CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP015163	Amycolatopsis albispora strain WP1 chromosome, complete genome	9 crisprs	csa3,WYL,cas3,casR,DEDDh,cas4,DinG,RT	0	6	0	0

Cas Category Instructions

Results visualization

1. CP015163

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CRISPR-Cas detection and classification

Crispr_ID: CP015163_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP015163_1

212701-212791

Orphan

Consensus_repeat	Method
TCCCTGCCGCTGGTGTATTTCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP015163_1

>merge|CP015163|1|212701-212791|CRISPRCasFinder
TCCCTGCCGCTGGTGTATTTCCGGCCGCTGAGAGCCCCGTGCAGGTGTGTATTTCGGTCCCCCTGGTGTCCCTGCCCCTGGTGTATTTCCG

>CP015163|1|1|212701-212791|CRISPRCasFinder
TCCCTGCCGCTGGTGTATTTCCG	GCCGCTGAGAGCCCCGTGCAGGTGTGTATTTCGGTCCCCCTGGTG
TCCCTGCCCCTGGTGTATTTCCG

Protein	Signature genes	Signature genes Name	Protein_function
CP015163.1\|AXB41294.1\|221714_221924_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41284.1\|209828_210254_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41278.1\|207272_208046_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41289.1\|215185_216877_+\|terminase	unknown	unknown	gnl\|CDD\|226974
CP015163.1\|AXB48204.1\|214194_214554_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41283.1\|209572_209836_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41291.1\|218849_219830_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB48203.1\|213515_214184_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238846
CP015163.1\|AXB41288.1\|214767_215226_+\|terminase	unknown	unknown	gnl\|CDD\|377461
CP015163.1\|AXB41293.1\|220612_221602_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379950
CP015163.1\|AXB41292.1\|219920_220562_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41285.1\|210282_210699_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41295.1\|221927_222287_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41280.1\|208484_208664_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41287.1\|211506_212637_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377596
CP015163.1\|AXB41290.1\|216866_217100_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41282.1\|209168_209576_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41279.1\|208104_208485_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB41281.1\|208663_209065_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378935
CP015163.1\|AXB41286.1\|210695_210875_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP015163.1\|AXB41293.1\|220612_221602_+\|hypothetical-protein	gnl\|CDD\|379950	pfam17236, DUF5309, Family of unknown function (DUF5309). This is a family of uncharacterized proteins found in viruses and bacteria.	8.34889e-51
CP015163.1\|AXB41287.1\|211506_212637_+\|hypothetical-protein	gnl\|CDD\|377596	pfam06067, DUF932, Domain of unknown function (DUF932). Family of prokaryotic proteins with unknown function. Contains a number of highly conserved polar residues that could suggest an enzymatic activity.	9.62189e-48
CP015163.1\|AXB41288.1\|214767_215226_+\|terminase	gnl\|CDD\|377461	pfam05119, Terminase_4, Phage terminase, small subunit.	7.90087e-25
CP015163.1\|AXB48203.1\|213515_214184_+\|hypothetical-protein	gnl\|CDD\|238846	cd01713, PAPS_reductase, This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly modified version of the P loop, the fingerprint peptide of mononucleotide-binding proteins, is present in the active site of the protein, which appears to be a positively charged cleft containing a number of conserved arginine and lysine residues. Although PAPS reductase has no ATPase activity, it shows a striking similarity to the structure of the ATP pyrophosphatase (ATP PPase) domain of GMP synthetase, indicating that both enzyme families have evolved from a common ancestral nucleotide-binding fold. The enzyme uses thioredoxin as an electron donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP) . It is also found in NodP nodulation protein P from Rhizobium meliloti which has ATP sulphurylase activity (sulphate adenylate transferase) .	1.55314e-09
CP015163.1\|AXB41281.1\|208663_209065_-\|hypothetical-protein	gnl\|CDD\|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	3.49041e-07
CP015163.1\|AXB41289.1\|215185_216877_+\|terminase	gnl\|CDD\|226974	COG4626, COG4626, Phage terminase-like protein, large subunit [General function prediction only].	1.99689e-85

>CP015163.1|AXB41287.1|211506_212637_+|hypothetical-protein
MAHELELFADGSTAFAAAREPGWHRLGTVAPGPMTAQEVLDLAQLSNWNIRKSLGLTAVVPGEKCQECNRKIGAKHTQKCPVPQEPDRGSDDLMVSEEDTAQLLPVDGWVSTYRTTPVTGELQNLGIVSGEYPIIQPEEFAEFMQTIVDTSGAVFDTGGSLRNGRDIFLTMQLPQAVTIGGVDEIGLFMAGFNNYSGQGKLKVVTTPVRVVCANTERAALRNFRSEYTFRHSKGLQGRIAEAREALKINFEWTEVFKAEAESMINTEMSADTFGDLIKAVWPEKFSKPMDDWKKPEHDHWDSLNGLFKNADTQENIRGTVWAGYNSITEYLDWEIPVPGVGTDAAELARADRAFLGQYNKLKHLAFSKSLDIVAAK
>CP015163.1|AXB41286.1|210695_210875_-|hypothetical-protein
MRIDGTVVFADGRTHLVRIFPGGFHQYAATAEQWRDAEAALKALATAFAAVVNEKDDAR
>CP015163.1|AXB41285.1|210282_210699_-|hypothetical-protein
MSGKLRFGYNKGLPSGVTTAWGCRAIVGDGFGIDVPPDRESGFGDHHTLTGYLRDHCGDAWMAKATAMFEEGEIFVGSDREITLFDDDRAAIKANPRRSYGYLYVCAYFKPRAAERIDDGEGFASLRELLDLGGHDDE
>CP015163.1|AXB41284.1|209828_210254_-|hypothetical-protein
MCSRALDTLTDESGVGYVHPAHVNADHDPAPVEAPDGWRGQCDFCLADNPVAVLPANDFRVPHASTHHSRGDWAACGMCAILIETGRWERLVKRAVRKTADVHRVPVNVTMVVITTGLYEALRKNICGPLRRLDEKAGTDG
>CP015163.1|AXB41283.1|209572_209836_-|hypothetical-protein
MDKTLAIISVNQGDIVQLGFTSNYFHVTDVREPTHPAAPGMVWHGSYFRWAEGCWGEPTLIHMHEGKPMPFVLDQATREMFGWGDLP
>CP015163.1|AXB41282.1|209168_209576_-|hypothetical-protein
MKHSPTHNGCQVFHFAAWRWCIKRAHELLEVHESVATFHEHVLITGMEQFLPLKPAPEGRLKLIEVRVDIEYAMTKTDLSKPIILAPLSSPSGEDFGWMVIDGWHRIYRALSEGRETLPAYLLNPAAEEAIRIPL
>CP015163.1|AXB41281.1|208663_209065_-|hypothetical-protein
MVRDPLIPRLVSVTEAAEIVGCSRQNINNLINSGKLPAGNAGTTLVLAEDTVRRYAAGERFSFPTVLVIDGLDEATDGWVEQFRKAVPPDYEMPERFAPSDLGVAAGEPYRVELLDNQGRTLAVKTVDAEAVN
>CP015163.1|AXB41280.1|208484_208664_-|hypothetical-protein
MTENEKYLALCLVDQIDASAKAIRDLGGDDLAEQVRAFAKDVRHTVATGGSLFNDEVVS
>CP015163.1|AXB41279.1|208104_208485_-|hypothetical-protein
MGFIHEMPPEAGAWQVETRRESFYLHRGETGDLSTFPTTGFSCPEESLPGLVAALKLVMSTKAYQEDARRPVGPCAITLESGRANVHLPVITYGAQLEIRYGEVPILLGRLESLLNGTYGEVVRGL
>CP015163.1|AXB41278.1|207272_208046_+|hypothetical-protein
MLCPGCLAELTAALRELISDGSGGHGLLAELGITLSRQHTMTLGTGVGGHAAERPMPFHEAASEVGWVLANTVSTWAREVHECNPHLLPPAGSTAGAVAWMVGLPGLLALHPAADELHDEITHVVARVRRVVDRPPDRIYAGPCDAQVEGGRCPDHLYARPGQRRVQCGSCGTEHDVDERRNWMISYAADLRVTATVALGWARLLLDKTIPRGTWDSWVSRGRIVPHGTDGRGRPVFRFGDVRDLALAHVSKPRHVA
>CP015163.1|AXB48203.1|213515_214184_+|hypothetical-protein
MREELARKGIPVLLAFSRGKDSLAAWLALRDADVEVRPFHLYLVPGLEFVDESLVDYEKFFGTTIPQLPHPSLFRWLNNLTFQVPERRLIIEAAQLPEPDYVDISRVLCSEYYDLDPEVTFTADGIRAADSPNRRTALKGHGPVREHVMKVSPVWDWRIRHVRAALADHRCPLPVDYELFNRTFDGLDLRFLAPIKERFPRDYERILEWFPLADLELFRAGL
>CP015163.1|AXB48204.1|214194_214554_+|hypothetical-protein
MAQLAGSAAPMGGSNDDLLAQLNAEPEPDPLADVEYTGDVPEDSRRELTALQQGFRDRAKREAERFRLATDSEYWLAICFKSREDKEKFLRNAKLLHVGDKYMDGYAVARLLGVPMDDE
>CP015163.1|AXB41288.1|214767_215226_+|terminase
MGARGAKPKPTALKVLHGDRPDRINHAEPIPPEGEVQPPAELSDDARAVWDRLAPGLITVGVLTSWDIDAFVIVCEALARYRQATKLVNGSALLVQGPNGFVKNPALVVQREAETTFAQYGARFGLTPSDRTQLKVDAPGAAKGPSAERLLS
>CP015163.1|AXB41289.1|215185_216877_+|terminase
MPPRGRAPSASSRKPRLPECGFTLDGRTCRKRGDHFCRPRAAHAVAFCSELCVHTKDKWARRPFELASWQRKDIIEPLFGEVTWDPEWESYVRRYQIGWIELARKNGKSELLAFIALYLLVGDGVEGAEIYGCAMDRGQAAKVFDVAARMVKLSPVLSARLVVKDHIKRIIDERTGSYYEVVAADAAGNLGHNPHGVVFDEVLTQRDARLWDAMRTGMGTRAQPMMIAATTAGDDPASFARSEHDECVRIQDDPDRARHRFAYVRNVPEDADPWDEKNWALANPALGDFLSIRSLRQEAAEARNDPSKENSFRQYRLNQWVQQAHRWMPMHLYRQCAGTVAPAPDWLRAELAGRRAYGGLDLAAKLDMTAWSLLIPDGLDGVPSMLWRFWLPEAAVRFLDGRTNGRVSQWADGGWITVTPGDVIDYDVIYADIAEDCRTFKVMAAGYDEWSGEPVRQEIQKKTRIDLAPIPQTYRGLTFGMTELMALTKSRNWTHHANPVAEWCFDAVAVRHPAGDADQLRPDKPDRQAVGKRIDAVPTAAMAITRWRELAQKHARSGRMVIR
>CP015163.1|AXB41290.1|216866_217100_-|hypothetical-protein
MDWKHLCDMISIDRRKGAGMLGAAQKRLGGQVPFERDQVGDTYRFKMTPEVANTVLALAKKGTDESLDEAGEPPITE
>CP015163.1|AXB41291.1|218849_219830_+|hypothetical-protein
MTVALAPRAGLEHLDATQVVVRRQVDQVQRAWRGLDPGGLRASFTALVGPVMLAAIAAGQVEAAALATPYVNAVLADEPPDAVPPSISASAFAGFTSAGLPLSSLADLLIVRLLTEIGAGMSTTDAMLAGLRRALTYTATEITDAGRTATHVRLIADTRAAGYERVVKLPACDRCIILAGRLYRYSQGFRRHPRCDCTMMPVTRQQWRESNMDNHPRALFDAMSEHEQNVRFGAGNAAAIRAGADLSQVVNARRGALPVAGRWTTTQGTSSRGLAGTRVGELRKQPGRRYRMSQASRPTAGQVINDFSGGTREELTAALRRYGYLL
>CP015163.1|AXB41292.1|219920_220562_+|hypothetical-protein
MSDTTDAPAESGNTDTSTQQTEPEQQPATSSHGQKPEQDEEKDFRKLYEQAVTQSRKWESRARENRDKAKKWDEAEEANRSEAEKSAARAEAAEARAKAAITAAINAEIRAAAHGWATPADAPRYLDEKDRYVTDDGEIDTKAISEDVAAVLKERPHLAAAEGGRRGPNPDPGQGHRGGVSVADQIREAEGKGDHREALRLKTQQLLDRKSGR
>CP015163.1|AXB41293.1|220612_221602_+|hypothetical-protein
MPGIAGMLDTFNSPNFVGELFGVTPTDTPLLSSIGGLTGGQSTDSTIFTWQSYDLRDPDANRQRLEGADAPAPEARKRQNAFNVVEIHQEALSISYTREAANGQFAGTGSAVPTSAGVTGTNPVGDELAWQTQRHLEQIARDIEVSFISGTFAQPTDNTAPRKTRGLLQAIQTNVITHATPTALTEDVVVDLLQETWENGGISVSETATLVCGAHQKRMLTKAFITDKGYREQTRNVGGVQLQTIETDFGRLNIMLNRYMPTDTVVVASLDELAPVFLRIPGRGFLFTEPLAKTGSSDKYQIYGEVGLRYGNERNHGKITGLSTTSEGA
>CP015163.1|AXB41294.1|221714_221924_+|hypothetical-protein
MKFVSEQNPGLVVRDLGVRFVDGEAEVDGKTAAELRKLPPELGVREAGKSDTDESAAGTGAKPRRARPE
>CP015163.1|AXB41295.1|221927_222287_+|hypothetical-protein
MVELFTAATLAALSGRPVSDETAAVIHTWVLAEITGEIGELPDPVPPGVAAVALELGKAAVPAPGGAASTTIGPYSATYASGGPGGTLGRDARMRLRRAVGRNRAFTIETTATSTVDSV

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Crispr_ID: CP015163_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP015163_3

3013085-3013184

Orphan

Consensus_repeat	Method
CGAATGTGGCTTTCGTGACGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP015163_3

>merge|CP015163|3|3013085-3013184|CRISPRCasFinder
CGAATGTGGCTTTCGTGACGCGGTCAGAACAGTGCGAAGCTCCGTTGAGGGTGGCGGTGGGCGACGGGCGGGCGTCTCGAATGTGGCTTTCGTGACGCGG

>CP015163|3|2|3013085-3013184|CRISPRCasFinder
CGAATGTGGCTTTCGTGACGCGG	TCAGAACAGTGCGAAGCTCCGTTGAGGGTGGCGGTGGGCGACGGGCGGGCGTCT
CGAATGTGGCTTTCGTGACGCGG

Protein	Signature genes	Signature genes Name	Protein_function
CP015163.1\|AXB43500.1\|3009189_3010380_+\|acetyl-CoA-acetyltransferase	unknown	unknown	gnl\|CDD\|273881
CP015163.1\|AXB43508.1\|3021987_3023637_+\|acetolactate-synthase	unknown	unknown	gnl\|CDD\|223107
CP015163.1\|AXB43494.1\|3001157_3001586_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379437
CP015163.1\|AXB43507.1\|3021037_3021991_+\|agmatinase	unknown	unknown	gnl\|CDD\|212538
CP015163.1\|AXB43505.1\|3017987_3019484_-\|PucR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|379258
CP015163.1\|AXB43495.1\|3001613_3002222_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379368
CP015163.1\|AXB43506.1\|3019586_3021041_+\|sodium:solute-symporter	unknown	unknown	gnl\|CDD\|271373
CP015163.1\|AXB48475.1\|3006004_3006685_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
CP015163.1\|AXB43509.1\|3023645_3025040_+\|gamma-aminobutyraldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143411
CP015163.1\|AXB43503.1\|3015084_3016113_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377630
CP015163.1\|AXB43497.1\|3003647_3004904_+\|3'-5'-exonuclease	unknown	unknown	gnl\|CDD\|223426
CP015163.1\|AXB43499.1\|3006819_3009072_+\|chitinase	unknown	unknown	gnl\|CDD\|119365
CP015163.1\|AXB43504.1\|3017263_3017935_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|223816
CP015163.1\|AXB43501.1\|3010376_3012485_+\|3-hydroxyacyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|236864
CP015163.1\|AXB43510.1\|3025051_3025477_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB43502.1\|3012566_3012914_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB48476.1\|3013354_3015004_-\|heme-peroxidase	unknown	unknown	gnl\|CDD\|188651
CP015163.1\|AXB43498.1\|3005066_3006008_+\|transposase	unknown	unknown	gnl\|CDD\|366234
CP015163.1\|AXB48477.1\|3016109_3017249_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
CP015163.1\|AXB43496.1\|3002870_3003587_+\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107

Protein	Function_ID	Function_description	E-value
CP015163.1\|AXB43500.1\|3009189_3010380_+\|acetyl-CoA-acetyltransferase	gnl\|CDD\|273881	TIGR01930, 3-ketoacyl-CoA_thiolase, acetyl-CoA acetyltransferases. This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation. [Fatty acid and phospholipid metabolism, Other].	4.47303e-150
CP015163.1\|AXB43508.1\|3021987_3023637_+\|acetolactate-synthase	gnl\|CDD\|223107	COG0028, IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism].	3.02275e-119
CP015163.1\|AXB43494.1\|3001157_3001586_-\|hypothetical-protein	gnl\|CDD\|379437	pfam14042, DUF4247, Domain of unknown function (DUF4247). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 143 and 271 amino acids in length.	6.10239e-17
CP015163.1\|AXB43507.1\|3021037_3021991_+\|agmatinase	gnl\|CDD\|212538	cd11592, Agmatinase_PAH, Agmatinase-like family includes proclavaminic acid amidinohydrolase. This agmatinase subfamily contains bacterial and fungal/metazoan enzymes, including proclavaminic acid amidinohydrolase (PAH, EC 3.5.3.22) and Pseudomonas aeruginosa guanidinobutyrase (GbuA) and guanidinopropionase (GpuA). PAH hydrolyzes amidinoproclavaminate to yield proclavaminate and urea in clavulanic acid biosynthesis. Clavulanic acid is an effective inhibitor of beta-lactamases and is used in combination with amoxicillin to prevent the beta-lactam rings of the antibiotic from hydrolysis and, thus keeping the antibiotic biologically active. GbuA hydrolyzes 4-guanidinobutyrate (4-GB) into 4-aminobutyrate and urea while GpuA hydrolyzes 3-guanidinopropionate (3-GP) into beta-alanine and urea. Mutation studies show that significant variations in two active site loops in these two enzymes may be important for substrate specificity. This subfamily belongs to the ureohydrolase superfamily, which includes arginase, agmatinase, proclavaminate amidinohydrolase, and formiminoglutamase.	7.16663e-166
CP015163.1\|AXB43505.1\|3017987_3019484_-\|PucR-family-transcriptional-regulator	gnl\|CDD\|379258	pfam13556, HTH_30, PucR C-terminal helix-turn-helix domain. This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Bacillus subtilis pucR and is likely to be DNA-binding.	1.08503e-20
CP015163.1\|AXB43495.1\|3001613_3002222_-\|hypothetical-protein	gnl\|CDD\|379368	pfam13785, DUF4178, Domain of unknown function (DUF4178).	5.63633e-33
CP015163.1\|AXB43506.1\|3019586_3021041_+\|sodium:solute-symporter	gnl\|CDD\|271373	cd11479, SLC5sbd_u3, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
CP015163.1\|AXB48475.1\|3006004_3006685_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.21148e-11
CP015163.1\|AXB43509.1\|3023645_3025040_+\|gamma-aminobutyraldehyde-dehydrogenase	gnl\|CDD\|143411	cd07092, ALDH_ABALDH-YdcW, Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like. NAD+-dependent, tetrameric, gamma-aminobutyraldehyde dehydrogenase (ABALDH), YdcW of Escherichia coli K12, catalyzes the oxidation of gamma-aminobutyraldehyde to gamma-aminobutyric acid. ABALDH can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency.	0
CP015163.1\|AXB43503.1\|3015084_3016113_-\|hypothetical-protein	gnl\|CDD\|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	1.3975e-48
CP015163.1\|AXB43497.1\|3003647_3004904_+\|3'-5'-exonuclease	gnl\|CDD\|223426	COG0349, Rnd, Ribonuclease D [Translation, ribosomal structure and biogenesis].	5.10619e-94
CP015163.1\|AXB43499.1\|3006819_3009072_+\|chitinase	gnl\|CDD\|119365	cd06548, GH18_chitinase, The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.	8.28616e-124
CP015163.1\|AXB43504.1\|3017263_3017935_-\|DNA-binding-response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	1.54765e-78
CP015163.1\|AXB43501.1\|3010376_3012485_+\|3-hydroxyacyl-CoA-dehydrogenase	gnl\|CDD\|236864	PRK11154, fadJ, fatty acid oxidation complex subunit alpha FadJ.	3.06777e-119
CP015163.1\|AXB48476.1\|3013354_3015004_-\|heme-peroxidase	gnl\|CDD\|188651	cd09819, An_peroxidase_bacterial_1, Uncharacterized bacterial family of heme peroxidases. Animal heme peroxidases are diverse family of enzymes which are not restricted to metazoans; members are also found in fungi, and plants, and in bacteria - like this family of uncharacterized proteins.	1.32202e-145
CP015163.1\|AXB43498.1\|3005066_3006008_+\|transposase	gnl\|CDD\|366234	pfam00665, rve, Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.	7.57295e-26
CP015163.1\|AXB48477.1\|3016109_3017249_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.27067e-45
CP015163.1\|AXB43496.1\|3002870_3003587_+\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.51418e-57

>CP015163.1|AXB43502.1|3012566_3012914_+|hypothetical-protein
MNVLYSTLVVLHLVGMAGILGGVAGELIAKRTGVPTLVLHSSGLQVLTGAALVGIASSGLVAVEPNNVKVAVKLVIALAVLVVAFEAHKPGKLPKAGLPVVGGLALLNVGVAVYW
>CP015163.1|AXB43501.1|3010376_3012485_+|3-hydroxyacyl-CoA-dehydrogenase
MISAAEAEAAFPDEVVTRAVTRLITVPGLAGQVALITIDNGHDHTRPSTFGPQSLVSLNAAIDEAFAAEPVAIAVTGKPFIFAVGADLSGVEQIAGRDLALQIAQTGHDVFRRLTESKIPTFAFVNGAVMGGGLELALSCHYRTLAENTAAIAFPEVFLGLFPGWGGTQLLPNLIGPDAAVTVIIENALSQNKMLKPAQAAELGIVDELFGSADYLEQSLLWLAKVVRGELTPPRREIDRGAGWDAAIARAKSIVDGKTRGASPGANKAVELLELARANDLDRGYAAETEALADVLMTDTLRAGLYSFNLVNKRAKRPAGAPDKSLARPVNKVGIVGAGLMASQLALLFVRRLKVPVVLTDIDQERVDSGVGYVHGEIDKLLAKKRVSPDAANRLKALVSGSLDKAAFADADFVIEAVFEELGVKQQVFAEVEEHVKPEAILATNTSSLSITEMASKLRHPERVVGFHFFNPVAVLPLLEIVRGERTDDASLATAFAVGKQLKKSSVLVSDAPAFVVNRLLTRFLGEVLAAVDEGTPFEVADRALDPLGLPMSPLTLLQLVGPPVALHVAETMHRAFPDRFGVSQNLAKFVEARKSAVWQWDDKGNATVDPEVVALWEQGDRPSTEEQLRERALSVLAEEVRIMLDEGVVAEAQDIDLCLILGAGWPFWLGGITPYLDRSGVSEKVNGKPFLAPGVASVPTA
>CP015163.1|AXB43500.1|3009189_3010380_+|acetyl-CoA-acetyltransferase
MRNVAFVEGVRTPFGKAGDKGIYAGTRADDLVVKVIRELLRRHPELPPERVDEVAIAATTQTGDQGLTIGRTAALLAGLPKSVPGFAIDRMCAGAMTAVTTTASGIGFGAYDIAIAGGVEHMGRHPMGEGVDPNPRIIADKLVDPTALVMGQTAENVHDRYPEITKQRTDAYAARSQERYADAVKAGKIGPELVPVATRHAELGWGLATEDEPPRPGTTVEQLAGLKTPFRPHGRVTAGNAAGLNDGATGAILAAEDVAEELGLPVGMRLVSYAFAGVEPEVMGIGPVPATEKLLARTGLSISDIGLFEINEAFAVQVLAFLDHFGIAEDDPRVNQWGGAIACGHPLASSGVRLMTQLSRQFAERPDVRYGLTTMCIGIGMGGTVIWENPAWEGNK
>CP015163.1|AXB43499.1|3006819_3009072_+|chitinase
MRHTPRRLLSALLSFLLAITVSAALGRPAAAASPLTAAFTLTGTTGEYQVTNTGSTAVSGWTITFRLPAGVTATSGQHGTVTQHGTEVTLAPAHYINTLQPGKSTYPYSPTFQLSAAATPTACRIANANCDGSPDTPPSAPSNVQATVKTTKSVTLTWTASAPGSLPVAGYDVFNGNTKATTVTSPTATITGLTPNTGYSFTVVAKDTAGLASPASAPLAVRTNNPADDTLAPSAPGNLHTTGTDAGSVSLAWTASTDNTGVAAYDVYRGTALAATVTTTSAKISGLTPSTSYSFSVRARDGYDNTSAPSNTVTAKTGDIVGGYAKIGYFVQWGIYGRQFFVRNLDTNGAAAKLTHLNYAFGNIDPVNLTCLQGVTKGTTPNPQDPNQGDGAGDAEADYSRPMSAAQSVDGVADTGWEKLRGNYNQLKKLKAKHPHLKVLISLGGWTYSKYFSDVAATDAARKKFVASCLDIYLKGNLPVYNGAGGPGTAAGIFDGIDLDWEWPGAEGHPGNHVSPADKVNNTLLINEFRRQMDELGAQHGKRYQLTAFTPADPAKIEAGWELGPVANSLDIFNVQGYDFHGAGSDNSWEPNRTGHQGNLYTDPDDPYNFHFSVENAIKPYLDAGVNPRKLTVGLAFYGRGWQGVTDGGKAGEWQAANGAAPGQFAEEAGTRGYSNLVASVPNCIVHHDEAAVATSCFTGNGGQWWTFDDAWSIGKKTAWIKEKGLLGAMIWEMSGDTGVLMSATHNGLR
>CP015163.1|AXB48475.1|3006004_3006685_-|TetR-family-transcriptional-regulator
MRNTGRVGRPRANGVAASRHDAREAVLDAAAELFTTAGYTATTTRAIAELAGLRQASLYYHFPAKEDLLAALLAETVDPSLAVARELLGELAPAEVRLWALSYSDIRLLGTARHNLGVLCLLPEVKALNLTGFRAARAELKDCYRALIAEAGAEPASLDICTSLAFGLVESVASARRDNPRLDVEAHARHGADAVLRLAGLPGASGSVRAAGLALLEAAALECSRV
>CP015163.1|AXB43498.1|3005066_3006008_+|transposase
MARCVVDDQWPLRRAAERFQVSVSTARRWAGRYRAEGEAGMIDRSSRPHSSPRRTPTRTERRIIKVRVLRRWGPARIAFFLRLVPSTVHRVLARFGLARLAHLDRATGRPIRRYERATPGELVHVDIKKLGNIPHGGGHRVLGRAHSRRNARATTTERRNNRAPIGYSYLHNALDDHSRLVYSEILPDERKDTAVAFWLRAQTFFAAHGITVERVLTDNGSCYTSRAWRDTLATAGISHKRTRPYRPQANGKVERFNRTLLDEWAYARPYQSEQARRDAFPGWLHTYNHHRGHTALGGHPPASRVPNLPGQYT
>CP015163.1|AXB43497.1|3003647_3004904_+|3'-5'-exonuclease
MDTADQDGATPGSPDSPAPIPLREPAEGTPGVIADPEALAHACARIAEGTGAIAVDTERASGYRYWPKAYLVQLRREGVGSFLVDPIPLSGQLGPLADVLNGAEWVLHAASQDLPCLAELDLRPTALFDTELAGRLAGYDRVALGTLVERLLGYQLEKGHSAADWSRRPLPVDWLNYAALDVELLIPLREKLEAELEAQGKLDWARQEFEAVRTAPPPPPRAEPWRRVSGIHKIRSPRGLAAVREFWQIRDEMARKRDRAPSRVLPDSAIVSAVLADPKTTAELQALPVFSGRVQRKFASTWLRPLQVARALPKSELPLPAQPTDGPPPPNRWADKDPDAAARLSAARAALTALAEHHRLPVENLLLPELVRRTCWRPPENRDEAGVAEVLRAGGARPWQLELTVPALVKALAATAEN
>CP015163.1|AXB43496.1|3002870_3003587_+|DNA-binding-response-regulator
MAAVGLSQAVRSTPAGALPASMVPHPREELFSVLVVDDHPLLREAIAARLAQMGAGTVHEAATVAEARARATATGPCDLAILDLGLPDGSGIELVTELRSHGWPRVVVLASSDDPYAVRSAFQAGAQAYLLKSASPVVVTDGVRRVLEGGVYADPSVAPVLATGTRVAGTDNTPRELSAREVEVLQLVADGQSNKEIGEELSLSALTVKSHLSRIGRKLGTGDRAQMVALAMRAGVIR
>CP015163.1|AXB43495.1|3001613_3002222_-|hypothetical-protein
MADVLIVVLLVLVLAALVVVGVLLARRGRSAPKAEAPRADPFGSGDVDAVRGDPRTLGPGAIAEIRGESYAVRGTLRLTEDGWSWTEHLLENAAGRRFWLSVEEDPELELVLFTALTDVTVTPGKTIELDGRTYRHQESGTATFTAEGTTGLDSGGTVHYQDYAAGDDARLSLESYGQSGKWEVSRGEVLSRYEVRIYPPAG
>CP015163.1|AXB43494.1|3001157_3001586_-|hypothetical-protein
MKYRLWFVLGGVLAVIALIIAVNLLFFGGTSVANFVDNEFDRDTSQDFDTDVRSYTSGEKPSAVSTLIVTDWKPLAQSADNSGIYLRYSSDAVVITPRGTGSTIQVMDVDRAYRRYGHTSGYWGWTSTHGGDFRGRGPGAGK
>CP015163.1|AXB48476.1|3013354_3015004_-|heme-peroxidase
MMHRHSRESYYVVGEGDLSFDAERNPVSSRPSARSELRRFRFSRLGPVGEQVDPALAQELAAAMTVEQDTSGAAPVEPVPAGFTYLGQFVDHDLTLDRTAVDFGEDVSLEDLIAGRSPALDLDALYGRGPERDRHLYTDGVHLKVGTTAAVPLDGANTNRTGFDLPRKGTGETKAEERSAVIPDARNDENLAVAQTHLAFIHFHNKVADVLAAEGVPPAQLFERARAEVVRHYQWLLRTDYLPRIADPAVVTEVFTNGRRFFEPAPDAHDAATMPIEFSVAAFRLGHSMARATYQWNRFFRAGAPAGIATMLQLFIFSGTSGTLSPTGNPADLDDPNAGTFLRLPTNWIVDWRRLHDFPGAGRPDLGVPEGEGNVARRIDTLLTNPLATLPAGTFDGRGQNLAPDDIQRNLAYRNLIRANMVKLASGQQMAAFFGVKELTGDELLSGDGQGANLAALSEEHREALVARTPLWFYILREAEVHGGKLGAVGATIVAEVFSRCMDAARYSILREPAWRPRFGTAEGRFGMADLLLFAFDGDPAKLNPLGDG
>CP015163.1|AXB43503.1|3015084_3016113_-|hypothetical-protein
MTDVPLARAHAQLLAGPRADGVAEVVRQVVALQAQDIRANRLGVRVRSAGLTASDVDTACASGAVVRTWAMRGTLHMLAAEDAAWIVGLLGPRFAAAGRGRRRQLGLDDEVAARGVAALRAVLAGKSLPRNEIVAELAAHGVVLDPKSQAPAHLLAYAAMTGVICRGADAGDEPTYALFPEWVGPFETLREDEALARLASRYLAAYAPATAEDFAAWSGLTLRQARAGFADADHSEVAVVDDFSVRLLGHFDTYLLGYRSRELAVPAEHDRRIQAGGGFIMPAVLVNGRVVGTWRQERKKGVLEVRVEPFGELPGCLRSALSAEVDDLGRFLRIPVVFHSAG
>CP015163.1|AXB48477.1|3016109_3017249_-|two-component-sensor-histidine-kinase
MIPARSLRARITLLSTALSAAVSLVLLYLAWSLVGDSVAAVPELPPGTKVRVDGVNVDSSVLTAHLREHARNKVLVVGAVAFCCVVAATAVLAWTLTSRVLRPLREMTSTARRLSVESMGERIGVRNARDELGELGATLDAMLDRLQAAFDTQRRFVANASHELRTPLSVIRTELDVTLADDQADEAELRRMAGVVRDATERAEQLVSSLLLLARTDGAGVGPTEPVDLAAVVDTAWNGVYREAERRQLRTDFQLVPSYSIGDPALLERIAGNLLENAVRHNVDGGWIEAVTQPGSRWTTLRVRSSGGLVDPATVSELFEPFRREGVARTARTGAGLGLSIVRAAVQAHGGVVSAEPVVGGGLSVTVHLPALTGTGVPT
>CP015163.1|AXB43504.1|3017263_3017935_-|DNA-binding-response-regulator
MRILVVEDEEPLAEAIARGLRREGMAVDVAFTGDEGHEKSTITRYDVVLLDRDLPGMSGDELCKEIVESGELTRVLMLTASGTVEDRVAGLSLGADDYLAKPFAFPELVARVRALGRRATPAAPPLLTAGDVRLDPAKRTVSRAGGPVELTRKEFGVLEVLLSAGGSVVSSEELLERVWDENADPFTTTVRVTVMTLRKKLGEPGIIETVVGSGYRVPGAGHG
>CP015163.1|AXB43505.1|3017987_3019484_-|PucR-family-transcriptional-regulator
MARNAETFGTPVNIPLRAVVGNSELAVEVVRETLRPGALDLPVRWAHVCELRDPSPYLLGEELLLTAGVNLPAEQAEVDRYVRGLRAAGITALGFGITPPMHEQLPEPLRRACARAGLPLLVIGVRTPFIAVNRVVAVALAEAAQREQRRITQAREALTRAAAGGLAELARGLAKHVSGWVALVGKNDVLAAEHEVPSPFPPELGELFARLRGGSGIRSATTELPDGTFVVAQPVYPQATASHLVVVGRRARFDGTDRAIVAVGAALFGLASRAGSDTAGLGAAVTALVLAEHPPAAPLAELLGEGDYRVVAGFAHGAGPGDVAAGYDWLRTRLDTPLVELKPGPRFTAVVRTPPDARAREELLAAGWLVVVSAPHPVERLPDTAAELAALEQRALVLGRPVLADGSGLAALVPPGHAADYAERTLAPLRALGDDGLLDTLRTWLAHHGGWDRTASALGVHRNSVRHRIARVERVLGVDLADPETRMELWFALRWAGS
>CP015163.1|AXB43506.1|3019586_3021041_+|sodium:solute-symporter
MVADYVVIALYIAGMLGIGWYGLRLAKTKSDYLVAGRRLGWFMYSGTMSAVVLGGASTVGGVKLGYTWGISGAWLVVSIGLGILVLHALFARRLVKLKVYTVSEMLDLRYGGKSASTISGIVMWAYTLMLTVTSTLAFATVFKVLLDIPEWTGIAIGGGIVVLYSVLGGMWSITLTDIAQFVIKTIGILLVLLPVSVGAAGGFGGMAERLDASFFDFTSIGTGSIITYVLTYGFGLLIGQDIWQRVFTARTPRVATSGGIGSGVYCLIYGLAGALIGAAAKVLYPTLASAQDAFATIVADLLPAGVRGLVLAAALSAMMSTASGALIACSTVSTTDLLGKLRGRTAPSGEEAEVSKNRVTTLVLGLVAIGIAMVVTDVVAALTIAYNILVGGLLVAIIGGLFFKRGTRQGAVASMAVGALAAIVLMIVDGMAANSPIYWGLGSSLLVYLVVSLATPPTSPAVLDRWSNRLAGRETAAAEKEFTQ
>CP015163.1|AXB43507.1|3021037_3021991_+|agmatinase
MSAQSPIGPVDSSKVPRFAGFATFARLPRADQVERADVAVVGVPFDAGVSYRPGARFGPAALREASRLLRPYHPELDVSPFAAAQVVDAGDIAINPFNIGEAIETLQHEAEALTADGTKLVTVGGDHTIALPLLRAAAKKHGPVALLHFDAHLDTWDTYFGEPYTHGTPFRRASEEGILDTSALSHVGTRGPLYGKRDLEEDRRLGFGIVTSGDVLRRGVTETVDALRQRIGDRPLYVSIDIDVLDPAHAPGTGTPEAGGMTSRELLEIVRGLRGLNLIGGDVVELAPAYDHAEITAIAASHVAYDLVSLLALGKSA
>CP015163.1|AXB43508.1|3021987_3023637_+|acetolactate-synthase
MRIGGDLVVETLRALGADTVFGLPGQHALGLFEALRRAPELRLIGARVENNLAFAADGHARARLTAQPGGPVPVTPMIVSTGPGALLTLASLQESRASSVPVLGISSQVPAAGLGGGRHGYLHELPDQAASFRDVVKSVHVVRTASQIPGALREAWESAATVPYGPVWVEIPQDVLLAPAALPPITSVTATPKPLAPLPELTAEAARLLGSARNPVILAGGGVVRSGAQAELRALAELVRAPVLSSFGGKGSIAWDHPLSGQSWLEDWHSTEFLAGADVLLVLGSGLGELTSNYHRFTPRGRMIQIEADAGKLESNHPALGIHADVRLALTALLEAAPAREADGRAEAAVAELLAKVRARIGAQSLDLEQRVLAEVRAALPEGTPSFWDMTVLGYWAWSAWNADGAPIHTAQGAGGLGYGLPGALGAAAARRGPVLAVSGDGGAMYGIAELASAAQHGLDVTWLVVDDGGYGILREYMTGAFGQAHATELARPDFVALAKAFGVPATLSTVDGLRADLAKALATPGPSVVVLPALLRMFEPTHLDHPEQ
>CP015163.1|AXB43509.1|3023645_3025040_+|gamma-aminobutyraldehyde-dehydrogenase
MNFVDGKEVPATGGRTLELTDPATGEMSGTSPLSEQSDVDAALESARRAFRAWRRSTPAQRQLALLKIADALESRAEEFADAEVRETGKIRRVVLEEEVPESVSALRFFAGAARQLDGTASAEYLPGHTSSIRREPVGVCAQIAPWNYPLMMGVWKIAPALAAGNTVVLKPAETTPGTAVLLAKVAAEFLPAGAFNVICGDRDTGRALVRHPIPELVSITGSTRAGIDVATVAAADLKRTHLELGGNAPLLVFEDVNLEETAEGIVGAAFYNAGQDCTAGSRVLVHESIHDEFTAVLTKAAAAHRPGTHFGPLNSAAQLDRVRGLIDRLPAHATVHTGGTSPAGAGFYFEPTVVSGLAQDDEIVQEEIFGPVITVQRFGNEAEAVELANGVPYGLASSVWTNDHARAVRVSGELDFGCVWINTHGPLAAEMPHGGFGHSGHGKDLSAYSFAEYTRVKHVMTRYE
>CP015163.1|AXB43510.1|3025051_3025477_-|hypothetical-protein
MTRQLVVAGPSRTVVALGVAGAGLGTGVSWLDLYLLSSARDQCVVGMSAFENSGLLVFSVQPVLWAVNFLAFTLLYAGLFPLFLDGDTAAARFAGVVACLLLTAVLVAASVWISMAVWSPEQVAPGCAGGHPPWWPSWAAL

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Crispr_ID: CP015163_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP015163_4

3732201-3732296

Orphan

Consensus_repeat	Method
GTCAGCCACGAGCCGCCTCCTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP015163_4

>merge|CP015163|4|3732201-3732296|CRISPRCasFinder
GTCAGCCACGAGCCGCCTCCTTGTCCTGCGGGGCACCCGCACCCGGTCGGCACTCGTGGTGTGCTTCGCGATTGTCAGCCACGAGCCGCCTCCATG

>CP015163|4|3|3732201-3732296|CRISPRCasFinder
GTCAGCCACGAGCCGCCTCCTTG	TCCTGCGGGGCACCCGCACCCGGTCGGCACTCGTGGTGTGCTTCGCGATT
GTCAGCCACGAGCCGCCTCCATG

Protein	Signature genes	Signature genes Name	Protein_function
CP015163.1\|AXB44049.1\|3745182_3745914_-\|methyltransferase	unknown	unknown	gnl\|CDD\|237872
CP015163.1\|AXB44043.1\|3739099_3739504_+\|deazaflavin-dependent-nitroreductase	unknown	unknown	gnl\|CDD\|211538
CP015163.1\|AXB44033.1\|3724790_3726182_-\|3-deoxy-7-phosphoheptulonate-synthase	unknown	unknown	gnl\|CDD\|366662
CP015163.1\|AXB44048.1\|3744157_3745183_-\|cysteine-synthase	unknown	unknown	gnl\|CDD\|107204
CP015163.1\|AXB44041.1\|3737174_3738203_-\|prolipoprotein-diacylglyceryl-transferase	unknown	unknown	gnl\|CDD\|237284
CP015163.1\|AXB44037.1\|3728928_3729981_+\|NAD-dependent-dehydratase	unknown	unknown	gnl\|CDD\|187652
CP015163.1\|AXB44050.1\|3745910_3747377_-\|ABC-transporter	unknown	unknown	gnl\|CDD\|224048
CP015163.1\|AXB44031.1\|3719838_3721350_+\|flotillin	unknown	unknown	gnl\|CDD\|259798
CP015163.1\|AXB44035.1\|3727342_3727879_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB44042.1\|3738221_3738986_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|367243
CP015163.1\|AXB48566.1\|3721492_3722491_+\|RNA-polymerase-subunit-sigma-70	unknown	unknown	gnl\|CDD\|236196
CP015163.1\|AXB44038.1\|3729985_3730501_-\|acetyltransferase	unknown	unknown	gnl\|CDD\|225695
CP015163.1\|AXB44034.1\|3726277_3727165_-\|peptidase	unknown	unknown	gnl\|CDD\|226119
CP015163.1\|AXB44032.1\|3722509_3723106_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274424
CP015163.1\|AXB44044.1\|3739500_3740691_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
CP015163.1\|AXB48567.1\|3723403_3724657_+\|acyltransferase	unknown	unknown	gnl\|CDD\|274360
CP015163.1\|AXB44047.1\|3743399_3744161_-\|phytanoyl-CoA-dioxygenase	unknown	unknown	gnl\|CDD\|368580
CP015163.1\|AXB44045.1\|3741305_3742529_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
CP015163.1\|AXB44046.1\|3742572_3743385_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377194
CP015163.1\|AXB44036.1\|3727979_3728858_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223656

Protein	Function_ID	Function_description	E-value
CP015163.1\|AXB44049.1\|3745182_3745914_-\|methyltransferase	gnl\|CDD\|237872	PRK14968, PRK14968, putative methyltransferase; Provisional.	4.87314e-16
CP015163.1\|AXB44043.1\|3739099_3739504_+\|deazaflavin-dependent-nitroreductase	gnl\|CDD\|211538	TIGR00026, Hypothetical_protein_Rv1261c/MT1299/Mb1292c., deazaflavin-dependent oxidoreductase, nitroreductase family. This model represents a family of proteins found in paralogous families in the genera Mycobacterium and Streptomyces. Seven members are in Mycobacterium tuberculosis. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. [Unknown function, Enzymes of unknown specificity].	7.76536e-09
CP015163.1\|AXB44033.1\|3724790_3726182_-\|3-deoxy-7-phosphoheptulonate-synthase	gnl\|CDD\|366662	pfam01474, DAHP_synth_2, Class-II DAHP synthetase family. Members of this family are aldolase enzymes that catalyze the first step of the shikimate pathway.	0
CP015163.1\|AXB44048.1\|3744157_3745183_-\|cysteine-synthase	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	1.15449e-66
CP015163.1\|AXB44041.1\|3737174_3738203_-\|prolipoprotein-diacylglyceryl-transferase	gnl\|CDD\|237284	PRK13108, PRK13108, prolipoprotein diacylglyceryl transferase; Reviewed.	7.89004e-133
CP015163.1\|AXB44037.1\|3728928_3729981_+\|NAD-dependent-dehydratase	gnl\|CDD\|187652	cd08948, 5beta-POR_like_SDR_a, progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs. 5beta-POR catalyzes the reduction of progesterone to 5beta-pregnane-3,20-dione in Digitalis plants. This subgroup of atypical-extended SDRs, shares the structure of an extended SDR, but has a different glycine-rich nucleotide binding motif (GXXGXXG) and lacks the YXXXK active site motif of classical and extended SDRs. Tyr-179 and Lys 147 are present in the active site, but not in the usual SDR configuration. Given these differences, it has been proposed that this subfamily represents a new SDR class. Other atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.69154e-139
CP015163.1\|AXB44050.1\|3745910_3747377_-\|ABC-transporter	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	1.01885e-124
CP015163.1\|AXB44031.1\|3719838_3721350_+\|flotillin	gnl\|CDD\|259798	cd03399, SPFH_flotillin, Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily. The flotillin (reggie) like proteins are lipid raft-associated. Individual proteins of this SPFH family may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. In addition, microdomains formed from flotillin proteins may be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and interact with a variety of proteins. They may play a role in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and in cancer invasion, and metastasis.	1.1471e-41
CP015163.1\|AXB44032.1\|3722509_3723106_+\|hypothetical-protein	gnl\|CDD\|274424	TIGR03086, TIGR03086, TIGR03086 family protein. This family, like pfam07398 and TIGRFAMs family TIGR030834, belongs to the larger set of probable enzymes defined in family TIGR03083. Members are found primarily in the Actinobacteria (Mycobacterium, Streptomyces, etc.). The family is uncharacterized.	6.66721e-21
CP015163.1\|AXB48566.1\|3721492_3722491_+\|RNA-polymerase-subunit-sigma-70	gnl\|CDD\|236196	PRK08241, PRK08241, RNA polymerase subunit sigma-70.	2.23306e-172
CP015163.1\|AXB44038.1\|3729985_3730501_-\|acetyltransferase	gnl\|CDD\|225695	COG3153, COG3153, Predicted acetyltransferase [General function prediction only].	1.21983e-44
CP015163.1\|AXB44034.1\|3726277_3727165_-\|peptidase	gnl\|CDD\|226119	COG3591, COG3591, V8-like Glu-specific endopeptidase [Amino acid transport and metabolism].	1.8636e-05
CP015163.1\|AXB44042.1\|3738221_3738986_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	3.64616e-10
CP015163.1\|AXB44044.1\|3739500_3740691_-\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.19678e-46
CP015163.1\|AXB48567.1\|3723403_3724657_+\|acyltransferase	gnl\|CDD\|274360	TIGR02946, Putative_diacyglycerol_O-acyltransferase_Mb3115, acyltransferase, WS/DGAT/MGAT. This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity].	7.39495e-100
CP015163.1\|AXB44047.1\|3743399_3744161_-\|phytanoyl-CoA-dioxygenase	gnl\|CDD\|368580	pfam05721, PhyH, Phytanoyl-CoA dioxygenase (PhyH). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalyzing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterized by the accumulation of phytanic acid in plasma and tissues.	2.90796e-24
CP015163.1\|AXB44045.1\|3741305_3742529_-\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	5.34948e-17
CP015163.1\|AXB44046.1\|3742572_3743385_-\|hypothetical-protein	gnl\|CDD\|377194	pfam04016, DUF364, Putative heavy-metal chelation. This domain of unknown function has a PLP-dependent transferase-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the C-terminus of proteins containing DUF4213, pfam13938. The structure of UnioProtKB:B8FUJ5, Structure 3l5o, suggests that the protein has an enolase N-terminal-like fold and this Rossmann-like C-terminal domain. Structural and bioinformatic analyses reveal partial similarities to Rossmann-like methyltransferases, with residues from the enolase-like fold combining to form a unique active site that is likely to be involved in the condensation or hydrolysis of molecules implicated in the synthesis of flavins, pterins or other siderophores. The protein may be playing a role in heavy-metal chelation.	1.06817e-09
CP015163.1\|AXB44036.1\|3727979_3728858_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.8595e-41

>CP015163.1|AXB44038.1|3729985_3730501_-|acetyltransferase
MHSPLWKTRPETPEDRAAIHAVNAAAFPTAEEADLVDALRADPEAWIDGLSMVAETADGEIVGYALLTRCQVGGEPALALAPCAVRPDHQRTGAGSAAIRAGLDAARRLGENLVVVLGHPEYYPRFGFTPASGFGVRASFEVPDEALMALSLDPARPTPAGVIRYPAAFGV
>CP015163.1|AXB44037.1|3728928_3729981_+|NAD-dependent-dehydratase
MSNKVALVVGAHGIIGSNLVAHLVGLGDWTVIGLSRRGGEPAERVRHVAVDLLDAEDCHAKLGELTDVTHIFYAAYQDRPTWAELVPPNLAMLVNVVDAIEPVAAGLRHVSLMQGYKVYGAHLGPFKTPAREDDAGHLPPEFNVDQQEFLERRQQGKSWTWSAIRPSVVGGTALGNPMNLAVSIAVYATISKELGLPLRFPGKPGAYDKLLELTDAGLLARATVWAATDERCANQAFNINNGDLFRWSELWPKIARYFGMETAPPLPMSLEVVMADKEPLWNRIVAEHNLEPTPYQRVSAWPFADFVLSWDYDMFADGTKARRFGFGEFVDTEEMMWRLFDELRKRHIIP
>CP015163.1|AXB44036.1|3727979_3728858_-|LysR-family-transcriptional-regulator
MSTLRRFEYLVAVVDEGSFTRAAERLHVTQPALSHQIRALEHDAGGALLERLPRAVRLTAMGRAMLPHARAALADAERAVCAARQAAGLEAAELRVATVYSVSLGVLPPVLREWSRRHPGVAITLFEHRHTGELREAMLAGQADLAVGPRPDGWEGPVRTLGEEDFVVVLAANDPAAQGKSVRLADLADRGWVHYAPENGLAEVLDQACAAAGFTPRAAIRAAQTAAVPLLAAAGLGPALVPSNVLPDDFAGAVRLPDPPVRRELTAYTRGTPDPVAEAFGELLAARAFQEF
>CP015163.1|AXB44035.1|3727342_3727879_-|hypothetical-protein
MRKFLVRSFVAGAIASLGVLASAGVASASADGADPVFDQPGAEVGAMVTKLTHSQATSRLRSSGITWSSSGGCSDRNRPNCTSFEQVNLATIQGAQTLKSASGCGLNVTGGTETGHASGTYSHWNGYKLDFSLSSCLTNYIKGNFSAIGGNKWKAGSGNIYYLESNHWDVTFYNCGGC
>CP015163.1|AXB44034.1|3726277_3727165_-|peptidase
MRRASILTAIGLVLGALLTAPATGQAQAATDYWTPEKMRSAVPVEKLLTAPQAGVGDVLAGLPEIIPAAFPSTGGPWEGGGDVVKTAGRVFFTMGGQNASCSGNAVTSANKSTVITAGHCVKYQGAFHTNWIFVPGYDNGNAPYGEWPATSTLTTPQWEAGEDMNYDIGAAVVDQVGGQSLTDVVGSQGIAFNQPRNQNMYTFGYPAADPYDGTTLIHCSGSTFTDFLLTRDHGMSCDMTGGSSGGPWFLQFDEQTGRGVQASVNSFGYVFLPGVMFGPYFGAEAQALYNEAQAA
>CP015163.1|AXB44033.1|3724790_3726182_-|3-deoxy-7-phosphoheptulonate-synthase
MNWTVDVPVDTLPELPPLPPELRARLDEALARPAAQQPDWPDQGLTRRVRGVLESVPPITVPAEIDRLQQRLAMVANGEAFLLQGGDCAETFESNTEPHIRANLRTLLQMAVVLTYGASLPVVKVGRIAGQYAKPRSASTDSLGLPVYRGDIVNSLVAKPELRVPDPGRMIRAYANAGAAMNLVRALTAAGMADLAQLHDWNRDFVRTSPAGERYEALASEIDRGLRFMSACGVTDTSLHTTEIFASHEALLLDYERSLLRLDNADAANPKLYNLSSHFLWIGERTRQLDGAHIAFAELLHNPIGLKIGPTTTPEQAVEYVRRLDPRNEPGRLTLIARMGNGKVREVLPAIVEKVEASGHKVIWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGFFEVHRKLGSYPGGIHIELTGEDVTECLGGAQDISDIDLAGRYETACDPRLNTQQSLELAFLVAEMLRS
>CP015163.1|AXB48567.1|3723403_3724657_+|acyltransferase
MGAVVTFDGPADTAHLGRLLAARAARIPKLRKHIRPTLLPPGGAAWAEDPGFDPADHIHVHHVSSLYEPEPLAAFASLWIAEPLDMDRPLWDLCLVTGLPDGRFAVLLKLHHALTDGAGAFSIGSGLLDELPGARTPRATAAKPVAAKPPRSPLGLLKDGFSAVVAQATEGASIASSVLRAARPYPTSPISAPNADERCLGFVRLDLADLRRVRKAHGGTTNDVVLAIVAGALRSWLVNRGQRADDRTLRALIPVSVRARQQGSTDGNQLSGYLCDLPVGLDDPVARLHAVRRSMDHAKAKGTATGPGAFPILANRLPAPVHRLATRAAGRAAPLLFDTVVTNVPMPGRPLTLDGARLREIYPLVPLPPHQALGIAVSIYRESVHIGLQANGEAVADLGSLRDAFDKSTAKLVATCM
>CP015163.1|AXB44032.1|3722509_3723106_+|hypothetical-protein
MPPALAGGVALLERAVGYTLGCLRLVTDESMGNATPCRDWDLRALLAHLDDALIALAEAANLGRVGLDPVAPVPGDPAAAVRARAGELLGAWMGEPAAGPVSVAGAPMTAVVVAGAGALEIAVHGWDVARACGHDRPLPPALAAEMLELSALFVTAADRPERFAAPIAVPAGASAGDRLLAFLGRRACSHSPGLVSRD
>CP015163.1|AXB48566.1|3721492_3722491_+|RNA-polymerase-subunit-sigma-70
MSPGVDGDFLSQADPYRRELMAHCYRMLGSVHDAEDLVQETYLRAWRAYDRFEGRSSLRTWLYRIATSACLTALESRGRRPMPTGLGAPGCEPEDDLQERHEVPWLEPVPDALTGADGADPAAIVTSRESIRLALVAALQHLPPRQRAVLILRDVLKWRAAEVAELMDISTPAVNSILQRARAQLEKIAPTENEVTEPSAADQRELLDKFVTAFEAKDIPAIISLFTEDAVWEMPPFAGWYLGAERIARHLSSRCPCRPGHTRLLPTWANGQPAFGTYLRERDGERFRAFNLQVLTVGPAGISHVANFVDADLFAVFDLPESLPADYPAATA
>CP015163.1|AXB44031.1|3719838_3721350_+|flotillin
MGETDVDPLILAGVVVGAIIVLFVLLRMLYKVAEPNEALIISGWGVRVQRSETADSLGFKIITGKGVLVIPGFQTARRLSLDTRGANLQVSCVTKQGLPVTVRAVVIYKVGDDFASIANAARRFLDQQDGMNNTIHELFAGHLRSIVGGLTIEEMIHNRDALTGEIRSSSANEMIKLGLVVDSLQIQEIDDESGYILNLGKPHAAAVAASARIAEAQRDQEATEAEQVAAAQKAGAIRESEIKQAGFQAEVDQARAKAGQSGPLAEATARQEVVVQETRAAELEAALAEQRLQSEVRKPADARAYDTRTSADAERDAAIAKAQAEAKETELRAAADATKVKTAAEAEAQATKARGEASAAATRATGDAQAHAAKAQGLAEAEAARAKGLADAEAAKAKGLAEADAIKARAAALAENQEAVVAQQLAERWPEIVEAGAKAFGSVDHMVVLNGADGVSDMFSKALSLGGTGLGLARQLMEAMGQTSKPVEPEANGSVVPTTTDLR
>CP015163.1|AXB44041.1|3737174_3738203_-|prolipoprotein-diacylglyceryl-transferase
MNTAAASFLASIPSPDRGVWHIGPIPIRAYALCIIAGIVVAIWLGERRWVARGGTKGTILDIAVYAVPFGLVGGRLYHVITDWHRYFGEGKDPIQALNIVNGGLGIWGAIALGGVGAWIGARRKGIPLPAIADAIAPGIVIAQGVGRLGNYFNQELYGGHTDLPWALEIYARVSPDDPRIEDTLNGVALNNIPIDTVHPTFLYELLWNLGVALLVIWADRKLRLGHGRAFALYVAGYTLGRTWIELMRTDAATLVFGVRVNVWVSILVFAGAVVYFVAAKSRGEREAPALLKGKDGDLPDEELDDVTDVKNTDADETAVVSNGNGGESRADEPAEKPDGKDK
>CP015163.1|AXB44042.1|3738221_3738986_-|TetR-family-transcriptional-regulator
MATDNGSDPARSLAILWRTREVSSRKGKPELSVDRIARVAIELADVDGLDALSMRKVAEKLGVGTMSLYTYVPGKAELVDVMVDLVQAETARPQEGGDDWRAKLELIARENLALYQRHPWLLQASHRTVLGPNVIEKYEYELRALEGIGLTEIEMDSVLTLLIGQAQVSARGRAEMSRVERNSGLTEEQWWTQHAPLLDQVIDYSRFPVASRVGAAAGEAHHAAYSPEHAFEFGLARLLDGIEVLIGGRADAGS
>CP015163.1|AXB44043.1|3739099_3739504_+|deazaflavin-dependent-nitroreductase
MNRVFIGLQRTGLKLGGMYLLTVPGRKSGKPRTTPISLMELDGARYVVGGFPGADWVRNASAAGAGTLSCGRRHESVRLVELPVEEARPVLRAFPAKVPSGVSMMTSAGIVESDSPDEFEALAGRCAVFRIEKI
>CP015163.1|AXB44044.1|3739500_3740691_-|MFS-transporter
MNRARAALLVALAIDNFGTGLFLPLTLVYLSRVVGLPLAIAGTVVPLGTVAGLLVPPLAGRLTDRVGARLVVITAQLVQAAGVLAYLLAGSVVTVAVAAVLVAAGQQLFYCALYALVADVAGDVPKDRPFAVVGMVRAASFGAGGLVAAVLLTGFGTTGFRVALAANAVTYLLAALVLLLGLRTRTTRFLPPPRCLAAGPLRDRPYLKLILISGLFGLSLDVFLIGVPVFVLEQLHGPSWLPGAIIALLTLCTSVGGTLALRLTHRLSRIDAMRFGSMLYALWWLGCLGALLVPRAAQPGYLLAVTLIIATANLVFGPRANALAEAAAPRAARGRYLAAFQYAFTTAQVVAPAVVALFSVAVWLPWVVVAVCAVLAVFGLSGLSARLPAHAVRPPP
>CP015163.1|AXB44045.1|3741305_3742529_-|MFS-transporter
MSAETVKPVGELPVPSDLRMARLLGPVLLASAVSLLPFTVFSTFLVPISADAGTSVAAMGGLRGLGGLAALGVGAAVAPLLDRVPKQYTAGGGLVLLGLSAVLGAAGQFLALAAFCLLVGAATSVLNPALAADAADRFGSGAAAGRAATLVTATQSLTAMLAAPLVALPALLWGWRGNLLAVAVISVALSVVFFRRRPAPVAASDDGPRLGYLASFRALAGVPGAVPLLVVALLRTAAFMGYLSYLAAFYDSRFELDPELFALVWTLSGAAFFVGNLLAGRYTSAERPWIRPEHMLTASLLVALGAVAGFYFATNLVLALVLTAVLGASHATVAACVVTLLVRRCGPLRGSALGVNAAGMSLGTFAGAAIGGVGLGLAGYPGTAIAFGGITLLALAASLFVRPGAEA
>CP015163.1|AXB44046.1|3742572_3743385_-|hypothetical-protein
MESVPALTEAVLAGELGPPPGERTVTSAFWLHHTTRLAGGGVTYRNHYLLLRVGSAFGACSFEEGELDADFCATASGEPLDALIRHDRLPVRIAALDAYLADTRPHREAGAEPVVLPVGTPEVRARARDEAIAGLLDIRPGARVALIGVVNPLVAAITERGGACLPCDLNLRTTQWGQPVSREMDEVLDAADAVVATGMTLGNGSFDRLLARSRDRGLPLVIYAQTGSAVARAFLGHGVTAVSAEPFPFSQFSAEPSTVYRYRAPVGRAG
>CP015163.1|AXB44047.1|3743399_3744161_-|phytanoyl-CoA-dioxygenase
MNEPGYRILHGLFGGAELARLAEAAESVQRDVLAKAASGRTSVEVWPDGHRLESVDGTKLHWEPEATGTIRSLAPVSHLHPAFDALWTDPRLTGPMADLLGVAEPGPFVSKLNFKRAGVGSEFAWHQDFPFWYCCAGPAAADIATAMIYLDDAGAGNGALSVIPGSHRDGPAPRDRAEPTGLLVDASKVDASRERVLELPAGSVLMFPGTLVHRSAPNRSDRDRRTLLFCFQPAGRPQLAELRYRRELLADLP
>CP015163.1|AXB44048.1|3744157_3745183_-|cysteine-synthase
MHDHFAEAVKEPDLIRVRDDLLCVRFETMKIYSALGAVRRLLDTGVVRPGDTLIDSSSGIYAHALALACNRYGLHCHIVGSTTIDATLKVQLEILGATLEQVQPSRSLKLDQSLRVRRITEILRENPSYHWMRQYHDEIHYLGYREVAEQIDRAVPSGPLGLSGGVGTGASTGAIASYLGELGRDVTLIGVQPFGSVTFGAEHVADPEMIIAGIGSSIEFENVRHELYDRIHWICFEYAMSAAVDLLRSSGIFAGLSAGAAYLAAHWEHEREPGRRHVFLAADTGHRYAESAYSRHREAHDLDRMRPREVGVLSELACPWSAMDWARRPACARGHDVLGVA
>CP015163.1|AXB44049.1|3745182_3745914_-|methyltransferase
MSEESWALHASLPPTLSTAEILEVNPPRNDLHTVRSHTYRDWEFELPPGVFRPGETSKMIHDRLLDGRIPVAGRTYVAMGSGLGVEAVAAGTAGAAEIYALDVHPASVAATEQHYRRFVGDTPPLHAIVSDLFTAFPDKAQADVITFNPPAVALKTSEDPDVVRNVCVGAGITARFFDQVLARGLLAPGGEIHLIVSNTADLRGIIAHAIESGFVPEVRERRTWPDDDVQTYLFRLRAKGDAA
>CP015163.1|AXB44050.1|3745910_3747377_-|ABC-transporter
MSALVEVDGLTARAGDEFLVRDIGFRLWPGKVAALVGPSGSGKTTAALALLGESAPGVRLTGSVTVAGSAVLAGEPPPGLRGGVVSYLPQHPGSALNPARRIGTTLRELAKLHRPNESTEDVVAEALRAAQLPGDVRRRFPHQFSGGQRQRVALAQALVCGPRVLVLDEPSTGLDTVTRLRLAGELAELAATGLAILLLSHQHDLVRALADHVVLLDHGRVVATGTPDEVLGEVVPPAHDWAAPGPADALLELRGLSASVRPRGRQPILHDIDLALPPGGRIGVVGPSGSGKTTLARCIAGLHERYTGELRLDGRPLPVLRKRGRELRRRVQYVWQEVRGSFDDRRPVLDQVARTAVRLRGLDATAARGEAVELLAELGVSAEIAARHPGELSGGELQRAALVRALLAEPDVLVCDEITTALDPGTARRVTTLLARLNEQRATALLWISHDLGLIAAVTSEVLVLDDGMATGLGQPRSAPVLDRKESV

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Crispr_ID: CP015163_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP015163_5

3778449-3778582

Orphan

Consensus_repeat	Method
CAGCCACACAACACCCGCAGCGGCTCGCGCTGGCCCA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP015163_5

>merge|CP015163|5|3778449-3778582|CRISPRCasFinder
CAGCCACACAACACCCGCAGCGGCTCGCGCTGGCCCAACTTCCGCAAGACCCATACGTCGCCGGTCTGGCCCCCAGCCGCCAGGCCACCAGCGCGGGCAGCCACACAACACCCGCAGCGGCTCACGCTGGCCCA

>CP015163|5|4|3778449-3778582|CRISPRCasFinder
CAGCCACACAACACCCGCAGCGGCTCGCGCTGGCCCA	ACTTCCGCAAGACCCATACGTCGCCGGTCTGGCCCCCAGCCGCCAGGCCACCAGCGCGGG
CAGCCACACAACACCCGCAGCGGCTCACGCTGGCCCA

Protein	Signature genes	Signature genes Name	Protein_function
CP015163.1\|AXB44074.1\|3779041_3779671_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378924
CP015163.1\|AXB44073.1\|3777175_3778276_+\|Zn-dependent-hydrolase	unknown	unknown	gnl\|CDD\|293841
CP015163.1\|AXB44075.1\|3779639_3780434_-\|GlcNAc-PI-de-N-acetylase	unknown	unknown	gnl\|CDD\|274584
CP015163.1\|AXB44076.1\|3780477_3781401_-\|acyl-ACP-desaturase	unknown	unknown	gnl\|CDD\|153109
CP015163.1\|AXB44078.1\|3783240_3783717_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377120
CP015163.1\|AXB44069.1\|3771719_3774839_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377989
CP015163.1\|AXB44080.1\|3785552_3786653_-\|poly-gamma-glutamate-biosynthesis-protein	unknown	unknown	gnl\|CDD\|378215
CP015163.1\|AXB44066.1\|3766427_3767567_-\|arabinose-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|341042
CP015163.1\|AXB48573.1\|3768432_3769254_-\|nitrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
CP015163.1\|AXB48574.1\|3770043_3770994_-\|sulfonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223787
CP015163.1\|AXB44077.1\|3781551_3783201_+\|RNA-helicase	unknown	unknown	gnl\|CDD\|223587
CP015163.1\|AXB44079.1\|3783949_3784900_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|181818
CP015163.1\|AXB44067.1\|3767563_3768427_-\|ABC-transporter	unknown	unknown	gnl\|CDD\|224041
CP015163.1\|AXB44072.1\|3775933_3777106_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173840
CP015163.1\|AXB44083.1\|3789215_3789914_+\|protein-phosphatase	unknown	unknown	gnl\|CDD\|223704
CP015163.1\|AXB44071.1\|3775327_3775912_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|225138
CP015163.1\|AXB44070.1\|3774835_3775303_+\|dynein-regulation-protein-LC7	unknown	unknown	gnl\|CDD\|214939
CP015163.1\|AXB44081.1\|3786691_3787579_-\|protein-kinase	unknown	unknown	gnl\|CDD\|270916
CP015163.1\|AXB44068.1\|3769262_3770033_-\|nitrate-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223673
CP015163.1\|AXB44082.1\|3787589_3789149_-\|SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|280533

Protein	Function_ID	Function_description	E-value
CP015163.1\|AXB44074.1\|3779041_3779671_+\|hypothetical-protein	gnl\|CDD\|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	1.08288e-09
CP015163.1\|AXB44073.1\|3777175_3778276_+\|Zn-dependent-hydrolase	gnl\|CDD\|293841	cd16283, RomA-like_MBL-fold, Enterobacter cloacae RomA and related proteins; MBL-fold metallo hydrolase domain. Derepression of the romA-ramA locus results in a multidrug-resistance phenotype. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	3.10815e-72
CP015163.1\|AXB44075.1\|3779639_3780434_-\|GlcNAc-PI-de-N-acetylase	gnl\|CDD\|274584	TIGR03445, mycothiol_MshB, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase. Members of this protein family are N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase, also called 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, the MshB protein of mycothiol biosynthesis in Mycobacterium tuberculosis and related species. [Cellular processes, Detoxification].	8.31314e-52
CP015163.1\|AXB44076.1\|3780477_3781401_-\|acyl-ACP-desaturase	gnl\|CDD\|153109	cd01050, Acyl_ACP_Desat, Acyl ACP desaturase, ferritin-like diiron-binding domain. Acyl-Acyl Carrier Protein Desaturase (Acyl_ACP_Desat) is a mu-oxo-bridged diiron-carboxylate enzyme, which belongs to a broad superfamily of ferritin-like proteins and catalyzes the NADPH and O2-dependent formation of a cis-double bond in acyl-ACPs. Acyl-ACP desaturases are found in higher plants and a few bacterial species (Mycobacterium tuberculosis, M. leprae, M. avium and Streptomyces avermitilis, S. coelicolor). In plants, Acyl-ACP desaturase is a plastid-localized, covalently ACP linked, soluble desaturase that introduces the first double bound into saturated fatty acids, resulting in the corresponding monounsaturated fatty acid. Members of this class of soluble desaturases are specific for a particular substrate chain length and introduce the double bond between specific carbon atoms. For example, delta 9 stearoyl-ACP is specific for stearic acid and introduces a double bond between carbon 9 and 10 to yield oleic acid in the ACP-bound form. The enzymatic reaction requires molecular oxygen, NAD(P)H, NAD(P)H ferredoxin oxido-reductase and ferredoxin. The enzyme is active in the homodimeric form; the monomer consists mainly of alpha-helices with the catalytic diiron center buried within a four-helix bundle. Integral membrane fatty acid desaturases that introduce double bonds into fatty acid chains, acyl-CoA desaturases of animals, yeasts, and fungi, and acyl-lipid desaturases of cyanobacteria and higher plants, are distinct from soluble acyl-ACP desaturases, lack diiron centers, and are not included in this CD.	4.881e-126
CP015163.1\|AXB44078.1\|3783240_3783717_+\|hypothetical-protein	gnl\|CDD\|377120	pfam03745, DUF309, Domain of unknown function (DUF309). This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	9.00626e-19
CP015163.1\|AXB44069.1\|3771719_3774839_+\|hypothetical-protein	gnl\|CDD\|377989	pfam08376, NIT, Nitrate and nitrite sensing. The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations. The NIT domain is predicted to be all alpha-helical in structure.	6.29037e-31
CP015163.1\|AXB44080.1\|3785552_3786653_-\|poly-gamma-glutamate-biosynthesis-protein	gnl\|CDD\|378215	pfam09587, PGA_cap, Bacterial capsule synthesis protein PGA_cap. This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein.	2.40347e-88
CP015163.1\|AXB44066.1\|3766427_3767567_-\|arabinose-ABC-transporter-permease	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.59921e-36
CP015163.1\|AXB48573.1\|3768432_3769254_-\|nitrate-ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	5.9078e-61
CP015163.1\|AXB48574.1\|3770043_3770994_-\|sulfonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|223787	COG0715, TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism].	8.70961e-43
CP015163.1\|AXB44077.1\|3781551_3783201_+\|RNA-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	1.0382e-123
CP015163.1\|AXB44079.1\|3783949_3784900_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	2.54104e-128
CP015163.1\|AXB44067.1\|3767563_3768427_-\|ABC-transporter	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	4.17802e-110
CP015163.1\|AXB44072.1\|3775933_3777106_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173840	cd01151, GCD, Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.	0
CP015163.1\|AXB44083.1\|3789215_3789914_+\|protein-phosphatase	gnl\|CDD\|223704	COG0631, PTC1, Serine/threonine protein phosphatase [Signal transduction mechanisms].	6.1805e-72
CP015163.1\|AXB44071.1\|3775327_3775912_+\|ATP-binding-protein	gnl\|CDD\|225138	COG2229, COG2229, Predicted GTPase [General function prediction only].	3.51694e-43
CP015163.1\|AXB44070.1\|3774835_3775303_+\|dynein-regulation-protein-LC7	gnl\|CDD\|214939	smart00960, Robl_LC7, Roadblock/LC7 domain. This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	7.77656e-23
CP015163.1\|AXB44081.1\|3786691_3787579_-\|protein-kinase	gnl\|CDD\|270916	cd14014, STKc_PknB_like, Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	2.82533e-99
CP015163.1\|AXB44068.1\|3769262_3770033_-\|nitrate-ABC-transporter-permease	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	2.20687e-48
CP015163.1\|AXB44082.1\|3787589_3789149_-\|SAM-dependent-methyltransferase	gnl\|CDD\|280533	pfam02384, N6_Mtase, N-6 DNA Methylase. Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	6.30643e-31

>CP015163.1|AXB44073.1|3777175_3778276_+|Zn-dependent-hydrolase
MRTRNLVTAAIAAAGAAGLGLIGLAARGLPEAVGGRPDPEQLKRSPQFRDGRFRNEAPRRVVEQGTYRKVLHDLLFGNEPRHPGGPVPVVATSEPAPADGLHLTWYGHASTLVEIDGARVLLDPVWSERCSPSPLIGPKRMHAPPIALEDLPRLDAVVISHDHYDHLDLPSIRTLVEHQDAPFVVPLGVGAHLRRWRVPEERIVELDWHAEFIAGDLRLVATPAQHFSGRWLANDGTLWASWSIIGPRHRVFYTGDTGYFPGFAKIGEQYGPFDATLVQIGAYAPSWPDIHMTPEEGVATHLDVRGGLLVPVHWATFNLAMHAWTDPADRIWREAKAKDVALAVPRPGERVDVATPPPVDGWWQTL
>CP015163.1|AXB44072.1|3775933_3777106_+|acyl-CoA-dehydrogenase
MSATPDPRDFLDLDAELTGEERDIRDAVREYAAEQLAPNVAGWYETGALPAAELAKGFGQLGLLGMHLEGYGCAGTSAMAYGIACRELEAVDSGLRSFVSVQGSLAMYAIHRWGSEEQKAEWLPRMATGEALGCFGLTEPDAGSDPGSMRTRAVRDGSDWVLDGTKMWITNGTVAEVAVVWAQTEDGIRGFVVPTSTPGFTANEVKHKLSLRASLTAELVLEGVRLPASAAFPEVRGLRGPLSCLNEARYGILFGVVGAARACYESALDYTLSRTQFGKPLAGFQLTQRKLADLLVEVNRAGLIAMRIGRLKDAGSLHHHHVSFGKLSNVRSALEVARTARSMLGANGISLEYPVMRHMANLETVLTYEGTEEMHALTLGQSVTKLAAFR
>CP015163.1|AXB44071.1|3775327_3775912_+|ATP-binding-protein
MNAPRPSSGPTSSAKIVVAGGFGSGKTTLVGAISEIDPLTTEASMTEAGAGVDDISATPNKTTTTVAMDFGRITLDSDIVLYVFGTPGQHRFWFMWDDLALGAIGAVVLIDTRRLADAFPSIDFFENRKLPYVVAINCFDRLLHHQIEDVRHALTISPSVPIMACDARDRESAKQVLISVVQHAIQHDSARRAG
>CP015163.1|AXB44070.1|3774835_3775303_+|dynein-regulation-protein-LC7
MTGAQPEGTSQPSTLANGGFAWLITDFVRRVPGAAHAVVVSADGLMLAHSRGLPKDKADQLAAVASGLTSLARGASKIFEGGTVAQTVVEMANGFMFLMSVSDGSCLAVLGAPDSDIGLVVYEMTLLVDRVGKQLTPAQRAQLRGASGPRPVASL
>CP015163.1|AXB44069.1|3771719_3774839_+|hypothetical-protein
MEPTTADALDTTPVERGKVSRWSLRNWRLRSKLAAVMIVPTVTALALGGLLAAQELERANEFQQTVDQLDLAAKSATVLHEVQNERTLAVAKIASDRAPDEGALDAQIIKTDRAIADMKSFAGSLGTDVVPEGSQMARTLDRIDALGPLRIAVRNTSYADLSALSAYTSLLDQLVQAGREVNTGITDRDLLRRGTTAQALSEAKEYVSRENAALQIAGRRDGFPAELLSQTRAYQASARAALDTFRSTADPEQVQLYNDNVSGAEVDDRERIKASAFVFADARSRPAIDVNALTNDGNFVVDRMNKVEGQLLADLRAAADGLASDALVAFWQFAAIVLVALLFAIALMLIIARSLLHPLRTLRTNALDVAYAKLPTTVQGILDNPNPLEAAKRAVEPVPVLTREEIGEVARSFDAVHAQAVKLAAEQALLRENVNGMFVNLSRRSQRLVERQLGVIDRLEADEQDPDHLASLFELDHLATRLRRNGESLLVLSGAGLTKSVSRPVPAVEVIGAAVSEIEQYARVEVGQVPEVSVQGRAIQDLVHLLAELLDNATYFSEPETKVTMRAAVTRKRSLAIQITDKGVGMSEEDIEEANKRLADPPAFDVSVTRRMGLYVVARLAKRHGIEVRLRDNEEIDNGIIARIVVPAELLVATPAPQSLGGPPSQPRLPAQPSTPPTQSSLPPITPVYQQQKPERPAETWSPSPPPPTPAETSATSNGLTPLAQPISLDDLVAGSSNAAFTSKPTDAPLTSSFPVPQQLPVRQPAAAPEPEPEPQPAAQEDFGFPTEEPDQPATDYSDYQALANQPADDDPDAPTRRLPIYQSVMSRWFSEVEDELDEQQSQAPASSELAGPAADRDRTREAERQAQPEPASQAAPEPEPEQPATQAAQAAQSSPAVPEQATSTPEPEFTEGPPPKPRPVVASTWQSASDQGWQAAQALLETRSEEITEAGLPKRVPNAYLVPGSVGAPEQDAFRDTSVGQPSPSAISRSAAAARSRMASFQRGFTTGRHALAENAGEPGSYPGASSSRTEQGTREWQ
>CP015163.1|AXB48574.1|3770043_3770994_-|sulfonate-ABC-transporter-substrate-binding-protein
MLASTSGCGLLGGDEGDSAAQGNGQVEKAKIKVSVMPLIDVAPFHLANKKGYFKEEGLEVETVNSPSGQAGLTKLIAGDVDISYGGDIPFVMANATGSADIKFVAESSSGKPNTMMILTVPTSPVKNVQDLAGKKIAINGEKGVSDTLTKSVMKANNVDFSKVTWVTLPFPEIAGAISRGDVDAGFLVEPFITQASKSVGTVPVVDASSGPTQDFPISAYGATAKFVNENPKTVEAFQRAMARATKEAEADRKVVEPLLVEFAKIDADTAALASLTKFESKLDPARLQRVPDLMLEFGIITQKVDAAAMIAKQPQD
>CP015163.1|AXB44068.1|3769262_3770033_-|nitrate-ABC-transporter-permease
MPRLLRNLIGLAGFFLLWEGAVQTGLVRREFIPPPSVVLSSLAELLGDVSFLRDVIATMLAWLIALGIAVVVAIPAGLLLGSIPPLQVATRAIVEFLRPIPPVALIPLVILIVGGGPEAKITLAVYASVWPILFNTVYAMAEIDPVLTETAKSFGTSKSRMLTSVALPHAAPFVFTGIRMSAAIALIVIVSTEFVAGASRGIGNFVLEASEGGGRRDLVLAGTVVAGIIGYLINEGLERTGRRLFAWSEVRTEVVK
>CP015163.1|AXB48573.1|3768432_3769254_-|nitrate-ABC-transporter-permease
MPERKAGAGLRGRTKAGVSGFLRNWLLFIGLVVLWELATRVAQDPFFPPPSEILSAAGRLWFSENLTEHILPSIGRMLGGWLIAVVLGVGIGVALGRTRTGMDYAGPLFSFGRSIPPPTLAPVFLVLFGIGPGMQLATIIFGALFPILLNTVDGVRSVDAVKVDTARSFRSPRRYWLLLVVLPAASPKIFAGLRLSLSISMILMVVSELIGAFDGIGYALNSSRQIFDFPGMWAWIVLLGILGYGFNTALLAVERRVLRWQPSRAQQDANLGG
>CP015163.1|AXB44067.1|3767563_3768427_-|ABC-transporter
MPTMLDVAGLSHRYGGGDQTHTVVDDLAFTVEAGELACIVGPSGCGKSTLLRCVAGLIKPSAGEVRLHGDLIDGVPDDLAVVFQDYSRSLFPWLSVRANVEFPLRWRGLSKAERHRRADEALASVNLPDIGGKYPSQLSGGMQQRVSIARALASEPALLLMDEPFASVDAQTRFELEDLLRRVQRERGSTVLLVTHDIDESVYLSDRVLVLSKSPAKIVADLRVGLPAERDQITTRESAEFVSLRGEVARLLHGGQPATDAEKLAAADLAEADAAEQLADTRSKETL
>CP015163.1|AXB44066.1|3766427_3767567_-|arabinose-ABC-transporter-permease
MSPLRHRDFRLVLLSTALLFSGYALLLSVVPLWVVHRGSGEFAAGAATGVFMGATVAAQCVVPALAARFGYRLVTAAGGLLLGVPAPLLVLTTDWPGILGVSLVRGLGFGLVSVCGSALIGELLPASSAARGSGWYGLATGLPQLLGLAAGTWAAGTWGFTEVFLVATALPLAGVLPLLLLPKLLPGDSGPVVRWTEVGTRTWRPGLVLFSGAVGLGAMATFVPLVLNGPAAAVSAMLFVVTGAALLGRWSAGLFAHRISGSGGMLGVATVVLGLGMAVFAVTGPIGGAWALAAAIAGGAVFGAGFGVVQNDALVVMFARVPPGAAGVVWNLAFDAGQGAGAVLVGALLAGIGPVGGFGVLAGFALVLLPVARRARVTG
>CP015163.1|AXB44074.1|3779041_3779671_+|hypothetical-protein
MVQPLRELGVTTEAVSLPTCRIPGATLHDNADAVREVLAATGEPTILSGHSYGGMVITDAATGFGSTVERLVYLAAVVPEAGRSLADMSPEPSPWLDALDDGTVAVKPGLDLRGIFLQDCPDDLAAEAATRLTPQSTAAFAQAPRGLAWQTIPSTYVVLTRDRATPPARQREWSRHAHEVVELEAGHHPFLSRPAELARLTTRRADPSR
>CP015163.1|AXB44075.1|3779639_3780434_-|GlcNAc-PI-de-N-acetylase
MATLVTFHAHPDDECITVGGVMRKAYEEGHRVVLVVATQGEHGEVEEGFLTDGETLRERRIAETHAAAGILGAQRVEFLGYTDSGMMGEPENDAEGSFWTAPVEEAAEKLAAILREENADVLTIYDDNGGYGHPDHIQVHRVGMRAAELAGTPRVYQATQNRDEIRRGVEAAKAEGADMSDFGEDLDFLSTIGKPEAELTAKVDVTAYLEHKRQAMRAHASQIAEDSWFLAQSEEAFRFQFGTEWFIREGQGPGITEKDLLAGL
>CP015163.1|AXB44076.1|3780477_3781401_-|acyl-ACP-desaturase
MPISETTRLLLELEPVAEANLNRHLEVAKEWMPHEYVPWSLGRNFADLGGEPWEPGQSEVPAIARTALEVNLLTEDNLPSYHREIERAFGRDGAWGTWVHRWTAEEGRHGICLRDYLLVTRAVDPVELERARMATMQAGYDSEDKPLLRVFAYVSFQELATRLSHRNTGRYTQDPIADKLLARVSMDENLHMIFYRNLVTAALEVTPDAMVRAITDEVVGFQMPGSIIPGFVRKAAQIAKAGIYDLRIHHDEVIWPLLRHWRVFELEGLGEEGERARDELHEFLTGLEKQATRFVERRAQALARQPG
>CP015163.1|AXB44077.1|3781551_3783201_+|RNA-helicase
MSGRQQEFADLGLPAPLIAALAEQGVLTPFPIQAATLPHSLSGRDVLGRGRTGSGKTYAFALPVLARLAAKPVKRRPGRPRALILAPTRELVTQIEASMAPLAKALSLRTMTVFGGVGANPQIAALKAGVDIVIACPGRLNDHVASGHAHLDAIETTVLDEADHMADLGFLPAVRRILDATPRDGQRLLFSATLDAGVDVIVRRYLTDPVTHSVDSAQSPVATMTHHVLHVHEDDRLPVLVDLTSAPGRTLVFTRTKYRAKALTRKLVAAGVPAVELHGNLGQNARTRNLAAFSDGTAKALVATDIAARGIHVDDVTLVIHADPPVEHKAYLHRSGRTARAGASGTVVTLMTDEQVPDVRDLTRKAGIKPKTTRLDAGHPLLAELAPGERSVVKPAAKAPKAPPKAAAKTRPTARTGGQARSGARSGGQAHSGAQARSGGQSRSGAAARSGGQSRSGAQASSGGQARSNGQSRSGAQARSGGQSRSGAPAQQGRAQAPGRSQPKGQRDQQPPAKAQPKTGNQRPQRSGAPGASGAAKFSAGSRAGRRVR
>CP015163.1|AXB44078.1|3783240_3783717_+|hypothetical-protein
MRDRDPEGRARNARPRDGLGRPLPYGSPGVERQPEGVERTPAETLAEAQRLLDAGMPFHAHEVFEDAWKTGPEAEEGLWRGMAQLAVGLTHAARGNAVGGASLLRRGAANIEPYRADEPYGIDIAGLVQWAAKLAAELETQPAVVEPERAAPRLARTA
>CP015163.1|AXB44079.1|3783949_3784900_+|AraC-family-transcriptional-regulator
MLKTVAALVIDGVAPFELGVLCEVFGVDRTDGGVPPIEFRVCGERAGQPVRTSMGMSLTPDHGLGGLEGADLVALPAYDIRDAYPEAPLQAVCAASARGATVLTVCSGAFFLGATGLLDGRRCTTHWRHAKAFAERFPKTSLDPDVLFVDDGDLITSAGTASGIDACLHLVRRELGSEVATLIARRMVVAPQREGGQRQFVETPIPECTGDSLQPLLAWLLENLTVEHTVASLARRAKMSERTFARRFAAETGTTPNRWLSTQRVLHARRLLEETTLNVDEIAAETGFGTAALLRHHFHRVVGVSPKDYRRSFAPG
>CP015163.1|AXB44080.1|3785552_3786653_-|poly-gamma-glutamate-biosynthesis-protein
MERRFVSAALLGALLVTGCSSPPESPPTVEPPAVAPPPGFSVVATGDVLVHPALTDQAEADGGGKLDFRPQFDGVRPVVSGADLGLCHLEVPLADPGGPYSGYPSFNAPPEIAGALKETGYDACSTASNHTLDQGEDGVKRTLDGLDAAGLKHTGSARTSKEAGTPLVLDAAGTKVGHVSFTFGFNGIELPDGKPWMSNQLDAADVLAAARKTREAGAEVVIASLHWGTEYRAEPTKEQTALAEKLLKDESIDLIIGHHAHVVQPIEKIGSKWVAYGLGNHIAKHSEPRGTTEEGVAARFHFTKKDGAWAVDRAEYVPTLVELGPPIRLVDATVAETPRQREALARTDEVVLSRNAAADGLTRPGK
>CP015163.1|AXB44081.1|3786691_3787579_-|protein-kinase
MLIADRYELDDLPLGQGGMGAVHAGHDKHLGRRVAVKFLRLPGGPDDELERRFVREARILARLEHAGVPVLYDFGMFEQRLFQVMQFIDGVTVADLVGEHGPLPVPWAAAIAAQASAVLAAAHQLSICHRDLKPTNLMLCPDGSVKVLDFGLAMLREADVAQFTRAGQILGTPAYMAPEQIQRGVAEPRSDLYALGCVLHEMLTGNQLFTGPTAFAVFEKQVREQPPRLPGELGALLGQVLAKAPEDRPSTAAELFERLRPFTADPPMLPGYLTPSVSPARMYASMVGQLHGMGG
>CP015163.1|AXB44082.1|3787589_3789149_-|SAM-dependent-methyltransferase
MNQEATVTAGDIARLVDVGRAAVSNWRRRYDDFPRPVGGTASSPLFSLAEVEDWLRRNGKRFEVSRAERVWQRLRAAADDLGLGELVADTGAALENGGFRADEQLTGAVAELGGREVFEFLYERYQEVHARRLPVTPGPIAELMARLAGRVDTVFDPACGTGALLLAAAAPHAFGQDLDETAAAMAGTRLRLAGIDARVVAGDSLRHDAFDAELADAVLCDPPLNERAWGHEELAGDARWEYGVPPRGEPELAWVQHCLAHVRPGGTVAILLPPAVAGRRSGRRIRGNLLRAGALRAVVTMPDGTRDLWLLRRPEPGSGADRVLLMESTEDFSAVEKAWGEPESWPTRVIDLLDDDVDLSPARHRGSEGGESFVAALAGFRALGLEPPDLGVFEQDRSWPLTTIGELIKAGLVRKSGAGVPVKSPAGTEYRVDPERIDPDFLAGLLRSAMHRMTSNSTRLDLRRVRVPRLPLAEQRAYGLAFRRLAEFEAALAEAAGLGERLVRLGFDGLADGHLQPGS
>CP015163.1|AXB44083.1|3789215_3789914_+|protein-phosphatase
MTHELRAVVGTDPGLNRKGNEDAAYAGSRVLVLADGMGGHTSGEVASALAVDALRELDKEPHEDLTGALAAAVAEAGRRLNEHAPAGAGTTVTAMLWDGPRFGLAHIGDSRGYLLRDSILYQMTRDHTLVQTLVDEGRITPEEAEVHPRRSMLVRALQSGTTHEPDLSEHEAVPGDRYLLCSDGLTDVVRDEAIREVLDAVADPEAAVHQLIELANAGGGPDNITCVLADYR

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Crispr_ID: CP015163_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP015163_6

4307601-4307810

Orphan

I-E:I-C,I-E,II-B

Consensus_repeat	Method
GTCTTCCCCGCGCGAGCGGGGATGGTCC	CRISPRCasFinder
GTCTTCCCCGCGCGAGCGGGGGTGGTCCNN	CRT

3 spacers

WYL

The CRISPR arrays of CP015163_6

>merge|CP015163|6|4307601-4307810|CRISPRCasFinder,CRT
GTCTTCCCCGCACGGGCGGGGGTGGTCCGGCCGGGCTGGTGCCGCTGGAGACGCTGGAGTCGTCTTCCCCGCGCGAGCGGGGATGGTCCCGCGGCCAGCTCCCCGCGGCGTACCGGCACCATGTCTTCCCCGCGCGAGCGGGGGTGGTCCTGGGGCAGGCCAAGAGCCATCGCGACCAGATCGTCTTCCCCGCGCGAGGGGGTGGTCCCT

>CP015163|6|5|4307601-4307810|CRISPRCasFinder
GTCTTCCCCGCACGGGCGGGGGTGGTCC	GGCCGGGCTGGTGCCGCTGGAGACGCTGGAGTC
GTCTTCCCCGCGCGAGCGGGGATGGTCC	CGCGGCCAGCTCCCCGCGGCGTACCGGCACCAT
GTCTTCCCCGCGCGAGCGGGGGTGGTCC	TGGGGCAGGCCAAGAGCCATCGCGACCAGATC
GTCTTCCCCGCGCGAGGGGGTGGTCCCT

>CP015163|6|1|4307601-4307810|CRT
GTCTTCCCCGCACGGGCGGGGGTGGTCC	GGCCGGGCTGGTGCCGCTGGAGACGCTGGAGTC
GTCTTCCCCGCGCGAGCGGGGATGGTCC	CGCGGCCAGCTCCCCGCGGCGTACCGGCACCAT
GTCTTCCCCGCGCGAGCGGGGGTGGTCC	TGGGGCAGGCCAAGAGCCATCGCGACCAGATC
GTCTTCCCCGCGCGAGGGGGTGGTCCCT

Protein	Signature genes	Signature genes Name	Protein_function
CP015163.1\|AXB44494.1\|4303550_4304141_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB44495.1\|4304548_4304950_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB44502.1\|4315302_4316340_-\|3-isopropylmalate-dehydrogenase	unknown	unknown	gnl\|CDD\|179579
CP015163.1\|AXB44499.1\|4309864_4311352_-\|glutamate--tRNA-ligase	unknown	unknown	gnl\|CDD\|234953
CP015163.1\|AXB44496.1\|4305049_4306198_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378910
CP015163.1\|AXB44505.1\|4322663_4323557_+\|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|274681
CP015163.1\|AXB44489.1\|4299253_4300225_-\|DNA-binding-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
CP015163.1\|AXB44497.1\|4306816_4307485_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378511
CP015163.1\|AXB44491.1\|4300736_4301351_-\|haloacid-dehalogenase	unknown	unknown	gnl\|CDD\|319787
CP015163.1\|AXB48648.1\|4301432_4301768_+\|ArsR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|223713
CP015163.1\|AXB44501.1\|4313463_4315071_-\|citramalate-synthase	unknown	unknown	gnl\|CDD\|237068
CP015163.1\|AXB44500.1\|4311451_4312705_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|235729
CP015163.1\|AXB48650.1\|4320242_4321841_-\|phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|237436
CP015163.1\|AXB44504.1\|4322007_4322574_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
CP015163.1\|AXB44493.1\|4302465_4302996_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB44490.1\|4300314_4300716_+\|enamine-deaminase-RidA	unknown	unknown	gnl\|CDD\|100004
CP015163.1\|AXB48649.1\|4312679_4313453_-\|2-hydroxyhepta-2,4-diene-1,7-dioate-isomerase	unknown	unknown	gnl\|CDD\|223257
CP015163.1\|AXB44498.1\|4309004_4309784_-\|HAD-family-hydrolase	unknown	unknown	gnl\|CDD\|223943
CP015163.1\|AXB44503.1\|4316612_4319948_-\|peptidase-S8	unknown	unknown	gnl\|CDD\|173800
CP015163.1\|AXB44492.1\|4301751_4302357_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102

Protein	Function_ID	Function_description	E-value
CP015163.1\|AXB44505.1\|4322663_4323557_+\|LLM-class-F420-dependent-oxidoreductase	gnl\|CDD\|274681	TIGR03620, F420_MSMEG_4141, probable F420-dependent oxidoreductase, MSMEG_4141 family. Members of this protein family, related to F420-dependent oxidoreductases within the larger family of a bacterial luciferase (an FMN-dependent enzyme), occurs only within the small subset of species that synthesize F420. Most such proteins are from members of the Actinobacteria, but at least one species, Sphingomonas wittichii, belongs to the Alphaproteobacteria. [Unknown function, Enzymes of unknown specificity].	1.4848e-78
CP015163.1\|AXB44502.1\|4315302_4316340_-\|3-isopropylmalate-dehydrogenase	gnl\|CDD\|179579	PRK03437, PRK03437, 3-isopropylmalate dehydrogenase; Provisional.	0
CP015163.1\|AXB44498.1\|4309004_4309784_-\|HAD-family-hydrolase	gnl\|CDD\|223943	COG1011, COG1011, Predicted hydrolase (HAD superfamily) [General function prediction only].	1.52028e-34
CP015163.1\|AXB44489.1\|4299253_4300225_-\|DNA-binding-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	3.53023e-39
CP015163.1\|AXB44497.1\|4306816_4307485_+\|hypothetical-protein	gnl\|CDD\|378511	pfam10935, DUF2637, Protein of unknown function (DUF2637). This family of proteins has no known function.	4.65179e-06
CP015163.1\|AXB44496.1\|4305049_4306198_+\|hypothetical-protein	gnl\|CDD\|378910	pfam12671, Amidase_6, Putative amidase domain.	5.75938e-23
CP015163.1\|AXB48648.1\|4301432_4301768_+\|ArsR-family-transcriptional-regulator	gnl\|CDD\|223713	COG0640, ArsR, Predicted transcriptional regulators [Transcription].	3.13118e-07
CP015163.1\|AXB44501.1\|4313463_4315071_-\|citramalate-synthase	gnl\|CDD\|237068	PRK12344, PRK12344, putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional.	0
CP015163.1\|AXB44500.1\|4311451_4312705_+\|hypothetical-protein	gnl\|CDD\|235729	PRK06185, PRK06185, FAD-dependent oxidoreductase.	0
CP015163.1\|AXB48650.1\|4320242_4321841_-\|phosphoglycerate-dehydrogenase	gnl\|CDD\|237436	PRK13581, PRK13581, D-3-phosphoglycerate dehydrogenase; Provisional.	0
CP015163.1\|AXB44504.1\|4322007_4322574_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.40399e-08
CP015163.1\|AXB44491.1\|4300736_4301351_-\|haloacid-dehalogenase	gnl\|CDD\|319787	cd02588, HAD_L2-DEX, L-2-haloacid dehalogenase. L-2-Haloacid dehalogenase catalyzes the hydrolytic dehalogenation of L-2-haloacids to produce the corresponding D-2-hydroxyacids with an inversion of the C2-configuration. 2-haloacid dehalogenases are of interest for their potential to degrade recalcitrant halogenated environmental pollutants and their use in the synthesis of industrial chemicals. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.91039e-62
CP015163.1\|AXB44490.1\|4300314_4300716_+\|enamine-deaminase-RidA	gnl\|CDD\|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	1.47497e-22
CP015163.1\|AXB48649.1\|4312679_4313453_-\|2-hydroxyhepta-2,4-diene-1,7-dioate-isomerase	gnl\|CDD\|223257	COG0179, MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism].	1.16304e-100
CP015163.1\|AXB44499.1\|4309864_4311352_-\|glutamate--tRNA-ligase	gnl\|CDD\|234953	PRK01406, gltX, glutamyl-tRNA synthetase; Reviewed.	0
CP015163.1\|AXB44503.1\|4316612_4319948_-\|peptidase-S8	gnl\|CDD\|173800	cd07474, Peptidases_S8_subtilisin_Vpr-like, Peptidase S8 family domain in Vpr-like proteins. The maturation of the peptide antibiotic (lantibiotic) subtilin in Bacillus subtilis ATCC 6633 includes posttranslational modifications of the propeptide and proteolytic cleavage of the leader peptide. Vpr was identified as one of the proteases, along with WprA, that are capable of processing subtilin. Asp, Ser, His triadPeptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	8.61626e-46
CP015163.1\|AXB44492.1\|4301751_4302357_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	1.77101e-09

>CP015163.1|AXB44497.1|4306816_4307485_+|hypothetical-protein
MSTTIRRDLALWVQCFCTALVALDAAYASYRHGRDFALRFGSDHTTAAIWPLIVDGLLIIATVELWKGPAKQTGRWAAWLAFTLGISLSLCANIAAAPHLSVFAIAVAACPPLALLLAVELLNRALKRHRTTHNTTTESGTASTPRQEPTAPAPLSAEERMWQHYLAELEQGRTPTGAELDRVAGTHNYGRRLLRKWRATGRLPDHKQDQQTAAGTTSRQAA
>CP015163.1|AXB44496.1|4305049_4306198_+|hypothetical-protein
MAALTTLLTTAPAALAQDTSDDALLQLTARYLQDRANRVTEQAASYGALTSVEATEPFQHRLSTESAELDRLRSLWKDTASELQGAHIEIKAPQIQRSNTKAVINFVERTELHFANRTSADSPASTSYKVGHTIDFVRTSTGWELAADVLDLPQNTVDPIPYFRPVKTGDAVPSAPPAGKPVPPSLRPATPPSPGIEKPAAPPLSAAASYSRQAMADYARKWALGRNPAYESFGNDCANFVSQSLRAGGWKNVANYHNTPDAWRHLVAAAGRQLNSNTWSVSHDQLYFGWTYSGRTRNIVGEPVYLGALVYADWATAGGGVGHDGHIDHAMIVSKVTDHWDWNQIYLSYHTTDTLDISMTQLYHKGGGDAVNYYFFDLNDAA
>CP015163.1|AXB44495.1|4304548_4304950_+|hypothetical-protein
MVATRSTAQAVDGTTSYWVTALLEAGGNSYGSVLARVDDPPITSAEPTCAGWMQPCSTREVANGTAVVIDRRAQGTVLADLYRPDRTQAVHVVASDLVTSDQAKFWHGGNRYTAPLPTPEIVTEIAVQIANPQ
>CP015163.1|AXB44494.1|4303550_4304141_+|hypothetical-protein
MHEGTGETPQLPSPIDLLAAFPCPAAVADAAMACGPISSFRADGVNGNPWGLDALYWDNERNRLLTVRTVRPSTGLDPHGLPGENASIQLVNFLAPTRRHPQTAHADYIDIRSAVQQTEPYSVDVAVNGTCHTATRIDVLALSVVELAWEDRTVFATGQPSLVDRLTLRSAHVADLTHLQPRQMPSHQDRHRFPPG
>CP015163.1|AXB44493.1|4302465_4302996_+|hypothetical-protein
MTTTTAAAPALRRLYFVRFGFALVWAVALFLTAASVGPVSATLLVLYPLFDVGAAVVDARSSRAGRSAPGLYVNIVISGLAAAGLAFAVTSGIPAVLRVWGVWAVTAGVVQLVVALRRRALGGQWPMITSGAISTLAGAAFFLQAADGSLRNLAGYALLGGVFFLVSALRLGRAAA
>CP015163.1|AXB44492.1|4301751_4302357_-|TetR-family-transcriptional-regulator
MATQTSGSSSGERSEARERLLSTASGLFYREGIRAVGVERILAEAPATRATFYRHFPSKEDLVVAYLRGVDADMRAGVLAAVEAAPSPADALRAIGAAVADSLASPEFRGCAFLKAAAEYPDPEDRVRKVILAHREWYTTTLTDLFGRVFGSDPRRGKPEHAARHFVMMRDGAMSGAHLDGVDSVGDAFRRGVEGLLTVLH
>CP015163.1|AXB48648.1|4301432_4301768_+|ArsR-family-transcriptional-regulator
MTGELAIPPIDEVELGTVLAALADPHRRRVVLELARGQDTERACASFALPKAKSTRTHHWRVLRGAGLIRQRDAGNGTFVRLRDEFENRFPGLLSLLSNLDRGDPPLSEGR
>CP015163.1|AXB44491.1|4300736_4301351_-|haloacid-dehalogenase
MLCVFDVNETLLDLAPLDEVFGSADARRAWFARVIHTALTVTATGGYRDFAAIAGAAADERHRAELGPVLRSLPAHPDVPSGLARLRDAGFTLVALGNSPLSVVETQLRNAGIRDHFDAVFSAEQAGALKPAAAPYRRVLDAYPGEDAMMIAAHGWDIAGAHAVGLRTAFIERPGQAQLPGGPEADLAAPDIDALATKLIEAGS
>CP015163.1|AXB44490.1|4300314_4300716_+|enamine-deaminase-RidA
MALERAAINPVPWSLELGFNQGELVAGQTRTLYCSGQTAMDGDGKPQHEGDVAAQLALSLDNLEAVLGGAGMTLANLVRLNVYTTDVDQLFPHYGVLAARLGAAGVSPTTTMLGVTRLAVPGQLVELEGTAVA
>CP015163.1|AXB44489.1|4299253_4300225_-|DNA-binding-transcriptional-regulator
MRADRLVSLVLLLRQRGRLTADALARELEVSTRTVLRDIDALSAAGVPVYAERGRHGGFALLPGFRTELTGLNHEEALALLTAGSGRGEQAFGLGSALASAMRKVVDALPEGHRSTASDAAQRFLVEPETDLLSRRPVVEEVPGAVMLEIRRAVLAGRKLRIHYAAAGQPPRWRTVDPIGLVTVRDRGYLLATRGGADRTYRLSRVLAAEELPEPAQRPNQVDLDRAWRERCAQFLSSDHIAVLVRVKPARREQLLSTAVAVRAAEPDDDGWLRLEATFQDLWHAEWALWQLGTDAEALTPQELRASLHDRAAAIAARYRGSP
>CP015163.1|AXB44498.1|4309004_4309784_-|HAD-family-hydrolase
MEFALAPPRQRRTTPASPADPWSAPALRLVCLDIDDTLIDFTASSSGALAAVLGRDDLWPLWEAVTDRHVAMVVAGDLDYAAMHRTRTQSFLAEVGQPVCAEEAASFERRRLELLRRSWRLFDDVLPCLEWLRAAGVHLAAVTNASGAHQRTKLADLGLARFFDHIAIAGEMGVAKPDPVMFHTVCLALGCDPGEAVHVGDKLDTDAIGAHDAGLGAVWLDRAATGAAVPRGVHVVEGLAELPELLVCEFARVGVPAPR
>CP015163.1|AXB44499.1|4309864_4311352_-|glutamate--tRNA-ligase
MTETTPVRARFCPSPTGAPHVGMIRTALFNWAFARHHGGTLVFRIEDTDAARDSEESYESLLEALRWVGLDWDEGPEVGGEYGPYRQSLRREIYADVAAKLLEAGELYEAFSTNEEVEARRKAAGQDPKLGYDNFDRDLTDEQRAAFRAEGRKPVLRLRMPDQDLGWTDLVRGEISFPAATIPDPVLVRNNGEPLYTLTNPVDDALMKITHVLRGEDLLPSTPRQIALYAALQRIGVAERTPEFGHLPYVMGEGNKKLSKRDPSSNLFNLRDRGFIKEGLVNYLALLGWSIADDRDIFTAGELVEAFDIGKVSANPARFDLKKAEAINGTHVRALDVDDFTARVVPYLQLANVLPAEPSESELSRLRAIAPLVQERVIVLSDTVDMVRFLFVSEEEFAPEEAAAAKVLGPDAEPVLRAAIEALEELSSWDTPGIEEALKNALVEKLGLKPRKAFAPVRVGITGRTVSPPLYESMELLGREVSLGRLRRALDGVGL
>CP015163.1|AXB44500.1|4311451_4312705_+|hypothetical-protein
MTERTGCVVIGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPSTLQLLDELGLGERFHAVPHSEIQQVGFPLPDGRMLTFADLSRLKVKYPYIAMVPQWDFLDVLAEAGRDEPSFTLRMSTEVTGLVAEGDRIAGVRYRTADGTEGELHADLTVAADGRWSLARRQAGLRPREFDVPFDAWWFRLPRHDGERGDTISPQMRNRKFAVALPREGYFQIAYLAPKGSDEDLRNAGIEQFRASVAEAYPNYADRLDSLETMDDVKFLDVRLNRLHRWHTEGLLCIGDAAHAMSPIGGVGINLAVQDAVATAHLLAAPLRRGRPRQRDLAKVRARRWLPTVAVQLLQRLLHRAVMRPVMAGKRNGPPKPVIAVLGRFPKLAVVPAYLIGVGLRPEHAPGFARRDPVSPAPRGS
>CP015163.1|AXB48649.1|4312679_4313453_-|2-hydroxyhepta-2,4-diene-1,7-dioate-isomerase
MRLARIAHPGGVAFAAIEGDGDDAQVLEIAEHPFGDPNFTGKRWPLADVRLLAPILPSKVIAVGRNYAKHAAEFGNEVPQSPMLFLKPSTSVIGPNAAIKLPPAAGRVDFEGELAVVIGQPVKNVPAARAASVVLGYTVANDVSARDLQKADGQWGRAKGYDTFCPLGPWIETKLPDPGNLSLKSEVDGQLKQDGTTADLIHKIPELVEFVSSVMTLLPGDVILTGTPEGVGPITDGQQVSITVEGIGTLTNPVVQG
>CP015163.1|AXB44501.1|4313463_4315071_-|citramalate-synthase
MTRTEPAGTALGDEFHLYDTTLRDGAQREGISYSVTDKLAVARLLDELGVGFIEGGWPGALPKDTEFFAKAAGELSLKHAVLVAFGATRKAGTSAEKDAQVRALLDSQAPAVTLVAKSDLRHIERALKVEVAEACEMVRDTVEFLVREGRRVFVDLEHFFDGYAVSPDTALRVADAAAGAGADVVVLCDTNGGQLPLGLAETVREVKDRTGFRLGIHCQDDTSCAVANSIAAVQAGATHVQCTANGYGERAGNADLFAVTGNLVTKLGMEVLPTGNAAELTRVSHALAEIANIAPYAHQAYVGASAFAHKAGLHASAIKVDPLLYNHIDPPSVGNDMRVLVTEMAGRASLELKGRELGVDLAGRPEALTSAVRKVKRLEAEGWSFEAADASLELLLRREAGEAFDEPPFVLESYRVVLDHRADGEIVSEATVKVHVGGQRVIATAEGNGPVHALDAALREALTPHLSWLDSVELADYKVRILPGHPGTDAVTRVLVETTDGSREWTTVGVHGNIVEASWLALCDALVHKSLRLTT
>CP015163.1|AXB44502.1|4315302_4316340_-|3-isopropylmalate-dehydrogenase
MRLAVIPGDGIGPEVVTEALKVLGEVAPNAETTNYDLGAARWHSTGELLPESVLGELRQHDAILLGAVGDPTVPSGILERGLLLRLRFELDHHVNLRPARLYPGVRGPLADTAEIDMVVVREGTEGPYAGNGGLLRKDTEHEIATEVSVNTAFGIRRVVSDAFDRAEQRPRKHLTLLHKTNVLEHAGSLWSRVVEEVSLEHPDVTVAYSHVDAATIHLVTDPGRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNLDITRRNPSMFEPVHGSAPDIAGQALADPTAAVLSVALLLDHLGQKEAARRIEASVAFDLATRDQANPGSTHAIGDRLAALVSSNTRTA
>CP015163.1|AXB44503.1|4316612_4319948_-|peptidase-S8
MKRTRVPRWAARLSVVVLTAGFIGAPAASAQEAQDVPLADALPQSGAAGFAGKVEPRLGAAQGKVTAFVELAKRPAVDAFNAEQSKGAGKEKAKQAAKAAQAETEAAVDSVVGQLTSADAGTELLAETSTAVPGAVVTADAAKIRELAHRDDVVSVRTVVPKKRTNTSAVQLTQALNVWQQTGRYGDGIRVGIIDDGIDYTHADFGGPGTKEAYDAIDPTQVSPSFFPTAKVVGGVDLVGDEYDSGGEGDVTVPKPDPNPISCGHHGTHVAGTAGGFGVNADGTTFTGDYSKLTPESVAQMRIGPGTAPKALLYAIKVFGCDGSTNVTTEALDWALDPDRDGDPTDKLDLVNLSLGSDFGSPDDPDSLFVRKLAANNVLPVFSGGNGGDLYDVGGSPGNTPEALTVASTRDASVLRDAVDVVAPAGSTGQKGGQFSQNYADYDALDVTAPVVKVSAANAAGCAPFSAADKAAVQGKIAWLEWDDNDATRPCGSGARANNAQAAGAAGVLLSSTLENFAAGIAGNAAVPMFQLTGSATASVRPALDAGTLQVRMSGLGRSALQTFDQSIVDTPSSFTSRGVRGPSVKPDVAAPGDSISSAYSGSGNGRTVLSGTSMAAPHTAGITALIRQAHPDWSVEEVKAAVVNTAGTDVVEGGKTFGPQRVGSGRVNAKSALDNQVLAYVQDNPGVVSASFGTVEAAGPVSLTKTIKVVNKGVKPVEYGVAYQGVTQLPGVRYELNKNSVKLSPRGIATVTVTLKIDDPKALRKVIDPTMQTTQAGLARQFLADASGRVAFTPRNGATVGLRVPVYAAPKPVAGITTPAKVTFPAGQQQAVVNLGGRGVSQGAGAQAYRSLVSMFELQAQSPQLPECDDQPTQCTINDTAKGGDLKYVGAASTAPLAKQQGAPEESLLAFGIATWSNWANLGSNTIPFVDIDTTGDGRPDFESYVTKATSSDVLLVNTVDLNKPGFPSVDLQPLNGHLGDVDTNVFDTDVAVLPVRLAALGIDPNADSHRISYTVGVAGYYTAPGSGVIDSVDTPLSFDAVSPGYWVQGGGDAALSYLARPGTALVVNRNAASAGQDTVLGLLALNHHNASGNRANVVQLNVAPPAADS
>CP015163.1|AXB48650.1|4320242_4321841_-|phosphoglycerate-dehydrogenase
MTTPSKPVVLIAEKLAPSVLSVFGDEVDVQHVDGTDRPALLEAVKGADALLVRSATKVDAEVLAATSRLKVVARAGVGLDNVEVPAATERGVLVVNAPTSNIVSAAEHAVALLLAVARRVPAADQSLRGGEWKRSAYSGVELNGKTVGVVGLGKIGQLFAQRLAAFGTTLIAYDPYVSAARAAQLGIELVSLDELLARADAFSIHLPKTPETKGLIDAEALKKTKPGVIVVNAARGGLVDEEALAAAIREGHVGGAGVDVFATEPTTASPLFELPNVVVTPHLGASTAEAQDRAGTDVARSVLLALRGDFVPDAVNVSAGGPVGEEVRPYLSLTQKLGTVLASLNPKAPATLTVHVRGELADEDVSILPLAAERGVFAGVVRDPVTFVNAPRLAEELGVRVELTKEPESPNHRSLVTVRAVHADGSTLSVSGALTGKDEVEKLVEVNGRSFDLRAEGNLLLLEYPDRPGIMGRVGTLLGEAGINIEAAQISQTTDRTDAVMLLRVDRAVDQHVLEPIGTVVQASTIRAISFG
>CP015163.1|AXB44504.1|4322007_4322574_-|TetR-family-transcriptional-regulator
MTSAKPLRADARRNYDRLLAEAATAFARDGVDASLEEIARAAGVGIGTLYRHFATRSALLEALLRDRFDRVAELGRELIEHDRPGEALFRWLRELAAVSTTFRGLIEAVAVALRDETSELYESCHTMRGTGARLAERARAAGELREDVATEDMLLLVNAVAWASQHDPAGDARVPELLELVFSGLRPS
>CP015163.1|AXB44505.1|4322663_4323557_+|LLM-class-F420-dependent-oxidoreductase
MELIERTRAALGAVGIWLPNAPLKPPVEVERRETRRLDTLGYGSLWSGEGVGVREALAIHGILLGDTRNLVFGTGIANVWSRPASTLQAGAATLAAAHPGRFVLGVGIGHAFQAARTGGDYRPLSQLRDYLSTMDAEAAENPPAEAFPRVLAAVGPRMLELARERTEGAHPFFTPVEHTAFAREVLGPDKLLIPQLHVLLETDPVRARESQHDWLGYALGVKAYANAWRRFGYEPGLSDRFIDAAVAWGDEEAIARRVREQLDAGADHVLVTPSVGSLPEQADMLEKLAPALLEVAR

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Crispr_ID: CP015163_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP015163_7

5504896-5504999

Orphan

Consensus_repeat	Method
AACGTGCCCAGCCCCCATCCAAAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP015163_7

>merge|CP015163|7|5504896-5504999|CRISPRCasFinder
AACGTGCCCAGCCGACCATCCAAACCAAACGTGCCCAGCCCCCATCCAAACTCAACGCGCCCAGCCAACCATTCAAACTCAACGTGCCCAGCCGCCATCCAAAC

>CP015163|7|6|5504896-5504999|CRISPRCasFinder
AACGTGCCCAGCCGACCATCCAAA	CCAAACGTGCCCAGCCCCCATCCAAACTCAACGCGCCCAGCCAACCATTCAAACTC
AACGTGCCCAGCCGCCATCCAAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP015163.1\|AXB45453.1\|5508532_5509198_-\|urease-accessory-protein-UreF	unknown	unknown	gnl\|CDD\|223900
CP015163.1\|AXB45440.1\|5493871_5494474_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
CP015163.1\|AXB45450.1\|5506521_5507139_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
CP015163.1\|AXB45451.1\|5507125_5507836_-\|urease-accessory-protein-ureD	unknown	unknown	gnl\|CDD\|376611
CP015163.1\|AXB45441.1\|5494549_5495698_+\|acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
CP015163.1\|AXB45455.1\|5510918_5511212_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|376370
CP015163.1\|AXB45442.1\|5495786_5496386_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99749
CP015163.1\|AXB45447.1\|5500900_5502127_-\|MFS-transporter-permease	unknown	unknown	gnl\|CDD\|340863
CP015163.1\|AXB45454.1\|5509197_5510916_-\|urease-subunit-alpha	unknown	unknown	gnl\|CDD\|237304
CP015163.1\|AXB48789.1\|5505163_5506270_-\|lipase	unknown	unknown	gnl\|CDD\|367570
CP015163.1\|AXB45457.1\|5511771_5512920_+\|citrate-synthase	unknown	unknown	gnl\|CDD\|237070
CP015163.1\|AXB45444.1\|5497610_5498516_-\|aldose-epimerase	unknown	unknown	gnl\|CDD\|185699
CP015163.1\|AXB45452.1\|5507832_5508543_-\|urease-accessory-protein-UreG	unknown	unknown	gnl\|CDD\|349776
CP015163.1\|AXB45449.1\|5503123_5504791_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224374
CP015163.1\|AXB45446.1\|5499452_5500841_-\|amino-acid-permease	unknown	unknown	gnl\|CDD\|129987
CP015163.1\|AXB45443.1\|5496370_5497585_-\|amidohydrolase	unknown	unknown	gnl\|CDD\|238634
CP015163.1\|AXB45445.1\|5498571_5499396_+\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293828
CP015163.1\|AXB45448.1\|5502236_5502926_-\|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl\|CDD\|273138
CP015163.1\|AXB45456.1\|5511224_5511527_-\|urease-subunit-gamma	unknown	unknown	gnl\|CDD\|376347
CP015163.1\|AXB45458.1\|5512996_5513617_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228

Protein	Function_ID	Function_description	E-value
CP015163.1\|AXB45453.1\|5508532_5509198_-\|urease-accessory-protein-UreF	gnl\|CDD\|223900	COG0830, UreF, Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones].	3.10307e-23
CP015163.1\|AXB45440.1\|5493871_5494474_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	0.000486842
CP015163.1\|AXB45450.1\|5506521_5507139_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	8.05211e-11
CP015163.1\|AXB45451.1\|5507125_5507836_-\|urease-accessory-protein-ureD	gnl\|CDD\|376611	pfam01774, UreD, UreD urease accessory protein. UreD is a urease accessory protein. Urease pfam00449 hydrolyzes urea into ammonia and carbamic acid. UreD is involved in activation of the urease enzyme via the UreD-UreF-UreG-urease complex and is required for urease nickel metallocenter assembly. See also UreF pfam01730, UreG pfam01495.	3.78173e-28
CP015163.1\|AXB45441.1\|5494549_5495698_+\|acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	1.45229e-169
CP015163.1\|AXB45455.1\|5510918_5511212_-\|ABC-transporter-permease	gnl\|CDD\|376370	pfam00699, Urease_beta, Urease beta subunit. This subunit is known as alpha in Heliobacter.	6.47527e-60
CP015163.1\|AXB45442.1\|5495786_5496386_+\|hypothetical-protein	gnl\|CDD\|99749	cd06260, DUF820, Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of nucleases.	1.94094e-21
CP015163.1\|AXB45447.1\|5500900_5502127_-\|MFS-transporter-permease	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.84306e-54
CP015163.1\|AXB45454.1\|5509197_5510916_-\|urease-subunit-alpha	gnl\|CDD\|237304	PRK13206, ureC, urease subunit alpha; Reviewed.	0
CP015163.1\|AXB48789.1\|5505163_5506270_-\|lipase	gnl\|CDD\|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	3.36558e-50
CP015163.1\|AXB45457.1\|5511771_5512920_+\|citrate-synthase	gnl\|CDD\|237070	PRK12350, PRK12350, citrate synthase 2; Provisional.	0
CP015163.1\|AXB45444.1\|5497610_5498516_-\|aldose-epimerase	gnl\|CDD\|185699	cd09022, Aldose_epim_Ec_YihR, Aldose 1-epimerase, similar to Escherichia coli YihR. Proteins similar to Escherichia coli YihR are uncharacterized members of aldose-1-epimerase superfamily. Aldose 1-epimerases or mutarotases are key enzymes of carbohydrate metabolism, catalyzing the interconversion of the alpha- and beta-anomers of hexose sugars such as glucose and galactose. This interconversion is an important step that allows anomer specific metabolic conversion of sugars. Studies of the catalytic mechanism of the best known member of the family, galactose mutarotase, have shown a glutamate and a histidine residue to be critical for catalysis; the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen.	4.43995e-125
CP015163.1\|AXB45452.1\|5507832_5508543_-\|urease-accessory-protein-UreG	gnl\|CDD\|349776	cd05540, UreG, urease accessory protein UreG. UreG is one of the four accessory proteins of urease. Urease is an enzyme which catalyzes the decomposition of urea to form ammonia and carbon dioxide. Bacterial urease is a trimer of three subunits which are encoded by genes ureA, ureB, and ureC. Up to four accessory proteins (ureD, ureE, ureF, and ureG) are required for urease catalytical function. UreG may play an important role in nickel incorporation of the urease metallocenter. UreG is a member of the Fer4_NifH superfamily which contains an ATP-binding domain. Proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.	2.08832e-104
CP015163.1\|AXB45449.1\|5503123_5504791_+\|hypothetical-protein	gnl\|CDD\|224374	COG1457, CodB, Purine-cytosine permease and related proteins [Nucleotide transport and metabolism].	2.03012e-22
CP015163.1\|AXB45446.1\|5499452_5500841_-\|amino-acid-permease	gnl\|CDD\|129987	TIGR00909, putative_amino_acid_transporter, amino acid transporter. [Transport and binding proteins, Amino acids, peptides and amines].	7.75375e-48
CP015163.1\|AXB45443.1\|5496370_5497585_-\|amidohydrolase	gnl\|CDD\|238634	cd01309, Met_dep_hydrolase_C, Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The function of this subgroup is unknown.	1.63458e-146
CP015163.1\|AXB45445.1\|5498571_5499396_+\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293828	cd07742, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.32433e-124
CP015163.1\|AXB45448.1\|5502236_5502926_-\|pyridoxamine-5'-phosphate-oxidase	gnl\|CDD\|273138	TIGR00558, Pyridoxine/pyridoxamine_5'-phosphate_oxidase, pyridoxamine-phosphate oxidase. This model is similar to Pyridox_oxidase from Pfam but is designed to find only true pyridoxamine-phosphate oxidase and to ignore the related protein PhzG involved in phenazine biosynthesis. This protein from E. coli was characterized as a homodimer with two FMN per dimer. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine].	6.27994e-104
CP015163.1\|AXB45456.1\|5511224_5511527_-\|urease-subunit-gamma	gnl\|CDD\|376347	pfam00547, Urease_gamma, Urease, gamma subunit. Urease is a nickel-binding enzyme that catalyzes the hydrolysis of urea to carbon dioxide and ammonia.	2.06315e-64
CP015163.1\|AXB45458.1\|5512996_5513617_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.7756e-12

>CP015163.1|AXB45449.1|5503123_5504791_+|hypothetical-protein
MTETVPTRKTTPPKRRYAKLAANENREDYSLRFAAHSFRRWRPAVVATTALGGIAYLADFAIGASIVFSYGFTSGVLAILAAALVIFVTGTPIAAACAKYGVDMDLLTRGAGFGYFGSTLTSLVYASFTVIFFALEGSIMAQAFDLALGVPLPVGYLLSTLIVLPFALYGMGALAKMQTWTQPLWIVGLVLPFVVVAVREPGRLAEFASFGGTEGAGSQFSAIGFGFGMGVALSLIGQIGEQADYLRFMPEKTAENKRSWWAAVLAAGPGWVILGAAKQIGGALLAFLALGAVGEAHALEPIAPYLEAVKPALGPVALTFAALFVVVSQIKINATNAYSGSLSFANFFSRVLHRHPGRVWYVLVNCGIALALMEFGAFALLNKILGFYSNVAIAWIGAVCADLLIVKPLGWSPRYVEFKRAYLHKVNPVGFGSMVFASAVSITAYFGAFGEFLAAFSPLLALVIAVVCVPLLAWLTGGRYYLARPNTVQTGELRATHNCTVCGDAYELPDIADCSRQQGAICSLCCTLDATCHDECQKPGASPTSLPMPTFHPPT
>CP015163.1|AXB45448.1|5502236_5502926_-|pyridoxamine-5'-phosphate-oxidase
MPELDNANGAADVGDVAIRLPGMRVAYEGESLDEESLAPTWTEQLQSWLDQAISAGVAEANAMVLATADGDGRPSSRTVLCKGLDQRGVVFYTNYTSNKSHDLTVTRYASATFPWYPLHRQVHVRGEVEKVDITETAEYWASRPRGSQLGAWASPQSRVVDGRRALDNALHAIERRFADVEQVPFPPHWGGWRIRPDVVEFWQGQRDRLHDRLRYVRTDDGWKIERVAP
>CP015163.1|AXB45447.1|5500900_5502127_-|MFS-transporter-permease
MDTRPLRIPAFRRLWLTTVVTAIGSQLTAVAVPKQVFDLTGSSGYVGLTGAVALVPLLVFGLWGGAIADTVDRRKLLMVTNTGIAVTAALLWAQAFFAVNSVWVVLVLLGVNQAFFAINMPTRSAVVARLVPEELLPPAIALQSTMSQFGAVFGPLAAGALLPVVGLSTLYLFDTVALALTLWAVWKLPAMLPLSGQVRRAGLRDVLDGFRYMATQKVLLASFVVDVIAMVAGMPRALFPEMAERTFGDPPGGGLALGWLYTAIPLGAMLIGLMSGWLTRISRHGVAVVVSIAAWGLCVFAFGLADSLWLAIVFLALAGAADMVSAIYRMAILQAASTDEMRGRMQGALTVVVAGGPRIADLSHGWAAAGVGTAVATSGGGLLVIALLVVAVMLLPAFWRYRAPVAKT
>CP015163.1|AXB45446.1|5499452_5500841_-|amino-acid-permease
MADTTTTEPETGPAGQPSLKRVMGSKLLLFFVVGDIIGTGVYALTGQVAGRVGGALWLPFLLAFVVAFMTAFSYLELVGKYPQAAGAALYTHKAFKIRFLTFMVAFAVMCSGITSASSAAKAFGDTYLAEFITAPMPLVAILFVIGLALINFRGVAESVKTNVVLTCIEIGGLLIIIGVGVWAVLNGNGDASRLTQFDTENQTMLVAITSATSLAFFAMVGFEDSVNMAEECKDPIRIFPKAMLWGMVIAATIYILVSVTSSLLVPADDLEAAKSSALLKVLDVGAPGFPREVFSAIGLFAVINSALINMLMASRLLYGMANQRIIPKQLGTVHPFRRSPWVAIVFTSLIAIGLVSFVDIGVLGGTTALLLLVVFAIVNVAVLVLRKEKAAHKHFRAPTVIPVLAAIFCVYLVTPLSGRPARDYTVAAILLAVGLVLWGINWLIMRATHSEADRQPLEPPVG
>CP015163.1|AXB45445.1|5498571_5499396_+|MBL-fold-metallo-hydrolase
MKVHHLNCGTFRPTGGRLVDGQGGAAHRARLVCHCLLIETGNGLVLVDTGLGLQALEQPGPWMGPSRWLLSATPRREETAAQQITDLGYALGDVRDIVLTHLDFDHAGGLADFPHATVHVYEREHRALTAPANATERLRYRHAQFEHGPKWRTYAEPGEDWFGFRAVRELPGLPPEILLVPLAGHTMGHAGVAVDTGNGWLLHAGDAYFFHGQLNPGQPHCPPVLTAFQTFTQTNRRARLENLGRLRDLAIGHRDEVTVFCAHDPLELRQAQRP
>CP015163.1|AXB45444.1|5497610_5498516_-|aldose-epimerase
MANPTGAQFEITRGGARAVVTEIGAGLRAFEVGGVPFLETFGEDEKPPKGAGQVLLPWPNRTKAGQWVYQGEKQQLEVTEEKRGNAIHGLTRREEWELLEHAESSITMAVDVPEQPGWPVPLRATTTYEVAPRELTVTHEIRNEGESAIGVGLGTHPYFRIGDTPTDDLTLTLPATRVRPYDADAQLPYKEEQDVEGTEYDFREGVILGGVDLDTAFGGLTTEADGNHHFRLSHEDRQLDIWAGPDFKWVQVFTPAELVGRGRGVAIEPMTCPADALNSGTDLIELSPGESWTGSWGIRVS
>CP015163.1|AXB45443.1|5496370_5497585_-|amidohydrolase
MVSAIVGGYVVPVDGDPIDGGTVLIEGGKIAAVGAEADVDVPEDAELIDASGSWVLPGFIDAHAHLGVHEEGEGWSGNDVNEMTDPNGARFRALDGIDPTETGFDDALAGGVTSAVIKPGSGNPIGGQTVGVKTWGRTALDMVFAERVSVKSALGENPKRVYGDKSQTPSTRLGVAAVLREAFTKARNYAAQREHARAEGKPFETDLTKEVLAKVLDGELYWDQHVHRADDMVTAIRLADEFGYRLVINHGTEGHLIADLLAEREVPVILGPLFTTRSKVELRNRTLRSAGILARAGVKIAITTDHPVIPINFLVYQAALAVKDGLDPETALRSLTVNPAEMLGLDDRVGSLTPGLDADVVIWSGDPLDVMNRAMRVFVRGRQVYHFDEASGEGVVAPRRYRES
>CP015163.1|AXB45442.1|5495786_5496386_+|hypothetical-protein
MTALPEPIPQPLEVDHLLTVAEYAALGETEHGYTELQEGRLVMSPSPRPAHNHACGELYVQLRSQLSEEWRALQDIDIDLELAGPDEPGFSRRPDLIVAGLDGIRRAEESGRLISAKDVLIVVEIVSPGSRRTDTVIKHGEYADAGIPHYWIVDLTEPVSLTACHLAEGFGYQNAPEVSGRTTLPEPFPLEIDLGQLSR
>CP015163.1|AXB45441.1|5494549_5495698_+|acyl-CoA-dehydrogenase
MPAERLLPTTEAEDLVALAREIARDELAPLAGEYEEAARFPREQFALLGKSGLLGLPYSERWGGGEVPYEVYLQLLEEIASAWMSVGVGLSVHTMSCFALAHHGTDAQRDRWLPEMLEGGLLGAYALSELQAGSDAAALSTRARLDGSEYVVNGTKAWITHGGEADFYTTMVRTSDEPGSAGISCLLVDGSTPGLSASAPERKMGLNGSTTAQMRFEDARVDASRLIGPEGHGLKIALASLSSGRLGIAACAVGLAQAALDEAVAYAKGRTQFGRSIIEFQGVEFLLADMAAAVESSRAMYLDAARRRDRGLPFQRQASIAKLVATDAAMKVTTDAVQVLGGAGYTRDFPVERYMREAKVPQIFEGTNQIQRVVIARELRKA
>CP015163.1|AXB45440.1|5493871_5494474_-|TetR-family-transcriptional-regulator
MADVDARARAPRRQPTARQRALLADLEELFLAEGFAEFTLDDLATRMRCSKSTLYALAPSKEQLAVKVVGRFFRGAAERIEASIADLTDARELIGTYLDGAAEHLKRASPAFMRDIAEFAPARAAYELNSRAAAERIRGFINKGVRDGVFRTVQATLIAEMAGLIIEGIQTGVIASRVQVSDAEAFTALSELLLGGLAAG
>CP015163.1|AXB48789.1|5505163_5506270_-|lipase
MPSQDPFYTPPDQLTGSPGDVLRQRAVDVKVGPFPAPVKAWQLLYRSTSATGEANAVSGTLLVPPVPWANGPRPLLTYAVGTHGIGDSCAPSYKLRTGTENEVALIGQALGKGWAVVLTDYEGLGTPGTHTYATGQSEGRAMLDAARAAFTVGEAGLSPDAPVGVFGYSQGGQAAAFAGELHPSYAPELKVAGVAAGGVPADLNEVAKFNDGGPAFGLVLGAATGLATAYSDVPFESILNDRGRSVVARIQDACTIELGAAAPFGRLADFVTVEDPLGDPRWQVRLAENRAGERAPTAPVFLYHGTLDELIPFRVGKDLLSRYCGAGVKVQWRAFPLVEHIGGVAVGGPVAMEWLGSRFAGNVAGSSC
>CP015163.1|AXB45450.1|5506521_5507139_+|TetR-family-transcriptional-regulator
MVRTYGGVAPEQRRAERREKLLTAALERFTADGYAQTKIARLCAEAGVSTRNFYEEFSSKEQVLLTLHARINEAAYQRVSAKLDELGELDAVTRISAALDVFVATVTSDPRLPRLNYVEAVGVSPELERQHQDWVTRWAEFIAAEAERAARHGLAPARDYRLTSIALVGAATGLLREWQAHEPPLPVEDIAAELKGVMLAAITRQ
>CP015163.1|AXB45451.1|5507125_5507836_-|urease-accessory-protein-ureD
MKATARLVAERDTTGRTVLRELRSMAPLTLFPRRRRAPDALVHLVNSATSPLGGDELRLEVRVGAGARLTLSGVAATLALPGPLGEASSSIVEVEVEAGGRFVYLPEPTVVTAGARHVAELRVSLAGDAEFRAREVLVLGREGEAPGRLTSTQHVVRAGRAVLRQTLDIGDPALGASLAYLAGRRVLATEILLLEGKPVEPGGGEWWSVSPLAGGGAQVTALADSTVDAERMLTGA
>CP015163.1|AXB45452.1|5507832_5508543_-|urease-accessory-protein-UreG
MPAEGHGHGHGHVHPVNFDPTATEPDQFPAASMDGRPYRIGIGGPVGSGKTALVAALCRALGDELNLAVVTNDIYTTEDADFLRRAGVLDPARIEAVQTGACPHTAIRDDITANLDAAERLEERFPGLDLIIIESGGDNLTAVFSRGLADSQVFVVDVAGGDKVPRKGGPGVTTADLLVINKIDIAHLVGADMAVMTADAHRMRGELPVITQSLVDTPDAPAVADWVRSLVPARAG
>CP015163.1|AXB45453.1|5508532_5509198_-|urease-accessory-protein-UreF
MDVSALIMADSRFPGGGHVHSGGLEETVVRKLVRTERDLPSFLSGRLHTAGALAASFAAAACRQSDWALLDTELDARTPSSAQRESSRAQGRGTVRAGKVAWPSPVLDELLRVTPRPHHPIAVGALTGIAGGTPLDAALAVAYLAVSGPASAAVRLLGLDPFVVNAVVARLSGELHAVAEAAASVAGEHPAELPAPGAPALDLLAEAHWRGHKEEVRLFAS
>CP015163.1|AXB45454.1|5509197_5510916_-|urease-subunit-alpha
MPQIDRERYAELFGPTVGDRIRLADTDLLIEVTEDRSMGAASGDEVLFGGGKVIRESMGQGMATRAEGAPDLVITGVVVLDHWGVVKADVGVRDGRIVGIGKAGNPDTMDGVDPALVIGPATEVLAGNGKILTAGGIDCHVHFICPQLVDTALAAGLTTLVGGGTGPAEGSKATTVTPGAWNLGRMLRAMDQLPINVLLLGKGNTVRTEALREQLAAGAGGFKLHEDWGSTPAAIDACLTVADESGVQVAIHTDTLNEAGFLESTVDAIGGRSINAYHTEGAGGGHAPDIIQVAGLPNILPSSTNPTRPHTANTLDEHLDMLVVCHHLNPSVPEDLAFAESRIRPTTIAAEDVLHDLGAISMMSSDSQAMGRIGEVVIRTWQTAHVMKRRRGALPGDGAADNLRARRYVAKYTINPAIAHGMEAEIGSVEVGKLADLVLWEPKFFGVRPHVVLKGGFAAWAAMGDANASIPTPQPVLARPMFGASPVVAAETSLTFVAGEAIDAGIAERLRLTSGVVPVANTRRRGKADMVLNDALPDIRVEPDSFAVYVDGDLIEPQPVTELPMAQRYFLF
>CP015163.1|AXB45455.1|5510918_5511212_-|ABC-transporter-permease
MRPGEIITGDQPVELNPGRDRVTLRVRNTGDRPVQVGSHYHFAEVNPALDFDKEQAAGRRLDIPAGTSVRFEPGVEREVTLVPIAGRGVVPGLRRKD
>CP015163.1|AXB45456.1|5511224_5511527_-|urease-subunit-gamma
MHLSPQERDKLLVHVAADVARRRLERGVKLNYPEAVALITDHVLEGARDGRTVSELVASGRTVLSREQVQPGIAEMVDSVQVEATFPDGTKLVTVHDPIV
>CP015163.1|AXB45457.1|5511771_5512920_+|citrate-synthase
MTTAPVSPAPAPADETDDGFRPGLEGVVAFRTEIAEPDRDGGALRYRGVDIEDLAGKVTFGDVWGLLVDGRFGQGLPPAEAFPIPVHTGDVRVDVQAALAMLAPIWGYQPLLDITDEEARDQLARASVMALSYVAQSARGIGQPAVPQSRVDEAATITERFMVRWRGEPDPAHVKAVDAYWVSAAEHGLNASTFTARVIASTGADVAAAMSGAIGAMSGPLHGGAPARVLPMIAEAERTGDARAVVKGILDRKERLMGFGHRVYRAEDPRARVLRRTCQELGAERYEVAAALEQAALTELRERRPDRAIETNVEFWAAVILDFAQVPLHMMPAMFSSARTAGWAAHILEQKKTGRLVRPSAKYVGPGPRQPEEVEGWASLNR
>CP015163.1|AXB45458.1|5512996_5513617_-|TetR-family-transcriptional-regulator
MSREARRDDLIAAALDLFSTSPPERVSVDDIAARADVSRPLFYRYFSSIRELQVAALRTVTDGLIDRLAVDAEGEPLDRLRAVVRGLIAVADEYRAGYIALLRSGSVIATSETEALVDQVRNRAVELILAELGVAEPSPLLLVTLRCWTAVVEGTLLSWLQEGALPRDELDTWLVDQLVAMLTVTATHDPATVSFASPPARRGGRR

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Crispr_ID: CP015163_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP015163_9

5878718-5878829

Orphan

Consensus_repeat	Method
GGGGCCGGGTGTCACGAATGTGGCTTTCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP015163_9

>merge|CP015163|9|5878718-5878829|CRISPRCasFinder
GGGGCCGGGTGTCACGAATGTGGCTTTCGAGACGTTCTGCGTCCCGAATGTGGCTTTCGTGACACGGAGCCGGATCAGTCGAGGGGGCCGGGCGTCACGAATGTGGCTTTCG

>CP015163|9|8|5878718-5878829|CRISPRCasFinder
GGGGCCGGGTGTCACGAATGTGGCTTTCG	AGACGTTCTGCGTCCCGAATGTGGCTTTCGTGACACGGAGCCGGATCAGTCGAG
GGGGCCGGGCGTCACGAATGTGGCTTTCG

Protein	Signature genes	Signature genes Name	Protein_function
CP015163.1\|AXB45758.1\|5877842_5878280_-\|HxlR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
CP015163.1\|AXB48840.1\|5873567_5875199_-\|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173858
CP015163.1\|AXB45757.1\|5877216_5877858_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
CP015163.1\|AXB45765.1\|5888889_5890026_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB45766.1\|5890025_5890556_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB45760.1\|5878875_5881158_-\|DNA-polymerase-III-subunit-gamma/tau	unknown	unknown	gnl\|CDD\|236090
CP015163.1\|AXB48841.1\|5875391_5875991_-\|uridine-kinase	unknown	unknown	gnl\|CDD\|235825
CP015163.1\|AXB45755.1\|5875990_5876587_-\|recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
CP015163.1\|AXB45752.1\|5870526_5871528_-\|dipeptide/oligopeptide/nickel-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223521
CP015163.1\|AXB48844.1\|5887100_5888471_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB45763.1\|5885154_5886303_+\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
CP015163.1\|AXB45754.1\|5872460_5873465_-\|peptide-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
CP015163.1\|AXB45753.1\|5871534_5872464_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
CP015163.1\|AXB45759.1\|5878278_5878710_+\|PPOX-class-F420-dependent-enzyme	unknown	unknown	gnl\|CDD\|274679
CP015163.1\|AXB48843.1\|5886335_5886965_+\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107
CP015163.1\|AXB45764.1\|5888467_5888878_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379037
CP015163.1\|AXB45761.1\|5881308_5882847_-\|metallophosphatase	unknown	unknown	gnl\|CDD\|226070
CP015163.1\|AXB45762.1\|5884352_5885057_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|223816
CP015163.1\|AXB48842.1\|5882923_5884351_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
CP015163.1\|AXB45756.1\|5876596_5876962_-\|nucleoid-associated-protein	unknown	unknown	gnl\|CDD\|234669

Protein	Function_ID	Function_description	E-value
CP015163.1\|AXB45758.1\|5877842_5878280_-\|HxlR-family-transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.81539e-38
CP015163.1\|AXB48840.1\|5873567_5875199_-\|peptide-ABC-transporter-substrate-binding-protein	gnl\|CDD\|173858	cd08493, PBP2_DppA_like, The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold. This family represents the substrate-binding domain of an ATP-binding cassette (ABC)-type dipeptide import system. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	6.17035e-178
CP015163.1\|AXB45757.1\|5877216_5877858_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	2.43253e-45
CP015163.1\|AXB45760.1\|5878875_5881158_-\|DNA-polymerase-III-subunit-gamma/tau	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	0
CP015163.1\|AXB48841.1\|5875391_5875991_-\|uridine-kinase	gnl\|CDD\|235825	PRK06547, PRK06547, hypothetical protein; Provisional.	9.11341e-16
CP015163.1\|AXB45755.1\|5875990_5876587_-\|recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	2.94314e-112
CP015163.1\|AXB45752.1\|5870526_5871528_-\|dipeptide/oligopeptide/nickel-ABC-transporter-ATP-binding-protein	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.06897e-161
CP015163.1\|AXB45763.1\|5885154_5886303_+\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	5.45229e-28
CP015163.1\|AXB45754.1\|5872460_5873465_-\|peptide-ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	5.27726e-120
CP015163.1\|AXB45753.1\|5871534_5872464_-\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.16905e-86
CP015163.1\|AXB45759.1\|5878278_5878710_+\|PPOX-class-F420-dependent-enzyme	gnl\|CDD\|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	7.55517e-22
CP015163.1\|AXB48843.1\|5886335_5886965_+\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.58874e-65
CP015163.1\|AXB45764.1\|5888467_5888878_+\|hypothetical-protein	gnl\|CDD\|379037	pfam13115, YtkA, YtkA-like.	3.88427e-08
CP015163.1\|AXB45761.1\|5881308_5882847_-\|metallophosphatase	gnl\|CDD\|226070	COG3540, PhoD, Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism].	3.34255e-121
CP015163.1\|AXB45762.1\|5884352_5885057_-\|DNA-binding-response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	4.20341e-85
CP015163.1\|AXB48842.1\|5882923_5884351_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	6.81761e-54
CP015163.1\|AXB45756.1\|5876596_5876962_-\|nucleoid-associated-protein	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	4.77068e-37

>CP015163.1|AXB45759.1|5878278_5878710_+|PPOX-class-F420-dependent-enzyme
MKLPESTYRLFESTHHATVVTSNPDGTPQTSLVWAERDGDEILIGMEGTRPKARNLRRDPRVTLLIEDHENDEVRGLRQYLLLHGTATITGPGIPAEFDALMDAQARRYLGLPRYPFENRSSTTAVIARITATRITGNGPWAS
>CP015163.1|AXB45758.1|5877842_5878280_-|HxlR-family-transcriptional-regulator
MCSTLEIRRAPTGTLGTVGDFSGGADVFLADCPARLAVEIIADKWAVVVVFALSRGPRRHGDLIGLIGGISKKMLTQTLRRLERHGLVERQAYAEVPPRVEYRLTELGETLVEPIAVLTKWAETCGEAVVDAQERFDAGTAQPPR
>CP015163.1|AXB45757.1|5877216_5877858_+|N-acetylmuramoyl-L-alanine-amidase
MVVLDPGHNGGNAANPAAIKRQVPAGRGRSKPCNTTGTSTNDGYREHEFTFDVAQRVGKLLTDKGIRVVYTRSDDTSVGPCVDQRAEIGNSAGAAAVVSIHADGNTSPGANGFHIAYSAPPLNEAQGEPSSKLTHALRDSLRDTGFRYSDYLGEQGLSARDDLAGLNLSERPAALVECGNMRNATEAARMSTSDGRQQYAAGIAGGILSYLGG
>CP015163.1|AXB45756.1|5876596_5876962_-|nucleoid-associated-protein
MVQPGGGFDMQQILQQAQKMQEQLVSAQDELAKAEVTGTAGGGLVTAVVSGGLELKSLTIDPKVVDPEDTETLADLVVAAVRDATANAQKLTEEKLGPLAGGLGGGMPDLGGLGLPGLPGQ
>CP015163.1|AXB45755.1|5875990_5876587_-|recombination-protein-RecR
MYEGVVQDLIDELGRLPGVGPKSAQRIAFHLLGADPVDIGRLQEVLGKVKEGVQFCEICGNVSEQANCRICRDTRRDLSLICVVEEPKDVLAVERTREFKGRYHVLGGSLDPLSGIGPEQLRMRELLARIGGEEVKEVIIATDPNTEGEATATYLVRMLRDFPGLTVTRLASGLPMGGDLEFADELTLGRALSGRRAL
>CP015163.1|AXB48841.1|5875391_5875991_-|uridine-kinase
MAEQVLAGRPALGGVRLVAVDGPSGAGKTTLAGNLLAELTDRGADALGIGTDEFATWDDPVSWWPRLRDGVLRPFARGHRGGYRRMDWTSGAPVPGELITVRVPEVLVLEGVSSGRASVRAHLTCLAWLDGLDQATRLERAVARDGETERKHLSGWQEFELGWFAADRTADAATIRIESSAVRPFVPVGPKFATHSHHL
>CP015163.1|AXB48840.1|5873567_5875199_-|peptide-ABC-transporter-substrate-binding-protein
MALIGLSGALALSVTACAESQRDAGADNTGTFIFGAAGSPKMFDPIFNDEGETFRITRQMYDTLLQNKPGTAEVVGSLAEKWESSNEGKTWTFTLRKGVTFHDGTPFNAAAVCFNFDRWFNMKGQAAQSQMIYYGDVFEGFAQNEGDASGDPVYKNCEAKDDSTAVLNLNKAKGAFPAAFTLPSLSMSSPEALKKYNADQVTQTGDSFSYSDYANLHPTGTGPFKFEGYDQGKGEVTLVRNDAHWEKAKLEKLIFKVIKDENGRKQQLKTGDIHGFDYPAPADYQLLRNEGQNVLIRPSFNVLYLGINQAGNPKLQDVKVRQALAHGINREQFVKSKLAEGSEVATEFVPKAIAGYTEDVPKYPYDPEKAKQLLREAGAEGLTLKFYYPTEVTRPYMPNPADTFTSISEDLKAIGINIEPIAKPWNGGYKDDVQKLGKHDLHLLGWTGDYNDAGNFVGTFFGREKPEFGFKNQALFDALAAADATQGEGPHAKAYEGVNKQIMEYLPAVPIAYPTPALVVGPKVQGMVPSPLTDERFNTVSLG
>CP015163.1|AXB45754.1|5872460_5873465_-|peptide-ABC-transporter-permease
MLRFIVRRLLQAIPTLLILSILVFAWLRALPGGPAGALLGDKATPEKIAELNQVLGLDQPIFVQYFKFLGRVLTGDFGSSLISTQPVLDEIAFALPATIELSVAALLLAVGLGIPLGYVAARFRGGFLDNTTIMATLVGVAVPVFFLGYLLQFVFAEQLGWFPVGGRQDTLIGATDVTGFAVLDGLLTQEWDASWDAIVHLVLPAAALATIPLAVIVRITRASVLDVMNEDFIRTAQSKGLGAPTIRRRHVLRNALLPVATTIGLQTGLLLGGAVLTERVFNLNGIGSLLAEGIERRDYPRLQALILLGAVVYVLVNMLVDISYGIIDPRVRVR
>CP015163.1|AXB45753.1|5871534_5872464_-|ABC-transporter-permease
MTNLLTRKKDKVDGLAASAGHSLAQQAFRRMARSPVAITGAVITGLFLLLSIFAPFIAPKDPYERYLQGEVALGQGIIPGPREGFPLGVDDFGRDLLSRMLVGAQQTLLVGVMATLIGLAIGMVIGGIAGAFGGWIDTVLMRLVDVMLSIPSLLLAISIAALAAKPSQWTVIIAVAMVSVPIFARLLRGTMLAQRSSDHVLAATSLGVKRHTIVLRHMLPNSLGPVIVQATLTLATSIIEAAALSFLGLGDPDPTRAEWGLMLGKAARQFLDIRPELAFYPAIAIIIVALGFTLLGESMREALDPKNRR
>CP015163.1|AXB45752.1|5870526_5871528_-|dipeptide/oligopeptide/nickel-ABC-transporter-ATP-binding-protein
MALLEVRDLKVVFQRKGERPFTAVDEVSFDVEPGQTVGLVGESGCGKSVTSLAIMRLLAKRGNKVTGSVKFEGTDLLTLGEGEMRDRRGRDLGMVFQDPLSSLNPVIPIGIQVTEVLERHRGMSRKAAMVEAGDLLAKVGIPDPTRRLTEYPHQLSGGMRQRALIAIALACRPRLLIADEPTTALDVTIQAQILALLQELVRDTGTALIMITHDLGVVAGLCDEVNVLYGGKIVERAERHALFAEPRHPYTHGLLASIPRLDAGRGEKLVPIRGSVADNIPWDGGCAFAPRCPNALDTCRQVTPALEPDGPGLLRCHNPVQPRAAATAGEGTR
>CP015163.1|AXB45760.1|5878875_5881158_-|DNA-polymerase-III-subunit-gamma/tau
MALALYRKYRPATFAEVVGQEHVTEPLRTALAAGRINHAYLFSGPRGCGKTSSARIMARSLNCEQGPTPDPCGECGSCRALAPEGSGSIDVTELDAASHGGVEDARELRDRAFYAPAESRYRVFIIDEAHMVTTQGFNALLKIVEEPPEHLIFIFATTEPDKVLTTIRSRTHHYPFRLIPPSAMRELLERNVAAEGVPVEPAVYPLVIRAGGGSARDTQSVLDQLLAGAGPDGVTYERAVSLLGVTDVALIDDMVEGLAADDSTAVFGTVERLAEAGHDPRRFASDLLDRLRDLVVLRSVPDAAARGLVAAPEDELNRMVAQAERAGLATLSRYAEIVHNGLLEMRGATAPRLLLELLCARMLLPSAADGEAALLQRLERLERRVTVGGAPDGTAAAASPGTASPGGAASGGAERFQRPSQRQAAGASAAPAAAQPSAEAPSRPAPGQQASAASALGQQAPPAQQAPAASAPGQQPPAASAPAQQAPAAAPPAQPPTHPSGGQPSGGQAPAAQPPAPAASRQPVGQASGQQSGGQAGGQPQSGPSAAAQPSGQQGAAAGGMDAAAVRRVWPELLAAIRKIPGGRSTEAMLTQAGVQSVDGTSVVLTHTAEPLARRLADPHNSEKIASALRDVLGGEWRVTCVHGNAAAKPQPVQQQRQAPPQQAAEEKRFRRPSEGRPAPEPAPPAPPEPPRPKVTTAEPDIPLPPEPEDEEEYLDAATTPPPPNGSVPPPPPPPTPQVDEAEEKAHRLLSEQLGARPLD
>CP015163.1|AXB45761.1|5881308_5882847_-|metallophosphatase
MPLNRRDLLRGAAAAGALGVAWPLSGGLTLAQAEEAAAALGASWDEAPFTVGVGSGDPLPESVVLWTRLAPQPLAEEQPLPDTVEVEWVVATDTAFRHRVAHGSAPATAALGHSVHIAVTGLEPARRYYYRFRALGRTSRTGRTRTAPAGHVRRVRFASANCQAFHDGFYAAHRGIAHEDLDFVVHLGDYIYEHGQVGGDHVRDHEGPAVTTLPAYRRRHALYKGDPSLRAAHAAHPWFITWDDHEVVNDYSGTTPSLRARRDAGYQAWFEHLPVRPDHPATPQVYRQRSWGDLLDLSILDLRQYRSAQNLPDGTILGAEQKAWLKDRVSNAGNAWHCWVNSIMLSQLAKPGGGYYFTDQWDGFLAERREVLTHVHDTGLEDFVVITGDWHSAFVDDIRPDFDNPDAPVIGTEFTAHSVSSGAYSPEWNAENGPVMGGANPHLKYFEGNRYGYDVYEVTPRRWSTHLRVIGDRRDPNSPVSTLTTFHVDRGRAGSHEDRGTRTSPAQYRRDR
>CP015163.1|AXB48842.1|5882923_5884351_-|two-component-sensor-histidine-kinase
MRRPWSLRGRLIAQVVALLSLVCLVIGVVTEFALRDFLLERVDSQLTTFEDHPPPPGGLPGPRVRFELGQPKDTVFGVVYGGQVLDAKILGDGAATDLSASDAATFTGLTSPRRPVSITIGDLGEYRMQATTGPEGEIRFRALPLAEVNDTLWRLGWIFGGVALGGLVLAGGVAALTVRRTLRPLDRVAATAAKVAELPLDRGEPELPMRVSEVDTDTRTEVGKVGAALNRMLDHVSHALAARQRSESRVRQFVADASHELRTPLASIRGYAELTRRSTAELPPDFVYAMSRVESESTRMTTLVEELLLLARLDEGRPVVHAPVELSGLVADAVADAHVTGPDHRWLLELPAEPIRVIGEAGQLQQVVLNLLSNARAHTPAGTTVRTELSTKDGEVRLVVADDGPGIPEDVLPEVFERFARGDTSRSRAAGSTGLGLAIVAAVVAAHHGKVWVRSKPGKTEFCVVLPLLSVIGSP
>CP015163.1|AXB45762.1|5884352_5885057_-|DNA-binding-response-regulator
MTGVPGRAVRVLVVDDEPPLAELLSMALRMEGWEIRTAGDGTTAVRVAREFRPDAVVLDVMLPDFSGLEVIRRLRTEFEHLPVLFLTAKDAVEDRIAGLTAGGDDYVTKPFSLEEVALRLRALLRRARVVTAASDSLLTVGDLTMDEDTREVHRAGQPITLTATEFELLRYLMRNPKRVLSKAQILDRVWSYDFGGQANIVELYISYLRKKIDADRAPMIHTMRGAGYVLKPAS
>CP015163.1|AXB45763.1|5885154_5886303_+|two-component-sensor-histidine-kinase
MRDITGSLARQAWLIAVVCTVSDVSVALLIGPPLTGWRPWAVVLATMAADLALAGPARLSGLVALGHAVLYPLTPLLLNDLPGAEASNTAGMLIAGYRAGAWLSTLPAVAALLALLTGSVIGELLERNLAGRDWRLLSAILLANTVLPWLVGRYTTARRARIAELERREEAAVRRAVAEERSAVARDLHDVISHHVSAIGMHAGAARLGLPDGADTPVHRSLSAVETASRAAMQDLRRMLDLLHGEQAAVRQPGVGNLEELLEGTRAAGLPARLRTSGVPGELPGSVDVAVYRVAQEGLTNALRHGAGGPVDVELCYRPEEITLSVTNPITPGARPAAGEGTRRGLAGLRQRVAMFGGEFTSGPSDDGRSWRISATFPMEAG
>CP015163.1|AXB48843.1|5886335_5886965_+|DNA-binding-response-regulator
MFRSGMRAVLDTQPDLECVGEAADGRAAVAEVARLRPDVAVLDVRMPKLDGLAATEAILGTPGCVTKVLVLTTYDHDDYVYRALRAGASGFLLKNLPPEELVSAMRVVARGDALIDPSVTRRLVSRFTTSIEPPAGPAELDRLTSREREVLLLIADARSNAEIAEALHVGDETVKTHVSRILAKLGLRDRVHAVVYAYQHGLVRAAPRD
>CP015163.1|AXB48844.1|5887100_5888471_+|hypothetical-protein
MFWLLLGAGQANADGGPIGTDVHVAQTLGERELTVVIRRVTEVPGPLSVDVITHAGTAPGRLDLAASFAGTASARTQVELGATPGTYGATMTVDRAGPWELAVSDGTQVARIPFVVPAQVPAPWEKAAYGGFVAAGVLLLVALYAAVRARRSWHALLPATGVVAALAVAITAALLSSSIPPPARDVLDPTVDTVNDPYAPLPSTMDTNRPPLNLAVSGTPAGFTLRLTDSATGRPADDLVVHHNALVHLVAIGPSGRLWHLHPVRTAPGTYTARFGTTETGRFALSAEVARRGGGTQLLRSTLDTEGGPGAPEPVPGLGTRTIDGVPVTVHAGEVRANAATAMTAKFGDTGTLQPWLGMTGHLMVVGPLPDATPVGAATATAPTWAHVHSMTGLPVMSGRSAAGQPDETVAAYGPEVRFTYTFPAPGRYRLWFQGMRDYAVITAPVELDVPEGDRP
>CP015163.1|AXB45764.1|5888467_5888878_+|hypothetical-protein
MKKPVALGIAGAALLAVLAWLLWPAGSDGAASMEVAGQHHTVRLRVEAPKTGLNAFDLEVADALGHPAEGLEVTVEPVMAQMGHALEPVPATPRAPGRYHAADTLLPMSGQWEITVRLRDGTAGTEELVFPLLVGS
>CP015163.1|AXB45765.1|5888889_5890026_+|hypothetical-protein
MDLTASLSPPVATTRAAAGARAWLPASGLLAGTLITLVGLTWDVEWHDDVGPDTFFTLPHLFLYTGSAIAGLVSLVVVLSTTAAQRAGRPVDEAVGGRAVGVFGRTFAAPVGYLVAGTGGALFLLYGLWDLWWHSLYGFDAVIDSPPHIGLLLSVMVTMVGTVMVFAAARSHRWGVFGTLASVAVLLSFSSVTVLGLSDVDTAVNAVTIGMTFLSVMLILVARGFLGRPGGALGAAVLLGAWQAFSWWFSPWAAHAYAAAVGLPLRDNVDDLASMPALMPMCLVGAALLAELVLWATSRRGSAPRWAGALAGAVAGFVVAGAQPFQDAWLYETGVPAAGQLLATAGVGASFGLLGGYLGWRFGGMLRLLAPAREKETV
>CP015163.1|AXB45766.1|5890025_5890556_+|hypothetical-protein
MRKLLTLLATIGLLVASAPAASAYEPVNIVHTERVQAGPYGLTVGFSTWPLKAMQSLDFTFIPDGGIADKSGVFAMTNPETGRQGRENPLTRHPRKLDVWGLDIRALSSQGDWKFRFVIDGPAGRGEGELSRLPVLEQPGPPMALSWSISVLPLVGLIGFLAVAWRRTRDRLTERG

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Crispr_ID: CP015163_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP015163_10

6136792-6136893

Orphan

Consensus_repeat	Method
CCGTTGATTGCCGGGGCTTGGCTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP015163_10

>merge|CP015163|10|6136792-6136893|CRISPRCasFinder
CCGTTGATTGCCGGGGCTTGGCTTTTGTTCGGCTGGGCGCCGGTTGTGGTCGAAGCCCAGGCTCCGGTTCGGCTGAGGCCGTTGATTGCCGGGGCTTGGCTT

>CP015163|10|9|6136792-6136893|CRISPRCasFinder
CCGTTGATTGCCGGGGCTTGGCTT	TTGTTCGGCTGGGCGCCGGTTGTGGTCGAAGCCCAGGCTCCGGTTCGGCTGAGG
CCGTTGATTGCCGGGGCTTGGCTT

Protein	Signature genes	Signature genes Name	Protein_function
CP015163.1\|AXB45968.1\|6138717_6139326_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB45961.1\|6130119_6130959_-\|peptidase-S49	unknown	unknown	gnl\|CDD\|132934
CP015163.1\|AXB45958.1\|6127065_6127593_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB45970.1\|6140922_6141540_-\|peptide-methionine-(S)-S-oxide-reductase	unknown	unknown	gnl\|CDD\|234604
CP015163.1\|AXB45972.1\|6142248_6143136_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB45964.1\|6134437_6134878_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB45959.1\|6127595_6128426_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225818
CP015163.1\|AXB45962.1\|6132504_6133590_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|365903
CP015163.1\|AXB45965.1\|6137264_6137858_+\|chitin-binding-protein	unknown	unknown	gnl\|CDD\|237309
CP015163.1\|AXB45973.1\|6143132_6144266_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224748
CP015163.1\|AXB45974.1\|6144319_6145525_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223021
CP015163.1\|AXB45963.1\|6133582_6134434_-\|DNA-lyase	unknown	unknown	gnl\|CDD\|223344
CP015163.1\|AXB45957.1\|6125244_6127035_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
CP015163.1\|AXB45956.1\|6124798_6125140_-\|clumping-factor-B	unknown	unknown	gnl\|CDD\|377315
CP015163.1\|AXB45960.1\|6128511_6129825_-\|1,3-beta-glucanase	unknown	unknown	gnl\|CDD\|185691
CP015163.1\|AXB45955.1\|6123200_6124802_-\|cation-acetate-symporter	unknown	unknown	gnl\|CDD\|271374
CP015163.1\|AXB45971.1\|6141631_6142252_+\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB45966.1\|6137919_6138330_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379731
CP015163.1\|AXB45969.1\|6139547_6140918_+\|Zn-dependent-exopeptidase-M28	unknown	unknown	gnl\|CDD\|349911
CP015163.1\|AXB45967.1\|6138352_6138646_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226748

Protein	Function_ID	Function_description	E-value
CP015163.1\|AXB45961.1\|6130119_6130959_-\|peptidase-S49	gnl\|CDD\|132934	cd07023, S49_Sppa_N_C, Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad. Signal peptide peptidase A (SppA; Peptidase S49; Protease IV): SppA is found in all three domains of life and is involved in the cleavage of signal peptides after their removal from the precursor proteins by signal peptidases. This subfamily contains members with either a single domain (sometimes referred to as 36K type), such as sohB peptidase, protein C and archaeal signal peptide peptidase, or an amino-terminal domain in addition to the carboxyl-terminal protease domain that is conserved in all the S49 family members (sometimes referred to as 67K type), similar to E. coli and Arabidopsis thaliana SppA peptidases. Site-directed mutagenesis and sequence analysis have shown these SppAs to be serine proteases. The predicted active site serine for members in this family occurs in a transmembrane domain. Mutagenesis studies also suggest that the catalytic center comprises a Ser-Lys dyad and not the usual Ser-His-Asp catalytic triad found in the majority of serine proteases. Interestingly, the single membrane spanning E. coli SppA carries out catalysis using a Ser-Lys dyad with the serine located in the conserved carboxy-terminal protease domain and the lysine in the non-conserved amino-terminal domain.	7.14621e-77
CP015163.1\|AXB45970.1\|6140922_6141540_-\|peptide-methionine-(S)-S-oxide-reductase	gnl\|CDD\|234604	PRK00058, PRK00058, peptide-methionine (S)-S-oxide reductase MsrA.	3.3403e-138
CP015163.1\|AXB45969.1\|6139547_6140918_+\|Zn-dependent-exopeptidase-M28	gnl\|CDD\|349911	cd05661, M28_like_PA, M28 Zn-peptidase containing a PA domain insert. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins containing a protease-associated (PA) domain insert which may participate in substrate binding and/or promote conformational changes, influencing the stability and accessibility of the site to substrate.	2.0269e-65
CP015163.1\|AXB45959.1\|6127595_6128426_-\|DNA-binding-response-regulator	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	7.38114e-45
CP015163.1\|AXB45962.1\|6132504_6133590_+\|hypothetical-protein	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	2.29572e-48
CP015163.1\|AXB45965.1\|6137264_6137858_+\|chitin-binding-protein	gnl\|CDD\|237309	PRK13211, PRK13211, N-acetylglucosamine-binding protein GbpA.	2.40207e-74
CP015163.1\|AXB45973.1\|6143132_6144266_+\|hypothetical-protein	gnl\|CDD\|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	2.02528e-24
CP015163.1\|AXB45974.1\|6144319_6145525_+\|hypothetical-protein	gnl\|CDD\|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	4.09533e-06
CP015163.1\|AXB45963.1\|6133582_6134434_-\|DNA-lyase	gnl\|CDD\|223344	COG0266, Nei, Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair].	1.26495e-58
CP015163.1\|AXB45957.1\|6125244_6127035_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	5.44156e-64
CP015163.1\|AXB45956.1\|6124798_6125140_-\|clumping-factor-B	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	5.42959e-40
CP015163.1\|AXB45960.1\|6128511_6129825_-\|1,3-beta-glucanase	gnl\|CDD\|185691	cd02182, GH16_Strep_laminarinase_like, Streptomyces laminarinase-like, member of glycosyl hydrolase family 16. Proteins similar to Streptomyces sioyaensis beta-1,3-glucanase (laminarinase) present in Actinomycetales as well as Peziomycotina. Laminarinases belong to glycosyl hydrolase family 16 and hydrolyze the glycosidic bond of the 1,3-beta-linked glucan, a major component of fungal and plant cell walls and the structural and storage polysaccharides (laminarin) of marine macro-algae. Members of the GH16 family have a conserved jelly roll fold with an active site channel.	1.06267e-117
CP015163.1\|AXB45955.1\|6123200_6124802_-\|cation-acetate-symporter	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
CP015163.1\|AXB45966.1\|6137919_6138330_-\|hypothetical-protein	gnl\|CDD\|379731	pfam15585, Imm7, Immunity protein 7. A predicted immunity protein with an alpha+beta fold and a conserved GxaG motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a Tox-REase-3 domain.	4.14294e-49
CP015163.1\|AXB45967.1\|6138352_6138646_-\|hypothetical-protein	gnl\|CDD\|226748	COG4298, COG4298, Uncharacterized protein conserved in bacteria [Function unknown].	5.2125e-17

>CP015163.1|AXB45964.1|6134437_6134878_-|hypothetical-protein
MNRLVHGADGREWVLRSQLEWRPPATADDFEHDVAGSHTPGIAMLFVTVVLAVVLVVWMPEDVVVPSWVLLALLLIVIFFPLRWILRRPWTVVAETEGDPTGERPSERWVGTVRGMFTVRGEMSRIAKTIQKHSLPDFDGPLHPVE
>CP015163.1|AXB45963.1|6133582_6134434_-|DNA-lyase
MPELPEVEALAHHLREFAVGRVVSRVDVASMTVLKTVSPAWTELHGREVTGAGRFGKHLDLDCDGIHLVTHLARAGWLRWSDSLSPTPPKPGKGPLALRVHLSGPGFDLTEAGTKKGLAVWITRDPTEIPSIARLGPDALTVDRTKLAELFHGRTERLKTALTDQSLIAGIGNAYSDEILHTAKLSPYATTGKLSEEALDRLSGAISGVLTDAVERSVGQAAARLKGEKRSGLRVHARAGLPCPVCGDTVREISFADKAFQYCPTCQTGGKPLADRRLSRLLK
>CP015163.1|AXB45962.1|6132504_6133590_+|hypothetical-protein
MTNRSRKLLVGALVAGVLAAGVSPVTAAADPVHLELRANVTNGFPGALAYVREGERERRFGVGVANLATGERARPHQRFRTASITKSFTATVLLQLVAEGELGLDDPVERWLPGVLPDRGVTVRQLLDHTSRVYDPASTPEFFAPYLEHQDWGHVITPAEVIRRAVAHGPYPEPAYSNTNYLLAGLVVERVTGHDFGTELRNRILAPLRLHHTELPLTDPRLHGPHLHGYNLAREDHTTFSPSYDWTAGAIVSTVDDVAKFQRALLGGELLPPELTALGLGLEPFALPCEGGTQRVQGSQGSGPGYFSFAYTSEDRSRQIVVVLNSYDLGADVGGQGKQPYPGPREGPLPALSAALCQPAT
>CP015163.1|AXB45961.1|6130119_6130959_-|peptidase-S49
MSVTDKLTSRIPGLADRGDRKDVVSVVKLHGVITPQASPLTRGAINLSAVESALTRAFDHDRLKAVALLINSPGGAPTQSGLVAERIRQLADKKGVPVLAFAEDVAASGGYWLACAADEIFAHRTSLVGSIGVISGGFGFTGLLERFGVERRLHTAGENKSRLDPFSPEKPEDVEWLKKLHSQLHELFVTWVKERRGDRLNAGDELFTGDVWLGAKAVELGLIDGVGNLREVLAERYPDAEIAVAEPKKPLLAKLGIGAPAASLLEAVSAKATWARFGL
>CP015163.1|AXB45960.1|6128511_6129825_-|1,3-beta-glucanase
MITVPLTVPAGASVPPPPTGWTQVWADDFDGAAGTLPNGNNWRFSLGHGYPGGPANWGTGEIAAHTNNPANVSLDGSGNLRITPLRDGAGNWTSARIETNKQDFKAPENGVLRVESRLQMPNVTGDAALGYWPAFWMLGSPYRGNWWNWPGIGEYDIMENVNGLNSVWGVLHCGTAPGGPCNENNGIGASRPCPGTSCQSGFHTYGFEWDRSTSPNQLRWYVDGQQFHQVSQNQLDATTWHNMTSHAGYFIILNVAMGGAFPNGVAGFGTPTAATVPGHPMVVDYVAAWTRGGGGTGNPGGTDAYGTIQAENYQQQSGLSTQLTTDSGGGQNVATAANGDWARYNGVNFGSQTATQFKARVASGAAAGVSGLVEVRLDSLSNPPIGSFSVANTGGWQSWRTIPANISGVTGTHDVYLSFRSGQPSDFVNVNWFSFAP
>CP015163.1|AXB45959.1|6127595_6128426_-|DNA-binding-response-regulator
MLVTVSTHEDTSGLLVLAVDDEPHGLSELAHCLENNPHIRRIFTCTDATDALRLLASDDAEVRYRKDRGMAPVDAVFADLNMPGLSGMEMSRVFATLNPAPVLVFVTGHPEEAVNAFDLGAVDYVLKPCKQERLDKAIKRVLQSLQAAPAPAAPAGQEPVKTDDEVIAVELAGNTKLIPRANVRWVEAQGDYARLFTTDGSHLVRIPLAQLEERWEKAGFVRIHRSYLVALQLITELRMGQGGYQVVIGNEEKLLPVSRRHTRELKDRLVGSSRNG
>CP015163.1|AXB45958.1|6127065_6127593_-|hypothetical-protein
MTLGGDPYRQIGGVREPDPTLGKNLGRQARAEPVPASKTEPVPSGPLPAEHREPEHHARPRRQRVVLSGPKQSNALRARVELEEQTSWGELLIKDLVKAQLRTGVLLGLLVVVLLGALPLAFFLSPGFAGLRVIGVPVAWLLLGVAPFPLLLGVGLWYNRLAERHERAFVDMIEN
>CP015163.1|AXB45957.1|6125244_6127035_-|cation-acetate-symporter
MQLNPWALTGIVLVGMVTFYLGHRSSRFASSTHDFLVARRTVRSRRNAAAISGEYLSAASFLGVAGIVLKEGADALWFPIGFTAGYLALMLFVAAPLRRSGAYTLPDFLEARLGSMALRRFSTAFVVFIGILYMVPQLQGAGLGLTTILGTPAWVGAVVVTVVVTINVIAGGMRAITVVQAFQYWLKLFAIAAPTFVLCVVFIGGGGGPTAGSLGTPAPPVFPEETTVDVQTPVTLEVAVPTVLYADGVVDGVRSDGVVFWSPEVRPEVGEGTELRFPAGSPVPVVTGAVTDNATWLLPASDDITDLLSTYSLMFATFLGTMGLPHVLVRFYTNPDGKAARRTTVHVLLLLGLFYLFPALLGALSRLYVPQLLVTGQTDAAVLMLPSAVLGGVGGQILGAVTAAGAFAAFLSTASGLLVSVAGVLSTDVLPGRVRDFRLAAVLVAMAPLGIALALRQDDLSLSVGMTFALAASTFSPMLLLGIWWRKLTWTGAMAGMVVGGTLVLGALAINIISGYTGDWAPWFTVQPALFTVPAAFVATMVVSKATARRVPDDLNAVMLRLHAPDPLGFMRDRAVARFGQAEEKVRPGRGGRHRK
>CP015163.1|AXB45956.1|6124798_6125140_-|clumping-factor-B
MSTSEPVTEADWKRVQASPEFRQLRRRLRNFVFPMTALFLGWYLLYVVLADYAHGFMSTKLVGNINVGLVLGLLQFVSTFVITGLYVRHANRHLDPVADQIRHEVEGTEEGAK
>CP015163.1|AXB45955.1|6123200_6124802_-|cation-acetate-symporter
MNLAQGVQGSNPALNISIFGAFVVVTLVIVFRASRNTKTASDYYAAGRAFSGPQNGVAIAGDYLSAASFLGIAGAIAVYGYDGFLYSIGFLVAWLVALLLVAELLRNTGKFTMGDVLAFRMKQRPVRAAAATSTLAVSFFYLLAQMAGAGILVSLLLGISSTAGQAVVIAVVGVVMIIYVLVGGMKGTTWVQIIKAALLITGAFAMTVWVLARYGFNLSDLLGSAVERAGSDSVLNPGARYGVSDTSKIDFLSLGIALVLGTAGLPHVLMRFYTVPTAKDARKSVVWAIGLIGLFYLFTLVLGYGAGAIVGKDAINKAPGKENSAAPLLAQALGGPVLLGFIAAVAFATILAVVAGLTITASASFAHDVYANVIKKGKVSDSNAEVRVARITAVVIGAVAIVGGILAKDQNVAFLVALAFAVAASANLPTILYSLFWKRFNTSGALWSIYGGLGVTVVLIIFSPAVSGLPTSMIKGVDFHWFPLQNPGLVSIPVSFFLGWLGTVLSKEHNEDKYAEMEVRSLTGAGAEKAVPH
>CP015163.1|AXB45965.1|6137264_6137858_+|chitin-binding-protein
MAKKILGRIAAIAAGCVALPVVLAGVAQGHGYTTNAPSRAYLCKTGAVTNCGPIQWEPQSVEGPKGFPAAGPANGKICAGGLGQFAQLDDPRGGNWPAKQVSSGSNMTFSWTLTAAHATTSFRYFITKNGWNPAAPLTRDQLESQPFYSVPFGGQRPGWTVTHTGKLPAKSGRHLILAVWDIADTGNAFYQCADVQF
>CP015163.1|AXB45966.1|6137919_6138330_-|hypothetical-protein
MFEYHGWVTIQVSADGDEPDGLLDRAVDRVGRVVREFGNAQLVDLRYANDVPVLHLGGVLKRPSTVGASLLHLFIRVGELAPASYGLLHVHDDEDFAHGNEFRVYRMVRGQVTECADPFLSPVVPTVADADAYAEF
>CP015163.1|AXB45967.1|6138352_6138646_-|hypothetical-protein
MSKPVSSSSPTTGAFFAQAAISFGSAVLAVGLGVAFLPVDPWIRAFLGVAMLYAITSAFTLAKVVRDRQEDSYLLSRVDQARLDKLLAGHDPFKEPA
>CP015163.1|AXB45968.1|6138717_6139326_-|hypothetical-protein
MAYVTLPTFVSCSSSAGAKRATLVRRQRRMYDNPEPSGFDFYRRAAAAIRTGREADMDATAMDILVANATPRSAPHYRAVADGWLRYLGRRKPAVLNVGRARWRCGALEVGITPQFGLRSAAGDHAVHLYFKEEPLTRDAAHLALRLMELRMKDLLPSGGAPLVLDVRRSKAYTLGRRDRDRLDHWIRSEAAAFLALWEPVA
>CP015163.1|AXB45969.1|6139547_6140918_+|Zn-dependent-exopeptidase-M28
MAGIRRRDVMTGAVALAGAAAIGLNPATAAAAGRQRPGAAAKPDLAFGDYPVVARVRAQRALEHLKVLSDQIGPRIAGTPGELKARDHIASTLRKLRYQVTVQPFPIADKFLGRIRIGDENWQTGSSPQGAQNTTFSGEVVDVGSGAADSFPADVTGKIVFYAGITNDANAYQLAAQRGAAAVLIGRLSASADRKLSAFSPTLPAPVGIPVLGVAQVQAEKLRDRLRSGTTRLEVSSDHYTNLTSYNVLAERPATVPGGDQGVVMISAHYDSVPGSPGANDDGSGTVLCLELARVLRYLPTRKAVRFALWGSEEYGLIGSRYYVNNLPDAEARRIAGCFQNDMVATSYDPATVYWLLSVDGADNAVTQAVGAAAQRLGYDPRVQGPVARGSSDHVPFFERGIASGNFSWRGETGPAALEPTYHTPEDTIADNVSLERLQVSLELIGAAAYDLLRRE
>CP015163.1|AXB45970.1|6140922_6141540_-|peptide-methionine-(S)-S-oxide-reductase
MSLPGRAEPLVTPDFHAVFPDRRIKPPFPEGLRAAVFGMGCFWGAERLFWQTSGVYSTAVGYAGGETPNPTYEEVCSGLTGHAEVVLVVFDPARVSYGQLLKVFWEGHDPTQGMRQGNDVGTQYRSAAYFADDSQRAEIESSRASFQPALTAAGHGAITTEVAPLGAFYYAEDYHQQYLHKVPNGYCGLGGTGVSCPIGLGVADS
>CP015163.1|AXB45971.1|6141631_6142252_+|hypothetical-protein
MVVTAALLAVLAIPPTAAWLAWGSGANPDREVQPTALADPEPRRPGPPPLPLVTPPGDLLIDRASRISALVSYQLFSQEELDELVATGVAAAHLRMTRENGVNLLLSRFTSRDDAEPEKTKEALDGIYAAGGHQRVDPAPAGVTVRRFSEAPDAPTVSYHAHYVRGRDVLRIDASGEAGVLGEKIDQAFGSLLGEQTEAFPAGEPR
>CP015163.1|AXB45972.1|6142248_6143136_+|hypothetical-protein
MRTPVVLLSASAAVLTAYGYLFGQWADRHDQRFAVLDVTREWIARPLGLGEDFGPLGLMLLLVAAGYAAAAGRAPGELYPLAVLVVVAHLLPPTAGLVPLGWVPVLALAGFLLARGTALLPARYRWTGQLAQLVLALNAVALADFVPDLSAAAAFFPLFVAGQLLHANRAGLLPAWGCGLLIAAALAVVSIADRVVPELDGWWYPLAATYAMLLGAVAFLLAGPTADRIAANPVPRWLAERVWWLVPLYAAVGHPLAGLLPHPAGILVAAVGVGLLAEAGHRGSRLLFQRTKEAV
>CP015163.1|AXB45973.1|6143132_6144266_+|hypothetical-protein
MTQTAERPAPAGAPARGSHYMHGLDVLRVICSVAVLYNHVAGWAKMRGSDDFWLADLIEGGVVESLHLNELLGFVGVGTFLVISGVVVTHVSTREAPGQFLARRAVRLFPALWVAILLAWVLALTGVLGVNHPPEFGDLLLNLGLLNYSVADASTLLAVTWTLTVQVVFYLLAAATIPLLRRWPWLPPAIGAALVSVLISVTNNPTEGGPASLRIIASFLPVLFLGQLVMLVRGKRLAPLPAIALGLVHLWLAARAAATWSGTPDGPAYVRTLVLILLLLLLCTRANGRIARSRVIKVLADRTYAVYLLHFAVVLGTLNLLADPLGFWPALGIGLIVLAITTELLHRFVERPLARGFRRWEARRAARKTEFTRSSDR
>CP015163.1|AXB45974.1|6144319_6145525_+|hypothetical-protein
MGWQEELRLLDAKLADGSLTPAQHRKMRDELLAAASGGGSTSPVAAPRRETDPAMQETAVLPRIPVAGQPMPAGQVKPPPNAVGEARPAPKVVESRPTLPLGNPDHKQPPNAAALLAGDRPTTAPSPADQRATESMAVPPRGLSRGRSVLSPVAAHQPTRPYATEAQRSWTDPPPPPDYAQDDHSPRRTGSTWLFLALGVLLAGGLLAGGVWLLSKDEPAASTAAPPPSAPAQSSEQLPPPPANLPLEQRLPELPGTQNANNSTMPVDRGTELKLYAPETANMFKQNGASEVVYRSSSDGTDGYLVMVVPAGSPEGAKNIADELRKAAADTGFTQLNLGMPPGKSALAGSNTVGRMNATWYTSDNLAVAVWVSQGFDKQQFALGERLKGTLAKVEAALPPD

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Crispr_ID: CP015163_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP015163_11

6531533-6531763

Orphan

Consensus_repeat	Method
GCCGGGGCGGGCGCCTTGGTCCGGCGG	CRISPRCasFinder

4 spacers

The CRISPR arrays of CP015163_11

>merge|CP015163|11|6531533-6531763|CRISPRCasFinder
GCCGGGGCGGGCGCCTTGGTCCGGCGGGCCTGGGCGGCCGCTTTGGAGCGGCAGGTCGCCGGGGCGGGCACCTTGGTCCGGCGGTCCTGGGCGGGCCGCTGGGTCTGGGATGCCGGGGCGGCCGGGCAGGTCTGGGCGGCCTGCCGAGTCCGGGGGGCCGGGGCGTGCGCCTGGGGGCGGTGGGGTGTGGCGGCCGCCGGGGTCGCGGGGGCGGTCGGCTGGGTCCGCGGG

>CP015163|11|10|6531533-6531763|CRISPRCasFinder
GCCGGGGCGGGCGCCTTGGTCCGGCGG	GCCTGGGCGGCCGCTTTGGAGCGGCAGGTC
GCCGGGGCGGGCACCTTGGTCCGGCGG	TCCTGGGCGGGCCGCTGGGTCTGGGAT
GCCGGGGCGGCCGGGCAGGTCTGGGCG	GCCTGCCGAGTCCGGGGG
GCCGGGGCGTGCGCCTGGGGGCGGTGG	GGTGTGGCGGCCGCCGGGGTC
GCGGGGGCGGTCGGCTGGGTCCGCGGG

Protein	Signature genes	Signature genes Name	Protein_function
CP015163.1\|AXB46263.1\|6534902_6537065_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB46257.1\|6526390_6527182_-\|hypothetical-protein	unknown	unknown	unknown
CP015163.1\|AXB46261.1\|6532377_6533223_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
CP015163.1\|AXB46266.1\|6539244_6540552_+\|histidine-kinase	unknown	unknown	gnl\|CDD\|226951
CP015163.1\|AXB46259.1\|6527872_6529462_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270875
CP015163.1\|AXB46255.1\|6524907_6525231_-\|thiol-reductase-thioredoxin	unknown	unknown	gnl\|CDD\|200072
CP015163.1\|AXB46254.1\|6523506_6524655_-\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|119407
CP015163.1\|AXB46258.1\|6527178_6527829_-\|RNA-polymerase-sigma-factor-SigM	unknown	unknown	gnl\|CDD\|236604
CP015163.1\|AXB48920.1\|6533866_6534793_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270408
CP015163.1\|AXB46251.1\|6520246_6521191_-\|D-alanine--D-alanine-ligase	unknown	unknown	gnl\|CDD\|234948
CP015163.1\|AXB46262.1\|6533219_6533864_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
CP015163.1\|AXB46252.1\|6521219_6522542_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224089
CP015163.1\|AXB46267.1\|6541412_6543329_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379424
CP015163.1\|AXB46256.1\|6525263_6526256_-\|thioredoxin-disulfide-reductase	unknown	unknown	gnl\|CDD\|273540
CP015163.1\|AXB46265.1\|6537693_6539157_+\|CCA-tRNA-nucleotidyltransferase	unknown	unknown	gnl\|CDD\|131739
CP015163.1\|AXB48922.1\|6543413_6544499_-\|ADP-ribosylglycohydrolase	unknown	unknown	gnl\|CDD\|377122
CP015163.1\|AXB46253.1\|6522754_6523375_+\|GCN5-family-acetyltransferase	unknown	unknown	gnl\|CDD\|173926
CP015163.1\|AXB46260.1\|6529537_6531349_-\|lipid-II-flippase-MurJ	unknown	unknown	gnl\|CDD\|240528
CP015163.1\|AXB48921.1\|6540548_6541409_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369778
CP015163.1\|AXB46264.1\|6537061_6537592_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|239645

Protein	Function_ID	Function_description	E-value
CP015163.1\|AXB46265.1\|6537693_6539157_+\|CCA-tRNA-nucleotidyltransferase	gnl\|CDD\|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	0
CP015163.1\|AXB46261.1\|6532377_6533223_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.57786e-59
CP015163.1\|AXB46266.1\|6539244_6540552_+\|histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.28016e-24
CP015163.1\|AXB46259.1\|6527872_6529462_-\|hypothetical-protein	gnl\|CDD\|270875	cd13973, PK_MviN-like, Pseudokinase domain of the peptidoglycan biosynthetic protein MviN. The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This family is composed of the mycobacterial protein MviN and similar proteins. MviN is an integral membrane protein that is essential for growth and is required for cell wall integrity and peptidogylcan (PG) biosynthesis. It comprises of 14 predicted transmembrane (TM) helices at the N-terminus, followed by an intracellular pseudokinase domain linked through a single TM helix to a carbohydrate binding extracellular domain. Phosphorylation of the MviN pseudokinase domain by the PG-sensitive serine/threonine protein kinase PknB recruits a forkhead associated (FHA) domain protein FhaA, which modulates local PG synthesis at cell poles and the septum. The MviN pseudokinase forms a canonical receptor kinase dimer.	3.94759e-66
CP015163.1\|AXB46255.1\|6524907_6525231_-\|thiol-reductase-thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	5.09294e-50
CP015163.1\|AXB46254.1\|6523506_6524655_-\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|119407	cd02696, MurNAc-LAA, N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino acids in certain cell wall glycopeptides. These proteins are Zn-dependent peptidases with highly conserved residues involved in cation co-ordination. MurNAc-LAA in this family is one of several peptidoglycan hydrolases (PGHs) found in bacterial and bacteriophage or prophage genomes that are involved in the degradation of the peptidoglycan. In Escherichia coli, there are five MurNAc-LAAs present: AmiA, AmiB, AmiC and AmiD that are periplasmic, and AmpD that is cytoplasmic. Three of these (AmiA, AmiB and AmiC) belong to this family, the other two (AmiD and AmpD) do not. E. coli AmiA, AmiB and AmiC play an important role in cleaving the septum to release daughter cells after cell division. In general, bacterial MurNAc-LAAs are members of the bacterial autolytic system and carry a signal peptide in their N-termini that allows their transport across the cytoplasmic membrane. However, the bacteriophage MurNAc-LAAs are endolysins since these phage-encoded enzymes break down bacterial peptidoglycan at the terminal stage of the phage reproduction cycle. As opposed to autolysins, almost all endolysins have no signal peptides and their translocation through the cytoplasmic membrane is thought to proceed with the help of phage-encoded holin proteins. The amidase catalytic module is fused to another functional module (cell wall binding module or CWBM) either at the N- or C-terminus, which is responsible for high affinity binding of the protein to the cell wall.	2.18743e-53
CP015163.1\|AXB46258.1\|6527178_6527829_-\|RNA-polymerase-sigma-factor-SigM	gnl\|CDD\|236604	PRK09643, PRK09643, RNA polymerase sigma factor SigM; Reviewed.	4.42721e-84
CP015163.1\|AXB48920.1\|6533866_6534793_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270408	cd13690, PBP2_GluB, Substrate binding domain of ABC glutamate transporter; the type 2 periplasmic binding protein fold. This group includes periplasmic glutamate-binding domain GluB from Corynebacterium efficiens and its related proteins. The GluB domain belongs to the type 2 periplasmic binding protein fold superfamily (PBP2), whose many members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.92349e-82
CP015163.1\|AXB46251.1\|6520246_6521191_-\|D-alanine--D-alanine-ligase	gnl\|CDD\|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	1.19822e-92
CP015163.1\|AXB46262.1\|6533219_6533864_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.99038e-57
CP015163.1\|AXB46252.1\|6521219_6522542_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	7.81412e-124
CP015163.1\|AXB46256.1\|6525263_6526256_-\|thioredoxin-disulfide-reductase	gnl\|CDD\|273540	TIGR01292, Thioredoxin_reductase, thioredoxin-disulfide reductase. This model describes thioredoxin-disulfide reductase, a member of the pyridine nucleotide-disulphide oxidoreductases (pfam00070). [Energy metabolism, Electron transport].	1.24561e-150
CP015163.1\|AXB46267.1\|6541412_6543329_-\|hypothetical-protein	gnl\|CDD\|379424	pfam14021, TNT, Tuberculosis necrotizing toxin. This is the C-terminal domain secreted by Mycobacterium tuberculosis (Mtb). It induces necrosis of infected cells to evade immune responses. Mtb utilizes the protein CpnT to kill human macrophages by secreting its C-terminal domain (CTD), named tuberculosis necrotizing toxin (TNT) that induces necrosis. It acts as a NAD+ glycohydrolase which hydrolyzes the essential cellular coenzyme NAD+ in the cytosol of infected macrophages resulting in necrotic cell death. CpnT transports its toxic CTD from the cell surface of M. tuberculosis by proteolytic cleavage, where the toxin is cleaved to induce host cell death. Structural analysis determined that the TNT core contains only six beta-strands as opposed to seven found in all known NAD+-utilizing toxins, and is significantly smaller, with only two short alpha-helices and two 3/10 helices. Furthermore, the putative NAD+ binding pocket identified Q822, Y765 and R757 as residues possibly involved in NAD+-binding and hydrolysis based on similar positions of catalytic amino acids of ADP-ribosylating toxins. While glutamine 822 residue was detected to be highly conserved among TNT homologs.	4.63882e-20
CP015163.1\|AXB48922.1\|6543413_6544499_-\|ADP-ribosylglycohydrolase	gnl\|CDD\|377122	pfam03747, ADP_ribosyl_GH, ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.	1.47519e-51
CP015163.1\|AXB46253.1\|6522754_6523375_+\|GCN5-family-acetyltransferase	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	2.47782e-05
CP015163.1\|AXB46260.1\|6529537_6531349_-\|lipid-II-flippase-MurJ	gnl\|CDD\|240528	cd13123, MATE_MurJ_like, MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.43696e-108
CP015163.1\|AXB48921.1\|6540548_6541409_+\|hypothetical-protein	gnl\|CDD\|369778	pfam08242, Methyltransf_12, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	1.82612e-08
CP015163.1\|AXB46264.1\|6537061_6537592_-\|NUDIX-hydrolase	gnl\|CDD\|239645	cd03673, Ap6A_hydrolase, Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most preferred substrate, hydrolyzes to produce two ATP molecules, which is a novel hydrolysis mode for Ap6A. These results indicate that Ap6A hydrolase is a diadenosine polyphosphate hydrolase. It requires the presence of a divalent cation, such as Mn2+, Mg2+, Zn2+, and Co2+, for activity. Members of the Nudix superfamily are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site.	8.10732e-44

>CP015163.1|AXB46260.1|6529537_6531349_-|lipid-II-flippase-MurJ
MRPWNRERQDGPPPPRPRVEYTQLIPVDRGLPPGARWPTADPDMHRPYDEYATRFIPRISDGVAPTEAQPSGGASGPSLAKSSGRMAIATLTSRITGFAWKVMLGWVAGLGIIYDSFTVANTLPLIINELLLGGVLTSVVVPLLVRSQDDEDGGEAYTQRLLTMATTVLLIGTVLSVAFAPQVTGLLMSDGEDANPALATWFAYLLLPGLLFYGLFAVLSAILNAKQIFGPAQWAPVINNLVIFVTIGLYAILPGDPTLVPSKMSEPKVLVLGLGVLTAMTVQALFLLPALKRSGFKFKWRWGLDSRLKEFSGLAMWIFAYVAISQVGMIINTNVLTSGQAGGVSIYSNAWLLFQLPYGVIGVSLLTAIMPRMSRAAADGETKKLVADLSYASRISTVMLVPISAVMTVAGTSIGVALFAMGKGELADAERLGQALAVSAFGLLPYALVMLQMRVFYAMKDSRTPTLIMVVMTGVKIPLLYLASALLAPQHIVLGVMMVNSLVFVIGAIMGQVWLWVRLGNLRSKRVLGVILFTVVASAAGVGAALVVGMIVPDALGATLQAWVKLVLQGVVGIGVSFGVLMALKVEELKPATSRITRLIKRG
>CP015163.1|AXB46259.1|6527872_6529462_-|hypothetical-protein
MDTSRKEGGAGKVGARARSGPLAPGAVVGDGRYRLLAQFGIDERADAHLWRARDGQLRRDVALTLLVGDPADADAARLARRTLERAAHAAKFSHDGVARVLDVLNLGNGITSSEGLLGIVVAEWTKGSDLVDLVADKPVEPGAAARMVGALAQAVEQAHQSGLVLGLDHPQRLRLTPDGALRLAFPGPLPDATLRDDVKAIGGVLYLLLTGRWALPGGPPAIPTAPHAPNGRIVPPRSLQPRVPQTLSSLAVRTIEDGGHGGIRTSSAILAVLDQAAEEEERTQLIQQVGTAPEEEADADGAIWTTKKPVRDSARRRKLALGVTVLVVTAVGILAWLGMLAISFFQESPDSGGPTVNVAEPTPTAAPDPGGNPAPPPADQPSGGPPVKPQTVNVYNPSGEGDAPARAKNVLDGKRETFWRTDEYRQQFPDLKPGVGLLNSFEQSVRLSAVKIAADSPGTTVEIRTADKKNPKFSETRLVGSGELTGPDNEIKLSEPAEGRYVIVWITKLGTDGDKHVTQINDLEFIAAA
>CP015163.1|AXB46258.1|6527178_6527829_-|RNA-polymerase-sigma-factor-SigM
MTAATPTDAALIAAHAAGDPHAFSELVRRHRDRMWAVALRTLRDPEEAADALQDAFISAFRAAGNFRAESQVTTWLHRIVVNACLDRVRRRQARPTVPLPETSHNEPATPRDSMSERETRLVIKEALDQLPEDQRAPIVLVDVEGYSVAETAEMLGIAQGTVKSRCARGRAKLAKVLGHLRNPDAEPGVPTNESKHDRTERRVSRPLGTQGQREGR
>CP015163.1|AXB46257.1|6526390_6527182_-|hypothetical-protein
MTDESRGVGGAVGPPWSVDVLADLHAGVLDEREAAELWPLVRADAEASAIIEALESTTADLAALGDADVEPMPAEFAARLDAALAEEMARSAGNAGPAEPTAPPVAPVVGIDVARRRRRARIAGWSAGVVGIAAAAIAAIAIAVPGGSGNDGAGQPPVAQPPPGAGSNEPPLALQQDNIPIGEILGSTGKMDYGPLGTRDRVDQCLAQNGFDPAVKPAGIRGATIDGQPATLVILTPGTIGQFQLVGLSPDCAKVMDKTVGGK
>CP015163.1|AXB46256.1|6525263_6526256_-|thioredoxin-disulfide-reductase
MAAEDVRNLIIVGSGPAGYTAAVYAARAQLDPLVFEGSQFGGALMTTTEVENYPGFRDGIQGPALMEEMREQAKHFGADLRAEDVEELDLTGEIKYVTVNGKRYAARAVVLAMGAAARYLHVPGEQELLGRGVSSCATCDGFFFRDHDIAVVGGGDSAMEEATFLTKFAKSVTIVHRREEFRASKIMLERARANDKIKWALNKAITGVIGEDKVSGLKLEDTRTGETSTLDVTGFFVAIGHDPRSELVRGQVDLDDNGYVVTKGRSSYTNLDGVFAAGDLVDHTYRQAITAAGSGCAAAIDAERWLAEHAVTEQAAEAPELVGGGYGAGN
>CP015163.1|AXB46255.1|6524907_6525231_-|thiol-reductase-thioredoxin
MTDTVKVTDSSFTDDVLTSDKPVLVDFWATWCGPCRMVAPVLEEIASENKDKLTIAKLDIDENPNTARDYQVMSIPTLILFQGGKPVKQIVGAKPKAALLSDLSDVL
>CP015163.1|AXB46254.1|6523506_6524655_-|N-acetylmuramoyl-L-alanine-amidase
MRVLRRGDAGPDVAEIRSMLAALDLLPPANGSPQEHGAFDMAVEQAVRAFQQRRGLITDGIVGPATYRALRGSSYHLGSRPLAYLISAPVHGDDVFALQERLTELGFDAGRPDGVFGPQTEQALRTFQRDYGLVVDGICGGGTVRALRQLSPRARGGRPVFLREQEQVRRSGPRLRGKRIVIDPGHGGQDGGVEVGGLREADIAWDLARRLEGRMKATGMEALISRGPDHSPAEADRAAFANDAGADLFLSLHSDQNQSPYAQGVASFHYGTGNGTSSTVGELLAGFIQRELAARTGLLDCRAHPKTWEILRLTRCPAVRVEIGYLTNPDDRRRLSDPAFRDVVAEGILIAVKRLYLLGEGDQPTGTFTFADVLAYELAKAD
>CP015163.1|AXB46253.1|6522754_6523375_+|GCN5-family-acetyltransferase
MGVTLDNLDQVPLHCRRCVFWEVAPHLKAQAEEFGETEVEKEAWVSSVLLEWGSCGRIVYSDTLPIGFVLYAPPNAVPRANAFPTSPPAPDAVLLTAFHVAPEFRGGGLGRMLVQSVAKDLTRRGVKAIEAFGATEPASDGEHACVLPAEFLQSVGFKTVRPHPKFPRLRLELRSAISWKEDVEAALERLLGQVTITTAEPSVARS
>CP015163.1|AXB46252.1|6521219_6522542_-|GntR-family-transcriptional-regulator
MSEKRPARQPHSGHHNLDPHLPRYAARTAGMTASEIRALFAVASRPEVVSLAGGMPNLAALPLESLSSQMAELIAKDGLTALQYGSAHGVPALREQICEVMALEEISAHPDDVVVTVGSQMGLDMVTRLFCDPGDVVIAEGPSYVGALGSFAAYQAEVVHVAMDDQGLVPEGLREALAQCRTHGKRVKFLYTIPNFHNPAGVTLAVERRAEILEICREHDVLVVEDNPYGLLGFDGQTYPALRSMDPDNVVYLGSFSKTFASGLRVGWVLAPHAVREKLVLAAESATLCPPTLNQLVVSRYLATHDWKGQIKTFGENYRERRDAILSALEQHMPPGCSWTHPDGGFYVWVTVPEGVDTKAMLPRAVTARVAYASGTGFYADGFGSRQMRLSYCYPTPERIREGVRRLAAVLESEMDLMRTFGSVNPRAVSGPENPSPDTA
>CP015163.1|AXB46251.1|6520246_6521191_-|D-alanine--D-alanine-ligase
MAERTVAVLAGGLSHERDVSLRSGRRLSAALRAEGLTVEEWDTDAGLLERLRTQRPDAAVVALHGGQGENGSVQTVLEMLDVPFVGTSSQGCRRAWDKPTAKALLAKADFATPDWVVLPHSTFRELGAQAVLDAMVDRLGLPLILKPDQGGSALGTQVVRDAAELPAAMVGCFAYGDTVLAERFVDGVEVAVAVVETEAGPTALPAVEIVPESGVYDYTARYTAGLTDFFAPARLSEQSAKAVGELAVAAHQLLGLRDISRTDAVVDADGTVHFLEVNLSPGLTETSTVPMAIEAGGGSLGAVFAELIDRAIKR
>CP015163.1|AXB46261.1|6532377_6533223_-|amino-acid-ABC-transporter-permease
MNALFDEPGPRARRRIRIATVVSALAGAVLFALAVRQFAVNGELDWKKWAPYTQWPNWRYLLTALGQTLLAAALSAGIGGLAGLLLAVARVSRNVVVSGLARAYLETVRVIPAVLLIYMVLFVLPSLGLDLPLLWKLVVPLAVSSSAQFGEIFRAGILSLDRGQGEAAAALGLRTGQSMRLVILPQAVRRVVPSLVSQTGGVLKDTSLGFFVSYAELLFSGKVLIGYYQNQLLIQTYLVIGAIYFTANYALSRFARWLERRRDVPVIRTGHPRAITLGSVE
>CP015163.1|AXB46262.1|6533219_6533864_-|amino-acid-ABC-transporter-permease
MDVLLDNFGTFAEGVLTTIELTTLSFAGALAIALVIVTFRVSPVRPLRFFGTAYVELFQNVPLLLWILFFVFGLPKLGIQFELFTTAVLAVSMYSAAYYAEALRTGINTVSTGQAEAARALGLGFGQSLRWVILPQALRSVVQPLGNLTVMLLMNTALAAGAGLVELSTAANRVNLVEAEPILIFSGAAVVYALLALVITGVTRLLERRLVIHR
>CP015163.1|AXB48920.1|6533866_6534793_-|ABC-transporter-substrate-binding-protein
MAALKTRRMLVLTCAIATLSTAAACSGEPGALPGSPGASGQGIIDRAPVASAEAIAASPTATAIKQRGQLLIGGSLDAPLLSQQNPATGETEGFDATLGKLLAKYIIGTPDAKIVNSSSETREALLQNSTVDVVFQTYTITPQRAEKVAFAGPYLMSGQAIATMKDKSAIRKPSDLNGKKVIAGANTPGVEAIKAQAPNAEVITFATDPECVQALEQNRGEAYVQDLTLLAASARLNDKIQIVGEPFTSDPYGIGLKHGDDAFKKFVNDWLVRLQQAGIWQQVWKDSLGTVVTGEAPAPPAIGSVPGS
>CP015163.1|AXB46263.1|6534902_6537065_-|hypothetical-protein
MKRLASATLTAFLLVLQAFIGVPAGGAPAQPGPDAPSRLRLDIDEMNPRLLVSTSATLTVAGKVTNTGDRRITDVQVRLQFGERQTTSRQLGEALAEAPPTDASITKYVDVARVIEPGQTVPLLITVPLGGDAKPLVSRPGVYPLLVNVNGTPEFGGQARLAAFSMLLPVLGVPGQSAPPRPERPTELSVLWPIADTRPRVVAAPFGGTLVLSDDQLATDLAPGGRLDALVTAPKNIKGEPRLFDSMCFAIDPDLLETVEKMAGGYLVRTPDGGQAPGRGHDTAARWLTSLRQLLQDSCTIQLPYADADLPALAKVTDGDPRLAKTAVDNTSLFERLLGVKPLPGVLWPNGGLDSATLAALGDARVTTVLAESDQLVSNRPLTAPATIEGTNLRGVALDPLLSRSMAATRPVEGAAANLTPADDPDLAAQNALAVLAFQTGAQSDTAGAPLLLAPPRRWTAPVDELTLLLRTIGDYSGLGMVTSKPLLEELAKPVKGTAKMEYGAKDAPAELPQPVISSLSQTERETADFGSSLTGDATTQVEPEDLIKPIRSGLMRASSTAWRADSAGALASAEDARGQLDALRGQVTVETPKQQISLASDTSPLPVTLKNSLPVGVTVRINLTNFTGLRPEQIPDRPLPARGSVPHLIQAEALRTGHFSVDVSLSTPGGTPLGSPARMELNSTQFGLITLIVTIVAGAALLLLSGRRIYRRIRGKDRA
>CP015163.1|AXB46264.1|6537061_6537592_-|NUDIX-hydrolase
MPGSAGRSGGAKPGRRSRRRRGRRLTTVDETSAGGLVVDAERENAVLIGRLDRRGKLLWSLPKGHIEDGETTEQTAVREVKEETGISAHVLQPLGTIDYWFVAERRRVHKTVHHFLLEAAGGELSDEDVEVTEVAWVPVAELEAKLAYADERTLVRKARELFAEQASRSSAEGVPE
>CP015163.1|AXB46265.1|6537693_6539157_+|CCA-tRNA-nucleotidyltransferase
MNELVVQRNAVIELMRISPVADQLADRFAAAGHRLYLVGGSVRDALLGRLSPDLDFTTDARPDQVLAVVAGWADAVWDVGIAFGTVGVTKGGSQLEITTFRADSYDQVSRNPEVTFGDTIEGDLLRRDFTCNAMAIELPSKSFVDPHGGLDAVRLKVLDTPATPQESFTDDPLRMLRAARFVSQLGFEPAPRVVEAMTSMAGEIRRITAERVQAELSKLITGAHPRLGLELLVDTGLADHVLPEVPGMRLAIDEHHQHKDVYQHSLTVLDQAIALERKDDPDAEPDLVLRLAALLHDIGKPATRKFEEGGGVSFHHHEVVGAKMARKRLRELKYSKEIVEQVSQLVFLHLRFHGYGKGEWTDSAVRRYVTDAGPLLPRLHKLVRADCTTRNKRKAAALQRTYDDLEARIARIAEAEDLARVRPDLDGNEIMKLLGLPPGPLVGKAWKFLKELRLDRGPLAHDEAVAELRRWAAEQGITPPDEPERTD
>CP015163.1|AXB46266.1|6539244_6540552_+|histidine-kinase
MRRQGPPQQASFLLTLLRRGAPAIATATSELSDGVADPTPVRALRRISAMAAPVDQRASDGLLLRAGRYVAFVPMVYRLVAVPGALAAYLGVHGGTGAVPVVAVAVVSVLLNLYGMRWMLRSAPFRSDRAAVLLTVDAVFTALANLAVAALVPTEVYAEAIGVPGKHLLGTVALFTLALGLPYGIGLLLGSIPLHLLMGWANTGTVQVESAFAGLGTMAGVLLTASGALVLIGLGTRLALAYGIRNGRQAERARQHRLMHDTVLQTLESMALPGEGTAEEQLDEVRRLARAEAVEVRKYIEAAENEGARPLGEKLASLAAEMARDGLRAQVVIAELDEDTLSEVRQIAIRDAVREAMRNTMKHSGTDKVLVRVEERDGGIAVIIRDHGTGFSAESRPPGFGISESITARLAEVGGRATVESTPGNGTRVTLWVPC
>CP015163.1|AXB48921.1|6540548_6541409_+|hypothetical-protein
MTESTQELLVACLTALRDEDRPKAAVLADQAAKSGARLGAELSRHLGSASDGHVYDQPAAFTAFIRGGGNVNLYAQLARRLAGLYNERRPASLLDLGCGDGLALVPALEKAAHRPSRIDLVEPSAALLEVAAQRVDGANARQTTAQEFLAETELSWDLVQSTFALQSLEPGDRQEVFHTLRERTGELVLAEFDVPDVTEHSPEHLASLVERYERGVAEYGQDGDLVAQGFLMPMLLGLVAPGGVRNNWEQPADDWRGQLTAAGFAEVEVTPLADYWWSPAVLIRAR
>CP015163.1|AXB46267.1|6541412_6543329_-|hypothetical-protein
MRYRIDAAERPDSLYAVWNGGVFRAQRSTADGTVLLVAQPGEEAPEDFDTEWNGRPAKVVPEAEAATTFSVQTHCLFADEIYRVAPQDGEALTLRWTGQDEARARELGLTEFTTTAAPEEVEALWQERHDFVAANGPRPERGTGDPNALLRAIGRTMLKVLPDGWERVGAQLRQVGGYAELEVRAIAGDLVVSLSPPAELGQLFTLLRSAMYQPSTGTWFEGTFTLDSSSNFDFDFDVDAEPHWRLAPGEGGRPTARAYEAELELYPRDRKHVPDWLAAKAGLPLDVVFRQAKVVDSHIEGEKPVVNRPPLPPDEVRRVLDYLYRSPVAFGRPVPLPDLFSPHGRPDVPDAFHTDGTWIWPAAVPHYLRKYGVPPEPELVDHIRANLHRPPYVPDKLRHTAEAEVLGKPYPPQSEEDLPKPDEHARGERDGDGLPKLRAAGVLDVLHRRLAELGVPASRYRIGEPADGAWCLRRVGGHWEVARFEGGEPVDPVPFDHVQDAARHLVGTMVLYPALAREPEEAESGHPTDWPILPLRGEPPLNFFRAKRMVVLPAGTVVQRFGNEAGNLVHPEHVRFPETSLAFEREREQHTYVVHRPLRVLTGITVPWGALPGGAVAYLLPRPLGQHVETKAMEKVSA
>CP015163.1|AXB48922.1|6543413_6544499_-|ADP-ribosylglycohydrolase
MSRDDRFLGSILAGAVGDALGAADEFEPIHIIRELRGPAGITDLVPAFGGLGKITDDTQMTLFTLEGLIRGHAHLRRGGQTGLEHFVQSAYQRWLHTQDYSWEDCRGPQNTSLEPDGWLITHRELFSRRAPGKTCLTALMSYGNNGQMGSFTHRLNTSKGCGGVMRTAPAALWPGDPGTVFGVGAMAAALSHSHPSGYLSAGALSVIVRHLIDGGTLPDAVDEAFRQLARWQHHEETTAALRVGVRLAEQGPPTPEKIATIDGGGWIGESALAIAVYVALATDNLDEALLAAVNHSGDSDSTGAICGNIAGAMYGPGALRPSWLEHLELRNTIEELAADALAEFGPEPPAHSLWERKYPNS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP015163_2	2.2\|2307365\|25\|CP015163\|PILER-CR	2307365-2307389	25	NZ_LN832562	Paracoccus aminovorans isolate JCM7685 plasmid IV, complete sequence	200033-200057	3	0.88
CP015163_2	2.2\|2307365\|25\|CP015163\|PILER-CR	2307365-2307389	25	NZ_CP008890	Dermacoccus nishinomiyaensis strain M25 plasmid unnamed, complete sequence	69121-69145	3	0.88
CP015163_2	2.2\|2307365\|25\|CP015163\|PILER-CR	2307365-2307389	25	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	38366-38390	4	0.84
CP015163_2	2.2\|2307365\|25\|CP015163\|PILER-CR	2307365-2307389	25	NC_014213	Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence	231109-231133	4	0.84
CP015163_2	2.2\|2307365\|25\|CP015163\|PILER-CR	2307365-2307389	25	NZ_CP032348	Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence	613653-613677	4	0.84
CP015163_2	2.2\|2307365\|25\|CP015163\|PILER-CR	2307365-2307389	25	NZ_CP012748	Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence	1243281-1243305	5	0.8
CP015163_11	11.2\|6531617\|27\|CP015163\|CRISPRCasFinder	6531617-6531643	27	NZ_CP049361	Deinococcus wulumuqiensis R12 plasmid unnamed4, complete sequence	5664-5690	5	0.815
CP015163_11	11.2\|6531617\|27\|CP015163\|CRISPRCasFinder	6531617-6531643	27	NC_023285	Streptomyces sp. F8 plasmid pFRL5, complete sequence	148595-148621	5	0.815
CP015163_2	2.2\|2307365\|25\|CP015163\|PILER-CR	2307365-2307389	25	NZ_CP015867	Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence	586979-587003	6	0.76
CP015163_6	6.1\|4307629\|33\|CP015163\|CRISPRCasFinder,CRT	4307629-4307661	33	MT711889	Pseudomonas phage Waldo5, complete genome	20713-20745	6	0.818
CP015163_6	6.1\|4307629\|33\|CP015163\|CRISPRCasFinder,CRT	4307629-4307661	33	NZ_CP054841	Acidovorax sp. 16-35-5 plasmid unnamed1, complete sequence	525310-525342	6	0.818
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NC_014310	Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence	1015843-1015872	6	0.8
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP022762	Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence	912851-912880	6	0.8
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP023017	Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence	984953-984982	6	0.8
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP014703	Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence	911948-911977	6	0.8
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP022760	Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence	917466-917495	6	0.8
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP022789	Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence	917456-917485	6	0.8
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP022771	Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence	912843-912872	6	0.8
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP022777	Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence	912861-912890	6	0.8
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP022799	Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence	912834-912863	6	0.8
CP015163_11	11.2\|6531617\|27\|CP015163\|CRISPRCasFinder	6531617-6531643	27	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	550896-550922	6	0.778
CP015163_11	11.2\|6531617\|27\|CP015163\|CRISPRCasFinder	6531617-6531643	27	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1363275-1363301	6	0.778
CP015163_11	11.2\|6531617\|27\|CP015163\|CRISPRCasFinder	6531617-6531643	27	NZ_CP032348	Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence	95564-95590	6	0.778
CP015163_11	11.2\|6531617\|27\|CP015163\|CRISPRCasFinder	6531617-6531643	27	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1581495-1581521	6	0.778
CP015163_11	11.2\|6531617\|27\|CP015163\|CRISPRCasFinder	6531617-6531643	27	NC_015409	Verrucosispora maris AB-18-032 plasmid pVMKU, complete sequence	18077-18103	6	0.778
CP015163_11	11.2\|6531617\|27\|CP015163\|CRISPRCasFinder	6531617-6531643	27	KX397369	Erwinia phage vB_EamM_Kwan, complete genome	88232-88258	6	0.778
CP015163_6	6.1\|4307629\|33\|CP015163\|CRISPRCasFinder,CRT	4307629-4307661	33	NZ_CP032324	Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence	347702-347734	7	0.788
CP015163_6	6.1\|4307629\|33\|CP015163\|CRISPRCasFinder,CRT	4307629-4307661	33	NZ_CP054620	Azospirillum oryzae strain KACC 14407 plasmid unnamed5, complete sequence	287216-287248	7	0.788
CP015163_6	6.2\|4307690\|33\|CP015163\|CRISPRCasFinder,CRT	4307690-4307722	33	NZ_CP019063	Rahnella sp. ERMR1:05 plasmid unnamed1, complete sequence	228076-228108	7	0.788
CP015163_6	6.3\|4307751\|32\|CP015163\|CRISPRCasFinder,CRT	4307751-4307782	32	NZ_CP053858	Rhizobium pusense strain 76 plasmid pR76, complete sequence	65681-65712	7	0.781
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_LR594663	Variovorax sp. RA8 plasmid 2	79251-79280	7	0.767
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP029832	Azospirillum ramasamyi strain M2T2B2 plasmid unnamed2, complete sequence	643394-643423	7	0.767
CP015163_11	11.2\|6531617\|27\|CP015163\|CRISPRCasFinder	6531617-6531643	27	NZ_CP032343	Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence	614092-614118	7	0.741
CP015163_11	11.2\|6531617\|27\|CP015163\|CRISPRCasFinder	6531617-6531643	27	NZ_CP012917	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence	114105-114131	7	0.741
CP015163_6	6.1\|4307629\|33\|CP015163\|CRISPRCasFinder,CRT	4307629-4307661	33	NZ_CP044425	Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence	157431-157463	8	0.758
CP015163_6	6.1\|4307629\|33\|CP015163\|CRISPRCasFinder,CRT	4307629-4307661	33	MT310008	Microvirus sp. isolate BS1_264, complete genome	3116-3148	9	0.727
CP015163_6	6.1\|4307629\|33\|CP015163\|CRISPRCasFinder,CRT	4307629-4307661	33	NZ_CP035511	Haematobacter massiliensis strain OT1 plasmid pOT1-1, complete sequence	274407-274439	9	0.727
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NC_018023	Mycolicibacterium chubuense NBB4 plasmid pMYCCH.02, complete sequence	119786-119815	9	0.7
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	876327-876356	9	0.7
CP015163_11	11.1\|6531560\|30\|CP015163\|CRISPRCasFinder	6531560-6531589	30	NZ_CP047219	Sphingobium yanoikuyae strain YC-JY1 plasmid unnamed1, complete sequence	31321-31350	9	0.7
CP015163_6	6.3\|4307751\|32\|CP015163\|CRISPRCasFinder,CRT	4307751-4307782	32	NZ_CP006370	Aureimonas sp. AU20 plasmid pAU20c, complete sequence	229767-229798	10	0.688

1. spacer 2.2|2307365|25|CP015163|PILER-CR matches to NZ_LN832562 (Paracoccus aminovorans isolate JCM7685 plasmid IV, complete sequence) position: , mismatch: 3, identity: 0.88

agcacgcacagcacccccgccccga	CRISPR spacer
aacacgagcagcacccccgccccga	Protospacer
*.**** .*****************

2. spacer 2.2|2307365|25|CP015163|PILER-CR matches to NZ_CP008890 (Dermacoccus nishinomiyaensis strain M25 plasmid unnamed, complete sequence) position: , mismatch: 3, identity: 0.88

agcacgcacagcacccccgccccga	CRISPR spacer
agcacgcacagcaaccccgccaaga	Protospacer
************* *******  **

3. spacer 2.2|2307365|25|CP015163|PILER-CR matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 4, identity: 0.84

agcacgcacagcacccccgccccga	CRISPR spacer
agcacgcacagcacccccgcgcact	Protospacer
******************** *

4. spacer 2.2|2307365|25|CP015163|PILER-CR matches to NC_014213 (Meiothermus silvanus DSM 9946 plasmid pMESIL01, complete sequence) position: , mismatch: 4, identity: 0.84

agcacgcacagcacccccgccccga	CRISPR spacer
agcacgcacagcacccccgcgcact	Protospacer
******************** *

5. spacer 2.2|2307365|25|CP015163|PILER-CR matches to NZ_CP032348 (Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence) position: , mismatch: 4, identity: 0.84

agcacgcacagcacccccgccccga	CRISPR spacer
ggcccccacagcacccccgccccgg	Protospacer
.** * ******************.

6. spacer 2.2|2307365|25|CP015163|PILER-CR matches to NZ_CP012748 (Paraburkholderia caribensis MBA4 plasmid unnamed, complete sequence) position: , mismatch: 5, identity: 0.8

agcacgcacagcacccccgccccga	CRISPR spacer
gcgccgcacagcgcccccgccccga	Protospacer
.   ********.************

7. spacer 11.2|6531617|27|CP015163|CRISPRCasFinder matches to NZ_CP049361 (Deinococcus wulumuqiensis R12 plasmid unnamed4, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgggcgggccgctgggtctgggat	CRISPR spacer
acctgggcgggccgctgggtcaggccg	Protospacer
 ******************** **

8. spacer 11.2|6531617|27|CP015163|CRISPRCasFinder matches to NC_023285 (Streptomyces sp. F8 plasmid pFRL5, complete sequence) position: , mismatch: 5, identity: 0.815

tcctgggcgggccgctgggtctgggat	CRISPR spacer
tcctgggcgggcggctgcgtctggtca	Protospacer
************ **** ******

9. spacer 2.2|2307365|25|CP015163|PILER-CR matches to NZ_CP015867 (Streptomyces parvulus strain 2297 plasmid pSPA1, complete sequence) position: , mismatch: 6, identity: 0.76

agcacgcacagcacccccgccccga	CRISPR spacer
cctggccacagcacccccgccccga	Protospacer
  ..  *******************

10. spacer 6.1|4307629|33|CP015163|CRISPRCasFinder,CRT matches to MT711889 (Pseudomonas phage Waldo5, complete genome) position: , mismatch: 6, identity: 0.818

ggccgggctggtgccgctggagacgctggagtc	CRISPR spacer
ggtgctgctgctgccgctggagccgctggagtc	Protospacer
**.   **** *********** **********

11. spacer 6.1|4307629|33|CP015163|CRISPRCasFinder,CRT matches to NZ_CP054841 (Acidovorax sp. 16-35-5 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.818

ggccgggctggtgccgctggagacgctggagtc	CRISPR spacer
ggtggcgctgatgtcgctggagacgctggagtt	Protospacer
**. * ****.**.******************.

12. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NC_014310 (Ralstonia solanacearum PSI07 plasmid mpPSI07, complete sequence) position: , mismatch: 6, identity: 0.8

gcctgggcggccgctttggagcg---gcaggtc	CRISPR spacer
gcctgggcggccactttggtgcgcatgcgg---	Protospacer
************.****** ***   **.*

13. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP022762 (Ralstonia solanacearum strain T95 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.8

gcctgggcggccgctttggagcg---gcaggtc	CRISPR spacer
gcctgggcggccactttggcgcgcatgcgg---	Protospacer
************.****** ***   **.*

14. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP023017 (Ralstonia solanacearum strain SL3022 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.8

gcctgggcggccgctttggagcg---gcaggtc	CRISPR spacer
gcctgggcggccactttggcgcgcatgcgg---	Protospacer
************.****** ***   **.*

15. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP014703 (Ralstonia solanacearum strain KACC 10722 plasmid, complete sequence) position: , mismatch: 6, identity: 0.8

gcctgggcggccgctttggagcg---gcaggtc	CRISPR spacer
gcctgggcggccactttggcgcgcatgcgg---	Protospacer
************.****** ***   **.*

16. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP022760 (Ralstonia solanacearum strain T98 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.8

gcctgggcggccgctttggagcg---gcaggtc	CRISPR spacer
gcctgggcggccactttggcgcgcatgcgg---	Protospacer
************.****** ***   **.*

17. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP022789 (Ralstonia solanacearum strain SL3175 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.8

gcctgggcggccgctttggagcg---gcaggtc	CRISPR spacer
gcctgggcggccactttggcgcgcatgcgg---	Protospacer
************.****** ***   **.*

18. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP022771 (Ralstonia solanacearum strain T51 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.8

gcctgggcggccgctttggagcg---gcaggtc	CRISPR spacer
gcctgggcggccactttggcgcgcatgcgg---	Protospacer
************.****** ***   **.*

19. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP022777 (Ralstonia solanacearum strain T11 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.8

gcctgggcggccgctttggagcg---gcaggtc	CRISPR spacer
gcctgggcggccactttggcgcgcatgcgg---	Protospacer
************.****** ***   **.*

20. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP022799 (Ralstonia solanacearum strain SL2064 plasmid unnamed, complete sequence) position: , mismatch: 6, identity: 0.8

gcctgggcggccgctttggagcg---gcaggtc	CRISPR spacer
gcctgggcggccactttggcgcgcatgcgg---	Protospacer
************.****** ***   **.*

21. spacer 11.2|6531617|27|CP015163|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.778

tcctgggcgggccgctgggtctgggat	CRISPR spacer
tcctcggcgggcggctgggtctgaacg	Protospacer
**** ******* **********..

22. spacer 11.2|6531617|27|CP015163|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.778

tcctgggcgggccgctgggtctgggat	CRISPR spacer
tcctcggcgggcggctgggtctgaacg	Protospacer
**** ******* **********..

23. spacer 11.2|6531617|27|CP015163|CRISPRCasFinder matches to NZ_CP032348 (Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence) position: , mismatch: 6, identity: 0.778

tcctgggcgggccgctgggtctgggat	CRISPR spacer
ccgcgggcgggccgctggggctggggc	Protospacer
.* .*************** *****..

24. spacer 11.2|6531617|27|CP015163|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 6, identity: 0.778

tcctgggcgggccgctgggtctgggat	CRISPR spacer
tcctcggcgggcggctgggtctgaacg	Protospacer
**** ******* **********..

25. spacer 11.2|6531617|27|CP015163|CRISPRCasFinder matches to NC_015409 (Verrucosispora maris AB-18-032 plasmid pVMKU, complete sequence) position: , mismatch: 6, identity: 0.778

tcctgggcgggccgctgggtctgggat	CRISPR spacer
ggctggccgggccgctgggtctgtcgt	Protospacer
  **** ****************  .*

26. spacer 11.2|6531617|27|CP015163|CRISPRCasFinder matches to KX397369 (Erwinia phage vB_EamM_Kwan, complete genome) position: , mismatch: 6, identity: 0.778

tcctgggcgggccgctgggtctgggat	CRISPR spacer
ggtcggacgggccgctgggtctggtat	Protospacer
  ..**.***************** **

27. spacer 6.1|4307629|33|CP015163|CRISPRCasFinder,CRT matches to NZ_CP032324 (Azospirillum brasilense strain MTCC4035 plasmid p3, complete sequence) position: , mismatch: 7, identity: 0.788

ggccgggctggtgccgctggagacgctggagtc	CRISPR spacer
gatcgggctggggccgctggagccgctgctggc	Protospacer
*..******** ********** *****  * *

28. spacer 6.1|4307629|33|CP015163|CRISPRCasFinder,CRT matches to NZ_CP054620 (Azospirillum oryzae strain KACC 14407 plasmid unnamed5, complete sequence) position: , mismatch: 7, identity: 0.788

ggccgggctggtgccgctggagacgctggagtc	CRISPR spacer
gacggagcgggtggcgctggagacgctggagcg	Protospacer
*.* *.** **** *****************.

29. spacer 6.2|4307690|33|CP015163|CRISPRCasFinder,CRT matches to NZ_CP019063 (Rahnella sp. ERMR1:05 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.788

cgcggccagctccccgcggcgtaccggcaccat	CRISPR spacer
tgcggccagctcctcgcggcgtaacgtgaaaat	Protospacer
.************.********* **  *  **

30. spacer 6.3|4307751|32|CP015163|CRISPRCasFinder,CRT matches to NZ_CP053858 (Rhizobium pusense strain 76 plasmid pR76, complete sequence) position: , mismatch: 7, identity: 0.781

tggggcaggccaagagccatcgcgaccagatc--	CRISPR spacer
aggggcaggccaagtgcaatcgcgat--ggtcat	Protospacer
 ************* ** *******.  *.**

31. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_LR594663 (Variovorax sp. RA8 plasmid 2) position: , mismatch: 7, identity: 0.767

gcctgggcggccgctttggagcggcaggtc	CRISPR spacer
gcctgaacggccgctttggagcggtcgcgt	Protospacer
*****..*****************. *  .

32. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP029832 (Azospirillum ramasamyi strain M2T2B2 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

gcctgggcggccgctttggagcggcaggtc	CRISPR spacer
cgcccgccggccgccttggcgcggcaggtc	Protospacer
  *. * *******.**** **********

33. spacer 11.2|6531617|27|CP015163|CRISPRCasFinder matches to NZ_CP032343 (Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence) position: , mismatch: 7, identity: 0.741

tcctgggcgggccgctgggtctgggat	CRISPR spacer
cggcgggcgggccgctggggctggggc	Protospacer
.  .*************** *****..

34. spacer 11.2|6531617|27|CP015163|CRISPRCasFinder matches to NZ_CP012917 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence) position: , mismatch: 7, identity: 0.741

tcctgggcgggccgctgggtctgggat	CRISPR spacer
cggcgggcgggccgctggggctggggc	Protospacer
.  .*************** *****..

35. spacer 6.1|4307629|33|CP015163|CRISPRCasFinder,CRT matches to NZ_CP044425 (Paracoccus pantotrophus strain DSM 2944 plasmid pPAN2, complete sequence) position: , mismatch: 8, identity: 0.758

ggccgggctggtgccgctggagacgctggagtc	CRISPR spacer
ggccgggctggtgctgctggcgaccgcggcgct	Protospacer
**************.***** ***  .** *..

36. spacer 6.1|4307629|33|CP015163|CRISPRCasFinder,CRT matches to MT310008 (Microvirus sp. isolate BS1_264, complete genome) position: , mismatch: 9, identity: 0.727

ggccgggctggtgccgctggagacgctggagtc	CRISPR spacer
taagcggccggagccgctggagacgctggagcg	Protospacer
 .   ***.** *******************.

37. spacer 6.1|4307629|33|CP015163|CRISPRCasFinder,CRT matches to NZ_CP035511 (Haematobacter massiliensis strain OT1 plasmid pOT1-1, complete sequence) position: , mismatch: 9, identity: 0.727

ggccgggctggtgccgctggagacgctggagtc	CRISPR spacer
gacgacgctggagacgctggagacgctggaaat	Protospacer
*.* . ***** * ****************. .

38. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NC_018023 (Mycolicibacterium chubuense NBB4 plasmid pMYCCH.02, complete sequence) position: , mismatch: 9, identity: 0.7

gcctgggcggccgctttggagcggcaggtc	CRISPR spacer
atctgggccgccgctttggagctgctcaaa	Protospacer
..****** ************* **  .

39. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 9, identity: 0.7

gcctgggcggccgctttggagcggcaggtc	CRISPR spacer
gatatcgcggccgctttgcagcggcagaat	Protospacer
* .   ************ ********. .

40. spacer 11.1|6531560|30|CP015163|CRISPRCasFinder matches to NZ_CP047219 (Sphingobium yanoikuyae strain YC-JY1 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.7

gcctgggcggccgctttggagcggcaggtc	CRISPR spacer
cgctgggcggccccttgggagcggccacga	Protospacer
  ********** *** ******** .

41. spacer 6.3|4307751|32|CP015163|CRISPRCasFinder,CRT matches to NZ_CP006370 (Aureimonas sp. AU20 plasmid pAU20c, complete sequence) position: , mismatch: 10, identity: 0.688

tggggcaggccaagagccatcgcgaccagatc	CRISPR spacer
cccggctcgccaagagccatcgcgacacgccg	Protospacer
.  ***  ******************  * .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site	Prophage annotation

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage