CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP028731	Mycobacterium avium strain HJW chromosome, complete genome	2 crisprs	cas3,csa3,WYL,cas4,RT,DEDDh,DinG	0	2	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP028731_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028731_3

3055844-3055927

Orphan

Consensus_repeat	Method
CGGCCGGCGCCCGAGTTGTCGGCCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028731_3

>merge|CP028731|3|3055844-3055927|CRISPRCasFinder
CGGCCGGCGCCCGAGTTGTCGGCCGGCGCCCGAGTTGTCGGCCGGCGCCCGAGTTGTGTCGGCCGGCGCCCGAGTTGTCGGCCG

>CP028731|3|3|3055844-3055927|CRISPRCasFinder
CGGCCGGCGCCCGAGTTGTCGGCCG	GCGCCCGAGTTGTCGGCCGGCGCCCGAGTTGTGT
CGGCCGGCGCCCGAGTTGTCGGCCG

Protein	Signature genes	Signature genes Name	Protein_function
CP028731.1\|AYJ05838.1\|3051893_3052379_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|273242
CP028731.1\|AYJ05846.1\|3060371_3062048_+\|ABC-transporter-family-substrate-binding-protein	unknown	unknown	gnl\|CDD\|173866
CP028731.1\|AYJ05851.1\|3069020_3070439_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|367155
CP028731.1\|AYJ05832.1\|3046922_3047294_+\|steroid-delta-isomerase	unknown	unknown	gnl\|CDD\|238404
CP028731.1\|AYJ05850.1\|3067367_3068780_-\|IS110-family-transposase	unknown	unknown	gnl\|CDD\|376773
CP028731.1\|AYJ05841.1\|3055451_3055841_+\|hotdog-fold-thioesterase	unknown	unknown	gnl\|CDD\|239527
CP028731.1\|AYJ05843.1\|3056631_3057606_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223674
CP028731.1\|AYJ05844.1\|3057653_3058529_+\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224094
CP028731.1\|AYJ05833.1\|3047387_3049133_+\|potassium-transporter-TrkA	unknown	unknown	gnl\|CDD\|367001
CP028731.1\|AYJ05849.1\|3065969_3067121_-\|exonuclease-SbcCD-subunit-D	unknown	unknown	gnl\|CDD\|223497
CP028731.1\|AYJ05836.1\|3051036_3051450_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319898
CP028731.1\|AYJ05837.1\|3051501_3051897_+\|VOC-family-protein	unknown	unknown	gnl\|CDD\|319939
CP028731.1\|AYJ05847.1\|3062034_3063279_-\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|366166
CP028731.1\|AYJ05840.1\|3054287_3055232_-\|sulfate-adenylyltransferase-subunit-CysD	unknown	unknown	gnl\|CDD\|235375
CP028731.1\|AYJ05834.1\|3049157_3050030_-\|hypothetical-protein	unknown	unknown	unknown
CP028731.1\|AYJ05842.1\|3055991_3056483_-\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|239474
CP028731.1\|AYJ05835.1\|3050091_3050970_-\|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|366009
CP028731.1\|AYJ05845.1\|3058525_3060361_+\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|182342
CP028731.1\|AYJ05839.1\|3052437_3054288_-\|adenylyl-sulfate-kinase	unknown	unknown	gnl\|CDD\|180120
CP028731.1\|AYJ05848.1\|3063342_3065973_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227061

Protein	Function_ID	Function_description	E-value
CP028731.1\|AYJ05838.1\|3051893_3052379_-\|transcriptional-regulator	gnl\|CDD\|273242	TIGR00738, Putative_HTH-type_transcriptional_regulator, Rrf2 family protein. This model represents a superfamily of probable transcriptional regulators. One member, RRF2 of Desulfovibrio vulgaris is an apparent regulatory protein experimentally (MEDLINE:97293189). The N-terminal region appears related to the DNA-binding biotin repressor region of the BirA bifunctional according to results after three rounds of PSI-BLAST with a fairly high stringency. [Unknown function, General].	4.4521e-50
CP028731.1\|AYJ05846.1\|3060371_3062048_+\|ABC-transporter-family-substrate-binding-protein	gnl\|CDD\|173866	cd08501, PBP2_Lpqw, The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold. LpqW is one of key players in synthesis and transport of the unique components of the mycobacterial cell wall which is a complex structure rich in two related lipoglycans, the phosphatidylinositol mannosides (PIMs) and lipoarabinomannans (LAMs). Lpqw is a highly conserved lipoprotein that transport intermediates from a pathway for mature PIMs production into a pathway for LAMs biosynthesis, thus controlling the relative abundance of these two essential components of cell wall. LpqW is thought to have been adapted by the cell-wall biosynthesis machinery of mycobacteria and other closely related pathogens, evolving to play an important role in PIMs/LAMs biosynthesis. Most of periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the LpqW protein. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	5.07776e-162
CP028731.1\|AYJ05851.1\|3069020_3070439_+\|hypothetical-protein	gnl\|CDD\|367155	pfam02720, DUF222, Domain of unknown function (DUF222). This family is often found associated to the N-terminus of the HNH endonuclease domain pfam01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family.	2.64762e-93
CP028731.1\|AYJ05832.1\|3046922_3047294_+\|steroid-delta-isomerase	gnl\|CDD\|238404	cd00781, ketosteroid_isomerase, ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon. Ketosteroid isomerases are important members of this class of enzymes which are the most proficient of all enzymes known and have served as a paradigm for enzymatic enolizations since its discovery in 1954. This CD includes members of this class that calalyze the isomerization of various beta,gamma-unsaturated isomers at nearly a diffusion-controlled rate. These enzymes are widely distributed in bacteria.	5.24107e-32
CP028731.1\|AYJ05850.1\|3067367_3068780_-\|IS110-family-transposase	gnl\|CDD\|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	8.54636e-20
CP028731.1\|AYJ05841.1\|3055451_3055841_+\|hotdog-fold-thioesterase	gnl\|CDD\|239527	cd03443, PaaI_thioesterase, PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not been determined. Sequence similarity between PaaI, E. coli medium chain acyl-CoA thioesterase II, and human thioesterase III suggests they all belong to the same thioesterase superfamily. The conserved fold present in these thioesterases is referred to as an asymmetric hot dog fold, similar to those of 4-hydroxybenzoyl-CoA thioesterase (4HBT) and the beta-hydroxydecanoyl-ACP dehydratases (FabA/FabZ).	1.4881e-31
CP028731.1\|AYJ05843.1\|3056631_3057606_+\|ABC-transporter-permease	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	9.98974e-98
CP028731.1\|AYJ05844.1\|3057653_3058529_+\|ABC-transporter-permease	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.57881e-85
CP028731.1\|AYJ05833.1\|3047387_3049133_+\|potassium-transporter-TrkA	gnl\|CDD\|367001	pfam02254, TrkA_N, TrkA-N domain. This domain is found in a wide variety of proteins. These protein include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.	5.22298e-19
CP028731.1\|AYJ05849.1\|3065969_3067121_-\|exonuclease-SbcCD-subunit-D	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	4.49131e-63
CP028731.1\|AYJ05836.1\|3051036_3051450_+\|VOC-family-protein	gnl\|CDD\|319898	cd06587, VOC, vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). Type I extradiol dioxygenases catalyze the incorporation of both atoms of molecular oxygen into aromatic substrates, which results in the cleavage of aromatic rings. They are key enzymes in the degradation of aromatic compounds. Type I extradiol dioxygenases include class I and class II enzymes. Class I and II enzymes show sequence similarity; the two-domain class II enzymes evolved from a class I enzyme through gene duplication. Glyoxylase I catalyzes the glutathione-dependent inactivation of toxic methylglyoxal, requiring zinc or nickel ions for activity. The antibiotic resistance proteins in this family use a variety of mechanisms to block the function of antibiotics. Bleomycin resistance protein (BLMA) sequesters bleomycin's activity by directly binding to it. Whereas, three types of fosfomycin resistance proteins employ different mechanisms to render fosfomycin inactive by modifying the fosfomycin molecule. Although the proteins in this superfamily are functionally distinct, their structures are similar. The difference among the three dimensional structures of the three types of proteins in this superfamily is interesting from an evolutionary perspective. Both glyoxalase I and BLMA show domain swapping between subunits. However, there is no domain swapping for type 1 extradiol dioxygenases.	1.10594e-13
CP028731.1\|AYJ05837.1\|3051501_3051897_+\|VOC-family-protein	gnl\|CDD\|319939	cd08351, ChaP_like, ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha), and similar proteins. ChaP is an enzyme involved in the biosynthesis of the potent antitumor agent chartreusin (cha). Cha is an aromatic polyketide glycoside produced by Streptomyces chartreusis. ChaP may play a role as a meta-cleavage dioxygenase in the oxidative rearrangement of the anthracyclic polyketide. ChaP belongs to a conserved domain superfamily that is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases.	1.75777e-66
CP028731.1\|AYJ05847.1\|3062034_3063279_-\|alpha/beta-hydrolase	gnl\|CDD\|366166	pfam00561, Abhydrolase_1, alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.	1.18804e-13
CP028731.1\|AYJ05840.1\|3054287_3055232_-\|sulfate-adenylyltransferase-subunit-CysD	gnl\|CDD\|235375	PRK05253, PRK05253, sulfate adenylyltransferase subunit CysD.	0
CP028731.1\|AYJ05842.1\|3055991_3056483_-\|carbonic-anhydrase	gnl\|CDD\|239474	cd03379, beta_CA_cladeD, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	5.57609e-66
CP028731.1\|AYJ05835.1\|3050091_3050970_-\|LLM-class-flavin-dependent-oxidoreductase	gnl\|CDD\|366009	pfam00296, Bac_luciferase, Luciferase-like monooxygenase.	3.19761e-32
CP028731.1\|AYJ05845.1\|3058525_3060361_+\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|182342	PRK10261, PRK10261, glutathione transporter ATP-binding protein; Provisional.	1.49388e-169
CP028731.1\|AYJ05839.1\|3052437_3054288_-\|adenylyl-sulfate-kinase	gnl\|CDD\|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
CP028731.1\|AYJ05848.1\|3063342_3065973_-\|hypothetical-protein	gnl\|CDD\|227061	COG4717, COG4717, Uncharacterized conserved protein [Function unknown].	1.93303e-09

>CP028731.1|AYJ05841.1|3055451_3055841_+|hotdog-fold-thioesterase
MIAQFLPQSPFVVKLGIVAERLDEDEVRLRLPWDPSNVTIGDMVHGGAIATLADLTVMAAAWCGAQAPPQLRGVTVSMALDFMAPARASDVIGVGRVLRRGRSVVNCEAEIVDPQGTLVAKALATYKVG
>CP028731.1|AYJ05840.1|3054287_3055232_-|sulfate-adenylyltransferase-subunit-CysD
MPKEAMTADLQTAPAAGQYELSHLRSLEAEAIHIIREVAAEFERPVLLFSGGKDSIVMLHLALRAFRPGRLPFPVMHVDTGHNFDEVIATRDELVKQHGLRLVVASVQDDIDAGRVVEPKQGRNPIQTVTLLRAIRENKFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAENIALPSIYYAHRRKVFRRDGMLLAVDRNMQPNPDEPVFEATVRFRTVGDVTCTGCVESQAATVDEVIAETAVSRLTERGATRADDRISEAGMEDRKRQGYF
>CP028731.1|AYJ05839.1|3052437_3054288_-|adenylyl-sulfate-kinase
MAAPTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWAAVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIQHIVLAVNKMDLIGWDREKFESIRDEFHAFAARLDVHDVATIPISALHGDNVVTKSDQTPWYEGPALLSHLEEVYIAGDRNLVDVRFPVQYVIRPHTHEHQDHRSYAGTVASGVMRPGDEVVVLPVGKRTRITAIEGPNGPVQEAFPPMAVSLTLADEIDISRGDLIARTHNQPRIAQDFDATVCWMADNTTLEPGRDYVIKHTTRTTHARVTGLDYRLDVNTLHRDKTATALKLNELGRISLRTQVPLLLDEYTRNPSTGSFILIDPHTNGTVAAGMVLRDASAQAASPNTVRHKSSAIAAARPRGKTVWFTGLSGSGKSSVAMLVEQKLLEKGAQAYVLDGDNLRHGLNADLGFSMADRAENLRRLAHVAALLADCGNVVLVPAISPLAEQRELARKVHADAGFDFIEVFCDTPIEECEKRDPKGLYAKARAGEITQFTGIDSPYQPPAKPDLRLTPDGTVEEQAQRVIDLLESRG
>CP028731.1|AYJ05838.1|3051893_3052379_-|transcriptional-regulator
MRMSAKAEYAVRAMIQLATVPDGTLVKTDDLAQAQGIPPQFLVDILTNLRTDRLVRSHRGREGGYELARPGKDISIADVLRCIDGPLASVRDIGLGDLPYSGPTAALTDVWRALRASMRLVLEETTLADVATGSLPKHVAQLADDYRKQESQRHGTARTGD
>CP028731.1|AYJ05837.1|3051501_3051897_+|VOC-family-protein
MTISFNHTIVASRDKRESAEFLAELFDLPGPKPFGHFMVVELDHGASLDYADAPDGADIPRQHYAFLVSEQEFDTIYGKIRARGLEHWADPGARRPGEINHNDGGRGVYFLDPSGHAMEILTRPYGSGAAN
>CP028731.1|AYJ05836.1|3051036_3051450_+|VOC-family-protein
MGLTNTSIAHVRLTVTDIEQSRRFYESVFGWPVLLEVPDNADASTREQLSFLFGGVIYDLGGTLLGLRPVATDRFDEDRTGLDHIAFRLDSRDELDAAAAHLDELGVAHEPVKDIGPAYILQFRDPDNIALELTAPK
>CP028731.1|AYJ05835.1|3050091_3050970_-|LLM-class-flavin-dependent-oxidoreductase
MTMPVMEPDLDATVLETWARTIDEGPFSSLCWGERIAFDNPDSLTLLGALAAWTERVRLLTTVIVPQLHDPVLLAKGLATGDLLSGGRLSVGIGVGGRQEDYHAVGADPATQTMRGMAERVAVMKRVWAGEKLTESVLPVGPAPVQPGGPPLFVGSIGPKTIRSAAAWADGLAGTTLDLDVAKQRELFDVTRDAWARAGKPAPHLITSFWFAFGSPRTAREQVHRHLRRYMNWIPADYVDAMAPMTGWAGDEDELAEVLRKFAGIGADEVQLIPTSSDVGQLRRAADVAARL
>CP028731.1|AYJ05834.1|3049157_3050030_-|hypothetical-protein
MTQQELPAPLAELTGLLTECTNKGDFVGAARQAGELVTLCRATLGERHPTALELKVSLATLRLRAGECAVAYEEFERLIPDLVEVLGPDHLSTLTARHLLASRQQAALSSLAEWSQLFADEQRVWGADHENTLVAREKIAEKRWEIGDFVGAMAEGEQVLAARRRVLGADHTDTLGTQLMLSIWRGRAGDVPAAVAELEPLIGELREKLGDDHAHVLMARHMFTLWAPERAGVTDAVAAWEALVEEESRVLGDEHPVTLAARQELAGWCARRDGQAGGAGAQGSLDWSAS
>CP028731.1|AYJ05833.1|3047387_3049133_+|potassium-transporter-TrkA
MRDDSPRMSPRRHIIVSGDDVLATTIAEELNRAGATIVKLPSEELAGADLARASAIVCAGRDDAKNLEIALLARKTNPHVRVVARLGNDVLRGAVAADNGPGAILDVADLAAPSVVEACLSSSTHPVRAAGIDFLVSGAEAPRDATLREIYGDLAPVAVIHGNDGATPGEVVPCPGRDHRVRAGDWTAMIGSADELAARGIRTPRPPATRSRQTWLRRVLDAARAMRDDVNPMLFPAILLALTLLLVSTVIVHFSYTKPRLSWLDALYFTAETITTVGYGEFTFAHQSAWLRIFAVGLMFAGVTTTALLVAFLADLLLSRRFLQSAGLRRARHLRNHIIVVGQGSFGSRVVADLTAAGYDVAVIERDENNRFLSTAAELDVPVIFGDATLRQTLESARVDRARAVAVLTQDDMVNIEIGIVLREMLGPRVMPEVNRPDVPIVLRIYDRTLGDAVAKRFGFENVRSTVDLAAPWFIGTAMGLQVLGTFSVGQRSFMVGAMHVAAGSELDGLRMFEMSTQTRVIAITRRDTPVELHPRRDAWLRAGDTVYLVGPYRELLETLRKGQPPQQPANEERPADKATT
>CP028731.1|AYJ05832.1|3046922_3047294_+|steroid-delta-isomerase
MPSAEAITDTVNRYLALVATGTADDIVTLYAADATIEDPIGADIRRGHDAIRAFYAGFQDAKKDTELAELRVSGSEAAFLWHLTLDAGDTRTRISPISTMSFDEDAKITAMRAFWSPTDVQVL
>CP028731.1|AYJ05842.1|3055991_3056483_-|carbonic-anhydrase
MAVTDDYLAHNAGYARSFEGPLPMPPSKHVAVVACMDARLDVYRILGLREGEAHVIRNAGGVITDDVVRSLAISQRLLGTREIILIHHTDCGMLTFTDDDFKRGIQEETGIKPPWAAEAFADLAEDVRQSLRRIEANPFVTKHVSARGFVFDVATGKLDEVKP
>CP028731.1|AYJ05843.1|3056631_3057606_+|ABC-transporter-permease
MTRFLARRLLNYLVLLALASFLTFCLTSVAFKPLDSLLQRSPRPPQAVIDAKAHSLGLDEPIPIRYAHWASHAVRGDFGKTVTGQPVGASLGRRVGVTLRLLVIGSLIGTVAGIAAGAWGAIRQYRLSDRVVTMLALLVLSTPTFVIASLLILAALRVNWALGVQVFDYTGETSPGVTGGAAALLDRLRHLVLPSLTLALAAAAGYSRYQRNAMLDVLGQDFIRTARAKGLTRRRALVKHGLRTALIPLATLFAYGVAGLVTGAVFVEKIFGWHGMGEWLVQGVATQDTNIVAAITLFSGAVVLLAGLLSDVFYAALDPRVRVS
>CP028731.1|AYJ05844.1|3057653_3058529_+|ABC-transporter-permease
MAGFASRRTLVLRRFGRNRLAVTSLTLLVLLFVGCYTLPAVLPYSYQDLDFDALLQPPNARHWLGTNALGQDLLAQILRGMQKSMLIGVCVAVISTGIAATVGSIAGYFGGWRDRVLMWLVDLLLVVPSFILIAIVTPRTKNSANILMLVLLLAGFGWMVSSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVASAILAETGLSFLGFGVQPPDVSLGTLIANGTQSATTFPWVFLFPAGVLVLILVCANLTGDGLRDALDPGSGPARGGRR
>CP028731.1|AYJ05845.1|3058525_3060361_+|ABC-transporter-ATP-binding-protein
MSPLLQVTDLAVTFPAGDAPVTAVRGISYRIEPGEVVAMVGESGSGKSVSAMAVMGLLPEHARVRGSVRLHDTELLGLGDDAMSRLRGRAVGMVFQDPMSALTPVYTVGDQIAEAITIHQPRVGRKAARDRAVELLELVGIAQPQRRARAFPHELSGGERQRVVIAIAIANDPDLLICDEPTTALDVTVQAQILEVLKTARDITGAGVLIITHDLGVVAELADRALVMYAGRVVESAAVASLYRDRRMPYTVGLLGSVPRLDAAQGTRLVPIPGAPPSLAGLDPGCPFAPRCPLAIDECRSQEPELLPVGPDHRAACIRTDQVDGRSAADIYGVRTQPHPGEPANSPVLVRVRELSKTYRLTKGVLRRSAGEVRAVDRISFQLRQGRTLGIVGESGSGKSTTLHEILELVAPQSGSIEVLGTDVAALSPASRRSLRRDIQVVFQDPVASLDPRLPVFELLAEPLRANGFDKDHTNARVAELLETVGLRRADAARYPAEFSGGQKQRIGIARALALQPKILALDEPVSALDVSIQAGIINLLLDLQAQFQLSYLFVSHDLSVVKHLAHDVAVMYAGSIVEQGDSSQVFGNPQHEYTRRLLDAVPQPNPGSRG
>CP028731.1|AYJ05846.1|3060371_3062048_+|ABC-transporter-family-substrate-binding-protein
MGRCGFRPAALVAAVVLAVAGCSPAINLVPETGQNARIGTTSDINPRDPATLQDGGNLRLALTDFPPNFNILHIDGNSADVSAMMKATLPRAFVIGPDGSTTVDTDYFTSVELTGTAPQVVTYTINPKAVWSDGTPITWEDIASQIHALSGADKTFEIAGSSGAERVASVTRGVDDRQAVVTFAKPYAEWRGMFAGNGMLLPKSMTATPEAFNKGQLEGPGPSAGPFIVSSLDRTTQRIVLSRNPKWWGTRPRLDSITYLVLDDAARLPALQNNTIDATGVGTLDQLTIAEHTAGISIRRAPAPAWSHFTFNGAPGSILADRALRVAVSKGIDRQTIAKVVQYGLTSNPVALGNHIYVAGQQGYQDNSTTVPYDPAAAGRELDALGWKLHGRFREKDGRQLVIRDLFYDAQGSRQFAQIAQHSLAQIGVRLELVARAGSGFFTNYINVGAFDMAQFGWLGDAFPLSALTQIYKSDGESNFGKIGSPQIDAAIERTLQELDPDKARALANDLDKLIWAEGFSLPLTQSPGDVAVRSTLANFGAAGLGDLNYTAIGFTRS
>CP028731.1|AYJ05847.1|3062034_3063279_-|alpha/beta-hydrolase
MTMNAKRRRMQQRLAKLPGVRAVRRPISPDTADEFDLYYVRAGRKSRHPVVIIPGGPGVASVQMYKGLRRRAAAAGLDVIMIEHRGVGMSRHDDAGADLPPEAMTVNQVVDDVAAVLDDARVDSAVVYGASYGTYIASGVGVRHPARVHGMVLDSPLLSRHDIVIVRRAIRRLLLRGDSPETASLAPKMRKLVDAGLMTATATQVVATIYGYGGARLLERQLDLLLDGRKLLWWTLSRFTTLRNLPFRYEEDLVSRIALRELDYAAEPDGLPLDPAVAEREVRTQTATFEDEPYDLPAEMPSFDWPTAVVSGGRDLITPPAVAERVASLLPHAVLLSLPDMAHSALDFHEAVALASADAVLRGDLAGLAARACTLNALPPRPEVRLLWALIAAAAMIEGALPIPAPLRRRLSCG
>CP028731.1|AYJ05848.1|3063342_3065973_-|hypothetical-protein
MKLHRLTLTNYRGIAHREIEFPDHGVVVVCGANEIGKSSMIEALDLLLEAKDRSTKKEVKQVKPTHSDVGAEVSAEISCGPYRFVYRKRFHKKCETELTVITPYREQLTGDEAHERVRAMLAETVDSDLWHAQRVLQAASTAAVDLSGCDALSRALDVAAGDSGGLCGTEPLLIERIDAEYARYFTPTGRPTGEWAAAIARLADAEAAVAECAAAVAEVDERVSRHAALTEQVADLSQRRIAAGPRVTAARQAADRIAELTAQRREAQLVAEAAAATKAAAAQAHSGRLQLLADIDSRAAAVTQTQAQVQQAAADHAAARADAQACDTALQHATEALAELERRVQEAQRTVERLAGREEADRLAARLDKIDAIQRDRERISAELSTIAVTEELLRRIEDAAAAVDRIGDQLASTSAAVEFTAVADIHLVIGDRQVSLPAGQSWSITAVGPTAVEVPGVLTARVIPGATTLDVQAKHAAAQQELAAALMAGAVADLAAARSADQRRRELQGTRDQLGATLAGLCGDEPHDELRSRLARLRAEHPEQPAEPTGGAADLAAARTELETLAQARACASAECDTHRQAATAAAARLAETATAATVLQNRLDTLRAELDAATGRLAAERASVGDEELAASADAALRAEQAAERRVAELADALAAASPDSVAAELADATQESESLRERYEEAAGALREVTIELSVFGSEGRQGKLDAAETEREHAASEHSQVGRRARAAQLLRSVMTRHRDTTRQRYVEPYRAELQRLGRPVFGPTFEVDIDSDLCIRSRTLNGITVPYESLSGGAKEQLGILARLAGAALVAKEDAVPVVVDDALGFTDPDRLAKMGQLFDSVGSHGQVIVLTCSPDRYDGVKGAHRIDLSA
>CP028731.1|AYJ05849.1|3065969_3067121_-|exonuclease-SbcCD-subunit-D
MRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLGALAAEVGAEFVVVSGDVFEHNQLPPKVVGQSLEAMRAIGIPVYLLPGNHDPLDASSVYTGALFTAERPHNVTVLDRAGVHQVRPGLQLVAAPWRSKVPTTDLVGEVLDGLPETDDTRILVGHGGVDVLDPDRDKPSLIRLAKLEDALTRGAVHYVALGDKHSLTQVGSSGRVWYSGSPEVTNFDDVEADPGHVLIVDIDEADPRRPVSVTARRIGCWRFVTLHRQVDSSRDIADLDMNLDLMTNKDRTVVRLALTGSLTVTDRAALDACLDKYARLFAHLRTWDSHTELAVIPADGEFSDLGIGGFAAAAVEELVATARQQDSDTAADAQGALALLLRLADRGAA
>CP028731.1|AYJ05850.1|3067367_3068780_-|IS110-family-transposase
MCVELILGIDVACRAAHQASLARPDGTYVWTGRKFFTRPADLEKLWKVIGLSEQDTVRVVMEPTRNAWVPLASWFRHHGARISMVPTTQSADLRAYYSKHTKNDHLDSKLLARLPLLHPEGLRDHSGDGPGEPLRRLVKIRSSIVKRRTAVFQRLDAQLELLGPAWYDALGSNYGKAALALLARYADPHSLIRLGHARLTRFLIRHSRGAWREPHATLLLTAAQESLQLWGSGANARIDFAELAADIATEAEQAQMLTEQIDDLDERAANLYAEADPRGIIASAPGVGPVTCAVIAGRIGDPHRFHSLAAIRAYSGLVPKVNQSGQAEQRHGLTKAGDPLLREALFAAADQARKSDPQLAAKYKRLMSTERHHDSAICHIATILLTRIATCWRAGAHYVLRDTDGRPITFEEGRRIVRAHHTVDKKTRINAASKRYSQRQKGRTGREQQESLRAPIHRPVHPSIKPTEVA
>CP028731.1|AYJ05851.1|3069020_3070439_+|hypothetical-protein
MSSGSIIDRDAISAAFDALDAALDGVAALGFDGLTPRECLALLGRCEKARRRLPVAEHQLINLVARQASPAELGGRLSHAIAEATLISRAEAARRVHTAADLSPRVGLTGEPLPPLLAATAARQREGSLGPEQVAVIRKFCHQLPGWIDQATRERAETDLAREGTRYRPEHLAALAGTLADCLNPDGLYRDEDRARRRSLTLGNQHADGMSELRGLLTPELRATLEAVLAKLAAPGMCNPLDENPCVDGTPTEQAIDDDARSAAQRNHDGLLAGLRALLASGNLGQHNGLPASIIVTTTLADLQAAAGRGLTGGGTLLPMSDVIRLSRHAHHYLAIFDHGKALALYHTKRLASPAQRIVLYAKDRGCTAPGCTVPGYYAEVHHCTDYATCHTTNINDLTFACGPHHRLLQPGAWTTHKNTRGETQWLPPPHLDRNQPRTNTFHHPEKLLQGEDDEDEADGEQEADQGDDHAA

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Crispr_ID: CP028731_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028731_4

4729890-4729966

Orphan

Consensus_repeat	Method
GCGCGCCCATGGCGCTCGTCGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028731_4

>merge|CP028731|4|4729890-4729966|CRISPRCasFinder
GCGCGCCCATGGCGCTCGTCGCGCCCCTCAGGGGCCGACGGTTCGGCTTGCTCCTCGCGCCCATGGCGCTCGTCGCG

>CP028731|4|4|4729890-4729966|CRISPRCasFinder
GCGCGCCCATGGCGCTCGTCGCG	CCCCTCAGGGGCCGACGGTTCGGCTTGCTCC
TCGCGCCCATGGCGCTCGTCGCG

Protein	Signature genes	Signature genes Name	Protein_function
CP028731.1\|AYJ07254.1\|4742120_4742369_+\|hypothetical-protein	unknown	unknown	unknown
CP028731.1\|AYJ07807.1\|4740914_4742027_+\|alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176241
CP028731.1\|AYJ07247.1\|4731580_4733146_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|273384
CP028731.1\|AYJ07242.1\|4725555_4726527_-\|RDD-family-protein	unknown	unknown	gnl\|CDD\|377640
CP028731.1\|AYJ07238.1\|4722450_4723560_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378342
CP028731.1\|AYJ07251.1\|4736360_4737176_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223838
CP028731.1\|AYJ07252.1\|4739930_4740371_-\|cyclase	unknown	unknown	gnl\|CDD\|176861
CP028731.1\|AYJ07237.1\|4720947_4722414_+\|YhgE/Pip-domain-containing-protein	unknown	unknown	gnl\|CDD\|224428
CP028731.1\|AYJ07241.1\|4725004_4725559_-\|mammalian-cell-entry-protein	unknown	unknown	unknown
CP028731.1\|AYJ07243.1\|4726523_4727225_-\|Mce-protein	unknown	unknown	unknown
CP028731.1\|AYJ07235.1\|4719247_4720138_+\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224332
CP028731.1\|AYJ07239.1\|4723552_4724218_-\|DUF1275-domain-containing-protein	unknown	unknown	gnl\|CDD\|377734
CP028731.1\|AYJ07240.1\|4724282_4725038_-\|mammalian-cell-entry-protein	unknown	unknown	gnl\|CDD\|237030
CP028731.1\|AYJ07244.1\|4727194_4728745_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|224380
CP028731.1\|AYJ07253.1\|4740414_4740900_-\|acyl-CoA-thioesterase	unknown	unknown	gnl\|CDD\|223894
CP028731.1\|AYJ07250.1\|4735489_4736359_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223838
CP028731.1\|AYJ07248.1\|4733142_4734183_-\|virulence-factor-Mce-family-protein	unknown	unknown	gnl\|CDD\|273384
CP028731.1\|AYJ07246.1\|4729970_4731584_-\|virulence-factor-Mce-family-protein	unknown	unknown	gnl\|CDD\|273384
CP028731.1\|AYJ07236.1\|4720163_4720889_+\|pirin-family-protein	unknown	unknown	gnl\|CDD\|380375
CP028731.1\|AYJ07249.1\|4734179_4735484_-\|MCE-family-protein	unknown	unknown	gnl\|CDD\|378749

Protein	Function_ID	Function_description	E-value
CP028731.1\|AYJ07807.1\|4740914_4742027_+\|alcohol-dehydrogenase	gnl\|CDD\|176241	cd08281, liver_ADH_like1, Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase). NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. This group contains members identified as zinc dependent alcohol dehydrogenases (ADH), and class III ADG (aka formaldehyde dehydrogenase, FDH). Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. Class III ADH are also know as glutathione-dependent formaldehyde dehydrogenase (FDH), which convert aldehydes to the corresponding carboxylic acid and alcohol. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which have a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	1.29441e-149
CP028731.1\|AYJ07247.1\|4731580_4733146_-\|MCE-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	7.87823e-82
CP028731.1\|AYJ07242.1\|4725555_4726527_-\|RDD-family-protein	gnl\|CDD\|377640	pfam06271, RDD, RDD family. This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family. This region contains two predicted transmembrane regions. The arginine occurs at the N-terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	1.68132e-13
CP028731.1\|AYJ07238.1\|4722450_4723560_+\|hypothetical-protein	gnl\|CDD\|378342	pfam09992, NAGPA, Phosphodiester glycosidase. This is a family conserved from bacteria to humans. The structure of a member from Bacteroides has been crystallized and modelled onto the luminal region of the human member of the family, the transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. There is some conservation of potentially functional residues, implying that in the bacterial members this family acts in some way as a phosphodiester glycosidase. The human protein is also present, so the eukaryotic members are likely to be catalyzing the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides.	0.000457806
CP028731.1\|AYJ07251.1\|4736360_4737176_-\|ABC-transporter-permease	gnl\|CDD\|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	1.098e-87
CP028731.1\|AYJ07252.1\|4739930_4740371_-\|cyclase	gnl\|CDD\|176861	cd07819, SRPBCC_2, Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins. Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.	4.15327e-44
CP028731.1\|AYJ07237.1\|4720947_4722414_+\|YhgE/Pip-domain-containing-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	6.8684e-50
CP028731.1\|AYJ07235.1\|4719247_4720138_+\|MarR-family-transcriptional-regulator	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	8.76371e-17
CP028731.1\|AYJ07239.1\|4723552_4724218_-\|DUF1275-domain-containing-protein	gnl\|CDD\|377734	pfam06912, DUF1275, Protein of unknown function (DUF1275). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although most members have 6 TM regions, and may be putative permeases.	1.87337e-27
CP028731.1\|AYJ07240.1\|4724282_4725038_-\|mammalian-cell-entry-protein	gnl\|CDD\|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00629665
CP028731.1\|AYJ07244.1\|4727194_4728745_-\|MCE-family-protein	gnl\|CDD\|224380	COG1463, Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism].	2.68138e-77
CP028731.1\|AYJ07253.1\|4740414_4740900_-\|acyl-CoA-thioesterase	gnl\|CDD\|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	2.43707e-35
CP028731.1\|AYJ07250.1\|4735489_4736359_-\|ABC-transporter-permease	gnl\|CDD\|223838	COG0767, Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism].	9.52641e-81
CP028731.1\|AYJ07248.1\|4733142_4734183_-\|virulence-factor-Mce-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	4.72889e-88
CP028731.1\|AYJ07246.1\|4729970_4731584_-\|virulence-factor-Mce-family-protein	gnl\|CDD\|273384	TIGR00996, Mtu_fam_mce, virulence factor Mce family protein. Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis].	8.2028e-90
CP028731.1\|AYJ07236.1\|4720163_4720889_+\|pirin-family-protein	gnl\|CDD\|380375	cd02910, cupin_Yhhw_N, Escherichia coli YhhW and YhaK and related proteins, pirin-like bicupin, N-terminal cupin domain. This family includes the N-terminal cupin domains of YhhW and YhaK, Escherichia coli pirin-like proteins with unknown function. YhhW is structurally similar not only to human pirin but also to quercitin 2,3-dioxygenase (quercitinase). Although the function of YhhW is not completely understood, YhhW and its human ortholog have quercitinase activity and are likely to play an important role in transcription and apoptosis. This N-terminal cupin domain of YhhW has a metal coordination site and is thought to have catalytic activity while the C-terminal cupin-like domain has diverged considerably and has closer alignment with C-terminal pirin. YhaK is found in low abundance in the cytosol of E. coli and is strongly up-regulated by nitroso-glutathione (GSNO). There are major structural differences at the N-terminus of YhaK compared with YhhW; YhaK lacks the canonical cupin metal-binding residues of pirins and may be involved in chloride binding and/or sensing of oxidative stress in enterobacteria. YhaK showed no quercetinase and peroxidase activity; however, reduced YhaK was very sensitive to reactive oxygen species (ROS). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	2.4526e-72
CP028731.1\|AYJ07249.1\|4734179_4735484_-\|MCE-family-protein	gnl\|CDD\|378749	pfam11887, Mce4_CUP1, Cholesterol uptake porter CUP1 of Mce4, putative. Mce4_CUP1 is a family of putative Mce4 transporters of cholesterol. The domain is found associated with pfam02470. The full TCDB classification for this family in conjunction with PF02470 is TC:3.A.1.27.4.	2.84668e-104

>CP028731.1|AYJ07244.1|4727194_4728745_-|MCE-family-protein
MLTPFVRRQLVAFGILTVISLLVLGIYYLQIPSLVGIGRYTLKAELPASGGLYPTANVTYRGITIGKVTDVEPTEHGAEATMSIDSHYKIPIDAVANVHSVSAVGEQYLDLVSSGNPGKYLSSGQTITKGTVPAEIGPALDTANRGLAVLPKEKIGQLLDETAQSVGGLGPNLQRLVDATQAIVGDFKNQITDVNDIIEHSGPVIDSQVKSGDAIERWARNLNRLGAQSAQEDSHLKSLLRQAGPTADQVNDVFNDVRESLPQTLANLEVVIDLLKRYHTGVEQVLVVLPQGASIAQTVAAPFPNMAALDLALSINQPPPCLTGFIPASEWRSPADTSLQPLPTGTYCKIPMDTPANSVRGSRNIPCTDIPGKRAATPRECRDPKPYVPAGTNPWYGDPNQILTCPAPAARCDQPVKPGMVIPAPSVDNGLNPAPSDRVAGTPPPVSDPLSRPGSGTVQCNGQQPNPCVYKPSGPPTAVYSPQSGELVGPDGVKYSVENSTRTGDDGWKEMLAPAG
>CP028731.1|AYJ07243.1|4726523_4727225_-|Mce-protein
MEGDAGASRLNPIDTDDDSLSPQDKDEDSTAPASTDEQTGSQGAPGVAGESAPDDADDAVPVAAVPRGPSRLGRGWLAAIAAVLVLCAAGIGAGGYLALRYHHESQVIARNNAAALKAAVDCVEATQAPDTNAMTASEQKIIDCGTDAYRSQALLYTSMLVQAYQSANIHVQVSDVRAAVERNNPDGSIDILVALRVKVASDQSQNESGYRLRVKMALAEGQYKISKLDQVTK
>CP028731.1|AYJ07242.1|4725555_4726527_-|RDD-family-protein
MTVLVEQAATMGTPEPVREALAPWHSRVGAFAIDVAPGAAVIATMALVSFTVPARGVWWWVGVCVLGVVTLLALVNRLLLPVITGWSLGRALAGIAVTRRTGAAPGPWRLLLRDLAHLLDTASIVGWLWPLWDSRRRTFADMLAGTEVRRLAPEQVPPHITRWAAAAVLGAAAVCLGGAAMSYGVVYSADRASDQTRAQIATQGPKIVAQMLTYDPKSLHDDFARAQSLATDKYRRQLQTQQDVVQKGNPVINEYWVTNSSIESASRDRATMLLFMQGRRGAAPEVRYISATVRVSFAKVGENTWRVDDLTVLTKPKPPGGAK
>CP028731.1|AYJ07241.1|4725004_4725559_-|mammalian-cell-entry-protein
MSPRRKFAPGERPLLVARPVRPPRGWLLPLAGTAAALLMVTAVTLCALMLVSHESRERAASKDREVLSYVSGFMTQFTSIDPFHANDYVNRILAQATGDFAKQYEKNANEILLQVARAEPATGTVLDAGLERWNDDGSANVMVATAITTKSPDEKQVLENTNRWAATATQEGNQWKISSLQQVI
>CP028731.1|AYJ07240.1|4724282_4725038_-|mammalian-cell-entry-protein
MEDQQPAAGDLTAEENPAADQNEATVAAAGDDRENGDAATESEAAKTSDAAPADGAEDSHSAETVETAGAAPAAGRRTKRLAGKAWAVAAMVAALLFVGSAGFAGAMVQPYLADRAVAATKLKVARTAANAITTLWTYTPENMDTLADRASAYLSGDFEAQYRKFVDAIVAPNKQAKITNHTDVTGAAVESLDDTNAVVIVYTNTTSTSPLTKNVPSLKYLSYRLFMKRAKSRWLVTRMTTITSLDLTPKV
>CP028731.1|AYJ07239.1|4723552_4724218_-|DUF1275-domain-containing-protein
MAALLLLTFATGLADAISILVLGHVFVANMTGNVIFLGFWLAPRTSIDLTAVVVALPTFACTTILSGRLARHFGERVRAWISTVLATEIVLLVGLSVLAGSGILSYQQDSKLLMIGILAVTFGLQHSSARQFGIQEFSTTVLTSTIVSLGLDSRLAGGSGERQRLRIGVVATMCAGAFLGATMSRYVVAPVFVVAAAVIAASLLIFRFGPPAAKPAAAEAN
>CP028731.1|AYJ07238.1|4722450_4723560_+|hypothetical-protein
MHFMAERAIVLTRRASFRRLAACCTALSACLTLAVTSGQPLARAADGRDLLANAISSTRGSYLVYNFGPGHPAPMLNAGGSWYEMNNGGHLMIIKNAAGRLSPHLLVDTHQGDQARCENNPGARTAEGLWQASELYAPLQAWQRMGQPTIAINANFFDVRPQKGGSWRQTGCSSPLGAFVDNTNGRGRANQAVTGTVAYPGKQGLSGGGESWSALTTMILPSGGAPYVVWPKTKSDYDAATPVVADLLNKNEKFVAVSGIGLLAPGNTGQLHDGGPSAARTAIGYARQKDEMYIFEGGSYTPDNMQDLFRGLGSDNAVLLDGGGSSAIVLRRDTGGMWAGAGSPRGSCDTRQVLCDSHERALPSWLAFN
>CP028731.1|AYJ07237.1|4720947_4722414_+|YhgE/Pip-domain-containing-protein
MARSHPQHAAPNPNRNIKAVRTVRFWAAPLVITLALMSALCALYLGGILNPTTNLRHFPIAVVNEDAGPGGAQIVDRLATGLDRNKFDIRVLSRDEAKHQLDTGRVYGSLLIPPSFSSKLRDFATSAVSPARPDKPSITVSTNPRAGTLGASIAGQTLNSAMGTANGIAAQRVMAEVTAQTGGAPLPGATQAGLSSPIEIQSVVYNPLPNGTGNGLSAFYYALLLLLAGFTGSIVVSTLVDALLGYVPAEFGPVYRFAEQVRISRFQTLLLKWAMMVLLGLLTSAVYLAIANGLGMPIDLSWELWAYGVFAIAAVGITSSSLLSVLGTAGMLVSMLVFVIFGLPSAGATVPLEATPPLFRWLAEFEPMHQVFLGTRSLLYFGGRGDAGLSQALTMTSAGLVIGLLLGGIVTHLYDRKGFHRIPGAVEFAIAQDHQAQHQARRGKSTQPPDSPVEPETPAEPESPTNLKAQARKRNSDVPGTSPTRYLY
>CP028731.1|AYJ07236.1|4720163_4720889_+|pirin-family-protein
MSAGFEIRRAATRAVTTTPWLTSRHSFSFGDHYDPDNTHFGLLLVNNDDIVSPGTGFDTHPHRDMEIVTWVLAGALAHQDSTGNRGVVYPGLAQRMSAGRGILHSERNDSPSLPVHFVQMWVIPDEAGIDPSYQQHEIDDTALGGGLVTIASGIRGHDAAISLHNRNAALHGARLPAAAAVDLPAAPCLHVFLARGRADIEDVGELHPGDAVRFTDTDGRRVTGLEPSELLIWEMHARLGG
>CP028731.1|AYJ07235.1|4719247_4720138_+|MarR-family-transcriptional-regulator
MAKSIGETPRRSGVKSPPTARVMDVLAAVADSPGGLTSAELAKGCAISSSTCALVLAELERRAWVTRRDDRRYVLGSGLFGLVHGLREQFPLLDRGRDALRLLHERLGAGCSMSKIGARHLTTVDSVGHGTDGEHAVGQRFPIDPPFGLVAMAWRDDDAVQAWLRRVTPRLTRTEIAQHQRVLADIRARGYGAWRFDDTHRSLHNRLAEALASLEPTAQVARRLTTLMTMVTLRSVTDVLETELPTTEFVVLPIFGHDGQPEYQIEIHLGHSAGLTLPELDDALEQARRLLTAPVR
>CP028731.1|AYJ07246.1|4729970_4731584_-|virulence-factor-Mce-family-protein
MSTIFDIRNIRLPKLSRTSVILGALVIVLALVVGYVGWRLYEKLTNNTVVAYFPAANALYPGDKVQIMGLRVGAIDKIEPSGDKMKVTFHYQNKYRVPANASAVILNPTLVASRAIQLEPPYKGGPVLADNAVIPEERTQVPVEWDQLRNSITNIISKLGPTAEQPKGPFGEVIESFADGLAGKGKQFNTTLTNLSRALTALNEGRGDFFAVVRSLALFVNALHQDDQQFVALNQNLADFTTRLAHSDGDLANAIEQFDSLLTTVRPWLDKNRGVLTYDVKNLETATNALLQPDPLNGLETALHVLPTAAANINQIYHPSHGSVVAIPSITNFANPMQFICSAIQAGSRLGYQESAELCAQYLAPILDAIKFNYPPFGLNLFSTAETLPKEVAYSEPRLQPPNGYKDTTVPGIWVPDTPTSHRNTQPGWIVAPGMQGQQVGPITAGLMTPDSLEELMGGPNIAPVQSNLQTPPGPPNAYDENPILPPMGLNAPVPIPPPPPGPGVAPGPVAPTPAPVSAPAPNAGGPAAPADFGGGQ
>CP028731.1|AYJ07247.1|4731580_4733146_-|MCE-family-protein
MRTLEPPNRVRIGLMGIVVTVLVIGVGQSFTSVPMLFAKPSYYGQFTDSGGINTGDKVRIAGMDVGKVEGLKIDGDHIVVKFSIGTNTIGTESRLAIKTDTILGKKILDVEARGSQQLRPGSTLPLGQSTTPYQIYDAFFDVTKAAQGWDIETVKQSLHVLSQTIDQTYPHLSPALDGVAKFSDTIGKRDEQVKHLLAQANQVASVLGDRSDQIDRLLVNTKTLLAAFNERGQAINALLGNIAAFSEQVKGLINDNPNLNHVLEQLRTVSDILVQRKDDLANGLTEVGKFLPSLNEAIASGPFFKVVLHNLALYQISQPWVDAAFKKRGIDPEDFWRSAGLPAYRFPDPNGTRFPNGAPPPAPPVLEGTPDHPGPAVPPGSPCSYTPAADGLPRPDNPLPCAGAVTGPFGGPGFPAPVDVMTSPPNPAGLPPTPGIPIAGRPGDAPPDVPGTRVPLPTQAPPGARTENLAPAGPVPPPSTFAPGLPPGPPAPPGPGNQLPAPFINPGGTGGSGAAGGGSQN
>CP028731.1|AYJ07248.1|4733142_4734183_-|virulence-factor-Mce-family-protein
MKITGTLVRLSIFSVVLLIFTVMIIVVFGQMRFDRTNGYSAEFSNISGLRAGQFVRASGVEVGKVSSVQLVDGGKRARVEFNVDRSVPLYQSTTAQIRYLDLIGNRYLELKRGQGEGADKVLPPGGFIPLSRTQPALDLDALIGGFKPLFRALDPQKVNTIATALVTVFQGQGGTINDILDQTAQLTSQLGERDQAIGEVIKNLNTVLDTTVRHRQQFDQTINNLEVLITGLKDHGDQLAGGTAHISNAAGTVADLLAEDRSLLHKTLNYLDAVQQPLIDQQDQLQDYLKKVPTALNMIGRAIGSYGDFVNFYACDITLKINGLQAGGPVRTVRLFQQPTGRCTPQ
>CP028731.1|AYJ07249.1|4734179_4735484_-|MCE-family-protein
MARPVQTNAPRTPPYKLAGLAILVVGALALALIYGQFRGNFTPKTSLTMLASRAGLVMDPGSKVTYNGVEIGRVGTISETVRDGKPAAKFTLEVYPRYLKLIPSNVNADIKATTVFGGKYVSLTTPAHPSPQKITPHTIIDARSVTTEINTLFQTITSIAEKVDPVKLNLTLSAAAQSLSGLGEKFGQSVVNANALLDDVNPRMPQARKDIQGLAALGDTYADASPDLFDFLNNAVITSRTINAQQKDLDQALLSAAGFGNTGAELFTKGGPYLARGAQDLIPTAQLLDTYSPEIYCLMRNEHDALPATGAAEGGFNGYSLNMNTEALSGLGLIANPVSAVPVIASMVGGIVGVVGGAPNPYIYPENLPRVNARGGPGGAPGCWQPITHDLWPAPELVIDSGNSLAPYNHLDTGSPYAIEYVWGRQVGDNTINP
>CP028731.1|AYJ07250.1|4735489_4736359_-|ABC-transporter-permease
MSTAAVFRSRFPRAAENLNRYGLAAARGLDDVGQMAWFGGVALAHIPHALSHYRKETLRLIAQIGMGTGAMAVIGGTVAIVGFVTLSGSSLVAIQGFASLGNIGVEAFTGFFAALINVRIAAPVVTGIAMAATVGAGATAELGAMRISEEIDALEVMGIKSISFLATTRIMAGLVVIIPLYALAMIMSFLSPQITTTVLYGQSNGTYEHYFRTFLRPDDVFWSFLEAIIITAVVMITHCFYGYNAGGGPVGVGEAVGRSMRFSLVSVQVVVLAAALALYGVNPNFALTV
>CP028731.1|AYJ07251.1|4736360_4737176_-|ABC-transporter-permease
MTSTSTSRRGPYLVGYLRDQLETPLTLVGGFFRMCVLTGKALFRWPFQWREFVLQCWFIMRVAFLPTIMVSIPLTVLLIFTLNVLLAQFGAADLSGAGAAIGAVTQLGPLTTVLVVAGAGSTAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVIAATLVATLLNGLVITVGLVGGYLFGVYLQNVSGGAYLATLTTITGLPEVVIATVKAAVFGLIAGLVGCFRGLTVRGGSKGLGTAVNETVVLCVVALYAVNVVLTTIGVRFGTGH
>CP028731.1|AYJ07252.1|4739930_4740371_-|cyclase
MPVLSKTVEVNTDAAAIMAIVADFERYPEWSDGVTGCWVLARYDDGRPSQLRLDAAYQGFEGVYIQAVYYPGPNQIQTVMQQGELFKKQEQLFSVVEMGASSLLTVDIDVEPSMPVPAPMVKSMLNNVLDHLADNLKQRAEQLAAN
>CP028731.1|AYJ07253.1|4740414_4740900_-|acyl-CoA-thioesterase
MASAPVVPPAPEGLTSNDFPVLWPVGTRWADNDMFGHLNNAVYYQLFDTAINGWINTSTGLDPLTTPALGIVAESGCRYLSELHFPEGLQVGLAVTRLGRSSVTYRLGVFRSAAPGSAEPITALGHWVHVYVDRDTRKPVPIPDPIRTLLAGAAVGDAAPK
>CP028731.1|AYJ07807.1|4740914_4742027_+|alcohol-dehydrogenase
MSGIRGAVLQRIGAPRPYARSRPISITDVELAPPGRDEVLVRIEAAGICHSDLSVVDGNRVRPVPMLLGHEAAGIVERVGPGVADLAVGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLSRAGRPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAVLNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAARRLGAHQAYTPQQAVEARVKAAVVIEAVGHPAALQTAIDLTAPGGRTITVGLPPPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVELWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRFDA
>CP028731.1|AYJ07254.1|4742120_4742369_+|hypothetical-protein
MAQSALKHGYSIEEISHAYDNYVFEGTIDDGADPPKILTIGPDSAANLLELVGGRRPNGDHLIWHAMRCRRQYLILVPDCGM

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP028731_4	4.1\|4729913\|31\|CP028731\|CRISPRCasFinder	4729913-4729943	31	NZ_CP032685	Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence	1428865-1428895	8	0.742
CP028731_4	4.1\|4729913\|31\|CP028731\|CRISPRCasFinder	4729913-4729943	31	NZ_CP032690	Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence	1428843-1428873	8	0.742
CP028731_3	3.1\|3055869\|34\|CP028731\|CRISPRCasFinder	3055869-3055902	34	NZ_CP014802	Salipiger profundus strain JLT2016 plasmid pTPRO6, complete sequence	180241-180274	9	0.735

1. spacer 4.1|4729913|31|CP028731|CRISPRCasFinder matches to NZ_CP032685 (Rhizobium sp. CCGE531 plasmid pRCCGE531d, complete sequence) position: , mismatch: 8, identity: 0.742

cccctcaggggccgacggttcggcttgctcc	CRISPR spacer
atcaggcggggccgacggttccgcctgctcc	Protospacer
 .*    ************** **.******

2. spacer 4.1|4729913|31|CP028731|CRISPRCasFinder matches to NZ_CP032690 (Rhizobium sp. CCGE532 plasmid pRCCGE532d, complete sequence) position: , mismatch: 8, identity: 0.742

cccctcaggggccgacggttcggcttgctcc	CRISPR spacer
atcaggcggggccgacggttccgcctgctcc	Protospacer
 .*    ************** **.******

3. spacer 3.1|3055869|34|CP028731|CRISPRCasFinder matches to NZ_CP014802 (Salipiger profundus strain JLT2016 plasmid pTPRO6, complete sequence) position: , mismatch: 9, identity: 0.735

gcgcccgagttgtcggccggcgcccgagttgtgt---	CRISPR spacer
gcgcccgcgttgtcgcccggcgcc---accatgtcga	Protospacer
******* ******* ********   ....***

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

458870 : 465442

Bacillus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYJ03788.1\|458870_459803_+	short chain dehydrogenase	W8CYX9	Bacillus_phage	4.6e-05	35.9
AYJ03789.1\|459737_460781_-	DNA polymerase IV	F1C5A5	Cronobacter_phage	1.8e-18	27.6
AYJ03790.1\|460780_461395_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
AYJ03791.1\|461488_462043_+	NAD(P)H-dependent oxidoreductase	A0A2P0ZL77	Lactobacillus_phage	5.4e-06	33.6
AYJ03792.1\|462230_462497_+	hypothetical protein	NA	NA	NA	NA
AYJ03793.1\|462572_462812_+	NrdH-redoxin	V5UN81	Mycobacterium_phage	2.0e-21	64.5
AYJ03794.1\|462854_463307_+	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	A0A142F1R4	Bacillus_phage	1.7e-13	37.7
AYJ03795.1\|463276_465442_+	class 1b ribonucleoside-diphosphate reductase subunit alpha	V9VI16	Lactococcus_phage	7.4e-208	51.6

DBSCAN-SWA_2

677324 : 705243

Corynebacterium_phage(40.0%)

integrase,tRNA,transposase

attL 678839:678898|attR 705406:706884

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYJ03979.1\|677324_678587_+\|tRNA	histidine--tRNA ligase	NA	NA	NA	NA
AYJ03980.1\|678607_678832_-	deoxyribodipyrimidine photolyase	NA	NA	NA	NA
678839:678898	attL	NA	NA	NA	NA
AYJ03981.1\|679060_680266_+\|transposase	IS110 family transposase	NA	NA	NA	NA
AYJ03982.1\|681116_683018_+	hypothetical protein	NA	NA	NA	NA
AYJ03983.1\|683113_683587_+	hypothetical protein	NA	NA	NA	NA
AYJ07493.1\|684121_685342_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	1.8e-62	40.3
AYJ03984.1\|685263_686370_+\|integrase	integrase	A0A220NQQ9	Corynebacterium_phage	1.9e-10	32.2
AYJ07494.1\|686420_688598_+\|transposase	transposase	NA	NA	NA	NA
AYJ03985.1\|688587_689019_+\|transposase	transposase	NA	NA	NA	NA
AYJ03986.1\|691049_692867_-	hypothetical protein	NA	NA	NA	NA
AYJ03987.1\|692832_693774_+	UDP-glucose 4-epimerase	A0A2K9L0I7	Tupanvirus	4.1e-38	35.1
AYJ03988.1\|693770_694112_-	DUF2304 domain-containing protein	NA	NA	NA	NA
AYJ03989.1\|694108_694810_-	glycosyltransferase family 2 protein	NA	NA	NA	NA
AYJ03990.1\|694845_696096_-	hypothetical protein	NA	NA	NA	NA
AYJ03991.1\|696223_697312_+	DUF475 domain-containing protein	A0A172Q0Y5	Acinetobacter_phage	2.4e-53	41.3
AYJ03992.1\|697292_697781_-	inorganic diphosphatase	A0A2H4J8U1	uncultured_Caudovirales_phage	7.3e-31	45.1
AYJ03993.1\|697902_699288_+	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	NA	NA	NA	NA
AYJ03994.1\|699964_700747_+	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
AYJ03995.1\|700746_701325_+	TetR family transcriptional regulator	NA	NA	NA	NA
AYJ03996.1\|701341_701740_+	extradiol dioxygenase	NA	NA	NA	NA
AYJ03997.1\|702013_702325_+	PE family protein	NA	NA	NA	NA
AYJ03998.1\|702349_703540_+	PPE family protein	NA	NA	NA	NA
AYJ03999.1\|703640_703955_+	type VII secretion protein EsxD	NA	NA	NA	NA
AYJ04000.1\|704037_705243_-\|transposase	IS110 family transposase	NA	NA	NA	NA
705406:706884	attR	NA	NA	NA	NA

DBSCAN-SWA_3

962848 : 997753

uncultured_Mediterranean_phage(28.57%)

protease,integrase,holin,transposase

attL 963241:963256|attR 998240:998255

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYJ07517.1\|962848_964042_+\|protease	serine protease	A0A1B1IRH0	uncultured_Mediterranean_phage	2.6e-05	25.0
963241:963256	attL	NA	NA	NA	NA
AYJ04221.1\|964034_965000_-	alpha/beta hydrolase	NA	NA	NA	NA
AYJ04222.1\|965000_965540_-\|holin	phage holin family protein	NA	NA	NA	NA
AYJ04223.1\|965760_966432_+	peptidase	NA	NA	NA	NA
AYJ07518.1\|966553_968506_-	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	5.8e-87	39.4
AYJ04224.1\|968620_969163_+	DUF4232 domain-containing protein	NA	NA	NA	NA
AYJ04225.1\|969248_970874_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
AYJ04226.1\|970875_971802_+	ABC transporter permease	NA	NA	NA	NA
AYJ04227.1\|971794_972670_+	ABC transporter permease	NA	NA	NA	NA
AYJ07519.1\|972666_974313_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	8.0e-13	28.0
AYJ04228.1\|974302_975061_+	oxidoreductase	NA	NA	NA	NA
AYJ04229.1\|975526_976384_-	HAD-IB family hydrolase	NA	NA	NA	NA
AYJ07520.1\|976896_977949_+	helicase	NA	NA	NA	NA
AYJ04230.1\|977945_979121_+	conjugal transfer protein	NA	NA	NA	NA
AYJ04231.1\|979117_979921_+	hypothetical protein	NA	NA	NA	NA
AYJ07521.1\|979943_980531_+	hypothetical protein	NA	NA	NA	NA
AYJ04232.1\|980549_980750_+	DUF4244 domain-containing protein	NA	NA	NA	NA
AYJ07523.1\|980809_981076_+	pilus biosynthesis protein TadE	NA	NA	NA	NA
AYJ07522.1\|981032_981401_+	helicase	NA	NA	NA	NA
AYJ04233.1\|981397_982435_-	hypothetical protein	NA	NA	NA	NA
AYJ04234.1\|982517_984848_-	DUF1998 domain-containing protein	NA	NA	NA	NA
AYJ07524.1\|985096_985300_+	cold-shock protein	A0A1X9IGI9	Lactococcus_phage	2.0e-14	56.2
AYJ04235.1\|985488_986079_+	hypothetical protein	NA	NA	NA	NA
AYJ04236.1\|986283_989082_+	type I DNA topoisomerase	A0A2K9L5F8	Tupanvirus	8.6e-100	30.7
AYJ04237.1\|989078_990740_-	adenylate/guanylate cyclase domain-containing protein	A0A1B1IWY2	uncultured_Mediterranean_phage	8.4e-18	32.8
AYJ04238.1\|990838_992044_+	DNA polymerase III subunit delta'	NA	NA	NA	NA
AYJ04239.1\|993229_994336_+\|integrase	integrase	A0A220NQQ9	Corynebacterium_phage	1.9e-10	32.2
AYJ07525.1\|994386_996564_+\|transposase	transposase	NA	NA	NA	NA
AYJ04240.1\|996553_996985_+\|transposase	transposase	NA	NA	NA	NA
AYJ04241.1\|997363_997753_-\|transposase	transposase	NA	NA	NA	NA
998240:998255	attR	NA	NA	NA	NA

DBSCAN-SWA_4

2192248 : 2229771

Mycobacterium_phage(50.0%)

capsid,protease,integrase,transposase

attL 2215746:2215774|attR 2227104:2227132

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYJ05154.1\|2192248_2193472_-\|protease	zinc metalloprotease	NA	NA	NA	NA
AYJ07611.1\|2193491_2194715_-	1-deoxy-D-xylulose-5-phosphate reductoisomerase	NA	NA	NA	NA
AYJ07612.1\|2194835_2195090_+	DUF2631 domain-containing protein	NA	NA	NA	NA
AYJ05155.1\|2195949_2196453_-	protein disulfide oxidoreductase	NA	NA	NA	NA
AYJ05156.1\|2196504_2197599_-	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	NA	NA	NA	NA
AYJ05157.1\|2197633_2198569_-	phosphatidate cytidylyltransferase	NA	NA	NA	NA
AYJ05158.1\|2198601_2199159_-	ribosome-recycling factor	NA	NA	NA	NA
AYJ05159.1\|2199280_2200078_-	UMP kinase	NA	NA	NA	NA
AYJ05160.1\|2200409_2200649_+	CsbD family protein	NA	NA	NA	NA
AYJ05161.1\|2200817_2201513_+	DNA-binding response regulator	NA	NA	NA	NA
AYJ07613.1\|2201536_2202475_-	glycerol acyltransferase	NA	NA	NA	NA
AYJ05162.1\|2202570_2203143_-	DUF1942 domain-containing protein	NA	NA	NA	NA
AYJ05163.1\|2203373_2204579_+\|transposase	IS110 family transposase	NA	NA	NA	NA
AYJ05164.1\|2205164_2206004_+	KR domain-containing protein	A0A2N9QUX2	Trichoplusia_ni_ascovirus	1.7e-59	45.3
AYJ05165.1\|2206094_2206508_-	cation transport regulator ChaB	NA	NA	NA	NA
AYJ05166.1\|2206626_2207049_+	MarR family transcriptional regulator	NA	NA	NA	NA
AYJ05167.1\|2207049_2208468_-	amidase	NA	NA	NA	NA
AYJ05168.1\|2208530_2209358_-	elongation factor Ts	NA	NA	NA	NA
AYJ05169.1\|2209371_2210202_-	30S ribosomal protein S2	NA	NA	NA	NA
AYJ05170.1\|2210476_2210980_+	M23 family peptidase	NA	NA	NA	NA
AYJ05171.1\|2211080_2211986_-	tyrosine recombinase XerC	A0A0K2CP59	Brevibacillus_phage	4.1e-19	27.0
AYJ05172.1\|2213113_2214313_+	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
AYJ05173.1\|2214318_2214780_+	DUF4411 domain-containing protein	NA	NA	NA	NA
2215746:2215774	attL	NA	NA	NA	NA
AYJ05174.1\|2215969_2216287_+	hypothetical protein	NA	NA	NA	NA
AYJ05175.1\|2216290_2216656_+	hypothetical protein	NA	NA	NA	NA
AYJ05176.1\|2216753_2217152_+	hypothetical protein	NA	NA	NA	NA
AYJ05177.1\|2217267_2217453_+	hypothetical protein	NA	NA	NA	NA
AYJ05178.1\|2217581_2218145_-	hypothetical protein	NA	NA	NA	NA
AYJ05179.1\|2218817_2219030_-	hypothetical protein	NA	NA	NA	NA
AYJ05180.1\|2219029_2219869_-\|capsid	phage major capsid protein	NA	NA	NA	NA
AYJ05181.1\|2220090_2220336_-	hypothetical protein	NA	NA	NA	NA
AYJ05182.1\|2220574_2220913_-	hypothetical protein	NA	NA	NA	NA
AYJ05183.1\|2220909_2221179_-	hypothetical protein	NA	NA	NA	NA
AYJ05184.1\|2221175_2221460_-	hypothetical protein	NA	NA	NA	NA
AYJ07614.1\|2221499_2222783_-	DUF3631 domain-containing protein	NA	NA	NA	NA
AYJ05185.1\|2222956_2223301_-	hypothetical protein	NA	NA	NA	NA
AYJ05186.1\|2223511_2224924_+\|transposase	IS110 family transposase	NA	NA	NA	NA
AYJ05187.1\|2225214_2225475_-	helix-turn-helix domain-containing protein	A0A2P1CHK7	Mycobacterium_phage	1.8e-15	66.7
AYJ05188.1\|2225751_2226921_-\|integrase	site-specific integrase	A0A1D8EV90	Mycobacterium_phage	1.7e-62	39.2
AYJ05189.1\|2229339_2229771_-\|transposase	transposase	NA	NA	NA	NA
2227104:2227132	attR	NA	NA	NA	NA

DBSCAN-SWA_5

2900828 : 2966679

Corynebacterium_phage(40.0%)

integrase,transposase

attL 2890786:2890805|attR 2971090:2971109

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2890786:2890805	attL	NA	NA	NA	NA
AYJ07662.1\|2900828_2902049_+\|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	2.4e-62	40.3
AYJ05708.1\|2901970_2903077_+\|integrase	integrase	A0A220NQQ9	Corynebacterium_phage	1.9e-10	32.2
AYJ07663.1\|2903127_2905305_+\|transposase	transposase	NA	NA	NA	NA
AYJ05709.1\|2905294_2905726_+\|transposase	transposase	NA	NA	NA	NA
AYJ05710.1\|2906728_2907760_+	hotdog fold thioesterase	NA	NA	NA	NA
AYJ05711.1\|2907859_2909068_+	amidohydrolase	NA	NA	NA	NA
AYJ05712.1\|2909129_2909501_+	hypothetical protein	NA	NA	NA	NA
AYJ05713.1\|2909445_2909748_-	hypothetical protein	NA	NA	NA	NA
AYJ05714.1\|2909749_2911240_-	oxidoreductase	NA	NA	NA	NA
AYJ05715.1\|2911253_2911763_-	oxidoreductase	NA	NA	NA	NA
AYJ05716.1\|2912009_2913977_+	STAS domain-containing protein	NA	NA	NA	NA
AYJ05717.1\|2913973_2915215_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
AYJ05718.1\|2915211_2916360_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
AYJ05719.1\|2916573_2917533_-	alpha/beta hydrolase	NA	NA	NA	NA
AYJ05720.1\|2917826_2919059_+	cytochrome P450	NA	NA	NA	NA
AYJ05721.1\|2919055_2920213_+	NDMA-dependent alcohol dehydrogenase	E3SJ82	Synechococcus_phage	1.2e-34	30.8
AYJ05722.1\|2920220_2922125_-	DUF3533 domain-containing protein	NA	NA	NA	NA
AYJ05723.1\|2922128_2922806_-	hypothetical protein	NA	NA	NA	NA
AYJ05724.1\|2922829_2923447_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
AYJ05725.1\|2923522_2924347_-	KR domain-containing protein	NA	NA	NA	NA
AYJ05726.1\|2924404_2925625_-	cytochrome P450	NA	NA	NA	NA
AYJ05727.1\|2925806_2927303_+	acetyl-CoA carboxylase carboxyltransferase subunit	NA	NA	NA	NA
AYJ05728.1\|2927375_2928449_-	TIGR03857 family LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
AYJ05729.1\|2928412_2928793_-	nuclear transport factor 2 family protein	NA	NA	NA	NA
AYJ05730.1\|2928792_2929914_-	alpha/beta hydrolase	NA	NA	NA	NA
AYJ05731.1\|2929928_2931551_-	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
AYJ05732.1\|2931667_2932681_+	Rieske (2Fe-2S) protein	NA	NA	NA	NA
AYJ05733.1\|2932677_2933307_+	cysteine hydrolase	NA	NA	NA	NA
AYJ05734.1\|2933303_2933936_+	PaaI family thioesterase	NA	NA	NA	NA
AYJ05735.1\|2933944_2935597_+	acyl-CoA synthetase	A0A2K9L3I8	Tupanvirus	7.3e-06	20.7
AYJ05736.1\|2935638_2936481_+	KR domain-containing protein	NA	NA	NA	NA
AYJ05737.1\|2936609_2937812_+	cytochrome P450	NA	NA	NA	NA
AYJ05738.1\|2937834_2939049_+	CoA transferase	NA	NA	NA	NA
AYJ05739.1\|2939103_2940249_+	thiolase family protein	NA	NA	NA	NA
AYJ05740.1\|2940365_2941559_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
AYJ05741.1\|2941559_2942606_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
AYJ05742.1\|2942608_2943439_-	amidohydrolase	NA	NA	NA	NA
AYJ05743.1\|2943435_2945073_-	acyl-CoA synthetase	NA	NA	NA	NA
AYJ05744.1\|2945095_2946298_-	amidohydrolase	NA	NA	NA	NA
AYJ05745.1\|2946317_2947142_-	enoyl-CoA hydratase	NA	NA	NA	NA
AYJ05746.1\|2947453_2947696_+	CsbD family protein	NA	NA	NA	NA
AYJ05747.1\|2947749_2948766_-	dihydrodipicolinate synthase family protein	NA	NA	NA	NA
AYJ05748.1\|2948810_2949608_-	KR domain-containing protein	NA	NA	NA	NA
AYJ05749.1\|2949788_2950592_+	TetR family transcriptional regulator	NA	NA	NA	NA
AYJ05750.1\|2950611_2951502_-	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
AYJ05751.1\|2951733_2952939_+\|transposase	IS110 family transposase	NA	NA	NA	NA
AYJ05752.1\|2952973_2953666_-	hypothetical protein	NA	NA	NA	NA
AYJ05753.1\|2953843_2954665_+	enoyl-CoA hydratase	NA	NA	NA	NA
AYJ05754.1\|2954769_2955582_+	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
AYJ05755.1\|2955572_2956379_+	enoyl-CoA hydratase/isomerase family protein	NA	NA	NA	NA
AYJ05756.1\|2956378_2957839_+	AMP-dependent synthetase	NA	NA	NA	NA
AYJ05757.1\|2957828_2959403_+	long-chain fatty acid--CoA ligase	NA	NA	NA	NA
AYJ05758.1\|2959395_2960952_+	long-chain fatty acid--CoA ligase	Q75ZG1	Hepacivirus	2.8e-15	23.5
AYJ05759.1\|2960927_2961290_-	hypothetical protein	NA	NA	NA	NA
AYJ05760.1\|2961363_2961672_-	hypothetical protein	NA	NA	NA	NA
AYJ05761.1\|2961672_2962329_-	glutamine amidotransferase	NA	NA	NA	NA
AYJ05762.1\|2962405_2963359_+	AraC family transcriptional regulator	NA	NA	NA	NA
AYJ05763.1\|2963355_2964042_-	GntR family transcriptional regulator	NA	NA	NA	NA
AYJ05764.1\|2964048_2965242_-	acyl-CoA dehydrogenase	NA	NA	NA	NA
AYJ05765.1\|2965473_2966679_+\|transposase	IS110 family transposase	NA	NA	NA	NA
2971090:2971109	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP028731

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CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection