CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP022898	Staphylococcus aureus strain 422 chromosome, complete genome	9 crisprs	cas3,DEDDh,DinG,csa3,WYL	3	4	8	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP022898_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022898_1

481005-481094

Unclear

Consensus_repeat	Method
AGTTGGGGTGTGGGCCCCAACACAGAAGCTG	CRISPRCasFinder

1 spacers

cas3

The CRISPR arrays of CP022898_1

>merge|CP022898|1|481005-481094|CRISPRCasFinder
AGTTGGGGTGTGGGCCCCAACACAGAAGCTGACGAAAAGTCAGCTTACGATAAAGTGCAAGTTGGGGTGTGGGCCCCAACATAGAAGCTG

>CP022898|1|1|481005-481094|CRISPRCasFinder
AGTTGGGGTGTGGGCCCCAACACAGAAGCTG	ACGAAAAGTCAGCTTACGATAAAGTGCA
AGTTGGGGTGTGGGCCCCAACATAGAAGCTG

Protein	Signature genes	Signature genes Name	Protein_function
CP022898.1\|AXJ47785.1\|482487_483420_+\|Cysteine-synthase	unknown	unknown	gnl\|CDD\|273465
CP022898.1\|AXJ47777.1\|474042_475236_+\|Nucleoside-triphosphate-pyrophosphohydrolase/pyrophosphatase-MazG	unknown	unknown	gnl\|CDD\|226465
CP022898.1\|AXJ47792.1\|502207_502768_+\|Glutamine-amidotransferase-subunit-PdxT	unknown	unknown	gnl\|CDD\|237411
CP022898.1\|AXJ47793.1\|502975_504190_-\|Nucleoside-permease-NupC	unknown	unknown	gnl\|CDD\|224883
CP022898.1\|AXJ47786.1\|483635_484439_+\|Dihydropteroate-synthase	unknown	unknown	gnl\|CDD\|238380
CP022898.1\|AXJ47787.1\|484416_484782_+\|Dihydroneopterin-aldolase	unknown	unknown	gnl\|CDD\|238298
CP022898.1\|AXJ47778.1\|475232_475496_+\|Heat-shock-protein-15	unknown	unknown	gnl\|CDD\|224109
CP022898.1\|AXJ47788.1\|484778_485255_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-pyrophosphokinase	unknown	unknown	gnl\|CDD\|223872
CP022898.1\|AXJ47789.1\|485793_487281_+\|Lysine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234778
CP022898.1\|AXJ47791.1\|501316_502204_+\|Pyridoxal-biosynthesis-lyase-PdxS	unknown	unknown	gnl\|CDD\|179769
CP022898.1\|AXJ47779.1\|475513_475906_+\|Cell-division-protein-DivIC	unknown	unknown	gnl\|CDD\|225471
CP022898.1\|AXJ47775.1\|469020_472527_+\|Transcription-repair-coupling-factor	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224118
CP022898.1\|AXJ47776.1\|472516_474043_+\|putative-cell-division-protein-YtgP	unknown	unknown	gnl\|CDD\|240529
CP022898.1\|AXJ47782.1\|477891_478431_+\|Hypoxanthine-guanine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|223707
CP022898.1\|AXJ47783.1\|478688_480782_+\|ATP-dependent-zinc-metalloprotease-FtsH	unknown	unknown	gnl\|CDD\|273520
CP022898.1\|AXJ47774.1\|468448_469021_+\|Peptidyl-tRNA-hydrolase	unknown	unknown	gnl\|CDD\|223271
CP022898.1\|AXJ47781.1\|476591_477887_+\|tRNA(Ile)-lysidine-synthase	unknown	unknown	gnl\|CDD\|366502
CP022898.1\|AXJ47784.1\|481427_482309_+\|33-kDa-chaperonin	unknown	unknown	gnl\|CDD\|234643
CP022898.1\|AXJ47780.1\|476010_476412_+\|General-stress-protein-13	unknown	unknown	gnl\|CDD\|236305
CP022898.1\|AXJ47790.1\|499830_501213_-\|HTH-type-transcriptional-regulatory-protein-GabR	unknown	unknown	gnl\|CDD\|224089

Protein	Function_ID	Function_description	E-value
CP022898.1\|AXJ47785.1\|482487_483420_+\|Cysteine-synthase	gnl\|CDD\|273465	TIGR01139, Cysteine_synthase, cysteine synthase A. This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family].	3.8342e-167
CP022898.1\|AXJ47777.1\|474042_475236_+\|Nucleoside-triphosphate-pyrophosphohydrolase/pyrophosphatase-MazG	gnl\|CDD\|226465	COG3956, COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only].	0
CP022898.1\|AXJ47792.1\|502207_502768_+\|Glutamine-amidotransferase-subunit-PdxT	gnl\|CDD\|237411	PRK13525, PRK13525, pyridoxal 5'-phosphate synthase glutaminase subunit PdxT.	9.71225e-112
CP022898.1\|AXJ47793.1\|502975_504190_-\|Nucleoside-permease-NupC	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	1.07791e-164
CP022898.1\|AXJ47786.1\|483635_484439_+\|Dihydropteroate-synthase	gnl\|CDD\|238380	cd00739, DHPS, DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and protein biosynthesis. Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS. Sulfonamide drugs, which are substrate analogs of pABA, target DHPS.	1.16187e-122
CP022898.1\|AXJ47787.1\|484416_484782_+\|Dihydroneopterin-aldolase	gnl\|CDD\|238298	cd00534, DHNA_DHNTPE, Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is DHNA which catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. Though it is known that DHNTPE catalyzes the epimerization of dihydroneopterin triphosphate to dihydromonapterin triphosphate, the biological role of this enzyme is still unclear. It is hypothesized that it is not an essential protein since a folX knockout in E. coli has a normal phenotype and the fact that folX is not present in H. influenza. In addition both enzymes have been shown to be able to compensate for the other's activity albeit at slower reaction rates. The functional enzyme for both is an octamer of identical subunits. Mammals lack many of the enzymes in the folate pathway including, DHNA and DHNTPE.	1.74147e-48
CP022898.1\|AXJ47778.1\|475232_475496_+\|Heat-shock-protein-15	gnl\|CDD\|224109	COG1188, COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis].	2.63429e-32
CP022898.1\|AXJ47788.1\|484778_485255_+\|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-pyrophosphokinase	gnl\|CDD\|223872	COG0801, FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].	9.12434e-73
CP022898.1\|AXJ47789.1\|485793_487281_+\|Lysine--tRNA-ligase	gnl\|CDD\|234778	PRK00484, lysS, lysyl-tRNA synthetase; Reviewed.	0
CP022898.1\|AXJ47791.1\|501316_502204_+\|Pyridoxal-biosynthesis-lyase-PdxS	gnl\|CDD\|179769	PRK04180, PRK04180, pyridoxal 5'-phosphate synthase lyase subunit PdxS.	0
CP022898.1\|AXJ47779.1\|475513_475906_+\|Cell-division-protein-DivIC	gnl\|CDD\|225471	COG2919, COG2919, Septum formation initiator [Cell division and chromosome partitioning].	3.2193e-21
CP022898.1\|AXJ47775.1\|469020_472527_+\|Transcription-repair-coupling-factor	gnl\|CDD\|224118	COG1197, Mfd, Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription].	0
CP022898.1\|AXJ47776.1\|472516_474043_+\|putative-cell-division-protein-YtgP	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	2.05199e-87
CP022898.1\|AXJ47782.1\|477891_478431_+\|Hypoxanthine-guanine-phosphoribosyltransferase	gnl\|CDD\|223707	COG0634, Hpt, Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism].	4.50006e-94
CP022898.1\|AXJ47783.1\|478688_480782_+\|ATP-dependent-zinc-metalloprotease-FtsH	gnl\|CDD\|273520	TIGR01241, ATP-dependent_zinc_metalloprotease_FtsH, ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides].	0
CP022898.1\|AXJ47774.1\|468448_469021_+\|Peptidyl-tRNA-hydrolase	gnl\|CDD\|223271	COG0193, Pth, Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis].	5.81135e-97
CP022898.1\|AXJ47781.1\|476591_477887_+\|tRNA(Ile)-lysidine-synthase	gnl\|CDD\|366502	pfam01171, ATP_bind_3, PP-loop family. This family of proteins belongs to the PP-loop superfamily.	3.71037e-77
CP022898.1\|AXJ47784.1\|481427_482309_+\|33-kDa-chaperonin	gnl\|CDD\|234643	PRK00114, hslO, Hsp33 family molecular chaperone HslO.	1.29884e-159
CP022898.1\|AXJ47780.1\|476010_476412_+\|General-stress-protein-13	gnl\|CDD\|236305	PRK08582, PRK08582, RNA-binding protein S1.	4.42227e-78
CP022898.1\|AXJ47790.1\|499830_501213_-\|HTH-type-transcriptional-regulatory-protein-GabR	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	2.73424e-131

>CP022898.1|AXJ47783.1|478688_480782_+|ATP-dependent-zinc-metalloprotease-FtsH
MQKAFRNVLVIVIIGVIIFGLFSYLNGNGNMPKQLTYNQFTEKLEKGDLKTLEIQPQQNVYMVSGKTKNDEDYSSTILYNNEKELQKITDAAKKQNGVKLTIKEEEKQSVFVSILSTLIPVVVIALLFIFFLSQAQGGGSGGRMMNFGKSKAKMYDNNKRRVRFSDVAGADEEKQELIEIVDFLKDNKKFKEMGSRIPKGVLLVGPPGTGKTLLARAVAGEAGAPFFSISGSDFVEMFVGVGASRVRDLFDNAKKNAPCIIFIDEIDAVGRQRGAGVGGGHDEREQTLNQLLVEMDGFGENEGIIMIAATNRPDILDPALLRPGRFDRQIQVGRPDVKGREAILHVHAKNKPLDETVDLKAISQRTPGFSGADLENLLNEASLIAVREGKKKIDMRDIEEATDRVIAGPAKKSRVISKKERNIVAHHEAGHTIIGMVLDEAEVVHKVTIVPRGQAGGYAMMLPKQDRFLMTEQELLDKICGLLGGRVSEDINFNEVSTGASNDFERATQIARSMVTQYGMSKKLGPLQFGHSNGQVFLGKDMQGEPNYSSQIAYEIDKEVQRIVKEQYERCKQILLEHKEQLILIAETLLTEETLVAEQIQSLFYEGKLPEIDYDAAKVVKDEDSEFNDGKFGKSYEEIRKEQLEDGQRDESEDRKEEKDIAEDKKEADKSDEKDEPAHRQAPNIEKPYDPNHPDNK
>CP022898.1|AXJ47782.1|477891_478431_+|Hypoxanthine-guanine-phosphoribosyltransferase
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYRELYRNLPYIGTLKPEVYSN
>CP022898.1|AXJ47781.1|476591_477887_+|tRNA(Ile)-lysidine-synthase
MQLNSNGWHVDDHIVVSVSTGIDSMCLLYQLLKDYKDSYRKLTCLHVNHGVRSASIEEARFLEAYCERHHIDLHIKKLDLSHSLNRNNSIQNEARIKRYEWFDEMMNVLEADVLLTAHHLDDQLETIMYRIFNGKSTRNKLGFDELSKRKGYQIYRPLLAVSKKEIKQFQERYHIPYFEDESNKDNKYVRNDIRNRIIPAIDENNQLKVSHLLKLKQWHDEQYDILQYSAKQFIQEFVKFDEQSKYLEVSRQSFNDLPNSLKMVVLDCLLSKYYELFNISAKTYEEWFKQFSSKKAQFSINLTDKWIIQIAYGKLIIMAKNNGDTYFRVQTIEKPGNYIFNKYRLEIHSNLPKCLFPLSVRTRQSGDTFKLNGRDGYKKVNRLFIDCKVQQWVRDQMPIVLDKQQRIIAVGDLYQQQTIKQWIIISKNGDE
>CP022898.1|AXJ47780.1|476010_476412_+|General-stress-protein-13
MSIEVGNKLKGKVTGIKKFGAFVELPEGKSGLVHISEVADNYVENVEEHLSVGDEVDVKVLSIADDGKISLSIKKAKDRPRRQHTSKPSHQKPVQKAEDFEKKLSNFLKDSEDKLTSIKRQTESRRGGKGSRR
>CP022898.1|AXJ47779.1|475513_475906_+|Cell-division-protein-DivIC
MKNKVEHIENQYTSQENKKKQRQKMKMRVVRRRITVFAGVLLAIIVVLSILLVVQKHRNDIDAQERKAKEAQFQKQQNEEIALKEKLNNLNDKDYIEKIARDDYYLSNKGEVIFRLPEDKDSSSSKSSKK
>CP022898.1|AXJ47778.1|475232_475496_+|Heat-shock-protein-15
MRLDKYLKVSRLIKRRTLAKEVSDQGRITINGNVAKAGSDVKVEDVLTIRFGQKLVTVKVTALNEHASKDNAKGMYEIIEERRLEEA
>CP022898.1|AXJ47777.1|474042_475236_+|Nucleoside-triphosphate-pyrophosphohydrolase/pyrophosphatase-MazG
MAHTITIVGLGNYGIDDLPLGIYKFLKTQNKVYARTLDHPVIESLQDELTFQSFDHVYETHDQFEDVYNDIVAQLVEAANEKDIVYAVPGHPRVAETTTVKLLALAKDNTDIDVKVLGGKSFIDDVFEAVNVDPNDGFTLLDATSLQEVTLNVRTHTLITQVYSAMVAANLKITLMERYPDDYPVQIVTGARSDGADNVVTCPLYELDHDENAFNNLTSVFVPKITTPTYLYHDFDFATEVIDTLVDEDKGCPWDKVQTHETLKRYLLEETFELFEAIDNEDDWHMIEELGDILLQVLLHTSIGKKEGYIDIKEVITSLNAKMIRRHPHIFGDANAETIDDLKEIWSKAKDAEGKQPRVKFEKVFAEHFLNLYEKTKDKSFDEAALKQWLEKGESNT
>CP022898.1|AXJ47776.1|472516_474043_+|putative-cell-division-protein-YtgP
MKHKEAFNGVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGEYHSDEAYAKAVAYIQLVGILLFIAIFVFANNIAYMMGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIVTIVIFVDRGWTIYEAGTIAILASTIGFLGSSIYLVAHRPFKFKMVNNTAKIVWKQFALSVLIFAISQLIVILWQVIDSVTIIKSLQAIRVPFDVAITEKGVYDRGASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKITILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMMAGLVIKFILNIILIRLSGIIGASISTVVSLIIFGTIIHIAVTRKYHLHAMRRFFINVVLGMVFMSIVVQCVLNIVTTHGRITGLIELLCAAVLGIIALFFYIFRFNVLTYKELTYLPFGSKLYQIKKGRR
>CP022898.1|AXJ47775.1|469020_472527_+|Transcription-repair-coupling-factor
MTILTTLIKEDNHFQDLNQVFGQANTLVTGLSPSAKVTMIAEKYAQSNQQLLLITNNLYQADKLETDLLQFVDAEELYKYPVQDIMTEEFSTQSPQLMSERIRTLTALAQGKKGLFIVPLNGLKKWLTPVEMWQNHQMTLRVGEDIDVDQFLNKLVNMGYKRESVVSHIGEFSLRGGIIDIFPLIGEPIRIELFDTEIDSIRGFDVETQRSKDNIEEVDITTASDYIITEEVISHLKEELKTAYENTRPKIDKSVRNDLKETYESFKLFESTYFDHQILRRLVAFMYETPSTIIDYFQKDAIIAVDEFNRIKETEESLTVESDTFISNIIESGNGFIGQSFIKYDDFETLIEGYPVTYFSLFATTMPIKLNHIIKFSCKPVQQFYGQYDIMRSEFQRYVNQNYHIVVLVETETKVERMQAMLSEMHIPSITKLHRSMSSGQAVIIEGSLSEGFELPDMGLVVITERELFKSKQKKQRKRTKAISNAEKIKSYQDLNVGDYIVHVHHGVGRYLGVETLEVGQTHRDYIKLQYKGTDQLFVPVDQMDQVQKYVASEDKTPKLNKLGGSEWKKTKAKVQQSVEDIAEELIDLYKEREMAEGYQYGEDTAEQTTFELDFPYELTPDQAKSIDEIKDDMQKSRPMDRLLCGDVGYGKTEVAVRAAFKAVMEGKQVAFLVPTTILAQQHYETLIERMQDFPVEIQLMSRFRTPKEIKQTKEGLKTGFVDIVVGTHKLLSKDIQYKDLGLLIVDEEQRFGVRHKERIKTLKHNVDVLTLTATPIPRTLHMSMLGVRDLSVIETPPENRFPVQTYVLEQNMSFIKEALERELSRDGQVFYLYNKVQSIYEKREQLQMLMPDANIAVAHGQMTERDLEETMLSFINNEYDILVTTTIIETGVDVPNANTLIIEDADRFGLSQLYQLRGRVGRSSRIGYAYFLHPANKVLTETAEDRLQAIKEFTELGSGFKIAMRDLNIRGAGNLLGKQQHGFIDTVGFDLYSQMLEEAVNEKRGIKEPESEVPEVEVDLNLDAYLPTEYIANEQAKIEIYKKLRKTETFDQIIDIKDELIDRFNDYPVEVARLLDIVEIKVHALHSGITLIKDKGKIIDIHLSVKATENIDGEVLFKATQPLGRTMKVGVQNNAMTITLTKQNQWLDSLKFLVKCIEESMRISDEA
>CP022898.1|AXJ47774.1|468448_469021_+|Peptidyl-tRNA-hydrolase
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDHVMNEFNGEVK
>CP022898.1|AXJ47784.1|481427_482309_+|33-kDa-chaperonin
MTHDYIVKALAFDGEIRAYAALTTETVQEAQTRHYTWPTASAAMGRTMTATAMMGAMLKGDQKLTVTVDGQGPIGRIIADANAKGEVRAYVDHPQTHFPLNEQGKLDVRRAVGTNGSIMVVKDVGMKDYFSGASPIVSGELGEDFTYYYATSEQTPSSVGLGVLVNPDNTIKAAGGFIIQVMPGAKDETISKLEKAISEMTPVSKLIEQGLTPEGLLNEILGKDHVQILEKMPVQFECNCSHEKFLNAIKGLGEAEIQNMIKEDHGAEAVCHFCGNKYKYTEEELNVLLESLV
>CP022898.1|AXJ47785.1|482487_483420_+|Cysteine-synthase
MAQKPVDNITQIIGGTPVVKLRNVVDDNAADVYVKLDYQNPGGSVKDRIALAMIEKAEREGKIKPGDTIVEPTSGNTGIGLAFVCAAKGYKAVFTMPETMSQERRNLLKAYGAELVLTPGSEAMKGAIKKAKELKEEHGYFEPQQFENPANPEVHELTTGPELLQQFEGKTIDAFLAGVGTGGTLSGVGKVLKKEYPNIEVVAIEPEASPVLSGGEPGPHKLQGLGAGFIPGTLNTEIYDSIIKVGNDTAMEMSRRVAKEEGILAGISSGAAIYAAIQKAKELGKGKTVVTVLPSNGERYLSTPLYSFDD
>CP022898.1|AXJ47786.1|483635_484439_+|Dihydropteroate-synthase
MTKTKIMGILNVTPDSFSDGGKFNNVESAVTRVKAMMDEGADIIDVGGASTRPGHEMISLEEELNRVLPVVEAIVGFDVKISVDTFRSEVAEACLKLGVDIINDQWAGLYDHRMFQVVAKYDAEIVLMHNGNGNRDEPVVEEMLTSLLAQAHQAKIAGISSNKIWLDPGIGFAKTRNEEAEVMARLDELVATEYPVLLATSRKRFTKEMMGYDTTPVERDEVTAATTAYGIMKGVRAVRVHNVELNAKLAKGIDFLKENENARHNLS
>CP022898.1|AXJ47787.1|484416_484782_+|Dihydroneopterin-aldolase
MQDTIFLKGMRFYGYHGALSAENEIGQIFKVDVTLKVDLAEAGRTDNVIDTVHYGEVFEEVKSIMEGKAVNLLEHLAERIANRINSQYNRVMETKVRITKENPPIPGHYDGVGIEIVRENK
>CP022898.1|AXJ47788.1|484778_485255_+|2-amino-4-hydroxy-6--hydroxymethyldihydropteridine-pyrophosphokinase
MIQAYLGLGSNIGDRESQLNDAIKILNEYDGINVFNISPIYETAPVGYTEQPNFLNLCVEIQTTLTVLQLLECCLKTEECLHRVRKERWGPRTLDVDILLYGEEMIDLPKLSVPHPRMNERAFVLIPLNDIAANVIEPRSKLKVKDLVFVDDSVKRYK
>CP022898.1|AXJ47789.1|485793_487281_+|Lysine--tRNA-ligase
MSEEMNDQMLVRRQKLQELYDLGIDPFGSKFDRSGLSSDLKEEWDQYSKEELVEKEADSHVAIAGRLMTKRGKGKAGFAHVQDLAGQIQIYVRKDQVGDDEFDLWKNADLGDIVGVEGVMFKTNTGELSVKAKKFTLLTKSLRPLPDKFHGLQDIEQRYRQRYLDLITNEDSTRTFINRSKIIQEMRNYLNNKGFLEVETPMMHQIAGGAAARPFVTHHNALDATLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIELYEAYADYHDIMDLTESMVRHIANEVLGSAKVQYNGETIDLESAWTRLHIVDAVKEATGVDFYEIKSDEEAKALAKEHGIEIKDTMKYGHILNEFFEQKVEETLIQPTFIYGHPTEISPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQKGRFEAQLVEKAQGNDEAHEMDEDYIEALEYGMPPTGGLGIGIDRLVMLLTDSPSIRDVLLFPYMRQK
>CP022898.1|AXJ47790.1|499830_501213_-|HTH-type-transcriptional-regulatory-protein-GabR
MKNTLYHQLYEKLKKQIIEGQFKEGDKFYSKRQLSKHLSISQTTVEHAYQLLLDEGYIYSRPRSGYFVSEIESLTILNNQPIPSLFDDDSYKPKASDEAYDYAFNLDEIDTKHFPIELFRKYSKDLYDTNHLNQLRRGHFQGELHLRFQLAFYLFTNRGVICDPNQIIIGSSTEQLVNQLVDLLYTSTFIIEKPSYPPIKNILDKKQVEYEQIEVEDNGINVDEVIKSQKNIVYITPSHQFPTGYVMDLKKRTQLIQWAQEKEERFIIEDDYDSEFRYFGKPIPAIQGLYSRGEKVIYISTFSKSIFPSCRVAYMVLPYSIMKKYHSQNHIEGNTVPVHMQNLIATFISSGGFERHLNKMRRIYRRKLTYILNRLKPYKEQLDIQGAETGMHFTITVKNGLTLQECLDRANKVKLKLQVYNFDDDQDYKKTPKFILGFGGIDDDALKPHVDALIKSLIIK
>CP022898.1|AXJ47791.1|501316_502204_+|Pyridoxal-biosynthesis-lyase-PdxS
MSKIIGSDRVKRGMAEMQKGGVIMDVVNAEQARIAEEAGAVAVMALERVPSDIRAAGGVARMANPKIVEEVMNAVSIPVMAKARIGHITEARVLEAMGVDYIDESEVLTPADEEYHLRKDQFTVPFVCGCRNLGEAARRIGEGAAMLRTKGEPGTGNIVEAVRHMRQVNSEVSRLTVMNDDEIMTFAKDIGAPYEILKQIKDNGRLPVVNFAAGGVATPQDAALMMELGADGVFVGSGIFKSEDPEKFAKAIVQATTHYQDYELIGRLASELGTAMKGLDINQLSLEERMQERGW
>CP022898.1|AXJ47792.1|502207_502768_+|Glutamine-amidotransferase-subunit-PdxT
MKIGVLALQGAVREHIRHIELSGHEGIAVKKVEQLEEIEGLILPGGESTTLRRLMNLYGFKEALQNSTLPMFGTCAGLIVLAQDIVGEEGYLNKLNITVQRNSFGRQVDSFETELDIKGIATDIEGVFIRAPHIEKVGQGVDILCKVNEKIVAVQQGKYLGVSFHPELTDDYRVTDYFINHIVKKA
>CP022898.1|AXJ47793.1|502975_504190_-|Nucleoside-permease-NupC
MHILIGIIGIIFFLALAFLFSSDRKNIRWKYVGILLAIQLIFAFILLKTTMGIKVIGGISNGFNYLLLKAADGVNFVFGGIQYIDPKQPPFFFSVLLPIVFISAIIGILQYTKILPLIINVLGFLISKINGMGRLESYNAVAAAILGQSEVFISIKKQLPYIPKQRLYTLTASAMSTVSASIIGAYFTLIEPKYVVTAVVLNLFGGFIIASIINPYKVNEEDDKLLVEETEERQQSFFEMLGEYILDGFKVAVIVGAMLIGYIAIIALLNGIVSNIFSTVSGGAISWDFQTLIGFVFAPFAFLVGVPWQDAVQAGSVMATKLLSNEFVAMQALGKLSDLSEHAKGVTSVFLVSFANFSSIGIISGAIKSLNDKKGDTVARFGLKLLFGATLVSFISAAIAGFFI

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Crispr_ID: CP022898_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022898_2

1041937-1042033

Orphan

Consensus_repeat	Method
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022898_2

>merge|CP022898|2|1041937-1042033|CRISPRCasFinder
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGGTAAAAGAGGGATACTTGCGCTGAGCGCATGCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG

>CP022898|2|2|1041937-1042033|CRISPRCasFinder
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG	TAAAAGAGGGATACTTGCGCTGAGCGCAT
GCATAAAAGCCCCTAACAACTAAAAGTTGTAAGG

Protein	Signature genes	Signature genes Name	Protein_function
CP022898.1\|AXJ48308.1\|1034043_1035072_+\|Phosphoribosylformylglycinamidine-cyclo-ligase	unknown	unknown	gnl\|CDD\|235439
CP022898.1\|AXJ48309.1\|1035074_1035641_+\|Phosphoribosylglycinamide-formyltransferase	unknown	unknown	gnl\|CDD\|223376
CP022898.1\|AXJ48319.1\|1046003_1046270_+\|Phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
CP022898.1\|AXJ48306.1\|1030397_1032587_+\|Phosphoribosylformylglycinamidine-synthase-2	unknown	unknown	gnl\|CDD\|234921
CP022898.1\|AXJ48305.1\|1029733_1030405_+\|Phosphoribosylformylglycinamidine-synthase-1	unknown	unknown	gnl\|CDD\|235140
CP022898.1\|AXJ48310.1\|1035655_1037134_+\|Bifunctional-purine-biosynthesis-protein-PurH	unknown	unknown	gnl\|CDD\|234854
CP022898.1\|AXJ48324.1\|1050321_1051683_+\|Putative-cytochrome-bd-menaquinol-oxidase-subunit-I	unknown	unknown	gnl\|CDD\|376587
CP022898.1\|AXJ48322.1\|1048852_1049641_+\|Integrase-core-domain-protein	unknown	unknown	gnl\|CDD\|222853
CP022898.1\|AXJ48313.1\|1039467_1040868_-\|Putative-HMP/thiamine-import-ATP-binding-protein-YkoD	unknown	unknown	gnl\|CDD\|213192
CP022898.1\|AXJ48323.1\|1049890_1050124_-\|glutaredoxin-3	unknown	unknown	gnl\|CDD\|239274
CP022898.1\|AXJ48311.1\|1037155_1038403_+\|Phosphoribosylamine--glycine-ligase	unknown	unknown	gnl\|CDD\|237507
CP022898.1\|AXJ48307.1\|1032565_1034026_+\|Amidophosphoribosyltransferase-precursor	unknown	unknown	gnl\|CDD\|235984
CP022898.1\|AXJ48315.1\|1042042_1042177_-\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ48320.1\|1046272_1047991_+\|Phosphoenolpyruvate-protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
CP022898.1\|AXJ48312.1\|1038668_1039475_-\|Putative-HMP/thiamine-permease-protein-YkoC	unknown	unknown	gnl\|CDD\|223692
CP022898.1\|AXJ48318.1\|1045307_1045850_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368297
CP022898.1\|AXJ48314.1\|1040883_1041459_-\|Putative-HMP/thiamine-permease-protein-YkoE	unknown	unknown	gnl\|CDD\|227065
CP022898.1\|AXJ48316.1\|1042328_1043624_+\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ48321.1\|1048100_1048829_+\|Transposase	unknown	unknown	gnl\|CDD\|379233
CP022898.1\|AXJ48317.1\|1044048_1045254_+\|Ribosomal-RNA-large-subunit-methyltransferase-I	unknown	unknown	gnl\|CDD\|224017

Protein	Function_ID	Function_description	E-value
CP022898.1\|AXJ48308.1\|1034043_1035072_+\|Phosphoribosylformylglycinamidine-cyclo-ligase	gnl\|CDD\|235439	PRK05385, PRK05385, phosphoribosylaminoimidazole synthetase; Provisional.	0
CP022898.1\|AXJ48309.1\|1035074_1035641_+\|Phosphoribosylglycinamide-formyltransferase	gnl\|CDD\|223376	COG0299, PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism].	1.64347e-91
CP022898.1\|AXJ48319.1\|1046003_1046270_+\|Phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	2.44795e-51
CP022898.1\|AXJ48306.1\|1030397_1032587_+\|Phosphoribosylformylglycinamidine-synthase-2	gnl\|CDD\|234921	PRK01213, PRK01213, phosphoribosylformylglycinamidine synthase subunit PurL.	0
CP022898.1\|AXJ48305.1\|1029733_1030405_+\|Phosphoribosylformylglycinamidine-synthase-1	gnl\|CDD\|235140	PRK03619, PRK03619, phosphoribosylformylglycinamidine synthase subunit PurQ.	1.77638e-140
CP022898.1\|AXJ48310.1\|1035655_1037134_+\|Bifunctional-purine-biosynthesis-protein-PurH	gnl\|CDD\|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
CP022898.1\|AXJ48324.1\|1050321_1051683_+\|Putative-cytochrome-bd-menaquinol-oxidase-subunit-I	gnl\|CDD\|376587	pfam01654, Cyt_bd_oxida_I, Cytochrome bd terminal oxidase subunit I. This family are the alternative oxidases found in many bacteria which oxidize ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II.	1.81103e-165
CP022898.1\|AXJ48322.1\|1048852_1049641_+\|Integrase-core-domain-protein	gnl\|CDD\|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	7.81069e-47
CP022898.1\|AXJ48313.1\|1039467_1040868_-\|Putative-HMP/thiamine-import-ATP-binding-protein-YkoD	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	9.64258e-65
CP022898.1\|AXJ48311.1\|1037155_1038403_+\|Phosphoribosylamine--glycine-ligase	gnl\|CDD\|237507	PRK13790, PRK13790, phosphoribosylamine--glycine ligase; Provisional.	0
CP022898.1\|AXJ48307.1\|1032565_1034026_+\|Amidophosphoribosyltransferase-precursor	gnl\|CDD\|235984	PRK07272, PRK07272, amidophosphoribosyltransferase; Provisional.	0
CP022898.1\|AXJ48323.1\|1049890_1050124_-\|glutaredoxin-3	gnl\|CDD\|239274	cd02976, NrdH, NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase activity that is dependent on TRX reductase, not glutathione (GSH). It is part of the NrdHIEF operon, where NrdEF codes for class Ib ribonucleotide reductase (RNR-Ib), an efficient enzyme at low oxygen levels. Under these conditions when GSH is mostly conjugated to spermidine, NrdH can still function and act as a hydrogen donor for RNR-Ib. It has been suggested that the NrdHEF system may be the oldest RNR reducing system, capable of functioning in a microaerophilic environment, where GSH was not yet available. NrdH from Corynebacterium ammoniagenes can form domain-swapped dimers, although it is unknown if this happens in vivo. Domain-swapped dimerization, which results in the blocking of the TRX reductase binding site, could be a mechanism for regulating the oxidation state of the protein.	1.21197e-16
CP022898.1\|AXJ48320.1\|1046272_1047991_+\|Phosphoenolpyruvate-protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
CP022898.1\|AXJ48312.1\|1038668_1039475_-\|Putative-HMP/thiamine-permease-protein-YkoC	gnl\|CDD\|223692	COG0619, CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].	1.09792e-29
CP022898.1\|AXJ48318.1\|1045307_1045850_+\|hypothetical-protein	gnl\|CDD\|368297	pfam05128, DUF697, Domain of unknown function (DUF697). Family of bacterial hypothetical proteins that is sometimes associated with GTPase domains.	0.00760449
CP022898.1\|AXJ48314.1\|1040883_1041459_-\|Putative-HMP/thiamine-permease-protein-YkoE	gnl\|CDD\|227065	COG4721, COG4721, ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism].	4.34592e-70
CP022898.1\|AXJ48321.1\|1048100_1048829_+\|Transposase	gnl\|CDD\|379233	pfam13518, HTH_28, Helix-turn-helix domain. This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.	2.91873e-13
CP022898.1\|AXJ48317.1\|1044048_1045254_+\|Ribosomal-RNA-large-subunit-methyltransferase-I	gnl\|CDD\|224017	COG1092, COG1092, Predicted SAM-dependent methyltransferases [General function prediction only].	5.99133e-145

>CP022898.1|AXJ48314.1|1040883_1041459_-|Putative-HMP/thiamine-permease-protein-YkoE
MSKGLKLSEILVTVLISVVFAVIYNLWWFVYNGVQATGLHLEQLTNGVWFMAAIVCYLIIPKPGIALLAEFAAGAGETIIMGRFDIPTIVYAFIQGLACELVFAIFKYQSRSVMVAMLAGFCTAIAAFPIDYFYGYLNEVAGWNLTLFIVFRLISGAVVAGVLSYLLVKALDKTGVTKLFRPAAKEDYDNL
>CP022898.1|AXJ48313.1|1039467_1040868_-|Putative-HMP/thiamine-import-ATP-binding-protein-YkoD
MLKVSDLRLKYPSGQRKIFDHLNITIQDKEKVLLLGPSGCGKSTLLNVLSGIVPNLIELPMKYDELIVDPLSGVIFQDPDSQFCMPKVYEELAFVLENRQVPREDMDALIINALNMVNLNVTPETYIKDLSGGMKQKLAIVETILQQSKTLFLDEPTAMLDVQATEDLWTKLIELWENQTVVIVEHKVKHIWNHVDRVILMDYNGNIIADECPEIILQKYVHLLSEYGVWHPRAWEFAPSRVDFPTANSHLLQFKNGRIIRGKSTLLSFSDLEIGLGEWITITGANGSGKTTLLESIMQLIKYQGDVYFENQRLTKIKHAAKHMYLVYQNPELQFITNSVYDEINIHFNHLSKDQSDDETMQLLKLLDLENVKDQHPYELSIGQKRRLSVATALSSKADIIFLDEPTFGLDSHNTFQLIKLFQKRINLGQSIVMVTHDDEIIERYPSRRLKISDGALLDCDGDTNV
>CP022898.1|AXJ48312.1|1038668_1039475_-|Putative-HMP/thiamine-permease-protein-YkoC
MYEQWKVRQSFVDDVNIITKLFLGIILFFFIIFVHNFDFMLYITILMLVFLLMFNGTQFKITAIFITISIGFALLSSLFMILYGNGSHTILKFGFIHITTESLVRGLHVSLRTIAISFFGILIALTSQVVMIFYSLMQHLKVKSKVAYAFMAAIRMIPLMISSLIQLRRSLKMRYQMIDASNYRGLKRFKHLIIPLLSQNIRKAHQLSVAMESKGFRDGPRTYYYNVPFSYKDVIFIIVLIAIITLAYYCSINLPITGIDDVRLGRVG
>CP022898.1|AXJ48311.1|1037155_1038403_+|Phosphoribosylamine--glycine-ligase
MNVLVIGAGGREHALAYKLNQSNLVKQVFVIPGNEAMTPIAEVHTEISESDHQGILDFAKQQDVDWVVIGPEQPLIDGLADILRANGFKVFGPNKQAAQIEGSKLFAKKIMEKYNIPTADYKEVERKKDALTYIENCELPVVVKKDGLAAGKGVIIADTIEAARSAIEIMYGDEEEGTVVFETFLEGEEFSLMTFVNGDLAVPFDCIAQDHKRAFDHDEGPNTGGMGAYCPVPHISDDVLKLTNETIAQPIAKAMLNEGYQFFGVLYIGAILTKDGPKVIEFNARFGDPEAQVLLSRMESDLMQHIIDLDEGKRTEFKWKNESIVGVMLASKGYPDAYEKGHKVSGFDLNENYFVSGLKKQGDTFVTSGGRVILAIGKGDNVHDAQRDAYEKVSQIQSDHLFYRHDIANKALQLK
>CP022898.1|AXJ48310.1|1035655_1037134_+|Bifunctional-purine-biosynthesis-protein-PurH
MKKAILSVSNKTGIVEFAKALTQLNYELYSTGGTKRILDEANVPVRSVSDLTHFPEIMDGRVKTLHPAVHGGILADRNKPQHLNELSEQHIDLIDMVVVNLYPFQQTVANPDVTMDEAIENIDIGGPTMLRAAAKNYKHVTTIVHPADYQEVLTRLRNDSLDESYRQSLMIKVFEHTAEYDEAIVRFFKGDKETLRYGENPQQSAYFVRTSNAKHTIAGAKQLHGKQLSYNNIKDADATLALVKKFDTPAAVAVKHMNPCGVGIGDTIEQAFQHAYEADSQSIFGGIVALNRAVTPELAEQLHSIFLEVIIAPKFTDEALDILKQKKNVRLLEIDMTIDSNEEEFVSVSGGYLVQDKDNYVVPKEEMKVVTEVAPTDEQWEAMLLGWKVVPSVKSNAIILSNNKQTVGIGAGQMNRVGAAKIALERAIEINDHVALVSDGFFPMGDTVELAAQHGIKAIIQPGGSIKDQDSIDMANKHGIAMVVTGTRHFKH
>CP022898.1|AXJ48309.1|1035074_1035641_+|Phosphoribosylglycinamide-formyltransferase
MVKIAIFASGSGSNFENIVEHVESGKLENIEVTALYTDHQNAFCIDRAKKHDIPVYINEPKKFDSKAAYEQHLVTLLNEDKVEWIILAGYMRLIGPDLLASFEGKILNIHPSLLPKYKGIDAIGQAYHSGDTITGSTVHYVDSGMDTGEIIEQRQCDIRPDDSKEQLEEKVKKLEYELYPSVIAKIVK
>CP022898.1|AXJ48308.1|1034043_1035072_+|Phosphoribosylformylglycinamidine-cyclo-ligase
MSKAYEQSGVNIHAGYEAVERMSSHVKRTMRKEVIGGLGGFGATFDLSQLNMTAPVLVSGTDGVGTKLKLAIDYGKHDSIGIDAVAMCVNDILTTGAEPLYFLDYIATNKVVPEVIEQIVKGISDACVETNTALIGGETAEMGEMYHEGEYDVAGFAVGAVEKDDYVDGSEVEGGQVVIGLASSGIHSNGYSLVRKLINESGIELASNFDNRPFIDVFLEPTKLYVKPVLALKKEVSIKAMNHITGGGFYENIPRALPAGYAARIDTTSFPTPKIFDWLQQQGNIDTNEMYNIFNMGIGYTVIVDEKDVSRALKILAEQNVEAYQIGHIVKNESTAIELLGV
>CP022898.1|AXJ48307.1|1032565_1034026_+|Amidophosphoribosyltransferase-precursor
MFNYSGLNEECGVFGIWNHPEAAQLTYMGLHSLQHRGQEGAGIVVSDQNELKGERGLGLLTEAIKDDQMERLKGYQHAIGHVRYATSGNKGIENIQPFLYHFYDMSVGICHNGNLINAKSLRQNLEKQGAIFHSSSDTEVIMHLIRRSKAPTFEEALKESLRKVKGGFTFAILTKDALYGAVDPNAIRPLVVGKMKDGTYILASETCAIDVLGAEFVQDIHAGEYVVINDKGITVKSYTHHTTTAISAMEYIYFARPDSTIAGKNVHAVRKASGKKLAQESPVNADMVIGVPNSSLSAASGYAEEIGLPYEMGLVKNQYVARTFIQPTQELREQGVRVKLSAVKDIVDGKNIILVDDSIVRGTTIRRIVKMLKDSGANKVHVRIASPEFMFPSFYGIDVSTTAELISASKSPEEIKDYIGADSLAYLSVDGLIESIGLDYDAPYSGLCVESFTGDYPAGLYDYEANYKAHLSHRQKQYISKNKHFF
>CP022898.1|AXJ48306.1|1030397_1032587_+|Phosphoribosylformylglycinamidine-synthase-2
MSKFIEPSVEEIKLEKVYQDMGLSDQEYEKVCDILGRQPNFTETGIFSVMWSEHCSYKHSKPFLKQFPTSGEHVLMGPGEGAGVVDIGDNQAVVFKVESHNHPSAIEPYQGAATGVGGIIRDIVSIGARPINLLNSFRFGELDNKQNQRLLKGVVKGIGGYGNCIGIPTTAGEIEFDERYDGNPLVNAMCVGVINHDMIQKGTAKGVGNSVIYVGLKTGRDGIHGATFASEELTEESESKRPSVQIGDPFVGKKLMEATLEAITFDELVGIQDMGAAGLTSSSSEMAAKGGSGLHLRLEQVPTREPGISPYEMMLSETQERMLLVVEKGTEQKFLDLFDKHELDSAVIGEVTDTNRFVLTYDDEVYADIPVEPLADEAPVYILEGEEKNYNTSKNDYTHIDVKDTFFKLLKHPTIASKHYLYDQYDQQVGANTIIKPGLQASVVRVEGTNKAIASTIDGEARYVYNNPYEGGKMVVAEAYRNLIAVGATPLAMTDCLNYGSPEKKEIYQQLIDSTKGMAEACDILKTPVVSGNVSLYNETKGTSIFPTPVVGMVGLIENVNYLNDFEPQVGDKLYLIGDTKDDFGGSQLEKLIYGKVNHEFESLDLSSEVEKGESIKTAIREGVLSHVQTVGKGGLLITLAKLSAHYGLGLKSSIDITNAQLFSETQGRYVVSVKSGKTLNIDNAIEIGLLTDSDNFKVTTPYTEISENVSDIKQIWEGAIAQCLTTQD
>CP022898.1|AXJ48305.1|1029733_1030405_+|Phosphoribosylformylglycinamidine-synthase-1
MKFAVLVFPGSNCDRDMFNAAIKSGVEAEYVDYRETSLSGFDGVLIPGGFSFGDYLRSGAMASVAPIISEVKRLAAEGKPVLGVCNGFQILTEIGLLPGALLHNDSHLFISRNEELEIVNNQTAFTNLYEQGEKVIYPVAHGEGHYYCTDEIYQQLKANNQIILKYVNNPNGSYDDIAGIVNEKGNVCGMMPHPERALETLLGTDSGVKLFEAMVKSWREQHV
>CP022898.1|AXJ48315.1|1042042_1042177_-|hypothetical-protein
MSNENQNKKAAEKAKEVEEKLKDKKEEKTEDINQTKQDIQDTLN
>CP022898.1|AXJ48316.1|1042328_1043624_+|hypothetical-protein
MSFLRKHAEIIFSYLIGIVSLFTGLIILINLPLIKQLNGGKKVDTHVHNVWEFLNAFFSEIIKVMSRFIGNFPIVSAIVIIIFGILVMLIGHTLLRTIKYDYDISIFFLVIGIMYFIITLILMTQVYGFFAVIFIIPFTIHIGYIVYKDELNQENVKNHFMWIIVSYGISYLITQIALYGRIDANEIESIDILSVNAFFIIMWLLGQMAIWNFLFLRRALPLTKQELGEEEPELSRTSKGNVTNQTKIHLKQLQDKTTEYARKTRRSVDLDKIRAKRDKFKKKVNDIIDIQEDDIPDWMRKPKWVKPMYVELFCGVVIFLFTFLEFNNRNALFVSGDWKLSQTQYVIEWVTLLILLFIIIAYIATTLTFHLKGKFYYLQLFMGSILFFKLLTEFINIMIHGLLLSVFITPTLLLMLLAIIISYSLQLRERP
>CP022898.1|AXJ48317.1|1044048_1045254_+|Ribosomal-RNA-large-subunit-methyltransferase-I
MKIATLNKGKETKYFNGYPLIEEEDIYSQDHLKEEDIYSQDHLKEGDIFQIVTDKSQYVATAYVGRQHKGLGWVLTYDKAQEINTAFFVKLFKTALAERDYYFNIDGTNAFRLFNAEGDGVGGLTIDNYDGHLLIQWYSKGIYKFKYAILEAVRKVFDYKSIYEKVRFKDSEYSGGFVEGDAPEFPIVIEENFTFYNVDLEDGLMTGIFLDQKEVRKKLRNQYAKERHVLNLFSYTGAFSVIAASEASSTTSVDLANRSRSLTEENFGLNAIDPKSQYIYVMDTFDFYKYAARHGHSYDTIVIDPPSFARNKKRTFSVQKDYDKLINGALNILSSEGTLLLCTNASVYPLKQFKNTIKKTLEESGVDYELTEVMGLPKDFKTHPHYKPSKYLKAVFVNIRH
>CP022898.1|AXJ48318.1|1045307_1045850_+|hypothetical-protein
MGFKNNLTSNLTNKIGNSVFKIENINEKGAMPTTIKELNERRQRAEAIVKRKSLMSSTMSVVPIPGLDFGVDLKLMKDIIEDVNKIYGLDHKQVNSLGDDVKERVMSAAAIQGSQFIGKRISSAFLKIVIRDVAKRTAAKQTKWFPVVGQAVSASISYYFMNKIGKDHIQKCENVIKNVM
>CP022898.1|AXJ48319.1|1046003_1046270_+|Phosphocarrier-protein-HPr
MEQNSYVIIDETGIHARPATMLVQTASKFDSDIQLEYNGKKVNLKSIMGVMSLGVGKDAEITIYADGSDESDAIQAISDVLSKEGLTK
>CP022898.1|AXJ48320.1|1046272_1047991_+|Phosphoenolpyruvate-protein-phosphotransferase
MSKLIKGIAASDGVAIAKAYLLVEPDLTFDKNEKVTDVEGEVAKFNGAIEASKVELTKIRNNAEVQLGADKAAIFDAHLLVLDDPELIQPIQDKIKNENANAATALTDVTTQFVTIFESMDNEYMKERAADIRDVSKRVLSHILGVELPNPSMIDESVVIVGNDLTPSDTAQLNKEFVQGFATNIGGRTSHSAIMSRSLEIPAIVGTKSITQEVKQGDMIIVDGLNGDVIVNPTEDELIAYQDKRERYFADKKELQKLRDADTVTVDGVHAELAANIGTPNDLPGVIENGAQGIGLYRTEFLYMGRDQMPTEEEQFEAYKEVLEAMNGKRVVVRTLDIGGDKELSYLNLPEEMNPFLGYRAIRLCLAQQDIFRPQLRALLRASVYGKLNIMFPMVATINEFREAKAILLEEKENLKNEGHDISDDIELGIMVEIPATAALADVFAKEVDFFSIGTNDLIQYTLAADRMSERVSYLYQPYNPSILRLVKQVIEASHKEGKWTGMCGEMAGDETAIPLLLGLGLDEFSMSATSILKARRQINGLSKNEMTELANRAVDCATQEEVIELVNNYVK
>CP022898.1|AXJ48321.1|1048100_1048829_+|Transposase
MSIKPKVDIDVLLYMFQEYEKGVSFQYLIDTLQLDINVNTLYPKYKYYKTHGIETLLTQKQYNHYSKELKLKVVNEYLNSNQSTQDLAIKYNIRSSTQVKNWIKMYTVGKEIKNQSPKTGVYIMKARKTTFEERVTIVEYYLNHKQSYREVAEHFNISYGQIYQWVQKYQAHGKNGLVDGRGKGKPKSMMTPEEQKEAEIQALKAQNRLLEMENDVLKKFQALEREMIQRENKSRHTKRLKR
>CP022898.1|AXJ48322.1|1048852_1049641_+|Integrase-core-domain-protein
MCRILGISRASYYKWVHYQSSELELENEQLKREIESIYHKYNGIYGYRRIYIYIRLKLGKQVNRKRIYRLMKELNLKAVIRQKRKPYRRSTPQITSENKLNRQFDIDTPNKVWLTDVTEFKIKEGSKIYLSAIYDLGVKRIVSYKLGPSNNNQLVFKTFNQAIEKVENTKGILFHSDRGFQYTSKTFKHMLDECGMIQSMSRVSKCIDNGPMEGVWGTIKSEIFRGNKHFKFNSVEEATKTIHDFILFFNHERITLKMADSV
>CP022898.1|AXJ48323.1|1049890_1050124_-|glutaredoxin-3
MSEIIVYTQNDCPPCTFVKNYLNEHQIDFEERNINNQQYRNEMIDFDAFSTPFILLNGNPMYHVDLDEINKVLNIQD
>CP022898.1|AXJ48324.1|1050321_1051683_+|Putative-cytochrome-bd-menaquinol-oxidase-subunit-I
MDTVEISRFLTAMTLAVHIIFATIGVGMPLMFAIAEFLGIRKNDLQYIAMAKRWAKAYTITVAVGVVTGTIIGLQLSLIWPTFMEMGGHVIALPLFMETFAFFFEAIFLSIYLYTWDRFKNKWTHFLISIPVIIGGSFSAFFITSVNSFMNTPAGFELKNGKMVNVQPIEAMFNPSFIVRSFHVITTAGMTMAFVIASIAAFKLLRNRQPKDTVYHKKALKMSMIVGFFSTLLSMLAGDLSAKFLHKFQPEKLAAYEWHFDTSSHAKLLLFGVLDEKTQQVKGAIELPGLLSFLADNSVKTKVQGLNDFPKSLHPPMIVHYFFDLMVTMGILCFVISGVYVLTLMFKKLRKFSTHKWMLYGILLTGPASMLAIEFGWFLTEMGRQPWIVRGYMRVAEAATQAGGITFVTILFGVLYIILMYTCAYVLIRMFKNKPAYEDVNRLAKKQGGEIEK

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Crispr_ID: CP022898_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022898_3

1768189-1768271

Orphan

Consensus_repeat	Method
TGCAAGTTGGGGTGGGGCCCCAACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022898_3

>merge|CP022898|3|1768189-1768271|CRISPRCasFinder
TGCAAGTTGGGGTGGGGCCCCAACACAGAAGGTGACGTAATGTCAACTTACTATAATGTGCAAGTTGGGGTAGGGCCCCAACA

>CP022898|3|3|1768189-1768271|CRISPRCasFinder
TGCAAGTTGGGGTGGGGCCCCAACA	CAGAAGGTGACGTAATGTCAACTTACTATAATG
TGCAAGTTGGGGTAGGGCCCCAACA

Protein	Signature genes	Signature genes Name	Protein_function
CP022898.1\|AXJ48967.1\|1769817_1770231_+\|Stress-response-protein-NhaX	unknown	unknown	gnl\|CDD\|366180
CP022898.1\|AXJ48970.1\|1772852_1773971_-\|Alanine-dehydrogenase-2	unknown	unknown	gnl\|CDD\|240630
CP022898.1\|AXJ48958.1\|1755348_1756710_+\|D-serine/D-alanine/glycine-transporter	unknown	unknown	gnl\|CDD\|224038
CP022898.1\|AXJ48960.1\|1758838_1759807_-\|6-phosphofructokinase	unknown	unknown	gnl\|CDD\|235111
CP022898.1\|AXJ48961.1\|1760075_1761020_-\|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-alpha	unknown	unknown	gnl\|CDD\|235580
CP022898.1\|AXJ48963.1\|1762071_1763301_-\|NAD-dependent-malic-enzyme	unknown	unknown	gnl\|CDD\|235976
CP022898.1\|AXJ48974.1\|1777217_1777712_-\|putative-thiol-peroxidase	unknown	unknown	gnl\|CDD\|179055
CP022898.1\|AXJ48957.1\|1753879_1755001_-\|Citrate-synthase-2	unknown	unknown	gnl\|CDD\|184468
CP022898.1\|AXJ48969.1\|1771482_1772538_+\|putative-peptidase	unknown	unknown	gnl\|CDD\|223085
CP022898.1\|AXJ48966.1\|1768314_1769613_-\|Cobalt-dependent-inorganic-pyrophosphatase	unknown	unknown	gnl\|CDD\|226594
CP022898.1\|AXJ48959.1\|1757059_1758817_-\|Pyruvate-kinase	unknown	unknown	gnl\|CDD\|235784
CP022898.1\|AXJ48962.1\|1761019_1761877_-\|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
CP022898.1\|AXJ48964.1\|1763752_1766950_-\|DNA-polymerase-III-subunit-alpha	unknown	unknown	gnl\|CDD\|223660
CP022898.1\|AXJ48972.1\|1774857_1776060_-\|Acetate-kinase	unknown	unknown	gnl\|CDD\|234680
CP022898.1\|AXJ48973.1\|1776147_1777095_-\|N-6-DNA-Methylase	unknown	unknown	gnl\|CDD\|223897
CP022898.1\|AXJ48971.1\|1774111_1774612_+\|Putative-universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
CP022898.1\|AXJ48968.1\|1770618_1771308_-\|metal-dependent-hydrolase	unknown	unknown	gnl\|CDD\|234811
CP022898.1\|AXJ48975.1\|1777809_1778580_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182593
CP022898.1\|AXJ48965.1\|1766970_1767912_-\|Bifunctional-oligoribonuclease-and-PAP-phosphatase-NrnA	unknown	unknown	gnl\|CDD\|223691
CP022898.1\|AXJ48956.1\|1752562_1753831_-\|Isocitrate-dehydrogenase-[NADP]	unknown	unknown	gnl\|CDD\|180792

Protein	Function_ID	Function_description	E-value
CP022898.1\|AXJ48967.1\|1769817_1770231_+\|Stress-response-protein-NhaX	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	6.00154e-19
CP022898.1\|AXJ48970.1\|1772852_1773971_-\|Alanine-dehydrogenase-2	gnl\|CDD\|240630	cd05305, L-AlaDH, Alanine dehydrogenase NAD-binding and catalytic domains. Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.	0
CP022898.1\|AXJ48958.1\|1755348_1756710_+\|D-serine/D-alanine/glycine-transporter	gnl\|CDD\|224038	COG1113, AnsP, Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism].	0
CP022898.1\|AXJ48960.1\|1758838_1759807_-\|6-phosphofructokinase	gnl\|CDD\|235111	PRK03202, PRK03202, ATP-dependent 6-phosphofructokinase.	0
CP022898.1\|AXJ48961.1\|1760075_1761020_-\|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-alpha	gnl\|CDD\|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	0
CP022898.1\|AXJ48963.1\|1762071_1763301_-\|NAD-dependent-malic-enzyme	gnl\|CDD\|235976	PRK07232, PRK07232, bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed.	0
CP022898.1\|AXJ48974.1\|1777217_1777712_-\|putative-thiol-peroxidase	gnl\|CDD\|179055	PRK00522, tpx, thiol peroxidase.	5.93419e-100
CP022898.1\|AXJ48957.1\|1753879_1755001_-\|Citrate-synthase-2	gnl\|CDD\|184468	PRK14035, PRK14035, citrate synthase; Provisional.	0
CP022898.1\|AXJ48969.1\|1771482_1772538_+\|putative-peptidase	gnl\|CDD\|223085	COG0006, PepP, Xaa-Pro aminopeptidase [Amino acid transport and metabolism].	2.79772e-126
CP022898.1\|AXJ48966.1\|1768314_1769613_-\|Cobalt-dependent-inorganic-pyrophosphatase	gnl\|CDD\|226594	COG4109, COG4109, Predicted transcriptional regulator containing CBS domains [Transcription].	0
CP022898.1\|AXJ48959.1\|1757059_1758817_-\|Pyruvate-kinase	gnl\|CDD\|235784	PRK06354, PRK06354, pyruvate kinase; Provisional.	0
CP022898.1\|AXJ48962.1\|1761019_1761877_-\|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
CP022898.1\|AXJ48964.1\|1763752_1766950_-\|DNA-polymerase-III-subunit-alpha	gnl\|CDD\|223660	COG0587, DnaE, DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].	0
CP022898.1\|AXJ48972.1\|1774857_1776060_-\|Acetate-kinase	gnl\|CDD\|234680	PRK00180, PRK00180, acetate kinase A/propionate kinase 2; Reviewed.	0
CP022898.1\|AXJ48973.1\|1776147_1777095_-\|N-6-DNA-Methylase	gnl\|CDD\|223897	COG0827, COG0827, Adenine-specific DNA methylase [DNA replication, recombination, and repair].	3.79172e-57
CP022898.1\|AXJ48971.1\|1774111_1774612_+\|Putative-universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.27306e-36
CP022898.1\|AXJ48968.1\|1770618_1771308_-\|metal-dependent-hydrolase	gnl\|CDD\|234811	PRK00685, PRK00685, metal-dependent hydrolase; Provisional.	2.522e-133
CP022898.1\|AXJ48975.1\|1777809_1778580_-\|hypothetical-protein	gnl\|CDD\|182593	PRK10621, PRK10621, hypothetical protein; Provisional.	6.72678e-38
CP022898.1\|AXJ48965.1\|1766970_1767912_-\|Bifunctional-oligoribonuclease-and-PAP-phosphatase-NrnA	gnl\|CDD\|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	9.95606e-99
CP022898.1\|AXJ48956.1\|1752562_1753831_-\|Isocitrate-dehydrogenase-[NADP]	gnl\|CDD\|180792	PRK07006, PRK07006, isocitrate dehydrogenase; Reviewed.	0

>CP022898.1|AXJ48965.1|1766970_1767912_-|Bifunctional-oligoribonuclease-and-PAP-phosphatase-NrnA
MISTLNEIMKCIEDNDTIIIHRHVRPDPDAYGSQLGLKYYIQQKFPQKQVFAVGEAESSLSFIGELDNIDDKTYQDALVIVCDTANAPRIDDERYSTGSKLIKIDHHPAVDQYGDINLVNTNASSTSEIIYDLISHFNDEAIVNKDIASVLYLGIVGDTGRFLFNNTSEHTMEIAGKLIGHDIDHNALLNKMMEKDPKMLPFQGYVLQHFELMDDGFCQVKITEDVLEQFGIQPNEASQFVNTIADIKGLKIWVFAVDEGSEIRCRLRSKGQLIINDIAQDFGGGGHPNASGVSVNSWDEFEQLATALRTKLN
>CP022898.1|AXJ48964.1|1763752_1766950_-|DNA-polymerase-III-subunit-alpha
MVAYLNIHTAYDLLNSSLKIEDAVRLAVSENVEALAITDTNVLYGFPKFYDACIANNIKPIFGMTIYVTNGLNTIETVVLAKDNNGLKDLYQLSSKIKMNSMENVSFELLQQFSSNLIIIFKNVADEHRDIVQVFDSHEDTYLDHQSVLVQGIKHVWIQNVCYQTRQDADTISALAAIRDNTKLDLIHDQEDFGAHFLTEKEIKQLDINQEYLTQVDVIAQKCNAELKYHQSLLPQYQTPNDESAKKYLWRVLVTQLKKLELNYDVYLERLKYEYKVITNMGFEDYFLIVSDLIHYAKTNDVMVGPGRGSSAGSLVSYLLGITTIDPIKFNLLFERFLNPERVTMPDIDIDFEDTRRERVIQYVQEKYGELHVSGIVTFGHLLARAVARDVGRIMGFDEVTLNEISSLIPHKLGITLDEAYQIDDFKKFVHRNHRHERWFSICKKLEGLPRHTSTHAAGIIINDHPLYEYAPLTKGDTGLLTQWTMTEAERIGLLKIDFLGLRNLSIIHQILTQVKKDLGINIDIEKIPFDNQKVFELLSQGDTTGIFQLESDGVRSVLKKLKPEHFEDIVAVTSLYRPGPMEEIPTYITRRHDPSKVQYLHPHLEPILKNTYGVIIYQEQIMQIASTFANFSYGEADILRRAMSKKNRAVLESERQHFIEGAKQNGYHEDISKQIFDLILKFADYGFPRAHAVSYSKIAYIMSFLKVHYPNYFYANILSNVIGSEKKTAQMIEEAKKQGITILPPNINESHWFYKPSQEGIYLSIGTIKGVGYQSVKVIVDERYQNGKFKDFFDFARRIPKRVKTRKLLEALILVGAFDAFGKTRSTLLQAIDQVLDGDLNIEQDGFLFDILTPKQMYEDKEELPDALISQYEKEYLGFYVSQHPVDKKFVAKQYLTIFKLSNAQNNKPILVQFDKVKQIRTKNGQNMAFVTLNDGIETLDGVIFPNQFKKYEELLSHNDLFIVSGKFDHRKQQRQLIINEIQTLATFEEQKLAFAKQIIIRNKSQIDMFEEMIKATKENANDVVLSFYDETIKQMTTLGYINQKDSMFNNFIQSFNPSDIRLI
>CP022898.1|AXJ48963.1|1762071_1763301_-|NAD-dependent-malic-enzyme
MSLRDEALEMHKRNQGKLEVKPNVKVTNKEELSLAYSPGVAEPCKDIYEDKRKVYDYTIKGNTVAVITDGTAVLGLGNIGPEASIPVMEGKAVLFKSFAGINGVPIALNTTDTEEIIKTVKLLEPNYGGINLEDISAPRCFEIEERLKKETNIPVFHDDQHGTAIVTIAGLVNALRVVNKDIAKIKVVLNGAGAAGIAIVKLLYAYGVRNMVMCDSRGAIFEGRSYGMNPTKDVVAKWTNKDKIEGSLEEVVKDADVFIGVSVANALSQDMVKSMADNPIIFAMANPNPEIIPDDAKAAGARVVGTGRSDYPNQINNVLAFPGIFRGALEVEATHINEEMKKAAVEAIADLIDSSELNEDYCIPGPFDKRVAPSVARNVAKAAMESGVARIEVDPQDVYDKTMKLTDLQ
>CP022898.1|AXJ48962.1|1761019_1761877_-|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-beta
MFKDFFNRTKKKKYLTVQDSKNNDVPAGIMTKCPKCKKIMYTKELAENLNVCFNCDHHIALTAYKRIEAISDEGSFTEFDKGMTSANPLDFPSYLEKIEKDQQKTGLKEAVVTGTAQLDGMKFGVAVMDSRFRMGSMGSVIGEKICRIIDYCTENRLPFILFSASGGARMQEGIISLMQMGKTSVSLKRHSDAGLLYISYLTHPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVVHRNDMRQTLSEILKIHQEVTK
>CP022898.1|AXJ48961.1|1760075_1761020_-|Acetyl-coenzyme-A-carboxylase-carboxyl-transferase-subunit-alpha
MLDFEKPLFEIRNKIESLKESQDKNDVDLQEEIDMLEASLERETKKIYTNLKPWDRVQIARLQERPTTLDYIPYIFDSFMELHGDRNFRDDPAMIGGIGFLNGRAVTVIGQQRGKDTKDNIYRNFGMAHPEGYRKALRLMKQAEKFNRPIFTFIDTKGAYPGKAAEERGQSESIATNLIEMASLKVPVIAIVIGEGGSGGALGIGIANKVLMLENSTYSVISPEGAAALLWKDSNLAKIAAETMKITAHDIKQLGIIDDVISEPLGGAHKDIEQQALAIKSAFVEQLDSLESLSRDEIANDRFEKFRNIGSYIE
>CP022898.1|AXJ48960.1|1758838_1759807_-|6-phosphofructokinase
MKKIAVLTSGGDSPGMNAAVRAVVRTAIYNEIEVYGVYHGYQGLLNDDIHKLELGSVGDTIQRGGTFLYSARCPEFKEQEVRKVAIENLRKRGIEGLVVIGGDGSYRGAQRISEECKEIQTIGIPGTIDNDINGTDFTIGFDTALNTIIGLVDKIRDTASSHARTFIIEAMGRDCGDLALWAGLSVGAETIVVPEVKTDIKEIADKIEQGIKRGKKHSIVLVAEGCMTAQDCQKELSQYINVDNRVSVLGHVQRGGSPTGADRVLASRLGGYAVDLLMQGETAKGVGIKNNKIVATSFDEIFDGKDHKFDYSLYELANKLSI
>CP022898.1|AXJ48959.1|1757059_1758817_-|Pyruvate-kinase
MRKTKIVCTIGPASESEEMIEKLINAGMNVARLNFSHGSHEEHKGRIDTIRKVAKRLDKIVAILLDTKGPEIRTHNMKDGIIELERGNEVIVSMNEVEGTPEKFSVTYENLINDVQVGSYILLDDGLIELQVKDIDHAKKEVKCDILNSGELKNKKGVNLPGVRVSLPGITEKDAEDIRFGIKENVDFIAASFVRRPSDVLEIREILEEQKANISVFPKIENQEGIDNIAEILEVSDGLMVARGDMGVEIPPEKVPMVQKDLIRQCNKLGKPVITATQMLDSMQRNPRATRAEASDVANAIYDGTDAVMLSGETAAGLYPEEAVKTMRNIAVSAEAAQDYKKLLSDRTKLVETSLVNAIGISVAHTALNLNVKAIVAATESGSTARTISKYRPHSDIIAVTPSEETARQCSIVWGVQPVVKKGRKSTDALLNNAVATAVETGRVTNGDLIIITAGVPTGETGTTNMMKIHLVGDEIANGQGIGRGSVVGTTLVAETVKDLEGKDLSDKVIVTNSIDETFVPYVEKALGLITEENGITSPSAIVGLEKGIPTVVGVEKAVKNISNNMLVTIDAAQGKIFEGYANVL
>CP022898.1|AXJ48958.1|1755348_1756710_+|D-serine/D-alanine/glycine-transporter
MAEKLQRELSNRHIQLIAIGGAIGTGLFLGAGQTIALTGPSILLTYIIIGFMLFMFMRGLGEIIIQNTEFKSFADVTNTYIGPFAGFVTGWTYWFCWIITGMAEVTAVAKYVSFWFPEIPNWISALFCVLLLMSFNLLSARLFGELEFWFSIIKIATIIGLIVVGFVMILFAFKTQFGHASFTNLYEHGIFAKGASGFFMSFQMALFSFVGIEMIGVTAGETKDPVKTIPKAINSVPIRILIFYVGALAVIMSIIPWQQVDPDNSPFVKLFALIGIPFAAGLINFVVLTAAASSCNSGIFSNSRMLFGLSSQQQAPPNFSKTNKYGVPHVAIFASSALLLVAALLNYIFPDATKVFTYVTTISTVLFLVVWGLIIIAYINYSRKNPDLHKNATYKLLGGKYMGYLIFVFFIFVFGLLFINVDTRRAIYFIPIWFILLAFMYLRYKRIAAKSNK
>CP022898.1|AXJ48957.1|1753879_1755001_-|Citrate-synthase-2
MAELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEELAHLKGKLNQYMTLNPRVYTHFEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYERAMRIQAKVASLVTAFARVRQDKEPLKPNPDLSYAANFLYMLRGELPTDIEVEAFNKALILHADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVDAYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAEEKGLIPNVDFYSASVYHCMEIPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIGETNRKYIPLEERK
>CP022898.1|AXJ48956.1|1752562_1753831_-|Isocitrate-dehydrogenase-[NADP]
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK
>CP022898.1|AXJ48966.1|1768314_1769613_-|Cobalt-dependent-inorganic-pyrophosphatase
MTKHEQILDYIESLSIGSKISVRKIAKFLNVSEGTAYRAIKDADKMGMVATIDRVGTVRIEKRNRNEIEHLTFNEIVNIIDGQVLGGNKGITKMVSKFAIGAMELKDILKYIGPKTLLIVGNREDVQIEALKRGTAILITGGFKPSNKVINFANEHDLPVLSSSYDTFLVANIINKALFNQKIRKDILIVQDIMTPLDDLSVLFDTMKIADYKRMANRTGHTRFPVVNESYKLVGIVTSREMINTKDDDEIDKVMTRNPIYVNAMSTVASCAHMMIWEGIELIPVVSSNKKTVGVINRQDVLKSMQLLGRQPQMGETINDQIAKYITMNQDGITVEVSPLLINHYGTVSKAAFVSIIEETIQYEMRKFKKGNVMIENLNIVYIKTVPIESHITVRFGILDVGRNFAKIEVNMHSQNDKVASALVICQMFDEV
>CP022898.1|AXJ48967.1|1769817_1770231_+|Stress-response-protein-NhaX
MYKNILLGVDTQLKNEKALKEVSKLAGEGTVVTVLNAISEQDAQASIKAGVHLNKLTEERSKRLEKTRKALEDYGIDYDQIIVRGNAKEELLKHANSGKYEIVVLSNRKAEDKKKFVLGSVSHKVAKRATIPVLIVK
>CP022898.1|AXJ48968.1|1770618_1771308_-|metal-dependent-hydrolase
MKLSFHGQSTIYLEGNNKKVIVDPFISNNPKCDLNIETVQVDYIVLTHGHFDHFGDVVELAKNTGATVIGSAEMADYLSSYHGVENVHGMNIGGKANFDFGSVKFVQAFHSSSFTHENGIPVYLGMPMGIVFEVEGKTIYHTGDTGLFSDMSLIAKRHPVDVCFVPIGDNFTMGIDDASYAINEFIKPKISVPIHYDTFPLIEQDPQQFKDAVNVGDVQILKPGESVQF
>CP022898.1|AXJ48969.1|1771482_1772538_+|putative-peptidase
MTKISKIIDELNNQQADAAWITTPLNVYYFTGYRSEPHERLFALLIKKDGKQVLFCPKMEVEEVKASPFTGEIVGYLDTENPFSLYPQTINKLLIESEHLTVARQKQLISGFNVNSFGDIDLTIKQLRNIKSEDEISKIRKAAELADKCIEIGVSYLKEGVTEREVVNHIEQTIKQYGVNEMSFDTMVLFGDHAASPHGTPGDRRLKSNEYVLFDLGVIYEHYCSDMTRTIKFGEPNKEAQEIYNIVLEAETSAIQAIKPGIPLKDIDHIARNIISEKGYGEYFPHRLGHGLGLQEHEYQDVSSTNSNLLEAGMVITIEPGIYVPGVAGVRIEDDILVTNEGFEVLTHYEK
>CP022898.1|AXJ48970.1|1772852_1773971_-|Alanine-dehydrogenase-2
MKIGIPREIKNNENRVGLSPSGVHALVESGHTVLVETNAGSGSFFEDVDYKEAGAEIVAEQAKVWDVDMVIKVKEPLESEYPYFKEGLVLFTYLHLANEDKLTQALIDRKVISIAYETVQLPDRSLPLLSPMSEVAGRMSAQVGAEFLQKLNGGMGILLGGVPGVPKGKVTIIGGGQAGTNAAKIALGLGADVTILDVNPKRLQQLDDLFGGRVHTIMSNPLNIELYVKQSDLVIGAVLIPGAKAPRLVTEDMIKQMKNGSVIIDIAIDQGGIFETTDKITTHDDPTYIKHGVVHYAVANMPGAVPRTSTLALNNATLPYALMLANKGYREAFKSNQPLSLGLNTYKGHVTNKGVAEAFEMEYKSVEEALQL
>CP022898.1|AXJ48971.1|1774111_1774612_+|Putative-universal-stress-protein
MITYKNILIAVDGSHEAEWAFNRAVGVAKRNDAKLTIVNVIDSRTYSSYEVYDAQFTEKSKHFAEELLNGYKEVATNAGVKDVETRLEFGSPKSIIPKKLAHEINADLIMSGTSGLNAVERFIVGSVSESIVRHAPCDVLVVRTEELPADFQPQVATTQLREKYQN
>CP022898.1|AXJ48972.1|1774857_1776060_-|Acetate-kinase
MSKLILAINAGSSSLKFQLIRMPEEELVTKGLVERIGLKDSIFTIEVNGEKVKTVQDIKDHVEAVDIMLDAFKAHNIINDINDIDGTGHRVVHGGEKFPESVAITDEVEKEIEELSELAPLHNPANLMGIRAFRKLLPNIPHVAIFDTAFHQTMPEKAYLYSLPYHYYKDYGIRKYGFHGTSHKFVSQRAAEMLDKPIEDLRIISCHIGNGASIAAIDGGKSIDTSMGFTPLAGVTMGTRSGNIDPALIPFIMEKTGKTAEQVLEILNKESGLLGLSGTSSDLRDLSEEAESGKARSQMALDVFASKIHKYIGSYAARMHGVDVIVFTAGIGENSVEIRAKVLEGLEFMGVYWDPKKNENLLRGKEGFINYPHSPVKVVVIPTDEESMIARDVMTFGGLK
>CP022898.1|AXJ48973.1|1776147_1777095_-|N-6-DNA-Methylase
MAEQQTIMERLFHTLDEKAKTLNNENGQSFIENLGLAMEQVYTNERGLLEQSTLQDRRKAFQFAYLSLMQEEKIQANHQITPDSIGLILGFLVERFMNNQEELHIVDIASGAGHLSATVKEVLPEIAVMHHLIEVDPVLSRVSVHLANFLEIPFDVYPQDAIMPLPLEEADIVIGDFPVGYYPIDERSKEFKLGFEEGHSYSHYLLIEQAINALKDAGYAFLVVPSNIFTGEHVKQLEKYIATETEMQAFLNLPPTLFKNEKARKSILILQKKKSGETKPVEVLLANIPDFKNPSQFQGFMTELNQWMDTNRPKK
>CP022898.1|AXJ48974.1|1777217_1777712_-|putative-thiol-peroxidase
MTEITFKGGPIHLKGQQINEGDFAPDFTVLDNDLNQVTLADYAGKKKLISVVPSIDTGVCDQQTRKFNSEASKEEGIVLTISADLPFAQKRWCASAGLDNVITLSDHRDLSFGENYGVVMEELRLLARAVFVLDADNKVVYKEIVSEGTDFPDFDAALAAYKNI
>CP022898.1|AXJ48975.1|1777809_1778580_-|hypothetical-protein
MDLNLTMIIIIILFGFIAAFIDSVVGGGGLISTPALLAIGLPPSVALGTNKLASSFGSLTSTIKFIRSGKVDLYVVAKLFGFVFLASACGAYIATMVPSQILKPLIIIALSSVFIFTLLKKDWGNTRTFTQFTFKKAILFAALFILIGFYDGFVGGGTGSFMLFVLLVFGFDFLSAAGNAKVLNFASNIGALVLFMVLGQVDYVIGLIMASSMIAGSYTGAHFAIKQGVGYVKVLFIIITAILILKNAFDYIQQFL

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Crispr_ID: CP022898_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022898_4

2083794-2083873

Orphan

Consensus_repeat	Method
GGCCCCACCCCAACTTACATTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022898_4

>merge|CP022898|4|2083794-2083873|CRISPRCasFinder
GGCCCCACCCCAACTTACATTGTTTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGGGGCCCCACCCCAACTTGCATTGT

>CP022898|4|4|2083794-2083873|CRISPRCasFinder
GGCCCCACCCCAACTTACATTGT	TTGTAGAATTTCTTTTCGAAATTCTCTGTGTTGG
GGCCCCACCCCAACTTGCATTGT

Protein	Signature genes	Signature genes Name	Protein_function
CP022898.1\|AXJ49274.1\|2084013_2085321_+\|Ktr-system-potassium-uptake-protein-B	unknown	unknown	gnl\|CDD\|273349
CP022898.1\|AXJ49270.1\|2078095_2079151_-\|putative-leukocidin-like-protein-2-precursor	unknown	unknown	gnl\|CDD\|369625
CP022898.1\|AXJ49282.1\|2092480_2093266_+\|2-oxoglutaramate-amidase	unknown	unknown	gnl\|CDD\|143607
CP022898.1\|AXJ49268.1\|2075702_2076545_+\|Phospholipase-C-precursor	unknown	unknown	gnl\|CDD\|132436
CP022898.1\|AXJ49271.1\|2079586_2080810_+\|putative-succinyl-diaminopimelate-desuccinylase	unknown	unknown	gnl\|CDD\|181490
CP022898.1\|AXJ49264.1\|2073541_2073724_+\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49278.1\|2088930_2089215_-\|10-kDa-chaperonin	unknown	unknown	gnl\|CDD\|178988
CP022898.1\|AXJ49272.1\|2081307_2082177_-\|EamA-like-transporter-family-protein	unknown	unknown	gnl\|CDD\|273359
CP022898.1\|AXJ49266.1\|2073902_2074517_-\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49265.1\|2073780_2073906_+\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49283.1\|2094179_2094797_+\|Accessory-gene-regulator-protein-B	unknown	unknown	gnl\|CDD\|214819
CP022898.1\|AXJ49275.1\|2085892_2086519_-\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49273.1\|2082179_2083382_-\|5-aminolevulinate-synthase	unknown	unknown	gnl\|CDD\|236370
CP022898.1\|AXJ49269.1\|2077057_2078074_-\|putative-leukocidin-like-protein-1-precursor	unknown	unknown	gnl\|CDD\|369625
CP022898.1\|AXJ49277.1\|2087238_2088855_-\|60-kDa-chaperonin	unknown	unknown	gnl\|CDD\|234573
CP022898.1\|AXJ49281.1\|2091502_2092129_+\|Nitroreductase-family-protein	unknown	unknown	gnl\|CDD\|226090
CP022898.1\|AXJ49280.1\|2090157_2091306_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|275319
CP022898.1\|AXJ49267.1\|2074624_2075662_+\|Tyrosine-recombinase-XerC	unknown	unknown	gnl\|CDD\|271189
CP022898.1\|AXJ49276.1\|2086515_2086695_-\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49279.1\|2089389_2090133_+\|CAAX-amino-terminal-protease-self--immunity	unknown	unknown	gnl\|CDD\|376806

Protein	Function_ID	Function_description	E-value
CP022898.1\|AXJ49274.1\|2084013_2085321_+\|Ktr-system-potassium-uptake-protein-B	gnl\|CDD\|273349	TIGR00933, Trk_system_potassium_uptake_protein_trkH., potassium uptake protein, TrkH family. The proteins of the Trk family are derived from Gram-negative and Gram-positive bacteria, yeast and wheat. The proteins of E. coli K12 TrkH and TrkG as well as several yeast proteins have been functionally characterized.The E. coli TrkH and TrkG proteins are complexed to two peripheral membrane proteins, TrkA, an NAD-binding protein, and TrkE, an ATP-binding protein. This complex forms the potassium uptake system. [Transport and binding proteins, Cations and iron carrying compounds].	9.80292e-81
CP022898.1\|AXJ49270.1\|2078095_2079151_-\|putative-leukocidin-like-protein-2-precursor	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	1.31423e-77
CP022898.1\|AXJ49282.1\|2092480_2093266_+\|2-oxoglutaramate-amidase	gnl\|CDD\|143607	cd07583, nitrilase_5, Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases). The nitrilase superfamily is comprised of nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes, which depend on a Glu-Lys-Cys catalytic triad. This superfamily has been classified in the literature based on global and structure based sequence analysis into thirteen different enzyme classes (referred to as 1-13). Class 13 represents proteins that at the time were difficult to place in a distinct similarity group; this subgroup represents either a new class or one that was included previously in class 13. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer.	2.11308e-126
CP022898.1\|AXJ49268.1\|2075702_2076545_+\|Phospholipase-C-precursor	gnl\|CDD\|132436	TIGR03395, Sphingomyelinase_C, sphingomyelin phosphodiesterase. Members of this family are bacterial proteins that act as sphingomyelin phosphodiesterase (EC 3.1.4.12), also called sphingomyelinase. Some members of this family have been shown to act as hemolysins. [Cellular processes, Pathogenesis].	1.47531e-123
CP022898.1\|AXJ49271.1\|2079586_2080810_+\|putative-succinyl-diaminopimelate-desuccinylase	gnl\|CDD\|181490	PRK08588, PRK08588, succinyl-diaminopimelate desuccinylase; Reviewed.	0
CP022898.1\|AXJ49269.1\|2077057_2078074_-\|putative-leukocidin-like-protein-1-precursor	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	7.62134e-98
CP022898.1\|AXJ49272.1\|2081307_2082177_-\|EamA-like-transporter-family-protein	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	2.86916e-09
CP022898.1\|AXJ49278.1\|2088930_2089215_-\|10-kDa-chaperonin	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	1.20776e-44
CP022898.1\|AXJ49283.1\|2094179_2094797_+\|Accessory-gene-regulator-protein-B	gnl\|CDD\|214819	smart00793, AgrB, Accessory gene regulator B. The accessory gene regulator (agr) of Staphylococcus aureus is the central regulatory system that controls the gene expression for a large set of virulence factors. The arg locus consists of two transcripts: RNAII and RNAIII. RNAII encodes four genes (agrA, B, C, and D) whose gene products assemble a quorum sensing system. At low cell density, the agr genes are continuously expressed at basal levels. A signal molecule, autoinducing peptide (AIP), produced and secreted by the bacteria, accumulates outside of the cells. When the cell density increases and the AIP concentration reaches a threshold, it activates the agr response, i.e. activation of secreted protein gene expression and subsequent repression of cell wall-associated protein genes. AgrB and AgrD are essential for the production of the autoinducing peptide which functions as a signal for quorum sensing. AgrB is a transmembrane protein. AgrB is involved in the proteolytic processing of AgrD and may have both proteolytic enzyme activity and a transporter facilitating the export of the processed AgrD peptide.	1.96935e-48
CP022898.1\|AXJ49273.1\|2082179_2083382_-\|5-aminolevulinate-synthase	gnl\|CDD\|236370	PRK09064, PRK09064, 5-aminolevulinate synthase; Validated.	0
CP022898.1\|AXJ49277.1\|2087238_2088855_-\|60-kDa-chaperonin	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
CP022898.1\|AXJ49281.1\|2091502_2092129_+\|Nitroreductase-family-protein	gnl\|CDD\|226090	COG3560, FMR2, Predicted oxidoreductase related to nitroreductase [General function prediction only].	5.0673e-115
CP022898.1\|AXJ49267.1\|2074624_2075662_+\|Tyrosine-recombinase-XerC	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	4.6482e-25
CP022898.1\|AXJ49280.1\|2090157_2091306_-\|hypothetical-protein	gnl\|CDD\|275319	TIGR04526, predic_Ig_block, putative immunoglobulin-blocking virulence protein. Members of this family are putative virulence proteins of Mycoplasma and Ureaplasma species. Members share a region of sequence similarity (see TIGR04524) with protein M, a Mycoplasma genitalium protein that binds a conserved light chain region of IgG and blocks its protective function of antigen-specific binding. The seed alignment for this model includes an N-terminal signal-anchor domain and a proline-rich linker domain, and a C-terminal extension, in addition to the protein M-like domain recognized by TIGR04524. [Cellular processes, Pathogenesis].	1.67862e-06
CP022898.1\|AXJ49279.1\|2089389_2090133_+\|CAAX-amino-terminal-protease-self--immunity	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	2.23687e-11

>CP022898.1|AXJ49273.1|2082179_2083382_-|5-aminolevulinate-synthase
MYKTLFFDKIAELKEKGSYRIFTEINRIANKYPLAKGEDGKEVVVFCSNDYLGMSQNQEVINVMSDALKEYGAGAGGSRNIGGSHKYFKLLENEIAKWHKKDSALVFPTGYSSNDAALQGLLRIFPEMIVFSDSKNHASIINALRSVKNKIEIFEHNNVKHLNELLNQYDINIPKLIVFESVYSMDGDIAPIVEIVELAKEYNSLTFLDEVHAIGMYGEEGRGYSDVVGVQEDIDIIQSTMAKGIGIIGGYITGDQLLIDVIRSYSSGFIFTTALPPVIAAGCLTSIKIVRSNDKLREELQDKTKYLKEKFKENGIEVLKQSKTHILPVIIGDSKKCEEAAKLLLDKFNIYVQAINSPTVEIGTERFRINVTPNHTKEQMDLLVSSIVYVFDFLNIRRSV
>CP022898.1|AXJ49272.1|2081307_2082177_-|EamA-like-transporter-family-protein
MNYLMYLFCMFIWGLNFIAVKIQGDSLPLEVALLYRSLIAFSLFGVMFIFIFKKLKLNNTNWFTIIGFGLCNFTISYLLLYYGTFYSSAAIVTLIFSMKAILTPIFISMVFKRKISNRIYIGGGLGVVSVVVILYPDLNSLTNEFIIGVAFALLGTIITSIGDVLSLYNSESKVHPVLSNTIGMLSAVIFLLIYTSFKGYRYSFPLELNFWFGLLYLSILASFLAWFFYLKLINNIGAAESGYMVAMFPAIGGIASVIMGETHLSINLVVGIILACMGAYLALYKPKPS
>CP022898.1|AXJ49271.1|2079586_2080810_+|putative-succinyl-diaminopimelate-desuccinylase
MTTFSEKEKIQLLADIVELQTENNNEIDVCNYLKDLFDKYDIKSEILKVNEHRANIVAEIGNGSPILALSGHMDVVDAGNQDNWTYPPFQLTEKDGKLYGRGTTDMKGGLMALVITLIELKEQNQLPQGTIRLLATAGEEKEQEGAKLLADKGYLDDVDGLIIAEPTGSGIYYAHKGSMSCKVTATGKAVHSSVPFIGDNAIDTLLEFYNQFKEKYSELKKHDTKHELDVAPMFKSLIGKEISEEDANYASGLTAVCSIINGGKQFNSVPDEASLEFNVRPVPEYDNDFIESFFQNIINNVNSNKLSLDIPSNHRPVTSDKNSKLITTIKDVASSYVNKDDIFVSALVGATDASSFLGDNKDNVDLAIFGPGNPLMAHQIDEYIEKDMYLKYIDIFKEASIQYLKEK
>CP022898.1|AXJ49270.1|2078095_2079151_-|putative-leukocidin-like-protein-2-precursor
MKNKKRVLIASSLSCAILLLSAATTQANSAHKDSQDQNKKEHVDKSQQKDKRNVTNKDKNSTVPDDIGKNGKITKRTETVYDEKTNILQNLQFDFIDDPTYDKNVLLVKKQGSIHSNLKFESHKEEKNSNWLKYPSEYHVDFQVKRNPKTEILDQLPKNKISTAKVDSTFSYSSGGKFDSTKGIGRTSSNSYSKTISYNQQNYDTIASGKNNNWHVHWSVIANDLKYGGEVKNRNDELLFYRNTRIATVENPELSFASKYRYPALVRSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDILKNRPGIHYAPPILEKNKDGQRLIVTYEVDWKNKTVKVVDKYSDDNKPYKEG
>CP022898.1|AXJ49269.1|2077057_2078074_-|putative-leukocidin-like-protein-1-precursor
MIKQLYKNITICSLAISTALTVFPATSYAKINSEIKAVSEKNLDGDTKMYTRTATTSDSQKNITQSLQFNFLTESNYDKETVFIKAKGTIGSGLRILEPNGYWNSTLRWPGSYSVSIQNVDDNNNTNVTDFAPKNQDESREVKYTYGYKTGGDFSINRGGLTGNITKESNYSETISYQQPSYRTLLDQSTSHKGVGWKVEAHLINNMGHDHTRQLTNDSDNRTKSEIFSLTRNGNLWAKDNFTPKDKMPVTVSEGFNPEFLAVMSHDKKDKGKSQFVVHYKRSMDEFKIDWNRHGFWGYWSGENHVDKKEEKLSALYEVDWKTHDVKFVKVLNDNEKK
>CP022898.1|AXJ49268.1|2075702_2076545_+|Phospholipase-C-precursor
MLQGFYVSKLGGQYKRADLIGQSSYIKNNDVVIFNEAFDNGASDKLLSNVKKEYPYQTPVLGRSQSGWDKTEGSYSSTVAEDGGVAIVSKYPIKEKIQHVFKSGCGFDNDSNKGFVYTKIEKNGKNVHVIGTHTQSEDSRCGAGHDRKIRAEQMKEISDFVKKKNIPKNETVYIGGDLNVNKGTPEFKDMLKNLNVNDVLYAGHNSTWDPQSNSIAKYNYPNGKPEHLDYIFTDKDHKQPKQLVNEVVTEKPKPWDVYAFPYYYVYNDFSDHYPIKAYSK
>CP022898.1|AXJ49267.1|2074624_2075662_+|Tyrosine-recombinase-XerC
MKTRCYDGKKWQYEFKHEGKRYRKKGFRTKREANSAGLDKLNELRSGFNIDNYITLAEYFENWIKTYKQPVVKENTYRHYRNALQHIQKHKIGKMELSKINRQVYQKFINDYSKEHAKETIRKTNGAIRSALDDALYDGLIFKNPAYKVNYKAGKPTKSEQEKFISVTEYEILKDHVRKKRTRSSLALFIMICTGCRVSGARNIKIEHINQVKNTIFIDERKTDTSPRYISIAKSDMKHIMDVISTFAISYDGYIFKEAGFIINLQAINNALKSACRVNNIPIITSHALRHTHCSYLLAKGVSIHYISKRLGHKNIAITTSVYSHLLEEKFNEEDKKTTKILESM
>CP022898.1|AXJ49266.1|2073902_2074517_-|hypothetical-protein
MTQFLGALLLTGVLGYIPYKYLTMIGLVSEKNKIINTPVLLIFSIETCLIWFYTFIIFNNVDLKNLSLLQLLTGLKANIWFLIIFVLTVLVFNPLIVKFIIWLINETRKFMNLDCISLLDKRDKLFNNNGKPVFIVIKDFENRIIEEGELKTYNSAGSDFDLLEVERQDFKVSDLPSNDELYIKHTLVDLKQQIKLDLYLMNEY
>CP022898.1|AXJ49265.1|2073780_2073906_+|hypothetical-protein
MADKNKKQEATRSNPINKSFEKPGASENLKSTLSEKAKKKD
>CP022898.1|AXJ49264.1|2073541_2073724_+|hypothetical-protein
MKIKNCKIKKETIVYEVLTSGNQPFTYELPKDLSSHNARKYLEFISQKIDGDKLTKEDSL
>CP022898.1|AXJ49274.1|2084013_2085321_+|Ktr-system-potassium-uptake-protein-B
MNKVHKPLYFYLMLFFSTTIIGALLLYLPFTGKKPISFLDALFIASSAFTVTGLSPVDIGSQFNILGEIVILLLIQIGGLGIVTVTLLTLVFLNRKISMKNRFLIMVTWNIDEPGGVIKLIKHLAIYSLVTELIGMICLCLSFIPKFGIGKGLFLSLFTSVSAFNNAGFALFKNNLIDYSSDPIVIITISILIIFGGIGHFVVIDFINCKKLSKLSLHSKLVLTTTSILIIIGAITFFLLEQFNTMQNMGLVEKIGNSFFQSVTTRTAGFNSIDIASINKSTALMLMLLMFIGGAPLSASGGIKITTFAVAFIFVLNYIRKENNVSVFNKEISDKHIKLSIVTINISFLFISIITFILSIINPNISLIKLLFEVVSAFGTVGLSMNLTTEYHGITKIIIIFVMLCGKVGLLTLLRTFIPPKSPKNYRYTKGQIYL
>CP022898.1|AXJ49275.1|2085892_2086519_-|hypothetical-protein
MTVKVISLSELLTGDKQEVKRKIPSVLNILNSFETISISGSESAHDVDLFLKNKSIAFDRQNLSRTHLVFSQFKSKQILVGYFTISNKPLVFTKRMLDKISNTLKKKLYQKGKTHSGNDNLIIQGYLIAQIGKNYSEEALATKSINGNDLLTLAYEKVLEGANIFGGSYIWIDYEDVDRLREFYRKFGFTEIKDHTSENNLKMAILKI
>CP022898.1|AXJ49276.1|2086515_2086695_-|hypothetical-protein
MATISITTDYKFTKKSAQKLIDAMEINENKSNVNKTNIKATKIKSTCEIENLLKDYRSN
>CP022898.1|AXJ49277.1|2087238_2088855_-|60-kDa-chaperonin
MVKQLKFSEDARQAMLRGVDQLANAVKVTIGPKGRNVVLDKEFTAPLITNDGVTIAKEIELEDPYENMGAKLVQEVANKTNEIAGDGTTTATVLAQAMIQEGLKNVTSGANPVGLRQGIDKAVKVTVEALHENSQKVENKNEIAQVGAISAADEEIGRYISEAMEKVGNDGVITIEESNGLNTELEVVEGMQFDRGYQSPYMVTDSDKMVAELERPYILVTDKKISSFQDILPLLEQVVQSNRPILIVADEVEGDALTNIVLNRMRGTFTAVAAKAPGFGDRRKAMLEDLAILTGAQVITDDLGLDLKDASIDMLGTASKVEVTKDNTTVVDGDGDENSIDARVSQLKSQIEETESDFDREKLQERLAKLAGGVAVIKVGAASETELKERKLRIEDALNSTRAAVEEGIVAGGGTALVNVYQKVSEIKAEGDIETGVNIVLKALTAPVRQIAENAGLEGSVIVERLKNAEPGVGFNAATNEWVNMLEAGIVDPTKVTRSALQHAASVAAMFLTTEAVVASIPEKNNDQPNMGGMPGMM
>CP022898.1|AXJ49278.1|2088930_2089215_-|10-kDa-chaperonin
MLKPIGNRVIIEKKEQEQTTKSGIVLTDSAKEKSNEGVIVAVGTGRLLNDGTRVTPEVKKGDRVVFQQYAGTEVKRDNETYLVLNEEDILAVIE
>CP022898.1|AXJ49279.1|2089389_2090133_+|CAAX-amino-terminal-protease-self--immunity
MTRLWASLLTVIIYILSQFLPLLIVTKLPFVQYSGIELTKAVIYIQLVLFLIAATTIILINLKIKNPTKLELEVKEPKKYIIPWALLGFALVMIYQMVVSIVYTQIFGTQQTSPNTERLIVIARKIPLFIFFVSIVGPLLEEYVFRKVIFGELFNAIKGNRIVAFAIATTVSSLIFALAHNDYKFIPIYFGMGVIFSLAYVWTKRLAVPIIIHMLQNGFVVIFQLLNPEALKKATEQANFIYHIFIP
>CP022898.1|AXJ49280.1|2090157_2091306_-|hypothetical-protein
MSYHWFKKMLLSTSILILSSSSLGLATHTVEAKDNLNGEKPTTNLNHNVTSPSVNSEINNNETGTPHESNQTGNEGTNSNSRDANPDSNNVKPDSNNQNPSSDSKPDPNNPNPGPNPKPDPDKPKPNPDPDPKPDPDKPKPNPNPKPDPNKPNPNPSPDPNQPGDSNHSGGSKNGGTWNPNASDGSNQGQWQPNGNQGNSQNPTGNDFVSQRFLALANGAYKYNPYILNQINQLGKEFGEVTDEDIYNIIRKQNFSGNAYLNGLQQQSNYFRFQYFNPLKSERYYRNLDEQVLALITGEIGSMPDLKKPEDKPDSKQRSFEPHEKDDFTVVKKQEDNKKSASTAYSKSWLAIVCSMMVVFSIMLFLFVKRNKKKNKNESQRR
>CP022898.1|AXJ49281.1|2091502_2092129_+|Nitroreductase-family-protein
MGLFKKDKKAMTFDNAMEERRSIYNLKDSISISDDELESMIAHAVKHVPSSFNSQSTRIVLLLNDNNNKFWDNTKAILKEVMGENRDFEPTEQKIDNFKHSYGTILFYEDQDVVSGLQEQMPNYYDNFAIWSTQTNAMHQFAIWTALATKGIGASLQHYNPLVDEITSNEFNIPKSWKLIAQMPFGDIREAAGEKTFNPVEDRFVIKK
>CP022898.1|AXJ49282.1|2092480_2093266_+|2-oxoglutaramate-amidase
MKVQIYQLPIIFGDSSKNETQITQWFEKNMNDEVDVVVLPEMWNNGYDLEHLNEKADNNLGQSFSFIKHLAEKYKVDIVAGSVSNIRNNQIFNTAFSVNKSGQLINEYDKVHLVPMLREHEFLTAGENVAEPFQLSDGTYVTQLICYDLRFPELLRYPARSGAKIAFYVAQWPMSRLQHWHSLLKARAIENNMFVIGTNSTGFDGNTEYAGHSIVINPNGDLVGELNESADILTVDLNLNEVEQQRENIPVFKSIKLDLYK
>CP022898.1|AXJ49283.1|2094179_2094797_+|Accessory-gene-regulator-protein-B
MIKDCTKSYNDSEESGVKLNYFDNKIDQFATYLQKRNNLDHIQFLQVRLGMQVLAVNIGKLIVMYTIAYILNIFLFTLITNLTFYLIRRHAHGAHAPSSFWCYVESIFLFTLLPLILVNYHINFLIMTIMTVIAIGMIIRYAPAATKKKPIPVRLIKRKRNYAIIVSLIFFIITLIIKEPFAQFMQLGIIIEAITLLPIFFVRRT

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Crispr_ID: CP022898_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022898_5

2213944-2214029

Orphan

Consensus_repeat	Method
CAACTTTAGTTGTTAGGGGCTCTTATGCA	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of CP022898_5

>merge|CP022898|5|2213944-2214029|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCATGCGCTTAGCGCAGGCGCTCCTATTTTTCAACTTTAGTTGTTAGGGGCTCTTATGCA

>CP022898|5|5|2213944-2214029|CRISPRCasFinder
CAACTTTAGTTGTTAGGGGCTCTTATGCA	TGCGCTTAGCGCAGGCGCTCCTATTTTT
CAACTTTAGTTGTTAGGGGCTCTTATGCA

Protein	Signature genes	Signature genes Name	Protein_function
CP022898.1\|AXJ49399.1\|2223418_2225551_+\|Transcriptional-regulator-MtlR	unknown	unknown	gnl\|CDD\|226234
CP022898.1\|AXJ49386.1\|2205901_2206315_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225556
CP022898.1\|AXJ49388.1\|2208816_2209047_-\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49384.1\|2204427_2205138_+\|Purine-nucleoside-phosphorylase-DeoD-type-1	unknown	unknown	gnl\|CDD\|180275
CP022898.1\|AXJ49390.1\|2210450_2211116_-\|putative-sugar-epimerase-YhfK	unknown	unknown	gnl\|CDD\|187554
CP022898.1\|AXJ49395.1\|2217420_2218278_-\|Putative-phosphatase-YwpJ	unknown	unknown	gnl\|CDD\|223635
CP022898.1\|AXJ49400.1\|2225562_2225997_+\|Mannitol-specific-phosphotransferase-enzyme-IIA-component	unknown	unknown	gnl\|CDD\|227014
CP022898.1\|AXJ49389.1\|2209077_2210016_-\|putative-mannose-6-phosphate-isomerase-GmuF	unknown	unknown	gnl\|CDD\|224399
CP022898.1\|AXJ49403.1\|2235132_2236488_-\|Phosphoglucosamine-mutase	unknown	unknown	gnl\|CDD\|237670
CP022898.1\|AXJ49394.1\|2215244_2216372_-\|SAP-domain-protein	unknown	unknown	gnl\|CDD\|366887
CP022898.1\|AXJ49393.1\|2212835_2213927_+\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49396.1\|2218345_2219128_-\|putative-ABC-transporter-ATP-binding-protein-YlmA	unknown	unknown	gnl\|CDD\|224044
CP022898.1\|AXJ49397.1\|2219359_2221165_-\|Glutamine--fructose-6-phosphate-aminotransferase-[isomerizing]	unknown	unknown	gnl\|CDD\|234729
CP022898.1\|AXJ49401.1\|2225996_2227103_+\|Mannitol-1-phosphate-5-dehydrogenase	unknown	unknown	gnl\|CDD\|235031
CP022898.1\|AXJ49385.1\|2205258_2205702_-\|General-stress-protein-20U	unknown	unknown	gnl\|CDD\|223854
CP022898.1\|AXJ49398.1\|2221845_2223384_+\|PTS-system-mannitol-specific-EIICB-component	unknown	unknown	gnl\|CDD\|225123
CP022898.1\|AXJ49387.1\|2206772_2208146_-\|EVE-domain-protein	unknown	unknown	gnl\|CDD\|376640
CP022898.1\|AXJ49402.1\|2227421_2234855_-\|Extracellular-matrix-binding-protein-ebh-precursor	unknown	unknown	gnl\|CDD\|275089
CP022898.1\|AXJ49392.1\|2211589_2212570_+\|Cadmium,-cobalt-and-zinc/H(+)-K(+)-antiporter	unknown	unknown	gnl\|CDD\|224151
CP022898.1\|AXJ49391.1\|2211267_2211588_+\|HTH-type-transcriptional-repressor-CzrA	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042

Protein	Function_ID	Function_description	E-value
CP022898.1\|AXJ49399.1\|2223418_2225551_+\|Transcriptional-regulator-MtlR	gnl\|CDD\|226234	COG3711, BglG, Transcriptional antiterminator [Transcription].	5.9991e-68
CP022898.1\|AXJ49386.1\|2205901_2206315_-\|hypothetical-protein	gnl\|CDD\|225556	COG3011, COG3011, Predicted thiol-disulfide oxidoreductase [General function prediction only].	2.52292e-44
CP022898.1\|AXJ49402.1\|2227421_2234855_-\|Extracellular-matrix-binding-protein-ebh-precursor	gnl\|CDD\|275089	TIGR04263, cell_wall_surface_anchor_family_protein, SasC/Mrp/FmtB intercellular aggregation domain. This domain, about 375 amino acids long on average, occurs only in Staphylococcus and Streptococcus. It occurs as a non-repetitive N-terminal domain of LPXTG-anchored surface proteins, including SasC, Mrp, and FmtB. This region in SasC was shown to be involved in cell aggregation and biofilm formation, which may explain the methicillin resistance seen for Mrp and FmtB.	1.37143e-108
CP022898.1\|AXJ49384.1\|2204427_2205138_+\|Purine-nucleoside-phosphorylase-DeoD-type-1	gnl\|CDD\|180275	PRK05819, deoD, DeoD-type purine-nucleoside phosphorylase.	2.10672e-157
CP022898.1\|AXJ49390.1\|2210450_2211116_-\|putative-sugar-epimerase-YhfK	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	8.86209e-48
CP022898.1\|AXJ49395.1\|2217420_2218278_-\|Putative-phosphatase-YwpJ	gnl\|CDD\|223635	COG0561, Cof, Predicted hydrolases of the HAD superfamily [General function prediction only].	2.43638e-59
CP022898.1\|AXJ49400.1\|2225562_2225997_+\|Mannitol-specific-phosphotransferase-enzyme-IIA-component	gnl\|CDD\|227014	COG4668, MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism].	2.08822e-62
CP022898.1\|AXJ49389.1\|2209077_2210016_-\|putative-mannose-6-phosphate-isomerase-GmuF	gnl\|CDD\|224399	COG1482, ManA, Phosphomannose isomerase [Carbohydrate transport and metabolism].	1.46752e-128
CP022898.1\|AXJ49403.1\|2235132_2236488_-\|Phosphoglucosamine-mutase	gnl\|CDD\|237670	PRK14316, glmM, phosphoglucosamine mutase; Provisional.	0
CP022898.1\|AXJ49394.1\|2215244_2216372_-\|SAP-domain-protein	gnl\|CDD\|366887	pfam02037, SAP, SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.	5.97077e-06
CP022898.1\|AXJ49387.1\|2206772_2208146_-\|EVE-domain-protein	gnl\|CDD\|376640	pfam01878, EVE, EVE domain. This domain was formerly known as DUF55. Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding.	3.92966e-06
CP022898.1\|AXJ49396.1\|2218345_2219128_-\|putative-ABC-transporter-ATP-binding-protein-YlmA	gnl\|CDD\|224044	COG1119, ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism].	1.56485e-106
CP022898.1\|AXJ49397.1\|2219359_2221165_-\|Glutamine--fructose-6-phosphate-aminotransferase-[isomerizing]	gnl\|CDD\|234729	PRK00331, PRK00331, isomerizing glutamine--fructose-6-phosphate transaminase.	0
CP022898.1\|AXJ49401.1\|2225996_2227103_+\|Mannitol-1-phosphate-5-dehydrogenase	gnl\|CDD\|235031	PRK02318, PRK02318, mannitol-1-phosphate 5-dehydrogenase; Provisional.	0
CP022898.1\|AXJ49385.1\|2205258_2205702_-\|General-stress-protein-20U	gnl\|CDD\|223854	COG0783, Dps, DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism].	5.87929e-68
CP022898.1\|AXJ49398.1\|2221845_2223384_+\|PTS-system-mannitol-specific-EIICB-component	gnl\|CDD\|225123	COG2213, MtlA, Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism].	0
CP022898.1\|AXJ49392.1\|2211589_2212570_+\|Cadmium,-cobalt-and-zinc/H(+)-K(+)-antiporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	8.62765e-109
CP022898.1\|AXJ49391.1\|2211267_2211588_+\|HTH-type-transcriptional-repressor-CzrA	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.8473e-17

>CP022898.1|AXJ49393.1|2212835_2213927_+|hypothetical-protein
MFTYFKSALKNAKPQLLITLIYALIAFAVIAVVYLLANFQLAKYVQNIVIYSQFGQKPPGDVYLKVIAVLLIAAIVSLFVLVQIFIGITNVMKRAMSHEKVKFTDLFIAFKKGIYLKSVLIGLVSIAMIIVLSLLTSLLYKLFSPVSEMIMNSVQSSYADSTHLIGIAITTQSIIIIVVLLIKAIITWLLLIPIFNFMTSFVESTNDKVKTHLANGFKAMKNGQKTFFKFFIGILLLNLIIILFKTPVGYLISFNTQSLSQSVAENIIRVYTVMTIILFVVIHAIILMGIVQYYLKRGQKITKDKVKTADKDNKVVTEPKNTKVETDKVTTSVETKTEKAQDSLNDNTTKTMTSDKPEDNQPK
>CP022898.1|AXJ49392.1|2211589_2212570_+|Cadmium,-cobalt-and-zinc/H(+)-K(+)-antiporter
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNATATKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSVHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESIICSGTHSHSHNHHAHHHAHVH
>CP022898.1|AXJ49391.1|2211267_2211588_+|HTH-type-transcriptional-repressor-CzrA
MSEQYSEINTDTLERVTEIFKALGDYNRIRIMELLSVSEASVGHISHQLNLSQSNVSHQLKLLKSVHLVKAKRQGQSMIYSLDDIHVATMLKQAIHHANHPKESGL
>CP022898.1|AXJ49390.1|2210450_2211116_-|putative-sugar-epimerase-YhfK
MNILVIGANGGVGSLLVQQLAKENVPFTAGVRQSDQLNALKSQGMKAILVDVENDSIETLTETFKPFDKVIFSVGSGGNTGADKTIIVDLDGAVKSIIASKEANIKHYVMVSTYDSRRQAFDDSGDLKPYTIAKHYADDYLRRSGLNYTILHPGALTNAAGSGKIEAAQYFEGKGEIPREDVATVLKEIVTSNHFNHQEFQVISGEQDIKDALTQFENETD
>CP022898.1|AXJ49389.1|2209077_2210016_-|putative-mannose-6-phosphate-isomerase-GmuF
MPLFLQPILKTKLWGGQRLSEFGYQLDNDTTGECWCVSAHPNGKSEIINGPYQGQTLDRIWSEHRELFGDFPSKDFPLLTKIVDARESLSIHVHPDNSYAYEHENGQYGKSECWYIIDAEEDAEIVIGTLAESREEVANHVQRGTIESILRYIKVKPGEFYFIPAGTVHTISSGILAYETMQSSDITYRLYDFNRQDNQYNDRPLNIEKALDVIQYNAPLPNILPESEIIENHKCTHIVSNDFFTLVKWEISGTLNYMKPREFCLVTVLEGEGQMIVDGEIFKLTTGTNFILTSEDLDSVFEGDFTLMISYA
>CP022898.1|AXJ49388.1|2208816_2209047_-|hypothetical-protein
MKQFLYIALVCSVIAGLGAFLHIPQYPSMTIPRIVAILGIISAMLTFKDKQISASLKFSALLINVLPLCGTFVASN
>CP022898.1|AXJ49387.1|2206772_2208146_-|EVE-domain-protein
MTAETNYFWLNCGYNRWNHNEPLVGQTALFESGAHFNPSQGFRAFKKAKVGDQVIFYQVQTDTGLLGCGEIISVETGAQNKIRVQFRFNEQLKPLTADYLKRSEALEFRMSNMKETLFNQINAEEFDLISGLGKGEIKIPRYFFLAETEEFEPGNQYTIYTHTYNGIKRNGYHFYTQLEEGDNIIFYNRTKNQSVVGIGEVSKHIHEKPPIPGRTNSTVIEVSYEKDITPITLSTLNKHPKLKNLYFLQENAKQAIASMSQAQYDAIIEMSDNNGLKSPFEMVQKPDMLESEKEEALKPFILLVVDRKEEGLKAANDLLQKANANPVITTGHPDFSEDMLYGKYLPNETGALYYREGFITQLMPKKDKSYLVIDNFNRIDTDIFQTYINVLEGYEVTLPRYNKDGNMIKWSRQKDSFYYFNPNWHIVGITYDSLEEIKEKYSEQFLKYTRIVKVKHD
>CP022898.1|AXJ49386.1|2205901_2206315_-|hypothetical-protein
MPIVYYDGNCIYCYNYVIWLIQHDLPRNYQFATLKGEVGQQFFKQHPEAANKNSVILQKGDRIYFESQAIIQLITSLPNRTKLLGIGLWLVPKPVRNFGYRMFANNRNRMWKTTWHQPNDYEKSFFLDDNAKVKLTD
>CP022898.1|AXJ49385.1|2205258_2205702_-|General-stress-protein-20U
MSNQQDVVKELNQQVANWTVAYTKLHNFHWYVKGPNFFSLHVKFEELYNEASQYVDELAERILAVGGNPVGTLTECLEQSIVKEAAKGYSAEQMVEELSQDFTNISKQLEKAIEIAGNAGDDVSEDMFIGMQTSVDKHNWMFKSYLS
>CP022898.1|AXJ49384.1|2204427_2205138_+|Purine-nucleoside-phosphorylase-DeoD-type-1
MTKGTPHIQPNGVKIAKTVLMPGDPLRAKYIADNFLENVEQFNDVRNMFGYTGTYKGKEVSVMGSGMGIPSIGIYSYELYNFFDVDTIIRIGSCGALQENVNLYDVIIAQAASTNSNYVDQYNIPGHFAPIADFELVTKAKNVADQIGATTHVGNVLSSDTFYNADPTFNDAWKKMGILGIEMESAGLYLNAIHAGKKALGIFTVSDHILRDEATTPEERQNSFTQMMEIALEIAE
>CP022898.1|AXJ49394.1|2215244_2216372_-|SAP-domain-protein
MSVNARDLLVLHNNVNRLVGEEIFANKCLANNDVQIMNSIKKLIEAELLTTTNDFEVSIYKKTRPELQSILKSFGIKTTGNKPDLIKRIDDNFHIINNLDLPYVYIPTKKGEEILKKTEYLTSFIYSYKISLERAYYMVENYIDENCDDKVAEIYKFEFQRKYDNGEFDFNHGYNFELNMLIDHYKRDVKDYDNARKYSNFYLYFGLRDFLKKLMSNYSYYDSKGNIDLNEIQNDLNRFINSSASGMYERLIYNENLSNNIMFELFKKDTQDYSDLEEQLIEKFINYVVSYVKKESRSNTLIELSKMLEKGYTIDKEKFKKEDEYLSRYIITDINYLKNLESKIGVAIDSRNGEIHLVLDDDSLDKLIKNQKNRQ
>CP022898.1|AXJ49395.1|2217420_2218278_-|Putative-phosphatase-YwpJ
MDNVKAIFLDMDGTILHENNQASTYTKDVINRLREKGYKVFLATGRSHSEIHQLVPEDFAVNGIISSNGTIGEVDGEIIFKHGLSLAQVQQIINLAKRQQIYYEVFPFEGNRVSLKEDETWMRDMIRSQDPINGVSHSEWSSRQDALAGKIDWVTKFPEGEYSKIYLFSSNLEKITAFRDELKQNHVQLQISVSNSSRFNAETMAYQTDKGTGIKEMIAHFGIHQEETLVIGDSDNDRAMFEFGHYTVAMKNARPEIQALTSDVTAYTNEEDGAAKYLAKHFLAD
>CP022898.1|AXJ49396.1|2218345_2219128_-|putative-ABC-transporter-ATP-binding-protein-YlmA
MLIQLDQVGRMKQGKTILKNISWQINGGDKWILYGLNGAGKTTLLNILNVYEPPTTGDVNLFGKMPGKVGYSAETVRQHIGFVSHSLLEKFQEGERVIDVVISGAFKSIGVYQDIDDEIRNEAHQLLKLVGMSAKAQQYIGYLSTGEKQRVMIARALMGQPQVLILDEPAAGLDFIARESLLSILDSLSDSYPTLAMIYVTHFIEEITGNFTKILLLKDGESVQQGLIDDILTSENMSRFFQKNVAVQRWNNRFSMAMLE
>CP022898.1|AXJ49397.1|2219359_2221165_-|Glutamine--fructose-6-phosphate-aminotransferase-[isomerizing]
MCGIVGYIGYDNAKELLLKGLEKLEYRGYDSAGIAVVNDDNTTVFKEKGRIAELRKVADSSDFDGPVGIGHTRWATHGVPNHENSHPHQSSNGRFTLVHNGVIENYEELKSEYLQGVSFISETDTEVIVQLVEYFSNQGLSTEEAFTKVVSLLHGSYALGLLDAEDKDTIYVAKNKSPLLLGVGEGFNVIASDALAMLQVTSEYKEIHDHEIVIVKKDEVIIKDADGNVVERDSYIAEIDASDAEKGVYAHYMLKEIHEQPAVMRRIIQEYQDAEGNLKIDQDIINDVKEADRIYVIAAGTSYHAGLVGKEFLEKWAGVPTEVHVASEFVYNMPLLSEKPLFVYISQSGETADSRAVLVETNKLGHKSLTITNVAGSTLSREADHTLLLHAGPEIAVASTKAYTAQIAVLSILSQIVAKEHGREADIDLLRELAKVTTAIEAIVDDAPIMEQIATDFLETTRNAFFIGRTIDYNVSLEGALKLKEISYIQAEGFAGGELKHGTIALIEEGTPVVGLATQEKVNLSIRGNVKEVVARGAHPCIISMEGLEKEGDTYVIPHVHELLTPLVSVVALQLISYYAALHRDLDVDKPRNLAKSVTVE
>CP022898.1|AXJ49398.1|2221845_2223384_+|PTS-system-mannitol-specific-EIICB-component
MSQTEEKKGIGRRVQAFGSFLSSMIMPNIGAFIAWGFIAAIFIDNGWLPNKDLATLAGPMITYLIPLLIAFSGGRLIYDLRGGIIAATATMGVIVALPDTPMLLGAMIMGPLVGWLMKKTDQLIQPRTPQGFEMLFNNFSAGILGFIMTIVGFKVLAPIMKFIMYILSVAVESLVHAHLLPVVSILVEPAKILFLNNAINHGVFTPLGTDQAAKVGQSILYTIESNPGPGLGILLAYMIFGKGTAKATSYGAGIIHFLGGIHEIYFPYVLMRPLLFIAVILGGMTGVATYQATGFGFKTPASPGSFIVYCLNAPRGEFLHMLLGVFLAALVSFVVAALIMKFTREPKQDLEAATAQMENTKGKKSSVASKLVSSDKNVNTEENASGNVSETSSSDDDPEALLDNYNTEDVDAHNYNNINHVIFACDAGMGSSAMGASMLRNKFKKAGINDITVTNTAINQLPKDAQLVITQKKLTDRAIKQTPNAIHISVDNFLNSPRYEELLNNLKKDDQA
>CP022898.1|AXJ49399.1|2223418_2225551_+|Transcriptional-regulator-MtlR
MLLSTREKEMIALLIKYHGQYITIHDIAQQLAVSSRTIHRELKGVEAYLTSFSLTLERANKKGLRIAGEDSDLNDLKQSIAQHQTIDLSVEEQKVIIIYALIQAKEPVKQYSLAQEIGVSVQTLAKMLDDLELDLNKYQLSLSRKRGEGIYLVGTESKKREFLSQLMVNNLNSTSVYSVIENHFVFHSLNQIHKDFVDLERIFNVERLLMDYLSALPYQLTESSYLTLTVHIVLSISRIKNGEYVALNDDIYDSVQNTFEHKVASELADKLGQIYDVTFNQAEIAFITIHLRGAKRKNLNDTSLNNRCEENKIKAFVKKVEMISGMTFADLDTLVDGLTLHLNPAINRLQANIETYNPLTDMIKFKYPRLFENVRLALNDCWPDLIFPESEIAFIVLHFGGSIKNQGNRFLNILVVCSSGMGTSRLLSTRLEQVFSEIERITQASVSDLKSLDLSQYDGIISTVNLDIDSPYLTVNPLLPDSDISYVAQFLNTKSTFQETHDKSSNMIDKDDVHIETKDIDGNTSFENEQTSNLTSVFEKHLSDEKSEQLMHHMRSGLTLLDSVKIVSTEVKQWQTYIADYLYQCDVINDPTSFAELLEQRLIDNPGWILSPYPVAIPHLRDNMIKHPMILITVLEEPLALPSIQNDNQTIKYMISMFIPDNDFMASLVSDLSEFLSLKLESIDTFMENPQELETLLRNKFLERIKKQFI
>CP022898.1|AXJ49400.1|2225562_2225997_+|Mannitol-specific-phosphotransferase-enzyme-IIA-component
MSELFSNDNIFLNVNVNSQNEAIEKAGKALVDSGAVTDAYIQAMKDREQVVSTFMGNGLAIPHGTDEAKTNVIHSGLTLLQIPEGVDWDGEVVKVVVGIAGKDGEHLDLLSKIAITFSEEENVDRIVQAKSAEEIKQVFEEADA
>CP022898.1|AXJ49401.1|2225996_2227103_+|Mannitol-1-phosphate-5-dehydrogenase
MKAVHFGAGNIGRGFIGYILADNNVKVTFADVNEEIINALAHDHQYDVILADESKTTTRVNNVDAINSMQPSEALKQAILEADIITTAVGVNILPIIAKSFAPFLKEKTNHVNIVACENAIMATDTLKKAVLDITGPLGNNIHFANSAVDRIVPLQKNENILDVMVEPFYEWVVEKDAWYGPELNHIKYVDDLTPYIERKLLTVNTGHAYLAYAGKFADKATVLDAVKDSSIEAGLRRVLAETSQYITNEFDFTEAEQAGYVEKIIDRFNNSYLSDEVTRVGRGTLRKIGPKDRIIKPLTYLYNKDLERTGLLNTAALLLKYDDTADQETVEKNNYIKEHGLKVFLSEYAKVDDGLADEIIEAYNSLS
>CP022898.1|AXJ49402.1|2227421_2234855_-|Extracellular-matrix-binding-protein-ebh-precursor
MNLFRQQKFSIRKFNVGIFSALIATVTFISTNPTTASAAEQNQPAQNQPAQPADANTQPNANAGAQANPTAQPAAPANQGQPAAQPANQGGQANPAGGAAQPNTQPAGQGNQADPNNAAQAQPGNQAAPANQAGQGNNQATPNNNATPANQTQPANAPAAAQPAANAQTQDPNASNTGEGSINTTLTFDDPAISTDENRQDPTVTVTDKVNGYSLINNGKIGFVNSELRRSDMFDKNNPQNYQARGNVAALGRVNANDSTDHGNFNGISKTVNVKPDSELIINFTTMQTNSKQGATNLVIKDAKKNTELATVNVAKTGTAHLFKVPTDADRLDLQFIPDNTAVADASRITTNKDGYKYYSFIDNVGLFSGSHLYVKNRDLAPKATNNKEFTINTEIGNNGNFGASLKADQFKYEVTLPQGVTYVNDSLTTTFPNGNEDSTVLKNMTVNYDQNANKVTFTSQGVTTARGTHTKEVLFPDKSLKLSYKVNVANIDTPKNIDFNEKLTYRTASDVVINNAQPEVTLTADPFSVAVEMNKDALQQQVNSQVDNSHYTTASIAEYNKLKQQADNILNEDANHVETANRASQAAIDGLVTKLQAALIDNQAAIAELDAKAQEKVTAAQQSKKVTQDEVAALVTKINNDKNNAIAEINKQTTSQGVTTEKDNGIAVLEQDVITPTVKPQAKQDIIQAVTTRKQQIKKSNASLQDEKDVANDKIGKIETKAIKDIDAATTNAQVEAIKTKAINDINQTAPATTAKAAALEEFDEVVQAQIDQAPLNPDTTNEEVAEAIERINAAKVSDVKAIEATTTAQDLERVKNEEISKIENITDSTQTKMDAYNDVKQAATARKAQNATVSNATNEEVAEADAAVEAAQKQGLHDIQVVKSKQEVADTKSKVLDKINAIQTQAKVKPAADTEVENAYNTRKQEIQNSNASTTEEKQAAYTELDTKKQEARTNLDAANTNSDVTTAKDNSIAAINQVQAATTKKSDAKAEIAQKASERKTAIEAMNDSTTEEQQAAKDKVDQAVVTANTDIDNAAANTDVDNAKTTNEATIAAITPDANVKPTAKQAIADKVQAQETAIDAYNGATTEEKAAAKQQVQTEKTTADAAIDGAHSNAEVEAAKNAEIAKIEAIQPATTTKDDAKQAITTKANERKAAIAQTQDITAEEIAAANADVDNAVTQANSNIEAANSQNDVDQAKTTGETSIDQVTPTVNKKATARNEITTILNNKLQAIQATPDATDEEKQAADAEANTENGKANQAISAATTNAQVDEAKANAEVAINAVTPKVVKKQAAKDEIDQLQVAQTSVINNDQNATNEEKEAAIQQLATAVTDAKNNITAATDDNGVDQAKDAGKNSIQSTQPATAVKSNAKNEVDQAVTTQNQAIDNTTGATTEEKNAAKDLVLKAKEKAYQDILNAQTTNDVTQIKDQAVADVQGITADTTIKDVAKDELATKANEQKALIAQTADATTEEKEQANQQVDAQLTQGNQNIENAQSIDDVNTAKDNAIQAIDPIQASTDVKTNARAELLTEMQNKITEILSDNTTTNEEKGKDIEPVRATYEEGLNNINTANTTGDVTTAKDTAVQKVQQLHANPVKKPAGKTALDQAAADRKTQIEQTPNASQQEINDAKQEVDATLNQAKTNVDQSSTNEYVDNAVKEGKAKINAVKTFSEYKKDALAKIEAAYNSKVNEADNSNASTSSEIAEAKQKLAELKQTADQNVNQATSKDDIEVQIHNDLDNINDYTIPTGKKETATTDLYAYADQKKNNISADTNATQDEKQQAIKQVDQNVQTALESINNGVDNGDVDDALTQGKAAIDAIQVDATVKPKANQAIEAKAEDTKESIDHSDQLTAEEKTEALAMIKQITDQAKKGINDATTTAEVEKAKAQGLEAFDNIQIDSTEKQKAIEELETALDQIEAGVNVDADATTEEKEAFTNALEDILSKATEDISDQTTNAEIATVKNSALEQLKAQRINPEVKKNALEAIREVVNKQIEIIKNADASAKEIARTDLGRYFDRFADNLDKTQTNAEVAELQNVTIPAIEAIVPQNDPDANDTNNGTDNNDATANSNANATPENTGQPNVSETTDNGKADASPTTPNNSDAATGETTATSTNNPSTDDANNKPTANNNSSVDASTDNSATGNGTIDKPEVESTNNGTTDKPATETDNVTPAESTTNNNSTTATNENAPTGSTATAPTTASTEAASSADSKDNAFVNDSKQNAEVNNSAESQSTNGMVVQPKSENKAKAEKDGRDSTNQSMVESTTETLPSADITEPKVPSNTSKDKEESTTNQTDAGHLKSETNVASNEVDKSEGNVDTDVSNKPSTSKPSEAKDKATSTEDSQKADMATADTKDNQAAIGATADVNNKATQNDGANASPATVSNGSNSTNQDMLNVTKTEENKANVKSAQQGKVNKPKQQAKTLPDTGMSHNDDLPYAELALGAGMAFLIRRFTKKDQQTEE
>CP022898.1|AXJ49403.1|2235132_2236488_-|Phosphoglucosamine-mutase
MGKYFGTDGVRGVANQELTPELAFKLGRYGGYVLAHNKGEKHPRVLVGRDTRVSGEMLESALIAGLISIGAEVMRLGIISTPGVAYLTRDMGAELGVMISASHNPVADNGIKFFGSDGFKLSDEQENEIEALLDQENPELPRPVGNDIVHYSDYFEGAQKYLSYLKSTVDVNFEGLKIVLDGANGSTSSLAPFLFGDLEADTETIGCSPDGYNINEKCGSTHPEKLAEKVVETESDFGLAFDGDGDRIIAVDENGQIVDGDQIMFIIGQEMHKNQELNNDMIVSTVMSNLGFYKALEQEGIKSNKTKVGDRYVVEEMRRGNYNLGGEQSGHIVMMDYNTTGDGLLTGIQLASVIKMTGKSLSELAGQMKKYPQSLINVRVTDKYRVEENVDVKEVMTKVEVEMNGEGRILVRPSGTEPLVRVMVEAATDEDAERFAQQIADVVQDKMGLDK

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Crispr_ID: CP022898_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022898_6

2331311-2331399

Orphan

Consensus_repeat	Method
GTTCCCCAACTTGCACATTATTGTATGCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022898_6

>merge|CP022898|6|2331311-2331399|CRISPRCasFinder
GTTCCCCAACTTGCACATTATTGTATGCTGACTTTTGTCAGCTTCTGTGTTGGGGCCCCGTTCCCCAACTTGCACATTATTGTAAGCTG

>CP022898|6|6|2331311-2331399|CRISPRCasFinder
GTTCCCCAACTTGCACATTATTGTATGCTG	ACTTTTGTCAGCTTCTGTGTTGGGGCCCC
GTTCCCCAACTTGCACATTATTGTAAGCTG

Protein	Signature genes	Signature genes Name	Protein_function
CP022898.1\|AXJ49501.1\|2330649_2331000_-\|HTH-type-transcriptional-regulator-SarV	unknown	unknown	gnl\|CDD\|130944
CP022898.1\|AXJ49507.1\|2334410_2335670_-\|Molybdopterin-molybdenumtransferase	unknown	unknown	gnl\|CDD\|238452
CP022898.1\|AXJ49504.1\|2333229_2333463_-\|Molybdopterin-synthase-sulfur-carrier-subunit	unknown	unknown	gnl\|CDD\|340452
CP022898.1\|AXJ49495.1\|2322794_2325962_-\|Swarming-motility-protein-SwrC	unknown	unknown	gnl\|CDD\|223911
CP022898.1\|AXJ49505.1\|2333468_2333915_-\|Molybdopterin-synthase-catalytic-subunit	unknown	unknown	gnl\|CDD\|223391
CP022898.1\|AXJ49509.1\|2336228_2336735_-\|Molybdenum-cofactor-biosynthesis-protein-B	unknown	unknown	gnl\|CDD\|223595
CP022898.1\|AXJ49508.1\|2335732_2336227_+\|Cyclic-pyranopterin-monophosphate-synthase-accessory-protein	unknown	unknown	gnl\|CDD\|236483
CP022898.1\|AXJ49494.1\|2322290_2322608_+\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49503.1\|2332623_2333223_-\|putative-molybdenum-cofactor-guanylyltransferase	unknown	unknown	gnl\|CDD\|234725
CP022898.1\|AXJ49497.1\|2327732_2327984_+\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49496.1\|2326078_2327344_-\|Lipid-II:glycine-glycyltransferase	unknown	unknown	gnl\|CDD\|225224
CP022898.1\|AXJ49493.1\|2321891_2322056_+\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49510.1\|2336765_2337770_-\|Molybdopterin-synthase-adenylyltransferase	unknown	unknown	gnl\|CDD\|181084
CP022898.1\|AXJ49498.1\|2327975_2328740_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379203
CP022898.1\|AXJ49499.1\|2328903_2329344_+\|putative-HTH-type-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
CP022898.1\|AXJ49511.1\|2337938_2338544_-\|Sulfate/thiosulfate-import-ATP-binding-protein-CysA	unknown	unknown	gnl\|CDD\|226628
CP022898.1\|AXJ49500.1\|2329336_2330548_+\|major-facilitator-superfamily-transporter	unknown	unknown	gnl\|CDD\|341042
CP022898.1\|AXJ49502.1\|2331581_2332604_-\|Cyclic-pyranopterin-monophosphate-synthase	unknown	unknown	gnl\|CDD\|274250
CP022898.1\|AXJ49492.1\|2320850_2321759_-\|Membrane-transport-protein	unknown	unknown	gnl\|CDD\|223751
CP022898.1\|AXJ49506.1\|2333928_2334414_-\|Molybdopterin-guanine-dinucleotide-biosynthesis-adapter-protein	unknown	unknown	gnl\|CDD\|224677

Protein	Function_ID	Function_description	E-value
CP022898.1\|AXJ49496.1\|2326078_2327344_-\|Lipid-II:glycine-glycyltransferase	gnl\|CDD\|225224	COG2348, COG2348, Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis].	8.95714e-143
CP022898.1\|AXJ49507.1\|2334410_2335670_-\|Molybdopterin-molybdenumtransferase	gnl\|CDD\|238452	cd00887, MoeA, MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.	9.192e-158
CP022898.1\|AXJ49504.1\|2333229_2333463_-\|Molybdopterin-synthase-sulfur-carrier-subunit	gnl\|CDD\|340452	cd00754, Ubl_MoaD, ubiquitin-like (Ubl) domain found in molybdenum cofactor biosynthesis protein D (MoaD) and similar proteins. MoaD, also termed molybdopterin synthase sulfur carrier subunit, or MPT synthase subunit 1, or MPT synthase small subunit, or molybdopterin-converting factor small subunit, or molybdopterin-converting factor subunit 1, is a conserved small sulfur carrier protein that has beta-grasp ubiquitin-like (Ubl) fold involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor of a diverse group of redox enzymes. MoaD is activated in an ATP-dependent manner by sulfurtransferases similar to the activation mechanism of ubiquitin-activating enzyme E1.	5.99629e-25
CP022898.1\|AXJ49495.1\|2322794_2325962_-\|Swarming-motility-protein-SwrC	gnl\|CDD\|223911	COG0841, AcrB, Cation/multidrug efflux pump [Defense mechanisms].	0
CP022898.1\|AXJ49505.1\|2333468_2333915_-\|Molybdopterin-synthase-catalytic-subunit	gnl\|CDD\|223391	COG0314, MoaE, Molybdopterin converting factor, large subunit [Coenzyme metabolism].	5.56799e-58
CP022898.1\|AXJ49509.1\|2336228_2336735_-\|Molybdenum-cofactor-biosynthesis-protein-B	gnl\|CDD\|223595	COG0521, MoaB, Molybdopterin biosynthesis enzymes [Coenzyme metabolism].	1.92933e-64
CP022898.1\|AXJ49508.1\|2335732_2336227_+\|Cyclic-pyranopterin-monophosphate-synthase-accessory-protein	gnl\|CDD\|236483	PRK09364, moaC, cyclic pyranopterin monophosphate synthase MoaC.	2.70933e-97
CP022898.1\|AXJ49503.1\|2332623_2333223_-\|putative-molybdenum-cofactor-guanylyltransferase	gnl\|CDD\|234725	PRK00317, mobA, molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed.	5.68918e-67
CP022898.1\|AXJ49501.1\|2330649_2331000_-\|HTH-type-transcriptional-regulator-SarV	gnl\|CDD\|130944	TIGR01889, Pleiotropic_Regulator_Of_Virulence, staphylococcal accessory regulator family. This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions].	2.64009e-20
CP022898.1\|AXJ49510.1\|2336765_2337770_-\|Molybdopterin-synthase-adenylyltransferase	gnl\|CDD\|181084	PRK07688, PRK07688, thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated.	1.97922e-131
CP022898.1\|AXJ49498.1\|2327975_2328740_-\|hypothetical-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	1.50083e-38
CP022898.1\|AXJ49499.1\|2328903_2329344_+\|putative-HTH-type-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.06862e-14
CP022898.1\|AXJ49511.1\|2337938_2338544_-\|Sulfate/thiosulfate-import-ATP-binding-protein-CysA	gnl\|CDD\|226628	COG4148, ModC, ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism].	1.84496e-113
CP022898.1\|AXJ49500.1\|2329336_2330548_+\|major-facilitator-superfamily-transporter	gnl\|CDD\|341042	cd17489, MFS_YfcJ_like, Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.81635e-72
CP022898.1\|AXJ49502.1\|2331581_2332604_-\|Cyclic-pyranopterin-monophosphate-synthase	gnl\|CDD\|274250	TIGR02666, Cyclic_pyranopterin_monophosphate_synthase, molybdenum cofactor biosynthesis protein A, bacterial. The model for this family describes molybdenum cofactor biosynthesis protein A, or MoaA, as found in bacteria. It does not include the family of probable functional equivalent proteins from the archaea. MoaA works together with MoaC to synthesize precursor Z from guanine. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin].	1.0538e-165
CP022898.1\|AXJ49492.1\|2320850_2321759_-\|Membrane-transport-protein	gnl\|CDD\|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	3.9513e-43
CP022898.1\|AXJ49506.1\|2333928_2334414_-\|Molybdopterin-guanine-dinucleotide-biosynthesis-adapter-protein	gnl\|CDD\|224677	COG1763, MobB, Molybdopterin-guanine dinucleotide biosynthesis protein [Coenzyme metabolism].	1.7369e-49

>CP022898.1|AXJ49501.1|2330649_2331000_-|HTH-type-transcriptional-regulator-SarV
MSNKVQRFIEAERELSQLKHWLKTTHKISIEEFVVLFKVYEAEKISGKELRDTLHFEMLWDTSKIDVIIRKIYKKELISKLRSETDERQVFYFYSTSQKKLLDKITKEIEVLSVTN
>CP022898.1|AXJ49500.1|2329336_2330548_+|major-facilitator-superfamily-transporter
MTNQGSLNKSPIFTKSFTINFLVNFIVYLCMYLLLVVIAGYSKQAFDASDSLAGLVVGLFIVGSLIGRFATGKFVNQIGPKRLLFIGLIALIITQLLYFIDGSLAFLIFVRLINGIATAVVTTATGTIAAYVTPVNRKSEGISLFSLSLVLGTAIGPFLGMLLITKYAIDLLFIICVILGILGLIISLFIKVDFEVTNNKTETNVIDKPSFSIHQFIAKEAIPVAVIMLLIGVTYASILTYLQAFALERHLVTAASYFFICYAIASLITRPIAGRLMDDKNENIIVYPAFIMLFLSFVCLISSYQSWLILLAGACLGLGYGNLSSAMQSIAIKVSPPIKYGIATSTFYVGLDAGVGFGPSFLGLFTHMFSYSEIFGFMAALAIITMLVYFLIHGRHVTRNAMN
>CP022898.1|AXJ49499.1|2328903_2329344_+|putative-HTH-type-transcriptional-regulator
MLSQEFFNSFITIYRPYLKLAEPILEKHNIYYGQWLILRDIAKYQPTTLIEISHRRAIEKPTARKTLKALIENDLITVENSLEDKRQKFLTLTPKGHELYEIVCLDVQKLQQAVVAKTNISQDQMQETINVMNQIHEILLKEAHND
>CP022898.1|AXJ49498.1|2327975_2328740_-|hypothetical-protein
MILKFDHIIHYIDQLDRFSFPGDVIKLHSGGYHHKYGTFNKLGYINENYIELLDVENNEKLKKMAKTIEGGVAFATQIVQEKYEQGFKNICLRTNDIEAVKNKLQSEQVEVVGPIQMERDTHKDGKVKWQLLYIMNQDDDEIKPPFFIQWEESDSMRTKKLQKYFQKQFSIETVIVKSKNRSQTVSNWLKWFDMDIVEENDHYTDLILKNDDIYFRIEDGKVSKYHSVIIKDAQATSPYSIFIRGAIYRFEPLV
>CP022898.1|AXJ49497.1|2327732_2327984_+|hypothetical-protein
MRTIILSLFIIMNIVAIIMTLSQPLTVNYFSLRVILIFFTFILSIFFILIKSSRLNNILTILSIVLAIIHMGILAHSTYVYLY
>CP022898.1|AXJ49496.1|2326078_2327344_-|Lipid-II:glycine-glycyltransferase
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEIQGVAQLLFKKVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIAKVNQELNELHAEIAKWQQKMETSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKRK
>CP022898.1|AXJ49495.1|2322794_2325962_-|Swarming-motility-protein-SwrC
MIKKLLQFSLGNKFAIFLMVVLVVLGGVYASAKLKLELLPNVQNPVISVTTTMPGATPQSTQDEISSKIDNQVRSLAYVKNVKTQSIQNASIVTVEYENNTDMDKAEEQLKKEIDKIKFKDEVGQPELRRNSMDAFPVLAYSFSNKENDLKKVTKVLNEQLIPKLQTVDGVQNAQLNGQTNREITLKFKQNELEKYGLTADDVENYLKTATRTTPLGLFQFGDKDKSIVVDGQYQSVDAFKNINIPLTLAGGQGQSQSQSDNKQNSAMSDVNQASPQQNSKASASNNISGMPTAKLGDLADITVGDVRTSISKTNGKDAVNLQITKAQDANTVQVAKDVQRKIDTFVDENKDFNVTKTMDTAKPVEKSLYTMIEKASLGTIVAIIVILLFLRNIRTTAISIISIPLSLLMALIALKLSDVSLNILTLGALTVAIGRVIDDSIVVVENIYRRLTDSEEQLKGENLIISATTEVFKPIMSSTLVTIIVFLPLVFVSGSVGEMFRPFALAIAFSLLASLLVSITLVPALAATLFKKGVKRRNKQHQEGLGVVSTTYKKVLHWSLNHKWIVIILSTLILLATIVFGGPRLGTSFISAGDDKFLAITYTPKPGETEQAVLNHAKDVEKYLKQKKHVKTIQYSVGGSSPVDPTGSTNSMAIMVEYDNDTPNFDVEADKVIKHADGFKHPGEWKNQDLGTGAGNKSVEVTVKGPSMDAIKSTVKDIEQKMKQVKGLANVKSDLSQTYDQYEIKVDQNKAAENGISASQLAMHLNENLPEKTVTTVKENGKTVDVKVKQNKQTDWSEDKLNNITLKKPTGGTIKLGDIATLVKTTTPSKLTQEQGDYATTVSAKVTNKDVGGTTRQVMSKINNLDKPNNVKVNIGGASDDINNAMTQLAFAMLAAIIIVYLILVITFKGGLAPFTILFSLPFTVIGVIIALLITGETISVPSLIGMLMLIGIVVTNAIVLIDRVINNEQQGMEMKEALIEAGGTRIRPILMTAIATIGALVPLLFGQDSSILISKGLAATVIGGLISSTLLTLVVVPVIYEILFTLKKRFTKR
>CP022898.1|AXJ49494.1|2322290_2322608_+|hypothetical-protein
MQFYLILLAILYLIVSFISIFKMEVIFTRILRIIMGVLLLFVLALTTMSFPKENWWVFIVLLLLVGNVEVTGFKMLKKDLKGVNILNLMSLFIFVIYFILTIVLF
>CP022898.1|AXJ49493.1|2321891_2322056_+|hypothetical-protein
MSLENQLAELKYDYVRLQGDLEKRESLNLDTSALVRQLKDIENEIRNVRAQMQD
>CP022898.1|AXJ49492.1|2320850_2321759_-|Membrane-transport-protein
MTEQFTMIILLIALGYFLKRINYIKATDSQVIATLVLNVTLPSLVIVNLNSAELKLSFSILPILMIIYGIVAKMIAVWFFRKYDNHMRGSVGMMTGAMNIGLFAYPLIEVIWPKTGLIYFGMADIGGAFVMFGITYFVGSYFSEGSDQFDFKYLGKKLLQSVPLVTYIVMFILNISHIHLPHVAIDFFSILSHANMPLSMILLGVMLNFTLERKYIPATIKYLCLHYGLALVAGLLVHVLLPVSDDMIKTTLLVTWMFPVGVAIISYGIQFKYRTLPFIGMTTNLTIIISIIILYVYQAVFV
>CP022898.1|AXJ49502.1|2331581_2332604_-|Cyclic-pyranopterin-monophosphate-synthase
MVEQIKDKLGRPIRDLRLSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTFDEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLTTNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQIDYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGNDNGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGLITSVSQSFCSTCTRARLSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELKEQFKALWQIRDDRYSDERTAQTVANRQRKKINMNYIGG
>CP022898.1|AXJ49503.1|2332623_2333223_-|putative-molybdenum-cofactor-guanylyltransferase
MKAIILAGGHSVRFGKPKAFAEVNGETFYSRVIKTLESTNMFNEIIISTNAQLATQFKYPNVVIDDENHNDKGPLAGIYTIMKQHPEEELFFVVSVDTPMITGKAVSTLYQFLVSHLIENHLDVAAFKEDGRFIPTIAFYSPNALGAITKALHSDNYSFKNVYHELSTDYLDVRDVDAPSYWYKNINYQHDLDALIQKL
>CP022898.1|AXJ49504.1|2333229_2333463_-|Molybdopterin-synthase-sulfur-carrier-subunit
MKVLYFAEIKDILQKAQEDIMLEQALTVQQFEDLLFERYPQINNKKFQVAVNEEFVQKSDFIQPNDTVALIPPVSGG
>CP022898.1|AXJ49505.1|2333468_2333915_-|Molybdopterin-synthase-catalytic-subunit
MKQFEIVTEPIQTEQYREFTINEYQGAVVVFTGHVREWTKGVKTEYLEYEAYIPMAEKKLAQIGDEINEKWPGTITSIVHRIGPLQISDIAVLIAVSSPHRKDAYRANEYAIERIKEIVPIWKKEIWEDGSKWQGHQKGNYEEAKREE
>CP022898.1|AXJ49506.1|2333928_2334414_-|Molybdopterin-guanine-dinucleotide-biosynthesis-adapter-protein
MILQIVGYKKSGKTTLMRYIVSFLKSHGYTVATIKHHGHGKEDIQLQDSDVDHMKHFEAGADQSIVQGFQYQQTVTRVDNQNLTQIIEKSVTIDTNIVLVEGFKNADFEKVVVYRNEEELQVLQQLSNVCYSINVREHEDFTAFEQWLLNKIKNDCDTQLT
>CP022898.1|AXJ49507.1|2334410_2335670_-|Molybdopterin-molybdenumtransferase
MVVEKRNPIPVKEAIQRIVNQQSSMPAITVALEKSLNHILAEDIVATYDIPRFDKSPYDGFAIRSVDSQGASGQNRIEFKVIDHIGAGSVSDKLVGDHEAVRIMTGAQIPNGADAVVMFEQTIELEDTFTIRKPFSKNENISLKGEETTTGDVVLKKGQVINPGAIAVLATYGYAEVKVIKQPSVAVIATGSELLDVNDVLEDGKIRNSNGPMIRALAEKLGLEVGIYKTQQDDLDSGIQVVKEAMEKHDIVITTGGVSVGDFDYLPEIYKAVKAEVLFNKVAMRPGSVTTVAFADGKYLFGLSGNPSACFTGFELFVKPAVKHMCGALEVFPQIIKATLMEDFTKANPFTRFIRAKATLTSAGATVVPSGFNKSGAVVAIAHANCMVMLPGGSRGFKAGHTVDIILTESDAAEEELLL
>CP022898.1|AXJ49508.1|2335732_2336227_+|Cyclic-pyranopterin-monophosphate-synthase-accessory-protein
MTEFTHINQQGHAKMVDVSDKQITKRTAVAHSSITVNETIYKQISNNTNTKGNVLNTAQIAGIMAAKNTSTIIPMCHPLPLTGIDVHFSWDETNAPLYTLNIQTTVSTTGKTGVEMEALTAASATALTIYDMTKAVDKGMIIGETYLESKSGGKSGDFQRQSGQ
>CP022898.1|AXJ49509.1|2336228_2336735_-|Molybdenum-cofactor-biosynthesis-protein-B
MGEHQNVKLNRTVKAAVLTVSDTRDFDTDKGGQCVRQLLQADDVEVSDAHYTIVKDEKLAITTQVKKWLEEDIDVIITTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPELNHLIHELTK
>CP022898.1|AXJ49510.1|2336765_2337770_-|Molybdopterin-synthase-adenylyltransferase
MSQERYSRQILFKQIGEIGQSKINQKCALIIGMGALGTHVAEGLVRAGIAKLIIVDRDYIEFSNLQRQTLFTEEDALKMMPKVVAAKKHLLALRSDVDIDDYIAHVDYYFLETHGQDVDVIIDATDNFETRQLINDFAYKHRIPWIYGGVVQSTYTEAAFIPGKTPCFNCLVPQLPALNLTCDTVGVIQPAVTMATSLQLRDAMKVLTEQPIDTKITYGDIWEGSHYSFGFSKMQRSACTTCGDVPSYPYLNKNEQRYATLCGRDTVQYENASITHDILVQFLKQHQLNYRSNSYMVMFEFKGHRIVAFKGGRFLIHGMTRTSDATHLMNLLFG
>CP022898.1|AXJ49511.1|2337938_2338544_-|Sulfate/thiosulfate-import-ATP-binding-protein-CysA
MLKINLKYQLKNTLIRININDTEPKIYAVRGPSGIGKTTVLNMIAGLRKADEAIIEVNGQLLTDTAKNVNVKIQQRRIGYLFQDYQLFPNMTVYKNITFMAEPSEHIDQLIQTLNIDHLMKQYPMTLSGGEAQRVSLARALSTKPDLILLDEPFSSLDDTTKDESITLVKRIFNEWQIPIIFVTHSNYEAEQMAHEIITIG

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Crispr_ID: CP022898_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022898_7

2394077-2394170

Orphan

Consensus_repeat	Method
TAACTTAAGTTATTAGAGCCTCTTATGCAGTTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022898_7

>merge|CP022898|7|2394077-2394170|CRISPRCasFinder
TAACTTAAGTTATTAGAGCCTCTTATGCAGTTGCGTAGTCAACTGTATACCTTTTGCCTTTAACTTAAGTTATTAGAGCCTCTTATGCAGTTGC

>CP022898|7|7|2394077-2394170|CRISPRCasFinder
TAACTTAAGTTATTAGAGCCTCTTATGCAGTTGC	GTAGTCAACTGTATACCTTTTGCCTT
TAACTTAAGTTATTAGAGCCTCTTATGCAGTTGC

Protein	Signature genes	Signature genes Name	Protein_function
CP022898.1\|AXJ49560.1\|2386684_2387257_-\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49572.1\|2400821_2402054_-\|ABC-2-family-transporter-protein	unknown	unknown	gnl\|CDD\|224582
CP022898.1\|AXJ49562.1\|2388735_2389857_-\|putative-hydrolase-YxeP	unknown	unknown	gnl\|CDD\|349919
CP022898.1\|AXJ49570.1\|2399228_2400248_-\|Aldose-1-epimerase-precursor	unknown	unknown	gnl\|CDD\|185696
CP022898.1\|AXJ49559.1\|2385146_2386460_-\|Malate-2H(+)/Na(+)-lactate-antiporter	unknown	unknown	gnl\|CDD\|224671
CP022898.1\|AXJ49555.1\|2381121_2381652_+\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49556.1\|2381717_2383322_-\|PTS-system-maltose-specific-EIICB-component	unknown	unknown	gnl\|CDD\|273925
CP022898.1\|AXJ49563.1\|2390134_2391373_-\|Imidazolonepropionase	unknown	unknown	gnl\|CDD\|236478
CP022898.1\|AXJ49571.1\|2400277_2400604_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224656
CP022898.1\|AXJ49574.1\|2403176_2403833_-\|Inner-membrane-protein-YhaI	unknown	unknown	gnl\|CDD\|225694
CP022898.1\|AXJ49569.1\|2398339_2398993_+\|6-N-hydroxylaminopurine-resistance-protein	unknown	unknown	gnl\|CDD\|225167
CP022898.1\|AXJ49564.1\|2391372_2393034_-\|Urocanate-hydratase	unknown	unknown	gnl\|CDD\|235448
CP022898.1\|AXJ49561.1\|2387743_2388625_-\|putative-oxidoreductase-YghA	unknown	unknown	gnl\|CDD\|181188
CP022898.1\|AXJ49573.1\|2402046_2402946_-\|putative-ABC-transporter-ATP-binding-protein-YxlF	unknown	unknown	gnl\|CDD\|226631
CP022898.1\|AXJ49558.1\|2384473_2384980_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226353
CP022898.1\|AXJ49567.1\|2396161_2397418_+\|Lysostaphin-resistance-protein-A	unknown	unknown	gnl\|CDD\|224185
CP022898.1\|AXJ49568.1\|2397482_2398169_-\|Ribose-5-phosphate-isomerase-A	unknown	unknown	gnl\|CDD\|184433
CP022898.1\|AXJ49566.1\|2394936_2395872_-\|Formimidoylglutamase	unknown	unknown	gnl\|CDD\|184317
CP022898.1\|AXJ49557.1\|2383651_2384416_+\|HTH-type-transcriptional-regulator-GlvR	unknown	unknown	gnl\|CDD\|224651
CP022898.1\|AXJ49575.1\|2404231_2404840_+\|3-methyladenine-DNA-glycosylase	unknown	unknown	gnl\|CDD\|225005

Protein	Function_ID	Function_description	E-value
CP022898.1\|AXJ49559.1\|2385146_2386460_-\|Malate-2H(+)/Na(+)-lactate-antiporter	gnl\|CDD\|224671	COG1757, NhaC, Na+/H+ antiporter [Energy production and conversion].	2.62746e-90
CP022898.1\|AXJ49572.1\|2400821_2402054_-\|ABC-2-family-transporter-protein	gnl\|CDD\|224582	COG1668, NatB, ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism].	1.87659e-72
CP022898.1\|AXJ49570.1\|2399228_2400248_-\|Aldose-1-epimerase-precursor	gnl\|CDD\|185696	cd09019, galactose_mutarotase_like, galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.	9.6517e-99
CP022898.1\|AXJ49563.1\|2390134_2391373_-\|Imidazolonepropionase	gnl\|CDD\|236478	PRK09356, PRK09356, imidazolonepropionase; Validated.	0
CP022898.1\|AXJ49556.1\|2381717_2383322_-\|PTS-system-maltose-specific-EIICB-component	gnl\|CDD\|273925	TIGR02005, PTS-IIBC-alpha, PTS system, alpha-glucoside-specific IIBC component. This model represents a family of fused PTS enzyme II B and C domains. A gene from Clostridium has been partially characterized as a maltose transporter, while genes from Fusobacterium and Klebsiella have been proposed to transport the five non-standard isomers of sucrose. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
CP022898.1\|AXJ49562.1\|2388735_2389857_-\|putative-hydrolase-YxeP	gnl\|CDD\|349919	cd05669, M20_Acy1_YxeP-like, M20 Peptidase aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2. Peptidase M20 family, aminoacyclase-1 YxeP-like subfamily including YxeP, YtnL, YjiB and HipO2, most of which have not been well characterized to date. N-terminal acetylation of proteins is a widespread and highly conserved process that is involved in the protection and stability of proteins. Several types of aminoacylases can be distinguished on the basis of substrate specificity; substrates include indoleacetic acid (IAA) N-conjugates of amino acids, N-acetyl-L-amino acids and aminobenzoylglutamate. ACY1 breaks down cytosolic aliphatic N-acyl-alpha-amino acids (except L-aspartate), especially N-acetyl-methionine and acetyl-glutamate into L-amino acids and an acyl group. However, ACY1 can also catalyze the reverse reaction, the synthesis of acetylated amino acids. ACY1 may also play a role in xenobiotic bioactivation as well as in the inter-organ processing of amino acid-conjugated xenobiotic derivatives (S-substituted-N-acetyl-L-cysteine). ACY1 appears to physically interact with Sphingosine kinase type 1 (SphK1) and may influence its physiological functions; SphK1 and its product sphingosine-1-phosphate have been shown to promote cell growth and inhibit apoptosis of tumor cells. Strong expression of the human gene and its mouse ortholog Acy1 in brain, liver, and kidney suggest a role of the enzyme in amino acid metabolism of these organs.	0
CP022898.1\|AXJ49571.1\|2400277_2400604_-\|hypothetical-protein	gnl\|CDD\|224656	COG1742, COG1742, Uncharacterized conserved protein [Function unknown].	2.59201e-46
CP022898.1\|AXJ49574.1\|2403176_2403833_-\|Inner-membrane-protein-YhaI	gnl\|CDD\|225694	COG3152, COG3152, Predicted membrane protein [Function unknown].	1.59825e-23
CP022898.1\|AXJ49569.1\|2398339_2398993_+\|6-N-hydroxylaminopurine-resistance-protein	gnl\|CDD\|225167	COG2258, COG2258, Uncharacterized protein conserved in bacteria [Function unknown].	1.13942e-88
CP022898.1\|AXJ49564.1\|2391372_2393034_-\|Urocanate-hydratase	gnl\|CDD\|235448	PRK05414, PRK05414, urocanate hydratase; Provisional.	0
CP022898.1\|AXJ49561.1\|2387743_2388625_-\|putative-oxidoreductase-YghA	gnl\|CDD\|181188	PRK07985, PRK07985, SDR family oxidoreductase.	4.22697e-133
CP022898.1\|AXJ49573.1\|2402046_2402946_-\|putative-ABC-transporter-ATP-binding-protein-YxlF	gnl\|CDD\|226631	COG4152, COG4152, ABC-type uncharacterized transport system, ATPase component [General function prediction only].	1.00969e-170
CP022898.1\|AXJ49558.1\|2384473_2384980_-\|hypothetical-protein	gnl\|CDD\|226353	COG3832, COG3832, Uncharacterized conserved protein [Function unknown].	4.34585e-27
CP022898.1\|AXJ49567.1\|2396161_2397418_+\|Lysostaphin-resistance-protein-A	gnl\|CDD\|224185	COG1266, COG1266, Predicted metal-dependent membrane protease [General function prediction only].	4.08308e-11
CP022898.1\|AXJ49568.1\|2397482_2398169_-\|Ribose-5-phosphate-isomerase-A	gnl\|CDD\|184433	PRK13978, PRK13978, ribose 5-phosphate isomerase A.	7.0255e-156
CP022898.1\|AXJ49566.1\|2394936_2395872_-\|Formimidoylglutamase	gnl\|CDD\|184317	PRK13774, PRK13774, formimidoylglutamase; Provisional.	0
CP022898.1\|AXJ49557.1\|2383651_2384416_+\|HTH-type-transcriptional-regulator-GlvR	gnl\|CDD\|224651	COG1737, RpiR, Transcriptional regulators [Transcription].	3.91257e-62
CP022898.1\|AXJ49575.1\|2404231_2404840_+\|3-methyladenine-DNA-glycosylase	gnl\|CDD\|225005	COG2094, Mpg, 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair].	1.51231e-87

>CP022898.1|AXJ49564.1|2391372_2393034_-|Urocanate-hydratase
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIHQAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGPFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISFHHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK
>CP022898.1|AXJ49563.1|2390134_2391373_-|Imidazolonepropionase
MNDLIINHIAELILPRSTDKPLKGKELDELNVVKNGTVVIKDGKIVYAGQHTDDYDATETIDASGKVVSPALVDAHTHLTFGGSREHEMSLKRQGKSYLEILEMGGGILSTVNATRETSEDDLFKKAEHDLLTMIKHGVLAVESKSGYGLDRENELKQLKVSNRLAEKYDLDMKHTFLGPHAVPKEASSNEAFLEEMIALLPEVKQYADFADIFCETGVFTIEQSQHYMQKAKEAGFKVKIHADEIDPLGGLELAIDEQAISADHLVASSDKGKEKLRNSDTVAVLLPATTFYLGKEDYADARGMLDNNGAIALATDYNPGSSVTNNLQLVMAIAALKLKLSPNEVWNAVTVNAAKAIDINAGTINTGDKANLVIWDAPNHEYIPYHFGINHAEKVIKDGKVIVDNTLSFKA
>CP022898.1|AXJ49562.1|2388735_2389857_-|putative-hydrolase-YxeP
MGLKDQAVAWRRYFHQFPELSDKEFKTTQKIKDILTEHHIRILDLPLATGLVAEVGQGPSCIAVRADIDALPIQELVEQDFKSENEGVMHACGHDIHMASILATAVKLKEIEGTLTGRVKFIFQPAEELGYGAFKIIETHALKDVQAVLGFHNDPSRPVSTFAIKTGAITSAVDRFEFHIKGVGGHAAKPEQCNDPVIVLAQLINSIQSIVSRNLSAFHEAVVTIGQISCGNTWNVIADHAYVQGTVRSFDPVVRKLVETRLQDIADGLAQAYNMKINLNYTHLPGAVMNDEALTHKAIAVAQHVGYKVEMMEQPLTIGEDFSGYSQHFPSVFALIGSHSEYDLHHPQYKPDERILEKVPEYFVEFVKRLLHE
>CP022898.1|AXJ49561.1|2387743_2388625_-|putative-oxidoreductase-YghA
MAAQDPRTKFKTTDYEKQEQEVPGLQSEMTPAPDCGETSYQGHQRLQSYKMLVTGGDSAIGRAAAIAYAKEGADVAINYLPSEEQDAQEVRQVIEESGQKAVLIPGDIRDEQFNYDLVEQAYQQLGGLDNVTLVAGHQQYHDDIHGFTTEAFTETFETNVYPLFWTVQKALEYLKPGASITTTSSVQGYNPSPILHDYAASKAAIISLTKSFSEELGPKGIRVNCVAPGPFWSPLQISGGQPQSKIPTFGQKTPLGRAGQPVELCGTYVLLASEESSYTTGQVFGVSGGVQID
>CP022898.1|AXJ49560.1|2386684_2387257_-|hypothetical-protein
MALIVSRAILFLILALAFGIATVFPEQKLSLYIVFTLFVAVAIIMNVWFTHQNIKKNIIKFNKYVAFFLAFVSGLLYIGFVIYTLTIGSYDVLPIIIFAISIVLVQILENILGISIRNTRPSNKQLKVISEQSAQQFKVISLILVSVSIVFIFIALMLKWWLILAISIIVLIIIITVAMIVYEKYYTTPD
>CP022898.1|AXJ49559.1|2385146_2386460_-|Malate-2H(+)/Na(+)-lactate-antiporter
MEVHKKSNAWALFPLLLFVALFLGVGIITGDFTSMPLNVAITITVIVALLMNRKESFAKKVEVFTKGAGHSNIILMMLIFILAGAFSNTAEKMGGVKSTVNLGLSLIPENLIIVGLFVICMFVSISMGTSVGTVAAIAPVGYGFAQATDVPTALAMATVVGGAMFGDNLSMISDTTIAAVRTQHTKMKDKFRVNFKIVLPGAILTIIILYFLTNGISLNHAKNYDYNLIKVVPYILVLVLALLGVNVIIVLIGGTLLAGIIGLIDGSFGWMGLLDAVSKGIISMEDIAMIALLIGGLVGIIQHNGGIEWLLQFVRSKVKSKRGAELGIASLVSVADIATANNTISIIMSGPLAKNIADEYDVDSRKSASILDIFGGCFQGLLPYSPQVISAAGVAGISPLMLFPYSIYPILLGVCGLIAILFNFPKLKKNTSQEMKH
>CP022898.1|AXJ49558.1|2384473_2384980_-|hypothetical-protein
MAKFNVENEHVEVEIEKLYKFSPELVYEAWTKKDLLKQWFMTSARTNKEIEADVKEGGKYRIVDQQRNGKVNVIEGIYESLVMDEYVKMTIGMPGLSETQDVIEVEFFERETGGTQMLFYYRSLVEKERRFTNLEYKQKKKEYHDAMVHGFELMFDKMYHVIETSTQQ
>CP022898.1|AXJ49557.1|2383651_2384416_+|HTH-type-transcriptional-regulator-GlvR
MFLDEHINRNFDKLNDNDLHIAHFINTHIDECKNMKIQDLAQFTHASNATIHRFTRKLGFDGYSDFKSYLKFESNKTHQLPSNSIDSFKQEIDSTFSYLERVDYQLLTEKMHTASTIYLYGTGRAQLNVASEAQRILLTLHNHVIVLHDEHELKMILNKSEPNDLFFIISLSGETHELLEVTNLLQLRQKYFISVTTMKDNTLAQKANYNVYVSSNTFYLTDGTDYSSFISYHIFFETLVRKYNEYLLHNDISN
>CP022898.1|AXJ49556.1|2381717_2383322_-|PTS-system-maltose-specific-EIICB-component
MNAIKRFGSAMIVPVLMFAFFGIVLGFATLFKNPTIMGSLADQHTFWFKFWSVIESGGWVIFTHMEVVFVVGLPLSLAKKAPGHAALAALMGYLMFNTFINAILTQWPHTFGANLEKGVENVPGLKSIAGIATLDTNILGGIIISAIITWIHNRYYSKRLPEMVGVFQGLTFVVTISFFVMLPLAAITCVIWPTVQHGIGSMQHFIIASGYIGVWLYHFLERVLIPTGLHHFIYAPIEVGPVVVNHGLKAEWLQHLNEFAKSTKPLKEQFPYGFMLQGNGKVFGCLGIALAMYATTPKENRKKVAALLIPATLTAVVVGITEPLEFTFLFIAPYLFVLHAVLAASMDTLMYAFGVVGNMGGGLLDFISTNWLPLGKEHWGTYVAQVVIGLIFVAIYFFLFRFLILKFDIPLPGRKKTEEEVKLFSKQDYKNKKGDSVDSKRASTGNEYEDKAAYYLDGLGGKENIKDVTNCTTRLRLTVYDESKVADTEYFTHQQMAHGLVKSGKSIQVVVGMTVPQVREAFEQMVDDQSSEDK
>CP022898.1|AXJ49555.1|2381121_2381652_+|hypothetical-protein
MLIDKFETYIINIAGLNDRTTRKKLSKLCKSVQFCDALQFSINKQFNQYVLEISLPKQQLPYFISFLSFHQYSIFQVLSPKKINELLDSDNLYQSAKRFDINIDGLQDAFIKDKVIDIMNMFQNHTDITYTLNKSHAHIICTPEIFAKLLHTIATRNIDILSANYRSSSMSKARIS
>CP022898.1|AXJ49566.1|2394936_2395872_-|Formimidoylglutamase
MYKQGEPNLWTGRLDSETDPKKFRHFQTVTFEDLSKLEKSSRPSGVGILGYAVDEGVALNKGRIGAKEGPDAIKQAFAGLPDLNQCETLVDYGNVYHDHEELIDTQKEFAMLAAKSIANHRQTFLLGGGHDIAYAQYLATRKVYPTQSIGVINIDAHFDTRAEQQSTSGTSFRQILEEDENTDYLVLGIAQGGNTQSLFDYAKEKKIDYVFADELLSHVSPTIKDMIERFVHEHDVIMFTICMDVIDSAFAPGVSAPAVLGLYPHTVLELAKRIIPSDKVSSVSIAEMNPTYDADNRTAKLVANLVHHFLK
>CP022898.1|AXJ49567.1|2396161_2397418_+|Lysostaphin-resistance-protein-A
MKNNKISGFQWAMTIFVFFVITMALSIMLRDFQSIIGVKHFIFEVTDLAPLIAAIICILVFKYKKVQLAGLKFSISLKVIERLLLALILPLIILIIGMYSFNTFADSFILLQSTGLSVPITHILIGHILMAFVVEFGFRSYLQNIVETKMNTFFASIVVGLMYSVFSANTTYGTEFAAYNFLYTFSFSMILGELIRATKGRTIYIATTFHASMTFGLIFLFSEEIGDLFSIKVIAISTAIVAVGYIGLSLIIRGVAYLTTRRNLEELEPNNYLDHVNDDEETNHTEAEKSSSNIKDAEKTGVATASTVGIAKNDTEKTVADEPSIHEGTEKTEPQHHIDNQTESNHDEHHDITSESVESAESVKHAPQSDDLTNDSNEDEIQSLKEPATYKEDRRSSVVIDAEKHIEKTEEQSSDKNK
>CP022898.1|AXJ49568.1|2397482_2398169_-|Ribose-5-phosphate-isomerase-A
MKDVKALKLMTLNDVLSQINGDMTLGIGTGSTMELLLPQMAQLIKERGYNITGVCTSNKIAFLAKELGIKICEINDVDHIDLAIDGADEVDPSLNIIKGGGGALFREKVIDEMASRFVVVVDETKMVQYLGETFKLPVEVDKFNWYHILRKIESYADIKVERRVNEDVAFITDNGNYILDCKLPKGIDPYKFHEYLIHLTGVFETGYFLDMADQVIVGTQEGVKILEK
>CP022898.1|AXJ49569.1|2398339_2398993_+|6-N-hydroxylaminopurine-resistance-protein
MISIHVISTGKIQDLPYSSKRPMRSALDKTKISQTTWLSSTGFTGDEQAYKDHGGPHKAVCGFSKHNYALYQDDLPSLPTHAMFGENLTFDYLDESDVYFGNQYRLGEALIEVSEIREPCWKIQAKYNIPDLVKRMSTSGKTGFYFRVLKQGYVSPNDQLYLIQEAPIEHRLSVQQLNDLYYNDRQNQDMLRYALNNPFLSPTRRDKLQKMYNRTLK
>CP022898.1|AXJ49570.1|2399228_2400248_-|Aldose-1-epimerase-precursor
MIVEVEHQRQGVDLIKIDNDETKIIFTNYGARVVSWKYHDNNIVLGNVVEADEFYHSNPFKFGASIGRYSGRIDNAKFKLKGKEYQLEKNNGEHHLHGGCHGLDNKLFDYEIRNEIAQIKVIFKTVLKSADDHFPGDIDVTITHIYDADHQWSIEYEAVASEDTLFSPTNHVYFNLNRDNNVVDNHRISSNQLDMYVLDERNIVTGDILDLHEVFEDNKIKLSDIFTSQHAQLSQQMTRFGGLDHPFTVGEHKMYVENHEFMLEVDTDMPHVVFFTFNQPDEWDSPFNIYKPHSGFTLETQFLPNDINLYGEKAPSILKAGEVFNSKTSFRIEEKVEND
>CP022898.1|AXJ49571.1|2400277_2400604_-|hypothetical-protein
MLYPIFIFILAGLCEIGGGYLIWLWLREGQSSLVGLIGGAILMLYGVIATFQSFPSFGRVYAAYGGVFIIMSLIFAMVVDKQMPDKYDVIGAIICIVGVLVMLLPSRA
>CP022898.1|AXJ49572.1|2400821_2402054_-|ABC-2-family-transporter-protein
MHKFWATFSLTYIKKIKAKSFVIFMIIIAALMIGLSNIDKIINMFDDGPDKIGVAAPNEQIYKVFKQQANTFHSDAKFTKVSIEDAEKEVKKHKLDKAYIIKVNQNRTLQGTIISEKRVSHEDSQKVQALLTAIQTNMVAGELNINKEDLQKLQAQSKVDNKVISNDEVDKVSEGQKIFNYALAYGIIFLMFFIVLNYASQIAMEIASEKTSRVIEMIITSISPIQHIFAKILGVIAVAVTQIILIVLMAVICIFAFDLKDLLQGFNVEMNQLSWQIIIVGIISSIVGIMAYVLLAAILGSLTSRIEDLNQSLMPLTLLGMIAFYIAIFTINNPDGQLALITSYIPFLAPFQLVVRAQTSGLQIHEVILSSLISIVMVAVLIWIAIKTYKDSVLTFERGLFNSMKRVFKK
>CP022898.1|AXJ49573.1|2402046_2402946_-|putative-ABC-transporter-ATP-binding-protein-YxlF
MGLVIEHVTKRFGKMTAVNDISLELESGKMLGFLGRNGAGKTTTFRMILGLSEPTEGHITYNGKKLDKTMYNRIGYLPEERGLHGKLTVEEELKYLATLKGMSKTEIQQQISYWLERFDITENRKKRIDSLSKGNQQKIQLLASMLHKPELLILDEPFSGLDPVNVELLKEAFKDLNDWGSTIVYSSHRMEHVEELCDDVCILDKGQLVVSGDINHVRASNGNKKVVIESETTLPDLTHIRGIIHSENMKQGIQLTIENEDVAKDIYQVVAYQGYVKRFQVVEPSLQDIFIEKVGGKDA
>CP022898.1|AXJ49574.1|2403176_2403833_-|Inner-membrane-protein-YhaI
MEQLPQVGFMKSFVLFWKNYVNFKGRSRRSEYWYMMLWHLIFILPAFFVFFMGAVFVGIGDEIDAKVLSMFGVMILILTIIYMLLYSLATFIPNLALSVRRFHDISRTVVLPIIMCAFSIVFSIVVQFIESYYDNDFMFMPIGIVILLVLLYLIYFGLTVTMIVFLCFDSKPANKYGESPKYPSSIKNQPVTSETPEKAGTSETPKTPKTPEETDNQL
>CP022898.1|AXJ49575.1|2404231_2404840_+|3-methyladenine-DNA-glycosylase
MDFVNNDTRQIAKNLLGVKVIYQDTTQTYTGYIVETEAYLGLNDRAAHGYGGKITPKVTSLYKRGGTIYAHVMHTHLLINFVTKSEGIPEGVLIRAIEPEDGLSAMFRNRGKKGYEVTNGPGKWTKAFNIPRAIDGATLNDCRLSIDTKNRKYPKDIITSPRIGIPNKGDWTHKSLRYTVKGNPFVSRMRKSDCMFPEDTWK

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Crispr_ID: CP022898_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022898_8

2480875-2480966

Orphan

Consensus_repeat	Method
TGCGTTCCTTTATTTTCTGCGAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022898_8

>merge|CP022898|8|2480875-2480966|CRISPRCasFinder
TGCGTTCCTTTATTTTCTGCGAATTTTATGAGCTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCAACTGCGTTCCTTTATTTTCTGCGAA

>CP022898|8|8|2480875-2480966|CRISPRCasFinder
TGCGTTCCTTTATTTTCTGCGAA	TTTTATGAGCTAGAAAGGCTTATGCAGTTGACGTTTTACGTCCAAC
TGCGTTCCTTTATTTTCTGCGAA

Protein	Signature genes	Signature genes Name	Protein_function
CP022898.1\|AXJ49649.1\|2484674_2485622_+\|Gamma-hemolysin-component-C-precursor	unknown	unknown	gnl\|CDD\|369625
CP022898.1\|AXJ49646.1\|2479803_2480670_-\|Ferrous-iron-efflux-pump-FieF	unknown	unknown	gnl\|CDD\|223131
CP022898.1\|AXJ49642.1\|2476019_2476799_-\|putative-amino-acid-ABC-transporter-binding-protein-precursor	unknown	unknown	gnl\|CDD\|270429
CP022898.1\|AXJ49653.1\|2487833_2488949_-\|8-amino-7-oxononanoate-synthase/2-amino-3-ketobutyrate-coenzyme-A-ligase	unknown	unknown	gnl\|CDD\|223234
CP022898.1\|AXJ49638.1\|2472627_2472990_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|291399
CP022898.1\|AXJ49648.1\|2483140_2484106_+\|Gamma-hemolysin-component-A-precursor	unknown	unknown	gnl\|CDD\|369625
CP022898.1\|AXJ49654.1\|2488926_2489934_-\|Biotin-synthase	unknown	unknown	gnl\|CDD\|235755
CP022898.1\|AXJ49644.1\|2478532_2478637_+\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49637.1\|2472009_2472609_-\|Disulfide-bond-formation-protein-D-precursor	unknown	unknown	gnl\|CDD\|224565
CP022898.1\|AXJ49651.1\|2486652_2487120_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377623
CP022898.1\|AXJ49643.1\|2476919_2478359_-\|Multidrug-export-protein-EmrB	unknown	unknown	gnl\|CDD\|129794
CP022898.1\|AXJ49655.1\|2489935_2491294_-\|L-Lysine-8-amino-7-oxononanoate-aminotransferase	unknown	unknown	gnl\|CDD\|273109
CP022898.1\|AXJ49640.1\|2474591_2475323_-\|L-cystine-import-ATP-binding-protein-TcyC	unknown	unknown	gnl\|CDD\|224051
CP022898.1\|AXJ49645.1\|2478790_2479477_-\|2,3-bisphosphoglycerate-dependent-phosphoglycerate-mutase	unknown	unknown	gnl\|CDD\|184518
CP022898.1\|AXJ49647.1\|2481376_2482687_+\|Immunoglobulin-binding-protein-sbi-precursor	unknown	unknown	gnl\|CDD\|288473
CP022898.1\|AXJ49650.1\|2485623_2486601_+\|Gamma-hemolysin-component-B-precursor	unknown	unknown	gnl\|CDD\|273388
CP022898.1\|AXJ49641.1\|2475319_2476048_-\|L-cystine-transport-system-permease-protein-TcyB	unknown	unknown	gnl\|CDD\|223836
CP022898.1\|AXJ49652.1\|2487130_2487823_-\|6-carboxyhexanoate--CoA-ligase	unknown	unknown	gnl\|CDD\|224342
CP022898.1\|AXJ49639.1\|2473244_2474495_+\|Aminoacyltransferase-FemA	unknown	unknown	gnl\|CDD\|367067
CP022898.1\|AXJ49656.1\|2491271_2491958_-\|ATP-dependent-dethiobiotin-synthetase-BioD-1	unknown	unknown	gnl\|CDD\|223210

Protein	Function_ID	Function_description	E-value
CP022898.1\|AXJ49649.1\|2484674_2485622_+\|Gamma-hemolysin-component-C-precursor	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	4.1102e-93
CP022898.1\|AXJ49646.1\|2479803_2480670_-\|Ferrous-iron-efflux-pump-FieF	gnl\|CDD\|223131	COG0053, MMT1, Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism].	7.66469e-90
CP022898.1\|AXJ49642.1\|2476019_2476799_-\|putative-amino-acid-ABC-transporter-binding-protein-precursor	gnl\|CDD\|270429	cd13711, PBP2_Ngo0372_TcyA, Substrate binding domain of ABC transporters involved in cystine import; the type 2 periplasmic binding protein fold. This subgroup includes cystine-binding domain of periplasmic receptor-dependent ATP-binding cassette transporters from Neisseria gonorrhoeae and Bacillus subtilis and their related proteins. Cystine is an oxidized dimeric form of cysteine that is required for optimal bacterial growth. In Bacillus subtilis, three ABC transporters, TcyJKLMN (YtmJKLMN), TcyABC (YckKJI), and YxeMNO are involved in uptake of cystine. Likewise, three uptake systems were identified in Salmonella enterica serovar Typhimurium, while in Escherichia coli, two transport systems seem to be involved in cystine uptake. Moreover, L-cystine limitation was shown to prevent virulence of Neisseria gonorrhoeae; thus, its L-cystine solute receptor (Ngo0372) may be suited as target for an antimicrobial vaccine. The cystine receptor belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.35689e-100
CP022898.1\|AXJ49653.1\|2487833_2488949_-\|8-amino-7-oxononanoate-synthase/2-amino-3-ketobutyrate-coenzyme-A-ligase	gnl\|CDD\|223234	COG0156, BioF, 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism].	9.08937e-138
CP022898.1\|AXJ49638.1\|2472627_2472990_-\|hypothetical-protein	gnl\|CDD\|291399	pfam14729, DUF4467, Domain of unknown function with cystatin-like fold (DUF4467). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan.	3.44071e-31
CP022898.1\|AXJ49648.1\|2483140_2484106_+\|Gamma-hemolysin-component-A-precursor	gnl\|CDD\|369625	pfam07968, Leukocidin, Leukocidin/Hemolysin toxin family.	6.13066e-97
CP022898.1\|AXJ49654.1\|2488926_2489934_-\|Biotin-synthase	gnl\|CDD\|235755	PRK06256, PRK06256, biotin synthase; Validated.	0
CP022898.1\|AXJ49639.1\|2473244_2474495_+\|Aminoacyltransferase-FemA	gnl\|CDD\|367067	pfam02388, FemAB, FemAB family. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance.	0
CP022898.1\|AXJ49637.1\|2472009_2472609_-\|Disulfide-bond-formation-protein-D-precursor	gnl\|CDD\|224565	COG1651, DsbG, Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones].	6.8825e-31
CP022898.1\|AXJ49651.1\|2486652_2487120_-\|hypothetical-protein	gnl\|CDD\|377623	pfam06177, QueT, QueT transporter. This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes, suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	0.00118414
CP022898.1\|AXJ49643.1\|2476919_2478359_-\|Multidrug-export-protein-EmrB	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	4.56422e-92
CP022898.1\|AXJ49655.1\|2489935_2491294_-\|L-Lysine-8-amino-7-oxononanoate-aminotransferase	gnl\|CDD\|273109	TIGR00508, hypothetical_protein_DESPIG_00326, adenosylmethionine-8-amino-7-oxononanoate transaminase. All members of the seed alignment have been demonstrated experimentally to act as EC 2.6.1.62, an enzyme in the biotin biosynthetic pathway. Alternate names include 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, and adenosylmethionine-8-amino-7-oxononanoate aminotransferase. The gene symbol is bioA in E. coli and BIO3 in S. cerevisiae. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	0
CP022898.1\|AXJ49640.1\|2474591_2475323_-\|L-cystine-import-ATP-binding-protein-TcyC	gnl\|CDD\|224051	COG1126, GlnQ, ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism].	4.20318e-144
CP022898.1\|AXJ49645.1\|2478790_2479477_-\|2,3-bisphosphoglycerate-dependent-phosphoglycerate-mutase	gnl\|CDD\|184518	PRK14119, gpmA, phosphoglyceromutase; Provisional.	3.52864e-167
CP022898.1\|AXJ49647.1\|2481376_2482687_+\|Immunoglobulin-binding-protein-sbi-precursor	gnl\|CDD\|288473	pfam11621, Sbi-IV, C3 binding domain 4 of IgG-bind protein SBI. This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold.	1.01337e-26
CP022898.1\|AXJ49650.1\|2485623_2486601_+\|Gamma-hemolysin-component-B-precursor	gnl\|CDD\|273388	TIGR01002, synergohymenotropic_toxin, beta-channel forming cytolysin. This family of cytolytic pore-forming proteins includes alpha toxin and leukocidin F and S subunits from Staphylococcus aureus, hemolysin II of Bacillus cereus, and related toxins. [Cellular processes, Toxin production and resistance].	5.50766e-128
CP022898.1\|AXJ49641.1\|2475319_2476048_-\|L-cystine-transport-system-permease-protein-TcyB	gnl\|CDD\|223836	COG0765, HisM, ABC-type amino acid transport system, permease component [Amino acid transport and metabolism].	3.24685e-78
CP022898.1\|AXJ49652.1\|2487130_2487823_-\|6-carboxyhexanoate--CoA-ligase	gnl\|CDD\|224342	COG1424, BioW, Pimeloyl-CoA synthetase [Coenzyme metabolism].	2.10153e-129
CP022898.1\|AXJ49656.1\|2491271_2491958_-\|ATP-dependent-dethiobiotin-synthetase-BioD-1	gnl\|CDD\|223210	COG0132, BioD, Dethiobiotin synthetase [Coenzyme metabolism].	1.38828e-70

>CP022898.1|AXJ49646.1|2479803_2480670_-|Ferrous-iron-efflux-pump-FieF
MSHNENLKLAQRGAYLSLIVYIILSIVKYVTGFVFNSAAVRADALNNMTDIIVSLAVIIGLKISIKPADRNHPYGHLKSENISSLLVSFVIMFVGIQVVIQNALRLFKEDDVVPNAITIIVSLISGLVMLIVFAVNQRLAKRTKSSSLNSAAKDNLSDSLVSIGTAIGLIFTQIGFPIVDIILATLLGLLIVYTGFGIFKEAIFMLSDGFNETELEAYRNDILEVDEVQEVKSIKGRYHGSSVFIDVTIVVDANLSLVEAHQICDNVEHHLHKKGISSVYVHPEPDHL
>CP022898.1|AXJ49645.1|2478790_2479477_-|2,3-bisphosphoglycerate-dependent-phosphoglycerate-mutase
MPKLILCRHGQSEWNAKNLFTGWEDVNLSEQGINEATRAGEKVRENNIAIDVAFTSLLTRALDTTHYILTESKQQWIPVYKSWRLNERHYGGLQGLNKDDARKEFGEEQVHIWRRSYDVKPPAETEEQREAYLADRRYNHLDKRMMPYSESLKDTLVRVIPFWTDHISQYLLDGQTVLVSAHGNSIRALIKYLEDVSDEDIINYEIKTGAPLVYELTDDLEVIDKYYL
>CP022898.1|AXJ49644.1|2478532_2478637_+|hypothetical-protein
MKLDLQTARRNLNSPNIKTRKRALKIIKQHKRAK
>CP022898.1|AXJ49643.1|2476919_2478359_-|Multidrug-export-protein-EmrB
MSKKQKLTMIITMLMGGFFGLLNETLLVTALPSIMKDFEISYTQVQWLTTAFLLTNGIVIPLSALVIQRYTTRQVFLVGITIFFLGTLLGGLSPHFATLLVARIIQALGAGIMMPLMMTTILDVFQPHERGKYMGIFGLVIGLAPAIGPTLSGYLVEYFNWRSLFHVVAPIAAVTFLIGFKTIKNVGTTIKVPIDFISVIFSVLGFGGLLYGTSSISEKGFDNPIVLVSMIGGIALVALFVLRQYRLSTPLLNFAVFKNKQFTVGIIIMGVTMVSMIGSETILPIFVQNLLHRSALDSGLTLLPGAIVMAFMSMTSGALYEKFGPRKLALVGMAIVVITTAYFVVMDEQTSTIMLATVYAIRMVGIALGLIPVMTHTMNQLKPEMNAHGSSMTNTVQQIAGSIGTAALITILSHASKNFSPTMSDYNGMNKIDMMNQIKVDTMLHGYHAGFLFALLITVVSFFCSFMLQGKKKEVDSRQ
>CP022898.1|AXJ49642.1|2476019_2476799_-|putative-amino-acid-ABC-transporter-binding-protein-precursor
MKRLLFVMIAFVFILAACGNNSSKDKEASKDSKTINVGTEGTYAPFSFHDKDGKLTGYDIDVIKAVAKEEGLKLKFNETSWDSMFAGLDAGRFDVIANQVGINPDREKKYKFSKPYTFSSAVLVIRENEKDIKDFDDVKGKKLAQTFTSNYGKLAKDKGADITKVDGFNQSMDLLLSKRVDGTFNDSLSYLDYKKQKPNAKIKAIKGNAEQSRSAFAFSKKVDDETVQKFNDGLKKIEENGELAKIGKKWFGQDVSKSK
>CP022898.1|AXJ49641.1|2475319_2476048_-|L-cystine-transport-system-permease-protein-TcyB
MVKMFLNLNSEQQHALDAAKQAFGPMLEGLVKYSIPITLVTFVLGLIIALFTALMRISTSKILRSISRVYVSIIRGTPMIVQLFIIFYGIPELGRLLTNDADNQWTLAPVVAAIIGLSLNVGAYASEIIRGGIISIPKGQTEAAYSIGMTYGQTIQRIILPQAIRVSIPALGNTFLSLIKDTSLLGFILVAEMFRKAQEVASTTYEYLTIYVLVALMYWVVCFIISIIQGIYESYIERGYRS
>CP022898.1|AXJ49640.1|2474591_2475323_-|L-cystine-import-ATP-binding-protein-TcyC
MIQLNNIHKSFNDVEVIKGIDLSVEQGEVVTLIGRSGSGKTTLLRMINALEIPTEGTVYVNGKTYTSKDKKSQIEVRKQSGMVFQSYNLFPHKTALENVMEGLITVKKLKKDEARGKSLELLEKVGLTHVKDQRPHALSGGQQQRVAIARALAMNPKVMLFDEPTSALDPELVNDVLKVIKDLANEGMTMVIVTHEMRFAKEVSNNIVFIHEGMIGEQGAPEEMFNRPKTEELKRFLNVINEE
>CP022898.1|AXJ49639.1|2473244_2474495_+|Aminoacyltransferase-FemA
MNFVTLTSDEFNAFTTKHFSHYTQSAIHYNHKVDLKGDVHLVGVKDDNGQVIAGCLLTEARTLKFFKYFYTHRGPVMDYTNQSLVAFFFKALTSYLKKQNCLYVLVDPYLIENLRNADGEIVKSYDNRAFVRTMDTLGYKHQGFPVGYDSMSQIRWLSVLDLKDKTEDQLLKEMDYQTRRNIKKTYDIGVKTKTLTIDETQTFFDLFHMAEEKHGFKFRELPYFEEMQKLYDDHAMLKLAYIDLNEYLKTLQLKQQQLTAELSGVEEALEESPNSKKNKTKRTQLEQQLNSNKRKIDNTIEQIEQDGAVLNLASALFIYNEHEVYYLSSGSNPKYNAYMGAYHLQWEMIKFAKAHHIDRYNFYGITGDFSESSEDYGVQQFKKGFNAHVEEYIGDFIKPIKPLLYKVKTYLNHKRR
>CP022898.1|AXJ49638.1|2472627_2472990_-|hypothetical-protein
MKRFVATVLLLLVFISGCGNDKYVKEIDEAVKIQNQKQEQLAKKGNGDRVDHFERKDANIYVYDKDKIIILAYKPLSNDDEVHYYAYNFSDKRVSYKQDFDSRRYYQQHDADYHEENMTN
>CP022898.1|AXJ49637.1|2472009_2472609_-|Disulfide-bond-formation-protein-D-precursor
MTKKLLTLFIVSMLILTACGKKESATTSSKNGKPLVVIYGDYKCPYCKELDEKVMPKLRKNYIDDHKVEYQFVNLAFLGKDSIVGSRASHAVLMYAPKSFLDFQKQLFAAQQDENKEWLTKELLDKHIKQLHLDKETENKIIKDYKTKDSKSWKAAEKDKKIAKDNHIKTTPTAFINGEKVEDPYDYESYEKLLKDKIK
>CP022898.1|AXJ49647.1|2481376_2482687_+|Immunoglobulin-binding-protein-sbi-precursor
MKNKYISKLLVGAATITLATMISNGEAKASENTQQTSTKHQTTQNNYVTDQQKAFYQVLHLKGITEEQRNQYIKTLREHPERAQEVFSESLKDSKNPDRRVAQQNAFYNVLKNDNLTEQEKNNYIAQIKENPDRSQQVWVESVQSSKAKERQNIENADKAIKDFQDNKAPHDKSAAYEANSKLPKDLRDKNNRFVEKVSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVQKHLQKQLDALVAQKDAEKKVAPKVEAPQIQSPQIEKPKAESPKVEVPQIQSPKVEVPQSKLLGYYQSLKDSFNYGYKYLTDTYKSYKEKYDTAKYYTDKYFKYKGTIDKTVLSVFGNGYKSYIQPLKVEDQKNYVSKSYAQVRNYVTETLNTGKVLYAFYQNPKVVKAAITTAETASSIKNIFSSFTSFFK
>CP022898.1|AXJ49648.1|2483140_2484106_+|Gamma-hemolysin-component-A-precursor
MNLKLNRKKVISMIKNKILTATLAVGLIAPLANPFIEISKAENKIEDIGQGAEIIKRTQDITSKRLAITQNIQFDFVKDKKYNKDALVVKMQGFISSRTTYSDLKKYPYIKRMIWPFQYNISLKTKDSNVDLINYLPKNKIDSADVSQKLGYNIGGNFQSAPSIGGSGSFNYSKTISYNQKNYVTEVESQNSKGVKWGVKANSFVTPNGQVSAYDQYLFAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFITTLSHERGKGDKSEFEITYGRNMDATYAYVTRHRLAVDRKHDAFKNRNVTVKYEVNWKTHEVKIKSITPK
>CP022898.1|AXJ49649.1|2484674_2485622_+|Gamma-hemolysin-component-C-precursor
MLRNKILATTLSVSLLAPLANPLLENAKAANDTEDIGKGSDIEIIKRTEDKTSNKWGVTQNIQFDFVKDKKYNKDALILKMQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTNDKYVSLINYLPKNKIESTNVSQTLGYNIGGNFQSAPSLGGNGSFNYSKSISYTQQNYVSEVEQQNSKSVLWGVKANSFATESGQKSAFDSDLFVGYKPHSKDPRDYFVPDSELPPLVQSGFNPSFIATVSHEKGSSDTSEFEITYGRNMDVTHAIKRSTHYGNSYLDGHRVHNAFVNRNYTVKYEVNWKTHEIKVKGQN
>CP022898.1|AXJ49650.1|2485623_2486601_+|Gamma-hemolysin-component-B-precursor
MKMNKLVKSSVATSMALLLLSGTANAEGKITPVSVKKVDDKVTLYKTTATADSDKFKISQILTFNFIKDKSYDKDTLVLKATGNINSGFVKPNPNDYDFSKLYWGAKYNVSISSQSNDSVNVVDYAPKNQNEEFQVQNTLGYTFGGDISISNGLSGGLNGNTAFSETINYKQESYRTTLSRNTNYKNVGWGVEAHKIMNNGWGPYGRDSFHPTYGNELFLAGRQSSAYAGQNFIAQHQMPLLSRSNFNPEFLSVLSHRQDGAKKSKITVTYQREMDLYQIRWNGFYWAGANYKNFKTRTFKSTYEIDWENHKVKLLDTKETENNK
>CP022898.1|AXJ49651.1|2486652_2487120_-|hypothetical-protein
MTSKDITQISVIAAILTILAVLKIPSIIPGLDFQLSAPAALLILAFFGIKKYFLGGLLSSVLLLIFGVFNPINVIISIIFRVIAIAVVYLLKINVLSLVLASVLGSLVSRLLLSIILNLPVWVVLLNAIPGVIFTLIVAIPLYLTLRKRMAVLLR
>CP022898.1|AXJ49652.1|2487130_2487823_-|6-carboxyhexanoate--CoA-ligase
MYSIKMRSSNQDVHISGAETICEFDKIEQTVQRFYNKGFFHENGQPDFLNIKIQKIMEPIQQIKALQIIEDDKANLQKLTQECGVTEQALNQGMTYIKNETVYTGAIILSAISGKRLDSFGQRGIRATHFSFEDINNKGDLNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFASAKIGYHRLFDIKPVNTRYGGRIIFVDDRIDLHHYISFLESTPKQVVYETV
>CP022898.1|AXJ49653.1|2487833_2488949_-|8-amino-7-oxononanoate-synthase/2-amino-3-ketobutyrate-coenzyme-A-ligase
MMFQEQIDLLQQKGLYRSLKSVGYIDRQYIEVENKRCTNYTSNDYLGLGQIAFDKDDFERFMRKYSYHLSSSRLISGSSTAYEEIETMLAGWLGYSACTILNSGYDANLALFNIFKNTNCVVFSDQENHASIIDGIKLSGLEKVIYKHLDIADLEKRLAEYPNQNIQKIIISDSVFSTNGDLVDIGQLVSLKHKYNATLILDVSHSFGIENYSNYQGIDILTSSLSKACGAYGGVILSSNDVKDMLINHGRPLIYSSSLPIYNLYFIKRNIEKLINADDRRTKLNSLSKYFNQKLKALNVNYNSSNSPIKFIEFDDIEAAENIHQTLLKHHVFTSYLRYPTVTKPMLRISLSYFHTEQDVDRLFEILHQED
>CP022898.1|AXJ49654.1|2488926_2489934_-|Biotin-synthase
MNLAKRILQGEQLTKETVLKIYEDTNIDTLDLLNEAYILRKHYFGKKVKLNMILNAKSGICPENCGYCGQSRDIKQKQRYALIPEEQIIDGAKVAHDNHIGTYCIVMSGRGPSDKEVDHISNTVRTIKSQHPQLKICACLGLTNDEQAKKLKSAGVDRYNHNINTSENYHDNVVTTHSYKDRTDTIELMKANNISPCSGVICGMGESNQDIVDMAFALKEMDADSIPINFLHPIKGTKFGSMDDLTPMKCLRIVALFRLINPTKEIRIAGGREVNLRSLQPLALKAANSIFVGDYLITGGQPNQLDYDMINDLGFEIDYDTCENKENKNDVSRAN
>CP022898.1|AXJ49655.1|2489935_2491294_-|L-Lysine-8-amino-7-oxononanoate-aminotransferase
MNYTQQLKQKDSEYVWHPFTQMGVYSKEEAIIIEKGKGSYLYDTNGNKYLDGYASLWVNVHGHNNKYLNKVIKKQLNKIAHSTLLGSSNIPSIELAEKLIEITPSNLRKVFYSDTGSASVEIAIKMAYQYWKNIDREKYAKKNKFITLNHGYHGDTIGAVSVGGIKTFHKIFKDLIFENIQVESPSFYRSNYDTENEMMTAILTNIEQILIERNDEIAGFILEPLIQGATGLFVHPKGFLKEVEKLCKKYDVLLICDEVAVGFGRTGKMFACNHEDVQPDIMCLGKAITGGYLPLAATLTSQKIYDAFLSDSHGVNTFFHGHTYTGNQIVCTVALENIRLYEKRNLLSHIETTSSTLEKQLHALKRHRNVGDVRGRGLMFGVELVTDKDSKTPLEIEKVERIVRNCKENGLMIRNLENVITFVPVLSMSNKEVKTMVRIFKKAVHNILDRKC
>CP022898.1|AXJ49656.1|2491271_2491958_-|ATP-dependent-dethiobiotin-synthetase-BioD-1
MRIFITSTNTDVGKTYVTKHLYNALKTRGHRVCVFKPFQTEERQDGTFPDLEVFKNECDLSYDITSLYTFKQPVSPHLAFKMANQIFLNKQCVLDKVKVLDKEFDFILIEGAGGIAVPIYEGTDDFYMTKDLINDCADCVISVLPSKLGAISDAIVHQDYVNQNVSASNFLIMNRYTDSYIEKDNQMTIGKLTNKTVYTFEEYATYENFSEAFLKQLIGVKNELHTTT

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Crispr_ID: CP022898_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022898_10

2783338-2783416

Orphan

Consensus_repeat	Method
TTCTCTATGTTGGGGCCCCGCCAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022898_10

>merge|CP022898|10|2783338-2783416|CRISPRCasFinder
TTCTCTATGTTGGGGCCCCGCCAACTCGCATTGCCTGTAGAATTTCTTTTCGAAATTCTCTTTGTTGGGGCCCCGCCAA

>CP022898|10|10|2783338-2783416|CRISPRCasFinder
TTCTCTATGTTGGGGCCCCGCCAA	CTCGCATTGCCTGTAGAATTTCTTTTCGAAA
TTCTCTTTGTTGGGGCCCCGCCAA

Protein	Signature genes	Signature genes Name	Protein_function
CP022898.1\|AXJ49909.1\|2786328_2786541_-\|hypothetical-protein	unknown	unknown	unknown
CP022898.1\|AXJ49906.1\|2781211_2782084_+\|Poly-beta-1,6-N-acetyl-D-glucosamine-N-deacetylase-precursor	unknown	unknown	gnl\|CDD\|188448
CP022898.1\|AXJ49908.1\|2783513_2785559_-\|Lipase-1-precursor	unknown	unknown	gnl\|CDD\|224001
CP022898.1\|AXJ49912.1\|2789737_2790316_-\|Imidazoleglycerol-phosphate-dehydratase	unknown	unknown	gnl\|CDD\|153419
CP022898.1\|AXJ49915.1\|2792556_2793171_-\|ATP-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|172153
CP022898.1\|AXJ49914.1\|2791313_2792564_-\|Histidinol-dehydrogenase	unknown	unknown	gnl\|CDD\|172308
CP022898.1\|AXJ49900.1\|2776000_2776768_-\|Tyrosine-protein-phosphatase-YwqE	unknown	unknown	gnl\|CDD\|226870
CP022898.1\|AXJ49907.1\|2782070_2783123_+\|putative-poly-beta-1,6-N-acetyl-D-glucosamine-export-protein	unknown	unknown	gnl\|CDD\|226446
CP022898.1\|AXJ49901.1\|2776764_2777457_-\|Tyrosine-protein-kinase-YwqD	unknown	unknown	gnl\|CDD\|349772
CP022898.1\|AXJ49916.1\|2793188_2794007_-\|ATP-phosphoribosyltransferase-regulatory-subunit	unknown	unknown	gnl\|CDD\|237044
CP022898.1\|AXJ49913.1\|2790284_2791298_-\|Histidinol-phosphate-aminotransferase	unknown	unknown	gnl\|CDD\|223157
CP022898.1\|AXJ49898.1\|2774786_2775263_-\|Peptide-methionine-sulfoxide-reductase-msrA/msrB	unknown	unknown	gnl\|CDD\|235497
CP022898.1\|AXJ49903.1\|2778983_2779544_-\|Biofilm-operon-icaADBC-HTH-type-negative-transcriptional-regulator-IcaR	unknown	unknown	gnl\|CDD\|376089
CP022898.1\|AXJ49911.1\|2789162_2789741_-\|Imidazole-glycerol-phosphate-synthase-subunit-HisH	unknown	unknown	gnl\|CDD\|171871
CP022898.1\|AXJ49910.1\|2788465_2789170_-\|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]-imidazole-4-carboxamide-isomerase	unknown	unknown	gnl\|CDD\|172156
CP022898.1\|AXJ49899.1\|2775265_2775766_-\|putative-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
CP022898.1\|AXJ49905.1\|2780909_2781215_+\|Poly-beta-1,6-N-acetyl-D-glucosamine-synthesis-protein-IcaD	unknown	unknown	gnl\|CDD\|188447
CP022898.1\|AXJ49902.1\|2777473_2778136_-\|Capsular-polysaccharide-type-8-biosynthesis-protein-cap8A	unknown	unknown	gnl\|CDD\|226453
CP022898.1\|AXJ49917.1\|2794310_2795435_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366688
CP022898.1\|AXJ49904.1\|2779707_2780946_+\|Poly-beta-1,6-N-acetyl-D-glucosamine-synthase	unknown	unknown	gnl\|CDD\|274866

Protein	Function_ID	Function_description	E-value
CP022898.1\|AXJ49906.1\|2781211_2782084_+\|Poly-beta-1,6-N-acetyl-D-glucosamine-N-deacetylase-precursor	gnl\|CDD\|188448	TIGR03933, Poly-beta-16-N-acetyl-D-glucosamine_N-deacetylase, intercellular adhesin biosynthesis polysaccharide N-deacetylase. A common motif in bacterial biosynthesis of polysaccharide for export is modification that follows polymerization. This model describes a subfamily of polysaccharide N-deacetylases that acts on poly-beta-1,6-N-acetyl-D-glyscosamine as produced by Staphylococcus epidermidis and S. aureus. The end product in these species is designated polysaccharide intercellular adhesin (PIA), and this gene designated icaB (intercellular adhesion protein B). [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Cellular processes, Pathogenesis].	6.15216e-151
CP022898.1\|AXJ49908.1\|2783513_2785559_-\|Lipase-1-precursor	gnl\|CDD\|224001	COG1075, LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only].	7.95891e-82
CP022898.1\|AXJ49912.1\|2789737_2790316_-\|Imidazoleglycerol-phosphate-dehydratase	gnl\|CDD\|153419	cd07914, IGPD, Imidazoleglycerol-phosphate dehydratase. Imidazoleglycerol-phosphate dehydratase (IGPD; EC 4.2.1.19) catalyzes the dehydration of imidazole glycerol phosphate to imidazole acetol phosphate, the sixth step of histidine biosynthesis in plants and microorganisms where the histidine is synthesized de novo. There is an internal repeat in the protein domain that is related by pseudo-dyad symmetry, perhaps as a result of an ancient gene duplication. The apo-form of IGPD exists as a catalytically inactive trimer which, in the presence of specific divalent metal cations such as manganese (Mn2+), cobalt (Co2+), cadmium (Cd2+), nickel (Ni2+), iron (Fe2+) and zinc (Zn2+), assembles to form a biologically active high molecular weight metalloenzyme; a 24-mer with 4-3-2 symmetry. Each 24-mer has 24 active sites, and contains around 1.5 metal ions per monomer, each monomer contributing residues to three separate active sites. IGPD enzymes are monofunctional in fungi, plants, archaea and some eubacteria while they are encoded as bifunctional enzymes in other eubacteria, such that the enzyme is fused to histidinol-phosphate phosphatase, the penultimate enzyme of the histidine biosynthesis pathway. The histidine biosynthesis pathway is a potential target for development of herbicides, and IGPD is a target for the triazole phosphonate herbicides.	7.13364e-103
CP022898.1\|AXJ49915.1\|2792556_2793171_-\|ATP-phosphoribosyltransferase	gnl\|CDD\|172153	PRK13584, hisG, ATP phosphoribosyltransferase.	2.8628e-131
CP022898.1\|AXJ49914.1\|2791313_2792564_-\|Histidinol-dehydrogenase	gnl\|CDD\|172308	PRK13770, PRK13770, histidinol dehydrogenase; Provisional.	0
CP022898.1\|AXJ49900.1\|2776000_2776768_-\|Tyrosine-protein-phosphatase-YwqE	gnl\|CDD\|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.88344e-144
CP022898.1\|AXJ49907.1\|2782070_2783123_+\|putative-poly-beta-1,6-N-acetyl-D-glucosamine-export-protein	gnl\|CDD\|226446	COG3936, COG3936, Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism].	3.49276e-114
CP022898.1\|AXJ49901.1\|2776764_2777457_-\|Tyrosine-protein-kinase-YwqD	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	2.83977e-84
CP022898.1\|AXJ49916.1\|2793188_2794007_-\|ATP-phosphoribosyltransferase-regulatory-subunit	gnl\|CDD\|237044	PRK12294, hisZ, ATP phosphoribosyltransferase regulatory subunit; Provisional.	1.26228e-173
CP022898.1\|AXJ49913.1\|2790284_2791298_-\|Histidinol-phosphate-aminotransferase	gnl\|CDD\|223157	COG0079, HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism].	1.50634e-79
CP022898.1\|AXJ49898.1\|2774786_2775263_-\|Peptide-methionine-sulfoxide-reductase-msrA/msrB	gnl\|CDD\|235497	PRK05528, PRK05528, peptide-methionine (S)-S-oxide reductase.	7.42007e-107
CP022898.1\|AXJ49903.1\|2778983_2779544_-\|Biofilm-operon-icaADBC-HTH-type-negative-transcriptional-regulator-IcaR	gnl\|CDD\|376089	pfam18665, TetR_C_37, Tetracyclin repressor-like, C-terminal domain. IcaR belongs to the tetracycline repressor (TetR) family of proteins, which are involved in a wide variety of gene regulations. It binds to a 42 bp region immediately upstream of the icaA gene. This entry represents the C-terminal domain which is involved in dimerization.	2.88245e-28
CP022898.1\|AXJ49911.1\|2789162_2789741_-\|Imidazole-glycerol-phosphate-synthase-subunit-HisH	gnl\|CDD\|171871	PRK13142, hisH, imidazole glycerol phosphate synthase subunit HisH; Provisional.	9.73797e-130
CP022898.1\|AXJ49910.1\|2788465_2789170_-\|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]-imidazole-4-carboxamide-isomerase	gnl\|CDD\|172156	PRK13587, PRK13587, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Provisional.	6.30354e-168
CP022898.1\|AXJ49899.1\|2775265_2775766_-\|putative-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.58707e-14
CP022898.1\|AXJ49905.1\|2780909_2781215_+\|Poly-beta-1,6-N-acetyl-D-glucosamine-synthesis-protein-IcaD	gnl\|CDD\|188447	TIGR03932, IcaD_partial, intracellular adhesion protein D. Members of this protein family are IcaD (intracellular adhesion protein D), which with catalytic subunit IcaA forms an N-acetylglucosaminyltransferase. In the absence of IcaC, this enzyme forms N-acetylglucosamine oligomers up to 20 in length. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides].	3.14464e-30
CP022898.1\|AXJ49902.1\|2777473_2778136_-\|Capsular-polysaccharide-type-8-biosynthesis-protein-cap8A	gnl\|CDD\|226453	COG3944, COG3944, Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane].	1.17617e-89
CP022898.1\|AXJ49917.1\|2794310_2795435_-\|hypothetical-protein	gnl\|CDD\|366688	pfam01522, Polysacc_deac_1, Polysaccharide deacetylase. This domain is found in polysaccharide deacetylase. This family of polysaccharide deacetylases includes NodB (nodulation protein B from Rhizobium) which is a chitooligosaccharide deacetylase. It also includes chitin deacetylase from yeast, and endoxylanases which hydrolyzes glucosidic bonds in xylan.	3.24426e-06
CP022898.1\|AXJ49904.1\|2779707_2780946_+\|Poly-beta-1,6-N-acetyl-D-glucosamine-synthase	gnl\|CDD\|274866	TIGR03937, Poly-beta-16-N-acetyl-D-glucosamine_synthase, poly-beta-1,6 N-acetyl-D-glucosamine synthase. Members of this protein family are biofilm-forming enzymes that polymerize N-acetyl-D-glucosamine residues in beta(1,6) linkage. One named members is IcaA (intercellular adhesin protein A), an enzyme that acts (with aid of subunit IcaD) in Polysaccharide Intercellular Adhesin (PIA) biosynthesis in Staphylococcus epidermis). The homologous member in E. coli is designated PgaC. Members are often encoded next to a polysaccharide deacetylase and involved in biofilm formation. Note that chitin, although also made from N-acetylglucosamine, is formed with beta-1,4 linkages.	0

>CP022898.1|AXJ49907.1|2782070_2783123_+|putative-poly-beta-1,6-N-acetyl-D-glucosamine-export-protein
MKKIRLELVYLRAIICAIIIVTHLLTQITLKHENMEGGSLVLQFYIRNIVIFGTPCFIILSQLLTTLNYQKVTYRYLTTRVKYILIPYILMGLFYSYSESLLTDTSFQKQFIENVLLGQWYGYFIVVIMQFFILSYIIFKINYNLFNSKILLLLSFILQQSFLYYFTNNTAFHDTVLHYYPLSENTIIFGWIFYFFLGAYMGYNYERVLNFLERYLVIMIVLAVATYFVFIALANGDYWNVTSFSYSLTPYNSIMFIVILGICTHFKTMLFNTIQMISAFSFFIYLLHPIILDSLFAYTNIFEDNTMVFLAISLLFILGLCIGVGMILREFYIFRFIIGKQPYKLNINAY
>CP022898.1|AXJ49906.1|2781211_2782084_+|Poly-beta-1,6-N-acetyl-D-glucosamine-N-deacetylase-precursor
MKYRKLIILVLSILIILPVSTLDGHHIANADDDPPKKLKYKENSALALNYHRVRKANFLNNFIYFFSSSKEIKNYSVSQSQFESQIKWLKSHDAKFLTLKEFLYYKKKGKFPKRSVWINFDDMDETIYENAYPILKKYKIPATGFIITGHVGEENFHNLDMISKKELKEMYKTGLWEFETHTHDLHNLSKNNKSKLMKSSEATIIKDLNKSEKYLTKNFKKSQKTIAYPYGLMNDDKLPVIKKAGLKYGFSLEEKAVTPNSNDYYIPRILISDDAFEHLIKRWDGFHEKD
>CP022898.1|AXJ49905.1|2780909_2781215_+|Poly-beta-1,6-N-acetyl-D-glucosamine-synthesis-protein-IcaD
MVKPRQREYPTLKSSLNIVRETALIAISCVFWIYCLVVLLVYIGTIFEIHDESINTIRVALNIENTEILDIFETMGIFAIIIFVFFTISILIQKWQRGRES
>CP022898.1|AXJ49904.1|2779707_2780946_+|Poly-beta-1,6-N-acetyl-D-glucosamine-synthase
MQFFNFLLFYPVFMSIYWIVGSIYFYFTREIRYSLNKKPDINVDELEGITFLLACYNESETIEDTLSNVLALKYEKKEIIIINDGSSDNTAELIYKIKENNDFIFVDLQENRGKANALNQGIKQASYDYVMCLDADTIVDQDAPYYMIENFKHDPKLGAVTGNPRIRNKSSILGKIQTIEYASLIGCIKRSQTLAGAVNTISGVFTLFKKSAVVDVGYWDTDMITEDIAVSWKLHLRGYRIKYEPLAMCWMLVPETLGGLWKQRVRWAQGGHEVLLRDFFSTMKTKRFPLYILMFEQIISILWVYIVLLYLGYLFITANFLDYTFMTYSFSIFLLSSFTMTFINVIQFTVALFIDSRYEKKNMAGLIFVSWYPTVYWIINAAVVLVAFPKALKRKKGGYATWSSPDRGNTQR
>CP022898.1|AXJ49903.1|2778983_2779544_-|Biofilm-operon-icaADBC-HTH-type-negative-transcriptional-regulator-IcaR
MKDKIIDNAITLFSEKGYDGTTLDDIAKSVNIKKASLYYHFDSKKSIYEQSVKCCFDYLNNIIMMNQNKSNYSIDALYQFLFEFIFDIEERYIRMYVQLSNTPEEFSGNIYGQIQDLNQSLSKEIAKFYDESKIKMTKEDFQNLILLFLESWYLKASFSQKFGAVEESKSQFKDEVYSLLNIFLKK
>CP022898.1|AXJ49902.1|2777473_2778136_-|Capsular-polysaccharide-type-8-biosynthesis-protein-cap8A
MKEKFDLVKLLNILKKNIKLLLILPAICLVVSAALTFFVMPDKYTASTQILVNMKKSSSDLAFQNVQSSLQSVNTYTEIIKSPRILDKVSREFDGQYSTAELNSFLKVTNQTNSQIITVSVTTGNKSESDKIVNRISKVFAHDMPKIMSVDNVTILSSAHDNAVKVSPIVSVNLVISIIVGIVLAILIIFLKELLDKRIKTEEDVESQLGLPILGSIQKF
>CP022898.1|AXJ49901.1|2776764_2777457_-|Tyrosine-protein-kinase-YwqD
MTNTRRSTSSLIVHEQPKSPISEKFRGIRSNIMFANPDSAVQSIVITSEAPGAGKSTIAANLAVAYAQAGYKTLIVDGDMRKPTQHYIFNLPNNEGLSSLLLNWSTYQDSIISTEIQDLDVLTSGPIPPNPSELITSRAFANLYDTLLMNYNFVIIDTPPVNTVTDAQLFSKFTGNVVYVVNSENNNKDEVKKGKELIEATGAKLLGVVLNRMPKDKSASYYAYYGTDES
>CP022898.1|AXJ49900.1|2776000_2776768_-|Tyrosine-protein-phosphatase-YwqE
MIDIHNHILVDIDDGPKTIEKSIALLKQAKDEGVTSIVATPHHLHPRYDNTFQQVLVKLAELRTHPEVQALDIKLFPGQEIRITDSILQGLDNGSIQGINRSKYLLIEFPTGEVPHYTKQLFFEIQSRGYIPIIAHPERNRSIAKNPEILYELVANGALSQLTSSSLVGGFGKNIQKLSLQFIECNLAHFVASDAHSCDQRPFLMQELFHNHKLKKYSNDIEALLRNASSVINDNFVYLDRPTKPGKVKSFLKWF
>CP022898.1|AXJ49899.1|2775265_2775766_-|putative-acetyltransferase
MVLRKVIMQDLDQIIALENIGFSPEEAATPEALKLRIEQIQETFIVAEKNDEVIGYINGPVIKERYISDDLFKNVPTNNSEGGYISVLGLVVAPNYQGQGIAGRLLNYFENLAKNQHRHGVTLTCRESLISFYEKYGYRNEGVSESCHGGIKWYNLVKNIKKDDEV
>CP022898.1|AXJ49898.1|2774786_2775263_-|Peptide-methionine-sulfoxide-reductase-msrA/msrB
MAVVYVAGGCLWGVEAFFTTIPGIIHTEAGRANGRSSKLDSPYDGYAECVKLHFDDRMLTITDIMNYLFEIIDPYSVNRQGNDIGEKYRTGLYSCVDDHLIEARQFIERRKDRDQIAVEVLPLSNYIKSAEEHQQHLEKYPEDMHMCHISKDLLNKYK
>CP022898.1|AXJ49908.1|2783513_2785559_-|Lipase-1-precursor
MMKSQNKYSIRKFSVGASSILIATLLFLSGGQAQAAEKQVNMGNSQEDTVTAQSIGDQQTRENANYQRENGVDEQQHTENLTKNLHNDKTISEENHRKTDDLNKDQLKDDKKSSLNNKNIQRDTTKNNNANPSDVNQGLEQAINDGKQSKVASQQQSKETDNSQDSNANNNLPSQSRTKEALPLNKSNQTSQREIVNKTEIEKVQPQQNNQANDKITNYNFNNEKEVKPQKDEKTLSVSDLKNNQKSPVEPTKDNDKKNGLNLLKSSAVATLPNKGTKELTAKAKGDQTNKVAKQGQYKNQDPIVLVHGFNGFTDDINPSVLAHYWGGNKMNIRQDLEENGYKAYEASISAFGSNYDRAVELYYYIKGGRVDYGAAHAAKYGHERYGKTYEGIYKDWKPGQKVHLVGHSMGGQTIRQLEELLRNGNREEIEYQKKHGGEISPLFKGNNDNMISSITTLGTPHNGTHASDLAGNEALVRQIVFDIGKMFGNKNSRVDFGLAQWGLKQKPNESYIDYVKRVKQSNLWKSKDNGFYDLTREGATDLNRKTSLNPNIVYKTYTGEATHKALNSDRQKADLNMFFPFVITGNLIGKATEKEWRENDGLVSVISSQHPFNQAYTNATDKIQKGIWQVTPTKHDWDHVDFVGQDSSDTVRTREELQDFWHHLADDLVKTEKVTDTKQA
>CP022898.1|AXJ49909.1|2786328_2786541_-|hypothetical-protein
MKKLFNEYFFTTSQATALIIFSLPMTDLFTKNFLLYMLLFIVIIGSTFFIERELSKKYSLQEKAKKLCLS
>CP022898.1|AXJ49910.1|2788465_2789170_-|1-(5-phosphoribosyl)-5-[(5--phosphoribosylamino)methylideneamino]-imidazole-4-carboxamide-isomerase
MIELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQHAREFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFPGRIYLSVDAYGEDIKVNGWEEDTELNLFSFVKQLSDIPLGGIIYTDIAKDGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASFWEGLK
>CP022898.1|AXJ49911.1|2789162_2789741_-|Imidazole-glycerol-phosphate-synthase-subunit-HisH
MIVIVDYGLGNISNVKRAIEHLGYEVVVSNNPKIIDQAETIILPGVGHFKDAMSEIKRLNLDAILAKNTDKKMIGICLGMQLMYEHSDEGDASGLGFIPGNISRIQTEYPVPHLGWNNLVSKHPMLNQDVYFVHSYQAPMSENVIAYAQYGTDIPAIVQFNNYIGIQFHPEKSGTYGLQILRQAIQGGFIND
>CP022898.1|AXJ49912.1|2789737_2790316_-|Imidazoleglycerol-phosphate-dehydratase
MIYQKQRNTAETQLNISISDDQSPSHINTGVGFLNHMLTLFTFHSGLSLNIEAQGDIDVDDHHVTEDIGIVIGQLLLEMIKDKKHFVRYGTMYIPMDETLARVVVDISGRPYLSFNATLSKEKVGTFDTELVEEFFRAVVINARLTTHIDLIRGGNTHHEIEAIFKAFSRALGIALTATDDQRVPSSKGVIE
>CP022898.1|AXJ49913.1|2790284_2791298_-|Histidinol-phosphate-aminotransferase
MIYIDKNESPVTPLDEKTMTSIISATPYNLYPDAAYEQFKDAYAKFYGLSSEQIIAGNGSDELIQKLMLIMPEGLALTLNPDFFMYQAYAAQVNREIAFVDAGSDLTFDLETILTKIDEVQPSFFIMSNPHNPSGKQFDTAFLTAIADKMKAINGYFVIDEAYLDYGMAYDVELAPHILRMRTLSKAFGIAGLRLGVLISTAETIQRIQTIEHPYPLNVFTLNIATYIFRHREETSRFLTMQRQLANQLKQIFDTHVADKMSVFPSNANFVLTKGSAAQQLGQYVYEQGFKPRFYDEQVMKGYVRYSIATASQLKQLEEIVKEWSTKYDLSKTTKHS
>CP022898.1|AXJ49914.1|2791313_2792564_-|Histidinol-dehydrogenase
MLNAQQFLNQFSLEAPLDESLYPIIRDICQEVKVHGDKALKMYNLTFDHTKTDHLEISHEQIKAAFDTLDEKTKQALQQSYERIKAYQESIKQTNQQLEKSVECYEIYHPLESVGIYVPGGKASYPSTVLMTATLAQVAGVENIVVVTPPQPNGVSQEVLAACYITQVNQVFQVGGAQSIAALTYGTETIPKVDKIVGPGNQFVAYAKKYLFGQVGIDQIAGPTEIALIIDDTADLDAIVYDVFAQAEHDELARTYVISEDAQVLKDLESRIAKALPNVDRYDIVSKSIANQHYLIHASNFDEACYVMNTIAPEHASIQTVNPQPYIEKVKYVGALFIGHYSPEVIGDYVAGPSHVLPTNRTARFTNGLSVNDFLTRNTVIHLSKDTFDQIADSAQHIAHVEALYNHQQSILIRQS
>CP022898.1|AXJ49915.1|2792556_2793171_-|ATP-phosphoribosyltransferase
MLRIAIAKGRLMDSLINYLDAIEFTTLSETLKNRERQLLLSVDNIECILVKGSDVPIYVEQGIADIGIVGSDILDERHYNVNNLLDMPFGACHFAVAAKPETTKYHKIATSYVHTAEAYFKSKGIDVELIKLSGSVELACVVDMVDGIVDIVQTGTTLEANGLVEKQHISDINARLITNKAAYFKKSQLIEQFIRSLEVSIANA
>CP022898.1|AXJ49916.1|2793188_2794007_-|ATP-phosphoribosyltransferase-regulatory-subunit
MNNSEQLIALKESETAFLKYFNKADYELVDFSVVEKLDWKQLNHEDLQQMGERNFWQHEHQIYALRNDFTDQLLRYYSMYPTAATKVAYTGLIIRNNEAAVQVGLENYAPSLANVQQSLKLFIQFIQQQLRDKVHFVVLGHYQLLDALLDKSLQTPDILSMIEERNLSGLVTYLSTEHPIVQILKENTQQQLNVLEHYIPNDHPALVELKIWERWLHTQGYNDIHLDITAQPPRSYYTGLFIQCHFAENESRVLTGGYYKGSIEGFGLGLTL
>CP022898.1|AXJ49917.1|2794310_2795435_-|hypothetical-protein
MHKKYLLLFFLLLSVALLYSCSKQNEKAQNKSVNPNEYAKHKSKMDEHWETYHGQVYHVFYHPLITDPKVAFTGDTHQAKGNNDWMITVSEFKKSLNELYKNNYIIVNPHDVYDLSSHHVKAKKIKLPKGKKPLIISIDDMNYYSYMRHHGYADRLVLDKNKHVVSETTDSKGHATYSDDNDIVPILNKFVKEHPDFSLNGEKGVVALTGYEGVLGYHTNELTSKDYTKNKKAAEEVVRAMKWDGWSFASHSYGHINFEKTSLEGIKRDTKRWKDEVEPIVGKTDMFVFPHGAQDRHTQAYDYLVDEAEFKFIAGIGPNNFTDISATNVYQDRVAIDGLNLFEFKYKLKPFFNPENVYSKKDRQFFKGNRDYEE

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP022898_4	4.1\|2083817\|34\|CP022898\|CRISPRCasFinder	2083817-2083850	34	CP022898.1	768403-768436	0	1.0
CP022898_4	4.1\|2083817\|34\|CP022898\|CRISPRCasFinder	2083817-2083850	34	CP022898.1	812720-812753	0	1.0
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	1023994-1024024	0	1.0
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	1648132-1648162	0	1.0
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	1648190-1648220	0	1.0
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	2818138-2818168	0	1.0
CP022898_1	1.1\|481036\|28\|CP022898\|CRISPRCasFinder	481036-481063	28	CP022898.1	596446-596473	1	0.964
CP022898_1	1.1\|481036\|28\|CP022898\|CRISPRCasFinder	481036-481063	28	CP022898.1	768280-768307	1	0.964
CP022898_1	1.1\|481036\|28\|CP022898\|CRISPRCasFinder	481036-481063	28	CP022898.1	1977519-1977546	1	0.964
CP022898_4	4.1\|2083817\|34\|CP022898\|CRISPRCasFinder	2083817-2083850	34	CP022898.1	329448-329481	1	0.971
CP022898_4	4.1\|2083817\|34\|CP022898\|CRISPRCasFinder	2083817-2083850	34	CP022898.1	329503-329536	1	0.971
CP022898_4	4.1\|2083817\|34\|CP022898\|CRISPRCasFinder	2083817-2083850	34	CP022898.1	722310-722343	1	0.971
CP022898_4	4.1\|2083817\|34\|CP022898\|CRISPRCasFinder	2083817-2083850	34	CP022898.1	1125825-1125858	1	0.971
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	236701-236731	1	0.968
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	596387-596417	1	0.968
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	768393-768423	1	0.968
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	926089-926119	1	0.968
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	1053727-1053757	1	0.968
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	1682272-1682302	1	0.968
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	1977462-1977492	1	0.968
CP022898_1	1.1\|481036\|28\|CP022898\|CRISPRCasFinder	481036-481063	28	CP022898.1	1217265-1217292	2	0.929
CP022898_4	4.1\|2083817\|34\|CP022898\|CRISPRCasFinder	2083817-2083850	34	CP022898.1	816887-816920	2	0.941
CP022898_4	4.1\|2083817\|34\|CP022898\|CRISPRCasFinder	2083817-2083850	34	CP022898.1	1382853-1382886	2	0.941
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	329406-329436	2	0.935
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	481149-481179	2	0.935
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	481207-481237	2	0.935
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	777377-777407	2	0.935
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	816797-816827	2	0.935
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	CP022898.1	1770445-1770475	2	0.935

1. spacer 4.1|2083817|34|CP022898|CRISPRCasFinder matches to position: 768403-768436, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

2. spacer 4.1|2083817|34|CP022898|CRISPRCasFinder matches to position: 812720-812753, mismatch: 0, identity: 1.0

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctgtgttgg	Protospacer
**********************************

3. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 1023994-1024024, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

4. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 1648132-1648162, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

5. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 1648190-1648220, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

6. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 2818138-2818168, mismatch: 0, identity: 1.0

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttcttttcgaaa	Protospacer
*******************************

7. spacer 1.1|481036|28|CP022898|CRISPRCasFinder matches to position: 596446-596473, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

8. spacer 1.1|481036|28|CP022898|CRISPRCasFinder matches to position: 768280-768307, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

9. spacer 1.1|481036|28|CP022898|CRISPRCasFinder matches to position: 1977519-1977546, mismatch: 1, identity: 0.964

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacgataatgtgca	Protospacer
********************** *****

10. spacer 4.1|2083817|34|CP022898|CRISPRCasFinder matches to position: 329448-329481, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctttgttgg	Protospacer
*************************** ******

11. spacer 4.1|2083817|34|CP022898|CRISPRCasFinder matches to position: 329503-329536, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctatgttgg	Protospacer
***************************.******

12. spacer 4.1|2083817|34|CP022898|CRISPRCasFinder matches to position: 722310-722343, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattctctttgttgg	Protospacer
*************************** ******

13. spacer 4.1|2083817|34|CP022898|CRISPRCasFinder matches to position: 1125825-1125858, mismatch: 1, identity: 0.971

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaattatctgtgttgg	Protospacer
*********************** **********

14. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 236701-236731, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

15. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 596387-596417, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

16. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 768393-768423, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcttgtagaatttcttttcgaaa	Protospacer
**********.********************

17. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 926089-926119, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

18. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 1053727-1053757, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattacctgtagaatttcttttcgaaa	Protospacer
********.**********************

19. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 1682272-1682302, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcattgcctgtagaatttctttacgaaa	Protospacer
************************* *****

20. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 1977462-1977492, mismatch: 1, identity: 0.968

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcttttcgaaa	Protospacer
**.****************************

21. spacer 1.1|481036|28|CP022898|CRISPRCasFinder matches to position: 1217265-1217292, mismatch: 2, identity: 0.929

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaagtcagcttacaataatgtgca	Protospacer
*****************.**** *****

22. spacer 4.1|2083817|34|CP022898|CRISPRCasFinder matches to position: 816887-816920, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtagaatttcttttcgaaatcctctatgttgg	Protospacer
**********************.****.******

23. spacer 4.1|2083817|34|CP022898|CRISPRCasFinder matches to position: 1382853-1382886, mismatch: 2, identity: 0.941

ttgtagaatttcttttcgaaattctctgtgttgg	CRISPR spacer
ttgtgggatttcttttcgaaattctctgtgttgg	Protospacer
****.*.***************************

24. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 329406-329436, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaattccttttcgaaa	Protospacer
**.*****************.**********

25. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 481149-481179, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgtctgtagaatttcttttcgaaa	Protospacer
**.******.*********************

26. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 481207-481237, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgtctgtagaatttcttttcgaaa	Protospacer
**.******.*********************

27. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 777377-777407, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgcctgtagaatttcatttcgaaa	Protospacer
**.******************* ********

28. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 816797-816827, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
ctcgcactgcctgtagaatttctttttgaaa	Protospacer
******.*******************.****

29. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to position: 1770445-1770475, mismatch: 2, identity: 0.935

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
cttgcattgtctgtagaatttcttttcgaaa	Protospacer
**.******.*********************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP022898_1	1.1\|481036\|28\|CP022898\|CRISPRCasFinder	481036-481063	28	NC_021536	Synechococcus phage S-IOM18 genomic sequence	159754-159781	5	0.821
CP022898_7	7.1\|2394111\|26\|CP022898\|CRISPRCasFinder	2394111-2394136	26	MN545971	Citrobacter virus HCF1, complete genome	42896-42921	5	0.808
CP022898_1	1.1\|481036\|28\|CP022898\|CRISPRCasFinder	481036-481063	28	LN846932	Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome	10627-10654	6	0.786
CP022898_2	2.1\|1041971\|29\|CP022898\|CRISPRCasFinder	1041971-1041999	29	NZ_CP015322	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence	703321-703349	6	0.793
CP022898_1	1.1\|481036\|28\|CP022898\|CRISPRCasFinder	481036-481063	28	NZ_CP015319	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123a	9464-9491	7	0.75
CP022898_10	10.1\|2783362\|31\|CP022898\|CRISPRCasFinder	2783362-2783392	31	NZ_CP009619	Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence	270870-270900	8	0.742

1. spacer 1.1|481036|28|CP022898|CRISPRCasFinder matches to NC_021536 (Synechococcus phage S-IOM18 genomic sequence) position: , mismatch: 5, identity: 0.821

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaactcaccttacgataaaattta	Protospacer
******* *** ***********.* .*

2. spacer 7.1|2394111|26|CP022898|CRISPRCasFinder matches to MN545971 (Citrobacter virus HCF1, complete genome) position: , mismatch: 5, identity: 0.808

gtagtcaactgtataccttttgcctt	CRISPR spacer
gtagtcaaccgtataacttttgcgcg	Protospacer
*********.***** ******* .

3. spacer 1.1|481036|28|CP022898|CRISPRCasFinder matches to LN846932 (Carnobacterium maltaromaticum strain LMA28 LMA_pa plamid, complete genome) position: , mismatch: 6, identity: 0.786

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
acgaaaaatcagattacgataaattagt	Protospacer
*******.**** ********** *.

4. spacer 2.1|1041971|29|CP022898|CRISPRCasFinder matches to NZ_CP015322 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence) position: , mismatch: 6, identity: 0.793

taaaagagggatacttgcgctgagcgcat	CRISPR spacer
gatcaaagggttccttgcgctgagcgcat	Protospacer
 *  *.**** * ****************

5. spacer 1.1|481036|28|CP022898|CRISPRCasFinder matches to NZ_CP015319 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123a) position: , mismatch: 7, identity: 0.75

acgaaaagtcagcttacgataaagtgca	CRISPR spacer
tcgaaatgtcagcttacgaaaaagcttt	Protospacer
 ***** ************ ****. .

6. spacer 10.1|2783362|31|CP022898|CRISPRCasFinder matches to NZ_CP009619 (Vibrio coralliilyticus strain RE98 plasmid p380, complete sequence) position: , mismatch: 8, identity: 0.742

ctcgcattgcctgtagaatttcttttcgaaa	CRISPR spacer
gctgcattacctgtagcatttcttttttcaa	Protospacer
 ..*****.******* *********.  **

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

700704 : 708524

Hokovirus(16.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ47974.1\|700704_701760_-	Histidine protein kinase SaeS	A0A1V0SGX0	Hokovirus	3.6e-14	29.8
AXJ47975.1\|701759_702446_-	Response regulator SaeR	NA	NA	NA	NA
AXJ47976.1\|702420_702894_-	DoxX	NA	NA	NA	NA
AXJ47977.1\|703235_703676_-	Electron transfer DM13	NA	NA	NA	NA
AXJ47978.1\|703955_704540_-	hypothetical protein	NA	NA	NA	NA
AXJ47979.1\|704638_705352_-	7-carboxy-7-deazaguanine synthase	A0A1U9WRB6	Streptococcus_virus	6.5e-52	43.5
AXJ47980.1\|705355_705775_-	6-carboxy-5,6,7,8-tetrahydropterin synthase	S4U060	uncultured_phage	6.3e-07	28.7
AXJ47981.1\|705776_706445_-	7-cyano-7-deazaguanine synthase	A0A2H4J8Q7	uncultured_Caudovirales_phage	9.6e-66	57.1
AXJ47982.1\|706795_707389_+	Anthranilate synthase component 2	A0A0P0IKJ1	Acinetobacter_phage	1.5e-38	44.0
AXJ47983.1\|707372_708524_+	Aminodeoxychorismate synthase component 1	S4VNU7	Pandoravirus	2.1e-23	36.1

DBSCAN-SWA_2

720496 : 734689

uncultured_Caudovirales_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ47992.1\|720496_721555_+	Histidinol-phosphate aminotransferase	A0A1X6WGT4	Pacmanvirus	2.3e-21	26.4
AXJ47993.1\|721712_722255_+	Putative 5'(3')-deoxyribonucleotidase	NA	NA	NA	NA
AXJ47994.1\|722860_723778_-	Putative lipid kinase	A0A1V0SBJ0	Catovirus	2.1e-07	22.4
AXJ47995.1\|724059_725565_-	Di-/tripeptide transporter	A0A0P0IY73	Acinetobacter_phage	2.0e-58	32.2
AXJ47996.1\|725904_726405_-	NADPH-dependent 7-cyano-7-deazaguanine reductase	E7DN65	Pneumococcus_phage	2.2e-51	70.8
AXJ47997.1\|726424_727291_-	EamA-like transporter family protein	NA	NA	NA	NA
AXJ47998.1\|728091_728490_+	ribonucleotide reductase stimulatory protein	A0A2H4J545	uncultured_Caudovirales_phage	4.3e-53	72.7
AXJ47999.1\|728452_730558_+	Ribonucleoside-diphosphate reductase subunit alpha 2	A0A2H4J2N6	uncultured_Caudovirales_phage	0.0e+00	91.7
AXJ48000.1\|730675_731647_+	Ribonucleoside-diphosphate reductase subunit beta	A0A2H4J4P3	uncultured_Caudovirales_phage	4.2e-171	91.3
AXJ48001.1\|731974_732985_+	Fe(3+) dicitrate transport system permease protein FecD	A0A2H4IY97	uncultured_Caudovirales_phage	4.2e-137	78.2
AXJ48002.1\|732974_733931_+	Iron-uptake system permease protein FeuC	A0A2H4J116	uncultured_Caudovirales_phage	1.2e-05	57.8
AXJ48003.1\|733927_734689_+	putative siderophore transport system ATP-binding protein YusV	Q9EMR9	Amsacta_moorei_entomopoxvirus	5.0e-18	31.6

DBSCAN-SWA_3

821141 : 868686

Staphylococcus_virus(50.0%)

transposase,head,portal,holin,lysis,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ48087.1\|821141_822383_+	putative cysteine desulfurase	Q2XUY6	environmental_halophage	1.1e-110	44.5
AXJ48088.1\|822372_822837_+	NifU-like protein	NA	NA	NA	NA
AXJ48089.1\|822988_824386_+	FeS cluster assembly protein SufB	NA	NA	NA	NA
AXJ48090.1\|824453_825503_-\|transposase	transposase	Q9G044	Staphylococcus_virus	2.0e-203	100.0
AXJ48091.1\|825560_825932_-	hypothetical protein	Q9G043	Staphylococcus_virus	4.1e-34	100.0
AXJ48092.1\|825921_826347_-	hypothetical protein	Q9G042	Staphylococcus_virus	6.1e-74	100.0
AXJ48093.1\|826402_826588_-	hypothetical protein	Q9G041	Staphylococcus_virus	3.0e-25	100.0
AXJ48094.1\|826584_826731_-	hypothetical protein	U5U441	Staphylococcus_phage	4.3e-19	100.0
AXJ48095.1\|826742_827459_-	LexA repressor	Q9G039	Staphylococcus_virus	9.2e-131	100.0
AXJ48096.1\|827622_827865_+	hypothetical protein	Q9G038	Staphylococcus_virus	2.8e-39	100.0
AXJ48097.1\|827880_828060_+	hypothetical protein	A0A0H3U490	Staphylococcus_phage	4.4e-26	100.0
AXJ48098.1\|828160_828643_-	hypothetical protein	A0A0N9BAX2	Staphylococcus_phage	1.1e-82	100.0
AXJ48099.1\|829087_829273_+	helix-turn-helix protein	A0A0H4IP57	Staphylococcus_phage	1.3e-25	100.0
AXJ48100.1\|829274_830027_+	Phage antirepressor protein KilAC domain protein	Q9G034	Staphylococcus_virus	9.6e-139	100.0
AXJ48101.1\|830131_830797_-	hypothetical protein	Q9G033	Staphylococcus_virus	1.3e-118	100.0
AXJ48102.1\|830867_831089_+	hypothetical protein	A0A0H4ISQ0	Staphylococcus_phage	1.5e-31	100.0
AXJ48103.1\|831081_831243_+	hypothetical protein	C7F7L3	Staphylococcus_phage	1.9e-20	100.0
AXJ48104.1\|831336_831597_+	hypothetical protein	C7F7L4	Staphylococcus_phage	1.5e-43	100.0
AXJ48105.1\|831606_831828_+	hypothetical protein	A0A0E3TAJ7	Staphylococcus_phage	2.4e-34	100.0
AXJ48106.1\|831820_832600_+	hypothetical protein	Q9G028	Staphylococcus_virus	1.3e-141	99.6
AXJ48107.1\|832628_833180_+	hypothetical protein	A0A0H4IPV5	Staphylococcus_phage	3.4e-101	100.0
AXJ48108.1\|833192_833858_+	hypothetical protein	Q4ZDQ9	Staphylococcus_virus	1.7e-126	99.5
AXJ48109.1\|833859_834189_+	hypothetical protein	Q4ZDQ8	Staphylococcus_virus	3.9e-52	98.2
AXJ48110.1\|834043_834454_-	hypothetical protein	Q4ZDQ7	Staphylococcus_virus	9.4e-72	98.5
AXJ48111.1\|834516_835287_+	hypothetical protein	A0A0H4IPD8	Staphylococcus_phage	8.4e-122	100.0
AXJ48112.1\|835296_836076_+	DNA replication protein DnaC	A0A068A1Z4	Staphylococcus_phage	2.9e-146	100.0
AXJ48113.1\|836069_836228_+	hypothetical protein	A0A2I6PDX0	Staphylococcus_phage	4.5e-22	98.1
AXJ48114.1\|836241_836463_+	hypothetical protein	A0A2H4PQI9	Staphylococcus_phage	2.2e-35	100.0
AXJ48115.1\|836472_836880_+	Endodeoxyribonuclease RusA	A9CR74	Staphylococcus_phage	8.4e-73	98.5
AXJ48116.1\|836879_837065_+	hypothetical protein	M9NSS9	Staphylococcus_phage	7.0e-27	98.4
AXJ48117.1\|837065_837329_+	PVL ORF-50-like family protein	B7T0B4	Staphylococcus_virus	2.2e-34	85.9
AXJ48118.1\|837328_837499_+	hypothetical protein	Q9G017	Staphylococcus_virus	1.0e-24	100.0
AXJ48119.1\|837513_837933_+	hypothetical protein	Q9G016	Staphylococcus_virus	2.6e-77	100.0
AXJ48120.1\|837925_838078_+	hypothetical protein	Q9G015	Staphylococcus_virus	3.3e-22	100.0
AXJ48121.1\|838074_838359_+	hypothetical protein	Q9G014	Staphylococcus_virus	3.6e-46	100.0
AXJ48122.1\|838351_838594_+	hypothetical protein	Q9G013	Staphylococcus_virus	1.3e-36	100.0
AXJ48123.1\|838593_838836_+	hypothetical protein	Q9G012	Staphylococcus_virus	1.4e-35	100.0
AXJ48124.1\|838828_839365_+	dUTPase	Q9G011	Staphylococcus_virus	4.2e-96	100.0
AXJ48125.1\|839401_839608_+	hypothetical protein	A0A0H3U2R7	Staphylococcus_phage	1.3e-29	100.0
AXJ48126.1\|839604_839991_+	hypothetical protein	W5R986	Staphylococcus_phage	3.0e-64	100.0
AXJ48127.1\|839987_840161_+	Transcriptional activator RinB	Q4ZBK0	Staphylococcus_phage	6.4e-22	100.0
AXJ48128.1\|840161_840563_+	hypothetical protein	A0A2H4PQK5	Staphylococcus_phage	5.6e-69	100.0
AXJ48129.1\|840914_841409_+	Terminase small subunit	A0A0H4J343	Staphylococcus_phage	8.4e-83	100.0
AXJ48130.1\|841398_842610_+	Terminase-like family protein	A9CRA1	Staphylococcus_phage	3.6e-236	100.0
AXJ48131.1\|842623_844042_+\|portal	Phage portal protein, SPP1 Gp6-like	A0A0H4IPW9	Staphylococcus_phage	1.0e-274	100.0
AXJ48132.1\|843998_844961_+	NAD(+)--arginine ADP-ribosyltransferase EFV	Q9G003	Staphylococcus_virus	2.1e-178	100.0
AXJ48133.1\|845058_845655_+	Phage minor structural protein GP20	C7F7L8	Staphylococcus_phage	3.4e-78	100.0
AXJ48134.1\|845675_846500_+	hypothetical protein	Q9G001	Staphylococcus_virus	1.2e-147	100.0
AXJ48135.1\|846516_846843_+	hypothetical protein	Q9G000	Staphylococcus_virus	3.3e-51	100.0
AXJ48136.1\|846842_847157_+\|head,tail	Phage gp6-like head-tail connector protein	Q9FZZ9	Staphylococcus_virus	3.4e-53	100.0
AXJ48137.1\|847149_847485_+	hypothetical protein	Q9FZZ8	Staphylococcus_virus	2.3e-60	100.0
AXJ48138.1\|847471_847885_+	hypothetical protein	A0A0E3XCY8	Staphylococcus_phage	1.5e-77	100.0
AXJ48139.1\|847897_848335_+	hypothetical protein	A0A2H4PQL6	Staphylococcus_phage	1.6e-77	100.0
AXJ48140.1\|848321_848882_+	hypothetical protein	A0A0H4ITY2	Staphylococcus_phage	5.9e-101	100.0
AXJ48141.1\|848943_849438_+	Phage protein	A0A0H4IPX9	Staphylococcus_phage	2.5e-87	100.0
AXJ48142.1\|849458_849800_+	hypothetical protein	W5R8J4	Staphylococcus_phage	3.5e-56	100.0
AXJ48143.1\|849802_852772_+	hypothetical protein	Q9FZZ2	Staphylococcus_virus	6.5e-263	100.0
AXJ48144.1\|852786_853722_+\|tail	Phage tail protein	Q9FZZ1	Staphylococcus_virus	4.8e-180	100.0
AXJ48145.1\|853732_855619_+\|tail	Prophage endopeptidase tail	Q9FZZ0	Staphylococcus_virus	0.0e+00	100.0
AXJ48146.1\|855631_857530_+	hypothetical protein	Q9FZY9	Staphylococcus_virus	0.0e+00	100.0
AXJ48147.1\|857529_859353_+	hypothetical protein	Q9FZY8	Staphylococcus_virus	4.6e-296	100.0
AXJ48148.1\|859352_859730_+	hypothetical protein	Q9FZY7	Staphylococcus_virus	1.2e-60	100.0
AXJ48149.1\|859733_859907_+	hypothetical protein	A0A0F6N3L7	Staphylococcus_phage	6.6e-27	100.0
AXJ48150.1\|859947_860247_+	hypothetical protein	A0A2I6PER2	Staphylococcus_phage	2.0e-31	100.0
AXJ48151.1\|860383_862258_+	Bifunctional autolysin precursor	Q9FZY4	Staphylococcus_virus	0.0e+00	100.0
AXJ48152.1\|862270_863509_+\|tail	Phage tail repeat like protein	Q9FZY3	Staphylococcus_virus	7.7e-210	99.8
AXJ48153.1\|863514_863910_+	hypothetical protein	Q9FZY2	Staphylococcus_virus	1.6e-68	100.0
AXJ48154.1\|863966_864242_+\|holin,lysis	Phage lysis protein, holin	A0A0F6N3M0	Staphylococcus_phage	8.6e-45	100.0
AXJ48155.1\|864228_865641_+	putative cell wall hydrolase LytN precursor	Q9FZY0	Staphylococcus_virus	2.0e-286	100.0
AXJ48156.1\|865766_866609_+	Exfoliative toxin A precursor	A0A0E3T8P7	Staphylococcus_phage	2.3e-157	100.0
AXJ48157.1\|867145_867934_-	Integrase core domain protein	A0A0C5AEA5	Paenibacillus_phage	8.7e-50	51.4
AXJ48158.1\|867957_868686_-	Transposase	A0A0C5AJ29	Paenibacillus_phage	2.9e-23	35.4

DBSCAN-SWA_4

1301276 : 1331541

Bacillus_phage(30.77%)

portal,protease,capsid

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ48549.1\|1301276_1301972_-	Host cell surface-exposed lipoprotein	A0A2H4J5B8	uncultured_Caudovirales_phage	1.8e-06	40.9
AXJ48550.1\|1301983_1302367_-	hypothetical protein	NA	NA	NA	NA
AXJ48551.1\|1302562_1303882_+	Transposase	NA	NA	NA	NA
AXJ48552.1\|1304038_1304431_-	transcriptional repressor DicA	A0A2I6PE55	Staphylococcus_phage	2.7e-28	53.6
AXJ48553.1\|1304598_1304817_+	hypothetical protein	A0A2I6PE94	Staphylococcus_phage	4.9e-19	62.5
AXJ48554.1\|1304843_1305119_+	hypothetical protein	NA	NA	NA	NA
AXJ48555.1\|1305123_1305258_+	hypothetical protein	NA	NA	NA	NA
AXJ48556.1\|1305288_1305387_+	hypothetical protein	NA	NA	NA	NA
AXJ48557.1\|1305383_1305554_+	hypothetical protein	Q4ZDZ8	Staphylococcus_virus	1.8e-21	89.3
AXJ48558.1\|1305542_1305749_-	hypothetical protein	A1BTY8	Staphylococcus_virus	4.3e-25	75.0
AXJ48559.1\|1305808_1306492_+	hypothetical protein	A9CR56	Staphylococcus_phage	8.0e-108	86.0
AXJ48560.1\|1306590_1306752_+	hypothetical protein	R4IH12	Staphylococcus_phage	2.3e-13	69.8
AXJ48561.1\|1306839_1307157_+	hypothetical protein	W5RAK4	Staphylococcus_phage	9.0e-30	74.5
AXJ48562.1\|1307146_1307413_+	hypothetical protein	A0A2I6PDG2	Staphylococcus_phage	3.9e-18	53.6
AXJ48563.1\|1307417_1308668_+	hypothetical protein	A0A1B1P7L4	Bacillus_phage	1.8e-134	57.8
AXJ48564.1\|1308664_1308976_+	hypothetical protein	A0A2P0ZLA7	Lactobacillus_phage	7.0e-19	43.2
AXJ48565.1\|1308968_1309274_+	VRR-NUC domain protein	A0A1B1P7M6	Bacillus_phage	5.8e-26	59.3
AXJ48566.1\|1309263_1311090_+	PD-(D/E)XK nuclease superfamily protein	A0A1B1P7N0	Bacillus_phage	2.6e-166	56.3
AXJ48567.1\|1311107_1311314_+	hypothetical protein	NA	NA	NA	NA
AXJ48568.1\|1311359_1311842_+	hypothetical protein	A0A2H4J1S8	uncultured_Caudovirales_phage	2.9e-19	37.3
AXJ48569.1\|1312123_1313842_+	DNA polymerase II	A0A1B1P7M5	Bacillus_phage	1.9e-211	63.6
AXJ48570.1\|1313945_1314335_+	hypothetical protein	U3PG42	Staphylococcus_phage	4.5e-07	51.9
AXJ48571.1\|1314410_1314716_+	MazG nucleotide pyrophosphohydrolase domain protein	A0A2H4JF73	uncultured_Caudovirales_phage	6.2e-36	73.7
AXJ48572.1\|1314738_1315209_-	hypothetical protein	NA	NA	NA	NA
AXJ48573.1\|1315629_1315821_+	hypothetical protein	NA	NA	NA	NA
AXJ48574.1\|1315852_1317727_+	hypothetical protein	A0A1B1P7L5	Bacillus_phage	1.1e-210	57.6
AXJ48575.1\|1318031_1318523_+	positive control sigma-like factor	S5MAA9	Brevibacillus_phage	7.4e-07	30.0
AXJ48576.1\|1318955_1319246_+	HNH endonuclease	D2XR61	Bacillus_phage	1.3e-19	43.2
AXJ48577.1\|1319564_1319897_+	hypothetical protein	NA	NA	NA	NA
AXJ48578.1\|1319880_1321524_+	Phage Terminase	A0A0U4B089	Bacillus_phage	8.4e-180	57.3
AXJ48579.1\|1321539_1322676_+\|portal	Phage portal protein	A0A2H4JBZ5	uncultured_Caudovirales_phage	7.8e-84	41.4
AXJ48580.1\|1322675_1323362_+\|protease	ATP-dependent Clp protease proteolytic subunit 1	A0A2H4J8Y7	uncultured_Caudovirales_phage	1.4e-43	49.5
AXJ48581.1\|1323388_1324558_+\|capsid	Phage capsid family protein	A0A0U4JIF4	Bacillus_phage	1.2e-98	50.5
AXJ48582.1\|1324579_1324885_+	hypothetical protein	A0A059T7R0	Listeria_phage	6.0e-15	44.8
AXJ48583.1\|1324859_1325204_+	hypothetical protein	NA	NA	NA	NA
AXJ48584.1\|1325187_1325526_+	hypothetical protein	NA	NA	NA	NA
AXJ48585.1\|1325525_1325963_+	hypothetical protein	NA	NA	NA	NA
AXJ48586.1\|1325968_1326652_+	hypothetical protein	NA	NA	NA	NA
AXJ48587.1\|1326679_1327030_+	hypothetical protein	NA	NA	NA	NA
AXJ48588.1\|1327077_1327302_+	hypothetical protein	NA	NA	NA	NA
AXJ48589.1\|1327359_1331541_+	Chromosome partition protein Smc	Q9T0X1	Lactobacillus_phage	3.2e-58	42.6

DBSCAN-SWA_5

1619640 : 1627952

Staphylococcus_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ48832.1\|1619640_1620426_-	High-affinity zinc uptake system ATP-binding protein ZnuC	A0A2H4PQG7	Staphylococcus_phage	8.0e-19	28.3
AXJ48833.1\|1620551_1621442_-	putative endonuclease 4	A0A2H4UU70	Bodo_saltans_virus	2.0e-26	33.1
AXJ48834.1\|1621451_1622798_-	DEAD-box ATP-dependent RNA helicase CshB	A0A1V0SIR5	Klosneuvirus	2.4e-55	34.0
AXJ48835.1\|1622911_1624012_-	Putative GTP cyclohydrolase 1 type 2	A0A1S5V250	Saudi_moumouvirus	2.3e-08	30.6
AXJ48836.1\|1624014_1624692_-\|tRNA	tRNA (adenine(22)-N(1))-methyltransferase	NA	NA	NA	NA
AXJ48837.1\|1624822_1625929_-	RNA polymerase sigma factor SigA	A0A2I7SAT0	Vibrio_phage	1.1e-37	38.1
AXJ48838.1\|1626152_1627952_-	DNA primase	A0A0K1LMQ9	Caulobacter_phage	1.3e-53	36.3

DBSCAN-SWA_6

1697489 : 1706532

uncultured_Mediterranean_phage(50.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ48907.1\|1697489_1698008_-	Adenine phosphoribosyltransferase	A0A1V0SKE5	Klosneuvirus	5.6e-29	46.5
AXJ48908.1\|1698029_1700303_-	Single-stranded-DNA-specific exonuclease RecJ	A7KV88	Bacillus_phage	8.1e-64	29.3
AXJ48909.1\|1700505_1702785_-	bifunctional preprotein translocase subunit SecD/SecF	A0A1B1IVP7	uncultured_Mediterranean_phage	1.8e-31	35.8
AXJ48910.1\|1703059_1703320_-	preprotein translocase subunit YajC	A0A1B1IVR5	uncultured_Mediterranean_phage	8.2e-05	35.3
AXJ48911.1\|1703338_1704478_-\|tRNA	Queuine tRNA-ribosyltransferase	A0A1B1IVQ4	uncultured_Mediterranean_phage	5.4e-85	44.7
AXJ48912.1\|1704500_1705526_-\|tRNA	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	NA	NA	NA	NA
AXJ48913.1\|1705527_1706532_-	Holliday junction ATP-dependent DNA helicase RuvB	B3GAM6	uncultured_virus	1.7e-05	29.1

DBSCAN-SWA_7

1833560 : 1894148

Staphylococcus_phage(95.74%)

tRNA,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ49018.1\|1833560_1840100_-	Extracellular matrix-binding protein ebh precursor	A0A2H4PQU6	Staphylococcus_phage	9.5e-291	92.5
AXJ49019.1\|1840425_1840737_-	molybdopterin biosynthesis protein MoeB	A0A2H4PQR9	Staphylococcus_phage	4.5e-50	96.1
AXJ49020.1\|1840758_1843176_-\|tRNA	Leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	99.3
AXJ49021.1\|1843463_1844645_-	Multidrug resistance protein MdtH	A0A2H4PQR6	Staphylococcus_phage	5.6e-218	100.0
AXJ49022.1\|1844754_1845708_+	coproporphyrinogen III oxidase	A0A2H4PQV5	Staphylococcus_phage	2.2e-79	100.0
AXJ49023.1\|1845704_1846268_+	16S rRNA m(4)C1402 methyltransferase	A0A2H4PQV0	Staphylococcus_phage	8.3e-103	99.5
AXJ49024.1\|1846387_1846789_-	HTH-type transcriptional regulator rot	NA	NA	NA	NA
AXJ49025.1\|1847360_1848188_-	Phospholipase YtpA	NA	NA	NA	NA
AXJ49026.1\|1848421_1849423_+	Proline dehydrogenase 1	A0A2H4PQT6	Staphylococcus_phage	9.0e-185	99.7
AXJ49027.1\|1849544_1850009_-	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	5.8e-70	99.4
AXJ49028.1\|1850021_1851203_-	Riboflavin biosynthesis protein RibBA	A0A2H4PQS2	Staphylococcus_phage	5.1e-227	99.7
AXJ49029.1\|1851213_1851846_-	Riboflavin synthase	A0A2H4PQS5	Staphylococcus_phage	1.4e-111	98.6
AXJ49030.1\|1851852_1852896_-	Riboflavin biosynthesis protein RibD	A0A2H4PQS8	Staphylococcus_phage	9.1e-196	98.8
AXJ49031.1\|1853376_1854879_-	hypothetical protein	A0A2H4PQX2	Staphylococcus_phage	8.6e-30	98.6
AXJ49032.1\|1855399_1855714_+	Transcriptional repressor SdpR	A0A2H4PQT4	Staphylococcus_phage	2.8e-52	97.1
AXJ49033.1\|1855713_1857006_+	Arsenical pump membrane protein	A0A2H4PQU3	Staphylococcus_phage	5.7e-224	97.4
AXJ49034.1\|1857023_1857419_+	Arsenate-mycothiol transferase ArsC2	A0A2H4PQT9	Staphylococcus_phage	2.4e-72	99.2
AXJ49035.1\|1857768_1858623_-	Bifunctional autolysin precursor	Q4ZCC7	Staphylococcus_virus	9.8e-39	38.6
AXJ49036.1\|1858898_1859123_-	hypothetical protein	NA	NA	NA	NA
AXJ49037.1\|1859321_1859792_+	RNA polymerase sigma factor SigS	A0A2H4PQT5	Staphylococcus_phage	4.8e-80	96.8
AXJ49038.1\|1859904_1860348_+	hypothetical protein	NA	NA	NA	NA
AXJ49039.1\|1860334_1860778_-	hypothetical protein	A0A2H4PQT8	Staphylococcus_phage	2.4e-57	98.6
AXJ49040.1\|1861075_1861711_+\|protease	CAAX amino terminal protease self- immunity	NA	NA	NA	NA
AXJ49041.1\|1862147_1862861_-	Transaldolase	M1PR54	Cyanophage	5.5e-19	35.3
AXJ49042.1\|1863118_1863421_+	hypothetical protein	NA	NA	NA	NA
AXJ49043.1\|1863676_1864042_+	Putative fluoride ion transporter CrcB	A0A2H4PQR0	Staphylococcus_phage	6.2e-59	98.3
AXJ49044.1\|1864038_1864392_+	Putative fluoride ion transporter CrcB	A0A2H4PQQ7	Staphylococcus_phage	4.2e-20	77.8
AXJ49045.1\|1864641_1865475_-	Glyoxal reductase	A0A2H4PQR8	Staphylococcus_phage	1.2e-158	99.6
AXJ49046.1\|1865686_1866595_-	hypothetical protein	A0A2H4PQQ8	Staphylococcus_phage	3.4e-138	100.0
AXJ49047.1\|1866719_1867913_-	S-adenosylmethionine synthase	A0A2H4PQS6	Staphylococcus_phage	1.9e-218	99.7
AXJ49048.1\|1868284_1869877_+	Phosphoenolpyruvate carboxykinase [ATP]	A0A2H4PQN1	Staphylococcus_phage	0.0e+00	99.8
AXJ49049.1\|1870171_1870942_-	Prolyl oligopeptidase family protein	A0A2H4PQM6	Staphylococcus_phage	4.0e-140	97.2
AXJ49050.1\|1870922_1871402_-	Putative 8-oxo-dGTP diphosphatase YtkD	A0A2H4PQM4	Staphylococcus_phage	4.3e-84	98.1
AXJ49051.1\|1871461_1871719_+	Putative membrane protein insertion efficiency factor	A0A2H4PQM5	Staphylococcus_phage	7.2e-46	100.0
AXJ49052.1\|1871715_1872717_-	o-succinylbenzoate synthase	A0A2H4PQM0	Staphylococcus_phage	8.2e-186	97.3
AXJ49053.1\|1872721_1874200_-	2-succinylbenzoate--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	6.9e-282	96.7
AXJ49054.1\|1874358_1874841_-	hypothetical protein	A0A2H4PQN7	Staphylococcus_phage	1.1e-79	98.6
AXJ49055.1\|1875153_1875768_+	SPBc2 prophage-derived endonuclease YokF precursor	A0A2H4PQM8	Staphylococcus_phage	3.4e-25	65.2
AXJ49056.1\|1875849_1876845_+	Telomeric repeat-binding factor 2	A0A2H4PQN2	Staphylococcus_phage	2.9e-74	96.8
AXJ49057.1\|1876919_1877546_+	hypothetical protein	A0A2H4PQM7	Staphylococcus_phage	2.8e-75	92.4
AXJ49058.1\|1877586_1877928_+	hypothetical protein	A0A2H4PQN6	Staphylococcus_phage	3.0e-55	94.7
AXJ49059.1\|1878028_1878601_+	hypothetical protein	A0A2H4PQN4	Staphylococcus_phage	7.1e-25	93.1
AXJ49060.1\|1878798_1879356_-	hypothetical protein	A0A2H4PQN8	Staphylococcus_phage	2.0e-77	96.2
AXJ49061.1\|1879983_1880427_-	hypothetical protein	NA	NA	NA	NA
AXJ49062.1\|1880746_1881196_-	hypothetical protein	NA	NA	NA	NA
AXJ49063.1\|1881831_1883022_-	EcoKI restriction-modification system protein HsdS	A0A2H4PQP5	Staphylococcus_phage	1.5e-45	34.7
AXJ49064.1\|1883014_1884571_-	Type I restriction enzyme EcoKI M protein	A0A2H4PQP4	Staphylococcus_phage	2.3e-288	99.4
AXJ49065.1\|1884934_1885654_-\|protease	Serine protease SplF precursor	A0A2H4PQP1	Staphylococcus_phage	4.0e-126	95.8
AXJ49066.1\|1885779_1886499_-\|protease	Serine protease SplC precursor	A0A2H4PQP7	Staphylococcus_phage	2.4e-123	92.9
AXJ49067.1\|1886556_1887279_-\|protease	Serine protease SplB precursor	A0A2H4PQN0	Staphylococcus_phage	8.1e-127	95.8
AXJ49068.1\|1887403_1887733_-\|protease	Serine protease SplA precursor	A0A2H4PQN3	Staphylococcus_phage	6.4e-55	95.4
AXJ49069.1\|1889065_1889644_+	hypothetical protein	A0A2H4PQH6	Staphylococcus_phage	1.5e-67	74.0
AXJ49070.1\|1890117_1890336_-	hypothetical protein	A0A2H4PQH0	Staphylococcus_phage	4.1e-26	83.3
AXJ49071.1\|1890589_1891063_+	hypothetical protein	NA	NA	NA	NA
AXJ49072.1\|1891067_1891859_+	hypothetical protein	NA	NA	NA	NA
AXJ49073.1\|1892227_1893211_-	Leucotoxin LukDv precursor	A0A2H4PQH7	Staphylococcus_phage	3.4e-184	98.8
AXJ49074.1\|1893212_1894148_-	Leucotoxin LukEv precursor	A0A2H4PQI5	Staphylococcus_phage	5.1e-174	99.7

DBSCAN-SWA_8

2034224 : 2079151

Staphylococcus_phage(92.75%)

protease,holin,terminase,portal,capsid,head,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXJ49202.1\|2034224_2034575_-	Complement inhibitor precursor	A0A1P8L6B0	Staphylococcus_phage	7.5e-54	100.0
AXJ49203.1\|2035085_2035382_-	Bacterial SH3 domain protein	A0A1P8L6B4	Staphylococcus_phage	1.1e-48	94.9
AXJ49204.1\|2036071_2036563_-	Staphylokinase precursor	A0A1W6JQ12	Staphylococcus_phage	4.7e-86	99.4
AXJ49205.1\|2036753_2037509_-	putative cell wall hydrolase LytN precursor	D2JLG5	Staphylococcus_phage	9.9e-152	99.6
AXJ49206.1\|2037520_2037775_-\|holin	Bacteriophage holin	D2JLG4	Staphylococcus_phage	4.1e-41	100.0
AXJ49207.1\|2038312_2038543_-	hypothetical protein	D2JLG2	Staphylococcus_phage	1.2e-31	100.0
AXJ49208.1\|2038666_2038954_-	hypothetical protein	D2JLG1	Staphylococcus_phage	1.4e-42	98.9
AXJ49209.1\|2039000_2039153_-	hypothetical protein	D2JLG0	Staphylococcus_phage	5.2e-20	100.0
AXJ49210.1\|2039142_2042928_-	hypothetical protein	D2JLF9	Staphylococcus_phage	0.0e+00	99.4
AXJ49211.1\|2042943_2044434_-\|tail	Phage tail protein	D2JLF8	Staphylococcus_phage	8.2e-299	100.0
AXJ49212.1\|2044433_2049083_-	Murein DD-endopeptidase MepM	A0A1V0E5H1	Staphylococcus_phage	0.0e+00	99.9
AXJ49213.1\|2049320_2049767_-	hypothetical protein	O80053	Staphylococcus_phage	1.9e-73	96.6
AXJ49214.1\|2049831_2050785_-	Bacterial Ig-like domain (group 2)	A7TWD0	Staphylococcus_phage	6.2e-175	100.0
AXJ49215.1\|2050785_2051166_-	hypothetical protein	D2JLF3	Staphylococcus_phage	5.8e-68	100.0
AXJ49216.1\|2051162_2051540_-	hypothetical protein	D2JLF2	Staphylococcus_phage	1.1e-61	100.0
AXJ49217.1\|2051539_2051875_-\|head,tail	Phage head-tail joining protein	A7TWC7	Staphylococcus_phage	1.1e-59	100.0
AXJ49218.1\|2051861_2052194_-\|head,tail	Phage gp6-like head-tail connector protein	D2JLF0	Staphylococcus_phage	2.1e-58	100.0
AXJ49219.1\|2052202_2052361_-	hypothetical protein	D2JLE9	Staphylococcus_phage	3.2e-20	100.0
AXJ49220.1\|2052396_2053644_-\|capsid	Phage capsid family protein	A7TWC4	Staphylococcus_phage	4.3e-208	99.8
AXJ49221.1\|2053731_2054316_-\|head,protease	Caudovirus prohead protease	D2JLE7	Staphylococcus_phage	9.8e-107	100.0
AXJ49222.1\|2054308_2055559_-\|portal	Phage portal protein	R9QSV8	Staphylococcus_phage	1.7e-236	100.0
AXJ49223.1\|2055564_2055804_-	hypothetical protein	R9QT78	Staphylococcus_phage	5.3e-35	100.0
AXJ49224.1\|2055778_2057473_-	Phage Terminase	A0A1V0E5G5	Staphylococcus_phage	0.0e+00	100.0
AXJ49225.1\|2057475_2057943_-\|terminase	Phage terminase, small subunit	D2JLE3	Staphylococcus_phage	1.1e-81	100.0
AXJ49226.1\|2058072_2058426_-	HNH endonuclease	D2JLE2	Staphylococcus_phage	1.3e-66	100.0
AXJ49227.1\|2058432_2058885_-	hypothetical protein	D2JLE1	Staphylococcus_phage	1.4e-79	100.0
AXJ49228.1\|2058999_2059461_-	hypothetical protein	R9QT84	Staphylococcus_phage	8.1e-72	100.0
AXJ49229.1\|2059483_2059684_-	hypothetical protein	R9QT57	Staphylococcus_phage	1.1e-28	100.0
AXJ49230.1\|2059683_2059833_-	Transcriptional activator RinB	A0A1P8L6D7	Staphylococcus_phage	3.7e-18	100.0
AXJ49231.1\|2059829_2060036_-	hypothetical protein	Q4ZCV6	Staphylococcus_virus	7.1e-20	98.5
AXJ49232.1\|2060032_2060278_-	hypothetical protein	A0A0H4ITX2	Staphylococcus_phage	3.2e-35	97.5
AXJ49233.1\|2060314_2060824_-	Deoxyuridine 5'-triphosphate nucleotidohydrolase	A9CR88	Staphylococcus_phage	1.2e-89	99.4
AXJ49234.1\|2060816_2061059_-	hypothetical protein	A0A2I6PF40	Staphylococcus_phage	3.5e-34	96.2
AXJ49235.1\|2061048_2061300_-	hypothetical protein	A0A2K9VBU0	Staphylococcus_phage	1.2e-37	98.8
AXJ49236.1\|2061292_2061568_-	hypothetical protein	A0A0H4ISQ8	Staphylococcus_phage	4.0e-42	96.7
AXJ49237.1\|2061567_2061972_-	hypothetical protein	A0A0H4IPW3	Staphylococcus_phage	1.6e-71	100.0
AXJ49238.1\|2061985_2062228_-	hypothetical protein	A0A0H4ITW9	Staphylococcus_phage	4.7e-39	97.5
AXJ49239.1\|2062231_2062588_-	PVL ORF-50-like family protein	M1RZB8	Staphylococcus_phage	1.6e-59	99.2
AXJ49240.1\|2062588_2062774_-	hypothetical protein	M1SNY0	Staphylococcus_phage	1.4e-27	100.0
AXJ49241.1\|2062778_2063183_-	hypothetical protein	A0A0H4ISQ5	Staphylococcus_phage	9.0e-67	100.0
AXJ49242.1\|2063192_2063414_-	hypothetical protein	Q9G021	Staphylococcus_phage	1.3e-35	100.0
AXJ49243.1\|2063416_2063632_-	hypothetical protein	A9CR72	Staphylococcus_phage	2.8e-35	100.0
AXJ49244.1\|2063628_2064870_-	Replicative DNA helicase	C8CGZ3	Staphylococcus_phage	3.3e-229	99.8
AXJ49245.1\|2064866_2065223_-	hypothetical protein	B7T0A8	Staphylococcus_virus	2.2e-61	97.5
AXJ49246.1\|2065222_2066041_-	hypothetical protein	Q8SDW2	Staphylococcus_phage	8.9e-106	92.6
AXJ49247.1\|2066012_2066708_-	hypothetical protein	A0A0E3XBQ6	Staphylococcus_phage	1.3e-129	96.5
AXJ49248.1\|2066719_2067178_-	Single-stranded DNA-binding protein ssb	A0A0E3XC62	Staphylococcus_phage	4.2e-52	99.1
AXJ49249.1\|2067177_2067816_-	ERF superfamily protein	Q9MBS2	Staphylococcus_prophage	1.1e-114	99.5
AXJ49250.1\|2067815_2068295_-	hypothetical protein	Q4ZAD7	Staphylococcus_virus	5.8e-81	98.7
AXJ49251.1\|2068308_2068569_-	hypothetical protein	C8CGY6	Staphylococcus_phage	8.9e-44	100.0
AXJ49252.1\|2068573_2068876_-	hypothetical protein	A0A0F6N3N3	Staphylococcus_phage	7.0e-48	99.0
AXJ49253.1\|2068968_2069130_-	hypothetical protein	A0A2I6PDF7	Staphylococcus_phage	1.9e-20	100.0
AXJ49254.1\|2069126_2069447_-	hypothetical protein	Q4ZDR7	Staphylococcus_virus	1.5e-56	100.0
AXJ49255.1\|2069505_2069733_+	hypothetical protein	A7TWL9	Staphylococcus_phage	1.7e-38	100.0
AXJ49256.1\|2069734_2069926_-	hypothetical protein	A7TWL8	Staphylococcus_phage	2.8e-26	100.0
AXJ49257.1\|2069975_2070332_+	hypothetical protein	A0A1P8L6H1	Staphylococcus_phage	6.1e-59	100.0
AXJ49258.1\|2070326_2070521_-	hypothetical protein	A0A1P8L6G6	Staphylococcus_phage	4.3e-19	100.0
AXJ49259.1\|2070536_2071292_-	Phage antirepressor protein KilAC domain protein	A0A0H4J326	Staphylococcus_phage	7.4e-139	99.6
AXJ49260.1\|2071348_2071888_+	hypothetical protein	A7TW92	Staphylococcus_phage	1.7e-97	100.0
AXJ49261.1\|2071911_2072172_-	hypothetical protein	A7TW91	Staphylococcus_phage	2.7e-40	100.0
AXJ49262.1\|2072189_2072414_-	hypothetical protein	A7TW90	Staphylococcus_phage	4.5e-36	100.0
AXJ49263.1\|2072571_2073342_+	LexA repressor	A0A1P8L6G7	Staphylococcus_phage	6.2e-141	100.0
AXJ49264.1\|2073541_2073724_+	hypothetical protein	A0A2I6PDF8	Staphylococcus_phage	9.1e-27	98.3
AXJ49265.1\|2073780_2073906_+	hypothetical protein	A0A2I6PF02	Staphylococcus_phage	5.1e-13	100.0
AXJ49266.1\|2073902_2074517_-	hypothetical protein	A7TW88	Staphylococcus_phage	7.9e-107	100.0
AXJ49267.1\|2074624_2075662_+	Tyrosine recombinase XerC	A7TWL3	Staphylococcus_phage	1.7e-178	99.7
AXJ49268.1\|2075702_2076545_+	Phospholipase C precursor	A0A1P8L6H7	Staphylococcus_phage	6.7e-157	99.6
AXJ49269.1\|2077057_2078074_-	putative leukocidin-like protein 1 precursor	A0A1X9IGW5	Staphylococcus_phage	1.1e-25	30.2
AXJ49270.1\|2078095_2079151_-	putative leukocidin-like protein 2 precursor	A0A1X9IGW5	Staphylococcus_phage	1.9e-36	34.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP022898

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection