CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP031131	Staphylococcus aureus strain E16SA093 chromosome, complete genome	6 crisprs	cas3,DEDDh,DinG,csa3,WYL	2	2	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP031131_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP031131_2

381608-381709

Orphan

Consensus_repeat	Method
TTATGAATTGAGTATTAAATTTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP031131_2

>merge|CP031131|2|381608-381709|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTGAAAGTAAATTACAGTTCTATAGGTTTATAAAAAATCAGTTTTTAAATCAAAGCTATATATGAATTGAGTATTAAATTTG

>CP031131|2|2|381608-381709|CRISPRCasFinder
TTATGAATTGAGTATTAAATTTG	AAAGTAAATTACAGTTCTATAGGTTTATAAAAAATCAGTTTTTAAATCAAAGCTAT
ATATGAATTGAGTATTAAATTTG

Protein	Signature genes	Signature genes Name	Protein_function
CP031131.1\|AXF99853.1\|381725_382682_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274008
CP031131.1\|AXF99847.1\|375925_377449_-\|alkyl-hydroperoxide-reductase-subunit-F	unknown	unknown	gnl\|CDD\|237942
CP031131.1\|AXF99852.1\|381141_381399_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXF99860.1\|389952_391059_+\|Abi-family-protein	unknown	unknown	gnl\|CDD\|377910
CP031131.1\|AXF99851.1\|380832_380931_+\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXF99862.1\|391853_392246_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXF99849.1\|378525_379281_+\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|380322
CP031131.1\|AXF99855.1\|383604_384012_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378584
CP031131.1\|AXG02150.1\|374191_374470_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXF99846.1\|373492_374119_-\|NDxxF-motif-lipoprotein	unknown	unknown	gnl\|CDD\|380196
CP031131.1\|AXF99850.1\|379359_380748_-\|L-cystine-transporter	unknown	unknown	gnl\|CDD\|224736
CP031131.1\|AXF99858.1\|386408_387875_+\|IMP-dehydrogenase	unknown	unknown	gnl\|CDD\|235507
CP031131.1\|AXF99854.1\|382799_383462_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXF99844.1\|372206_372788_+\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|223483
CP031131.1\|AXF99845.1\|372853_373237_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXF99861.1\|391505_391688_+\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXF99848.1\|377464_378034_-\|peroxiredoxin	unknown	unknown	gnl\|CDD\|211789
CP031131.1\|AXF99859.1\|387899_389441_+\|GMP-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl\|CDD\|234614
CP031131.1\|AXF99856.1\|384524_385103_+\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
CP031131.1\|AXF99857.1\|385102_386371_+\|purine-permease	unknown	unknown	gnl\|CDD\|274468

Protein	Function_ID	Function_description	E-value
CP031131.1\|AXF99853.1\|381725_382682_-\|hypothetical-protein	gnl\|CDD\|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	0.00304381
CP031131.1\|AXF99847.1\|375925_377449_-\|alkyl-hydroperoxide-reductase-subunit-F	gnl\|CDD\|237942	PRK15317, PRK15317, alkyl hydroperoxide reductase subunit F; Provisional.	0
CP031131.1\|AXF99860.1\|389952_391059_+\|Abi-family-protein	gnl\|CDD\|377910	pfam07751, Abi_2, Abi-like protein. This family, found in various bacterial species, contains sequences that are similar to the Abi group of proteins, which are involved in bacteriophage resistance mediated by abortive infection in Lactococcus species. The proteins are thought to have helix-turn-helix motifs, found in many DNA-binding proteins, allowing them to perform their function.	2.0112e-23
CP031131.1\|AXF99849.1\|378525_379281_+\|NADPH-dependent-oxidoreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	5.03864e-88
CP031131.1\|AXF99855.1\|383604_384012_-\|hypothetical-protein	gnl\|CDD\|378584	pfam11181, YflT, Heat induced stress protein YflT. YflT is a heat induced protein.	2.17298e-12
CP031131.1\|AXF99846.1\|373492_374119_-\|NDxxF-motif-lipoprotein	gnl\|CDD\|380196	NF033193, lipo_NDxxF, NDxxF motif lipoprotein. Members of this family are lipoproteins, about 200 amino acids long in precursor form, found in Staphylococcus aureus, Bacillus cereus, and various other Firmicutes. The protein family is named for one of its several highly conserved motifs.	1.15385e-71
CP031131.1\|AXF99850.1\|379359_380748_-\|L-cystine-transporter	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
CP031131.1\|AXF99844.1\|372206_372788_+\|histidine-phosphatase-family-protein	gnl\|CDD\|223483	COG0406, phoE, Broad specificity phosphatase PhoE and related phosphatases [General function prediction only].	1.30018e-49
CP031131.1\|AXF99858.1\|386408_387875_+\|IMP-dehydrogenase	gnl\|CDD\|235507	PRK05567, PRK05567, inosine 5'-monophosphate dehydrogenase; Reviewed.	0
CP031131.1\|AXF99848.1\|377464_378034_-\|peroxiredoxin	gnl\|CDD\|211789	TIGR03137, AhpC, peroxiredoxin. This peroxiredoxin (AhpC, alkylhydroperoxide reductase subunit C) is one subunit of a two-subunit complex with subunit F(TIGR03140). Usually these are found as an apparent operon. The gene has been characterized in Bacteroides fragilis, where it is important in oxidative stress defense. This gene contains two invariant cysteine residues, one near the N-terminus and one near the C-terminus, each followed immediately by a proline residue. [Cellular processes, Detoxification, Cellular processes, Adaptations to atypical conditions].	1.50623e-124
CP031131.1\|AXF99859.1\|387899_389441_+\|GMP-synthase-(glutamine-hydrolyzing)	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
CP031131.1\|AXF99856.1\|384524_385103_+\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	9.01486e-119
CP031131.1\|AXF99857.1\|385102_386371_+\|purine-permease	gnl\|CDD\|274468	TIGR03173, pbuX, xanthine permease. All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.	5.28569e-170

>CP031131.1|AXF99852.1|381141_381399_-|hypothetical-protein
MLVTDESHKCTLIFTFTTNAFLLKQKYLFTVAFELPPAHTNTQKMLILIRQNFLQRVCSKRLFKVDHLLSFHSINMRLAIFIKPP
>CP031131.1|AXF99851.1|380832_380931_+|hypothetical-protein
MQLNVNMMKFDRWHKGICKQIVLNLVEKGEKG
>CP031131.1|AXF99850.1|379359_380748_-|L-cystine-transporter
MNAFLTLINIIVLVIFIVILHMMARKHISFAKRVFTALGIGIVFGVLLHLVYGTHSNVITSTSDWFNIVGQGYVALLQMIVMPLIFISIVAAFTKIQIGEKFAKIGSLIFIFLIGTVTIAAIVGVVYALVFGLDASTINLGNAEQARGSEIAKQAKDLTAHTLPQQILELLPKNPFLDFTGQRATSTIAVVIFASFIGFAYLRVARKQPDHGELLKSAIDAIYSLVMAIVTFVLRLTPYGVLAIMANTLSTSDFGAIWTLGKFLIASYAALITMYIIHLVILSLLGISPIRYVKKTLEVLIFAFTSRSSAGALPLNVQTQTRRLGVPEGIANFAATFGLSIGQNGCAGIYPAMLAIMVAPVANVEIDLQFIVTLIAVVIISSFGVAGVGGGATFASILVLSTLNLPVALAGVLISVEPLIDMGRTALNVNDSMLAGTGTAKLTKHWDKDTFESNDNAALTSH
>CP031131.1|AXF99849.1|378525_379281_+|NADPH-dependent-oxidoreductase
MSEHVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKENLREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAENIAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPFDHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDMLEQLQKSGLIQR
>CP031131.1|AXF99848.1|377464_378034_-|peroxiredoxin
MSLINKEILPFTAQAFDPKKDQFKEVTQEDLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHFVHKAWHDHSDAISKITYTMIGDPSQTITRNFDVLDEATGLAQRGTFIIDPDGVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQPGLDLVGKI
>CP031131.1|AXF99847.1|375925_377449_-|alkyl-hydroperoxide-reductase-subunit-F
MLNADLKQQLKQLLELMEGNVEFVASLGSDEKSKELKELLTEISDMSPRLSLSEKSLKRTPSFSVNRPGEETGVTFAGIPLGHEFNSLVLAILQVSGRAPKEKQSIIDQIKNLEGSFHFETFISLTCQKCPDVVQALNLMSVINPNITHSMIDGAVFREESENIMAVPAVFLNGEEFGNGRMTIQDILSKLGSTADASEFENKEPYDVLIVGGGPASGSAAIYTARKGLRTGIVADRIGGQVNDTAGIENFITVKETTGSEFSSNLAAHIDQYDIDAMTGIRATDIEKTDEAIKVTLENGAVLESKTVIIATGAGWRKLNIPGEEQLINKGVAFCPHCDGPLFENKDVAVIGGGNSGVEAAIDLAGIVNHVTLFEFASELKADNVLQDRLRSLSNVDIKTNAKTTEVVGEDHVTGIRYEDMSTGEEHLLNLDGIFVQIGLLPNTSWLKDAVELNERGEIVIDRNNNTNVPGIFAAGDVTDQKNKQIIISMGAGANAALNAFDYIIRN
>CP031131.1|AXG02150.1|374191_374470_-|hypothetical-protein
MKSDQAIKEFTSYLRKQINMKNDIEKEKYVNEIIMLLRTIPTSKLIQPIMQLFIDNAILNNVQNDALLIEKATHARNHLRLWSLQGHRDIPN
>CP031131.1|AXF99846.1|373492_374119_-|NDxxF-motif-lipoprotein
MKKRLLLSTFLASALILTGCASDQSDNEDHHTSTGIHAPKSAKKLETKDIFNSDKKNSDISDAEMKQAIEKYLSVNSDILDNKYIMQHKLDKQIDSQTKVTEKQAETLSHLSNLAVKNDLHFKKFVTENNIPKEYKKPVELMMNYFKALNSTIANVDEDIEKLSYQPQNKINVVDVPTKYAGDVNKKQQDKIKDFLKSKGIKSDVIDK
>CP031131.1|AXF99845.1|372853_373237_-|hypothetical-protein
MKVRITFIILSILSTIVCLFLAAMHPTGPSTVTFEQPYLFTLNIIIMVLVALPSLVLAIYDYMSFRISSAILQFLGAISWFFLSLILSLTQFTPFTLASFITSIILFTSTIITLAIGGKSVDKNDSH
>CP031131.1|AXF99844.1|372206_372788_+|histidine-phosphatase-family-protein
MTIYLVRHGESKSNYDNKHFRSYFCGQLDVPLTDTGTKSADDLCDYFKEKQIKHVYVSDLLRTQQTFEHIFPYDIASTTTPLLRERSLGVFEGEYKDEISANPKYEKYFNDPNFKDFRHSFSQKAPEGESYEDVYQRVEHFMNHVVNEDTQQDDIVIVAHQVVIRCLMVYFNNVSREEAVDLKVENCKPYIIE
>CP031131.1|AXF99853.1|381725_382682_-|hypothetical-protein
MLTKEFAQRVELSEKQVRKIVQHLEERGYQLSKTEYRGREATDFKEEDIELFKDIADKVKQTNSYDLAFDELEKEKDFLQVIVKNDDKNLPTNQNVAQLVEDLRLEIQKMREERHLFGQMMNQVHQQQQELKELQNQLTSKIDSNSESLKAIQTSQEAIQEAQASQAKVLAESTNKVEKNAVTEDKADSKDSKVAGVTTSTDAKTDTKAENAGDGTATKVDKEDQISATEAIEKASVEQSKNENAAETSNKEATVDADAQHDAEQQVAEAHAEASKQATSNDSLEAKAENDSTASQSEMSEPKPQEEKKGFFARLFNL
>CP031131.1|AXF99854.1|382799_383462_-|hypothetical-protein
MEFKTIQSVKDPHYNEALKLYDTKLNLSLTEDKRIIKRSLENNKTENDYVFIVGLENDVVVSLATAHYEATTNSAFLIYLFAKDLPNHDELMTQTLHQIEHELNLLSNLVHSRSINFLMMEVPKEPADLTQDNGLIIEHRRQFLYEHQFERQTEIDYIHPTNDGHTKKVDLFLKKNIKLTKDIYGTSVKSNYILKYVFANGIAREIIYALLEEMDLRKPF
>CP031131.1|AXF99855.1|383604_384012_-|hypothetical-protein
MADITVVNDTGELYNVINQKKSEGYLESELTIISKSKLHLNDLHDSEISLISTSGTFSDRMTKLLTGEDGEHAVLSRYNLAPDELEKYKQLILDDKMLVVAVRDKSSHKEVQEHNSAYEEIDITHFAEASKGPKA
>CP031131.1|AXF99856.1|384524_385103_+|xanthine-phosphoribosyltransferase
MELLGQKVKEDGVVIDEKILKVDGFLNHQIDAKLMNEVGRTFYEQFKDKGITKILTIEASGIAPAIMAALHFDVPCLFAKKAKPSTLTDGYYETSIHSFTKNKTSTVIVSKEFLSEEDTVLIIDDFLANGDASLGLYDIAQQANAKTAGIGIVVEKSFQNGHQRLEEAGLTVSSLCKVASLEGNKVTLVGEE
>CP031131.1|AXF99857.1|385102_386371_+|purine-permease
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILVLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFIVAIVSLIESTGVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLIICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEENVK
>CP031131.1|AXF99858.1|386408_387875_+|IMP-dehydrogenase
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLVEAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQITKESPNYSF
>CP031131.1|AXF99859.1|387899_389441_+|GMP-synthase-(glutamine-hydrolyzing)
MEMAKEQELILVLDFGSQYNQLITRRIREMGVYSELHDHEISIEEIKKMNPKGIILSGGPNSVYEEGSFTIDPEIYNLGIPVLGICYGMQLTTKLLGGKVERANEREYGKAIINAKSDELFAGLPAEQTVWMSHSDKVIEIPEGFEVIADSPSTDYAAIEDKKRRIYGVQFHPEVRHTEYGNDLLNNFVRRVCDCKGQWTMENFIEIEIEKIRQRVGDRRVLCAMSGGVDSSVVAVLLHKAIGDQLTCIFVDHGLLRKGEGDMVMEQFGEGFNMNIIRVNAKDRFMNKLKGVSDPEQKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDVIESGTKTAQTIKSHHNVGGLPEDMEFELIEPINTLFKDEVRKLGIELGIPEHLVWRQPFPGPGLGIRVLGEITEDKLEIVRESDAILRQVIREEGLEREIWQYFTVLPNIQSVGVMGDYRTYDHTVGIRAVTSIDGMTSDFARIDWEVLQKISSRIVNEVDHVNRVVYDITSKPPSTIEWE
>CP031131.1|AXF99860.1|389952_391059_+|Abi-family-protein
MDKSLEINLKELESIMYKEKVIDVKEYDNLKVTFETLNDAPKSEIPTPFTIEQMLYKLETKNLYFPEIKSKEKCVELLHSVGYYNLKHFMYNEFGKDEPKNFDEVYILYKFDRYLLKQLFSLVNMLETHIRNIILEVYMLEIEYNNKPSTLFYLDKDLYFEKVNDEYKYSAKKLKEFNRLQNVFWRAIEKKKSNDNVKHNIKKYNIIPAWVLFQNFSFGDLSTFYRTTLPTYRNKVSKRIENLIEKNTGISIKLPEKLLCAWLNSIRFLRNRIAHTDIIYGINFTNTCAKHHSDEEMYVNIEKYKYQQRLVTFLLAMKKIFMSMPENNIIEWNETLTKIENKCSEHNFIKLSRLGVIENNLSYFKITK
>CP031131.1|AXF99861.1|391505_391688_+|hypothetical-protein
MFLIWATSCYEMIGVIYVEIGVPISLCWGPAVNYCQYKIVEPTILILCPRLGFLRLVKYL
>CP031131.1|AXF99862.1|391853_392246_-|hypothetical-protein
MLEDNGDIRLLYQSIEELASVLGQSQFETKTVSLIFVQMDLRYSVFEKVQTDFMKYLAHKNSDEIKYIDLIKIIENALPEDKELSINVINSIIIGFANNYYPILQSLVPEIQSSYGITINKNFNIDSIDF

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Crispr_ID: CP031131_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP031131_3

1118467-1118559

Orphan

Consensus_repeat	Method
TCATAATGATTAAAAATCAAAGAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP031131_3

>merge|CP031131|3|1118467-1118559|CRISPRCasFinder
TCATAATGATTAAAAATCAAAGAGGAACAGCGGAATACAGATGATGCTTCGCATCACTGCATAAAAGCCTCTAATGATTAAAAATCAAAGAGG

>CP031131|3|3|1118467-1118559|CRISPRCasFinder
TCATAATGATTAAAAATCAAAGAGG	AACAGCGGAATACAGATGATGCTTCGCATCACTGCATAAAAGC
CTCTAATGATTAAAAATCAAAGAGG

Protein	Signature genes	Signature genes Name	Protein_function
CP031131.1\|AXG00577.1\|1127705_1128320_+\|succinate-dehydrogenase	unknown	unknown	gnl\|CDD\|239577
CP031131.1\|AXG00567.1\|1115713_1118116_+\|phenylalanine--tRNA-ligase-subunit-beta	unknown	unknown	gnl\|CDD\|234804
CP031131.1\|AXG00574.1\|1124962_1125277_+\|thiol-reductase-thioredoxin	unknown	unknown	gnl\|CDD\|200072
CP031131.1\|AXG00566.1\|1114655_1115714_+\|phenylalanine--tRNA-ligase-subunit-alpha	unknown	unknown	gnl\|CDD\|234780
CP031131.1\|AXG00560.1\|1110157_1111036_+\|heme-uptake-system-protein-IsdE	unknown	unknown	gnl\|CDD\|274706
CP031131.1\|AXG00575.1\|1125339_1125435_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG00570.1\|1119858_1120125_+\|cell-division-protein-ZapA	unknown	unknown	gnl\|CDD\|172616
CP031131.1\|AXG00559.1\|1109084_1110161_+\|heme-ABC-transporter-permease	unknown	unknown	unknown
CP031131.1\|AXG00579.1\|1130137_1130953_+\|succinate-dehydrogenase-iron-sulfur-subunit	unknown	unknown	gnl\|CDD\|181515
CP031131.1\|AXG00568.1\|1118167_1118296_+\|acyltransferase	unknown	unknown	unknown
CP031131.1\|AXG00563.1\|1112828_1113152_+\|staphylobilin-forming-heme-oxygenase-IsdG	unknown	unknown	gnl\|CDD\|139480
CP031131.1\|AXG00576.1\|1125600_1127382_+\|excinuclease-ABC-subunit-C	unknown	unknown	gnl\|CDD\|234792
CP031131.1\|AXG00561.1\|1111045_1112014_+\|iron-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223682
CP031131.1\|AXG00573.1\|1122441_1124790_+\|endonuclease-MutS2	unknown	unknown	gnl\|CDD\|234750
CP031131.1\|AXG00578.1\|1128371_1130138_+\|succinate-dehydrogenase-flavoprotein-subunit	unknown	unknown	gnl\|CDD\|236319
CP031131.1\|AXG00565.1\|1113535_1114276_+\|RNA-methyltransferase	unknown	unknown	gnl\|CDD\|223640
CP031131.1\|AXG00572.1\|1120719_1122432_+\|DNA-polymerase/3'-5'-exonuclease-PolX	unknown	unknown	gnl\|CDD\|236311
CP031131.1\|AXG00564.1\|1113188_1113296_+\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG00571.1\|1120125_1120647_+\|CvpA-family-protein	unknown	unknown	gnl\|CDD\|224205
CP031131.1\|AXG00562.1\|1112075_1112810_+\|SrtB-family-sortase	unknown	unknown	gnl\|CDD\|226898

Protein	Function_ID	Function_description	E-value
CP031131.1\|AXG00577.1\|1127705_1128320_+\|succinate-dehydrogenase	gnl\|CDD\|239577	cd03497, SQR_TypeB_1_TM, Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis SQR reduces low potential quinones such as menaquinone. SQR is also called succinate dehydrogenase (Sdh) or Complex II and is part of the citric acid cycle and the aerobic respiratory chain. SQR is composed of a flavoprotein catalytic subunit, an iron-sulfur protein and one or two hydrophobic transmembrane subunits. Members of this subfamily are classified as Type B as they contain one transmembrane subunit and two heme groups. The heme and quinone binding sites reside on the transmembrane subunit. The transmembrane subunit of Bacillus subtilis SQR is also called Sdh cytochrome b558 subunit. The structural arrangement allows efficient electron transfer between the catalytic subunit, through iron-sulfur centers, and the transmembrane subunit containing the electron acceptor (quinone). The reversible reduction of quinone is an essential feature of respiration, allowing transfer of electrons between respiratory complexes.	2.37018e-87
CP031131.1\|AXG00567.1\|1115713_1118116_+\|phenylalanine--tRNA-ligase-subunit-beta	gnl\|CDD\|234804	PRK00629, pheT, phenylalanyl-tRNA synthetase subunit beta; Reviewed.	0
CP031131.1\|AXG00574.1\|1124962_1125277_+\|thiol-reductase-thioredoxin	gnl\|CDD\|200072	TIGR01068, Thioredoxin-like_protein_slr0233, thioredoxin. Several proteins, such as protein disulfide isomerase, have two or more copies of a domain closely related to thioredoxin. This model is designed to recognize authentic thioredoxin, a small protein that should be hit exactly once by this model. Any protein that hits once with a score greater than the second (per domain) trusted cutoff may be taken as thioredoxin. [Energy metabolism, Electron transport].	3.26685e-48
CP031131.1\|AXG00566.1\|1114655_1115714_+\|phenylalanine--tRNA-ligase-subunit-alpha	gnl\|CDD\|234780	PRK00488, pheS, phenylalanyl-tRNA synthetase subunit alpha; Validated.	0
CP031131.1\|AXG00560.1\|1110157_1111036_+\|heme-uptake-system-protein-IsdE	gnl\|CDD\|274706	TIGR03659, heme_ABC_transporter_heme-binding_protein_isdE, heme ABC transporter, heme-binding protein isdE. This family of ABC substrate-binding proteins is observed primarily in close proximity with proteins localized to the cell wall and bearing the NEAT (NEAr Transporter, pfam05031) heme-binding domain. IsdE has been shown to bind heme and is involved in the process of scavenging heme for the purpose of obtaining iron.	9.77537e-156
CP031131.1\|AXG00570.1\|1119858_1120125_+\|cell-division-protein-ZapA	gnl\|CDD\|172616	PRK14126, PRK14126, cell division protein ZapA; Provisional.	1.04877e-21
CP031131.1\|AXG00563.1\|1112828_1113152_+\|staphylobilin-forming-heme-oxygenase-IsdG	gnl\|CDD\|139480	PRK13312, PRK13312, staphylobilin-forming heme oxygenase IsdG.	3.35893e-67
CP031131.1\|AXG00576.1\|1125600_1127382_+\|excinuclease-ABC-subunit-C	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
CP031131.1\|AXG00561.1\|1111045_1112014_+\|iron-ABC-transporter-permease	gnl\|CDD\|223682	COG0609, FepD, ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism].	1.25627e-60
CP031131.1\|AXG00573.1\|1122441_1124790_+\|endonuclease-MutS2	gnl\|CDD\|234750	PRK00409, PRK00409, recombination and DNA strand exchange inhibitor protein; Reviewed.	0
CP031131.1\|AXG00578.1\|1128371_1130138_+\|succinate-dehydrogenase-flavoprotein-subunit	gnl\|CDD\|236319	PRK08641, sdhA, succinate dehydrogenase flavoprotein subunit; Reviewed.	0
CP031131.1\|AXG00565.1\|1113535_1114276_+\|RNA-methyltransferase	gnl\|CDD\|223640	COG0566, SpoU, rRNA methylases [Translation, ribosomal structure and biogenesis].	2.00285e-77
CP031131.1\|AXG00572.1\|1120719_1122432_+\|DNA-polymerase/3'-5'-exonuclease-PolX	gnl\|CDD\|236311	PRK08609, PRK08609, DNA polymerase/3'-5' exonuclease PolX.	0
CP031131.1\|AXG00579.1\|1130137_1130953_+\|succinate-dehydrogenase-iron-sulfur-subunit	gnl\|CDD\|181515	PRK08640, sdhB, succinate dehydrogenase iron-sulfur subunit; Reviewed.	0
CP031131.1\|AXG00571.1\|1120125_1120647_+\|CvpA-family-protein	gnl\|CDD\|224205	COG1286, CvpA, Uncharacterized membrane protein, required for colicin V production [General function prediction only].	4.13485e-29
CP031131.1\|AXG00562.1\|1112075_1112810_+\|SrtB-family-sortase	gnl\|CDD\|226898	COG4509, COG4509, Uncharacterized protein conserved in bacteria [Function unknown].	2.78558e-128

>CP031131.1|AXG00568.1|1118167_1118296_+|acyltransferase
MGVYFWVHQLGSNAFKKSKRNSGIQMMLCTTAYKVILMSKAN
>CP031131.1|AXG00567.1|1115713_1118116_+|phenylalanine--tRNA-ligase-subunit-beta
MLISNEWLKEYVTIDDSVSNLAERITRTGIEVDDLIDYTKDIKNLVVGFVKSKEKHPDADKLNVCQVDIGEDEPVQIVCGAPNVDAGQYVIVAKVGGRLPGGIKIKRAKLRGERSEGMICSLQEIGISSNYIPKSFESGIYVFSEAQVPGTDALQALYLDDQVMEFDLTPNRADALSMIGTAYEVAALYNTKMTKPDTTSNELELSANNELTVTIENEDKVPYYSARVVHDVTIEPSPIWMQARLIKAGIRPINNVVDISNYVLLEYGQPLHMFDQDAIGSQQIVVRQANEGEKMTTLDGTERELLTSDIVITNGQTPIALAGVMGGDFSEVKEQTSNIVIEGAIFDPVSIRHTSRRLNLRSESSSRFEKGIATEFVDEAVDRACYLLQTYANGKVLKDRVSSGELGAFITPIDITADKINRTIGFDLSQNDIVTIFNQLGFDTEINDDVITVQVPSRRKDITIKEDLIEEVARIYGYDDIPSTLPVFEKVTSGQLTDRQYKTRMVKEVLEGAGLDQAITYSLVSKEDATAFSMQQRQTIDLLMPMSEAHASLRQSLLPHLIEAASYNVARKNKDVKLFEIGNVFFANGEGELPDQVEYLSGILTGDYVVNQWQGKKETVDFYLAKGIVDRVSEKLNLEFSYRRADIDGLHPGRTAEILLENKVVGFIGELHPTLAADNDLKRTYVFELNFDALMAVSVGYINYQPIPRFPGMSRDIALEVDQNIPAADLLSTIHAHGGNILKDTLVFDVYQGEHLEKGKKSIAIRLNYLDTEETLTDERVSKVQAEIEAALIEHGAVIR
>CP031131.1|AXG00566.1|1114655_1115714_+|phenylalanine--tRNA-ligase-subunit-alpha
MSEQQTMSELKQQALVDINEANDERALQEVKVKYLGKKGSVSGLMKLMKDLPNEEKPAFGQKVNELRQTIQNELDERQQMLVKEKLNKQLAEETIDVSLPGRHIEIGSKHPLTRTIEEIEDLFLGLGYEIVNGYEVEQDHYNFEMLNLPKSHPARDMQDSFYITDEILLRTHTSPVQARTMESRHGQGPVKIICPGKVYRRDSDDATHSHQFTQIEGLVVDKNVKMSDLKGTLELLAKKLFGADREIRLRPSYFPFTEPSVEVDVSCFKCKGKGCNVCKHTGWIEILGAGMVHPNVLEMAGFDSSEYSGFAFGMGPDRIAMLKYGIEDIRHFYTNDVRFLDQFKAVEDRGDM
>CP031131.1|AXG00565.1|1113535_1114276_+|RNA-methyltransferase
MEQITSAQNNRIKQANKLKKKRERDKTGLALIEGVHLIEEAYQSGIVITQLFAIEPARLDQQIIAYAQEVFEINMKVAESLSGTVTPQGFFAIIEKPHYDISKAQQVLLIDRVQDPGNLGTLIRTADAAGMDAVIMEKGTTDPYQDKVLRASQGSVFHLPVMIQDLDTFITQFNGPVYGTALENAVAYKEVTSSDSFALLLGNEGEGVNPELLAHTTQNLIIPIYGKAESLNVAIAGSILLYHLKG
>CP031131.1|AXG00564.1|1113188_1113296_+|hypothetical-protein
MVLLAFVTTIHDTDDGRFFNEHKHANNKLLKHSLI
>CP031131.1|AXG00563.1|1112828_1113152_+|staphylobilin-forming-heme-oxygenase-IsdG
MKFMAENRLTLTKGTAKDIIERFYTRHGIETLEGFDGMFVTQTLEQEDFDEVKILTVWKSKQAFTDWLKSDVFKAAHKHVRSKNEDESSPIINNKVITYDIGYSYMK
>CP031131.1|AXG00562.1|1112075_1112810_+|SrtB-family-sortase
MRMKRFLTIVQILLVVIIIIFGYKIVQTYIEDKQERANYEKLQQKFQMLMSKHQAHVRPQFESLEKINKDIVGWIKLSGTSLNYPVLQGKTNHDYLNLDFEREHRRKGSIFMDFRNELKNLNHNTILYGHHVGDNTMFDVLEDYLKQSFYEKHKIIEFDNKYGKYQLQVFSAYKTTTKDNYIRTDFENDQDYQQFLDETKRKSVINSDVNVTVKDRIMTLSTCEDAYSETTKRIVVVAKIIKVS
>CP031131.1|AXG00561.1|1111045_1112014_+|iron-ABC-transporter-permease
MMIKNKKKLLFLCLLVILIATAYISFVTGTIKLSFNDLFTKFTTGSNEAVDSIIDLRLPRILIALMVGAMLAVSGALLQAALQNPLAEANIIGVSSGALIMRALCMLFIPQLYFYLPLLSFIGGLIPFLIIILLHSKFRFNAVSMILVGVALFVLLNGVLEILTQNPLMKIPQGLTMKIWSDVYILAVSALLGLILTLLLSPKLNLLNLDDIQARSIGFNIDRYRWLTGLLAVFLASATVAIVGQLAFLGIIVPHVVRKLVGGNYRVLIPFSTVIGAWLLLVADLLGRVIQPPLEIPANAILMIVGGPMLICLICQSQRNRI
>CP031131.1|AXG00560.1|1110157_1111036_+|heme-uptake-system-protein-IsdE
MRIIKYLTILVISVVILTSCQSSSSQESTKSGEFRIVPTTVALTMTLDKLDLPIVGKPTSYKTLPNRYKDVPEIGQPMEPNVEAVKKLKPTHVLSVSTIKDEMQPFYKQLNMKGYFYDFDSLKGMQKSITQLGDQFNRKAQAKELNDHLNSVKQKIENKAAKQKKHPKVLILMGVPGSYLVATDKSYIGDLVKIAGGENVIKVKDRQYISSNTENLLNINPDIILRLPHGMPEEVKKMFQKEFKQNDIWKHFKAVKNNHVYDLEEVPFGITANVDADKAMTQLYDLFYKDKK
>CP031131.1|AXG00559.1|1109084_1110161_+|heme-ABC-transporter-permease
MRNVKQIATKSIIAIISLGILTYTTMIGSVLADEIKYPSAKFNQPEAKDKTELTTSIFDEKIKENKALELLIFNQENKNVTEEQKLVDEKAQLISDMTGKIYLQVKLKGQIDKEQLVFQNDKNEEFPFVIKDEKDDTIVRILIEQHMDKINMHVKTLAEKKNLDNKEMVYSIHFKEKKVQHDDAKEVPSKHQNQENNQDQLKKDIDDKKDSQKSDTKERRTSLFTEKGLNDIPVQKDKVQQDSNKKIENERPKASGTLKVENSPPTIKKVENNHKEQPKHKDEKSKKEKKKVVEKEKALPAFNRDDDSKNSSQLSSDIKELDEPNHKKQYILFAAGIVLATILLISAHLYSRKRGNQV
>CP031131.1|AXG00570.1|1119858_1120125_+|cell-division-protein-ZapA
MAQFKNKVNVSINDQLFTIVGEDNPEHIRYVAHLVDDKIKELGYKAAGLDTSRKAILTAVNIMHEKVLLEEENRRLKQQIHKLQQREQ
>CP031131.1|AXG00571.1|1120125_1120647_+|CvpA-family-protein
MVIDFIIIIFFVYFVIVGFRRGFWLSMIHLSATIVSLWIASQFYKSIVERLIVFIPYPKTTAFNTTFAFHFNHLQNRFEAIVAFLMITLFCKFILYLIIVTFDKIIAYQNIHIFSRAMGMIVGVFMTIIVLHFTLYLLALYPNEALQHQLKISIVSHSLIFHIPYLSAFTINL
>CP031131.1|AXG00572.1|1120719_1122432_+|DNA-polymerase/3'-5'-exonuclease-PolX
MTKKDVIKLLEQIATYMELKGENTFKISAYRKAAQSLELDERPLDEISDVTELKGIGKGVAEVINDYRETGESQYLQQLQEEVPEGLIPLLKIQGLGSKKIAKLYKELNIVDKASLQVACENGKVSELSGFAKKTEQNILEAVKQLGAKKDRYPIDQMRRLNQEIIDYIDTLNYIDQYSSAGSFRRFKEMSKDLDFIISTDNPKAVQQQLLNIPNKVKEVAVGNTKVSLELAYDDETIGVDFRLIEPSAFYHTLQHFTGSKEHNIRIRQLAKARDEKVSEYGIEQADGTLIQYDSEAKIYEHFNVNFIPPAMREDGSEFDKDLSNIITIDDINGDIHMHTTYSDGAFSIRDMVEANIAKGYKFMVITDHSQSLRVANGLQVERLLRQNEEIKALDKEYSEIDIYSGTEMDILPDGSLDYDDEILAQLDYVIGAIHQSFNQSEEQIMERLANACRNPYVRHIAHPTGRIIGRRDGYKPNIEQLMALAEETNTVLEINANPHRLDLNADIVRKYPNVKLTINTDAHHTNHLDFMNYGVATAQKGFVTKDRVINALSREAFKDFIENNIKLKK
>CP031131.1|AXG00573.1|1122441_1124790_+|endonuclease-MutS2
MRQKTLDVLEFEKIKSLVANETISDLGLEKVNQMMPATNFETVVFQMEETDEIAQIYNKHRLPSLSGLSKVSAFIHRADIGGVLNVSELNLIKRLIQVQNQFKTFYNQLVEEDEGVKYPILDDKMNQLPVLTDLFQQINETCDTYDLYDNASYELQGIRSKISSTNQRIRQNLDRIVKSQANQKKLSDAIVTVRNERNVIPVKAEYRQDFNGIVHDQSASGQTLYIEPSSVVEMNNQISRLRHDEAIEKERILTQLTGYVAADKDALLVAEQVMGQLDFLIAKARYSRSIKGTKPIFKEERTVYLPKAYHPLLNRETVVANTIEFMEDIETVIITGPNTGGKTVTLKTLGLIIVMAQSGLLIPTLDGSQLSVFKNVYCDIGDEQSIEQSLSTFSSHMTNIVEILKHADKHSLVLFDELGAGTDPSEGAALAMSILDHVRKIGSLVMATTHYPELKAYSYNREGVMNASVEFDVDTLSPTYKLLMGVPGRSNAFDISKKLGLSLNIINKAKTMIGTDEKEINEMIESLERNYKRVETQRLELDRLVKEAEQVHDDLSKQYQQFQNYEKSLIEEAKEKANQKIKAATKEADDIIKDLRQLREQKGADVKEHELIDKKKRLDDHYEAKSIKQNVQKQKYDKIVAGDEVKVLSYGQKGEVLEIVNDEEAIVQMGIIKMKLPIEDLEKKQKEKVKPTKMVTRQNRQTIKTELDLRGYRYEDALIELDQYLDQAVLSNYEQVYIIHGKGTGALQKGVQQHLKKHKSVSDFRGGMPSEGGFGVTVATLK
>CP031131.1|AXG00574.1|1124962_1125277_+|thiol-reductase-thioredoxin
MAIVKVTDADFDSKVESGVQLVDFWATWCGPCKMIAPVLEELAADYEGKADILKLDVDENPSTAAKYEVMSIPTLIVFKDGQPVDKVVGFQPKENLAEVLDKHL
>CP031131.1|AXG00575.1|1125339_1125435_-|hypothetical-protein
MLDYHLTFIDLLIPPFSSRKQYDDLSFNFLY
>CP031131.1|AXG00576.1|1125600_1127382_+|excinuclease-ABC-subunit-C
MEDYKQRIKNKLNVVPMEPGCYLMKDRNDQVIYVGKAKKLRNRLRSYFTGAHDAKTTRLVGEIRRFEFIVTSSETESLLLELNLIKQYQPRYNILLKDDKSYPFIKITKEKYPRLLVTRTVKQGTGKYFGPYPNAYSAQETKKLLDRIYPYRKCDKMPDKLCLYYHIGQCLGPCVYDVDLSKYAQMTKEITDFLNGEDKTILKSLEERMLTASESLDFERAKEYRDLIQHIQNLTNKQKIMSSDKTIRDVFGYCVDKGWMCIQVFFIRQGNMIKRDTTMIPLQQTEEEEFYTFIGQFYSLNQHILPKEVHVPRNLDKEMIQSVVDTKIVQPARGPKKDMVDLAAHNAKVSLNNKFELISRDESRTIKAIEELGTQMGIQTPIRIEAFDNSNIQGVDPVSAMVTFVDGKPDKKNYRKYKIKTVKGPDDYKSMREVVRRRYSRVLNEGLPLPDLIIVDGGKGHMNGVIDVLQNELGLDIPVAGLQKNDKHQTSELLYGASAEIVPLKKNSQAFYLLHRIQDEVHRFAITFHRQTRQKTGLKSILDDIDGIGNKRKTLLLRSFGSIKKMKEATLEDFKNIGIPENVAKNLHEQLHK
>CP031131.1|AXG00577.1|1127705_1128320_+|succinate-dehydrogenase
MAQSKNEFYLRRIHSLLGIIPIGAFLVVHLLVNHQATQGAEAFNKASNFMESLPFLIIVEFLFIYIPLLYHGLFGIHIAFTAKENVGHYSIFRNWMFFFQRVSGILTFIFIGIHLWQTRLQKAFYGKEVNYDLMHETLQHPGWAIFYIICIIAVVFHFANGLWSFLVTWGGLQSPKSQRVFTWVSLIVFLVISYIGVTAIIAFM
>CP031131.1|AXG00578.1|1128371_1130138_+|succinate-dehydrogenase-flavoprotein-subunit
MAEKHLIVVGGGLAGLMSTIKAAEKGAHVDLFSVVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTVYGGDFLANQPPVKAMTEAAPKIIHLLDRMGVMFNRTNEGLLDFRRFGGTLHHRTAYAGATTGQQLLYALDEQVRAFEVDGLVTKYEGWEFLGIVKGDDDSARGIVAQNMTTAEIETFGSDAVIMATGGPGIIFGKTTNSMINTGSAASIVYQQGAIYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRIWTYKDGKPWYFLEEKYPDYGNLVPRDIATREIFDVCINQKLGINGENMVYLDLSHKDPHELDVKLGGIIEIYEKFTGDDPRKVPMKIFPAVHYSMGGLYVDYDQMTNIKGLFAAGECDFSQHGGNRLGANSLLSAIYGGTVAGPNAIDYISNIDRSYTDMDESIFEKRKAEEQERFDKLLAMRGTENAYKLHRELGEIMTANVTVVRENEKLLETDKKIVELMKRYEDIDMEDTQTWSNQAVFFTRQLWNMLVLARVITIGAYNRNESRGAHYKPEFPERNDEEWLKTTMASFQGAFEKPQFTYDDVDVSLIPPRKRDYTSKSKGGKK
>CP031131.1|AXG00579.1|1130137_1130953_+|succinate-dehydrogenase-iron-sulfur-subunit
MTEQSVKNTPQHETQSKPKQKTVKLIIKRQDTSDSKPYEETFEIPYRENLNVIACLMEIRRNPVNIKGEKTTPVVWDMNCLEEVCGACSMVINGRARQSCSAIVDQLEQPIRLEPMNTFPVIRDLQVDRSRMFDNLKRMKAWIPIDGTYDLGPGPRMPEKKRQTAYELSKCMTCGVCLEVCPNVTENNKFVGAQAISQVRLFNLHPTGSMTKDERLNALMGTGGLQQCGNSQNCVNACPKGIPLTTSIAAMNRETTFHMFKSFFGSDHEVE

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Crispr_ID: CP031131_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP031131_4

1899144-1899225

Orphan

Consensus_repeat	Method
TGCAAGTTGGCGGGGCCACAACATAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP031131_4

>merge|CP031131|4|1899144-1899225|CRISPRCasFinder
TGCAAGTTGGCGGGGCCACAACATAGTGGAATTGGATTCCCAATTTCTACAGACATTGCAAGTTGGCGAGGCCACAACATAG

>CP031131|4|4|1899144-1899225|CRISPRCasFinder
TGCAAGTTGGCGGGGCCACAACATAG	TGGAATTGGATTCCCAATTTCTACAGACAT
TGCAAGTTGGCGAGGCCACAACATAG

Protein	Signature genes	Signature genes Name	Protein_function
CP031131.1\|AXG01281.1\|1901086_1902214_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	unknown	unknown	gnl\|CDD\|272993
CP031131.1\|AXG01275.1\|1896867_1898253_-\|class-II-fumarate-hydratase	unknown	unknown	gnl\|CDD\|234779
CP031131.1\|AXG01269.1\|1891137_1891482_-\|YlbF/YmcA-family-competence-regulator	unknown	unknown	gnl\|CDD\|237467
CP031131.1\|AXG01283.1\|1903078_1904536_-\|ABC-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|223836
CP031131.1\|AXG01276.1\|1898448_1898844_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01284.1\|1904793_1905855_-\|PTS-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|226167
CP031131.1\|AXG01287.1\|1916299_1916755_-\|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl\|CDD\|224146
CP031131.1\|AXG01268.1\|1890658_1890865_+\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01279.1\|1899854_1900454_-\|glucosamine-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|223440
CP031131.1\|AXG01267.1\|1890546_1890645_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01286.1\|1915343_1916294_-\|hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240632
CP031131.1\|AXG01271.1\|1892853_1893318_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224393
CP031131.1\|AXG01282.1\|1902363_1903092_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
CP031131.1\|AXG01272.1\|1893673_1894297_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107
CP031131.1\|AXG01278.1\|1899677_1899830_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01273.1\|1894318_1895431_-\|GAF-domain-containing-protein	unknown	unknown	gnl\|CDD\|226951
CP031131.1\|AXG01270.1\|1891550_1892675_-\|DUF445-family-protein	unknown	unknown	gnl\|CDD\|226834
CP031131.1\|AXG01285.1\|1914800_1915247_-\|transcriptional-repressor	unknown	unknown	gnl\|CDD\|223806
CP031131.1\|AXG01274.1\|1895593_1896415_+\|RluA-family-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|223638
CP031131.1\|AXG01280.1\|1900611_1901082_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	unknown	unknown	gnl\|CDD\|223297

Protein	Function_ID	Function_description	E-value
CP031131.1\|AXG01281.1\|1901086_1902214_-\|tRNA-epoxyqueuosine(34)-reductase-QueG	gnl\|CDD\|272993	TIGR00276, iron-sulfur_cluster-binding_protein, epoxyqueuosine reductase. This model was rebuilt to exclude archaeal homologs, now that there is new information that bacterial members are epoxyqueuosine reductase, QueG, involved in queuosine biosynthesis for tRNA maturation. [Protein synthesis, tRNA and rRNA base modification].	2.34756e-178
CP031131.1\|AXG01275.1\|1896867_1898253_-\|class-II-fumarate-hydratase	gnl\|CDD\|234779	PRK00485, fumC, fumarate hydratase; Reviewed.	0
CP031131.1\|AXG01280.1\|1900611_1901082_-\|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL	gnl\|CDD\|223297	COG0219, CspR, Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis].	1.70324e-88
CP031131.1\|AXG01283.1\|1903078_1904536_-\|ABC-transporter-permease-subunit	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	2.14709e-98
CP031131.1\|AXG01284.1\|1904793_1905855_-\|PTS-transporter-subunit-IIC	gnl\|CDD\|226167	COG3641, PfoR, Predicted membrane protein, putative toxin regulator [General function prediction only].	2.31644e-122
CP031131.1\|AXG01287.1\|1916299_1916755_-\|thioredoxin-dependent-thiol-peroxidase	gnl\|CDD\|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	1.44283e-68
CP031131.1\|AXG01279.1\|1899854_1900454_-\|glucosamine-6-phosphate-isomerase	gnl\|CDD\|223440	COG0363, NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism].	6.38527e-11
CP031131.1\|AXG01286.1\|1915343_1916294_-\|hydroxyacid-dehydrogenase	gnl\|CDD\|240632	cd12155, PGDH_1, Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family. Phosphoglycerate Dehydrogenase (PGDH) catalyzes the NAD-dependent conversion of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first step in serine biosynthesis. Over-expression of PGDH has been implicated as supporting proliferation of certain breast cancers, while PGDH deficiency is linked to defects in mammalian central nervous system development. PGDH is a member of the 2-hydroxyacid dehydrogenase family, enzymes that catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann-fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	3.25267e-136
CP031131.1\|AXG01271.1\|1892853_1893318_-\|transcriptional-regulator	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	5.18868e-15
CP031131.1\|AXG01282.1\|1902363_1903092_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	2.22702e-152
CP031131.1\|AXG01272.1\|1893673_1894297_-\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.11819e-78
CP031131.1\|AXG01273.1\|1894318_1895431_-\|GAF-domain-containing-protein	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	7.65897e-57
CP031131.1\|AXG01270.1\|1891550_1892675_-\|DUF445-family-protein	gnl\|CDD\|226834	COG4399, COG4399, Uncharacterized protein conserved in bacteria [Function unknown].	4.6883e-165
CP031131.1\|AXG01285.1\|1914800_1915247_-\|transcriptional-repressor	gnl\|CDD\|223806	COG0735, Fur, Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism].	6.09298e-56
CP031131.1\|AXG01274.1\|1895593_1896415_+\|RluA-family-pseudouridine-synthase	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	3.35529e-78
CP031131.1\|AXG01269.1\|1891137_1891482_-\|YlbF/YmcA-family-competence-regulator	gnl\|CDD\|237467	PRK13676, PRK13676, YlbF/YmcA family competence regulator.	1.19759e-37

>CP031131.1|AXG01276.1|1898448_1898844_-|hypothetical-protein
MLGKYWIQLLIATVIISLISIKAFPLAIGALYLPVIFKVIKLQLNLSKGLIDDVNAQTFIKSNQSGIVISVICCLLITGILYYTLDGFYASLTGVLGTLVALNPYTTIVSAVLYILTAIATVEATKTKYRN
>CP031131.1|AXG01275.1|1896867_1898253_-|class-II-fumarate-hydratase
MSVRIEHDTFGEIEVPADKYWGAQTERSKRNFPVGKERMPIEVVYGFAQLKRAAALANFDLGKLSEAKKDAIVYACDQILSGELDEHFPLVVWQTGSGTQSNMNVNEVVSYVANMYLKDHQSDESIHPNDDVNKSQSSNDTFPTAMHVALYQEVETKLEPALKLLRNTLKEKEDKFDSIIKIGRTHLQDATPIKLGQEISGWRYMLDRCEIMLSESKKHILNLAIGGTAVGTGINAHPEFGDKVAHYISENTGYPFVSSENKFHALTAHDEVVQLHGTLKALAGDLMKIANDVRWLASGPRAGLAEISIPENEPGSSIMPGKVNPTQCEMLTMVAVQVMGNDTVVGFASSQGNFELNVYKPVIMHNTLQSIYLLADGMETFNNNCAVGIEPIEENIDNYLNQSLMLVTALNPHIGYEKAAQIAKKAHKEGLTLKESAIQTGYVTEEQFEAWIKPEDMVDPH
>CP031131.1|AXG01274.1|1895593_1896415_+|RluA-family-pseudouridine-synthase
MKFKIPENFNDLSLRDIFQQLKVPKKDLHHLNMSKDITINDKPARLMDKVHTGDDVFVPTIDEKSNYVPSYRYAQIKYEDDDMAIVMKPKGVKTHPNDLKESNTLMNHVIYTIDSDYVEPIHRLDQETVGLLIVAKNPLMKKILDRMLEDNDITRIYKANVKALLPLKPQTIDMPIGKDKFHSNKRRVSPTGQRAITHILTSKMIKEAVCQLEIKLDTGRTHQIRVHLAEIGHPVIGDPLYGDSTLRQLELESYKIEFVHPLTKEVISVSLDD
>CP031131.1|AXG01273.1|1894318_1895431_-|GAF-domain-containing-protein
MEQRTRLALLKEIAEFLNEETEMYSMTQGALKYLIEGSNFTTGWIFFINSVGEHELVSHVALPQSLTADHCHYIKDGSCWCVKAFNQRRLMKASNIVNCSRINLASKAFPSQNDNITHHATVPLKSGQEQFGILNVASPNTEIYSDEDLELLESVAFQLGSAIKRIYLTDREKEAAKINERNRLARDLHDSVNQMLFSVKLTAHAAYGMSNESIAKQAFKTIEETSQNAVNEMRALIWQLKPVGLEQGLIHALTAYSKLMHIQLNVNVEGLIDLSNEIEENIYRALQECINNVKKHADTNKMDLTLKQMNDILYIDVIDYGQGFEIDNVQIASSHGINNIKQRVKLLRGRVTFHSQPTKGTQIQFTIPIK
>CP031131.1|AXG01272.1|1893673_1894297_-|DNA-binding-response-regulator
MNKVILVDDHYIVRQGLRFLLSTIENIEVLQDFADGETFLEYLKEHEHPDIVLLDLVMPGMNGIEITEYIKAHYPDIKVLVLTSYVDDEHVISAINKGADGYEMKDVEPQQLIETIRRVMNGEKMIHPKAQDVFETVSQKPHYTNKLSKREIEVLREMVKGKTNKEIAETLFVSEKTIKTHVSHIFSKLQVSDRTQAAIYAMENKLI
>CP031131.1|AXG01271.1|1892853_1893318_-|transcriptional-regulator
MDRQSFTDLIQTKFKMVRIEAGYTQDTMAQTIGLSKKTLVQIEKERVLPNWTTCISICALFRDSEVLNSTFGCDPLEIVQTISRNHCAYPNHAPTSDIYWNNIETRNGYILQSNKVSNIYRVLNPDNQPIFGTSKMREAETYFNRNAKEELVHI
>CP031131.1|AXG01270.1|1891550_1892675_-|DUF445-family-protein
MNALFIIIFMIVVGAIIGGITNVIAIRMLFHPFKPYYIFKFRVPFTPGLIPKRREEIATKIGQVIEEHLLTETLINEKLKSEQSQQAIESMIQQQLQKLTKDQLSIKQITSQIDIDLEQVLQTNGNQYIESQLNNYYTKHQNQTIASLLPNQLVTFLDQHVDNATDLLCDRARNYLSSAKGTQDINDMLDTFFNEKGKLIGMLQMFMTKESIADRIQQELIRLTSHPKARTIVTSLITNEYQTFKDKPLNELLDASQFNEIAENLSVYITTYASKQANKPVVTLMPQFVDYLEGQLSSKLANLIIEQLSIHLSTIMKKVDLRGLIEEQINTFDLDYIEKLIIEIANKELKLIMSLGFILGGIIGFFQGLVAIFV
>CP031131.1|AXG01269.1|1891137_1891482_-|YlbF/YmcA-family-competence-regulator
MAVNLYDYANQLEQALRESEEYKAIKEAFANVKANEESKKLFDEFRETQINFQQKQMQGEEIAEEDLQKAQEQAQAIEKDENISALMNAEQKMSQVFQEINQIIVKPLDEIYAD
>CP031131.1|AXG01268.1|1890658_1890865_+|hypothetical-protein
MITLLDLLGSNDQLETKCQNYHCTKYAKHFQAVLNESLKVKRFSISPIHDRTNSIMLKTLHFKMQKGS
>CP031131.1|AXG01267.1|1890546_1890645_-|hypothetical-protein
MSVGSLAVLTITEIAFPTEIFEKNQRTLQIKF
>CP031131.1|AXG01278.1|1899677_1899830_-|hypothetical-protein
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
>CP031131.1|AXG01279.1|1899854_1900454_-|glucosamine-6-phosphate-isomerase
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEGLGVPAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGKTSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
>CP031131.1|AXG01280.1|1900611_1901082_-|tRNA-(uridine(34)/cytosine(34)/5--carboxymethylaminomethyluridine(34)-2'-O)--methyltransferase-TrmL
MTNHIVLYQPEIPANTGNIARTCAGTNTHLHLIKPLGFRTDDKMLKRAGLDYWEFVNITYHDSIEAFFEATNGEYYLLTKFGKKTYSDFDFSNHDKDFYFIFGKETTGLPDWVKEKYQDTALRIPMSEHIRSLNLSNTAALLIYEALRQQDFPGLN
>CP031131.1|AXG01281.1|1901086_1902214_-|tRNA-epoxyqueuosine(34)-reductase-QueG
MDTKQLKQDIIDYAYTIGIDSIGFTTADRFDELKQKLEAYHANGYASGFEESDIALRTEPKLSLPTARSIIAIAVGYPNKLKGAPKSVRGDRRGLFARASWGQDYHTIMRKRLDMLASFIESKVPDVEIKSMVDTGVLSDRAVAERAGLGFVGRNGFVINPKLGTWTYLGEMLVSIPFEPDDPLLDSCGDCTICVDRCPTSALVGNGQLNSQKCISFLTQTKGYMPDQYRYKIGNRLYGCDTCQQVCPKNRGINTEQDDIILEPEILKPRLVPLLRMSNKEFKQTYGHLAGAWRGKKPIQRNAILALAHFNEVDAIPELKKVAITDERPMIRATAYWAIGQILGEEARDFINANYDQEDAEVQNEMIKGLDTRRE
>CP031131.1|AXG01282.1|1902363_1903092_-|amino-acid-ABC-transporter-ATP-binding-protein
MPVIKINNLNKVFGDNEVLKDINLEINQGEVVAIIGPSGSGKSTLLRCMNLLEVPTKGQVIFEGNDLTEKGTQVDKLRQKMGMVFQNFNLFPHKKVVDNIILAPKLLKKDNNDELHKEALSLLDKVGLKEKADVYPNQLSGGQKQRVAIARALAMHPDVILFDEPTSALDPEVVGDVLKVMKDLAKEGMTMVVVTHEMGFAKDVSDKVIFMADGVVVESGTPVEIFEQPQHERTQNFLARVL
>CP031131.1|AXG01283.1|1903078_1904536_-|ABC-transporter-permease-subunit
MKCLIRFILVLGLLISSAMVYINPTAHAEQDQTWEKIKERGELRVGLSADYAPMEFEHTVNGKTEYAGVDIDLAKKIAKDNNLKLKIVNMSFDSLLGALKTGKIDIIISGMTSTPERKKQVDFSDSYMMTKNIMLVKKDKVNEYKDIKDFNNKKVGAQKGTEQEKIAQTEIENASITSLSRLPDVILALKSGKVEGAVVEKPVAEAYLKQNPKLGISNVKFNEEEKDTVIAVPKDSPKLLSQINKTIKEVKDKGLIDKYMTNAANAMNDDSGFISKYGSFFLKGIKITILISLIGVALGSILGAFVALMKLSKIKIISWIASIYIEILRGTPMLVQVFIVFFGITAALGLDISALVCGTIALVINSSAYIAEIIRAGINAVDKGQMEAARSLGLNYRQTMKSVIMPQAIKNILPALGNEFVTLIKESSIVSTIGVGEIMFNAQVVQGISFDPFTPLIVAAALYFVLTFVLTRIMNMIEGRLNASD
>CP031131.1|AXG01284.1|1904793_1905855_-|PTS-transporter-subunit-IIC
MSNANNADNKQFFSKILNSIGAGVVIALVPNALLGEVLKIFKSGNEILELTYQLVILIQSFMAFIIGVLAAHQFKFNGAGAAIVGTSAMIGSGAVVYSNNSFMLKGIGDIINTSLVVIIACLIYMVLQNKLGSFELIILPVLVPIVSGGIGLITLPYIRKITQAIGNVIHSFTDLNPLLMSILISVAFSLLMVTPISLVAIATAISLNGLGSGAANLGIVAACVTFLFGSLRVNSIGVNAVLLIGAAKMMIPVYLKNLIISIPLTINGIITGIIAYVLQVKGTPLSAGFGYTGLVGPINAFNRMSGDPTMNIILLALGYFVIPFVSAFIVHELCKKFIPIYSNDIYKFEVPKQ
>CP031131.1|AXG01285.1|1914800_1915247_-|transcriptional-repressor
MSVEIESIEHELEESIASLRQAGVRITPQRQAILRYLISSHTHPTADEIYQALSPDFPNISVATIYNNLRVFKDIGIVKELTYGDSSSRFDFNTHNHYHIICEQCGKIVDFQYPQLNEIERLAQHMTDFDVTHHRMEIYGVCKECQDK
>CP031131.1|AXG01286.1|1915343_1916294_-|hydroxyacid-dehydrogenase
MKVVGLNRMREVETELQQRFSDLDFKFYKKASEIPESDLADLDILVGYDGGINEAFLQRCPNLKWIAWFATGVNTLPLDYIADHGILLTNGKGVQAKQLSEYILAFILDDYKKMKLSYDNQRQHIYDSKITGKRLSGQTVLFLGTGAIATRTAKLAKAFNMNLIGLSKSGQNKDEFDEIYTIESLESTLPNADIIINALPETQETIHLLKKKHFELMKDEALFINIGRGSIVKEAVLIEVLKSKVIRHAYLDVFENEPLKPNHELYELENVTITAHITGNDYEAKYDLLDIFKNNLVNFLNKNGLIENEVDAKKGY
>CP031131.1|AXG01287.1|1916299_1916755_-|thioredoxin-dependent-thiol-peroxidase
MLQKGEQFPIFKLENQDGTVITNDTLKGKKAIIYFYPRDNTPTCTTEACDFRDNLEMFNDLDVAVYGISGDSKKKHQNFIEKHGLNFDLLVDEDFKLAKETGVYQLKKSFGKESMGIVRTTFIIDEQGKVLDVIEKVKVKTQIEELKNILG

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Crispr_ID: CP031131_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP031131_5

1940843-1940923

Orphan

Consensus_repeat	Method
TCTATGTTGGGGCCCCGCCAACCTG	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of CP031131_5

>merge|CP031131|5|1940843-1940923|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACCTGCACATTATCGTAAGCTGACTTTTCGTCAGCTTCTGTGTTGGGGCCCCGCCAACCTG

>CP031131|5|5|1940843-1940923|CRISPRCasFinder
TCTATGTTGGGGCCCCGCCAACCTG	CACATTATCGTAAGCTGACTTTTCGTCAGCT
TCTGTGTTGGGGCCCCGCCAACCTG

Protein	Signature genes	Signature genes Name	Protein_function
CP031131.1\|AXG01318.1\|1946474_1947029_+\|DNA-polymerase-III-subunit-epsilon	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|99834
CP031131.1\|AXG01309.1\|1938576_1939278_-\|transporter	unknown	unknown	gnl\|CDD\|227100
CP031131.1\|AXG01304.1\|1934564_1935029_+\|protein-tyrosine-phosphatase	unknown	unknown	gnl\|CDD\|319971
CP031131.1\|AXG01310.1\|1939302_1939689_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01316.1\|1945584_1946085_+\|non-heme-ferritin	unknown	unknown	gnl\|CDD\|224445
CP031131.1\|AXG01307.1\|1936917_1937547_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|225107
CP031131.1\|AXG01319.1\|1947095_1948166_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
CP031131.1\|AXG01308.1\|1937536_1938580_-\|two-component-sensor-histidine-kinase	unknown	unknown	gnl\|CDD\|226951
CP031131.1\|AXG01305.1\|1935035_1935311_+\|YtxH-domain-containing-protein	unknown	unknown	unknown
CP031131.1\|AXG01303.1\|1932958_1934215_-\|aminopeptidase	unknown	unknown	gnl\|CDD\|376723
CP031131.1\|AXG01312.1\|1941191_1942178_+\|aromatic-acid-exporter-family-protein	unknown	unknown	gnl\|CDD\|226614
CP031131.1\|AXG01317.1\|1946166_1946259_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01313.1\|1943050_1943161_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01306.1\|1935588_1936806_+\|YihY/virulence-factor-BrkB-family-protein	unknown	unknown	gnl\|CDD\|224214
CP031131.1\|AXG01314.1\|1943246_1943978_-\|glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|225974
CP031131.1\|AXG01320.1\|1948412_1948943_-\|DUF3267-domain-containing-protein	unknown	unknown	gnl\|CDD\|378690
CP031131.1\|AXG01315.1\|1943979_1945293_-\|Mur-ligase-family-protein	unknown	unknown	gnl\|CDD\|223840
CP031131.1\|AXG01311.1\|1939905_1940664_-\|methionine-aminopeptidase	unknown	unknown	gnl\|CDD\|235576
CP031131.1\|AXG02199.1\|1942608_1943022_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG02198.1\|1934217_1934418_-\|DUF1128-family-protein	unknown	unknown	gnl\|CDD\|227177

Protein	Function_ID	Function_description	E-value
CP031131.1\|AXG01318.1\|1946474_1947029_+\|DNA-polymerase-III-subunit-epsilon	gnl\|CDD\|99834	cd06130, DNA_pol_III_epsilon_like, an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III. This subfamily is composed of uncharacterized bacterial proteins with similarity to the epsilon subunit of DNA polymerase III (Pol III), a multisubunit polymerase which is the main DNA replicating enzyme in bacteria, functioning as the chromosomal replicase. The Pol III holoenzyme is a complex of ten different subunits, three of which (alpha, epsilon, and theta) compose the catalytic core. The Pol III epsilon subunit, encoded by the dnaQ gene, is a DEDDh-type 3'-5' exonuclease which is responsible for the proofreading activity of the polymerase, increasing the fidelity of DNA synthesis. It contains three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. The epsilon subunit of Pol III also functions as a stabilizer of the holoenzyme complex.	4.39188e-75
CP031131.1\|AXG01304.1\|1934564_1935029_+\|protein-tyrosine-phosphatase	gnl\|CDD\|319971	cd16343, LMWPTP, Low molecular weight protein tyrosine phosphatase. Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.	3.39151e-65
CP031131.1\|AXG01316.1\|1945584_1946085_+\|non-heme-ferritin	gnl\|CDD\|224445	COG1528, Ftn, Ferritin-like protein [Inorganic ion transport and metabolism].	4.6035e-74
CP031131.1\|AXG01307.1\|1936917_1937547_-\|DNA-binding-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	2.91794e-79
CP031131.1\|AXG01319.1\|1947095_1948166_-\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
CP031131.1\|AXG01308.1\|1937536_1938580_-\|two-component-sensor-histidine-kinase	gnl\|CDD\|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	6.78722e-72
CP031131.1\|AXG01309.1\|1938576_1939278_-\|transporter	gnl\|CDD\|227100	COG4758, COG4758, Predicted membrane protein [Function unknown].	9.42019e-79
CP031131.1\|AXG01303.1\|1932958_1934215_-\|aminopeptidase	gnl\|CDD\|376723	pfam02073, Peptidase_M29, Thermophilic metalloprotease (M29).	0
CP031131.1\|AXG01312.1\|1941191_1942178_+\|aromatic-acid-exporter-family-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	5.31001e-76
CP031131.1\|AXG01306.1\|1935588_1936806_+\|YihY/virulence-factor-BrkB-family-protein	gnl\|CDD\|224214	COG1295, Rbn, Ribonuclease BN family enzyme [Replication, recombination, and repair].	3.59491e-85
CP031131.1\|AXG02198.1\|1934217_1934418_-\|DUF1128-family-protein	gnl\|CDD\|227177	COG4840, COG4840, Uncharacterized protein conserved in bacteria [Function unknown].	9.24488e-25
CP031131.1\|AXG01320.1\|1948412_1948943_-\|DUF3267-domain-containing-protein	gnl\|CDD\|378690	pfam11667, DUF3267, Putative zincin peptidase. This family of proteins has a conserved HEXXH motif, suggesting the members are putative peptidases of zincin fold.	1.4991e-11
CP031131.1\|AXG01311.1\|1939905_1940664_-\|methionine-aminopeptidase	gnl\|CDD\|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	1.9498e-126
CP031131.1\|AXG01315.1\|1943979_1945293_-\|Mur-ligase-family-protein	gnl\|CDD\|223840	COG0769, MurE, UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane].	3.37755e-99
CP031131.1\|AXG01314.1\|1943246_1943978_-\|glutamine-amidotransferase	gnl\|CDD\|225974	COG3442, COG3442, Predicted glutamine amidotransferase [General function prediction only].	2.14444e-120

>CP031131.1|AXG01311.1|1939905_1940664_-|methionine-aminopeptidase
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE
>CP031131.1|AXG01310.1|1939302_1939689_-|hypothetical-protein
MNYVERYIEQFLRATVRNNIKHYLLMLDEKMKNLDDYMRYLITKKEQLSKLIDSLMLTLENKYIDIAEAFQIQCAREINNQEIENIKSELNKVEAYYAQIETQIQQTSTEKIATEKTSYLINYMNAVA
>CP031131.1|AXG01309.1|1938576_1939278_-|transporter
MTHKYISTQMLIIFTALMIIANFYYIFFEKIGFLLVLLLGCVLVYVGYLYFHKIRGLLAFWIGALLIAFTLLSNKYTIIILFVFLLLLIVRYLIHKFKPKKVVATDEVMTSPSFIKQKWFGEQRTPVYVYKWEDVQIQHGIGDLHIDLTKAANIKENNTIVVRHILGKVQVILPVNYNINLHVAAFYGSTYVNEKSYKVENNNIHIEEMMKPDNYTVNIYVSTFIGDVEVIYR
>CP031131.1|AXG01308.1|1937536_1938580_-|two-component-sensor-histidine-kinase
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKTQIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVSQQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEIQDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGATFHIVSLPDSGTRIEVKAPLNKEDSYDD
>CP031131.1|AXG01307.1|1936917_1937547_-|DNA-binding-response-regulator
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVLMLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIAKGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ
>CP031131.1|AXG01306.1|1935588_1936806_+|YihY/virulence-factor-BrkB-family-protein
MSKKDHSSSKYLNSVKEAQEESKKKNKSNPKIDVDRTYIEPQQFQSKKPKKDDQVFFLSRLNKPAKYKKDSNFLSYLIYRIGKDDASGLAAQMTYHFVLAMFPMLLFLLTLLPFFNIKQSQITNMLSNAPAETSTLIKSVIGDITQNSSGGLLSIGLILAIWSASNGMTAIMNSFNVAYDVEDSRNGIVLKLLSVVFTVVMGVVFVVALALPTLGSVISHFLFGPLGFDEQVKWIFNLIRIVLPIIIIFIVFIVLYSVAPNVKTKLKSVLPGAVFTSIIWLAGSFGFGWYISNFGNYSKTYGSIAGIIILLLWLYITSFIIIVGAEINAIIHQRSVIKGKTPEEAALEHDDNNKNHYNENTRYEYDEDSNATHQRTYHVDEHPSDTYPEDDKNIKDKIVDKLKKD
>CP031131.1|AXG01305.1|1935035_1935311_+|YtxH-domain-containing-protein
MENKFVPGILIGAVIGGAISLADKSTRQALVQSVKDAKNGNRTRKPSKVSKIKDEVLYWKDVVEEIRRNNPELERSLKDAKETFVNRKNQR
>CP031131.1|AXG01304.1|1934564_1935029_+|protein-tyrosine-phosphatase
MVDVAFVCLGNICRSPMAEAIMRQRLKDRNIHDIKVHSRGTGSWNLGEPPHEGTQKILNKHNIPFDGMISELFEATDDFDYIVAMDQSNVDNIKSINPNLKGQLFKLLEFSNMEESDVPDPYYTNNFEGVYDMVLSSCDNLIDYIVKDANLKEG
>CP031131.1|AXG02198.1|1934217_1934418_-|DUF1128-family-protein
MTNEEKVLAIREKLNIVNQGLLDPEKYKNANEEELTDIYDFVQSRERLSPSEVTAIADALGQLRHD
>CP031131.1|AXG01303.1|1932958_1934215_-|aminopeptidase
MGILTNYKEKLQQYAELLVKVGMNVQPKQPVFIRSSVETLELTHLIVEEAYHCGASDVRVVYSDPTLKRLKFENESVEHFANHELKSYDVEARMDYVKRGAANLALISEDPDLMDGIDSQKLQAFQQQNARAFKGYMESVQKNQFPWVVAAFPSKAWAKRVYPELSVEEAYIKFIDEVFDIVRIDGNDPVENWRQHIANLSVYAQKLQQKNYHALHYVSEGTDLTVGLAKNHIWEDATSYVNGKEQAFIANIPTEEVFTAPDRNRVDGYVTNKLPLSYNGTIIDQFKLMFKDGEIIDFSAEKGEAVLKDLINTDEGSRRLGEVALVPDDSPISNRNTIFYNTLFDENAACHLAIGSAYAFNIQGGTEMTVEEKIASGLNDSNVHVDFMIGSSDLTIYGIFEDGSKELVFENGNWASTF
>CP031131.1|AXG01312.1|1941191_1942178_+|aromatic-acid-exporter-family-protein
MNDQWYKHLIGARTIKTGIAIFLTAVFCMALDLTPIYAILTAVVTIEPTAKASLIKGYRRLPATVIGAGFAVLFTYLFGDQSPFTYALSATFTILFCTKLKLQVGTNVAVLTSLAMIPGIHDAYIFNFLSRTLTAIIGLVTSGLINFMVFPPKYYGQVEEKLSKTDALMYKLFYNRCQELILSRLQSDKSEKAYKNIFNLNNQVETLISYQRDELSYHKKKECDWKLLNQLTKRAYTNRLFITHLSNIIYLPKNTRVNFSGDEKMALLKISSSIKDIFYDGSFKREDDSVETLRSTIKALEISGENQIKSHLLYEVLMIYRLLDSRYA
>CP031131.1|AXG02199.1|1942608_1943022_-|hypothetical-protein
MKPTKVILRDASYLHSKTSITFILKDVVIEEDNKIYYFDTSATFEDQEVKFEFALFDSDMDNLKHMDYDNPVTEIYFIEPDLHFTIIDFNQELLCIYIDFDSGLRHSNMATESGISLRINVAKSDFTKFINELASLY
>CP031131.1|AXG01313.1|1943050_1943161_-|hypothetical-protein
MDGNNQIDVCFFVLVNNYYTMSIYPRIINSNGDYAT
>CP031131.1|AXG01314.1|1943246_1943978_-|glutamine-amidotransferase
MHELTIYHFMSDKLNLYSDIGNIIALRQRAKKRNIKVNVVEINETEGITFDECDIFFIGGGSDREQALATKELSKIKTPLKEAIEDGMPGLTICGGYQFLGKKYITPDGTELEGLGILDFYTESKTNRLTGDIIIESDTFGTIVGFENHGGRTFHDFGTLGHVTFGYGNNDEDKKEGIHYKNLLGTYLHGPILPKNYEITDYLLEKACERKGIPFEPKEIDNEAEIQAKQVLIDRANRQKKSR
>CP031131.1|AXG01315.1|1943979_1945293_-|Mur-ligase-family-protein
MRQWTAIHLAKLARKASRAVGKRGTDLPGQIARKVDTDILRKLAEQVDDIVFISGTNGKTTTSNLIGHTLKANNIQIIHNNEGANMAAGITSAFIMQSTPKTKIAVIEIDEGSIPRVLKEVTPSMMVFTNFFRDQMDRFGEIDIMVNNIAETISNKGIKLLLNADDPFVSRLKIASDTIVYYGMKAHAHEFEQSTMNESRYCPNCGRLLQYDYIHYNQIGHYHCQCGFKREQAKYEISSFDVAPFLHLNINDEKYDMKIAGDFNAYNALAAYSVLRELGLNEQTIKNGFETYTSDNGRMQYFKKERKEAMINLAKNPAGMNASLSVGEQLEGEKVYVISLNDNAADGRDTSWIYDADFEKLSKQQIEAIIVTGTRAEELQLRLKLAEVEVPIIVERDIYKATAKTMDYKGFTVAIPNYTSLAPMLEQLNRSFEGGQS
>CP031131.1|AXG01316.1|1945584_1946085_+|non-heme-ferritin
MLSKNLLEALNDQMNHEYFAAHAYMAMAAYCDKESYEGFANFFIQQAKEERFHGQKIYNYINDRGAHAEFRAVSAPKIDFSSILETFKDSLSQEQEVTRRFYNLSEIARQDKDYATISFLNWFLDEQVEEESMFETHINYLTRIGDDSNALYLYEKELGARTFDEE
>CP031131.1|AXG01317.1|1946166_1946259_-|hypothetical-protein
MTKNTIISLENEKTQINDSENESSDLRKAK
>CP031131.1|AXG01318.1|1946474_1947029_+|DNA-polymerase-III-subunit-epsilon
MIQDAFVALDFETANGKRTSICSVGMVKVIDSQITETFHTLVNPQDYFSQQNIKVHGIQPEDVENAPTFDYVFPYMMQFIADLPVVAHNAAFDMNVLHQSIQNIGLPTPNLTYFCSYQLAKRTVDSYRYGLKHMMEFYQLDFHGHHDALNDAKACAMITFRLLKNYENLTYVTNIYGKNLKDKG
>CP031131.1|AXG01319.1|1947095_1948166_-|DNA-polymerase-IV
MTERRIIHIDMDYFFAQVEMRDNPKLKGKPVIVGGKASSRGVVSTASYEARKYGVYSAMPMSQAHKLCPNGYFVTSNFGAYRETSAQIMSIFRSYTDKVEPMSLDEAYLDITELVRPDLPASKIAQYIRKDILEKTHLTASAGVSYNKFLAKLASGMNKPDGMTVIDYQNVHDILMTLDIGEFPGVGKASKKVMHDNGIFNGRDLYEKTEFELIRLFGKRGRGLYNKARGIDHSEVKSSRVRKSVGTERTFATDVNDDEEILRKVWELSGKTAERLNKLQKSAKTVTVKIKTYQFETLSKQMSLRDSVSSEEDIYNIAYLLYNDLKDPDVPIRLIGVTVGNLEQSTYKNMTIYDFI
>CP031131.1|AXG01320.1|1948412_1948943_-|DUF3267-domain-containing-protein
MHKIDLTTNNFQMRRFIILQLVIALFVILFTYKWALGVTAVVDQNIIINLVYGFAGFIILLILHELIHRALFLLFKKDSKPMFNIKKDRILFQTADACFNKWQFSIIMLSPLILLSTGLLILIKVFGYSSLIFMFSMHTAYCFIDILLVALTISSSFKYVQQDEDSIYLYHQKPTQ

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Crispr_ID: CP031131_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP031131_6

2187672-2187752

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of CP031131_6

>merge|CP031131|6|2187672-2187752|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTACTTTTCAACTTTAGTTGTTAGGGGCTTCT

>CP031131|6|6|2187672-2187752|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTT	ATGCATGCGCTTAGCGCAGGCGCTCCTACTTTT
CAACTTTAGTTGTTAGGGGCTTCT

Protein	Signature genes	Signature genes Name	Protein_function
CP031131.1\|AXG01562.1\|2182804_2183743_-\|class-I-mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|224399
CP031131.1\|AXG01573.1\|2191626_2193432_-\|glutamine--fructose-6-phosphate-aminotransferase	unknown	unknown	gnl\|CDD\|234729
CP031131.1\|AXG01564.1\|2184995_2185316_+\|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
CP031131.1\|AXG01569.1\|2188871_2189030_+\|integrase	unknown	unknown	unknown
CP031131.1\|AXG01566.1\|2186563_2187655_+\|transcriptional-regulator	unknown	unknown	unknown
CP031131.1\|AXG01576.1\|2197829_2198264_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	unknown	unknown	gnl\|CDD\|227014
CP031131.1\|AXG01559.1\|2179628_2180042_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	unknown	unknown	gnl\|CDD\|225556
CP031131.1\|AXG01567.1\|2188087_2188192_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01560.1\|2180498_2181872_-\|EVE-domain-containing-protein	unknown	unknown	gnl\|CDD\|376640
CP031131.1\|AXG01558.1\|2178985_2179429_-\|DNA-starvation/stationary-phase-protection-protein	unknown	unknown	gnl\|CDD\|223854
CP031131.1\|AXG01557.1\|2178154_2178865_+\|purine-nucleoside-phosphorylase	unknown	unknown	gnl\|CDD\|180275
CP031131.1\|AXG01572.1\|2190612_2191395_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224044
CP031131.1\|AXG01565.1\|2185317_2186298_+\|cation-transporter	unknown	unknown	gnl\|CDD\|224151
CP031131.1\|AXG01570.1\|2189465_2189558_+\|erm-Leader-peptide	unknown	unknown	unknown
CP031131.1\|AXG01574.1\|2194112_2195651_+\|PTS-mannitol-transporter-subunit-IICB	unknown	unknown	gnl\|CDD\|225123
CP031131.1\|AXG01571.1\|2189687_2190545_-\|Cof-type-HAD-IIB-family-hydrolase	unknown	unknown	gnl\|CDD\|223635
CP031131.1\|AXG01575.1\|2195685_2197818_+\|PRD-domain-containing-protein	unknown	unknown	gnl\|CDD\|226234
CP031131.1\|AXG01561.1\|2182543_2182774_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01568.1\|2188624_2188807_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01563.1\|2184178_2184844_-\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187554

Protein	Function_ID	Function_description	E-value
CP031131.1\|AXG01562.1\|2182804_2183743_-\|class-I-mannose-6-phosphate-isomerase	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	3.25063e-129
CP031131.1\|AXG01564.1\|2184995_2185316_+\|ArsR-family-transcriptional-regulator	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	2.83702e-17
CP031131.1\|AXG01560.1\|2180498_2181872_-\|EVE-domain-containing-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.86989e-06
CP031131.1\|AXG01576.1\|2197829_2198264_+\|mannitol-specific-phosphotransferase-enzyme-IIA-component	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
CP031131.1\|AXG01571.1\|2189687_2190545_-\|Cof-type-HAD-IIB-family-hydrolase	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	1.99434e-58
CP031131.1\|AXG01573.1\|2191626_2193432_-\|glutamine--fructose-6-phosphate-aminotransferase	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
CP031131.1\|AXG01558.1\|2178985_2179429_-\|DNA-starvation/stationary-phase-protection-protein	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	1.22744e-67
CP031131.1\|AXG01557.1\|2178154_2178865_+\|purine-nucleoside-phosphorylase	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
CP031131.1\|AXG01572.1\|2190612_2191395_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	3.34326e-106
CP031131.1\|AXG01565.1\|2185317_2186298_+\|cation-transporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	1.20197e-108
CP031131.1\|AXG01574.1\|2194112_2195651_+\|PTS-mannitol-transporter-subunit-IICB	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
CP031131.1\|AXG01575.1\|2195685_2197818_+\|PRD-domain-containing-protein	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	4.68454e-68
CP031131.1\|AXG01559.1\|2179628_2180042_-\|thiol-disulfide-oxidoreductase-DCC-family-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	1.45785e-45
CP031131.1\|AXG01563.1\|2184178_2184844_-\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.27122e-47

>CP031131.1|AXG01566.1|2186563_2187655_+|transcriptional-regulator
MFTYFKSAFKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQTIAIYSQFGQKPPVDAYLKVIAVLLIAAVVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGNYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKNKKVVTEPKNTKVENDKETTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>CP031131.1|AXG01565.1|2185317_2186298_+|cation-transporter
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALVAFIYAEKNATTTKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHAH
>CP031131.1|AXG01564.1|2184995_2185316_+|ArsR-family-transcriptional-regulator
MSEQYSEIHTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>CP031131.1|AXG01563.1|2184178_2184844_-|SDR-family-NAD(P)-dependent-oxidoreductase
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSMIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFDGKGEIPREDVATVLKEIVTSNHFNHQEFQIISGEQDIKDALTQFEIEKD
>CP031131.1|AXG01562.1|2182804_2183743_-|class-I-mannose-6-phosphate-isomerase
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGTSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQRGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYV
>CP031131.1|AXG01561.1|2182543_2182774_-|hypothetical-protein
MKQFLYIALVCGVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>CP031131.1|AXG01560.1|2180498_2181872_-|EVE-domain-containing-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQITAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>CP031131.1|AXG01559.1|2179628_2180042_-|thiol-disulfide-oxidoreductase-DCC-family-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIKLITALPNRTKLLGVGLWFVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>CP031131.1|AXG01558.1|2178985_2179429_-|DNA-starvation/stationary-phase-protection-protein
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLENAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>CP031131.1|AXG01557.1|2178154_2178865_+|purine-nucleoside-phosphorylase
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>CP031131.1|AXG01567.1|2188087_2188192_-|hypothetical-protein
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK
>CP031131.1|AXG01568.1|2188624_2188807_-|hypothetical-protein
MIIFRFKVNAFFPVKLCLMIRFCLESCCIFRRHLLITFHNIRSKFIMFKYISSKCIICTG
>CP031131.1|AXG01569.1|2188871_2189030_+|integrase
MSKSSDALFNSLTQSFELIEGVYNELVTDNLKIVMYKPRKESTSGRINRRFK
>CP031131.1|AXG01570.1|2189465_2189558_+|erm-Leader-peptide
MTYGSIVAILCALFVIFFIPYMEKKDKKKK
>CP031131.1|AXG01571.1|2189687_2190545_-|Cof-type-HAD-IIB-family-hydrolase
MDNVKAIFLDMDGTILHENNQASTYTKDVINQLREKGYKVFLATGRSHSEIHQLVPQDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQITNLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITTFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQDETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>CP031131.1|AXG01572.1|2190612_2191395_-|ABC-transporter-ATP-binding-protein
MLIQLDQVGRMKQGKTILKNISWQINGGDKWILYGLNGAGKTTLLNILNAYEPATTGDVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEIRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSESYPTLAMIYVTHFIEEITSNFTKILLLKDGKSVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>CP031131.1|AXG01573.1|2191626_2193432_-|glutamine--fructose-6-phosphate-aminotransferase
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKGEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>CP031131.1|AXG01574.1|2194112_2195651_+|PTS-mannitol-transporter-subunit-IICB
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIAGFKILAPLMKFIMHILSVAVEALVHAHLLPLVSILVEPAKIVFLNNAINHGVFTPLGADQAAKAGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKSPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>CP031131.1|AXG01575.1|2195685_2197818_+|PRD-domain-containing-protein
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGTDSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVNKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIEIYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHVETKDIDGNTSFENEQTSYLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDAINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMVLITVLEEPLILPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>CP031131.1|AXG01576.1|2197829_2198264_+|mannitol-specific-phosphotransferase-enzyme-IIA-component
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA

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Click the colored protein region to show detailed information

Crispr_ID: CP031131_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP031131_7

2453593-2453690

Orphan

Consensus_repeat	Method
TTTCTGCGAATTTTATGAGCTAGAAAGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP031131_7

>merge|CP031131|7|2453593-2453690|CRISPRCasFinder
TTTCTGCGAATTTTATGAGCTAGAAAGGCTTATGCATTAGTAGCGAAGCTATCTAATGCGTTCCTTTATTTTCTGCGAATTTTATGAGCTAGAAAGGC

>CP031131|7|7|2453593-2453690|CRISPRCasFinder
TTTCTGCGAATTTTATGAGCTAGAAAGGC	TTATGCATTAGTAGCGAAGCTATCTAATGCGTTCCTTTAT
TTTCTGCGAATTTTATGAGCTAGAAAGGC

Protein	Signature genes	Signature genes Name	Protein_function
CP031131.1\|AXG01828.1\|2454205_2455516_+\|immunoglobulin-binding-protein-sbi	unknown	unknown	gnl\|CDD\|288473
CP031131.1\|AXG01819.1\|2445411_2445774_-\|DUF4467-domain-containing-protein	unknown	unknown	gnl\|CDD\|291399
CP031131.1\|AXG01825.1\|2451573_2452260_-\|2,3-bisphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518
CP031131.1\|AXG01832.1\|2457546_2458494_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	unknown	unknown	gnl\|CDD\|369625
CP031131.1\|AXG01834.1\|2459524_2459992_-\|QueT-transporter-family-protein	unknown	unknown	gnl\|CDD\|377623
CP031131.1\|AXG01818.1\|2444793_2445393_-\|DsbA-family-protein	unknown	unknown	gnl\|CDD\|224565
CP031131.1\|AXG01836.1\|2460705_2461821_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	unknown	unknown	gnl\|CDD\|223234
CP031131.1\|AXG01822.1\|2448103_2448823_-\|amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223836
CP031131.1\|AXG01823.1\|2448803_2449583_-\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270429
CP031131.1\|AXG01829.1\|2455419_2455605_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01827.1\|2454006_2454111_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01833.1\|2458495_2459473_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	unknown	unknown	gnl\|CDD\|273388
CP031131.1\|AXG01835.1\|2460002_2460695_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342
CP031131.1\|AXG01831.1\|2456050_2456980_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	unknown	unknown	gnl\|CDD\|369625
CP031131.1\|AXG01824.1\|2451315_2451420_+\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG02214.1\|2449703_2451107_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
CP031131.1\|AXG01821.1\|2447375_2448107_-\|amino-acid-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224051
CP031131.1\|AXG01830.1\|2455733_2455916_-\|hypothetical-protein	unknown	unknown	unknown
CP031131.1\|AXG01826.1\|2452586_2453453_-\|cation-transporter	unknown	unknown	gnl\|CDD\|223131
CP031131.1\|AXG01820.1\|2446028_2447279_+\|FemA/FemB-family-glycyltransferase-FmhA	unknown	unknown	gnl\|CDD\|367067

Protein	Function_ID	Function_description	E-value
CP031131.1\|AXG01828.1\|2454205_2455516_+\|immunoglobulin-binding-protein-sbi	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	1.70632e-25
CP031131.1\|AXG01819.1\|2445411_2445774_-\|DUF4467-domain-containing-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	3.11961e-31
CP031131.1\|AXG01825.1\|2451573_2452260_-\|2,3-bisphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167
CP031131.1\|AXG01832.1\|2457546_2458494_+\|bi-component-gamma-hemolysin-HlgCB-subunit-C	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	7.97441e-93
CP031131.1\|AXG01834.1\|2459524_2459992_-\|QueT-transporter-family-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.00158559
CP031131.1\|AXG01818.1\|2444793_2445393_-\|DsbA-family-protein	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	2.24775e-30
CP031131.1\|AXG01836.1\|2460705_2461821_-\|pyridoxal-phosphate-dependent-aminotransferase-family-protein	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	1.99808e-138
CP031131.1\|AXG01822.1\|2448103_2448823_-\|amino-acid-ABC-transporter-permease	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	4.98247e-78
CP031131.1\|AXG01823.1\|2448803_2449583_-\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.11829e-100
CP031131.1\|AXG01833.1\|2458495_2459473_+\|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	5.50766e-128
CP031131.1\|AXG01835.1\|2460002_2460695_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	2.9803e-130
CP031131.1\|AXG01826.1\|2452586_2453453_-\|cation-transporter	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	2.54055e-90
CP031131.1\|AXG02214.1\|2449703_2451107_-\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.06541e-91
CP031131.1\|AXG01821.1\|2447375_2448107_-\|amino-acid-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	3.20826e-144
CP031131.1\|AXG01831.1\|2456050_2456980_+\|bi-component-gamma-hemolysin-HlgAB-subunit-A	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.31899e-97
CP031131.1\|AXG01820.1\|2446028_2447279_+\|FemA/FemB-family-glycyltransferase-FmhA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0

>CP031131.1|AXG01826.1|2452586_2453453_-|cation-transporter
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNAPRLFKEDDVVPNAITIIVSLISGLVMLIVFAVNQRLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>CP031131.1|AXG01825.1|2451573_2452260_-|2,3-bisphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>CP031131.1|AXG01824.1|2451315_2451420_+|hypothetical-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>CP031131.1|AXG02214.1|2449703_2451107_-|MFS-transporter
MLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGISIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGVVLVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFSPTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
>CP031131.1|AXG01823.1|2448803_2449583_-|amino-acid-ABC-transporter-substrate-binding-protein
MKRLLFVMIAFVFILAACGNNSSKDKEANKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKEEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSRSAFAFSKKADDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>CP031131.1|AXG01822.1|2448103_2448823_-|amino-acid-ABC-transporter-permease
MFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>CP031131.1|AXG01821.1|2447375_2448107_-|amino-acid-ABC-transporter-ATP-binding-protein
MIQLNNIHKSFNDVEVIKGIDLSVEQGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVYVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKDEARGKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAKEVSNNIVFIHEGMIGEQGAPEEMFNRPKTEELRRFLNVINEE
>CP031131.1|AXG01820.1|2446028_2447279_+|FemA/FemB-family-glycyltransferase-FmhA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHRVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKHNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDTLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEALKESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPMFYKIQQYLNHKRR
>CP031131.1|AXG01819.1|2445411_2445774_-|DUF4467-domain-containing-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYDFSDKRVSYKQDFDSRRYYQQHDADYHEENMTN
>CP031131.1|AXG01818.1|2444793_2445393_-|DsbA-family-protein
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPFCKELDEKVMPKLRKNYIDNHKVEYQFVNLAFLGKDSIVGSRASHAVLMYAPKSFLDFQKQLFAAQQDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKDNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>CP031131.1|AXG01827.1|2454006_2454111_-|hypothetical-protein
MLTNRLTSVNYVKKRLIQNIQRILSKEVLYGEMQ
>CP031131.1|AXG01828.1|2454205_2455516_+|immunoglobulin-binding-protein-sbi
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDKSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAITKLQKNDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYTDKYFKYKGTIDKTVLSVFGNGYKSYIQPLKVEDQKNYVSKSYAQVRNYVTETLNTGKVLYAFYQNPKVVKAAITTAETASSIKNTLSNLLSFWK
>CP031131.1|AXG01829.1|2455419_2455605_-|hypothetical-protein
MENQRFFLITVYYENYLKNDVKLEKILLIDYFQNDNKLLNVFLIDDAVSAVVIAALTTFGF
>CP031131.1|AXG01830.1|2455733_2455916_-|hypothetical-protein
MMFLHYVMFKRFIGRRRLYSYITMFCKSYSIELLFNYGACSGRGMDCAIVCENLKLIKLS
>CP031131.1|AXG01831.1|2456050_2456980_+|bi-component-gamma-hemolysin-HlgAB-subunit-A
MIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>CP031131.1|AXG01832.1|2457546_2458494_+|bi-component-gamma-hemolysin-HlgCB-subunit-C
MLKNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN
>CP031131.1|AXG01833.1|2458495_2459473_+|bi-component-gamma-hemolysin-HlgAB/HlgCB-subunit-B
MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>CP031131.1|AXG01834.1|2459524_2459992_-|QueT-transporter-family-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSLLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTMRKRMAVLLR
>CP031131.1|AXG01835.1|2460002_2460695_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQHLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDNRIDLNHYISFLESTPKQVVYETV
>CP031131.1|AXG01836.1|2460705_2461821_-|pyridoxal-phosphate-dependent-aminotransferase-family-protein
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIQKIIISDSVFSTNGDVVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDIDRLFEILHQED

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	136745-136769	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	341725-341749	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	616758-616782	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	787179-787203	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	787237-787261	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	787295-787319	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	787353-787377	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	1040911-1040935	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	1351032-1351056	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	1439618-1439642	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	1618757-1618781	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	1796223-1796247	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	1942281-1942305	1	0.96
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	2292723-2292747	1	0.96
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	CP031131.1	616825-616855	1	0.968
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	CP031131.1	1040838-1040868	1	0.968
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	CP031131.1	1141296-1141326	1	0.968
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	CP031131.1	1351099-1351129	1	0.968
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	CP031131.1	1618684-1618714	1	0.968
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	CP031131.1	2292767-2292797	1	0.968
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	CP031131.1	2581744-2581774	1	0.968
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	781687-781711	2	0.92
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	794494-794518	2	0.92
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	1355522-1355546	2	0.92
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	2303642-2303666	2	0.92
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	CP031131.1	2632163-2632187	2	0.92
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	CP031131.1	787106-787136	2	0.935
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	CP031131.1	2303683-2303713	2	0.935

1. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 136745-136769, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

2. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 341725-341749, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctatgttg	Protospacer
******************* *****

3. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 616758-616782, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

4. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 787179-787203, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

5. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 787237-787261, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

6. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 787295-787319, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

7. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 787353-787377, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

8. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 1040911-1040935, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

9. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 1351032-1351056, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

10. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 1439618-1439642, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

11. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 1618757-1618781, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

12. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 1796223-1796247, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

13. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 1942281-1942305, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

14. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 2292723-2292747, mismatch: 1, identity: 0.96

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgtgttg	Protospacer
******************* *****

15. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to position: 616825-616855, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

16. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to position: 1040838-1040868, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

17. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to position: 1141296-1141326, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

18. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to position: 1351099-1351129, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

19. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to position: 1618684-1618714, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

20. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to position: 2292767-2292797, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

21. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to position: 2581744-2581774, mismatch: 1, identity: 0.968

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtcagct	Protospacer
********.**********************

22. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 781687-781711, mismatch: 2, identity: 0.92

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctttatgttg	Protospacer
*****************.* *****

23. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 794494-794518, mismatch: 2, identity: 0.92

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcatttcgaaattctctgtgttg	Protospacer
**** ************** *****

24. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 1355522-1355546, mismatch: 2, identity: 0.92

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttatcgaaattctctgtgttg	Protospacer
****** ************ *****

25. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 2303642-2303666, mismatch: 2, identity: 0.92

tttcttttcgaaattctctttgttg	CRISPR spacer
tttctttttgaaattctctatgttg	Protospacer
********.********** *****

26. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to position: 2632163-2632187, mismatch: 2, identity: 0.92

tttcttttcgaaattctctttgttg	CRISPR spacer
tttcttttcgaaattctctgttttg	Protospacer
******************* * ***

27. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to position: 787106-787136, mismatch: 2, identity: 0.935

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtaagctgacttttcgtaagct	Protospacer
********.***************** ****

28. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to position: 2303683-2303713, mismatch: 2, identity: 0.935

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
cacattattgtatgctgacttttcgtcagct	Protospacer
********.*** ******************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP031131_1	1.1\|241895\|25\|CP031131\|CRISPRCasFinder	241895-241919	25	LC371242	Escherichia phage EcS1 DNA, complete sequence	15447-15471	2	0.92
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	NC_021536	Synechococcus phage S-IOM18 genomic sequence	159749-159779	8	0.742
CP031131_5	5.1\|1940868\|31\|CP031131\|CRISPRCasFinder	1940868-1940898	31	LN846932	Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome	10622-10652	8	0.742

1. spacer 1.1|241895|25|CP031131|CRISPRCasFinder matches to LC371242 (Escherichia phage EcS1 DNA, complete sequence) position: , mismatch: 2, identity: 0.92

tttcttttcgaaattctctttgttg	CRISPR spacer
tttctttacgaaattctttttgttg	Protospacer
******* *********.*******

2. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to NC_021536 (Synechococcus phage S-IOM18 genomic sequence) position: , mismatch: 8, identity: 0.742

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
aattttatcgtaaggtgagttttcgtcaagc	Protospacer
 *. ********** *** *********. .

3. spacer 5.1|1940868|31|CP031131|CRISPRCasFinder matches to LN846932 (Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome) position: , mismatch: 8, identity: 0.742

cacattatcgtaagctgacttttcgtcagct	CRISPR spacer
taatttatcgtaatctgatttttcgtcttca	Protospacer
.*  ********* ****.********  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

719154 : 726973

Hokovirus(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG00164.1\|719154_720210_-	two-component sensor histidine kinase	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
AXG00165.1\|720209_720896_-	DNA-binding response regulator	NA	NA	NA	NA
AXG00166.1\|720870_721344_-	DoxX family protein	NA	NA	NA	NA
AXG00167.1\|721684_722125_-	hypothetical protein	NA	NA	NA	NA
AXG00168.1\|722404_722989_-	hypothetical protein	NA	NA	NA	NA
AXG00169.1\|723087_723801_-	7-carboxy-7-deazaguanine synthase QueE	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
AXG00170.1\|723804_724224_-	6-carboxytetrahydropterin synthase QueD	S4U060	uncultured_phage	6.3e-07	28.7
AXG00171.1\|724225_724894_-	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.5
AXG00172.1\|725244_725838_+	aminodeoxychorismate/anthranilate synthase component II	A0A0P0IKJ1	Acinetobacter_phage	4.4e-38	42.9
AXG00173.1\|725821_726973_+	anthranilate synthase component I family protein	S4VNU7	Pandoravirus	7.8e-23	35.7

DBSCAN-SWA_2

738943 : 752534

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG00182.1\|738943_740002_+	histidinol-phosphate transaminase	A0A1X6WGT4	Pacmanvirus	7.9e-22	26.7
AXG00183.1\|740296_740839_+	5'(3')-deoxyribonucleotidase	NA	NA	NA	NA
AXG00184.1\|740951_741050_+	hypothetical protein	NA	NA	NA	NA
AXG00185.1\|741462_742380_-	diacylglycerol kinase family lipid kinase	A0A1V0SBJ0	Catovirus	2.8e-07	22.4
AXG00186.1\|742469_742571_+	hypothetical protein	NA	NA	NA	NA
AXG00187.1\|742648_744154_-	peptide MFS transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
AXG00188.1\|744219_744465_-	hypothetical protein	NA	NA	NA	NA
AXG00189.1\|744494_744995_-	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	5.9e-52	71.5
AXG00190.1\|745014_745881_-	DMT family transporter	NA	NA	NA	NA
AXG00191.1\|746694_747093_+	protein NrdI	A0A2H4J545	uncultured_Caudovirales_phage	1.2e-52	72.0
AXG00192.1\|747055_749161_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
AXG00193.1\|749278_750250_+	class 1b ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
AXG00194.1\|750430_750586_+	hypothetical protein	NA	NA	NA	NA
AXG00195.1\|751577_752534_+	iron ABC transporter permease	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8

DBSCAN-SWA_3

837596 : 883493

Staphylococcus_virus(50.0%)

terminase,head,tail,holin,integrase,plate,capsid,portal

attL 835684:835700|attR 869536:869552

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
835684:835700	attL	NA	NA	NA	NA
AXG00280.1\|837596_838838_+	cysteine desulfurase	Q2XUY6	environmental_halophage	8.2e-111	44.8
AXG00281.1\|838827_839292_+	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
AXG00282.1\|839442_840840_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
AXG00283.1\|840907_841957_-\|integrase	site-specific integrase	A1KWY3	Staphylococcus_virus	1.6e-203	100.0
AXG00284.1\|842019_842535_-	hypothetical protein	I1W624	Staphylococcus_phage	1.5e-37	100.0
AXG00285.1\|842538_843039_-	hypothetical protein	B7T094	Staphylococcus_virus	1.1e-71	100.0
AXG00286.1\|843089_843728_-	LexA family transcriptional regulator	E0Y3N7	Staphylococcus_virus	1.5e-116	100.0
AXG00287.1\|843918_844173_+	XRE family transcriptional regulator	A0A0E3T8G8	Staphylococcus_phage	3.1e-41	98.8
AXG00288.1\|844188_844980_+	phage antirepressor	E0Y3N9	Staphylococcus_virus	6.5e-146	100.0
AXG00289.1\|844980_845205_+	hypothetical protein	A0A0F6N4M2	Staphylococcus_phage	3.2e-34	100.0
AXG00290.1\|845244_845694_+	hypothetical protein	A0A0H3U2S4	Staphylococcus_phage	2.3e-79	100.0
AXG00291.1\|845707_845929_+	hypothetical protein	E0Y3P2	Staphylococcus_virus	1.5e-31	100.0
AXG00292.1\|845921_846089_+	DUF1270 family protein	S4V7J2	Staphylococcus_phage	4.0e-21	96.4
AXG00293.1\|846089_846410_+	hypothetical protein	S4V968	Staphylococcus_phage	4.8e-55	100.0
AXG00294.1\|846503_846764_+	DUF1108 family protein	A0A059T5A3	Staphylococcus_phage	1.2e-43	100.0
AXG00295.1\|846776_847313_+	hypothetical protein	A0A2I6PD93	Staphylococcus_phage	3.8e-81	99.4
AXG00296.1\|847313_847964_+	single-stranded DNA-binding protein	A0A0F6N3I5	Staphylococcus_phage	1.1e-119	100.0
AXG00297.1\|847960_848404_+	single-stranded DNA-binding protein	A0A2I6PD99	Staphylococcus_phage	3.2e-73	95.9
AXG00298.1\|848415_849090_+	hypothetical protein	A1KX69	Staphylococcus_virus	4.7e-129	97.8
AXG00299.1\|849199_849859_-	hypothetical protein	E0Y3Q0	Staphylococcus_virus	1.4e-120	100.0
AXG00300.1\|849904_850675_+	replication protein	A0A2H4PQI2	Staphylococcus_phage	9.0e-116	99.6
AXG00301.1\|850684_851458_+	AAA family ATPase	A0A2H4PQI3	Staphylococcus_phage	4.6e-144	100.0
AXG00302.1\|851451_851610_+	hypothetical protein	A0A2H4PQI7	Staphylococcus_phage	1.7e-21	98.1
AXG00303.1\|851623_851845_+	DUF3269 family protein	A0A2H4PQI9	Staphylococcus_phage	2.2e-35	100.0
AXG00304.1\|851855_852260_+	DUF1064 domain-containing protein	G4KNP2	Staphylococcus_phage	1.6e-68	100.0
AXG00305.1\|852264_852450_+	DUF3113 family protein	A0A2H4PQI8	Staphylococcus_phage	3.2e-27	100.0
AXG00306.1\|852450_852807_+	hypothetical protein	A0A0F6N3E3	Staphylococcus_phage	7.2e-60	99.2
AXG00307.1\|852810_853053_+	hypothetical protein	A0A1P8L6E3	Staphylococcus_phage	3.0e-41	100.0
AXG00308.1\|853067_853319_+	DUF1024 family protein	E0Y3Q8	Staphylococcus_virus	1.4e-38	100.0
AXG00309.1\|853482_853764_+	hypothetical protein	A0A2I6PDX3	Staphylococcus_phage	8.5e-48	100.0
AXG00310.1\|853940_854474_+	dUTPase	E0Y3R2	Staphylococcus_virus	6.0e-95	100.0
AXG00311.1\|854510_854717_+	DUF1381 domain-containing protein	Q4ZCV6	Staphylococcus_virus	2.7e-19	97.1
AXG02166.1\|854905_855109_+	hypothetical protein	B2ZYX5	Staphylococcus_phage	2.0e-30	97.0
AXG00312.1\|855101_855251_+	transcriptional regulator	A0A0H4ISR0	Staphylococcus_phage	7.7e-16	84.2
AXG00313.1\|855251_855614_+	hypothetical protein	Q4ZDW4	Staphylococcus_virus	5.2e-58	94.1
AXG00314.1\|855614_855761_+	hypothetical protein	E0Y3R6	Staphylococcus_virus	1.7e-15	100.0
AXG00315.1\|855775_856195_+	transcriptional regulator	B7T0C4	Staphylococcus_virus	1.1e-70	100.0
AXG00316.1\|856381_856822_+\|terminase	terminase small subunit	E0Y3R8	Staphylococcus_virus	1.3e-74	100.0
AXG00317.1\|856808_858086_+\|terminase	PBSX family phage terminase large subunit	A0EWS5	Staphylococcus_virus	1.1e-248	99.8
AXG00318.1\|858096_859632_+\|portal	phage portal protein	Q4ZDN2	Staphylococcus_virus	3.8e-291	99.6
AXG00319.1\|859638_860634_+\|head	phage head morphogenesis protein	E0Y3K7	Staphylococcus_virus	3.4e-184	100.0
AXG00320.1\|860706_860877_+	hypothetical protein	Q4ZDF2	Staphylococcus_virus	3.3e-23	100.0
AXG00321.1\|861011_861626_+	DUF4355 domain-containing protein	I1W646	Staphylococcus_phage	2.9e-40	100.0
AXG00322.1\|861639_862614_+\|capsid	phage major capsid protein	E0Y3L0	Staphylococcus_virus	2.2e-183	100.0
AXG00323.1\|862635_862923_+	hypothetical protein	S4V6D9	Staphylococcus_phage	4.7e-46	100.0
AXG00324.1\|862931_863264_+\|head,tail	phage head-tail adapter protein	E0Y3L2	Staphylococcus_virus	7.1e-54	100.0
AXG00325.1\|863260_863563_+	hypothetical protein	E0Y3L3	Staphylococcus_virus	2.0e-50	100.0
AXG00326.1\|863562_863910_+	hypothetical protein	E0Y3L4	Staphylococcus_virus	4.1e-60	100.0
AXG00327.1\|863921_864305_+	hypothetical protein	E0Y3L5	Staphylococcus_virus	2.6e-68	100.0
AXG00328.1\|864323_864905_+\|tail	phage major tail protein, TP901-1 family	A0A0F6N3L8	Staphylococcus_phage	4.9e-106	100.0
AXG00329.1\|864966_865332_+\|tail	phage tail protein	E0Y3L7	Staphylococcus_virus	9.6e-60	100.0
AXG00330.1\|865361_865706_+	hypothetical protein	A0A0F6N3F7	Staphylococcus_phage	2.5e-57	100.0
AXG00331.1\|869200_870148_+\|tail	phage tail family protein	E0Y3M0	Staphylococcus_virus	2.8e-183	100.0
869536:869552	attR	NA	NA	NA	NA
AXG00332.1\|870156_872058_+	peptidase	E0Y3M1	Staphylococcus_virus	0.0e+00	100.0
AXG00333.1\|872072_873983_+	hypothetical protein	Q8SDT4	Staphylococcus_phage	0.0e+00	100.0
AXG00334.1\|873982_875806_+\|plate	phage baseplate upper protein	E0Y3M3	Staphylococcus_virus	0.0e+00	100.0
AXG00335.1\|875805_876183_+	DUF2977 domain-containing protein	E0Y3M4	Staphylococcus_virus	2.6e-60	100.0
AXG02167.1\|876185_876359_+	XkdX family protein	A0A0F6N3L7	Staphylococcus_phage	6.6e-27	100.0
AXG00336.1\|876399_876699_+	DUF2951 domain-containing protein	A0A0F6N3M6	Staphylococcus_phage	9.9e-47	100.0
AXG00337.1\|876835_878734_+	CHAP domain-containing protein	E0Y3M7	Staphylococcus_virus	0.0e+00	100.0
AXG00338.1\|878746_879985_+	DUF2479 domain-containing protein	E0Y3M8	Staphylococcus_virus	3.5e-210	100.0
AXG00339.1\|879989_880385_+	hypothetical protein	Q4ZBP5	Staphylococcus_phage	2.7e-68	100.0
AXG00340.1\|880441_880696_+\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
AXG00341.1\|880707_881463_+	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
AXG00342.1\|881954_882749_+	phosphatidylinositol kinase	E0Y3N2	Staphylococcus_virus	4.9e-149	100.0
AXG00343.1\|882755_883493_+	hypothetical protein	E0Y3N3	Staphylococcus_virus	4.4e-136	100.0

DBSCAN-SWA_4

1042264 : 1050737

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG00489.1\|1042264_1042747_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	6.2e-22	44.7
AXG00490.1\|1042733_1043858_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
AXG00491.1\|1043861_1044566_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	M4R1E8	Synechococcus_phage	7.3e-48	42.1
AXG00492.1\|1044565_1044829_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
AXG00493.1\|1044830_1045502_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
AXG00494.1\|1045494_1047684_+	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	1.0e-140	39.7
AXG00495.1\|1047662_1049147_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	4.2e-45	31.5
AXG00496.1\|1049139_1050168_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	3.4e-62	41.7
AXG00497.1\|1050170_1050737_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	3.6e-29	40.1

DBSCAN-SWA_5

1590229 : 1598559

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG00991.1\|1590229_1591015_-	metal ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
AXG00992.1\|1591140_1592031_-	endonuclease	A0A2H4UU70	Bodo_saltans_virus	3.4e-26	36.0
AXG00993.1\|1592040_1593387_-	DEAD/DEAH box family ATP-dependent RNA helicase	A0A1V0SIR5	Klosneuvirus	2.4e-55	34.0
AXG00994.1\|1593500_1594601_-	Nif3-like dinuclear metal center hexameric protein	A0A1S5V250	Saudi_moumouvirus	5.2e-08	29.6
AXG00995.1\|1594603_1595281_-\|tRNA	tRNA (adenine-N(1))-methyltransferase	NA	NA	NA	NA
AXG00996.1\|1595411_1596518_-	RNA polymerase sigma factor SigA	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
AXG00997.1\|1596741_1598559_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	3.6e-54	36.0

DBSCAN-SWA_6

1667897 : 1676937

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG01066.1\|1667897_1668416_-	adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
AXG01067.1\|1668437_1670708_-	single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	2.4e-63	29.3
AXG01068.1\|1670910_1673190_-	protein translocase subunit SecDF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
AXG01069.1\|1673464_1673725_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
AXG01070.1\|1673743_1674883_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	1.6e-84	44.7
AXG01071.1\|1674905_1675931_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
AXG01072.1\|1675932_1676937_-	Holliday junction branch migration DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_7

1817108 : 1862600

Staphylococcus_phage(94.87%)

protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG01194.1\|1817108_1818110_+	proline dehydrogenase	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
AXG01195.1\|1818231_1818696_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
AXG01196.1\|1818708_1819890_-	riboflavin biosynthesis protein RibBA	A0A2H4PQS2	Staphylococcus_phage	6.6e-227	99.7
AXG01197.1\|1819900_1820533_-	riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.7e-112	99.5
AXG01198.1\|1820539_1821571_-	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	A0A2H4PQS8	Staphylococcus_phage	4.0e-196	98.8
AXG01199.1\|1822063_1823566_-	pyridine nucleotide-disulfide oxidoreductase	A0A2H4PQX2	Staphylococcus_phage	1.9e-29	98.6
AXG01200.1\|1824088_1824403_+	ArsR family transcriptional regulator	A0A2H4PQT4	Staphylococcus_phage	9.8e-53	98.1
AXG01201.1\|1824402_1825695_+	arsenical efflux pump membrane protein ArsB	A0A2H4PQU3	Staphylococcus_phage	5.0e-228	99.5
AXG01202.1\|1825781_1826636_-	autolysin	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
AXG01203.1\|1826911_1827136_-	hypothetical protein	NA	NA	NA	NA
AXG01204.1\|1827334_1827805_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	1.0e-82	99.4
AXG01205.1\|1827917_1828361_+	competence protein ComK	NA	NA	NA	NA
AXG01206.1\|1828347_1828791_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	7.1e-57	98.0
AXG01207.1\|1829086_1829722_+\|protease	CPBP family intramembrane metalloprotease SdpA	NA	NA	NA	NA
AXG01208.1\|1830161_1830875_-	transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
AXG01209.1\|1831134_1831437_+	hypothetical protein	NA	NA	NA	NA
AXG01210.1\|1831692_1832058_+	fluoride efflux transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	3.6e-59	100.0
AXG01211.1\|1832054_1832408_+	CrcB family protein	A0A2H4PQQ7	Staphylococcus_phage	1.0e-21	94.9
AXG01212.1\|1834405_1835239_-	aldo/keto reductase	A0A2H4PQR8	Staphylococcus_phage	3.5e-158	99.6
AXG01213.1\|1835450_1836359_-	NERD domain-containing protein	A0A2H4PQQ8	Staphylococcus_phage	3.4e-138	100.0
AXG01214.1\|1836483_1837677_-	S-adenosylmethionine synthase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
AXG01215.1\|1838048_1839641_+	phosphoenolpyruvate carboxykinase (ATP)	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	100.0
AXG02195.1\|1839893_1840640_-	S9 family peptidase	A0A2H4PQM6	Staphylococcus_phage	1.3e-143	99.6
AXG01216.1\|1840644_1841118_-	nucleoside triphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	5.5e-84	99.4
AXG01217.1\|1841183_1841441_+	membrane protein insertion efficiency factor YidD	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
AXG01218.1\|1841437_1842439_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	5.1e-188	98.8
AXG01219.1\|1842443_1843922_-	o-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.5e-284	98.2
AXG02196.1\|1844080_1844536_-	DUF4909 domain-containing protein	A0A2H4PQN7	Staphylococcus_phage	1.0e-79	99.3
AXG01220.1\|1844838_1845489_+	calcium-binding protein	A0A2H4PQM8	Staphylococcus_phage	5.2e-56	98.6
AXG01221.1\|1845569_1846565_+	DUF4352 domain-containing protein	A0A2H4PQN2	Staphylococcus_phage	9.6e-70	94.4
AXG01222.1\|1846638_1847265_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	1.3e-88	91.3
AXG01223.1\|1847305_1847647_+	DUF3969 family protein	A0A2H4PQN6	Staphylococcus_phage	3.9e-55	95.6
AXG01224.1\|1848516_1849074_-	ImmA/IrrE family metallo-endopeptidase	A0A2H4PQN8	Staphylococcus_phage	3.1e-78	97.5
AXG01225.1\|1849258_1849702_-	DUF1433 domain-containing protein	NA	NA	NA	NA
AXG01226.1\|1850348_1851467_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	7.6e-39	35.1
AXG01227.1\|1851459_1853199_-	type I restriction-modification system subunit M	A0A2H4PQP4	Staphylococcus_phage	9.9e-288	99.2
AXG01228.1\|1853179_1853314_-	hypothetical protein	NA	NA	NA	NA
AXG01229.1\|1853378_1854098_-\|protease	serine protease SplD	A0A2H4PQP9	Staphylococcus_phage	5.1e-129	99.2
AXG01230.1\|1854218_1854938_-\|protease	serine protease SplC	A0A2H4PQP7	Staphylococcus_phage	1.2e-130	99.2
AXG01231.1\|1854995_1855718_-\|protease	serine protease SplB	A0A2H4PQN0	Staphylococcus_phage	6.4e-132	100.0
AXG01232.1\|1855842_1856550_-\|protease	serine protease SplA	A0A2H4PQN3	Staphylococcus_phage	1.6e-127	97.9
AXG01233.1\|1856985_1857204_-	hypothetical protein	NA	NA	NA	NA
AXG01234.1\|1857513_1858092_+	DUF4888 domain-containing protein	A0A2H4PQH6	Staphylococcus_phage	1.9e-49	59.6
AXG01235.1\|1858565_1858784_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	1.4e-26	81.9
AXG01236.1\|1859039_1859513_+	hypothetical protein	NA	NA	NA	NA
AXG01237.1\|1859517_1860309_+	DUF1828 domain-containing protein	NA	NA	NA	NA
AXG01238.1\|1860679_1861663_-	bi-component leukocidin LukED subunit D	A0A2H4PQH7	Staphylococcus_phage	1.8e-185	99.4
AXG01239.1\|1861664_1862600_-	beta-channel forming cytolysin	A0A2H4PQI5	Staphylococcus_phage	1.4e-174	100.0

DBSCAN-SWA_8

1952210 : 2053525

119

Staphylococcus_phage(85.0%)

terminase,transposase,head,tail,holin,tRNA,integrase,capsid,portal,protease

attL 2027184:2027201|attR 2051512:2051529

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG01324.1\|1952210_1953638_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase GatCAB subunit B	NA	NA	NA	NA
AXG01325.1\|1953650_1955108_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase GatCAB subunit A	NA	NA	NA	NA
AXG01326.1\|1955109_1955412_-\|tRNA	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase GatCAB subunit C	NA	NA	NA	NA
AXG01327.1\|1955779_1957318_+	sodium:proline symporter	NA	NA	NA	NA
AXG01328.1\|1957406_1958606_-	CamS family sex pheromone protein	NA	NA	NA	NA
AXG01329.1\|1958618_1960622_-	DNA ligase (NAD(+)) LigA	A0A0K2QQN8	Ralstonia_phage	5.8e-114	36.1
AXG01330.1\|1960625_1962818_-	DNA helicase PcrA	A7KV33	Bacillus_phage	1.0e-135	42.2
AXG01331.1\|1962814_1963507_-	geranylgeranylglyceryl/heptaprenylglyceryl phosphate synthase	NA	NA	NA	NA
AXG01332.1\|1963678_1963981_-	hypothetical protein	NA	NA	NA	NA
AXG01333.1\|1964088_1965384_-	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	1.6e-16	32.9
AXG01334.1\|1966244_1967411_+\|protease	cysteine protease staphopain A	NA	NA	NA	NA
AXG01335.1\|1967441_1967768_+	staphostatin A	NA	NA	NA	NA
AXG01336.1\|1968059_1968233_-	NETI motif-containing protein	NA	NA	NA	NA
AXG01337.1\|1968213_1968816_-	DUF2179 domain-containing protein	NA	NA	NA	NA
AXG01338.1\|1969086_1969908_-	NAD(+) synthetase	G3MA24	Bacillus_virus	2.3e-69	52.7
AXG01339.1\|1969900_1971370_-	nicotinate phosphoribosyltransferase	G3MA18	Bacillus_virus	3.5e-108	45.1
AXG01340.1\|1971553_1972630_+	nitric oxide synthase oxygenase	NA	NA	NA	NA
AXG01341.1\|1972649_1973444_+	ACT domain-containing protein	NA	NA	NA	NA
AXG01342.1\|1973515_1973623_+	hypothetical protein	NA	NA	NA	NA
AXG01343.1\|1973633_1975196_-	SLC13 family permease	NA	NA	NA	NA
AXG01344.1\|1975400_1976498_-	pectate lyase	U5PWM6	Bacillus_phage	2.5e-47	34.9
AXG01345.1\|1976869_1977430_+	cysteine hydrolase	G3MA16	Bacillus_virus	2.0e-32	41.2
AXG01346.1\|1977482_1978412_+	manganese-dependent inorganic pyrophosphatase	NA	NA	NA	NA
AXG01347.1\|1978604_1978778_-	hypothetical protein	NA	NA	NA	NA
AXG01348.1\|1978829_1980209_+	aldehyde dehydrogenase	NA	NA	NA	NA
AXG01349.1\|1980328_1981357_-	hypothetical protein	NA	NA	NA	NA
AXG01350.1\|1982184_1983942_-	beta-lactam sensor/signal transducer BlaR1	NA	NA	NA	NA
AXG01351.1\|1984048_1984894_+	penicillin-hydrolyzing class A beta-lactamase BlaZ	A0A1B0VBP7	Salmonella_phage	3.4e-31	34.3
AXG01352.1\|1984944_1986624_-\|transposase	IS1182 family transposase	A0ZS58	Staphylococcus_virus	4.2e-243	77.4
AXG01353.1\|1986947_1988267_+\|transposase	ISL3-like element IS1181 family transposase	NA	NA	NA	NA
AXG01354.1\|1988526_1989705_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	2.3e-62	38.0
AXG01355.1\|1990186_1990606_+	YolD-like family protein	U3PG23	Staphylococcus_phage	1.1e-30	54.2
AXG01356.1\|1990634_1991000_-\|transposase	transposase	NA	NA	NA	NA
AXG02200.1\|1991008_1993036_-\|transposase	transposase	NA	NA	NA	NA
AXG01357.1\|1993074_1994226_-\|transposase	transposase	P97010	Streptococcus_pyogenes_phage	9.0e-11	31.0
AXG01358.1\|1994732_1994906_-	hypothetical protein	NA	NA	NA	NA
AXG01359.1\|1995356_1996397_+	linear amide C-N hydrolase	NA	NA	NA	NA
AXG01360.1\|1996453_1997296_-	hypothetical protein	NA	NA	NA	NA
AXG01361.1\|1997292_1997850_-	DUF1700 domain-containing protein	NA	NA	NA	NA
AXG01362.1\|1997909_1998434_-	hypothetical protein	NA	NA	NA	NA
AXG01363.1\|1998554_1999118_+	thioredoxin family protein	NA	NA	NA	NA
AXG01364.1\|1999183_1999924_-	phenol-soluble modulin export ABC transporter permease subunit PmtD	NA	NA	NA	NA
AXG01365.1\|1999923_2000796_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtC	A0A2H4PQG7	Staphylococcus_phage	6.1e-28	35.2
AXG01366.1\|2000792_2001473_-	phenol-soluble modulin export ABC transporter permease subunit PmtB	NA	NA	NA	NA
AXG01367.1\|2001473_2002370_-	phenol-soluble modulin export ABC transporter ATP-binding protein PmtA	A0A2H4PQG7	Staphylococcus_phage	1.1e-16	30.2
AXG01368.1\|2002366_2002747_-	GntR family transcriptional regulator	NA	NA	NA	NA
AXG01369.1\|2003005_2003182_-	hypothetical protein	NA	NA	NA	NA
AXG01370.1\|2003424_2003523_-	hypothetical protein	NA	NA	NA	NA
AXG01371.1\|2003722_2005009_+	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
AXG01372.1\|2005332_2005623_-	MAP domain-containing protein	NA	NA	NA	NA
AXG01373.1\|2005633_2007382_-	MAP domain-containing protein	NA	NA	NA	NA
AXG01374.1\|2007767_2007968_+	hypothetical protein	A0A1P8L6A7	Staphylococcus_phage	3.4e-27	100.0
AXG01375.1\|2008339_2008519_+	hypothetical protein	A0A1W6JQ29	Staphylococcus_phage	2.2e-25	100.0
AXG01376.1\|2008542_2008851_+	hypothetical protein	M9NTD8	Staphylococcus_phage	2.1e-39	100.0
AXG01377.1\|2008829_2009090_+	hypothetical protein	M9NS66	Staphylococcus_phage	2.3e-23	100.0
AXG01378.1\|2010166_2010616_+	chemotaxis inhibitory protein	A0A1P8L6A8	Staphylococcus_phage	1.1e-78	100.0
AXG01379.1\|2010710_2011169_-	amidase	R9QTN8	Staphylococcus_phage	4.9e-85	98.7
AXG01380.1\|2011695_2012187_-	staphylokinase	A0A1X9H028	Staphylococcus_phage	9.5e-87	100.0
AXG01381.1\|2012377_2013133_-	CHAP domain-containing protein	D2JLG5	Staphylococcus_phage	3.4e-152	100.0
AXG01382.1\|2013144_2013399_-\|holin	phage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
AXG01383.1\|2013450_2013558_+	hypothetical protein	NA	NA	NA	NA
AXG01384.1\|2013610_2013787_-\|holin	putative holin-like toxin	D2JLG3	Staphylococcus_phage	2.2e-22	98.3
AXG01385.1\|2013936_2014233_-	DUF2951 domain-containing protein	D2JLG2	Staphylococcus_phage	2.9e-46	100.0
AXG01386.1\|2014290_2014578_-	hypothetical protein	D2JLG1	Staphylococcus_phage	1.3e-43	100.0
AXG01387.1\|2014624_2014777_-	hypothetical protein	D2JLG0	Staphylococcus_phage	5.2e-20	100.0
AXG01388.1\|2014766_2018552_-	hypothetical protein	A0A1X9H0H3	Staphylococcus_phage	0.0e+00	98.5
AXG01389.1\|2018567_2020052_-\|tail	phage tail protein	A0A2I6PDJ0	Staphylococcus_phage	1.2e-297	100.0
AXG01390.1\|2020048_2024578_-\|tail	phage tail tape measure protein	A0A2I6PDK2	Staphylococcus_phage	0.0e+00	99.8
AXG01391.1\|2024822_2025173_-	hypothetical protein	G4KNQ8	Staphylococcus_phage	7.8e-59	100.0
AXG01392.1\|2025222_2025447_-	hypothetical protein	A0A075LYE8	Staphylococcus_phage	3.0e-32	100.0
AXG01393.1\|2025488_2026133_-\|tail	phage tail protein	A0A1X9H0J2	Staphylococcus_phage	1.5e-119	100.0
AXG01394.1\|2026133_2026541_-	hypothetical protein	G4KNQ6	Staphylococcus_phage	7.1e-72	100.0
AXG01395.1\|2026537_2026942_-	hypothetical protein	G4KNQ5	Staphylococcus_phage	2.1e-68	99.3
AXG01396.1\|2026938_2027301_-\|head,tail	phage head-tail adapter protein	G4KNQ4	Staphylococcus_phage	4.4e-65	100.0
2027184:2027201	attL	NA	NA	NA	NA
AXG01397.1\|2027284_2027569_-\|head,tail	phage head-tail adapter protein	A0A2I6PDJ5	Staphylococcus_phage	2.3e-45	100.0
AXG01398.1\|2027558_2027843_-	hypothetical protein	A0A2I6PDJ3	Staphylococcus_phage	1.8e-45	100.0
AXG01399.1\|2027862_2029008_-\|capsid	phage major capsid protein	G4KNQ3	Staphylococcus_phage	9.6e-215	100.0
AXG01400.1\|2029031_2029769_-\|protease	Clp protease ClpP	G4KNQ2	Staphylococcus_phage	1.8e-129	100.0
AXG01401.1\|2029752_2030940_-\|portal	phage portal protein	A0A2I6PDI1	Staphylococcus_phage	1.0e-219	100.0
AXG01402.1\|2030955_2032617_-\|terminase	terminase large subunit	A0A2I6PDJ8	Staphylococcus_phage	0.0e+00	100.0
AXG01403.1\|2032613_2032958_-	hypothetical protein	G4KNP9	Staphylococcus_phage	9.4e-57	100.0
AXG01404.1\|2033088_2033388_-	HNH endonuclease	A0EWY8	Staphylococcus_phage	4.6e-52	100.0
AXG01405.1\|2033619_2034036_-	transcriptional regulator	G4KNP7	Staphylococcus_phage	1.3e-76	100.0
AXG01406.1\|2034063_2034264_-	DUF1514 domain-containing protein	A0A2I6PDV9	Staphylococcus_phage	4.0e-28	98.5
AXG01407.1\|2034263_2034413_-	transcriptional regulator	A0A1W6JPZ2	Staphylococcus_phage	4.8e-18	100.0
AXG01408.1\|2034409_2034796_-	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
AXG01409.1\|2034792_2034999_-	DUF1381 domain-containing protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
AXG01410.1\|2034995_2035241_-	hypothetical protein	A0A2I6PDW7	Staphylococcus_phage	5.0e-36	100.0
AXG01411.1\|2035277_2035814_-	dUTPase	A0A0H3U2Z8	Staphylococcus_phage	7.2e-96	100.0
AXG01412.1\|2035963_2036218_-	DUF1024 family protein	A0A0H3U469	Staphylococcus_phage	5.0e-39	100.0
AXG01413.1\|2036232_2036475_-	hypothetical protein	Q4ZDP7	Staphylococcus_virus	2.1e-39	95.0
AXG01414.1\|2036478_2036847_-	hypothetical protein	A0A0H3U2T3	Staphylococcus_phage	2.0e-49	100.0
AXG01415.1\|2036859_2037264_-	RusA family crossover junction endodeoxyribonuclease	A0EWX6	Staphylococcus_phage	1.9e-72	100.0
AXG01416.1\|2037272_2037491_-	hypothetical protein	A0A2I6PDG4	Staphylococcus_phage	1.0e-37	100.0
AXG01417.1\|2037497_2038391_-	DnaD domain protein	A0A2I6PDG7	Staphylococcus_phage	5.5e-141	99.3
AXG01418.1\|2038420_2038891_-	single-stranded DNA-binding protein	A0EWX3	Staphylococcus_phage	1.3e-80	98.7
AXG01419.1\|2038891_2039509_-	MBL fold metallo-hydrolase	A0A2I6PDI9	Staphylococcus_phage	9.1e-87	100.0
AXG01420.1\|2039589_2040510_-	recombinase	A0A2I6PDH5	Staphylococcus_phage	2.3e-166	100.0
AXG02201.1\|2040511_2042455_-	ATPase	S4V9K6	Staphylococcus_phage	0.0e+00	100.0
AXG01421.1\|2042463_2042727_-	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	7.7e-43	100.0
AXG01422.1\|2042735_2042996_-	DUF1108 family protein	A0A1P8L6F5	Staphylococcus_phage	5.2e-44	100.0
AXG01423.1\|2043000_2043303_-	DUF2482 family protein	A0A1P8L6F8	Staphylococcus_phage	7.0e-48	100.0
AXG01424.1\|2043397_2043559_-	DUF1270 family protein	A0A1P8L6G0	Staphylococcus_phage	1.9e-20	100.0
AXG01425.1\|2043555_2043879_-	DUF771 domain-containing protein	A0A075LYF5	Staphylococcus_phage	3.0e-57	100.0
AXG01426.1\|2043933_2044314_+	DUF2513 domain-containing protein	Q9T1Z5	Staphylococcus_phage	3.4e-68	99.2
AXG01427.1\|2044300_2044498_-	hypothetical protein	O80075	Staphylococcus_phage	3.5e-24	87.7
AXG01428.1\|2044513_2045266_-	oxidoreductase	M9NTH5	Staphylococcus_phage	1.1e-139	100.0
AXG01429.1\|2045316_2045646_+	hypothetical protein	M9NS98	Staphylococcus_phage	2.7e-53	100.0
AXG01430.1\|2045634_2045850_-	DUF2829 domain-containing protein	A0A0H3U4C7	Staphylococcus_phage	4.8e-35	100.0
AXG01431.1\|2045865_2046129_-	XRE family transcriptional regulator	A0A2I6PF09	Staphylococcus_phage	2.1e-40	98.9
AXG01432.1\|2046125_2046299_-	transcriptional regulator	NA	NA	NA	NA
AXG01433.1\|2046261_2046975_+	XRE family transcriptional regulator	M9NUL0	Staphylococcus_phage	1.2e-130	100.0
AXG01434.1\|2046990_2047923_+	ATP-dependent helicase	A0A2I6PEZ7	Staphylococcus_phage	5.7e-173	100.0
AXG01435.1\|2047928_2048270_+	hypothetical protein	A0A2I6PF04	Staphylococcus_phage	4.6e-56	100.0
AXG01436.1\|2048473_2048656_+	hypothetical protein	M9NSW6	Staphylococcus_phage	4.1e-27	100.0
AXG01437.1\|2048755_2049220_+	hypothetical protein	A0EWV3	Staphylococcus_phage	1.1e-28	100.0
AXG01438.1\|2049278_2050316_+\|integrase	site-specific integrase	A0EWV2	Staphylococcus_phage	9.1e-180	100.0
AXG01439.1\|2051434_2052451_-	bi-component leukocidin LukGH subunit G	A0A2I6PER8	Staphylococcus_phage	5.1e-26	29.3
2051512:2051529	attR	NA	NA	NA	NA
AXG01440.1\|2052472_2053525_-	bi-component leukocidin LukGH subunit H	A0A2I6PER8	Staphylococcus_phage	2.4e-34	31.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP031131

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection