CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP022985	Mariniflexile sp. TRM1-10 chromosome, complete genome	6 crisprs	DEDDh,cas3,csa3,WYL,c2c10_CAS-V-U3	0	0	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP022985_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022985_1

912579-912707

Orphan

Consensus_repeat	Method
TTTCATGTGTTTATATCTATTCTTCTTCAATGGACACA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022985_1

>merge|CP022985|1|912579-912707|CRISPRCasFinder
TTTCATGTGTTTATATCTATTCTTCTTCAATGGACACATGCTGTTCGCTATTAATCATCCCGTTAAGTATTAAAATTTTTGAACATGCTCATTTCATGTGTTTATATCTATTCTTCTTCAATGGACACA

>CP022985|1|1|912579-912707|CRISPRCasFinder
TTTCATGTGTTTATATCTATTCTTCTTCAATGGACACA	TGCTGTTCGCTATTAATCATCCCGTTAAGTATTAAAATTTTTGAACATGCTCA
TTTCATGTGTTTATATCTATTCTTCTTCAATGGACACA

Protein	Signature genes	Signature genes Name	Protein_function
CP022985.1\|AXP79964.1\|919080_919782_-\|colicin-uptake-protein-TolQ	unknown	unknown	gnl\|CDD\|376576
CP022985.1\|AXP79966.1\|921396_922623_-\|NADP-specific-glutamate-dehydrogenase	unknown	unknown	gnl\|CDD\|223411
CP022985.1\|AXP79952.1\|903111_903210_+\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP79951.1\|902635_903100_+\|Cupin-domain-protein	unknown	unknown	gnl\|CDD\|380363
CP022985.1\|AXP79955.1\|905671_906670_-\|Acetoin:2-2C6-dichlorophenolindophenol-oxidoreductase-subunit-alpha	unknown	unknown	gnl\|CDD\|274473
CP022985.1\|AXP79962.1\|917775_918624_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274303
CP022985.1\|AXP79956.1\|906882_907365_-\|Cytidine-deaminase	unknown	unknown	gnl\|CDD\|273572
CP022985.1\|AXP79967.1\|922956_924021_-\|Anhydro-N-acetylmuramic-acid-kinase	unknown	unknown	gnl\|CDD\|236579
CP022985.1\|AXP79953.1\|903521_903914_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379428
CP022985.1\|AXP79959.1\|913197_914886_+\|Serine/threonine-protein-kinase-pkn1	unknown	unknown	gnl\|CDD\|132563
CP022985.1\|AXP79954.1\|904000_905668_-\|Dihydrolipoyllysine-residue-acetyltransferase-component-of-pyruvate-dehydrogenase-complex	unknown	unknown	gnl\|CDD\|237001
CP022985.1\|AXP79963.1\|918686_919079_-\|Biopolymer-transport-protein-ExbD	unknown	unknown	gnl\|CDD\|376792
CP022985.1\|AXP79961.1\|916555_917773_-\|Bifunctional-protein-FolC	unknown	unknown	gnl\|CDD\|223362
CP022985.1\|AXP79965.1\|919983_921381_-\|Na(+)/H(+)-antiporter-NhaD	unknown	unknown	gnl\|CDD\|215071
CP022985.1\|AXP79950.1\|901205_902594_+\|6-hydroxy-D-nicotine-oxidase	unknown	unknown	gnl\|CDD\|366708
CP022985.1\|AXP79968.1\|924115_925258_+\|Acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173847
CP022985.1\|AXP79957.1\|907459_908665_-\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP79949.1\|900814_901189_+\|Group-1-truncated-hemoglobin-GlbN	unknown	unknown	gnl\|CDD\|381253
CP022985.1\|AXP79960.1\|914977_916258_+\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	unknown	unknown	gnl\|CDD\|223841
CP022985.1\|AXP79948.1\|899605_900712_+\|Regulatory-protein-PchR	unknown	unknown	gnl\|CDD\|197666

Protein	Function_ID	Function_description	E-value
CP022985.1\|AXP79964.1\|919080_919782_-\|colicin-uptake-protein-TolQ	gnl\|CDD\|376576	pfam01618, MotA_ExbB, MotA/TolQ/ExbB proton channel family. This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels. MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller. ExbB is part of the TonB-dependent transduction complex. The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.	4.12857e-25
CP022985.1\|AXP79966.1\|921396_922623_-\|NADP-specific-glutamate-dehydrogenase	gnl\|CDD\|223411	COG0334, GdhA, Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism].	4.82723e-29
CP022985.1\|AXP79968.1\|924115_925258_+\|Acyl-CoA-dehydrogenase	gnl\|CDD\|173847	cd01158, SCAD_SBCAD, Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases. Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers.	0
CP022985.1\|AXP79951.1\|902635_903100_+\|Cupin-domain-protein	gnl\|CDD\|380363	cd02235, cupin_BLL4011-like, Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain. This family includes bacterial and fungal proteins homologous to BLL4011, a Bradyrhizobium diazoefficiens protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	2.97246e-10
CP022985.1\|AXP79955.1\|905671_906670_-\|Acetoin:2-2C6-dichlorophenolindophenol-oxidoreductase-subunit-alpha	gnl\|CDD\|274473	TIGR03182, Pyruvate_dehydrogenase_E1_component_subunit_alpha, pyruvate dehydrogenase E1 component, alpha subunit. Members of this protein family are the alpha subunit of the E1 component of pyruvate dehydrogenase (PDH). This model represents one branch of a larger family that E1-alpha proteins from 2-oxoisovalerate dehydrogenase, acetoin dehydrogenase, another PDH clade, etc. [Energy metabolism, Pyruvate dehydrogenase].	4.34636e-165
CP022985.1\|AXP79962.1\|917775_918624_-\|hypothetical-protein	gnl\|CDD\|274303	TIGR02794, Protein_TolA, TolA protein. TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis].	2.06184e-05
CP022985.1\|AXP79956.1\|906882_907365_-\|Cytidine-deaminase	gnl\|CDD\|273572	TIGR01354, Cytidine_deaminase, cytidine deaminase, homotetrameric. This small, homotetrameric zinc metalloprotein is found in humans and most bacteria. A related, homodimeric form with a much larger subunit is found in E. coli and in Arabidopsis. Both types may act on deoxycytidine as well as cytidine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides].	3.16859e-40
CP022985.1\|AXP79967.1\|922956_924021_-\|Anhydro-N-acetylmuramic-acid-kinase	gnl\|CDD\|236579	PRK09585, anmK, anhydro-N-acetylmuramic acid kinase; Reviewed.	7.04203e-120
CP022985.1\|AXP79953.1\|903521_903914_+\|hypothetical-protein	gnl\|CDD\|379428	pfam14026, DUF4242, Protein of unknown function (DUF4242). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.	5.76984e-30
CP022985.1\|AXP79959.1\|913197_914886_+\|Serine/threonine-protein-kinase-pkn1	gnl\|CDD\|132563	TIGR03524, gliding_motility_protein_GldJ, gliding motility-associated lipoprotein GldJ. Members of this protein family are exclusive to the Bacteroidetes phylum (previously Cytophaga-Flavobacteria-Bacteroides). GldJ is a lipoprotein linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae. Knockouts of GldJ abolish the gliding phenotype. GldJ is homologous to GldK. There is a GldJ homolog in Cytophaga hutchinsonii and several other species that has a different, shorter architecture and is represented by a separate model. Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Bacteroidetes with members of this protein family appear to have all of the genes associated with gliding motility.	0
CP022985.1\|AXP79954.1\|904000_905668_-\|Dihydrolipoyllysine-residue-acetyltransferase-component-of-pyruvate-dehydrogenase-complex	gnl\|CDD\|237001	PRK11856, PRK11856, branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed.	8.04712e-168
CP022985.1\|AXP79963.1\|918686_919079_-\|Biopolymer-transport-protein-ExbD	gnl\|CDD\|376792	pfam02472, ExbD, Biopolymer transport protein ExbD/TolR. This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various receptor bound substrates including colicins.	1.69734e-27
CP022985.1\|AXP79961.1\|916555_917773_-\|Bifunctional-protein-FolC	gnl\|CDD\|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	5.37216e-123
CP022985.1\|AXP79965.1\|919983_921381_-\|Na(+)/H(+)-antiporter-NhaD	gnl\|CDD\|215071	PLN00137, PLN00137, NHAD transporter family protein; Provisional.	1.3733e-117
CP022985.1\|AXP79950.1\|901205_902594_+\|6-hydroxy-D-nicotine-oxidase	gnl\|CDD\|366708	pfam01565, FAD_binding_4, FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidizes the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.	5.51261e-33
CP022985.1\|AXP79960.1\|914977_916258_+\|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase	gnl\|CDD\|223841	COG0770, MurF, UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane].	4.32735e-117
CP022985.1\|AXP79949.1\|900814_901189_+\|Group-1-truncated-hemoglobin-GlbN	gnl\|CDD\|381253	cd00454, TrHb1_N, truncated hemoglobins (TrHbs, 2/2Hb, 2/2 globins); group 1 (N). The M- and S families exhibit the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments. Truncated hemoglobins (TrHbs, 2/2Hb, or 2/2 globins) or T family globins adopt a 2-on-2 alpha-helical sandwich structure, resulting from extensive and complex modifications of the canonical 3-on-3 alpha-helical sandwich that are distributed throughout the whole protein molecule. They are classified into three main groups based on their structural properties and named after Mycobacterium sp. genes glbN, glbO, and glbP: TrHb1s (N), TrHb2s (O) and TrHb3s (P). Typical of the TrHb1s (N) group is a protein matrix tunnel. It includes a Mycobacterium tuberculosis TrHb1, Mt-trHbN, which is encoded by the glbN gene. Mt-trHbN is expressed during the Mycobacterium stationary phase, and plays a specific defense role against nitrosative stress. The cyanobacterium Synechococcus sp. PCC 7002 TrHb1 GlbN, is constitutively expressed, and likely also protects cells from reactive nitrogen species.	1.51681e-34
CP022985.1\|AXP79948.1\|899605_900712_+\|Regulatory-protein-PchR	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	6.14136e-23

>CP022985.1|AXP79957.1|907459_908665_-|hypothetical-protein
MKNQLLLLIAFVFVLKASAQEVIPLPNQDRRVITTGVPFILIAPDARAASMGDMGVATSVDAFSQQWNPSKYVFSETKSGVGVSYTPYLSKLVNDIFLGNVTYFNRLDERSAFAASFKYFSLGDIEFVADEFSEALIQRPNELTIDASYALRLSEQFAMSVAMRYLRSDLRLDGVDGDTTPASTFGVDISGYYQSEEEAYADFNGRWRMGFALQNIGPKFKYDEGGEENFQPTNLRLGAGFDFIFDQYNKVAVTAEVTKLLVPTPPIYGFVDSDEDGEYDEGSEEVVIYKGKDPNVSFLSGMFQSFGDAPDGFSEELKEFTWSLGAEYVYQDSFAFRAGYFNESEEKGARKFLALGAGFKANVVNIDLSYLFSASKVQSPLENTLRFSLTFNIGAGEYNEY
>CP022985.1|AXP79956.1|906882_907365_-|Cytidine-deaminase
MKEVKIASTLYVFENMEELPKEAFFLMQKAFEARDKAYAPYSNFHVGAAILLDNGEIITGSNQENASYPSGLCAERTAIYYAGSQYPNTKIVRMAISASSKNKPTLGPIPPCGACRQAIAEYEIKQKSPIEIYFMGETGNVAKSTSLANLLPLVFDKSVL
>CP022985.1|AXP79955.1|905671_906670_-|Acetoin:2-2C6-dichlorophenolindophenol-oxidoreductase-subunit-alpha
MQKITKEVYLKWYEDMLFWRKFEDKLAAVYIQQKVRGFLHLYNGQEAVLAGALHAMDLTKDKMITAYRNHVQPIGMGVDPRRVMAELYGKVTGTSKGMGGSMHIFSKEHRFYGGHGIVGGQIPLGAGIAFGDKYHGVDGVTLCCFGDGAARQGSLHETFNLAMLWNLPVVFVCENNGYAMGTSVERTANHTEIWKLGLGYNMPCGPVDGMNPIKVAEAFDEAIQRARKGGGPTFLELKTYRYRGHSMSDAQHYRTKDEVEEYKKIDPITQVKDIILEKKYATEDDIKVIDKRVKDLVAECEKFAEESPYPETQQLYDMVYEQEDYPFIKHKI
>CP022985.1|AXP79954.1|904000_905668_-|Dihydrolipoyllysine-residue-acetyltransferase-component-of-pyruvate-dehydrogenase-complex
MAEIINMPRLSDTMEEGTVATWLKKVGDKISEGDILAEIETDKATMEFESFHEGTLLHIGVQEGETTKVDELLAIIGEAGEDISGLLKGGSASKSDAAPETKEVTKEKETNSEPASETDSEPVEEKAEAPASEELPEGVVVVTMPRLSDTMEEGTVATWLKKEGDKVSEGDILAEIETDKATMEFESFQSGTLLHIGLQEGESAKVDSLLAIIGPAGTDVSGVAANFSTSKPAAKKEEAPKQEKKEEAPEEAKAEAPKKEAKAAKPVATTSTNGRLFVSPLAKKIAEEKGINLSQVKGSGENGRIVKSDIENYTPSAAASLGKFVPVGQEDFEEVPNSQMRKAIAKALTNSKFSAPHYYLNVEFDMENAIAFRTQFNTIPDTKISYNDIVVKACALALKQHPQVNSQWFADKMRLNNHVHIGVAVAVPDGLVVPVVKFANEQSLPQIGAAVKDLAGKARNKKLTPQEMEGSTFTVSNLGMFGIDTFTSIINQPNSAILSVGNIVEKPVVKNGQIVVGNTMKLSLACDHRTIDGATGAQFLQTLKGYIENPVTMLV
>CP022985.1|AXP79953.1|903521_903914_+|hypothetical-protein
MKTLKIFSVFILALAFINCANNEKSVADSLRDETTTQNQNMYVIEREIPGAGNLTSEELKAISQSSCGVLEKMGSEIKWLHSYVTGDKIYCVYTAPNEEMVLEHAKQGGFPANSVAKVATVIDPSTADDK
>CP022985.1|AXP79952.1|903111_903210_+|hypothetical-protein
MAVLEHAKQDGFSANSVAKVTTVIDPSTADDR
>CP022985.1|AXP79951.1|902635_903100_+|Cupin-domain-protein
METTKFKFIYSCLIVFVLNGLSLCAQTAATVNSEMSIANTIDDADLIWHKAPDFFPNCSFTILNGDISKPNLDLFFKIEPNTDVISHTHNSPERMVLITGELEVTYEGEAPRIIKAGSYLYGPAGKPHKAKCLDSGPCVLFIALVAPFDANPTE
>CP022985.1|AXP79950.1|901205_902594_+|6-hydroxy-D-nicotine-oxidase
MKNQVKNLDPSLIEAFSSKLRGKIIMPKDVNYDETRKVYNGMINKHPGMFVMCVDVADVMASVNFGRENNLLIAVRGGGHNGGGLGLCDDGLVIDLSGIKFIRIDTSDNTVRVGGGNLWGEVDHATHPFGLAVPAGIISTTGVGGLTLGGGIGHLSRKYGLTIDNLLEADMVLADGSFVTVNKNQNADLFWAIRGGGGNFGIVTSFKFQAHKVKNVIGGPTLWPIERTEEIMAWYHEFINNAPDELNGFIATMIIPGSPFPDFLHGNQYCGIVWCYTGSQEAFNKLIKPAMDLNPVFEHVGEMPYPSIQTLFDGLMPPGLQWYWRADFFNELGPEVSAQHLKFGSSIPTPLSQMHLYPISGAASRIGAEETPWAYRDAKYAGVIVGVSPEPKDADKITNWCKEYWEALHPYSSGGAYSNFMMDEGQERIKASYRHNYERLSKIKRKYDTNNLFNVNQNIKPA
>CP022985.1|AXP79949.1|900814_901189_+|Group-1-truncated-hemoglobin-GlbN
MTKTLFERLGGRNGISNIVDDTVENHMNNPEVNARFLPFKDRPEHLAIIKQHTIDFFSAGSGGPATYKGKDMVTAHTGMNISPTEYMHVVDDIFAALDKNGIDEDSKKDVLSVLWSLKGMIISK
>CP022985.1|AXP79948.1|899605_900712_+|Regulatory-protein-PchR
MPIYMDRHDIPEEITAEHVALMHQEDLKVQHLYGCKGMTYWCDEDRRTAFCLIEAPNEKAIEDMHNNAHGEVPHRIIEVNKTIVESFLGRIEDPEKSQNTELNIINDPAFRVIMLIETSDYLHRLEGNQFSLFTQKFHNSVTKSFKQFKGCIVKQNNSSYLVSFVSVSDAILCALKIQYNFKYITTKYDTSMRTLNMGISSGVPVTNKDSFFEETITLATRLCEIVNDQIVITSEIKSLYESENRNQFINKEHIRSINKNEEKFLTDLMDFVATIWNKPDFNVNDFSTTLGYSKSQLNRKLKSLTGKSPNNFIVDYKLQKALKALHDQQGNISEIAFETGFNSPAYFSTCFKNKFGMLPSQYLQQHVV
>CP022985.1|AXP79959.1|913197_914886_+|Serine/threonine-protein-kinase-pkn1
MKKVVAFKVLLVLALTIAATGCKKSSSSKNSSRATGWQINSREGGFQYNTDFKEQETSPGLVFVEGGTFTKGRVQDDVMHDWNNTPNQQHVQSFYMDETEVTNAMYMEYLDWIKRVYPPSDENFRAIYNGALPDTLVWRNRLGYNEVMTDNYLRHPGYGEYPVVGVSWIQAVEFANWRSDRVNEYNLEQAGYLKRDAKIVDVNAESTFNTDTYINAPSLTYGGNEEIINPERGNKRFVRTDADGNESNIYATRETGLITPKYRLPTETEWEYAALGLSEIRSYNLYRGRKKYPWDGQYTRNDSRKYRGDQLANFKQGKGDYGGIAGWSDDGADITNAVKSYEPNDFGLYDMAGNVAEWVADVYRPIIDDEFNDFNYYRGNVYTKNAINEDGTVKVVTVDDIVYDTLSNGKVVARNLPGEILQVPVDENETYLRTNFDKSNQINFRDGDKRSSRNFESFNEEDGNGDTKVSQTSKMYNSPKNIISRDSLGNIIREYDKSNTRTSLINDEVRVYKGGSWKDREYWLDPAQRRYFPQDMATDYIGFRCAMSRVGSKSKEKNKTKN
>CP022985.1|AXP79960.1|914977_916258_+|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D--alanine-ligase
MKIQQLHTLFLECYSACTDTRKIKENDMFFALKGDNFNGNTYTEQAIQSGAKYCIVDEAEFNTSSKTILVENVLETLQTLAAFHRTFLNIPIIALTGSNGKTTTKELINATLSQKYRTTATVGNLNNHIGVPLTLLSMTKSTEIGIVEMGANHLKEIEFLCNITKPDYGYITNFGKAHLEGFGSVEGVIKAKSELYNFLIENNKTIFVNGNDAIQLEKTKHSNAYIFGNNDGFDIQISFIEAQPNVCVSYNDLTIQSHLIGEYNFNNIAAAIAIANYFKVEDKAIKSAIENYMPNNNRSQVLLKASNKIILDAYNANPTSMQAALLNFEKLNDTSKIAILGDMFELGQDAAIEHQNIVELLETLNYDKTILIGENFYKTVTKSKKIIQFKSFEAFKSDFVITQIKNTALLIKGSRGMALERILDIL
>CP022985.1|AXP79961.1|916555_917773_-|Bifunctional-protein-FolC
MAYQDTLHWMFSQLPMYQRQGQSAFRKDLSNTLKLADRLNHPERHFKTIHVAGTNGKGSVSHMLASILQEAGYKVGLYTSPHLKDFRERIKINGNLVSKQYVTSFINKNKPFFQENSLSFFEMTVGMAFEYFSKQKVDIAVIEVGLGGRLDSTNIITPEVSVITNIGLDHTQFLGTTLEAIAYEKGGIIKPNVPVVIGETQKETAPVFIELANKNNAKILFADAEVIETFTSDLTGIYQSKNIITVIQAIKELQHKGYNISHQNIKEGLLHVVKNTGFMGRWQVLRTHPKVVCDTGHNRDGLSYVMKQLSNEVFDTLHIVFGVVNDKDLTSIIDLLPKNAIYYFCKPDIPRGLDAKELKSILNGYGLKGEAYNSVNEAYNNALDKASSNDFIFIGGSTFVVAEII
>CP022985.1|AXP79962.1|917775_918624_-|hypothetical-protein
MKYFETKHERDSAKLTALITVILLLLLFVVGAPYMDPPEEYGISVNFGTTDFGSGTVQPLKPIKSEPLDINRPTEPEVSKVEPTKAAETKEEVLTADNSEEIAIKKQKEAEAKAKAIADAKAKAEAERIAKEKRELEEKKKKLDALIGGVSKSEGTATGGEGDDNKAGDKGQLDGDPYAPSYFGSGGSGSGGVGYGLNGRGSASYQTLKQDCNESGMVIVKIIVNRNGSVIEAEPGVRGTTNTAACLLEPAKKIALSHKWRPDPNAPTKQIGFVKVNFKLGQ
>CP022985.1|AXP79963.1|918686_919079_-|Biopolymer-transport-protein-ExbD
MNIRGRNKVSPEFNMSSMTDIVFLLLIFFMIASTLVSTSAIDILLPKASGKTENKKSVAVSIKADLTYYIDQRRIGESVLETELLAALASEEKPTIVLRAEKSVPVENVVKVMDIANRNKFKVILAVKPN
>CP022985.1|AXP79964.1|919080_919782_-|colicin-uptake-protein-TolQ
MLNTLLQNTQEGAELLTDAEPVEKTLSIIELISSGGLAGQLIIAVLFLMLVLAIYIYFERLFAIKAASKIDANFMNQIKDHVTHGKVDSAQILCAQVNSPVSRLIGKGISRIGKPLADINTALENAGRLEIYGLEKNVSILATISGAGPMIGFLGTVIGMILAIFELANAGGTIQMDVLASGLYTAMTTTVAGLIVGIVAFMAYNHLVVKTDKVVYQMEANSLEFLDHLNEPS
>CP022985.1|AXP79965.1|919983_921381_-|Na(+)/H(+)-antiporter-NhaD
MEAAIILVFVIGYLAITLEHNLKVDKLIPALVMMAISWALISLGLESFPNWFDSAKHSLVEGFAGFAPEEKMHLMEETLLHHLGKTAEILVFLLGAMTIVEIIDYFDGFSTIKDFVKTKKKTKILWLFGFLAFILSAIIDNLTATIVLISILQKIVKDRDIRIWYAGLIIIAANAGGAWSPIGDVTTTMLWIGKKVSTGHLVGYLFIPSFLCMAVPTFIASFLPVFKGNLEIEEAEEETTKSRFSSVMLYLGLGAIVFVPIFKMVTHLPPYVGMMLSLGVVAVFAEMYSSSKFSISDFNRAEESEEHAHYSPVHHSLSKIELPSILFFLGILMAVAALESLGILFEFAASLKEGMPLLGTELHDSGVSDLVMLLLGVGSAVIDNVPLVAASLGMFSEPMDNELWHFVAFSAGTGGSMLIIGSAAGVVAMGMEKIDFFWYLKKISWLAAIGFLVGSAAFMVTRTLF
>CP022985.1|AXP79966.1|921396_922623_-|NADP-specific-glutamate-dehydrogenase
MKELLKKYEDKAPEIIFNWKDSETEAEGWVVINSLRGGAAGGGTRMRKGLDMNEVLSLAKTMEIKFTVSGPAIGGAKSGINFDPKDPRKKGVLERWYKVVSPLLKSYYGTGGDLNVDETHEVIPITEESGVWHPQEGVFNGHFKPTEADKINRIGQLRQGVIKVIENPVYSPNVSRKYTVADMITGFGVAEAVKHYYNTYGGSVKGKRAVIQGFGNVGAAAAFYLSQMGAKVVGIIDIAGGLINEKGFTFEEITNLFLAKAGNTLVSDNLIPFEEINQKIWSIKTEIFAPCAASRLITIHQIDEMIDSGLEVISCGANVPFADKEIFFGNIMEHTDYRVSLIPDFISNCGMARVFAYFMERRVQMTDEAIFNDTSNKIKEAIENVYNKNQSKTGISATAFEIALSQLI
>CP022985.1|AXP79967.1|922956_924021_-|Anhydro-N-acetylmuramic-acid-kinase
MMKDEYKVIGVMSGTSLDGIDFVYATFQFDGTWHFKIIYSETIAYNSEWVENLKGLVSYSLEGLREMDTNYTNYLFMRIKAFINKFEIKDIDAICSHGHTALHQPEKGITYQIGNMPHLAVLLGQTVVCDFRVQDVALGGQGAPLVPIGDKLLFSEYDFCLNLGGFANISTDTGVDRIAYDVCPVNIVLNRYVEQLGLHYDDEGKIASTGTINNELLEKLNSLEFYKANSPKSLGLEWVDKNIFPLIDSFQLEIKDILKTFVEHIAIQLASEINKKSDASVLATGGGVYNTYLINRLEAYSKNEIMIPSKAIVEFKEALIFGFLGVLRLRNEVNSLKSVTGASQNHSSGKIYLP
>CP022985.1|AXP79968.1|924115_925258_+|Acyl-CoA-dehydrogenase
MNFNLSEEHIMIRDAARDFAQTELLPGVIERDENQHFPKELVKKMGDLGFLGVMVDPKYGGSGMDAISYVLIMEELSKIDASASVIVSVNNSLVCYGIETFGTEAQKQKYLTKLATGEFIGAFCLSEPEAGSDATSQKTSAIDKGDHYLLNGTKNWITNGGRADVYLVIAQTDKDKGSHGINTFIVEKGTEGFHVGPKENKLGIRGSDTHTLQFNDVKVPKENRIGEDGSGFRFAMKTLSGGRIGIASQALGIASGAYELALKYSKERKAFGTEICNHQAIAFKLADMHTEIEAARHLVMKAAWDKDQDNNYDVSSAMAKLYASKVAMEHTVEAVQIHGGNGFVKDYHVERLMRDAKITQIYEGTSEIQKIVISRSLIKQ

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Crispr_ID: CP022985_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022985_3

2437442-2437539

Orphan

Consensus_repeat	Method
TCAAGAACCAAGAGAGCAGAATA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022985_3

>merge|CP022985|3|2437442-2437539|CRISPRCasFinder
TCAAGAACCAAGAGTCAAGAACCAAGAGAGCAGAATATGTCTTTTCTCTTTTTCTCTACTCTTTTATCTTAAAAATAAAGAATGAAGAACCAAGAATA

>CP022985|3|3|2437442-2437539|CRISPRCasFinder
TCAAGAACCAAGAGTCAAGAACC	AAGAGAGCAGAATATGTCTTTTCTCTTTTTCTCTACTCTTTTATCTTAAAAA
TAAAGAATGAAGAACCAAGAATA

Protein	Signature genes	Signature genes Name	Protein_function
CP022985.1\|AXP81174.1\|2428763_2431262_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372685
CP022985.1\|AXP81178.1\|2435666_2437400_+\|Acetolactate-synthase-large-subunit	unknown	unknown	gnl\|CDD\|272915
CP022985.1\|AXP81172.1\|2426813_2427560_-\|Electron-transfer-flavoprotein-subunit-beta	unknown	unknown	gnl\|CDD\|238847
CP022985.1\|AXP81188.1\|2448397_2449594_+\|Gamma-glutamyl-phosphate-reductase	unknown	unknown	gnl\|CDD\|234685
CP022985.1\|AXP81184.1\|2444081_2445257_+\|Argininosuccinate-synthase	unknown	unknown	gnl\|CDD\|238957
CP022985.1\|AXP81175.1\|2431258_2431852_-\|HPP-family-protein	unknown	unknown	gnl\|CDD\|377434
CP022985.1\|AXP81181.1\|2439699_2440965_+\|L-threonine-dehydratase-biosynthetic-IlvA	unknown	unknown	gnl\|CDD\|236318
CP022985.1\|AXP81182.1\|2441332_2442925_+\|NADP-dependent-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|143401
CP022985.1\|AXP81187.1\|2447145_2448291_+\|Acetylornithine-aminotransferase	unknown	unknown	gnl\|CDD\|227325
CP022985.1\|AXP81170.1\|2424825_2425467_-\|UvrB/uvrC-motif-protein	unknown	unknown	gnl\|CDD\|376830
CP022985.1\|AXP81183.1\|2443421_2444039_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173926
CP022985.1\|AXP81186.1\|2446349_2447144_+\|Pyrroline-5-carboxylate-reductase	unknown	unknown	gnl\|CDD\|223422
CP022985.1\|AXP81173.1\|2427719_2428697_+\|2-oxoisovalerate-dehydrogenase-subunit-beta	unknown	unknown	gnl\|CDD\|223101
CP022985.1\|AXP81169.1\|2423277_2424801_-\|Nucleoside-permease-NupX	unknown	unknown	gnl\|CDD\|224883
CP022985.1\|AXP81185.1\|2445260_2446238_+\|N-acetyl-gamma-glutamyl-phosphate-reductase	unknown	unknown	gnl\|CDD\|234761
CP022985.1\|AXP81179.1\|2437601_2438135_+\|Putative-acetolactate-synthase-small-subunit	unknown	unknown	gnl\|CDD\|183365
CP022985.1\|AXP81176.1\|2431960_2433214_-\|S-adenosylmethionine-synthase	unknown	unknown	gnl\|CDD\|235374
CP022985.1\|AXP81177.1\|2433871_2435557_+\|Dihydroxy-acid-dehydratase	unknown	unknown	gnl\|CDD\|234861
CP022985.1\|AXP81171.1\|2425732_2426692_-\|Acryloyl-CoA-reductase-electron-transfer-subunit-beta	unknown	unknown	gnl\|CDD\|224936
CP022985.1\|AXP81180.1\|2438150_2439626_+\|Ketol-acid-reductoisomerase	unknown	unknown	gnl\|CDD\|235368

Protein	Function_ID	Function_description	E-value
CP022985.1\|AXP81174.1\|2428763_2431262_+\|hypothetical-protein	gnl\|CDD\|372685	pfam13715, CarbopepD_reg_2, CarboxypepD_reg-like domain. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.	1.01893e-16
CP022985.1\|AXP81178.1\|2435666_2437400_+\|Acetolactate-synthase-large-subunit	gnl\|CDD\|272915	TIGR00118, Probable_acetolactate_synthase_large_subunit, acetolactate synthase, large subunit, biosynthetic type. Two groups of proteins form acetolactate from two molecules of pyruvate. The type of acetolactate synthase described in this model also catalyzes the formation of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, an early step in the branched chain amino acid biosynthesis; it is therefore also termed acetohydroxyacid synthase. In bacteria, this catalytic chain is associated with a smaller regulatory chain in an alpha2/beta2 heterotetramer. Acetolactate synthase is a thiamine pyrophosphate enzyme. In this type, FAD and Mg++ are also found. Several isozymes of this enzyme are found in E. coli K12, one of which contains a frameshift in the large subunit gene and is not expressed. [Amino acid biosynthesis, Pyruvate family].	0
CP022985.1\|AXP81172.1\|2426813_2427560_-\|Electron-transfer-flavoprotein-subunit-beta	gnl\|CDD\|238847	cd01714, ETF_beta, The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer . A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation. The beta subunit protein is distantly related to and forms a heterodimer with the alpha subunit.	4.15576e-63
CP022985.1\|AXP81188.1\|2448397_2449594_+\|Gamma-glutamyl-phosphate-reductase	gnl\|CDD\|234685	PRK00197, proA, gamma-glutamyl phosphate reductase; Provisional.	5.68162e-153
CP022985.1\|AXP81184.1\|2444081_2445257_+\|Argininosuccinate-synthase	gnl\|CDD\|238957	cd01999, Argininosuccinate_Synthase, Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In humans, a defect in the AS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. AS is a homotetrameric enzyme of chains of about 400 amino-acid residues. An arginine seems to be important for the enzyme's catalytic mechanism. The sequences of AS from various prokaryotes, archaebacteria and eukaryotes show significant similarity.	9.89251e-140
CP022985.1\|AXP81175.1\|2431258_2431852_-\|HPP-family-protein	gnl\|CDD\|377434	pfam04982, HPP, HPP family. These proteins are integral membrane proteins with four transmembrane spanning helices. The most conserved region of the alignment is a motif HPP. The function of these proteins is uncertain but they may be transporters.	4.47646e-56
CP022985.1\|AXP81181.1\|2439699_2440965_+\|L-threonine-dehydratase-biosynthetic-IlvA	gnl\|CDD\|236318	PRK08639, PRK08639, threonine dehydratase; Validated.	0
CP022985.1\|AXP81182.1\|2441332_2442925_+\|NADP-dependent-glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|143401	cd07082, ALDH_F11_NP-GAPDH, NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11. NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase (NP-GAPDH, EC=1.2.1.9) catalyzes the irreversible oxidation of glyceraldehyde 3-phosphate to 3-phosphoglycerate generating NADPH for biosynthetic reactions. This CD also includes the Arabidopsis thaliana osmotic-stress-inducible ALDH family 11, ALDH11A3 and similar sequences. In autotrophic eukaryotes, NP-GAPDH generates NADPH for biosynthetic processes from photosynthetic glyceraldehyde-3-phosphate exported from the chloroplast and catalyzes one of the classic glycolytic bypass reactions unique to plants.	0
CP022985.1\|AXP81187.1\|2447145_2448291_+\|Acetylornithine-aminotransferase	gnl\|CDD\|227325	COG4992, ArgD, Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism].	2.76262e-125
CP022985.1\|AXP81170.1\|2424825_2425467_-\|UvrB/uvrC-motif-protein	gnl\|CDD\|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	6.61736e-59
CP022985.1\|AXP81183.1\|2443421_2444039_+\|hypothetical-protein	gnl\|CDD\|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	9.54968e-05
CP022985.1\|AXP81186.1\|2446349_2447144_+\|Pyrroline-5-carboxylate-reductase	gnl\|CDD\|223422	COG0345, ProC, Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism].	3.3381e-69
CP022985.1\|AXP81173.1\|2427719_2428697_+\|2-oxoisovalerate-dehydrogenase-subunit-beta	gnl\|CDD\|223101	COG0022, AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion].	0
CP022985.1\|AXP81169.1\|2423277_2424801_-\|Nucleoside-permease-NupX	gnl\|CDD\|224883	COG1972, NupC, Nucleoside permease [Nucleotide transport and metabolism].	3.3014e-126
CP022985.1\|AXP81185.1\|2445260_2446238_+\|N-acetyl-gamma-glutamyl-phosphate-reductase	gnl\|CDD\|234761	PRK00436, argC, N-acetyl-gamma-glutamyl-phosphate reductase; Validated.	7.13876e-153
CP022985.1\|AXP81179.1\|2437601_2438135_+\|Putative-acetolactate-synthase-small-subunit	gnl\|CDD\|183365	PRK11895, ilvH, acetolactate synthase 3 regulatory subunit; Reviewed.	3.22875e-22
CP022985.1\|AXP81176.1\|2431960_2433214_-\|S-adenosylmethionine-synthase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
CP022985.1\|AXP81177.1\|2433871_2435557_+\|Dihydroxy-acid-dehydratase	gnl\|CDD\|234861	PRK00911, PRK00911, dihydroxy-acid dehydratase; Provisional.	0
CP022985.1\|AXP81171.1\|2425732_2426692_-\|Acryloyl-CoA-reductase-electron-transfer-subunit-beta	gnl\|CDD\|224936	COG2025, FixB, Electron transfer flavoprotein, alpha subunit [Energy production and conversion].	2.11043e-86
CP022985.1\|AXP81180.1\|2438150_2439626_+\|Ketol-acid-reductoisomerase	gnl\|CDD\|235368	PRK05225, PRK05225, ketol-acid reductoisomerase; Validated.	0

>CP022985.1|AXP81178.1|2435666_2437400_+|Acetolactate-synthase-large-subunit
MNTQTANKKQEVAQETIRITGSEAIIRCLIAEGVDILYGYPGGAIMPVYDELYKFRDQIHHVLTRHEQGAAHAAQGFARISGRVGVAMATSGPGATNLITGIADAQIDSTPLVCITGQVFSHLLGTDAFQETDIIGISTPVTKWNHQITKSSEIPEVLAKAFYIAKSGRPGPVLIDITKDAQVGELDFKYEKCTGVRSYTPVPKTNPESLSAAAELINSAKKPFIVWGQGVILGQAENELKAIIEKAGIPAAWTILGASALPTSHPLNVGMVGMHGNYAPNMLTNECDVLIAIGMRFDDRVTGSLNTYAKQAKIIHFDIDPAEIDKNVKTDVAVLGDSKDSLARLLPLLNENKHTTWLQKFKDLYAIEFEKVIKDDISPVKEGLTMGEVLKQINIETKGNAAIVSDVGQHQMIACRYSEFNVTKSNITSGGLGTMGFALPAAIGAKMAAPDREVVAIIGDGGYQMNIQELGTIFQQKVPVKIVVLNNEFLGMVRQWQQLFFDKRYASTEMTNPDFVTIAKGYYIEGKRVKKREELAAAIKEMIASKESYFLEVCVEKEDNVFPMIPSGASVSDIRLS
>CP022985.1|AXP81177.1|2433871_2435557_+|Dihydroxy-acid-dehydratase
MKELNKYSSRLTQDVSQPASQAMLYAVGLTDEDMQKAQVGIASTGYDGNPCNMHLNNLASEVKIECKIAGLVGLGFNTIGVSDGISMGTSGMNYSLASRDIIADSIETVMHAQSYDALISVVGCDKNMPGAVIAMLRLNRPSIMMYGGTIASGKYKGRKLNIVSAFEALGQKVAGEIDEEEYREIIKSAIPGAGACGGMYTANTMASAIECMGFALPYNSSIPAENPNKLSESERTAIAIKNLLELDLKPLDIISKKSIENAIALVNALGGSTNAVLHFLAIAHAADIEFTLEDFQRVSDRTPLIADLKPSGKYLMEDVHGIGGTPAVMKYLLDNGYLHGDCLTVTGKTLAENLKDVEPLKFENDQDVIYPKDKALKSSGNLQILYGNLAEEGAVAKISGNEGLLFEGKAVVYDGEQAANTGISNGEVEKGDVVVIRYVGPKGGPGMPEMLKPTSLIMGAGLGKSVALITDGRFSGGTHGFVVGHITPEAQEGGTIGLLKTGDSIRISAEDNSINVLLSDEELAERRSQWVAPELKHKKGILYKYARSVSSASKGCITDAF
>CP022985.1|AXP81176.1|2431960_2433214_-|S-adenosylmethionine-synthase
MAYLFTSESVSEGHPDKVADQISDALIDNFLAFDKDSKVACETLVTTGQVILAGEVKSHTYLDVQKIARDTINSIGYTKGEYMFDGNSCGVLSAIHEQSDDINRGVDRATKEQQGAGDQGMMFGYATNETENFMPLALDLSHRILKELADLRRESKDITYLRPDSKSQVTIEYSDDNIPQRIDAIVISTQHDDFADDDTMLAKIRKDIVDILIPRVVSKLPESIQVLFNSDIKYHINPTGKFVIGGPHGDTGLTGRKIIVDTYGGKGAHGGGAFSGKDPSKVDRSAAYATRHIAKNLVAAGVADEVLVQVSYAIGVVEPMGIFINTYGTCPFNMTDGEIAEIVSNIFDMRPYAIEERLKLRAPIYSETAAYGHMGRKNETVTKTFSQPNGENITLDVELFTWEKLDYVDKVKEAFGL
>CP022985.1|AXP81175.1|2431258_2431852_-|HPP-family-protein
MIKKKISRTIRISKYVIYKETLIDFKEHFWSFIGAFFGIGLIAFMQSLFLPKLENTFLVGSFGASSVLIYGAIESPLSQPRNLIGGHLISAIIGVTVFKLFPDTIWVTAPLAVSLSIVFMQFTKTLHPPGGATALIAVIGTEKIKSLGYMYVFSPVLTGTLILFIVALVFNNTTAHRSYPTNSFIKRFLKRKNLNSL
>CP022985.1|AXP81174.1|2428763_2431262_+|hypothetical-protein
MNPKLLFTFFLFGIISTSTFAQTKVSGYVLDEDNQPISFANVIFKGSTQGTITDENGKFYMESTDTWNALIVSFLGYETLDIPLTKKVNYELKFILKEAAAELDQVFIVAGKQSKKNNPAIDLLRKIWEHKRKNGLKHFKQYEYNKYEKVEFDINTIDSALIKSKLFRGMEFVFNEVDTSNVTGKTYLPIFINEAVSTVYGDNLLNKEKEVLKGNKNSGFSDNQIIIDFVDDLYSDYDVYDNYLRFFDKSFVSPLSRTGINTYNYVLKDSAFIDNKWCYNIIYYPRRKNELTFKGDFWVADTTYAIKEIKLQASKSANINWVKEIYIEQEFEVLNDSIFLVKRDYMMSDFAFNKKEKSRGVYGKRTTLYDNYKFDIEKNKKFYETEVYNYDKDVYDRDDSFWSENRLEALNKDEKGVYKMLDTLKTVKKFKRLYNLGSILASGYIEFNELPLDYGPIFSTFGFNEVEGMRLRAGGRTYFGKNDLWRLEGFLAYGFKDGKFKYGISGKWLLDKKNRLIISGGNRRDVEQTGASLTTSTDVLGRSLASSAVIGTGSNDKLTSINLTSLAVELEPWRNLVFRFGANYRTLASASPTFSLDYNTPTGIESEIKQYESTFSVSYFPKRKMTGFGVERLHANDDYASIFAQISRGDKSLFSSDFNYTKVQFSYIQPMQVGGFGRLTTTIEAGKTFGEVPLGLLSPIPGNQSYFSIYNTFSQLDFYEFVSDTYTSLQLEHNFNGRFFSRIPFLRKLNLREIVGIRGVWGEVSQENKDLNASSLIYRAPSDKMYYEYSFGVGNIFKVFRIDFNFRGNYLDEVENPNARKFGVTGSFGFHF
>CP022985.1|AXP81173.1|2427719_2428697_+|2-oxoisovalerate-dehydrogenase-subunit-beta
MKTIQFREAICEAMSEEMRRDESIYLMGEEVAEYNGAYKASKGMLDEFGPKRVIDTPIAELGFAGIAVGSTMTGNRPIVEYMTFNFSLVGIDQIINNAAKIRQMSGGQFKCPIVFRGPTASAGQLGATHSQAFESWFANTPGLKVVVPSNPYDAKGLLKAAIRDDDPVIFMESEQMYGDKGEVPEGEYILPLGVADIKREGTDVTIVSFGKIIKEAYKAADELEKEGISCEIIDLRTVRPLDKETILKSVKKTNRLVILEEAWPFGNVSTEITYIVQSEAFDYLDAPVVKINTADTPAPYSPVLLAEWLPDSKEVIKAVKKVLYI
>CP022985.1|AXP81172.1|2426813_2427560_-|Electron-transfer-flavoprotein-subunit-beta
MKILVCISHVPDTTSKINFTEGDTKFDTNGVQFVINPNDEFGLTRAMWFKEKQGAHVTVVNVGGAETEPTLRKALAIGADGAIRVNTAATDGFSVAKQLANVVKNGGYDLVIAGRESIDYNGGMVPGMIAGLIDANFVNNCISLEIDGDTAKAIREIDGGKETLSTSLPLVIGGQKGLVQESDLRIPNMRGIMMARQKPLTILEPVDANNETTSVKFEKPAPKGAVKLVSPDNLDELINLLHNEAKVI
>CP022985.1|AXP81171.1|2425732_2426692_-|Acryloyl-CoA-reductase-electron-transfer-subunit-beta
MSVLVYTESEQGKFKKTAFEVASYAKAVADQLGTTVTAITINANDTSELGNYGVDKVLNVSNTQLDMFNAKGYAEAIQQAAEQEASKIIILSSSANSKYLAPLLAVRLNAGYASNVINAPSSTSPFTVKRTAFTNKAFEMTTINTDVKIVGVSNNSFGLVEKSGDASAEDFSPVISDLGVKVESIDKASNKVSIADAEIVVSGGRGLKGPENWGMVEELASVLGAATACSKPVSDLGWRPHGEHVGQTGKPVAANLYIAIGISGAIQHLAGINASKVKVVINSDADAPFFKAADYGVVGDAFTVVPELIEKLKAFKAQQ
>CP022985.1|AXP81170.1|2424825_2425467_-|UvrB/uvrC-motif-protein
MRFHKFMSLVRLNIKGISYSQTQNGAYALILNEVDGDRKLPIVIGAFEAQSIAIALEKEIRPPRPLTHDLFKNFADRFDIVVKQVIIHKLVDGVFYSSLICERDKIEEIIDARTSDAIALALRFDAPIFTYKNILDKAGIYLKVNPKKENEEEDAQDSVLMDELIANELEPNAPRENFKGKTLQELHILLDEAVANEDYERAAHIRDEISKRE
>CP022985.1|AXP81169.1|2423277_2424801_-|Nucleoside-permease-NupX
MKKIFLSIALILLVFTSSIAAQDKDKTTFQDTVLNTKTAVLSSQHHTVDSLKVNTPETQTGTTTLKTAIIIPSQGFSTSSLWRGALGMVSLIFIAFLFSSNRKAINWKIVGIGLTFQLLIAIGVLKVEFIKSIFEFVGGLFVSVLDFTRAGSKFLFEGLVVDMDTFGFIFAFQVLPTIIFFSALTSVLFYLGIIQKVVKAMAWLLSKALKVSGAESLSVAGNIFLGQTEAPLLIKAYLEKMNKSEMLLVMIGGMATAAGAVLAAYIGFLGGDDPLLRLFYAKHLLAASVMAAPGAIIVSKILYPQTEDINTDVAVSQEKIGSNFLDAIANGTTEGLKLAVNVGAMLLVFVAFIAMFNGILGWIGDISTLNEWVVNNTGYQNLSIELILGYAFAPLMWLIGVAKEDMMMMGQLLGIKIAASEFIGYIQLRDLKDMANATHLNYEKSVIMATYMLCGFANFASIGIQIGGIGSLAPGQRKTLSQFGMKALLGGTIASLVSATIAGMIIG
>CP022985.1|AXP81179.1|2437601_2438135_+|Putative-acetolactate-synthase-small-subunit
MNEEIKTFTISIYTENNIGLLNRISAIFQRRHINIESLTTSQSEIEGVNRFVIVVNITEPQAKKIIGQFEKQVEVIKAYYHKDEETIYTESCMFKIKSALLFEEPQIQNIIKESNARIVTVNKEFFVLEKSGRRNEIESLRRDLNVFGIMQFVRAGRIAVTKDEMKVTEVLLAFNNQ
>CP022985.1|AXP81180.1|2438150_2439626_+|Ketol-acid-reductoisomerase
MGNYFNTLSLRDKLTQLSKCRFMDSSEFEDGVNALKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRAEAIAEKRKSFVNASENGFNVGTYEELIPTADLVLNLTPDKQHTSVVKAVMPLMKKGATLSYSHGFNIVEEGTQIREDLTVIMVAPKCPGTEVREEYKRGFGVPTLIAVHEENDPEGKGWAQAKAYAAATGGDRAGVLASSFVAEVKSDLMGEQTILCGLLQTGSILCFDKMIEKGIDAGYASKLIQYGWETVTEGLKYGGITNMMDRLSNPAKIKAFELSEELKDIMRPLFQKHMDDIMEGRFSSGMMADWANNDKDLLGWRAATAQTAFEKTPAGNVEISEQEYYDNGVLMVAMVRAGVELAFEAMTDSGIIDASAYYESLHETPLIANTIARRKLYEMNSVISDTAEYGCYLFDHACKPLLADFMKKIDTDVIGKAYAKDNGKAVDNAKLIAVNKALREHPVEKIGSFLRASMTAMKPIV
>CP022985.1|AXP81181.1|2439699_2440965_+|L-threonine-dehydratase-biosynthetic-IlvA
MNKEKYTYFPSIKDVKVAADIIQKVSAVTPLSPSFRYSKQFEATILLKREDLQQVRSYKIRGAYNKISSLTAEESQKGVVCASAGNHAQGVALSCKLLKIKGSIYMPAPTPNQKVEQVKMFGEDFIEIKLIGDTYDDAYHAAMLECEQQQKIFIHPFDDKKVIEGQATIALEILEQTNVPIDYVFVAVGGGGLAAGLSTVFKELSPSTKIIGVEPDGAPSMLTSIKNNRNTTLEHIERFIDGAAVKRVGDLTFNICKENLHDMITVPEGKVCETILELYNKDAIVVEPAGALSIAALDFYAEDIKGKHVVCVVSGSNNDITRTAEIKERALLYANLKHYFIVLFPQRAGALKEFVVDILGPNDDITHFQYTKKTNRENGSAVVGIQLKSAADLEPLITKMKQRNFYGDYLNNKPDLFQFLV
>CP022985.1|AXP81182.1|2441332_2442925_+|NADP-dependent-glyceraldehyde-3-phosphate-dehydrogenase
MSTTLFEIPELYKIHTLLHQTTYLTNGELIEWKGETAEVYSTISSTPDYKPTLLGTIPQLGEKEALEVLNSALTAYDKGQGLWPTMKVIDRIACMEKFVEQMKTKRDVIVKLLMWEIGKNLPDSQKEFDRTVDYIYDTIEAYKQIDRDSAKFEKNDGVYAHIRRGPLGVVLCLGPYNYPLNETFTLLIPALIMGNPVIFKPAKLGVLLISPLLEAFQNSFPKGVVNVIYGRGRVLATPIMKSGKIDVLALIGNSKSANALQAQHPKGNRLRMVLGLEAKNPAIVLPDADLDLTVEECIAGTLSFNGQRCTALKVVYVHDSVVDEFNKRFTAKVDALKFGNPWEPGVKLTPLPEVEKPGYIKELIADALEKGATILNEKGGVLTDNFIFPAILYPVNTDMKVYSEEQFGPVIPVIPFSDIEEPLHDMAESNYGQQVSLFGKNIETLSPLIDTLVNLVCRVNLNSSCQRGPDVYPFTGRKDSAFGTLSVHDALRSFSIRTFVASKDNSYNNTILKELLDKKTSNFISTDYIL
>CP022985.1|AXP81183.1|2443421_2444039_+|hypothetical-protein
MEIVIADISHSKYAEIICETIAESAAVRGTGIARRTPEYITKKMVNGNAVIALDGDTFAGFCYIELWGHGKFVANSGLIVHPDYRGAGLAKKIKHKVFKHSRTKFPDAKVFSITTGLAVMKMNTDLGYKPVPFSELTDDPTFWDGCQTCKNYDVLTRTNRKMCLCTGMLYDPKDKDKSEPKKIKEKVFNRLKHIKETMFLKKDKK
>CP022985.1|AXP81184.1|2444081_2445257_+|Argininosuccinate-synthase
MKKLVIAYSGGLDTSYCAVSLSKKFDVHAVSVNTGGFTKAEIEHIESNAYKMGVSTYKNIDAVATFYQKVVKYLIFGNVLKNNTYPLSVSAERIIQAIEIVEYAKSIGAEYIAHGSTGAGNDQVRFDMIFQTLAPEIQIITPIRDEKLTRQEEIDYLKANGIDMSWEKAKYSVNKGLWGTSVGGSETLTSDKPLPDSAYPSQLKHAEDEKVKLTFERGELVAVNGIENDPEINIETLNNLAKAYAIGRDIHVGDTIVGIKGRVGFEAPAALITIKAHHLLEKHTLTKWQLQHKEYLASFYGMHLHEGQYLDPVMRNIEAFLQSSQDMVTGDVFVTLKPYHFNLDGISSEHDLMNAKFGSYGEENRGWTADEAKGFIKIFGNQNKIYHQVNS
>CP022985.1|AXP81185.1|2445260_2446238_+|N-acetyl-gamma-glutamyl-phosphate-reductase
MIQVGIIGGAGYTAGELIRLLINHPEVAIDFVYSTSNAGNNISSVHQDLFGDLDLKFTDTINPHVDVLFLCLGHGNSVKFLSANAFSQNTKIIDLGNDFRLEKDKVFHGKTFVYGLPELQRDAIKKANYIANPGCFATAIQLALLPLAEKGLLNSDVHINAVTGATGAGTSLSETSHFPWRDNNFSYYKPFTHQHLGEINQSVNQLQNGFDSEILFMPNRGNFSRGIFATVYTNFEGSLEEAKDVFKTFYKDAKFTFVSDEVLHLKQVVNTNKCLIHLHKHNNKLLVTSIIDNLLKGASGQAIQNMNLMFGLEEITGLQLKATYF
>CP022985.1|AXP81186.1|2446349_2447144_+|Pyrroline-5-carboxylate-reductase
MKIAIIGTGNLGSSIAKGLIKNKTFTSLYLSDKNTAAVNSFNVVDNVTVTSDNMLAVEQSDMVIFALQPKHINAVLESVASKITANHVVISVAAGVDIARIEGILGKDKNIIRVMPNTAISIGKSMTCIAANDKAQDKVALAQNIFNQLGTTMVIPEDLVQAATVICASGIAFWMRLVRATTQGAIQLGFEAEQAHELATQTCFGAASLLLESGRHPEQEIDRVTTPSGCTIEGLNAMEHQGLSSALIQGIVASFEKINQIKKN
>CP022985.1|AXP81187.1|2447145_2448291_+|Acetylornithine-aminotransferase
MPLFDVYPLYNVTPVSGKDMHVYDDAGVEYLDLYGGHAVISIGHSHPNYVEAVTNQVSKLGFYSNAIQNPLQVELADKIEKLSGCKGYELFLCNSGAEANENALKLASFKTGKARVIAFNNGFHGRTSAAVAATDNKNIVAPINAQQQVTFLALNDIDGVKRELEKGDVCAVIVEFIQGVGGLDQGTATFFEEVDALCKANNTYFIADEVQSGYGRSGKFFAFQYYNVTPEIISIAKGMGNGFPIGGILIHPSIEAKHGMLGTTFGGNHLACAAGLAVLNTIEDEKLIDNVNDISAYFISIAKTIPQIKNIKGKGLMIGLEFDFEVGELRKKLIYEHHIFTGGASNKKLIRILPPLTIKKAHVNQFFEALKKTLEPIEVEK
>CP022985.1|AXP81188.1|2448397_2449594_+|Gamma-glutamyl-phosphate-reductase
MNTLLNIETRNDVLLKMAALLDSERAAIIKINKADLDAYDGADISMYDRLKVDDSKVDEMIASVTHLAAQRDPVGIERFSFKHDNGMQVYNKTASFGTVLIIYESRPDVTVEAAGIAFKSGNKILLKGGKESLKSNLKIVELWHQALKEHGASTDWVEYLQFNRTETQAFLENPTQKVDLIVPRGGERLIAFVKQHATCPVIISGRGNNFVYVHKEADQQIALDVIINAKTAKISACNALDKVLIDENLPNKEAFIKTLISKLKEFKVQILGDGAISKFEGVEAIGSDDIWYEEFLDYKIAMAEIDSNEATIAMINKYSGGHSSSIITTNNDVAETFMANVDTAAVYHNASTRFTDGSQLGLGGELAISTDKLHQRGPIGLEHLVTNKWYVHGNGQIR

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Crispr_ID: CP022985_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022985_5

3125032-3125115

Orphan

Consensus_repeat	Method
ACTGTGACTGAACACTGCAAACTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022985_5

>merge|CP022985|5|3125032-3125115|CRISPRCasFinder
ACTGTGACTGAACACTGCAAACTGAACACTGCAAACTGAAAACTGCGACTGCAACTGCAAACTGAGACTGAACACTGCAAACTG

>CP022985|5|5|3125032-3125115|CRISPRCasFinder
ACTGTGACTGAACACTGCAAACTG	AACACTGCAAACTGAAAACTGCGACTGCAACTGCAA
ACTGAGACTGAACACTGCAAACTG

Protein	Signature genes	Signature genes Name	Protein_function
CP022985.1\|AXP81730.1\|3122495_3123383_-\|Glycosyl-transferase-family-2	unknown	unknown	gnl\|CDD\|366154
CP022985.1\|AXP81736.1\|3130940_3131483_+\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP81728.1\|3120455_3121538_+\|PglA-protein	unknown	unknown	gnl\|CDD\|340839
CP022985.1\|AXP81741.1\|3135413_3136826_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377768
CP022985.1\|AXP81738.1\|3132435_3132930_+\|Flagellin-N-methylase	unknown	unknown	gnl\|CDD\|308985
CP022985.1\|AXP81725.1\|3116201_3117503_+\|Polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240530
CP022985.1\|AXP81737.1\|3131515_3132217_-\|Malonyl-acyl-carrier-protein-O-methyltransferase	unknown	unknown	gnl\|CDD\|225137
CP022985.1\|AXP81723.1\|3114008_3115808_+\|GTP-binding-protein-TypA/BipA	unknown	unknown	gnl\|CDD\|273597
CP022985.1\|AXP81727.1\|3118821_3120450_+\|Phosphoethanolamine-transferase-CptA	unknown	unknown	gnl\|CDD\|293741
CP022985.1\|AXP81734.1\|3128491_3130219_+\|Vitamin-B12-transporter-BtuB	unknown	unknown	gnl\|CDD\|238657
CP022985.1\|AXP81729.1\|3121551_3122499_-\|Putative-glycosyltransferase-EpsH	unknown	unknown	gnl\|CDD\|132997
CP022985.1\|AXP81724.1\|3115809_3116037_+\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP81735.1\|3130304_3130886_+\|Putative-amidase-domain-protein	unknown	unknown	gnl\|CDD\|377737
CP022985.1\|AXP81742.1\|3136834_3138070_+\|Lipoprotein-releasing-system-transmembrane-protein-LolC	unknown	unknown	gnl\|CDD\|226957
CP022985.1\|AXP81726.1\|3117539_3118835_+\|Polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240530
CP022985.1\|AXP81740.1\|3133996_3135154_-\|Penicillin-binding-protein-4*	unknown	unknown	gnl\|CDD\|365903
CP022985.1\|AXP81739.1\|3133173_3134007_+\|Fatty-acid-hydroxylase-superfamily-protein	unknown	unknown	gnl\|CDD\|377224
CP022985.1\|AXP81732.1\|3124122_3124806_-\|Cell-division-ATP-binding-protein-FtsE	unknown	unknown	gnl\|CDD\|225438
CP022985.1\|AXP81731.1\|3123382_3124120_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372616
CP022985.1\|AXP81733.1\|3125218_3128245_+\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|188247

Protein	Function_ID	Function_description	E-value
CP022985.1\|AXP81730.1\|3122495_3123383_-\|Glycosyl-transferase-family-2	gnl\|CDD\|366154	pfam00535, Glycos_transf_2, Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	3.36996e-10
CP022985.1\|AXP81739.1\|3133173_3134007_+\|Fatty-acid-hydroxylase-superfamily-protein	gnl\|CDD\|377224	pfam04116, FA_hydroxylase, Fatty acid hydroxylase superfamily. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.	2.37223e-24
CP022985.1\|AXP81728.1\|3120455_3121538_+\|PglA-protein	gnl\|CDD\|340839	cd03811, GT4_GT28_WabH-like, family 4 and family 28 glycosyltransferases similar to Klebsiella WabH. This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.	6.04397e-70
CP022985.1\|AXP81741.1\|3135413_3136826_-\|hypothetical-protein	gnl\|CDD\|377768	pfam07075, DUF1343, Protein of unknown function (DUF1343). This family consists of several hypothetical bacterial proteins of around 400 residues in length. The function of this family is unknown.	0
CP022985.1\|AXP81738.1\|3132435_3132930_+\|Flagellin-N-methylase	gnl\|CDD\|308985	pfam03692, CxxCxxCC, Putative zinc- or iron-chelating domain. This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex. However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.	7.66424e-14
CP022985.1\|AXP81725.1\|3116201_3117503_+\|Polysaccharide-biosynthesis-protein	gnl\|CDD\|240530	cd13125, MATE_like_10, Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins. This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	2.26648e-104
CP022985.1\|AXP81737.1\|3131515_3132217_-\|Malonyl-acyl-carrier-protein-O-methyltransferase	gnl\|CDD\|225137	COG2227, UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme metabolism].	2.00135e-13
CP022985.1\|AXP81723.1\|3114008_3115808_+\|GTP-binding-protein-TypA/BipA	gnl\|CDD\|273597	TIGR01394, GTP-binding_protein_TypA/BipA_homolog, GTP-binding protein TypA/BipA. This bacterial (and Arabidopsis) protein, termed TypA or BipA, a GTP-binding protein, is phosphorylated on a tyrosine residue under some cellular conditions. Mutants show altered regulation of some pathways, but the precise function is unknown. [Regulatory functions, Other, Cellular processes, Adaptations to atypical conditions, Protein synthesis, Translation factors].	0
CP022985.1\|AXP81727.1\|3118821_3120450_+\|Phosphoethanolamine-transferase-CptA	gnl\|CDD\|293741	cd16017, LptA, Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase. Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.	1.60181e-81
CP022985.1\|AXP81734.1\|3128491_3130219_+\|Vitamin-B12-transporter-BtuB	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	2.36188e-11
CP022985.1\|AXP81729.1\|3121551_3122499_-\|Putative-glycosyltransferase-EpsH	gnl\|CDD\|132997	cd00761, Glyco_tranf_GTA_type, Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold. Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.	5.71273e-33
CP022985.1\|AXP81735.1\|3130304_3130886_+\|Putative-amidase-domain-protein	gnl\|CDD\|377737	pfam06940, DUF1287, Domain of unknown function (DUF1287). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown. This family is related to pfam00877.	1.64246e-100
CP022985.1\|AXP81742.1\|3136834_3138070_+\|Lipoprotein-releasing-system-transmembrane-protein-LolC	gnl\|CDD\|226957	COG4591, LolE, ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane].	5.45761e-44
CP022985.1\|AXP81726.1\|3117539_3118835_+\|Polysaccharide-biosynthesis-protein	gnl\|CDD\|240530	cd13125, MATE_like_10, Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins. This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	3.69748e-100
CP022985.1\|AXP81740.1\|3133996_3135154_-\|Penicillin-binding-protein-4*	gnl\|CDD\|365903	pfam00144, Beta-lactamase, Beta-lactamase. This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	1.0756e-55
CP022985.1\|AXP81732.1\|3124122_3124806_-\|Cell-division-ATP-binding-protein-FtsE	gnl\|CDD\|225438	COG2884, FtsE, Predicted ATPase involved in cell division [Cell division and chromosome partitioning].	3.1314e-86
CP022985.1\|AXP81731.1\|3123382_3124120_-\|hypothetical-protein	gnl\|CDD\|372616	pfam13489, Methyltransf_23, Methyltransferase domain. This family appears to be a methyltransferase domain.	6.29728e-12
CP022985.1\|AXP81733.1\|3125218_3128245_+\|tetratricopeptide-repeat-protein	gnl\|CDD\|188247	TIGR02795, Uncharacterized_protein_in_oprL_3'region, tol-pal system protein YbgF. Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.	1.80112e-13

>CP022985.1|AXP81732.1|3124122_3124806_-|Cell-division-ATP-binding-protein-FtsE
MSNPILQLKNVSIYQGDSLVLSKVNVEINKGEFVYLIGKTGTGKSSFMKTLYGDLPLTEGEGHIVDFDLKTLKENDIPYLRRKLGVVFQDFKLLSDSTINENLLFVLRATGWKDKNEMNKRVEEVLSKVDMKTKGFKYPHELSGGEQQRVAIARALLNNPELILADEPTGNLDPQTSIEVMEVLQEINKNGNTILMATHDYALLLKYPSKTLKCEDSQVFEVEQRKG
>CP022985.1|AXP81731.1|3123382_3124120_-|hypothetical-protein
MYRFLKKNIKSLIPKKILFKNELLLRKFYGILYLGNKHECNVCNKKLKAFIPLGTNDLICPFCGSLARNRRLWDLLNKEGDIQGKLLHFSPSRSLYRNLKKIKSIDYYSSDFENEFLADYKFDITNINQESEKFDTIICYHILEHIIDDHKAMDELYRVLKPNGKIYIQTPFKEGAIYEDFSIVLPEDRLKHFGQDDHVRVYSVEGLTNRLENAGFNVSVKSFNNLDNNLYFGFKSPETVLIATK
>CP022985.1|AXP81730.1|3122495_3123383_-|Glycosyl-transferase-family-2
MLSILIPTFNYDIVPLVKEIHNQCVENSIEFEILAYDDASEFYTSENKIISHLSNTTYEISQTNLGRIAARQQLANTAKYDWLLFLDADVLPKSEQFIQNYLNTLKTNVDAIYGGFAYHEEPPKSNHTLRWKYGKTKEQVSSLIRNKTPYKIVISANFLIKKTVFLSINSQIESKDYGYDNYFGALLKARNTKVFHIDNEVFHLGIEDNSTYLKKIKQAVETLHHLYITSKITSCENDLLELFKTFKKNKLHIVFGLFFKWFQTSFEKQLTGKNPSITLLQLYKLSYICYIDHHI
>CP022985.1|AXP81729.1|3121551_3122499_-|Putative-glycosyltransferase-EpsH
MTPYFSVVISLYNKEKHIQSTIESVLAQSFVDFEIVVVNDGSTDNSEAIVRSINDKRIQIYSQENKGVSAARNLGIEKAKAELVAFLDADDYWYPNHLETLKTLYKILPNCGLYATAYVKQFNTVKINSIYKNIPTTPNWMGIVADYFESSQINSIAWTSAVMIPKKVFDTIGNFDTKITLGAGEDTDLWIRVGLKYDVGFCNTVTAIHNLHSDNRVSNTNTNMRQFINLDAYEATAHSKPSLKKYLDFNRYSIAKQYKLVNNNLKARELISKIDFNNLNWKQQLLLKMNNQLLRIFIKVKLLLRNLGCNLSSYK
>CP022985.1|AXP81728.1|3120455_3121538_+|PglA-protein
MKICIVTPSLGFGGAERSAAMQSIMLSEMGYEVHIVLISNLKSYDYKGTLCNLGILKDNSNTFYDKIKRINFLRKYLIKNKFDFIIDNRLRNNSIIHEFGICKYAYRKFKVIYVIHSSSYKKEILQNFYLKKWLLNSAHKIVAVNNRLLDLIRPFHNNKNMVCIENAIDLDYIRLQSNESLNIPFSYILFCGRLDEKSKNISLLINAYALSEIYIKGIKLIILGDGPDKSDYEQLVTRLKMNDYIIFKPFNSNPFVYMKHSLCTVLTSFYEGFGLVLIESLASGTPVISVDCETGPSEIVEHNVNGLLIDPDSVNLLSEAFKSVIGDKDMLNRFRKNALNSVQKFRKNVIAEKWRVVLEN
>CP022985.1|AXP81727.1|3118821_3120450_+|Phosphoethanolamine-transferase-CptA
MRLSKLNNIQFSIEIKFLVTVLFSFFVESIFVEFQYQRILNLIENLLFAFILIYTLYFLSHTKLRRFYFISAYFFFSVIVFIETSYYYIFNVNISPSSLYVLLETNNTEANEFLMFYLDKVLIVYGIFLFVFFIAGVVRCNIHCCLSKKIRFNFKSLLIIVVLILIVFRTPFKHQNLPYLILKSLYVVYFESKVFDNPTYQSDTGIFNDVNLVNNNNNKLYVVIIGESTTRKNMSLYGYGRKTNPLLSKQNGLRVFKNVISPHAGTTASLTKALSLDNYENSSKEKGSIIQLLNAANFETYWISNQQPVGFAETDITKLVYSCNNKFYLNTEDTEELNLYDNVIFDKIDYVINNNSDRNKVLFIHLKGTHFYYENKYPDSFNTFKDKPKTQIAINESEYKFINEYDNAVTYNDFIVNTVIDKIKRKRSESFVLYFSDHGEEVYHTIKFAGHNDDVGTLPMFEIPFILWESKDYKLKNNIKIELNRPYMTDDLFHSIADLCGIDNKYVDLERSIFSKSFKNRKRVILNNKDYDSLLKIENTKN
>CP022985.1|AXP81726.1|3117539_3118835_+|Polysaccharide-biosynthesis-protein
MIKKNIKNYNNNFLLKVASYNSLSVFFRLVSGFIVSKFMAIFIGPSGIAITGNLSNFMQSLESLSSLGMKNGVIKYVAENKDEPTKLKQVISSAFFVTLCIALFLSTLLFLFSKSISLFVFDKIEYSFLFEVSALMMPFYTLQVFFISILNGLKKVKELVQINIVGYILTTILIVFLLYREELKGALIAIVLTPFLLFASLFYKFSSFKFIFLNINLNFISKVYISRIGSFFSMTLFSGIMFPIIYLFIRNYLIDNVGVTEAGYWEASRKISNYYMLFIYTLFDLYLLPVLSEDANKVKFRATIFNFYKNVLPIALLGFVLIYFLRFFIIKLVFTDEFLKMNELFGWQLLGDFFRIVSLTMAYQFFAKKMSYHYVICEISLMIFICFSSIYLINHLSVLGAVKAHAFSYIFYTLLMFLVFRKQLFNTYEAK
>CP022985.1|AXP81725.1|3116201_3117503_+|Polysaccharide-biosynthesis-protein
MKKIIDYINKNVLIKVTSLQAASVLTRIIAGILTSKAIAIFIGPTGLALIGNLRNFVSSFQTIAILGFYNGAVKYISDFKDDVEALSKTISTIFYVGFISTILVSFFCYFNAQFINNVIFPDYNDYAFVIKVFAMVLPFYALNMFSFSIMNGFSKYKILIVINIIGQILSVSVALLLIYQNRINGALISVVIAESLIFLITLVGIINRRSLVPLIKVNSISFSFLKKMSTYSLMALFSAVIMPLVAIAIRSYIIENVGYKDAGFWEAMTRISKYYLMLVSSLMALYILPRFSEIDDIKEFRKEVFSFYKTVIPVLAIGLVVIYLLKPYIVVLIFSEDFKPVEDLFLWQLLGDFIKVLSMVIAYQFLAKKMFWHYILTEAFLVIILYTTSVYFIDLYDNGQGAVMAHFVSYVMYYGIILLIFGSSLFGVDAEKS
>CP022985.1|AXP81724.1|3115809_3116037_+|hypothetical-protein
MEFLGISDVEWIGYAAMATVLISFLMKSVNKLRIVNSFGCLLFVFYGVLLEPLSMPIIITNTAIFFINAYYLLKK
>CP022985.1|AXP81723.1|3114008_3115808_+|GTP-binding-protein-TypA/BipA
MANIKNIAIIAHVDHGKTTLVDKIMYHCQLFRENENTGDLILDNNDLERERGITITSKNVSVIYKDTKINIIDTPGHADFGGEVERVLNMADGVLLLVDAFEGPMPQTRFVLQKAIDLGLKPCVVINKVDKENCTPEEVHEKVFDLMFELGAEEWQLDFPTVYGSAKNNWMSNDWKDQTSNIEPLLDMVIEHIPAPKIVEGTTQMLITSLDFSSFTGRIAIGRLTRGGLKTGQNISLVKRNGSIVKTKIKEVHIFEGLGRKKVDEVQTGDICALVGLEGFEIGDTVADFENPQGLKTIAIDEPTMSMLFTINDSPFFGKDGKFVTSRHIKDRLTKELEKNLALRVNETDSADKFLVFGRGVLHLSVLIETMRREGYELQIGQPQVIIKEIDGVKCEPVEEMTIDLPESVSGKAIEMVTMRKGEMLSMEAKGDRMVCQFMIPSRGIIGLRNQLLTATAGEAIMAHRFKEYQPLKGGIPERQNGSLVSMEKGQAIPYSIDKLQDRGKFFVDPGEDIYEGQVIGENSRGDDMTVNVTKTKKLSNVRSSGADDKARIIPAIKFSLEEALEYIQKDEYVEVTPNHLRLRKIYLTEVDRKRNKSI
>CP022985.1|AXP81733.1|3125218_3128245_+|tetratricopeptide-repeat-protein
MTIKNSVSLLVAISFSFQIWAQQSATYTSNLVEYQKALSLYNNQQYLAAQSLFGSVKKDTKEAVLLSDCAYYIANCAVRLNQQNADQLVEDFVKDYPTSTKRNTAYVDVADYYFTNGKYAYARKWYDKVDENALGRNEKEKFYFNNGYSAFSSKQYKEAKQYLTRVENSKEYGSQAKYYIGFMAYEGDDYENANKYFEQVSDQEQYKEKLSYYQADLNFKLGNFEKAIQLAKDKLKSSDKNEVSELSKIIGESYFNLKQYAEAIPYLEAYKGKNGKWSNTDFYQLGYAHYKQGDYEKAISEFNKIIGGTNAIAQNAYYHLGESYIKLNKKQEALNAFKNASEMDFDLKIQEDAWLNYAKISYDIGNPYQSAPQVLAGYLDKYPKTTYKEEIETLLIDSYITSKNYKEALRLLEGKKSFENKVAYQKVAFYRGLELYNEGNYLEAKNLFEASLKEPRDASFTARATFWKAETDYNLTNYDAALISFKQFQQQSAATVTPEYKNIDYNLAYTYFKLKNYSQTAQYFNQFIASNKGTGNVRLNDAYLRLGDAYFVSSDYKNAINAYESAIKLGTSDADYAFFQKAISSGYVGQESKKIKELEQFITEYPKSKLRDDAMYELGNTYVKAGDTDKAMQVYNRLNSEYKMSSFVPKALLRQGLVYYNGSNNEQALSKFKQVASDYPETPEAVQAVATARLIYIDLGRVNEYASWVKTLKYVEVTDADLDNATYEAAEKQYLENNTDRAITQFNGYINQFPNGLHALQAHFYIAQMYYKKGLKDNAAPHYKYVVDTSRSEFSEEALSRLSQFYLETKSWNKAMPLLERLEDEANFPQNVVFAQSNLMKANYQLENYDTAVAYAEKVLANSTIDNKIKADANVIIARSAIKTGNETKAKEAYAKVETVATGETAAEALYYNAYFKNKEANYEASNTAVQKLAKDFSGYKYYSAKGLVLMAKNFYALKDAFQATYILESVIQNFTEFNDVVTEAKAELSKIKAQEAKTNSSIQTGGN
>CP022985.1|AXP81734.1|3128491_3130219_+|Vitamin-B12-transporter-BtuB
MRKHIKNIILVVFTLSVTLVFSQKKTTDTINTGVIDVVKPYTPTISDAFKVKEVPSLNDETTQTKKEIKYNIFSFPVASTFTPAKGKAATVDKAKPIKLYDNYATLGVGTYTTILGEVYLNHAISRTESVGGYVSHHSSGGGIEGLSYDDDFLNSKANVNYASRLRDLAWNVEGGVGYQRYNWYGVPESQLAVSQSNNIEVDHSFFNAHLGGDVSFEDTYINSASFLFRRFGDNQGSAENRFTFKTKVDVPINDFEIATDVVIDYLGGSFDRGYNTVDELNYGNIQVGVSSTYELKQDDLTLNLGASLFYMRDNEANDSKIYLYPNVTGTYRLVNDVLIAYGGIQGDLIQNSYYGFATENPFVSPTLFITPTDQLYNAYVGLKGKVTSNVSYNISGHYVADRSKALFRNNEITLTTQDYSYGNSFGIVYDNVKTLGVAGEINVDVNRNFKLALKAETFSYTTDDEAEAWNLPDFKGSLFLDYQISEKWFAGANLFYVGERKDQFFLNDGSTATTPFTVTLDSYFDANAHVGYHVNDQLSIFVKANNMANEGYHKWQNFPVQSAQFLAGATYKFDF
>CP022985.1|AXP81735.1|3130304_3130886_+|Putative-amidase-domain-protein
MRRLFLIIVFFCFNFCVSQKAIQKLNLSQAALELTKQKVTYDPSYFSIPYPNGDVPANKGVCTDVIIRAYRKMGVDLQKEVHEDMKAHFKWYPKTWGLKTPDKNIDHRRVPNLMTYFERQGADKPITNNAKDYIPGDVVCWNLSGAITHIGIVVNKKSNDGKRYLIVHNIGAGQVLEDCLFDFKIIGHYRFKN
>CP022985.1|AXP81736.1|3130940_3131483_+|hypothetical-protein
MKRLVLIISFFYLNFIGAQNDSIFIRKNIEPYADKPVYKTDTIIFKNPNFRNILIGNTILPQTSNQQGAKSYGLFFEEFNVKDCLDNESEPKPNKIIQITKKKNEWVIKALVYTNCCQDFLADVSVYNDNTINIMFTNYGMYCFCSCPFEITYKFRVEPFDGLSKIKFVSINGEATTKLE
>CP022985.1|AXP81737.1|3131515_3132217_-|Malonyl-acyl-carrier-protein-O-methyltransferase
MKDLFGKALLDYQNGHYTEDIITSTNISEEDDLPLPYLFREFKEMPKQEQKALKLAKGRVLDVGCGAGSHSLYLQEKGFQVKAIDISKGAIEVAKQRGVLHAEVKNILDESERFDTILLLMNGTGIFQELVNVSKYLTHLKSLLNPNGQILIDSSDIKYMYEDEDGGFWMDMNANYYGELDYYLSYKGKQEAPMKWLYLDFEKLQLACETVGLTCELVLEGDHFDYLARLIPA
>CP022985.1|AXP81738.1|3132435_3132930_+|Flagellin-N-methylase
MEQIISNLPKLAKDKHNENKKFFAKLKSKPPKNLDYVMQDLHEAEFKRTDCLDCANCCKTTGPLFTDKDIERIAKHFKMKTQQFINQYLRIDEDNDYVLQSVPCTFLGADNYCAIYEVRPKACREFPHTDRKKFQQISNLTLKNVAICPAAFNIVEEMKKRIRG
>CP022985.1|AXP81739.1|3133173_3134007_+|Fatty-acid-hydroxylase-superfamily-protein
METLLNYFETIPSSHRSLILVGGLTFFWLLEGAVPLFRFNYKKWQHAVPNIFFTLTTIIVNFSLAFLLLKSADWVMANNFGVLNWLPEMPLWLYIVLGVFLMDFFGAYLPHFVEHKVKPLWMVHLVHHSDHKVDATTANRHHPLESVIRFTFTLMGVVIIGAPMGIVLLYQSMSVVATQFTHANIKLPRKVDRILSYVLVSPDMHKVHHHYRLPYTDSNYGNIFSVWDRLLGTYMELDRDQLIYGVDVFPDEKENSTIKGLLKQPFQKYRKPTVTNQ
>CP022985.1|AXP81740.1|3133996_3135154_-|Penicillin-binding-protein-4*
MIYVSRFHDSRFHLSRFTISPFTIYKMKRIIASLMLLLSAIGFSQTIEKPSEVKTKTAKKLAKKFLRKNRIAGMSISVSQHGELIWSKGFGYSNKNPKTPVKPDTTIFRIASISKSITALALAKLVDNKLIDLDSSIYNYIPDYPKQPYDFTVRQLGGNLAGIRHYRDDTEYALNKKMSITEGLDLFKNDPLLFEPGTQFNYSSHGFVLLSEVIQKVSNKPFDVFVNDSIFKSLQMNHTMMDISDAMVPNKTQFYSATTFKKPVFAKAVANEYKVAGGGFLSTSEDVIKFGNEIISPQLVSKEALSEIITSQRLKTGKITGYGIGFSIGHSKNGTPKYYHTGGGVGASSILLVYPKEELVIAVLTNLTGVSMKDFGEELEAIFID
>CP022985.1|AXP81741.1|3135413_3136826_-|hypothetical-protein
MRFNVVKNTVLLFVLGMISCGNFSKEKIESLKTEESRDKRQETRDKRQDPTTNNQQPTTIVGANQTDAYLPLLKGKRVGIVANQTSVIFKERHETRDERQETRDKNQETRPKTQDLKPSTQYPVHSTQNPEPNTQHPTPSHTHLVDSLLSRNINIKTVFAPEHGFRGTADAGEHIKDGVDTKTGVPIVSLYGDNKKPKPEQLKHIDVMVFDIQDVGARFYTYISSLHYVMEACAEAHIPLLILDRPNPNGHYVDGPILEMEHKSFVGMHPIPVVHGMTIGEYATMINGEKWLKNGVSCELKVIPIKNYTHQTAYSLPIKPSPNLPNDTAINLYPSLCFFEGTNVSVGRGTDKQFQVFGSPFLDKTKYTYSFTPQPNEGAKQPPYQNKVCYGMNLSHTKKLNGLDLSYLINAYRATQNKSEFFNSFFTKLAGTKKLQQQIEDGLTETDIKASWQQGLDGFRKVRDKYLIYE
>CP022985.1|AXP81742.1|3136834_3138070_+|Lipoprotein-releasing-system-transmembrane-protein-LolC
MNYEFFLAKRIIGSKAYKSSVSAPIIKIGIAAITIGMVVMMVAIATGIGLQQKIRDKVVAFNGHVTISNYDSNNSQESLFPISKKQDFYPEFKSVEGVKHIQAVASRFGVIRTETDFEAAYLKGVGADYDWAYFKDFLVEGKLPDYTKDRNEDVLISQYLANRLGFKVNDTFQMVFPKEDAEKLPNIITYKITGIYNSGFQELDAQYLLGDIRHIQRINQWNDDQIGNFEVFIDDYDQLPTKGIEIYRSTPSTLNTQTITEKYASVFEWINIFDKNIYGIIGIMILVAGINMITALLVLILERTQMIGILKALGSNNWSIRKLFLYNASYLIILGLFWGNLIGLSLLFAQKYFKLFPLDPSVYYVTEAPVYIGVGYIVALNIGTMLLCLLMLLVPSYIITKISPVKAIRFE

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Crispr_ID: CP022985_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022985_6

4629652-4629772

Orphan

Consensus_repeat	Method
TTTCATCTGTTAATATTTATTGTTTTTCAATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022985_6

>merge|CP022985|6|4629652-4629772|CRISPRCasFinder
TTTCATCTGTTAATATTTATTGTTTTTCAATTGTCAGATGGAACACCTTTAACAATCATCCCCATGTATGAACAACTGTTCTCATGGTGTTTCATCTGTTAATATTTATTGTTTTTAATTT

>CP022985|6|6|4629652-4629772|CRISPRCasFinder
TTTCATCTGTTAATATTTATTGTTTTTCAATT	GTCAGATGGAACACCTTTAACAATCATCCCCATGTATGAACAACTGTTCTCATGGTG
TTTCATCTGTTAATATTTATTGTTTTTAATTT

Protein	Signature genes	Signature genes Name	Protein_function
CP022985.1\|AXP82908.1\|4630902_4631283_+\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP82914.1\|4638389_4640021_+\|Phosphoenolpyruvate-carboxykinase	unknown	unknown	gnl\|CDD\|236471
CP022985.1\|AXP82904.1\|4627831_4628170_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378240
CP022985.1\|AXP82910.1\|4632526_4633537_+\|Aminopeptidase-S	unknown	unknown	gnl\|CDD\|349910
CP022985.1\|AXP82897.1\|4619481_4620435_-\|PhoH-like-protein	unknown	unknown	gnl\|CDD\|376820
CP022985.1\|AXP82912.1\|4635452_4636172_-\|1D-myo-inositol-2-acetamido-2-deoxy-alpha-D-glucopyranoside-deacetylase	unknown	unknown	gnl\|CDD\|274915
CP022985.1\|AXP82913.1\|4636512_4638354_+\|Sodium-dependent-dicarboxylate-transporter-SdcS	unknown	unknown	gnl\|CDD\|238535
CP022985.1\|AXP82911.1\|4633669_4635034_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|290319
CP022985.1\|AXP82916.1\|4640763_4641363_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226078
CP022985.1\|AXP82900.1\|4622478_4622973_+\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP82909.1\|4631411_4632464_+\|Bacterial-leucyl-aminopeptidase-precursor	unknown	unknown	gnl\|CDD\|349910
CP022985.1\|AXP82896.1\|4618581_4619100_-\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP82899.1\|4621762_4622476_+\|ABC-2-family-transporter-protein	unknown	unknown	gnl\|CDD\|132557
CP022985.1\|AXP82901.1\|4622956_4624624_+\|ABC-type-uncharacterized-transport-system	unknown	unknown	gnl\|CDD\|274627
CP022985.1\|AXP82907.1\|4630117_4630891_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378635
CP022985.1\|AXP82903.1\|4626231_4627596_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|290319
CP022985.1\|AXP82905.1\|4628241_4628709_-\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP82915.1\|4640094_4640769_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378471
CP022985.1\|AXP82898.1\|4620679_4621534_+\|Adenosyl-chloride-synthase	unknown	unknown	gnl\|CDD\|376645
CP022985.1\|AXP82902.1\|4624930_4626049_+\|DNA-polymerase-III-subunit-beta	unknown	unknown	gnl\|CDD\|238082

Protein	Function_ID	Function_description	E-value
CP022985.1\|AXP82914.1\|4638389_4640021_+\|Phosphoenolpyruvate-carboxykinase	gnl\|CDD\|236471	PRK09344, PRK09344, phosphoenolpyruvate carboxykinase.	0
CP022985.1\|AXP82904.1\|4627831_4628170_-\|hypothetical-protein	gnl\|CDD\|378240	pfam09685, DUF4870, Domain of unknown function (DUF4870).	4.60211e-32
CP022985.1\|AXP82910.1\|4632526_4633537_+\|Aminopeptidase-S	gnl\|CDD\|349910	cd05660, M28_like_PA, M28 Zn-peptidase containing a protease-associated (PA) domain insert. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins containing a protease-associated (PA) domain insert which may participate in substrate binding and/or promote conformational changes, influencing the stability and accessibility of the site to substrate.	9.49036e-111
CP022985.1\|AXP82897.1\|4619481_4620435_-\|PhoH-like-protein	gnl\|CDD\|376820	pfam02562, PhoH, PhoH-like protein. PhoH is a cytoplasmic protein and predicted ATPase that is induced by phosphate starvation.	1.15604e-126
CP022985.1\|AXP82912.1\|4635452_4636172_-\|1D-myo-inositol-2-acetamido-2-deoxy-alpha-D-glucopyranoside-deacetylase	gnl\|CDD\|274915	TIGR04001, thiol_BshB1, bacillithiol biosynthesis deacetylase BshB1. Members of this protein family are BshB1 (YpjG), an enzyme of bacillithiol biosynthesis; either BshB1 or BshB2 (YojG) must be present, and often both are present. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs].	2.26622e-115
CP022985.1\|AXP82913.1\|4636512_4638354_+\|Sodium-dependent-dicarboxylate-transporter-SdcS	gnl\|CDD\|238535	cd01115, SLC13_permease, Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.	1.48498e-49
CP022985.1\|AXP82911.1\|4633669_4635034_+\|hypothetical-protein	gnl\|CDD\|290319	pfam13586, DDE_Tnp_1_2, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	0.000299739
CP022985.1\|AXP82916.1\|4640763_4641363_-\|hypothetical-protein	gnl\|CDD\|226078	COG3548, COG3548, Predicted integral membrane protein [Function unknown].	6.03449e-50
CP022985.1\|AXP82909.1\|4631411_4632464_+\|Bacterial-leucyl-aminopeptidase-precursor	gnl\|CDD\|349910	cd05660, M28_like_PA, M28 Zn-peptidase containing a protease-associated (PA) domain insert. Peptidase family M28 (also called aminopeptidase Y family), uncharacterized subfamily. The M28 family contains aminopeptidases as well as carboxypeptidases. They have co-catalytic zinc ions; each zinc ion is tetrahedrally co-ordinated, with three amino acid ligands plus activated water; one aspartate residue binds both metal ions. This subfamily is composed of uncharacterized proteins containing a protease-associated (PA) domain insert which may participate in substrate binding and/or promote conformational changes, influencing the stability and accessibility of the site to substrate.	2.70749e-90
CP022985.1\|AXP82899.1\|4621762_4622476_+\|ABC-2-family-transporter-protein	gnl\|CDD\|132557	TIGR03518, ABC_transporter_permease_protein, gliding motility-associated ABC transporter permease protein GldF. Members of this protein family are exclusive to the Bacteroidetes phylum (previously Cytophaga-Flavobacteria-Bacteroides). GldF is believed to be a ABC transporter permease protein (along with ATP-binding subunit, GldA and a sunstrate-binding subunit, GldG) and is linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae and Cytophaga hutchinsonii. Knockouts of GldF abolish the gliding phenotype. Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Bacteroidetes with members of this protein family appear to have all of the genes associated with gliding motility.	6.88834e-112
CP022985.1\|AXP82901.1\|4622956_4624624_+\|ABC-type-uncharacterized-transport-system	gnl\|CDD\|274627	TIGR03521, gliding_motility_protein_GldG, gliding-associated putative ABC transporter substrate-binding component GldG. Members of this protein family are exclusive to the Bacteroidetes phylum (previously Cytophaga-Flavobacteria-Bacteroides). GldG is a protein linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae and Cytophaga hutchinsonii. Knockouts of GldG abolish the gliding phenotype. GldG, along with GldA and GldF are believed to compose an ABC transporter and are observed as an operon. Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Bacteroidetes with members of this protein family appear to have all of the genes associated with gliding motility.	0
CP022985.1\|AXP82907.1\|4630117_4630891_+\|hypothetical-protein	gnl\|CDD\|378635	pfam11306, DUF3108, Protein of unknown function (DUF3108). This is a bacterial family of putative lipoproteins. Structure 3fzx, the first structural template for this large family including several homologs in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Bacteroides fragilis glyA is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA\|QNQDC, and a Phobius server prediction of non-cytoplasmic localization for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit Structure 2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.	3.26811e-40
CP022985.1\|AXP82903.1\|4626231_4627596_+\|hypothetical-protein	gnl\|CDD\|290319	pfam13586, DDE_Tnp_1_2, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	0.000299739
CP022985.1\|AXP82915.1\|4640094_4640769_+\|hypothetical-protein	gnl\|CDD\|378471	pfam10677, DUF2490, Protein of unknown function (DUF2490). This is a bacterial family of uncharacterized proteins. They appear to belong to the outer membrane beta barrel superfamily.	3.81842e-34
CP022985.1\|AXP82898.1\|4620679_4621534_+\|Adenosyl-chloride-synthase	gnl\|CDD\|376645	pfam01887, SAM_adeno_trans, S-adenosyl-l-methionine hydroxide adenosyltransferase. This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme. S-adenosyl-l-methionine hydroxide adenosyltransferases utilizes a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion. This family used to be known as DUF62.	1.09955e-90
CP022985.1\|AXP82902.1\|4624930_4626049_+\|DNA-polymerase-III-subunit-beta	gnl\|CDD\|238082	cd00140, beta_clamp, Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric ring formed by PCNA (found in eukaryotes and archaea) and the processivity factor (found in bacteriophages T4 and RB69). This structural correspondence further substantiates the mechanistic connection between eukaryotic and prokaryotic DNA replication that has been suggested on biochemical grounds. .	4.88367e-119

>CP022985.1|AXP82905.1|4628241_4628709_-|hypothetical-protein
MKYLIIGLLVFSMIGCKDNRYTINMNTADFYGKKADPHPGKKLMEMYCYACHDAKTPEENRLGPPMIAIKMRYIFKDTSKDEFINDIQNWIKNPSEKDAKMFGAVKRFGVMQKLPYPENDVEQIADYIFDNDIEEPEWFQEHMNQNMGKGMKGMR
>CP022985.1|AXP82904.1|4627831_4628170_-|hypothetical-protein
MREDNQLLVITHLSQLVTLVTGFGSLLIPLIIWLTQKDKVYQMDAHGKNIVNFQLSLIVYFIICIPLILLLGLGILGFIVLGIISIIFPIINAIKTSNGEIPKYPLSFTFIN
>CP022985.1|AXP82903.1|4626231_4627596_+|hypothetical-protein
MPKIIRLSEFQYEIPIFAINKDFDGFYAQFLKTDLGKIYLSTPFSELGQSFKLKDSKKGTHCYFSPKGKIALMMLKNYYGCSDKKLIELLNGNIFMQFFCDILIPIDKPLTNFKIVSQIRMELSKGLNIRRSQEVLAKNWIPYMKDLDKMFTDATCYESEVRFPTNQKLLWECVQWNYRQMESLCRTLKIKLPRTKYLDWCRRYNEYSKKRKKQSKYRTKVTRGLLKLLYKLNGALGQIENQYPFESTAKYKRQRSIIAKVYRQQAQIFKTGKSVPDRIVSISKSYIRPIVRGKETKQVEFGAKVNKVQIDGINFIEHIQYRAFNEGTRLQSSVSCAQNLTKTKIKILGADAIYATNKNRTFTSSRKIQTDFIRKGKAGKNEEQRKILAREIKKERSTRLEGSFGKEKEHYNLKKIKAKTQKSEILWIFFGIHTANALEIGRRIYSSRFKNLAA
>CP022985.1|AXP82902.1|4624930_4626049_+|DNA-polymerase-III-subunit-beta
MKFIVSSTYLLKQLQVLGGVINSSNTLPILDNFLFELDGSMLTVSASDLETTMASSLEVESDSKGSVAIPARLLLDTLKTFPEQPLTFVIEDNNTVEISSNHGKYALAYADGKEFPKAVSLEDPSKTVVIGDVLATAISKTIFAAGNDDLRPVMSGVFFQFSTQGLTFVATDAHKLVKYTREDVKANQVAEFIMPKKPLNLLKGILAGSENEVTIEYNDSNAKFTFENSELICRLIDGKYPNYEAVIPKENPNKLVIDRTQFLNSVRRVSIFSNKTTHQIRLKIAGAELNISAEDIDYSNKAEERLTCDYQGDDMQIGFNSRFLTEMLNNLNSDEVQLEMSMPNRAGILTPIDGLDDGEQVTMLVMPVMLNS
>CP022985.1|AXP82901.1|4622956_4624624_+|ABC-type-uncharacterized-transport-system
MKKHLKHITILLIALIAINYISSLAFKRFDLTDDKRYTLSEATINIIKNVDSPIEIDVFLSGEDFPSEFRRLQNETKQLLEEFSSENSNIIFNFINPLEDDATRERHIQQLTDRGLTPMQLSVQENGKTSQAIIFPWALASYNGKTVIISLVKNKIGASQQDLVTNSVQHLEYAFADGFSKLTNPKHKSIAILKGNKQLADKYIASFIRKLGEYYFIAPFTLDSVANNPQKTLDGLNHFDLIISAKPTEAFTEEEKLVLDQYTMNGGKSLWLIDAVAMEKDSLYNDRGKNFATSRDLNVTDFFFKYGVRINPVMVSTLYSAPITLAMGEGSESQFQHLRWPYAPLASTNDNHPIVNNLNLVKFDFANQIDTLKNDIKKTILLESAPLTKLEGTPREISLEIVTQDPDPATFNKGNQTLAVLLEGEFTSVYANRIKPFELQKEINKSVPTKMIVIADGDVIKNDVFKNVPQELGFDRWTGQTYGNKEFLLNAVNYLLDDNGLINIRSKEITVEFLNQEKIADEKTKWQVINILLPLLLLGAFGVLFNYFRRKKYAN
>CP022985.1|AXP82900.1|4622478_4622973_+|hypothetical-protein
MILTPLFVIFLIVVFLLVWAFTNTIDKRKWLSFLISIVLTPIVYFYVFYPLINIFSSYHHEKHFDAEAWTDKPALRYEMSNEMTKLQMFKGKTKSEVKAILGSSEWYGWDDSIKANSPNKWNYNLGYKPGAFNLTQECLELEFKNNKVESVKQYQLETKFEEAP
>CP022985.1|AXP82899.1|4621762_4622476_+|ABC-2-family-transporter-protein
MFAILKKEINTFFASPIGYLVIGFFLLLNGLFLWFFKGENNILDYGFADLSSFFLLAPWILIFLIPAVTMRSFSDEKKQGTLELLLTKPITHLNIVLGKYFGAFVLILIALLPTLLYVYTIYQLGNPVGNLDFGSTLGSYFGLLFLIAAYTAIGVFASTLSDNQIVAFITSVAICFMFYIGFESVADYTSSNFIEQLGMNAHYKSISRGVIDTRDIIYFLSITAFFIMLTKLNINKE
>CP022985.1|AXP82898.1|4620679_4621534_+|Adenosyl-chloride-synthase
MAIITLTTDFGEKDHFAGATKGAIYSELPNVKIVDISHSVSPFNILEAGYIIQNAYNSFPKGTIHIIGIDSEINEENKHIALKLDDHYFICANNGIMSMICSEIAPEKIVEINIHDKIQTSFPVLDVFVKVACHIARGGTLEVIGKTIPEIKPTKHITPFVNDDKTQIIGSVIYVDNYGNVVTNIKRPFFESIQKGRSFEVSARNNKFKKIHNRYSDIVNFEIPEEKRHDEGRGLVVFNSGGFLEIAVYKSNSATVGSASTLMGLGLMDAISVNFSTESMLPKS
>CP022985.1|AXP82897.1|4619481_4620435_-|PhoH-like-protein
MNEIIIELEEITPKEFFGAQNTNIELLKKYFPKLKIVARGNKIKAFGDDELLEEFDRRMKMLLNHFTKYNKLDENVIERVLTSQSSDDYSTSDSSGEVLVHGVGGKLIKAQTANQRKLVESMRANDMVFAIGPAGTGKTYTGVALAVQALKNKEVKRIILTRPAVEAGENLGFLPGDLKEKLDPYMQPLYDALRDMIPAEKLAMYIENGTIQIAPLAFMRGRTLDNAFVILDEGQNTTHNQMKMFLTRMGKNAKFLLTGDPGQIDLPRRTISGLKEALLILKNVEGVGMIFLDDKDVIRHRLVKKVIEAYKSIEHVD
>CP022985.1|AXP82896.1|4618581_4619100_-|hypothetical-protein
MKKLFLIIGIGLIGSTSIFAQETEIDITPNNSWFKAGVTASVPVGDTGDVSSFNLGLDLRGQYLFNPNFAIGAASGYSHYFGKDGFEDFGVIPVAGFVRYYFTPKGLFLGTDIGYGFLTNVDNNEGGLYVNPQIGYHNYDWNIYAFYQNTFAENDVDIQNVGVGVTYNIRFK
>CP022985.1|AXP82907.1|4630117_4630891_+|hypothetical-protein
MTRTLIHFVLFLSLTAPLFAQNKAIAAGEKLTYTASYNMSGVLTDIAQVIMETTQVKTSKATLLRLKCTAATYSKWDNFFKIRDLYESYVNPHSLTPYLYNRDVNEGNYFKNMKYTFNNSAHTVKSVMKRKNNSIKNSSIKINSGTKDIVSTLYYMRTFDYKSMPVGTKKSFTILFDNEEIKGIITYLGKETISTAIGKKACYKLAVGSSETHVLQGKNNNFLWLTADENKIIVYGKFKIPVGNGELKIKSVSGLKN
>CP022985.1|AXP82908.1|4630902_4631283_+|hypothetical-protein
MKKVFTILAIIASILAIIFSVLPISNLAVFPAASALVFGGIAFYLSKRAGEVKKIIQFTFLLTTCALAITTYKAFFIKTEVANTEILNEKEAQFEEEAIEELENLDIETSEFEDVENNTTDLDIEQ
>CP022985.1|AXP82909.1|4631411_4632464_+|Bacterial-leucyl-aminopeptidase-precursor
MKTFFILSAFTLVGTCATPKYTARIQSIKDSIKLEDSTLVINYANTITSKELSTHLYAFSSKDFEGRRVGEIGQKKAAEFIKTYYQKEGIKSPLGVNNYYQSIPEDFFSNGIKASENVLAYIKGSEKPDEVIIISAHLDHLGVTNDGQVNCGADDDGSGTVAIMEIAQAFNIAKEEGHGPKRSILFLHLTAEEIGKRGSEYYVLNPVFPLENTVTDLNIDMIGRVDDIHKNNENYIYLIGSDRLSKELHYLSEKVNNAFFNIDLDYRYNAERDKNQYYTRSDHYNFACKDIPVIFYFNGEHSDYHQPSDTPDKIAYDLLEKRTKLIFATAWQIANQSKRLQIDANNQFLN
>CP022985.1|AXP82910.1|4632526_4633537_+|Aminopeptidase-S
MKRTILLSCITLLIVSCSTCQNKNTANNADKATDYAKTITENNLKEALYIYASDEFEGRKTGEPGQKKAVEFIKNHYVDLGIPSPIADGDYFQEIPETFFSNNAKASENVLAYIKGSEKPDEVVIISAHLDHIGISRNGSINNGADDDGSGTVAILEIAKAFKEAADKGHGPKRSVLFLHVTGEEIGLYGSRYYTDVDPIFPLKNTVANLNIDMIGRVDPKHENQRNYLYLIGSDKLSQELHDVSEAVNKAYFNMEFDYTYNDDNDPNRFYYRSDHYNFAKNDIPVIFYFNGIHADYHKPTDTPDKIQYDLLETRARLIFHTAWELANRDKRIKAD
>CP022985.1|AXP82911.1|4633669_4635034_+|hypothetical-protein
MPKIIRLSEFQYEIPIFAINKDFDGFYAQFLKTDLGKIYLSTPFSELGQSFKLKDSKKGTHCYFSPKGKIALMMLKNYYGCSDKKLIELLNGNIFMQFFCDILIPIDKPLTNFKIVSQIRMELSKGLNIRRSQEVLAKNWIPYMKDLDKMFTDATCYESEVRFPTNQKLLWECVQWNYRQMESLCRTLKIKLPRTKYLDWCRRYNEYSKKRKKQSKYRTKVTRGLLKLLYKLNGALGQIENQYPFESTAKYKRQRSIIAKVYRQQAQIFKTGKSVPDRIVSISKSYIRPIVRGKETKQVEFGAKVNKVQIDGINFIEHIQYRAFNEGTRLQSSVSCAQNLTKTKIKILGADAIYATNKNRTFTSSRKIQTDFIRKGKAGKNEEQRKILAREIKKERSTRLEGSFGKEKEHYNLKKIKAKTQKSEILWIFFGIHTANALEIGRRIYSSRFKNLAA
>CP022985.1|AXP82912.1|4635452_4636172_-|1D-myo-inositol-2-acetamido-2-deoxy-alpha-D-glucopyranoside-deacetylase
MKLDILAIGAHPDDVELGCGATIAKEIANGKKVGIIDLTQGELGTRGTAETRFEEAENASKVLGVSMRLNLKFADGFFDNDKTHQLVLINKIREYQPEIVICNAIDDRHIDHSKGSKLVSDACFLSGLVKIETKTETGELQNAWRPKHVYHYIQWKNLEPDFVVDVSEFMETKMKAVLAYKTQFYDANSKEPETPISSKNFTDSILYRARDLGRLVGVEYAEGFNVERFVAVDSLFNLK
>CP022985.1|AXP82913.1|4636512_4638354_+|Sodium-dependent-dicarboxylate-transporter-SdcS
MVPLMLTILAITILLFIWGKFTPDVVALISMLSLFLTGILNITETLSGFSNPTVILIAALFIVGEGIAQTGWTAIAGKKFVEWAGKSIPKLLFMITLGAGLLSGLVSNTGTVATLTPLTISSAWSIGTLPSKMLMPLAFGSNTGGLLTLTGSPPNIIASNVLIDAGYKGFSFFEFALIGLPLLIATLLYFKYLGYKLLPKNKTNNRPVNIESTLHNWIEAYKVDNDYYRLRIRSLSPLINTKLEDWLFEKNYNVSIIRIKRRHPKVLKGIHTFEEFPSPQTELYYHDIITVKGETEAINKIMITFRLGLLPLEPIMDELKHNLINQEVGMTEVIVNPNSILVGRKYKLGDYFKRFGIQLLAASRNNKPLQDKEIVVKAGDAFLIRGTWEHIDELKKQHENLVIIGSPEGMAKNIENLNFKSYIALASLLIMIALMVFDIVPGSIAALISAGIVLLTGCVPISKAYKGISWTSVVLIAAMLPMGIALQKTGTAQLVATGLVDNLGAIHPIVLLAGVFLLTTLFSQVISNSATAVLMAPIAMLAASSLNLAPEPFMMVVAISASTAFLTPIGTPTNAMVMTAGGYKFLDYLKVGTPLLLLLFVITLILVPIIWPF
>CP022985.1|AXP82914.1|4638389_4640021_+|Phosphoenolpyruvate-carboxykinase
MNDATTLKPQKSLESYGLKNVTVHWNLQPEELQQITVEKNMGKETANGTLAINTGKFTGRSPQDRFIVKDDYTNEKVWWGKTNKPVSPENFKKLKNEVIKYLSGKELYARDGYVCAEPEFRTNIRTITELPWSNLFVYNMFLRPSKKELENFKEDWLVLCAPGYVCPDPAGFGIRQGNFSIINFTDKIALVGGSAYTGEMKKGIFSALNLILPVEKNVLPMHCSANVGKKGDTAIFFGLSGTGKTTLSADPERKLIGDDEHGWTADNTIFNFEGGCYAKVIDLTEEKEPDIFRAIRPGALLENVVLKDNGEVDYMNSSITQNTRVSYPIYHIDNIQETLYANNPKNIFFLTCDAFGVLPPVSKLTPGQAAYHFISGYTAKVAGTEAGITEPVPSFSACFGEPFMPLHPAVYGEMLSKKMQEAGVNVWLINTGWSAGPYGVGSRIKLKYTRTMITAILNGELDHVDYEQNPIFGLFMPKYCPGVPTEMLDPMNTWLQKGAYIGKAIQLAHSFHLNFEKFAHQASQQIIEGGPLIDEHHHLEEHI
>CP022985.1|AXP82915.1|4640094_4640769_+|hypothetical-protein
MKTITAFIALALAMPLCQAQKTPESSLGAWYMLDATHAVSNKIGIKTGVQLRSYEVFNNINLLFVYTGINYKISKNTTFTLTYGYLDIDRTFTDIGFPHLYENRIYEQLSYKHKLNKLPISHRLRIAHRFLNFAHKLDTKHRLRYCLGSKIALTEDYFLNVNNEFFANLKKDTARENRLYAAVGLNISKTNNIQLGYLNHKINGLNLHRLQVGIFIKTDLRKKL
>CP022985.1|AXP82916.1|4640763_4641363_-|hypothetical-protein
MMTKGRLEAFTDGVLAIIITIMVLELKVPHGGTFEDLKPLLPVFGSYILSFIYIAIYWNNHHHMMQTVKHVTGKILWANMHLLFWLSLIPFVSGWMGENHFTTAGVFLYGVVLLGAAIAYFVLQFLIIKSHGKDSILSKALGKDLKGKASPILYITGIISAFFNVWISGFMFVFVAIMWLIPDKRIENKLKEERFKNGL

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Crispr_ID: CP022985_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022985_7

4736351-4736473

Orphan

Consensus_repeat	Method
ACTAACTAATTCATATTAGCTTTAATTTTTGT	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of CP022985_7

>merge|CP022985|7|4736351-4736473|CRISPRCasFinder
ACTAACTAATTCATATTAGCTTTAATTTTTGTTAGCTTAATTTTTGCTTTTGAAAGTCATCAAATCCACAAACAACCATCAACTATCAACCACTACCTAATTCATATTAGCTTTAATTTTTGT

>CP022985|7|7|4736351-4736473|CRISPRCasFinder
ACTAACTAATTCATATTAGCTTTAATTTTTGT	TAGCTTAATTTTTGCTTTTGAAAGTCATCAAATCCACAAACAACCATCAACTATCAACC
ACTACCTAATTCATATTAGCTTTAATTTTTGT

Protein	Signature genes	Signature genes Name	Protein_function
CP022985.1\|AXP83023.1\|4743249_4745208_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379003
CP022985.1\|AXP83007.1\|4727098_4727662_+\|Isopentenyl-diphosphate-Delta-isomerase	unknown	unknown	gnl\|CDD\|240048
CP022985.1\|AXP83025.1\|4746077_4746980_+\|tRNA-dimethylallyltransferase	unknown	unknown	gnl\|CDD\|234626
CP022985.1\|AXP83012.1\|4730793_4731510_+\|Transcriptional-regulatory-protein-YehT	unknown	unknown	gnl\|CDD\|225818
CP022985.1\|AXP83026.1\|4746982_4747777_+\|Cadmium-2C-cobalt-and-zinc/H(+)-K(+)-antiporter	unknown	unknown	gnl\|CDD\|224151
CP022985.1\|AXP83019.1\|4738788_4739679_+\|putative-3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|180269
CP022985.1\|AXP83008.1\|4727775_4728543_+\|Inner-membrane-protein-YjjP	unknown	unknown	gnl\|CDD\|377697
CP022985.1\|AXP83011.1\|4729647_4730793_+\|Sensor-histidine-kinase-YehU	unknown	unknown	gnl\|CDD\|377675
CP022985.1\|AXP83021.1\|4741011_4741677_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|143483
CP022985.1\|AXP83017.1\|4736538_4737180_-\|Protein-L-isoaspartate-O-methyltransferase	unknown	unknown	gnl\|CDD\|178974
CP022985.1\|AXP83015.1\|4735240_4735699_+\|SsrA-binding-protein	unknown	unknown	gnl\|CDD\|376590
CP022985.1\|AXP83020.1\|4739740_4740979_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377633
CP022985.1\|AXP83009.1\|4728548_4729034_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378960
CP022985.1\|AXP83014.1\|4733293_4734895_-\|carboxy-terminal-protease	unknown	unknown	gnl\|CDD\|367567
CP022985.1\|AXP83010.1\|4729051_4729450_-\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP83018.1\|4737745_4738744_+\|4-carboxy-2-hydroxymuconate-6-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|223745
CP022985.1\|AXP83016.1\|4735721_4736261_+\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP83022.1\|4741958_4743146_+\|Excinuclease-cho	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|236123
CP022985.1\|AXP83024.1\|4745233_4746085_+\|Cyclic-nucleotide-gated-potassium-channel	unknown	unknown	gnl\|CDD\|366146
CP022985.1\|AXP83013.1\|4731584_4732985_-\|Dihydrolipoyl-dehydrogenase	unknown	unknown	gnl\|CDD\|235779

Protein	Function_ID	Function_description	E-value
CP022985.1\|AXP83023.1\|4743249_4745208_+\|hypothetical-protein	gnl\|CDD\|379003	pfam12969, DUF3857, Domain of Unknown Function with PDB structure (DUF3857). This family is based on the first domain of the PDB structure Structure 3KD4(residues 1-228). It is structurally similar to domains in other hydrolases, eg. M1 family aminopeptidase (3ebi, Z=10, rmsd 3.6A for 152 CA, seq id 12%), despite lack of any significant sequence similarity.	5.05124e-07
CP022985.1\|AXP83007.1\|4727098_4727662_+\|Isopentenyl-diphosphate-Delta-isomerase	gnl\|CDD\|240048	cd04692, Nudix_Hydrolase_33, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.32457e-47
CP022985.1\|AXP83025.1\|4746077_4746980_+\|tRNA-dimethylallyltransferase	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	3.48061e-140
CP022985.1\|AXP83012.1\|4730793_4731510_+\|Transcriptional-regulatory-protein-YehT	gnl\|CDD\|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	1.2086e-45
CP022985.1\|AXP83026.1\|4746982_4747777_+\|Cadmium-2C-cobalt-and-zinc/H(+)-K(+)-antiporter	gnl\|CDD\|224151	COG1230, CzcD, Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism].	4.29184e-36
CP022985.1\|AXP83020.1\|4739740_4740979_+\|hypothetical-protein	gnl\|CDD\|377633	pfam06245, DUF1015, Protein of unknown function (DUF1015). Family of proteins with unknown function found in archaea and bacteria.	5.00066e-156
CP022985.1\|AXP83008.1\|4727775_4728543_+\|Inner-membrane-protein-YjjP	gnl\|CDD\|377697	pfam06738, ThrE, Putative threonine/serine exporter. ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.	3.55312e-52
CP022985.1\|AXP83011.1\|4729647_4730793_+\|Sensor-histidine-kinase-YehU	gnl\|CDD\|377675	pfam06580, His_kinase, Histidine kinase. This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.	2.7749e-26
CP022985.1\|AXP83021.1\|4741011_4741677_+\|hypothetical-protein	gnl\|CDD\|143483	cd00635, PLPDE_III_YBL036c_like, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins. This family contains mostly uncharacterized proteins, widely distributed among eukaryotes, bacteria and archaea, that bear similarity to the yeast hypothetical protein YBL036c, which is homologous to a Pseudomonas aeruginosa gene that is co-transcribed with a known proline biosynthetic gene. YBL036c is a single domain monomeric protein with a typical TIM barrel fold. It binds the PLP cofactor and has been shown to exhibit amino acid racemase activity. The YBL036c structure is similar to the N-terminal domain of the fold type III PLP-dependent enzymes, bacterial alanine racemase and eukaryotic ornithine decarboxylase, which are two-domain dimeric proteins. The lack of a second domain in YBL036c may explain limited D- to L-alanine racemase or non-specific racemase activity.	2.60127e-93
CP022985.1\|AXP83017.1\|4736538_4737180_-\|Protein-L-isoaspartate-O-methyltransferase	gnl\|CDD\|178974	PRK00312, pcm, protein-L-isoaspartate(D-aspartate) O-methyltransferase.	5.66214e-81
CP022985.1\|AXP83019.1\|4738788_4739679_+\|putative-3-hydroxybutyryl-CoA-dehydrogenase	gnl\|CDD\|180269	PRK05808, PRK05808, 3-hydroxybutyryl-CoA dehydrogenase; Validated.	5.03824e-154
CP022985.1\|AXP83015.1\|4735240_4735699_+\|SsrA-binding-protein	gnl\|CDD\|376590	pfam01668, SmpB, SmpB protein.	4.61107e-73
CP022985.1\|AXP83009.1\|4728548_4729034_+\|hypothetical-protein	gnl\|CDD\|378960	pfam12821, ThrE_2, Threonine/Serine exporter, ThrE. ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N-terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.	3.6453e-17
CP022985.1\|AXP83014.1\|4733293_4734895_-\|carboxy-terminal-protease	gnl\|CDD\|367567	pfam03572, Peptidase_S41, Peptidase family S41.	1.68555e-19
CP022985.1\|AXP83024.1\|4745233_4746085_+\|Cyclic-nucleotide-gated-potassium-channel	gnl\|CDD\|366146	pfam00520, Ion_trans, Ion transport protein. This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.	1.26607e-31
CP022985.1\|AXP83018.1\|4737745_4738744_+\|4-carboxy-2-hydroxymuconate-6-semialdehyde-dehydrogenase	gnl\|CDD\|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	4.94612e-47
CP022985.1\|AXP83013.1\|4731584_4732985_-\|Dihydrolipoyl-dehydrogenase	gnl\|CDD\|235779	PRK06327, PRK06327, dihydrolipoamide dehydrogenase; Validated.	0
CP022985.1\|AXP83022.1\|4741958_4743146_+\|Excinuclease-cho	gnl\|CDD\|236123	PRK07883, PRK07883, DEDD exonuclease domain-containing protein.	6.41671e-44

>CP022985.1|AXP83016.1|4735721_4736261_+|hypothetical-protein
MIKKLLLLVLISFVSTTIQSQEKGKEAPKDYTENVLTIDSTVNSLYGVISGEKGKKRDWALFKFLFHPDGKLITSGRNNERKFQIRYMKPDDYIKSSGKWLVEKGFFEKEIHRTVDAFGNMAHVFSTFEAFYDEADDDPFMRGINSIQLLNDGDRWWIINVFWDNENRRNPIPKNYLPK
>CP022985.1|AXP83015.1|4735240_4735699_+|SsrA-binding-protein
MQKNINIQNKKARFLYEILDKYTAGIVLTGTEIKSIRSSKASIAESFCEFNEKGELFVINATIEEYAFGNYYNHRPKAERKLLLNKRELKKLQKEVQSSGLTIIPLRLFINEKGYAKMEIALAKGKKLYDKRETMKDRDNKRDLDRIKKNFK
>CP022985.1|AXP83014.1|4733293_4734895_-|carboxy-terminal-protease
MKKQFLFYVVLILLVSCGSIKKHNEQITMPHPVEDLRRDVDKVYNQLKKHHPKLYQYTSKEVLDFKFDSLKMSITTPITSREFYKKLAPVVAQIKQGHISVGSVSKRYTKKERKALKKRKFEFYDLEFEYLDNKLWVVGTRGNDSMFIGSEVLKIEDDIAADLVEQYKTRFTSDGYNQTLYNRAVSNHFSTFFYQDKGFLDSLKIEFRQKDSVFTKTFRRILKDEKTNKNDSLAKVIPEKLTKKEKQQNRMAAKRKRKENRKRGFIAATKEYTRNFNFIGKDSTVAYMKIRGFSNGNYRKFYKESFNKIDALKTEHLILDLRDNGGGRIAEIDYLYSFLTNKKYKLVEDSEVNSRLPYFKYLMSNTTPIVVKVSTVVLSPIIIAQNLIKTKKKDGRIYYNFRFSKEKEPHPLNYKGALYVIINGNSFSASSLLSTHLKANKRAVFIGEETGGAYNGCVAGIYKIHEMPNSKLKIRMGLMQIESSYKQTPDGYGIKPDVEIVPTIEDRNQHKDPELEWILNAIKTNETSILKRF
>CP022985.1|AXP83013.1|4731584_4732985_-|Dihydrolipoyl-dehydrogenase
MNSYDVAVIGSGPGGYVAAIRCAQLGMKTAIIEKYNTLGGTCLNVGCIPSKALLDSSHHYEDAIKHFEEHGIEIPGDIKVNLEKMIARKQAVVDQTTGGIDFLMKKNNIDVYQGLGSFKDATHITISGDETLVIEAKNTIIATGSKPSSLPFINIDKERIITSTEALKLKEIPKHLIIIGGGVIGLELGQVYKRLGAEISVIEFMDRIIPTMDSGLSKELNKVLKKQKFNINISHKVKSVERVGDEIIVKADNKKGEEIEFRGDYCLVSVGRRPYTDGLNAEAAGVKLTDRGQIEVNDHLQTSASNIYAIGDVVKGAMLAHKAEEEGVFVAETLAGQKPHIDYNLIPGVVYTWPEVAAVGKTEEQLKEAGVEYKTGSFPMRALGRSRASMDLDGFVKILADKKTDEILGVHMIGARAADMIAEAVVAMEFRASAEDVSRMSHAHPTFTEAIKEAALAATDDRALHI
>CP022985.1|AXP83012.1|4730793_4731510_+|Transcriptional-regulatory-protein-YehT
MQNQKNISCLIVDDEAIARDVIATHISKIENVTIVKSCSNAMEAFNIIRTHTIDLLFLDINMPDISGISLARSINKNIKIIFTTAYRDYAVEGFELQAVDYLLKPISFERLLQSINTYFEVYHQPKTTDEKPLESSSFMFVRSDRRMIKIDFEAIIYIESFSDYIKIHLKNEVIVTRETISAIEAKLPNNQFLRIHRSYIISIAHINSFTNEHVVINHKALTISRSYKKEVLERLERY
>CP022985.1|AXP83011.1|4729647_4730793_+|Sensor-histidine-kinase-YehU
MLKRQFIIKKIGQLLLHILFWCGVLLFYTYFFGFNSTNFNYILSFSLFLMPITITTTYVLIYKIIPEYLITKRYFRFGLYSIYTFIISAYLIVISVFYGLIYLSNFQYANMAPISRNLLFVGTAVYLVIIIVSAFKLLKLNLNHAEKTKKLETKILEAQLKLKEQELNYLKMQIHPHFLFNTLNTMYGFALRKADETPEMILKLSNLLDYLLYQIDKPFVLLTDEINHIKDYIELEKMRFNNTLFVSFNCHNSIESVNDLGASPRGIYRKNIENSKQTPEHSNLDYRVKIAPMLLLTFVENSFKHGRLKNSILTIKIDISCTKENIHFSIENTSSKSETPNKGIGLQNIQKRLDLLYKDHYILKVDNKEDLFKVTLTLKHS
>CP022985.1|AXP83010.1|4729051_4729450_-|hypothetical-protein
MLVISTQNSSIGDELAKRFNEGGPFFMALILISLLLSIFFLIRATLRLNKDEMTFKKMISLVSDMSLLGLVLGILASIMGMIEAFDTVDGTGDVSKMAGGLKVTFLTMLFGTVTFIISRIGIVILKGLQKSS
>CP022985.1|AXP83009.1|4728548_4729034_+|hypothetical-protein
MDIIIKLLEVAVWSGVAALGFGILFNIPKGTIVTVFVLGFFAGLIKFTLLKFDVHIVLATFIAVFFVAIVSIPTAHKIHHPPVVFCVPPVIPMIPGYFAYETVLSVMNFIFIEKDTVKRIALIDAIFSNGFTMFFILISITAGISLPLLLLRRSTVKKIEG
>CP022985.1|AXP83008.1|4727775_4728543_+|Inner-membrane-protein-YjjP
MDASKELIKTTNLLLEIASLLMVSGANTIRVNLSINRFAAGLNFKTSCFISHKSIIMTLYEEDSTQSCTRVKNIPPYAINFSVISAISKASWSAVNENWTLEQISNDIEKIKNQKRYSKLTVLIAVSLAGAGFCNIFKGDYLNMLVAFISTFIGLLVFQLTHKEKFNVYIRIFFGSFIASLCAGVGIVYNIGANPQTALATSILYLVPGVALINSFTDLLDNNIINGMVRFTTGLMTVLAIALGLFITMLIFQFN
>CP022985.1|AXP83007.1|4727098_4727662_+|Isopentenyl-diphosphate-Delta-isomerase
MDEYIDIVDEHGNPTGKSELKSVIHQKGYFHHTAHVWFYTKDGEVLLSQRSAKKSICPLMWDVSVAGHIDAGETPKQSAIREAEEEIGIAISESDLHPIGIFKCFQSYENGIVDNEFHNTFIAKITVPLSKLTIQEEEVEALKFVTLDAFKKLIENIGEDNHFVPSNKPYYQLVWRSIMEKLSKPST
>CP022985.1|AXP83017.1|4736538_4737180_-|Protein-L-isoaspartate-O-methyltransferase
MKDTFKHKGLRQQLVNVLKNKGIKNEAVLGAIGKVPRHLFMDSGFLDYAYKDMAFPIAADQTISQPYTVAFQTELLQVKKEDKILEIGTGSGYQTAVLCELGAKVYSIERQQELFKKTSNFLPKLGYRAKKLIFGDGYKGLKEEAPFDSIIVTAGAPFVPNPLLSQLKIGGRLVIPVGGDVQIMTLFIRKDTKEFEQHEFGEFRFVPLLEDKN
>CP022985.1|AXP83018.1|4737745_4738744_+|4-carboxy-2-hydroxymuconate-6-semialdehyde-dehydrogenase
MLNILFLLKTLNMMLKAGVLGAGHLGKIHLRLLKQSDKYELVGFYDADETNGKKVEAEFGYKFFNSIDALIDAVDMVDIVTPTLSHYDCAKKAISKGKHIFIEKPITNTVEEAEHIRELLAENNLRGQVGHVERFNPAYLAVKNDIKSPMFIETHRLAEFNPRGTDVPVVLDLMIHDIDIILSVVKSKIKNISASGVAVISSSPDIANARIEFENGCVANLTASRISLKKMRKARFFQKDAYISVDFLDKKCEVVKMKDAPENPGDFDMVLQNAEGEKKQIYFDNPHVANNNSILDELEAFADAINTNSSPVVTLHDGTEALRVATQIINCF
>CP022985.1|AXP83019.1|4738788_4739679_+|putative-3-hydroxybutyryl-CoA-dehydrogenase
MKNIAVIGAGTMGNGIAHTFAQSGFEVNLIDISETSLKNGMATITRNLDRMVAKETITEIQKEDTLKNISAFTSISEGVKNVSLVVEAATENVDLKLNIFKQLDETCAKDCILATNTSSISITHIAAVTSRPDKVIGMHFMNPVPIMQLVEIIRGYNTSDAVTNTIMDLSKTLGKTPVEVNDYPGFVANRILMPMINESIETLYNGVAGVHEIDTVMKLGMAHPMGPLQLADFIGLDVCLSILHVMYDGFKNPKYAPCPLLVNMVRAGKLGIKSGEGFYDYSESKKAEKISRQFLK
>CP022985.1|AXP83020.1|4739740_4740979_+|hypothetical-protein
MAKIIPFKAVRPVRDKVGLVASRSYQSYSKAELKARLEYNPFSFLHIVNPGYKYDKNIRGKERFNLVKNRYLEFKEDAIFIQDETPCYYIYKIVNRDGNSFSGIIAAASTEDYKNDVIKKHEDTIEYRENIFKDYLKTVGFNAEPVLLTYPDNTTIKTVISEVQKERAEYEFTTHFRDTHYLWLLKDAKLIDKIKHEFEKINTIYIADGHHRSASSCLLSEDLKSENNQHTGTEAYNYFMSYLIPESELKIYEFNRLVKDLNGLTKEAFLIQLDAIFRIEKRGKELYKPTQKHHFSMYLDGDFYSLFLRKTNHQFNTALDALDTQILHKTVLEPILGITNVRNNTRISYSHGQNDLVTIKSKVDSGEFAVGFGLVPITIGELKAIADNHLTMPPKSTFIEPKLRSGITIYEF
>CP022985.1|AXP83021.1|4741011_4741677_+|hypothetical-protein
MHIQDNLNHIKSILPKYVTLVAVSKTKPVSDLMEAYNAGQRIFGENKIQEMVEKHEVMPKDIDWHMIGHVQSNKVKYMASFVKLIHGVDNFKLLEEINKQAKKHNRIIDCLLQIKIASEDSKFGMTALEATDILKSDSFSKLKNIQVTGVMGMATFTDDENQIKKEFTLLKTTFDALKYHESFNFKPETISMGMSGDYALAIDCGSTMIRVGSSIFGERNY
>CP022985.1|AXP83022.1|4741958_4743146_+|Excinuclease-cho
MLRHAPKFYEVAKRIVEITEDCILVAHNAQFDYRILCTEFGRLGFEYVRPSLCTVELAKDLIPDQPSYSLGKLVRSLGIPVADRHRASGDALATVKLFQMLLDKDTAKSIIQQSIRLNPKLQLEPRHLDIINELPPITGVYYIHKSDGEIIYIGKSSNIKKRINQHFTNTNQKSKRIQAHVTAVTYEATGSELVALLKESEEIKRVKPIYNRALRRTVFTHALYSFVDDNNYINLKIDVVDGRKNPITTFSNRESGKSFITKAVEEYKLCQKLTGLYKTKTSCFNYDIKTCEGACIEKEPAESYNKRVEALINKNSYKNKNMVIIDKGRDIDEHSAILIENGVFKGLGFFNLNYQINNIEVLESIITPMKNNRDTQHIIQSYLRRNNRVKIILFD
>CP022985.1|AXP83023.1|4743249_4745208_+|hypothetical-protein
MKKNLTFLFVLFSLLSFSQEDYFPESYNVKFNDIKSSTFARDSTANALVIYDFGNSHVDPDDFELKTEIKRKVKILNREGFDKATISIHLYNSSKASQSVKNIMATTYNLVGNTIVSTKIDKKDIFEEKYDENHTLVKFTLPNIKEGSVIAYSYTLSSPFMFNYKGWSFQEDIPKLYSEYRASIPGNYEYNIKLVGGRKLKTNTTSVEKECLRAFNGGVAHCGKYVYAMEDIPAFIEEDYMTSKSNYLARIEYELKIFRGFNGVIDNYTKTWETVDSELRGDANIGKQLTKSVDTETLLSNDILNETDALKKAQSIYNYVQENYTWNDEYRIFHEVSVKDLIKNKSGNISSINILLHNLLESVGMEVKPILLSTRDNGFATKIFPVISEFNYLIVQATINDKTYLLDATDKYLNFGDIPFKCLNGYGRILDFKKGSDWINIEPEKPSTVQYKIELNLDANENMSGNVYGKKIGYHALDSRKAYYPNREVYINKIHDKYPYIEISNHKVLSEGKTSPDFIESYDIKYEDNVTGDHIYLNPFIMKFFNENPFKLQERTYPIDFGYKDTYYYAFKLNFDEAYTILEKPKDLALNLPDGKGQIILSSNLTDNSISLLLRIKFNETVFEPEYYPYLKEFFNKIVDVQTNSLILIKKK
>CP022985.1|AXP83024.1|4745233_4746085_+|Cyclic-nucleotide-gated-potassium-channel
MSIQQKKNWRTKLHEIIYEADTPAGKLFDVVLLITIIASILLVMLESVKSINAKYHDLLNISEWIITILFTIEYIVRIITVRKPFRYIFSFYGIVDLLSTIPKYISIIFGGVHALATLRALRLLRVFRILKLVRYLGASNNLARAIKASRAKISVFLFTVIIATIILGTIMYLVEGEENGFTNIPKSVYWCIVTLTTVGFGDIAPQTPLGQFIASLIMILGYGIIAVPTGIVSAEYTAQNKPKQEPEKDQWHLNTQSCPNCSAEKHKDNAKFCYKCGHNLHHA
>CP022985.1|AXP83025.1|4746077_4746980_+|tRNA-dimethylallyltransferase
MPKYLISIVGPTAIGKTALSIKLANYFNTEIVSADSRQFFKEMSIGTAAPSKEELAAAKHHFIHHKSIQDNYSVGTFEKEAINCLDKLFKTHDVVIMVGGSGLYVDAITKGLDDFPEVDSNIRQTLNTHLETKGLPYLQNQLKELDAVAYNTIAIDNPHRVIRALEICMGTGKPYSSFLKKKHVNRHFKTITIGLTAEREIIYNRINQRVDVMMEQGLLNEIKNLLPFKELNALNTVGYKELFNYLEGEWELDFAISEIKKNSRRFAKRQLTWFKRDKNTLWFDYLTNVSEIIKQINEAI
>CP022985.1|AXP83026.1|4746982_4747777_+|Cadmium-2C-cobalt-and-zinc/H(+)-K(+)-antiporter
MEKTIFEITKMDCPSEENLIRMKLDGISNIKHLEFDIPNRKLTVFHWGGIDDIEQSIRELNLGCKKLVSEQSNQTKFTDITNQKKLLYTVLLINFGFFLIEITTGIISKSMGLIADSLDMLADSFVYGLSLIAVGGTLIKKKNIAKLAGYFQITLAFIGFVEVLRRFFGNEKLPDFTTMIVVSVFALIANGICLYLLQKSKSKDEAHMKASMIFTSNDVIINLGVIVAGIMVNLLNSNKPDLIIGSVVFVLVIQGAFRILKLSK

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Crispr_ID: CP022985_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP022985_8

4813406-4813560

Orphan

Consensus_repeat	Method
CTGAGCTTGTCGTTTGTCAGACTGAGCTTGTCGAAGTCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP022985_8

>merge|CP022985|8|4813406-4813560|CRISPRCasFinder
AATAACGTTTGGTTTGTCAGACTGAGCTTGTCGTTTGTCAGACTGAGCTTGTCGAAGTCCATTACTACCACTGCTTTCGATAGCTTCGACAGGCTCATACTTCGACAAAACCTGTGCTGAACTTGTCGTTTGTCAGACTGAGCTTGTCGAAGTCC

>CP022985|8|8|4813406-4813560|CRISPRCasFinder
AATAACGTTTGGTTTGTCAGACTGAGCTTGTCGTTTGTC	AGACTGAGCTTGTCGAAGTCCATTACTACCACTGCTTTCGATAGCTTCGACAGGCTCATACTTCGACAAAACCTGTG
CTGAACTTGTCGTTTGTCAGACTGAGCTTGTCGAAGTCC

Protein	Signature genes	Signature genes Name	Protein_function
CP022985.1\|AXP83077.1\|4803648_4803870_-\|helix-turn-helix-protein	unknown	unknown	gnl\|CDD\|376540
CP022985.1\|AXP83095.1\|4822382_4823528_-\|PepSY-associated-TM-helix	unknown	unknown	gnl\|CDD\|377164
CP022985.1\|AXP83079.1\|4804454_4805081_-\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP83078.1\|4804037_4804241_+\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP83085.1\|4812266_4813217_+\|D-3-phosphoglycerate-dehydrogenase	unknown	unknown	gnl\|CDD\|240628
CP022985.1\|AXP83093.1\|4820726_4821392_+\|Lipoprotein-releasing-system-ATP-binding-protein-LolD	unknown	unknown	gnl\|CDD\|213222
CP022985.1\|AXP83076.1\|4803407_4803626_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379188
CP022985.1\|AXP83082.1\|4809461_4809869_-\|Ferredoxin	unknown	unknown	gnl\|CDD\|274171
CP022985.1\|AXP83080.1\|4805083_4806430_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379114
CP022985.1\|AXP83086.1\|4813760_4814198_+\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP83092.1\|4819895_4820483_-\|GTP-cyclohydrolase-1	unknown	unknown	gnl\|CDD\|236472
CP022985.1\|AXP83091.1\|4819554_4819839_-\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP83081.1\|4807252_4808845_-\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP83088.1\|4814537_4814870_+\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP83089.1\|4814953_4817182_+\|Heme/hemopexin-utilization-protein-C-precursor	unknown	unknown	gnl\|CDD\|238657
CP022985.1\|AXP83084.1\|4811017_4812082_+\|Phosphoserine-aminotransferase	unknown	unknown	gnl\|CDD\|235428
CP022985.1\|AXP83090.1\|4817206_4819558_+\|MG2-domain-protein	unknown	unknown	unknown
CP022985.1\|AXP83083.1\|4809882_4810944_+\|Acyl-CoA-reductase-(LuxC)	unknown	unknown	gnl\|CDD\|143399
CP022985.1\|AXP83087.1\|4814235_4814538_+\|hypothetical-protein	unknown	unknown	unknown
CP022985.1\|AXP83094.1\|4821469_4822279_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP022985.1\|AXP83077.1\|4803648_4803870_-\|helix-turn-helix-protein	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	1.66464e-08
CP022985.1\|AXP83095.1\|4822382_4823528_-\|PepSY-associated-TM-helix	gnl\|CDD\|377164	pfam03929, PepSY_TM, PepSY-associated TM region. The PepSY_TM family is so named because it is an alignment of up to five transmembranes helices found in bacterial species some of which carry a nested PepSY domain, pfam03413.	1.0463e-60
CP022985.1\|AXP83089.1\|4814953_4817182_+\|Heme/hemopexin-utilization-protein-C-precursor	gnl\|CDD\|238657	cd01347, ligand_gated_channel, TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.	6.37778e-39
CP022985.1\|AXP83085.1\|4812266_4813217_+\|D-3-phosphoglycerate-dehydrogenase	gnl\|CDD\|240628	cd05303, PGDH_2, Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains. Phosphoglycerate dehydrogenase (PGDH) catalyzes the initial step in the biosynthesis of L-serine from D-3-phosphoglycerate. PGDH comes in 3 distinct structural forms, with this first group being related to 2-hydroxy acid dehydrogenases, sharing structural similarity to formate and glycerate dehydrogenases. PGDH in E. coli and Mycobacterium tuberculosis form tetramers, with subunits containing a Rossmann-fold NAD binding domain. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	5.72588e-146
CP022985.1\|AXP83093.1\|4820726_4821392_+\|Lipoprotein-releasing-system-ATP-binding-protein-LolD	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	3.61076e-110
CP022985.1\|AXP83076.1\|4803407_4803626_-\|hypothetical-protein	gnl\|CDD\|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	0.000771331
CP022985.1\|AXP83083.1\|4809882_4810944_+\|Acyl-CoA-reductase-(LuxC)	gnl\|CDD\|143399	cd07080, ALDH_Acyl-CoA-Red_LuxC, Acyl-CoA reductase LuxC. Acyl-CoA reductase, LuxC, (EC=1.2.1.50) is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase. The fatty acid reductase, a luminescence-specific, multienzyme complex (LuxCDE), reduces myristic acid to generate the long chain fatty aldehyde required for the luciferase-catalyzed reaction resulting in the emission of blue-green light. Mutational studies of conserved cysteines of LuxC revealed that the cysteine which aligns with the catalytic cysteine conserved throughout the ALDH superfamily is the LuxC acylation site. This CD is composed of mainly bacterial sequences but also includes a few archaeal sequences similar to the Methanospirillum hungateiacyl acyl-CoA reductase RfbN.	1.24853e-05
CP022985.1\|AXP83082.1\|4809461_4809869_-\|Ferredoxin	gnl\|CDD\|274171	TIGR02512, Periplasmic_hydrogenase_large_subunit, [FeFe] hydrogenase, group A. This model describes iron-only hydrogenases of anaerobic and microaerophilic bacteria and protozoa. This model is narrower, and covers a longer stretch of sequence, than pfam02906. This family represents a division among families that belong to pfam02906, which also includes proteins such as nuclear prelamin A recognition factor in animals. Note that this family shows some heterogeneity in terms of periplasmic, cytosolic, or hydrogenosome location, NAD or NADP dependence, and overal protein protein length.	0.00161208
CP022985.1\|AXP83092.1\|4819895_4820483_-\|GTP-cyclohydrolase-1	gnl\|CDD\|236472	PRK09347, folE, GTP cyclohydrolase I; Provisional.	2.7644e-109
CP022985.1\|AXP83080.1\|4805083_4806430_-\|hypothetical-protein	gnl\|CDD\|379114	pfam13304, AAA_21, AAA domain, putative AbiEii toxin, Type IV TA system. Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.	2.31887e-13
CP022985.1\|AXP83084.1\|4811017_4812082_+\|Phosphoserine-aminotransferase	gnl\|CDD\|235428	PRK05355, PRK05355, 3-phosphoserine/phosphohydroxythreonine transaminase.	0

>CP022985.1|AXP83085.1|4812266_4813217_+|D-3-phosphoglycerate-dehydrogenase
MKVLANDGISKSGIEALEKGGFEVITTTVAQEQLANYINEKQISVLLVRSATTVRKDLIDACPSIKIIGRGGVGMDNIDVDYAISKGLHVINTPASSSHSVAELVFGHFYGLARFLHNSNRDMPLEGDVSFGKLKKAYAKGVELKGKTLGVLGFGRIGQATAKVALGAGMKVIAFDPFIEKANLELEFFDGQKVNFDIKTISKEDVLKQADFITLHVPAQKEYVIGAPEFEIMKKGVFIANAARGGVVDEAALVTAIESGKVAGAALDVFENEPKPEIQLLMNAGLSLTPHTGAATNEAQDRIGTELAEQIINLLK
>CP022985.1|AXP83084.1|4811017_4812082_+|Phosphoserine-aminotransferase
MKKHNFSAGPSILPQEVILKSSQAVLDFNNEGLSILEISHRSKAFIDVMEQARALVLELMGLEGKGYKALFLQGGASTQFLMVAMNLLEKRAGYLNTGAWSSKAIKEAKKLDDIYEVASSKDANFNYIPKGYDIPKDYDYFHCTSNNTIFGTQMKSFPNSPIPMVCDMSSDIFSRQLDFSQFGLIYAGAQKNMGPAGTTLVVVKEDILGKVSRNIPSIMDYKIHIDNGSMYNTPPVFSVYTSMLTLEWIKSLGGIKAVEELNEKKAQVMYSEIDLNPLFKGFAAKEDRSLMNATFTLENENLKETFETMLKEAGISGVNGHRSVGGYRASMYNALPIDSVKALVEVMSELESKA
>CP022985.1|AXP83083.1|4809882_4810944_+|Acyl-CoA-reductase-(LuxC)
MQLQQRISAFVKLGDFLSQFSNEVIQKKENVEHNALFFDGFKHQLKLAEEHNGWFTPENIRFAIKSWVDALTHDNLTKWLAPYTMNVTKPKQVAIIMAGNIPLVGFHDFLSVLITGHKVLVKQSSNDKHLLPYLAKYLEYVAPEFKGSIHFTEAKIENFDAVIATGSNNTARYFEYYFKGKPSIIRNNRNSVAVLTGQETEADLKNLAEDIFRYYGLGCRNVSKLFLPKGYNFDAFFNGMYHWHPIIDKAKYANNYDYNKAVYLMSEFDMLENGFLMIKEDPSYASPIATVFYEYYDDLSQLKDKLEADKSQIQCIVSNGFTENEIAFGATQKPQLWDYADSIDSVEFLLAIS
>CP022985.1|AXP83082.1|4809461_4809869_-|Ferredoxin
MNTFGVIFASTKLERKNTMAIIITDECINCGACEPECPNTAIYEGADDWRYKDGTSLTGKVVLTNGSEVDADEAQEPISDEIYYIVPDKCTECKGFHDEPQCAAVCPVDCCVPDDDHVETEEELLAKQRFMHPEE
>CP022985.1|AXP83081.1|4807252_4808845_-|hypothetical-protein
MEKDYFLLEDKKKEIESKFLIKNGWLKIYEDDSKDFDDSAGIYCCLISNDKVEKYSEDYNWPLSMGSEGKPSVYGDNTYRSNDEEGLEPFLLYKSFSLQETSIKYIDVAEEFVLYFRLYEKGNDKQNRTFYYVSDYGELDEVLTIEPKLIKVKIKYLREYITMRDMNFVVCYDFMRLLKKIPSDWNIKHKDELIKENDFIYSHLIRNVSEKTQSWVMGKSFIKPNDIKKSHFDFGESKNESFIIGIDDEGDLMYEDCGKTDGNHFKVTYFKKEVLNKYYNEPNKYQVDGFSVGSKFFRLKIDNNVDEYIPVFLTNLRMLPELEQLHWKQYNIPPKEGMNISRTYYRTMIEGQWAEQPETVDLFFKSKYKSFNKKWEEKFGWKLYKPLSKTDEYLFTALHKITSNNVKAFCEQTLTIVKLTIDRLNEKELAKGLSLDSKVRGIGKFEKFLESKGMNIPDMFEFLRNLQNLRSGLIAHTFSESNKDCKKALKYFGIESDNYTEVLEEIFVKSVFTFNTLEKYFELNEEKHSG
>CP022985.1|AXP83080.1|4805083_4806430_-|hypothetical-protein
MKISIKNLGPIKNAEFEISDFTAITGFNNTGKTYISYALYGFLKTWSTNTKNLELDEEINSFIENGSLTIKLSKFKKKVLGNFSQLTKNYSENIHNIFSANEEEYKQTEFNIRLNQNDILLKNTINSDISIKGKKILSVNKDQESEDLNFKINLESNTKLPPKYILSEIVSEYINEALLNEILPTPYIITSERTGINIFQNELDINKNVFFEKLAQSKTGKFDLNPFEYIDEVFNRYSIPIKDGIDRTRDIEKDFKQNSYISKEYPAIVKKLENSTGVGYKNNKGQYFITYKEGRKKIALPVYLGSSSSRALFDLYLFIKHTAKKGQLLIIDEPELNLHPKIQIQIARLLASLSNIGVKVMITSHSDYIVKEINNLIMLSSDFENKASFKKSHKYLEYEFLKNINFYITENSTLSHIETDKFGLLRTTFDDSIREMQNISDELYENLL
>CP022985.1|AXP83079.1|4804454_4805081_-|hypothetical-protein
MSINCIKNIFDGTSIIPSAQDEIIIRETDNNVKDNSLKKVKIKGINNPNLVCFKLDKYVPLTKYFNSINSDGINKGVDAVIFYIKDGKGYILFIELKSFTLNQKDVSNKFFASTAFIHQIGYLAKNIYGKNIHDFSSSAIVFSLNSKNDRVNKFGMRPDIPTVSNKSYSNSKSNIQVLEIQKNNGENFNISMDCILTKARHKELKNWP
>CP022985.1|AXP83078.1|4804037_4804241_+|hypothetical-protein
MSTRYTKADLEQIVFKQLENLNAMHDLIGIMKFQNNLLQNLNKTLKDEIGEFKEHQAMHPTRSKSEL
>CP022985.1|AXP83077.1|4803648_4803870_-|helix-turn-helix-protein
MTSKRNYNRIRVVLAEQDRTNKWLAEKVRKNRTTVSRWCTNDMQPSVETLAEIAEILNVDIRELLLPTKDVNN
>CP022985.1|AXP83076.1|4803407_4803626_-|hypothetical-protein
MTELGHYLSKKSASKAGISKKTGISKSRISELTLNPFTQLRAWELYLIALALGVDPGEMFKDIFTELKLPSK
>CP022985.1|AXP83086.1|4813760_4814198_+|hypothetical-protein
MKSIIYILLICGFAISCNTTKSTTANKNEKQENAKLSDTVTISNDELEYEIIIIEPGFNSWLVSMAKPEGFYSQQYLENRNLIYVNEWNNRVLQPQRYNPNLYEMQIDYQPDIDYGYEVNYKLYNYFIYFQLTYNQRLGPFVPRI
>CP022985.1|AXP83087.1|4814235_4814538_+|hypothetical-protein
MEKLKERWGIEQNWEIIVILIVFAITGSTASYIGKPILNYLNITTESFGSFGYWVTRIVLLFIMYQFMLVFFGWLFGQYKFFWNFEKKMLRRIGLKRLVG
>CP022985.1|AXP83088.1|4814537_4814870_+|hypothetical-protein
MQKAKEHIAFKTITLMLALALLVPTATKFAHIFAHHKHDICKGEKSTHLHEINTECDFYKFKISNAYTFTFFNIELISFEEDTLQIISQYQFLSDFQRLQTALRGPPALI
>CP022985.1|AXP83089.1|4814953_4817182_+|Heme/hemopexin-utilization-protein-C-precursor
MRILFNVLLFLAITNLYAQNSIKGTVTDATTNQGIPYANIYLSELEKGTYTNENGDFLLENLPSGNRKIVVSILGYETKSINILIPTTNSLTISLTPTAIEMQAVIVSTPFHKLQSENVMKVEHQTIANLKANGAVNLADGITNIAGVESVTTGLSIGKPVIRGLSSNRVLVYAQGVRLENQQFGDEHGLGLSDSGIESVEVIKGPASLLYGSDALGGVLYINPEKFAQSNTSNADFNGNYFSNTQGFSTNAGYKSSDDHFKFLFRGSLTEHADYKTNTYRVTNTRFKEQDFKAGIGYQKEDFKTEFRYNVNHSKLGIPEEIGEQSTSKTPLLPFQDITNHVFSSKSSVFFNDSRLDINLGYIYNDRKEFEEHHHEEEGEEEEHEEELEDENEILEAALHMKLKTANYDVKYNLPKLGKFETIVGIQGMNQVNTNYGEEQLIPNATTNDFGVLATSHIHFEKADVQLGARFDNRTIDVATGLQKNFNSFNGALGLKTDIAKKVTARINLATGFRAPNLSELTSDGSHEGTNRYEIGNENLESEQNFQTDIALEFKNEHVEFFVNGFYNTINNYIYLSPNGESIDGDPVFVYLQNDANLYGGEVGLHIHPHPLDWLHMESSFETVTGKQTDDSYLPLIPANSVTNILRVEFERPWLKKAYSFVKLTTTFNQNNASAFETNTAGYSLLSAGLGGSFNLFKNEATVTLSGTNLTNKTYVNHLSRLKPDGIFNMGRNINIGLTYNL
>CP022985.1|AXP83090.1|4817206_4819558_+|MG2-domain-protein
MILSFFLLKNKFHKNYGTIFLSILLLLASFSITYSQNKIVNQLASQITNLSEQHLSDVIYLQTSKGIYETEEDVWFKGYVLDAQLLLPSIKSKTLFVQLIEDKTNKAVWEEKYEIENGFVNGHLFLNDSLHTGSYTLAAYSSHSFYKGTKEFHALRKLQILRNIKNKPRQEFITKDSILNFATFPEGGDLVSGILNRIAFKAEDSKGLPIDVLGTLYENNIPITEFKSIHTGMGSFMFTPNSNNNYHIQLTEPKSDKIYNLPNIRSSGKTLQLLNINKDLALFKVSQSSDLTDKPIYLRVQSRGIVYNIAMGTLNKELLIKIPLKDIPHGIAEVTLFDENAVPVAERLIYVNPEQKLNIKTVLNKSEYLTREKAVLKIKVTDQNNEPVVAHLGLSVFDEIYNNKPDTKSILTHYYLSTQIKGNIYNPAYYFNEDNKDRHEALNLLLLTQGWRRYIWNEANLKGHDEHFQHLLSDSIVGHVRLENPNKKPDEQGQKIVMAYTPDALREKDMMMTDSKGFFSIEYKHFKMAEKGYLYIKPMTPEKPKYVIDIKDATFEDINTHRKATTTNYPLPKQEKEEQTENTNNDFIVPDEVNKLEEVLLSTKKKQVFRDKYIGVLDSLAKLDLNTDFVHHGWLNCPACTTGDKPIEGKIYTIFTGTDIPTSHPFTFGYPTREFKQIEYHYPKFTEDELLKKFNLKMLKGYYGYRKFYQPFYNEETANDPFPDYRNTLFWKPDIITNVQGEAVIEFYCSDINTNFSGAIEGINGTGLLGTEHFNFKVIKNNP
>CP022985.1|AXP83091.1|4819554_4819839_-|hypothetical-protein
MNDSMSKNKKLLLGLLFDGCGYISFVFPPFDFVWAPLSAYLMTKLYKGTSGKVAAAISFIEEALPFVDIIPSFTLMWIYTYVFSKEESVIDIKN
>CP022985.1|AXP83092.1|4819895_4820483_-|GTP-cyclohydrolase-1
MPYKNFEEFNMQVPDEVTDRYKNIIKDLGENTERDGLLKTPERAAKAMQFLTQGYHQDPVEILKSAMFKESYNEMVIVKDIELYSLCEHHMLPFFGKAHIAYIPNGHIVGLSKLPRVVDVFARRLQVQERLTEQILDCINDTLKPQGVAVVIEASHMCMMMRGVQKQNSVTTTSGFRGQFEKNETRNEFLKLIGK
>CP022985.1|AXP83093.1|4820726_4821392_+|Lipoprotein-releasing-system-ATP-binding-protein-LolD
MIQAKNIHKFYKDLEVLKGVDIHVQKGEVVSIVGASGAGKTTLLQILGTLDRASSKEPYELTINNVSINGLNDKALAKFRNEHIGFIFQFHQLLPEFTALENACLPAFIKGTKKADAEKRAKELLDFLGLSHRYNHKPNELSGGEQQRVAVARALINNPDLIFADEPSGNLDSESAENLHSLFFKLRDEFGQTFVIVTHNEELANLADRKLVMVDGKITNN
>CP022985.1|AXP83094.1|4821469_4822279_-|hypothetical-protein
MRKMIVPILALFFISCQEDDPKPHVDSASAMEALTEYAIVNKVFQDAGNNSGDAVLSSENSASVSKISKANAEGPIITVEPLDLTTFPKTITVDYQEGVLCKDGITRKGIATIVSTNWYGIEGSEHTTTFNNYYHNDYKVEGTHYVKNLGENTDGDLQYTVVIENGKITTKMGKTINYTENSTRTWVAGSDTPFNIWDDEYMLDGTQSGVSSKGVEYSLTIEESLHFVLLPRSIKSGILDIDVANIKDIKLNYTTSTITILGQTFPFGN
>CP022985.1|AXP83095.1|4822382_4823528_-|PepSY-associated-TM-helix
MAYKKNILWLHKILGLVTGVVVFIVAITGCCWAFKEEIESLYVDDYTVEIQNAPILTPTEVKTIGNSVFPNNTIHGSIFNNSNEAIEIIFYDAKPEFYQSVFLNPYTGDVMHIENHLSGFFSFILKGHMRLWFPKDIGEQIVGTSILIFILIIISGFILWVPKKRKNLKQRLKFMWKPTTRWKRKNFDLHAIVGFYICSLALILAFTGTIISYNWMKYVVYKAAGGEKVPQFIIPENESKTVNLDSETLAIDNLIVKLKNELPNAVSYELHYPQNDSSSVYVEVSNSKGVFYDTDFRFYDQNTLEELETPGVYGKYSDTKVAEKILRMNYDIHIGAIGGLPGKIIAFLVSLLTATLPVTGFLLWYGRKYKKEKPVKITDEK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

69489 : 85334

Flavobacterium_phage(100.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXP79164.1\|69489_69891_-	hypothetical protein	A0A1B0WM80	Flavobacterium_phage	5.5e-24	45.5
AXP79165.1\|69887_70055_-	hypothetical protein	NA	NA	NA	NA
AXP79166.1\|70091_70553_-	hypothetical protein	A0A1B0WMQ1	Flavobacterium_phage	1.2e-14	33.8
AXP79167.1\|70549_71482_-	hypothetical protein	A0A1B0WMB9	Flavobacterium_phage	1.6e-63	44.7
AXP79168.1\|71478_71778_-	hypothetical protein	NA	NA	NA	NA
AXP79169.1\|71793_72774_-	hypothetical protein	NA	NA	NA	NA
AXP79170.1\|72777_74139_-	hypothetical protein	A0A1B0WN37	Flavobacterium_phage	2.1e-115	43.5
AXP79171.1\|74128_74365_-	hypothetical protein	NA	NA	NA	NA
AXP79172.1\|74756_75131_+	hypothetical protein	NA	NA	NA	NA
AXP79173.1\|75193_75421_+	hypothetical protein	A0A1B0WM79	Flavobacterium_phage	2.7e-12	48.7
AXP79174.1\|75619_76030_-	hypothetical protein	NA	NA	NA	NA
AXP79175.1\|76007_76196_-	hypothetical protein	NA	NA	NA	NA
AXP79176.1\|76205_76424_-	hypothetical protein	NA	NA	NA	NA
AXP79177.1\|76479_76887_-	hypothetical protein	NA	NA	NA	NA
AXP79178.1\|76883_78587_-	hypothetical protein	A0A1B0WMQ6	Flavobacterium_phage	4.5e-160	48.1
AXP79179.1\|78558_79194_-	hypothetical protein	A0A1B0WMC9	Flavobacterium_phage	1.1e-34	37.0
AXP79180.1\|79177_79690_-	hypothetical protein	A0A1B0WML4	Flavobacterium_phage	5.5e-13	43.0
AXP79181.1\|79701_80028_-	hypothetical protein	NA	NA	NA	NA
AXP79182.1\|80020_80614_-	hypothetical protein	A0A1B0WN44	Flavobacterium_phage	6.8e-55	54.6
AXP79183.1\|80606_81011_-	hypothetical protein	A0A1B0WND1	Flavobacterium_phage	1.5e-16	44.0
AXP79184.1\|81121_82135_-	hypothetical protein	NA	NA	NA	NA
AXP79185.1\|82293_83121_-	hypothetical protein	NA	NA	NA	NA
AXP79186.1\|83174_85334_-	hypothetical protein	A0A1B0WND9	Flavobacterium_phage	1.9e-171	48.4

DBSCAN-SWA_2

118741 : 125881

Paenibacillus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXP79237.1\|118741_119287_-	Putative metal-dependent hydrolase YfiT	D0R7I3	Paenibacillus_phage	1.4e-22	45.5
AXP79238.1\|119405_120338_-	putative peptidyl-prolyl cis-trans isomerase	A0A1V0SCU1	Indivirus	2.2e-23	42.5
AXP79239.1\|120525_122730_-	ATP-dependent DNA helicase RecQ	A0A2K9L3P7	Tupanvirus	2.3e-84	37.3
AXP79240.1\|122936_123902_+	Arabinose 5-phosphate isomerase KdsD	Q7Y583	Enterobacteria_phage	1.2e-21	40.6
AXP79241.1\|123901_124726_+	Sec-independent protein translocase protein TatCy	A0A1B1IVR7	uncultured_Mediterranean_phage	2.8e-22	27.7
AXP79242.1\|124718_125066_+	Alkyl hydroperoxide reductase AhpD	NA	NA	NA	NA
AXP79243.1\|125007_125130_-	hypothetical protein	NA	NA	NA	NA
AXP79244.1\|125140_125881_+	Lipopolysaccharide export system ATP-binding protein LptB	A0A2H4PQG7	Staphylococcus_phage	8.6e-23	29.4

DBSCAN-SWA_3

643251 : 651715

Staphylococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXP79727.1\|643251_644178_-	Transposase	A0A1X9I6A9	Streptococcus_phage	5.1e-25	29.4
AXP79728.1\|644253_645501_+	EcoKI restriction-modification system protein HsdS	A0A2H4PQP5	Staphylococcus_phage	2.1e-13	24.2
AXP79729.1\|645598_646759_-	Putative type-1 restriction enzyme specificity protein	A0A2H4PQP5	Staphylococcus_phage	1.2e-26	26.0
AXP79730.1\|646807_648367_-	putative type I restriction enzymeP M protein	A0A2H4PQP4	Staphylococcus_phage	8.3e-161	55.8
AXP79731.1\|648963_649503_+	hypothetical protein	NA	NA	NA	NA
AXP79732.1\|650205_650598_+	Single-stranded DNA-binding protein	A0A1S5SAJ4	Streptococcus_phage	1.7e-09	38.1
AXP79733.1\|650641_651715_+	hypothetical protein	A0A249XNN6	Brevibacterium_phage	9.5e-31	32.2

DBSCAN-SWA_4

1699073 : 1706454

Escherichia_phage(28.57%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXP80586.1\|1699073_1700432_-	Glycerol-3-phosphate cytidylyltransferase	A0A1V0SGE7	Hokovirus	8.9e-18	42.2
AXP80587.1\|1700508_1701549_-	GDP-L-fucose synthase	D1LW79	Prochlorococcus_phage	5.5e-92	50.1
AXP80588.1\|1701554_1702673_-	GDP-mannose 4-2C6-dehydratase	M4QRT5	Synechococcus_phage	1.4e-125	65.0
AXP80589.1\|1702685_1703522_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	1.3e-30	34.7
AXP80590.1\|1703530_1704076_-	dTDP-4-dehydrorhamnose 3-2C5-epimerase	A0A218MN57	uncultured_virus	7.7e-29	44.0
AXP80591.1\|1704081_1704936_-	Glucose-1-phosphate thymidylyltransferase 1	I7I009	Enterobacteria_phage	1.3e-94	59.0
AXP80592.1\|1704984_1705329_-	hypothetical protein	NA	NA	NA	NA
AXP80593.1\|1705410_1706454_-	dTDP-glucose 4-2C6-dehydratase	A0A1D7XFE8	Escherichia_phage	2.5e-84	50.5

DBSCAN-SWA_5

1881087 : 1890492

Ralstonia_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXP80737.1\|1881087_1881321_-	Acyl carrier protein	B2ZXV3	Ralstonia_phage	1.7e-06	38.1
AXP80738.1\|1881685_1882258_+	Phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.4e-17	31.1
AXP80739.1\|1882292_1882943_+	Ribonuclease H	R4TF97	Phaeocystis_globosa_virus	6.0e-12	30.9
AXP80740.1\|1883044_1883971_+	putative sugar kinase YdjH	NA	NA	NA	NA
AXP80741.1\|1884096_1885995_+	Amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	6.0e-12	23.7
AXP80742.1\|1886622_1887231_-	Superoxide dismutase	Q56AR7	Bacillus_thuringiensis_phage	4.5e-62	58.9
AXP80743.1\|1887360_1890492_+	ATP-dependent helicase/nuclease subunit A	A0A068EQC7	Bacillus_phage	7.1e-10	25.2

DBSCAN-SWA_6

2717214 : 2724606

Lactococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXP81410.1\|2717214_2718342_-	putative peptidyl-prolyl cis-trans isomerase	A0A2H4UTF4	Bodo_saltans_virus	2.8e-25	44.7
AXP81411.1\|2718343_2718892_-	FKBP-type peptidyl-prolyl cis-trans isomerase	NA	NA	NA	NA
AXP81412.1\|2718884_2719904_-	Bifunctional oligoribonuclease and PAP phosphatase NrnA	NA	NA	NA	NA
AXP81413.1\|2720078_2720498_+	Nucleoside diphosphate kinase	A0A0M5KH58	Mollivirus	2.6e-08	34.8
AXP81414.1\|2720605_2720797_-	Cold shock protein ScoF	A0A218MMZ6	uncultured_virus	2.2e-07	50.7
AXP81415.1\|2721156_2721348_-	Cold shock-like protein CspC	Q9AZD3	Lactococcus_phage	1.3e-07	46.9
AXP81416.1\|2721504_2721696_-	Cold shock-like protein CspC	Q9AZD3	Lactococcus_phage	2.0e-08	48.4
AXP81417.1\|2721793_2722090_-	hypothetical protein	NA	NA	NA	NA
AXP81418.1\|2722128_2723208_-	DNA replication and repair protein RecF	NA	NA	NA	NA
AXP81419.1\|2723348_2724119_+	Tetratricopeptide repeat protein	NA	NA	NA	NA
AXP81420.1\|2724120_2724606_+	6-2C7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	1.9e-18	38.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP022985

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection