CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
AP018400	Streptococcus ruminantium GUT187T DNA, complete genome	1 crisprs	PrimPol,RT,csa3,csn2,cas2,cas1,cas9,DinG,cas3,DEDDh	0	5	7	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: AP018400_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018400_1

1322514-1323143

TypeII

Consensus_repeat	Method
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CRISPRCasFinder
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	CRT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	PILER-CR

9 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of AP018400_1

>merge|AP018400|1|1322514-1323143|CRISPRCasFinder,CRT,PILER-CR
AGGGGACTGTTACTTAAATCTTGAGAGTACAAAAACTCTCCTTTGTATTTGATTTGATTATAGTATGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTCGCTCTGATGCACCACTACTATCCCAGTAGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTGTTCTGTTACTGTAAGTGTTTCGTACATAGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTATCCCAATAGCACAAAATAATGCAATGTTGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACAGATCGGCTGAATTATCTATCTCTTGCTAAGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTAATGCCGATAGTTTCTGAAAAGCAAAAACGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACTGGCAAGTTCAATGCTCTGCTTCATTAAGTGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACGGTGTTTTTGGCCTATTTTGGGGTGTTTTTGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAACAATTTGAGGTGGATAAATGAGAGAAGGAACGTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>AP018400|1|1|1322514-1323143|CRISPRCasFinder
AGGGGACTGTTACTTAAATCTTGAGAGTACAAAAAC	TCTCCTTTGTATTTGATTTGATTATAGTAT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TCGCTCTGATGCACCACTACTATCCCAGTA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGTTCTGTTACTGTAAGTGTTTCGTACATA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TATCCCAATAGCACAAAATAATGCAATGTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AGATCGGCTGAATTATCTATCTCTTGCTAA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TAATGCCGATAGTTTCTGAAAAGCAAAAAC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGGCAAGTTCAATGCTCTGCTTCATTAAGT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GGTGTTTTTGGCCTATTTTGGGGTGTTTTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AATTTGAGGTGGATAAATGAGAGAAGGAAC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>AP018400|1|1|1322514-1323143|CRT
AGGGGACTGTTACTTAAATCTTGAGAGTACAAAAAC	TCTCCTTTGTATTTGATTTGATTATAGTAT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TCGCTCTGATGCACCACTACTATCCCAGTA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGTTCTGTTACTGTAAGTGTTTCGTACATA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TATCCCAATAGCACAAAATAATGCAATGTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AGATCGGCTGAATTATCTATCTCTTGCTAA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TAATGCCGATAGTTTCTGAAAAGCAAAAAC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGGCAAGTTCAATGCTCTGCTTCATTAAGT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GGTGTTTTTGGCCTATTTTGGGGTGTTTTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AATTTGAGGTGGATAAATGAGAGAAGGAAC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

>AP018400|1|1|1322580-1323143|PILER-CR
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TCGCTCTGATGCACCACTACTATCCCAGTA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGTTCTGTTACTGTAAGTGTTTCGTACATA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TATCCCAATAGCACAAAATAATGCAATGTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AGATCGGCTGAATTATCTATCTCTTGCTAA
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TAATGCCGATAGTTTCTGAAAAGCAAAAAC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	TGGCAAGTTCAATGCTCTGCTTCATTAAGT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	GGTGTTTTTGGCCTATTTTGGGGTGTTTTT
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC	AATTTGAGGTGGATAAATGAGAGAAGGAAC
GTTTTACTGTTACTTAAATCTTGAGAGTACAAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
AP018400.1\|BBA92889.1\|1319493_1320648_-\|UDP-N-acetylglucosamine-2-epimerase	unknown	unknown	gnl\|CDD\|274654
AP018400.1\|BBA92893.1\|1324567_1325443_-\|type-II-CRISPR-associated-endonuclease	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|274694
AP018400.1\|BBA92892.1\|1324247_1324526_-\|CRISPR-associated-endonuclease	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
AP018400.1\|BBA92890.1\|1320660_1321677_-\|N-acetylneuraminate-synthase	unknown	unknown	gnl\|CDD\|274655
AP018400.1\|BBA92896.1\|1330736_1331333_-\|LemA-family-protein	unknown	unknown	gnl\|CDD\|377192
AP018400.1\|BBA92886.1\|1316170_1317322_+\|5-methyltetrahydropteroyltriglutamate---homocysteine-methyltransferase	unknown	unknown	gnl\|CDD\|239427
AP018400.1\|BBA92899.1\|1333984_1334818_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|369777
AP018400.1\|BBA92895.1\|1329176_1330553_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase	unknown	unknown	gnl\|CDD\|235392
AP018400.1\|BBA92885.1\|1314802_1315972_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340897
AP018400.1\|BBA92887.1\|1317628_1318801_-\|acylneuraminate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|133006
AP018400.1\|BBA92894.1\|1325645_1329020_-\|type-II-CRISPR-RNA-guided-endonuclease	cas9	cd09643_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|273840
AP018400.1\|BBA92883.1\|1313564_1314431_-\|tRNA-dimethylallyltransferase	unknown	unknown	gnl\|CDD\|234626
AP018400.1\|BBA92897.1\|1331410_1332214_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224429
AP018400.1\|BBA92882.1\|1312321_1313572_-\|GTPase-HflX	unknown	unknown	gnl\|CDD\|274455
AP018400.1\|BBA92884.1\|1314517_1314688_+\|DUF3042-domain-containing-protein	unknown	unknown	gnl\|CDD\|371431
AP018400.1\|BBA92900.1\|1334891_1336436_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|223562
AP018400.1\|BBA92891.1\|1323204_1324251_-\|hypothetical-protein	csn2	cd12217_csn2_CAS-II-A	gnl\|CDD\|213410
AP018400.1\|BBA92888.1\|1318870_1319497_-\|NeuD-protein	unknown	unknown	gnl\|CDD\|100050
AP018400.1\|BBA92881.1\|1311708_1312338_-\|cystathionine-beta-lyase	unknown	unknown	gnl\|CDD\|235382
AP018400.1\|BBA92898.1\|1332487_1333888_-\|dipeptidase-PepV	unknown	unknown	gnl\|CDD\|235988

Protein	Function_ID	Function_description	E-value
AP018400.1\|BBA92889.1\|1319493_1320648_-\|UDP-N-acetylglucosamine-2-epimerase	gnl\|CDD\|274654	TIGR03568, Polysialic_acid_biosynthesis_protein_P7, UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing. This family of enzymes catalyzes the combined epimerization and UDP-hydrolysis of UDP-N-acetylglucosamine to N-acetylmannosamine. This is in contrast to the related enzyme WecB (TIGR00236) which retains the UDP moiety. NeuC acts in concert with NeuA and NeuB to synthesize CMP-N5-acetyl-neuraminate.	1.62211e-169
AP018400.1\|BBA92893.1\|1324567_1325443_-\|type-II-CRISPR-associated-endonuclease	gnl\|CDD\|274694	TIGR03639, cas1_NMENI, CRISPR-associated endonuclease Cas1, subtype II/NMENI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is a prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 variant of the NMENI subtype of CRISPR/Cas system.	7.58588e-118
AP018400.1\|BBA92892.1\|1324247_1324526_-\|CRISPR-associated-endonuclease	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	1.30348e-19
AP018400.1\|BBA92890.1\|1320660_1321677_-\|N-acetylneuraminate-synthase	gnl\|CDD\|274655	TIGR03569, ORF_8_similar_to_NeuB_family, N-acetylneuraminate synthase. This family is a subset of the pfam03102 and is believed to include only authentic NeuB N-acetylneuraminate (sialic acid) synthase enzymes. The majority of the genes identified by this model are observed adjacent to both the NeuA and NeuC genes which together effect the biosynthesis of CMP-N-acetylneuraminate from UDP-N-acetylglucosamine.	0
AP018400.1\|BBA92896.1\|1330736_1331333_-\|LemA-family-protein	gnl\|CDD\|377192	pfam04011, LemA, LemA family. The members of this family are related to the LemA protein. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular. The exact molecular function of this protein is uncertain.	1.28429e-65
AP018400.1\|BBA92886.1\|1316170_1317322_+\|5-methyltetrahydropteroyltriglutamate---homocysteine-methyltransferase	gnl\|CDD\|239427	cd03311, CIMS_C_terminal_like, CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by transferring a methyl group from 5-methyltetrahydrofolate to L-homocysteine without using an intermediate methyl carrier. The active enzyme has a dual (beta-alpha)8-barrel structure, and this model covers the C-terminal barrel, and a few single-barrel sequences most similar to the C-terminal barrel. It is assumed that the homologous N-terminal barrel has evolved from the C-terminus via gene duplication and has subsequently lost binding sites, and it seems as if the two barrels forming the active enzyme may sometimes reside on different polypeptides. The C-terminal domain incorporates the Zinc ion, which binds and activates homocysteine. Sidechains from both barrels contribute to the binding of the folate substrate.	8.83825e-77
AP018400.1\|BBA92899.1\|1333984_1334818_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	8.89517e-18
AP018400.1\|BBA92895.1\|1329176_1330553_+\|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
AP018400.1\|BBA92885.1\|1314802_1315972_-\|MFS-transporter	gnl\|CDD\|340897	cd17339, MFS_NIMT_CynX_like, 2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.23512e-92
AP018400.1\|BBA92887.1\|1317628_1318801_-\|acylneuraminate-cytidylyltransferase	gnl\|CDD\|133006	cd02513, CMP-NeuAc_Synthase, CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety. CMP-N-acetylneuraminic acid synthetase (CMP-NeuAc synthetase) or acylneuraminate cytidylyltransferase catalyzes the transfer the CMP moiety of CTP to the anomeric hydroxyl group of NeuAc in the presence of Mg++. It is the second to last step in the sialylation of the oligosaccharide component of glycoconjugates by providing the activated sugar-nucleotide cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), the substrate for sialyltransferases. Eukaryotic CMP-NeuAc synthetases are predominantly located in the nucleus. The activated CMP-Neu5Ac diffuses from the nucleus into the cytoplasm.	2.25848e-58
AP018400.1\|BBA92894.1\|1325645_1329020_-\|type-II-CRISPR-RNA-guided-endonuclease	gnl\|CDD\|273840	TIGR01865, conserved_hypothetical_protein, CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.	0
AP018400.1\|BBA92883.1\|1313564_1314431_-\|tRNA-dimethylallyltransferase	gnl\|CDD\|234626	PRK00091, miaA, tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed.	6.86105e-128
AP018400.1\|BBA92897.1\|1331410_1332214_-\|hypothetical-protein	gnl\|CDD\|224429	COG1512, COG1512, Beta-propeller domains of methanol dehydrogenase type [General function prediction only].	5.17012e-26
AP018400.1\|BBA92882.1\|1312321_1313572_-\|GTPase-HflX	gnl\|CDD\|274455	TIGR03156, GTP_HflX, GTP-binding protein HflX. This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like). [Unknown function, General].	0
AP018400.1\|BBA92884.1\|1314517_1314688_+\|DUF3042-domain-containing-protein	gnl\|CDD\|371431	pfam11240, DUF3042, Protein of unknown function (DUF3042). This family of proteins with unknown function appears to be restricted to Firmicutes.	1.26797e-18
AP018400.1\|BBA92900.1\|1334891_1336436_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	0
AP018400.1\|BBA92891.1\|1323204_1324251_-\|hypothetical-protein	gnl\|CDD\|213410	cd12217, Stu0660_Csn2, Stu0660-like CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. This family of Csn2 proteins includes Stu0660, the proteins are larger than other (canonical) Csn2 proteins as they have an additional alpha-helical C-terminal domain. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	1.77024e-121
AP018400.1\|BBA92888.1\|1318870_1319497_-\|NeuD-protein	gnl\|CDD\|100050	cd03360, LbH_AT_putative, Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity. A few members are identified as NeuD, a sialic acid (Sia) O-acetyltransferase that is required for Sia synthesis and surface polysaccharide sialylation.	8.67962e-56
AP018400.1\|BBA92881.1\|1311708_1312338_-\|cystathionine-beta-lyase	gnl\|CDD\|235382	PRK05270, PRK05270, UDP-glucose--hexose-1-phosphate uridylyltransferase.	2.03827e-10
AP018400.1\|BBA92898.1\|1332487_1333888_-\|dipeptidase-PepV	gnl\|CDD\|235988	PRK07318, PRK07318, dipeptidase PepV; Reviewed.	0

>AP018400.1|BBA92890.1|1320660_1321677_-|N-acetylneuraminate-synthase
MVYIIAEIGCNHNGDVHLAKKMVDVAVQCGVDAVKFQTFKAEKLISKYAPKAEYQKETTGEKDSQLEMTRRLELSFDEYLELRDYCLSKHVDVFSTPFDEESLDFLISTNMPVYKIPSGEITNLPYLEKIGKQGKKVILSTGMAAIEEIHRAVGILRENGTTDISILHCTTEYPAPYRSLHLNVLTTLKKEFPNASIGYSDHSIGSEVPIAAVALGASIIEKHFTLDNAMEGPDHRASATPEVLSDLVKGVRIIEQALGRSEKIPDPVEEKNKIVARKSIVAKKDIKKGDIFSVDNITVKRPGDGISPMKWYDILGKVSEADFEVDQNIIHSDFANQL
>AP018400.1|BBA92889.1|1319493_1320648_-|UDP-N-acetylglucosamine-2-epimerase
MKKICFVTGSRAEYGIMRRLLTRLDQDEDIQLDLVVTAMHLEEKYGYTLTDIERDGFTITKKIYLQLTDTSKATIAHSLATLTDGLIDVFSSEQYDLVIILGDRYEMLPVANVALIFTVPICHIHGGEKTLGNFDESIRHAITKMSHLHLTSTEEFRKRVIQLGESPQRVKHIGSMGVENVLLQDFLSKEELSCLLNIELEENYYVVLFHPVTLENQTAVSQTEALVEALKKTGTQCIVIGSNSDTSSDAIMQVLHSFVEENVSRHLFSSLPTKYFHSLVKHSKGLLGNSSSGLIEVPSLRVPTLNIGNRQLGRVSGPSVCHVGTRTADIVSGLDALEKISDFTNPYEKADSSFLAYSAIKEFLTAGDVVMKDFYDLKCDEEII
>AP018400.1|BBA92888.1|1318870_1319497_-|NeuD-protein
MKKVAFLGAGTFSDGVLPFLDLTMYEFVGYFDDKPIKEYRRYPILGKLSESVSFLEKGLIDCVFITIGDNEKRKEVFELVAENHYSAIVNIISPHSNVFSKDSIKGRGIFLGFSSFIGSESVVYDNCIINTGAIIEHHSVIGPHCNIAPGSTVNGLCQIGEGTYVGSGAVIIQCISIHPFTTIGAGCVVVRNILESGTYVGVPAKKIK
>AP018400.1|BBA92887.1|1317628_1318801_-|acylneuraminate-cytidylyltransferase
MLFLDGKPMIFHTIHAAIESGCFKKENIFVSTDSEHYKKICETTGVSVLMRPKELATEFATSYQVNKHFLEPFPEDQVFVLLQVTSPLRTGRHIQEAFALYLNGEADHVVSFTKVDKSPTLFTTLDEGSYIKDSVGLGKNYRRQDEKLLYYPNGAIYISSKNAYLRDETYFSEKTQAYLMKKEDSVDVDDRFDFMAVIGRIYFDYQKREKKNSRFYAEKIEKLVHKQSQDNIILGDSRLLNLSLEGFDNLSIGGITFNTLLDNIDQLLTKKLHTVIISLGINDFIVGYDLETIEHNVDRLFNILNDHCQSLYVTTIAYSLFRDGVNNEDVKKINEFILDKTEKMGLYCIDLNETMAEEGHLKYEYTSDGIHYNESGQEVVNRMIGLSTCI
>AP018400.1|BBA92886.1|1316170_1317322_+|5-methyltetrahydropteroyltriglutamate---homocysteine-methyltransferase
MTTSRFQLVGSLLRPSNLKEFKRKIEYRDDIQYPFYDAFDGYQETETAAIEAIIAEQKANGIDVITDGEFSKSMWHLDFIWGFQGIKRYIAEHGYPFKDHNGQIFETRKDIGLSITGPLSAKNHHFIDIYKTVNKLAGNSDTKLTVWGPAHAFTELVLFNGQVGADKIYKTREDLKEGLLAAYKEFLVEYKEAGGSIIQFDDCLWELFDPANPVPFLPQDDSEALAALADEFISINNTIIDYGHEIGLTVWTHNCRGNYESRAAANGTYEAIAEKFLRDQKYDRFFLEWDDERAGDLKALESLRDKDVEVVLGLLSSKTSDLDDEKRVYKLLEEASKIIPKDRLYLSHQCGFASCDSGNELAIPQQWNKIKQGQDIAATFWSE
>AP018400.1|BBA92885.1|1314802_1315972_-|MFS-transporter
MMKKQSPFMVAGIVMLGVVMRAPFTALPAILTDVAVGLGVEVSSLGILTSIPLIMFALCSSLAPRLAAKFGMEKLMAIVLLVMVVGSGMRVLNLPALYVGTMLIGATIAFINVLLPSLVAANFPQKIGLYTTVYITLMGVAATFASMVAVPIVSASSWEFFIYLISGLVLLAFLIWLPNIQQNHTFASDSQEEKVVSIWKNKAALAFLIFAGLQSVLYYTEITWLPTIAQSVGFSKAEAGLMAGLFNMTAIPMSMIIPAILSRQTRVTRRNSMLAISAVTLLGLFMMAFIPTNLFLWSALHIILSFSNGALFPYMMLSFSLKTSNSQATAQLSGMVQTGGYLIAALGPGLLGYSFPIFGSWLPLMIALAIVTLAMMWTIVLIEKKDIIL
>AP018400.1|BBA92884.1|1314517_1314688_+|DUF3042-domain-containing-protein
MAKGFGKGFLTGVLSTVALAAGAIFTVHKTIIEPEEKKEAFIEENRKKAARKRVAH
>AP018400.1|BBA92883.1|1313564_1314431_-|tRNA-dimethylallyltransferase
MVVGPTAVGKTALGIELAQRYNGEIISGDSQQVYRKLDIGTAKASLEEQAAAVHHLIDVRDVAEGYSVYEFVKEAKMLIADIVSRGKLPIIVGGTGLYIQSLLEGYHLGGQVNQEEVLAYRKELALFSDEILVTMAEQAGLSVQDSSRRRMVRGLELKKFGKNLENTESDYEPIYICLTDDRQVLYDRINQRVDKMMAQGLLEEVTWLYQNYPTSQAAMGIGYKEIFPYLAGECSLDEALDKVKQNSRRFAKRQLTWFRNRMHVPFYSVGCSHYKDTIFTAVEEFLDD
>AP018400.1|BBA92882.1|1312321_1313572_-|GTPase-HflX
MIETQKDQERVLLVGVELQQTDNFEMSMEELASLAKTAGALVKGVYTQKREKYDSKTFVGSGKLDEIAQMVRADEIDMVIVNHRLTPRQNINLEDVLGVKVIDRMQLILDIFAMRARSHEGKLQVHLAQLKYMLPRLIGQGIMLSRQAGGIGSRGPGESQLELNRRSIRNQIHDIERQLKIVEKNRATVRERRLQSGVFKIGLIGYTNAGKSTIMNAMTDKRQYEADELFATLDATTKQINLSGKFNVTLTDTVGFIQDLPTELISAFKSTLEESINVDLLLHVIDASDPNHSEQERVVLDILKDLDMLDIPRLALYNKLDKTDDHFTPSQFPHVMLSAKAENAKRHIQMMVLAKIKTMFEPFEVRVPLTQAYQLHDLSALALIDKRSYEDDVEVVSGYIASTNKWKLEELYDRLP
>AP018400.1|BBA92881.1|1311708_1312338_-|cystathionine-beta-lyase
MIDYLDLALKYGGFTSLDKVYLDRKLAGLTDQQKLDFITPPPSVVNAYFAEMYQKRGAKQATDYFFNLSLELGLIQENPSFAEEKPFIRLNLSGKSFGFSYVRTDGLSQIFSEHEEEVTDSLLFEIAQIFPHYVIFVENGKIFMQYNAFDDNQLMEQETDYLLTQVASSTSLVKLSGLNQDEIMEVAEIYSGRQYFAWSGRSAVLYIEI
>AP018400.1|BBA92891.1|1323204_1324251_-|hypothetical-protein
MNLFFTHHTLGRIPIHFGQFTQIVGQNQELKYYIWQLLIWYLDGKKYREEDLTLFQQAEPEIFLDETVLKRNAFQIISISDVRDIVEQMSYKKGTIGFSYLSSKIQCIEIMEELETINHHLQKTAQKVSANIDLVIDDTCYEVGNMDVTPEQIVTKQLVPYFKKKFDSIAFEFVPNENKLWFLLQMMDYLLEKQTKPILLVFKNMDDYLGYSSFTRIAQHLEVLCRKYPYFHVMIFPSQEGYLYLNESTIETVNILADQIEHYPALEFLYERYKVSYPSNNPLDKQEFLTSLRKVSSYLFCSEISEVVSLSYRDLLTLKIINTLYQYDTKPKFEKYSLSVLEENYLNT
>AP018400.1|BBA92892.1|1324247_1324526_-|CRISPR-associated-endonuclease
METAQEKRQYRLFRKELIANGFEMLQFSVYYRTCPNRSFASKFYKKLQQSYLPAGNVRLLAVTEKQFSEMVLIVGGKTKQEETVSDKKLVII
>AP018400.1|BBA92893.1|1324567_1325443_-|type-II-CRISPR-associated-endonuclease
MRLKLDNLVIKKQGEEFTVPLSDISIIVAEGGDTVVTLRLLSTLSKYNIALIVCDNQHLPTGIYHSQNGHFRAYKKLQAQLAWSQQQKDRLWQIITYFKIGNQQDVLAMLEKDLGTIQLLADYRDHIELGDKTNREGHAAKVYFNELFGKKFVRLTQQETDTINAGLNYGYAIFRAQLARIVADYGLNALIGIFHKNEYNQFNLVDDLMEPFRQIVDVWVYYHLKEADFLTYEHRLELTNLLNAKVRYGKENCSVTVAMDKFVKGFIRCIEDKETNQFFCPIVSSLEMEKS
>AP018400.1|BBA92894.1|1325645_1329020_-|type-II-CRISPR-RNA-guided-endonuclease
MSNGKILGLDIGIASVGVGIIEAQTGEVVHASSRIFPSANAANNAERRDFRKSRRLVRRKKHRIKRLEDLFATYQVELKGELSSENPYILRVKGLSPKLTVDELYVALKNIMKRRGISYLDDAEADSEAGQTDYAKAIERNRKLLDNKTPGEIQLDRLEKYGQLRGNFTIIDDEGQPQQIINVFSTSDYAKEVKQILECQKAYHTFISDDFCDNMLHLLTGKRKYYIGPGNEKSRTDYGVYRTDGTTLENLFGILIGKCTFYEDQYRSSKASYTAQEFNFLNDLNNLTVPTETKKLSQDQKECLVEYAKHTTTLGAKKVLQQVAKLVGCEVDDIKGYRLDNKDKPDMHTFEVFRAMKGLVPLVDIEDLSREQLDVLADILTLNTDFEGIQEALDRQLPDLFNHEQVKELASFRKAKSQLFARGWHSLSQKMMLELIPELYATSEEQMTILTRLGKFQKNDEEKGNTNTIKVDEVVEEIYNPVVAKSIRQTIKIINAATKKWGEFDQIVIEMPRDRNEDEEKKRIADGQKANAKEKVDSIKRAAELYCNGKELPDHLYHGHKQLATKIRLWYQQGERCIYTGQPISIHDLIHNQNQYEIDHILPLSLTFDDSLSNKVLVLATANQEKGQRTPYRYLQSTTAAWSYREFKDYVNKCRGLGKKKREYLIFEEDIDVFEVKSKFIQRNLVDTRYASRVILNALQDYYKTSGKSTKVSVVRGQFTSQLRRKWGIEKTRETYHHHAIDALIIAASSQLKLWKKQENPLLIDYQKGQQIDLETGEILELTDEQYKELVYQPPYQGFVRTISSPGFEDEILFSYQIDSKVNRKLSDATIYATRKAQLGKDKVEETYVLGKIKDIYTQAGYEAFSRRYHKDKTSFLMYQKDPDTWEKVIEIILRDYREFDDKGKEVGNPFERYYKENGYIKKYSRKGNGPAIKSLKYYDNKLGNHINITPENSRNAVVLQSLKPWRTDVYFNLESGKYELLGLKYSDLSFKKGTGEYGISQKKYDSLKKEEGVDKCSKFKFTLYKQDLLFIKDIRNGTDKIFRFSSKNDTNKHYMELKPFEKSKFCADEQLLPILGTVAKSGQCIKGLNKSDISLYKIRTDVLGFKYFIKQEGDQPQLNFKNK
>AP018400.1|BBA92895.1|1329176_1330553_+|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase
MMITKEFDTIAAISTPLGEGAIGIVRLSGTDAFTIASKVFKGKDLATVPSHTLNYGHIIDPANGQVLDEVMLGVMRSPRTFTREDVIEINTHGGIAITNEILQLLIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDVIRAKTDKAMYNAVRQLDGSLSQLINDTRQEILNTLAQVEVNIDYPEYDDVEEATTELIREKTLQFQMLLEQLLSTARRGKILREGIATAIIGRPNVGKSSLLNNLLREEKAIVTNIEGTTRDIIEEYVNINGVPLKLIDTAGIRETDDIVERIGVERSKKALEEADLILLVLNAAEPLTEQDRKLLAISNLANRIILLNKTDLEEKIEADQLPNDVIRISVLKNQNITQIEEKINQLFFENAGLVEQDATYLSNSRHISLIEQAVQSLQAVNDGLEMGMPVDLLQVDLTRCWQILGEITGDAAPDELITQLFSQFCLGK
>AP018400.1|BBA92896.1|1330736_1331333_-|LemA-family-protein
MRGFEMNKKWLIILIPVLALLFLGMGAIGQYNGLVDSYAEVENAQANVNTQLQRRYDLIPNVVSAVKGAMKHEEKIFIAIADARAKIGSSKQGSAEYNQAQGQLDSAVSRLLVVAENYPQLTANQQVSNLITELEGTENRLLVARKDYNAVATTYNKKIRRFPTSIYANIFGYKKVELFQASNDATTTVPSVDLGDKE
>AP018400.1|BBA92897.1|1331410_1332214_-|hypothetical-protein
MFIEGGVLMRKWKNNIIGYLIILIISFSFAPKLVSADLIPEKPIDTTVVDETKLLSTETIATIDQLNRSWAATEQRLQVGVYMKEQLSSDIESLANETFRRWQIGFSGTNNGILLVIAIADRAFRIETSDNAAIVLPDIVAKKILDNAREFFRQKDYNGGVSYIVQSIGDRFYGTSDAKNQLAALEKHNSSEGDGFSIFLVVIFVAIILFVIDKSGRGGGGTGSLLWMLVNDHQHYRNNHSSSSSSSDFGGGWSGGGGGGGGASSGW
>AP018400.1|BBA92898.1|1332487_1333888_-|dipeptidase-PepV
MTVNFRTEVDKRKDEFMADLFDLLRINSERDDSQADAKHPFGPGPVHALNKFLEIADRDGYPTTNVDNYAGHFEFGEGDEVLGIFGHLDVVPAGSGWDTDPYEPQIIDGKLFARGSSDDKGPTMACYYGLKIIKELGLPTSKKVRFIVGTDEESGWADMDYYFEHVGLPLPDFGFSPDAEFPIINGEKGNITAYLHFTGENSGAARLHSFAGGLRENMVPESATAIISGDLTDLDSKLAAFVEEYGLKADAEALDNGRVQVTVIGKSAHGSTPEEGVNGATYLAKFLGQFAFDGAAKAYLELAGDTLLEDHEAKKLGVAISDEQMGALSMNAGVFKFDEASSDNTIALNFRYPKNTNPETIKAGLEKLGVEAVSLSEQGHTPHYCPIDDPMVATLLSVYEKHTGLKGYEQVIGGGTFGRLLKRGVAYGAMFPGDVNTMHQANEFIEVEQLYRAAAIYAEAIYELIK
>AP018400.1|BBA92899.1|1333984_1334818_-|class-I-SAM-dependent-methyltransferase
MNNKKDEVVFAQTSLEEHKMSDYVSYNQDRWDRISSKQGNSYTVPISHEEFLRVKNSFLEVSLTVGKMVPLEWFEKARGKKLLGLACGGGQQGPIFAAHGYNTTIMDFSQEQLAKDRLVAERENIDLQAVQADMTNPFPFEDESFDIIFCPVSNVYIEDLTNMWQESYRVLKKGGLLMVGYMNPWIYVFDGDDVWDDLDKPLEPKYSLPFNSRRLEAAGELAINPKYGYEFSHTLEEQIGGQLKAGFAMIDFYESKDSRNRLTQFGTDYLANLSIKR
>AP018400.1|BBA92900.1|1334891_1336436_-|ABC-transporter-ATP-binding-protein
MSILEVKNLSHGFGDRAIFENVSFRLLKGEHIGLVGANGEGKSTFMSIVTGQLQPDEGKVEWSRYVTAGYLDQHAKLEKGQTVRDVLRTAFDELFKTEARINDIYLSMAEEGADIDDLMEEVGELQDRLESRDFYILDAKIDEVARALGVMDYGMDTDVTELSGGQRTKVLLAKLLLEKPDILLLDEPTNYLDAEHIDWLKRYLQNYENAFVLISHDIPFLNDVINIVYHVENQLLTRYTGDYYQFQEVHAMKRAQLEAAYERQQKEIADLQDFVNRNKARVATRNMAMSRQKKLDKMEIIELQAEKPKPNFDFKMARTPSRFIFQTTDLAIGYDRVLNSKPLNLTFERNQKIAIIGANGIGKSTLLKSLLGIISPLGGSVERGEYLELGYFEQEVAGGNRQTPLEAVWDAFPALNQAEVRAALARCGLTSKHIESQIQVLSGGEQAKVRFCLLMNRENNVLVLDEPTNHLDVDAKDELKRALQDYKGSILMVCHEPDFYQDWVDDIWDFNVLT

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
AP018400_1	1.3\|1322682\|30\|AP018400\|CRISPRCasFinder,CRT,PILER-CR	1322682-1322711	30	NZ_CP015757	Clostridium estertheticum subsp. estertheticum strain DSM 8809 plasmid pDSM8809, complete sequence	2478-2507	6	0.8
AP018400_1	1.7\|1322946\|30\|AP018400\|CRISPRCasFinder,CRT,PILER-CR	1322946-1322975	30	NZ_CP041133	Serratia marcescens strain WVU-009 plasmid pWVU-009, complete sequence	17779-17808	6	0.8
AP018400_1	1.9\|1323078\|30\|AP018400\|CRISPRCasFinder,CRT,PILER-CR	1323078-1323107	30	AP013580	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C16-MedDCM-OCT-S43-C44, * SEQUENCING IN PROGRESS *	25543-25572	6	0.8
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP054833	Staphylococcus saprophyticus strain UTI-045 plasmid pUTI-045-2, complete sequence	7226-7255	7	0.767
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP054442	Staphylococcus saprophyticus strain UTI-058y plasmid pUTI-058y-2, complete sequence	3693-3722	7	0.767
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP014058	Staphylococcus saprophyticus strain FDAARGOS_137 plasmid unnamed, complete sequence	5328-5357	7	0.767
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP014114	Staphylococcus saprophyticus strain FDAARGOS_168 plasmid unnamed1, complete sequence	9096-9125	7	0.767
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NC_016643	Staphylococcus saprophyticus subsp. saprophyticus plasmid pSSAP2, complete sequence	3693-3722	7	0.767
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP054435	Staphylococcus saprophyticus strain UTI-035 plasmid pUTI-035-1, complete sequence	3693-3722	7	0.767
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP022057	Staphylococcus saprophyticus strain FDAARGOS_336 plasmid unnamed2, complete sequence	10846-10875	7	0.767
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP054446	Staphylococcus saprophyticus strain UTI-056 plasmid pUTI-056-2, complete sequence	3693-3722	7	0.767
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NC_015432	Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence	28279-28308	7	0.767
AP018400_1	1.4\|1322748\|30\|AP018400\|CRISPRCasFinder,CRT,PILER-CR	1322748-1322777	30	GQ866234	Aggregatibacter actinomycetemcomitans strain D11S-1 plasmid S25, complete sequence	23852-23881	7	0.767
AP018400_1	1.7\|1322946\|30\|AP018400\|CRISPRCasFinder,CRT,PILER-CR	1322946-1322975	30	NZ_CP011920	Burkholderia cenocepacia strain ST32 plasmid pBCEN1232, complete sequence	147384-147413	7	0.767
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP031260	Klebsiella quasipneumoniae strain L22 plasmid pL22-3, complete sequence	46847-46876	8	0.733
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP041077	Bacillus tropicus strain LM1212-W3 plasmid p4, complete sequence	2550-2579	9	0.7
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	AP013707	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C22-MedDCM-OCT-S25-C85, * SEQUENCING IN PROGRESS *	14880-14909	9	0.7
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	AP013718	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C22-MedDCM-OCT-S42-C114, * SEQUENCING IN PROGRESS *	13987-14016	9	0.7
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP024775	Bacillus thuringiensis LM1212 plasmid pLM4, complete sequence	9545-9574	9	0.7
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	NZ_CP020750	Bacillus mycoides strain Gnyt1 plasmid unnamed7, complete sequence	4800-4829	9	0.7
AP018400_1	1.1\|1322550\|30\|AP018400\|CRISPRCasFinder,CRT	1322550-1322579	30	GU943018	Uncultured phage MedDCM-OCT-S04-C136 genomic sequence	11846-11875	9	0.7

1. spacer 1.3|1322682|30|AP018400|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP015757 (Clostridium estertheticum subsp. estertheticum strain DSM 8809 plasmid pDSM8809, complete sequence) position: , mismatch: 6, identity: 0.8

tgttctgttactgtaagtgtttcgtacata	CRISPR spacer
tgttcttttactgtaagtgttttttccttt	Protospacer
****** ***************. * * *

2. spacer 1.7|1322946|30|AP018400|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP041133 (Serratia marcescens strain WVU-009 plasmid pWVU-009, complete sequence) position: , mismatch: 6, identity: 0.8

tggcaagttcaatgctctgcttcattaagt	CRISPR spacer
tggcaagtttaatgctctgcttctctaccg	Protospacer
*********.************* .**

3. spacer 1.9|1323078|30|AP018400|CRISPRCasFinder,CRT,PILER-CR matches to AP013580 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C16-MedDCM-OCT-S43-C44, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.8

aatttgaggtggataaatgagagaaggaac	CRISPR spacer
aagatctggtgcagaaatgagagaaggaac	Protospacer
**  *  **** * ****************

4. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP054833 (Staphylococcus saprophyticus strain UTI-045 plasmid pUTI-045-2, complete sequence) position: , mismatch: 7, identity: 0.767

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ctttttttatatttgattttattatagtag	Protospacer
..*..***.********** *********

5. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP054442 (Staphylococcus saprophyticus strain UTI-058y plasmid pUTI-058y-2, complete sequence) position: , mismatch: 7, identity: 0.767

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ctttttttatatttgattttattatagtag	Protospacer
..*..***.********** *********

6. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP014058 (Staphylococcus saprophyticus strain FDAARGOS_137 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.767

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ctttttttatatttgattttattatagtag	Protospacer
..*..***.********** *********

7. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP014114 (Staphylococcus saprophyticus strain FDAARGOS_168 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ctttttttatatttgattttattatagtag	Protospacer
..*..***.********** *********

8. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NC_016643 (Staphylococcus saprophyticus subsp. saprophyticus plasmid pSSAP2, complete sequence) position: , mismatch: 7, identity: 0.767

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ctttttttatatttgattttattatagtag	Protospacer
..*..***.********** *********

9. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP054435 (Staphylococcus saprophyticus strain UTI-035 plasmid pUTI-035-1, complete sequence) position: , mismatch: 7, identity: 0.767

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ctttttttatatttgattttattatagtag	Protospacer
..*..***.********** *********

10. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP022057 (Staphylococcus saprophyticus strain FDAARGOS_336 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.767

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ctttttttatatttgattttattatagtag	Protospacer
..*..***.********** *********

11. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP054446 (Staphylococcus saprophyticus strain UTI-056 plasmid pUTI-056-2, complete sequence) position: , mismatch: 7, identity: 0.767

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ctttttttatatttgattttattatagtag	Protospacer
..*..***.********** *********

12. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NC_015432 (Staphylococcus saprophyticus subsp. saprophyticus MS1146 plasmid pSSAP1, complete sequence) position: , mismatch: 7, identity: 0.767

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ctttttttttatttgattttattatagtag	Protospacer
..*..*** ********** *********

13. spacer 1.4|1322748|30|AP018400|CRISPRCasFinder,CRT,PILER-CR matches to GQ866234 (Aggregatibacter actinomycetemcomitans strain D11S-1 plasmid S25, complete sequence) position: , mismatch: 7, identity: 0.767

tatcccaatagcacaaaataatgcaatgtt	CRISPR spacer
tttagtaaaagcacaaaaaaatgcaatgta	Protospacer
* *  .** ********* **********

14. spacer 1.7|1322946|30|AP018400|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP011920 (Burkholderia cenocepacia strain ST32 plasmid pBCEN1232, complete sequence) position: , mismatch: 7, identity: 0.767

tggcaagttcaatgctctgcttcattaagt	CRISPR spacer
cggcaagttcaacgctcagcttcattcgaa	Protospacer
.***********.**** ******** ..

15. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP031260 (Klebsiella quasipneumoniae strain L22 plasmid pL22-3, complete sequence) position: , mismatch: 8, identity: 0.733

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ctatttttatatttgatttgattatattct	Protospacer
.. ..***.***************** * *

16. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP041077 (Bacillus tropicus strain LM1212-W3 plasmid p4, complete sequence) position: , mismatch: 9, identity: 0.7

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ccctatttgtattttatttgattataaatc	Protospacer
.*.. ********* ***********.  .

17. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to AP013707 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C22-MedDCM-OCT-S25-C85, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.7

tctcctttgtatttgatttgattatagtat	CRISPR spacer
agcattttgtatttgatttgataataaact	Protospacer
  . .***************** ***.  *

18. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to AP013718 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C22-MedDCM-OCT-S42-C114, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 9, identity: 0.7

tctcctttgtatttgatttgattatagtat	CRISPR spacer
agcattttgtatttgatttgataataaact	Protospacer
  . .***************** ***.  *

19. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP024775 (Bacillus thuringiensis LM1212 plasmid pLM4, complete sequence) position: , mismatch: 9, identity: 0.7

tctcctttgtatttgatttgattatagtat	CRISPR spacer
ccctatttgtattttatttgattataaatc	Protospacer
.*.. ********* ***********.  .

20. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to NZ_CP020750 (Bacillus mycoides strain Gnyt1 plasmid unnamed7, complete sequence) position: , mismatch: 9, identity: 0.7

tctcctttgtatttgatttgattatagtat	CRISPR spacer
agaatgttgtatttgatttgattgtagaag	Protospacer
    . *****************.*** *

21. spacer 1.1|1322550|30|AP018400|CRISPRCasFinder,CRT matches to GU943018 (Uncultured phage MedDCM-OCT-S04-C136 genomic sequence) position: , mismatch: 9, identity: 0.7

tctcctttgtatttgatttgattatagtat	CRISPR spacer
agcattttgtatttgatttgataataaact	Protospacer
  . .***************** ***.  *

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3844 : 57024

Synechococcus_phage(15.38%)

tRNA,bacteriocin

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBA91671.1\|3844_4027_+\|bacteriocin	ComC/BlpC family peptide pheromone/bacteriocin	NA	NA	NA	NA
BBA91672.1\|4056_4221_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
BBA91673.1\|4220_4385_+	hypothetical protein	NA	NA	NA	NA
BBA91674.1\|5098_5380_+	hypothetical protein	NA	NA	NA	NA
BBA91675.1\|5470_6235_+	hypothetical protein	NA	NA	NA	NA
BBA91676.1\|6231_6996_+	hypothetical protein	NA	NA	NA	NA
BBA91677.1\|6999_7710_+	hypothetical protein	NA	NA	NA	NA
BBA91678.1\|7725_8367_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	2.7e-33	38.4
BBA91679.1\|8485_9601_+	redox-regulated ATPase	NA	NA	NA	NA
BBA91680.1\|9754_10324_+\|tRNA	aminoacyl-tRNA hydrolase	NA	NA	NA	NA
BBA91681.1\|10323_13818_+	transcription-repair coupling factor	NA	NA	NA	NA
BBA91682.1\|13868_14141_+	hypothetical protein	NA	NA	NA	NA
BBA91683.1\|14127_14496_+	septum formation initiation protein	NA	NA	NA	NA
BBA91684.1\|14492_14606_+	hypothetical protein	NA	NA	NA	NA
BBA91685.1\|14618_15899_+	serine hydrolase	NA	NA	NA	NA
BBA91686.1\|15899_17168_+\|tRNA	tRNA(Ile)-lysidine synthetase	NA	NA	NA	NA
BBA91687.1\|17175_17718_+	hypoxanthine phosphoribosyltransferase	A0A218MMB5	uncultured_virus	8.5e-12	28.5
BBA91688.1\|17739_19707_+	cell division protein	E5ESM9	Bathycoccus_sp._RCC1105_virus	1.5e-106	47.1
BBA91689.1\|20069_20213_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
BBA91690.1\|27584_28433_+	rod shape-determining protein	NA	NA	NA	NA
BBA91691.1\|28434_28950_+	rod shape-determining protein	NA	NA	NA	NA
BBA91692.1\|28995_30273_+	CHAP domain-containing protein	NA	NA	NA	NA
BBA91693.1\|30529_31498_+	ribose-phosphate pyrophosphokinase	A0A1V0SHF7	Hokovirus	4.1e-41	33.9
BBA91694.1\|31584_32763_+	aromatic amino acid aminotransferase	NA	NA	NA	NA
BBA91695.1\|32749_33532_+	DNA repair protein	NA	NA	NA	NA
BBA91696.1\|33528_34536_+	phosphate acetyltransferase	NA	NA	NA	NA
BBA91697.1\|34528_34777_+	acyl carrier protein	NA	NA	NA	NA
BBA91698.1\|34894_35602_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	8.4e-44	42.2
BBA91699.1\|35617_39343_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	6.4e-34	27.0
BBA91700.1\|39339_40794_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	9.4e-58	34.8
BBA91701.1\|40783_41896_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	4.5e-60	43.6
BBA91702.1\|41892_42447_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	5.8e-24	35.8
BBA91703.1\|42627_44175_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase	Q58MG4	Prochlorococcus_phage	5.0e-73	47.3
BBA91704.1\|44267_45047_+	hypothetical protein	NA	NA	NA	NA
BBA91705.1\|45158_46421_+	phosphoribosylamine--glycine ligase	NA	NA	NA	NA
BBA91706.1\|46737_47226_+	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	7.1e-18	45.7
BBA91707.1\|47212_48286_+	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
BBA91708.1\|48301_49006_+	hypothetical protein	NA	NA	NA	NA
BBA91709.1\|49094_50360_+	adenylosuccinate lyase	A0A1B3B081	Gordonia_phage	2.2e-18	33.2
BBA91710.1\|50677_50821_+	protein phosphatase 1E isoform X2	NA	NA	NA	NA
BBA91711.1\|50873_51062_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
BBA91712.1\|51079_51253_+	hypothetical protein	NA	NA	NA	NA
BBA91713.1\|51271_51454_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
BBA91714.1\|51537_51726_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
BBA91715.1\|51743_51917_+	hypothetical protein	NA	NA	NA	NA
BBA91716.1\|51935_52130_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
BBA91717.1\|52335_52491_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
BBA91718.1\|52545_52737_+	hypothetical protein	NA	NA	NA	NA
BBA91719.1\|52811_52928_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
BBA91720.1\|53002_53149_+	NAD-dependent DNA ligase	NA	NA	NA	NA
BBA91721.1\|53527_55648_+	peptide cleavage/export ABC transporter	W8CYL7	Bacillus_phage	4.0e-41	27.5
BBA91722.1\|55653_57024_+\|bacteriocin	bacteriocin secretion accessory protein	NA	NA	NA	NA

DBSCAN-SWA_2

88558 : 110969

Streptococcus_phage(50.0%)

transposase,tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBA91767.1\|88558_89593_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	7.3e-105	55.8
BBA91768.1\|89647_89815_-\|transposase	ISL3 family transposase	NA	NA	NA	NA
BBA91769.1\|89980_90211_+	cell division protein FtsH	NA	NA	NA	NA
BBA91770.1\|90573_90717_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
BBA91771.1\|97739_98996_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	1.1e-126	55.0
BBA91772.1\|99262_100513_-\|transposase	IS110 family transposase	A0A1X9I619	Streptococcus_phage	8.1e-191	84.2
BBA91773.1\|100612_100996_-\|transposase	IS3 family transposase	A0A0C5AEA5	Paenibacillus_phage	5.1e-11	46.8
BBA91774.1\|101020_101488_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	5.4e-31	50.0
BBA91775.1\|101463_102036_-\|transposase	IS3 family transposase	NA	NA	NA	NA
BBA91776.1\|102078_102765_-\|transposase	ISL3 family transposase	A0A1S5SBP9	Streptococcus_phage	8.4e-65	67.2
BBA91777.1\|103475_103919_+	transcriptional regulator	NA	NA	NA	NA
BBA91778.1\|103919_104624_+	metal ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.8e-06	23.0
BBA91779.1\|104616_105429_+	metal ABC transporter permease	NA	NA	NA	NA
BBA91780.1\|105438_106956_+	zinc ABC transporter substrate-binding protein	NA	NA	NA	NA
BBA91781.1\|107045_107366_+\|transposase	transposase	NA	NA	NA	NA
BBA91782.1\|107362_108247_+\|transposase	transposase	NA	NA	NA	NA
BBA91783.1\|108359_108800_+	CopY/TcrY family copper transport repressor	NA	NA	NA	NA
BBA91784.1\|108774_109011_+	copper chaperone	NA	NA	NA	NA
BBA91785.1\|109251_109653_-	HIT family protein	NA	NA	NA	NA
BBA91786.1\|109712_110969_-\|tRNA	tyrosine--tRNA ligase	K4F5T3	Cronobacter_phage	1.7e-76	40.6

DBSCAN-SWA_3

624041 : 637645

Streptococcus_phage(86.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBA92239.1\|624041_624806_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	5.2e-15	25.7
BBA92240.1\|624811_625516_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	8.7e-17	27.7
BBA92241.1\|625919_626675_+	hypothetical protein	NA	NA	NA	NA
BBA92242.1\|626759_627416_+	CBS domain-containing protein	M1NSC5	Streptococcus_phage	1.3e-110	96.3
BBA92243.1\|627558_627672_+	hypothetical protein	NA	NA	NA	NA
BBA92244.1\|627709_628576_-	YitT family protein	M1Q1P6	Streptococcus_phage	2.0e-140	92.0
BBA92245.1\|628687_629338_+	dTMP kinase	M1PSC7	Streptococcus_phage	2.8e-102	89.6
BBA92246.1\|629337_630222_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	4.9e-126	79.6
BBA92247.1\|630342_630660_+	DNA replication initiation control protein	M1PFV3	Streptococcus_phage	1.2e-53	98.1
BBA92248.1\|630661_631525_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	6.7e-136	85.0
BBA92249.1\|631775_632867_+	3-phosphoserine/phosphohydroxythreonine transaminase	M1Q1P2	Streptococcus_phage	1.4e-194	93.9
BBA92250.1\|632859_633426_+	N-acetyltransferase	M1PSC3	Streptococcus_phage	9.0e-73	66.5
BBA92251.1\|633564_634746_+	phosphoglycerate dehydrogenase	M1NSB9	Streptococcus_phage	2.9e-206	92.1
BBA92252.1\|634745_635237_+	methylated-DNA--[protein]-cysteine S-methyltransferase	M1PFU9	Streptococcus_phage	3.2e-66	72.5
BBA92253.1\|635324_635678_+	arsenate reductase	M1PLC0	Streptococcus_phage	5.3e-55	88.0
BBA92254.1\|635699_636599_-	cation transporter	M1Q1N9	Streptococcus_phage	5.7e-146	87.6
BBA92255.1\|636817_637645_-	exodeoxyribonuclease III	M1PSC0	Streptococcus_phage	1.6e-139	88.3

DBSCAN-SWA_4

880718 : 922628

Serratia_phage(14.29%)

holin,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBA92485.1\|880718_883265_+\|holin	choline trimethylamine-lyase	A0A1S6UAD4	Serratia_phage	5.6e-05	42.6
BBA92486.1\|883338_884325_+\|holin	choline TMA-lyase-activating enzyme	NA	NA	NA	NA
BBA92487.1\|884328_884694_+	BMC domain-containing protein	NA	NA	NA	NA
BBA92488.1\|884690_885137_+	hypothetical protein	NA	NA	NA	NA
BBA92489.1\|885154_886267_+	alcohol dehydrogenase	NA	NA	NA	NA
BBA92490.1\|886317_886926_+	hypothetical protein	NA	NA	NA	NA
BBA92491.1\|886942_887746_+	ethanolamine utilization protein	NA	NA	NA	NA
BBA92492.1\|887755_888055_+	ethanolamine utilization protein	NA	NA	NA	NA
BBA92493.1\|888067_888700_+	ethanolamine utilization protein	NA	NA	NA	NA
BBA92494.1\|888716_889319_+	BMC domain-containing protein	NA	NA	NA	NA
BBA92495.1\|889334_890990_+	acetaldehyde dehydrogenase	A0A1X9I5D4	Streptococcus_phage	4.7e-05	25.0
BBA92496.1\|891001_891712_+	phosphate propanoyltransferase	NA	NA	NA	NA
BBA92497.1\|891725_891998_+	ethanolamine utilization microcompartment protein	NA	NA	NA	NA
BBA92498.1\|892020_892293_+	ethanolamine utilization microcompartment protein	NA	NA	NA	NA
BBA92499.1\|892315_892594_+	ethanolamine utilization microcompartment protein	NA	NA	NA	NA
BBA92500.1\|892704_896334_+	pyruvate:ferredoxin (flavodoxin) oxidoreductase	NA	NA	NA	NA
BBA92501.1\|896570_897368_+	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
BBA92502.1\|897581_899432_-	1,4-alpha-glucan branching protein	NA	NA	NA	NA
BBA92503.1\|899485_900931_-	starch synthase	NA	NA	NA	NA
BBA92504.1\|900939_902055_-	glucose-1-phosphate adenylyltransferase subunit	NA	NA	NA	NA
BBA92505.1\|902067_903195_-	glucose-1-phosphate adenylyltransferase	NA	NA	NA	NA
BBA92506.1\|903934_904123_+	hypothetical protein	NA	NA	NA	NA
BBA92507.1\|904296_905208_-	LysR family transcriptional regulator	A0A2H4J8I9	uncultured_Caudovirales_phage	5.3e-06	27.7
BBA92508.1\|905392_906190_+	dihydroorotate dehydrogenase electron transfer subunit	NA	NA	NA	NA
BBA92509.1\|906199_907135_+	dihydroorotate dehydrogenase	NA	NA	NA	NA
BBA92510.1\|907310_908024_+	orotidine-5'-phosphate decarboxylase	NA	NA	NA	NA
BBA92511.1\|908164_908797_+	orotate phosphoribosyltransferase	Q58MW1	Prochlorococcus_phage	9.0e-05	33.0
BBA92512.1\|908903_909830_+	glycosyltransferase	V9QJB1	Oenococcus_phage	1.3e-73	47.7
BBA92513.1\|909840_910494_+	uracil-DNA glycosylase	A0A2I2L683	Orpheovirus	2.7e-36	44.8
BBA92514.1\|910753_912022_+	dihydroorotase	NA	NA	NA	NA
BBA92515.1\|912270_914361_+	metallophosphatase	NA	NA	NA	NA
BBA92516.1\|915523_915649_+	LytR family transcriptional regulator	NA	NA	NA	NA
BBA92517.1\|915671_916409_+	DNA-binding response regulator	NA	NA	NA	NA
BBA92518.1\|916422_917763_+	GHKL domain-containing protein	NA	NA	NA	NA
BBA92519.1\|917819_917945_-\|bacteriocin	ComC/BlpC family peptide pheromone/bacteriocin	NA	NA	NA	NA
BBA92520.1\|917977_918214_+	hypothetical protein	NA	NA	NA	NA
BBA92521.1\|918470_918782_+\|bacteriocin	bacteriocin immunity protein	NA	NA	NA	NA
BBA92522.1\|919073_919298_+	hypothetical protein	NA	NA	NA	NA
BBA92523.1\|919573_920122_-\|bacteriocin	bacteriocin ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.7e-23	39.9
BBA92524.1\|920208_922317_-	hypothetical protein	NA	NA	NA	NA
BBA92525.1\|922382_922628_-\|bacteriocin	lactococcin 972 family bacteriocin	NA	NA	NA	NA

DBSCAN-SWA_5

1291110 : 1300738

Escherichia_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBA92865.1\|1291110_1294359_-	hypothetical protein	M4ZRP4	Bacillus_phage	2.3e-19	33.8
BBA92866.1\|1294374_1295226_-	dTDP-4-dehydrorhamnose reductase	A0A291LA50	Escherichia_phage	8.6e-27	36.6
BBA92867.1\|1295277_1296354_-	dTDP-glucose 4,6-dehydratase	I7HTA3	Enterobacteria_phage	3.2e-71	44.8
BBA92868.1\|1296406_1296895_-	phosphoribosylanthranilate isomerase	NA	NA	NA	NA
BBA92869.1\|1296894_1297488_-	dTDP-4-dehydrorhamnose 3,5-epimerase	H9NC63	Sphingomonas_phage	3.9e-10	33.1
BBA92870.1\|1297484_1298357_-	glucose-1-phosphate thymidylyltransferase	K7QKA7	Escherichia_phage	4.6e-100	63.2
BBA92871.1\|1298597_1299389_-	Nif3-like dinuclear metal center hexameric protein	NA	NA	NA	NA
BBA92872.1\|1299375_1300062_-	SAM-dependent methyltransferase	NA	NA	NA	NA
BBA92873.1\|1300063_1300738_-	DnaD domain protein	Q938N2	Temperate_phage	1.2e-10	40.8

DBSCAN-SWA_6

1446398 : 1459136

Streptococcus_phage(90.91%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBA93006.1\|1446398_1447094_-	tyrosine protein kinase	A0A1X9I5D6	Streptococcus_phage	1.1e-101	88.4
BBA93007.1\|1447103_1447814_-	capsular biosynthesis protein	A0A1X9I5E1	Streptococcus_phage	4.3e-96	81.7
BBA93008.1\|1447813_1449106_-	LytR family transcriptional regulator	A0A1X9I5X1	Streptococcus_phage	7.8e-181	78.1
BBA93009.1\|1449351_1450095_-	peroxide stress protein	A0A1X9I5I0	Streptococcus_phage	1.6e-85	69.7
BBA93010.1\|1450213_1451485_+	PLP-dependent aminotransferase family protein	A0A1X9I5H2	Streptococcus_phage	3.2e-187	78.0
BBA93011.1\|1451554_1452403_-	DegV domain-containing protein	A0A1X9I5J4	Streptococcus_phage	4.0e-141	90.4
BBA93012.1\|1452707_1453112_+	TetR/AcrR family transcriptional regulator	A0A1X9I6A2	Streptococcus_phage	1.0e-54	85.8
BBA93013.1\|1453359_1454151_-	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	4.0e-111	81.6
BBA93014.1\|1454250_1456797_-	bifunctional DnaQ family exonuclease/ATP-dependent helicase	A0A1X9I5C8	Streptococcus_phage	0.0e+00	75.2
BBA93015.1\|1456962_1457634_+	MBL fold metallo-hydrolase	A0A1X9I5D3	Streptococcus_phage	3.6e-113	88.6
BBA93016.1\|1457593_1457737_+	PolC-type DNA polymerase III	NA	NA	NA	NA
BBA93017.1\|1458101_1459136_-	PhoH family protein	W8D063	Erwinia_phage	5.7e-49	49.1

DBSCAN-SWA_7

1779090 : 1834499

Streptococcus_phage(10.0%)

protease,transposase,tRNA,integrase

attL 1783011:1783063|attR 1792145:1792197

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBA93336.1\|1779090_1779453_-\|transposase	transposase	NA	NA	NA	NA
BBA93337.1\|1779445_1779736_-	hypothetical protein	NA	NA	NA	NA
BBA93338.1\|1779748_1780591_-	hypothetical protein	Q7Y4K5	Streptococcus_phage	2.8e-46	53.6
BBA93339.1\|1780603_1780888_-	DNA-binding protein	NA	NA	NA	NA
BBA93340.1\|1780982_1781531_+	XRE family transcriptional regulator	NA	NA	NA	NA
BBA93341.1\|1781834_1782740_+\|integrase	site-specific integrase	A0A172LN96	Lactococcus_phage	8.5e-33	31.5
1783011:1783063	attL	NA	NA	NA	NA
BBA93342.1\|1783400_1785620_-	type III restriction-modification system, R subunit	NA	NA	NA	NA
BBA93343.1\|1786062_1787745_-	site-specific DNA-methyltransferase	A0A0M7Q8J6	Escherichia_phage	3.6e-93	44.8
BBA93344.1\|1787901_1788609_-	hypothetical protein	NA	NA	NA	NA
BBA93345.1\|1788934_1789837_-	NTPase	NA	NA	NA	NA
BBA93346.1\|1790176_1790491_+	replication protein	NA	NA	NA	NA
BBA93347.1\|1790492_1790756_+	DNA-binding protein	NA	NA	NA	NA
BBA93348.1\|1790770_1791463_+\|integrase	site-specific integrase	NA	NA	NA	NA
BBA93349.1\|1791455_1791593_+\|integrase	site-specific integrase	NA	NA	NA	NA
BBA93350.1\|1791596_1792040_+\|integrase	site-specific integrase	NA	NA	NA	NA
BBA93351.1\|1792146_1792539_-	30S ribosomal protein S9	NA	NA	NA	NA
1792145:1792197	attR	NA	NA	NA	NA
BBA93352.1\|1792558_1793005_-	50S ribosomal protein L13	NA	NA	NA	NA
BBA93353.1\|1793190_1793337_-	hypothetical protein	NA	NA	NA	NA
BBA93354.1\|1793461_1794289_-	DegV family protein	NA	NA	NA	NA
BBA93355.1\|1794321_1794843_-	DNA-binding protein	NA	NA	NA	NA
BBA93356.1\|1794843_1795572_-	23S rRNA (guanosine(2251)-2'-O)-methyltransferase	NA	NA	NA	NA
BBA93357.1\|1795698_1796718_-	hypothetical protein	NA	NA	NA	NA
BBA93358.1\|1796813_1797635_-	endonuclease	NA	NA	NA	NA
BBA93359.1\|1797735_1798737_+	membrane protein	NA	NA	NA	NA
BBA93360.1\|1798768_1799899_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	3.6e-20	32.6
BBA93361.1\|1800014_1800881_-	hypothetical protein	NA	NA	NA	NA
BBA93362.1\|1800882_1801281_-	Mini-ribonuclease 3	NA	NA	NA	NA
BBA93363.1\|1801273_1802641_-\|tRNA	cysteine--tRNA ligase	A0A1V0SAQ2	Catovirus	7.0e-55	30.7
BBA93364.1\|1802627_1802813_-	hypothetical protein	NA	NA	NA	NA
BBA93365.1\|1802806_1803580_-	hypothetical protein	NA	NA	NA	NA
BBA93366.1\|1803598_1804216_-	serine O-acetyltransferase	NA	NA	NA	NA
BBA93367.1\|1804539_1806756_-	polyribonucleotide nucleotidyltransferase	NA	NA	NA	NA
BBA93368.1\|1807038_1807158_-	hypothetical protein	NA	NA	NA	NA
BBA93369.1\|1807382_1808258_-	XRE family transcriptional regulator	NA	NA	NA	NA
BBA93370.1\|1808273_1809797_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.4e-10	20.7
BBA93371.1\|1809855_1810926_-	hypothetical protein	NA	NA	NA	NA
BBA93372.1\|1811693_1811963_-	30S ribosomal protein S15	NA	NA	NA	NA
BBA93373.1\|1811977_1812100_-	hypothetical protein	NA	NA	NA	NA
BBA93374.1\|1812153_1813434_-	uracil permease	Q9KX94	Enterobacteria_phage	1.4e-60	37.9
BBA93375.1\|1813693_1814422_-	rRNA pseudouridine synthase	NA	NA	NA	NA
BBA93376.1\|1814412_1815063_-	N-acetyltransferase	NA	NA	NA	NA
BBA93377.1\|1815112_1816282_-	MFS transporter	NA	NA	NA	NA
BBA93378.1\|1816502_1817117_+	peptide deformylase	E3SLL2	Synechococcus_phage	5.1e-13	38.9
BBA93379.1\|1817728_1817962_-	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
BBA93380.1\|1818037_1819279_-	aminopeptidase	NA	NA	NA	NA
BBA93381.1\|1819446_1820049_-	nitroreductase	NA	NA	NA	NA
BBA93382.1\|1820446_1824838_-	PolC-type DNA polymerase III	A0A0A7RWA3	Clostridium_phage	2.6e-18	32.4
BBA93383.1\|1825271_1825664_-	thioredoxin	NA	NA	NA	NA
BBA93384.1\|1826362_1826506_+	hypothetical protein	NA	NA	NA	NA
BBA93385.1\|1826577_1827567_-	DhaKLM operon coactivator	NA	NA	NA	NA
BBA93386.1\|1827576_1828122_-	dihydroxyacetone kinase transcriptional activator	NA	NA	NA	NA
BBA93387.1\|1828161_1829256_+	dihydroxyacetone kinase subunit	NA	NA	NA	NA
BBA93388.1\|1829293_1829842_+	dihydroxyacetone kinase subunit L	NA	NA	NA	NA
BBA93389.1\|1829838_1830213_+	PTS-dependent dihydroxyacetone kinase phosphotransferase subunit	NA	NA	NA	NA
BBA93390.1\|1830222_1830933_+	aquaporin family protein	M1HJ75	Acanthocystis_turfacea_Chlorella_virus	1.2e-29	35.3
BBA93391.1\|1831103_1832960_-\|tRNA	proline--tRNA ligase	NA	NA	NA	NA
BBA93392.1\|1833239_1834499_-\|protease	RIP metalloprotease	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage