CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP022744	Streptomyces lincolnensis strain LC-G chromosome, complete genome	4 crisprs	c2c9_V-U4,cas5,cas6e,csa3,Cas14u_CAS-V,DEDDh,cas3,DinG,WYL,Cas9_archaeal,cas4	0	0	3	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP022744_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022744_1

4191463-4191524

Orphan

Consensus_repeat	Method
CCGCCGGGAGGGCCGTAGCCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022744_1

>merge|CP022744|1|4191463-4191524|CRISPRCasFinder
CCGCCGGGAGGGCCGTAGCCGCCTCCCCAGCCGTTCTGACCGCCCGGTCCACCGGGGCCGCC

>CP022744|1|1|4191463-4191524|CRISPRCasFinder
CCGCCGGGAGGGCCGTAGCCGCC	TCCCCAGCCGTTCTGA
CCGCCCGGTCCACCGGGGCCGCC

Protein	Signature genes	Signature genes Name	Protein_function
CP022744.1\|AXG54594.1\|4189612_4190431_-\|integral-membrane-protein	unknown	unknown	gnl\|CDD\|379261
CP022744.1\|AXG54589.1\|4179297_4180305_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376676
CP022744.1\|AXG54604.1\|4203342_4206180_+\|preprotein-translocase-subunit-secA	unknown	unknown	gnl\|CDD\|237259
CP022744.1\|AXG54595.1\|4190435_4191401_-\|integral-membrane-protein	unknown	unknown	gnl\|CDD\|370818
CP022744.1\|AXG54590.1\|4182496_4183489_-\|hypothetical-protein	unknown	unknown	unknown
CP022744.1\|AXG54592.1\|4187424_4188417_-\|regulatory-protein	unknown	unknown	gnl\|CDD\|223786
CP022744.1\|AXG54587.1\|4177479_4178094_+\|hypothetical-protein	unknown	unknown	unknown
CP022744.1\|AXG54605.1\|4206322_4206676_-\|hypothetical-protein	unknown	unknown	unknown
CP022744.1\|AXG54597.1\|4193138_4193816_+\|two-component-system-response-regulator	unknown	unknown	gnl\|CDD\|223816
CP022744.1\|AXG54593.1\|4188413_4189616_-\|secreted-protein	unknown	unknown	gnl\|CDD\|379527
CP022744.1\|AXG54601.1\|4200421_4201168_+\|two-component-system-response-regulator	unknown	unknown	gnl\|CDD\|225107
CP022744.1\|AXG54586.1\|4175809_4177267_+\|S-adenosyl-L-homocysteine-hydrolase	unknown	unknown	gnl\|CDD\|377487
CP022744.1\|AXG54600.1\|4199524_4200217_+\|sigma-54-modulation-protein-/-SSU-ribosomal-protein-S30P	unknown	unknown	gnl\|CDD\|238308
CP022744.1\|AXG54599.1\|4196047_4197781_+\|lipoprotein	unknown	unknown	gnl\|CDD\|237447
CP022744.1\|AXG54591.1\|4186114_4187425_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224635
CP022744.1\|AXG54598.1\|4193817_4195962_+\|two-component-system-histidine-kinase	unknown	unknown	gnl\|CDD\|223715
CP022744.1\|AXG54602.1\|4201208_4202381_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225755
CP022744.1\|AXG54603.1\|4202490_4203072_-\|acetyltransferase	unknown	unknown	gnl\|CDD\|379112
CP022744.1\|AXG54588.1\|4178135_4179167_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224628
CP022744.1\|AXG54596.1\|4191973_4193122_+\|initiation-factor-eIF-2B-alpha-subunit	unknown	unknown	gnl\|CDD\|273112

Protein	Function_ID	Function_description	E-value
CP022744.1\|AXG54594.1\|4189612_4190431_-\|integral-membrane-protein	gnl\|CDD\|379261	pfam13559, DUF4129, Domain of unknown function (DUF4129). This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.	2.83996e-06
CP022744.1\|AXG54589.1\|4179297_4180305_+\|hypothetical-protein	gnl\|CDD\|376676	pfam01944, SpoIIM, Stage II sporulation protein M. SpoIIM is on e of four stage II sporulation proteins that is necessary for the forespore inside the mother-cell to be properly internalized through the breakdown of peptidoglycans trapped between the membranes of the septum separating the forespore and the mother-cell. The four proteins working in sequence are SpoIIB, pfam05036, SpoIIM, SpoIIP, pfam07454, and finally SpoIID, pfam08486. D, M and P are in a complex with each other and the complex assembles in a hierarchical manner such that M, which serves as a membrane anchor, recruits P to the septum and P, in turn, recruits D to the septum.	5.76256e-44
CP022744.1\|AXG54604.1\|4203342_4206180_+\|preprotein-translocase-subunit-secA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
CP022744.1\|AXG54595.1\|4190435_4191401_-\|integral-membrane-protein	gnl\|CDD\|370818	pfam10110, GPDPase_memb, Membrane domain of glycerophosphoryl diester phosphodiesterase. Members of this family comprise the membrane domain of the prokaryotic enzyme glycerophosphoryl diester phosphodiesterase.	0.000697473
CP022744.1\|AXG54592.1\|4187424_4188417_-\|regulatory-protein	gnl\|CDD\|223786	COG0714, COG0714, MoxR-like ATPases [General function prediction only].	2.52307e-102
CP022744.1\|AXG54601.1\|4200421_4201168_+\|two-component-system-response-regulator	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	5.60502e-78
CP022744.1\|AXG54597.1\|4193138_4193816_+\|two-component-system-response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	8.31167e-88
CP022744.1\|AXG54593.1\|4188413_4189616_-\|secreted-protein	gnl\|CDD\|379527	pfam14258, DUF4350, Domain of unknown function (DUF4350). This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length.	5.0334e-08
CP022744.1\|AXG54586.1\|4175809_4177267_+\|S-adenosyl-L-homocysteine-hydrolase	gnl\|CDD\|377487	pfam05221, AdoHcyase, S-adenosyl-L-homocysteine hydrolase.	0
CP022744.1\|AXG54600.1\|4199524_4200217_+\|sigma-54-modulation-protein-/-SSU-ribosomal-protein-S30P	gnl\|CDD\|238308	cd00552, RaiA, RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site. RaiA is also thought to counteract miscoding at the A site thus reducing translation errors. The RaiA fold structurally resembles the double-stranded RNA-binding domain (dsRBD).	7.47295e-26
CP022744.1\|AXG54599.1\|4196047_4197781_+\|lipoprotein	gnl\|CDD\|237447	PRK13613, PRK13613, lipoprotein LpqB; Provisional.	0
CP022744.1\|AXG54591.1\|4186114_4187425_-\|hypothetical-protein	gnl\|CDD\|224635	COG1721, COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only].	1.52883e-49
CP022744.1\|AXG54598.1\|4193817_4195962_+\|two-component-system-histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	1.19861e-57
CP022744.1\|AXG54602.1\|4201208_4202381_-\|hypothetical-protein	gnl\|CDD\|225755	COG3214, COG3214, Uncharacterized protein conserved in bacteria [Function unknown].	1.47887e-74
CP022744.1\|AXG54603.1\|4202490_4203072_-\|acetyltransferase	gnl\|CDD\|379112	pfam13302, Acetyltransf_3, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	6.03732e-28
CP022744.1\|AXG54588.1\|4178135_4179167_-\|hypothetical-protein	gnl\|CDD\|224628	COG1714, COG1714, Predicted membrane protein/domain [Function unknown].	5.96156e-18
CP022744.1\|AXG54596.1\|4191973_4193122_+\|initiation-factor-eIF-2B-alpha-subunit	gnl\|CDD\|273112	TIGR00512, methylthioribose-1-phosphate_isomerase_predicted, S-methyl-5-thioribose-1-phosphate isomerase. The delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA. [Amino acid biosynthesis, Aspartate family].	3.09502e-123

>CP022744.1|AXG54595.1|4190435_4191401_-|integral-membrane-protein
MIPLRPLGVGEILDGAVSTMRTHWRTVLGISLTVAVLTEVVAILLQGFVLNDSADTEALNDPSATLDELSRAMGDAALSSAVLFVISLVGTVAATALLTTVTSRAVLGKSVTAAEAWRDARPQVLKLLGLILLLLLITVGVVFAGAVPGILVIVSGETTGGVVLAFLGMLGTGILALWLAVRYSLASPALMLEKQSITKSMSRSAKLVRGSWWRVFGIQLLATIIANIVAAIVVIPFTFLAAALGGDGIGGFLNGTGDLGWTFLVVSGIGSVIGSMITFPITAGVTVLLYIDQRIRREALDLDLARAAGVQGYGTAPTPGS
>CP022744.1|AXG54594.1|4189612_4190431_-|integral-membrane-protein
MSLAGGVLTAVPALPHAAESAVRIVLRAGDASVRAVLRAADTVSVLSLARSDDAPPLTTPRDPAREAARRELTKRMYHENDPSLLQRALDAFWDWVGKLLGSASAATPGGPLGLVVVILIVIAVLGALWWRLGAPRREPTSAPALFDDRPRSAAEHRAAAEAHAAQGHWNQAVQERMRAIVRSLEERALLDTRPGRTADEAATEAGRTLPPQSDRLRTAARDFDDVTYGGRRASEQSYHRIAELDRDLERTKPQLANSSHSTAPNTRQGAAE
>CP022744.1|AXG54593.1|4188413_4189616_-|secreted-protein
MTTEATLPSTSASPTARQVWTRARGVVLALVVLLAAAVAIAAIRSDARHGELDPRSADPYGSRAVAELLADRGVSTRVVTTLDEARAAAGPDTTLLVAVPDLLTERQQGRLYSATAESAGRTVLVAPGGTSVERLAPGIVAAPATSLDSTLSPGCDLAAARRAGTADTGGIRYTVTRPGADECYPSERLATLVRLPAESGNGDTVVLGAPDILFNNHLDEQGNASLALQLLGSRPHLVWYLPSLSDASAADPDDEKGFFDLLPSGWLWGTLQLFIAAGLAAFWRARRLGPLVPEKLPVAIRASESVEGRARLYRKANARDRAAAALRSTTRTRLAPLVGVPVTQAHAPEALLPALSAHLHTPGDGQTMHALLFGPPPSDDAALISLADQLDALEREVRRP
>CP022744.1|AXG54592.1|4187424_4188417_-|regulatory-protein
MMDPTTDNAGNTGDADTARASLEALRAEIAKAVVGQDPAVTGLVVALLCRGHVLLEGVPGVAKTLLVRALASALELDTKRVQFTPDLMPSDVTGSLVYDARTAEFSFQPGPVFTNLLLADEINRTPPKTQSSLLEAMEERQVTVDGTPRPLPDPFLVAATQNPVEYEGTYPLPEAQLDRFLLKLTIPLPSRQDEIDVLTRHAEGFNPRDLHAAGVRPVAGPADLEAARAAVAKTTVSPEITAYVVDICRATRESPSLSLGVSPRGATALLATARAWAWLTGRDYVTPDDVKALALPTLRHRVQLRPEAEMEGVTPDSVINAILAHVPVPR
>CP022744.1|AXG54591.1|4186114_4187425_-|hypothetical-protein
MALTGRAALLAALGSLPVGIWDPSWTGILAVNAPLALACACDAALAAPVRRLGLTRSGDTSVRLGDTADVTLTVTNTSRRPLRAHLRDAWPPSSWQPGTEVEASRHHLTVPPGERRRTTTRLRPTRRGDRQADRVTIRSYGPLGLFSRQGTHKVPWTVRVLPPFTSRKHLPSKLARLRELDGRTSVLTRGEGTEFDSLREYVPGDDTRSIDWRATARQTTVAVRTWRPERDRHILLVLDTGRTSAGRVGDAPRLDASMDAALLLAALASRAGDRVDLLAYDRRVRALVQGRTAGDVLPSLVNAMASLEPELVETDSRGLTATALRSAPRRSLIVLLTSLDAAPVEEGLLPVLPQLTQRHTVLLASVADPHIARMARARGNSDAVYEAAAAAQAQSERHRTAEQLRRHGVTVVDATPDDLAPALADAYLALKSAGRL
>CP022744.1|AXG54590.1|4182496_4183489_-|hypothetical-protein
MSALLYRPIRTRFRYGFPTRVNLATHRKLAGSFFKRHAVTTACASTYSDAPTACRHTVSGTISLRSRGTFHHSLTVLSAIGHQGIFRLSGWSRQIHTGFLGPRATWVSLKRAADVSTTGVLPSTPDLSHVLRLHQRFLTRPVAGRRQKRDPTTPHTQPLPGLTRIRFGLIRFRSPLLPESRLFSLPAGTEMFHFPAFPPHTLCVQVWVTAHDDCRVSPFGNPRIKAWLTTPRGLSWPPTSFIGSWCQGIHRAPLKTWPQMLASTVQFSNNDQPPITPPSWASSLGPAPEDRTLRPCPQTPNSVPDTLSASLNVPRSEEQYWKEKTIKCAE
>CP022744.1|AXG54589.1|4179297_4180305_+|hypothetical-protein
MDLDVFVTAHRAEWDRLDALLRRQRRLTGTEVDELVALYQRTATHLSLIQSSAPDPQLTGRLSQLVARARSAVTGTRRASWRDVTRFLTHGFPAAVYRSRHWWVPTALLSTVVAALLGWWIGAHPDVQATIAAPDELRELTRPGGQYETYYSSHPAASFAAQVWTNNAQAAAMCLVLGIFLGLPVLWILFQNMLNLGVGFGLMSSAGRLDTFLGLILPHGLLELTAVFVAAGTGLRLGWTVIDPGPRSRRSALAEEGRAAVGMAIGLALVLFISGAIEGFVTPSGLPTWARIGIGILAELAFLAYVYVLGGRAVRAGDTGDVEEAERSAAVPTAA
>CP022744.1|AXG54588.1|4178135_4179167_-|hypothetical-protein
MSELVTGEAVALELRPARLPSRALAVLIDLAVTITAYVVVTIVLVASTSSLDDAAQIALSIAAFLLVLVGGPIAVETLSHGRSLGKLACGLRVVRDDGGPIRFRHALVRGAIGTVEILMTFGVVATIASLVSARGRRLGDVFAGTLVVRERIPTARAGVVPPPPPWLAGRFSGLDLSAVPDGLWLAIRQYLTRMHQLDPRVGWTMAERLAGDLAARTGAPAPQGVPPAAYLAAVMQERQAREARRAFGGGAGGATAAGAPRGYGGPSNGAPGGYEPPSGGSAGVPQATGQDVAGVSPAVSPVGGSAEAPVDGRFGAPVPEAQPAVPRSTPSAERPGTGFVPPA
>CP022744.1|AXG54587.1|4177479_4178094_+|hypothetical-protein
MPRGRYSLHDPHDHTPLAEEHFQCAPGPSGWRYVSQLTAPSGEHSGSVDLTLDELGRPLRLELHAASWQVRGAALDGVTWVRTDPSGTHATEGNVAAHAFTGTSPAFLIATTRLLRLTPSGPATRVRLVVFTDPVLAPRTVDQSWALLKREAHATDNGPLTVEEYQVTALDTGEQHTVHIAGDVVLAAPGIELENLDSPPSVFT
>CP022744.1|AXG54586.1|4175809_4177267_+|S-adenosyl-L-homocysteine-hydrolase
MTTVENRHDFKVADLSLAEFGRKEITLAEHEMPGLMAIRKEYAEAQPLAGARVTGSLHMTVQTAVLIETLAALGAEVRWASCNIFSTQDHAAAAIAVGPNGTPDNPQGIPVFAWKGETLEEYWWCTEQALTWPNTPTGGPNMILDDGGDATMLVHKGVEYEKDGKVPDVETAESDEHRVVLELLTRTVAESPQKWTQVASEIRGVTEETTTGVHRLYEMQRDGTLLFPAINVNDAVTKSKFDNKYGCRHSLIDGINRATDVLIGGKTAVVFGYGDVGKGCAESLRGQGARVIVTEIDPICALQAAMDGYQVTTLDEVVDKADIFITTTGNKDIIMASDMAKMKHQAIIGNIGHFDNEIDMAGLAKIPGVVKDEVKPQVHTWKFPDGKVLIVLSEGRLLNLGNATGHPSFVMSNSFADQTLAQIELFTKPDEYPTGVYVLPKHLDEKVARLHLDALGVKLTQLRPEQAAYIGVEVDGPFKPDHYRY
>CP022744.1|AXG54596.1|4191973_4193122_+|initiation-factor-eIF-2B-alpha-subunit
MADQYAQTGEDSRPTEIPAIRWEEPPEGPVLVLLDQTRLPAEEVELVCTDASALVEAIRSLAVRGAPLLGIAGAYGVALAAARGFDVDDAANSLAGARPTAVNLAVGVRRARAAFQAELGKGGDARQAAEAALAAARKLHREDAEASARMAERGLALLDELLPGGGHRILTHCNTGSLVSGGEGTAFAVALAAHRVGRLRRLWVDETRPLLQGARLTAYEAARSGMAYTLLTDNAAGSLFAAGEVDAVLIGADRIAADGSVANKVGSYPLAVLARYHHVPFIVVAPVTTIDLDTPDGASIEVEQRPGHEVTEVTAPQVPVAGAEAGGGIPVAPLGTQAYNPAFDVTPPELVTAIVTEEGAVSPVTAEALAELCARSRQVTIS
>CP022744.1|AXG54597.1|4193138_4193816_+|two-component-system-response-regulator
MKGRVLVVDDDTALAEMLGIVLRGEGFEPSFVADGDKALAAFRESKPDLVLLDLMLPGRDGIEVCRLIRAESGVPIVMLTAKSDTVDVVVGLESGADDYIVKPFKPKELVARIRARLRRSEEPAPEQLAIGDLVIDVAGHSVKRDGQSIALTPLEFDLLVALARKPWQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRSKVEKDPERPEIVVTVRGVGYKAGPS
>CP022744.1|AXG54598.1|4193817_4195962_+|two-component-system-histidine-kinase
MSGDSAASSPGRTGARAERPVGRKKAGSRWGRFLEGGLLQGGVQGSPVLRLFMRWVRRPLLPVMRLWRRNIQLKVVVTTLLMSLGVVLLLGFVVIGQVRNGLLDAKVKASQSQATGGFAVAKQKAEEAGTGAGDDGAPVDEHTEQNVIQWMSDLVESLSSGGQGAFDVVTLPAAGDASGGGRGPRASGDVDWSASVPEALRERVDSSTAAAQSYTRIVYDDTAGKEAQPGLVIGKQVNDPNDDPYQLYYLFPLTQEEKSLSLVKGTLATAGLFVVVLLGAIAWLVVRQVVTPVRMAAGIAERLSAGRLQERMKVTGEDDIARLGEAFNKMAQNLQLKIQQLEDLSRMQRRFVSDVSHELRTPLTTVRMAADVIHEAREDFDPVTARSAELLADQLDRFESLLADLLEISRFDAGAAALEAEPIDLREVVRRVLSGAAPLAERKGTHIRVVGDQQPVVAEADARRVERVLRNLVVNAVEHGEGKDVVVKLAAAGGAVAVAVRDYGVGLKPGEATRVFSRFWRADPARARTTGGTGLGLSIALEDARLHGGWLQAWGEPGGGSQFRLTLPRTADEPLRGSPIPLEPKDSRRNRGLDDAGLPRGNAEKAATVPAQPSRDPVTSRDPIAPRPTGMAATADPTALPGNGARVVPRPASGVRRQDDTSVGDAPRGGPEGSAGTGPEAPHGHPEEPHEQAQAQASYGQEDSHSQGEAFRGR
>CP022744.1|AXG54599.1|4196047_4197781_+|lipoprotein
MPDSGDLRGVDSTPRQDTQVRVFAMPPQEDATSGEIVQGFLEALTSDDPKYETARKYLTNEAAKSWHPELSTTVLAEAPDMDPRRSGGREDTADDLYTLTGTKVATVDAQQSYEPADGSYDQSVHLVRDPKTKQWRIDGPPPGVVMGKSDFQRNYLSVDKYYFADYPVSGTSPTTVAVADPVYVRERVNPMTQMVRSLLNGPTTWLEPVAGSSFPTGVRLQDDGASLTPDDQNKLTVPLNDRAARVGVSVCHRMAAQVLFTLQDLTPAVDEVELRAGGKQLCSLKEDDAPAVATRGSVQQPEYLYFVDARKRLVRMAADSSGTQHDPVPGALGDGDKALQSVAVSRDEHKAAGVATDGKELYVASLAAAGSLGDAVLTSKGATANDRLTTPSWDAQGDLWVADRDPRDPRLVVLEDGGGDPFTVDIPGLEGRIKDVRVAADGVRIALVVEKGGKQSLLIGRIERSEKSERPAVAVRELRSAAPELEEVAAMSWAGDSRLVVVGRERGGVQQTRYVQVDGSTPEGPAPAALTGVKEIAASEDDQMPLVAYSEDGIVRLRTGTQWEKVDAEGTAPVYPG
>CP022744.1|AXG54600.1|4199524_4200217_+|sigma-54-modulation-protein-/-SSU-ribosomal-protein-S30P
MDIVVKGRKTEVPERFRKHVAEKLKLEKIQKLDGKVISLDVEVSKEPNPRQADRCDRVEITLRSRGPVIRAEAAASDPYAALDLAAEKLDARLRKQHDKRHTRRGARRLTAAEVPDHVPGAATLNGNGHTVREEEPDGVPTKKIGSLEIKGEGPLVVREKTHVASPMTLDQALYEMELVGHDFYLFIDSETKEPSVVYRRHAYDYGVIHLSTDPMVTQAQPPAAGGTLGG
>CP022744.1|AXG54601.1|4200421_4201168_+|two-component-system-response-regulator
MADSFGPMQDEDAGDGAVGMGPDEGSPRKEPIRVLVVDDHALFRRGLEIVLAAEEDIQVVGEAGDGAEAVDKAADLLPDIVLMDVRMPKRGGIEACTSIKEVAPSAKIIMLTISDEEADLYDAIKAGATGYLLKEISTDEVATAIRAVADGQSQISPSMASKLLTEFKSMIQRTDERRLVPAPRLTDRELEVLKLVATGMNNRDIAKELFISENTVKNHVRNILEKLQLHSRMEAVVYAMREKILEIR
>CP022744.1|AXG54602.1|4201208_4202381_-|hypothetical-protein
MTTPPPTIQLSADEARRIVLRAQGFLGAPDRKAGVRGILRHLGAVQLDTISVLARSHELIPYARLGAVDRRTVEKAYWTDTHAFEYWSHAACILPIEEWPHFAFRRRSYRSRPHWNHQLPDGVYDQVIKQLRAEGPLTATELGGAKRTSEWWDWSGTKVAVERALMYGEVVCVERRGWKRVYDLAERAVPDSLLHDDLDDTECLRRLVRLAGQSLGVGTRADIADYHRLKGEQVDAVIADSGLVPVTVEGWGKPAWADPAALETPPRGRHRTTLLSPFDSLIWERARTERVFGFTHRLEAYVPKPKRVYGYFAMPVLAGGHLVGRVDPAREGRTLVAKQVTLDGPKAVPAVAQALVEAASWVNCTDVRVEKVAAPELREALAREVTRATP
>CP022744.1|AXG54603.1|4202490_4203072_-|acetyltransferase
MDPVTLTTGRLLLRTVGPQDTDVVYAAAQDPEIQRWTTIPVPYLPEHARSFTDQLVPEGWANGSMLTWGLFLPEGEELVGMLSLTMRTLGAAEVGFWSAGRHRGRGYVTEAVLAVARWAFTDLSLDRVEWRAEVGNTASRAVAERAGFVIEGVMRSAIIHRGARRDCWVGALLPSDLALPSTAPYLPAPVQPA
>CP022744.1|AXG54604.1|4203342_4206180_+|preprotein-translocase-subunit-secA
MSVLSKIMRAGEGKILRKLHRIADQVNSIEEDFVDLSDAELRALTEEYKQRYADGETLDDLLPEAFATVREAAKRVLGQRHYDVQIMGGAALHLGYVAEMKTGEGKTLVGTLPAYLNALSGKGVHLITVNDYLAERDSEMMGRVHKFLGLEVGCILANMTPSQRREQYACDITYGTNNEFGFDYLRDNMAWSHDELVQRGHNFAIVDEVDSILVDEARTPLIISGPADQATKWYGDFAKLVTRLKRGEAGNPLKGVEETGDYDVDEKKRTVAIHESGVSKVEDWLGIDNLYESVNTPLVGYLNNAIKAKELFKKDKDYVVMDGEVMIVDEHTGRILAGRRYNEGMHQAIEAKEGVDIKDENQTLATITLQNFFRLYKRHDHNDKEQPGLCGMTGTAMTEAAEFHQIYKLGVVPIPTNRPMIRKDQSDLIYRTEVAKFEAVVDDIAEKHEKGQPILVGTTSVEKSEYLSQQLSKRGIQHEVLNAKQHDREATIVAQAGRKGAVTVATNMAGRGTDIKLGGNPEDLAEAELRQRGLDPEEHIEEWAAALPAALKNAEQAVKTEFEEVKDLGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDDLMRLFKAQMVERVMSMANVPDDVPIENKMVTRAIASAQSQVEQQNFETRKNVLKYDEVLNRQREVIYGERRRVLKGEDLHEQVQHFMDDTIDAYVGAETAEGFPEDWDLDRLWGAFKQLYPVKVTVEELEEAAGDRAGLTAEFISESIKDDIHDQYAEREAQLGSEIMRELERRVVLSVLDRKWREHLYEMDYLQEGIGLRAMAQKDPLVEYQREGFDMFTAMMEGIKEESVGYLFNLEVQVEQQVEEVPVEDAKPSLDKQDAVPAQAGARPEIRAKGLDVPQRRELHFSAPTVDGEGGVVEGDFAEDEPVRSESDGLTRAERRKQSRGGRRRKK
>CP022744.1|AXG54605.1|4206322_4206676_-|hypothetical-protein
MVPQPRPTDRFADLLLAVLSGRRPVHCMLRHTAGRAYDELAWLAERGPLRTTRGTMPVVRDIGYEVTRPGAIEAFARIGAGDQLRAMAFRLEQGPDLRWRCTAVELGGPRRPHADDG

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Crispr_ID: CP022744_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022744_3

7625791-7625906

Orphan

Consensus_repeat	Method
TCATCGACCGGCCTCCTGCGTGGTGTTGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022744_3

>merge|CP022744|3|7625791-7625906|CRISPRCasFinder
TCATCGACCGGCCTCCTGCGTGGTGTTGAGACTGTGCTTTCCCGGGGGATAACCCCCGGGCCCCCAGCCGAGTGTGTACTCGACGTTCATCGACCGGCCTCCTGCGTGGTGTTGAG

>CP022744|3|3|7625791-7625906|CRISPRCasFinder
TCATCGACCGGCCTCCTGCGTGGTGTTGAG	ACTGTGCTTTCCCGGGGGATAACCCCCGGGCCCCCAGCCGAGTGTGTACTCGACGT
TCATCGACCGGCCTCCTGCGTGGTGTTGAG

Protein	Signature genes	Signature genes Name	Protein_function
CP022744.1\|AXG57483.1\|7621608_7621833_-\|hypothetical-protein	unknown	unknown	unknown
CP022744.1\|AXG57485.1\|7622725_7623004_+\|transglycosylase-associated-protein	unknown	unknown	gnl\|CDD\|182475
CP022744.1\|AXG57484.1\|7622059_7622479_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378630
CP022744.1\|AXG57496.1\|7632969_7634196_-\|3-phosphoserine-phosphatase	unknown	unknown	gnl\|CDD\|319803
CP022744.1\|AXG57486.1\|7623066_7624335_-\|tyrosyl-tRNA-synthetase	unknown	unknown	gnl\|CDD\|235645
CP022744.1\|AXG57493.1\|7630389_7631763_+\|transmembrane-transport-protein	unknown	unknown	gnl\|CDD\|129974
CP022744.1\|AXG57490.1\|7628359_7629127_+\|enoyl-(acyl-carrier-protein)-reductase	unknown	unknown	gnl\|CDD\|236124
CP022744.1\|AXG57492.1\|7629620_7630316_-\|GntR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|225097
CP022744.1\|AXG57481.1\|7618868_7620497_+\|transmembrane-transport-protein	unknown	unknown	gnl\|CDD\|271374
CP022744.1\|AXG57482.1\|7620636_7621626_+\|molybdenum-cofactor-biosynthesis-protein-A	unknown	unknown	gnl\|CDD\|234672
CP022744.1\|AXG57478.1\|7615042_7616611_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173799
CP022744.1\|AXG57495.1\|7632439_7632895_+\|phosphohistidine-phosphatase	unknown	unknown	gnl\|CDD\|224973
CP022744.1\|AXG57497.1\|7634376_7636392_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
CP022744.1\|AXG57480.1\|7618515_7618872_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377315
CP022744.1\|AXG57498.1\|7636631_7639166_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
CP022744.1\|AXG57479.1\|7616708_7618238_-\|subtilisin-like-protease	unknown	unknown	gnl\|CDD\|173810
CP022744.1\|AXG57494.1\|7632104_7632311_+\|hypothetical-protein	unknown	unknown	unknown
CP022744.1\|AXG57477.1\|7613589_7614954_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367110
CP022744.1\|AXG57489.1\|7627619_7628354_+\|3-oxacyl-(ACP)-reductase	unknown	unknown	gnl\|CDD\|273824
CP022744.1\|AXG57491.1\|7629292_7629646_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP022744.1\|AXG57485.1\|7622725_7623004_+\|transglycosylase-associated-protein	gnl\|CDD\|182475	PRK10457, PRK10457, hypothetical protein; Provisional.	1.33568e-06
CP022744.1\|AXG57484.1\|7622059_7622479_-\|hypothetical-protein	gnl\|CDD\|378630	pfam11298, DUF3099, Protein of unknown function (DUF3099). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	8.01716e-20
CP022744.1\|AXG57486.1\|7623066_7624335_-\|tyrosyl-tRNA-synthetase	gnl\|CDD\|235645	PRK05912, PRK05912, tyrosyl-tRNA synthetase; Validated.	0
CP022744.1\|AXG57493.1\|7630389_7631763_+\|transmembrane-transport-protein	gnl\|CDD\|129974	TIGR00896, Inner_membrane_transport_protein_YeaN, cyanate transporter. This family of proteins is involved in active transport of cyanate. The cyanate transporter in E.Coli is used to transport cyanate into the cell so it can be metabolized into ammonia and bicarbonate. This process is used to overcome the toxicity of environmental cyanate. [Transport and binding proteins, Other].	2.34208e-123
CP022744.1\|AXG57490.1\|7628359_7629127_+\|enoyl-(acyl-carrier-protein)-reductase	gnl\|CDD\|236124	PRK07889, PRK07889, enoyl-[acyl-carrier-protein] reductase FabI.	3.23068e-172
CP022744.1\|AXG57492.1\|7629620_7630316_-\|GntR-family-transcriptional-regulator	gnl\|CDD\|225097	COG2186, FadR, Transcriptional regulators [Transcription].	2.44515e-51
CP022744.1\|AXG57481.1\|7618868_7620497_+\|transmembrane-transport-protein	gnl\|CDD\|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
CP022744.1\|AXG57482.1\|7620636_7621626_+\|molybdenum-cofactor-biosynthesis-protein-A	gnl\|CDD\|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	2.82936e-180
CP022744.1\|AXG57478.1\|7615042_7616611_-\|hypothetical-protein	gnl\|CDD\|173799	cd07473, Peptidases_S8_Subtilisin_like, Peptidase S8 family domain in Subtilisin-like proteins. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	1.2079e-51
CP022744.1\|AXG57495.1\|7632439_7632895_+\|phosphohistidine-phosphatase	gnl\|CDD\|224973	COG2062, SixA, Phosphohistidine phosphatase SixA [Signal transduction mechanisms].	6.86949e-37
CP022744.1\|AXG57497.1\|7634376_7636392_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	3.71419e-07
CP022744.1\|AXG57480.1\|7618515_7618872_+\|hypothetical-protein	gnl\|CDD\|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	1.3655e-33
CP022744.1\|AXG57498.1\|7636631_7639166_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.82222e-74
CP022744.1\|AXG57479.1\|7616708_7618238_-\|subtilisin-like-protease	gnl\|CDD\|173810	cd07484, Peptidases_S8_Thermitase_like, Peptidase S8 family domain in Thermitase-like proteins. Thermitase is a non-specific, trypsin-related serine protease with a very high specific activity. It contains a subtilisin like domain. The tertiary structure of thermitase is similar to that of subtilisin BPN'. It contains a Asp/His/Ser catalytic triad. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) clan include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53 the it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values.	4.80957e-54
CP022744.1\|AXG57477.1\|7613589_7614954_-\|hypothetical-protein	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	9.76583e-43
CP022744.1\|AXG57489.1\|7627619_7628354_+\|3-oxacyl-(ACP)-reductase	gnl\|CDD\|273824	TIGR01830, 3-oxoacyl-_reductase_FabG, 3-oxoacyl-(acyl-carrier-protein) reductase. This model represents 3-oxoacyl-[ACP] reductase, also called 3-ketoacyl-acyl carrier protein reductase, an enzyme of fatty acid biosynthesis. [Fatty acid and phospholipid metabolism, Biosynthesis].	2.12467e-123
CP022744.1\|AXG57496.1\|7632969_7634196_-\|3-phosphoserine-phosphatase	gnl\|CDD\|319803	cd07500, HAD_PSP, phosphoserine phosphatase (PSP), similar to Methanococcus Jannaschii PSP and Saccharomyces cerevisiae SER2p. This family includes Methanococcus jannaschii PSP, and Saccharomyces cerevisiae phosphoserine phosphatase SER2p, EC 3.1.3.3, which participates in a pathway whereby serine and glycine are synthesized from the glycolytic intermediate 3-phosphoglycerate; phosphoserine phosphatase catalyzes the hydrolysis of phospho-L-serine to L-serine and inorganic phosphate, the third reaction in this pathway. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.18441e-93

>CP022744.1|AXG57486.1|7623066_7624335_-|tyrosyl-tRNA-synthetase
MTDIVDELKWRGLWALSTDEDALRKALADGPVTFYCGFDPTAASLHVGHLVQVLTMRRLQQAGLRPLALVGGATGQIGDPRPTAERTLNDPETVANWVGRLRAQIEPFLSFEGENAATMVNNLDWTAGMSAIEFLRDIGKHFRVNKMLTKDSVARRLESQEGISYTEFSYQLLQGMDFLELYRRYGCTLQQGGSDQWGNLTAGLDLIHRLEPEASAHCLATPLMVKADGTKFGKTEGGAVWLDPEMTTPYAFYQFWLNVDDRDISTYMRILSFRSREELEELEQQTQERPQARAAQRALAEELTTLVHGAGQTAAVIAASRALFGQGDLAELDEKTLTAALSEVPHVRVPQLGPVVDLFAEVGLVASKSAARRTVKEGGAYVNNAKVTAEDAVASQEELLHGRWLVLRRGKKNLAAVEVTGA
>CP022744.1|AXG57485.1|7622725_7623004_+|transglycosylase-associated-protein
MGWLWAIIVGLVLGLIAKAIIPGKQHSPLWLTTIFGMLGAIVGNAIARWAGVDSTSGIDWSRHAFQLVAAVVIVAVGDMLYMATLGKRKQRT
>CP022744.1|AXG57484.1|7622059_7622479_-|hypothetical-protein
MRKQHDGGNAQVFRITGARTGLQEDVRGRQRRYVISMTVRTIAVILAATLWDVERHVAIVALVLGMVLPYVAVVVANAGRENAPSLPSTFVTAPTPPMILPPRAEEGDGTPREGFAEPGPEDVPADPAPGARSEPHERA
>CP022744.1|AXG57483.1|7621608_7621833_-|hypothetical-protein
MSDTPICSAKGCRADAVWVLAWNNPKIHTPERRKTWLACEEHREHLSQFLGVRGFLKDVVLLKEWEEGSSATDG
>CP022744.1|AXG57482.1|7620636_7621626_+|molybdenum-cofactor-biosynthesis-protein-A
MLIDTYGRVATDLRVSLTDRCNLRCTYCMPEEGLQWLAKPDLLTDDEIVRLIDIAVTTLGIEEVRFTGGEPLLRPGLVGIVERVAALDPRPQMSLTTNGIGLKRTASALKAAGLDRVNVSLDTLRPDVFKTLTRRDRHQDVIAGLEAARDAGLTPVKVNSVLMPGLNDDEAPDLLAWAVEHDYELRFIEQMPLDAQHGWKRDGMITAGDILTSLRTRFELTEEGSDKRGSAPAERWIVDGGPHVVGVIASVTRPFCAACDRTRLTADGQIRTCLFAREETDLRAALRSGAPDEEIARIWRLAMWGKKAGAGLDDPTFVQPDRPMSAIGG
>CP022744.1|AXG57481.1|7618868_7620497_+|transmembrane-transport-protein
MSPAMSHVQLAANEASEHRPLIITLFALFVVATLFITVWAGRQTKDAADFYAGGRSFSAFQNGLAVSGDYMSAASFLGIAGAIALFGYDGFLYSIGFLVAWLVALLLVAEPLRNSGRYTMGDVLAYRMRQRPVRTAAGTSTIVVSIFYLLAQMAGAGVLVSLLLGITTDAGKILIVALVGVLMIVYVSIGGMKGTTWVQMVKAVLLIGGTILITFLVLLKFNFNISDLLGKAAENSGKGAAFLEPGLQYGATGTSKLDFISLGVALVLGTAGLPHILIRFYTVPNAKAARKSVNWAIGIIGGFYLMTIALGFGAAALISQDEIIASNPSGNTAAPLLALHLGGVDSAWGAILLATISAVAFATILAVVAGLTLASSSSFAHDIYANVIRKGQATEKEEVRAARLATIGIGAVSILLGALARDLNVAGLVALAFAVAASANLPTILYSLFWKRFTTQGALWSIYGGLIVAVGLVLFSPVVSGDPKAMFPDVDFAWFPLKNPGIISIPFGFLMGWLGTVLSKEEPDVKKFAELEVRSLTGTGAH
>CP022744.1|AXG57480.1|7618515_7618872_+|hypothetical-protein
MATDAPPPSKEQHKLPSPEEFTEVHESAEFRELRRSYHSFAFPLTVGFIAWYLLYVLLSNYAGDFMGTKVVGNINVAFVLGIAQFVTTFLIAWWYSRHAAAKLDPKAEAIKSRMEGGA
>CP022744.1|AXG57479.1|7616708_7618238_-|subtilisin-like-protease
MPHLRSRSRLALAVPVVLSLTASLGFLPAAAAAAPSTPSAAQTADAPALAYVVNTKADRRVIASVKRAVAAAGGTVVTTYDRIGVIVVHSSNPDFAKAMRAVRGVQSAGATRTTPLTAAGTTDEGAAQFLSKAQAAKAANASAAVPESEPLEADQWDLRAIGADKAAKINPGSRKVTVAVIDTGVDDTHPDLAPNFSASQSANCVGGVADTAAGAWRPYTPEDYHGTHVAGEIAAARNGIGVAGVAPGVKVAGIKVSDPDNGLFYPESVVCAFVFAADHGVEITNNSYYVDPWLYNCMDDPDQKAIVDAVNRAQLYAQRKGTLNLASAGNSNHDLDSDAIVDTTSPDDSTPVTRTIDPHECFDVPTQLPGVVTVSATGVQNLKSYYSTYGKGVVDVAAPGGDRRYQLPDTPSKDGRILSTMPNGQYAFLQGTSMASPHAAGVAALLKSKHPFATPAQLQALLKAQADNPGCPASYDQDGDGTQDAVCEGGKRVNGFYGYGIVNALRAVK
>CP022744.1|AXG57478.1|7615042_7616611_-|hypothetical-protein
MTVVHPRFRRAITIPLGMTMATAMAFLPTATASASVLPDTVHGVTGTVNDVLASVGKADAGALSYVVNVRPGKAPSATVKKAIADAGGTIVTSYDQIGVIVVHSSNPDFAKTVRKVKGVDSAGNTRNAPLPAQSTEDLGAPKALTATELAAAEAKADAGQDPLENLQWDLPAIKADKAHEKTLGSGKVTVAVIDTGVDDTHPDIAPNFDRAASVNCVTGKPDTADGAWRPSASESPHGTHVAGEIAAAKNGVGMTGVAPGVKVSGIKVSTTAGYFYTEAVVCGFMWAATHGVDVTNNSYYTDPWYFNCTDDPDQKALVDAVSRASRYAEKKGVVNVAAAGNENYDLAADEITDPVSPNDGTPSDRVVDPSKCLDIPTQLPGVVTVASTGAKGIKSSFSNHGLGVIDVAAPGGDSTAYQTPAPPATSGLILGTLPGGKWGYMAGTSMASPHAAAVAALIKSTHPYAPPALVKALLYAEADATPCTDPYDINGDGKVDAVCEGSKNRNGFYGWGTVDALDAVTK
>CP022744.1|AXG57477.1|7613589_7614954_-|hypothetical-protein
MAWSAVGGDPALVSRVSTVVREGAWQGRLPVRALARACVGACALAAAELGARRAGLSEVPAVRVDDGAVATAFLSERHLAIDGRAPVTFAPLSRFWRTADGWVRTHANYPHHRARLLDVLGVPQDVAAVEAALAERPALEVEEAVYAAGGLAVALRTPEEWAAHEQAAALAGRPLVERELLDSAPARVLAPLDTAGAPLLPAAGLRVLDLTRVIAGPVATRTLALLGADVLRVDAPQLPELPDQHADTGFGKRSTTLDLATDRRTFEDLLAAADVVVTGYRPGALDRFGLSARSLAERRPGLVVAQLSAWGASGPWAGRRGFDSLVQVATGIAAVEGSRERPGALPAQALDHGTGYLLAAAMLRALTEQSYDGGGRVVRLALARTARWLTEGVGTEEAETAGGASYDGAAPWLAETDSPLGRLRYARSPVSFAGGPTDWTRPPGPWGADERRWL
>CP022744.1|AXG57489.1|7627619_7628354_+|3-oxacyl-(ACP)-reductase
MSDRYRKGDPLSRSVLVTGGNRGIGLAIARAFADAGDKVAITYRSGEPPSGFLAVKCDITDTEQVEQAYKEIEAEHGPVEVLIANAGVTKDQLLMRMSEEDFTSVVDTNLTGTFRVVKRANRGMLRAKKGRVVLISSVVGLYGSPGQANYAASKAALVGFARSLARELGSRNITFNVVAPGFVDTDMTKVLTDEQRAGIVSQVPLGRYAQPEEIAATVRFLASDDASYITGAVIPVDGGLGMGH
>CP022744.1|AXG57490.1|7628359_7629127_+|enoyl-(acyl-carrier-protein)-reductase
MSGILEGKRVLITGVLMESSIAFHAAKLAQEQGAEIILTAFPRPTLTERIAKKLPKPTKVIELDVSNDEHLARLADLVAEELGGLDGVVHSIGFAPQDALGGNFLNTPFESVATAMHVSAFSLKSLTMACLPLMQNGGSVVGLTFDAQYAWPQYDWMGPAKAALEATSRYMARDLGKQNIRCNLISAGPIGSMAAKSIPGFSDLAAVWDSRSPLEWDLKDPEPAGRGIVALLSDWFPKTTGEIIHVDGGLHAIGA
>CP022744.1|AXG57491.1|7629292_7629646_+|hypothetical-protein
MRLSRSLASVTAAVCLVMSLPYDAMPHARVETRRAAAPEPFGASCHSRITGSQVTAYCHNPYPRTDGVRLHIECDRWWDLDSDGAQVRAGPAQTVRLTGRCWKEIRAVWVSHRKLAR
>CP022744.1|AXG57492.1|7629620_7630316_-|GntR-family-transcriptional-regulator
MPLSHPRRSALSEQVIAALRTQITSGEWPVGARIPTEPELVEQLGVARNTVREAVRALAHNGLLDIRQGSGTYVVATSELAGVMHRRFADADPRHIAELRSTLESSAARLAAVRRTEKDLKQLDALLVRREEAWESGDTEAFVAADATFHLAVVAASHNDVMTEMYADLGEVLRDWLREDVGEELTPETHMDHARLVDAIRTGDAAAAAEEAASYPFLCRPGRFSEPASGG
>CP022744.1|AXG57493.1|7630389_7631763_+|transmembrane-transport-protein
MGLMAREETRTTQPTTVRTSATDPAVDVASDAQGDAQAAAMRAPRAWVVRLVVVAIVLSALNLRPAITSLGALLEEVRDGLGMSGGVAGLLTSMPPLCFALFGGMAPRLARRFGPSAVVCAGMLAITAGLLIRPYAGSTAGFLAASALALMGIAVSNVLMPVIVKRWFPDRVGSMTGLYSMAVALGTAAAAAVSVPMTDALGGNWQSGLALWAVLAAVAVVPWVPLLRDRGAAPDARGAASTAAKAPASSAGRTPAREEAAAPVRITRSRTAWALAVFFGLQATAAYITMGWMAQIFRDAGVPASTAGLLLAVTMVMGVPLAFVIPRLASRLPHQGPIVVALGVCGLAGYAGLYAAPAAGAWAWALLLGIANCAFPLALTMVGMRARTGVGVAQLSAFAQSTGYLISIPGPILVGVLYQSSGGWGLPIALMTGLMIPQMVVGVLAGRNRTVEDEAAR
>CP022744.1|AXG57494.1|7632104_7632311_+|hypothetical-protein
MSAPTQTPPHPASRGGVDIRLPWWALALPTLAFVVLLALILNPSDAHAATGDPAVTRLLQHLQQLIAG
>CP022744.1|AXG57495.1|7632439_7632895_+|phosphohistidine-phosphatase
MTDHERPLADRGRKEAAEAGRRLTDTGLSLDLALCSTATRTRETWKLAVQEFPHRPKTVYEERIYEASPGELIALLNETPDDAQNVVLVGHNPGIQGLADILAGSAEGDARDRMSGRGFPAAAFAVLSFSGSWKALEPGVATLLEYWAPSD
>CP022744.1|AXG57496.1|7632969_7634196_-|3-phosphoserine-phosphatase
MSASQTSIAASISDVPTLLVKIFGKDRPGITAGLFDTLAAFSVDVVDIEQVVTRGRMVLCALVTAPPRGLEGDLRSTVHSWAESVKMQAEIISGRGDNRPRGLGRSLVTVLGHPLTAEATGAVAGRITRTGGNIDRIFRLAKYPVTAVEFAVSGVETEPLRTALVTDAAKLGVDVAVVAAGLHRRAQRLIVMDVDSTLIQDEVIELFAAHAGCEAEVAEVTAAAMRGELDFEQSLHARVALLKGLDASVVDKVRSEVRLTPGARTLIRTLKRLGYQVGVVSGGFTQVTDDLKDRLGLDFAHANTLEIAEGRLTGRVTGEIVDRAGKARLLRRFAAEAGVPLAQTVAIGDGANDLDMLNAAGLGVAFNAKPVVREAAHTAVNFPFLDTVLYLLGVTREEVEAADMHDED
>CP022744.1|AXG57497.1|7634376_7636392_-|hypothetical-protein
MSVGAAKPGTRLPWGDILLSAIAAVSWALIGMAGTAALGLHLLGADTTASLGPMTAAVVALGAGGSVTPSGDVSAFGLSGAQAATAIEITPLGVGLVGALLLSWFFLRSLRTAGVVIAPSELLARAGAVIALFVAMLGGLAWAGHDVITIDGSALGLDDLPGGSGGGGVEIPGVGDIGDIGGLLPDRIGDLVDAQAAVGFTVDTAPTLLGGLGWCAGVLLIALLASRRTPLPHGWEAVHRVVRPAASALVTVLLMAVAAGFAAAAYAAIGDDNPKRIAGAALLGAPNGVWLGIPIGLFVPFDGRATGVLTNFLPDPLDRLLNSESDQSVTLGRLAELDGRVWLLGIGAAMMMLLAGVLTAVRTPVAEPARSGARPGARPGAVVRDPGAVRFAGRCALRLGVATALAMPLLAWLTEVAVDASLSVLGFNAFGAGIKLDGNLGMALLLGALWGAVAGAAGALLARATGAAGQRTAALALGDVGAGAPGRGSGWSAEGAGEGGLGAGGVGGAVGPGYGGGAGVGPPGGGARGSQSGPYSSGSSYRPPNPATNPYLRMPEGIVREPEDARPPGAEQARGGAGSSGEARSASRDARSAEEASSWPDVSQSPGDGMYGAPTVARPVDPPPRSPHGPGRMPEEDGPSSGSNQPAKRRRPPPPPPSPPPPAPRGPKGRR
>CP022744.1|AXG57498.1|7636631_7639166_+|ABC-transporter-ATP-binding-protein
MGHGVPELVLESNGRTWTLDPSRSYTLGRDPQGDVVLDDARVSWRHATISFNGRSWVIEDHGSTNGTFVQGQRIHQLEIGPGASVNLGNATDGPLVGLTGAAAAVASPQAQPQQQPYAAQGANPGWAQQAPPQQAAPQAGWQQPQQAHQPAPIPQQQGPGGGAGAPPVYGDRSPTTFHQFALGRVMRIGRALENELVVSDLQVSRHHAEFHATPDGRFEIRDLGSHNGTYVNGQPIAKGGSQLLGPNDIVGVGHSTFRLVGDRLEEFVDTGDISFSARHLTVTVDGGKQILKDVSFGVPEKSLIAVIGPSGSGKSTLLKALTGYRPANQGDVLYDNRNLYKQFAELRQRIGLVPQDDILHKELTVKKALKYAAKLRFPADTTGAERDARIDEVLRELKLDIHKDKKVTSLSGGQRKRVSVALELLTKPSLIFLDEPTSGLDPGMDRDVMQLLRGLADDGRTVLVVTHSVAELAICDKLLVMAPGGSVAYFGPPEEALNFFGYDTWADVFSAFENYRDYDWAGRWKGSQHYQMYAADIDAVAPQSVQMPPMQAMRPPKPQGWMSQFTTLVRRYVSVIASDKGFLALTVILPLVLGSVSLLIDSGKDLLVNTEINPVTGKPVANGTALTVLLILAVGACFAGAANSVRELIKERVIYERERATGLSRSAYLMSKVFVLGVVTVLQGLMVGVIGFSSRTIPDQGLILGSQTLLELCIPIMALGFTAMMFGLIISALVKTAEKTMPLLVMFAIVQVVFTGCLFPLANSVGVNELSYLMPSRWAVAAAGATLDFNRISPPAKGDSNDPLWEHTVGAWGMDMAALIAIGVVCGFFVARFLRRHEPEVMRK

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Crispr_ID: CP022744_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022744_4

8598026-8598113

Orphan

Consensus_repeat	Method
GCCGTCCCGATCCCCCACCCACCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022744_4

>merge|CP022744|4|8598026-8598113|CRISPRCasFinder
GCCGTCCCGATCCCCCACCCACCCGTCCTTTTCAGCCCGTCCGGCGTCTGAGGCCGGGGCTCTCGCCATCCCGATCCCCCACCCACCC

>CP022744|4|4|8598026-8598113|CRISPRCasFinder
GCCGTCCCGATCCCCCACCCACCC	GTCCTTTTCAGCCCGTCCGGCGTCTGAGGCCGGGGCTCTC
GCCATCCCGATCCCCCACCCACCC

Protein	Signature genes	Signature genes Name	Protein_function
CP022744.1\|AXG58314.1\|8606082_8608053_+\|x-prolyl-dipeptidyl-aminopeptidase	unknown	unknown	gnl\|CDD\|235435
CP022744.1\|AXG58300.1\|8589522_8590233_+\|endonuclease	unknown	unknown	gnl\|CDD\|377374
CP022744.1\|AXG58303.1\|8591737_8592118_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377256
CP022744.1\|AXG58306.1\|8594529_8595744_+\|acetyl-CoA-acetyltransferase	unknown	unknown	gnl\|CDD\|236197
CP022744.1\|AXG58317.1\|8611096_8612050_-\|D-amino-acid-oxidase	unknown	unknown	gnl\|CDD\|334462
CP022744.1\|AXG58311.1\|8601681_8603148_+\|L-asparagine-permease	unknown	unknown	gnl\|CDD\|185009
CP022744.1\|AXG58313.1\|8604405_8605902_-\|metallopeptidase	unknown	unknown	gnl\|CDD\|341066
CP022744.1\|AXG58309.1\|8600032_8600740_+\|dehydrogenase	unknown	unknown	gnl\|CDD\|212491
CP022744.1\|AXG58299.1\|8589092_8589422_+\|hypothetical-protein	unknown	unknown	unknown
CP022744.1\|AXG58312.1\|8603396_8604299_+\|sugar-kinase	unknown	unknown	gnl\|CDD\|238573
CP022744.1\|AXG58301.1\|8590294_8590441_+\|hypothetical-protein	unknown	unknown	unknown
CP022744.1\|AXG58310.1\|8600716_8601442_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|197716
CP022744.1\|AXG58307.1\|8595785_8597960_+\|fatty-acid-oxidative-multifunctional-enzyme	unknown	unknown	gnl\|CDD\|236864
CP022744.1\|AXG58315.1\|8608049_8609294_+\|carboxypeptidase	unknown	unknown	gnl\|CDD\|349461
CP022744.1\|AXG58298.1\|8587935_8589039_+\|oxidoreductase	unknown	unknown	gnl\|CDD\|226855
CP022744.1\|AXG58302.1\|8590465_8591644_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225807
CP022744.1\|AXG58316.1\|8609382_8611083_+\|BCCT-family-transporter	unknown	unknown	gnl\|CDD\|376718
CP022744.1\|AXG58308.1\|8598309_8599938_+\|benzoylformate-decarboxylase	unknown	unknown	gnl\|CDD\|223107
CP022744.1\|AXG58304.1\|8592278_8593367_+\|racemase	unknown	unknown	gnl\|CDD\|224717
CP022744.1\|AXG58305.1\|8593363_8594506_+\|long-chain-acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173849

Protein	Function_ID	Function_description	E-value
CP022744.1\|AXG58314.1\|8606082_8608053_+\|x-prolyl-dipeptidyl-aminopeptidase	gnl\|CDD\|235435	PRK05371, PRK05371, x-prolyl-dipeptidyl aminopeptidase; Provisional.	0
CP022744.1\|AXG58300.1\|8589522_8590233_+\|endonuclease	gnl\|CDD\|377374	pfam04493, Endonuclease_5, Endonuclease V. Endonuclease V is specific for single-stranded DNA or for duplex DNA that contains uracil or that is damaged by a variety of agents.	8.5985e-102
CP022744.1\|AXG58303.1\|8591737_8592118_+\|hypothetical-protein	gnl\|CDD\|377256	pfam04237, YjbR, YjbR. YjbR has a CyaY-like fold.	4.44538e-15
CP022744.1\|AXG58306.1\|8594529_8595744_+\|acetyl-CoA-acetyltransferase	gnl\|CDD\|236197	PRK08242, PRK08242, acetyl-CoA C-acetyltransferase.	0
CP022744.1\|AXG58311.1\|8601681_8603148_+\|L-asparagine-permease	gnl\|CDD\|185009	PRK15049, PRK15049, L-asparagine permease.	0
CP022744.1\|AXG58313.1\|8604405_8605902_-\|metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	1.68844e-159
CP022744.1\|AXG58309.1\|8600032_8600740_+\|dehydrogenase	gnl\|CDD\|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	7.54583e-66
CP022744.1\|AXG58302.1\|8590465_8591644_-\|hypothetical-protein	gnl\|CDD\|225807	COG3268, COG3268, Uncharacterized conserved protein [Function unknown].	4.28865e-55
CP022744.1\|AXG58312.1\|8603396_8604299_+\|sugar-kinase	gnl\|CDD\|238573	cd01168, adenosine_kinase, Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine levels and the preservation of intracellular adenylate pools. Adenosine kinase is involved in the purine salvage pathway. .	1.9982e-56
CP022744.1\|AXG58317.1\|8611096_8612050_-\|D-amino-acid-oxidase	gnl\|CDD\|334462	pfam01266, DAO, FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.	4.98722e-27
CP022744.1\|AXG58310.1\|8600716_8601442_-\|transcriptional-regulator	gnl\|CDD\|197716	smart00422, HTH_MERR, helix_turn_helix, mercury resistance.	7.06393e-18
CP022744.1\|AXG58307.1\|8595785_8597960_+\|fatty-acid-oxidative-multifunctional-enzyme	gnl\|CDD\|236864	PRK11154, fadJ, fatty acid oxidation complex subunit alpha FadJ.	1.26184e-149
CP022744.1\|AXG58315.1\|8608049_8609294_+\|carboxypeptidase	gnl\|CDD\|349461	cd06242, M14-like, Peptidase M14-like domain; uncharacterized subgroup. Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. Two major subfamilies of the M14 family, defined based on sequence and structural homology, are the A/B and N/E subfamilies. Enzymes belonging to the A/B subfamily are normally synthesized as inactive precursors containing preceding signal peptide, followed by an N-terminal pro-region linked to the enzyme; these proenzymes are called procarboxypeptidases. The A/B enzymes can be further divided based on their substrate specificity; Carboxypeptidase A-like (CPA-like) enzymes favor hydrophobic residues while carboxypeptidase B-like (CPB-like) enzymes only cleave the basic residues lysine or arginine. The A forms have slightly different specificities, with Carboxypeptidase A1 (CPA1) preferring aliphatic and small aromatic residues, and CPA2 preferring the bulky aromatic side chains. Enzymes belonging to the N/E subfamily enzymes are not produced as inactive precursors and instead rely on their substrate specificity and subcellular compartmentalization to prevent inappropriate cleavages. They contain an extra C-terminal transthyretin-like domain, thought to be involved in folding or formation of oligomers. MCPs can also be classified based on their involvement in specific physiological processes; the pancreatic MCPs participate only in alimentary digestion and include carboxypeptidase A and B (A/B subfamily), while others, namely regulatory MCPs or the N/E subfamily, are involved in more selective reactions, mainly in non-digestive tissues and fluids, acting on blood coagulation/fibrinolysis, inflammation and local anaphylaxis, pro-hormone and neuropeptide processing, cellular response and others. Another MCP subfamily, is that of succinylglutamate desuccinylase /aspartoacylase, which hydrolyzes N-acetyl-L-aspartate (NAA), and deficiency in which is the established cause of Canavan disease. Another subfamily (referred to as subfamily C) includes an exceptional type of activity in the MCP family, that of dipeptidyl-peptidase activity of gamma-glutamyl-(L)-meso-diaminopimelate peptidase I which is involved in bacterial cell wall metabolism.	2.29352e-78
CP022744.1\|AXG58298.1\|8587935_8589039_+\|oxidoreductase	gnl\|CDD\|226855	COG4447, COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only].	5.66283e-19
CP022744.1\|AXG58316.1\|8609382_8611083_+\|BCCT-family-transporter	gnl\|CDD\|376718	pfam02028, BCCT, BCCT, betaine/carnitine/choline family transporter.	0
CP022744.1\|AXG58308.1\|8598309_8599938_+\|benzoylformate-decarboxylase	gnl\|CDD\|223107	COG0028, IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism].	1.01961e-128
CP022744.1\|AXG58304.1\|8592278_8593367_+\|racemase	gnl\|CDD\|224717	COG1804, CaiB, Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion].	6.83868e-108
CP022744.1\|AXG58305.1\|8593363_8594506_+\|long-chain-acyl-CoA-dehydrogenase	gnl\|CDD\|173849	cd01160, LCAD, Long chain acyl-CoA dehydrogenase. LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer.	0

>CP022744.1|AXG58307.1|8595785_8597960_+|fatty-acid-oxidative-multifunctional-enzyme
MTQSTTIRWEQDRSGVVTLVLDDPDQSANTMNQAFRDSLAVITDRLEAERDTIRGVIITSAKKTFFAGGDLRDLIRVTPDTAQDLFDGGLAIKRNLRRIETLGKPVVAALNGAALGGGYEIALACHHRIALDAPGSKIGCPEVTLGLLPGGGGVVRTVRLLGIADALLKVLLQGTQYSPQRALENGLVHDVAATQEELLAKARAFIEANPESQQPWDKPGYRIPGGTPAHPKFAANLPAFPATLRKQTNGAPYPAPRSILAAAVEGAQVDFETAQVIEARYFVELAAGQTSKNMIQAFFFDLQAVNSGANRPKGIEPRPVRRVAVLGAGMMGAGIAYSCARAGIDVVLKDVSLEAAVKGRGYSEKLCAKAVSRGRTTQEKADALLARITPTADPADLAGCDAVIEAVFEDTALKHKVFQEIQHVVAPDALLCSNTSTLPITALAEGVERQGDFVGLHFFSPVDKMPLVEIIKGERTGDEALARAFDLVRQIRKTPIVVNDSRGFFTSRVIGHFLNEGVAMVGEGVEPASVEQAAAQAGYPAKVLSLMDELTLTLPRKIRRETRRAVEEAGGTWTAHPAETVIDRMVDEFDRPGRSGGAGFYDYDESGRRTTLWPGLRDHFTRPGTEIPFRDMQERMLFAEALDTVKLLEEGVLTSVADANIGSIFGIGFPGWTGGVLQYINGYDGGLPGFVTRAHELATLYGDRFTPPALLVEKAEKGETFKDA
>CP022744.1|AXG58306.1|8594529_8595744_+|acetyl-CoA-acetyltransferase
MSTEAYVYDAIRTPRGRGKANGALHGTKPIDLVVGLIHEIRDRFPGLDPAAVDDIVLGVVGPVGDQGSDIARIAAVAAGLPDTVAGVQENRFCASGLEAVNMAAAKVRSGWEDLVLAGGVESMSRVPMASDGGAWFNDPMTNLNVNFVPQGIGADLIATIEGFSRRDVDEYAALSQERAATAWKEGRFERSVVPVKDRAGLVVLDHDEHMRPGTTADSLAKLKPSFADIGDLGGFDAVALQTYHWVEKIDHVHHAGNSSGIVDGASLVAIGSKEIGERYGLTPRARIVSAAVSGSEPTIMLTGPAPATRKALAKAGLTIDDIDLVEINEAFAAVVLRFVKDMGLSLDKVNVNGGAIALGHPLGATGAMILGSLVDELERQDKRYGLATLCVGGGMGIATIVERV
>CP022744.1|AXG58305.1|8593363_8594506_+|long-chain-acyl-CoA-dehydrogenase
MKRQIFAPEHDAFRETVRGFLAREVLPYYEQWEKDGIVSREAWRAAGKQGLLGLAVPEEYGGGGTRDFRFSAVLAEEFTRAGAPGLALGLHNDIIGPYLTGLATDEQKRRWLPGFCDGSLITAIAMTEPGAGSDLQGIRTHAEDRGDHWLLNGSKTFISNGILADLVIVVARTTPEGGAHGLSLFVVERGTEGFERGRNLDKIGQKAQDTAELFFHDVRVPRENLLGEFNGAFVHLMTNLAQERLSIAVSAIAAAEHLLEITTRYVKEREAFGRPLATKQHIRFEVAEMATECAITRTFLDRCIADHSDGTLDAVHASMAKWWATELQKRVADRCLQLHGGYGYMTEYPVARAFTDGRIQTIYGGTTEIMKEIIGRSLLG
>CP022744.1|AXG58304.1|8592278_8593367_+|racemase
MVELAGIGPGPFAAMLLADLGADVVRVDRPGGPGLAIDPRFDVTNRNKRSVLVDLKAPEGPARVLDLAARADILVEGYRPGVAERLGVGPEACHARNPGLVYGRMTGWGQQGLLAERAGHDIAYIALTGTLGMVGEPDRPPAAPANLLGDFAGGSLYLVVGVLAALHHARATGTGQVVDAAIVDGTAHLSAMLHGMMAAGGWQDRRAANLLDGGCPYYGTYETADGRYMAVGALEPRFYDEFVTLLGLTGFADARKDWTRWGELREAVAARFRSRTRQEWTAVFEGTDACVAPVLSLREAPHHPHLAARGTFTDHGGITQPAPAPRFSATPTTVSGGPALPGADTAEVAREWDVPDLTKGPE
>CP022744.1|AXG58303.1|8591737_8592118_+|hypothetical-protein
MAVPRNALRKWEKVREFALGMPGATEEFPWGETVAKVNRKVFVFLGVDDGSYPLGVTVKLKDEAAHAHALTCPGAEPAGYGLGKSGWVSIPLEQKGAPAAELLCDWVEESYRAIATKRFVAELDAR
>CP022744.1|AXG58302.1|8590465_8591644_-|hypothetical-protein
MNRPSRTDRPYDIVLFGATGFVGTLTAEYLAAHAPEGLRWAIAGRSEEKLERLRERLPGGAEIGVLRADVSDPASLRALAEHARVVATTVGPYVAYGDDLVAACADTGADYLDLTGEPEFVDLTYVRHDTRARETGARLVHACGFDSVPHDLGAYFTVRQLPEGVPLRIDGFVTADATFSGGTFASALGQFARGRQMLAAARDRGHHEPRLVGRRATAPTGAPRFAPEVGAWALPLPTIDAQIVRRSARALERYGPDFRYRHYAAVRHLPVAVGSVAAVGALVAAAQVPPARRWLSGRLRPGEGPGPEKRAKSWFRVRFVGEGGGRRVCTEVAGGDPGYDETAKMFAESALSLALDDLPPTAGQVTTAAAMGDALTERLRRAGITFRVASER
>CP022744.1|AXG58301.1|8590294_8590441_+|hypothetical-protein
MTSHRAPRPLADPNRPVERAVNAGLILATLAGLGWIVGMIYTLVQWPL
>CP022744.1|AXG58300.1|8589522_8590233_+|endonuclease
MTTVRIPAGWPATEERARAVQDELRGRVVLDEPGPPPGTGRVTGVDVAYDDERDLVAAAAVVLDAASLTVVAEATAVGRISFPYVPGLLAFREIPTVLAALEALPGPPGLVVCDGYGLAHPRRFGLASHLGVLTGLPTIGVAKNPFTFAHEDPDAPRGSTSPLLAGTEEVGRALRTRDGVKPVFVSVGHRVSLDNACAHTLALSPDYRLPETTRRADALCRRALREAAQVSRSPAD
>CP022744.1|AXG58299.1|8589092_8589422_+|hypothetical-protein
MPAGSSSKRERQYEHIKESAQDRGESTGRAKEIAARTVNKERARSGESKSASRTSTQDMSSGKRGGQRSGKGSQGPTYDQLYEEAKRRGVKGRSDMNKSQLQRALGGKS
>CP022744.1|AXG58298.1|8587935_8589039_+|oxidoreductase
MGNTRGTRRTRRTTRTVAAAAACAAALAALTAVPAQAQTPPDRSPHWELKDTASPDVRFRGLAAVDRRTAWVSGTGGTVLRTTDGGASWRNVSPPGAAELQFRDIEAFDARRAVVLAIGEGEASRVYRTDDGGQTWTESFRNTDAKAFYDCLTFFDRRHGLAMSDPVDGKFRILSTGDGGRTWKVLPNTGMPAALEGEAGFAASGQCLVSSGPRDVWLATGGAARARVLHSADRGLTWTASDTPVPAGDPARGVFALAFRDRAHGLAVGGDYRPDRPSPQAAARTGDGGAGWRSATRPVPAYRSGVAWLPHSRTTALAVGPTGTDLTTDAGRSWRTVDQGSYDTVDCTPDLGCWAAGEQGRVARLER
>CP022744.1|AXG58308.1|8598309_8599938_+|benzoylformate-decarboxylase
MGHRPAAAVLDILRDEGVDKVFGNPGTTELPFLAALADAHNTPEYILGIHEGSVVAMADGYARATHRPAFVSLHIAAGLANGLIGLLNARRSRTPLVVTAGQQDRRHLQQDPMLSGDLIGLATPAVKAAYDIQHARDLPLALRRAFALAVRPPAGPVFLSVPMDLLDEDTEVEVPARTPPPPQGPAAGIERAAVLLGAATRPAIVAGDGVGREDALGALVRTAEACGATVHHQPMSDCLNFPTTHPLYAGMLPPRHDAIREALTAYDTVLIVGAHAFTPHHYTPGPALPPGLTVVQLDSDPDEIGRNFPATAGLVGALAPSLHRLADLLGDQVPAHTARSRTLRTGQRHTAERDRAESAARAAYSPAPLAPWAAAHAVARGLPPDAVVVEEAITMGLLLRRLVRLDAPGSYTHTVGGGLGWGIGAAVGRALAEPGRPVVAVLGDGCTLFGLQGLWSAARQSAPVLFVVMNNGVYRTLQDTYAARGGEGVCPGTDLGPLDFTQAARFFGVDAVRAESADQLRELVAGAGELTGPLLIDVPIRS
>CP022744.1|AXG58309.1|8600032_8600740_+|dehydrogenase
METRTALVTGAAQGLGRQFAIALAARGYRVAGLDLVPQPETAARILDYVELVGDVGDETQIGEGLERVIDRFGTLHVVVNNAGVHPAKPFEETTVEDWRRVMRVNLDAPFLVTRAALPYLKAAGWGRVVNIVSTAVFTAPPTMVPYVASKTGLIGFTRALATALGPYGITVNAIAPGPVRTATAEHLRARQAVARTLEPTLEPSDLVSTLLYVVDEGSGFLTGQTLTVSGGSACL
>CP022744.1|AXG58310.1|8600716_8601442_-|transcriptional-regulator
MTTEATDASEAGGPTLTIDELAARAGVTVRTVRFYGTKGLLPPPVIGPRRVGHYGGEHLARLALIEELQQQGMTLAAIERYLQQLPADLSPHDLAIHRAVVASWAPDVMETVTREELQRRAGRALSDDDVERLAAMDVVRREEAVFRVDLGLLRLGVRLLDVPLSQEAILASRKVLIEHSRAAAHELARLFRGEVSERDARDVKSLSADMEPLVVQALLTTFQRSLKEELREWSSQAGGSA
>CP022744.1|AXG58311.1|8601681_8603148_+|L-asparagine-permease
MSKDAVGSAQTAARTATAQVPADAGDAGYSKDLKARHVNMIAIGGAIGTGLFLGAGGRLDTAGPALALAYLVCGVFAFFVVRALGELVLYRPSSGSFVSYAREFLGEKGAYVAGWMYFLNWSTTGIADITAIALYTHYWSLFTDIPQWTLALIALAVVLAVNLISVKIFGEMEFWFAIIKVATLVGFMLIGIFLLATRHEVDGRTPGLSVITDNGGTFPHGLMPVVIVMQGVIFAYAALELVGVAAGETAEPEKVVPRAVNSIMWRVGLFYVGSVVLLALLLPGSVYSAGESPFVTVLSRIGVPAAGDVMNLVVLTAAMSSLNSGLYSTGRILRSMAMAGSAPRFTARMNRSQVPYGGILLTCAVCVLGVGLNYLMPSQAFEIVLNVASLGVISTWVIIMICHLVFVRRAKAGLLTRPSFRLPGSPVTEITTITFLLAVLALMANDPDVGRKTLLLIPLIALMLITGWFAVRHRVTRTTDQELTGFTD
>CP022744.1|AXG58312.1|8603396_8604299_+|sugar-kinase
MSRDTDVLVLGGAGVDTIVYVPELPLPYADSYLIDSGIRTRAGQTGDFVAVGLSALGLRTHHLDLLGDDPEGDLVRALHRDRGIELTAVSQPAGTKRAVNLVGPDGRRLSLYDTSRAHPDDRLPEATVRALAATSRHAHVSITQPCAHTLPVLRETGVTISTDLHNWDGENDYHEPFAHTADLVFLSATALPDPERTMRRIVEHGRAQTVVATAGAEGAYLLTDDTLTHIPPATPPAPVIDTNGAGDAFAAAYLYGHLNGEPPYRCAAYGTLAGAHACTIPSTETAAMTRTELLARTEAP
>CP022744.1|AXG58313.1|8604405_8605902_-|metallopeptidase
MHRRILAPGALAAASLLLAIPASAASSAPGAPGIGDPYYPAYGNGGYDVSHYDLRLRYQPATDRLEGTTTLLARTTEDLSRFNLDFLLDVSEVRVNGAKASFTTSGEHELEITPKTPLAKGTAVTVVVRYSGVPSTKEAYGFNAWLRTPDGGVAAGEPEGAWWWFPSNDHPLDKATFDVSVQVPDGHQAISNGTLQSTSSRAGWTRYNWRSNKPQTTYLATLAVGRFDVTTGTSESGIPVINAYSKDLGDSDGAARASVERTGEVADWLTEYFGPYPYNALGGYVPNTPQVGYALETQTRPFYSPRQFANGSNVSVVVHELAHQWYGDEVSVEHWKDIWINEGFARYAQWLWSEHEGEGTTQEIADYVYASRPADDPFWTVKPGDPGPENQFHISVYDRGALAVQALRNEVGDAAFFAILKGWPTEYAHGNASVGDFQRYAEEVSGQPLAGLFDTWLFQPVKPAAPAARSASIAAVPGVPEQPKSWKKIAATNDVHEH
>CP022744.1|AXG58314.1|8606082_8608053_+|x-prolyl-dipeptidyl-aminopeptidase
MYRPRMPTRMRFTTWRQLAVVAVAALTAALLTPAAAHGTPRESRPVYSYDNAVREAVWVDTGLDGDGDGRTDRVAADIVRPREPAQQGRKIPVIMDASPYYSCCGRGNESQLKTYDADGDVVQMPLFYDNYFVPRGYAFVGVDLAGTNRSDGCVDVGGRSDIQSAKAVVDWLNGRAKGYTTRTGGKQTKATWTNGRTGMIGKSWDGTIANGVAATGVKGLKTIVPISAISTWYDYYFSEGAPLYDSGPDWLSDYVDSPDARAKCGAVQQRIVDGAPRTGDLTPFWSERDYVKAASKVRASVFLIHGMQDLNVRMQHVGPWWDALAKNGVERKIWLSQTGHVDPFDFRRTAWVDTLHRWFDHELLGYDNGIDREPMADVERHPDQWTTSKMWPPAGTAATTLRPAEGTREGVGRLGLRPGTGTETFTDDPKLSETDWAARIDTATPDKAGFTTGPLTKDLRLSGSSKVTVTATPTTSTAHLSAVLVDLGPDTIRDYGASGEGITTLTDRTCWGASTTGDSACFKETAAKTTDVDFTVVSRGWADLGNHADPGKGAPLTPGKAYTITLDLGATDHVVPAGHRLALIVAGTDKDLIDPPSTTPTLTVDLTRTSARVPFVGGIAAFARATAGSPAVAPEATRLDGVTTPRTTQRIPGEAR
>CP022744.1|AXG58315.1|8608049_8609294_+|carboxypeptidase
MIRALTLTTAALAASLVAVPAAATEAPPRTGFEQTNGARWTTQPEEQDFLAAVDRASTRVSVGSLGTTKQGRPLQLVRVGARHAPNTVLLVCGQHGDEPSGREACLTTIRDLAYAKDRPTRRLLERTTVLVVPTANPDGRAADTRGNSDGVDINRDHLALQTLEGRALAAVIRDRRPDLIYDLHEYGSTPPYYDKDLFDLWPRNLNTAPAVHDEAETLSQAYVRPAARGAGYTTGTYGIWTDPVTGEPIRQVAGDGQERILRNMSGIKHAIGLLIESRVEPLTGTDEPANNRRRVDSQLAALKGLFAYTDERRTQVERATDAARRAGWTDTGPVYVGGADNDPPEPAEVIQDPPCGYRLTAGQYAEIKDELALHGVRTHGTHVPLRQPLRALVPLLLDERAPYHLTAAEPDTAC
>CP022744.1|AXG58316.1|8609382_8611083_+|BCCT-family-transporter
MTEDLKKRGGREGASSPPGRSTDRVVFGVTAAITVAFVIWGAAGTDSLESVSTKMLNGLIHNGGWAFMLAASCFVVFALWIAASRYGRIHLGAEGEEPEFKTVSWVAMMFSAGMGIGLMFYGVSEPLSHYTTPPPGTTPANSGERMETAMATTLFHWTLHPWAIYAVVGLAIAYSTYRKRRRQTISAVFTPLIGEKHANGAGGRVIDILAIIATVFGSAASLGLGALQIGSGFQELDWMDDVSTGLLVAIIAVLTLAFVASAVSGIERGIQWLSNTNMVLALVLALFVFVAGPTIIVLDLLPTSVFAYLGDLPQLAGRTEASGGAGVADWLGSWTVFYWAWWISWTPFVGMFIARISRGRTIRQFVGGVILVPSTVSLVWFAVFGGSAMRLREGGALRGESTPEGQLFGLLQEFPIATVTSLLVMILVGIFFVSGADAASIVMGTLSQKGALEPGRFVVVFWGVVTGAVAAIMLLVGSGQGDALTGLQNLTILAAAPFVLVMIGMCVALMRDLRQDPVIVRGEMGSEAVELAVIEGHKRYDGDFEIRVGPGAGTETEGDPLGHDHT
>CP022744.1|AXG58317.1|8611096_8612050_-|D-amino-acid-oxidase
MNSGLGDEIVVVGGGVVGLTTAVVLAERGRRVRVWSRDPVEGTTSAVAGALWWPYHIEPVALARAWALRSLDVYEELAARPEETGVRMVEGVLGEADPDAADAWVTDRLPGLRATTAEEYAGTGTWVRLPLIDMPAHLPWLRDRFVAAGGTIEARTVADLAEVDAPVVVNCTGLAARELVPDPSVRPVRGQLVVVENPGIHTFVVSTDADGEMAYFFPQPGRLLLGGTAVEDEWSTEPDPVTAAAIVRRCAALRPEIAGARVLEHRVGLRPARDAVRLEREPLSGGRVLVHNYGHGGAGVTVAWGCAEEAAGLAASP

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Crispr_ID: CP022744_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022744_5

9178676-9178780

Orphan

Consensus_repeat	Method
GGAGGACACCTGGAAGCCGTCCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022744_5

>merge|CP022744|5|9178676-9178780|CRISPRCasFinder
GGAGGACACCTGGAAGCCGTCCGGAGCCGTCTGGGCGCAGCCGCCGGGGCACTGCGGGGTGGCTGTGCCGGGGTCCCTCAGGGAGGAGACCTGGAAGCCGTCCGG

>CP022744|5|5|9178676-9178780|CRISPRCasFinder
GGAGGACACCTGGAAGCCGTCCGG	AGCCGTCTGGGCGCAGCCGCCGGGGCACTGCGGGGTGGCTGTGCCGGGGTCCCTCAG
GGAGGAGACCTGGAAGCCGTCCGG

Protein	Signature genes	Signature genes Name	Protein_function
CP022744.1\|AXG58800.1\|9166225_9166834_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366102
CP022744.1\|AXG58807.1\|9172966_9175891_-\|putative-regulatory-protein-WdlA	unknown	unknown	gnl\|CDD\|238121
CP022744.1\|AXG58813.1\|9185667_9186957_+\|putative-ROK-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224851
CP022744.1\|AXG58801.1\|9166983_9167712_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378456
CP022744.1\|AXG58810.1\|9179654_9180623_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372019
CP022744.1\|AXG58809.1\|9179061_9179568_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379860
CP022744.1\|AXG58802.1\|9167679_9168972_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378416
CP022744.1\|AXG58818.1\|9189919_9190882_-\|oxidoreductase	unknown	unknown	gnl\|CDD\|235736
CP022744.1\|AXG58814.1\|9187035_9187350_+\|hypothetical-protein	unknown	unknown	unknown
CP022744.1\|AXG58804.1\|9170121_9171369_-\|integral-membrane-protein	unknown	unknown	gnl\|CDD\|226614
CP022744.1\|AXG58812.1\|9184587_9185586_+\|putative-phosphotransferase	unknown	unknown	gnl\|CDD\|366736
CP022744.1\|AXG58816.1\|9188470_9189139_+\|dipeptidase	unknown	unknown	gnl\|CDD\|350618
CP022744.1\|AXG58811.1\|9181345_9184513_+\|bifunctional-P-450:NADPH-P450-reductase-1	unknown	unknown	gnl\|CDD\|99802
CP022744.1\|AXG58806.1\|9176047_9177064_+\|transcriptional-regulator,-LysR-family	unknown	unknown	gnl\|CDD\|223656
CP022744.1\|AXG58808.1\|9177064_9178549_-\|metallopeptidase	unknown	unknown	gnl\|CDD\|341066
CP022744.1\|AXG58817.1\|9189142_9189832_-\|hypothetical-protein	unknown	unknown	unknown
CP022744.1\|AXG58799.1\|9164600_9166118_-\|cytochrome-P450	unknown	unknown	gnl\|CDD\|365848
CP022744.1\|AXG58805.1\|9171577_9172924_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350610
CP022744.1\|AXG58803.1\|9169029_9170061_-\|integral-membrane-protein	unknown	unknown	unknown
CP022744.1\|AXG58815.1\|9187374_9188403_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|187551

Protein	Function_ID	Function_description	E-value
CP022744.1\|AXG58800.1\|9166225_9166834_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	8.80669e-11
CP022744.1\|AXG58807.1\|9172966_9175891_-\|putative-regulatory-protein-WdlA	gnl\|CDD\|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	1.7016e-87
CP022744.1\|AXG58813.1\|9185667_9186957_+\|putative-ROK-family-transcriptional-regulator	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	5.18548e-52
CP022744.1\|AXG58801.1\|9166983_9167712_+\|hypothetical-protein	gnl\|CDD\|378456	pfam10615, DUF2470, Protein of unknown function (DUF2470). This family is a putative haem-iron utilisation family, as many members are annotated as being pyridoxamine 5'-phosphate oxidase-related, FMN-binding; however this could not be confirmed.	1.11125e-08
CP022744.1\|AXG58810.1\|9179654_9180623_+\|hypothetical-protein	gnl\|CDD\|372019	pfam12294, DUF3626, Protein of unknown function (DUF3626). This family of proteins is found in bacteria. Proteins in this family are typically between 294 and 374 amino acids in length.	8.51589e-76
CP022744.1\|AXG58799.1\|9164600_9166118_-\|cytochrome-P450	gnl\|CDD\|365848	pfam00067, p450, Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.	8.17382e-72
CP022744.1\|AXG58802.1\|9167679_9168972_-\|hypothetical-protein	gnl\|CDD\|378416	pfam10282, Lactonase, Lactonase, 7-bladed beta-propeller. This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyze 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway. Structures of proteins in this family have revealed a 7-bladed beta-propeller fold.	2.55815e-136
CP022744.1\|AXG58818.1\|9189919_9190882_-\|oxidoreductase	gnl\|CDD\|235736	PRK06196, PRK06196, oxidoreductase; Provisional.	0
CP022744.1\|AXG58804.1\|9170121_9171369_-\|integral-membrane-protein	gnl\|CDD\|226614	COG4129, COG4129, Predicted membrane protein [Function unknown].	3.65027e-11
CP022744.1\|AXG58812.1\|9184587_9185586_+\|putative-phosphotransferase	gnl\|CDD\|366736	pfam01636, APH, Phosphotransferase enzyme family. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase. This family is related to fructosamine kinase pfam03881.	1.25116e-20
CP022744.1\|AXG58816.1\|9188470_9189139_+\|dipeptidase	gnl\|CDD\|350618	cd14843, D-Ala-D-Ala_dipeptidase_like, D-Ala-D-Ala dipeptidase, includes uncharacterized enzymes. This subfamily of D-Ala-D-Ala dipeptidase (also known as D-alanyl-D-alanine dipeptidase vanX; VanX; EC 3.4.13.22) also includes several uncharacterized proteins. This is a Zn2+-dependent enzyme that mediates resistance to the antibiotic vancomycin in Enterococci and other bacteria (both Gram-positive and Gram-negative). It is part of a gene cluster that affects cell-wall biosynthesis. The operon triggers the termination of peptidoglycan precursors by D-Ala-(R)-lactate instead of D-Ala-D-Ala dipeptides. The enzyme is stereospecific, as L-Ala-L-Ala, D-Ala-L-Ala and L-Ala-D-Ala are not substrates. It belongs in the MEROPS peptidase family M15, subfamily D.	2.35051e-64
CP022744.1\|AXG58811.1\|9181345_9184513_+\|bifunctional-P-450:NADPH-P450-reductase-1	gnl\|CDD\|99802	cd06206, bifunctional_CYPOR, These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via FAD and FMN. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently bound FAD as a prosthetic group) are present in chloroplasts, mitochondria, and bacteria in which they participate in a wide variety of redox metabolic pathways. The C-terminal domain contains most of the NADP(H) binding residues and the N-terminal domain interacts non-covalently with the isoalloxazine rings of the flavin molecule which lies largely in a large gap betweed the two domains. Ferredoxin-NADP+ reductase first accepts one electron from reduced ferredoxin to form a flavin semiquinone intermediate. The enzyme then accepts a second electron to form FADH2 which then transfers two electrons and a proton to NADP+ to form NADPH.	3.27102e-138
CP022744.1\|AXG58806.1\|9176047_9177064_+\|transcriptional-regulator,-LysR-family	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.40609e-20
CP022744.1\|AXG58808.1\|9177064_9178549_-\|metallopeptidase	gnl\|CDD\|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	3.76979e-138
CP022744.1\|AXG58805.1\|9171577_9172924_+\|hypothetical-protein	gnl\|CDD\|350610	cd14728, Ere-like, Erythromycin esterase and succinoglycan biosynthesis related proteins. This group contains erythromycin esterase, which shares conserved active site residues of the Tiki/TraB family. Erythromycin esterases (EreA and EreB) disrupt erythromycin via the hydrolysis of the macrolactone ring. A critical catalytic histidine acts as a general base in the activation of a water molecule. Macrolides act by inhibiting bacterial protein synthesis by binding at the exit tunnel of ribosomal subunit 50s, blocking the translation of the polypeptide. Erythromycin esterase, typically found in integrons and transposons, confers antibiotic resistance through the disruption of the drug ring structure. EreB substrate profile is substantially broader than that for EreA, being able to also metabolize semisynthetic derivatives such as azalide azithromycin.	1.92012e-102
CP022744.1\|AXG58809.1\|9179061_9179568_-\|hypothetical-protein	gnl\|CDD\|379860	pfam16571, FBP_C, FBP C-terminal treble-clef zinc-finger. FBP_C is a family from the C terminal end of fibronectin-binding proteins. It forms an extended four-cysteine zinc-finger with a unique structural fold. Fibronectin-binding proteins bind to elongation factor G - EF-G, which is mediated by the zinc-finger binding to the C-terminus of EF-G. FBPs release ribosomes by competing with them for EF-G.	3.43629e-87
CP022744.1\|AXG58815.1\|9187374_9188403_-\|hypothetical-protein	gnl\|CDD\|187551	cd05240, UDP_G4E_3_SDR_e, UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs. Members of this bacterial subgroup are identified as possible sugar epimerases, such as UDP-glucose 4 epimerase. However, while the NAD(P)-binding motif is fairly well conserved, not all members retain the canonical active site tetrad of the extended SDRs. UDP-glucose 4 epimerase (aka UDP-galactose-4-epimerase), is a homodimeric extended SDR. It catalyzes the NAD-dependent conversion of UDP-galactose to UDP-glucose, the final step in Leloir galactose synthesis. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.82105e-98

>CP022744.1|AXG58808.1|9177064_9178549_-|metallopeptidase
MSPDTRPRRGLRLTLAAAIAMTAALTAPAAGAAPATSRDSVPVPGAPGLGDPLFPLDGNGGYTVDRYLLDFDWQAPKTPFRAKATIRATATTELSRFNLDFAGNTLHEVTIDGTPAEAVREGDELIVTPWLPLPRKSTFTVTVTYTADPTQIRHRDDAIEDYGWIPTPSGTVLYPQPNGAKMVFPANDHPSQRAPVTFRVTAPTGLTAVANGRLVSREPLTGGRERWTYDSEQPVSTQLVQMAVGRLTAVDRPTTNGVPLRDFVPDELVDRTDEYLDLTPQHLRWLEQRLGAYPFKRYGVLVGDTDLGVALETQTLSLVPKADLLGTRVDAERTLVHELVHQWFGDSVALRTWSDLWLSEGHARFYERLYSEEHGGDSFEAAMKTAYTNHNLWRRDFGAPAEPTEPNLFKRMRYDGSALVLYALREKVGDETFRKIDRAWVTKYRGRTASTQDFMDLASAVSGQDLASFLRPWLYGPTTPPMPNHPDWVATPVP
>CP022744.1|AXG58806.1|9176047_9177064_+|transcriptional-regulator,-LysR-family
MELRDVETFLEVARVLHFGRAAERLHVSQGRVSQIIKGLEREVGGALFERSSRRVRLTPLGERFRTGAAEGHDRLTATLRECRAVARQVGDRLRIGYQWTMGGELTDRLVSGFTRAHPHCEVVVSSLVFRAGGNLVPLAGGTDVDLVLRWSPGGDGSAVEAPGLVVGPLLAAVPRGVLVPAAHPLAGRRAIVLDDLLPYELLRLPDALGAPLRERWVPTHTSSGRALRHTDEDMSRLMGTEHLPVEDVLALVAQGRALHLTIAGLLDRVPFPGLAVVPVLDMPPMVVVPVWRAARENATIRAFVESAARTTEAERAVVTREAASVRTSVVRSVREAAR
>CP022744.1|AXG58807.1|9172966_9175891_-|putative-regulatory-protein-WdlA
MPRGERPLKAGDARIVAFAAELRRLRNKAGSPTYRQLAERAHYSVSTLSGAASGKVLPTLAVTLAYVRACDGDVAHWERAWHALAAELGAAAEASDADSSDGPAPYVGLAAYQTSDAAWFFGREGLVEELVRRLRQQRLLLVVGASGSGKSSLLRAGLVPRLAPGATPVVFTPGTRPMEECAVRLSAAANLTPGRVYRELLDDPANLGRLARQIGARSDAADSEVVLVVDQFEELFTHCAPAERDHFITALLTAATADGNRCRVVIGVRADFYTHCTHHPGLVAAMRDAQIPVGPMDLEDLRRAVVQPAVRAGLTVEGALLTTLATQALGQAGVLPLLSHALRETWRRRRGNALTLDAYRATGGLEGALARTAEEFYAELGAERQKLARQVFVRLTALGEGTEDTRRRVPLGELARLGTPAGAVEDTGRGPAMGEDVGAVLEGAARARLVTLDQDRVELTHEALIRCWPRLHGWLTEGREQLRVLRQLTEAARTWESLGRDPDALFRGARLALAREVEDQVLSSEERTFLDASAAAERAESARGRRRARQMRRLTALLAVLLAVAVTAAVLALRARDELTRERNKVLAREVAVDAVALRQDRPALAAQLGVAADRLSPSATTRDALLGVTAASLLGHEQAVSALAFRPDGRMLATAGYDYTVRLWDVTDPFRPVAVGEFAGGPDIMTAVAFSPDGRRLATGGRDRTVRLWDVTRPRRPAPVRVLTGHGDIVFSVAFSPDGRTLASGSYDHTVRLWDVSSAASGPVVLRGHRLNVKPIAFSPDGRTLASGSDDRTVRLWDVTSPRRPRPLAVLTGHRDFVDALAFSPDGRTLASGSDDRTVRLWSVADPRRPRTGTVLTGHTDVVSSVAFSPDGRLLASGSTDRTARLWDLPATGAPGLRSELTGHLGAVNVVAFRPGEGDAPLATGSSDHTAQIWQTDAAHAGRRACARARPVITRAEWNRWLPGIPYSPPCGD
>CP022744.1|AXG58805.1|9171577_9172924_+|hypothetical-protein
MLITLGVALPAGIPAAAATTAPTATTLPAAATASTQDVVAALDRAAHPLRTVEPGGDTGDLRPLDRMIGDARVVGLGEATHSSHEFFALKDRVFRHLVEEKGLRTFALEAPWSTGLRLDAYVLHGKGDPRRIMREEFQRDYLWWNNTDYLRLVEWMRAYNVRHPEDPVRFMGDDIAWSGPELYDAVSDHVAATHPGASARLAELYRGLRPTVATGTYIEEYLARPYAERKEMADRTGRALDLVRHLGPGTDRESYGRALQNATVIDQTARQYAWDLEDPAQIAEAMRYRDRAMAANVVWWQRHTGTKVLLSAHNNHVGYVPDDPVHYPKVQGAFLRDSLGAGYVSVGLTFHHGSFNATGQDDETVRRWTLGPPGPDSNERTLDRVRHRDHVLDLRTAGPPARDWLRQARPTRSIGTAYPELPDDIALARSHDVLIHLHSIGAARLRDR
>CP022744.1|AXG58804.1|9170121_9171369_-|integral-membrane-protein
MRQVREGTASLRGFVKRHRDPVVVQALRSTAAATVAYVIALRFSPEAAPLTAPLTALLVVQVTLYSTLTTGIRRVNSVVAGVLVAIAFSLLVGLTWWSLALLIVASLAVGHLVRVDEFVPEVAISAMLVLGVTTVGDTAWARVLETLIGAVVGLGCNLLLAPPVWVGEAGESIEGLARRVRQLMLSMGEEAAGRTPVEHATERLHEARRLDHAIVEVDAALRQAEDSLRLNPRVREGLLHRVVLRTGLDTLEICTVVLRVLARTFTDLAKHRETESLFAPGTGAVVEQLLSEIADAIVSFAVLVTTHVSENADAAEARLTTELRQAAATRDKLAQLLLEEVQRDAGQWQLQGAVLTEVNRILDELDTEHRSHRLLEELDRTAREQRERMPRLTRLRENLKVPEPLRRNRADAGRR
>CP022744.1|AXG58803.1|9169029_9170061_-|integral-membrane-protein
MTDTGVRIDGNTLRLPGGVAVRFVRTLRLPETGTHPLPPGLGEFPVRRISDHADRVPERWRARGGVMLPVYLREAMWLSFAGTTEPAALQVGVGKVCAVSGRPWSDRLSRDPQNYLVLPRQPWLDGINSGKGTVRQFVAVPLGLGATVEGQVTGEETWGGVQLQTFPLNARELARWQEEERRRAERTRAFPQAAGYGAAMPMAASAPAAPAAAPRRAAAMGLGVGGSMRQEVYRDDRPVGDWSAEPAGRVFVHLVTPPEWRRITGEAPPPSPVDRAAYTRAGLPWFDYYDQDAEDLASTDTLEGVKPVGDWIGDDHEPWQEPSPQQVRPLKDAPGKPVEDGDW
>CP022744.1|AXG58802.1|9167679_9168972_-|hypothetical-protein
MPRVIHAKVAFANATSDDVRGDMGTGGWSRRRFVGALTGTAAAATLPACGDESTPSGASTPSAGSASATAPDTNERPQTEGRESSGSHPLYLGTYTSAEGGGKGIGLATYDSATGRVTDGGLLAETANPSFLAVHPNGRTLYAVNERDDGGVTAVRLADRRVLGTRSSAGAGPCHLSVHPSGRWLLSANYTSGSVTVHPIAASGALGEHTDVVTHSSPPPGPNSERQDGPHAHQIVTSPDGGHVLAVDLGTDTVYTYRLDQARGTLTEVSRASAKPGAGPRHLTFHPGGRYAYLANELDNTITVCAYDPATGRLTIGDPQPTGTGDVTSYPSQILVTADGSYAYLANRGHNSLTRYAVEAKGARVRLLDTVPVHGDWPRHTAFSPDGRLLFVANQNSGSVTVFHVDRASGELRLAGEPFASPVAVCALPL
>CP022744.1|AXG58801.1|9166983_9167712_+|hypothetical-protein
MGDSQSWAAVPSAAERARSVLAAAWSCAVTAEGGREEFVGAHSVSDDGRVLLHVPEESTLLATAVCAPRGEPSAVLEFADVAPVPVRSRIRTRLWMAGWFTADEEGHLAFRPTRVVLREPSGAVVVGLDDFAAATPDPLATAEARLLTHLADCHADAVERLTRLVDSDSLHGAVRVQPLAVDRHGLTLRIERARAHGDVRLAFHRPADDVGQLTERMHVLLTRAGAASCPRTLQRQRTDGDG
>CP022744.1|AXG58800.1|9166225_9166834_+|TetR-family-transcriptional-regulator
MAANQGGRTRRRLSTEERREQLLTVGARLFSESPYDEVWIERVAEIAGVSRGLLYHYFPTKRDFFAAVVERESERMLRMTAAVPGIPVREQLGAGLDTFLEYVQAHAHGYRAFHRADAAGDQTVRRVYQRALAAQERQILAAVAADPEWSALSETRPDLRLAVRGWLAFTTAVCLEWLRGSDLTREQVRDLCARALLGVITP
>CP022744.1|AXG58799.1|9164600_9166118_-|cytochrome-P450
MAERTPGTGRPRGFRSAELGWPELERLPHPPRRVPLLGDVLGVDRHSPLQDTVRHARRLGPIFRRKAFGREFVFTWGADLVADLADEARFAKHVGLGVANLRPVAGDGLFTAYNHEPNWQLAHDVLAPGFNREAMQGYHAMMLAVAGRLTDHWDRAQAAGLEVDVPGDMTKLTLETIARTGFGHDFGSFERARPHPFVAAMVGTLTYAQRLNSVPFPQLLRAAARRNEADIAHLNRTVDELVRDRRTSGADGGGDLLDRMLETSHPQTGERLSAENVRRQVITFLVAGHETTSGALSFALHYLARHPEIAARARAEVDQVWGDTAEPGYDQVAKLRHVRRVLDETLRLWPTAPAFAREAREDTVLAGVHPMRRGAWTLILLPMVHRDPAVWGADAERFDPDRFEAKAVRSRPAHTYKPFGTGARACIGRQFALHEATLVLGLLLRRYELRPDPAYRLRVTERLTLMPERLRLRLERRSAPVTVPSPAAAEAPASEPRCPVHGAGD
>CP022744.1|AXG58809.1|9179061_9179568_-|hypothetical-protein
MRSLTEQDIRTSFINCSKGEAKRLAVPRDLAERPWDDLDFLGWRDPGAPDRSYLVAERDGKLLGVTMRFPSSQRGFLHRSMCSLCLTTHRGGGVSLMTARKAGTAGREGNSVGLYMCTDLACSLYLRGRKIPDSGSRFEESLTLEEQISRTTDNLNAFLGKLRDPVRN
>CP022744.1|AXG58810.1|9179654_9180623_+|hypothetical-protein
MDFRDVGSVRARLALRHVAGVSSGPALAGDLRITLNFHPDRLVRGLSVLDALAQDGAYHSQFVTGTSNGGLTAHPGGDRWRWESRIFGGAYDDADPHERPVYGALNFRGQVVGAAPRFGSSHFRLTGAASARATFCYPDSAAEPVDFGVAAGMSLIALAEGDEQDALNDYIEAQVHAGVVLARDVEALVLDACYRGTSVEAAARRLPCPVEWHPGYRLTVAELYRHADYRGPEYADLGARIAEDGRIDPRIIGDAARTGRHELQDLKMVWHTLARFGAPEGAGTALRQSAVYSSVVEAGVTEAGVAEAGVGGHTPEVSTPSA
>CP022744.1|AXG58811.1|9181345_9184513_+|bifunctional-P-450:NADPH-P450-reductase-1
MPPTAQTTPDLPDVPVVDISDTGPGCTPLQQVMGLMREHGPLLVRRLHGRDVTFVADLDLVTELADETRFAKAVGPALENVREFAADGLFTAYSEEPNWARAHDILMPAFALGSMRTYHPVMLEVARRLIGSWDRAAFAGRPVNVPDDMTRMTLDTIGLAGFGYDFGSFDRDEPHPFVESMVRCLEWAMTRLARTPGSDHTAADEAFRTDAAHLAQVVDDVINARLASGESGGDDLLGLMLTATHPADGTTLDTTNIRNQVITFLIAGHETTSGAMSFAMYYLAKHPAVLQLVRREVDELWGDTADPEPTFDEVGRLTYTRQVLNEALRLWPTAAAFSRQAREDTLLGGRIPLRAGQALTVVAPMLHRQPVWGDNPELFDPSRFTPEAEAARSPHAFKPFGTGERACIGRQFALHEATMLLALLVHRYRLHDHADYRLTVKEALTLKPDGFTLTLTPRTGADRAHPPLPGAAPLTEAAAVSDAALPARVRRGTRALFLHGSNYGTCRDFAARLADEAAAVGCETEVAPLDAYAGGLPTDRTVVITAASYNGQPTDDARQFATWLDEATDAGGVHYAVLGVGDRNWAATYQHVPTRIDERLAELGATRLLDRAAGDASGDLTGTVRAFTADLRTALLTAHGDPDAVAPAPEPETAYEVRTLTSGPLDALAERHDLVPMTVTEAYGLTAPGHPRLKRFVRLALPAGTTYRTADHVTVLPVNDKALVERAAAALGVDLDSVLDIRATRPRSDGLAVDRPLTVRQLLAHHVELLRRPSAGQRSALATANPCPPERAQLAALGDDDPRTLVELFEAYPALRGALDWPALLDLLTPLRPRHYSVSSSPATDPGHVDLMVSLLEAPARSGNGTYRGVGSGHLAGVQPGDTVLARVQPCRDAFRVDHSRPVVMIAAGTGLAPFRGAVADRVAALARGEQLPPALCYFGCDAPEADFLHAEELRAAQTAGAVRLRPAFSAVPEGEVRFVQHRVAAEADEVAELLDAGARVYVCGDGSRMAPGVREAFRTLYRERTPGADEAAAERWLDGLVRDGRYVEDVYAAG
>CP022744.1|AXG58812.1|9184587_9185586_+|putative-phosphotransferase
MDSWERARLVLDGAHLSADRLAHLRPLTGGTYNTVEELLLTDGSRYVLKVAPDPSVPGMRHEKRLLVAEAEFYRAAAEAGVPAPRTLALGEEPAVAHLLMTACPGEPWDGSVTDAERAPLRTELGRQTARLHRITGPGFGYPSGALGPLAPDWRTAFGIMVEAVLDDVRDYRARLPRPVETVARTLRAGFPALDEVITPRLVHFDLWDGNILLDRPAGEEPRIGGLIDGERMFWGDPLADFVSLALLADIEQDTAFLAGYRDAGGRTDFDASARLRLALYRAYLYLIMLTEGVPRAFEADRWRWLEEAVAPELVAALDEIEDLAPRLGPVGP
>CP022744.1|AXG58813.1|9185667_9186957_+|putative-ROK-family-transcriptional-regulator
MAGRNGRTVRDLRRANRTAVLQRLYFDGPLSRFELGPVTGLSSGSISNVVADLVADGLLEEAGSVESDGGRPRTLLRVAPGSGHMIGVDVGETRVRIELFDLTLTELARTERPLTDREYEVEVIVGHIRDGIAEVLAEVGLAPERLLGVGIGVPGIVEYTPERGAVVHGQTIGWDAVPLEELLRAGSPLPDDVRYFIDNGAQTLGQAEMWFGGGRGARNAVVVLFGSGVGACLVTPEVDHGRAVEWGHLTVRVRGRRCRCGALGCLEAYAGAESLLRRWHEEGGRPPQGVDEETALTAMMAAAYPGESGTADPVALAVLEETAEYLGAGLSDLINLFQPERILIGGWAGLQLGARFLPAVRRHAMSYALRHPAQKVSVDLGRLGPDAVTVGAAILPLADFFGRGGRRLEPAPEGPAPAWRTALEERAPH
>CP022744.1|AXG58814.1|9187035_9187350_+|hypothetical-protein
MAAHRSEGPGENGAPIPRDLPDQQAHDGEDPWEVGDGRAQGDTVDSTEAADTTAAERAGDSEPEGTEDADADVPDTDESGTGRRGAPRSGAVHEEHPVPDEPSA
>CP022744.1|AXG58815.1|9187374_9188403_-|hypothetical-protein
MSTSAGSRIVVTGATGNVGTSLVRLLSEDPEVESVRGLARRIPDWSPRKTEWSAVDLASEQADLVKEFEGAAAVVHLAWAFQPTHDPATTWRTNVLGSMRVFDAVAAAGVPTLVHASSVGAYSPGPKGHAVDESWPTHGWPDAAYCREKAYLERALDTFERDRPGVRVVRMRPAFLFKRESASEQRRIFGGRFLPGPLARPELLPFLPDIPGLRVQALHTDDAADAYRLAVHSDVRGAFNLAGEPPVDAELLGEMLGARPVRLPRAAARSAIAAAWGLHLLPASPHLFDAVLRLPLMDCTRARAELRWRPEHTATEVLEEFLQGMQQGAGARTEPMRGRKVG
>CP022744.1|AXG58816.1|9188470_9189139_+|dipeptidase
MSEIILMSDARVAAVAVEECGEPLVDVSGSLLVDDRKYKDSLGAETHLRRGVLERLLRAQSLLPDGLRLLFVEGYRPPALQRRYFERYADELRAAHPQWAADRIRTAASRYVSPPEIAPHTAGAAVDLTLADADGRELDLGTAMNASPEESGGACYTDAAGISEEARENRAVLGRALGAAGLVNYPTEWWHWSYGDRYWALATGAAVAPYGPKELEAQEAGA
>CP022744.1|AXG58817.1|9189142_9189832_-|hypothetical-protein
MGDDFAVSEKRPNAAAQAITAVVLIGGIGAALWGLDPRETQAADEPATCSPASTAESRPSGNVSGDQLCTALNRPDLATLLGTPTEKAKTAGGSDSYFTSGDGTKTATPSGEVTFETYTVKLSATYDGLAVAEEGEYLGRTAEPRTVLGRPAVLYTTQTIALRFNLGGGDSESGPGVPARSLVIAQTARDRGGSFELTVFREDGMPPDDEALLRVAEQVLPTIPGWNKA
>CP022744.1|AXG58818.1|9189919_9190882_-|oxidoreductase
MSTAQHKIGSGFGATSTADEVLAGIDLTGRLAVVTGGYSGLGLETTRSLTKAGARVVVPARRPDTAREALEGIDGVEVDELDLGDLESVRAFAERFLASDRTIDLMIDNAGIMACPETRVGPGWEAQFATNHLGHFALVNRLWPAIAPGGARVVSVSSRGHHFSGIRWDDLHWARGYDKWQAYGQAKTANVLFAVHLDRLARDAGVRAFSLHPGGIMTPLQRHLSQAEMIERGWIDEHGTLLTPELFKSPEQGAATQVWAATSPQLAGMGGVYLEDCDIAEPAAPDDERSGVRAWAVDPGQAARLWEVSAELTGVNAFAA

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

81162 : 114780

Catovirus(25.0%)

transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG51222.1\|81162_81810_-\|transposase	putative IS701 family ISMmq4-like transposase	NA	NA	NA	NA
AXG51223.1\|82280_82478_+\|transposase	transposase	NA	NA	NA	NA
AXG51224.1\|82550_83021_-	hypothetical protein	NA	NA	NA	NA
AXG51225.1\|84719_87659_-	hypothetical protein	NA	NA	NA	NA
AXG51226.1\|87661_89500_-	HSP90 family protein	A0A1V0SAD6	Catovirus	9.3e-18	21.6
AXG51227.1\|89587_90580_-	hypothetical protein	NA	NA	NA	NA
AXG51228.1\|91891_92101_-	hypothetical protein	NA	NA	NA	NA
AXG51229.1\|92440_92554_-\|transposase	IS110 family transposase	NA	NA	NA	NA
AXG51230.1\|92643_93216_+	hypothetical protein	H9EB19	Vibrio_phage	8.4e-10	42.5
AXG51231.1\|93307_95032_+	putative acyl-CoA dehydrogenase	NA	NA	NA	NA
AXG51232.1\|96526_99538_-	secreted protein	NA	NA	NA	NA
AXG51233.1\|100239_101445_-	major facilitator superfamily permease	NA	NA	NA	NA
AXG51234.1\|101851_103270_+	putative DEAD/DEAH box helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	1.9e-39	29.3
AXG51235.1\|103407_104292_-\|transposase	transposase	NA	NA	NA	NA
AXG51236.1\|104422_105724_-\|transposase	transposase mutator family protein	NA	NA	NA	NA
AXG51237.1\|107796_108909_-	NADH:flavin oxidoreductase	NA	NA	NA	NA
AXG51238.1\|109393_110740_-	aldehyde dehydrogenase	NA	NA	NA	NA
AXG51239.1\|110913_111834_+	DNA-binding protein	NA	NA	NA	NA
AXG51240.1\|112837_113491_+	short-chain dehydrogenase/reductase SDR	NA	NA	NA	NA
AXG51241.1\|114309_114780_-\|transposase	transposase	Q716C2	Shigella_phage	2.7e-14	38.2

DBSCAN-SWA_2

121208 : 192587

Shigella_phage(16.67%)

integrase,transposase

attL 119690:119706|attR 179419:179435

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
119690:119706	attL	NA	NA	NA	NA
AXG51247.1\|121208_121640_+\|transposase	putative transposase	NA	NA	NA	NA
AXG51248.1\|121671_122064_+\|transposase	putative transposase	NA	NA	NA	NA
AXG51249.1\|122684_124112_+	hypothetical protein	NA	NA	NA	NA
AXG51250.1\|124586_125150_+	hypothetical protein	NA	NA	NA	NA
AXG51251.1\|125247_125805_-	hypothetical protein	NA	NA	NA	NA
AXG51252.1\|125808_126297_-	putative telomere-associated protein	NA	NA	NA	NA
AXG51253.1\|126522_126837_+	hypothetical protein	NA	NA	NA	NA
AXG51254.1\|129773_130817_-	luciferase family protein	NA	NA	NA	NA
AXG51255.1\|131118_133806_-	hypothetical protein	NA	NA	NA	NA
AXG51256.1\|134271_134574_+\|transposase	transposase	NA	NA	NA	NA
AXG51257.1\|134594_135401_+\|transposase	putative transposase	U5P429	Shigella_phage	4.3e-36	37.0
AXG51258.1\|135467_136496_-	AraC family transcriptional regulator	NA	NA	NA	NA
AXG51259.1\|136578_137415_+	hypothetical protein	NA	NA	NA	NA
AXG51260.1\|137616_138825_-\|transposase	transposase, IS605 OrfB	A0A0R8V9X2	Thermobifida_phage	5.8e-154	76.2
AXG51261.1\|138986_139415_+	Pyridoxamine 5'-phosphate oxidase	NA	NA	NA	NA
AXG51262.1\|140908_141589_-	hypothetical protein	NA	NA	NA	NA
AXG51263.1\|141773_142997_-\|transposase	IS200-like transposase	A0A068A1P5	Thermus_phage	4.2e-59	37.3
AXG51264.1\|143114_143468_+\|transposase	IS200-like transposase	I4AZM1	Saccharomonospora_phage	9.3e-36	62.1
AXG51265.1\|144455_145154_+	hypothetical protein	NA	NA	NA	NA
AXG51266.1\|145187_145394_-\|transposase	transposase	NA	NA	NA	NA
AXG51267.1\|145523_146297_-	hypothetical protein	NA	NA	NA	NA
AXG51268.1\|147539_147860_-	hypothetical protein	NA	NA	NA	NA
AXG51269.1\|148068_148284_-	hypothetical protein	NA	NA	NA	NA
AXG51270.1\|149849_151094_+	hypothetical protein	NA	NA	NA	NA
AXG51271.1\|151222_152056_+	hypothetical protein	NA	NA	NA	NA
AXG51272.1\|152398_152713_+	hypothetical protein	NA	NA	NA	NA
AXG51273.1\|154568_156332_+	amine oxidase	NA	NA	NA	NA
AXG51274.1\|156833_158393_+	hypothetical protein	NA	NA	NA	NA
AXG51275.1\|158468_161291_+	putative ATPase	NA	NA	NA	NA
AXG51276.1\|161442_162063_-	methyltransferase type 12	NA	NA	NA	NA
AXG51277.1\|162731_162845_-\|integrase	integrase	NA	NA	NA	NA
AXG51278.1\|163856_164111_+\|transposase	transposase IS4 family protein	NA	NA	NA	NA
AXG51279.1\|164168_164720_-	acetyltransferase	NA	NA	NA	NA
AXG51280.1\|164719_165556_-	hypothetical protein	NA	NA	NA	NA
AXG51281.1\|165611_167147_-	hypothetical protein	NA	NA	NA	NA
AXG51282.1\|167435_168437_-	secreted cellulose binding protein	NA	NA	NA	NA
AXG51283.1\|170742_171054_-	hypothetical protein	NA	NA	NA	NA
AXG51284.1\|171346_172468_+\|transposase	IS630 family transposase	NA	NA	NA	NA
AXG51285.1\|172468_172966_-	hypothetical protein	NA	NA	NA	NA
AXG51286.1\|174207_174924_+	dehydrogenase	NA	NA	NA	NA
AXG51287.1\|175368_175761_+\|transposase	transposase	NA	NA	NA	NA
AXG51288.1\|176318_177401_+	hypothetical protein	NA	NA	NA	NA
AXG51289.1\|178138_179647_-	BNR/Asp-box repeat-containing protein	NA	NA	NA	NA
179419:179435	attR	NA	NA	NA	NA
AXG51290.1\|179921_180389_-\|transposase	transposase	NA	NA	NA	NA
AXG51291.1\|181227_181377_+	methylase involved in ubiquinone/menaquinone biosynthesis	NA	NA	NA	NA
AXG51292.1\|181451_181775_-\|transposase	transposase	NA	NA	NA	NA
AXG51293.1\|182067_183009_-	beta-lactamase	NA	NA	NA	NA
AXG51294.1\|183005_183908_-	transcriptional regulator, LysR family protein	NA	NA	NA	NA
AXG51295.1\|184053_184995_+	putative beta-lactamase	A0A1B0VBP7	Salmonella_phage	3.0e-49	42.3
AXG51296.1\|185076_185259_+\|transposase	transposase IS4 family protein	NA	NA	NA	NA
AXG51297.1\|186289_187273_-	putative acetyltransferase	NA	NA	NA	NA
AXG51298.1\|187340_188336_-\|transposase	IS6120-like transposase	A0A2P1JQX9	Mycobacterium_phage	1.1e-70	70.0
AXG51299.1\|189478_190570_+\|transposase	transposase	NA	NA	NA	NA
AXG51300.1\|190791_191259_+	putative ribosomal protein S1-like protein	NA	NA	NA	NA
AXG51301.1\|191393_192587_-\|transposase	transposase	NA	NA	NA	NA

DBSCAN-SWA_3

2566255 : 2643736

Saccharomonospora_phage(12.5%)

protease,integrase,transposase

attL 2570987:2571006|attR 2589381:2589400

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG53270.1\|2566255_2566951_+\|transposase	putative transposase	NA	NA	NA	NA
AXG53271.1\|2567655_2567892_-\|transposase	transposase	NA	NA	NA	NA
AXG53272.1\|2568604_2568973_+	hypothetical protein	NA	NA	NA	NA
AXG53273.1\|2568984_2569722_+	hypothetical protein	NA	NA	NA	NA
AXG53274.1\|2570201_2571653_+	hypothetical protein	NA	NA	NA	NA
2570987:2571006	attL	NA	NA	NA	NA
AXG53275.1\|2571716_2572805_-\|integrase	traSA integrase fusion protein	Q8LTU1	Saccharomonospora_phage	5.5e-18	24.1
AXG53276.1\|2573303_2573834_-\|integrase	phage integrase family protein	NA	NA	NA	NA
AXG53277.1\|2574646_2577943_-	N-6 DNA methylase	NA	NA	NA	NA
AXG53278.1\|2578388_2583110_+	protein kinase	NA	NA	NA	NA
AXG53279.1\|2583163_2586922_+	DNA methylase	NA	NA	NA	NA
AXG53280.1\|2586948_2590842_+	pglY	NA	NA	NA	NA
2589381:2589400	attR	NA	NA	NA	NA
AXG53281.1\|2590841_2593763_+	putative bacteriophage resistance gene pglZ	NA	NA	NA	NA
AXG53282.1\|2593833_2595186_+	ATP/GTP binding protein	NA	NA	NA	NA
AXG53283.1\|2595254_2597411_+	ATP-dependent helicase	NA	NA	NA	NA
AXG53284.1\|2597943_2598954_+	hypothetical protein	NA	NA	NA	NA
AXG53285.1\|2599109_2602259_+	hypothetical protein	NA	NA	NA	NA
AXG53286.1\|2602258_2604880_+	hypothetical protein	NA	NA	NA	NA
AXG53287.1\|2605186_2606575_-	RNA methyltransferase	A0A1X9I6F4	Streptococcus_phage	9.1e-26	26.1
AXG53288.1\|2606678_2608766_-	amino acid permease	NA	NA	NA	NA
AXG53289.1\|2609129_2609801_+	potassium transporter	NA	NA	NA	NA
AXG53290.1\|2609800_2610478_+	potassium transporter	NA	NA	NA	NA
AXG53291.1\|2610592_2611345_-	hypothetical protein	NA	NA	NA	NA
AXG53292.1\|2611348_2611747_-	hypothetical protein	NA	NA	NA	NA
AXG53293.1\|2611792_2612509_-	two-component system response regulator for high-affinity potassium transport system	W8CYM9	Bacillus_phage	5.2e-25	30.4
AXG53294.1\|2612502_2615052_-	osmosensitive K+ channel histidine kinase	A0A2K9L0Z8	Tupanvirus	3.4e-10	27.1
AXG53295.1\|2615434_2616142_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	8.4e-36	36.2
AXG53296.1\|2616203_2617370_-	secreted protein	NA	NA	NA	NA
AXG53297.1\|2617554_2618325_-	hypothetical protein	NA	NA	NA	NA
AXG53298.1\|2618326_2618887_-	deoxyuridine 5'-triphosphate nucleotidohydrolase	A0A2L1IVN2	Streptomyces_phage	9.6e-35	55.8
AXG53300.1\|2618883_2619468_-	hypothetical protein	NA	NA	NA	NA
AXG53299.1\|2619525_2619990_+	secreted protein	NA	NA	NA	NA
AXG53301.1\|2620109_2621021_-	hypothetical protein	NA	NA	NA	NA
AXG53302.1\|2621034_2621331_-	hypothetical protein	NA	NA	NA	NA
AXG53303.1\|2621736_2622861_-	two-component system sensor kinase	NA	NA	NA	NA
AXG53305.1\|2622994_2623648_-	two-component regulator	NA	NA	NA	NA
AXG53304.1\|2624063_2624237_+	hypothetical protein	NA	NA	NA	NA
AXG53306.1\|2624318_2625134_-	SuhB protein	NA	NA	NA	NA
AXG53307.1\|2625142_2626270_-	ferrochelatase	NA	NA	NA	NA
AXG53308.1\|2626467_2627706_+	transmembrane efflux protein	NA	NA	NA	NA
AXG53309.1\|2627665_2628985_+	FAD-dependent oxidoreductase	NA	NA	NA	NA
AXG53310.1\|2629436_2630498_+	DNA-binding protein	NA	NA	NA	NA
AXG53311.1\|2630656_2631508_-	thiosulfate sulfurtransferase	NA	NA	NA	NA
AXG53312.1\|2631877_2632696_+	hydroxylase	NA	NA	NA	NA
AXG53313.1\|2632771_2633419_-	thymidine kinase	C1KFH3	Lactobacillus_virus	1.7e-30	41.1
AXG53314.1\|2633467_2634670_-	phosphodiesterase	NA	NA	NA	NA
AXG53315.1\|2634669_2635257_-	hypothetical protein	NA	NA	NA	NA
AXG53316.1\|2635340_2638205_-	acyl-CoA synthetase (NDP forming type)	NA	NA	NA	NA
AXG53317.1\|2638431_2638713_+	phosphocarrier protein	NA	NA	NA	NA
AXG53318.1\|2638929_2639625_-	GntR-family transcriptional regulator	NA	NA	NA	NA
AXG53319.1\|2639811_2640585_-	hypothetical protein	A0A1P8BKT8	Lactococcus_phage	3.2e-12	45.2
AXG53320.1\|2640950_2642339_-\|protease	protease	NA	NA	NA	NA
AXG53321.1\|2642335_2643736_-\|protease	zinc protease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP022744

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection