CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP020645	Bordetella bronchiseptica strain I943 chromosome, complete genome	15 crisprs	PD-DExK,RT,csa3,DEDDh,DinG,cas3	2	3	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP020645_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_1

91544-91652

Orphan

Consensus_repeat	Method
ATGGGGACTGGCTCCCGCCAACTTCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_1

>merge|CP020645|1|91544-91652|CRISPRCasFinder
ATGGGGACTGGCTCCCGCCAACTTCAGGAGCCTGTTCGCGCATGGGGACTGGCTCCCGCCAACTTCCGGAGCCTGTTCGCGTATGGGGACTGGCTCCCGCCAACTTCAG

>CP020645|1|1|91544-91652|CRISPRCasFinder
ATGGGGACTGGCTCCCGCCAACTTCAG	GAGCCTGTTCGCGCATGGGGACTGGCTCCCGCCAACTTCCGGAGCCTGTTCGCGT
ATGGGGACTGGCTCCCGCCAACTTCAG

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP56539.1\|87557_88559_+\|taurine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270281
CP020645.1\|AWP56542.1\|90199_91516_+\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223737
CP020645.1\|AWP56538.1\|86560_87532_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
CP020645.1\|AWP56552.1\|100915_101815_+\|4-hydroxy-tetrahydrodipicolinate-synthase	unknown	unknown	gnl\|CDD\|188637
CP020645.1\|AWP56541.1\|89380_90172_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|213260
CP020645.1\|AWP56540.1\|88622_89393_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
CP020645.1\|AWP56534.1\|81765_83256_+\|ethylammeline-chlorohydrolase	unknown	unknown	gnl\|CDD\|180428
CP020645.1\|AWP56544.1\|91913_92558_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
CP020645.1\|AWP56536.1\|84433_85579_+\|glycosyltransferase-family-1-protein	unknown	unknown	gnl\|CDD\|340831
CP020645.1\|AWP56549.1\|97782_98709_-\|4-hydroxybenzoate-octaprenyltransferase	unknown	unknown	gnl\|CDD\|237229
CP020645.1\|AWP56543.1\|91716_91857_-\|hypothetical-protein	unknown	unknown	unknown
CP020645.1\|AWP56533.1\|80544_81486_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176109
CP020645.1\|AWP56548.1\|97130_97517_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379321
CP020645.1\|AWP56550.1\|98795_99995_-\|aminotransferase	unknown	unknown	gnl\|CDD\|224089
CP020645.1\|AWP56535.1\|83294_84281_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270296
CP020645.1\|AWP56545.1\|92593_94771_-\|malate-synthase-G	unknown	unknown	gnl\|CDD\|235097
CP020645.1\|AWP56537.1\|85585_86404_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378479
CP020645.1\|AWP56546.1\|95014_95779_+\|transcriptional-regulator-GlcC	unknown	unknown	gnl\|CDD\|182186
CP020645.1\|AWP56547.1\|95775_96903_-\|saccharopine-dehydrogenase	unknown	unknown	gnl\|CDD\|224662
CP020645.1\|AWP56551.1\|100133_100628_+\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|224867

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP56539.1\|87557_88559_+\|taurine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270281	cd13563, PBP2_SsuA_like_6, Putative substrate binding domain of sulfonate binding protein-like, a member of the type 2 periplasmic binding protein fold. This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.72082e-76
CP020645.1\|AWP56542.1\|90199_91516_+\|FAD-dependent-oxidoreductase	gnl\|CDD\|223737	COG0665, DadA, Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism].	1.22821e-37
CP020645.1\|AWP56538.1\|86560_87532_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.24845e-38
CP020645.1\|AWP56552.1\|100915_101815_+\|4-hydroxy-tetrahydrodipicolinate-synthase	gnl\|CDD\|188637	cd00950, DHDPS, Dihydrodipicolinate synthase (DHDPS). Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis. It catalyzes the aldol condensation of L-aspartate-beta- semialdehyde and pyruvate to dihydropicolinic acid via a Schiff base formation between pyruvate and a lysine residue. The functional enzyme is a homotetramer consisting of a dimer of dimers. DHDPS is member of dihydrodipicolinate synthase family that comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways.	1.73457e-114
CP020645.1\|AWP56541.1\|89380_90172_+\|ATP-binding-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	4.99525e-128
CP020645.1\|AWP56540.1\|88622_89393_+\|ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	8.67508e-74
CP020645.1\|AWP56534.1\|81765_83256_+\|ethylammeline-chlorohydrolase	gnl\|CDD\|180428	PRK06151, PRK06151, N-ethylammeline chlorohydrolase; Provisional.	0
CP020645.1\|AWP56544.1\|91913_92558_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.89212e-08
CP020645.1\|AWP56536.1\|84433_85579_+\|glycosyltransferase-family-1-protein	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	3.42512e-68
CP020645.1\|AWP56549.1\|97782_98709_-\|4-hydroxybenzoate-octaprenyltransferase	gnl\|CDD\|237229	PRK12848, ubiA, 4-hydroxybenzoate octaprenyltransferase.	1.64233e-139
CP020645.1\|AWP56533.1\|80544_81486_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176109	cd08417, PBP2_Nitroaromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of dinitrotoluene and similar compounds, such as DntR, NahR, and LinR. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. Also included are related LysR-type regulators clustered together in phylogenetic trees, including NodD, ToxR, LeuO, SyrM, TdcA, and PnbR. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	5.33388e-64
CP020645.1\|AWP56548.1\|97130_97517_-\|hypothetical-protein	gnl\|CDD\|379321	pfam13663, DUF4148, Domain of unknown function (DUF4148).	4.57948e-06
CP020645.1\|AWP56550.1\|98795_99995_-\|aminotransferase	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	1.31005e-141
CP020645.1\|AWP56535.1\|83294_84281_+\|hypothetical-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	3.97136e-116
CP020645.1\|AWP56545.1\|92593_94771_-\|malate-synthase-G	gnl\|CDD\|235097	PRK02999, PRK02999, malate synthase G; Provisional.	0
CP020645.1\|AWP56537.1\|85585_86404_+\|hypothetical-protein	gnl\|CDD\|378479	pfam10707, YrbL-PhoP_reg, PhoP regulatory network protein YrbL. This is a family of proteins that are activated by PhoP. PhoP protein controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multicomponent loop in Salmonella where the PhoP-dependent PmrD protein activates the regulatory protein PmrA, and the activated PmrA then represses transcription from the PmrD promoter which harbours binding sites for both the PhoP and PmrA proteins. Expression of YrbL is induced in low Mg2+ in a PhoP-dependent fashion and repressed by Fe3+ in a PmrA-dependent manner.	6.59819e-92
CP020645.1\|AWP56546.1\|95014_95779_+\|transcriptional-regulator-GlcC	gnl\|CDD\|182186	PRK09990, PRK09990, DNA-binding transcriptional regulator GlcC; Provisional.	3.60603e-150
CP020645.1\|AWP56547.1\|95775_96903_-\|saccharopine-dehydrogenase	gnl\|CDD\|224662	COG1748, LYS9, Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism].	2.22825e-74
CP020645.1\|AWP56551.1\|100133_100628_+\|diguanylate-cyclase	gnl\|CDD\|224867	COG1956, COG1956, GAF domain-containing protein [Signal transduction mechanisms].	6.09219e-80

>CP020645.1|AWP56542.1|90199_91516_+|FAD-dependent-oxidoreductase
MSSPSGSSRTFPQYQSGSGWNAMLPKRTPRTAAPARRHFKSLVIGAGYTGLAAARRLAELQPQDQVLVVDATVAGEGSAGRNSGFLINLPHNTRMSGHHSPLEVARKQIAMLQSGLDWLAQLSGQGGFDCGWDLAGKYHAAATADGEQSLRGALQQYGQWGVAYSELDRDALQAQLGTRYYRFGYHSMNNVFVQPAALIRGLADSLPENVWLMEDNPVLSIDGSGPYKVRTRGGEFTADNVILANNAFARRLGFLRSRLVTIFTYAGVTPVLSPAQQALLGERDQWGVIPANRLGTTLRRISGGRFMVRSAYSYEAEQPLERMEQLLRDSFVRRYPDLAAHDFEYVWSGSTGLTGNGASFVGAIQPGLYASVGCNGAGVIKGTIYGKLLGEQVAGHRSAMLDDLASFEKPNWLPPEPLRRIGALSTIAYQARKAGLEK
>CP020645.1|AWP56541.1|89380_90172_+|ATP-binding-protein
MVAVNDPMISIEGISKSFGPFQALQGVDLKIPRGEFLVVLGASGCGKSTLLNLITGFERPTAGRIVVNGREVVDVDPHCGMVFQQYALFPWLTVAENVAFGLKMKGVAAASRRETAQQFIEMVGLKGFENAYPKALSGGMRQRVSIARVLANDPDVILLDEPFAALDAMTRQVLQEELTRIYEQSGKTIVFITHSIDEALLLSSRMVIMSARPGRVACDMPNDLPYPRNADVQLSPRYIELKSQIWDIVQNEVMRSLQARADQ
>CP020645.1|AWP56540.1|88622_89393_+|ABC-transporter-permease
MNAQNRQRRPDLLLISSVSVIVLLLFWEAVCRLQWVDALFLPPPSDVFARMGNMWEQGSLLDHIVASARRVMVGFAAATALAIPLGIFLGTSQRARAAFDPILSFLRPLPSMSWIPLSLLWFGITETQKYSIVFMGTFAPALLYVIEATRNIDPLLIRAARNLGASGPQVMRSVILPASLPQIFSGFKVILGLSWTCVISAELVAAKEGLGFLIMNGKEFFQTDTVVLGMALISVTVLVTDVVFRIIENRVLAWSR
>CP020645.1|AWP56539.1|87557_88559_+|taurine-ABC-transporter-substrate-binding-protein
MQETRRQFIKGMAIGAAALALPVAGRSWAAQAEAVRYGGSAWLGHYPAWLAIQAGYFKAENLEVGWESFGTTSARVSALLSGNIDMAVTAAPAALAVMSRGSRHFAIIGVPENFGRVEGLIVRSQVARLEDLKGKKVGVTFASSAHLLVLNLLDQAGLKAGKDVTVLNVPAPELPAAFQSGQIDAAAAWTPQFNAIRAMPDAKVLVDDTSFSLYKEYGVTPGPDVLVARRAFLDKNPEAVKRFLKAYFRANEQLKTQPDATVAALTELTKLSAADQLEMVKGADWYTAAEQGALLAPGSKYIDGLQKLAEMMVRYDQIDKAPPVREWVDAAYL
>CP020645.1|AWP56538.1|86560_87532_+|LysR-family-transcriptional-regulator
MGALKNDSSLDVRMLRIFAAVAAADSLSAAAQALNITQSAVSQTVTQIESILGMRVLDRTRRPYRLTPAGVALQRQSRQIVDDIDRLIAQVREADLMNRPAIRIGMIDSFAATTGPAIVKRLTQSASQVLVWSGLAYGHAQALLNRQVDIIVTTDALEDVDGLVRRPILNEPFVVVAPAVRADEFAPLDLRQMAQAAPFIRFSGRSHFGAMIERHLRRCGVTAPPFLEIDTSDVVMAMIAANLGWALMTPLCLLQGRSWLDQVVVLPLPGPSLARTLHQVSRLEEYQEMADMFWQLSRQALETEIFPQVTTQLPWLGRQMRLC
>CP020645.1|AWP56537.1|85585_86404_+|hypothetical-protein
MSIPTSRLAAVQAPPQDIAPQTLRDRMPAVLPVMDVVPATTDWPPFAVVDLLGATLLATGSERDVYQHPGNAALLIKIVNRARINEPGRRRPWHKKFHREDAHRVFITELIEYISTTVQLRQADGNTLLARIAGLALTSAGLGLVVEKIVDAEGKAAPTLAQVVSTQGFGPQLREQLRAFFLALIEAHVIFNDVSARNIVVGRNATGQDGLFLVDGFGPKQLLPLYAWSKTLNRRRLLRKYEDMVRKLARLGDRLARQAGQPLPGDGARPPR
>CP020645.1|AWP56536.1|84433_85579_+|glycosyltransferase-family-1-protein
MSQPHPLRIAHAEAAIGFGGQEQRILKEALAMRERGHHVELICRPQARLIERALDAGIRVHTVPMGGLRNFVRGVPRVRRILREGGFDVLNTHSRIDTLLAGAGARLAGTPLVVRTRHLSNRVNSMLSYTWIPHRVSTVSDHVRRYLIERGVSPAHIETIYSPINLPPPGLRSTLRDELGLPADAVVVACVAIMRATKGHRELIEALRPLMASRPQVHLVLVGNGSPLFEQLQALIAELGLSERIHMLGFRDDVPNVLAGSDIFALPTRKEASGTVFVEAAACGLPVVGVDVGGVSEMLRNGETGLLVPPDDAAALQGALRSLIDDASLRARMGGAGERMVRDEGKFSLARLAERTELVYRKWLAERRDAPTAVSRSARQS
>CP020645.1|AWP56535.1|83294_84281_+|hypothetical-protein
MKKLMQWGAALALAVTCGAAQAGDAVAAYPQRPVRLIVPYGAGGAADVLARIMAEKLSAIWKQPVIVENKPGGVGTIGIMATVQAEPDGYTLVSVPVSDLAVNPHLYRKRPFDVRKDLAPVSQVGAVPNVLLVSNALEVGDVQALVARAAAKPGYLTYSSPGVGSQAHIAAEMFAMRAGLSLQHIPYNSVPAALTDVAGGQIDMMFAQLPAVLPFVKSGRVKVLAVAADARTPLLPDLPTLGEVGGPSIGDAISWSAVMAPAGTPLALREKIAAGIASAIQSPQVREKLAAQGLIGLGGTPQQLEQAWRQDYERYGAAVKAMHIQLLD
>CP020645.1|AWP56534.1|81765_83256_+|ethylammeline-chlorohydrolase
MLTQIKGEWVLGFADGNHRMLRDASVVYEGERIVHVGTEFDGVADRVIDARGCLVAPGFIDTHVHSGHRALHKLLADGGRPDLFGQPYMDVTIARDGTRIKGYPNYLSREEAAVDPGIALHAAFTVAELLRNGVTTFVELGGHVMVQEALWRECERLGVRGYLGPGYDSGRWAADDQGRLRRVPYPDGGDHLFEEAVAFIKRVQAAGSDLVNGILVPREVENCSVDILRRTVQAAQELGVPMATHAGYNVIEFYETVREHRMTPIELLHSVGMLGPRLNIGHANLISDSPRLNYSGGRDLALMGEHRVSISHCPINIVRRARVLDSWKKYREAGVNLTIGSDTYPRDMVMNMRTASYHGKVMSHDLTAASAAEVFEAATLGGARSLGRTDIGRLEPGARADVIAINVGRQDVLRYGPIWDPIRSLVECGVGDDVELVVTNGQVRMEQGRIAGVDLGALRAEAQQFADNVWRDLQDWDPLRRTAQAMCPPSFCPDCM
>CP020645.1|AWP56533.1|80544_81486_-|LysR-family-transcriptional-regulator
MIAKHLDLNLLMIFDAILAEGHVTRAAERLAMSQSAVSKGLAQLRQAFGDPLFLRASRGVVPTHRALEIADQVRQAIAALNSLAGPVTEFDARSARAHFNIGATDYVSFVLLPGLMRRLQETAPHVSLTLHDMESMMPEEMLLAGKVDLVISSVASVNFPIYRQELFRDHYVCLCRAGHPALADPVPIEQFASSRHLAMPRQNGARERVLQDTLQRLGVTRDVAVQVPHMLAIPATLTATDLVATMACRVAREFAARHPLQVLAHPLPLPDFPVSQLWHDRTRRSPSHQWLRDTVYDLARVNACPAPQDSAPG
>CP020645.1|AWP56543.1|91716_91857_-|hypothetical-protein
MRKEEIMKMIAIGAGVMLLAGLVRACQGWRRLLRQLPDRNEDMTLF
>CP020645.1|AWP56544.1|91913_92558_-|TetR-family-transcriptional-regulator
MPGCHFSHDRAKLPGMSIPKSELTFAAIVDAALDMAAAQGMESLTLGEVAKRLGISKSGVFSRVGSREALLHAVLQEYDRRFLGAVFAPAMAAPRGLPRLDAMVGHWIERAANVEALTGCIYVAGAFEYDDVDNPMRGRVEANVRGWRAALGRTVRQAIDEGHLRPDTDPEQLVFEIYSLMVGLMHDARFLRDPRAHERVRQAYARLIATYRNT
>CP020645.1|AWP56545.1|92593_94771_-|malate-synthase-G
MTERIPHHGLQVAASLHRFIEDEALSGSGLAPDEFWAGFAALVRDLAPRNRELLAERDRLQGEIDAWHRAHPGPVRDSAGYQALLERIGYLQPQPAQVTASTRDVDSEIASQAGPQLVVPVSNARYALNAANARWGSLYDALYGTDAIPPVAGDDGKGYNPARGEAVIARARAFLDEAAPLAQGSHADATAYAIEGGKLAVTLGAGQRTGLRNPAQLAGYQGDASQPAAVLLANNGLHFEIQIDRQHQIGATDAAGVKDVLLEAALTTIMDCEDSVAAVDADDKVLIYRNWLGLMKGDLSESVTKGGKTFTRRLNADRQYHKPDGGTLTLHGRSLMFVRNVGHLMTNPAILDEQGSEVPEGILDAVITSLAALPDRANRLNSRTGSIYIVKPKMHGPAEAAFANELFDRVEDLLKLPRHTIKMGIMDEERRTSVNLKACIAAAAARVAFINTGFLDRTGDEMHTGMEAGPMLRKGDMKSSAWITAYERNNVLVGLDCGLRGRAQIGKGMWAMPDMMAAMLEQKIGHPKAGANTAWVPSPTAATLHAMHYHQVDVAAVQQALEQTRYDSVRDELLAGLLTVPVGDPAAWSADDIQRELDNNAQGILGYVVRWIDQGVGCSKVPDINNVGLMEDRATLRISSQHIANWLRHGIVDRAQVNATFERMAKVVDQQNAGDPNYLPMAGHFDTSFAYRAACALVFEGLTQPNGYTEPLLHEYRQAFKATRR
>CP020645.1|AWP56546.1|95014_95779_+|transcriptional-regulator-GlcC
MEPGVDGARKQIAEVVAERIERLILDGVLKAGQALPSERRLTEKLGVSRTALREGLRVLRARQIIHTAQGKGSYVAQISQVDAGPLVHLFNSQPRTLYDLLEVRALLESESARLAAIRGTDADFIMIRRRYDEMLAAHGRETDSATHAHLDHAFHLAICQASHNAVLVHTLQSLTDLLLGSVFACVNNLYHREPHKRHIDQQHERLFLAVLAREPEQAHQAARAHVDSVRQSLAEIEQEEQRLVRATLRLEGWV
>CP020645.1|AWP56547.1|95775_96903_-|saccharopine-dehydrogenase
MVRPPYPIAILGAGKIGAAIALLLQRGGDYDILVADQDPARLQAVARLGCRTAQVRDDDALQQAVSGRYAVLNALPFHRARAAAAACVRAGAHYFDLTEDVASTHAIRELAASAGTVLMPQCGLAPGFIGVVGSDLSRRFDRLLDLRMRVGALPRFPANALRYNLTWSTEGLINEYCNACEAIVDGALVAVPPMEGYETFTLDGIEYEAFNTSGGLGTLPQTLLGKARNVDYKSIRYPGHCAIMKLLLNDLRLRERRDLLQEILESAIPSTDQDVIVILASASGYRQQRLVQESFSARIYGATVDGQTLSAIQLSTAAGICTMLDLAVHGHLPQRGFIGQEQVPLAALLDNRYGRIYAGQPLPAREAPQALLPGS
>CP020645.1|AWP56548.1|97130_97517_-|hypothetical-protein
MKTLATAVILSMTMAAGAQAADLGAEPTRAQVQAELVQAKANGQYTFGEQDYPAAITQGSALSAAEVRDDLAQAKAAGEVTFGNLDYPPQASNVNSSMTRAQVQADLAQAKNDGVVTFGNLDYPPQHG
>CP020645.1|AWP56549.1|97782_98709_-|4-hydroxybenzoate-octaprenyltransferase
MSASQQQSVDLNDIVFTDWVERWLPRPWRPYARLCRLDRPIGTWLTLLPCIAALVQAAGGLPDLRRLLIFSLGALLMRGIGCTVNDMWDRDIDKHVERTRFRPLTSGQLSMRQAVAFLIGQLLVCASLLFFINDMSRWLAVAVLPFVFIYPFCKRVTYWPQVVLGICFNWGMLMAWSDTQDHLPLAAIAMWLGAVLWQVGYDSIYAYVDVRDDRSLGLHSTAMRFGEQGKLWIGGFYAATLALWTWGGYAMGLGWGYFAGIGAVAIHLAWQLREFDLQRPERNFKLFRANLWTGVLLIAAALAGTLPY
>CP020645.1|AWP56550.1|98795_99995_-|aminotransferase
MDKPFEPECSFSERAKQLTSSAIREILKVTERPEVISFAGGLPAPGGFPVEVVQAAFDKVLATNGRAALQYGPTEGYAPLRQWVADDLNAAGANVTADQILIVSGSQQALDLLGKVLIDKDSPILVEDPSYLGALQSFSLYQPKYVPIPTDDGGLVPEAITAELAEGARFLYALPNFQNPTGRTLNLERRKALVRQAAQFGVPIIEDDPYGELRYAGEPQPGLLALAGECGATVIRLGTFSKVLAPGLRLGYIAAPRNIINKLVQAKQATDLHTPTLTQMAVYEVVKTGFLAEHLPRVREIYRVQGRCMLEAIEREFPASVSWTKPEGGMFIWVTLPEHIDSTKLLAQAVEQNVAFVPGGPFYAGTPRQNTLRLSFATVPEAKIREGIAILGKLLKAAI
>CP020645.1|AWP56551.1|100133_100628_+|diguanylate-cyclase
MFDATPISTVSKPVFYAELAAQAHALLAGEHDRIANAANFSALVYRALPDINWAGFYFHDGQELVLGPFQGKPACVRIALSRGVCGAAASQRRTQVVPDVHAFPGHIACDAASRAEIVVPLVHKGSLLGVWDVDSPLPGRFDDEDRAGMEALCEVFLHSLGSAD
>CP020645.1|AWP56552.1|100915_101815_+|4-hydroxy-tetrahydrodipicolinate-synthase
MQYPAQSPFQGIWIPLVTPFADGAVDLPALRRLVRDYKAAGVDGLVACGSTGEAAALDEAEQLAVLDAVLEEAGALPVAMGLAGNHQGHVLRRLARLGERPLAGVLAPAPYYVRPSQAGAQAYFRALADASAAPLILYDIPYRTGAQLDTATLLALAEHPNIAAVKDCGGSVDKTLALIAHGGMAVLAGEDLQGLGTLCLGGTGMIAAAAHVRPDLFVAMHRAVRAQQLGQAQRLFLALAPVIRLLFAEPNPAPLKALLASQGRLRNEMRAPMLPAAEALTRRLQAELDVLDRAFAPGA

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Crispr_ID: CP020645_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_2

278291-278390

Orphan

Consensus_repeat	Method
GACAGGCACCTGCCGAATCCTGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_2

>merge|CP020645|2|278291-278390|CRISPRCasFinder
GACAGGCACCTGCCGAATCCTGGTCCTTCCCGCGAGGACAGGCACCTGCCGAATCCTGGGTGCCTGTCCCCCGCGGAGACAGGCACCTGCCGAATCCTGG

>CP020645|2|2|278291-278390|CRISPRCasFinder
GACAGGCACCTGCCGAATCCTGG	TCCTTCCCGCGAGGACAGGCACCTGCCGAATCCTGGGTGCCTGTCCCCCGCGGA
GACAGGCACCTGCCGAATCCTGG

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP56710.1\|275747_276569_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
CP020645.1\|AWP56715.1\|280265_281528_-\|ferredoxin-reductase	unknown	unknown	gnl\|CDD\|170080
CP020645.1\|AWP56704.1\|269847_271317_+\|potassium-transporter-Trk	unknown	unknown	gnl\|CDD\|182698
CP020645.1\|AWP56707.1\|273015_273666_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133025
CP020645.1\|AWP56706.1\|271937_272933_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224886
CP020645.1\|AWP56720.1\|286652_287840_+\|carbon-monoxide-dehydrogenase	unknown	unknown	gnl\|CDD\|224991
CP020645.1\|AWP56713.1\|278410_278926_-\|ring-hydroxylating-dioxygenase-subunit-beta	unknown	unknown	gnl\|CDD\|238357
CP020645.1\|AWP56703.1\|268419_269799_+\|Trk-system-potassium-transport-protein-TrkA	unknown	unknown	gnl\|CDD\|236541
CP020645.1\|AWP56709.1\|274977_275730_+\|maleate-isomerase	unknown	unknown	gnl\|CDD\|226004
CP020645.1\|AWP56708.1\|273989_274952_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|225070
CP020645.1\|AWP56712.1\|277643_278261_+\|N-carbamoylsarcosine-amidase	unknown	unknown	gnl\|CDD\|238497
CP020645.1\|AWP56705.1\|271396_271930_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
CP020645.1\|AWP56716.1\|281530_281842_-\|ferredoxin	unknown	unknown	gnl\|CDD\|239604
CP020645.1\|AWP56717.1\|282311_283415_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270400
CP020645.1\|AWP56714.1\|278940_280230_-\|biphenyl-2,3-dioxygenase	unknown	unknown	gnl\|CDD\|176889
CP020645.1\|AWP56719.1\|285819_286656_+\|carbon-monoxide-dehydrogenase	unknown	unknown	gnl\|CDD\|366378
CP020645.1\|AWP56722.1\|288899_289688_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224041
CP020645.1\|AWP56711.1\|276596_277628_+\|2,5-dihydroxypyridine-5,6-dioxygenase	unknown	unknown	gnl\|CDD\|225191
CP020645.1\|AWP56721.1\|287874_288903_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378117
CP020645.1\|AWP56718.1\|283444_285823_+\|carbon-monoxide-dehydrogenase	unknown	unknown	gnl\|CDD\|376913

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP56710.1\|275747_276569_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	6.48285e-19
CP020645.1\|AWP56715.1\|280265_281528_-\|ferredoxin-reductase	gnl\|CDD\|170080	PRK09754, PRK09754, phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional.	1.49145e-99
CP020645.1\|AWP56704.1\|269847_271317_+\|potassium-transporter-Trk	gnl\|CDD\|182698	PRK10750, PRK10750, Trk system potassium transporter TrkH.	4.1092e-135
CP020645.1\|AWP56707.1\|273015_273666_+\|hypothetical-protein	gnl\|CDD\|133025	cd04182, GT_2_like_f, GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.11169e-52
CP020645.1\|AWP56706.1\|271937_272933_-\|hypothetical-protein	gnl\|CDD\|224886	COG1975, XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones].	1.76773e-62
CP020645.1\|AWP56720.1\|286652_287840_+\|carbon-monoxide-dehydrogenase	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	2.86524e-60
CP020645.1\|AWP56713.1\|278410_278926_-\|ring-hydroxylating-dioxygenase-subunit-beta	gnl\|CDD\|238357	cd00667, ring_hydroxylating_dioxygenases_beta, Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the substrate by nonheme iron-containing dioxygenases. These enzymes consist of two or three soluble proteins that interact to form an electron-transport chain that transfers electrons from reduced nucleotides (NADH) via flavin and [2Fe-2S] redox centers to a terminal dioxygenase. Aromatic-ring-hydroxylating dioxygenases oxidize aromatic hydrocarbons and related compounds to cis-arene diols. These enzymes utilize a mononuclear non-heme iron center to catalyze the addition of dioxygen to their respective substrates. The active site of these enzymes however is in the alpha sub-unit. No functional role has been attributed to the beta sub-unit except for a structural role.	9.4455e-29
CP020645.1\|AWP56703.1\|268419_269799_+\|Trk-system-potassium-transport-protein-TrkA	gnl\|CDD\|236541	PRK09496, trkA, Trk system potassium transporter TrkA.	0
CP020645.1\|AWP56709.1\|274977_275730_+\|maleate-isomerase	gnl\|CDD\|226004	COG3473, COG3473, Maleate cis-trans isomerase [Secondary metabolites biosynthesis, transport, and catabolism].	1.92629e-83
CP020645.1\|AWP56708.1\|273989_274952_+\|amidohydrolase	gnl\|CDD\|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	1.78877e-56
CP020645.1\|AWP56712.1\|277643_278261_+\|N-carbamoylsarcosine-amidase	gnl\|CDD\|238497	cd01015, CSHase, N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.	3.44269e-78
CP020645.1\|AWP56705.1\|271396_271930_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	8.90133e-16
CP020645.1\|AWP56716.1\|281530_281842_-\|ferredoxin	gnl\|CDD\|239604	cd03528, Rieske_RO_ferredoxin, Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable microorganisms to tolerate and even exclusively utilize aromatic compounds for growth. ROs consist of two or three components: reductase, oxygenase, and ferredoxin (in some cases) components. The ferredoxin component contains either a plant-type or Rieske-type [2Fe-2S] cluster. The Rieske ferredoxin component in this family carries an electron from the RO reductase component to the terminal RO oxygenase component. BPDO degrades biphenyls and polychlorinated biphenyls. BPDO ferredoxin (BphF) has structural features consistent with a minimal and perhaps archetypical Rieske protein in that the insertions that give other Rieske proteins unique structural features are missing. CARDO catalyzes dihydroxylation at the C1 and C9a positions of carbazole. Rieske ferredoxins are found as subunits of membrane oxidase complexes, cis-dihydrodiol-forming aromatic dioxygenases, bacterial assimilatory nitrite reductases, and arsenite oxidase. Rieske ferredoxins are also found as soluble electron carriers in bacterial dioxygenase and monooxygenase complexes.	1.64156e-51
CP020645.1\|AWP56717.1\|282311_283415_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270400	cd13682, PBP2_TRAP_alpha-ketoacid, Substrate-binding component of an alpha-keto acid binding Tripartite ATP-independent Periplasmic transporter and related proteins; contains the type 2 periplasmic-binding protein fold. This subgroup includes TRAP transporters that bind to ketoacids such as pyruvate and alpha-ketobutyrate, xylulose, and other unknown ligands. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	0
CP020645.1\|AWP56714.1\|278940_280230_-\|biphenyl-2,3-dioxygenase	gnl\|CDD\|176889	cd08880, RHO_alpha_C_ahdA1c-like, C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins. C-terminal catalytic domain of the large subunit (ahdA1c) of the AhdA3A4A2cA1c salicylate 1-hydroxylase complex from Sphingomonas sp. strain P2, and related Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs, also known as aromatic ring hydroxylating dioxygenases). AhdA3A4A2cA1c is one of three known isofunctional salicylate 1-hydroxylase complexes in strain P2, involved in phenanthrene degradation, which catalyze the monooxygenation of salicylate, the metabolite of phenanthene degradation, to produce catechol. This complex prefers salicylate over other substituted salicylates; the other two salicylate 1-hydroxylases have different substrate preferences. RHOs utilize non-heme Fe(II) to catalyze the addition of hydroxyl groups to the aromatic ring, an initial step in the oxidative degradation of aromatic compounds. RHOs are composed of either two or three protein components, and are comprised of an electron transport chain (ETC) and an oxygenase. The ETC transfers reducing equivalents from the electron donor to the oxygenase component, which in turn transfers electrons to the oxygen molecules. The oxygenase components are oligomers, either (alpha)n or (alpha)n(beta)n. The alpha subunits are the catalytic components and have an N-terminal domain, which binds a Rieske-like 2Fe-2S cluster, and a C-terminal domain which binds the non-heme Fe(II). The Fe(II) is co-ordinated by conserved His and Asp residues. Other oxygenases belonging to this subgroup include the alpha subunits of anthranilate 1,2-dioxygenase from Burkholderia cepacia DBO1, a polycyclic aromatic hydrocarbon dioxygenase from Cycloclasticus sp. strain A5 (PhnA dioxygenase), salicylate-5-hydroxylase from Ralstonia sp. U2, ortho-halobenzoate 1,2-dioxygenase from Pseudomonas aeruginosa strain JB2, and the terephthalate 1,2-dioxygenase system from Delftia tsuruhatensis strain T7. This subfamily belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket.	7.36742e-125
CP020645.1\|AWP56719.1\|285819_286656_+\|carbon-monoxide-dehydrogenase	gnl\|CDD\|366378	pfam00941, FAD_binding_5, FAD binding domain in molybdopterin dehydrogenase.	1.61432e-57
CP020645.1\|AWP56722.1\|288899_289688_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	2.37649e-110
CP020645.1\|AWP56711.1\|276596_277628_+\|2,5-dihydroxypyridine-5,6-dioxygenase	gnl\|CDD\|225191	COG2309, AmpS, Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism].	4.74484e-07
CP020645.1\|AWP56721.1\|287874_288903_+\|hypothetical-protein	gnl\|CDD\|378117	pfam09084, NMT1, NMT1/THI5 like. This family contains the NMT1 and THI5 proteins. These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine. They are regulated by thiamine. The protein adopts a fold related to the periplasmic binding protein (PBP) family. Both pyridoxal-5'-phosphate (PLP) and an iron atom are bound to the protein suggesting numerous residues of the active site necessary for HMP-P biosynthesis. The yeast protein is a dimer and, although exceptionally using PLP as a substrate, has notable similarities with enzymes dependent on this molecule as a cofactor.	2.55416e-37
CP020645.1\|AWP56718.1\|283444_285823_+\|carbon-monoxide-dehydrogenase	gnl\|CDD\|376913	pfam02738, Ald_Xan_dh_C2, Molybdopterin-binding domain of aldehyde dehydrogenase.	4.36276e-180

>CP020645.1|AWP56712.1|277643_278261_+|N-carbamoylsarcosine-amidase
MSNDLGSYERQGFGAALPLKAPYGLLIVDFVNGFADPAQFGGGNIAGAIETTRTVLAAARERGWAVAHSRIVYADDDADGNIFSIKVPGMLTLKEHAPASAIVSQLAPQAGEYVVRKSTPSAFYGTMLAAWLAQRGVQTLLVAGATTSGCVRASVVDAMSAGFRPLVLSDCVGDRALGPHEANLFDMRQKYAAVMTHDEALAKTK
>CP020645.1|AWP56711.1|276596_277628_+|2,5-dihydroxypyridine-5,6-dioxygenase
MPVSDYEMIRAWTQVLRLSRLQAGQTVTVLTSAATHPQTLGTALVAAQSLGAVVNRLDLPPVNGEKALSRDALAYLGTTPLTGNKAAIAMLKASDLVLDLMTLLFSPEQHEILQGGTRILLAVEPPEVLARLVPTEEDRQRVKAAAGRIAGAREMTVESEAGTRLRCGLGEFPAISEYGYVDEPGRWDHWPSGFALTWPDEGSANGTIVIDRGDILLPQKSYVSEPIVLTVENGYATRIEGGLDAEMLREYVATFKDPQAYAISHIGWGLQPRASWTTLGLYDREATIGMDARAYEGNFLFSLGPNNEAGGSRTTACHIDIPLRRCTVRLDGREVVREGKVLD
>CP020645.1|AWP56710.1|275747_276569_+|alpha/beta-hydrolase
MSNFRYGGNVQANGIRQHYLRYGGERAGRDPVIIVPGITSPAVTWGFVGERFGEQFDTYILDVRGRGLSQSGPQLDYGLDAQAEDLLAFARALGLSRYSVVGHSMGARIGIRAARTGEAGLARLAMVDPPVSGPGRRAYPSKLPWYVDSMAQARQGMTGEQMKAYCPSWTAEQLQLRAEWLHTCEERAVIASFEGFHEDDVHADLPRVRAARLLMTAERGEVVLDADVAEIEALAPGTVHVRVAGAGHMIPWDNEEGFYAAFGDFLGARLRAG
>CP020645.1|AWP56709.1|274977_275730_+|maleate-isomerase
MQKTYRIGQIVPSSNTTMETEIPAMLLARQQIRGERFTFHSSRMRMKKVVKEELAAMDAESDRCAVELSDARVDVLGYACLVAIMAMGRGYHRQSQARLTAHTAANGGEAPVITSAGALVDALKVMGARKIAVVAPYMKPLTELVVDYIGNEGYEVVDYRALEIADNLEVGRHDAGRLPEIVAGLDYREADVIVLSACVQMPSLGAIAKVEAQTGKPVVTAAVATTYAMLKALGLEAVVPGAGALLSGAY
>CP020645.1|AWP56708.1|273989_274952_+|amidohydrolase
MTKVRKIAFEEHFTAVGFGDYSKAFVQHLDPGFAAELGARLTDFGAGRLAEMDAAGIDYAILSQTGPGVQGEPDAAVALRRARENNDFLAERIARHPDRFGGFATLPMHDPKTAAAELTRAVRELGFKGSLVNGHTNGVYYDDPAYDAFWEQMQELDVPLYLHPFDAYVLPHAYKGHPELAGATWGWGVETGTHALRLLFGGVFDRFPKLKIILGHMGEGLPFQRWRFDSRFAAYPYGVKLQRAPSEYIGSNILITTSGVCSHPTLVGAIAEMGAEAVMFSIDYPYESTALAVEFIESAPLDAATRDLVCYGNAARLFKL
>CP020645.1|AWP56707.1|273015_273666_+|hypothetical-protein
MPRVDHGSPQAGPPAPCVGILLAGGQGRRFAAASGGQDKLLARLADGTAVAVRAAAALREATDAVVAVVRPESAALAALLRGQGCHVLESEQAREGMGASLAAAARFLLAGPVPDMPERADVCLVALADMPWVRRDTLSAVRAAACADGITVPVHQGRRGHPVAFGRSLWGELAALRGDVGARELLRRHRVAAVEVDDPGVAADVDTPGDLAGDRA
>CP020645.1|AWP56706.1|271937_272933_-|hypothetical-protein
MNALDLDVLQHARDWLASGRRVHLVTVVQTWGSAPRQAGAMLAVRDDGQVVGSVSGGCIEDDLIARARAGTLPERAERLTYGVTRDEATRFGLPCGGTLRLVAEPLAPRDAWLDEVLQAIAEHRLVRRTIDLHTGAAALEAAAPAEGPDFDGRMFRAVYGPHWRLLIIGANQTAQVLADIAATLDFQVIVCDPREEFHAAWHAPHATLVTTMPDDTVLEIGTDERTAIVALTHDPKLDDMVLLEALKSRAFYVGALGSRANQEKRRERLRLFDLGDEDIARLRGPVGLPIASRTPAEIAVAVAAELVWVRNTLGDREPSGAPLPAALAPAR
>CP020645.1|AWP56705.1|271396_271930_+|MarR-family-transcriptional-regulator
MPEPDKQATRKKRTTSSLTDSTVFDPAKQVLWSRPGYLVRRLNQIHYALFYEECKTQNVTPVQYGVLTALSLSPWLDQTAIGMELGLDRTTTADVIKRLQERGLVERRVNPNDKRSRQAVITQEGLRIMGLLQGGMARAQQRLLEPLSPRNREIFMKLLSTLVDANNQYSRTALKAM
>CP020645.1|AWP56704.1|269847_271317_+|potassium-transporter-Trk
MKRLLATFYVLGLTMVVFALTMVIPLAVAYIGQDAGFTAFLEGFLLALGIGAGTWLATRRGRSELHARDGFLLVSTVWAALPALAAIPLLLYYDDVGIPLSFTDAYFEAMSGLTTTGATVLSGLDALPASINLWRATLIWIGGMGILVLAVAILPLLGVGGHQVVRAETPGPMKDERLTPRIASTAKALYAVYFGFSMVCLLAYRAVGLSWFDAWCHMATTMGLGGFSTYDDGFAHFDSLSVELVAIVFMTISGINFATHFNALRQRNWRAYVVCPQTIPYLTVMLGAGLVISVFLYIKGVYGDPWEALRYGMFNTISVATTTGYANVDYASWPLFAPLTMLLLSAFVTSAGSTGGGIKMIRIILLVKQARNELVTMLHPHAVSPVRIGSRVVDQRVMASVLAFMLVYGLSVGVLSSLLLLSGLDLITAFSAVMAMINNTGPGLGPLGPMGNFSVLNDFQTWVCTFAMLIGRLELLTVLVLFTPLFWRK
>CP020645.1|AWP56703.1|268419_269799_+|Trk-system-potassium-transport-protein-TrkA
MKILIMGAGRVGTSVAENLVSEQNDITVIDTDVGQLRYLQDRFDLRVVQGDGIQVSVLESAGADDTDLFIACAASDAANLVACKIAREVFNVPRRIARIRMPEFADHPELMSDEGFAIDALISPERSVTTYLHSLIEFPEALQVVEFAGGRVSVITVRVGHGSPMAHHPVDELREVWPDVTARIVDVLRDGRPLHAGTGTVVAPGDEVVLAVDTRHARRAVRQLREAEKTVHRVMIAGGGNIGLRLARQLAEEGYSVRIIEHDAKRCEYLAAELPDNVLVLHGNGTDEALLERENIEDMDTWLALTSDDEDNIMSSLLAKRLGARKVIALINRQAYGELMQGSHIDVAVSPSQATMSELLRHVRRGDVVAVHRLRQGVAEALEAVAHGDRSNSRVVGRAVGKIGLPKGASIGVLVRGDEIIVPDADTEIQSDDHVIVFVPSRRQMPRVEKLFQVSASFF
>CP020645.1|AWP56713.1|278410_278926_-|ring-hydroxylating-dioxygenase-subunit-beta
MSQTFFPPRTIDPARAIALKLEVEEFNADYCAALDGGQVESWPDFFTETALYRVTARENAELNLPVGLVYAEGRDMMHDRAVAISRTQMFAPRYMLHMVSNTRVTSETPDGEIAASSTFLLMQTLVEGPTTLHLAGSYHDRFVRENGTLKLQERQVIYDTAILANDLVYPV
>CP020645.1|AWP56714.1|278940_280230_-|biphenyl-2,3-dioxygenase
MYQSQTVIGRTLAAKDAPLSECAWPQDALHFIPDWVYTNNAVYEQELEKIFRGKTWNFVALEAELPNAGDYKRSYVGATPVVVSRAEDGSINVFENRCAHRGAEFCRHNQGNAKEFVCPYHQWSYDLKGNLQGIPFKRGVNREGGMPKDFKNDEHGLRRLHVTTRNGVVFASYSSEVEPIAEYLTPEILADFDAVFPGKKLKILGYYRNELPCNWKMYHENLKDPYHATLLHSFLVVFGLLVAGNKSAMLVDSVHGRHGTMASAKSEDKYATVSEENKKEMRSFHDGLRLRDDRFLEFIKEFDSPWSVTMQTIWPNLIVQREMNTLGVRHIIPNGPDSMIMQWTMFGYEDDTEEMQRHRLRQGNLMGPAGFLGLEDNEAMKFVQEGVRRASTDVNVIKLESGKQGTSNTLISEAAIRSMYSYYREVMGF
>CP020645.1|AWP56715.1|280265_281528_-|ferredoxin-reductase
MDEIQSIVIVGAGQAGAVAAASLRQLGYRGGLTLVGQEAHPPYERPPLSKAVLQGTATHAEAAVHPAGFYAENDIALLTETAVAALDPAARTVRLADGRTLPYDRCLLATGGHARELPALPRGRAGVHYIRTLDDALDLRAALRPGVRAAVIGGGFLGLEVASTARELGAEVTVIENGSRLLERALPAIVSDWLAERVRASGVDLRLGGAIAAIGDGPPYAITLADGTQVNADLIVVSIGLAPEVTLARQAGLPLDDNGGICVDSQARTADPQVYAAGDCASQPRACLGTAARFESWQNANEQARAAAAAMLGLAPAAEPYPWFWTDQYGCNIQILGLPQPGLRYVCRPQTDPQAAPRVLWIGLRDGVPCHGIAVNAGGDLRQLRVLFERGIPVDPHRLADPAEALKPLVKAWQAAVAVA
>CP020645.1|AWP56716.1|281530_281842_-|ferredoxin
MNWIKIATTDQLEDDEVMPVTAGEAKLALYRSEGEYFASDNVCTHAYALLSDGYLEDGCIECPLHQARFDIKTGKAMCAPATADIRIYPLKIENDDIYVDLQA
>CP020645.1|AWP56717.1|282311_283415_+|ABC-transporter-substrate-binding-protein
MQRRRFLAQAAGAAGAGLAAVGMPAMAQANPTVRWRMSTSWPKSLDTIYGSADELCKRVGQLTDGKFEIRAFPGGELVPSAQNMDAVSNGTVECNHVLSTMYIGKNTALTFDTGLSFGLNARQHNAWIHYGGGLQQLRELYKKYNIVNHVCGNVGVQMGGWYRKEIKSTADLNGLNMRIGGIGGMVLSKLGVVPQQIPPGDIYPALEKGTIDAAEWIGPYDDEKLGFNKVAPYYYSPGWFEGSASITSMVNDKAWEALPPAYQAAFEAACGEQSMRMLANYDARNPLALRKLIAGGAKVSFFPKEVMDAVYKASQQLWTELSEKNPDFKAIYPGWKKFQEDEAGWFRVAENALDNYTFAAVARAQAK
>CP020645.1|AWP56718.1|283444_285823_+|carbon-monoxide-dehydrogenase
MTTEHTGAEVGAGSRQGVGARVPRKEDARHLHGKGNFVADMAMPGLCEVAFLRSPLAHARITDVRVPESVRDKVVLRSIMGDARDIAADSTLPTYQPSVQPPLASGKVRFVGEPVAMTFAPTRAEAEDHAELVEVDYDDLPVYADVASAQQATSDLVHEHWRDNVFVTLNADRDFDEHAARAEVVVKRKIDLARQCMVPMEGKAVLAYWDHQADQLVVISATQVPHMIRSVLAQCLDLEQGRVRVVSPDVGGAFGYKCVLQQEELCVAWLAKTYKRPFRFIEDRREHLTAGANSREHHYEMTAYADKRGKLLALDARITIDGGAYSVWPFTIGLEPGQAVGNLPGPYGFRGYRCETRCVATNKPGFVPYRGVARTGVCFAIELTMDAVAREVGREPWEVRLENLVQPEQMPYVNVTNKHFDSGDYPASLRKALEMIDIDGVRTRQARGEADGRRIGVGVATYTEQAAHGTSVFAAWGTPVIPGFDQATVRVTPDGGLEVRVGVHSHGQGMETTFAQIAHEILGIDVARIKVLHGDTGQTPFSTGTYASRSLVMSGGAVSQACKRLLPRMRHIAAHMLGVADDAVTLQDGIYRAGEKAVATGDVADAWYLRPQLLPPDVDPAGLEVNVGYKPKVDTGCFTYASHAAVVAVDPDTGAVEILDYVVVEDCGTMINPMVVEGQTIGGIAQGIGTAFYEETPYDANGQPLASTLADYMLPGPTEVPNMRLHHFETPSPHTEFGAKGMGEGGAIAPPAVLFNAVNDALRGLGAAELSRTPLTPIRVLQAIAQGAGEAA
>CP020645.1|AWP56719.1|285819_286656_+|carbon-monoxide-dehydrogenase
MKAAQFEYFRAESTQQALQWLRQHDGRAKLMAGGQSLGPMLNLRLARPPVVIDISGVPALREVGERGGRVRVGAAVTHAEIEDGVHAALRGSALQQVATGIAYRAIRNRGTVGGSLAHADPAADWVLTMVALGADIEIAGVDGERMVPAESFMQGAYTTVVGEGELIAAVHVPAMTDGARWGYYKFCRKTGEFAEASCAAWFEPARRVARIAVGALDGAPCLLPGLADAVARQGAAALQAERIDEAVAQAMPGKDALHRKLHATAVARCLKQALGVQE
>CP020645.1|AWP56720.1|286652_287840_+|carbon-monoxide-dehydrogenase
MTMVQVTLEVNGRQVAHEAPPRMHLGDFLRDQARLTGTHLGCEHGVCGACTVLVDGQPVRSCITYAVACEGRQVTTIEGYDGDPVMARLRAAFTKYHALQCGYCTPGMLTTSRDIVLRLPDADEARVRVELSGNLCRCTGYMGIVGAVMSVLRDLREQPDAAVQALRAAAADGRLPAPRGEQPVAFQPFTPSAPAPAQAAPRPAAAASPAGGKGNQIVDAFTVPFPAAEVWAFMVDLPAVAACLPGAVIEETDGQRVKGKIAIKFGPMAAAFNGAARLERDEAAMRAVFRGAGQDSLSQSRATGDIAYQVEAVSENETRVKVDLQYALQGPLAQFSRSGLVQDFVRRMIADFGKNVTARLRQPGGEALPQAQFNPVAMFFSVLWMRVKRWFGRGG
>CP020645.1|AWP56721.1|287874_288903_+|hypothetical-protein
MEMQKAIGKWWRRAMGGIALLAAAGTAGAQAPEPLRVRLDWTPWGVQAAFHLAQQKGWYKQAGLDVTLEDGNGSVTTVQIVGGSDRFDLGHAALASMMIARDKGLPVKAVAVFARHSDIGLLVPADSGIAGPEQLKGRKVAYTAGSLEAPFIDAFLARGKLKKSDLELINVDAASKASTYAVGRADAAFSTIPFFLPVVSQNRPSRAVRFADFGLDMPSFGLFASEDKLRERGEAIGRFASVSARAWEYIYAGHEDEAVSAILAQRPQARLDRTVLRGQIDALRGYFGLAAGQRVGAPVPADWELAVKTLSSVGLVRADARAADFYVPDLARPQRYDALVKP
>CP020645.1|AWP56722.1|288899_289688_+|ABC-transporter-ATP-binding-protein
MSVAAVSAAGVRKKYPGERGVQALETISIDVPAGRFVSILGPSGCGKSTFLRCVAGLETISEGELRVAGQPVKGPPDGIGMVFQRDALLEWRNIRRNILLPVEFAGKPVARYRDKVDALLRLTGLTAFADNYPRELSGGMRQRAAICRALVDDPALLLMDEPFGALDALTRDQMNVELQRIWMETRNTVMFVTHGIAEAVFLGDEVMVFSPRPGRVLETIRIDLPRPRPLAVRETAEFGRYVRHIRGLFEQMGLIDEGGRAP

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Crispr_ID: CP020645_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_3

693193-693313

Orphan

Consensus_repeat	Method
CGGGACAGGCACCAGCAGGTGCGGGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_3

>merge|CP020645|3|693193-693313|CRISPRCasFinder
GGGGACAGGCACCCGCACGGGCAGGCGCCAGTCCTCATGCGGGACAGGCACCAGCAGGTGCGGGCGCTGGCGTGGCTCCCGGTGCCTGTCCCCACGGGACAGGCACCCGCAGGTGCGGGCG

>CP020645|3|3|693193-693313|CRISPRCasFinder
GGGGACAGGCACCCGCACGGGCAGGCG	CCAGTCCTCATGCGGGACAGGCACCAGCAGGTGCGGGCGCTGGCGTGGCTCCCGGTGCCTGTCCCCA
CGGGACAGGCACCCGCAGGTGCGGGCG

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP57059.1\|684441_685971_+\|aldehyde-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|143448
CP020645.1\|AWP57058.1\|683529_684228_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224715
CP020645.1\|AWP57065.1\|691980_692271_+\|hypothetical-protein	unknown	unknown	unknown
CP020645.1\|AWP57066.1\|692360_693104_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
CP020645.1\|AWP57061.1\|687834_688794_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270234
CP020645.1\|AWP57069.1\|695786_696617_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270431
CP020645.1\|AWP57067.1\|693575_694466_+\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
CP020645.1\|AWP57062.1\|688818_689931_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227601
CP020645.1\|AWP57072.1\|698039_699278_+\|amidohydrolase	unknown	unknown	gnl\|CDD\|349916
CP020645.1\|AWP61070.1\|687181_687532_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|100007
CP020645.1\|AWP57063.1\|689945_690980_+\|GTP-binding-protein	unknown	unknown	gnl\|CDD\|223597
CP020645.1\|AWP57074.1\|700185_701448_+\|Zn-dependent-hydrolase	unknown	unknown	gnl\|CDD\|184168
CP020645.1\|AWP57073.1\|699350_700148_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|131484
CP020645.1\|AWP57064.1\|690976_691978_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238121
CP020645.1\|AWP57071.1\|697260_698043_+\|ectoine/hydroxyectoine-ABC-transporter-ATP-binding-protein-EhuA	unknown	unknown	gnl\|CDD\|224051
CP020645.1\|AWP57068.1\|694466_695702_+\|aspartate-aminotransferase	unknown	unknown	gnl\|CDD\|235596
CP020645.1\|AWP57075.1\|701453_702728_-\|amidase	unknown	unknown	gnl\|CDD\|223232
CP020645.1\|AWP57076.1\|702736_703663_-\|chitin-deacetylase	unknown	unknown	gnl\|CDD\|200599
CP020645.1\|AWP57070.1\|696613_697264_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
CP020645.1\|AWP57060.1\|685987_687151_+\|cystathionine-beta-lyase	unknown	unknown	gnl\|CDD\|181615

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP57059.1\|684441_685971_+\|aldehyde-dehydrogenase-family-protein	gnl\|CDD\|143448	cd07130, ALDH_F7_AASADH, NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B. Alpha-aminoadipic semialdehyde dehydrogenase (AASADH, EC=1.2.1.31), also known as ALDH7A1, Antiquitin-1, ALDH7B, or delta-1-piperideine-6-carboxylate dehydrogenase (P6CDH), is a NAD+-dependent ALDH. Human ALDH7A1 is involved in the pipecolic acid pathway of lysine catabolism, catalyzing the oxidation of alpha-aminoadipic semialdehyde to alpha-aminoadipate. Arabidopsis thaliana ALDH7B4 appears to be an osmotic-stress-inducible ALDH gene encoding a turgor-responsive or stress-inducible ALDH. The Streptomyces clavuligerus P6CDH appears to be involved in cephamycin biosynthesis, catalyzing the second stage of the two-step conversion of lysine to alpha-aminoadipic acid. The ALDH7A1 enzyme and others in this group have been observed as tetramers, yet the bacterial P6CDH enzyme has been reported as a monomer.	0
CP020645.1\|AWP57058.1\|683529_684228_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	8.1478e-40
CP020645.1\|AWP57061.1\|687834_688794_+\|hypothetical-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.47742e-92
CP020645.1\|AWP57066.1\|692360_693104_+\|transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.15476e-76
CP020645.1\|AWP57069.1\|695786_696617_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270431	cd13713, PBP2_Cystine_like_1, Substrate binding domain of putative ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This group contains uncharacterized periplasmic cystine-binding domain of ATP-binding cassette (ABC) transporters. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.07516e-107
CP020645.1\|AWP57067.1\|693575_694466_+\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	5.52693e-93
CP020645.1\|AWP57062.1\|688818_689931_+\|hypothetical-protein	gnl\|CDD\|227601	COG5276, COG5276, Uncharacterized conserved protein [Function unknown].	2.68222e-28
CP020645.1\|AWP57072.1\|698039_699278_+\|amidohydrolase	gnl\|CDD\|349916	cd05666, M20_Acy1-like, M20 Peptidase aminoacylase 1 subfamily. Peptidase M20 family, uncharacterized subfamily of bacterial proteins predicted as putative amidohydrolases or hippurate hydrolases. These are a class of zinc binding homodimeric enzymes involved in hydrolysis of N-acetylated proteins. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity. Aminoacylase 1 (ACY1) breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine).	0
CP020645.1\|AWP61070.1\|687181_687532_+\|hypothetical-protein	gnl\|CDD\|100007	cd06150, YjgF_YER057c_UK114_like_2, This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	5.19285e-55
CP020645.1\|AWP57063.1\|689945_690980_+\|GTP-binding-protein	gnl\|CDD\|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	2.17308e-124
CP020645.1\|AWP57074.1\|700185_701448_+\|Zn-dependent-hydrolase	gnl\|CDD\|184168	PRK13590, PRK13590, putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional.	1.72641e-169
CP020645.1\|AWP57073.1\|699350_700148_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|131484	TIGR02431, p-hydroxybenzoate_hydroxylase_transcriptional, beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family. Member of this family are IclR-type transcriptional regulators with similar DNA binding sites, able to bind at least three different metabolites related to protocatechuate metabolism. Beta-ketoadipate is the inducer for PcaR, p-hydroxybenzoate for PobR, and protocatechuate for PcaU. [Regulatory functions, DNA interactions].	1.02062e-47
CP020645.1\|AWP57064.1\|690976_691978_+\|hypothetical-protein	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	4.66666e-14
CP020645.1\|AWP57071.1\|697260_698043_+\|ectoine/hydroxyectoine-ABC-transporter-ATP-binding-protein-EhuA	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.24747e-140
CP020645.1\|AWP57068.1\|694466_695702_+\|aspartate-aminotransferase	gnl\|CDD\|235596	PRK05764, PRK05764, aspartate aminotransferase; Provisional.	1.35686e-174
CP020645.1\|AWP57075.1\|701453_702728_-\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	3.4702e-100
CP020645.1\|AWP57076.1\|702736_703663_-\|chitin-deacetylase	gnl\|CDD\|200599	cd10977, CE4_PuuE_SpCDA1, Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins. Allantoinase (EC 3.5.2.5) can hydrolyze allantoin((2,5-dioxoimidazolidin-4-yl)urea), one of the most important nitrogen carrier for some plants, soil animals, and microorganisms, to allantoate. DAL1 gene from Saccharomyces cerevisiae encodes an allantoinase. However, some organisms possess allantoinase activity but lack DAL1 allantoinase. In those organisms, a defective allantoinase gene, named puuE (purine utilization E), encodes an allantoinase that specifically catalyzes the hydrolysis of (S)-allantoin into allantoic acid. PuuE allantoinase is related to polysaccharide deacetylase (DCA), one member of the carbohydrate esterase 4 (CE4) superfamily, that removes N-linked or O-linked acetyl groups of cell wall polysaccharides, and lacks sequence similarity with the known DAL1 allantoinase that belongs to the amidohydrolase superfamily. PuuE allantoinase functions as a homotetramer. Its monomer is composed of a 7-stranded barrel with detectable sequence similarity to the 6-stranded barrel NodB homology domain of DCAs. It appears to be metal-independent and acts on a small substrate molecule, which is distinct from the common features of DCAs that are normally metal ion dependent and recognize multimeric substrates. This family also includes a chitin deacetylase 1 (SpCDA1) encoded by the Schizosaccharomyces pombe cda1 gene. Although the general function of chitin deacetylase (CDA) is the synthesis of chitosan from chitin, a polymer of N-acetyl glucosamine, to build up the proper ascospore wall, the actual function of SpCDA1 might involve allantoin hydrolysis. It is likely orthologous to PuuE allantoinase, whereas it is more distantly related to the CDAs found in other fungi, such as Saccharomyces cerevisiae and Mucor rouxii. Those CDAs are similar with rizobial NodB protein and are not included in this family.	1.63802e-161
CP020645.1\|AWP57070.1\|696613_697264_+\|ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	9.06277e-72
CP020645.1\|AWP57060.1\|685987_687151_+\|cystathionine-beta-lyase	gnl\|CDD\|181615	PRK09028, PRK09028, cystathionine beta-lyase; Provisional.	1.88042e-149

>CP020645.1|AWP57066.1|692360_693104_+|transcriptional-regulator
MGKTLVKGLHLLERLAASPEPMGITELAADLDLVQSNVHRLLQTLMESGYVQQDALTRRYRCTMRLWEMGTQIADRMDLSRIARPHMQALVKQSQETVHLAILDGADVLYIDKIDSPQPVRSYTRVGGRAPAYCTGTGKMLLAYCDDLAAALPAKLVKHTARSIASHAALKAELRRVREEGFSENAGEWREDVYGMGAPLFDATGKVSAAIGISGPLARMDAAVVARVRPMLQETARIISRELGYRG
>CP020645.1|AWP57065.1|691980_692271_+|hypothetical-protein
MCAEVDYEDRGTYRKVPPPSEALIERTRQVEAGMPGERVPEQAWGTFFAVSCGVMDMGSFQRMFEARRIALSYLAMQRARYARRHGGGTGLRCIGD
>CP020645.1|AWP57064.1|690976_691978_+|hypothetical-protein
MKMLNRLDLGVPCLRAGFAGEQAFFLAMDGRLHVQQGDQRRVVALHDGDVLSACAAPGQADAAAWLLSAGEDGRVMRAGAGEPDCVASVPNKWVTALAVAADGALAYASGRTVWLAGGGGEAAALPQERPVQALRFSHGGRWLAVAGYDGLALYDRQAGGEPQRLDWKGMPTRVAFSPDDRFVLVATRDAVLHGWRLDTLRHFRMVGYPRAVGSWSWLAGGQWLATDGSAGAVLWPFEGEEGPIGSTPLALGERPDGEVSAVACHPARPWVAVGYADGLMVLESTDGALRRILGQAGRDRVACLAWDRAGARLAYGTPSGACGVIQADMGEEG
>CP020645.1|AWP57063.1|689945_690980_+|GTP-binding-protein
MSEATRKVPVTVLTGHLGAGKTTLLNRILTGQHGRKYAVIVNEFGEIGIDNDLIVESDEEIYEMNNGCICCTVRGDLIGILHKLLRRPGRFDAIVVETTGVADPAPVVQTFMMDEEVREKTELDAVITMVDAKHFPLRLADSQEAEDQIVYADVVLINKVDLVSDGEADQVQRRVAAINPYAACHRVQRAEIDLARILSIGAFDLQRCVELEARAAPAGCGHEHEHEHEHDEHCHGGTDHHHHHHEISVMSVSLQAGALDGRRFFPWIHSLVEKQGPDILRMKGILALDDDARRYIIQGVHMIVEGEHQRAWRDDEPRASKLVFIGRGLDAQALRAGFEACRSQ
>CP020645.1|AWP57062.1|688818_689931_+|hypothetical-protein
MASIKGLREVAYFDCAGGGQVYVQGNYAYIAHMDAPAGTTIVDISDPRHPRQVAHIPIPDGVHTHKVRVENDLMLVNWECPPPYILGENFQGGLAIYDVSDPTNPRQICFWKTAGTGVHRFDFDGRHAYITPEVEGYHLNIAMILDLENPAKPREVGRWWMPGQWVAGGETPDEGYRMTWCHQVLRRGNRLYVAYWHGGMVILDIEDMSKPKLVSKFAYSPTFAHPTHTVLPLPFELAGRKIAIVADEDVRKVRPSPPPFMWLFDITDETQPVPISTYQIEELMDKNMPEFTGCHQPAEQVYGTEIPVAWFAKGLRVVDVKNPHAPREVAHFEPDIPGFDRAQTNDVFLTKEGLMYIIDRNRGMHILERI
>CP020645.1|AWP57061.1|687834_688794_+|hypothetical-protein
MKKLIVAALFAVLPSMVGAQQAPRGTMTIVNPFTVSGLTDLVARMVAEKAHAKFPDGVAVVSRPGGGGSIGIASVVNARPDGSSIGFTPTGAVVDAPQMMKGLAYKTPDDIDPIINVFSSYQMLAVRGDADWKTAQDFIKAVRQSPGKYSLGHTGNGTASHLNMAQLVQAAKLNVLEVPYKGWAQSSVALLGGHVDAIVINAGEGRALVDEGRLRILGVFQAQRVPYHPDVPTFKEIGYDVGVGLKFFFFGPKNMDAGVKQYIHDAFKQAMQNDDFKKFIASREVEVDYMDGAQTKAMLWSEYKQHTKLLDSLGLLAKQ
>CP020645.1|AWP61070.1|687181_687532_+|hypothetical-protein
MSDIQYVETSPRYSKAVIHGDTVYLAGQVADDPGGTVQDQMRQILAQIDALLARCGTDKSRLLSAMVLLKDMRDLEAINPLWDAWVVPGRAPTRTPSEARLALPGYLVEVQVTAAR
>CP020645.1|AWP57060.1|685987_687151_+|cystathionine-beta-lyase
MKPDTRLVHLGRDPERFEGLVNIPPCRTSTFLHASVADYQAAASRKQDSLYYGRFGSQTSRALEAACTELDGGHGAMLFPCGLAAITRVLGSLLEPGQHLLMADTVYGPARAFCEQELARLGVETTWYAPDADLDALVRPATRVIYGEAPGSLTFEMQDLRALAEVARRHGLVSVVDNTWATSWFCQPLALGIDISIQSASKYIVGHSDAMLGVAVANEAQFPALRRAAAQYGNAVSPDDCYMALRGLRTLGVRLERHQASALRVAQWLRTRAEVEQVLHPALPDSPGHALWRRDFSGASGLFGVAFRAGDDAALARFVDDLRLFGIGVSWGGFESLALPSHPVRNTSAAALGGRPLVRLHIGLEDPDDLIADLARALDRHMAAARG
>CP020645.1|AWP57059.1|684441_685971_+|aldehyde-dehydrogenase-family-protein
MTTVHCATPEETRRLLQQLGVDPARYDGGTLEVRSPIDGQAIARLPELTAEQARARVADARQAFLAWRKVPAPRRGELVRLLGEELRAAKAELGRLVSIETGKILSEGEGEVQEMIDICDFATGLSRQLYGLTIATERAEHRMMETWHPAGPVAIISAFNFPVAVWAWNAAIALVCGDSLLWKPSEKAPLTALATQALLERALARFGDAPAHLSQVLIGGREVGEALVDDARIPIVSATGSTAMGRKVGPKVAERFGRSILELGGNNAAIICPSANLDLALRGIAFSAMGTAGQRCTSLRRIFVHEQIADDLVARLKQVYESVAIGDPRDSGTLIGPLRDQAAFDAMQRSLADARAAGGRVTGGAREPVGGHDQAYYARPALVEMPAQSEVVERETFAPILYVMRYRDLDEAIALQNDVPQGLSSSIFTNDLREAERFVSAEGSDCGIANVNIGPSGAEIGGAFGGEKETGGGREAGSDSWKAYMRRTTNTVNYGNALPLAQGVKFDVA
>CP020645.1|AWP57058.1|683529_684228_-|GntR-family-transcriptional-regulator
MRMMEPDEPHDGATDDKASMPLRRQAEDALRKTILSGRFMPGERLKERELMELLNASRTLVREALRQVEAEGLIEIVPNRGPVVAVLSYEEAEEIYEVRGILEAQTCTGFALRAGSGHMKTLAAAFDALSEAARQGDIPRTLALSDTFYDTIAAGCGNRLLGNMLRQLHNRIVLLRRTSLSEPSRLPETLYELTQIFEALKARDEIAAGKAALHHVRQASRTALQVLRSRQS
>CP020645.1|AWP57067.1|693575_694466_+|dihydrodipicolinate-synthase-family-protein
MLISARTLRGIITATPTPFTREGGVDREVLRSHIEFLIGRGAAGLAPLGGTGEYPALSARERADVVRWTVEAARGRVPVVAGVLATGYEDAVQAGLAAREAGADALMVVTPYYALAGDAGVRAYFERYSAAVDLPIVLYEIPRRTNVELRAETIAAMAGDGTIVGIKYSGSDFAKLTRLIHLAGDTLAVLSGEEPLFPAAVALGAVGGVLAMSNLDPAPWARIQSLVEAGEMAQALQLHHRQGALADAVYSEMNPVGLKAALQLKGFAFGEARLPLQPAGPQTLLRLQQAFEALES
>CP020645.1|AWP57068.1|694466_695702_+|aspartate-aminotransferase
MNTISDSAAVAAGRRVAARMARVTTSKIYLAIAKVADMQAQGMQVASLTAGEPDFDTPAHVIEAAVQAMRGGDTHYTPVRGSLAMREAVRQKFQRENGLAFRDEEVMVGTGSKQVIANALAVTLETGDEVLLPVPYWAAYTGMVYAAGGVPTFVGTRAEDGYKLTPQALRAALGPRTRWVILNTPSNPSGLVYGSDELRALGEVLRERPDVLILTDEIYEHLNYTAEPPASLRKLCPDLAERIVVVNGVSKAYAMTGWRLGFAGGPADIIEAMANLQAQTTLAPCSISQAAAVAALNGPRESIDAMAAAYRRRRDLVMQIAGGQPGVRLQRPDGAFYAMLDLSEALAGGERFRGDPEPDQAFCEWLLETRHVAAVPGSVFGAPGSVRISFATDEQTIERGLTGLLDAAAHC
>CP020645.1|AWP57069.1|695786_696617_+|ABC-transporter-substrate-binding-protein
MNAVIRKMPAMLKWLMAVPLALGLAHAHAETVLEKARAKNEIRIATSDSLKPWGYMDDTNKPIGFNLDVSREMGKRMGFGKVTFVTDSYKNFISGLNADRYDMVVAILTPTEERRKSADFSNPYMVVSKNIFVRDDNTSIRSLEDLAGKRLGVAAGTTDEAWARQHVKDAQIRVYDNFFLALQDLAIGRVDARITDRVTGMTAAKEGRFPVKIAGPDLSQDIGAIAYKKGQDDLAAVVNKVIQEMVDDGSLNEISRKWLAGIEMGEELKKLPKDAR
>CP020645.1|AWP57070.1|696613_697264_+|ABC-transporter-permease
MIELLHKAAPIIQGALLMTLLLGLSAAVLGTALGLVLALFRLSPVAPLRWLAFWYVSIFRGTPLLLQLLLIYFGLPHYGIELEPVPTAILALSLCSAAYLSENFRSGILGVDRGQIEAAQSLGMGAARSLFRIILPQAIRIAAPTMGTRYIALMKDTSLASTITVVELTKMAEQVGSNTFRYMEMFIIAGALYWVINQMLTFIQVWVESKLGKGVA
>CP020645.1|AWP57071.1|697260_698043_+|ectoine/hydroxyectoine-ABC-transporter-ATP-binding-protein-EhuA
MMQHDQAAGSPVVQVEGLRKSFGANTVLKGVDLTIRRGEVVVVMGPSGSGKTTFIRSLNFLEVPDEGAITICGTRVAVQAGAGLKREQRRRVREIRQKTAMVFQSFNLFSHMTVIKNIIEGPVQVKGAARDQAIEQARALLRQVGLAEKENEYPSRLSGGQKQRVAIARALAMKPEVIFFDEPTSALDPELRDEVLSVMRKLADEGMTMVVVTHEVRFARDVADRVIFMEGGVVLEDAPSASFFDAPASERIRQFLRRVQ
>CP020645.1|AWP57072.1|698039_699278_+|amidohydrolase
MTGGARPGWAADPLVEAVGRETGELMRGIRHDLHAYPELSFEEHRTAGRVRACLQEWGIPVLDGLGETAVVGVLRAGDGGQAIGLRADMDALPIHETNTFGHASRHAGRMHACGHDGHTAMLLGAARYLQRHPDFDGTIYLIFQPAEENGRGARAMIEAGLFRDHPMQAVFGLHNWPGLAAGKFALTAGPIMASSSRVKVTYTGKGGHAALPEQAIDPVAAVAALHQALQTVVTRNTAAHDSVVLSITQLGGSDNHCVIPDQAWLAGSLRTLSPAVLERTCARIRDIAQGVAAAFSCAARIEIEHAVPATINDAGATALCRDAIAQWLGPKWLNDGFIPTMGAEDFAFMLQALPGCYLMLGNGGGREGETATVCGLHNPGYDFNDEIAAVGAAYWVRLAGHCLPRGGAGPLA
>CP020645.1|AWP57073.1|699350_700148_+|IclR-family-transcriptional-regulator
MASKKAAGEADKDHLFVNSVAKAFRLLEAFDKSRPMSGFSQAAREIGMEKSAAQRAAHTLWRLGYLDKVGRDGEYRLSRRCLDIGQRYLETNRLVVCTNPYLKFLRRKTNASVNLAMLDGTDTVFPVRYTSQEMLNNDLGERARIPAYCTATGIAIFSAMPDEAVREVLERSDLKPLMPNSIWQMDRIMERVESARRDGYVLGVEEDFASDITIACPISDPATGDVAAIGVSYSSEVTAVEQVVQDWCPLVMSTAREVTARLAER
>CP020645.1|AWP57074.1|700185_701448_+|Zn-dependent-hydrolase
MTAAFASLGQTIVDQAARLASHSDMEGGLTCAYLTPAHRATQAQLAQWMEAAGMAVRIDAIGNVIGRYAADPAVAAPRVLMTGSHFDTVRDGGRYDGRLGILLPVAVAGALRDAGVRLPYHLDVVAFAEEEGLRFKTSFLASGVLAGSFDPALLARQDADGVTLAQALAASGLPGAGDPAALRAAALDPATLLGFVEVHIEQGPVLLHHGLPLGVVTQIAGSSRFMARVEGMAGHAGTTPMNLRQDAGAAAAEMVLLVESRCSQVPTLVGTVGQLQVPNGSGNVIPGACQFSIDIRAAEDPVREAAVADVRAGIEQIARRRGVRVSLDAVPPVGSVPCARWLMDQFGAALSEAGLAVHELPSGAGHDAMVMQRIADVAMLFVRCGNGGVSHNPLETLSAEDAQQAAEVFAAFLRRFAPRG
>CP020645.1|AWP57075.1|701453_702728_-|amidase
MQPLHLLGLDEARERLVAGACDSVDLVQACLDRIAAREEQVRAWAWVDAEGALRKARAMAGARPDPRRPLAGLPIAVKDIIDTADMPTAYGSPIYAGHRPAWSAYCVAAIEAAGGIILGKTATSEFAHSAPPATRNPHAPAHTPGGSSGGSAACVADFMAPAALATQTGGSTIRPAAFCGVVGYKPSLGLIDRTGVKPMAESLDTVGLMARAVADIQLLAGVLAGVPASTPGSAAPRIGLYRTPHWERIDAPSRDALLARLRRLERHGARVAEVPDLPALHPLYQDQRDIMNHQAARALLHEYRQHREQLSPALRAALEAGQACSPDALRAAWQRTRRARRAYAELWADYDLIVTPAALGAAPAGIASSGDSLLNRNWSLLGVPALSLPNGADPRGLPLAMQLAGSHGGDAALLGWARWIEAAA
>CP020645.1|AWP57076.1|702736_703663_-|chitin-deacetylase
MTMQTDRSLLTRRDFVGYGSTPPDPQWPGQARLALNIVVNYEEGSEASFEDGDGRSELGLTEVTGSSFQGRDLAAESMFEYGSRVGIWRVLRLLRERGMTATFFACAQALERNPAVAQAIREGGYDVCCHGWRWTPLQALSEAQEREEMQRAVASIERTIGQAPAGWYCRYAPTVNTRKLVLEQGGFLYDSDSYNDELPYWVDAGDRHHLVIPYTQAHNDAKFVRSGIATADDFFAFLRDSFDMLYAEGATQPKMMSVGLHMRLVGHPGRAAGLARFLDHVAAHERVWVCRRLDIARHWHGLHRPAAR

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Crispr_ID: CP020645_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_4

1290661-1290735

Orphan

Consensus_repeat	Method
CGCCGCGCTGCACGGTGCCTGTCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_4

>merge|CP020645|4|1290661-1290735|CRISPRCasFinder
CGCCGCGCTGCACGGTGCCTGTCCCAACGGGGACAGGCACCCGGATGCCACGCTGCGCTGCACGGTGCCTGTCCC

>CP020645|4|4|1290661-1290735|CRISPRCasFinder
CGCCGCGCTGCACGGTGCCTGTCCC	AACGGGGACAGGCACCCGGATGCCA
CGCTGCGCTGCACGGTGCCTGTCCC

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP57574.1\|1287983_1288643_-\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|223200
CP020645.1\|AWP57570.1\|1285364_1285892_-\|cation-binding-protein	unknown	unknown	gnl\|CDD\|213983
CP020645.1\|AWP57573.1\|1286848_1287925_-\|bifunctional-transcriptional-activator/DNA-repair-protein-Ada	unknown	unknown	gnl\|CDD\|185333
CP020645.1\|AWP57585.1\|1301140_1302067_-\|hydrolase	unknown	unknown	gnl\|CDD\|223669
CP020645.1\|AWP57568.1\|1284065_1284686_-\|2-hydroxychromene-2-carboxylate-isomerase	unknown	unknown	gnl\|CDD\|239320
CP020645.1\|AWP57579.1\|1293320_1293467_+\|DUF2474-domain-containing-protein	unknown	unknown	gnl\|CDD\|371167
CP020645.1\|AWP57569.1\|1284736_1285156_-\|cyclase	unknown	unknown	gnl\|CDD\|273970
CP020645.1\|AWP57567.1\|1283008_1284031_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270321
CP020645.1\|AWP57575.1\|1288744_1289248_-\|glyoxalase	unknown	unknown	gnl\|CDD\|319910
CP020645.1\|AWP57582.1\|1295439_1298601_-\|tetrathionate-reductase-subunit-A	unknown	unknown	gnl\|CDD\|237883
CP020645.1\|AWP57583.1\|1299675_1300449_-\|tetrathionate-reductase-subunit-B	unknown	unknown	gnl\|CDD\|184955
CP020645.1\|AWP61100.1\|1298627_1299662_-\|tetrathionate-reductase	unknown	unknown	gnl\|CDD\|184954
CP020645.1\|AWP57572.1\|1286216_1286852_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378278
CP020645.1\|AWP57584.1\|1300764_1301118_+\|calcium-sensor-EFh	unknown	unknown	gnl\|CDD\|238008
CP020645.1\|AWP57580.1\|1293483_1294905_+\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224089
CP020645.1\|AWP57577.1\|1290912_1292301_+\|cytochrome-ubiquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
CP020645.1\|AWP57571.1\|1285929_1286220_-\|metal-binding-protein	unknown	unknown	unknown
CP020645.1\|AWP57578.1\|1292302_1293310_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	unknown	unknown	gnl\|CDD\|224213
CP020645.1\|AWP57576.1\|1289415_1290573_-\|serine/threonine-protein-phosphatase	unknown	unknown	gnl\|CDD\|277331
CP020645.1\|AWP57581.1\|1295096_1295429_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP57570.1\|1285364_1285892_-\|cation-binding-protein	gnl\|CDD\|213983	cd12108, Hr-like, Hemerythrin-like domain. Hemerythrin (Hr) like domains have the same four alpha helix bundle and a similar, but slightly different active site structure than hemerythrin. They are non-heme diiron binding proteins mainly found in bacteria and eukaryotes. Like Hr, they may be involved in oxygen transport or like human FBXL5 (F-box and leucine-rich repeat protein 5), a member of this group, play a role in cellular iron homeostasis.	1.38579e-12
CP020645.1\|AWP57573.1\|1286848_1287925_-\|bifunctional-transcriptional-activator/DNA-repair-protein-Ada	gnl\|CDD\|185333	PRK15435, PRK15435, bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada.	6.29763e-138
CP020645.1\|AWP57585.1\|1301140_1302067_-\|hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.83987e-27
CP020645.1\|AWP57568.1\|1284065_1284686_-\|2-hydroxychromene-2-carboxylate-isomerase	gnl\|CDD\|239320	cd03022, DsbA_HCCA_Iso, DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-dihydroxynapthalene by a dioxygenase, into cis-o-hydroxybenzylidenepyruvate (cHBPA). This is the fourth reaction in a six-step pathway that converts napthalene into salicylate. HCCA isomerase is unique to bacteria that degrade polycyclic aromatic compounds. It is closely related to the eukaryotic protein, GSH transferase kappa (GSTK).	9.44875e-77
CP020645.1\|AWP57579.1\|1293320_1293467_+\|DUF2474-domain-containing-protein	gnl\|CDD\|371167	pfam10617, DUF2474, Protein of unknown function (DUF2474). This family of short proteins has no known function.	2.47299e-05
CP020645.1\|AWP57569.1\|1284736_1285156_-\|cyclase	gnl\|CDD\|273970	TIGR02096, putative_cyclase, conserved hypothetical protein, steroid delta-isomerase-related. This family of proteins about 135 amino acids in length largely restricted to the Proteobacteria. This family and a delta5-3-ketosteroid isomerase from Pseudomonas testosteroni appear homologous, especially toward their respective N-termini. Members, therefore, probably are enzymes.	1.23413e-52
CP020645.1\|AWP57567.1\|1283008_1284031_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270321	cd13603, PBP2_TRAP_Siap_TeaA_like, Substrate-binding domain of a sialic acid binding Tripartite ATP-independent Periplasmic transport system (SiaP) and related proteins; the type 2 periplasmic-binding protein fold. This subfamily includes the periplasmic-binding component of TRAP transport systems such as SiaP (a sialic acid binding virulence factor), TeaA (an ectoine binding protein), and an uncharacterized TM0322 from hyperthermophilic bacterium Thermotoga maritima. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	5.76567e-123
CP020645.1\|AWP57575.1\|1288744_1289248_-\|glyoxalase	gnl\|CDD\|319910	cd07246, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	6.40007e-55
CP020645.1\|AWP57582.1\|1295439_1298601_-\|tetrathionate-reductase-subunit-A	gnl\|CDD\|237883	PRK14991, PRK14991, tetrathionate reductase subunit TtrA.	0
CP020645.1\|AWP57583.1\|1299675_1300449_-\|tetrathionate-reductase-subunit-B	gnl\|CDD\|184955	PRK14993, PRK14993, tetrathionate reductase subunit TtrB.	3.36133e-131
CP020645.1\|AWP61100.1\|1298627_1299662_-\|tetrathionate-reductase	gnl\|CDD\|184954	PRK14992, PRK14992, tetrathionate reductase subunit TtrC.	7.50285e-43
CP020645.1\|AWP57572.1\|1286216_1286852_-\|hypothetical-protein	gnl\|CDD\|378278	pfam09859, Oxygenase-NA, Oxygenase, catalyzing oxidative methylation of damaged DNA. This family of bacterial sequences is predicted to catalyze oxidative de-methylation of damaged bases in DNA.	2.16932e-49
CP020645.1\|AWP57584.1\|1300764_1301118_+\|calcium-sensor-EFh	gnl\|CDD\|238008	cd00051, EFh, EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.	6.77115e-08
CP020645.1\|AWP57580.1\|1293483_1294905_+\|GntR-family-transcriptional-regulator	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	6.75526e-136
CP020645.1\|AWP57577.1\|1290912_1292301_+\|cytochrome-ubiquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	0
CP020645.1\|AWP57574.1\|1287983_1288643_-\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	1.35503e-52
CP020645.1\|AWP57578.1\|1292302_1293310_+\|cytochrome-d-ubiquinol-oxidase-subunit-II	gnl\|CDD\|224213	COG1294, AppB, Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion].	5.39687e-100
CP020645.1\|AWP57576.1\|1289415_1290573_-\|serine/threonine-protein-phosphatase	gnl\|CDD\|277331	cd07385, MPP_YkuE_C, Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain. YkuE is an uncharacterized Bacillus subtilis protein with a C-terminal metallophosphatase domain and an N-terminal twin-arginine (RR) motif. An RR-signal peptide derived from the Bacillus subtilis YkuE protein can direct Tat-dependent secretion of agarase in Streptomyces lividans. This is an indication that YkuE is transported by the Bacillus subtilis Tat (Twin-arginine translocation) pathway machinery. YkuE belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	4.61496e-80

>CP020645.1|AWP57576.1|1289415_1290573_-|serine/threonine-protein-phosphatase
MSLRRSAFFIRFLTLGALAHVYVGARLIPDAGLPATGVAAAILALCASCVLIPLGMASHASGRQPWGDRLAAVGLVSMGYFSSLFVLTVLRDAALLLAWLAALAALPVPMDALRAASAPAVPLLALAATLLGLANARRRARVVTVDVPIDALPAALQGYTIVQISDLHVGPTIKRRYLQAIVDAVNAAGPDLVAVTGDVVDGPVAHLSPHTQPLAALRAPDGVYLVTGNHEYYSGAAAWVQEFRRLGLCVLQNEHRVVRRGDAALVVAGVTDYGAAAFDASQRSNPAQALAGAPAKAAVRLLLAHQPRSAAAAAPLGYTLQLSGHTHGGQFLPWNWFVRLQQPFTAGLHRYGPMWVYTSRGTGYWGPPKRLGAPSEITRVRLVRA
>CP020645.1|AWP57575.1|1288744_1289248_-|glyoxalase
MATAVKPIPEGMHTLTPHIICAGAARAIDFYIKAFGAVEMARLAGPDGRLMHGAVRIGDSTLMLMDAFPEWDTPDPKALNGTPVVLHLYVEDVDAAHAQAVAAGATSVMPVTDMFWGDRYGQVRDPFGHLWSIATHKQDLTPEQIAEAARNAPPCPDVAEQAGKARE
>CP020645.1|AWP57574.1|1287983_1288643_-|DNA-3-methyladenine-glycosylase
MTAATLSPAAYAHAERFLAGLDADWRGHVAATGPCLHRPLPAREPYEALVRAIAYQQLHARAGDAIVGRLLALFPGGAFPAPGQLLAADPAALRACGFSAAKTQTILGIAQAARDGVVPDRRAARRMSDQALVERLTTLRGVGRWTVEMLLIYTLARADILPADDFGVRDGYRRLKGAAATPTARQMRDIGQAWGPYRTLAAWYLWRVPPEARIRAQET
>CP020645.1|AWP57573.1|1286848_1287925_-|bifunctional-transcriptional-activator/DNA-repair-protein-Ada
MNLPVRPAPAYATPEARWAAVQARDPAADSHFVYAVRTTGVYGRPSSAARLPRRENVEFFDNAEAARAAGYRPSRHNAADRTVTARQHSALVAAACRHIEQADTPPTLEALAAHVGLSPFHLHRLFKAETGLTPKAYASAQRARRLRAELGESASVTAAIYDAGFNSNSRFYEASQQLLGMAPRAYRAGGANARIRFAVAQCALGAILVAQSQLGICAILLDDDPDYLVRQLQDLFPRATLIGGDAGFERLVAEVVGFVEAPALGLNLPLDVRGTAFQERVWQALREVPPGATVSYTDIAERIGAPKAVRAVAQACAANRIAVAIPCHRVVRRDGDLSGYRWGVDRKRELLRREAATP
>CP020645.1|AWP57572.1|1286216_1286852_-|hypothetical-protein
MTPALTPGILQAGATAIAALDRAALHARLDRDGWALLPALFDAPAIAALLACAPPQGPGIAAGVFAPLRAALYAQLAPLANAWAQTLQTGWRYPASAPAGVPPDIRLDVVETGHARPLTQHEPAPDVFPLQLVVLLSDPKRDFAGGELVLTEQRPRMQSRPIVIPLRQGDAALIPTAHRPCRGAHGFYRASLRQAISPVRAGRRVGLALLP
>CP020645.1|AWP57571.1|1285929_1286220_-|metal-binding-protein
MSPSARRWRLIGADGQPLLSAEPGTLGGHRRGRLYGRLDCRAAARALARGGYAAQRVFFLDEASAVAAGYRPCAVCMPQAYAAWKTARAHKRAAME
>CP020645.1|AWP57570.1|1285364_1285892_-|cation-binding-protein
MSSAFPAPAPDFDQPLQLLAACHGRIERQCATLERLAAHLRAQGSDDAARTAAASVMRYFDSAAVKHHEDEEQDLFPALIESMAGSDAVCLRQLVGSLTDEHRALGSAWRRVREVLQQVADGQGAAFAPGQAEDFVAAYRAHLRREDEELLPLAERLLDDGALADMAQAMRDRRS
>CP020645.1|AWP57569.1|1284736_1285156_-|cyclase
MTWRVDLIAQHIEVENRHLMDEMLATLADENPVRDEVAGRVYRGKDQVAARYAELWQAFPDFNVRPVRYTEQEGIVVMEAIYTGTHHGAYLGLPGSGKSFNVRLVNVFGFDDERIESETIYIDLAGQLRQLGITAIPRN
>CP020645.1|AWP57568.1|1284065_1284686_-|2-hydroxychromene-2-carboxylate-isomerase
MHIDYYFSVVSDWAYFGGERLERLARRHGATIRHKPMQLSAVYAQTGGILLQQRSTQRQAYRVTELERWRDHLGIPITLHPRHYPVDDIPASCAILAAQELGMATGDYANAVLRAIWTQERDISDPRTLDEIARGLGLDADAILQLAQAPHIRQRLADNTREAIGHGVFGSPFYLCNGHLFWGQDRLPFLEDVLAGRVGAYAGAPA
>CP020645.1|AWP57567.1|1283008_1284031_-|ABC-transporter-substrate-binding-protein
MLRTARTTLAIIAAATLLAACDKGGADRPQAASGAQPRTLQLAHVSVENEDDMYHHLAAGFAERVARHTDGAVKVQVLGGAQLGGERDVAEGMQLGSIDMSVIASFALGAFEKKAMIFDLPYLFKDYPTAFQALDSSFTDGIEADLEKTGLKVLGWGHGGFRNLYNSKQPIRTLADLKDMKVRMPENPIYVDTWRALGVNVTSMAYPELFTGLQQRTIDGAENPTALYYTSRFYEAAKYLSKTEHVYVAIPIVVSARIWTSLAPEQQAAFQQAADEAIAAQRQFLLATEAATEKKLAEAGVAINTDVDKAAFRQAAAPVYERYRNTIDPELVNRAQALAQ
>CP020645.1|AWP57577.1|1290912_1292301_+|cytochrome-ubiquinol-oxidase-subunit-I
MMSSEALLLARIQFGFTISFHIIFPAITIGLASYLAVLEGCWLRTRDTVYRDLYHFWSKVFAVNFGMGVVSGLVMAYQFGTNWSAFSEFAGSITGPLLAYEVLTAFFLEAGFLGVMLFGWSRVGPRLHFFSTIMVALGTLVSATWILASNSWMQTPAGYEIVDGRVVPVDWLAVIFNPSFPYRLAHMSIAAFLATALLVAASGAWHLLRGHRTPAVRRMFAMALGMLAIAAPLQAVVGDMHGINTLKHQPAKIAAIEGHWENVPGEGVPLHLFGVPDMQAETTRYALSVPRLGSLILTHSLDGQFPGLKSYPPADRPNATVVFWSFRVMVGLGLLAIALAAWAGWARLRGRLYDSRALQRFALAMGPSGLVAILAGWYTTEIGRQPWIVQGLMRTADAATPHGVPALTLTLLLFVFVYLIVFGAGIVYVLRLIARGPSGSAPAGGEPGLVQRPLAAAQQGGL
>CP020645.1|AWP57578.1|1292302_1293310_+|cytochrome-d-ubiquinol-oxidase-subunit-II
MGVDLSLIWAIIILFGVMMYVVMDGFDLGIGVLFPLLPGKSDRDVMMNTVAPVWDGNETWLVLGGAGLLAAFPRAYAVVLGALYLPLVFMLLGLVFRGVAFEFRFKADEHHRPFWDRAFIGGSVAAAFFQGAALGAYLQGIELVDGAYQGGPWGWVTPFSLFCGAGLVVAYALLGCTWLIMKTEGALQRRMIVVARPLTGALLAVIAAISVWTPLIEPAIARRWFSLPNFYAFAPVPVLVLAAAWGLLRALRGQPDMAPFLLTLALVFLGYSGLCISLWPHAIPPGVTLWEAAAPPQSQGFALVGALFIVPIILTYTAWSYYVFRGKVRAGDGYH
>CP020645.1|AWP57579.1|1293320_1293467_+|DUF2474-domain-containing-protein
MTEDTLDRPASTLRRLGWLALLWAGGVAGLGLAAGGLKLIMKLAGLTP
>CP020645.1|AWP57580.1|1293483_1294905_+|GntR-family-transcriptional-regulator
MKLKRYEVLADEITASIQAGTRRAGDRLPSVRQTSASRGLSATTVFKAYYLLEARGLIRARDRSGYYVVGKPKALPPELEAGAPAESRRVDVDVSDRVLHVLQLTMRRDVVPFGSAFPHPSLFPHARLARAMASSVAALDPWSSVDDLSAGNTRLRRAIALRYLADGVQVRTEDIVITNGALEALNLCLGAVTRPGDSVLIESPTFYSALQSLERLGLRAIEVPAHPREGIELDALARAIDTHRPAACWLMTNFQNPLGSLMPEDKKRALVELLAARDVPLIEDDVYSELYFGAQRPLPAKAYDESGIVMSCSSFSKSLAPGWRIGWVLGGRYADRILRGKLALSLSTSAPSQAALATYLEHGGYDRHLRQLRQTLEQQRNQVMEAIARHFPPGTRTTHPDGGYFLWVALPPQVDALAVHRAALSLGVSTAPGPIFSVQDRFRHCLRLNYGHPFDARAQDGLATLGKLIARQC
>CP020645.1|AWP57581.1|1295096_1295429_+|hypothetical-protein
MYRGHEAIKQFMQAIGLPWTPGQAESAELRASYRIGSGRPLNIDRTRVEFHCDDARAKVWVPEFARTSFHQWFEVAYQDFEYAPGASMLKIKAAARGNAAAYSVGLKPLA
>CP020645.1|AWP57582.1|1295439_1298601_-|tetrathionate-reductase-subunit-A
MPKQHPTPDTDAPADARRRKLIARGGAVAGGMAAFAAGYGETVARAVKGLAQGSAGAPTADALRGNSLTPEFRIDPVTGALSAQPGQTVSPSSCLGCWTQCGVRLRVDTETNRILRVAGNPYHPLATTQPAPMHAPVREVYARLGGDNGLEGRATSCARGSAMLEQLTSPYRVLQPLKRVGPRGAGQWRTISFEQLVEEVCEGGDLFGEGHVDGLRAIYDPVTPLDPDNPEYGPRSNQLLFTDSANEGRTPLIQRFAAQSFGTVNVSNHGSYCGQSFRVGTGAAFGDLKGMPHGKPDWTRARFGLFIGTAPAQSGNPFQRQGRQLAEARVRDDGAGFHYVVVSPVLPASASLAAGSGNEWLAVNPAGDLALVMGMIRWILEHGRYDAAMLSQPGPAAMDAAGEAAWTNATHLVIDAPGHARHGSCLRGADLGWPRAGADPQAEDVYVVQRPDGTLAPHTHAGPAALFVERDLPAAGVAPGLGGVRASSALALLRREARRMTLDDYARHSGVPAARIAGLAERFTSHGKQAVADAHGGTMSGAGFYTAYAIAMLNTLVGNLNVAGGLVLDGGPFAPYGKGPRYDIAGFAGRVAPRGVSLSRNRFPYEKSSEYRRKAEAGQSPYPAQSPWYPATGALSSEMLASALAGYPYRAKVWLNHMSNPVYAIAGLKNVIADKLRDPGLLPLSVSINAFINETNALADYIVPDTITYESWGVSAPWADVQAKASTVRWPAVAPRVARTANGEPVCLESFLIACAKRLGMPGFGADAIAGRDGRRHALDTASDFFLRGMANMAYAGGAPVAEASEDDLALTGVDRHADLLRRTLQDDEWRRVALLMSRGGRFDAAEDVWRDGRVHPPYRKPLHVWSEDLARMRHAMTGEPYSGCPTWYPTRLADGRAMREQYPQADWPFLLSSFKSNLMSSMSIGVSRLRQVHPHNPVSISRADASRLGIGNGDAVRIVTPGGAVTGLALVRDGVQPGAIAIEHGYGHTELGARAHVVDGRPMPHDPALAAGVNLNDLGFGDATRALRDNVWIDWVSGAAVRQGLPARLEKA
>CP020645.1|AWP61100.1|1298627_1299662_-|tetrathionate-reductase
MRISELITPVYDAAWLPWAVQYFFLIGISAATALTAAACAFGRSGSARARLLPAAIAVLAVSAVAAPVSLLADLHQPGRFWHFYTQATPWSWMWLGALLLPLYAALALGLCAAWWLGWRRAMRALAVPLALSALSILVYTGSEVMVLRSRPLWHTVFLPINFALTGWLGALGAMLLLGRWLPGGLAAVPMALLRRLAMAALAALAASAGAWAVLGLLGHEPSFDAALRLFAQFPAWRASLAGAIATGLCMAALLQMRPARLAGPAASLALALTLLAAAWIFRWVVFMNVQGVPKYGAGLYLYDMPWGSDGLLGMAGVLGLCVALVAALAWALERFPARTAAPAR
>CP020645.1|AWP57583.1|1299675_1300449_-|tetrathionate-reductase-subunit-B
MHNAPSSDRPPAPGKRGFLKELLGLAATATVIPIAPEARAGMNAQPPRRPGAAGKRYGMVVDLRLCIGCQACTVSCSMENLPPIGQFRTTVLQYEVLPDDGGPCSMVMLPRLCNHCDNPPCVPVCPVQATFQREDGIVLVDNERCVGCGYCVQACPYDARFINHETQTADKCTFCEHRLEAGLLPACVESCVGGARVIGDLNDPASAVSRLLAEHRDEVKVLKPDMRTDPHVYYIGLPDAFVNQIDGQAGVRLAGRH
>CP020645.1|AWP57584.1|1300764_1301118_+|calcium-sensor-EFh
MKKTIIASAACAALLATSGAVLAQSGASLTPDQLQHLDTDKSGGVSQKEYQAFMEASFAKLDANGDGSLTRQELPQEVSDAQFTAMDANKDGRVSRQEFLGQVMRDFATASRGGELK
>CP020645.1|AWP57585.1|1301140_1302067_-|hydrolase
MTQSNQTTSPSADAHVKHRYLDLDELRIFYREVGPADAPVVLLPHGYPCSSFQYRDFMPALADQWRLLAPDFPGFGYSDTPDTARFACDFEHYTDFLQQFAHALGLPSYALYLHDYGSQIGLRLAMREPDKVSGLIIQNGDIYEDELGPRYAPLQAYWADPTLEGRYKLSLAVSEEGFRDEFLNDLPDEQAECITPDMWKLAWALLREPRRREIMVGLMEGLEDNLAWFPRYQAYLRERQPPTLIVWGVHDGYMPEAAARAYLRDLPDAELHLLQAGHWALETHLAPIVALTRAFLQRVHATPNFPPP

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Crispr_ID: CP020645_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_5

1423960-1424070

Orphan

Consensus_repeat	Method
AGCGGGCGCAGCGTGGGGGCTTTTTTTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_5

>merge|CP020645|5|1423960-1424070|CRISPRCasFinder
AGCGGGCGCAGCGTGGGGGCTTTTTTTGCCGCCGGGCCGCCCCAAGGCAAAAAGGCCCCCTCGGGGGGCAGCAAGCGCGCATAGCGGGCGCAGCGTGGGGGTTTTTTTGCT

>CP020645|5|5|1423960-1424070|CRISPRCasFinder
AGCGGGCGCAGCGTGGGGGCTTTTTTTGC	CGCCGGGCCGCCCCAAGGCAAAAAGGCCCCCTCGGGGGGCAGCAAGCGCGCAT
AGCGGGCGCAGCGTGGGGGTTTTTTTGCT

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP57701.1\|1433460_1434615_-\|aminotransferase	unknown	unknown	gnl\|CDD\|180937
CP020645.1\|AWP57686.1\|1414883_1415612_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239483
CP020645.1\|AWP57695.1\|1428991_1429708_+\|hypothetical-protein	unknown	unknown	unknown
CP020645.1\|AWP57694.1\|1427305_1428727_-\|siroheme-synthase	unknown	unknown	gnl\|CDD\|182606
CP020645.1\|AWP57685.1\|1413299_1414727_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237673
CP020645.1\|AWP57696.1\|1429792_1430110_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377576
CP020645.1\|AWP57699.1\|1430967_1432512_-\|3-octaprenyl-4-hydroxybenzoate-decarboxylase	unknown	unknown	gnl\|CDD\|236796
CP020645.1\|AWP57684.1\|1412280_1413303_-\|PhoH-family-protein	unknown	unknown	gnl\|CDD\|224616
CP020645.1\|AWP57691.1\|1420448_1421522_-\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	unknown	unknown	gnl\|CDD\|234666
CP020645.1\|AWP57700.1\|1432595_1433426_+\|transglycosylase	unknown	unknown	gnl\|CDD\|381594
CP020645.1\|AWP57692.1\|1421679_1423116_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|224938
CP020645.1\|AWP57688.1\|1416878_1418759_-\|protein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
CP020645.1\|AWP57693.1\|1424482_1427239_+\|pertactin	unknown	unknown	gnl\|CDD\|273608
CP020645.1\|AWP57697.1\|1430150_1430564_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377816
CP020645.1\|AWP57687.1\|1415893_1416829_-\|protein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
CP020645.1\|AWP61112.1\|1423206_1423848_+\|uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
CP020645.1\|AWP57698.1\|1430565_1430925_+\|hypothetical-protein	unknown	unknown	unknown
CP020645.1\|AWP57690.1\|1419315_1420452_-\|tRNA-guanosine(34)-transglycosylase-Tgt	unknown	unknown	gnl\|CDD\|234642
CP020645.1\|AWP61113.1\|1434789_1435530_+\|hypothetical-protein	unknown	unknown	unknown
CP020645.1\|AWP57689.1\|1418825_1419170_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|235518

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP57701.1\|1433460_1434615_-\|aminotransferase	gnl\|CDD\|180937	PRK07337, PRK07337, pyridoxal phosphate-dependent aminotransferase.	0
CP020645.1\|AWP57686.1\|1414883_1415612_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|239483	cd03389, PAP2_lipid_A_1_phosphatase, PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.	6.13555e-75
CP020645.1\|AWP57694.1\|1427305_1428727_-\|siroheme-synthase	gnl\|CDD\|182606	PRK10637, cysG, siroheme synthase CysG.	6.32102e-175
CP020645.1\|AWP57685.1\|1413299_1414727_-\|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB	gnl\|CDD\|237673	PRK14325, PRK14325, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0
CP020645.1\|AWP57696.1\|1429792_1430110_+\|hypothetical-protein	gnl\|CDD\|377576	pfam05957, DUF883, Bacterial protein of unknown function (DUF883). This family consists of several hypothetical bacterial proteins of unknown function.	1.02514e-26
CP020645.1\|AWP57684.1\|1412280_1413303_-\|PhoH-family-protein	gnl\|CDD\|224616	COG1702, PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms].	4.19811e-141
CP020645.1\|AWP57691.1\|1420448_1421522_-\|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0
CP020645.1\|AWP57700.1\|1432595_1433426_+\|transglycosylase	gnl\|CDD\|381594	cd00254, LT-like, lytic transglycosylase(LT)-like domain. Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.	5.91272e-19
CP020645.1\|AWP57692.1\|1421679_1423116_+\|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|224938	COG2027, DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane].	3.9844e-89
CP020645.1\|AWP57688.1\|1416878_1418759_-\|protein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	0
CP020645.1\|AWP57693.1\|1424482_1427239_+\|pertactin	gnl\|CDD\|273608	TIGR01414, Contains:_AIDA-I_translocator, outer membrane autotransporter barrel domain. A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	4.07951e-113
CP020645.1\|AWP57697.1\|1430150_1430564_+\|hypothetical-protein	gnl\|CDD\|377816	pfam07332, Phage_holin_3_6, Putative Actinobacterial Holin-X, holin superfamily III. Phage_holin_3_6 is a family of small hydrophobic proteins with two or three transmembrane domains of the Hol-X family. Holin proteins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion.	2.48727e-14
CP020645.1\|AWP57687.1\|1415893_1416829_-\|protein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	7.49349e-144
CP020645.1\|AWP61112.1\|1423206_1423848_+\|uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	1.36406e-125
CP020645.1\|AWP57699.1\|1430967_1432512_-\|3-octaprenyl-4-hydroxybenzoate-decarboxylase	gnl\|CDD\|236796	PRK10922, PRK10922, 4-hydroxy-3-polyprenylbenzoate decarboxylase.	0
CP020645.1\|AWP57690.1\|1419315_1420452_-\|tRNA-guanosine(34)-transglycosylase-Tgt	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	0
CP020645.1\|AWP57689.1\|1418825_1419170_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|235518	PRK05585, yajC, preprotein translocase subunit YajC; Validated.	5.53938e-43

>CP020645.1|AWP61112.1|1423206_1423848_+|uracil-phosphoribosyltransferase
MPVHEIRHPLIRHKLGIMRRADLSTKSFRELSQEVAALLTYEATKDMPLAPASVEGWCGTVEVDKIAGKKVTVVPILRAGIGMLDGVLSLIPGAKVSVVGVARNEETLQAHTYLERLVGELDQRLALIVDPMLATGGSMVAAIDMLKRAGCREIRALTLVSAPEGIDAVLNAHPDVQIYTASIDQGLNENGYIMPGLGDAGDRIFGTTQKHAE
>CP020645.1|AWP57692.1|1421679_1423116_+|D-alanyl-D-alanine-carboxypeptidase/D-alanyl-D-alanine-endopeptidase
MRRAGKQGKWQQWLAGVMLVLGAAGAAAQGLPSSLVAAWKATKLPDQSLSLVVQEINGPRLATLNAKEPRNPASVMKLVTTWAALSELGPSYAWRTEFLTEPGNRPDAHGVLRGPLYLRAGGDPQLLLQDLWALLRELRLRGVKQIGDLVVDRSIFGQVAIDPGAFDGASDRAYNASPDALMVGFGAQRLLFTPDAAARKWVPMIDPPLPGLRLEGAVEWSDVRCPGPPVVGTEPVVTQQGVSIRLSGKVAGSCGEFSLYRLALSQPEYASAVFRLLWRELGGTLKGQIRSGVVPPDAVVLASHDSPTLGEAIRTINKRSNNVMARTLLLTLGAERGRRPATVESSGVVARAVLGAQGLEMPELVIDNGSGLSREGRVSADSLASMLTVAWNSPLMPEFISSLAIAGVDGTVRRRLKGNGAQGMAHLKTGSLRDVRAVAGYVLGASGKRYVVVSMVNHENAAAVRSFDDALVAWLAEQ
>CP020645.1|AWP57691.1|1420448_1421522_-|tRNA-preQ1(34)-S-adenosylmethionine-ribosyltransferase-isomerase-QueA
MAAAFHRTYRVPTPLTLADFDYHLPPELIAQSPAAERGGSRLLHLDAASRLHDRRFPDLAGLLRPHDLLVFNDTRVIKARLTGQKATGGKVEVLVERITAPDRALAHVRASKSPGPGMRLRLAEAFEAEVLGREGELFDLRFPAPVLDLLDAHGATPLPPYITHAADATDERRYQTVYAREPGAVAAPTAGLHFDQPMLEQLAAQGVQRAFVTLHVGAGTFQPVRVQNLAEHIMHAEWYTVPEATVAAIARARAHGGRIVAVGTTSVRALESAAAQAQDGPLAAAQGDTRLFITPGYRYRVVDALLTNFHLPQSTLLMLVSALAGVEPIRRAYAHAVAERYRFFSYGDAMFIETPAP
>CP020645.1|AWP57690.1|1419315_1420452_-|tRNA-guanosine(34)-transglycosylase-Tgt
MTGLQFELLATDGGARRGRLTLNHGVVETPIFMPVGTYGSVKAMLPHELEDIGAQIVLGNTFHLWLRPGTAIMEKHGGLHGFMQWDKPILTDSGGFQVFSLQGMRKITEEGVKFASPIDGARLFLTPEESMRIQRSLNSDIVMVFDECTPYEIDGRPASIDEAARSMRMSLRWARRSRDEFDRLGNPNALFGIVQGGMYETLRDESLAGLAEIGFHGYAIGGLSVGEPKEDMMRILAHVTPRLPAQAPRYLMGVGTPEDLVEGVARGVDMFDCVMPTRNARNGWLFTRYGDVKIRNARYRDDTRPLDPSCACHTCTHFSRAYLHHLQRANEITGARLNTLHNLHFYLAIMGEMREAIAAGRFEAWRAQFAADRARGVD
>CP020645.1|AWP57689.1|1418825_1419170_-|preprotein-translocase-subunit-YajC
MSAIDTAGLVLAQAAPAEGNALMGMLPIVLMFVILYFLMIRPQMKRQKEHRNMVAALSKGDEVVTSGGMLGRVSKVTDSYITVEVSELADKPVEVVMQKTAVSAVLPKGTIKAL
>CP020645.1|AWP57688.1|1416878_1418759_-|protein-translocase-subunit-SecD
MNRYPLWKYITVLVAVVIGLLYTLPNFYGESPAVQVSSAKATIKVDQATLEQVQQIIENAQLPADSVYYEQNGTLGTVRARFPSTDVQLQARDLIDRTLNTVAGDPHYTVALNLLPASPPWMRSLGWFEPKPMYLGLDLRGGVHFLLQVDMQGALTARYDSLVADVRSALRDQKAEVGAIERSGQSVVATFATAEQRDRARDVLRSRLPDLQFTETSDGGKLQLTGMLNPAAVTRVQDTALKQNINTLHNRINELGVAEPVIQQQGADRIIVQLPGVQDVAKAKELLGRTATLEIRMVDDSPAAQSALAAGSVPFGLERYTDRDGRPLLVRRQVVLTGENLQDAQPGRDGQTQQPAVHLTLDSKGARIFRDVTRDNIGKRMAILLFENGKGEVVTAPVIRSEIGGGQVQISGSMTAEEAADTALLLRAGALAAPMSIIEERTIGPSLGADNIAKGFYSTLYGFIAIAIFIIVYYHLFGIFSTIGLTVNVLLLLALLSMLQATLTLPGIAAIALTLGMAIDANVLINERIREELRNGATPQQAIHHGFERAWGTILDSNLTTLIVGLALLAFGSGPIRGFAVVHCLGIVTSMFSSVVGVRALANLWYGRKKKLSSISIGTVWKPKAN
>CP020645.1|AWP57687.1|1415893_1416829_-|protein-translocase-subunit-SecF
MEFFRIHRTIPFMRHALVLNIISLVTFLAAVFFIITRGFHLSIEFTGGTVMEVSYAQTAQLDQVRTAIGTLGYTDFQVQNFGTSRDVMIRLPIAEGQTSATQSETVMGALKAADPAVELRRVEFVGPQIGQELLHNGLMALLVVVIGIMVYLGLRFEWKFAVAGVIANLHDVVIILGFFAFFQWEFSLAVLAGVLAVLGYSVNESVVIMDRIRENFRKYRKASVQEVINSAITQTISRTIITHGSTQMMVLAMLFFGGPTLHYFSLALTIGIWFGIYSSVFVAAALAMWMGVKREDLVKPVKKDGDEVEIA
>CP020645.1|AWP57686.1|1414883_1415612_+|phosphatase-PAP2-family-protein
MTAEPITAFPPPKSGLPGQGLAGLLRRCLVPVLLLLGCAAWLDRPLTLWINRSVSPQVNTVFDYIGNLGDSGTYVALGLAAYILGLQGMLRGWAVPWGWTCEKIARAGMLLLATLTAGGLATWVLKNVVARARPEVLLDDGIYGMGRMFAGNPFNSFPSSHTQTAFAVAAVLGILAPRWRWPALALAALVAISRVINRDHYLSDVCAAALIAVVAAYAIKPYVLSPRYTWPLRAPWRWRKRG
>CP020645.1|AWP57685.1|1413299_1414727_-|tRNA-(N6-isopentenyl-adenosine(37)-C2)-methylthiotransferase-MiaB
MQETTVKRDGASPSDAGTPATAAQGLGKLYIRTFGCQMNEYDSDKMADVLRADQGLELTDNPEDADVILFNTCSVREKAQEKVFSDLGRVQHLKKQNPNLVIGVGGCVASQEGEAIVKRAPYVDVVFGPQTLHRLPDLIKRRRAQGVSQVDISFPEIEKFDALPPPRVDGATAFVSIMEGCSKYCSFCVVPYTRGEEVSRPFDDVLLEVADLADQGVKEVTLLGQNVNAYRGAMGDSGEIADFAMLLEYVHEIPGIERIRYTTSHPKEMTQRMVDAYARLPKLVSFLHLPVQAGSDRVLAAMKRGYTALEFKSVVRRLRAARPSLTLSSDFIVGFPGETEEDFQKTMKLIEDVGFDTSFSFVYSRRPGTPAADLHDDTPQDVKLRRLQQLQALINQQAAAIAQGMIGTRQRVLVEGPSRRDPNELMGRTENNRIVNFPGVPRLIGHMVDVVVTHAHTNSLRGRVAGIERDTSGAE
>CP020645.1|AWP57684.1|1412280_1413303_-|PhoH-family-protein
MSTSRSRARRTMPAIVNLDGDNIHLANLCGPLDENLRQLADGMGVKLARRGSRVTIEGEQAELAGRALRRFHEQATHRALSVDDIQLGLVEIGVGRPVEVQADPRELDQTLPPVDDESGGVVLRTRRTDLRPRTPRQRDYMNNILKHDITFGVGPAGTGKTWLAVACAIDAMERDTVQRLVLTRPAVEAGERLGFLPGDLAQKVDPYLRPLYDALYDLMGFERVQRLFEKQTIEIAPLAYMRGRTLNHAFVILDEAQNTTPEQMKMFLTRIGFGSKAVITGDPSQVDLPRGQQSGLAHAVQVLEEVQGIATTRFTSRDVVRHPLVARIVDAYDQAAANGD
>CP020645.1|AWP57693.1|1424482_1427239_+|pertactin
MNMSLSRIVKAAPLRRTTLAMALGALGAAPAAHADWNNQSIVKTGERQHGIHIQGSDPGGVRTASGTTIKVSGRQAQGILLENPAAELQFRNGSVTSSGQLFDDGIRRFLGTVTVKAGKLVADHATLANVGDTWDDDGIALYVAGEQAQASIADSTLQGAGGVQVERGANVTVQRSAIVDGGLHIGALQSLQPEDLPPSRVVLRDTNVTAVPASGAPAAVSVLGASELTLDGGHITGGRAAGVAAMQGAVVHLQRATIRRGDAPAGGGVPGGAVPGGFGPGGFGPGGFGPVLDGWYGVDVSGSTVELAQSIVEAPELGAAIRVGRGARVTVSGGSLSAPHGNVIETGGARRFAPQAAPLSITLQAGAHAQGKALLYRVLPEPVKLTLTGGADAQGDIVATELPPIPGTSSGPLDVALASQARWTGATRAVDSLSIDNATWVMTDNSNVGALRLASDGSVDFQQPAEAGRFKVLTVNTLAGSGLFRMNVFADLGLSDKLVVMQDASGQHRLWVRNSGSEPASANTLLLVQTPRGSAATFTLANKDGKVDIGTYRYRLAANGNGQWSLVGAKVPPAPKPAPQPGPQPPQPPQPPQPPQPQPQPEAPAPQPPAGRELSAAANAAVNTGGVGLASTLWYAESNALSKRLGELRLNPDAGGAWGRGFAQRQQLDNRAGRRFDQKVAGFELGADHAVAVAGGRWHLGGLAGYTRGDRGFTGDGGGHTDSVHVGGYATYIANSGFYLDATLRASRLENDFKVAGSDGYAVKGKYRTHGVGASLEAGRRFSHADGWFLEPQAELAVFRAGGGAYRAANGLRVRDEGGNSVLGRLGLEVGKRIELAGGRQVQPYIKASVLQEFDGAGTVRTNGIAHRTELRGTRAELGLGMAAALGRGHSLYASYEYSKGPKLAMPWTFHAGYRYSW
>CP020645.1|AWP57694.1|1427305_1428727_-|siroheme-synthase
MTLFPIFADLTGRRVLVVGGGAVAVRKTQALLQAGAEVVVGAPRLDPALAALAEQGGIARLDGGFEPAWLAGAWLVVAATDDRAVNAAVSEAARARRVFCNVVDDAELSSFQVPSVVDRSPLIVAISSSGVAPVLARRLRERIESLFDHSLGQLAALAARYRPRIRAARPDLGQRRRFYDWLLDGPVAARLRQQQPGLAEQELEQALRAPQAAPRGSVVLVGAGPGDPGLLTLKALRALNEADIILYDRLVSEGVLALARRDAERVPVGKLPGEDHDATQARIHALMLAQARAGRRVVRLKGGDAFIFGRGGEELEYLRAHDVPYEVVPGITAALACAAYAGIPLTHRDHAQSVRMVTAHCRADQDTLDWAGLARDQQTLAFYMGVGQLDYVTARLLEHGRAPATPFALIENGSRPEQRVVTGMLADLPEIARRRGVRPPALLVIGEVAALADTLQWFGQHQRGLPGPQALAA
>CP020645.1|AWP57695.1|1428991_1429708_+|hypothetical-protein
MMVRFFVSIGVLAWAGAAQAGVCDAKFMHDGGQVQLTGSGNIGLGADLGFTEVSKTNGDNCRARVQGMATFSYAGLPPGKSRLDYLMTVKNGQATFVKYAEAGEQPRSEGQFDLRMLGLFAYDKISGEGQRLPGASYRLRIGKEAPVGGQPTTVVRIGEKTVGARQDLSTALGRHACWPITYPRSSEPTMATFKGLTLPIPGMDTTVTDWYCPSVNLVMRQDIDQAGIKSSVEITQLK
>CP020645.1|AWP57696.1|1429792_1430110_+|hypothetical-protein
MAARRSDEATKEKLIDSVKTSLNDAETLLREAASTTGDKATELRERALASVRRTREALYDAQDAVLERGRRAARATDDYVHDNPWQAISIAGVTGLLLGLLISRR
>CP020645.1|AWP57697.1|1430150_1430564_+|hypothetical-protein
MGLRRSVFGVAASLVGLTRTRLELLALEAAGEKIRLIKLLGMAFGALLFLTLAVLVFTITIAVAFWPTESRYAALGWLAGGYGVIGLVLFFLVRRDLVDGPVPFAATLEELGRDTDMLERVRDAQRASDGQRNAEDD
>CP020645.1|AWP57698.1|1430565_1430925_+|hypothetical-protein
MARHSASVDRMVRLELLRARAALEREALAQGIVEAGRTLTPSNMVKSIWPSLGKANTSRLFWQAFALVRRYPFVSSTLSAMVMGRGARRSRLLKLAGVALVGWQAYRLWQSAREERQAD
>CP020645.1|AWP57699.1|1430967_1432512_-|3-octaprenyl-4-hydroxybenzoate-decarboxylase
MKYRDLRDFLAQLERQGELKRITAPVSTRLEMTEIADRVLRAGGPALLFENARHNDAPADMPVLANLFGTPRRVAWGMGADDVGALRETGELLASLREPEAPKGLRDALAKVSMLKAALWDMSPKTVRGAACQEIVWEGADVDLGRLPIQTCWPGDVAPLLAWGLVITRGPNARRQNLGIYRQQPLGPNKLIMRWLSHRGGALDFRDHAQAHPGKPFPIAVALGADPATILGAVTPVPDTLSEYQFAGLLRGSRTEVVKALGSDLSVPASAEIVLEGHLLPADDPRAVAAVVPEGANPPPATGYEMALEGPYGDHTGYYNEQDWFPVFTVDRITMRRNPIYHSTYTGKPPDEPAVLGVALNEVFVPLLRRQLPEIVDFYLPPEGCSYRLAVVSIRKQYAGHAKRVMFGLWSVLRQFMYTKFIVVVDEDIDPRDWTEVVWAMTTRMDPVRDTVLVENTPIDYLDFASPVSGLGGKMGLDATNKWPGETSREWGTPIHMDEAVKRRVDAMWDTLGL
>CP020645.1|AWP57700.1|1432595_1433426_+|transglycosylase
MPDASVAGLFRQLAQGVHHHLAEWLRISSVYLGIAVIVTVSMGFALPGLRDQALQVHKALLTALAPTSMPSAELEPGAEAGADASSAVVMAIPSAPASNATGFLGPLRSDTPPAPPNRPSAASSAQVEALRNYISRKYKVAYDATAVLVNTVYKVGREKQLDPLLLLAVIAIESRYNPFAESPVGAQGLMQVMTRVHQDKFDAIAHVGKGNPLDPVANIHVGSTILKDCINRRGSLNGGLACYVGATGPDDGGYGAKVLAERRRLALASGIALARD
>CP020645.1|AWP57701.1|1433460_1434615_-|aminotransferase
MPRLATRTNDFLTFQVVELFKEAQALQAAGRDIISLGIGEPDFTAPPQVVEALERAARAGLSGYSAPAGLSALREAIAAFYESEFGARVDPARIIVTAGASGALALACAALVNPGAQVLMPDPSYPANSNFVLAAGGQPRLIPSTAAKRFQLSAQDVRDHWNDATQGVLIASPSNPTGTSIAHDELAELLAAVRERQGFSIVDEIYLGLSYESQPRSALLLDDDIIVINSFSKYFHMTGWRLGWMIVPESMAAKVEKMAASLAICAPTLAQHAALACFTPDALKIFEHRREAFKQRRDYLLPEFERLGIPVPVRPDGAFYIYADIAALGTTSMAFSHRLLHEGGVAAVPGLDFGPAHGERTMRFSYATGLDRLQEAVARIEKLL
>CP020645.1|AWP61113.1|1434789_1435530_+|hypothetical-protein
MLRARSDAEVRRARALCQEYGVSLGLPGARPAGRPVLQIDPRGLRALAPEGGAWRAGPGCLAGELAAAGLGQFAEVAPTCTLADWLADSRGWPTGETGASGVLEASVLLADGTAEALGPFGAADVRPLRSATVQRLVPALFQLAGGQDAAACLAQPAWPARYRLDALQPREPAGVNLAHLLLGHDGALAWVESVLLAPAAAPPPAASGSAPAEAARLDARVRALFDPDGVLAARAGSGAVGAKGRE

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Crispr_ID: CP020645_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_6

1480672-1480770

Orphan

Consensus_repeat	Method
GCCGGTGCCAGTCCCCCTTGCGGGGACAGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_6

>merge|CP020645|6|1480672-1480770|CRISPRCasFinder
GCCGGTGCCAGTCCCCCTTGCGGGGACAGGCACTTCGCGGATTGGGACAGGCACGCGGGGAAGTTTGCCGGTGCCAGTCCCCCTTGCGGGGACAGGCAC

>CP020645|6|6|1480672-1480770|CRISPRCasFinder
GCCGGTGCCAGTCCCCCTTGCGGGGACAGGCAC	TTCGCGGATTGGGACAGGCACGCGGGGAAGTTT
GCCGGTGCCAGTCCCCCTTGCGGGGACAGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP57749.1\|1478502_1480062_+\|acetolactate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|236063
CP020645.1\|AWP57753.1\|1484042_1484930_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182990
CP020645.1\|AWP57741.1\|1470634_1471825_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	unknown	unknown	gnl\|CDD\|235674
CP020645.1\|AWP57756.1\|1487580_1488693_-\|D-alanyl-D-alanine-endopeptidase	unknown	unknown	gnl\|CDD\|236952
CP020645.1\|AWP57748.1\|1477621_1478374_+\|glutamine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
CP020645.1\|AWP57744.1\|1474132_1474969_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
CP020645.1\|AWP57754.1\|1484967_1485900_+\|site-specific-tyrosine-recombinase-XerD	unknown	unknown	gnl\|CDD\|234713
CP020645.1\|AWP57757.1\|1489379_1490582_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
CP020645.1\|AWP61115.1\|1485913_1486402_+\|aminoacyl-tRNA-deacylase	unknown	unknown	gnl\|CDD\|237976
CP020645.1\|AWP57743.1\|1473018_1474041_+\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270410
CP020645.1\|AWP57755.1\|1486521_1487100_+\|protease	unknown	unknown	gnl\|CDD\|153243
CP020645.1\|AWP57751.1\|1480917_1482174_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173840
CP020645.1\|AWP61116.1\|1487172_1487574_+\|aryl-sulfate-sulfotransferase	unknown	unknown	gnl\|CDD\|226771
CP020645.1\|AWP57742.1\|1471829_1472882_+\|threonylcarbamoyl-AMP-synthase	unknown	unknown	gnl\|CDD\|223088
CP020645.1\|AWP57752.1\|1482190_1483885_-\|thiamine-pyrophosphate-binding-protein	unknown	unknown	gnl\|CDD\|181285
CP020645.1\|AWP57745.1\|1475161_1476067_+\|agmatinase	unknown	unknown	gnl\|CDD\|212538
CP020645.1\|AWP57750.1\|1480093_1480639_+\|acyl-dehydratase	unknown	unknown	gnl\|CDD\|239538
CP020645.1\|AWP57758.1\|1490785_1493446_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274682
CP020645.1\|AWP57747.1\|1476907_1477600_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
CP020645.1\|AWP57746.1\|1476093_1476885_+\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270248

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP57749.1\|1478502_1480062_+\|acetolactate-synthase-large-subunit	gnl\|CDD\|236063	PRK07586, PRK07586, acetolactate synthase large subunit.	0
CP020645.1\|AWP57753.1\|1484042_1484930_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	1.14336e-66
CP020645.1\|AWP57741.1\|1470634_1471825_+\|5-(carboxyamino)imidazole-ribonucleotide-synthase	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	0
CP020645.1\|AWP57756.1\|1487580_1488693_-\|D-alanyl-D-alanine-endopeptidase	gnl\|CDD\|236952	PRK11669, pbpG, D-alanyl-D-alanine endopeptidase; Provisional.	1.04924e-102
CP020645.1\|AWP57748.1\|1477621_1478374_+\|glutamine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.23529e-151
CP020645.1\|AWP57744.1\|1474132_1474969_+\|transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.50542e-66
CP020645.1\|AWP57754.1\|1484967_1485900_+\|site-specific-tyrosine-recombinase-XerD	gnl\|CDD\|234713	PRK00283, xerD, tyrosine recombinase.	1.37589e-163
CP020645.1\|AWP57757.1\|1489379_1490582_+\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.91228e-73
CP020645.1\|AWP61115.1\|1485913_1486402_+\|aminoacyl-tRNA-deacylase	gnl\|CDD\|237976	cd00002, YbaK_deacylase, This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS) inserted (INS) editing domain. The bacterial amino acid trans-editing enzyme YbaK is a deacylase that hydrolyzes cysteinyl-tRNA(Pro)'s mischarged by prolyl-tRNA synthetase. YbaK also hydrolyzes glycyl-tRNA's, alanyl-tRNA's, seryl-tRNA's, and prolyl-tRNA's. YbaK is homologous to the INS domain of prolyl-tRNA synthetase (ProRS) as well as the trans-editing enzyme ProX of Aeropyrum pernix which hydrolyzes alanyl-tRNA's and glycyl-tRNA's.	9.78705e-67
CP020645.1\|AWP57743.1\|1473018_1474041_+\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270410	cd13692, PBP2_BztA, Substrate bindng domain of ABC glutamate/glutamine/aspartate/asparagine transporter; the type 2 periplasmic binding protein fold. BztA is the periplamic-binding protein component of ABC transporter specific for carboxylic amino acids, glutamine and asparagine. The BZtA domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.2809e-119
CP020645.1\|AWP57755.1\|1486521_1487100_+\|protease	gnl\|CDD\|153243	cd03169, GATase1_PfpI_1, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	1.34539e-109
CP020645.1\|AWP57751.1\|1480917_1482174_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173840	cd01151, GCD, Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.	0
CP020645.1\|AWP61116.1\|1487172_1487574_+\|aryl-sulfate-sulfotransferase	gnl\|CDD\|226771	COG4321, COG4321, Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only].	8.03867e-42
CP020645.1\|AWP57742.1\|1471829_1472882_+\|threonylcarbamoyl-AMP-synthase	gnl\|CDD\|223088	COG0009, SUA5, Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis].	6.96555e-71
CP020645.1\|AWP57752.1\|1482190_1483885_-\|thiamine-pyrophosphate-binding-protein	gnl\|CDD\|181285	PRK08199, PRK08199, thiamine pyrophosphate protein; Validated.	0
CP020645.1\|AWP57745.1\|1475161_1476067_+\|agmatinase	gnl\|CDD\|212538	cd11592, Agmatinase_PAH, Agmatinase-like family includes proclavaminic acid amidinohydrolase. This agmatinase subfamily contains bacterial and fungal/metazoan enzymes, including proclavaminic acid amidinohydrolase (PAH, EC 3.5.3.22) and Pseudomonas aeruginosa guanidinobutyrase (GbuA) and guanidinopropionase (GpuA). PAH hydrolyzes amidinoproclavaminate to yield proclavaminate and urea in clavulanic acid biosynthesis. Clavulanic acid is an effective inhibitor of beta-lactamases and is used in combination with amoxicillin to prevent the beta-lactam rings of the antibiotic from hydrolysis and, thus keeping the antibiotic biologically active. GbuA hydrolyzes 4-guanidinobutyrate (4-GB) into 4-aminobutyrate and urea while GpuA hydrolyzes 3-guanidinopropionate (3-GP) into beta-alanine and urea. Mutation studies show that significant variations in two active site loops in these two enzymes may be important for substrate specificity. This subfamily belongs to the ureohydrolase superfamily, which includes arginase, agmatinase, proclavaminate amidinohydrolase, and formiminoglutamase.	1.51723e-115
CP020645.1\|AWP57750.1\|1480093_1480639_+\|acyl-dehydratase	gnl\|CDD\|239538	cd03454, YdeM, YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.	1.08305e-70
CP020645.1\|AWP57758.1\|1490785_1493446_+\|hypothetical-protein	gnl\|CDD\|274682	TIGR03623, TIGR03623, probable DNA repair protein. Members of this protein family are bacterial proteins of about 900 amino acids in length. Members show extended homology to proteins in TIGR02786, the AddB protein of double-strand break repair via homologous recombination. Members of this family, therefore, may be DNA repair proteins.	0
CP020645.1\|AWP57747.1\|1476907_1477600_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.52172e-80
CP020645.1\|AWP57746.1\|1476093_1476885_+\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270248	cd13530, PBP2_peptides_like, Peptide-binding protein and related homologs; type 2 periplasmic binding protein fold. This domain is found in solute binding proteins that serve as initial receptors in the ABC transport, signal transduction and channel gating. The PBP2 proteins share the same architecture as periplasmic binding proteins type 1, but have a different topology. They are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the family includes ionotropic glutamate receptors and unorthodox sensor proteins involved in signal transduction.	9.69108e-62

>CP020645.1|AWP57750.1|1480093_1480639_+|acyl-dehydratase
MPPRNTRAARLVYPAVLARLGSNGLPAAFQQGRSMKFADLRAGMVITGGPLQVTEAEILEFARKFDPQWFHTDVQRAAEGRWGGLIASGWHTCALAMRMAVDAILHDSESFGSPGLGEVSWRVPVRPGDTLTLHARVQGARVSASRNDLGIVNWAWVVDNQHGETVLELDATSLFDLSGDS
>CP020645.1|AWP57749.1|1478502_1480062_+|acetolactate-synthase-large-subunit
MNGADSLCDTLLANDIDVCFANPGTSEMHFVAALDRKPRMRCVLGLFEGVVTGAADGYARMADKPAATLLHLGPGLGNGLANLHNAKRARTPMVNVVGDHATYHVQYDAPLTSDVEAVAQPMSHWVGRIRDAASVAAQTSEAIQVARQEPGNVSTLILPADAAWTDLPDDTPAPQPVRQAPQAQADAQAIRAAAQAIRSGQATTLLLGGAALRGRALAAAGRIAHATGVRLAAETSSRRTERGANRPPVVRLPYPVDLAVAFLKDVRHLVLVGSRSPVAFFAYPGKPSLLAPQECDQIVLAEPEQDLHHALEWLADELGIPADAPQTRPAALTEAVPAEGRLTSAAVNRVAAALLPDNAIVCDESITQGREFGIYSVHSAPHDWLQLTGGAIGIGLPLATGAAVACPDRKVVLLQADGSGMYTVQALWTQARERLDCLTIIYANRTYATLHGEMKNVGVIQPGENAKRMLDLVDPHIDWVQVSQGLGVEAVRVDTVEGFTQAMRAALARKGPFLIEAVI
>CP020645.1|AWP57748.1|1477621_1478374_+|glutamine-ABC-transporter-ATP-binding-protein
MDACNQPAPVITLRGVSKWYGDFQVLRDLDLDVYQGERVILCGPSGSGKSTTIRLLNRLEEHEKGEIVVNGITLDGELRNIERIRADVGMVFQHFNLFPHLTVLENCTLAPMRVKGLDEGEAARRAMQFLERVRIAQLADKYPGQLSGGQKQRVAIARALCMQPRIMLFDEPTSALDPEMVKEVLDTMVELARDGMTMICVTHEMGFAREVGDRVVFMDGGSIVESDTPERFFSAPRSSRAQAFLGQILG
>CP020645.1|AWP57747.1|1476907_1477600_+|amino-acid-ABC-transporter-permease
MNLETLRMYLTPLAEGTMWTLALFFCSAVLAVALGLLVCLCRLSKSRVLSRGARLYIDIIRGTPLLLQLFYIYYGMPELGVVINAFVAGVLGLTLNFGAYLAELFRSGIQSVDSGQYEAARALGLNKVDRLRRVVLPQAVRTVFPALGNYALVLIKETSLVAVISVYELMRAGEMLAGATFQALTVYTMVGAIYFAMCSVLAHLFRRSEKRLTVPGYWSGAGENHDISKA
>CP020645.1|AWP57746.1|1476093_1476885_+|amino-acid-ABC-transporter-substrate-binding-protein
MKIKAALGILATVGMLAHAGSAAARTLDEVRAAKSANVVTTASAPPHGFKNPASNQLEGIMVDVGAAVAKHLGVAMNLKDVPFSGLIPTLTSGRADVMSAPLFVTPERAKVIDFSAPVYEWGEGLVLREQNPDDIKRFEDLQGRRIGVLVDSVQFNMIKDMPDTKVSTYQDYSTLLADVRAGRIELGIIDPPSIIYQIRTKKIPGVKLATQYQPQKKWHVGLAVQKDNKALLDAVNAALAEMKRNGELAEIGRKWGVADLISK
>CP020645.1|AWP57745.1|1475161_1476067_+|agmatinase
MGVPARRPAGEAALACVLGIPFDCGTHPFRVGARQGPDAIREQSRLLRPYDLARRAGVDNPVEFLRLLDLGNVACVPGDPQASYPAIEQAVAQVLQAGAIPITMGGDGAVTLPQLRAVARRWPGVAVLHFDSHTDTYPIAGYNTATTFTRAAEEGLIDLSHSFHVGTRGNSFMGGVIEYGREVGYTVIPYDDFDRDQAGTLARLRGQLGDRPVYLCFDMDIFDPSCAPGVCTPEWGGLSPKEGLNLLRALSGLNFVAFDVNTVSPPQDVGGATAFLAASVMQEFCALAAAAVQAYPQGRPD
>CP020645.1|AWP57744.1|1474132_1474969_+|transcriptional-regulator
MTTVAPEDSPLFVAALARGLTLLAAFSEGRPAMTLPELAEATGLTKSAAQRFAHTLWTLGYLRKNPDSKKFSLSPQSLQLGMQYAQTSPLVLGGNPFLHSLNRTSQETCSLAEPDGLDMVYVARFATHKQMFVHMPVGMRIPMYCAAAGRAVLARLEPDRARRLLQQSPRAARTATTLTDLDALMAELAFTREHGYARSNGEYYPGDITISAAVLDNAGTPAGSVNISVPSSRWSFEEAQAVFGPQVLETAHAISASRTLGVLPPFYRMAPPSALNSD
>CP020645.1|AWP57743.1|1473018_1474041_+|amino-acid-ABC-transporter-substrate-binding-protein
MKRHIAMAAGALALALGAQAAHAGPTLDAVKKKGFVQCGLTDGVAGFSATNSKGEWEGMDVDICRAVAAAVFGDAGKFKGTALSTQQRFTALQSGEVDVLLRTVTLTQTRDTSLGLAAVAASFYDGQGVLVRKALGVKSAKELDEATICVQPGTTTELNLADWFRANGIKFTPVVIDKVTEVVRAFESGRCDAFTDDASQLAAVRATQVAKPDDFEILPERFSKEPLGPMVRQGDENWLGIVRWTLFALMEAEEYGITQQNVDEMLKSKNPNVLRILGVTPGAGKNMGLDEKWAYNAIKAVGNYSQIFERNVGKDSRLGLQRGVNALWSQGGAMYPWPIR
>CP020645.1|AWP57742.1|1471829_1472882_+|threonylcarbamoyl-AMP-synthase
MIPAAMNAADPAVAHAAACLLAGELAAFPTETVYGLGADAENPQAVARIYAAKGRPSNHPVIVHIAPEGDVDYWASDVPAAARQLIQAFWPGPLTLILKRAPHIGAAVSGGQDSIGIRCPSHPVAQALLRAFAAGKPNGQGGVAAPSANTFGHVSPTRAEHVRAEFPREVAAGMPVLDGGDAEVGIESTIIDLSRLDQGVGPVLLRPGHISAAQVAAVLGMPVARPDAAAPRASGTLKAHYAPRTPLELLDAAQLPRALAAAPAGVRQAVVALAPAPAGLSADVHWRMAPADPARYAQALYALLRELDRQGYARILVEQPPRSGDWDAVNDRIGRAAAAFSLDTTDLPGT
>CP020645.1|AWP57741.1|1470634_1471825_+|5-(carboxyamino)imidazole-ribonucleotide-synthase
MTQSSTFDPIAPGDWLGLLGGGQLGRMFCHAAQSLGYKVAVLDPADECPAGMVADLHIQAAYDDADGLARLAGRCRAVTTEFENVPADSLRALAARCRVSPAADAVAVVQDRIAEKTFIAGQGIEVAPHAAIRARDDLLAAPQALFPGILKVARLGYDGKGQARIASREEALAAFDEFGGVPCVLEALLPLEYEISVVIARGFDGASMVFPIARNVHRDGILAVSSVTPGAADASHAARQVQATQAAQAIAQGLGYHGVLCVEFFVLGDGRLVVNEIAPRPHNSGHYTIDACVTSQFEQQARVMAGLPLGSADLLAPAVMLNILGDAWFEPGAHAPREPDWSAALAVPSAKLHLYGKREARRGRKMGHVTIVAATPEQARDDAARVARALGMAAPF
>CP020645.1|AWP57751.1|1480917_1482174_-|acyl-CoA-dehydrogenase
MPRPHIHDPDLSFSYLHWSTRMSSTPSFHWQDPLLLDQQLTEEERMVRDAAVAYSQDKLAPRVLEAFRHEKTDPAIFAEMGELGLLGATIPTEYGGAGLNYVCYGLIAREVERVDSGYRSMMSVQSSLVMVPINEFGSEAQKRKYLPKLAAGEWIGCFGLTEPNHGSDPGGMETRATKTPDGYKLTGNKMWITNSPIADVFVVWAKCVGGDFDGKIRGFILEKGMKGLSAPAIHGKVGLRASITGEIVMDEVEVSEEQMMPGVSGLKGPFTCLNSARYGIAWGALGAAEACWHTARQYTMDRKQFGRPLAANQLIQKKLADMQTEITLGLQGCLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARLARDMLGGNGISDEFGVARHLVNLEVVNTYEGTHDVHALILGRAQTGLQAFY
>CP020645.1|AWP57752.1|1482190_1483885_-|thiamine-pyrophosphate-binding-protein
MTTANHSTPASRLGGHILVDQLAAHGVKHVFCVPGESYLAVLDGLHDASIDVTVCRQEGGAAMMADAHGKLTGEPGICMVTRGPGASNALAGVHIAKQDSTPMILFVGQIERGMREREAFQEMDYRAVFGTQAKWVTEIDQVERIPELISRAFHVATSGRPGPVVIALPEDVLVETASVPDAPRYEVIDAAPAAGQMDQLAQMLAQARAPVAILGGSRWNAQAVQQFADFAQRHALPTAVSFRRQMLFPADHPCFIGDVGLGINPALLKRIEQADLVLMVGGRMSENPSQAYTLLDIPVPRQKLVHVHPDSAELGRVYRANLAINTSPAAFCAALAQANGPSQPAWADDTQAMRASYLQWSDPAAIRTPGALQLGEVMAFLEKTLPADAIMANGAGNYATWLHRFHRYTRYGTQLAPTSGSMGYGLPAAVGAKRIWPQKTVVCFAGDGCFLMHGQEFATAVQYDLPIVVVLIDNGMYGTIRMHQEKHYPGRISATSLKNPDFAEYARAFGGHGERVETTEQFAPAFERALASGKPAILHCLIDPETITPSTTLEKIRAAALKAQ
>CP020645.1|AWP57753.1|1484042_1484930_+|LysR-family-transcriptional-regulator
MRNGIPNLSALQAFEATARLGSFSRAAEELSLTHSAVYRQVASLEDRLGVQLFTRVRRRIVLTDHGAEYAGRIRHHLDQIEKDTFGLVSRTGMGRSIHIAVVPTLATTWLIPRLADFQRVQPDITVSLSVRTLPFQFKDQPFDGALYHGDGIWPGTQGVLLFPERELVPVCAPELAERASGRDDGALGGMMHLHLYSRPDAWRQWYAANQYAYGPQAAGGPRYDLFTMMLAAVQAGLGVGLMPRFLVQDALDAGTLVMPVPQALSVSQGYYFGYPQRSERSGALKAFEVWLKSAV
>CP020645.1|AWP57754.1|1484967_1485900_+|site-specific-tyrosine-recombinase-XerD
MSSSAPLASQADLDAFIDAVWLEDGLAANTLAAYRRDLSAFAQWLENPACHPGLATGASLREAGKGDIEAWFAARHAESRATTANRRLAALRRFYAWALRERLTPSDPCLTLVTAKQPPRLPKTLSEAQVDALLQAPDLDTARGLRDRAMLETLYATGLRVSELVSVKALDVSLNEGVVRVVMGKGGKDRLVPLGAEAAHWIERYAGSARPELLGARVADALFVTARAEPMSRQAFWQLVKKYALAADIHAPLSPHVLRHAFATHLLNHGADLRVVQMLLGHADISTTQIYTHVARERLKALHAAHHPRA
>CP020645.1|AWP61115.1|1485913_1486402_+|aminoacyl-tRNA-deacylase
MSKNRHVSETPATQLLRQRKVAFTEHTYDYVDHGGAGEAARQLGLDPHAVVKTLIMEDEGGHPLVVLMHGDREVSTKNLARQAGLKKVAPCQPEVAQRHSGYQVGGTSPFGTRKRMPVWVEASVLDFPQIYVNGGRRGYLVGIAPQALVDLLGARAVQVALP
>CP020645.1|AWP57755.1|1486521_1487100_+|protease
MSKKLLMLVGDYAEDYETMVPFQTLLAVGHTVHAVCPDKKAGDTVATAIHDFEGAQTYSEKRGHNFTLNHDFAKVEPQHYDGLVIPGGRAPEYLRLDERVLDIVRHFDQAGKPIAAVCHGAQLLAAAGILQGRTCSAYPACAPEVRLAGGTYAEIGIDQAHTDGNLVTAPAWPAHPAWLAQFLAVLGTRISH
>CP020645.1|AWP61116.1|1487172_1487574_+|aryl-sulfate-sulfotransferase
MSCINRVPGILMCEIFIRANQRSYSVQARSLRLHGVATSVRLEQLFWDVLEEIAARDGMRVTQLIERLYDELVQYRGEAANFTSFLRVCCLRYQVLQAEGRIPADATVPIRSLDAQAVLRGLPANLYDSRPLG
>CP020645.1|AWP57756.1|1487580_1488693_-|D-alanyl-D-alanine-endopeptidase
MAFHWTRAVARALAPLALAIGALLPYAAHAAKADPCRTNAKSAACKSQQAKKASAKKAPAKTASSKKSASTAKKKSASSKKTASAKKGSTRKSTIRARTRTARASAAATAAMPPAAASPAAEAAALRSSTAYVQDLETSTVLFAKNENVVRPIASISKLMTALVVVDANLPMDEMIEITDDDVDTLKHTTSRLRVGTVLSRGDMLHLALMSSENRAAHALGRNYPGGMPAFVAAMNAKARSLGMLNTRFVEPTGLSSENVSSPRDLARMLRAASQRPLIHRYSTDTEYEVEINNRTQTFRNTNLLVRKPDWDIKVSKTGFINEAGECLVMLARINGRDMAIVLLDSQGKLSRIGDAVRIRRIVQNDVAML
>CP020645.1|AWP57757.1|1489379_1490582_+|MFS-transporter
MSTSEKPSLRILFIGTGVVLLAMGVRATFGLFMQPMGLAHGWGREVFSMAFALQNLVWGAACIGMGILADRYGSGRTIVLGAVLYALGMIGTRFATDEATLYLTAGVLVGLGQAGTTFPVILPVVARSVPAAYRSTAMGIASAGGSLGQFLVVPAGQQLITGLDWPGALWVLSLLVAVGAPLAYFLRGKPGVHGGVQQSLGAAVRQAMAHPSFHFLSWSYFVCGFHTAFITLHLPAYVVDAGMKASHGATAIALIGLCNVIGSFYAGKLGGVYSKRLLLAAIYGLRAFGMLLLLAVPLTPLVLYVFAGWMGLFWLGTVPLTQGLIGQIYGLRYAATLSGIAFLGHQVGSFIGVWMGGAVYARTGNYDLVWWTGVALAVVAALLCLPVREQPLAQPAAARA
>CP020645.1|AWP57758.1|1490785_1493446_+|hypothetical-protein
MSDDFRTDFPSCTLRDLGELPAIDTLVLTVNNRLSRRLTLDLAAQLRSERQVSELPRIMPLSAWLADCAAELAFDERYEVPAYRLSSFATQLVWREAIRLEEADRALLDADQAARLALDADLLVDEWQAHVPAGAETDEYRGFSRWRARYRAMLGELDAEDANQGYERVLEALRQGALRAPRHVALAGFVDISPRFARLLRALADGGADVVAWRDAVREPAWPQRFEAADRGAEWRAAARWAADRLRADPRGRYAIVSPQLEAEAPFARRVLGQALAGQDAPLPFNVAVGRALDEWPAVRAALAWLALLAEVAARGAGEPALFGAALLAGHCAGDLQEGPRHAALDARWRRQALAHVGPADWQRGLEECPRLAEGWSQAMEIWQAGQRSDTCDAWAPRFKAALTALGFPGERALDSVAYQVMGALGDLLAEFTALAPAAGRLDGRAAVRLLASAARAGSFQPQRDPSARLDVLGLLEAEGGAWDGIWVLGLTDDVLPASPKPNPLLPLAVLRQVGAPRATPEREREWAEGMFMALRRCAPEMIASHAAMDGERELRPSPLIARAAPADWQPGADAQAAALEQEILDDSQGPPLQAERQSRGGLDVLDTQARNPLWAFVRHRLGGRAMAPYADAATVSVRGQFLHRALELVWRMLPDQEALHAAMAEGRLAALVEQAIGEAARTELAGYPAALRELECARAAAVLANWFDSEAQRQPFEVAQIEQEHSWQRGALALKVRLDRMDRLADGRALIVDYKTGAAPGRPESDWARARPVNLQLPFYASVLADGADTEVAGLMLAQIHARQVSAQGLAADDLGIEGVTPVEQSKAFEGQPWPRILQRWRAAVEMLADEYANGYAANVALRQDDLKFCDAMPFLRLHLDDEDA

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Crispr_ID: CP020645_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_7

1759436-1759535

Orphan

Consensus_repeat	Method
GGACAGGCACCTGCGACCGAGCCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_7

>merge|CP020645|7|1759436-1759535|CRISPRCasFinder
GGACAGGCACCTGCGACCGAGCCACGTCACCCGACATCCCATCGGCACAGCCCCGCCCGGTGCCTGTCCCCGCCGGGACAGGCACCTGCAACCGAGCCAC

>CP020645|7|7|1759436-1759535|CRISPRCasFinder
GGACAGGCACCTGCGACCGAGCCAC	GTCACCCGACATCCCATCGGCACAGCCCCGCCCGGTGCCTGTCCCCGCCG
GGACAGGCACCTGCAACCGAGCCAC

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP57993.1\|1751274_1752051_-\|UDP-2,3-diacylglucosamine-diphosphatase	unknown	unknown	gnl\|CDD\|235420
CP020645.1\|AWP57996.1\|1755081_1755726_+\|DNA-3-methyladenine-glycosylase	unknown	unknown	gnl\|CDD\|223200
CP020645.1\|AWP58007.1\|1765093_1765897_+\|aspartate-dehydrogenase	unknown	unknown	gnl\|CDD\|106261
CP020645.1\|AWP57999.1\|1757895_1759188_+\|aspartate-kinase	unknown	unknown	gnl\|CDD\|235843
CP020645.1\|AWP58006.1\|1764287_1765097_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|211851
CP020645.1\|AWP58001.1\|1760221_1760536_+\|NIPSNAP-family-protein	unknown	unknown	gnl\|CDD\|311781
CP020645.1\|AWP58003.1\|1761483_1762008_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377284
CP020645.1\|AWP57992.1\|1750207_1751071_+\|undecaprenyl-diphosphatase	unknown	unknown	gnl\|CDD\|234712
CP020645.1\|AWP57994.1\|1752681_1753365_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276809
CP020645.1\|AWP57998.1\|1756788_1757823_+\|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl\|CDD\|238950
CP020645.1\|AWP58004.1\|1762010_1763279_+\|C4-dicarboxylate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224509
CP020645.1\|AWP58009.1\|1766766_1767405_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
CP020645.1\|AWP58008.1\|1765911_1766679_+\|short-chain-dehydrogenase	unknown	unknown	gnl\|CDD\|235712
CP020645.1\|AWP58002.1\|1760545_1761487_+\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|235706
CP020645.1\|AWP57997.1\|1755762_1756728_+\|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
CP020645.1\|AWP57995.1\|1753604_1755062_+\|cysteine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234705
CP020645.1\|AWP61126.1\|1752043_1752553_-\|cyclophilin	unknown	unknown	gnl\|CDD\|182734
CP020645.1\|AWP57991.1\|1748596_1750183_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223930
CP020645.1\|AWP58005.1\|1763307_1764291_+\|C4-dicarboxylate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270321
CP020645.1\|AWP58000.1\|1759679_1760180_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380396

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP57993.1\|1751274_1752051_-\|UDP-2,3-diacylglucosamine-diphosphatase	gnl\|CDD\|235420	PRK05340, PRK05340, UDP-2,3-diacylglucosamine hydrolase; Provisional.	2.04318e-114
CP020645.1\|AWP57996.1\|1755081_1755726_+\|DNA-3-methyladenine-glycosylase	gnl\|CDD\|223200	COG0122, AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair].	4.52687e-55
CP020645.1\|AWP58007.1\|1765093_1765897_+\|aspartate-dehydrogenase	gnl\|CDD\|106261	PRK13301, PRK13301, putative L-aspartate dehydrogenase; Provisional.	2.99901e-157
CP020645.1\|AWP57999.1\|1757895_1759188_+\|aspartate-kinase	gnl\|CDD\|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	0
CP020645.1\|AWP58006.1\|1764287_1765097_+\|alpha/beta-hydrolase	gnl\|CDD\|211851	TIGR03611, RutD, pyrimidine utilization protein D. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the hydrolase, alpha/beta fold family defined by pfam00067.	8.34617e-38
CP020645.1\|AWP58001.1\|1760221_1760536_+\|NIPSNAP-family-protein	gnl\|CDD\|311781	pfam07978, NIPSNAP, NIPSNAP. Members of this family include many hypothetical proteins. It also includes members of the NIPSNAP family which have putative roles in vesicular transport. This domain is often found in duplicate.	7.86859e-37
CP020645.1\|AWP58003.1\|1761483_1762008_+\|hypothetical-protein	gnl\|CDD\|377284	pfam04290, DctQ, Tripartite ATP-independent periplasmic transporters, DctQ component. The function of the members of this family is unknown, but DctQ homologs are invariably found in the tripartite ATP-independent periplasmic transporters.	2.28017e-25
CP020645.1\|AWP57992.1\|1750207_1751071_+\|undecaprenyl-diphosphatase	gnl\|CDD\|234712	PRK00281, PRK00281, undecaprenyl-diphosphate phosphatase.	8.52893e-109
CP020645.1\|AWP57994.1\|1752681_1753365_-\|hypothetical-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.46032e-10
CP020645.1\|AWP57998.1\|1756788_1757823_+\|tRNA-lysidine(34)-synthetase-TilS	gnl\|CDD\|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	3.18654e-63
CP020645.1\|AWP58004.1\|1762010_1763279_+\|C4-dicarboxylate-ABC-transporter-permease	gnl\|CDD\|224509	COG1593, DctQ, TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism].	1.5449e-125
CP020645.1\|AWP58009.1\|1766766_1767405_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.42874e-07
CP020645.1\|AWP58008.1\|1765911_1766679_+\|short-chain-dehydrogenase	gnl\|CDD\|235712	PRK06138, PRK06138, SDR family oxidoreductase.	4.5213e-117
CP020645.1\|AWP58002.1\|1760545_1761487_+\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|235706	PRK06129, PRK06129, 3-hydroxyacyl-CoA dehydrogenase; Validated.	9.737e-146
CP020645.1\|AWP57997.1\|1755762_1756728_+\|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
CP020645.1\|AWP57995.1\|1753604_1755062_+\|cysteine--tRNA-ligase	gnl\|CDD\|234705	PRK00260, cysS, cysteinyl-tRNA synthetase; Validated.	0
CP020645.1\|AWP61126.1\|1752043_1752553_-\|cyclophilin	gnl\|CDD\|182734	PRK10791, PRK10791, peptidylprolyl isomerase B.	5.87344e-90
CP020645.1\|AWP57991.1\|1748596_1750183_+\|hypothetical-protein	gnl\|CDD\|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	4.32604e-97
CP020645.1\|AWP58005.1\|1763307_1764291_+\|C4-dicarboxylate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270321	cd13603, PBP2_TRAP_Siap_TeaA_like, Substrate-binding domain of a sialic acid binding Tripartite ATP-independent Periplasmic transport system (SiaP) and related proteins; the type 2 periplasmic-binding protein fold. This subfamily includes the periplasmic-binding component of TRAP transport systems such as SiaP (a sialic acid binding virulence factor), TeaA (an ectoine binding protein), and an uncharacterized TM0322 from hyperthermophilic bacterium Thermotoga maritima. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.15079e-96
CP020645.1\|AWP58000.1\|1759679_1760180_+\|hypothetical-protein	gnl\|CDD\|380396	cd06991, cupin_TcmJ-like, TcmJ monooxygenase and related proteins, cupin domain. This family includes TcmJ, a subunit of the tetracenomycin (TCM) polyketide synthase (PKS) type II complex in Streptomyces glaucescens. TcmJ is a quinone-forming monooxygenase involved in the modification of aromatic polyketides synthesized by polyketide synthases of types II and III. Orthologs of TcmJ include the Streptomyces BenD (benastatin biosynthetic pathway), the Streptomyces olivaceus ElmJ (polyketide antibiotic elloramycin biosynthetic pathway), the Actinomadura hibisca PdmL (pradimicin biosynthetic pathway), the Streptomyces cyaneus CurC (curamycin biosynthetic pathway), the Streptomyces rishiriensis Lct30 (lactonamycin biosynthetic pathway), and the Streptomyces WhiE II (spore pigment polyketide biosynthetic pathway). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.05427e-15

>CP020645.1|AWP57999.1|1757895_1759188_+|aspartate-kinase
MRACQPEYEMSLIVQKYGGTSMGSVERIKNVARRVAKWHAAGHKVVVVPSAMAGETNRLLSLAREISPQPDGRELDMIAATGEQASSGMLAIALQAEGVPARSYAGWQVPVRTDSSYTKARIKSIDDKRVLADLDAGRVVIVTGFQGVDDDGHITTLGRGGSDTSAVAVAAAIKADECLIFTDVDGVYTTDPRVVPEARRMAVVSFEEMLEMASLGSKVLQIRSVEFAGKYHVPTRVLSSLTDPLIPLEEEMRSGTLITFEEDEKMEAAVVSGIAFSRDEAKITLLAVPDKPGIAYSILGPVAAANIDVDMIVQNQSVAGTTDFSFTVNRNEYQRTLDLLKREVIPAVSARELVTDEKVAKVSIVGIGMRSHVGVASLMFQTLSQEGINIQMISTSEIKTSVIIDDKYMELAVRSLHKAFGLDQVPGDQV
>CP020645.1|AWP57998.1|1756788_1757823_+|tRNA-lysidine(34)-synthetase-TilS
MSTSPAAPAPSLSDLCPAALRRPVAAALRALDPAPARLAVAVSGGADSAMLAVAAAAALPPGCTLRLFHVHHGLQAAADQWAAQVRGLGALLGVPVDEARVTVPPGQGLGMEAAARLARYQALAGLARQHGVRHILLAHHRNDQAETVLLRLLRGTGLQGMAAMAPFSERDGVAYLRPWLDVDRAAILALAGAVRAQRGWQAVQDPTNTDPRYARAAVRTQLAPALDARWPGWQAIVARHARQMAEAAEIVAEVARADFATLEPADAGRSFSLAAWRGLSAARQAQALRHWLAGQDAPMPTEARLAELQRQLRQLHALGHDRHLRWQHAGRVVRCERGRVWIDD
>CP020645.1|AWP57997.1|1755762_1756728_+|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-alpha
MRNTFLEFEQPLAELENKIEQLRYVQADSAVDISDEIGRLQQKSQNLAKEIYGKLTPWQTALVARHPQRPYTLDYVREIFTDFHELHGDRMYADDQSIVGGLARFNGSACMVIGHQKGRDTKERAARNFGMPRPEGYRKALRLMRLAEKFRLPIFTFIDTPGAYPGIGAEERGQSEAIGRNLYAMAELKVPVICTVIGEGGSGGALAIAVGNAVLMLQYATYSVISPEGCASILWRSADKAPEAAEALAITAPRLKDLGLVDRVVNEPVGGAHRDPRVMARLLRRALGDALRQLQGLGPEQLVDQRLQRLMSYGRFQEVRA
>CP020645.1|AWP57996.1|1755081_1755726_+|DNA-3-methyladenine-glycosylase
MSSADIVIVKPEYWDDAVAHLMRRDRILKRIIPQHGETWLTSRGSPFVTLARAIIGQQISVKAADALWQRFLETVGKRPTPATVLRAGVPALRAAGLSQRKAEYLVDLATHFGQRLVHPEKWAAMDDEAVIAELVAIRGIGRWTAEMFLIFNLQRPDVLPLDDLGLLKAISLHYFSGEPVSRFEAREVSLAWQPWRTVATWYLWRSLEPAAVQY
>CP020645.1|AWP57995.1|1753604_1755062_+|cysteine--tRNA-ligase
MLHIYNTLSRTKEPFKPAHAGQVRMYVCGMTVYDYCHLGHARMLVAFDVVQRWLRASGLAVDYVRNITDIDDKIIRRAVETGRRIGEVTEYYIAAMHADERALGVQRPDREPRATQYVGEMLDIIGRLESKGLAYRAEDGDVNYAVRGFADYGKLSGKSLDDLRAGERVAVGSAKRDPLDFVLWKSAKPQEPDDTKWESPYGLGRPGWHIECSAMSKTLLGLPLDIHGGGPDLKFPHHENEIAQTEGAFGGALANVWMHCGPLMVDADKMSKSLGNFRTIRQTIAQGPLSDTQAEYAVNPREAEMLRFFIVRNHYRSPQNYAPDNLVDAQNALDRLYQALQNTAADGQGVDWSEPQAQAFKAAMDDDFNSSGAVAALFELASEANRTGSARAAGQLKALGAVLGLLQQDPPAYFQSPTRYSAAARGQGAPAAALDAAAIEARIAERAAAKAARDFARADAIRAELRAAGIELDDRPGGLTQWRRA
>CP020645.1|AWP57994.1|1752681_1753365_-|hypothetical-protein
MTTKPRLCTALLTLAIAVSASAPVLAQSMAGGSAKNRYANQTKLDPYPPEGGWQGLANLLEAAKPGVDTRLDPTPSQITDRIEELLNRGANEEALSLIERREAAIKGQRGADVQLMFQHARALAALGRADEAIAVYSDMTNQFPELPEPWNNLAALYASRGELERAQDSLQMALRANPDYAAARANLGDIQLMMALRTYRQEAARGVPGMKARVEEIESLLKDKQPK
>CP020645.1|AWP61126.1|1752043_1752553_-|cyclophilin
MSTNPRVKLHTNQGDIIITLNAEKAPKSVENFVAYTKDGFYDGTVFHRVIDGFMIQGGGFEPGMKQKPTKAPIENEANNGLKNDKYTLAMARTSDPHSATAQFFINVSDNDFLNFTAPTPNGWGYAVFGVVTEGTEVVDKIKNVKTGNRGFHQNVPAEDVIIEKAEVLE
>CP020645.1|AWP57993.1|1751274_1752051_-|UDP-2,3-diacylglucosamine-diphosphatase
MNKLALQGPLWLASDLHLGPATPATAEAFLGLLQAAADEASALLLPGDIFDAWIGDDVIRAAPPWLAAVLQGIRAAAGRIPVYLGRGNRDFLIGQELADALGAHLLPEPVLLETDYGRILLTHGDEYCTDDSAYQQFRAMVRNPQWQAQFLAKSIPERLAMAEQARGESQAANQAKSMEIMDVNPAAVEAALREADVDVLVHGHTHRPARHVLSVDGRKRERWVLPDWDCDHADPPRGGWLVIDRDGLQCFDLVEDED
>CP020645.1|AWP57992.1|1750207_1751071_+|undecaprenyl-diphosphatase
MTDSTLHLLKAFFLGIVEGLTEFIPVSSTGHLIVIGDWINFASSSGKVFEVVIQFGSILAVMWIFRARLWQLIRGTLTGVRQEVNFTRNLLLAFLPAAVIGAIFIKSIKQVFYHPGVVAVTLVVGGFIMLWVERRAPHTPGDAPGAADDTASDERATAHTLEQISAKQALGVGVAQCVAMIPGVSRSGATIIGGMIAGIQRKTATEFSFFLAMPTMLGAAVYDLYRNIGLLSQHDMSAIAVGFVAAFLSALVVVRAVLRFVANHTYRVFAWYRIALGLVVAAWIYAK
>CP020645.1|AWP57991.1|1748596_1750183_+|hypothetical-protein
MEWLQDPAAWVGLLTLVVLEIVLGIDNLIFIAILADKLPPAQRDRARIVGLSLALLMRLGLLSVMSWLVTLTTPWFSVGPMSFSGRDLILMLGGLFLLFKGTMELHERIEGGQSLDTGGPRVYASFWVIVTQIVVLDAVFSLDSVITAVGMVDHLAIMMIAVIIAIGIMLLASKPLTRFVNAHPTVVVLCLGFLLMIGFSLLAESFGFKVPKGYLYAAIGFSVAIEALNQVARRNLLKLDARRPMRERTATAVLRMLGKRPPASDESDLPSAMPAVPAFGVEERNMVSGVLTLAERSIRSIMTPRTDVSWVNIDDDAATIRQQLTAAPHSFFPVCRGSLDEVVGIGRAKDLVADLITEGRVRRNRLRDPIIVHESIGILRLMDTLKRSRGQLVLVADEFGAIEGLVTPIDVFEAIAGEFPDEDELPDIVAESENVWKVDGAADLHHLEQVLEIEGLIDESEDYSTLAGYLLARFGHLPKPGDTCEFEGSHHRRVRFEVLQMDGRRVALVRVERLPYDTVDESEAADAD
>CP020645.1|AWP58000.1|1759679_1760180_+|hypothetical-protein
MKQQHEPGIAVVVGPDEGDSFWQPVPANGFVRTLLNRANTGASVDFSAGTQTVAPGCHVREHFHDDREEVIFITEGTGTALIDGVEHPLAPGACLFLGKSRKHSFLNAGPEPLSFFWILMPGGLDDFFRQIGRVRQPGEPAPQPFARPADIDRIEANTVFGWTAKS
>CP020645.1|AWP58001.1|1760221_1760536_+|NIPSNAP-family-protein
MFIEERDYRIKPGKAGLFVATYEAHGLALQKKYLGRFLGYFMSEIGELNHVVAWWAYDSLDERDAARSRMLADPQWQAYLERVTDLIDLQQTRILKPVSFSPIQ
>CP020645.1|AWP58002.1|1760545_1761487_+|3-hydroxyacyl-CoA-dehydrogenase
MNHVAVIGGGIIGASWAVVFARRGLEVTIVERDAACLAGLPARLAGMIERSASLLRAGEQPGDVAARIGATDALAAAVGRADYVQEAVSENLALKRTLFAELDALAPAHALLASSTSTYGASQFTEALAGRARCLVAHPMTPPHLSPVVEMAASAWTDPQALAGAETFMRSLGQHPVRIRKEIPGFVLNRLQGALLMEMFRVIADDVISPADADALISQGLGLRWATLGPLEGVDLNAPGGIADYLQRYGHIFNDMAAGQGLPAPVDAELISALDGAMRAALPLERLEAKRGWRDRAIAGVRVALHDYTGEKP
>CP020645.1|AWP58003.1|1761483_1762008_+|hypothetical-protein
MKLIRAVDGLNRLACWLMAGLMLGMTLCTLWQVSVRFLLTGLGWNVAAPWSEEVSRYLMIWIIFLGAGVACRKAQLIALELVVTLLPAPLGRALRFAALLGCLVFFTLMIYLGLEFMEFGAIETSPVLSMPKTWIYLAMPVGFGLMFLNTATLIAECLLQGIDIRHASQQEAQE
>CP020645.1|AWP58004.1|1762010_1763279_+|C4-dicarboxylate-ABC-transporter-permease
MLSAVVLLLLLFAASIPVALSLGIAPLPALLARDVPLLAVPQTMFESMDSFALMAVPFFVLAGRLMQTGGIAGRLMDLGLALIGWVKGGLGGAAVLTTMFFSTICGSSSATTAAIGSVMIPEMERRGYPRPFAASVVASSGELGVILPPSVPMIIYAMLTGTSVAQMFVAGILPGLLIGLSLIITILIMSRLGDYGGSQRVSVGEWALNVWRALRRASLSLLMPVIILGGIYGGLFTATEAAVVAVAYTFVVSVFIYREIKWKDLPEIFWSSAVTSGIVLLIVGFASVFAYVLSLYQAPQQVAALLLGVSDNPLVFLLLVNIALLVVGLFMETFAAILILAPVLAPVAVSLGIDPVHFGLIVIVNLAVGMVTPPVGVNLFLVCGIARVSMERLMRPLSVFLGVLLLDLIIITYGPVLYARFF
>CP020645.1|AWP58005.1|1763307_1764291_+|C4-dicarboxylate-ABC-transporter-substrate-binding-protein
MNVVKSLFAALALAGASFGASAEPIQINIGHALGDTSSYQVAGLHFAELMKQKVGDKVKVTLYPSGGLGGELKLVQGARTGVVDAMIIAQASLENTVREYRVLSLPYLFTDYEEANRIMQGPVGDRLLDVLPKYNMVGLGWGAVYARSLASMKPVPDLAAMKGLKVRVIQSPGFVEAYRALGSQPTPTAYAELFLSLQNGVVDAAELSPDQTVADGFAEVIKYYSVTAAHQLPSLFIISKAKFDRLPEDVRKAVEEAGRESMQVAVKFQDQKLAEAFDVLKQRGVQVQYPDQAPLREAARGAWDQIAKAAPGGEQFLVEIEAARAAK
>CP020645.1|AWP58006.1|1764287_1765097_+|alpha/beta-hydrolase
MIRQRMTDFTVILPDGARLAARETGAGEAVLLVSGLGGTGAFWTPVAAGLQGRRCVMFDQRGVAGSTRGDAAVDIARLAADAWAVLDARGIERAHLVGHSTGGCIVQEMALSAPARAASLVLGGTWGGRNAYMQSLFAMRAALLAASPALYEQAGAYLSYPAAWLLAHPEAVPAAAAPWPAQRVAVVRERIAALLAYDRLDDLPGLDAPALVLGARDDQIVPFALQQQLARVLPGAQLRPLEHGGHFFPIVRGADYVAALLDWFGHHSL
>CP020645.1|AWP58007.1|1765093_1765897_+|aspartate-dehydrogenase
MTHRIAFIGLGAIASDVAAGLLADAAQPCQLAALTRNAADLPPALAGRVALLDGLPGLLAWRPDLVVEAAGQQAIAEHAEGCLTAGLDMIICSAGALADDALRARLIAAAEAGGARIRVPAGAIAGLDYLQAVAGRDDAEVVYESRKPVAAWRAELPGMGIDPDTLAESRTLFSGPAREAALRFPKNLNVAATLALAGIGMTRTRVEVVVDPQARGNQHRIQVRSPLGEMQIELVNAPSPANPKTSWLVAQSVLATIRRHLARFTIG
>CP020645.1|AWP58008.1|1765911_1766679_+|short-chain-dehydrogenase
MTQRLSGRIAIVTGAGSGIGEATARLMAREGAVVVVADKAIEAAERVAQAIVAEGGRAEARQADVGEAQSVRALVDAVAARWERIDVLVNNAGYGIAATVVDTDEADWSALMRVNVDGVFLGCKYVIPIMQRQGAGVIVNTASAGALVGLRQRAAYCASKGAVAALTRAMALDHATEGIRINCVAPGTIESPYFREIYARSDDPEALRASLAARQPMNRLGQPEEVARAIVFLASDDASFATGSTLVLDGGLTAA
>CP020645.1|AWP58009.1|1766766_1767405_+|TetR-family-transcriptional-regulator
MKATPAQVPMKERIKEVATDMLIAHGSSGFRFQQIAQALDCTRGNIHYHYRHKHELVEDVTIEYCQRTIGHFDQIWLSDSTLSQKIQLSMQFNEMRYLKRNPQGDTSHPWSLIARMRLESALITPAAREALARYSHELQRSVVAGVRRAVEKGELRPDTPVEMVALPIIEMANSADPITRDAGRFDRLRQMYQAVDRLIHDAYGMAGHRPAP

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Crispr_ID: CP020645_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_8

2252979-2253064

Orphan

Consensus_repeat	Method
CTGTCCCCGCCGGGACAGGCACAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_8

>merge|CP020645|8|2252979-2253064|CRISPRCasFinder
CTGTCCCCGCCGGGACAGGCACACCGCGCTACGCCATGAACGGTTGACTGCCAAGACGGTATCTGTTCCCGCCGGGACAGGCACAC

>CP020645|8|8|2252979-2253064|CRISPRCasFinder
CTGTCCCCGCCGGGACAGGCACAC	CGCGCTACGCCATGAACGGTTGACTGCCAAGACGGTAT
CTGTTCCCGCCGGGACAGGCACAC

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP58424.1\|2261844_2262933_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226359
CP020645.1\|AWP58420.1\|2257500_2258190_+\|type-1-glutamine-amidotransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|153235
CP020645.1\|AWP58416.1\|2253996_2254941_+\|dihydrodipicolinate-synthase-family-protein	unknown	unknown	gnl\|CDD\|188630
CP020645.1\|AWP58408.1\|2248146_2248947_+\|aldolase	unknown	unknown	gnl\|CDD\|180832
CP020645.1\|AWP58406.1\|2246664_2247138_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|179596
CP020645.1\|AWP58422.1\|2259848_2260658_-\|DeoR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182827
CP020645.1\|AWP58421.1\|2258204_2259809_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|223651
CP020645.1\|AWP58409.1\|2249001_2250093_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270400
CP020645.1\|AWP58417.1\|2254979_2255951_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270296
CP020645.1\|AWP58405.1\|2244622_2246668_-\|fusaric-acid-resistance-protein	unknown	unknown	gnl\|CDD\|377393
CP020645.1\|AWP58414.1\|2252537_2252912_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226211
CP020645.1\|AWP58411.1\|2250586_2251219_-\|7-carboxy-7-deazaguanine-synthase	unknown	unknown	gnl\|CDD\|275301
CP020645.1\|AWP58412.1\|2251329_2251746_+\|aminoacyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|181730
CP020645.1\|AWP58423.1\|2260762_2261845_+\|ABC-transporter	unknown	unknown	gnl\|CDD\|226359
CP020645.1\|AWP58413.1\|2251738_2252431_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378345
CP020645.1\|AWP58419.1\|2256537_2257419_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377554
CP020645.1\|AWP58410.1\|2250114_2250558_-\|6-carboxytetrahydropterin-synthase-QueD	unknown	unknown	gnl\|CDD\|376501
CP020645.1\|AWP58418.1\|2256041_2256479_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379297
CP020645.1\|AWP58407.1\|2247390_2248011_-\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380339
CP020645.1\|AWP58415.1\|2253091_2253901_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP58424.1\|2261844_2262933_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|226359	COG3839, MalK, ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism].	1.64266e-119
CP020645.1\|AWP58420.1\|2257500_2258190_+\|type-1-glutamine-amidotransferase-domain-containing-protein	gnl\|CDD\|153235	cd03141, GATase1_Hsp31_like, Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein. Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein (EcHsp31). This group includes EcHsp31 and Saccharomyces cerevisiae Ydr533c protein. EcHsp31 has chaperone activity. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. EcHsp31 coordinates a metal ion using a 2-His-1-carboxylate motif present in various ions that use iron as a cofactor such as Carboxypeptidase A. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1 domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For EcHsp31, this Cys together with a different His and, an Asp (rather than a Glu) residue form a different catalytic triad from the typical GATase1 domain. For Ydr533c a catalytic triad forms from the conserved Cys together with a different His and Glu from that of the typical GATase1domain. Ydr533c protein and EcHsp31 are homodimers.	3.27534e-99
CP020645.1\|AWP58416.1\|2253996_2254941_+\|dihydrodipicolinate-synthase-family-protein	gnl\|CDD\|188630	cd00408, DHDPS-like, Dihydrodipicolinate synthase family. Dihydrodipicolinate synthase family. A member of the class I aldolases, which use an active-site lysine which stabilizes a reaction intermediate via Schiff base formation, and have TIM beta/alpha barrel fold. The dihydrodipicolinate synthase family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2'-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase (NAL) family.	6.63687e-70
CP020645.1\|AWP58408.1\|2248146_2248947_+\|aldolase	gnl\|CDD\|180832	PRK07090, PRK07090, class II aldolase/adducin domain protein; Provisional.	6.37491e-166
CP020645.1\|AWP58406.1\|2246664_2247138_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|179596	PRK03573, PRK03573, transcriptional regulator SlyA; Provisional.	5.11244e-19
CP020645.1\|AWP58422.1\|2259848_2260658_-\|DeoR-family-transcriptional-regulator	gnl\|CDD\|182827	PRK10906, PRK10906, DeoR/GlpR family transcriptional regulator.	2.996e-88
CP020645.1\|AWP58421.1\|2258204_2259809_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|223651	COG0578, GlpA, Glycerol-3-phosphate dehydrogenase [Energy production and conversion].	4.74737e-157
CP020645.1\|AWP58409.1\|2249001_2250093_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270400	cd13682, PBP2_TRAP_alpha-ketoacid, Substrate-binding component of an alpha-keto acid binding Tripartite ATP-independent Periplasmic transporter and related proteins; contains the type 2 periplasmic-binding protein fold. This subgroup includes TRAP transporters that bind to ketoacids such as pyruvate and alpha-ketobutyrate, xylulose, and other unknown ligands. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.81983e-167
CP020645.1\|AWP58417.1\|2254979_2255951_+\|hypothetical-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	2.30432e-133
CP020645.1\|AWP58405.1\|2244622_2246668_-\|fusaric-acid-resistance-protein	gnl\|CDD\|377393	pfam04632, FUSC, Fusaric acid resistance protein family. This family includes a conserved region found in two proteins associated with fusaric acid resistance, FusC from Burkholderia cepacia and fdt-2 from Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.	1.65628e-173
CP020645.1\|AWP58414.1\|2252537_2252912_+\|hypothetical-protein	gnl\|CDD\|226211	COG3686, COG3686, Predicted membrane protein [Function unknown].	8.27238e-19
CP020645.1\|AWP58411.1\|2250586_2251219_-\|7-carboxy-7-deazaguanine-synthase	gnl\|CDD\|275301	TIGR04508, queE_Cx14CxxC, 7-carboxy-7-deazaguanine synthase, Cx14CxxC type. In the pathway of 7-cyano-7-deazaquanine (preQ0) biosynthesis, the radical SAM enzyme QueE is quite variable. This model describes a variant form in which the three-Cys motif that binds the signature 4Fe-4S cluster takes the form Cx14CxxC, as in Burkholderia multivorans ATCC 17616. The crystal structure is known.	4.02676e-136
CP020645.1\|AWP58412.1\|2251329_2251746_+\|aminoacyl-tRNA-hydrolase	gnl\|CDD\|181730	PRK09256, PRK09256, aminoacyl-tRNA hydrolase.	1.24352e-65
CP020645.1\|AWP58423.1\|2260762_2261845_+\|ABC-transporter	gnl\|CDD\|226359	COG3839, MalK, ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism].	5.09179e-108
CP020645.1\|AWP58413.1\|2251738_2252431_+\|hypothetical-protein	gnl\|CDD\|378345	pfam09997, DUF2238, Predicted membrane protein (DUF2238). This domain, found in various hypothetical bacterial proteins, has no known function.	1.33959e-64
CP020645.1\|AWP58419.1\|2256537_2257419_-\|hypothetical-protein	gnl\|CDD\|377554	pfam05742, TANGO2, Transport and Golgi organisation 2. In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation. In plants this family includes Solanum habrochaites Cwp, which is involved in water permeability in the cuticles of fruit. Mouse Tango2 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.	5.33506e-86
CP020645.1\|AWP58410.1\|2250114_2250558_-\|6-carboxytetrahydropterin-synthase-QueD	gnl\|CDD\|376501	pfam01242, PTPS, 6-pyruvoyl tetrahydropterin synthase. 6-Pyruvoyl tetrahydrobiopterin synthase catalyzes the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits.	2.78822e-38
CP020645.1\|AWP58418.1\|2256041_2256479_-\|hypothetical-protein	gnl\|CDD\|379297	pfam13620, CarboxypepD_reg, Carboxypeptidase regulatory-like domain.	0.00135235
CP020645.1\|AWP58407.1\|2247390_2248011_-\|XRE-family-transcriptional-regulator	gnl\|CDD\|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.01402e-16
CP020645.1\|AWP58415.1\|2253091_2253901_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	3.32527e-54

>CP020645.1|AWP58414.1|2252537_2252912_+|hypothetical-protein
MNATAAFLLAAALLPLVPAIAAKAGGRRYDNNDPRPWLAGQAGWRARANSAQANTFEALPFFFAAVLYALHTQAPAATLHVLMGAWLVARLVYVALYIGGRGNLRSLIWLAALLVNVAILLAGS
>CP020645.1|AWP58413.1|2251738_2252431_+|hypothetical-protein
MTEARAGLFARRRYLPALAVLYAALWLALAIEPHDRSDWLLENALVLGFGVALYATRRWFVFSRVSYTLIFLYLCLHAVGAHYTYSLVPYDAWWQRLTGHSLDQLLGWERNQFDRLVHFSYGLLLAYPIREIFLRVVEVRGFWGYLLPLDVALSTSALYELIEWGAAEFFGGELGVAYLGTQGDIWDAQKDMALAGLGALIAMLLTALFNRGARRDPARDWVDRMKPGHT
>CP020645.1|AWP58412.1|2251329_2251746_+|aminoacyl-tRNA-hydrolase
MLHVLGSLYLDERELDFDMIRAQGAGGQNVNKVSSAIHLRFDVRASSLPDSVKETVLALADRRISSDGVIVIKAQTHRSQEKNRADAVERLLALLREALRPVRPRRATRPTLGSQRRRVQRKVQHGETKRLRGRVRDD
>CP020645.1|AWP58411.1|2250586_2251219_-|7-carboxy-7-deazaguanine-synthase
MAYSVKELFKTLQGEGAQAGRAAVFCRFAGCNLWTGRESDRAGAACTFCDTDFVGTDGQGGGKFADAACLADAIAACWGDHPADRYVVFTGGEPLLQLDEALLQAVHAQGFTVAIETNGTLPPPPGIDWICVSPKGRAPVVVERGHELKLVFPQADARPEAFAHLAFEHFFLQPMDGPARAAHTAQAVQYCLDHPQWRLSLQTHKYIGIP
>CP020645.1|AWP58410.1|2250114_2250558_-|6-carboxytetrahydropterin-synthase-QueD
MISVTRRLEFDAGHRIPDHNSQCRNLHGHRYVLEVTLSGDVVQAPGASDNGMLMDFSEIKRIARTHIVDVWDHAFLVYEGDHAVRGFLDTLPDHKTVVLDRIPTAENLASIIFATLAPHYHGHYGADLRLTRVRLYETPNCWADCGS
>CP020645.1|AWP58409.1|2249001_2250093_+|ABC-transporter-substrate-binding-protein
MQRRRFLTAAAAGAGSAVLAAPAVAQEAPTIRWRMPSSFPRSLDTVWGAAEAITARVSELTDGKFAIRAFPAGELVPPLQVLDAVQNGTTECGHTAGFYYMGKEPALVFDTGVPFGLTPRQHSAWVLQGGGQALIDELYAGFNAIAIPCGNTGAQMGGWFRKQMRTPDDFKGLRIRTPGLLSMVYQKLGAIPQQIAGSDIYPALEKGSLDAVEFVGPYDDEKLGFAKVAQYYYGPGVMELGANLCLNVNRESWQSLPPRYQVALRAACAMAGEELLAKYDAHNIPALKRLVGQGAKLQSWSPEIMAAMQKATREVLEEYAGKNPRFAKVLESWRAFRADQLLWASVNDGAAERYLLATRENGL
>CP020645.1|AWP58408.1|2248146_2248947_+|aldolase
MESMMSSSYTVQDKDVLRARVDREIESRVSEPQWTRAQKMALACRMLAEQGHWHGGLAGQITARGDEPGTYWTLPFGVGADEARASELILIDEDLNPLDGKSLPNPANRFHIWIYRHRPNVQCIVHTHPPAVSALSMVGEPLVVAHMDATPFYNDCAYLPQWPGLPIGDNEGEVISAALGEKRAILLANHGLLTAGSSIEESAVMALWMEQAAMLQLRARAIGPVKAVPGELAQESHDFLVKPKIQSLTFAYFARRVLRAAPDCLD
>CP020645.1|AWP58407.1|2247390_2248011_-|XRE-family-transcriptional-regulator
MASCVLTHSPPPPMTAKSPPIPAPSPEQIGLRIRALRKRQKRTLAWLSAQCGLDKGFLSRLERGEKSASVGTLHTVAGALGSSLSALLGEADPQTEIQIVRAADRHRMTTAPGPGEHIYEAITLGSSHSGLSVMVVEVGTHGAHTEAHHGGDELIFVLDGRIRVHFGGHTVLLERDDSVRFPGYLPHSLSAEGRKLARALVVIASG
>CP020645.1|AWP58406.1|2246664_2247138_-|MarR-family-transcriptional-regulator
MKTATDNRLMAMTANLMVLSRAYRSAADKALADFGLSQATAWPVILTGRLGDGVRQGALAEALGVEGPSLVRVLDQLVAAGLIERREDPQDRRARTLHLTPAGQSLREQVENVLVQLRRQLFQGIADADLETCLRVFDSLKSALGRESAAAREDYRP
>CP020645.1|AWP58405.1|2244622_2246668_-|fusaric-acid-resistance-protein
MKLPTADEAVFSIKCYLGAMLALYLAYSIGLPRPFWAMTTAYVVAQPWSGAVRSKAVYRLGGTFFGSAMTIYTVPRLANYPVLMTLAMVLWVGLCLYIAVLDRTPRSYLFMLAGYTAAMIGFPSVTDPALVFDTALARVEEISLGIICATLVHSVVLPRGIGRAMMGRLDATVRDARSWIQDVLNQRGAAQHARDRRTLANDITQLRLLSTHVPFDTGNIRWTANALRAMQEHITALTPAVSAVEDRLQALQAQGRALPPPAARVLADISAWMDDSAHATREQAVQLRAALTRLAPAIDRQSGWHDALLASLVARLRELVDSYDACLVLRQDIHAGLGGAPTGRTRRLTRGAALHRDHGLALLSALAAALAISVCCLFWIGTAWTNGATAAMMAAIFSCFFAAQDNPVPGIMQFLTYTIYSIPLSALYLLGIMPALHSFEMLALAIFPVAFVTGVYIARPTTTGKAMAVFFGLSGTLALQDTHAADLVSFVDTIVAQIIGVAVAAIIAAVFRTVSAEWSARRIQAANWKELAALAGAGRAPARLDFTARMLDRIGLLQPRLALSKRRDDQLADDALQDLRVGKDIAELQRARRHLPMADPAIQPVLRTLAGLFRKRPGRLGGERPAELLQTIDRALYSVSNTPVAHAARERAVVALVGLRRAFFPEAAAYRPGRDVESPAS
>CP020645.1|AWP58415.1|2253091_2253901_-|IclR-family-transcriptional-regulator
MKNIPASAPRDTAQSLRRSIEILKALSAPMKRGFSLSELSRMTGLPHPTVLRLLRHLTGLGMVAWDPATKIYRLGTLTFELGLAAAEHCDIRGLCGDSLDRLQAETQDTCYLTMRSGFDAVCIDRREGASPIRVLTLDIGSRRPLGVGAAGLAILDCLPEEEAETVIQASESKLDRYNRMSTDIMRMLLQETRERGYAVCGNWVTLGVTAVAVPICIEDGRPIGSLSVSAVSHRMPADRWPGIARALRAEMHEIHRKLQGPSSRPGYGG
>CP020645.1|AWP58416.1|2253996_2254941_+|dihydrodipicolinate-synthase-family-protein
MAARFPGYVPAGVIPAALMPFNEDLSIDEKSLRAHIRDLASVRGISALCVNGVSQEIPGLTLDEQRRALDVMADEVGDQVPLMHGVYAHGPLDAARIARQAEAGGASCLLVFPPAVFARGAAMLPEMTLGHYKAIADATDLPLIVFQYETSTGMAHPLDTLVKLAEAVPSVMAIKDRSNNPIEHERNIRVLQSLARPVNVLTTHSAWLMPSLVLGCNGILSGSGSVHADLHVALWEAVQANDLAAARAINDQIYPMASCFYSAPTLDMHTRMKEALVMLGRLPSGRVRLPWVDLSDAERARVRAALVQAGRLPA
>CP020645.1|AWP58417.1|2254979_2255951_+|hypothetical-protein
MRVMQKGLMAALLLGSAFASAAAADSFPQRPVTIVVPFTPGGAVDIVARTVAAGLSEQWSQSVVVENKAGAGGAIGIQSVARAKPDGYTLLLGSVGPVTVNPSLGPVGYDVAKELAPVVLLAKTPAVLVTLPSAPVDDVAQFVKQAKAQPGGLNYGSAGTGNITHLVSEYFLSSAGLAANHIPYKGSAPAITDMLGGRLDFMFDVVPTAQPLIKSGKYKALAVTTIKRSDVLPDVPTLDELGYKGFDVSSWFSLMAPAGTPDAVIGQINAAVNEVLRSDASRERLAAIGAYSAGGTPEQLGEFVRSETARWKKLIDERGIRAN
>CP020645.1|AWP58418.1|2256041_2256479_-|hypothetical-protein
MNKRHERAWMAAALAAGSIALGGAVQAQGALPAVQQQGSVQFVTGGVGLDESEAMKAASKDYPLALTFAARGDGRAGLYLADVAVQILDRTGKPVLDAKADGPYLLAKLPAGTYRVKATSGGVEQTRQVSVRPGSTARAVFEWKD
>CP020645.1|AWP58419.1|2256537_2257419_-|hypothetical-protein
MGKTQEFLRLRRIIALSSLLASRKSAMCLAVLALHAIPGLPVLIAANRDEFHARPTAEATRWPGSPAIYAGRDLQAGGTWMGVSDQGRYAVVTNFRDPRNIQPDAPSRGALVEAFLRGAASAQEYLHDVHARGARYNGFNLIVGDAGGAWYCSNRDGAPRRLAAGVYALSNHLLDTPWPKLARTKAAFERIIAAAPQPDLAALYAALADPTPAADHELPATGLALERERLLSSPFIVSPDYGTRSACILALHDDGRGELHERRFRPDGAIAGQTDLDFPWRAAHAELHRASCV
>CP020645.1|AWP58420.1|2257500_2258190_+|type-1-glutamine-amidotransferase-domain-containing-protein
MKILMVLTSHDQLGDTGRKTGFWLEEFAAPYYVFVDAGARVTLASPAGGQPPLDPKSDEPDAQTEATRRFAADTQAQQALAHTAKLADMRAADFDALFYPGGHGPLWDLAESAHSTALIETFLAGGKPVAAVCHAPGVLRHARAADGAPLVAGRQVTGFSNTEEAVVQLTEVVPFLVEDELVGLGARYSKAEDWHAYVVNDGLLITGQNPASSERAARAMLTALDNGRG
>CP020645.1|AWP58421.1|2258204_2259809_-|FAD-dependent-oxidoreductase
MTAPTLAPIDPPARAQLLADLQGAPDWDVIVIGGGATGLGTAVDAAARGYRTLLVEAADFAKGTSSKATKLVHGGVRYLAQGNISLVREALHERGLLNRNAPHLVWPLGFVVPAYSLLDQPFYGVGLKMYDMLAGKLNLAPSRWLSRGETLRHAATVAERVNGRALRGGILYYDGQFDDARLAIALMRTLYDLGGVALNYARAVGLTRTDGRVDGVTVADALGELRVTLRAKCVVNATGVWVDAVRRMDDPAAQTMVAPSQGVHLTLPRDFLPGEDAILIPKTDDGRVLFVVPWNGHTIVGTTDTPRTDLPLDPQAGQNEIDFILATAARYLSRKPTRADVTSVWAGLRPLVKATGEASTKSLSREHTIVVSKGGLVTVTGGKWTTYRKMAQDVVDTAIEHKLLAAAPCRTSELPLHGAPADGQPNGAPHGTPDSYYGTDLATLRALPGADRMLVKASALTEAHVRYAARHELARTVEDVLARRNRALFLDAEAALLAAPEVARILAQELGHDEAWSRATLAEFEAVAAHYRLA
>CP020645.1|AWP58422.1|2259848_2260658_-|DeoR-family-transcriptional-regulator
MLFYDASMTLNPRQSALVELVRTQGSATIEALARHFDVTLQTVRRDVNLLSEAGMLSRFHGGVRIESSTIENIAYRKRQGLHAEGKRRIAEAVARAVPDGCSLLINIGTTTEAIARALLRHRGLRVITNNLHVADILSDNPDCEVIVAGGVVRSRDRGIVGEATLDFIRQFKVDIGLIGISGIEADGTLRDYDFREVRVARAIIEQSREVWLAADSSKFQRQAMVELVHVSRIHRFFTDAQPQESLAQVLQDAGVRCDVAAQSAGAAAA
>CP020645.1|AWP58423.1|2260762_2261845_+|ABC-transporter
MQLVLDGIQLRAGSQVHLYPLSLQPAPGAMTVLLGATLAGKTSVMRIMAGLDRPTEGKVLVDGADVTGVPVRQRNVAMVYQQFINYPSMRVADNIASPLRLRGAADIPARVRAMAERLHIEHLLDRYPSELSGGQQQRVALARALVKDAPLVLLDEPLVNLDYKLREALREELAGLFAQGRSTVVYATTEPAEALLLGGHTAVLDAGRLLQYGPTAEVFHRPNSIRVARAFSDPPMNLFPARRANGGFMLASGVMVPCALPPPETGDDALTAGLRAGVFRTEARGADVALPGVVELAEISGSDSFVHVRTPAGPVVAQLTGVHRYPLDSRLTLHFDPADSYAFGPDGALLAAPRRAGGER
>CP020645.1|AWP58424.1|2261844_2262933_+|ABC-transporter-ATP-binding-protein
MASIELDLAHAYGPDPRGEDDYALLPLRFTFEDGGAYALLGPSGCGKTTLLNCVSGLLRPSQGRVLFDGQDVTGRTPQQRNIAQVFQFPVVYDTMTVADNLAFPLRNRGVPQAHIRERVGRIAEMLELSAVLERRASGLTADAKQKISLGRGLVRSDVSAILFDEPLTVIDPHLKWELRRKLKEIHHEFKLTLIYVTHDQTEALTFAERVMVMSRGRAVQVGTPDDLFERPAHTFVGHFIGSPGMNFLPAEWRDGALRIGSQRLEGLTAGQAEALAQGGPVKLGVRPEYLRLVAPRTPGALPVRVARVQDVGTYALLGAEFESIALRARLPLDAALPGAGDTVWLAVLNRHTCFYRDEELIR

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Crispr_ID: CP020645_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_9

3152769-3152892

Orphan

Consensus_repeat	Method
GCCCCCACGCTGCGCCCGCTACGCGGGCTTGCTGCCCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_9

>merge|CP020645|9|3152769-3152892|CRISPRCasFinder
GCCCCCACGCTGCGCCCGCTACGCGGGCTTGCTGCCCCCCCAAGGGGGCCTTTTTGCCTTGGGACGGCCCGGCGGCAAAGTAGTGCCCCCACGCTGCGCCCGCTATGCGGGCTTGCTGCCCCCC

>CP020645|9|9|3152769-3152892|CRISPRCasFinder
GCCCCCACGCTGCGCCCGCTACGCGGGCTTGCTGCCCCCC	CAAGGGGGCCTTTTTGCCTTGGGACGGCCCGGCGGCAAAGTAGT
GCCCCCACGCTGCGCCCGCTATGCGGGCTTGCTGCCCCCC

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP59200.1\|3145962_3147174_-\|IscS-subfamily-cysteine-desulfurase	unknown	unknown	gnl\|CDD\|184450
CP020645.1\|AWP59203.1\|3148672_3150700_-\|UvrABC-system-protein-B	unknown	unknown	gnl\|CDD\|235395
CP020645.1\|AWP59206.1\|3152979_3154653_-\|autotransporter-outer-membrane-beta-barrel-domain-containing-protein	unknown	unknown	gnl\|CDD\|273608
CP020645.1\|AWP59199.1\|3145518_3145929_-\|iron-sulfur-cluster-scaffold-like-protein	unknown	unknown	gnl\|CDD\|183087
CP020645.1\|AWP59208.1\|3155942_3156584_-\|succinyl-CoA--3-ketoacid-CoA-transferase	unknown	unknown	gnl\|CDD\|188219
CP020645.1\|AWP59211.1\|3158306_3159470_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
CP020645.1\|AWP59209.1\|3156576_3157293_-\|3-oxoadipate-CoA-transferase	unknown	unknown	gnl\|CDD\|131482
CP020645.1\|AWP59207.1\|3154945_3155908_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270296
CP020645.1\|AWP59198.1\|3145193_3145517_-\|iron-sulfur-cluster-assembly-protein-IscA	unknown	unknown	gnl\|CDD\|213674
CP020645.1\|AWP59204.1\|3150777_3151980_+\|aromatic-amino-acid-aminotransferase	unknown	unknown	gnl\|CDD\|181731
CP020645.1\|AWP59197.1\|3144678_3145191_-\|co-chaperone-protein-HscB	unknown	unknown	gnl\|CDD\|235133
CP020645.1\|AWP59205.1\|3152030_3152759_+\|repressor-LexA	unknown	unknown	gnl\|CDD\|234688
CP020645.1\|AWP59214.1\|3161418_3161850_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224462
CP020645.1\|AWP59201.1\|3147191_3147704_-\|Fe-S-cluster-assembly-transcriptional-regulator-IscR	unknown	unknown	gnl\|CDD\|273927
CP020645.1\|AWP59215.1\|3161846_3162644_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|223955
CP020645.1\|AWP59213.1\|3160264_3161422_-\|thiolase	unknown	unknown	gnl\|CDD\|180434
CP020645.1\|AWP59196.1\|3142686_3144549_-\|molecular-chaperone-HscA	unknown	unknown	gnl\|CDD\|235360
CP020645.1\|AWP59212.1\|3159466_3160258_-\|3-oxoacyl-ACP-reductase	unknown	unknown	gnl\|CDD\|235546
CP020645.1\|AWP59210.1\|3157289_3158285_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173838
CP020645.1\|AWP59202.1\|3147919_3148411_-\|protein-tyrosine-phosphatase	unknown	unknown	gnl\|CDD\|319971

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP59200.1\|3145962_3147174_-\|IscS-subfamily-cysteine-desulfurase	gnl\|CDD\|184450	PRK14012, PRK14012, IscS subfamily cysteine desulfurase.	0
CP020645.1\|AWP59203.1\|3148672_3150700_-\|UvrABC-system-protein-B	gnl\|CDD\|235395	PRK05298, PRK05298, excinuclease ABC subunit UvrB.	0
CP020645.1\|AWP59206.1\|3152979_3154653_-\|autotransporter-outer-membrane-beta-barrel-domain-containing-protein	gnl\|CDD\|273608	TIGR01414, Contains:_AIDA-I_translocator, outer membrane autotransporter barrel domain. A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	1.01777e-85
CP020645.1\|AWP59199.1\|3145518_3145929_-\|iron-sulfur-cluster-scaffold-like-protein	gnl\|CDD\|183087	PRK11325, PRK11325, scaffold protein; Provisional.	5.84746e-99
CP020645.1\|AWP59208.1\|3155942_3156584_-\|succinyl-CoA--3-ketoacid-CoA-transferase	gnl\|CDD\|188219	TIGR02428, 3-oxoadipate_CoA-transferase_subunit_B, 3-oxoacid CoA-transferase, B subunit. Various members of this family are characterized as the B subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The A subunit represents a different clade in pfam01144.	2.62006e-117
CP020645.1\|AWP59211.1\|3158306_3159470_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	2.26439e-78
CP020645.1\|AWP59209.1\|3156576_3157293_-\|3-oxoadipate-CoA-transferase	gnl\|CDD\|131482	TIGR02429, 3-oxoadipate_CoA-transferase_subunit_A, 3-oxoacid CoA-transferase, A subunit. Various members of this family are characterized as the A subunits of succinyl-CoA:3-ketoacid-CoA transferase (EC 2.8.3.5), beta-ketoadipate:succinyl-CoA transferase (EC 2.8.3.6), acetyl-CoA:acetoacetate CoA transferase (EC 2.8.3.8), and butyrate-acetoacetate CoA-transferase (EC 2.8.3.9). This represents a very distinct clade with strong sequence conservation within the larger family defined by pfam01144. The B subunit represents a different clade in pfam01144, described by TIGR02428. The two are found in general as tandem genes and occasionally as a fusion.	9.71433e-141
CP020645.1\|AWP59207.1\|3154945_3155908_-\|hypothetical-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	2.43068e-138
CP020645.1\|AWP59198.1\|3145193_3145517_-\|iron-sulfur-cluster-assembly-protein-IscA	gnl\|CDD\|213674	TIGR02011, Protein_yfhF., iron-sulfur cluster assembly protein IscA. This model represents the IscA component of the ISC system for iron-sulfur cluster assembly. The ISC system consists of IscRASU, HscAB and an Isc-specific ferredoxin. IscA previously was believed to act as a scaffold and now is seen as an iron donor protein. This clade is limited to the proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other].	4.04388e-54
CP020645.1\|AWP59204.1\|3150777_3151980_+\|aromatic-amino-acid-aminotransferase	gnl\|CDD\|181731	PRK09257, PRK09257, aromatic amino acid transaminase.	0
CP020645.1\|AWP59197.1\|3144678_3145191_-\|co-chaperone-protein-HscB	gnl\|CDD\|235133	PRK03578, hscB, Fe-S protein assembly co-chaperone HscB.	9.27785e-79
CP020645.1\|AWP59205.1\|3152030_3152759_+\|repressor-LexA	gnl\|CDD\|234688	PRK00215, PRK00215, transcriptional repressor LexA.	3.8031e-107
CP020645.1\|AWP59214.1\|3161418_3161850_-\|hypothetical-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	3.2445e-21
CP020645.1\|AWP59201.1\|3147191_3147704_-\|Fe-S-cluster-assembly-transcriptional-regulator-IscR	gnl\|CDD\|273927	TIGR02010, Putative_HTH-type_transcriptional_regulator, iron-sulfur cluster assembly transcription factor IscR. This model describes IscR, an iron-sulfur binding transcription factor of the ISC iron-sulfur cluster assembly system. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Regulatory functions, DNA interactions].	1.00126e-77
CP020645.1\|AWP59215.1\|3161846_3162644_-\|enoyl-CoA-hydratase	gnl\|CDD\|223955	COG1024, CaiD, Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism].	8.52033e-63
CP020645.1\|AWP59213.1\|3160264_3161422_-\|thiolase	gnl\|CDD\|180434	PRK06158, PRK06158, thiolase; Provisional.	0
CP020645.1\|AWP59196.1\|3142686_3144549_-\|molecular-chaperone-HscA	gnl\|CDD\|235360	PRK05183, hscA, chaperone protein HscA; Provisional.	0
CP020645.1\|AWP59212.1\|3159466_3160258_-\|3-oxoacyl-ACP-reductase	gnl\|CDD\|235546	PRK05653, fabG, 3-oxoacyl-ACP reductase FabG.	2.77483e-80
CP020645.1\|AWP59210.1\|3157289_3158285_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	1.3519e-19
CP020645.1\|AWP59202.1\|3147919_3148411_-\|protein-tyrosine-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	1.52289e-75

>CP020645.1|AWP59205.1|3152030_3152759_+|repressor-LexA
MRLAFFPWVLQNGAVYPYSPQKRVITMATKLTERQQEILDLIRQTVARTGFPPTRAEIAQALGFRSPNAAEDHLKALARKGAIELTAGASRGIRLKVPDSAAPSAQLTHPLLAQLVLPLVGRVAAGSPILASEHVEREVGVDPGLFTQTPDYLLKVRGMSMRDAGILEGDLLAVKRAAEARNGQIVVARLGDEVTVKRLQRQNGRIELLPENPDFSPIVVANTDDFALEGIAVGLIRTQPLH
>CP020645.1|AWP59204.1|3150777_3151980_+|aromatic-amino-acid-aminotransferase
MSTLFASVELAPRDPILGLNEQYNADTRPGKVNLGVGVYYDDEGRIPLLQAVRKAEVARIEAAAARGYLPIEGIAGYNKGAQALLLGADSPLAAEGRVLTAQALGGTGALKIGADFLRQLLPQSKVLISDPSWENHRALFERAGFPVETYAYYDAATHGLNFEAMLAALQAAPEQTIVVLHACCHNPTGVDPTPQQWEQIAAVVKARNLVPFLDIAYQGFGEGLEQDAAVVRMFAALDLTMFISSSFSKSFSLYGERVGALTVVAGSKDEAARVLSQLKRVIRTNYSNPPTHGGTVVSTVLNTPELFALWENELAGMRDRIRLMRKELVEKIKAQGVAQDFSFVLAQRGMFSYSGLTAAQVDRLREEHGIYAVSSGRICVAALNSRNIDAVAAGIAAVLK
>CP020645.1|AWP59203.1|3148672_3150700_-|UvrABC-system-protein-B
MTAPGFVEFPDSPFHLYQPYPPAGDQPGAIDALTEGVSDGLMFQTLLGVTGSGKTYTMANMIARLGRPALVLAPNKTLAAQLYAEMREFFPRNAVEYFVSYYDYYQPEAYVPTRDLFIEKDSSINEHIEQMRLSATKSLLERRDTVIVGTVSCIYGIGNPGDYHAMVLILRTGDRISRREVLARLVAMQYTRNDADFTRGVFRVRGETIDIFPAESPELALRLTLFDDEIESLELFDPLTGRVRQKLPRFTVYPGSHYVTPRETVLRAIETIKEELRERLAQLIADGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHLSGAAPGEPPPTLIDYLPADALMFIDESHVTIGQLGGMYRGDRSRKETLVQYGFRLPSALDNRPLRLEEFEARMRQCVFVSATPAAYEQEHADNVVEQVVRPTGLVDPIVEVRPAHTQVDDLLGEIHKRAALQERVLVTTLTKRMAEDLTDFLSEHGVRVRYLHSDIDTVERVEIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGRAILYADRITDSMRRAIDETERRRAKQIQHNTDHGITARGVSKAVRELIDGVVAPAGHDALESAVPAEVLTDEKAMAREIRRLEKLMMDHARNLEFEQAAAARDALNALKSRLLLDGVG
>CP020645.1|AWP59202.1|3147919_3148411_-|protein-tyrosine-phosphatase
MMTKVLFVCMGNICRSPSAEGVFRHLVNDAGMGDVVRVDSAGTHAFHIGEAPDARAQAAARKRGYDLTHCEARQVTADDFREFDLILAMDWDNLAALQQQCPKAYQHKLMLLMRFANEFEEATVPDPYYGGPEGFGKVLDYLEDACQGVLELVRKRATQYQAA
>CP020645.1|AWP59201.1|3147191_3147704_-|Fe-S-cluster-assembly-transcriptional-regulator-IscR
MRLTTKGRFAVTAMIDLAMRQHSGPVTLAAISQRQNISLSYLEQLFGKLRRHELVDSVRGPGGGYSLARLARNVTVADIIFAVDEPLDATSCGGKRDCTSGNDGKPGKCMTHELWTTLNRKMVDYLDSVSLQDLVDQQRVRQLQEAANQAQGCSAVRVNRSTPVAANATA
>CP020645.1|AWP59200.1|3145962_3147174_-|IscS-subfamily-cysteine-desulfurase
MSNRPIYLDYSATTPVDPRVVEKMIPWLYESFGNPASRSHAFGWEAEDAVEKAREEVAKLVNADPREIVWTSGATESDNLAIKGAANFYAERGKHIITVKTEHKAVLDTCRELERQGFEVTYLDVQDDGLLSLDAFKAALRPDTILVSVMMVNNEIGVIQDIAALGEICREKGIIFHVDAAQATGKVEIDLQKLKVDLMSFSAHKTYGPKGIGALYVRRKPRVRIEAQMHGGGHERGFRSGTLATHQIVGMGEAFRLAREEMGTENERVRMLRDRLLAGLTQIEEVYVNGSMEHRVPHNLNISFNYVEGESLIMAIKELAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTLGRFTTEQEIDFTIELIKSRVGKLRDMSPLWEMAQEGIDLNSVQWAAH
>CP020645.1|AWP59199.1|3145518_3145929_-|iron-sulfur-cluster-scaffold-like-protein
MAYSSKVLDHYENPRNVGSFDKGDDSVGTGMVGAPACGDVMKLQIKVNEAGVIEDARFKTYGCGSAIASSSLVTEWVKGKTLDEAMNIRNTQIAEELALPPVKIHCSILAEDAIKAAVQDYKTKHGAETPEAVAAN
>CP020645.1|AWP59198.1|3145193_3145517_-|iron-sulfur-cluster-assembly-protein-IscA
MAVTLTQSAANHVGRYLQKRGKGIGLRLGVRTTGCSGMAYKLEYVDEQAADDVVFDSFGVKVFIDPKSLAYLDGTELDYAREGLNEGFRFSNPNEKATCGCGESFTV
>CP020645.1|AWP59197.1|3144678_3145191_-|co-chaperone-protein-HscB
MAADDHFSLFGLPARFALDPVQLEQAWRAVAARVHPDRYATASAAERRVAMQWAARANEAYRQLRDPMLRARYLCEQAGVDLQTESNTAMDPAFLMQQMEWREMLDDARRDPAAFAALRAELEQARLRMQQTLSELIDERGDYQQAGTKVREWMFVEKLAQELSAAQPMQ
>CP020645.1|AWP59196.1|3142686_3144549_-|molecular-chaperone-HscA
MALLQISEPGDSPAPHQRKLAVGIDLGTTNSLVAAVRSSVPEVLADAQGQVLLPSAVRYLDGGAVRIGREALLEQARDPLNTIVSVKRFMGRSAADALASGAPYEFVDAPGMVRLRTVQGDLSPVEVSAQILAVLRQRAEDVLGDDLVGAVITVPAYFDDAQRQATRDAARLAGLNVLRLLNEPTAAAIAYGLDQAAEGIYAVYDLGGGTFDISILRLTQGVFEVIATGGDTALGGDDFDSAIVAHACAGEDVAALPVADRRALLVAARAAREALTDQAQAPFEVTLRDGRAIQATLTRAQFEQLAEPLVGRTLDSARRALRDAGLAVGDVRGVVMVGGATRMPVVRQQVGALFGTEPLTNLDPDQVVALGAALQANLLAGNRAPGEDWLLLDVIPLSLGLETMGGLVERIIPRNSTIPVARAQEFTTFKDGQTAMSVHVVQGERDLVSDCRSLARFELRGIPPMVAGAARIRVTFQVDADGLLSVTAREQSTGVEAAVAVKPSYGLSDDEIARMLADSVTQADSDARARMLREQQVEARQLVESVGAALAADGDLLDPAERATVDQRLQAAAQAQSLDDVEAVRAAVQALSDATEEFAARRMDRSIRAALAGRKLDELA
>CP020645.1|AWP59206.1|3152979_3154653_-|autotransporter-outer-membrane-beta-barrel-domain-containing-protein
MPSDSSISCKSRSRSMALARRRLAWPGVCGALSLAAWLAPAQDAMAAPGPKGVPAVSVPMLDGRPVDDENGWTTIDLDGTAIDDAIDDTWTEIDLSDDALHGGTDGDTSIGLPPPGLDGTPIGEEWIEIEIPPPDLDGESLDDDHTHIDTPQPELDGAPADGEDGGLPSPPAEAPQAGPDASKPQPEGPPEPDGNPQPDVEPGPEVEPGPEVEPGPQEQPRPQPDARPQDEPHAQPLPPAGSPGDGIYMPRSGILTAPVLAVLGTASAPQGIWQAEMNALSKRMGELRLTPAAGGVWARSFAQRQRLDNQVVDRFTQTVGGIEIGADTALPAAEGRWHVGAVAGYSRARRKLAYSARGNSDSLHVGAYATYIGDGGFYLDGIVRVNRYEHDFKADGQRGARVTGKYRANGIGLSLETGRRFTWAGDWFVEPQVEVALFRSGKADYTASNGVRVDVASTKSLLGRLGLQVGRKLDLGNGKLVQPYAKLSWLQEFDGVGKVRTNDIGHDVKLRGGRAELDLGVAAALGKHSSLFASYEYSKGSRLTIPWSFHVGYRYAW
>CP020645.1|AWP59207.1|3154945_3155908_-|hypothetical-protein
MKTKIKIVTLALCAFSSAVFASSFPSKPINLIVPYPPGGAVDPIARLYAEKISQSWGVPVIVLNRPGAGTTIGLNQAARAEPDGYTVVLGTASITSNAPLYRSLPYDTLKDFTYLSMAGMIPLAITANPRTAVDSMDELVGQLKKKPGSLTYSSSGNGTIIHLGGELFKSLAGVDMVHVPYKGSGPSVMAGVAGEVDLTFDSVFLMDPQVKAGKLKYIAVASEKRLKSLPEVPAIGEKYPGYFVTSWVGFMGPAGISADITAAWAKEIARVAALPDVSDKLATLGVESVSSTPQQFSAFVESEIRKWEKVVQDAHIPPVQ
>CP020645.1|AWP59208.1|3155942_3156584_-|succinyl-CoA--3-ketoacid-CoA-transferase
MSKGWSNDEIAARIAVDLPEHAIVNLGIGLPILVANHIPEGKTIFFHSENGIIGLGPVPAPGQEDPDIVNAAKKHATLIAGASIVHHADSFSLIRGGRLDYSILGGLQVSSGGDIANWKVPGQKGGGGVGGAMDLAVGARNVLVMMRHQDKTGASKLVKSCTFPLTAVSAVTRVYTELGIFECAGDAFIVRESAPGVGKDELLRKTEAALTFP
>CP020645.1|AWP59209.1|3156576_3157293_-|3-oxoadipate-CoA-transferase
MTAGTSTHFNQVNGVGMLNKTCESADEAVSVVESGATILISGFGDIGLPFELLHALARTSVKDLTIVSNNAGTGELGLSRLFRNRQVARLIASFPSQPDSHHYFAAYQEGLVDLELVPQGTLAERIRAAGAGLAGFFTPTGYGTELAQGKECRMFKGKGYVFEEALPGDFAFIKAHVADAYGNLRYRRASRTFNPIMAMAARTTIAEAKQMVPVGSIDPDDVHTPGVFVDRIVEVRDE
>CP020645.1|AWP59210.1|3157289_3158285_-|acyl-CoA-dehydrogenase
MYSDAFEDLLKGRCEPAVVRAIEAGGDVQALWDAIVQSGFLDLMAPEQAGGAAADLADALPLFTALGAYAVPLPVGQAIALRTLLPAGMEVPGGLPSFAPALRTGPDGALRAPRVPYGMLAGPVLGELDGALCLLDARAAQRRDCGLHGEPTADLSWDAGVRQDAVRRLDDAGGAPGRLAAWGAALHAALLTGAMTRCFEMSLQYGNDRTQFGRSIGKFQAVQHQLAVMAEHVAAARIATAAAFRAGLTQPALLPAAIAKARASEAAALAANTAHAVHGAIGVTEEYDLQLYTRRLHGWRLAHGSEAYWHQVVGAALMGSGEGAVQFVRAL
>CP020645.1|AWP59211.1|3158306_3159470_-|acyl-CoA-dehydrogenase
MIVSALIDRFELAELPARAQAFRQDVQAFLKAELPPLPADRRARSWMGFDAGFSRKLAARGWVGVTLPRAYGGAEMDAFSRFVLIEELLCAGAPVSAHWIADRQSGPQIRKFGSEAQRSFYLPRICRGEAFFCIGMSEPNSGSDLASVGTRATRRADGGWTLSGRKIWTTNAQHCHYMIALVRTSGTPQDRNQGLSQFIVDLSLPGVTVRPIADLAGDAHFSEVFFDDVQLSDEALIGQEGSGWEQVTAELAFERSGPERIYSSMVLLDGWIQWLRGRGDVSQTAAVGRYATHLAALRNLSLSVTARLAAGESPVVEAALVKELGTTFEQEIPAAIEAALGSDPGADIDAELLRTCAYVNQVCPTYSLRGGTREILRGMIARGLGLR
>CP020645.1|AWP59212.1|3159466_3160258_-|3-oxoacyl-ACP-reductase
MKETAMQDKLLTLENRQVIVTGAGQGIGRALASAIAELGGRVVAVDLNADALAALREALGHERCVTVAGNVADPSLAQQAVDAGVAAFGGVNGLVNNAGVTRTAMIDKMSISDWQQVIDVHLSGSFYFLQALGRHLLGRAKAGGDGAGAIVNISSDAGRRGTIGQINYGAAKAGVLGLTMCAAREWARYGIRTNTVGFGVVETPMTETIRGEKFRDTYLSQIPLGRWGEADEVVRPVCFLLSDAASYVTGQHLSVNGGYTIGL
>CP020645.1|AWP59213.1|3160264_3161422_-|thiolase
MIQERFPRGKTAIVASATYGIGESPGLSSLDLAVRASVQALGSVGLTPADVDGLFIGLPDDFVSGLSFTEYLGISPRLTDNNRTGGSSFLTHAIHAALALEAGLCDVALIAYGSNQRSGAGKLVSSMRPSPYEAAYKLARPVGAYALAASRYAAQYGLKKEQLGAVALAARQWAQKNPEAYLRAPLTMDEYLASRLVCDPFSVRDCCLVTDGAAAVVMVRADRARDLAARPAYLLGGAAAAWHKDITNMPDLTVTAASLSGPRAMAQAGVTPADIDVLELYDAFTLNTILFLEDLGFCAKGEGGAFVEDGRIAPGGSLPVNTNGGGLSCVHPGMYGLFTMVEAAQQLAGAAGDRQVAQARLALAHGNGGELSSQATLILGTEETI
>CP020645.1|AWP59214.1|3161418_3161850_-|hypothetical-protein
MTEHPQAASALLPQQEYFAHLADGRFMIQRSRSSGEYVFYPRVAAPRTGAQDLEWVAASGRGTVYATTVMRVRPPAAPYNVCLVELEEGPRMMSRVEGIGPEDVQVGMAVRARIVRDDAGEPLVVFEPAGPSDAGIGQGRAAQ
>CP020645.1|AWP59215.1|3161846_3162644_-|enoyl-CoA-hydratase
MSVLEISRVGACAVLTLNRPNARNALDMALREALATALPGIRDDATVRAVVLTGAGGHFCAGGDIRAIAAGQGNADVFEGRNRIVSMQRWFDELVDLEKPVIAAVDGVAFGAGLSLALAADFVLASPRATFCAVFARLGYVPDLGGMYLLPRTVGLARAKALAFSARVVGAPEALEMGIAHQLVDDRPVLDAALELAGRFEQAPAGALGIVKSVMNHAFESDRRTVYMQEALAQALCRESAFHQEAARRFLDKQAPLYQWPQEQQ

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Crispr_ID: CP020645_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_10

3690465-3690573

Orphan

Consensus_repeat	Method
CCTGCCGACTTCCGGGGTGCCTGTCCC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of CP020645_10

>merge|CP020645|10|3690465-3690573|CRISPRCasFinder
CCTGCCGACTTCCGGGGTGCCTGTCCCCACGCGGACAGGCACCTGCTGACTTCCGGGGTGCCTGTCCCCACGCGGACAGGCGCCTGCCGACTTCCAGGGTGCCTGTCCC

>CP020645|10|10|3690465-3690573|CRISPRCasFinder
CCTGCCGACTTCCGGGGTGCCTGTCCC	CACGCGGACAGGCACCTGCTGACTTCCGGGGTGCCTGTCCCCACGCGGACAGGCG
CCTGCCGACTTCCAGGGTGCCTGTCCC

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP59656.1\|3682161_3683250_-\|phenylacetic-acid-degradation-protein	unknown	unknown	gnl\|CDD\|131215
CP020645.1\|AWP59662.1\|3686955_3687642_-\|NAD(P)H-hydrate-epimerase	unknown	unknown	gnl\|CDD\|223140
CP020645.1\|AWP59669.1\|3693579_3694452_+\|multidrug-DMT-transporter-permease	unknown	unknown	gnl\|CDD\|274527
CP020645.1\|AWP59661.1\|3686054_3686984_+\|phenylacetic-acid-degradation-operon-negative-regulatory-protein	unknown	unknown	gnl\|CDD\|274064
CP020645.1\|AWP59673.1\|3697807_3698716_-\|sulfate-adenylyltransferase-small-subunit	unknown	unknown	gnl\|CDD\|235375
CP020645.1\|AWP59657.1\|3683261_3683768_-\|phenylacetate-CoA-oxygenase-subunit-PaaJ	unknown	unknown	gnl\|CDD\|131214
CP020645.1\|AWP59663.1\|3687675_3688221_-\|oligoribonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|235429
CP020645.1\|AWP59666.1\|3690606_3691761_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|381320
CP020645.1\|AWP59675.1\|3699514_3700579_-\|sulfate/thiosulfate-import-ATP-binding-protein-CysA	unknown	unknown	gnl\|CDD\|213263
CP020645.1\|AWP59658.1\|3683764_3684529_-\|phenylacetate-CoA-oxygenase-subunit-PaaI	unknown	unknown	gnl\|CDD\|368300
CP020645.1\|AWP59670.1\|3694459_3694840_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|237030
CP020645.1\|AWP59667.1\|3691757_3692483_-\|coenzyme-A-pyrophosphatase	unknown	unknown	gnl\|CDD\|239518
CP020645.1\|AWP59664.1\|3688265_3689531_+\|peptidase-M48	unknown	unknown	gnl\|CDD\|320702
CP020645.1\|AWP59672.1\|3696456_3697755_-\|sulfate-adenylyltransferase	unknown	unknown	gnl\|CDD\|180120
CP020645.1\|AWP59659.1\|3684544_3684829_-\|phenylacetate-CoA-oxygenase-subunit-PaaB	unknown	unknown	gnl\|CDD\|237504
CP020645.1\|AWP59665.1\|3689527_3690430_+\|ribosome-biogenesis-GTPase	unknown	unknown	gnl\|CDD\|234631
CP020645.1\|AWP59668.1\|3692891_3693272_-\|50S-ribosomal-protein-L19	unknown	unknown	gnl\|CDD\|235418
CP020645.1\|AWP59674.1\|3698765_3699518_-\|phosphoadenosine-phosphosulfate-reductase	unknown	unknown	gnl\|CDD\|234997
CP020645.1\|AWP59660.1\|3684893_3685883_-\|phenylacetate-CoA-oxygenase-subunit-PaaA	unknown	unknown	gnl\|CDD\|184320
CP020645.1\|AWP59671.1\|3694993_3696268_-\|radical-SAM-protein	unknown	unknown	gnl\|CDD\|275263

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP59656.1\|3682161_3683250_-\|phenylacetic-acid-degradation-protein	gnl\|CDD\|131215	TIGR02160, 12-phenylacetyl-CoA_epoxidase_subunit_E, phenylacetate-CoA oxygenase/reductase, PaaK subunit. Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other].	2.55159e-158
CP020645.1\|AWP59662.1\|3686955_3687642_-\|NAD(P)H-hydrate-epimerase	gnl\|CDD\|223140	COG0062, COG0062, Uncharacterized conserved protein [Function unknown].	5.71851e-45
CP020645.1\|AWP59669.1\|3693579_3694452_+\|multidrug-DMT-transporter-permease	gnl\|CDD\|274527	TIGR03340, phn_DUF6, phosphonate utilization associated putative membrane protein. This family of hydrophobic proteins has some homology to families of integral membrane proteins such as (pfam00892) and may be a permease. It occurs in the vicinity of various types of operons for the catabolism of phosphonates in Vibrio, Pseudomonas, Polaromonas and Thiomicrospira.	3.97287e-26
CP020645.1\|AWP59661.1\|3686054_3686984_+\|phenylacetic-acid-degradation-operon-negative-regulatory-protein	gnl\|CDD\|274064	TIGR02277, Transcriptional_repressor_PaaX, phenylacetic acid degradation operon negative regulatory protein PaaX. This transcriptional regulator is always found in association with operons believed to be involved in the degradation of phenylacetic acid. The gene product has been shown to bind to the promoter sites and repress their transcription. [Regulatory functions, DNA interactions].	1.27082e-140
CP020645.1\|AWP59673.1\|3697807_3698716_-\|sulfate-adenylyltransferase-small-subunit	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
CP020645.1\|AWP59657.1\|3683261_3683768_-\|phenylacetate-CoA-oxygenase-subunit-PaaJ	gnl\|CDD\|131214	TIGR02159, Putative_12-phenylacetyl-CoA_epoxidase_subunit_D, phenylacetate-CoA oxygenase, PaaJ subunit. Phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA (PA-CoA) as the second catabolic step in phenylacetic acid (PA) degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA. [Energy metabolism, Other].	1.57091e-58
CP020645.1\|AWP59663.1\|3687675_3688221_-\|oligoribonuclease	gnl\|CDD\|235429	PRK05359, PRK05359, oligoribonuclease; Provisional.	3.19199e-129
CP020645.1\|AWP59666.1\|3690606_3691761_-\|oxidoreductase	gnl\|CDD\|381320	cd19094, AKR_Tas-like, Escherichia coli Tas protein and similar proteins. Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.	0
CP020645.1\|AWP59675.1\|3699514_3700579_-\|sulfate/thiosulfate-import-ATP-binding-protein-CysA	gnl\|CDD\|213263	cd03296, ABC_CysA_sulfate_importer, ATP-binding cassette domain of the sulfate transporter. Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-binding protein (cysP). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	5.12136e-166
CP020645.1\|AWP59658.1\|3683764_3684529_-\|phenylacetate-CoA-oxygenase-subunit-PaaI	gnl\|CDD\|368300	pfam05138, PaaA_PaaC, Phenylacetic acid catabolic protein. This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid. These proteins may form part of a dioxygenase complex.	9.42173e-121
CP020645.1\|AWP59670.1\|3694459_3694840_-\|hypothetical-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00514117
CP020645.1\|AWP59667.1\|3691757_3692483_-\|coenzyme-A-pyrophosphatase	gnl\|CDD\|239518	cd03426, CoAse, Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative stress. CoAse has a conserved Nudix fold and requires a single divalent cation for catalysis. In addition to a signature Nudix motif G[X5]E[X7]REUXEEXGU, where U is Ile, Leu, or Val, CoAse contains an additional motif upstream called the NuCoA motif (LLTXT(SA)X3RX3GX3FPGG) which is postulated to be involved in CoA recognition. CoA plays a central role in lipid metabolism. It is involved in the initial steps of fatty acid sythesis in the cytosol, in the oxidation of fatty acids and the citric acid cycle in the mitochondria, and in the oxidation of long-chain fatty acids in peroxisomes. CoA has the important role of activating fatty acids for further modification into key biological signalling molecules.	5.50907e-72
CP020645.1\|AWP59664.1\|3688265_3689531_+\|peptidase-M48	gnl\|CDD\|320702	cd07343, M48A_Zmpste24p_like, Peptidase M48 subfamily A, a type 1 CaaX endopeptidase. This family contains peptidase family M48 subfamily A which includes a number of well-characterized genes such as those found in humans (ZMPSTE24, also known as farnesylated protein-converting enzyme 1 or FACE-1 or Hs Ste24), Taenia solium metacestode (TsSte24p), Arabidopsis (AtSte24) and yeast (Ste24p). Ste24p contains the zinc metalloprotease motif (HEXXH), likely exposed on the cytoplasmic side. It is thought to be intimately associated with the endoplasmic reticulum (ER), regardless of whether its genes possess the conventional signal motif (KKXX) in the C-terminal. Proteins in this family proteolytically remove the C-terminal three residues of farnesylated proteins. Ste24p is involved in the post-translational processing of prelamin A to mature lamin A, a major component of the nuclear envelope. ZmpSte24 deficiency causes an accumulation of prelamin A leading to lipodystrophy and other disease phenotypes, while mutations in this gene or in that encoding its substrate, prelamin A, result in a series of human inherited diseases known as laminopathies, the most severe of which are Hutchinson Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) which arise due to unsuccessful maturation of prelamin A. Two forms of mandibuloacral dysplasia, a condition that causes a variety of abnormalities involving bone development, skin pigmentation, and fat distribution, are caused by mutations in two different genes; mutations in the LMNA gene, which normally provides instructions for making lamin A and lamin C, cause mandibuloacral dysplasia with A-type lipodystrophy (MAD-A), and mutations in the ZMPSTE24 gene cause mandibuloacral dysplasia with B-type lipodystrophy (MAD-B). Within cells, these genes are involved in maintaining the structure of the nucleus and may play a role in many cellular processes. Certain HIV protease inhibitors have been shown to inhibit the enzymatic activity of ZMPSTE24, but not enzymes involved in prelamin A processing.	6.4862e-173
CP020645.1\|AWP59672.1\|3696456_3697755_-\|sulfate-adenylyltransferase	gnl\|CDD\|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
CP020645.1\|AWP59659.1\|3684544_3684829_-\|phenylacetate-CoA-oxygenase-subunit-PaaB	gnl\|CDD\|237504	PRK13781, paaB, phenylacetate-CoA oxygenase subunit PaaB; Provisional.	1.02662e-65
CP020645.1\|AWP59665.1\|3689527_3690430_+\|ribosome-biogenesis-GTPase	gnl\|CDD\|234631	PRK00098, PRK00098, GTPase RsgA; Reviewed.	3.59098e-160
CP020645.1\|AWP59668.1\|3692891_3693272_-\|50S-ribosomal-protein-L19	gnl\|CDD\|235418	PRK05338, rplS, 50S ribosomal protein L19; Provisional.	1.34063e-62
CP020645.1\|AWP59674.1\|3698765_3699518_-\|phosphoadenosine-phosphosulfate-reductase	gnl\|CDD\|234997	PRK02090, PRK02090, phosphoadenylyl-sulfate reductase.	1.8821e-107
CP020645.1\|AWP59660.1\|3684893_3685883_-\|phenylacetate-CoA-oxygenase-subunit-PaaA	gnl\|CDD\|184320	PRK13778, paaA, phenylacetate-CoA oxygenase subunit PaaA; Provisional.	0
CP020645.1\|AWP59671.1\|3694993_3696268_-\|radical-SAM-protein	gnl\|CDD\|275263	TIGR04470, hypothetical_protein_ALIPUT_00462, radical SAM mobile pair protein B. Members of this family are the downstream member (B) of a pair of tandem-encoded radical SAM enzymes. Most of these radical SAM gene pairs have an additional upstream regulatory gene in the MarR family. Examples of high sequence identity (over 96 percent) from cassettes in several Treponema species of the oral cavity to those in multiple Firmicutes in the gut microbiome suggest recent lateral gene transfer, as might be expected for antibiotic resistance genes. The function is unknown.	4.20987e-24

>CP020645.1|AWP59665.1|3689527_3690430_+|ribosome-biogenesis-GTPase
MSSNQAEGLIIAAHGRHYTVELADGSLRQCFPRGKKNGPAVGDRVRITPQGRDEGAIEAVLPRRNLLFRSDEMRVKQFAANVDQLLIVVAVEPTFADDLTGRSLAGAWSADIEPVIVLNKIDLPNGLDAARARLEPLRRLGVPVIELSAQDHAMVHERLAPRLAGRTSLLLGQSGMGKSTLLNTLVPHAQAATREYSAALDMGRHTTTSTRLYHLPEPGGDLIDSPGFQAFGLQHLNGEQILRGFPEFAPHIEHCRFYNCTHRHEPGCGVLAALQAGQIDAGRYALYLRILDENAAARPY
>CP020645.1|AWP59664.1|3688265_3689531_+|peptidase-M48
MTAPVPLFTLFFVVLLLADIGVRLWLATRQIRHVAAHRQSVPPEFAPRIGLHSHQRAADYTVARVRLGMLERVYDAAILVALTLLGGLQFIDLWLGQLTQHDFLRQLLLLACVPLLLGLLGLPFTLWRQFRLEGRFGFNRMTPALFFSDAVKGVLVALVLGLPLAAAVLWLMAGAGAYWWLWAWGLWLGYNLLLLLIYPTFIAPLFNKFTPLNDPELAGRIRQLAQRCGFALNGLFVMDGSRRSAHGNAYFTGFGKSRRIVFFDTLLARLNGDEIEAVLAHELGHFARRHIIKRLALSFAGALAFFAALGWLARQPWFYEGLGVLPNLGGRNDAMALVLFFLVVPVFTFMLTPLASWYSRRDEFEADRYAAAQSSPDRLVSALVKLYDDNAATLTPDPVHSAFYDSHPPAAVRIRHLMAGA
>CP020645.1|AWP59663.1|3687675_3688221_-|oligoribonuclease
MAANENRLVWLDMEMTGLDPEKERIIEVAVVVTEADLTVVAEGPVLVVHQPDSLLDAMDNWNKSTHGKSGLIEKVKASTLGEAQAEQILLEFLAEHVPAGKSPLCGNTISQDRRFMYAYMPNLERFFHYRNLDVSTLKELARRWAPAVYKGFDKKSRHEALADIYESIDELKYYREHLLKV
>CP020645.1|AWP59662.1|3686955_3687642_-|NAD(P)H-hydrate-epimerase
MDIERVEEVRAVERLAHRRGLALMPRAGLAAADFVAARLPAGGQVLALAGPGNNGGDALVAATLLQARGYRVAVVMPAGPARLPDDARRAWQGWCAAGGQASADLPAHAPALVIDGLFGIGLARPLDEAWQGLIDQVNAWRVPVLALDVPSGLSAASGQPLGDPPGRPVRATWTLSFIGVPAALRAPGAAAWCGEQHLSLLGLTPAFLAEAVGPCGQAAATAARRSGP
>CP020645.1|AWP59661.1|3686054_3686984_+|phenylacetic-acid-degradation-operon-negative-regulatory-protein
MASTPSPLDRFLSRLLKNDPPRAKSLCVSLLGDALAPHGGAIWLGDLIELLAPIGINERLLRTSVFRLVAQGWLQSERHGRRSLYLLSEHGLRHTAHASQRIYDGPARAWNGEWTLVALPRAGNNGLAERGELRRELLWEGFGMVAPGLFAHPQTEARAAHDILEKLGIPDKALVLSARDLAGAGGLPIASLAGQCWNLDEVADQYRLFSRNFGPVEKLLDPPPTPAQAFAVRVLLLHNWRRIVLHDPQLPTPMEPDGWPGNAARALCRRIYWQVFDASERHLDAVAGRENARYRPAQADIMGRFGGRP
>CP020645.1|AWP59660.1|3684893_3685883_-|phenylacetate-CoA-oxygenase-subunit-PaaA
MYAQLVETGVSKVKHVDQLEGPEQAFQRRIDDGVRIEPKDWMPEAYRKTLVRQISQHAHSEIVGMLPEGNWITRAPSLKRKAILLAKVQDEAGHGLYLYSAAETLGVSREDLIDDLHTGRAKYSSIFNYPTLTWADIGMIGWLVDGSAIINQIPLCRCSYGPYARAMVRVCKEESFHQRQGYDLLIQMCLHGTPEQKAMCQEAFNRWWWPALMMFGPSDADSPNSAQSMQWKIKLFSNDELRQKMVDQTVPQAEYLGLTVPDPDLKWNAERGHYDFGAIDWDEFYAVIKGHGPCNRERLAARVKAHEDGAWVREAMVAHADKQARRKAA
>CP020645.1|AWP59659.1|3684544_3684829_-|phenylacetate-CoA-oxygenase-subunit-PaaB
MSKDWPLWEVFIRSQHGLAHKHVGSLHAPDAEMAINHARDVYTRRNEGLSIWVVRAADIVASSPGDKEPLFEPANSKVYRHPTFFPMPDEIKHM
>CP020645.1|AWP59658.1|3683764_3684529_-|phenylacetate-CoA-oxygenase-subunit-PaaI
MDKSLFEYLLRLGDTTLVLSQRLGQWCGHGPVLEEDLALTNTALDLLGQARMWLTLAGEVEGAGRDEDRLAYLRDAPQFRNLLLVERPNGHYGDTMARQFLFDTWHYFLLIRLARSADERVAAIAAKALKEVTYHARRSADLVVRLGDGTALSHARMQAAIDAAWPYVGEMFVDDAIDQDLAARGIACELSSLRDEWLAQVREVLDEATLAMPQEDEAFHPAHRGGRQGRHTEHLGYILAEMQHLQRTYPGASW
>CP020645.1|AWP59657.1|3683261_3683768_-|phenylacetate-CoA-oxygenase-subunit-PaaJ
MNASPRVPAGQVLAWLESVPDPEIPVLSVVDLGVVRDIGWDGDTCVVTITPTYSGCPAMREITHDIETTLAGHGLASVRVETRLAPAWTTDWMTARGRAALRQYGIAAPVERAVDISGISRRRTAPAIECPHCGSLDTRLLSHFGSTSCKALYRCVACREPFDYFKPH
>CP020645.1|AWP59656.1|3682161_3683250_-|phenylacetic-acid-degradation-protein
MSHNPFHMLKVASVARNTRDAVVVTFDLPPELAGDFRFRPGQYLTLRTRLDGEEVRRSYSICSAPGDGVLRVAIKKVDEGVFSNWANHELQPGQSLEVMPPAGNFTVDFDPDNARHYVAFAVGSGITPVFSLVKSALSAEPRSRFTLFFGNRASSSVLFREEIEDLKNLYMERFSLVYIMSRESQDIELFNGRLDGDKVDQLLTAWMRPGDIDYAFVCGPQTMIESVVEHLQARGMPKSRIKFELFGAPKGPRALRTGRDAPAAPGKGQCEVTVVQDGHSRTFFIDKNKDSVLDSALAQGVELPYSCKGGVCSTCRCKVVEGEVDMDANFALEDYEVARGFVLSCQSYPVSDRLVIDFDQET
>CP020645.1|AWP59666.1|3690606_3691761_-|oxidoreductase
MTPPAGVIFPISTARRGAPFFIPAQGASQSGQDLAVKYRKLGHTDLDVSLIGLGTMTWGEQNTEAQAHEQLDYALAHGINLVDAAEMYPVPPKPETQGRTESCIGSWLARTGRRHEVVLASKAAGPVRDAKRPSHIRDGKTFLDRKNLTQALDASLKRLQTDYLDLYQLHWPDRTTNTFGKLAYPWVDDAHTVPIEETLEVLQDFVRAGKVRHVGLSNETPWGVARFLQAAEKHGLPKVATIQNPYNLLNRIFEIGLAEFSHREGVGLLAYSPLAMGILSGKYLDGARPEGSRLALFTRFTRYSNPQAEAAARDYVMLARDHGLAPAQMALAWVNQRPFVSSNLMGATTLAQLKENIESVEVTLSDEVLQGIEAIHARQPNPAP
>CP020645.1|AWP59667.1|3691757_3692483_-|coenzyme-A-pyrophosphatase
MSDSAPSRPRRTPVRPLFDPMAQPWETANQGLARVDERLLTPPELRSSLRPADHWRLDPLCAAEPRAPGREGSLVAAAVLIPLVMRADGVRVMLTQRAAHLHDHAGQVSFPGGRIEVSDATPVAAALREAQEETGLPVQQVEVLGSMPQYFTATGFAITPVVSLVQPDFELAPDAFEVAEVFEVPLSFLMDPANHRLYRAALPDGYVRQYYAMPWQRYFIWGATAGMLRNLYQTVREALPG
>CP020645.1|AWP59668.1|3692891_3693272_-|50S-ribosomal-protein-L19
MNLIAILEQEEIARLTGGNAVTEFAPGDTVVVSVNVVEGTRKRVQAFEGVVIAKRNRGLNSSFIVRKISSGEAVERTFQLYSPQIAGIEVKRRGDVRRAKLYYLRSRSGKSARIKEKLVLKKAKSA
>CP020645.1|AWP59669.1|3693579_3694452_+|multidrug-DMT-transporter-permease
MSYTSLILVVLAAMAHAAWNLLAKRAAMVGPMFVFAYGLAATILYAPWVIWVLAHDGMVWSWPVVLCILASSMLHLGYSLCLQRGYQVADLSVVYPIARGTGPLLSTMGAFTLLSEPATTTGIAGMLCVVGGVLLIATQGRLGMFRQAQAWIGVRWGVVIGLFIAAYTVVDAYGVKMLLIMPVLFDWFTCATRTLMMTPHVLRRRAQYWPAMRGYWHLAIAVGVLSPLGYILVLYALRNGAPLSLVAPAREMSMMLGTLAGMFLLREKVGIGRLAGCLAILAGVVLLGSS
>CP020645.1|AWP59670.1|3694459_3694840_-|hypothetical-protein
MTIATTLDAATSLPTAVPGRTLGALRRLARAWAGAAVPQRKWPFPPTPPGQAQPCTPCTDSQPRSAQAVQPAQARALHAQAELSGAATQAATQVLSTKAKIIDVLLVAVWGAMIPALMWLGAAGGF
>CP020645.1|AWP59671.1|3694993_3696268_-|radical-SAM-protein
MASTEHSFSAGFGSPAAAPAALRGRGAVTNVPHRFQQADRVRVDDGWANPDYTAGSDAAALPSVAEALGQGGRRAIPIAVEGADASPNTCAQAPAPRTSVQAEEARKMLSRNDSPDIPFDVAANPYRGCEHGCVYCYARPTHAYLGYSPGLDFETRLVAKANAVAALRAELARPGYRASPINIGSATDAYQPIERTWRLTRGMLELLLQTRHPLTVVTKNALVERDLDLLQDLARQKLVTVFVSITTLDAAMARTLEPRASAPYRRLQTVRTLAQAGVPVGVLVAPVIPFINDESLEHILQEASAAGACYASYTVLRLPWEVKEVFETWLQAHFPDRAQRVLHRIEDLRNGRRNDTAFGSRMRGTGIWADLLRQRFALATRKLGLNRHRPELDTHRFVPPLEPGLPPARGRREARAQPGQLALF
>CP020645.1|AWP59672.1|3696456_3697755_-|sulfate-adenylyltransferase
MNALNDSFLAGADNGVLRLITAGSVDDGKSTLIGRLLYDSKGVFADQLDAISRAKHKRVAGDGIDFSLLTDGLEAEREQGITIDVAYRYFSTPLRKFIIADAPGHEQYTRNMVTGASTADAAIILVDATRAADGRLLAQTKRHSAIARLLGIKHIVVAVNKMDLVDWDRAVFERIGAAYGELARRLALPAFHILPLSALHGDNVVNLSPHSPWYEGQPLLTLLEGLDLAGDGRDLPLRVPVQWVARHGGERADDFRGYAGRVASGVLRPGDEVVVQPSGVRARVQRVLAFDGELQEAVSGDSVTLILDRDVDVSRGDVLAHAQAPARVGREFDAQLCWLDAQPLNPARRYLLKHGTRLTSAKISAVHTRRDIHELQEVPNADGVLHMNDIGRVSLLTREALATDPYAAIAATGAFILIDEATHQTAAAGMLE
>CP020645.1|AWP59673.1|3697807_3698716_-|sulfate-adenylyltransferase-small-subunit
MSAVMTRSHLDWLESEAIFILREVAAECARPALLFSGGKDSVVLLRLAEKAFRPGRFPFPLLHIDTGHNYDEVIAFRDARAAELGETLLVRSVEDSIARGSVALRRETDSRNAAQAVTLLEAIEELGLDACIGGARRDEEKARAKERIFSFRDEFGQWDPKAQRPELWNLFNTRVHRGENMRVFPISNWTELDVWQYIQRERLALPSIYYSHTREVVRRKGLLVPVTRLTPPAEGETVEQLAVRFRTVGDISCTCPVASDAADPAAIIAETAVTDITERGATRMDDQTSEASMERRKREGYF
>CP020645.1|AWP59674.1|3698765_3699518_-|phosphoadenosine-phosphosulfate-reductase
MMAARPLAAIAGLTAAAAARWHDLQSRLAIIARQYPDAALASSLAAEDMVLTHAIYAGGLDLEVFTLDTGRLHTETLGVLDAVATRYGRAITVYRPDAAAVQAHVDAHGMHAFYESVALRKACCEIRKVEPLRRALAGRGAWITGQRRAQSATRGELPDEERDPVFGLYKFNPLAAWNEADVWSVIRALGIPYNPLHDQGYPSIGCEPCTRAVRPGEDVRAGRWWWESSDSKECGLHAGNRVIQIAARPA
>CP020645.1|AWP59675.1|3699514_3700579_-|sulfate/thiosulfate-import-ATP-binding-protein-CysA
MSIEVRGLSKRFGAFRALDEVSLHIETGELVALLGPSGCGKTTLLRIIAGLESADAGSVLFAGEDATEVDVRQRQVGFVFQHYALFKHMTVFENVAFGLRVRHRSQRPSEARIRAKVLDLLGLVQLDWLADRYPAQLSGGQRQRIALARALAVEPRVLLLDEPFGALDAKVRKELRRWLRRLHDELHVASVFVTHDQEEALEVADRVVLMNAGRIEQVGSPREVWERPATPFVYGFLGDVNQLHGHATRGVWRLGEVALPAPDLPEADNQRAIAYVRPHDIDLARAGTAAPGIPVRLNHVYLAGPSAYLELARQDDQAIIEAQVPEPLFRSLGLKEGEALLAQPRRARVFAVQP

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Crispr_ID: CP020645_12

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_12

4123245-4123326

Orphan

Consensus_repeat	Method
CTGTCCCCGCCGGGACAGGCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_12

>merge|CP020645|12|4123245-4123326|CRISPRCasFinder
CTGTCCCCGCCGGGACAGGCACCCGTCGTGCGCCATGAGCGCCACTGCCAAGACGGCGTCTGTCCCCGCCGGGACAGGCGCC

>CP020645|12|12|4123245-4123326|CRISPRCasFinder
CTGTCCCCGCCGGGACAGGCACC	CGTCGTGCGCCATGAGCGCCACTGCCAAGACGGCGT
CTGTCCCCGCCGGGACAGGCGCC

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP60039.1\|4119092_4119647_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|224168
CP020645.1\|AWP60044.1\|4126571_4126952_-\|thiol-reductase-thioredoxin	unknown	unknown	gnl\|CDD\|239245
CP020645.1\|AWP60034.1\|4114183_4115440_-\|isocitrate-dehydrogenase-(NADP(+))	unknown	unknown	gnl\|CDD\|180792
CP020645.1\|AWP60040.1\|4119684_4120059_-\|hypothetical-protein	unknown	unknown	unknown
CP020645.1\|AWP61218.1\|4127655_4127898_-\|hypothetical-protein	unknown	unknown	unknown
CP020645.1\|AWP60041.1\|4120392_4123143_+\|peptidase-M16	unknown	unknown	gnl\|CDD\|223685
CP020645.1\|AWP60033.1\|4113004_4113985_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340821
CP020645.1\|AWP60036.1\|4116118_4116481_-\|cytochrome	unknown	unknown	gnl\|CDD\|225418
CP020645.1\|AWP60043.1\|4124555_4126481_-\|molecular-chaperone-DnaK	unknown	unknown	gnl\|CDD\|234715
CP020645.1\|AWP60046.1\|4127979_4129068_-\|ferrochelatase	unknown	unknown	gnl\|CDD\|234585
CP020645.1\|AWP60042.1\|4123333_4124455_-\|molecular-chaperone-DnaJ	unknown	unknown	gnl\|CDD\|236757
CP020645.1\|AWP60047.1\|4129125_4130130_-\|HrcA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|234621
CP020645.1\|AWP61217.1\|4117007_4117895_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|223786
CP020645.1\|AWP60045.1\|4126959_4127514_-\|nucleotide-exchange-factor-GrpE	unknown	unknown	gnl\|CDD\|237621
CP020645.1\|AWP60038.1\|4117916_4119089_+\|VWA-domain-containing-protein	unknown	unknown	gnl\|CDD\|226346
CP020645.1\|AWP60049.1\|4131159_4132821_+\|DNA-repair-protein-RecN	unknown	unknown	gnl\|CDD\|223571
CP020645.1\|AWP61219.1\|4133300_4133720_-\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|366663
CP020645.1\|AWP60035.1\|4115642_4116068_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370177
CP020645.1\|AWP60037.1\|4116493_4116847_-\|cytochrome-C	unknown	unknown	gnl\|CDD\|225418
CP020645.1\|AWP60048.1\|4130244_4131144_+\|NAD-kinase	unknown	unknown	gnl\|CDD\|179379

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP60039.1\|4119092_4119647_-\|N-acetyltransferase	gnl\|CDD\|224168	COG1247, COG1247, Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane].	1.87052e-61
CP020645.1\|AWP60044.1\|4126571_4126952_-\|thiol-reductase-thioredoxin	gnl\|CDD\|239245	cd02947, TRX_family, TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox state of target proteins via the reversible oxidation of an active site dithiol, present in a CXXC motif, partially exposed at the protein's surface. TRX reduces protein disulfide bonds, resulting in a disulfide bond at its active site. Oxidized TRX is converted to the active form by TRX reductase, using reducing equivalents derived from either NADPH or ferredoxins. By altering their redox state, TRX regulates the functions of at least 30 target proteins, some of which are enzymes and transcription factors. It also plays an important role in the defense against oxidative stress by directly reducing hydrogen peroxide and certain radicals, and by serving as a reductant for peroxiredoxins. At least two major types of functional TRXs have been reported in most organisms; in eukaryotes, they are located in the cytoplasm and the mitochondria. Higher plants contain more types (at least 20 TRX genes have been detected in the genome of Arabidopsis thaliana), two of which (types f amd m) are located in the same compartment, the chloroplast. Also included in the alignment are TRX-like domains which show sequence homology to TRX but do not contain the redox active CXXC motif. Group II proteins, in addition to either a redox active TRX or a TRX-like domain, also contain additional domains, which may or may not possess homology to known proteins.	1.07863e-05
CP020645.1\|AWP60034.1\|4114183_4115440_-\|isocitrate-dehydrogenase-(NADP(+))	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0
CP020645.1\|AWP60036.1\|4116118_4116481_-\|cytochrome	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	2.60442e-23
CP020645.1\|AWP60041.1\|4120392_4123143_+\|peptidase-M16	gnl\|CDD\|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	3.06874e-64
CP020645.1\|AWP60033.1\|4113004_4113985_-\|hypothetical-protein	gnl\|CDD\|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	3.59109e-14
CP020645.1\|AWP60043.1\|4124555_4126481_-\|molecular-chaperone-DnaK	gnl\|CDD\|234715	PRK00290, dnaK, molecular chaperone DnaK; Provisional.	0
CP020645.1\|AWP60046.1\|4127979_4129068_-\|ferrochelatase	gnl\|CDD\|234585	PRK00035, hemH, ferrochelatase; Reviewed.	3.4326e-159
CP020645.1\|AWP60042.1\|4123333_4124455_-\|molecular-chaperone-DnaJ	gnl\|CDD\|236757	PRK10767, PRK10767, chaperone protein DnaJ; Provisional.	0
CP020645.1\|AWP60047.1\|4129125_4130130_-\|HrcA-family-transcriptional-regulator	gnl\|CDD\|234621	PRK00082, hrcA, heat-inducible transcription repressor; Provisional.	5.93958e-145
CP020645.1\|AWP61217.1\|4117007_4117895_+\|ATP-binding-protein	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	1.30038e-45
CP020645.1\|AWP60045.1\|4126959_4127514_-\|nucleotide-exchange-factor-GrpE	gnl\|CDD\|237621	PRK14139, PRK14139, heat shock protein GrpE; Provisional.	1.18525e-78
CP020645.1\|AWP60038.1\|4117916_4119089_+\|VWA-domain-containing-protein	gnl\|CDD\|226346	COG3825, COG3825, Uncharacterized protein conserved in bacteria [Function unknown].	0
CP020645.1\|AWP60049.1\|4131159_4132821_+\|DNA-repair-protein-RecN	gnl\|CDD\|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	0
CP020645.1\|AWP61219.1\|4133300_4133720_-\|transcriptional-repressor	gnl\|CDD\|366663	pfam01475, FUR, Ferric uptake regulator family. This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.	1.74636e-59
CP020645.1\|AWP60035.1\|4115642_4116068_+\|hypothetical-protein	gnl\|CDD\|370177	pfam08897, DUF1841, Domain of unknown function (DUF1841). This family of proteins are functionally uncharacterized.	2.9417e-76
CP020645.1\|AWP60037.1\|4116493_4116847_-\|cytochrome-C	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	6.05638e-23
CP020645.1\|AWP60048.1\|4130244_4131144_+\|NAD-kinase	gnl\|CDD\|179379	PRK02155, ppnK, NAD kinase.	0

>CP020645.1|AWP60041.1|4120392_4123143_+|peptidase-M16
MRLPLLSRRLNALLVSSFLAFQAGAASLPAGVSEVSSIEGITEYRLANGLRVLLAPDASKPTTTVNMTYLVGSRNENYGQTGMAHLLEHMLFKGTPAIRNALGEFSRRGLQANGSTSSDRTNYFASFAANPETLKWYLGWQADAMVNSLIAKEDLDSEMTVVRNEMESGENNPFRVLMQKMQAAAYQWHNYGKSTIGARSDVENVDIAQLRAFYHEYYQPDNAVLIVAGKFDPQTALADIQSSLGKLPKPKRTLPPEYTVEPVQDGERSVTLRRAGGTPLVAAMYHLPAAGSPDFVGLDLAATILADTPSGRLYHALVPTKLASGVFGFTMDQLDPGLAMFGAQLQPGMDQDKALQTLTATLESLSSKPFSQEELERARSKWLTAWQQTYADPEKVGVALSEAIASGDWRLFFLQRDRVRDAKLDDVQRAAVAYLVRSNRTEGRYIPTEKPQRAPLAQRADLAAVFKDYKGDPNFKAVEAFDPSPANIDKRTLRRTLDLPNGQVELALLPKATRGDRVQAELLIQFGDAEALRGQRVPLAAAAALLDRGTDKLSRQAIQDRLDQLQAEAAINGSGTNLVVNISTLGKNLPDVMALVLDVVRNASFPQDQVEEYKRQAITMVQDAMTDPTALASRALARHNNPWPADDVRYVPTFDEALEQLRSLSRDDLAAVSGKLYGAGRIKFSAVGEFDPAAVEAVLRKGLDGWRSAPAYTRLPDPYRAVPAQQFDIATPDKANAFYISRMPLQLQDTNADYPALYLANFLLGTSETSRLWHRVRETEGLSYNVRSNLSVSSYEPSANWTIYAIYAPQNRARLEKAISEELARALKDGFTDQEVRDGVVALLNYRNLARAQDDVLADTWVNYMQTGRSFQWSADMDRKLEALTPDQVNAALRKYLKPDAFSTAVAGDFTKKSAP
>CP020645.1|AWP60040.1|4119684_4120059_-|hypothetical-protein
MLTDIVTRALSQLLGNSLSGDVIKGRFRYAYASDDGRFVAILGHDLTTYVVDVDAQRYFAECAGVPCGFAGHVLEMEGAQEHGHPWPAVNDLFDLDMDGDEIAWRRCPGAVALAATRQAQSRVA
>CP020645.1|AWP60039.1|4119092_4119647_-|N-acetyltransferase
MNATPSPAPTGATLVDCTHDRHAAAILDIFNDAILTSTALYDYQPRALASMEAWFQAKRQGGFPVVGFEDAAGVLMGFASYGTFRAWPAYKYSVEHSVYVDRRYRGRGLGEALLRALIERARLQQVHVLVGGIDATNAGSVALHRKLGFVHAGTITQAGFKFGRWLDLAFYQLTLDTPLRPVDG
>CP020645.1|AWP60038.1|4117916_4119089_+|VWA-domain-containing-protein
MLIDFFYHLRAHKLPVSVQEYLTLLEALRQRLMAPTLDDFYFLARTALVKDESLYDRYDAAFGAYYRGIAAALPADRDIPLDWLIKEFEKTLTPEEKAAIEAHGWDKLMELFKQRLEEQQERHAGGSKWIGTGGTSPFGNGGYHPEGIRVGGDSAGNRTAVKVWDMRQFRDYDDQLELGTRNFKVALRRLRRFARQGADLELDLDDTIASTARNAGHLDLRLVPERRNTVKVLMLLDVGGSMDDHIARVEELFSAARSEFRHLDVYYFHNCPYENLWQNNRRRQNERFDTWDVLRKYNADWRLIIVGDATMSPYEILQPGGSVEHYNKEAGAVWLRRLLDAWPKAAWLNPEPTASWRYRQSIALLRDIMQDRMYPVTVAGLEQAMRQLSK
>CP020645.1|AWP61217.1|4117007_4117895_+|ATP-binding-protein
MPTSASSSSAPAQSARFEGTDRYVATDDLKLAVNAALTLQRPLLIKGEPGTGKTMLAEEVARALDRPLLQWHIKSTTKAHQGLYEYDAVSRLRDSQLGDEKVRDIRNYIVQGTLWQAFEAPEPVVLLIDEIDKADIEFPNDLLRELDRMEFHVYETRQTVQARHRPLVIITSNNEKDLPDAFLRRCFFHYIRFPDRDTMRDIVGVHYPDIRQDVLRAALDTFFALREAPGLKKKPSTSELLDWLRLLLAEAIPAAEIDAHAATAVPVLAGALLKNEQDVHLLERLGAMARGAQRR
>CP020645.1|AWP60037.1|4116493_4116847_-|cytochrome-C
MKLRISMTRTVSVLAVLASCAIAGPAAAADAAPVGNAQNARDKVSMCIGCHGIPGYKASFPELYHVPMIAGQNAKYIEAALNEYRKGARSHPTMDAVAGSLSDQDIADLAAYYSSLK
>CP020645.1|AWP60036.1|4116118_4116481_-|cytochrome
MKRFTFALAGIVLATAGVSAQAQDVVAGKAVFDKFNCASCHGADAKTSVQPEYPVLAGQHADYLAHALKAYKRGAAGSAATANVRKNPIMGAFAAQLSDQDIRNVAAWLAAQPSDLGVRQ
>CP020645.1|AWP60035.1|4115642_4116068_+|hypothetical-protein
MFNPSRDQVREFFIETWRKHRATEVLTPLESMALDWILEHPEYHGDLESPEAMTAEYPVEHGRTNPFLHLSMHLAIAEQLSIDHPRGIRAAYQRLVGRGDAHQAAHEIMECLGQVVWEAQRLGTPLDSDAYIELIRQRAER
>CP020645.1|AWP60034.1|4114183_4115440_-|isocitrate-dehydrogenase-(NADP(+))
MSYQHIKVPTGGQKITVNADYSLNVPDQVIIPVIEGDGTGADITPVMIKVVDAAVQKAYAGKRKIHWMEVYAGEKATKVYGPDVWLPEETLDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIYAGIEYMAESEQAKDLIQYLQTKLGATKIRFPNTSSIGIKPVSREGTERLVRKALQYAIDNDRASVTLVHKGNIMKFTEGGFRDWGYALAQNEFGAQPIDGGPWCKFKNPKTGREIIVKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIIASMEKSILSKKVTYDFARLLEGATQVSCSGFGQVMIDNM
>CP020645.1|AWP60033.1|4113004_4113985_-|hypothetical-protein
MAKPASDMPPYDKAAALRGLAGARRVALLMAPRLGDTLLMMNMARNLAAHGREVSIFGDYIHGLRDWFPGLDIRPSLSEEQAGQVLPGYDCAAQMHVGWPYALHAHQPNYFYYDAHVVITGRGFVKLFQIRDFCREQLGLAQAGADNGLRPPPQVQPHRSHPRRVALHPTSTGAQRCWAPRHFKELGLRLLHEGYEPNYIVAPHERAEWSWVLDHGLHLPQFPSLSEVAGFIHASGWFIGNESGIGHLASNVGVPTLSLTGRPTRTRAWRPAWSTSRIVYPALIPGGRWRDRLWREWLSPRRVMSAFHKLQADDRRQPVGVPWGKI
>CP020645.1|AWP60042.1|4123333_4124455_-|molecular-chaperone-DnaJ
MAKRDYYEVLGVAKNASDEDLKKAYRKLAMKYHPDRNPDSKEAEEKFKEAKEAYEVLGDEQKRAAYDRYGHAGVDPNAAGMGGGMGGGFADAFGDIFGEIFGAGRRGGGGPQVYRGADLKYALEITLEQAASGFDTEIRVPSWENCDTCHGSGAKAGTSPKTCRTCGGSGAVRMQQGFFSVQQTCPTCHGTGKEITDPCPSCDGVGRTRRNKTLQVKIPAGIDDGMRIRSSGNGEPGINGGPPGDLYVEIHIKQHKIFQRDGDDLHCELTIPFTTAALGGELQVPTLGGKAEISIPEGTQSGKTFRLRAKGIRGVRGSYPGDLYCHVVVETPVRLSDEQKAILRQFEASLNDGGDRHSPQSKSWTDRVKEFFS
>CP020645.1|AWP60043.1|4124555_4126481_-|molecular-chaperone-DnaK
MSKIIGIDLGTTNSCVAVLDGGQVKIIENAEGARTTPSIVAYMDDGETLVGAPAKRQAVTNPKNTLYAVKRLIGRKFDEKAVQKDIDLMPYSIVKADNGDAWVEVRGKKLAPPQVSAEVLRKMKKTAEDYLGEEVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAFGLDKTEKGDRKIVVYDLGGGTFDVSIIEIADVDGEMQFEVLSTNGDTFLGGEDFDQRIIDYIISEFKKEQGVDLSKDVLALQRLKEAAEKAKIELSSSQQTEINLPYITADASGPKHLNLKITRAKLEALVEELIERTIEPCRVAIKDAGVKVSDIDDVILVGGMTRMPKVQDKVKEFFGREPRKDVNPDEAVAAGAAIQGSVLSGERKDVLLLDVTPLSLGIETLGGVMTKMIQKNTTIPTRYSQTFSTADDNQPAVTIKVFQGEREIAAGNKGLGEFNLEGIPPAPRGLPQIEVTFDIDANGILHVSAKDKGTGKENKITIKANSGLSEDEIQRMVKDAEANAEEDHRLAELAQARNQADALVHATRKSLTEYGEKLEAAEKESIEAAIKDLEDILKTGDKAEIDAKVEALSTASQKLGEKMYADMQAQQQAQQQQAADNAKPVDDNVVDADFKEVKRDQ
>CP020645.1|AWP60044.1|4126571_4126952_-|thiol-reductase-thioredoxin
MAAAPFDPAEVFQVFGMRRVDSASFDEQVVQAPGDDLRCVFLWGQDCYNCGIFKQTALLQRQALLALELSWFEADVYADEALGRRFSLHGVPTFVLYRSGKRLGRVTGWPGLPQFSAAMQRLRDGT
>CP020645.1|AWP60045.1|4126959_4127514_-|nucleotide-exchange-factor-GrpE
MTAPQEPVDSTPESGENAATPGLEDDLSAELAALRAELEAAQATVKAQQEQVLRAAAEAENVRRRAQEDVAKARKFGIESFAESLVPVKDSLEAALAQPDQAAQAWREGVEVTLKQLTAAFERNLLKEIAPAQGDKFDPHLHQAISSVPADQPANTVLQLLQKGYVIADRTLRPALVVVSAGQG
>CP020645.1|AWP61218.1|4127655_4127898_-|hypothetical-protein
MNPPRKPTIGTSGPPGHANLEEDQLERELDEALLETFPASDPIAITSEDERDEPDDKVDEALEDTFPASDPPAPAQPGKK
>CP020645.1|AWP60046.1|4127979_4129068_-|ferrochelatase
MFLRLFKYLWPERYLPETPAQDPFDENPPPCGPGRVGVLLVNLGTPDEPTRGAIRQYLGEFLSDPRVIEIPRYLWMPILHGLVLTMRPKKLAPRYAGIWMEEGSPLLVYSQRQAAGVRQGLAARGVHAEVELAMRYGKPSIPAAIAALRERGCDHILAVPLYPQYAASTTATVVDAVTRHAGRLRDQPALRFVKRFHNDPAYVEAQAGRIAEFWQAHGRPQKLVMSFHGLPRYSIELGDPYYRDCLDTARLLRERLGLREDEVEVTFQSRFGSARWLEPYTEPTLAELARQGVTEVDVVCPGFVADCLETLEEISQECRDAFVAAGGRQFRYIPALNDCPPWIEGLTDLVERQLRGWPTGNP
>CP020645.1|AWP60047.1|4129125_4130130_-|HrcA-family-transcriptional-regulator
MDDRARALLKALIERYIADGQPVGSRTLSKVFDLSPATIRNVMADLEELGLIHSPHTSAGRVPTPRGYRMFVDSLLAVRAYQFEPAHIGELLPVSEPSRAVNAAAALLSNLTQFAGVVLTPKRTQIFRQIEFIRLSDKRVLLIIVTPEGDVQNRILSAQRDYTEAELLEAGNFFNVHFSGKSFDAVRRTLSTELAQLRDDISRLMQAAVEAGAEAADDGEAVVISGERKLLDVTDIASDMDRLRKMFSLFEKKTDLLQLLDVSSRAQGVQIYIGGDSQLVPMEEVSVITAPYGLDGKVIGTLGVIGPTRMAYERVIPIVDITARLLSNALSHNQ
>CP020645.1|AWP60048.1|4130244_4131144_+|NAD-kinase
MYFPIVALIGRYQDTGLDAPLTALAQMLTQAGRRVLVEAETARNAGVSGYPVADWDEIGRTATLAVVMGGDGTVLGAARHLAPYGVPLIGINHGRLGFITDIPLQDAHDALGRVLEGNYQAEDRMLLQGGVWRGEQQMYSASAVNDVVLNRAGRGGMIEVRVELDGAFMYTQRADGLIIATPTGSTAYSLSANGPILHPGMNAMVLVPVAPQTLSNRPIVIPDSGVLNMTLTAMGRVEIGASVHFDMQTWSDLQPGDRITVQRAPHTIRFVHPEGYSFFSTLRRKLHWNLMPQATDNLE
>CP020645.1|AWP60049.1|4131159_4132821_+|DNA-repair-protein-RecN
MLRTLHIRDFVIVEQTELHFGDGFTVFSGETGAGKSILIDALALTLGERGDASMLREGAARADITAVFDAPPALRDWLAERELDSGDELALRRVIDSQGRSRAYINGMPATIAQLRELGDGLVDIHGQHAHQSLMRPDAQRDLLDAHGGHAELRQTVAQAWKQWRALARQLDTAEQDAEALAAERDRLQWQSDELDRLGLGPDEWDALQTEHTRLSHAQSLLDGASRILEALDGEHDSAQHRLNGAAHQLQQMLRHDPALQGIGDELESARIAITEAVSDLNNYVSRVELDPQRLADVEARLSAVFETARKFKCEPHDLPALRDSLHGKLAEMQAASDVQALRAQAEAAQARYEAAAARLSAARRKIAKDLGKQVTQAMQTLSMQGGRFEAALTGGAPSAHGSEQVEFLVAGHAGSTPRPLAKVASGGELSRISLALSVIASRAARVPTLIFDEVDSGVGGAVAEAVGKLLRELGQRHQVLCVTHLPQVAACAHAQYRVSKVESGGSTRSRIAELDAEARVEEVARMLGGIKITATTRDHAREMLGGHTAPAA
>CP020645.1|AWP61219.1|4133300_4133720_-|transcriptional-repressor
MSDQSELKNMGLKATFPRLKILDIFRKSDLRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVFELNDGDHHDHLICTNCGTVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLYGICGNCQKGR

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Crispr_ID: CP020645_13

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_13

4475169-4475262

Orphan

Consensus_repeat	Method
GTGCCTGTCCCCGCCGGGACAGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_13

>merge|CP020645|13|4475169-4475262|CRISPRCasFinder
GTGCCTGTCCCCGCCGGGACAGGCACCCGGACCCAGGCCCCCCCCCACGCTGCGCCCGCTGTGCGGGCGTGCCTGTCCCCACCGGGACAGGCAC

>CP020645|13|13|4475169-4475262|CRISPRCasFinder
GTGCCTGTCCCCGCCGGGACAGGCAC	CCGGACCCAGGCCCCCCCCCACGCTGCGCCCGCTGTGCGGGC
GTGCCTGTCCCCACCGGGACAGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP60348.1\|4472332_4472851_+\|methyltransferase	unknown	unknown	gnl\|CDD\|224204
CP020645.1\|AWP60344.1\|4468221_4469193_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270234
CP020645.1\|AWP60351.1\|4475893_4476238_-\|TIGR01244-family-protein	unknown	unknown	gnl\|CDD\|225984
CP020645.1\|AWP60343.1\|4467233_4468211_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176106
CP020645.1\|AWP60356.1\|4480515_4480971_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226610
CP020645.1\|AWP60345.1\|4469259_4470045_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|181723
CP020645.1\|AWP60353.1\|4477926_4478841_+\|EamA-family-transporter	unknown	unknown	gnl\|CDD\|223769
CP020645.1\|AWP60350.1\|4475334_4475805_-\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
CP020645.1\|AWP60347.1\|4471466_4472222_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223930
CP020645.1\|AWP61233.1\|4481990_4482299_+\|sugar-translocase	unknown	unknown	gnl\|CDD\|377229
CP020645.1\|AWP60341.1\|4464880_4465909_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|366103
CP020645.1\|AWP60358.1\|4482258_4483878_-\|phospholipid-carrier-dependent-glycosyltransferase	unknown	unknown	gnl\|CDD\|224720
CP020645.1\|AWP60355.1\|4479586_4480510_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|378820
CP020645.1\|AWP60357.1\|4480967_4482071_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|212118
CP020645.1\|AWP60346.1\|4470037_4471270_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
CP020645.1\|AWP60354.1\|4478837_4479497_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224199
CP020645.1\|AWP60352.1\|4476337_4477738_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224089
CP020645.1\|AWP60342.1\|4465935_4467096_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173841
CP020645.1\|AWP60349.1\|4472847_4474971_-\|elongation-factor-G	unknown	unknown	gnl\|CDD\|234569
CP020645.1\|AWP60340.1\|4463620_4464814_-\|acetyl-CoA-acetyltransferase	unknown	unknown	gnl\|CDD\|180775

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP60348.1\|4472332_4472851_+\|methyltransferase	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	1.24362e-44
CP020645.1\|AWP60344.1\|4468221_4469193_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	1.39784e-117
CP020645.1\|AWP60351.1\|4475893_4476238_-\|TIGR01244-family-protein	gnl\|CDD\|225984	COG3453, COG3453, Uncharacterized protein conserved in bacteria [Function unknown].	3.40043e-35
CP020645.1\|AWP60343.1\|4467233_4468211_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.29992e-59
CP020645.1\|AWP60356.1\|4480515_4480971_-\|hypothetical-protein	gnl\|CDD\|226610	COG4125, COG4125, Predicted membrane protein [Function unknown].	2.35069e-54
CP020645.1\|AWP60345.1\|4469259_4470045_-\|enoyl-CoA-hydratase	gnl\|CDD\|181723	PRK09245, PRK09245, crotonase/enoyl-CoA hydratase family protein.	9.0736e-157
CP020645.1\|AWP60353.1\|4477926_4478841_+\|EamA-family-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.28877e-09
CP020645.1\|AWP60350.1\|4475334_4475805_-\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.38587e-30
CP020645.1\|AWP60347.1\|4471466_4472222_-\|hypothetical-protein	gnl\|CDD\|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	1.14565e-78
CP020645.1\|AWP61233.1\|4481990_4482299_+\|sugar-translocase	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	1.61408e-10
CP020645.1\|AWP60341.1\|4464880_4465909_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|366103	pfam00441, Acyl-CoA_dh_1, Acyl-CoA dehydrogenase, C-terminal domain. C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.	7.97783e-13
CP020645.1\|AWP60358.1\|4482258_4483878_-\|phospholipid-carrier-dependent-glycosyltransferase	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	2.93579e-51
CP020645.1\|AWP60355.1\|4479586_4480510_+\|alpha/beta-hydrolase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	2.97616e-21
CP020645.1\|AWP60357.1\|4480967_4482071_-\|hypothetical-protein	gnl\|CDD\|212118	cd10807, YdjC_like_3, uncharacterized YdjC-like family proteins from bacteria. This subfamily contains many hypothetical proteins, and belongs to the YdjC-like family of uncharacterized proteins from bacteria. The YdjC-family is represented by an uncharacterised protein YdjC (also known as ChbG) encoded by the chb (N,N'-diacetylchitobiose, also called [GlcNAc]2) or cel operon in Escherichia coli, which encodes enzymes involved in growth on an N,N'-diacetylchitobiose carbon source. The molecular function of this subfamily is unclear.	3.026e-93
CP020645.1\|AWP60346.1\|4470037_4471270_-\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.64046e-118
CP020645.1\|AWP60354.1\|4478837_4479497_+\|hypothetical-protein	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	3.59851e-32
CP020645.1\|AWP60352.1\|4476337_4477738_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	1.52472e-110
CP020645.1\|AWP60342.1\|4465935_4467096_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	7.48733e-84
CP020645.1\|AWP60349.1\|4472847_4474971_-\|elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
CP020645.1\|AWP60340.1\|4463620_4464814_-\|acetyl-CoA-acetyltransferase	gnl\|CDD\|180775	PRK06954, PRK06954, acetyl-CoA C-acetyltransferase.	2.70376e-175

>CP020645.1|AWP60349.1|4472847_4474971_-|elongation-factor-G
MTRRTSIERYRNIGISAHIDAGKTTTTERILFYTGITHKLGEVHEGAATMDWMEQEQERGITITSAATTAFWRGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYDSVGGVQPQSETVWRQANKYGVPRIAFVNKMDRVGADFFRVQRQIVERLKGDAVPIQIPVGAEDHFEGVVDLVKMKAIIWDDASQGVRFEYRDIPPELQAQAEQWREKMIEKAAEANEALLEKYLSGQPLSEDEIKSGLRARTVANEIVPMLCGSAFKNKGVQAMLDAVIDYLPSPADVPAIIGHDERDREIERHPADDEPFSALAFKIMTDPFVGQLVFFRVYSGVVKSGDSVLNPLKSKKERLGRILQMHANERREISEVYAGDIAAAVGIKEITTGDTLTDPAHVIILERMTFPEPVISQAVEPRTKADQEKMGIALNRLAQEDPSFRVRTDEESGQTIISGMGELHLEILVDRMKREFGVEANVGKPQVAYRETIRSTVTDVEGKFVKQSGGRGQYGHVVLKLEPQEQGKGYEFVDAIKGGVVPREFIPAVDRGVRETLNTGVLAGYPVVDVKVTLVFGSYHDVDSNENAFRMAASMAFKEGMRRAKPVLLEPMMHVEVETPEDFTGNVMGDLSSRRGMVQGMEDIAGGGGKLVRAEVPLAEMFGYSTSLRSLTQGRATYSMEFKHYAEAPRQVAEQIIAARGSGAAARG
>CP020645.1|AWP60348.1|4472332_4472851_+|methyltransferase
MDTVWTEIWTTVRNEFADIPDVAEATRIVLRLGMAVALGGLLGYERERSGKAAGLRTHMLVALGAALFVLVPLQGGMEVGDLSRVLQGVIAGIGFLGAGAIIKLGNEGEIRGLTTSAGIWLTAAIGVAAGMGREATALASTLIALFVLAALRRLEKRIAARDDKRVVAQPPP
>CP020645.1|AWP60347.1|4471466_4472222_-|hypothetical-protein
MDYLVSLAQQPAAWAALATLIAMEVVLGIDNLIFISILTNKLPPQHQTKARRIGIGMALILRLALLGTVAFIVQLTQPVFELFGHGFSWRDVILVAGGLFLVWKATKEIHHHVDPNPGDDMFGGKAATLGFAAAVAQILMLDLVFSIDSIITAVGMTEHIPIMFVAVIVAVAVMLLAAEPLARFIERNPTVVMLALAFLMMIGMTLIAEGFGAHVPKGYIYAAMAFSALVEGLNMMARRAREGRGAGAAGG
>CP020645.1|AWP60346.1|4470037_4471270_-|CoA-transferase
MSGPLEGVRILDVTTVLMGPYATQILGDLGADVIKVEPPAGDNVRGIGPGRHADMGGIFLHANRSKRSIALDLKKPAGREALLKVAATCDVLVYNVRPQAMARLGLSYAEVAQANPSILYVGMYGYDQRGPYAARAAYDDLIQGAVGIPSLSVEAGSDIPRYAPSAMVDRIVGISAANAVTAGLYHRARTGQGQAIDVPMFETMAHLILGDHMMGQTFEPPLGPPGYPRILNADRRPYATRNGHICVLLYADKHWKAFFELIGQPGRDAADPRFRDIGTRTQHIHAIYRLVSDAIASRTTEEWLAAFEAADIPAMPVHTMASLLRDPHLEAIGFFGTVDHPSEGAVRMMAVPSRWSGTPPQPRGHAPRLGEHSVDVLKEAGYDDEAIAALVRDGAAIAAARQRPEGTDHD
>CP020645.1|AWP60345.1|4469259_4470045_-|enoyl-CoA-hydratase
MTDFLRHERHGGVLLLTMDRERTRNALSDADAVEALVQACARIGADLSVRAVVLTGSHGVFSSGGNLKTLSDTVGAGLGEPVHSRQAYRSGIQRIPLALYNLEVPTIAAVNGPAIGAGCDLACMCDIRLAARQASFAESFVKLGLTPGDGGAWLLPRIVGMSRACELAFTGRSIDAARARELGLVSEVFDADALLPAALALAQEIAQHSGHALRLTKRLLREGQHTRLDTLLELSAGFQALAHHTQEHAGALDAYLSRKRD
>CP020645.1|AWP60344.1|4468221_4469193_-|ABC-transporter-substrate-binding-protein
MHPRTLALAVLSVAALAQGGSARAASDYPAHPVKIIVSLPPGSGADTTARFLSKHLAERFKQPFVVENRPGANSFIAAQAVATAPPDGYTLFVASNSPMTTNAAVFKNLPYDALKDFAPVAPIARFPMALVVPANSPYRSVADLVAAARAAPGQLNFASGTATYQVVLELFHEQNGIKATHVPYKGTSAALADVAGGVVQYSVADVSAALPLIRGGKLRPLAVTSTRRIKDLPDVPTMQESGNKGFEAYAWTAAFFPAKVDPAIVARVSDAVQALVRSEEGKAFMEQLGGEPFVGGPATLAAFQRDELASMRRIAKLANIQQE
>CP020645.1|AWP60343.1|4467233_4468211_+|LysR-family-transcriptional-regulator
MWTGQYIVHIASPAHHWRRAVELRQLKQLLVLSETLNFHRAAERLHMAQPPLSTAIKKLEQELGVQLFERLPAGLQPTPAAEVVLRYARATLFYADEIQRAAQEGASGKQGMLKVGFVGSSVYSLMPQLLSAFRKDYPRVDLVIEESTTVDLLRRLDAHTLDVALVRFPVLEPSTARITLLQADHLMLAVPAGSRYAQRDDVALDELADEPFIGYSRTHVPGMHALVMYAFQQYGVVPHITQEAIQVQTILSLVESGLGLAIVPKVAGRQAGSGVRLVNVPQLAETIKVGIALAVHPDNATPTTANFVDMACRLMQTEPAAGQAR
>CP020645.1|AWP60342.1|4465935_4467096_-|acyl-CoA-dehydrogenase
MGTIIEALQLAAIPARDEALRPAVRAFLDEALREMPADRRARSWMGHDAEFSRALARQGWLGLTLPVEYGGAGRSNFARFVLSEELLAAGAPVSAHWIADRQTAPLILRFGSPAQRAFYLPRIIRGEAFFAIGMSEPDTGSDLASVRTRATPVADGWLLNGRKIWTTNAHRSHYMCALVRTSGAPEDRHRGLSQMIFDLALPGIEIRPIRDIAGDAHFCEVLFDNVLLPHDALVGEEGSGWRQVMAELALERSGPERIYSSMVLLDGWLAHLRRDAAPQRAQVCLAGRLAARLAVLRSMSLAVSQRLEQGADASLAAVLVKDLGTEFEQAVPELIGQALRASPQPAPGDVLMRTLAYLTLINPTFSLRGGTRHILRGIIARELGLR
>CP020645.1|AWP60341.1|4464880_4465909_-|acyl-CoA-dehydrogenase
MVSTMQQDLYETFARALAGLCPLERVRELEAAADPRAGAARTWNEVDALGYGDALSPAEHGGAGLSLADAEGLLRAAGAMALPFPFADTLLARALLRAAGQAVPDGPIALGVALPHGADWRCAPIAGVALAQAVAVEHDGCLALWPAPDVVQPGLFRPRASGAPAWRGMPAQAGRAGAPAGAVQAWRNAADAAGMAGAMQAVLDRCVAYVQERQQFGRALGRFQAIQQDISMLAEQVAAVAMAARLACASGALFPDPALAACARLRACEAVPVVCALAHAVHGAIGITEELPLGLYTARLHEWRATGMSEDDCAELLGRRVLADGERTLLDVVRGMVSAAQA
>CP020645.1|AWP60340.1|4463620_4464814_-|acetyl-CoA-acetyltransferase
MSVHPDPVVIVAARRTPIGAFQGALAHYSAPQLGAHALAAAVRQAGLQPDAAQEALMGCCLFAGLGQAPARQAVLGAGLPTDVQATTLSKMCGSGMKAAMLAHDMLRAGSADVVLAGGMESMSNAPHLIPKARQGYRLGDGQLLDHMYRDGLQDAYEGRLMGHYADLAAREYGFSREQQDAYAHESVLRAQRSVAEGEFAEEIAPMAGLARRGAPAAMVAVDETPGLCDVSRLASLKPVFNADGTVTAGNASSISDGAAALVLTRQAHAERLGLAPQARIVGHATAALPPGQFPAAPVRAIARLFERVGWNRDSVDLFEINEAFAVVTMIALRELGLPAERVNVNGGACALGHPVGATGARLIVTLMHALRRRGLRRGVACLCLGGGEATAIAIERA
>CP020645.1|AWP60350.1|4475334_4475805_-|universal-stress-protein
MFKKILIPTDGSPLSAQAANAGICFARSTGAEVVALHVTQPFAATIGFDGMAAAYAITDEDYEKASAEQAEKYLKLILDRAETAGVKAESRAVSNFNVADGIVQAAGEAGCDLIFIGSHGRSGLSRLLLGSVTAKVLSLAHTAVLVYRVKEDKDKK
>CP020645.1|AWP60351.1|4475893_4476238_-|TIGR01244-family-protein
MSAAIKPLTENFAVAPQLGPADMADVAAAGYKSVIINRPDFEGGPDQPTAADVSQAAQALGLQVEYQPVVGSAMTAADVARFAELLRTMPGPVLAYCRTGTRCTNLFAAAQQLG
>CP020645.1|AWP60352.1|4476337_4477738_-|GntR-family-transcriptional-regulator
MRQADATLVTQLADDLARRIDEHGLRPGTRLPSIRRMAEQSGVSRFTVVEAYDRLVARGLVQSRRGAGFFVRARSASLTALASARVPQAAPETPVRVDVSWLLRNMFRETAAGMPGGAGLLPPEWLDPDMVAAAVRAVGRTVRGNLVSYGSPQGYAPLRQQLASMLQADGVPAHPERNLLTTNGVTHGLDIVARHLIKPGDTVLVEDPAWFVIFGRLAAFGARPVGVPRGPDGPDLAMLDRLAAEHKPRLYIINGAVHNPTGHTLSAGAAYDILRLAERHDFMVVEDDTYADLHPGGAMKLAALDRLERVILVGGFSKMLAASLRVGYIAAGAETLQRLTDLKMLAGLTSPELGERVVHRVLVEGQYRRHIERVRARVNEARLRSIQALQQLGLSVPHEPHAGMFVWADCGRDSEPVARNAAERGMLLAPGTLFSPSGAPSTMLRFSVAMVDTPGIWQSIAAVMAQ
>CP020645.1|AWP60353.1|4477926_4478841_+|EamA-family-transporter
MSPPSAQASAPSASSHAPSWEGYGYGLIGVLVFALTLPMTRLAVGELSPLLVGLGRALLAAVPAAALLWLTRSRRPDRAEWSGIVLAAVGIVVGWPVASTLAMASVPAAHGAVFNGLLPLSTAVFAAWRSGERPSPAFWSFAVLGAVLVAGYALRQGHGALQPGDLWLLLAVVLGGMGYAEGARASRTLGGWRTICWALVVSVPALLPAVLWLAHDAAWPSLPVAGAFAYLAFGSMFLGFFAWYRGLAIGGIARVGQIQLLQPFLTVVAAALLFNEQVEPITYVFAVAVVLVIAGGRRAMVRKA
>CP020645.1|AWP60354.1|4478837_4479497_+|hypothetical-protein
MIGSDLSSLDQAPLASLSVLMPLVLFTLVNSLTPGPNNVMLASSGLTFGFRRTIPHLLGISVGFSIMLLMVGLGLGATLERLPWLYSTLKYGGAAYLLYLAWKIATSGPMESGAERGKPLTFIQAALFQWVNPKAWVMIVSVVATYTPQHGYFANLIIATLVCGVVNLPSVGVWAAFGMALRRWLHRPAAVRTFNVGMAVLLVVSLYPVGLDLLALYTG
>CP020645.1|AWP60355.1|4479586_4480510_+|alpha/beta-hydrolase
MVSLPFRLSWRRMAAVLLLAAGALGFNQLDAWQRQAIFSPQTDQQRWWREPPAGTEVFDLALPNGDKVHAWYWQSPRRDAPTVLYLHGARWNLNGSAFRMEGWTRMGYSMLAIDYRGFGQSTPLLPSEQSASQDAAAALQELARRQPDPARRFIYGHSLGGAIAIDLAARPDLPPFAGLIVESSFTSIGAMLGTMKWGWVPGATLLVTQPFASVDKLAALTTPMLLLHGTADRVVPHTMSDELYRAAQQVPADLKRLVKIEGASHSGAIRSGRIYEDAVADFVRDAGRGYAGRQGAPTPLTASRPGT
>CP020645.1|AWP60356.1|4480515_4480971_-|hypothetical-protein
MSSSSKQTPKTIKERFLHAFFFEIIAIGLSAPVAAWAMDQPLFDMGVLTAVIAWIALLWNMVYNAGFERLERRFGVVRTMPVRVAHAVGFELGLVLIIVPLAAWWLAISFWEAFMLDIGLLMFYLPYAFFYNLAYDKLRARWWGRIEPAGA
>CP020645.1|AWP60357.1|4480967_4482071_-|hypothetical-protein
MTSERYDEGQQPAHDVGPQRGQAGPFHAGDRDGPMGGGRGASDGNEPGNLSQQAAHVEEVSPLRNQAGDVRCRRIAVCGDDFGMNEAIDGALIELAGAGRLSAVSCMPLAPAFAADAPALARLDVDLGVHVDFTEAFAGAAPAAPGLAALLWRAYAGQLDPDWIDARLASQFDAFERAFGRAPDYVDGHQHVHQLPGILPRLRALLKRRYAGQRIWLRHTAPGLQFGLPLAQAAKARLIGALGAGALARAAGQEGWQTNRRMLGVYDFTGGPRRYAGLLHHWLMNARDGDLLMCHPGWPQVHGAAHASQRAAEYEVLAHPELGTWLARNGLRIVRLSQVRGRQASQESGKVRNVPHSGSFRRLASRL
>CP020645.1|AWP61233.1|4481990_4482299_+|sugar-translocase
MEWAGLPPLGANVVGWLLAFVVSFTGHFRLTFRHLAASWTIAARRFFLVSALGFAINELSYAWLLHATSLPYDVLLALVLIGLAFLTFVASRLWAFRHRHAP
>CP020645.1|AWP60358.1|4482258_4483878_-|phospholipid-carrier-dependent-glycosyltransferase
MTLATRSMQPHAVSPGQARSWPLPAAGWLLLAVGVWLAFLSWMRPLALPDEGRYAGVAWDMLRNGSFAVPLIDGMPYFHKPPLYYWLAELSFRLFGVNEWAARLPSALAAWASAVALYLFVRRHRDAASATLCVLVLATLPLFFGGAQYANMDMLVAGMITLCVLAGADTALRARAGQAWRAMALATGVCAALAMLAKGLIGLVLPGAVLLAWLAWRRDWRGLRVLLWPPAILAFAVVAVPWFWLMQVRYPGFFEYFFVHQHFERFAQTGFNNVQPFWFYLPVIAGLALPWSLWAGGLLRKQFWAADADPDGLRRLALVWLAVIVAFFSMPQSKLVGYIMPVLPPLAFLLAEVVMGALRDAAVARATRRMARVSALVAVAICVTAVFVASFNARGSSRELALSLRGELRPDDTLVALHTYPFDLQLYAHAARPMWVVDDWSNPEIPKRDNWRRELYDAVQFEPALGERLLVSADTFQQRLCQAPEGSRYWVWGTAADEEAYAPLRGQAARFADARRSLWLVLVDEAFKGRVCGGTPTGG

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Crispr_ID: CP020645_14

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_14

4749320-4749489

Orphan

Consensus_repeat	Method
GGGTGCCTGTCCCCGCGGGGACAG	CRISPRCasFinder

3 spacers

The CRISPR arrays of CP020645_14

>merge|CP020645|14|4749320-4749489|CRISPRCasFinder
GGGTGCCTGTCCCCGCGGGGACAGATGCCGTCTTGGCCGTCAAGCGTTCTGGCGTATGACGGGGTGCCTGTCCCCGCGGGGACAGGCACTCAGGGCAACTCCGTGGGTGCCTGTCCCCATGCAGGGACAGACACCCGGAATTCCGTGGGTGCCAGTCCCCAGGCGGGGAC

>CP020645|14|14|4749320-4749489|CRISPRCasFinder
GGGTGCCTGTCCCCGCGGGGACAG	ATGCCGTCTTGGCCGTCAAGCGTTCTGGCGTATGACG
GGGTGCCTGTCCCCGCGGGGACAG	GCACTCAGGGCAACTCCGT
GGGTGCCTGTCCCCATGCAGGGAC	AGACACCCGGAATTCCGT
GGGTGCCAGTCCCCAGGCGGGGAC

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP60593.1\|4746938_4747472_+\|YraN-family-protein	unknown	unknown	gnl\|CDD\|173148
CP020645.1\|AWP61238.1\|4742624_4743377_-\|cytochrome-C	unknown	unknown	gnl\|CDD\|225418
CP020645.1\|AWP60591.1\|4745364_4745937_-\|cysteine-methyltransferase	unknown	unknown	gnl\|CDD\|223427
CP020645.1\|AWP60605.1\|4758723_4759287_-\|rod-shape-determining-protein-MreD	unknown	unknown	gnl\|CDD\|274574
CP020645.1\|AWP60598.1\|4750553_4751456_+\|acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|234869
CP020645.1\|AWP60600.1\|4752251_4752827_+\|nucleoid-occlusion-factor-SlmA	unknown	unknown	gnl\|CDD\|181894
CP020645.1\|AWP60589.1\|4743548_4744421_+\|RNase-adaptor-protein-RapZ	unknown	unknown	gnl\|CDD\|235450
CP020645.1\|AWP60594.1\|4747471_4748074_+\|phosphoheptose-isomerase	unknown	unknown	gnl\|CDD\|237567
CP020645.1\|AWP60590.1\|4744417_4745368_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223868
CP020645.1\|AWP60595.1\|4748070_4748814_+\|phospholipid-binding-protein	unknown	unknown	gnl\|CDD\|182907
CP020645.1\|AWP60592.1\|4745933_4746872_-\|rRNA-(cytidine-2'-O-)-methyltransferase	unknown	unknown	gnl\|CDD\|223390
CP020645.1\|AWP60601.1\|4753039_4754533_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|279307
CP020645.1\|AWP60588.1\|4741327_4742614_-\|alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|365823
CP020645.1\|AWP60603.1\|4755624_4756761_-\|rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
CP020645.1\|AWP60606.1\|4759273_4760158_-\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560
CP020645.1\|AWP60599.1\|4751455_4752202_+\|pyrimidine-5'-nucleotidase	unknown	unknown	gnl\|CDD\|319791
CP020645.1\|AWP60604.1\|4756757_4758710_-\|penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
CP020645.1\|AWP60602.1\|4754543_4755599_+\|lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|376860
CP020645.1\|AWP60597.1\|4749503_4750292_-\|methionine-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|224381
CP020645.1\|AWP60596.1\|4748810_4749302_+\|thioredoxin	unknown	unknown	gnl\|CDD\|239264

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP60593.1\|4746938_4747472_+\|YraN-family-protein	gnl\|CDD\|173148	PRK14685, PRK14685, hypothetical protein; Provisional.	3.43572e-88
CP020645.1\|AWP61238.1\|4742624_4743377_-\|cytochrome-C	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	2.70415e-12
CP020645.1\|AWP60591.1\|4745364_4745937_-\|cysteine-methyltransferase	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	9.34456e-53
CP020645.1\|AWP60605.1\|4758723_4759287_-\|rod-shape-determining-protein-MreD	gnl\|CDD\|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	7.62373e-19
CP020645.1\|AWP60598.1\|4750553_4751456_+\|acetylglutamate-kinase	gnl\|CDD\|234869	PRK00942, PRK00942, acetylglutamate kinase; Provisional.	1.71108e-158
CP020645.1\|AWP60600.1\|4752251_4752827_+\|nucleoid-occlusion-factor-SlmA	gnl\|CDD\|181894	PRK09480, slmA, division inhibitor protein; Provisional.	1.59741e-107
CP020645.1\|AWP60589.1\|4743548_4744421_+\|RNase-adaptor-protein-RapZ	gnl\|CDD\|235450	PRK05416, PRK05416, RNase adapter RapZ.	1.18739e-149
CP020645.1\|AWP60594.1\|4747471_4748074_+\|phosphoheptose-isomerase	gnl\|CDD\|237567	PRK13936, PRK13936, phosphoheptose isomerase; Provisional.	1.25469e-125
CP020645.1\|AWP60590.1\|4744417_4745368_+\|hypothetical-protein	gnl\|CDD\|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	4.71697e-55
CP020645.1\|AWP60595.1\|4748070_4748814_+\|phospholipid-binding-protein	gnl\|CDD\|182907	PRK11023, PRK11023, divisome-associated lipoprotein YraP.	4.90725e-43
CP020645.1\|AWP60592.1\|4745933_4746872_-\|rRNA-(cytidine-2'-O-)-methyltransferase	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	1.0339e-108
CP020645.1\|AWP60601.1\|4753039_4754533_+\|hypothetical-protein	gnl\|CDD\|279307	pfam00939, Na_sulph_symp, Sodium:sulfate symporter transmembrane region. There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.	2.68833e-115
CP020645.1\|AWP60588.1\|4741327_4742614_-\|alcohol-dehydrogenase	gnl\|CDD\|365823	pfam00034, Cytochrom_C, Cytochrome c. The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.	1.82878e-10
CP020645.1\|AWP60603.1\|4755624_4756761_-\|rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	3.23854e-160
CP020645.1\|AWP60606.1\|4759273_4760158_-\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	9.0892e-90
CP020645.1\|AWP60599.1\|4751455_4752202_+\|pyrimidine-5'-nucleotidase	gnl\|CDD\|319791	cd02604, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to Saccharomyces cerevisiae Phm8p and Sdt1p. This family includes Saccharomyces cerevisiae Phm8p (phosphate metabolism protein 8) and Sdt1p (Suppressor of disruption of TFIIS). Phm8p participates in the ribose salvage pathway, it catalyzes the dephosphorylation of nucleotide monophosphates to nucleosides, its preferred substrates are nucleotide monophosphates AMP, GMP, CMP, and UMP. Phm8p is also a lysophosphatidic acid phosphatase, dephosphorylating lysophosphatidic acids (LPAs) to monoacylglycerol in response to phosphate starvation. Sdt1p is a pyrimidine and pyridine-specific 5'-nucleotidase; it is an NMN/NaMN 5'-nucleotidases involved in the production of nicotinamide riboside and nicotinic acid riboside, and is a pyrimidine 5'-nucleotidase with high specificity for UMP and CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.14842e-46
CP020645.1\|AWP60604.1\|4756757_4758710_-\|penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
CP020645.1\|AWP60602.1\|4754543_4755599_+\|lactate-dehydrogenase	gnl\|CDD\|376860	pfam02615, Ldh_2, Malate/L-lactate dehydrogenase. This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyzes the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyzes the reactions: (S)-malate + NAD(+) <=> oxaloacetate + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively.	3.52374e-125
CP020645.1\|AWP60597.1\|4749503_4750292_-\|methionine-ABC-transporter-substrate-binding-protein	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	1.17353e-136
CP020645.1\|AWP60596.1\|4748810_4749302_+\|thioredoxin	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.58284e-41

>CP020645.1|AWP60596.1|4748810_4749302_+|thioredoxin
MKKIALVLIIAVAAGIGGWFMWRPAQTAPDVAFTTLEGQKITMQDLRGKVVLVKFWATSCVTCVKQMPDNIANYNQYHPQGYETIAVAMNYDPPNYVLNFAQTRKLPFPVALDTSGELAQAFGNVRLTPTAFLIDKQGQIIKRYLGEYDKAEFQATVQKALAG
>CP020645.1|AWP60595.1|4748070_4748814_+|phospholipid-binding-protein
MMPDAKTAARPLLLAAALSAAALSLSACAPLVIGGAAATTAVVVTDRRTSGVQLEDQNIAFKAESQIAQKLGNTARVNAMVYGGHVLLTGDAPTEEAKAQATAIAQSIENVKAVTNQLTVGPAADFSTRSNDTWLTSKVKTALINTKYVPSGTISVTTSRGVVYLMGKVTQAEGDYAANAAAGVGGVARVVKLFETISREEAIRLSGSGTKSGEGSSDGTAAQKAPIESGAAPAGSGSNGVEAIPIK
>CP020645.1|AWP60594.1|4747471_4748074_+|phosphoheptose-isomerase
MRAMDMTSRMTSHFRDAMALCEQSADALAAPLAAAVDLLFAALANNGRILACGNGGSAADAQHFIAELVGRFERERLPLAGIALNTDTSIMTAVGNDYGFDEIFERQVHALGQPGDVLVAISTSGNSPNVVRAMETAREREMHVIALTGKGGGVMGELITPHDVHLCVPHDRTMRIQEVHIILLHALCDGIDALLLGDTE
>CP020645.1|AWP60593.1|4746938_4747472_+|YraN-family-protein
MTDTATRLAFARAAQAQRRLHRRPPASPRASPGARGGGSPTQRRGQAYESAALRWLARQGLRPLARNLRCRAGEIDLAMRDGEVLVLVEVRARAHAGYGGAAASIGASKQGRLARAAALLLPVLLRRHWPGAPPPVRFDVVAFEAGRPHWLRGAFWLAEHAPAQGRRGQDAQGWRVR
>CP020645.1|AWP60592.1|4745933_4746872_-|rRNA-(cytidine-2'-O-)-methyltransferase
MNQDVLSPAPGDAWSRVADRVAAQHWPAATLYVIATPIGNLGDLGLRAWQALVRADVIAAEDTRASRTLLDAWGVSTPLMAAHRHNEASAAQAICERLAQGQRVALVSDAGAPAVSDPGARIVRAVREAGYAVVPVPGPSAVIAALMGSGATSDENPAFAFAGFPPVKAVARQRWLRQWCALPAPVVMFESPHRLAATLADLREAGGPARLLTVARELTKRFEEIATMPLGEAADWLAADAHRGQGEFVLIVHQAPGAQDDEADPADPRTDALLDALLESLSVRDAARVAAKVTGLARDVLYARALARKEQP
>CP020645.1|AWP60591.1|4745364_4745937_-|cysteine-methyltransferase
MNPPSAQATDILYCDTDTPLGPMRLAARGQALCGAWFVDQRDCPAAAGWTLDAAHPALRQAAAELEQWFAGRRRAFEVAMQPEGTPFQRQVWQALLELPFGATISYGELARRVGRPKAARAVAGAVGRNPISILIPCHRIIGHDTSLTGFGGGLPRKQALLAHEGHRYLSRAARARRVSTTQMELPLGAA
>CP020645.1|AWP60590.1|4744417_4745368_+|hypothetical-protein
MIRSRPLALLSTLLLALAIAGCSTPGKKRGGYYKDDGPDANPPSNLDNVPDATPRLEPLASGPNRPYVVFGKRYVPDTSERPFRQQGLASWYGKKFHGNSTSNGESYDMYAMTAAHPTMPIPSYARVTSKINGRTVIVRVNDRGPFHSDRIMDLSYVAAHKLGIIGPGSGPVTVERILPAEILAMNGGAAAPRPGPASATGPLPVAAPSAAAAVELHPATQLASNAPTPPRPAAGTGSGIYLQLGAFSQPANAESLVSRINGQLDPASGIPPAVVEQANNLYRVRIGPYATREAALGAVQPVADRTGILPSLSATP
>CP020645.1|AWP60589.1|4743548_4744421_+|RNase-adaptor-protein-RapZ
MLRVVLITGISGSGKSVALRLLEDAGFTCIDNLPVRFLAEFIANARDDAMERVAVAIDVRSPGELAELPDVITASRAMGTSLSVIFLDANTDTLVQRYSESRRRHPLTDRLARGGKTPSLAECIALERELMAPLRDQEHVIDTSDLTPGQLRAWIRDLIQADRPPLVLTFESFAYKRGVPSDADLMFDVRCLPNPYYDRTLRPLTGRDEPVATWLGGFDIVTQMIDDIAAFIRRWLPQYTQDTRNYLTVAIGCTGGQHRSVYVVEQLARRFSDHDPLLVRHRTQLPDDPA
>CP020645.1|AWP61238.1|4742624_4743377_-|cytochrome-C
MLAFKSDLRIAMRAWRAACGVLAAAAGMLAMPQAVAQGEAALRPDTMAARVAACTACHGEQGRAGPDGYYPRLAGKPQDYLYHQLLNFRDARRQYPPMAHLLNGLPDAYLREMAAYFAGQDVPYPPPARIEASAALVERGRLLVREGDPARAIPSCASCHGASLAGVAPAIPGLLGLPRDYLVAQIGSWQNGLRRAAEPDCMAQVSLKLTPEDIGAVSAWLAGQPVGHPYTPQPAGSLTLPLECGSQAGH
>CP020645.1|AWP60588.1|4741327_4742614_-|alcohol-dehydrogenase
MKIIKRVLVVVILALLAAVATLYWLGTRDHVPAGPQAAPATGSADELVEQGRYLARAGNCMACHTARGGQAYAGGTPIPTPFGTLYGPNITPDAETGIGGWSADDFWQALHNGKGPGGRLLYPAFPYTEYTRMTRADADALYAFLRSVEPVRQASRPHELASPYDQRLLLAAWRALYFEPGGPQADPGQSLQWNRGRYLTEGLGHCAACHTPRNSLGATRAAEALGGGMIDGLGWYAPPLTGQPGTGLGDWSAQDIAALLTTGIALHSTVAGPMAEVVLGSTQYLSGEDALAIGTYLKSLPAAAPPPARRGAPSATVMELGGKLYSQNCAQCHQADGKGSFPAWPALAGNPSVIAAEPANVIRMVLDGGFAPATAANPRPHGMPPFAQALPDNDIAMLVSYVRNSWGNQAGAVTPLDVKRTRESGAGR
>CP020645.1|AWP60597.1|4749503_4750292_-|methionine-ABC-transporter-substrate-binding-protein
MRMNFVRSALLASAFLLAGGAAQAEKLVVGATQVPHAEILEVVKPALAKEGVELDIKVFTDYVQPNLQLADKQLDANFFQHQPYLDTFNKDRKTNLVSVGLVHVEPFGGYSKKIKSLAELKDGATIAIPNDPSNSGRALLLLQKQGLLKLKDPSNIVATPIDIAENPKKLKFRELEAAMLPRSLDDLDLALINTNYALEAGLVPTRDALFIEGADSPYANLVAARPDNKDAPAVKKLVNALHSEAVRKFIIEKYKGAVVPAF
>CP020645.1|AWP60598.1|4750553_4751456_+|acetylglutamate-kinase
MTDTPDPAAVLSPAVKAAVLSEALPYIRRFHGKTIVVKYGGNAMTEERLQRSFAHDVVLLKLVGLNPVVVHGGGPQIDDALRRIGKQGTFVQGMRVTDAETMEVVEWVLGGQVQQDIVMMINEVGGKAVGLTGKDGMLIQATKKLMVNKDDPSQPLDIGFVGDITRVEPAVVKALQDDQFIPVISPIGYGEDGTAYNINADVVAGKMAEVLGAEKLLMMTNTPGVLDKGGKLLRSLSAQTIDELFADGTISGGMLPKISSSLDAAKNGVNSVHIVDGRVPHCLLLEILTDQGVGTMISSH
>CP020645.1|AWP60599.1|4751455_4752202_+|pyrimidine-5'-nucleotidase
MQARRYLLRPAARLRRSRRIATAAPERLWLFDLDNTLHDTSHAIFPLIDRGMTEAVAETLAVDEATANRLRAEYWRRYGATVIGLVRHHGVDADAFLHRSHNFEVAPLVRAETALADKLRRLPGRKVLLTNAPLHYARAVLRHLGLLRQFDSIWAIEQMRMHGQFRPKPSDALLRYVLAREGVPAARAVLIEDTLDNLRSARRVGLRTVHVFHPGTPFARGHRQRPGYVDLRVNSVSDLLLRRRPLRG
>CP020645.1|AWP60600.1|4752251_4752827_+|nucleoid-occlusion-factor-SlmA
MASKPGERKTQILHTLAEMLEQPHAARITTSALAARMQVSEAALYRHFASKAQMFEGLIEFIETSIFTVVNQIAVSEPYGMGQARKTVAMLLAFAERNRGITRVLTGDALVTEDNRLQERINHINDRIEASLKQCLRVAVSDGALPADANIAAHASLLTHLVLGRWLRYAQSGWRVAPTTHLEEHLRLALG
>CP020645.1|AWP60601.1|4753039_4754533_+|hypothetical-protein
MTAPAAVPAPQSPPKVKIPIGLIAGIIAMVVVLLLPLPAELPPAGHRMLAILAFAVVVWITEAVSYEASAIMITTLMAFLLGTAPNVKNPDVLYGTSAAISMALTGFSNSALALVTGALFIAAAMTFTGLDKRIALVTLARVGTSTRRILLGAIAVTIVLSLVVPSATARSAAVVPIMLGVIAAFGVDKRSNIAAGIMIIVAQATSIWNVGIQTAAAQNLLTVGFMDKMLGERVAWSDWLIAGVPWSLLMSAVLIFVVLRLLPPESDAIAGGKEAVEASLRELGPMTSAQKRLMLVSIMLLLFWSTEGKLHKFDTTSTTYFGLVLLMLPRFGVMTWKDVQTRIPWGTVIVFGVGISLGTALLTTQAGQWLGAQVVAHTGLDHLGPLGIFAILSAFLILIHLGFASATALTSAMLPILIAVLQTLPGDFNRLGMTMLLGFVVSYGFILPINAPQNMVALGTETFTAKQFAKVGIVLTIVGYLLMLLMSVTYWRWLGWM
>CP020645.1|AWP60602.1|4754543_4755599_+|lactate-dehydrogenase
MKLSIAQAIAFGQRLLAAQGVPDDIARDVAEHLVESDRVGYTSHGLSILPNYRRVLAEGFVKADGRAKLLNDRGAMLAFDGDNGFGQHVGKAVMQQAIERARQYGQCIVTLRRTHHLGRMGYYGEMAAEAGLILLAFTNVVNRPPTVAPYGGAQACLTTNPLCFAGPLPGGRPPFLVDMATSSIAVNKARVLAARGEPAPDGALIDAQGNPTNDPNALFADPPGALLPFGGHKGYAMGLVAELLAGVLSGGGTIQPEHPRNGVATNNMFAILLDPQVDFNADWRTQEVGAFIDYLHACPPQPGVDRVQYPGEYEAMNRARHAEAIEFEGAIWGSLAKLAQDLGAADALPRA
>CP020645.1|AWP60603.1|4755624_4756761_-|rod-shape-determining-protein-RodA
MKRLGLILLRVFTAFDWPLLLILILFTLLGLTVMHSAVGSTDWRFAEQSRNFLIAFAAMWAMALVPPNTLMKLALPFYVLGVILLLGVEFFGETSKGATRWLNLGVTRIQPSEMMKIAVPMMLAWYFQRHDGAVRIRDFFVAAAMLAAPFVLIVLQPDLGTALLVFGAGFFVIYFAGLSFKLLVPCLLAGIIAIGTLIYYEDQLCEPEVDWVVLHDYQKHRVCTLLNPSSDPLGKGFHTIQSMIAVGSGGLYGKGYMQGTQTHLDFIPERTTDFIFAVYAEEFGLYGGVALLVLYGLFMARGLAIASRASSQFGRLLAGAITMMMFIYVFVNVGMVTGILPVVGVPLPFMSYGGTALLTMGIACGILMSISRRRPAPA
>CP020645.1|AWP60604.1|4756757_4758710_-|penicillin-binding-protein-2
MFEFKKTGQQQKQRFRLRAWVGGLFALACFGVLAGRFWYLQVDRYEGFSERADRNRIAVVPIPPRRGEILDRNGEVLARNYRTYTLEVVPAQAGNLDQLFDRLARVVYISPSDQRRFKRRVGESSRYASLQLRNNLNDTEAAWFSAHSFEFPGVELRARWVREYPQGEAAAHVVGFIGRIAENDIEELDKAGQLGNYRGTDVIGKKGIEKTWEAALHGRTGLEEVEVTAGGRPMRTLRRIDPVPGSDIMLSIDLELQKLAEQAFEGRRGALVALDPDTGEVLAFVSQPSFDPNLFVDGIDVENWRRLNESPDHPLINRPLYGTYPIGSTYKPFVALAALELGKRRATDRMPDPGYFEFGGQKFRNAGGAAYGMTDMHRAIVVSSDTYFYSLGPEIGVNALHDFSKQFGFGQITGIDLEGEKAGVLPSTEWKRKAYKDRDRQRWYAGETISVAVGQGYNSFTLLQLAQATSTLANSGLYRRPHLVHAIRDSRSGSVNPTEIAPDYRIPLKQENVDVIKRAMADVVRAGTARRAFAGAPYQAAGKTGTAQVFSLRGGQYRASAIDERLRDHALFMGFAPVEQPRIAVALIVENAGWGASAAAPIARTLFDNWLGRADAPSVVRAGAKPVAAEPEAAALELGATDGPMQERRQ
>CP020645.1|AWP60605.1|4758723_4759287_-|rod-shape-determining-protein-MreD
MERTKVSVPARRKLGTPSNVEPERLARPAHGVFVWGTVLLVWLLSLLPWRQWPGSPDVLVLVIAFWCVHEPRRVGLLTAFVFGLLLDVHDAGLLGGHALSYTLTAYGAIALHRRLQRFDLWSQAMHMLPVFFLAQLVTQIILAWLAGKWPGWQWAVSVGLTVAIWPLAGWVLHMPQRRYDDVESSAV
>CP020645.1|AWP60606.1|4759273_4760158_-|rod-shape-determining-protein-MreC
MQRQATPPLFRRGPPAEVRLAVLVILALALLIVDSQLRVLEPVRRAVSVALYPFQRAVMAPRDLVQQVDEWINAASLIRSENEALQRQRIELAQVATHAAQLAAENAQLRRLLGVTDTVAQSAVVVEVLYEPPNAFHQRLVFNKGAKSGLAPGMPVIDEGGVVGQIVRVTPMTAEAALVTDERVSIPVQVLRNGLRLIAFGANTPGVIEVRYLAANADIKVGDTIVTSGVGGLFPAGLPVAKVASVERDTASGFARALGEPLAHPERYRHFLVLQVDVDQAESNRQEADVDGAD

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Crispr_ID: CP020645_15

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_15

4814590-4814676

Orphan

Consensus_repeat	Method
CTGTCCCCGCCGGGACAGGCACACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_15

>merge|CP020645|15|4814590-4814676|CRISPRCasFinder
CTGTCCCCGCCGGGACAGGCACACTGCCGTACGCCATCGACGCTTGACCGCCAAGACGGTATCTGTCCCCGCCGGGACAGGCACCTC

>CP020645|15|15|4814590-4814676|CRISPRCasFinder
CTGTCCCCGCCGGGACAGGCACACT	GCCGTACGCCATCGACGCTTGACCGCCAAGACGGTAT
CTGTCCCCGCCGGGACAGGCACCTC

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP60650.1\|4806053_4806644_-\|cysteine-dioxygenase	unknown	unknown	gnl\|CDD\|227840
CP020645.1\|AWP60655.1\|4812442_4812946_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|259873
CP020645.1\|AWP60659.1\|4817669_4818818_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
CP020645.1\|AWP60653.1\|4808901_4809636_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|119339
CP020645.1\|AWP60660.1\|4818862_4819525_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380061
CP020645.1\|AWP60649.1\|4804691_4806020_+\|amidase	unknown	unknown	gnl\|CDD\|223232
CP020645.1\|AWP60656.1\|4813460_4814441_+\|cytochrome-c5-family-protein	unknown	unknown	gnl\|CDD\|225784
CP020645.1\|AWP60661.1\|4819638_4820631_+\|nitronate-monooxygenase	unknown	unknown	gnl\|CDD\|224981
CP020645.1\|AWP60666.1\|4823875_4825504_+\|transporter	unknown	unknown	gnl\|CDD\|173863
CP020645.1\|AWP60657.1\|4814729_4816244_-\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|236211
CP020645.1\|AWP60658.1\|4816327_4817557_-\|CoA-transferase	unknown	unknown	gnl\|CDD\|224717
CP020645.1\|AWP60648.1\|4803471_4804617_+\|transporter	unknown	unknown	gnl\|CDD\|380643
CP020645.1\|AWP60652.1\|4807744_4808905_+\|CoA-transferase	unknown	unknown	gnl\|CDD\|367110
CP020645.1\|AWP60662.1\|4820627_4821365_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|235852
CP020645.1\|AWP60664.1\|4822354_4823215_+\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576
CP020645.1\|AWP60663.1\|4821444_4822266_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|235991
CP020645.1\|AWP60654.1\|4810624_4812400_-\|copper-oxidase	unknown	unknown	gnl\|CDD\|273649
CP020645.1\|AWP60665.1\|4823342_4823579_+\|hypothetical-protein	unknown	unknown	unknown
CP020645.1\|AWP60651.1\|4806933_4807728_+\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
CP020645.1\|AWP61241.1\|4809642_4810578_-\|copper-resistance-protein-B	unknown	unknown	gnl\|CDD\|377498

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP60650.1\|4806053_4806644_-\|cysteine-dioxygenase	gnl\|CDD\|227840	COG5553, COG5553, Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only].	6.40342e-49
CP020645.1\|AWP60655.1\|4812442_4812946_-\|hypothetical-protein	gnl\|CDD\|259873	cd04211, Cupredoxin_like_2, Uncharacterized Cupredoxin-like subfamily. Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins because they have an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. Majority of family members contain multiple cupredoxin domain repeats; ceruloplasmin and coagulation factors V/VIII have six repeats; Laccase, ascorbate oxidase, and spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase and the periplasmic domain of cytochrome c oxidase subunit II.	8.66768e-62
CP020645.1\|AWP60659.1\|4817669_4818818_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	3.56115e-148
CP020645.1\|AWP60653.1\|4808901_4809636_+\|enoyl-CoA-hydratase	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	6.2421e-36
CP020645.1\|AWP60660.1\|4818862_4819525_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|380061	pfam17932, TetR_C_24, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in family members such as HTH-type transcriptional repressor KstR2 as well as fatty acid metabolism regulator proteins. In Mycobacterium smegmatis, KstR2 is involved in involved in cholesterol catabolism, while YsiA in Bacillus subtilis is involved in fatty acid degradation.	1.06275e-27
CP020645.1\|AWP60649.1\|4804691_4806020_+\|amidase	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	7.09028e-140
CP020645.1\|AWP60656.1\|4813460_4814441_+\|cytochrome-c5-family-protein	gnl\|CDD\|225784	COG3245, CycB, Cytochrome c5 [Energy production and conversion].	4.08911e-26
CP020645.1\|AWP60661.1\|4819638_4820631_+\|nitronate-monooxygenase	gnl\|CDD\|224981	COG2070, COG2070, Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only].	2.78466e-76
CP020645.1\|AWP60666.1\|4823875_4825504_+\|transporter	gnl\|CDD\|173863	cd08498, PBP2_NikA_DppA_OppA_like_2, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
CP020645.1\|AWP60657.1\|4814729_4816244_-\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|236211	PRK08268, PRK08268, 3-hydroxy-acyl-CoA dehydrogenase; Validated.	0
CP020645.1\|AWP60658.1\|4816327_4817557_-\|CoA-transferase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	2.87761e-177
CP020645.1\|AWP60648.1\|4803471_4804617_+\|transporter	gnl\|CDD\|380643	cd19988, PBP1_ABC_HAAT-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems predicted to be involved in uptake of amino acids or peptides. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in the uptake of amino acids or peptides. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, its ligand specificity has not been determined experimentally.	1.28709e-110
CP020645.1\|AWP60652.1\|4807744_4808905_+\|CoA-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	2.21282e-158
CP020645.1\|AWP60662.1\|4820627_4821365_+\|enoyl-CoA-hydratase	gnl\|CDD\|235852	PRK06688, PRK06688, enoyl-CoA hydratase; Provisional.	1.11694e-74
CP020645.1\|AWP60664.1\|4822354_4823215_+\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	3.8144e-73
CP020645.1\|AWP60663.1\|4821444_4822266_-\|enoyl-CoA-hydratase	gnl\|CDD\|235991	PRK07327, PRK07327, enoyl-CoA hydratase/isomerase family protein.	0
CP020645.1\|AWP60654.1\|4810624_4812400_-\|copper-oxidase	gnl\|CDD\|273649	TIGR01480, unnamed_protein_product, copper-resistance protein, CopA family. This model represents the CopA copper resistance protein family. CopA is related to laccase (benzenediol:oxygen oxidoreductase) and L-ascorbate oxidase, both copper-containing enzymes. Most members have a typical TAT (twin-arginine translocation) signal sequence with an Arg-Arg pair. Twin-arginine translocation is observed for a large number of periplasmic proteins that cross the inner membrane with metal-containing cofactors already bound. The combination of copper-binding sites and TAT translocation motif suggests a mechansism of resistance by packaging and export. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds].	0
CP020645.1\|AWP60651.1\|4806933_4807728_+\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.29699e-70
CP020645.1\|AWP61241.1\|4809642_4810578_-\|copper-resistance-protein-B	gnl\|CDD\|377498	pfam05275, CopB, Copper resistance protein B precursor (CopB). This family consists of several bacterial copper resistance proteins. Copper is essential and serves as cofactor for more than 30 enzymes yet a surplus of copper is toxic and leads to radical formation and oxidation of biomolecules. Therefore, copper homeostasis is a key requisite for every organism. CopB serves to extrude copper when it approaches toxic levels.	1.92855e-103

>CP020645.1|AWP60656.1|4813460_4814441_+|cytochrome-c5-family-protein
MLCSDWIVSCRLLGVPRYPDSQDLVMSNEQEHIEEHVSPIKTPKQLITTIVLAFVVPIIIIIMLVNVVTSGTKVGAGSDTLGEEAVAKRIAPVAGFELVDANAPKVHKTGEQVFTAVCTACHTAGVAGAPKMGDNAAWAPFIKAGYDAMLNVALHGKGGMPAKGGNPALSDYEVARAVVYMANQSGGSLPEPAAPAEEGAKPAEAAAPAAAAAPAPAPAAPAAAAPAPAAAAAAAPAAPAEQQAAVNPAGEKLYKATCFACHATGVANAPKFGDKAAWAPYIQTGMDAMLKVAMQGKGAMPPKGGAATASEDDIRAAIEYMVNAAK
>CP020645.1|AWP60655.1|4812442_4812946_-|hypothetical-protein
MRARVYAVRMAAAAAACGISFGAAASGAHGGGHGGGHGAATAGATAIGKPGVASKASRTVNVDMTDAMRFTPDQIEVKAGETVRFKVTNSGKIRHEMVLGTDADLGAHYQMMLKDPGMRHEEPNSVSLDAGKSGEIVWQFDKAGRVAFGCLEPGHYPAGMKGAVSVK
>CP020645.1|AWP60654.1|4810624_4812400_-|copper-oxidase
MSRAVSNQRRRFVQGLAGGGVLAGLGLWRQAAWAQPGAAQPEVLSGTEFNLEIGRTPANFTGAARMATTVNGSIPAPILRWREGDTVTLRVTNRLDEDTSIHWHGILLPTGMDGVPGLSFPGIRPGETFTYRFQVRQSGTYWYHSHSGFQEQTGLYGAIVIEPRRADPVRAERDHVVLLSDWTDEDPMSVFRKLKVMPDYYNYIQPTVDNLIDDARKQGWASALGERLMWQQMRMNQTDLADVSGATYTYLANGKSPAGNWTGLFKPGERVRLRFINGSAMTYFDVRIPGLKMTVVAADGLPVRPVEVDEFRIAVAETYDVIVEPAEDRAYTIFSQAMDRSGYARATLAPREGMQAEVPALDPVQVLTMMDMGMAHDMPGMDHGAAGQQGAAMDHGAMGGMDHAAMGHGSGEASGGMVEVRHPYPAEHGPANSMLPDIVTTRLDDPGVGLRDNGRKVLTYADLRSMVEPEDNRAPTREIELHLTGNMDRYMWSFNGLKFSQAKPIVLKYGERVRFVLVNDTMMTHPIHLHGLWSDLESPDGNFQVRKHTISLNPAQRISYRVSADARGNWAYHCHLLYHMEAGMFRAVVVE
>CP020645.1|AWP61241.1|4809642_4810578_-|copper-resistance-protein-B
MAASLGLAAAAASAWAQAPAMDHGSMPGMNHGAAPAPAMDHGSMPGMDHGAPSAPAMDHGSMPGMDHGAAPAPAPAIGALPSSDGAGDQSYAAYGIHSHMMDDMVTSQLLFDKLGMTYDRDRRTGLQWDGQFWVGRDLDKLWIKSEGERVGGRSDGKVEAFWNRTISPFWDLQVGARRDFGTGPKRNWGAIGLQGVAPYNIETEVTAYVGGSGRTALALKAEYDLLLTQRLVLTPEIEASVYGKDDKARGIGAGLSDASFSLRLRYEITREVAPYVGVSFGRKFGKTASYASEEGESRSERAIMAGVRIWF
>CP020645.1|AWP60653.1|4808901_4809636_+|enoyl-CoA-hydratase
MSAMSASLPLAITRQPAAWTFTLSRPEKRNALSAELVEALIDGVDAAHREQVPLLVFAGAGRNFSAGFDFTDYETQSEGDLLLRMVRIEMLLQRVAGSPSLTLALAHGRNFGAGVDLFAACKWRYCTPEAGFRMPGLKFGLVLGTRRFRDIVGADQALSILGSARAFDADEARRIGFVRDCAAQAQWPALIDAAAEAATALDPATRATLHRVLRDDHDDADLAALARSAAQPGFKARIRDYLAQ
>CP020645.1|AWP60652.1|4807744_4808905_+|CoA-transferase
MNQESTLAGVRVIEICNVAAGPFCGMLLADMGADVVKIEPPGTGDTLRSWAPITDGYSENFASLNRNKRSVTLNLKNEAERDAAIELIAGADVLIENNRPGVMDRLGLGQQAMRARNPRLVYCSVSAYGQSGPRSQEGGFDLTLQAMSGLMSVTGEEGGAPVKCGVPVCDFTAGLYAAFAIAAALRRVQADGQGTHIDVSMLGATLGIAALQTSQYFGTGVDPVKLGSAHPRNAPYQVFRCKNGYFGMAAGNNSLWKAVCKVVERDDLHADPRFANPTDRAEHQVALRDILEAIFAEHDSHAWLERFRQAGVPCAPINDYSEVLADPQVEHMDWVQDLELPNGVRTRTFVSPVRFDARTAGVMRRPPALGEHNDEILSALAARPAG
>CP020645.1|AWP60651.1|4806933_4807728_+|IclR-family-transcriptional-regulator
MRCKGIRHMDKTLLKGLTVLEAISRLDGATPTLDQIAEEIGLTRSNTHRTLQTLAHAGYVRRDPATGSYQCTLKLFELGARQLASLDARKLAPPFMGELARLTNETVHLSVLDGLDVVYVDKLDSPQPLLAYSTVGGRAPAYAVATGKALLACQTADYLDHYGAAIKRHTEDTHVSLLALKQELADVNRIGYAINRGEWRQGIGGIAAPIFNGLDKAVAALGISGPLERLTNQKMREYAPLVQQAARQLSAHMGYRGGYFGGAA
>CP020645.1|AWP60650.1|4806053_4806644_-|cysteine-dioxygenase
MSERLLNTVVALGQLVERTGLQEAAILAQARQLIAGLVAHDDWLPDEMAQPHPEYYRQYLLYGDPRDRYSLVSFVWGPGQKTPVHDHTVWGVIGMLRGAETDQPFRRAADGRLAPEGPGKVLRPGDVACVSPSIGDIHQVSNAYDDRVSISIHLYGGNIGRIRRSVYDPQTGASKAFVSGYSNAMTPNLWAAPNAG
>CP020645.1|AWP60649.1|4804691_4806020_+|amidase
MLTIAALASAYRTRQTTPSATLRDLLDRIAVSPLNSFISVDPETVMRQAADADAAFAGGAPAGALHGIPVAVKDLIDVAGMRTTMGSQQYANQASAERDAQVVARLRAEGAIIVGKTNTHEFAYGPTGDRSYFGAACNPRDPARMTGGSSSGSAAALGAGLCAAALGTDTSASIRLPAALCGVVGLKPTYDLLPRAGAFDLSQTLDHVGPMSATVRDNAVLLDALAGQPAHSYARLAGQSVRGRTVGLATGFYLDYLDAPVRQALEQAQEAFRQAGAQVVPIEIAQVQAIYEAQQLVLKTEAYARHLRALTTDAPYQDEVRARLLTGADVLAVDYLQAMAMRTVARRAFDEALAQVDVLLCPTCGLTAPLRDQRTTALDGQEYSTTWLLTRLTAPTNLSGHPSLSVPFGADSQGLPISMQLIGRHLDEAVLYQFGQALEDAA
>CP020645.1|AWP60648.1|4803471_4804617_+|transporter
MIAFAPRTLAVASIAATVALAGCGQKEEQAAAGATPLRIGIIESVTGPAASYGDAHNKGTRLAVEEINKAGGFNGVPLEVHGEDDKSDPATGINAAKKLITQRKVDAIVGSAASLVTIAFSKENEKYKVPLVNGMAGSPTITEQGFQYTWRIKITDNQLDTKAIEHYVQNKNARKVAFLAENSDYGKPPTKAAADRARELGAEVVAYEEYNRGETDFKAQLTNIRDRAPDVLFVHGYYTEGSIIARQIRELGLKTQLIVNEGQGVPKFQELAGAAAEGAVFPTTWLPGLSDARSKQFETAYQARYNSLPGAFDAGSYEAVYTVVEAARKGGGTKPEQIQAGLAQLQGFETLLGPVRFDKKNQNDGSIRLARFNNGKIEPLQ
>CP020645.1|AWP60657.1|4814729_4816244_-|3-hydroxyacyl-CoA-dehydrogenase
MSEIQTIGIVGAGAMGRGIAQIAAQAGVLVRLYDTNAAAVEAARDALRQTWDKLAQKGKLSEADAQAALARIAPAAALADLADCQLVIEAVIERLDVKRDLFAALEEIVAADCVLASNTSSLSITAIAAACKRPQRVVGYHFFNPVPLMKVVEVIDGLRSDPAVGDALAELARRMGHTPVRAKDMPGFIVNHAGRGMNTEGLRVAQEAVAPFDQIDAIMREQAGFRMGPFELLDLTALDVSHPVMESIYRQFFDEPRFRPSPITTVRLAGGLIGRKAGEGFYAYPDGQKQVPAEPAAPALRAGLRAWVSPAHPDGHARASALLRGMAVELAEGATPPQDALIIVTPYGEDVSTCVQGQGLDGARTVGLDTLYAFEAGRRRTLMVSPATASNWRDDAHALVASDGAPVSVIEDSPGFVAQRIVACIVNIASDIAQQRIATPQDIDRAVTLGLGYPVGPLALGDKLGGARLLEILHNMQRVTGDPRYRPSLWLQRRVQLGLSLLHG
>CP020645.1|AWP60658.1|4816327_4817557_-|CoA-transferase
MSQRPAPLTGIRVLDLTRVLAGPWCTQNLADLGAEVIKIERPGAGDDTRAWGPPYLKDAAGNDTTEAAYYLSANRNKLSVALDIATPRGAELVRELAQQCDILVENFKVGGLRKYGLDYESVKAINPRLIYCSITGFGQTGPYASRPGYDFMIQGMGGLMSITGERDDLPGGGPQKAGVAVTDLMTGMYSTVGILAALHERNRSGLGQHIDMALLDCQVAMLANQNLNYMTSGKAPRRAGNAHQNLVPYQVFAVSDGHLIVAVGNDSQFRNYCRVIDLPELADDPRFATNPQRVQNRDELVPLLAERMATGERDAWLAALESAGVPAGPINTLDQVFEDPQVVARQIRRELPHPSAGTVPTASSPLRFSDSPVEYRRAPPLLGEHTRQVLSERLGLSETEIQALAAGQG
>CP020645.1|AWP60659.1|4817669_4818818_-|acyl-CoA-dehydrogenase
MALDNETLNLLLDAVRRFVNDRLVPAENELAETGRIPDEIVQEMRDLGLFGLSIAADYGGLGLTMEEEVRVVFELGQTSPAFRSLAGTNIGIGSQSIVLAGTDDQRQRYLPKLASGELIGSFALTEPDAGSDAMALRTSAVRDGDHYVLNGTKRFITNAPVAGLFSVMARTAPERRADSISCFLVEAGTPGVTLGKPDKKMGQAGALTCDVVFDNCRVPAEALLGGKEGTGFRTSMRVLDKGRLHIAALCVGIAERLVRDAVRYALERKQFGQPIAEFQLVQAMIADSQTELYAARSMVLDAARKRDLGQNVTMEAACSKLYATEMVGRVADRAVQIHGGAGYISEYAVERFYRDVRLFRIFEGTSQIQQLVIARETLKAYA
>CP020645.1|AWP60660.1|4818862_4819525_-|TetR-family-transcriptional-regulator
MQAGARLARQDNAMADAPAPAPKRARAGRPPTLAAPRERILEEAARLFARSGYENSSVADLAAAIGVSKAALYHYFPTKQDIYDAIILETLAGLLQAVTREVERQHEACERLRAFMVGHARYFARHHEQFVTMLIGYSGMALPERADAAQLRDRYEQLLRDLLEQGMAAGTLRRLDVAATGRAVLSMLNWMVRWYKPGQGDSAEQIADGYYDLLFNGLRI
>CP020645.1|AWP60661.1|4819638_4820631_+|nitronate-monooxygenase
MNARDTAMPHPVVAELYASMTLPVVCSPMFIVSNPKLAIAQCVSGVMGSFPALNARPQSLLGDWLDEVEAGLAEHRRAHPDGIVAPYAVNQIIHQSNDRLEHDLDVCARHRVPYIITSLRAPGDLVAGVHAWGGKVFHDVTTVRHAEKALEAGVDGLILVCAGAGGHAGTLSPFALVSEVRRFYDGPLVLSGAITSGQGILAALAMGADFAYMGTRFIATAEANASEAYKQAIVDASASDVLYTPFFTGIPGNYLKASIVAAGLDPADLPAAEAASSNFGTTRAKPWKDIWGAGQGVGGIASVLPARELVASLRAEYAQAQARLGARNLG
>CP020645.1|AWP60662.1|4820627_4821365_+|enoyl-CoA-hydratase
MNSLLTERDAAVLTLTINRPERRNALDTATYDALAAQLRAADADTGLAAVILTGAGDHFTAGNDLRDFQAERPAGDSPALRFLRALVDTDVPVLAAVEGHAVGVGVTLLQHCDFAFAAGTARLRMPFVALGLCPEGASSLLLPRLAGMRKAAEWLLQGRAFDAAEAHAAGLLTGVTEPGQALAAARAVAADLAAQPRQALRVSKRMLRQADRAAIHATLDHEAEQFRERLRSPEAQQAFARFFNK
>CP020645.1|AWP60663.1|4821444_4822266_-|enoyl-CoA-hydratase
MSETDTNPEHYARYRALRIRRHPEGILELVMGAKDASGKLSTADERLHRELADVWRDIDTDDQTRVVVIRGEGNGFSGGGDLGLVQQMAEDFEVRTRVWREARDLVYNIINCNKPIVSAMHGAAVGAGLVAGLLADISIAARDARIIDGHTRLGVAAGDHAAIVWPLLCGMAKAKYYLLLCDAVSGEEAERIGLVSLCVDRAELLSKAFEVAGRLAAGSQTAIRWTKYALNNWLRMAGPSFDTSLALEFMGFGGPDVHEGIKSLREKRAPDFR
>CP020645.1|AWP60664.1|4822354_4823215_+|NAD(P)H-hydrate-dehydratase
MDTSSSSLPAIERQHLPALFAARPTDAHKGSCGTLGVIGGGPGMVGAALLAARAGLKVGAGKVLVGLVAETPPLPCDPMQPELMLRDFRGLLEAGLGIDAWTAGCGCGMDALAANALSELFQLRGDAALVLDADGLNLLAAGAVQPRWGDAPVVLTPHPAEAGRLLGLSTEAVQADRPAAARTLAARYGAWVVLKGAGSIVCDPAGVCRINRTGNPGLATAGTGDVLAGILGALLAQRIAPEQAVPGAVWLHGAAADALVTHGIGPIGLTAGELADSARRLRNSRA
>CP020645.1|AWP60665.1|4823342_4823579_+|hypothetical-protein
MSDLTLSHNARLTDSLERELLRGAMEDQSNTIRPLAAVKAAAAGVGRGVRAVFAFIDEVNESMNRARAQSAHYTGSQW
>CP020645.1|AWP60666.1|4823875_4825504_+|transporter
MKLRTTLALLATSAGLAAAPGSASAQSLKIALSSEPTSADPHYHKQTQNDAFSAHVYSSLIGRDADMKLVPALATSWKNLDDLTWEFKLRDDVKFSNGKPFTSEDVLFTICRTLNNETNVSQSYMDTTKRIADVQTPDAHTVIIKTAAPLPLLPAELARSLPIVWNGIVEHGKLTFNPKEGCGVTGPWPTVADFNNGKDAIGTGPYKLKSYVKGTGIELERNDNYWGPKPYWKDVKMVPVPNAGPRLTGLLSGDFDVIENPAARDLPRIKSNPQFGFVATPSTRLIFFQPDVGRNPSPLVKSADGKNPLQDLRVRQAISMAIDRKTIVTRLMDGIATPAYQYMPDGMFGGVPNAPEIKYDPEGAKKLLAEAGYANGFELTISTPNDRYVNDGQIAQAVAQYLSRVGIKANVDAMTASLYFPKRAKREFSFSMGGWPAEVGEASALFQLWVASLDSPRSLGTSNYGGFSNAEFDKVFTEALVTVDVAKREKLLQQSTQIALDNVPLIPLHFESSIWAFRKGLTYEGRRDQFTLAMSVKPADQK

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Crispr_ID: CP020645_16

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP020645_16

4938791-4938903

Orphan

Consensus_repeat	Method
GTGCCTGTCCCCGCGGGGACAGGCACACCGCCGTGACGGCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP020645_16

>merge|CP020645|16|4938791-4938903|CRISPRCasFinder
GTGCCTGTCCCCGCGGGGACAGGCACACCGCCGTGACGGCCACGACGGTATCCGCCCCGGCGGGAATCCCGGTGCCTGTCCCCGCGGGGACAGGCACACTGCCGTGACGGCCA

>CP020645|16|16|4938791-4938903|CRISPRCasFinder
GTGCCTGTCCCCGCGGGGACAGGCACACCGCCGTGACGGCCA	CGACGGTATCCGCCCCGGCGGGAATCCCG
GTGCCTGTCCCCGCGGGGACAGGCACACTGCCGTGACGGCCA

Protein	Signature genes	Signature genes Name	Protein_function
CP020645.1\|AWP60775.1\|4944002_4945151_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
CP020645.1\|AWP60774.1\|4942762_4943755_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270296
CP020645.1\|AWP60769.1\|4936616_4937591_-\|alpha-ketoacid-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
CP020645.1\|AWP60765.1\|4931793_4933287_-\|acyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|102207
CP020645.1\|AWP60773.1\|4940628_4942761_-\|pimeloyl-CoA-synthetase	unknown	unknown	gnl\|CDD\|131764
CP020645.1\|AWP60768.1\|4935816_4936602_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|223955
CP020645.1\|AWP60766.1\|4933366_4934542_-\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
CP020645.1\|AWP60771.1\|4938993_4939779_-\|IclR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
CP020645.1\|AWP60761.1\|4926318_4928142_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|213186
CP020645.1\|AWP60763.1\|4929092_4930301_-\|amino-acid-binding-protein	unknown	unknown	gnl\|CDD\|380558
CP020645.1\|AWP60776.1\|4945147_4945954_+\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|223955
CP020645.1\|AWP60767.1\|4934547_4935813_-\|dihydrolipoamide-acyltransferase	unknown	unknown	gnl\|CDD\|237001
CP020645.1\|AWP60770.1\|4937592_4938564_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238958
CP020645.1\|AWP60777.1\|4945950_4947105_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238425
CP020645.1\|AWP60780.1\|4947896_4948289_+\|acyl-dehydratase	unknown	unknown	gnl\|CDD\|239525
CP020645.1\|AWP60764.1\|4930375_4931773_-\|MmgE/PrpD-family-protein-4	unknown	unknown	gnl\|CDD\|377179
CP020645.1\|AWP60762.1\|4928138_4929023_-\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|119324
CP020645.1\|AWP60778.1\|4947106_4947508_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224462
CP020645.1\|AWP60772.1\|4939855_4940632_-\|enoyl-CoA-hydratase	unknown	unknown	gnl\|CDD\|119339
CP020645.1\|AWP60779.1\|4947504_4947900_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP020645.1\|AWP60775.1\|4944002_4945151_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	2.8877e-124
CP020645.1\|AWP60774.1\|4942762_4943755_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	1.50499e-139
CP020645.1\|AWP60769.1\|4936616_4937591_-\|alpha-ketoacid-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	1.77452e-169
CP020645.1\|AWP60765.1\|4931793_4933287_-\|acyl-CoA-synthetase	gnl\|CDD\|102207	PRK06145, PRK06145, acyl-CoA synthetase; Validated.	0
CP020645.1\|AWP60773.1\|4940628_4942761_-\|pimeloyl-CoA-synthetase	gnl\|CDD\|131764	TIGR02717, Uncharacterized_protein_MJ0590, acetyl coenzyme A synthetase (ADP forming), alpha domain. Although technically reversible, it is believed that this group of ADP-dependent acetyl-CoA synthetases (ACS) act in the direction of acetate and ATP production in the organisms in which it has been characterized. In most species this protein exists as a fused alpha-beta domain polypeptide. In Pyrococcus and related species, however the domains exist as separate polypeptides. This model represents the alpha (N-terminal) domain. In Pyrococcus and related species there appears to have been the development of a paralogous family such that four other proteins are close relatives. In reference, one of these (along with its beta-domain partner) was characterized as ACS-II showing specificity for phenylacetyl-CoA. This model has been constructed to exclude these non-ACS-I paralogs. This may result in new, authentic ACS-I sequences falling below the trusted cutoff.	4.19245e-115
CP020645.1\|AWP60768.1\|4935816_4936602_-\|enoyl-CoA-hydratase	gnl\|CDD\|223955	COG1024, CaiD, Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism].	4.86287e-76
CP020645.1\|AWP60766.1\|4933366_4934542_-\|acyl-CoA-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	7.67701e-96
CP020645.1\|AWP60771.1\|4938993_4939779_-\|IclR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	1.44092e-47
CP020645.1\|AWP60761.1\|4926318_4928142_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	4.25038e-96
CP020645.1\|AWP60763.1\|4929092_4930301_-\|amino-acid-binding-protein	gnl\|CDD\|380558	cd06335, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. Members of this group are sequence-similar to members of the family of ABC-type hydrophobic amino acid transporters, such as leucine-isoleucine-valine binding protein (LIVBP); however their ligand specificity has not been determined experimentally.	6.9406e-136
CP020645.1\|AWP60776.1\|4945147_4945954_+\|enoyl-CoA-hydratase	gnl\|CDD\|223955	COG1024, CaiD, Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism].	2.06389e-73
CP020645.1\|AWP60767.1\|4934547_4935813_-\|dihydrolipoamide-acyltransferase	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	6.69292e-133
CP020645.1\|AWP60770.1\|4937592_4938564_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|238958	cd02000, TPP_E1_PDC_ADC_BCADC, Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex (BCADC). PDC catalyzes the irreversible oxidative decarboxylation of pyruvate to produce acetyl-CoA in the bridging step between glycolysis and the citric acid cycle. ADC participates in the breakdown of acetoin while BCADC participates in the breakdown of branched chain amino acids. BCADC catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine).	2.48882e-127
CP020645.1\|AWP60777.1\|4945950_4947105_+\|hypothetical-protein	gnl\|CDD\|238425	cd00829, SCP-x_thiolase, Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-Coa thiolase specific for branched-chain acyl CoAs, which is proteolytically cleaved from the sterol carrier protein.	4.50908e-123
CP020645.1\|AWP60764.1\|4930375_4931773_-\|MmgE/PrpD-family-protein-4	gnl\|CDD\|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	1.77503e-65
CP020645.1\|AWP60762.1\|4928138_4929023_-\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	3.70951e-58
CP020645.1\|AWP60778.1\|4947106_4947508_+\|hypothetical-protein	gnl\|CDD\|224462	COG1545, COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only].	6.80556e-24
CP020645.1\|AWP60772.1\|4939855_4940632_-\|enoyl-CoA-hydratase	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	1.72923e-33
CP020645.1\|AWP60780.1\|4947896_4948289_+\|acyl-dehydratase	gnl\|CDD\|239525	cd03441, R_hydratase_like, (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel beta-sheet wrapped around a central alpha helix, referred to as a hot dog fold. The active site lies within a substrate-binding tunnel formed by the homodimer. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and the fatty acid synthase beta subunit.	3.21769e-21

>CP020645.1|AWP60770.1|4937592_4938564_-|ABC-transporter-substrate-binding-protein
MARANKEQLLDAYQRMLGIRLVELRLGRLFADGEVPGFIHLSVGQEAVAAAMGMVLRPDDTVASTHRGHGHALAKGIDMDDFFLELMAREEGICKGRGGSMHVANMSIGMLGANAIVGASIPIALGSALAHQVRKTDALAVAFFGDGAMAEGVLHESLNLAALWQLPLLFLCENNGWAEFSPTHKQFVAPLDKLSAAFSIPHAKVDGNDVLAVMDAAQAAVADIRAGKGPRVLECITHRWRGHYEGDPQKYRDSDEISGLDEHDPVARFEAVLDSKGVSQAQRQKVRDAVQAQVDQAVERARKGRPPVWETARTDVYTQAEAR
>CP020645.1|AWP60769.1|4936616_4937591_-|alpha-ketoacid-dehydrogenase-subunit-beta
MAELRFAHAINRALAECMEEDPMVFLFGEDIAEAGGPFGVTRGLHDRFGSDRIRDTPISEATMANAAVGAALSGLKPVLEIMFMDFMTLTMDALVNQAAKARFMFGGQASVPMVVRTPHGGGISAGPQHSQCLEAWFAHIPGLKVVCPSNPADAYGLLKSAIRDPDPVVFVENKALYAAKGEVPDDAGPIPLGQARIARAGRDLTVVSYGAMVHKVERAAEALARDGIEAEVLDLRSIQPWDEAAVLASLRRTHRLLIVHEAVEAFGVGAEIAARMADIGFDELDAPIVRVAAPFVPVPFAPSLEAQYQPQEADIIAAARKLCA
>CP020645.1|AWP60768.1|4935816_4936602_-|enoyl-CoA-hydratase
MSEQSILTEVRDHVGIITINRPKLHNALDTPTLLELERALTTLEADAECRVIVVTGAGEKSFVAGGDLVDLNSRQGLAHYQEFAEDIHRVFRRFETSDKPTIAAVNGWALGGGTELLLCLDLRIVADNAAIALTEVNLGLFPGAGGTQRIIRQISPCQAKEMMFTGGRISAADAVRIGLANRAVPAADLMAETLALAGQIAAKSPLVLKLLKRTLRDGADMPLANALAHEQAMIGLVLDTRDAHEGIGAFLEKRAARFTGQ
>CP020645.1|AWP60767.1|4934547_4935813_-|dihydrolipoamide-acyltransferase
MSQLNDLLMPKLGLTMTEGMLIEWSVTSGAEVKAGDSLFVVETDKVANEIVAQADGTLAEILVAAGETVPVGTVVARWTGPGQGADDMADAPPAPAPAAQPAAEAAEAAPAVARQPARGGRVVATPLARRLAREAGLDLAQVSGSGPGGRIKAADVRQAPRAPEAAPAVSPDTAAPAPAARAPLAPAAGEQRIEASALVQSMARRMTQAKQVPHFYLSAEAEVSALLALRQRLNAQADAPRLTLNHFVIAAVARALAAMPHQNRIWNDDHIVQFQGIDVGVAVSTERGLMAPVLHGLDHASLDDIAAQSDALLGRVRAGKATREDMSGGAISISNAGMFNVTYMAPIINPPQSAILGVGSIRELFRPDEQGAPALRREMGLVLAADHRLHDGASALAFLNHVIDLLQDPYRLLRNRPHTKG
>CP020645.1|AWP60766.1|4933366_4934542_-|acyl-CoA-dehydrogenase
MDFSLSDEQKLIVETARRIGEDYGVDYWHDLDRRKAFPQECWQAICDAGLAGAALPQEHGGSGLGMLDLALIVEELSAGGGGATLGQLFMINPIFGGVPISKFGSEQMKRELLPALVGGKMNFCMALTEPDAGTNTLAMKSYAEAEPGGGWRLNGRKIWITAVDAAQKMLVVARTSRQTEGARPSDGISMFIIDVEREGLSYSAIDKVGTQTLSACSVFFDNVRIEPHELVGTLDKGFRELLDVLNTERIVTTASLIGAGRLAKRLAVQYANDRKVFGGKPISSYQGLQFPLAQSHAELQCARLMNLKAAALCDQGLPYGTEANIAKLIGSQAASHAIERSMQTMGGMGYAREFHVERLWRDARLFKFAPVSEEMILNYIAIHDLGMPKSY
>CP020645.1|AWP60765.1|4931793_4933287_-|acyl-CoA-synthetase
MFNLSASIAFHARRTPDKAAIVYRDQEIGYAEFHQRILQAAAMLHARGIGQNDVVALFMKNSAAFLELAFAASYLGAVFLPVNYRLAAPEAAYILGDAGAKLLLVDEEFDAIVALETPKIVIDAQAQADSRRLGQPGLEIPPQAAVAETDLVRLMYTSGTTSRPKGVMHSYGNLHWKSIDHVIALGLTASEKLLVVGPLYHVGAFDLPGIAVLWVGGTLCVHREFDPEAVLASIERHRLTCGWMAPVMLSRVLTVPDPDRFDLDTFAWCIAGGEKTPESRIRDFTRVFTRGRFVDGFGMTETCSGDTLMEAGREIEKIGSTGRALPHVEIRIADGAGGWLPANQKGEICMRGPKVTKGYWNAPEKTAEAFYGDWLRSGDVGYLDEEGFLFVTDRTKDMILTGAENVASSEVEAALYELPQIAEAAVIGVHDDKWGERITAVVVLNPGQTLTLEEIDRHCRQRLASFKVPRELKVVAELPRNPSGKVLKRVLRDEYNG
>CP020645.1|AWP60764.1|4930375_4931773_-|MmgE/PrpD-family-protein-4
MPPHRTHRTRRHPMTLAQRFARFAANLELDTIPAPALDKARACVLNGYGIALGSHPTPFFGVAERAVLAMDGEREDGATLLGSGRRSTVAGAALANAALFHGRAQEDTCGVAHFGAILLPLLTALVERGEGRIEDFLPALVAGYEVGGALEAAYSPLTTAAGLRASPLYGTVAAAAAAARLWRLPEDRTAAALANAASFAGGILQSFGDGTDEWRYQVGMAGRNGLAAATLAASGSVSAAGAFEGRSGFVRAFVRTECDVDAIAGQLGKDWSILKVTFKPYPVCALNQTPVRASLALREQLGAQADAVRAVRIHLNPTVVGYAGMDKEGPFESVSGTLMSIQFCVATTLLHGAPTIAHMTAFDDAGVLGLIPRIRPLADPALGLLSCRIEADVDGRAEPVVVQMHTDHTEYSYDRAGVSALVRRIGAETGVAPSAYDHIEKFAQALPHADLGDVLAAFGTIQTAR
>CP020645.1|AWP60763.1|4929092_4930301_-|amino-acid-binding-protein
MSWYRKSTTCLAVAAAMLASGAALAADTIKIGMTSALTGPYNEFGEGNRRAVELAVEQWNAKGGINGKKIEIAMLLDDQLNPDRAVQNIRAILDNKDIVGIIGPAGSGPTLAVIDMVQADGRPYMNPIAQTPVVTYPGEKTGEKPRPNVFSFALQNDIEAVAMGEYLAKKFKRVGIIHESTAYGVTGVDYLAASIAKNGGAKPVATDSYNQGAQDMTAQVARMKRANVDAIAAIGLGKDLAVLRRTMARLNVNVPLVASNGALGQPYQEGAGELTLGTLGTMIGAFGNPMRAPAADFAKAYKAKYGTDRWWGNDPENPQLFMAISVSNGYDAANILFEGIRLANSTDPKAVIAAIESIKDYQGVNTAYTFSKERHHGIETDGVKVFEYVKKGDKIRLEPIAQ
>CP020645.1|AWP60762.1|4928138_4929023_-|branched-chain-amino-acid-ABC-transporter-permease
MDFFIQMIVSGLSVGAVYALIGLGLNLTFWTTRVLNFGQGSVLMAGAMLTAVMVGAGVNVFLAVGVSLLVTAFILWIVELVGVRPMRRMSGSMGWVVSTLGIGIFLQGMASWLFGTQAVAFPDVLFSSADTVEFMGAYISLQYIAVFVISVMIVCLMELFLRHSIWGYGVRAVAHDRDLAALMGIPVYRVVVFSFLVSGVLAGIAGILVSQVSGTVDPNFGLHLLILAFVAAVVGGMGSAFGSLVGGLILGIMEKLVGGYVSPAAAEVVAFVLLIGVLTIRPQGLFGKRETVKV
>CP020645.1|AWP60761.1|4926318_4928142_-|branched-chain-amino-acid-ABC-transporter-permease
MRPMKLLGQLLTNSWTLGVLAIALAVGAGHADTGTVQMWSFVIINILLAQGINLLTGINGQISLGQAGFFAIGAYVSAIALKSWGVPFPVALAMATIVASGVGFLLAGPAGRVREFYLAMMSLGFGLIVYELARELRGVTGGVMGMRGIPSSQIGTLQIFGWSIDTVAYFRILLAVLLVVMLMLRNFVKSHYGRAFYAVHVSEIAAGSLGISQAAVKRAAYAISGGLAGLAGGFYAHMIGYLTPESFGLMRSIEILVMSIVGGLGSLAGQVYGAVLFTYLPQKLQAFNDYQYIVYGLILVFIFTLLPRGLAGLLGTQTRYSKYDQLRRAVAGQPAAPLGERPPHARRDAAQPLIRVEQVVMEFAGLRALAGVSLDLHAGSITALVGPNGSGKSTLVNVVSGIYRPTSGRVLYKGQDIAGWPSHKVAQAGITRTFQDPRNVPSFTVRENILMGAHRRYRHGALAAAVNTAGARREEAAFLRQVDALMQAAGLSEHADAIMSELPYGIQRLAEVARALASDPELLLLDEPAAGLSELESGHLIGLVRLARDHGVAVMVIDHHMDFLAELAEDVVVFEAGDEIYRGDMDGMRADPAVIQAYLGAEEPAHA
>CP020645.1|AWP60771.1|4938993_4939779_-|IclR-family-transcriptional-regulator
MAAEPPEKLVGALVGGLRVLRYLSAAPAGVGVTRVARDLQLNSSTCYNFLKTLVYEGLVTFDESTKTYSIALGLVELAKGVLEQGAYVRLIHPHLEEIARAHRVTATLWQRTSNERVVLVDRADNDSSVRVHMSVGQRLPMYIAALGRCMAANAGLDRDQLEQRFNALRWDDKPPFDEYLAGVQEARQNGYATDAGHYVKGVSTASAAVLDAFGKPVMAISAVGFSAQFTGDALEQLGEDLRERAGRITRALSGGRAGADS
>CP020645.1|AWP60772.1|4939855_4940632_-|enoyl-CoA-hydratase
MNAVANPVRVEDAGGVRAIVLDRAAKANALCAAMLDDIRHAIERAPRDGIDLLVLRSAAPTLFCAGGDIEEFALGAAALERQGAALRELMAAMARCPLPLLAVARGKAAGAGVILLAMTDLVIAAQDLSLACPEMAFSMYPVIVQAALETKISAARARQLCLSGQVLDAAAARDLGLVTDVLGLDGFDALAERRLAYYAGRRAALAIARKARLAMEPPDAAVARVRALEPLMHENFRIPGVQETIQHYLAGLRTRRAG
>CP020645.1|AWP60773.1|4940628_4942761_-|pimeloyl-CoA-synthetase
MTQDLDMAERSVAAPQWQGAARAAAVLEARSVAIVGASADPGKIAGRPLAYMLSRGFVGKLFPVNPTRAQVQGVKSYPSLAAIGEPVDLAIVGTPAALVEGVIREGIAAGVRAFVVFSSGFSETGEAGAALQRRLGELARAHGVAILGPNCLGVANSATGLIASFTTALEETPIRQGGFALVSQSGALGAYWMDICLRSGLGFSKWITTGNECDMDAAAAIAYLAGDADTRVIGLYVEDIRDTVAFRRALRAAAEAGKPVIAIKAGRSQAGAAAAASHTGALAGDDALYDACLRQHGALRVDSLGQMMDAARLYLFDSVPQGRRIAVMSVSGGAGVLIADEAERWGLALPPLAEHTASALAPVLPSFVQAANPLDLTGNVVQDTASIGRALEAVARDPGNDAIVLFVGLMHSIASAFTDAIAQARQRTHRPIIVIWIGAKEESVAALEQARIPVFRDIPPAVAAVGAAVRLQALREAALAMALPAAAPPAARAGRIEALAECDGKALLRELGAAGVPAGVLVAGPAPERLPAPLAYPVVAKLQAASLLHKSDIGGVVLGIASDQQLREAVQRLGDIAREHGIEARGVLVEPMQPFDHELLLGLRRDPRFGATLTLGRGGVEVELDADVASQLLPLSAGAIQAMLESLRAARLFKGFRGRGAVDLAALSSQIADLCRIFLEQPDLAEVEINPLAVRGDRAWVLDAVVSRYA
>CP020645.1|AWP60774.1|4942762_4943755_-|ABC-transporter-substrate-binding-protein
MNIGTSFPRISSRLAGALLAALAVAPVQAYAQQAYPSKPIEIIVASSAGGILDTIARTAAHGLERLGQSAVAKNLPGGGGTIATAALARMPGDGYTLGAVATSHAINPNIYNKLAYDTGRDFTNITQMVELTNFLVVNPSVPASNLKEFIALAKAKPGTLTYGSAGVGQSNHLSGELLQQDAGIKLVHVPYRGSAQALTDVIGGSVSAMFVDALSAEPYVKAGKLKLIAATGLARSPAYPDYPTLAESGLPGFNGNTWLGLVAPAGVPKDIVAKLQDAVRAEFEDPDVRKRLISQGVIPVASTPQAFSAFLDSEMKRWAEVIKVAGIEAN
>CP020645.1|AWP60775.1|4944002_4945151_+|acyl-CoA-dehydrogenase
MSLSFAFSSEHEAVRDTVRRLCQEELAPLVFEAEEQEAFPRRVFERWGELGLLGVRYPEADGGSGLDKVSDCIVREELSYLSQAFASTWSAHTHLGIWPIWKAGTPAQKARFLAPALAGRKVAGFGLSEPDGGSNVRAMKTRAERVEGGWRLHGSKLYITNAPFADFLLVAARTSAALKPESISLFIVELPNAGFDIAKLKKEGIRASETALIHIDNAFVPDDCLLGETEGTYPLILESLSENRVGVAANALGMARAAFDAAAGFANDRLVAGKRVGEYQAIAHKLADMSAQIEATRWLVYYGAWRVDQGTLDAATAARVKLVASETAVAVSEQAIRIFGGAGIMREYPVGRIHRDALVYVIGEGTSEIQKNIIARSLGFKP
>CP020645.1|AWP60776.1|4945147_4945954_+|enoyl-CoA-hydratase
MSDYVLRERRGATFVITLNRPERRNAFDLEVRQSLAEAIFEARDDDAVKAVIITGTQGVFCAGGDLKSLSDGKRPIYQDRDRIRRLHTWFHELVNLEKPVIAAVDGPAFGAGFNLALACDFILGTPAARFCAVFGRIGLVPDLGGFFLLPRIVGLQQAKELVFTAREVGADEARALGILYRVVPAPGLLDEALALAARFHSASTLALGMSKNILNRSFNLDQNTLAELESHAQALAIHSEYHEAAVARFLDKQPLPFSWPGEDKDGQS
>CP020645.1|AWP60777.1|4945950_4947105_+|hypothetical-protein
MSMNAFITGASDTSVGELPGSSCMGLHAEAAFGAIADAGLEPGDIDGVLCAYSFTEPHLMLGSVFCEYTGIHPGFCTAVQAGGASACIMIMQAAALVASGQCRHVLVVTGDNRLTGLSRDGAVAALAEVGHPQFERPFGISVPASYALVAQRYMHEYGATPEHLAAIAVEHRRHAGRHPKAHKRDPISIDDVLNSREISTPLRLLDCCLISDGGAALVISSRAASAASSKRSVEILGAGQGHTHEHIVAAPSLTDFGCKASSARAFAAAGVRPADIDVAQIYDSFTITLLVELESIGFFERGQAGPAALQGQLGLGGALPCNTHGGLLSYGHSGAAGGMFHAVEAVHQLRGQADQRQVDGARLAFVHGDGGILSAHCSLVLGAA
>CP020645.1|AWP60778.1|4947106_4947508_+|hypothetical-protein
MEKPPITPNAESLPFWQGCRDHRLRYQQCASCGTVQRIPRAVCTHCHGRALQWRDSAGQGVVLSHTTVRRAPTPAFKADTPYAIALVDLDEGFRLMVNVRGGADAPLAIGARVRIVFEARGDGAVPIAEMETP
>CP020645.1|AWP60779.1|4947504_4947900_+|hypothetical-protein
MTQLYTYETFTPGTVLGEWAEPLDARLVATWERLFGAEARDQPARQVGLTVALMIRAYLNVVTPRPPGNIHAQQILSIDGLPGVGETVRSRIRCLGKEIRRERRYLQLEVSGVGERERNLYTGRMNLIWAA
>CP020645.1|AWP60780.1|4947896_4948289_+|acyl-dehydratase
MRNTMTQRLEEVSMRVTQADIDIYAELTDDFNPLHVDPAFAATTPMGGTIAHGTLSVNLIWQSLARSLGAAALARIDLDIRFLKPLFAGGAITAGGQPDAAEPDRYEVWVKGADGATLIAGHARLAPITD

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP020645_15	15.1\|4814615\|37\|CP020645\|CRISPRCasFinder	4814615-4814651	37	CP020645.1	693139-693175	0	1.0
CP020645_5	5.1\|1423989\|53\|CP020645\|CRISPRCasFinder	1423989-1424041	53	CP020645.1	3152873-3152925	1	0.981
CP020645_15	15.1\|4814615\|37\|CP020645\|CRISPRCasFinder	4814615-4814651	37	CP020645.1	1566012-1566048	1	0.973
CP020645_15	15.1\|4814615\|37\|CP020645\|CRISPRCasFinder	4814615-4814651	37	CP020645.1	2548657-2548693	1	0.973
CP020645_5	5.1\|1423989\|53\|CP020645\|CRISPRCasFinder	1423989-1424041	53	CP020645.1	3383461-3383513	2	0.962
CP020645_5	5.1\|1423989\|53\|CP020645\|CRISPRCasFinder	1423989-1424041	53	CP020645.1	3859312-3859364	2	0.962
CP020645_15	15.1\|4814615\|37\|CP020645\|CRISPRCasFinder	4814615-4814651	37	CP020645.1	1496892-1496928	2	0.946

1. spacer 15.1|4814615|37|CP020645|CRISPRCasFinder matches to position: 693139-693175, mismatch: 0, identity: 1.0

gccgtacgccatcgacgcttgaccgccaagacggtat	CRISPR spacer
gccgtacgccatcgacgcttgaccgccaagacggtat	Protospacer
*************************************

2. spacer 5.1|1423989|53|CP020645|CRISPRCasFinder matches to position: 3152873-3152925, mismatch: 1, identity: 0.981

cgccgggccgccccaaggcaaaaaggccccctcggggggcagcaagcgcgcat	CRISPR spacer
cgccgggccgccccaaggcaaaaaggccccctcggggggcagcaagcccgcat	Protospacer
*********************************************** *****

3. spacer 15.1|4814615|37|CP020645|CRISPRCasFinder matches to position: 1566012-1566048, mismatch: 1, identity: 0.973

gccgtacgccatcgacgcttgaccgccaagacggtat	CRISPR spacer
gccgtacgccatcgacgcttggccgccaagacggtat	Protospacer
*********************.***************

4. spacer 15.1|4814615|37|CP020645|CRISPRCasFinder matches to position: 2548657-2548693, mismatch: 1, identity: 0.973

gccgtacgccatcgacgcttgaccgccaagacggtat	CRISPR spacer
gccgtacgccatcgacgcttgaccgccaagacggcat	Protospacer
**********************************.**

5. spacer 5.1|1423989|53|CP020645|CRISPRCasFinder matches to position: 3383461-3383513, mismatch: 2, identity: 0.962

cgccgggccgccccaaggcaaaaaggccccctcggggggcagcaagcgcgcat	CRISPR spacer
cgccgggccgccccaaggcaaaaaagccccctcggggggcagcaagcccgcat	Protospacer
************************.********************** *****

6. spacer 5.1|1423989|53|CP020645|CRISPRCasFinder matches to position: 3859312-3859364, mismatch: 2, identity: 0.962

cgccgggccgccccaaggcaaaaaggccccctcggggggcagcaagcgcgcat	CRISPR spacer
cgccgggccgccccaaggcaaaaaagccccctcggggggcagcaagcccgcat	Protospacer
************************.********************** *****

7. spacer 15.1|4814615|37|CP020645|CRISPRCasFinder matches to position: 1496892-1496928, mismatch: 2, identity: 0.946

gccgtacgccatcgacgcttgaccgccaagacggtat	CRISPR spacer
gccgtacgccatcgacgcttcgccgccaagacggtat	Protospacer
******************** .***************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP020645_11	11.1\|3929543\|25\|CP020645\|CRISPRCasFinder	3929543-3929567	25	NC_014818	Asticcacaulis excentricus CB 48 plasmid pASTEX01, complete sequence	156395-156419	3	0.88
CP020645_11	11.1\|3929543\|25\|CP020645\|CRISPRCasFinder	3929543-3929567	25	NZ_MN366357	Bacterium plasmid pALTS28, complete sequence	40540-40564	3	0.88
CP020645_11	11.1\|3929543\|25\|CP020645\|CRISPRCasFinder	3929543-3929567	25	NZ_CP020047	Thiomonas intermedia strain ATCC 15466 plasmid pXI1, complete sequence	37294-37318	3	0.88
CP020645_11	11.1\|3929543\|25\|CP020645\|CRISPRCasFinder	3929543-3929567	25	KJ850907	Uncultured bacterium plasmid pSFA231, complete sequence	39749-39773	3	0.88
CP020645_11	11.1\|3929543\|25\|CP020645\|CRISPRCasFinder	3929543-3929567	25	MF495477	Aeromonas salmonicida plasmid pS28-3, complete sequence	3303-3327	3	0.88
CP020645_11	11.1\|3929543\|25\|CP020645\|CRISPRCasFinder	3929543-3929567	25	AJ297913	Uncultured bacterium plasmid pIPO2T, complete sequence	3217-3241	3	0.88
CP020645_11	11.1\|3929543\|25\|CP020645\|CRISPRCasFinder	3929543-3929567	25	NC_010332	Collimonas fungivorans plasmid pTer331, complete sequence	3169-3193	3	0.88
CP020645_11	11.1\|3929543\|25\|CP020645\|CRISPRCasFinder	3929543-3929567	25	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	228786-228810	5	0.8
CP020645_16	16.1\|4938833\|29\|CP020645\|CRISPRCasFinder	4938833-4938861	29	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	116400-116428	5	0.828
CP020645_16	16.1\|4938833\|29\|CP020645\|CRISPRCasFinder	4938833-4938861	29	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1079050-1079078	5	0.828
CP020645_16	16.1\|4938833\|29\|CP020645\|CRISPRCasFinder	4938833-4938861	29	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	1896855-1896883	5	0.828
CP020645_16	16.1\|4938833\|29\|CP020645\|CRISPRCasFinder	4938833-4938861	29	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	269611-269639	5	0.828
CP020645_11	11.2\|3929597\|31\|CP020645\|CRISPRCasFinder	3929597-3929627	31	NZ_CP017427	Methylobacterium sp. XJLW plasmid unnamed1, complete sequence	72746-72776	7	0.774
CP020645_11	11.2\|3929597\|31\|CP020645\|CRISPRCasFinder	3929597-3929627	31	AP014019	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C106A-MedDCM-OCT-S39-C83, * SEQUENCING IN PROGRESS *	14936-14966	7	0.774
CP020645_11	11.2\|3929597\|31\|CP020645\|CRISPRCasFinder	3929597-3929627	31	AP014018	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C106A-MedDCM-OCT-S35-C77, * SEQUENCING IN PROGRESS *	17092-17122	7	0.774
CP020645_11	11.2\|3929597\|31\|CP020645\|CRISPRCasFinder	3929597-3929627	31	NZ_CP032685	Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence	717359-717389	7	0.774
CP020645_11	11.2\|3929597\|31\|CP020645\|CRISPRCasFinder	3929597-3929627	31	NZ_CP032690	Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence	716908-716938	7	0.774
CP020645_11	11.2\|3929597\|31\|CP020645\|CRISPRCasFinder	3929597-3929627	31	NZ_CP032342	Azospirillum brasilense strain MTCC4038 plasmid p3, complete sequence	184701-184731	8	0.742
CP020645_11	11.2\|3929597\|31\|CP020645\|CRISPRCasFinder	3929597-3929627	31	NZ_CP033321	Azospirillum brasilense strain Cd plasmid p3, complete sequence	618590-618620	8	0.742
CP020645_11	11.2\|3929597\|31\|CP020645\|CRISPRCasFinder	3929597-3929627	31	NZ_CP033315	Azospirillum brasilense strain Sp 7 plasmid p3, complete sequence	18926-18956	8	0.742
CP020645_11	11.2\|3929597\|31\|CP020645\|CRISPRCasFinder	3929597-3929627	31	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	5881058-5881088	8	0.742
CP020645_16	16.1\|4938833\|29\|CP020645\|CRISPRCasFinder	4938833-4938861	29	NZ_CP013109	Sinorhizobium americanum strain CFNEI 73 plasmid B, complete sequence	5614-5642	8	0.724
CP020645_16	16.1\|4938833\|29\|CP020645\|CRISPRCasFinder	4938833-4938861	29	NZ_CP040819	Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence	380390-380418	8	0.724
CP020645_16	16.1\|4938833\|29\|CP020645\|CRISPRCasFinder	4938833-4938861	29	NZ_CP013053	Sinorhizobium americanum CCGM7 plasmid B, complete sequence	5614-5642	8	0.724

1. spacer 11.1|3929543|25|CP020645|CRISPRCasFinder matches to NC_014818 (Asticcacaulis excentricus CB 48 plasmid pASTEX01, complete sequence) position: , mismatch: 3, identity: 0.88

ccagccggctgagccggcagcggcc	CRISPR spacer
tcagacggctgagccggcaccggcc	Protospacer
.*** ************** *****

2. spacer 11.1|3929543|25|CP020645|CRISPRCasFinder matches to NZ_MN366357 (Bacterium plasmid pALTS28, complete sequence) position: , mismatch: 3, identity: 0.88

ccagccggctgagccggcagcggcc	CRISPR spacer
cgagcaggccgagccggcagcggcc	Protospacer
* *** ***.***************

3. spacer 11.1|3929543|25|CP020645|CRISPRCasFinder matches to NZ_CP020047 (Thiomonas intermedia strain ATCC 15466 plasmid pXI1, complete sequence) position: , mismatch: 3, identity: 0.88

ccagccggctgagccggcagcggcc	CRISPR spacer
cgagcaggccgagccggcagcggcc	Protospacer
* *** ***.***************

4. spacer 11.1|3929543|25|CP020645|CRISPRCasFinder matches to KJ850907 (Uncultured bacterium plasmid pSFA231, complete sequence) position: , mismatch: 3, identity: 0.88

ccagccggctgagccggcagcggcc	CRISPR spacer
cgagcaggccgagccggcagcggcc	Protospacer
* *** ***.***************

5. spacer 11.1|3929543|25|CP020645|CRISPRCasFinder matches to MF495477 (Aeromonas salmonicida plasmid pS28-3, complete sequence) position: , mismatch: 3, identity: 0.88

ccagccggctgagccggcagcggcc	CRISPR spacer
cgagcaggccgagccggcagcggcc	Protospacer
* *** ***.***************

6. spacer 11.1|3929543|25|CP020645|CRISPRCasFinder matches to AJ297913 (Uncultured bacterium plasmid pIPO2T, complete sequence) position: , mismatch: 3, identity: 0.88

ccagccggctgagccggcagcggcc	CRISPR spacer
cgagcaggccgagccggcagcggcc	Protospacer
* *** ***.***************

7. spacer 11.1|3929543|25|CP020645|CRISPRCasFinder matches to NC_010332 (Collimonas fungivorans plasmid pTer331, complete sequence) position: , mismatch: 3, identity: 0.88

ccagccggctgagccggcagcggcc	CRISPR spacer
cgagcaggccgagccggcagcggcc	Protospacer
* *** ***.***************

8. spacer 11.1|3929543|25|CP020645|CRISPRCasFinder matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 5, identity: 0.8

ccagccggctgagccggcagcggcc	CRISPR spacer
gatgccggctgagccggctgcggct	Protospacer
   *************** *****.

9. spacer 16.1|4938833|29|CP020645|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 5, identity: 0.828

cgacggtatccgccccggcgggaatcccg	CRISPR spacer
cgacggtttccgccccggcgggggtcacc	Protospacer
******* **************..** *

10. spacer 16.1|4938833|29|CP020645|CRISPRCasFinder matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.828

cgacggtatccgccccggcgggaatcccg	CRISPR spacer
cgacggtttccgccccggcgggggtcacc	Protospacer
******* **************..** *

11. spacer 16.1|4938833|29|CP020645|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 5, identity: 0.828

cgacggtatccgccccggcgggaatcccg	CRISPR spacer
cgacggtttccgccccggcgggggtcacc	Protospacer
******* **************..** *

12. spacer 16.1|4938833|29|CP020645|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.828

cgacggtatccgccccggcgggaatcccg	CRISPR spacer
cgacggtttccgccccggcgggggtcacc	Protospacer
******* **************..** *

13. spacer 11.2|3929597|31|CP020645|CRISPRCasFinder matches to NZ_CP017427 (Methylobacterium sp. XJLW plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.774

ggctccggtggaaacggctccggcggaaacg	CRISPR spacer
cgctccggtggaaagggctcgggcggggtca	Protospacer
 ************* ***** *****.. *.

14. spacer 11.2|3929597|31|CP020645|CRISPRCasFinder matches to AP014019 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C106A-MedDCM-OCT-S39-C83, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.774

ggctccggtggaaacggctccggcggaaacg	CRISPR spacer
aaaactggtggaaacggcggcggcggaaacg	Protospacer
..  *.************  ***********

15. spacer 11.2|3929597|31|CP020645|CRISPRCasFinder matches to AP014018 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C106A-MedDCM-OCT-S35-C77, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.774

ggctccggtggaaacggctccggcggaaacg	CRISPR spacer
aaaactggtggaaacggcggcggcggaaacg	Protospacer
..  *.************  ***********

16. spacer 11.2|3929597|31|CP020645|CRISPRCasFinder matches to NZ_CP032685 (Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence) position: , mismatch: 7, identity: 0.774

ggctccggtggaaacggctccggcggaaacg	CRISPR spacer
ggctccggtggaaacagcaccggtgttttcg	Protospacer
***************.** ****.*    **

17. spacer 11.2|3929597|31|CP020645|CRISPRCasFinder matches to NZ_CP032690 (Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence) position: , mismatch: 7, identity: 0.774

ggctccggtggaaacggctccggcggaaacg	CRISPR spacer
ggctccggtggaaacagcaccggtgttttcg	Protospacer
***************.** ****.*    **

18. spacer 11.2|3929597|31|CP020645|CRISPRCasFinder matches to NZ_CP032342 (Azospirillum brasilense strain MTCC4038 plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.742

ggctccggtggaaacggctccggcggaaacg	CRISPR spacer
atctccggcggaagcggctccggcggcgcct	Protospacer
. ******.****.************ . *

19. spacer 11.2|3929597|31|CP020645|CRISPRCasFinder matches to NZ_CP033321 (Azospirillum brasilense strain Cd plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.742

ggctccggtggaaacggctccggcggaaacg	CRISPR spacer
atctccggcggaagcggctccggcggcgcct	Protospacer
. ******.****.************ . *

20. spacer 11.2|3929597|31|CP020645|CRISPRCasFinder matches to NZ_CP033315 (Azospirillum brasilense strain Sp 7 plasmid p3, complete sequence) position: , mismatch: 8, identity: 0.742

ggctccggtggaaacggctccggcggaaacg	CRISPR spacer
atctccggcggaagcggctccggcggcgcct	Protospacer
. ******.****.************ . *

21. spacer 11.2|3929597|31|CP020645|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 8, identity: 0.742

ggctccggtggaaacggctccggcggaaacg	CRISPR spacer
gattccggcggcaacggctccggcggccagt	Protospacer
*..*****.** **************  *

22. spacer 16.1|4938833|29|CP020645|CRISPRCasFinder matches to NZ_CP013109 (Sinorhizobium americanum strain CFNEI 73 plasmid B, complete sequence) position: , mismatch: 8, identity: 0.724

cgacggtatccgccccggcgggaatcccg	CRISPR spacer
atcagggatccgccccggcgggaagccga	Protospacer
    ** ***************** ** .

23. spacer 16.1|4938833|29|CP020645|CRISPRCasFinder matches to NZ_CP040819 (Paraoceanicella profunda strain D4M1 plasmid pD4M1A, complete sequence) position: , mismatch: 8, identity: 0.724

cgacggtatccgccccggcgggaatcccg	CRISPR spacer
tctcggcatccgccccggcgggaagcatc	Protospacer
.  ***.***************** * .

24. spacer 16.1|4938833|29|CP020645|CRISPRCasFinder matches to NZ_CP013053 (Sinorhizobium americanum CCGM7 plasmid B, complete sequence) position: , mismatch: 8, identity: 0.724

cgacggtatccgccccggcgggaatcccg	CRISPR spacer
atcagggatccgccccggcgggaagccga	Protospacer
    ** ***************** ** .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2296089 : 2303745

Moraxella_phage(33.33%)

tRNA

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AWP58456.1\|2296089_2296473_-	thiol reductase thioredoxin	V9SJ74	Achromobacter_phage	8.1e-09	25.8
AWP58457.1\|2296608_2297634_-	LLM class flavin-dependent oxidoreductase	NA	NA	NA	NA
AWP58458.1\|2297839_2299132_-	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	1.7e-66	36.0
AWP58459.1\|2299266_2300307_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	A0A0R6PI74	Moraxella_phage	9.3e-92	51.6
AWP58460.1\|2300550_2301198_-	glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
AWP58461.1\|2301323_2302082_+	5'/3'-nucleotidase SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	6.8e-68	50.8
AWP61150.1\|2302156_2302846_+	protein-L-isoaspartate O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	3.2e-32	46.9
AWP58462.1\|2302863_2303745_+	peptidase	A0A292GJG6	Xanthomonas_phage	4.6e-15	49.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP020645

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection