CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP029607	Actinosynnema pretiosum subsp. pretiosum strain ATCC 31280 chromosome, complete genome	6 crisprs	cas3,DinG,DEDDh,csa3,cas4,WYL,cas6e,RT	0	5	1	0

1. CP029607

CRISPR-Cas detection and classification

Crispr_ID: CP029607_1

• CRISPR_ID: CP029607_1
• CRISPR_location: 1940717-1940796
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP029607_1

Consensus_repeat	Method
GACCGCGGCGCGCGGAACGGCCCCGG	CRISPRCasFinder

spacers of CP029607_1

>1.1|1940743|28|CP029607|CRISPRCasFinder
ATTCGGGGGCACCCCCGGCATCGGGGGC

CRISPR arrays and Neighbor proteins around CP029607_1

CRISPR arrays

The CRISPR arrays of CP029607_1

>merge|CP029607|1|1940717-1940796|CRISPRCasFinder
GACCGCGGCGCGCGGAACGGCCCCGGATTCGGGGGCACCCCCGGCATCGGGGGCGACCGCGGCGCGCGGAACGGCCGCGG

>CP029607|1|1|1940717-1940796|CRISPRCasFinder
GACCGCGGCGCGCGGAACGGCCCCGG	ATTCGGGGGCACCCCCGGCATCGGGGGC
GACCGCGGCGCGCGGAACGGCCGCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP029607.1|AXX29079.1|1931007_1931712_+|Hydroxyacylglutathione-hydrolase	unknown	unknown	gnl|CDD|293792
CP029607.1|AXX29091.1|1949154_1950300_+|putative-alkaline-serine-protease	unknown	unknown	gnl|CDD|173790
CP029607.1|AXX29084.1|1937399_1938257_+|Radical-SAM-domain-protein	unknown	unknown	gnl|CDD|197642
CP029607.1|AXX29096.1|1955656_1956871_-|Glycosyl-transferase	unknown	unknown	gnl|CDD|133031
CP029607.1|AXX29089.1|1946149_1947310_+|Isovaleryl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|224871
CP029607.1|AXX29088.1|1944116_1946153_+|Methylcrotonyl-CoA-carboxylase-biotin-containing-subunit	unknown	unknown	gnl|CDD|227111
CP029607.1|AXX29086.1|1938888_1939476_+|Transcriptional-regulator,-TetR-family	unknown	unknown	gnl|CDD|366102
CP029607.1|AXX29095.1|1954239_1955403_+|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX29078.1|1929946_1930792_-|putative-peptidyl-prolyl-cis-trans-isomerase-B	unknown	unknown	gnl|CDD|238194
CP029607.1|AXX29080.1|1931721_1932987_+|Histidyl-tRNA-synthetase	unknown	unknown	gnl|CDD|234586
CP029607.1|AXX29093.1|1951934_1953713_+|Aspartyl-tRNA-synthetase	unknown	unknown	gnl|CDD|234775
CP029607.1|AXX29087.1|1942519_1944115_+|Methylcrotonyl-CoA-carboxylase-carboxyl-transferase-subunit	unknown	unknown	gnl|CDD|178415
CP029607.1|AXX29090.1|1947350_1948286_-|hypothetical-protein	unknown	unknown	gnl|CDD|237361
CP029607.1|AXX29081.1|1932983_1933688_+|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX29085.1|1938370_1938748_+|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX29094.1|1953985_1954201_+|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX29077.1|1927547_1929776_+|GTP-pyrophosphokinase	unknown	unknown	gnl|CDD|223394
CP029607.1|AXX29082.1|1934568_1935525_-|Spermidine-synthase	unknown	unknown	gnl|CDD|223498
CP029607.1|AXX29092.1|1950566_1951760_+|Alkaline-serine-exoprotease-A-precursor	unknown	unknown	gnl|CDD|173790
CP029607.1|AXX29083.1|1935806_1937411_-|YibE/F-like-protein	unknown	unknown	gnl|CDD|377940

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP029607.1|AXX29079.1|1931007_1931712_+|Hydroxyacylglutathione-hydrolase	gnl|CDD|293792	cd06262, metallo-hydrolase-like_MBL-fold, mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases which can catalyze the hydrolysis of a wide range of beta-lactam antibiotics, hydroxyacylglutathione hydrolases (also called glyoxalase II) which hydrolyze S-d-lactoylglutathione to d-lactate in the second step of the glycoxlase system, AHL lactonases which catalyze the hydrolysis and opening of the homoserine lactone rings of acyl homoserine lactones (AHLs), persulfide dioxygenase which catalyze the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria, flavodiiron proteins which catalyze the reduction of oxygen and/or nitric oxide to water or nitrous oxide respectively, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J which has both 5'-3' exoribonucleolytic and endonucleolytic activity and ribonuclease Z which catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors, cyclic nucleotide phosphodiesterases which decompose cyclic adenosine and guanosine 3', 5'-monophosphate (cAMP and cGMP) respectively, insecticide hydrolases, and proteins required for natural transformation competence. The diversity of biological roles is reflected in variations in the active site metallo-chemistry, for example classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, human persulfide dioxygenase ETHE1 is a mono-iron binding member of the superfamily; Arabidopsis thaliana hydroxyacylglutathione hydrolases incorporates iron, manganese, and zinc in its dinuclear metal binding site, and flavodiiron proteins contains a diiron site.	6.10161e-71
CP029607.1|AXX29091.1|1949154_1950300_+|putative-alkaline-serine-protease	gnl|CDD|173790	cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, Peptidase S8 family domain in ProteinaseK-like proteins. The peptidase S8 or Subtilase clan of proteases have a Asp/His/Ser catalytic triad that is not homologous to trypsin. This CD contains several members of this clan including: PCSK9 (Proprotein convertase subtilisin/kexin type 9), Proteinase_K, Proteinase_T, and other subtilisin-like serine proteases. PCSK9 posttranslationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR. Characterized Proteinases K are secreted endopeptidases with a high degree of sequence conservation. Proteinases K are not substrate-specific and function in a wide variety of species in different pathways. It can hydrolyze keratin and other proteins with subtilisin-like specificity. The number of calcium-binding motifs found in these differ. Proteinase T is a novel proteinase from the fungus Tritirachium album Limber. The amino acid sequence of proteinase T as deduced from the nucleotide sequence is about 56% identical to that of proteinase K.	6.20567e-109
CP029607.1|AXX29084.1|1937399_1938257_+|Radical-SAM-domain-protein	gnl|CDD|197642	smart00306, HintN, Hint (Hedgehog/Intein) domain N-terminal region. Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.	1.36639e-05
CP029607.1|AXX29096.1|1955656_1956871_-|Glycosyl-transferase	gnl|CDD|133031	cd04188, DPG_synthase, DPG_synthase is involved in protein N-linked glycosylation. UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.	3.35661e-77
CP029607.1|AXX29086.1|1938888_1939476_+|Transcriptional-regulator,-TetR-family	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	4.05975e-07
CP029607.1|AXX29089.1|1946149_1947310_+|Isovaleryl-CoA-dehydrogenase	gnl|CDD|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	7.23483e-82
CP029607.1|AXX29088.1|1944116_1946153_+|Methylcrotonyl-CoA-carboxylase-biotin-containing-subunit	gnl|CDD|227111	COG4770, COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism].	0
CP029607.1|AXX29078.1|1929946_1930792_-|putative-peptidyl-prolyl-cis-trans-isomerase-B	gnl|CDD|238194	cd00317, cyclophilin, cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug cyclosporin (CsA). Immunosuppression in vertebrates is believed to be the result of the cyclophilin A-cyclosporin protein drug complex binding to and inhibiting the protein-phosphatase calcineurin. PPIase is an enzyme which accelerates protein folding by catalyzing the cis-trans isomerization of the peptide bonds preceding proline residues. Cyclophilins are a diverse family in terms of function and have been implicated in protein folding processes which depend on catalytic /chaperone-like activities. This group contains human cyclophilin 40, a co-chaperone of the hsp90 chaperone system; human cyclophilin A, a chaperone in the HIV-1 infectious process and; human cyclophilin H, a component of the U4/U6 snRNP, whose isomerization or chaperoning activities may play a role in RNA splicing. .	6.72815e-51
CP029607.1|AXX29080.1|1931721_1932987_+|Histidyl-tRNA-synthetase	gnl|CDD|234586	PRK00037, hisS, histidyl-tRNA synthetase; Reviewed.	0
CP029607.1|AXX29093.1|1951934_1953713_+|Aspartyl-tRNA-synthetase	gnl|CDD|234775	PRK00476, aspS, aspartyl-tRNA synthetase; Validated.	0
CP029607.1|AXX29087.1|1942519_1944115_+|Methylcrotonyl-CoA-carboxylase-carboxyl-transferase-subunit	gnl|CDD|178415	PLN02820, PLN02820, 3-methylcrotonyl-CoA carboxylase, beta chain.	0
CP029607.1|AXX29090.1|1947350_1948286_-|hypothetical-protein	gnl|CDD|237361	PRK13355, PRK13355, bifunctional HTH-domain containing protein/aminotransferase; Provisional.	0.000446417
CP029607.1|AXX29077.1|1927547_1929776_+|GTP-pyrophosphokinase	gnl|CDD|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
CP029607.1|AXX29082.1|1934568_1935525_-|Spermidine-synthase	gnl|CDD|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	3.82632e-23
CP029607.1|AXX29092.1|1950566_1951760_+|Alkaline-serine-exoprotease-A-precursor	gnl|CDD|173790	cd04077, Peptidases_S8_PCSK9_ProteinaseK_like, Peptidase S8 family domain in ProteinaseK-like proteins. The peptidase S8 or Subtilase clan of proteases have a Asp/His/Ser catalytic triad that is not homologous to trypsin. This CD contains several members of this clan including: PCSK9 (Proprotein convertase subtilisin/kexin type 9), Proteinase_K, Proteinase_T, and other subtilisin-like serine proteases. PCSK9 posttranslationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR. Characterized Proteinases K are secreted endopeptidases with a high degree of sequence conservation. Proteinases K are not substrate-specific and function in a wide variety of species in different pathways. It can hydrolyze keratin and other proteins with subtilisin-like specificity. The number of calcium-binding motifs found in these differ. Proteinase T is a novel proteinase from the fungus Tritirachium album Limber. The amino acid sequence of proteinase T as deduced from the nucleotide sequence is about 56% identical to that of proteinase K.	3.21539e-120
CP029607.1|AXX29083.1|1935806_1937411_-|YibE/F-like-protein	gnl|CDD|377940	pfam07907, YibE_F, YibE/F-like protein. The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE and YibF. Most of the members of this family are annotated as being putative membrane proteins, and in fact the sequences contain a high proportion of hydrophobic residues.	9.27411e-94

Protein sequences

>CP029607.1|AXX29086.1|1938888_1939476_+|Transcriptional-regulator,-TetR-family
MATETRRRQVDRSADTRRRLLAATVECLVEHGWAGTTTTVVAERAGVSRGGQLHHFRTRGELVAAAVEHLGAESVAHLRRLAERVEGGPVAVVELIAEFYASDRFAAALELWVAARTDPALRIAVVPLEAALGRETHRLAVELLGADEAKPGVREAVQITLDLARGLALANQLTDDGKRRRRIARHWAGMLEAVL
>CP029607.1|AXX29085.1|1938370_1938748_+|hypothetical-protein
MTFTPSDEDITSVLDWFARWDALCAERDLEALADMAMFPVNAVTDGSAESWDRERFLRDFGAALGDGGLELRSTRSPLFLSADLVFVVTDAEFGSGAEAGSMRYGDLLVRKDGRWLYQTMAQGGW
>CP029607.1|AXX29084.1|1937399_1938257_+|Radical-SAM-domain-protein
MGAHCLAADTPALLADGSTRPIGALRPGDRVFGTRDGRYSPTVVIARSTATRPAYRVSLAGGTQVVSGAGNRLRTDLGWRALTPGGERLHLTRGTRVQGTGRFAAPPERNRDYRLGYLWGAVRGGPPVVPEVLARVREFAGGGEPRERDLVEWPTQLGDDWAKGFLAGVFDVRGAAVGGQVVLSSPDSAVFEAVVVALLRLRVPHSVEVRGVRVTGAPAERLRFLHLVGPVLARPAVLEGVQVGGAPALGVVSVESLGIEVEMGAVTTESGDLVVNGLIACADGR
>CP029607.1|AXX29083.1|1935806_1937411_-|YibE/F-like-protein
MRAHAPAHPVFMHNYIRTRVLMIVKPSPGRPLHPLSRTTTGTIATVRATDHLPAHGHGHGHTPAGPASAPVRRLLLVLLLPLVLATVAGALVLYPFGQEIKTGSEVGINHTPVRGEATKVEKGPCAVGLPEGTPVPQDEGCFLVTVRMTDGAAADRDVTIPVPDQPTSPTVSAGDEVVLSYSGTEPTSPLSYQLVDFQRGLPLSLLALLFVGAVLVLGRWHGLRALGALGLSFVVLALFVLPAILAGEDPLWVAVVGAGLIMFVVLYVSHGVSARTSTAVLGTLVSLALIGALGALFGAGARLTGLDEQTANLVTILGHGIDTRGLLLAGTIIGALGVLDDVTVTQTSAVWELRAANPSMGFGQLYAAGARIGRDHLSSVVNTLVMAYAGAALPLMLSFALSGQDLGTILTAQDVAQEIVQTLVGSIGLVAAVPVTTALAAFVAAREEVVAGDDEEPAPAEDDVEDGVEEDEDDEPVAAERAPEPTPPPARSRIAGDLRYGYDPSKEWERVSPRSARPPAPPRRARPGRRGFDD
>CP029607.1|AXX29082.1|1934568_1935525_-|Spermidine-synthase
MFTSAGAYSCPAPDPLTPHAGSTGRVADNPGVGRARRTDDTITREVDSGIAELVPDPYYDNGWTLLLNGTPQSHVDLDDPANLVFEYVRRIAHLADLLADEGEPLRAVHLGGGAMSLPRYIAATRPGSSQQVVEIDEALVDLVRGVLPLRRDWRVRVRRGDARAVLAKAPEDTFDLIVTDAFAGARTPAHLTSREYVELAARALNARGVYSSNIGDGGDRAFARGQIATIRSVFRNVCVIAEPAVFKGRRFGNFVIAASNQDLPLAELIRRTAGDPFPGQVEHGESLTRFTGGARPVTDETATRSPEPPQGTWGISED
>CP029607.1|AXX29081.1|1932983_1933688_+|hypothetical-protein
MSDGDGVTGAAGAPGSSGSSGAPGPSGPPERIPLDLLDPATVRKRSRMVAVGALIVAGAFGGLVGLLGGQTAGLVTAAIFGVPLLLLAVSEARRRVWLEGSVLSVRAYGTRVVDLKTADSLDVLVTDTRGTRTVGLFARGGHKAINLALALYAGTGGRELGIYPLRTLADVLASRGDAQSLALSELLVAQLRAEARGAAAADRPLYRLGSLAPSGKLAQKLKPEAISRFVAQLD
>CP029607.1|AXX29080.1|1931721_1932987_+|Histidyl-tRNA-synthetase
MTTPFAAPKGVPDYFPPNSAAFTAVRSALLGATARAGYGYIELPVFEDTALFARGVGESTDVVSKEMYTFTDRGGRSITLRPEGTAGVMRAVIEHGLDRGQLPVKLAYAAQFFRAEQPQAGRYRQFHQVGVEAIGVDDPALDAEVIAIADEGFRALGLTGYRLELTSLGDATCRPQYREKLQAFLAKLPLDEDTRRRAEINPLRVLDDKRPEVRELVAEAPLMLDNLSPETLEHYERVKAHLGDLGVKYVENPRMVRGLDYYTKTTFEFVHDGLGAQSGIGGGGRYDGLMAQLGGQELSGVGFGLGVDRALLACQVEGLAVGDVTRCDVYGVPLGDAARSRLVGIGAPLRAAGVRYDMAYGGKGLKGAMKGADRSGARFALVLGERDIEAGVVQLKELATGEQREVPLDDVVTEVRGALGR
>CP029607.1|AXX29079.1|1931007_1931712_+|Hydroxyacylglutathione-hydrolase
MLVIGFPTGALQANCYLVASEAGGACVVVDPGQDALEPIAEAVREHRLSPVAVLLTHGHFDHSYSVAPVCDGDDIPAWVHPADRAMLSDPLSGVSAETRAFFGGRLEMREPREVRELSDGAELDLAGLRFTVDHTPGHTGGSVMFRSGVEEGGRLVLSGDTLFAGSIGRTDLPGGDHGAMLGSLRRKVLTLDDDVVVLPGHGPTTTIGRERASNPFLTELVRDDDAPAAQRRGL
>CP029607.1|AXX29078.1|1929946_1930792_-|putative-peptidyl-prolyl-cis-trans-isomerase-B
MPNNAQRREQAKRKLERQITRRVERDKRRRVVAVISTAVVVLLVAGGVYFLATYDFGSDTTDTAASSSAAPQSDKPASIPTELHAAIKRPTPLAPQVSCEYAAEGESAKPGAKAPENGQVSSEGTVAATLGTSIGDLKLTLDRSLAPCTVNSFVSLVKQGYFNDTTCHRLTTQGIQVLQCGDPTGTGTGGPGYKFNDEVFPEITYGRGVLAMANSGPNTNGSQFFIVYGDASSLPASYTVFGTVDADGLKLVDEVANAGTDSGAGDGKPNTPVDIKTATTA
>CP029607.1|AXX29077.1|1927547_1929776_+|GTP-pyrophosphokinase
MRARLARRITAQRAAPVKQVLEPLAAVHRDLHPNADLGLLQRAYDVAEEKHRPQRRKSGDPYITHPLAVATILAELGMDTTTLVAALLHDTVEDTDYSLDQLRDDFGTVVALLVDGVTKLDKVKLGAAAEAETIRKMVIAMAKDPRVLVIKLADRLHNMRTMRFLPPEKQARKARETLEVLAPLAHRLGMATVKWELEDLAFAILQPKKYDEIVRLVANRAPSRDTYLSGVINELSGHLEGARLTAKVEGRPKHYYSINQKMIVRGRDFDDIHDLVGVRIQVDEVRDCYAAMGVVHALWQPMPGRFKDYIAQPRFGVYQSLHTTVIGPDGKPLEVQIRTYDMHRTAEYGIAAHWRYKETKGSHRGKSVEVDEMAWMRQLLDWQREAADPGEFLESLRFDLAAREIFVFTPKGDVVTLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEVVEIFTSKAEGAGPSRDWLSFAQSPRAKAKIKQWFAKERKEEAIEVGKDAIAKEVRRVGLPLQRLVSADAMGALAKELHYPDVSALYAAVGEGHTSARHVVQRLVAQLGGVDHAEDELAERSTPSTVARRRVTGDAGVIVKDSSDVWVKLARCCTPVPGDDILGFVTRGGGVSVHRTDCTNADELLKTPERLLDVEWAPSSSSVFLVAIQVEALDRHRLLSDVTKVLADEKVNILSASVTTSRDRVAVSRFSFEMGDPKHLGHVLKAVRSVEGVYDVYRVTSAS
>CP029607.1|AXX29087.1|1942519_1944115_+|Methylcrotonyl-CoA-carboxylase-carboxyl-transferase-subunit
MTTLTSAVDPDSAEHRANREAMLARLADLEAEHAKVLAGGGPKYVDRHRARGKLLARERIELLLDLDAPFLELSPLAAWGTEHPLGAGLVTGVGVVSGVECVITANDATVRGGSTNPWSLRKSLRANDIAAQNRLPLIGLVESGGADLTSQSEIFIPGGRAFRDLTRLSAAGIPTISTVFGNATAGGAYVPGLSDHTILVRDRAKVFLGGPPLVRMATGEVADDESLGGADMHGSTSGLADHVARDEVDALRLTRRVVARLNRRKLGRAPGPVDEPLHDPEDLLGLVPTDLRVPFDPREVIARLVDGSRFDEFKPDYGTSLVTGWADLHGYPVGVLANARGVLFSQEAQKAAQFIQLANTSATPLLFLQNTTGYMVGASYEQGGIVKHGSMMINAVANSRVPHLTVVMGASYGAGNYGMCGRAYDPRFLFSWPSAKSAVMGPAQLAGVLSIVARQAAAARGVPYDEDGDAAMRRAVEEQVEAQSLAPFLSGRLYDDGVIDPRDTRTVLGLCLSAAHSGEVVGADRFGVFRM
>CP029607.1|AXX29088.1|1944116_1946153_+|Methylcrotonyl-CoA-carboxylase-biotin-containing-subunit
MLMIGRLLVANRGEIARRVIRACREAGVSPVAVHADPDAGEPHVREADASVRLPGEHPADTYLRADLLVAAALASGADAVHPGYGFLSENAAFARAVLDAGLTWVGPDPEVIAAMGDKVAAKRVMREAGVPVLPDLDPVTADRFPLLVKASAGGGGRGMRVVREAAGLAGQVDAARREAASAFGDGTVFCEPLLEGARHVEVQVLADRRGTVWALGERECSIQRRHQKLVEETPSPAVDDRLRAELCAAAVRAARAIGYTGAGTVEFLLDDSGAFHFLEVNTRLQVEHPVTELTWGVDLVAWQLAIAEGAQLPDAPPAPSGHAIEVRLCAEDPEREWRPSHGVVRRFHVPGDVRVDSGVEAGSAVGVRYDPLLAKVIAHGPTRAAAVRKLAAALERAELHGVTTNRDLLVAVLRHPAFGRGDTHTGFLEQHRADLLGARPVDVRHAALAAALARSAHRARALPAGWRNLPSQPVRVAFEHRGERVEVDYLRTRDGITTGLDVEVVAAWPDVVRLRRGGVETAWPVTHYPPPDPSGEPGPGDRVEVGPVTLIPLPRHPAPERRTPRGTTTAPMPGVVVRVEVAEGATVAEGELLLVLEAMKVEHRVRAELAGVVTAVPVAEGRSVAEGDVLVVLEPAGPAVTAGSATPADPATPADPATPADPATPADPATPADPEEQQ
>CP029607.1|AXX29089.1|1946149_1947310_+|Isovaleryl-CoA-dehydrogenase
MTAFTESAERADLRAAVAAFASRYGERYFLDKARSGGKTHELWAEAGKLGYLGVAVPEEHGGGGGGIGDLAAVCEELAAAGCPMLLLVVSPAICATVITRFGTEAQKARWLPGFADGATKMAFAITEPEAGSNAHRLTTTIRRDGDDWLLTGSKHYISAVDEADAVLVVARHVDASGQRLAPSLVVVPTDAPGFTRHEIGMELVSPEKQFTCFFDEVRLPADALVGDPSAGLDQLFAGLNPERIMAASYATGVARRAIAKAADYARTRTVWDVPIGAHQGLAHPLAQVAVQVELARLMTQKAAALYDAGRDREAGESANMAKYAAGEAVAAAVDQAIQVHGGNGLSTEHGLGALLTASRLSRIAPVSREMILNFVAQHTLRLPRSY
>CP029607.1|AXX29090.1|1947350_1948286_-|hypothetical-protein
MGDPGRIGGGGDPFACALRTAIRAKGLSLERIQHRLRGRGSTVSIAALSYWQSGRRRPERPDSLTALAHLEEILDLGEGALRSLLGPPRPRGKARPRPVPASSPLGWVADASASEPMAELLADVDTSSDHDLTRLSLRDQVELAMDGSTRRVRSRQVLRAERGGVDRVLLGYDTRLPGDPLPVIGTLRGCSLGRVATDPRNGLMIAELLFDRPLRRGERTAVEYELIYVAPHHPTFDNTHTRRFRHTVKEYVLEVRYDSRCRPARCEQFTSGLTDVEPAEVRETPVDAWGYAYAVAVDFGPGVVGLRWEWA
>CP029607.1|AXX29091.1|1949154_1950300_+|putative-alkaline-serine-protease
MSRNHAPLLTAALAVVALATPASAEEGRVLSAASPDAIPGSFLVQLKPTASAADFDGSGVRAPGVRAERVLEGAFHGFTARLTDRQARRLAAHPDVELVEQDQVVRPYAVQTNPPWHLDRLDQVALPLNAQYGYTTTGQGTRAYVVDTGVRITHQQFGGRICAGWDVVENDEIGQDLNGHGTHVAGLIAGSTHGVAKSASICPVRVFDANGSGTTAGVVQAVNWIRLNAVKPATANFSLGGAASTALDTAVQALITSGVTASVTAGGSNGDAANHSPARVAAAITSGATTNTDARAPYSNYGSIVDVYAPGQSITSAWHTSDTATNTLSGTSMSTAQVTGVANRYLHANPTATPAQVHGAIVSWATPQPWGGKLLHWPPQL
>CP029607.1|AXX29092.1|1950566_1951760_+|Alkaline-serine-exoprotease-A-precursor
MLESRHHRYLAGVGTAALLMGVMATPAGAATGEILSADAEKKVQNSFIVKLKDGYTAASSTEAVTAKLTSRFGGQVKHTYSSINGFAVSLSESAAKRLAADPSVEYVEQDQVFSIQATQTNPPSWGLDRIDQRNLPLNSSYSYTSTGSGVRAYVIDTGVRIAHNAFGGTAVNGYDAVDGDNVAQDGNGHGTHVAATVSSASYGVSKAAQIVAVRVLDNAGSGTTAGVVAGINWVTNNHVKPAVANMSLGGGASTSLDNAVASSISAGVTYAVAAGNSNANASSYSPARVASALTVGATTSTDARASYSNYGAVVDIFAPGSSITSAWSTSNTATNSISGTSMASPHVAGAAARYLSTTPSATPAQVATYLTGQATTGKVTSPGTGSPNRLLYLAPTA
>CP029607.1|AXX29093.1|1951934_1953713_+|Aspartyl-tRNA-synthetase
MMRTHEAGTLRAEHAGQSVTLTGWVARRRDHGGVIFIDFRDASGVAQVVFREGEMAERAHRLRSEFVLKVVGEVSRRPEGSENPDLPTGAIEVYASEFEVLNESAPLPFQLDEHLEVGEEARLRHRYLDLRRSGPAKAMRLRSEANRIAREVLHSERFVEVETPTLTRSTPEGARDFLVPARLRPGSWYALPQSPQLFKQLLMVGGLERYYQIARCYRDEDFRADRQPEFTQLDIEMSFVEQDDVIALGEKIITALWKELGDHDVAQPFRRISYAEAMAKYGSDKPDLRFGLELTELTEYFKDTPFRVFQAPYVGAVVMPGGASQPRRTLDAWQEWAKQRGAKGLAYVLVGEDGTLGGPVAKNLTDAERDGLAKAVGANPGDCVFFGAGDVDGARALLGAARVEIANRVGLIEEGSWSFVWVVDFPMFEAVDKIGDDVAVGSGKWTALHHAFTSPTPEWVDNFETDPGNALAYAYDIVCNGNEIGGGSIRIHRADVQQRAFDVMGIGAEEAQEKFGFLLDAFKFGAPPHGGIAFGWDRITMLLSGADSIREVIAFPKSGGGYDPLTAAPAPITPQQRKEAGVDAKPAAPKQA
>CP029607.1|AXX29094.1|1953985_1954201_+|hypothetical-protein
MRAACGTGCGACLPPPGDPTIPPGLWEPGPRRWHRVRDSVINEWWPPCGTRTTVTVPERVLSHRRHCAQQG
>CP029607.1|AXX29095.1|1954239_1955403_+|hypothetical-protein
MDVEPGLLDAVRAAETVLSSRFGARVTLADPENLGGAGRSTVARVRVASTPFSLPRTLVVKRYPEQVADRDPFAHEAASHKLLTALPAEERATPELFAQDTRKRLVVLEDLGKAPRLAEKLLGSDARVAERGLLSWAHAMGRLHATTAGRDADFDALMRRQGSQCCADPVAVDLHVALAGLPDLLREVLGVDTPTSVLEFADHAVRGFGTSRHRAFSPSTSCPDNHLVTGRGVRFLDFEGGCVRDIVFDAACLRVPFPSCWCAYGLPPGMSEAMLAAWRAEVSSVWPDLDDDDVFLPRLLEAQLLWLWLGTWRGLPSLEGQGQNGHGKRLDVPPRIQILTSRWVRLRTEALGLGVKHVAAFAEELVDALVARHGSSALELALYPAFR
>CP029607.1|AXX29096.1|1955656_1956871_-|Glycosyl-transferase
MLDVVVPVYNEERALASSVRVLHAHLTARFPHSFRITIADNASTDTTAQVADRLALEFGNVVAVHLPQKGRGRALNAVWLASDAQVLAYLDVDLSTDLAALPPLVAPLISGHSDVAIGSRLARGARVVRGPKREFVSRCYNLVLRASLSAGFTDAQCGFKAIRADVARRILPHVQDTGWFFDTELLVLAERAGARIHEVPVDWVDDPDSSVDIVATALADLRGVARLGKGLLSGGLPIAQLSAQLGRAPLEPATPGAPPGLLRQLVRFAVVGVASTLAYLLLFALLRDGVGAQWANLVALLVTAVANTSVNRRFTFGVRGKRGAGRHQLEGLLVFALGLAFTGGALALAHGVADPGGHAELVAVVGGNLLATVARFLLLRNWVFRGNGKKVGNAEQPRVGVGAS

Crispr_ID: CP029607_2

• CRISPR_ID: CP029607_2
• CRISPR_location: 3784031-3784114
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP029607_2

Consensus_repeat	Method
GCTCTCGGATCGGATCGCGACAC	CRISPRCasFinder

spacers of CP029607_2

>2.1|3784054|38|CP029607|CRISPRCasFinder
CTGCAGACCGCGCGTGTCCGGGCCGGTCGTCGGTGTGC

CRISPR arrays and Neighbor proteins around CP029607_2

CRISPR arrays

The CRISPR arrays of CP029607_2

>merge|CP029607|2|3784031-3784114|CRISPRCasFinder
GCTCTCGGATCGGATCGCGACACCTGCAGACCGCGCGTGTCCGGGCCGGTCGTCGGTGTGCGCCCTCGGATCGGATCGCGACAC

>CP029607|2|2|3784031-3784114|CRISPRCasFinder
GCTCTCGGATCGGATCGCGACAC	CTGCAGACCGCGCGTGTCCGGGCCGGTCGTCGGTGTGC
GCCCTCGGATCGGATCGCGACAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP029607.1|AXX30557.1|3775192_3775939_-|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX30566.1|3784273_3785155_-|oxidoreductase	unknown	unknown	gnl|CDD|176191
CP029607.1|AXX30569.1|3786383_3788636_+|ABC-transporter,-transmembrane-region	unknown	unknown	gnl|CDD|224055
CP029607.1|AXX30574.1|3795436_3800230_+|Malonyl-CoA-acyl-carrier-protein-transacylase	unknown	unknown	gnl|CDD|225858
CP029607.1|AXX30568.1|3786118_3786340_+|hypothetical-protein	unknown	unknown	gnl|CDD|319213
CP029607.1|AXX30556.1|3773981_3775196_-|protein-of-unknown-function-DUF955	unknown	unknown	gnl|CDD|225412
CP029607.1|AXX30563.1|3782334_3782532_-|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX30561.1|3781144_3781771_+|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX30564.1|3782754_3783138_+|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX30570.1|3788644_3789895_+|Na+/H+-antiporter	unknown	unknown	gnl|CDD|215608
CP029607.1|AXX30571.1|3789993_3790569_-|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX30560.1|3779450_3779795_+|Anti-sigma-F-factor-antagonist-(spoIIAA-2),-Anti-sigma-B-factor-antagonist-RsbV	unknown	unknown	gnl|CDD|132914
CP029607.1|AXX30573.1|3792049_3795226_+|regulatory-protein,-LuxR	unknown	unknown	gnl|CDD|197715
CP029607.1|AXX30558.1|3776195_3778412_+|hypothetical-protein	unknown	unknown	gnl|CDD|225272
CP029607.1|AXX30567.1|3785225_3785822_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
CP029607.1|AXX30575.1|3800239_3810259_+|Malonyl-CoA-acyl-carrier-protein-transacylase	unknown	unknown	gnl|CDD|225858
CP029607.1|AXX30559.1|3778541_3779339_+|Endo-1,4-beta-xylanase-A-precursor	unknown	unknown	gnl|CDD|238871
CP029607.1|AXX30572.1|3790813_3791860_-|O-methyltransferase,-family-2	unknown	unknown	gnl|CDD|366359
CP029607.1|AXX30565.1|3783267_3783981_+|Methionine-ABC-transporter-ATP-binding-protein	unknown	unknown	unknown
CP029607.1|AXX30562.1|3781857_3782211_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP029607.1|AXX30573.1|3792049_3795226_+|regulatory-protein,-LuxR	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	4.06013e-15
CP029607.1|AXX30566.1|3784273_3785155_-|oxidoreductase	gnl|CDD|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	7.55071e-89
CP029607.1|AXX30574.1|3795436_3800230_+|Malonyl-CoA-acyl-carrier-protein-transacylase	gnl|CDD|225858	COG3321, COG3321, Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	0
CP029607.1|AXX30568.1|3786118_3786340_+|hypothetical-protein	gnl|CDD|319213	pfam17195, DUF5132, Protein of unknown function (DUF5132). Proteins in this family are uncharacterized, but have been identified as members of a gene cluster for the synthesis of Ansamitocin.	1.03905e-08
CP029607.1|AXX30556.1|3773981_3775196_-|protein-of-unknown-function-DUF955	gnl|CDD|225412	COG2856, COG2856, Predicted Zn peptidase [Amino acid transport and metabolism].	2.94403e-29
CP029607.1|AXX30569.1|3786383_3788636_+|ABC-transporter,-transmembrane-region	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	2.74295e-132
CP029607.1|AXX30570.1|3788644_3789895_+|Na+/H+-antiporter	gnl|CDD|215608	PLN03159, PLN03159, cation/H(+) antiporter 15; Provisional.	4.00282e-64
CP029607.1|AXX30560.1|3779450_3779795_+|Anti-sigma-F-factor-antagonist-(spoIIAA-2),-Anti-sigma-B-factor-antagonist-RsbV	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.0897e-18
CP029607.1|AXX30558.1|3776195_3778412_+|hypothetical-protein	gnl|CDD|225272	COG2409, COG2409, Predicted drug exporters of the RND superfamily [General function prediction only].	2.96822e-95
CP029607.1|AXX30567.1|3785225_3785822_+|TetR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.97976e-11
CP029607.1|AXX30575.1|3800239_3810259_+|Malonyl-CoA-acyl-carrier-protein-transacylase	gnl|CDD|225858	COG3321, COG3321, Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	0
CP029607.1|AXX30559.1|3778541_3779339_+|Endo-1,4-beta-xylanase-A-precursor	gnl|CDD|238871	cd01833, XynB_like, SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.65588e-57
CP029607.1|AXX30572.1|3790813_3791860_-|O-methyltransferase,-family-2	gnl|CDD|366359	pfam00891, Methyltransf_2, O-methyltransferase. This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.	1.00693e-31

Protein sequences

>CP029607.1|AXX30565.1|3783267_3783981_+|Methionine-ABC-transporter-ATP-binding-protein
MPTTRTGVRVHSVVPGRQRWQVPHVRANPRAAFALETALLRRSGITHVRANPVTGRVLVLHRRSLGVTEIGAALRDAVTATSGVYAPTEGARHPFVRLGVASGVSSVLLRGVLGRAALGVPLLLVVGGVVVLAAEARRRPPGRDDVPAQLTGQRRERAQRSRPQRPRPRRGRPGDVDGSRSFSAGAAGAAGMTGAALRPEPSDPPTRHRLDRDPAPSPHTLVPTQARPLHRRVPRHR
>CP029607.1|AXX30564.1|3782754_3783138_+|hypothetical-protein
MGALAVAVLSALSWFAWFGWDTEYDLSPDGLDRTGPYQVWQGVGCAVCLLLVLVGAVVLRGVRPSFAAAGTTVGFTLGFTVSAAIISDDGLFVIGSVLAFLGAAACSALVAFGAQRFAGRGRVAPGP
>CP029607.1|AXX30563.1|3782334_3782532_-|hypothetical-protein
MVAEGHVSGGLADLGAADAGRDPVERLHECLVQFPAPADQPDQRLSLEGCSSRTAPRSPRTRWRW
>CP029607.1|AXX30562.1|3781857_3782211_+|hypothetical-protein
MRAVAVLLAGVVVALAWRGHRARGERWLVVIVECDRVPATWPGPLGALGDRVEIRNRPTARGDGIELLARPVDGRVSRAELRAALQRAKELVEGAGGRVPPPRADVDRPVGGREERR
>CP029607.1|AXX30561.1|3781144_3781771_+|hypothetical-protein
MSRAQHQPTDPDRPQTAVGTYDRYAEAERAVELLSDRHFPVDRATIVGRGLHSFEQVAAGPGSLSVASTAAGFGALIGAPLGWFFSAFGWVDPVVSTPLLIGYGALCGGLLAGVIGLVAHIVRGPGGTPVVRMRADSYDVLTDAEFAPRAAQLLDSPDAPVRRVETSTPSATIRIRQEDLPVHAQDTPLMHPPKSGRLKTDPDGHDPV
>CP029607.1|AXX30560.1|3779450_3779795_+|Anti-sigma-F-factor-antagonist-(spoIIAA-2),-Anti-sigma-B-factor-antagonist-RsbV
MTSPETHAITGEVVDGVAVVRASGEIDMANSDDLRVIATDLVDGGAQALVVDLSEVTFFASSGIAALAYLRDRVGRGLVRAVPSRSVRRSLEATAVDKLIPLHENLEEALTAAR
>CP029607.1|AXX30559.1|3778541_3779339_+|Endo-1,4-beta-xylanase-A-precursor
MGQFAEPPPRAVLPRCAWGKAVPTMGFSPRNALLSALLVLVTALLGSLLVAPGVAAAESNGGTRVMPLGDSITDGWNVPGGYRVGLWRRLVDEGYSVDFVGSGFNGPPELGDHDHEGHPGWRIDEIHARVDGWLRATRPRVVLLHIGTNDIGQDYDVANAPARMRALLDRVQLAAPSAWVFVARITPIDDPVLEARVLAFNAALPGVVADRRRVRLVDMHDGFVPGDLADGVHPSTAGYDKMAARWRAALAAVPESLPRTPVLTG
>CP029607.1|AXX30558.1|3776195_3778412_+|hypothetical-protein
MATFLHRLGLASYRNRGAVVFAWLVLLIGLGVGSAVFAGKTVTTFSIPGQESTIALERMRAEFGSGPSGASAQVVVRAPEGARITDQAIAGEVTTLVGALDKLPGVTSATNPLNPAAPVVSADQAVAYSTVTYEAQAPDITDEQRKALLDALDGARQDGLTVEVTGEATREVVGIGGPAEVIGVVVALLVLALTYGSLVTAGMNMLTAVVGVGIGALGITLLTGFVELQSTTPILAVMLGLAVGIDYALFIVTRFRHELLDGRDVPSAIAMAVGTAGSAVVTAGITVVIALTGLAVAGIPFLTEMGVAAAATVVVAVLIAVTLVPAALGFIGRRALPRRLRSGARPVDRGVYRRWATTTTRNRWPVLLVAVAALAVVAVPAFSMQTSLAQRPAEGSTQARAVEIVSEHFGPGFTGPLLVLVEGDEVARHALEVSSRAKELGDVAVVGQAQVNSDGTAALVNVVPASAPDSAETIALVDELRSAVSGVDGARVYVTGTTAVGVDVSHRLDESLPTYLVLVVGLALVLLVLVFRSLLVPVAGVLGFLLTVGASLGATTAVFQWGWLKDVVRAETTGPLMSLAPMMVTGILFGLAMDYQVFLVSRMHEAHAHGASPREAVVTGFRQAAPVVVAAAAIMFAVFAGFVPEGEATIKPIAFALAIGILVDAVVVRMVAIPAALAIMGSAAWWLPRSLRWLPVLDVEGAALERGGASAVPQQDRTEPAGAVGAHEEDAGHDVPSR
>CP029607.1|AXX30557.1|3775192_3775939_-|hypothetical-protein
MRWACLSATERALSGYSEADGLDAAWLGNTRFTYFRDRLDRVFACERYAVPSGDDNAHLDLLHAELSYRDVRTMPHLPSDLVRRSNLNHSPGWALDEHRFLLASGPFGGLDRMPWPRKSPTKQRVARRHNPEPSQPSLFDDFADEEIGGLQSVLHVADEADLTTFVVAHSLDQVSGEFELVLGRPRLNSGGGRAWHWSQDLLSLPPSGGGRRVVGAPPPQGPNQVPDARVRLRHRGEERRGDRASGER
>CP029607.1|AXX30556.1|3773981_3775196_-|protein-of-unknown-function-DUF955
MSSRTPTTDRAADAAALFDGTRLTLARHLAGLRKSDLANKVEKSPTAVAAWESGAKRPTAATVAQLALGLSVEPGFFAVRPDDVTALGSAPHFRSLRSTSQLTRDQAYAYGRLAVDIAAGLERHVEFPEPDVPSLPVAVDDRDGDGPERAARLVRRHWGVADGPVGHLIRLLENRGVLVVFSPEQTASVDAYSFDTRLRPVVVLNPIKRDYYRQRFDVAHELGHLVMHGDAEPGGRIVEEQAHRFAAELLTPADQVLDLLPATMGGDVWRSLARTKEQWGVSMQALLYRARWLGRLGDVSYRNAMTTISTRGWRRNEPGLVDAIEQPSLLPRAVELLAQEGIDEGSLVAQCRVPVDLFHTITSRTPEQPWADLAPSDGGSADHRDGPRVLSLLDRRARRAARSN
>CP029607.1|AXX30566.1|3784273_3785155_-|oxidoreductase
MKKISYSEHGGPDVLRLVDADEPSAGAGQVRIVVRAAGVNPFDWRVREGQFPVPLPAGTGLDAAGVVDQVGAGVDGVAVGDRVFGEGIETCAEFAVLTAWAHLPEGLSFEEAAGYPSVVETALRVLREVGVREGQSLLVSGASGGVGSAVLQIARDRGVRVVGTASEANQDYLRDLGATATTYGPGWVERVRALGPVDAALDLAGSGVLPDLVALTGDPRKVITIADRAAAEHGVRFSGAAHDVPAALAEAVDLITRGALRIPVERAYPLAETARAHADSQAGHARGRRVIVI
>CP029607.1|AXX30567.1|3785225_3785822_+|TetR-family-transcriptional-regulator
MTAPPGRRERKKAATRQKIADTALRLFLERGYDAVGIRDVAAEADVAVTTVFAHFDSKEALVFERDADFEHRLVRAVAERGQGDLVPALRHEVHAIVRHCTTDGAAELGELIGSSPDLRAYNEAMCARHAASLATAIAADLGLPPRTTACRAIARFAVDAHVLAREARDPEAAVDEVFRMIQAAWDAADLHADAPQDR
>CP029607.1|AXX30568.1|3786118_3786340_+|hypothetical-protein
MARRVAKPLARGVVRTSAGIVAGARRAAHAVGEELQDITAEVTAELAAARLTADVGAPAQGAPAGTGPDAGAR
>CP029607.1|AXX30569.1|3786383_3788636_+|ABC-transporter,-transmembrane-region
MTQLLDAAPTTRLTGFRVRSVVPGRQRWDVPRVRGNPRAARALEAALLRLPGITGAQASPSTGRVLVLHDRALGVAEVGAALRDAVTAAATAPLVVEGSTTTSSPATAASTPGGTSGGSVALRPVSAVLRRPLALVAVVTGVSSAVLRHAWRALLRPLRRTAAGARLSAHPLARVLGRHRSALAAAAALTVACQLAELGLGLFLGWILLVLIKGEYAPLTALGVTSAPSQLLALAAGAAATCGVVVVLSAAAGARWRALGQGVRRDQRARLHRHAQRLEMRHIQRERPTRVAGVLADDVDQLGAFFSGPAGEAVQLATSALILVPSFLVLAPGIAWIAFLPLPFVAVLSLRQRDRSAADYADAGEQAALLRSRISANLEAAATVKSACAEDHEAELVDLLELAGSDAATRTQQHTVRFGEGIRAWTTCSMAGTLLVGGLKVLDGSLPFERFSPLIGLPQQMVMRLTRLGPIVDQYQRTLAAHDRVEHLMSLPTETTGGRALARERVSGAIALDRVSFSYEGRPRVLDRLSLRAAAGKVTGIVGATGSGKTTVAKLLMRFQDADSGRVLLDGRDVRGLRLPDLRACVGFVSQDPFLFDGTIADNIRYGTFSATDEQVREAARTAEAHSFVESLPLGYDTVVGEHGASLSGGQRQRIALARTVLKNPPVVVLDEATSAVDNETEAAIQRALATFARGRTLIVIAHRLSTVRNADHIYVLERGGVVEQGAHEGLVASGGRYASLWELQAGARG
>CP029607.1|AXX30570.1|3788644_3789895_+|Na+/H+-antiporter
MAAPAGDSLVALLFLDLAVVLALGALLGALARRLGQPSVVGEVAAGIALGPSLLGLLPGDPVALLFPPEARPPLAFAAQLGLVLFMFLVGCELDVAELRGAGRVVGAVSAGSVVLPFCLGLGVAALLWPRGGDALALFTAAALSITAFPVLARILAERRMQRTRSGVVALASAAVNDVVAWCALAVVAGIVTARGPWSAVATLAWTAALVLVAVLLVRPLVGWAARAVGGSPRADAVLFAVVVQGLLLFALATTAIGLHAVFGAFLFGAVVPKDALREAAPTLVDRVGGLSSLLLPVFFVVAGLSVDVGGLGWSGAGEALLVLVAACVGKLVGAAGGGLLAGLPARDAAEVGVLMNARGLTELVVLGVGLELGVLDGHLFTVLVVMALVTTAATGPLLTLIARRSGREASALGGVR
>CP029607.1|AXX30571.1|3789993_3790569_-|hypothetical-protein
MNTTPKINRAGAARRTLVAAAGLALALAGPLAASGTAFADQAPEESRSTTVTIADAGTENCLTALDEHAAVLPCDGEANQEWELAEVDGNAVTLEAVAFEGRCLASEDVWYVALQDCEGGASETWALYDHGKESVSGLAEVTGDVAFVSPTQFPLTNQFGLAMVGTGKPAKALWTVTEVEETEESEDTVQG
>CP029607.1|AXX30572.1|3790813_3791860_-|O-methyltransferase,-family-2
MTLIDDERTAHRHDEGAAAFQALATAAAGWGALRAAVELGLPDLLPDAPTSVPDLAALAGAAPTRLAQLVAVLADVGVLALDERAHVRHTPLSRALRSTDGLPLTRLLTAGWADEAWRGLAEGVRADVSPLELVHGRPLFALLAADPAAAEVFHEAVATGPGDPFDEAIRSALDLTGAARVADVGGGRGRLLAALLREHPGLSGVLFDLPEAVRDAVPELRDDDRVEIRAGDLFADRVGAADVYVLRTVLHVLDDAQAVRALANVRADAPAHARVVVVEALSDDEAHRTYAAHSSLRLFVLCGGRERSTAEFAELFDRAGLELRSVTPTGTPYHLLEGAPRLSPRTDG
>CP029607.1|AXX30573.1|3792049_3795226_+|regulatory-protein,-LuxR
MRLVDRDGQCEALAALLEGAAGGCGGAVLLRGAPGHGKTALLGRLVALAEAAGFRCLVVEADALPEVAEVAAEVADGGGALLVAVDDAGGADVGALLDLAAWARRAPAVLALTDLPRLPDDDPLGAVARTPGALVLDLPPLRAETTAALLDGTPWPVTGGNPALVRGLARDLAAGEAGPGAAYRAALAGVLDRCGAEVAAVAHASAVLAVLPAGPAAALPGGLLPGAALPHGALPAAARPGVVCPDTALPGGALPDGGARPLASGAAGVRQGGVVPLAPGRTGASPGGAEPLLLGPASGVGGDPAGGDGTSASGRMAADHVVPGGARLRAPSGPAAPVDLVADLLGRAPASVADARARLVGAGLDRADPAAVLDVLPAARRAELHLRAARTLHERGESPAAVADHLVTAGLPAPAWAVDVLVAAADHALAADDVPTAVDRLAAAHRRDEADPPRGVHPRGVPDPAVAARRCGCADRTAAPADRRTSPEPTALSEPAAVVGPALTARLARARWQLNPAAALCHLDPLADALAADPAALAPRDAAALVRQLVWHGRTAAAGRVLAALRAREHAAELPDLETWLSLACPPLAASRRTAFSHTAFSHSAARHGSALHPNALHPNALHPGALHPNAPHTSASRTAAHQRGTPHPAALNPTTPPSSRVDPWLREAASLVGGFVLGDQRRAAAEAAHYLRHAQLSHTSPWSEEPALLALLALVRADRAVEADRACARLLDEARSRRAPTWVASFAAAASVIALRLGDLAGAAGHARAALDAVPAHGWGAGVGLPLGSLILADTLRGRRREAGRHVTAPVPDALFDGPAAPHYLHARGHHHLASGRDHAALADFLACGDLLRSWGLDLPGLAPWRTGAAEAWTRLGNHDRARRLVFDQLATTGADAGRPRALALRALAPLSPPTRRPHLLAEAADALERCGDRYELAATLACLGAAHHALGDHRRARAVLRRAWHLARACGARPLCARLEPDAADPVAHDTSGLTGSERKVAALAVTGLTNRQIAEKLFVTPSTVEQHLTRVFRKLRVTHRTDLPTTLHADLTTPA
>CP029607.1|AXX30574.1|3795436_3800230_+|Malonyl-CoA-acyl-carrier-protein-transacylase
MTDGTHEKLVDYLRWVTADLHETRRKLADLESAGHEPIAITGLACRAPGGVRTPEALWELVDGGVDAITGFPTDRGWDLAGLYDPDPTRPGTCYTREGGFLHDAAEFDAGFFGIGPREAVTIDPQHRMLLETSWEAVERAGIDPLSLRGTGTGVFSGVVYQNYGNRRRVAEEFEGHLAIGSSGSVASGRVAYALGLHGPALTVDTACSSSLVAIHLAAQSLRRGECAMALAGGATVMPLSDVFVEFARQRGLSPDGRCKAFSADADGTAWGEGVGVVLLERLSDARRAGRPVLAVVRGSAVNSDGASNGLTAPNGAAQQRVIEAALEDAGLRPSDVDLLEAHGTGTRLGDPIEAAALQATYGRARPGGRPLLLGSLKSNIGHAQGAAGVLGLVKVVQALRHGVAPRTLHADRLTPEVDWGSGALRVLTEPAPWPRGERSRRAAVSAFGMSGTNAHLVVEEGDAPTGPGERRPAGALPLLLSARGGAALRAAAADLVELPGEPVDVCWSLLTGRARLVDRAVVVAADRAGFTAGLQALAADQPSAAAVTGRADVSGRTVLVFPGQGGQWVGMGARLLDESPVFAAAVARCAAAVERLVDFRVVDVLRGGDLGRVDVVQPVSFVVMVALADLWRSFGVAPDVVVGHSQGEIAAACVAGALSLEDAARVVVLRSRAIAVGVGGARLEGGGMASIPLPRAEVEELITGTGVSVAAVNGPGSVVVSGDVDPLVARVEGARRLPVDYASHSPAVDVLRGRLLADLAPITPRPATVPMLSTVTGKWLDGAELDADYWFANLREPVRFADAVTELAGADCAVFVEVGAHPVLTAAIQDVLGERTAVVTGTLRRDDGGLDRFLRSAAALHVRGVPVDWAPVFDGLDAHRADLPTYPFQRAHHWLQEAEPAATPAGGDDPLWAAARDADGLCAELELTEPDQRAALRAVLPALTAWHERRSERALLDSWRYRITWRTLPEPPEADPRGDWLVVGPHPDLLPDLLPGVALDPDRAALADRAALADLLRPHAAVAGVLATPGADVLALVQALGDAGVTAPLWCATTGAVAISPHDGPPDPAQAATWGLGRVVALEHPGRWGGLVDLADPADPRQRRRLAAVLAGPGVDDGGEDQVAIRAEGVFARRLVRAEPQAPAAPWTPRGTVLVTGGTGGVAAHVARRLAALGADHLVLTSRRGPSAPGAPALAADLEALGSRVTTAACDVADRAALAALLADLERAGDQITAVVHAAGANAQTPVADTTPEELARVQAAKALGAEHLDELLGGRPLDAFVLFSSNAGVWGSGGQCAYAAANARLDALAQRRRAHGRVATSVAWGAWDGGGMSSATPDIAAQLAQAGLRLMPPDLAVSALLDAVARDETTTVVTDVRWEAFAARFTALRRSPLLADLPEARPEPVAAADEPDRGLAGELAALPAPERLRRLTDLVRAHAAAALGHPGPESVPADVAFRDLGVDSLAAVELRNRASAATGARLTPTAVFDHPTPRALAAHLAEHLAATKDSGAPDAAPDIQDPTAALRGLDALAAALPAAAGDDALRERVTARLREVLGRWDELTGDPGGPDGFDLDHISDDELFRLADSRLGPTGA
>CP029607.1|AXX30575.1|3800239_3810259_+|Malonyl-CoA-acyl-carrier-protein-transacylase
MSDEKKLRDYLKRALAENERVQQRLRALEAANREPIAVVATACRFPGGVASPEDLWDLVARGGDVISGFPTDRGWDLDALFDGDPEAQGRSYVREGGFLREATEFDAAFFGISPREALAMDPQQRVLLETAWEVVERAGIDPTSLRGSRTGVFTGVVYYDFATRLHPVPEGMEGHLGTGIAPSVISGRVAYVLGLHGPAVTLDTGCSSSLVGLHLAAQALRSGECSLALAGGVTVMSLPGAFPEFSRQRGLAPDGRCKSFADAADGTAWSEGVGLVLLERLSDAERAGHPVLAVLRGSAVNSDGASNGLTAPNGVAQQRVIRSALEFAGLRPSDVDLVEAHGTGTRLGDPIEAQAILATYGQDRAEPVLLGSVKSNLGHTQGAAGAAGLIKVVEALRRGEVPRTLHVDRPSAQVDWSAGNAALATEHVPWPDRGRPRRAAVSAFGVSGTNAHVVLEGVPAPEVPPRDDRALPLPLSARAEPALRALAGRVGALLDGPVALADVAGSLADGRARLAHRAVVVAEDRAGARTALDALAAGEPHPDLVTGVADVDGRTAFVFPGQGAAWVGMGARLLTESAVFADSVDRCAAALAPHTDVDLRAALTGGPLDRVETVQVAAFAVAVSLAELWRAHGVEPDAVLGHSQGEIAAACVAGALTLEDAALVVALRSRAVAEHLSGRGAMLSVALPPHEVGSFGLAVAAVNGPESVVLSGPVADVEAALAALTASGVRARRVPVDYASHSPGVEVLREVLATALAPVRPRRARVPFLSSTTGAWLEGPELDAGYWFANLRGAVGFHAATTTLLDAGHRAFVEVSAHPVLTGAVQDSADGRAVVTGTLRRDQGGLHRFRLSAAELHARGVPVDWNAGSGDRWRRVDLPTTPFHRQRCWPDARRAATDQPGLRAANHPLLDTVVALAGGDGVVCAGSASTRAHPWLADHAVSGTALLPGTGWVELAVRAGDEVGLPVLDELVVEQPLPLGPQTTPLQVRVGPLDATGRRPVELHSGSASGGEWTRHARGHLTAATPTTAGGPVEWPPPGAREVDLTGFYERQAATGYGYGPAFRGLRRCWTRDGEVFAEVVLPGEPGAFGVHPALLDAALHAAAVTAPEGVPVLLPFTWTGVALHATGARALRVRLTTPRAGELALTASDGDGRPVVTVESLVLRPAGDLTATRTPRSLFEVVWTEAPAQAPTPTPTSPRPVLRHDVPAASAEDAVCSVLAVVQGFLADPRHADSVLLVVTRGGEGPDGATAATSAVHGLVRSAQAEEPGRIVLVDTDGSAPDDLITALAAGPEPQLAVRAGRVTAPRLRRAAPAGAVPAAPALAPEGTVLVTGGTGVLGAAVARHLVTAHGARHLLLLSRRGPDAPGAADLVAELTGAGAHVVVRAVDVADRAALAAALDAVPAAHPLTGVVHLAAALDDGTITALTPERVRRVLAPKATAAAHLHELTSDLALFALFSSASGVLGAPGQGNYAAANAYLDGLARERHAAGLPATSIAWGLWAEATGLTGSLSGTDRERMAASGVRPLTEAEGLALFDAALAGPAFVAAGLAGSATGQVPPVLRDVVRATRPAAAAVRPARTPADLLALVRAEAASVLGHPAGEPVDADRAFKEAGFDSLTAVELRNRLTAATGVRLPATLVFDHPTPAALADHLVERMGAPVAPRPERAAKAASGEPIAIVSIGCRLPGGVTSPEGLWRLLLDGVDATTGPPDDRGWDPATPYRGGFLDGATTFDAGFFGIGPREALAMDPQQRLLLETSWELFERAGIDPTSLRGTDTGVFAGVMNQDYLSRAAGAPPDAEGFLSTGNSGSVVSGRLAYTYGLEGPALTVDTACSSSLVAVHLAVRSLRSGECSLALAGGVTVMATTGLFADFDRQGGLAADGRCKAFSADADGTAFGEGAGLVLLERLSDARRNGHAVLAVLRGTAVNSDGASNGLTAPNGPAQQRVIRAALADAGLSPAEVDAVEAHGTGTRLGDPIEAQALLATYGQGRGEPVLLGSVKSNLGHTQGAAGVTGLIKLVLALRHGVVPATLHAGRASAEVDWDAGAAELATGARPWPRTGRPRRAAVSSFGISGTNAHAVLEQAPEDVDGGVVEVAPAGVPRDGRARAADLATAGARGSEADGAASPVGAAAGSGVTGARESEVEPGGVDPAAASTDAAQAAAAQSGGTAAREPETGVAADPGGPGSTVVPADAARAADVAGADPAPLAPLVVSARDERALAAQVERITALPHDPVDVGWSLVTTRATLRHRAVLLDGEVVASGVPAPGGTAWLFTGQGGYRPGTGRALRARFPAFRDAFDATCAELDRALDGRAGHPVRDVALGERPGLDGTLHAQAAAFALQTALAAQLGAFGLAPDAVAGHSVGEIAAAHVAGAFPLDAACALVAERGVLMRDLRPGAMVAVEVTEEEALDAIGDLPVAVAAVNGPEAVVLSGDAEAVVAVAARLGGRRKRLPVDRAFHSPHVDPVLDALRGLATGVPTTPLISTTTGGPLTRVGDDHWADHARGAVRFADALRALVDSGVTTAVELGPDAVLTPHAAEVLARATPTLRADHDEVASLLTALAVLHARGAAVDWRPAFEGAGARRVDLPTYPFQRTRYWLDAAPRATATGHPLVDALDVLPGDEVLLSARWHAGRAGLGATPLAALLEPVIRAGDEVGCPVVAELHLATPVPLDAGPRHVRVRVAAPDADGRRAVTVHSRPDDEPAWTGHATGVLAPAGHPEPQSHEAGALGAGADGHGAGAPVGGTNGAWLPHDSGALAAGANGARSTPDATGPALGAELVLPDGAEPDGFGLHPALWEALLPHPARCADVVLHATGATALRVRGTSPLLAVDGAGDPVVSVGGVTRAVASPRAVTRGSLFEVVEVPLPTPAPTGPSTALSADLRGATPAEALDVLQRFAAGDAPRLVVRTDRPDDPWQCAVRGLVRSAQAEEPGRILLLVQDGDGPEPPPTTREPEVVVRDGALRVPRLRRTAPRHDGVRALPDTVLITGGTGALGSTLARHLAAGGVRTLVLASRRGPTAPGAPELAADLARLGARAHLVAADLTDRAALAALLAEHRPGGVVHTAGVLDDGVLSALTPARLDAVLAPKALVAAHLDELTRDPATTLFVLFSSAAGVLGTPGQANYAAANAFLDGLALRRRAAGLHALSLAWGPWRSGMAAGVDASRAGLHPLDDAEATALFDAALADGRTLLAPLSLAATPQDVDVLPLLRQLVPVRRRSARAEVAGDPVDRVRDAADHELPELLLALVRTATATVLGHRGPESVDPDEPFWDTGFTSLTAVELRNLLTERTGVRVTAAAVYEEPTPRALSAHLRAALRAPHPSGTV

Crispr_ID: CP029607_3

• CRISPR_ID: CP029607_3
• CRISPR_location: 3827722-3827811
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP029607_3

Consensus_repeat	Method
GTCCGGGCCGACGATCCCGCGTGGGG	CRISPRCasFinder

spacers of CP029607_3

>3.1|3827748|38|CP029607|CRISPRCasFinder
CCGTCGCCCGTCGTGGGTGGCCCGATGGGCTGGGGGGT

CRISPR arrays and Neighbor proteins around CP029607_3

CRISPR arrays

The CRISPR arrays of CP029607_3

>merge|CP029607|3|3827722-3827811|CRISPRCasFinder
GTCCGGGCCGACGATCCCGCGTGGGGCCGTCGCCCGTCGTGGGTGGCCCGATGGGCTGGGGGGTGTCCGGGCCGACGATCCCGCGTGGGG

>CP029607|3|3|3827722-3827811|CRISPRCasFinder
GTCCGGGCCGACGATCCCGCGTGGGG	CCGTCGCCCGTCGTGGGTGGCCCGATGGGCTGGGGGGT
GTCCGGGCCGACGATCCCGCGTGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP029607.1|AXX30584.1|3819784_3822493_+|transcriptional-regulator,-SARP-family	unknown	unknown	gnl|CDD|276938
CP029607.1|AXX30599.1|3857116_3857692_+|cytochrome-P450	unknown	unknown	gnl|CDD|365848
CP029607.1|AXX30585.1|3822518_3823655_+|Acyltransferase-mdmB	unknown	unknown	gnl|CDD|224748
CP029607.1|AXX30582.1|3817608_3818901_+|FkbH	unknown	unknown	gnl|CDD|273757
CP029607.1|AXX30590.1|3827987_3828422_-|3-dehydroquinate-dehydratase-II	unknown	unknown	gnl|CDD|235443
CP029607.1|AXX30595.1|3853226_3854435_+|putative-glycosyltransferase	unknown	unknown	gnl|CDD|340817
CP029607.1|AXX30591.1|3828642_3829809_+|Lipopolysaccharide-biosynthesis-protein-RffA	unknown	unknown	gnl|CDD|366433
CP029607.1|AXX30598.1|3856453_3857074_-|Transcriptional-regulator,-TetR-family	unknown	unknown	gnl|CDD|224228
CP029607.1|AXX30596.1|3854702_3855728_+|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl|CDD|187618
CP029607.1|AXX30580.1|3815152_3816148_+|3-hydroxybutyryl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|224170
CP029607.1|AXX30589.1|3827396_3827582_+|Mobile-element-protein	unknown	unknown	gnl|CDD|290319
CP029607.1|AXX30588.1|3826654_3827020_+|hypothetical-protein	unknown	unknown	gnl|CDD|371368
CP029607.1|AXX30593.1|3843721_3853150_+|Malonyl-CoA-acyl-carrier-protein-transacylase	unknown	unknown	gnl|CDD|225858
CP029607.1|AXX30587.1|3824234_3826259_+|Nodulation-protein-nolO	unknown	unknown	gnl|CDD|225103
CP029607.1|AXX30592.1|3829997_3843725_+|Malonyl-CoA-acyl-carrier-protein-transacylase	unknown	unknown	gnl|CDD|225858
CP029607.1|AXX30583.1|3818893_3819556_+|O-methyltransferase,-family-3	unknown	unknown	gnl|CDD|366722
CP029607.1|AXX30586.1|3823669_3824017_-|hypothetical-protein	unknown	unknown	gnl|CDD|226318
CP029607.1|AXX30581.1|3816144_3816417_+|Acyl-carrier-protein	unknown	unknown	gnl|CDD|223314
CP029607.1|AXX30597.1|3855807_3856272_-|hypothetical-protein	unknown	unknown	gnl|CDD|379556
CP029607.1|AXX30594.1|3853112_3853271_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP029607.1|AXX30584.1|3819784_3822493_+|transcriptional-regulator,-SARP-family	gnl|CDD|276938	cd15831, BTAD, Bacterial Transcriptional Activation (BTA) domain. The Bacterial Transcriptional Activation (BTA) domain is present in the putative transcriptional regulator Mycobacterium EmbR and the related Streptomyces antibiotic regulatory protein (SARP) family of transcription factors, which includes DnrI and AfsR, among others. Members of this family contain an N-terminal DNA-binding domain, followed by the BTA domain, and many have diverse domains at the C-terminus. EmbR contains an C-terminal forkhead-associated (FHA) domain, which mediates binding to threonine-phosphorylated sites in a sequence-specific manner. The BTA domain of EmbR contains three Tetratricopeptide repeats (TPRs) and two C-terminal helices. The TPR motif typically contains 34 amino acids, and 5 or 6 tandem repeats of the motif generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein.	1.43618e-48
CP029607.1|AXX30599.1|3857116_3857692_+|cytochrome-P450	gnl|CDD|365848	pfam00067, p450, Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyze regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.	1.41835e-15
CP029607.1|AXX30585.1|3822518_3823655_+|Acyltransferase-mdmB	gnl|CDD|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	3.89211e-26
CP029607.1|AXX30582.1|3817608_3818901_+|FkbH	gnl|CDD|273757	TIGR01686, modular_polyketide_synthase, FkbH-like domain. This model describes a domain of a family of proteins of unknown overall function. One of these, however, is a modular polyketide synthase 4800 amino acids in length from Streptomyces avermilitis in which this domain is the C-terminal segment. By contrast, the FkbH protein from Streptomyces hygroscopicus aparently contains only this domain. The remaining members of the family all contain an additional N-terminal domain of between 200 and 275 amino acids which show less than 20% identity to one another. It seems likely then that these proteins are involved in disparate functions, probably the biosynthesis of different natural products. For instance, the FkbH gene is found in a gene cluster believed to be responsible for the biosynthesis of unususal "PKS extender units" in the ascomycin pathway. This domain is composed of two parts, the first of which is a member of subfamily IIIC (TIGR01681) of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. All of the characterized enzymes within subfamily III are phosphatases, and all of the active site residues characteristic of HAD-superfamily phosphatases are present in this domain. The C-terminal portion of this domain is unique to this family (by BLAST).	1.49829e-99
CP029607.1|AXX30590.1|3827987_3828422_-|3-dehydroquinate-dehydratase-II	gnl|CDD|235443	PRK05395, PRK05395, type II 3-dehydroquinate dehydratase.	3.09321e-73
CP029607.1|AXX30595.1|3853226_3854435_+|putative-glycosyltransferase	gnl|CDD|340817	cd03784, GT1_Gtf-like, UDP-glycosyltransferases and similar proteins. This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the oxidatively cross-linked heptapeptide core of vancomycin group antibiotics. The core structure is important for the bioactivity of the antibiotics.	1.94773e-41
CP029607.1|AXX30591.1|3828642_3829809_+|Lipopolysaccharide-biosynthesis-protein-RffA	gnl|CDD|366433	pfam01041, DegT_DnrJ_EryC1, DegT/DnrJ/EryC1/StrS aminotransferase family. The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.	1.10212e-133
CP029607.1|AXX30598.1|3856453_3857074_-|Transcriptional-regulator,-TetR-family	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	9.9372e-08
CP029607.1|AXX30596.1|3854702_3855728_+|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl|CDD|187618	cd05360, SDR_c3, classical (c) SDR, subgroup 3. These proteins are members of the classical SDR family, with a canonical active site triad (and also active site Asn) and a typical Gly-rich NAD-binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.45835e-110
CP029607.1|AXX30580.1|3815152_3816148_+|3-hydroxybutyryl-CoA-dehydrogenase	gnl|CDD|224170	COG1250, FadB, 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism].	3.1571e-81
CP029607.1|AXX30589.1|3827396_3827582_+|Mobile-element-protein	gnl|CDD|290319	pfam13586, DDE_Tnp_1_2, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	0.000150479
CP029607.1|AXX30588.1|3826654_3827020_+|hypothetical-protein	gnl|CDD|371368	pfam11080, GhoS, Endoribonuclease GhoS. GhoS is part of the GhoT-GhoS type V toxin-antitoxin (TA) system. GhoT is inhibited by antitoxin GhoS, which specifically cleaves its mRNA.	0.00513612
CP029607.1|AXX30593.1|3843721_3853150_+|Malonyl-CoA-acyl-carrier-protein-transacylase	gnl|CDD|225858	COG3321, COG3321, Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	0
CP029607.1|AXX30587.1|3824234_3826259_+|Nodulation-protein-nolO	gnl|CDD|225103	COG2192, COG2192, Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones].	3.32341e-164
CP029607.1|AXX30592.1|3829997_3843725_+|Malonyl-CoA-acyl-carrier-protein-transacylase	gnl|CDD|225858	COG3321, COG3321, Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	0
CP029607.1|AXX30583.1|3818893_3819556_+|O-methyltransferase,-family-3	gnl|CDD|366722	pfam01596, Methyltransf_3, O-methyltransferase. Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.	6.35669e-66
CP029607.1|AXX30586.1|3823669_3824017_-|hypothetical-protein	gnl|CDD|226318	COG3795, COG3795, Uncharacterized protein conserved in bacteria [Function unknown].	4.24026e-15
CP029607.1|AXX30581.1|3816144_3816417_+|Acyl-carrier-protein	gnl|CDD|223314	COG0236, AcpP, Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	4.00217e-07
CP029607.1|AXX30597.1|3855807_3856272_-|hypothetical-protein	gnl|CDD|379556	pfam14325, DUF4383, Domain of unknown function (DUF4383). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length.	1.78806e-41

Protein sequences

>CP029607.1|AXX30589.1|3827396_3827582_+|Mobile-element-protein
MPRGGPGRPRTRPDHVVADKGYVVECCFNRLEQWRGLATRYGKTRESYQAVVAIASILLWI
>CP029607.1|AXX30588.1|3826654_3827020_+|hypothetical-protein
MAAGALESVLAKAEVERLVARLALVGGGRDPLVAAATSCLTAVVLLCEAWEQRGAEDGCDVPEGQGAESCREALGATRAAVEATRFALVEANDRARRAAAEPAASRRAGGLRVPGVRTAAD
>CP029607.1|AXX30587.1|3824234_3826259_+|Nodulation-protein-nolO
MTETMLVLGLNGNFSTAAEELVPGMLEFFFHDSSASLARDGELLAAVEEERYNRIKKTTRFPSAAVRACFEETGLGPEDVDAVAFYFPEDHVDKVLGQLYCQSPAVPLRYSRDLVRDRLRSELGWDLPPEKLHYVPHHLAHAMSSFGHSGFESALTVVFDGRGENASGTVYRIGPGGVESLASYPVHQSLGFWYLFGTQLLGYGFGDEYKVMGLAPYGDPARYRSVFESLCSLGEGGGYELLGNVVTPNAFLPAMLDTGFAPRRKGEEFTRDHKDFAAALQETVERIALHVIRHWAERTGERALCFGGGVAHNSSLNGVILRSGLFDRVFVHPASHDAGAGTGAALAVEHRLTGRLPRVALRRADLGGGLGDERDVVLKLKGWDGFVELVHRAADLEDLVDTSARLLADGAVLGWARGRSEFGPRALGSRSIVADPRPAANQTRINAMVKKRESYRPFAPVVTPDAAAEYFEIPDVEAELGFMSFVVPVRPEHRAGLGAVTHVDGTARVQVVTSTANPAFHRLVERFGELTGTPVLLNTSFNNHAEPIVQTFEDVLTSFLTTELDYLVVGDSVVRRRPDFLGALDDAVIRFRPETRVVGRVRFPVGGGRVEEHEVFLDYAEGPRKTISARAHGLLTRVDGKSAVAELVDGEVDDALRQEVLDLWTDRYFTLGPA
>CP029607.1|AXX30586.1|3823669_3824017_-|hypothetical-protein
MKYMLLIHTSDERWQTLSQADKEEFLAEYAAFTEEIESTGEHCHGSPLTHRRNAASVRVRDGRAAVERGPLTDNDRYLAGYFVVDCADEDRALEIAARVPDAKLNVVEVRALAVV
>CP029607.1|AXX30585.1|3822518_3823655_+|Acyltransferase-mdmB
MTPGPVLPPRLPSLTGVRAPLAVLVFVAHALGSARFFADDSINSLGFLLPYGPAALSLFFVLSGFVLVWSEPWREGVGPYFRRRVVRILPTHALTWAAVLLLLAALGPLPLLGPLPEVGPALVNLSLLQSLVPLPDYLLSVNGINWSVSCEVVFYLLLPVISRPLLRVPDHRLWACFGALAAVVLVLPGVIGALVDGPPWALWPPLSFEQAWLVNFFPLTRLPEFLMGVVLARIVATGQWRPVRAWWPLLGVAAVWALLPVLPQVYARSAIAAVPLALLVPVMAVRDLEGRRSWLSRRWVRVAGDMSYATYLLHWPLLAVAKHVMGDRLVGWGEGLLLVAALYALTQGLSLLLHRWVERPLLRRVHRPRLSPAPDPAG
>CP029607.1|AXX30584.1|3819784_3822493_+|transcriptional-regulator,-SARP-family
MALGGTKQRAALGYLLLHPNSVVPTSSLLKALWPKDMPPTGRKMLQNAVAALRGVLTAAGDSPGAPALLTHTPGYLLRVDPEDVDLSRFRRLVHAGRADLTAGSWQRAARTLRDAIGLWRGPLLADLVEQGVDWPELAAVRNTRLAALEDCVEAEFASGRYGEMIYELERWVEAEPLRERLCGQLMRALYHCGRQADALGVYRRTRARLVDELGLDPGRELRELERAILNQEVPHRLPARRETAPAARSGAAEGGGPVAAPPVAALPVGIVPQRQAPPAPAPVTPAPVALAPLPPASAPTAELKHVSVLMVLTRFEHDVAAAPPEEVDDALSDVAAAVREEVERAGGVVTAKAASLIVALFGSTRSGEDDATRAVRAALAVRDRLAHGPRGAGPAALGVTAAVATGHALVRRHPGRAPEVGGGVLDRCMRLLAHVSPGEVRVCEETRGASEGAIGYDGPHDPVRGSWATGARQGAGGTPAAPPLVDRDRELALLRGLLEQVGRRSRTHLVTVLGEPGIGKSRLVDEFQRVAETSSTVVVRCPRLGGGGDLAPLADALAPRMGIGPADPVGLVAAKLAAAARGSGGAGERADRLLARLRVLFGLDVPDVLPDGSFAAWRHVLEDLGGADPLVLVLEDLHWAGEALLDFVDHLTAEATSSPLLVVVTARPELFDRRPAWGGGKAEASTITLDPLADQDVERLLTALCVRRGPASAPTDEARAAYREVIAHIGGNPLFAVEYARVLADAGPPSGGGGQSPPLPPLVRRVVAARIDSLPADAKAVLLDAAVLGEDLCEEGVRALGGGAVPDVARALEHLERREVLRRDRDAERATAYAFRSPLVRDVAYLTIPQHARAEKHRRAADWLERVPGHDALRLVHHGLRSGGCRPVEPSPVLPQPRQHAR
>CP029607.1|AXX30583.1|3818893_3819556_+|O-methyltransferase,-family-3
MGEQVVVTPALLDYVREVSQPEPAVLAELRAETALLPGGGVLPVPPGEGAFLALLVALTGARLVVEVGTFTGYSTLCLASALPDGGRVITCELSPKWPAIARPHWERAGVADRIEVLVGDAADSLAGLTGELAGRVDLVFVDADKAGYPRYYELAVELVRPGGLVVVDNTLFSGRVADPAAVDPDTEGVRELNRRIAADDRVQAVLLAHADGMTLARRTR
>CP029607.1|AXX30582.1|3817608_3818901_+|FkbH
MTGDGAGGGVNGGDLVKCLVWDLDDTLWRGTLAEGDAPVLDERVRAAIVELDARGVLQSVASRNDPEPALAALEALGVAEYFVLPEIGWGVKSAAVARIADRLGFAHRAIAFVDDRPAERAEVAFHLPEVRCYPAERVLELCSLPEFSPAVVTEDARNRRALYRAGFARGAEQAAFTGPDEEFLRSLGLVLRIDRARPEDLHRVEELTARTSQMNATGVHYPHGELRALLDDPAHEVLVAGLTDRFGPHGAIGIVLLERHAAAWHLKLLATSCRVVPYGVGSVLLDWLCGQALEAGAHLVADFRRTDRNRMMEIAYRFAGYDDADCACRAELAAVSGGPEHLAAAGSPGAGAPVGGASVGGAPGTGVPGTGAPETRVAESRAADVPVTQVPEARAVGTPVRRLHLLPAPRPAPRAVTVEAPSLLEVPTRG
>CP029607.1|AXX30581.1|3816144_3816417_+|Acyl-carrier-protein
MTSGTESRTDDVQGVVLDFLRARTGAEWDAERDLFAEGGLSSLFAMELVVHLEQCFDVEIAGPDLRLDNFRTVRAMTALVDRLRAGGAGG
>CP029607.1|AXX30580.1|3815152_3816148_+|3-hydroxybutyryl-CoA-dehydrogenase
MPGDTDDPPTRALASPSSDNPSSDNPSPDGASPDGAARGEPGRPAGERPLLVLGAGVMGCGITALALSRGLPVLLVDPDADRLDAARADVRAHLRTAQLLGVATGPLGELSTATDPSGAHEVVAVVEAVTEDAETKAKALTGVCATVPPGTPLVSNTSSIPMGELAPALPRPGDLVGAHFMNPPYLIPAVEVARGPLTSDAAFTGLTALLARLGRAPVQVGDAPGFVTSRLLHPMINDAARVVESGTADAAAVDALMRDCLGHREGPLRTADLIGIDNLVDSLRVLRLRTGDERCEPCDLLLAKVGAGHLGRKSGRGFYDYGHPGREGTGR
>CP029607.1|AXX30590.1|3827987_3828422_-|3-dehydroquinate-dehydratase-II
MPDLLLLNGPNLGILGRREPEVYGTATLADIEDAVADEVADRGWKVVARQHDGEAEMIGTIQDSYDTVGAIVNPGALMIAGWSLRDALANYPSPWMEVHLSNVWAREPFRHQSVIAPLATGLIAGVGALGYRLAARALLDRVAD
>CP029607.1|AXX30591.1|3828642_3829809_+|Lipopolysaccharide-biosynthesis-protein-RffA
MHLKAPQKLEFPAWPQFDSTEREALLRTLDSGRWWRITGDEVVSFEREFAQAHGARHALAVTTGTHALELVLEVMGAGPGAEVIVPAFTFISSSQAAQRLGAVVVPVDVDPDTYCVDPAAVRAAITERTRAIMPVHMAGQLADMDALRALSAETGVPLLQDAAHAHGARWRGEPLGALGSIAAFSFQNGKLMTAGEGGAVLLPDGDQHEEAFLRHACGRPLADRAYHHRTAGSNFRMNEFSAALLRAQLGRLQQQTDVRERHWPVLARLLAEAPGVVPQGTDPRCDRNPHYMAMFQVPGIGEERRARLVDALVERGVPAFAGFRAIYRTAAFWERSAPDTTVDALARACPVTEALSSDCVWLHHRVLLGTEEQMPLVAEAVADALEEV
>CP029607.1|AXX30592.1|3829997_3843725_+|Malonyl-CoA-acyl-carrier-protein-transacylase
MLRSDLIRPLPELLREHAARRGDRVAFRDARRAVTWADLELRTRRLAGHLAARRLLPGDRAVILLGNRVETVECYLALVRAGAVGVPLNPVSTDAELGGLLDDSGARLVLTDAAHADQLAGLRATRPALEVVHVDRDYEALAGVDAPLPAHDALELDDLAWMLYTSGTTGTPKGVLSTQRNCLWSVAACYAPVLGLTPDDRVLWPLPLFHSLSHIAGVLATTAVGATTRVVDGRSPQDVLAALHEERSTVLAGVPTTYHHLVRAAGERGFLAPDLRVGLVGGAITTAELRAAVEQRFGVPLIDAYGSTETCGSITVNWPTGPRVEGSSGLPVPGLAVRLVDPDTGLDAPTGAEGEVWVRGPSVMLGYHNRPEATAAALRDGWYRTGDLATRDESGFHAVTGRIDDVVVRGGEKVHPAEVEAVLRAVPGVADAAVVGRPHDVLGEVPVAFLVPGEGFDPARVLAVCRERLSYHKVPEELYQIESVPRTASGKITRRVLLDTPARLRARGERGALFRTDWVPLTAAVGAVTAPGSAVTEPGAETTVGAATDPDAGSPAGAPTAPVPAPGDAPVVLDLRGDDAPALSGRPDLVLTRGAVAVDGGPVRLGQLAAWTAARRAGITAVDTDDDAAVDPVALLAAGEPRLLVRSGVVLVPRLHEVPGSVVGRGALDPRRAVAVTGADSGTAAALARHLRGAHGVRDLLLITGPDGRARAGALRDDLVASGARVVLAVAGPDALDRALSRAPSPLGALVHTGDGDQEALPYLLGARVELVVCATAFDSAAAEDVVLRRRAAGMPARCLAWGPWEAEAAQARPGLAVLPLRDGLAAFDAALGADEPVVSVLRPDPDLVAGDVPAPLRDLLHVVAAEPEPVRVAELRAGLAGRGERERRRRLLDLVRAETAALRPAEFVVDGHERGFAELGFTSATSVALRNRLTAATGLALPATAAFEHPTPTALAGLLHDELFGASQSPEQAPVAPARAVERSGEPIAVVAAGCRLPGGVASPEDLWEVVRSGSDVVSPFPVDRGWDLDALRGACAGGGFLADAALFDAALFGVHPREALAMDPQQRLLLEVAWEVFERAGIDPRSVAGDGTGVFAGLMGHDYGSRPGLDRQLVEGYLSTGNAGSVASGRIAYAFGLTGPALTVDTACSSSLVAVHLAVQSLRRGECAMALAGGATVMATPADFVEFARQGALAPDGRCKPFSASADGTAWSEGAGLVLLERLSDAQRNGRRVLAVVRGSAVNSDGASNGLTAPSGAAQQRVIRAALADAGLSTADVDAVEAHGTGTRLGDPIEARALVATYGRDRGGEPLWLGSLKSNFGHPQGAAGIAGLIKLVQALRHGVLPRTLHVDAPTPEVEWNGVAVLAEQRAWPEVGRPRRAAVSSFGVSGTNAHVVLEQAPAAPAAPAAPERGAVPLPVSAVDAAALRAQARRLADFLAPSDVTAAELAGALRAGRADLGERAVVVADDRAGALAALEALASDEPSPALVTGRADVTGRVVLVFPGQGGQWVGMGARLLDESPVFAELVDECAAAVDPLVDFRVVDVLRGGDLSRVDVVQPVAFVVMVALARLWRSVGVEPDAVLGHSQGEIAAACVAGALSPADAARVVVLRSRAIAAGLDGGGMASIPLPQAEVEELVAGTGVCVAAVNGPGSVVVSGDVDALVARVEGARRLPVGYASHSPAVDVLREGLLADLAPITPRPAEIPMLSTVTGTWLDGPELDADYWFANLRHPVRFADAAALLVADGFRAFVEVGAHPVLTAPVQDLLAGAGPSVATGTLRRDDGGLDRFLRSAAELHVRGVAVDLSPLAPPPVRALDLPTYPFQRARYWLDADPTAASALRHPLLTSATDLAGGEDLVCQARLSTARHPWLADHVVRGSAVLPGTCWAELAIRAGDEVGAPALDELLVEAPLVLPERGAVEVQLRIGAPDAAGRRPLEAHARAEGGAWTRHASGSLAVDRSTPVPLTEWPPTGAREVDLAGFYDSRAAEGYGYGPALRGLRRAWTRDGEVFAEVELPEPLSPDGWGLHPALFDAALHATGLLPPTRVAADEVLLPFSWRGTRLRATGATALRVRLTGTADDHVLRAYDPEGTPVVEVDALRLRPAPATALVGSGALFRVEWVDLDVPRPTPGSESTTPVLDLPDGDARALLGLTLEALREHDELTVVTRGAAEDPAAAAVWGLLRTAQTERPGRFTLVDLDDDPASRALLPALPATGEPQVRVRAGRAGAPRLARTRDDGLRLPAAPTWCLTCDGGTFTDLAATPSPAATRPLEPGEVRVGVRAAGVNFRDAAVVLNAVPGQRGLGGEAAGVVLETGPGVTGLAVGDRVLGTFDRDFGAFGPVAITDARLLAPVPPGWGFARAASVPVAFLTALHGLRDLAQVGPGDRVLVHAGAGGVGGAAVRLAALLGAEVFATASPAKWPVLRALGLDDAHLASSRDTGFAERFPAVDVVLNSLTGELVDASLRLLAPGGRFLELGKVDVRDLVRADVAYRAYDLRDAGPDRTAELLAEVLGLFEQGRLEPLPLTVRDIRHAPEALRHVASGGHVGKVVLTVPRPLDPEGTVLVHGGGALGALTARHLVSAHGARHLLITSRRGPDAPGAAELAADLAELGATTRFERCDAADRDRVAALLADLGEHPLTAVVHTAGALDDALLADQDAARVDAVLRPKLDGALLLDELTRDADLAAFVLFSSAAGTLGNAGQANYAAANAALDALATRRRSAGLPATSIAWGHWESASALTAGLTAADLARGARHGAGSLGTTEALALLDAALASPEPAVLAAALDPRRAAEVPPLLRDLAGPRRAVAAQAVAGADRPLIDVVRAHTATVLGHRDASAVDAHRAFKELGVDSLTAVELRNRLAAATGLALAATSVFDHPTPALLTAHLLAELGHAPAAGTTAPATAVTADAGEPIAIVSMACRFPGDVSSPEDLWDLVAGGGDALTPFPADRGWDLATLLAPDPDGAGRSHARAGGFLADVAGFDADLFGISPREAIGTDPQQRLLLEVAWELFERAGIAPDSLRGTDTGVFAGVIAHGYPVLPAHSDQGLEGHRVTGASGSVVSGRVAYAFGLQGPAMTVDTACSSSLVGVHLAVRALRGGECSLALAGGVTVLSTPDLFVDFSRQRGLAADGRCKAFGAGADGTGFGEGVGLVLLERLSDARRNGHRVLGLVRGSAVNSDGASNGLTAPSGPAQERVIGRALADAGLSAVDVDLVEAHGTGTRLGDPIEARALVATYGRDRGGEPLWLGSVKSNIGHTQAAAGVAGLIKAVQALRHGVLPATLHADEPTPEVEWDGVAVLAERRDWPEVGRPRRAAVSSFGVSGTNAHVVLEQAPEERVPEGRGPERETPAGADDRDVPGHLPLVLSAHDPVALRATAAALLPVAEHLPLPDLALSLVTGRAALPCRAVLPARDRDQALAALRDLASGATEPAGRDGGSVAFLLSGQGSQRAGTGRLLERRFPVFRDALREVCALLDRRIVGGPGVRAALDDPGLLADTRYAQAGLFAVQVALVRLLDALGVRPDLLAGHSVGEIVVAHAAGVLSLEDASTLVAARGALMRELPPGVMVAVRAGEDEVRAALVDGVELAAVNGPRATVLTGDEAAVTEVAARLGRATRLRVAHAFHSAAVDAVLPAFADVLARLDFRPPRVPVVATAPGALDAPEYWLGQAREPVRFADAVTDLHRRGATAFVEVGPGGGLAAAAQECLDGHDVLCAPLLHRDRDEDHSLITALGALHARGARVDFAPLLADAGGRTTDLPTYPFQRRRFWLDPAPPTTDAAPLEHPLLTGELEIPGSDTAAFTGRAATGVHPWLADHRLLDAVVVPGTALLDLVRAAGRQLGLPEVAELVNEVPLVLGDGAALLRVTAAAPGPDGRREVAVHSRPESAGPRSPWTRHVTGQLAPDGGPLAFDLAQWPPPGAQPLPVADHRAAMAATGHGYGPAFLGLRAAWRLDDEVLVEAVLPDEVADDGHTVHPALLDAVLQALSLTGVEDGSQVRVPFSWRSARGAGRAGRAVRASLRPDGDGGVRVRVACPQGRPLLEIASLVSRPVTPDRLRPGVLLRQAWTEVGPPPGAAEPVPLREVGERVPPVVRVDAGHVRDLLPLLQEAVTEPRWESTRLLVTTSGAVGPRAGRAEGAAVWGLVRSAAAEHPGRFVLADLDDRPESAALLPALATGALPEAVLRAGRVLVPGLHRVAAPSTGGTALDPGGTALITGGSGALAALLAEHLVRAHGVRSLVLLSRSGRGPDVPGADVRHVRGDVADRADVVAALAAVPPDRPLTLVAHLAGVLDDGALTSLTPERLDAVLRPKAEGARHLDELTRDRDLAAFVLFSSVAGALGHAGQANYAAANAHLDGLAHERHALGLPATALAWGPWTEGMARGRGGGLSPQVALGLFDAALRTGLPALVPLDREPERRVPAPRAATPAPAGPSLADRLRPMPPAERRAHLLELVTAEALGVLGHDDGAALPAGQAFRDAGFDSITAMALRNRLVRLAGVRLPASVVFDHPTPAATAERLEAELFPAEQLPGPRHGDDFDDMAADELVRRALGGEWPTPLGGPA
>CP029607.1|AXX30593.1|3843721_3853150_+|Malonyl-CoA-acyl-carrier-protein-transacylase
MTTREQLLDALRASLRENERLRATGGAAQPVAIVGAACRFPGGVTSPEELWDLVVGEVDAAGPFPDDRGWDLADLFDPDPDRVGRSYVRHGAFLRDMAWFEPGFFGISPREALVIDPQHRLLLEVAWEAFERAGIAPDSVRGRDVGVFGGVLNHDHGSRFRPVPPELEGYLGTGSSGSAAIGRVAYTLGLEGPAITVDTACSSSLVAIHLAVRALQRGECSMALAGGVTVMSTPDTFVEFSRQRALARDGRCKAFSADADGTAWGEGAGLVLLQPLSAARRDRRQVLAVVRGSAVNSDGASNGLTAPSGPAQQRVIRAALADAGLSAADVDLLEAHGTGTVLGDPIEAQALLETYGRARADAGPLWLGSVKSNIGHTQGAAGVAGVLKVVQALRNGVLPPTLHAATPTTEVDWDAGAVRVLDRARPWRGGGEPGGARGGAAGGVEGGAAGGAAGGAAVRLRRGAVSAFGASGTNAHLILEEAPAVEAGALGATGALAATGASGVTGALGATGASGVTAAGTSTATAAAPGEELGATLGGAVAGGAEAAPPPASPPPAALPPAAFPPAAFPLGGPPTGAPAAVPSAPLPAAASDAPAPVPVPVPVPVPVAVSGATTAGLRAQAARLAGHLRERPALGPEAVARPLLLSRAQRERRAVVVAADRDSLLTGLDALAGGEAGPRLASGAADVTGRVVLVFPGQGAHWTGVAERLWREAPVFADSMARCADVLRDLAGWELREVLVDPVALERVDVLQPVSFAVVVSLAALWASVGVRPDAVVGHSQGEVAAAHVAGALTLAEAARIVVLRSALIARELSGRGAMLTVVADVERVTALLAGFEGRVCVAAVNGPASVTVSGEDGAVREFERVLSARRMLRWRLPGVDFAGHSPQVDALRAELLAALGDIASREPEIPLLSTVTGEPATRLDAEHWYRNLREPVRFADAVTALLDRGHRVFVEVSPHPVLTTSVVDLAAPHRTAVVGTLRRDEGGLDRFLLSAAELHVRGVPVDLARHAGAGTAEVPTTAFQRERYWLDAPRPSGDARAAGLVPSGHPLLGALVPLADGTVLTGRLSLSAQPWLADHRVLGAVVVPGVALVELAVRAGDEVGCPALEELVVAAPLVVPESGDVAVRVVVGPRGADGTRPVDVLSGDESPVLHARGVLAPPRAPEAVGGQWPPAGAEPVDLAGLYPDFAAKGLEYGPHFQRLTRLWRCGDEVFGEVELTGEQRRAAGFALHPALLECALHASSFAGQRVAGDGGAVGLPFSFSRVALHRSGVDAVRVRATRVGDGVVSLALADGAGRPVARIGELAFRRAVGIRSGPPGVLLETAWRPVELPEARPAADVTTVVGDSVERVLAALRETLAGDGRLLVLTGGPGAPIGTAVGAAVWGLVRSAQLEEPGRIVLADLDTTPELAAPALRRVLASGEPQVAIRAGAVLVPRLTPVAAVARPAGLDPAKTVVLTGGTGALGRLVARHLVTDHGARKLLLLGRGGPERARDLVAELTGLGAEVEALACDVADRDALSAALAGRALTAVVHLAGALDDGVVTALTPERLAVAFAPKALAARHLDELTRDQDLAAFVLFSSAASVLGSAGQANYAAANGFLDGLAHERHALGLPATSIAWGLWDVDSALVGERGAADRERLAASGMRPLPAPAALDLLDAALACGRPAVTALALARAADRAPTALSEVVTPRRTPAPAAPVAGDPAALLALVRAEAAAVLALPVAGVDERRAFRDLGLDSLTGVELRNRLAEATGLRLPATLVFDHPTPVELAAALLERVGGATGPAGGRPGATAGAGPAAALGAGPGTAPVPGEPIAIVGMACRAPGGVASPEDLWDLVAGGVDAVGPFPADRGWDLERLVHPDPDHEGSTYVDRAAFLDDPAGFDADFFGISPREALAMDPQQRLLLEVAWEAFERAGIAPDSVRGTDVGVFAGVTNHDYDQVLPRGDDGYRITGVSGSVVSGRIAYALGLEGPALSVDTACSASLVAIHLAVRALRGGECSMALAGGATVMATPRGFVEFARQRGLAPDGRCKSFAEGADGTAWSEGAGLVLLERLSDAQRNGRRVLAVVRGSAVNSDGASNGLTAPSGAAQQRVIRAALADAGLSTADVDAVEAHGTGTRLGDPIEARALVATYGRDRDGEPLWLGSLKSNLGHMQGAAGIGGVVKTVQALRHGVLPRTLHVDAPTPEVDWEGVAVLAEQRDWPEVGRPRRAAVSSFGVSGTNAHVVLEQAPAEIVAETAVETADRAQDLPGVLPLVLSARSPAALRAQAARLADVLDDLPLRDVASTLARGRAAHEHRAVLVAADRDALRAGLRALAGGRPHAAARTGVRAPGGLAFAFSGQGSQFVGMGRGLHAAFPAFAEVFDRVCAALDERLGDLTGRSVRDVVLDGPAELLVETVHAQPALFALEVALARLLERWGVVPDVVLGHSVGELAAAHVAGALSEADACALVAARARAMHGARRGGAMLAVAATEEQVAPLLGGGLALAAVNGPGAVVLSGDGDAVERAAAECAGRGWRTRALRVSHAFHSAHLDGVLGELALAARRVEVLPPRVPLLSTLTGAPADAELLADPDYWVRQARHAVRFGDGVARLGELGVTRVLEVGPGGALAALVREQVAPGTAVARGLVDGDEVVGLLSGIGDLVASGAPVDWTALLGGPGAVADLPTYPFQRTRFWPVAQAAGAWCEVRHERLPAPRGDGSATVLEVGPTASAEELAGVADVLAGHGGPLLVVTGDGAVAGLVRSLPDRADVVLADVDDDPASVALLPALHGCGEPEVVVRAGEVLAPRLRRVTATSAVPAGPVLVVGEAARGVVAACGVREPVVLPADPGREELVAALEGHRPDWVVLAVEPDDAGLARAALLDELTRDRPPALFALCGPAGALGDAARPEDAVAAGVLAALVRRRHEDGLPATLLCAGPGVPPLSPELGVVVFARTSEAALSGGVLSEGALPGVALPEQRSAPEPSAVDLTGPDRDRVLLALVRDHAAAVLGRADGSVDGRAAFRDLGFDSMTAVELRDRLAAATGLTLPATLLFDHPTAAEVAAVLAGLLDGGDPVTSGLDRLEAALADPPADPALRASAAARLRALLAALSDEDQGEPDGGAALRDAGVAELFEFIDTRLGRAERT
>CP029607.1|AXX30594.1|3853112_3853271_-|hypothetical-protein
MRVRRGPGDGEQNAQLSSSVLGPAARRAPVVKGRGCGPEPVRSARRGPAGCR
>CP029607.1|AXX30595.1|3853226_3854435_+|putative-glycosyltransferase
MRVLFTVTGAPSHAHEMLVLGRAVLDAGHEVLVATAPSAAPGLRGSGLPSVEALPDQARFWVERLGGVVPPARPGTDYPGVDAIVDVIAGRPLLREALAGLRPVVDRFRPDLVLRDGMELAGLLVAEERGLPCLTVPSGTTNQLDPAAVLPRLNERRAEQDLPTSADPLSAHRHGHVDCLPREYSLLGVPLSPCLAYRPPSPEGRSLPAWLADLDPSRPLVYGAVGIALAATWRRDDVTALAADPVEALSGLVAALSEVDCAAVVSTGGIPVDRVPPGAPHVRVVERAPQPLLLECAQLFVTHAGANSVREAVRAGVPMVAAPLFGDQPHNAARVAALGLGVRVVDGSPADLADACRTVLADPGFTARARHARRTLLALPPVGEVVTRLEQIAEAARSVAAV
>CP029607.1|AXX30596.1|3854702_3855728_+|3-oxoacyl-[acyl-carrier-protein]-reductase
MPRRLAEQVVVVVGASSGIGRVTALRFAAAGARVVCAARNTRALDGLVEEVRDAGGPAVAVTADIADEAAVRAVAEVAVERFGRVDTWVNAAGIGVYGRVEDTPAEEFDRVMRVNYLGHVHGAKAALPALRRAGGGVLIGVASVLGLRSAPLQAPYAASKAAVRAFYDALRVELAHDGEPIAVTAVLPAAINSPFFEHCRSRVGSLPEPPPPVYAPELVAEAVLRAAERPRREVPVGDAALAFYLGQRLFPALTDALMSVRAVGRSGMRSELPDNGVDNVDSPVDEDGRVHGAYPGRVLESSPVTALLARAPRPGELVTSLVSGAHRVTGAVRDGVRAARS
>CP029607.1|AXX30597.1|3855807_3856272_-|hypothetical-protein
MTDTTTRHRTPVQNAALAVGAVFLLVGIAGFVPGLTTDYDDLAFAGHHSDAALLGVFKVSALHNLVHLAFGAAGIATGLSKAPRGARAFLIGGGAIYAVLWLYGVVVDEHSTANFVPFNAADNWLHLGLAVGMIGLGAALGRNAAHYRAAQSDD
>CP029607.1|AXX30598.1|3856453_3857074_-|Transcriptional-regulator,-TetR-family
MSTAQDARAGRKHVSAAVRREQLVAAALRVMKRDGIAAATTRAICAEADMPHGAFHYCFRSKQELHTALLTTGLNTSLDAAWPSISPDLPAVDNVRTMLDAFWTAFQADPEAELVLGELVTLARREPELRELPAWQHREYVAKAVAHLDRLAEEAGFDYSVDRALLAELVVSVLDGVASSWFSHRDGELARASLDQFAVMFATLTR
>CP029607.1|AXX30599.1|3857116_3857692_+|cytochrome-P450
MVTWPTLRPQAPAPGGNLLDVLTSDLDTDVDFLDRCHREHGGIVALTFAGQRQVFASSHELVAARAALPAGERPDDLLERMLTSADPVTGGRLSARNVRHQLATFLIACHETTSGLLSFAVHRLLAHPDVLCKAKEAVDEVLGDRVPGFADLARLDHLGQVLRETPRLLRPAARRSAEGRCSRCPARGTGS

Crispr_ID: CP029607_5

• CRISPR_ID: CP029607_5
• CRISPR_location: 6450536-6451111
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 11 spacers

Consensus repeat of CP029607_5

Consensus_repeat	Method
GACGGTTGAACGGACCGTTCAACCG	CRISPRCasFinder

spacers of CP029607_5

>5.1|6450561|38|CP029607|CRISPRCasFinder
TGGTTGAACGGTCCGTTCAACCGAGAGCGAGCAAGCTC
>5.2|6450624|17|CP029607|CRISPRCasFinder
AGTTCGAGCGTGGGTAC
>5.3|6450666|17|CP029607|CRISPRCasFinder
GGTTCAAGGATAGGCAC
>5.4|6450708|36|CP029607|CRISPRCasFinder
AGCACGAGCGCAAGCACTGGCACCGGCCTCAGCAGC
>5.5|6450769|17|CP029607|CRISPRCasFinder
GGTTCGAGCGTGGGCAT
>5.6|6450811|17|CP029607|CRISPRCasFinder
GGCTCAAGCACAGGCAC
>5.7|6450853|17|CP029607|CRISPRCasFinder
GGCTCAAGCACATGCAC
>5.8|6450895|42|CP029607|CRISPRCasFinder
CGCCCCGCTGAACGGTCCGTTCAACCATGCCCAGTTGACATG
>5.9|6450962|16|CP029607|CRISPRCasFinder
CCTCCAGTTGCTCACA
>5.10|6451003|30|CP029607|CRISPRCasFinder
TGTGTAGGTGAGCGGGCCGTTCACTCACCC
>5.11|6451058|29|CP029607|CRISPRCasFinder
GGGGGTGAGCGTGAGCGCAGGTACGGGCT

CRISPR arrays and Neighbor proteins around CP029607_5

CRISPR arrays

The CRISPR arrays of CP029607_5

>merge|CP029607|5|6450536-6451111|CRISPRCasFinder
ACCGGGTGAACGGCCCACTCACCCATGGTTGAACGGTCCGTTCAACCGAGAGCGAGCAAGCTCGCCGGTTGAACGGACCGTTCAACCGAGTTCGAGCGTGGGTACGGCGGTTGAACGGACCGTTCAACCGGGTTCAAGGATAGGCACGGCGGTTGAACGGACCATTTAACCGAGCACGAGCGCAAGCACTGGCACCGGCCTCAGCAGCGGTGGTTGAACGGTCCGTTCAACCGGGTTCGAGCGTGGGCATGACGGTTGAACGGACCGTTCAACCGGGCTCAAGCACAGGCACGACGGTTGAACGGACCGTTCAACGGGGCTCAAGCACATGCACGACGGTTGAACGGACCGTTCAACCGCGCCCCGCTGAACGGTCCGTTCAACCATGCCCAGTTGACATGCCCAGTTGAACGGGCCGTTCACTCACCTCCAGTTGCTCACACGCAGTTGAACGGACCGTTCAACCATGTGTAGGTGAGCGGGCCGTTCACTCACCCCCTGGTTGAACGGTCCGTTCAACCAGGGGGTGAGCGTGAGCGCAGGTACGGGCTGAGGGGTGAACGGGCCGTTCAACCG

>CP029607|5|4|6450536-6451111|CRISPRCasFinder
ACCGGGTGAACGGCCCACTCACCCA	TGGTTGAACGGTCCGTTCAACCGAGAGCGAGCAAGCTC
GCCGGTTGAACGGACCGTTCAACCG	AGTTCGAGCGTGGGTAC
GGCGGTTGAACGGACCGTTCAACCG	GGTTCAAGGATAGGCAC
GGCGGTTGAACGGACCATTTAACCG	AGCACGAGCGCAAGCACTGGCACCGGCCTCAGCAGC
GGTGGTTGAACGGTCCGTTCAACCG	GGTTCGAGCGTGGGCAT
GACGGTTGAACGGACCGTTCAACCG	GGCTCAAGCACAGGCAC
GACGGTTGAACGGACCGTTCAACGG	GGCTCAAGCACATGCAC
GACGGTTGAACGGACCGTTCAACCG	CGCCCCGCTGAACGGTCCGTTCAACCATGCCCAGTTGACATG
CCCAGTTGAACGGGCCGTTCACTCA	CCTCCAGTTGCTCACA
CGCAGTTGAACGGACCGTTCAACCA	TGTGTAGGTGAGCGGGCCGTTCACTCACCC
CCTGGTTGAACGGTCCGTTCAACCA	GGGGGTGAGCGTGAGCGCAGGTACGGGCT
GAGGGGTGAACGGGCCGTTCAACCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP029607.1|AXX32712.1|6448987_6449545_-|Transcriptional-regulator,-TetR-family	unknown	unknown	gnl|CDD|184958
CP029607.1|AXX32713.1|6449633_6450473_+|putative-methyltransferase	unknown	unknown	gnl|CDD|379312
CP029607.1|AXX32716.1|6454222_6454639_+|putative-transcriptional-regulator-of-pyridoxine-metabolism	unknown	unknown	gnl|CDD|373064
CP029607.1|AXX32719.1|6456842_6458234_+|L-fuco-beta-pyranose-dehydrogenase	unknown	unknown	gnl|CDD|237218
CP029607.1|AXX32721.1|6458321_6461783_+|Superfamily-I-DNA-and-RNA-helicase-and-helicase-subunits	unknown	unknown	gnl|CDD|274603
CP029607.1|AXX32710.1|6447616_6448291_-|hypothetical-protein	unknown	unknown	gnl|CDD|377627
CP029607.1|AXX32711.1|6448360_6448933_-|Isopentenyl-diphosphate-delta-isomerase	unknown	unknown	gnl|CDD|235156
CP029607.1|AXX32709.1|6447209_6447617_-|hypothetical-protein	unknown	unknown	gnl|CDD|341119
CP029607.1|AXX32714.1|6451346_6452321_-|Alcohol-dehydrogenase	unknown	unknown	gnl|CDD|176237
CP029607.1|AXX32707.1|6446296_6446680_+|Transcriptional-regulator,-HxlR-family	unknown	unknown	gnl|CDD|224647
CP029607.1|AXX32723.1|6463279_6464257_-|Sorbitol-dehydrogenase	unknown	unknown	gnl|CDD|176196
CP029607.1|AXX32722.1|6462462_6463113_+|hypothetical-protein	unknown	unknown	gnl|CDD|226406
CP029607.1|AXX32708.1|6446676_6447006_-|hypothetical-protein	unknown	unknown	gnl|CDD|380457
CP029607.1|AXX32720.1|6458197_6458362_+|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX32706.1|6445316_6446153_-|Enoyl-CoA-hydratase	unknown	unknown	gnl|CDD|119339
CP029607.1|AXX32718.1|6455472_6456669_-|hypothetical-protein	unknown	unknown	gnl|CDD|375603
CP029607.1|AXX32705.1|6443718_6445200_+|hypothetical-protein	unknown	unknown	gnl|CDD|237408
CP029607.1|AXX32715.1|6452414_6453344_+|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|378976
CP029607.1|AXX32717.1|6454717_6455476_-|hypothetical-protein	unknown	unknown	gnl|CDD|375611
CP029607.1|AXX32704.1|6442992_6443649_+|Putative-phosphopantetheinyl-transferase-PptA	unknown	unknown	gnl|CDD|225524

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP029607.1|AXX32712.1|6448987_6449545_-|Transcriptional-regulator,-TetR-family	gnl|CDD|184958	PRK14996, PRK14996, TetR family transcriptional regulator; Provisional.	0.000193479
CP029607.1|AXX32713.1|6449633_6450473_+|putative-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.77824e-15
CP029607.1|AXX32716.1|6454222_6454639_+|putative-transcriptional-regulator-of-pyridoxine-metabolism	gnl|CDD|373064	pfam14430, Imm1, Immunity protein Imm1. A predicted immunity protein, with an alpha+beta fold and a conserved C-terminal tryptophan residue. The protein is present in a wide range of bacteria in polymorphic toxin systems as an immediate gene neighbor of the toxin gene.	4.39929e-24
CP029607.1|AXX32719.1|6456842_6458234_+|L-fuco-beta-pyranose-dehydrogenase	gnl|CDD|237218	PRK12825, fabG, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	1.37045e-14
CP029607.1|AXX32721.1|6458321_6461783_+|Superfamily-I-DNA-and-RNA-helicase-and-helicase-subunits	gnl|CDD|274603	TIGR03491, TIGR03491, RecB family nuclease, putative, TM0106 family. Members of this uncharacterized protein family are found broadly but sporadically among bacteria. The N-terminal region is homologous to the Cas4 protein of CRISPR systems, although this protein family shows no signs of association with CRISPR repeats.	5.55529e-63
CP029607.1|AXX32710.1|6447616_6448291_-|hypothetical-protein	gnl|CDD|377627	pfam06197, DUF998, Protein of unknown function (DUF998). Family of conserved archaeal proteins.	8.45604e-07
CP029607.1|AXX32711.1|6448360_6448933_-|Isopentenyl-diphosphate-delta-isomerase	gnl|CDD|235156	PRK03759, PRK03759, isopentenyl-diphosphate Delta-isomerase.	1.73046e-95
CP029607.1|AXX32709.1|6447209_6447617_-|hypothetical-protein	gnl|CDD|341119	cd17036, T3SC_YbjN-like_1, T110839 is structurally similar to type III secretion system chaperones and YbjN family proteins. This family includes protein T110839 from Synechococcus elongatus that is structurally similar to type III secretion system (T3SS) chaperones (T3SC) that bind effector proteins, and is homologous to YbjN, a putative sensory transduction regulator protein found in Proteobacteria.	0.0013363
CP029607.1|AXX32714.1|6451346_6452321_-|Alcohol-dehydrogenase	gnl|CDD|176237	cd08276, MDR7, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	5.5925e-130
CP029607.1|AXX32707.1|6446296_6446680_+|Transcriptional-regulator,-HxlR-family	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.92859e-34
CP029607.1|AXX32723.1|6463279_6464257_-|Sorbitol-dehydrogenase	gnl|CDD|176196	cd08234, threonine_DH_like, L-threonine dehydrogenase. L-threonine dehydrogenase (TDH) catalyzes the zinc-dependent formation of 2-amino-3-ketobutyrate from L-threonine, via NAD(H)-dependent oxidation. THD is a member of the zinc-requiring, medium chain NAD(H)-dependent alcohol dehydrogenase family (MDR). MDRs have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit. Sorbitol and aldose reductase are NAD(+) binding proteins of the polyol pathway, which interconverts glucose and fructose.	9.66875e-173
CP029607.1|AXX32722.1|6462462_6463113_+|hypothetical-protein	gnl|CDD|226406	COG3889, COG3889, Predicted solute binding protein [General function prediction only].	7.61404e-05
CP029607.1|AXX32708.1|6446676_6447006_-|hypothetical-protein	gnl|CDD|380457	cd19534, E_NRPS, Epimerization domain of nonribosomal peptide synthetases (NRPSs); belongs to the Condensation-domain family. Epimerization (E) domains of nonribosomal peptide synthetases (NRPS) flip the chirality of the end amino acid of a peptide being manufactured by the NRPS. E-domains are homologous to the Condensation (C) domains. NRPSs catalyze peptide bond formation within (usually) large multi-modular enzymatic complexes. Specialized tailoring NRPS domains such as E-domains greatly increase the range of possible peptide products created by the NRPS machinery. NRPS can use a large variety of acyl monomers (approximately 500 different possible monomer substrates as opposed to the 20 standard amino acids in ribosomal protein synthesis) to construct bioactive secondary metabolites of 2 to 18 units long (with various activities such as antibiotic, antifungal, antitumor and immunosuppression). There are various subtypes of C-domains such as the LCL-type which catalyzes peptide bond formation between two L-amino acids, the DCL-type which links an L-amino acid to the D-amino acid at the end of a growing peptide, starter C-domains which acylate the first amino acid with a beta-hydroxy carboxylic acid, and heterocyclization (Cyc) domains which catalyze both peptide bond formation and cyclization of Cys, Ser, or Thr residues. Typically, an NRPS module consists of an adenylation domain, a peptidyl carrier protein (PCP) domain (also known as thiolation (T) domain) and a C-domain. NRPS modules may also include specialized domains such as the terminal-module thioesterase (Te) domain that releases the product via hydrolysis or macrocyclization and any of various C-domain family members such as the E-domain, the ester-bond forming C-domain, dual E/C (epimerization and condensation) domains, and the X-domain. C-domains typically have a conserved HHxxxD motif at the active site; mutations in this motif can abolish or diminish condensation activity.	0.000687645
CP029607.1|AXX32706.1|6445316_6446153_-|Enoyl-CoA-hydratase	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	1.72221e-36
CP029607.1|AXX32718.1|6455472_6456669_-|hypothetical-protein	gnl|CDD|375603	pfam18171, LSDAT_prok, SLOG in TRPM, prokaryote. Family in the SLOG superfamily, fused to or operonically associating with SLATT domain in diverse prokaryotes. Predicted to function as ligand sensor in conjunction with the SLATT transmembrane domain.	1.88906e-52
CP029607.1|AXX32705.1|6443718_6445200_+|hypothetical-protein	gnl|CDD|237408	PRK13517, PRK13517, glutamate--cysteine ligase.	4.13285e-08
CP029607.1|AXX32715.1|6452414_6453344_+|AraC-family-transcriptional-regulator	gnl|CDD|378976	pfam12852, Cupin_6, Cupin. This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily. Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.	2.87333e-35
CP029607.1|AXX32717.1|6454717_6455476_-|hypothetical-protein	gnl|CDD|375611	pfam18181, SLATT_1, SMODS and SLOG-associating 2TM effector domain 1. The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is often C-terminally fused to the SLATT_3 family, and is typically operonically linked to either inactive TIR domains or SLOG domains which could act as regulators of the SLATT channels. In relatively rare instances, it is genomically linked as a standalone domain to the RelA/SpoT nucleotide synthetase and the predicted NA37/YejK sensor domain.	0.00644876
CP029607.1|AXX32704.1|6442992_6443649_+|Putative-phosphopantetheinyl-transferase-PptA	gnl|CDD|225524	COG2977, EntD, Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism].	1.46228e-62

Protein sequences

>CP029607.1|AXX32713.1|6449633_6450473_+|putative-methyltransferase
MPIHESPHDAREIAESFGTDADRYDRTRPSYPSGVVEAVLAALSGGVGVGGGAGVGDAPGVLDVLDVGCGTGIVARQFRDAGCRVLGVEPDARMAEFTRRGGIPVEVARFEEWETAGRRFDAAVCGQAWHWIDPDAGAARAADVLRPGGVLTIFWNAARVAGEVGERFDEVYRGLLPGDLGKGAGAFGGDYSPLGDRAVVGIKTTNAFEEPIRLRFPWERVYQRDEWLDLLPTTGLFTRMPRELLTRVLDEVGATIDSVGGELTVTYTCETVIARRSAE
>CP029607.1|AXX32712.1|6448987_6449545_-|Transcriptional-regulator,-TetR-family
MAIQDARNQLFDAAERVLLRDGPSGLTSRAVTTEASFAKGVLHRHFADFDAFLAEFVLDRAARPTPEVESLPDQVGRAEVVDNLTSALTALYASAAVAVVPLLTFRTALRDRLRDAWPAGVPVLTDAAVRITAYLDAERAAGRLPDTLPADALGPALVGSTHLLHTGPGATEDAVRRVVATVLRV
>CP029607.1|AXX32711.1|6448360_6448933_-|Isopentenyl-diphosphate-delta-isomerase
MERVVLLDETGAAVGEADKATVHHEETPLHLAFSSYLFDRGGRLLLSRRALHKKTWPGVWTNSCCGHPAPGEDLEAGVRRRLAEELGLPDVGLDLVLPGFRYRAVMDNGVVENEMCPVYRGVIDTEPAPNPDEVDDVEWVPWADFAPAVLSGARPISPWCLLQVEALAELGDDPLKWPVGSPADLPLAVR
>CP029607.1|AXX32710.1|6447616_6448291_-|hypothetical-protein
MLNAETAAPSRFVGPGGALAVVLTVALIGGLDLHRAVTNPYSLRRTISEYALGPQKWVFDVGVLLLAAGSVAILVALVRAGVARWWSPGAVAMALWSAGLTLVVLFPKHNWAMGGPSASGTVHRVASVLAFLSLPVAALLLSRPWLRSAAWGAHARRVFALGWLSVLALSPLVYALLVDASGGTAWWRVFPLGYVERVLVLVEVVAVLAAGSWAIAVGKRPRVA
>CP029607.1|AXX32709.1|6447209_6447617_-|hypothetical-protein
MATWGDLAAYVRDQYDVIAQEDDEIRILFTFDHLDEEDERTQVIILVREVLDRKHEWVQIATPMGLASAVDLKALLEEIGHSSIACGAAIMGEHVVLRHSLPLQTLDIHEFTDPLALVAGTADTLEEQFFGGDNY
>CP029607.1|AXX32708.1|6446676_6447006_-|hypothetical-protein
MSTTPVVPAASYESMTVRVRAGLGEDRLAAAVEALTARHSELSDGGTSSRRVVVGGDPARARGGEALSVVWVDAGAEPGRLVLSARQDVLAALPWRVLLPELASEWKTH
>CP029607.1|AXX32707.1|6446296_6446680_+|Transcriptional-regulator,-HxlR-family
MGDGRAIGSREAPEFRVDCPSRPILDQIADKWSMMALAVLEDEPRRFNDIKRRLEGVTQRVLTHTLRRLERNGMVERRVLPTSPVGVEYALTPLGRSLREPFWQLLEWTLEHSGEVERARRAYDGER
>CP029607.1|AXX32706.1|6445316_6446153_-|Enoyl-CoA-hydratase
MTHAPLRVRAENGVVRVTVDNPPVNVLDARLITELKRLLVALRSDESARVIVFDSADPEFFLAHVDMTTTPEQVVELSADLPEGVNAFQALGELLRGQPQVSIVKLAGKARGGGAEFVAAADLVFAAIGRAGLGQVEAPGGIVPGGGGTQYVTARTGRNRALEIVLGADLFDAETAERYGWVNRALPADELDAFVDRLAANIAALPEGVIAATKRAIPAEDLSAGLVREHEEWAGLFARPAAGELLAGMMAAGAQTREGERDLEGLARGVGARVAAKG
>CP029607.1|AXX32705.1|6443718_6445200_+|hypothetical-protein
MGDDVERHEFSREDRTRYRTKVRRCLDVFTRMLEEERFEVDRPMTGLEIELNLVDEAGDPAMRNAEALEAIADPDFVTELGQWNVEINVPPRELAGGGFAELEATVRTSLNQAEKRAREVDAHMVMVGTLPTLQARHMAVDALSGNPRYALLNEQVLAARGEDLEINVDGAERLQMTADSIVPEAACTSTQFHLQVSPERFPAYWNAAQAIAGVQVAVGANSPFLLGKELWPETRIALFQQATDTRSDELKEQGVRPRVWFGERWITSIFDLFEENVRYFPALLPICAEEDPERVLADGGVPSLAELRLHNGTIYRWNRPVYDVVDDRPHLRVENRVMPAGPTVVDTMANAAFYYGLAHALAQDERPVWSQMSFSAAEENFLAGARRGIDAQVYWPGLGTVPVVELVLRRLLPLAHEGLVGLGVDERERDRLLGIVEQRCLRGVNGATWQTRAFHRAYDGTSLERPEALRRVLRGYRDLMHTNEPVHSWPVAG
>CP029607.1|AXX32704.1|6442992_6443649_+|Putative-phosphopantetheinyl-transferase-PptA
MIEELLPDGVAAVEAFGDPPEAVLLPEEEEHVARAVDKRRREFTTGRHCARGALAKLGFPPVPLLPGPKREPGWPEGVVGSITHCNGYRAAVAARTEAVWTLGIDAEPNQPTPEGVLAAVALPREQDMVALLGGRDSSVHWDRLLFSAKESVYKSWFPLTRRWLGFEDAELVLGRDGTFTARVLVEHPVVDGRVVSGFTGRWLAREGFVVTAIAVPAR
>CP029607.1|AXX32714.1|6451346_6452321_-|Alcohol-dehydrogenase
METPMRAFRLTDHRWTPVDEPTPTPGPGEVLVKVKAASLNHRDVLIRAGNYAAQPTPGVIPLSDGAGEVVALGDDVTRFAVGDRVVGAFLPGWTTQPVPTSGEQYSIDVDGWLAEHRVIPEEALAAIPTGVDDETAATLPCAATTAWVALHGVGEGDVVLTQGTGGVSLFVVQLAVARGARVVATTSTAPKADLLATLGAEVINRVTTPDWPSEVWTRFGGAHRVIEVGAGLTRSLSALRPFGEVALVAPSREEVRTSTIFRTRATLRSLAVGNRLELEAVAAEVARLNLRPVIDGVFDFEDAENAHARQTEDDRVGKIVIRVG
>CP029607.1|AXX32715.1|6452414_6453344_+|AraC-family-transcriptional-regulator
MDPVDDILTTMGLAHRSHHRVTASAPWGVAFSGAAPMRLVVVARGRCVLSEGGGVVELGAGDCLVVRGGAEFVLSDVAERVPAPAREVLTAREVAVGGGGAGCEVLVAAFSFDAVAAEPLLPRLPDVLRVSLRGGNLRRVLATVELMVLESGDGFGSELVLGKLGDVLLVQVMRAWCAGSGDDRPGWLAALHDPRLSLAMRAMHGDLAHPWTVASLAGRAGMSRSAFAAAFRERTGESPLAHLTYWRMHRAKALLREGRTLQEIAVRVGYETDTALSRAFRRAEGVSPGRWRGLVARVGDSGGEACPVA
>CP029607.1|AXX32716.1|6454222_6454639_+|putative-transcriptional-regulator-of-pyridoxine-metabolism
MVELEAWYGEDQDEPVLVRTGAELDAVLDEVAGMCGRIIVHLKVSDPPSLDVRLMVLDVGLHGDAGTGALFYQSRSGSWFSRGAAPDPSVSELLYYYMNSDTEYPLDCEIPIDAVRRAAHEYRSAVDARPSAPGWQPA
>CP029607.1|AXX32717.1|6454717_6455476_-|hypothetical-protein
MSGDGITDRLGGGDQARKKGRPLRGAPTGRLRDEDVPDPTARVALEPQGEPDDATRAVPVDGVRGRHAARAATPGAPDPDEKPARAPRKPAKPRVAKQPNPALLTPPPRRTPLVTGPVSAADHREQFLRAYLRHRVGERLARLEAAKAAYTRARRWTTTASVLLFTGAAALGALAVATPDHRSPLAFLATVAAALATSVTVYESAFGFRAKARRSASGAALLHLLQAHGAPTGDHGVAAFRAEVESVLRHAD
>CP029607.1|AXX32718.1|6455472_6456669_-|hypothetical-protein
MRRLAHPDADIRARALGLPRGRPVVALLGSPEPLDPELSATVLPVLRTVLSEARRAGAVVLTTGADLGVAHLTGLASEALDGAGPRLVGIAPGRLVAADDAEPRPGELPLNQRHDTAVLVPGSRWGDEVPALLRVVDAVARKRPALVVLLGGDEGARAALVEHLGHDRPLLLLAGTGGLADELVSGALADEDIGVLARAGQVAVVHVDEGPERVLAVLRGVLGSKAGTPLRADVPTLALWPRLRFRAPDARPVVDPGFVLDYPLLADAIHEANEVIAPALHECEVESLRARERGRLLASAAILAGFATTSFAALQVWLRDVPWPGVLVAVAGAAAAVLAVVSRGADDVEFRSRAELLRALYFDHLSTPPPKNEAEREERVRALVTAVARHRHEPVGAA
>CP029607.1|AXX32719.1|6456842_6458234_+|L-fuco-beta-pyranose-dehydrogenase
MPGIDPAEMEIALRVLAQVDDLPPEHPDTIALRRATSRIYKQVRKNRKTARRQEVLDADNSVIAATATGSPTRIDDETAGILLREPDPGESAGTFRKARPCYICKQRYTQVDAFYHQLCPKCAALNRAKRDARTDLTGRRALLTGGRAKIGMYIALRLLRDGAHTTITTRFPHDAVRRFASMPDSGDWLHRLRVVGIDLRDPAQVVALADSVAAAGPLDILINNAAQTVRRSPGAYAPLVAAESDPLPSGPLPELVSFGHSSAAHPPALTGGLPGGAGVDVTALALVAGSSLIDAGGLVPDVAESNSWVQTVGEVDPVELLEVQLCNSTAPFILVSRLRPAMAASQARRKYVVNVSAMEGVFGRGYKGAGHPHTNMAKAALNMLTRTSAADVFEDGILMTSVDTGWITDERPHFTKLRMAEEGFHAPLDLVDGAARVYDPVVRGEAGEDLYGCFLKDYGPYSW
>CP029607.1|AXX32720.1|6458197_6458362_+|hypothetical-protein
MLPEGLRPLFVVTDRSGRRGPVGKTPCPLHRSGQPGGDTAVHVQRQRQVRPLTG
>CP029607.1|AXX32721.1|6458321_6461783_+|Superfamily-I-DNA-and-RNA-helicase-and-helicase-subunits
MFSANGRYVHSPGDLVDLLECEHRSRLTTALTKGVPDAPQPAPPQDLLAARHGLAHEKAVLERFLAAGEVFEVPQPAPVHEALVEAAALTWDAIARRVPVIYQGVFYDGDFHGRADFLVLTEDGYEPHDAKLARHPTPAAVVQLTAYSAALGDQAGPKAHLLLGDNTARTFRVSDFLPIVADLRARLRATVAAPPALPARLWDDERPACATCRFSAHCADGRERSRDLSLVAGIRTDQRRKLASAGLDTIDALANATNTERPTTMSQGTFAGLRAQAALQVIQDTSRTRDNPVGKVAYEVVVPDALASLPQPSPGDLFFDMEGDPYALAGEGLEYLFGVVTHEEVFTPFWAHTRPQEKAAFERLVDLATSRLAEHPDAHVYHYAPYEVSALKRLAALHGTREEEVDHLLRSNALVDLYAVVRKALRVSQRSYSIKYLEPLYMPEARSGDVKNAVSSIEAYEEYLVLTSMGDTGRAEEVLDGIAEYNTYDCVSTLRLYRFLLQVREEAGIEPRTAEQSLYEEIEDEIAQQRRAERAERIAAVVDPLIEGLPDNPADFTDDERARALLAAAVGYHRRETNPAWWDFFRQLAAPLSELESDSSCAVAVSVRADDWVQPAGRVKKAKREVRVRCDPDRPHPFSKGEKVRLLYPGTPDSETRDAEVLFESADEVVLLESASPDEAGGGNPVAVLPGSPVRPAPKDEAVYELARLVVEHLPELPAHPGVDLARRLAPRLRAGSLPRSGDVIADVIGAVDALAGSVLAVQGPPGAGKTYLAGRLIAHLIAGGRSVGVTSNSHKAVENVLTAAIKAGRELGVPIPAAKNPKGQPVKDCLWEQTKNNPALLRWREDQGGGHLVGGTAWTFSNAAMREQPFDVLIVDEAGQFALADALAVSTAARNLVLLGDPQQLPQVVQGTHPAGADASALGHVIGDADVMPPELGYFLAQTRRMHPSVCLPVSNLSYAGLLHAHESAGGRRVVGIAPGLYVREVDHRHNTTKSDEEAAAVGELVAAIVGREWVDGDDRRPLECSDVLVVAPYNLQVRLVKRELERRGFGEVRVGTVDRFQGQEAPVVISTMTSSSAVDLPRGLDFLLSRNRVNVALSRAQALAVVVCSPRLVEADIRGVEQLRLVSGMIGLLGEARNWNNSPVAGGAAAG
>CP029607.1|AXX32722.1|6462462_6463113_+|hypothetical-protein
MALPASAHNRSLDVKCAPTGEAVFTLKLTQYSTRYDNTLKVTEGDTVLEDTTFKGNFVKEYKVPGDVARTFKVELVAGDDNSKSTYSFKAEKSLKELCKQPEKPSTTPETPKSEVPPTEDSVPPSPTSSSSPAPSVTESAPVPSSQEVPFPSVTESTSPAPTTTTSAEVVPVTEDTEGLANTGASVAVPLGIGAALLAAGGGVLFFMRKRGAANNG
>CP029607.1|AXX32723.1|6463279_6464257_-|Sorbitol-dehydrogenase
MITGVGSVEVTEVPDPTPGPREVVVDVAACGLCGTDLHILQGEFAPTLPVVPGHEFSGVIAEVGSDVTELKVGDRVAVDPSLYCFECRMCRLGKNNLCERWNAIGVTRSGGAAEFAVAPVSNCVKLPDSVRTEDAALIEPLSCAVRGYDVLRSQMASRVLIYGSGTMGLMMLQLGKLTGASSIEVVDLNPERLATAHKLGVTATAASADELDRPQGWDVVIDATGNAKAIQDGLGRVAKGGTFLQFGVSDYATRVTIDPYRIYNQEITITGSMAVLHSFERAADLFATGVLDPEVFISHREPLSSYASALEMFKNGQGRKIQVLP

Crispr_ID: CP029607_6

• CRISPR_ID: CP029607_6
• CRISPR_location: 6529189-6529275
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of CP029607_6

Consensus_repeat	Method
CGGGGCGTCGGGCCGGGGGCCTCGGGCCGGGG	CRISPRCasFinder

spacers of CP029607_6

>6.1|6529221|23|CP029607|CRISPRCasFinder
GCCTCGGGCCGGGGCGTCAGGTG

CRISPR arrays and Neighbor proteins around CP029607_6

CRISPR arrays

The CRISPR arrays of CP029607_6

>merge|CP029607|6|6529189-6529275|CRISPRCasFinder
CGGGGACGTCCGGTCGGGGCGTCGGGCCGGGGGCCTCGGGCCGGGGCGTCAGGTGCGAGGCGTCGGGCCGGGGGCGTCGGGCCGGGG

>CP029607|6|5|6529189-6529275|CRISPRCasFinder
CGGGGACGTCCGGTCGGGGCGTCGGGCCGGGG	GCCTCGGGCCGGGGCGTCAGGTG
CGAGGCGTCGGGCCGGGGGCGTCGGGCCGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP029607.1|AXX32768.1|6519123_6520023_-|putative-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
CP029607.1|AXX32770.1|6521364_6524253_-|Glycine-dehydrogenase-(decarboxylating)	unknown	unknown	gnl|CDD|235432
CP029607.1|AXX32786.1|6536000_6536738_-|hypothetical-protein	unknown	unknown	gnl|CDD|379556
CP029607.1|AXX32772.1|6525687_6526161_-|hypothetical-protein	unknown	unknown	gnl|CDD|376830
CP029607.1|AXX32784.1|6534200_6534830_-|membrane-protein	unknown	unknown	gnl|CDD|315961
CP029607.1|AXX32783.1|6533189_6534056_-|Mobile-element-protein	unknown	unknown	gnl|CDD|379129
CP029607.1|AXX32773.1|6526306_6527248_-|transcriptional-regulator,-MerR-family	unknown	unknown	gnl|CDD|133378
CP029607.1|AXX32785.1|6535014_6535896_+|putative-oxidoreductase	unknown	unknown	gnl|CDD|381391
CP029607.1|AXX32771.1|6524736_6525303_-|transcriptional-regulator,-MerR-family	unknown	unknown	gnl|CDD|133380
CP029607.1|AXX32776.1|6528286_6528898_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	unknown	unknown	gnl|CDD|223632
CP029607.1|AXX32774.1|6527281_6527734_-|hypothetical-protein	unknown	unknown	gnl|CDD|224630
CP029607.1|AXX32778.1|6529978_6530395_+|Anti-sigma-F-factor-antagonist-(spoIIAA-2),-Anti-sigma-B-factor-antagonist-RsbV	unknown	unknown	gnl|CDD|132914
CP029607.1|AXX32767.1|6518919_6519120_+|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX32782.1|6532726_6533026_+|WhiB-type-transcriptional-regulator	unknown	unknown	gnl|CDD|376791
CP029607.1|AXX32780.1|6531301_6531739_+|Serine-protein-kinase-RsbW	unknown	unknown	gnl|CDD|235217
CP029607.1|AXX32779.1|6530345_6531143_-|Serine-phosphatase-RsbU,-regulator-of-sigma-subunit	unknown	unknown	gnl|CDD|379279
CP029607.1|AXX32781.1|6531735_6532542_+|RNA-polymerase-sigma-factor-SigB	unknown	unknown	gnl|CDD|168831
CP029607.1|AXX32777.1|6529356_6529563_-|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX32775.1|6527847_6528228_-|Glycine-cleavage-system-H-protein	unknown	unknown	gnl|CDD|234918
CP029607.1|AXX32769.1|6520095_6521286_+|major-facilitator-superfamily-MFS_1	unknown	unknown	gnl|CDD|340863

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP029607.1|AXX32768.1|6519123_6520023_-|putative-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	3.8e-11	38.2	0.2

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP029607.1|AXX32768.1|6519123_6520023_-|putative-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	1.91331e-11
CP029607.1|AXX32770.1|6521364_6524253_-|Glycine-dehydrogenase-(decarboxylating)	gnl|CDD|235432	PRK05367, PRK05367, aminomethyl-transferring glycine dehydrogenase.	0
CP029607.1|AXX32786.1|6536000_6536738_-|hypothetical-protein	gnl|CDD|379556	pfam14325, DUF4383, Domain of unknown function (DUF4383). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length.	3.32021e-31
CP029607.1|AXX32772.1|6525687_6526161_-|hypothetical-protein	gnl|CDD|376830	pfam02577, DNase-RNase, Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site.	3.67624e-58
CP029607.1|AXX32784.1|6534200_6534830_-|membrane-protein	gnl|CDD|315961	pfam13398, Peptidase_M50B, Peptidase M50B-like. This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.	5.52888e-65
CP029607.1|AXX32783.1|6533189_6534056_-|Mobile-element-protein	gnl|CDD|379129	pfam13340, DUF4096, Putative transposase of IS4/5 family (DUF4096).	4.3378e-25
CP029607.1|AXX32773.1|6526306_6527248_-|transcriptional-regulator,-MerR-family	gnl|CDD|133378	cd00592, HTH_MerR-like, Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators. Helix-turn-helix (HTH) MerR-like transcription regulator, N-terminal domain. The MerR family transcription regulators have been shown to mediate responses to stress including exposure to heavy metals, drugs, or oxygen radicals in eubacterial and some archaeal species. They regulate transcription of multidrug/metal ion transporter genes and oxidative stress regulons by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	2.37233e-18
CP029607.1|AXX32771.1|6524736_6525303_-|transcriptional-regulator,-MerR-family	gnl|CDD|133380	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators. Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	9.19522e-22
CP029607.1|AXX32778.1|6529978_6530395_+|Anti-sigma-F-factor-antagonist-(spoIIAA-2),-Anti-sigma-B-factor-antagonist-RsbV	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	5.92073e-21
CP029607.1|AXX32774.1|6527281_6527734_-|hypothetical-protein	gnl|CDD|224630	COG1716, COG1716, FOG: FHA domain [Signal transduction mechanisms].	4.0446e-29
CP029607.1|AXX32776.1|6528286_6528898_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase	gnl|CDD|223632	COG0558, PgsA, Phosphatidylglycerophosphate synthase [Lipid metabolism].	7.83603e-22
CP029607.1|AXX32785.1|6535014_6535896_+|putative-oxidoreductase	gnl|CDD|381391	cd19752, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	1.54333e-123
CP029607.1|AXX32782.1|6532726_6533026_+|WhiB-type-transcriptional-regulator	gnl|CDD|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	7.71645e-26
CP029607.1|AXX32780.1|6531301_6531739_+|Serine-protein-kinase-RsbW	gnl|CDD|235217	PRK04069, PRK04069, serine-protein kinase RsbW; Provisional.	1.2429e-08
CP029607.1|AXX32779.1|6530345_6531143_-|Serine-phosphatase-RsbU,-regulator-of-sigma-subunit	gnl|CDD|379279	pfam13581, HATPase_c_2, Histidine kinase-like ATPase domain.	3.10265e-24
CP029607.1|AXX32781.1|6531735_6532542_+|RNA-polymerase-sigma-factor-SigB	gnl|CDD|168831	PRK07122, PRK07122, RNA polymerase sigma factor SigF; Reviewed.	9.56371e-122
CP029607.1|AXX32775.1|6527847_6528228_-|Glycine-cleavage-system-H-protein	gnl|CDD|234918	PRK01202, PRK01202, glycine cleavage system protein GcvH.	3.18599e-65
CP029607.1|AXX32769.1|6520095_6521286_+|major-facilitator-superfamily-MFS_1	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.50427e-39

Protein sequences

>CP029607.1|AXX32776.1|6528286_6528898_-|CDP-diacylglycerol--glycerol-3-phosphate-3-phosphatidyltransferase
MSTPPAAEPAPQDRYLTIPNALSVLRLLGVPVFLYLLLGPRADGWALVLLIAAGVSDWLDGKIARWLDQTSKLGVLLDPAADRLYIVATMIAFVVRDILPLWVVLVLVGRELVVGACLPVLRRLGYRAAFTITYLGKAATFILLYAFPMLLVAQGGSTFAQVIRPFAYAMMAWGAALYLWSGALYAYQLVLASRAQRPGVVSA
>CP029607.1|AXX32775.1|6527847_6528228_-|Glycine-cleavage-system-H-protein
MIPEELKYTEEHEWVQRTGETTVRLGITDFAQAQLGDVVFVQLPELGEKVSAGQTLGEVESTKSVSDIYAPLAGEVTARNDSLDQQPDLINEDPYGEGWMVELRLDDTDAFEGLLDAAAYQELVQE
>CP029607.1|AXX32774.1|6527281_6527734_-|hypothetical-protein
MSTNDGPGVPPEQSPERTSVFRADFLAEVEGAPASEPAVAGVDALPAGSALLVVKRGPNAGSRFLLDRDTTSAGRHPDSDIFLDDVTVSRRHAEFRREGGEFVVIDVGSLNGTYVNREPVDQAVLANGDEVQIGKFRLVFLTGPGAGGQG
>CP029607.1|AXX32773.1|6526306_6527248_-|transcriptional-regulator,-MerR-family
MTSAGRPQRGGMGIGAVLSQLRSEFPGVTISKIRFLEAEGLVRPARTASGYRRFSVSDVERLRYVLTAQRDRYLPLKVIREQLDAADDGLSGPAPAGPVPLSAERDVDHGRGEQVLAGRPWSTTRRPGGARSGDEVPAARDAEHPLPAGPAGPAPDRTAPARVAAPTAPAPRSELPTAADLAPAPGDRLSREDLLAQSGLDRAALAELERSGLLAPGPGGLHDPDALAVARTVRALARYGVELRDLRPARAAADRELATVERVLAPLRPGRDPRTRARADEVGREVAALLVALHTLLVRSGVRELAGDRVSPR
>CP029607.1|AXX32772.1|6525687_6526161_-|hypothetical-protein
MSEMRVVGVRVELPANQPILLLRETEGERYLPIWIGSVEATAIALEQQGVRPARPLTHDLLKDVIGALGRQLEQVRIIDLQEGTYFAELVFDGDIRVSARPSDSVALALRVGVPIHADEAVLAEAGLIIPDEQEDEVEKFREFLDSVSPEDFRGADT
>CP029607.1|AXX32771.1|6524736_6525303_-|transcriptional-regulator,-MerR-family
MVEEAPIRAGSGEQGELFPDSSLPDELVGYRGPAACQIAGITYRQLDYWARTGLVNPTIRSAHGSGSQRLYSFKDILVLKVVKRLLDTGVSLQNIRVAVDHLRERGVQDLARITLFSDGTTVYECTSPEEVVDLLQGGQGVFGIAVSGAMREISGTIHEFPAERADGTEIVVVAEDELAKRRRTRATG
>CP029607.1|AXX32770.1|6521364_6524253_-|Glycine-dehydrogenase-(decarboxylating)
MTQDRIPLAALEHGTPFADRHVGPRPAELARMLDVIGVGSLEELAQRAVPESIREGDLALDLPEPATETEALAELRALAARNRPMTQMIGLGYHGTFTPAVIRRNVLENPAWYTAYTPYQPEISQGRLEALLNFQTVVGDLTGVPVANASMLDEPTAAAEAMTLVRRAGRSKSTKFVVDADTLPQTLAVIETRAEPLGIEIVVADLSQGLEGLGLGGDFFGVLLSYPGASGVVRDHEGLIAEIHKAGAQAVVAADLLALTLLRPPGEIGADVVVGTTQRFGVPMGFGGPHAGYMAVRSGLERQLPGRLVGVSVDADGNPAYRLALQTREQHIRREKATSNICTAQVLLAVMASMYAVYHGPEGLRAIATRAHRMATVLAAGLCEGGVDVVHGEFFDTVRASVPGRADEVVAAARELGVNLWRADADTVSIACDETTTRAHLALVWRAFGVAVADVDALDSDTADGIPADLRRTTDYLTHPVFHRHRSETALLRYLRSLSDKDVALDRSMIPLGSCTMKLNATAEMEPVTWPEFADLHPFAPASDAEGLLSLIGDLEGWLAEVTGYDAVSLQPNAGSQGEFAGLLAIRAYHRANGDFERDVCLIPSSAHGTNAASAVMAGMRVVVVKCDERGNVDLGDLKDKVLAHAERLAAIMITYPSTHGVYEDTVREVCGLVHDAGGQVYVDGANLNALIGLARYGKFGSDVSHLNLHKTFCIPHGGGGPGVGPIGVRSHLAPYLPNHPLQPGAGPETGVGPISGAPWGSASILPISWAYVRMMGADGLRRATMTAVAAANYVARRLDEHYPVLYTGEGGFVAHECILDLRPLTKATGVTVDDVAKRLADYGLHAPTMSFPVAGTLMVEPTESEDLAEIDRFVDAMIAIRAEIDKVGSGDWPADDNPLRNAPHTAASVTGEWAHPYGRDVAVFPAGTSAPKIWPPVRRIDGAKGDRNLVCSCPPISAFGS
>CP029607.1|AXX32769.1|6520095_6521286_+|major-facilitator-superfamily-MFS_1
MQAVAISGAAGQGLLLTLLPLLAVSITTDPAAVSLVNVVGQLPWLLFSLFAGVLIDRARRTAVLGWSFAVLAVSALALAAIGERGGLPLLLAVAFVVTSAQVLGDGASGALVPEVVGPDRLASANARLMVIEQGVVRFVVPPLAGFAVGVGTGYAAWGALVCALLALAMMRGTASAPATPSGQNPVRDIAEGLKYLVGTRLLLAISVAVALGSFASSAEFGIFVLYAMQEIGVDEFGYGVLLACTSAGWVAMSFFVDAIVRRLGYSWSMRLAQVAMVLSAVALALAPRSPAFVGVVMFLNTALVLIWNVCSQSSRQRFTPRRLLGRVLTGHRALAWGLNPLGALAGGLLAAQAGLRSVYWMAAVVQVGALAVAWFALSPKAFREAEDAAAARAVAV
>CP029607.1|AXX32768.1|6519123_6520023_-|putative-transcriptional-regulator
MRLRFAVSPIWETVAGLRLLARAHAPHPHAEWLGWATGKLAALPDDRSVLSALVARADIPEFLIPTPGNRMVGFDAELEALTWTTTPERVTGALGAQAGLLAAPDAVPRLQERLRAVHDAVIRPVWAQVEGVLQGDLERRGQRLLDAGPPAVLGELHPDVTFESLRLVVSGRAITPGERDLVLLPSAFVWPGTHLRDSPLRLGLHYPARGFGSVWQRSCRATGDGLDRLLGGTRAALLRALERPVSVSELAGALGVTAGAVSQHLGVLRAAGLAVSRREGREVVSLRTALGVALLRGEV
>CP029607.1|AXX32767.1|6518919_6519120_+|hypothetical-protein
MIDRMTGELRGTPTSATTSLVAPARFTPPELVPPVLRTTTTTTQLPCPRGSLTRDFRGGHLCAHVV
>CP029607.1|AXX32777.1|6529356_6529563_-|hypothetical-protein
MSTRTEAEIGHAKRRAALPTAPCSVVWSKGHAYVLEGFRARWVGVDDRGRPQALTGAELQRRGWSRTR
>CP029607.1|AXX32778.1|6529978_6530395_+|Anti-sigma-F-factor-antagonist-(spoIIAA-2),-Anti-sigma-B-factor-antagonist-RsbV
MSVHDPEVVTTDGSGTGAVESGPAEHIDISAERVADGVTVVRVTGEVDMLTAPRLRSEVIERITTGGTLVLDLGGVGFLGSAGLAVLVEAAQRSTREQAAFRVVAVERAVLRPLAATGLGEVFSVHPSVAEALGGDRG
>CP029607.1|AXX32779.1|6530345_6531143_-|Serine-phosphatase-RsbU,-regulator-of-sigma-subunit
MTDQLADRHWRAEFPAEPARLSALRQRVDRWLAGLGVEQDDRYDLLMAVNEAVSNSIEHAYPPGSPGSVRVEATVEPDGRVRVVVADDGRWRVPPPGLSSRGRGLLLMRESVDEVLLDRSPGGTTVVLVLSGRHSPGTTRLAVGAHQEVVVRERAGWVEVVVRGDVPVRAGPAVRRAILTAARGGAVPVVVDLRELGDRADGLVRSLRAVASAAAEAGTRVVVRAPEGGSAHRALVASGVDQVVDLVGHASPGHRPAPRPPTGER
>CP029607.1|AXX32780.1|6531301_6531739_+|Serine-protein-kinase-RsbW
MSHTEPHSGELDNALSGVELRIAADPTQLSVVRAVAADIAMRQDFDLDSIEDLKLAVDEACSTLISLASKGAVLSARFVVADGDVQVSTQVVSERAAPPDRDSFGWRVLSALVDSVTTWVAPKSGEESYEVHIDLVKRSLGTVDA
>CP029607.1|AXX32781.1|6531735_6532542_+|RNA-polymerase-sigma-factor-SigB
MTAAEGGATKAASGKSSSQGDYDHLAPLFTRLAQTPASDPARERLRDELVTEHLPVARHIARRFGHRGEPHDDLVQVATVGLINAVDRFDPERGSDFLSFAVPTIMGEVRKYFRDSSWSVRMPRRLKELHLAINAGSARLSQELGRAPTPSELAQHLGLSREEVHEGLAAGNAYHSASLDDLLVADDSSISLGSTLGEEDPELEAIEQRESLHPLLEKLPERERRIVVMRFFGNMTQTQIAQKVGISQMHVSRLLAKTLRQLRDGLEQ
>CP029607.1|AXX32782.1|6532726_6533026_+|WhiB-type-transcriptional-regulator
MTSTARLPKPVTDVWDWQKDGLCRGRDSAVFFHPDNERGSARASRENRAKELCARCPVLAQCREHALAVQEPYGVWGGMGEDERRRIISATRRRVSAVA
>CP029607.1|AXX32783.1|6533189_6534056_-|Mobile-element-protein
MGTVTGDTPCCRLAATHHPVARRRRYPTDLTDAQWAVIDPLLPDPPWFTGQGGRPEKHCRRLVVDAILYTVDNGIKWRALPADFPPWNTVYQRFAAWELAGASQRLLDILRDRVRLKTGRAVAPSAGVIDSQSLRAAPTVGRDSRGWDAAKKVQGRKRHIVVDTMGLLIAVLATPASTHDKRAARSLLRRVRDRAGTRFSLVWADTGYHGAFPDWAHSTLGLAIEVVSRPRKTLFQVLPRRWVVERTLAWITGHRRCARDYERLPRHHEAVVRWAMIRTTIRRLTPQT
>CP029607.1|AXX32784.1|6534200_6534830_-|membrane-protein
MLALVLVASPGVWRYARHTITIAHEGGHALIALLTGRRLQGIKLNSDTSGVTVSRGRPSGPGVVAMYFAGYVTPPLLGLGAAWLVTEGHVRQLLWATVVLLAAMLIMIRNVFGVFSVILTGGVMFVVSFYGTDDLKSGFALFVAWFLLLGGVRPVGELQSRRMRGKAPQSDADQLARITRVPGLVWVLLFAAVAIGSLFYGGQLLFPEF
>CP029607.1|AXX32785.1|6535014_6535896_+|putative-oxidoreductase
MDEGTSFAILDRFAEAGGTFLDTANNYVSWTEEGTGDESEAVLGRWLAARGNRDSVVLGTKVGARPAASGPGQAGTGYEGLSAGVVEAGIEGSLRRLGTDRVDVYYSHVEDRSVDLAETLGAFAGLVARGSVREIACSNHATWRIERARAVSGANGWPAYAAAQLRFSYLRPRPGYRLPESGHVLMTGELLDFARSEGDFALVAYSALQFGQYAGRPLREENRHVGNERRLAVLGEVADELGLTRNQVVLGWVMAQGVVPVVGVSSVAQVDEALGAADLVLPEEVLARLDAAA
>CP029607.1|AXX32786.1|6536000_6536738_-|hypothetical-protein
MTHSTTTGTASGRVKVAGLQPAQVLTALLAVLLLAAGVVGFVRTGFGDFAGDRHAEVFGFHVNPLHNTVHLATGVLGLLMASGSALSRLYGWIVLLAYGAVTAWGLMITGVLSVNPVSGLGNPLAINNADNGLHAGLALAGLVIAILPARRKIVVDEPAYEPEAHHDDPVRGNRFDQPTLHHPAPEREVPKPRVEAMDPTVDASKATTGKVDPVAGDTRPVQTRGGDTRPTRTQPVDAPGARPTR

Crispr_ID: CP029607_7

• CRISPR_ID: CP029607_7
• CRISPR_location: 6963017-6963123
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP029607_7

Consensus_repeat	Method
GCCGCCGGGGCCTTGGGGGCCTGC	CRISPRCasFinder

spacers of CP029607_7

>7.1|6963041|59|CP029607|CRISPRCasFinder
GGGGCCTGCGCGGCCGGAGCCGGAGCGGCCTGCGCGGCCGGAGCCGGGGCGACCGGGGT

CRISPR arrays and Neighbor proteins around CP029607_7

CRISPR arrays

The CRISPR arrays of CP029607_7

>merge|CP029607|7|6963017-6963123|CRISPRCasFinder
GCGGCCGGAGCCGCCGGGGCCTTGGGGGCCTGCGCGGCCGGAGCCGGAGCGGCCTGCGCGGCCGGAGCCGGGGCGACCGGGGTCGCCGCCGGGGCCTGGGGGCCTGC

>CP029607|7|6|6963017-6963123|CRISPRCasFinder
GCGGCCGGAGCCGCCGGGGCCTTG	GGGGCCTGCGCGGCCGGAGCCGGAGCGGCCTGCGCGGCCGGAGCCGGGGCGACCGGGGT
CGCCGCCGGGGCCTGGGGGCCTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP029607.1|AXX33146.1|6953170_6954052_-|Riboflavin-kinase	unknown	unknown	gnl|CDD|235536
CP029607.1|AXX33152.1|6959505_6959955_-|Ribosome-binding-factor-A	unknown	unknown	gnl|CDD|234787
CP029607.1|AXX33157.1|6964936_6965461_-|hypothetical-protein	unknown	unknown	gnl|CDD|234627
CP029607.1|AXX33153.1|6959974_6960271_-|YlxP-like-protein	unknown	unknown	gnl|CDD|377364
CP029607.1|AXX33164.1|6970111_6971200_+|hypothetical-protein	unknown	unknown	gnl|CDD|237605
CP029607.1|AXX33162.1|6968742_6969531_-|3-oxoacyl-[acyl-carrier-protein]-reductase	unknown	unknown	gnl|CDD|237189
CP029607.1|AXX33150.1|6957095_6958397_-|putative-DNA-damage-inducible-protein-F	unknown	unknown	gnl|CDD|240541
CP029607.1|AXX33158.1|6965616_6966054_+|hypothetical-protein	unknown	unknown	gnl|CDD|237019
CP029607.1|AXX33149.1|6955684_6957004_-|Major-facilitator-superfamily-permease	unknown	unknown	gnl|CDD|349949
CP029607.1|AXX33161.1|6967639_6968641_-|Cysteine-desulfurase	unknown	unknown	gnl|CDD|223594
CP029607.1|AXX33147.1|6954326_6954527_-|hypothetical-protein	unknown	unknown	unknown
CP029607.1|AXX33148.1|6954712_6955612_-|tRNA-pseudouridine-synthase-B	unknown	unknown	gnl|CDD|235113
CP029607.1|AXX33145.1|6952590_6953070_-|putative-DNA-binding-protein	unknown	unknown	gnl|CDD|238045
CP029607.1|AXX33155.1|6963207_6963393_+|Flagellar-hook-length-control-protein-FliK	unknown	unknown	unknown
CP029607.1|AXX33163.1|6969579_6969987_+|Uncharacterized-protein	unknown	unknown	gnl|CDD|376651
CP029607.1|AXX33160.1|6966684_6967545_-|hypothetical-protein	unknown	unknown	gnl|CDD|223021
CP029607.1|AXX33151.1|6958484_6959495_-|3'-to-5'-oligoribonuclease-A	unknown	unknown	gnl|CDD|223691
CP029607.1|AXX33154.1|6960369_6962904_-|Translation-initiation-factor-2	unknown	unknown	gnl|CDD|235401
CP029607.1|AXX33156.1|6963926_6964940_-|Transcription-termination-protein-NusA	unknown	unknown	gnl|CDD|237061
CP029607.1|AXX33159.1|6966050_6966491_+|hypothetical-protein	unknown	unknown	gnl|CDD|373114

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP029607.1|AXX33146.1|6953170_6954052_-|Riboflavin-kinase	gnl|CDD|235536	PRK05627, PRK05627, bifunctional riboflavin kinase/FAD synthetase.	1.99703e-147
CP029607.1|AXX33152.1|6959505_6959955_-|Ribosome-binding-factor-A	gnl|CDD|234787	PRK00521, rbfA, 30S ribosome-binding factor RbfA.	1.49603e-43
CP029607.1|AXX33157.1|6964936_6965461_-|hypothetical-protein	gnl|CDD|234627	PRK00092, PRK00092, ribosome maturation protein RimP; Reviewed.	5.97389e-45
CP029607.1|AXX33153.1|6959974_6960271_-|YlxP-like-protein	gnl|CDD|377364	pfam04456, DUF503, Protein of unknown function (DUF503). Family of hypothetical bacterial proteins.	2.05692e-33
CP029607.1|AXX33164.1|6970111_6971200_+|hypothetical-protein	gnl|CDD|237605	PRK14086, dnaA, chromosomal replication initiator protein DnaA.	2.61905e-05
CP029607.1|AXX33162.1|6968742_6969531_-|3-oxoacyl-[acyl-carrier-protein]-reductase	gnl|CDD|237189	PRK12748, PRK12748, 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional.	1.43394e-49
CP029607.1|AXX33150.1|6957095_6958397_-|putative-DNA-damage-inducible-protein-F	gnl|CDD|240541	cd13136, MATE_DinF_like, DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.1384e-102
CP029607.1|AXX33149.1|6955684_6957004_-|Major-facilitator-superfamily-permease	gnl|CDD|349949	cd06174, MFS, Major Facilitator Superfamily. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.	2.61106e-24
CP029607.1|AXX33161.1|6967639_6968641_-|Cysteine-desulfurase	gnl|CDD|223594	COG0520, csdA, Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones].	1.28985e-30
CP029607.1|AXX33158.1|6965616_6966054_+|hypothetical-protein	gnl|CDD|237019	PRK11907, PRK11907, bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase.	0.000224073
CP029607.1|AXX33145.1|6952590_6953070_-|putative-DNA-binding-protein	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	0.000207021
CP029607.1|AXX33148.1|6954712_6955612_-|tRNA-pseudouridine-synthase-B	gnl|CDD|235113	PRK03287, truB, tRNA pseudouridine synthase B; Provisional.	1.13725e-164
CP029607.1|AXX33163.1|6969579_6969987_+|Uncharacterized-protein	gnl|CDD|376651	pfam01894, UPF0047, Uncharacterized protein family UPF0047. This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.	1.65601e-30
CP029607.1|AXX33160.1|6966684_6967545_-|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	0.000687667
CP029607.1|AXX33151.1|6958484_6959495_-|3'-to-5'-oligoribonuclease-A	gnl|CDD|223691	COG0618, COG0618, Exopolyphosphatase-related proteins [General function prediction only].	1.52814e-50
CP029607.1|AXX33154.1|6960369_6962904_-|Translation-initiation-factor-2	gnl|CDD|235401	PRK05306, infB, translation initiation factor IF-2; Validated.	0
CP029607.1|AXX33156.1|6963926_6964940_-|Transcription-termination-protein-NusA	gnl|CDD|237061	PRK12327, nusA, transcription elongation factor NusA; Provisional.	0
CP029607.1|AXX33159.1|6966050_6966491_+|hypothetical-protein	gnl|CDD|373114	pfam14530, DUF4439, Domain of unknown function (DUF4439). This domain has a ferritin-like fold.	2.86621e-31

Protein sequences

>CP029607.1|AXX33154.1|6960369_6962904_-|Translation-initiation-factor-2
MVPPRPQSPKPQGPRGPRPGNNPFGVGGGAPAPRPQAPRPQGGPGGGERGDRGSKPGDPRPGGPRPAGPRPGGSAGSGGPRPNPGNMPPRPNPGMMPGRSAAPRPGGGGGGRPGGGPGGGGRGPGGGGGGGGFRGGGGGGGGGGFRGGGGGGGGGGFRPGGGGPGGGGGGGGFRPGGGGGAPAGGGGGGFRGRPGGGGPGGRGGTAGAFGRPGGPARRGRKSKRQKRQEYMDNMQAPSVGGVRLPKGSGETIRLPRGASLTDFADKINANPASLVQVLFHLGEMVTATQSVSDEILELLGSEMNYVVQVVSPEEEDRELLETFDITYGEDAGGEDDLAIRPPVVTVMGHVDHGKTRLLDTIRKTKVAEGEAGGITQHIGAYQVQTELEGNPRLITFIDTPGHEAFTAMRARGANSTDIAVIVVAADDGVMPQTVEAINHAQAANAPIVVAVNKIDKEGANPAKIRQQLTEYGLVAEEYGGDTMFVDISAKQGVNIDGLLEAILLTADASLDLRANPGMEAQGVAIEAHLDRGRGPVATVLVQRGTLRVGDSIVAGDAYGRVRRMVDEHGDDVTEAYPSRPVLVIGLTSVPRAGDTFLVVEEDRVARQIAERRQARTRNALNAARRKRVSLEDLDAALKETSQLTLIIKGDNSGTVEALEDALMKIEVGDDVELRVIHRGVGGITEGDINLAVAGSAIVLGFNVRAEGKATELANREGVDVRYYTVIYQAIDEIEQALKGMLKPEYEEVQLGRAEVREVFKSSKVGTIAGCLVLSGEIRRNARARLLRDNNVIQESLPISSLRRFKDDATEVREGYECGLTLGNYGDLKIGDVIETFEMREKPRA
>CP029607.1|AXX33153.1|6959974_6960271_-|YlxP-like-protein
MYVGALELDLLLGDVHSLKQKRSVVRPVVAELKRKFEVSASEAGHLDLHRRALIGVAVVAADAEHVRDVLAACERLVAGRPELELLSARHRLVGPEDV
>CP029607.1|AXX33152.1|6959505_6959955_-|Ribosome-binding-factor-A
MADQARARKLAKRISQIVASALEHQVKDPRLARVTITDTKVTGDLHDATVYYTVLGEKLDSEPDLAGAAAALEKAKGVLRSMVGQQTGVRFTPTLTFVTDTVPDEARKMDELLAKARELDAEVARIASDAKPAGEADPYKAAREVEESD
>CP029607.1|AXX33151.1|6958484_6959495_-|3'-to-5'-oligoribonuclease-A
MDDLNAAVAAAARVLERARDVTLLGHVNPDADALGSALALGLALHRRGATVRVSFSEPAEVPRSLAGLDVAGLLVPPSQVPERPEVLVALDSGSVGRLGHLGGRIATAEHVVVIDHHVSNPGYGTINIVDDRAEATAVVVLRVLDELGVELDEPVARCVYAGLVTDTRSFRHATESTHLVAARLIAAGVDGEALARSLMDSHPFGYLAMLAGVLGRARLEPSAAGGLGLVHAVVTLEDAAGLRSEEVESVVDLVRTTTEAEVAAVLKELRPDRWSGSLRAVSRVDVREVAQLLGGGGHRLAAGFTAAGTAEEVLERLRQALGTVVAAAGEPRDLRR
>CP029607.1|AXX33150.1|6957095_6958397_-|putative-DNA-damage-inducible-protein-F
MVERVPARRVVGLAAPALVVLAAEPLYLLVDTAVVGHLGALPLAGLALGGVLFTQVATQLTFLSYGTTARTARLFGAGRRAEAVAEGVQATWLALAVGALVIVLGQLLAGPAARLLVGDEVVAAEAVSWLRIALFGAPMVLVTMAGNGWMRGVQDTRRPLRYVLFGNAVSAVLCPLLVHTAGWGLEGSAVANVVAQLLSAGLFLRALVVERVPLRPVPALMRAQLGMGRDLVLRSLAFQACFLSAASVAARTSVAAVGAHQVVLQLWTFLALVLDSLAIAAQSIVGAFLGADRREDAKGFARQVTGYGLVFGSCLGVLFAALSGVIPGLFTGDAGVLGEIPNAWWFFVALQPIAGVVFALDGVLLGAGDAAFLRTATLLSAAAGFLPLIWLSLAFGWGLSGIWTGLSAFMALRLVAVVLRTRSGRWAVPGAAV
>CP029607.1|AXX33149.1|6955684_6957004_-|Major-facilitator-superfamily-permease
MPVDRATRRAWLIWSTAVIVYVAALFHRTSLGVASLEAGERFAVGSAALGAFTVLQIGLYAAMQIPTGLLVDRFGARRVLVAAALVMGLGQTLFALAHSYPLGLAARAVLGVGDALTWVSVLRLAAAHFPPRRFTVVMSLSSALGAIGNLAATVPLTLMLDGIGWTTTFLVAGVATAAYAAVVALKVRETPDGVVQPEPERVRLSVVGRKVAEAWHVPGTRLGFWVHFTTMSTPMLLSLLWGYPYLVEAQGMPAASASAVLSVMVVVGLVSGPVLGGVIARSPEWRMPLVGGYLAVAVGVWAVLLGWPGGVLPQPLLPVAFGLLALGGPASSVAFALVRDYNPLHRVSTATGVANVGGFAAITVMALVIGVLLDVVSFLPPAQAYRVALLSVAAVLVLGTWRTVVWWRRARAAVFAAEDRGEEVPVQIRRGRFDMRLAA
>CP029607.1|AXX33148.1|6954712_6955612_-|tRNA-pseudouridine-synthase-B
MPASPRPAVPPGLVVVDKPDGMTSHDVVAKVRRILGTRKVGHAGTLDPMATGVLVLGVERATKLLGHLALDSKAYLSTIRLGASTTTDDAEGEVLSSADSTAVPEDAIRAGVAKLTGAIQQVPSAVSAVKVDGKRAYARVRAGEEVELPPRPVTVHRFDVLSIRREADATELDVMVECSSGTYVRALARDLGVDLGVGGHLAALRRTRVGPFDLRVAKTLEQLADEPGLSLDLDAAVSAAFPRREITPSEVVALSHGQRLRAGGVEGTYGVFGPDGHAVALAKDEGPLAKPVVVLTPAG
>CP029607.1|AXX33147.1|6954326_6954527_-|hypothetical-protein
MPALRAAAPGGPRPPFPAARVPRFPRPAPLPAVPAAAPRFRPRPGALRLPQPRSRRSPPAQATPLG
>CP029607.1|AXX33146.1|6953170_6954052_-|Riboflavin-kinase
MLTVGSFDGVHRGHQALIRRAVETAAERGVPSVVMTFDPHPAEVVRPGSHPAKLTDLRRRAELVEALGVDVFCVVPFTPELSRMPADEFVHEVLVDRLHVAAVVVGRNFTFGSRAAGNVGLLRELGQRFGFVTEGADLLSDDGVTYSSTYTRACIDAGDVAAAATALGRPHRLEGVVVRGDGRGRDLGFPTANMSLPESAAVPADGVYACWFVRDGHPTMRAAVSVGTNPTFSGKERRVEAYVLDFDDDLYGQTVALDFVARLRGMVKFDGVEALVEQMHRDVADARVQLPDA
>CP029607.1|AXX33145.1|6952590_6953070_-|putative-DNA-binding-protein
MEDHKIVQRNLALQREWYGEPLGDRVRRLVVAFNVSQAQLAEVLGISAPMLSQVMSGRRAKIGNPAVLARMIMLERKVLTPDVATGAPEALQRALDEVRDSKPTVSRDSLPVNGADDETALLPYLRRIADRRELFQAADVLGEDFPALADLLRRAGRAR
>CP029607.1|AXX33155.1|6963207_6963393_+|Flagellar-hook-length-control-protein-FliK
MGMEGRGASEPPWGADGACGLGAEGRAPEDGFLPSPLACASRSRRATGASTVLDADFTYSP
>CP029607.1|AXX33156.1|6963926_6964940_-|Transcription-termination-protein-NusA
MNVDIAALRAIERDKDIPFDTVLEAIETALLTAYKHTDGHHPHSRVEIDRKSGAVRVLAQDLGPDGVVTEEWDDTPEGFGRIAATTARQVILQRLRDAEHERTFGEFSAKEGEIIGGVVQRDARANARGMVVVQVGDTEGVLPPAEQVPGEEYKHGARIKCYVVGVSRSARGPQITLSRTHPNLVRRLFALEVPEIADGTVEIPAVAREAGHRSKIAVRTSVPGVNAKGACIGPMGARVRNVMSELAGEKIDIIDHSDDPATFVGNALSPAKVVSVRVLDERAKTARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRSDAEAVQKDSAASGSAE
>CP029607.1|AXX33157.1|6964936_6965461_-|hypothetical-protein
MSSPPRGELAAQLTPVVREAVEAIGYDLELLDVNQAGRRRLVKVVVDGDEGIGLDEVAQASRAVSAALDANEHLIAGPYTLEVTSPGADRPLTRPRHWLRARLRLVKVKQPEQVEWFGRVGDCDDTGVVLLVKGELRRVEYSAIERAVVEVEFKQPPVEELALLGDRGSKEESE
>CP029607.1|AXX33158.1|6965616_6966054_+|hypothetical-protein
MIGLSRRAVLLAAASAPLVVACTSTPPAPPPPDPLAALADAALEDAALATAVDAQETAAARTEHAARLRAEVERATPSTPSSSAAPSTTSSAPQAPAGATREQLAAALQAAQKQAADLLPSLPAHRAGLVGAVAAGCASLVEALG
>CP029607.1|AXX33159.1|6966050_6966491_+|hypothetical-protein
MSDQASADAVQVGLGAEHAAVWTYGLVSAFLPKAQEAVVAEGANAHRARRDTTERWLRDAGQQPKPAAAAYLPPEGVQDAASSIAALVAVEADCCAAWRGVLERTDDNALRTTALTALTESAVRGTRWRRAAGLTPVSIALPGVPE
>CP029607.1|AXX33160.1|6966684_6967545_-|hypothetical-protein
MGPPPPQDQGQPQPVPPTPQQTPSGTLTFEPVPGHQGPPHPGGPPPYGGYDQGFRPPPPPPRGAPGGQARSHPATAPGLSAVPFQRRTAVVRIIGLVGIAVVSGLVWMMFQSGEGPKSSSGSPTPSSASQVPAGEFEFTPSTQAPAPRRDAECASHAYGQAKDFFTKTPCEELIRALYTTTAAAGGAKVHTSVAVVRMKSAADATALMELTNRDGTGNVNDLVKDGAVKVDGITTLGGGGYASTLSDRDVVIVESDTAKADNTGAGHIDLMRRISADALRLAAGLG
>CP029607.1|AXX33161.1|6967639_6968641_-|Cysteine-desulfurase
MRTAFGETFDVPPGYLNTASVGVPSTSTARAVSEAVARWARGADAPPVFDEPVAVARAAFGRIVGAPAERVAIGATVSQLVALVAASLPEGARVLVAKGDFTSLTFPFAARGHTVTEVPLDDLPARAADHDLVAVSVVQSADGRLADLAALRAAGVPVLLDATQAAGWLPLELGWADWVVGTGYKWLLSPRGTAWLACSEAALARTAPLVANWYAGDDPWTTVYDLPLRLAADARRLDLSPVWHAHVGAAVALPWFASLDRAAVHAHTTGLADGLRAGLGLPPAGSAIVSLDVPPEPLLAAGVAASTRAGRVRLAFHLYSTRDDVDRVLRALA
>CP029607.1|AXX33162.1|6968742_6969531_-|3-oxoacyl-[acyl-carrier-protein]-reductase
MIENVPHTAIVTGANQGIGAAIATALAARGVQVLAAYFRFTPLPDPSLPDRYAADRGADATAVVRAIEAAGGRVLAVEADLADPQAPARLFDTAERELGPVDVLVNNASAWVQDTFLAVGLDQFGRTTAPVSAETFDAQFAVDARAGALLIAEFARRHLARGADWGRIVGLTSGGPGGFPSEVTYGAAKAALDNYTMAAAVELAPHGVTANCVKPPATDTGWVNDAVRASTRIAEPHEVADVVAFLCSEEAKLVTGNVVTLR
>CP029607.1|AXX33163.1|6969579_6969987_+|Uncharacterized-protein
MLSEEIEIRTGSDEVVLDLTAHCERFLAKTSGDGLLHVWVPHATAGLAVLETGAGSDTDLLAALRDLLPADGRWRHRHGTPGHGRDHVLPALVPPHATVPVLGGVMALGTWQSVCLVDTNVDNPVRKVRFSFLAG
>CP029607.1|AXX33164.1|6970111_6971200_+|hypothetical-protein
MRAVTYPGDGQSGWGGQAGQPHQGGWGQDGVGGSTPQPGQPQQHYPDHSFGAPQPGYGDQQPYPQPGYGDQQGYPQPAYGDQQGFPQQGFGSYGGLGVFSGGEEPPRRSTRGKVWLAVGAVALLLVGGGATAYVLTRPEDGKTTVAASSSQAAPSSSAASSPAPTSPSAQAATCAAVTSGWNCLPVTDLAYSYDVPKSWAPQKGSSPVTNLDARLTGLSMFGVYTCEGRSYNRGNAGGTLISNTDLAGVAKDVADKVARYFYSSAPELDVKLTDPKEVTVPNVGGGQPIPAVQVDATITAGGNACIASKGMVRVLAARGERATHVFMANGDLAGGPDSAPASPTEGDLQAMIDSVRPLAVGG

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP029607_6	6.1|6529221|23|CP029607|CRISPRCasFinder	6529221-6529243	23	NZ_CP054615	Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence	47461-47483	2	0.913
CP029607_6	6.1|6529221|23|CP029607|CRISPRCasFinder	6529221-6529243	23	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	407629-407651	3	0.87
CP029607_5	5.10|6451003|30|CP029607|CRISPRCasFinder	6451003-6451032	30	NZ_CP010864	Marinovum algicola DG 898 plasmid pMaD9, complete sequence	80476-80505	4	0.867
CP029607_1	1.1|1940743|28|CP029607|CRISPRCasFinder	1940743-1940770	28	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	938435-938462	5	0.821
CP029607_1	1.1|1940743|28|CP029607|CRISPRCasFinder	1940743-1940770	28	NZ_CP022191	Yangia pacifica strain YSBP01 plasmid unnamed1, complete sequence	163312-163339	6	0.786
CP029607_1	1.1|1940743|28|CP029607|CRISPRCasFinder	1940743-1940770	28	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	987809-987836	6	0.786
CP029607_1	1.1|1940743|28|CP029607|CRISPRCasFinder	1940743-1940770	28	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	825320-825347	6	0.786
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NZ_CP011274	Planctomyces sp. SH-PL62 plasmid pPL62-1, complete sequence	21732-21765	6	0.824
CP029607_1	1.1|1940743|28|CP029607|CRISPRCasFinder	1940743-1940770	28	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	1029051-1029078	7	0.75
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NC_013856	Azospirillum sp. B510 plasmid pAB510b, complete sequence	435239-435272	7	0.794
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NZ_CP039640	Azospirillum sp. TSH100 plasmid p1, complete sequence	24069-24102	8	0.765
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NC_016588	Azospirillum lipoferum 4B plasmid AZO_p6, complete sequence	196495-196528	8	0.765
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	KR053197	Gordonia phage GRU3, complete genome	6456-6489	8	0.765
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NZ_CP013104	Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence	888718-888751	8	0.765
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	441692-441725	8	0.765
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	1371374-1371407	8	0.765
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	NZ_LN832562	Paracoccus aminovorans isolate JCM7685 plasmid IV, complete sequence	161801-161834	8	0.765
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	ASHF01000034	Streptomyces sp. GBA 94-10 plasmid pGBA1, complete sequence, whole genome shotgun sequence	194947-194980	8	0.765
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	MK977698	Microbacterium phage Busephilis, complete genome	7243-7276	8	0.765
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	MK875798	Microbacterium phage Piperis, complete genome	7328-7361	8	0.765
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	MT818415	Microbacterium phage Scumberland, complete genome	7546-7579	8	0.765
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	MN062719	Microbacterium phage PiperSansNom, complete genome	7669-7702	8	0.765
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	MN444877	Microbacterium phage Antares, complete genome	7568-7601	8	0.765
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	NZ_CP016082	Streptomyces sp. SAT1 plasmid unnamed2, complete sequence	64428-64461	8	0.765
CP029607_5	5.10|6451003|30|CP029607|CRISPRCasFinder	6451003-6451032	30	NZ_CP049030	Fluviibacterium aquatile strain SC52 plasmid pSC52_2, complete sequence	317283-317312	8	0.733
CP029607_5	5.10|6451003|30|CP029607|CRISPRCasFinder	6451003-6451032	30	NC_006569	Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence	62115-62144	8	0.733
CP029607_5	5.10|6451003|30|CP029607|CRISPRCasFinder	6451003-6451032	30	NC_015741	Roseobacter litoralis Och 149 plasmid pRLO149_94, complete sequence	58356-58385	8	0.733
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	MT639653	Arthrobacter phage Elezi, complete genome	16275-16308	9	0.735
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	MT889366	Arthrobacter phage London, complete genome	16275-16308	9	0.735
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NZ_CP030864	Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence	112008-112041	9	0.735
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NZ_CP032054	Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence	1020264-1020297	9	0.735
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NZ_CP016560	Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence	676504-676537	9	0.735
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	MN369753	Gordonia phage Sukkupi, complete genome	8002-8035	9	0.735
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	MK376960	Gordonia phage BiPauneto, complete genome	8111-8144	9	0.735
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	MN369766	Gordonia phage Yndexa, complete genome	8002-8035	9	0.735
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NZ_CP043499	Rhizobium grahamii strain BG7 plasmid unnamed, complete sequence	1224218-1224251	10	0.706
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	NZ_CP024427	Paracoccus yeei strain TT13 plasmid pTT13-5, complete sequence	33748-33781	10	0.706
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	NZ_CP020443	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed3, complete sequence	20051-20084	10	0.706
CP029607_4	4.2|5489506|34|CP029607|PILER-CR	5489506-5489539	34	NZ_CP044079	Paracoccus yeei strain FDAARGOS_643 plasmid unnamed2, complete sequence	344443-344476	10	0.706
CP029607_4	4.1|5489443|34|CP029607|PILER-CR	5489443-5489476	34	NC_012811	Methylorubrum extorquens AM1 megaplasmid, complete sequence	564208-564241	11	0.676

1. spacer 6.1|6529221|23|CP029607|CRISPRCasFinder matches to NZ_CP054615 (Azospirillum oryzae strain KACC 14407 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.913

gcctcgggccggggcgtcaggtg	CRISPR spacer
gcctcgggccggggcgtcatctg	Protospacer
*******************  **

2. spacer 6.1|6529221|23|CP029607|CRISPRCasFinder matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 3, identity: 0.87

gcctcgggccggggcgtcaggtg	CRISPR spacer
tcctcggcccggggcgtcaggtc	Protospacer
 ****** ************** 

3. spacer 5.10|6451003|30|CP029607|CRISPRCasFinder matches to NZ_CP010864 (Marinovum algicola DG 898 plasmid pMaD9, complete sequence) position: , mismatch: 4, identity: 0.867

tgtgtaggtgagcgggccgttcactcaccc-	CRISPR spacer
ggtataggtgatcgggccgttcac-cacccg	Protospacer
 **.******* ************ ***** 

4. spacer 1.1|1940743|28|CP029607|CRISPRCasFinder matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 5, identity: 0.821

attcggg----ggcacccccggcatcgggggc	CRISPR spacer
----gggatctggcaccctcggcatcgggggc	Protospacer
    ***    *******.*************

5. spacer 1.1|1940743|28|CP029607|CRISPRCasFinder matches to NZ_CP022191 (Yangia pacifica strain YSBP01 plasmid unnamed1, complete sequence) position: , mismatch: 6, identity: 0.786

attcgggggcacccccggcatcgggggc	CRISPR spacer
tttcgggggcacccccggcaccgccgag	Protospacer
 *******************.**  *. 

6. spacer 1.1|1940743|28|CP029607|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 6, identity: 0.786

attcgggggcacccccggcatcgggggc	CRISPR spacer
tggcgggggcacctccggcatcggttgc	Protospacer
   **********.**********  **

7. spacer 1.1|1940743|28|CP029607|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 6, identity: 0.786

attcgggggcacccccggcatcgggggc	CRISPR spacer
tggcgggggcacctccggcatcggttgc	Protospacer
   **********.**********  **

8. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NZ_CP011274 (Planctomyces sp. SH-PL62 plasmid pPL62-1, complete sequence) position: , mismatch: 6, identity: 0.824

tcggcgacgacgcggccgaaggcgtcgcgctcga---	CRISPR spacer
tcggcgacgacgcggccgagggcttcg---gcgaacc	Protospacer
*******************.*** ***    ***   

9. spacer 1.1|1940743|28|CP029607|CRISPRCasFinder matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 7, identity: 0.75

attcgggggcacccccggcatcgggggc	CRISPR spacer
caccgggggcacccgcggcatcggacgg	Protospacer
  .*********** *********. * 

10. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NC_013856 (Azospirillum sp. B510 plasmid pAB510b, complete sequence) position: , mismatch: 7, identity: 0.794

tcggcgacgacgcggccgaaggcgtcgcgctcga---	CRISPR spacer
tcggcgacgaagctgccgaaggcggc---ctcggcca	Protospacer
********** ** ********** *   ****.   

11. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NZ_CP039640 (Azospirillum sp. TSH100 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.765

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
atggcgacggcgcggcggaaggcgtcggcgtcgc	Protospacer
 .*******.****** **********   *** 

12. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NC_016588 (Azospirillum lipoferum 4B plasmid AZO_p6, complete sequence) position: , mismatch: 8, identity: 0.765

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
atggcgacggcgcggcggaaggcgtcggcgtcgc	Protospacer
 .*******.****** **********   *** 

13. spacer 4.1|5489443|34|CP029607|PILER-CR matches to KR053197 (Gordonia phage GRU3, complete genome) position: , mismatch: 8, identity: 0.765

tcggcgacgacgcggccgaaggcgtc-gcgctcga	CRISPR spacer
gcgtcgacgacgcggccgagggcgtcagtgagtg-	Protospacer
 ** ***************.****** *.*  .* 

14. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NZ_CP013104 (Paraburkholderia caribensis strain MWAP64 plasmid 1, complete sequence) position: , mismatch: 8, identity: 0.765

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
ccgggcgctgcgcgggcgaagccgtcgcgctcga	Protospacer
.***  .* .***** ***** ************

15. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 8, identity: 0.765

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
tcggcgacgacgcggccgacgacgcgctgcacgg	Protospacer
******************* *.**.  .** **.

16. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 8, identity: 0.765

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
tcggcgacgacgcggccgacgacgcgctgcacgg	Protospacer
******************* *.**.  .** **.

17. spacer 4.2|5489506|34|CP029607|PILER-CR matches to NZ_LN832562 (Paracoccus aminovorans isolate JCM7685 plasmid IV, complete sequence) position: , mismatch: 8, identity: 0.765

agctcggtgatcaggcccgcggcgtcggtgcggt	CRISPR spacer
acttcggcgatcaggcccgcggcgtcgatcagca	Protospacer
* .****.*******************.*  *  

18. spacer 4.2|5489506|34|CP029607|PILER-CR matches to ASHF01000034 (Streptomyces sp. GBA 94-10 plasmid pGBA1, complete sequence, whole genome shotgun sequence) position: , mismatch: 8, identity: 0.765

agctcggtgatcaggcccgcggcgtcggtgcggt	CRISPR spacer
gcctcggtgatcaggccagcgacgtcggcgacct	Protospacer
. *************** ***.******.*   *

19. spacer 4.2|5489506|34|CP029607|PILER-CR matches to MK977698 (Microbacterium phage Busephilis, complete genome) position: , mismatch: 8, identity: 0.765

agctcggtgatcaggcccgcggcgtcggtgcggt-	CRISPR spacer
ctctcggggctcaggcccgcggcgtc-atgccgcg	Protospacer
  ***** * **************** .*** *. 

20. spacer 4.2|5489506|34|CP029607|PILER-CR matches to MK875798 (Microbacterium phage Piperis, complete genome) position: , mismatch: 8, identity: 0.765

agctcggtgatcaggcccgcggcgtcggtgcggt-	CRISPR spacer
ctctcggggctcaggcccgcggcgtc-atgccgcg	Protospacer
  ***** * **************** .*** *. 

21. spacer 4.2|5489506|34|CP029607|PILER-CR matches to MT818415 (Microbacterium phage Scumberland, complete genome) position: , mismatch: 8, identity: 0.765

agctcggtgatcaggcccgcggcgtcggtgcggt-	CRISPR spacer
ctctcggggctcaggcccgcggcgtc-atgccgcg	Protospacer
  ***** * **************** .*** *. 

22. spacer 4.2|5489506|34|CP029607|PILER-CR matches to MN062719 (Microbacterium phage PiperSansNom, complete genome) position: , mismatch: 8, identity: 0.765

agctcggtgatcaggcccgcggcgtcggtgcggt-	CRISPR spacer
ctctcggggctcaggcccgcggcgtc-atgccgcg	Protospacer
  ***** * **************** .*** *. 

23. spacer 4.2|5489506|34|CP029607|PILER-CR matches to MN444877 (Microbacterium phage Antares, complete genome) position: , mismatch: 8, identity: 0.765

agctcggtgatcaggcccgcggcgtcggtgcggt-	CRISPR spacer
ctctcggggctcaggcccgcggcgtc-atgccgcg	Protospacer
  ***** * **************** .*** *. 

24. spacer 4.2|5489506|34|CP029607|PILER-CR matches to NZ_CP016082 (Streptomyces sp. SAT1 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.765

agctcggtgatcaggcccgcggcgtcggtgcggt	CRISPR spacer
agaccggcgatcaggcccgccgcgtcggcgtcgc	Protospacer
** .***.************ *******.*. *.

25. spacer 5.10|6451003|30|CP029607|CRISPRCasFinder matches to NZ_CP049030 (Fluviibacterium aquatile strain SC52 plasmid pSC52_2, complete sequence) position: , mismatch: 8, identity: 0.733

tgtgtaggtgagcgggccgttcactcaccc	CRISPR spacer
tgtgtaggtgatcgggccgttaacgatgga	Protospacer
*********** ********* **      

26. spacer 5.10|6451003|30|CP029607|CRISPRCasFinder matches to NC_006569 (Ruegeria pomeroyi DSS-3 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.733

tgtgtaggtgagcgggccgttcactcaccc	CRISPR spacer
ggtataggtgatcgggccgttcacgatcga	Protospacer
 **.******* ************   *  

27. spacer 5.10|6451003|30|CP029607|CRISPRCasFinder matches to NC_015741 (Roseobacter litoralis Och 149 plasmid pRLO149_94, complete sequence) position: , mismatch: 8, identity: 0.733

tgtgtaggtgagcgggccgttcactcaccc	CRISPR spacer
ggtataggtgatcgggccgttcacgacgcg	Protospacer
 **.******* ************    * 

28. spacer 4.1|5489443|34|CP029607|PILER-CR matches to MT639653 (Arthrobacter phage Elezi, complete genome) position: , mismatch: 9, identity: 0.735

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
gcggcgtcggcgcggccgaaggcgtcgataatgt	Protospacer
 ***** **.*****************    .* 

29. spacer 4.1|5489443|34|CP029607|PILER-CR matches to MT889366 (Arthrobacter phage London, complete genome) position: , mismatch: 9, identity: 0.735

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
gcggcgtcggcgcggccgaaggcgtcgataatgt	Protospacer
 ***** **.*****************    .* 

30. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NZ_CP030864 (Streptomyces globosus strain LZH-48 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.735

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
cctacgtacacgcggccgaaggcgtcggggtcgc	Protospacer
.* .**   ****************** * *** 

31. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NZ_CP032054 (Streptomyces clavuligerus strain F1D-5 plasmid pSCL1, complete sequence) position: , mismatch: 9, identity: 0.735

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
gcggcgacgtcgcggtcgaaggcgtgtttctgca	Protospacer
 ******** *****.*********  . **  *

32. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NZ_CP016560 (Streptomyces clavuligerus strain F613-1 plasmid pSCL4, complete sequence) position: , mismatch: 9, identity: 0.735

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
gcggcgacgtcgcggtcgaaggcgtgtttctgca	Protospacer
 ******** *****.*********  . **  *

33. spacer 4.1|5489443|34|CP029607|PILER-CR matches to MN369753 (Gordonia phage Sukkupi, complete genome) position: , mismatch: 9, identity: 0.735

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
tcggcgacgtcgcggccgcaggcgaactgaacaa	Protospacer
********* ******** *****   .*  *.*

34. spacer 4.1|5489443|34|CP029607|PILER-CR matches to MK376960 (Gordonia phage BiPauneto, complete genome) position: , mismatch: 9, identity: 0.735

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
tcggcgacgtcgcggccgcaggcgaactgaacaa	Protospacer
********* ******** *****   .*  *.*

35. spacer 4.1|5489443|34|CP029607|PILER-CR matches to MN369766 (Gordonia phage Yndexa, complete genome) position: , mismatch: 9, identity: 0.735

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
tcggcgacgtcgcggccgcaggcgaactgaacaa	Protospacer
********* ******** *****   .*  *.*

36. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NZ_CP043499 (Rhizobium grahamii strain BG7 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.706

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
tcggagacgacgccgccgaaggcgcggaagatgc	Protospacer
**** ******** **********. * .  .* 

37. spacer 4.2|5489506|34|CP029607|PILER-CR matches to NZ_CP024427 (Paracoccus yeei strain TT13 plasmid pTT13-5, complete sequence) position: , mismatch: 10, identity: 0.706

agctcggtgatcaggcccgcggcgtcggtgcggt	CRISPR spacer
gcgtcggtgatcaggcacgcggcggcgccggcgg	Protospacer
.  ************* ******* ** .*  * 

38. spacer 4.2|5489506|34|CP029607|PILER-CR matches to NZ_CP020443 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed3, complete sequence) position: , mismatch: 10, identity: 0.706

agctcggtgatcaggcccgcggcgtcggtgcggt	CRISPR spacer
gcgtcggtgatcaggcacgcggcggcgccggcgg	Protospacer
.  ************* ******* ** .*  * 

39. spacer 4.2|5489506|34|CP029607|PILER-CR matches to NZ_CP044079 (Paracoccus yeei strain FDAARGOS_643 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.706

agctcggtgatcaggcccgcggcgtcggtgcggt	CRISPR spacer
gcgtcggtgatcaggcacgcggcggcgccggcgg	Protospacer
.  ************* ******* ** .*  * 

40. spacer 4.1|5489443|34|CP029607|PILER-CR matches to NC_012811 (Methylorubrum extorquens AM1 megaplasmid, complete sequence) position: , mismatch: 11, identity: 0.676

tcggcgacgacgcggccgaaggcgtcgcgctcga	CRISPR spacer
gatgcgacgaggcggccgaaggcggcggcgatgc	Protospacer
   ******* ************* **    .* 

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	6972638 : 7023370	44	Neodiprion_abietis_NPV(25.0%)	tRNA,protease	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>CP029607|6972638:7023370|DBSCAN-SWA
GTCAGCCGCGCGCGACGGCCAGCACGTGCTGCACGGCCTCGTCGACCGGCACCTCGACGCGCTCGCCGGAGCGGCGGTCCTTGACCTCGACCAGACCGCTGGCCAGGCCGCGGCCGACCACGAGGATCGTGGGCACGCCCACCAGCTCGGCGTCGGCGAACTTCACGCCGGGGCTGGCCTTGCGGTCGTCCAGCAGCACGCTCAGGCCCGCCGAGGACAGCTCGCCCGCGAGCTTCTCGCCGCCCTCCAGGAGGGTGGCGTCCTTGCCCGCGACGACCACGTGCACGTCGGCGGGGGCGACGTTGCGCGGCCAGATCAGGCCGCGGTCGTCGTGGCTCTGCTCGGCGATCGCGGCGACCAGGCGGGACACGCCGATGCCGTAGGAGCCCATGGTGATGCGCACGGGCTTGCCGTCCGGGCCGAGGGCGTCGAGCGAGAACGCGTCGGCGTACTTGCGGCCGAGCTGGAAGATGTGGCCGATCTCGATGCCGCGCGCGGCCACCAGGACGCCCTTGCCGTCGGGCGACGGGTCGCCCTCGCGGACCTCGGCGACGTCGATCGTGCCGTCCGGGGTGAAGTCGCGACCGCAGAGCAGGTCCACGACGTGGTGCTCGTGCTGGTCGGCGCCGGTCACCCAGGCGGTGCCCTCGACGACGCGCGGGTCGACCAGGTAGCGGACCTCGTTCGCCAGCAGCGCGCCGGGACCGATGTAGCCCTTGACGAGGAAGGGGTGGGCCTTGAAGTCGGCCTCGTCCAGCATGGCGACCTCGGCGGGCTCGACGGCCGCCTCCAGGCGCTTGAGGTCGACCTCGCGGTCGCCGGGGAGGCCGATCGCCAGCAGCTCCCAGTCGGAACCGGGGACGCGGGTCTTGACCAGCACGTTCTTCAGGGTGTCGGCGGCGGTGAACTCGCGGCCGAGGCCCGCGTTGTTGAAGAACTCGACCAGGGTGTCGATGGTCGGGGTCGCGGGCGTGCTGTGCACCTGCGCCTCGGGGCGGCCCTCGACCGGCTGCGCGGGGGGCGCGGGGGTGGTGACGGCCTCGACGTTGGCCGCGTAGTCGGACTCGGTGCTGCGGACGAAGGTGTCCTCGCCGTTCGGGGCGACCGCCAGGAACTCCTCGGACGCCGAGCCGCCCATCGCGCCGGAGGTCGCGGACACGATGACGTAGTCCATGCCGAGCCGGTCGAAGATCTTGATGTAGGCGGCGCGGTGGCGCTGGTACGCCTCGGCCAGGCCATCGTCGGTGAGGTCGAAGGAGTACGAGTCCTTCATGACGAACTCGCGACCGCGCAGGATGCCCGCGCGGGGGCGCGCCTCGTCGCGGTACTTGGTCTGGATCTGGTAGAGCGCGACCGGGTAGTCCTTGTACGAGCTGTACTCGCCCTTCACGGTGAGCGCGAACAGCTCCTCGTGGGTGGGGCCGAGCAGGTAGTCGGCGCCCTTGCGGTCCTTGAGGCGGAAGATGTTGGGGCCGTACTCGGTCCACCGGTTGGTGGCCTCGTAGGGCTCCTTGGGGAGCAGCGCGGGGAACTGGATCTCCTGCGCGCCGATCGCGTCCATCTCCTCGCGCACGACCCGCTCGATGTTGCGCAGCACCCTCAGGCCCAGCGGCAGCCACGAGTAGCCGCCCGGCGCGACGCGCCGCACGTAGCCCGCGCGGACCAGCAGCTTGTGGCTCGGGACTTCGGCGTCGGCCGGGTCCTCGCGCAGCGTGCGCAGGAACAGCGACGACATCCTCGTGATCACGGTTGGGACTCCTCGTGGGGCTGGTGGTCCGGAAAAGCCTAGTGAACGGGGTGACGGGGGTTCCAGCCGGTTACCCCGGCGCGGGGTGGGCGGGGGTTCGCGGTTGCCACCCGGACGGGTGGTGTTCGGGGGCGGCGGCGGTCGGGGGCCGGTCGGGGGCCGGGAATTGTCGGGGGTCGTCGTTAGCGTGCCGGGCATGGGGCTGAGCTACGGGATGACGACGGTGGACGCGGCGGACCCTCGGGGGTTGGCGGCGTTCTGGGCGGGCGCGCTGGAGACGGACGCGGTCCAGGAGTACGGGGACGACGGGGACCTGGTGATGCTGACGGCGGAGGGCGGGGTGCGGTTGGGGTTCCAGCGGGTGGCGGAGCCGACGCCGGGGAAGAACCGGGTGCACCTGGACTTCGGGGCGGCGGACCTGGCGGCGGAGGTCGAGCGGTTGACCGGGTTGGGGGCGGTGCTGGTGGCGGAGCGGTCGATGCCGGGGGTGGAGTGGGTGGTGCTGGCCGATCCGGCGGGGAACCAGTTCTGCGTGTCGAAGGCGGGGTGAGGGGGGCGGGTGAGGTGAGGGGGTGGTCGACGGCGCGCGGCGGCGGTTGACGGCGGTTGCCTGCGCTTGCCTGCGCTTGGTGACCGGCCGGTGGCGCGGTCGGCTCCGGCCGGGGTATGGCGTGGCCCCGGTGCGGGGTGTCCGGCGGCGCGGGTGTCCGGCGGCGCAGGTGTCCGGCGGCGCGGGTGTCCGGGGTGTCCGGGGTGTCCGGGGTAACTGCGTGGAGTGGCGGGGACGGGTGGTTCCGGTGGGTAGGCTCGCCGGTCGTGCTCGTGCTGCTGCCTCCGTCCGAGACCAAGGCGACCGGTGGGTCCGGCGCTCCCCTCGACCTGGACGCGCTGTCCCACCGGGAGCTGAACCCGGTGCGCGACAAGCTCGTCACCGCGCTGGTCGACCTGGCCGCCGACGTGCCCGCGTCGCTGGCGGCCCTCGGCCTGTCGGAGCGGCAGGCCGGGGAGGTGGGGCGGAACGCCGAGCTGCGCGCGTCGGCCACGACGCCCGCGCTGCGGCGGTACACCGGCGTGCTCTACGACGCGCTGGACGTCCCGTCGCTGACGAAGGCCGAGCGCGACCGCGCGTTCGCCAGGATCGGCGTGGTGTCGGCGCTGTTCGGCCTGGTCGGGGGTGGTGACGCGATCCCGGCGTACCGCCTGTCCGGCGGCAGCGCGCTGCCCGCGACCGGCCCGCTCGGCGCGCTGTGGCGCCCCGCGCTGACCCCGGTCCTGGCGGAGGCCGACGAGTTCGTCGTGGACCTGCGCTCGGGCCCGTACGCGTCCCTCGCGAAGGCCCCCGCCGCCGTGGTGGTCCGGGTGGTCAGCGACGACGGTTCGGGGCGGCGCAAGGCGGTGAGCCACTTCAACAAGGCCCACAAGGGCCTGCTGGCACGCGCCCTGGTCCGCTCGCGCACCGAGCCGTCGACGGTGGCCGGGCTGGTGAAGGTCGCGGCGAGCGCCGGACTCACGCTGGAGGAGACCGGGGCGAAGACCCTGGACCTGGTGATCACCGGCAACCCCGCGGACAAGCCCGCGGCCTGACCGCGGCACCCCGGAACTCAGGCACCCCGGAGCTCGGGGGGTCGGAACTCGAGGGCCTGGAACTCGGAGCCCGGCAACCGGCCTCCTCCCCGCCCCGCGCTCTCCCGCCCGGTACCCCCGCACTCTTGCCGGGCGTTCAGCGCGCCCTCGTCCCCTCCCCACCGCTATTCCGGGGTCCCCAGCCCACGTCCGGTGGTGTCCAGCCTGCTCCCCGTGGTGTTCGGTGGGTTCCGGCGGTGTTCGGCGGTGTTCGGCGGGCAGGGTGCGCACCGGCCCCGTTCGGTCGCCGCCGCTCGGGTGAACGGAGTTGCACGCTTCACGTGGAATGCCCGGATTCTGGGAACGGCGGGGGTGTCCGGGCCGACATCCGTCAGGGAGAGAAGTCGATCCGGGGGGTGTGCGTTGACCGGTGCTGATCCGGTGTGGCAGAGCACGAGTCTGCTGGGGAGGGTGCGCGAACCCGCGCGCGCCGACCTGCTCGCGCTGGGGACGCGGGTGCCGTACGGGCCGGACAAGGAGGTGATCGTCCAGGACGCGCGCGACACGCACGTGCTGCTGCTGCTCAGCGGCATGGTGAAGGTGCAGGCCGTGGACGAGGACGGTGAGCGGGCGCTGCTGGACATCCGGATCGCCGGTGACGTCGTCGGCGAGATGGCCGCGCTGAGCGGCAGGCCGCGGTCGGCCACGGTGCGCACGTGCGGGGACGTCGTGGCCCGCGCGATCACCCGCGCCGACTTCCAGGCGCTGCTGCTGCGCCGCCCCGAGGTGGCGATGGAGCTGGTGCTGGTGGTCGGCGAGCGGTTGCGCTGGTCGATCGACCGCCGCCGCGACTTCCTGTCCTGCCCGGCGCCGGTGCGGGTGGCCCGCGTGCTCGTGGAGCTGGTGCAGACCTACGGCAGGCAGGACAAGGACGCGTGGCGGCTGGGCATCCCGCTCACCAAGGTCGAGCTGGCCTCGATCGCGGGCATGAAACCGCGCACGGCGGAGAAGGCGTTCAGCGACCTGCGGCACGCGGGCGTGGTCGTCAGCAACCTGCGCCGCGACGTCCTGGTGCCCGACCTGCGGGCGCTGCGCCGCTACGCCGGATCCTGAGAAACCGCGCGTTCGGGTGGAATCCCGCGCTTCGGCGAAACGAACCGGCCGTGCGGCACGACCTGCACGCCGGGGGATGACAACGGTTGCAGCGAGTTGCGGATACGACGCATTAGGGGTGGATGGTGCTGATGTCATGGTCACCGAGCACGACCCAGCCGGAGCAACCGGTGTGGCCGCACGACAGCCTGCTGTCGCGGCTGCGCGACCAGGCGCGCGACGAGCTGCTGGCGATGGGCACGGTGGTGCGGTACGCGCCGAACCGGGACGTGATCGTGCAGGACGCCCGCGACACGCACGCGCTGCTGCTGCTCGACGGCGTGGTGAAGGTGCAGACCACGGACGAGACCGGCGACACGGCGCTGCTGGCGATCAAGGCGGCCGGTGACTTCGTCGGCGAGATGGCGGCGCTGGACCGCAAGCCGAGGTCGGCGAGCGTGATCACGTGCGGCGAGGTGACCGCGCGGATGATCAGCAGCAGCGAGCTGATGGGCTTCCTGCACCGCCGCAACGAGGTCTTCGTCGAGATGATCGGCATGGTGAACGAGCGGCTGCGGTGGGCGATCGAGCGCAGGCGGGACTTCCTCGCGCGGGCGGCCGACGAGCGGTTGGCGAAGGTGCTCGCGGAGCTGGTGCGCACGCACGGCCGCGAGGAGCCCGGCGGGTGGACGCTCGGGTTCCCGCTGACCAAGGTGGAGCTGGCGTCGATCGCGGGCATGAAGCCGCGCACGGCGGAGAAGGCGTTCAGCGACCTGCGCAAGGCCGGGGTCGTGGTGAGCCACCTGCGCCGGGACGTGCTGGTGCCCGACCTGGACGCGCTGCGCGCCTACGCCCAGCGCCCGCCGCGCTGAGTGGCGGGACGGGGAGTGGCGGGGCGGGGAGGGGCAGGACGGGGAGGGGCGGGCTGAGCATCGGGCCGGTCGGAGGGCGGGCTGAGGTCGGGCCAGGCTGAGCATCAGGCCGGTCGGAGGGCGGGCTGAGGTCGGGCCGGGCCGAGGTCGGGCCAGGCTGAGCATCGGGCCGGTCGGAGGCCGGGCTGAGGTCGGGCTGAGGTCGGGCTGAGGTCGGGCTGAGGTCGGGCTGAGGTCGGGCTGAGGTCGGGGCGGGCTGAGGTCGGGGCGGGCTGAGGTCGGGGCGGTCGGAAAAGCGGTTGCCCCGCCGGGTGCGGGCGGGGCATGGTGGGTGAGCGCAGCGACTCGCGGGCCGGAGAGCCCGGAGCGGATTCGGGGAGGAGGTGTCGACATGGCCATGACACCTGTCCTGGACGCGGCACCGGCCCGTCCACCCACCCCGGCGCTCCACAGGGTCTGACGCGGTCGCGCGGCCCGGCGTCGGGGTGATCACCCACTTCCCGCTGGGAGCCCCGCTGTGCGCGAGCACGCGATCACCACGAACGCACTGCACGAACTCAAGATCAACTTCAATCACGGCGGTCGGGTCGACGACGCCGCCTGTGCCGATACCCGCTACGGCGGTACCGATGGTGTCGACACCGATGCCGATGCCGATGCCGACGACTACGCAGGTCACGCCGATGCCGACGGCTACGACGCCGACGGTCACGACGAGGGTGGCGGCGACGACAGCGACGCCGACCCGTACGGCCGCTGGTCCGACTACGAGCTGGACGACTACGGCCCCCGCGAGGTCAGGACTCGGGTCCGGGTCGTGCGGGACGACGAGGAGAACGTCCGGCGCGGCAGGCTCACCGAGGAGGCCAAGAAGCGGCTCGGCGAGTCGCGGCAGCTCACCGGGCCCGAGGACGGCGACCGGTGGTCCACCTGGGGCAGCGCCGACCAGGGGCCCGCGCCGCACCCGGCGTGGCTGGTCACCGACCTCGGGGCGGTCGACCGGGAGCTCGGGCTGATCAAGTCCGGCAAGGAGGCGGACGTCTCGCTGCTGGAGCGCGCCACGCCCGAGCGGTCCTGCCTGCTGGCCGCGAAGCGGTACCGGGACAACGACCACCGGCTGTTCCACCGGGACGCGGGCTACCTGGAGGGCCGTCGGGAGCGGCGGAGCCGGGAGGCCCGCGCGATGTCCCGGCGCAGCGCGTTCGGGCGGAACCTGATCGCCGAGCGGTGGGCGGTGGCCGAGTTCGCGGCGCTCGGCGCGCTGTGGCAGCGCGGCGTGCCGGTGCCCTACCCGGTGCAGCGCGACGGCACCGAGGTGCTGATGGAGTTCATCGGCGACGGCGCCCAGGCCGCGCCCCGGCTCGCCCAGACCAGGCCCGAGCCGGACGCGCTGGTGGACCTGTGGCGGCAGCTCGGGTCGGCGCTGACGGGGATGGCCGCCGCCGGGTACGCGCACGGCGACCTGTCGCCGTACAACCTGGTGGTGCACGACGACCGGCTCGTGGTGATCGACCTGCCGCAGCTGGTCGACCTGGTCGCCAACCCGCGCGGGGCCGAGTTCCTGGCGCGCGACGTGCGGGTGGTGGCCGACTGGTTCACCGCGCGCGGCCTGCCCGCCGAGCTGGCCGACCCGGCCGAGCTGACCGCCGACCTCCTCCGGGAGGCCGGACTGGGGTGAGACGGGCGCTCGCCGGGCGAGAGGGCGCGCGTCCTCTCGCCCAGCGGGCGCGGCACCCAGCGGACGCGGCACCCAGCGAACGCAGCGCGCGGCGCACGTGCAGTGAGAGCACTGGTCACCCACCGCGAACACGTGCGGTGGGATCGCGATTTCGTTGTGTCACCAATGCTTTCGCCCGATCGACGCCGCTCGGTGACCGCCTCGCCACCCCGCGCCGCAACGGTGCGCGACGGCGGCGTCCGCCGGGCGTCACCGCGCGTTCGCGGCGCCGCGAACACCGGCTGCCGTCCGTGACCGCCGCGCGAACGCGCCCCGTGACGAACCCTCGGGTCCCGGTGGCGCACGGGCCGTTCGACCTGGGCCCCTCCCCCGTCTCAACAGGCCGCTCCGGAACCGGATCCTCTTGCGCCCCAGCGGTTTCCGCGTCCGGAGAGCGGACGCCCGCGCACACCCGCGAGCGATCGCGCCACCGTCAGGTGGAACCCGGCCACGTCCGGGTGCCGCGCGGGGCGCCCCCTCAGGTGGCGTGGAAGACCGCCGAACCCCTCGACGTCCGCCCGCAGCCCGCCGAGCCGGCCGCCCCCACAACCTTCCCGACGTCCACGCAGGTCAGAGCCTCGCGCCCGAAACTAGTCCGAGTGGCCGCGACCCAATGGATGATGATCAGCTAGACTGGTCAACGCACCGCACGAGGGCGCTACATTCCAGCGCCCCGAGGTCACCACTCAGGACCACCCGGTGCTCCACCCAACCGTCGGCGCTACGAAGCGCCGGGCCCGTCCGCGCGATCGCGCCTGCCCACGAGTGCAGAGCAATCCCCGTGACGTGCCGTGTCCCGGAGGTATGTTTTGCCACCCGTGTCCCAGAGCCGTTCCGAGCGCCCGCAGTCCTCTCGCAGGCCCCGCAAGCGCTCCGGCCAGGGCAACCGCCGTCCGCAGCACGTGGACGCGCCCCTCGCTTCCACCGTTCCCGACCACGTCGAGAGCACCCTCCCCGAAGGCCCGCTGCCCTCGTTCAGCGAGCTGGGCCTGGCCGACGAGCTGGTCCGCGCGCTCGCCACGGCCGGGATCACCGAGCCGTTCCCCATCCAGGCCGCGACCCTGCCCGACTCGCTCGCGGGTCGCGACCTGCTCGGCCGGGGCCAGACCGGCTCCGGCAAGACCCTCGCGTTCGGCCTGGCGCTGCTGTCCAGGCTGGCCGGTGGCCGCGCCAAGCCGCACATGCCGCGCGCGCTGGTGCTGGTCCCCACCCGTGAGCTGGCCATGCAGGTCGAGGAGGCGCTGTCGCCCTTCGCCCGCGCCCTCGGCCTGTGGTGCCGCACCGTCGTGGGCGGCACGTCCTTCCCGCGCCAGATCGACGCGCTGCGCAGGGGCGTCGACCTGCTGATCGCCACGCCCGGTCGGCTCTCCGACCACGTGCGCCAGGGCACCGCGGACCTGTCCGAGGTCATGTTCACCGCCCTGGACGAGGCCGACCAGATGGCCGACATGGGCTTCATGCCGCAGGTGCGGGCCATCCTGGACCTGACCCCCGAGAACGGGCAGCGGCTGCTGTTCTCCGCGACGCTCGACGGCGACGTGGACAAGCTGGTCCGCCAGTACCTGCACGACCCGGTCGTGCACTCGGTCGCGCCGCCCACCGGCAGCGTCACCACCATGGAGCACCACCTGCTGTTCGTGTCCGCCGAGGACAAGCAGTCGGTCGTGACCGAGGTGGCCGCGCGCGAGGGCCGCACGATCATGTTCGTGCGCACCAAGCACCACGTGGACCGGCTGGCCAAGAAGCTGCGGTCGATGGGCGTGCACGCCGGCGCCCTGCACGGCGGCAAGGCGCAGAGCGCGCGCACCCGCGTGCTCGGCCAGTTCCGCGAGGGCACGACCCCGGTCCTGATCGCCACGGACGTCGCCGCGCGCGGCATCCACGTGGACGACGTCAGCCTGGTCGTGCACGTGGACCCGCCCGCCGACCCGAAGGACTACCTGCACCGCGCCGGTCGCACGGCGCGCGCCGGGCAGTCGGGCACGGTCGTCACGCTGGTCACGCACGACCAGCGGCGCGCCGTCCAGGGCCTGACCTCGCGCGCGGGCATCCGCCCGGAGTCGACCAAGGTCCGCCCCGGCGACGACGAGCTGATCCGCATCACCGGCGCCCGCGAGCCCAGCGGCGTTCCCGTGGTGGAGCCCGAGGTGCAGCCGCGCGGTCGTCGTGGTGGCGCGGGCGGCGGCGCGGGCGCCCGTCGTGGCGGCGGCGGGTTCTTCCGCGGCGGTCGCGAGGGTGGCCGTGGCGAGGGTGGCGGCCGTGACCGCGACCGCGCGGGCGGCCGTCCCCGGCGCAGCGCGGCCCCGCAGCACTGAAGCAGCACTGAAGCAGCACTGACGAGTGACGCGTGGCGCCGATAGCGGGCGCTGACGCGGAACGGCGAGAGCCCCGGTCCCCGGTGGGACCGGGGCTCTCGCGTTGCTCGGGGGCGGGTGGAGTGGCCGGAATCCCGGTGTCGCTGCGTGATGTGGCTGCCGGGCGTGCGCCGGGGGGCCGGTTCCCGAGCGTGACGCCCACGCCCGGAGCCCGGTGGCCGAGCGTGATCCGGCCCGGTGGCCGAGCGTGGTGCGACGGCCGGGGTGCGCGGTGGCCGAGCGTGACGTCGCGCGGGAAGCCCGCGCGCGGGCTTCCCGCGCGGTGCGGTCACACCTGCTCGGGCAGTTCCCCCGCCAGGCCCGCGACCGGGCCGACGACGATGATCGCCGGCGGGCGGACGTGGTGCGCCGCAACGGCTTCCGCCAGACCGTCCAGAGTGGACCTCACGATCCGCTGGGCGTCCGTGCTGCCGTTCTCGACGACGGTCACCGGGGTGTCACCGGGGCGGCCCTCGCGGAGGGCAGCGGCGAACGCGGCGGCGCGCTCGACGCCCATCAGGATCACCACGGTGCCGCGCAGCCTCGCCAGCGCGCCCCAGTCGACCAGGGAGCGCTCGTCGTCCGGCGCGACGTGGCCGGACACCACCACGACCTCGTGCGCCACACCCCGGTGCGTCACCGGGACGCCCGCGAGGGCGGGAACGCCGAACGCGCTGGTCACGCCCGGCACGACGGTGACCGGCACGCCCGCCTCGGCGCAGGCGATCAGCTCCTCGAAGCCGCGCCCGAACACGTACGGGTCGCCGCCCTTGAGCCGGACCACGAACTTCCCGGCCTTGGCGTTGTCCACGAGCGTCCGGTTGATGAACTCCTGCGCGGCGGCCCGCCCGTACGGGATCTTCGCGGCGTCGACCACCTCCACGTGCGGCGGCAGCTCGTCCAGCAGCCACACCGGGCCGAGGCGGTCCGCGACGACCACGTCGGCCCTGGCCAGCAGGCGCCTGCCGCGCACGGTGATCAGGTCGGGGTCGCCGGGGCCGCCGCCGACCAGGGCCACGCCCGCGGGCTGGTCGTGCTGGTCGGCGAGGGTGCCGTCGCGCAGCGCGGACAGCACGCCGTCGCGCACGCGCGCCGAGCGGTTGTGGTCGCCGCTGGCCAGGACGCCGACGAGCAGGCCGTCGTGGTTGCCGGAGGCGGGGGTGACGGCGGTGCCGAGCGCGCCGACGTCGGCGCGCACGCAGAACACGCGGCGGGCCTCGGCGTCGGCGGTGATCCGGGCGTTCACCTCGGGGTCGGAGGTGCAGGCGAGCACGTACCACGCGCCGTCCAGGTCGCCGTCGGCGTAGCGCCGGGCGTGCCAGGTGACCGCCCCGGAGTCGACCACGCCCTGGACGGTGGGGGTGACCTCGGGCGAGACGAGTTCGACGCGGGCGCCGGACGAGACCAGGCGCGGCAGGCGGCGCTGGGCGACGGACCCGCCGCCCACCACCACCACGCGCTTGCCCGCCAGGTCCAGGCCCACCAGGTAGTGCTGTTCTCCGTGCATGGCGAGAAGCATCCCCGGACGACGGGCCCGCGCCCAAGAGGGGTGTCCCACATCACGGGAAGCGGGTGTCGGAGTGTGAGCGGACGGCGGGAGGGCGCGCGGCGACAGGGCGCAAGGGCCGCGCGGCGCGGGCGGAAGGGCACCGGGCGGGGCGGGGCGAACGGACCGGGACCGGGAGGCGCGGGCGGGCGCGGGCACGGGGAACGCGCGGACCGACCGAGGGCTGACCGGTCCGCGCGCCCGCCCGCGCCCGGTCGACCGGAGGACGTCGGTCACCGGGCGTGGGGCGCGCCGCGCGGGCGCGCCCCCGGCGGTCATCCGATCTGCGCGCTCAGCACGCTGTAGTAGGCCGCGACCCTGGCGTACACGCCGGGGTAGTTGGGCAGCGCGCAGCCGTTGCCCCACGAGGTGGCGCCGATCAGCTTGCCGCCGGCCACGAGCGGGCCGCCCGAGTCGCCCTGGCAGGTGTCCTTGCCACCGGCCGGGACGCCCGCGCACACCATCGAGGTGTTGCTGTACTGCGAGTACGCCGTCTTGCAGGTCGCGTCCGAGGTGACCGGGACGGTGACCTTCAGCAGGTAGCGGGACGTGGAGCAGCCGGAGCAGGTGGCGCCCCAGCCGTACGCGACAGCGTTGGTGCCCGCCGCGTAGAGGGCCGTGTCGGACGGGGTGGCCAGCGGCAGGTAGGTGCCGCTGACGCTGGTGCCCAGGGTCAGCACGGCCACGTCGTAGCCGCTGGTCGCGGTGCGGTAGCTCGGGTGCGACCAGATGCCGGAGACGGTGGCCACCGTGCCCGCGGTGCTCTGCTTGTCCTCGCGGCCGATCACCACGCGGGTGCTGGACGCCGAGCGGCCCGCGACGCAGTGCGCGGCGGTGACGACCTTGTTGGCCTTCACCAGGGTGCCGCCGCAGAACTGGGAGCCGGAGGAGGAGGCCAGGTACACCGTCCAGGGGGCCTCGCTGATCGAGGCCCTGGTGCCGCCCACGATGAACGGGGTGACGTCGGACGCCGAGGACACCGGGGTCGTCATCAGGCCGATCGCGGCGGCAGCCACGCCCAGGCCGATGAACTTCGCCAGGCGACGCAGGGTTTTCGCCATCGGAGTTCCTTTCCGTGCAGGAGTGAGCACTCACTGCAACGCACCCGACGGCCTCCCGGCAACCTCCTTCAGCAGGACTGAGGGGGCTTCACAATTGACCAGTGACTCCGGTCACACGAACGACATCGGCGTGTACCGGCCCGGCAACAACCGGTCCCGCGTCCGGCGCCACCAGCGCCACCGCGACGCCCTGCTCCGCCAGCCGCACCGCGCCGTCCGCGCGCACCGACGTGCCCGGCCGCAGCAGGTGCCTGACCTGGTCGACGCACTCCGGCGGCCCGACCACCACGGACGCGCGGCGCAGCTCGGCCTCCGCGCGCGGGGTGCGGTCGTCCGCGCCGCCCGGCCCGAGGCCGATGAGCGCCAGCCTGCCCCTGGGCAGGACGCGGGCGGCGGCGACGGTGGCCCGCGCGCCCTTGACCTTCTCGGCGGCGATCTCCACCCGGCCACCGGCGGACAGCTCGGCCGCGCCGCGCAGCGCGGCGGCCTCGGCGACGCTGGGGATGCCGATGGCCAGCTCCACCGGGTTCGGCACCGGGATGACGGCCAGCTCCTCGCCGGGGTAGCCGAGCAGGGGCGTGGTGGTGGAGCCGTGCCAGAAGCCCCAGTCCTCGACCGCGTCGACGATGCCGGGCTCCTCGGTCTTGCGGTCGAGCGTGGCGAACGCGCGCACGGCCCGCAGGTCCAGCCTGCCGTCGGCGGCGAGCTTGGCGAGCGCGCCGGAGACGTCGGTGGACGTGACGCCCGCGCTCGCGCCGATGCCGATCACGAGCGTCCTGGGGATCACCCGGACCACGTGGTCGCCCAGCTCGGTCCTGGGCACCCGGTCGTCCAGCAGCACCGTCCACGCGGCCTCGTGACCGGCGGGCAGGACGTTGTCCGGCAGCGCGGGCAGCGGGAAGCCGAGCGGGTTGGCGAGCGCGACCGGCTCGCCCGCGCGCATCGCCTCGCCGCACGCCACCGCGTCGCCCTCGGCGGTGGCGTCGAGCAGTTCGAGCAGCTCGTCCAGGGGGGACGCGGTGGGCGGGGCGGTGGTGACGGCGGTGCGGCCGAGCACGTCGGCGACCCGCTGGGCGAGCGCGTCCGCGCCGCCGAGGAGGGCGATGGCGAACGCGCCGTCGACGCACACCACGCCGGGGTCGGAGCGCTCGTCGCGCAGCAGGGGGGCCACGAGGCGGATGGCGGTCTCGCTGCCCTCGAAGAGCACGGCGCTGCCCAGCACCGGCCACATCCGGCGCAGCGCGGGCGCGACGGGGCCGTCGGGGACGACGGCGTCCGGGCCGAGGAAGGCCGCGAGCTCCTTGGCCTGCGCCCTGCCGCGCTCGGTCGACGCGAACAAGCCGATCACGCTGCCTCCTTGCCGGGGTGGAGGTGCCATCCTTCCCCGCCGGGCGCGGTGGGGTGGGGGCGGGTGGGGTGGGGCGGAGCGGGGGGAGTTGAGCGGGGAGGGCCGGTGGGGGGCGAGCGGGGGTGCACGGGACCGCGCGGCGCGGGTGGGGCAGGCCAGGCCGGGCGGGACGGCGGGCACGGGGCCCAGGCGGGGCGGGCCGGACGGGCGAGGCCCGAGCGAAGCCAGGCGGCTGGCCGAGGGCGGGTCGGGCTTGGCGGGGGGCGTCGGGCTTGGCGGGCACGTCGGGCGTGGCGGGCACGTCGGGCTTGGTGGGCGCGTCAAGGCGCGTCAGGTTTGGCGGGCGCCGAGCGGGTCGTCGTGCGGCGGTCAGGCCGGGTGCTCGGCCCACAGCACGGTGACCGGGTCCACCGCGCGCAGGTGGTCGTCCTCCAGCCTCGCGGCGGACAGCTGGGTGCCGGACACCGCGTAGCCGCCGTCGCGGAGGGCGTCGTGGGACGGCAGGACGGCGTCGAGGCGGGTCGTGGCGACGACCACGCGGCGTGCGCCCAGGCCCGCGCAGGCGCGCACCGCGCCCGGTCCCCCGCCGCCGACGAACACCGCGTCGGGGCGCGGCAGGTCGCGCGGGGCGAGTTCCACGTCGGACTCGACCACGCGCACGTCCACGTGGTGCGCCGAGGCGTTCGCGATGATCCGGACGCACTGCACCGGGTCGCGCTCCACGGCCACCACGGCCGCGCCCAGGCGCGCGCACTCCACGGCGACCGCGCCGGGACCCGCCGCCACGTCCCACACCAGCGCACCGGGCCTGGGGCCGAGCTTGGCGAGGACGAGCGCGCGGACCTCGGCGGTGGCGACCAGGCCGTCGCCCCGGTGCGAGAACTCGTCGTCCGGCAGCGCCCACCGGGAGGCGTCCGGGAGCAGCGGCTGCTCGGCGAGGCACAGCACCGGGAGCGGCTCCGGCCAGGAGCGGAGCGCGACCTCGGCGGGGTCCGCCGTGGACGGTCCGGACGGGCCGGGCACGACCAGGGTGCGCCGCCAGCCCGCGAGGCCCTTCGCCAGCGCGGCCGGGTCCGCGTTCGCGACCAGCACCGAGGAGCGGGCCAGGCACACGTTGCGGGCGTGCGCGAGGCCGTGCTCGGCGGCGTCCACCACCACGACGGCGGACCAGGTGCGGCCGGTGTCGGTCAGGAAGCGGTGCAGCGCCGGGACGTCCATGCCCTCAGCCTGTGCGCTTCGGCTTCTTCCCGCGCGCCGGGGCGGGCTTGCGCGGGGTGGTGCTGGCCTGGACGGAGACGGTCCTCTTGCGCGCCGCCGCGACCGGGGGCTTCTTCCTCGGCTCCGACGGCTCCTGCTCGGGGGAACCGGCCTGACCGGGCAACGCGTCCACGGCGAGCGCCTCCGCGACCGGCCCGGACTCGGCGGACTCGGTGATCTCGGCGGGACCGCCGGGCTCGGCCAGCGACCGCGCTACGGGCAGCTCCACGCCGTCCGCGCCGGACTCCTCGCGCGCCCTGGCCCAGCGCGAGCGCGCGGTCTCCTGCAGGTCGTGCACGGCCGACCAGGCGGCCTCCGAGCGCGACTCGGCGCCCGGCGCCCGCGCCGCCCGCCACTTCGAGGCGCGGGGCTGGCGCACCGGCTCGTCCCCGATCGGCGCGCCCCTGCGGACCGGCGCCCTGAGCGCGTCGCCGACCAGGAAC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TGCGGCGGTGTCCTTCCTCGGGTGTCCACGCCCGTGTCCGGTCCAAGCGATCGGGGGTCGAGTTCCTGACTCCCGGTTCTGACGCCGGTCACAGTGGCGGGACCGCGCCGGATTCGCACCGGCTTCCTCGCGCACCCCTCGCTACAGCCTGGGCATCGTCGCATCCCGCACGGGCTGGGCCAAGCGCGCGGACGGCGGTGTGGGTGATCTCGCAGCGCGTGGCCGCCGCTCCCCCGCCGTCACGCGCCCCCGACGGCTAGGCGGACTTGAGCGGCAGCGGGAAGGTGACCCCGGTCAGCTCCTCGGAGACCGTCCACAGCCTGCGGGCCAGCTCCGCGTCCTGCGCCGCCTTGGACCGGCCTACCAGCTTGGGCGCGCCCTTGCCCAGCGCGCCGCTCGGCCCGGAGAACGCGTTGCCGGGGACGGTGGCCAGCGCCGCGTGCAGGGTCGCCTGCGCGCCGCCCTCGTCGGTCTGGCCGACCGCCCGCACACCGGCGTTGACGAGCCGGTTCAGCGGGTTGTCCCCGCCCTGCGGGCGGAACAGGTTGGTCGCGGCGAGGCCGGGGTGGGCGCTGGTGGCCAGCACCGGGGAGCCGACGGCGGTGAGCCTGCGCTGGAGCTCGGCGCTGAACAGCAGGTTCGCGAGCTTGGACTGGCCGTAGGCGGCCATGGCGCGGTAGGGCTTGCGCTCCCAGTTCAGGTCGGCGAAGTCGATCTTCCCGGCGCGGTGCGCGCCCGACGACACGGTGACCACGCGCCCGGTGATCCTCGGCAGCAGCAGGTTCGTCAGCGCGAAGTGGCCGAGGTGGTTGGTGCCGAACTGGGACTCGAAGCCGTCGGCGGTGCGGTTGAGCGGCGGGGTCATCAGGCCGGCGTTGTTGACCAGCAGGTCGACCTGGTCGCCGAAGCCGTCGGCGAACGCCCGGACCGAGGCCAGGTCCGCCAGGTCCAACTCGCGGACCTCGGTGCTCCCCGGCATGGTCGAGGCGGCCTCCCGCCCCTTGGCGGTGCTGCGCACGGCGAGCACCACGCGCGCGCCCCTGGCCGCGAGGACGCGGGCGGTGACGCGGCCGATGCCGCTGTTGGCCCCGGTGACGACGGCGGTGCGGCCGGTCAGGTCGGGGAGGTCCGAGGCAGAGAATGTAGTCACAGGCAACAATGTAGCCACCGACAACACAATCGGCAACCGGCAGCCCGTTAACCTGGTGCCCGTGACCGTTGACGACCGCCCCTACCACCACGGGAGGCTCCGCGAGGCCCTGCTCGACGCCGCCTGGCGCAGCGTGCGGGAGCACGGCGCGGAGCAGCTCTCGCTCCGCGAGCTGGCCAGGGAGGTCGGGGTCAGCCACGCCGCGCCGCGCAGGCACTTCCCCGACCGGCAGGCCCTGCTCGACGCGCTCGCGATCGCCGGGTTCGAGCGGATGGACGTCGAGCTGCGCACCGCCGTGGCGGGCGCGGGCGTGGACTACCGGGACCGGCTGGTCGCCGCCACGCGCGCCTACTTCCGGTTCGCGGTGGACGACCCGGCGCTGCTGGAGCTGATGTACACCGGCAAGCACCGGCCGGGCGCGGACGCGGTCGTCGCCGCCGTGGCGGCCCCGCTGGGACTGCTGGAGGCGATGCTCGCCGAGGGGCGGGAGCGGGGCGAGCTGGGCGACGGGGACCCGGAGCGGATCGGCGTGCTGATGTTCGCGACCGTGCACGGGCTCGCCGCCATGGTGAAGGGCCGAATGGTCGACCGGGAGGTCGCGGGCGGGCTGGTGGACGACGCGGTGGTGCGGTTCCTCACCGGCGGCGTCCCGAGCGCGGCGGGCGCACCCGGCGCGGCGGGTGGCGCGCTGTGGACCTGCCCCCGGCCCTGAGCGCCCCGACACCGGGCGCCGCGACACCGGGCGTCCACGTTCCGGACCGCGGCGGTGGTGGTGCGAGACTCCTCCCGTGACGGAGCACACCGGGGAGTCGGTATTCGACTGGATCGACGCGCGCGCCGAGGCTCGGGCCGAGGCCGGGCTCACCCGGCGGGTGCGGCCACGCGCGGCGTCCGGCGGGGCGCTCGACCTGGCGGGCAACGACTACCTCGGGCTCGCCAGGGACAAGCGGGTCGTGGGCGCGGCAGCCGCCGCGTCGATGCGCTGGGGCGCGGGCTCGACCGGGTCGCGGCTGGTCACCGGCTCCACCGAGCTGCACACCGAGCTGGAGTACGAGCTGGCGAACTTCTGCGGCGCGCAGGCGGCGCTGGTGTTCTCCTCCGGGTACGCGGCGAACCTGGGCGCGCTGACCGCCCTGTCCGGGCCGGGCACGGCGATCGTGGCCGACCAGCACATCCACGCCTCGCTGATCGACGGCTGCAAGCTCTCGCGCGCGGACGTGGTGGTGGCCGGGCACCGCGACCTGCCGCAGGTCACGCGCGCGCTGTCCACGCGCGGCGAGCGGCGCGGGCTCGTGGTGACCGACTCGGTGTTCTCCGTGGACGGCGACACCGCGCCGCTGGCCGAGCTGGCGGCGGTCTGCCGGGAGCACGGGGCCGGGCTGGTGGTGGACGACGCGCACGGGCTGGGCGTGGTCGGCGACGGCGGGCGCGGCGCGGTGCACGCGGCGGGGCTGGCGAAGTCCCCGGACGTGGTGACGACGGTGACGCTGTCGAAGGCGCTGGGCGCGCAGGGCGGCGCGGTGCTGGGGCCGGGCCGGGTGATCCGGCACCTGGTGGACACCGCGCGCACGTTCATCTTCGACACCGGTCTCGCGCCGGGCAGCGCGGCGGCGGCGCTGGCGTCCCTGAAGGCGCTCAAGGAGGAGCCGGAGCGCCCCGAGCGGGTGCGCGAGGCGGCCCGCCGGCTGTCGGAGCGGTTGCGGGAGCGGGGTTTCCGGGCCAGCGAGCCGAGCGCGGCGGTGGTGTCGGTGCTCGCGCCGTCGCCGGAGGTCGCGGTGGCGTGGGCCGAGGCGTGCCGGGAGCGGGGCGTGCTGGTCGGGTGCTTCCGGCCGCCGTCGGTGCCGGACCAGGTGTCGCGGCTGCGGTTGACCGCGCGCGCCGACCTGTCCGAGGCGGACCTGGCGCGCGCGGTCGAGGTCATCGCCGAGGCCGGCGCATCCGCAGGTGCGGGATCCCGTCCTCGATGAACTCCTCGCCCTCGGGGGCGAACCCGAACGAGGCGTAGAAGTCCACGACGTAGGTCTGCCCGTCGAGCACCGCCTCGGCGTCGCCGATCTCGGCCATCGCCGCGACCATCAGGCGGCGGCTGAAGCCCTTGCCGCGCGCGGTCCGCGCGGTGACGACCCGGCCGACGCGGAAGACGCCGCCGGGCTCCTCCAGCAGCCGCAGGTACGCCTGCGGCTCGCCGTCCTCCTCCAGCCACAGGTGCCGGGTGCCCGGTTCGAGGTCGCGGCCGTCCAGCTCGGGGTACGGGCAGTTCTGCTCGACGACGAACACGTCGACGCGCAGCTTGAGCAGCGCGTACAGCTGGGTCGCGGTGAGGTCGGCCGCCCACTGCCTGCGCAGGGTCGCCGGGTGGTGTTGCGTCACCCTGAATTGGTAGCACGGGCGCGGTCGTTCGGGCGGTGAACGGCGATCCCGGTCACCCCGGCCGCGACGGCTCACCGGGCCGCCGCGGCGCGCGGGGTCAGAGCCGGTCGCGGTAGTGGGCGAGCCGGGTGTAGGCGCCGGGCTGGCCCGCGCGGGCGCAGCCCCGGCCGTAGGAGACGACGCCGACGAGCAGGCCGTCGGAGACCAGCGGGCCGCCGGAGTCGCCCGTGCAGGCGTCCCTGCCGCCGTCCGGGAAGCCCGCGCACAGCATCGCGTCGGCGCGGTAGCCGGCGAGCGCGGCGGCGCAGTCGTGGTCCGTGCGGATCGGCACGTCGACCTGGCGCAGCAGCGAGGACACCGGGCCGCTCTCGGCGGTGCGGCCCCAGCCGTAGGCGGTGGCGGTGCGGCCCGCGACGGCGTCGCCGACCCGGACGGGCTCGAACGCGACCGGGCCGTCGAGCTGGAGCACGGCCAGGTCGTCGCCGCGTCCCACGTCGGTGAACGCCGGGTGCCGCCAGATCCCGGAGACGCCGACCCGCACCCCGCTTCTCGTGCGCAGGTCGTGCCGGTCGAGCACGACGGTGAGCTGCCGGGGCGCGCGGTCGCGCGGTCCGAGCAGGCCGCGCTCCTGGGTGCAGTGGGCGGCGGTCACGACCCGGTCGGGGGCGATGAGGGCGCCGCCGCAGAACTGGGAGCCGCGCGCGTCGAGCAGGGCGGCCACCCACGGCGCGCGACCGGCGACGGAGCCCCCGACGACGGCGAGCGCGGCGGGTGCGGCGACGAGCTGGGAGGCGAGCTGGACCGCGACCAGGGCGAGGGCGGCGACTAAGCGGGCGCTGATGCGCATGGAGCACCTCTTTACGACGAGTAGCCGAGTGGCGACTCACCGTAGCTGCACCACAAAGATCACATCAAGTCAGGATATTTTCCTGTTAAGATGCCGTAGTTCCGAAAAATCCACGGTCTGTGTCCTGCGTCACCGCTGTCTGTCCGGACCATGAGGGGGTACTTCCGTTGCAGTTCGACCTGACCACGCTGCCCGCGTTCCTGATCGCCTGCGCGGTCGTGGTGCTCACCCCCGGCGTGGACTCCTTCCTCCTGCTGCGCACCTCGATGCGCTCGGGCACCCGCGCCGGCCTGCTGGCGCTGGCGGGCATCCACACCGCCGCCGCCATCCAGGTCGCGGTCGTGATCTCGGGCCTGGGCGTGGTGATCGCGGGCTTCCCGCCCGCCCTGACCGCGCTGCGCTGGATCGGCGCGGCCTACCTGCTGTACCTGGCGCTGTCGATCACCCGCGACCTGGTGCGCAACCGGGGTCGGGCGCCCGAGGAGGGCGAGGTCGTCGCGGACCGGCCGTTCCGGCGCGGCTTCCTGACCAACATCACCAACCCGAAGATGCTGCTGTTCTCCCTGGCGTTCCTGCCGCAGTTCATCGGCTCCGGCGACCCCACCCCGCAGCTCGCGATGCTCGCGGTGGTGTTCCTGGCGCTGGCCGCCGTGTGGGAGGGCACGATCGTGCTGGCCGCGTCGGCGGTCGGCGGGCGACTGCGCAAGCCGGGCGTGACCACCGCGCTGGACGTGGTGTGCGCGGCGGTCTTCGCCACCATGTCGGTCGGCCTGGTCATCTGACCCCGGCCCCTCACGACCGTCAGGTGTAGACGCCGACGCGGGTGTACACGCCGGGGTACTCCGGCCGGGCGCAGCCGACGCCCCAGGACACCAGCCCGGCGAGCCTGCCCGCGATGATGAACGGCCCGCCCGAGTCGCCCTGGCAGGCGTCCTTGCCGCCGTTGGGCAGCCCGGCGCAGAACATCGACGACGACTGGTAGTAGCCGGGGTACGCGGCGGCGCACACCTCGTTGGTCTGGAGCGGCACGGACACCTTCCGCAGCACCGGCGAGGTGCTCCCGCTCTCCGAGGTGCGGCCCCAGCCGAACGCGGTGCCGGTGATGCCCGCCCGGTACAGCCCGGTCTCGGACGGCTTGGCCAGCGCGATCGGCTCGTACGGCATCGGCGTGGACGTCAGCAGGTACGCGATGTCCGCGCCGCTGGTCGCCGACCGGTAGGCGGAGTGGACGTACACCTGGGACACCGGGTGGACCGTGCCGCCGGGCTTGGTCACGTCCAGCCTGCCCGCCACCACCAGCACGTCGCGCCCGGTGAGCCCGTTGACGCAGTGCGCGGCGGTCACCACCTGGTACCGGCTGACGATCGCGCCGCCGCAGAACTGCCTGCCGTTCTGGTCGGCCAGCGCCACCACCCACGGGTAGGGGTTCGGGGCGTCCACGACCACGCCGCCGACGATCCTCGGGTCGGCCCCGGCGGGCGGCGCCACCGCCACGCCGGTGAGCAGCAGTGCCAGCGCCATCGCCACGCGCATCAGAGTCCGCATACCGGCCAACCAAACCCGGCCGCCGCGACCGCACAACTCGGGCACACGGTCGGGTGATCGGGTGTGGTCGGCCGGTGCGGCGCTCAGCCCTTGAGCTGCTGGTCGATCAGCGCGCGGTAGGCGGTGATCCGCGAGTACACGCCGGGCTGGCCGGGCCGCGCGCAGCCCTCGCCCCACGAGGTGACGCCGATCAGCGCGCCGTTCGCGACCAGCGGGCCGCCGGAGTCGCCCTGGCAGGTGTCGATGCCGCCGCGCGGGTAGCCCGCGCAGACCATGGCAGCCGGGTCGAACCGGGCGTAGTCGGCGGTGCAGTCCTGGTTGGACATGACCGGCACGTTCGCGCCCAGCAGCACCTGGGAGGCGGCCCCGATCTCGGCGGTGCGGCCCCAGCCGAGGACCTTCGCCACCGTCCCCGGCGCCGGGTCGGCGGACGCGAGCGGCAGCACCCGGTTCGCGACCGGCCTGGCCAGCGTGAGCACGGCGACGTCGCTGCCCTGCTCGGCCGACGAGTAGAACGGGTGCTTCCAGATCCGGGCCACCCGCAGCGTCTCACCCGCCTGGGTGCGCTTGTCCTCGCGCCCCGCGACGACGACGAGCCGCTCCGGGGCGGTGCCCGCGACGCAGTGCGCGGCGGTGACCACCTTGGTCGGCGCGACGAGCGTCCCGCCGCAGAACTGGCTCCCGGTCGTGCCCGCCAGGAACACCACCCACGGGTGCTCGGCGATGGACGCGCGCGTCCCGCCGACGACTCTGGGTTCCGCCGCCGCGGTCGCGACGCCCCCTCCGCACAGCACCGCGAGAACGCTGAGAAAAACGGCAAGCCTCATCGCCCCTCCTACGCCTAGTGGGGAGCGCCCGAGTCGGGGCGCCTGCCAGGAGGTTAGCCCTGAAAGACCAGGTCGATGCGCCGAAAGGAGCACACGACCTGGTCGGACCAGCCGGGCGACCCGGCTGTCGCAGCGGCGCCCCCGCCGGGTCGCGCCGCGTGCTGTCGATCAGCTCCCGGAGGGTGAACCGAAGCCGGAGAAGCGCCCCCTGACCTTGCCCGCCGCGTCCGCCACGACCCCGCCGAGGTCGTTGACGACCTTCATCAGCGGGTCCTCGGACTCGGCGGCGTCGGACTTGTAGGAGCGGGCCGCCTCCTTGAGGTCGTCGGTGAACGTGCTGGAGGCGTGGTCGTCCTCGCGGCGCCGGTAGTCGCCCGACAGGATGGCCCGGTACTCCTCGCTCGCGGCCCAGCGCTGGAGCTCGGCGGCGCGCACCACGGCCATCGGGTGCGTCAGCGGCCAGGTGCGGATCAGCTTGAGGACGCTGTCGCGCACGTCCTCGACCTGCTCGTACTCCTTGGCCTGCTTGAGGAACTCGGCGGTGTCGACCTGGGTGAGGTCCATGCCGCCCGCGAGGGCGACGTGCACGCGCAGCGCGGCGGCCGGGTCCTGGGCGCACAGCAGGCCCGCCCGGTCGCAGCTCAGCTCGGTCTTGCGGTACCACTCGTGCAGGGCGGCGATGACGGCGCGGACCGCCCAGTAGCCCGCGGGCATCCAGCCGAGGCTGTGCTGGAGCTGCATCAGCCGCATGAGGATCGTCTGGTAGAGCGCGTGGCCGGAGAGCACGTGGCCCATCTCGTGGCCGATGGCGAAGCGCAGGCCGTCGTGGTCGAGCAGCTCGACCAGGCCGGTGGTGAGCACGATGAACGGCTTGTCGATGCCCAGCGCCATCGCGTTCGGCTGCGGGTTGCGGGAGATGAACAGCTCGGGGACCGGGTCGAGGTCGAGGGTGGCCGCGGTCTCGTTCCGCAGCCGGTCGAGGGCCGGGTACTGCTTCGGGCCCACCCGGATGGAGGTCGCCAGGTAGCCGAGGCGCTCGCCGCGCTCGGTGAAGGCGCCCGCGACGGACTTGAGGACCGGACCGATGCCGGGGACCGCGCGCAGGACCGCCAGCGCGCCCCGGTCGACCGGGTGCTCGTAGGCACGGGGGCTGATGCCGGGGAACCGAACCCTGGAGGTCGACCGCTCGATCTCTTCGCTCATCCTCCCAGCGTGCCACGCCCCACCTCCCCCTACTCCCCGTTCGGGCGAATCACGGGCACACTGACGGGGTGGAACCGGATGTGCTGGGCGACGGGTTCGAGGTCAGGACGCTGCCGCTGGGCTCGGAGGCGAGCGCGGCGCTGGTGCGCAGGCGCGCCGACGGGGCGGCCGAGCGCGGGGCCGTGCTGTACGTGCACGGGTTCGCGGACTACTTCTTCCAGCGGCACGTGGCCGAGCACTTCGCGTCGCTCGGGTACGACTTCTACGCGCTGGACCTGCGCGCCCACGGGCGGTCGCTGCGGCCGGGCGAGGTGGCGAACCACGTCGAGGACCTGTCCACGCACTTCGAGGAGCTCGACGCCGCCGTGCGGGTGGTGCGCGAGGAGGACGGGCACCGTGGGCTGGTGGTGATCGGGCACTCCACGGGCGGGCTGACCACCAGCCTGTGGGCGCACGAGCGGCGCCAGGACGGGGCGCTGGACGCGCTGGTGCTCAACAGCCCGTGGCTGGACCTGGCCGAGCCGTGGGTGATGCGCACGGTCGGCACGGCGGTGGTGCGCGGGGTGGGGCGGGTCGCGCCGAAGCTGGTGCTCAAGCCGGGCCTGGGGCCGGTGTACGGGGAGAGCATCCACCGCGACCACCACGGCGAGTGGGAGTTCGACACCGCGTGGAAGCCGATCGAGGCATTTCCGGTCACGGCCGGGTGGTTGCGGGCGGTGCGGGTCGGGCACGCGCGGCTGCACCGGGGGCTGGACGTGCGGGTCCCGGTGCTGGTGCTGCACTCGGCGCGCAGCCACCTGAAGGCGAGGCGGTGGTCGGCGGAGGCCATGACGGCGGACGCGGTGCTGGACGTGGAGCACATGCGCCGGTGGGCCCCGGGAATCGGCCGTGACGTGTCACTCGTCCAGGTGGACGGGGGGATGCACGACCTGTTCCTGTCAGCCGCCCCGGTGCGCGAGAGGGCACTGGCCGAGGTGGGCGCGTTCCTGGAACGTAAGGTCGAGCGGTGACCGTTCCCGACCCGAACCAGCTGCACCCGATGGCCGATCACCCGAGGGTGGTGCTGCTCAAGCCACTGGTCGACGCACCGAACATCGAGGTGGGCGACTACACGTACTACGACGACCCCGAGCGCGCGACCGAGTTCCAGACCCGCAACGTGCTGTACTCCTACGGCCCGGAACGCCTGGTCATCGGCAAGTACTGCGCTCTGGGCACGGGCACGACGTTCATCATGGCCGGCGCGAACCACCTGACCAAGGGCCCGTCCACGTTCCCGTTCACGATCTTCGGCGGCGCCTGGGCGGAGAAGACCGCCGACATCATGGCCGCCGCCCCCAGCAAGGGCGACACGGTCGTGGGCAACGACGTGTGGTTCGGCTGCGGCGCCACCGTCATGCCGGGCGTGACCATCGGTGACGGCGCGATCATCGCGACCGGCGCCGTGGTGACCTCGAACGTCGCCCCGTACACCGTCGTCGGGGGCAACCCCGCGCAGGCGGTGCGGCAGCGCTACCCCGACGACAAGATCGAGCTGCTGCTGCGCGCGGCGTGGTGGGACTGGCCCGTCGAGCTGGTCACCGAGCACGTGCGCGAGATCATGGCGGGCAAGGTCAAGCAGCTCGCCGACATCGCCGAGGAGAACGGGCTGCTCAAGCCCAAGCCCCGCTAGCGGCAGGACGACTTCCCACCGGGGGCCGGGTTCCGATCGGAACCCGGCCCCCCGTCGGTCCGGAGCGGCCCCGGTCACGCCGCCGCGGCCACCGCCTCGGGCTCCAGCGCCAGCTCCAGGACCTCGCGCACGTCCCCGACCAGGTGCACGGTCAGCGCGTCCCGCACGTCCCGCGGGACCTCCTCCAGGTCCGGCCCGTTGCGCGCGGGCAGCAGCACGGTCGTGATCCCGGCCCGGTGCGCGGCGAGCAGCTTCTGCTTCACCCCTCCGATGGGCAGCACCCGTCCGGTGAGGGACACCTCGCCGGTCATCGCCACGTCCGAGCGCACCGGACGGCCCGACAGCAGCGACGCGAGCGCCGACACCATAGTGACGCCCGCCGAGGGCCCGTCCTTGGGCACCGCGCCCGCCGGGACGTGGACGTGCACGCCGCGCCCGTCCAGGGTCGCGGCCCGCTCGTCGTGCGCCCGCAGGTAGGACAGGGCGATCTGCGCGGACTCCTTCATCACCTCGCCGAGCTGCCCGGTGAGCACCACGCCGCCGGCCCCGGTGCCGGGTTCGGCGAGCGCGGCCTCCACGAACAGCACGTCGCCGCCCGCACCGGTCACCGCGAGGCCCGTGGCCACGCCCGGAACGGCGGTGCGCTCGGCGGACTCGGGGGTGAACTTCGGCGACTTCAGGTAGCCCTCCAGGTCGCCGCCGTCCACGGTGACGGGCAGCTCGGCCCGGTCCAGCGCGACCCCGGCGGTCACCTTGCGCAGCACCCGCGCGAGCGAGCGCTCCAGCTGCCGCACCCCGGCCTCGCGGGTGTACTCCCCGGCGAGCCTGCGCAGCGCGGCCCCGGTGACCTCCACGTCGCCCGGCTCCAGCCCGGCCCGCTCGACCTGCCTGGGCAGCAGGTGGTCGCGGGCGATGGTGACCTTCTCGTCCTCGGTGTAGCCGTCGAGCCGCACCAGCTCCATGCGGTCGAGCAGCGGGCCGGGGATGGACTCCAGCACGTTCGCCGTGGCCAGGAACACCACGTCGGACAGGTCCAGCTCGACCTCCAGGTAGTGGTCCCGGAACGTGTGGTTCTGCGCCGGGTCCAGCACCTCCAGCAGCGCGGCGGTCGGGTCGCCCCGGTGGTCGGCGCCGACCTTGTCGATCTCGTCGAGCAGCACGACCGGGTTCATCGAGCCCGCCTCGGAGATGGCCCGCGCGATGCGGCCCGGCAGCGCGCCGACGTAGGTGCGCCGGTGGCCCCGGATCTCCGCCTCGTCGCGCACGCCGCCGAGGGCGACGCGGACGAACTTGCGGCCCATCGCGCGGGCGACGGACTCGCCGAGCGAGGTCTTGCCCACGCCGGGCGGCCCGACGAGCGCGAGCACCGCGCCGCCGCCGCGCCCGCCGACCAGGCCCATGCCCCGGTCCGCGCGCCTGCGCCGCACCGCCAGGTACTCGGTGATGCGCTCCTTCACGTCGTCCAGGCCCGCGTGGTCGGCGTCGAGCACGGCCCGCGCGCCCGCGATGTCGTAGGAGTCCTCGGTGCGCTCGCCCCACGGCAGGTCGAGCACGGTGTCGAGCCAGGTGCGGATCCAGCCGACCTCGGGGGACTGCTCGGAGGTGCGCTCCAGCTTGTCGACCTCGCGCAGCGCCGCCTCCCGCACCTTCTCCGGCAGCTCGGCGGCCTCCACGCGGGCCCGGTAGTCCTGCTCCTCGGTGGCGGGCTTGCCGTCCAGCTCGGCCAGCTCCTTGCGGATGGCGGCGAGCTGCTGGCGCAGCAGGAACTCCCGCTGCTGCTTCTCCACGCCCTCCTTGACGTCCTTGGCGATGGACTCGGCGACGTCCAGCTCGGCCAGGTGCGCCCGGCCCCACTCCAGCAGCCGCTCCAGGCGGTCGCCGACGTCGCCGGTCTCCAGCAGCCACACCTTCTGGTCGTTCTCCAGGTACGGCGCGTACCCGGCCAGGTCCGCGAGCGCGGAGGGGCCGTCGACCTGGCGGACCGAGTCCACGACCTGCCAGGCGCCGCGCTGCTGGAGGATCGTGGTCACCACCGCGCGGTAGTCGCGGGCCAGGGAGCGCGCGCGCTCGTCCGGCGGCGGCTCCTCGACGACGGTGGCCTCCACCCACAGCGCCGCGCCGGGCCCGGTGGTGCCGGTGCCGATGCGCACCCGCTCGGTCGCGCGCAGCACGGCGGCGCGCTCGCCTCCCGCGAGCCTGCCGACCTGCTCGACCGTGGCCAGCGCGCCGACCTTGGCGTAGCGGCCGTCCAGCCGGGGAACCAGGAGCACCCGCGCGCCGTTCACCCCTCCGGCGGCCGAGGTGGCCGCCTCGACCGCGGCCCGCGCCTCGGCGCCCGCGTCCGAACCGGTCAGGCGCACCGGGACGACCATGCCCGGCAGCACGACGGTGTCGTCGAGGGGCAGGACCGGGAGCGCCAACGTGTCACCCATGCGAAGCCTCCAGAGTTGAGTCTGACAGGCTCAACCGAGTTGAGTCCCCGGTTGTTTCCGAGTTCTGTTCGCCCAGAGCGAGACCGAGGAGTTCCGCGCGCGGGGGTTGTGCGCGGCGACCGGGGTTCGACACGATCGGCGGTTCCACCCGGTCAAGAGGAGAAGGCTTTTATGGAGCAGGCGAGCTGGGTCCCCGCGTCGGTGGACCTGGACCGACCGAGCACGGCCCGGATGTACGACTACTACCTGGGCGGGTCGCACAACTTCGCCGTGGACCGGGAGGCGGCCAAGGCGGTGGAGCACGTCTTCCCCGGCATGTCCGGGGCGGCGCGCTCGCTGCGGACGTTCCTGCGGCGCTCGGTGCGCTACCTGCTGGACCAGGGCATCGACCAGTTCCTGGACCTGGGCTCGGGCATCCCGACCGTGGGCAACGTGCACGAGATCGCCCAGGCCGCCAACCCCGCGGCGCGCGTGGTCTACGTGGACATCGAGCCCGTCGCGGTCGCGCACAGCACCGCGATCCTGTCGGCGAACCCGCTGGCCACCGCCATCCAGGCGGACCTGCGCGACCCGGCGTCCGTGCTGGAGAACGAGGACGTGCGGCGGCTGCTGGACTTCGACCGGCCGATCGGCGTGCTGATGGTCGCGGTGCTGCACTTCGTGCCGGACTCCGACGACCCGCACGGCGCGATCGCCCGGTACCGGGACGCGCTGGTCCCCGGCAGCTTCCTGGCGATCTCGCACGCGACGGTTGAGGGCGTGCAGGTCGACGCCGAGCAGGACACCGCGCGGGTGCAGGACGTGTACAAGCGCACCGAGAGCCCGCTGATCTTCCGCGACCGGGCCGAGGTGGCCAAGCTGTTCGACGGGTTCGAGGTGGTCGAGCCGGGTGTGGTGCCGCTGTCGGAGTGGCGGCGCGACTCGGACGACGCCTACACCAGCGCGTACGTGGGCGTGGGCCGCAAGGTCTGACCCGGCGCGATCGCGGTGGGGCGCCCGGAGCTCCGGGCGCCCCACCCGGTCACGTCACCCGGTCCCGAGCAGGCCCGCTCACTCGGCCGGGTTGAGCCGCAGGTCCGGGTTCACCGGCGGCGCACCGTCGAACGGGCCGGGCACCAGGCCGCCGAGCTGGTCCAGGGTCAGCCGCACGTCGGCCGAGAACGGGTCGGTCCCGGCGGGCGGGTCCGCGAACCAGGACTTCAGCTCCTCCGGCACCGGGTAGCCGTCCGCCAGCTCCCGGTACTGCTCGCCGCGCTCGCGCGCCTGCCTGGCCAGCTCCTGGTACTCGCGCATGGCGATCCGCATCCGGATCCACCGGTACCGCGCGGTCCGCTCGCCGCCCTCCTGGGTGAACCTGGTGCGCAGCAGCTCGCCCGCGACCCGGCCGCGCTCGGCCAGCGCCCGGATCGTCTCCGGCCGCATGAACAGGTTCGTGCCGCCCTCCCCGCCGCGCAGCCGCACGTGCGCGATCCGCCCCCGGAAGCCCGGCAGCGCCGACTGCATCGCGTCCCGCCAGCCGAGCGCGGTGTCCAGGACCGCCTGCGCGAACCCGACCGCGCCGGTGACCGACCGCCACGGCCTGCCCTCCTGCGAGGCGTCCTGCTCGGGCAGCCACACGTCCTGCACGCCCGGCGCCGGGTAGCCCTGCAGGGTGAGCCCGAACGTGGGCCAGCGGGGCAGCAGGGTGTCGAAGAAGTGGATGGGGAAGTTGCTGGTGATGCCGCCGTCCGAGAACCAGTGCACCCTCGGCTCGGGTTCGGCGCGCACCAGCGGCACCGCCGAGATCAGGCCGGGCATCGGCATGCTCATCCGCACCGCGAGCGCCACCGGGAGGTCGGCGGGCAGCACGCGCAGCGCGGTCGCCGGGTGCAGCGGGCAGCGCTTGTCGTCCGCGCCCTCGTCGCCGAGCAGGTCGACCACCCGCGCGGGCAGCACCCCCGCGAGGCAGTCGGCGCAGAACAGCCACCGGTCGTCCGAGGTGAACGGCAGCCTGCACGGGCGGCCCTCGGACACGTCGGTGCTCATCAGCACCAGGTTCGTGGTGAGGTCGGAGAAGCGCAGCCCGCGCACGCCCGAGAGGTGGTCGAGGGAGTCGGCGAGCCAGTCGCTCAGCGGCGGGACGTCGGTGGACTTCGGCATCCCGCAGCGGCGGTCCCACCAGCTCGCCCGGTAGCCGCCGGTGCCGGGCACGAGCCCGAAGCCGATGGACACGGCCCGCTCGCGCACGAACCTGCGCACCCCGCCCGCGTAGATCAGGACGACCGCGCTGGCCAGCCCGAAGCCGAGCACCAGCCACACCACCCCGGCGGTGGCCGCCGACGCCAGCACCGCCCAGTCCACGCGCAGCCGGGGGACGATCGGGTAGAGCGGGACGGCAGCCAGCAGCAGCAGGCCGATCCGGGCGGGCAGCGGTCCGCGCCCGGTGGGCAGCGCCTTCACCGCCACCCACGGCACCGTGACCGCCGCCACCACGACGATGGCCGCCAGCCCCCAGGTCGGGAAGCCGGGCCAGGCGACCGCGCCGAACCACAGCGCAGGCCCGGCCAGCCAGACCAGCAGCGCCGCGGCGAGCGCGGCCTTGGCCCGCGGGCCGATCGCGCCCAGCAGCGCGAACACCAGGGACACCGCCGCGCTGCGCCCGGTGGTCTCCCGGCTCTGCATGGTCGCGGTGACCAGCCGGTAGAGCTTGCGGGTGGCCCTGGTCGGCTGGAACAGCTGGGCGAGCCGCTGCCGCCCGGACGCGAACCAGGTGACCGTGTCGGCGAGCCGGTCGAACCCGCCGCTGTCCCGCCCGCGCTCGGCCGCCGCCGCGAACGAGGCCCCGATCGCCCCGGCCGAGGCCCCGCCGAGCGAGCGGAACCGGTAGTGCTTGGACAGCTCGACCACGGCCAGCGGGTAGACGATCCCGCTCGTGGCCCCGCCGCGCATGGTCAGGTCGCAGCACCTGTCGAAGTCCTCGTAGTCCCCGTAGTCCCCGTCGCCTGCCGCCATCACCGGATGGTCCCGCGCCGCGCCGGGGTGGCCGCTAGGGCCGTTTCGGGGAGGGCGCACGGGTGGAGCAGTCGTGCGCGCCCCGACCGGTGCTGGCCACTCGGTGCCGGCTGGCCAGCGCTCCCCGCTCAGCGCCGCCCGGTCAGTGCCGCTTGGTGGGTGGGGCCAGGAAGTCGTCCAGCAGCACCGGGGTCATCCCGTCCGCCTTCGCGCGCTCGCAGAACGCGGTGAAGTCGGCCACGAAGCTGTCCCGGAAGTGCATGAGCACGATGTCGCCGCCGCGCAGCTTGTCCCCGACCTGGAACTGCACCACGCCGTCGTTGACCGCCGCGGTCCACAGCACCACCGCCCGCATCCCGCACGAGGCGGCGGCGCGGCGGGTGTTCAGGTCGTAGTTGCCGAACGGCGGGCGGAACAGGGTCGGCCTGGTCCCGAGCGCCGACCCGAGGTAGTCGGCGTTGCCGCAGATCTGCGCGCGCTGCGCCTCGTACCCCATGCCGCGCAGGTTCGGGTGGTCCGCGGTGTGGGCGTGCACGTGCGCGCCCGCGCCCTGGAGCGCCTTGAAGTACGCCGGGTCCGGCTGCACGTGCGTGGTGTTGAGGAACAGCGACGGCTCGATGCCGGAGTCGCGGACGAGCTGGAGCGCCTTCGGGTGCCGGACCGCGCCGTCGTCGACGGTCAGGAACACGTAGGGCTTGTCGGTCTCGATGCTGCTGACCACCGGCGCGAGGTCGCCCTCCTGCGGCGGGGCCTCCTTCTGGGCCGTGCCGTACCGGTAGGGCTGCTGGAACAGCTTCGGCGGCGGAGGGGGCGGGGTGGTGGTCGTGGACGTGGTCGTCGTGCTCGGCGGCACGGGCACCGCCCTGGGGGCTTCGGGAGCGGGCGAGCAGGCCGCCAGCAGTCCCAGGGCAGCCGTCATCGCTACTGCCAACGCGCGCATGGAGTGGATCCCCCCGGAGGATTGCTGTTCCTCCGGATGGGACGCGGGTGCCGCCATCCGGGTTGCACGGCGATCGCGAACCGCCGGGGATAGGGTCGGGCTCCGACAGCCAAGATCACCAGCGGAGGACCCGATGAGCCTCGACCGACCCGTCGCGCCGGACCCGTACTCGCTGCTCCCGACCGTGCCCGCGTTCCAGGTCACCTCGACCGACGTGGCCGACGGGCGGCCCCTGCCGCAGGCGCAGGTGTTCGAGGGCGGCAACACCTCGCCGCAGCTGTCCTGGAGCGGGTTCCCCGAGGGGACGAAGAGCTTCGTGGTGACCTGCTTCGACCCGGACGCCCCCACCCCGTCCGGCTTCTGGCACTGGGTCGCGGTGAACCTGCCGGTCTCGACCACCTCGCTGGACACCGGCGCGGGCGCGGACGACGCCTCGCTGCCCGGCGGCGCGTTCCACGTGCGCAGCGACTACGGCACCCGCGCGTTCGGCGGCGCGGCCCCGCCCCAGGGCGACCACCCGCACCGCTACTTCTTCGTGGTGCACGCGGTCGACGTCGAGGCGCTGGACGTGGACGGCGACGCCTCTCCCGCCGTGGTGAGCTTCAACCTGGCGTTCCACACCCTGGCGCGGGCGATCATCACCCCCACCTACCAGCACTGACCGCCGGGAACATCCGCCCGGACGAAGGGGTTGAGCACGGCGTGAGGCACTTCGACCTGGTTGTCATCGGCACCGGCTCCGGCAACTCCATCGTGGACGAGGCGTTCGCCGCCTGGGACGTCGCGATCGTGGAGAAGGGCGTGTTCGGCGGGACCTGCCTGAACGTGGGCTGCATCCCGACGAAGATGTTCGTCCACACCGCGGACCTCGCGGCGGGTCCGGCGAGCGCGGCCCGCTTCGGCGTGGACGCCTCGCTCGACGGCGTGCGCTGGACCGACGTGCGGGACCGGATCTTCGGGCGCGTCGACCCGATCGCCGAGGGCGGCAGGCGGTGGCGCGAGAGCGGCAGCGCGAACACCACCGTGTTCAGCGGGACGGCCCGGTTCACCGGACCGAAGACGCTCGACACCGGCGCCGGCGAGACCATCACCGCCGACCGGTTCGTGATCGCGGCGGGCTCGCGGCCGGTCGTGCCGGACGTGCCGGGCCTGGCCGAGACCGGCTTCCACACCAGCGACACGGTGATGCGGCTGGACCGGCTGCCCCGGCGGATGGTGATCCTGGGCAGCGGGTTCGTGGCCACCGAGTTCGCGCACGTGTTCTCGTCGTTCGGCGTGGAGGTCACCCTGGTGGCCCGCTCCGGCGCGCTGCTGCGGGCCGAGGACGACGCGGTGTCGGCCCGGTTCACCGAGCTCGCCTCGGCCAAGTGGGACGTGCGGCTGGACCGGCGCGCGGTGCGGGCCGAGCGGGTCGACGGGGTGGCGCGGCTGCACCTGGAGGGCCCGGACGGCCCCGAGGTCGTGGAGGCCGAGGAGCTGCTGGTCGCGGTCGGCCGTCAGCCCAACACCGACCTGCTGGACGTCGCGGCGACCGGTGTGGCCCTCAACGACAAGGGCAGGGTCGCGGTCGACGAGTTCCAGCGCACCTCGGTGGAGGGGATCTACGCGCTGGGCGACATCAGCTCGGACTACCAGCTCAAGCACGTGGCGAACCACGAGGCGAAGGTGGTGCGGCACAACCTGCTGAACCCGGACGCGCCGGTCGCCTCGGACCACCGGTTCGTGCCGTCGGCGGTGTTCTCGTCGCCGCAGATCGCCTCGGTCGGGCTGACCGAGCGGGACGCGGTGGCGAAGGGCGTGTCGTACGTCAGCGTCGAGCAGCCGTACGCGTCGATCGCCTACGGCTGGGCGATGGAGGACACCACCGGTTTCGTGAAGCTGCTGGCCGACCCGGTGACCGGGCAACTGCTGGGCGCGCACGTGATCGGGCCGCAGGCGCCGACCGTGGTGCAGCCGCTGATCCAGGCGATGAGCTTCGGCCTGGACGCGCGGTCGATGGCCAAGGGGCAGTACTGGATCCACCCCGGGATGCCGGAGGTCGTGGAGAACGCGCTGCTCGCGCTCCCGTTGAAGGACCAGCGCTGAGGGACCAGCGCTGAAGCACTGGCGTTGAAGCACTGGCGTTGAAGCACTGGCGCTGAAAGACCGGCACGGCACAGGGGGAGGCCCGGACCACTGAGGTCCGGGCCTCCCGCCGTGCCGAGGGGTGTCAGAGGGTGCGCGGCCGTCCGGCGATCACGCCCAGGGCGATGAGCGCGACGAGGACGCCCGCGAGCACGTACATCGACACCGTCCACGCGCCGGTCACGTCGCGCAGCACGCCGAACGCGAACGGGCCTGCGGCCGAGATGAGGTAGCCGATGCTCTGCGCCATGGCGGACAGGTTCGCGGTGTCGGCGGCGGTGGCGGTGCGCAGCGAGATGATCACCAGGGCCAGCGGGAACACGCACATGCCGGTGCCGATCAGCACGACCCACAGGCCGGGCGCGGCGACCGGCGCGATGGCCAGGCCCAGGATGCCCGCGATGGACAGCGAGCCGAGCAGGACGACCAGCCAGGACTGCGAGCCCCAGCGGGTGGCCAGCGGCGGCACGACGAGGCTGACCGGGACGCCGAGCACCATGGTGATCGCGAGCAGCATCCCGGCGGTGGTCCGGTCGACGCCGGAGTCGGCCATGATCTGCGGCAGCCAGCCCATGACGGTGTAGGCGAGCAGCGACTGGAGCCCGAAGAAGACGGTGATCACCCAGGCCAGCGGGCTGCGCAGCACCGAGGTGCGGCGCGCCGGGGCGGCGGGACGGGCGCCGTGGGCGGGGGCGGGGGCGGCACCGTGGCGGGCGCTGGCGGACCACACCAGCAGGGCGGCGGTCGACAGCAGCGCCCAGGTGGCGGCGGCGAGCTGCCAGGAGCCGAGCACGGTCTCCAGGGTCGGGGTGAGGGCGGCGCCCACCGCGGCTCCGGCGGCGAGCGCCGCGGTGTAGACGCCGGTGAGGAACCCGACCTTGTCCGGGAACGACTCCTTCACCACGACCGGGATCAGCACGTTGCACACCGCGATGCCCGCGCAGGCGGTGAACGTGCCGCCGAGCAGCACGGCCGGGCCGTCCAGGACCCGCAGGACCAGGCCGAGGGTGAGCACGACCAGCGACGCGCCGACCGCGCGGGCCATGCCGAAGCGGCGGCCCAGCCACGGGGCGGCGAACGCGGCGACGCCGAAGCAGACGGTGGGCACGGCGGTCAGCAGGCTGGTCCACGCGGTGGTGGCGCCGAGCGAGGCGCGGACGTCGCCGAGCACGGAGGCCAGGCTCGTGACGGCGGGGCGCAGGTTCGCGGCGGCGAGCGCGACGCCGACCGCGAGGAGGGTGCTGCCGACCAGCGCGGCGCCCCGGCCCTGGCGCGGTCCGGGGGCGGGTTCGGCCGGGGGCGCGGTGGCGGGTGCGGCAGTCGTCGGATCAGCGGTGGTCTGATCAGCGGCTCCGGTGACCGGATGTGTTCCCACCGTCGCGTCGTCACCCGGATCGGTGGCAATGTGGACGGACACGGGAATTCGGTCTGGCGGGATTTGCTGGATCGACACTCGGTTACTATCGCAGACATAGGATGTTTGGATGAAAGGATGCCGCTGTGCCGTTGGCCACTACTCGACGGGCGGGCCTCGTCGACCAGGTGATCGACCAGATGAGGGGGGCGATCGCCAGCGGTGAATGGCCGGTCGGCCGGCGCATCCCCCCCGAGCCGGAGCTGGTGACGGCGCTGGGCGTGGGGCGCAACACCGTGCGCGAGGCGGTGCGGGCGCTGGCCCACGCTGGCCTGCTGGAGGTCCGCCAGGGCGACGGGACGTTCGTGCGCGCCACGAGCGAGCTGTCCGGGGCGGTGCGCAGGCTGTGCGGCAGCGAGCTGCGGGACGTGCTCCAGGTGCGGCGGACGCTGGAGGTCGAGGGCGCGCGGCTGGCCGCGACCCAGCGCACCGAGGAGGAGCTGGCCCGGCTGGAGGTCGCGCTCGCCGAGCGGGACTCGGCGCTGGCCGCGAAGGACTGGGAGCGGCTGGTCGAGCGGGACGCGCAGTTCCACGAGCTGCTGCTCCAGTGCTCGCACAACACCCTGCTGGCCGAGCTGTACCAGGGCCTGACCGAGGCGGTGCGGGCCAGCATCGACGCGACCGTGCGCACCGCGCCGGACGACGACGACCTGTCCCACGAGGGCCTGCTCCAGGCGATCCGCGACGCCGACCCGGCGCGGGCGGCGCTGGAGGCGGGCGGGTTCCTGGAGGAGCTGCTGGAGCGGCACGGGGAGTAGCGGGCGGCGGTCGCCCACGAGGGGTTCGCGCGCACGGGCCGGGAGCGCCGCGCGCGGATCGCCCGCGCGCGCTCTCACCGCCGCGCCATCCCCCCAGCGCCATCCCCCCAGCGCCGTCACCCCAGCGCCGTCACCCCAGCGCTCCCGCACCGGCGCTCCCGCACCGGCGCCCGCACCGCCGCATCCCCGCCGCGCTCTCACCGCCGCGCCATCCCCCACGCCGTCACCCCCGCGTCGGGACCCACGCCTCCCAGACCTCCCGCAGCACCTGCGCCACGGCCCCGATCGCGGGTCGCCTGGCCGCCTGCGCGCGCCACACCACGAACACCCGCCGGGTCGGCCGGGGCTCGAACGGCACCGCGCGCACGCCCTCCGGCAGCACGCCCCGCCCCAGCCTGGGCAGCAGCGCCACCCCCACCCCGCGCTCCAGCAGCGCCAGCTGGGTCTCGTACTCGCCGACCCGGTGCGCCAGCAGCGGCTCGGCGCCCTCCGCCCGGAACGCGTTGACCAGCCAGTCGTGGCAGATCGTCCCCTCCGGCTGGCAGATCCACCGCTCCCCCGCCAGGTCCGCCACCCCGACCGCCGCCCGCCCGGCCAGCCGGTGCCCCGGCGGCAGGAGCACGTCCGCGTAGTCCTCCCCCAGCCGCACCCGCGCCAGCGACTCGTGCACGGGCAGCGGCGCGTTCACCCAGTCGTGGGCCACGGCCAGGTCCAGCTCGCCGCGCGCCACCGCGCCGATCGCCTCCGGCGGGTCCTGCTCGACCAGCCGCGCGTCCAGCTCCGGGTGCCGCACCGCCAGCTCCGCGAGCGCGGGCGGCAGCAGCCCGCGCGCGGCGGTGGAGAACGCGCCGATCCGCAGCTCCCCCACGACCTGCCCGCGCTGCCGCTCCAGCGCCACCTCGGCCCCCTCGACCAGGGCCAGCACCCGCTCGGCGGTGTCGGCGAGCAGCAGCGCCGCGTCGGTGAGCACCACCCCGCGCCCGCGCCGCTCCAGCAGCACCGCGCGGGTCTCCCGCTCCAGCTTGGTGATCTGCTGGGACACCGCCGACGGCGTGTACCCAAGCGCCGAGGCCGCGGCCCCGACCGAACCGTGCCGCGCCACCGCGTGCAGCGCCCGCAGGCGTCCCAGGTCGAGCATTCAGCAATGCTAAACCCCATGTTTCAGAACTTAGCTCTGGTGCTAAACGATTGGCCGGGCTGAGACTGGCGGACGTGAAACCAGCCCACTCCGCCGTCGCGGTGCTCGTCGCCGCCATCTGGGGCGTCAACTTCGTGGTCGTCAAGGTCGGCCTCGCGGAGTTCCCCCCGCTGCTGTTCTCCGCCCTGCGGTTCCTGCTCGCCGCCGTGCCCGCCGTGTTCTTCCTGGGAGGGCCGCGCGTGGCGTGGCGGTGGGTGTTCGGCGTGGGGCTGGCGCTGGGCGTGGTGAAGTTCGGCCTGCTGTTCACCGGGATGCACGCCGGGATGCCCGCGGGCCTGTCGTCGCTGGTGCTCCAGAGCCAGGTGGTGTTCACCGTGGCGCTGTCGGCGGTGGTGCTGGGCGAGCGCCCGCGACCGGCGCAGGTGCTGGGCCTGGCGGTGGCCACGACCGGGTTCGTGGTGATCGCCCTGGACTACCGGGTGTCGAGCCCGGTGTCGGCGCTGCTGCTGGTCGTGGGCGGCGCGCTCGCGTGGGGCGTGGCGAACGTGCTGACCCGCAAGGCCCAGCCGCCGGACTCGCTGCGGTTCATCGTGTGGGTGAGCGCGGTGGCGGTGCTGCCGCTGCTGGCGCTGTCGCTGCTGGTCGAGGGCCCGGAGGCGGACCTGGCCGCGCTGCGCGGCATGGACTGGGCGGGCGCCGGGTCGCTGCTGTTCGTGGCCTGGGTGTCGACGCTGCTCGGCTTCGCCCTCTGGGGCTTCCTGCTGCGCACCTACCCCGCGCCGCGCGTGGTGCCGTTCGCGCTGCTGGTGCCGGTGGCCGGGATGCTGTCCGGCTGGCTGCTGCTGGACGAGGAGGTCACGGCGGTCCGGTTGGGCGCGGCGGGGCTGGTGGTGGCGGGCATGGGGGCGGCGACGCTCACCCGCCCCCGCTCCCGCCGCCACGCCGAACCGGTCGTGGAGGCCGTGCCGGTGTAGCCCCCGCTCAGGCGACCGGCGGCGCCCCGGCCGGCGGCACGACCCGCAGCCCGCCCGGCGCCCCGCGCTCCAGCAGCGCCCGCACCGCGCCCGTGTCCAGGTGGTCCACGACCAGGTCGCCGAGCAGGTCCAGCTGGGCCTCGCGGCGGGCCGCGAAGTCGGTGTCCGGGGCGACCTCGAACCCGTCCCGCCCGGCGAGCCCGGCCACGTGCCGCAGGAACGCCCGCCGGAACCCGTTGTTCTCCAGCAGCCCGTGCCAGTGCGTGCCCACGACGCGTCCGCGCACCGCGCCCTCGACCTCGCCGCCCGGCAGCTCCACCAGCCCCGGCAGGTCGTCGGCGCGGCGCGCCACCCGGCCGTGGTGGATCTCGTACCCGGTCACCGGCTCGCCCAGCGCCACCCCGGTCGGCCGGTGCAGCGCCTTCTCCGGCTCGAACACCACGTCCACGTCCAGCAGCCCCAGCCCCGGCACCGGACCCGCGCCCGACTCCACCGGGTCGTCGATCGAGCGCGCGAGCATCTGGTACCCGCCGCACACCCCCAGCACCGGCCCGTCGTGCGCGGCGATCGCGTCGGCCAGCCCGGTGCGGCGCAGCCACGCCAGGTCCGACACGGTCGCCTTGGAACCGGGCAGCACCACCAGGTCCGCGTCGGCCAGCCGGGACGGCTCGGTGACGAAGCGCACGGACACGCCAGGCTCGCAGGCCAGCGCCTCCACGTCGGTGGCGTTGGAGATCCGGGGCAGCCGCACCACGGCCACCCGCAGCCACTGCCGCCCCACCGGGGCCTGCGGCCGTCCGATCACCCCGTCGGCCGCGTAGGACAGCGAGTCCTCGGCGTCCAGCCACAGCTCCTCGCGCCACGGCAGCACCCCGTGCACCGGCCGCCCGGTCAGCTCGCGCAGCTGCCGCAGCCCCGGTTCGAGCAGGGCGGGGTCGCCCCGGAACTTGTTGACCACGAACCCGGCCACGAGCGCCTGGTCGGCCGGGTCGAGCAGCGCGAGCGTGCCGAACAGGTGCGCCAGCACCCCGCCCCGGTCGATGTCGCCGACCACCAGCACGGGCAGCCCGGCGGCGCGCGCCAGTCCCATGTTCGCGATGTCGGTGGCCCGAAGGTTGATCTCCGCCGGGGACCCGGCGCCCTCGCACACCACGGCTTCGTGGTCGGCGCGCAGCCCGGCCAGGGTGTCGAGCACCACGGTCATCAGCTCGGCCTTGCGCTCCCGGTAGGACATGGCGGACACCTCGCCCGCGACCTTGCCCAGCACCACCACCTGGGAGCTGCGGTCGCCACCGGGCTTGAGCAGCACCGGGTTGAACCGCACGCTCGGCTCCAGCCCGCACGCGGCGGCCTGGACGGCCTGCGCGCGGCCGATCTCGCCGCCGTCGGGGGTGACCGCGGAGTTGTTGGACATGTTCTGCGCCTTGAAAGGCGCGACCCGCACTCCCTCCCGCGCCAACCACCGGCACAGGCCCGCCACCAGGACGCTCTTGCCCGCGTCCGACGTGGTCCCGGCCACCAGCACCGCACCACTCACAGCCGCACCCCTCCACCGGCGCCCGCGGGCTGCCATCATCCTCGTCATGGTCGACACGCCCGCCACCGCGGTCCTGCTGCACAGCCCGTTCCTGGGACCCGCCAGCCTCGCCCCGCTCGCCGACGCGCTCGCCGCGCTCGGCAGGCCGGTGCTGCCGCTGGACGTGCGGGTGACGGTCAACGCCGCACCCGTGCACCAGCGGATCATCGGCGGCCTCACCGACGCGGTCGAGGACTCGGGGGTGAGCGGCGACCTGGTCCTGATCGGGCACAGCGGCGCCGGTCCCCTGCTCCCCGCGTTCGCCGAGGCCCTCGAGGAAGCCCCCGTCACCGGTCTGGTCTACCTCGACTCCGACCTGCCCACACCCGGCCGCAGTTGGCGCGACACCGCGCCCGCCGAGCTGTTCTCCGCGCTGAAGGCCGCCTCGCGGGGCGGGCTGCTCCAGCGCTGGGACCGCTGGTTCGGCCCGGACGGGATCGCGGACCTGGTGTCCGACGCGGACCTGCTGGCCGAGATCACCGCCGAGGCCCCCGAGGTTCCGCTGGCGTTCCTGAAGGAGCCGCACCCGACGATCGAGTGGACCGGCCCGCAGGCGCTGCTGCGGCTGAGCCCCGCCTACGACGAGGCGTGCGCCCAGGCCGCCGCGCTGGGCTGGCCGGTCCGCGAGCTGGACCTGCACCACCTGGCCGCCGCCACCGACCCGGAGCCGGTGGCGCTGGCGCTGGCGGACCTGCTGGACCGGTTGGGCCGCTGACGGCCCGACCGGGGTTCGGGCTCAGCAGGTGGTGAGGATCTCCGCACCCTCGTCGGTGACGACGAGGGTGTGCTCGAACTGCGCGGTCCAGCTCTTGTCCTTGGTGGTGACGGTCCAGCCGTCGTCCCACATCTCGCCGTCGGCGCCGCCGAGCGTGATCATCGGCTCGATCGTGAACGTCATGCCGGTCTCGATGACGGTGGGCACGTGCGGCGCGTCGTAGTGCAGCACGATCAGGCCGTTGTGGAACGTGCGGCCGATGCCGTGGCCGGTGAAGTCGCGCACCACGCCGTAGCCGAAGCGGTTGGCGTAGGCCTCGATGACGCGGCCGACGACGTTGAGCTGCCTGCCGGGCTTCACGGCCTTGATCGCGCGCATGGTGGCCTCGTGGGTGCGCTCGACCAGCAGCCGCACCTCCTCGGACGCCTCGCCCGCGATGAAGGTGGCGTTGGTGTCGCCGTGCACTCCCCCGATGAACGCGGTGACGTCGATGTTGACGATGTCGCCGTCCTCGACCACGGTCGAGTCGGGGATGCCGTGGCAGATGACCTCGTTGAGCGAGGTGCAGCAGGACTTCGGGAAGCCCCGGTAGCCGAGCGTCGACGGGTACGCGCCGTGGTCGCACAGGAACTCGTGGGCGATCGCGTCGAGCCGGTCGGTGGTGACGCCGGGCACGACGGCCTTGCCCGCCTCCTGCAGCGCCTGGGCGGCGAGCCTGCCCGCGACGCGCATGGCCTCGATCACCTCGGGCGTCTGCGCCCACGGGTCGGTGTTGCGCTGCGGGGCGGGGCGGTCGACGTACTCCGGCCGCTCGATGTGCTCGGGGACGGGGCGCCTGGGGGACTGCGTCCCAGGCTTCAGGACGGCGCGCACGGACATGCCCCAACACTACGACGCCCGCCGGAGCGCCAGCAGGGGAGTCCGGGAAGCGGGAACCGTCAGCCGGTGGCCCGCAGGAACCTCCCCGTGGCGTCCACGGCGGGCGTGGAGGCGTTGGCCCCCAGCAGGAGCGTGGCGAACGCGACGTCGCCCCGGTAGCCGACGAACCAGCCGTGCGAGTTGACCCCGTCGCCGTACTGGGCGGTGCCGGTCTTGCCGCGCACGTCGCCGAGGTCGCGCAGCTGGGTCGCGGTGCCCGACTCGACCACCTCGCGCATCATCGCCCGCAGCGGCTCCAGGACGGCGGTGGACGGCGCGGGCGGCTGCCGGTCGGCCTTGGTGGCCTGCTCGCGCATGAGCGTCGGCGTGGGCATGGCGCCGCCCGCGGCGGTCGCGGCGACCAGGGCCATGCCGAACGGGCTGGCGACCACCTTGCCCTGCCCGAACCCGTCCTCGGCCCGCTCGACCACGTCGGACGCCTCGGGCACCGAGCCGGTGATGGTGGTGATCGCCGGGATCTCGAAGTCCACGCCGAGGCCGAACGACGCGGCCTGCTCGGTGAGCGCGGCGGCGGGCAGCTCGGCGGCGAGCTGGGCGAAGGTGGTGTTGCAGGAGAACGCGAACGCCGTCCGCAGCGGGACGGCGCCCTTGTCGAACTCCTTGTCGTTGGGCACGATCCGGCGGCCGTCGACGGTGGTCCTGGCGGGGCAGGGCAGCGGGCTGTCCGCGTTCGCCTTGCCCGAGGCCATGGCCGCCGCCGCCGTGACGATCTTGAACGTGGAGCCGGGCGGGAACTGGCCGGTGAGCGCGATCGCGCCCTGCTCGTCGGCGGGGCCGTTCTGCGCCACGGCCAGCACCTCGCCGGTGCCGACCTTCAGCGCCACCAGCATCGCGGGCTGCGCGATCGGCTCCAGCGCGTCCTCGGCGGCGTCCTGCATCCGGCGGCTGAGCGTGGTGGGCACGGCGTGCGCGGGCTCGGGCTGCTGGTCGAACAGCGTCTCGACCTCCTGCCCGGAGGAGTTGGCGGTGTAGACGCGGAACCCGGCCTCGCCCGCGACGGTGTCCTCGACGGACTTGCGGATCGCGGGCAGCACCTGCGAGCCGTAGTCGCGGGAGGGGGCCAGCAGGCTCACCTGGCTGGTGAAGCGGACGCCGGGCAGCTCGTAGATGGCGGGCTTGACCGACTGGTAGTCGGCGTCGCGCAGCGCGGCCACCAGGTACGACTGGCCCTCCGGGACGGCAGCCGCGCCGTCGGCGACGGTCTTCGCGGTGATCTTCCCGTCGAACCGGGACAGCGCGCCCGCCAACGCGGTCGCGACCGCGTTCAGGTCCCCGGCCTCCTTCGGGCTCAGCAGCACCGAGACCACCGTTTCGGGTGACATCAGCGCGGTGCCGTCCCGGTCCAGCACGGGGGCGAGCGCGGGCCGCGCCTCGGCGAACCCGAGCGACTGCTGCGCGCCGAGCTTGGGGTGCACGACCGAGGGCGCCCAGTGCACCTTCCAGTCGTCGGCCTCGCGGCGCAGCTCCACGGTGGTCCGGTACTTCCACCGGTGCTCGTTGGGCAGCTGCCACTCCAGGGTGGCTTCGGCGGGCGCGGTGGCCCCGCTCTGGTCGCCGACCGCGTCGACCGAGGTGGTCAGCCCGGTGGCCCCCAGCGCGCCGCGCACCTTGTCCAGCAGGTCCTTGGCGGACGCGGGGTCGTCGGTGAGCTCGGCGGCGCCCAGGGTGTCCCCGGAGGCCACCTTGGACAGGAAGTCGCCGAGCGCGTCGCCCGGCCCCGGCTCGGACGTGAAGAGCCCGCACCCGGAGAGCAGCAGCAGGAGGCACACCGGACCGGCCAGCTTGGGCAGCAGCACCACCGCAGTATGCCCCCGGATCAGAAGAGCACGGTCGCGTACTGGCCCACCTGCGTGAACCCGATCTTGCGGTACGCGGCGCGGGCGGGGCTGTTGTAGCCGTTGACGTACAGGCTCGCGGTGCGCCCGAGGCCCCGGACGAGCCGGTCGGCCACGGCCGCCGTGCCCGCCGCGCCGACGCCGTGCCCGCGCCGGTCCGGCCGCACCCACACGCCCTGGATCTGGCCGACCTGCCGGGACATGGCCCCGATCTCGGCCTTGAACACGACCTCGCCGTTCTCGAACCGGGCGAACGCCCGCCCGGACGCGATCAGCTCGGCCACCCGCGCCCGGTAGCCCGCGCCGCCGTCCTCGACGCACGGGTCGACGCCGACCTCCTCCACGAACATGGCGATCGCGGCGGGCAGGTAGCGCTCCAGCTCGGCGGGCCGCACCGGCCGCACCAGCGGGTCGGGGCGCACCGACGGCGCGCCGCCCATGGCGAGCAGCGGCTGGTCGGCGCGCACCTCGCGGGCCGGGCCCCAGTCGCGCTCCAGCTCCTCCCACAGGCCGATGACCTGCTCGGCGGGACCGACCAGCGAGGAGCACGTGCGGCCCCGCCGCCGGGCCCGGTCGGCGAAGCCGCGCAGCGCGGCCTGGCCGCCGGACAGCGGGATCAGGTTCGGACCGGCGAAGCACAGCGCGTCCACGCGCCCGCCGCGCAGCGACCGGTGGTCGAACGACCAGACCTCGCCGCCCAGCCGCCACGGGTCCAGTCCCACGGACTCCACCCGCGCGGCGACCATGCAGGACGCCACCGGGTCAGCGGCGAGCGCCGCCAGCACCCCGGTGAGCTCCCGGTCGTCGAGCACCCTCGCTCCGGCAAGCCTCAGCACACGGCCAAGCCTGCCAGAGAACGCGCCGGAGCGGGGTGCCCGCCACCCGCTCAGCCGACCGTGACGACGGGCTCGCCGGAGGCCTCGGTCTCGCCGACCTCCTCGGCGATGCGCATCGCCTCTTCGATCAGGGTCTCCACGATCAGGTGCTCGGGCACGGTCTTGATGACCTTGCCCTTGACGAAGATCTGGCCCTTGCCGTTGCCGGAGGCCACGCCCAGGTCGGCCTCGCGGGCCTCGCCGGGGCCGTTGACGACGCAGCCCATGACGGCGACGCGCAGCGGCACCTCCATGCCCTCCAGACCGGCGGTGACCTGCTCGGCGAGGGTGTAGACGTCCACCTGGGCCCGACCGCAGGACGGGCAGGACACGATCTCCAGCTTGCGGGGACGCAGGTTCAGCGACTGCAGGATCTGGTTGCCGACCTTGACCTCCTCCACCGGCGGGGCCGACAGGGAGACCCGGATCGTGTCGCCGATGCCCTGGCGCAGCAGCGCGCCGAAGGCCACGGCGGACTTGATCGTGCCCTGGAACGCGGGGCCCGCCTCGGTGACGCCCAGGTGCAGCGGGTAGTCGCACTGCTCGGCGAGGATCTCGTAGGCGCGCACCATGACCACGGGGTCGTTGTGCTTGACGGAGATCTTCAGGTCGTGGAAGTCGTGCTCGGCGAAGAGCGAGGCCTCCCACAGCGCCGACTCGGCGAGGGCCTCGGGGGTGGCCTTGCCGTGCTTGGCCATCAGGCGCGGGTCGAGCGAGCCCGCGTTGACGCCGATGCGGATGGGGGTGTTGTGGTCGCGGGCCGCCGCGGCGATCTCCTTGACCTTGTCGTCGAACTTCTTGATGTTGCCGGGGTTGACCCGGACCGCCGCGCAGCCCGCCTCGATGGCGGCGAACACGTACTTCGGCTGGAAGTGGATGTCCGCGATCACCGGGATCTGGGACTTCTTCGCGATGGCGGCGAGCGCGTCGGCGTCGTCCTGCGTGGGGCAGGCGACCCGGACGATGTCGCAGCCGGACGCGGTGAGCTCCGCGATCTGCTGGAGGGTGGCGTTGACGTCCGCGGTGACCGTCGTGGTCATGGACTGCACCGACACCGGGGACTCGCTGCCGACGCCGACCGACCCGACCTTGAGCTGGCGGGTCCTGCGCCGCTCGGACAGGACGGGAGGCGGCAGCGCAGGCATACCGAGCATGACGCCGTCAGTCATGGGACAAGCACCTTTCGGGGAGGCACATCAGGGGAGCCGGATGGGGTTGACGATGTCCGCGGTGATCGTCAGCAGCGTGATCGCGCCGCCGACGAAGATGGCGAAGTAGGTCAGCGGCAGCAGCCGCAGGTAGTTCACCGGGGGCCCCGCGGGCTTGCCGCGCAGCTTGCGGACCCAGTCGCGCACCCGCTCGTACAGGTTGACGGCGATGTGGCCGCCGTCCAGCGGGAGCAGCGGCAGGAGGTTGAACACGCCGATGAAGAAGTTCAGGCCCGCCAGCATGAGCCAGAAGAAGTGCCACAGGCCCGCGCTCACGGCGTCGCCGCCGAGGATGGAGGCGCCGACCACGCTGACCGGGGCCTCCGGGTCGCGCTCGCCGCCGCCGATGGCCTTGATGACCATGGGGATCTTCTCGGGGAACTTCATCAGGCCGCGCCAGGTGTTGGCGAACATGTCGCCGGTGTACTTGGTCGCGCCGCCGACCGCGGTGAGCGCGTTGTACTCGTACAGCCGGGACTTGGCGACGCCGACGACGCCGACGGTGTCGACGTAGGTGGAGCCGTCGGCGCGCCGCAGCTCGCGCTCGACCTGCGGGATGTCGACGGTCAGCTTGACCTCGTCGTCACCGCGCAGGACGACCACCTCGGTGGGGCCGCTGCTCTGCTGGATCTTCTTCTGGACCTCGGTCCAGGTCGGCAGGCGCTGGCCGTCGACCGCGACGATCCGGTCACCCTGCTGCACGCCCGCGCTGACGCCGGGCGTCGGGTCGGTCGGCGCGCAGGTCGGGTTCTCCTTCTTGGCCTCGGCGGCGGTGGCGGGCACGCACTGCGAGACCTTCGACACCACGGCCTCGTCCCGGATGTCCGGCAGGCCGATGGTGGCGGCCATCGCGTACAGCACGACGAAGCCGACGATGAAGTGCGTGATGGACCCGGCGGAGAGCACGACGACGCGCTTCCAGGTCTTCTGCCGGTAGAAGGCGCGCTTCTCGTCCTCGGGCGACAGCTCGTCGAGCGCGGTCATGCCGACGATCTCGCAGAAGCCGCCCGCCGGGATGGCCTTGAGGCCGTACTCGGTCTCACCCCTGCGCATCGACCAGACGCGCGGGCCGAAGCCGATGTAGTACCGGGTCACCTTCATGCCGAAGGCCTTGGCCGTTGCCAGGTGTCCCAGCTCGTGCAGCGCGATCGAAATGCCGATGAGCAGCGCGAACAGCACCACACCCAACACGAACGCCAC

Protein sequences of DBSCAN-SWA_1

>CP029607|6972638:7023370|6997171_6997786_+|AXX33189.1|DBSCAN-SWA
MQFDLTTLPAFLIACAVVVLTPGVDSFLLLRTSMRSGTRAGLLALAGIHTAAAIQVAVVISGLGVVIAGFPPALTALRWIGAAYLLYLALSITRDLVRNRGRAPEEGEVVADRPFRRGFLTNITNPKMLLFSLAFLPQFIGSGDPTPQLAMLAVVFLALAAVWEGTIVLAASAVGGRLRKPGVTTALDVVCAAVFATMSVGLVI
>CP029607|6972638:7023370|7022158_7023370_-|AXX33210.1|protease|DBSCAN-SWA
MAFVLGVVLFALLIGISIALHELGHLATAKAFGMKVTRYYIGFGPRVWSMRRGETEYGLKAIPAGGFCEIVGMTALDELSPEDEKRAFYRQKTWKRVVVLSAGSITHFIVGFVVLYAMAATIGLPDIRDEAVVSKVSQCVPATAAEAKKENPTCAPTDPTPGVSAGVQQGDRIVAVDGQRLPTWTEVQKKIQQSSGPTEVVVLRGDDEVKLTVDIPQVERELRRADGSTYVDTVGVVGVAKSRLYEYNALTAVGGATKYTGDMFANTWRGLMKFPEKIPMVIKAIGGGERDPEAPVSVVGASILGGDAVSAGLWHFFWLMLAGLNFFIGVFNLLPLLPLDGGHIAVNLYERVRDWVRKLRGKPAGPPVNYLRLLPLTYFAIFVGGAITLLTITADIVNPIRLP
>CP029607|6972638:7023370|7015029_7016559_-|AXX33204.1|DBSCAN-SWA
MSGAVLVAGTTSDAGKSVLVAGLCRWLAREGVRVAPFKAQNMSNNSAVTPDGGEIGRAQAVQAAACGLEPSVRFNPVLLKPGGDRSSQVVVLGKVAGEVSAMSYRERKAELMTVVLDTLAGLRADHEAVVCEGAGSPAEINLRATDIANMGLARAAGLPVLVVGDIDRGGVLAHLFGTLALLDPADQALVAGFVVNKFRGDPALLEPGLRQLRELTGRPVHGVLPWREELWLDAEDSLSYAADGVIGRPQAPVGRQWLRVAVVRLPRISNATDVEALACEPGVSVRFVTEPSRLADADLVVLPGSKATVSDLAWLRRTGLADAIAAHDGPVLGVCGGYQMLARSIDDPVESGAGPVPGLGLLDVDVVFEPEKALHRPTGVALGEPVTGYEIHHGRVARRADDLPGLVELPGGEVEGAVRGRVVGTHWHGLLENNGFRRAFLRHVAGLAGRDGFEVAPDTDFAARREAQLDLLGDLVVDHLDTGAVRALLERGAPGGLRVVPPAGAPPVA
>CP029607|6972638:7023370|6976370_6977060_+|AXX33170.1|DBSCAN-SWA
MTGADPVWQSTSLLGRVREPARADLLALGTRVPYGPDKEVIVQDARDTHVLLLLSGMVKVQAVDEDGERALLDIRIAGDVVGEMAALSGRPRSATVRTCGDVVARAITRADFQALLLRRPEVAMELVLVVGERLRWSIDRRRDFLSCPAPVRVARVLVELVQTYGRQDKDAWRLGIPLTKVELASIAGMKPRTAEKAFSDLRHAGVVVSNLRRDVLVPDLRALRRYAGS
>CP029607|6972638:7023370|7010823_7012191_-|AXX33201.1|DBSCAN-SWA
MSIQQIPPDRIPVSVHIATDPGDDATVGTHPVTGAADQTTADPTTAAPATAPPAEPAPGPRQGRGAALVGSTLLAVGVALAAANLRPAVTSLASVLGDVRASLGATTAWTSLLTAVPTVCFGVAAFAAPWLGRRFGMARAVGASLVVLTLGLVLRVLDGPAVLLGGTFTACAGIAVCNVLIPVVVKESFPDKVGFLTGVYTAALAAGAAVGAALTPTLETVLGSWQLAAATWALLSTAALLVWSASARHGAAPAPAHGARPAAPARRTSVLRSPLAWVITVFFGLQSLLAYTVMGWLPQIMADSGVDRTTAGMLLAITMVLGVPVSLVVPPLATRWGSQSWLVVLLGSLSIAGILGLAIAPVAAPGLWVVLIGTGMCVFPLALVIISLRTATAADTANLSAMAQSIGYLISAAGPFAFGVLRDVTGAWTVSMYVLAGVLVALIALGVIAGRPRTL
>CP029607|6972638:7023370|6977191_6977911_+|AXX33171.1|DBSCAN-SWA
MSWSPSTTQPEQPVWPHDSLLSRLRDQARDELLAMGTVVRYAPNRDVIVQDARDTHALLLLDGVVKVQTTDETGDTALLAIKAAGDFVGEMAALDRKPRSASVITCGEVTARMISSSELMGFLHRRNEVFVEMIGMVNERLRWAIERRRDFLARAADERLAKVLAELVRTHGREEPGGWTLGFPLTKVELASIAGMKPRTAEKAFSDLRKAGVVVSHLRRDVLVPDLDALRAYAQRPPR
>CP029607|6972638:7023370|6992599_6992719_+|AXX33183.1|DBSCAN-SWA
MPYDGGKGEARAHAAVSFLGCPRPCPVQAIGGRVPDSRF
>CP029607|6972638:7023370|6998632_6999376_-|AXX33191.1|protease|DBSCAN-SWA
MRLAVFLSVLAVLCGGGVATAAAEPRVVGGTRASIAEHPWVVFLAGTTGSQFCGGTLVAPTKVVTAAHCVAGTAPERLVVVAGREDKRTQAGETLRVARIWKHPFYSSAEQGSDVAVLTLARPVANRVLPLASADPAPGTVAKVLGWGRTAEIGAASQVLLGANVPVMSNQDCTADYARFDPAAMVCAGYPRGGIDTCQGDSGGPLVANGALIGVTSWGEGCARPGQPGVYSRITAYRALIDQQLKG
>CP029607|6972638:7023370|7018251_7020051_-|AXX33207.1|DBSCAN-SWA
MVLLPKLAGPVCLLLLLSGCGLFTSEPGPGDALGDFLSKVASGDTLGAAELTDDPASAKDLLDKVRGALGATGLTTSVDAVGDQSGATAPAEATLEWQLPNEHRWKYRTTVELRREADDWKVHWAPSVVHPKLGAQQSLGFAEARPALAPVLDRDGTALMSPETVVSVLLSPKEAGDLNAVATALAGALSRFDGKITAKTVADGAAAVPEGQSYLVAALRDADYQSVKPAIYELPGVRFTSQVSLLAPSRDYGSQVLPAIRKSVEDTVAGEAGFRVYTANSSGQEVETLFDQQPEPAHAVPTTLSRRMQDAAEDALEPIAQPAMLVALKVGTGEVLAVAQNGPADEQGAIALTGQFPPGSTFKIVTAAAAMASGKANADSPLPCPARTTVDGRRIVPNDKEFDKGAVPLRTAFAFSCNTTFAQLAAELPAAALTEQAASFGLGVDFEIPAITTITGSVPEASDVVERAEDGFGQGKVVASPFGMALVAATAAGGAMPTPTLMREQATKADRQPPAPSTAVLEPLRAMMREVVESGTATQLRDLGDVRGKTGTAQYGDGVNSHGWFVGYRGDVAFATLLLGANASTPAVDATGRFLRATG
>CP029607|6972638:7023370|6984677_6985937_-|AXX33177.1|DBSCAN-SWA
MIGLFASTERGRAQAKELAAFLGPDAVVPDGPVAPALRRMWPVLGSAVLFEGSETAIRLVAPLLRDERSDPGVVCVDGAFAIALLGGADALAQRVADVLGRTAVTTAPPTASPLDELLELLDATAEGDAVACGEAMRAGEPVALANPLGFPLPALPDNVLPAGHEAAWTVLLDDRVPRTELGDHVVRVIPRTLVIGIGASAGVTSTDVSGALAKLAADGRLDLRAVRAFATLDRKTEEPGIVDAVEDWGFWHGSTTTPLLGYPGEELAVIPVPNPVELAIGIPSVAEAAALRGAAELSAGGRVEIAAEKVKGARATVAAARVLPRGRLALIGLGPGGADDRTPRAEAELRRASVVVGPPECVDQVRHLLRPGTSVRADGAVRLAEQGVAVALVAPDAGPVVAGPVHADVVRVTGVTGQL
>CP029607|6972638:7023370|6982271_6983489_-|AXX33175.1|DBSCAN-SWA
MHGEQHYLVGLDLAGKRVVVVGGGSVAQRRLPRLVSSGARVELVSPEVTPTVQGVVDSGAVTWHARRYADGDLDGAWYVLACTSDPEVNARITADAEARRVFCVRADVGALGTAVTPASGNHDGLLVGVLASGDHNRSARVRDGVLSALRDGTLADQHDQPAGVALVGGGPGDPDLITVRGRRLLARADVVVADRLGPVWLLDELPPHVEVVDAAKIPYGRAAAQEFINRTLVDNAKAGKFVVRLKGGDPYVFGRGFEELIACAEAGVPVTVVPGVTSAFGVPALAGVPVTHRGVAHEVVVVSGHVAPDDERSLVDWGALARLRGTVVILMGVERAAAFAAALREGRPGDTPVTVVENGSTDAQRIVRSTLDGLAEAVAAHHVRPPAIIVVGPVAGLAGELPEQV
>CP029607|6972638:7023370|7001585_7002251_+|AXX33194.1|DBSCAN-SWA
MTVPDPNQLHPMADHPRVVLLKPLVDAPNIEVGDYTYYDDPERATEFQTRNVLYSYGPERLVIGKYCALGTGTTFIMAGANHLTKGPSTFPFTIFGGAWAEKTADIMAAAPSKGDTVVGNDVWFGCGATVMPGVTIGDGAIIATGAVVTSNVAPYTVVGGNPAQAVRQRYPDDKIELLLRAAWWDWPVELVTEHVREIMAGKVKQLADIAEENGLLKPKPR
>CP029607|6972638:7023370|7007816_7008527_-|AXX33198.1|DBSCAN-SWA
MPPSTTTTSTTTTPPPPPPKLFQQPYRYGTAQKEAPPQEGDLAPVVSSIETDKPYVFLTVDDGAVRHPKALQLVRDSGIEPSLFLNTTHVQPDPAYFKALQGAGAHVHAHTADHPNLRGMGYEAQRAQICGNADYLGSALGTRPTLFRPPFGNYDLNTRRAAASCGMRAVVLWTAAVNDGVVQFQVGDKLRGGDIVLMHFRDSFVADFTAFCERAKADGMTPVLLDDFLAPPTKRH
>CP029607|6972638:7023370|6972638_6974384_-|AXX33167.1|tRNA|DBSCAN-SWA
MITRMSSLFLRTLREDPADAEVPSHKLLVRAGYVRRVAPGGYSWLPLGLRVLRNIERVVREEMDAIGAQEIQFPALLPKEPYEATNRWTEYGPNIFRLKDRKGADYLLGPTHEELFALTVKGEYSSYKDYPVALYQIQTKYRDEARPRAGILRGREFVMKDSYSFDLTDDGLAEAYQRHRAAYIKIFDRLGMDYVIVSATSGAMGGSASEEFLAVAPNGEDTFVRSTESDYAANVEAVTTPAPPAQPVEGRPEAQVHSTPATPTIDTLVEFFNNAGLGREFTAADTLKNVLVKTRVPGSDWELLAIGLPGDREVDLKRLEAAVEPAEVAMLDEADFKAHPFLVKGYIGPGALLANEVRYLVDPRVVEGTAWVTGADQHEHHVVDLLCGRDFTPDGTIDVAEVREGDPSPDGKGVLVAARGIEIGHIFQLGRKYADAFSLDALGPDGKPVRITMGSYGIGVSRLVAAIAEQSHDDRGLIWPRNVAPADVHVVVAGKDATLLEGGEKLAGELSSAGLSVLLDDRKASPGVKFADAELVGVPTILVVGRGLASGLVEVKDRRSGERVEVPVDEAVQHVLAVARG
>CP029607|6972638:7023370|7000659_7001589_+|AXX33193.1|DBSCAN-SWA
MLGDGFEVRTLPLGSEASAALVRRRADGAAERGAVLYVHGFADYFFQRHVAEHFASLGYDFYALDLRAHGRSLRPGEVANHVEDLSTHFEELDAAVRVVREEDGHRGLVVIGHSTGGLTTSLWAHERRQDGALDALVLNSPWLDLAEPWVMRTVGTAVVRGVGRVAPKLVLKPGLGPVYGESIHRDHHGEWEFDTAWKPIEAFPVTAGWLRAVRVGHARLHRGLDVRVPVLVLHSARSHLKARRWSAEAMTADAVLDVEHMRRWAPGIGRDVSLVQVDGGMHDLFLSAAPVRERALAEVGAFLERKVER
>CP029607|6972638:7023370|6988463_6989861_-|AXX33180.1|DBSCAN-SWA
MSALVVAAPASGSGKTTVATGLMAALRRAGDAVAPFKVGPDYIDPGYHALATGRPGRNLDPVMVGEHRVPELFAHGARGADLAVVEGVMGLFDGRIDTDGVGSTAHVAKLLGAPVLFVVDARGQSRSLAALLHGFRGYDPGVRLGGVVLNQVGSPRHEQVLRSACADVGLDVLGVLPRDDRFALPSRHLGLVTAAEHGHEAVAAVEAVADAVGAHVDLAAIRALAATANPVAARAWDPDAEIAAVVESSSAPRVPVGSRPVIAVAGGPAFTFGYAEHPELLRAAGADVVVFDPLRDETLPANTSGLLLPGGFPEQHAAELSANEPLRATITALARAGAPVHAECGGLLYLAKSLDGAPMCGVVDSEAAMTPRLVLGYRDAVAPVDSVLLPVGARVTGHEFHRTALSIPHGADPAWRWRGHDGRPAAEGFVLGNVHASYLHTHPASIPESAHRFTAACAAWEHPPA
>CP029607|6972638:7023370|7017334_7018192_-|AXX33206.1|DBSCAN-SWA
MSVRAVLKPGTQSPRRPVPEHIERPEYVDRPAPQRNTDPWAQTPEVIEAMRVAGRLAAQALQEAGKAVVPGVTTDRLDAIAHEFLCDHGAYPSTLGYRGFPKSCCTSLNEVICHGIPDSTVVEDGDIVNIDVTAFIGGVHGDTNATFIAGEASEEVRLLVERTHEATMRAIKAVKPGRQLNVVGRVIEAYANRFGYGVVRDFTGHGIGRTFHNGLIVLHYDAPHVPTVIETGMTFTIEPMITLGGADGEMWDDGWTVTTKDKSWTAQFEHTLVVTDEGAEILTTC
>CP029607|6972638:7023370|7020973_7022131_-|AXX33209.1|DBSCAN-SWA
MTDGVMLGMPALPPPVLSERRRTRQLKVGSVGVGSESPVSVQSMTTTVTADVNATLQQIAELTASGCDIVRVACPTQDDADALAAIAKKSQIPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKKFDDKVKEIAAAARDHNTPIRIGVNAGSLDPRLMAKHGKATPEALAESALWEASLFAEHDFHDLKISVKHNDPVVMVRAYEILAEQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLRQGIGDTIRVSLSAPPVEEVKVGNQILQSLNLRPRKLEIVSCPSCGRAQVDVYTLAEQVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGKVIKTVPEHLIVETLIEEAMRIAEEVGETEASGEPVVTVG
>CP029607|6972638:7023370|6995704_6996157_-|AXX33187.1|DBSCAN-SWA
MTQHHPATLRRQWAADLTATQLYALLKLRVDVFVVEQNCPYPELDGRDLEPGTRHLWLEEDGEPQAYLRLLEEPGGVFRVGRVVTARTARGKGFSRRLMVAAMAEIGDAEAVLDGQTYVVDFYASFGFAPEGEEFIEDGIPHLRMRRPRR
>CP029607|6972638:7023370|6999544_7000579_-|AXX33192.1|protease|DBSCAN-SWA
MSEEIERSTSRVRFPGISPRAYEHPVDRGALAVLRAVPGIGPVLKSVAGAFTERGERLGYLATSIRVGPKQYPALDRLRNETAATLDLDPVPELFISRNPQPNAMALGIDKPFIVLTTGLVELLDHDGLRFAIGHEMGHVLSGHALYQTILMRLMQLQHSLGWMPAGYWAVRAVIAALHEWYRKTELSCDRAGLLCAQDPAAALRVHVALAGGMDLTQVDTAEFLKQAKEYEQVEDVRDSVLKLIRTWPLTHPMAVVRAAELQRWAASEEYRAILSGDYRRREDDHASSTFTDDLKEAARSYKSDAAESEDPLMKVVNDLGGVVADAAGKVRGRFSGFGSPSGS
>CP029607|6972638:7023370|6994575_6995754_+|AXX33186.1|DBSCAN-SWA
MTEHTGESVFDWIDARAEARAEAGLTRRVRPRAASGGALDLAGNDYLGLARDKRVVGAAAAASMRWGAGSTGSRLVTGSTELHTELEYELANFCGAQAALVFSSGYAANLGALTALSGPGTAIVADQHIHASLIDGCKLSRADVVVAGHRDLPQVTRALSTRGERRGLVVTDSVFSVDGDTAPLAELAAVCREHGAGLVVDDAHGLGVVGDGGRGAVHAAGLAKSPDVVTTVTLSKALGAQGGAVLGPGRVIRHLVDTARTFIFDTGLAPGSAAAALASLKALKEEPERPERVREAARRLSERLRERGFRASEPSAAVVSVLAPSPEVAVAWAEACRERGVLVGCFRPPSVPDQVSRLRLTARADLSEADLARAVEVIAEAGASAGAGSRPR
>CP029607|6972638:7023370|6978428_6979589_+|AXX33172.1|DBSCAN-SWA
MREHAITTNALHELKINFNHGGRVDDAACADTRYGGTDGVDTDADADADDYAGHADADGYDADGHDEGGGDDSDADPYGRWSDYELDDYGPREVRTRVRVVRDDEENVRRGRLTEEAKKRLGESRQLTGPEDGDRWSTWGSADQGPAPHPAWLVTDLGAVDRELGLIKSGKEADVSLLERATPERSCLLAAKRYRDNDHRLFHRDAGYLEGRRERRSREARAMSRRSAFGRNLIAERWAVAEFAALGALWQRGVPVPYPVQRDGTEVLMEFIGDGAQAAPRLAQTRPEPDALVDLWRQLGSALTGMAAAGYAHGDLSPYNLVVHDDRLVVIDLPQLVDLVANPRGAEFLARDVRVVADWFTARGLPAELADPAELTADLLREAGLG
>CP029607|6972638:7023370|6987159_6988272_-|AXX33179.1|DBSCAN-SWA
MGAGPGAADLITLRGARRLAEADVVVWAPSVVEVECVREHARPGAELVDFSRVTESEVVEVYRRAAASGQAVVRLHAGDPATWGGLREQHDACLRLGLEIEVVPGVTQVSAAAASVGRELTTSEVAQSLLLASPESAEHVRELAAHGTTLALSASAARADRVAEQLRAGGYADTTPVVIAYKVSLPDAVLVRTTLGELESAVKEHKLYRSTLFLVGDALRAPVRRGAPIGDEPVRQPRASKWRAARAPGAESRSEAAWSAVHDLQETARSRWARAREESGADGVELPVARSLAEPGGPAEITESAESGPVAEALAVDALPGQAGSPEQEPSEPRKKPPVAAARKRTVSVQASTTPRKPAPARGKKPKRTG
>CP029607|6972638:7023370|6992893_6993787_-|AXX33184.1|DBSCAN-SWA
MTTFSASDLPDLTGRTAVVTGANSGIGRVTARVLAARGARVVLAVRSTAKGREAASTMPGSTEVRELDLADLASVRAFADGFGDQVDLLVNNAGLMTPPLNRTADGFESQFGTNHLGHFALTNLLLPRITGRVVTVSSGAHRAGKIDFADLNWERKPYRAMAAYGQSKLANLLFSAELQRRLTAVGSPVLATSAHPGLAATNLFRPQGGDNPLNRLVNAGVRAVGQTDEGGAQATLHAALATVPGNAFSGPSGALGKGAPKLVGRSKAAQDAELARRLWTVSEELTGVTFPLPLKSA
>CP029607|6972638:7023370|6980314_6980566_-|AXX33173.1|DBSCAN-SWA
MVGNGGSEGRVHVLRTAVALAGALAGPARGLRALGTALGHGWQNIPPGHGTSRGLLCTRGQARSRGRARRFVAPTVGWSTGWS
>CP029607|6972638:7023370|7020068_7020899_-|AXX33208.1|DBSCAN-SWA
MLDDRELTGVLAALAADPVASCMVAARVESVGLDPWRLGGEVWSFDHRSLRGGRVDALCFAGPNLIPLSGGQAALRGFADRARRRGRTCSSLVGPAEQVIGLWEELERDWGPAREVRADQPLLAMGGAPSVRPDPLVRPVRPAELERYLPAAIAMFVEEVGVDPCVEDGGAGYRARVAELIASGRAFARFENGEVVFKAEIGAMSRQVGQIQGVWVRPDRRGHGVGAAGTAAVADRLVRGLGRTASLYVNGYNSPARAAYRKIGFTQVGQYATVLF
>CP029607|6972638:7023370|6975071_6975968_+|AXX33169.1|DBSCAN-SWA
MSGGAGVRRRRCPAARVSGVSGVSGVTAWSGGDGWFRWVGSPVVLVLLPPSETKATGGSGAPLDLDALSHRELNPVRDKLVTALVDLAADVPASLAALGLSERQAGEVGRNAELRASATTPALRRYTGVLYDALDVPSLTKAERDRAFARIGVVSALFGLVGGGDAIPAYRLSGGSALPATGPLGALWRPALTPVLAEADEFVVDLRSGPYASLAKAPAAVVVRVVSDDGSGRRKAVSHFNKAHKGLLARALVRSRTEPSTVAGLVKVAASAGLTLEETGAKTLDLVITGNPADKPAA
>CP029607|6972638:7023370|6990571_6992638_-|AXX33182.1|DBSCAN-SWA
MGARFPFSAVVGHDDLRLALLLNAVHPGVGGVLVRGEKGTAKSTVVRALAALLPDLAVVPGCRFGCEPGVDADCPDGPHGGGPHPGGPHPTGAPGTDPAAEHRPARLVELPVGATEDRLIGSLDLERALTEGVRAYQPGLLAAAHRGVLYVDEVNLLQDHLVDLLLDAAAMGRAHVEREGVSVSHPASFLLVGTMNPEEGELRPQLLDRFGLTVAVKAARDVPTRAEVIRRRLAYEADPAGFARAWESEDAALAARIARARAALPSVALPDAELRRIAGICAAFEVDGMRADLVVARAATAHAAWRGAEAVQEQDVEAAVRLALPHRKRRDPFDEPGMEEEQLSEAMRQGAEHAQDETDDTDDTDGPDDDPDGPGDGGPDDGGQGPDQPQGPQEPGGEQPEPSNQDGKPNGSGGTRAHTPSPAFRTRLLQVPGVGEGASGKRSRARSRSGRAVRPSTTEGSGLHLVATLAAAAPHQATRGRTGPGLLLRGEDLRKAVREGTEGNLVLFVVDASGSMAARQRMSAVSGAVISLLRDAYQRRDKVGVITFRGSEAETALPPTTSVDAAAARLRALRTGGRTPLADGLLRARRVLQSEKVRDPRRRPLLVLLTDGRATATGAGGDPVRDALRAAGLLAADRVASVVVDCESGHVRLGMAARVAAALDGACLRLEELSADQVAGVVRAARAA
>CP029607|6972638:7023370|7002325_7004683_-|AXX33195.1|protease|DBSCAN-SWA
MGDTLALPVLPLDDTVVLPGMVVPVRLTGSDAGAEARAAVEAATSAAGGVNGARVLLVPRLDGRYAKVGALATVEQVGRLAGGERAAVLRATERVRIGTGTTGPGAALWVEATVVEEPPPDERARSLARDYRAVVTTILQQRGAWQVVDSVRQVDGPSALADLAGYAPYLENDQKVWLLETGDVGDRLERLLEWGRAHLAELDVAESIAKDVKEGVEKQQREFLLRQQLAAIRKELAELDGKPATEEQDYRARVEAAELPEKVREAALREVDKLERTSEQSPEVGWIRTWLDTVLDLPWGERTEDSYDIAGARAVLDADHAGLDDVKERITEYLAVRRRRADRGMGLVGGRGGGAVLALVGPPGVGKTSLGESVARAMGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRIARAISEAGSMNPVVLLDEIDKVGADHRGDPTAALLEVLDPAQNHTFRDHYLEVELDLSDVVFLATANVLESIPGPLLDRMELVRLDGYTEDEKVTIARDHLLPRQVERAGLEPGDVEVTGAALRRLAGEYTREAGVRQLERSLARVLRKVTAGVALDRAELPVTVDGGDLEGYLKSPKFTPESAERTAVPGVATGLAVTGAGGDVLFVEAALAEPGTGAGGVVLTGQLGEVMKESAQIALSYLRAHDERAATLDGRGVHVHVPAGAVPKDGPSAGVTMVSALASLLSGRPVRSDVAMTGEVSLTGRVLPIGGVKQKLLAAHRAGITTVLLPARNGPDLEEVPRDVRDALTVHLVGDVREVLELALEPEAVAAAA
>CP029607|6972638:7023370|7005733_7007677_-|AXX33197.1|DBSCAN-SWA
MMAAGDGDYGDYEDFDRCCDLTMRGGATSGIVYPLAVVELSKHYRFRSLGGASAGAIGASFAAAAERGRDSGGFDRLADTVTWFASGRQRLAQLFQPTRATRKLYRLVTATMQSRETTGRSAAVSLVFALLGAIGPRAKAALAAALLVWLAGPALWFGAVAWPGFPTWGLAAIVVVAAVTVPWVAVKALPTGRGPLPARIGLLLLAAVPLYPIVPRLRVDWAVLASAATAGVVWLVLGFGLASAVVLIYAGGVRRFVRERAVSIGFGLVPGTGGYRASWWDRRCGMPKSTDVPPLSDWLADSLDHLSGVRGLRFSDLTTNLVLMSTDVSEGRPCRLPFTSDDRWLFCADCLAGVLPARVVDLLGDEGADDKRCPLHPATALRVLPADLPVALAVRMSMPMPGLISAVPLVRAEPEPRVHWFSDGGITSNFPIHFFDTLLPRWPTFGLTLQGYPAPGVQDVWLPEQDASQEGRPWRSVTGAVGFAQAVLDTALGWRDAMQSALPGFRGRIAHVRLRGGEGGTNLFMRPETIRALAERGRVAGELLRTRFTQEGGERTARYRWIRMRIAMREYQELARQARERGEQYRELADGYPVPEELKSWFADPPAGTDPFSADVRLTLDQLGGLVPGPFDGAPPVNPDLRLNPAE
>CP029607|6972638:7023370|6996254_6997004_-|AXX33188.1|DBSCAN-SWA
MRISARLVAALALVAVQLASQLVAAPAALAVVGGSVAGRAPWVAALLDARGSQFCGGALIAPDRVVTAAHCTQERGLLGPRDRAPRQLTVVLDRHDLRTRSGVRVGVSGIWRHPAFTDVGRGDDLAVLQLDGPVAFEPVRVGDAVAGRTATAYGWGRTAESGPVSSLLRQVDVPIRTDHDCAAALAGYRADAMLCAGFPDGGRDACTGDSGGPLVSDGLLVGVVSYGRGCARAGQPGAYTRLAHYRDRL
>CP029607|6972638:7023370|6986306_6987155_-|AXX33178.1|DBSCAN-SWA
MDVPALHRFLTDTGRTWSAVVVVDAAEHGLAHARNVCLARSSVLVANADPAALAKGLAGWRRTLVVPGPSGPSTADPAEVALRSWPEPLPVLCLAEQPLLPDASRWALPDDEFSHRGDGLVATAEVRALVLAKLGPRPGALVWDVAAGPGAVAVECARLGAAVVAVERDPVQCVRIIANASAHHVDVRVVESDVELAPRDLPRPDAVFVGGGGPGAVRACAGLGARRVVVATTRLDAVLPSHDALRDGGYAVSGTQLSAARLEDDHLRAVDPVTVLWAEHPA
>CP029607|6972638:7023370|6989857_6990472_-|AXX33181.1|DBSCAN-SWA
MPQGQPTAVPSDGLTTRQRRNRPLLLVHTGPMKGKSTAAFGLALRGWNQGWDIGVFQFVKSAKWKVGEEAAFRALGELHESTGQGGPVQWHKMGEGWSWSRKAGTEEDHAAAALEGWREIARRIADQRHGLYVLDEFTYPLKWGWIDVDEVVEVLVGRPGHQHVVITGRDAPQALVDAADLVVEMTKVKHPMDAGQKGQRGIEW
>CP029607|6972638:7023370|6983803_6984589_-|AXX33176.1|protease|DBSCAN-SWA
MAKTLRRLAKFIGLGVAAAAIGLMTTPVSSASDVTPFIVGGTRASISEAPWTVYLASSSGSQFCGGTLVKANKVVTAAHCVAGRSASSTRVVIGREDKQSTAGTVATVSGIWSHPSYRTATSGYDVAVLTLGTSVSGTYLPLATPSDTALYAAGTNAVAYGWGATCSGCSTSRYLLKVTVPVTSDATCKTAYSQYSNTSMVCAGVPAGGKDTCQGDSGGPLVAGGKLIGATSWGNGCALPNYPGVYARVAAYYSVLSAQIG
>CP029607|6972638:7023370|6974571_6974934_+|AXX33168.1|DBSCAN-SWA
MPGMGLSYGMTTVDAADPRGLAAFWAGALETDAVQEYGDDGDLVMLTAEGGVRLGFQRVAEPTPGKNRVHLDFGAADLAAEVERLTGLGAVLVAERSMPGVEWVVLADPAGNQFCVSKAG
>CP029607|6972638:7023370|7016605_7017313_+|AXX33205.1|DBSCAN-SWA
MVDTPATAVLLHSPFLGPASLAPLADALAALGRPVLPLDVRVTVNAAPVHQRIIGGLTDAVEDSGVSGDLVLIGHSGAGPLLPAFAEALEEAPVTGLVYLDSDLPTPGRSWRDTAPAELFSALKAASRGGLLQRWDRWFGPDGIADLVSDADLLAEITAEAPEVPLAFLKEPHPTIEWTGPQALLRLSPAYDEACAQAAALGWPVRELDLHHLAAATDPEPVALALADLLDRLGR
>CP029607|6972638:7023370|6997805_6998531_-|AXX33190.1|protease|DBSCAN-SWA
MAMALALLLTGVAVAPPAGADPRIVGGVVVDAPNPYPWVVALADQNGRQFCGGAIVSRYQVVTAAHCVNGLTGRDVLVVAGRLDVTKPGGTVHPVSQVYVHSAYRSATSGADIAYLLTSTPMPYEPIALAKPSETGLYRAGITGTAFGWGRTSESGSTSPVLRKVSVPLQTNEVCAAAYPGYYQSSSMFCAGLPNGGKDACQGDSGGPFIIAGRLAGLVSWGVGCARPEYPGVYTRVGVYT
>CP029607|6972638:7023370|7009316_7010699_+|AXX33200.1|DBSCAN-SWA
MRHFDLVVIGTGSGNSIVDEAFAAWDVAIVEKGVFGGTCLNVGCIPTKMFVHTADLAAGPASAARFGVDASLDGVRWTDVRDRIFGRVDPIAEGGRRWRESGSANTTVFSGTARFTGPKTLDTGAGETITADRFVIAAGSRPVVPDVPGLAETGFHTSDTVMRLDRLPRRMVILGSGFVATEFAHVFSSFGVEVTLVARSGALLRAEDDAVSARFTELASAKWDVRLDRRAVRAERVDGVARLHLEGPDGPEVVEAEELLVAVGRQPNTDLLDVAATGVALNDKGRVAVDEFQRTSVEGIYALGDISSDYQLKHVANHEAKVVRHNLLNPDAPVASDHRFVPSAVFSSPQIASVGLTERDAVAKGVSYVSVEQPYASIAYGWAMEDTTGFVKLLADPVTGQLLGAHVIGPQAPTVVQPLIQAMSFGLDARSMAKGQYWIHPGMPEVVENALLALPLKDQR
>CP029607|6972638:7023370|7008747_7009275_+|AXX33199.1|DBSCAN-SWA
MSLDRPVAPDPYSLLPTVPAFQVTSTDVADGRPLPQAQVFEGGNTSPQLSWSGFPEGTKSFVVTCFDPDAPTPSGFWHWVAVNLPVSTTSLDTGAGADDASLPGGAFHVRSDYGTRAFGGAAPPQGDHPHRYFFVVHAVDVEALDVDGDASPAVVSFNLAFHTLARAIITPTYQH
>CP029607|6972638:7023370|6980530_6981943_+|AXX33174.1|DBSCAN-SWA
MDAPLASTVPDHVESTLPEGPLPSFSELGLADELVRALATAGITEPFPIQAATLPDSLAGRDLLGRGQTGSGKTLAFGLALLSRLAGGRAKPHMPRALVLVPTRELAMQVEEALSPFARALGLWCRTVVGGTSFPRQIDALRRGVDLLIATPGRLSDHVRQGTADLSEVMFTALDEADQMADMGFMPQVRAILDLTPENGQRLLFSATLDGDVDKLVRQYLHDPVVHSVAPPTGSVTTMEHHLLFVSAEDKQSVVTEVAAREGRTIMFVRTKHHVDRLAKKLRSMGVHAGALHGGKAQSARTRVLGQFREGTTPVLIATDVAARGIHVDDVSLVVHVDPPADPKDYLHRAGRTARAGQSGTVVTLVTHDQRRAVQGLTSRAGIRPESTKVRPGDDELIRITGAREPSGVPVVEPEVQPRGRRGGAGGGAGARRGGGGFFRGGREGGRGEGGGRDRDRAGGRPRRSAAPQH
>CP029607|6972638:7023370|7004854_7005655_+|AXX33196.1|DBSCAN-SWA
MEQASWVPASVDLDRPSTARMYDYYLGGSHNFAVDREAAKAVEHVFPGMSGAARSLRTFLRRSVRYLLDQGIDQFLDLGSGIPTVGNVHEIAQAANPAARVVYVDIEPVAVAHSTAILSANPLATAIQADLRDPASVLENEDVRRLLDFDRPIGVLMVAVLHFVPDSDDPHGAIARYRDALVPGSFLAISHATVEGVQVDAEQDTARVQDVYKRTESPLIFRDRAEVAKLFDGFEVVEPGVVPLSEWRRDSDDAYTSAYVGVGRKV
>CP029607|6972638:7023370|7014149_7015022_+|AXX33203.1|DBSCAN-SWA
MLVAAIWGVNFVVVKVGLAEFPPLLFSALRFLLAAVPAVFFLGGPRVAWRWVFGVGLALGVVKFGLLFTGMHAGMPAGLSSLVLQSQVVFTVALSAVVLGERPRPAQVLGLAVATTGFVVIALDYRVSSPVSALLLVVGGALAWGVANVLTRKAQPPDSLRFIVWVSAVAVLPLLALSLLVEGPEADLAALRGMDWAGAGSLLFVAWVSTLLGFALWGFLLRTYPAPRVVPFALLVPVAGMLSGWLLLDEEVTAVRLGAAGLVVAGMGAATLTRPRSRRHAEPVVEAVPV
>CP029607|6972638:7023370|7013133_7014048_-|AXX33202.1|DBSCAN-SWA
MLDLGRLRALHAVARHGSVGAAASALGYTPSAVSQQITKLERETRAVLLERRGRGVVLTDAALLLADTAERVLALVEGAEVALERQRGQVVGELRIGAFSTAARGLLPPALAELAVRHPELDARLVEQDPPEAIGAVARGELDLAVAHDWVNAPLPVHESLARVRLGEDYADVLLPPGHRLAGRAAVGVADLAGERWICQPEGTICHDWLVNAFRAEGAEPLLAHRVGEYETQLALLERGVGVALLPRLGRGVLPEGVRAVPFEPRPTRRVFVVWRAQAARRPAIGAVAQVLREVWEAWVPTRG
>CP029607|6972638:7023370|6993848_6994499_+|AXX33185.1|DBSCAN-SWA
MTVDDRPYHHGRLREALLDAAWRSVREHGAEQLSLRELAREVGVSHAAPRRHFPDRQALLDALAIAGFERMDVELRTAVAGAGVDYRDRLVAATRAYFRFAVDDPALLELMYTGKHRPGADAVVAAVAAPLGLLEAMLAEGRERGELGDGDPERIGVLMFATVHGLAAMVKGRMVDREVAGGLVDDAVVRFLTGGVPSAAGAPGAAGGALWTCPRP

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AXX33167.1|6972638_6974384_-|tRNA	Prolyl-tRNA synthetase	NA	NA	NA	NA
AXX33168.1|6974571_6974934_+	glyoxalase family protein	NA	NA	NA	NA
AXX33169.1|6975071_6975968_+	UPF0246 protein YaaA	NA	NA	NA	NA
AXX33170.1|6976370_6977060_+	transcriptional regulator with cyclic nucleotide-binding domain	NA	NA	NA	NA
AXX33171.1|6977191_6977911_+	transcriptional regulator with cyclic nucleotide-binding domain	NA	NA	NA	NA
AXX33172.1|6978428_6979589_+	serine/threonine protein kinase	NA	NA	NA	NA
AXX33173.1|6980314_6980566_-	hypothetical protein	NA	NA	NA	NA
AXX33174.1|6980530_6981943_+	ATP-dependent RNA helicase	Q5GF26	Diachasmimorpha_longicaudata_entomopoxvirus	3.5e-41	28.3
AXX33175.1|6982271_6983489_-	Siroheme synthase / Precorrin-2 oxidase	NA	NA	NA	NA
AXX33176.1|6983803_6984589_-|protease	secreted trypsin-like serine protease	Q0ZP54	Neodiprion_abietis_NPV	5.3e-23	33.5
AXX33177.1|6984677_6985937_-	Cobalamin biosynthesis protein CbiG / Cobalt-precorrin-3b C17-methyltransferase	NA	NA	NA	NA
AXX33178.1|6986306_6987155_-	Cobalt-precorrin-6y C5-methyltransferase	NA	NA	NA	NA
AXX33179.1|6987159_6988272_-	Cobalt-precorrin-4 C11-methyltransferase	NA	NA	NA	NA
AXX33180.1|6988463_6989861_-	Cobyrinic acid A,C-diamide synthase	NA	NA	NA	NA
AXX33181.1|6989857_6990472_-	Cob(I)alamin adenosyltransferase	NA	NA	NA	NA
AXX33182.1|6990571_6992638_-	ChlI component of cobalt chelatase	NA	NA	NA	NA
AXX33183.1|6992599_6992719_+	hypothetical protein	NA	NA	NA	NA
AXX33184.1|6992893_6993787_-	putative oxidoreductase/Short-chain dehydrogenase	NA	NA	NA	NA
AXX33185.1|6993848_6994499_+	Transcriptional regulator, TetR family	NA	NA	NA	NA
AXX33186.1|6994575_6995754_+	8-amino-7-oxononanoate synthase	NA	NA	NA	NA
AXX33187.1|6995704_6996157_-	ElaA protein	NA	NA	NA	NA
AXX33188.1|6996254_6997004_-	Trypsin-1 precursor	Q0ZP54	Neodiprion_abietis_NPV	6.9e-20	31.9
AXX33189.1|6997171_6997786_+	Putative threonine efflux protein	NA	NA	NA	NA
AXX33190.1|6997805_6998531_-|protease	secreted trypsin-like serine protease	Q6JKF3	Neodiprion_sertifer_nucleopolyhedrovirus	4.3e-27	35.7
AXX33191.1|6998632_6999376_-|protease	secreted trypsin-like serine protease	I6WTR7	Cotesia_sesamiae_Mombasa_bracovirus	2.9e-18	31.1
AXX33192.1|6999544_7000579_-|protease	Zn-dependent protease with chaperone function	NA	NA	NA	NA
AXX33193.1|7000659_7001589_+	Lysophospholipase	NA	NA	NA	NA
AXX33194.1|7001585_7002251_+	acetyltransferase	A0A2R8FE91	Brazilian_cedratvirus	2.3e-19	41.6
AXX33195.1|7002325_7004683_-|protease	ATP-dependent protease La	A0A0R6PGP8	Moraxella_phage	5.9e-134	44.0
AXX33196.1|7004854_7005655_+	hypothetical protein	NA	NA	NA	NA
AXX33197.1|7005733_7007677_-	RpoH suppressor	NA	NA	NA	NA
AXX33198.1|7007816_7008527_-	secreted protein	NA	NA	NA	NA
AXX33199.1|7008747_7009275_+	PEBP family protein	NA	NA	NA	NA
AXX33200.1|7009316_7010699_+	NADPH-dependent mycothiol reductase Mtr	A0A2K5B2C5	Erysipelothrix_phage	1.0e-40	26.7
AXX33201.1|7010823_7012191_-	putative integral membrane transporter	NA	NA	NA	NA
AXX33202.1|7013133_7014048_-	LysR-family transcriptional regulator	NA	NA	NA	NA
AXX33203.1|7014149_7015022_+	Permease of the drug/metabolite transporter (DMT) superfamily	NA	NA	NA	NA
AXX33204.1|7015029_7016559_-	Cobyric acid synthase	NA	NA	NA	NA
AXX33205.1|7016605_7017313_+	hypothetical protein	NA	NA	NA	NA
AXX33206.1|7017334_7018192_-	Methionine aminopeptidase	NA	NA	NA	NA
AXX33207.1|7018251_7020051_-	Cell division protein FtsI	NA	NA	NA	NA
AXX33208.1|7020068_7020899_-	GCN5-related N-acetyltransferase	NA	NA	NA	NA
AXX33209.1|7020973_7022131_-	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase	NA	NA	NA	NA
AXX33210.1|7022158_7023370_-|protease	Intramembrane protease RasP/YluC, implicated in cell division based on FtsL cleavage	NA	NA	NA	NA