CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP031188	Flavobacterium arcticum strain SM1502 chromosome, complete genome	1 crisprs	DEDDh,cas3,WYL,DinG,csa3	0	0	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP031188_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP031188_1

1505651-1505746

Orphan

Consensus_repeat	Method
AATAAAAGAGAAAACAAAAAGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP031188_1

>merge|CP031188|1|1505651-1505746|CRISPRCasFinder
AATAAAAGAGGAACAAAAAGAAGTAACGAAAGAAACAATAAAAGAGAAAACAAAAAGAAGTAACGAAAGAAACAATAAAAGAGGAACAAAAAGAAG

>CP031188|1|1|1505651-1505746|CRISPRCasFinder
AATAAAAGAGGAACAAAAAGAAG	TAACGAAAGAAACAATAAAAGAGAAAACAAAAAGAAGTAACGAAAGAAAC
AATAAAAGAGGAACAAAAAGAAG

Protein	Signature genes	Signature genes Name	Protein_function
CP031188.1\|AXG73978.1\|1510988_1512149_+\|4-hydroxyphenylpyruvate-dioxygenase	unknown	unknown	gnl\|CDD\|273528
CP031188.1\|AXG73977.1\|1509706_1510864_+\|homogentisate-1,2-dioxygenase	unknown	unknown	gnl\|CDD\|226039
CP031188.1\|AXG75237.1\|1495629_1496154_-\|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl\|CDD\|239264
CP031188.1\|AXG73972.1\|1500329_1500905_-\|5-formyltetrahydrofolate-cyclo-ligase	unknown	unknown	gnl\|CDD\|274270
CP031188.1\|AXG73969.1\|1498467_1498773_+\|TIGR03643-family-protein	unknown	unknown	gnl\|CDD\|378528
CP031188.1\|AXG73982.1\|1517689_1518160_+\|CYTH-domain-containing-protein	unknown	unknown	gnl\|CDD\|143629
CP031188.1\|AXG73968.1\|1497190_1498486_+\|DASH-family-cryptochrome	unknown	unknown	gnl\|CDD\|274288
CP031188.1\|AXG73975.1\|1506081_1507050_+\|succinylglutamate-desuccinylase	unknown	unknown	gnl\|CDD\|349469
CP031188.1\|AXG75238.1\|1512452_1513214_+\|DUF3108-domain-containing-protein	unknown	unknown	gnl\|CDD\|378635
CP031188.1\|AXG73970.1\|1498871_1499561_+\|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|379263
CP031188.1\|AXG73966.1\|1494856_1495618_-\|thioredoxin-family-protein	unknown	unknown	gnl\|CDD\|239267
CP031188.1\|AXG73967.1\|1496500_1496860_+\|hypothetical-protein	unknown	unknown	unknown
CP031188.1\|AXG73971.1\|1499891_1500302_-\|hypothetical-protein	unknown	unknown	unknown
CP031188.1\|AXG73981.1\|1517269_1517539_-\|hypothetical-protein	unknown	unknown	unknown
CP031188.1\|AXG73976.1\|1507327_1509142_-\|sodium:calcium-symporter	unknown	unknown	gnl\|CDD\|271365
CP031188.1\|AXG73974.1\|1503162_1504959_-\|excinuclease-ABC-subunit-UvrC	unknown	unknown	gnl\|CDD\|234792
CP031188.1\|AXG73980.1\|1515418_1517062_+\|glucose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|234679
CP031188.1\|AXG73973.1\|1500955_1503163_-\|patatin	unknown	unknown	gnl\|CDD\|132844
CP031188.1\|AXG73979.1\|1514171_1515416_+\|M23-family-peptidase	unknown	unknown	gnl\|CDD\|236946
CP031188.1\|AXG75239.1\|1513243_1514158_+\|tryptophan-2,3-dioxygenase	unknown	unknown	gnl\|CDD\|226014

Protein	Function_ID	Function_description	E-value
CP031188.1\|AXG73977.1\|1509706_1510864_+\|homogentisate-1,2-dioxygenase	gnl\|CDD\|226039	COG3508, HmgA, Homogentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism].	6.20436e-69
CP031188.1\|AXG75237.1\|1495629_1496154_-\|TlpA-family-protein-disulfide-reductase	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	9.61802e-20
CP031188.1\|AXG73972.1\|1500329_1500905_-\|5-formyltetrahydrofolate-cyclo-ligase	gnl\|CDD\|274270	TIGR02727, Uncharacterized_protein_YqgN, 5,10-methenyltetrahydrofolate synthetase. This enzyme, 5,10-methenyltetrahydrofolate synthetase, is also called 5-formyltetrahydrofolate cycloligase. Function of bacterial proteins in this family was inferred originally from the known activity of eukaryotic homologs. Recently, activity was shown explicitly for the member from Mycoplasma pneumonia. Members of this family from alpha- and gamma-proteobacteria, designated ygfA, are often found in an operon with 6S structural RNA, and show a similar pattern of high expression during stationary phase. The function may be to deplete folate to slow 1-carbon biosynthetic metabolism. [Central intermediary metabolism, One-carbon metabolism].	1.18322e-43
CP031188.1\|AXG73969.1\|1498467_1498773_+\|TIGR03643-family-protein	gnl\|CDD\|378528	pfam10985, DUF2805, Protein of unknown function (DUF2805). This is a bacterial family of proteins with unknown function.	1.11349e-36
CP031188.1\|AXG73982.1\|1517689_1518160_+\|CYTH-domain-containing-protein	gnl\|CDD\|143629	cd07891, CYTH-like_CthTTM-like_1, CYTH-like Clostridium thermocellum TTM-like subgroup 1. This subgroup contains the triphosphate tunnel metalloenzyme (TTM) from Clostridium thermocellum (CthTTM) and similar proteins. These are found primarily in bacteria. CthTTM is a metal dependent tripolyphosphatase, nucleoside triphosphatase, and nucleoside tetraphosphatase. It hydrolyzes the beta-gamma phosphoanhydride linkage of triphosphate-containing substrates including tripolyphosphate, nucleoside triphosphates and nucleoside tetraphosphates. These substrates are hydrolyzed, releasing Pi. Mg++ or Mn++ are required for the enzyme's activity. CthTTM appears to have no adenylate cyclase activity. This subgroup consists chiefly of bacterial sequences. These enzymes are members of the CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) superfamily, which have a unique active site located within an eight-stranded beta barrel.	5.52583e-81
CP031188.1\|AXG73968.1\|1497190_1498486_+\|DASH-family-cryptochrome	gnl\|CDD\|274288	TIGR02765, deoxyribodipyrimidine_photolyase, cryptochrome, DASH family. Photolyases and cryptochromes are related flavoproteins. Photolyases harness the energy of blue light to repair DNA damage by removing pyrimidine dimers. Cryptochromes do not repair DNA and are presumed to act instead in some other (possibly unknown) process such as entraining circadian rhythms. This model describes the cryptochrome DASH subfamily, one of at least five major subfamilies, which is found in plants, animals, marine bacteria, etc. Members of this family bind both folate and FAD. They may show weak photolyase activity in vitro but have not been shown to affect DNA repair in vivo. Rather, DASH family cryptochromes have been shown to bind RNA (Vibrio cholerae VC1814), or DNA, and seem likely to act in light-responsive regulatory processes. [Cellular processes, Adaptations to atypical conditions].	0
CP031188.1\|AXG73975.1\|1506081_1507050_+\|succinylglutamate-desuccinylase	gnl\|CDD\|349469	cd06251, M14_ASTE_ASPA-like, Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup. A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.	4.532e-76
CP031188.1\|AXG75238.1\|1512452_1513214_+\|DUF3108-domain-containing-protein	gnl\|CDD\|378635	pfam11306, DUF3108, Protein of unknown function (DUF3108). This is a bacterial family of putative lipoproteins. Structure 3fzx, the first structural template for this large family including several homologs in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Bacteroides fragilis glyA is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA\|QNQDC, and a Phobius server prediction of non-cytoplasmic localization for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit Structure 2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.	2.8711e-71
CP031188.1\|AXG73976.1\|1507327_1509142_-\|sodium:calcium-symporter	gnl\|CDD\|271365	cd10333, LeuT-like_sbd, Aquifex aeolicus LeuT and related proteins; solute binding domain. LeuT is a bacterial amino acid transporter with specificity for the hydrophobic amino acids glycine, alanine, methionine, and leucine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family; LeuT has been used as a structural template for understanding fundamental aspects of SLC6 function. It has an arrangement of 12 transmembrane helices (TMs), which appears to be a common motif for eukaryotic and some prokaryotic and archaeal SLC6s: an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12.	0
CP031188.1\|AXG73966.1\|1494856_1495618_-\|thioredoxin-family-protein	gnl\|CDD\|239267	cd02969, PRX_like1, Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic cysteine found in PRXs, which aligns to the second cysteine in the CXXC motif of TRX. In addition, these proteins do not contain the other two conserved residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF.	6.68203e-62
CP031188.1\|AXG73978.1\|1510988_1512149_+\|4-hydroxyphenylpyruvate-dioxygenase	gnl\|CDD\|273528	TIGR01263, 4-hydroxyphenylpyruvate_dioxygenase, 4-hydroxyphenylpyruvate dioxygenase. This protein oxidizes 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerization into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously in blood and is hemolytic (see . In some bacterial species, this enzyme has been studied as a hemolysin. [Energy metabolism, Amino acids and amines].	8.83805e-162
CP031188.1\|AXG73980.1\|1515418_1517062_+\|glucose-6-phosphate-isomerase	gnl\|CDD\|234679	PRK00179, pgi, glucose-6-phosphate isomerase; Reviewed.	0
CP031188.1\|AXG73970.1\|1498871_1499561_+\|SDR-family-NAD(P)-dependent-oxidoreductase	gnl\|CDD\|379263	pfam13561, adh_short_C2, Enoyl-(Acyl carrier protein) reductase.	4.84213e-40
CP031188.1\|AXG73974.1\|1503162_1504959_-\|excinuclease-ABC-subunit-UvrC	gnl\|CDD\|234792	PRK00558, uvrC, excinuclease ABC subunit UvrC.	0
CP031188.1\|AXG73973.1\|1500955_1503163_-\|patatin	gnl\|CDD\|132844	cd07205, Pat_PNPLA6_PNPLA7_NTE1_like, Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1. Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are included in this family. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologus to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes subfamily of PNPLA6 (NTE) and PNPLA7 (NRE)-like phospholipases.	3.33094e-64
CP031188.1\|AXG73979.1\|1514171_1515416_+\|M23-family-peptidase	gnl\|CDD\|236946	PRK11649, PRK11649, putative peptidase; Provisional.	4.12122e-58
CP031188.1\|AXG75239.1\|1513243_1514158_+\|tryptophan-2,3-dioxygenase	gnl\|CDD\|226014	COG3483, TDO2, Tryptophan 2,3-dioxygenase (vermilion) [Amino acid transport and metabolism].	2.40668e-26

>CP031188.1|AXG73974.1|1503162_1504959_-|excinuclease-ABC-subunit-UvrC
MQTPLELQIQTLPDSPGVYQYFDKDDKLLYVGKAKNLKKRVMSYFNKTNDSGRIRVMVRKIVRVKHIVVPTESEALLLENNLIKNLQPRYNVLLKDDKSYPWICIKKEPFSRVFATRNVIKDGSEYFGPYTSFKTVQTLLGLIKELYPLRTCNYDLSKSNIQSGKYKVCLEYHIGNCKGPCEGYEPLEEYQRHVAAIREILKGNFKESLKAFHSHMHNLAADMKFEEAQEIKEKIEALENYQARSTVFNPRINNLDVFSIISDEAMAYINFIQVSHGAIIRSHTMEIKKKLEESDEELLQIAAVELRERFQLLSREVLATHPINLGENVKVTVPKLGDKKQILDLSERNARFYRMDQLKQIKIVDPERHTNRIMAQMKKDLRLPAEPRHIECFDNSNIQGTNPVAACVVFKDGKPSKKDYRHFNIKTVEGPNDFASMEEVVFRRYRRLLEEDQPLPQLIIIDGGKGQLSSALKSLDILGLRGKITILGIAKRLEEIFYPGDSIPMYLDKKSETLKVIQHLRNEAHRFGITHHRDKRSKNALQTSVESIPGIGEKTMVALLKQFKSVKRLKEAPEADIAKVIGPAKAKKITEFYHSKPN
>CP031188.1|AXG73973.1|1500955_1503163_-|patatin
MKKILPLLLCLLLIGTVTAQEENSANTNTKRPKIGVVLSGGGAKGLAHIGVLKVLEEAGIKVDYIGGTSMGAIVGGLYAAGYSAQELDSIFNSLDADALIQDYTPRGSKNFFERRNDELYALSLPFKGFKISFPTALSKGLYNYTTVNRLTDNVRHQRDFNKLPIPFVCVATDIETGEEIILHKGVLPDAILASGAFPSLYYPVEIDGRLLIDGGVTNNYPVEEVKKMGADIIIGVDVQDGLKDRTQIKGATGVLVQINNYQMIRKMDAKREATDIYIKPDISGYTVISFDDGRQIIDKGEEAAHAIIDKLKALGSNTPIVKKAMQVNDSIAVAEIEISGLKNYSRAYVIGKLNFKPGTKISYEKFNRGISNLNATQNFNAISYNFEKTGKGDRLNLTIIENPINRYLKFGLHYDGLYKSGVLVNFTQKNLFRRGDVAALDVVLGDNFRYMFNYYMDNGFYTSYGVRSTLNSFNRNVPGNIISDIDVNSANVDYTDINNQIYIQTIFAQKFLLGGGAELKHLKIKSETLSTDRKKVFDDSDYFSVYGYLNYDSYNKRYFPSKGWYFQGEAKSFLYSSDYNKDFERFTILKAEIATAKKIYRNFTIEMQTEAGITVGEDTANFFDFILGGYGYNTINNFRHFYGYDFISLSGNSYIKSTFTLDWEFIRKHHLNATANYANVGHNLLNEGNIISLPEYTGYAMGYGMESIIGPLEIKHSWSPDTNKHYTWISVGFWF
>CP031188.1|AXG73972.1|1500329_1500905_-|5-formyltetrahydrofolate-cyclo-ligase
MTKQEIRAKYRALRKGLTTAEVETQSLAIANKLLQLPVWDKTYYHLFLSIEEQKEVQTEFVLHILSGKDKEIVVAKSDFENFGMTHYLLTDNTKLAKNQYGIPEPIDGLEVPSIKLDVVFIPLLAFDNNGNRLGYGKGFYDRFLAECRSDVVKIGLSFFESETETLPNSDTDIALDYCVTPQKVYQFNKQH
>CP031188.1|AXG73971.1|1499891_1500302_-|hypothetical-protein
MEKHLLLSDEEFIKEFENCSLNPEVFSHEAHLRLAWIYLCKYNEAMAYRKTVVNLKAYIKHLGAEGKFNHTLTIASVKAVYHFMQRSQYANFTDFINEFPELKYNLKELLATHYSIDIFNLPEAKTHWLEPDLSAF
>CP031188.1|AXG73970.1|1498871_1499561_+|SDR-family-NAD(P)-dependent-oxidoreductase
MATYIFAGASSGMAMQAATLLQEQGHKVIGVSTKEDTGNYNQWYKVQEYGFGAFPAIDAEIDGLVYFPGTINLKPFHRINENDFTTDFTISALGAAAFVQAYLPQLKKSAIASIVFISTVAVGTGMPFHASVAMAKGAVEGLTRSLAAEYAPKVRVNCVAPSLTDTPLAGRLLASEDKMEAAKNRNPLKKIGTPNDLAQAITFLLGANAAWVTGQVLAVDGGMNKLRLL
>CP031188.1|AXG73969.1|1498467_1498773_+|TIGR03643-family-protein
MATRSIAIKETSDLTERDIDRIIEMAWEDRTPFDAIEYQFSLTEDKVKELMKRELKFSSYRLWRKRVESCKTKHAKKRSDAIDRFKCSRQRAISSNKIAKR
>CP031188.1|AXG73968.1|1497190_1498486_+|DASH-family-cryptochrome
MPTSIVWFKTDLRLHDNEALVKAIQQNNSVVPVFCIDDDQFGKTKFGFEKTGSFRAQFLLESLADLDTQLRKLKSGLVIVRGIPEEELPRVARLYNAKKVYAKKEVTTDEKKQEERVVAALWKQGCMVETFSTSTLYHAEDLPFPLRGIPDVFTTFRKKIEKEAGIRPVFHKPDSIPSPIIPLMELPSLEELGLEEIALDSRAAITFKGGETEGLKRLNDYIFKTEAIATYKETRNGLLGKNYSSKFSPWLAMGCLSPREVYHEVKKYEAKNGANKSTYWMIFELLWRDYFRFMMKKHRNKLFLSGGIKNIAPKLSKPNAEVLQRWINGETGQDFIDANMRELKLTGFMSNRGRQNVASYLCHELDTDWRYGAAYFEEILIDYDPSSNWGNWAYIAGVGNDPRVERHFDPQKQADDYDAKKTYRDLWLQEA
>CP031188.1|AXG73967.1|1496500_1496860_+|hypothetical-protein
MKKITIILATLFTTLIYAQASEEMICDGNVSYAVKKNGEIRYIAVTDDNISFIAGTIGTDEISYYASLTYVGGDKPVVRKKGTKINLQNGNIISKPDVEIKVDVNDKAEFEYKAFVPLT
>CP031188.1|AXG75237.1|1495629_1496154_-|TlpA-family-protein-disulfide-reductase
MRHLLCLGLLFSFCISCKNKEAKVITEVKNVSEINNNIPVYDFNTLEPLFYTKTDKTYIINFWAMWCGPCVEELPYIEEYAAKNPDVEVLLISLDFPKDIETKLKPFLKKKNITSKVILLDDPDANAWIDKIDPHWSGSIPFTIIFNSKKRAFFEHAFTSTKELENTVTETLKQ
>CP031188.1|AXG73966.1|1494856_1495618_-|thioredoxin-family-protein
MKKLILCIAAVGLLSTVAISCKDKAEQKTDVTAENNNNPEREEHPEGDHKRPPHDGDRKGPPGGHGPEQTKTLEEIGGYKIGEVATDFSLKNIDGSMFSLADIDNAKGYIVTFTCNECPFAKMYEDRLIELHNTYAPKGYSVIAINPNSPENEKEGYKAMQKRAKEKGFPFPYLVDQGQKIYPQYGAVRTPHVFLLDKDRKVQYIGTIDDNAKSTEDVKVKYLENAIKALENGEKPSPNLTKAIGCPVKASKA
>CP031188.1|AXG73975.1|1506081_1507050_+|succinylglutamate-desuccinylase
MSYKNITILGETILPGESKTINMEIARLHTMTKLKVPIIIERAEEDGPVVLFTASIHGDEINGTEIVRQLIVRKINKPKRGTIICIPVVNIFGFVNKSREFPDGRDLNRVFPGSQRGSLAGRFAWHLFREIIPNVDYCIDYHAGGASRFNAPQIRIVPNNPDLKALADVFNAPFTLYSKNISGSFRNACGRLGVKILLYEGGKSLDLNRDVTQAAVRGTKRFLNHLDMLNPKKKFKPAPTPSVYIERSAWVRATYSGLFQNRTPTGKLVEKGEAIALITDPFGDFEHVVKAPHRGYIINSNDAPIVYQGDAIFHITMKLTEQ
>CP031188.1|AXG73976.1|1507327_1509142_-|sodium:calcium-symporter
MSGKAESWGSRVGLILAMAGNAVGLGNFLRFPVQAVENGGGAFIIPYLVCFVVMGIPLLFIEWSTGRYGGRYGNHSTPYILDTMAKGRIWKYIGVFGIFTNIAVASYYCYIESWTMSYVYHSVRGTFSTMNQAEIAGFFNDYTTIGKSTTGIPYEAIVFYILCLLLNTFILSKGLKGIERVAKIGIPLLLVFGAILAIRGLTLGTDGASDLFPDANAWDGLNFLWTPQYDSLANPKVWLAAAGQIFFTLSVGMGTIHCYAAYLKSKDDVALNAVSAGFMNEFVEVVLGSLIVIPIAAGYLGLDWVLQNAGFGMAFQTMPYLFQQWGETLAIFAGIFWFGLLFFAGITSSLAMGTPWMGFMRDEFNWSGKKGAWSFGLIALIMGLPTVFFFQQGVFDEYDYWAGTVSLVVFAFLETVLFSWIFGIKKGWAEINMGADIKVPIFFKYLILVVTPLLLGWVLVASLPDMAAKIANDDTNNKEWFADAYYAEKFDSEGLKTGVVDSVTTDFIKLSFQNEKKVYNKKLDKLEALTFTDYKTYSFKKGQNPVVTVGQTIAPNDTIAEGKFTNNVFYKTIGRLLLVALLLFISLVVYRAFIKRRKEGRVHS
>CP031188.1|AXG73977.1|1509706_1510864_+|homogentisate-1,2-dioxygenase
MPIYHKLGKFPQKRHTQFEKPEGGIYYEQLFGTEGFNGHSSLLYQVHRPTQVKEILRSYSVKPEIAIESNIKSLLLKGFEVQPADDFLESRVDMLVNSDCTIGLAAPRKSLRDYFYKNADADEMIFIHKGTGTLRTFMGNIPFEYGDYLIIPRGMIYQIDFDTEENRLFYTESVAPIYTPKRYKNESGQLLEHSPFCERDFKLPQELETYDEKGDFLIKVKKQGMMHEIVYATHPFDVVGWDGYNYPYAFSIHNFEPITGRVHLPPPIHQTFETSTFVVCSFCPRLYDYHPKSIPAPYNHSNIDSDEVLYYVDGDFMSRNNIEQGHITLHPKGIPHGPAPGATERSIGQTVTEELAVMVDTFRPLMVTKAAMGIDDGKYYKSWVE
>CP031188.1|AXG73978.1|1510988_1512149_+|4-hydroxyphenylpyruvate-dioxygenase
MSKEVKNVEYGLEKIFEGAQDFLPLMGTDYIEFIVGNAKQAAHYYKTAFGYQSLAYAGLETGMKDRTSYVLKQDKIRIVLTTPLTAESPLNDHIVKHGDGVKVVALWVEDARKSFEETTKRGARVYMEPTVETDEHGEVVRAGIYTYGETVHMFVERKNYNGVFLPGFREWKSDYNPAPTGLKYVDHMVGNVGWNEMNTWVKWYEEVMGFVNFLSFDDKQITTEYSALMSKVMSNGNGRIKFPINEPAEGKKRSQIEEYLDFYGGPGVQHIAIATDDIIKTVGELRARGVEFLSAPPHAYYEAIPERLGAHMDMMKEDISVLEDLAIMIDADEEGYLLQIFTKPVEDRPTLFYEIIQRMGARGFGAGNFKALFESIEREQQLRGTL
>CP031188.1|AXG75238.1|1512452_1513214_+|DUF3108-domain-containing-protein
MKKMLAILLLFTLGNAFSQGAFTTGEFFKFRIHYGIVNAGYATLEVKDAVKNGKKVYHVVGKGHTTGMTRFFFKVEDNYESYFDKNTVFPYQYVRKINEGGYTKDQEGFFNQKNNTVVVKDYKHDTEKTISVPAGVQDMVSTFYYLRNHPDVSTMKVGEYIAVNMFFDDETTKFKLKFIGRENISTKFGDVPAMIFRPYVQAGRVFKEEESLTVWISDDDNKIPLRIKASLAVGSLKADLIEYKGLKYPFKAK
>CP031188.1|AXG75239.1|1513243_1514158_+|tryptophan-2,3-dioxygenase
MQDKLSALEEKFKAINQKTETHLEGLLWSKPITYWDYIQTDALLNLQTQRTTLPDEMIFIMYHQVNELLFKMILWETEQLCHDDAPTTEIFTEKLMRISRYFDMLTTSFDIMGDGMQVEQYMKFRNTLTPASGFQSAQYRLIEFASTDLINLIDYRFRATIDRDTPYEHAFEHLYWQAAGKDHKTGEKSYLIKAFEKKYKAEFLRYMEEYNTINIWKKFQQLPEADQKNTMLVKAMRHYDYTVNVTWVMGHYNAAAKYIESASGPQEATGGSDWKKYMHPKYQRRIFFPELWTEEELRTWGENV
>CP031188.1|AXG73979.1|1514171_1515416_+|M23-family-peptidase
MPKLRYFTIILLLFTLIACNDEEKKDKEQQAVAKKEAVKKQFGFVLDNYEVEHDTIQNGDTFGGLLQKQGYSVTDVYNITEAIRDTFNLRDIRVGKPYTLLKNKKNPDSLEVFIYQANRLSYYVVDLRDSIAKAYKKTRPLTIKRRVIAAEIEGSLSATVQKLGASAALTQELSEIYAWSIDFFRLQKGDKFSVIINERYISDTIYAGLESIEAAVFETKDDKRYAFPYKQDPSARFSNYYDEEGKVLKSMFLKAPLKFSRISSRFSPRRFHPVQKRWKAHKGTDYAAPTGTPIMSTATGTVIAAGYTAGNGNYVKVKHNNTYTTQYLHMSKIKVRKGQHVNQGDIIGLVGSTGLATGPHVCYRFWKNGVQVDALRQKLPASQPMDAKYKPDFMKQMKPLKKELDSIYNITFNK
>CP031188.1|AXG73980.1|1515418_1517062_+|glucose-6-phosphate-isomerase
MALENTNPSGTAAWQELRAHFADMQQASMQDMFTADGSRSEKFHIKWNDFLVDYSKNIVNQKTLDLLQDLAKEVNLAGAMESYFAGEAINRTEGRAVLHTALRAPQSADIKVDGQNVMPEVYAAKNKIKQFTDEVISGSRKGYTGRAFTHVVNIGIGGSDLGPAMVVEALAYYQNQLEVRFISNVDGDHVMEKLKGLNPETTLFVIVSKTFTTQETLSNANTARAWFLEQATQDDVAKHFVAVSTNLKNVTEFGINPDNVFPMWDWVGGRFSLWSAVGLSVALAVGYDNFDKLLQGAHEMDEHFRTAPHEENIPVVLALLSIWYNNFFGAESEALIPYTQYLQKLAPYLQQGIMESNGKSVGRDGNPVNYQTGTIIWGEPGTNSQHAFFQLIHQGTKLIPTDFIGFIKPLHGNHDHHDKLMSNFFAQTEALLNGKTEAQVKAEFDVKGVTGEEADFLLPFKVFRGNKPTNTLLIDKLTPETLGSLVALYEHKIFVQGVIWNIFSYDQWGVELGKQLANSILGEINSGDVKQHDSSTTALLKAFLAKK
>CP031188.1|AXG73981.1|1517269_1517539_-|hypothetical-protein
MSEQEQFLNTIAEVLKPIESTIGPQSGISMQAMRNKLSNFTEVLEAKRTKVNEMANGYINTRNPSAEQVEDIKEQVNILFNNYMKSFNN
>CP031188.1|AXG73982.1|1517689_1518160_+|CYTH-domain-containing-protein
MNEIERKFLVLNNDYKTEAFSQKRITQGYLSSVPERTVRVRTKGDKGYLTVKGKSNESGTTRMEWETEITLAEAEQLLAICETGVIDKTRYEVKAGKHTFEVDEFYGDNEGLVIAEVELDDENETFVKPVWLGQEVTGDERYYNAYLSHKPYTTWK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

559410 : 568417

Tupanvirus(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG73161.1\|559410_560670_-	GTP-binding protein	A0A1V0SGC3	Hokovirus	7.7e-32	26.4
AXG73162.1\|560742_561648_-	sulfate adenylyltransferase subunit CysD	NA	NA	NA	NA
AXG73163.1\|561652_562249_-	adenylyl-sulfate kinase	A0A2P1ELS9	Moumouvirus	2.1e-27	43.6
AXG73164.1\|562245_562674_-	DUF2061 domain-containing protein	NA	NA	NA	NA
AXG73165.1\|562670_563465_-	3'(2'),5'-bisphosphate nucleotidase	NA	NA	NA	NA
AXG73166.1\|563638_564649_-	NAD-dependent epimerase	A0A2K9L4U8	Tupanvirus	8.1e-40	32.3
AXG73167.1\|564716_566108_-	UDP-glucose 6-dehydrogenase	A0A127AXI2	Bacillus_phage	1.6e-62	34.1
AXG73168.1\|566138_567410_-	nucleotide sugar dehydrogenase	M1HWZ1	Paramecium_bursaria_Chlorella_virus	7.8e-24	26.3
AXG75206.1\|567442_568417_-	NAD-dependent epimerase/dehydratase family protein	A0A2K9L0I7	Tupanvirus	7.2e-86	51.4

DBSCAN-SWA_2

1175723 : 1181451

Enterobacteria_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG73683.1\|1175723_1176740_+	dTDP-glucose 4,6-dehydratase	A0A1D7XFE8	Escherichia_phage	4.0e-79	46.8
AXG73684.1\|1176741_1177602_+	glucose-1-phosphate thymidylyltransferase	H9NC64	Sphingomonas_phage	1.8e-96	60.8
AXG73685.1\|1177610_1178162_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	4.0e-41	51.5
AXG73686.1\|1178155_1178995_+	dTDP-4-dehydrorhamnose reductase	I7HXC9	Enterobacteria_phage	1.3e-38	37.2
AXG73687.1\|1178987_1179947_+	glycosyltransferase	S5FKN0	Shigella_phage	2.2e-47	34.4
AXG73688.1\|1179969_1181451_-	hypothetical protein	O21944	Shigella_phage	1.5e-26	29.0

DBSCAN-SWA_3

1529140 : 1534702

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG73990.1\|1529140_1529527_-	septal ring lytic transglycosylase RlpA family protein	F5B3X9	Synechococcus_phage	1.6e-17	60.0
AXG73991.1\|1529533_1529941_-	septal ring lytic transglycosylase RlpA family protein	A0A0R6PH45	Moraxella_phage	1.4e-14	50.6
AXG73992.1\|1530009_1530450_-	hypothetical protein	NA	NA	NA	NA
AXG73993.1\|1530632_1531727_+	DNA polymerase IV	A0A290GHP0	Caldibacillus_phage	4.0e-08	26.4
AXG73994.1\|1531779_1532547_-	hypothetical protein	NA	NA	NA	NA
AXG73995.1\|1532681_1533161_-	ribonuclease HI	A0A223LIW7	Erwinia_phage	5.2e-21	40.7
AXG73996.1\|1533162_1533684_-	hypothetical protein	NA	NA	NA	NA
AXG73997.1\|1533716_1534289_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.6e-16	29.6
AXG73998.1\|1534465_1534702_+	acyl carrier protein	B2ZXV3	Ralstonia_phage	1.8e-06	38.1

DBSCAN-SWA_4

1978474 : 2042969

Agrobacterium_phage(16.67%)

tail,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXG74340.1\|1978474_1979392_-\|tRNA	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	NA	NA	NA	NA
AXG74341.1\|1979394_1980204_-	ion transporter	NA	NA	NA	NA
AXG74342.1\|1980230_1981595_-	exonuclease	NA	NA	NA	NA
AXG74343.1\|1981739_1982402_-	YggS family pyridoxal phosphate-dependent enzyme	NA	NA	NA	NA
AXG74344.1\|1982426_1983641_-	DUF1015 domain-containing protein	NA	NA	NA	NA
AXG74345.1\|1983736_1984621_-	3-hydroxybutyryl-CoA dehydrogenase	NA	NA	NA	NA
AXG74346.1\|1984673_1985639_-	gfo/Idh/MocA family oxidoreductase	NA	NA	NA	NA
AXG74347.1\|1985807_1986449_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	1.1e-31	47.3
AXG75268.1\|1986452_1986845_-	bacillithiol system redox-active protein YtxJ	NA	NA	NA	NA
AXG74348.1\|1986973_1989577_+	ATP-dependent chaperone ClpB	A0A223W0B1	Agrobacterium_phage	1.1e-120	33.4
AXG74349.1\|1989712_1990564_+	aldose 1-epimerase family protein	NA	NA	NA	NA
AXG74350.1\|1990586_1990811_-	DUF2132 domain-containing protein	NA	NA	NA	NA
AXG74351.1\|1990910_1991363_+	SsrA-binding protein SmpB	W5RAM5	Staphylococcus_phage	1.5e-22	43.3
AXG74352.1\|1991424_1992711_-	fumarylacetoacetase	NA	NA	NA	NA
AXG74353.1\|1992820_1994095_+	serine hydroxymethyltransferase	A0A240F2Y9	Aeromonas_phage	1.3e-90	48.2
AXG74354.1\|1994148_1994754_+	Crp/Fnr family transcriptional regulator	NA	NA	NA	NA
AXG74355.1\|1994811_1995273_+	hypothetical protein	NA	NA	NA	NA
AXG74356.1\|1995332_1996451_+	hypothetical protein	NA	NA	NA	NA
AXG74357.1\|1996528_1997995_+	magnesium chelatase	NA	NA	NA	NA
AXG74358.1\|1998122_1999361_+	sodium:proton antiporter	A0A2H4J178	uncultured_Caudovirales_phage	3.1e-41	40.2
AXG74359.1\|1999504_2000077_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
AXG74360.1\|2000209_2000755_+	RNA polymerase sigma factor	NA	NA	NA	NA
AXG74361.1\|2000775_2001057_+	hypothetical protein	NA	NA	NA	NA
AXG74362.1\|2001067_2001538_+	hypothetical protein	NA	NA	NA	NA
AXG74363.1\|2001530_2002229_+	hypothetical protein	NA	NA	NA	NA
AXG74364.1\|2002225_2003248_+	cytochrome-c peroxidase	NA	NA	NA	NA
AXG74365.1\|2003315_2004659_+	YHYH protein	M1TUM2	Synechococcus_phage	1.7e-32	38.7
AXG74366.1\|2004788_2005226_+	hypothetical protein	NA	NA	NA	NA
AXG75269.1\|2005572_2007009_+	sodium:solute symporter family protein	A0A240F3J2	Aeromonas_phage	1.5e-07	22.8
AXG74367.1\|2007289_2008183_+	J domain-containing protein	A0A2L0UZR4	Agrobacterium_phage	1.9e-21	30.6
AXG74368.1\|2008192_2008483_+	MerR family transcriptional regulator	NA	NA	NA	NA
AXG74369.1\|2008491_2009799_-	DUF4157 domain-containing protein	NA	NA	NA	NA
AXG74370.1\|2009816_2010416_-	hypothetical protein	NA	NA	NA	NA
AXG74371.1\|2010427_2011792_-	ATP-binding protein	A0A1C9EGA6	Acidianus_two-tailed_virus	1.4e-10	36.1
AXG74372.1\|2011795_2012698_-	hypothetical protein	NA	NA	NA	NA
AXG74373.1\|2012772_2013618_-	hypothetical protein	NA	NA	NA	NA
AXG74374.1\|2013639_2015655_-	hypothetical protein	NA	NA	NA	NA
AXG74375.1\|2015716_2019952_-	hypothetical protein	NA	NA	NA	NA
AXG74376.1\|2019923_2022332_-	hypothetical protein	NA	NA	NA	NA
AXG74377.1\|2022328_2025982_-	hypothetical protein	NA	NA	NA	NA
AXG74378.1\|2025992_2026418_-\|tail	phage tail protein	NA	NA	NA	NA
AXG74379.1\|2026410_2026710_-	type VI secretion protein	NA	NA	NA	NA
AXG74380.1\|2026722_2028519_-	type VI secretion system tip protein VgrG	NA	NA	NA	NA
AXG74381.1\|2028518_2029196_-	hypothetical protein	NA	NA	NA	NA
AXG74382.1\|2029383_2029854_-\|tail	phage tail protein	NA	NA	NA	NA
AXG74383.1\|2029837_2030311_-\|tail	phage tail protein	T2KSM5	uncultured_phage	1.3e-21	44.2
AXG74384.1\|2030369_2031950_-\|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	1.0e-20	25.6
AXG74385.1\|2031976_2032792_-	hypothetical protein	NA	NA	NA	NA
AXG74386.1\|2032788_2033358_-	DUF4255 domain-containing protein	NA	NA	NA	NA
AXG74387.1\|2033581_2034439_-	hypothetical protein	NA	NA	NA	NA
AXG74388.1\|2034683_2035361_-	DNA-binding response regulator	NA	NA	NA	NA
AXG74389.1\|2035357_2036161_-	sensor histidine kinase	NA	NA	NA	NA
AXG74390.1\|2036115_2036766_-	hypothetical protein	NA	NA	NA	NA
AXG74391.1\|2036786_2037146_-	hypothetical protein	NA	NA	NA	NA
AXG74392.1\|2037425_2041190_+	hypothetical protein	NA	NA	NA	NA
AXG74393.1\|2041735_2042323_+\|tail	phage tail protein	NA	NA	NA	NA
AXG74394.1\|2042381_2042969_+\|tail	phage tail protein	E3T4R8	Cafeteria_roenbergensis_virus	3.2e-12	30.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage