CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP036176	Klebsiella sp. WCHKl090001 plasmid p1_090001, complete sequence	0 crisprs	csa3	0	0	2	0
CP036175	Klebsiella sp. WCHKl090001 chromosome, complete genome	6 crisprs	cas14j,csa3,cas3,DEDDh,DinG,WYL,RT	2	3	4	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1480 : 63194

Bacillus_phage(23.53%)

protease,integrase,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBG11266.1\|1480_2266_-\|integrase	phage integrase family protein	I3WFA4	Macacine_betaherpesvirus	9.3e-52	86.8
QBG11375.1\|2317_2668_-	hypothetical protein	NA	NA	NA	NA
QBG11267.1\|2820_3759_-	hypothetical protein	NA	NA	NA	NA
QBG11268.1\|4322_4943_+	hypothetical protein	NA	NA	NA	NA
QBG11269.1\|4935_5817_+	hypothetical protein	NA	NA	NA	NA
QBG11270.1\|6078_9204_-	hypothetical protein	NA	NA	NA	NA
QBG11271.1\|9827_10736_+	HNH endonuclease	NA	NA	NA	NA
QBG11272.1\|11143_11494_-	DUF305 domain-containing protein	A0A218MND9	uncultured_virus	6.7e-18	52.4
QBG11273.1\|11639_12071_-	silver-binding protein SilE	NA	NA	NA	NA
QBG11274.1\|12316_13792_-	copper/silver sensor histidine kinase SilS	W8CYF6	Bacillus_phage	1.0e-27	30.1
QBG11275.1\|13784_14465_-	copper/silver response regulator transcription factor SilR	W8CYM9	Bacillus_phage	7.8e-31	35.6
QBG11276.1\|14466_14592_+	outer-membrane efflux lipo domain protein	NA	NA	NA	NA
QBG11277.1\|14654_16040_+	Cu(+)/Ag(+) efflux RND transporter outer membrane channel SilC	NA	NA	NA	NA
QBG11278.1\|16068_16422_+	copper ABC transporter substrate-binding protein	NA	NA	NA	NA
QBG11279.1\|16535_17828_+	Cu(+)/Ag(+) efflux RND transporter periplasmic adaptor subunit SilB	NA	NA	NA	NA
QBG11280.1\|17838_20985_+	Cu(+)/Ag(+) efflux RND transporter permease subunit SilA	S5VTK5	Leptospira_phage	8.0e-62	22.6
QBG11281.1\|21071_21512_+	hypothetical protein	NA	NA	NA	NA
QBG11282.1\|21638_24086_+	Ag(+)-translocating P-type ATPase SilP	A0A218MNH6	uncultured_virus	3.8e-83	35.6
QBG11283.1\|24126_24324_+	DUF2933 domain-containing protein	NA	NA	NA	NA
QBG11284.1\|24357_25095_-	peptidase M23	A0A2H4JAF5	uncultured_Caudovirales_phage	1.3e-10	31.9
QBG11285.1\|25383_25833_-	copper resistance protein	NA	NA	NA	NA
QBG11286.1\|26067_27885_+	multicopper oxidase PcoA	NA	NA	NA	NA
QBG11376.1\|27884_28781_+	copper resistance outer membrane transporter PcoB	NA	NA	NA	NA
QBG11287.1\|28820_29201_+	copper resistance system metallochaperone PcoC	NA	NA	NA	NA
QBG11288.1\|29205_30135_+	copper resistance inner membrane protein PcoD	NA	NA	NA	NA
QBG11289.1\|30189_30870_+	copper response regulator transcription factor PcoR	W8CYM9	Bacillus_phage	8.7e-30	34.4
QBG11290.1\|30866_32267_+	copper resistance membrane spanning protein PcoS	W8CYF6	Bacillus_phage	6.4e-19	26.9
QBG11291.1\|32482_32917_+	copper-binding protein	NA	NA	NA	NA
QBG11292.1\|33294_33414_-	type II toxin-antitoxin system RelE/ParE family toxin	NA	NA	NA	NA
QBG11293.1\|33379_33559_-	antitoxin	NA	NA	NA	NA
QBG11294.1\|33845_34427_+	hypothetical protein	NA	NA	NA	NA
QBG11295.1\|34582_35584_+\|protease	CAAX protease	NA	NA	NA	NA
QBG11377.1\|35722_36301_-	hypothetical protein	NA	NA	NA	NA
QBG11296.1\|36590_36854_+	hypothetical protein	NA	NA	NA	NA
QBG11297.1\|36850_37417_+	hypothetical protein	NA	NA	NA	NA
QBG11298.1\|37447_37942_+	DNA-binding protein	NA	NA	NA	NA
QBG11299.1\|37985_38354_+	hypothetical protein	NA	NA	NA	NA
QBG11300.1\|38384_38588_+	hemolysin expression modulator Hha	NA	NA	NA	NA
QBG11301.1\|38636_38894_+	hypothetical protein	NA	NA	NA	NA
QBG11302.1\|39110_40091_+\|transposase	IS5-like element ISKpn26 family transposase	A0A077SK28	Escherichia_phage	6.8e-185	98.8
QBG11378.1\|40214_40424_+	hypothetical protein	NA	NA	NA	NA
QBG11303.1\|40599_40866_+	DUF1778 domain-containing protein	NA	NA	NA	NA
QBG11304.1\|40853_41336_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
QBG11379.1\|41544_42891_+\|transposase	ISNCY family transposase	NA	NA	NA	NA
QBG11305.1\|42949_43741_+	tetratricopeptide repeat protein	NA	NA	NA	NA
QBG11306.1\|45318_45510_-	hypothetical protein	NA	NA	NA	NA
QBG11307.1\|46572_46980_-	Cd(II)/Pb(II)-responsive transcriptional regulator	NA	NA	NA	NA
QBG11308.1\|47075_47972_+	cation transporter	NA	NA	NA	NA
QBG11309.1\|47975_48488_+	signal peptidase II	NA	NA	NA	NA
QBG11310.1\|48509_49799_+\|transposase	ISL3-like element ISPpu12 family transposase	A0A2D1GQC1	Lysinibacillus_phage	9.5e-86	40.4
QBG11311.1\|50572_51754_+	glycosyl hydrolase family protein	A0A0B5JD41	Pandoravirus	1.6e-31	30.7
QBG11312.1\|51975_52581_-	DNA resolvase	A0A1S5Y2X8	uncultured_archaeal_virus	5.5e-20	35.3
QBG11313.1\|52675_55573_+\|transposase	Tn3-like element Tn5403 family transposase	A0A1B0V7H9	Salmonella_phage	4.2e-182	37.8
QBG11314.1\|58509_59088_+	recombinase family protein	A0A0F7LA37	Escherichia_phage	3.9e-23	37.7
QBG11315.1\|59263_60469_+	chromate efflux transporter	NA	NA	NA	NA
QBG11316.1\|60479_60785_+	PadR family transcriptional regulator	NA	NA	NA	NA
QBG11317.1\|61366_61792_+	arsenate reductase (glutaredoxin)	A0A2H4J8T1	uncultured_Caudovirales_phage	2.8e-50	71.4
QBG11318.1\|61920_63194_-\|transposase	IS3 family transposase	Q9ZXG3	Shigella_phage	1.0e-169	95.3

DBSCAN-SWA_2

95464 : 109970

Vibrio_phage(28.57%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBG11355.1\|95464_97462_-	BCCT family transporter	A0A2I7QNT1	Vibrio_phage	3.3e-21	25.9
QBG11356.1\|98838_99711_-	incFII family plasmid replication initiator RepA	NA	NA	NA	NA
QBG11383.1\|99703_99775_-	RepA leader peptide Tap	NA	NA	NA	NA
QBG11357.1\|100012_100261_-	replication regulatory protein RepA	NA	NA	NA	NA
QBG11358.1\|100442_103340_-\|transposase	Tn3-like element Tn5403 family transposase	A0A1B0V7H9	Salmonella_phage	4.2e-182	37.8
QBG11359.1\|103434_104040_+	DNA resolvase	A0A1S5Y2X8	uncultured_archaeal_virus	5.5e-20	35.3
QBG11360.1\|104175_104880_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
QBG11361.1\|105295_105721_+	arsenate reductase (glutaredoxin)	A0A2H4J8T1	uncultured_Caudovirales_phage	6.6e-52	72.1
QBG11362.1\|105863_106181_-	hypothetical protein	NA	NA	NA	NA
QBG11363.1\|106209_106461_-	DNA polymerase III subunit theta	Q71T70	Escherichia_phage	1.3e-15	57.0
QBG11364.1\|106639_106831_-	hypothetical protein	NA	NA	NA	NA
QBG11365.1\|106908_107334_-	antirestriction protein	NA	NA	NA	NA
QBG11366.1\|107768_108551_-	hypothetical protein	NA	NA	NA	NA
QBG11367.1\|108604_109024_-	DUF1380 domain-containing protein	NA	NA	NA	NA
QBG11368.1\|109068_109290_-	hypothetical protein	NA	NA	NA	NA
QBG11369.1\|109289_109970_-	DNA methylase	A0A2I7RE86	Vibrio_phage	1.8e-27	35.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. CP036175

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CRISPR-Cas detection and classification

Crispr_ID: CP036175_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP036175_1

729534-729973

Orphan

Consensus_repeat	Method
AGGTGATTAAAAGGGAAGATGAATGACTGTCCACGACGCTATACCGAAAAGAAAGCGGCTTAAC	PILER-CR

3 spacers

The CRISPR arrays of CP036175_1

>merge|CP036175|1|729534-729973|PILER-CR
AGGTGATTAAAAGGGAAGATGAATGACTGTCCACGACGCTATACTGAAAAGAAAGCGGCTTAACGGTCAGCTTCCTCATTCAACAAAACCCCGTCAGAAATGGCGGGGTTTTTGCTTTCTGGTACAGGTGAATAAAAAGGGAAGATGAATGACTGTCCACGACGCTATACCGAAAAGAAAGCGGCTTAACGGTCAGCTTCCTCATTCAACAAAACCCCGTCAGAAATGGCGGGGTTTTTGCTTTCTGGTACAGGTGATTAAAAGGGCAGATGAATGACTGTCCACGACGCTATACCGAAAAGAAAGCGGCTTAACGGTCAGCTTCAACTTTTCAGAAAACCCCGTCAGAAATGGCGGGGTTTTTGCTTTCTGGTACAGGTGATTAAAAGGGCAGATGAATGACTGTCCACTACACTATACCGAAAAGAAAGCGGCTTAAC

>CP036175|1|1|729534-729973|PILER-CR
AGGTGATTAAAAGGGAAGATGAATGACTGTCCACGACGCTATACTGAAAAGAAAGCGGCTTAAC	GGTCAGCTTCCTCATTCAACAAAACCCCGTCAGAAATGGCGGGGTTTTTGCTTTCTGGTACAGGTG
AATAAAAAGGGAAGATGAATGACTGTCCACGACGCTATACCGAAAAGAAAGCGGCTTAACGGTC	AGCTTCCTCATTCAACAAAACCCCGTCAGAAATGGCGGGGTTTTTGCTTTCTGGTACAGGT
GATTAAAAGGGCAGATGAATGACTGTCCACGACGCTATACCGAAAAGAAAGCGGCTTAACGGTC	AGCTTCAACTTTTCAGAAAACCCCGTCAGAAATGGCGGGGTTTTTGCTTTCTGGTACAGGT
GATTAAAAGGGCAGATGAATGACTGTCCACTACACTATACCGAAAAGAAAGCGGCTTAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP036175.1\|QBG06313.1\|720881_721712_+\|DeoR/GlpR-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
CP036175.1\|QBG06318.1\|726973_727864_+\|2-hydroxy-3-oxopropionate-reductase	unknown	unknown	gnl\|CDD\|183197
CP036175.1\|QBG06323.1\|734244_734637_-\|DoxX-family-protein	unknown	unknown	gnl\|CDD\|225168
CP036175.1\|QBG06320.1\|730320_730731_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226203
CP036175.1\|QBG06324.1\|734888_735188_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372871
CP036175.1\|QBG06315.1\|722721_724293_-\|galactarate-dehydratase	unknown	unknown	gnl\|CDD\|274491
CP036175.1\|QBG06325.1\|735184_735583_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227681
CP036175.1\|QBG11012.1\|733188_734175_-\|glutathione-S-transferase-family-protein	unknown	unknown	gnl\|CDD\|223512
CP036175.1\|QBG06321.1\|730953_731655_-\|pirin-family-protein	unknown	unknown	gnl\|CDD\|224655
CP036175.1\|QBG06312.1\|719711_720566_-\|tagatose-bisphosphate-family-class-II-aldolase	unknown	unknown	gnl\|CDD\|183710
CP036175.1\|QBG11011.1\|731759_732656_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176122
CP036175.1\|QBG06322.1\|732693_733062_-\|DUF805-domain-containing-protein	unknown	unknown	gnl\|CDD\|225694
CP036175.1\|QBG06311.1\|718772_719687_-\|1-phosphofructokinase	unknown	unknown	gnl\|CDD\|274804
CP036175.1\|QBG06319.1\|727929_729075_+\|glycerate-2-kinase	unknown	unknown	gnl\|CDD\|182392
CP036175.1\|QBG06317.1\|726174_726945_+\|2-dehydro-3-deoxyglucarate-aldolase	unknown	unknown	gnl\|CDD\|182547
CP036175.1\|QBG06326.1\|735585_735891_-\|DUF883-domain-containing-protein	unknown	unknown	gnl\|CDD\|226941
CP036175.1\|QBG06316.1\|724811_726146_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|273326
CP036175.1\|QBG06310.1\|717349_718762_-\|PTS-fructose-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|224218
CP036175.1\|QBG06327.1\|735936_736305_-\|DUF1090-domain-containing-protein	unknown	unknown	gnl\|CDD\|368932
CP036175.1\|QBG06314.1\|721722_722670_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|238571

Protein	Function_ID	Function_description	E-value
CP036175.1\|QBG06313.1\|720881_721712_+\|DeoR/GlpR-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	3.45738e-43
CP036175.1\|QBG06318.1\|726973_727864_+\|2-hydroxy-3-oxopropionate-reductase	gnl\|CDD\|183197	PRK11559, garR, tartronate semialdehyde reductase; Provisional.	0
CP036175.1\|QBG06323.1\|734244_734637_-\|DoxX-family-protein	gnl\|CDD\|225168	COG2259, COG2259, Predicted membrane protein [Function unknown].	3.15326e-23
CP036175.1\|QBG06320.1\|730320_730731_+\|hypothetical-protein	gnl\|CDD\|226203	COG3678, CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism].	3.83961e-17
CP036175.1\|QBG06324.1\|734888_735188_-\|hypothetical-protein	gnl\|CDD\|372871	pfam13997, YqjK, YqjK-like protein. The YqjK-like protein family includes the E. coli YqjK protein, which is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue R that may be functionally important.	5.95717e-19
CP036175.1\|QBG06315.1\|722721_724293_-\|galactarate-dehydratase	gnl\|CDD\|274491	TIGR03248, galactar-dH20, galactarate dehydratase. Galactarate dehydratase converts D-galactarate to 5-dehydro-4-deoxyglucarate which is subsequently acted on by GarL, tartronate semialdehyde reductase and glycerate kinase (GenProp0714).	0
CP036175.1\|QBG06325.1\|735184_735583_-\|hypothetical-protein	gnl\|CDD\|227681	COG5393, COG5393, Predicted membrane protein [Function unknown].	4.88092e-49
CP036175.1\|QBG11012.1\|733188_734175_-\|glutathione-S-transferase-family-protein	gnl\|CDD\|223512	COG0435, ECM4, Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	0
CP036175.1\|QBG06321.1\|730953_731655_-\|pirin-family-protein	gnl\|CDD\|224655	COG1741, COG1741, Pirin-related protein [General function prediction only].	1.29642e-64
CP036175.1\|QBG06312.1\|719711_720566_-\|tagatose-bisphosphate-family-class-II-aldolase	gnl\|CDD\|183710	PRK12737, gatY, tagatose-bisphosphate aldolase subunit GatY.	0
CP036175.1\|QBG11011.1\|731759_732656_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176122	cd08431, PBP2_HupR, The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold. HupR, a member of the LysR family, activates hupA transcription under low-iron conditions in the presence of hemin. The expression of many iron-uptake genes, such as hupA, is regulated at the transcriptional level by iron and an iron-binding repressor protein called Fur (ferric uptake regulation). Under iron-abundant conditions with heme, the active Fur repressor protein represses transcription of the iron-uptake gene hupA, and prevents transcriptional activation via HupR. Under low-iron conditions with heme, the Fur repressor is inactive and transcription of the hupA is allowed. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.33156e-53
CP036175.1\|QBG06322.1\|732693_733062_-\|DUF805-domain-containing-protein	gnl\|CDD\|225694	COG3152, COG3152, Predicted membrane protein [Function unknown].	5.07257e-40
CP036175.1\|QBG06311.1\|718772_719687_-\|1-phosphofructokinase	gnl\|CDD\|274804	TIGR03828, pfkB, 1-phosphofructokinase. This enzyme acts in concert with the fructose-specific phosphotransferase system (PTS) which imports fructose as fructose-1-phosphate. The action of 1-phosphofructokinase results in beta-D-fructose-1,6-bisphosphate and is an entry point into glycolysis (GenProp0688).	2.68656e-120
CP036175.1\|QBG06319.1\|727929_729075_+\|glycerate-2-kinase	gnl\|CDD\|182392	PRK10342, PRK10342, glycerate kinase I; Provisional.	0
CP036175.1\|QBG06317.1\|726174_726945_+\|2-dehydro-3-deoxyglucarate-aldolase	gnl\|CDD\|182547	PRK10558, PRK10558, alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional.	0
CP036175.1\|QBG06326.1\|735585_735891_-\|DUF883-domain-containing-protein	gnl\|CDD\|226941	COG4575, ElaB, Uncharacterized conserved protein [Function unknown].	2.98081e-37
CP036175.1\|QBG06316.1\|724811_726146_+\|MFS-transporter	gnl\|CDD\|273326	TIGR00893, Probable_glucarate_transporter, D-galactonate transporter. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	1.03987e-134
CP036175.1\|QBG06310.1\|717349_718762_-\|PTS-fructose-transporter-subunit-IIC	gnl\|CDD\|224218	COG1299, FruA, Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism].	1.7703e-124
CP036175.1\|QBG06327.1\|735936_736305_-\|DUF1090-domain-containing-protein	gnl\|CDD\|368932	pfam06476, DUF1090, Protein of unknown function (DUF1090). This family consists of several bacterial proteins of unknown function and is known as YqjC in E. coli.	2.47732e-31
CP036175.1\|QBG06314.1\|721722_722670_+\|sugar-kinase	gnl\|CDD\|238571	cd01166, KdgK, 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources.	1.68843e-94

>CP036175.1|QBG06319.1|727929_729075_+|glycerate-2-kinase
MKIVIAPDSYKESLSATEVAQAIEKGFREIFPDALYVKVPLADGGEGTVEAMIAATQGTEMSACVTGPLGVPVDACWGLSGDGKTAFIEMAAASGLGLVPPAQRNPLLTTSRGTGELILQALESGAKNIIIGIGGSATNDGGAGMVQALGARLCDANGVEIGNGGGSLCNLNSIDISGLDARLRDCVIRVACDVTNPLIGDTGASRIFGPQKGATEAMIRTLDTNLDHYADIILADLHVDVKQVAGAGAAGGMGAALMAFLNAELRSGIEIVTQALNLEEHILDCSLVVTGEGRLDSQSINGKVPVGVASVAKKYHKPVIGIAGSLTRDVGVVHQYGIDAVFSVLTSVTTLEEAFRGAADNIYHASRNIAATLQVGMATEG
>CP036175.1|QBG06318.1|726973_727864_+|2-hydroxy-3-oxopropionate-reductase
MTMKVGFIGLGIMGKPMSKNLLKAGYSLVVADRNPDAIAEVIAAGAETATSAKAIAEQCDVIITMLPNSPHVKEVALGEGGIIEGAKPGTVLIDMSSIAPLASREISEALKAKGVDMLDAPVSGGEPKAIDGTLSVMVGGDKAIFDKYYDLLKAMAGSVVHTGDIGAGNVTKLANQVIVALNIAAMSEALTLATKAGVNPDLVYQAIRGGLAGSTVLDAKAPMVMDRNFKPGFRIDLHIKDLANALDTSHGVGAQLPLTAAVMEMMQALRADGLGTADHSAIACYYEKLAKVEVTR
>CP036175.1|QBG06317.1|726174_726945_+|2-dehydro-3-deoxyglucarate-aldolase
MNNDIFPNKFKAALAAHQVQIGCWSALASPISTEVLGLAGFDWLVLDGEHAPNDISTFIPQLMALKGSTSAPVVRVPTNEPVVIKRLLDIGFYNFLIPFVETEEEAVNAVASTRYPPEGIRGVSVSHRANMFGTVPDYFAQSNKNITILVQIESQQGVDNVDAIAATPGVDGIFVGPSDLAAALGHLGNASHPEVQKAIQHIFAVAKKHGKPSGILAPVEADARRYLEWGATFVAVGSDLGVFRSGTQKLADSFKK
>CP036175.1|QBG06316.1|724811_726146_+|MFS-transporter
MSVDAAIEQKKGMPTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAISMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDVFPLAWAGISMFIMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTGLWVKFVHNPTDHPRMTKEELKFISENGAVVDMDHKKPGSAAASGPKLHYIKQLLTNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGFSITVARKLPIVLGMLLASTIILCNYTDNTVLVVSLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAMVCYLFIVGDIKRMELQK
>CP036175.1|QBG06315.1|722721_724293_-|galactarate-dehydratase
MAEIEIRQESPTAFYIKVHETDNVAIIVNDRGLTAGTRFPDGLTLVEHIPQGHKVALVDIPAHGEIIRYGEVIGYAVRDIAQGSWIDESLVELPEAPPLNTLPLATKVPEPLPPLEGYTFEGYRNADGSVGSKNLLGISTSVHCVAGVVDYVVKIIERDLLPKYPNVDGVVGLNHLYGCGVAINAPAAVVPIRTIHNLALNPNFGGEVMVIGLGCEKLQPERLLEGTDDVKSIPVDSASIVSLQDEKHVGFKSMVDDILQVAERHLEKLNQRQRETCPASELVVGMQCGGSDAFSGVTANPAVGYASDLLVRCGATVMFSEVTEVRDAIHLLTPRAINEEVGKRLLEEMAWYDNYLDMGKTDRSANPSPGNKKGGLANVVEKALGSIAKSGKSAIAEVLSPGQRPTKRGLIYAATPASDFVCGTQQVASGITVQVFTTGRGTPYGLVAVPVIKMATRTELANRWFDLMDINAGTIATGEETIEDVGLKLFEFILDVASGRKKTFSDQWGLHNQLAVFNPAPVT
>CP036175.1|QBG06314.1|721722_722670_+|sugar-kinase
MNVTICTIGELLVEFLAKEENQGFSRPGEFWGPYPSGAPAIFADQVAKLGFGSVLFSCVGNDAFGEMNIARLDADGVNVNGIAILQKATTGSAFVSYRSQAQRDFIFNMPNSACGLLTADHIDERLLGQCNHFHIMGSSLFSFRMIDAMRKAIENIKARNGTVSFDPNIRKEMLNIPEMSQAFEYILDYTDIFLPSDGELDYFGLNPGRDEQVLVDKLLKRGVKHVVIKRGPRGASYFSAQKTHHVAGFNVPVVDPTGAGDCFGATFVSLFLSGASPQEALKWANASGSLAIAQRGPMEGTSTKAQIEAFLKAYK
>CP036175.1|QBG06313.1|720881_721712_+|DeoR/GlpR-transcriptional-regulator
MAKPSTSLLKRRLDIAEIVRKNGEIKVDDLAEMLAVSGVTIRNDLNYLEQQGYLKRSFGGAIYTSQAGAPIALTQETSVATDKALETEMARQIAAQIEDSETLFLGQGSILRKVIPFLAGYDELCLLLNDLAHVPLAQEFLNGETVLLGGVLGGNGKIVEGDLALSALGHYRPSRALVAVDHIAEDGTLSVRQEANARLLSEAVAQSERVIAVVANRPVYGDKRYAMGDLRQISGIVTPQVVAAEYHARLLAAGLTNSYTNNECLTWLNPALQKAK
>CP036175.1|QBG06312.1|719711_720566_-|tagatose-bisphosphate-family-class-II-aldolase
MYIISSKNMLLKAQRLGYAVPAFNIHNLETMQVVVETAAELRSPLILAGTPGTYSYAGTGNVVAIARDLAKIWDLPLAVHLDHHEDLTDITRKVQAGIRSVMIDGSHSPFEENVALVKSVVELSHRYDASVEAELGRLGGVEDDLVVDAKDALYTNPEQAREFVTRTGIDSLAVAIGTAHGMYAAEPKLDFDRLAAIRDRVDVPLVLHGASGLPDSDIRRAISLGVCKVNVATELKIAFSDALKQYFDENPDANDPRHYMKPAKAAMKDVVRKVIHVCGCEGQL
>CP036175.1|QBG06311.1|718772_719687_-|1-phosphofructokinase
MIHTLTLNTAIDMNIFCDPLKPSAVNRTRHTEYCPNGKGVNVSLILNHYQQPTHVMGIFGGFTGRYIVEELRQQKIKVTPAWVSEPTRINIFINDGTDEYKLVNPGAKIDDDCKQQVIHHLECVSAGDYLVISGSLPPGIESRFYGEIIELCQQKGCEIILDISHPVLRQLLELRPLLIKPNDDELREIFSLDVSNHQQVREAMHTLHQLGARNVLLTMGAEGLYFSDSESVWFCSAPKIDLVSSACAGDAALGAFLSKWLNEEDVTHALALASATGADVAGSAGLGKLQRTDELLQQIQVVQL
>CP036175.1|QBG06310.1|717349_718762_-|PTS-fructose-transporter-subunit-IIC
MKKIIAVTGCPTGIAHTFMAEEALKTAAKKLNVEIKVETNGASGVENAITSEDLKDIYGVIIAADKDVNAERFNGLPVIEVPVKEAIHHPADLINKVISGQATRRQGISSTQESTEKYEQESFGRQVYKHLMSGVSNMLPFVVAGGILIAISFLWGIYSADPNSPQYNVIAATLMKVGQQAFSIMVPIFTAYIAWSISGRPGMVAGFVGGLLANATGAGFLGGIIAGFAAGYFMLLIRNMLNGLPRQYEGLKSIFIMPLVGVLVIGVMMVLLGQPVAAINNAMMNWLSSLQEANPILLGIVVGAMCSFDFGGPVNKAAYVTGTLLLGQGNYFFMAGVSAACITPPLVIALATTFFPKGFSEEERAAGMVNYILGCTHITEGAIPFAAKDPLRVIPMMMIASSISAVLSYSLQIQVPAPHGGFLILPLVSKPLMWVLCILAGSACGAVMLGCWRLWQKRTQEATALAGAIK
>CP036175.1|QBG06320.1|730320_730731_+|hypothetical-protein
MKLMTRIVFTAVLASGFSMAAQAADVKAAPAPAQDPIVQHLKLTNDQVTKIKSLHQQLEKNVQQISQKDIKDGVLFDVIDSGKWNEKAVKDQLAAFSKVEQQVRYYRVKYYFGVNQVLTPEQRKQVQKDLAQELSE
>CP036175.1|QBG06321.1|730953_731655_-|pirin-family-protein
MITTRTAKQCGQADFGWLQARYTFSFGHYFDPKLLGYASLRVLNQEVLAPGASFQPRTYPKVDILNLILEGEAEYRDSDGNHIQAKAGEALLISTQPGVSYSEHNLSKEGSLTRMQLWLDACPQHENPLVQKIAIASGPQQLLASPDGSQNSLQLRQQVWIHHIELAKGEQLSVQLHGPRAYLQSIHGTVHALVQEEEKQALTCGDGAFIRDEANITLVADTPLRALLIDLPV
>CP036175.1|QBG11011.1|731759_732656_+|LysR-family-transcriptional-regulator
MAKERALTLEALRVMDAIDRRGSFAAAADELGRVPSALSYTMQKLEEELDVVLFDRSGHRTKFTNVGRMLLERGRVLLEAADKLTTDAEALSRGWETHLTLVTEALVPTTNLFPLIEKLATKSNTQLSIITEVLAGAWERLEQGRADIVVAPDMHFRSSSEINSRKLYSVTSVYVAAPDHPIHQEPEPLSEVTRVKYRGVAVADTARERPVLTVQLLDKQPRLTVSTIEDKRQALLAGLGVATMPYPLVEQDIAEGRLRVVSPEYSNEVDIIMAWRRDSMGEAKSWCLREIPKLFMNR
>CP036175.1|QBG06322.1|732693_733062_-|DUF805-domain-containing-protein
MDWYLKVLQNYLGFGGRARRKEYWMFILVNIILTGVLSIIDKMLGWQRAGGEGILTTIYAILVFLPWWAVQFRRLHDTDRSAWWLLLLLIPVIGWLVIIIFNCQNGTPGNNRFGPDPKPTSY
>CP036175.1|QBG11012.1|733188_734175_-|glutathione-S-transferase-family-protein
MGQLIDGVWHDTWYDTQSTGGRFKRSVSAFRNWLTADGAPGPGGEPGFPAEKDRYHLYVSLACPWAHRTLILRSLKGLEPFISVSVVNPLMFENGWTFDDSFPAATGDTLYQHEFLYQLYLHADPQYSGRVTVPVLWDKKQHTIVSNESAEIIRMFNSAFDGLGARAGDYYPPELRDQIDELNGWIYDNVNNGVYKAGFATSQQAYDEAVDAVFTSLERLEQILGQHRFLTGNQLTEADIRLWTTLVRFDPVYVTHFKCDKHRISDYLNLYGFLRDIYQMSGIAETVDFAHIRNHYYRSHKTINPTGIISIGPQQDLSEPHGRDLRFR
>CP036175.1|QBG06323.1|734244_734637_-|DoxX-family-protein
MKKLEDVGVLVARILMPILFITAGWGKITGYAGTQQYMEAMGVPGFMLPLVILLEFGGGLAILFGFLTRTTALFTAGFTVLTAFLFHSNFAEGVNSLIFMKNLTIAGGFLLLGITGPGAFSIDRVLNKKW
>CP036175.1|QBG06324.1|734888_735188_-|hypothetical-protein
MSRDQQERERQKARLLRLIQQQRLDLNASRRDWLEATAPIDRGWHTLLNLRSWAMVGSGLIAVWSVRHPRFLLRWTKRSFGLWSTWRMARSLLRQQSTR
>CP036175.1|QBG06325.1|735184_735583_-|hypothetical-protein
MANSQHTQGPGQSVFGIGQRIVTLLVEMVETRLRLVVVELEEEKANLFQLFLMLGLTLLFAAFGLMSLLVLIIWAVDAQYRLNVMIATTVTLLLAALIGGIWTLSKARRSTFLRLTRQELANDRSLLEDDKP
>CP036175.1|QBG06326.1|735585_735891_-|DUF883-domain-containing-protein
MAKDNVAEDLRAELKTLADTLEEVLNSSTDKSKEEIGKLRSKAESALKESRVRLGETSDAIVKQTRETAARADEYVRENPWTGVGIGAAVGLVLGVLLTRR
>CP036175.1|QBG06327.1|735936_736305_-|DUF1090-domain-containing-protein
MKHRIALILVLSSLSASAFAISPCQEKEQDIQREISYAEKHHNQNRIDGLNRALSEVRANCSDSKLKAEHQQKIAKQQAEIAERQNDLREAEQKGDADKISKRQHKLDEAQQELKTLQSREY

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Crispr_ID: CP036175_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP036175_2

1211635-1211965

Orphan

I-E

Consensus_repeat	Method
GTGTTCCCCGCGCCAGCGGGGATAAACTG	PILER-CR
GTGTTCCCCGCGCCAGCGGGGATAAACTGG	CRISPRCasFinder
GTGTTCCCCGCGCCAGCGGGGATAAAC	CRT

5 spacers

The CRISPR arrays of CP036175_2

>merge|CP036175|2|1211635-1211965|PILER-CR,CRISPRCasFinder,CRT
GTGTTCCCCGCGCCAGCGGGGATAAACTGCTCTATCCCCAGCACGTGCCGGTAGTAAAGCAGTGTTCCCCGCGCCAGCGGGGATAAACTGGGTTTGGTTTATCTGGCCGCTTGTGGAGGCGTGTGTTCCCCGCGCCAGCGGGGATAAACTGGCGGTTGCAAGGTTATCCTGGAATACAAACGTGTGTTCCCCGCGCCAGCGGGGATAAACCGCTGTTATGGCTGATATCCGTGTAATCGGCGACGTGTTCCCCGCGCCAGCGGGGATAAACCGCTAATTAACCTGACGAATATAAGTACTGGGGGGGGCCGCGCCAGCGAGGATAAACCGA

>CP036175|2|2|1211635-1211907|PILER-CR
GTGTTCCCCGCGCCAGCGGGGATAAACTG	CTCTATCCCCAGCACGTGCCGGTAGTAAAGCA
GTGTTCCCCGCGCCAGCGGGGATAAACTG	GGTTTGGTTTATCTGGCCGCTTGTGGAGGCGT
GTGTTCCCCGCGCCAGCGGGGATAAACTG	GCGGTTGCAAGGTTATCCTGGAATACAAACGT
GTGTTCCCCGCGCCAGCGGGGATAAACCG	CTGTTATGGCTGATATCCGTGTAATCGGCGAC
GTGTTCCCCGCGCCAGCGGGGATAAACCG

>CP036175|2|1|1211635-1211965|CRISPRCasFinder
GTGTTCCCCGCGCCAGCGGGGATAAACTGC	TCTATCCCCAGCACGTGCCGGTAGTAAAGCA
GTGTTCCCCGCGCCAGCGGGGATAAACTGG	GTTTGGTTTATCTGGCCGCTTGTGGAGGCGT
GTGTTCCCCGCGCCAGCGGGGATAAACTGG	CGGTTGCAAGGTTATCCTGGAATACAAACGT
GTGTTCCCCGCGCCAGCGGGGATAAACCGC	TGTTATGGCTGATATCCGTGTAATCGGCGAC
GTGTTCCCCGCGCCAGCGGGGATAAACCGC	TAATTAACCTGACGAATATAAGTACTG
GGGGGGGCCGCGCCAGCGAGGATAAACCGA

>CP036175|2|1|1211635-1211962|CRT
GTGTTCCCCGCGCCAGCGGGGATAAAC	TGCTCTATCCCCAGCACGTGCCGGTAGTAAAGCA
GTGTTCCCCGCGCCAGCGGGGATAAAC	TGGGTTTGGTTTATCTGGCCGCTTGTGGAGGCGT
GTGTTCCCCGCGCCAGCGGGGATAAAC	TGGCGGTTGCAAGGTTATCCTGGAATACAAACGT
GTGTTCCCCGCGCCAGCGGGGATAAAC	CGCTGTTATGGCTGATATCCGTGTAATCGGCGAC
GTGTTCCCCGCGCCAGCGGGGATAAAC	CGCTAATTAACCTGACGAATATAAGTACTG
GGGGGGGCCGCGCCAGCGAGGATAAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP036175.1\|QBG06735.1\|1205758_1206550_+\|nucleoside-triphosphate-pyrophosphohydrolase	unknown	unknown	gnl\|CDD\|236569
CP036175.1\|QBG06734.1\|1203448_1205689_+\|GTP-diphosphokinase	unknown	unknown	gnl\|CDD\|182797
CP036175.1\|QBG06732.1\|1199101_1201855_-\|two-component-sensor-histidine-kinase-BarA	unknown	unknown	gnl\|CDD\|236848
CP036175.1\|QBG06737.1\|1208495_1209794_+\|phosphopyruvate-hydratase	unknown	unknown	gnl\|CDD\|234617
CP036175.1\|QBG06729.1\|1195147_1196488_+\|glucarate-dehydratase	unknown	unknown	gnl\|CDD\|211799
CP036175.1\|QBG06743.1\|1217746_1219201_+\|FAD-binding-oxidoreductase	unknown	unknown	gnl\|CDD\|223354
CP036175.1\|QBG06745.1\|1222453_1223029_-\|glycerol-3-phosphate-responsive-antiterminator	unknown	unknown	gnl\|CDD\|224865
CP036175.1\|QBG06733.1\|1201978_1203319_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	unknown	unknown	gnl\|CDD\|237291
CP036175.1\|QBG06740.1\|1213442_1214921_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|212662
CP036175.1\|QBG06746.1\|1223050_1223311_-\|ferredoxin-family-protein	unknown	unknown	gnl\|CDD\|225289
CP036175.1\|QBG06731.1\|1197920_1199060_+\|glycerate-kinase	unknown	unknown	gnl\|CDD\|376844
CP036175.1\|QBG06747.1\|1223301_1224573_-\|FAD-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|182194
CP036175.1\|QBG06741.1\|1214947_1216246_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|349949
CP036175.1\|QBG11028.1\|1221503_1222373_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	unknown	unknown	gnl\|CDD\|224936
CP036175.1\|QBG06738.1\|1209860_1210970_-\|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl\|CDD\|187547
CP036175.1\|QBG06739.1\|1212731_1213403_+\|7-carboxy-7-deazaguanine-synthase-QueE	unknown	unknown	gnl\|CDD\|275126
CP036175.1\|QBG06744.1\|1220724_1221507_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	unknown	unknown	gnl\|CDD\|224997
CP036175.1\|QBG06736.1\|1206777_1208415_+\|CTP-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl\|CDD\|235437
CP036175.1\|QBG06742.1\|1216690_1217476_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187605
CP036175.1\|QBG06730.1\|1196509_1197850_+\|glucarate-dehydratase	unknown	unknown	gnl\|CDD\|211799

Protein	Function_ID	Function_description	E-value
CP036175.1\|QBG06735.1\|1205758_1206550_+\|nucleoside-triphosphate-pyrophosphohydrolase	gnl\|CDD\|236569	PRK09562, mazG, nucleoside triphosphate pyrophosphohydrolase; Reviewed.	1.18179e-160
CP036175.1\|QBG06734.1\|1203448_1205689_+\|GTP-diphosphokinase	gnl\|CDD\|182797	PRK10872, relA, (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional.	0
CP036175.1\|QBG06732.1\|1199101_1201855_-\|two-component-sensor-histidine-kinase-BarA	gnl\|CDD\|236848	PRK11107, PRK11107, hybrid sensory histidine kinase BarA; Provisional.	0
CP036175.1\|QBG06737.1\|1208495_1209794_+\|phosphopyruvate-hydratase	gnl\|CDD\|234617	PRK00077, eno, enolase; Provisional.	0
CP036175.1\|QBG06729.1\|1195147_1196488_+\|glucarate-dehydratase	gnl\|CDD\|211799	TIGR03247, glucar-dehydr, glucarate dehydratase. Glucarate dehydratase converts D-glucarate (and L-idarate, a stereoisomer) to 5-dehydro-4-deoxyglucarate which is subsequently acted on by GarL, tartronate semialdehyde reductase and glycerate kinase (GenProp0716). The E. coli enzyme has been well-characterized.	0
CP036175.1\|QBG06743.1\|1217746_1219201_+\|FAD-binding-oxidoreductase	gnl\|CDD\|223354	COG0277, GlcD, FAD/FMN-containing dehydrogenases [Energy production and conversion].	2.0839e-77
CP036175.1\|QBG06745.1\|1222453_1223029_-\|glycerol-3-phosphate-responsive-antiterminator	gnl\|CDD\|224865	COG1954, GlpP, Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription].	2.13247e-87
CP036175.1\|QBG06733.1\|1201978_1203319_+\|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD	gnl\|CDD\|237291	PRK13168, rumA, 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD.	0
CP036175.1\|QBG06740.1\|1213442_1214921_-\|sugar-kinase	gnl\|CDD\|212662	cd07779, FGGY_ygcE_like, uncharacterized ygcE-like proteins. This subfamily consists of uncharacterized hypothetical bacterial proteins with similarity to Escherichia coli sugar kinase ygcE , whose functional roles are not yet clear. Escherichia coli ygcE is recognized by this model, but is not present in the alignment as it contains a deletion relative to other members of the group. These proteins belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	1.37701e-113
CP036175.1\|QBG06746.1\|1223050_1223311_-\|ferredoxin-family-protein	gnl\|CDD\|225289	COG2440, FixX, Ferredoxin-like protein [Energy production and conversion].	3.40463e-33
CP036175.1\|QBG06731.1\|1197920_1199060_+\|glycerate-kinase	gnl\|CDD\|376844	pfam02595, Gly_kinase, Glycerate kinase family. This is family of Glycerate kinases.	0
CP036175.1\|QBG06747.1\|1223301_1224573_-\|FAD-dependent-oxidoreductase	gnl\|CDD\|182194	PRK10015, PRK10015, oxidoreductase; Provisional.	1.30042e-130
CP036175.1\|QBG06741.1\|1214947_1216246_-\|MFS-transporter	gnl\|CDD\|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	3.35475e-31
CP036175.1\|QBG11028.1\|1221503_1222373_+\|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	4.92292e-61
CP036175.1\|QBG06738.1\|1209860_1210970_-\|NAD-dependent-epimerase/dehydratase-family-protein	gnl\|CDD\|187547	cd05236, FAR-N_SDR_e, fatty acyl CoA reductases (FARs), extended (e) SDRs. SDRs are Rossmann-fold NAD(P)H-binding proteins, many of which may function as fatty acyl CoA reductases (FAR), acting on medium and long chain fatty acids, and have been reported to be involved in diverse processes such as biosynthesis of insect pheromones, plant cuticular wax production, and mammalian wax biosynthesis. In Arabidopsis thaliana, proteins with this particular architecture have also been identified as the MALE STERILITY 2 (MS2) gene product, which is implicated in male gametogenesis. Mutations in MS2 inhibit the synthesis of exine (sporopollenin), rendering plants unable to reduce pollen wall fatty acids to corresponding alcohols. This N-terminal domain shares the catalytic triad (but not the upstream Asn) and characteristic NADP-binding motif of the extended SDR family. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	7.69869e-64
CP036175.1\|QBG06739.1\|1212731_1213403_+\|7-carboxy-7-deazaguanine-synthase-QueE	gnl\|CDD\|275126	TIGR04322, organic_radical_activating_enzyme, putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE. Members of this radical SAM domain protein family appear to be the E. coli form of the queuosine biosynthesis protein QueE. QueE is involved in making preQ0 (7-cyano-7-deazaquanine), a precursor of both the bacterial/eukaryotic modified tRNA base queuosine and the archaeal modified base archaeosine. Members occur in species that lack known forms of QueE but usually are not found in queuosine biosynthesis operons. Members of this family tend to form bi-directional best hit matches to members of known (TIGR03365) and putative (TIGR03963) QueE families from other lineages.	1.15075e-152
CP036175.1\|QBG06744.1\|1220724_1221507_+\|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein	gnl\|CDD\|224997	COG2086, FixA, Electron transfer flavoprotein, beta subunit [Energy production and conversion].	2.1735e-47
CP036175.1\|QBG06736.1\|1206777_1208415_+\|CTP-synthase-(glutamine-hydrolyzing)	gnl\|CDD\|235437	PRK05380, pyrG, CTP synthetase; Validated.	0
CP036175.1\|QBG06742.1\|1216690_1217476_+\|SDR-family-oxidoreductase	gnl\|CDD\|187605	cd05347, Ga5DH-like_SDR_c, gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs. Ga5DH catalyzes the NADP-dependent conversion of carbon source D-gluconate and 5-keto-D-gluconate. This SDR subgroup has a classical Gly-rich NAD(P)-binding motif and a conserved active site tetrad pattern. However, it has been proposed that Arg104 (Streptococcus suis Ga5DH numbering), as well as an active site Ca2+, play a critical role in catalysis. In addition to Ga5DHs this subgroup contains Erwinia chrysanthemi KduD which is involved in pectin degradation, and is a putative 2,5-diketo-3-deoxygluconate dehydrogenase. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107,15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	7.13498e-136
CP036175.1\|QBG06730.1\|1196509_1197850_+\|glucarate-dehydratase	gnl\|CDD\|211799	TIGR03247, glucar-dehydr, glucarate dehydratase. Glucarate dehydratase converts D-glucarate (and L-idarate, a stereoisomer) to 5-dehydro-4-deoxyglucarate which is subsequently acted on by GarL, tartronate semialdehyde reductase and glycerate kinase (GenProp0716). The E. coli enzyme has been well-characterized.	0

>CP036175.1|QBG06738.1|1209860_1210970_-|NAD-dependent-epimerase/dehydratase-family-protein
MNTLLITGVTGFLGGAVLENILNQENRFNLLLLVRANDDAAALERVKENLRKFNIAEEKLAALNSRSILLGDLADPEVFLTDPRLDQVTHVINCAAIASFGNNPLIWKVNVEGTLKFVRRMAQIISLQRFLHVGTAMSCSPEQDSLVAENAEFRERAEHLVEYTHSKSTIERLMQQECPTLPLVIARPSIVVGHTHHGCQPSSSIFWVFSMGLMLQKFMCSMEDRIDVIPVDYCADALLMLLNSPLARGEIVHISAGEENSVRFADIDSAMASALEQAPVGNKYAQVSYETLVKMRRELKDIFGPCNERLMLKAIRLYGAFATLNVRFSNDKLLSMGMPKPPRFTDYIDRCVQTTRGLSIPQQMAVDFK
>CP036175.1|QBG06737.1|1208495_1209794_+|phosphopyruvate-hydratase
MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFMGKGVLKAVGAVNGPIAQAILGKDAKDQAGIDKIMIDLDGTENKSNFGANAILAVSLANAKAAAASKGQPLYEHIAELNGTPGKYSMPVPMMNIINGGEHADNNVDIQEFMIQPVGAKSLKEAVRMGSEVFHNLAKVLKAKGMNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGTDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIEKGIVNSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA
>CP036175.1|QBG06736.1|1206777_1208415_+|CTP-synthase-(glutamine-hydrolyzing)
MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTMMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMTRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLAGGEGHDVVLVEIGGTVGDIESLPFLEAIRQLAVDIGRENALFMHLTLVPYLAAAGEVKTKPTQHSVKELLSIGIQPDILVCRSDRAIPANERAKIALFCNVPEKAVISMKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLAEWEQVIYEEANPAGEVTIGMVGKYIELPDAYKSVIEALKHGGLKNRVTVNIKLIDSQDVETRGVEILKNLDAILIPGGFGYRGVEGKIATARYARENNIPYLGICLGMQVALIEFARNVAGMENANSTEFVPDCKYPVVALITEWRDEEGNVEVRSDKSDLGGTMRLGAQQCQLSDDSLVRQLYGEPTITERHRHRYEVNNMLLKPIENAGLRIAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKAAGEYQKRQAK
>CP036175.1|QBG06735.1|1205758_1206550_+|nucleoside-triphosphate-pyrophosphohydrolase
MTQIDRLLGIMQRLRDPENGCPWDKEQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDICAAISDKLERRHPHIFGDASAGNSSEVLARWEQIKSAERAEKSQHSALDDIPHSLPALMRAHKIQRRCSAVGFDWTSLGPVLDKVHEEIDEVMHEAQQAVIDEAKLEEEVGDLLFATVNLSRHLGVKAEVALQKANLKFERRFREVERIVAARGLEMTGVDLDTMEDVWQEVKRQETDL
>CP036175.1|QBG06734.1|1203448_1205689_+|GTP-diphosphokinase
MVAVRSAHLNKAGEFDPKKWIASLGISSQQSCERLAETWDYCREKTQGHPQADLLLWRGVEMVEILSMLSMDIDTLRAALLFPLADGNVVSEEVMQESVGKSVVTLIHGVRDMAAIRQLKATHTDSVSSEQVDNIRRMLLAMVDDFRCVVIKLAERIAHLREVKDAPEDERVLAAKECTNIYAPLANRLGIGQLKWELEDYCFRYLHPAEYKRIAKLLHERRIDREHYIDEFVGHLRSEMKTEGVKAEVYGRPKHIYSIWRKMQKKHLAFDELFDVRAVRIVAERLQDCYAALGIVHTHYRHLPDEFDDYVANPKPNGYQSIHTVVLGPGGKTIEIQIRTKQMHEDAELGVAAHWKYKEGASAGASGARGYEDRIAWLRKLIAWQEEMADSGEMLDEVRSQVFDDRVYVFTPKGDVVDLPAGSTPLDFAYHIHSDVGHRCIGAKISGRIVPFTYQLQMGDQIEIITQKQPNPSRDWLNPNLGYVTTSRGRSKIHAWFRKQDRDKNILAGRQILDDELEHLGISLKDAEKHLLPRYNFNEQDELLAAIGGGDIRLNQMVNFLQAQFNKPSAEEQDAAALKQLQQKTYTPQNNRSKDNGRVVVEGVGNLMHHIARCCQPIPGDEIVGFITQGRGISVHRADCDQLAELQSHAPERIVDAVWGESYSAGYSLVVRVQANDRSGLLRDITTILANEKVNVLGVASRSDTKQQLATIDMTIEIYNLQVLGRVLGRLNQVPDVIDARRLHGG
>CP036175.1|QBG06733.1|1201978_1203319_+|23S-rRNA-(uracil(1939)-C(5))-methyltransferase-RlmD
MAQFYSAKRRVTTRQIITVTVNDLDPFGQGVARHQGKALFVSGLLPQEQAEVVLVEDKKQYARAQVKRRLSDSPQRETPRCPHFGVCGGCQQQHASIDLQQQSKRAALARLMKRDVDDIIAASPWGYRRRARLSLNYQPKTQQLQVGFRKANSNEIVDVVQCPVLVPTLGALLPAVRECLSELKSVRQLGHVELVLADNGPLMVLRHTATLSAADKEKLERFSQSHGLSLYLAPQSEILEHISGESPWYTSDGLRLVFSPRDFIQVNDGVNQLMVRTALEWLDLQPEDRVLDLFCGMGNFTLPLAKRAAQVVGVEGVPALVEKGRENATFNGLHNVTFFHENLEEDVTRQAWAKHGFDKILLDPARAGAAGVMLHIIKLAPRRVVYVSCNPATLARDSDVLLQAGYTIQRLAMLDMFPHTGHLESMVLFEHKHTQNHSNRIEAATE
>CP036175.1|QBG06732.1|1199101_1201855_-|two-component-sensor-histidine-kinase-BarA
MTNYSLRARMMILILAPTVLIGLLLSIFFVAHRYNDLQRQLEDAGASIIEPLAVSSEYGMNLQNRESIRQLISVLHRRHSDIVRAISIYDSHNKLFVTSNFQLDPGELQLPKGAPFPRRLSVIRNGDLMILRTPIVSESYSPDESPGTDAKMPGNMLGYVALELDLKSVRLQQYKEIFISSVMMLFCIGIALIFGWRLMRDVTGPIRNMVNTVDRIRRGQLDSRVEGFMLGELDMLKNGINSMAMSLAAYHEEMQHNVDQATSDLRETLEQMEIQNVELDLAKKRAQEAARIKSEFLANMSHELRTPLNGVIGFTRLTLKTNLNTTQRDHLTTIERSANNLLAIINDVLDFSKLEAGKLILESIPFLLRNSLDEVVTLLAHSAHDKGLELTLNIKNDVPDNVIGDPLRLQQIVTNLMGNAIKFTEYGNIDVLVEQRTISNSRVQIEVQIHDTGIGIPERDQSRLFQAFRQADASISRRHGGTGLGLVITQRLVKEMGGDISFHSQPNRGSTFWFHISLDLNPNAVPDSVSTDCLTGKKLAYIEANAMAAQCTMELLATTPLEVVYSPTMSALPDAHYDILLAGIPVAVRELEQHRDKLTRACKLADHLLLALPCHAQVSAEALKEDGVAACLLKPLTSTRLLPALTASCQTQPTILLPHSDGKKLPMTVMAVDDNPANLKLIGALLEDLVQHVILCDSGQNAVEEAKEKQLDLILMDIQMPEMDGIRACELIRQLPHQQQTPVIAVTAHALEGQREKLLSAGMNDYLAKPIEEDKLYSLLLRYQPGKNVAPLAVTEAVELPIDHNVTLNWQLALRQAAMKPDLAQEMLQMLIAFMPEVRNRVEEQLVGEQPEGLLDLIHKLHGSCGYSGVPRLKKLCQTIETQLRSGTVAEELEPEFLELLDEMDNVVREACKLMGI
>CP036175.1|QBG06731.1|1197920_1199060_+|glycerate-kinase
MKIVIAPDSYKESLSALDVATAIEQGFREIYPDAEYVKLPVADGGEGTVEAMVAATQGYQVEVTVTGPLGEPVAAFYGLSGDKQCAFIEMAAASGLESVPSARRNPLLTTSWGTGELIRHALDAGVKQIIIGIGGSATNDGGAGMVQALGAKLLTHDNQQIALGGGALDSLARIDISELDERLAECRIDVACDVTNPLTGPQGATAVFGPQKGATAEMIARLDKALAHFAGIIHRDLDLDVLNLEGGGAAGGMGAGLYAFCGAKLRPGIEIVTDALHLADIVADADLVITGEGRIDSQTIHGKVPVGVARVAKRYNLPVIGIAGSLTADVGVVHDHGLDAVFSVIYSICTLDEALENAAENVRMTARNVAAVLKMGQVL
>CP036175.1|QBG06730.1|1196509_1197850_+|glucarate-dehydratase
MSTQFTTPVVTAMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRQTLEDAIPLVVGKTLGEYKNVLNAVRNQFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDEKCDWYRLRHDEAMTPDSVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAKRFPQARVTLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGMVQVPAKPGLGVELDMDQVMKAHELYQKHGLGARDDAMGMQYLIPNWTFDNKRPCMVR
>CP036175.1|QBG06729.1|1195147_1196488_+|glucarate-dehydratase
MTTQSSPVITDMKVIPVAGQDSMLLNIGGAHNAYFTRNIVVLTDNAGNTGVGEAPGGEVIYQTLVDAIPMVLGQEVARLNKVVQQVHKGNQAADFDTFGKGAWTFELRVNAVAALEAALLDLLGKALNVPVCELLGPGKQRDAVTVLGYLFYVGDRTKTDLPYLETTPGNHDWYHLRHQQAMNSEAVVHLAEASQDRYGFKDFKLKGGVLPGEQEIETARALKKRFPDARITVDPNGAWLLDEAIALCKGLNDVLTYAEDPCGAEQGFSGREVMAEFRRATGLPVATNMIATNWREMGHAVMLNSVDIPLADPHFWTLSGAVRVAQLCDDWGLTWGCHSNNHFDISLAMFTHVGAAAPGKPTAIDTHWIWQEGDCRLTKSPLEIKNGKIAVPDAPGLGVELDWDQVNKAHEAYKRLPGGARNDAGPMQYLIPGWTFDRKRPVFGRH
>CP036175.1|QBG06739.1|1212731_1213403_+|7-carboxy-7-deazaguanine-synthase-QueE
MQYPINEMFQTLQGEGYFTGVPAIFIRLQGCPVGCAWCDTKHTWDKLADREVSLFSILAKTKESDKWGPASGEDLLAIIGRQGWTARHVVITGGEPCIHDLTPLTSLLEQNGFSCQIETSGTHEVRCTPHTWVTVSPKVNMRGGYDVLSQALQRADEIKHPVGRVRDIEALDELLETLADEKPRVIALQPISQKDDATRLCIETCIARNWRLSMQTHKYLNIA
>CP036175.1|QBG06740.1|1213442_1214921_-|sugar-kinase
MSKKYIIGIDGGSQSTKVVMYDLQGNVVCEGKGLLQPMHTPDADTAEHPDDDLWTSLCFAGKDLMSQFAGHKEDIVGIGLGSIRCCRALLKADGTPAEPLISWQDARVTRPYEHTNPDVAWVTSFSGYLSHRLTGEFKDNIANYFGQWPVDYKTWSWSDDDEVMKKFNIPRHMLFDVQMPGTILGHLTEQAALATGFPAGLPVVCTTSDKPVEALGAGLLDDETAVISLGTYIALMMNGKQLPKDPVAYWPIMSSIPETLLYEGYGIRKGMWTVSWLRDMLGESLIQDAKAQGLSPEDLLNKKASVVPPGCNGLMTVLDWLTNPWEPYKRGIMIGFDSSMDYAWIYRSILESVALTLKNNYDNMCNEMNHFAKHIIITGGGSNSDLFMQIFADVFNLPARRNAINGCASLGAAINTAVGLGLYPSYEAAIENMVRVKDEFIPVEQNASRYEALNKGIFRELTQHTDVILKKSYQVIHGNLDDVDAIQSWSNA
>CP036175.1|QBG06741.1|1214947_1216246_-|MFS-transporter
MQQTSYRRWITLAIISFSGGVSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQVAFAITTILMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWAFSRFEPDDSNSLKTVIIIYSVVYILLGILCWFFVSDAPQHSNAAKEEKKSFQLSDILAVLRISTTWYCSMVIFGVFTIYAILSYSTNYLTEMYGMSLVAASYMGIVINKIFRAICGPLGGIITTYSKVKSPTRVIQLLSIVGVLALIALLATNSNPQSVAMGIGLILLLGFTCYASRGLYWACPGEARTPSYIMGTTVGICSVIGFLPDVFVYPIVGHWQDTLPAEEAYRNMWLMGLAALCMVILFTFLLFRKIRSADATPENETSLAAETTGE
>CP036175.1|QBG06742.1|1216690_1217476_+|SDR-family-oxidoreductase
MSIESLNAFSMDFFSLKGKTAIVTGGNSGLGQAFAMALAKAGANLFIPSFVKDNGETKEIIEKQGVEVEFMQVDITAKGAPEKIIAACCERFGTVDILVNNAGICKLNKVLDFGRADWDPMIDVNLTAAFELSYEAAKIMIPQNSGKIINICSLFSYLGGQWSPAYSATKHALAGFTKAYCDELGQYNIQVNGIAPGYYATDITLATRSNPETNQRVLDHIPANRWGDTQDLMGAAVFLASQASNYVNGHLLVVDGGYLVR
>CP036175.1|QBG06743.1|1217746_1219201_+|FAD-binding-oxidoreductase
MSLSREAIVDQLKEIVGSDRVITDETVLKRNSIDRFRKYADIHGVFTLPLPAAVVKLGSTEQVSNVLAFMNQHKINGVPRTGASATEGGLETVVENSVVLDGAGMNQILNIDIENMQATAQCGVQLEILENALRAKGYTTGHSPQSKPLAQMGGLVATRSIGQFSTLYGAIEDMVVGLEAVLPDGTITRIKNVPRRAAGPDIRHIIIGNEGALCYITEVTVKIFKFTPENNLFYGYILDDMKVGFNILREVMVEGYRPSIARLYDAEDGTQHFTHFADGKCVLIFMAEGNPRMAKATGEGIAEVVARYPQCQRVDSKLIENWFNHLNWGPEKVAAERVQILKTGNMGFTTEVSGCWSCIHEIYESVIHRIRTEFPHADDITMLGGHSSHSYMNGTNMYFVYDYNVVDCKPEEEIDKYHNPLNKIICEETIRLGGSMVHHHGIGKHRVHWSKLEHGSAWPLLEGLKKQFDPNGIMNTGTIYPIEK
>CP036175.1|QBG06744.1|1220724_1221507_+|electron-transfer-flavoprotein-subunit-beta/FixA-family-protein
MNILLAFKPEPDASMLAEKDWQAAALDTCGPDVSLLRSAIGADEQAAAALLLTQRGAGCEMTLTALSIGDERALHWLRYFAALGFERQVLLEAAGDLRFAPSFIAGQLADWQRSHGAELIVTGCQSSESQNGQTPFLLAEMLDWPCFTQVERFTLEPPFVVVEQRTISGIRRCRVRLPAVIAVRQCGEVALPVPGMRQRLAATKAEVVRQAVTVEVMPVVQCLRLTRPEQRRCAVIIEGTTAQEKARSLWENYLRQRMKP
>CP036175.1|QBG11028.1|1221503_1222373_+|electron-transfer-flavoprotein-subunit-alpha/FixB-family-protein
MKIAIVMATSDSAAMGNWLATNNIGPAELERWIFDAEPDVAEQVLDALVSQWQQTPVDMLIFPAGILGDELATRLAWRLQGGCVCQALSVSTQEGRVTKSHWGNALIATLEVTARPLCLSLARQPGVNTPTDLPADMTTRHIAPAALPDWLISVESVKRSGVHPLQEAKQVLVVGQGGEGVDADNISVLARNLGAEAGYSRARVMNGGYDAERLIGISGHLLAADVCIVAGASGAAALMTGVRDSRFIVAINRDPSAPVFTQADVGIVDDWLPVLDALVACADISPDGG
>CP036175.1|QBG06745.1|1222453_1223029_-|glycerol-3-phosphate-responsive-antiterminator
MPLLHLLRQNPVIAAVKDNASLQLAIDSECQFISVLYGNICTISNIVKKIKNAGKYAFVHVDLLEGASNKEVVIQFLKLVTEADGIISTKAPMLKAARAEGFFCIHRLFIVDSISFHNIDKQVAQSNPDCIEILPGCMPKVLGWVTEKIRQPLIAGGLVCDEEDARNAMKAGVAALSTTNTTVWKLAKQLN
>CP036175.1|QBG06746.1|1223050_1223311_-|ferredoxin-family-protein
MSIARNVWRPADSPHIVPSASPNEKVAELLIKACPAGLFSRTAEGELRVDYRGCLECGTCRLLCDEATLKEWRYPDSGFGITFRFG
>CP036175.1|QBG06747.1|1223301_1224573_-|FAD-dependent-oxidoreductase
MADDFDIIIIGAGIAGTACALRCARAGLSVLLLERGELPGSKNLSGGRLYCHALAELLPHFQQSAPLERRITQESLTLLTANGATTYSSLQPNGDSWSLLRARFDPWFVGQAENEGVQCITGATVEALYRENGRVCGVICDNETLRARYVVLAEGANSELAERHGLVPRPSPSSMALGIKAVLALEQKTLEDRFRLEGNEGAAMLFTGGVCGDLPGGAFLYTNQDTLSFGIVCPLSSLGKAAAPASELLENLKSHPALRPLLRGSETLEYGAHLVPEGGLHSMPVQYGGDGWLLVGDALRTCINTGFTVRGMDMALIGAQAAAQTLIRACQQSTPQNLFAQYHRDVERSVLWEVLQRYQHVPALLQRPGWYRQWPALMEDISRELWQQGERPVPPLRQVVWRHLRRHGLCHLAGDLVRSLRCL

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Crispr_ID: CP036175_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP036175_3

1953811-1953961

Orphan

I-E:NA

Consensus_repeat	Method
ACGTTCCCCACGCGAGTGGGGATAAACCG	PILER-CR
ACGTTCCCCACGCGAGTGGGGATAA	CRISPRCasFinder

2 spacers

The CRISPR arrays of CP036175_3

>merge|CP036175|3|1953811-1953961|PILER-CR,CRISPRCasFinder
ACGTTCCCCACGCGAGTGGGGATAAACCGATTGTCGTTAACTTCTCAGCCGGGAAAGACAGACGTTCCCCACGCGAGTGGGGATAAACCGTCCGATCGTGATGGTTCGGTTCGTCTGGCCGCACGTTCCCCACGCGAGTGGGGATAAGCCG

>CP036175|3|3|1953811-1953961|PILER-CR
ACGTTCCCCACGCGAGTGGGGATAAACCG	ATTGTCGTTAACTTCTCAGCCGGGAAAGACAG
ACGTTCCCCACGCGAGTGGGGATAAACCG	TCCGATCGTGATGGTTCGGTTCGTCTGGCCGC
ACGTTCCCCACGCGAGTGGGGATAAGCCG

>CP036175|3|2|1953811-1953957|CRISPRCasFinder
ACGTTCCCCACGCGAGTGGGGATAA	ACCGATTGTCGTTAACTTCTCAGCCGGGAAAGACAG
ACGTTCCCCACGCGAGTGGGGATAA	ACCGTCCGATCGTGATGGTTCGGTTCGTCTGGCCGC
ACGTTCCCCACGCGAGTGGGGATAA

Protein	Signature genes	Signature genes Name	Protein_function
CP036175.1\|QBG07382.1\|1954206_1954980_+\|hydroxyethylthiazole-kinase	unknown	unknown	gnl\|CDD\|236477
CP036175.1\|QBG07381.1\|1952688_1953636_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
CP036175.1\|QBG07379.1\|1949431_1950775_-\|NCS2-family-permease	unknown	unknown	gnl\|CDD\|225161
CP036175.1\|QBG07375.1\|1940002_1943740_-\|DUF4132-domain-containing-protein	unknown	unknown	gnl\|CDD\|379270
CP036175.1\|QBG07385.1\|1957102_1958710_-\|ribulokinase	unknown	unknown	gnl\|CDD\|212663
CP036175.1\|QBG11060.1\|1947552_1947882_+\|hypothetical-protein	unknown	unknown	unknown
CP036175.1\|QBG07387.1\|1960761_1961703_-\|cytochrome-C-biogenesis-protein-CcdA	unknown	unknown	gnl\|CDD\|367868
CP036175.1\|QBG07388.1\|1961909_1963277_+\|mannitol-dehydrogenase-family-protein	unknown	unknown	gnl\|CDD\|223324
CP036175.1\|QBG07390.1\|1964828_1966106_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|162096
CP036175.1\|QBG07378.1\|1948409_1949303_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176114
CP036175.1\|QBG07380.1\|1950777_1952589_-\|adenine-deaminase	unknown	unknown	gnl\|CDD\|223933
CP036175.1\|QBG11059.1\|1943878_1945912_-\|methionine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234655
CP036175.1\|QBG07383.1\|1954976_1955777_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	unknown	unknown	gnl\|CDD\|180561
CP036175.1\|QBG07389.1\|1963286_1964750_+\|xylulokinase	unknown	unknown	gnl\|CDD\|198374
CP036175.1\|QBG07377.1\|1947926_1948241_-\|nickel/cobalt-homeostasis-protein-RcnB	unknown	unknown	gnl\|CDD\|227742
CP036175.1\|QBG11061.1\|1958739_1959468_-\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|226674
CP036175.1\|QBG07384.1\|1955925_1956978_+\|class-I-fructose-bisphosphate-aldolase	unknown	unknown	gnl\|CDD\|236431
CP036175.1\|QBG07386.1\|1959745_1960747_+\|LacI-family-DNA-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380498
CP036175.1\|QBG07374.1\|1936255_1939990_-\|DUF4132-domain-containing-protein	unknown	unknown	gnl\|CDD\|379270
CP036175.1\|QBG07376.1\|1946063_1947173_+\|iron-sulfur-cluster-carrier-protein-ApbC	unknown	unknown	gnl\|CDD\|183270

Protein	Function_ID	Function_description	E-value
CP036175.1\|QBG07382.1\|1954206_1954980_+\|hydroxyethylthiazole-kinase	gnl\|CDD\|236477	PRK09355, PRK09355, hydroxyethylthiazole kinase; Validated.	3.40147e-124
CP036175.1\|QBG07381.1\|1952688_1953636_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.18267e-38
CP036175.1\|QBG07379.1\|1949431_1950775_-\|NCS2-family-permease	gnl\|CDD\|225161	COG2252, COG2252, Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism].	5.34153e-118
CP036175.1\|QBG07375.1\|1940002_1943740_-\|DUF4132-domain-containing-protein	gnl\|CDD\|379270	pfam13569, DUF4132, Domain of unknown function (DUF4132). This domain might be involved in the biosynthesis of the molybdopterin cofactor in E.coli.	3.61322e-61
CP036175.1\|QBG07385.1\|1957102_1958710_-\|ribulokinase	gnl\|CDD\|212663	cd07782, FGGY_YpCarbK_like, Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases. This subgroup is composed of the uncharacterized Yersinia Pseudotuberculosis carbohydrate kinase that has been named glyerol/xylulose kinase and similar uncharacterized proteins from bacteria and eukaryota. Carbohydrate kinases catalyze the ATP-dependent phosphorylation of their carbohydrate substrate to produce phosphorylated sugar and ADP. The presence of Mg2+ is required for catalytic activity. This subgroup shows high homology to characterized ribulokinases and belongs to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	0
CP036175.1\|QBG07387.1\|1960761_1961703_-\|cytochrome-C-biogenesis-protein-CcdA	gnl\|CDD\|367868	pfam04198, Sugar-bind, Putative sugar-binding domain. This probable domain is found in bacterial transcriptional regulators such as DeoR and SorC. These proteins have an amino-terminal helix-turn-helix pfam00325 that binds to DNA. This domain is probably the ligand regulator binding region. SorC is regulated by sorbose and other members of this family are likely to be regulated by other sugar substrates.	2.26524e-88
CP036175.1\|QBG07388.1\|1961909_1963277_+\|mannitol-dehydrogenase-family-protein	gnl\|CDD\|223324	COG0246, MtlD, Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism].	1.57618e-134
CP036175.1\|QBG07390.1\|1964828_1966106_+\|MFS-transporter	gnl\|CDD\|162096	TIGR00897, Alpha-ketoglutarate_permease, polyol permease family. This family of proteins includes the ribitol and D-arabinitol transporters from Klebsiella pneumoniae and the alpha-ketoglutarate permease from Bacillus subtilis. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
CP036175.1\|QBG07378.1\|1948409_1949303_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|176114	cd08422, PBP2_CrgA_like, The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain. This CD includes the substrate binding domain of LysR-type transcriptional regulator (LTTR) CrgA and its related homologs. The LTTRs are acting as both auto-repressors and activators of target promoters, controlling operons involved in a wide variety of cellular processes such as amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to name a few. In contrast to the tetrameric form of other LTTRs, CrgA from Neisseria meningitides assembles into an octameric ring, which can bind up to four 63-bp DNA oligonucleotides. Phylogenetic cluster analysis further showed that the CrgA-like regulators form a subclass of the LTTRs that function as octamers. The CrgA is an auto-repressor of its own gene and activates the expression of the mdaB gene which coding for an NADPH-quinone reductase and that its action is increased by MBL (alpha-methylene-gamma-butyrolactone), an inducer of NADPH-quinone oxidoreductase. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.29874e-63
CP036175.1\|QBG07380.1\|1950777_1952589_-\|adenine-deaminase	gnl\|CDD\|223933	COG1001, AdeC, Adenine deaminase [Nucleotide transport and metabolism].	1.69561e-180
CP036175.1\|QBG11059.1\|1943878_1945912_-\|methionine--tRNA-ligase	gnl\|CDD\|234655	PRK00133, metG, methionyl-tRNA synthetase; Reviewed.	0
CP036175.1\|QBG07383.1\|1954976_1955777_+\|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase	gnl\|CDD\|180561	PRK06427, PRK06427, bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed.	4.8672e-162
CP036175.1\|QBG07389.1\|1963286_1964750_+\|xylulokinase	gnl\|CDD\|198374	cd07808, FGGY_D-XK_EcXK-like, Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases. This subgroup is predominantly composed of bacterial D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17), which catalyze the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. D-xylulose has been used as a source of carbon and energy by a variety of microorganisms. Some uncharacterized sequences are also included in this subgroup. The prototypical member of this CD is Escherichia coli xylulokinase (EcXK), which exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ is required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	0
CP036175.1\|QBG07377.1\|1947926_1948241_-\|nickel/cobalt-homeostasis-protein-RcnB	gnl\|CDD\|227742	COG5455, COG5455, Predicted integral membrane protein [Function unknown].	1.42959e-21
CP036175.1\|QBG11061.1\|1958739_1959468_-\|SDR-family-oxidoreductase	gnl\|CDD\|226674	COG4221, COG4221, Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only].	2.79873e-75
CP036175.1\|QBG07384.1\|1955925_1956978_+\|class-I-fructose-bisphosphate-aldolase	gnl\|CDD\|236431	PRK09250, PRK09250, class I fructose-bisphosphate aldolase.	0
CP036175.1\|QBG07386.1\|1959745_1960747_+\|LacI-family-DNA-binding-transcriptional-regulator	gnl\|CDD\|380498	cd06274, PBP1_FruR, ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs. Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs, all of which are members of the LacI-GalR family of bacterial transcription regulators. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to members of the type 1 periplasmic binding protein superfamily. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.	2.24647e-104
CP036175.1\|QBG07374.1\|1936255_1939990_-\|DUF4132-domain-containing-protein	gnl\|CDD\|379270	pfam13569, DUF4132, Domain of unknown function (DUF4132). This domain might be involved in the biosynthesis of the molybdopterin cofactor in E.coli.	2.67165e-63
CP036175.1\|QBG07376.1\|1946063_1947173_+\|iron-sulfur-cluster-carrier-protein-ApbC	gnl\|CDD\|183270	PRK11670, PRK11670, iron-sulfur cluster carrier protein ApbC.	0

>CP036175.1|QBG07381.1|1952688_1953636_+|LysR-family-transcriptional-regulator
MLTVDENIMTEPWQRLPALSLKQIQYFVTLAQLRHFTDTANRLAISQPALSSALRQIEAVLGGKLVNRTASSVTLTELGSAILPHSRRVLSVAQLAFQDMQQIVEAGGDGTVRIGLVPSVSSLLFPLLPQTLAQAFPRLRVEFHDQTNDALFCELQSGKIDFAVGAIDRSLPPELLVYPLREDPFVAVLHCDDPLAGQPHVPWKLLAGRDIAVFSKGNIQRLVGALAESHRLTLNTRYQVDYIETLYGLVRSRLAVAILPALYTTHLQDPVLKIAQLQQPALTRTVALMRGPQPLPPLIEACFSLLLSSLREVNL
>CP036175.1|QBG07380.1|1950777_1952589_-|adenine-deaminase
MSSSAETRRRAVQAARGESPFDLLLTDAQIVDMATGEIREADVGIVGEMIASVHPRGSRSDAQEHRSLAGYFLSPGLMDTHVHLESSHLPPERYAEIVLAQGTTAVFWDPHELANVLGVEGVRYAVAASRSLPLQVMVAAPSSVPSTPGLEMSGADFAGAEMATMLAWPEARGVAEVMDMHGVLHGSERMQEIVQAGLDSGKLIEGHARGLSGADLQAYLAAGVTSDHELTSAEDALEKLRAGLTIEIRGSHPYLLPGIVNALKTLPHLSSQITVCTDDVPPDMLLEKGGIIALLNLLIEHGLAATDVLRFATLNAAIRLQRSDLGLIAAGRRADLVAFDSLEQLKAQEVYVAGKLIAREGTLLQPVSAAAGVTPPRNTLQLTPLTPDDFILRVGDIHHGVARLRHIRGARFTQWGEVEVQVRDGKVQIPAGFSLIWVKHRHGRHEAKPQIALLEGWGELRGAIATSYSHDSHNLVVLGRDADDMALAANQLVASGGGMALAQQGKILAHVAMPIAGMLSDLPAPELARQFRELRDLSSKVADWEPPYRVFKAIEGTCLACNAGPHLTDLGLTDGSTRQIVEPLIDCRETPEHIKHNNKHQGA
>CP036175.1|QBG07379.1|1949431_1950775_-|NCS2-family-permease
MADNTLHPSTQGNWLERRFALYSRGSTLRTECLAGITGFLAAAYLLVVIPGLLAVGGMDKGAATTGTILVFVGGTLLMAFYANLPFIVGPGIGGSVLVGVTLAGSEGIGWQVGLGIACWSGILFFLLTKFGLREVVTRSVPQSIKLGLTASIGLFVAVLGFRNAGLVLANAKTNALMLGDFLSPGALVALCGLFLAIALQARKIPGSILWAILVATLIGIPMGVTKLPGSFIDMPHSLTPVLGQIDMLGALNIAFLPFLFVFFASEFFSTMGTTLAVGGEAGLLDEEGNMPHINRPFMVDSIAAAIGPWLGIPAATALIESSAAAEAGGKTGLTALSAAVMFLLMLLFTPVALMIPKEATAPALILIGLNMFSGLRKVDLGNFTDGLPVLMMVMITLIANSFGTGIAGGLLFYVVIKTIAGKWREIPIGLWILAIPLVYYFATLVKH
>CP036175.1|QBG07378.1|1948409_1949303_+|LysR-family-transcriptional-regulator
MFRLEDLALFVRAAALSNFSEAAREAGQQPAQVSAAIKRLETTLNIRLFARSTRSLRLTPEGETWLPYATQMLDTLHAGLQKIQAPDDEIRGTLQIAVPSDLGRNLLLRVFRAFRLRHPALSLRILFSDHRTDVFKDPVDVAFRYGDNDDASFISLPVAPENRRVLVASPGWIAEHGEPQTLDDLTRHNALTYVLRGRPFDRWPLSFGGDVHHVQVSGTIVSDDAEVIRRLAIAGEGIAYKSTLDVSDDIREGRLQVLLPQYQGDVVPLNMICPHRKQLSSAVRLLYEAVKAECEKV
>CP036175.1|QBG07377.1|1947926_1948241_-|nickel/cobalt-homeostasis-protein-RcnB
MRKTKMMLLGVLLACSSGAWAAGGAIQKYELDGVTADFKQFHIGDTVPPLYLTPEYNIKQWQQRNLPAPDAGTHWTYMGGSYVLITDTEGKILKIYDGEIFYHR
>CP036175.1|QBG11060.1|1947552_1947882_+|hypothetical-protein
MNNIALIVKLRELLVIFMHTRSLPEKAADALRYCQENIPLTEVPIGAYGEYYEIFEQITFLSGDQSRTAPDDLLRSGGDLILSILMLYEQIASYIAVEEFMQKQNRFNE
>CP036175.1|QBG07376.1|1946063_1947173_+|iron-sulfur-cluster-carrier-protein-ApbC
MSSQSQAKSPERLRAMVAGTLANFQHPTLKHNLTTLKALHHVAWLDETVHIEIQMPFVWHSAFEVLKEQCSAELLRITGAKAIDWKLTHSIATLQRVKNQPGINGVKNIIAISSGKGGVGKSSTAVNLALALAAEGAKVGILDADIYGPSIPTMLGAEDQRPTSPDGTHMAPIMKFGLATNSIGYLVTDDNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSMHICSNCGHHEPIFGTGGAQKLADKYHTQLLGQLPLHITLREDLDKGTPTVVARPESEFTETYRQLADRVAAQLYWQGEVIPGEIAFRAV
>CP036175.1|QBG11059.1|1943878_1945912_-|methionine--tRNA-ligase
MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFDISYDNYHSTHSDENRELSELIYGRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRESEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDTVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSSFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLSAELADPALYKTFTDAAASIGEAWDSREFGKAIREIMALADVANRYVDEQAPWVVAKQEGRDADLQAICTMGLNMFRVLMTWLKPVLPQLAARAEAFLNSELSWDAIQQPLLGHKVNTFKALYNRIEMKQVEALVEASKEEVKALSAPVTGPLADDPIQETITFDDFAKVDMRIALIENAEFVDGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRLTVMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDSGAQPGQQVK
>CP036175.1|QBG07375.1|1940002_1943740_-|DUF4132-domain-containing-protein
MRSFIYQDEKSHKFWAVEQQGNELHLSWGKVGTSGQSQIKTFADSATAAKAKQKLIGEKTRKGYAENTAAEKHPPQAVASQSNDRPWLADDALIPLTEEIGWFAFHHRNRSRPFNTTPDGNQIWQSITRNDKATFRPSDYHFTSPVWEQAYVELHQRIKHNQSTGSLFSEAALLGQMGYYSDDLIDLFVTQYGLETTVEIACHTLQVTCEYDDDLEKTVVGSDFPVNEIEYLPDWHPRLCHHLSLAPEEEWQRCVQKLIAAIPGLSPSMQPFAALMLPERPDIANEIVLRFAAEEIPAMAWLKMVVDAPSALTTLEKYPLPPLYSHLLPYVATLIANHGMIGVSQLVNDLDEKEASTQLPELEATDYFTKWLAKTNHPDALKILILGAGNKNKRLGYLSKASQKYPHAAIAAYASLLTSDEDPIWRRALTVLISAEPARVEQVLPWIDAHAAETLTTTQSLSDSSAEYASPETLPEILVSPPWLKQNQKSTSPVFKLLVLPVVSTLSLTPAIAEELSGYDYSDYQSQFNYADLPPFESYRWEKVTEPFTPEQNFLWRLGFENWQQLDPGTSQKMPIPQNAITALQCNDYATLINEFHQYTGKRYSQWKLHLLAWMPRGQALALLDALADEPHKGEEGILPIFGIDALPIFVRYLKNDRQSLWPFTPYCGTTDLALPMAQNFSRKKTLREDARSWLLEYPEHAIAGLLPAALGKACKDRDDAQQALRLLADNNHRSLITQIAQRYQQPEIIAALGDFLDVGDFHDFPAKIQPLPEFYQFALWRRPQLKSSGLPLPDDAMRYLGDMLNFPREVKLYAGLNTVKSICTPTSLANFAWDLFNAWIEAGGPSKTNWGFTTLAFFGNDDTARALTPLIRAWPGESQHQRAALGLDILAEIGSDIALMLLNGIAQKIKFAALQENAQNKIQQIAESRGLTIAEMEDRLAPDLALDDSGSLTLDFGPRRFTVSFDEALKPFVRDESHSRLKDLPKPNKSDDETLAAAAVNRYKSLKKDARTVAAQQIMRLESAMCLRRRWTPEQFRQFLVEHPLVRHITRRLVWGVYSEENTLLTCFRVAEDNSYSDAEDNPFSLPEGQIGIPHVLEMAPEDTASFGQLFADYELLPPFRQLDRNHYSLTESECDAMELNRWNGRQCQAGRIVGLERKGWQRIEESGSTSGMYKPSTCGDIVLVTEPFSLLYGETGYDELIPLDMVKIVAEDDIYFGKPAFAFSTLDAIAASELINDIESLFD
>CP036175.1|QBG07374.1|1936255_1939990_-|DUF4132-domain-containing-protein
MKTFIYHDEKSHKFWAVEQQDNELHLSWGKVGTNGQSQIKTFADSVAASKAELKLINEKTKKGYVEDTAAVQPTVASQPSEPAATIAAPQPEHVPTPVDVSRPWLADDAELPLSDELLAQALPSRLFPGEPIAAPEDSELMNLGKEIHKQSGKTVTFNNANCSAYWQQVINEALTDGQLSPAALAVQVAVATRRGWRSGDNPELMDEIVYVYGLEYAVEMFIALQHIEFEYNYQTVQVTFLAEPVSARGAGMFDVRLRAHLALADEPLWQRCVDKLIAALPDMPIGQQPLVALLLPERPDIAHDIARRVMAHKNIRTAEWLKLVARDPQVVKALEPYQAENLFNDYYHGSVWNATVMREQGVAGISRFAPYVHDDLCGELISYVNHPQALTQLIRVSEQGKRCHERMTQACTRFPHAALAALAELLTQKEEKRWRIMLMTQLSARPELVAQIAPWISSQAATLLETCQQKLNQQTDCASDDMLPPVLVSPPWAAKKKKSPIPQLDLSPLALDPVCMLTEEAGKQLLEQRSWYAQQVELSRGKDEKNYLTRLGSFQRWNGNSYDDAPDSVLSAWQRQDYPALIAEFKAHHGSSSREWAVYMLNALPTEQAIVAWNALSKEPHTGAEYVMTYLRLAGLPGFIHSLSRYPQENLSVAIWFAASELAPMVARAFNKLKTVRDAAREWLLAYPEHAITGLLPAAFGKSGEAQDSARQAMRLLVDNGHQPLLEQVAQRYNQPEVMEAVNALLSLDPLDNHPTKIPALPAFYQPAFWTRPQLRENGQALPDAALKSLGEMLRFPVEEGIYPGLQQVKDLCTAESLAAFAWDLFSAWQTAGAPSKESWAFSALGIFGNDDTARALTPLIRVWPGESQHKRATVGLDILAAIGTDIALMQLNGIAQKLKFKALQERAREKIGDIAESRELTVAELEDRLAPDLGLNDDGTLTLDFGPRRFIVSFDEALKPFVRDENGSRLKDLPKPNKSDDDTLATESVNRYKALKKDARTIAAQQIARMESAMCQRRRWTSENFHLFLVSHPLVRHLTRRLVWGVYGADNKLQACFRVAEDNSYSTADDDLFTLPDGEIRIGIPHVLEIPEGDAAAFGQLFADYELLPPFRQLDRNCYTLTPAELSASELTRWAGRKCPSGRVMGLANKGWLRGDPQDGGWIGWMLKPLGQWTLVMEIDEGFAVGMSPDELSAEQLLSKLWLWEGKAHQYGWGNNGPQTATFSVLDSVSASELINDIDALFE
>CP036175.1|QBG07382.1|1954206_1954980_+|hydroxyethylthiazole-kinase
MSDLLNPAHIAHLRHLFRRHSPLVHCMTNDVVQTFTANVLLSIGASPAMVIDPDEASQFAAIADTLLINVGTLTVERAMAMRAAAHSAKQAGKPWVLDPVAVGALTLRTEFCRELLALQPAAIRGNASEIMALAGMSGGGRGVDTTDTAAAALPAAQALARQLNTVVAVTGEVDYITDGQRTRMVTGGDPLMTRVVGTGCALSAVVAASTAMPGDRLENVAAACGLMKLAGGKAAQQGGPGSFTPAFLDALYAEGGL
>CP036175.1|QBG07383.1|1954976_1955777_+|bifunctional-hydroxymethylpyrimidine-kinase/phosphomethylpyrimidine-kinase
MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLARYQIKNVVLDTVMLAKSGDPLLSLSAVQTLRQRLLPQVSLITPNLPEAAALLDAPHARTEQEMLEQGRALLGMGCGAVLMKGGHLDDAESPDWLFTREGEQRFTAPRVQTKNTHGTGCTLSAALAALRPRYDDWGQTVAEAKGWLSAALAQADSLEVGHGIGPVHHFHAWW
>CP036175.1|QBG07384.1|1955925_1956978_+|class-I-fructose-bisphosphate-aldolase
MTDITQLLGKDADTLLQHRCMTIPADQLYLPGSDYVDRVMVDNNRPPAVLRNMQTLYNTGRLAGTGYLSILPVDQGVEHSAGASFAANPLYFDPKNIVELAIEAGCNCVASTYGVLASVSRRYAHRIPFLVKLNHNETLSYPTEYDQTLYASVEQAFNMGAVAVGATIYFGSEQSRRQLEEISVAFERAHELGLVTVLWAYLRNPAFKKDGVDYHVSADLTGQANHLAATIGADIVKQKMAENNGGYKAVNFGYTDDRVYSKLTTENPIDLVRYQLANCYMGRAGLINSGGAAGGETDLSDAVRTAVINKRAGGMGLILGRKAFKKSMADGVKLINAVQDVYLDSKVTIA
>CP036175.1|QBG07385.1|1957102_1958710_-|ribulokinase
MQSNTQNIIGVDVGSGSVRAGVFNLQGELLAHATREITLFRSAGSVVEQSSREIWQAVCYCIKTAVTSAGVAPSSIAGIGFDATCSLVVIGENNAPLAVGPSEDPDRNIIVWMDHRATGQAEKINATGHAVLQYVGGKISPEMETPKILWLKENRPKIYQQARHFFDLADYLTWRSTGDLARSVCTVTCKWTYLAHEKRWDAGYFRQIGLEELADEDFVRIGQRIVDPGTPCEGGLCATAADEMGLPVGTPVAVGMIDAHAGGIGTVGVLNGAVNNMAYVFGTSSCTMTTTQDAVFVPGVWGPYYSAMVPGFWLSEGGQSAAGAAIDQLLSFHPAAAEAKALAKEAGVPLPVYLADKVLAQVDNPSEAVKLAAGLHVVPEFLGNRAPLADPNAKAIIAGLGMERDLENLIALYVAGLCGIGYGLRQIIDAQKNCGIDSENIVISGGAGQHPLVRQLLADACGINVVSTESSEPVLLGSAILGAVAGNIASSLPEAMKQFTRVDKTYRCEEQFSADHQRRYEAYKTLQHTARLIRE
>CP036175.1|QBG11061.1|1958739_1959468_-|SDR-family-oxidoreductase
MNTSLNGKVAAITGAASGIGLECAKTLLGAGAKVVLIDREGEKLNKIVAELGENAFALQVDLMQADQVDNILQGILKLTGRLDIFHANAGAYIGGPVAEGDPDVWDRVLHLNTNAAFRCVRSVLPHLIAQKSGDIIFTSSIAGVVPVIWEPIYTASKFAVQAFVHTTRRQVSQYGVRVGAVLPGPVVTALLDDWPKAKMDEALANGSLMQPIEVAESVLFMVTRSKNVTVRDIVILPNSVDL
>CP036175.1|QBG07386.1|1959745_1960747_+|LacI-family-DNA-binding-transcriptional-regulator
MKKITIYDLAELSGVSASAVSAILNGNWKKRRISAKLAEKVTRIAEEQGYAINRQASMLRSKKSHVIGMIIPKYDNRYFGSVAELFEEMARERGLLPIITCTRRSPELEIEAVKAMLSWQVDWVVATGATNPDKITALCQQAGVPTVNLDLPGSIAPSVISDNYGGAKALTHKILANSVRRRGELAPLTFIGGRSSDHNTSERLRGFHDAHRELGLNVPQANILAPGYSKGKVEACLQERFGSTDIPLQGLFVNSTISLEGVVRWLSQAGLTGSGQPPMGCFDWDPFVYMLGHDIDMVQQDVPAMLEAVFSIIDSGDTNQQRIEIPPLLMSSC
>CP036175.1|QBG07387.1|1960761_1961703_-|cytochrome-C-biogenesis-protein-CcdA
MSKEDDIRLDQKVRAAWMYYIAGQNQSEIASQLGTSRPVVQRLIAAAKEEGIVSISLHHPVANCLDYAQLLQEKYQLIECNIVPAFSEESTLDSVSFGCYQLMARYLQDDKEKIIGLGSGLTLKKTLQRIDFDSLNTRCVALISAMDADGQCNYYDDVPLLLTSKIKAKYYQWPAPRYAQTQEEYDMWCTSRLFRSVCDVARQADVIFVGIGPLGTQSPIFKDGFINQAQMDEVTAQGGIGEIMGRFIDAEGGVVDSEINRMITSYDIRQNQCPRIAVACGEYKRPAILAALKGGWINGLVTDEHTARWLLTR
>CP036175.1|QBG07388.1|1961909_1963277_+|mannitol-dehydrogenase-family-protein
MNNQFTWLHIGLGSFHRAHQAWYLHRLIASGDKRWHIAAGNIRNDAEQVVQALTAQGGRYVLETVSPEGEREYEEITSIQKLLPWQAGLQPLINEGANPQTKVIAFTVTEGGYYLNTSHKLETNNPDLIADLKGDCKTIYGTIARILEKRMADNAGPLTLLNCDNVRHNGERFHDGMVEFLQLTGKQAVIDWMAANTTCPNTMVDRITPRPAADLPARIKAQTGIDDKAPVMGETFIQWVVENNFRDERPNLEAVGVEMVESVIPYEEAKIRILNSSHSCIAWAGTLIGQQYIHESTLTDFIYAIADRYVTEDVIPCLGDNGIDLPTYRDVVLKRFTNPYIQDTNQRVAADGFSKIPAMIAPTLQECYQRGVRPEATAMLPALFFVFMEQWHKGTLPYQYQDGILDAQAVHEMFEASDPVALYARDKALFGALADNADFLALMREKVAAVYSLIK
>CP036175.1|QBG07389.1|1963286_1964750_+|xylulokinase
MYLGIDLGTSEVKALVIDENNEVIASHSAPLSIQRPHPHWSEQSPQSWWEATEYLMTTLREKCAQHWPAIKAIGLSGQMHGAVLLDAAGEVIRPAILWNDTRCAEECAELEEMAPELHQVAGNLAMPGFTAPKLLWVRRHEPQNFKRTATVLLPKDYLRYQMTGKKVSDMSDAAGTLWLDVAKRDWSDSLLDKCGLSRSHMPSLVEGCEVSATLDPQVAKRWGLNASVVVAGGGGDNAVSAIGVGAVSPGDAFISLGTSGVLFVVTDAYRPAPQSAVHAFCHVLPNLWHQMSVMLSAASCLQWFCRLTGTTEVALLEEIAELSAEEKANAPFFLPYLSGERTPHNDPEARGMFWGMTHSSLRAQLGYAVLEGVSFGINDGLRVLKESGTQIDQCSLVGGGARSPFWAQLLADILDMPVVTHKGGETGGALGAARLACLAAGKPIAAVCEKPEVWQTWQADPVRHQTLMQRYVQFNALYLNDLNFRQH
>CP036175.1|QBG07390.1|1964828_1966106_+|MFS-transporter
MSVNNKQWLGLPLNLFWGYIAIAVFMTGDGFELAFLSHYITELGFSPAQASFAFTLYGLAAALSAWISGVVAEIITPLKTMMIGFVLWCVFHVLFLVFGLGHANYPLILLFYGIRGFAYPLFLYSFIVAIIHNVKSDSASSAIGWFWAVYSVGIGVFGSYIPSFTIPHIGELGTLWLALAFCVTGGIIALVSLRNIQTPHHMQNLTTREKFSELGRAATLLYTNRNIMLSSMVRIINTLSLFGFAVIMPMMFVDELGFTTSEWLQVWAVFFFTTIFSNVLWGILGEKLGWMKVVRWFGCVGMALSSLAFYYIPQHFGHNFAMAMIPAIALGIFVAAFVPLAAVFPALEPKHKGAAISVYNLSAGMSNFLAPAIAVILLPFFSTIGVVIAYTALYVVAFFLCAFIRVEQPGFSHKEAPASEQVEFS

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Crispr_ID: CP036175_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP036175_4

2554903-2555003

Orphan

Consensus_repeat	Method
GACCGTTCGGTGGGGAGTCCCGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP036175_4

>merge|CP036175|4|2554903-2555003|CRISPRCasFinder
GACCGTTCGGTGGGGAGTCCCGGGGGCGGCGCGGTGGGACCGCGCTGCCCCCGGGCTACAGGGAGTGTGCTGATTCAGACCGTTCGGTGGGAAGTCCCGGG

>CP036175|4|3|2554903-2555003|CRISPRCasFinder
GACCGTTCGGTGGGGAGTCCCGGG	GGCGGCGCGGTGGGACCGCGCTGCCCCCGGGCTACAGGGAGTGTGCTGATTCA
GACCGTTCGGTGGGAAGTCCCGGG

Protein	Signature genes	Signature genes Name	Protein_function
CP036175.1\|QBG07899.1\|2560532_2561480_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|238566
CP036175.1\|QBG07893.1\|2552074_2553112_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223787
CP036175.1\|QBG07886.1\|2544284_2545043_+\|laccase-domain-containing-protein	unknown	unknown	gnl\|CDD\|319354
CP036175.1\|QBG07889.1\|2547825_2548719_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656
CP036175.1\|QBG07902.1\|2562471_2563239_+\|basic-amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270342
CP036175.1\|QBG07897.1\|2558442_2559468_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223682
CP036175.1\|QBG07891.1\|2549946_2551092_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
CP036175.1\|QBG07890.1\|2548864_2549950_+\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|238527
CP036175.1\|QBG07896.1\|2557624_2558446_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224045
CP036175.1\|QBG11093.1\|2564055_2564778_+\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
CP036175.1\|QBG07898.1\|2559464_2560517_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376439
CP036175.1\|QBG07901.1\|2562344_2562524_-\|hypothetical-protein	unknown	unknown	unknown
CP036175.1\|QBG07903.1\|2563304_2564072_+\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
CP036175.1\|QBG07894.1\|2553092_2554088_+\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223673
CP036175.1\|QBG07900.1\|2561476_2562376_+\|MurR/RpiR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224651
CP036175.1\|QBG07895.1\|2554093_2554870_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213260
CP036175.1\|QBG07887.1\|2545539_2547120_-\|rhodanese-related-sulfurtransferase	unknown	unknown	gnl\|CDD\|238793
CP036175.1\|QBG11092.1\|2555046_2557119_-\|TonB-dependent-siderophore-receptor	unknown	unknown	gnl\|CDD\|273805
CP036175.1\|QBG07892.1\|2551103_2552078_+\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270276
CP036175.1\|QBG07888.1\|2547121_2547718_-\|cysteine-dioxygenase	unknown	unknown	gnl\|CDD\|227840

Protein	Function_ID	Function_description	E-value
CP036175.1\|QBG07899.1\|2560532_2561480_+\|iron-siderophore-ABC-transporter-substrate-binding-protein	gnl\|CDD\|238566	cd01146, FhuD, Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA-like protein is comprised of two globular subdomains connected by a long alpha helix and binds its specific ligands in the cleft between these domains.	9.01008e-44
CP036175.1\|QBG07893.1\|2552074_2553112_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	3.65084e-27
CP036175.1\|QBG07886.1\|2544284_2545043_+\|laccase-domain-containing-protein	gnl\|CDD\|319354	cd16833, YfiH, protein of unknown function YfiH. This subfamily contains YfiH, a protein of unknown function from Shigella flexneri, E. coli, and many similar proteins which collectively are often called DUF152. The structure of YfiH reveals a distant homology to Rho-activating toxins cytotoxic necrotizing factor 1 (CNF1) as well as chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs), all having an invariant Cys-His pair forming a catalytic dyad, and is required by the CNF-1 toxins for deamidation activity.	4.01753e-53
CP036175.1\|QBG07889.1\|2547825_2548719_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.75582e-34
CP036175.1\|QBG07902.1\|2562471_2563239_+\|basic-amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270342	cd13624, PBP2_Arg_Lys_His, Substrate binding domain of the arginine-, lysine-, histidine-binding protein ArtJ; the type 2 periplasmic binding protein fold. This group includes the periplasmic substrate-binding protein ArtJ of the ATP-binding cassette (ABC) transport system from the thermophilic bacterium Geobacillus stearothermophilus, which is specific for arginine, lysine, and histidine. ArtJ belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.66419e-95
CP036175.1\|QBG07897.1\|2558442_2559468_+\|iron-ABC-transporter-permease	gnl\|CDD\|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	4.43693e-72
CP036175.1\|QBG07891.1\|2549946_2551092_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	3.9236e-51
CP036175.1\|QBG07890.1\|2548864_2549950_+\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|238527	cd01094, Alkanesulfonate_monoxygenase, Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin mononucleotide (FMNH2), which is provided by the NADPH-dependent FMN oxidoreductase (SsuE).	7.18982e-92
CP036175.1\|QBG07896.1\|2557624_2558446_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	2.43744e-119
CP036175.1\|QBG11093.1\|2564055_2564778_+\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	1.18539e-153
CP036175.1\|QBG07898.1\|2559464_2560517_+\|iron-ABC-transporter-permease	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	1.26931e-66
CP036175.1\|QBG07903.1\|2563304_2564072_+\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	1.0052e-77
CP036175.1\|QBG07894.1\|2553092_2554088_+\|ABC-transporter-permease-subunit	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	4.25032e-39
CP036175.1\|QBG07900.1\|2561476_2562376_+\|MurR/RpiR-family-transcriptional-regulator	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	8.63909e-49
CP036175.1\|QBG07895.1\|2554093_2554870_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213260	cd03293, ABC_NrtD_SsuB_transporters, ATP-binding cassette domain of the nitrate and sulfonate transporters. NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.	2.01203e-109
CP036175.1\|QBG07887.1\|2545539_2547120_-\|rhodanese-related-sulfurtransferase	gnl\|CDD\|238793	cd01535, 4RHOD_Repeat_4, Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative catalytic Cys residue.	3.48986e-68
CP036175.1\|QBG11092.1\|2555046_2557119_-\|TonB-dependent-siderophore-receptor	gnl\|CDD\|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	2.3863e-103
CP036175.1\|QBG07892.1\|2551103_2552078_+\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270276	cd13558, PBP2_SsuA_like_2, Putative substrate binding domain of sulfonate binding protein, the type 2 periplasmic binding protein fold. This subfamily includes the periplasmic component of putative ABC-type sulfonate transport system similar to SsuA. These domains are found in eubacterial SsuA proteins that serve as initial receptors in the ABC transport of bicarbonate, nitrate, taurine, or a wide range of aliphatic sulfonates, while other closest homologs are involved in thiamine (vitamin B1) biosynthetic pathway and desulfurization (DszB). After binding the ligand, SsuA interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The SsuA proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.35812e-104
CP036175.1\|QBG07888.1\|2547121_2547718_-\|cysteine-dioxygenase	gnl\|CDD\|227840	COG5553, COG5553, Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only].	7.92574e-57

>CP036175.1|QBG07895.1|2554093_2554870_+|ATP-binding-cassette-domain-containing-protein
MLNSQAISTGATVSISHLHHAFTLGKQAVPVLENISLQLRPGESVALLGPSGCGKSTLLRLLAGLEAQQSGQIQIDETAMDGPGPDRILVFQDPTLYPWLTVRQNVLLGPQAQGKKGLEPKADALISRMGLEAFSEAWPRQLSGGMAQRAALARALLNEPRLLLLDEPLGKLDSLTRISMQRELIALWQQQGYTSLLVTHDIEEALLLCERVLVMSPRPGRIIAEFTLPLEFPRHRDNPLLLQHRQDILRILGQEEDW
>CP036175.1|QBG07894.1|2553092_2554088_+|ABC-transporter-permease-subunit
MSTFSPERVLSRPSSGRPLWNEGLLAGVLWLLGGFFTLAWPDVGRRWPFSEGWALAQFTVGGGLLLLALSYRYWRQRGARLQHAGKWLALLPVLFAIWEGLTAKTAFLPVPFFAPPQALIEVLHDDWPRLLDSLLHSLGLLGLGVLLGTSCGFISGLAIGWSQRIGYWVHPVLRLLGPVPSTALLPLCLFIFPSSFGASVFLIALSTWFPVTVLTWSGVIGIDRAWYDVARTLGASQRFLILRVAIPAALPNVFVGLFMGLGASFSVLIVAEMVGVKSGIGFYLQWAQGWAAYPNMYAALLVMALLCSGLISGLFMVRDRLLSWQRGGMKW
>CP036175.1|QBG07893.1|2552074_2553112_+|ABC-transporter-substrate-binding-protein
MMHSGFSRRRFLQLSGGVALAGASLPLWAHDMAAMASSDEPPVLRLAQPYKIKLAINKSAVCLAPVAVAEQQKIFSKYNLDVEFVNFGNSTDVLLEAIATGKADAGVGMALRWLKALEQGFDVKLTAGTHGGCLNLLTAKNSPFGGLESLKGQTIGVTDMAGPDKNFFAILLKRHGIDPISDVQWKVYPADLLSVALDKREIAAISGSEPFSYRLLETGKYQLIASNMTGDYANLSCCVLGVSGTLARDHKPAAAALTQAILEAHSYAAEHPESVAQSFLAHALNTNEAEVSGILHGQGHGHHAVGEAFVKELTQYAVDLQRVQVIKPGTDPHQFAESIYVNVFA
>CP036175.1|QBG07892.1|2551103_2552078_+|ABC-transporter-substrate-binding-protein
MRIPKFTCLAGAVMLLALSGYAAAQERVTLRIADQKGGMRSQLEAANALQNLSYDIKWAEFPAAAPLAEALNAGAVDVGIIGDAPLLFALANGAPVKAIAVDKSNPAGTAVLVSPGSPLKSAADLKGKRIATGKGSIGHFVALKALEQAGISPKEVQWVFLGPVDAKVALLNGSVDAWATWEPYTTQLVKTAEGQILVSGKGLLPGNTFLAATDDALNDPQKRAALQDYLNRLAGAERWAYANLDSYGKTLGEIIRFPADIARAQFANRQSQWLRLDSQTVAQQQATADFYLANGLIRAKLDVTPTFDNGFSVPAAQAHAEVAP
>CP036175.1|QBG07891.1|2549946_2551092_+|acyl-CoA-dehydrogenase
MTDSAFDDWARRLTEIRQLMAEQAASLDASGEFPHHNIERLRQRGFLSLAVPRQYGGAGADLARLQQAIAAIAWGEPATALIVCMQYLHHLRLAENENWAEPLRQQVFQDAVERGGLINSLRVEPELGSPARGGLPKTMASRSAEGWRISGHKIYTTGIEGLSWLALWGRSDDSTPLVGTWLVPRDSDGISMVKSWDHAGMRATGSHEVILKNVQVSAENAVDVWPVDAPPAPDAEQFRLFANRHTALLTAIYDSVARAARDWLVAWLSARIPGNLGHPLSSLPRVQEKVGQIDGLLLVNRSLLEKAAELGFSAIEANLAKVTITDNAIQAVNLALELTGNHGLSRQNPLERHYRNVLCGRVHTPQNDSAWLAAGKYAFQK
>CP036175.1|QBG07890.1|2548864_2549950_+|LLM-class-flavin-dependent-oxidoreductase
MSIQFLGMIGHRLSSETIAPVGPIFDRDYIVRFAQTHEAAGFDRLLVGHWSDQPDGFLVTALAGLSTQNISFLLAHRPGFVSPTLAARKFATLEHLLGGRLAVHIISGGNDAEQRRDGDYLDHDQRYARTDAFLDTLRKVWTAEQPVDIANDFYQAEQAWSAIRPLQKPHIPLYFGGSSEAAIAVAGKHANVFALWGESLAQTDETIRRVRAEAAKHQREIGFSVSFRPIIADTEAEAWEKAEHILHVATERAAQTEGGFKAKPDSVGAQRLRATAAQGKVVDKRLWTGIAQLVGGGHNSTALVGTPEQVADALLDYYDLGVRNFLIRGFDPLNDAQEYGKALLPITREKAALRSVAERAS
>CP036175.1|QBG07889.1|2547825_2548719_+|LysR-family-transcriptional-regulator
MRIDDIDALLATVQFSSLNQAAEYLGITQSAITRRLQRLEQTLNVTLLERQTRPLTLTAAGHRVYEQCLSIKRETKKLYGLLDPEAEPHGILRLGVPQSVAEIALQPALAALRQQFPALQPQVTCGWSGLLQRRLESVELDGVLAMGPEQLSFAEGYSGRLLCPLDIVVIAAKSWRLHAVALRGCAEKGWVLNPDGCGLRAGLIRELHSQGLRLALNVETAGAQLQISLVAQGLGLGLVPRAALAASPWRDEVTVLALADFQPEVHLWLVNAQNLANLSQPLTFFAAKVVQQLNASD
>CP036175.1|QBG07888.1|2547121_2547718_-|cysteine-dioxygenase
MTTPRVEKLRQFIQDVDALHRDFTDEPALLDAVAHRLATLVKKDDWLPEEYTLPHPHHYQQYLLHADSGQRFSIVSFVWGPGQSTPIHDHRVWGAIGMLRGAEENQRYRLDGRGQPVASGLAERLSPGEVEKVSSRDGDIHRVSNALADSVSISIHVYGGNIGGVKRAVYTPEGLVKPFVSGYSNRHLPNIWDLSKDN
>CP036175.1|QBG07887.1|2545539_2547120_-|rhodanese-related-sulfurtransferase
MPTYSYRPTAQLRQALLDGTELALLDVREEAEFARNHPLFAANLPLSKLELDIFRRVPLLTTPITVYDNGEGLAEQAVERLKNWGYQDVALLEGGLQGWQRSGGELFQDVNSPSKAFGELVESKRHTPSLSAEEVKALIDSPQEVVIVDARRFDEYQTMNIPGSISVPGAELALRIEGLLPSPQTTVIVNCAGRTRSIIGTQSLLNAGLPNPVYALRNGTIGWTLAGLELEHGQQRRYDADFHTSAERVAQVKQLAERAGVIFIDTDTVKRWQRQPERTTYLFDVRSPEEYAAGHLPQSVSAPGGQLVQETDHFASVRGARIVLVADDEIRAPITASWLAQMGWEVAVLNDVRRDDFSERGTPAISVPPGPQAEEISPLQLAEQLREPGTVVLDFTTSANYVARHIPGAYWLVRSQLHQALETIPSAKRYVVTCGSSLLARYAVPEVAALTGKPVQLLSGGTLAWISAGLALEHGETHLATPRSDRYRRPYEGTDNSPAAMQAYLDWEFGLVEQLARDGTHGFKVL
>CP036175.1|QBG07886.1|2544284_2545043_+|laccase-domain-containing-protein
MSFTSRLLSDIPGIRYAFLDVHETAAFPYGEMAPVKLVHGNVVHHYQAPQAERPHADAMFTAVRGQKVGVVTADCLPLLMASRDGHYICSVHAGWRGAASGIIENSLALFRRYQVSPEELVVVSGPHIHPCCYEVSSDFYQMLRAMPAGELAKRHRERIFQPHQASSEGARAKATSSDNVWFDLQAFAYLLLRNAGVPDENMEWLGSCTYCTPQSLGSFRRRTHTPAEKSFQYSWIMREPDSDVSMRRNDDC
>CP036175.1|QBG11092.1|2555046_2557119_-|TonB-dependent-siderophore-receptor
MAAENSADKTKKTADETITVVADGAQQNATSGYQPVSTSTATLTSMPMLDIPQVVNTVSDKVLEDQHVTNLDEALYNVANVVQTNTLGGTQDAFSRRGFGSNRDGSIMTNGLRTVLPRSFTAATERVEVLKGPASTLYGILDPGGLINVVTKRPERTFGGSVSATSTSFGGGTGQFDVTGPIEGTQLAYRVIGEYQNEDYWRNFGKEKSSFINPSLTWFGEQATVNVSYSHRNYSTPFDRGTIFDLNTGHAVNVDRKTRFDEPFNITDGYSDLAQLNAEYRLSDAWTARFDYSYSQDHYNDNQARVMAYDSATGDLTRRVDATHGSTQKMHSTRADLQGNVVIGGFYNEILTGLAYENYDLLRTDMIRCKNVKGFNIYNPVYGTVDKCSSVSASDSDQRIQQESYAGYVQDALYLTDKWIAVAGVRYQYYTQYAGKGRPFNVNTDSSDQKWTPKVGLVYKLTPSVSLFGNVAQSFMPQSSIASYIGNLPPEESTSYELGAKFELFNGVTANIALFDIDKRNVLYTEAVGDETIAKTAGKVRSRGVEVDVAGSLTDNLSVIASYGYTDAKVTDDPDYQGKPLPNVPKHTGSLFLSYDIHNVYDSNTLTVGGGGRAVSKRSGTNGADYYLQGYAVADVFAAYKMKLQYPVTLQVNVKNLFDKTYYTSSIGTNNLGNQIGDPREVQFTVKMDF
>CP036175.1|QBG07896.1|2557624_2558446_+|ABC-transporter-ATP-binding-protein
MPQRVLPAEQGIVLDSLSAGYGQTLIVDNIHLTIPHGKMTVLAGANGSGKSTLLSTIARMLKPLGGCVRLDGEVIHQMPTREVSRRLGILPQSPLTPEGLTVFELVSRGRYPWQGLMRQWSDADERAVEEALRLTGTAEFAHLPVDSLSGGQRQRCWIAMALAQQTATILLDEPTTWLDLRYQVDILELLQTLTREHGRTVVTVLHDLNFAVNYADTLVFLKKGQIAGVISEEDVCTPELIKTVFDVDVQMSFNPQTDKPFFMPFRVREESAL
>CP036175.1|QBG07897.1|2558442_2559468_+|iron-ABC-transporter-permease
MSASALLLHRRQSRPRLALVLLSLLLLGGSLVHLGLGARWIAPQTVIQALFHYDPRNFDHRIIVDLRLVRLAAALLTGAALGVAGLLLQTVIRNPLGEPHILGLNAGASLAVVATSALGISLGGVALARPLTAACGAALLFGGVMLLSSSGRGGVTPLRITLCGVALSAFASAVTAAILILDEQTLLAMRTWLAGDLAGLSWQTLRSALLPALAGLTIALVLAPRLNVLALGDKVALGLGVKIVQTRLLGLAAIALLCGSAVAVAGPIGFVGLVVPHVVRRLVTEDIRLALPLAAPVGALVLLLADIAARTLVAPQELATGAMTALVGAPVFIFIAARFFK
>CP036175.1|QBG07898.1|2559464_2560517_+|iron-ABC-transporter-permease
MKSAAHRAGFRLFTAGSYRLLLRPVALRIAGVLLLVILLLALFGLTRGSFPMPSGTLFRALLAPENVAEQQRFILFDIRLPRLFMALLCGAMLGLAGAAMQSITRNGLADPGLIGVKEGASIVVLALVLFFPAVGLVWRPLAGMLGGVLVALLVLLLARDCSRPRFILIGIGVSWTLAAAVGIFMTTADVRDVQTAMIWLAGSLHAATWPLLIVAFCWALPGALILFLTARAADAALLGDRTAIGLGVRLQQLTLLRFFAPVLLTSASVSCVGSLGFVGLMAPHMARFLLRGGQVALLSGSALIGALLVLLTDTIGRLAFAPLQIPAGIVIALVGCPFFIVLLWRRRNAL
>CP036175.1|QBG07899.1|2560532_2561480_+|iron-siderophore-ABC-transporter-substrate-binding-protein
MRWFISLLVLMAAVATAADTQTFTDDLGRTVTVPLHPQRIVSMHDLDITIPLIELGVPPVASHGRTRPDGSHFLRSSAQLTGIDFDNSAIQFIGTADIDLEAVAAAKPDLIITENSRHVSVEQLEKIAPTVSIDHLQGSAPRIYSKLAQLTGTQPRLAILERRYQEQIKQLKATVDTQKIVVSVIQANNGKVTVHHSYHALGRVLRDAGFRFPPFIDKISDGQRIDVSAEQLPELDADFVFATWRSDTGGKPQDELQAMEGVMPGWCDFMRACRTGRYILLPREDVISNSFAALTLMVAQVQSHIAGRPLPEGLK
>CP036175.1|QBG07900.1|2561476_2562376_+|MurR/RpiR-family-transcriptional-regulator
MKTAIKRERGRVDLFGERFRARAHQLSPRLRAVVSYINDNREVVLERTAMEIATATNTSDATVVRAIQALGFAGLRELKQTMERWFGPSVTSSEKMLSTVSELSSDINSSIDFVLEGHQRACEVLSRPDNRAAVAQAVALLTDARQVGIFGIGASGILAEYTARLLSRIGLPSYVMNRTGFSLAEQLISLQRGDVLIMMGQKSPHREGMTTLREARRLGIPTILLTQAVDSRFSQEAQVVIDVPRGGDNGRVPLHGTVLVCLEMIVLSVASTAPQKTVKSMKRINELHRAIGKSGGKRS
>CP036175.1|QBG07901.1|2562344_2562524_-|hypothetical-protein
MPISAAIRQHAFIQFLTITTPFYAFILHKNTQSQQSMQPETFPAVNYLLFSFVYRQTYQ
>CP036175.1|QBG07902.1|2562471_2563239_+|basic-amino-acid-ABC-transporter-substrate-binding-protein
MVKNWMKACCLMAALIGTAQAAQQTYVVGSGGTYRPFEFENSQKQLEGFDIDIIKAIAKAEDFDIKLINTPWEGIFATLGTGDRDIIISGITITDKRKQMVDFSAPYFPAEQSIVVPADSKVTSLEALKSEKVGVVNSSTGDIVVSDVLGKNSTSIKRFDNTPLMLQELFEDGVSAAVGDVGVVKYYIKQHPEKQFKLVPDAKFERQYFGIAVAKGNSELQAKINAGLQKIVADGTYAKIYKTWFDENVPTLPAQ
>CP036175.1|QBG07903.1|2563304_2564072_+|amino-acid-ABC-transporter-permease
MTGFRWEIIEEYGPLFMDGALMTIKCTIICVILGTLWGLTLGLGRMAKAEHGVWKYVLRYLVQFPVRFYVSAFRGTPLFVQIMVVHFALVPLFINPRDGLLVTSGMMSADFARELRSNYGAFLSCIVAITLNAGAYVSEIFRAGIQSIDKGQMEASRALGMPWWKTMRQVILPQAFRRILPPLGNNAIAIVKDSSLASAIGLADLAYAARTVSGAYATYWEPYLTISLVYWVITFLLAQLVNRLEKRFGKSDSHS
>CP036175.1|QBG11093.1|2564055_2564778_+|amino-acid-ABC-transporter-ATP-binding-protein
MIRIHNLHKRFGDSHVLRGISCDIKPQEVVCIIGPSGSGKSTFLRCMNALETVSEGEVEVNGFAAHDRATDINKMRESVGMVFQRFNLFPHKTVLENLIMAPMSLRGMARAEAVHLAEELLAKVGLSDKRDAWPSSLSGGQQQRVAIARALAMKPSIMLFDEPTSALDPELVGDVLEVMKNLASEGMTMVIVTHEMGFAREVADRVIFIDQGIIQEEGKPAQIFSAPTNPRTAEFLSKVL

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Crispr_ID: CP036175_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP036175_6

5406456-5406603

Orphan

Consensus_repeat	Method
GGGGGCTTTCCCGGAGGCGGCGCTTGACGCGCCTGTCCGGGCTACCTGAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP036175_6

>merge|CP036175|6|5406456-5406603|CRISPRCasFinder
GGGGGCTTTCCCGGAGGCGGCGCTTGACGCGCCTGTCCGGGCTACCTGACACCAACCTATACAGACCTGTAGCCCGGGTAAGGCATTAGCCGCAACCCGGGGGCTTTCCCGGAGGCGGCGCTTGGCGCGCCTGTCCGGGCTACCTGAC

>CP036175|6|5|5406456-5406603|CRISPRCasFinder
GGGGGCTTTCCCGGAGGCGGCGCTTGACGCGCCTGTCCGGGCTACCTGAC	ACCAACCTATACAGACCTGTAGCCCGGGTAAGGCATTAGCCGCAACCC
GGGGGCTTTCCCGGAGGCGGCGCTTGGCGCGCCTGTCCGGGCTACCTGAC

Protein	Signature genes	Signature genes Name	Protein_function
CP036175.1\|QBG10317.1\|5397795_5400651_+\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582
CP036175.1\|QBG10325.1\|5407441_5408419_+\|aspartate-carbamoyltransferase	unknown	unknown	gnl\|CDD\|223614
CP036175.1\|QBG10319.1\|5402092_5402596_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP036175.1\|QBG10328.1\|5409560_5412269_-\|magnesium-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|236705
CP036175.1\|QBG10324.1\|5406653_5407106_-\|YhcH/YjgK/YiaL-family-protein	unknown	unknown	gnl\|CDD\|225345
CP036175.1\|QBG10326.1\|5408515_5408977_+\|aspartate-carbamoyltransferase-regulatory-subunit	unknown	unknown	gnl\|CDD\|234859
CP036175.1\|QBG10332.1\|5417313_5419488_+\|anaerobic-ribonucleoside-triphosphate-reductase	unknown	unknown	gnl\|CDD\|236436
CP036175.1\|QBG11234.1\|5407285_5407405_+\|PyrBI-operon-leader-peptide	unknown	unknown	gnl\|CDD\|236664
CP036175.1\|QBG10316.1\|5397352_5397796_+\|DNA-polymerase-III-subunit-chi	unknown	unknown	gnl\|CDD\|235581
CP036175.1\|QBG10322.1\|5404757_5405183_-\|ribonuclease-E-inhibitor-RraB	unknown	unknown	gnl\|CDD\|236876
CP036175.1\|QBG10318.1\|5400710_5401907_-\|DUF898-family-protein	unknown	unknown	gnl\|CDD\|226719
CP036175.1\|QBG10327.1\|5409110_5409497_+\|2-iminobutanoate/2-iminopropanoate-deaminase	unknown	unknown	gnl\|CDD\|105214
CP036175.1\|QBG10315.1\|5395773_5397285_+\|leucyl-aminopeptidase	unknown	unknown	gnl\|CDD\|234863
CP036175.1\|QBG10321.1\|5403821_5404580_-\|tRNA-(ms[2]io[6]A)-hydroxylase	unknown	unknown	gnl\|CDD\|114868
CP036175.1\|QBG10331.1\|5415195_5416851_+\|alpha,alpha-phosphotrehalase	unknown	unknown	gnl\|CDD\|182849
CP036175.1\|QBG10330.1\|5413724_5415143_+\|PTS-trehalose-transporter-subunit-IIBC	unknown	unknown	gnl\|CDD\|182896
CP036175.1\|QBG10320.1\|5402757_5403780_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223730
CP036175.1\|QBG10314.1\|5394282_5395380_-\|lipopolysaccharide-ABC-transporter-permease-LptF	unknown	unknown	gnl\|CDD\|185075
CP036175.1\|QBG10329.1\|5412648_5413596_+\|HTH-type-transcriptional-regulator-TreR	unknown	unknown	gnl\|CDD\|181905
CP036175.1\|QBG10323.1\|5405347_5406352_+\|ornithine-carbamoyltransferase	unknown	unknown	gnl\|CDD\|179587

Protein	Function_ID	Function_description	E-value
CP036175.1\|QBG10317.1\|5397795_5400651_+\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
CP036175.1\|QBG10325.1\|5407441_5408419_+\|aspartate-carbamoyltransferase	gnl\|CDD\|223614	COG0540, PyrB, Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism].	4.04595e-165
CP036175.1\|QBG10319.1\|5402092_5402596_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.29857e-18
CP036175.1\|QBG10328.1\|5409560_5412269_-\|magnesium-translocating-P-type-ATPase	gnl\|CDD\|236705	PRK10517, PRK10517, magnesium-transporting P-type ATPase MgtA.	0
CP036175.1\|QBG10324.1\|5406653_5407106_-\|YhcH/YjgK/YiaL-family-protein	gnl\|CDD\|225345	COG2731, EbgC, Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism].	2.90217e-66
CP036175.1\|QBG10326.1\|5408515_5408977_+\|aspartate-carbamoyltransferase-regulatory-subunit	gnl\|CDD\|234859	PRK00893, PRK00893, aspartate carbamoyltransferase regulatory subunit; Reviewed.	8.8229e-85
CP036175.1\|QBG10332.1\|5417313_5419488_+\|anaerobic-ribonucleoside-triphosphate-reductase	gnl\|CDD\|236436	PRK09263, PRK09263, anaerobic ribonucleoside triphosphate reductase; Provisional.	0
CP036175.1\|QBG11234.1\|5407285_5407405_+\|PyrBI-operon-leader-peptide	gnl\|CDD\|236664	PRK10224, PRK10224, pyr operon leader peptide.	2.02519e-08
CP036175.1\|QBG10316.1\|5397352_5397796_+\|DNA-polymerase-III-subunit-chi	gnl\|CDD\|235581	PRK05728, PRK05728, DNA polymerase III subunit chi; Validated.	2.86818e-68
CP036175.1\|QBG10322.1\|5404757_5405183_-\|ribonuclease-E-inhibitor-RraB	gnl\|CDD\|236876	PRK11191, PRK11191, ribonuclease E inhibitor RraB.	4.56454e-63
CP036175.1\|QBG10318.1\|5400710_5401907_-\|DUF898-family-protein	gnl\|CDD\|226719	COG4269, COG4269, Predicted membrane protein [Function unknown].	6.48194e-61
CP036175.1\|QBG10327.1\|5409110_5409497_+\|2-iminobutanoate/2-iminopropanoate-deaminase	gnl\|CDD\|105214	PRK11401, PRK11401, enamine/imine deaminase.	1.37858e-64
CP036175.1\|QBG10315.1\|5395773_5397285_+\|leucyl-aminopeptidase	gnl\|CDD\|234863	PRK00913, PRK00913, multifunctional aminopeptidase A; Provisional.	0
CP036175.1\|QBG10321.1\|5403821_5404580_-\|tRNA-(ms[2]io[6]A)-hydroxylase	gnl\|CDD\|114868	pfam06175, MiaE, tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE). This family consists of several bacterial tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) proteins. The modified nucleoside 2-methylthio-N-6-isopentenyl adenosine (ms2i6A) is present at position 37 (3' of the anticodon) of tRNAs that read codons beginning with U except tRNA(I,V Ser) in Escherichia coli. Salmonella typhimurium 2-methylthio-cis-ribozeatin (ms2io6A) is found in tRNA, probably in the corresponding species that have ms2i6A in E. coli. The miaE gene is absent in E. coli, a finding consistent with the absence of the hydroxylated derivative of ms2i6A in this species.	1.32123e-93
CP036175.1\|QBG10331.1\|5415195_5416851_+\|alpha,alpha-phosphotrehalase	gnl\|CDD\|182849	PRK10933, PRK10933, trehalose-6-phosphate hydrolase; Provisional.	0
CP036175.1\|QBG10330.1\|5413724_5415143_+\|PTS-trehalose-transporter-subunit-IIBC	gnl\|CDD\|182896	PRK11007, PRK11007, PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional.	0
CP036175.1\|QBG10320.1\|5402757_5403780_+\|alpha/beta-hydrolase	gnl\|CDD\|223730	COG0657, Aes, Esterase/lipase [Lipid metabolism].	8.63365e-26
CP036175.1\|QBG10314.1\|5394282_5395380_-\|lipopolysaccharide-ABC-transporter-permease-LptF	gnl\|CDD\|185075	PRK15120, PRK15120, lipopolysaccharide ABC transporter permease LptF; Provisional.	0
CP036175.1\|QBG10329.1\|5412648_5413596_+\|HTH-type-transcriptional-regulator-TreR	gnl\|CDD\|181905	PRK09492, treR, HTH-type transcriptional regulator TreR.	0
CP036175.1\|QBG10323.1\|5405347_5406352_+\|ornithine-carbamoyltransferase	gnl\|CDD\|179587	PRK03515, PRK03515, ornithine carbamoyltransferase subunit I; Provisional.	0

>CP036175.1|QBG10323.1|5405347_5406352_+|ornithine-carbamoyltransferase
MSAFYQKHFLKLLDFTPAEITALLELAARLKADKKNNIEIQHLTGKNIALIFEKDSTRTRCSFEVAAFDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAEFAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLVYAGDARNNMGNSMLEAAALTGLDLRLVAPMACWPEEKLVAQCQALAQKNGGNITLTEDIAAGVKGADFIYTDVWVSMGEAKEKWAERIALLRAYQVNSEMMTLTGNPQVKFLHCLPAFHDDQTTLGKQMAADYGLHGGMEVTDEVFESPASIVFDQAENRMHTIKAVMVATLGK
>CP036175.1|QBG10322.1|5404757_5405183_-|ribonuclease-E-inhibitor-RraB
MANPELLEEQREETRLIIEELLEDGSDPDALYTIEHHLSADDFETLEKVAVEAFKLGYEVTEPEELEVEEGDTVICCDILSESALNAELIDTQVEQLMTLAEKYEVEYDGWGTYYEDPNGEDEEGDDDEDLVDEDDDGVRH
>CP036175.1|QBG10321.1|5403821_5404580_-|tRNA-(ms[2]io[6]A)-hydroxylase
MDYPHILSPILDFLHCPTPQAWIDEARKPENLPLLLTDHMVCELKAAQNAMLLVRRYVADKEGADELLACLKPYEDFTYRWGPEPDFVALHKQINKSAMPQTDDPWGRQLLDSMILLIKEELHHFWQVREIMLSRDIPYVKITASNYARGLRREVRSHEPVMLIDKLICGAYIEARSCERFAALAPWLDDDLQKFYLSLLRSEARHYQDYLDLAQRIAGDDISERVRQLGEAEAALINATEAEFRFHSGVPA
>CP036175.1|QBG10320.1|5402757_5403780_+|alpha/beta-hydrolase
MTKVPFRLIGSLIIGGMASSVYANELPGNTEGAQVIRVEKTQGRIDALNDIVYSQVKSTVAVRQLHMSLLVPRNGNLKPAIVYFPGGGFTSAAWNKFIEMRMALADAGFVVAAAEYRTVPDTFPAPVVDGKAAIRYLREHATEYGIDPSRIGVLGDSAGGYMAQMLALTNDDKSFDRGDNLAQSSNVQAAATLYGISNLLNIGEGFPEPIQKVHQSPAVTEALLVHGSAFRDWPGATIGSDKQKALAASPMGHISGKKPPFLIMHGSADTLVSPLQSKQLYNALKKEGNQADYVLLEGAEHGDDSWYQKPVIERVVNWFKATLGAPKAAAATEKDKNANL
>CP036175.1|QBG10319.1|5402092_5402596_+|GNAT-family-N-acetyltransferase
MNLAATQTFTLRRLSAHDNAAIAAVIRQVSAEYGLTADKGYTVADPNLDELFQLYSQPGSAYWVVEQNGQVVGGGGVAPLTCSEPDICELQKMYFMTSARGQGLAKKLALIALDHAREQGFKRCYLETTAFLKEAVGLYEHLGFEHIDGPLGCTGHVDCEVTMLKTL
>CP036175.1|QBG10318.1|5400710_5401907_-|DUF898-family-protein
MSMISGQQQSHSHHFVFHGQTWPYFVICLVNVILSIITCGIFIPWAWVRSRRYLCENMAVNGTRLGYHGRGITILLSWVLIFVVLMLLGLALAIFYPGSEGLEVLLLLVLLPVMIIKGLGYHAMMTSFGQVRFGLQCHPLRAWWVMLGMPVLIYTLMAVLFSMLGSNLGFYYGVNSMILSIIFLTLLALFIISVTNGVVYSHWLELIGKSASLGKNKFNICISTKRCMVIFLWATVVSLPFVLIFIVFLFSVFSQMITGCMFGLCSENTALLMVLQDLGAVVGGYFFFTIGIVLSTAYAWAALRNHALNNLVLGDGVHFRSTLTFLGLAPRLLGLTFLPLFTLGLAYPWLKIHLMRYIAANTAVIGELDSLDMEPDVASQPAVSDKLCGGIFPMLPFL
>CP036175.1|QBG10317.1|5397795_5400651_+|valine--tRNA-ligase
MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESKESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQAGTDHAGIATQMVVERKIAAEEGKTRHDYGRDAFIDKIWQWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGAKTADGKDYLVVATTRPETVLGDTGVAVNPEDPRYKDLIGKFVILPLVDRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGRRHALPMINILTFDGDIRESAEVYDTKGEESDVYPNDIPAEFQKLERFAARKAVVAAVDALGLLEEVKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENGDIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDNDGNVYVGRTEDEVRQENNLGAEVALRQDEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFIKDENGKPQIPFKTIYMTGLIRDDEGQKMSKSKGNVIDPLDMVDGISLPNLLEKRTGNMMQPQLAEKIAKRTEKQFPDGIEPHGTDALRFTLAALASTGRDINWDMKRLEGYRNFCNKLWNASRFVLMNTEDQDCGFNGGEMTLSLADRWILAEFNQTIKAYREALDNFRFDIAAGILYEFTWNQFCDWYLELTKPVMTGGSESELRGTRNTLVTVLEGLLRLAHPIIPFITETIWQRVKVISGITADTIMLQPFPEYDAAQVDEAALADTEWLKQAIVAVRNIRAEMNIAPGKQLELLLRGCSEAAMRRVNDNRSFLLNLARLESITVLPADDKGPVSVTKIIDGAELLIPMAGLINKEDELARLAKEVTKIEGEIGRIESKLSNEGFVARAPEAVIAKEREKLEGYAQAKAKLIEQQAVIAAL
>CP036175.1|QBG10316.1|5397352_5397796_+|DNA-polymerase-III-subunit-chi
MKNATFYLLDNDTQQDGLSAVEQLVCDIAAERWRSGKRVLIACEDEQQAIRLDEALWARPAESFVPHNLAGEGPRGGAPVEIAWPQKRNSSPRDILISLRLNFADFATAFTEVIDFVPYEDSLKQLARERYKAYRMAGFNLNTATWK
>CP036175.1|QBG10315.1|5395773_5397285_+|leucyl-aminopeptidase
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNILSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADTYSKNVITRVIGEQQMKELGMNSYLAVGNGSQNESLMSVIEYKGNPAEDARPIVLVGKGLTFDSGGISIKPAEGMDEMKYDMCGAAAVYGVMRMVAELQLPLNVVGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPETVIDVATLTGACVIALGHHITGLMSNHNPLAHELIGASELAGDRAWRLPLGDEFQEQLESNFADMANIGGRPGGAITAGCFLSRFARKYNWAHLDIAGTAWRSGKAKGATGRPVALLSQFLLNRAGFNGEE
>CP036175.1|QBG10314.1|5394282_5395380_-|lipopolysaccharide-ABC-transporter-permease-LptF
MIIIRYLVRETLKSQLAILFILLLIFFCQKLVRILGAAVDGDIPTNLVLSLLGLGVPEMAQLILPLSLFLGLLMTLGKLYTESEITVMHACGLSKAVLVKAAMILALFTGIVAAVNVMWAGPWSSRHQDEVLAEAKANPGMAALAQGQFQQASDGSAVLFIENVNGNRFNDVFLAQLRPKGNARPSVVVADTGELSLRKDGSQVVTMNQGTRFEGTAMLRDFRITDFKNYQAVVGHQAVASDPNDTEQMDMRTLWRTDTDRARAELHWRFTLVATVFIMALMVVPLSVVNPRQGRVLSMLPAMLLYLVFFLLQTSIKSSGGKGKMDPMLWMWTVNLLYFALAVLLNLWDTVPMRRFRARFNKGAA
>CP036175.1|QBG10324.1|5406653_5407106_-|YhcH/YjgK/YiaL-family-protein
MIVGNIHHLQSWLPESLREAIDHVKAHVTDATPLGKHDIDGNNLFYLISEDTTEPMADRRAEYHARYLDIQIVLKGQEGMTFSVLPAGAPDTDWLADKDIAFLAEGAQEKTVILNEGDFVVFYPDEVHKPLCAVGAPAKVRKAVVKMLMA
>CP036175.1|QBG11234.1|5407285_5407405_+|PyrBI-operon-leader-peptide
MPGGIMVQCVRHRVLPRLKTDAGLPFFLSVASVFVKPLI
>CP036175.1|QBG10325.1|5407441_5408419_+|aspartate-carbamoyltransferase
MANPLFQKHIISINDLSREDLELVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSFETAMHRLGASVVGFSDSSNTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFSGGIPVLNAGDGANQHPTQTLLDLFTIQETQGRLENLSIAMVGDLKYGRTVHSLTQALAKFNGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSAIEEVMEEVDILYMTRVQKERLDPSEYANVKAQFVLRAADLEGARANMKVLHPLPRIDEITTDVDKTPHAWYFQQAGNGIFARQALLALVLNSDLALHTQNDSSCRKAASE
>CP036175.1|QBG10326.1|5408515_5408977_+|aspartate-carbamoyltransferase-regulatory-subunit
MTHDNKLQVEAIKRGTVIDHIPAQVGFKLLTLFKLTETDQRITIGLNLPSGEMGRKDLIKIENTFLTDEQVNQLSLYAPQATVNRIDDYEVVGKSRPNLPDRINNVLVCPNSNCISHAEPVSSSFAVKKRENDIALKCKYCEKEFSHNVVLAN
>CP036175.1|QBG10327.1|5409110_5409497_+|2-iminobutanoate/2-iminopropanoate-deaminase
MSKTIATENAPAAIGPYVQGVDLGSMIITSGQIPVDPKTGSVAEDVAAQARQSLDNVKAIVEAAGLKVGDIVKTTVFVKDLNDFATVNAAYEAFFTEHNATFPARSCVEVARLPKDVKIEIEAIAIRR
>CP036175.1|QBG10328.1|5409560_5412269_-|magnesium-translocating-P-type-ATPase
MLKNFTRQLFAQLGRHLPRRLVQRDPLPDARNLASAPIPDSLGKQCLNVAAMDENEIWRAFASHPEGLNEGEVTQKIAQYGENQIPAQKPSPWWVHLWSCYRNPFNLLLTVLGIVSYSTEDLFAAAVIALMVGISTLLNFIQEARSTKAADALKAMVSNTATVLRVVNEQGESRWCELPIDQLVPGDIVKLSAGDMIPADLRIIQARDLFVAQASLTGESLPVEKVARTRDPLQANPLECDTLCFMGTNVVSGSAQAMVFATGGGTWFGQLAGRVSEQESEPNAFQKGISRVSMLLIRFMLVMTPIVLLINGYTKGDWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKHLDAIQNFGAMDILCTDKTGTLTQDKIVLENHTDVSGKVSERVLHAAWLNSHYQTGLKNLLDTAVLEGVELESARGLAERWQKVDEIPFDFERRRMSVVVQEQDNVHQLICKGALQEILNVSAQVRYNGEIVPLDDTMLRRIRRVTDTLNRQGLRVVAVATKYLPAREGDYQRADESDLILEGYIAFLDPPKETTAPALKALKASGITVKILTGDSELVAAKVCHEVGLDAGDVVIGSQVEALNDDELAELAKRTTLFARLAPLHKERIVTVLKREGHVVGFMGDGINDAPALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNFGNVFSVLVASAFLPFLPMLPLHLLIQNLLYDVSQVAIPFDNVDDEQIRKPQRWNPADLGRFMVFFGPISSIFDILTFCLMWWVFHANTPEHQTLFQSGWFVVGLLSQTLIVHMIRTRRIPFIQSRAAWPLIVMTLLVMVVGIALPFSPLAGYLQLQALPLSYFPWLIAILAGYMTLTQMVKGFYSRRYGWQ
>CP036175.1|QBG10329.1|5412648_5413596_+|HTH-type-transcriptional-regulator-TreR
MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSERTRERVEAVMQQHGFSPSRSARAMRGQSDKVVAIIVTRLDSLSENLAVQTMLPVFYEQGYDPIMMESQFSTALVEEHLGMLARRNIDGVVLFGFTGIHEEMLTPWRETLVLLARDAPEIASVCYDDDGAITLLMQRLYDRGHRQISFLGVPHSDVTTGQRRHQAYLNFCQKKRLTPLAALPGLGMKQGYENVASVLAADTSALVCATDTLALGASKYLQQQGIDNIQLASVGSTPLMKFLHPEILTVDPGYAESGRQAAQQLIEQIAGNREPRQIVIPSVLN
>CP036175.1|QBG10330.1|5413724_5415143_+|PTS-trehalose-transporter-subunit-IIBC
MSKVNQQDIDKLIELVGGRDNIATVSHCITRLRFVLNNPAIAKPKEIEQLRMVKGCFTNAGQFQVVIGTEVGDYYKALLATTGQASADKEQAKKAARQNMKWHEQLISHFAEIFFPLLPALISGGLILGFRNVIGDLPMSNGQTLAQMHPSLQSIYDFLWLIGEAIFFYLPVGICWSAVKKVGGTPILGIVLGVTLVSPQLMNAYLLGQQVPEVWNFGLFTIEKVGYQAQVIPALLAGLALGFIETRLKRIVPDYLYLVVVPVCSLILAVFLAHAFIGPFGRMIGDGVAWAVRHLLTGSFAPVGAALFGFLYAPLVITGVHQTTLAIDMQMIQSMGGTPVWPLIALSNIAQASAVVGIIIASRKQNEREISVPAAISAYLGVTEPAMYGINLKYRFPMLCAMIGSGLAGLLCGLNGVMANGIGVGGLPGILSIQPTYWQVYALAMAIAVVVPIVLTTVVYQRKFRQGTLQIV
>CP036175.1|QBG10331.1|5415195_5416851_+|alpha,alpha-phosphotrehalase
MNTLPLWWQNGVIYQIYPKSFQDTTGSGTGDLRGVTSRLDYLQKLGVDAIWLTPFYVSPQVDNGYDVANYTAIDPAYGTLDDFDELVAQAKARGMRIVLDMVLNHTSTAHAWFQESLNKESPYRQFYIWRDGEPTTPPNNWRSKFGGNAWQWHAESEQYYLHLFAVEQADLNWENPAVRAELKKVCEFWADRGVDGLRLDVVNLISKDQSFPSDTDGDGRRFYTDGPRAHEFLQEMSRDIFTPRGLMTVGEMSSTSLEHCQQYAALGGGELSMTFNFHHLKVDYPNGEKWTLAHPDYVALKALFNHWQQGMHNRAWNALFWCNHDQPRIVSRFGDEGEYRVPAAKMLAMVLHGMQGTPYIYQGEEIGMTNPHFKNITDYRDVESHNMFIERAAQGQGADELLAILASKSRDNSRTPMQWNSGENGGFSAGEPWIGLCDNYREINAEAALADPESVFYAYQQLIALRKSTSVLTWGNYQDLLPEHPSLWCYRRQWQGQTLVVVANLSREFQHWQPEAIIGDWRVLISNYAEAANRPSDMTLRPFEAVWWLQE
>CP036175.1|QBG10332.1|5417313_5419488_+|anaerobic-ribonucleoside-triphosphate-reductase
MTPHVMKRDGCKVPFKSERINEAILRAAKAAGVDDADYCATVAEVVSQQMQGRAQVDINEIQTAVENQLMSGPYKQLARAYIEYRHDRDSQREKRGRLNQEIRGLVEQTNSALLNENANKDSKVIPTQRDLLAGIVAKHYARQHLLPHDVVMAHERGVIHYHDLDYSPFFPMFNCMLIDLKGMLTQGFKMGNAEIEPPKSISTATAVTAQIIAQVASHIYGGTTINRIDEVLAPFVTESFNKHRKIAEEWQIPDAEGYARSRTEKECYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGTSWESRLIQQSILRNRIAGLGKNRKTAVFPKLVFAIRDGLNHKFGDANYDIKQLALECASKRMYPDILNYDQVVKVTGSFKTPMGCRSFLGVWENEDGEQVHDGRNNLGVISLNLPRIALEAKGDETAFWKLLDERLQLARKALMTRIARLEGVKARVAPILYMEGACGVRLKADDDVSEIFKNGRASISLGYIGIHETINALFGSKHMYDSEALFGSKHMYDSEALREKGVAIVQRLREAVDQWKDETGYGFSLYSTPSENLCDRFCRLDTAEFGVIEGVTDKGYYTNSFHLDVEKKVNPYDKIDFEAPYPPLANGGFICYGEYPNIQHNLRALEDVWDYSYQHVPYYGTNTPIDECYECGFTGEFECTSKGFTCPKCGNHDASRVSVTRRVCGYLGSPDARPFNAGKQEEVKRRVKHLGNGQIG

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Crispr_ID: CP036175_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP036175_7

5783772-5783911

Orphan

Consensus_repeat	Method
TTTCCCGGAGGCGGCGCTTGACGCGCCTTGTCCGGGCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP036175_7

>merge|CP036175|7|5783772-5783911|CRISPRCasFinder
TTTCCCGGAGGCGGCGCTTGACGCGCCTTGTCCGGGCTACTCAACCCCAGACCGCACGGGCCTGTAGCCCCGTGTAAGGCTTCTGCCGCGACCCGGGGAATTTCCCGGAGGCGGCGCTTGACGCGCCTGTCCGGGCTACC

>CP036175|7|6|5783772-5783911|CRISPRCasFinder
TTTCCCGGAGGCGGCGCTTGACGCGCCTTGTCCGGGCTAC	TCAACCCCAGACCGCACGGGCCTGTAGCCCCGTGTAAGGCTTCTGCCGCGACCCGGGGAA
TTTCCCGGAGGCGGCGCTTGACGCGCCTGTCCGGGCTACC

Protein	Signature genes	Signature genes Name	Protein_function
CP036175.1\|QBG11249.1\|5790592_5790997_+\|ASCH-domain-containing-protein	unknown	unknown	gnl\|CDD\|226838
CP036175.1\|QBG10660.1\|5789755_5790583_+\|glyoxylate-bypass-operon-transcriptional-repressor-IclR	unknown	unknown	gnl\|CDD\|183206
CP036175.1\|QBG10653.1\|5777576_5778071_+\|PTS-fructose-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|129933
CP036175.1\|QBG10664.1\|5796068_5796998_-\|homoserine-O-succinyltransferase	unknown	unknown	gnl\|CDD\|235433
CP036175.1\|QBG10666.1\|5802942_5803161_-\|hypothetical-protein	unknown	unknown	unknown
CP036175.1\|QBG10661.1\|5791011_5792754_-\|bifunctional-isocitrate-dehydrogenase-kinase/phosphatase	unknown	unknown	gnl\|CDD\|226945
CP036175.1\|QBG10663.1\|5794206_5795808_-\|malate-synthase-A	unknown	unknown	gnl\|CDD\|236432
CP036175.1\|QBG10656.1\|5780059_5781292_+\|L-sorbose-1-phosphate-reductase	unknown	unknown	gnl\|CDD\|176200
CP036175.1\|QBG10657.1\|5781284_5782094_+\|shikimate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|183587
CP036175.1\|QBG11248.1\|5783067_5783757_+\|dipeptidase-PepE	unknown	unknown	gnl\|CDD\|179990
CP036175.1\|QBG10658.1\|5783981_5785613_-\|Na/Pi-cotransporter-family-protein	unknown	unknown	gnl\|CDD\|224202
CP036175.1\|QBG10665.1\|5797154_5797592_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|182510
CP036175.1\|QBG11247.1\|5782287_5782536_-\|post-segregation-antitoxin-CcdA	unknown	unknown	gnl\|CDD\|377822
CP036175.1\|QBG10652.1\|5777169_5777577_+\|PTS-sorbose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|129904
CP036175.1\|QBG10655.1\|5779067_5779892_+\|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID	unknown	unknown	gnl\|CDD\|129908
CP036175.1\|QBG10651.1\|5776356_5777160_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|180439
CP036175.1\|QBG10654.1\|5778258_5779056_+\|PTS-mannose/fructose/sorbose-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|237895
CP036175.1\|QBG10659.1\|5785877_5789561_-\|methionine-synthase	unknown	unknown	gnl\|CDD\|236539
CP036175.1\|QBG10662.1\|5792808_5794113_-\|isocitrate-lyase	unknown	unknown	gnl\|CDD\|237893
CP036175.1\|QBG10650.1\|5775331_5776285_+\|sugar-binding-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225263

Protein	Function_ID	Function_description	E-value
CP036175.1\|QBG11249.1\|5790592_5790997_+\|ASCH-domain-containing-protein	gnl\|CDD\|226838	COG4405, COG4405, Uncharacterized protein conserved in bacteria [Function unknown].	1.88466e-59
CP036175.1\|QBG10660.1\|5789755_5790583_+\|glyoxylate-bypass-operon-transcriptional-repressor-IclR	gnl\|CDD\|183206	PRK11569, PRK11569, glyoxylate bypass operon transcriptional repressor IclR.	0
CP036175.1\|QBG10653.1\|5777576_5778071_+\|PTS-fructose-transporter-subunit-IIB	gnl\|CDD\|129933	TIGR00854, pts-sorbose, PTS system, mannose/fructose/sorbose family, IIB component. Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families.It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIB components of this family of PTS transporters. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS].	2.31976e-79
CP036175.1\|QBG10664.1\|5796068_5796998_-\|homoserine-O-succinyltransferase	gnl\|CDD\|235433	PRK05368, PRK05368, homoserine O-succinyltransferase; Provisional.	0
CP036175.1\|QBG10661.1\|5791011_5792754_-\|bifunctional-isocitrate-dehydrogenase-kinase/phosphatase	gnl\|CDD\|226945	COG4579, COG4579, Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms].	0
CP036175.1\|QBG10663.1\|5794206_5795808_-\|malate-synthase-A	gnl\|CDD\|236432	PRK09255, PRK09255, malate synthase; Validated.	0
CP036175.1\|QBG10656.1\|5780059_5781292_+\|L-sorbose-1-phosphate-reductase	gnl\|CDD\|176200	cd08238, sorbose_phosphate_red, L-sorbose-1-phosphate reductase. L-sorbose-1-phosphate reductase, a member of the MDR family, catalyzes the NADPH-dependent conversion of l-sorbose 1-phosphate to d-glucitol 6-phosphate in the metabolism of L-sorbose to (also converts d-fructose 1-phosphate to d-mannitol 6-phosphate). The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of an beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.	0
CP036175.1\|QBG10657.1\|5781284_5782094_+\|shikimate-5-dehydrogenase	gnl\|CDD\|183587	PRK12550, PRK12550, shikimate 5-dehydrogenase; Reviewed.	0
CP036175.1\|QBG11248.1\|5783067_5783757_+\|dipeptidase-PepE	gnl\|CDD\|179990	PRK05282, PRK05282, dipeptidase PepE.	4.73047e-141
CP036175.1\|QBG10658.1\|5783981_5785613_-\|Na/Pi-cotransporter-family-protein	gnl\|CDD\|224202	COG1283, NptA, Na+/phosphate symporter [Inorganic ion transport and metabolism].	0
CP036175.1\|QBG10665.1\|5797154_5797592_+\|acetyltransferase	gnl\|CDD\|182510	PRK10514, PRK10514, putative acetyltransferase; Provisional.	8.95595e-102
CP036175.1\|QBG11247.1\|5782287_5782536_-\|post-segregation-antitoxin-CcdA	gnl\|CDD\|377822	pfam07362, CcdA, Post-segregation antitoxin CcdA. This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein.	0.00010007
CP036175.1\|QBG10652.1\|5777169_5777577_+\|PTS-sorbose-transporter-subunit-IIA	gnl\|CDD\|129904	TIGR00824, EIIA-man, PTS system, mannose/fructose/sorbose family, IIA component. Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Man family is unique in several respects among PTS permease families It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IIA components. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS].	1.73222e-48
CP036175.1\|QBG10655.1\|5779067_5779892_+\|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID	gnl\|CDD\|129908	TIGR00828, Mannose-permease_IID_component_Phosphotransferase, PTS system, mannose/fructose/sorbose family, IID component. Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Man family is unique in several respects among PTS permease families.It is the only PTS family in which members possess a IID protein. It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue. Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars. The mannose permease of E. coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine,N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. This family is specific for the IID subunits of this family of PTS transporters. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS].	1.75562e-159
CP036175.1\|QBG10651.1\|5776356_5777160_+\|SDR-family-oxidoreductase	gnl\|CDD\|180439	PRK06171, PRK06171, sorbitol-6-phosphate 2-dehydrogenase; Provisional.	6.98673e-180
CP036175.1\|QBG10654.1\|5778258_5779056_+\|PTS-mannose/fructose/sorbose-transporter-subunit-IIC	gnl\|CDD\|237895	PRK15065, PRK15065, mannose/fructose/sorbose family PTS transporter subunit IIC.	8.18479e-143
CP036175.1\|QBG10659.1\|5785877_5789561_-\|methionine-synthase	gnl\|CDD\|236539	PRK09490, metH, B12-dependent methionine synthase; Provisional.	0
CP036175.1\|QBG10662.1\|5792808_5794113_-\|isocitrate-lyase	gnl\|CDD\|237893	PRK15063, PRK15063, isocitrate lyase; Provisional.	0
CP036175.1\|QBG10650.1\|5775331_5776285_+\|sugar-binding-transcriptional-regulator	gnl\|CDD\|225263	COG2390, DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription].	8.20324e-115

>CP036175.1|QBG11248.1|5783067_5783757_+|dipeptidase-PepE
MELLLLSNSTLPGKAWLEHALPTIAGQLNGRRSAVFIPFAGVTQTWDDYTAKTAAVFGPMGVAVTGIHSVADPVSAIENAEIVIVGGGNTFQLLKECRERGLLAPMVDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALGLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWIQVTQGHATLGGPNPTLVFRAGEEAVTLNAGHRF
>CP036175.1|QBG11247.1|5782287_5782536_-|post-segregation-antitoxin-CcdA
MAQFAEDLRKLVFWGVLPVWKYDKFERKKCYLESLLCKKICEKKGAPAGEASGWQWEHQHSIDTINQWVTENGSFSDFQRSF
>CP036175.1|QBG10657.1|5781284_5782094_+|shikimate-5-dehydrogenase
MINRDTLLCMSLAGRPGNFGTRFHNYLYEKLGLNYIYKAFTTRDIEAAVKGVRALGIRGCAVSMPFKESCMPFLDAIDPSAKVIDSVNTIVNDDGKLTGLNTDYIAVKSLIDSNQLDSSAKVMIQGSGGMGKAVIAAFRDAGFRDVIIAARNRDNGLALAKQYGFQWQPKPEGIPVDILVNVTPLGMAGGAESETLAFSQTMVEQASVVFDVVALPPETPLIKLAQRLDKQVISGAEVIALQAVEQFTLYTGVRPDDALVAEASAFARG
>CP036175.1|QBG10656.1|5780059_5781292_+|L-sorbose-1-phosphate-reductase
MQTTTALRLYGKRDLRLETFELPAMQDDEILARVVTDSLCLSSWKEANQGEDHKKVPDDVATNPIIIGHEFCGEIIAVGKKWQHKFHAGQRYVIQANLQLPDRPDCPGYSFPWIGGEATHVVIPNEVMEQDCLLSWEGDTWFEGSLVEPLSCVIGAFNANYHLQEGTYNHTMGIRPQGRTLILGGTGPMGLLAIDYALHGPINPSLLVVTDTNKPKLSYARQHYPSEPQTLIHYLDGNDASRETLMALTGGHGFDDIFVFVPNEQLITMASSLLAADGCLNFFAGPQDKQFSAPVNFYDVHYAFTHYVGTSGGNTDDMRAAVALMQAKKVQTAKVVTHILGLNAAGDTTLDLPAVGGGKKLVYTGKNIPLTALGEISDPHLAAIMERNHGIWSKEAEEYLLAHAEDITHD
>CP036175.1|QBG10655.1|5779067_5779892_+|PTS-system-mannose/fructose/sorbose-family-transporter-subunit-IID
MEQRKITQGDLVSMFLRSNLQQASFNFERIHGLGFCYDMIPAIKRLYPLKEDQVAALKRHLVFFNTTPAVCGPVIGVTVAMEEARANGAAIDDGAINGIKVGLMGPLAGVGDPLVWGTLRPITAALGASLALSGNILGPLLFFFIFNAVRLAMKWYGLQLGFRKGVNIVSDMGGNLLQKLTEGASILGLFVMGVLVTKWTTINVPLVVSQTPGADGSTVTMTVQNILDQLCPGLLALGLTLLMVRLLNKKVNPVWLIFALFGLGIIGNALGFLS
>CP036175.1|QBG10654.1|5778258_5779056_+|PTS-mannose/fructose/sorbose-transporter-subunit-IIC
MEISTLQIIAIFIFSCIAGMGSVLDEFQTHRPLIACTVIGLILGDLKTGIMLGGTLELIALGWMNVGAAQSPDSALASIISAILVIVGHQSIATGIAIALPVAAAGQVLTVFARTITVVFQHAADKAAEEARFGTIDLLHVSALGVQALRVAIPALVVSLFVSADMVSNMLNAIPEFVTRGLQIAGGFIVVVGYAMVLRMMGVKYLMPFFFLGFLAGGYLDFSLLAFGGVGVIIALIYIQLNPQWRKPEPQAAATSSTALDQLDD
>CP036175.1|QBG10653.1|5777576_5778071_+|PTS-fructose-transporter-subunit-IIB
MNITLARIDDRLIHGQVTTVWSKVANAQRIIICNDDVYNDEVRRTLLRQAAPPGMKVNVVNLEKAVAVYHNPQYKDETVFYLFTNPQDVLTMVQQGVKIATLNIGGMAWRPGKKQLTKAVSLDEADINAFQQLDKLGVKLDLRVVASDPSVNILDKIAEQSVTE
>CP036175.1|QBG10652.1|5777169_5777577_+|PTS-sorbose-transporter-subunit-IIA
MVNVIFCAHGQLACAMLDSVRMVYGDVNVNAVEFVPGENAGDIATKIEKLVSTHSDEQWLIAVDLQCGSPWNAAAGLAMSNPQLRVISGLSLPLALELVDNQQTMNADELCQHLETIASQCCVTWRQPETVEEDF
>CP036175.1|QBG10651.1|5776356_5777160_+|SDR-family-oxidoreductase
METWLNLKGKIIIVTGGASGIGLAIVDELLAQGANVQMSDIHGGDKHQDSENYTFWPTDISSASEVNKTIDSIIQRFGRIDGLVNNAGVNFPRLLVDEKAPAGRYELNEAAFEKMVNINQKGVFLMSQAVARQMVKQRDGVIVNVSSESGLEGSEGQSCYAATKAALNSFTRSWSKELGKHGIRVVGVAPGILEKTGLRTPEYEEALAWTRSITVEQLREGYTKNSIPIGRSGRLSEVADFVCYLLSERASYITGVTTNIAGGKTRG
>CP036175.1|QBG10650.1|5775331_5776285_+|sugar-binding-transcriptional-regulator
MTMENSDDIRLIVKIAQLYYEQDMTQAQIARELGIYRTTISRLLKRGREQGIVTIAINYDYNENLWLEQQLKQKFGLKEAVVATCDSLLEEDQLNLIGQHGAQLVDRLLEPGDIVGFSWGRAVRALVENLPQASQSRQVICVPIIGGPSGKLESRYHVNTLTYGAAAKLKAESHLADFPALLDNTLIRNGIMQSQHFKTIASYWDNLDVALVGIGSPAIRDGANWHAFYGSEESDDLNARQVAGDICSRFYDIDGGMVETAMSEKTLSIEMAKLKQARYSVGIAMGEEKYSGILGALNGNYINCLVTNKETAESLLK
>CP036175.1|QBG10658.1|5783981_5785613_-|Na/Pi-cotransporter-family-protein
MLTLLHLLSAVALLVWGTHIVRTGVMRVYGARLRSVLSSSVEKKPLAFCAGIGVTALVQSSNATTMLVTSFVSQDLVALAPALVIVLGADVGTALMARVLTFDLSWLSPLLIFIGVIFFLGRKQTRAGQLGRVGIGLGLILLALELIVQAVHPITQANGVQVIFASLTGDIMLDALIGAVFAIISYSSLAAVLLTATLTSTGVISFPVALCLVIGANLGSGLLAMLNNSGANAAARRVALGSLLFKLVGSLIILPFVHVLAEVMHKLPLAEAELVIYFHVFYNLIRCIAMVPFAEPMARLCKRLIRDEPELDARLKPKHLDTSALDTPALALANAARETLRIGDAMEQMLEGLRKIMHGESREEKELRRMADDINVLYTAIKLYLARMPKEELAEEESRRWAEIIEMALNLEQASDIVERMGSEIADKSLAARRAFSMEGLKELDGLYDQLLSNLQLAMSVFFSGDVPSARRLRRSKHRFRILNRRYSHAHVDRLHQQNVQSIETSTLHLALLGDMKRLNSLFCSVAYSVMEQPDEDDERDEY
>CP036175.1|QBG10659.1|5785877_5789561_-|methionine-synthase
MSSKVEQLHQQLKERILVLDGGMGTMIQSYRLSEQDFRGDRFADWPCDLKGNNDLLVLSKPEVITAIHDAYFAAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARASADAWTARTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGSDLILIETVFDTLNAKAAIFAVKEEFEALGVDLPIMISGTITDASGRTLSGQTTEAFYNSLRHADALTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADNMAAQIREWAEAGFLNIVGGCCGTTPEHIAAMSRAVEGLTPRQLPELPVACRLAGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYNEALDVARQQVESGAQIIDINMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVEPFIHHAKKVRRYGAAVVVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLDLAEEYRGSKADESANIQQAEWRSWEVKKRLEYSLVKGITEFIELDTEEARQQAARPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKSARVMKQAVAYLEPYIEASKEKGSSNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAREVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVASLLSDTQHDDFVARTRKEYETVRIQHARKKPRTPPVTLEAARDNDLAFDWENYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGVEAQRLFKDANDLLDKLSAEKALNPRGVVGLFPANRVGDDVEIYRDETRTHVLNVGRHLRQQTEKVGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAYEAQHDDYNKIMVKAIADRLAEAFAEYLHERVRKVYWGYAANENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYFAVAQIQRDQVEDYALRKGMSVAEVERWLAPNLGYDAD
>CP036175.1|QBG10660.1|5789755_5790583_+|glyoxylate-bypass-operon-transcriptional-repressor-IclR
MATPVPAKRGRKPASPAATPAGGQVQSLTRGLKLLEWISESHGSVALTELAQQAGLPNSTTHRLLTTMQQLGFVRQVGELGHWSVGAHAFVVGSSFLQSRNLLAIVHPILRQLMEDSGETVNLAVLDQGDHQAIIIDQVQCTQLMRMSAPIGGKLPMHASGAGKAFLSQLSEEQVTSLLHRKGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCVASCIYDEHHEPFAAISISGPISRITDDRVTELGALAIKAAKEVTLAYGGVR
>CP036175.1|QBG11249.1|5790592_5790997_+|ASCH-domain-containing-protein
MKSYWQDKYPSAFCWSFGDSPELADELAALVVAGKKRGTCGSLASYQQELLPVTPGAYHIVLDGKGKAVCVIRTLALRLIRFNEMNAELAALEGEGDLSLAYWQSAHQAFFEREGTWAPDMELVYEEFAVIEVA
>CP036175.1|QBG10661.1|5791011_5792754_-|bifunctional-isocitrate-dehydrogenase-kinase/phosphatase
MTRGLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKQRIHLYDHHVGLVVEQLRCITDGKNTDADFLLRVKEHYTHLLPDYPRFEIAESFFNSVYCRLFDHRSLTPERLFIFSSQPERRLRSIPRPLAKDFFPDRGWDTLLRKVLSDLPLRLPWQNRVRDIGYINVCLQEALGCELLSRSYLQVANELFYRNKAAWLVGKLVTPMATLPFLLPIHRTDEGELFVDACLTTHAEASIVFGFARSYFMVYAPLPGALVEWLRDILPGKTTAELYMAIGCQKHAKTESYREYLHYISRSDEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDNFAPQKEMTAAHVRACYQLVKEHDRVGRMADTQEFENFVLEKRQIAPELMALLQTEAGAKITDLGERIIISHLYIERRMVPLNIWLEQVDGQALRDAVEEYGNAIRQLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNFREIPPARYPEDELASEPWYSVSPGDVFPEEFRHWLCADRRIGPLFEEMHADLLRADYWRALQTRIREGHVEDVYAYRRRQRFCVRYDNLQQAG
>CP036175.1|QBG10662.1|5792808_5794113_-|isocitrate-lyase
MTTRTQQIEELNKEWTNPRWEGITRPYSAEDVVKLRGSVNPECTLAQLGAAKMWRLLHGEAKKGYINSLGALTGGQALQQAKAGIEAIYLSGWQVAADANLASSMYPDQSLYPANSVPAVVDRINNTFRRADQIQWSAGIEPNDPRYTDYFLPIVADAEAGFGGVLNAFELMKSMIEAGAAAVHFEDQLASVKKCGHMGGKVLVPTQEAIQKLVAARLAADVMGVPTLVIARTDADAADLITSDCDPYDREFITGDRTSEGFFRTHAGIEQAISRGLAYAPYADLVWCETSTPDLELAKRFADAIHAKYPGKLLAYNCSPSFNWQKKLDDKTIASFQQQLADMGYKYQFITLAGIHSMWFNMFDLAHAYAQGEGMKHYVEKVQQPEFAAAKDGYTFVSHQQEVGTGYFDKVTTIIQGGASSVTALTGSTEEEQF
>CP036175.1|QBG10663.1|5794206_5795808_-|malate-synthase-A
MTQQATITDELAFSQPYGEQEKQILTPEAVEFLTELVSRFTPERNKLLAARIQQQQEIDNGKLPDFISETDSIRNGEWKIRGIPEDLQDRRVEITGPVERKMVINALNANVKVFMADFEDSLAPEWSKVIDGQINLRDAVNGTISYTNEAGKIYQLKPDPALLICRVRGLHLPEKHVTWRREAIPGSLFDFALYFFHNYKALLAKGSGPYFYLPKTQAWQEAAWWSEVFSFTEDRFELPRGTIKATLLIETLPAVFQMDEILHALRDHIVGLNCGRWDYIFSYIKTLKNHPDRVLPDRQVVTMDKPFLSAYSRLLIKTCHKRGAFAMGGMAAFIPSKDAERNNQVLNKVKADKSLEANNGHDGTWIAHPGLADTAMAVFNGVLGENKNQLFVTRDDDAPITAEQLLAPCEGERTEEGMRANIRVAVQYIEAWISGNGCVPIYGLMEDAATAEISRTSIWQWIHHEKTLSNGKPVTKALFRQWLAEEMRVIQDELGEHRYSSGRFDEAARLMEQITTSDELIDFLTLPGYRLLA
>CP036175.1|QBG10664.1|5796068_5796998_-|homoserine-O-succinyltransferase
MPIRVQDELPAVNFLRNENVFVMTTTRATTQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQLDIQLLRIDARESRNTPAEHLNNFYCNFEDICDQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWAKDHVTSTLFVCWAVQAALNILYGIPKQTRSEKISGVYEHHILQPHALLTRGFDDSFLAPHSRYADFPAVLIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDANTLASEFFRDVEAGLDPQIPHNYFPQNDPQNKPRASWRSHGNLLFINWLNYYVYQITPYDLRHMNPTLD
>CP036175.1|QBG10665.1|5797154_5797592_+|acetyltransferase
MVISIRRSRHDEGEKLIAIWCRSVDATHDFLSKEYRAELEELVSSFLPEAPLWVAVTEEDEPVAFMLLTGEHMDALFVDPDVRGFGVGKLLINHALTLSSKLTTNVNEQNEQAVGFYKKMGFKVTGRSDTDDLGKPYPLLNLVHE
>CP036175.1|QBG10666.1|5802942_5803161_-|hypothetical-protein
MFLLFALNCCLYRGARWPQYKVIVRGLWIILCVTGYKAGFCWGMQQSVIFLQFNYCRCSVTPYNAPPSTRRM

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP036175_1	1.2\|729728\|61\|CP036175\|PILER-CR	729728-729788	61	CP036175.1	729473-729533	1	0.984
CP036175_1	1.1\|729598\|66\|CP036175\|PILER-CR	729598-729663	66	CP036175.1	729473-729538	6	0.909

1. spacer 1.2|729728|61|CP036175|PILER-CR matches to position: 729473-729533, mismatch: 1, identity: 0.984

ggtcagcttcctcattcaacaaaaccccgtcagaaatggcggggtttttgctttctggta	CRISPR spacer
ggtcagcttcctcattcaacaaaaccccgtcagaaatggcggggtttttgctttctggta	Protospacer
************************************************************

2. spacer 1.1|729598|66|CP036175|PILER-CR matches to position: 729473-729538, mismatch: 6, identity: 0.909

ggtcagcttcctcattcaacaaaaccccgtcagaaatggcggggtttttgctttctggta	CRISPR spacer
ggtcagcttcctcattcaacaaaaccccgtcagaaatggcggggtttttgctttctggta	Protospacer
************************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP036175_5	5.1\|2645841\|34\|CP036175\|CRISPRCasFinder	2645841-2645874	34	MH178096	Aeromonas phage AsXd-1, complete genome	10853-10886	4	0.882
CP036175_2	2.14\|1211906\|30\|CP036175\|CRT	1211906-1211935	30	NZ_CP025929	Microcystis aeruginosa NIES-2481 plasmid p1, complete sequence	145579-145608	7	0.767
CP036175_2	2.6\|1211726\|31\|CP036175\|CRISPRCasFinder	1211726-1211756	31	MN693758	Marine virus AFVG_250M1033, complete genome	32527-32557	8	0.742
CP036175_5	5.1\|2645841\|34\|CP036175\|CRISPRCasFinder	2645841-2645874	34	MK135468	Klebsiella phage 1 TK-2018, complete genome	7436-7469	10	0.706
CP036175_5	5.1\|2645841\|34\|CP036175\|CRISPRCasFinder	2645841-2645874	34	AJ564013	Bacteriophage PY54 complete genome	31548-31581	12	0.647
CP036175_5	5.1\|2645841\|34\|CP036175\|CRISPRCasFinder	2645841-2645874	34	NC_005069	Yersinia phage PY54, complete genome	31548-31581	12	0.647

1. spacer 5.1|2645841|34|CP036175|CRISPRCasFinder matches to MH178096 (Aeromonas phage AsXd-1, complete genome) position: , mismatch: 4, identity: 0.882

aatcgtgcactacttggtgcagcagattcaccag	CRISPR spacer
aatcgttcactacctggtgcagcagattcacccc	Protospacer
****** ******.******************

2. spacer 2.14|1211906|30|CP036175|CRT matches to NZ_CP025929 (Microcystis aeruginosa NIES-2481 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.767

cgctaattaacctgacgaatataagtactg	CRISPR spacer
agctaatgaacctgaccaatataacgattt	Protospacer
 ****** ******** *******  *.*

3. spacer 2.6|1211726|31|CP036175|CRISPRCasFinder matches to MN693758 (Marine virus AFVG_250M1033, complete genome) position: , mismatch: 8, identity: 0.742

gtttggtttatctggccgcttgtggaggcgt	CRISPR spacer
attgaaaatatctggccgctcgtggaggcgg	Protospacer
.** ..  ************.*********

4. spacer 5.1|2645841|34|CP036175|CRISPRCasFinder matches to MK135468 (Klebsiella phage 1 TK-2018, complete genome) position: , mismatch: 10, identity: 0.706

aatcgtgcactacttggtgcagcagattcaccag	CRISPR spacer
tatgatggactacttggtgcagcaggttcgtacc	Protospacer
 ** .** *****************.***..

5. spacer 5.1|2645841|34|CP036175|CRISPRCasFinder matches to AJ564013 (Bacteriophage PY54 complete genome) position: , mismatch: 12, identity: 0.647

aatcgtgcactacttggtgcagcagattcaccag	CRISPR spacer
ccatttgcactacttgatgcagcacattctgagc	Protospacer
   . ***********.******* ****   .

6. spacer 5.1|2645841|34|CP036175|CRISPRCasFinder matches to NC_005069 (Yersinia phage PY54, complete genome) position: , mismatch: 12, identity: 0.647

aatcgtgcactacttggtgcagcagattcaccag	CRISPR spacer
ccatttgcactacttgatgcagcacattctgagc	Protospacer
   . ***********.******* ****   .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2637055 : 2707252

Klebsiella_phage(47.06%)

capsid,protease,portal,tail,tRNA,holin,head,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBG07964.1\|2637055_2638348_-	DUF3596 domain-containing protein	Q8W658	Enterobacteria_phage	3.6e-170	68.0
QBG07965.1\|2638403_2638637_-	excisionase	A0A286S2A4	Klebsiella_phage	1.6e-39	100.0
QBG07966.1\|2639372_2639597_-	hypothetical protein	A0A286S2B3	Klebsiella_phage	4.0e-24	77.0
QBG07967.1\|2639593_2639719_-	sodium:solute symporter	NA	NA	NA	NA
QBG07968.1\|2639715_2640282_-	hypothetical protein	A0A088C4R7	Shewanella_sp._phage	5.2e-28	39.4
QBG07969.1\|2640278_2641028_-	ORF6N domain-containing protein	A0A1B5FPC0	Escherichia_phage	4.2e-118	84.7
QBG07970.1\|2641030_2641267_-	hypothetical protein	NA	NA	NA	NA
QBG11095.1\|2641279_2641798_-	hypothetical protein	A0A286S1S7	Klebsiella_phage	3.5e-79	79.7
QBG07971.1\|2641841_2642282_-	hypothetical protein	A0A286S1S2	Klebsiella_phage	2.7e-40	59.4
QBG11096.1\|2642459_2642747_-	hypothetical protein	NA	NA	NA	NA
QBG07972.1\|2642787_2642997_-	hypothetical protein	NA	NA	NA	NA
QBG07973.1\|2643109_2643373_-	hypothetical protein	NA	NA	NA	NA
QBG11097.1\|2643435_2643624_-	hypothetical protein	NA	NA	NA	NA
QBG07974.1\|2643631_2643838_-	hypothetical protein	NA	NA	NA	NA
QBG07975.1\|2643834_2644038_-	hypothetical protein	NA	NA	NA	NA
QBG07976.1\|2644383_2645091_-	helix-turn-helix transcriptional regulator	Q76H56	Enterobacteria_phage	3.3e-96	74.2
QBG07977.1\|2645204_2645423_+	hypothetical protein	NA	NA	NA	NA
QBG07978.1\|2645546_2646362_+	helix-turn-helix domain-containing protein	A5LH71	Enterobacteria_phage	5.4e-79	60.8
QBG07979.1\|2646377_2647259_+	AAA family ATPase	Q8W641	Enterobacteria_phage	5.5e-77	58.2
QBG07980.1\|2647255_2648611_+	replicative DNA helicase	Q8W640	Enterobacteria_phage	1.2e-160	63.8
QBG07981.1\|2648620_2649436_+	antitermination protein	A0A286N2Q2	Klebsiella_phage	9.5e-100	69.4
QBG07982.1\|2649593_2649863_+	hypothetical protein	A0A286N2Q3	Klebsiella_phage	1.3e-34	84.5
QBG07983.1\|2649768_2650215_-	hypothetical protein	NA	NA	NA	NA
QBG11098.1\|2650912_2651212_+\|holin	holin	A0A286N2Q5	Klebsiella_phage	3.8e-38	82.8
QBG07984.1\|2651208_2651751_+	hypothetical protein	A0A286N2Q6	Klebsiella_phage	1.8e-78	78.1
QBG07985.1\|2651747_2652089_+	hypothetical protein	A0A286N2Q7	Klebsiella_phage	4.5e-43	84.8
QBG07986.1\|2652088_2652358_+	hypothetical protein	G8C7W1	Escherichia_phage	1.5e-22	65.5
QBG11099.1\|2652314_2652509_+	hypothetical protein	A0A286SGR9	Klebsiella_phage	5.1e-20	85.7
QBG07987.1\|2652594_2652780_+	hypothetical protein	NA	NA	NA	NA
QBG07988.1\|2652891_2653137_+	hypothetical protein	NA	NA	NA	NA
QBG07989.1\|2653205_2653406_+	hypothetical protein	A0A1L6Z528	Klebsiella_phage	7.6e-19	73.3
QBG07990.1\|2653591_2653978_+	hypothetical protein	M9NZE9	Enterobacteria_phage	6.0e-20	66.2
QBG07991.1\|2653986_2654328_+	HNH endonuclease	K7P7P4	Enterobacteria_phage	3.3e-46	73.0
QBG07992.1\|2654445_2654910_+\|terminase	phage terminase small subunit P27 family	Q9B019	Phage_GMSE-1	3.7e-48	61.4
QBG07993.1\|2654863_2656606_+\|terminase	terminase large subunit	A0A0U2C138	Paracoccus_phage	2.6e-139	45.6
QBG07994.1\|2656605_2657913_+\|portal	phage portal protein	K7PJU5	Enterobacteria_phage	1.2e-213	84.8
QBG07995.1\|2657925_2658774_+\|protease	Clp protease ClpP	K7PH05	Enterobacteria_phage	7.5e-124	81.1
QBG07996.1\|2658783_2660001_+\|capsid	phage major capsid protein	K7PM57	Enterobacteria_phage	3.6e-196	87.4
QBG07997.1\|2660339_2660666_+\|head,tail	phage gp6-like head-tail connector protein	K7PKT4	Enterobacteria_phage	1.4e-41	71.3
QBG07998.1\|2660736_2660934_+	hypothetical protein	A0A286S2A5	Klebsiella_phage	5.6e-22	87.7
QBG07999.1\|2660935_2661268_+\|head,tail	head-tail adaptor protein	A0A286S2A2	Klebsiella_phage	7.9e-53	90.9
QBG08000.1\|2661260_2661800_+	HK97 gp10 family phage protein	A0A286S249	Klebsiella_phage	8.0e-87	91.6
QBG08001.1\|2661796_2662162_+	DUF3168 domain-containing protein	A0A286S1R1	Klebsiella_phage	3.7e-51	77.7
QBG08002.1\|2662220_2662712_+\|tail	phage tail protein	A0A286S1Q8	Klebsiella_phage	9.5e-79	89.6
QBG08003.1\|2662883_2663438_+	Rha family transcriptional regulator	A0A088CBJ5	Shigella_phage	1.1e-88	87.8
QBG08004.1\|2663497_2663881_+\|tail	phage tail protein	A0A286S1N4	Klebsiella_phage	6.5e-51	82.1
QBG08005.1\|2663883_2664147_+\|tail	phage tail protein	A0A286S1P2	Klebsiella_phage	2.2e-37	86.0
QBG08006.1\|2664299_2664656_+	hypothetical protein	A0A1V0E5P9	Salmonella_phage	2.7e-43	73.3
QBG08007.1\|2664738_2667186_+\|tail	phage tail tape measure protein	A0A286S1S3	Klebsiella_phage	0.0e+00	74.0
QBG08008.1\|2667185_2667665_+	hypothetical protein	A0A286S298	Klebsiella_phage	8.4e-80	82.4
QBG08009.1\|2667651_2668134_+	DUF1833 domain-containing protein	A0A286S2B1	Klebsiella_phage	4.7e-54	67.1
QBG08010.1\|2668141_2668528_+	nitrite transporter	A0A286S2A6	Klebsiella_phage	1.6e-33	51.6
QBG08011.1\|2668524_2671593_+	kinase	A0A286S259	Klebsiella_phage	0.0e+00	68.1
QBG08012.1\|2671668_2673219_+	hypothetical protein	A0A286S1P0	Klebsiella_phage	3.6e-47	84.1
QBG08013.1\|2673237_2673915_+	hypothetical protein	NA	NA	NA	NA
QBG08014.1\|2673907_2675206_+	hypothetical protein	NA	NA	NA	NA
QBG08015.1\|2675386_2675809_+	hypothetical protein	K7P834	Enterobacteria_phage	2.9e-23	45.3
QBG08016.1\|2677008_2678673_-	alpha-glucosidase	NA	NA	NA	NA
QBG08017.1\|2678719_2679718_-	LacI family transcriptional regulator	NA	NA	NA	NA
QBG08018.1\|2679908_2680400_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
QBG08019.1\|2680463_2680841_+	RidA family protein	NA	NA	NA	NA
QBG08020.1\|2681546_2682920_-	MdtK family multidrug efflux MATE transporter	NA	NA	NA	NA
QBG08021.1\|2683151_2683787_+	riboflavin synthase subunit alpha	A0A2I2L4R9	Orpheovirus	5.6e-23	35.8
QBG08022.1\|2683910_2685059_-	cyclopropane fatty acyl phospholipid synthase	A0A2K9L4K8	Tupanvirus	9.3e-85	45.9
QBG08023.1\|2685357_2686551_-	Bcr/CflA family multidrug efflux MFS transporter	NA	NA	NA	NA
QBG08024.1\|2686663_2687575_+	LysR family transcriptional regulator	NA	NA	NA	NA
QBG08025.1\|2687593_2688619_-	HTH-type transcriptional repressor PurR	C6ZCU4	Enterobacteria_phage	1.4e-31	31.9
QBG08026.1\|2688915_2689005_+	YnhF family membrane protein	NA	NA	NA	NA
QBG08027.1\|2689172_2690339_+	MFS transporter	NA	NA	NA	NA
QBG08028.1\|2690416_2690998_-	superoxide dismutase [Fe]	Q56AR7	Bacillus_thuringiensis_phage	1.7e-42	46.5
QBG08029.1\|2691311_2692196_-	peptidoglycan endopeptidase	A0A2H5BM69	Streptomyces_phage	1.8e-19	43.4
QBG08030.1\|2692535_2692883_+	Grx4 family monothiol glutaredoxin	NA	NA	NA	NA
QBG08031.1\|2692937_2693582_-	ribonuclease T	NA	NA	NA	NA
QBG08032.1\|2693693_2694101_-	lactoylglutathione lyase	NA	NA	NA	NA
QBG08033.1\|2694185_2695283_-	alkene reductase	NA	NA	NA	NA
QBG08034.1\|2695336_2695936_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
QBG08035.1\|2696078_2696318_+	DUF1289 domain-containing protein	NA	NA	NA	NA
QBG08036.1\|2696367_2697264_+	aldo/keto reductase family oxidoreductase	A0A1V0SDE7	Indivirus	1.9e-08	29.8
QBG08037.1\|2697327_2699352_-	FUSC family protein	NA	NA	NA	NA
QBG08038.1\|2699351_2700248_-	HlyD family secretion protein	NA	NA	NA	NA
QBG08039.1\|2700258_2700495_-	DUF1656 domain-containing protein	NA	NA	NA	NA
QBG08040.1\|2700665_2701106_+	transcriptional regulator SlyA	NA	NA	NA	NA
QBG08041.1\|2701151_2702504_-	GGDEF domain-containing protein	A0A127AWB9	Bacillus_phage	1.2e-19	38.5
QBG08042.1\|2702736_2703204_-	outer membrane lipoprotein SlyB	NA	NA	NA	NA
QBG08043.1\|2703472_2704597_+	anhydro-N-acetylmuramic acid kinase	NA	NA	NA	NA
QBG11100.1\|2704689_2705013_+	C-type lysozyme inhibitor	NA	NA	NA	NA
QBG11101.1\|2705070_2705727_+	pyridoxamine 5'-phosphate oxidase	NA	NA	NA	NA
QBG08044.1\|2705977_2707252_+\|tRNA	tyrosine--tRNA ligase	K4F5T3	Cronobacter_phage	4.5e-88	42.4

DBSCAN-SWA_2

3280478 : 3284632

Enterobacterial_phage(33.33%)

holin,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBG08555.1\|3280478_3281618_-\|tail	tail fiber domain-containing protein	F9VHK8	Thermus_phage	2.1e-12	41.4
QBG08556.1\|3281885_3282428_-	hypothetical protein	A0A0U2I1S0	Escherichia_phage	1.1e-70	66.5
QBG08557.1\|3282568_3282844_-\|holin	phage holin family protein	K7PKN9	Enterobacterial_phage	3.4e-17	54.2
QBG08558.1\|3282833_3283226_-	hypothetical protein	K7PHB9	Enterobacterial_phage	3.4e-39	71.1
QBG08559.1\|3283303_3283666_-	antitermination protein	A0A0P0ZBT9	Stx2-converting_phage	2.7e-30	55.1
QBG11138.1\|3284095_3284632_-	helix-turn-helix transcriptional regulator	F1C5C2	Cronobacter_phage	3.1e-30	49.0

DBSCAN-SWA_3

4445807 : 4504832

Escherichia_phage(42.86%)

protease,transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBG09517.1\|4445807_4447193_-\|tRNA	cysteine--tRNA ligase	M1PG92	Moumouvirus	1.0e-45	35.1
QBG09518.1\|4447366_4447861_+	peptidylprolyl isomerase B	NA	NA	NA	NA
QBG09519.1\|4447864_4448587_+	UDP-2,3-diacylglucosamine diphosphatase	NA	NA	NA	NA
QBG09520.1\|4448694_4449024_+	hypothetical protein	NA	NA	NA	NA
QBG09521.1\|4449120_4449630_+	5-(carboxyamino)imidazole ribonucleotide mutase	NA	NA	NA	NA
QBG09522.1\|4449626_4450694_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
QBG09523.1\|4450916_4451810_-	carbamate kinase	NA	NA	NA	NA
QBG09524.1\|4451819_4452623_-	DUF2877 domain-containing protein	NA	NA	NA	NA
QBG09525.1\|4452632_4453892_-	DUF1116 domain-containing protein	NA	NA	NA	NA
QBG09526.1\|4453901_4455518_-	acyl-CoA synthetase FdrA	NA	NA	NA	NA
QBG09527.1\|4457162_4458398_+	allantoate amidohydrolase	NA	NA	NA	NA
QBG09528.1\|4458408_4459191_+	(S)-ureidoglycine aminohydrolase	NA	NA	NA	NA
QBG09529.1\|4459791_4460937_-	glycerate 3-kinase	W6LM47	Streptococcus_phage	2.9e-46	39.9
QBG09530.1\|4460959_4462267_-	uracil/xanthine transporter	NA	NA	NA	NA
QBG09531.1\|4462498_4463860_-	allantoinase AllB	NA	NA	NA	NA
QBG09532.1\|4463991_4465446_-	putative allantoin permease	NA	NA	NA	NA
QBG09533.1\|4465656_4466913_-	MFS transporter	NA	NA	NA	NA
QBG09534.1\|4466965_4467844_-	2-hydroxy-3-oxopropionate reductase	NA	NA	NA	NA
QBG09535.1\|4467941_4468718_-	hydroxypyruvate isomerase	NA	NA	NA	NA
QBG09536.1\|4468731_4470513_-	glyoxylate carboligase	E4WLQ6	Ostreococcus_tauri_virus	1.6e-38	27.9
QBG09537.1\|4470601_4471420_-	HTH-type transcriptional repressor AllR	NA	NA	NA	NA
QBG09538.1\|4471511_4471994_-	ureidoglycolate lyase	NA	NA	NA	NA
QBG09539.1\|4472209_4473133_+	HTH-type transcriptional activator AllS	NA	NA	NA	NA
QBG11191.1\|4473220_4474309_+\|tRNA	tRNA 2-selenouridine(34) synthase MnmH	NA	NA	NA	NA
QBG09540.1\|4474372_4475518_-	porin	NA	NA	NA	NA
QBG09541.1\|4475726_4476035_+	monooxygenase	NA	NA	NA	NA
QBG09542.1\|4476106_4478524_-	ABC transporter permease	NA	NA	NA	NA
QBG09543.1\|4478520_4479207_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-32	35.6
QBG09544.1\|4479174_4479801_+\|protease	multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1	NA	NA	NA	NA
QBG09545.1\|4479829_4480600_+	SDR family oxidoreductase	NA	NA	NA	NA
QBG09546.1\|4480784_4481639_+	co-chaperone YbbN	NA	NA	NA	NA
QBG09547.1\|4481980_4482763_-	iron export ABC transporter permease subunit FetB	NA	NA	NA	NA
QBG09548.1\|4482749_4483427_-	iron ABC transporter ATP-binding protein FetA	F2Y165	Organic_Lake_phycodnavirus	5.1e-14	30.4
QBG09549.1\|4483563_4484481_+	SPFH/Band 7/PHB domain protein	NA	NA	NA	NA
QBG09550.1\|4487075_4487999_-\|transposase	IS5 family transposase	Q9MCT5	Escherichia_phage	2.2e-177	99.7
QBG09551.1\|4488078_4488954_-	class A extended-spectrum beta-lactamase CTX-M-14	A0A1B0VBP7	Salmonella_phage	6.1e-153	99.6
QBG09552.1\|4490205_4490994_+	winged helix family transcriptional regulator	NA	NA	NA	NA
QBG09553.1\|4490993_4491512_+	hypothetical protein	NA	NA	NA	NA
QBG09554.1\|4491516_4491933_-	fosfomycin resistance glutathione transferase FosA3	NA	NA	NA	NA
QBG09555.1\|4492318_4493023_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
QBG09556.1\|4493406_4494039_-	type B-3 chloramphenicol O-acetyltransferase CatB3	A0A2R8FE91	Brazilian_cedratvirus	4.1e-26	41.2
QBG11192.1\|4494176_4495007_-	oxacillin-hydrolyzing class D beta-lactamase OXA-1	NA	NA	NA	NA
QBG11193.1\|4495137_4495692_-	fluoroquinolone-acetylating aminoglycoside 6'-N-acetyltransferase AAC(6')-Ib-cr5	NA	NA	NA	NA
QBG09557.1\|4495835_4496540_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
QBG09558.1\|4498756_4499866_-	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	E3SJ82	Synechococcus_phage	2.8e-33	30.2
QBG09559.1\|4499960_4501145_-	tetracycline efflux MFS transporter Tet(D)	NA	NA	NA	NA
QBG09560.1\|4501240_4501897_+	TetR family transcriptional regulator	NA	NA	NA	NA
QBG09561.1\|4501908_4502613_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
QBG09562.1\|4502756_4503398_-	type A-2 chloramphenicol O-acetyltransferase CatII	G3CFL0	Escherichia_phage	7.3e-55	45.9
QBG09563.1\|4503547_4504048_-	hypothetical protein	NA	NA	NA	NA
QBG09564.1\|4504127_4504832_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0

DBSCAN-SWA_4

4509322 : 4549167

Escherichia_phage(25.0%)

integrase,transposase,tRNA

attL 4515877:4515891|attR 4534934:4534948

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBG09569.1\|4509322_4510027_-\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
QBG09570.1\|4510073_4510475_-\|transposase	IS91 family transposase	NA	NA	NA	NA
QBG09571.1\|4510624_4511485_-	class A broad-spectrum beta-lactamase TEM-1	Q1MVP3	Enterobacteria_phage	4.6e-161	100.0
QBG09572.1\|4512305_4513676_-\|transposase	IS1182-like element ISCfr1 family transposase	NA	NA	NA	NA
QBG09573.1\|4513790_4514927_-	DUF3883 domain-containing protein	NA	NA	NA	NA
QBG09574.1\|4514977_4515223_-	hypothetical protein	NA	NA	NA	NA
QBG09575.1\|4515228_4515420_+	hypothetical protein	NA	NA	NA	NA
4515877:4515891	attL	NA	NA	NA	NA
QBG09576.1\|4515901_4516444_-	tunicamycin resistance protein	NA	NA	NA	NA
QBG09577.1\|4516456_4517317_-	aminoglycoside N-acetyltransferase AAC(3)-IId	NA	NA	NA	NA
QBG09578.1\|4517446_4518151_+\|transposase	IS6-like element IS26 family transposase	A0A077SL39	Escherichia_phage	1.8e-139	100.0
QBG09579.1\|4518340_4519030_-\|transposase	IS6 family transposase	A0A077SL39	Escherichia_phage	1.3e-78	67.0
QBG09580.1\|4519117_4519231_+	NTP-binding protein	NA	NA	NA	NA
QBG09581.1\|4519536_4520037_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
QBG09582.1\|4520055_4520235_+	hypothetical protein	NA	NA	NA	NA
QBG09583.1\|4520164_4521004_-	sulfonamide-resistant dihydropteroate synthase Sul1	NA	NA	NA	NA
QBG09584.1\|4520997_4521345_-	quaternary ammonium compound efflux SMR transporter QacE delta 1	NA	NA	NA	NA
QBG11194.1\|4521575_4522220_+	quinolone resistance pentapeptide repeat protein QnrB6	NA	NA	NA	NA
QBG09585.1\|4522311_4523220_-	SDR family oxidoreductase	A0A2N9QUX2	Trichoplusia_ni_ascovirus	5.7e-77	52.4
QBG09586.1\|4523684_4525226_-\|transposase	IS91 family transposase	NA	NA	NA	NA
QBG09587.1\|4525630_4526470_-	sulfonamide-resistant dihydropteroate synthase Sul1	NA	NA	NA	NA
QBG09588.1\|4526463_4526811_-	quaternary ammonium compound efflux SMR transporter QacE delta 1	NA	NA	NA	NA
QBG09589.1\|4526927_4527773_-	ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA16	NA	NA	NA	NA
QBG09590.1\|4527953_4528427_-	trimethoprim-resistant dihydrofolate reductase DfrA27	J9Q7T1	Salmonella_phage	2.4e-10	33.3
QBG09591.1\|4528559_4529012_-	NAD(+)--rifampin ADP-ribosyltransferase Arr-3	NA	NA	NA	NA
QBG09592.1\|4529184_4530198_+\|integrase	class 1 integron integrase IntI1	A0A1P8DJJ6	Virus_Rctr41k	1.0e-71	45.5
QBG09593.1\|4530142_4530466_+\|transposase	transposase	NA	NA	NA	NA
QBG09594.1\|4530503_4531061_+	recombinase family protein	A0A1B0V7I5	Salmonella_phage	5.8e-48	81.3
QBG09595.1\|4531063_4534036_+\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	0.0e+00	73.0
QBG09596.1\|4534638_4536807_+	hypothetical protein	NA	NA	NA	NA
4534934:4534948	attR	NA	NA	NA	NA
QBG09597.1\|4536776_4537493_+	DUF3142 domain-containing protein	NA	NA	NA	NA
QBG09598.1\|4537489_4537900_-	HTH-type transcriptional regulator CueR	NA	NA	NA	NA
QBG09599.1\|4537964_4539134_-	hypothetical protein	A0A1V0SE10	Indivirus	1.2e-05	40.3
QBG09600.1\|4539331_4541833_+	copper-exporting P-type ATPase CopA	A0A218MNH6	uncultured_virus	2.6e-116	39.1
QBG09601.1\|4542011_4543262_-	phospholipase	A0A1B1MR92	Pteropox_virus	1.5e-24	22.2
QBG11195.1\|4543254_4543902_-	MotA/TolQ/ExbB proton channel family protein	NA	NA	NA	NA
QBG09602.1\|4543921_4546162_-	TonB-dependent receptor	NA	NA	NA	NA
QBG09603.1\|4546198_4546960_-	energy transducer TonB	NA	NA	NA	NA
QBG09604.1\|4546961_4547369_-	biopolymer transporter ExbD	NA	NA	NA	NA
QBG09605.1\|4547691_4548486_+	conjugal transfer protein TraB	NA	NA	NA	NA
QBG09606.1\|4548687_4549167_+\|tRNA	Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP036176

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. CP036175

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection