVTPSIEAAQARQVSDDAGIAAIHTRHTIETITGPGTELADAVAAGRCDVVGMFYKLADGRVSLTVPGAAPTAG
>CP028158.1|AVT28763.1|902505_903501_+|aldo/keto-reductase
MTYLAADDRYDSMTYRRAGRSGLRLPAISLGLWHNFGDERPWQQQREICRRAFDLGVTHFDLANNYGPPAGSAEENFGRTLAADLAPYRDELVISTKAGYYMWPGPYGEWGSRKYLVSSLDQSLRRMGLDYVDIFYHHRPDPDTPLEETMAALDAVVRAGKALYVGLSNYTSEQTRQAAAILQRLGTPLLISQPSYSMLNRWIEADRLLDTLEEAGAGCIAYSPLAQGVLTDRYLDGIPADSRIRTSVFLNESDLDETTMATVRALHAIAQGRDQSLAQLALAWALRDSRMTSLIIGASSVAQLETNVAALENLTLTDSELAEIGGHLTVD
>CP028158.1|AVT28764.1|903676_904915_-|FAD-binding-monooxygenase
MTSRTVLISGASIAGPALAYWLRRHGFEPTVVEVAPGPRPGGQAVDLRGAGREVVERMGLMPRVREARVDERGVANVDANGRWMARMPADLFGGEGIVAEIEIMRGDLTRILHDATTGEVEYLFADRITELDQGASGVRVRFASGTTRTFDLVVGADGVHSGVRRLAFGPEREYVQPLGGYTAYFTVPDPGDLNGWFLMYNSPGGRVAGIRPERGGTAKAMLSFTSPPLEYDRRDVDRQRRLLTDAFAGVGWRVPALLDALPDAPDFFFDSICQVHVPNWSRGRVTLLGDAGYCGSPLSGMGTSMALVGAYVLAGELAGAGGDHEPAFARYQQVMRDYVRQCQELPPGGIGGFAPRTRSMIWLRNQSMRMMGHWPMRHILARQFQKADAITLADYATASAPRPSGAPHRRLG
>CP028158.1|AVT28765.1|905125_906103_+|GntR-family-transcriptional-regulator
MRRDRGDRVSRPEAPYLRIVDEIRRRIAAAELRPGDQVPSARQISQEWGVAIATATKVHAALRQLGLTEARPGIGTVVASAPKPARVPADERARRPRGPARPRGEGELSRERIVGVAIAVADADGLAELSMRRVATELDVATMSLYRYVAGKDELLLHMIDTVLGEEEVPPPSREGWRTDLARIARLEWRTLRRHPWLAPAMSITRPQLTPNTLALTDGVLHALDGLGLDSETQLYVHLTLFSFGRGLAAAIEPETEAQRDTGLTNDEWMDSQQARLAELAAAGSPLLRMALRNDFDFDLDRLFEFGLARLLDGLARHLSDDGGP

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Crispr_ID: CP028158_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_4

1981702-1981786

Orphan

I-E

Consensus_repeat	Method
GGATCATCCCCGCATGCGCGGGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_4

>merge|CP028158|4|1981702-1981786|CRISPRCasFinder
GGATCATCCCCGCATGCGCGGGGAACAGGCTTGTTGCTCGGCGAGCCGCAGCTCTCGCGGGGGATCATCCCCGCGTGCGCGGGGA

>CP028158|4|4|1981702-1981786|CRISPRCasFinder
GGATCATCCCCGCATGCGCGGGGA	ACAGGCTTGTTGCTCGGCGAGCCGCAGCTCTCGCGGG
GGATCATCCCCGCGTGCGCGGGGA

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT34284.1\|1979593_1980142_-\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
CP028158.1\|AVT34283.1\|1977736_1978114_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
CP028158.1\|AVT29516.1\|1985766_1987014_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380561
CP028158.1\|AVT29506.1\|1972230_1974426_-\|magnesium-chelatase	unknown	unknown	gnl\|CDD\|274135
CP028158.1\|AVT29521.1\|1990227_1991043_-\|citryl-CoA-lyase	unknown	unknown	gnl\|CDD\|235748
CP028158.1\|AVT29513.1\|1982012_1982729_-\|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223487
CP028158.1\|AVT29510.1\|1978116_1978812_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT29518.1\|1988123_1988948_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|131484
CP028158.1\|AVT29520.1\|1989334_1990216_-\|extradiol-ring-cleavage-dioxygenase	unknown	unknown	gnl\|CDD\|153372
CP028158.1\|AVT29519.1\|1988975_1989338_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|153390
CP028158.1\|AVT29514.1\|1982721_1984983_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|213186
CP028158.1\|AVT29522.1\|1991024_1992191_-\|carnitine-dehydratase	unknown	unknown	gnl\|CDD\|367110
CP028158.1\|AVT29515.1\|1984772_1985651_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
CP028158.1\|AVT34285.1\|1981360_1981672_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT29508.1\|1976075_1976828_+\|precorrin-4-C(11)-methyltransferase	unknown	unknown	gnl\|CDD\|225430
CP028158.1\|AVT29512.1\|1980224_1980989_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377627
CP028158.1\|AVT29511.1\|1978840_1979482_+\|nitroreductase	unknown	unknown	gnl\|CDD\|376405
CP028158.1\|AVT29507.1\|1974771_1976085_+\|cobalamin-biosynthesis-bifunctional-protein-CbiET	unknown	unknown	gnl\|CDD\|225151
CP028158.1\|AVT29517.1\|1987150_1987651_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
CP028158.1\|AVT29509.1\|1976841_1977603_+\|precorrin-6A-synthase-(deacetylating)	unknown	unknown	gnl\|CDD\|236218

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT34284.1\|1979593_1980142_-\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	6.02878e-08
CP028158.1\|AVT34283.1\|1977736_1978114_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	4.94884e-29
CP028158.1\|AVT29516.1\|1985766_1987014_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380561	cd06338, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT); however, their ligand specificity has not been determined experimentally.	2.8823e-87
CP028158.1\|AVT29512.1\|1980224_1980989_+\|hypothetical-protein	gnl\|CDD\|377627	pfam06197, DUF998, Protein of unknown function (DUF998). Family of conserved archaeal proteins.	4.35013e-09
CP028158.1\|AVT29521.1\|1990227_1991043_-\|citryl-CoA-lyase	gnl\|CDD\|235748	PRK06224, PRK06224, citryl-CoA lyase.	4.21224e-87
CP028158.1\|AVT29513.1\|1982012_1982729_-\|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|223487	COG0410, LivF, ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism].	5.57979e-112
CP028158.1\|AVT29517.1\|1987150_1987651_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	5.40151e-10
CP028158.1\|AVT29518.1\|1988123_1988948_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|131484	TIGR02431, p-hydroxybenzoate_hydroxylase_transcriptional, beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family. Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions].	7.22294e-85
CP028158.1\|AVT29520.1\|1989334_1990216_-\|extradiol-ring-cleavage-dioxygenase	gnl\|CDD\|153372	cd07359, PCA_45_Doxase_B_like, Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes. This subfamily of class III extradiol dioxygenases consists of a number of proteins with known enzymatic activities: Protocatechuate (PCA) 4,5-dioxygenase (LigAB), 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), 3-O-Methylgallate Dioxygenase, 2-aminophenol 1,6-dioxygenase, as well as proteins without any known enzymatic activity. These proteins play essential roles in the degradation of aromatic compounds by catalyzing the incorporation of both atoms of molecular oxygen into their preferred substrates. As members of the Class III extradiol dioxygenase family, the enzymes use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon. LigAB-like class III enzymes are usually composed of two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents the catalytic subunit, B.	5.6397e-71
CP028158.1\|AVT29519.1\|1988975_1989338_-\|hypothetical-protein	gnl\|CDD\|153390	cd07321, Extradiol_Dioxygenase_3A_like, Subunit A of Class III extradiol dioxygenases. Extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into substrates using a variety of reaction mechanisms, resulting in the cleavage of aromatic rings. There are two major groups of dioxygenases according to the cleavage site of the aromatic ring. Intradiol enzymes cleave the aromatic ring between two hydroxyl groups, whereas extradiol enzymes cleave the aromatic ring between a hydroxylated carbon and an adjacent non-hydroxylated carbon. Extradiol dioxygenases can be divided into three classes. Class I and II enzymes are evolutionary related and show sequence similarity, with the two domain class II enzymes evolving from the class I enzyme through gene duplication. Class III enzymes are different in sequence and structure and usually have two subunits, designated A and B, which form a tetramer composed of two copies of each subunit. This model represents subunit A of class III extradiol dioxygenase enzymes. The A subunit is the smaller, non-catalytic subunit. Enzymes that belong to this family include Protocatechuate 4,5-dioxygenase (LigAB) A subunit, 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase (CarB) A subunit, Gallate Dioxygenase and proteins of unknown function.	3.06073e-06
CP028158.1\|AVT29522.1\|1991024_1992191_-\|carnitine-dehydratase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	2.84106e-144
CP028158.1\|AVT29515.1\|1984772_1985651_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	1.72886e-49
CP028158.1\|AVT29514.1\|1982721_1984983_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	3.91753e-88
CP028158.1\|AVT29508.1\|1976075_1976828_+\|precorrin-4-C(11)-methyltransferase	gnl\|CDD\|225430	COG2875, CobM, Precorrin-4 methylase [Coenzyme metabolism].	2.10493e-120
CP028158.1\|AVT29506.1\|1972230_1974426_-\|magnesium-chelatase	gnl\|CDD\|274135	TIGR02442, Uncharacterized_protein_Rv2850c/MT2916, cobaltochelatase subunit. Cobaltochelatase is responsible for the insertion of cobalt into the corrin ring of coenzyme B12 during its biosynthesis. Two versions have been well described. CbiK/CbiX is a monomeric, anaerobic version which acts early in the biosynthesis (pfam06180). CobNST is a trimeric, ATP-dependent, aerobic version which acts late in the biosynthesis (TIGR02257/TIGR01650/TIGR01651). A number of genomes (actinobacteria, cyanobacteria, betaproteobacteria and pseudomonads) which apparently biosynthesize B12, encode a cobN gene but are demonstrably lacking cobS and cobT. These genomes do, however contain a homolog (modelled here) of the magnesium chelatase subunits BchI/BchD family. Aside from the cyanobacteria (which have a separate magnesium chelatase trimer), these species do not make chlorins, so do not have any use for a magnesium chelatase. Furthermore, in nearly all cases the members of this family are proximal to either CobN itself or other genes involved in cobalt transport or B12 biosynthesis.	0
CP028158.1\|AVT29511.1\|1978840_1979482_+\|nitroreductase	gnl\|CDD\|376405	pfam00881, Nitroreductase, Nitroreductase family. The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	4.25223e-26
CP028158.1\|AVT29507.1\|1974771_1976085_+\|cobalamin-biosynthesis-bifunctional-protein-CbiET	gnl\|CDD\|225151	COG2242, CobL, Precorrin-6B methylase 2 [Coenzyme metabolism].	1.94114e-60
CP028158.1\|AVT29509.1\|1976841_1977603_+\|precorrin-6A-synthase-(deacetylating)	gnl\|CDD\|236218	PRK08284, PRK08284, precorrin 6A synthase; Provisional.	5.58e-146

>CP028158.1|AVT34285.1|1981360_1981672_+|hypothetical-protein
MELDLDDFTTAVAARGAQWQAAGVQWQLHYGPTCSKSSAWVECTTARHLAQLIVWTSGEADLEVGDISTGAITITRYEMSNAAELTACFDTLTQWLTDPTPPA
>CP028158.1|AVT29512.1|1980224_1980989_+|hypothetical-protein
MYSQFMTSSPRVVPATRSDTRPSVQPGHPIARRLALGAVVGPALFTLAWLVLGVVSDGYTLFDHRFTDYSPVSQPISGLGMGATASYMNSAFVVTGLILLVGVVAVFRAVPTGRPALRRWSVVLLGCSGIGQAVCGIFNLEAVLPHTFGFVLAIGTPVAGFLVAGYYFRGVPGWRRFGSWLRLGSPLTLILLVAFFATFQPTADGAEQGIAGLVQRIGILELHAWFVAMGWLAYRRTPAGALERIGEVTGRRPG
>CP028158.1|AVT34284.1|1979593_1980142_-|PadR-family-transcriptional-regulator
MLTEEPMHAYRMQQLIKTRRKDDVVNVSQRNSVYQTIQRLVRDGLVAVVGTERAENRPERTTYRITDAGRAILADWLRAMLASPTAEYPEFPAALSFLPNLSPADAVAALTLRVTRLEERLAALDREIAEVATFLPRLFGIETEYRRQVVDAELRYVRDLVADLRAERITWPFVDGAPGRFG
>CP028158.1|AVT29511.1|1978840_1979482_+|nitroreductase
MEFAEVIRRRRMVRHYADRPLSPDVVDRILASALRAPSAGFSQGWAFLALTDPADRARFWPFVPTRVAQTPTMQDAPLVVVPLAHKAAYLARYAEADKGWTDRSEARWPAPYWYVDTGMATLMMLLTAVDEGLGACFFGIMPMAGDDFDPVVEVPAHTAAFKAEFGIPDEYSPIGGICVGYRAEDLPPQNPTIAGRRRDRDEVIHRGQWGRRS
>CP028158.1|AVT29510.1|1978116_1978812_+|hypothetical-protein
MDTIDSVMAEAERAWRAYGVGRADRAALAADLRLDLEAAAADGGDPAQLLGGDVTGFARRLADEAGVQRVRRHYGPLLGTALTGAVLGAVLGYAALALLYPMFVRAVDIPRSIEIPIQLAVVVYYGVPAAVVVTGAVVAVRLWLPEVPRIRRTSRLMGLLLPVAGILVTPLTMAFAWSTDYSTAPEVVVTEIAIVLAALGGATILARRLSLRDSREPSDTTGPYSAQVNSA
>CP028158.1|AVT34283.1|1977736_1978114_+|PadR-family-transcriptional-regulator
MIAAEHQPTDDNDRHTQLLRGVLDMCLLALLARQPAHGYELVRRMETADFGVISYGTIYPLLTRMRRLGLVADEQQASPNGPPRKVYALTDLGRAHLDAWQKQWNHFADTVGALLGPPDHDPSRS
>CP028158.1|AVT29509.1|1976841_1977603_+|precorrin-6A-synthase-(deacetylating)
MRKILVIGIGAGDPAQLTLEAVEAIAGVDVFFVLDKGAVKQDLLGLRQEILRRHPTKPGHRVVEVRDPDRDRSAPDYVDAVDEWRRRRAELLRSLVRDEVPVDGCGAFLVWGDPALYDSTLGVIEEMLTDGSVEFDYAVIPGVSSVSTLAARHRIGLNRVGRPFQVTTGRLLAQGWPAGVDDLVVMLDAHCTFLRVEEPDVQIYWGAYLGTADEILVAGPLAEVGPEIVEVRRAARERKGWIMDTYLLRRRAG
>CP028158.1|AVT29508.1|1976075_1976828_+|precorrin-4-C(11)-methyltransferase
MPVTFIGAGPGAADLITVRGQRALARAQVCLYAGSLVPAELLESCPPDAELVDTADLTLDEIVARMVDAHRAGHEVARLCSGDPSIYSAVAEQLRRLDEAGVPYEIVPGVPAFAAAAATLGRELTVPTVGQTVILTRARARSTVMPETEDLAVLGASRATLVLHLAVGRTRHLVEQLVPHYGADCPVAVVARASRPDELVLRGTLADIADQVEQAAVRRTAVIVVGRVLAAEGFPDSYLYSAGRDRSAKR
>CP028158.1|AVT29507.1|1974771_1976085_+|cobalamin-biosynthesis-bifunctional-protein-CbiET
MTATSARAGLTVVGIGADGWAGLGDAGRRALQDAEVVLGGRRQLDLLPAELPAERVSWPSPLLPALPGLLDGYAGRRLAVLASGDPMWFGIGVRIVELVGPERVQVLPHPSSISLACARLGWPVERVAVVSAVGRDLARVRRVLAPGRRILVLSADASTPSALAALLTDAGYGASRLVVLSSLGTGRKPQLDGAGREPQLDGGGWEPQLDGGGRERRLDGTAEEWSHPPGDPLNVVAVHATAGPDAVLRSTVPGLPDEAYAHDGALTKREARALALARLAPAPDELLWDVGAGSGSIGIEWLRAEPNARAVAVEARADRAERIVGNASALGVPELAVVVGRAPAVLAGLPTPAAVFVGGGLAADGVLDACWAALAPGGRLVAHAVTIEGERELTIRADRLGGDLTRLGVERAAPLGGFTAWKPARALVQWAVVKPCR
>CP028158.1|AVT29506.1|1972230_1974426_-|magnesium-chelatase
MRSYPFSAVVGMDDMALALTLSAVSPAIGGVLIRGEKGTAKSTIVRALTALLPPVTVVTGCRFSCDPAAPDPDCPDGPHDPAAPSATRPARLVELPVGATEDRVLGALHLERALRDGVTAYEPGLLASAHRGLLYVDEVNLLHDHLVDVLLDAAAMGRATVEREGVSVAHAARFVLVGTMNPEEGELRPQLLDRFGLTVEVAASRDPAVRAEVTRRRLGYEADPDGFAGRYAAADAERAARIARARRLLPEVQLDDDTLYRIATVCASFEVDGMRADLVTARTAMVHAAWCGRTTVTGVDIRAAARLALPHRRRRDPFDPPGIEQERLDQALADAGLDQPAEPPPDGGPPPQGPGPDEPDPGGPGGAPPPDDGLAPGSPPGTGPVPQVDAGPDGTTDGMGAERPDRVQVPAAPHGSAAPDGSADPDRPAGEGSGGSRTLAAGRPYRARLLVVPGVGAGVAGRRSPAVTTVGQTIRTTPAGAAAGNRPHLVATLWAAAPHQRMRGRRGPGLELRPQDLRMPVRQGREGNLILFCVDASGSMAARQRMREVKTAVLSLLLDAYQRRDKVGLVTFRGNAAELALPPTSSVDVAATRLAGLPTGGRTPLAEGLLRAGAVLRVERIRDPRRRPLLVLLTDGRATAGPDAVTRSRYAARLLAGSGVRSVVVDCEAGRIRLGLAVELADALGAEHLPLERVAAATLTGAVRDRTGTRTRNDHARDASGGVGSRWGRAA
>CP028158.1|AVT29513.1|1982012_1982729_-|branched-chain-amino-acid-ABC-transporter-ATP-binding-protein
MSEPLLRIRDLEVRYGDAQALWDVTLEVREGETVCVVGPNGAGKSTLVNAVAGIHPAHRGQISVGGTDITRLRGHRVCTHGVAVVPEGRRIFPRMTVLDNLMLGAYRREARREHRGTLAEVYEIFPRLAERAGQGAGSLSGGEQQMLAIGRALMARPRLLLLDEPSLGLAPVRVDEVYDAILRINGGGVSVLVVEQDVQRALDVASRAYLLGEGRVVLTGSADELRDSAEVRRSVLGL
>CP028158.1|AVT29514.1|1982721_1984983_-|branched-chain-amino-acid-ABC-transporter-permease
MVRHRFRGGDPRRDRRGGRYLRLRHPGRGALRRRLDGLVPGGRAVRALLGDHPGPAAAPAGTLRRRRRPVIRRGGVGLLVAFLVLAVLGASADRLGIGSFYLVLLGSICFWIAQATSWNLLSGYSGYFSFGQAAYVGIGAYTTAVLSGRHGVDFFLTLPIAAVLSGLLALGVGAVAFRLGSLRGEIFALLTLAVPFILAAFARINRSIDGGQGANVPVPTLPGPVSSFQQFQFLLALLVATLAVAVAYVVQHTRSGSALAAIRDAEDVAEVTGVATFRYKMLAMLLSGVLGGVAGSVYALQIGFVTVESVFGLTIPLFVIVMGVLGGRSHWLGPVIGAVLIVTLQDRLSSYGLDAYNMIILGGILALLVALAPDGLYARLRARPLVALGTLVGVSGALAVLQVWGELLDWLVVGMLAASLVAIVLGSPRISARLGLRPPGRRAEPAPPTAPADAKVADPGSVDPAPTDVASPEPVPADVAATGPAATHLPTVMDTRRIPVQVAGARGGESGAVLVECRGVARYFGGVHALEDVTLEIREGELVGLVGPNGSGKTTLVNLLSGTIRPTRGTIRIGGRDTTRLAPHRIAHVGMARTYQIPRPFDSMTVRDNVAMAIMFGRTPMSLHRARPIAERHLETVALGHLADAYPNGLNLHQRQLLEMARAVAANPRVLLLDEALAGLNPAEVDNAVQVVRRIHDSGITIVIVEHLLRVLNQLATRLVVLDRGSCLADGDPQTVLNDPAVVRAYLGRQAHV
>CP028158.1|AVT29515.1|1984772_1985651_-|branched-chain-amino-acid-ABC-transporter-permease
MPRMNVIQAALTGALIGGLYALMATGLSVTWGVLRVINLAHFGLILLGAYLTFQIATSWRLDPILTLVVTVPLMFVAGAAIQWLFDRLRLSEFNSLLVSFGLLSITIQLVSNVWSADFQRMPATVNPYATGSVALGRLVFPVTTLLAFGLAVAVVVGAHLVLRRTFVGRAMRAIAQDRAVAGAFGVDHRRLSVLLGGVVGATAALAGMVFALANALTPETAYEWFGTVFAVVILGGIGEVVGTFASGILVGVLSGVVSTVWSPAAAPFVLFSAIILALLLRPQGLFAAGGVR
>CP028158.1|AVT29516.1|1985766_1987014_-|ABC-transporter-substrate-binding-protein
MRRRSLAAVATVLALGAAATGCGNGSGSGSTDDPIVVGSTLSLTGAFAATGQIHKIAGEAYVARLNAAGGLLGRQVEWKVVDDQSDQSKVSQLYERLISQDRVDLVIGPYATPNILSAMAVAQRHGYVMPQHTAVLAPQLTYECQFPAWSIGPTPNRFIPTQLFDALAAQPGPPKTVAVLTSQSGSAAFVSDGYGDDKSGALSIARERGLDVVVDVHYPPTTTDWAPIATQVRDADPDLVINNGLGVDAVNILQAMAQLNYRPKRLFSLFPAPGPLLDLGEVSEGVLSVSMFEPNKPTLDRLGSPATEIVDDFTARAKAAGLPYPVFETQAAASWNAWEILTAAVRDTDGTDHRKMCDSLHGKGADTTFSGHLSFDPKVQNFWPTTQAIKQIQKGDWVTVWPADRAAAPFAPARS
>CP028158.1|AVT29517.1|1987150_1987651_-|DoxX-family-protein
MNLGLLLLRLLLAALLFGHASQKLFGWFRGQGPAGTGATFHTWGFRPGRQMALLAGAAELVGAALVALGLATPLGAAIVLGTMVVAASVNLPNGLWAHLGGCEVAAVYGALAVVLAYTGPGAWSLDHLVGLDGFAGYGWGSLALAVGLLGSVPPLLRRRRALAAGD
>CP028158.1|AVT29518.1|1988123_1988948_+|IclR-family-transcriptional-regulator
MAQRGEGPDFIEALARGLKVITVFHADHPRLTLSEVATAAGLARPTARRFLLTLEELGYVRAEAGSYELTPRVLELGMAYVGALSLWDIARPHMQDLVAATGESSSMAQLDGSDIVYMARVAVPKIIALRVQIGTRFPASVTSQGKVLLAALDPETLDTALAQPSRSGVQPKVRHSRTALDAMLREVRARGWALADDELAPGIRSVAVPIRDGQGAVRAAMNVTVNSAETSVKVLVEQHLPQLIRAASAISADWARWQSRPQVEVADAATAARH
>CP028158.1|AVT29519.1|1988975_1989338_-|hypothetical-protein
MSRYLLNKFLYTVDRDAELVERYREDPRGTVAWWEAERANAVLNCHTGEASTWLRFTDTEREALASHDYVKLFELGAHPFLTLTLFIAMFERDHPEPLAFQKQYAARLAHFALPYPDIAT
>CP028158.1|AVT29520.1|1989334_1990216_-|extradiol-ring-cleavage-dioxygenase
MATIAAVIASTHHPFYYRASTAQGEDRPPFADEWVRKILAFRETLTRANPDVLVMVGSDHFHQLWLDNMPQFLIGKAPFYDANWYNEEREFGLPRMLLRGQEELSAHLLRQGLDAGFDLAFSNELRIDHSITCPIITLRPEADLPIVPIYTNIFAPPLPQPKRFVQLGQTVRELVESWPSDLRVAIVGTGHLSLELGGPRQFGPHGPDPEFDRKAVEWIATGDLERCLAEVTLESLHSPGNATHGFMDFMLMMGVAGAGAKADHVDTLDLFHTMEAYFTWYPNGVPGGTGVAS
>CP028158.1|AVT29521.1|1990227_1991043_-|citryl-CoA-lyase
MADEELSFPTSIGTSDADSIRLLGHDLATELIGQVGFGELAFWLVAGRRPTPAQVRVFEAVLVSLADHGFTPTAIAARVTYQSAPEALQGALAAGLLGGGSRFLGVTEDCGRFLADTLAGLTELTDLTELPTDDAGWDTLALAAVTRARAERRLVPGLGHPVHKVHDPRTPVLIALAEREGLRGPHLRLFEAIGRVHSRVLGRTLPLNGAGVCGAALADLGLPPELLRGFALLARAAGLLGHLAEERRTGIGMEIYRTVDRNARYTPPDPA
>CP028158.1|AVT29522.1|1991024_1992191_-|carnitine-dehydratase
MADQPGTGDTPGPLAGLVVADFSRILAGPYATMLLADLGADVIKVEGPAGDDTRTWMPPVRDGVATYYLGINRNKRSITLDLRSPEDLAVARALAARADVMIENFKPGGMRRFGLDYESVAAENPGIVYASISGFGTGAGAALPGYDLMVQAISGLMSLTGDPDGSPYRAGISVFDVMAGMHANIGILAALHHRTASGRGQHVEVNLLSSALSGLVNHSSGYVAGGVVPYRMGNAHPSLFPYEPLPVADGELIVIAGNDGQFRKLCEVLGLPELVDDPRFGRNQDRTANREELRPLLVERLRTRTRDEWFADLIAAGVPCAPINTIDRGVAFAEQVGLDPVVTLGEGADAVPMVRNPITFSATRPRYDLPPPGLDEHGEEIRAWLTKN

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Crispr_ID: CP028158_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_5

3760668-3760770

Orphan

Consensus_repeat	Method
TCGCCGGCAGGGCCGGGCCGAGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_5

>merge|CP028158|5|3760668-3760770|CRISPRCasFinder
CGGCCGGTAGGGACCAGTCGAGGATTTCGCCGGCAGGGCCGGGCCGAGGATTTGGCCGGGCAGGGCCAAGTTGGGGATCTCGCCGGCAGGGCCGGGGCGAGGA

>CP028158|5|5|3760668-3760770|CRISPRCasFinder
CGGCCGGTAGGGACCAGTCGAGGA	TTTCGCCGGCAGGGCCGGGCCGAGGATTTGGCCGGGCAGGGCCAAGTTGGGGATC
TCGCCGGCAGGGCCGGGGCGAGGA

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT30761.1\|3751311_3751587_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT30767.1\|3760354_3760579_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371308
CP028158.1\|AVT30765.1\|3756669_3758337_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
CP028158.1\|AVT30772.1\|3765664_3766432_-\|UMP-kinase	unknown	unknown	gnl\|CDD\|234735
CP028158.1\|AVT30764.1\|3754289_3756506_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225272
CP028158.1\|AVT34516.1\|3752487_3753231_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277347
CP028158.1\|AVT30760.1\|3749749_3749938_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
CP028158.1\|AVT30770.1\|3763548_3765024_-\|phosphatidate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|366491
CP028158.1\|AVT30769.1\|3762311_3763445_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|184689
CP028158.1\|AVT30775.1\|3769020_3770583_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
CP028158.1\|AVT30766.1\|3758401_3759988_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|225130
CP028158.1\|AVT34515.1\|3749928_3750708_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379262
CP028158.1\|AVT30776.1\|3770906_3771266_+\|YraN-family-protein	unknown	unknown	gnl\|CDD\|237119
CP028158.1\|AVT30773.1\|3766601_3767432_-\|elongation-factor-Ts	unknown	unknown	gnl\|CDD\|236491
CP028158.1\|AVT30774.1\|3767563_3768415_-\|30S-ribosomal-protein-S2	unknown	unknown	gnl\|CDD\|235396
CP028158.1\|AVT30768.1\|3760853_3762209_-\|cell-division-protein-DivIVA	unknown	unknown	gnl\|CDD\|188337
CP028158.1\|AVT30763.1\|3753349_3754054_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|131480
CP028158.1\|AVT30762.1\|3751670_3752213_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379112
CP028158.1\|AVT30771.1\|3765023_3765581_-\|ribosome-recycling-factor	unknown	unknown	gnl\|CDD\|178850
CP028158.1\|AVT30777.1\|3771317_3772427_+\|threonine-aldolase	unknown	unknown	gnl\|CDD\|224919

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT30767.1\|3760354_3760579_+\|hypothetical-protein	gnl\|CDD\|371308	pfam10939, DUF2631, Protein of unknown function (DUF2631). This is s bacterial family of proteins with unknown function.	0.00661928
CP028158.1\|AVT30765.1\|3756669_3758337_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	1.51553e-59
CP028158.1\|AVT30772.1\|3765664_3766432_-\|UMP-kinase	gnl\|CDD\|234735	PRK00358, pyrH, uridylate kinase; Provisional.	1.42368e-130
CP028158.1\|AVT30764.1\|3754289_3756506_-\|hypothetical-protein	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	9.19815e-98
CP028158.1\|AVT34516.1\|3752487_3753231_+\|metallophosphoesterase	gnl\|CDD\|277347	cd07402, MPP_GpdQ, Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain. GpdQ (glycerophosphodiesterase Q, also known as Rv0805 in Mycobacterium tuberculosis) is a binuclear metallophosphoesterase from Enterobacter aerogenes that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. The GpdQ homolog, Rv0805, has 2',3'-cyclic nucleotide phosphodiesterase activity. GpdQ and Rv0805 belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.54192e-55
CP028158.1\|AVT30760.1\|3749749_3749938_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.21577e-23
CP028158.1\|AVT30770.1\|3763548_3765024_-\|phosphatidate-cytidylyltransferase	gnl\|CDD\|366491	pfam01148, CTP_transf_1, Cytidylyltransferase family. The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.	1.80935e-65
CP028158.1\|AVT30769.1\|3762311_3763445_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|184689	PRK14459, PRK14459, ribosomal RNA large subunit methyltransferase N; Provisional.	0
CP028158.1\|AVT30775.1\|3769020_3770583_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.6428e-06
CP028158.1\|AVT30766.1\|3758401_3759988_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	3.82788e-13
CP028158.1\|AVT34515.1\|3749928_3750708_-\|hypothetical-protein	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	0.00153457
CP028158.1\|AVT30776.1\|3770906_3771266_+\|YraN-family-protein	gnl\|CDD\|237119	PRK12497, PRK12497, YraN family protein.	4.90853e-43
CP028158.1\|AVT30773.1\|3766601_3767432_-\|elongation-factor-Ts	gnl\|CDD\|236491	PRK09377, tsf, elongation factor Ts; Provisional.	8.29037e-125
CP028158.1\|AVT30774.1\|3767563_3768415_-\|30S-ribosomal-protein-S2	gnl\|CDD\|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	3.07503e-161
CP028158.1\|AVT30768.1\|3760853_3762209_-\|cell-division-protein-DivIVA	gnl\|CDD\|188337	TIGR03543, divI1A_rptt_fam, DivIVA domain repeat protein. Members of this protein family contain two full and two partial repeats of a domain found at the N-terminus of Bacillus subtilis cell-division initiation protein DivIVA. The portion repeated four times in these proteins includes the motif GYxxxxVD.	6.6127e-08
CP028158.1\|AVT30763.1\|3753349_3754054_+\|alpha/beta-hydrolase	gnl\|CDD\|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	1.36851e-24
CP028158.1\|AVT30762.1\|3751670_3752213_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	3.81769e-26
CP028158.1\|AVT30771.1\|3765023_3765581_-\|ribosome-recycling-factor	gnl\|CDD\|178850	PRK00083, frr, ribosome recycling factor; Reviewed.	9.54631e-101
CP028158.1\|AVT30777.1\|3771317_3772427_+\|threonine-aldolase	gnl\|CDD\|224919	COG2008, GLY1, Threonine aldolase [Amino acid transport and metabolism].	1.3533e-41

>CP028158.1|AVT30767.1|3760354_3760579_+|hypothetical-protein
MAGSEPVTSPDQRKPGNRRAGQIGAIISAAALVLMMFNNNEVSGTAKIWLGAIAAALVLAVVGDVILRRNGLRS
>CP028158.1|AVT30766.1|3758401_3759988_-|(2Fe-2S)-binding-protein
MRLTGTGHASMRIDTGAGSILCDPWVNPAYFASWFPFPDNSQLDWETLGDVDYLYVSHLHRDHFDAAHLKRFISKKATVLLPEYPTSELEDELRELGFTSFLRTRSDEVVELDGGLKVMIQALTSPTDGPIGDSSLWVEYDGVRLLNQNDARPTDLGVFAELGHVHAHLLQFSGAIWYPMVYELPSAAKTAFGKQKRDRQMDRTIRYIDDLKASWVFPIAGPPCFLDDELWQFNDIHGDEGNIFPDQQVFLDHYNSLGYDNGVILLPGSVSEIGTESVHTTHPVPDVREFFEQKEEHLREYQKRARPVIEAAKASWRHPEIDVLAEMKRRIEPLLDESIYLAKGVGGPVRFDLVGYDGETVESILVDFPGKEVRPYADEKVRYRFRTERALVEHLLHIEEVDWVNSLFLSCRFSAARIGQYNEFVYAFFKCLSEERLQYAEGWYDEHERATDAEDITLGDWVVQRRCPHLKADLTRFGIVEENQLTCQLHGWRFDLASGRCLTSVGHSIRAHRVGEAPAPAAESETAG
>CP028158.1|AVT30765.1|3756669_3758337_+|FAD-dependent-oxidoreductase
MTAELPSRADVVIVGAGHNGLVSAILLARAGLDVLVLEGSDTIGGAARTENPFPRVPELRHSTGSYLLGLMPPELIRLLDVRLPVLRRDPHYFLPTPGGPGSPYLLFGADREVTRQQMERFFSRADVAADDAMQAELAALRDDLAPAWLAEPLPVPETADRYIRPALRQVFVDLVRGSVADYLARFDFRSELLVSMYAVTDGLSGLNAGPDDPGTGHNFLAHNMCRLPGAGGTWMIVAGGMGTVSRTFADAARTAGAKLLSGTPVTAITLDGGAVSGVVLDDGRSVATEVVLGAGDPYRLMELVPDGALPAALTERMAAVRRTGTTLKVNLALAGLPDFSCLPEGAPSPFGATIHLLPGSAALLPGSVGSGGSVGSVGSASSAGSVGDAPMAALRGMWADVQAGRLPEEPTIEWYLHTTVDPSLRDAAGHHSSALFVQSVPYAPTGGSWDELLPGYVARLLEICDRYAPGTSELVADAVPLTPPGIEAHFGITGGHIHHVDNTVSFTDRMPYATGVDGLYAGSAGCHPAGSVIGAAGHNAARRILTDLGRVGPAA
>CP028158.1|AVT30764.1|3754289_3756506_-|hypothetical-protein
MFAWWGRAVVRLRWVVLAAGLVLVAVGATWGTGVFGSLTGGGFEDPGSESVRTQERITAELGNQGADLLVLYSSPTSTVDQPAFRDPVTGTLDRLRQHPEVAAVTSWYETQAPALLSTDRHATYAAVRLRATDPDEQAEAYQKLRPALDAPGVTTEAGGTVAFLAEANEQSKKDITRAETLSLPVLLVLLILIFRGLAAAATPLLVGGLAILGAFVAVRLLGMVTDVSVFAINIITLIGLGMAVDYALFVVSRFREELAAGRSSPEAIRRTMSTAGRTVMVSGLTIATALASLLIFPQSFLRSMGLGGMAAVLVAMLAALTVLPALLAVLGPRINSLAVRLPWQRRRDGADPVGAAGVGGSGAWARLARSVMRRPVLYLLGVLAVLAVLAAPSVRMEAGGFDERVLPADAVPRMVAERIESDFPGGSVGPIEVLVSGASAADTQRFADELTRVSGVTGVQVTANRGDSTLLSLTYPGEPTGPVAERVVRLVRDMPAPPGAEVLVGGRPAFDVDLLESLTSRLPLMALIMASATLVLLFLAFGSVLLPIKAVLMNLVSIGASFGVVVWIFQDGHLADWLDFTPTGFIEPSNPILMLAVLFGLATDYEVFLLSRVREEWDATGDNTASVATGLQHTGRIITAAALLLIVVVAGFATGGVVFVKLIGIGMIVAIVVDATLVRALLVPATMRLLGRWNWWAPAPLARVYRRYGIRESRPTSPAAVPDELGATETAPTRPTTA
>CP028158.1|AVT30763.1|3753349_3754054_+|alpha/beta-hydrolase
MNNGSLHTAEANGILLAYRVAGDPARPPMVLLHGLGDDERDWQDVLPHLAEDHRVYALDLRGHGRSARPGHYSFELMCNDVISFLDVIGIERCVLIGHSMGAVVATLVAQTAAHRLTHLVLEDATPPRPGDLARPPLAAPDEPTPYDFAAVNAVRKQLDDPDPAWWDGTAVVNVPTLIVGGAHSSIPQSLLAATADRMPDATLVTIAAGHYVHQERPAEFLAAVDGFLAARPVK
>CP028158.1|AVT34516.1|3752487_3753231_+|metallophosphoesterase
MSIIAHISDTHFDGSERALARSRRIMAYLRGCDVDVILVTGDLTDNGDVKEYEQVKTELVADVPVLLLPGNHDDRAAYRKVLLDDDGTAPINQLHRAGGMSFALCDSTIPGQHEGLLAPETLDWLQGVLAEAEEPVFICLHHHPIRLNHPLLDSIRLRNPEELAAVVSASSTATAVLCGHAHAAATGTFAGLPLIAAPGIFSTTRLPWTTTDELTWSNTFDRDDVPGLVFHVLEDGQLTSHFRSVAA
>CP028158.1|AVT30762.1|3751670_3752213_-|GNAT-family-N-acetyltransferase
MTIYETERLVVRDWTLEPDDLARVFDTYSRPEVVRFLGAPIFPLREPADAAETVRRWHARNATFGAGYGIWAAQRREDGLVVGTVMLKPLPGRDETKLTDDIEVGWHLHPDSWGHGYATEAARGAVERGFAAGVPEIYAVVAPGNEASMAVARRIGMASVGRRTDWYGGEELETFRLSRQ
>CP028158.1|AVT30761.1|3751311_3751587_+|hypothetical-protein
MNPATRPPSARPHLPLRPLWICRTCGQPWPCAVARLTLLADYRDDLVGLHVYLGAALFAATADLYRLNPHPGPDPAALFARFLGWARPHRS
>CP028158.1|AVT34515.1|3749928_3750708_-|hypothetical-protein
MFAGELRRFRGVAGLSQDGLAHRINFSSALVAKIELCQRRPTREFAKRCDGVLDTGGLLERIQAVLGPGPVMPWFRHWVIAEQEATDIRCFQLSVIPGLLQTEAYARALLASGGLLTAEQVEEQVATRLARQEILSRPDPPMFTAVLDERVLHQPVGGAEVMRDQLRHIVKLCAEQPRVRIQVVPTSVGAYAGLNGPFVIVTHPGGDDVAYLDDQLDGRFVERAGDVKTVQQLWDSVRAEALSHQQSIEMIREVAESWN
>CP028158.1|AVT30760.1|3749749_3749938_-|DUF397-domain-containing-protein
MELNGALWRKSSRSNGHGGECVEVAGNLPGVVGVRDSKDPAGPVLTFAPPAWRSFVRTLRAR
>CP028158.1|AVT30768.1|3760853_3762209_-|cell-division-protein-DivIVA
MASQGQRFRRKALRRGYKVDEVDTFLDRVEATLAGEPLGAPVASQEVHDVVFRVRFGGYDEWQVDLHLDRVERQIAELEERGGGRGGDPRLSDRGAPDRMGPPDRMGPPDRLGPPDRMGPPDRMGPPDRMGPPMRDDRGLPPGQLPGRPMPAQAGPPNDPYGQYDEPTGTFGGGFGGQRGGFDPQRGGMEPQRGGFDPQRGGFEPQRGGFDPQRGGMEPQRGGFEPQRGGFDPQRGGFEPQRGGFDPQRGGMEPQRGGFDPQRGGFDPQRGPGAPLPPRTPSGPGGPPGGFGANERFDGFDAGRPSRADMTAEIRMPDRDPRGSGRGMGDALPPMPAPAGGPPMGGPPMGGPPPGGPGLGGPPLMGPPGSDMARIDHIRRSFQVRRFGSGYDPDQVDRLFEGILGSMAGRGPMPVNPSDLDTTRFGLVPGGYFEAEVDAALKEVKDLLLGQ
>CP028158.1|AVT30769.1|3762311_3763445_-|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MTSLPLIQITPDDSTGSPSRRAAMPPRHLADLDLPARQAAVAELGEPAFRARQVSTHYFGRLVRDPARMTDLPAAARDRIATELLPSLLTPVREVATDDGATRKALWRLHDGSLVESVLMGYPDRVTVCISSQAGCGMACPFCATGQAGLTRNLSTAEIVDQAVYLAGVAASGAIAGSPSRLSHVVFMGMGEPLANYARVVSAVRRLTAPAPEGLGLSQRHVTVSTVGLVPAMRRLADEGLSVTLALSLHAPDDELRDELVPVNQRWKVAEVLDAAWHYAERTGRRVSIEYAMIRDVNDQPWRADLLGRLLAGRLTHVNLIPLNPTPGSRWDASPKPVEREFVRRLRAAGVSTTVRDTRGREIDGACGQLAAAAVTR
>CP028158.1|AVT30770.1|3763548_3765024_-|phosphatidate-cytidylyltransferase
MSHVDPYGGTAEPRGRQRPEQARGPEWSRGPGYPDGPSGRQRPAGDDDAWARARHGGAAPDAYSAPTDSYPVASDSYPAAPEAYPSPEAYPSPADAYRGAPNGYPGTAADGFSGVDRGPGGATGQRNGQPAGDVPDSTAQWRSPWRSPEPAGGPAGPEEDAAVYRDRTDHPGAEPAADAPTNPVGWPLVDPDPQPAADPASSARPGRGRRRATRSGKPAGQSRAGRNLPAAIGVGLGLGAAIVVPLFLLRPAFLLVVALAVSVGIWEMTRAVRPAGMRPPLVPLVAGGLLMVGLAWWAGPDALSLGLLVTVLATMVWRLGDGPAGYQRDMTAATLIAVYVPFLGGFAALLAAEPVDGDLRVLATLAAVVLSDTGGYAAGVAFGKHPMAPSVSPKKSWEGFAGSVLAAAVGSSLLLAYLLDVELWWGALFGVAVSIAAVLGDLAESMIKRDLKVKDMSNLLPGHGGLMDRLDSILFAVPTAYLLLAIFAPAG
>CP028158.1|AVT30771.1|3765023_3765581_-|ribosome-recycling-factor
MIDDTLLEAEEKMERAVEHAKEEFGAIRTGRATPAMFSKIIIDYYGSPTPLTQMASVGVPEPRMAIIKPYDASQLHAMEKAIRDSDLGVNPNNEGNQLRILLPQMTEERRRDMIKVARHKGEEAKVAIRNIRRRGKEELDRIVKDGEAGEDDGRRAEKELDDLTHKYVSHVDELVKHKETELLEV
>CP028158.1|AVT30772.1|3765664_3766432_-|UMP-kinase
MTQVVSDRTLAADDPTAPPPGRARRVVLKLSGEVFGGGAIGVDPDVVQAIARQIATVVRRGVQVSVVVGGGNFFRGAELQKRGMDRARADYMGMLGTVMNCLALQDFLEKEGIETRVQSAITMAQVAEPYIPLRAIRHLEKGRVVIFGAGAGMPYFSTDTVAAQRALEIRADVVLMSKNGVDGVYTADPRTDPDASKLDKITFSEVLRRGLRVADAAAFSLCEENGLPMLVFGAEGDDTIIRAVAGEPIGTLITT
>CP028158.1|AVT30773.1|3766601_3767432_-|elongation-factor-Ts
MSNFTAADVKKLRDLTGAGMMDCKKALTEAEGDFDKAVEVLRVKGVKDVGKRAGRTAANGLVAHSGKALLELNCETDFVAKNSDFIAFAQLLVEHGAQAGVADAEALLGSTLPDGRTVADAVQEQSAKIGEKLVLNRFAAVDGTAAVYLHRKAQDLPPQVGVLVEYTGKADEAGDADARAVAMQIAAMRPKYLTRDEVPAETVASERRIAEQTAREEGKPEAALPKIIEGRVNAFFKDYVLIEQASVADNKKSVKQVLAEAGIEVTRFVRFEVGQA
>CP028158.1|AVT30774.1|3767563_3768415_-|30S-ribosomal-protein-S2
MAVVTMRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLRQTLDYIEKAYEFVRGTVAEGGSILFVGTKKQAQEAIAEQATRVGQPFVNHRWLGGMLTNFQTVYKRLQRMKELEALGDLSGTAQGYTKKETLQLSREKDKLTRTLGGLRDMQKVPAAIWVVDTKKEHIAVDEARKLGIPVIAVLDTNCDPDEVDFPIPGNDDAIRSAELLTKVIAAAVGDGLIARSGKRRGTDEKPEPGVVGADEPLAEWERELIEDTEKKAAGEAEQKAGEPAGVAAE
>CP028158.1|AVT30775.1|3769020_3770583_-|hypothetical-protein
MAVEQQRNFPEEQRSGWRPDDRGYPDQRWHGVGEDRYPGTEQPAAPAPLGGPAPDRPYGQPVDAGTGRYADPPRFGVPERSAGPAPYAPDPHGGNPPGGGFPGFVPAGPADPAPPSLEVPLPSFGAAPTGAGAGYPSSGWATDPTTQRGVTATGAADATGPVQSTEGPSHLPVGTGHDAVAAGPNGSDEARAGGWHGAAPTGHDAAPDEARVGGWHGAASAVAEGRLGGRHDAGPLGSDEGWGAGRHSVAAAEPGQPVGTVTDSGHPSMSVDPGRSPLSGYPIVQPARIAEAGHPGEAGPPAPGGEPGRAGGAAQPGRAGEAVQSGRGAEAVQSGRGAEVGQPGHGTDRGGALDQPTNLVPQVDPRAGTGGVPVGVDPSGQHGESIDRTAALRPTTAAPPGQPGSGPAGLPGGLGLPAGDGVYRTRRPALAVVLALLAVVFEVPAVRLLLDGALGDPVLPSAVLSGTFLVLGLPIFAAGLYGLATSAAALADPARAWLRPPTGYLTIGLVLFVAAALAAG
>CP028158.1|AVT30776.1|3770906_3771266_+|YraN-family-protein
MTAARQAVGAYGERCAVRHLVEAGLRVVVRNWRCAHGEIDIIAWEGNVLAFCEVKTRRSDAFGTPAEAVVGRKAGRLRRLAAEWLRTSGVHPEQIRFDVVEVYPARSGPARVEHLRAAF
>CP028158.1|AVT30777.1|3771317_3772427_+|threonine-aldolase
MPSSESRAHPATASSIRRSLFLHAPIHRMPRAVLHEMLDQLDDDTPPGGPDAPVARMERRIADLFGTESALFFPTGTMAQQVALRIHAERRGRHAFAAHPQSHLDVWEQRGYHVVHGLRFHPVGDRHALMTDAALAAIGEPLAAVVWELPQRDIGGQLPEWDELREQVAAVRARGAAAHLDGARIWEAQTYYRRPFAEIAGLFDTVYTSLYKALLGIRGAVLAADAATIAEATVWRSRLGGAIHDAWPLALAGLAGLDRLLPQMPAFREHAIAIATAINSDGVALAWPDPPQTPIFHVHLPASRQDVERAGEEMIAEHGVQLFPRVRSAADPTRCSFEVTVGEQAMAFSPDEVVALLHELLDRAGGRQP

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Crispr_ID: CP028158_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_6

3768767-3768837

Orphan

Consensus_repeat	Method
GCCGCCGGGTGTCCGGCGGCCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_6

>merge|CP028158|6|3768767-3768837|CRISPRCasFinder
GCCGCCGGGTGTCCGGCGGCCGCGAGGTTTCGCACCGCCTGGCCCGCTGCCGCCGGGTGTCCGGCCGCCGC

>CP028158|6|6|3768767-3768837|CRISPRCasFinder
GCCGCCGGGTGTCCGGCGGCCGC	GAGGTTTCGCACCGCCTGGCCCGCT
GCCGCCGGGTGTCCGGCCGCCGC

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT30767.1\|3760354_3760579_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371308
CP028158.1\|AVT30765.1\|3756669_3758337_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|224154
CP028158.1\|AVT30772.1\|3765664_3766432_-\|UMP-kinase	unknown	unknown	gnl\|CDD\|234735
CP028158.1\|AVT30781.1\|3778153_3778960_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366703
CP028158.1\|AVT30783.1\|3780959_3781283_-\|DUF2469-domain-containing-protein	unknown	unknown	gnl\|CDD\|313765
CP028158.1\|AVT30770.1\|3763548_3765024_-\|phosphatidate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|366491
CP028158.1\|AVT30769.1\|3762311_3763445_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	unknown	unknown	gnl\|CDD\|184689
CP028158.1\|AVT34517.1\|3774462_3775662_+\|DNA-processing-protein-DprA	unknown	unknown	gnl\|CDD\|376794
CP028158.1\|AVT30775.1\|3769020_3770583_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
CP028158.1\|AVT30766.1\|3758401_3759988_-\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|225130
CP028158.1\|AVT30779.1\|3775874_3776828_+\|integrase	unknown	unknown	gnl\|CDD\|234698
CP028158.1\|AVT30776.1\|3770906_3771266_+\|YraN-family-protein	unknown	unknown	gnl\|CDD\|237119
CP028158.1\|AVT30773.1\|3766601_3767432_-\|elongation-factor-Ts	unknown	unknown	gnl\|CDD\|236491
CP028158.1\|AVT30768.1\|3760853_3762209_-\|cell-division-protein-DivIVA	unknown	unknown	gnl\|CDD\|188337
CP028158.1\|AVT30774.1\|3767563_3768415_-\|30S-ribosomal-protein-S2	unknown	unknown	gnl\|CDD\|235396
CP028158.1\|AVT30778.1\|3772771_3774292_+\|Mg-chelatase-like-protein	unknown	unknown	gnl\|CDD\|223679
CP028158.1\|AVT30782.1\|3779383_3780625_+\|sulfite-oxidase	unknown	unknown	gnl\|CDD\|239028
CP028158.1\|AVT30771.1\|3765023_3765581_-\|ribosome-recycling-factor	unknown	unknown	gnl\|CDD\|178850
CP028158.1\|AVT30780.1\|3776944_3778135_+\|aminotransferase	unknown	unknown	gnl\|CDD\|223594
CP028158.1\|AVT30777.1\|3771317_3772427_+\|threonine-aldolase	unknown	unknown	gnl\|CDD\|224919

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT30767.1\|3760354_3760579_+\|hypothetical-protein	gnl\|CDD\|371308	pfam10939, DUF2631, Protein of unknown function (DUF2631). This is s bacterial family of proteins with unknown function.	0.00661928
CP028158.1\|AVT30765.1\|3756669_3758337_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	1.51553e-59
CP028158.1\|AVT30772.1\|3765664_3766432_-\|UMP-kinase	gnl\|CDD\|234735	PRK00358, pyrH, uridylate kinase; Provisional.	1.42368e-130
CP028158.1\|AVT30781.1\|3778153_3778960_-\|hypothetical-protein	gnl\|CDD\|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.07944e-17
CP028158.1\|AVT30783.1\|3780959_3781283_-\|DUF2469-domain-containing-protein	gnl\|CDD\|313765	pfam10611, DUF2469, Protein of unknown function (DUF2469). Member proteins often found in Actinomycetes clustered with signal peptidase and/or RNAse-HII.	2.59855e-63
CP028158.1\|AVT30770.1\|3763548_3765024_-\|phosphatidate-cytidylyltransferase	gnl\|CDD\|366491	pfam01148, CTP_transf_1, Cytidylyltransferase family. The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.	1.80935e-65
CP028158.1\|AVT30769.1\|3762311_3763445_-\|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN	gnl\|CDD\|184689	PRK14459, PRK14459, ribosomal RNA large subunit methyltransferase N; Provisional.	0
CP028158.1\|AVT34517.1\|3774462_3775662_+\|DNA-processing-protein-DprA	gnl\|CDD\|376794	pfam02481, DNA_processg_A, DNA recombination-mediator protein A. The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyze the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation.	5.9254e-78
CP028158.1\|AVT30775.1\|3769020_3770583_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.6428e-06
CP028158.1\|AVT30766.1\|3758401_3759988_-\|(2Fe-2S)-binding-protein	gnl\|CDD\|225130	COG2220, COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only].	3.82788e-13
CP028158.1\|AVT30779.1\|3775874_3776828_+\|integrase	gnl\|CDD\|234698	PRK00236, xerC, site-specific tyrosine recombinase XerC; Reviewed.	2.00166e-126
CP028158.1\|AVT30776.1\|3770906_3771266_+\|YraN-family-protein	gnl\|CDD\|237119	PRK12497, PRK12497, YraN family protein.	4.90853e-43
CP028158.1\|AVT30773.1\|3766601_3767432_-\|elongation-factor-Ts	gnl\|CDD\|236491	PRK09377, tsf, elongation factor Ts; Provisional.	8.29037e-125
CP028158.1\|AVT30768.1\|3760853_3762209_-\|cell-division-protein-DivIVA	gnl\|CDD\|188337	TIGR03543, divI1A_rptt_fam, DivIVA domain repeat protein. Members of this protein family contain two full and two partial repeats of a domain found at the N-terminus of Bacillus subtilis cell-division initiation protein DivIVA. The portion repeated four times in these proteins includes the motif GYxxxxVD.	6.6127e-08
CP028158.1\|AVT30774.1\|3767563_3768415_-\|30S-ribosomal-protein-S2	gnl\|CDD\|235396	PRK05299, rpsB, 30S ribosomal protein S2; Provisional.	3.07503e-161
CP028158.1\|AVT30778.1\|3772771_3774292_+\|Mg-chelatase-like-protein	gnl\|CDD\|223679	COG0606, COG0606, Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones].	8.47626e-180
CP028158.1\|AVT30782.1\|3779383_3780625_+\|sulfite-oxidase	gnl\|CDD\|239028	cd02110, SO_family_Moco_dimer, Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). .	4.26037e-101
CP028158.1\|AVT30771.1\|3765023_3765581_-\|ribosome-recycling-factor	gnl\|CDD\|178850	PRK00083, frr, ribosome recycling factor; Reviewed.	9.54631e-101
CP028158.1\|AVT30780.1\|3776944_3778135_+\|aminotransferase	gnl\|CDD\|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	6.35023e-40
CP028158.1\|AVT30777.1\|3771317_3772427_+\|threonine-aldolase	gnl\|CDD\|224919	COG2008, GLY1, Threonine aldolase [Amino acid transport and metabolism].	1.3533e-41

>CP028158.1|AVT30774.1|3767563_3768415_-|30S-ribosomal-protein-S2
MAVVTMRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLRQTLDYIEKAYEFVRGTVAEGGSILFVGTKKQAQEAIAEQATRVGQPFVNHRWLGGMLTNFQTVYKRLQRMKELEALGDLSGTAQGYTKKETLQLSREKDKLTRTLGGLRDMQKVPAAIWVVDTKKEHIAVDEARKLGIPVIAVLDTNCDPDEVDFPIPGNDDAIRSAELLTKVIAAAVGDGLIARSGKRRGTDEKPEPGVVGADEPLAEWERELIEDTEKKAAGEAEQKAGEPAGVAAE
>CP028158.1|AVT30773.1|3766601_3767432_-|elongation-factor-Ts
MSNFTAADVKKLRDLTGAGMMDCKKALTEAEGDFDKAVEVLRVKGVKDVGKRAGRTAANGLVAHSGKALLELNCETDFVAKNSDFIAFAQLLVEHGAQAGVADAEALLGSTLPDGRTVADAVQEQSAKIGEKLVLNRFAAVDGTAAVYLHRKAQDLPPQVGVLVEYTGKADEAGDADARAVAMQIAAMRPKYLTRDEVPAETVASERRIAEQTAREEGKPEAALPKIIEGRVNAFFKDYVLIEQASVADNKKSVKQVLAEAGIEVTRFVRFEVGQA
>CP028158.1|AVT30772.1|3765664_3766432_-|UMP-kinase
MTQVVSDRTLAADDPTAPPPGRARRVVLKLSGEVFGGGAIGVDPDVVQAIARQIATVVRRGVQVSVVVGGGNFFRGAELQKRGMDRARADYMGMLGTVMNCLALQDFLEKEGIETRVQSAITMAQVAEPYIPLRAIRHLEKGRVVIFGAGAGMPYFSTDTVAAQRALEIRADVVLMSKNGVDGVYTADPRTDPDASKLDKITFSEVLRRGLRVADAAAFSLCEENGLPMLVFGAEGDDTIIRAVAGEPIGTLITT
>CP028158.1|AVT30771.1|3765023_3765581_-|ribosome-recycling-factor
MIDDTLLEAEEKMERAVEHAKEEFGAIRTGRATPAMFSKIIIDYYGSPTPLTQMASVGVPEPRMAIIKPYDASQLHAMEKAIRDSDLGVNPNNEGNQLRILLPQMTEERRRDMIKVARHKGEEAKVAIRNIRRRGKEELDRIVKDGEAGEDDGRRAEKELDDLTHKYVSHVDELVKHKETELLEV
>CP028158.1|AVT30770.1|3763548_3765024_-|phosphatidate-cytidylyltransferase
MSHVDPYGGTAEPRGRQRPEQARGPEWSRGPGYPDGPSGRQRPAGDDDAWARARHGGAAPDAYSAPTDSYPVASDSYPAAPEAYPSPEAYPSPADAYRGAPNGYPGTAADGFSGVDRGPGGATGQRNGQPAGDVPDSTAQWRSPWRSPEPAGGPAGPEEDAAVYRDRTDHPGAEPAADAPTNPVGWPLVDPDPQPAADPASSARPGRGRRRATRSGKPAGQSRAGRNLPAAIGVGLGLGAAIVVPLFLLRPAFLLVVALAVSVGIWEMTRAVRPAGMRPPLVPLVAGGLLMVGLAWWAGPDALSLGLLVTVLATMVWRLGDGPAGYQRDMTAATLIAVYVPFLGGFAALLAAEPVDGDLRVLATLAAVVLSDTGGYAAGVAFGKHPMAPSVSPKKSWEGFAGSVLAAAVGSSLLLAYLLDVELWWGALFGVAVSIAAVLGDLAESMIKRDLKVKDMSNLLPGHGGLMDRLDSILFAVPTAYLLLAIFAPAG
>CP028158.1|AVT30769.1|3762311_3763445_-|23S-rRNA-(adenine(2503)-C(2))-methyltransferase-RlmN
MTSLPLIQITPDDSTGSPSRRAAMPPRHLADLDLPARQAAVAELGEPAFRARQVSTHYFGRLVRDPARMTDLPAAARDRIATELLPSLLTPVREVATDDGATRKALWRLHDGSLVESVLMGYPDRVTVCISSQAGCGMACPFCATGQAGLTRNLSTAEIVDQAVYLAGVAASGAIAGSPSRLSHVVFMGMGEPLANYARVVSAVRRLTAPAPEGLGLSQRHVTVSTVGLVPAMRRLADEGLSVTLALSLHAPDDELRDELVPVNQRWKVAEVLDAAWHYAERTGRRVSIEYAMIRDVNDQPWRADLLGRLLAGRLTHVNLIPLNPTPGSRWDASPKPVEREFVRRLRAAGVSTTVRDTRGREIDGACGQLAAAAVTR
>CP028158.1|AVT30768.1|3760853_3762209_-|cell-division-protein-DivIVA
MASQGQRFRRKALRRGYKVDEVDTFLDRVEATLAGEPLGAPVASQEVHDVVFRVRFGGYDEWQVDLHLDRVERQIAELEERGGGRGGDPRLSDRGAPDRMGPPDRMGPPDRLGPPDRMGPPDRMGPPDRMGPPMRDDRGLPPGQLPGRPMPAQAGPPNDPYGQYDEPTGTFGGGFGGQRGGFDPQRGGMEPQRGGFDPQRGGFEPQRGGFDPQRGGMEPQRGGFEPQRGGFDPQRGGFEPQRGGFDPQRGGMEPQRGGFDPQRGGFDPQRGPGAPLPPRTPSGPGGPPGGFGANERFDGFDAGRPSRADMTAEIRMPDRDPRGSGRGMGDALPPMPAPAGGPPMGGPPMGGPPPGGPGLGGPPLMGPPGSDMARIDHIRRSFQVRRFGSGYDPDQVDRLFEGILGSMAGRGPMPVNPSDLDTTRFGLVPGGYFEAEVDAALKEVKDLLLGQ
>CP028158.1|AVT30767.1|3760354_3760579_+|hypothetical-protein
MAGSEPVTSPDQRKPGNRRAGQIGAIISAAALVLMMFNNNEVSGTAKIWLGAIAAALVLAVVGDVILRRNGLRS
>CP028158.1|AVT30766.1|3758401_3759988_-|(2Fe-2S)-binding-protein
MRLTGTGHASMRIDTGAGSILCDPWVNPAYFASWFPFPDNSQLDWETLGDVDYLYVSHLHRDHFDAAHLKRFISKKATVLLPEYPTSELEDELRELGFTSFLRTRSDEVVELDGGLKVMIQALTSPTDGPIGDSSLWVEYDGVRLLNQNDARPTDLGVFAELGHVHAHLLQFSGAIWYPMVYELPSAAKTAFGKQKRDRQMDRTIRYIDDLKASWVFPIAGPPCFLDDELWQFNDIHGDEGNIFPDQQVFLDHYNSLGYDNGVILLPGSVSEIGTESVHTTHPVPDVREFFEQKEEHLREYQKRARPVIEAAKASWRHPEIDVLAEMKRRIEPLLDESIYLAKGVGGPVRFDLVGYDGETVESILVDFPGKEVRPYADEKVRYRFRTERALVEHLLHIEEVDWVNSLFLSCRFSAARIGQYNEFVYAFFKCLSEERLQYAEGWYDEHERATDAEDITLGDWVVQRRCPHLKADLTRFGIVEENQLTCQLHGWRFDLASGRCLTSVGHSIRAHRVGEAPAPAAESETAG
>CP028158.1|AVT30765.1|3756669_3758337_+|FAD-dependent-oxidoreductase
MTAELPSRADVVIVGAGHNGLVSAILLARAGLDVLVLEGSDTIGGAARTENPFPRVPELRHSTGSYLLGLMPPELIRLLDVRLPVLRRDPHYFLPTPGGPGSPYLLFGADREVTRQQMERFFSRADVAADDAMQAELAALRDDLAPAWLAEPLPVPETADRYIRPALRQVFVDLVRGSVADYLARFDFRSELLVSMYAVTDGLSGLNAGPDDPGTGHNFLAHNMCRLPGAGGTWMIVAGGMGTVSRTFADAARTAGAKLLSGTPVTAITLDGGAVSGVVLDDGRSVATEVVLGAGDPYRLMELVPDGALPAALTERMAAVRRTGTTLKVNLALAGLPDFSCLPEGAPSPFGATIHLLPGSAALLPGSVGSGGSVGSVGSASSAGSVGDAPMAALRGMWADVQAGRLPEEPTIEWYLHTTVDPSLRDAAGHHSSALFVQSVPYAPTGGSWDELLPGYVARLLEICDRYAPGTSELVADAVPLTPPGIEAHFGITGGHIHHVDNTVSFTDRMPYATGVDGLYAGSAGCHPAGSVIGAAGHNAARRILTDLGRVGPAA
>CP028158.1|AVT30775.1|3769020_3770583_-|hypothetical-protein
MAVEQQRNFPEEQRSGWRPDDRGYPDQRWHGVGEDRYPGTEQPAAPAPLGGPAPDRPYGQPVDAGTGRYADPPRFGVPERSAGPAPYAPDPHGGNPPGGGFPGFVPAGPADPAPPSLEVPLPSFGAAPTGAGAGYPSSGWATDPTTQRGVTATGAADATGPVQSTEGPSHLPVGTGHDAVAAGPNGSDEARAGGWHGAAPTGHDAAPDEARVGGWHGAASAVAEGRLGGRHDAGPLGSDEGWGAGRHSVAAAEPGQPVGTVTDSGHPSMSVDPGRSPLSGYPIVQPARIAEAGHPGEAGPPAPGGEPGRAGGAAQPGRAGEAVQSGRGAEAVQSGRGAEVGQPGHGTDRGGALDQPTNLVPQVDPRAGTGGVPVGVDPSGQHGESIDRTAALRPTTAAPPGQPGSGPAGLPGGLGLPAGDGVYRTRRPALAVVLALLAVVFEVPAVRLLLDGALGDPVLPSAVLSGTFLVLGLPIFAAGLYGLATSAAALADPARAWLRPPTGYLTIGLVLFVAAALAAG
>CP028158.1|AVT30776.1|3770906_3771266_+|YraN-family-protein
MTAARQAVGAYGERCAVRHLVEAGLRVVVRNWRCAHGEIDIIAWEGNVLAFCEVKTRRSDAFGTPAEAVVGRKAGRLRRLAAEWLRTSGVHPEQIRFDVVEVYPARSGPARVEHLRAAF
>CP028158.1|AVT30777.1|3771317_3772427_+|threonine-aldolase
MPSSESRAHPATASSIRRSLFLHAPIHRMPRAVLHEMLDQLDDDTPPGGPDAPVARMERRIADLFGTESALFFPTGTMAQQVALRIHAERRGRHAFAAHPQSHLDVWEQRGYHVVHGLRFHPVGDRHALMTDAALAAIGEPLAAVVWELPQRDIGGQLPEWDELREQVAAVRARGAAAHLDGARIWEAQTYYRRPFAEIAGLFDTVYTSLYKALLGIRGAVLAADAATIAEATVWRSRLGGAIHDAWPLALAGLAGLDRLLPQMPAFREHAIAIATAINSDGVALAWPDPPQTPIFHVHLPASRQDVERAGEEMIAEHGVQLFPRVRSAADPTRCSFEVTVGEQAMAFSPDEVVALLHELLDRAGGRQP
>CP028158.1|AVT30778.1|3772771_3774292_+|Mg-chelatase-like-protein
MSYAKVLCVGLVGVTGHVVEVEADLATGLPTVVLSGLPDTALNEARDRVRAAIVNSGQRWPNRRITVNLLPATLPKHGSAFDLAIAAALLGGSGEMPLAPLDRVAVLGELGLDGTVRPVRGVLPMVVAAVRAGITRVVVPLDNAAEASVVPGVRVRAVDTLHRLVAFIRDGTPLLDPPSPPATSPRPGPDLADVAGQGLGRRALEVAAAGGHHLALFGPPGAGKTMLAERLPSILPELDDEGALEVTALHSIAGLLPPDGQLLRRPPFQAPHHTATIASLVGGGSGLARPGAVSLAHRGVLFLDEAPEFVRGALEALRQPLESGRIVLARSRGGTEYPARVQLVVAANPCPCAKPSGDISCECTPLARRRYLGRLSGPLLDRLDVQVRVSPLRAAELMAAEQTVESSAVVAERVGKARAAAAARWAAGGWRVNAEVPGPQLRHPRWRLPANDTHALRRLLDSGVLSARGFDRVIRLAWSIADLDGRQRPDAGDVDEATQLRTGSLA
>CP028158.1|AVT34517.1|3774462_3775662_+|DNA-processing-protein-DprA
MDEERLARIALTWLFEPGTRAVVRLVREFGAAGALRHLLAGKVSDHRLRATVESRLAAGDPWQVALDAAEQTERLGARVVIPTDPEWPTRLRSLDQLTLSGTDRRVDQETAPPLCFWVRGAWPLGEALQRSVAVVGSRAATPYGLHVATEIAFGLAERDWTVVSGGAFGIDAAAHRGALNAGGLTVAVLACGVDRPYPVGNTALFDRIADVGLLVSEWPPGAEPLRPRFLIRNRVIAAATAGTLVVEAAARSGATQTLRRAIAMKRPSMVVPGPVTSAMSVGAHELLREYPEARLVTGVPHVLEEVGRIGADLAPPVRGPERPQDGLDDDSALILESVPRRRPAGPDVLAARTGLDLRTALRKLSLLEQLGLVLRRDDGFLLAPAATRSGRAASARPAR
>CP028158.1|AVT30779.1|3775874_3776828_+|integrase
MSEPSRSTRARHEALTPAFRESVDDFAQHLASVENRSTHTVRAYVADVVSLLDHAGRMGCTEPGELDITVLRSWLAKLRTLGAARASLARRAASARTFTGWAHRAGLVNTDIGAQLASPRAHRELPAVLRPDQASELVDAPGEVGSPESSRDRVVLELLYATGIRVGELCGLDLGDVDQARRVLRVLGKGAKERTVPYGLPAQRALDDWLRIGRPHLAGPESGTALLLGVRGGRLQPTVVRRIVADYARATGLPRISPHGLRHSAATHLLEGGADLRTVQELLGHATLSSTQIYTHVSVERLRAAYRQAHPRADSPS
>CP028158.1|AVT30780.1|3776944_3778135_+|aminotransferase
MSTAGPQPPVPIPGARLLFSLDPGVAHLNHGSYGAVPIGVQRAQQRLRDETEANPMRFFNRGLVDRITHARRHLAGFLGADPDGTALVGNVTLGAAVVLQSLRLEPGDEVVDTDHGYGSFGLSIQREARRTGAVRRTLTVPLTATDEEIVEIVRAGIRPGRTKLLIVDQLTSATARLFPAAAIAAVARERDVPVLVDGAHAPGMLSTPVQSIGADFWIGNLHKWGYAPRGTAALVVAPRWRNRIEPLAVSWEQETGFPTRVEWQATLDYTPWLAAPVGVFTLRTLGLERVRAHNAELAAYGQRVVGAALGVAPADLVDPGGPTVSMRILPLPPGVATTFPDAVALRQRISDELGAEVNVNPWRDRGWLRLSGQIYNRAEEYDRLAERLPGLLGTLT
>CP028158.1|AVT30781.1|3778153_3778960_-|hypothetical-protein
MTRRWHGAGPAILLSVLLLTLAPPPPAGGAPTGGSIRGAGAPAPITGADQPSTGPSLVWARSQVRTAGLSRWSASAAAAASAAVAPAAVAPAAAAPVSAPVSVSVSAVVSASVSVPVPVPGRFRWPLDGVPPVVRRFDPPPRPWAAGHRGVDLAAPPGATVRAAGPGVVFFAGMVAGRPLVSVAHANGLRTTYEPVRSGLAAGDAVRAGDPLGVLLPGHRGCLSAGSVCLHWGLRRGDEYLDPLLLLGLGRVRLLPVAAPFPAGAAGR
>CP028158.1|AVT30782.1|3779383_3780625_+|sulfite-oxidase
MTTVDDVSRPSRLADPDEGISIEELGLAARNHALPLEALRYDVTPVGLHYLLIHYDIPDLDPGRHLLTVDGQVDRPLTLDLAALRERPRVTRRVTLECAGNGRALLTPRPVSQPWLSEAVGTAEWTGTPLAPLLREAGLGSDAVDVVFTGADHGVERGIEQDYQRGLPVAEALREEVLLAYEMNGLPLLPQHGAPLRLVVPGWYGMAHVKWLTRITVLDREFDGYQNAVAYRLRTSADDPGVPVTRIEPRALVQPPGFPDFMSRTRVLRPGLCTVEGRAWSGHAPVTAVEVTTDGGLSWAPATLEPATGAAELVNGADPDSAGQQESAGQRESAGQRESAGQRESAARGPAVDERWAWRRWRYEWPATPGRYTLGARATDASGRTQPIEQPWNRGGFANNLVQRVEVVVTEDH
>CP028158.1|AVT30783.1|3780959_3781283_-|DUF2469-domain-containing-protein
MSAEDLEKYETEMELQLYREYRDIVRQFSYVVETERRFYLANQVDLHVRNSDGEVYFEVEMHDAWVWDMYRPARFVKNVRVMTFKDVNVEELEKPDISLPADSGFGG

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Crispr_ID: CP028158_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_8

5318438-5318536

Unclear

Consensus_repeat	Method
GCGGCGGACCGGCCGGGTCGATCG	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of CP028158_8

>merge|CP028158|8|5318438-5318536|CRISPRCasFinder
GCGGCGGACCGGCCGGGTCGATCGCCGCAGCGCGGCGGACCGGGCGGACCGATCGCCGCACCCCGACGCCGCGGCGCGGCGGACCGGGCGGGTCGATCG

>CP028158|8|8|5318438-5318536|CRISPRCasFinder
GCGGCGGACCGGCCGGGTCGATCG	CCGCAGCGCGGCGGACCGGGCGGACCGATCGCCGCACCCCGACGCCGCGGC
GCGGCGGACCGGGCGGGTCGATCG

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT31900.1\|5326167_5327475_+\|Bcr/CflA-family-drug-resistance-efflux-transporter	unknown	unknown	gnl\|CDD\|340878
CP028158.1\|AVT31890.1\|5316948_5317530_-\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	unknown	unknown	gnl\|CDD\|235365
CP028158.1\|AVT31891.1\|5317813_5318302_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|319351
CP028158.1\|AVT31898.1\|5323694_5324210_-\|shikimate-kinase	unknown	unknown	gnl\|CDD\|234654
CP028158.1\|AVT31893.1\|5319337_5319895_-\|elongation-factor-P	unknown	unknown	gnl\|CDD\|234788
CP028158.1\|AVT31884.1\|5306932_5307775_-\|orotidine-5'-phosphate-decarboxylase	unknown	unknown	gnl\|CDD\|234651
CP028158.1\|AVT31887.1\|5310277_5313601_-\|carbamoyl-phosphate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|235393
CP028158.1\|AVT31895.1\|5320396_5321473_-\|3-dehydroquinate-synthase	unknown	unknown	gnl\|CDD\|234565
CP028158.1\|AVT31886.1\|5309219_5310281_-\|dihydroorotate-dehydrogenase-(quinone)	unknown	unknown	gnl\|CDD\|235388
CP028158.1\|AVT31883.1\|5306443_5306761_-\|integration-host-factor	unknown	unknown	gnl\|CDD\|223177
CP028158.1\|AVT31892.1\|5318903_5319338_-\|transcription-antitermination-factor-NusB	unknown	unknown	gnl\|CDD\|273891
CP028158.1\|AVT31897.1\|5322561_5323305_+\|esterase	unknown	unknown	gnl\|CDD\|223669
CP028158.1\|AVT31889.1\|5316025_5316949_-\|aspartate-carbamoyltransferase	unknown	unknown	gnl\|CDD\|234849
CP028158.1\|AVT31885.1\|5307904_5309179_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	unknown	unknown	gnl\|CDD\|273109
CP028158.1\|AVT34726.1\|5314718_5316017_-\|dihydroorotase	unknown	unknown	gnl\|CDD\|236479
CP028158.1\|AVT31896.1\|5321484_5322477_-\|transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
CP028158.1\|AVT31894.1\|5319956_5320400_-\|type-II-3-dehydroquinate-dehydratase	unknown	unknown	gnl\|CDD\|235443
CP028158.1\|AVT31888.1\|5313600_5314719_-\|carbamoyl-phosphate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|237139
CP028158.1\|AVT31899.1\|5325557_5326055_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
CP028158.1\|AVT34727.1\|5324209_5325388_-\|chorismate-synthase	unknown	unknown	gnl\|CDD\|235438

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT31900.1\|5326167_5327475_+\|Bcr/CflA-family-drug-resistance-efflux-transporter	gnl\|CDD\|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.54944e-100
CP028158.1\|AVT31890.1\|5316948_5317530_-\|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR	gnl\|CDD\|235365	PRK05205, PRK05205, bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR.	8.42955e-92
CP028158.1\|AVT31891.1\|5317813_5318302_+\|transcriptional-regulator	gnl\|CDD\|319351	cd16837, BldD_C_like, C-terminal domain of BldD and similar transcription factors. The Streptomyces transcription factor BldD dimerizes via an unusual mechanism that inolves a tetrameric c-di-GMP assembly. BdlD is involved in controlling multicellular differentiation in sporulating actinomycetes.	5.56747e-28
CP028158.1\|AVT31898.1\|5323694_5324210_-\|shikimate-kinase	gnl\|CDD\|234654	PRK00131, aroK, shikimate kinase; Reviewed.	3.6284e-71
CP028158.1\|AVT31893.1\|5319337_5319895_-\|elongation-factor-P	gnl\|CDD\|234788	PRK00529, PRK00529, elongation factor P; Validated.	2.64826e-112
CP028158.1\|AVT31884.1\|5306932_5307775_-\|orotidine-5'-phosphate-decarboxylase	gnl\|CDD\|234651	PRK00125, pyrF, orotidine 5'-phosphate decarboxylase; Reviewed.	1.46473e-118
CP028158.1\|AVT31887.1\|5310277_5313601_-\|carbamoyl-phosphate-synthase-large-subunit	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
CP028158.1\|AVT31895.1\|5320396_5321473_-\|3-dehydroquinate-synthase	gnl\|CDD\|234565	PRK00002, aroB, 3-dehydroquinate synthase; Reviewed.	8.77918e-165
CP028158.1\|AVT31886.1\|5309219_5310281_-\|dihydroorotate-dehydrogenase-(quinone)	gnl\|CDD\|235388	PRK05286, PRK05286, quinone-dependent dihydroorotate dehydrogenase.	3.89304e-173
CP028158.1\|AVT31883.1\|5306443_5306761_-\|integration-host-factor	gnl\|CDD\|223177	COG0099, RpsM, Ribosomal protein S13 [Translation, ribosomal structure and biogenesis].	0.00319712
CP028158.1\|AVT31892.1\|5318903_5319338_-\|transcription-antitermination-factor-NusB	gnl\|CDD\|273891	TIGR01951, nusB, transcription antitermination factor NusB. A transcription antitermination complex active in many bacteria was designated N-utilization substance (Nus) in E. coli because of its interaction with phage lambda protein N. This model represents NusB. Other components are NusA and NusG. NusE is, in fact, ribosomal protein S10. [Transcription, Transcription factors].	1.02481e-46
CP028158.1\|AVT31897.1\|5322561_5323305_+\|esterase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.115e-08
CP028158.1\|AVT31889.1\|5316025_5316949_-\|aspartate-carbamoyltransferase	gnl\|CDD\|234849	PRK00856, pyrB, aspartate carbamoyltransferase catalytic subunit.	0
CP028158.1\|AVT31885.1\|5307904_5309179_-\|adenosylmethionine--8-amino-7-oxononanoate-transaminase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
CP028158.1\|AVT34726.1\|5314718_5316017_-\|dihydroorotase	gnl\|CDD\|236479	PRK09357, pyrC, dihydroorotase; Validated.	0
CP028158.1\|AVT31896.1\|5321484_5322477_-\|transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	5.33747e-60
CP028158.1\|AVT31894.1\|5319956_5320400_-\|type-II-3-dehydroquinate-dehydratase	gnl\|CDD\|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	2.19056e-83
CP028158.1\|AVT31888.1\|5313600_5314719_-\|carbamoyl-phosphate-synthase-small-subunit	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
CP028158.1\|AVT31899.1\|5325557_5326055_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	8.11833e-12
CP028158.1\|AVT34727.1\|5324209_5325388_-\|chorismate-synthase	gnl\|CDD\|235438	PRK05382, PRK05382, chorismate synthase; Validated.	0

>CP028158.1|AVT31891.1|5317813_5318302_+|transcriptional-regulator
MPSEYAKSLGARLRSIRQQQGLSLQGVEEKSNGRWKAVVVGSYERGDRAVTVSRLAELADFYRVPVSELLPDGSGVRHEPTNKIVLDLERLYDEASEDLAYVARYARAIQQQRGDYNGRVLSIRADDLRALAIVYDSSPSGLIERLTEHGVLVADPRALFAS
>CP028158.1|AVT31890.1|5316948_5317530_-|bifunctional-pyr-operon-transcriptional-regulator/uracil-phosphoribosyltransferase-PyrR
MAYPQAAQPQPVPPPSVKVILTSAELARVVDRIAHQILEKTQGAADTVLLGIPTRGAPLARRLAARISAFEDIDVPVGVLDITLYRDDLRRHAVRAIGPTQVPPEGIDGKRVILVDDVLFSGRTVRAALDALTELGRPSSVQLAVLVDRGHRELPIRADYVGKNIPTALAESVKVTLAETDGADEVKLIGGAA
>CP028158.1|AVT31889.1|5316025_5316949_-|aspartate-carbamoyltransferase
MLKHLLSGADLDAATATLILDTAAEMATVAGREVKKLPALRGRTVVNLFYEDSTRTRISFEAAAKRLSADVINFSAKGSSVSKGESLKDTALTLQAMGADAVVIRHPASGAPHRLANWVDGSVLNAGDGTHEHPTQALLDAYTMRSRLGRIAGLSVAVVGDVLHSRVARSNVLLLATLGAKVTLVGPPTLIPVDIGTALAPGTEVSYDLDAVLPTSDVVMMLRVQRERMADSFFPSAREYARRYGLDGPRMARLPDHAIVMHPGPMNRGMEIAPEVADSPRSTIVEQVANGVSVRMAVLYLLLGGMK
>CP028158.1|AVT34726.1|5314718_5316017_-|dihydroorotase
MTAGGDPGAAYLIRGVRVVGAEPTDLLLTGGVVAEAGRGLAARGARVVDGDGLVALPGLVDLHTHLREPGREDAETVESGSRAAALGGYTAVCAMANTSPVADTAGVVEQVWRLGREAGLVDVQPIGAVTVGLAGEHLAELGAMAESAARVRIFSDDGHCVADPRLMRRALEYVKAFDGVIAQHAEEPRLTEGAQMHEGEVSTRLGLTGWPAVAEEAIIARDVLLAEHVGSRLHVCHLSTAGSVEVLRHAKKRGVRVTAEVTPHHLLLTDERATSYDPVFKVNPPLRTAADVTALREALVEGIVDIVATDHAPHALEDKECEWAYARPGMLGLETALSVLLDVLGERWDLIAERMSRTPARIAGLVEHGRDPAPGVPANLTLVDPAARRTIDPGEQASRSRNTPYAGLTLPGRIVATFLRGEPTVLDGKAVR
>CP028158.1|AVT31888.1|5313600_5314719_-|carbamoyl-phosphate-synthase-small-subunit
MSRRRPAILVLEDGRSFRGEAYGSVGETFGEAVFNTGMTGYQETLTDPSYHRQVVVQTAPHIGNTGVNPEDDESGRIWVAGYVVRDPARIGSNWRATGALEDRLATEGVVGIAGVDTRALTRHLRERGAMRVGVSSLTEDPNELLARVREAPRMEGADLSAEVTTPRPYVVQAEGEHRFTVAALDLGIKRNVPRRLAARGVTTHVLPASSSIDDLLATGADAVFFSPGPGDPATADHPAGLAREVMRRQVPLFGICFGSQILGRALGFGTYKLGYGHRGINQPVLDQSTGKVEVTSHNHGFAVDAPLNQVIDTDFGGVEVSHVCLNDNVVEGLRARDVPAFTVQYHPEAAAGPHDADYLFDRFAELIEKKGS
>CP028158.1|AVT31887.1|5310277_5313601_-|carbamoyl-phosphate-synthase-large-subunit
MPRRTDLKHVLVIGSGPIVIGQACEFDYSGTQACRVLRAEGLRVSLVNSNPATIMTDPEFADATYVEPITPEFVELVIAKERPDALLPTLGGQTALNTAVALHESGVLAKYGVELIGADIDAIRRGEDRQLFKEIVAKAGGETPRSRVCHSMDEVRATVGELGLPVVIRPSFTMGGLGSGMAHTDEDLERIAGAGLAASPVHEVLIEESVLGWKEYELELMRDRHDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRLRDLGIAVLREVGVDTGGCNIQFAVNPRDGRLVVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDEIPNDITLKTPAAFEPTLDYVVVKIPRFAFEKFPAADKELTTTMKSVGEAMSLGRNFPEALNKAMRSMETKEGGFWTVPDPAGATCENTLAALGTPHDGRLYTVERALRLGASVAQVSEASGGMDPWFLDQIAGLVELRAEIVAAAVLDEELLRRAKRAGISDRQLAALRPELAAEDGVRTLRHRLGVRPVYKTVDTCAAEFAAGTPYHYSSYEEETEVTASDRPKVLILGSGPNRIGQGIEFDYSCVHAVMALRAVGYETVMVNCNPETVSTDYDTADRLYFEPLTFEDVLEVWHSEDSSGRAAGGPGVVGVVVQLGGQTPLGLAQRLKDAGVPIVGTSPESIHLAEERGAFGALLDRAGLRSPAHGTATSFSEAQAIAAEIGYPVLVRPSYVLGGRGMEIVYDDETLRGYITRATDISPDHPVLVDRFLDDAIEIDVDALCDADGEVYIGGVMEHIEEAGIHSGDSSCALPPITLASSHLAAVRHYTVQIARGIGVRGLLNVQYALKDDTLYVLEANPRASRTVPFVSKATAVPLAKAAARIMLGATIAELRAERLLPPTGDGTTTPVDAPVAVKEAVLPFKRFRTPTGKGIDSLLGPEMKSTGEVMGIDTAFGHAFAKSQAAAYGSLPVRGRVFVSVANRDKRGMIFPVKRLADLGFEIVATTGTGEVLRRHGISCTLIRKHYEEGADSPDAVSLIAAGEVDLVINTPQGSGASARSDGYEIRSAAVGADTPCITTVPGAAAAVMGIEALIRGDMSVRPLQELHAALRAGE
>CP028158.1|AVT31886.1|5309219_5310281_-|dihydroorotate-dehydrogenase-(quinone)
MSATTTEPGRGTAGGGAVFDRIVRPALFRLGGGDAETAHEWTLRRLAGLSRSPAALAALRARYAVSAPRTVFGIGFPNPVGLAAGMDKDGAALPAWPALGFGFVEVGTVTAHPQPGNPRPRLFRLPESAAVINRMGFNNAGAEALAARLAALRRPLGVPLGISLGKSKVTPLDDAVADYLASYRALAPYGDYFAVNVSSPNTPGLRALQDRAHLDALLTALVGEKPILVKIAPDLTEPAIAELLAVCLDRGAAGVIATNTTLGRDGIAAADAHRAGEAGGLSGRPLTARTREVVSFVHRETGGALPVVGVGGILDPADGTALLDAGASLVQLYTGFVYGGPGLVRAVARASRR
>CP028158.1|AVT31885.1|5307904_5309179_-|adenosylmethionine--8-amino-7-oxononanoate-transaminase
MTPEEIVAADRAHVWHPYAPMPASTDPFVVSSAEGVRLRLADGRELVDGMSSWWAAIHGYRHPVLDAAVTDQLGRMSHVMFGGLTHEPAVRLADTLVGITPPGLEHVFLCDSGSVSVEVAVKMALQYQRGRGRPQRHRLATWRGGYHGDTFHPMSVCDPVGGMHSLWTGVLPRQVFAAEPPPGFAAPVDPGYATALADALHRHAGELAAVIVEPVVQGAGGMRFHNPEYLRLLREVCTEHDIVLIFDEIATGFGRTGALFAAEHAGVTPDVMCLGKALTGGYLSLAATLCTPGVAEGISATGVLAHGPTFMGNPLSCAVANASIGLLEAGNWAVDVSRISAGLSAGLAPLRGAAGVADVRVLGAIGVVQLDHDVKMSAATEAAATYGVWLRPFRDLIYTMPPYVTGEDDLALICAAIGAAAQAG
>CP028158.1|AVT31884.1|5306932_5307775_-|orotidine-5'-phosphate-decarboxylase
METFGSRLHRAMAERGPLCVGIDPHPALLSRWGLSDDVDGLARFGETVVEALGDRVAVVKPQSAFFERFGSRGVGVLESIIRQLRGAGALVLLDVKRGDIGSTVAAYADAYLDPSSPMYVDAITASPFLGVGSLAPMFDTARKHGGGVFVLALTSNPEGASVQRAVGADGRTVAQTIIEEISQLNAGAEPLGSFGLVVGATIGETGHDLSGVGGPLLAPGLGAQGGRADDLRTVFGGELSKVLPSYSREVLGAGPEPAALRAAAERALADCRAALTGGGQ
>CP028158.1|AVT31883.1|5306443_5306761_-|integration-host-factor
MPLPQLSPEQRAAALEKAAEIRKARAKLKEELKQGKTNLAAVLDRAESDDVVGKLKVSAVLQAMPGIGKIRATQIMEKLKIADSRRLRGLGEQQRKALLGEFSAN
>CP028158.1|AVT31892.1|5318903_5319338_-|transcription-antitermination-factor-NusB
MAEGPKQQMPARRKARKRALDVLYEADVRTRPVAEVLAGYLQRLEQPRPEHLDYAIGLIEGVAEYQARIDELIDSYAEGWTLDRMPVVDRNLARIAIYELLYVDEIDDAVAISEAVELARQMSTDDSPRFLNGLLGRIAEYATR
>CP028158.1|AVT31893.1|5319337_5319895_-|elongation-factor-P
MATTNDLKNGLVLNLDGELWAVVEFQHVKPGKGGAFVRTTLKNVLSGKVVDKTFNAGTKVDTATVDKRTMQYLYADGEDYVFMDLETYDQIPVPGGTVGEAANYLLPEAEAIVATHEGVPLYVELPTSVVLEITYTEPGLQGDRSTGGNKPATVETGATVQVPLFITTGEKIKVDTRDGRYLGRA
>CP028158.1|AVT31894.1|5319956_5320400_-|type-II-3-dehydroquinate-dehydratase
MRVYVLNGPNLGRLGIRQPEVYGATSYADLVASCEATGRELGLEVRVRQTDAESELLGWLHQAADEEAAVVLNPAAWSHYSYAVRDACAMLRGPLVEVHISNIHAREEFRHHSVVSAVATGVICGLGVDGYRLALLHLAALRDRSNG
>CP028158.1|AVT31895.1|5320396_5321473_-|3-dehydroquinate-synthase
MDELTRIPVGGERPYDVLVGRDLLAALPPLLDGAQRVAVLHAPPLKAQADELAERLRAAGTEPLTVPVPDAEAGKDIEVAAACWARLGAAGFTRTDAVVGVGGGAVTDLAGFVAACWLRGVRWVPVSTSLLGMVDAAVGGKTGVNTAAGKNLVGAFHPPVGVLCDLAMLDSLPAVDLTAGLAEVVKCGFIADPAILELIESDPTAATDPTGQVVRELVERAVRVKAEVVSGDLREAGRREILNYGHTLGHAIEKVEGYRWRHGHAISVGQVYAAGLAWRAGRLDEPTAARHRTVLTTLGLPTSYRADAWPELLAAMRVDKKARGNRLRFVVLDGLAEPGILDGPDDELLRDAYAEVAG
>CP028158.1|AVT31896.1|5321484_5322477_-|transcriptional-regulator
MPHPAARVLGMLELLQGSHRLTGAELAARLGVDERTVRRYADTLVELGIPVTAARGRYGGYRLQPGYRLPPLMLTDDEAVAVLLGLVAAEQLGLGTAAPATGLAEAKIRRVLPEPLADRLDGLTRSLGFSLRRPAASPRPATATLLALGAATRSRHRVTIDYRSWRGEASVRDLDPYGLVFHAGRWYVTGHDHRRDEIRTFRLDRIASVATATGTGTFTVPEGFDPVGHVTRSLAEVPYRWEVEVLLETDLEQARRRVPPSAAELTATADGILLRARAEDLTGMAQLLAGLGWPFTVLRPDELRTAVTGYAGTLAGYAARRPPLAADPIL
>CP028158.1|AVT31897.1|5322561_5323305_+|esterase
MATYVLVPGFWLGAWAWREVTEGLRAAGHRAYPMTLTGLADRAHLAGPDVGLETHTADIVGLVEAEELHDVVLVGHSGGGMPVQQAADRLPDRIARVVYLDSGPLPEGTAQFDTNPPEEQARLRALIGDGHLLPPPEWAPATDPNLAGLDDTALDLLRRRATAEPLRAATDPVTLPHGGTVPAALIACTFPVETVRQMVAQGHPFFAGLVGADLYGLPTGHWPMFSESKRLTELLDRIGRALPTSVE
>CP028158.1|AVT31898.1|5323694_5324210_-|shikimate-kinase
MAPVCVLVGVMGAGKTSTGLLVAKGLGVDFRDTDVDIEATAGKPIPEIFVDDGEEHFRTLERAAVADALASFDGVLALGGGAILAEENRAALAGHRVVYLSVELPDAVKRVGLGAGRPLLAINPRATLKHLLDQRRPLYTEVATWTVVTDGRTPEEVAEEILARLAGDRVG
>CP028158.1|AVT34727.1|5324209_5325388_-|chorismate-synthase
MLRWLTAGESHGPALVAVLEGLPAGVEVTSEEIVRQLGRRRLGYGRGARMAFERDEVEIIGGLRHGLTLGSPVAIRVGNSEWPKWQTVMAADPVDPELLAGQARNAPLTRPRPGHADLAGMQKYGHTDARPILERASARETAARVAVGTVARALLRQALGIEIVSHVVELGSVAAKPGLQPRPEDAERIDADPLRCLDPEASARMVAEVDAAKADADTLGGIVEVLGYGVPPGLGSHVQWDRKLDARLAAALMSIQAIKGVEIGDAWQQARSRGSVAHDEIVPTATGVRRVTDRAGGLEGGITTGEPLRVRAAMKPISSLNRALSTVDVATGEPATAINQRSDVCAVPAAAIVAETMVALVLAEAALEKFGGDSVAEIRRNLAGYLDNLVIH
>CP028158.1|AVT31899.1|5325557_5326055_-|MarR-family-transcriptional-regulator
MTDEATVSAAETLGGAVADLHRVLRRSTSRRTGRTPLPDAQVEVLRLVERCPGVSVKEAAERLHTAANTVSTLVGELAGAGLLERTRDPQNRRIVRLRLTPAAHLRIGDYVAHRRDLLLDALHRLDEPARRDVVRAADHLRHLADLLADQEHAARPPGPPEIASS
>CP028158.1|AVT31900.1|5326167_5327475_+|Bcr/CflA-family-drug-resistance-efflux-transporter
MKSARSAAPPGRAAAVGQLLLLSTLTAVGPLSLDMYLPAFPEMTDDLSATPAQVQYSLTTFLFGLALGQLVTGPLSDRWGRRRPVLVGVVAYTVTSLLCAFAPSAEALAALRLLQGLASGTGVVVARAIVRDLHSGVAAAKYFSRLTLIFGVAPAAAPALGNLVLQFGSWRAVFVVLSAIGLLLLAAVAWRLPETLPPQQRHTGGPAATARVMWGLLTDRVYLGYVLAQGLAFAALFAYISGSSFVIQDVFALSAGWFTLVFAVNAVGMTATGQLNARLLDRYSPRRLLGSGLVAGLLAAGALLGGAATANVPTVLVALFVFVSCLGMVLPNGLALALDRHPRYAGSAAALLGALQFTIAAAVAPLAGIGPDDSAVPMAVSVLGSAALSALVVLTLAREGRTGTGRTGGGATGAREPARTELSRTSAGPARAERR

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Crispr_ID: CP028158_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_10

7048332-7048442

Orphan

Consensus_repeat	Method
GGCACCCGATTAGGCACCCGACCTCGCGGCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_10

>merge|CP028158|10|7048332-7048442|CRISPRCasFinder
GGCACCCGACCAGGCACCCGACTGGGCACCCGATTAGGCACCCGACCTCGCGGCACCCGACCAGGCGCCCGACCTCGCGGCACCCGACCAGGCACCCGATTAGGCGCCCGA

>CP028158|10|10|7048332-7048442|CRISPRCasFinder
GGCACCCGACCAGGCACCCGACTGGGCACCCGA	TTAGGCACCCGACCTCGCGGCACCCGACCAGGCGCCCGACCTCGC
GGCACCCGACCAGGCACCCGATTAGGCGCCCGA

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT33118.1\|7041212_7041647_-\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT33119.1\|7042050_7044723_+\|alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234701
CP028158.1\|AVT33116.1\|7039258_7040254_-\|L-asparaginase	unknown	unknown	gnl\|CDD\|199208
CP028158.1\|AVT33128.1\|7051859_7052198_+\|PadR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224609
CP028158.1\|AVT33115.1\|7038086_7039136_-\|LacI-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380519
CP028158.1\|AVT33117.1\|7040382_7041156_-\|peptidase	unknown	unknown	gnl\|CDD\|223616
CP028158.1\|AVT33124.1\|7048509_7049340_-\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT33130.1\|7053054_7053738_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366444
CP028158.1\|AVT33125.1\|7049418_7049871_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235906
CP028158.1\|AVT33114.1\|7036572_7037904_-\|esterase	unknown	unknown	gnl\|CDD\|273828
CP028158.1\|AVT33129.1\|7052194_7053058_+\|ABC-transporter	unknown	unknown	gnl\|CDD\|224054
CP028158.1\|AVT33132.1\|7056321_7058361_-\|amylo-alpha-1,6-glucosidase	unknown	unknown	gnl\|CDD\|225942
CP028158.1\|AVT33133.1\|7058357_7058822_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376720
CP028158.1\|AVT33131.1\|7053929_7055117_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
CP028158.1\|AVT33120.1\|7044891_7045530_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|213983
CP028158.1\|AVT33127.1\|7050461_7051580_-\|glycosyltransferase	unknown	unknown	gnl\|CDD\|275309
CP028158.1\|AVT33121.1\|7045709_7046882_-\|esterase	unknown	unknown	gnl\|CDD\|365903
CP028158.1\|AVT33122.1\|7046993_7047470_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT33126.1\|7050211_7050409_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224423
CP028158.1\|AVT33113.1\|7035434_7036403_+\|ATP-dependent-DNA-ligase	unknown	unknown	gnl\|CDD\|240131

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT33119.1\|7042050_7044723_+\|alanine--tRNA-ligase	gnl\|CDD\|234701	PRK00252, alaS, alanyl-tRNA synthetase; Reviewed.	0
CP028158.1\|AVT33116.1\|7039258_7040254_-\|L-asparaginase	gnl\|CDD\|199208	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type II L-asparaginases, which tend to be highly specific for asparagine and localized to the periplasm. They are potent antileukemic agents and have been used in the treatment of acute lymphoblastic leukemia (ALL), but not without severe side effects. Tumor cells appear to have a heightened dependence on exogenous L-aspartate, and depleting their surroundings of L-aspartate may starve cancerous ALL cells. Type II L-asparaginase acts as a tetramer, which is actually a dimer of two tightly bound dimers. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase.	1.13263e-96
CP028158.1\|AVT33128.1\|7051859_7052198_+\|PadR-family-transcriptional-regulator	gnl\|CDD\|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	1.55053e-22
CP028158.1\|AVT33115.1\|7038086_7039136_-\|LacI-family-transcriptional-regulator	gnl\|CDD\|380519	cd06296, PBP1_CatR-like, ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group includes the ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation. This group belongs to the LacI-GalR family repressors that are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	3.35919e-112
CP028158.1\|AVT33117.1\|7040382_7041156_-\|peptidase	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	3.77601e-16
CP028158.1\|AVT33130.1\|7053054_7053738_+\|hypothetical-protein	gnl\|CDD\|366444	pfam01061, ABC2_membrane, ABC-2 type transporter.	0.00158553
CP028158.1\|AVT33125.1\|7049418_7049871_-\|hypothetical-protein	gnl\|CDD\|235906	PRK07003, PRK07003, DNA polymerase III subunit gamma/tau.	0.00460118
CP028158.1\|AVT33114.1\|7036572_7037904_-\|esterase	gnl\|CDD\|273828	TIGR01840, poly3-hydroxybutyrate_depolymerase_A_precursor, esterase, PHB depolymerase family. This model describes a subfamily among lipases of the ab-hydrolase family. This subfamily includes bacterial depolymerases for poly(3-hydroxybutyrate) (PHB) and related polyhydroxyalkanoates (PHA), as well as acetyl xylan esterases, feruloyl esterases, and others from fungi. [Fatty acid and phospholipid metabolism, Degradation].	5.13015e-39
CP028158.1\|AVT33129.1\|7052194_7053058_+\|ABC-transporter	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	7.40166e-46
CP028158.1\|AVT33132.1\|7056321_7058361_-\|amylo-alpha-1,6-glucosidase	gnl\|CDD\|225942	COG3408, GDB1, Glycogen debranching enzyme [Carbohydrate transport and metabolism].	1.35757e-76
CP028158.1\|AVT33133.1\|7058357_7058822_-\|hypothetical-protein	gnl\|CDD\|376720	pfam02036, SCP2, SCP-2 sterol transfer family. This domain is involved in binding sterols. It is found in the SCP2 protein, as well as the C-terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pfam01145.	0.000180183
CP028158.1\|AVT33131.1\|7053929_7055117_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.69066e-12
CP028158.1\|AVT33120.1\|7044891_7045530_-\|hypothetical-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	4.53848e-08
CP028158.1\|AVT33127.1\|7050461_7051580_-\|glycosyltransferase	gnl\|CDD\|275309	TIGR04516, probable_glycosyltransferase, glycosyltransferase, activator-dependent family. Many biosynthesis clusters for secondary metabolites feature a glycosyltransferase gene next to a P450 homolog, often with the P450 lacking a critical heme-binding Cys. These P540-derived sequences seem to be allosteric activators of glycosyltransferases such as the member of this family. This model describes a set of related glycosyltransferases, many of which can be recognized as activator-dependent from genomic context.	8.14441e-62
CP028158.1\|AVT33121.1\|7045709_7046882_-\|esterase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.04402e-59
CP028158.1\|AVT33126.1\|7050211_7050409_+\|hypothetical-protein	gnl\|CDD\|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	1.52895e-05
CP028158.1\|AVT33113.1\|7035434_7036403_+\|ATP-dependent-DNA-ligase	gnl\|CDD\|240131	cd04861, LigD_Pol_like, LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-homologous end joining (NHEJ)-mediated repair of DNA double-strand breaks (DSB). NHEJ-mediated DNA DSB repair is error-prone. PaeLigD is monomeric, containing an N-terminal phosphoesterase module, a central polymerase (Pol) domain, and a C-terminal ATP-dependent ligase domain. Mycobacterium tuberculosis (Mt)LigD, also found in this group, is monomeric and contains the same modules but these are arranged differently: an N-terminal Pol domain, a central phosphoesterase module, and a C-terminal ligase domain. It has been suggested that LigD Pol contributes to NHEJ-mediated DNA DSB repair in vivo, by filling in short 5'-overhangs with ribonucleotides; the filled in termini would then be sealed by the associated LigD ligase domain, resulting in short stretches of RNA incorporated into the genomic DNA. The PaeLigD Pol domain in vitro, in a manganese-dependent fashion, catalyzes templated extensions of 5'-overhang duplex DNA, and nontemplated single-nucleotide additions to blunt-end duplex DNA; it preferentially adds single ribonucleotides at blunt DNA ends. PaeLigD Pol adds a correctly paired rNTP to the DNA primer termini more rapidly than it does a correctly paired dNTP; it has higher infidelity as an RNA polymerase than it does as a DNA polymerase, which is in keeping with the mutagenic property of NHEJ-mediated DNA DSB repair. The MtLigD Pol domain similarly is stimulated by manganese, is error-prone, and prefers adding rNTPs to dNTPs in vitro. The MtLigD Pol domain has been shown to prefer DNA gapped substrates containing a 5'-phosphate group at the gap.	2.63267e-77

>CP028158.1|AVT33122.1|7046993_7047470_+|hypothetical-protein
MAEELAPGHANLIGFRLPDGTLSTAATEPAGTVGFRARCSCGWTGAGDYPPADEGRWMAASEWSGHIKPILAATPPGWLLSRSDTLRDNVAELATTWPLQALGILAEVERWQRPLIERAVVAAREAGLSWAEIGNALGISRQSAHERFRNVVPARRAS
>CP028158.1|AVT33121.1|7045709_7046882_-|esterase
MSVVSGTVAAGYEPVREAFLANFETRSELGAAVTVYRYGREVVRLWGGTADPTTDRAWRAETLQVVYSATKSVPAACAHLLAQRGQLDLAAPVAEYWPEFAAAGKGRIPVRWLLSHQAGLPVLDRRVPLAEALAWHPVVEALAAQAPVWEPGTAHGYHGLTYGWLVGEVVRRVSGRSLGRYFADEIGKPLGLDFWIGLPAAETHRVSRLVEQPAPAPAPEEVTERMREILAAYTDPASLTVRSVTVTDPPLDLTDPATWTAEIPAVNGICTASSLARFYAGLIGEVDGIRILDAATLAAATAEQASGVDRVLMVPTRPALGFGLPLPDQPWWSPTAFGFPGHGGSLGYADPASGIAFGYVTNGLRVTLGPDPRTVSLVEALRAVLSRQPD
>CP028158.1|AVT33120.1|7044891_7045530_-|hypothetical-protein
MTTQNDWLTRRTGVLPTAPPTERLSPKSVLDEATRPTAPEPPPEVTFTHQGRYAGRHLVDVHDHYRAELRQVRDILQQVREGTSQVGDARDQLNMMTIRANDWTLGGVCQAQCRAVATHHTMESQGIFPHLRRSQPDLAAVLDRLHDEHLAIHEVLEGVDAALVHLARNPTDYGPISEAIDLLTDTLLSHFAYEEAQLIGPLARHGFYPGQV
>CP028158.1|AVT33119.1|7042050_7044723_+|alanine--tRNA-ligase
MRSSDIRRSFLDYFTERGHTPVPSSPLIPDDPALLLTIAGMNQFKTHFLGESTPPAPRLTSVQKCVRTNDIDNVGRTSRHATFFEMLGNFSFGDYFKAEAIGYAWELLTRHYQLDPDRLWITVFTDDDEAVDLWRRVGVPERRIQRLGMADNYWSMGTPGPSGPSSELCYDRGPAFGPEGGPAVNDERYVELWNLVFMQHRRGAGGVKRDFPILGDLPSRNIDTGLGLDRLATILQDVETVCETDLLAPTLRVVAELAGRPYPGRDGSPESVSFQVVTEHARTAAFLIADGVLPGNEGRGYVLRRIMRRAVRHARTLGIEEPVLGAVTGSVIANLGTAWPELVAQRELVEAVTAHEEETFTGTLRQGGRLLDAAIGRARETSTGRLSGETAFELHDTYGFPIDLTVEAARAAGLDVDRDRYATLLDEQRRRARDGGRDRAAAAPHRIRSYRELLTRHGRTDFVGYTDRQVETEVLAVLRDGRPVESAGEGDRVELVLRRSPFYPESGGQVGDAGRVRTADGGLVQITDTRYGLDGLHVQYGRVASGEVRPGEPVAAQVDGERRAATERSHSATHVLHAMLRRVLGPHARQQGSLVAPGRLRFDFAHFAPVDETALDTIGTLVDDYLLADPEVRVWQASRAEAEAAGATAFFGDRYGEQVRVVDIGDASRELCGGTHVGHGAQAGRVRILGESSVGTGVRRIEALTGRDALRHADTERRLLAEVGRLVGARPEELLDTLGKRLDALGAAEAALRRYRRAELDSIAGTLVAERRAVGSGWLVSARRDDLTPTELRTVASGVLARSPAGTPTVVVLATADDERAQLVAGLDRTLLDRGGRARDLLAEPGRLIGGGAGGTGNLAHAGGRRAERVGQALSRAESAAADLLSRHPG
>CP028158.1|AVT33118.1|7041212_7041647_-|hypothetical-protein
MDRFLETALTVDVTSAAVAAADAAVNEASRQADLLIGGRPAPGSPEWAAEQEGAAGRQREIASQLVHFRIVLASGVDPFGSVVGLRRWGVTWELIARAAGVSRQAAHERWGRRVLETLDPYGTGELGGPVADDEADLRTTDGGS
>CP028158.1|AVT33117.1|7040382_7041156_-|peptidase
MPKINVYLPDELAEAVRVAGIPVSAVCQRALEQAVRRVTAIRETALGDLDDADLATRLPNFTPRARATVLLAVDRSREEGSAAVGTAHLLAGMLAEGTNLALHVLRVEEIEPDRVLQDLAGQPAAEPGGDPDDSLHFSGPAANALQLAVTEATAFGHNYVGCEHLLLGLVAEPDGVGGQLLRSLGAELRLTRRAVAAALAGYVHLRAQTPAEPPSGSAAPSPEVAALLAAAVRRELQPIVARLERLEERAGRTDAVD
>CP028158.1|AVT33116.1|7039258_7040254_-|L-asparaginase
MPGRVLLLATKDTIAYSTGPGREGVASGAELLGTIPPERLAAEVTVEDVLAEPSWDTTPGTMLGLARRARSAILADGFDGVVVSHGTDTLEETAYLTDLLAGPAAVRGTIVFTGAQRQFDELSPDGPRNLASSIAAAADPLLRGVGAVVCVDDELHAARWVGLVDATTVRGFSSTPFGPLGRVVGERVELVGPTPPRPPEAYGEPESEVALLKTYPGMDSGLLGAVVDAGARGVVLEGTGPGNVPAALFAAIAELTDWDVPVVVASRCRTRTVDLAELPPPAGLAARVGAIGARGLPAGKARAALMVALGDGGGVAAARDWFDRLVPPPGR
>CP028158.1|AVT33115.1|7038086_7039136_-|LacI-family-transcriptional-regulator
MTGTNPQAARSGRGRVLTVAKIARLAGVSAPTVSRVINGQTGVALETRKRVEAILREHGYRRPGGSTSVAIVELVFHALESLWALEIIRGVEKVAREHDLAVVLTEMQGRLTPGRAWTEQVLTRRPIGVIAVFSELTVAQQSQLATRSIPLVVLDPTGEPLHQTPSVGATNWNGGLAATRHLLDLGHRRIAMLSGPPEWPCCRARLDGYRAAMDAAGVPVDPDLVRISTLYVEGGLADGRELLALPDPPTAIFTANDLQALGVYEAARRAGVRIPDELSVVGFDDLSFTRWSGPPMTTIRQPLEQMGATAARMIIDLAAGHALDQHRVELATELVVRESTAPPSGRTPA
>CP028158.1|AVT33114.1|7036572_7037904_-|esterase
MRRLVRALAVATSAVLLGAGMVSLTVATPASAAALTEVTNFGTNPSNLRMHLYVPDRLAARPAIVVAVHYCTGTGPAFYSGTQFAALADRYGYIVIYPSATRSGQCFDVYSPQALRRDGGSDPVSIMSMVRYVQQRYSTGQVFATGVSSGGMMTNVLLGNYPDVFTAGAAFAGVPHSCFATTGGSTWNSECANGQIIRTAQQWGDLVRAAYPGYTGARPRMQLWHGTNDETLRYANFGEEIKQWTNVHGLSQTPTYTDTPQSGHTRTRYGGSGPTAPVEAISMQGVPHNLPVNAAEAIRFFGLDSTPSPTATPTPTRTPTAGPTNTPPPTQTPTPPPAGGCAVSYTVNAWSGGLTAAITITNRGTSAINGWTLSFTLPAGQTITSGWNASYSPNSGAVTARNAGYNGTIAPNASVGIGFQASHTGNTGRPASVSLNGTACTLS
>CP028158.1|AVT33113.1|7035434_7036403_+|ATP-dependent-DNA-ligase
MTGRADEVRDGVSLTNLDQPLFDGADATKRDLVDYLDEVRDPLIGQLRDRPLSVIRVLRGQPPFMQKNVPRYTPSWVSTVTLWAEASRREVSYALCNDRRTLLWFGNQRAVEYHPTLVTAQRRDRPTHLVLDLDPPAPETFPLVVSAAHLVRQVLDEAGLSGVVKTSGAKGVHVFVPVDPEAPIEDVAAATRALAARAERLDPALATTAFIREDRGGRVFVDSTRSGGATVVSAYSPRLRPGVPVSFPVPWEELDRVTPADFTLRTVPRLLAGHDPWTERMPQPQRLPADLVAEGHTIPVARVQAMHEGKRRARARRAAEAD
>CP028158.1|AVT33124.1|7048509_7049340_-|hypothetical-protein
MENLLFDFLIEVTRATAVWLVLLGLVLAAGIWLVVRPRAATATATAADQPNDESGYDVAVRDAEGRRERLVARAAELHRYAEEVAVAAERSAVTAQRRRDEWLAAQEAVESTWQAYEEADAAARRLAAAAVLPEPRTPRTPAEYADRERFLHRAAMAACTRQELTVLQLSDALANRNGWDPRRHPAEQEIVLRRAARDSALAAHRAAEERERAAWRDAEVAAAAARSLREEAFAAASRAAALRRWLPSPAGTSVGSASEGVRQPDPARRWRAARAG
>CP028158.1|AVT33125.1|7049418_7049871_-|hypothetical-protein
MRFVTALVLMGLLLGAGGARTGPSGPALAAAGPRPAAAQSTVEDVGAARSDAPDPGPVVRIKQHPAADLPSGVSDEPPVAAAEQPPVLFESAVAADERSAATGSVVPTVLVRADLLGGQPDRPALGAVAGVAPAGDAYARVVGPRAPPLG
>CP028158.1|AVT33126.1|7050211_7050409_+|hypothetical-protein
MPVLLAHGRADAAVPVGQAVALTSALLRAGHPVHSLVTDGGHALPLHRPDIRAVVAAFLDANLPG
>CP028158.1|AVT33127.1|7050461_7051580_-|glycosyltransferase
MRVLFASAPLLGHVFPMVPLAEALRDAGHEVLLATGGDGLAVGRTGLPVEDIAPGFRFDRIARRTMLRHPLTARAELAGRAGTRGVALLFGAANEQMVDGLVTLADRWQPDLVVHEPLAVSGALAAARRAVPAVLHENSLFDGAELVRVTAARLVRAQQRSGIGSLRPSAATLTIAPPSVVGERAGWPLRGVPSTGVGELPEWLRGPGERPRILVSRSTVAGPGGGTLMTSVVRAAAGVDAEFVLVRPDRRVLRHGPLPDNVRTVDWIPINAALPYCAGVVHHGGAGSVLGALAAGVPQLVVPGPGDRRHNAELVAARGAGLAVPERAISGAELGRLVTDPGLRSAADEVRREMAAMPAPAELVPRLEALLG
>CP028158.1|AVT33128.1|7051859_7052198_+|PadR-family-transcriptional-regulator
MDQERRGQWLRGVLDLCVLALLHRRESYGYELAQSLDASGIGPIQGGTLYPVLLRLQRTGLVSAQWREGAAGPARKYYRITPAGAETLRRTAVDWDAFASGVGAVLREVQTR
>CP028158.1|AVT33129.1|7052194_7053058_+|ABC-transporter
MNSDGWLQALTGELHRQGLDADLVRHVVAESATHLRDSGEPPLQVFGPPGTYAAAVAESLGTSRQSAGIGTARVGTPTRAPHGAGPVRLEVRGITKRYRRRPVLTGVDLTVRAGEIAAVVGANGAGKSTFLRICAGLLSPDSGRVRVHGTLGYCPQSGGTADFLYPEEHFVLVGAGRGLQRAQARAAGRAHAAALDWDPAGRTQARHLSGGTRQKLNLVMAALGEPDVLLLDEPYQGFDRGTYLDFWQQLWRWRADGRAIVVVTHLLNQLDRVDTVLDLTPARETSA
>CP028158.1|AVT33130.1|7053054_7053738_+|hypothetical-protein
MTKIWTVAELALREVVRRRGVLLILLVFPLAFYASRRDDHAGQSIRFVCLGLSWALSTAALFAGSAARGIESRLRLSGYRAHHLHLGRLLALWTVGALLSVPYFLLVRFDQDDVRYGAIALIMALTVATAVPFGLALSAILPRELEGTLVLLIVVGLQMVMDPADTAARALPFWFSREIGTYAIDHTDSGYLARGLLHGVILTVALTALVATASGIRLRQRRHLRFE
>CP028158.1|AVT33131.1|7053929_7055117_+|MFS-transporter
MSSTVDTSALAVLKTPQTARVLAASLLGRIPLGAAPLALLVFARETMTLTLAGLLVGAYTAGMAVGQPMLARLADRWRQPPVLWLAVTVSTAGFALVAASLAGPLTVGAAALAGLGAPPFEACLRVLWRDLLPEERIHTAYTLDTATQELIFVVGPVLTLGAVAAFGPAGGLAAAALCQAVGTAWFATAPAVRRWRGVPAVRHWAGPLRSGPLRVVLGALVLIGAGVGSVAVAATGYAEASGGRSWAGWLLAAQAVGALAGGLLYVRSRTARRYGTLPRAAAALALGYLPLLLIPGPPVMLALMAVSGLALPPLLTITFVGIDAVAPAGTAAEAFAWAATAFSVGSALGAAATGPLLDGTGSTAAGFAIAPVTIGLAWLVLALAARRPTPTPAGV
>CP028158.1|AVT33132.1|7056321_7058361_-|amylo-alpha-1,6-glucosidase
MKDLVSILDGNTFMLSDSTGDVDPSPDYPSGLFAWDTRFLSKWVLTIDGERLHALSIDDLQYFESRFFLVPGQPTHYVDAKTSVIRHRSLGGAFEEQLTVLNHRDESVVLTLRMEIDSDFADVFDAREFRSMPGRAMKFVEEGRLRLRHQRDRHVSETIVTSSEPAEIDADGLTFRVELGAHGTWSTTIRATGVIQGAGGRDVRENLRGYQQVRPEKRRELQEWLALAPKLTCDSETLSDTYRRSLIDLAALQYTGLTSQVKLTATGLPWYMTLFGRHSLLAGFQTLPFLPHIARSALWLLALLQGGRIDDFRDEEPGKIMHEIRYGEPGGFEDTPYTTYYGTADCTPLFVILLDEYELWTGDGDTVRLMEYEARSALAWIDTYGDLMGDGYVWYECRSPGGLENQGWKDSWNSVMYADGRLPGKPRATCELQGYAYDAKIRGARLARTFWNDPAYADRLEREAADLRSRFNRDFWIAERGYYALALDAEGGQVDALASNIGHLLWSGIVDESRAGLVANHLLSRPLFSGWGVRTLAYDQAWYNPVGYHTGAVWPSDNSLIAMGLRRYGFVEQAARLAVTMIEASEYFGGRMPEAFAGYDRQLTKYPVQYPRACSPHCSSAGTPLVLLRTLLGLRPHQDHLTIDPAIPERLGRIELIGIPGRWGRTDAFGRGRVQLEPE
>CP028158.1|AVT33133.1|7058357_7058822_-|hypothetical-protein
MARAAVRDAGRVGNGRHQPMADPTAEFFCRVEEHGPEMLPAHARGTLRFDLDRDGHVDHWFVAINRGNVLVSHEKRDADCVVEAEKALFDRCATGEAQVIAAYNRNDVTVRGSLPLLLMFRRVFPSPPGTRDPRERIRERFAGRTGARERERRS

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Crispr_ID: CP028158_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_11

7126626-7126740

Orphan

Consensus_repeat	Method
CGGCGCTCATGTCGGGGACACCAGTCGGGCGAGCCGTCGCCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_11

>merge|CP028158|11|7126626-7126740|CRISPRCasFinder
CGGCGCTCATGTCGGGGACACCAGTCGGGCGAGCCGTCGCCCGCTGACCCGGTGCGGCGGCGGACCCGGCACCGGCGCTCATGTCGGCGACACCAGTCGGGCGAGCCGTCGCCCG

>CP028158|11|11|7126626-7126740|CRISPRCasFinder
CGGCGCTCATGTCGGGGACACCAGTCGGGCGAGCCGTCGCCCG	CTGACCCGGTGCGGCGGCGGACCCGGCAC
CGGCGCTCATGTCGGCGACACCAGTCGGGCGAGCCGTCGCCCG

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT33178.1\|7122894_7124127_-\|xylose-isomerase	unknown	unknown	gnl\|CDD\|366542
CP028158.1\|AVT33190.1\|7137252_7138062_-\|ABC-transporter	unknown	unknown	gnl\|CDD\|130358
CP028158.1\|AVT33180.1\|7124992_7125655_-\|sugar-phosphate-isomerase	unknown	unknown	unknown
CP028158.1\|AVT33189.1\|7136132_7137155_-\|ribonuclease	unknown	unknown	gnl\|CDD\|377085
CP028158.1\|AVT33174.1\|7114898_7117049_-\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|377643
CP028158.1\|AVT33177.1\|7121432_7122902_-\|alkaline-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366747
CP028158.1\|AVT33179.1\|7124126_7124993_-\|hydrolase-TatD	unknown	unknown	gnl\|CDD\|224024
CP028158.1\|AVT33184.1\|7129512_7130721_-\|dehydrogenase	unknown	unknown	gnl\|CDD\|223745
CP028158.1\|AVT33185.1\|7130742_7131825_-\|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380534
CP028158.1\|AVT33173.1\|7113510_7114518_-\|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl\|CDD\|224007
CP028158.1\|AVT33191.1\|7138122_7138935_-\|ABC-transporter	unknown	unknown	gnl\|CDD\|130358
CP028158.1\|AVT33175.1\|7117120_7120012_-\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|271150
CP028158.1\|AVT33186.1\|7131934_7133065_-\|ABC-transporter	unknown	unknown	gnl\|CDD\|224093
CP028158.1\|AVT33187.1\|7133061_7134723_-\|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
CP028158.1\|AVT34956.1\|7108787_7110128_-\|amine-oxidase	unknown	unknown	gnl\|CDD\|366721
CP028158.1\|AVT33188.1\|7134787_7135966_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|224851
CP028158.1\|AVT33183.1\|7127565_7128735_-\|myo-inositol-1-phosphate-synthase	unknown	unknown	gnl\|CDD\|369641
CP028158.1\|AVT33176.1\|7120368_7121436_-\|polyprenyl-synthetase	unknown	unknown	gnl\|CDD\|173833
CP028158.1\|AVT33172.1\|7110142_7112374_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225272
CP028158.1\|AVT33192.1\|7138936_7139881_-\|ABC-transporter	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT33178.1\|7122894_7124127_-\|xylose-isomerase	gnl\|CDD\|366542	pfam01261, AP_endonuc_2, Xylose isomerase-like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.	4.7769e-09
CP028158.1\|AVT33190.1\|7137252_7138062_-\|ABC-transporter	gnl\|CDD\|130358	TIGR01291, Nodulation_protein_J, ABC-2 type transporter, NodJ family. Nearly all members of this subfamily are NodJ which, together with NodI (TIGR01288), acts to export a variety of modified carbohydrate molecules as signals to plant hosts to establish root nodules. The seed alignment includes a highly divergent member from Azorhizobium caulinodans that is, nonetheless, associated with nodulation. This model is designated as subfamily in part because not all sequences derived from the last common ancestral sequence of Rhizobium sp. and Azorhizobium caulinodans NodJ are necessarily nodulation proteins. [Cellular processes, Other, Transport and binding proteins, Other].	1.16883e-23
CP028158.1\|AVT33186.1\|7131934_7133065_-\|ABC-transporter	gnl\|CDD\|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	3.08789e-80
CP028158.1\|AVT33189.1\|7136132_7137155_-\|ribonuclease	gnl\|CDD\|377085	pfam03631, Virul_fac_BrkB, Virulence factor BrkB. This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.	1.16493e-66
CP028158.1\|AVT33174.1\|7114898_7117049_-\|glycosyl-hydrolase	gnl\|CDD\|377643	pfam06283, ThuA, Trehalose utilisation. This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium.	1.04036e-106
CP028158.1\|AVT33177.1\|7121432_7122902_-\|alkaline-phosphatase-family-protein	gnl\|CDD\|366747	pfam01663, Phosphodiest, Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.	2.62327e-65
CP028158.1\|AVT33179.1\|7124126_7124993_-\|hydrolase-TatD	gnl\|CDD\|224024	COG1099, COG1099, Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only].	6.23325e-94
CP028158.1\|AVT33184.1\|7129512_7130721_-\|dehydrogenase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.36475e-69
CP028158.1\|AVT33185.1\|7130742_7131825_-\|sugar-ABC-transporter-substrate-binding-protein	gnl\|CDD\|380534	cd06311, PBP1_ABC_sugar_binding-like, periplasmic sugar-binding domain of uncharacterized ABC-type transport systems. Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems that share homology with a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein superfamily, which consists of two domains connected by a three-stranded hinge. The substrate specificity of this group is not known, but it is predicted to be involved in the transport of sugar-containing molecules and chemotaxis.	4.29667e-81
CP028158.1\|AVT33173.1\|7113510_7114518_-\|sugar-phosphate-isomerase/epimerase	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	3.99442e-34
CP028158.1\|AVT33191.1\|7138122_7138935_-\|ABC-transporter	gnl\|CDD\|130358	TIGR01291, Nodulation_protein_J, ABC-2 type transporter, NodJ family. Nearly all members of this subfamily are NodJ which, together with NodI (TIGR01288), acts to export a variety of modified carbohydrate molecules as signals to plant hosts to establish root nodules. The seed alignment includes a highly divergent member from Azorhizobium caulinodans that is, nonetheless, associated with nodulation. This model is designated as subfamily in part because not all sequences derived from the last common ancestral sequence of Rhizobium sp. and Azorhizobium caulinodans NodJ are necessarily nodulation proteins. [Cellular processes, Other, Transport and binding proteins, Other].	1.2779e-20
CP028158.1\|AVT33175.1\|7117120_7120012_-\|glycosyl-hydrolase	gnl\|CDD\|271150	cd04084, CBM6_xylanase-like, Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains. This family includes carbohydrate binding module 6 (CBM6) domains that are appended mainly to glycoside hydrolase (GH) family domains, including GH3, GH11, and GH43 domains. These CBM6s are non-catalytic carbohydrate binding domains that facilitate the strong binding of the GH catalytic modules with their dedicated, insoluble substrates. Examples of proteins having CMB6s belonging to this family are Microbispora bispora GghA, a 1,4-beta-D-glucan glucohydrolase (GH3); Clostridium thermocellum xylanase U (GH11), and Penicillium purpurogenum ABF3, a bifunctional alpha-L-arabinofuranosidase/xylobiohydrolase (GH43). GH3 comprises enzymes with activities including beta-glucosidase (hydrolyzes beta-galactosidase) and beta-xylosidase (hydrolyzes 1,4-beta-D-xylosidase). GH11 family comprises enzymes with xylanase (endo-1,4-beta-xylanase) activity which catalyze the hydrolysis of beta-1,4 bonds of xylan, the major component of hemicelluloses, to generate xylooligosaccharides and xylose. GH43 includes beta-xylosidases and beta-xylanases, using aryl-glycosides as substrates. CBM6 is an unusual CBM as it represents a chimera of two distinct binding sites with different modes of binding: binding site I within the loop regions and binding site II on the concave face of the beta-sandwich fold.	5.87496e-34
CP028158.1\|AVT33187.1\|7133061_7134723_-\|sugar-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	0
CP028158.1\|AVT34956.1\|7108787_7110128_-\|amine-oxidase	gnl\|CDD\|366721	pfam01593, Amino_oxidase, Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	1.83489e-30
CP028158.1\|AVT33188.1\|7134787_7135966_-\|sugar-kinase	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	3.99393e-56
CP028158.1\|AVT33183.1\|7127565_7128735_-\|myo-inositol-1-phosphate-synthase	gnl\|CDD\|369641	pfam07994, NAD_binding_5, Myo-inositol-1-phosphate synthase. This is a family of myo-inositol-1-phosphate synthases. Inositol-1-phosphate catalyzes the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. Inositol phosphates play an important role in signal transduction.	3.91989e-116
CP028158.1\|AVT33176.1\|7120368_7121436_-\|polyprenyl-synthetase	gnl\|CDD\|173833	cd00685, Trans_IPPS_HT, Trans-Isoprenyl Diphosphate Synthases, head-to-tail. These trans-Isoprenyl Diphosphate Synthases (Trans_IPPS) catalyze head-to-tail (HT) (1'-4) condensation reactions. This CD includes all-trans (E)-isoprenyl diphosphate synthases which synthesize various chain length (C10, C15, C20, C25, C30, C35, C40, C45, and C50) linear isoprenyl diphosphates from precursors, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). They catalyze the successive 1'-4 condensation of the 5-carbon IPP to allylic substrates geranyl-, farnesyl-, or geranylgeranyl-diphosphate. Isoprenoid chain elongation reactions proceed via electrophilic alkylations in which a new carbon-carbon single bond is generated through interaction between a highly reactive electron-deficient allylic carbocation and an electron-rich carbon-carbon double bond. The catalytic site consists of a large central cavity formed by mostly antiparallel alpha helices with two aspartate-rich regions (DDXX(XX)D) located on opposite walls. These residues mediate binding of prenyl phosphates via bridging Mg2+ ions, inducing proposed conformational changes that close the active site to solvent, protecting and stabilizing reactive carbocation intermediates. Farnesyl diphosphate synthases produce the precursors of steroids, cholesterol, sesquiterpenes, farnsylated proteins, heme, and vitamin K12; and geranylgeranyl diphosphate and longer chain synthases produce the precursors of carotenoids, retinoids, diterpenes, geranylgeranylated chlorophylls, ubiquinone, and archaeal ether linked lipids. Isoprenyl diphosphate synthases are widely distributed among archaea, bacteria, and eukareya.	4.38629e-62
CP028158.1\|AVT33172.1\|7110142_7112374_-\|hypothetical-protein	gnl\|CDD\|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	3.81476e-67
CP028158.1\|AVT33192.1\|7138936_7139881_-\|ABC-transporter	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.11534e-104

>CP028158.1|AVT33180.1|7124992_7125655_-|sugar-phosphate-isomerase
MEPEPELERLRAALLAVPDGRPPDPWLAEALRRVGAEPSAIGRLFAAAGRRCGRAPLPDLPHWSADDAARVLLLGALPPAELPGQVEARYREGDAAEKRAVLRALPLLPVGDAGVPLLHDAIRTNDTRLVAAALGPYADRLDQAAWRQAVLKCVFTGIPLAAVHRLDERADAELAGMLAGFADERRAAGREMPADATALLDRLSTLDRSGTPTGPGAEEA
>CP028158.1|AVT33179.1|7124126_7124993_-|hydrolase-TatD
MRIFDPHIHMTSRTTDDYERMAAAGVRALVEPAFWLGQPRTSAASFVDYFDSLVGWEPFRAGQFGIRHHATIALNPKEANDPRCREVLDLLPRYLDKDGVVAVGEVGYDSMTPEEDEVFAAQLALAVEHELPALVHTPHRDKARGTERSLAVVAESGLDPGRVVIDHLNEVTVPLVRDTGCWLGFSIYPETKMSPPRMVELLRKYGTERMLVNSAADWGRSDPLLTRATGEAMLAAGFDDDDVDRVLWRNPVEFYGQSGRLDLEDADESSGAAPPGTFEGNSILRGGS
>CP028158.1|AVT33178.1|7122894_7124127_-|xylose-isomerase
MRLRHADGQLVHLSYCTNVHPAEDLAGVLGQLDTYAVPIRERLGADVLGLGLWLAAPVAAGLAADPQTRRRLRAELAARGLEVVTLNGFPYQSFHAPVVKQAVYHPDWTTRERLVYTLNLATVLVDLLPDDAVRGSVSTLPLAWRQPWERRQADRAARVLDELAAGLTQIAWRTGRAVRVGFEPEPGCVVESTGQAVATLSRVDTDRLGICLDLAHLACAWEDPAQALGRLRAAGLPVVKVQVSAALAAADPVAAADVLRGYVEPRFLHQTRTDACGGAADPADPAHAADDLDAALDANLPGAWRVHYHVPLHAVPAAPLESTVPVLRDALRELFAGPVAGCDHLDVETYTWGVLPAGQRPGSDAELAGGIAAELAFARDELVALGLTEDSASPAGPAAAPVSAPRRHDG
>CP028158.1|AVT33177.1|7121432_7122902_-|alkaline-phosphatase-family-protein
MADPLVVIDVVGLTPRLLAHMPRLRAVADAGCRAELGTVLPAVTCSAQATLLTGALPAEHGIVGNGWYFRELGEVFLWRQHHALMGGEKVWQAARRERPDYTVANVCWWYAMGADVNWTVTPRPIYYADGRKEPDCYTDPPELHDELTGKLGGFPLFTYWGPGAGLPSSRWICRAAEQIMAEKNPDLTLVYVPHLDYDLQRFGPSSPQAAAAASELDGVLGPLLDAAAARNATVVVLSEYGITEASRPVDVNRLLRAEGLLRVYTQDGMEYLDPWTSRAFAVADHQIAHVYVKDPADVPAVAKLCAGLSGVAEVLDAAGKAAHGLDHERAGELVLVAEPDAWFSYYYWLDDARAPDFARLVEIHRKPGYDPAELFFDPAAPGAAKRRAAVALARKKLGMRYLMSVVGLDAGARAVRGSHGRLPADPADGPVLICSDRSAARDRYQATEVKSLLLRLAGVDSAAAGPAGAVPAAAGPAGVDPASAGGGRS
>CP028158.1|AVT33176.1|7120368_7121436_-|polyprenyl-synthetase
MTATVPEVDLGELRKRFDAQLVAFLDRQDPDWPDGAPRGVFTTLHRFVLAGGKRLRPLFCYWGWRAAGGVDGTPIVAAAAALELFHAFALIHDDIMDGSDRRRGEPSVHRLFADLHARSAWRGDPASYGRSTALLCGDLCAAWADQLFHECGLTPEEVHRGYGVFATMRTEVIAGQYLDLVSGVGDGSVASALTVIRMKAARYTVTRPLQIGAALAAGSPELLAALAAFGDPLGDAFQLRDDVLGVFGDPALTGKSILEDLREGKPTVMMALARGSADRAQAQRLKALFGNPELDPEGAAELRAIIVDTGALDRIEQMIKVRVDAALAALADTPLGEETAGVLAALAAETVDRQL
>CP028158.1|AVT33175.1|7117120_7120012_-|glycosyl-hydrolase
MSSTDHPHPPRRPLAGRAPSRRRRWASGAALLLAATTLPAVIAPATPAAAHPINAADFQQVTLARGVAEVGEPMTIAVLPDRSVLHTARNGTLRRTDAAGNTAVLGTLPVYTHDEEGLQGVGVDPGFATNRQIYLYYAPPLSTPAGDAPATGTAAQFAPFAGVNRLSRFTLNADFTLNMGSQVTVLDVPADRGMCCHVGGDIDFDAAGNLYLSTGDDSNPFESAGYAPIDERTNRYPAYDAQRSAGNTNDLRGKILRIRVNANGTYSIPSGNLFAPGTANTRPEIYAMGFRNPFRMSVDKATGHVYVGDYGPDAGSTNANRGPSGQVEFNRVTSPGNYGWPYCTGTNTSTETYNEWTFPDGPSGAKYNCTGGPTNNSFRNTGQSTLPAARPAWIRYAGDAGTPPAFGGGSESPMAGPVYRYNASNPSATKFPQSFDGQFFATEFGRGWIKPIHLNTDGSPGTIDTFPWVGKQVMDSAFGPDGSYYVLDYGTGYFNGDANSALYRFDYVGGGNRAPIAVASGNPTSGVAPLTVNFSSAGSSDPEGGALSYSWAFGDGSTSTAANPTKTYSANGTYTATLTVRDPAGATGTASVTIGVGNTAPTVTITAPAAGQLVAFGDAVPFSITVSDPEDGTIDCSRVKMNYVLGHDSHGHLITTATGCSGTITIPVDGEHDDAANIFPIFDAEYTDRGGLTTHSQHELTPKRRQAEHYETSSGVNKFAKTAAEGGQTVGDINNGDWIAFTPYRLANATSFSARVSSAGAGGTIQLRAGSATGTVLGSATVPVTGGWDTFTTVTGTISNPPAGTTTMYLTFAGSGTGALYDVDAFTVNTGSSGGGGGTGPIVGLAGKCLEIEGGGTADGSQAQIWSCTGSAHQTWTRNGQTLRTLGKCLDVSGAGTANGTKIQLWTCNSTAAQNWAPQADGSLRNAGSAKCLDVSDNSSADGQNVHLWDCIAGAANQKWTLP
>CP028158.1|AVT33174.1|7114898_7117049_-|glycosyl-hydrolase
MRLFRSSTRKTIRPSLAIATTALAVLACTVPAGPASAADAPYDVLVFSKTAGFRHDSIAAGTQAIRELGAANNFTVTATEDAAQFTTANLGQYEVVVFLNTTGDALNASQQSAFESYIRSGRGYVGVHAAADTEYDWPFYGNLVGAYFASHPAIQQANVKAVDRGHAATAHLPQTWTRTDEWYNYRTNARSTARVLATLDESSYSGGGMGADHPHAWCKSYEGGRSFYTGGGHTQASYAEPAFRAHLLGGIRYAAGRSKADCRPESGYSTLYNGSTTGWSQAGPGSFTNADATLTSVGGMGLYWYSAKQFSSYSLKLDWRMAGDDNSGIFIGFPPSSDPWSAVDNGYEIQIDATDAADRTTGAVYTFKSADIAARDAALNPPGEWNSYELLVEGERLRIYLNGVLINDFTNTNPVRSLAGHIGIQNHGTGDDVSFRNIRIKELGGGPGPDPGQNTTVQAEAFTAQSGVQVVGKAGANGGSTIGYLDPGDWAAYNGQNLTGVTSLRARVVSGGAGGTLQVRTGSQTGPVHGTATISNTGGWESYAEVSTALTGLPSGTGNLYLTVAGSGTGLYDVDEFTLVRSTSGGGGSGTGPVVGLAGKCLEIDGGGTADGTQAQINTCVANSARQTWTRTGQTLRALGKCLDISGSGTANGTRIQLWTCNSTGAQNWAAQADGTLRNPGSGKCLDVSNNSSADGQDVHLWDCVAGAANQKWTLP
>CP028158.1|AVT33173.1|7113510_7114518_-|sugar-phosphate-isomerase/epimerase
MARPITLFTGQWADLPFEEVCRLASEWGYDGLEIACWGDHFEVDKALADDSYVDRKRQTLAKYNLKVWTISNHLVGQAVCDHPIDERHQDILPARIWGDGEPEGVRQRAAEEIKDTARAAAKLGVKTVVGFTGSSIWHTLAMFPPVPPSMIEKGYQDFADRWNPILDVFDEVGVRFAHEVHPSEIAYDYWTTRRTLEAIGHRPAFGLNWDPSHFVWQELDPVNFIFDFADRIYHVDCKDAKVRTGDGRRGRLSSHLPWADLRRGWDFVSTGHGDVPWEDSFRALNAIGYDGPISIEWEDAGMDRLVGAPEALQFVRRLAFDAPSAAFDAAFSSKE
>CP028158.1|AVT33172.1|7110142_7112374_-|hypothetical-protein
MAGSRRRAALLLAALLAVGWLAVGALSTPYPGRLSEVATNDNAAFLPEDAEATRGERLAAGFVERPTIPALVVYARDSGVTEADRQRVGADLARFATVPGVVAPLPPPIPSADGKALQVIVPIDNAEDDRTREVVGELRRIAGHGAEPGQVVVVGGPAGMLGDLIEVFSSIDGPLLLVTLGVVFVILLVVYRSPVLWIVPLIAAGLSYALAALAVYFLAKNDVITLNGQAQGILTVLVFGAGTDYALLLIARYREELCRHHDTATAILAAWRGAAPAIFASGGTVIAGLLCLLLSSLSSNQAMGPVAAVGIGATLVVMLTFLPALLLLGGRWAFWPRSPYVAHAATVGRLWKPVAHFVARRSRLVWVVTTLALIALGFGLTQLGATRLSQSELFTNKTDSVLAQEVIDRHYPGGLGSPVTIFPLVGAADRVAAAARTVPGVAEIRAVPAGDPNATGSEAAPGAPGASGAPGTPAGPGPPAGPGPSDGPGASGGPPKVVDGRVQLQATLTAPADSAEAEQTVRELRVAVHGVPDADAVVGGSAAIGVDTADANTRDRNVIIPSVLGVIAVILALLLRALLAPILLILTVVLSFLATLGLCAFLFRYAFGFPGVDASFPLFAFVFLVALGIDYNIFLMSRVREESVHRGTRSGVLRGLVVTGGVITSAGFVLAATFSALAVLPLVILIELGLAVALGVLLDTIVVRSLLVPALTYDIGPAVWWPSKLSRIRGHPDTQPDTQPEAR
>CP028158.1|AVT34956.1|7108787_7110128_-|amine-oxidase
MPAQTDVVIVGGGLAGLAAARRLHRAGTPWLLVEAAERLGGRVGTEAVDGYLIDRGFQVVNTGYPRLSALVDLTSLGLGYFTQGVLVRRGETLHRMVHPLRDPFGAARTVLTGLADAAGLGRLGNVPAGDDVDRVVGGRLADVRRISSVGRATDRLRLAALAARCASLPVDRLLAAPETSTETALRRAGLSDRIVEELLRPFLSGVFGERELHTSSHVFAMIVRSFARGRIGLPAGGIAALPEAVATPLPESLIALGVSATSLRPGLVRTSAGAVRCRAVLVATDPGTATALLPPLRRIRMQSLTTYYHSTAEPPLAEPILLLDGDRRELIANTVVVSHAAPTYAPAGRHLVATSVAGPMVPPEPVVRAELARLYGRPVDDWEHLTTVPVPEALPAAPAPQGRLRKPVALGEGIFVAGDHRASPSVQGALASGWRAAGAINGYLRG
>CP028158.1|AVT33183.1|7127565_7128735_-|myo-inositol-1-phosphate-synthase
MRTGVWLVGGRGSVAVTSTVGALALRAGLAEPTGCVTELPALRSAALPALADLVFGGHDIATTPLVKKAEALAEAGVLPARLVAALAEEFGAVEAELRPAPTGGPQAAAVETIVADLTGFRERHRLDRVVVVNVSSTEPAPQAHPAHASLAELDAALAHGSPLPVSSTYAYAAFTAGCSYVDFTPSTGARLPALAELARRAGLPYAGHDGKTGETLVKSVLAPMFAMRNLRVRSWSGTNLLGGGDGANLAEPAANAAKSASKQRVLGETLGYVPQGNTRIEYVDDIGDFKTAWDLVTFAGFLGTPMRMEFTWHGCDSSLAAPLVLDLARLTAAAHRAGRAGPLTELAFFFKDPLGEVPHALAEQWATLRAFVRELDAEPTSGDPDAVAA
>CP028158.1|AVT33184.1|7129512_7130721_-|dehydrogenase
MSTNEKELRVGMVGYAFMGAAHSQAWRTVNRVFDLPVRARMALICGRDESKVADAAGRLGWEGHTTDWRELIARDDIDIVDVCTPGDSHAEITIAALEAGKHVLCEKPLANTVEEARAMVAAAAKAQTVGVRAMCGFNYRRVPAVSLMRELVASGRLGAIRHVRAVYLQDWITDPQFPLVWRLQKDKAGSGALGDIGAHIIDLTQFVTGQRITGVSAITETFVKERPLPASSSGLAASADGAGAAMGQVTVDDAAVFVARLDGGALATYEATRFATGRRNALRVEINGSLGSVAFDLERLNELEFYDATEPGAEQGFRRILVTEGDHPYMAAWWPPGHIIGYEHSFTHELRDFLAAIATGSDPSPSFTDALQVQLVLDAVARSGELGSSFTAVEQVPAPVSA
>CP028158.1|AVT33185.1|7130742_7131825_-|sugar-ABC-transporter-substrate-binding-protein
MTQHDPLRPVRDLSRRRLLLGGAAVGAGALLTACTSNETGSGGGGNEQVKEADNAANPNSVPGQRVVIGFSAPAADHGWLAAITKNAEAQAKVYSDVEFKTVAAGADAAAQRAALSTLISQKPNVIVMLPHDGKELNASGLEAMKAGIPVVNLDRAFPDALAYRLQIKGDNYGMGVAAGRYIGEQMKAKGIANPIIGEIAGMDELELTKERSAGFAAELAVYGFKVQNRRAARFTADTGQSEASQLLQALPKMDALWNHDDDQGIGVLAAIKQANRSEFIMVGGAGSKAAIDAIAADNSVLKATVTYSPSMASSAISLARLIGQGKGMSDLVELQVPKEITLASETITKENASQYAKLGF
>CP028158.1|AVT33186.1|7131934_7133065_-|ABC-transporter
MTERTETAAPAGTAPPVDRPSPVSPAPAGAPVHKGAGAPGNGTGRWSGDAAETFRRNLGLVGVLVVLIIIGIVTRPDLYGDPSWIRANIFSILTLASVVGVVTVGMTFVIIGGGIDLSVGAIVALAGVWSTTVATQSYGAGGMIFTAIVVAVCVGLVNGFLISYGRLVPFIATLAMLVAARGLAAEISDKQTQVSNNATINGIASTDLLGIPVLVYILAAVVAAGWVLLNRTTFGRRTVAVGGNPEAARLAGINVRRHSMLLYALSGLCCGIAAIMLTAQANSAQAAMANLYELDAIAAAIIGGTLLSGGRGTIIGSLLGVIIFATITNLFAINGLSTEAQNMVKGGIIVAAVLVQQFRFKSVTQLLARNKLTSTN
>CP028158.1|AVT33187.1|7133061_7134723_-|sugar-ABC-transporter-ATP-binding-protein
MTEPDERSGDAERTGADVTDAAGAPHPDGTGPVGDPPPLVTPPADTVPGEVVLRLTDVVKTFPGVRALDGVQLEVRAGEVHCLLGQNGAGKSTLIKVLSGAHQPDSGQVEWLGEPVTFGNPQAAMKAGIATIYQELDLVEDLSVAENAFLGHEPKTLGFVRRGYMARQTREILGRLGHPEIPPRRMVRALPSAGKQIVSMARALSHEARLIIMDEPSAVLAHDEVGNLFRIIRELTAQGIAVIYISHRLEEIREIGDRVTVLKDGRTTAANLPARSTPTRDLVSRMTGRTIEYVFPDRPAETPAAETLLEVRDLGREGEFADVSLTVRAGEIVGIAGLVGSGRSELLETIFGARRPSSGTVSMAGRPVRPGSVGAAVRAGMGMAPEERKSQALLLGEPIYRNVTLATFTRWARLGFTDAGRERAEANEVADRLELRPRDVRRPVRTLSGGNQQKVVVGRWLLGDTKLLLLDEPTRGVDVGARAELYQVIRALAARGVGVLLVSSEVPEVLGLADRVLVMREGRVVHEAPAGELDEDTVLDLVMAGSLMEGAPA
>CP028158.1|AVT33188.1|7134787_7135966_-|sugar-kinase
MRTPEALHLRLLRLLRDQGAVSRAELADRLQIPRPRLLAELERLVGLGYVAEAGLAASRGGRRSTLVELSPDLRFAAVDLGASSIDVEVVNGRLEPVAAYAETTDIRSGPKVILQRVHELLHKARVDGAYERLHAVGIGVPGPVSFRDGVPVSPPIMPGWDRFPVRELLTREHGCPAVVDNDVNIMAIGERHGGVAHSVDDFLFVKIGTGIGCGIYLSGEVYRGTDGCAGDIGHIQVDSHGPMCSCGNVGCLEALFSGAALAKEATVAARSGTSPALAERLAATGTVTALDVAEGAIEGDVTCIRLIRDGGRRVGGVLAGLVSFANPSMIVIGGGLAQLGHILLAEIRSVVYRRSLPLATGNLPVVLSELGPRAGVTGAAVLATDVAFAEAS
>CP028158.1|AVT33189.1|7136132_7137155_-|ribonuclease
MTGSPVRRWSHRPGRRRSRESGMAEERRTGSPGRLPRAAWGTVLRRTLREAQEDNVTDWAAALTYYGVLSLFPALLVLVAVLGLLGDAAVRGVQDVIRDVVPAASARDILLTAITQVQGSTGTAGLVAVLGILGAFWTASGYIGAFSRAANAIYDVPEGRPLARTLLLRIGLTALIGLLVLISLVLLVFSGRLSAQVGRRLGVGEAGVTAWDIGKWPVLVLLVSLIFAVLYWAAPNARQRFRWISPGSVFAVLAWAVVSAGFALYVSYFASYNRTYGSLAGVIVFLVWLWLSNVAILLGAELSAELERERTIRLGGSAEREPYVSLRDDRKLRKRRGRGE
>CP028158.1|AVT33190.1|7137252_7138062_-|ABC-transporter
MVSIVLPRLISFEGAPRRAASVAERNVAALKSAYWVVLISGFFEPLLYLLSIGVGVGALVGDLTLPSGTVVTYAAFVAPAMLAASAMSGALAETTFNFFGKMKYMKLYDGILATPVQPFEIALGELGWAMLRGSLYSAAFLAVMVGLDLTSGIRALVAFPAAVLVGFAFGALGMALSTFMRSWQDFDLMGSAQFALFLFSGTFVPAEAYPSVLRWVVEATPLYRAVHLVRGITVQGGGWGELGDVLYLVGVTALGLVVAGRRMGRLLCK
>CP028158.1|AVT33191.1|7138122_7138935_-|ABC-transporter
MALLEATAATRPRAGLVGRFPALAVLEYNLVAYRRTWRAGVFSSFLLPLLTMVGFGVGVGAYVEAPVAGVPYLDFLVPGLIASTALQVAIGESTWPVLGNFEWIKIYFAQAATPLRVADILGGQLGFVLFRVLTSSLAFLLVAAAFGALHSPWALATLPLVALIGAAVAAPVFAYSSSVRSDSYLALLFRFAVIPMTLFAGVFFPVESLPVVLRWLAYASPLWHGVDLCRAATLGVAPAWSIPGHLLYLGAWVAVGWWLAHAAFRRRLVV
>CP028158.1|AVT33192.1|7138936_7139881_-|ABC-transporter
MVEPVAKDGILIQARGLVKRFGDFTAVDGIDVDVRAGEAFGFLGPNGAGKSSTMRMVGCVSPPTGGELRIMGMDPRRDGPAIRSRLGVCPQLDNLDPELTVRENLTTYARYFGIPRRVARERAAELLDFVQLAERAGSKVEPLSGGMKRRLTIARALVNEPDIVLLDEPTTGLDPQARHLVWERLFRLKQQGVTLVLTTHYMDEAEQLCDRLVVMDGGRIVAEGSPRALIDRYSTREVVELRFAGETQEAFAGKLDGLAERVEVLPDRILLYVTDGDAAVAEVHARALTPASVLVRRSSLEDVFLHLTGRTLVD

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Crispr_ID: CP028158_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_12

7223634-7223734

Orphan

Consensus_repeat	Method
GGTCAGGTGTTCTTCGGCACGGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_12

>merge|CP028158|12|7223634-7223734|CRISPRCasFinder
GGTCAGGTGTTCTTCGGCACGGCCAGCCCATGTCTTCGGGTCAGGTGTTCCTCGGCACGGCCAGCCCATGCCTTCCGGTCAGGTGTTCCTCGGCACGGCCA

>CP028158|12|12|7223634-7223734|CRISPRCasFinder
GGTCAGGTGTTCTTCGGCACGGCCA	GCCCATGTCTTCGGGTCAGGTGTTCCTCGGCACGGCCAGCCCATGCCTTCC
GGTCAGGTGTTCCTCGGCACGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT34967.1\|7225815_7228263_-\|competence-protein-ComEC	unknown	unknown	gnl\|CDD\|377126
CP028158.1\|AVT33262.1\|7233067_7233664_-\|nicotinic-acid-mononucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
CP028158.1\|AVT33250.1\|7215366_7216227_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT34968.1\|7228535_7229357_-\|competence-protein-ComEA	unknown	unknown	gnl\|CDD\|224472
CP028158.1\|AVT33251.1\|7216529_7217432_+\|phytanoyl-CoA-dioxygenase	unknown	unknown	gnl\|CDD\|368580
CP028158.1\|AVT33261.1\|7231940_7232573_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
CP028158.1\|AVT34969.1\|7232569_7232968_-\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|376779
CP028158.1\|AVT33257.1\|7223273_7223540_+\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|376586
CP028158.1\|AVT33254.1\|7219358_7219910_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240037
CP028158.1\|AVT33263.1\|7233758_7236281_-\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|274121
CP028158.1\|AVT33248.1\|7213251_7214475_-\|coproporphyrinogen-III-oxidase	unknown	unknown	gnl\|CDD\|180172
CP028158.1\|AVT33255.1\|7219906_7221787_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
CP028158.1\|AVT34970.1\|7236351_7236570_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
CP028158.1\|AVT33260.1\|7231005_7231851_-\|fatty-acid-binding-protein-DegV	unknown	unknown	gnl\|CDD\|273257
CP028158.1\|AVT33252.1\|7217809_7218571_-\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT33256.1\|7222133_7223117_+\|aminoglycoside-phosphotransferase	unknown	unknown	gnl\|CDD\|270703
CP028158.1\|AVT33249.1\|7214492_7215278_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|236109
CP028158.1\|AVT33259.1\|7229519_7230731_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377511
CP028158.1\|AVT33258.1\|7224595_7225570_-\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|236130
CP028158.1\|AVT33253.1\|7218993_7219281_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT34967.1\|7225815_7228263_-\|competence-protein-ComEC	gnl\|CDD\|377126	pfam03772, Competence, Competence protein. Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.	6.33771e-52
CP028158.1\|AVT33262.1\|7233067_7233664_-\|nicotinic-acid-mononucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	5.14559e-102
CP028158.1\|AVT34968.1\|7228535_7229357_-\|competence-protein-ComEA	gnl\|CDD\|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	6.16958e-31
CP028158.1\|AVT33251.1\|7216529_7217432_+\|phytanoyl-CoA-dioxygenase	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	4.22211e-14
CP028158.1\|AVT33261.1\|7231940_7232573_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.91369e-59
CP028158.1\|AVT34969.1\|7232569_7232968_-\|ribosome-silencing-factor	gnl\|CDD\|376779	pfam02410, RsfS, Ribosomal silencing factor during starvation. This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.	4.89997e-40
CP028158.1\|AVT33257.1\|7223273_7223540_+\|30S-ribosomal-protein-S20	gnl\|CDD\|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	1.83245e-27
CP028158.1\|AVT33263.1\|7233758_7236281_-\|aminopeptidase-N	gnl\|CDD\|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
CP028158.1\|AVT33248.1\|7213251_7214475_-\|coproporphyrinogen-III-oxidase	gnl\|CDD\|180172	PRK05628, PRK05628, coproporphyrinogen III oxidase; Validated.	0
CP028158.1\|AVT33255.1\|7219906_7221787_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
CP028158.1\|AVT34970.1\|7236351_7236570_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.82752e-14
CP028158.1\|AVT33260.1\|7231005_7231851_-\|fatty-acid-binding-protein-DegV	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	5.98048e-93
CP028158.1\|AVT33254.1\|7219358_7219910_-\|hypothetical-protein	gnl\|CDD\|240037	cd04681, Nudix_Hydrolase_22, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.59414e-17
CP028158.1\|AVT33256.1\|7222133_7223117_+\|aminoglycoside-phosphotransferase	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	3.31601e-10
CP028158.1\|AVT33249.1\|7214492_7215278_+\|enoyl-CoA-hydratase	gnl\|CDD\|236109	PRK07827, PRK07827, enoyl-CoA hydratase family protein.	2.39875e-83
CP028158.1\|AVT33259.1\|7229519_7230731_-\|hypothetical-protein	gnl\|CDD\|377511	pfam05426, Alginate_lyase, Alginate lyase. This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyze the depolymerization of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end. This family adopts an all alpha fold.	2.96612e-10
CP028158.1\|AVT33258.1\|7224595_7225570_-\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|236130	PRK07914, PRK07914, hypothetical protein; Reviewed.	6.38969e-98

>CP028158.1|AVT33257.1|7223273_7223540_+|30S-ribosomal-protein-S20
MANIKSQIKRNRQNEKRRLRNKSVKSSLKTAIRKFHEATESGDSAKATELMRDASRKLDKAVSKGVIHQNQAANRKSAIAKRLQSLSA
>CP028158.1|AVT33256.1|7222133_7223117_+|aminoglycoside-phosphotransferase
MAAISVPPRPYDATAVRPGWADLPADLRAAITARLGARVGWAGTAGGGFTRGFAGVLQTVAGDRVFVKAASLVDQRHLSDWYAREAAITAVLPAGLAVARPRWTLTAAGYHVICLDAIDGRMPGLPWAPAELAATLDAYATAAAALRQPPVELAALGVPRLADLARADLAWWTELAAGRETLPEIPAVAGHRLPELAALEARLPGYADRPSMIHGDLRVDNVLLDRAGVAWLCDWTWLCYGPPWFDLASLLVTAYASGLDADALFATHPAGLDAPADGLDAALAALSGYWLVRAAAGSGTGSPHIRAHQRWSAQTALDWLAERQGWR
>CP028158.1|AVT33255.1|7219906_7221787_-|elongation-factor-4
MPPTPDSGANSPGATDPGRIRNFCIIAHIDHGKSTLADRMLQLTGVVDPRQMRAQYLDRMDIERERGITIKSQAVRMPWTVREGDQQGEEAVLNMIDTPGHVDFTYEVSRSLAACEGAILLVDAAQGIEAQTLANLYLALENDLHIIPVLNKIDLPAAQPDKYAEELAHLIGGDPSDCIRVSGKTGEGVPYLLDEIVRQFKPPVGDAKAPARAMIFDSVYDVYRGVVTYVRVIDGRIEARDKIKMMSTGAVHELLELGVISPEMQKAGALGVGEVGYLITGVKDVRQSRVGDTVTINARPASEALGGYKDPKPMVYSGLYPIDGSDYPALRDALDKLKLNDAALSYEPETSAALGFGFRCGFLGLLHLEIIGERLEREFNLDLISTAPNVVYRVGLEDGKEVTVTNPSEYPTGKVAEVYEPVVRATVLTPNDYVGAVMELCQGRRGSLQGMDYLSADRVELRYTLPLAEIIFDFFDQLKSRTKGYASLDYEPTDEQRSDLVKVDILLNGEPVDAFSAIVHKDKAYNYGVNIAAKLQKLIPRQQFEVPIQAAIGNRVIARETIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGRVEVPQEAFIAALSTSDSGDGKGGGKK
>CP028158.1|AVT33254.1|7219358_7219910_-|hypothetical-protein
MIPRGYGPGASFCPRCAAALPGPAPTTCTRCGYQLFVNARPTVGLVILDRPSSGSAAPAVAEPRFLALRRAAEPMIGRWETPGGFCDGWEHPAEAAVREAREELGVSITLGDHLGMYVGSYEFQDEILPVLDNFFLATLDDPRVVLDPAESAELSWFSLVDPPPLAFGTMDVAVREAARRLGA
>CP028158.1|AVT33253.1|7218993_7219281_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MELTVWGIITALIVGLVIGALGRLVVPGRQDIPIWLTMLIGVGAALLGTVIARAAGIATETAGIDWMELLIQVALAAIGVALVAGVGRRRRVSRY
>CP028158.1|AVT33252.1|7217809_7218571_-|hypothetical-protein
MYLEAYTPLVEEWFSALRVSSGLRELRQDGPGRDLVENLQRLDQLFRDLVDGMFAHPTPVLERAVAVVAAHREAVVWEDQLVPSPGAGAEELAASLRHKFKRNISLALLEALICLESALSYGRDTLGLSGETLERTLRGSTSMLASLSVLHDQQEMARMRQLTGDPTEIQHPRFTVADIVRGAFRIGPDKFRAVGPEGQQRIRFGSVPPHGVEVTSPTMKCPAHRLTNEEGQPLNNELWALLVDVYRMSGRLA
>CP028158.1|AVT33251.1|7216529_7217432_+|phytanoyl-CoA-dioxygenase
MFDYGGRTGYEPISDTDRKEFHEQGFLLLRNVLTEDHRAALEAAVDRVYAEEKAKGNTTKDGTLHLLGFLERDELFGELLTHPISFPYMWGLAGWNIYTHHNHLDVTPPALEPEKPYWGWHQDGYRQNSDPETMDPNLPRPMFSLKVAYVLSDLSEKGRGATKVIPGSHLWNSLPRPADLTVQNPDPEGTVEITANPGDAFIFDRRQWHSRSTNLSNITRKMLFVGYTYRWIRPLDELHPDKNGQWYQNRTPVQRQLLGEGTHTANYWGINWNGYVDDEIPLRKELKERGLLDRSIPWLR
>CP028158.1|AVT33250.1|7215366_7216227_+|hypothetical-protein
MAVRTRAVVAAGVALAAVAGFGVYLGAREFGHKLPLPSAAPGCVVEADGRVTLNAEQMANAATIAAVGIRRKMPERAVVVALATAFQESRLRNLAGGDRDSVGLFQQRPSQGWGTPEQIRDPRYAATRFYNALKRVRGWEQMEVTVAAQRVQRSAFPNAYQQWADESEVLTRALLGNATGAVACTVGREPAMRGNAAAVALAAGLKLDWGRLETSVPPELTGLAVPTTDPQVGWRYAHWLVSHADDHGVKTVRFGDLQWTADGGTWAPVKGVPPTPHQVVAEVFTD
>CP028158.1|AVT33249.1|7214492_7215278_+|enoyl-CoA-hydratase
MTSAPDPLVRVSTTHGVTTLTLDSPRNRNALSSALLGQLLDALGAAAADDDVRVVVLSHTGPVFSSGADLKETAAAYREGTVPVAMLGDVLAAIWECPKPVVARIGGPARAGGLGLIAAADVAICAQEATFAFTEVRLGVIPAVISATVLPRLQPRAAAELYLTGDTFDGRRAAEIGLVTTVTSAEALDETVASYCLALVRGAPGALAGAKELLRRGSTESFRAELARLRDLSVRYFHSEEGREGVAAFGEKRPARWVPGS
>CP028158.1|AVT33248.1|7213251_7214475_-|coproporphyrinogen-III-oxidase
MPGVLPAGEPVPVDGALPAAALATVGDRGFGVYVHVPFCASRCGYCDFNTYTATELGGSAGRDGYADQVLAELRLADRVLADRPPTRVDTVFVGGGTPTLLPPDDLARILDGIDRTWGLAADAEVSTEANPESVTRESLKALRAAGYTRISLGMQSAAQPVLAILDRRHTAGRATEAAQEAREVGFDHVNLDLIYGTPGERAEDFAASLRAVLAAGVDHVSAYALIVEDGTRLAARMRRGELAYPDDDVAADRYLAAEAALSAAGFSWYEVSNWARTPAAACRHNLLYWTGGDWWGLGPGAHSHVGGVRWWNVKHPSSYAARLAAGHSPGQAREVLSAEERRTEEVLLGLRLAAGLPLSVLDDAGRAAAAGACRTGLLDGAAYDAGRAVLTLRGRLLADAVVRDLLP
>CP028158.1|AVT33258.1|7224595_7225570_-|DNA-polymerase-III-subunit-delta
MTPASLAPVVLVLGDEELLATRAVAGVVDAARAADPDVDVHDHEAGALGPGEIAELLGPSLFGGRRVLIVRAGQDARKDLAAALLAYAKNPDPEVQLVVAHAGGAKGKAFADGLRAAGAEVVPAAKLKSHRDRVAFVRDEIRRGGGRCTDDAAEALIAAVGNDLRELASACSQLLADTDGRIGVDTVARYYRGRAEVSGFTVADAAMAGDVPGALEALRWALHVGVDPVPIADAIADGVRTVARVSSAGRGSAYQLASSLGMPPWKIEKAQRVGRGWTPEGLADAMYAAAECNAAVKGGSDDRGYALERAVVAVAAARRASASR
>CP028158.1|AVT34967.1|7225815_7228263_-|competence-protein-ComEC
MRASTASPPGPTAGPPDAGHDAAEAAEPPRRPPDLRLAGLAVGAWLSALAGLLIGTGPAVLVAVLAGGAALVLACRSTRRLPAVPGRHGWVVVTVLLGVVCGSVATAARSGVRDAPSIARLAEERARVSAELVVREDPRPIGGVAGRPATYLLSTRLVWAAGEAGNDRVSASVRILVLASDPDWRGLLPGQRVTTTGRLAPPRGGDLTAAVLTVSTPPVLRGTPSWAQRAAGTLRAGLQRACAPLPTEPGGLLPGLVVGDTSRLEPAVEEDFLTTGMTHLTAVSGSNVAIVVGLVLLLARWGRAGPWLAAVLCGTALVGFVILARPSPSVVRAGTMGAIGLLALAVGRPRAALPALASAVTVLVLVDPELAGDPGFALSVLATGGLLLLAPRWRDALRQRGVPAGAAEALAIPAAAQLACAPVVAGLSGTISLVAVPANLLAVPAVAPATVLGVTAAVLSPFWPAGAEGVAWLGSWPAWWLVLVARYGARLPAGTLPWLDGVPGGLLLGALTVALLVAARRPPVRRLVAVVAAAVLVGALPVRLIATGWPPTGWVVVACAVGQGDSLVLPVGVGRAVVVDAGPDPGAVDRCLRRLGVREVSLLVVSHFHADHVQGVDGVFRGRRVAAVVVPQWLEPVEGRGTVERAASANGVPVGAAGAGWTYAAGPVTLTLLGPPHPIRGTRSDPNNNSLVLRAEVHGVSILLTGDAETEEQQALLEVVPVARLRADVLKLAHHGSAYQEPAFLDAVRPAVALVPVGADNGYGHPNAGVLARLSRAGARVLRTDEQGDLAVVEPGSGRLSVAVRGLDPGDPSTR
>CP028158.1|AVT34968.1|7228535_7229357_-|competence-protein-ComEA
MSDDDETVVRQRLSRLLGDRAIPAERSAAGPAPAGTGPDPSADPPAEPGRLAGPGAFDPAGPGAFDPGRRGVKALAVVAVVVVLGAAGWAWLSRPRTEPVAPPPASAATFAPASSTSGAAVGAAEVVVAVAGKVRRPGLVRLPAGARVADALESAGGALPGVDVALLNLARKVTDGELILVGVTPPPGAGPAGAGPPGAPGGATGAQPGGGKVNLNTATVAQLDTLPGVGPVLAQRIVAHREEHGGFRSVADLRQVTGIGDARYEDLKDLVTV
>CP028158.1|AVT33259.1|7229519_7230731_-|hypothetical-protein
MIAAGVLLSTAVIVPYAGPGAAAPAAQAAPPGAEVRIAAPPTFTHPGVLVSRPQLDFVRGRVNAGAQPWKGAYDQMMASAFASLSRTPKPRAVVECGSYSNPNNGCTDERQDALAAYSLALAWYITQDSRYAEKAIQIMDAWSATIRDHTNSNAPLQTAWAGSSWPRAAEIIRYTYGGWSSAGISRFGAMLRDVYLPEIINGNATSNGNWELSMMEASLGIAVFLEDRAVYDRAVGKFRDRLPAFLYLSSDGAYPRGPAGSSIDTRAEIVSYWHDQEVFSDGLSQETCRDFTHTGYGISAISHVAETLRHQGQDIYPEIQDRLRHALGFHARYELGDAVPSTLCGGSLTLGLGPVTEVAFNALNNRRGIPMTRTQQLTERQRPAGTNYLFVAWETLTHAGNPN
>CP028158.1|AVT33260.1|7231005_7231851_-|fatty-acid-binding-protein-DegV
MPVAVVTDSTAYLPAELADRHRLTVVPLIVVLDGTPGREGVDVGPADAAQALAARRFAMSTSRPAPEEFVETYRRLLAEGADGVVSVHLSAELSGTVEAARLAAAELGPRVSVVDARSTGMGLGFPALAAASAAARGAGLTEVRRAALDAIDRTSTFFYVDTLEFLRRGGRINAAEALLGTALSVKPILHMADGGIALRDRVRTAGRGLARLVDLAVEAAGSGEVEVALHHLAVPGRAAELAEKLGGRLGDRLRASYVTEAGAVIATHTGPGLVCVVVHRL
>CP028158.1|AVT33261.1|7231940_7232573_-|histidine-phosphatase-family-protein
MTRLIVWRHGNTDWNAANRVQGQLDVPLNDLGREQATEAAPLLAGLRPDAIVASDLRRAADTAAALAALTGLPIRTDPRLRERFYGQWQGLLMTEVAQRFPAEHARWRSGDPDPGAEVESLDDLGKRVGTALQEAADAVPGGTVVIATHGGGARQGCGYLLGWDSTVLRSVGSLNNCHWTELRHDEVRGWQLRGHNVGRLVAPGPAPAPV
>CP028158.1|AVT34969.1|7232569_7232968_-|ribosome-silencing-factor
MTASDRARELATAAAQAAADKKAQDIVIIDVADQLVITDAFLLASAPNERQVTAIVDAIEEALLALPEKAKPVRREGERAGRWVLLDYVDLVVHVQHSEEREFYALDRLWKDCPTIPFVDRDLVEAEAGIAE
>CP028158.1|AVT33262.1|7233067_7233664_-|nicotinic-acid-mononucleotide-adenylyltransferase
MEADIRRIGIMGGTFDPIHHGHLVAASEVADRFELDEVVFVPTGQPWQKADEPVSSAEDRYLMTVIATASNPRFQVSRADIDRGGPTYTVDTLRDLHSEYGPKVQLFFITGADALEKILSWKDLDQMFELAHFIGVTRPGFVLSDAHLPADTVSLVEVPAMAISSTDCRARVAAGGPLWYLVPDGVVQYIAKRRLYRG
>CP028158.1|AVT33263.1|7233758_7236281_-|aminopeptidase-N
MPSLTRVAAAERAALLTVESYDIELDLTGSAERFRSTTTVRFRAATPGAGTFVEVRPARLLGVRLNGAALDPAALDDNQYPLTGLAAENTLVVEAEMAYSNSGEGLHRFVDPADGETYLYAMSGMDNAQRIFACFDQPDLKAPVTLAVVAPEEWIVAGNGRLDSGPVAGRWVFAPTPPLATYLVSLVAGPYAVRRAEHDGIPLGLYCRRSLTEHLDRDAEEILTVTRQCLDRLHRLFGVRYPFGKYDQAFVPEFNMGAMENPGLVTFRDEFLPRSAVTDAEREQRANSIAHEMSHMWFGDLVTLRWWDDLWLNESFAEYFGTRITAEATRFDRAWTTFALRRKAWGYAADQRPSTHPVAPTEVADATEALANLDGISYAKGASVLRQLVAWLGDDAFLAGLRGYFAAHRFGNATLADLLAALAAGSGRDLAGWAAVWLRQPQLNTLRTEVRLRDDGHYAEVALVQTAPPEHPVLRPHRIGVGLYDPDPAGGGTALRLRDRVEVDLDPAADGGRTVLPGLTGQPAARLLLPNDGDLTFAKVRLDAASVAAVPAALPELADPLTRALLWAEALDAVTDGERPVADLVALVVAALPAETEVVVVQDVLARTCDLLDRHLQPEVRPAALEQLAGACARLLAVAPPGGSGQLAAARGWISSTVEVARLTGWLAGKEVPDGLAVDAELRWAVLGRLAVLGAVGEPEVAAEQAEDGSASGAERAATCRAALPDPAAKEHAWRLLVGETSLSNRLLEATARGFWQPEQAELTDSYVERYFAEMPAAARRRTPWVADRVAALAYPRYAVSARTRELAAALLGRDDLPSGLRRVVVDEDDDLRRALAARR
>CP028158.1|AVT34970.1|7236351_7236570_+|DUF397-domain-containing-protein
MAQHPKGDFDLSRAVWQRAEGDDSEGAVEIAFVDDLIGMRNSAEPDGPVLVFTQAEWDAFVAGAQDGEFDLD

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Crispr_ID: CP028158_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_13

7230906-7230981

Orphan

Consensus_repeat	Method
CCAACAAGGCCGACAACACCAGCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_13

>merge|CP028158|13|7230906-7230981|CRISPRCasFinder
CCAACAAGGCCGACAACACCAGCAACGCGAACAACCCGGCGCGGCCAGCAACGCCACAAGGCCGACAACACCAGCA

>CP028158|13|13|7230906-7230981|CRISPRCasFinder
CCAACAAGGCCGACAACACCAGCA	ACGCGAACAACCCGGCGCGGCCAGCAAC
GCCACAAGGCCGACAACACCAGCA

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT34967.1\|7225815_7228263_-\|competence-protein-ComEC	unknown	unknown	gnl\|CDD\|377126
CP028158.1\|AVT33262.1\|7233067_7233664_-\|nicotinic-acid-mononucleotide-adenylyltransferase	unknown	unknown	gnl\|CDD\|234611
CP028158.1\|AVT34972.1\|7240944_7241442_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379228
CP028158.1\|AVT34968.1\|7228535_7229357_-\|competence-protein-ComEA	unknown	unknown	gnl\|CDD\|224472
CP028158.1\|AVT33254.1\|7219358_7219910_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240037
CP028158.1\|AVT33261.1\|7231940_7232573_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
CP028158.1\|AVT34969.1\|7232569_7232968_-\|ribosome-silencing-factor	unknown	unknown	gnl\|CDD\|376779
CP028158.1\|AVT33257.1\|7223273_7223540_+\|30S-ribosomal-protein-S20	unknown	unknown	gnl\|CDD\|376586
CP028158.1\|AVT33263.1\|7233758_7236281_-\|aminopeptidase-N	unknown	unknown	gnl\|CDD\|274121
CP028158.1\|AVT33264.1\|7236893_7239617_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369642
CP028158.1\|AVT33255.1\|7219906_7221787_-\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
CP028158.1\|AVT34970.1\|7236351_7236570_+\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
CP028158.1\|AVT33260.1\|7231005_7231851_-\|fatty-acid-binding-protein-DegV	unknown	unknown	gnl\|CDD\|273257
CP028158.1\|AVT33265.1\|7241562_7243047_-\|GTPase-ObgE	unknown	unknown	gnl\|CDD\|237045
CP028158.1\|AVT33252.1\|7217809_7218571_-\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT33256.1\|7222133_7223117_+\|aminoglycoside-phosphotransferase	unknown	unknown	gnl\|CDD\|270703
CP028158.1\|AVT34971.1\|7239966_7240941_+\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|234866
CP028158.1\|AVT33259.1\|7229519_7230731_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377511
CP028158.1\|AVT33258.1\|7224595_7225570_-\|DNA-polymerase-III-subunit-delta	unknown	unknown	gnl\|CDD\|236130
CP028158.1\|AVT33253.1\|7218993_7219281_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT34967.1\|7225815_7228263_-\|competence-protein-ComEC	gnl\|CDD\|377126	pfam03772, Competence, Competence protein. Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.	6.33771e-52
CP028158.1\|AVT33262.1\|7233067_7233664_-\|nicotinic-acid-mononucleotide-adenylyltransferase	gnl\|CDD\|234611	PRK00071, nadD, nicotinate-nucleotide adenylyltransferase.	5.14559e-102
CP028158.1\|AVT34968.1\|7228535_7229357_-\|competence-protein-ComEA	gnl\|CDD\|224472	COG1555, ComEA, DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair].	6.16958e-31
CP028158.1\|AVT34972.1\|7240944_7241442_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.30452e-13
CP028158.1\|AVT34969.1\|7232569_7232968_-\|ribosome-silencing-factor	gnl\|CDD\|376779	pfam02410, RsfS, Ribosomal silencing factor during starvation. This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits. This family is structurally homologous to nucleotidyltransferases.	4.89997e-40
CP028158.1\|AVT33261.1\|7231940_7232573_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.91369e-59
CP028158.1\|AVT33263.1\|7233758_7236281_-\|aminopeptidase-N	gnl\|CDD\|274121	TIGR02412, Aminopeptidase_N, aminopeptidase N, Streptomyces lividans type. This family is a subset of the members of the zinc metallopeptidase family M1 (pfam01433), with a single member characterized in Streptomyces lividans 66 and designated aminopeptidase N. The spectrum of activity may differ somewhat from the aminopeptidase N clade of E. coli and most other Proteobacteria, well separated phylogenetically within the M1 family. The M1 family also includes leukotriene A-4 hydrolase/aminopeptidase (with a bifunctional active site).	0
CP028158.1\|AVT33257.1\|7223273_7223540_+\|30S-ribosomal-protein-S20	gnl\|CDD\|376586	pfam01649, Ribosomal_S20p, Ribosomal protein S20. Bacterial ribosomal protein S20 interacts with 16S rRNA.	1.83245e-27
CP028158.1\|AVT33255.1\|7219906_7221787_-\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0
CP028158.1\|AVT34970.1\|7236351_7236570_+\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	1.82752e-14
CP028158.1\|AVT33260.1\|7231005_7231851_-\|fatty-acid-binding-protein-DegV	gnl\|CDD\|273257	TIGR00762, DegV, EDD domain protein, DegV family. This family of proteins is related to DegV of Bacillus subtilis and includes paralogous sets in several species (B. subtilis, Deinococcus radiodurans, Mycoplasma pneumoniae) that are closer in percent identity to each than to most homologs from other species. This suggests both recent paralogy and diversity of function. DegV itself is encoded immediately downstream of DegU, a transcriptional regulator of degradation, but is itself uncharacterized. Crystallography suggested a lipid-binding site, while comparison of the crystal structure to dihydroxyacetone kinase and to a mannose transporter EIIA domain suggests a conserved domain, EDD, with phosphotransferase activity. [Unknown function, General].	5.98048e-93
CP028158.1\|AVT33265.1\|7241562_7243047_-\|GTPase-ObgE	gnl\|CDD\|237045	PRK12296, obgE, GTPase CgtA; Reviewed.	0
CP028158.1\|AVT33254.1\|7219358_7219910_-\|hypothetical-protein	gnl\|CDD\|240037	cd04681, Nudix_Hydrolase_22, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	3.59414e-17
CP028158.1\|AVT33256.1\|7222133_7223117_+\|aminoglycoside-phosphotransferase	gnl\|CDD\|270703	cd05154, ACAD10_11_N-like, N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins. This subfamily is composed of the N-terminal domains of vertebrate ACAD10 and ACAD11, and similar uncharacterized bacterial and eukaryotic proteins. ACADs are a family of flavoproteins that are involved in the beta-oxidation of fatty acyl-CoA derivatives. ACAD deficiency can cause metabolic disorders including muscle fatigue, hypoglycemia, and hepatic lipidosis. There are at least 11 distinct ACADs, some of which show distinct substrate specificities to either straight-chain or branched-chain fatty acids. ACAD10 is widely expressed in human tissues and highly expressed in liver, kidney, pancreas, and spleen. ACAD10 and ACAD11 are both significantly expressed in human brain tissues. They contain a long N-terminal domain with similarity to phosphotransferases with a Protein Kinase fold, which is absent in other ACADs. They may exhibit multiple functions in acyl-CoA oxidation pathways. ACAD11 utilizes substrates with carbon chain lengths of 20 to 26, with optimal activity towards C22CoA. ACAD10 may be associated with an increased risk in type II diabetes. The ACAD10/11-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).	3.31601e-10
CP028158.1\|AVT34971.1\|7239966_7240941_+\|tryptophan--tRNA-ligase	gnl\|CDD\|234866	PRK00927, PRK00927, tryptophanyl-tRNA synthetase; Reviewed.	6.13313e-155
CP028158.1\|AVT33259.1\|7229519_7230731_-\|hypothetical-protein	gnl\|CDD\|377511	pfam05426, Alginate_lyase, Alginate lyase. This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyze the depolymerization of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end. This family adopts an all alpha fold.	2.96612e-10
CP028158.1\|AVT33264.1\|7236893_7239617_+\|hypothetical-protein	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	5.36474e-26
CP028158.1\|AVT33258.1\|7224595_7225570_-\|DNA-polymerase-III-subunit-delta	gnl\|CDD\|236130	PRK07914, PRK07914, hypothetical protein; Reviewed.	6.38969e-98

>CP028158.1|AVT33259.1|7229519_7230731_-|hypothetical-protein
MIAAGVLLSTAVIVPYAGPGAAAPAAQAAPPGAEVRIAAPPTFTHPGVLVSRPQLDFVRGRVNAGAQPWKGAYDQMMASAFASLSRTPKPRAVVECGSYSNPNNGCTDERQDALAAYSLALAWYITQDSRYAEKAIQIMDAWSATIRDHTNSNAPLQTAWAGSSWPRAAEIIRYTYGGWSSAGISRFGAMLRDVYLPEIINGNATSNGNWELSMMEASLGIAVFLEDRAVYDRAVGKFRDRLPAFLYLSSDGAYPRGPAGSSIDTRAEIVSYWHDQEVFSDGLSQETCRDFTHTGYGISAISHVAETLRHQGQDIYPEIQDRLRHALGFHARYELGDAVPSTLCGGSLTLGLGPVTEVAFNALNNRRGIPMTRTQQLTERQRPAGTNYLFVAWETLTHAGNPN
>CP028158.1|AVT34968.1|7228535_7229357_-|competence-protein-ComEA
MSDDDETVVRQRLSRLLGDRAIPAERSAAGPAPAGTGPDPSADPPAEPGRLAGPGAFDPAGPGAFDPGRRGVKALAVVAVVVVLGAAGWAWLSRPRTEPVAPPPASAATFAPASSTSGAAVGAAEVVVAVAGKVRRPGLVRLPAGARVADALESAGGALPGVDVALLNLARKVTDGELILVGVTPPPGAGPAGAGPPGAPGGATGAQPGGGKVNLNTATVAQLDTLPGVGPVLAQRIVAHREEHGGFRSVADLRQVTGIGDARYEDLKDLVTV
>CP028158.1|AVT34967.1|7225815_7228263_-|competence-protein-ComEC
MRASTASPPGPTAGPPDAGHDAAEAAEPPRRPPDLRLAGLAVGAWLSALAGLLIGTGPAVLVAVLAGGAALVLACRSTRRLPAVPGRHGWVVVTVLLGVVCGSVATAARSGVRDAPSIARLAEERARVSAELVVREDPRPIGGVAGRPATYLLSTRLVWAAGEAGNDRVSASVRILVLASDPDWRGLLPGQRVTTTGRLAPPRGGDLTAAVLTVSTPPVLRGTPSWAQRAAGTLRAGLQRACAPLPTEPGGLLPGLVVGDTSRLEPAVEEDFLTTGMTHLTAVSGSNVAIVVGLVLLLARWGRAGPWLAAVLCGTALVGFVILARPSPSVVRAGTMGAIGLLALAVGRPRAALPALASAVTVLVLVDPELAGDPGFALSVLATGGLLLLAPRWRDALRQRGVPAGAAEALAIPAAAQLACAPVVAGLSGTISLVAVPANLLAVPAVAPATVLGVTAAVLSPFWPAGAEGVAWLGSWPAWWLVLVARYGARLPAGTLPWLDGVPGGLLLGALTVALLVAARRPPVRRLVAVVAAAVLVGALPVRLIATGWPPTGWVVVACAVGQGDSLVLPVGVGRAVVVDAGPDPGAVDRCLRRLGVREVSLLVVSHFHADHVQGVDGVFRGRRVAAVVVPQWLEPVEGRGTVERAASANGVPVGAAGAGWTYAAGPVTLTLLGPPHPIRGTRSDPNNNSLVLRAEVHGVSILLTGDAETEEQQALLEVVPVARLRADVLKLAHHGSAYQEPAFLDAVRPAVALVPVGADNGYGHPNAGVLARLSRAGARVLRTDEQGDLAVVEPGSGRLSVAVRGLDPGDPSTR
>CP028158.1|AVT33258.1|7224595_7225570_-|DNA-polymerase-III-subunit-delta
MTPASLAPVVLVLGDEELLATRAVAGVVDAARAADPDVDVHDHEAGALGPGEIAELLGPSLFGGRRVLIVRAGQDARKDLAAALLAYAKNPDPEVQLVVAHAGGAKGKAFADGLRAAGAEVVPAAKLKSHRDRVAFVRDEIRRGGGRCTDDAAEALIAAVGNDLRELASACSQLLADTDGRIGVDTVARYYRGRAEVSGFTVADAAMAGDVPGALEALRWALHVGVDPVPIADAIADGVRTVARVSSAGRGSAYQLASSLGMPPWKIEKAQRVGRGWTPEGLADAMYAAAECNAAVKGGSDDRGYALERAVVAVAAARRASASR
>CP028158.1|AVT33257.1|7223273_7223540_+|30S-ribosomal-protein-S20
MANIKSQIKRNRQNEKRRLRNKSVKSSLKTAIRKFHEATESGDSAKATELMRDASRKLDKAVSKGVIHQNQAANRKSAIAKRLQSLSA
>CP028158.1|AVT33256.1|7222133_7223117_+|aminoglycoside-phosphotransferase
MAAISVPPRPYDATAVRPGWADLPADLRAAITARLGARVGWAGTAGGGFTRGFAGVLQTVAGDRVFVKAASLVDQRHLSDWYAREAAITAVLPAGLAVARPRWTLTAAGYHVICLDAIDGRMPGLPWAPAELAATLDAYATAAAALRQPPVELAALGVPRLADLARADLAWWTELAAGRETLPEIPAVAGHRLPELAALEARLPGYADRPSMIHGDLRVDNVLLDRAGVAWLCDWTWLCYGPPWFDLASLLVTAYASGLDADALFATHPAGLDAPADGLDAALAALSGYWLVRAAAGSGTGSPHIRAHQRWSAQTALDWLAERQGWR
>CP028158.1|AVT33255.1|7219906_7221787_-|elongation-factor-4
MPPTPDSGANSPGATDPGRIRNFCIIAHIDHGKSTLADRMLQLTGVVDPRQMRAQYLDRMDIERERGITIKSQAVRMPWTVREGDQQGEEAVLNMIDTPGHVDFTYEVSRSLAACEGAILLVDAAQGIEAQTLANLYLALENDLHIIPVLNKIDLPAAQPDKYAEELAHLIGGDPSDCIRVSGKTGEGVPYLLDEIVRQFKPPVGDAKAPARAMIFDSVYDVYRGVVTYVRVIDGRIEARDKIKMMSTGAVHELLELGVISPEMQKAGALGVGEVGYLITGVKDVRQSRVGDTVTINARPASEALGGYKDPKPMVYSGLYPIDGSDYPALRDALDKLKLNDAALSYEPETSAALGFGFRCGFLGLLHLEIIGERLEREFNLDLISTAPNVVYRVGLEDGKEVTVTNPSEYPTGKVAEVYEPVVRATVLTPNDYVGAVMELCQGRRGSLQGMDYLSADRVELRYTLPLAEIIFDFFDQLKSRTKGYASLDYEPTDEQRSDLVKVDILLNGEPVDAFSAIVHKDKAYNYGVNIAAKLQKLIPRQQFEVPIQAAIGNRVIARETIRAIRKDVLAKCYGGDISRKRKLLEKQKEGKKRMKMVGRVEVPQEAFIAALSTSDSGDGKGGGKK
>CP028158.1|AVT33254.1|7219358_7219910_-|hypothetical-protein
MIPRGYGPGASFCPRCAAALPGPAPTTCTRCGYQLFVNARPTVGLVILDRPSSGSAAPAVAEPRFLALRRAAEPMIGRWETPGGFCDGWEHPAEAAVREAREELGVSITLGDHLGMYVGSYEFQDEILPVLDNFFLATLDDPRVVLDPAESAELSWFSLVDPPPLAFGTMDVAVREAARRLGA
>CP028158.1|AVT33253.1|7218993_7219281_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MELTVWGIITALIVGLVIGALGRLVVPGRQDIPIWLTMLIGVGAALLGTVIARAAGIATETAGIDWMELLIQVALAAIGVALVAGVGRRRRVSRY
>CP028158.1|AVT33252.1|7217809_7218571_-|hypothetical-protein
MYLEAYTPLVEEWFSALRVSSGLRELRQDGPGRDLVENLQRLDQLFRDLVDGMFAHPTPVLERAVAVVAAHREAVVWEDQLVPSPGAGAEELAASLRHKFKRNISLALLEALICLESALSYGRDTLGLSGETLERTLRGSTSMLASLSVLHDQQEMARMRQLTGDPTEIQHPRFTVADIVRGAFRIGPDKFRAVGPEGQQRIRFGSVPPHGVEVTSPTMKCPAHRLTNEEGQPLNNELWALLVDVYRMSGRLA
>CP028158.1|AVT33260.1|7231005_7231851_-|fatty-acid-binding-protein-DegV
MPVAVVTDSTAYLPAELADRHRLTVVPLIVVLDGTPGREGVDVGPADAAQALAARRFAMSTSRPAPEEFVETYRRLLAEGADGVVSVHLSAELSGTVEAARLAAAELGPRVSVVDARSTGMGLGFPALAAASAAARGAGLTEVRRAALDAIDRTSTFFYVDTLEFLRRGGRINAAEALLGTALSVKPILHMADGGIALRDRVRTAGRGLARLVDLAVEAAGSGEVEVALHHLAVPGRAAELAEKLGGRLGDRLRASYVTEAGAVIATHTGPGLVCVVVHRL
>CP028158.1|AVT33261.1|7231940_7232573_-|histidine-phosphatase-family-protein
MTRLIVWRHGNTDWNAANRVQGQLDVPLNDLGREQATEAAPLLAGLRPDAIVASDLRRAADTAAALAALTGLPIRTDPRLRERFYGQWQGLLMTEVAQRFPAEHARWRSGDPDPGAEVESLDDLGKRVGTALQEAADAVPGGTVVIATHGGGARQGCGYLLGWDSTVLRSVGSLNNCHWTELRHDEVRGWQLRGHNVGRLVAPGPAPAPV
>CP028158.1|AVT34969.1|7232569_7232968_-|ribosome-silencing-factor
MTASDRARELATAAAQAAADKKAQDIVIIDVADQLVITDAFLLASAPNERQVTAIVDAIEEALLALPEKAKPVRREGERAGRWVLLDYVDLVVHVQHSEEREFYALDRLWKDCPTIPFVDRDLVEAEAGIAE
>CP028158.1|AVT33262.1|7233067_7233664_-|nicotinic-acid-mononucleotide-adenylyltransferase
MEADIRRIGIMGGTFDPIHHGHLVAASEVADRFELDEVVFVPTGQPWQKADEPVSSAEDRYLMTVIATASNPRFQVSRADIDRGGPTYTVDTLRDLHSEYGPKVQLFFITGADALEKILSWKDLDQMFELAHFIGVTRPGFVLSDAHLPADTVSLVEVPAMAISSTDCRARVAAGGPLWYLVPDGVVQYIAKRRLYRG
>CP028158.1|AVT33263.1|7233758_7236281_-|aminopeptidase-N
MPSLTRVAAAERAALLTVESYDIELDLTGSAERFRSTTTVRFRAATPGAGTFVEVRPARLLGVRLNGAALDPAALDDNQYPLTGLAAENTLVVEAEMAYSNSGEGLHRFVDPADGETYLYAMSGMDNAQRIFACFDQPDLKAPVTLAVVAPEEWIVAGNGRLDSGPVAGRWVFAPTPPLATYLVSLVAGPYAVRRAEHDGIPLGLYCRRSLTEHLDRDAEEILTVTRQCLDRLHRLFGVRYPFGKYDQAFVPEFNMGAMENPGLVTFRDEFLPRSAVTDAEREQRANSIAHEMSHMWFGDLVTLRWWDDLWLNESFAEYFGTRITAEATRFDRAWTTFALRRKAWGYAADQRPSTHPVAPTEVADATEALANLDGISYAKGASVLRQLVAWLGDDAFLAGLRGYFAAHRFGNATLADLLAALAAGSGRDLAGWAAVWLRQPQLNTLRTEVRLRDDGHYAEVALVQTAPPEHPVLRPHRIGVGLYDPDPAGGGTALRLRDRVEVDLDPAADGGRTVLPGLTGQPAARLLLPNDGDLTFAKVRLDAASVAAVPAALPELADPLTRALLWAEALDAVTDGERPVADLVALVVAALPAETEVVVVQDVLARTCDLLDRHLQPEVRPAALEQLAGACARLLAVAPPGGSGQLAAARGWISSTVEVARLTGWLAGKEVPDGLAVDAELRWAVLGRLAVLGAVGEPEVAAEQAEDGSASGAERAATCRAALPDPAAKEHAWRLLVGETSLSNRLLEATARGFWQPEQAELTDSYVERYFAEMPAAARRRTPWVADRVAALAYPRYAVSARTRELAAALLGRDDLPSGLRRVVVDEDDDLRRALAARR
>CP028158.1|AVT34970.1|7236351_7236570_+|DUF397-domain-containing-protein
MAQHPKGDFDLSRAVWQRAEGDDSEGAVEIAFVDDLIGMRNSAEPDGPVLVFTQAEWDAFVAGAQDGEFDLD
>CP028158.1|AVT33264.1|7236893_7239617_+|hypothetical-protein
MPSSARPSPVNRLLRTGVAVALVAALAAPISGTAPAAAVVLPTGFQEQVVFTGLNQPTNIEFAPDGRVFVAEKGGRIKVYDDLADTTATVFADLSANVHNQHDRGLLGLALHPDFPTQPYVYVLYAYDAPPGQTAPYWNDNCASVGGTNGGRCIVTGRLSRLTAAGNTMTGTEQVFIDDWCQQYASHATGDLRFGADGMLYATAGDGASYDLVDYGQLGTPPNPCADPPGGTMSPPTAEGGALRSQDSRTTADPTSLDGTVLRLDPLTGAAAPGNPSAASPDPNTRRIVAQGLRNPFRFTIRPGTNEVWAGDVGWTRWEEVNRVVDPTASVTNFGWPCFEGAGRQSGYDSANLDMCESLYSGAGQTAPFYTYDHAARVVAGEACPTGSSSVSGAAFYPAAGGSYPAEYAGALFFSDYSRDCIWAMLPAAPGGLPVASSRRTFGSAAANPVDLAMGPGGDLYYVDHAGSVRRIRYFPGNQPPVASIAASPTSGTAPLTVNFDGTGSSDADPADAGRLRYEWDFTNDGTVDATTATATYTYPAGGPYTARLTVYDTLNASGTQTVPIQTGNSMPTAVIDSPGGDFTWAVNDTISFTGHATDPDQGTLPASALHWRMLLHHCYTLDNCHIHTLQDFTGASGSMFGPDHEYPSYLELVLTATDSGGLSHSTSVRLDPKTVDLTFNSSPPGLQLVFGATAQAAPFTRTVIQGSSNTVSAVTPQTLGGVPYVFGSWSDGGAQTHVITAPTTPTSYTATYNPQSGSTRLPQSAWTVAGADSQETLLVNGRANNVRDGSSSSIWHTQRLLSNPAHPHWIDLDLGSARTVNRLYYLPRQGSNTGGRITGYEVYVSNSRSSWGTPVATGTFPNSAAEQTVTIPPTSGRYLRLRALGEVSGNRWTSVAELNVGVVPTG
>CP028158.1|AVT34971.1|7239966_7240941_+|tryptophan--tRNA-ligase
MRRITGLKPTGHLHLGNLVGAIRPIVAGQYRAETIVFLADLHALTVTHQPAQIRALTLEQATVLLAAGLDPDRALLYVQSQVPQHTELHYLLECATGYGEAHRMIQFREKSARHGQVRLSLLSYPVLMAADILLHDVQEVPVGDDQSQHLELTRAVATRFNTRYGDTFTIPRAVHPTVSARLMDLADPTAKMGKTSSSEAGTVFLLDPPEVIRRKVLRAVTDPGRTVEYDPQRRPGVANLLEILATCLGGSPADLAAGYGSYAQLKNAVAEAVEAMLRPIRLRYTELARDPGYVRRVLADGADRARDNATDTVHRAKRALGLLP
>CP028158.1|AVT34972.1|7240944_7241442_-|GNAT-family-N-acetyltransferase
MLIESRSSSDPELAALVVAQQRELREADGGLDGQVFMPHDDARYLVGVIAGRAVACGAIQTLDRDTAEVKRMYVRPAHRGQGLARQMLGALEELALRAGQTVLRLETGSYLPGAIQLYLSSGYVEIPAYGEYTSNPYSVCFEKRQPATSGRERLPGRAEATVSLG
>CP028158.1|AVT33265.1|7241562_7243047_-|GTPase-ObgE
MTTFVDRVVLHLQAGDGGHGCVSIHREKFKPFGGPDGGNGGHGGSVSLVVDPQVHTLLDFHFRPHVKAENGKGGAGSNRDGANGHDLVLKVPDGTVVHAMDGTVLADLVGAGTTFEVARGGRGGRGNASLANARRKAPGFAELGEPGDRLDVVLELKSVADVGLVGFPSAGKSSLISVLSAAKPKIADYPFTTLVPNLGVVRVDEHTFTVADVPGLIPGAATGKGLGLEFLRHIERCAVLVHVVDAANPEPGRDPLADIDAIEAELSEYGGLADRPRLVVLNKIDVPDGRDLAEIVRPDIEARGLRVFEVSAVTREGLRELTFALAELVEQSRAVAPDLEPTRIVIRPVAVDDAGFTIETAPDGAYVVRGQRPERWVKQTNFDNEEAVGYLADRLARLGVEEQLAKAGAEPGSLVRIGEREFDWQPTLYAGAEYVPSARGTDSRLAEKVTRPTAAERLAARKARRQRPPEEATPDPTPDGTVQRPDSGTAPDAD

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Crispr_ID: CP028158_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_14

7586411-7586508

Unclear

Consensus_repeat	Method
CGAGCCCCGCAGTCGCGAACGGAAGG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of CP028158_14

>merge|CP028158|14|7586411-7586508|CRISPRCasFinder
CGAGCCCCGCAGTCGCGAACGGAAGGTGCGGCTGTGAGCGCGAGGAGTGAGCCGGTGTTGCGAGCCCCGCAACGAGCCCCGCAGTCGCGAACGAAGGA

>CP028158|14|14|7586411-7586508|CRISPRCasFinder
CGAGCCCCGCAGTCGCGAACGGAAGG	TGCGGCTGTGAGCGCGAGGAGTGAGCCGGTGTTGCGAGCCCCGCAA
CGAGCCCCGCAGTCGCGAACGAAGGA

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT33512.1\|7578856_7579636_-\|DeoR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
CP028158.1\|AVT33513.1\|7581796_7583326_-\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|180124
CP028158.1\|AVT33517.1\|7587279_7590066_-\|phosphoenolpyruvate-carboxylase	unknown	unknown	gnl\|CDD\|366019
CP028158.1\|AVT33519.1\|7590726_7591539_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367243
CP028158.1\|AVT35012.1\|7579635_7581657_-\|beta-galactosidase	unknown	unknown	gnl\|CDD\|367090
CP028158.1\|AVT33509.1\|7576046_7576490_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319914
CP028158.1\|AVT33522.1\|7598149_7598911_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT33508.1\|7574498_7575716_+\|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl\|CDD\|236226
CP028158.1\|AVT35013.1\|7586514_7587225_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224196
CP028158.1\|AVT33518.1\|7590258_7590642_-\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT35014.1\|7594415_7598057_+\|transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
CP028158.1\|AVT33511.1\|7577780_7578860_-\|galactose-1-phosphate-uridylyltransferase	unknown	unknown	gnl\|CDD\|238341
CP028158.1\|AVT33510.1\|7576560_7577733_-\|serine-hydrolase	unknown	unknown	gnl\|CDD\|365903
CP028158.1\|AVT33514.1\|7583590_7584586_+\|ABC-transporter	unknown	unknown	gnl\|CDD\|224054
CP028158.1\|AVT33516.1\|7585466_7586378_+\|ABC-transporter	unknown	unknown	gnl\|CDD\|224054
CP028158.1\|AVT35015.1\|7600175_7601531_+\|cellobiohydrolase	unknown	unknown	gnl\|CDD\|376532
CP028158.1\|AVT33520.1\|7591707_7593126_-\|esterase	unknown	unknown	gnl\|CDD\|130316
CP028158.1\|AVT33523.1\|7598984_7599989_+\|nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|237065
CP028158.1\|AVT33515.1\|7584585_7585470_+\|ABC-transporter-permease	unknown	unknown	unknown
CP028158.1\|AVT33521.1\|7593191_7594115_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225117

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT33512.1\|7578856_7579636_-\|DeoR-family-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.18873e-81
CP028158.1\|AVT33513.1\|7581796_7583326_-\|adenylyl-sulfate-kinase	gnl\|CDD\|180124	PRK05537, PRK05537, bifunctional sulfate adenylyltransferase/adenylylsulfate kinase.	3.41525e-140
CP028158.1\|AVT33517.1\|7587279_7590066_-\|phosphoenolpyruvate-carboxylase	gnl\|CDD\|366019	pfam00311, PEPcase, Phosphoenolpyruvate carboxylase.	0
CP028158.1\|AVT33519.1\|7590726_7591539_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	5.41716e-15
CP028158.1\|AVT35012.1\|7579635_7581657_-\|beta-galactosidase	gnl\|CDD\|367090	pfam02449, Glyco_hydro_42, Beta-galactosidase. This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	0
CP028158.1\|AVT33509.1\|7576046_7576490_-\|glyoxalase	gnl\|CDD\|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	4.54583e-40
CP028158.1\|AVT33508.1\|7574498_7575716_+\|NADP-dependent-isocitrate-dehydrogenase	gnl\|CDD\|236226	PRK08299, PRK08299, NADP-dependent isocitrate dehydrogenase.	0
CP028158.1\|AVT35013.1\|7586514_7587225_+\|ABC-transporter-permease	gnl\|CDD\|224196	COG1277, NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only].	0.000176531
CP028158.1\|AVT35014.1\|7594415_7598057_+\|transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
CP028158.1\|AVT33511.1\|7577780_7578860_-\|galactose-1-phosphate-uridylyltransferase	gnl\|CDD\|238341	cd00608, GalT, Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme contains two identical subunits. It also demonstrates that the active site is formed by amino acid residues from both subunits of the dimer.	1.4061e-119
CP028158.1\|AVT33510.1\|7576560_7577733_-\|serine-hydrolase	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	6.10326e-56
CP028158.1\|AVT33514.1\|7583590_7584586_+\|ABC-transporter	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.34812e-84
CP028158.1\|AVT35015.1\|7600175_7601531_+\|cellobiohydrolase	gnl\|CDD\|376532	pfam01341, Glyco_hydro_6, Glycosyl hydrolases family 6.	2.33332e-90
CP028158.1\|AVT33520.1\|7591707_7593126_-\|esterase	gnl\|CDD\|130316	TIGR01249, Putative_proline_iminopeptidase, proline iminopeptidase, Neisseria-type subfamily. This model represents one of two related families of proline iminopeptidase in the alpha/beta fold hydrolase family. The fine specificities of the various members, including both the range of short peptides from which proline can be removed and whether other amino acids such as alanine can be also removed, may vary among members.	3.49781e-10
CP028158.1\|AVT33523.1\|7598984_7599989_+\|nucleoside-triphosphate-pyrophosphohydrolase	gnl\|CDD\|237065	PRK12334, PRK12334, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	7.88754e-93
CP028158.1\|AVT33516.1\|7585466_7586378_+\|ABC-transporter	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.76577e-76
CP028158.1\|AVT33521.1\|7593191_7594115_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.58624e-14

>CP028158.1|AVT33516.1|7585466_7586378_+|ABC-transporter
MSNLELAGVSRWYGNVVAVNDVSMNLGPGVTGLLGPNGAGKTTVLHMMAGFLAPSKGTVTLDGEPTWENPEVYRRLGLVTERESVYDFLSAYEFALASARLHRLPEPDAAARRAIELVELTDAQDRRIGTYSKGMRQRARVAAALVHDPQVLLLDEPFNGMDPRQRLHMMELLHSLGEQGRTILFSSHILEEVEQVSGTVQVIVSGRLAASGDFRTIRRLMTNRPHVFAVQSSDDRRLAVELIGQPSVTGVDLNRDGLTVRAGDYGSFTRALPKIALASGIRIRRLLPSDESLESVFSYLVEA
>CP028158.1|AVT33515.1|7584585_7585470_+|ABC-transporter-permease
MTTLDAPRTDRPAGVIHDIGYQRYDGPRLGRRHLVGALYLHSLRTAFGLGRTFKAKIFPWLIVGVFGVVAAVLTAVRAQIGESPLSYAEFPEVLSVLIIFFCAIVAPELASRDLHSGVLPLYFARPLHRSDYALVKLAALISATFLTIGVPLTVMFAGAAFMVDGIGAVWDELGDFLPALGYVAVHAIVYSVLALLVASLVRRRAVAAGAIVGAFLLTTPVVAVLSVMPYEAANQLAGLASPVTLVAGIGDWAIDASSDLDVGRYGPLYGLVAVGFVVAGTLLLLARYRKVAAR
>CP028158.1|AVT33514.1|7583590_7584586_+|ABC-transporter
MTLIATQSLTKTYGNRVTALSDLTVTVEPGIVGLVGANGAGKSTFIKIMLGLLEPTGGQARVLGLDPLVDGHQVRARVGYMPEHDCLPPDLSAAEFVTHMGRMSGLPKTTARERASETLRHVGLYEERYRQVGGYSTGMKQRVKLAQALVHDPDLLLLDEPTNGLDPAGRDAMLALIERIGTEFGISVLVCSHLLGEVERICDALVAIEGGKLLRSAQLADMTAVTEVLSVEVSEGTAELAARLAAAGLPVRQDGRLLLVPMLDPGAAAAGAQARDSALDRTYDLILTAVAELDLPLHRLDQRRHRVVELFATDPARVAEPIATGTALEGA
>CP028158.1|AVT33513.1|7581796_7583326_-|adenylyl-sulfate-kinase
MSNGWVLPDELLRDAPAYTPRPYELADLELLLSGAYAPLTGFMGRADLASVARRGRLADGSGWPVPVTLQVPADLVSGIDLNNPVERGLVLTDPEGAPTALLEVADLWPTTQGWFGVGGPVRRIGDGGHGPFQRLRRPPAEVRELLPPGRVLGVIADRPLHRPQLAQIAHAVRTLAAHLLILIPVANTSSDGLPPEVLVRSIFGARDRMPPATIVAVPIARRGDDIWDALLRARVARAYGVTHVLSTTEMLTGGGLRMLVPRELAYDNRDGQWRWRDDIPPRNRRLPLGQEEIEDLLDRGFPLPEWHTPPTVAKELTRARPPRRHRGLVVFFTGLSGSGKSTIARGLADALRESGDRTITLLDGDVVRRELSAGLGFSRADRDLNVRRIGWVAAEVARHRGLAICCPIAPYHRARAIAREMARSAGAGFVLVHVATPLAVCERRDRKGLYARARAGQLTGMTGVDDPYEEPTDAELVLDTTDLTVEECVHLLLAHLTETGWVESRLQPA
>CP028158.1|AVT35012.1|7579635_7581657_-|beta-galactosidase
MPNIEGLSYGGDYNPEQWPEEVWPQDVALMREAGVNLVTVGVFAWAWLEPAAGRYDFDRLDRIMDMLHAGGIRVCLATATASPPPWFSHAHPETLPVDADGRRLTYGSRQAICASSPVYRRAAVALTEQLARRYANHPALAVWHVHNEYACHNAHCYCDTSAEAFRGWLQARYGDLDGLNTAWGTAFWSQTYTDWAQVQPPRATPTSSNPTQVLDFKRFSSDEHLACFTAERDTLHRLSPGIPVTTNLMTASCVNLDYWAWGRELTGADRLLSNDHYLLGEHPLEPPAQIAFAADLSRSLAGGPWLLMEHSTSAVNWQPRNLAKPAGQLGQDALAHVARGSEGALFFQWRASRAGSEKWHSAMLPHAGTDSKIWREVVGLGRHLRALAEIEGSRTEAEVAVLLDYSSVWAQEAANQPSTDMVAFDEIRRWHSALWRAGITADLAAPGADLTGYKLVLAPALYLVDDAAIGNLTGYVRSGGTLVVGPYSGLVDERDRVRPAPLPGGFAELLGVRVEEFFPLPAAGTVRLDDGTSAEVWTEALVAADAEVLVRYDNGPVAGGPAVTRRSADGGAAWYLGTRLEQTALGRLLARIADEAGAAAAAPAVPGVEQIRRRHPDGRSYLFLFNRSDRPAEVDAAGTDLLTGTRWAGPTTVEPHGVAVLAQRPEPEPTGAP
>CP028158.1|AVT33512.1|7578856_7579636_-|DeoR-family-transcriptional-regulator
MLAQQRQEAILDRVRTAGGVRVTELAGEFGVSDMTIRRDLEALAERGLLAKVHGGATTARPGSTDEPGFAVKSVRQRPEKAAIAAEAARLVTPGMAVALSAGTTTAELARRLAGVPALTVVTNSIPVAEILHRSGRPDQTVVLTGGVRTPSDALVGPVAVATIRSLHLDLVFLGVHGMSERAGFSTPNLLEAETNRALLASADRLVVLADSTKWATVGISSFAELAEAHTVVSDTGLPEPAREILRAQVAELLLCEVTP
>CP028158.1|AVT33511.1|7577780_7578860_-|galactose-1-phosphate-uridylyltransferase
MRRMAVKLADGRELIYFDEHPDAVREGPDRRDLPLPPPASQLRYDPLVDEWVAVAAHRQGRIFLPPTDQCPLCPSTPERSSEIPAYDYDVVVFENRFPAFSDRPGDPPGQITPYTAVRPGTGRCEVVCFTADHSASFASLPPSRVRTVLEALADRTAALRGLPGVEQVFCFENRGVEIGVTLHHPHGQIYAYPFLPPRSRALLAAAGRHAERTGGRNLYADVLAAERAAGERVVLANEHWTAYVPAAARWPFEVHVAPHRPVPDIPALDDAERDAFGPLYLDLLRRLDRLFDRPLPYISAWHQAPVHADPALAHLHLQVFSIRRAADKLKYLAGSESAMGVFINDIAPERAAQLLRDAG
>CP028158.1|AVT33510.1|7576560_7577733_-|serine-hydrolase
MTDWTGPERLHAAMAARVADAELPGLVTVVARGDQVWVDPIGTLTVGGVAPMRADTIFRITSMTKPVLGVATMMLVEEGRLALDEPVDRLLPELAGRGVLRRLDGPLDDTVPAARPTTVEDLLTFRMGHGMIFEPSFQPAYPIVTATDELELAIGPPDPRTPHEPAEWLRRFGTLPLMHQPGERWQYDSAAGVLGVLVARAAGRPLPEVLRDRIFAPLGMVDTGFTVPAAHADRLAGFYAKDRATGALAERDVSGPAEWAAPPVFPSGANGLVSTAPDYLAFARLLLCRGVHQGRRLLSEESVKLITTNHLTPEQIASGGPVLDGYGWGYCVSVAVTPDEASAVPGGYGWTGGYGTAWFTDPHRDLIAIVLTQTADFLFDGGLAEFRKLA
>CP028158.1|AVT33509.1|7576046_7576490_-|glyoxalase
MEQRVHFVTVATRDLDRARDFYVEGLGWTPTLDVPDEILFFQVAPGVVLGLFEAEAFAADLGTAGALLPAPTGFTLSHNVASPAEVDRVLAQAAAAGATIVKSGRNAAFGGYHGYFSDPNELLWEVAHNPDWQVAEDGRVTLGPIEE
>CP028158.1|AVT33508.1|7574498_7575716_+|NADP-dependent-isocitrate-dehydrogenase
MAKIKVTNPVVELDGDEMTRIIWKQIRDQLILPYLDVDLHYYDLSIQYRDETDDQVTVDAANAIKQHGVGVKCATITPDEARVEEFGLKKMWRSPNGTIRNILGGVVFREPIIMSNVPRLVPGWTKPIIIGRHAHGDQYKATDFVVPGPGTVTITYTPTDGGAPVEMEVANFPGGGVTMGMYNFDDSIRDFARASFRYGLDRGYPVYLSTKNTILKAYDGRFKDIFAEVFEAEFKSDFDAAGITYEHRLIDDMVAAALKWEGGFVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGRTVEAEAAHGTVTRHYRQWQKGEKTSTNPIASIFAWTRGLAHRGKLDGTPEVSRFAEALEQVCVETVEGGQMTKDLALLISRDAPWLTTDEFMAALDQNLAKKLGA
>CP028158.1|AVT35013.1|7586514_7587225_+|ABC-transporter-permease
MSTVSWITARGLLGRRRFLLLFPLPLLLVGLAVLARATGIAPTEWGQPVVYALGLAVVLPVTALIVGTAVLGSEIDDGTLLHILTKPLPRWQIVLPKLAVATGVTALTVAIPLYVAGVLVESVRFGLGLAAASAVGALAYSAFFLALSLLTRRPVLLGLVYVLIWEGLLNSIVSGTRVLSVQHYVVTLTDRIAPTALLDGSVSLPVAIVMSAVFTVGFTLLAIRRLGRFSVAGETS
>CP028158.1|AVT33517.1|7587279_7590066_-|phosphoenolpyruvate-carboxylase
MTDQHDHDGPDAALRADIRRLGKLLGQTLARQEGPPLLDLVEEVRALVRHDAEAAAQRLGAMDVTTGTKLARAFSTYFHLANITEQVHRSRDLRRQRAAHGGWLDQAARLIRERGVPPEEIASVARRLSVRPVFTAHPTEAARRSILSKLRAVADELDAEAAAAILYGASDEGPASRRLAELLDLLWQTDELRLDRPDPTDEARNAIYYLRDLYAEAAPQVLDDLADTLRGLGVETAPTARPLTFGTWIGGDRDGNPFVTPQVTRDVLLIQYEHGIQATEAAMEALINEISVSRRLRGVSLDLSASLAKDLDALPEVAPRFRRVNAEEPYRLKARCVRAKLANTRRRLNQGTAHVPGRDYRGSADLLADLELMRASLARNSGQLTAVGRLASAIRTVAAFGPHLATMDIREHAEAHHVVLSQFYAQVGEVPEYSSLSRADRTKLLAEELAGRRPLSTMDTPLTEPARKTFDVFGTIREVQERFGVEVIESYIISMTLGVDDVLAAVVLAREAGLVDVHTGRARVGFVPLLETPAELDAGGELLDEMLSLPAYRAIVAARGDVQEVMLGYSDSNKEAGITTSQWSIHRAQRALRDVAARHNVRLRLFHGRGGTVGRGGGPTHEAILAQPYGTLDGEIKVTEQGEVISDKYTLPSLARENLELTLAAVLQSTLLHTTPRQPAEALDRWDATMDVVSGAAYRRYRSLVENPDLPAYFWASTPTELLGALNIGSRPAKRPNTGAGLSGLRAIPWVFGWTQTRQIVPGWFGVGTGLAAAREAGMADILAEMHRAWHFFGTFLSNVEMMLSKTDLNIARRYVDTLVPEPLHPIFEMIEAEYELTKREVLAITASPALLENSPVLQRTLAVRDTYLEPLHHLQVALLRQYRDSGAAGRAVATAPGGRRAPGDGTALERALLTTVNGIAAGMRNTG
>CP028158.1|AVT33518.1|7590258_7590642_-|hypothetical-protein
MRPRFARGKTTSRAHCRAGCTDGADDAVCTDGADGEVCTDGADGEVCTDGADGAVCTGRPGAGSRTGRITVAASCSGRADVGAARTRAPGRWVHGRGSSTVCAGKVCSPGPATALSPPPAISGRGGA
>CP028158.1|AVT33519.1|7590726_7591539_-|TetR-family-transcriptional-regulator
MPVERSGGGDPDRTLALLWTAQPSPGSPAAAGRPARGRPPRLTVPQIRQAAIAVADREGLATMSMARVAEELGVGTMSLYTYVPGKAELIDLMVDGVMADRDLPGPDDVRPTDWRTRIELYADRTRTMYQRHPWLREVSTVRPPLGPGLLAQQEYLLAALADLGLPARQTVAAGNAIVSFVDAAARQQAEADQLERTTGQSTDEWWSDRDSFWAEHFDVARYPAMNRTWEAGGFVDTPDAMADAYRFGLRLLLDGIQRAAGAAGRAPAEG
>CP028158.1|AVT33520.1|7591707_7593126_-|esterase
MRHRPLLLGRAGTALLGLLAVLAAGSPVAAAPPLSGPAALGNRPGLTDPRPCAEAAGFTCAELTVPLDRRGGTPGELRLRVAVAENADAPRGTLLLLSGGPGQPGPGLLSRLEPRFRYLMDDYRLVMIDQRGTGPAGIDCPQLQAEVGSSDITPASPEAIRGCAELLGRTRNFYTTADTVADLEELRRALGVHRWTLDGISYGTFVAQQYGLTYPHRVARMVLDSVVPQDTLDGLYLPSLHRVAWVLRTACREQSCGSDPAADVAETIRRYGNAVGIFDFLVIASIVDPKLTGETFYPVLPFLRMAAEGSPEPLMSAIDDLQGGENTPFAEYSSGLHAATVCADQTDAPWGDSTAPPGRRARALDRAVRQIRPGHVWPFPRETAAEQALISTCLHWPVSRPNPRPPRHTLTMPVLLLNGDRDLSTPVEWAVEQAARTPRGELVVIAGMGHSIQGRHPEGDSAVRRFLLGPTA
>CP028158.1|AVT33521.1|7593191_7594115_-|AraC-family-transcriptional-regulator
MSDSHDAMPGFRDAFAADGRLQARWRWLGCPDGMGLYEVRCHNTRRGWEPARPSGHFTVHLARSGGYLRRLNGRERFVDPTSALFLKPSDDLTISHPLGCGDSYTVIEVDPELLVGWADGERWLTGAGWEGRLRADLDLEHRALVADSLRGTDRFELTERTHRLLGRLLAAGPDRPGEELDRAVRRRPGTLAAHRRLTDRVREVVSGGGYALGLTELARQVHCSPHHLSRVFQWTTGQSLTAYRNQLRTRAVLTALAAGEVASLRGLAAEYGFADQAHLTRTLRQQLGHSPTQLRRLLATTSGPARR
>CP028158.1|AVT35014.1|7594415_7598057_+|transcription-repair-coupling-factor
MLTGLLTAALRDPALARARSLARTGGPDADGLDLTAPPALRPFLVAAVAAGEEAGGAGRPVLAVTATTREADDLAAALGSLLPPEQVVVYPAWETLPHERLSPRSDTVGRRLGVLRRLAHPDLAEHPGPVRVVVAPVRSVLQPQLKGLGDLEPVRLAAGAEAGLEETARRLTDLAYARVDLVTKRGEYAVRGGILDVFPPTDEHPSRVEFWGDEVEEIRTFAVADQRTIEAVPALWAPPCRELLLTEPVRRRAAELAQQHPELAEILDKLAEGIPVEGMESLAPALIGADSLELVLHCMPAGSHVLLCDPERIRTRAHDLVRTSAEFLEASWAAAAVGGQAPVDLGAAAFKTLAEVRATAATLGQPWWSASPFGLVEAAPGPAATVEPWAVEPEPEVTVVPDTGESVALHAQPVPLYHGETARVVDDLKRWVGDGWGVALVFEGHGPAQRAVEVLRDAGLGAALTEEVPAPPASGELLVTCGSLNHGFLDSTSRIAVVTGNDITGGRGSSTRDMRKMPSRRRNTIDPLELRAGDYVVHEQHGIGRYVELVQRTVNGADREYLVIEYAASKRGQPGDRLFVPTDQLDQLSRYVGGEQPTLHKMGGAEWQKAKARARKAVKEIAAQLVQLYAARKASKGYAFAPDTPWQRELEDAFPYTETPDQLAAIEEVKRDMEQSTPMDRLICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLAQQHYNTFAERMGQFPVQIRQLSRFQTPKEAERTLEAAADGSADIVIGTHRLLQSATRFKQLGMVVVDEEQRFGVEHKEHLKTLRTAVDVLTMSATPIPRTLEMAITGIREMSTIATPPEERHPVLTFVGAYDDKQVAAAIHRELLRDGQVFYLHNRVESIDRAARRIRELVPEARVAVAHGQMGEDALEKVMVGFWEKEYDVLVCTTIVESGIDIPNANTLIVERADLLGLAQLHQIRGRVGRGRERAYAYFLYPPEKPLTEHAHERLATIAQHTELGAGMYVAMKDLEIRGAGNLLGGEQSGHIEGVGFDLYVRMVGEAVQAFKGERPEEEADIKIDLPVDAHLPHDYIGVERLRLEMYRKLAEARDAERLAEVVAEMTDRYGEPPEQVANLVAVARFRLLARAYGLTDVSAQGRHLRFSPLPLPDSKQLRLKRYHPDAVYKSATDQVSVPRPTTRRIGGEPLRDQALLDWCAQLLRDVLGEPAKAATGEPAR
>CP028158.1|AVT33522.1|7598149_7598911_+|hypothetical-protein
MPQAVGLRERVSSMQRARRLASIAVIAVLGTTVLSACRSDSSVAVYLGDKKITEDEVTSVLDDVRSKAASPAPTEPGATPAPGAPEPKTPSRAEVVGTLVMREVCLKLATDKGFKPSEQAPIERIAEATGLPADSRYVRLFSELDACRAGIPVTQPVAPTQEELMDVVARGRVAGVIPPDAKDGEAGQQLDGDVLRRALAMRNTLTEALESSDVTVNPRYRPLEYPVLTFSDSSPALVVPIGQSGSDTVVDAR
>CP028158.1|AVT33523.1|7598984_7599989_+|nucleoside-triphosphate-pyrophosphohydrolase
MTGVAPGPAGRIVLLVTSPRLPAGLLTASAWDVVRGFPVLAGAESELATAVRAAGAEVTVTATPVPDLLGTVASHGTAVWLAGPAGDEALARELGLRLARQPGLAELELMYGSWDPPGARLLDAVEVMDRLASPGGDPWKRAQTHASLAQYLLEECYEAYDAIAANDLVALREELGDVLLQVVLHARLAENLPEEERWSIDDVAGGLVAKMVRRNPHVFAGTEVGGIDEIIENWERIKRAEKPRASVLDGVALSQPALALAAKVLHRVARAGLDLPPAEPPAGADETVRLGATLLETVARARAAGLDAEAALRQATLAYAATVRAAEQDSIPPS
>CP028158.1|AVT35015.1|7600175_7601531_+|cellobiohydrolase
MRRSGRVPARGRTALAVLAVPVLLAGALGSAGPAGATKPPHLMVNPYAGARVYVNPEWSARAAAEPGGGAIAGQPTAVWLDRIAAIEGTDGAMGLRDHLDAAVAQRADLVQVTLYNLPSRDCGRPLPQGELSIDELDRYRTEFVDPTVEILAAPHYAGLRIVVFVEPNSLPNLVVNTSPRHTATWACDQVLARGTYPDGIGYALSRLGALPNVYPYLDISHHGELGWPEDSGPMTALLHQAATSAGSTVANVHGFVANTANYSPLHEEWFQADDVVNGYPVYQSRWVDWNPFVDEVPYARHMRELLVGAGFSARASLLVDTSRNGWGGPNRPTGPAPATGDLNEYVDRSRIDRRTHITNWCNQAGSGLGERPAVDPEPGIDAYVWVKPPGESDGTGVSRDVGQPYEPMCDPNYNPPGGSFRITGALPGGPPFRQWFPAHFRQLLANAWPPL

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Crispr_ID: CP028158_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_15

7758705-7758805

Orphan

Consensus_repeat	Method
GGCGAGCGCGTCAGCCCAGCGGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_15

>merge|CP028158|15|7758705-7758805|CRISPRCasFinder
GGCGAGCGCGTCAACGTGGCGGGCCAGGCGAGCGCGTCAGCCCAGCGGGCTAGACAGCGCCTGAACGCGGCCGGTCCGGCGAGCGCGTCAGCCCGGCGGGC

>CP028158|15|15|7758705-7758805|CRISPRCasFinder
GGCGAGCGCGTCAACGTGGCGGGC	CAGGCGAGCGCGTCAGCCCAGCGGGCTAGACAGCGCCTGAACGCGGCCGGTCC
GGCGAGCGCGTCAGCCCGGCGGGC

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT33643.1\|7765776_7767063_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238536
CP028158.1\|AVT33633.1\|7753571_7754183_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227803
CP028158.1\|AVT33638.1\|7758808_7760851_-\|S9-family-peptidase	unknown	unknown	gnl\|CDD\|224422
CP028158.1\|AVT33640.1\|7763457_7764510_-\|sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
CP028158.1\|AVT33641.1\|7764797_7765070_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223564
CP028158.1\|AVT33645.1\|7767821_7768910_-\|S-(hydroxymethyl)mycothiol-dehydrogenase	unknown	unknown	gnl\|CDD\|132492
CP028158.1\|AVT35038.1\|7761025_7762789_+\|copper-resistance-protein-CopC	unknown	unknown	gnl\|CDD\|377255
CP028158.1\|AVT33634.1\|7754294_7755041_+\|metallophosphoesterase	unknown	unknown	gnl\|CDD\|277347
CP028158.1\|AVT33636.1\|7755834_7756809_+\|TIGR04222-domain-containing-membrane-protein	unknown	unknown	gnl\|CDD\|275063
CP028158.1\|AVT33629.1\|7750293_7750800_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP028158.1\|AVT33631.1\|7751932_7753009_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276938
CP028158.1\|AVT33630.1\|7750878_7751631_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377851
CP028158.1\|AVT33644.1\|7767192_7767822_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293792
CP028158.1\|AVT33632.1\|7753012_7753342_-\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT35037.1\|7758115_7758586_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224759
CP028158.1\|AVT33646.1\|7769458_7770550_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT33639.1\|7762798_7763455_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107
CP028158.1\|AVT33637.1\|7756888_7757974_-\|epoxide-hydrolase	unknown	unknown	gnl\|CDD\|377658
CP028158.1\|AVT33635.1\|7755043_7755682_+\|LysE-family-translocator	unknown	unknown	gnl\|CDD\|224199
CP028158.1\|AVT33642.1\|7765223_7765682_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|341424

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT33643.1\|7765776_7767063_+\|hypothetical-protein	gnl\|CDD\|238536	cd01116, P_permease, Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.	6.518e-132
CP028158.1\|AVT33633.1\|7753571_7754183_-\|hypothetical-protein	gnl\|CDD\|227803	COG5516, COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only].	2.83958e-08
CP028158.1\|AVT33638.1\|7758808_7760851_-\|S9-family-peptidase	gnl\|CDD\|224422	COG1505, COG1505, Serine proteases of the peptidase family S9A [Amino acid transport and metabolism].	0
CP028158.1\|AVT33640.1\|7763457_7764510_-\|sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	7.68246e-48
CP028158.1\|AVT33641.1\|7764797_7765070_+\|hypothetical-protein	gnl\|CDD\|223564	COG0490, COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism].	2.54566e-10
CP028158.1\|AVT33645.1\|7767821_7768910_-\|S-(hydroxymethyl)mycothiol-dehydrogenase	gnl\|CDD\|132492	TIGR03451, S-hydroxymethylmycothiol_dehydrogenase, S-(hydroxymethyl)mycothiol dehydrogenase. Members of this protein family are mycothiol-dependent formaldehyde dehydrogenase (EC 1.2.1.66). This protein is found, so far, only in the Actinobacteria (Mycobacterium sp., Streptomyces sp., Corynebacterium sp., and related species), where mycothione replaces glutathione. [Cellular processes, Detoxification].	0
CP028158.1\|AVT35038.1\|7761025_7762789_+\|copper-resistance-protein-CopC	gnl\|CDD\|377255	pfam04234, CopC, CopC domain. CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm.	1.03748e-21
CP028158.1\|AVT33634.1\|7754294_7755041_+\|metallophosphoesterase	gnl\|CDD\|277347	cd07402, MPP_GpdQ, Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain. GpdQ (glycerophosphodiesterase Q, also known as Rv0805 in Mycobacterium tuberculosis) is a binuclear metallophosphoesterase from Enterobacter aerogenes that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. The GpdQ homolog, Rv0805, has 2',3'-cyclic nucleotide phosphodiesterase activity. GpdQ and Rv0805 belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	2.44608e-60
CP028158.1\|AVT33636.1\|7755834_7756809_+\|TIGR04222-domain-containing-membrane-protein	gnl\|CDD\|275063	TIGR04222, integral_membrane_protein, TIGR04222 domain. The majority of the proteins with a domain as described by this model have an extreme C-terminal sequence that is consists of extremely low-complexity sequence, rich in Ser or in Gly interspersed with Cys. That C-terminal region resembles ribosomal natural product precursors, although there is no evidence that C-terminal regions of these proteins undergo any modification or have any such function.	2.23326e-26
CP028158.1\|AVT33629.1\|7750293_7750800_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.12378e-13
CP028158.1\|AVT33631.1\|7751932_7753009_+\|hypothetical-protein	gnl\|CDD\|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	4.30345e-26
CP028158.1\|AVT33630.1\|7750878_7751631_-\|hypothetical-protein	gnl\|CDD\|377851	pfam07501, G5, G5 domain. This domain is found in a wide range of extracellular proteins. It is found tandemly repeated in up to 8 copies. It is found in the N-terminus of peptidases belonging to the M26 family which cleave human IgA. The domain is also found in proteins involved in metabolism of bacterial cell walls suggesting this domain may have an adhesive function.	1.0122e-25
CP028158.1\|AVT33644.1\|7767192_7767822_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	4.3037e-52
CP028158.1\|AVT35037.1\|7758115_7758586_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.25749e-16
CP028158.1\|AVT33639.1\|7762798_7763455_-\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	7.98224e-68
CP028158.1\|AVT33637.1\|7756888_7757974_-\|epoxide-hydrolase	gnl\|CDD\|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	1.30018e-60
CP028158.1\|AVT33635.1\|7755043_7755682_+\|LysE-family-translocator	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	8.81105e-33
CP028158.1\|AVT33642.1\|7765223_7765682_+\|histidine-kinase	gnl\|CDD\|341424	cd17788, CBS_pair_bac, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	5.1214e-44

>CP028158.1|AVT35037.1|7758115_7758586_+|MarR-family-transcriptional-regulator
MESPTGESPPARLAGLPSWLLTQTARHAHRLVTEGFAEIGSRGYHYRLLLTLDEVGPTSQADLGRRSGIHLSDVVAAVNDLADRQLVERSPDPTDRRRNVITLTPAGRRQLRRLDQRLTRIQDDLLAPLAPAERDQLTRLLTRLLDHHRGSPAADD
>CP028158.1|AVT33637.1|7756888_7757974_-|epoxide-hydrolase
MIKPFRIEIPEADLTDLAERLRRTRWPEQLPEAGWDYGIPLERVRELADHWRTGYDWRRQEAALNELPQYTTEIDGQNVHFLHLRAADPDALPLLLTHGWPGSVVEFLDVLGPLAEDFHLVVPSIPGYGFSGPTRERGWDVHRVARAWAELMRRLGYRRYGAHGGDWGSAISRALGEYAPENVVGVHLTYLPTPPPPGWTGEAELSESDRERLARIRQYVAQRPGYMVLQSTRPQTPAYALTDSPVGQLAWIAEKFTEWTDPSSTIPVDRLLTNVMLYWLTGTAGSSARLHRESPIGPQSCPVPVGVAVFAHDITRSIRSLAERAYPIVRWSEFDRGGHFAALEVPELLVDDVRAFFWGLR
>CP028158.1|AVT33636.1|7755834_7756809_+|TIGR04222-domain-containing-membrane-protein
MTLDPSNLTWGISASAFLAGYLLLAVVVVGYATARRRQILAGPESVRTSALTADQVGYLNGGERLAVYTALAGLRNAGAIAIGPAPDRYLVVAGDRPVGASGLAAAVHRFAGQRRRPRELTWDSGVAMELSRLRTGLEQAGLMPGAETRRALRGSTWLLGGVLLLGVLRLLAEVSTGEPWLPLVLVLVGLGIATVLLGRRPPVRTRAGDWALGNLRTAHAHLSPAQQPAWNTYGPTGAAMSVALFGPAAFWAADPEFAAEAGIQQRLGVATAGGSSGDSGGSGGFVCSVGGFGSDSGGWHGGGSDSAGSGCGGGGGCGGGGGGS
>CP028158.1|AVT33635.1|7755043_7755682_+|LysE-family-translocator
MRGIAVLGFLAAVAPITATPGTSLALVVSRVAAGGRRQGWWVILGTLSGLYVHALLAAVGLAALVLRSSQAFLLVKLLGAGYLVGLGLWLIRSASRRRPSTVDEPAAPPARRLPWRGHHPYLQGFLGNVLNPKAAAVYLTLAPQFLDVRGPVLVPMLVLGTAHALLAGCWLAGWTAISGAAARLLRTVRVRRALDRATGAILVGLGVRTAVS
>CP028158.1|AVT33634.1|7754294_7755041_+|metallophosphoesterase
MLVIAHLSDTHLDSDPRSADRTARVMDYLHALPRPVDAILVTGDIADHGEVAEYEIAAKLLASPLPVLVCPGNHDARDAYRKGLLGDPRGGTGPINRRHDVAGAVFLLADSSVPGRDDGHLDAETMGWLADQLGSTPAGAPVFVAFHHPPVALHHPVADPIRLLPAEPLAELLAGHPQVVAVLTGHFHTAAASTFAGRPLRIAPGVASTLRLPWEGDGPLLDLTQPPGVAFHVYDDAGLLTTHYRVVG
>CP028158.1|AVT33633.1|7753571_7754183_-|hypothetical-protein
MSQQLALALAGTIRHDGNGGVADDLADVSGLTGWLGEQAEPLREYAGSLDPDGELADERLRLDVVGVRRAARTLFARAVHPGPPSRADSAALLPAQEAVDQLNRAAGLWPVRPVLSWPDQAEPTLAWSGEPADARVRLVAGLARATIEFLTSPARDRLAACPAPRCVRYFVREHPRQEWCKASCGNRARVHRHYRRHAADRTD
>CP028158.1|AVT33632.1|7753012_7753342_-|hypothetical-protein
MLTAAAIGVALVAPPVPALAAPGDQRWSCGSVPAGWVVLAYGGICDPNTRASYLFVQQAEGMPAGSSLTVCQFSPIPGGWRIVYGPVHLSACVVNWGSSSPNAYIISNS
>CP028158.1|AVT33631.1|7751932_7753009_+|hypothetical-protein
MDRHLRLPLRWGSGAVREESGTFGALLRGYRTRAGMTQVALATRAGVGVRTVRDLEHDRVRQPQRRVLNRLAAALDLSAAEQARLGSTTTAGRPGERDRSLRIDVLGPLRIRHGDRPVDVGPPKHQLLLGLLAVQPDQPVPVCDIVDVLWDRPPRSCRGLVQTYLTRVRRLVRAGYAGSATAPVIVRDRHGYRLALPADRVDAGRFRCLAERAARAHRRGQLDRAVELFSAGLACWRGPLLAGAGTGLLRHPAATALSRHRLDCVLTLADLAFATSAAGRATTPLAEVAEVEQLHEGLHARLMLALAGTGQQASALRLFGRLRARLADELGVLPGAELRAAHLRVLRQQVPGTDGRPA
>CP028158.1|AVT33630.1|7750878_7751631_-|hypothetical-protein
MTYQPHEPGAYPHTPQQPVYQPPGPAYPARPRPGRLGRLGPGQKAALFVGGPVLSLLLCCGGLAAIGNGADPDAGSANTSSAADAPAPAASSGSPSSPVTEASQVPSPAPTSAGPTTERRRVTETRSIPFGQRTMQDSSLAKGKREVRTAGVKGAKTLTYEVTYVNGVQTAKKLVKEVVTRKPVTQVVAVGTKETRRCDPNYSGCVPIASDVDCAGGGGNGPKYVSGPVRVIGDDIYDLDRDGDGYGCDD
>CP028158.1|AVT33629.1|7750293_7750800_-|GNAT-family-N-acetyltransferase
MRIRPARRQDLPGLRDIERAAGRSFRDVGMPEVADDEPPSVEELARHQRAGLAWVAVDADDVPVGYLVAEPVDGNLHVEQVSVHPRAARRGVGRQLLEHLAAHARAAGVPALTLTTFTDVPWNAPYYARCGFVVLDEPELTPGLVAIRAREAAHGLDRWPRTCMRRDL
>CP028158.1|AVT33638.1|7758808_7760851_-|S9-family-peptidase
MSPDLDDEFRWLEALSGPEVTAWLRARNAETRDALADDPAFAALEAELRQVLDAADRVPFVHWDGTYLYNLWKDEAHPRGLWRRTTLDEYRRAEPNWEVLLDVDALAAAEGEPWTWQGAVVARPGYRRCLLRLARGGSDASVVREFDLTTRTFVPDGFCLPEAKSDVGWIDADHIYVGTDFGPGSLTASGYPRIVKRWRRGTPLAEATVVYQGRDDDVSVYAVHDPTPGFVRDFLGRRLDFFRREEFLRTVDGELVRIDVPEDAGTDVHREWLLITLRSDWTVADRTYAAGTILVTRLDRFLAGERDLTVVFAPGPESAPGRHAWTRGHLILNTLVDVRSRTEVLSPGEDGWRRRPLLETAAAPGDERHVVIVDTNPEQSDEYLLASTGFLAPTALHYGTVDGSAETLKRDPAFFDPAGMTVRQLHARSADGTRVPYFLVGPAGESTGPTLLTGYGGFEVAWTPSYSGIIGRGWLARGGRYVVANIRGGGEYGPRWHRAALRENRLRAYEDFAAVATDLVDRGVTVPARLGIEGGSNGGLLMGVMLTRFPELFGAVVARVPLFDMRRYHLLLAGASWMAEYGDPDDEADWAFLREYSPYQNVRPGRAYPPVLFVTSSRDDRVHPGHARKMAARMRSYGYDVSYYENVEGGHGAAADNAQLAFKWALMLRFLWRRLTDPPH
>CP028158.1|AVT35038.1|7761025_7762789_+|copper-resistance-protein-CopC
MVALGRAVLAVLLLGAVAVLLAPAKPAAAHAAVVGTVPQQQAVLGFSPTEVTITFSEPVALVPGRAQVLAPDGKRINDGDASVRDATLRIPIRVADRPLGSYLVSYRVISADSHPVAGSYTFAVGAASATPPEPADETVRPDVQVAMPATRYLGYAGLVLLIGPTLLLGLLWPRRLPRRGAIRLVRAGVALVTVGALAGFWTQAPYTSGAGLLDVSAAELWQLLGSDFGLALAARLGILALVAALLPPVLAGRAGRARVGVLVALGLAGLATWPLAGHAAASPTPLASGIAAVVHLAAMSVWLGGLVTLVCFPLRSAHPRVLAVLLPVWSRWAGIAVLWLVAGGVVQAVIEIGAPGALLGTGYGRLVLAKVALLALLLGAAGYARRLVRRRATAGLATAPATARTGLLVSAGAVPPAAAPARPPAPPGDSAAAAVAGRRRLRRTVGLEVLVGLVVLGVSAVLVQTTPGRNAGIEAEIAASDTFAQTLTSPLYTLQFDIYPVQLGPNNTVHAYVYTPQGKPLPAVEWTLTAGLPAQGVEPTDTPMLGIEPHHAVGAVSFPVPGDWELRFTVRTSEIDQATVRTVVRVR
>CP028158.1|AVT33639.1|7762798_7763455_-|DNA-binding-response-regulator
MSATVTRVLLADDHALVRRGLRLILDAEPDLRVVAEAADGAEAVEAVRRTEIDLVILDIAMPRMTGLQAAREISRRAPGVRILMLSMHDNEQYFFEALRAGASGYVLKSVADRDLLEACRAAMRGEPFLYPGAITALIRDYLHRARQGEKLPESILTPREEEIIKLIAEGNSAKQIAEALVISVKTVDRHRANILAKLGMRDRIDLTRYAIRAGLVEP
>CP028158.1|AVT33640.1|7763457_7764510_-|sensor-histidine-kinase
MTDTADRAAAPGPDSPGRSGASGRPGRRAPAQALFRRLFLLNGLVFTVGTLVLALSPATVSSPVLLAEIPVLTIGLALILAANALLLRASLAPLDALTTLMRRVDLLRTGDRLVDAGNGDLTNLIETFNAMLDRLEAERSASSAHALAAQEGERQRIARELHDEIGQSLTVVLLGLKRAVDRAPAELREELHAVQETLRESLDDVGRVARRLRPDVLEDLGLLSAMNALATEFSQVSGVPVVRRSTPDLPALSAEKELVIYRIAQESLTNVARHARAGRVELSLRAEAGTVVLRVVDDGLGEIAREGAGIRGMRERALLIGARLTITATPGSGTEIRLAVPADDSAEREA
>CP028158.1|AVT33641.1|7764797_7765070_+|hypothetical-protein
MDITRTTVPGVGVVHHFLTRGGQRFGVLLDQAGLRSLLLYGPDDPDVPVDRIALEHDEADQIAEVLHSAPIADRLASLERRLAELHGGSA
>CP028158.1|AVT33642.1|7765223_7765682_+|histidine-kinase
MQAQQIAAVVPTVTVRDSVARAVRLMALRRLPGMIVVDDRGRPKTVLPGTQVLRMAVPRAYREDPMLARTIDEARADLFWEELDNLTVGDCLFREPDRVTTVGLDGTLLEVAALMARQRSPLVAVVDGAGVLVGAITLDRVLAEFAVADSDT
>CP028158.1|AVT33643.1|7765776_7767063_+|hypothetical-protein
MSAVAALVIFVVAFFFIATEKVDKVKVVLIAAAAMLVFGFAPGAEVYFSEHEGIDWKVIFLLLGMMIIVGVLKQTGLFDYLAIWAAKRSSGRPYRLMVMLMLITAIASPFLDNVTTIMLVAPVTVVVCNRLHIPAQPYLIAEILASNIGGAATLIGDPPNIIIGSRAGLTFTDFLVHMAPAVVVIFAVFVLFTRVLFRKSFKYNPEHVEAVLALQERRAITDVRLLVRCLVVLGLVVVAFGLHSVLHVDPSVVAMVGAGVMLLVSKMDVSDVLGEVEWPTLVFFMGLFVMVAGLVHTGVITTFGEWVIEQVDGNFFGAATALLFGSAVLGAFFDNIPYVATMAPVVEGLVATAPDPQTGQALWWAFAFGADFGGNGTAVAASANVVAIGIAARTGHRISFWQFTRYGIIVTIMSTVLAWIYVWLRYFM
>CP028158.1|AVT33644.1|7767192_7767822_-|MBL-fold-metallo-hydrolase
MAARIDHAVTSGTFSLDGQTFDVENNVWVVGDDAECVVIDAPHDVDAILAAVGDRRVRAILATHAHDDHVRVAPALAEATGAQVLLHPADRVLWDMVHPEVPPGGELADGQSIEVAGTTLEVRHTPGHSPGACSLYAPSLGAVFTGDTLFQGGPGATGRSYSDFGTIVESIRRRLLSLPPETVVHTGHGASTTIGAEAPHLDEWLARGH
>CP028158.1|AVT33645.1|7767821_7768910_-|S-(hydroxymethyl)mycothiol-dehydrogenase
MSQEVRGVIARAKGAPVEVATIVVPDPGPGEAVVRVQACGVCHTDLHYREGGINDDFPFLLGHEAAGIVEQVGAGVTDVEPGDFVVLNWRAVCGNCRACRRGKPWYCFATHNASQKMTLTDGTVLSPALGIGAFVEKTLVHAGQCTKVDPAARPAAVGLLGCGVMAGLGAAVNTGGVTRGDSVAVIGCGGVGDGAVAGAALAGATTIIAVDTDPRKLDWARGFGATHTVDARQTDPVEAIRELTGGHGADVVIEAVGRPETWKQAFYARDLAGTVVLVGVPTPEMKVPELPLLDVFGRGGALKSSWYGDCLPDRDFPMLTSLYLQGRLDLDAFVTEEIALDQVEDAFGKMHHGDVLRSVVIF
>CP028158.1|AVT33646.1|7769458_7770550_+|hypothetical-protein
MAGPYEITVRGPLGRGLARTLEFAEGLSVISHPAWREITANGLEPATVGADATLPDLSVTPPMTHLGPADTAVELQLDSPGGATTVRVTPAHMALQRLGGGSRGEWSLQPLRLDTETIGEGELLVRLPRAVDARLIVRSGGRELQTVPSGETYGQPMARFRLAAIADTVGAHGLAQLDVRFDGQDFPAARCVPRRLASAVHLEDDRLVLVDGVRAEGLTAALYQVYAPWEPPYLARLSADLVSDPLPTRVITAGPLVALLRIEDPWLPSDWPEWPGRDNSFDLAELTWQPTGQDPAGEAVSAYLAGAAALPDLPDIAPLLFDLYPRGRPSYPRCHGQHPGRRAAPAPASRRRAGRAHQAPRLG

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Crispr_ID: CP028158_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_16

7862690-7862770

Orphan

Consensus_repeat	Method
CCGGGAAGCGCGCGGAACTGTCGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028158_16

>merge|CP028158|16|7862690-7862770|CRISPRCasFinder
CCGGGAAGCGCGCGGAACTGTCGCCGCCACGCGACGGGGAGCAACTGCGGAAATCCGCCGGGAAGCGTGCGGAACTGTCGC

>CP028158|16|16|7862690-7862770|CRISPRCasFinder
CCGGGAAGCGCGCGGAACTGTCGC	CGCCACGCGACGGGGAGCAACTGCGGAAATCCG
CCGGGAAGCGTGCGGAACTGTCGC

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT35046.1\|7851744_7852527_+\|shikimate-dehydrogenase	unknown	unknown	gnl\|CDD\|223247
CP028158.1\|AVT33694.1\|7855133_7856192_+\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT35048.1\|7872308_7873394_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|223745
CP028158.1\|AVT33698.1\|7859576_7860284_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|319852
CP028158.1\|AVT33697.1\|7858333_7859587_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225688
CP028158.1\|AVT33693.1\|7853748_7855137_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|212516
CP028158.1\|AVT33701.1\|7863080_7864265_+\|3-amino-5-hydroxybenzoic-acid-synthase	unknown	unknown	gnl\|CDD\|366433
CP028158.1\|AVT33692.1\|7852865_7854077_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214792
CP028158.1\|AVT33706.1\|7868822_7869782_+\|epimerase	unknown	unknown	gnl\|CDD\|187575
CP028158.1\|AVT33696.1\|7857087_7858341_+\|carboxylate--amine-ligase	unknown	unknown	gnl\|CDD\|235010
CP028158.1\|AVT33702.1\|7864290_7865028_+\|phosphoglycolate-phosphatase	unknown	unknown	gnl\|CDD\|130521
CP028158.1\|AVT33705.1\|7867990_7868764_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368580
CP028158.1\|AVT33695.1\|7856188_7857091_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366736
CP028158.1\|AVT33703.1\|7865071_7866454_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341228
CP028158.1\|AVT33707.1\|7870776_7872249_+\|carboxylesterase	unknown	unknown	gnl\|CDD\|225181
CP028158.1\|AVT35047.1\|7869778_7870600_-\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|213873
CP028158.1\|AVT33700.1\|7861424_7862660_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340863
CP028158.1\|AVT33699.1\|7860220_7861417_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377314
CP028158.1\|AVT33708.1\|7873501_7873780_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|183533
CP028158.1\|AVT33704.1\|7866483_7867692_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT35046.1\|7851744_7852527_+\|shikimate-dehydrogenase	gnl\|CDD\|223247	COG0169, AroE, Shikimate 5-dehydrogenase [Amino acid transport and metabolism].	3.67907e-63
CP028158.1\|AVT33692.1\|7852865_7854077_+\|hypothetical-protein	gnl\|CDD\|214792	smart00729, Elp3, Elongator protein 3, MiaB family, Radical SAM. This superfamily contains MoaA, NifB, PqqE, coproporphyrinogen III oxidase, biotin synthase and MiaB families, and includes a representative in the eukaryotic elongator subunit, Elp-3. Some members of the family are methyltransferases.	1.28447e-15
CP028158.1\|AVT35048.1\|7872308_7873394_-\|oxidoreductase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	1.75759e-33
CP028158.1\|AVT33698.1\|7859576_7860284_+\|hypothetical-protein	gnl\|CDD\|319852	cd16415, HAD_dREG-2_like, uncharacterized family of the haloacid dehalogenase-like superfamily, similar to uncharacterized Drosophila melanogaster rhythmically expressed gene 2 protein and human haloacid dehalogenase-like hydrolase domain-containing protein 3. The haloacid dehalogenase-like (HAD) hydrolases are a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members include 2-L-haloalkanoic acid dehalogenase (C-Cl bond hydrolysis), azetidine hydrolase (C-N bond hydrolysis); phosphonoacetaldehyde hydrolase (C-P bond hydrolysis), phosphoserine phosphatase and phosphomannomutase (CO-P bond hydrolysis), P-type ATPases (PO-P bond hydrolysis) and many others. Members are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	5.64705e-34
CP028158.1\|AVT33697.1\|7858333_7859587_+\|hypothetical-protein	gnl\|CDD\|225688	COG3146, COG3146, Uncharacterized protein conserved in bacteria [Function unknown].	1.70535e-06
CP028158.1\|AVT33693.1\|7853748_7855137_+\|hypothetical-protein	gnl\|CDD\|212516	cd09990, Agmatinase-like, Agmatinase-like family. Agmatinase subfamily currently includes metalloenzymes such as agmatinase, guanidinobutyrase, guanidopropionase, formimidoylglutamase and proclavaminate amidinohydrolase. Agmatinase (agmatine ureohydrolase; SpeB; EC=3.5.3.11) is the key enzyme in the synthesis of polyamine putrescine; it catalyzes hydrolysis of agmatine to yield putrescine and urea. This enzyme has been found in bacteria, archaea and eukaryotes, requiring divalent Mn and sometimes Zn, Co or Ca for activity. In mammals, the highest level of agmatinase mRNA was found in liver and kidney. However, catabolism of agmatine via agmatinase apparently is a not major path; it is mostly catabolized via diamine oxidase. Agmatinase has been shown to be down-regulated in tumor renal cells. Guanidinobutyrase (Gbh, EC=3.5.3.7) catalyzes hydrolysis of 4-guanidinobutanoate to yield 4-aminobutanoate and urea in arginine degradation pathway. Activity has been shown for purified enzyme from Arthrobacter sp. KUJ 8602. Additionally, guanidinobutyrase is able to hydrolyze D-arginine, 3-guanidinopropionate, 5-guanidinovaleriate and L-arginine with much less affinity, having divalent Zn ions for catalysis. Proclavaminate amidinohydrolase (Pah, EC 3.5.3.22) hydrolyzes amidinoproclavaminate to yield proclavaminate and urea in clavulanic acid biosynthesis. Activity has been shown for purified enzyme from Streptomyces clavuligerus. Clavulanic acid is the effective inhibitor of beta-lactamases. This acid is used in combination with the penicillin amoxicillin to prevent antibiotic's beta-lactam rings from hydrolysis, thus keeping the antibiotics biologically active.	4.15456e-59
CP028158.1\|AVT33701.1\|7863080_7864265_+\|3-amino-5-hydroxybenzoic-acid-synthase	gnl\|CDD\|366433	pfam01041, DegT_DnrJ_EryC1, DegT/DnrJ/EryC1/StrS aminotransferase family. The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.	1.71369e-127
CP028158.1\|AVT33704.1\|7866483_7867692_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	7.9527e-69
CP028158.1\|AVT33706.1\|7868822_7869782_+\|epimerase	gnl\|CDD\|187575	cd05265, SDR_a1, atypical (a) SDRs, subgroup 1. Atypical SDRs in this subgroup are poorly defined and have been identified putatively as isoflavones reductase, sugar dehydratase, mRNA binding protein etc. Atypical SDRs are distinct from classical SDRs. Members of this subgroup retain the canonical active site triad (though not the upstream Asn found in most SDRs) but have an unusual putative glycine-rich NAD(P)-binding motif, GGXXXXG, in the usual location. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	9.87e-40
CP028158.1\|AVT33696.1\|7857087_7858341_+\|carboxylate--amine-ligase	gnl\|CDD\|235010	PRK02186, PRK02186, argininosuccinate lyase; Provisional.	5.73524e-32
CP028158.1\|AVT33702.1\|7864290_7865028_+\|phosphoglycolate-phosphatase	gnl\|CDD\|130521	TIGR01454, AHBA_synth_RP, 3-amino-5-hydroxybenoic acid synthesis related protein. The enzymes in this equivalog are all located in the operons for the biosynthesis of 3-amino-5-hydroxybenoic acid (AHBA), which is a precursor of several antibiotics including ansatrienin, naphthomycin, rifamycin and mitomycin. The role that this enzyme plays in this biosynthesis has not been elucidated. This enzyme is a member of the Haloacid dehalogenase superfamily (pfam00702) of aspartate-nucleophile hydrolases. This enzyme is closely related to phosphoglycolate phosphatase (TIGR01449), but it is unclear what purpose a PGPase or PGPase-like activity would serve in these biosyntheses. This model is limited to the Gram positive Actinobacteria. The most closely related enzyme below the noise cutoff is IndB which is involved in the biosynthesis of Indigoidine in Pectobacterium (Erwinia) chrysanthemi, a gamma proteobacter. This enzyme is similarly related to PGP. In this case, too it is unclear what role would be be played by a PGPase activity.	2.12391e-93
CP028158.1\|AVT33705.1\|7867990_7868764_+\|hypothetical-protein	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	3.96368e-28
CP028158.1\|AVT33695.1\|7856188_7857091_+\|hypothetical-protein	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	7.49541e-10
CP028158.1\|AVT33703.1\|7865071_7866454_+\|hypothetical-protein	gnl\|CDD\|341228	cd04433, AFD_class_I, Adenylate forming domain, Class I, also known as the ANL superfamily. This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.	4.63187e-62
CP028158.1\|AVT33707.1\|7870776_7872249_+\|carboxylesterase	gnl\|CDD\|225181	COG2272, PnbA, Carboxylesterase type B [Lipid metabolism].	8.91836e-104
CP028158.1\|AVT33708.1\|7873501_7873780_-\|hypothetical-protein	gnl\|CDD\|183533	PRK12449, PRK12449, acyl carrier protein; Provisional.	0.000201525
CP028158.1\|AVT33700.1\|7861424_7862660_+\|hypothetical-protein	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.20976e-44
CP028158.1\|AVT33699.1\|7860220_7861417_+\|hypothetical-protein	gnl\|CDD\|377314	pfam04339, FemAB_like, Peptidogalycan biosysnthesis/recognition. FemAB_like is a family of both baterial and Viridiplantae proteins with responsibility for building interpeptide bridges in peptidoglycan. Such a function is feasible for bacteria but less likely for the plant members of this family. Perhaps the plant-members are using homologous proteins to recognize bacterial peptidoglcans as part of their innate immune system.	2.14038e-20
CP028158.1\|AVT35047.1\|7869778_7870600_-\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|213873	TIGR03856, F420_MSMEG_2906, probable F420-dependent oxidoreductase, MSMEG_2906 family. This model describes a small family of enzymes in the bacterial luciferase-like monooxygenase family, which includes F420-dependent enzymes such as N5,N10-methylenetetrahydromethanopterin reductase as well as FMN-dependent enzymes. All members of this family are from species that produce coenzyme F420; SIMBAL analysis suggests that members of this family bind F420 rather than FMN. [Unknown function, Enzymes of unknown specificity].	3.39885e-139

>CP028158.1|AVT33700.1|7861424_7862660_+|hypothetical-protein
MTSSAGGVYAALAERRFRSYWISQLPSLLGDALVPVTLSFAVLGGGGSAADLGLLLAAQLLPQILLLGPGGVLADRVSRVRLMVAADVLRGLAQLTTAALLLTNQTWLSMVLPQLLLGAAAAVFRPAAYGLIPSLVSKPRLHSANALVTASTTVTAMVGPLIAALLLAVMPAGLVVAVDGLSYLVSAFALVVFRLGGRAPDRSGHQSFLRDARAGLTEIRTRPWIWIGLICTAVSLTLVTSPFLVLGPLVAERSFGGASTWAVWLVAFSIGELVGSYLAARVRPERPALWASAALILLAIPPLLLALPASAPAITAAEAGAGLAIGWHAVLWSTAIQSDVPDEAMSKVGAMVTFGSFALQPLGLAVTGPFSEVVGVETVFWIASVSALLSTGVLVASRSIRRFVVVPASSA
>CP028158.1|AVT33699.1|7860220_7861417_+|hypothetical-protein
MAGAVPRRAAPVHCDRSGQGVTVTDPPRVTVAGSLSEVEPARWASLATGWPVELSHAWLRAEEGRTAAAQWYLLAWRPDGRLLGALAAYLFDGPITHTAYPVQSVLRGTSQDLDPALHPSLVCVAPGSYRPGLLSDRTLDPESTMRVREALLTAFEEHARDLGCAAISVMHVSGGDTGLAGLLAGRGYAKALVSADAVLRVPAGSFPDYLATLPPDRRRKVRRERRTFLDSGVTVHAGGAELLTESLAPLLVDHYRRYGHPADERGVLDRFHRVRRQGELRVFLARAGDEIAGFSAFFTDGADRLVGRLYAARSAGAFEYFNLVYYEPITAAARDGIRAIHYGSESFDAKVFRGCTLRPLYGHFGSVAGHAGTLSRMAYERCAAERTRLRDFVPYLAE
>CP028158.1|AVT33698.1|7859576_7860284_+|hypothetical-protein
MTRDAEAYLFDGAGTLFDCHPTLAEYIAQTSRSFGFTIEPADAGQALATVGGAYGWPDDTDDVAARKAGWLAFFDRVLLTCGARHHRAEHAEVVANFVLDPGSYLRYDDALPILRAVRDGGLKLGLVSNFDRWLRDVLRKLDLLDYFDVVTISTEVGVAKPDPRIFRAALGQLGVPAGRSVFVGDSLLADVAGAQAAGMIPVLLDRDGTHPDHPGWRVRSLDELHRCIATGPGRG
>CP028158.1|AVT33697.1|7858333_7859587_+|hypothetical-protein
MTDRIATSLADIEAAVWDRAGCSSSVYLTHAWLCSVEGRISPTQFYLLSGPDSRPSGRLSCYLLPEPAGNYATFDPVETLLVADSRARVTGYGAEGDADAYDAALAEVARNRATLYPALVCAVPNGYLAGIDRARTGGPDPDRAAPDRADPDGTDPDGAVLTHLLDRFEALARSVGARTAAVLYVPDGDLALARQLRVRGYVEAVAGANSVLEVPAGTFEDYLGGLRGIRARKEVERFRGYGLTVEICDSSVLDERLAELQLQHYRQYGLRGSLDHVLRSFRETRRHLGDKLRVIRVHRRETIVGFHSGFRYGRSLFSRYGAFDRDLLGRETFAHFNLQYYEMVRLAQAEGVREIHYGLGSYPTKVRRGCRLDALRTFVRPMATGPATSALATCWRLLGRANEREIAAVTGGVQHDT
>CP028158.1|AVT33696.1|7857087_7858341_+|carboxylate--amine-ligase
MRHVLLVGGGSPLPQRIRSLRDPVRTSVMVRNRNFGDVPEPGENVRVLGMRDEAPAEEWVRTAAAIHECDPFDGIGAFAEDDQDKAAAIAAKLGLRFHAVGTVESVYDKLRMRERLAAAGVETVPAVAVESADDVRAFARQVGYPVIVKPRTGTGSAGVVAVRAEPDVAEAVDWAVGTGVHGNRLVMAEPLLTGRELTVEAFSEDGVHRLVGTTQKSRSPRHYVDVGHWMPATLRPDETDLVWSHVARMLDALGIGYGPTHTELILTGAGPRVVETHIRCAGDHLPVLAQDVRGVDLYELTARQVAGERVLPVLDQQLANPASGGAAVWYAAPAARGVLVSVDNLAEAQALEGVRAIEVLVPQGSDFDGIRVSDSFGRVVGCRAVGPDGERAARTAREALAALVFAVRCTVTDNDFD
>CP028158.1|AVT33695.1|7856188_7857091_+|hypothetical-protein
MMRTTDPPARIEEFAASGGYTDLRPLGQGLEFLAFGATAADGSPVVLRTAVGARIQSNANDPYVDTRQLLRWEQSVTVHLTRLGFPVAAPRELVLGEVDVLISEYLPDDGRGADQQQLGTLLRRLHDLPPPLAEPVAAEGTTSAELLPRRIVRRWRELAALVPDLPTAPDTERLAAELARPRPGALVHLDVRAANLRCTAGRVRGLIDWSNAMVADPVLELARLAEFARLPGNGLDLDAVLAGYGCSGLPDSPTTSIYRLDAAVMLAVVFRCEAPDPQLGSRAVDRLRELRAQLDRELSR
>CP028158.1|AVT33694.1|7855133_7856192_+|hypothetical-protein
MTIVRFASTDQYLDCAELVHGEDTEAAARALAERAVPLVQRAGSVVFRLGRLRLGIEDSRALSRAICEALRRALVAGGAPASMRLEHDRAQSTHVPSGYPTRTLLPHHDGQHCSYLTPSTRDDPSWLPEWREFGRSGYTTTPAHKMYQGVFIADPGEALSVTTYYDWLDLLTTVYAERHRRPAAEVPLGAVAEWLGRNLRAALDRQAKHGSPYPTIGAMLGVEEPMWHGLSFHHAEAELSGEDRERYPMSGPLARACPCGDCVGDTARLFCHQTLLATGRDWRQFRARWEVCAPSERFDLLFGHNLTMLHGGLAGGGHRVIEPMCLVVDEPSGPEYEDWLAASWRRRLPVGE
>CP028158.1|AVT33693.1|7853748_7855137_+|hypothetical-protein
MGWTRRPRCPTGKPWNGCGTTAPCSGCSTCTTSSPIRSCRTSPGCGTGYSTGISPTGAKTAHRCTGHRTSPQSGAGNCSPKRSTSHTESCGRASRWPSGERSRAVDHLPDFAELAARATPADFRDDPLPGWAGLGTLFGAPAARLDELGQVDGWAVAAVPFDGTASSRPGAAEGPRALRTASVVFANSLASLGTWEMLDTRTGEAFRYVAPQVVDVGDLHVYPTDTFRTYQAVAAESRSLCARAGRVIFLNGDHSTTFATFSGFRAAQLDRAAGRRIGFVNIDHHFDFGRWSALHGALYHGSNSRRISELPGMRPEDIAFVGVGDTTRFDQFRSLVEQGFQVVPAARIMRTGADAALRPVVERLAAVCDAVYVSLDIDVLDTAAVTGTGHVTMGGLQVAHLLDVYEVLRELPIGALDVAEIAPRYDPTGATAQVVARLLFEFLFRTGRHDPGLPHWRFDEGG
>CP028158.1|AVT33692.1|7852865_7854077_+|hypothetical-protein
MPLWVAHLTALIRVAGLDSAFCDLSRRPADAQECADHVQEASDPGDLILMSPLAQNMGLALETAALLRTAGRRVVIGGNMAPLVPAGAVDLVHRGQLDPTLVGKLVRLATSGGGEIVNPPGRGRSANMIDWAPDYRHLDGYRGRVPLLRLNASHGCLYSCSFCGDAWTNQLVLVDRAALAAEVDELTKRFPDTRLVYIGDKTFGQSKEATRNLVEVFRDRPGFQFVVQTHVMQVRPWVIDAMRELGVVAVELGFESGDSQLLARLNKLSRGLDDYAEKIRMLDDAGMKIVLNVLGGLDEETEVSHRETVEWLWDNRSMLWLFNLYNFVPYPLVPDFPRLRDRIFDWDFANWREDCPPVYRPQNLTPERSWELFTEKVDVAHRIVREGIEMAFRGAEQGCGSPA
>CP028158.1|AVT35046.1|7851744_7852527_+|shikimate-dehydrogenase
MSGTTRLYAVLGDPVTQVKAPGLVNPLFAAEGVDAVLVPVHVRPDRLGEVVAGLTAMTNVDGLLVTVPHKVAVCRYADRLAPAALIAGSANALRREPDGGWLADNFDGVGFVRGLRAAGHDPAGRYVALVGAGGAGGAIAAALADAGVAQLRISDTDQVRRDDLVSRSNRRRPGLAVGVDEHSGSDVHLAVNATPLGLRDDDPLPFSPGSLPRDCVVADIIMVPAQTRLLREAEAAGRPVHPGIHMLRFQLDSYRAFFGF
>CP028158.1|AVT33701.1|7863080_7864265_+|3-amino-5-hydroxybenzoic-acid-synthase
MDVVAISRQSLDLPRWPQFDDREKAALLRALEQSGWWRFDGHEVSEFEKEFAGYHGARRALAVTSGTHALELALQVVGVGPGTEVIVPAFTFISSSQAAQRLGAVAVPVDVDPVTYCMDVPAAEAAITERTRAIMPVHMAGLLAGIDALGKLSDDSGVPLVHDAAHAHGAQWRGLRLGELASIATYSFQNGKLMTAGEGGAVTFSDAQEYEAAFLRHSCGRPRADRAYRHEVSGSNFRMNEFSASVLRVQLARLDEQIDIRERRWPVLADLLARIPGVLPQGSDEGCTRNPHYMAMFRVPGITAERRQTLVDEMVARGVPAFAAFRAIYRTSAFWEAAAPAEDVESIARRCPNVEAITNDCIWLHHRALLGTEEQMSAIAEVVSDVVGNTVASS
>CP028158.1|AVT33702.1|7864290_7865028_+|phosphoglycolate-phosphatase
MSEETVPCHSSAARPGLVTGTALRGVVFDLDGVLVNSFDVMRLAFDHAFREVVGDGEAPFEAYRQHLGGYFPDIMRLMGLPPELEGPFVRESYRLAHQINLYDGVGEMLVELRERGIRCAVATGKSGPRARSLLDGLGVLEIFDCVVGSDEVDRPKPAPDIVRRALYLMDVDRDAAVMIGDAVFDVMSARAAGVGAVAALWGECDREVLLAAGPDASVENPAEFLALLRARDGAAGSPRRDDRAT
>CP028158.1|AVT33703.1|7865071_7866454_+|hypothetical-protein
MVVTIERILVDCREARLVVGDAAWSSEELLRCGGRLAEEISSRFDGLRLLTVSSANAALLVVAAVAAGRLGVPVLLLDPEATSTSTGYADDVLISDHRVPDCDQGVTISPSLACWLAGRTSGSVCALPGDSILFQTSGSTATPRAVVKSVAAVVRDSARVADHLYGDISSAEVVCAAPVFHSYGFTHGLLAGLLVEARTVFRSPSSPPLSLARAAARSGASTLIALPTQVQMIAGSRPSEFAGLKQVVSAGAPLRTETVLRVCGDFGFRLRNAYGASEVGTCAIGTLTATSAPGSVGEPLDGVDVRVEPGDGELMVRNDSFAVGYLADGLLRPLPTEDGWYRTGDLAQRDADGVRITGRRDDLINIAGRKTRRSRLEAVLAAHPDVLEVQVVVAEDEVRGAVPVARVVVKPGHPRPDIVGWSRSRLDPFEAPRQVEWVDRLPRSATGKLIYAASPTEAQR
>CP028158.1|AVT33704.1|7866483_7867692_+|cytochrome-P450
MSSSDREACVSPESEIVDLYQIRDEFYRDPHAVMKSLQESGPVHRVRLPNDLDAWLVVGADVIRELLSEPTFVSGPRFLGVAQEDTGGSSTLGMLTCDEPRHGQLRSLVASTFKPREVARLEPGIEAIANDLLDRLREGEEVDLVEAFAYRLTLEVIIEILGVSSVDRAAFRRWTNETVVDGDDSAAIRAARRHLEDVLARTLREGDGSTLVERIANAGGTADAPPISFDELVSMTYLLLIAGHESATNLIANTLVTVLNSEELVDQIRAGSLPFEELVEESLRFDPPLMISTSRITTCPVSAGGRTIPGGGERVFLAWAAAERDPSVVPDSDTFDPHRRRTRTLAFGGGGHYCLGANLARLEATVALRTLFRRFPSMELVKPPQRWRSTVTRGIESLFVRL
>CP028158.1|AVT33705.1|7867990_7868764_+|hypothetical-protein
MTLRDGLTDAEMARFSEDGFLLLGRFVDDDQLAVLRGIYDQMLARDLGDRLLGTTSDGTAVSLVQVPKPEKLFPELWQTSYFSRSRRLASQLLETPEEELEGVSHLIHKQAMTGRDTPWHQDDACWLAPEFQTHEPRAVTIWIALDDATTTSGCMSFIPGSHTRTARHVFIDDESAFVMVADPATESALQCPMRAGEASIHHCRTVHYAGANTSARQRRAWALEFYASPVPRSEPDPRTWLPEMRERMARRADLRLI
>CP028158.1|AVT33706.1|7868822_7869782_+|epimerase
MRVTVIGGTGHVGGYLVPRLSASGCDVTVVTRGKSTPYRRHGAWDQVELVVADREAEEAAGTFGERIAALDPDVVIDMICFTEESARQLVEAVRGRVGHLLHCGTISVHGPSRVLPTTEAAPRRPIDEYGMGKAAVERYLLDQAHRHGLPATVIHPGHITGPGWVPVNPAGNLDPAVFQRLVDGAELALPNLGLETLQHVHADDVAALFTAAMASRSTAVGESFHSVGATTLTLRGYAEAVAAWYGREANLVFQPYDRWRENVPDRDARATWNHIAHSPHCSMAKAERLLGYRPRFGALEAVQESVDWLVAHGELTAPV
>CP028158.1|AVT35047.1|7869778_7870600_-|LLM-class-F420-dependent-oxidoreductase
MRTYTGPVRIGLELWPQHADYAEIRRAVAEAEEIGVDIIFTWDHFFPVFGDPDGKHFECWTMLGAWAEATTSVEIGALVTCNSYRNPELLADMTRTVDHISDGRLILGIGAGWFERDYLEYGYEFGTAGGRLDNLAEALPRIRSRLGKLNPAPTRKVPVLVGGGGEKRTLKLVAAHADIWHGIGDPAQIERKHRVLDGYCAAIGRDPVEIERSAGVTGPSGIGEPGELAEALYALGTRLFTISSSGPRYDLAPLRSWIDWRDEKNRSVFRRTG
>CP028158.1|AVT33707.1|7870776_7872249_+|carboxylesterase
MDCSPQARIATGVLEGEWKNGIAAFLGIPFAAAPVGANRFAAPRPAPPWDGVRRATEFGSAPPQPRRESEDDDWLNLAVWTPDPGARGLPVLVWISGGAYLQCSTANPHHDGRILAAGGAVVVSVNYRVGAEGWAHLPGYPDNRGLLDQIAALRWVRENIAAFGGAPDNVAVFGQSSGAGSVAALLVMPRAAGLFDRAIVQSLPGTYFTSELAAEVTGRILAELDPSLAPEQLAEVSPQRLTTAVTQMSEELLPTMAARWGPVAYTPTPFSPVVDGEILPVTPWEGLAAGPANQVPMLLGHVRDEGRLLAARLGPAEDAAVDQMINSLAPAADAARYRADFPELAAAELREVALGDWLMRMPTLKLAEAAHRGRVPVWLSELCWGHGPGGAAHTLDALLVFGTADIFGEVTTAGSAKVEEYRRLSELMRTEYLTFAATGDPGWSRFDPDRRATRIYGTDPSVRPYPEQRSQAIWSGHRYPAMDRLTTVAG
>CP028158.1|AVT35048.1|7872308_7873394_-|oxidoreductase
MALIGLGWAVHELWAPLLGGHPGFTVVAVHDPDPVAVRWAGGRFPAARLLNEPGDLRPDEVDLAVVVTPNHLHAPIAISLLERGISTFVEKPVCVSSDEAAALAEAERVGGARLLAGSAAWHRADVTALRTLLPRLGPLRAVELSWIRARGIPAPGGWFTDRRRAGGGALIDLGWHLITIGMRMLSWPRVTQVTCAVSGDFLARAGTEATWRGTGPAAHAAPYAGAPKDVEDTARGVLEIEGGPLVTVCAAWASHSERDVTRVVLDGATGRAELTCTFGLSPNGVGGSTLLLHRDGRAESVDVPQQDRGAEYRRQLDLVPALLADPGRPGSAIAEVTRTIDIIERLYQSAGVPQLTAVRPR
>CP028158.1|AVT33708.1|7873501_7873780_-|hypothetical-protein
MNEAEMVERSAVVRRLMAWVVELVPSCAESGIDEETSLTQFAGFDSIAIVQLLARAEDEFGVDLADEDQTIQSAASVSSLAESIVRLVGCPR

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Crispr_ID: CP028158_18

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028158_18

7965583-7965658

Orphan

Consensus_repeat	Method
CCCCGCGTCGGGCCGGTAGCCGC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of CP028158_18

>merge|CP028158|18|7965583-7965658|CRISPRCasFinder
CCCCGCGTCGGGCCGGTAGCCGCGAACCCCCGGACGAAGCCCTGCCGGCCGGTCCCCGCGTCGGGCCGGTAGCCGC

>CP028158|18|18|7965583-7965658|CRISPRCasFinder
CCCCGCGTCGGGCCGGTAGCCGC	GAACCCCCGGACGAAGCCCTGCCGGCCGGT
CCCCGCGTCGGGCCGGTAGCCGC

Protein	Signature genes	Signature genes Name	Protein_function
CP028158.1\|AVT35067.1\|7956579_7957839_-\|peptidase	unknown	unknown	gnl\|CDD\|320702
CP028158.1\|AVT33768.1\|7960314_7962162_+\|DEDD-exnuclease-domain-containing-protein	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236123
CP028158.1\|AVT33772.1\|7966127_7967039_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|227099
CP028158.1\|AVT33766.1\|7955458_7956583_-\|alpha-(1-2)-phosphatidylinositol-mannosyltransferase	unknown	unknown	gnl\|CDD\|340831
CP028158.1\|AVT35068.1\|7958546_7959857_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377585
CP028158.1\|AVT33773.1\|7967138_7967798_-\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|379301
CP028158.1\|AVT33765.1\|7954613_7955288_-\|thioredoxin	unknown	unknown	gnl\|CDD\|239245
CP028158.1\|AVT33763.1\|7953149_7953818_+\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107
CP028158.1\|AVT33778.1\|7971403_7972252_+\|cytochrome-C	unknown	unknown	gnl\|CDD\|224921
CP028158.1\|AVT33769.1\|7962304_7964086_+\|GTP-pyrophosphokinase	unknown	unknown	gnl\|CDD\|213552
CP028158.1\|AVT33776.1\|7969666_7970620_-\|cytochrome-c-oxidase-assembly-protein	unknown	unknown	gnl\|CDD\|378238
CP028158.1\|AVT33780.1\|7973333_7974956_+\|cytochrome-b	unknown	unknown	gnl\|CDD\|379304
CP028158.1\|AVT33770.1\|7964138_7964675_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240036
CP028158.1\|AVT33767.1\|7958050_7958278_-\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT33774.1\|7967988_7969050_-\|anthranilate-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234682
CP028158.1\|AVT33764.1\|7953989_7954430_-\|DUF4395-domain-containing-protein	unknown	unknown	gnl\|CDD\|379566
CP028158.1\|AVT33775.1\|7969111_7969522_-\|hypothetical-protein	unknown	unknown	unknown
CP028158.1\|AVT33779.1\|7972248_7973337_+\|(2Fe-2S)-binding-protein	unknown	unknown	gnl\|CDD\|239550
CP028158.1\|AVT33771.1\|7965764_7966052_+\|AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366431
CP028158.1\|AVT33777.1\|7970728_7971328_+\|cytochrome-B	unknown	unknown	gnl\|CDD\|224758

Protein	Function_ID	Function_description	E-value
CP028158.1\|AVT35067.1\|7956579_7957839_-\|peptidase	gnl\|CDD\|320702	cd07343, M48A_Zmpste24p_like, Peptidase M48 subfamily A, a type 1 CaaX endopeptidase. This family contains peptidase family M48 subfamily A which includes a number of well-characterized genes such as those found in humans (ZMPSTE24, also known as farnesylated protein-converting enzyme 1 or FACE-1 or Hs Ste24), Taenia solium metacestode (TsSte24p), Arabidopsis (AtSte24) and yeast (Ste24p). Ste24p contains the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. It is thought to be intimately associated with the endoplasmic reticulum (ER), regardless of whether its genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. Ste24p is involved in the post-translational processing of prelamin A to mature lamin A, a major component of the nuclear envelope. ZmpSte24 deficiency causes an accumulation of prelamin A leading to lipodystrophy and other disease phenotypes, while mutations in this gene or in that encoding its substrate, prelamin A, result in a series of human inherited diseases known as laminopathies, the most severe of which are Hutchinson Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) which arise due to unsuccessful maturation of prelamin A. Two forms of mandibuloacral dysplasia, a condition that causes a variety of abnormalities involving bone development, skin pigmentation, and fat distribution, are caused by mutations in two different genes; mutations in the LMNA gene, which normally provides instructions for making lamin A and lamin C, cause mandibuloacral dysplasia with A-type lipodystrophy (MAD-A), and mutations in the ZMPSTE24 gene cause mandibuloacral dysplasia with B-type lipodystrophy (MAD-B). Within cells, these genes are involved in maintaining the structure of the nucleus and may play a role in many cellular processes. Certain HIV protease inhibitors have been shown to inhibit the enzymatic activity of ZMPSTE24, but not enzymes involved in prelamin A processing.	8.13176e-110
CP028158.1\|AVT33768.1\|7960314_7962162_+\|DEDD-exnuclease-domain-containing-protein	gnl\|CDD\|236123	PRK07883, PRK07883, DEDD exonuclease domain-containing protein.	0
CP028158.1\|AVT33776.1\|7969666_7970620_-\|cytochrome-c-oxidase-assembly-protein	gnl\|CDD\|378238	pfam09678, Caa3_CtaG, Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG). Members of this family are the CtaG protein required for assembly of active cytochrome c oxidase of the caa3 type, as found in Bacillus subtilis.	1.7493e-80
CP028158.1\|AVT33766.1\|7955458_7956583_-\|alpha-(1-2)-phosphatidylinositol-mannosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	2.1778e-61
CP028158.1\|AVT33773.1\|7967138_7967798_-\|DUF305-domain-containing-protein	gnl\|CDD\|379301	pfam13628, DUF4142, Domain of unknown function (DUF4142). This is a bacterial family of unknown function.	2.73994e-34
CP028158.1\|AVT33765.1\|7954613_7955288_-\|thioredoxin	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	6.95559e-11
CP028158.1\|AVT33772.1\|7966127_7967039_+\|alpha/beta-hydrolase	gnl\|CDD\|227099	COG4757, COG4757, Predicted alpha/beta hydrolase [General function prediction only].	8.21082e-31
CP028158.1\|AVT33778.1\|7971403_7972252_+\|cytochrome-C	gnl\|CDD\|224921	COG2010, CccA, Cytochrome c, mono- and diheme variants [Energy production and conversion].	3.94741e-10
CP028158.1\|AVT33769.1\|7962304_7964086_+\|GTP-pyrophosphokinase	gnl\|CDD\|213552	TIGR00691, PppGpp_synthetase., (p)ppGpp synthetase, RelA/SpoT family. The functions of E. coli RelA and SpoT differ somewhat. RelA (EC 2.7.6.5) produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT (EC 3.1.7.2) degrades ppGpp, but may also act as a secondary ppGpp synthetase. The two proteins are strongly similar. In many species, a single homolog to SpoT and RelA appears reponsible for both ppGpp synthesis and ppGpp degradation. (p)ppGpp is a regulatory metabolite of the stringent response, but appears also to be involved in antibiotic biosynthesis in some species. [Cellular processes, Adaptations to atypical conditions].	4.83133e-169
CP028158.1\|AVT33780.1\|7973333_7974956_+\|cytochrome-b	gnl\|CDD\|379304	pfam13631, Cytochrom_B_N_2, Cytochrome b(N-terminal)/b6/petB.	6.08645e-68
CP028158.1\|AVT33770.1\|7964138_7964675_+\|NUDIX-hydrolase	gnl\|CDD\|240036	cd04680, Nudix_Hydrolase_21, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	6.10998e-16
CP028158.1\|AVT35068.1\|7958546_7959857_-\|hypothetical-protein	gnl\|CDD\|377585	pfam05991, NYN_YacP, YacP-like NYN domain. This family consists of bacterial proteins related to YacP. This family is uncharacterized functionally, but it has been suggested that these proteins are nucleases due to them containing a NYN domain. NYN (for N4BP1, YacP-like Nuclease) domains were discovered by Anantharaman and Aravind. Based on gene neighborhoods it was suggested that the bacterial YacP proteins interact with the Ribonuclease III and TrmH methylase in a processome complex that catalyzes the maturation of rRNA and tRNA.	2.53659e-20
CP028158.1\|AVT33774.1\|7967988_7969050_-\|anthranilate-phosphoribosyltransferase	gnl\|CDD\|234682	PRK00188, trpD, anthranilate phosphoribosyltransferase; Provisional.	9.68703e-155
CP028158.1\|AVT33764.1\|7953989_7954430_-\|DUF4395-domain-containing-protein	gnl\|CDD\|379566	pfam14340, DUF4395, Domain of unknown function (DUF4395). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 142 and 168 amino acids in length. There are two completely conserved C residues that may be functionally important.	2.1714e-34
CP028158.1\|AVT33779.1\|7972248_7973337_+\|(2Fe-2S)-binding-protein	gnl\|CDD\|239550	cd03467, Rieske, Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. The Rieske domain can be divided into two subdomains, with an incomplete six-stranded, antiparallel beta-barrel at one end, and an iron-sulfur cluster binding subdomain at the other. The Rieske iron-sulfur center contains a [2Fe-2S] cluster, which is involved in electron transfer, and is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs. In RO systems, the N-terminal Rieske domain of the alpha subunit acts as an electron shuttle that accepts electrons from a reductase or ferredoxin component and transfers them to the mononuclear iron in the alpha subunit C-terminal domain to be used for catalysis.	2.56246e-17
CP028158.1\|AVT33777.1\|7970728_7971328_+\|cytochrome-B	gnl\|CDD\|224758	COG1845, CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 [Energy production and conversion].	3.67772e-51
CP028158.1\|AVT33771.1\|7965764_7966052_+\|AsnC-family-transcriptional-regulator	gnl\|CDD\|366431	pfam01037, AsnC_trans_reg, Lrp/AsnC ligand binding domain. The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold.	1.21236e-12
CP028158.1\|AVT33763.1\|7953149_7953818_+\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.92225e-65

>CP028158.1|AVT33770.1|7964138_7964675_+|NUDIX-hydrolase
MISRRSSTRAVGYKIFYRLPIGVRRRLVRLAVPKYIVGAVTLVHDAEAAAPGRILLLRQPPGRKWTLPAGLLQRRESPLVGAARELHEETGIKLPLTEFEPAVPNAVVHLKGWVDMVFQVRVPASTTELVVDGAEVFEAAWHRLDELPPLSTATARLLAHYRIGPLAETDPAGTPPPS
>CP028158.1|AVT33769.1|7962304_7964086_+|GTP-pyrophosphokinase
MDLEAGHGAAFGSARPTEITLSRRLRSLLSWPSAEDDPVTQLVRAHRSVHPSADVGVLRRSYAIAESMHRGQFRKSGEPYITHPLAVAQICAELGMDTVTLVAALLHDTVEDTRYTLQALTGDFGREVAHLVDGVTKFDKAFYGKAAEAETIRKMIIAAGKDVRVLIIKLADRLHNMRTLDARSLASRARIARATQEVLVPLCDRLGIQALKRDLDDVVLRHLEPEAYARIDEYVKSRPDWAGYLDDVVAQAKVVLRRDKIISTVRRRDRHYYSIWKDTVARDQTTPFDLPRIAIVVDGPDTDCYAALGSIHGLWRPVAGRFKDYIAAPKNNLYKSLHTTVIGPDERTVEVLIRTKTMDQSAEYGIAADFRFPKPGVDAAGSAEQLDWLQRVLNWERDTADPAQFLQSLRCDLAETQIQVFAEGRQIVLPAGSTPVDLAYELGPHRGDHCLAAKINGRLAPLSSELDEGDVVEIFSETDAQGEFDLAVAPPGPRKEWLGFVKSPHAQMQINRWFADHQEPAISISDKVRLGRATIGLTLRKHDRGLANDLPLRRLAEEQGYPDLETLLVAVVDRTVEPDTVVEQLIAMVDHQE
>CP028158.1|AVT33768.1|7960314_7962162_+|DEDD-exnuclease-domain-containing-protein
MISPRRPPVTTGTDDTEVSYVPPNLPAVVSPQYVQGTLDGLPDGTPGADGWPDEATSLRQTTFVVLDLETTGGAPDGGGITEIGAVKVRGGEELGVLATLVNPGEPIPPFITVLTGITQAMLLPAPPVEEVLPSLLEFLRGAVLVAHNAPYDVGFLKAACARHGYTWPNPRVLDTAALARRVLTRDEVPNRKLGTLAAYFRTPHQPSHRALADAKATVDVLHGLIARLGGHRVETLGDAIEFAKAVTPTQRRKRHLAEGLPRVPGVYIFRAADDRPLYVGTSGDIATRVRSYFTAAEKRARISEMLAAAERVEAIECAHPLEAEVRELRLIGAHAPPYNRRSKFPERVVWLKLTSEPYPRLSLVRSLGPDDAAYLGPFSSRRSAELAAAGVHDAVPLRQCTPRLSVRTTSPACALAELGRCPAPCEHRISVDEYAHRAVEPVRSALADDPQVLVDALLARIGVLSDAQRYEEAAVVRSRLAAVLRATVRMQRLVGLTRIGELAAARRAADGGWEIAVVRHGRLAGAGTAAPGVPPRRVLDLVRATAETVLPGHGPVPNASAEESERILSWLERPDTRLVETSAGWASPARGAGRFRDLLVRAEAASSRQLPTERT
>CP028158.1|AVT35068.1|7958546_7959857_-|hypothetical-protein
MGDREPEPTLPEPVRARIVSLAAAALPTLPTDELPPPLRRVAKFAPNRRARLGGGPIATQLAADPLFRQRVASRVLAEAGELGSVVVSGASPAAADPVEVAALAYLTRPPGWRDLVEDAGAAVRAEADSAVVAELVREAEQRATRAEHDRAVAKVEADKLRDEVARLREELGQLREENRVLGRTLREAQAGQRRAAELLATEKGRASRAAADHEAELRRVRARLAEAEATAGAVRQTAKEARSVDDARLWLLLETIGRAAVGLRRELALDPADRLPADYVADAFAERPATANSARALDADDPARLDELLALPRAHLVVDGYNVTKRGFGDMSLEQQRKRLITGLGGIAAQTGDEVTVVFDGAERMHGLPPAPRGVRVLFSRKGETADDLIRRLVRAEPAGRPVVVVSSDREVADGVRRHGAYPLGADSLLRRLARS
>CP028158.1|AVT33767.1|7958050_7958278_-|hypothetical-protein
MLIDCDSCTLRRGAACSGCLVSALLDQPPGQASLTADEIHAIEVFTRAGFDVEILDAPVSAPTRLANRRRGRRVA
>CP028158.1|AVT35067.1|7956579_7957839_-|peptidase
MTPRAWAGLTLVALVLLLVAATALLVPWHRPPAPRADQLSALDELDPAEVARGRAFAAALRPGGYGALAVGLVIALLLGLTPLGAKLIALVGRPFGDNWIAQAVLGGLAVVLVADLVTLPFAAWRHAVVARYGLSTQGWGGWTVDLLKSYAVSAVIGAVALLGFYTVTRLAPRWWWAFGAAGAAVLVTLLSFILPVLVEPIFNRFTPMEPGPLRTELMTLADADGVPVKDVLVADASRRTRAVNAYVSGFGPTRRIVVYDTLLREAPPAEVASVVAHELGHAKDRDVLTGTLTGALGAAAAVVALYLLGSSAALLRAAGVDSVAEPRAFPLLLALVTVAGLVATPAQAWVSRQVEARADAHALALTGDPGSFEAMQRRLSSVNLADPDPPRWEYLFRASHPSTVERMAAARAYARGAGG
>CP028158.1|AVT33766.1|7955458_7956583_-|alpha-(1-2)-phosphatidylinositol-mannosyltransferase
MTRTLLVTNDFPPRPGGIQSFVHGLAVRQPPGSVVVYASTWRGADKFDADQPFEVVREPTGVLLPTRHVARRAAELARSYDCDTVWFGAAAPLGLLAAGLRRRAGIGRVVAQTHGHEVGWAALPGARSALRRIGDGVDVTTYLGEYTRVRLDRVLRGRTELRRLAPGVDVDVYHPDVDGAEIRARHGLADRPVVVCVSRLVPRKGQDALIRALPEIRRRVPGAALLVVGGGPYRATLEKLARRAGVAGDVVFTGSVPTAELPAHYAAGDVYAMPCRTRNGGLDVEGLGIVYLEASATGLPVVAGNSGGAPDAVREGETGYVVDGRDVGQLADRVATLLADPELSRRMGAAGRAWVEREWRWERQARRMTEVLTG
>CP028158.1|AVT33765.1|7954613_7955288_-|thioredoxin
MVIDAWTWQSVVVQNAALSGSVAAVATLLLAAGYGLWRRHFDGRLRRQSPTNRLSRAGFGLRSDDGSDPAADLRRQPPAAPPPRPPGADPAAGNGSTPGADPAAGNGSTPGAGVGLPVDPALLAALGVRPGASATLLQFSSAFCAPCRATRQVLADVTETLDGVRHVEVDAESQLPAVRALGIWRTPTVLLVDADGRIVQRAAGVPARAQVLAAVAPLLRRGPS
>CP028158.1|AVT33764.1|7953989_7954430_-|DUF4395-domain-containing-protein
MLLDPRGPRFAAVVTTLVLVVVLVTGSGWLALAQAVVFAIAAVDPRRSPYGLLFRAVLAPRLARPAELEPVAPVRFAQLLGLGFMLVAAAGYLSGATWLGLVVSCLALAAAFLNGAFGLCLGCETYLAFRRMTGRAIPARVPNPSN
>CP028158.1|AVT33763.1|7953149_7953818_+|DNA-binding-response-regulator
MTTSPMPTTRTKVLLVDDHDLIRKGLRHAFERDRQFEVVGEAATAAEGVRQAGALQPDVVIMDLRLPDGSGLEATRALRKSSATMGIVVLTMYAGDDQLFGALEAGASAFVPKTAPADEVVAAARHAASSPSAFTAADLAEAMKRRLAPSGPQLSPREGQVLRLLADGMSVAGIAKQLFVSESTAKTHISKLYEKLGAANRAQALMTALRLGLLEAPDAPKF
>CP028158.1|AVT33771.1|7965764_7966052_+|AsnC-family-transcriptional-regulator
MITAIVLIDCATDSIPEVAETLAAVPGVSEVYSVAGHVDLIAVVRVREFEQIAEVIAGRISKVPGVLGTESHIAFRAYSQHDLEEAFAIGLPDPD
>CP028158.1|AVT33772.1|7966127_7967039_+|alpha/beta-hydrolase
MTSTPDQPPQPTPPSQPDSSQPGYEESFVDRDGDRIALRSYPDPVGAPEAPVVLLWPAMGVRASYYAPFAAALRSAGLAVVVADLRGTGASTPAPSRASRYGYAELAGDVGAVLESLKPRLDGRQRILLGHSLGGQAALLHLALDPSTPVDGLALVAVGLPYWRAYPDRRLAMLAGTQLIHGCAAVLGSWPGWGFGGRQARGVIRDWAYTARTGRFPRLDGVDVEAAVREVRTPVLAVSVDHDQYTPHGTVDYLCDKLVAAPVRRTRYTLAESGTRLDHFTWVRASAPVAARVAEFVADLPHR
>CP028158.1|AVT33773.1|7967138_7967798_-|DUF305-domain-containing-protein
MLVVKRLGVLVSMAVLGLVPAGAAYSAAAAPSGTPSATPSASLSAQDRQFLQSIHQVNLAEIATGNLAKQKGASQEVKDLGGRLVTDHTQLDQKVQSVASAASLTLPNKVTSEQQAVINQLQNVTGTDFDTQWVTAQLTAHTQAMQLVQAELTQGSDPSAKQVAQQAAPVLQAHHHALVAVAQSLGIPIPGGTTVAPSPGISSGAPTPGGTVTPSPTIS
>CP028158.1|AVT33774.1|7967988_7969050_-|anthranilate-phosphoribosyltransferase
MGERTWPNLLAALLRDEELSTADTAWAMGEIMSGSATPAQIAGFATALRAKGETPAELAGLVEAMLGRATLVELPEALRVDALDVVGTGGDRAHTVNISTMTAMVVAGAGVRVVKHGNRAASSSCGAADLLEFLGVPLDLGPAGVARCVTEVGIGFCFAARFHPGMRHTAVPRREMGVPTVFNFLGPLTNPARPRSGAVGCFDSRMAPVVAEVFAQRGDSVLVMRGEDGLDEFSTAAPTRLWIAHEGRVTETLADAADLGLPRSAPGDLRGGDAAFNADVTRRLLAGERGPVRDAVLVNAAAALAAHGSFSGGLLPAMRDGLARAAESIDSGAAARTLDTWVEIAKTAKAAEL
>CP028158.1|AVT33775.1|7969111_7969522_-|hypothetical-protein
MSDRQYTVLLYSDDPEVRDRMRLAVGTRPAADLTVEFVDAASYDECIRLVDDYEIDLLLLDGEASPTGGLGIARQIKDDRDDAPPTCVVIARAADRWLAAYAQVDATLVHPLDPVTTGQTVAGLLRARASGASARS
>CP028158.1|AVT33776.1|7969666_7970620_-|cytochrome-c-oxidase-assembly-protein
MLHLDPGTASAVPPAPAVLAGGGAETAPFTVSTIFTEATLNSWLAVGLVLAAACYLYGVHRLRVRGHSWPVLRTVLFLGPGLGGIAAVTLTGLGAYDTTLISVHMVQHMVLSMVAPIFLALGAPVTLALRTLGKAPRKRLLAVLHSRVARVFTFPLFAYAIFVVNPFVLYFSGLYRWTLENSFGHELVHAHFILTGCLFFWPLVGLDPLPGRWPYPARALLMVLSVPFHTVLGLTVMQSTTLFGGDWYPSLALAWSDPWNDQKVAGGILWAGGEFVSVTMLGVLVVQWVRQSEREARRTDRELDRQEARERAAGTAV
>CP028158.1|AVT33777.1|7970728_7971328_+|cytochrome-B
MTAASAIDKSRIHSLTRPNMVSVGTIVWLSSELMFFAALFAMYFSIRAAAPEQWEKHTEVLNIPYATTFTVILVLSSVTCQIGVFAAERGDVHALRRWFTITFVMGLIFVLGQLNEYRELVHHGVKINADGYGSVFYLTTGFHALHVTGGLVAFIIFMIRTTMGRFTPAQATSAIVVSYYWHFVDVVWIALYGMIYWLQ
>CP028158.1|AVT33778.1|7971403_7972252_+|cytochrome-C
MTSDTPGGDRSRGLLSRLRRARSRPRGKARRRLGAAVRLLAALMLAGGAYTVFAPGLSAQDTPQLTSAAQEGKALFDTSCVSCHGRNAQGVEGRGPSLIGVGAASVEFQVSTGRMPLARQEAQAEEKPPVFTDDQTTQLAQYVQELGGGPQLPEGENLHQGGDAAEGGRLFRINCSSCHAFGGGGGALSSGKFAPSLRDATDRQIYGAMLTGPQNMPVFGDNQIRPDQKADIIAYLNETVQSDRDPGGFNLGRYGPATEALVIFLVGIVALIFAALWIAGKS
>CP028158.1|AVT33779.1|7972248_7973337_+|(2Fe-2S)-binding-protein
MSTANDVQPHGAGQQPVDLDDPTLSRFDIVREGARRDDIEIVHYEAQFPVPGTKAERRLTRTITLMFLLVGVLATAFLAIYIWWPWTFESQDGLGVLYTPLLGITLGLALLLIGFGLLAWGKKLLPKEVSIQGRHDEHVTDDERKLTGNTMLYLADEMGVRRRPLLGISLLAGLAPVGAVAAAPLIGGMIEQPHKNNQMFTTGWKPQDGRRIHLTHHDGTPIRPEDISPGGMLTVYPGIEGGATNKWADSPVLLFHLRERDAADAKAANVRDNKPNFMWGNYIAYSKICTHAGCPASLYEQQTNRLLCPCHQSQFLITDNARPVFGPANRRLPQLPLDVEGGFFVAKSDFTETVGPDFWERP
>CP028158.1|AVT33780.1|7973333_7974956_+|cytochrome-b
MKRRRLDVAAVPGKAAREVDDRLQVATPLRSLLNKVFPDHWSFLLGEIALFSFIVLLLTGVYLTLFFEPSMREVTYDGSYRPLQGVHMSAAYSSSLDISFDIRGGLIMRQMHHWAALLFMAAIIVHMMRIFFTGAFRKPRELNWIIGYLLFWVGFLAGFTGYSLPDDGLSGTGLRIASAIMLSIPVIGTWVTSSIFAGEFPGEIIVSRFFIAHVLLIPALLVALISVHLGLVFKQKHTQWPGPGRTNSNVVGERMFPRYALKQGGFFMIVFGVIALLGGVAQINPIWFFGPYEAGVVSAASQPDWYVMFLDGSTRLMPPWQISIPIGDGYVIPPLFWPTVVLPGILTVVPLLYPFIEARINKDRRTHHLLQRPRDVPGRTALGAMAVSFWLVLTLSGANDVIAEKFWISLNAMTWAGRIGLIIVPPIAYYITYRICLGLQQHDREVLAHGVETGIIRRLPNGQFVEVHQPLGRTDEHGHSELEYVGWVVPKKMNRLGALGPAIRGFFYPIEKPAEAPVSPGHPPVEPRPEREEIGSGDRR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP028158_1	1.2\|131687\|19\|CP028158\|CRISPRCasFinder	131687-131705	19	CP028158.1	131717-131735	0	1.0
CP028158_1	1.2\|131687\|19\|CP028158\|CRISPRCasFinder	131687-131705	19	CP028158.1	131732-131750	0	1.0

1. spacer 1.2|131687|19|CP028158|CRISPRCasFinder matches to position: 131717-131735, mismatch: 0, identity: 1.0

ggctggcgtggcggtggct	CRISPR spacer
ggctggcgtggcggtggct	Protospacer
*******************

2. spacer 1.2|131687|19|CP028158|CRISPRCasFinder matches to position: 131732-131750, mismatch: 0, identity: 1.0

ggctggcgtggcggtggct	CRISPR spacer
ggctggcgtggcggtggct	Protospacer
*******************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP028158_7	7.1\|4813316\|28\|CP028158\|CRISPRCasFinder	4813316-4813343	28	NZ_CP029232	Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence	1468767-1468794	5	0.821
CP028158_7	7.1\|4813316\|28\|CP028158\|CRISPRCasFinder	4813316-4813343	28	NZ_CP024314	Rhizobium sp. NXC24 plasmid pRspNXC24c, complete sequence	395175-395202	5	0.821
CP028158_7	7.1\|4813316\|28\|CP028158\|CRISPRCasFinder	4813316-4813343	28	NZ_LR723669	Rhizobium sp. Khangiran2 plasmid 2	84533-84560	6	0.786
CP028158_7	7.1\|4813316\|28\|CP028158\|CRISPRCasFinder	4813316-4813343	28	NZ_AP014659	Bradyrhizobium diazoefficiens strain NK6 plasmid pNK6a, complete sequence	22871-22898	6	0.786
CP028158_9	9.1\|6920442\|28\|CP028158\|CRISPRCasFinder	6920442-6920469	28	NZ_CP051294	Mesorhizobium sp. NZP2077 plasmid pMSNZP2077A, complete sequence	83111-83138	6	0.786
CP028158_9	9.1\|6920442\|28\|CP028158\|CRISPRCasFinder	6920442-6920469	28	NZ_CP051294	Mesorhizobium sp. NZP2077 plasmid pMSNZP2077A, complete sequence	205149-205176	6	0.786
CP028158_9	9.1\|6920442\|28\|CP028158\|CRISPRCasFinder	6920442-6920469	28	NZ_CP051294	Mesorhizobium sp. NZP2077 plasmid pMSNZP2077A, complete sequence	273779-273806	6	0.786
CP028158_9	9.1\|6920442\|28\|CP028158\|CRISPRCasFinder	6920442-6920469	28	NZ_CP033363	Mesorhizobium sp. NZP2077 plasmid pMSNZP2077NSa, complete sequence	83111-83138	6	0.786
CP028158_9	9.1\|6920442\|28\|CP028158\|CRISPRCasFinder	6920442-6920469	28	NZ_CP033363	Mesorhizobium sp. NZP2077 plasmid pMSNZP2077NSa, complete sequence	205149-205176	6	0.786
CP028158_9	9.1\|6920442\|28\|CP028158\|CRISPRCasFinder	6920442-6920469	28	NZ_CP033363	Mesorhizobium sp. NZP2077 plasmid pMSNZP2077NSa, complete sequence	273776-273803	6	0.786
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	AP014720	Arthrobacter sp. Hiyo8 plasmid pHiyo8-1 DNA, complete genome, strain: Hiyo8	270951-270979	6	0.793
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	253548-253576	6	0.793
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP026518	Deinococcus sp. NW-56 plasmid unnamed2, complete sequence	256982-257010	6	0.793
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP046573	Rhodococcus sp. WAY2 plasmid pRWAY01, complete sequence	843893-843921	6	0.793
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP032349	Azospirillum brasilense strain MTCC4039 plasmid p3, complete sequence	552250-552278	6	0.793
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NC_009470	Acidiphilium cryptum JF-5 plasmid pACRY04, complete sequence	14229-14257	6	0.793
CP028158_13	13.1\|7230930\|28\|CP028158\|CRISPRCasFinder	7230930-7230957	28	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	1372771-1372798	6	0.786
CP028158_13	13.1\|7230930\|28\|CP028158\|CRISPRCasFinder	7230930-7230957	28	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	1377439-1377466	6	0.786
CP028158_14	14.1\|7586437\|46\|CP028158\|CRISPRCasFinder	7586437-7586482	46	NZ_CP045310	Micromonospora terminaliae strain DSM 101760 plasmid pLB1, complete sequence	7733-7778	6	0.87
CP028158_14	14.1\|7586437\|46\|CP028158\|CRISPRCasFinder	7586437-7586482	46	NZ_CP045310	Micromonospora terminaliae strain DSM 101760 plasmid pLB1, complete sequence	5025-5070	6	0.87
CP028158_9	9.1\|6920442\|28\|CP028158\|CRISPRCasFinder	6920442-6920469	28	MH727561	Mycobacterium phage Serendipitous, complete genome	29090-29117	7	0.75
CP028158_9	9.1\|6920442\|28\|CP028158\|CRISPRCasFinder	6920442-6920469	28	NC_022063	Mycobacterium phage Phelemich, complete genome	29539-29566	7	0.75
CP028158_9	9.1\|6920442\|28\|CP028158\|CRISPRCasFinder	6920442-6920469	28	KF024727	Mycobacterium phage Reprobate, complete genome	29544-29571	7	0.75
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP017782	Rhodobacter sp. LPB0142 plasmid pEJ01, complete sequence	7564-7592	7	0.759
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP017782	Rhodobacter sp. LPB0142 plasmid pEJ01, complete sequence	116840-116868	7	0.759
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	1501798-1501826	7	0.759
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	MF140434	Arthrobacter phage Wheelbite, complete genome	2126-2154	7	0.759
CP028158_13	13.1\|7230930\|28\|CP028158\|CRISPRCasFinder	7230930-7230957	28	NZ_CP027025	Streptomyces sp. WAC00288 plasmid p3, complete sequence	35185-35212	7	0.75
CP028158_18	18.1\|7965606\|30\|CP028158\|CRISPRCasFinder	7965606-7965635	30	NZ_CP054615	Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence	250797-250826	7	0.767
CP028158_18	18.1\|7965606\|30\|CP028158\|CRISPRCasFinder	7965606-7965635	30	NZ_CP039644	Azospirillum sp. TSA2s plasmid p2, complete sequence	325176-325205	7	0.767
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	699904-699932	8	0.724
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP029358	Azospirillum sp. CFH 70021 plasmid unnamed3	400202-400230	8	0.724
CP028158_18	18.1\|7965606\|30\|CP028158\|CRISPRCasFinder	7965606-7965635	30	NC_012810	Methylorubrum extorquens AM1 plasmid p3META1, complete sequence	21006-21035	8	0.733
CP028158_18	18.1\|7965606\|30\|CP028158\|CRISPRCasFinder	7965606-7965635	30	NZ_CP016082	Streptomyces sp. SAT1 plasmid unnamed2, complete sequence	112699-112728	8	0.733
CP028158_18	18.1\|7965606\|30\|CP028158\|CRISPRCasFinder	7965606-7965635	30	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	705809-705838	8	0.733
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP033323	Azospirillum brasilense strain Cd plasmid p5, complete sequence	227645-227673	9	0.69
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP012919	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p5, complete sequence	3102-3130	9	0.69
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP012919	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p5, complete sequence	151791-151819	9	0.69
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP032344	Azospirillum brasilense strain MTCC4038 plasmid p5, complete sequence	31655-31683	9	0.69
CP028158_11	11.1\|7126669\|29\|CP028158\|CRISPRCasFinder	7126669-7126697	29	NZ_CP033317	Azospirillum brasilense strain Sp 7 plasmid p5, complete sequence	103915-103943	9	0.69

1. spacer 7.1|4813316|28|CP028158|CRISPRCasFinder matches to NZ_CP029232 (Sinorhizobium fredii CCBAU 45436 plasmid pSF45436b, complete sequence) position: , mismatch: 5, identity: 0.821

tgctctcctcggccttcttgctctcttc	CRISPR spacer
ttatggcctcggccttcttgatctcttc	Protospacer
*  *  ************** *******

2. spacer 7.1|4813316|28|CP028158|CRISPRCasFinder matches to NZ_CP024314 (Rhizobium sp. NXC24 plasmid pRspNXC24c, complete sequence) position: , mismatch: 5, identity: 0.821

-tgctctcctcggccttcttgctctcttc	CRISPR spacer
atgc-ctcctcggccttcttgcgctcagt	Protospacer
 *** ***************** ***  .

3. spacer 7.1|4813316|28|CP028158|CRISPRCasFinder matches to NZ_LR723669 (Rhizobium sp. Khangiran2 plasmid 2) position: , mismatch: 6, identity: 0.786

tgctctcctcggccttcttgctctcttc	CRISPR spacer
ctcactcctcggcgttcttgctctctgg	Protospacer
. * ********* ************

4. spacer 7.1|4813316|28|CP028158|CRISPRCasFinder matches to NZ_AP014659 (Bradyrhizobium diazoefficiens strain NK6 plasmid pNK6a, complete sequence) position: , mismatch: 6, identity: 0.786

tgctctcctcggccttcttgctctcttc	CRISPR spacer
ctatttcctcggccttcttgcgctcatc	Protospacer
.  *.**************** *** **

5. spacer 9.1|6920442|28|CP028158|CRISPRCasFinder matches to NZ_CP051294 (Mesorhizobium sp. NZP2077 plasmid pMSNZP2077A, complete sequence) position: , mismatch: 6, identity: 0.786

actcgcgctctacacgcagctctccgag	CRISPR spacer
cttcgcgctcaacacccagctctcctat	Protospacer
 .******** **** ********* *

6. spacer 9.1|6920442|28|CP028158|CRISPRCasFinder matches to NZ_CP051294 (Mesorhizobium sp. NZP2077 plasmid pMSNZP2077A, complete sequence) position: , mismatch: 6, identity: 0.786

actcgcgctctacacgcagctctccgag	CRISPR spacer
cttcgcgctcaacacccagctctcctat	Protospacer
 .******** **** ********* *

7. spacer 9.1|6920442|28|CP028158|CRISPRCasFinder matches to NZ_CP051294 (Mesorhizobium sp. NZP2077 plasmid pMSNZP2077A, complete sequence) position: , mismatch: 6, identity: 0.786

actcgcgctctacacgcagctctccgag	CRISPR spacer
cttcgcgctcaacacccagctctcctat	Protospacer
 .******** **** ********* *

8. spacer 9.1|6920442|28|CP028158|CRISPRCasFinder matches to NZ_CP033363 (Mesorhizobium sp. NZP2077 plasmid pMSNZP2077NSa, complete sequence) position: , mismatch: 6, identity: 0.786

actcgcgctctacacgcagctctccgag	CRISPR spacer
cttcgcgctcaacacccagctctcctat	Protospacer
 .******** **** ********* *

9. spacer 9.1|6920442|28|CP028158|CRISPRCasFinder matches to NZ_CP033363 (Mesorhizobium sp. NZP2077 plasmid pMSNZP2077NSa, complete sequence) position: , mismatch: 6, identity: 0.786

actcgcgctctacacgcagctctccgag	CRISPR spacer
cttcgcgctcaacacccagctctcctat	Protospacer
 .******** **** ********* *

10. spacer 9.1|6920442|28|CP028158|CRISPRCasFinder matches to NZ_CP033363 (Mesorhizobium sp. NZP2077 plasmid pMSNZP2077NSa, complete sequence) position: , mismatch: 6, identity: 0.786

actcgcgctctacacgcagctctccgag	CRISPR spacer
cttcgcgctcaacacccagctctcctat	Protospacer
 .******** **** ********* *

11. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to AP014720 (Arthrobacter sp. Hiyo8 plasmid pHiyo8-1 DNA, complete genome, strain: Hiyo8) position: , mismatch: 6, identity: 0.793

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
ggcagccgctgccgcggcggacccggcac	Protospacer
   * *** *** ****************

12. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.793

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
ctcggccggtgcggcggcggccccggagc	Protospacer
** . *************** ***** .*

13. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP026518 (Deinococcus sp. NW-56 plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.793

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
ccgaggtcgtgcggctgcggacccggcac	Protospacer
*.**  . ******* *************

14. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP046573 (Rhodococcus sp. WAY2 plasmid pRWAY01, complete sequence) position: , mismatch: 6, identity: 0.793

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
acgacccggtgggacggcggacccgacgc	Protospacer
 .********* *.***********.*.*

15. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP032349 (Azospirillum brasilense strain MTCC4039 plasmid p3, complete sequence) position: , mismatch: 6, identity: 0.793

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
cgcgcccggtgcggtggcggccccggcgc	Protospacer
*  .**********.***** ******.*

16. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NC_009470 (Acidiphilium cryptum JF-5 plasmid pACRY04, complete sequence) position: , mismatch: 6, identity: 0.793

ctgac--ccggtgcggcggcggacccggcac	CRISPR spacer
--ggccaccagtgcggcgacggacccggcaa	Protospacer
  *.*  **.********.***********

17. spacer 13.1|7230930|28|CP028158|CRISPRCasFinder matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 6, identity: 0.786

acgcgaacaacccggcgcggccagcaac	CRISPR spacer
tcggcgacaacccggcgcgggcagcaag	Protospacer
 **  .************** ******

18. spacer 13.1|7230930|28|CP028158|CRISPRCasFinder matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 6, identity: 0.786

acgcgaacaacccggcgcggccagcaac	CRISPR spacer
tcggcgacaacccggcgcgggcagcaag	Protospacer
 **  .************** ******

19. spacer 14.1|7586437|46|CP028158|CRISPRCasFinder matches to NZ_CP045310 (Micromonospora terminaliae strain DSM 101760 plasmid pLB1, complete sequence) position: , mismatch: 6, identity: 0.87

tgcggctgtgagcgcgaggagtgagccggtgttgcgagccccgcaa	CRISPR spacer
tgaccgagtgagcgcgaggagtgagccggtgttgcgagccccgcag	Protospacer
**     **************************************.

20. spacer 14.1|7586437|46|CP028158|CRISPRCasFinder matches to NZ_CP045310 (Micromonospora terminaliae strain DSM 101760 plasmid pLB1, complete sequence) position: , mismatch: 6, identity: 0.87

tgcggctgtgagcgcgaggagtgagccggtgttgcgagccccgcaa	CRISPR spacer
tgaccgagtgagcgcgaggagtgagccggtgttgcgagccccgcag	Protospacer
**     **************************************.

21. spacer 9.1|6920442|28|CP028158|CRISPRCasFinder matches to MH727561 (Mycobacterium phage Serendipitous, complete genome) position: , mismatch: 7, identity: 0.75

actcgcgctctacacgcagctctccgag	CRISPR spacer
ggcagcgctctacacgcagctcaccggc	Protospacer
. . ****************** ***.

22. spacer 9.1|6920442|28|CP028158|CRISPRCasFinder matches to NC_022063 (Mycobacterium phage Phelemich, complete genome) position: , mismatch: 7, identity: 0.75

actcgcgctctacacgcagctctccgag	CRISPR spacer
gtcggcgctctacacgcagctcaccggc	Protospacer
... ****************** ***.

23. spacer 9.1|6920442|28|CP028158|CRISPRCasFinder matches to KF024727 (Mycobacterium phage Reprobate, complete genome) position: , mismatch: 7, identity: 0.75

actcgcgctctacacgcagctctccgag	CRISPR spacer
gtcggcgctctacacgcagctcaccggc	Protospacer
... ****************** ***.

24. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP017782 (Rhodobacter sp. LPB0142 plasmid pEJ01, complete sequence) position: , mismatch: 7, identity: 0.759

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
gatgcccggtgcggcggcagaccgggcaa	Protospacer
   .**************.**** ****

25. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP017782 (Rhodobacter sp. LPB0142 plasmid pEJ01, complete sequence) position: , mismatch: 7, identity: 0.759

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
gatgcccggtgcggcggcagaccgggcaa	Protospacer
   .**************.**** ****

26. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 7, identity: 0.759

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
gctccccggtgcggcggcggccccggtgc	Protospacer
 .  **************** *****..*

27. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to MF140434 (Arthrobacter phage Wheelbite, complete genome) position: , mismatch: 7, identity: 0.759

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
cctccccggtgcggcggcggccccgggcg	Protospacer
*.  **************** *****

28. spacer 13.1|7230930|28|CP028158|CRISPRCasFinder matches to NZ_CP027025 (Streptomyces sp. WAC00288 plasmid p3, complete sequence) position: , mismatch: 7, identity: 0.75

acgcgaacaacccggcgcggccagcaac	CRISPR spacer
ccgcgaccaacccgccgcggccagtcca	Protospacer
 ***** ******* *********.

29. spacer 18.1|7965606|30|CP028158|CRISPRCasFinder matches to NZ_CP054615 (Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

gaacccccggacgaagccctgccggccggt	CRISPR spacer
ggccacccggacgaagaccagccggccgca	Protospacer
*. * *********** ** ********

30. spacer 18.1|7965606|30|CP028158|CRISPRCasFinder matches to NZ_CP039644 (Azospirillum sp. TSA2s plasmid p2, complete sequence) position: , mismatch: 7, identity: 0.767

gaacccccggacgaagccctgccggccggt	CRISPR spacer
ggccacccggacgaagaccagccggccgca	Protospacer
*. * *********** ** ********

31. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 8, identity: 0.724

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
gcgagccggtgcggcggcggaccggtgga	Protospacer
 .** ****************** *  .

32. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP029358 (Azospirillum sp. CFH 70021 plasmid unnamed3) position: , mismatch: 8, identity: 0.724

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
gccgcccggtccggcggcggagccggccg	Protospacer
 . .****** ********** *****

33. spacer 18.1|7965606|30|CP028158|CRISPRCasFinder matches to NC_012810 (Methylorubrum extorquens AM1 plasmid p3META1, complete sequence) position: , mismatch: 8, identity: 0.733

gaacccccggacgaagccctgccggccggt	CRISPR spacer
agcgccccgcacgaagcccggccggccgaa	Protospacer
..  ***** ********* ********.

34. spacer 18.1|7965606|30|CP028158|CRISPRCasFinder matches to NZ_CP016082 (Streptomyces sp. SAT1 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

gaacccccggacgaagccctgccggccggt	CRISPR spacer
ccaagaccggacgaagccctgtcgaccggg	Protospacer
  *   ***************.**.****

35. spacer 18.1|7965606|30|CP028158|CRISPRCasFinder matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.733

gaacccccggacgaagccctgccggccggt	CRISPR spacer
ccaagaccggacgaagccctgtcgaccggg	Protospacer
  *   ***************.**.****

36. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP033323 (Azospirillum brasilense strain Cd plasmid p5, complete sequence) position: , mismatch: 9, identity: 0.69

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
gcaccccggtgcggcggcggacgcgttcg	Protospacer
 .. ****************** ** .

37. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP012919 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p5, complete sequence) position: , mismatch: 9, identity: 0.69

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
gcaccccggtgcggcggcggacgcgttcg	Protospacer
 .. ****************** ** .

38. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP012919 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p5, complete sequence) position: , mismatch: 9, identity: 0.69

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
gcaccccggtgcggcggcggacgcgttcg	Protospacer
 .. ****************** ** .

39. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP032344 (Azospirillum brasilense strain MTCC4038 plasmid p5, complete sequence) position: , mismatch: 9, identity: 0.69

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
gcaccccggtgcggcggcggacgcgttcg	Protospacer
 .. ****************** ** .

40. spacer 11.1|7126669|29|CP028158|CRISPRCasFinder matches to NZ_CP033317 (Azospirillum brasilense strain Sp 7 plasmid p5, complete sequence) position: , mismatch: 9, identity: 0.69

ctgacccggtgcggcggcggacccggcac	CRISPR spacer
gcaccccggtgcggcggcggacgcgttcg	Protospacer
 .. ****************** ** .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage