CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP033073	Streptomyces sp. Z022 chromosome, complete genome	18 crisprs	DEDDh,WYL,csa3,cas3,cas6e,cas5,cas7,cse2gr11,cas8e,cas4	0	31	3	0
CP033072	Streptomyces sp. Z022 plasmid unnamed1	0 crisprs	NA	0	0	0	0

1. CP033073

CRISPR-Cas detection and classification

Crispr_ID: CP033073_2

• CRISPR_ID: CP033073_2
• CRISPR_location: 480140-480220
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP033073_2

Consensus_repeat	Method
AACGGCCGAACCGAAGCCGACGCAGC	CRISPRCasFinder

spacers of CP033073_2

>2.1|480166|29|CP033073|CRISPRCasFinder
GACCCAAGCCCCCCTGACGACAGGCGCGG

CRISPR arrays and Neighbor proteins around CP033073_2

CRISPR arrays

The CRISPR arrays of CP033073_2

>merge|CP033073|2|480140-480220|CRISPRCasFinder
AACGGCCGAACCGAAGCCGACGCAGCGACCCAAGCCCCCCTGACGACAGGCGCGGAACCGCCGAACCGAAGCCGACGCAGC

>CP033073|2|2|480140-480220|CRISPRCasFinder
AACGGCCGAACCGAAGCCGACGCAGC	GACCCAAGCCCCCCTGACGACAGGCGCGG
AACCGCCGAACCGAAGCCGACGCAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN38013.1|490584_492078_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN43437.1|468016_468484_-|flavodoxin-family-protein	unknown	unknown	gnl|CDD|223728
CP033073.1|AYN38008.1|481878_484449_+|diguanylate-cyclase	unknown	unknown	gnl|CDD|369272
CP033073.1|AYN38016.1|495114_495852_-|beta-phosphoglucomutase-family-hydrolase	unknown	unknown	gnl|CDD|213673
CP033073.1|AYN38005.1|476543_477908_+|pyridine-nucleotide-disulfide-oxidoreductase	unknown	unknown	gnl|CDD|215457
CP033073.1|AYN43438.1|470852_471539_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38001.1|468460_469249_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
CP033073.1|AYN38004.1|472354_474424_-|DUF1996-domain-containing-protein	unknown	unknown	gnl|CDD|370451
CP033073.1|AYN38002.1|469255_470584_-|triacylglycerol-lipase	unknown	unknown	gnl|CDD|367570
CP033073.1|AYN38010.1|487397_489233_-|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl|CDD|225922
CP033073.1|AYN38015.1|492760_495118_-|glycoside-hydrolase-family-65-protein	unknown	unknown	gnl|CDD|224471
CP033073.1|AYN38006.1|478350_479562_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38009.1|484680_487305_+|GAF-domain-containing-protein	unknown	unknown	gnl|CDD|369272
CP033073.1|AYN38014.1|492249_492633_+|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl|CDD|367747
CP033073.1|AYN43439.1|475351_476353_+|peptidoglycan-endopeptidase	unknown	unknown	gnl|CDD|366353
CP033073.1|AYN38011.1|489481_489691_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38003.1|471563_472202_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|273701
CP033073.1|AYN38007.1|479721_480012_+|DUF1232-domain-containing-protein	unknown	unknown	gnl|CDD|377712
CP033073.1|AYN43440.1|480305_481388_-|hypothetical-protein	unknown	unknown	gnl|CDD|237171
CP033073.1|AYN38012.1|489794_490280_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN43437.1|468016_468484_-|flavodoxin-family-protein	gnl|CDD|223728	COG0655, WrbA, Multimeric flavodoxin WrbA [General function prediction only].	4.16107e-10
CP033073.1|AYN38008.1|481878_484449_+|diguanylate-cyclase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	9.90505e-49
CP033073.1|AYN38016.1|495114_495852_-|beta-phosphoglucomutase-family-hydrolase	gnl|CDD|213673	TIGR02009, Hypothetical_protein_Rv3400/MT3508/Mb3433., beta-phosphoglucomutase family hydrolase. This subfamily model groups together three clades: the characterized beta-phosphoglucomutases (including those from E.coli, B.subtilus and L.lactis, TIGR01990), a clade of putative bPGM's from mycobacteria and a clade including the uncharacterized E.coli and H.influenzae yqaB genes which may prove to be beta-mutases of a related 1-phosphosugar. All of these are members of the larger Haloacid dehalogenase (HAD) subfamily IA and include the "variant 3" glu-asp version of the third conserved HAD domain (TIGR01509).	1.0235e-52
CP033073.1|AYN38005.1|476543_477908_+|pyridine-nucleotide-disulfide-oxidoreductase	gnl|CDD|215457	PLN02852, PLN02852, ferredoxin-NADP+ reductase.	4.26819e-129
CP033073.1|AYN38001.1|468460_469249_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	9.74014e-22
CP033073.1|AYN38004.1|472354_474424_-|DUF1996-domain-containing-protein	gnl|CDD|370451	pfam09362, DUF1996, Domain of unknown function (DUF1996). This family of proteins are functionally uncharacterized.	7.45376e-22
CP033073.1|AYN38007.1|479721_480012_+|DUF1232-domain-containing-protein	gnl|CDD|377712	pfam06803, DUF1232, Protein of unknown function (DUF1232). This family represents a conserved region of approximately 60 residues within a number of hypothetical bacterial and archaeal proteins of unknown function.	0.000998935
CP033073.1|AYN38010.1|487397_489233_-|glycoside-hydrolase-family-15-protein	gnl|CDD|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	4.97362e-130
CP033073.1|AYN38015.1|492760_495118_-|glycoside-hydrolase-family-65-protein	gnl|CDD|224471	COG1554, ATH1, Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism].	0
CP033073.1|AYN38009.1|484680_487305_+|GAF-domain-containing-protein	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	4.64487e-53
CP033073.1|AYN38014.1|492249_492633_+|BlaI/MecI/CopY-family-transcriptional-regulator	gnl|CDD|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	4.45666e-27
CP033073.1|AYN43439.1|475351_476353_+|peptidoglycan-endopeptidase	gnl|CDD|366353	pfam00877, NLPC_P60, NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins.	6.47708e-23
CP033073.1|AYN38003.1|471563_472202_-|GNAT-family-N-acetyltransferase	gnl|CDD|273701	TIGR01575, rimI, ribosomal-protein-alanine acetyltransferase. Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification].	3.77184e-08
CP033073.1|AYN38002.1|469255_470584_-|triacylglycerol-lipase	gnl|CDD|367570	pfam03583, LIP, Secretory lipase. These lipases are expressed and secreted during the infection cycle of these pathogens. In particular, C. albicans has a large number of different lipases, possibly reflecting broad lipolytic activity, which may contribute to the persistence and virulence of C. albicans in human tissue.	1.27403e-83
CP033073.1|AYN43440.1|480305_481388_-|hypothetical-protein	gnl|CDD|237171	PRK12678, PRK12678, transcription termination factor Rho; Provisional.	1.617e-05

Protein sequences

>CP033073.1|AYN38007.1|479721_480012_+|DUF1232-domain-containing-protein
MDTSGTLLLVIAVVAAAALLALAVGLLVRLVRTRRTLRQAGLPTGPRWVFWGAVAYLVLPTDLLPDPVYLDDIGVLLLALRSLRAARPLPPGPYEP
>CP033073.1|AYN38006.1|478350_479562_+|hypothetical-protein
MSNSAGDRATIPQSVWAARGRHTGPDPEDVVRRILHRREESGDIDDFAEPPAGEDPAGRIFEARWRAAGTVTVRARLTLVPHPSRPQEHEWRLVAEAERPWDDTWPSPATLFWPGGGVDETGDGSWDHHATVPGLPLRQANALPPDDKEMRRRLRDAARESWCVNVVVHEAMTPDERGRLPLTRLLPPGLRHRVVEHRAAPQQLRAVNWALKDLGVEVPRGGAVLLPPDPAPKDYDGREHSVRNVFLDGSEPAELVAALRHFTAQSRPMPQGAEEALTDLRENWTLRTLKEELERERRLVAMYAEALEAMTKSRDLYKQAAEQALEALSAYRDVPAPTLPQQQRPTVRTPVALHQLTRTFERLKLTAKGRQRPESAASASLDGTPADGAAVDGRAVDGKVEDE
>CP033073.1|AYN38005.1|476543_477908_+|pyridine-nucleotide-disulfide-oxidoreductase
MPRPLRVAIVGAGPAGIYAADALLKSEVAADPGVSIDLFERMPAPFGLIRYGVAPDHPRIKGIITALHQVLDKPQIRLFGNVDYPTDISLDDLRAFYDAVIFSTGAMADRDLSIPGVELDGSYGAADFVSWYDGHPDVPRSWPLEAEKVAVLGVGNVALDVARILAKTADELLPTEIPPNVYDGLKTNKAVEIHVFGRRGPAQAKFSPMELRELDHSPNIEVIVDPEDIDYDAGSIGTRRGNKQADMVAKTLEKWAIRDVGNRPHKLFLHFFESPAEILGEDGKVVGLRTERTALDGTGNVKGTGEFKDWDVTAVYRAVGYLSEKLPKLPWDIDSGTVPDKGGRVIEEGGTPLRSAYVTGWIRRGPIGLIGHTKGDANETVANLLDDYANGRLDTPATPEPEAVDAFLAGRDVRFTTWEGWYRLDAAERALGEPQSRERVKIVEREDMLRASGA
>CP033073.1|AYN43439.1|475351_476353_+|peptidoglycan-endopeptidase
MGELMGGPVAAGAVTGGAVGWPAAMPAVGRAAPPDTALPQPVTGYPELITVESTGRSTPEPATTGGSLSLPGFAEQASAGVGAAETALLPAVAPPTAQANRVQTPRTLPGAAPGRPSPTVTKGDSLRKLTSARELLTRYTSPLASAAGTVQPAPARTTWNTGTQPGPGTTPTAAPRVPVMPEAPSTAFGHLGSLVPPTPASTLAPAPLPGTDSRVLRAAKAIAFARAQVGRPCVWGATGPGSYDCSSLVQAAWRAAGVTLPRAAHQQALAGTPVTLAVAEPGDLVLFFDDDRHVGLYVGDGMMVHAPGPGSTIREESVYGAGEAAIHRVVRPA
>CP033073.1|AYN38004.1|472354_474424_-|DUF1996-domain-containing-protein
MLGGAGLAAANVYASASEGWGDGSGTDSTGRVLSTGMATIDCPDVGSRLTAVPDTARPDVDRELALLDQQTAAAYRQLHQYGQSGGQGTGPNADTIMNPLKGKRSAAIGRITDTLDRAGEHPQGLDDLAACTLRPGDTGRPTATPSGTGQGQDGTGQAQNGAGQAGNGPVVSDYADITAVQPDAPAPSPGSDASRGTFTSDCGVNANGLFNSDNVIVAPGVSNGAHHFHDYIGNQGNNAFAGDDDLAKAATSCVDQGDRSTYYWPVLRLQNGKQERDAGAPGGGTEGNAGQIVTPKAVTLTFVGNPRGKVTAMPRLLRIITGDAKAFVNGPGNANASWSCTGHEDRQLKDKYPLCPQGSDVVRTFRFQSCWDGRNIDSANHRTHVAFATVDGSCPAGFRPIPQLVQRIVYGVAAPSLTDGGRTVPLFAVDSFPEQLHKPVTDHGDFINVFDEDLMREMVDCINSGRTCGPSDGTGTGNGNGNGNGNGNGNEGGSGSGGGGSGSGTTVTPTATSGSPATAAPGGGTTAEPGGNTATKAGGDTSTEPGQDTATEPGAGATSAPRAPASRPGEAPRTEVTTSPARTTKRDGAGAPGGDDRAGKAAPGGSAPSRATSARPAPSASPSAPAPAPSASDQATAAGYVPPVAAQAPPQTTGGGLAETGAHLWPAAIGTLLALSGLFMLIRARRLPY
>CP033073.1|AYN38003.1|471563_472202_-|GNAT-family-N-acetyltransferase
MPSLRPHPAPAIRPYRPADREAVADVCVRTAHNGGDSRAIYPDPRLMPALFAEPYCRFDPDLAFVLDDGTGRAVGYVVGTADTERFVRDLRRSWIPRLAGRYPKPTAPPRTPTEEMIHLLHQPERMLVPELAGFPAHLHIDLLPDWQRRGYGRGLLHTFLAALSGQGVRAVHLGMVTANTAARAFYDRLGFHVIPVADAGSLTYLGRETTVR
>CP033073.1|AYN43438.1|470852_471539_+|hypothetical-protein
MAVGTAVGTALLATALSGCAGSGGTDGKGRPGASGTPASASASASAKASPSGGTIGAVGSACELPVSFGVARHWKAKSIDAAKELSEASGKPDDDLGGALADSLLRQGPVTAACEIDAKPAGNIGFLRVWTGRTGDADAGGVLRAFVAAEDNVSKAKYHSFTTGGGVPAVEVEYLYTSKILEETKKESAFAVSTPDGPVVLHLGGMDTEEHEAMRPAYDLAKRTLGLA
>CP033073.1|AYN38002.1|469255_470584_-|triacylglycerol-lipase
MSVRTRVPAALAIAVAACLGAQTAAALPATATDTVVSRGVTIPAFYTPPTALPAADGTLVRSERLPLALSLPGLDGPLPGRATRLMYKSTDSAGQPVAVTGAYLEPAAAWKRGGPRPLVAVAPGTMGQGDQCAASLGLEHPLTLNGRTVSVGYEDLAIYRLLAEGVAVVVTDYAGLGATDRLHTYVNRLDGAHAVLDAVRAARNLAGASVTEVSPVGLYGYSQGGGATAAAAELQPSYAPDVTLAGTYSGAPPADLAKVTEAIDGSDLAGALGWAVNGFLESDPALRPIADRHLNAAGKAALADLSTMCVGDAILSYNSALSTAWTTDGSSLADVVAAEPALRDFLDRQRIGTGRPAGPVRVATGINDDLVPHAQARRLAVDWCRKGTDVTYVPVVAPQLGRALLNHFAPLLADQGDAVDWLTDRLAGRAAGSTCRLLPLQP
>CP033073.1|AYN38001.1|468460_469249_+|class-I-SAM-dependent-methyltransferase
MDDQQGRHAPHPAVRLPLLANAGCRQASPAPARGRTLSGSPYAATEGDGVAEDDRRAPAAEVFDALGVAYEEAFAGSEPHRASLRWLLERLPPGGRVLDVGSGTGRPTAQTLTEAGHRVLGVDVSRVMTELAARQVPAADFRLADIRELPLEEASFDAVCAYFPLLQMSRAEQAAVVAKLARAVRPGGPAALATVPLDGEDVEGHFMGQPVRVTSFAAGAFRELVAGAGLTVLAEDHAVFTPAHPDAVPEPQLFLHARREGP
>CP033073.1|AYN43437.1|468016_468484_-|flavodoxin-family-protein
MPTLLIVHHTPSPNCQALLEAVVSGATTPEIEGVRVVRRAALSATASDVLEADGYLLGTPANLGYMSGALKHFFDQIYYPCLDETRGRPFGYYVHGGNDVTGAVRAVEAVTTGLAWRRAADAVTVTGEPGKDDTQACWELGATLAAGLMPDVPDR
>CP033073.1|AYN43440.1|480305_481388_-|hypothetical-protein
MRDLVHAAVADRPLEDVVRLITLLEESPEHARTTADALHAVGVDRSVEDVTRLVALLTKPPRGSDSADEAIRAAAEHRPLEDVSRLMQLLHRNPVEPHCGEAVVRAVAEHRPVEELAELIGRLAADRRSRERPLPEPAPPGAADPRPTPGTRAPGPAPGGDGRPAGDRPTEERAADQRPSKREPVGKPAAGEQKNPAGKRTAGERRPGGRRQGERQDGNRAGDGRGPGSQAWAARGAAPLVLLCGAAHAPRYWAGLPQGVLGATLLASALCGLLALAMTARAAPARLVAATAAAGVTAVLATGELLGGRFGMPGPARLGAATLAPPWVAGMTAAVAALAALTIVLTTLTAGTTRPADGGR
>CP033073.1|AYN38008.1|481878_484449_+|diguanylate-cyclase
MTGSGERAVRTRARLAALLADASTCAVGAADGRVAGVYLRSGTPGTLRLAVLVGLPGALFRPWWRLHVGRPFPVADAYRLGVPVVLPNATETMRRYPQFAAGLPFPFGSVHVPVPGGTEPLGVLTVLRPSVADTLDDLLDRDQLAQLAEGLGAGLRALADGDESTVSWDGEPLGVRPPASQAARAAVGRFTWDPATSEVLADDRLHALLGLRPGEFTGTEAALADAVAPADAHRILAALRDAAAGTPPGTPLDLRSRDGTPRLLDLWPASGGASGTAGRDAVRGLVRGVVFDPGPGASADGAADLLPQGVFCLDRLGLIVYANPAAARFAGREREWLLGRALWEAMPWLSGPPYDDHLRGALLAPDPVHFHARRPAGDRGEPGEGEWLAVSIHPGPDLLTCTLVPASRMETALGEVPEAHVPEDTVASGHSLAPLYRPIALAIALTDAVTARQVSAVVMQELLPAFGGRRLAIYLLQERHLYLAWETGFPQGFLASFEGVGLDAHLPGVETLTTGRPLFFESMQQLTAAYPGIALDADEGARAFLPLIASGRPVGSCILGFEGSRGFSTEERTVLTALAGLIAHAMERAQRYDSEAALARGLQQALLPRRLSVHPRVETAGRYLPGTQGMDVGGDWYDVVGAGDGLALVIGDVQGHGVQAAATMGQLRSAVRAFALGDRPPDEVLSGTNLLLIDLDPGQFASCCYLRLDPVTGRTRIARAGHPPPLLRAPDGSTRVLDIPGGVVLGVDPAARYPVTEVLLEPDAILALYTDGLVERPGADIDDGITALRLALAQAGANAGRPGRRSLTGVADQLTANARHATDRPDDVALLLAARRPAPAPHDRPPASTPPPPPHG
>CP033073.1|AYN38009.1|484680_487305_+|GAF-domain-containing-protein
MLRSAVSGRSVAGQVFLLQVVIVLLLVVSAVVAQVLQVRHDSDLEATNRSLAVAETFANAPGTAAALRSPDPTAVLQPRAEATRKATGVDFVVVMNTDGVRYTHPRTDRIGRRFVGTIAPALAGGTVTEHITGTIGPLVQVVVPVRDRAGKVAGLVSAGITTAHVGGAADQQLPLLLAAAAAALALATAGTALVSRRLLRQTRGLGPYEMTRMYEHHDAVLHAVREGVLIVGGDGRLLLANDEAHRLLDLPEDAERRHVLELGLDDETAGLLASGRIATDEVHLVKDRLLAVNQRPTDLRGGPAGSVTTLRDSTELRAVSGRAEVARERLNMLYDAGVGIGTSLDVTRTAEELAQLAVPRFADFATVDLFDAVLSGEEPRPGTALRRAACAGIRKDAPLYPAGDRIRFVPTSPQARSLVTGQSLVEPRLRTSPGWRAQDLERSDQVLAYGIHSLIAVPLRAGSLVLGVATFWRSEKPQPFDTEELALAEELVARAAVSIDNARRYTREHSMAVTLQRSLLPRTLPEQGALDIAYRYLPAQAGVGGDWFDVLPLSGARVALVVGDVVGHGLHAAATMGRLRTAVHNFSSLDLPPDELLALLDELVGRIDQDETPATGAAVVTGATCLYAIYDPVSRRCSMARAGHPPPALARPDGSVEFLDLPAGPPLGLGGLPFETAELELPEDSRLVLYTDGLVEDRERDIDEGLGLLRDALLRTPGASPEDTCRTVLDRLPARPSDDVALIVARTRVLGGDRVAQWQVPSEPAAVSEVRASVTRELSGWGLEDLAFTTELILSELVTNAIRYGRGPIGVRLLRDRTLICEVSDRSTTSPHLRYAGSTDEGGRGLFLVAQLAERWGTRYTPQGKVIWAEQPLP
>CP033073.1|AYN38010.1|487397_489233_-|glycoside-hydrolase-family-15-protein
MAETPFPEDAAPGRRYLPIADHGLIGDLRSVALVGTDGTIDWYCCPSFDAPSVFAAILDAERGGRFELAATVPARTKQFYFPDTNVLITRFFTEDGVGEVQDFMPVGTEGSETGRHRLIRRVVCVRGTVPFRALVAPRFDYGAAPHTLRALDGMVLFESPDLSLTLTSTTALEYDDRDAWADFKLDEGDSTVFALDQAGARIAPRGCAHAEAEHEFTATVAYWRRWLHQSRYRGRWREMVHRSALTLKLLTYAPTGAIIAAPTTSLPEQLGGERNWDYRYVWVRDAAFCVYALLRLGFSGEAEAFMRFVTTHISPGCGDGTGPLQIMYGIDGRADLPERELPHLEGHQGSAPVRVGNAAAGQLQLDIYGALIDSIYLYDTWAQPISSGQWDDVCQLVDWVCDHWDQPDEGVWETRGGRKNFLYSRLMCWVAIERAIRLANRRGLPADLTRWRRSRDTVYRRIMDRGWSERRGAFVQYEGGDVLDASLLMMPLAKFIAPTDPKWLSTLDALTDDLVSDSLVYRYDPQASPDGLRGDEGTFSICSFWYVEALVRAGRLDEARLAFEKMLTYANHLGLYAEEIGRTGRQQGNFPQAFTHLSLISAAFNLDRALG
>CP033073.1|AYN38011.1|489481_489691_+|hypothetical-protein
MSTSTPEESRSSSDDVCTPDALLHSAPPRDVTPEDLVMAAGRDVTPKNLDWARQKLESEGSAAVEKLLP
>CP033073.1|AYN38012.1|489794_490280_-|hypothetical-protein
MSDRSEQTPMADDAYQPTGTNEEQEDAAPLDLQDAVGERTYDDILDEGYSPPERPLGVTKHGITAAEQHEGETLDERLGQEVPDVTPPAGDEIGDLPGGAGEPVDSEAGETRAGRLVAPDEGAHADTVKEEIAEDVGIDGGAAGAEEAAVHVIPDDTVLPE
>CP033073.1|AYN38013.1|490584_492078_-|hypothetical-protein
MTGSTDAQHAGARRAVPPVTAGGRTRARATAPLAAVAAVFTLVQLLLVGPGTGLGWDETVYVSQVGAHAPASFFSAPRARGVSLLVAPVAAWSSSTVLLRIYLAVLSGLALYLALRAWRDLFPVRVLALAGALFASLWVTLFYGPQAMPNYWVAVGALTAVACFLRAGAAGAGTDRAALAGLAASAALMAWMRPTDAVWAALPLLALGAARRHRRALPVLLTGLAAGAAEWVIEAYVRYGGLVRRLADGSAIQGGLGWHLAVVDQLRSLGGRTLCRPCTGGPPHPALTAWWFVLPLLAALGLVVAVRARRPAATALPLACAATAAFPYLFLIGYAAPRFLLPAYALVAVPVADALVHLTTVPRPSRRPAVVTLVCAGLAAHLAVQLAILGHTAGNTAAAHRSWSRTAAELHRRGIRPPCLVTGDDALPVAYRAGCSSAATAGPNANATDDGITRTARRVPVAALVPAEASPPRYARAWTSVPWGGGRLYYVVPGPRR
>CP033073.1|AYN38014.1|492249_492633_+|BlaI/MecI/CopY-family-transcriptional-regulator
MAGTGARGGAGRRRAGALESEVLAALWAGERPLTPAEVQAGIGGGLAYNTVHTILKRLHDKGLVVRDADGRRGAYRPAMNAAELTAQAMHEALDRGPDPIAALRHFVTGLSPEHERALRELLTPDDD
>CP033073.1|AYN38015.1|492760_495118_-|glycoside-hydrolase-family-65-protein
MITERSYAVEPWTVRETTLDLDVLAQSESVFALSNGHVGWRGNLDEGEPHGLPGSYLNGVHEVHPLPYAEAGYGYPESGQTVINVTNGKVLRLLVDDEPFDLRYGRLVAHERVLDLRRGVLERTCEWTSPAGSTVRVRSTRLVSLTQRAVAAVAYEVEAVGSRSRVVIQSELVANESLPQSDGDPRAARALKSPLEQEDGFAAGNRLRLVHRTRRSGLRVAVAADHVVTGPDRTTTRSESGIDVARLTVTSVLEPGQTLRVEKLVAHGWSGARSLPAMADQVDAALAAAGHDGWQGLLSDQRACLDDFWARADVEVEGDEEIQQAVRFALFHVLQAGARAEQRAIPAKGLTGSGYDGHAFWDTEMFVLPVLTHTAPAAVAEALRWRYNTLDEARERAAQLGLAGAAFPWRTIAGPEGSAYWPAGTAAFHVNADVADAVVRYVEATGDTAFERETGVELLVETARLWRSLGHHDRHGVFHLDGVTGPDEYSAVADDNTYTNLMARQNLRAAADAVERHPREARRLGVDEEESAVWRDAADAMHLPYNEELAVHEQHAGFTRYQRWDFAGTRADQYPLLLHFPYFDLYRKQVVKQADLVLAMYTCADYFEQEYDEEQIARNFAYYEPLTVRDSSLSACCQAVIAARTGHLDLAHAYTTEAALMDLHDLEHNTRDGLHIASLAGTWMALVAGFGGMRRDGDRPRFAPRLPERLSRLAFHVQFRGRRLRVEIGADKATYALLDGPPLTIRHHGESLTISTDEPAVRAIPPMVRRAAPEQPAHRAPNGDG
>CP033073.1|AYN38016.1|495114_495852_-|beta-phosphoglucomutase-family-hydrolase
MTQLGLPDTIQACLFDLDGVVTKTAVVHAAAWKETFDALLRAYDGEQGRPFEDADYDEYVDGRPRADGVRAFLDSRGIHLPEGGPDDPPDARTVHGVGNRKNELLLERIRTGGVEAYEGTLRYLEAVRAQGLRTAIVSSSANCQDVLRAVGAEHLFDTRIDGVVAAERSLPGKPNPDTFLAAARDLGVEASRAAVFEDALAGMDAGRAGGFGYVVGVDRVGQTDALYKHGADTVVRDLAELGGRR

Crispr_ID: CP033073_3

• CRISPR_ID: CP033073_3
• CRISPR_location: 964090-964187
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP033073_3

Consensus_repeat	Method
CGGGGCCGGGGCGGCACGGGTGGTCC	CRISPRCasFinder

spacers of CP033073_3

>3.1|964116|46|CP033073|CRISPRCasFinder
TTCCCGGGCTCGACTCGGGAGACCGCCGCCCCCACCGGCGCGGGAG

CRISPR arrays and Neighbor proteins around CP033073_3

CRISPR arrays

The CRISPR arrays of CP033073_3

>merge|CP033073|3|964090-964187|CRISPRCasFinder
CGGGGCCGGGGCGGCACGGGTGGTCCTTCCCGGGCTCGACTCGGGAGACCGCCGCCCCCACCGGCGCGGGAGCGGGGCCGGGGCGGCACGGGTCGTCC

>CP033073|3|3|964090-964187|CRISPRCasFinder
CGGGGCCGGGGCGGCACGGGTGGTCC	TTCCCGGGCTCGACTCGGGAGACCGCCGCCCCCACCGGCGCGGGAG
CGGGGCCGGGGCGGCACGGGTCGTCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN38281.1|969795_971334_+|amino-acid-permease	unknown	unknown	gnl|CDD|273331
CP033073.1|AYN38271.1|954571_955171_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
CP033073.1|AYN43483.1|972657_974037_-|MFS-transporter	unknown	unknown	gnl|CDD|129794
CP033073.1|AYN38274.1|960264_960804_-|oxidoreductase	unknown	unknown	gnl|CDD|236910
CP033073.1|AYN38276.1|961850_963728_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
CP033073.1|AYN38279.1|966980_968411_-|carbohydrate-kinase	unknown	unknown	gnl|CDD|198361
CP033073.1|AYN38272.1|957165_959235_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	unknown	unknown	gnl|CDD|224446
CP033073.1|AYN38283.1|974077_975988_-|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl|CDD|225922
CP033073.1|AYN38282.1|971522_972614_+|mechanosensitive-ion-channel-family-protein	unknown	unknown	gnl|CDD|366370
CP033073.1|AYN38270.1|953352_954153_-|DNA-binding-response-regulator	unknown	unknown	gnl|CDD|225818
CP033073.1|AYN38275.1|960876_961737_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38269.1|952732_953113_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38278.1|965568_966984_-|FAD/NAD(P)-binding-oxidoreductase	unknown	unknown	gnl|CDD|223652
CP033073.1|AYN38280.1|968643_969642_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38273.1|959269_960268_-|xanthine-dehydrogenase-family-protein-subunit-M	unknown	unknown	gnl|CDD|224238
CP033073.1|AYN38277.1|964339_965572_-|FAD-binding-protein	unknown	unknown	gnl|CDD|273584
CP033073.1|AYN43482.1|955314_956064_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
CP033073.1|AYN38285.1|976474_976945_-|SHOCT-domain-containing-protein	unknown	unknown	gnl|CDD|378276
CP033073.1|AYN38268.1|950982_952701_-|cation-acetate-symporter	unknown	unknown	gnl|CDD|271374
CP033073.1|AYN38284.1|976009_976441_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN38281.1|969795_971334_+|amino-acid-permease	gnl|CDD|273331	TIGR00907, Choline_transport_protein, amino acid permease (GABA permease). [Transport and binding proteins, Amino acids, peptides and amines].	6.88184e-114
CP033073.1|AYN38271.1|954571_955171_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.42038e-05
CP033073.1|AYN43483.1|972657_974037_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	8.15945e-34
CP033073.1|AYN38274.1|960264_960804_-|oxidoreductase	gnl|CDD|236910	PRK11433, PRK11433, aldehyde oxidoreductase 2Fe-2S subunit; Provisional.	3.22547e-78
CP033073.1|AYN38276.1|961850_963728_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.21254e-164
CP033073.1|AYN38272.1|957165_959235_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit	gnl|CDD|224446	COG1529, CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion].	2.80429e-174
CP033073.1|AYN38283.1|974077_975988_-|glycoside-hydrolase-family-15-protein	gnl|CDD|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	2.38687e-110
CP033073.1|AYN38282.1|971522_972614_+|mechanosensitive-ion-channel-family-protein	gnl|CDD|366370	pfam00924, MS_channel, Mechanosensitive ion channel. Two members of this protein family of M. jannaschii have been functionally characterized. Both proteins form mechanosensitive (MS) ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	1.19641e-48
CP033073.1|AYN38270.1|953352_954153_-|DNA-binding-response-regulator	gnl|CDD|225818	COG3279, LytT, Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms].	2.11103e-53
CP033073.1|AYN38279.1|966980_968411_-|carbohydrate-kinase	gnl|CDD|198361	cd07786, FGGY_EcGK_like, Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases. This subgroup is composed of mostly bacterial and archaeal glycerol kinases (GK), including the well characterized proteins from Escherichia coli (EcGK), Thermococcus kodakaraensis (TkGK), and Enterococcus casseliflavus (EnGK). GKs contain two large domains separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The high affinity ATP binding site of EcGK is created only by a substrate-induced conformational change, which is initiated by protein-protein interactions through complex formation with enzyme IIAGlc (also known as IIIGlc), the glucose-specific phosphocarrier protein of the phosphotransferase system (PTS). EcGK exists in a dimer-tetramer equilibrium. IIAGlc binds to both EcGK dimer and tetramer, and inhibits the uptake and subsequent metabolism of glycerol and maltose. Another well-known allosteric regulator of EcGK is fructose 1,6-bisphosphate (FBP), which binds to the EcGK tetramer and plays an essential role in the stabilization of the inactive tetrameric form. EcGK requires Mg2+ for its enzymatic activity. Members in this subgroup belong to the FGGY family of carbohydrate kinases.	3.11582e-154
CP033073.1|AYN38278.1|965568_966984_-|FAD/NAD(P)-binding-oxidoreductase	gnl|CDD|223652	COG0579, COG0579, Predicted dehydrogenase [General function prediction only].	5.63297e-101
CP033073.1|AYN38273.1|959269_960268_-|xanthine-dehydrogenase-family-protein-subunit-M	gnl|CDD|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	4.69379e-81
CP033073.1|AYN38277.1|964339_965572_-|FAD-binding-protein	gnl|CDD|273584	TIGR01372, sarcosine_oxidase_alpha_subunit, sarcosine oxidase, alpha subunit family, heterotetrameric form. This model describes the alpha subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Mesorhizobium loti and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members are share the same function. The model is designated as subfamily rather than equivalog for this reason.Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines].	1.39518e-23
CP033073.1|AYN43482.1|955314_956064_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	3.82242e-17
CP033073.1|AYN38285.1|976474_976945_-|SHOCT-domain-containing-protein	gnl|CDD|378276	pfam09851, SHOCT, Short C-terminal domain.	2.88313e-05
CP033073.1|AYN38268.1|950982_952701_-|cation-acetate-symporter	gnl|CDD|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	3.54853e-61

Protein sequences

>CP033073.1|AYN38276.1|961850_963728_-|ABC-transporter-ATP-binding-protein
METTAWTQLHSVMNAQSERRPLARATLRRIAAFARPHRAGIVRFVLLGVVTALLAVATPVLAGRVVDAIVAGHDSRTVVRLSLLIGLVALVEAGLGILGRRLSATLGEGLILDLRTAVFDHVQRMPVAFFTRTRTGALVSRLNNDVIGAQRAFANTLSGVVSNLVTLLLTLAVMLTLSWQITLLALVLLPVFVLPARRMGRRMARMQREAATLNAAMGTRMTERFSAPGATLVKLFGRPEEESAEFAARAREVRDIGVRTATAQSVFITSLTLVSALALALVYGLGGWFALRGTLEPGAVVSLALLLTRLYAPLTALAGARVEVMSALVSFERVFEVLDLKPLIEEKPDAREVPEGPVAVEFEDVRFAYPSADQVSLASLEEVAALDTRGGTEVLHGISFRAEPGRTVALVGSSGAGKSTIAQLLPRLYDVDAGAVRIGGTDVRDVTAASLRATLGMVTQDGHLFHDTVRANLLLARPDATDDDLWDALGRARLADVVRSLPDGLDTVVGERGYRLSGGERQRMTIARLLLARQRVVILDEATAHLDNTSEAAVQEALTEALEGRTAVVIAHRLSTVRAADQILVVESGRIVERGTHEELLAAGGRYAELHRTRFARRDETVPTV
>CP033073.1|AYN38275.1|960876_961737_-|hypothetical-protein
MSKTGVGSAVAALVLAAGLTGCGSDDGDGKGGDTQARPSATPPARAVQDAYRRTVAADTAKIAVTSKVVAEGQAVTARGSGVAGLKDGTSRVTLTSRGATVEQRVVDGVVYQKPSGGKHASVPGGKTWAKIDLKRLAQRGSAGRSQVSDPAEPVRYLRNVGSEDVTRVGTQNLDGTRTTHYRVSVPLSALSSGNAAQEREPRGQLGKSTLPVDLWLDEQGRLRQESVRLTLHPLAHRTPGRENTAVTSTTVLRLSDYGTDARVSAPPARDTADVTGKVAGAGAADG
>CP033073.1|AYN38274.1|960264_960804_-|oxidoreductase
MTSAQEPGHHSEVTLRVNGKPHTVLVDHRRVLLDVLREDLDLTGSKKGCDQGQCGACTVLVDGRRLNSCLLLAVTLDGREVTTVEGLGGDGEQPHPLQRAFLDRDAFQCGYCTPGQLCSAVGMLAEAAAGHPSHVTDPAAPAGPPVPLGRPEIRERMSGNLCRCGAYPRIVEAIEDVIE
>CP033073.1|AYN38273.1|959269_960268_-|xanthine-dehydrogenase-family-protein-subunit-M
MTGFGYLRPAGLQEAVEAYAAHPGARYLAGGTNLVDLLKLGVERPALLIDIGRRLPLDTVEELPDGSLRVGATVRNSDLAADPRVRNRYPALSQALLAGASAQLRNAATTGGNLLQRTRCPYFQDLDKPCNKREPGSGCGARDGVHRDHAVLGHSEHCIATHPSDMAVALAALDAQVELYGTGGTRRLAVADLHRLPGEHPERDTWIRPGELITGVLLPAATAGVPSAYRKARDRASYAFALASVAVVLKVTDGVVDQAGVAFGGLAHRPWRARHTELALLGAPATPAAFEGAVALELAHAEPLRDNAYKVPLARNLALDVLHRLAPAPATA
>CP033073.1|AYN38272.1|957165_959235_-|xanthine-dehydrogenase-family-protein-molybdopterin-binding-subunit
MGAPAERREGRQKVTGAARYAAEYAVPGRAHAWPVPAAVASGRVTGVDTSAALALPGVLAVLTPGDAPRLAEAEDATLAVLQDPAVPHRGWCVALVVAETPETARAAARAVRVHYDSRPHDVNLSEGHRDAYAPEEAGGQPGTLEHGDPEAAFAAADIRVDVAYRVPPLHNHPMEPHASTAHWDGDRLTVYTSSQGGTAVRSVLAKLFELPEEQITVVAEHVGGGFGSKGTPRPDVVLAALAARHTGRPVTLACHRRHLPTVTGHRAPTRQRIRLGTDADGRLTALLHEVTTYTSRVKEFVEYAAVVSRTMYATPALRSAHRVVPLDVPSPSWMRAPGEAPGMYALESALDELADALGMDPVELRVRNEPDREPGSGKPFSSRNLVRCLREGARRFNWADRDPRPGVRREGPLLLGTGVAAATYPVMVSPSSAAVEALPDGTFTVRVNAADIGTGARTVLAQIAADALGVPLDRVRCEVGHSELPPAPLAGGSSGTASWGWAVHEACTRLAAHPGPLPPDGLTVRADTTGRADADSPYARHAFGAHFAEVAVDTVTGEVRVRRMLGVFAAGRILNARTARSQFTGAMVMGLGMALTEGSTLDPAFGDFPETDLAGYHVPAHADVPAIEADWIDEDDPHLNPMGSKGIGEIGIVGTAAALGNAVHHATGIRFRELPLTPDRVLTGLLSEG
>CP033073.1|AYN43482.1|955314_956064_+|class-I-SAM-dependent-methyltransferase
MDAERYDRARPPYPDALVDRIVTASPGRDVLDVGAGTGIEARQFQAAGCTVLGIEPDERMAAFARRSRVEVEVARFEDWQPAGRQFDAVIAGTAWHWVDPVAGAAKAAQVLRPGGRLAPFHHVPQLPEEVIDALAEAHRQVAPDSPLDLGLLKGSALDASRPLFARITDGIRQTGRFSEPEQWRFAWERTYTREEWLDQLPTFGALTRLPADELAEVLDSVGAVIDTLGGHVTVPYITVAVTSTRSGTA
>CP033073.1|AYN38271.1|954571_955171_-|TetR/AcrR-family-transcriptional-regulator
MPSGVHIHNVRGQLFEAAERVLLRDGPDALTSRAVTEEANCAKGVLHRHFTDFDAFLTELVLDRIRGIEDRATVLSAAAGTGSVVDNLTEALQDLFGPVTVAIVALITFRDGLRARLRQAGLTGIPLAMQATSMIAAYLAAERELGRLADDADIDTLAPTLVGAAHLLFADRASAPPQTAAIRKTVTAVIASGLRPPRV
>CP033073.1|AYN38270.1|953352_954153_-|DNA-binding-response-regulator
MHVSDVPLRVLAVDDEQPALGELLYLLGQDPRVGTVVPAPAATEALRRLGRAMEEGPDGADAFDVVFLDVSMPGLNGLELARLLGGFATPPLIVFVTAHEDFAVRAFDLKAVDYLLKPLRRERFAEAVRRVAELVRAGQGPRPAALPTPTAALGDQIPVELGGVTRFVPVADITYAEAQGDYARLHTRDGSHLVRVPLSTLEEQWRARGFVRIHRSRLVALGRIEELRLDGGNLSVRIGDRILAVSRRNARELRDLLAVRATARPR
>CP033073.1|AYN38269.1|952732_953113_-|hypothetical-protein
MGTESVPRREVVTGRPHTPGGGRTVPPPVPAPAPGPAHPDADAVRALMRRQLRAALTATALLAAPLGLLPVLLRVLPLADSEPRVPPALWLLLGVAPYPALLGIGAWYVRRAERNETGTPAPAERP
>CP033073.1|AYN38268.1|950982_952701_-|cation-acetate-symporter
MNRTYGIAGVTAVVLATVLVGALGLRVSRTTSDFYVASRTVAPRLNACAVSGEYLSAASFLGVAGLVLAQGVDMLWFPIGYTAGFLLLLAFVAAPLRRSGAYTLPDFAEARLESRAVRRIAGGLVVGIGWLYLLPQLRGAGLTLRLLTGVPGWVGGLIVAAVVTVAVAAGGMRSITFVQAFQYWLKLTALLVPVAFLLLAWRADHAPAPSWEDRPVFHRPTEVRLDRPVTLTAHAPVRVTVSGSVDGRTVHGGSVTLAEGGHRIGADTVLRFPAGARVPLPDRASGRTAQSSWARPLSADREQHSLYATYGLILATFLGTMGLPHVVVRFYTNPDGRAARRTTVIVLGLLGAFYLLVPLYGMLGRLYAPDLLLTGDTDAAVLVLPQRLIGGVAGDLLGALVAGGACAAFLSTASGLTLSVAGVLAQDVLPTRGVRHFRFAALPAIAVPTAAGAVVSDLPVADAVGLAFAVSASSFCPLLVLGIWWRGLTPPGAIAGLLLGGGSALTAVTVTIAGGARSGWLHTLLAWPAVWSVPVGFAAMVLTSLATRDRVPPGTTATMARLHLPEPTPVHP
>CP033073.1|AYN38277.1|964339_965572_-|FAD-binding-protein
MTATRRVDVLVVGAGPAGLAAAARLAVAGAGRVEVLEREASPGGVPRHCAHGGFGTWTRPLTGPRYARLLTEAAERTGATVRTRTTALDWATEGPVLHAVGPGGPEIIEARAVVLATGARERPRPARLVPGTRPAGVYTTGELQQSVHLFGQRIGSRAVVVGAEDVSYAAVGTLRTAGTEVVALVTEHPRARTGRARAEAARLLHGIPLLTGTTVAELLGHGRLSGVRVRHRDGRTAVLPCDTVVFTGDFVPDHELARRGGLTLDPGTRGPAVGGSLHTSRPGVLAAGNVLHAVEPAGTAAREGARAAGAVLDLLAGAPWPDPGVPVTVEAPLRWIAPNRVTPGARPTRHVLRTGTALTRPVLLVHQDGRLLHRERRGPGTVPPHRPLALTGHWHDRVDPEGGEVRVSTA
>CP033073.1|AYN38278.1|965568_966984_-|FAD/NAD(P)-binding-oxidoreductase
MTVTADGPLPSTAYDVAIVGAGVVGCAIARELARHPRLSVALVEAQDDVGQGTSKANTAILHTGFDATPGTLEARLVREGYERLGAYAAETDIPVERVGALLVAWDEEQLAALPRLAAKAERNACPGTALLGPGELYAREPRLGPGALGALHVPGESVICPWTTTLAYATQAVRAGVDLHLNTAVRDARWADGHRLTTTRGTLRARHLVNAAGLHADTLDRRLGHQDFTVTPRRGQLLVFDKLARPLVRHILLPVPTALGKGVLVTPTVHGNVLLGPTAENLPDRQATGSTADGLAGLRDQGRRILPALLDEEVTAVYAGLRAATEHEDYRITAHPGQAYVTVGGIRSTGLTASLAIAAHVTGLLTDAGLDPGPVREPDAVVMPQLGEAFPRPYQRADLIAEDPEYGILVCHCERVSRGEIRDALAGPVPPRSLEGLRRRTRARAGRCQGFYCGAAVRELFERGPDGRNGP
>CP033073.1|AYN38279.1|966980_968411_-|carbohydrate-kinase
MTGPVLAVDQGTSGTKALVVCPERGVLGTGFAEVRPRYLPGGLVEVDPAGLYDSVVDAGRRALAEAGEDVVALGLANQGETVLAWDPATGRPLTDALVWQDRRAETVCAGLAAHADELRRLTGLPLDPYFAAPKMAWIRRHLTREGVVTTSDAWLVHRLTGAFVTDAATAGRTQLLDLDSATWSPRALDLYGLAGERLPEVTDAAQPVGTTRAFGPEIPLTGLAVDQQAALLAQRVTGPGAAKCTYGTGAFLLAHTGDRPRRGASGLVNCVAWRLAGHTSYCLDGQVYTAASAVRWLTDLGVLSGAADLDPVGGTVPDSGGVTFVPALAGLAAPWWRGDLRGSLTGLALDTTPGHLVRALCEGIAAQVAELAEAAATDLGTPLDTLRVDGGLTRSALLMQTQADLLQRPVEVSALPDATALGAAALARLGVDPALSVEDALPDWKPATVYEPRIPADRAAEHRARFRTAVAALLGP
>CP033073.1|AYN38280.1|968643_969642_+|hypothetical-protein
MARGRRLMARDGVRPSYDPAGPDQALRAALQDLRTGRWMAMRALLADTTQWWRWTQRTQILAAAAAGTDVVRAWLAEEPGNVHAAVMHARVLVERALRARRERHRRTHELWIEAWDAAQSATATAPRDPVPWVCLLALAQLDPEQRWEEHRAAAPEPMLPPGPWGLLAEAGRRDPDNREAHHRMLQFLYVRGGSGRLAEAAGYAQWAAGQAPPGAAAHLLPLYVRVERYRRDSGHDAALDLHWVGDEAAREARRGLHSWFENTQRAERSLSDLNHLAHALWGSLQFSDASRVFEAIGPYFTPPPWMYRTPDRERAVEIFVQARDRCRAAADG
>CP033073.1|AYN38281.1|969795_971334_+|amino-acid-permease
MSPTPDPSSAPATGLPQQDEEQRLRELGYRPVLARRMGGFGNFAISFSVISILSGCMTLYGFGLNTGGPAVMLWGWAGVGVFVLCVGLALAEVTSAYPTSGALYYMADRLGGRRWGWYTGWLNLLGLLGAIAGIDYGAALFTGAFANLQWGFEPTPGRTMLIFCAILLLHAVLNLFGVRLVSVLNSVSVWWHLAGVALIVGALAIFPDHHRSPSFVFTKFVNETGWHNPLYVAAIGLLLAQYTFSGYDASAHLSEETSHASVAASRGIVRAIWVSWLAGFVLLAGLSFAIQDYDATRTTDTGVPPARILLDGLGTGGASALLLVVIVAQLFCGNAEVAAASRMVFAFSRDGALPGSHLWRKVSDRTQTPVAAVWLSVTVAFVLALPSLYSATAYNAVTAINVIGITPAYAIPVYLRLRAGDRFQRGPWHLGRWSRPVGWVAVVWVACVTVLFCLPQSSPVNVDTMNYASVALAVVLVLASVWWYVARRSYGTPTTAAYGSDRDQADLAEGIV
>CP033073.1|AYN38282.1|971522_972614_+|mechanosensitive-ion-channel-family-protein
MNRTPTLDDLVLAGIALGAGLLLAFLSRTLLHWLGGHAKRTRWSGDDVIVDALRSVVPWAAIAGGAAAAAAVLPLTGVVQHHADQTLQVWLIAVVTFSAARVIAGLVRTVTQSRSGVAGSATIFVNITRVLVLAIGFLIVLQTLGISIAPLLTALGVGGLAVALALQDTLANLFAGVHILASRTVQPGDYIRLSSGEEGYVVDINWRQTTVRQLSNNLVVIPNGQLAKANMTNYTRPEQELTVLVQVGVGYDSDLEHVERVTAEVVAEVMTDVTGAVPDHEPAIRFHTFGDSRIGFTVILGVGEFSDQYRVKHEFIKRLHRRYREEGIRIPAPTRTVALQQGSVVIPQQRSGEETTPESARTE
>CP033073.1|AYN43483.1|972657_974037_-|MFS-transporter
MLAALALAQFICSFAGSNMNVMINDISEDLDTTVQGVQVAITVFLLVMAALMIPGGKLTDRYGRKRCFVVGLVVYGVGALLSAASPGLGVLILGNSVLEGVGTALLIPPVYILTTLLYPDLTSRARAFGIIMALGGIGAAAGPLIGGLITTGISWRAAFVFQALVIAVIVWLSRRIEDPLPPDPGRSFDTSGAVLSAAGLILVVMGILAADNNIWLMIGLIVLGVLVLGWFLRSSRAKERAGREPLLSLGLFRNRTSNLGLITQNVQWLLLMGTSFTVAAYLQVVRGYDAIQTGVIFTAATLGLLVTSLSAAALARRRSQRALITSGFVVAVAGVGVLVGLAASFSTAWAFVPGLLLVGLGLGLMLTPSVNVVQSSFPEERQGEISGLSRSVSNLGSSFGTAIAGTILVAGLTKGAYAVAMITLAVIGLGGLAAGALLPRTPAPSRAGDTPATAPGTRT
>CP033073.1|AYN38283.1|974077_975988_-|glycoside-hydrolase-family-15-protein
MDRYPPIAEHGLVGDLQTAALVSSGGTVDWWCTPRFDSPSVFASLLDSERGGHCRLAVDGLDGHVSVRQLYLSDTAILITRFMGPGGVGEVADFMPPVDSPTPTDRHRLIRIARVVRGSLPFTFMCRPRFDYGRVPHTLGVTDDHQAVLRGPGTDLHVQSTAGAPLRADGADVTARFTLGAGQAAAFVLTSAAAGAPAPAAPALPGIAQEVEECRLYWLSWLRSCTYHGRWQDMVNRSAITLKLLTYAPTGAPIAAATMGLPEQVGGERNWDYRYTWVRDGSLSVGALTDLGFEAEAYAFRRWLRDRVEAGGTASGDPLQIMYRVDGEPHLGEEILDHLEGYQGSRPVRAGNAAVDQLQLDIYGEASDALMVGGDVGAVRGWKALSGVLDWLADNWDRPDEGIWETRGGRQDFTYSRLMTWVAFDRGIRAATQFSRPADTARWTAVRDTVFRQIIERGWHDKRQAFVQHFDTDVLDASLLLMPRVGFLSPRDPDWISTLDAMDGELVSDSLVYRYDPAASPDGLRGSEGTFNLCSFFYVEALARSGRLHQARYAFDKMLTYANHVGLFAEEIGPSGEQLGNFPQAFTHLALVTAAMALDEELGQATTGAGTDTARHSAIQGLTARDGATGKESAGD
>CP033073.1|AYN38284.1|976009_976441_-|hypothetical-protein
MTATHPTGAHTRSARQAWAGGLTSFAGVMLSIAGLLAVFRGIMAIAHDDVFVSTPNYVFKFNLTSWGWIHLILGVIAVIVGFGLLGRATWARVSGIVIAGLVIIANFLSLPYYPLWSIVLIALSGFIIWALCVVEDDDSAVSR
>CP033073.1|AYN38285.1|976474_976945_-|SHOCT-domain-containing-protein
MSAQTYLAYDYPLLSAFWTMLVFFLWILWFVLLFRIIVDIFRDDGLNGWAKAGWTLFVCVLPFLGVFVYLIARGRGMGEREVADARARQEAVDSYVRQTAQSGMPQPSHADELTKLSEMRSRGDITDDEFRRAKELVLSGAGPARGPDSVSTVSGR

Crispr_ID: CP033073_4

• CRISPR_ID: CP033073_4
• CRISPR_location: 1827531-1827803
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of CP033073_4

Consensus_repeat	Method
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	PILER-CR
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	CRISPRCasFinder
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	CRT

spacers of CP033073_4

>4.1|1827560|32|CP033073|PILER-CR,CRISPRCasFinder,CRT
CCGGCGCAGTGGCCGCAGATACGGGCCGATGG
>4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT
TGTGGTCGGCCCAGTATCCGGTGCACGAGGTG
>4.3|1827682|32|CP033073|PILER-CR,CRISPRCasFinder,CRT
CCGAGGTGACGGATGGCATCGCCGGCTGAGCT
>4.4|1827743|32|CP033073|CRT
GTCTCACTCATGAGAGTGAGGTCCATGTGTGA

CRISPR arrays and Neighbor proteins around CP033073_4

CRISPR arrays

The CRISPR arrays of CP033073_4

>merge|CP033073|4|1827531-1827803|PILER-CR,CRISPRCasFinder,CRT
GTGGTCCCCGCGCACGCGGGGGTGGTCCCCCGGCGCAGTGGCCGCAGATACGGGCCGATGGGTGGTCCCCGCGCACGCGGGGGTGGTCCCTGTGGTCGGCCCAGTATCCGGTGCACGAGGTGGTGGTCCCCGCGCACGCGGGGGTGGTCCCCCGAGGTGACGGATGGCATCGCCGGCTGAGCTGTGGTCCCCGCGCACGCGGGGGTGGTCCCGTCTCACTCATGAGAGTGAGGTCCATGTGTGAGTGGTCCCCACACACCTGCTCACACCGCG

>CP033073|4|1|1827531-1827742|PILER-CR
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	CCGGCGCAGTGGCCGCAGATACGGGCCGATGG
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	TGTGGTCGGCCCAGTATCCGGTGCACGAGGTG
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	CCGAGGTGACGGATGGCATCGCCGGCTGAGCT
GTGGTCCCCGCGCACGCGGGGGTGGTCCC

>CP033073|4|4|1827531-1827742|CRISPRCasFinder
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	CCGGCGCAGTGGCCGCAGATACGGGCCGATGG
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	TGTGGTCGGCCCAGTATCCGGTGCACGAGGTG
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	CCGAGGTGACGGATGGCATCGCCGGCTGAGCT
GTGGTCCCCGCGCACGCGGGGGTGGTCCC

>CP033073|4|1|1827531-1827803|CRT
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	CCGGCGCAGTGGCCGCAGATACGGGCCGATGG
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	TGTGGTCGGCCCAGTATCCGGTGCACGAGGTG
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	CCGAGGTGACGGATGGCATCGCCGGCTGAGCT
GTGGTCCCCGCGCACGCGGGGGTGGTCCC	GTCTCACTCATGAGAGTGAGGTCCATGTGTGA
GTGGTCCCCACACACCTGCTCACACCGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN38870.1|1818767_1819664_-|DUF91-domain-containing-protein	unknown	unknown	gnl|CDD|226114
CP033073.1|AYN38869.1|1815845_1817936_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38872.1|1821682_1822228_-|alpha-glucosidase	unknown	unknown	gnl|CDD|379501
CP033073.1|AYN43550.1|1826959_1827220_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38881.1|1836798_1837803_+|inositol-monophosphatase	unknown	unknown	gnl|CDD|223559
CP033073.1|AYN38882.1|1837807_1838740_-|NADP-dependent-oxidoreductase	unknown	unknown	gnl|CDD|176191
CP033073.1|AYN38873.1|1822352_1822946_-|alpha-glucosidase	unknown	unknown	gnl|CDD|379501
CP033073.1|AYN43549.1|1823500_1824682_+|acyltransferase	unknown	unknown	gnl|CDD|224748
CP033073.1|AYN43551.1|1838973_1839525_-|HD-domain-containing-protein	unknown	unknown	gnl|CDD|188314
CP033073.1|AYN38874.1|1825889_1826945_+|protein-kinase-family-protein	unknown	unknown	gnl|CDD|271005
CP033073.1|AYN38880.1|1834866_1835616_+|HAD-family-hydrolase	unknown	unknown	gnl|CDD|223710
CP033073.1|AYN43547.1|1814265_1815858_+|translation-initiation-factor-2	unknown	unknown	gnl|CDD|224799
CP033073.1|AYN38877.1|1829757_1830300_-|DUF1360-domain-containing-protein	unknown	unknown	gnl|CDD|369207
CP033073.1|AYN38878.1|1831381_1832596_-|serine/threonine-protein-phosphatase	unknown	unknown	gnl|CDD|369272
CP033073.1|AYN38875.1|1828228_1828963_+|DUF2071-domain-containing-protein	unknown	unknown	gnl|CDD|378271
CP033073.1|AYN43552.1|1840336_1841311_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38879.1|1833383_1834910_+|mannitol-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|223324
CP033073.1|AYN43548.1|1821252_1821489_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38876.1|1829002_1829548_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN38871.1|1820420_1821182_+|IS5/IS1182-family-transposase	unknown	unknown	gnl|CDD|372649

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN38870.1|1818767_1819664_-|DUF91-domain-containing-protein	gnl|CDD|226114	COG3586, COG3586, Uncharacterized conserved protein [Function unknown].	3.10202e-15
CP033073.1|AYN38872.1|1821682_1822228_-|alpha-glucosidase	gnl|CDD|379501	pfam14200, RicinB_lectin_2, Ricin-type beta-trefoil lectin domain-like.	4.58313e-12
CP033073.1|AYN38881.1|1836798_1837803_+|inositol-monophosphatase	gnl|CDD|223559	COG0483, SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism].	1.72783e-62
CP033073.1|AYN38882.1|1837807_1838740_-|NADP-dependent-oxidoreductase	gnl|CDD|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	9.20781e-98
CP033073.1|AYN38873.1|1822352_1822946_-|alpha-glucosidase	gnl|CDD|379501	pfam14200, RicinB_lectin_2, Ricin-type beta-trefoil lectin domain-like.	5.68911e-14
CP033073.1|AYN38875.1|1828228_1828963_+|DUF2071-domain-containing-protein	gnl|CDD|378271	pfam09844, DUF2071, Uncharacterized conserved protein (COG2071). This conserved protein (similar to YgjF), found in various prokaryotes, has no known function.	1.51071e-65
CP033073.1|AYN43549.1|1823500_1824682_+|acyltransferase	gnl|CDD|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	6.70844e-32
CP033073.1|AYN43551.1|1838973_1839525_-|HD-domain-containing-protein	gnl|CDD|188314	TIGR03401, Uncharacterized_protein_YFL061W/YNL335W, HD domain protein, cyanamide hydratase family. Members of this protein family are known, so far, in the Ascomycota, a branch of the Fungi, and contain an HD domain (pfam01966), found typically in various metal-dependent phosphohydrolases. The only characterized member of this family, from the soil fungus Myrothecium verrucaria, is cyanamide hydratase (EC 4.2.1.69), a zinc-containing homohexamer that adds water to the fertilizer cyanamide (NCNH2), a nitrile compound, to produce urea (NH2-CO-NH2). Homologs are likely to be nitrile hydratases.	1.47729e-07
CP033073.1|AYN38874.1|1825889_1826945_+|protein-kinase-family-protein	gnl|CDD|271005	cd14103, STKc_MLCK, Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module. MLCK2, MLCK3, and MLCK4 share a simpler domain architecture of a single kinase domain near the C-terminus and the absence of Ig-like or FN3 domains. The MLCK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.	0.000182539
CP033073.1|AYN38880.1|1834866_1835616_+|HAD-family-hydrolase	gnl|CDD|223710	COG0637, COG0637, Predicted phosphatase/phosphohexomutase [General function prediction only].	3.4991e-20
CP033073.1|AYN43547.1|1814265_1815858_+|translation-initiation-factor-2	gnl|CDD|224799	COG1887, TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane].	4.58115e-05
CP033073.1|AYN38878.1|1831381_1832596_-|serine/threonine-protein-phosphatase	gnl|CDD|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	5.95005e-45
CP033073.1|AYN38879.1|1833383_1834910_+|mannitol-dehydrogenase-family-protein	gnl|CDD|223324	COG0246, MtlD, Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism].	5.60374e-148
CP033073.1|AYN38877.1|1829757_1830300_-|DUF1360-domain-containing-protein	gnl|CDD|369207	pfam07098, DUF1360, Protein of unknown function (DUF1360). This family consists of several bacterial proteins of around 115 residues in length. Members of this family are found in Bacillus species and Streptomyces coelicolor, the function of the family is unknown.	1.29273e-42
CP033073.1|AYN38871.1|1820420_1821182_+|IS5/IS1182-family-transposase	gnl|CDD|372649	pfam13613, HTH_Tnp_4, Helix-turn-helix of DDE superfamily endonuclease. This domain is the probable DNA-binding region of transposase enzymes, necessary for efficient DNA transposition. Most of the members derive from the IS superfamily IS5 and rather fewer from IS4.	9.42077e-13

Protein sequences

>CP033073.1|AYN43550.1|1826959_1827220_-|hypothetical-protein
MGGRAVMLIPHRTSDVEENVLPPDYQRILAAVRQAAGPVMARQAGEMLGVDVNIRSKLEPLRGKLVRLVDRGWLRKLPDGRFTTRL
>CP033073.1|AYN38874.1|1825889_1826945_+|protein-kinase-family-protein
MSRGARLTAHGAVSTSLALRSDRSLREFVDAGAPLGSGIGGRTVLLEVEGTRVFVKQVRLTDLERRPEHAHSTANLFGLPAFCHYGIGTIGGPGFGAWRELAAHTMTTNWVVAGDYKGFPLMYHWRVIPDSGQPLPEELADVDRAVAYWGGGSAVRRRIEALQHSTASLVLFLEYIPQNLHDWLSVQIGSGDVVAERACAMVDDELKASIAFMNARGLLHFDAPFENILTDGRQLFFTDYGLAISSRFDLTRAETDFFDQHRTYDQYYAVTHLVNWLAVALYGYTPEERKTFVNACAQGAPPEGVPASVAALLVRYAPVAAVMGDFYREFQQVSRAAPHPLATICRMGRSA
>CP033073.1|AYN43549.1|1823500_1824682_+|acyltransferase
MEQQARASDTQGQRQLAGLDGLRGLAALYVVLFHCWLYSFPGYPDSSAPPWLEGLMFGRLAVVFFLVLSGFSLAISPARHSWRSGGVGRFLRRRAWRILPPYWAALAMSLIVSWLVVPASHFGPPTGMSILVYGLVAQDSFTAPTPNGAFWSIGVEAELYLLFPMFLFVRRRVGAAALVACVTIPVIARGLAAANATPVEGDNWLAPHLAPVFVAGLVGAAVVTASDRVRRLPWGWFAALAAVPVLALCLAQGSIWTVKHYFWIDLAIAPAMSMTLAAVATGRPAILVRFLTARPIRNLGSFSYSIYLIHLPIVMTVIRRVAPLFLSPGLPVFWFTLIVALPVSVLGAWLFSKIFEMPFKRARSLRSLIEALPRGRRRPGVEVQPSSAQHGPA
>CP033073.1|AYN38873.1|1822352_1822946_-|alpha-glucosidase
MYTTQLRYAVTAVLASALITVASPALAHAQQSQQNSDWGQPIPSSQVLSGNLLSIKASGIGIGNLKSKKFLQANSTANGAKVVQQPGNSVNPLQNWAAVNDSPYTSFENVAAGRNLGIDGASTASGAAAIIANGAGDANQDWKLVPVTGYPDGYFAMKNRKSGLCLGISGASTANGAQAAQFACDGSANQGWGLFNP
>CP033073.1|AYN38872.1|1821682_1822228_-|alpha-glucosidase
MRTTRSKAAVVATAAGALLALASPAHAHAKAQQASDPKPAKLAAGASRIKNLKSGKYLQAASTAHGAKVTQQTYDDGTTLQSWETYIFGDYYTFENSGARKNLGIDGASTASGATAIIANGSSDLNQDWIVDWTLYDGDHFALKNRKSGLCLGISGASTATGAQAAQFRCDGSANQGWSKE
>CP033073.1|AYN43548.1|1821252_1821489_+|hypothetical-protein
MPSVEPFSEVHVSRPGLIVVDVAANDEETALAFQQAVAARWATAVADRITREPGQPGVRLRCYVDLRQALDAQTPETQ
>CP033073.1|AYN38871.1|1820420_1821182_+|IS5/IS1182-family-transposase
MITASEPSWIAPFTGLSPRQFGKLVTALRREGADPVRKGRPWSLPLEDRVLLVAAYWRTNLTLRQLAPLFGVSKSAADRIIDHLGPALALQQRKRFRKDTMLIVDGTLVPTRDHQVAEQSKNYRYSTNHQVVIDADTRLVVAVGRPLPGNRNDCKAWELSGTKDAVGHTTVIADGGYRGTGLVIPHRRQPGQADLPEWKEEHNASHRKVRARVEHAFARMKTWKILRDCRLKGDGVHHAMLGIARLYNLTLAG
>CP033073.1|AYN38870.1|1818767_1819664_-|DUF91-domain-containing-protein
MSGLKLFRTDTTDSGMIEVMPRLAEIEADVQGLVEEHMETLLGVRFLASEYSTGSLHGGRIDSLGLDENGSPVIVECKRGTDAGVINQGLFYLAWLMDHRAEFENLVRDRLGVTAASHSLWSGPRLICIAGDFSRYDVHAVREHRRSIDLVRYRLFGSDLLGLETVASVSGGMQVARRAWRQSVAQAAADVQGAAMVELAGAVDEVLLGLGDGVNCVERKTYRAYQRLRNFPCLCPPQRSKLLVYLKFNPKDVDLVPGFTRDVSGLGHHGTGDLEVELRTPRDVERAQNLFRASYAAV
>CP033073.1|AYN38869.1|1815845_1817936_-|hypothetical-protein
MSEETYNSLDGRADVVVQAGRIGEVHQHLHGAGVSPQPTPIQLPPALAYFEDRQAEQERIAQAAEGHRGHAGPLVVALTGIGGIGKTALGFHVARQLSDRYPDGVLYVDLDDLRRDGVVEVADAVGELLTGLGVSPDWLERSFAGRSKQYWTRSRDKRLIVVIDNARYGAEAVPLLPASAQSLAIVTSQGLLYDLDGVAAVEVPVNPLAVDDAVRLLRHIVDDPRLEAEPDAVAELARSCGGLPAALQVAGQWVRKYRRRSLSRLVAELTAELHERGLPMIEAVWDAACSGLGPEAGRLYCLLPQYPAPVITCPAAAALLGGGLLPAEDALEELESAGLLENRPEGYRMHELLRGHAERRARQTDPEGVGRAEARRRLIRWYRRQAGRADLLAAGPRMTFADPVAVVEDVPDVDFAGKAQALRWLESQRLALYGCVRLAFETELYEDAWALCEPLWTHFLDHPHYADVTDAFRTGVAAADRLECLPAMVRMRCQLARPLWEQERYDEAAEQLRHALGASEALGESAQERKLKASVREFQGLLKSAQRDWTGATADFEAARQVHAAIENAYGVLLQTYLLGRTALSQGEPERAVALLSTAHSMAREQDRERMTSRAGFELGRALRRAGRAAEAGGLVRAALVNARERGSTFDEARVLEELAALADELGETAEAEEYRTAAQLLAARSGALPDGGQSS
>CP033073.1|AYN43547.1|1814265_1815858_+|translation-initiation-factor-2
MHRLLDVLPVFEGDERVLVRFTLVPGSVFDADAFAALERSGARTVSWEEARASEHDLILTASPKGALRVLSGPGVLLPHGAGFNKTVSGDGSPRIPSGLDPHYLLVDGEPWAALHALAHDEQLTRLAEYCPSAAARAAVVGDPTLDRLLGSLAHRGNYRSTLGTGERRLIVLTSTWGPESLLARRPELPGELISQLPHDEYQLALVLHPNEYSRTSAFDLSRHLAPALSGGLALARPYEEWAALLVAADAVVTDHGSTALYAAALGRPVIGAYDGGSELIPGSPMAKMLAQVPRLAKAADLVHVLPAAEAHDTRGFAEAAFALPGQALQRLQSELYSLLRLRPRTVPVAPHPLPHPAAPQRPLALAVRAEVSGCRISIERFPSFTSEAVHHLAAEHPEAGQRHVQSASVLWRRARPASPAPHTSTWTAAGWTARVLEDAPGCRTAAAILSPERCLVRHRSAGPLSIRIEPCTTTDRVLRTDPGAVVSAVHAWLGATPQWALPVSLVCEIGPLTVRVGLAPADEADLTYEL
>CP033073.1|AYN38875.1|1828228_1828963_+|DUF2071-domain-containing-protein
MVAHGAEQRVRLPALRAGWLTQTFVHWPFRPEAVQALLPEELVVDTYDGAAWVGLTPFVMADVRLPGVPAALPGLPTFAETNLRTYVRYRDGRDGLWFLSIEVAFLPMLAARAIGAPYNPGTLSVSTDGDTVSYSGTRGNGDASYRLIVRRGDPIEPTERDVWLTSRWRAYTRRLGTLWETPVEHEPWPLAHATLDLLEETLTTAAGLEEAPLGEPVVHFSKGVRQVRLGLSTPRIPWRVRQPS
>CP033073.1|AYN38876.1|1829002_1829548_-|hypothetical-protein
MLKRALWQGLLAGTAGGVVMTLGEKIEQAVTGRPDSHVPARVLQRLSGLPERPGNQPLPVNWAMHYGQAALLGVLRSIMAQSGLRGPIASAKFTVVRLTSDQILENATGVGAPPTTWPRQELVVDLLHKTVYAFTTGAVADALAARSGPGPGQRHAAVRPGGHARFGPLPRRDAYGAGGRR
>CP033073.1|AYN38877.1|1829757_1830300_-|DUF1360-domain-containing-protein
MDTVADNRLARRVHGLLQRTGRGYSAGHDRPLGGYLAAMAGFAAYTTAWATAVRLRGRPLPDRPEPWDVVLTSVATFRLSRLLTKASVTSPLRAPFTKYVAPQGPAELHEEAKPEPGKHTVGELATCPFCMSVWVASTLTAGQLLWPRATRTAMGALTALAGADTLQLAYSALIEKTTGD
>CP033073.1|AYN38878.1|1831381_1832596_-|serine/threonine-protein-phosphatase
MTESSASLVRLMQASHTATLEQLPEMIAEHAAAAGMHDVAIFVVDVRETVLRRLTGQGPAAGAGGQEFTVAGSLPGQAFQRVELLPERDGAGDPPGGRRWWVAITDGVERLGVLRADTHTDGEPIRRALRDLASMTALLLLSKRSFSDSYARLVRTEPMNVAAEMQWNLTPPPAYAGNDATVGAVMEPAYQVGGDTFDYAVAGSTLHLSVFDAMGHDTTAGITANVAVSACRNARRQGASLAETSEQVEQTLIEQFSTSRYVTGILADLDMETGRLTWVNRGHHLPILIRGNRWTTELACRPAGPMGAGLGLPVTTATEQLEPGDRLLLYTDGIVEARDARGREFGRDRFVDFILRHHSGRHTLHETLRRLMAAVVEHHDGKLNDDATVLLTEWRGGHQQQLNP
>CP033073.1|AYN38879.1|1833383_1834910_+|mannitol-dehydrogenase-family-protein
MPESPSPVPALNNRSLDASPGGQLETPGYDRTRIEPAVVHFGVGGFHRAHQEVYFDQLAELGFTRWGVIGVGMRRPEMGQVLDAQDNLFTVVQRDGDDCTAKIIGSMVEYLLLTEERARVEARLADPRTRLVTLTITADGYTLPDDPEMARDSVFGLIIDALDRRRHAHHAPFTVLSCDNLPDSAAATREAVMTLAGRRDPALARWIEERVSFPGSMVDRITPATTPGDRDEIQEDFQVGDRWPVITEPFTQWVIEDDFCNDRPPLDRVGALFVDDVAPYKLIKSRLLNGVHCALGYVGYLAGHRSTDQAMADPVVAGFVQRLMREEIAPLLPADIPGMDLGTYCDTVLERLRNPSIGDQLARLCRRGSTKMPDYLLPSLHCAHAQDRPRTRLAFAVAAWMRFLRGVDLDGAPIDVQDARAEELREAALQGGDDPAPLLAVTDIFGDLADDADSVAVIRNSLAGAFGSGESLRTALASPARPAERPVTPRSQEPHEHPRPDQRHDTAA
>CP033073.1|AYN38880.1|1834866_1835616_+|HAD-family-hydrolase
MSIPDLTSVTTLLLDADGTLFPSEEPAFVASATVTRDFAHHFGLTGDFSPEHLRLTTTGSNFRTTARNLAERQGVHLDAAELEAWVEREKTEVTAYLGQVLTPRPDVVAAVSALGRRYRLAVVSSSALTRLDACFTASGLGGLLPADRRFSAEDSLPVPTSKPDPAVYRFALTRLGVAPHQALALEDSATGAASAVAAGIATAGLVQFVPAGERPGRIEQLHDAGAAWVRPSWGELASDLVGDAVRVAT
>CP033073.1|AYN38881.1|1836798_1837803_+|inositol-monophosphatase
MSSSAAVPSTRSGCCPDVCVPWRRPRAPLSPGRWSGGPPGTPYGRTPVNLDDLLSLARDAARAGSRTAVSWRGHAHQLLIQEKAGPDDLVSQADRDTEHAVRAVLAEHRPHDTVLGEEEGTTTGRSRVRWIIDPIDGTTNYLYGRPDWAVSVAATDTDGDRLLAGVVIEPALGLLTEARAGTRTLANGTPVTPLRQHDLDRVLVELNFGRPGQRPLAGPAVSALLPRVRDLRRGGSAAAALAQVATGRADALWAPGLQPWDCAAGVLLVQQAGGTVGDLTGPAPGTWPRSGDVLAAPPALWKSLRTLLTPVYPAAEAMRTGRPDSDDANMAGRA
>CP033073.1|AYN38882.1|1837807_1838740_-|NADP-dependent-oxidoreductase
MQAVTVRDREAGVTGLALEDLPHPHAAENDVIVRVHAAGFTRGELGWPATWADRAGRDRTPSVPGHEVSGVVTELGYGTTGLTVGQRVFGPTDWARDGSLAEYVAVEARNLAPLPADVDHTVAAALPISGLTAWQGLFDHARLTSGQTVLIHGAAGAVGSMAVQLAHEAGAHVVGTGRSADRDTVLDLGAHAFLDLDAGPLADAGQADVVFDVIGGDILDRSAALVRPGGTLVTIAHPPTVRPDDGRALFFVVEPDRARLADLARRLRDGRLRVRVGAVRPLAEAVAAFTPRQRVPGRTIIRVAEPPAGR
>CP033073.1|AYN43551.1|1838973_1839525_-|HD-domain-containing-protein
MIFHHSRRVFLFGSLHARELDLRPDPELLYISAMFHDAGLSIPFSDTRQRFELDGADHARKFLLDRGFPESAAEVVWRAIALHTTPGIPGRMDPEVAATNYGVLTDAVGWGLDRLQGGQLDEIVAAHPRGDFKKEFLQAFVDGLEDRPDTTYGTVNADVLEHFVPGFRRTSMVERVMDAPWPR
>CP033073.1|AYN43552.1|1840336_1841311_-|hypothetical-protein
MRANYASLKAELVKYLSPVVVVENNAVGGRFTLINKGVQIETVNPVPEYFELAKSIAHVPLGIYSVLAGYLADQVPNIPGAARIDPHDLDMVAFRTPGDKGWITPLNSYRTTLGSALTMLPTANLPADLDASCTRILTEAVKFIDTIVKAGSFDMVAFNRFAATVYPSIRVNMTFAATAQINGIEGLMKRWRTLIGEQAWSDLYVTVLSIWTTSELNQASIIIRRTMNQAKAATHLIDLPTVQTPSDPIAVALDNLARIVQDNVAAEMVFNADLKVADALKGKEDLLSDEILQQIGGTAPAARTAAFAAPAAGTCPITGHTATV

Crispr_ID: CP033073_5

• CRISPR_ID: CP033073_5
• CRISPR_location: 2152877-2152963
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP033073_5

Consensus_repeat	Method
GGTGCCCACCCTGTTGTCGTGAC	CRISPRCasFinder

spacers of CP033073_5

>5.1|2152900|41|CP033073|CRISPRCasFinder
CGGGCTCGGCCGGGCATGACAAAGGGTGGGCACCTCCCGTG

CRISPR arrays and Neighbor proteins around CP033073_5

CRISPR arrays

The CRISPR arrays of CP033073_5

>merge|CP033073|5|2152877-2152963|CRISPRCasFinder
GGTGCCCACCCTGTTGTCGTGACCGGGCTCGGCCGGGCATGACAAAGGGTGGGCACCTCCCGTGCGTGCCCACCCTGTTGTCGTGAC

>CP033073|5|5|2152877-2152963|CRISPRCasFinder
GGTGCCCACCCTGTTGTCGTGAC	CGGGCTCGGCCGGGCATGACAAAGGGTGGGCACCTCCCGTG
CGTGCCCACCCTGTTGTCGTGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN39095.1|2140147_2140705_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN39106.1|2153815_2155075_-|serine-protease	unknown	unknown	gnl|CDD|274856
CP033073.1|AYN39107.1|2155126_2156917_-|hypothetical-protein	unknown	unknown	gnl|CDD|223021
CP033073.1|AYN39109.1|2158391_2160719_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN39108.1|2157804_2158317_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN43578.1|2161387_2161954_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN39102.1|2147069_2148578_-|type-VII-secretion-integral-membrane-protein-EccD	unknown	unknown	gnl|CDD|274855
CP033073.1|AYN39100.1|2146077_2146365_-|30S-ribosomal-protein-S15	unknown	unknown	gnl|CDD|180170
CP033073.1|AYN39101.1|2146640_2146934_+|DUF397-domain-containing-protein	unknown	unknown	gnl|CDD|377231
CP033073.1|AYN39098.1|2142135_2143515_-|insulinase-family-protein	unknown	unknown	gnl|CDD|223685
CP033073.1|AYN39103.1|2148878_2152844_+|type-VII-secretion-protein-EccCa	unknown	unknown	gnl|CDD|274858
CP033073.1|AYN43577.1|2160747_2161347_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN43575.1|2148767_2148980_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN39097.1|2141336_2142089_-|4-hydroxy-tetrahydrodipicolinate-reductase	unknown	unknown	gnl|CDD|234595
CP033073.1|AYN39099.1|2143511_2145731_-|polyribonucleotide-nucleotidyltransferase	unknown	unknown	gnl|CDD|131743
CP033073.1|AYN39104.1|2153020_2153323_-|WXG100-family-type-VII-secretion-target	unknown	unknown	gnl|CDD|274862
CP033073.1|AYN39105.1|2153361_2153703_-|hypothetical-protein	unknown	unknown	gnl|CDD|274862
CP033073.1|AYN43576.1|2156916_2157348_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN39096.1|2140873_2141326_-|hypothetical-protein	unknown	unknown	gnl|CDD|276809
CP033073.1|AYN39110.1|2162168_2162579_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN39106.1|2153815_2155075_-|serine-protease	gnl|CDD|274856	TIGR03921, T7SS_mycosin, type VII secretion-associated serine protease mycosin. Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair].	8.52787e-71
CP033073.1|AYN39107.1|2155126_2156917_-|hypothetical-protein	gnl|CDD|223021	PHA03247, PHA03247, large tegument protein UL36; Provisional.	3.04881e-07
CP033073.1|AYN39102.1|2147069_2148578_-|type-VII-secretion-integral-membrane-protein-EccD	gnl|CDD|274855	TIGR03920, T7SS_EccD, type VII secretion integral membrane protein EccD. Members of this family are EccD, a component of actinobacterial type VII secretion systems (T7SS) with ten to eleven predicted transmembrane helix regions. [Protein fate, Protein and peptide secretion and trafficking].	7.18396e-26
CP033073.1|AYN39100.1|2146077_2146365_-|30S-ribosomal-protein-S15	gnl|CDD|180170	PRK05626, rpsO, 30S ribosomal protein S15; Reviewed.	1.63403e-52
CP033073.1|AYN39101.1|2146640_2146934_+|DUF397-domain-containing-protein	gnl|CDD|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	9.79138e-09
CP033073.1|AYN39098.1|2142135_2143515_-|insulinase-family-protein	gnl|CDD|223685	COG0612, PqqL, Predicted Zn-dependent peptidases [General function prediction only].	1.08649e-118
CP033073.1|AYN39103.1|2148878_2152844_+|type-VII-secretion-protein-EccCa	gnl|CDD|274858	TIGR03924, T7SS_EccC_a, type VII secretion protein EccCa. This model represents the N-terminal domain or EccCa subunit of the type VII secretion protein EccC as found in the Actinobacteria. Type VII secretion is defined more broadly as including secretion systems for ESAT-6-like proteins in the Firmicutes as well as in the Actinobacteria, but this family does not show close homologs in the Firmicutes. [Protein fate, Protein and peptide secretion and trafficking].	0
CP033073.1|AYN39097.1|2141336_2142089_-|4-hydroxy-tetrahydrodipicolinate-reductase	gnl|CDD|234595	PRK00048, PRK00048, dihydrodipicolinate reductase; Provisional.	2.899e-100
CP033073.1|AYN39099.1|2143511_2145731_-|polyribonucleotide-nucleotidyltransferase	gnl|CDD|131743	TIGR02696, polyribonucleotide_nucleotidyltransferase, guanosine pentaphosphate synthetase I/polynucleotide phosphorylase. Sohlberg, et al. present characterization of two proteins from Streptomyces coelicolor. The protein in this family was shown to have poly(A) polymerase activity and may be responsible for polyadenylating RNA in this species. Reference 2 showed that a nearly identical plasmid-encoded protein from Streptomyces antibioticus is a bifunctional enzyme that acts also as a guanosine pentaphosphate synthetase.	0
CP033073.1|AYN39104.1|2153020_2153323_-|WXG100-family-type-VII-secretion-target	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	1.19519e-13
CP033073.1|AYN39105.1|2153361_2153703_-|hypothetical-protein	gnl|CDD|274862	TIGR03930, WXG100_ESAT6, WXG100 family type VII secretion target. Members of this protein family include secretion targets for the two main variants of type VII secretion systems (T7SS), one found in the Actinobacteria, one found in the Firmicutes. This model was derived through iteration from pfam06013. The best characterized member of this family is ESAT-6 from Mycobacterium tuberculosis. Members of this family usually are ~100 amino acids in length but occasionally have a long C-terminal extension.	2.89731e-05
CP033073.1|AYN39096.1|2140873_2141326_-|hypothetical-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	0.00415287

Protein sequences

>CP033073.1|AYN39103.1|2148878_2152844_+|type-VII-secretion-protein-EccCa
MSQIVVKRPPRALPSEVPTEEVVVQPPPELPRGHQESVLMQLLPTLGMGGSVVFFFTNGQPFMKIMGMIMIASTVGMSIAMVVRFRRGSQGQLADMRRDYLSYLSQTRKSAVRTAKAQRDAQYYLHPSPEQLWALVAEGSRVWERRPGDEDFAHVRIGLGPQPLATPLVAPETGPVEQLEPLTAGAMQRFLAAHHSVGDLPMAVSLRAFYHVTVSGEPQSVRASARALVGSLASLHSPQDLTIAVAAGREALPHWDWAKWLPHVQAPGAVDGAGSRRLIGADPRELEDLLATRLTGRPRFHPGAGPLLDEPHIVLVLDDLSLLPDSVLANPEGLQGVTVLEVVPGDLTTAGGDLSIVVQPGLLRLESGHGEVYDGTPDALSYESAEALARQLAPLRMASGGDDDEPLLANLEFTDLLGLGDAASVDTKRTWRPRALAERLRVPIGVGEDGRPVMLDLKEAAQEGMGPHGLCVGATGSGKSELLRTLVLGLAVTHSSETLNFVLADFKGGATFAGMAQMPHVAAVITNLADDLTLVDRMGDSIRGELNRRQELLRDAGNYANIHDYEKARAAGAPLQPIPSLVLVIDEFSELLSAKPDFIEMFVQIGRIGRSLGVHLLLASQRLEEGRLRGLETYLSYRIGLRTFSAAESRAALGVPDAYELPNVPGSGFLKYGTDEMVRFKAAYVSGVYRSGPQRGALTGGQLPVDRRPVLFTATEVPVRYTAVPQQRAHTEAAVDEALADTVLDVIVRRLEAQGPAAHQVWLPPLESPPSLDALLPGLAAVQGRGLTQPGYEGAGRLVVPAGLVDKPYEQRRDRLMLDFSGAAGHMQIVGGPQSGKSTLLRSLICSFALTHTPYEVQFYGLDFGGGGMTAVAGLPHVGGIASRLDPERVRRTVSEVYGVLTRREEYFRTAGIASIADYRARRARGDISVADQPWGDVFLVIDGWGNFRADYEALETAVLDIAARGLGYGIHVIITASRSMEVRANFKDHLMNRLELRLGDVMDSEIDRKVAVNVPAGVPGRGLSPQKLHFMAAVPRIDGLTSDTDLAEATAALTTEVGRHWQAPGAPEVRLLPRQLEAVELPSGERFPQRGIAFALDEENLEPVFLDFEQDPFFLVFGESESGKSNLLRLLIKQLTLRYGGDEAKFFVVDNRRSLLDITPASHLAEYIPMSSQMEHHMVALADLMQRRTPTADVTPQQLRDRSWWRGPQVFVVIDDYDLVSNSSGNPLSGLTEMLPFARDVGVRFIIARSTAGAGRAAYEPFMQRMKELGAQGVVLAGDPAEGDILNGVRPRPMPAGRGVFVSRKRGKPLVQTGLVDVEY
>CP033073.1|AYN43575.1|2148767_2148980_-|hypothetical-protein
MPPRQFRRWLDDDLFRGHLGRQRPGRALHDNLAHRSPIPLPDPGIPHATPCPASAGRRVILLSSRDTGER
>CP033073.1|AYN39102.1|2147069_2148578_-|type-VII-secretion-integral-membrane-protein-EccD
MTAAATGGPGTGAPSGSGTGTGLGFCRVTIVAPDSRIDVALPDDVPVADLYPEILRLSQQSPTAGAPVGYHLVRTDGTVLDSARSFAAQRILDGELLTLRPFADSLPPAVHDDVAEAVASSVTRQHKLWSGDLTRAAGLVGGGVLPALLAFVAWTADPLHDMHGLAGILAAVTGVLLVVLSAVRARVYDDRGSAVALGLGALPNIGVAGSGLLPLSDGEGIGRLQFLLACAAVLVAALILALCAPHGDGPFVAFVFASAIALVAVFAATLTGWAPTETAALCAPVAVGALAFLPGMSMRFARLPIGFENPSSGTSRSAYGTEAAAQEPVDTERVEAQARRGHELLVGLVGGCALLAVGASAVLGFSDDVWAQLLAFATGVAMLMRAGLFRYTAQVASVLAAGLASLVLLGLGLALNPPQHVMRAALAGDRTDLDIRTVWLIAVIALATALVTALGLILPRGGPTPFWGRFLEICEGFVLLTLIPLALAVFDVYATARSMTSS
>CP033073.1|AYN39101.1|2146640_2146934_+|DUF397-domain-containing-protein
MAETEAEIKARKERERDELYGLDISGAEWHCAPGTEEHEERVEIAYLPGGAVAMRSSLDPDTVLRYTEAEWRAFVLGARDGEFDLKPMAHNGGLDAQ
>CP033073.1|AYN39100.1|2146077_2146365_-|30S-ribosomal-protein-S15
MSLDAATKKQIITEFGTKEGDTGSPEVQVAMLSRRISDLTEHLKTHKHDHHSRRGLLILVGQRRRLLQYLAKKDIQRFRALVDRLGIRRGAAGAK
>CP033073.1|AYN39099.1|2143511_2145731_-|polyribonucleotide-nucleotidyltransferase
MENETHYAEAVIDNGSFGTRTIRFETGRLAKQAAGSAVAYLDDDTMVLSATTASKNPKDQLDFFPLTVDVEERMYAAGKIPGSFFRREGRPSEDAILTCRLIDRPLRPSFKKGLRNEIQVVATIMALNPDHLYDVVAINAASASTQLAGLPFSGPIGGVRVALIRGQWVAFPTHTELEDAVFDMVVAGRVLEDGDVAIMMVEAEATDKTIKLVEGGAEAPTEEVVASGLDAAKPFIKVLCRAQADLAAKAAKPTGEFPVFLDYQDDVFEALTAAVRPELAQALTIAGKQDREAELDRVKALAAEKLLPEFEGREKEISAAYRSLTKQLVRERVIKEKKRIDGRGVTDIRTLAAEVEAIPRVHGSALFERGETQILGVTTLNMLRMEQQLDTLSPVTRKRYMHNYNFPPYSVGETGRVGSPKRREIGHGALAERAIVPVLPTREEFPYAIRQVSEALGSNGSTSMGSVCASTMSLLNAGVPLKAPVAGIAMGLISQEINGETHYVALTDILGAEDAFGDMDFKVAGTKEFVTALQLDTKLDGIPASVLAAALKQARDARLHILDVMMEAIDRPDEMSPNAPRIITVKIPVDKIGEVIGPKGKMINQIQEDTGAEITIEDDGTIYIGAQVGSQAEAARATINGIANPTMPEVGERYLGTVVKTTTFGAFVSLLPGKDGLLHISQIRKLAGGKRVENVEDVLGVGHKVQVEIAEIDSRGKLSLIPVIEGEEGDETAKDDADQ
>CP033073.1|AYN39098.1|2142135_2143515_-|insulinase-family-protein
MTSRSSKATARTSSEARAVARTQTLVKGTGGIGTVRRTTLPGGLRIVTETLPSVRSATFGIWAHVGSRDETPALNGATHYLEHLLFKGTSRRSALDISSAVDAVGGEMNAFTAKEYTCYYARVLDTDLPLAIDVVCDMLTGSLIREEDVDVERGAILEEIAMTEDDPGDCVHDLFAQTMFGNNALGRPVLGTVDTVNALTADRIRRFYRKHYDPTHLVVACAGNIDHNKVVRQVRAAFEKAGALGNTDARPIAPRDGRRAIRTHGKVDLLARRTEQAHVVLGMPGLARTDDRRWAMGVLNTALGGGMSSRLFQEVREKRGLAYSVYSYTSGFADCGLFGVYAGCRPSQVHDVLRICRDELDHVADNGLSDDEIARAVGQLRGSTVLGLEDTGALMNRIGKSELCWGEQMSVDDMLASIAAVTPDEVRSVARDILGQRPSLSVIGPLKDKQAARLHDAVA
>CP033073.1|AYN39097.1|2141336_2142089_-|4-hydroxy-tetrahydrodipicolinate-reductase
MSKLRVAVLGARGRIGSEAVRAVEAAEDMELVAALGRGDELRTLTETGAQVAVELTTPASVMDNLDFCVSHGIHAVVGTTGWTEERLTRLRDQLARSPRTGVLIAPNFSIGAVLTMKFAQIAAPYFESVEVVELHHPNKVDAPSGTATRTAQLIAEARRAAGTAPAPDATVTALDGARGADVDGIPVHAVRLRGLLAHQEVLLGAEGETLTVRHDSLHHSSFMPGILLAARRVVTTPGLTYGLEHFLDLS
>CP033073.1|AYN39096.1|2140873_2141326_-|hypothetical-protein
MRAKITYLVTAAVLVFYFLLVGSRGVMLIQSGTLLTVTFGVAVLILPVIGLWFLWKNTQFVRRANRLAAELDAEGGLPVDELKRMPSGRIDRDSADEVFARRKAETEESPDDWRCWFRLAVAYHDAHDTPRARKAMQRAIALHDGEPVRT
>CP033073.1|AYN39095.1|2140147_2140705_+|hypothetical-protein
MPLPFLTADRTFETASESALPYDDPDRWRRPYRPGPWRVGVAALGLLLASFVLSAAVLIAPAGRLSSAGAVLAGGLAIVAGALRLLRMGVWVSGRGLRRVGPLLTRTVPWARVASVRTVQQPVRWLGLPRTVQGQALVLVREDRRPDDDAAPLLTTHGLDFLGRPAAFDRAADTVEAWAAENRRG
>CP033073.1|AYN39104.1|2153020_2153323_-|WXG100-family-type-VII-secretion-target
MGVNNSGELEVSYGSLDETATQLANHARRLEEGLEAIKQKVAGVASMWEGEAHNAYTEQQTAWDREAKGIHEALVQIGKVVHAAGGDYQGGDRKAASYFM
>CP033073.1|AYN39105.1|2153361_2153703_-|hypothetical-protein
MATQRQKVSDKDIIVLEKELLHRFEGIKGQLKELQALIDSLEGNWKGIGAGAFNSKQTEINERMVRIGNILAKFIEAMSTTRKIKDGTEDEVRSQVQSIDVDLGGAHSALSSY
>CP033073.1|AYN39106.1|2153815_2155075_-|serine-protease
MGTALLTRRNAIRLSAVCSVLGTLVITSAGLAPGAAASDGVQSKQWYLDAMHADEMWKHSTGKGVKVAVIDTGVNPQTSSLKGQVLVDEVPKAAKYHVTQDYDGHGTTMAEIIAGTGAGGGIKGLAPGARIIPIRVGLDELKDANERARSLTSAKAIRAAADSDAKIINMSYGSVYYNGDEEDALKYAASKGKLLFSSIGNSGDAGNKPDYPAKDPYAIGVSAVDKTGTVGKLSTFGNYVDMSAPGLNVPAWCDNAFTRYCTTEGTSHASAIASASAALVWSAHPDWTANQVLRSLIDTAGRTWPKGKPSKYLGYGLMRPRMVLADKNFDPGPADRDPLAAENGTAPDEDITATKSPAASPTAKTPAKDTGSSSGPASAAAKDADSGDSTQTWVIIGAVAAVLVIAGAGFAVMRARRNA
>CP033073.1|AYN39107.1|2155126_2156917_-|hypothetical-protein
MSDNWQQKPEYRTDVEQANNQVGVVNKLSRFQNAFRGTPIGAALSFGRTDFEDHDLNAMIDLVHHSNPEHLETASKALWDARTAIHDAATDLETHLRGVDWQGEGADSFHKWTSGLIDWTKGLASFADAAATEISAAATGLASVRKSMPPRDTRPASEQKRPTQLPKTKQVDGNPDYAAALAVEKNRQEAINQANRLASFYSVSASALGMAMASDPKPYSPIPDVGVPQPTRRRDGDLRGSGAASSSPTAVRRSVAASHGSVAEGHHVTATSHGTPTVNGTETGGHVPPLKEVPEPSAPSGPDVGTEINTTTTLPPQTPAAPSGSPAPTLPTTAGGGGQVPLPPGPMSPPVAPTSGRTPGYGPTSRFPVSAQGRTGPSGAGSGRVPQGPAGQTGRSVAGGRAPQGPMGQAARATGRATPAGQPGVRGAAQSGRAPMGRGVTGGTPRPANTPGGRAGTAGPTGAARNGVVGGKPVTGRTSGGTANPRVPRGMVVGAEEPVTSQPSKGALGQRGVVGAPTAKAEPGASQAVLRSAGNPEGAIGAPRNTAGSPLKGSEAGAKGLGRGAVGGRQGASGAPAEKEEHRSSRQRRDEPQTSD
>CP033073.1|AYN43576.1|2156916_2157348_-|hypothetical-protein
MRRGIDALSKFKRKVDDALKAFEGAPGSPSRLAEHTLNLGSFSGSNIPFHEATELHGRYEQVHERLTSLSKNLSMQIEALTLAAHAADVTYDGTEDEVRRRFWEIRAHLEAEHRKAQAEEKHAQEKPAAAEHSGGTKSAGGKF
>CP033073.1|AYN39108.1|2157804_2158317_+|hypothetical-protein
MAWDEWEQLKAQAAEGQSAHMQLNHVDGGGGTYGPYVLPSTTGDLKVGHKDLEKIGSAAHHLYNQLWDKARVATPSSDSAAGDLSQQGFALGAGLQHVSTRWEDQLKSLMDACAQISNHMQTTKAVHANDEHYIQRQMSSIDALDAGFDERVGAPGKKNSVYGEKSKKKE
>CP033073.1|AYN39109.1|2158391_2160719_+|hypothetical-protein
MDFNALFHANFKLFDDAVTDWSTLVKHLADLKKDAEDGLHKAALAADWAGVNAQVSREFIGKTAGEFGDAHTQATTIHNILRDTRDELKTFHQQLTDAVSRGQKKNLTVADAGDGKFTVMGNTRPDWNSDPSGKTSTTDQKDVDDLRDEIQGILSKATESDNTAKDVLAAIVDQSATGFSDANYKDRDTAADAVKEADELAKLAGKNPDDLSVEDFDRINSGLKKYANDPLFAERFTTDLGPQKTLEFWTGISDPNRGNYELGHKRLDQFDDLQRNLGLTLAHATQSDSAGMTEWKRKMIDIGDQPLYGDRGGPMGFQVMSNLMRTGDYDDQFLKDYGTELMVAERKMTGNGEHGNPIWQHMGGSAWLNRIGDDSGNDALTGYLKGLSNSPDAATDFLNQQYVSKDDPDNPFERDTDGNGKKGKVSLSNFQYLFEERDWPKEANLHGDDIITGQNNLALALEAATTGHPAGEMPTADTPPHNAGQAKLVEDIFQSVSEDPKRLTGRSYMSDSMGQIAAEYMPDIHRELHAGDASEKTLFPVAGTVAMLNERDITRFLYAVGQNPEGYAAVNLGQHSYTTQLMQHHFEHPGEYVKDPAFSEADNLKQGSEQIARKAGEIEGIIGAGRAYQAELEGGAKDADYNAAIERAGSWGGTAIGIGIGMATEPMTGPGGAIIGDVAGTAADEIIGKITEGAMQDSSGEIIYRNGESFEETSDSTYKLVELAARKAGENSGHRYPLIEASVATAAEDGFDTAGTKVHKYLDGEGIPRQLDTED
>CP033073.1|AYN43577.1|2160747_2161347_+|hypothetical-protein
MLAGGAALLLCLVLGVLYALGLPPFKDKRGEIKASEMCGTLGRSSSTAAALKRVLPDKSSYAFDGAVTDPRLDDVDSSYYASCFVNGDGKQLVAVTAEMMQYDKADEWVKDVVAENTPAGSMTPFGAGDKAVASDKVAAIYFPCVARGVGDHMSVVVHLKRPGSADGDQLRKGLISLARNAALVAHQKAKCDAPSKLTH
>CP033073.1|AYN43578.1|2161387_2161954_+|hypothetical-protein
MNVTSGPYQGRRAGAAISVAVLLFTLTSCSGSEQGREYATPRSVCGVAVDADALAGFLPPGNKVTAKATAAPPAATRCTVSVDGTPIVRTAQEWWNDMSVLEFAEGVTLDEVGHRTDDGRFAYSGNEAFGKTEHCRDHHDRILYTAVRATGSEHEDAAAMKELITEYTDAVQRSSVCHGSSTTPAAGG
>CP033073.1|AYN39110.1|2162168_2162579_+|hypothetical-protein
MRLNQAATDGGGGSGDLVVHQDDLGRVGHEADLLFEDLKGQADIAAAGSGNGSVGSTMQAAAALKSHGFQMGSALETTVEVWTTQVKAVLQARAHISDHLDFTQKLHAEDGAEIGATLRGRDGSAVSVSQLNEYFK

Crispr_ID: CP033073_6

• CRISPR_ID: CP033073_6
• CRISPR_location: 2906383-2906470
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP033073_6

Consensus_repeat	Method
ATCCAGCACCGATCCAGCACGGT	CRISPRCasFinder

spacers of CP033073_6

>6.1|2906406|42|CP033073|CRISPRCasFinder
GCGGGTGATGGGGGGTGATGACGGGTGACGAGGTGTCAGATT

CRISPR arrays and Neighbor proteins around CP033073_6

CRISPR arrays

The CRISPR arrays of CP033073_6

>merge|CP033073|6|2906383-2906470|CRISPRCasFinder
ATCCAGCACCGATCCAGCACGGTGCGGGTGATGGGGGGTGATGACGGGTGACGAGGTGTCAGATTATCCAGCACCTATCCAGCACGGT

>CP033073|6|6|2906383-2906470|CRISPRCasFinder
ATCCAGCACCGATCCAGCACGGT	GCGGGTGATGGGGGGTGATGACGGGTGACGAGGTGTCAGATT
ATCCAGCACCTATCCAGCACGGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN39652.1|2911637_2911907_+|exodeoxyribonuclease-VII-small-subunit	unknown	unknown	gnl|CDD|179195
CP033073.1|AYN39639.1|2900303_2901149_+|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
CP033073.1|AYN39649.1|2908437_2909184_-|ROK-family-protein	unknown	unknown	gnl|CDD|224851
CP033073.1|AYN39643.1|2902547_2903348_+|diaminopimelate-epimerase	unknown	unknown	gnl|CDD|234768
CP033073.1|AYN39650.1|2909213_2910230_-|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	unknown	unknown	gnl|CDD|234893
CP033073.1|AYN39648.1|2907978_2908395_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN39645.1|2904996_2905359_+|UDP-N-acetylmuramoylalanyl-D-glutamate--2,-6-diaminopimelate-ligase	unknown	unknown	gnl|CDD|223841
CP033073.1|AYN39653.1|2912205_2912796_+|malonic-semialdehyde-reductase	unknown	unknown	gnl|CDD|180040
CP033073.1|AYN39651.1|2910432_2911641_+|exodeoxyribonuclease-VII-large-subunit	unknown	unknown	gnl|CDD|272979
CP033073.1|AYN39640.1|2901241_2901625_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN39647.1|2906556_2907645_-|redox-regulated-ATPase-YchF	unknown	unknown	gnl|CDD|236583
CP033073.1|AYN43624.1|2899822_2900275_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN39646.1|2905451_2906267_-|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl|CDD|376667
CP033073.1|AYN39644.1|2903344_2904436_+|ATP-grasp-domain-containing-protein	unknown	unknown	gnl|CDD|234948
CP033073.1|AYN39656.1|2915033_2915408_-|WhiB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376791
CP033073.1|AYN39655.1|2913519_2914554_+|class-II-fructose-bisphosphatase	unknown	unknown	gnl|CDD|236536
CP033073.1|AYN43625.1|2904472_2904997_+|hypothetical-protein	unknown	unknown	gnl|CDD|239109
CP033073.1|AYN39642.1|2902246_2902492_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN39654.1|2912860_2913400_-|DUF4245-domain-containing-protein	unknown	unknown	gnl|CDD|379430
CP033073.1|AYN39641.1|2901621_2902164_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239646

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN39652.1|2911637_2911907_+|exodeoxyribonuclease-VII-small-subunit	gnl|CDD|179195	PRK00977, PRK00977, exodeoxyribonuclease VII small subunit; Provisional.	7.32851e-18
CP033073.1|AYN39639.1|2900303_2901149_+|XRE-family-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	2.13843e-08
CP033073.1|AYN39643.1|2902547_2903348_+|diaminopimelate-epimerase	gnl|CDD|234768	PRK00450, dapF, diaminopimelate epimerase; Provisional.	1.41107e-60
CP033073.1|AYN39650.1|2909213_2910230_-|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase	gnl|CDD|234893	PRK01045, ispH, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed.	0
CP033073.1|AYN39649.1|2908437_2909184_-|ROK-family-protein	gnl|CDD|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	1.3987e-33
CP033073.1|AYN39645.1|2904996_2905359_+|UDP-N-acetylmuramoylalanyl-D-glutamate--2,-6-diaminopimelate-ligase	gnl|CDD|223841	COG0770, MurF, UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane].	8.80429e-21
CP033073.1|AYN39653.1|2912205_2912796_+|malonic-semialdehyde-reductase	gnl|CDD|180040	PRK05365, PRK05365, malonic semialdehyde reductase; Provisional.	2.99864e-102
CP033073.1|AYN39651.1|2910432_2911641_+|exodeoxyribonuclease-VII-large-subunit	gnl|CDD|272979	TIGR00237, exodeoxyribonuclease_VII_large_subunit, exodeoxyribonuclease VII, large subunit. This family consist of exodeoxyribonuclease VII, large subunit XseA which catalyses exonucleolytic cleavage in either the 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. Exonuclease VII consists of one large subunit and four small subunits. [DNA metabolism, Degradation of DNA].	4.06409e-157
CP033073.1|AYN39647.1|2906556_2907645_-|redox-regulated-ATPase-YchF	gnl|CDD|236583	PRK09601, PRK09601, redox-regulated ATPase YchF.	0
CP033073.1|AYN39656.1|2915033_2915408_-|WhiB-family-transcriptional-regulator	gnl|CDD|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	5.32622e-20
CP033073.1|AYN39644.1|2903344_2904436_+|ATP-grasp-domain-containing-protein	gnl|CDD|234948	PRK01372, ddl, D-alanine--D-alanine ligase; Reviewed.	7.32547e-68
CP033073.1|AYN39655.1|2913519_2914554_+|class-II-fructose-bisphosphatase	gnl|CDD|236536	PRK09479, glpX, fructose 1,6-bisphosphatase II; Reviewed.	0
CP033073.1|AYN43625.1|2904472_2904997_+|hypothetical-protein	gnl|CDD|239109	cd02549, Peptidase_C39A, A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage is mediated by the transporter as part of the secretion process. Bacteriocins are antibiotic proteins secreted by some species of bacteria that inhibit the growth of other bacterial species. The bacteriocin is synthesized as a precursor with an N-terminal leader peptide, and processing involves removal of the leader peptide by cleavage at a Gly-Gly bond, followed by translocation of the mature bacteriocin across the cytoplasmic membrane. Most endopeptidases of family C39 are N-terminal domains in larger proteins (ABC transporters) that serve both functions. The proposed protease active site is conserved in this sub-family of proteins with a single peptidase domain, which are lacking the nucleotide-binding transporter signature or have different domain architectures.	3.74618e-08
CP033073.1|AYN39646.1|2905451_2906267_-|sulfite-exporter-TauE/SafE-family-protein	gnl|CDD|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	2.49915e-12
CP033073.1|AYN39654.1|2912860_2913400_-|DUF4245-domain-containing-protein	gnl|CDD|379430	pfam14030, DUF4245, Protein of unknown function (DUF4245). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 188 and 235 amino acids in length.	3.497e-49
CP033073.1|AYN39641.1|2901621_2902164_+|NUDIX-hydrolase	gnl|CDD|239646	cd03674, Nudix_Hydrolase_1, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, U=I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	0.000132305

Protein sequences

>CP033073.1|AYN39646.1|2905451_2906267_-|sulfite-exporter-TauE/SafE-family-protein
MAFDQNVVPLRSTHATPVVFGAGAAIGVLGGMIGLGGAEFRLPLLISLFGFAALSAVILNKAMSLVVVLVALPARLAAVPAVELAARWPVAVNLLAGSLLGAWAGASWAVRMRSATLYKVLAALMVLMAAALMVTHTTTLGTLDLPLWAQVPCGVVAGFGIGVVAAIMGVAGGELLIPTIVLLFGEGIKTAGSISLLVSLPTMLVAFARYSRDGSFAVLGANLRFAMIMAAGSIVGAVLGGLLLGVFPDLVLIPALAVILLISAVKLARHD
>CP033073.1|AYN39645.1|2904996_2905359_+|UDP-N-acetylmuramoylalanyl-D-glutamate--2,-6-diaminopimelate-ligase
MPETDGDATEAVGGRRIAVLGEMLELGEEAVEAHREIGRFAAESGVDLVVAVGGDLAKQLALAAGAAGVPDIAFVGDNATAAAYLDSILQPGDVVLVKASRGGQLWQIAQALNGQPVTGL
>CP033073.1|AYN43625.1|2904472_2904997_+|hypothetical-protein
MCRQLIAPAEWDLHGGWALGDRIEWSNRACGLASLRAILLAYGREAPTVTELLKLAVKHEVLTPRGALHAGIANLATELGVPSLAEPIPAENLLGRLDDAPLIVSVTEQFPDDGRTGGHLVILRGYDDGPEPVIRFRDPSAWGQSHDRVPLSRLSASYTGRAITFAPLTNNGDS
>CP033073.1|AYN39644.1|2903344_2904436_+|ATP-grasp-domain-containing-protein
MTLFLDSSSKQAAHKATEELRAWRQSRRGLSVALIYGPVSAEDRLYHSKCPVEQRSVTALGEALEEIGARWDVLDPTQPDFISELVSYDVALSNLHGPYGEDGRLQGLLDYLRVPYCGSGVAASAVAADKILCKRVMLTLGVPTPGWRVWSGGPVNWASQAVMVKPPFGGSSVGMSLVRDAADLPRALAEAAGESGEEVLVEDYVIGTPVTVGMLELPGGSVIVFPPLTTEATDAEFYDADTKLDVDSKGAVTVRAAELEPVALNRIARDARTLWDGIGLRGSARIDFIVTEDGDAYVLEVNSTPGMSRDSNFAVGAAMVGLTHTDVVLAMLHEALARPPYDVPLPTPVFSSTTATREAAVSL
>CP033073.1|AYN39643.1|2902547_2903348_+|diaminopimelate-epimerase
MRFRKIHGAGNDFILFTDPGPRAGTDWAKEAERLCARRTGVGADGLVVSRFVSPTSTVLDVDCFNADGSTATMCGNALRCAAWAAQCDQGFRTMQLRMAGVMHEATVDADSVWVTADVGAIQPRVLQTVINGRPTWFDSAHTGTEHVVAVVENVDAIHTEVVGRVVRHHKNVAPLGTNVNFVQHLGGQALKIRTYERGVEAETLSCGSGAVAAVVIATMRGLVARREVTVHNEAGEPLTVRPHDDHPNRAAWVGGPVTQTFEGVLA
>CP033073.1|AYN39642.1|2902246_2902492_+|hypothetical-protein
MYQPRSEEQPSEPPPPVGTMKATRTPTDVRIGDFILIDGSYQRVRDMRAAGTSAHRVLHFVGHAPLIMRKPQTVCRPISSR
>CP033073.1|AYN39641.1|2901621_2902164_+|NUDIX-hydrolase
MSVREDQIIRELSHYIHEHPDEKMALMPVYDAAVDHSRNRGCTHDQRCPLVMAGAVVVDEQARVLCLRHEGGYALAEAEPEDQDNSLSEAALRLLAEEVGVWDVWTEPGAEGPFLVDVTRPGQHGYGRRLRVGMRYLFRAHSGAVFPSMIEAGAAAWVPLPEIGIPSVRRRVEHHLIGTR
>CP033073.1|AYN39640.1|2901241_2901625_+|hypothetical-protein
MKVASTGKARELAEVSEENGGISVTEITSLTDTVLGFRLGTTTRAQLDHYVPRLAKELNGLLGKDLGAEDDPDAQELVRRATRLVELSARPTAETPTFGTFFYLRDIANLSRRLLWLYTDRHGLGAP
>CP033073.1|AYN39639.1|2900303_2901149_+|XRE-family-transcriptional-regulator
MKPPASSSAQEARKALGKRLAEIREAAGLTKRALSAKLDWHESKASRFESGTRAPSERDLRAWCRVCEADSLADDLVKTARGIEGMYVEWHKMEGDGLKWAQESALPLWERTQHFRFYSPSLIPGPVQTASYIKALLTSIRNRRGLIDDVDAAVEVRLEKQKIVYTPRTFVILLEESALYNRIGGTDVMAGQLGYLISAMALPTVSIGIIPRDIDRPLMPVEGFFMFDDHTVKVELVSAHLTVVQKHELAMYARTFTELHEHAVIGSAARELITRAIESQG
>CP033073.1|AYN43624.1|2899822_2900275_+|hypothetical-protein
MEARDAYSKTDSAFVDWKAGKSIDPAKRWAAWHAIVSEAVSRGVEVRRARIVSTPVSEYIRFEHEVTEGLNVAAGEQVRWLPRRNASDLLLPGNDFWLFDSRLLYLNHFDGEGEPTEPEITEDPEIAKLCDTAFEAVWNRATPHAEFAAY
>CP033073.1|AYN39647.1|2906556_2907645_-|redox-regulated-ATPase-YchF
MSLTIGIVGLPNVGKSTLFNALTKNDVLAANYPFATIEPNVGVVGVPDARLAQLASIFKSERILPATVDFVDIAGIVRGASEGEGLGNKFLANIRESDAICQVIRAFKDENVVHVDGKVSPKDDIETINTELILADLQTIEKVLPRLQKESRIKKDIAPKVRAVEEAKEILEKGDTLFAHGIVQGSERAELLHDLHLLTTKPFLYVFNVDEDELVDEEFKNEQRALVAPAEAIFLNAKLEADLAELDEEEALELLQSVGQDEPGLATLARVGFATLGLQTYLTAGPKESRAWTIKKGATAPEAAGVIHTDFQKGFIKAEVISFDDLVETGSVTEARAKGKARMEGKDYVMQDGDVVEFRFNV
>CP033073.1|AYN39648.1|2907978_2908395_+|hypothetical-protein
MRPARPAGAGGRPADMKLTGLGSGLFCVVAMFLLGYLDQLLLGASGTVYGLLFLPVCLLTALWVRDGDVLTAPVVAPIAFTLGLLPLADGAGGLAGRMMGLFTGLATQAGWLYAGTLAAGVTVLVRRTRWAEQRRRRS
>CP033073.1|AYN39649.1|2908437_2909184_-|ROK-family-protein
MQIFGVDIGGSGIKGAPVDLDRGDLAQERCKVLTPHPATPDGVADGVKQVIDHFGWTGPVGLTFPGVVTGGATIRTAANVDKSWIDTDARALFSGRLGGLPVTVVNDADAAGVAEMQFGAGRGRRGTVILLTFGTGIGSALFVDGVLVPNTELGHLELHGHDAEKRASSKVKEDHDLSWEQWAQRVQQYLAHVEMLFSPELFVIGGGVSRKAHKFLHLIEGVKAEIVPAQLQNNAGIVGAAMRAAPRG
>CP033073.1|AYN39650.1|2909213_2910230_-|4-hydroxy-3-methylbut-2-enyl-diphosphate-reductase
MGRMTASPGRRVLLAAPRGYCAGVDRAVIAVEKALEQYGAPIYVRHEIVHNKYVVQTLEKKGAVFVERTDEVPPGNIVMFSAHGVAPVVHDEARQGRLATIDATCPLVTKVHKEAVRYANDDYDILLIGHEGHEEVIGTSGEAPDHIQLVDGPEDVAKVEVRDPSKVVWLSQTTLSVDETMETVDALTAKFPGLVSPPSDDICYATQNRQLAVKQMGAEAELVIVVGSRNSSNSKRLVEVAKLAGAREAYLVDFAGEIDEAWLEGVRTVGVTSGASVPEVLVEQVLEWLAERGYADVEIVKAAEESITFSLPKELRRDLREEAAALAAERGGTGTPGA
>CP033073.1|AYN39651.1|2910432_2911641_+|exodeoxyribonuclease-VII-large-subunit
MAVNTSPEAPLPVGAVSRMIGGWIDRLGAVWVEGQITQLSRRPGAGVVFLTLRDPSHDISVGVTCYRQVFDAVADVVGEGARVVALAKPEWYAPRGQLSLRAAEIRPVGVGELLARLEQLKKALAAEGLFAPERKKPLPFLPQLIGLVCGRASAAERDVLENARHRWPAVRFEVRNVPVQGVHAVPQVVQAVKELDAVDEVDVIIVARGGGSVEDLLPFSDEQLVRAVAGCRTPVVSAIGHEPDNPLLDHVADLRASTPTDAAKKVVPDVGEELERVRMLRDRARRCVNASVEREERGLAHALARPSMEDPHRMIDVRADQVGSLADRSRRTVGHLLDRADSELTHTHARVVALSPAATLHRGYAVLQRADGHVVRDAAEVAEGETLRARVADGEFTVKVGE
>CP033073.1|AYN39652.1|2911637_2911907_+|exodeoxyribonuclease-VII-small-subunit
MTDKVDEALSYEQARDELIEVVRRLEAGGTTLEESLALWERGEELARVCRRWLEGARARLDAALAEEEDEGEGEGEGEAGPAKDGERAG
>CP033073.1|AYN39653.1|2912205_2912796_+|malonic-semialdehyde-reductase
MSLVLDPAAQDLLFREARTANTFTDEPVTDEQVQAIYDLVKYGPTAFNQTPLRITLVRSAEARERLLPHMAEGNRAKTAAAPLVAILAADNEFHEELPALFPAFPQAKDLFFAERPARESAAALNAALQAAYFVVGVRAAGLAAGPMTGFDFEGVRKEFLDDDHTPLMIVNIGRPGPDAWYPRSPRLAYEDVVTTV
>CP033073.1|AYN39654.1|2912860_2913400_-|DUF4245-domain-containing-protein
MVDVAGSNGKQKTARDMIVSLALIGIAAAVVYFLALPHNDHSPDLKRVDYRVELITARRAVSYPVAAPEGLPDTWKATSVRFQGQNSDRWHLGFQTPDGQYVQVEQSSTQKPAEFIEQASQGASATRRTEKAGGRTWTRYTGGRYDALVLQGAPGSTTVVAGTASFEELTAMAAALRME
>CP033073.1|AYN39655.1|2913519_2914554_+|class-II-fructose-bisphosphatase
MTENHQLPSELDVPSEAPDRNLALELVRVTEAAAMAAGRWVGRGDKNGADGAAVRAMRTLVSTVSMNGVVVIGEGEKDEAPMLFNGEHVGDGTGPEVDIAVDPIDGTTLTAKGMPNAIAVLAAAERGGMFDPSAVFYMDKLVTGPEAADFVDIDAPVAVNIRRIAKAKRSAPEDVTVVILDRPRHEGLIREVREAGARIKLISDGDVAGSVYALREGTGVDLLLGIGGTPEGIISACAVKCLGGTIQGKLWPKDDEERQRAIDAGHDLDRVLTTDDLVSGENVFFVATGITDGELLRGVRYRSETALTESIVMRSKSGTVRRIDSEHRLRKLRAYSAIDFDRAK
>CP033073.1|AYN39656.1|2915033_2915408_-|WhiB-family-transcriptional-regulator
MLQPPHSSLQVAAVPAQRLPARDRDQDAAWHTEAVCRRDEAGLFFAPSKEPTAARLSREDAAKRVCSRCPVMVECREHALLQPEPYGVWGGLTAAERRVVLARRRRREMDLKKASRPTANRIAG

Crispr_ID: CP033073_8

• CRISPR_ID: CP033073_8
• CRISPR_location: 3564641-3564785
• CRISPR_type: TypeI-E
• Repeat_type: NA
• Spacer_info: 2 spacers
• Cas_protein_info: cas3,cas6e,cas5,cas7,cse2gr11,cas8e

Consensus repeat of CP033073_8

Consensus_repeat	Method
ACCTCCGCGGGTGCGGAGCAGAC	CRISPRCasFinder

spacers of CP033073_8

>8.1|3564664|38|CP033073|CRISPRCasFinder
TCGTCGGCACGCGTCGGGTCGTAGTTGATCTGCGAGTA
>8.2|3564725|38|CP033073|CRISPRCasFinder
TTGAAGCACACCCCTCGGTAGAGGGTCGGCGTCGGGTG

CRISPR arrays and Neighbor proteins around CP033073_8

CRISPR arrays

The CRISPR arrays of CP033073_8

>merge|CP033073|8|3564641-3564785|CRISPRCasFinder
ACCTCCGCGAGTGCGGAGGAGACTCGTCGGCACGCGTCGGGTCGTAGTTGATCTGCGAGTAACCTCCGCACGTGCGGAGCAGACTTGAAGCACACCCCTCGGTAGAGGGTCGGCGTCGGGTGACCTCCGCAGGTGCGGAAGAGAC

>CP033073|8|8|3564641-3564785|CRISPRCasFinder
ACCTCCGCGAGTGCGGAGGAGAC	TCGTCGGCACGCGTCGGGTCGTAGTTGATCTGCGAGTA
ACCTCCGCACGTGCGGAGCAGAC	TTGAAGCACACCCCTCGGTAGAGGGTCGGCGTCGGGTG
ACCTCCGCAGGTGCGGAAGAGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	gnl|CDD|378191
CP033073.1|AYN40135.1|3555884_3557045_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173838
CP033073.1|AYN40142.1|3569324_3569588_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|226975
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	gnl|CDD|187860
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl|CDD|182031
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl|CDD|273842
CP033073.1|AYN40137.1|3557722_3558685_+|carbohydrate-kinase-family-protein	unknown	unknown	gnl|CDD|238917
CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator	unknown	unknown	gnl|CDD|225107
CP033073.1|AYN43681.1|3555289_3555892_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase	unknown	unknown	gnl|CDD|335313
CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
CP033073.1|AYN40133.1|3554161_3554428_+|acyl-carrier-protein	unknown	unknown	gnl|CDD|181065
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl|CDD|378153
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl|CDD|378050
CP033073.1|AYN40150.1|3577687_3579082_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40136.1|3557078_3557492_+|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl|CDD|234610
CP033073.1|AYN40134.1|3554438_3555284_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein	unknown	unknown	gnl|CDD|226951
CP033073.1|AYN40132.1|3552829_3554143_+|diaminopimelate-decarboxylase	unknown	unknown	gnl|CDD|143506

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	5e-42	139.1	0.0
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	1.6e-89	295.7	0.7
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	1.9e-45	150.2	0.0
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	3.4e-48	158.5	0.1
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	6.1e-21	70.0	0.6
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	7.3e-51	168.2	0.6

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl|CDD|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	9.77282e-15
CP033073.1|AYN40135.1|3555884_3557045_+|acyl-CoA-dehydrogenase	gnl|CDD|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	1.18245e-42
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	gnl|CDD|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	4.63158e-61
CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein	gnl|CDD|226975	COG4627, COG4627, Uncharacterized protein conserved in bacteria [Function unknown].	3.21824e-11
CP033073.1|AYN40137.1|3557722_3558685_+|carbohydrate-kinase-family-protein	gnl|CDD|238917	cd01942, ribokinase_group_A, Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.	1.21778e-68
CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.35406e-41
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl|CDD|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	2.87054e-47
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl|CDD|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	6.767e-40
CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase	gnl|CDD|335313	pfam03403, PAF-AH_p_II, Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	1.88882e-14
CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	8.24925e-15
CP033073.1|AYN40133.1|3554161_3554428_+|acyl-carrier-protein	gnl|CDD|181065	PRK07639, PRK07639, petrobactin biosynthesis protein AsbD.	4.4795e-10
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl|CDD|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	2.84796e-103
CP033073.1|AYN40136.1|3557078_3557492_+|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl|CDD|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	4.06386e-23
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl|CDD|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	1.32991e-42
CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.26096e-30
CP033073.1|AYN40132.1|3552829_3554143_+|diaminopimelate-decarboxylase	gnl|CDD|143506	cd06839, PLPDE_III_Btrk_like, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase. This subfamily is composed of Bacillus circulans BtrK decarboxylase and similar proteins. These proteins are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases, eukaryotic ornithine decarboxylases and diaminopimelate decarboxylases. BtrK is presumed to function as a PLP-dependent decarboxylase involved in the biosynthesis of the aminoglycoside antibiotic butirosin. Homodimer formation and the presence of the PLP cofactor may be required for catalytic activity.	2.5207e-165

Protein sequences

>CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein
MGTAAYGSVPALLLALHNSTGGAGYVVTVPELEPGGLLPAALLMAGLLATVLLRSARAPRRWVLPVVAAVTGELLEWTYWLTHSSAGYGPTLLNVLVGCVSVPVLAAFAGAALRWLASGRPARLAAADASRSARWALLLPAVVVMTGDLLGLDLWQSASPGTGIGPSVLGYLVGLALLAAVVGGLVRWPRAAADLATLGLVGIGVYDVAQSGFGQSLVVVQKFGSPRGPAPLLPVETAHHASVLGGIQGAVLLALGLWLLPLTVLPDARRLLGRGPDPALTRRVRELTETRADAVSSAAAELRRIERDLHDGAQGRLVTIGMNLRVAEEMIHSDPHEAAALVVEARVASAAALEELRGLIRGMHPPMLADRGLGEAVRALALDLPLPCDTEIDLPERLAAPLESACYFAVAEVVTNAVRHASAHGLQIRMTHTDGLLRIEVVDDGVGGADPARGTGLAGVERRLAAFDGILAVSSPPGGPTIVVMEVPCV
>CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator
MRVVVAEDLFLLREGLVRLLKARGFEIVAATDSAPGLLGALLEFRPDLAIVDIRLPPTHTDDGLRAALTARERIPGLPILLLSQYVEQIYAQELLADQAGGVGYLLKDRVFSDDQFVDVIRTVAAGGTVMDPEVVTKLLGRRSRGERETLSRLTERERQVLELMAEGRSNSAIANRLFISEKAVSKHSTSIFAKLELAPSDDDNRRVLAVLAYLMSAPREGRLPPGH
>CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase
MTITPFMTQEGMTRRRMLGAALAVGAAVPMGVARPVWAASTAPGPVQLTLPVPTGPYPVGTVPLHLVDASRPDPVAGPGHHRELMASLWYPARRAEDLPRAPWMAEGALRALLTDADFTLDPALGPLTAGRVGAPVHRTGQRLPVIVYSHGSGSHRGDHTIMVQELASHGYAVVTVDHTHDTFTQFPDGRVVTPGDVPMFPRDFAADLRFLLDCVERLAAGRNPDVDGKPLPQGLLGALDPRCIGAFGWSKGGTATALTMLADRRVRAGLSVDGPMQPTITADLDRPFMMMTAVFTRAAMPDVAEFWTHLRGWRLDIQADGAIHNSYGDNATLIPQAGKILGMTTQQIQDWIGTLDPARAVRIQQAYPLAFFDLNLRHRGQGHLLDGPCPAFPEVKFLP
>CP033073.1|AYN40137.1|3557722_3558685_+|carbohydrate-kinase-family-protein
MRITVTGSIATDHLMSYPGRFADQLVAGRLDRVSLSFLADTLEIRRGGVAANIAFGLGRLGLRPLLVGAAGADFTDHRERLERAGVDTGPVRVSASAHTARFVCTTDADQNQIATFYAGAMAEARDIDLAAVVRDARGVDLVVIAPDDPEAMLRHTDECQSLGIPFAADPSQQLARLDAGETRRLVDGARLLFTNEYEAALLQQRTGWSPAQILDRVGTWVTTLGPDGAAIARAGEPTLRVPAVATSRPLDPTGAGDAFRSGFLAGVAWGHTPERAARLGCTLATVILESVGTQEYELTAADLSARTDKAYAPAPAGRPS
>CP033073.1|AYN40136.1|3557078_3557492_+|4'-phosphopantetheinyl-transferase-superfamily-protein
MWIGVDVTHENELAALLARPWFRDYTYAPEELQTAASFGAERAHEFLTGRFAGKEAVLKVIGTGVGAGVTPRQVAILRAHGGAPQVRLSGAAARHARDRGIAGISVSVTHKKGVVVAVAIGVPAASHAGMEASEPSR
>CP033073.1|AYN40135.1|3555884_3557045_+|acyl-CoA-dehydrogenase
MTEPTGERIAALRSYVREAGRELRAIGLEIDRDPEAIDRWLGLPAVDIMRGCTIPAEYLDSPLRVGAYTYDMSSCLEHTVTIEELSYGDTGSMLACPGPLMSGVAVSALGDDKQRHHYYERMAGPEPVWTFFGLTEPAKGSAATELETTLVPEGDGFRLTGEKRYVGNAAYARLGVVFCRRAPGPLGIEAVLVDTQAPGFHAEPIPTVGMRGARISAIRLDGVRVEREHILGYDSLKPSRRGLIGAIRTLQRFRPVLAGTIVGLCRAVLDHVREQRPALAGGARARLEDLEDRLTAVRRQNYEVAAAIDAGRVRADRVAGVKTRAAELAERCTLAAADLMGPGALLEDPLLNKLYRDARAFEFMEGTGHIQRLAVFQGVLKRTFLN
>CP033073.1|AYN43681.1|3555289_3555892_+|hypothetical-protein
MDTATTTSPAAAGLRDFATALDACHDRAASGGLVVSRGGWAVASPARVTAGAQVPGSSGALMAERGGTPAGDRRQEAFADELIGLHRQTLREVLDGAVARLDRRVSEGANLLNRQLVQGAVADVALALSEADDLRELPMSTPWRRWRIHRDLVNAGRTALKLYGAGGFVAGGPGTVLYLTEVLGNTYLRPEQPGPEAGDD
>CP033073.1|AYN40134.1|3554438_3555284_+|hypothetical-protein
MPTLRAACAVVSPPRRPYDDDPSLLSYYRDLVEPFGLEVEEDLLRAGPNVGHRDLIDRLVTAGDIGDSAPDLVIVTQALPDVTPFTAISPYLDRLLGGRATNFGIHQQGLAAPFTALRIISAFQRAGRSLDAVLAVLEQTTLPTRFPLVHDNHLVDSGVMLRFGRDGGPRVTEVEAVPATEPVAARIGEVADKEPDGTLVVAGPWLDVATLDGVRHHYQAGRGTYCTSVWLALARHWRSWQQEYPTVVLCDTDPRSGDSHLAVLRSDGHGPLPGAAGGEGR
>CP033073.1|AYN40133.1|3554161_3554428_+|acyl-carrier-protein
MERDSVISAVEKSLSEVLERPVTGLTEEVRLFEDLHLDSTSVLELLMALEDAVDISVDPEDLDMDDFTSVGSLTDYVLSQAAQTTGEG
>CP033073.1|AYN40132.1|3552829_3554143_+|diaminopimelate-decarboxylase
MSSRKEAASSTNGTSGTEFHVQGVPISHIAEEFGTPVFVYDAEELRSVYQSLRDRLHPAVDVFFSLKANPNISITSRLGSLGAGAEISSMVELMTVTRAGIAPDDIIFLGPGKTRAELEACVAAGVYAIVCESLDEVAEIEEIAAATGRDEVPVLLRVNPDFHTKGSGLTMGGKPRQFGIDADILRRSRGLLDRLRRVRVRGFHAYMGTRFLGAEDLAHNTRQILALADELAQALGIELETVDFGGGFGVAYFDNEKDLDLRATVAGINEVVEPFAAAHPRCRLINELGRYLTATCGTYVVRARYVKESMGERFVVADGGTNHHMAAVGVGSFVKRNFPIRSLTRYDDEPTGTYTVTGPLCTPNDVIGKKVVLPPVQAGDLLGVERSGAYGPTASPGLFLGHGFPAEVLVHNGTAHLVRERDRKEELLTKQRLIDFD
>CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'
MIHDLFGSPVWPTQPATGPAAVVTTGLVILADWLVSQLPWIRDRQRRWDRDPTRDWHAHVRRARRAAPKTLREAQLVPPTWRRTRSFHNLFPHLHGKPLHPLQTSLAQSLRPLVANGPGLLLITAPPGEGKTESALFAERIMGPAAGTKSLAFLLPTMATTDAMWARVRAYARANCRTPPPVTLLHAMAWLDAEYTPDQLTTVTSSPDVVAEWLRGRHRGFLAGIAVGTWDQAALAVLPHRFMALRWLGLSGKTVIIDEVHAYDAHGHALTLRLLEWLGALGVPVVLLSATVTGDTAAALVHAYRRGAGHHDTPPINPSYPGWTYTDHATGTITTSPTLGSNRAHTLTVDTITCTHTHNPDHARGRARAILDLLTPLQQIGAGAALVICNTVADAQATRDLLDTAWASHTDRALVRILHARMPARQRAAITRRLQRWTGPHGKRPHQPFVVVTTQVAEQSLDVDFDLVISDLAPFALLLQRAGRGHRHPRSDRPVWAKTPRLAVLIPVGQLPPPAWGDVYPASVLRRTRDLLTTLNDQPINVPGDVQRLVDQVYGPEFAGADDTARLADDAQRTATAHLTAIGAPATVRDLHPLTNTAEHPDQITTRLGADSVRVLPTYLTPDGHHWLHPTHYTPRTALPDRINPEDRGTIRRLMQATIPINSQWLTGRDPTTHIPETWSNIPGLRDLILLPHYVTRTAIGPYRAAGKAISLDPQNGLVRR
>CP033073.1|AYN40142.1|3569324_3569588_+|hypothetical-protein
MAGWVGQTGLPKRSWIRWDEVFALFVPCLLPQAGCGGERAGEFVSLVGEGERVGAVVAAEQLAYLVGGVAGGAAGERQAVLAVQEFR
>CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MTTSTASTQTVHLARLHLQARSRDVHRDLKDASRLHTTIQALFPDALGAAPRTATNTLYRIEREQTGAQLLIQSTLPINRNALPSGYTSQVEYRDLTPLLNWVAGGRVVRFRIDGNPIKSVPVPGGGRGRRVPVSGEEALAWWERQAARAGLTNELVLDLPQPDVLGSRSEAKRIRLRAIRFEGVATVTDPEALRAAIITGIGQGRAYGLGLLSIAPYRT
>CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MSGGLLLHLSGPLQSWGSDADFEVRTTHRWPTRSGLAGLLACCLGRPRDTDNTDLAELSYTIRVDRPGQREMDFHTVGGGYPRHLTPPTADGKFRKLGEGTILTQRWYLTDAAFTIAVTGPAPTLARCAEALQRPRFAPYLGRRSCVPDTPILILDAVTDPVAELDRVPLHRTPARFGHRDPVTFLYDTAPEPGAPPDTEIRDQPGPRRRFADRPVWERQRQLPDAEDAGRGTDWLTALLAYREAAAA
>CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MTNFGPGSLYVDVHLIQSYPYSNLNRDRQGAPKTAKYGGAMRARHSSQNGKRHNRTAVEKAIGVRAVRTRGVPHAVAKRLTARGWQPELALAAGQMLILAAGVKGLGIADSGGTNALLFLPESALDELAELADGHRGDITQAVYDIEAEQAKAAKKSTRKKADADLEPAADDEEEPAVGEGSALARYATKILPKAAVLTILQSRNASVAAFGRMLANEAGSIVDGAVQMAHGLSTHAASTQLDYFTAVDDILDEEGTERGAGHMGDQRYTSATFYRYTSMNVTELVSNLDGDTQTAQAVLAEFVRAFVTTVLPAKASGTAPFTVPHLTYIALRSDRPVSLVGAYETPVPDSIEGYLPRSMQRLNDHARAHHRFLGTAGLITHAHSGLTDDAFDALGDRLDGLDELIARVSDTVAKGLA
>CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MRTVRTACATPGGRAALRNGLAEELTSPWQLYMHLLPAGGIPAYAPNREAEFPYLLVACLYAVHDAPNPRTAKTNPPSAVKPAEMWQNLGWSYALAARVGAMRRENAADALSHLAELGSDDLHRELPGAISLLRSQQIPVKWPVLLRDLTRWPKWADDVRIEWARAFHVPTNRTAEETAQ
>CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MLRAFNVAEQPCITAVFRRDADSKELASLVPGAEPGGRREVGLRKVLAAAHLVADVEVTNPAVESMLRRLLTALAVRAGGLDVPDLDAWEDRFDALLVAGRFDADAVHAYFDKWRHRFDLYDGQWPFLQDPRLATECSRQAPPGKLVMPRPSGSNQPWLDRTPQQVPVPSGEALGWLLAWRGYGPSGTGAQRQHGGVNSKNMKAGPLRSLVSFHPLGESLFTSLVLSCPPPAGGEDPAQDLAPWEREEPEDPLLPSPARGPVSLLIGRTAHHVLLSPDETGAEASGCWVAWGTRADLPPARDPFVIDRAKGGPVRASWRRSLLRDFDAFIHAKDPAAAGTKGQILPAWLSVFADLPEEVLDGLGSVRVRALGCHQEKQEKDEHWYAVTTPASIAAFLPLGTHNGPLAWPTPAKRRRVRRPTWPRRCALRGNTWRPARRHAHGLMRPPQRTGTGPSRCSGRRSTGMTQRRRGSAASPWRSTTPPPGRPRPPRKGCTRWPRPVPRSLIPGFLEGGQRPRDHRVPAHPIAEEEPAGAVRTVHAHRSHCMRHTGRPGRLA
>CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein
MNQVPPSISELTLAATPNAVAWARRHTVDVLQRWRFPAEGIEVARLLVSELATNAILHARRAESSGSSGTGSAGPGVITLRLWPTEHGVVLLVGDADPRPPVLRAGGLGATGGRGLLLTQTMASCWGYYHPGHHPGKIVWAHVPTRPNASLNEPGGASGQLAPPLLIGRILTGLREL
>CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein
MSPSGMPSVDLLGEQIASVLADPATSHGLARALRAAAKEIELHRYHHASRRAWPNGRIDDKPAKVQIGGGAHRIDGFFNIDLVPPADLLWDIREGVPLQDASTDEIFSEHFLEHIDYPRSAKHYVREAHRVLVPGGRIITGVPDAAFALNQYPGPLDASDEMIERWYAKRDCRGHINTCLDLINLVFRDQDDDPTYTPHLWAYDHEKLIQLFTEAGFTTVEPWTFDPAMANPKRRWGSVYVVATK
>CP033073.1|AYN40150.1|3577687_3579082_-|hypothetical-protein
MDFLDAYHLWADAHAFFDSTLIPSPADHTDPLATQAAGWNRRLAEDTPNGHLLRRNALFEALSGNGKLHLLHVTHALEEISQQGVLYPSGGCLVGSIYCAPLTATDRGFRMHNLGAYVLTKEAPTFLAKLGVTDRVPTPLIFEIDTPPQAYRGLAGVDYLRLGLIHLQIYSHLEYLLSKSERHQLRESVVSRVKNSAAFLATAAAVAYQGTRVDAEPFLKLLDETIPRLPILGYLYFEAVAEYLMLHSASHHTRRLAELGELNNWLYKEMLFASFPAMAGKFDLARFRPRPKQLAALIHRVDPTIDTSHASAYLVERISYLVAARLFAPGDAPEAWHHTRWEFDSLATQLGPLLGHLIHRELRTFGRYPDFYFYFDQHKALQAWNYWNHMDIVAPFNGTMPKGEIGINPAYPNLDYRAWRAEQDDAGHLHPAEELSLTIAPRLVDIKYTLMRNNQWTAPAPSAA

Crispr_ID: CP033073_7

• CRISPR_ID: CP033073_7
• CRISPR_location: 3563908-3564544
• CRISPR_type: TypeI-E
• Repeat_type: NA
• Spacer_info: 10 spacers
• Cas_protein_info: cas3,cas6e,cas5,cas7,cse2gr11,cas8e

Consensus repeat of CP033073_7

Consensus_repeat	Method
ACCTCCGCGGGTGCGGAGCAGAC	CRISPRCasFinder

spacers of CP033073_7

>7.1|3563931|41|CP033073|CRISPRCasFinder
CAGAAGCAAATCACCCTGGCGCATGAAGGCTGGGACGGGTG
>7.2|3563995|38|CP033073|CRISPRCasFinder
CCGTGGATCCCGACCATGGACGACCTCGCCGATGGGTG
>7.3|3564056|38|CP033073|CRISPRCasFinder
GTGGCGAGCTCGCAGAAGAACCGGTCCGGCGCCGGAGG
>7.4|3564117|38|CP033073|CRISPRCasFinder
GCCATGCGCTTCTCTGGCGAGTACATCTACGTCGGGTG
>7.5|3564178|38|CP033073|CRISPRCasFinder
ACAACGTTGAACCAGATACCGGAACGCTCACCCGGATG
>7.6|3564239|38|CP033073|CRISPRCasFinder
AGCGTCCTCGATTTCGACCGCGCGCCTCTCGGAGAGTG
>7.7|3564300|38|CP033073|CRISPRCasFinder
TGGCCGTGTGCGGCGACGTGTGTGGGACGGACCGGGTG
>7.8|3564361|38|CP033073|CRISPRCasFinder
TCTCCAGGGCCGGGCAGCACCGTGGCCGCGACCGCGTG
>7.9|3564422|38|CP033073|CRISPRCasFinder
AACGAGCTAGTCGCCACGATCGCCTGGTCCGGCGGGTA
>7.10|3564483|38|CP033073|CRISPRCasFinder
GTCTGGGGTTCGGCCCGCAACCAGGTCGACGGCGGGCG

CRISPR arrays and Neighbor proteins around CP033073_7

CRISPR arrays

The CRISPR arrays of CP033073_7

>merge|CP033073|7|3563908-3564544|CRISPRCasFinder
ACCTCCGTGGGTGCGGAGCAAGCCAGAAGCAAATCACCCTGGCGCATGAAGGCTGGGACGGGTGACCTCCGCAGGCGCGGAGCGGACCCGTGGATCCCGACCATGGACGACCTCGCCGATGGGTGACCTCCGCGGATGCGGAACAGACGTGGCGAGCTCGCAGAAGAACCGGTCCGGCGCCGGAGGAGCTCCGCAGGCGCGGAGCGAACGCCATGCGCTTCTCTGGCGAGTACATCTACGTCGGGTGACCTCCGCGGGAGCAGAGCAGACACAACGTTGAACCAGATACCGGAACGCTCACCCGGATGACCTTCGTGGGTACGGAGCAGTCAGCGTCCTCGATTTCGACCGCGCGCCTCTCGGAGAGTGACCTCCGCAGATTCGGAGCAGAATGGCCGTGTGCGGCGACGTGTGTGGGACGGACCGGGTGACCTCCACAGGCGCAAAGCAGACTCTCCAGGGCCGGGCAGCACCGTGGCCGCGACCGCGTGACCTCCGCGGGTGCGGAGCAGACAACGAGCTAGTCGCCACGATCGCCTGGTCCGGCGGGTAACCTCCGCGGGTGCGGAGCGGACGTCTGGGGTTCGGCCCGCAACCAGGTCGACGGCGGGCGACCTCCGCCGGGGCGGAGCATAGG

>CP033073|7|7|3563908-3564544|CRISPRCasFinder
ACCTCCGTGGGTGCGGAGCAAGC	CAGAAGCAAATCACCCTGGCGCATGAAGGCTGGGACGGGTG
ACCTCCGCAGGCGCGGAGCGGAC	CCGTGGATCCCGACCATGGACGACCTCGCCGATGGGTG
ACCTCCGCGGATGCGGAACAGAC	GTGGCGAGCTCGCAGAAGAACCGGTCCGGCGCCGGAGG
AGCTCCGCAGGCGCGGAGCGAAC	GCCATGCGCTTCTCTGGCGAGTACATCTACGTCGGGTG
ACCTCCGCGGGAGCAGAGCAGAC	ACAACGTTGAACCAGATACCGGAACGCTCACCCGGATG
ACCTTCGTGGGTACGGAGCAGTC	AGCGTCCTCGATTTCGACCGCGCGCCTCTCGGAGAGTG
ACCTCCGCAGATTCGGAGCAGAA	TGGCCGTGTGCGGCGACGTGTGTGGGACGGACCGGGTG
ACCTCCACAGGCGCAAAGCAGAC	TCTCCAGGGCCGGGCAGCACCGTGGCCGCGACCGCGTG
ACCTCCGCGGGTGCGGAGCAGAC	AACGAGCTAGTCGCCACGATCGCCTGGTCCGGCGGGTA
ACCTCCGCGGGTGCGGAGCGGAC	GTCTGGGGTTCGGCCCGCAACCAGGTCGACGGCGGGCG
ACCTCCGCCGGGGCGGAGCATAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	gnl|CDD|378191
CP033073.1|AYN40135.1|3555884_3557045_+|acyl-CoA-dehydrogenase	unknown	unknown	gnl|CDD|173838
CP033073.1|AYN40142.1|3569324_3569588_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|226975
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	gnl|CDD|187860
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl|CDD|182031
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl|CDD|273842
CP033073.1|AYN40137.1|3557722_3558685_+|carbohydrate-kinase-family-protein	unknown	unknown	gnl|CDD|238917
CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator	unknown	unknown	gnl|CDD|225107
CP033073.1|AYN43681.1|3555289_3555892_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase	unknown	unknown	gnl|CDD|335313
CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
CP033073.1|AYN40133.1|3554161_3554428_+|acyl-carrier-protein	unknown	unknown	gnl|CDD|181065
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl|CDD|378153
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl|CDD|378050
CP033073.1|AYN40150.1|3577687_3579082_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40136.1|3557078_3557492_+|4'-phosphopantetheinyl-transferase-superfamily-protein	unknown	unknown	gnl|CDD|234610
CP033073.1|AYN40134.1|3554438_3555284_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein	unknown	unknown	gnl|CDD|226951
CP033073.1|AYN40132.1|3552829_3554143_+|diaminopimelate-decarboxylase	unknown	unknown	gnl|CDD|143506

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	5e-42	139.1	0.0
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	1.6e-89	295.7	0.7
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	1.9e-45	150.2	0.0
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	3.4e-48	158.5	0.1
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	6.1e-21	70.0	0.6
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	7.3e-51	168.2	0.6

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl|CDD|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	9.77282e-15
CP033073.1|AYN40135.1|3555884_3557045_+|acyl-CoA-dehydrogenase	gnl|CDD|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	1.18245e-42
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	gnl|CDD|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	4.63158e-61
CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein	gnl|CDD|226975	COG4627, COG4627, Uncharacterized protein conserved in bacteria [Function unknown].	3.21824e-11
CP033073.1|AYN40137.1|3557722_3558685_+|carbohydrate-kinase-family-protein	gnl|CDD|238917	cd01942, ribokinase_group_A, Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time.	1.21778e-68
CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.35406e-41
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl|CDD|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	2.87054e-47
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl|CDD|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	6.767e-40
CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase	gnl|CDD|335313	pfam03403, PAF-AH_p_II, Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	1.88882e-14
CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	8.24925e-15
CP033073.1|AYN40133.1|3554161_3554428_+|acyl-carrier-protein	gnl|CDD|181065	PRK07639, PRK07639, petrobactin biosynthesis protein AsbD.	4.4795e-10
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl|CDD|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	2.84796e-103
CP033073.1|AYN40136.1|3557078_3557492_+|4'-phosphopantetheinyl-transferase-superfamily-protein	gnl|CDD|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	4.06386e-23
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl|CDD|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	1.32991e-42
CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.26096e-30
CP033073.1|AYN40132.1|3552829_3554143_+|diaminopimelate-decarboxylase	gnl|CDD|143506	cd06839, PLPDE_III_Btrk_like, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase. This subfamily is composed of Bacillus circulans BtrK decarboxylase and similar proteins. These proteins are fold type III PLP-dependent enzymes that contain an N-terminal PLP-binding TIM-barrel domain and a C-terminal beta-sandwich domain, similar to bacterial alanine racemases, eukaryotic ornithine decarboxylases and diaminopimelate decarboxylases. BtrK is presumed to function as a PLP-dependent decarboxylase involved in the biosynthesis of the aminoglycoside antibiotic butirosin. Homodimer formation and the presence of the PLP cofactor may be required for catalytic activity.	2.5207e-165

Protein sequences

>CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein
MGTAAYGSVPALLLALHNSTGGAGYVVTVPELEPGGLLPAALLMAGLLATVLLRSARAPRRWVLPVVAAVTGELLEWTYWLTHSSAGYGPTLLNVLVGCVSVPVLAAFAGAALRWLASGRPARLAAADASRSARWALLLPAVVVMTGDLLGLDLWQSASPGTGIGPSVLGYLVGLALLAAVVGGLVRWPRAAADLATLGLVGIGVYDVAQSGFGQSLVVVQKFGSPRGPAPLLPVETAHHASVLGGIQGAVLLALGLWLLPLTVLPDARRLLGRGPDPALTRRVRELTETRADAVSSAAAELRRIERDLHDGAQGRLVTIGMNLRVAEEMIHSDPHEAAALVVEARVASAAALEELRGLIRGMHPPMLADRGLGEAVRALALDLPLPCDTEIDLPERLAAPLESACYFAVAEVVTNAVRHASAHGLQIRMTHTDGLLRIEVVDDGVGGADPARGTGLAGVERRLAAFDGILAVSSPPGGPTIVVMEVPCV
>CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator
MRVVVAEDLFLLREGLVRLLKARGFEIVAATDSAPGLLGALLEFRPDLAIVDIRLPPTHTDDGLRAALTARERIPGLPILLLSQYVEQIYAQELLADQAGGVGYLLKDRVFSDDQFVDVIRTVAAGGTVMDPEVVTKLLGRRSRGERETLSRLTERERQVLELMAEGRSNSAIANRLFISEKAVSKHSTSIFAKLELAPSDDDNRRVLAVLAYLMSAPREGRLPPGH
>CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase
MTITPFMTQEGMTRRRMLGAALAVGAAVPMGVARPVWAASTAPGPVQLTLPVPTGPYPVGTVPLHLVDASRPDPVAGPGHHRELMASLWYPARRAEDLPRAPWMAEGALRALLTDADFTLDPALGPLTAGRVGAPVHRTGQRLPVIVYSHGSGSHRGDHTIMVQELASHGYAVVTVDHTHDTFTQFPDGRVVTPGDVPMFPRDFAADLRFLLDCVERLAAGRNPDVDGKPLPQGLLGALDPRCIGAFGWSKGGTATALTMLADRRVRAGLSVDGPMQPTITADLDRPFMMMTAVFTRAAMPDVAEFWTHLRGWRLDIQADGAIHNSYGDNATLIPQAGKILGMTTQQIQDWIGTLDPARAVRIQQAYPLAFFDLNLRHRGQGHLLDGPCPAFPEVKFLP
>CP033073.1|AYN40137.1|3557722_3558685_+|carbohydrate-kinase-family-protein
MRITVTGSIATDHLMSYPGRFADQLVAGRLDRVSLSFLADTLEIRRGGVAANIAFGLGRLGLRPLLVGAAGADFTDHRERLERAGVDTGPVRVSASAHTARFVCTTDADQNQIATFYAGAMAEARDIDLAAVVRDARGVDLVVIAPDDPEAMLRHTDECQSLGIPFAADPSQQLARLDAGETRRLVDGARLLFTNEYEAALLQQRTGWSPAQILDRVGTWVTTLGPDGAAIARAGEPTLRVPAVATSRPLDPTGAGDAFRSGFLAGVAWGHTPERAARLGCTLATVILESVGTQEYELTAADLSARTDKAYAPAPAGRPS
>CP033073.1|AYN40136.1|3557078_3557492_+|4'-phosphopantetheinyl-transferase-superfamily-protein
MWIGVDVTHENELAALLARPWFRDYTYAPEELQTAASFGAERAHEFLTGRFAGKEAVLKVIGTGVGAGVTPRQVAILRAHGGAPQVRLSGAAARHARDRGIAGISVSVTHKKGVVVAVAIGVPAASHAGMEASEPSR
>CP033073.1|AYN40135.1|3555884_3557045_+|acyl-CoA-dehydrogenase
MTEPTGERIAALRSYVREAGRELRAIGLEIDRDPEAIDRWLGLPAVDIMRGCTIPAEYLDSPLRVGAYTYDMSSCLEHTVTIEELSYGDTGSMLACPGPLMSGVAVSALGDDKQRHHYYERMAGPEPVWTFFGLTEPAKGSAATELETTLVPEGDGFRLTGEKRYVGNAAYARLGVVFCRRAPGPLGIEAVLVDTQAPGFHAEPIPTVGMRGARISAIRLDGVRVEREHILGYDSLKPSRRGLIGAIRTLQRFRPVLAGTIVGLCRAVLDHVREQRPALAGGARARLEDLEDRLTAVRRQNYEVAAAIDAGRVRADRVAGVKTRAAELAERCTLAAADLMGPGALLEDPLLNKLYRDARAFEFMEGTGHIQRLAVFQGVLKRTFLN
>CP033073.1|AYN43681.1|3555289_3555892_+|hypothetical-protein
MDTATTTSPAAAGLRDFATALDACHDRAASGGLVVSRGGWAVASPARVTAGAQVPGSSGALMAERGGTPAGDRRQEAFADELIGLHRQTLREVLDGAVARLDRRVSEGANLLNRQLVQGAVADVALALSEADDLRELPMSTPWRRWRIHRDLVNAGRTALKLYGAGGFVAGGPGTVLYLTEVLGNTYLRPEQPGPEAGDD
>CP033073.1|AYN40134.1|3554438_3555284_+|hypothetical-protein
MPTLRAACAVVSPPRRPYDDDPSLLSYYRDLVEPFGLEVEEDLLRAGPNVGHRDLIDRLVTAGDIGDSAPDLVIVTQALPDVTPFTAISPYLDRLLGGRATNFGIHQQGLAAPFTALRIISAFQRAGRSLDAVLAVLEQTTLPTRFPLVHDNHLVDSGVMLRFGRDGGPRVTEVEAVPATEPVAARIGEVADKEPDGTLVVAGPWLDVATLDGVRHHYQAGRGTYCTSVWLALARHWRSWQQEYPTVVLCDTDPRSGDSHLAVLRSDGHGPLPGAAGGEGR
>CP033073.1|AYN40133.1|3554161_3554428_+|acyl-carrier-protein
MERDSVISAVEKSLSEVLERPVTGLTEEVRLFEDLHLDSTSVLELLMALEDAVDISVDPEDLDMDDFTSVGSLTDYVLSQAAQTTGEG
>CP033073.1|AYN40132.1|3552829_3554143_+|diaminopimelate-decarboxylase
MSSRKEAASSTNGTSGTEFHVQGVPISHIAEEFGTPVFVYDAEELRSVYQSLRDRLHPAVDVFFSLKANPNISITSRLGSLGAGAEISSMVELMTVTRAGIAPDDIIFLGPGKTRAELEACVAAGVYAIVCESLDEVAEIEEIAAATGRDEVPVLLRVNPDFHTKGSGLTMGGKPRQFGIDADILRRSRGLLDRLRRVRVRGFHAYMGTRFLGAEDLAHNTRQILALADELAQALGIELETVDFGGGFGVAYFDNEKDLDLRATVAGINEVVEPFAAAHPRCRLINELGRYLTATCGTYVVRARYVKESMGERFVVADGGTNHHMAAVGVGSFVKRNFPIRSLTRYDDEPTGTYTVTGPLCTPNDVIGKKVVLPPVQAGDLLGVERSGAYGPTASPGLFLGHGFPAEVLVHNGTAHLVRERDRKEELLTKQRLIDFD
>CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'
MIHDLFGSPVWPTQPATGPAAVVTTGLVILADWLVSQLPWIRDRQRRWDRDPTRDWHAHVRRARRAAPKTLREAQLVPPTWRRTRSFHNLFPHLHGKPLHPLQTSLAQSLRPLVANGPGLLLITAPPGEGKTESALFAERIMGPAAGTKSLAFLLPTMATTDAMWARVRAYARANCRTPPPVTLLHAMAWLDAEYTPDQLTTVTSSPDVVAEWLRGRHRGFLAGIAVGTWDQAALAVLPHRFMALRWLGLSGKTVIIDEVHAYDAHGHALTLRLLEWLGALGVPVVLLSATVTGDTAAALVHAYRRGAGHHDTPPINPSYPGWTYTDHATGTITTSPTLGSNRAHTLTVDTITCTHTHNPDHARGRARAILDLLTPLQQIGAGAALVICNTVADAQATRDLLDTAWASHTDRALVRILHARMPARQRAAITRRLQRWTGPHGKRPHQPFVVVTTQVAEQSLDVDFDLVISDLAPFALLLQRAGRGHRHPRSDRPVWAKTPRLAVLIPVGQLPPPAWGDVYPASVLRRTRDLLTTLNDQPINVPGDVQRLVDQVYGPEFAGADDTARLADDAQRTATAHLTAIGAPATVRDLHPLTNTAEHPDQITTRLGADSVRVLPTYLTPDGHHWLHPTHYTPRTALPDRINPEDRGTIRRLMQATIPINSQWLTGRDPTTHIPETWSNIPGLRDLILLPHYVTRTAIGPYRAAGKAISLDPQNGLVRR
>CP033073.1|AYN40142.1|3569324_3569588_+|hypothetical-protein
MAGWVGQTGLPKRSWIRWDEVFALFVPCLLPQAGCGGERAGEFVSLVGEGERVGAVVAAEQLAYLVGGVAGGAAGERQAVLAVQEFR
>CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MTTSTASTQTVHLARLHLQARSRDVHRDLKDASRLHTTIQALFPDALGAAPRTATNTLYRIEREQTGAQLLIQSTLPINRNALPSGYTSQVEYRDLTPLLNWVAGGRVVRFRIDGNPIKSVPVPGGGRGRRVPVSGEEALAWWERQAARAGLTNELVLDLPQPDVLGSRSEAKRIRLRAIRFEGVATVTDPEALRAAIITGIGQGRAYGLGLLSIAPYRT
>CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MSGGLLLHLSGPLQSWGSDADFEVRTTHRWPTRSGLAGLLACCLGRPRDTDNTDLAELSYTIRVDRPGQREMDFHTVGGGYPRHLTPPTADGKFRKLGEGTILTQRWYLTDAAFTIAVTGPAPTLARCAEALQRPRFAPYLGRRSCVPDTPILILDAVTDPVAELDRVPLHRTPARFGHRDPVTFLYDTAPEPGAPPDTEIRDQPGPRRRFADRPVWERQRQLPDAEDAGRGTDWLTALLAYREAAAA
>CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MTNFGPGSLYVDVHLIQSYPYSNLNRDRQGAPKTAKYGGAMRARHSSQNGKRHNRTAVEKAIGVRAVRTRGVPHAVAKRLTARGWQPELALAAGQMLILAAGVKGLGIADSGGTNALLFLPESALDELAELADGHRGDITQAVYDIEAEQAKAAKKSTRKKADADLEPAADDEEEPAVGEGSALARYATKILPKAAVLTILQSRNASVAAFGRMLANEAGSIVDGAVQMAHGLSTHAASTQLDYFTAVDDILDEEGTERGAGHMGDQRYTSATFYRYTSMNVTELVSNLDGDTQTAQAVLAEFVRAFVTTVLPAKASGTAPFTVPHLTYIALRSDRPVSLVGAYETPVPDSIEGYLPRSMQRLNDHARAHHRFLGTAGLITHAHSGLTDDAFDALGDRLDGLDELIARVSDTVAKGLA
>CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MRTVRTACATPGGRAALRNGLAEELTSPWQLYMHLLPAGGIPAYAPNREAEFPYLLVACLYAVHDAPNPRTAKTNPPSAVKPAEMWQNLGWSYALAARVGAMRRENAADALSHLAELGSDDLHRELPGAISLLRSQQIPVKWPVLLRDLTRWPKWADDVRIEWARAFHVPTNRTAEETAQ
>CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MLRAFNVAEQPCITAVFRRDADSKELASLVPGAEPGGRREVGLRKVLAAAHLVADVEVTNPAVESMLRRLLTALAVRAGGLDVPDLDAWEDRFDALLVAGRFDADAVHAYFDKWRHRFDLYDGQWPFLQDPRLATECSRQAPPGKLVMPRPSGSNQPWLDRTPQQVPVPSGEALGWLLAWRGYGPSGTGAQRQHGGVNSKNMKAGPLRSLVSFHPLGESLFTSLVLSCPPPAGGEDPAQDLAPWEREEPEDPLLPSPARGPVSLLIGRTAHHVLLSPDETGAEASGCWVAWGTRADLPPARDPFVIDRAKGGPVRASWRRSLLRDFDAFIHAKDPAAAGTKGQILPAWLSVFADLPEEVLDGLGSVRVRALGCHQEKQEKDEHWYAVTTPASIAAFLPLGTHNGPLAWPTPAKRRRVRRPTWPRRCALRGNTWRPARRHAHGLMRPPQRTGTGPSRCSGRRSTGMTQRRRGSAASPWRSTTPPPGRPRPPRKGCTRWPRPVPRSLIPGFLEGGQRPRDHRVPAHPIAEEEPAGAVRTVHAHRSHCMRHTGRPGRLA
>CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein
MNQVPPSISELTLAATPNAVAWARRHTVDVLQRWRFPAEGIEVARLLVSELATNAILHARRAESSGSSGTGSAGPGVITLRLWPTEHGVVLLVGDADPRPPVLRAGGLGATGGRGLLLTQTMASCWGYYHPGHHPGKIVWAHVPTRPNASLNEPGGASGQLAPPLLIGRILTGLREL
>CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein
MSPSGMPSVDLLGEQIASVLADPATSHGLARALRAAAKEIELHRYHHASRRAWPNGRIDDKPAKVQIGGGAHRIDGFFNIDLVPPADLLWDIREGVPLQDASTDEIFSEHFLEHIDYPRSAKHYVREAHRVLVPGGRIITGVPDAAFALNQYPGPLDASDEMIERWYAKRDCRGHINTCLDLINLVFRDQDDDPTYTPHLWAYDHEKLIQLFTEAGFTTVEPWTFDPAMANPKRRWGSVYVVATK
>CP033073.1|AYN40150.1|3577687_3579082_-|hypothetical-protein
MDFLDAYHLWADAHAFFDSTLIPSPADHTDPLATQAAGWNRRLAEDTPNGHLLRRNALFEALSGNGKLHLLHVTHALEEISQQGVLYPSGGCLVGSIYCAPLTATDRGFRMHNLGAYVLTKEAPTFLAKLGVTDRVPTPLIFEIDTPPQAYRGLAGVDYLRLGLIHLQIYSHLEYLLSKSERHQLRESVVSRVKNSAAFLATAAAVAYQGTRVDAEPFLKLLDETIPRLPILGYLYFEAVAEYLMLHSASHHTRRLAELGELNNWLYKEMLFASFPAMAGKFDLARFRPRPKQLAALIHRVDPTIDTSHASAYLVERISYLVAARLFAPGDAPEAWHHTRWEFDSLATQLGPLLGHLIHRELRTFGRYPDFYFYFDQHKALQAWNYWNHMDIVAPFNGTMPKGEIGINPAYPNLDYRAWRAEQDDAGHLHPAEELSLTIAPRLVDIKYTLMRNNQWTAPAPSAA

Crispr_ID: CP033073_10

• CRISPR_ID: CP033073_10
• CRISPR_location: 3575832-3576043
• CRISPR_type: TypeI-E
• Repeat_type: NA
• Spacer_info: 3 spacers
• Cas_protein_info: cas8e,cse2gr11,cas7,cas5,cas6e,cas3

Consensus repeat of CP033073_10

Consensus_repeat	Method
GTTCGCTCCGCACCCGCGGAGGTCACCCGT	CRISPRCasFinder

spacers of CP033073_10

>10.1|3575862|31|CP033073|CRISPRCasFinder
GCGTCGTCGACCTAGCAGGCGGTACGCGCAC
>10.2|3575923|31|CP033073|CRISPRCasFinder
ACTTCCGAGGTCGCTCGTCATGGTTGCCGTC
>10.3|3575984|30|CP033073|CRISPRCasFinder
TCCGCCGGCGGGCTCCACGGTGGTCTGCGG

CRISPR arrays and Neighbor proteins around CP033073_10

CRISPR arrays

The CRISPR arrays of CP033073_10

>merge|CP033073|10|3575832-3576043|CRISPRCasFinder
CTCCGCTCCGCGACCACCGAGGTACCCCGAGCGTCGTCGACCTAGCAGGCGGTACGCGCACCTTCGCTCCGCGCCCGCGGAGGTAGCCCGTACTTCCGAGGTCGCTCGTCATGGTTGCCGTCGTTCGCTCCGCACCCGCGAGGTATCCCCGGTCCGCCGGCGGGCTCCACGGTGGTCTGCGGGTTCGCTTCGCAATCGCGGAGGTAACCCGG

>CP033073|10|10|3575832-3576043|CRISPRCasFinder
CTCCGCTCCGCGACCACCGAGGTACCCCGA	GCGTCGTCGACCTAGCAGGCGGTACGCGCAC
CTTCGCTCCGCGCCCGCGGAGGTAGCCCGT	ACTTCCGAGGTCGCTCGTCATGGTTGCCGTC
GTTCGCTCCGCACCCGCGAGGTATCCCCGG	TCCGCCGGCGGGCTCCACGGTGGTCTGCGG
GTTCGCTTCGCAATCGCGGAGGTAACCCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
CP033073.1|AYN40142.1|3569324_3569588_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40157.1|3583103_3583592_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|226975
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl|CDD|182031
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	gnl|CDD|378191
CP033073.1|AYN40153.1|3580633_3580933_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40156.1|3582587_3583001_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239217
CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator	unknown	unknown	gnl|CDD|225107
CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase	unknown	unknown	gnl|CDD|335313
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl|CDD|378050
CP033073.1|AYN40154.1|3581013_3581523_-|nucleoside-diphosphate-kinase	unknown	unknown	gnl|CDD|239876
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl|CDD|378153
CP033073.1|AYN40155.1|3581931_3582591_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239217
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl|CDD|273842
CP033073.1|AYN40150.1|3577687_3579082_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40151.1|3579084_3579849_-|hypothetical-protein	unknown	unknown	gnl|CDD|235947
CP033073.1|AYN40152.1|3579888_3580473_-|hypothetical-protein	unknown	unknown	gnl|CDD|143628
CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein	unknown	unknown	gnl|CDD|226951
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	gnl|CDD|187860

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	5e-42	139.1	0.0
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	1.6e-89	295.7	0.7
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	1.9e-45	150.2	0.0
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	6.1e-21	70.0	0.6
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	3.4e-48	158.5	0.1
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	7.3e-51	168.2	0.6

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	8.24925e-15
CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein	gnl|CDD|226975	COG4627, COG4627, Uncharacterized protein conserved in bacteria [Function unknown].	3.21824e-11
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	gnl|CDD|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	4.63158e-61
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl|CDD|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	9.77282e-15
CP033073.1|AYN40156.1|3582587_3583001_+|NUDIX-hydrolase	gnl|CDD|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	1.77975e-22
CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.35406e-41
CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase	gnl|CDD|335313	pfam03403, PAF-AH_p_II, Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	1.88882e-14
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl|CDD|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	2.87054e-47
CP033073.1|AYN40154.1|3581013_3581523_-|nucleoside-diphosphate-kinase	gnl|CDD|239876	cd04413, NDPk_I, Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.	1.40311e-50
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl|CDD|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	2.84796e-103
CP033073.1|AYN40155.1|3581931_3582591_+|NUDIX-hydrolase	gnl|CDD|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	2.96975e-14
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl|CDD|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	6.767e-40
CP033073.1|AYN40151.1|3579084_3579849_-|hypothetical-protein	gnl|CDD|235947	PRK07152, nadD, nicotinate-nucleotide adenylyltransferase.	2.04404e-05
CP033073.1|AYN40152.1|3579888_3580473_-|hypothetical-protein	gnl|CDD|143628	cd07890, CYTH-like_AC_IV-like, Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily. This subgroup contains class IV ACs and similar proteins. AC catalyzes the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. cAMP is a key signaling molecule which conveys a variety of signals in different cell types. In prokaryotes, cAMP is a catabolite derepression signal which triggers the expression of metabolic pathways including the lactose operon. Six non-homologous classes of ACs have been identified (I-VI). Class IV ACs are found in this group. In bacteria, the gene encoding Class IV AC has been designated cyaB and the protein as AC2. AC-IV occurs in addition to AC-I in bacterial pathogens such as Yersinia pestis (plague disease). The role of AC-IV is unknown but it has been speculated that it may be a factor in pathogenesis, perhaps providing cAMP for a secondary internal signaling function, or for secretion and uptake into host cells, where it may disrupt normal cellular processes. This subgroup belongs to the CYTH/triphosphate tunnel metalloenzyme (TTM)-like superfamily, whose enzymes have a unique active site located within an eight-stranded beta barrel.	4.13397e-05
CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.26096e-30
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl|CDD|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	1.32991e-42

Protein sequences

>CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MLRAFNVAEQPCITAVFRRDADSKELASLVPGAEPGGRREVGLRKVLAAAHLVADVEVTNPAVESMLRRLLTALAVRAGGLDVPDLDAWEDRFDALLVAGRFDADAVHAYFDKWRHRFDLYDGQWPFLQDPRLATECSRQAPPGKLVMPRPSGSNQPWLDRTPQQVPVPSGEALGWLLAWRGYGPSGTGAQRQHGGVNSKNMKAGPLRSLVSFHPLGESLFTSLVLSCPPPAGGEDPAQDLAPWEREEPEDPLLPSPARGPVSLLIGRTAHHVLLSPDETGAEASGCWVAWGTRADLPPARDPFVIDRAKGGPVRASWRRSLLRDFDAFIHAKDPAAAGTKGQILPAWLSVFADLPEEVLDGLGSVRVRALGCHQEKQEKDEHWYAVTTPASIAAFLPLGTHNGPLAWPTPAKRRRVRRPTWPRRCALRGNTWRPARRHAHGLMRPPQRTGTGPSRCSGRRSTGMTQRRRGSAASPWRSTTPPPGRPRPPRKGCTRWPRPVPRSLIPGFLEGGQRPRDHRVPAHPIAEEEPAGAVRTVHAHRSHCMRHTGRPGRLA
>CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MRTVRTACATPGGRAALRNGLAEELTSPWQLYMHLLPAGGIPAYAPNREAEFPYLLVACLYAVHDAPNPRTAKTNPPSAVKPAEMWQNLGWSYALAARVGAMRRENAADALSHLAELGSDDLHRELPGAISLLRSQQIPVKWPVLLRDLTRWPKWADDVRIEWARAFHVPTNRTAEETAQ
>CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MTNFGPGSLYVDVHLIQSYPYSNLNRDRQGAPKTAKYGGAMRARHSSQNGKRHNRTAVEKAIGVRAVRTRGVPHAVAKRLTARGWQPELALAAGQMLILAAGVKGLGIADSGGTNALLFLPESALDELAELADGHRGDITQAVYDIEAEQAKAAKKSTRKKADADLEPAADDEEEPAVGEGSALARYATKILPKAAVLTILQSRNASVAAFGRMLANEAGSIVDGAVQMAHGLSTHAASTQLDYFTAVDDILDEEGTERGAGHMGDQRYTSATFYRYTSMNVTELVSNLDGDTQTAQAVLAEFVRAFVTTVLPAKASGTAPFTVPHLTYIALRSDRPVSLVGAYETPVPDSIEGYLPRSMQRLNDHARAHHRFLGTAGLITHAHSGLTDDAFDALGDRLDGLDELIARVSDTVAKGLA
>CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MSGGLLLHLSGPLQSWGSDADFEVRTTHRWPTRSGLAGLLACCLGRPRDTDNTDLAELSYTIRVDRPGQREMDFHTVGGGYPRHLTPPTADGKFRKLGEGTILTQRWYLTDAAFTIAVTGPAPTLARCAEALQRPRFAPYLGRRSCVPDTPILILDAVTDPVAELDRVPLHRTPARFGHRDPVTFLYDTAPEPGAPPDTEIRDQPGPRRRFADRPVWERQRQLPDAEDAGRGTDWLTALLAYREAAAA
>CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MTTSTASTQTVHLARLHLQARSRDVHRDLKDASRLHTTIQALFPDALGAAPRTATNTLYRIEREQTGAQLLIQSTLPINRNALPSGYTSQVEYRDLTPLLNWVAGGRVVRFRIDGNPIKSVPVPGGGRGRRVPVSGEEALAWWERQAARAGLTNELVLDLPQPDVLGSRSEAKRIRLRAIRFEGVATVTDPEALRAAIITGIGQGRAYGLGLLSIAPYRT
>CP033073.1|AYN40142.1|3569324_3569588_+|hypothetical-protein
MAGWVGQTGLPKRSWIRWDEVFALFVPCLLPQAGCGGERAGEFVSLVGEGERVGAVVAAEQLAYLVGGVAGGAAGERQAVLAVQEFR
>CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'
MIHDLFGSPVWPTQPATGPAAVVTTGLVILADWLVSQLPWIRDRQRRWDRDPTRDWHAHVRRARRAAPKTLREAQLVPPTWRRTRSFHNLFPHLHGKPLHPLQTSLAQSLRPLVANGPGLLLITAPPGEGKTESALFAERIMGPAAGTKSLAFLLPTMATTDAMWARVRAYARANCRTPPPVTLLHAMAWLDAEYTPDQLTTVTSSPDVVAEWLRGRHRGFLAGIAVGTWDQAALAVLPHRFMALRWLGLSGKTVIIDEVHAYDAHGHALTLRLLEWLGALGVPVVLLSATVTGDTAAALVHAYRRGAGHHDTPPINPSYPGWTYTDHATGTITTSPTLGSNRAHTLTVDTITCTHTHNPDHARGRARAILDLLTPLQQIGAGAALVICNTVADAQATRDLLDTAWASHTDRALVRILHARMPARQRAAITRRLQRWTGPHGKRPHQPFVVVTTQVAEQSLDVDFDLVISDLAPFALLLQRAGRGHRHPRSDRPVWAKTPRLAVLIPVGQLPPPAWGDVYPASVLRRTRDLLTTLNDQPINVPGDVQRLVDQVYGPEFAGADDTARLADDAQRTATAHLTAIGAPATVRDLHPLTNTAEHPDQITTRLGADSVRVLPTYLTPDGHHWLHPTHYTPRTALPDRINPEDRGTIRRLMQATIPINSQWLTGRDPTTHIPETWSNIPGLRDLILLPHYVTRTAIGPYRAAGKAISLDPQNGLVRR
>CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein
MGTAAYGSVPALLLALHNSTGGAGYVVTVPELEPGGLLPAALLMAGLLATVLLRSARAPRRWVLPVVAAVTGELLEWTYWLTHSSAGYGPTLLNVLVGCVSVPVLAAFAGAALRWLASGRPARLAAADASRSARWALLLPAVVVMTGDLLGLDLWQSASPGTGIGPSVLGYLVGLALLAAVVGGLVRWPRAAADLATLGLVGIGVYDVAQSGFGQSLVVVQKFGSPRGPAPLLPVETAHHASVLGGIQGAVLLALGLWLLPLTVLPDARRLLGRGPDPALTRRVRELTETRADAVSSAAAELRRIERDLHDGAQGRLVTIGMNLRVAEEMIHSDPHEAAALVVEARVASAAALEELRGLIRGMHPPMLADRGLGEAVRALALDLPLPCDTEIDLPERLAAPLESACYFAVAEVVTNAVRHASAHGLQIRMTHTDGLLRIEVVDDGVGGADPARGTGLAGVERRLAAFDGILAVSSPPGGPTIVVMEVPCV
>CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator
MRVVVAEDLFLLREGLVRLLKARGFEIVAATDSAPGLLGALLEFRPDLAIVDIRLPPTHTDDGLRAALTARERIPGLPILLLSQYVEQIYAQELLADQAGGVGYLLKDRVFSDDQFVDVIRTVAAGGTVMDPEVVTKLLGRRSRGERETLSRLTERERQVLELMAEGRSNSAIANRLFISEKAVSKHSTSIFAKLELAPSDDDNRRVLAVLAYLMSAPREGRLPPGH
>CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase
MTITPFMTQEGMTRRRMLGAALAVGAAVPMGVARPVWAASTAPGPVQLTLPVPTGPYPVGTVPLHLVDASRPDPVAGPGHHRELMASLWYPARRAEDLPRAPWMAEGALRALLTDADFTLDPALGPLTAGRVGAPVHRTGQRLPVIVYSHGSGSHRGDHTIMVQELASHGYAVVTVDHTHDTFTQFPDGRVVTPGDVPMFPRDFAADLRFLLDCVERLAAGRNPDVDGKPLPQGLLGALDPRCIGAFGWSKGGTATALTMLADRRVRAGLSVDGPMQPTITADLDRPFMMMTAVFTRAAMPDVAEFWTHLRGWRLDIQADGAIHNSYGDNATLIPQAGKILGMTTQQIQDWIGTLDPARAVRIQQAYPLAFFDLNLRHRGQGHLLDGPCPAFPEVKFLP
>CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein
MNQVPPSISELTLAATPNAVAWARRHTVDVLQRWRFPAEGIEVARLLVSELATNAILHARRAESSGSSGTGSAGPGVITLRLWPTEHGVVLLVGDADPRPPVLRAGGLGATGGRGLLLTQTMASCWGYYHPGHHPGKIVWAHVPTRPNASLNEPGGASGQLAPPLLIGRILTGLREL
>CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein
MSPSGMPSVDLLGEQIASVLADPATSHGLARALRAAAKEIELHRYHHASRRAWPNGRIDDKPAKVQIGGGAHRIDGFFNIDLVPPADLLWDIREGVPLQDASTDEIFSEHFLEHIDYPRSAKHYVREAHRVLVPGGRIITGVPDAAFALNQYPGPLDASDEMIERWYAKRDCRGHINTCLDLINLVFRDQDDDPTYTPHLWAYDHEKLIQLFTEAGFTTVEPWTFDPAMANPKRRWGSVYVVATK
>CP033073.1|AYN40150.1|3577687_3579082_-|hypothetical-protein
MDFLDAYHLWADAHAFFDSTLIPSPADHTDPLATQAAGWNRRLAEDTPNGHLLRRNALFEALSGNGKLHLLHVTHALEEISQQGVLYPSGGCLVGSIYCAPLTATDRGFRMHNLGAYVLTKEAPTFLAKLGVTDRVPTPLIFEIDTPPQAYRGLAGVDYLRLGLIHLQIYSHLEYLLSKSERHQLRESVVSRVKNSAAFLATAAAVAYQGTRVDAEPFLKLLDETIPRLPILGYLYFEAVAEYLMLHSASHHTRRLAELGELNNWLYKEMLFASFPAMAGKFDLARFRPRPKQLAALIHRVDPTIDTSHASAYLVERISYLVAARLFAPGDAPEAWHHTRWEFDSLATQLGPLLGHLIHRELRTFGRYPDFYFYFDQHKALQAWNYWNHMDIVAPFNGTMPKGEIGINPAYPNLDYRAWRAEQDDAGHLHPAEELSLTIAPRLVDIKYTLMRNNQWTAPAPSAA
>CP033073.1|AYN40151.1|3579084_3579849_-|hypothetical-protein
MSTTPLTASLIDLAARGQLPLHQHMDHATIAWISDNRPSLPPTPQPALRPQSKELLAQGGLPTRWWADPRLHTSLHGVRHAMRAAALAAVLAEANGLDDGDTATAILAAAIHDCQRRHDKDDHGHGARAALWLAANADTVWGHFGLTATPRRIVQAATAVRLHDVPYEAFTADDRIDHARAERITDVVKAADALDRYRLPKLKWWPDARYVREPAFDQLRGLAFDLVLVSERAHLAGASGTEAVRYALAEKGLV
>CP033073.1|AYN40152.1|3579888_3580473_-|hypothetical-protein
MAVEIEMRARFAKEVHDQLVTRLKADGEDLGPDDKHIYFYVLSDQLLKVTDNTAAGTAKITLKGSKIGQGAAFAETEFAIAPADVPAAVKVFNALGFETAMHEAFNFRHNFRFDGVEIAVKWSEAWGYHAEFEVLLEDRASDAARAEAEARITDIAMRLGVTLMTEQELAEFTAAFEAAEKARKEREQQAAPIR
>CP033073.1|AYN40153.1|3580633_3580933_-|hypothetical-protein
MTNPTRLASTDELESIFQRELATDRWAATETAYALAVRHRDLGDWRASREWAQQCLRLLEGFPSETEEQVATGRTSVGGVQLPTYLHSGVVQERFGTLD
>CP033073.1|AYN40154.1|3581013_3581523_-|nucleoside-diphosphate-kinase
MAEVQAHTVERTLVLLKPDALARGLAGRIIARFEDAALKIVGTKMRWMDEEFTRRHYFDLEERLGSEVYNLTATFMQQGPVIALVLEGFDAIATVRKIVGSTYPNQAPAGTVRGDFSHYSAAASIASGKAVANLVHASGNAEEAKQEVELWFDKDELQDYKTLAEIYTY
>CP033073.1|AYN40155.1|3581931_3582591_+|NUDIX-hydrolase
MDVIERWSGRYACLLQSALRLGNEQFAAHLGIAVRTVAAWHSDASVVPRREMQQLLDTAHEQAPEAARQRFALLLAKERAPADSTPPGAQALRVAIAVVVRDSDVLLVCRRDDDAAGIRWQFPAGVIKPGGKAEITTVRETLDETGIHCAVRQQLGNRLHPVTGVLCEYFLCEYLAGEATNSDAVENIDVMWVPRNSVPRFIPVDTIFPPILAVLEEQT
>CP033073.1|AYN40156.1|3582587_3583001_+|NUDIX-hydrolase
MTQQNTDERPGIAAAIVVNEGRVLMVRRRVSEGQLSWQFPAGEVEPGEAREDAAVRETREETGLTVTAVKLLGERVHPKTGRLMSYTACEVLGGTAHVADTEELAELAWVAHGEIPQYVPYGLFEPVQEYLDAALIS
>CP033073.1|AYN40157.1|3583103_3583592_-|hypothetical-protein
MEEYALTRRDHRRQKQSEETSESVRLQVEEDNAKCRADPARAERRRQAFEEVAKLMQSFKKADHEIMRWRVRLYCGHIIEIEAHYTYTDPVSAGAYSKRCPECGEDQQTIVAFEPIGLRAEPPEPTEPTPPPPPKKPTRAELERRVKALEEENERLRAKLTG

Crispr_ID: CP033073_9

• CRISPR_ID: CP033073_9
• CRISPR_location: 3575213-3575785
• CRISPR_type: TypeI-E
• Repeat_type: NA
• Spacer_info: 9 spacers
• Cas_protein_info: cas8e,cse2gr11,cas7,cas5,cas6e,cas3

Consensus repeat of CP033073_9

Consensus_repeat	Method
GTTCGCTCCGCACCCGCGGAGGTCACCCG	PILER-CR
GTTCGCTCCGCACCCGCGGAGGTCACCCGT	CRISPRCasFinder
CGCTCCGCACCCGCGGAGGTC	CRT

spacers of CP033073_9

>9.1|3575242|32|CP033073|PILER-CR
GGGTGGGAGACCGGCGTCCGGTACGAACCGAG
>9.2|3575303|32|CP033073|PILER-CR
GACATCACCGAGCCCGGCGCGTTCTCCATCCT
>9.3|3575364|32|CP033073|PILER-CR
TTTTTGCCCGGCTTCCAGTAGCCAGTGAACGG
>9.4|3575425|32|CP033073|PILER-CR
TGGTCAGCGCTGGACTCGCCGACGCGTGGCCG
>9.5|3575486|32|CP033073|PILER-CR
TCCTCCCGGCTGCTGCTCGTGCGCTCGGGGGA
>9.6|3575547|32|CP033073|PILER-CR
TCGTCCCAGCGGGTCAGCTGCTCGAGCTCGGA
>9.7|3575608|32|CP033073|PILER-CR
TTGTCCACGCAGTCGGCGCCGTGCATGTCGTA
>9.8|3575243|31|CP033073|CRISPRCasFinder
GGTGGGAGACCGGCGTCCGGTACGAACCGAG
>9.9|3575304|31|CP033073|CRISPRCasFinder
ACATCACCGAGCCCGGCGCGTTCTCCATCCT
>9.10|3575365|31|CP033073|CRISPRCasFinder
TTTTGCCCGGCTTCCAGTAGCCAGTGAACGG
>9.11|3575426|31|CP033073|CRISPRCasFinder
GGTCAGCGCTGGACTCGCCGACGCGTGGCCG
>9.12|3575487|31|CP033073|CRISPRCasFinder
CCTCCCGGCTGCTGCTCGTGCGCTCGGGGGA
>9.13|3575548|31|CP033073|CRISPRCasFinder
CGTCCCAGCGGGTCAGCTGCTCGAGCTCGGA
>9.14|3575609|31|CP033073|CRISPRCasFinder
TGTCCACGCAGTCGGCGCCGTGCATGTCGTA
>9.15|3575670|31|CP033073|CRISPRCasFinder
CCTGGCGCATTGCGTCCCACAGATGCCGGTC
>9.16|3575237|40|CP033073|CRT
GCCCGGGGTGGGAGACCGGCGTCCGGTACGAACCGAGGTG
>9.17|3575298|40|CP033073|CRT
GCCCGGACATCACCGAGCCCGGCGCGTTCTCCATCCTGTT
>9.18|3575359|40|CP033073|CRT
ACCCGTTTTTGCCCGGCTTCCAGTAGCCAGTGAACGGGTT
>9.19|3575420|40|CP033073|CRT
ACCCGTGGTCAGCGCTGGACTCGCCGACGCGTGGCCGGTT
>9.20|3575481|40|CP033073|CRT
ACCCTTCCTCCCGGCTGCTGCTCGTGCGCTCGGGGGAGTT
>9.21|3575542|40|CP033073|CRT
ACCCGTCGTCCCAGCGGGTCAGCTGCTCGAGCTCGGAGTT
>9.22|3575603|40|CP033073|CRT
ACCCGTTGTCCACGCAGTCGGCGCCGTGCATGTCGTAGTT
>9.23|3575664|40|CP033073|CRT
ATCCGCCCTGGCGCATTGCGTCCCACAGATGCCGGTCGTT
>9.24|3575725|40|CP033073|CRT
CCCCGTACATGATCGCGGCGGGAGGCGTTACAGGAACGCT

CRISPR arrays and Neighbor proteins around CP033073_9

CRISPR arrays

The CRISPR arrays of CP033073_9

>merge|CP033073|9|3575213-3575785|PILER-CR,CRISPRCasFinder,CRT
GTGCGCTCCGCACCCGCGGAGGTCGCCCGGGGTGGGAGACCGGCGTCCGGTACGAACCGAGGTGCGCTCCGCACCCGCGGAGGTCGCCCGGACATCACCGAGCCCGGCGCGTTCTCCATCCTGTTCGCTCCGCACCCGCGGAGGTCACCCGTTTTTGCCCGGCTTCCAGTAGCCAGTGAACGGGTTCGCTCCGCACCCGCGGAGGTCACCCGTGGTCAGCGCTGGACTCGCCGACGCGTGGCCGGTTCGCTCCGCGCCCGCGGAGGTCACCCTTCCTCCCGGCTGCTGCTCGTGCGCTCGGGGGAGTTCGCTCCGCACCCGCGGAGGTCACCCGTCGTCCCAGCGGGTCAGCTGCTCGAGCTCGGAGTTCGCTTCGCACCCGCGGAGGTCACCCGTTGTCCACGCAGTCGGCGCCGTGCATGTCGTAGTTCGCTCCGCACCCGCGGAGGTCATCCGCCCTGGCGCATTGCGTCCCACAGATGCCGGTCGTTCGCTCCGCGCCTGCGGAGGTGCCCCGTACATGATCGCGGCGGGAGGCGTTACAGGAACGCTCGTTCCGTACGTGGGGAGGTG

>CP033073|9|2|3575213-3575668|PILER-CR
GTGCGCTCCGCACCCGCGGAGGTCGCCCG	GGGTGGGAGACCGGCGTCCGGTACGAACCGAG
GTGCGCTCCGCACCCGCGGAGGTCGCCCG	GACATCACCGAGCCCGGCGCGTTCTCCATCCT
GTTCGCTCCGCACCCGCGGAGGTCACCCG	TTTTTGCCCGGCTTCCAGTAGCCAGTGAACGG
GTTCGCTCCGCACCCGCGGAGGTCACCCG	TGGTCAGCGCTGGACTCGCCGACGCGTGGCCG
GTTCGCTCCGCGCCCGCGGAGGTCACCCT	TCCTCCCGGCTGCTGCTCGTGCGCTCGGGGGA
GTTCGCTCCGCACCCGCGGAGGTCACCCG	TCGTCCCAGCGGGTCAGCTGCTCGAGCTCGGA
GTTCGCTTCGCACCCGCGGAGGTCACCCG	TTGTCCACGCAGTCGGCGCCGTGCATGTCGTA
GTTCGCTCCGCACCCGCGGAGGTCATCCG

>CP033073|9|9|3575213-3575731|CRISPRCasFinder
GTGCGCTCCGCACCCGCGGAGGTCGCCCGG	GGTGGGAGACCGGCGTCCGGTACGAACCGAG
GTGCGCTCCGCACCCGCGGAGGTCGCCCGG	ACATCACCGAGCCCGGCGCGTTCTCCATCCT
GTTCGCTCCGCACCCGCGGAGGTCACCCGT	TTTTGCCCGGCTTCCAGTAGCCAGTGAACGG
GTTCGCTCCGCACCCGCGGAGGTCACCCGT	GGTCAGCGCTGGACTCGCCGACGCGTGGCCG
GTTCGCTCCGCGCCCGCGGAGGTCACCCTT	CCTCCCGGCTGCTGCTCGTGCGCTCGGGGGA
GTTCGCTCCGCACCCGCGGAGGTCACCCGT	CGTCCCAGCGGGTCAGCTGCTCGAGCTCGGA
GTTCGCTTCGCACCCGCGGAGGTCACCCGT	TGTCCACGCAGTCGGCGCCGTGCATGTCGTA
GTTCGCTCCGCACCCGCGGAGGTCATCCGC	CCTGGCGCATTGCGTCCCACAGATGCCGGTC
GTTCGCTCCGCGCCTGCGGAGGTGCCCCGTA

>CP033073|9|2|3575216-3575785|CRT
CGCTCCGCACCCGCGGAGGTC	GCCCGGGGTGGGAGACCGGCGTCCGGTACGAACCGAGGTG
CGCTCCGCACCCGCGGAGGTC	GCCCGGACATCACCGAGCCCGGCGCGTTCTCCATCCTGTT
CGCTCCGCACCCGCGGAGGTC	ACCCGTTTTTGCCCGGCTTCCAGTAGCCAGTGAACGGGTT
CGCTCCGCACCCGCGGAGGTC	ACCCGTGGTCAGCGCTGGACTCGCCGACGCGTGGCCGGTT
CGCTCCGCGCCCGCGGAGGTC	ACCCTTCCTCCCGGCTGCTGCTCGTGCGCTCGGGGGAGTT
CGCTCCGCACCCGCGGAGGTC	ACCCGTCGTCCCAGCGGGTCAGCTGCTCGAGCTCGGAGTT
CGCTTCGCACCCGCGGAGGTC	ACCCGTTGTCCACGCAGTCGGCGCCGTGCATGTCGTAGTT
CGCTCCGCACCCGCGGAGGTC	ATCCGCCCTGGCGCATTGCGTCCCACAGATGCCGGTCGTT
CGCTCCGCGCCTGCGGAGGTG	CCCCGTACATGATCGCGGCGGGAGGCGTTACAGGAACGCT
CGTTCCGTACGTGGGGAGGTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein	unknown	unknown	gnl|CDD|340413
CP033073.1|AYN40142.1|3569324_3569588_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40157.1|3583103_3583592_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|226975
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	gnl|CDD|182031
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	gnl|CDD|378191
CP033073.1|AYN40153.1|3580633_3580933_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40156.1|3582587_3583001_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239217
CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator	unknown	unknown	gnl|CDD|225107
CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase	unknown	unknown	gnl|CDD|335313
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	gnl|CDD|378050
CP033073.1|AYN40154.1|3581013_3581523_-|nucleoside-diphosphate-kinase	unknown	unknown	gnl|CDD|239876
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl|CDD|378153
CP033073.1|AYN40155.1|3581931_3582591_+|NUDIX-hydrolase	unknown	unknown	gnl|CDD|239217
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl|CDD|273842
CP033073.1|AYN40150.1|3577687_3579082_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN40151.1|3579084_3579849_-|hypothetical-protein	unknown	unknown	gnl|CDD|235947
CP033073.1|AYN40152.1|3579888_3580473_-|hypothetical-protein	unknown	unknown	gnl|CDD|143628
CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein	unknown	unknown	gnl|CDD|226951
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	gnl|CDD|187860

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	cas6e	pfam08798_cas6e_CAS-I-E:CAS-IV	5e-42	139.1	0.0
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	1.6e-89	295.7	0.7
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	cas3	cd09639_cas3_CAS-I	1.9e-45	150.2	0.0
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	cd09670_cse2gr11_CAS-I-E	6.1e-21	70.0	0.6
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	3.4e-48	158.5	0.1
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	pfam09481_cas8e_CAS-I-E	7.3e-51	168.2	0.6

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein	gnl|CDD|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	8.24925e-15
CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein	gnl|CDD|226975	COG4627, COG4627, Uncharacterized protein conserved in bacteria [Function unknown].	3.21824e-11
CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'	gnl|CDD|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	4.63158e-61
CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl|CDD|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	9.77282e-15
CP033073.1|AYN40156.1|3582587_3583001_+|NUDIX-hydrolase	gnl|CDD|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	1.77975e-22
CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.35406e-41
CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase	gnl|CDD|335313	pfam03403, PAF-AH_p_II, Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	1.88882e-14
CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE	gnl|CDD|378050	pfam08798, CRISPR_assoc, CRISPR associated protein. This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	2.87054e-47
CP033073.1|AYN40154.1|3581013_3581523_-|nucleoside-diphosphate-kinase	gnl|CDD|239876	cd04413, NDPk_I, Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.	1.40311e-50
CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl|CDD|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	2.84796e-103
CP033073.1|AYN40155.1|3581931_3582591_+|NUDIX-hydrolase	gnl|CDD|239217	cd02883, Nudix_Hydrolase, Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. Members of this family are recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolase include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and "house-cleaning" enzymes. Substrate specificity is used to define child families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required. This superfamily consists of at least nine families: IPP (isopentenyl diphosphate) isomerase, ADP ribose pyrophosphatase, mutT pyrophosphohydrolase, coenzyme-A pyrophosphatase, MTH1-7,8-dihydro-8-oxoguanine-triphosphatase, diadenosine tetraphosphate hydrolase, NADH pyrophosphatase, GDP-mannose hydrolase and the c-terminal portion of the mutY adenine glycosylase.	2.96975e-14
CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl|CDD|273842	TIGR01868, hypothetical_protein, CRISPR-associated protein Cas5/CasD, subtype I-E/ECOLI. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is part of the ECOLI subtype CRISPR/Cas locus, and now characterized as part of the CASCADE complex of that system. It shares a small N-terminal homology region with members of several other CRISPR/Cas subtypes, and we view the families that share this region as being Cas5.	6.767e-40
CP033073.1|AYN40151.1|3579084_3579849_-|hypothetical-protein	gnl|CDD|235947	PRK07152, nadD, nicotinate-nucleotide adenylyltransferase.	2.04404e-05
CP033073.1|AYN40152.1|3579888_3580473_-|hypothetical-protein	gnl|CDD|143628	cd07890, CYTH-like_AC_IV-like, Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily. This subgroup contains class IV ACs and similar proteins. AC catalyzes the conversion of ATP to 3',5'-cyclic AMP (cAMP) and PPi. cAMP is a key signaling molecule which conveys a variety of signals in different cell types. In prokaryotes, cAMP is a catabolite derepression signal which triggers the expression of metabolic pathways including the lactose operon. Six non-homologous classes of ACs have been identified (I-VI). Class IV ACs are found in this group. In bacteria, the gene encoding Class IV AC has been designated cyaB and the protein as AC2. AC-IV occurs in addition to AC-I in bacterial pathogens such as Yersinia pestis (plague disease). The role of AC-IV is unknown but it has been speculated that it may be a factor in pathogenesis, perhaps providing cAMP for a secondary internal signaling function, or for secretion and uptake into host cells, where it may disrupt normal cellular processes. This subgroup belongs to the CYTH/triphosphate tunnel metalloenzyme (TTM)-like superfamily, whose enzymes have a unique active site located within an eight-stranded beta barrel.	4.13397e-05
CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.26096e-30
CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl|CDD|187860	cd09729, Cse1_I-E, CRISPR/Cas system-associated protein Cse1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family.	1.32991e-42

Protein sequences

>CP033073.1|AYN40147.1|3573147_3574818_-|type-I-E-CRISPR-associated-protein-Cse1/CasA
MLRAFNVAEQPCITAVFRRDADSKELASLVPGAEPGGRREVGLRKVLAAAHLVADVEVTNPAVESMLRRLLTALAVRAGGLDVPDLDAWEDRFDALLVAGRFDADAVHAYFDKWRHRFDLYDGQWPFLQDPRLATECSRQAPPGKLVMPRPSGSNQPWLDRTPQQVPVPSGEALGWLLAWRGYGPSGTGAQRQHGGVNSKNMKAGPLRSLVSFHPLGESLFTSLVLSCPPPAGGEDPAQDLAPWEREEPEDPLLPSPARGPVSLLIGRTAHHVLLSPDETGAEASGCWVAWGTRADLPPARDPFVIDRAKGGPVRASWRRSLLRDFDAFIHAKDPAAAGTKGQILPAWLSVFADLPEEVLDGLGSVRVRALGCHQEKQEKDEHWYAVTTPASIAAFLPLGTHNGPLAWPTPAKRRRVRRPTWPRRCALRGNTWRPARRHAHGLMRPPQRTGTGPSRCSGRRSTGMTQRRRGSAASPWRSTTPPPGRPRPPRKGCTRWPRPVPRSLIPGFLEGGQRPRDHRVPAHPIAEEEPAGAVRTVHAHRSHCMRHTGRPGRLA
>CP033073.1|AYN40146.1|3572660_3573203_-|type-I-E-CRISPR-associated-protein-Cse2/CasB
MRTVRTACATPGGRAALRNGLAEELTSPWQLYMHLLPAGGIPAYAPNREAEFPYLLVACLYAVHDAPNPRTAKTNPPSAVKPAEMWQNLGWSYALAARVGAMRRENAADALSHLAELGSDDLHRELPGAISLLRSQQIPVKWPVLLRDLTRWPKWADDVRIEWARAFHVPTNRTAEETAQ
>CP033073.1|AYN40145.1|3571407_3572664_-|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MTNFGPGSLYVDVHLIQSYPYSNLNRDRQGAPKTAKYGGAMRARHSSQNGKRHNRTAVEKAIGVRAVRTRGVPHAVAKRLTARGWQPELALAAGQMLILAAGVKGLGIADSGGTNALLFLPESALDELAELADGHRGDITQAVYDIEAEQAKAAKKSTRKKADADLEPAADDEEEPAVGEGSALARYATKILPKAAVLTILQSRNASVAAFGRMLANEAGSIVDGAVQMAHGLSTHAASTQLDYFTAVDDILDEEGTERGAGHMGDQRYTSATFYRYTSMNVTELVSNLDGDTQTAQAVLAEFVRAFVTTVLPAKASGTAPFTVPHLTYIALRSDRPVSLVGAYETPVPDSIEGYLPRSMQRLNDHARAHHRFLGTAGLITHAHSGLTDDAFDALGDRLDGLDELIARVSDTVAKGLA
>CP033073.1|AYN40144.1|3570664_3571411_-|type-I-E-CRISPR-associated-protein-Cas5/CasD
MSGGLLLHLSGPLQSWGSDADFEVRTTHRWPTRSGLAGLLACCLGRPRDTDNTDLAELSYTIRVDRPGQREMDFHTVGGGYPRHLTPPTADGKFRKLGEGTILTQRWYLTDAAFTIAVTGPAPTLARCAEALQRPRFAPYLGRRSCVPDTPILILDAVTDPVAELDRVPLHRTPARFGHRDPVTFLYDTAPEPGAPPDTEIRDQPGPRRRFADRPVWERQRQLPDAEDAGRGTDWLTALLAYREAAAA
>CP033073.1|AYN40143.1|3570005_3570668_-|type-I-E-CRISPR-associated-protein-Cas6/Cse3/CasE
MTTSTASTQTVHLARLHLQARSRDVHRDLKDASRLHTTIQALFPDALGAAPRTATNTLYRIEREQTGAQLLIQSTLPINRNALPSGYTSQVEYRDLTPLLNWVAGGRVVRFRIDGNPIKSVPVPGGGRGRRVPVSGEEALAWWERQAARAGLTNELVLDLPQPDVLGSRSEAKRIRLRAIRFEGVATVTDPEALRAAIITGIGQGRAYGLGLLSIAPYRT
>CP033073.1|AYN40142.1|3569324_3569588_+|hypothetical-protein
MAGWVGQTGLPKRSWIRWDEVFALFVPCLLPQAGCGGERAGEFVSLVGEGERVGAVVAAEQLAYLVGGVAGGAAGERQAVLAVQEFR
>CP033073.1|AYN40141.1|3567208_3569374_-|CRISPR-associated-helicase-Cas3'
MIHDLFGSPVWPTQPATGPAAVVTTGLVILADWLVSQLPWIRDRQRRWDRDPTRDWHAHVRRARRAAPKTLREAQLVPPTWRRTRSFHNLFPHLHGKPLHPLQTSLAQSLRPLVANGPGLLLITAPPGEGKTESALFAERIMGPAAGTKSLAFLLPTMATTDAMWARVRAYARANCRTPPPVTLLHAMAWLDAEYTPDQLTTVTSSPDVVAEWLRGRHRGFLAGIAVGTWDQAALAVLPHRFMALRWLGLSGKTVIIDEVHAYDAHGHALTLRLLEWLGALGVPVVLLSATVTGDTAAALVHAYRRGAGHHDTPPINPSYPGWTYTDHATGTITTSPTLGSNRAHTLTVDTITCTHTHNPDHARGRARAILDLLTPLQQIGAGAALVICNTVADAQATRDLLDTAWASHTDRALVRILHARMPARQRAAITRRLQRWTGPHGKRPHQPFVVVTTQVAEQSLDVDFDLVISDLAPFALLLQRAGRGHRHPRSDRPVWAKTPRLAVLIPVGQLPPPAWGDVYPASVLRRTRDLLTTLNDQPINVPGDVQRLVDQVYGPEFAGADDTARLADDAQRTATAHLTAIGAPATVRDLHPLTNTAEHPDQITTRLGADSVRVLPTYLTPDGHHWLHPTHYTPRTALPDRINPEDRGTIRRLMQATIPINSQWLTGRDPTTHIPETWSNIPGLRDLILLPHYVTRTAIGPYRAAGKAISLDPQNGLVRR
>CP033073.1|AYN40140.1|3561015_3562488_-|hypothetical-protein
MGTAAYGSVPALLLALHNSTGGAGYVVTVPELEPGGLLPAALLMAGLLATVLLRSARAPRRWVLPVVAAVTGELLEWTYWLTHSSAGYGPTLLNVLVGCVSVPVLAAFAGAALRWLASGRPARLAAADASRSARWALLLPAVVVMTGDLLGLDLWQSASPGTGIGPSVLGYLVGLALLAAVVGGLVRWPRAAADLATLGLVGIGVYDVAQSGFGQSLVVVQKFGSPRGPAPLLPVETAHHASVLGGIQGAVLLALGLWLLPLTVLPDARRLLGRGPDPALTRRVRELTETRADAVSSAAAELRRIERDLHDGAQGRLVTIGMNLRVAEEMIHSDPHEAAALVVEARVASAAALEELRGLIRGMHPPMLADRGLGEAVRALALDLPLPCDTEIDLPERLAAPLESACYFAVAEVVTNAVRHASAHGLQIRMTHTDGLLRIEVVDDGVGGADPARGTGLAGVERRLAAFDGILAVSSPPGGPTIVVMEVPCV
>CP033073.1|AYN40139.1|3560341_3561025_-|DNA-binding-response-regulator
MRVVVAEDLFLLREGLVRLLKARGFEIVAATDSAPGLLGALLEFRPDLAIVDIRLPPTHTDDGLRAALTARERIPGLPILLLSQYVEQIYAQELLADQAGGVGYLLKDRVFSDDQFVDVIRTVAAGGTVMDPEVVTKLLGRRSRGERETLSRLTERERQVLELMAEGRSNSAIANRLFISEKAVSKHSTSIFAKLELAPSDDDNRRVLAVLAYLMSAPREGRLPPGH
>CP033073.1|AYN40138.1|3559051_3560251_-|acetylhydrolase
MTITPFMTQEGMTRRRMLGAALAVGAAVPMGVARPVWAASTAPGPVQLTLPVPTGPYPVGTVPLHLVDASRPDPVAGPGHHRELMASLWYPARRAEDLPRAPWMAEGALRALLTDADFTLDPALGPLTAGRVGAPVHRTGQRLPVIVYSHGSGSHRGDHTIMVQELASHGYAVVTVDHTHDTFTQFPDGRVVTPGDVPMFPRDFAADLRFLLDCVERLAAGRNPDVDGKPLPQGLLGALDPRCIGAFGWSKGGTATALTMLADRRVRAGLSVDGPMQPTITADLDRPFMMMTAVFTRAAMPDVAEFWTHLRGWRLDIQADGAIHNSYGDNATLIPQAGKILGMTTQQIQDWIGTLDPARAVRIQQAYPLAFFDLNLRHRGQGHLLDGPCPAFPEVKFLP
>CP033073.1|AYN40148.1|3576231_3576765_-|ATP-binding-protein
MNQVPPSISELTLAATPNAVAWARRHTVDVLQRWRFPAEGIEVARLLVSELATNAILHARRAESSGSSGTGSAGPGVITLRLWPTEHGVVLLVGDADPRPPVLRAGGLGATGGRGLLLTQTMASCWGYYHPGHHPGKIVWAHVPTRPNASLNEPGGASGQLAPPLLIGRILTGLREL
>CP033073.1|AYN40149.1|3576886_3577624_-|methyltransferase-domain-containing-protein
MSPSGMPSVDLLGEQIASVLADPATSHGLARALRAAAKEIELHRYHHASRRAWPNGRIDDKPAKVQIGGGAHRIDGFFNIDLVPPADLLWDIREGVPLQDASTDEIFSEHFLEHIDYPRSAKHYVREAHRVLVPGGRIITGVPDAAFALNQYPGPLDASDEMIERWYAKRDCRGHINTCLDLINLVFRDQDDDPTYTPHLWAYDHEKLIQLFTEAGFTTVEPWTFDPAMANPKRRWGSVYVVATK
>CP033073.1|AYN40150.1|3577687_3579082_-|hypothetical-protein
MDFLDAYHLWADAHAFFDSTLIPSPADHTDPLATQAAGWNRRLAEDTPNGHLLRRNALFEALSGNGKLHLLHVTHALEEISQQGVLYPSGGCLVGSIYCAPLTATDRGFRMHNLGAYVLTKEAPTFLAKLGVTDRVPTPLIFEIDTPPQAYRGLAGVDYLRLGLIHLQIYSHLEYLLSKSERHQLRESVVSRVKNSAAFLATAAAVAYQGTRVDAEPFLKLLDETIPRLPILGYLYFEAVAEYLMLHSASHHTRRLAELGELNNWLYKEMLFASFPAMAGKFDLARFRPRPKQLAALIHRVDPTIDTSHASAYLVERISYLVAARLFAPGDAPEAWHHTRWEFDSLATQLGPLLGHLIHRELRTFGRYPDFYFYFDQHKALQAWNYWNHMDIVAPFNGTMPKGEIGINPAYPNLDYRAWRAEQDDAGHLHPAEELSLTIAPRLVDIKYTLMRNNQWTAPAPSAA
>CP033073.1|AYN40151.1|3579084_3579849_-|hypothetical-protein
MSTTPLTASLIDLAARGQLPLHQHMDHATIAWISDNRPSLPPTPQPALRPQSKELLAQGGLPTRWWADPRLHTSLHGVRHAMRAAALAAVLAEANGLDDGDTATAILAAAIHDCQRRHDKDDHGHGARAALWLAANADTVWGHFGLTATPRRIVQAATAVRLHDVPYEAFTADDRIDHARAERITDVVKAADALDRYRLPKLKWWPDARYVREPAFDQLRGLAFDLVLVSERAHLAGASGTEAVRYALAEKGLV
>CP033073.1|AYN40152.1|3579888_3580473_-|hypothetical-protein
MAVEIEMRARFAKEVHDQLVTRLKADGEDLGPDDKHIYFYVLSDQLLKVTDNTAAGTAKITLKGSKIGQGAAFAETEFAIAPADVPAAVKVFNALGFETAMHEAFNFRHNFRFDGVEIAVKWSEAWGYHAEFEVLLEDRASDAARAEAEARITDIAMRLGVTLMTEQELAEFTAAFEAAEKARKEREQQAAPIR
>CP033073.1|AYN40153.1|3580633_3580933_-|hypothetical-protein
MTNPTRLASTDELESIFQRELATDRWAATETAYALAVRHRDLGDWRASREWAQQCLRLLEGFPSETEEQVATGRTSVGGVQLPTYLHSGVVQERFGTLD
>CP033073.1|AYN40154.1|3581013_3581523_-|nucleoside-diphosphate-kinase
MAEVQAHTVERTLVLLKPDALARGLAGRIIARFEDAALKIVGTKMRWMDEEFTRRHYFDLEERLGSEVYNLTATFMQQGPVIALVLEGFDAIATVRKIVGSTYPNQAPAGTVRGDFSHYSAAASIASGKAVANLVHASGNAEEAKQEVELWFDKDELQDYKTLAEIYTY
>CP033073.1|AYN40155.1|3581931_3582591_+|NUDIX-hydrolase
MDVIERWSGRYACLLQSALRLGNEQFAAHLGIAVRTVAAWHSDASVVPRREMQQLLDTAHEQAPEAARQRFALLLAKERAPADSTPPGAQALRVAIAVVVRDSDVLLVCRRDDDAAGIRWQFPAGVIKPGGKAEITTVRETLDETGIHCAVRQQLGNRLHPVTGVLCEYFLCEYLAGEATNSDAVENIDVMWVPRNSVPRFIPVDTIFPPILAVLEEQT
>CP033073.1|AYN40156.1|3582587_3583001_+|NUDIX-hydrolase
MTQQNTDERPGIAAAIVVNEGRVLMVRRRVSEGQLSWQFPAGEVEPGEAREDAAVRETREETGLTVTAVKLLGERVHPKTGRLMSYTACEVLGGTAHVADTEELAELAWVAHGEIPQYVPYGLFEPVQEYLDAALIS
>CP033073.1|AYN40157.1|3583103_3583592_-|hypothetical-protein
MEEYALTRRDHRRQKQSEETSESVRLQVEEDNAKCRADPARAERRRQAFEEVAKLMQSFKKADHEIMRWRVRLYCGHIIEIEAHYTYTDPVSAGAYSKRCPECGEDQQTIVAFEPIGLRAEPPEPTEPTPPPPPKKPTRAELERRVKALEEENERLRAKLTG

Crispr_ID: CP033073_11

• CRISPR_ID: CP033073_11
• CRISPR_location: 4900383-4900454
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP033073_11

Consensus_repeat	Method
GTCCGGCAAGGCGGCCGGTGCCG	CRISPRCasFinder

spacers of CP033073_11

>11.1|4900406|25|CP033073|CRISPRCasFinder
GTGGCGTCAAGGGTTCCGGTGACGC

CRISPR arrays and Neighbor proteins around CP033073_11

CRISPR arrays

The CRISPR arrays of CP033073_11

>merge|CP033073|11|4900383-4900454|CRISPRCasFinder
CTCCGGCGGGACTGGCGGTTCCGGTGGCGTCAAGGGTTCCGGTGACGCTTCCGGTAAGCGGTCCGGCGCCGG

>CP033073|11|11|4900383-4900454|CRISPRCasFinder
CTCCGGCGGGACTGGCGGTTCCG	GTGGCGTCAAGGGTTCCGGTGACGC
TTCCGGTAAGCGGTCCGGCGCCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN41103.1|4894772_4895510_+|ribonuclease-PH	unknown	unknown	gnl|CDD|178914
CP033073.1|AYN41112.1|4905682_4906285_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl|CDD|234648
CP033073.1|AYN41108.1|4903598_4903919_-|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter	unknown	unknown	gnl|CDD|171110
CP033073.1|AYN41113.1|4906311_4907655_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
CP033073.1|AYN41102.1|4894443_4894677_+|PTS-sugar-transporter	unknown	unknown	gnl|CDD|238130
CP033073.1|AYN41104.1|4895730_4896138_+|hypothetical-protein	unknown	unknown	gnl|CDD|131391
CP033073.1|AYN41105.1|4896229_4897024_-|DUF1707-domain-containing-protein	unknown	unknown	gnl|CDD|377959
CP033073.1|AYN43811.1|4907851_4909165_+|DUF445-domain-containing-protein	unknown	unknown	gnl|CDD|377281
CP033073.1|AYN43810.1|4897033_4898017_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213234
CP033073.1|AYN41098.1|4888378_4889329_+|cysteine-synthase	unknown	unknown	gnl|CDD|273463
CP033073.1|AYN41106.1|4897997_4898789_-|transporter	unknown	unknown	gnl|CDD|253605
CP033073.1|AYN41099.1|4889410_4889860_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN41101.1|4892948_4894259_-|PTS-lactose-transporter-subunit-IIC	unknown	unknown	gnl|CDD|273920
CP033073.1|AYN41110.1|4904495_4904825_-|DUF3618-domain-containing-protein	unknown	unknown	gnl|CDD|378834
CP033073.1|AYN41115.1|4911286_4911589_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN41111.1|4904918_4905386_+|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl|CDD|224146
CP033073.1|AYN41114.1|4909325_4910801_+|MFS-transporter	unknown	unknown	gnl|CDD|340874
CP033073.1|AYN41109.1|4904081_4904441_-|co-chaperone-GroES	unknown	unknown	gnl|CDD|197951
CP033073.1|AYN41100.1|4889950_4890409_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl|CDD|367091
CP033073.1|AYN41107.1|4900773_4903596_+|penicillin-binding-protein	unknown	unknown	gnl|CDD|223815

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN41103.1|4894772_4895510_+|ribonuclease-PH	gnl|CDD|178914	PRK00173, rph, ribonuclease PH; Reviewed.	6.51994e-169
CP033073.1|AYN41112.1|4905682_4906285_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl|CDD|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	6.90399e-101
CP033073.1|AYN41108.1|4903598_4903919_-|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter	gnl|CDD|171110	PRK11431, PRK11431, quaternary ammonium compound efflux SMR transporter SugE.	8.90113e-28
CP033073.1|AYN41113.1|4906311_4907655_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.26234e-80
CP033073.1|AYN41102.1|4894443_4894677_+|PTS-sugar-transporter	gnl|CDD|238130	cd00212, PTS_IIB_glc, PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	1.15848e-23
CP033073.1|AYN41104.1|4895730_4896138_+|hypothetical-protein	gnl|CDD|131391	TIGR02338, Prefoldin_subunit_beta, prefoldin, beta subunit, archaeal. Chaperonins are cytosolic, ATP-dependent molecular chaperones, with a conserved toroidal architecture, that assist in the folding of nascent and/or denatured polypeptide chains. The group I chaperonin system consists of GroEL and GroES, and is found (usually) in bacteria and organelles of bacterial origin. The group II chaperonin system, called the thermosome in Archaea and TRiC or CCT in the Eukaryota, is structurally similar but only distantly related. Prefoldin, also called GimC, is a complex in Archaea and Eukaryota, that works with group II chaperonins. Members of this protein family are the archaeal clade of the beta class of prefoldin subunit. Closely related, but outside the scope of this family are the eukaryotic beta-class prefoldin subunits, Gim-1,3,4 and 6. The alpha class prefoldin subunits are more distantly related.	0.0014364
CP033073.1|AYN41105.1|4896229_4897024_-|DUF1707-domain-containing-protein	gnl|CDD|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	1.87215e-19
CP033073.1|AYN43811.1|4907851_4909165_+|DUF445-domain-containing-protein	gnl|CDD|377281	pfam04286, DUF445, Protein of unknown function (DUF445). Predicted to be a membrane protein.	1.91674e-129
CP033073.1|AYN43810.1|4897033_4898017_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213234	cd03267, ABC_NatA_like, ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA. NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.	2.23399e-126
CP033073.1|AYN41098.1|4888378_4889329_+|cysteine-synthase	gnl|CDD|273463	TIGR01136, Cysteine_synthase, cysteine synthase. This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family].	5.75749e-139
CP033073.1|AYN41106.1|4897997_4898789_-|transporter	gnl|CDD|253605	pfam06182, ABC2_membrane_6, ABC-2 family transporter protein. This family acts as the transmembrane domain (TMD) of ABC transporters. The family includes proteins responsible for the transport of herbicides.	1.21044e-61
CP033073.1|AYN41101.1|4892948_4894259_-|PTS-lactose-transporter-subunit-IIC	gnl|CDD|273920	TIGR01998, N-acetylglucosamine_and_glucose_PTS, PTS system, N-acetylglucosamine-specific IIBC component. This model represents the combined B and C domains of the PTS transport system enzyme II specific for N-acetylglucosamine transport. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name "PTS system, N-acetylglucosamine-specific IIABC component". This family is most closely related to the glucose-specific PTS enzymes. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	1.43437e-122
CP033073.1|AYN41110.1|4904495_4904825_-|DUF3618-domain-containing-protein	gnl|CDD|378834	pfam12277, DUF3618, Protein of unknown function (DUF3618). This domain family is found in bacteria, and is approximately 50 amino acids in length.	1.25013e-08
CP033073.1|AYN41111.1|4904918_4905386_+|thioredoxin-dependent-thiol-peroxidase	gnl|CDD|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	9.43466e-70
CP033073.1|AYN41114.1|4909325_4910801_+|MFS-transporter	gnl|CDD|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.79545e-32
CP033073.1|AYN41109.1|4904081_4904441_-|co-chaperone-GroES	gnl|CDD|197951	smart00883, Cpn10, Chaperonin 10 Kd subunit. The chaperonins are 'helper' molecules required for correct folding and subsequent assembly of some proteins. These are required for normal cell growth, and are stress-induced, acting to stabilise or protect disassembled polypeptides under heat-shock conditions. Type I chaperonins present in eubacteria, mitochondria and chloroplasts require the concerted action of 2 proteins, chaperonin 60 (cpn60) and chaperonin 10 (cpn10). The 10 kDa chaperonin (cpn10 - or groES in bacteria) exists as a ring-shaped oligomer of between six to eight identical subunits, while the 60 kDa chaperonin (cpn60 - or groEL in bacteria) forms a structure comprising 2 stacked rings, each ring containing 7 identical subunits. These ring structures assemble by self-stimulation in the presence of Mg2+-ATP. The central cavity of the cylindrical cpn60 tetradecamer provides as isolated environment for protein folding whilst cpn-10 binds to cpn-60 and synchronizes the release of the folded protein in an Mg2+-ATP dependent manner. The binding of cpn10 to cpn60 inhibits the weak ATPase activity of cpn60.	1.36229e-27
CP033073.1|AYN41100.1|4889950_4890409_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl|CDD|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	1.7195e-05
CP033073.1|AYN41107.1|4900773_4903596_+|penicillin-binding-protein	gnl|CDD|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	7.76483e-135

Protein sequences

>CP033073.1|AYN41106.1|4897997_4898789_-|transporter
MRAYRLVAGMWVRSTMAYRASFAMTTFGNFAATFFDFVTIMLMFSRVDTLGGYSLPEVAFLYGLSATSFGLADLVIGSMDRLGRRVRDGTLDTLLVRPAPVLAQVAADRFALRRLGRVTQGALVLGWSLTRLDIAWTVPKVLLLPVTVVSGFGIFAAVFVAGAAFQFLAQDASEVQNAFTYGGTTLLQYPPTVFAKELVRGVTFVLPLAFVNWLPACYVLGRPYPLDLPEWAAFTPPLVAVGCCAAAGLAWRAGLRSYRGTGS
>CP033073.1|AYN43810.1|4897033_4898017_-|ATP-binding-cassette-domain-containing-protein
MAAQGVSVNDFIALEKVEKVFEVRRKAGFLKRERHEVRAVDSISFTVARGEMVGYIGPNGAGKSTTIKMLTGILTPSAGRLRVAGIDPARERVRLAHRIGVVFGQRTTLWWDLPLADSYRLAHRMYRIPDARYRQNLDRLVELLDLGALLDVPVRQLSLGQRMRGDIAAALLHDPEVLYLDEPTIGLDVVSKARVREFLREVNAERGTTVLLTTHDLQDIEQLCSRVMVIDHGRLVHDGSLAGLHEAGESERTLVVDLERELPPVEVASARVVRVEGPRQWLAFPAGRSAAPLVADLAARYPLVDLSVREPDIEAVIARMYAERAVS
>CP033073.1|AYN41105.1|4896229_4897024_-|DUF1707-domain-containing-protein
MSDDAAPDLRASDADRERVAEILRDALAEGRLVMEEFEERLEAACTARTYGELAPLTRDLPGAGAVAPAPVSFTKAPVGDGGWADRITGGAGSSAWAVALLSGFERKGRWTVPRRFNCFALLGGGVIDLRDADFAEREVEIFCVAVMGGLQVVVPPGVEVDVRGIGVMGTFAHPPGDVPSAPGAPRVVVGGFAFWGGVGVERKLSRAQRQRLKERRRQEKLERRESRHELRRARRAERHALDPARRIGRRDEQRERQRYRGGER
>CP033073.1|AYN41104.1|4895730_4896138_+|hypothetical-protein
MAASRRSRRHRVTAIAAAVAAAALTAGLTTGCDAVNKALDCVQTADAIADNVTDLQQAVENAADDPSQTDASLDSIEKSLRKIGDKTDDTDVNKAVDDLNQAIGNVRAAIRDGDDTPDVGPVTDAAGELTKVCTS
>CP033073.1|AYN41103.1|4894772_4895510_+|ribonuclease-PH
MSRIDGRTPEQLRPVTIERGWSKHAEGSVLVSFGDTRVLCTASVTEGVPRWRKGSGEGWVTAEYAMLPRATNTRGDRESVKGRIGGRTHEISRLIGRSLRAVIDYKALGENTVVLDCDVLQADGGTRTAAITGAYVALADAVAWAQGRKLVKAGRKPLTGTVSAVSVGIVGGVPLLDLCYEEDVRAETDMNVVCTGDGRFVEVQGTAEAQPFARAELDALLDLAVAGCADLTALQQAALERTRES
>CP033073.1|AYN41102.1|4894443_4894677_+|PTS-sugar-transporter
MASKAEKIVAGLGGIDNIEEIEGCITRLRTEVSDPSLVDDTALKAAGAHGVVRMGTAIQVVIGTDADPLAAEIEDMM
>CP033073.1|AYN41101.1|4892948_4894259_-|PTS-lactose-transporter-subunit-IIC
MSAESAAGPARVHFNRLFQGLQKMGRSLQLPIAVLPAAGILNRLGQPDVFGDQGLGWTGVSKVMKGAGGALLDGSLGLPLLFCVGVAIGMAKKSDGSTALAAVAGFLVYYNVLHQFPGRCPGGSTSVPDVGCQVSVGAGAGAVTPFTFQNPGVFGGIVMGLLAAFFWARYHRTRLVDWLGFFNGRRLVPIIMAFVAIAFAALCLWVWPPVGDALESFAHWLRDLGARGAGLFGLANRALLVIGLHQFLNVPVWFQFGTYTPPGGKPVHGDINMFLAGDPHAGQFTTGFFPIMMFALPAAALAITHCARPERRKEVGGLMLSVALTSFVTGITEPLEYSFLFVAPALYAVHAVLTGVCLGASWALGVHDGFSFSAGLIDYVINWNLATKPWAIIPIGLAFAAVYYAVFRFAITRFDLRTPGREPAEVAQEMDRDNVR
>CP033073.1|AYN41100.1|4889950_4890409_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MDTSWWLALAAVVLLALVATLVDGWGRGRRPGGRRLRPPGRPGTRTARAARPSPGDIWWADVPYEDRAAVKDRPCLVLAVRGDRATVAKITSKYHDERSGVIPLPPGAVGDARGRPSFLETDELREVPVGDFRRRVGVVDPVLWDQVRHLAG
>CP033073.1|AYN41099.1|4889410_4889860_+|hypothetical-protein
MRRTTPLALAAAALLLAGCGSQQEDTGSGGKASEPPSPTRSAGGCTGQADLTAADHGRTVCVTEGGEVRLTLDGTRARPWKAVTASGTGLRGINAGFVLRPGDATAAYRAVAAGTVRLTSSRPLCAEPTAPDRVSCKGVEEWTVTVRVG
>CP033073.1|AYN41098.1|4888378_4889329_+|cysteine-synthase
MRYDSPLAAVGNTPLVRLPRLSPSSDVRIWAKLEDRNPTGSVKDRPALHMIEQAEKDGRLTPGCTVLEPTSGNTGISLAMAAKLKGYRMVCVMPENTSRERRDLLGMWGAEIISSPAAGGSNTAVRVAKELAAEHPDWVMLYQYGNPDNAGAHYATTGPEILADLPSITHFVAGLGTTGTLMGVGRFLREHKPDVKIVAAEPRYDDLVYGLRNLDEGFVPELYDASVLTTRFSVGSADAVTRTRELLQQEGIFAGVSTGAALHAAIGVGRKAVQAGESADIVFVVADGGWKYLSTGVYTAATTEEAIETLQGQLWA
>CP033073.1|AYN41107.1|4900773_4903596_+|penicillin-binding-protein
MLRRVGAPRSGEPGDAGASSAGKQDPAGRTPRASVPRPAGRNSGTGPAAKSAGATAAVAATGAAAASSPAAARAARAARAAGAAGAAAGAVAGAASAAGAAAQASPAGAGAAARPGSSEAETTALAATDGPAGGGSDSGKGKGKAADGGGKGKRPRRTGLRRLLPTWRMVLGTFVVGVLLVVGLFFVGYSLVQIPSANAFATKQANVYLYADGSQIARDTRDSQVNRENVGLAEISKDAQHAALAAEDRDFYTESAVDLKAMLRAGWNTATGKGKQSGSTITQQYVKNYYLGQEQTVTRKAKEFFISIKLDREKSKNEILEGYLNTSYFGRGAYGIQAAAQAYYGRDAADLDPARAAYLAALVNAPSEYDVVAHPENRKAAVARWNYVLDGMVKKGWLSQGERAGAKFPMPKQQILSTGLSGQRGYLVDAVRHYLITNKIVTADQLQAGGYRITTTIQKKKQDAFVKAVDDQLMSKLDKENRKADTYVRAGGASVDPKTGEVVAMYGGVDYVKQYTNGATRGDFQVGSTFKPFVFTSAVENGSTTQDGRTITPNTIYDGTNKRLVQGWSGAPYNPENEDQKSYGPITVGKATDLSVNSVYAQMAADVGPAKVKQTAVDLGIPAGTPDLYPSPSMALGTANASVLDMAEAYATLANHGKHGTYTLVQKITKDGTEPMELPGRPARQAVSREAADTTTSVLRSVVESGTATAAQNAGRPAAGKTGTAESDTAAWFAGYTPDLATVVSVMGQDPVTAKHMPLYGALGVNRMNGGGPPTQIWAQYTRDALKGKPAGAFDLQLQTGADQPQAPGTTAPTQPGTDAGQGTGGTATDGGTAGGGATATPTDGGTTGTPTDGGTATDGGTPTDGGTATGGGTTTTTGTGGDTTGGDGTTTDGGVPTGGGTTGGGGPTTGGGGTAGGGTQGGNTTGTDTGTGTGGFPGT
>CP033073.1|AYN41108.1|4903598_4903919_-|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter
MAWVLLVVAGLLEVGWSVGMKYSEGFTRPVPSLFTGAGIVASMILLSYAARSLPIGTAYGVWVGIGAAGAAVLGMVVLGEPVTAARVFFVCLLLVAVVGLKATGGH
>CP033073.1|AYN41109.1|4904081_4904441_-|co-chaperone-GroES
MSANRNEHSTPHHDKLPIRMLHDRVLVRQETGEGERRSGGGILIPATAAVGRRLAWAEVVAVGQNVRTVEPGDRVLFDPEDRAEVEVRGVAYVLMRERDLHAVAADRFEGSEDSTGLYL
>CP033073.1|AYN41110.1|4904495_4904825_-|DUF3618-domain-containing-protein
MADTSDTRTPAQIEAAIRRRREVLAETLDEIGVRVHPKTIVGDAKAKVVANVDHTVGRAYVQVNRVVSELRGQFVDEEGAPRPERVVPAALVVVGVVGLLALASRRRRG
>CP033073.1|AYN41111.1|4904918_4905386_+|thioredoxin-dependent-thiol-peroxidase
MSERLQPGDVAPAFTLPDADGNDVSLSDHEGRKVIVYFYPAALTPGCTKQACDFTDNLQLLADAGYDVIGVSPDEPEKLAKFREKESLRITLLADPDKRVTEAYGAYGEKKNYGKTYLGVIRSTVIVDEQGKVERALYNVRATGHVAKIIKDLGI
>CP033073.1|AYN41112.1|4905682_4906285_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MTRLILATRNAGKITELRAILAEAGLPHGLTGADAYPDIPDVRETGVTFAENALLKAHALARATGLPAVADDSGLCVDVLGGAPGIFSARWAGRHGDDRANLELLLAQLSDIADEHRGAHFACAAALALPDGTERVVEGRLRGVLRHAPAGTNGFGYDPILQPEDETRTCAELSPREKNAISHRGKAFRALVPVVRELVG
>CP033073.1|AYN41113.1|4906311_4907655_-|SGNH/GDSL-hydrolase-family-protein
MTKRHGYAVLCALVALVAALSAAIYVTVAADDGTAGTVRGTLADSRPHRDSAAAPASTGTWVGAWATAPVGGEPGTEAAGMAGRSVRNVVHTATGGTSARITLSNLYGQSPLTLTHATIALSAGDGTAAADATTMRRLTFDGGTGVVVPAGGQTVSDAVRLTIPRGSDVLVTTYSPTASGPVTYHPHARQTSFVADGERAEDVTGAPYTQQTPYWRYLTALDVLSNEADGTVVVFGDSITDGITSTTGANHRWPDILAGRLRGALEGGRQLPRYSVVNEGISGNQVLADGLGRPAENQSGLGRFGRDTLSRTNARAVVIDLGVNDILRNRELADPDRIVTGLRTLVRQAHARGLKAVGATLMPFRGHRGFTPAREAVRQQVNARIRAGGVYDAVVDFDRALRDPYDPRRLRAEYDSGDHLHPGDLGFARMAEVFDLRTLRGAGQTEL
>CP033073.1|AYN43811.1|4907851_4909165_+|DUF445-domain-containing-protein
MEPTETGTQGRGTSYRTMTAFTPADEERRRGVRRMKLTAAGLLLLVAVVYVLAKVAGHAGAGTWTGYVAAAAEAGMVGALADWFAVTALFRHPLGLPIPHTAIIPNKKDQLGVSLGEFVGENFLSEDVVRQRLRAVGIGGRLGTWLAEPEHADRVTAELATALRGALTVLRDSDVQAVVGEAITRRADAREIAPRLGTMLEKVVADGGHRRVVDLVVTRAHDWLVLHRDDVMVAVEGGAPGWTPRFVDRKVGERVYKELLRFVIEMRDMPSHPARGALDRFLTDFAADLQSDTDTRARVERLKTEVLGRGEVQELIASAWTAVRSMIVAAADDERSELRLRVRAALLSLGTRMATESKVQGKVDSWVEGAAVHVVTTYRKEITSLITDTVAGWDAEHTTRKIEAHIGRDLQFIRINGTVVGSLAGLLIYTVSRGLGA
>CP033073.1|AYN41114.1|4909325_4910801_+|MFS-transporter
MSTAQAERGRTITTDIPARLDRLPWSRWHWTIVIGLGTVWILDGLEVTVVGNIASRLSEPGSGLSISSGQVTGTAAALYVAGACVGALFWGRLTDRFGRKNLFMITLAVYLAATAMTAVSWEAWWFFLFRFLTGFGIGGEYAAINSAIDELIPANYRGRVDLIINGSFWLGAVGGSLLSIVALDTDLLAADVGWRLTFALGTVLALVILLVRRHVPESPRWLLIHGRDREAEDIVTGIERRVEAEKGERLPRPEGELEIRQRKNVTFLEIARTVFGQYRKRAVLGFSLFVGQAFLYNAITFGFGAILTKFYDVPADRTGYYFAVIAIGNFCGPLLLGRFFDTVGRRVMISSTYILSGLLLFGTAWLFGRGSLSAVTLTACWCAVLFFASAGASSAYLTVSEIFPMETRAMSIAFFYALGTAAGGISGPLLFADLTNTGRVGDTVLAFSIGAGLMCAAGLVAAALAVRAERRSLEDVARPLTAVTGRAKTAA
>CP033073.1|AYN41115.1|4911286_4911589_-|hypothetical-protein
MARVPSAVVAATGLVGGYGVARWTKKRQLGGVVLTVAGAAAARQWQRQAGGTAAGALTAAYVAAFAGSHPLAKKVGAWPSVLGVAGAVALTSWAVADRKA

Crispr_ID: CP033073_12

• CRISPR_ID: CP033073_12
• CRISPR_location: 4900614-4900745
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of CP033073_12

Consensus_repeat	Method
GTCCGGCAAGGCGGCCGGTGCCG	CRISPRCasFinder

spacers of CP033073_12

>12.1|4900637|19|CP033073|CRISPRCasFinder
CAGAGGCGTCCGGCAAGGC
>12.2|4900679|43|CP033073|CRISPRCasFinder
GTACGGCCGCCGGTTCCGACGGGGCGGCGGGTGCTGCCCAGGG

CRISPR arrays and Neighbor proteins around CP033073_12

CRISPR arrays

The CRISPR arrays of CP033073_12

>merge|CP033073|12|4900614-4900745|CRISPRCasFinder
GGCGGGTCAGGCGTCCGGTGCCGCAGAGGCGTCCGGCAAGGCGGCCGGTGCCGCCGCGGGTGCCGGTACGGCCGCCGGTTCCGACGGGGCGGCGGGTGCTGCCCAGGGTTCCGGCAAGGCGGCCGGTGCCGG

>CP033073|12|12|4900614-4900745|CRISPRCasFinder
GGCGGGTCAGGCGTCCGGTGCCG	CAGAGGCGTCCGGCAAGGC
GGCCGGTGCCGCCGCGGGTGCCG	GTACGGCCGCCGGTTCCGACGGGGCGGCGGGTGCTGCCCAGGG
TTCCGGCAAGGCGGCCGGTGCCGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN41103.1|4894772_4895510_+|ribonuclease-PH	unknown	unknown	gnl|CDD|178914
CP033073.1|AYN41112.1|4905682_4906285_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	unknown	unknown	gnl|CDD|234648
CP033073.1|AYN41108.1|4903598_4903919_-|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter	unknown	unknown	gnl|CDD|171110
CP033073.1|AYN41113.1|4906311_4907655_-|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
CP033073.1|AYN41102.1|4894443_4894677_+|PTS-sugar-transporter	unknown	unknown	gnl|CDD|238130
CP033073.1|AYN41104.1|4895730_4896138_+|hypothetical-protein	unknown	unknown	gnl|CDD|131391
CP033073.1|AYN41105.1|4896229_4897024_-|DUF1707-domain-containing-protein	unknown	unknown	gnl|CDD|377959
CP033073.1|AYN43811.1|4907851_4909165_+|DUF445-domain-containing-protein	unknown	unknown	gnl|CDD|377281
CP033073.1|AYN43810.1|4897033_4898017_-|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl|CDD|213234
CP033073.1|AYN41098.1|4888378_4889329_+|cysteine-synthase	unknown	unknown	gnl|CDD|273463
CP033073.1|AYN41106.1|4897997_4898789_-|transporter	unknown	unknown	gnl|CDD|253605
CP033073.1|AYN41099.1|4889410_4889860_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN41101.1|4892948_4894259_-|PTS-lactose-transporter-subunit-IIC	unknown	unknown	gnl|CDD|273920
CP033073.1|AYN41110.1|4904495_4904825_-|DUF3618-domain-containing-protein	unknown	unknown	gnl|CDD|378834
CP033073.1|AYN41115.1|4911286_4911589_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN41111.1|4904918_4905386_+|thioredoxin-dependent-thiol-peroxidase	unknown	unknown	gnl|CDD|224146
CP033073.1|AYN41114.1|4909325_4910801_+|MFS-transporter	unknown	unknown	gnl|CDD|340874
CP033073.1|AYN41109.1|4904081_4904441_-|co-chaperone-GroES	unknown	unknown	gnl|CDD|197951
CP033073.1|AYN41100.1|4889950_4890409_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl|CDD|367091
CP033073.1|AYN41107.1|4900773_4903596_+|penicillin-binding-protein	unknown	unknown	gnl|CDD|223815

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN41103.1|4894772_4895510_+|ribonuclease-PH	gnl|CDD|178914	PRK00173, rph, ribonuclease PH; Reviewed.	6.51994e-169
CP033073.1|AYN41112.1|4905682_4906285_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase	gnl|CDD|234648	PRK00120, PRK00120, dITP/XTP pyrophosphatase; Reviewed.	6.90399e-101
CP033073.1|AYN41108.1|4903598_4903919_-|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter	gnl|CDD|171110	PRK11431, PRK11431, quaternary ammonium compound efflux SMR transporter SugE.	8.90113e-28
CP033073.1|AYN41113.1|4906311_4907655_-|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.26234e-80
CP033073.1|AYN41102.1|4894443_4894677_+|PTS-sugar-transporter	gnl|CDD|238130	cd00212, PTS_IIB_glc, PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.	1.15848e-23
CP033073.1|AYN41104.1|4895730_4896138_+|hypothetical-protein	gnl|CDD|131391	TIGR02338, Prefoldin_subunit_beta, prefoldin, beta subunit, archaeal. Chaperonins are cytosolic, ATP-dependent molecular chaperones, with a conserved toroidal architecture, that assist in the folding of nascent and/or denatured polypeptide chains. The group I chaperonin system consists of GroEL and GroES, and is found (usually) in bacteria and organelles of bacterial origin. The group II chaperonin system, called the thermosome in Archaea and TRiC or CCT in the Eukaryota, is structurally similar but only distantly related. Prefoldin, also called GimC, is a complex in Archaea and Eukaryota, that works with group II chaperonins. Members of this protein family are the archaeal clade of the beta class of prefoldin subunit. Closely related, but outside the scope of this family are the eukaryotic beta-class prefoldin subunits, Gim-1,3,4 and 6. The alpha class prefoldin subunits are more distantly related.	0.0014364
CP033073.1|AYN41105.1|4896229_4897024_-|DUF1707-domain-containing-protein	gnl|CDD|377959	pfam08044, DUF1707, Domain of unknown function (DUF1707). This domain is found in a variety of Actinomycetales proteins. All of the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function of this domain.	1.87215e-19
CP033073.1|AYN43811.1|4907851_4909165_+|DUF445-domain-containing-protein	gnl|CDD|377281	pfam04286, DUF445, Protein of unknown function (DUF445). Predicted to be a membrane protein.	1.91674e-129
CP033073.1|AYN43810.1|4897033_4898017_-|ATP-binding-cassette-domain-containing-protein	gnl|CDD|213234	cd03267, ABC_NatA_like, ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA. NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.	2.23399e-126
CP033073.1|AYN41098.1|4888378_4889329_+|cysteine-synthase	gnl|CDD|273463	TIGR01136, Cysteine_synthase, cysteine synthase. This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family].	5.75749e-139
CP033073.1|AYN41106.1|4897997_4898789_-|transporter	gnl|CDD|253605	pfam06182, ABC2_membrane_6, ABC-2 family transporter protein. This family acts as the transmembrane domain (TMD) of ABC transporters. The family includes proteins responsible for the transport of herbicides.	1.21044e-61
CP033073.1|AYN41101.1|4892948_4894259_-|PTS-lactose-transporter-subunit-IIC	gnl|CDD|273920	TIGR01998, N-acetylglucosamine_and_glucose_PTS, PTS system, N-acetylglucosamine-specific IIBC component. This model represents the combined B and C domains of the PTS transport system enzyme II specific for N-acetylglucosamine transport. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name "PTS system, N-acetylglucosamine-specific IIABC component". This family is most closely related to the glucose-specific PTS enzymes. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	1.43437e-122
CP033073.1|AYN41110.1|4904495_4904825_-|DUF3618-domain-containing-protein	gnl|CDD|378834	pfam12277, DUF3618, Protein of unknown function (DUF3618). This domain family is found in bacteria, and is approximately 50 amino acids in length.	1.25013e-08
CP033073.1|AYN41111.1|4904918_4905386_+|thioredoxin-dependent-thiol-peroxidase	gnl|CDD|224146	COG1225, Bcp, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	9.43466e-70
CP033073.1|AYN41114.1|4909325_4910801_+|MFS-transporter	gnl|CDD|340874	cd17316, MFS_SV2_like, Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily. This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.79545e-32
CP033073.1|AYN41109.1|4904081_4904441_-|co-chaperone-GroES	gnl|CDD|197951	smart00883, Cpn10, Chaperonin 10 Kd subunit. The chaperonins are 'helper' molecules required for correct folding and subsequent assembly of some proteins. These are required for normal cell growth, and are stress-induced, acting to stabilise or protect disassembled polypeptides under heat-shock conditions. Type I chaperonins present in eubacteria, mitochondria and chloroplasts require the concerted action of 2 proteins, chaperonin 60 (cpn60) and chaperonin 10 (cpn10). The 10 kDa chaperonin (cpn10 - or groES in bacteria) exists as a ring-shaped oligomer of between six to eight identical subunits, while the 60 kDa chaperonin (cpn60 - or groEL in bacteria) forms a structure comprising 2 stacked rings, each ring containing 7 identical subunits. These ring structures assemble by self-stimulation in the presence of Mg2+-ATP. The central cavity of the cylindrical cpn60 tetradecamer provides as isolated environment for protein folding whilst cpn-10 binds to cpn-60 and synchronizes the release of the folded protein in an Mg2+-ATP dependent manner. The binding of cpn10 to cpn60 inhibits the weak ATPase activity of cpn60.	1.36229e-27
CP033073.1|AYN41100.1|4889950_4890409_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl|CDD|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	1.7195e-05
CP033073.1|AYN41107.1|4900773_4903596_+|penicillin-binding-protein	gnl|CDD|223815	COG0744, MrcB, Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane].	7.76483e-135

Protein sequences

>CP033073.1|AYN41106.1|4897997_4898789_-|transporter
MRAYRLVAGMWVRSTMAYRASFAMTTFGNFAATFFDFVTIMLMFSRVDTLGGYSLPEVAFLYGLSATSFGLADLVIGSMDRLGRRVRDGTLDTLLVRPAPVLAQVAADRFALRRLGRVTQGALVLGWSLTRLDIAWTVPKVLLLPVTVVSGFGIFAAVFVAGAAFQFLAQDASEVQNAFTYGGTTLLQYPPTVFAKELVRGVTFVLPLAFVNWLPACYVLGRPYPLDLPEWAAFTPPLVAVGCCAAAGLAWRAGLRSYRGTGS
>CP033073.1|AYN43810.1|4897033_4898017_-|ATP-binding-cassette-domain-containing-protein
MAAQGVSVNDFIALEKVEKVFEVRRKAGFLKRERHEVRAVDSISFTVARGEMVGYIGPNGAGKSTTIKMLTGILTPSAGRLRVAGIDPARERVRLAHRIGVVFGQRTTLWWDLPLADSYRLAHRMYRIPDARYRQNLDRLVELLDLGALLDVPVRQLSLGQRMRGDIAAALLHDPEVLYLDEPTIGLDVVSKARVREFLREVNAERGTTVLLTTHDLQDIEQLCSRVMVIDHGRLVHDGSLAGLHEAGESERTLVVDLERELPPVEVASARVVRVEGPRQWLAFPAGRSAAPLVADLAARYPLVDLSVREPDIEAVIARMYAERAVS
>CP033073.1|AYN41105.1|4896229_4897024_-|DUF1707-domain-containing-protein
MSDDAAPDLRASDADRERVAEILRDALAEGRLVMEEFEERLEAACTARTYGELAPLTRDLPGAGAVAPAPVSFTKAPVGDGGWADRITGGAGSSAWAVALLSGFERKGRWTVPRRFNCFALLGGGVIDLRDADFAEREVEIFCVAVMGGLQVVVPPGVEVDVRGIGVMGTFAHPPGDVPSAPGAPRVVVGGFAFWGGVGVERKLSRAQRQRLKERRRQEKLERRESRHELRRARRAERHALDPARRIGRRDEQRERQRYRGGER
>CP033073.1|AYN41104.1|4895730_4896138_+|hypothetical-protein
MAASRRSRRHRVTAIAAAVAAAALTAGLTTGCDAVNKALDCVQTADAIADNVTDLQQAVENAADDPSQTDASLDSIEKSLRKIGDKTDDTDVNKAVDDLNQAIGNVRAAIRDGDDTPDVGPVTDAAGELTKVCTS
>CP033073.1|AYN41103.1|4894772_4895510_+|ribonuclease-PH
MSRIDGRTPEQLRPVTIERGWSKHAEGSVLVSFGDTRVLCTASVTEGVPRWRKGSGEGWVTAEYAMLPRATNTRGDRESVKGRIGGRTHEISRLIGRSLRAVIDYKALGENTVVLDCDVLQADGGTRTAAITGAYVALADAVAWAQGRKLVKAGRKPLTGTVSAVSVGIVGGVPLLDLCYEEDVRAETDMNVVCTGDGRFVEVQGTAEAQPFARAELDALLDLAVAGCADLTALQQAALERTRES
>CP033073.1|AYN41102.1|4894443_4894677_+|PTS-sugar-transporter
MASKAEKIVAGLGGIDNIEEIEGCITRLRTEVSDPSLVDDTALKAAGAHGVVRMGTAIQVVIGTDADPLAAEIEDMM
>CP033073.1|AYN41101.1|4892948_4894259_-|PTS-lactose-transporter-subunit-IIC
MSAESAAGPARVHFNRLFQGLQKMGRSLQLPIAVLPAAGILNRLGQPDVFGDQGLGWTGVSKVMKGAGGALLDGSLGLPLLFCVGVAIGMAKKSDGSTALAAVAGFLVYYNVLHQFPGRCPGGSTSVPDVGCQVSVGAGAGAVTPFTFQNPGVFGGIVMGLLAAFFWARYHRTRLVDWLGFFNGRRLVPIIMAFVAIAFAALCLWVWPPVGDALESFAHWLRDLGARGAGLFGLANRALLVIGLHQFLNVPVWFQFGTYTPPGGKPVHGDINMFLAGDPHAGQFTTGFFPIMMFALPAAALAITHCARPERRKEVGGLMLSVALTSFVTGITEPLEYSFLFVAPALYAVHAVLTGVCLGASWALGVHDGFSFSAGLIDYVINWNLATKPWAIIPIGLAFAAVYYAVFRFAITRFDLRTPGREPAEVAQEMDRDNVR
>CP033073.1|AYN41100.1|4889950_4890409_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MDTSWWLALAAVVLLALVATLVDGWGRGRRPGGRRLRPPGRPGTRTARAARPSPGDIWWADVPYEDRAAVKDRPCLVLAVRGDRATVAKITSKYHDERSGVIPLPPGAVGDARGRPSFLETDELREVPVGDFRRRVGVVDPVLWDQVRHLAG
>CP033073.1|AYN41099.1|4889410_4889860_+|hypothetical-protein
MRRTTPLALAAAALLLAGCGSQQEDTGSGGKASEPPSPTRSAGGCTGQADLTAADHGRTVCVTEGGEVRLTLDGTRARPWKAVTASGTGLRGINAGFVLRPGDATAAYRAVAAGTVRLTSSRPLCAEPTAPDRVSCKGVEEWTVTVRVG
>CP033073.1|AYN41098.1|4888378_4889329_+|cysteine-synthase
MRYDSPLAAVGNTPLVRLPRLSPSSDVRIWAKLEDRNPTGSVKDRPALHMIEQAEKDGRLTPGCTVLEPTSGNTGISLAMAAKLKGYRMVCVMPENTSRERRDLLGMWGAEIISSPAAGGSNTAVRVAKELAAEHPDWVMLYQYGNPDNAGAHYATTGPEILADLPSITHFVAGLGTTGTLMGVGRFLREHKPDVKIVAAEPRYDDLVYGLRNLDEGFVPELYDASVLTTRFSVGSADAVTRTRELLQQEGIFAGVSTGAALHAAIGVGRKAVQAGESADIVFVVADGGWKYLSTGVYTAATTEEAIETLQGQLWA
>CP033073.1|AYN41107.1|4900773_4903596_+|penicillin-binding-protein
MLRRVGAPRSGEPGDAGASSAGKQDPAGRTPRASVPRPAGRNSGTGPAAKSAGATAAVAATGAAAASSPAAARAARAARAAGAAGAAAGAVAGAASAAGAAAQASPAGAGAAARPGSSEAETTALAATDGPAGGGSDSGKGKGKAADGGGKGKRPRRTGLRRLLPTWRMVLGTFVVGVLLVVGLFFVGYSLVQIPSANAFATKQANVYLYADGSQIARDTRDSQVNRENVGLAEISKDAQHAALAAEDRDFYTESAVDLKAMLRAGWNTATGKGKQSGSTITQQYVKNYYLGQEQTVTRKAKEFFISIKLDREKSKNEILEGYLNTSYFGRGAYGIQAAAQAYYGRDAADLDPARAAYLAALVNAPSEYDVVAHPENRKAAVARWNYVLDGMVKKGWLSQGERAGAKFPMPKQQILSTGLSGQRGYLVDAVRHYLITNKIVTADQLQAGGYRITTTIQKKKQDAFVKAVDDQLMSKLDKENRKADTYVRAGGASVDPKTGEVVAMYGGVDYVKQYTNGATRGDFQVGSTFKPFVFTSAVENGSTTQDGRTITPNTIYDGTNKRLVQGWSGAPYNPENEDQKSYGPITVGKATDLSVNSVYAQMAADVGPAKVKQTAVDLGIPAGTPDLYPSPSMALGTANASVLDMAEAYATLANHGKHGTYTLVQKITKDGTEPMELPGRPARQAVSREAADTTTSVLRSVVESGTATAAQNAGRPAAGKTGTAESDTAAWFAGYTPDLATVVSVMGQDPVTAKHMPLYGALGVNRMNGGGPPTQIWAQYTRDALKGKPAGAFDLQLQTGADQPQAPGTTAPTQPGTDAGQGTGGTATDGGTAGGGATATPTDGGTTGTPTDGGTATDGGTPTDGGTATGGGTTTTTGTGGDTTGGDGTTTDGGVPTGGGTTGGGGPTTGGGGTAGGGTQGGNTTGTDTGTGTGGFPGT
>CP033073.1|AYN41108.1|4903598_4903919_-|QacE-family-quaternary-ammonium-compound-efflux-SMR-transporter
MAWVLLVVAGLLEVGWSVGMKYSEGFTRPVPSLFTGAGIVASMILLSYAARSLPIGTAYGVWVGIGAAGAAVLGMVVLGEPVTAARVFFVCLLLVAVVGLKATGGH
>CP033073.1|AYN41109.1|4904081_4904441_-|co-chaperone-GroES
MSANRNEHSTPHHDKLPIRMLHDRVLVRQETGEGERRSGGGILIPATAAVGRRLAWAEVVAVGQNVRTVEPGDRVLFDPEDRAEVEVRGVAYVLMRERDLHAVAADRFEGSEDSTGLYL
>CP033073.1|AYN41110.1|4904495_4904825_-|DUF3618-domain-containing-protein
MADTSDTRTPAQIEAAIRRRREVLAETLDEIGVRVHPKTIVGDAKAKVVANVDHTVGRAYVQVNRVVSELRGQFVDEEGAPRPERVVPAALVVVGVVGLLALASRRRRG
>CP033073.1|AYN41111.1|4904918_4905386_+|thioredoxin-dependent-thiol-peroxidase
MSERLQPGDVAPAFTLPDADGNDVSLSDHEGRKVIVYFYPAALTPGCTKQACDFTDNLQLLADAGYDVIGVSPDEPEKLAKFREKESLRITLLADPDKRVTEAYGAYGEKKNYGKTYLGVIRSTVIVDEQGKVERALYNVRATGHVAKIIKDLGI
>CP033073.1|AYN41112.1|4905682_4906285_-|RdgB/HAM1-family-non-canonical-purine-NTP-pyrophosphatase
MTRLILATRNAGKITELRAILAEAGLPHGLTGADAYPDIPDVRETGVTFAENALLKAHALARATGLPAVADDSGLCVDVLGGAPGIFSARWAGRHGDDRANLELLLAQLSDIADEHRGAHFACAAALALPDGTERVVEGRLRGVLRHAPAGTNGFGYDPILQPEDETRTCAELSPREKNAISHRGKAFRALVPVVRELVG
>CP033073.1|AYN41113.1|4906311_4907655_-|SGNH/GDSL-hydrolase-family-protein
MTKRHGYAVLCALVALVAALSAAIYVTVAADDGTAGTVRGTLADSRPHRDSAAAPASTGTWVGAWATAPVGGEPGTEAAGMAGRSVRNVVHTATGGTSARITLSNLYGQSPLTLTHATIALSAGDGTAAADATTMRRLTFDGGTGVVVPAGGQTVSDAVRLTIPRGSDVLVTTYSPTASGPVTYHPHARQTSFVADGERAEDVTGAPYTQQTPYWRYLTALDVLSNEADGTVVVFGDSITDGITSTTGANHRWPDILAGRLRGALEGGRQLPRYSVVNEGISGNQVLADGLGRPAENQSGLGRFGRDTLSRTNARAVVIDLGVNDILRNRELADPDRIVTGLRTLVRQAHARGLKAVGATLMPFRGHRGFTPAREAVRQQVNARIRAGGVYDAVVDFDRALRDPYDPRRLRAEYDSGDHLHPGDLGFARMAEVFDLRTLRGAGQTEL
>CP033073.1|AYN43811.1|4907851_4909165_+|DUF445-domain-containing-protein
MEPTETGTQGRGTSYRTMTAFTPADEERRRGVRRMKLTAAGLLLLVAVVYVLAKVAGHAGAGTWTGYVAAAAEAGMVGALADWFAVTALFRHPLGLPIPHTAIIPNKKDQLGVSLGEFVGENFLSEDVVRQRLRAVGIGGRLGTWLAEPEHADRVTAELATALRGALTVLRDSDVQAVVGEAITRRADAREIAPRLGTMLEKVVADGGHRRVVDLVVTRAHDWLVLHRDDVMVAVEGGAPGWTPRFVDRKVGERVYKELLRFVIEMRDMPSHPARGALDRFLTDFAADLQSDTDTRARVERLKTEVLGRGEVQELIASAWTAVRSMIVAAADDERSELRLRVRAALLSLGTRMATESKVQGKVDSWVEGAAVHVVTTYRKEITSLITDTVAGWDAEHTTRKIEAHIGRDLQFIRINGTVVGSLAGLLIYTVSRGLGA
>CP033073.1|AYN41114.1|4909325_4910801_+|MFS-transporter
MSTAQAERGRTITTDIPARLDRLPWSRWHWTIVIGLGTVWILDGLEVTVVGNIASRLSEPGSGLSISSGQVTGTAAALYVAGACVGALFWGRLTDRFGRKNLFMITLAVYLAATAMTAVSWEAWWFFLFRFLTGFGIGGEYAAINSAIDELIPANYRGRVDLIINGSFWLGAVGGSLLSIVALDTDLLAADVGWRLTFALGTVLALVILLVRRHVPESPRWLLIHGRDREAEDIVTGIERRVEAEKGERLPRPEGELEIRQRKNVTFLEIARTVFGQYRKRAVLGFSLFVGQAFLYNAITFGFGAILTKFYDVPADRTGYYFAVIAIGNFCGPLLLGRFFDTVGRRVMISSTYILSGLLLFGTAWLFGRGSLSAVTLTACWCAVLFFASAGASSAYLTVSEIFPMETRAMSIAFFYALGTAAGGISGPLLFADLTNTGRVGDTVLAFSIGAGLMCAAGLVAAALAVRAERRSLEDVARPLTAVTGRAKTAA
>CP033073.1|AYN41115.1|4911286_4911589_-|hypothetical-protein
MARVPSAVVAATGLVGGYGVARWTKKRQLGGVVLTVAGAAAARQWQRQAGGTAAGALTAAYVAAFAGSHPLAKKVGAWPSVLGVAGAVALTSWAVADRKA

Crispr_ID: CP033073_14

• CRISPR_ID: CP033073_14
• CRISPR_location: 6123928-6124008
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: DEDDh

Consensus repeat of CP033073_14

Consensus_repeat	Method
TGACGGCGTCCCCGGCTCCCGACG	CRISPRCasFinder

spacers of CP033073_14

>14.1|6123952|33|CP033073|CRISPRCasFinder
ACGCCCCCGACCCCTGACGGCGCCCCGGGCCTC

CRISPR arrays and Neighbor proteins around CP033073_14

CRISPR arrays

The CRISPR arrays of CP033073_14

>merge|CP033073|14|6123928-6124008|CRISPRCasFinder
TGACGGCGTCCCCGGCTCCCGACGACGCCCCCGACCCCTGACGGCGCCCCGGGCCTCTGACGGCGTCCCCGGCCCCCGACG

>CP033073|14|14|6123928-6124008|CRISPRCasFinder
TGACGGCGTCCCCGGCTCCCGACG	ACGCCCCCGACCCCTGACGGCGCCCCGGGCCTC
TGACGGCGTCCCCGGCCCCCGACG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN42040.1|6127728_6129384_+|cation-acetate-symporter	unknown	unknown	gnl|CDD|271374
CP033073.1|AYN42041.1|6130587_6131232_-|NADP-oxidoreductase	unknown	unknown	gnl|CDD|224996
CP033073.1|AYN43911.1|6129475_6130546_+|GTP-3',8-cyclase-MoaA	unknown	unknown	gnl|CDD|234672
CP033073.1|AYN42027.1|6113348_6114014_+|hypothetical-protein	unknown	unknown	gnl|CDD|379140
CP033073.1|AYN43910.1|6116039_6116300_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42028.1|6114144_6115743_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|223562
CP033073.1|AYN42044.1|6133230_6133467_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42030.1|6117464_6118220_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187602
CP033073.1|AYN42043.1|6132241_6133174_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176149
CP033073.1|AYN42033.1|6121027_6121261_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42032.1|6120180_6120978_-|SURF1-family-protein	unknown	unknown	gnl|CDD|119401
CP033073.1|AYN42036.1|6124073_6125450_-|hypothetical-protein	unknown	unknown	gnl|CDD|367110
CP033073.1|AYN42034.1|6121388_6122372_-|DEDDh-family-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	gnl|CDD|180377
CP033073.1|AYN42039.1|6127375_6127732_+|DUF485-domain-containing-protein	unknown	unknown	gnl|CDD|377315
CP033073.1|AYN42037.1|6125521_6127027_-|peptidase-S8	unknown	unknown	gnl|CDD|173799
CP033073.1|AYN42031.1|6118225_6120016_-|glycoside-hydrolase-family-15-protein	unknown	unknown	gnl|CDD|225922
CP033073.1|AYN42038.1|6127018_6127219_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42029.1|6116417_6117221_+|enoyl-CoA-hydratase/isomerase-family-protein	unknown	unknown	gnl|CDD|119339
CP033073.1|AYN42042.1|6131309_6132122_-|3'(2'),5'-bisphosphate-nucleotidase-CysQ	unknown	unknown	gnl|CDD|238816
CP033073.1|AYN42035.1|6123002_6123713_+|VIT-family-protein	unknown	unknown	gnl|CDD|153123

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP033073.1|AYN42034.1|6121388_6122372_-|DEDDh-family-exonuclease	DEDDh	cd06127_DEDDh_CAS-I	1.2e-40	134.0	0.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN42040.1|6127728_6129384_+|cation-acetate-symporter	gnl|CDD|271374	cd11480, SLC5sbd_u4, Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain. SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.	0
CP033073.1|AYN42027.1|6113348_6114014_+|hypothetical-protein	gnl|CDD|379140	pfam13360, PQQ_2, PQQ-like domain. This domain contains several repeats of the PQQ repeat.	0.00186103
CP033073.1|AYN43911.1|6129475_6130546_+|GTP-3',8-cyclase-MoaA	gnl|CDD|234672	PRK00164, moaA, GTP 3',8-cyclase MoaA.	0
CP033073.1|AYN42028.1|6114144_6115743_+|ABC-transporter-ATP-binding-protein	gnl|CDD|223562	COG0488, Uup, ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only].	2.62899e-174
CP033073.1|AYN42030.1|6117464_6118220_-|SDR-family-oxidoreductase	gnl|CDD|187602	cd05344, BKR_like_SDR_like, putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR. This subgroup resembles the SDR family, but does not have a perfect match to the NAD-binding motif or the catalytic tetrad characteristic of the SDRs. It includes the SDRs, Q9HYA2 from Pseudomonas aeruginosa PAO1 and APE0912 from Aeropyrum pernix K1. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	5.5262e-68
CP033073.1|AYN42043.1|6132241_6133174_+|LysR-family-transcriptional-regulator	gnl|CDD|176149	cd08460, PBP2_DntR_like_1, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold. This CD includes an uncharacterized LysR-type transcriptional regulator similar to DntR, NahR, and LinR, which are involved in the degradation of aromatic compounds. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.85642e-79
CP033073.1|AYN42032.1|6120180_6120978_-|SURF1-family-protein	gnl|CDD|119401	cd06662, SURF1, SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.	1.5856e-44
CP033073.1|AYN42036.1|6124073_6125450_-|hypothetical-protein	gnl|CDD|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	1.50787e-40
CP033073.1|AYN42034.1|6121388_6122372_-|DEDDh-family-exonuclease	gnl|CDD|180377	PRK06063, PRK06063, DEDDh family exonuclease.	4.17586e-168
CP033073.1|AYN42039.1|6127375_6127732_+|DUF485-domain-containing-protein	gnl|CDD|377315	pfam04341, DUF485, Protein of unknown function, DUF485. This family includes several putative integral membrane proteins.	2.8493e-33
CP033073.1|AYN42037.1|6125521_6127027_-|peptidase-S8	gnl|CDD|173799	cd07473, Peptidases_S8_Subtilisin_like, Peptidase S8 family domain in Subtilisin-like proteins. This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values.	3.26045e-57
CP033073.1|AYN42031.1|6118225_6120016_-|glycoside-hydrolase-family-15-protein	gnl|CDD|225922	COG3387, SGA1, Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism].	2.82928e-130
CP033073.1|AYN42041.1|6130587_6131232_-|NADP-oxidoreductase	gnl|CDD|224996	COG2085, COG2085, Predicted dinucleotide-binding enzymes [General function prediction only].	1.64554e-28
CP033073.1|AYN42029.1|6116417_6117221_+|enoyl-CoA-hydratase/isomerase-family-protein	gnl|CDD|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	4.93779e-53
CP033073.1|AYN42042.1|6131309_6132122_-|3'(2'),5'-bisphosphate-nucleotidase-CysQ	gnl|CDD|238816	cd01638, CysQ, CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine biosynthesis (a principal route of sulfur assimilation).	2.93517e-39
CP033073.1|AYN42035.1|6123002_6123713_+|VIT-family-protein	gnl|CDD|153123	cd02432, Nodulin-21_like_1, Nodulin-21 and CCC1-related protein family. Nodulin-21_like_1: This is a family of proteins closely related to nodulin-21, a plant nodule-specific protein that may be involved in symbiotic nitrogen fixation. This family is also related to CCC1, a yeast vacuole transmembrane protein that functions as an iron and manganese transporter. .	3.15091e-100

Protein sequences

>CP033073.1|AYN42035.1|6123002_6123713_+|VIT-family-protein
MTEPTHDETHGGALGSRLNWLRAAVLGANDGIVSTAGLVVGVAGATGSRAALLTAGLAGLLAGSMSMAAGEYVSVSTQRDSEMAALAVERRELREQPEAELEELTELLEGRGLSRQVAREAAEQLTARDALRAHARVELGIDPDELTNPWHAAWASFLAFTVGALLPLLAIVLPPAGQRLPVTVACVLAALVLTGWSSARLGAADPGRAVLRNVAGGVLAMGVTYAAGSLLGAAGV
>CP033073.1|AYN42034.1|6121388_6122372_-|DEDDh-family-exonuclease
MLEDHATAVSSPTPWPAAYPRGYAVVDVETTGLARDDRIISAAVYRLDWRGEVEDHWYTLVNPERDPGPVWIHGLTSDVLAGAPLFGDIAEEFAARLDGRVLVAHNAVFDWQMIAREYARVRREAPVRQRLCTIALSKELALPLPNHKLESLAAHFGVVQQRAHHALDDARVLAEAFRPSLRAAAAGGVRLPLLECRPLTEWADRSVPRQATGGYGGYPSGSWRPSRKRPACPHPNPGRYEEGKSLKQGMRVAFSGDTSTERELLEDRAVEAGLHVATSISRLTSLLVTNDPDSGTSKTVKARQYGTPVVDEAAFGQLLGDVEPADG
>CP033073.1|AYN42033.1|6121027_6121261_-|hypothetical-protein
MATCEVCGNDYGMTFEVHAQGAVHVFDCFSCAIHRMAPICEHCRVQIIGQGVEVEGHWFCGAHCARAEGNAGIVDRV
>CP033073.1|AYN42032.1|6120180_6120978_-|SURF1-family-protein
MHRYRFLLSRQWVILTLVAIALIPTMIKLGFWQQHRYQERTARNDLVSAALHAEPVPVERLTSPGHTVTRTEKYRTVTATGTFDTARQVVVRRRTSSDGEVGFHVLTPLVLTDGMVLLVNRGWIPANGAQTAFPKIPAPPAGRTTVTGRLKADETTAASGIKNVEGLPDRQIMLINSAEEAHRLGARVLGGYVEQTAPAAKGGSPEQISDPGSEDAPLNYAYMIQWWLFAAAVPVGWWFLVRREIRDREETAAERKPEESEPATV
>CP033073.1|AYN42031.1|6118225_6120016_-|glycoside-hydrolase-family-15-protein
MNPRIEDYALIGDEQSAALIGRDGSVDWLCLPRFDSGACFARLLGDENHGHWRIAPEGTDTCTRRAYRSDTLVLDTEWETSDGTVRVTDLMPQRGRAPDVVRIVEGISGRVTVRSTLRLRFDYGSVMPWMRRADGHRVAVAGPDSAWLRTEPAVDTWGEDHATHARFTVEEGERIAFVLTWHPSHEKRPPLIDPYEALEHSVTDWRRWARRCRYDGPHRDAVVRSLITLKALTYAPTGGIVAAATTSLPEQPGGVRNWDYRYCWLRDSTLTLGALLTAGYQEEAEAWRDWLLRAVAGDPADLQIMYGVAGERRLPETELPWLPGFADSAPVRTGNGAVDQLQLDVYGEVMDSLSLARGSGLPTKPHMWAMQRALLRYLETAWRQPDEGLWEVRGGRRHFVHSKVMVWVAFDRAVRTMERHPRLGGDLEGWRALRDEVHREVCEKGFDRERNTFTQYYGSRGLDAALLLIPRVGFLPPDDPRVVGTVDAIRDDLGHGGFLRRYDTRDAGSEIDGLPGAEGTFVACSFWLADALHRTGRTEEARELFDRLVGLCNDVGLLAEEYDPVDGRLLGNYPQAFSHIGLVNTALTLFGDDEAG
>CP033073.1|AYN42030.1|6117464_6118220_-|SDR-family-oxidoreductase
MDLGLKDRVFVVTGATRGLGNAAARELVADGAKVVITGRDGQRVADAAAALGPNAVGVAVDNADPEAAERLIAAAREHFGGFHGVLVSVGGPAPGFVADNTDEQWRGAFESVFLGAVRVARAAAAELTAGGVIGFVLSGSVYEPIPGLTISNGLRPGLAGFAKSLADELGPRGIRVVGVLPSRIDTDRVRELDALSADPEATRAANESRIPLRRYGTPQEFGKVAAFLLSPAASYLTGLMVPVDGGMLHGF
>CP033073.1|AYN42029.1|6116417_6117221_+|enoyl-CoA-hydratase/isomerase-family-protein
MASPDQDLAPVLDKDGVRLTVDDTLATVTLTNPAKRNAQSPALWRALAEAGQRLPGSVRVVVLRGEGKSFSAGLDRQMFTPEGIPGEPSFMDLARRDDAGLDATIAEYQEAFTWWRRNDIVSIAAVQGHAIGAGFQLALGCDLRVVADDVQFAMRETSLGLVPDLAGTHPLVSLVGYGRALEICVTGRFVGAEEAVTSGLASLAVPASELDAAARDLAAAVLAAPRDAVVETKALVRGARDRDYDTQRAAERAAQTRRLRDLAGLGE
>CP033073.1|AYN43910.1|6116039_6116300_+|hypothetical-protein
MRRPERTSHEEARVAETLKKGSRVTGAARDKLAADLKKKYDSGASIRALAEETGRSYGFVHRMLSESGVTLRGRGGATRGKKAATS
>CP033073.1|AYN42028.1|6114144_6115743_+|ABC-transporter-ATP-binding-protein
MISASGIELRAGARVLLENASFRVAKGDRIGLVGRNGAGKTTLTKCLAGEGVPAGGTITRSGEVGYLPQDPRTGDLDVLARDRILSARGLDILIRKMRDNEQRIANGQGATREKALRQYERQETEFLTKGGYSAEAEAATIAAALNLPDRVLGQPLHTLSGGQRRRIELARILFSDADTLLLDEPTNHLDADSIVWLRDYLKTYRGGFIVISHDVDLVETVVNKVFYLDANRSQIDVYNMGWKLYQQQREADEKRRKRERANAEKKAAALHTQADKMRAKATKTVAAQNMARRADKLLSGLEAVRQSDKVAKLRFPDPSPCGRTPLMAEGLSKSYGSLEIFTDVDLAIDRGSRVVILGLNGAGKTTLLRLLAGAERPDTGQVVPGHGLKLGYYAQEHETLDPDRTVLENMRSAAPDLDLVEVRKVLGSFLFSGDDVDKPAGVLSGGEKTRLALATLVVSSANVLLLDEPTNNLDPASREEILGALRTYKGAVVLVTHDEGAVEALQPERIILLPDGVEDLWGADYADLVALA
>CP033073.1|AYN42027.1|6113348_6114014_+|hypothetical-protein
MAPYVRRACGLLLAFGLLAAAHHLRPAPYGDRLTTSARVAGQPRGGPWTPSARGSAVAARDARTGAVRWRYARAGHRPAAVLPARGEVIALWDDGLLTDTDGRSVRWHRALPDAAEWLPAQGGTGVLRPLGPDVLAVVTPHRVTAYRIADGDLRWVLPAHEGCVFRSRGAVRRGAALLLAQPCAHTAWTGQLVALDDQGRITPGRDPLGNGLPRRGPRART
>CP033073.1|AYN42036.1|6124073_6125450_-|hypothetical-protein
MTEIMYAWSAVGGDPARLARLTTVAREGVLPARLPVRQLARACVGACGLAAAELAARRAGLGEVPGVRVDDGAVAAAFHSERHLRVDGRAPVLFSPLSRFWRTADGWVRTHANYPHHRARLLTALDLPRDAPAEKAAARLAALSALEAEEAVCGAGGLAVALRTPAQWQAHEQAAEVALRPLVEREQLDAAPARVLAPLDPAGAPLLPAAGLRVLDLTRVLAGPVATRTLALLGADVLRVDAPWLPELPDQHADTGFGKRSAVLDLAAGRDTFEDLLSAADVVVSGYRPGALDRFGLSPRELVARRPGLVVAQVSAWGAYGPWGGRRGFDSLVQAATGIAVTEGPAGEPGALPAQALDHGTGYLLAAAVLRALTEQSYEGGSRLVRLALARTAHWLTSGIGPAPAEGTPYPGPEAWLTGTDSPLGRLRHARPAVSFTGGPTDWARPPGPWGSDPARWR
>CP033073.1|AYN42037.1|6125521_6127027_-|peptidase-S8
MAHLRSGRRLALAVPVVLSLTASLGLLPSAASAAPAADGPVLSYVVNVGPGHGVAHRVRKAIAEAGGSVVIAYDRIGVIVVHSANPAFAEAVRTVPGVDSAGATRNAPLPAQSTTDVGTPKVLGAGEAAAAGARAADGQDPLEPLQWDLPAIKADKAHEKTLGSRKVTVAVIDTGVDDTHPDIAPNFDREASADCVSGRPDTTDGAWRPSASESPHGTHVAGEIAAAKNGVGVTGVAPGVRVAGIKVGNPDGYFYTEAVVCGFVWAAEHHVDVTNNSYYTDPWYFNCTTDPDQRALVDAVARASRYAEEQGAVNVAAAGNERYDLASHAITDPVSPNDGTPAERVIDPHACYDIPTQLPGVVTVAATGAKGLKSSFSNYGLGVIDIAAPGGDSTAYQAPRPPATSGLVLGPLPGGKWGYMAGTSMATPHVAGVAALIKSTHPHASAALVKALLYAEADATPCTDPYDIDGDGKVDAVCEGTRNRNGFYGWGTADALAAVTR
>CP033073.1|AYN42038.1|6127018_6127219_+|hypothetical-protein
MSHGISTSSGYGTAPRHGWCSGRYMTGGAGRSYLPRPVSGRARRDAARKPRTRASPRACARGTEPA
>CP033073.1|AYN42039.1|6127375_6127732_+|DUF485-domain-containing-protein
MATETPPPATPGAPLPSTEEFTEVQQSAEFGELRRAHRSFAFPLTVVFITWYLLYVLLSNYAGGFMGTRVAGNINVALVLGLAQFLTTFLIAWWYARHAATELDPRAEAIKSRMEGGA
>CP033073.1|AYN42040.1|6127728_6129384_+|cation-acetate-symporter
MSPAQHTLSATGRASHTLLAAGEASEHRTLIVTLFAVFVAATLVITVWAGRQTKDAADFYAGGRQFTGFQNGLAVSGDYMSAASFLGIAGAIALFGYDGFLYSIGFLVAWLVALLLVAEPLRNSGRYTMGDVLAYRMRQRPVRTAAGTSTIVVSIFYLLAQMAGAGVLVSLLLGITSDGGKIGIVALVGVLMIVYVTIGGMKGTTWVQMVKAVLLIVGALLLTFLVLLKFHFNVSDLLGKAAANSGKGSAFLEPGLKYGATGTTKLDFLSLGIALVLGTAGLPHILIRFYTVPTARAARKSVLWAIGLIGVFYLMTLALGFGAAALIDPDEITGSNKAGNTAAPLLALHLGGLHSDWGAVLLATISAVAFATILAVVAGLTLASSSSFAHDIYANVIRKGQATEKQEISAARYATVGIGAVSILLGALARDLNVAGLVALAFAVAASANLPTILYSLFWKRFTTSGALWSIYGGLVTAVGLVLFSPVVSGKESSMFPGVDFHWFPLENPGIISIPVGFLLGVVGTLLSKETPDDGKYAELEVRSLTGTGAH
>CP033073.1|AYN43911.1|6129475_6130546_+|GTP-3',8-cyclase-MoaA
MGSRRLAGEQETRCRFATSDPEREGAHVLIDTYGRVATDLRVSLTDRCNLRCTYCMPEEGLQWLAKPDLLTDDEIVRLIGIAVRALGIEEVRFTGGEPLLRPGLTGIVERVAALAPRPRMSLTTNGIGLRRTAAALKAAGLDRVNVSLDTLRPDVFKTLTRRDRHKDVLEGLEAAREAGLTPVKVNSVLMPGLNDDEAPDLLAWAVEHDYELRFIEQMPLDAQHGWKREGMVTAGDILTSLHTRFDLTPEGAQERGSAPAERWLVDGGPHRVGVIASVTRPFCAACDRTRLTADGQIRTCLFATEETDLRAALRSGAPDEEIARLWRLAMWGKKAGAGLDDPSFVQPDRPMSAIGG
>CP033073.1|AYN42041.1|6130587_6131232_-|NADP-oxidoreductase
MTSIGILGAGRVGANLAGKLAAAGHHVVLGRRDPDERTPALTGTTGPRVSFSDQRTTARTTDVVINATPGDSALDRLTGLRAELAGKILVDVSNATRDTGGLPGDLCYPGSSLAERLQAALPDTRVVKTLNTMLYMVMTAPGMLATPPTVYVSGDDASAKTTVTGLLGDLGWQPGWIEDLGDITTARATEAMILVVPHVLRRHGLEPFAVSLAR
>CP033073.1|AYN42042.1|6131309_6132122_-|3'(2'),5'-bisphosphate-nucleotidase-CysQ
MSTTMPFAAGTTLLADVTSLVRTAGRTLLDRRTPHARGVSLDEIVDEIHANDDAVLDVLREPLLRTRPGSRWAEDELAGGALPPGEWWVVDPAEGNINHVHAMEDWAVTATLVRDNQPVLTVVHLPLTGETYTAVAGGGARLDGRPLKVSAKTDLGATLTGTGQARPGEDMRTFRRIGESVTAMLASGLVVRVSVPATMQLIHVAAGRMDAFWQFSDVRSGLVAGALLVSEAGGTVTDLAGEPWSTAGRDFLAAAPGVHTAALEVLSPIA
>CP033073.1|AYN42043.1|6132241_6133174_+|LysR-family-transcriptional-regulator
MQLDLNLLTALDALLEEGSVAGAAARLHVTAPAMSRSLGRIRKATGDQILVRTGRSMVPTPRALAIRSQVHALVQQAHHLLSAQQELDLAALERVFTVRWHDALTTACGTALITAVHRRAPGVQLRLPAESGTDTPELRRGEVDLESSSARPTLPDIRHRLVGRDQLVVAVRPGHPLAEGPPSIERYAAAEHLTVSRRGRLRDPVDDALTARGRERHVVATGPTLAFALQLAPETDLVLTLPDAVTRTARDRLGLITLPLPFQMPAVPLYLLWHQRHDDDRAHTWLRDLATETVRALFEPPPASPQDPTP
>CP033073.1|AYN42044.1|6133230_6133467_-|hypothetical-protein
MSDETPICSAKGCRTAAVWVLAWNNPKIHTPERRKTWLACDEHREHLSEFLGVRGFLKDVVTLEQWQASEDAGPSVAG

Crispr_ID: CP033073_15

• CRISPR_ID: CP033073_15
• CRISPR_location: 6725053-6725152
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP033073_15

Consensus_repeat	Method
GCATCGGGCTCTGCTGTGCCGGGC	CRISPRCasFinder

spacers of CP033073_15

>15.1|6725077|52|CP033073|CRISPRCasFinder
GGCATCGGGCTCTGCTGTGCCGGGCGGCATCCGGATCCCCCTGCGCCGGGCC

CRISPR arrays and Neighbor proteins around CP033073_15

CRISPR arrays

The CRISPR arrays of CP033073_15

>merge|CP033073|15|6725053-6725152|CRISPRCasFinder
GCCCCGGCCCCTGCTGTGCGGAGCGGCATCGGGCTCTGCTGTGCCGGGCGGCATCCGGATCCCCCTGCGCCGGGCCGCATCGGGGTCTGCTGTGCCGGGC

>CP033073|15|15|6725053-6725152|CRISPRCasFinder
GCCCCGGCCCCTGCTGTGCGGAGC	GGCATCGGGCTCTGCTGTGCCGGGCGGCATCCGGATCCCCCTGCGCCGGGCC
GCATCGGGGTCTGCTGTGCCGGGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN42494.1|6729402_6729960_+|hypothetical-protein	unknown	unknown	gnl|CDD|240137
CP033073.1|AYN42497.1|6733126_6733534_-|CoA-binding-protein	unknown	unknown	gnl|CDD|224745
CP033073.1|AYN42488.1|6722081_6722519_+|DUF4442-domain-containing-protein	unknown	unknown	gnl|CDD|373120
CP033073.1|AYN42493.1|6728767_6729340_+|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380339
CP033073.1|AYN42490.1|6726533_6727178_+|DedA-family-protein	unknown	unknown	gnl|CDD|223659
CP033073.1|AYN43958.1|6725252_6726302_-|UPF0104-family-protein	unknown	unknown	gnl|CDD|377103
CP033073.1|AYN43957.1|6711971_6712448_-|transposase	unknown	unknown	gnl|CDD|379282
CP033073.1|AYN42486.1|6720039_6720885_+|spermidine-synthase-like-protein	unknown	unknown	gnl|CDD|223498
CP033073.1|AYN42483.1|6716997_6717564_-|hypothetical-protein	unknown	unknown	gnl|CDD|197226
CP033073.1|AYN42492.1|6727871_6728636_+|acyltransferase	unknown	unknown	gnl|CDD|100053
CP033073.1|AYN42491.1|6727234_6727762_-|gamma-carbonic-anhydrase-family-protein	unknown	unknown	gnl|CDD|100051
CP033073.1|AYN42489.1|6722941_6724957_+|hydrolase	unknown	unknown	gnl|CDD|366226
CP033073.1|AYN42496.1|6731273_6732911_-|APC-family-permease	unknown	unknown	gnl|CDD|223605
CP033073.1|AYN42495.1|6729985_6731206_-|4-hydroxybenzoate-3-monooxygenase	unknown	unknown	gnl|CDD|236198
CP033073.1|AYN42482.1|6712586_6716726_+|hypothetical-protein	unknown	unknown	gnl|CDD|366703
CP033073.1|AYN42484.1|6718067_6718484_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42485.1|6718467_6718695_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42481.1|6711447_6712026_-|IS630-family-transposase	unknown	unknown	gnl|CDD|315923
CP033073.1|AYN43959.1|6733676_6734417_+|hypothetical-protein	unknown	unknown	gnl|CDD|183518
CP033073.1|AYN42487.1|6720924_6721938_-|hypothetical-protein	unknown	unknown	gnl|CDD|370676

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN42494.1|6729402_6729960_+|hypothetical-protein	gnl|CDD|240137	cd04939, PA2301, PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, and ProX. The primary function of INS is to hydrolyze mischarged cysteinyl-tRNA(Pro)'s, thus helping ensure the fidelity of translation. Organisms whose ProRS lacks the INS domain express a single-domain INS homolog such as YbaK, ProX, or PrdX which supplies the function of INS in trans.	2.92193e-71
CP033073.1|AYN42497.1|6733126_6733534_-|CoA-binding-protein	gnl|CDD|224745	COG1832, COG1832, Predicted CoA-binding protein [General function prediction only].	1.7826e-46
CP033073.1|AYN42488.1|6722081_6722519_+|DUF4442-domain-containing-protein	gnl|CDD|373120	pfam14539, DUF4442, Domain of unknown function (DUF4442). This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 139 and 165 amino acids in length. There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	8.08197e-20
CP033073.1|AYN42493.1|6728767_6729340_+|XRE-family-transcriptional-regulator	gnl|CDD|380339	cd02209, cupin_XRE_C, XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain. This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.	3.85767e-19
CP033073.1|AYN42490.1|6726533_6727178_+|DedA-family-protein	gnl|CDD|223659	COG0586, DedA, Uncharacterized membrane-associated protein [Function unknown].	4.64663e-39
CP033073.1|AYN43958.1|6725252_6726302_-|UPF0104-family-protein	gnl|CDD|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	6.62926e-12
CP033073.1|AYN43957.1|6711971_6712448_-|transposase	gnl|CDD|379282	pfam13592, HTH_33, Winged helix-turn helix. This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	7.01447e-17
CP033073.1|AYN42486.1|6720039_6720885_+|spermidine-synthase-like-protein	gnl|CDD|223498	COG0421, SpeE, Spermidine synthase [Amino acid transport and metabolism].	3.95164e-12
CP033073.1|AYN42483.1|6716997_6717564_-|hypothetical-protein	gnl|CDD|197226	cd09128, PLDc_unchar1_2, Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins. Putative catalytic domain, repeat 2, of uncharacterized phospholipase D (PLD, EC 3.1.4.4)-like proteins. PLD enzymes hydrolyze phospholipid phosphodiester bonds to yield phosphatidic acid and a free polar head group. They can also catalyze transphosphatidylation of phospholipids to acceptor alcohols. Members of this subfamily contain two HKD motifs (H-x-K-x(4)-D, where x represents any amino acid residue) that characterizes the PLD superfamily. The two motifs may be part of the active site and may be involved in phosphatidyl group transfer.	0.00861502
CP033073.1|AYN42492.1|6727871_6728636_+|acyltransferase	gnl|CDD|100053	cd04647, LbH_MAT_like, Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively while GAT specifically acetylates galactopyranosides. XAT catalyzes the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and streptogramin, among others. XATs are implicated in inactivating xenobiotics leading to xenobiotic resistance in patients. Members of this family contain a a left-handed parallel beta-helix (LbH) domain with at least 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). They are trimeric in their active form.	8.19431e-43
CP033073.1|AYN42491.1|6727234_6727762_-|gamma-carbonic-anhydrase-family-protein	gnl|CDD|100051	cd04645, LbH_gamma_CA_like, Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Gamma CAs are trimeric enzymes with left-handed parallel beta helix (LbH) structural domain.	1.90259e-80
CP033073.1|AYN42489.1|6722941_6724957_+|hydrolase	gnl|CDD|366226	pfam00652, Ricin_B_lectin, Ricin-type beta-trefoil lectin domain.	8.31693e-22
CP033073.1|AYN43959.1|6733676_6734417_+|hypothetical-protein	gnl|CDD|183518	PRK12418, PRK12418, cysteinyl-tRNA synthetase; Provisional.	3.92546e-07
CP033073.1|AYN42495.1|6729985_6731206_-|4-hydroxybenzoate-3-monooxygenase	gnl|CDD|236198	PRK08243, PRK08243, 4-hydroxybenzoate 3-monooxygenase; Validated.	0
CP033073.1|AYN42482.1|6712586_6716726_+|hypothetical-protein	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.19032e-34
CP033073.1|AYN42496.1|6731273_6732911_-|APC-family-permease	gnl|CDD|223605	COG0531, PotE, Amino acid transporters [Amino acid transport and metabolism].	2.90028e-50
CP033073.1|AYN42481.1|6711447_6712026_-|IS630-family-transposase	gnl|CDD|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	1.2779e-25
CP033073.1|AYN42487.1|6720924_6721938_-|hypothetical-protein	gnl|CDD|370676	pfam09770, PAT1, Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.	7.96603e-06

Protein sequences

>CP033073.1|AYN42489.1|6722941_6724957_+|hydrolase
MPSPHPPRPPFPPPPAPSGESDRALVARLTGPGDARHHAVALLLARHWRPTRDHAVICLASAGYAAQLVATAAFHQVLGRMAGGVLGGALRPQLLVAVRDTVRSWAADEAARIALPELRKPTGGRGLRATNPETPESRQLAARAFQALPGASQCLLWHTEVEAEPINIPAGLLGIDPATAIAALEQAREQFRAACVRAHRELAPSSECRLHNRLLDVTIRRGGTLPPDVRRHLTACDHCRYAAEQLGHFDGGLHLLLAETVLGWGARRYLDSRPGRAAPGEWPPPPAARPAPPVTGGRHRTGPENHRRTAVAVGVGLTSLALLATVLAARSWSDDNGVPASGATWGAPGGDAARPGGTGTRSAAPPSTASAASAGESAEIAQGALRGLGSRLCLDVRGNRVAAGAGVRLAPCSSAASQQWSYRDDGLLRSAAAPSLCLTADPGTRRVELAGCHAPTGEVSYDVTVRGEILLRRRKGLALTPGSGRSTTRVAVAERDGSPEQRWVLEPGTAEMPRSRSGADAEGEGASEASGVPGAPDGQGPSDGTARAGSEASSPAGAGPDSGRRGDGDAPRGEPDRGGAVAGQGTEPRIAQVHAEEGPRRGGAGRAGRTADAVLADTVLVDVVLGDVVRTPGTAAGPFAGTPTPPAGSRTTSLLTGTADAGSQAVRALVG
>CP033073.1|AYN42488.1|6722081_6722519_+|DUF4442-domain-containing-protein
MSIGEMLAATVPMARTLNLEFQETTADKAVVSLPDQGAYHNHVGGPHAGAMFTLGESASGAIVLAAFGDQLSRAVPLAVRAEIAYRKLAMGAVTATATLGRPAADVVAELDAGQRPEFPVAIEIRRADGAVTGEMTVVWTLRPNG
>CP033073.1|AYN42487.1|6720924_6721938_-|hypothetical-protein
MWPDQQPPGGAQNPQHNPYQQPGYQQPNPYQQPGYQQHPQAGPYEQQPPWGQLPAAPSPQPPQGGGRSTKLVAIVAATAVVVTAAVTGYLVLGGGSKDDEADNGKGGHSTASSPPAVPLDPPASSATDNPRTSGTEKPTVAGWKLVVNPKYGTAFDVPAGWEVERPGSFSFFEDQQKGDGSPYIGFSGSTYLKPDHCTSEKGGTKESHALVASGTKGENGAKDTAGIARGDSAAFVFGGYTDQSDAAKKYLRIGKARKYTTASGVKGSVATSYVVGVPKKDKCDTDGKATTFAFKNSKGSFVGWTLYGAKGVKDEIPDATVDKILATVRLHGDPIVE
>CP033073.1|AYN42486.1|6720039_6720885_+|spermidine-synthase-like-protein
MTDQIPVSRTTDHGTAKLMPDVDRERAWLLTVDGAPQSYVDLDDPAYLEFEYARRLGFALDAVAAEGVPLDVVHLGGGALTLPRYVAATRPGSRQDVVEADRGLLELVAEHLPLPRGSGVVTHADDARAWLEGAPDDHADVLVADVFGGSRIPAQTSTLAYARAAERVLRPGGVYLANLADAAPFGFLRAQLANLAAVFEELALIAEPAVLRGRRFGNAVVVASHRPLDIATMARRSAADAFPARVEHGASVREFIGSARPVEDAGAVPSPEPPAGAFGIG
>CP033073.1|AYN42485.1|6718467_6718695_+|hypothetical-protein
MSALREICGATWTYPSDPTVLRRQGFTETFAGVEVTCDSEPHSCNPHDVVHSAPIFVGEKLRGIKYWGPGYVPVF
>CP033073.1|AYN42484.1|6718067_6718484_+|hypothetical-protein
MTERRPYPEISSEEELDELPYLAYLEIAGHLRQIALEEDDDPVAVARQLLERAPANNRFRIVTIQRFSLRPGPPVPEPFVGPQCRAMDALESGVVRCELEAHSDGLDHAGRVLRDGRAAEVHYWRATSGAEVRHERAT
>CP033073.1|AYN42483.1|6716997_6717564_-|hypothetical-protein
MLWPKSIRSTLKTGPDREIIAAYPYRNACSTSVWARLIDGASTSITFAGYTNYFVWQEHPRLADRLAAKAASGCVVRFLVGDPDSEITRRREEIEGVPLTVSTRIRITLDALSKIEGRGVEARYSDGHIALSVFTFDDEMLVTPHLSSLLGHESPMLHLRRLGENGLYDRFASHVAALWEEGRPVSSA
>CP033073.1|AYN42482.1|6712586_6716726_+|hypothetical-protein
MKADTAGALSALRSLGGAIGAVAALPLVPIAAAGIGAIASAAVTAGAGVGALALVAIPAIKGVTSVIQAKTAAEKEAASSTDNSAAANVRAAQNALQMAGAQQALTAAHRNAAQSIAQANRQVEDAERAVAQAAQRAADQRVQSAQNVERAERSLADAKRQSTDAEEALTRARKDAADQLAALDDKLADGKLNQRDSVLRVAEAQDELNRVLADPKATDLQRERAQLAYDQALQAQKEQDKSYRQTQEEARKAKKEGVNGNEQVKKATQDVADAQRNVRDQVEALAQAHSDAAKAEVQAAQQVADAQRSLTDAVKNAATTQVTAAESIESAERGVESARLSSIDTTTTATTKADTYREALAKLTPEQRDLYDSLAGPKGLTKAFKDWSTSLQPDVLPLFTRGVNSAKNSLPAFTPLVRNSASAVKELMDRASKQLKTPFWQGFKKDIQDNAKPAIVGLGVAFGNVLKGMAGIVDAFLPHMDGISSRMQKDTERFADWGTKLKGSPAFEKFLSYAGKHGPIVAQTVSDIASAVLSIGSALSPISGPLLKVISGVAVGIASVADTLPWLIRLIYGVWVATRLWTIAVAAFNLVMAANPIVLVIVGLVALAAAVIYAYKHFGWFRDVVDATWHGIATAAEWAWRSALQPVFALIWGAIQSVGGAAVWLWRNVFAPAWTGMVTVAKYAAAIIVTLVVAPIIVAVHALGLLFGWLWTDCAEPTWNAIAGLALWLWNKALYPALSAIKGEVVGVGDAFLWLYNHAVKPSADWISDKADWLWNKALAPTFKSIRGGLSSVGGAFHGLYNDYVEPVVSDVANAGDWLYYKGLKPAFDGIKSAVGLVADAFDGARKAIKSAWDKVAGIVAKPVNFVIDFVYTHGIKAVWDKVAGFVGLDKLPKAPKLLPENPKLLEAGGTIGEGWGIARPMKTNRPTAIVGEGDPRYPEYVIPTDPKYRGRAKALHASAGTQLLESGGVIGGAWDWTKDVFSTVGDWAKTTGDLMIHPGKVWDRLIRPTMDHVKDGVGDGPMGKVITGIPKRMVGGLKDMLVNAVTNMFSGGGGVGQWVKPINVPYGTRFGVPGRMWSSGHHTGLDFPAPVGTQVHAVDGGTIVGVGTAGPYGNHLEIDHGGKLVSLYAHMSEILAGLGQVVGQGDVVGLSGATGNVTGPHLHLEARVGGRAVDPMPYLESIRTGGKVSQSIAAAKNFAKSQLHYFGWGPGEWPSLDRLWTGESGWRWNAENPSSGAFGIPQALPGSKMASAGPDWRTNPATQIQWGMGYIKNRADYGSPSAAYGRWLNRHPHWYDDGGYLPPGLSLVANGTGSPEPVFTSTQWDDIRAARGAGRPVTINVESTTVLDGQELSGMVDKRIEFYDGEVATSLNNGRIVI
>CP033073.1|AYN43957.1|6711971_6712448_-|transposase
MEAAERFRQGDENPIIAHDLRVSVRSVQRWRRAWSQDGPRALTSRGPASLPLLSDELFAVLERELAKGPVAHGWPDQTWTLSRIRTLIGRRFHKSYTWQGVAALLKRHGWSCQVPARRAIERDETAVAGWVKETWPSVEGPWRRSTPGSSSRTKPASR
>CP033073.1|AYN42481.1|6711447_6712026_-|IS630-family-transposase
MAALDAWLVFEDEAGFSMTPPTTRTWSRRGHTPVIRVRGRSRRRLSVAALACYKTGEPSRLIYRPCPDARPDGRKSFSWKDYRDLIQTAHQQLGGPIVLVWDNLNTHLTAGMRRYIADRDWLTVFQLPPYSPDLNPVEGIWSVLRRTTTANRAFADPDDLITAVRRGLRQLQYRPDVLDGCLTGTGLRRQPP
>CP033073.1|AYN43958.1|6725252_6726302_-|UPF0104-family-protein
MRKDDVPVSSPAPPTPLSAARPPRAQPPCPAATARPASRTPPRPLRLALSLAPLLLAAGWATAHRSVLYEGARRLVAADPRWLLAGAGLTCLSWVAASCVRQGALPERLPPGPLLASQFAAGAANHALPCGLGAHAVTLRFLRGRGVPLERATASIGLYSLVRSTAKTLVLLVFLAVSPAWRRLGALAPPGRVLVPLALAAGGAVALAGVLVTVVRPVRRPVALLLRSALTDVRVVHARPSRVLALWGGAVAMPLVQAGTLACVGASLGLGLPWEQVVLACLAAGTAVGAVPAPGGLAVDAAQVWTLVAFGAPPAPATATVVGYRLLTDWLPLLPGALTLSALIRAGVL
>CP033073.1|AYN42490.1|6726533_6727178_+|DedA-family-protein
MHVQEWLDSVPAAAVYAVVALVIGLESLGIPLPGEIILVSAALMSSQHSGVNPVVLGVCATAGAVIGDSIGYAIGRRGGRPLLAWLGARFPRHFGAGHVATAERSFQKWGMWAVFFGRFVALLRIFAGPLAGVLHMPYWKFLIANVLGGICWAGGTTAVIYYVGLVAEDWLKRFSYLGLVVALLIGLVSVLVLKRKAKKAQHAEPEPEPVTAGE
>CP033073.1|AYN42491.1|6727234_6727762_-|gamma-carbonic-anhydrase-family-protein
MTHKALIVGIGGKEPRVDPGAFVAPTASVIGDVTLHAGASVWYGAVLRGDVESISVGARANVQDNVTLHADPGFPVTVGERVSIGHNAVVHGATVEDDCLIGMGATVLNGAVIGAGSLVAAQALVPQGMVVPAGSLVAGVPAKVKRELTAEEREGVTLNGTLYAELGKAHQDVHR
>CP033073.1|AYN42492.1|6727871_6728636_+|acyltransferase
MSKRKNTFSSWRRRLAQRAVHAGWSWVRSAGSVTAEHPGGYRFGSIGEATRLAFPLGTVFGEPWIRLGSHCIIAEQVTLTAGLMPDLDLGPDPILRIGDGVVLGRGSHVIADTTVSIGSDCYFGPYVYVTSTNHSYDDPHQPIGRQWPRMEPVEIGPGCWIGTGAVILPGARIGRNVVVAAGAVVRGTVPDHAVVAGAPARVVRRWTPGDGWQPPLRTPAPVPIPDGTTPEQLRALGELDEDVVARLAALEPEA
>CP033073.1|AYN42493.1|6728767_6729340_+|XRE-family-transcriptional-regulator
MSDLELLTQSLARNVRHWRAVRGFTLDVLAARAGVSRGMLIQIEQARTNPSIGTVVKIGDALGVSVTTLLDYEQGPTVRIVPAERAVRLWHTEAGSYNRLLAGTEAPGPLEMWDWRLMPGESSPSEPHPGGTVELVHVIAGELTLVVDGTEYRVPAGASASFEAAVPHRYANRGDLPMEMVMAVSVPPVP
>CP033073.1|AYN42494.1|6729402_6729960_+|hypothetical-protein
MRPPIGDFDTATPARDCLDELTAPVADAVRDWQGAVPADRILYVDTDPRWADTAVFVEHYGRDLLECSANCVVVAGKRAGMTTLAACVVLSTTRVDVNGAVRRQLGARKASFAPMETATGETGMEYGGITPVGLPTGWPVLVDAAVVDLPYVLLGSGRRRGKLLVPGKALAELPGAVVREGLGVA
>CP033073.1|AYN42495.1|6729985_6731206_-|4-hydroxybenzoate-3-monooxygenase
MTSPSPHSDSPAVSRRPVVIVGAGPAGLTVGNILRAAGVDCLVLEAGTRAFIEQRPRAGVIEEWAVRGLEQRGLGGNLTARAQRHTECEFRFDGRGHRFDYGGLTGRHHWVYPQPWLVTDLVHEYADVRGGAIRFGVRDVRLHDLDSDRPSVSYTDPDSGERQLVRCDFVAGCDGARGASRAALPERARISRHDYGIGWLALLAEAPPSSDCVLFGMHPDGFAGHMARGPGLTRYYLQCPPGDDPDDWPDERVWDELQRRLHAADRPPLTRGPLLEKRVLDMHNYVVEPMVYGRLLLAGDAAHLVAPIAAKGMNLALNDAFLLGDGLVAHLTEGDDTGLDGYAEACLRRVWDYQEFSQWLSEIYHGLSHGDPFRAGTARARLRRLFTSPAAAAAFAEQYLGTAGAY
>CP033073.1|AYN42496.1|6731273_6732911_-|APC-family-permease
MVKVDHAVPQATTESGGLRRDVGLIGLMWASVGSIIGSGWLYGAEKAVVVAGPAAIISWVIGAVAIVLLALVHAELGGMFPVAGGTARYPHYAFGGLAGMSFGWFSWLQAATVAPIEVEAMIGYAGHWEWAQGLQHADGTLTPVGLLTAVLLMAVFVGVNFFGVRALAHTNSAATWWKIAVPLGAIFIIAAGNFHASNFTSEGFAPFGAKGMLGAISSSGIIFALLGFEQAIQLAGESRNPKRDLPRATLGSVAIGAVIYILLQVVFIAALPHASFAHGWAKLDFPGISGPWAGLATVVGLGWLGWVLYIDAIISPGGTGLIYTTATSRVSYGLAKNGYAPKAFARTDKRGVPWFGLLMSFVTGVICFLPFPSWQELVGFITSASVLMYAGAPLAYGVFADRLPHHERPYRLPGGKIISPLSFAVANLIIYWAGWDTLWRLGFAILLGYVLLGSYAWYATSKRLPDAPRLDFRAAQWLPGYLLGLGLISWLGGFGGRGVIPLWWDILVVAAFSLGVYHWARATASSPEAIERSIEEVVVTDAPAH
>CP033073.1|AYN42497.1|6733126_6733534_-|CoA-binding-protein
MYGDDATIRRILTELGDTWAVVGLSANRNRAAYGVARVLQRFGKRIVPVHPKAETVHGERGYASLADIPFDVDVVDVFVNSALAGAVADEAVARGAKAVWFQLGVVDADAYERTGAAGVEMVMDRCPAIEIPRLN
>CP033073.1|AYN43959.1|6733676_6734417_+|hypothetical-protein
MLRILDVRTGEPVAAAPARRGLTRVEAHASGLDPTALRVLLTADLLVRALELGGTPVWTILTAPREQPELRTAATHLAIRPFEDDRDLASGLGEAQVIHVTGPHAATVRAEGPVAAVAPVAWTGPEPPLPVLLADPAALRLALLSVPRRETARLDATALDRAAGQLAHWRRAVAGWARRPSRPVPEEIRTRLRAAWDDDLDLPGSLAVLRDVEHAPDLPDGARFETYAHADRLLALDLLRDLGNPA

Crispr_ID: CP033073_16

• CRISPR_ID: CP033073_16
• CRISPR_location: 6968266-6968352
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of CP033073_16

Consensus_repeat	Method
CCTACCCGGGCCGGTCCGCCCGCACC	CRISPRCasFinder

spacers of CP033073_16

>16.1|6968292|35|CP033073|CRISPRCasFinder
GGGCGCCAGGAATCTTCGTCCGGACGCGCCGGAGT

CRISPR arrays and Neighbor proteins around CP033073_16

CRISPR arrays

The CRISPR arrays of CP033073_16

>merge|CP033073|16|6968266-6968352|CRISPRCasFinder
CCTACCCGGGCCGGTCCGCCCGCACCGGGCGCCAGGAATCTTCGTCCGGACGCGCCGGAGTCCTACCCGCGCCGGTCCGCCCGCACC

>CP033073|16|16|6968266-6968352|CRISPRCasFinder
CCTACCCGGGCCGGTCCGCCCGCACC	GGGCGCCAGGAATCTTCGTCCGGACGCGCCGGAGT
CCTACCCGCGCCGGTCCGCCCGCACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN42654.1|6967244_6967913_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
CP033073.1|AYN42651.1|6959410_6959659_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42650.1|6958989_6959412_-|hypothetical-protein	unknown	unknown	gnl|CDD|237030
CP033073.1|AYN42653.1|6965259_6965616_+|transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|197713
CP033073.1|AYN42649.1|6951250_6953404_-|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|224331
CP033073.1|AYN42660.1|6973310_6973994_-|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl|CDD|176506
CP033073.1|AYN42656.1|6970007_6971678_+|FUSC-family-protein	unknown	unknown	gnl|CDD|379231
CP033073.1|AYN42658.1|6972279_6972672_-|VOC-family-protein	unknown	unknown	gnl|CDD|319925
CP033073.1|AYN42657.1|6971674_6972283_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
CP033073.1|AYN42662.1|6975844_6976600_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|212491
CP033073.1|AYN43977.1|6956304_6957093_-|pectate-lyase	unknown	unknown	gnl|CDD|367395
CP033073.1|AYN42648.1|6950488_6951076_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42661.1|6974408_6975806_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42652.1|6959667_6963960_+|cation-translocating-P-type-ATPase	unknown	unknown	gnl|CDD|319840
CP033073.1|AYN43979.1|6964050_6965130_-|NADH:flavin-oxidoreductase/NADH-oxidase	unknown	unknown	gnl|CDD|239242
CP033073.1|AYN43980.1|6969271_6969820_-|DUF5134-domain-containing-protein	unknown	unknown	gnl|CDD|375044
CP033073.1|AYN43978.1|6957550_6958909_+|SGNH/GDSL-hydrolase-family-protein	unknown	unknown	gnl|CDD|238868
CP033073.1|AYN42663.1|6976596_6977667_+|low-specificity-L-threonine-aldolase	unknown	unknown	gnl|CDD|99748
CP033073.1|AYN42659.1|6972743_6973283_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
CP033073.1|AYN42664.1|6978370_6979096_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|153251

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP033073.1|AYN42653.1|6965259_6965616_+|transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	3e-11	38.5	0.1

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN42657.1|6971674_6972283_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.24609e-17
CP033073.1|AYN42650.1|6958989_6959412_-|hypothetical-protein	gnl|CDD|237030	PRK12270, kgd, multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit.	0.00040567
CP033073.1|AYN42653.1|6965259_6965616_+|transcriptional-regulator	gnl|CDD|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	5.07922e-09
CP033073.1|AYN42649.1|6951250_6953404_-|HEAT-repeat-domain-containing-protein	gnl|CDD|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	0.00123635
CP033073.1|AYN42664.1|6978370_6979096_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase	gnl|CDD|153251	cd07989, LPLAT_AGPAT-like, Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like. Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.	7.5806e-57
CP033073.1|AYN42656.1|6970007_6971678_+|FUSC-family-protein	gnl|CDD|379231	pfam13515, FUSC_2, Fusaric acid resistance protein-like.	1.96688e-22
CP033073.1|AYN42658.1|6972279_6972672_-|VOC-family-protein	gnl|CDD|319925	cd07264, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	3.67135e-19
CP033073.1|AYN42662.1|6975844_6976600_+|SDR-family-oxidoreductase	gnl|CDD|212491	cd05233, SDR_c, classical (c) SDRs. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human prostaglandin dehydrogenase (PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, PGDH numbering) and/or an Asn (Asn-107, PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.85175e-23
CP033073.1|AYN42654.1|6967244_6967913_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	2.30961e-12
CP033073.1|AYN42660.1|6973310_6973994_-|glycerophosphodiester-phosphodiesterase	gnl|CDD|176506	cd08563, GDPD_TtGDE_like, Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in Thermoanaerobacter tengcongensis glycerophosphodiester phosphodiesterase (TtGDE, EC 3.1.4.46) and its uncharacterized homologs. Members in this family show high sequence similarity to Escherichia coli GP-GDE, which catalyzes the degradation of glycerophosphodiesters to produce sn-glycerol-3-phosphate (G3P) and the corresponding alcohols. Despite the fact that most of GDPD family members exist as the monomer, TtGDE can function as a dimeric unit. Its catalytic mechanism is based on the general base-acid catalysis, which is similar to that of phosphoinositide-specific phospholipases C (PI-PLCs, EC 3.1.4.11). A divalent metal cation is required for the enzyme activity of TtGDE.	1.03422e-53
CP033073.1|AYN42652.1|6959667_6963960_+|cation-translocating-P-type-ATPase	gnl|CDD|319840	cd07539, P-type_ATPase, uncharacterized subfamily of P-type ATPase transporters. This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.	0
CP033073.1|AYN43979.1|6964050_6965130_-|NADH:flavin-oxidoreductase/NADH-oxidase	gnl|CDD|239242	cd02932, OYE_YqiM_FMN, Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing agent. The YqjM enzyme exists as a homotetramer that is assembled as a dimer of catalytically dependent dimers, while other OYE members exist only as monomers or dimers. Moreover, the protein displays a shared active site architecture where an arginine finger at the COOH terminus of one monomer extends into the active site of the adjacent monomer and is directly involved in substrate recognition. Another remarkable difference in the binding of the ligand in YqjM is represented by the contribution of the NH2-terminal tyrosine instead of a COOH-terminal tyrosine in OYE and its homologs.	0
CP033073.1|AYN43980.1|6969271_6969820_-|DUF5134-domain-containing-protein	gnl|CDD|375044	pfam17197, DUF5134, Domain of unknown function (DUF5134). Proteins in this family are uncharacterized, but have been identified as members of a gene cluster for the synthesis of the tetramic-acid antibiotic streptolydigin, which inhibits bacterial RNA polymerase (RNAP).	1.6846e-13
CP033073.1|AYN43978.1|6957550_6958909_+|SGNH/GDSL-hydrolase-family-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	2.19844e-92
CP033073.1|AYN42663.1|6976596_6977667_+|low-specificity-L-threonine-aldolase	gnl|CDD|99748	cd06502, TA_like, Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.	1.50094e-139
CP033073.1|AYN42659.1|6972743_6973283_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.07566e-09
CP033073.1|AYN43977.1|6956304_6957093_-|pectate-lyase	gnl|CDD|367395	pfam03211, Pectate_lyase, Pectate lyase.	1.8897e-92

Protein sequences

>CP033073.1|AYN42654.1|6967244_6967913_-|TetR/AcrR-family-transcriptional-regulator
MSPRSASVNEELRRRSRERLLQAAVELVGEHGFEATTLGDIADRAGSARGLVSYYFPGKRQLVQSAVHRLMHRSLEEALEREPRTEDGRERLARAIDVILGLARDRPVLMRQHMAGLLQAEGFVQCPEQRRLSELLSDTVARYGSQDVAAGYPVLRALLMGAVYAALVPGVPMPVPLLRGELFRRYGLDWELGVPPERDPGTAAQQRDLSRFFATEERPSSP
>CP033073.1|AYN42653.1|6965259_6965616_+|transcriptional-regulator
MTDTAATGRDLPHPERENIRLEPVLHALSDPMRLRIVRELAGRGAELTCSQFDLPVTKSTTTHHFRVLRESGVVRQVYRGTAKMNALRRDDLDGLFPGLLDSLLSAADRQSRRLGDAA
>CP033073.1|AYN43979.1|6964050_6965130_-|NADH:flavin-oxidoreductase/NADH-oxidase
MSTLFQPLTLREVTIPNRVWMASMCQYSAESEGPLTGAPHDWHFAHYAARATGGTGLIVTEATAVSPEGRISPYDLGLWNDTQVEAFRRITRFLVAQGTVPAVQLAHGGRKSSTERTWKGGAPIGPEAHGWQPLGPSAVPFDEHHPVPTELTTDQISEIVGQFAAAARRAHAAGFEIVEVHGAHGYLINEFLSPHSNHRTDAYGGSYENRTRFAREVVDAVREVWPEDKPVFFRISATDWLQEGGWTVEDTVRFARDLHAHGIDLLDVSTGGNASGVTIPTGPGYQVPFAARVKAETPLPVAAVGLITEAEQAQKILANGEADAVLLGRELLRNPYWARQAARELGGEIRVPDPYHRSV
>CP033073.1|AYN42652.1|6959667_6963960_+|cation-translocating-P-type-ATPase
MVLGLLTEPSAAARLLPAAPRLLARAAAPAAGMAAGAAAGTARAGVRGADAAARVVRVARNALPGAGDHWRSGARAHLALRPVDQEEARRAGGTGHRARRLAEALAEHPDVLVAYWDQGLARLVVTATEEEATDRVVEHAAELAGQHGLVLAGGDVEETTHPADPAGVRAAAATLAADGAGIGVALAAYALRLPPSPRMVTAVVTLLRENPRFRAWLRARLGDSRMDLVLACANAAVHGVGQTPTSLVLDGVLRACQVAETVSRSAAFDAVHDELCAPERISLAPEGLPRPPLRESPALEYASHASAGSLLGAAATLLVKHDGAEAAEAVLAGSPKAARYGPAAFHAVLSAALARTGVLVRDPARLRQLEMAGAIVLHAGALRTDEGEADPWTEPVLDAARRAGLRVVVVDDPALEDFTGLADQVVDARRPLDDVVCEARGDGGAVLVVARVREAGRHDVLAALRAADIAVALTDRDGAVVWGADILALHGLPDVWRVLTAIPAARSVGRRAQTLARSGAALSGLLVAVGETGGGRGRRSLLPGLRHAPVDAGAAAALISGARAALSVAAAGAPHPRPRVHWHELDTDQARERLAHEPEAAPGPFDELTTRVRRATRRVTRHPAVAPARWSYQLGRAVRGELQDPLTPVLAVGSAASAILGSVADALLVVGALDLNALVGGIQRLRAERALSGLVADQKRKARLVPPESEAPAGGTRTVEAGGLRPGDVIQLKGDDVVPADARLLWQDGLEVDESALTGESLPVEKQTDPTPHAPVADRSCMVFEGTTVVAGQARAVVVDIGDRTEAARAVHLASRTPPSAGVQARLQELTRKALPLTLAGGATVTGLALLRGTPIHEAVSGGVAVAVAAVPEGLPLVATVAQLAAARRLSRGGVLVRTPRTLEALGRMDTICFDKTGTLTENRLRLVRTCDADGTVHGVDDPGSAGTVRAAARACPRLNGGSDRPVHATDEAVLAAAGPDPDWTQLADLSFEAARGYAAAVGRGGDGPPVLVVKGAPETVLPACAGLPEHAADSAHALAGSGLRVLAVAERRLGADERESDALERELEGLEFTGLLALSDVPRETSTALVNGLDGAGVRPVMLTGDHPQTARSIAADLGWPEDTVVVTGDELAAADRAARARMLRDAGVVARVAPEQKLQVVEALRDAGRVVGMVGDGANDAAAIRAADIGVGINARGSAAARNAADIVLTADDLTVLIDAVGEGRALWHSVADAIAILIGGNAGEVGFGIIGTLLSGRAPLSTRQMLMVNLFTDLFPSMAVAVTEKEGEADLGHVEEAAGVLGEPLLRQIRHRALTTCLGAVTAWLIGRFTPGTARRSSTMALCGVVGTQLVQTLLDRRDSRLVQVTSLGSALALVAVVQTPGVSRLVGCTPLGPVAWAGVVAAIALALAGQRTLPRLEQTVGRLLPT
>CP033073.1|AYN42651.1|6959410_6959659_+|hypothetical-protein
MPTAEPAHDLGTAALRSGGEGQGPASAEEKASERRGTSAGADDAGDSGAPAQPEAALGDAVPTPTTSPGPLGPTARPDRTTL
>CP033073.1|AYN42650.1|6958989_6959412_-|hypothetical-protein
MSTFPAPGPPSVRGAGRGWVNQATAAPVRATGHSTTPAAPSSPAPAYTAIRRPRGETAPTLSRVSSAALPTVPAPGTLRSTEAAPCRGAVRTDDDFCSAMTLLGLIRPVCPTECPRLHRSSPLHPGNVTDPARATVPASR
>CP033073.1|AYN43978.1|6957550_6958909_+|SGNH/GDSL-hydrolase-family-protein
MKPPTRASLAPLLGTCVLVLALVVTASALTALVTGTLPTTGTAPTTGTAPAAAARPGRHWVNTWTGMPQPTEPANLPPAPYTGARSVLVDTTLRQTVRVTIGGPRIRLRFSNAYGDTPLPLTAVTVALPRDGRAGVSAVVPGSVRRVTFAGRDSATVPVGAELVSDPLDFALSAGTELTVTAYTAPGQASLALTSHPGSRTTSYLVHGDRTCDEDLPGATGVDHWYLLSDVEVLAPGRAGAVAVVGDSLTDGRGSTTNGNDRWPDQVFDRLRTRPDTSGVAVLNQAAGGNRVLADGLGPNVLARLDRDVLSRSGVAWLILFEGVNDIGTAEATSEAQRAVTADLVAGYRQIVVRAHAQGIRVYGATLTPFGGNTLYDDPAREREASRERVNAWIRTPGHFDAVIDFDRAVRDPAAPDRLLPALHAGDWLHLNPQGYRVLAAAVPEGLFRPTR
>CP033073.1|AYN43977.1|6956304_6957093_-|pectate-lyase
MTSHTSPHALLGGLAALGLTFGMIMTSGAPAGAATWPSANGSQAVSSTISVSGTKDYGMKRLYGSGDLGSDSQDEDQGPILELAPGAVVKNVIIGAPAADGIHCLGSCTLQNVWWEDVGEDAATFLGSSSSNVYTVTGGGAKEASDKVFQFNGAGTLNVSGFAVKNFGTFARSCGNCKTQYKRTINLSGIEATYKGNKLVGINTNYGDSATLKNITIVGDTSKKITPCQKYIGNNTGKEPTTNGSGPDGTYCKYSSSDITYK
>CP033073.1|AYN42649.1|6951250_6953404_-|HEAT-repeat-domain-containing-protein
MFTGIDEVDWATLRHAHGSAEDMPGWLRALASTDAAERAAALDRMYGAVHHQGRVYDSTLACVPFLFALAARADVPDRGCIVELLVSIGGLGGSHGTGGVSGVDGAGGLSGTEGVEGGVRSVGGGEIGVSGAGGSHGIGDIDGESPADEGPDRRAREAVRAGAASFARLAADPDPAVRRTAAGAVVRFLDEPLRVLELLRQRLHDERDDCVLLALTEALGLFAHRYPAHADTAMAHLADHSGPSSSPALRLAALGQLALHAPGRLPVGLVPTVVRLLRERSARRVLAREHRGPDTLVGRIRRLRPSDEEGAVLLRTLHGALGDRVMARLALLAGQLTSPDPVDRCNAVWMSAGLFRGWRGDHGGVVRLLGTQLGTEEDRLRDAAVSVLAELFALAVPAADDLHALVATRPDLWTHRWERCPPTLGGPLKALTRAGDPRAVPALAQLLAGPAAPVGLGFEIAHLGRAAAPLAPALRHRLGRVPLASPTAARLAAPLLTAVRATGDTDAVPELLRLLSDPPGGPEARDAVVGQVIGTLAALGAAEQARPLLGRLLDTRHAAVAAGALWSADGDVSAVLPVLVRELTQADPVARHHAVRALGSMGPAARAALPALRRLARSGPARERVPAACALWHITAEPGPVRPVFRAAWAEDPRTRVPVARCLTTMGSAAAPLRDLVTSELDAPRRHMATGDGAYGSQDIPADEELIRLCREVLASL
>CP033073.1|AYN42648.1|6950488_6951076_+|hypothetical-protein
MKAFRGPKVWLWRWRRNPLKRRADVLEAWVVLGTLLLTVLAGVPAGLAAARSVEHGLARQRATWHPAVARVAARVPGPSRPSGSHASAGERIWAEVRWTAADGSAHTGQVRVEPDIRAGTPVTVWTDPRGHLVSRPTTASEAAFRATLIGLLVGVSTAAVPLAGGLAARARLERRRLDAWDTEWARLGPQWGRTV
>CP033073.1|AYN43980.1|6969271_6969820_-|DUF5134-domain-containing-protein
MHGPVSAAWLLVALCGATGAYCLLRLRSGVEEQRRAAGGEALMGFGMAVMAVPAAVFTPPRWAWPVYTAVFGAAALRALWTARGVPRHLHHLVGSAAMVYMAVAMAGAPPAAHHAHGGGVPLVTGALLLYFTGYVLLAGARLVPATGTADAADPARWGDRPELARACRLSMGIGMVTMLLTM
>CP033073.1|AYN42656.1|6970007_6971678_+|FUSC-family-protein
MSSATPHRLPLAGVLRLGRPSDIWFKPALSVAVAVAPPNLILLALGRLDLAMYTMAGSLCALYGHNRPYAARARLLAWVVLGMVGGLAVALLAAAFTQHAVVLVAVGAVLAAVQKAACDATRVGPPGNVVLTFISSASLFAPQTPGQLPGHLGLALAAGAWAWLVGMAPGLVRPHGPERRATAQAMRAAAAYADTRGTGDGHAGARAAGAAAIHAAWQSLLATGARPDRTRRALEQLLVRAEVALAAPADTDPAPLRAWARDLRGTGRVPRVAAPREHADELLGVAVEQAAPRPSLRNRLAPLAPLAARTATGCALAGYASLALGVGRPYWALVTAASLYQANVTLTWSRGVQRVVGNLVGVLVFAALVPLAHLHPAALVLCALVLNCAAEALIGRNYWLGTVCVTPMALLVTEFAHVQDSTELITERVADTLVGAAAGFVAAVVVTNRRAGDRLELALTTAERARENAARLLAEAQPAPHALEAARRGLAAALVDLRATADAAAGEWWQRALPEDRVVLTEQSGHRTLAATVRRQGLVPRHRDRDPGRTTEDIRP
>CP033073.1|AYN42657.1|6971674_6972283_+|MarR-family-transcriptional-regulator
MTATNGAATPASDATGAGTGPGPVRNDTVAAVVRQWQAVHPELDTGPMEVIGRINRCAALLQQAEDAPLRRAGLSRAEFDLLGALRRTGHELTPGELARETFSSGAAVTKRLKRLTERALVERRGDTRDRRVAHVRLTDAGRDLVDGILPEQLAYETAVLSVLDPEGQDGLAGLLAELLSRLEGRMNALASPPPPPSRAAAR
>CP033073.1|AYN42658.1|6972279_6972672_-|VOC-family-protein
MVHVLSSRTLLRPTDPERSRGFYGGQLGLSVYREFGTGPERGTVYFLGGGFLELSGRSEAPPSPAVRLWLQVSDVTAACEELRARGVEIVRPPVREPWGLIEMWINDPDGTRIVLVETPADHPLRYRPEV
>CP033073.1|AYN42659.1|6972743_6973283_+|GNAT-family-N-acetyltransferase
MDTPATALTFRDAVDADVDALVALIQAAYRGEGGQAGWTTEADILEGRRTDPEGVLAVLKAPLSRLLTVEQDGRVVACCQLEHRGDHAYFGMFAVNPAQQGSGLGGAVMAEAERLARETWDVTEMRMTVISVRNDLIAWYERRGYRRTGQTEPFPYGDERHGIPQRDDLEFEVLVKPLV
>CP033073.1|AYN42660.1|6973310_6973994_-|glycerophosphodiester-phosphodiesterase
MNFLTIGHRGVMGVEPENTLRSFVAAQQAGLDLIELDLHLSKDGALVVMHDADVDRTTDGSGPIAEKTLPELRALDAGRGERVPVFEEVLEAVHSPLQAEIKNVAAARALAEVMRARDLTARVEVSSFHDEAVAEMSRLVPGVRTALIASRYGPDVVDRAVAVGAATVCLNIRRLTLETVEHARASGLRIIGWVVNSQPQLRLVRALELDGATTDYPDIKRTGRFTA
>CP033073.1|AYN42661.1|6974408_6975806_+|hypothetical-protein
MTEILVQAGAEEQIPSLIRVVEHPAWPVLKNAVEQIRPWQSTDGSIDFGAEGAPRRDDAVAAVERVVGAVEQLSPLLPHDAAYHGALVQDLRRWVEGGFEVPDFLDSLLAFNPAANRADGLQHLVVFPMYTQNGNPDRNLEAVVLRMVWPEWLAELERTRYDNPLFCGITFEDFTSGYDTNSAVLFPETIAVRQAPERFSWGGIFCDREAARFRRVTDAAVDVLGLDLPEDIAAMVHDQKRCEEAFVLWDMVHDRTHSHGDLPFDPFMIKQRQPFWMYGLEELRCDLTAFKEAVKLQADGVPQARDVQYAVLFDRMFRFPVTGDRVRNYDGLGGQLLFAYLHKHDVVRWTDNRLSIDWERAPQVTNQLCAEIEKLYKDGIDRPKLVHWFAGYELVATYLAPHPGSRWAKGPDALDLTQPPRRLVDDVLPDEFPLSMFYEALSKKLKNVIASTRGITADGAERLAA
>CP033073.1|AYN42662.1|6975844_6976600_+|SDR-family-oxidoreductase
MGNGANGALSGAVIAVAGAGGPAGRAALLRLAEAGATVIGADNDPERLSEAVDAARYAAGGATVTGDTVDLLDLQSTRDWAAHIEKDFGRVDGLVHLVGGWRGSETFTKTSLDDWDFLEMLLIRTVQHTSLAFHEALQRSDRGRYVLISAAGASKPTAGNAAYSAAKAAAEAWTLAMGDYFRKAGGTEGPTSAATILVVKALVHDAMRAERPNAKFAGFTDVKDLAEAVEGVWSKSAAEVNGNRLWLTEKP
>CP033073.1|AYN42663.1|6976596_6977667_+|low-specificity-L-threonine-aldolase
MNPPRTDARRHHDPEVRGFASDNYAGAHPEVMAALALANHGHQVAYGEDDYTQNLQRIIRSHFGATAEAFPVFNGTGANVVALQAVTDRWGAVICAESAHIHVDEGGAPERMGGLKLLTVPTPDGKLTPELIDRQAWGWEDEHRAMPQVVAITQSTELGTLYTPDEIRAICEHAHAHGMKVHLDGSRIANAAASLDVPMRTFTNAVGVDILSLGGTKNGALFGEAVVVLNQDAVRQMKHLRKMSMQLASKMRFVSVQLEALLAKDLWLRNARHANGMAQRLAEGVRAVHGVEILHPVQANGVFARLPNDVSERLQKRFRFYFWDEAAGVVRWMCSFDTTEDDVDMFVAALKEEMAR
>CP033073.1|AYN42664.1|6978370_6979096_-|1-acyl-sn-glycerol-3-phosphate-acyltransferase
MAELVYRPVIGLAKTLFKAWDLKIDCKGSENIPPSGGAVLVSNHISYLDFIFNGLAALPQKRLVRFMAKESVFRHKVSGPLMRGMKHIPVDRRQGEAAYAHALDSLRSGEVIGVFPEATISESFTLKSFKSGAARLAQEAGVPLVPMAVWGTQRLWTKGHPRNFGRSHTPVTMRVGEPVEAPRDQYAGAITRRLRERVQELLEAAQRAYPARSGAEESWWLPAHLGGSAPTAEQLRAAEAH

Crispr_ID: CP033073_17

• CRISPR_ID: CP033073_17
• CRISPR_location: 7214107-7214197
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP033073_17

Consensus_repeat	Method
CACCCCGTCCCAGGCCGAGGGCGAG	CRISPRCasFinder

spacers of CP033073_17

>17.1|7214132|41|CP033073|CRISPRCasFinder
CGGGAGGAGGACGACCTCGACACGGAGCAGCCGCCGCGCAC

CRISPR arrays and Neighbor proteins around CP033073_17

CRISPR arrays

The CRISPR arrays of CP033073_17

>merge|CP033073|17|7214107-7214197|CRISPRCasFinder
CACCCCGTCCCAGGCCGAGGGCGAGCGGGAGGAGGACGACCTCGACACGGAGCAGCCGCCGCGCACCACCCCGTCCCAGGCCGAGGGGGAG

>CP033073|17|17|7214107-7214197|CRISPRCasFinder
CACCCCGTCCCAGGCCGAGGGCGAG	CGGGAGGAGGACGACCTCGACACGGAGCAGCCGCCGCGCAC
CACCCCGTCCCAGGCCGAGGGGGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN42814.1|7216893_7217925_-|LacI-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224525
CP033073.1|AYN42806.1|7210065_7210764_+|DUF4232-domain-containing-protein	unknown	unknown	gnl|CDD|379419
CP033073.1|AYN42813.1|7216311_7216662_-|glyoxalase	unknown	unknown	gnl|CDD|319911
CP033073.1|AYN42812.1|7215827_7216238_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
CP033073.1|AYN42803.1|7207126_7207906_+|thioesterase	unknown	unknown	gnl|CDD|225749
CP033073.1|AYN42809.1|7214240_7214558_+|DUF2795-domain-containing-protein	unknown	unknown	gnl|CDD|378655
CP033073.1|AYN42805.1|7208690_7209764_-|NAD(+)/NADH-kinase	unknown	unknown	gnl|CDD|223139
CP033073.1|AYN42815.1|7217921_7218827_-|carbohydrate-ABC-transporter-permease	unknown	unknown	gnl|CDD|223472
CP033073.1|AYN42799.1|7203791_7204052_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl|CDD|225170
CP033073.1|AYN42808.1|7212813_7213629_-|CAP-domain-containing-protein	unknown	unknown	gnl|CDD|349398
CP033073.1|AYN42802.1|7206298_7206946_-|transcriptional-regulator	unknown	unknown	gnl|CDD|225512
CP033073.1|AYN42810.1|7214775_7214985_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42807.1|7210992_7212756_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|349398
CP033073.1|AYN42817.1|7219806_7221123_-|extracellular-solute-binding-protein	unknown	unknown	gnl|CDD|270451
CP033073.1|AYN42804.1|7207972_7208473_-|peptidyl-prolyl-cis-trans-isomerase	unknown	unknown	gnl|CDD|238901
CP033073.1|AYN42801.1|7205265_7206288_-|DSD1-family-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|143487
CP033073.1|AYN42816.1|7218823_7219810_-|sugar-ABC-transporter-permease	unknown	unknown	gnl|CDD|224096
CP033073.1|AYN42818.1|7221358_7223380_+|beta-galactosidase	unknown	unknown	gnl|CDD|367090
CP033073.1|AYN42800.1|7204241_7205210_-|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|235918
CP033073.1|AYN42811.1|7215302_7215707_+|SseB-family-protein	unknown	unknown	gnl|CDD|377787

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN42814.1|7216893_7217925_-|LacI-family-transcriptional-regulator	gnl|CDD|224525	COG1609, PurR, Transcriptional regulators [Transcription].	6.80007e-106
CP033073.1|AYN42806.1|7210065_7210764_+|DUF4232-domain-containing-protein	gnl|CDD|379419	pfam14016, DUF4232, Protein of unknown function (DUF4232). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	2.26979e-10
CP033073.1|AYN42813.1|7216311_7216662_-|glyoxalase	gnl|CDD|319911	cd07247, SgaA_N_like, N-terminal domain of Streptomyces griseus SgaA and similar domains. SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.	9.25602e-15
CP033073.1|AYN42812.1|7215827_7216238_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.96407e-18
CP033073.1|AYN42803.1|7207126_7207906_+|thioesterase	gnl|CDD|225749	COG3208, GrsT, Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism].	2.29526e-81
CP033073.1|AYN42809.1|7214240_7214558_+|DUF2795-domain-containing-protein	gnl|CDD|378655	pfam11387, DUF2795, Protein of unknown function (DUF2795). This family of proteins has no known function.	5.38212e-12
CP033073.1|AYN42805.1|7208690_7209764_-|NAD(+)/NADH-kinase	gnl|CDD|223139	COG0061, nadF, NAD kinase [Coenzyme metabolism].	8.27185e-57
CP033073.1|AYN42815.1|7217921_7218827_-|carbohydrate-ABC-transporter-permease	gnl|CDD|223472	COG0395, UgpE, ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism].	3.93918e-64
CP033073.1|AYN42799.1|7203791_7204052_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl|CDD|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	2.37049e-06
CP033073.1|AYN42808.1|7212813_7213629_-|CAP-domain-containing-protein	gnl|CDD|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	1.09567e-45
CP033073.1|AYN42802.1|7206298_7206946_-|transcriptional-regulator	gnl|CDD|225512	COG2964, COG2964, Uncharacterized protein conserved in bacteria [Function unknown].	1.32001e-52
CP033073.1|AYN42807.1|7210992_7212756_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|349398	cd05379, CAP_bacterial, Bacterial CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain proteins. Little is known about bacterial and archaeal members of the CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family. The wider family of CAP domain containing proteins includes plant pathogenesis-related protein 1 (PR-1), cysteine-rich secretory proteins (CRISPs), and allergen 5 from vespid venom, among others. Studies of eukaryotic proteins show that CAP domains have several functions, including the binding of cholesterol, lipids and heparan sulfate. This group includes Borrelia burgdorferi outer surface protein BB0689, which does not bind to cholesterol, lipids, or heparan sulfate, and whose function is unknown.	3.62232e-45
CP033073.1|AYN42817.1|7219806_7221123_-|extracellular-solute-binding-protein	gnl|CDD|270451	cd14748, PBP2_UgpB, The periplasmic-binding component of ABC transport system specific for sn-glycerol-3-phosphate; possesses type 2 periplasmic binding fold. This group includes the periplasmic component of an ABC transport system specific for sn-glycerol-3-phosphate (G3P) and closely related proteins from archaea and bacteria. Under phophate starvation conditions, Escherichia coli can utilize G3P as phosphate source when exclusively imported by an ATP-binding cassette (ABC) transporter composed of the periplasmic binding protein, UgpB, the transmembrane subunits, UgpA and UgpE, and a homodimer of the nucleotide binding subunit, UgpC. Members of this group belong to the type 2 periplasmic-binding fold superfamily. PBP2 proteins are comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	7.01547e-53
CP033073.1|AYN42804.1|7207972_7208473_-|peptidyl-prolyl-cis-trans-isomerase	gnl|CDD|238901	cd01920, cyclophilin_EcCYP_like, cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these have reduced affinity for cyclosporin A. E. coli cyclophilin A has a similar peptidylprolyl cis- trans isomerase activity to the human cyclophilin A. Most members of this subfamily contain a phenylalanine residue at the position equivalent to Human cyclophilin W121, where a tyrptophan has been shown to be important for cyclophilin binding.	6.75882e-85
CP033073.1|AYN42801.1|7205265_7206288_-|DSD1-family-PLP-dependent-enzyme	gnl|CDD|143487	cd06812, PLPDE_III_DSD_D-TA_like_1, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1. This subfamily is composed of uncharacterized bacterial proteins with similarity to eukaryotic D-serine dehydratases (DSD) and D-threonine aldolases (D-TA). DSD catalyzes the dehydration of D-serine to aminoacrylate, which is rapidly hydrolyzed to pyruvate and ammonia. D-TA reversibly catalyzes the aldol cleavage of D-threonine into glycine and acetaldehyde, and the synthesis of D-threonine from glycine and acetaldehyde. DSD and D-TA are fold type III PLP-dependent enzymes, similar to bacterial alanine racemase (AR), which contains an N-terminal PLP-binding TIM barrel domain and a C-terminal beta-sandwich domain. AR exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Based on their similarity to AR, it is possible members of this family also form dimers in solution.	4.637e-154
CP033073.1|AYN42816.1|7218823_7219810_-|sugar-ABC-transporter-permease	gnl|CDD|224096	COG1175, UgpA, ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism].	2.32302e-60
CP033073.1|AYN42818.1|7221358_7223380_+|beta-galactosidase	gnl|CDD|367090	pfam02449, Glyco_hydro_42, Beta-galactosidase. This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	0
CP033073.1|AYN42800.1|7204241_7205210_-|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|235918	PRK07048, PRK07048, threo-3-hydroxy-L-aspartate ammonia-lyase.	9.12717e-158
CP033073.1|AYN42811.1|7215302_7215707_+|SseB-family-protein	gnl|CDD|377787	pfam07179, SseB, SseB protein N-terminal domain. This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon. This entry contains the presumed N-terminal domain of SseB.	6.37771e-09

Protein sequences

>CP033073.1|AYN42808.1|7212813_7213629_-|CAP-domain-containing-protein
MGQHRKTKHYRRIAITAAAIGAVGVPSVALACSEWPYGPDGQAQAAATNAPVGQWQYAHRHHHRNGLDAGVPQTTPAPAPRATIPASTTEMTTARPTAHPSTTKKATSPQPERTAAPGTPGPTTTPAAPASAVPAAPSAPKPTATASGATAEIVRLVNAERGKAGCQALTLNSTLTKAAQAHSADMAAHQNMSHTGSDGTSPGDRITSAGYDWSSYGENVAYGYSTAEQVMAGWMASPGHRANILNCSFQEIGVGLAQPGSYWTQDFATAR
>CP033073.1|AYN42807.1|7210992_7212756_+|sigma-70-family-RNA-polymerase-sigma-factor
MRTQHTVDTAALVNAARAGDPAAQDALVSSYLPLVYNIVGRALNGSVDVDDVVQETMLRALDALGDLRTPESFRSWLVAIAMNRVRAHWKDRQLAPGTVEEAADVADPGADFVDLTIVRLQLSGQRQETARATRWLEPDDREVLSLWWLECAGELTRAEVTAALGVPPQHTAVRVQRMKARLEAARVVVRALDTRPACGELRGVLDSWDGLPSALWRKRIARHARDCARCSGLWSGLLPAEGLLAGLALVAVSPALLAAARSATTGTTTAGMTTTGSAAPAAPDTETARSAADAGHAGYAGPAESGAGGAGDASAERAGLRGARRRTTAREEARRRRRNRRRAVGGAVVAACVAGGGLWYFGAGSGPHSGDAAAAHTTGAPVVDMAAPRAAETSSSPSPSPSSSASPSPSASHSKKASASKSPRPTGGSSTPKAERTARVKPSATRTAPPQTQPAPAPAPAGTVAQVVALVNKERAAAGCGPVTEDAQLDKAAQGHSDDMAARGFFDHTNPDGAGPGERITAAGYRWSTYGENIAQGQQTPQAVMDSWMHSPGHRANILNCSFKNLGVGVHNGSGGPWWTQDFGARL
>CP033073.1|AYN42806.1|7210065_7210764_+|DUF4232-domain-containing-protein
MQNRHTSRVTLTALAAVAATLSLTACQSASAAPAAGAPTAEAAASSTTSTTAPAAVTRPAAVTRPASATPSSAAPTSAVPVPAATASVCAAKALKVTAYQAADRPTGTGTGAAVVRFTNVSAKACVLRGHPTVAGAGNGSPQHSVPLTVTRKGTASTVRVAPGGKAWLKLTFVQVQGEGDGYCVSGATPSVFPTLVVGLPGAGAHQVALDDGQFAECDNKVTATAVSSVKPS
>CP033073.1|AYN42805.1|7208690_7209764_-|NAD(+)/NADH-kinase
MTVNRVGLVVHGGRAEAVAAARAVREWCDEHAVGCTDIDVWREGARHSAREEVDAAGDPDLVVTLGGDGTFLRGARLAAENDAMVLGVDLGRVGFLTEVPATAVRAALDAVRERQITVESRMLLTLRASCRLEVPAQMEALLRYGRGPLLPPPRVRTDCRAGGDWGVALNVTALNDVVVEKLARDRQVSVGVYLAGRLLAAYSADALLVATPTGSTAYSFAAGGPVVSPRVEGLVFTPVAPHMVFNRSVVAAPDEPIALRVLERSGQAAVSIDGQLRGVLSPGDWIGVYAAPRRLRAVRLGPTDFYGRLRERMNLTDAPAALADGVAAPLWPVTTPPPDDLAHLAMPPAPDDAPWPS
>CP033073.1|AYN42804.1|7207972_7208473_-|peptidyl-prolyl-cis-trans-isomerase
MSSVELNTNFGRIVLELNDAEAPKTVENFLTYVRNGHYDGTIFHRVIPGFMVQGGGFAPDMSQKPTLGAIQNEADNGLKNNAYTVAMARTSDPHSATAQFFINVSDNAFLNYTAKTPNGWGYAVFGRVTEGQDVVDSIKGVKTGSRQGHQDVPAEPVVIESAKVLG
>CP033073.1|AYN42803.1|7207126_7207906_+|thioesterase
MAERPGAQHQSWLRSFHQSTPGAPRLVCLPHAGGSASFYFAVSKALSPAVEVRAVQYPGRQDRYDEPLAGSVQELAQGVFRALDDGQDTPLALFGHSMGAMVGFELARLLEAAGRPPVTFFASGRRGPSLVRTETVHQGDDAQLIAEVTKLDGTDAALLEDEELQRMVLPVLRADYRAVETYRRAPGPRLSCPVVAMTGDADPRLTPDEARTWAEETDGAFELRVFPGAHFYLVAQQEAVLAEVRAALRRLGPATGAVA
>CP033073.1|AYN42802.1|7206298_7206946_-|transcriptional-regulator
MGDLADSAEEADEHLVREAEKIAVALGRMFPGLCEVVLHDLRTPRHAVRVIENNLPGRQVGDSVTELGLARIADPEFPSVLQNYPNRFPDGRPAKSTSIGIRNAAGDYIAALCLNLDVSVLSPVTLALSNLVATDTEHRDAPLETLRDRTARELRQAVEAHAAERAATPRSLGREDKRTLVRQLQRDGYFASRDAARTIADLLGVSRATVYNYAK
>CP033073.1|AYN42801.1|7205265_7206288_-|DSD1-family-PLP-dependent-enzyme
MTATPSSTTSSCTTSNATPSSAAPTLAGPDTPFAVVDVHRTRHDIARLRARADRLGVPLRPHVKTAKSLDAAALLHDGVPGPVTVSTLAETEVFAAAGYTDITYAVAIDPHKLPRVIALSRRGVTLRVLLDSTEQARCVAAAAREAGIAVPAQIEIDCDGHRGGLKPDAPELTGIGRVLDDAGCLDGVLTHAGESYFAHTDEERRLAARNERDSAVAAAGRLRAGGLPVRTVSVGSTPTAHAAEDLTGVTELRAGNYVFFDLVMAGLGVCTVDDLALSVVVTVIGHRPEYGWIITDGGWMAMSRDRGTAAQHRGYHVVDGSRSSAGVPVTEAFWPRVTGW
>CP033073.1|AYN42800.1|7204241_7205210_-|pyridoxal-phosphate-dependent-enzyme
MAAVPPVSFDDVREAAARLKGVVHRTPVLTSRTLNSLVGAEVFIKAENFQRAGAFKFRGAYNAAAQLPPRRLAKGIAAYSSGNHAQAIALAARELGTTAVILMPEDAPRSKREATAGYGAEVVTYDRYAQDRTALGHALAADRGLALIPPYDDPHVIAGQGTAALELLEETGPLDALVVPVGGGGLIAGSATTATALHPGIRVIGVEPEAGDDTKRSLESGTRVTVPVPRTIADGQALATPGEITFPVNQRLVDGISLVGDAEIVTAMRFAFERLKIVLEPSGATPLAALLAGRVDNPPRRIGLIASGGNIDTRRFTELLGC
>CP033073.1|AYN42799.1|7203791_7204052_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MSFLWAIIAGLIIGLLAKLVLPGRQPIPLWLTVIMGIIGAVAGNALATAFGVGDTGGIDWIRHIFQIGVAALLIAFVTPLWARRHA
>CP033073.1|AYN42809.1|7214240_7214558_+|DUF2795-domain-containing-protein
MGTAHSGVPDVLDALKDVSFPADKDRLLSAAREAGASDEVVEALRGIPAEEYGGREHVARAVRADPDLGHDATRRAERARHGGRPGVAQHLRDAPKTPIHEEFDR
>CP033073.1|AYN42810.1|7214775_7214985_+|hypothetical-protein
MLLAGDSPGCRVLSTALAALAVAAEVLVVADARTGVDDDLPVRTLRTMELYRPLIRVTSLAGLRAEAGP
>CP033073.1|AYN42811.1|7215302_7215707_+|SseB-family-protein
METPAHDDLPTPTPAQRALDALAVNAEDQTALDTLAQSEVLVPVPDDAVNGEGADASTVALPVLEQPGGDPIVPVFTSEGEMAELLPFVSRYRLIPLGALASQWPEEDLSLAIDGSSAHGLTLTSQGVRTLLVR
>CP033073.1|AYN42812.1|7215827_7216238_-|MarR-family-transcriptional-regulator
MAVKTAETRLEERWRDILTVHARTMCEIDRSLHPHGLGASDFEVLDILAAESTGAGDQCRVQNLVGRVHLSQSALSRLIGRLEKDGLVERSVCAEDRRGVWVALTPRGRALHAEVLPLQRAALRRMLAEQEVPSAG
>CP033073.1|AYN42813.1|7216311_7216662_-|glyoxalase
MTAGLQTIIYPVRDLDRAKALFSALLGVEPYADEPYYVGYKAAGQDVGLDPNGHAKGMTGPVPYWHVTDLDKRLAALVDAGAELLQDAQDVGGGRLIASVRDSDGNLVGLLQDPAA
>CP033073.1|AYN42814.1|7216893_7217925_-|LacI-family-transcriptional-regulator
MTMSHTGGRRRPPTIHDVAREAGVSRGTVSRVLNGGHYVSPAAQEAVDAAIRRTGYVVNRHARSLITGRSDSVGFLLTEPQERFFEDPNFNVLLRGCTQALAAHDVPLLLMLAGTQDERRRITRYITAGHVDGVLLVSSHSGDPVAEELREAGVPLVACGKPIGLGSKVSYVAADDRDGARDMVRHLLSLGRRRIGVVTGPLDTPGGVERLAGYREVLAEAGIAADERLVVSGDYSRASGEAGAERLLARTPDMDAVFVASDLMAQGVLAALHRAGKRVPDDVAVGGFDDSPAATAASPALTTIRQPWDRISTEMVRVLLAQLGGEDPAAVILPTELVRRDST
>CP033073.1|AYN42815.1|7217921_7218827_-|carbohydrate-ABC-transporter-permease
MSTLAVRKAAPAAGTTPGTAQGPPRRRRIALVPTVTLLCGAVYTLLPVAWVVIASTKSGHELFSTFTFLPGTGFAGNLADLNAYRDGVYWTWMGNSALYAGLGALLSAAVSAVSGYALATYRFRGRETMFNVLLAGVLMPPVILAIPQYLLLAKADLTDSYLSVLLPQILSPYGVYLARVYASGAVPADVVEAGRMDGAGEWRIFTRIALPMMIPGMVTVFLFQFVAIWNNFLLPYIMLSDDEKFPLTLGLYTLLEQGSNTPALYTLVITGAFLAVLPLIALFLVIQRFWSLDLLSGAVKS
>CP033073.1|AYN42816.1|7218823_7219810_-|sugar-ABC-transporter-permease
MSSSASRTSYGAEGAPYGHPSPRTVRRARSAPYVFLVPATLLFALFFALPIGYAVWLSFRKVHVSGLGLGSGARTEVWAGLQNYTEAFQDSELLRGALRVLGYGCVVVPVMLGLALLFALMLDSEKVRLAPVTRLAIFLPYAIPGVVAALLWGFLYLPDVSPFYFVLDRLGLPQPDLLDGGPLFLALSNIAVWGGTGFNMIVIYTSLRSIPAEVYEAAKLDGATPTQIALRIKIPMVAPSLVLTFFFSIIATLQVFNEPTTLKPLTNSVSTTWSPLMKVYQDAFGRNDIYSAAAEATLVAVVTLLLSFGFLRAANRRTKRDVSQGEAG
>CP033073.1|AYN42817.1|7219806_7221123_-|extracellular-solute-binding-protein
MPHTKRRRLVTTALAVSLGATALAGCGSEDGSKTESGPVSLTYWTWTPGMDKVVDLWNKGPGKKNRISVTVKKQASGDTLVTKILTAHKAKKAPDLVQAEYQALPTLVSNDALADISQEVGGAKDKFADGVWQQTTLGTDAVYAVPQDIGPMMFYYRQDLFEKYGMKVPTTWEQFAETARELKKKAPDKDLTTFSANDSGLFAGLAQQAGAKWWTTSGDKWKVAIDDAATRKVAGFWGGLVKEGVIDNQPMYTPSWNKALDTGKQIAWVSAVWAPGTLTTAAPDTKGKWAMAPLPQWSLDQDATGSWGGSSTAVTTDSAHQKAAAEFATWLNTDHDALNALAEESGIYPASTSAQLSGAFSNPPAFFANQPDFYTRAAAVAKTTAPSAWGPNVNVAYTSFKDAFGAAAKNKSDFTAALRTMQDDTVADMKKQGFEVSR
>CP033073.1|AYN42818.1|7221358_7223380_+|beta-galactosidase
MPDISPRGLTRLAFGGDYNPEQWPESVWQEDVRLMREAGVTMVSVGIFSWALLEPAPGEYDFGWLDRVIDLLHDHGIRVDLGTPTVVPPVWFYRAHPEALPVTAEGVRYEFGSRGAICHSNADYRAAAAAITTALAERYGDHPALAMWHVHNEYGVPVSACYCDSCAAHFRRWLADTYGTVDAVNEAWGTAFWGQRYTGFEQINPPRATPTVGNPGQALDYRRFADATVRENFRAERDLLHRLSPGVPVTTNFMTALSQCDSMDYWAWGREVDLVTNDHYLITDGRRTHVNLAMAADLTRSVAGGAPWLLLEHSTSGVNWQPRNPAKAPGEMARNSLAHVARGSEGAMFFQWRQSRRGAEKFHSAMLPHGGTDTRVWREVVELGASIDTLSALGGTRTEADVAMLWDWQSWWAQNLAWRPSEDHDPRERADSFYEALYDHHLTVDFAHPEADLSAYPLVVVPALYLMTQAAGDNLRRYAENGGTLVVSYFSGIVDEHDAVHEGACPGVLRDVLGLTVEEFSPLLKDERVRLTAPDGPALTGDVWSEFVVPRGAETVWTYADGLTAGRPAVTRHRTGRGTAWYVSTRLDAQGLDAVLARAAGDAGIAPRADLPRDVEVVRRSGTSGTYLFAVNHTAGDTEVPLDTPGTELLTGERAAGRLAVPAGAVRVVRLDG

Crispr_ID: CP033073_18

• CRISPR_ID: CP033073_18
• CRISPR_location: 7281010-7281086
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP033073_18

Consensus_repeat	Method
CACGGAGGAACACGCGTGAACGCC	CRISPRCasFinder

spacers of CP033073_18

>18.1|7281034|29|CP033073|CRISPRCasFinder
GCGCACACGCCCTTGGTCGTCGTAGCCCG

CRISPR arrays and Neighbor proteins around CP033073_18

CRISPR arrays

The CRISPR arrays of CP033073_18

>merge|CP033073|18|7281010-7281086|CRISPRCasFinder
CACGGAGGAACACGCGTGAACGCCGCGCACACGCCCTTGGTCGTCGTAGCCCGCACGGAGGGACACGCGTGAACGCC

>CP033073|18|18|7281010-7281086|CRISPRCasFinder
CACGGAGGAACACGCGTGAACGCC	GCGCACACGCCCTTGGTCGTCGTAGCCCG
CACGGAGGGACACGCGTGAACGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN44007.1|7288800_7289175_+|ferredoxin	unknown	unknown	unknown
CP033073.1|AYN42859.1|7273802_7275437_+|carbamoyltransferase	unknown	unknown	gnl|CDD|225103
CP033073.1|AYN42857.1|7271489_7272053_-|hemerythrin-domain-containing-protein	unknown	unknown	gnl|CDD|376622
CP033073.1|AYN42870.1|7291034_7292531_+|acyl-CoA-synthetase	unknown	unknown	gnl|CDD|181381
CP033073.1|AYN44006.1|7282608_7283730_+|glycosyltransferase-family-9-protein	unknown	unknown	gnl|CDD|340821
CP033073.1|AYN42866.1|7285721_7286225_+|anti-sigma-factor-antagonist	unknown	unknown	gnl|CDD|132914
CP033073.1|AYN42871.1|7292680_7293997_-|phenylacetate--CoA-ligase	unknown	unknown	gnl|CDD|131210
CP033073.1|AYN42853.1|7265889_7266318_-|hypothetical-protein	unknown	unknown	gnl|CDD|377188
CP033073.1|AYN42854.1|7266310_7267306_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42856.1|7271071_7271401_+|DUF3040-domain-containing-protein	unknown	unknown	unknown
CP033073.1|AYN42872.1|7294253_7295120_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
CP033073.1|AYN42861.1|7276425_7277094_+|HAD-IIIA-family-hydrolase	unknown	unknown	gnl|CDD|319806
CP033073.1|AYN42862.1|7279058_7280291_+|glycosyltransferase-family-1-protein	unknown	unknown	gnl|CDD|340830
CP033073.1|AYN42860.1|7275433_7276429_+|glycosyltransferase	unknown	unknown	gnl|CDD|133029
CP033073.1|AYN42869.1|7289255_7290821_+|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224154
CP033073.1|AYN42865.1|7283719_7284661_+|glycosyltransferase	unknown	unknown	gnl|CDD|133029
CP033073.1|AYN42858.1|7272766_7273774_+|NAD-dependent-epimerase/dehydratase-family-protein	unknown	unknown	gnl|CDD|187541
CP033073.1|AYN42867.1|7287750_7288206_+|RpiB/LacA/LacB-family-sugar-phosphate-isomerase	unknown	unknown	gnl|CDD|376799
CP033073.1|AYN42868.1|7288285_7288636_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42855.1|7267479_7270548_+|hypothetical-protein	unknown	unknown	gnl|CDD|238121

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN42870.1|7291034_7292531_+|acyl-CoA-synthetase	gnl|CDD|181381	PRK08316, PRK08316, acyl-CoA synthetase; Validated.	0
CP033073.1|AYN42859.1|7273802_7275437_+|carbamoyltransferase	gnl|CDD|225103	COG2192, COG2192, Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones].	3.76236e-168
CP033073.1|AYN42857.1|7271489_7272053_-|hemerythrin-domain-containing-protein	gnl|CDD|376622	pfam01814, Hemerythrin, Hemerythrin HHE cation binding domain. Iteration of the HHE family found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor hemerythrin binds Cadmium so as to protect the organism from toxicity. However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial NorA is a regulator of response to NO, which suggests yet another set-up for its metal ligands. In Staphylococcus aureus the iron-sulfur cluster repair protein ScdA has been noted to be important when the organism switches to living in environments with low oxygen concentrations; perhaps this protein acts as an oxygen store or scavenger.	1.65408e-11
CP033073.1|AYN44006.1|7282608_7283730_+|glycosyltransferase-family-9-protein	gnl|CDD|340821	cd03789, GT9_LPS_heptosyltransferase, lipopolysaccharide heptosyltransferase and similar proteins. Lipopolysaccharide heptosyltransferase (2.4.99.B6) is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from ADP-heptose to 3-deoxy-D-manno-octulosonic acid (KDO), a part of the inner core component of LPS. This family also contains lipopolysaccharide 1,2-N-acetylglucosaminetransferase EC 2.4.1.56 and belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.	3.54804e-43
CP033073.1|AYN42871.1|7292680_7293997_-|phenylacetate--CoA-ligase	gnl|CDD|131210	TIGR02155, Phenylacetate-coenzyme_A_ligase, phenylacetate-CoA ligase. Phenylacetate-CoA ligase (PA-CoA ligase) catalyzes the first step in aromatic catabolism of phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Often located in a conserved gene cluster with enzymes involved in phenylacetic acid activation (paaG/H/I/J), phenylacetate-CoA ligase has been found among the proteobacteria as well as in gram positive prokaryotes. In the B-subclass proteobacterium Azoarcus evansii, phenylacetate-CoA ligase has been shown to be induced under aerobic and anaerobic growth conditions. It remains unclear however, whether this induction is due to the same enzyme or to another isoenzyme restricted to specific anaerobic growth conditions. [Energy metabolism, Other].	0
CP033073.1|AYN42853.1|7265889_7266318_-|hypothetical-protein	gnl|CDD|377188	pfam03995, Inhibitor_I36, Peptidase inhibitor family I36. This domain is currently only found in a small set of S. coelicolor secreted proteins. There are four conserved cysteines that probably form two disulphide bonds. Proteins 2SCK31.15C and SCO3675 also have probable beta-propellers at their C-termini. This family includes Streptomyces nigrescens SmpI, a known peptidase inhibitor of known structure. This protein has a crystallin like fold pfam00030 and is distantly related by sequence. It is not known whether other members of this family are peptidase inhibitors.	0.000210081
CP033073.1|AYN42866.1|7285721_7286225_+|anti-sigma-factor-antagonist	gnl|CDD|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	1.4305e-07
CP033073.1|AYN42872.1|7294253_7295120_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	4.1922e-22
CP033073.1|AYN42861.1|7276425_7277094_+|HAD-IIIA-family-hydrolase	gnl|CDD|319806	cd07503, HAD_HisB-N, histidinol phosphate phosphatase and related phosphatases. This family includes the N-terminal domain of the Escherichia coli bifunctional enzyme histidinol-phosphate phosphatase/imidazole-glycerol-phosphate dehydratase, HisB. The N-terminal histidinol-phosphate phosphatase domain catalyzes the dephosphorylation of histidinol phosphate, the eight step of L-histidine biosynthesis. This family also includes Escherichia coli GmhB phosphatase which is highly specific for D-glycero-D-manno-heptose-1,7-bisphosphate, it removes the C(7)phosphate and not the C(1)phosphate, and this is the third essential step of lipopolysaccharide heptose biosynthesis. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.06522e-55
CP033073.1|AYN42862.1|7279058_7280291_+|glycosyltransferase-family-1-protein	gnl|CDD|340830	cd03800, GT4_sucrose_synthase, sucrose-phosphate synthase and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.	4.43947e-142
CP033073.1|AYN42860.1|7275433_7276429_+|glycosyltransferase	gnl|CDD|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	1.53294e-23
CP033073.1|AYN42869.1|7289255_7290821_+|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	9.19066e-67
CP033073.1|AYN42865.1|7283719_7284661_+|glycosyltransferase	gnl|CDD|133029	cd04186, GT_2_like_c, Subfamily of Glycosyltransferase Family GT2 of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.	4.79808e-27
CP033073.1|AYN42858.1|7272766_7273774_+|NAD-dependent-epimerase/dehydratase-family-protein	gnl|CDD|187541	cd05230, UGD_SDR_e, UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs. UGD catalyzes the formation of UDP-xylose from UDP-glucuronate; it is an extended-SDR, and has the characteristic glycine-rich NAD-binding pattern, TGXXGXXG, and active site tetrad. Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids. Extended SDRs are a diverse collection of proteins, and include isomerases, epimerases, oxidoreductases, and lyases; they typically have a TGXXGXXG cofactor binding motif. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	4.39861e-160
CP033073.1|AYN42867.1|7287750_7288206_+|RpiB/LacA/LacB-family-sugar-phosphate-isomerase	gnl|CDD|376799	pfam02502, LacAB_rpiB, Ribose/Galactose Isomerase. This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).	2.2393e-35
CP033073.1|AYN42855.1|7267479_7270548_+|hypothetical-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	1.71098e-79

Protein sequences

>CP033073.1|AYN42862.1|7279058_7280291_+|glycosyltransferase-family-1-protein
MSRIPHTAGRVAMVSEHASPLAALGGPDAGGQNVYVAQVARQLARKGYRVTVYTRRDSAGLPDRVTLIDGVQVVHVPAGPPAAVPKDELLPYMTEFGNFLARQWTQNPPDVVHAHFWMSGLAALAGARERGIPVVQTYHALGTVKQRYQGAADTSPPQRLAIEEAIGHECTRIIATCSDEVAELKAMGLPEDRISVVPCGVDPDQFAPVGRPRRAGTRRRLLAVGRLVPRKGYDRAIRALAGVPDAELLVAGGPEADLLGTEPEAARLYGIAAELGVADRVTLLGGVGRARMPRLMSSADLVLSLPRYEPFGIVPLEAMSCATPVVATAVGGQLDTVVDGTTGVLVPADDDHDLGAVVRTLLADPDRLARYGAAGRERVLSHYTWDRVADGVAGVYGAVSSVRSLSGVVR
>CP033073.1|AYN42861.1|7276425_7277094_+|HAD-IIIA-family-hydrolase
MSRLSAILFDRDGTLVQDVPHNGDPGRVRLLPGAAAAVALARSAGLPTAVVSNQSGIGRGLLTVDQVRRVNERADELLGGLDTWVFCPHTPDAGCVCRKPRPGLIRTAAARLGVEPAGCLVIGDIAADVLAARAAGARGVLVPNAATAPAETARFATDSAPDVLTAVRAALAEAGIPAGGRTPARPPSDGRTPTREPRPTPTPPASPAAPTTPAAPVGRRSL
>CP033073.1|AYN42860.1|7275433_7276429_+|glycosyltransferase
MTDAPAYTVVVPTIGRPCLAECLRALAAAGDHPPHEVVVVDDRPAPDGGLPLEPAGQLLDRVRTLRTGGRGPAAARNAGWQTVRTPWTVFLDDDVQVLPDWSRRLAEDLREAGPDVGGIQGHLRVPLPPDRRPTDWERTTKGLENAAWATADMAYRTEALKRTGGFDERFPRAFREDADLALRVQRAGWSLVRGGRVTRHPVRPAHWWASLPVQRGNADDALMNRLHGRDWWDRAQAPRGRLPRHLAVTAAALAAASCALTGRRRAATAWAALWTLGTTEFALARILPGPRTAREIARMLGTSVLIPPLAVRHWVRGVVRHRHAEPLGGAR
>CP033073.1|AYN42859.1|7273802_7275437_+|carbamoyltransferase
MHVLGINALFHDPAAALITDGKVVAAAEEERFSRRKHGKRPVPFSAWELPEQSARWCLAQTGLTPSDLDAVAYSYDPALARTAERLGLHDPWDHLRQEYARQAPQFLAEALPGLDPAKVRFVPHHVAHAASAGAVSPYPDCAVLVLDGRGECGSHLAGRYTGRELTVLGAQELPDSLGLFYEDLTQHLGFLRSSDEFKVMALASHGTPRFAGRLREYVHAEDGGGFRARPVPWAEFVPPRPAHGAWDQDHADLAASAQLCLEEAMLALARWLRERTGEDVLTLAGGVALNCVANTRLWRESGFAHVWVQPAAGDAGTALGAAAHVAGQKDTLEPMPTAALGRGWNDAELREWLERAAVPYEEPADIAETAAEALAADGIVAWFQGRSEYGPRALGHRSLLAHPGRAANLERLNAVKGREEFRPVAPMVLAERAAEIFDGPLPSPHMLFVHDVAPDWRARIPAVVHVDGTARIQTVDRAQEPLVARMIEGFERRTGLPVVVNTSLNTAGRPMVDDPRDALECFGSAPVDLLVLGPFAIRRGKAFA
>CP033073.1|AYN42858.1|7272766_7273774_+|NAD-dependent-epimerase/dehydratase-family-protein
MTAETPFSWRRALVTGGAGFLGSHLCERLLDSGAEVDCADNLACGRRENVAHLEDRPGFRYVHCDVSTAGCTALLPGPYDLVLHFACPASPADYLRMPLETLDVGSLGTRNALTIAERDDARFLLASTSEVYGDPLVHPQHEGYWGNVNPVGPRSVYDESKRFGEALVTAHAGTRGTNAGIVRLFNTYGPRMRAHDGRAVPTFICQALAGEPLTVTGDGSQTRSLCYVDDTVDGILRVAASRSVRPVNIGGSEEITVADLARRVVALTGSRSPIAFIDRPVDDPGRRRPDTTLARELLGWSPQTPWEEGLKQTIAYFSALPPEPAPRTEVPAPQS
>CP033073.1|AYN42857.1|7271489_7272053_-|hemerythrin-domain-containing-protein
MGHGGNVIQELTTDHREVEEFFGRIEALPPGSSERKNLADQATIELVRHSVAEEAYLYPAVREHLTGGDALADKELEDHAKAEQIMKDLEGCQADDPRFDTLMAQLMTEIRSHVADEEQNLFPRLEAACSADALMTLGDKVRRAKKTAPTRPHPAAPDKPPANKLLAPGAGLVDRMRDALSGRGRES
>CP033073.1|AYN42856.1|7271071_7271401_+|DUF3040-domain-containing-protein
MDDWEMHDEVRLSPRERLALVQIESGLRQDRRFARRMGCPRGPGWLPAAVVLLTAASVFVAVMGIRTSDPALLWCFAWLWPLTLLQVFRLLCRATRTRSRSGARVTPWL
>CP033073.1|AYN42855.1|7267479_7270548_+|hypothetical-protein
MGSMARKERPLEGEDGPLLRFAAALRRLRHEAGSPPYRDLAHRAHYSVATLSGAASGRRLPSLDVTLSYVRACGGDPREWEARWHAVAVELRTESCAGPPQERNGPEGTGSPHGQPCPEVPEGPLRGPYVGLAAFRTEDADLFFGRERLVEDLLATLARRRAVALVGASGAGKSSLLSAGLLPRLAGDEPRRTVRVLTPGPNPRERLEKALAAKPGSGPGCGSGSGMGSGSRSRSGSGPGSGSESGTARGPVSGPGSEAGELVLVVDQFEEVFTVCTDADERARFIAALVEEAERPGSGCRIVLGVRADFYAHCTRHAPLVAILRDAQVVVGPMSAAELRCAVVEPARRAGLTVEGALQATLVAHAHGQAGVLPLLSHALLETWRRRRGAALTLDGFHAAGGFEGALAQSAESLHSSLTERQQWSARQIFVHLIALGEGTEDTKRPVSREELGEDADTATVLARAVALRLLTLDDGRVELTHEALIRAWPRLRGWLTDDRERLRTHRQLTDAARTWETLGRDPGALYRGARLALARDLLTSRDIRLAPSEQAFVDAGTAAEAAAGNSARRRARRLRTLVALLAVLVVVAAIATVNARHAEDEVTRQRNDAVAQIIADSATGLIDTDPGLAVQLGLTAYRLAPTTRTRDALVSTLMTTVRAHAKEVLAIAYRPDGRQLATASGDHTARLWRVHGTDRPVAEATLSGHGDDVRTVVYRPDGRALATGSADGSVRLWDTATPTRPALLASLTGQGGDVRSLAYDPDGRTLATAGTDGSVGLWDVTDPATPALLTRVTGHRDAVRAVAFSPDGRTLASAGEDGAVRLTAIADPRRPRRLAVLDGHGTGAFSVAFSPDGRTLATAGGGHDPVRLWGLADPRRPAPLAGLSGHTDVVGSVAFSPDGRTLASASDDRTVRLWNVVRPAHPTALTTLTGHSTAVSSVAFSPDGTVLASGGFDATVRLAGTDRARVIAHACAHTGPRITRAQWAAHLRYVAYAPPCGRPDDSAAISRPRHGPDADGSDRRP
>CP033073.1|AYN42854.1|7266310_7267306_-|hypothetical-protein
MRRHRATAMTAAHAVAAGLATVLLLGGCGAATGGPAPGPHPAGSSREPSPRETRVLDRAEQVLISRCMAARGWRYEVTEAGGASGEGARSFPYAVDDVAWARAHGYGGREERLRTEARRADPNQRYFHRLSPSARAAARTALMGSSAVGLSVKAPTDMTITASTEGCIADAERTLYGDLEDWFRVKVVTMNLRPVREARVRRDRRYVTAVGRWAACMRAAGRPYADPDESRQAAARYGESLPAAEADAAGTALAVTEATCATGTPLARVSRALDRSYGERLRTQYREELVDRWRFQNAALPMARRLAPPSPSAPPSSHEPGETETSGGSHA
>CP033073.1|AYN42853.1|7265889_7266318_-|hypothetical-protein
MRKFRTMLLAGTFVLPLLAVPATLTTAHAATADTAAASASGLAADGAYWVWEDTNRGGHSCGWSGNDANWSTCGPNGSFNMNDRASAWWNNGYGGAYGDVRVYEDINYGGASTCAPNGGQGNIPWEWNDRISSHKWVTACGY
>CP033073.1|AYN44006.1|7282608_7283730_+|glycosyltransferase-family-9-protein
MRGRPAGRSRLRRRPGDGSPGPGPAPRRTHVPFHRRISSVSTEHFASPSDAPRVLVLRALGLGDLLAGVPALRGIRRAFPGHRIVLAQPPGLSELALATAAVDAVLPAEAPDRAVPQLTHWSGPPPDVAVDLHGNGPESRDALAALHPRRLLAHACPDGPPWPAQANERDRWCAFLHGYGIPADPLDLRLPRPATPSPAPGAVVVHPGAASGSRRWPGERFAAVVRCLRAAGHHVVLTGGPGEDALVRSVAERSGRRAGDVLTGGLPFARLSALVAEASLVLSGDTGLAHLAVAHGTRSVTLFGPVSPRLWGPPPSPDHVALWKPGPPGDPHGRAPDARLLRVRTGEVAAACLTLLRDVRGGQRQDGEAAHVH
>CP033073.1|AYN42865.1|7283719_7284661_+|glycosyltransferase
MSTEHAPGRVRGTPAGRDPRVTVAVITRDRSASLLRTLDALAALPERPPVVVVDNSRDDTTYRAVAGHPAITRLLRPAVNTGALGRNLAARHARTPYVAFSDDDSWWEPGSLARAADLLDRHPRLGLLAARTLVGPEATEDPLNAVLAASPLPPEPDLPGRPVLGFLGCACVVRREAFLGVGGYHPLLFFGGEETLLAYDLAAAGWGVTYEPSLSACHHPEDHGRTGRSSLVRRNAVLTTCLRRPWPVAVRAGTGLALAAAAGRPGARDALRETLTRFPAALARRRTLPPHVERAARLLDREPAGGPRRGAPR
>CP033073.1|AYN42866.1|7285721_7286225_+|anti-sigma-factor-antagonist
MESRSLTDSGQPPPARVRPGGPAPLLLQTVHEHRPGLGAISVLKARGTVDDSNARQFAEALAEHVGHAGQAAEHPLLDLTEVYFACAAAVRCLERATGPLARAGRALAVVQPRPHVREALSNAGLPGVRVHATLVSALHALHAPRQPHPAHPPADRETAGAEPGDPT
>CP033073.1|AYN42867.1|7287750_7288206_+|RpiB/LacA/LacB-family-sugar-phosphate-isomerase
MRISVSSDMDEPVARLLVAELRRRGHDVREHGALRPGADARWAACSEAAARDVAEAAADQAVVCCWTGTGASIAANKVPGVRAALCTDAATAEGARRWNDANVLALSLRLISEPVLKEILDAWFAAEPSQDAEDRQNVARVGRLDATRKGS
>CP033073.1|AYN42868.1|7288285_7288636_-|hypothetical-protein
MQLAAASGLMSLFLFIVAVALLALLGGGFWMTSRVKYREPPRPRPDEQPKLPPEGAVHEVRQNRESAEVPQTSKGGRPLTPYELTNMDSQPSESEERPRWSRGSSGSFGGGGLGAH
>CP033073.1|AYN44007.1|7288800_7289175_+|ferredoxin
MTPPTSQQQLYRFLEDRFTCAQACTECARTCAVRASLVEPDGTERQERVRRIGIMCAEVCDATCRVLCEENRQDEETLRVRVEWCRSVCLECAHAFDDHPGAEPAAAVCRGCADACAGFLEMLN
>CP033073.1|AYN42869.1|7289255_7290821_+|NAD(P)/FAD-dependent-oxidoreductase
MSANEGTRAYDAVIVGGGHNGLVAAAYLARAGRSVLVLERLDHTGGAAVSTRPFTGLDARLSRYSYLVSLLPTKIVRDLGLDFRVRTRGISSYTPTERDGRPTGLLVGGGEQRTRESFARLTGGDREYEAWQRFYGMTGRVAQRVFPTLTEPLPTRDELRRRIDDEAAWRALFEEPVGVAVEDTFHDDLVRGVVLTDALIGTFADAHDPSLAQNRCFLYHVVGGGTGAWDVPVGGMGALTGALAAAARAAGAEIATGHEAVRIHTDGNTAEVAYRTRDGEGAAAARHVLVNASPRELAALTGDPAPEAAEGAQFKVNMLLTRLPGLRDPGVDPREAFAGTFHIAEGYRQLATAHAQAAAGELPAAPPSEIYCHSLTDPTILGPDLAERGYQTLTLFGLHTPARLFDRDNDAVREELLKSTLGQLDAHLAEPLADCVATDADGRPCIEAKTPLDLERDLRLPGGHIFHRALSWPYAQQETGRWGVETGHPGVLLCGAGAVRGGGVSGVPGHNAAMAVLEANT
>CP033073.1|AYN42870.1|7291034_7292531_+|acyl-CoA-synthetase
MTQGHGSTVDGVLRRSARRTPARLAVEYGERGWTYGELDDAVSRAASLLRAEGLAPGDRVASYGHNSDACLIAFLACSRAGLIHVPVNHGLTGADLAHILGESGSTLVLADPDLAGRLPRDARVLALRDTDDSLLTRLPQAPPYDGPEPRTEDLAQLLYTSGTTALPKGAMMTHRALVHEYLSAITALDLSAGDRPVHALPLYHSAQLHVFLLPSLAVGATNVILDAPDGDRLLDLIETGRVDSLFAPPTVWIGLAGRPDFATRDLGGLRKAYYGASVMPVPVLERLRRHLPHLAFYNCFGQSEIGPLATVLGPDEHEGRLDSCGRTVLFVDARVVDDDGADVPDGTPGEIVYRSPQLCEGYWDRPEETAEAFRDGWFHSGDLAVRDSDGYFTIVDRVKDVINSGGVLVASRQVEDALHTHEAVAEAAVIGLPDERWIEAVTAVVVPCGEVTGDQLIAHVKGRLTPFKAPKRVLFVDALPRNASGKILKRELRDRFTA
>CP033073.1|AYN42871.1|7292680_7293997_-|phenylacetate--CoA-ligase
MADARDLLDAGERLGPEELRALQLERLRASLRHAYEHVPFYRESFDKAGVRPEDCRSLADLAQFPLTTKSDLRENYPYGMFAVPRERIRRLHASSGTTGRPTVVGYTDNDLSMWADMVARSIRAAGGRPGDIVHVAYGYGLFTGGLGAHYGAERLGCTVVPASGGMTARQVRLIRDLEPSVVMVTPSYMLTLLDEFERQGVDPRGTSLRAGVFGGEPWTEQMRREIEERFAIDAVDIYGLSEVIGPGVAQECAETKDGLHVWEDHFYPEVVDPITGEVLPEGERGELVFTSLTKEAMPIVRYRTRDLTRLLPGTARVFRRMEKVTGRSDDMVILRGVNLFPTQIEEIVLRTPGVAPHFQLRLTRKGRLDALTVRAEARPGATPEARDAAARSIVAAVRDGVGVSVGVEIVEPESLERSVGKIRRIVDLRPRDAGHVST
>CP033073.1|AYN42872.1|7294253_7295120_+|alpha/beta-hydrolase
MPAFSTADGTRLAYHLRGTGEPLAVLPGGPMRASAYLGDLGGLAAVRRLALLDLRGTGNSATPADPATYRCDRMVEDVEAWRAHMGLEHMDLLAHSAGAALALLYAARHPHRIRRLVLVTPNPSPLGMRATPEDRLAAARLRADEPWFARAYPAFRAWLADGADFDDTFLPFFYGRWNDTARAHADAEPGQTNDEAGDRYFAEGAFDPDATRTALAALTAPVLVYAGGADGGPCPDLAHRTARALPDAEVAVQPGAGHYPWLDDPRWFRGRVAAFLGTPADTPRTPAR

Crispr_ID: CP033073_19

• CRISPR_ID: CP033073_19
• CRISPR_location: 7385901-7385988
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP033073_19

Consensus_repeat	Method
CCGCGCGGCGACGCGACACGGACCGGCCGA	CRISPRCasFinder

spacers of CP033073_19

>19.1|7385931|28|CP033073|CRISPRCasFinder
AGGGCCTCACCCGGGGGAGCGGCATGCT

CRISPR arrays and Neighbor proteins around CP033073_19

CRISPR arrays

The CRISPR arrays of CP033073_19

>merge|CP033073|19|7385901-7385988|CRISPRCasFinder
CCGCGCGGCGACGCGACACGGACCGGCCGAAGGGCCTCACCCGGGGGAGCGGCATGCTCCGCGCGGCGACGCGACACGGCCCGGCCGA

>CP033073|19|19|7385901-7385988|CRISPRCasFinder
CCGCGCGGCGACGCGACACGGACCGGCCGA	AGGGCCTCACCCGGGGGAGCGGCATGCT
CCGCGCGGCGACGCGACACGGCCCGGCCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN42943.1|7382373_7383003_-|alpha-ketoglutarate-dependent-dioxygenase-AlkB	unknown	unknown	gnl|CDD|225687
CP033073.1|AYN42952.1|7392217_7393105_-|LysR-family-transcriptional-regulator-ArgP	unknown	unknown	gnl|CDD|235144
CP033073.1|AYN42946.1|7385489_7385840_-|DUF488-family-protein	unknown	unknown	gnl|CDD|225730
CP033073.1|AYN42942.1|7381503_7382271_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293807
CP033073.1|AYN42953.1|7393171_7393786_+|amino-acid-transporter	unknown	unknown	gnl|CDD|224198
CP033073.1|AYN42937.1|7375689_7376040_-|hypothetical-protein	unknown	unknown	gnl|CDD|366940
CP033073.1|AYN42940.1|7379381_7380248_+|universal-stress-protein	unknown	unknown	gnl|CDD|366180
CP033073.1|AYN42945.1|7383812_7385486_+|FAD-binding-dehydrogenase	unknown	unknown	gnl|CDD|183782
CP033073.1|AYN42939.1|7377484_7379161_-|response-regulator	unknown	unknown	gnl|CDD|381126
CP033073.1|AYN42948.1|7387550_7388285_+|hypothetical-protein	unknown	unknown	gnl|CDD|226309
CP033073.1|AYN42938.1|7376036_7377488_-|histidine-kinase	unknown	unknown	gnl|CDD|340419
CP033073.1|AYN42947.1|7386099_7387509_+|M1-family-peptidase	unknown	unknown	gnl|CDD|341066
CP033073.1|AYN42949.1|7388305_7389010_+|DNA-binding-response-regulator	unknown	unknown	gnl|CDD|223816
CP033073.1|AYN42955.1|7395220_7395676_-|hypothetical-protein	unknown	unknown	gnl|CDD|237999
CP033073.1|AYN42944.1|7383136_7383763_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
CP033073.1|AYN44013.1|7395949_7396192_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN42951.1|7391477_7391729_-|WhiB-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376791
CP033073.1|AYN42941.1|7380257_7381493_-|DUF4032-domain-containing-protein	unknown	unknown	gnl|CDD|379077
CP033073.1|AYN42950.1|7389035_7390883_+|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|274368
CP033073.1|AYN42954.1|7393871_7395170_+|MFS-transporter	unknown	unknown	gnl|CDD|340863

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN42943.1|7382373_7383003_-|alpha-ketoglutarate-dependent-dioxygenase-AlkB	gnl|CDD|225687	COG3145, AlkB, Alkylated DNA repair protein [DNA replication, recombination, and repair].	4.89876e-31
CP033073.1|AYN42952.1|7392217_7393105_-|LysR-family-transcriptional-regulator-ArgP	gnl|CDD|235144	PRK03635, PRK03635, ArgP/LysG family DNA-binding transcriptional regulator.	2.67754e-146
CP033073.1|AYN42946.1|7385489_7385840_-|DUF488-family-protein	gnl|CDD|225730	COG3189, COG3189, Uncharacterized conserved protein [Function unknown].	3.14315e-42
CP033073.1|AYN42942.1|7381503_7382271_-|MBL-fold-metallo-hydrolase	gnl|CDD|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	8.08755e-42
CP033073.1|AYN42953.1|7393171_7393786_+|amino-acid-transporter	gnl|CDD|224198	COG1279, COG1279, Lysine efflux permease [General function prediction only].	1.55683e-57
CP033073.1|AYN42937.1|7375689_7376040_-|hypothetical-protein	gnl|CDD|366940	pfam02148, zf-UBP, Zn-finger in ubiquitin-hydrolases and other protein.	6.85379e-12
CP033073.1|AYN42940.1|7379381_7380248_+|universal-stress-protein	gnl|CDD|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	3.86202e-18
CP033073.1|AYN42945.1|7383812_7385486_+|FAD-binding-dehydrogenase	gnl|CDD|183782	PRK12834, PRK12834, putative FAD-binding dehydrogenase; Reviewed.	0
CP033073.1|AYN42939.1|7377484_7379161_-|response-regulator	gnl|CDD|381126	cd17595, REC_TrxB, phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain. This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	2.1167e-79
CP033073.1|AYN42948.1|7387550_7388285_+|hypothetical-protein	gnl|CDD|226309	COG3786, COG3786, Uncharacterized protein conserved in bacteria [Function unknown].	3.42251e-11
CP033073.1|AYN42938.1|7376036_7377488_-|histidine-kinase	gnl|CDD|340419	cd16943, HATPase_AtoS-like, Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS. This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.	2.67253e-49
CP033073.1|AYN42947.1|7386099_7387509_+|M1-family-peptidase	gnl|CDD|341066	cd09603, M1_APN_like, Peptidase M1 family similar to aminopeptidase N catalytic domain. This family contains mostly bacterial and some archaeal M1 peptidases with smilarity to the catalytic domain of aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease belonging to the M1 gluzincin family. APN preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and, in higher eukaryotes, is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation, thus considered a marker of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. APNs are also present in many pathogenic bacteria and represent potential drug targets. Some APNs have been used commercially, such as one from Lactococcus lactis used in the food industry. APN also serves as a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs have also been extensively studied as putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	4.68704e-171
CP033073.1|AYN42949.1|7388305_7389010_+|DNA-binding-response-regulator	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	7.22757e-76
CP033073.1|AYN42955.1|7395220_7395676_-|hypothetical-protein	gnl|CDD|237999	cd00038, CAP_ED, effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels.	1.12962e-17
CP033073.1|AYN42944.1|7383136_7383763_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	5.15287e-10
CP033073.1|AYN42951.1|7391477_7391729_-|WhiB-family-transcriptional-regulator	gnl|CDD|376791	pfam02467, Whib, Transcription factor WhiB. WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	6.81817e-27
CP033073.1|AYN42941.1|7380257_7381493_-|DUF4032-domain-containing-protein	gnl|CDD|379077	pfam13224, DUF4032, Domain of unknown function (DUF4032). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, and is approximately 170 amino acids in length. The family is found in association with pfam06293.	2.67166e-85
CP033073.1|AYN42950.1|7389035_7390883_+|HAMP-domain-containing-protein	gnl|CDD|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	2.34425e-64
CP033073.1|AYN42954.1|7393871_7395170_+|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.76548e-64

Protein sequences

>CP033073.1|AYN42946.1|7385489_7385840_-|DUF488-family-protein
MSVRLRRIYEPPEPDDGLRVLVDRLWPRGLAKDAARVDEWPKALTPSTELRRWYHAGEGGYEEFRRRYEAELGAPEAAALLDGLRDSARGGPVTLLTASKAPGKSHAHVLLDLLRS
>CP033073.1|AYN42945.1|7383812_7385486_+|FAD-binding-dehydrogenase
MDADVIVVGAGLAGLVAAHELTSRGRRVALVDQENAANLGGQAFWSFGGLFLVDSPEQRRLGIKDSFDLAWNDWHGSARFDRLEDEDTWAVRWARAYVEFAAGEKRSWLQGHGIELLPTVGWAERGDLRADGHGNSVPRFHIAWGTGTGVVEPFVRHARQAARDGLLTFHHRHRVDELLIEGGTARGVRGTVLTPDDSPRGAPSGRDRAGDFELTAQAVVVTTGGIGADHDIIRRYWPERLGTPPAEMVTGVPAYVDGRMLDISAEAGVRLVNRDRMWHYTEGLQNWDPIWPGHGIRILPGPSSVWLDALGRRLPDPCLPGYDTLGTLRHLRTTEDIAAYDHSWFVLTRKIIEKEFALSGSEQNPDITAKDRKAVLRDRLLGKGAPGPVRAFLDHGADFVTAGNLEQLVARMNALTGEDLLDAAEVRRQIEARDLQITNPYSKDAQVQGIRNARRYIGDRLGRVAAPHRILDPAAGPLVGVRLRVLTRKTLGGIQTDLDSRALGTDGTPIGGLYAAGEVAGFGGGGVHGYNALEGTFLGGCLFSGRAAGRHAAGLTA
>CP033073.1|AYN42944.1|7383136_7383763_+|TetR/AcrR-family-transcriptional-regulator
MENDTSGRRVTRRRGRTRARLLDAAFQVFAAKGFGRVAIEEVCEAAGYSRGAFYSNFATLDELFFALYRERADLIASQVADALAQDGPDLDVPASVDRVTEVLLLDVDWLLVKTDFLVHAARDPVVARTLLDHRTRLRRAVADRLLRARGHTELPAVLGDVDGAAHAVVAAYDGVTTQLLLDRDAEAARTWLKQLLTALLTDGSRIPA
>CP033073.1|AYN42943.1|7382373_7383003_-|alpha-ketoglutarate-dependent-dioxygenase-AlkB
MATHLQGSLFDQTDELRLGPLGGLRRTELDAGAWIDVLPGWLSGADTLFERLAADVPWRAERRAMYDHVVAVPRLLAFYGAADPLPHPVLDEARAALSRHYAEELGEPFTTAGLCLYRDGRDSVAWHGDRIGRGAREDTMVAILSVGAPRDLLLRPAGGGGGTLRRPLGHGDLIVMGGSCQRTWEHCVPKTTRATGPRISIQFRPHGVH
>CP033073.1|AYN42942.1|7381503_7382271_-|MBL-fold-metallo-hydrolase
MRADVRQVAEDTYLVHGHHTNWVILKDGDAVTLVDTGYPGDRQGLLESLAQVGSSPEAVAAVLITHAHNDRLGSAEHLRTTHGTPVYLHPAEVPHARRDFLQQATIADVVRNAWRPGVLPWAAHVVRVGGTEQHPVTAPEPFPAEGPLDLPGRPVPVHTPGHTDGHCVYHLPGAGIVISGDALVSGHATSRIKGPQLLPDFFHHEHARAVASLDVIAALDGDMLLPGHGPLHLGPVRAAAEQAGARASGNRRTGP
>CP033073.1|AYN42941.1|7380257_7381493_-|DUF4032-domain-containing-protein
MALQINATNPEHPALLLALPWDTPLEEWPEEYLVPLPRGISRHVVRYARAGDEVIAVKELAERPALREYELLRDLDRLGIPAVDPLAVVTGRTGCSGAPLESVLVTRHLRGSLPYRSMFETTMRPATMHRLMDALAVLLVRLHLAGFAWGDCSLSNTLFRRDAGAYAAYLVDAETGDLHPRLSPGQREYDLDLARVNISGELLDLEASGALHPSVDPVDFGHEICTRYQGLWRELTRTSVYPAGKYHYIERRIRRLNDLGFDVAEMQIEHSSTGDTVTFVPKVVDAGHHQRQLLRLTGLDAEENQARRLLNDLESWMATQDDHAPADPLAARPEVLAHRWVRDVFRPTVRAVPPELRGSMDPAEIYHELLEHRWYLSERAQHDIGLDTAVEDYIDRVLPRARATLEPTDPE
>CP033073.1|AYN42940.1|7379381_7380248_+|universal-stress-protein
MTRPITAGVDGTEESLAALDWAAREAVRRGLPLRVVHAWRYAETLAAADRDTQHGWVSRGVSQAVRAAAGRHPDLTVSVDVVEDGAAQALAGAAADAEMLVLGSRGHGPVVGFLLGSVGQQVIAEAARPVVLVRAEAETTAEAAGRDVVVGQDGAPEDSAAALRFAFETAAARGATVRAVRAWTLPPVFAYSPGSLRLLDDAGGLEPYERQSLAEALQPWRERFPEVPVAEHVEMGSAGHVLLSLTGRAQLVVVGRRAHRTAVGARIGSVAHGVLHHADCPVAVVPHA
>CP033073.1|AYN42939.1|7377484_7379161_-|response-regulator
MAQAADAARTVILTVDDDPGVSRAVARDLRRRYGASYRIVRAESGESALEALRELKLRGDLVAVILADYRMPQMNGIEFLEQALDVYPGARRVLLTAYADTDAAIDAINVVDLDHYLLKPWDPPEEKLYPVLDDLLEAWRTRAYRPVPSTKIVGHRWSARSSDVREFLARNQVPYRWYSVEEPEGRRLLAAAGQDGQRLPLVITPDGSALVEPEAPELAARVGLATTPTSEFYDLVVIGGGPAGLGAAVYGASEGLRTVLVERSATGGQAGQSSRIENYLGFPDGVSGAQLTDRARRQAARFGAEILTAREVTGLEACGAARVVRFADGSAIAAHSVILATGVQYRQLDAAGCTDLTGCGVFYGSALTEAASCQGQDVYIVGGANSAGQAAMYLSRGAKSVTLLVRGPDLSASMSYYLIQQIGEAPNISVRCHTVVEEAHGSGRLERLTLRHMVTGETEQVDAQWMFVFIGAAPLTDWLGEAVLRDGRGFILSGPDLTADGRPPAGWELDRPPYHLETSVPGVFVAGDARAESAKRVASAVGEGAMAVMLVHRYLEQS
>CP033073.1|AYN42938.1|7376036_7377488_-|histidine-kinase
MSGQVMPCSPGEIGSLFLFEKLSGQQLGRLCGAGRVELFQAGPVYTEGDPATCFFVMVEGTVVLSRRVGGDDVEVTRTSQPGVYAGAMQAYLGDRVPQVYNNSMRVTEPTRFFVLPADLFAEVMREWFPMAVHLLEGLFFGSKNTQAMIGQRERLLALGSLSAGLTHELNNPAAAAVRATSALRERVAKMRHKLGVIAGGPFSRDVLASLIEIQERTAERVAKAPVLGPLEASDREDRLTDWLADHGFEQGWQVAPTFVQAGLDVDWLEQVAAAVDEEILPNAVGWLNYTIETELLMSEIEDSTTRVSHLVDAAKQYAQLDRAPYREVDVHELLDSTLLMLSGKIGPGIGVVKEYDRTLPPVPAYPAELNQVWTNLIDNAVSAVRSAGGEGTLTVRTALDHERLLVEFRDTGPGVPTEIRDRIFDPFFTTKPVGEGTGLGLDISWRIVVNKHHGTLRVESEPGDTRFQVLLPLTAETHDEEQE
>CP033073.1|AYN42937.1|7375689_7376040_-|hypothetical-protein
MNDVEGIDPRVPPSGTGCVECEEAGGWWFHLRRCARCGHIGCCDDSPGRHATAHYRETGHPVIRSFEPGEAWFWNFATEELYGSGPELAPPAGHPADQPAPGPAGRVPADWAQTLR
>CP033073.1|AYN42947.1|7386099_7387509_+|M1-family-peptidase
MTPPRRQPARRRTAALATVPVAVAALIGAAGPAAPGTTGASGAGDPYFPLSGNGGYHVRHYDLTLRYDTTSRRLDATAVLTARATQRLTRFDLDLKGLKVTSVTVDRATAAFRRDGQELVVTPRHALRPGREFRVAVAYHGTPEPVTDPDGSADGWIPTDDGAFVAGEPQGAMTWFPADNHPKDKSSYDFTITVPEGRTAVANGVLLGRRTAHGRTTFRWRETRPMAAYLATATIGKFQIERYTTRDGIQVYNAVDAREARAAAPVLRELPSVLEWESTLFGPYPFRAAGSIVDHAPDVGYALETQTRPVYDSAPDLATLVHENAHQWFGDSVSLTAWQDIWLNEGFATYAEWLYTEQHGGRSAQQAFDALYARPASDGLWAYPPGDPGSGARIFGTPVYARGAMALHELRRAVGDKDFRRVLRAWTTGHRGGHGTTAQFVRLAEQTSGKQLKQLFHTWLYEPGKPDSA
>CP033073.1|AYN42948.1|7387550_7388285_+|hypothetical-protein
MIRRRSALAALASPLLLTGCGGGAEATERRTPSRRPAPAPAHPTSTQPAPRSIPGLGSGRSAEIPARCRQAVVVSGRGSDSPHCTVVLHQRTPDGWQSGPAWPAHNALHGWSAHHMSGDLRSPLGVYTLSDAGGRLPDPGSGLPYHRSGGFRSPGTGFRGEPLEGSFDYVIAIDYNRRPGTTPLDWTRPLGPERGGGVWLHVDHGGPTHGCVSVAKAHMKTLLRTLETHRHPVVVMGHADWLAR
>CP033073.1|AYN42949.1|7388305_7389010_+|DNA-binding-response-regulator
MCAHVLVAEDDEKQAELIRRSLLAEGHTATVVHDGAAALDAARRLRPDLLVLDLMLPVVDGFGVCRALRGGAGPDIPVVMLTARSAEDDVLLGLDLGADDYMTKPYSPRELMARIRTVLRRSGRGDGARGEDPVVRAAGISVDPVRHEVRCDGALVECTPAEFQILLAMAGEPERVFTRRQLLHCTRGFDRASTERAVDVHIMNLRRKTEADPRRPARLLTVFGVGYKLTGART
>CP033073.1|AYN42950.1|7389035_7390883_+|HAMP-domain-containing-protein
MTRRIPLRKRLLVRLLFGSALIAVCSVAATAWLAVTTTTSALKEEQGQDLAADNRILARLSGYAATHPDWAGVRHTVHELAARTGRRIALTTADRTLVADSAPRGTPLPPRPAATVDPLRTDTYTESGAQLSGIDPRVVGPYRLPAAERTKLDALAAVRERCYERYGRRAAVTRTASGRPVVTAGDGTDPAGYDASVCEDGRLNTPTPTEQRALDRLSDLARPCLRQAAPELGGRPFPTFDPGGKDPFGTRYLLAEYAAQGKGAAARTAQRCVLAARRTQLEPYAAPAAELFLGIGDQNPARFDMSPANKAKVVGVAGLVLAVTVAVTAVVAVRLVRPLRALTLAAQQPPELHVRVPVTTRDETGILAEAFNGLTERRERLEAQRRAMVSDIAHELRSPLTNIRGWLEVVRDGVVDPDPGLLDSLHEEALVLQRIIDDLQDLAAADAGTLRLHREPLRAGDLLDQVAAAHRVAAGAAGVGLRAGTGTDTDGTAWLDADPVRMRQALGNLVSNALRHTPVGGTVTLAARRDGDDVVLTVTDTGHGIPPEDLPRVFDRFWRAEKSRSRRTGGSGLGLPIVRHLVTAHGGTAEAASEHGAGAVFTLRLPGAPPPGDAA
>CP033073.1|AYN42951.1|7391477_7391729_-|WhiB-family-transcriptional-regulator
MDNWRDHAACRQEDPDLFFPIGTTGPAQVQAQQAKAVCGHCPVREQCLGWALDTDQSVGIWGGTTELERRALRRRARSRPRSG
>CP033073.1|AYN42952.1|7392217_7393105_-|LysR-family-transcriptional-regulator-ArgP
MMSELPLEQVRTLLAVVDEGTFDAAAAALHVTPSAVSQRVKALEQRTGRVLLQRTKPVRPTESGAVLVRFARQLARLERDAWGELGLNGTGEPTRVSVAVNADSLATWFLPALSRVAGLCYELHREDEDHTAALLREGLVMAAVTSSPDPVPGCTVRPLGRMRYLPVAAPGFAATHLAGRPLTEALPRVPVVVFDRKDDFQDGFVRRLGRGSAGPHRHLVPTSEGFLDAVAAGLGWGMIPEAQAGPLLEQGRLAVLAPGEWMDLALYWQQWKLDSPALAALADAVTATAAEALRH
>CP033073.1|AYN42953.1|7393171_7393786_+|amino-acid-transporter
MNHALTAAAAGFGTGLSLIVAIGAQNAFVLRQGVRRDAVLTVVGICALSDALLIALGVGGVGAVVVAWPGALRAVGIVGGAFLLCYGALAARRVLRAGTGLRAEGEAAGSRRRAVLTCLAMTWLNPHVYLDTVFLLGSLAADRGPLRWTFGLGAALASVCWFASLGFGARLLGRFLARPGAWRVLDGLVAVTMLVLGVTLIAGS
>CP033073.1|AYN42954.1|7393871_7395170_+|MFS-transporter
MDTSESSTGTDREAPAAPAPPRRGWRRWAMDTRPLRIPAYRRLWSSTIVTAVGSQLTAVAVPKQIYDITHSSAWVGYASLAGLVPMVAFALWGGAVADTVDRRKLLLVTNTGIAVTSLLFWAQAVTGLDSVVVLMVLLALQQAFFGLNSPARSASIARLVPIEQLPAANALGSTVMQTGLVAGPLLAGALIPVIGLPALYLVDALALCVTVRAVFRLPGLPPLGGPAARRAGVREIAAGFRYIARHKVLLLSFLADIVAMVLGMPRALFPELAAQTYGSYGSGLALGVLFAGIPVGAVLGGLFSGVFSRARRHGWMVIGAVVGWGVAIAGFGLSGNLWVAMAFLAVAGVADMVSTVFRGAILLSAATDEMRGRMQGVFTVVVAGGPRLADVLHGTAGSAFGPRAAVAGGGALVVVAMLALTAAVPALRRYRV
>CP033073.1|AYN42955.1|7395220_7395676_-|hypothetical-protein
MTKAIKLLTALPQAQRERLMELAEEVSFPEDRRIFEAGGTADRFWVVRSGAVHLDQQVTSRQRVTVATLGAGDMLGWSWLFPPYEWDFGAVAFSNVRAYEFDGPSVLALCVEDPLLGLSLVRTVAEILAHRLETTRGKLMDQYAIRRRGPL
>CP033073.1|AYN44013.1|7395949_7396192_-|hypothetical-protein
MTDVVDADELLRRIRRGRDCAADEERAWRERAQGLTATDPEGAREAAVRAETYAAVLRVLDEIVSPGAAAARADEVKRVT

Crispr_ID: CP033073_20

• CRISPR_ID: CP033073_20
• CRISPR_location: 8053487-8053820
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 5 spacers

Consensus repeat of CP033073_20

Consensus_repeat	Method
GTCCTCCCCGCCGACGCGGGGGTGCTTCG	PILER-CR
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CRISPRCasFinder
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CRT

spacers of CP033073_20

>20.1|8053516|32|CP033073|PILER-CR,CRISPRCasFinder,CRT
CCGAGGTGGCGGGCGCGTAGAGGCGGCAGCGG
>20.2|8053577|32|CP033073|PILER-CR,CRISPRCasFinder,CRT
CCGAGGTGGCGGGCGCGTAGAGGCGGCAGCGG
>20.3|8053638|32|CP033073|PILER-CR,CRISPRCasFinder,CRT
GAGCACACGGCCAACCTCGCCTACGATCCCGT
>20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT
CCGAACGAGCTGCTCACCGACTCCCTCATCAG
>20.5|8053760|32|CP033073|PILER-CR,CRISPRCasFinder,CRT
AAAATAGGGTGGTTGCTAAAACTCCGCCACCC

CRISPR arrays and Neighbor proteins around CP033073_20

CRISPR arrays

The CRISPR arrays of CP033073_20

>merge|CP033073|20|8053487-8053820|PILER-CR,CRISPRCasFinder,CRT
CGAAGCACCCCCGCGTCGGCGGGGAGGACCCGAGGTGGCGGGCGCGTAGAGGCGGCAGCGGCGAAGCACCCCCGCGTCGGCGGGGAGGACCCGAGGTGGCGGGCGCGTAGAGGCGGCAGCGGCGAAGCACCCCCGCGTCGGCGGGGAGGACGAGCACACGGCCAACCTCGCCTACGATCCCGTCGAAGCACCCCCGCGTCGGCGGGGAGGACCCGAACGAGCTGCTCACCGACTCCCTCATCAGCGAAGCACCCCCGCGTCGGCGGGGAGGACAAAATAGGGTGGTTGCTAAAACTCCGCCACCCCGAAGCACCCCCGCGTCGGCGGGGAGGAC

>CP033073|20|3|8053487-8053820|PILER-CR
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CCGAGGTGGCGGGCGCGTAGAGGCGGCAGCGG
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CCGAGGTGGCGGGCGCGTAGAGGCGGCAGCGG
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	GAGCACACGGCCAACCTCGCCTACGATCCCGT
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CCGAACGAGCTGCTCACCGACTCCCTCATCAG
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	AAAATAGGGTGGTTGCTAAAACTCCGCCACCC
CGAAGCACCCCCGCGTCGGCGGGGAGGAC

>CP033073|20|20|8053487-8053820|CRISPRCasFinder
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CCGAGGTGGCGGGCGCGTAGAGGCGGCAGCGG
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CCGAGGTGGCGGGCGCGTAGAGGCGGCAGCGG
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	GAGCACACGGCCAACCTCGCCTACGATCCCGT
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CCGAACGAGCTGCTCACCGACTCCCTCATCAG
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	AAAATAGGGTGGTTGCTAAAACTCCGCCACCC
CGAAGCACCCCCGCGTCGGCGGGGAGGAC

>CP033073|20|3|8053487-8053820|CRT
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CCGAGGTGGCGGGCGCGTAGAGGCGGCAGCGG
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CCGAGGTGGCGGGCGCGTAGAGGCGGCAGCGG
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	GAGCACACGGCCAACCTCGCCTACGATCCCGT
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	CCGAACGAGCTGCTCACCGACTCCCTCATCAG
CGAAGCACCCCCGCGTCGGCGGGGAGGAC	AAAATAGGGTGGTTGCTAAAACTCCGCCACCC
CGAAGCACCCCCGCGTCGGCGGGGAGGAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP033073.1|AYN43370.1|8064859_8065513_-|hypothetical-protein	unknown	unknown	gnl|CDD|380421
CP033073.1|AYN43364.1|8053926_8055219_-|IS256-family-transposase	unknown	unknown	gnl|CDD|307151
CP033073.1|AYN43359.1|8045181_8045568_+|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133388
CP033073.1|AYN43371.1|8065787_8066270_-|hypothetical-protein	unknown	unknown	gnl|CDD|223571
CP033073.1|AYN43357.1|8033011_8033983_+|hypothetical-protein	unknown	unknown	gnl|CDD|226755
CP033073.1|AYN43365.1|8056992_8057448_-|hypothetical-protein	unknown	unknown	gnl|CDD|224872
CP033073.1|AYN44066.1|8060989_8061535_-|ImmA/IrrE-family-metallo-endopeptidase	unknown	unknown	gnl|CDD|368753
CP033073.1|AYN43367.1|8062055_8062313_+|hypothetical-protein	unknown	unknown	gnl|CDD|373076
CP033073.1|AYN43368.1|8062287_8063457_+|ThiF-family-adenylyltransferase	unknown	unknown	gnl|CDD|235717
CP033073.1|AYN43361.1|8048315_8048831_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
CP033073.1|AYN44063.1|8035040_8037404_+|galactosylceramidase	unknown	unknown	gnl|CDD|366896
CP033073.1|AYN43356.1|8030795_8032661_-|glucosylceramidase	unknown	unknown	gnl|CDD|227807
CP033073.1|AYN43362.1|8049222_8050512_-|IS256-family-transposase	unknown	unknown	gnl|CDD|307151
CP033073.1|AYN43363.1|8050914_8051091_+|thiazolylpeptide-type-bacteriocin	unknown	unknown	unknown
CP033073.1|AYN43358.1|8037463_8039059_+|hypothetical-protein	unknown	unknown	gnl|CDD|238868
CP033073.1|AYN43369.1|8063453_8063855_+|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN43360.1|8047308_8048265_-|EamA-family-transporter	unknown	unknown	gnl|CDD|273359
CP033073.1|AYN44064.1|8051182_8051524_-|hypothetical-protein	unknown	unknown	unknown
CP033073.1|AYN43366.1|8061557_8061938_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376540
CP033073.1|AYN44065.1|8059419_8060247_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP033073.1|AYN43370.1|8064859_8065513_-|hypothetical-protein	gnl|CDD|380421	cd20287, cupin_pirin-like_N, pirin-like, N-terminal cupin domain. This family contains the N-terminal cupin domain of pirin and pirin-like proteins, including Escherichia coli YhhW and YhaK. Pirin functions as both a transcriptional cofactor and an apoptosis-related protein in mammals and is involved in seed germination and seedling development in plants. Proteins in this family have two tandem cupin-like folds but the C-terminal cupin fold has diverged considerably and does not have a metal binding site. The exact functions of pirins are unknown but they have quercitinase activity in Escherichia coli and are thought to play important roles in transcription and apoptosis. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.	0.00372372
CP033073.1|AYN43364.1|8053926_8055219_-|IS256-family-transposase	gnl|CDD|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	5.11169e-132
CP033073.1|AYN43359.1|8045181_8045568_+|MerR-family-transcriptional-regulator	gnl|CDD|133388	cd01282, HTH_MerR-like_sg3, Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily. Putative helix-turn-helix (HTH) MerR-like transcription regulators (subgroup 3). Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	8.55588e-36
CP033073.1|AYN43357.1|8033011_8033983_+|hypothetical-protein	gnl|CDD|226755	COG4305, COG4305, Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism].	3.03487e-30
CP033073.1|AYN43365.1|8056992_8057448_-|hypothetical-protein	gnl|CDD|224872	COG1961, PinR, Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair].	0.00036671
CP033073.1|AYN44066.1|8060989_8061535_-|ImmA/IrrE-family-metallo-endopeptidase	gnl|CDD|368753	pfam06114, Peptidase_M78, IrrE N-terminal-like domain. This entry includes the catalytic domain of the protein ImmA, which is a metallopeptidase containing an HEXXH zinc-binding motif from peptidase family M78. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibiotics. The transposon is integrated into the chromosome, but during conjugation excises itself and then moves to the recipient bacterium and re-integrate into its chromosome. Typically a conjugative tranposon encodes only the proteins required for this activity and the proteins that regulate it. During exponential growth, the ICEBs1 transposon of Bacillus subtilis is inactivated by the immunity repressor protein ImmR, which is encoded by the transposon and represses the genes for excision and transfer. Cleavage of ImmR relaxes repression and allows transfer of the transposon. ImmA has been shown to be essential for the cleavage of ImmR. This domain is also found in in metalloprotease IrrE, a central regulator of DNA damage repair in Deinococcaceae, HTH-type transcriptional regulators RamB and PrpC.	4.73687e-12
CP033073.1|AYN43367.1|8062055_8062313_+|hypothetical-protein	gnl|CDD|373076	pfam14452, Multi_ubiq, Multiubiquitin. A ubiquitin superfamily domain that is often present in multiple tandem copies in the same polypeptide. Members of this family are associated in gene neighborhoods, or on occasions fused to, bacterial homologs of components of ubiquitin-dependent modification system such as the E1, E2 and JAB metallopeptidase enzymes and a distinct metal-binding domain. The E2/UBC fold domain appears to be inactive. The JAB domain in these operons is usually fused to the E1 domain.	4.40348e-13
CP033073.1|AYN43368.1|8062287_8063457_+|ThiF-family-adenylyltransferase	gnl|CDD|235717	PRK06153, PRK06153, hypothetical protein; Provisional.	2.4468e-156
CP033073.1|AYN43361.1|8048315_8048831_+|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	6.25099e-20
CP033073.1|AYN44063.1|8035040_8037404_+|galactosylceramidase	gnl|CDD|366896	pfam02057, Glyco_hydro_59, Glycosyl hydrolase family 59.	3.5751e-139
CP033073.1|AYN43356.1|8030795_8032661_-|glucosylceramidase	gnl|CDD|227807	COG5520, COG5520, O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane].	1.68893e-54
CP033073.1|AYN43362.1|8049222_8050512_-|IS256-family-transposase	gnl|CDD|307151	pfam00872, Transposase_mut, Transposase, Mutator family.	1.06599e-129
CP033073.1|AYN43358.1|8037463_8039059_+|hypothetical-protein	gnl|CDD|238868	cd01830, XynE_like, SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.95092e-82
CP033073.1|AYN43371.1|8065787_8066270_-|hypothetical-protein	gnl|CDD|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	0.00266454
CP033073.1|AYN43360.1|8047308_8048265_-|EamA-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	8.84361e-38
CP033073.1|AYN43366.1|8061557_8061938_-|XRE-family-transcriptional-regulator	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	1.01565e-05

Protein sequences

>CP033073.1|AYN44064.1|8051182_8051524_-|hypothetical-protein
MRRGAPNSFQVFGQVNIGQTVAVVGTILILGRLDLWLYVPAAVCLIVALHFLPLARSFAQPQYWWTGGLLMALALVTVLSLAGGMDAANARALLGFGAAGILWATALHVARRG
>CP033073.1|AYN43363.1|8050914_8051091_+|thiazolylpeptide-type-bacteriocin
MNTVSVNSADIEQVFDSFDVTELEVLEISQGVALPEMGASGGKGGTSSSSSTCSSSTC
>CP033073.1|AYN43362.1|8049222_8050512_-|IS256-family-transposase
MTSNNMTEAEPVAPSEAVPAKSVDDRLIDELVGRAQAEGLQLTGEGGLLQQLTKRLLESALEGEITDHLGYDKHDPAGKNGGNSRNGTRAKTVLTDVGPVGIAVPRDREGSFEPRIVKKRQKRLSGVDEMVISLAAKGLTTGEVQAHLAEVYGAEVSRQTISTITDKVLDGMAEWQNRPLDAVYPVIFIDAIHVKIRDGAVANRPIHVALAVTVEGRRDILGLWAGDGGEGAKHWMHILTEIKNRGVNDVLMLVRDGLKGLPDAVETVWPRTTVQTCVVHLLRNSFRYAARQDWDKIARVLKPVYTAATEEAALDRFAEFADAWGKKYPIVRLWENAWEEFTPFLRFDTEIRRIVCTTNAIESVNARIRRAVKARGHFPNEQAALKCVYMAIMSLDPTGKGQARWTMRWKTALNAFDITFDGRLSAARQ
>CP033073.1|AYN43361.1|8048315_8048831_+|MarR-family-transcriptional-regulator
MNYYEDHVARIQREWARERPDVDVSPQGVIGRLHRLASLLTEQLCLVYRRYGLSEGEFDVLAALRRAGDPFERAPGELATFTMVTTGAMTKRIDRLERNGLATRRRSAEDGRGRVVALTPAGRELIDRAFADHMSNERRILDELDPDEAARLETLLTTWLARVEPPPSAPE
>CP033073.1|AYN43360.1|8047308_8048265_-|EamA-family-transporter
MRWTLVTAIAPVAWATNYFVTHEYLPTGQPLYGAAIRALPAGALLLALCRQVPHGAWWWKSLVLGTLNMGSFFALIYLAAQLLPTSIASTIMAASPTVLMLLAWAVNAERPHGLPLMGAGIGIAGVCLMLLTGNVTLNPLGVLASATAMVTSSFGYVLAKRWSTEVDILASTSWQLIAGGLVVLPLAVVREGAPPHLGVGAILGFAYVTIVATAVAFAAWFAGLRHLPAAAVGLIGLLNPVTGVLLGTVIAEETLTLRQICGLVLVLLGIALGQPIAATAAGRIRSRATGADSRRDAPTGRARRLGPGESNCATQRDG
>CP033073.1|AYN43359.1|8045181_8045568_+|MerR-family-transcriptional-regulator
MLIGELSRQTGVSERLLRYYERTELIHAERRANGYREYDDQTVETVRRVRALLAVGLPTRIIRQVLPCTQDTATLRPCPGVLTSLRDQLDILDQRAAELKTARRLLRQTIAATEDTENTAGQAPTPGT
>CP033073.1|AYN43358.1|8037463_8039059_+|hypothetical-protein
MGAVALAVVGLSLVPVHQAGAATGPQDGHVYALTAAHSGKNAQVQSASSANAVNVVQDAPSGDPTQLWQAVAHGGGSFSLVNINSGKCADVSGASTSAGAQVVQWPCTGDGNQRWTFNGSAIVSVNSGMCLDVSGSATADGAPLVQWPCNSNGNQQWSLTERPRVASFGPGMAAGGDTFSEQTLRMVVHPSAAGSGVRIRLSNLRSSTALLVGAVDAAVRSGGAAAVPGTHRTVTFGGSGSLTIAAGAELTSDVIPMSVTAGQDLLVSLYLPGRTGASTFHRDAFQTSYRSAAGSGNHTGDDAGTTFTTSMWSWYCVSGVDVVPSAVTTGTVVAFGDSITDGYNTTTDANRRWPDRLAARLQSASGGPRLAVADAGMSGNMVLRATGWDPQGPAAVDRFAHDALGQPGVRDVIFMEGINDINGTPSLTADRLINGYKNIIAQAHAAGVRIIGGTMLPNSTQTSGLAGIRVTVNNWIRTSGAFDAAVDFDAVIRDPDNPAQMLPAYDSGDHLHPNDVGMQAMANAVDLSTLR
>CP033073.1|AYN44063.1|8035040_8037404_+|galactosylceramidase
MVCALILAMMGAVLTAVPAQAATAITLDGTSAGRTYDGVGAISGGGGNSRLLIDYPEPQRSRILDYLFKPGYGAALQILKAEIGGDTNSTSGAEPSIEHTAGTVNCDRGYEWWLMKQAVARNPAIKLYGLAWGAPGWIGGGNFWSKDMTDYLLSWLGCAKSHGLAISYLGGWNERGYSTSWYESLRSALNANGYSSIKIVGSDGDWSVADDMVKDSAFAASVDIVGSHYPCGWLTPQTSCPSTANALSTGKQLWASENGSQDYNGGAAAMARANNRDYIDGRMTATINWPVIGAMTPNLPFPTAGLAVANQPWSGAYSVGQSLWVTAQTTQFTSPGWRYLDRSTGYIGGSSANGSYVTLKSTDNTDYSTVIETTQASAAQTLDFTVTGGLSTSTVHVWSTNVNSTDPATAMVHVTDITPTGGAYSLTVQPGYVYSLTTTTGQGKGTAVSPAKGSLALPYTDSYDGYATGSEAKYVQDQQGAYEVVGCGGGRAGQCVRQMSAQAPITWASLSHPYALFGDVGWKDYQVSSDVLLENAGFTELIGRATWQHSFGPEGLDGYYLRVGSTGSWSILRNDTDDKFVTLASGTVAALGTDSWHNLRLGFYGNTITGWIDGVKVGSVNDSTYGTGQAGYGNSQGETGQFDNLSIGSTTKIVGVGSGRCLDVPGFNQTDGTLTQIWDCNAGANQQWTLTSAKELRVYGHKCLDAKGHGTADGTAVQIWSCNGGPNQQWTVNSNGSLVGVESGRCLDVIKGGTADSTGLQLWSCSGGTNQQWTRTLSEPRRGSGPR
>CP033073.1|AYN43357.1|8033011_8033983_+|hypothetical-protein
MSTARQVARERRRRRRLMLGATLTLAATGVVACLVMALLPDGKADAKPAASTSVAAGRVTAATASGSGTPSPKGKASPSPSRSRSATDAPKASATTTKAKASPAKTPRPARTGSTTAASPGRIRPGTSYRGVATAYEAGVGDGACGFGPSPDMMIAAMNTTDYESARACGAYVHVRAANGASVTVRITNECPLPCAPGQIDLSHEAFIKLGDLGLGRIPITWSLLSPGSPGALLVRYKTGSSPYWCGIQVLNHRNPVAALEVRTSGGWRQLPRTPYNYFLSADGSGCGGAIRITDIYGQRLTVGDIGIRPNVIQPTGVQFARH
>CP033073.1|AYN43356.1|8030795_8032661_-|glucosylceramidase
MNLRRTYRGVGAPALALAMTAASGLLAVSSGTADATTATVGVTLTTSDLSSALTPQPGVGLGPVSSGPVNLTVDDSRSYQSIDGFGAAFTDSSTYLLQNKLDATTRDQVMKALFSRGTGIGLSLMRVPMGSSDYTATPASNPSTYSYDDDNGVADPSLSHFSTAHDDTYVIPVIKRAQSLNPSMKLFANNWSPPAWMKTNNSMLGSSGGGNGSLNPSAYGPLAQYYVKFLRDYKAKGVDVWGITPQNEPDQAPSSYSGMVLSGAEESDFIKNNLAPALAQAGLNTVILGGDSSHPDLPFANTLLGDSATYNAVYGTAWHCYWNDLQNMTTIHNSFPGKKLYESECSTGPGIAPMNATQLALESTSNWASGALLWNLALDANGGPKMGEGCNGCTGLVTIDQSTGKVTYNDNYYQLGQFSKFVVPGATRIGSTDGGGIWSQAYRNPDGGEVAVAYNTNSSRTDFTVTWNGSGSFSYTLPAHATVTFTKNAGGAATRIASKGSGRCLDDAGNPGNGTQQIIWDCGSGNYNQYFLYSAARELQIGGKCLGAAGNGTSSGTKVITWDCNGTSSQKWTFHPDGSITNDLSGLCLDITDNATTNNSPVQLWGCSGGSNQSWTAASGG
>CP033073.1|AYN43364.1|8053926_8055219_-|IS256-family-transposase
MTSNNMTEAEPVAPSEAVPAKSVDDRLIDELVGRAQAEGLQLTGEGGLLQQLTKRLLESALEGEITDHLGYDKHDPAGKNGGNSRNGTRAKTVLTDVGPVGIAVPRDREGSFEPRIVKKRQKRLSGVDEMVISLAAKGLTTGEVQAHLAEVYGAEVSRQTISTITDKVLDGMAEWQNRPLDAVYPVIFIDAIHVKIRDGAVANRPIYVALAVTVEGRRDILGLWAGDGGEGAKHWMHILTEIKNRGVNDVLMLVRDGLKGLPDAVETVWPRTTVQTCVVHLLRNSFRYAARQDWDKIARVLKPVYTAATEEAALDRFAEFADAWGKKYPAIVRLWENAWEEFTPFLRFDTEIRRIVCTTNAIESVNARIRRAVKARGHFPNEQAALKCVYMAIMSLDPTGKGQARWTMRWKTALNAFDITFDGRLSAARQ
>CP033073.1|AYN43365.1|8056992_8057448_-|hypothetical-protein
MGKHGSRAFIADQGEILPDDPEDPMRTAMRQMMSVFAQLDRGMTVAKHRRGRRIKGKKGQYAYGAPPYGRQAHKKELTEEEMEQAGRARARARARARQLRDEEQLSFREIAAVLEAEDIRPKRGERWHPETVRRLFVNTSDRPPTLGRRTA
>CP033073.1|AYN44065.1|8059419_8060247_-|hypothetical-protein
MDHLVEVIIGREVNAQLAFQIPDSTIEEMWKFRDSGGQLDGQLSQLIDQHVGPDRRAKMDNHLDQKTKFLRQRGVLTDHERDVLDRLHEYRNAAYHRDTLEPDLIADLVLAYRVLADELLSRHKPIAWVMASSDPAPIVTPHQLRGRLAEGVDIDLTSMARRFHDHAAKRVQAVSTAVATAQQLLGSKSSGETAVAPPDDDMARMLTGLSDTAKHLASWTRQAEGLKSKTSSLTGLMVPFLNLDRALSRIEPSVKRLDMIQDWWEQRRIDDLRGK
>CP033073.1|AYN44066.1|8060989_8061535_-|ImmA/IrrE-family-metallo-endopeptidase
MREVAQEERAGLSLGPLDPLDPYALAEEHGIKVYTLEGLLRFELRDEALSHFTVQSSSSWSAALVPLGSARVIVENESHKLVRRRSNIAHELGHHLLEHSFDGVVLGEDHNRQFDPVQEKQATFMAGELLVPLIAAQRMAYRGWDNERVANTYGVSEQFAQMQMKGPRVRAERAARKYGFA
>CP033073.1|AYN43366.1|8061557_8061938_-|XRE-family-transcriptional-regulator
MSESPTVDVQALHGALDAARIEKGLSWRQLAKDLGVSASTISRMANGLKPDVTAFAAMTTWLRMPAETFYVTTRDGSVREEPELVASLVPLLRARSDLSGDDVAYLEEVISAAARRFRAERESRSH
>CP033073.1|AYN43367.1|8062055_8062313_+|hypothetical-protein
MTQDRGPKPVTIIVNTRSHTWETKEITYEQAVALAYPGQQPNEQDTYTVQYSRGRDGHGSGSLTAGHSVRVKEGMIFDVYRTSRS
>CP033073.1|AYN43368.1|8062287_8063457_+|ThiF-family-adenylyltransferase
MSTVLLARDPDLSRLLDDGYDVVLHAGHIIVRHIPYATENRTVDHGFLAYPMTVSGDHLVSGTDHRIWFGGSTPCDEHGRRLTLVNPETRVIAEGMQANFMLSAKPGPDGYPDEYTKITAYARIIAAQAQALDFTATPTPGAAWQEIVDDSPFAYRDTATSRAGIAAVNRRFRGHRIVIVGLGGSGTYILDQIAKTEVDSILLIDGDTFDNHNAFRAPGAPTLDTLRERPNKAAHFALVYSNMHRGVSACAQYLDEDNLDLLESATFVFLASDDAASKPVIIDWLEAHEVPFIDVGMGIEEIDGRLSGLLRVTTSLPGRRDTARHRIPQPAPEGDAYARNIQTADLNALNAVLAVIRWKRSIGVYADATDESHTTYSLITNEITNEDLP
>CP033073.1|AYN43369.1|8063453_8063855_+|hypothetical-protein
MTAQDTLRPVFTDTFPETMDAGVLYVSIPYRTCSHLCCCGCGHEVITPLSPAQWSITYDGQNVSLTPSIGNWALPCRSHYWIDDGRIRWSRHYSTAEVAQNRDRDRHLLSQYTEEHRPRPLTSLRRHLRSWLR
>CP033073.1|AYN43370.1|8064859_8065513_-|hypothetical-protein
MLPTGRASLRHQREVFLGAVRLSGPERLVIKSTHVAKEVGLSGDTVTESLRFFDTLGIVTGARGRYAATEEGVALAEVWPADETRARVMLHHLFEGHWATDAARTALAQGPVEAEALAQHLQLGLPGHPRRGLYVVEWLIEGLIIHPDRHGRVYATSPGQVPPASTLPQPRKSEHEPSDGYVMGMCNEELRRLPTSQYVSVLRSFKTMIEQVDAVPA
>CP033073.1|AYN43371.1|8065787_8066270_-|hypothetical-protein
MAHQSFLLNSARHLRSLVAEDEEAVRAAAKRVQEAQESLEDAQLRAEASREVLQSVESRLSKVVGSPLASQDVLFPSTTADANASTPPMPVVDLIREFLRPRGEATTGEIIEHVRQSRPSTNSSNVSPELSRLVKMGDVVRPRQGVYSLSPTAKSHEGSA

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP033073_9	9.6|3575547|32|CP033073|PILER-CR	3575547-3575578	32	NC_023284	Streptomyces sp. F2 plasmid pFRL4, complete sequence	40625-40656	3	0.906
CP033073_9	9.13|3575548|31|CP033073|CRISPRCasFinder	3575548-3575578	31	NC_023284	Streptomyces sp. F2 plasmid pFRL4, complete sequence	40625-40655	3	0.903
CP033073_11	11.1|4900406|25|CP033073|CRISPRCasFinder	4900406-4900430	25	NC_019790	Deinococcus peraridilitoris DSM 19664 plasmid pDEIPE02, complete sequence	2717-2741	3	0.88
CP033073_11	11.1|4900406|25|CP033073|CRISPRCasFinder	4900406-4900430	25	NZ_CP029209	Nitratireductor sp. OM-1 plasmid pOM-1, complete sequence	841465-841489	4	0.84
CP033073_11	11.1|4900406|25|CP033073|CRISPRCasFinder	4900406-4900430	25	NZ_CP033582	Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence	244615-244639	4	0.84
CP033073_11	11.1|4900406|25|CP033073|CRISPRCasFinder	4900406-4900430	25	MG575421	Proteus phage vB_PmiP_RS51pmB, complete genome	33111-33135	4	0.84
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NC_013856	Azospirillum sp. B510 plasmid pAB510b, complete sequence	9929-9960	5	0.844
CP033073_4	4.3|1827682|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827682-1827713	32	NZ_CP029209	Nitratireductor sp. OM-1 plasmid pOM-1, complete sequence	810827-810858	5	0.844
CP033073_9	9.3|3575364|32|CP033073|PILER-CR	3575364-3575395	32	GQ379227	Streptomyces phage phiSASD1, complete genome	16860-16891	5	0.844
CP033073_9	9.10|3575365|31|CP033073|CRISPRCasFinder	3575365-3575395	31	GQ379227	Streptomyces phage phiSASD1, complete genome	16860-16890	5	0.839
CP033073_10	10.2|3575923|31|CP033073|CRISPRCasFinder	3575923-3575953	31	MT553337	Mycobacterium phage DroogsArmy, complete genome	37943-37973	5	0.839
CP033073_10	10.2|3575923|31|CP033073|CRISPRCasFinder	3575923-3575953	31	NC_028914	Mycobacterium phage Sheen, complete genome	39234-39264	5	0.839
CP033073_10	10.2|3575923|31|CP033073|CRISPRCasFinder	3575923-3575953	31	KC661275	Mycobacterium phage HINdeR, complete genome	37605-37635	5	0.839
CP033073_10	10.2|3575923|31|CP033073|CRISPRCasFinder	3575923-3575953	31	NC_016650	Rhodococcus phage RGL3, complete genome	30816-30846	5	0.839
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1118079-1118106	5	0.821
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	695050-695077	5	0.821
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	MN693668	Marine virus AFVG_250M1112, complete genome	39301-39328	5	0.821
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	396406-396433	5	0.821
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP023064	Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence	82195-82222	5	0.821
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP013110	Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence	2127649-2127676	5	0.821
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP030127	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence	362959-362986	5	0.821
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	CP003958	Rhodococcus opacus PD630 plasmid 9, complete sequence	6297-6324	5	0.821
CP033073_7	7.10|3564483|38|CP033073|CRISPRCasFinder	3564483-3564520	38	NZ_CP023152	Mycobacterium chimaera strain FLAC0070 plasmid pFLAC0070_1, complete sequence	8523-8560	6	0.842
CP033073_9	9.6|3575547|32|CP033073|PILER-CR	3575547-3575578	32	NZ_LR134468	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 26, complete sequence	100721-100752	6	0.812
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1690609-1690640	6	0.812
CP033073_9	9.10|3575365|31|CP033073|CRISPRCasFinder	3575365-3575395	31	NC_003324	Sinorhizobium phage PBC5, complete genome	32388-32418	6	0.806
CP033073_9	9.10|3575365|31|CP033073|CRISPRCasFinder	3575365-3575395	31	AF448724	Sinorhizobium meliloti phage PBC5, complete genome	32388-32418	6	0.806
CP033073_9	9.13|3575548|31|CP033073|CRISPRCasFinder	3575548-3575578	31	NC_048169	Gordonia phage BrutonGaster, complete genome	41187-41217	6	0.806
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1690610-1690640	6	0.806
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1354919-1354949	6	0.806
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1041038-1041068	6	0.806
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	541474-541504	6	0.806
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1353958-1353988	6	0.806
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1590913-1590943	6	0.806
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP027859	Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence	386014-386041	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP030772	Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence	615802-615829	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP049731	Rhizobium leguminosarum strain A1 plasmid pRL12, complete sequence	336450-336477	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP034352	Streptomyces sp. W1SF4 plasmid p2, complete sequence	115141-115168	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NC_007505	Xanthomonas campestris pv. vesicatoria str. 85-10 plasmid pXCV19, complete sequence	17170-17197	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	937596-937623	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_KR997898	Mycobacterium avium subsp. hominissuis strain 88Br plasmid pMA100, complete sequence	107592-107619	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP010057	Hymenobacter sp. DG25B plasmid, complete sequence	119596-119623	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP017193	Xanthomonas campestris pv. vesicatoria str. 85-10 plasmid p_XCV_3, complete sequence	8829-8856	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	10846-10873	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP007129	Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence	63906-63933	6	0.786
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	MN204493	Streptomyces phage Zuko, complete genome	69524-69551	6	0.786
CP033073_19	19.1|7385931|28|CP033073|CRISPRCasFinder	7385931-7385958	28	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	327136-327163	6	0.786
CP033073_7	7.5|3564178|38|CP033073|CRISPRCasFinder	3564178-3564215	38	MK686068	Streptomyces phage RemusLoopin, complete genome	27250-27287	7	0.816
CP033073_9	9.1|3575242|32|CP033073|PILER-CR	3575242-3575273	32	NC_023722	Rhodococcus phage ReqiPine5, complete genome	57661-57692	7	0.781
CP033073_9	9.3|3575364|32|CP033073|PILER-CR	3575364-3575395	32	NC_003324	Sinorhizobium phage PBC5, complete genome	32387-32418	7	0.781
CP033073_9	9.3|3575364|32|CP033073|PILER-CR	3575364-3575395	32	AF448724	Sinorhizobium meliloti phage PBC5, complete genome	32387-32418	7	0.781
CP033073_9	9.4|3575425|32|CP033073|PILER-CR	3575425-3575456	32	NZ_CP025548	Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence	79896-79927	7	0.781
CP033073_9	9.4|3575425|32|CP033073|PILER-CR	3575425-3575456	32	NZ_CP025548	Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence	130839-130870	7	0.781
CP033073_9	9.6|3575547|32|CP033073|PILER-CR	3575547-3575578	32	NC_048169	Gordonia phage BrutonGaster, complete genome	41187-41218	7	0.781
CP033073_9	9.6|3575547|32|CP033073|PILER-CR	3575547-3575578	32	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	411548-411579	7	0.781
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	NZ_CP032322	Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence	1354918-1354949	7	0.781
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	NZ_CP022367	Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence	1041038-1041069	7	0.781
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	NZ_CP032340	Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence	541474-541505	7	0.781
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1353958-1353989	7	0.781
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	NZ_CP012915	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence	1590912-1590943	7	0.781
CP033073_9	9.8|3575243|31|CP033073|CRISPRCasFinder	3575243-3575273	31	NC_023722	Rhodococcus phage ReqiPine5, complete genome	57661-57691	7	0.774
CP033073_9	9.9|3575304|31|CP033073|CRISPRCasFinder	3575304-3575334	31	NZ_AP018921	Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence	254751-254781	7	0.774
CP033073_9	9.11|3575426|31|CP033073|CRISPRCasFinder	3575426-3575456	31	NZ_CP025548	Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence	79897-79927	7	0.774
CP033073_9	9.11|3575426|31|CP033073|CRISPRCasFinder	3575426-3575456	31	NZ_CP025548	Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence	130839-130869	7	0.774
CP033073_9	9.13|3575548|31|CP033073|CRISPRCasFinder	3575548-3575578	31	NC_010408	Clavibacter michiganensis subsp. sepedonicus plasmid pCSL1, complete sequence	24740-24770	7	0.774
CP033073_9	9.13|3575548|31|CP033073|CRISPRCasFinder	3575548-3575578	31	NZ_CP016083	Streptomyces sp. SAT1 plasmid unnamed3, complete sequence	411549-411579	7	0.774
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NZ_CP032346	Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence	1124147-1124177	7	0.774
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	178904-178934	7	0.774
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	AP021851	Deinococcus grandis ATCC 43672 plasmid: pDEGR-2 DNA, complete genome	9215-9244	7	0.767
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	AP017627	Pleomorphomonas sp. SM30 plasmid pSM30-1 DNA, complete genome	119416-119445	7	0.767
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NZ_CP043441	Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence	1870242-1870271	7	0.767
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP049244	Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence	867051-867078	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP015737	Shinella sp. HZN7 plasmid pShin-01, complete sequence	158187-158214	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NC_008383	Rhizobium leguminosarum bv. viciae 3841 plasmid pRL8, complete sequence	118320-118347	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP047055	Clavibacter michiganensis subsp. michiganensis strain VL527 plasmid pVL1, complete sequence	14221-14248	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	MH399779	Microbacterium phage Jacko, complete genome	8071-8098	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	MF614627	Sinorhizobium phage phi2LM21, complete genome	3444-3471	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP039918	Agrobacterium tumefaciens strain CFBP6626 plasmid pAtCFBP6626a, complete sequence	208437-208464	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP012899	Burkholderia sp. CCGE1001 plasmid pCCGE1001a, complete sequence	390543-390570	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP047052	Clavibacter michiganensis subsp. michiganensis strain MSF322 plasmid pMSF2, complete sequence	21156-21183	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP018231	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed3	47037-47064	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP016292	Rhizobium leguminosarum strain Vaf10 plasmid unnamed4, complete sequence	124491-124518	7	0.75
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NC_013857	Azospirillum sp. B510 plasmid pAB510c, complete sequence	641833-641860	7	0.75
CP033073_19	19.1|7385931|28|CP033073|CRISPRCasFinder	7385931-7385958	28	NC_017590	Thermus thermophilus JL-18 plasmid pTTJL1802, complete sequence	118960-118987	7	0.75
CP033073_19	19.1|7385931|28|CP033073|CRISPRCasFinder	7385931-7385958	28	NC_017273	Thermus thermophilus SG0.5JP17-16 plasmid pTHTHE1601, complete sequence	55406-55433	7	0.75
CP033073_19	19.1|7385931|28|CP033073|CRISPRCasFinder	7385931-7385958	28	NZ_LR027519	Thermus thermophilus isolate TTHNAR1 plasmid 3, complete sequence	64280-64307	7	0.75
CP033073_19	19.1|7385931|28|CP033073|CRISPRCasFinder	7385931-7385958	28	NC_017767	Thermus thermophilus HB8 plasmid pVV8, complete sequence	65064-65091	7	0.75
CP033073_20	20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053699-8053730	32	NZ_CP018784	Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence	192882-192913	7	0.781
CP033073_4	4.3|1827682|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827682-1827713	32	MF766045	Streptomyces phage Daudau, complete genome	31780-31811	8	0.75
CP033073_7	7.2|3563995|38|CP033073|CRISPRCasFinder	3563995-3564032	38	NZ_CP041653	Streptomyces sp. RLB1-9 plasmid pRLB1-9.1, complete sequence	126858-126895	8	0.789
CP033073_7	7.6|3564239|38|CP033073|CRISPRCasFinder	3564239-3564276	38	NC_015951	Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence	168701-168738	8	0.789
CP033073_9	9.2|3575303|32|CP033073|PILER-CR	3575303-3575334	32	NZ_AP018921	Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence	254751-254782	8	0.75
CP033073_9	9.5|3575486|32|CP033073|PILER-CR	3575486-3575517	32	NZ_KU254577	Pseudomonas aeruginosa strain HN39 plasmid pHN39-SIM, complete sequence	270504-270535	8	0.75
CP033073_9	9.5|3575486|32|CP033073|PILER-CR	3575486-3575517	32	CP031732	Stenotrophomonas rhizophila strain GA1 plasmid unnamed3, complete sequence	243771-243802	8	0.75
CP033073_9	9.5|3575486|32|CP033073|PILER-CR	3575486-3575517	32	NZ_AP015031	Pseudomonas putida strain KF715 plasmid pKF715B, complete sequence	9091-9122	8	0.75
CP033073_9	9.6|3575547|32|CP033073|PILER-CR	3575547-3575578	32	NC_010408	Clavibacter michiganensis subsp. sepedonicus plasmid pCSL1, complete sequence	24740-24771	8	0.75
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	NZ_CP007794	Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence	178903-178934	8	0.75
CP033073_9	9.12|3575487|31|CP033073|CRISPRCasFinder	3575487-3575517	31	NZ_CP031163	Deinococcus wulumuqiensis strain NEB 479 plasmid pDrdI, complete sequence	636144-636174	8	0.742
CP033073_9	9.12|3575487|31|CP033073|CRISPRCasFinder	3575487-3575517	31	NZ_KU254577	Pseudomonas aeruginosa strain HN39 plasmid pHN39-SIM, complete sequence	270505-270535	8	0.742
CP033073_9	9.12|3575487|31|CP033073|CRISPRCasFinder	3575487-3575517	31	CP031732	Stenotrophomonas rhizophila strain GA1 plasmid unnamed3, complete sequence	243772-243802	8	0.742
CP033073_9	9.12|3575487|31|CP033073|CRISPRCasFinder	3575487-3575517	31	NZ_AP015031	Pseudomonas putida strain KF715 plasmid pKF715B, complete sequence	9092-9122	8	0.742
CP033073_9	9.13|3575548|31|CP033073|CRISPRCasFinder	3575548-3575578	31	NZ_LR134468	Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 26, complete sequence	100721-100751	8	0.742
CP033073_9	9.13|3575548|31|CP033073|CRISPRCasFinder	3575548-3575578	31	KT997861	Uncultured Mediterranean phage uvDeep-CGR2-KM20-C133, complete genome	22109-22139	8	0.742
CP033073_9	9.13|3575548|31|CP033073|CRISPRCasFinder	3575548-3575578	31	NZ_CP023993	Streptomyces malaysiensis strain DSM 4137 plasmid unnamed, complete sequence	27619-27649	8	0.742
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NZ_CP020900	Rhizobium phaseoli Brasil 5 strain Bra5 plasmid pRphaBra5d, complete sequence	768642-768672	8	0.742
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NZ_CP013526	Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence	837127-837157	8	0.742
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NZ_CP021653	Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence	1759228-1759257	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NZ_CP012940	Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence	206544-206573	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NZ_CP012944	Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence	118440-118469	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NZ_CP012688	Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence	1759226-1759255	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NC_017575	Ralstonia solanacearum Po82 megaplasmid, complete sequence	1813724-1813753	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NZ_CP026308	Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence	1813668-1813697	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	CP047139	Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence	338613-338642	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NZ_CP051295	Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence	206269-206298	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	CP047137	Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence	318966-318995	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NC_022235	Sphingomonas sp. ERG5 plasmid pCADAB1, complete sequence	43677-43706	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NZ_CP011869	Pseudonocardia sp. HH130629-09 plasmid pLS1-1, complete sequence	222734-222763	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NC_004462	Thermus thermophilus phage IN93, complete genome	7084-7113	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	MH632120	Mycobacterium phage Thonko, complete genome	24294-24323	8	0.733
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	AB063393	Thermus thermophilus phage IN93 DNA, complete genome	7084-7113	8	0.733
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NC_019846	Sinorhizobium meliloti GR4 plasmid pRmeGR4a, complete sequence	57785-57812	8	0.714
CP033073_13	13.1|4901024|28|CP033073|CRISPRCasFinder	4901024-4901051	28	NZ_CP021826	Sinorhizobium meliloti strain KH35c plasmid accessoryA, complete sequence	133002-133029	8	0.714
CP033073_19	19.1|7385931|28|CP033073|CRISPRCasFinder	7385931-7385958	28	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	769204-769231	8	0.714
CP033073_20	20.1|8053516|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053516-8053547	32	NZ_CP024310	Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence	181156-181187	8	0.75
CP033073_20	20.1|8053516|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053516-8053547	32	NZ_CP026517	Deinococcus sp. NW-56 plasmid unnamed1, complete sequence	130981-131012	8	0.75
CP033073_20	20.2|8053577|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053577-8053608	32	NZ_CP024310	Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence	181156-181187	8	0.75
CP033073_20	20.2|8053577|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053577-8053608	32	NZ_CP026517	Deinococcus sp. NW-56 plasmid unnamed1, complete sequence	130981-131012	8	0.75
CP033073_4	4.1|1827560|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827560-1827591	32	LN997843	Streptomyces reticuli genome assembly TUE45, plasmid : II	56551-56582	9	0.719
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP049157	Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence	132268-132299	9	0.719
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP049157	Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence	768869-768900	9	0.719
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	107861-107892	9	0.719
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP049317	Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence	872177-872208	9	0.719
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP049317	Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence	1510376-1510407	9	0.719
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	107807-107838	9	0.719
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP049320	Caballeronia sp. SBC2 plasmid pSBC2-4, complete sequence	269528-269559	9	0.719
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP049321	Caballeronia sp. SBC2 plasmid pSBC2-5, complete sequence	180919-180950	9	0.719
CP033073_7	7.6|3564239|38|CP033073|CRISPRCasFinder	3564239-3564276	38	NZ_CP041605	Streptomyces sp. S1D4-14 plasmid pS1D4-14.1, complete sequence	51254-51291	9	0.763
CP033073_9	9.5|3575486|32|CP033073|PILER-CR	3575486-3575517	32	NZ_CP031163	Deinococcus wulumuqiensis strain NEB 479 plasmid pDrdI, complete sequence	636144-636175	9	0.719
CP033073_9	9.6|3575547|32|CP033073|PILER-CR	3575547-3575578	32	NZ_CP023993	Streptomyces malaysiensis strain DSM 4137 plasmid unnamed, complete sequence	27618-27649	9	0.719
CP033073_9	9.6|3575547|32|CP033073|PILER-CR	3575547-3575578	32	MN304817	Phage 68_12, complete genome	26268-26299	9	0.719
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	NZ_CP020900	Rhizobium phaseoli Brasil 5 strain Bra5 plasmid pRphaBra5d, complete sequence	768642-768673	9	0.719
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	NZ_CP013526	Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence	837126-837157	9	0.719
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	MN586020	Microbacterium phage Megan, complete genome	3808-3839	9	0.719
CP033073_9	9.8|3575243|31|CP033073|CRISPRCasFinder	3575243-3575273	31	NZ_CP003988	Streptomyces sp. 769 plasmid pSGZL, complete sequence	82390-82420	9	0.71
CP033073_9	9.9|3575304|31|CP033073|CRISPRCasFinder	3575304-3575334	31	NZ_CP035902	Burkholderia glumae strain 257sh-1 plasmid plas1, complete sequence	109599-109629	9	0.71
CP033073_9	9.12|3575487|31|CP033073|CRISPRCasFinder	3575487-3575517	31	NZ_CP020446	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed6, complete sequence	14872-14902	9	0.71
CP033073_9	9.13|3575548|31|CP033073|CRISPRCasFinder	3575548-3575578	31	NZ_CP054842	Acidovorax sp. 16-35-5 plasmid unnamed2, complete sequence	88950-88980	9	0.71
CP033073_9	9.13|3575548|31|CP033073|CRISPRCasFinder	3575548-3575578	31	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	643626-643656	9	0.71
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	NC_011366	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG202, complete sequence	229952-229982	9	0.71
CP033073_9	9.14|3575609|31|CP033073|CRISPRCasFinder	3575609-3575639	31	MN586020	Microbacterium phage Megan, complete genome	3808-3838	9	0.71
CP033073_9	9.21|3575542|40|CP033073|CRT	3575542-3575581	40	NC_023284	Streptomyces sp. F2 plasmid pFRL4, complete sequence	40622-40661	9	0.775
CP033073_10	10.3|3575984|30|CP033073|CRISPRCasFinder	3575984-3576013	30	NZ_CP016082	Streptomyces sp. SAT1 plasmid unnamed2, complete sequence	78835-78864	9	0.7
CP033073_20	20.3|8053638|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053638-8053669	32	NZ_CP022363	Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence	281010-281041	9	0.719
CP033073_20	20.3|8053638|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053638-8053669	32	LR745207	uncultured phage genome assembly, chromosome: 1	202151-202182	9	0.719
CP033073_4	4.1|1827560|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827560-1827591	32	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	5840277-5840308	10	0.688
CP033073_4	4.1|1827560|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827560-1827591	32	MN234220	Gordonia phage Lambo, complete genome	22593-22624	10	0.688
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP017422	Arthrobacter sp. ZXY-2 plasmid pZXY21, complete sequence	139361-139392	10	0.688
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP017422	Arthrobacter sp. ZXY-2 plasmid pZXY21, complete sequence	179284-179315	10	0.688
CP033073_4	4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827621-1827652	32	NZ_CP017422	Arthrobacter sp. ZXY-2 plasmid pZXY21, complete sequence	226968-226999	10	0.688
CP033073_4	4.3|1827682|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	1827682-1827713	32	NZ_CP034911	Ensifer alkalisoli strain YIC4027 plasmid unnamed, complete sequence	366216-366247	10	0.688
CP033073_7	7.6|3564239|38|CP033073|CRISPRCasFinder	3564239-3564276	38	NC_016115	Streptomyces pratensis ATCC 33331 plasmid pSFLA02, complete sequence	69831-69868	10	0.737
CP033073_7	7.6|3564239|38|CP033073|CRISPRCasFinder	3564239-3564276	38	NZ_CP011523	Streptomyces sp. CFMR 7 strain CFMR-7 plasmid unnamed, complete sequence	34821-34858	10	0.737
CP033073_9	9.1|3575242|32|CP033073|PILER-CR	3575242-3575273	32	NZ_CP003988	Streptomyces sp. 769 plasmid pSGZL, complete sequence	82390-82421	10	0.688
CP033073_9	9.2|3575303|32|CP033073|PILER-CR	3575303-3575334	32	NZ_CP035902	Burkholderia glumae strain 257sh-1 plasmid plas1, complete sequence	109599-109630	10	0.688
CP033073_9	9.5|3575486|32|CP033073|PILER-CR	3575486-3575517	32	NZ_CP020446	Paracoccus yeei strain FDAARGOS_252 plasmid unnamed6, complete sequence	14871-14902	10	0.688
CP033073_9	9.6|3575547|32|CP033073|PILER-CR	3575547-3575578	32	NZ_CP054842	Acidovorax sp. 16-35-5 plasmid unnamed2, complete sequence	88950-88981	10	0.688
CP033073_9	9.6|3575547|32|CP033073|PILER-CR	3575547-3575578	32	NC_015727	Cupriavidus necator N-1 plasmid pBB1, complete sequence	643626-643657	10	0.688
CP033073_9	9.7|3575608|32|CP033073|PILER-CR	3575608-3575639	32	NC_011366	Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG202, complete sequence	229951-229982	10	0.688
CP033073_9	9.10|3575365|31|CP033073|CRISPRCasFinder	3575365-3575395	31	NZ_KY349138	Mycolicibacterium sp. CBMA 213 plasmid pCBMA213_2, complete sequence	2388-2418	10	0.677
CP033073_9	9.10|3575365|31|CP033073|CRISPRCasFinder	3575365-3575395	31	NC_019789	Deinococcus peraridilitoris DSM 19664 plasmid pDEIPE01, complete sequence	96855-96885	10	0.677
CP033073_9	9.10|3575365|31|CP033073|CRISPRCasFinder	3575365-3575395	31	NZ_CP020332	Martelella mediterranea DSM 17316 strain MACL11 plasmid pMM259, complete sequence	85599-85629	10	0.677
CP033073_20	20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053699-8053730	32	NZ_CP022220	Bradyrhizobium guangxiense strain CCBAU 53363 plasmid p53363, complete sequence	4413-4444	10	0.688
CP033073_20	20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053699-8053730	32	NZ_CP030052	Bradyrhizobium guangdongense strain CCBAU 51649 plasmid unnamed, complete sequence	596448-596479	10	0.688
CP033073_20	20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053699-8053730	32	NZ_CP030054	Bradyrhizobium guangzhouense strain CCBAU 51670 plasmid unnamed1, complete sequence	776041-776072	10	0.688
CP033073_20	20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT	8053699-8053730	32	NC_024972	Micrococcus sp. A1 plasmid pLMA1, complete sequence	24964-24995	10	0.688
CP033073_9	9.3|3575364|32|CP033073|PILER-CR	3575364-3575395	32	NZ_KY349138	Mycolicibacterium sp. CBMA 213 plasmid pCBMA213_2, complete sequence	2387-2418	11	0.656
CP033073_9	9.3|3575364|32|CP033073|PILER-CR	3575364-3575395	32	NC_019789	Deinococcus peraridilitoris DSM 19664 plasmid pDEIPE01, complete sequence	96854-96885	11	0.656
CP033073_9	9.3|3575364|32|CP033073|PILER-CR	3575364-3575395	32	NZ_CP020332	Martelella mediterranea DSM 17316 strain MACL11 plasmid pMM259, complete sequence	85598-85629	11	0.656

1. spacer 9.6|3575547|32|CP033073|PILER-CR matches to NC_023284 (Streptomyces sp. F2 plasmid pFRL4, complete sequence) position: , mismatch: 3, identity: 0.906

tcgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
tcgtcccagcggttcagctgctcgagttcggg	Protospacer
************ *************.****.

2. spacer 9.13|3575548|31|CP033073|CRISPRCasFinder matches to NC_023284 (Streptomyces sp. F2 plasmid pFRL4, complete sequence) position: , mismatch: 3, identity: 0.903

cgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
cgtcccagcggttcagctgctcgagttcggg	Protospacer
*********** *************.****.

3. spacer 11.1|4900406|25|CP033073|CRISPRCasFinder matches to NC_019790 (Deinococcus peraridilitoris DSM 19664 plasmid pDEIPE02, complete sequence) position: , mismatch: 3, identity: 0.88

gtggcgtcaagggttccggtgacgc	CRISPR spacer
gtggcgtcaagggtgacggtgacgt	Protospacer
**************  ********.

4. spacer 11.1|4900406|25|CP033073|CRISPRCasFinder matches to NZ_CP029209 (Nitratireductor sp. OM-1 plasmid pOM-1, complete sequence) position: , mismatch: 4, identity: 0.84

gtggcgtcaagggttccggtgacgc	CRISPR spacer
gaggcgtcaaaggttccggtgaccg	Protospacer
* ********.************  

5. spacer 11.1|4900406|25|CP033073|CRISPRCasFinder matches to NZ_CP033582 (Streptomyces sp. ADI95-16 plasmid pADI95-16a, complete sequence) position: , mismatch: 4, identity: 0.84

gtggcgtcaagggttccggtgacgc	CRISPR spacer
ccggagtcaagggttccggcgacgc	Protospacer
 .** **************.*****

6. spacer 11.1|4900406|25|CP033073|CRISPRCasFinder matches to MG575421 (Proteus phage vB_PmiP_RS51pmB, complete genome) position: , mismatch: 4, identity: 0.84

gtggcgtcaagggttccggtgacgc	CRISPR spacer
ttggcgtccaggtttccggtgacgt	Protospacer
 ******* *** ***********.

7. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NC_013856 (Azospirillum sp. B510 plasmid pAB510b, complete sequence) position: , mismatch: 5, identity: 0.844

-tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
ccctggtc-gcccaggatccggggcacgaggtg	Protospacer
 . ***** ****** ****** **********

8. spacer 4.3|1827682|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP029209 (Nitratireductor sp. OM-1 plasmid pOM-1, complete sequence) position: , mismatch: 5, identity: 0.844

ccgaggtgacggatggcatcgccg-gctgagct	CRISPR spacer
ccgaggtgaccgatgtcatcgccgcgcagagg-	Protospacer
********** **** ******** ** ***  

9. spacer 9.3|3575364|32|CP033073|PILER-CR matches to GQ379227 (Streptomyces phage phiSASD1, complete genome) position: , mismatch: 5, identity: 0.844

tttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
ttcgggcccggcttccagtaccccgtgaacgg	Protospacer
**.  *************** ** ********

10. spacer 9.10|3575365|31|CP033073|CRISPRCasFinder matches to GQ379227 (Streptomyces phage phiSASD1, complete genome) position: , mismatch: 5, identity: 0.839

ttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
tcgggcccggcttccagtaccccgtgaacgg	Protospacer
*.  *************** ** ********

11. spacer 10.2|3575923|31|CP033073|CRISPRCasFinder matches to MT553337 (Mycobacterium phage DroogsArmy, complete genome) position: , mismatch: 5, identity: 0.839

acttccgaggtcgctcgtcatggttgccgtc	CRISPR spacer
acacgcgaggtcgctcgtcgtggttgccttc	Protospacer
** . **************.******** **

12. spacer 10.2|3575923|31|CP033073|CRISPRCasFinder matches to NC_028914 (Mycobacterium phage Sheen, complete genome) position: , mismatch: 5, identity: 0.839

acttccgaggtcgctcgtcatggttgccgtc	CRISPR spacer
acacacgaggtcgctcgtcgtggttgccctc	Protospacer
** . **************.******** **

13. spacer 10.2|3575923|31|CP033073|CRISPRCasFinder matches to KC661275 (Mycobacterium phage HINdeR, complete genome) position: , mismatch: 5, identity: 0.839

acttccgaggtcgctcgtcatggttgccgtc	CRISPR spacer
acacgcgaggtcgctcgtcgtggttgccttc	Protospacer
** . **************.******** **

14. spacer 10.2|3575923|31|CP033073|CRISPRCasFinder matches to NC_016650 (Rhodococcus phage RGL3, complete genome) position: , mismatch: 5, identity: 0.839

acttccgaggtcgctcgtcatggttgccgtc	CRISPR spacer
acaccctcggtcgctcgtcatggttgccctc	Protospacer
** .**  ******************** **

15. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 5, identity: 0.821

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gcgcggcagccgccggtgccttcgccga	Protospacer
  * **************** ******.

16. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 5, identity: 0.821

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gcgcggcagccgccggtgccttcgccga	Protospacer
  * **************** ******.

17. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to MN693668 (Marine virus AFVG_250M1112, complete genome) position: , mismatch: 5, identity: 0.821

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gcggggcagcagccggtgccggcgccgc	Protospacer
  ******** ********** ***** 

18. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.821

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
cggtggccgccgccgctgccgtcgccgt	Protospacer
*.* *** ******* *********** 

19. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP023064 (Sinorhizobium sp. CCBAU 05631 plasmid pSS05631b, complete sequence) position: , mismatch: 5, identity: 0.821

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
cccgagcagccgccggtgccggcgcagg	Protospacer
*  *.**************** *** **

20. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP013110 (Sinorhizobium americanum strain CFNEI 73 plasmid C, complete sequence) position: , mismatch: 5, identity: 0.821

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
cccgagcagccgccggtgccggcgcagg	Protospacer
*  *.**************** *** **

21. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP030127 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence) position: , mismatch: 5, identity: 0.821

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
ccgagcgagccgccggtgccatcgccgg	Protospacer
* *.*  *************.*******

22. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to CP003958 (Rhodococcus opacus PD630 plasmid 9, complete sequence) position: , mismatch: 5, identity: 0.821

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
ccggtgaagccgccggtgccgtcgcagc	Protospacer
* ** * ****************** * 

23. spacer 7.10|3564483|38|CP033073|CRISPRCasFinder matches to NZ_CP023152 (Mycobacterium chimaera strain FLAC0070 plasmid pFLAC0070_1, complete sequence) position: , mismatch: 6, identity: 0.842

gtctggggttcggcccgcaaccaggtcgacggcgggcg	CRISPR spacer
gtctggggatcggcccgcaaccaggttgacggctacgg	Protospacer
******** *****************.****** .  *

24. spacer 9.6|3575547|32|CP033073|PILER-CR matches to NZ_LR134468 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 26, complete sequence) position: , mismatch: 6, identity: 0.812

-tcgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
atcg-cgaagcgggtccgctgctcgagctgggt	Protospacer
 *** *  ******** ************ ** 

25. spacer 9.7|3575608|32|CP033073|PILER-CR matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.812

ttgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
tagagcacgcggtcggcgccgtgcatggcgga	Protospacer
* *  *****.**************** ** *

26. spacer 9.10|3575365|31|CP033073|CRISPRCasFinder matches to NC_003324 (Sinorhizobium phage PBC5, complete genome) position: , mismatch: 6, identity: 0.806

ttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
catcgcccggcttcctgtagccggtgaactg	Protospacer
. *.*********** ******.****** *

27. spacer 9.10|3575365|31|CP033073|CRISPRCasFinder matches to AF448724 (Sinorhizobium meliloti phage PBC5, complete genome) position: , mismatch: 6, identity: 0.806

ttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
catcgcccggcttcctgtagccggtgaactg	Protospacer
. *.*********** ******.****** *

28. spacer 9.13|3575548|31|CP033073|CRISPRCasFinder matches to NC_048169 (Gordonia phage BrutonGaster, complete genome) position: , mismatch: 6, identity: 0.806

cgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
cgatcttgcgggtgagctgctcgagctcggc	Protospacer
** .*. ****** **************** 

29. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.806

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
agagcacgcggtcggcgccgtgcatggcgga	Protospacer
 *  *****.**************** ** *

30. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.806

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
tgaccacgcagtcggcgccgcgcacggcctc	Protospacer
** *****************.***.* * * 

31. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 6, identity: 0.806

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
tgaccacgcagtcggcgccgcgcacggcctc	Protospacer
** *****************.***.* * * 

32. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.806

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
tgaccacgcagtcggcgccgcgcacggcctc	Protospacer
** *****************.***.* * * 

33. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.806

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
tgaccacgcagtcggcgccgcgcacggcctc	Protospacer
** *****************.***.* * * 

34. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 6, identity: 0.806

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
tgaccacgcagtcggcgccgcgcacggcctc	Protospacer
** *****************.***.* * * 

35. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP027859 (Streptomyces clavuligerus strain ATCC 27064 plasmid pCLA1, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gggacgctgccgccggtgccgtcgccga	Protospacer
 .*. ** *******************.

36. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP030772 (Streptomyces sp. YIM 121038 plasmid pSSP121038, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
ggcggccagccgccggtgccgtcggccg	Protospacer
 . ** ****************** * *

37. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP049731 (Rhizobium leguminosarum strain A1 plasmid pRL12, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gaggggcaaccgccgatgccgtcgaacg	Protospacer
 *******.******.********   *

38. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP034352 (Streptomyces sp. W1SF4 plasmid p2, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
tcggggaagccgccgatgccgtcgcggc	Protospacer
. **** ********.********* * 

39. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NC_007505 (Xanthomonas campestris pv. vesicatoria str. 85-10 plasmid pXCV19, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gaagggcaggcgccgttgccgtcgcctt	Protospacer
 *.****** ***** **********  

40. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
acgtggccgccgccggtgccgtcaccgc	Protospacer
  * *** ***************.*** 

41. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_KR997898 (Mycobacterium avium subsp. hominissuis strain 88Br plasmid pMA100, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gcgtcgcagccgccggtgcaggcgccgg	Protospacer
  *  ************** * ******

42. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP010057 (Hymenobacter sp. DG25B plasmid, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gaggggcagccgccggtgtcgtggtcca	Protospacer
 *****************.*** *.* .

43. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP017193 (Xanthomonas campestris pv. vesicatoria str. 85-10 plasmid p_XCV_3, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gaagggcaggcgccgttgccgtcgcctt	Protospacer
 *.****** ***** **********  

44. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
cgaccgcagccgccggcgccatcgccgg	Protospacer
*..  ***********.***.*******

45. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP007129 (Gemmatirosa kalamazoonesis strain KBS708 plasmid 1, complete sequence) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
cgaccgcagccgccggcgccatcgccgg	Protospacer
*..  ***********.***.*******

46. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to MN204493 (Streptomyces phage Zuko, complete genome) position: , mismatch: 6, identity: 0.786

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
ctcagagagccgcctgtgccgtcgccgg	Protospacer
*  .*. ******* *************

47. spacer 19.1|7385931|28|CP033073|CRISPRCasFinder matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 6, identity: 0.786

agggcctcacccgggggagcggcatgct	CRISPR spacer
agggcctcgcccgggtgagcggcgaggg	Protospacer
********.****** *******. *  

48. spacer 7.5|3564178|38|CP033073|CRISPRCasFinder matches to MK686068 (Streptomyces phage RemusLoopin, complete genome) position: , mismatch: 7, identity: 0.816

acaacgttgaaccagataccggaacgctcaccc-ggatg	CRISPR spacer
gcgatgttgaaccaaattccggaacgctcacccttgat-	Protospacer
.*.*.*********.** ***************  *** 

49. spacer 9.1|3575242|32|CP033073|PILER-CR matches to NC_023722 (Rhodococcus phage ReqiPine5, complete genome) position: , mismatch: 7, identity: 0.781

gggtgggagaccggcgtccggtacgaaccgag	CRISPR spacer
gagtgggagtccggcgtcgggtacgtccccgg	Protospacer
*.******* ******** ******  ** .*

50. spacer 9.3|3575364|32|CP033073|PILER-CR matches to NC_003324 (Sinorhizobium phage PBC5, complete genome) position: , mismatch: 7, identity: 0.781

tttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
gcatcgcccggcttcctgtagccggtgaactg	Protospacer
 . *.*********** ******.****** *

51. spacer 9.3|3575364|32|CP033073|PILER-CR matches to AF448724 (Sinorhizobium meliloti phage PBC5, complete genome) position: , mismatch: 7, identity: 0.781

tttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
gcatcgcccggcttcctgtagccggtgaactg	Protospacer
 . *.*********** ******.****** *

52. spacer 9.4|3575425|32|CP033073|PILER-CR matches to NZ_CP025548 (Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.781

tggtcagcgctggactcgccgacgcg--tggccg	CRISPR spacer
tggtcagccctgaactcgccgacgtgctcagc--	Protospacer
******** ***.***********.*  ..**  

53. spacer 9.4|3575425|32|CP033073|PILER-CR matches to NZ_CP025548 (Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.781

tggtcagcgctggactcgccgacgcg--tggccg	CRISPR spacer
tggtcagccctgaactcgccgacgtgctcagc--	Protospacer
******** ***.***********.*  ..**  

54. spacer 9.6|3575547|32|CP033073|PILER-CR matches to NC_048169 (Gordonia phage BrutonGaster, complete genome) position: , mismatch: 7, identity: 0.781

tcgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
gcgatcttgcgggtgagctgctcgagctcggc	Protospacer
 ** .*. ****** **************** 

55. spacer 9.6|3575547|32|CP033073|PILER-CR matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.781

tcgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
tccgcccagcgggtcagctcctcgcgcgccgg	Protospacer
**  *************** **** ** * *.

56. spacer 9.7|3575608|32|CP033073|PILER-CR matches to NZ_CP032322 (Azospirillum brasilense strain MTCC4035 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.781

ttgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
gtgaccacgcagtcggcgccgcgcacggcctc	Protospacer
 ** *****************.***.* * * 

57. spacer 9.7|3575608|32|CP033073|PILER-CR matches to NZ_CP022367 (Azospirillum sp. TSH58 plasmid TSH58_p02, complete sequence) position: , mismatch: 7, identity: 0.781

ttgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
gtgaccacgcagtcggcgccgcgcacggcctc	Protospacer
 ** *****************.***.* * * 

58. spacer 9.7|3575608|32|CP033073|PILER-CR matches to NZ_CP032340 (Azospirillum brasilense strain MTCC4038 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.781

ttgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
gtgaccacgcagtcggcgccgcgcacggcctc	Protospacer
 ** *****************.***.* * * 

59. spacer 9.7|3575608|32|CP033073|PILER-CR matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.781

ttgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
gtgaccacgcagtcggcgccgcgcacggcctc	Protospacer
 ** *****************.***.* * * 

60. spacer 9.7|3575608|32|CP033073|PILER-CR matches to NZ_CP012915 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p1, complete sequence) position: , mismatch: 7, identity: 0.781

ttgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
gtgaccacgcagtcggcgccgcgcacggcctc	Protospacer
 ** *****************.***.* * * 

61. spacer 9.8|3575243|31|CP033073|CRISPRCasFinder matches to NC_023722 (Rhodococcus phage ReqiPine5, complete genome) position: , mismatch: 7, identity: 0.774

ggtgggagaccggcgtccggtacgaaccgag	CRISPR spacer
agtgggagtccggcgtcgggtacgtccccgg	Protospacer
.******* ******** ******  ** .*

62. spacer 9.9|3575304|31|CP033073|CRISPRCasFinder matches to NZ_AP018921 (Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence) position: , mismatch: 7, identity: 0.774

acat-caccgagcccggcgcgttctccatcct	CRISPR spacer
-cgtgcgccgagccggtcgcgttctccatcgg	Protospacer
 *.* *.******* * *************  

63. spacer 9.11|3575426|31|CP033073|CRISPRCasFinder matches to NZ_CP025548 (Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.774

ggtcagcgctggactcgccgacgcg--tggccg	CRISPR spacer
ggtcagccctgaactcgccgacgtgctcagc--	Protospacer
******* ***.***********.*  ..**  

64. spacer 9.11|3575426|31|CP033073|CRISPRCasFinder matches to NZ_CP025548 (Mycobacterium paragordonae strain 49061 plasmid unnamed2, complete sequence) position: , mismatch: 7, identity: 0.774

ggtcagcgctggactcgccgacgcg--tggccg	CRISPR spacer
ggtcagccctgaactcgccgacgtgctcagc--	Protospacer
******* ***.***********.*  ..**  

65. spacer 9.13|3575548|31|CP033073|CRISPRCasFinder matches to NC_010408 (Clavibacter michiganensis subsp. sepedonicus plasmid pCSL1, complete sequence) position: , mismatch: 7, identity: 0.774

cgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
aaccactgcggatcagctgctcgagctggga	Protospacer
 ..* * ****.*************** ***

66. spacer 9.13|3575548|31|CP033073|CRISPRCasFinder matches to NZ_CP016083 (Streptomyces sp. SAT1 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.774

cgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
ccgcccagcgggtcagctcctcgcgcgccgg	Protospacer
*  *************** **** ** * *.

67. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NZ_CP032346 (Azospirillum brasilense strain MTCC4039 plasmid p1, complete sequence) position: , mismatch: 7, identity: 0.774

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
agagcacgcggtcggcgccgtgcatggctga	Protospacer
 *  *****.**************** *  *

68. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 7, identity: 0.774

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
tgaccacgcagtcggcgccgcgcaccgcctc	Protospacer
** *****************.***.  * * 

69. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to AP021851 (Deinococcus grandis ATCC 43672 plasmid: pDEGR-2 DNA, complete genome) position: , mismatch: 7, identity: 0.767

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gatcccggcgagcttcacggtggtctgcgt	Protospacer
  . ******.***.************** 

70. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to AP017627 (Pleomorphomonas sp. SM30 plasmid pSM30-1 DNA, complete genome) position: , mismatch: 7, identity: 0.767

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
ttcgccggcgggctctacggtggcggggag	Protospacer
*.*************.*******.  * .*

71. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NZ_CP043441 (Cupriavidus campinensis strain MJ1 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gcggccggcgggcaccacggtggtggccag	Protospacer
 * ********** **********   *.*

72. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP049244 (Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gcagggcagccgccggtgccgtcaggcg	Protospacer
  .********************.   *

73. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP015737 (Shinella sp. HZN7 plasmid pShin-01, complete sequence) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gtaccgccgccgccggtgccgtcgccgc	Protospacer
  .  ** ******************* 

74. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NC_008383 (Rhizobium leguminosarum bv. viciae 3841 plasmid pRL8, complete sequence) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
ggatggcagccgaaggtgccgtcgccgc	Protospacer
 .. ********  ************* 

75. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP047055 (Clavibacter michiganensis subsp. michiganensis strain VL527 plasmid pVL1, complete sequence) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gctcggccgccgccggtgccggcgccgt	Protospacer
    *** ************* ***** 

76. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to MH399779 (Microbacterium phage Jacko, complete genome) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
ttggggcagccgcccgtgacgtcgcgat	Protospacer
. ************ *** ****** . 

77. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to MF614627 (Sinorhizobium phage phi2LM21, complete genome) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
aaaatccagccgccgttgccgtcgccgt	Protospacer
 *..  ********* *********** 

78. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP039918 (Agrobacterium tumefaciens strain CFBP6626 plasmid pAtCFBP6626a, complete sequence) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gcacggcagccgcccatgccgtcgccga	Protospacer
  . ********** .***********.

79. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP012899 (Burkholderia sp. CCGE1001 plasmid pCCGE1001a, complete sequence) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gccccgcagccgccggagccgccgccgg	Protospacer
     *********** ****.******

80. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP047052 (Clavibacter michiganensis subsp. michiganensis strain MSF322 plasmid pMSF2, complete sequence) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
gctcggccgccgccggtgccggcgccgt	Protospacer
    *** ************* ***** 

81. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP018231 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed3) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
ggatggcagccgaaggtgccgtcgccgc	Protospacer
 .. ********  ************* 

82. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP016292 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed4, complete sequence) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
ggatggcagccgaaggtgccgtcgccgc	Protospacer
 .. ********  ************* 

83. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NC_013857 (Azospirillum sp. B510 plasmid pAB510c, complete sequence) position: , mismatch: 7, identity: 0.75

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
agcacgcagccggcggtgccgccgccgg	Protospacer
 . . ******* ********.******

84. spacer 19.1|7385931|28|CP033073|CRISPRCasFinder matches to NC_017590 (Thermus thermophilus JL-18 plasmid pTTJL1802, complete sequence) position: , mismatch: 7, identity: 0.75

agggcctcacccgggggagcggcatgct	CRISPR spacer
gctacctcacccgggggtgcggcacgcc	Protospacer
.  .************* ******.**.

85. spacer 19.1|7385931|28|CP033073|CRISPRCasFinder matches to NC_017273 (Thermus thermophilus SG0.5JP17-16 plasmid pTHTHE1601, complete sequence) position: , mismatch: 7, identity: 0.75

agggcctcacccgggggagcggcatgct	CRISPR spacer
gctacctcacccgggggtgcggcacgcc	Protospacer
.  .************* ******.**.

86. spacer 19.1|7385931|28|CP033073|CRISPRCasFinder matches to NZ_LR027519 (Thermus thermophilus isolate TTHNAR1 plasmid 3, complete sequence) position: , mismatch: 7, identity: 0.75

agggcctcacccgggggagcggcatgct	CRISPR spacer
gctacctcacccgggggtgcggcacgcc	Protospacer
.  .************* ******.**.

87. spacer 19.1|7385931|28|CP033073|CRISPRCasFinder matches to NC_017767 (Thermus thermophilus HB8 plasmid pVV8, complete sequence) position: , mismatch: 7, identity: 0.75

agggcctcacccgggggagcggcatgct	CRISPR spacer
gctacctcacccgggggtgcggcacgcc	Protospacer
.  .************* ******.**.

88. spacer 20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP018784 (Curtobacterium pusillum strain AA3 plasmid pCPAA3, complete sequence) position: , mismatch: 7, identity: 0.781

ccgaacgagctgctcaccgactccctcatcag	CRISPR spacer
accatcgacctgctcaccgaatccctcaccgg	Protospacer
 * * *** *********** *******.*.*

89. spacer 4.3|1827682|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to MF766045 (Streptomyces phage Daudau, complete genome) position: , mismatch: 8, identity: 0.75

ccgaggtgacggatggcatcgccggctgagct	CRISPR spacer
ccgaggagacggacggcatcgcccagcgggca	Protospacer
****** ******.********* . .*.** 

90. spacer 7.2|3563995|38|CP033073|CRISPRCasFinder matches to NZ_CP041653 (Streptomyces sp. RLB1-9 plasmid pRLB1-9.1, complete sequence) position: , mismatch: 8, identity: 0.789

ccgtggatcccgaccatggacgacctcgccgatgggtg	CRISPR spacer
ccgtggattcccaccatggacgacctcgccgacttcga	Protospacer
********.** ********************.    .

91. spacer 7.6|3564239|38|CP033073|CRISPRCasFinder matches to NC_015951 (Streptomyces violaceusniger Tu 4113 plasmid pSTRVI01, complete sequence) position: , mismatch: 8, identity: 0.789

agcgtcctcgatttcgaccgcgcgcctctcggagagtg	CRISPR spacer
ggcgtcctcggtttcgaccgcgcgccgctcggtttcgg	Protospacer
.*********.*************** *****     *

92. spacer 9.2|3575303|32|CP033073|PILER-CR matches to NZ_AP018921 (Pseudonocardia autotrophica strain NBRC 12743 plasmid pPA12743CP, complete sequence) position: , mismatch: 8, identity: 0.75

gacat-caccgagcccggcgcgttctccatcct	CRISPR spacer
-ccgtgcgccgagccggtcgcgttctccatcgg	Protospacer
  *.* *.******* * *************  

93. spacer 9.5|3575486|32|CP033073|PILER-CR matches to NZ_KU254577 (Pseudomonas aeruginosa strain HN39 plasmid pHN39-SIM, complete sequence) position: , mismatch: 8, identity: 0.75

tcctcccggctgctgctcgtgcgctcggggga	CRISPR spacer
tctcgtgggctgctgctcttgcgcccggggaa	Protospacer
**.. . *********** *****.*****.*

94. spacer 9.5|3575486|32|CP033073|PILER-CR matches to CP031732 (Stenotrophomonas rhizophila strain GA1 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.75

tcctcccggctgctgctcgtgcgctcggggga	CRISPR spacer
tctcgtgggctgctgctcttgcgcccggggaa	Protospacer
**.. . *********** *****.*****.*

95. spacer 9.5|3575486|32|CP033073|PILER-CR matches to NZ_AP015031 (Pseudomonas putida strain KF715 plasmid pKF715B, complete sequence) position: , mismatch: 8, identity: 0.75

tcctcccggctgctgctcgtgcgctcggggga	CRISPR spacer
tctcgtgggctgctgctcttgcgcccggggaa	Protospacer
**.. . *********** *****.*****.*

96. spacer 9.6|3575547|32|CP033073|PILER-CR matches to NC_010408 (Clavibacter michiganensis subsp. sepedonicus plasmid pCSL1, complete sequence) position: , mismatch: 8, identity: 0.75

tcgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
caaccactgcggatcagctgctcgagctggga	Protospacer
. ..* * ****.*************** ***

97. spacer 9.7|3575608|32|CP033073|PILER-CR matches to NZ_CP007794 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p1, complete sequence) position: , mismatch: 8, identity: 0.75

ttgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
gtgaccacgcagtcggcgccgcgcaccgcctc	Protospacer
 ** *****************.***.  * * 

98. spacer 9.12|3575487|31|CP033073|CRISPRCasFinder matches to NZ_CP031163 (Deinococcus wulumuqiensis strain NEB 479 plasmid pDrdI, complete sequence) position: , mismatch: 8, identity: 0.742

cctcccggctgctgctcgtgcgctcggggga	CRISPR spacer
ccgccccgctgctgctcgtgcgccagcagcg	Protospacer
** *** ****************. * .* .

99. spacer 9.12|3575487|31|CP033073|CRISPRCasFinder matches to NZ_KU254577 (Pseudomonas aeruginosa strain HN39 plasmid pHN39-SIM, complete sequence) position: , mismatch: 8, identity: 0.742

cctcccggctgctgctcgtgcgctcggggga	CRISPR spacer
ctcgtgggctgctgctcttgcgcccggggaa	Protospacer
*.. . *********** *****.*****.*

100. spacer 9.12|3575487|31|CP033073|CRISPRCasFinder matches to CP031732 (Stenotrophomonas rhizophila strain GA1 plasmid unnamed3, complete sequence) position: , mismatch: 8, identity: 0.742

cctcccggctgctgctcgtgcgctcggggga	CRISPR spacer
ctcgtgggctgctgctcttgcgcccggggaa	Protospacer
*.. . *********** *****.*****.*

101. spacer 9.12|3575487|31|CP033073|CRISPRCasFinder matches to NZ_AP015031 (Pseudomonas putida strain KF715 plasmid pKF715B, complete sequence) position: , mismatch: 8, identity: 0.742

cctcccggctgctgctcgtgcgctcggggga	CRISPR spacer
ctcgtgggctgctgctcttgcgcccggggaa	Protospacer
*.. . *********** *****.*****.*

102. spacer 9.13|3575548|31|CP033073|CRISPRCasFinder matches to NZ_LR134468 (Tsukamurella tyrosinosolvens strain NCTC13231 plasmid 26, complete sequence) position: , mismatch: 8, identity: 0.742

cgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
tcgcgaagcgggtccgctgctcgagctgggt	Protospacer
.  *  ******** ************ ** 

103. spacer 9.13|3575548|31|CP033073|CRISPRCasFinder matches to KT997861 (Uncultured Mediterranean phage uvDeep-CGR2-KM20-C133, complete genome) position: , mismatch: 8, identity: 0.742

cgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
cctgagctcgggtcagctcctcgagctcggt	Protospacer
* *     ********** *********** 

104. spacer 9.13|3575548|31|CP033073|CRISPRCasFinder matches to NZ_CP023993 (Streptomyces malaysiensis strain DSM 4137 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.742

cgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
cggcccagctggtcagctgctcggcgtggtt	Protospacer
** ****** *************.  * *  

105. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NZ_CP020900 (Rhizobium phaseoli Brasil 5 strain Bra5 plasmid pRphaBra5d, complete sequence) position: , mismatch: 8, identity: 0.742

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
cgcgctcgcagccggcggcgtgcatgtcgcc	Protospacer
.*. * *****.***** ***********. 

106. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NZ_CP013526 (Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence) position: , mismatch: 8, identity: 0.742

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
cgcgctcgcagccggcggcgtgcatgtcgcc	Protospacer
.*. * *****.***** ***********. 

107. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NZ_CP021653 (Ralstonia solanacearum strain RS 488 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gccgcgcgcgggctccacggtggtgcacat	Protospacer
 ****  ***************** ..*. 

108. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NZ_CP012940 (Ralstonia solanacearum strain UW163 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gccgcgcgcgggctccacggtggtgcacat	Protospacer
 ****  ***************** ..*. 

109. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NZ_CP012944 (Ralstonia solanacearum strain IBSBF1503 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gccgcgcgcgggctccacggtggtgcacat	Protospacer
 ****  ***************** ..*. 

110. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NZ_CP012688 (Ralstonia solanacearum strain UY031 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gccgcgcgcgggctccacggtggtgcacat	Protospacer
 ****  ***************** ..*. 

111. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NC_017575 (Ralstonia solanacearum Po82 megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gccgcgcgcgggctccacggtggtgcacat	Protospacer
 ****  ***************** ..*. 

112. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NZ_CP026308 (Ralstonia solanacearum strain IBSBF 2571 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gccgcgcgcgggctccacggtggtgcacat	Protospacer
 ****  ***************** ..*. 

113. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to CP047139 (Ralstonia solanacearum strain CFBP 8695 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gccgcgcgcgggctccacggtggtgcacat	Protospacer
 ****  ***************** ..*. 

114. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NZ_CP051295 (Ralstonia solanacearum strain CIAT_078 plasmid megaplasmid, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gccgcgcgcgggctccacggtggtgcacat	Protospacer
 ****  ***************** ..*. 

115. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to CP047137 (Ralstonia solanacearum strain CFBP 8697 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gccgcgcgcgggctccacggtggtgcacat	Protospacer
 ****  ***************** ..*. 

116. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NC_022235 (Sphingomonas sp. ERG5 plasmid pCADAB1, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
accgccggcggcctccacggttgtgcagcg	Protospacer
 ********** ********* ** ..  *

117. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NZ_CP011869 (Pseudonocardia sp. HH130629-09 plasmid pLS1-1, complete sequence) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
ggtgatcgcgggctctacggtggtcagcgg	Protospacer
  .* . ********.********* ****

118. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NC_004462 (Thermus thermophilus phage IN93, complete genome) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
cacgccggcgggctccacgaaggtcacttg	Protospacer
. *****************. ****  . *

119. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to MH632120 (Mycobacterium phage Thonko, complete genome) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
ccgctcggcgggctgctcggtggtctgctc	Protospacer
.*  .********* * ***********  

120. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to AB063393 (Thermus thermophilus phage IN93 DNA, complete genome) position: , mismatch: 8, identity: 0.733

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
cacgccggcgggctccacgaaggtcacttg	Protospacer
. *****************. ****  . *

121. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NC_019846 (Sinorhizobium meliloti GR4 plasmid pRmeGR4a, complete sequence) position: , mismatch: 8, identity: 0.714

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
ttctcctagccgccgctgccgtcgccgg	Protospacer
.     .******** ************

122. spacer 13.1|4901024|28|CP033073|CRISPRCasFinder matches to NZ_CP021826 (Sinorhizobium meliloti strain KH35c plasmid accessoryA, complete sequence) position: , mismatch: 8, identity: 0.714

caggggcagccgccggtgccgtcgccgg	CRISPR spacer
ttctcctagccgccgctgccgtcgccgg	Protospacer
.     .******** ************

123. spacer 19.1|7385931|28|CP033073|CRISPRCasFinder matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 8, identity: 0.714

agggcctcacccgggggagcggcatgct	CRISPR spacer
catcgctcacccgggcgagcggcatgag	Protospacer
 .   ********** **********  

124. spacer 20.1|8053516|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024310 (Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence) position: , mismatch: 8, identity: 0.75

ccgaggtggcgggcgcgtagagg--cggcagcgg	CRISPR spacer
acgaggtggcgggcgcatagacgcccgacgcc--	Protospacer
 ***************.**** *  **.*. *  

125. spacer 20.1|8053516|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026517 (Deinococcus sp. NW-56 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

ccgaggtggcgggcgcgtagaggcggcagcgg	CRISPR spacer
cctgggtggcgggcgcgtcggggcggctccac	Protospacer
** .************** *.******  *. 

126. spacer 20.2|8053577|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024310 (Sinorhizobium fredii strain NXT3 plasmid pSfreNXT3c, complete sequence) position: , mismatch: 8, identity: 0.75

ccgaggtggcgggcgcgtagagg--cggcagcgg	CRISPR spacer
acgaggtggcgggcgcatagacgcccgacgcc--	Protospacer
 ***************.**** *  **.*. *  

127. spacer 20.2|8053577|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026517 (Deinococcus sp. NW-56 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.75

ccgaggtggcgggcgcgtagaggcggcagcgg	CRISPR spacer
cctgggtggcgggcgcgtcggggcggctccac	Protospacer
** .************** *.******  *. 

128. spacer 4.1|1827560|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to LN997843 (Streptomyces reticuli genome assembly TUE45, plasmid : II) position: , mismatch: 9, identity: 0.719

ccggcgcagtggccgcagatacgggccgatgg	CRISPR spacer
accgggcagatgccgcagatacgggccgtgat	Protospacer
 * * ****  *****************  . 

129. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049157 (Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence) position: , mismatch: 9, identity: 0.719

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
cgaggtcggcccattatctggtgcactgagcc	Protospacer
.* ********** ****.******* ..*. 

130. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049157 (Caballeronia sp. SBC1 plasmid pSBC1_1, complete sequence) position: , mismatch: 9, identity: 0.719

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
cgaggtcggcccattatctggtgcactgagcc	Protospacer
.* ********** ****.******* ..*. 

131. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 9, identity: 0.719

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
cgaggtcggcccattatctggtgcactgagcc	Protospacer
.* ********** ****.******* ..*. 

132. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049317 (Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence) position: , mismatch: 9, identity: 0.719

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
cgaggtcggcccattatctggtgcactgagcc	Protospacer
.* ********** ****.******* ..*. 

133. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049317 (Caballeronia sp. SBC2 plasmid pSBC2-1, complete sequence) position: , mismatch: 9, identity: 0.719

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
cgaggtcggcccattatctggtgcactgagcc	Protospacer
.* ********** ****.******* ..*. 

134. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 9, identity: 0.719

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
cgaggtcggcccattatctggtgcactgagcc	Protospacer
.* ********** ****.******* ..*. 

135. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049320 (Caballeronia sp. SBC2 plasmid pSBC2-4, complete sequence) position: , mismatch: 9, identity: 0.719

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
cgaggtcggcccattatctggtgcactgagcc	Protospacer
.* ********** ****.******* ..*. 

136. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049321 (Caballeronia sp. SBC2 plasmid pSBC2-5, complete sequence) position: , mismatch: 9, identity: 0.719

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
cgaggtcggcccattatctggtgcactgagcc	Protospacer
.* ********** ****.******* ..*. 

137. spacer 7.6|3564239|38|CP033073|CRISPRCasFinder matches to NZ_CP041605 (Streptomyces sp. S1D4-14 plasmid pS1D4-14.1, complete sequence) position: , mismatch: 9, identity: 0.763

agcgtcctcgatttcgaccgcgcgcctctcggagagtg	CRISPR spacer
ggcgtcctcgatttcgactgcgcgccgctcgatttcgg	Protospacer
.*****************.******* ****.     *

138. spacer 9.5|3575486|32|CP033073|PILER-CR matches to NZ_CP031163 (Deinococcus wulumuqiensis strain NEB 479 plasmid pDrdI, complete sequence) position: , mismatch: 9, identity: 0.719

tcctcccggctgctgctcgtgcgctcggggga	CRISPR spacer
cccgccccgctgctgctcgtgcgccagcagcg	Protospacer
.** *** ****************. * .* .

139. spacer 9.6|3575547|32|CP033073|PILER-CR matches to NZ_CP023993 (Streptomyces malaysiensis strain DSM 4137 plasmid unnamed, complete sequence) position: , mismatch: 9, identity: 0.719

tcgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
gcggcccagctggtcagctgctcggcgtggtt	Protospacer
 ** ****** *************.  * *  

140. spacer 9.6|3575547|32|CP033073|PILER-CR matches to MN304817 (Phage 68_12, complete genome) position: , mismatch: 9, identity: 0.719

tcgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
tcgtcccagagcgtcagctgctcacccatgct	Protospacer
********* * ***********.  * .*  

141. spacer 9.7|3575608|32|CP033073|PILER-CR matches to NZ_CP020900 (Rhizobium phaseoli Brasil 5 strain Bra5 plasmid pRphaBra5d, complete sequence) position: , mismatch: 9, identity: 0.719

ttgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
gcgcgctcgcagccggcggcgtgcatgtcgcc	Protospacer
 .*. * *****.***** ***********. 

142. spacer 9.7|3575608|32|CP033073|PILER-CR matches to NZ_CP013526 (Rhizobium phaseoli strain R744 plasmid pRphaR744d, complete sequence) position: , mismatch: 9, identity: 0.719

ttgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
gcgcgctcgcagccggcggcgtgcatgtcgcc	Protospacer
 .*. * *****.***** ***********. 

143. spacer 9.7|3575608|32|CP033073|PILER-CR matches to MN586020 (Microbacterium phage Megan, complete genome) position: , mismatch: 9, identity: 0.719

ttgtcca-----cgcagtcggcgccgtgcatgtcgta	CRISPR spacer
-----cacgggccgcagtcgccgcagtgcatgtcgcc	Protospacer
     **     ******** *** **********. 

144. spacer 9.8|3575243|31|CP033073|CRISPRCasFinder matches to NZ_CP003988 (Streptomyces sp. 769 plasmid pSGZL, complete sequence) position: , mismatch: 9, identity: 0.71

ggtgggagaccggcgtccggtacgaaccgag	CRISPR spacer
tggtagagaccggcgaccggtacgagcccta	Protospacer
 *  .********** *********.**  .

145. spacer 9.9|3575304|31|CP033073|CRISPRCasFinder matches to NZ_CP035902 (Burkholderia glumae strain 257sh-1 plasmid plas1, complete sequence) position: , mismatch: 9, identity: 0.71

acatcaccgagcccggcgcgttctccatcct	CRISPR spacer
cgggcaccgagcccggcgcgctcaccaagca	Protospacer
  . ****************.** ***  * 

146. spacer 9.12|3575487|31|CP033073|CRISPRCasFinder matches to NZ_CP020446 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed6, complete sequence) position: , mismatch: 9, identity: 0.71

cctcccggctgctgctcgtgcgctcggggga	CRISPR spacer
tcgtaaagcggctgctcgtgcgctagggggc	Protospacer
.* .  .** ************** ***** 

147. spacer 9.13|3575548|31|CP033073|CRISPRCasFinder matches to NZ_CP054842 (Acidovorax sp. 16-35-5 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.71

cgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
gaacccagcgagtccgctgctcgagccggtg	Protospacer
 . *******.*** ***********. * .

148. spacer 9.13|3575548|31|CP033073|CRISPRCasFinder matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 9, identity: 0.71

cgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
gaagctctcgggtcagcttctcgagcgcgga	Protospacer
 .  *.  ********** ******* ****

149. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to NC_011366 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG202, complete sequence) position: , mismatch: 9, identity: 0.71

tgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
gccattcgccgccggcgccgtgcatgtcgtc	Protospacer
  . . *** *.****************** 

150. spacer 9.14|3575609|31|CP033073|CRISPRCasFinder matches to MN586020 (Microbacterium phage Megan, complete genome) position: , mismatch: 9, identity: 0.71

tgtcca-----cgcagtcggcgccgtgcatgtcgta	CRISPR spacer
-----acgggccgcagtcgccgcagtgcatgtcgcc	Protospacer
     *     ******** *** **********. 

151. spacer 9.21|3575542|40|CP033073|CRT matches to NC_023284 (Streptomyces sp. F2 plasmid pFRL4, complete sequence) position: , mismatch: 9, identity: 0.775

acccgtcgtcccagcgggtcagctgctcgagctcggagtt	CRISPR spacer
tgaagtcgtcccagcggttcagctgctcgagttcggggcc	Protospacer
    ************* *************.****.*..

152. spacer 10.3|3575984|30|CP033073|CRISPRCasFinder matches to NZ_CP016082 (Streptomyces sp. SAT1 plasmid unnamed2, complete sequence) position: , mismatch: 9, identity: 0.7

tccgccggcgggctccacggtggtctgcgg	CRISPR spacer
gccgccggccggctccacggtgatgccgat	Protospacer
 ******** ************.* .  . 

153. spacer 20.3|8053638|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022363 (Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence) position: , mismatch: 9, identity: 0.719

gagcacacggccaacctcgcctacgatcccgt	CRISPR spacer
ctgggggcggcgatcctcgcctacgatcccgg	Protospacer
  * . .**** * ***************** 

154. spacer 20.3|8053638|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to LR745207 (uncultured phage genome assembly, chromosome: 1) position: , mismatch: 9, identity: 0.719

gagcacacggccaacctcgcctacgatcccgt	CRISPR spacer
atacccacggccaacgtcacctacgatctggg	Protospacer
. .* ********** **.*********. * 

155. spacer 4.1|1827560|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 10, identity: 0.688

ccggcgcagtggccgcagatacgggccgatgg	CRISPR spacer
gtcgtagagcggccgcagatacgggtcgatct	Protospacer
 . *.. **.***************.****  

156. spacer 4.1|1827560|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to MN234220 (Gordonia phage Lambo, complete genome) position: , mismatch: 10, identity: 0.688

ccggcgcagtggccgcagatacgggccgatgg	CRISPR spacer
tctcgtcaatggccgcagatacggcccgagct	Protospacer
.*    **.*************** ****   

157. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017422 (Arthrobacter sp. ZXY-2 plasmid pZXY21, complete sequence) position: , mismatch: 10, identity: 0.688

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
gcctcacagcccagtatccgatgcacgtggtc	Protospacer
  .   *.************.****** *** 

158. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017422 (Arthrobacter sp. ZXY-2 plasmid pZXY21, complete sequence) position: , mismatch: 10, identity: 0.688

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
gcctcacagcccagtatccgatgcacgtggtc	Protospacer
  .   *.************.****** *** 

159. spacer 4.2|1827621|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017422 (Arthrobacter sp. ZXY-2 plasmid pZXY21, complete sequence) position: , mismatch: 10, identity: 0.688

tgtggtcggcccagtatccggtgcacgaggtg	CRISPR spacer
gcctcacagcccagtatccgatgcacgtggtc	Protospacer
  .   *.************.****** *** 

160. spacer 4.3|1827682|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP034911 (Ensifer alkalisoli strain YIC4027 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

ccgaggtgacggatggcatcgccggctgagct	CRISPR spacer
acaaggtgacggatgtgatcgccggcctcaag	Protospacer
 *.************  *********.  .  

161. spacer 7.6|3564239|38|CP033073|CRISPRCasFinder matches to NC_016115 (Streptomyces pratensis ATCC 33331 plasmid pSFLA02, complete sequence) position: , mismatch: 10, identity: 0.737

agcgtcctcgatttcgaccgcgcgcctctcggagagtg	CRISPR spacer
ctcgtcctcgatttcgaccgcacgccgctcgatttcgg	Protospacer
  *******************.**** ****.     *

162. spacer 7.6|3564239|38|CP033073|CRISPRCasFinder matches to NZ_CP011523 (Streptomyces sp. CFMR 7 strain CFMR-7 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.737

agcgtcctcgatttcgaccgcgcgcctctcggagagtg	CRISPR spacer
ctcgtcctccatttcgaccgcgcgccgctcgatttcgg	Protospacer
  ******* **************** ****.     *

163. spacer 9.1|3575242|32|CP033073|PILER-CR matches to NZ_CP003988 (Streptomyces sp. 769 plasmid pSGZL, complete sequence) position: , mismatch: 10, identity: 0.688

gggtgggagaccggcgtccggtacgaaccgag	CRISPR spacer
ctggtagagaccggcgaccggtacgagcccta	Protospacer
  *  .********** *********.**  .

164. spacer 9.2|3575303|32|CP033073|PILER-CR matches to NZ_CP035902 (Burkholderia glumae strain 257sh-1 plasmid plas1, complete sequence) position: , mismatch: 10, identity: 0.688

gacatcaccgagcccggcgcgttctccatcct	CRISPR spacer
ccgggcaccgagcccggcgcgctcaccaagca	Protospacer
   . ****************.** ***  * 

165. spacer 9.5|3575486|32|CP033073|PILER-CR matches to NZ_CP020446 (Paracoccus yeei strain FDAARGOS_252 plasmid unnamed6, complete sequence) position: , mismatch: 10, identity: 0.688

tcctcccggctgctgctcgtgcgctcggggga	CRISPR spacer
atcgtaaagcggctgctcgtgcgctagggggc	Protospacer
 .* .  .** ************** ***** 

166. spacer 9.6|3575547|32|CP033073|PILER-CR matches to NZ_CP054842 (Acidovorax sp. 16-35-5 plasmid unnamed2, complete sequence) position: , mismatch: 10, identity: 0.688

tcgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
cgaacccagcgagtccgctgctcgagccggtg	Protospacer
. . *******.*** ***********. * .

167. spacer 9.6|3575547|32|CP033073|PILER-CR matches to NC_015727 (Cupriavidus necator N-1 plasmid pBB1, complete sequence) position: , mismatch: 10, identity: 0.688

tcgtcccagcgggtcagctgctcgagctcgga	CRISPR spacer
agaagctctcgggtcagcttctcgagcgcgga	Protospacer
  .  *.  ********** ******* ****

168. spacer 9.7|3575608|32|CP033073|PILER-CR matches to NC_011366 (Rhizobium leguminosarum bv. trifolii WSM2304 plasmid pRLG202, complete sequence) position: , mismatch: 10, identity: 0.688

ttgtccacgcagtcggcgccgtgcatgtcgta	CRISPR spacer
cgccattcgccgccggcgccgtgcatgtcgtc	Protospacer
.  . . *** *.****************** 

169. spacer 9.10|3575365|31|CP033073|CRISPRCasFinder matches to NZ_KY349138 (Mycolicibacterium sp. CBMA 213 plasmid pCBMA213_2, complete sequence) position: , mismatch: 10, identity: 0.677

ttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
gaaagcccggcttccagaagccggtgacgcc	Protospacer
    ************* ****.****    

170. spacer 9.10|3575365|31|CP033073|CRISPRCasFinder matches to NC_019789 (Deinococcus peraridilitoris DSM 19664 plasmid pDEIPE01, complete sequence) position: , mismatch: 10, identity: 0.677

ttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
ccaccgccggcttccagacgccagtgaacac	Protospacer
.. .  ***********  **********. 

171. spacer 9.10|3575365|31|CP033073|CRISPRCasFinder matches to NZ_CP020332 (Martelella mediterranea DSM 17316 strain MACL11 plasmid pMM259, complete sequence) position: , mismatch: 10, identity: 0.677

ttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
cgccatccggcttccagtagatagtgaaccc	Protospacer
. ....************** .*******  

172. spacer 20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022220 (Bradyrhizobium guangxiense strain CCBAU 53363 plasmid p53363, complete sequence) position: , mismatch: 10, identity: 0.688

ccgaacgagctgctcaccgactccctcatcag	CRISPR spacer
aggaacgagatgcgcaccgactcccagccatg	Protospacer
  ******* *** ***********   .  *

173. spacer 20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030052 (Bradyrhizobium guangdongense strain CCBAU 51649 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.688

ccgaacgagctgctcaccgactccctcatcag	CRISPR spacer
aggaacgagatgcgcaccgactcccagccatg	Protospacer
  ******* *** ***********   .  *

174. spacer 20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP030054 (Bradyrhizobium guangzhouense strain CCBAU 51670 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.688

ccgaacgagctgctcaccgactccctcatcag	CRISPR spacer
aggaacgagatgcgcaccgactcccagccatg	Protospacer
  ******* *** ***********   .  *

175. spacer 20.4|8053699|32|CP033073|PILER-CR,CRISPRCasFinder,CRT matches to NC_024972 (Micrococcus sp. A1 plasmid pLMA1, complete sequence) position: , mismatch: 10, identity: 0.688

ccgaacgagctgctcaccgactccctcatcag	CRISPR spacer
cctaaccagctgctcaccgactcggcggaacg	Protospacer
** *** ****************  . .   *

176. spacer 9.3|3575364|32|CP033073|PILER-CR matches to NZ_KY349138 (Mycolicibacterium sp. CBMA 213 plasmid pCBMA213_2, complete sequence) position: , mismatch: 11, identity: 0.656

tttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
agaaagcccggcttccagaagccggtgacgcc	Protospacer
     ************* ****.****    

177. spacer 9.3|3575364|32|CP033073|PILER-CR matches to NC_019789 (Deinococcus peraridilitoris DSM 19664 plasmid pDEIPE01, complete sequence) position: , mismatch: 11, identity: 0.656

tttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
gccaccgccggcttccagacgccagtgaacac	Protospacer
 .. .  ***********  **********. 

178. spacer 9.3|3575364|32|CP033073|PILER-CR matches to NZ_CP020332 (Martelella mediterranea DSM 17316 strain MACL11 plasmid pMM259, complete sequence) position: , mismatch: 11, identity: 0.656

tttttgcccggcttccagtagccagtgaacgg	CRISPR spacer
gcgccatccggcttccagtagatagtgaaccc	Protospacer
 . ....************** .*******  

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	3647798 : 3655662	7	Streptomyces_phage(66.67%)	NA	NA
DBSCAN-SWA_2	4175120 : 4231425	35	Lactobacillus_phage(33.33%)	integrase,tRNA,protease,transposase	attL 4173407:4173430|attR 4189623:4189646
DBSCAN-SWA_3	7900224 : 7954363	44	Paenibacillus_phage(100.0%)	integrase,protease,transposase	attL 7938953:7938971|attR 7960036:7960054

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>CP033073|3647798:3655662|DBSCAN-SWA
TGTGGTCTGGGACACAACGGACACCCTTCGAAAGGGAGATGTCGTGAGCAACGAGAGCCTGGCCAACCTGCTCAGGGAAGAACGCAGGTTCGCGCCACCCGCAGACCTGGCAGCGCGAGCCAACGTCACCGCGGAGGCGTACGAACAGGCCAAGGCTGACAGGCTCGGCTTCTGGGCCGAGCAGGCCCGCCGGCTGACCTGGGCCAAGGAGCCGACCGAGACGCTGGACTGGTCGAACCCGCCGTTCGCCAAGTGGTTCAAGGACGGCGAGCTGAACGTCGCGTACAACTGCGTGGACCGGCATGTGGAGGCCGGACACGGGGACCGCGTCGCGATCCACTTCGAGGGCGAGCCCGGCGACAGCCGGGCGATCACCTACGCGGAGCTGAAGGACGAGGTCTCCAGGGCCGCCAACGCCTTGCTGGAGCTGGGCGTCCGCAAGGGCGACCGGGTAGCGATCTACATGCCGATGATCCCCGAGACCGCGATCGCGATGCTGGCCTCGGCCCGGATCGGCGCCGCCCACTCGGTCGTCTTCGGCGGCTTCTCGGCGGACGCGCTCGCCACCCGGATCCAGGACGCGGACGCCAAGGTCGTCATCACCTCCGACGGCGGCTACCGGCGCGGCAAGCCGTCCGCGCTCAAGCCGGCCGTGGACGAGGCGGTCCAGAAGGCGGGGAACGTCGAGCATGTGCTCGTGGTCCGCCGTACCGGGCAGGACGTGGCCTGGAACGCCGAGCGGGACGTGTGGTGGCACGAGCTGGTCGGACGGCAGTCCGACCAGCACACCCCGGAGGGGTTCGAGGCGGAGCACCCGCTGTTCATCCTCTACACCTCCGGTACGACGGGGAGGCCGAAGGGCATCCTGCACACCTCCGGCGGCTACCTCACCCAGGCGGCGTACACCCACTGGGCCGTGTTCGACCTCAAGCCGGAGACGGACGTGTACTGGTGCACGGCCGACGTCGGCTGGGTCACCGGGCACTCGTACATCGTCTACGGCCCGCTGGCCAACGGCGCGACGCAGGTGATGTACGAGGGCACGCCGGACACCCCGCACCAGGGCCGGTTCTGGGAGATCGTGCAGAAGTACGGGGTCACGATCCTCTACACGGCACCGACCGCGATCCGGACGTTCATGAAGTGGGGAGACGACATCCCCGCCAAGTTCGACCTGTCCTCCCTGCGCGTCCTGGGCTCGGTCGGCGAGCCCATCAACCCCGAGGCCTGGATCTGGTACCGCAAGCACATCGGTGCCGACCGGACGCCCGTGGTGGACACCTGGTGGCAGACCGAGACCGGCGCGATGATGATCTCGCCGCTGCCGGGCGTCACCGAGGCCAAGCCCGGTTCCGCGCAGCGCGCGCTGCCCGGCATCAGCGCCACGGTCGTGGACGACGAGGCGAACGAGGTGCCCGACGGCGGCGGTGGCTACCTGGTGCTGACCGAGCCGTGGCCGTCGATGCTCCGCACCATCTGGGGTGACGACCAGCGGTTCATCGACACCTACTGGTCCCGCTTCGAGGGCAGGTACTTCGCCGGGGACGGCGCGAAGAAGGACGACGACGGGGACATCTGGCTGCTGGGCCGGGTGGACGACGTCATGCTCGTGTCGGGGCACAACATCTCCACCACCGAGGTGGAGTCGGCGCTGGTCTCGCACCCGTCGGTCGCCGAGGCGGCCGTCGTCGGTGCCGCGGACGAGACCACCGGCCAGGCGATCGTCGCCTTCGTGATCCTGCGCGGTACGGCGTCGGAGGACGAGGCGCTCGTCGGCGCGCTGCGCGACCACGTCGGCGTCACGCTCGGCCCGATCGCCAAGCCGAAGCGCATCCTGCCGGTGGCGGAGCTGCCGAAGACCCGCTCGGGCAAGATCATGCGCCGACTGCTGCGCGATGTGGCCGAGAACCGCCAGCTCGGCGATGTCACCACGCTGACGGATACCGATAGCTTGCGTCGCATCGTTGACAGTTTGAAGCCGACGTCGTCAGCCCAGGAAGACGAGTAGGAGTCCACGCTGAAGGGCCAGGACCGGATCACCGGTCCTGGCCCTTTCGCTTTGTCTGACCCGCTACTACCGGGGGCCGTACTCTCGAATCATGAGCGCCAACCTGGGTGAACGGCTCCGGGGAATCCGGAAGCACAGGGGACTGAGCCAACGCGAGCTCGCCGACCTTTCCGGCGTGTCCCTCTCCCTCATCCGGAAGCTGGAGCAGGGCGAGCGCAACGAGACACGCCTGGAGACGGCCCGGCAACTGGCCCACGCACTGAAGGTGCCCACCACCCGGCTCGTAGCCGAGCACGCAGAGGCCTCCGCGGACTCCACCGTCGTTGATCGCTGGGCGCCCGTACACGCCGCTCTCGCGGCCTCTCCCGAGCCCGATGGACTGGACGAACCACCCACCTACGACGGCGTACGAGACGCGCTCACAGCCGCCGTGCCCCTGTTCTCCCACGACCGCTTCGCCGAGCTCGGAACAGCCCTCCCTCCCCTCCTCCGGGATGCCGAACTCCTGGTCGAGACCGACAGCCGCGCCCGACCCCTCCACGCACGCCTGCTGGAACTCACCGGGTGGCTGATGACCCAGACCCGACAGTTCGACGCCGCCGAAATGGCCCTGGAGCGGGCTCTGGACGACGCCACCGACCGAGTACAGGGCGCCTCGACCGTCAGCGTCCAGTGCTGGCTCCTGCTGCGCCGCGGAAGGCTCGCCGAGGCACGCGAGCTGGCCGTCGAGTGGGCCGACGAGGTCGAACCTCGCATGTCCCGAGCCACACCGGCCGAACTGAGCACCTGGGGCTGGCTCCTGCTCCGCATGTCGGCCGCCGCCATCCGCGACAACCGTCCGGGCGAGGCCGAGGACGCCCTGCGCCTGGCGCACTCCGCCACGGTGGCCCTGGGGCGGGAGTGCACCCCCGAGGAAGACTTCCTGCGCACCTTCGGGCCCGTCACCGTGGCCCTGAAGCGCACAGAGAACGCGATGGTGGCCGGTCAGCCCGACAAGGTGCTCACCCTGGCCTCGCGCATCCCTGCGGACAGCCTGAAGCCCACCTCGAACAACCGGAACAGGCACCTGCTCGACGTCGCGAGCGCACAGACACAGCTACGGCAGTACGCCGAGGCCGTCGACACCTTCCAGAAGATCCGGGCCGGCTCCCCGCAGTGGCTGCCGAACCAGCGCTACGCCCGCGACGTCCTCGGCCGCATCGTGAGCAAGCGGCGCACCCTCACGCCCGACATGCGCGAGCTCGCGGACCTGGTGCACTTGCCGGTGTGACACTGTGTGGCACTTCCGTCTGACGCCCCGCCAAAGTGCCATCGACGCAGGTCAGCGAGCTCCGTAGCGTCGGATGCGTGGCGAACGAAACAGTGCACGAAGACGCGAGCGGCAAGGTGGGATCGCCGAGACTGCTGCCCTGGACTCACGACGGCAAGACGTGCTGGCTGTCAGCCGCCAGCGAGGGCGGCATGTTGTCCAGCATGGCGGACGCGATGGAAGCCGAGCAGATGCGCGACGGCCGCGAGGTGCTGGCCCAGGCTCGCGGTCTGCTCGAGGCGTCCGACAAGCTCGGCGTCCACGAGCTGAGGTTCATCGCCTCCCGTCCGGCCGAGGGTCTGTCCGACGCGCTTCGAGTGGCCGAGTCCCGCGGCATCCGCCTCGGGATCGTCGACCCCACCCCTGACGACGACGCTGAGGAGATGGACGACGAGGGGCTGAAGGCCGGCGAGTGACCGCCCCGCCGGCCGACAAGCCTCGGGCCGGGCGCAGGGGGTACGACGACGGGCCGCCGTCCTTCATGGAGTGGTTGCACTCCATCTCGGACATCTGCGGCACGTGCTACGGCCATCGGTTGGTCTGGTGTCCGTGCTGCCTGGGGTTCGACGGGTGCTCCGCCTGTCACATGCAGACTCAGGTGCCGTGCCCGGACTGCGCTGGCGGCGACCTGTTGCCGGCGGTGTACTGAAAGCACCCTGCCCCAGCGCATCCCCCCGAGTCGCTGGGGCAGGGCCTTTGTGCCTCGAAAAAACATTCGGTCCGAGGTGCTGATGGCCCCCCTCCGCGTGCTACAGATTGGATACCGCCTGGGGCGGGGGCCCCATGATCGGCGGGAGAAGGACACGCGAGTACATCGCGGTAGCTTCTGTCCCCCTCTCACCGAAAGGTCATCACAATGACCGGACCCCGGTTCGGCGCCGGCATCCCCTCGCGGAAGGGAGCTCGGTGACCGCCAACCAGAAGAGGCTCGTCTCGTACGGGTTTGCTTTTTGTATTGCGATCATCATCGGGGGTGCCTGCGCGGCCGTGGTCGTCGCGCTCAAGGCCCCCGGACTTACGATCGCCGGGGCGTTTGCCGCCGGCTTCCTGGGCATCATGGGCGTCGCCGTGAAGGTGATCGGCCCCTTCGACTTCAACGACGACAATGCTCCCCCTCCCGCGGAGCAGGAGAAGGAGCATTCGGCGAAGTGATCAGCGGACGGGGCAGGCGCCGGTCGAGCACTCCTCGTCGGTGACGTCCTCGACCGAAGTCACTGCGTACTGAGCGAACTCCTCTTCGGTGATCCGCTCGTACGGAGCTTGAGCGCGAGTGCCGTCCGGCATCAGGGTCGTGCCCTTCAGGTCCGGGAGCCACGACTGGATGATCGCGGCGGCCTCGGCGACCAGCTTGTCCTTGGTGGGGTAGGTGACCACCATCGTGTTGCCGGACTGGTCGTAGATGCACTTCTCGACCTCGAAGCCGGCGAGCACGGCGTCCTCGACGGTCTTGGCCTGCGCCGGGTCGGGCATCGAGAACCGCACGCGCCGCTTGAAGTGGCGGGCGTAGATCGGGTGGATGCCCTCGGTCACGCCCGGCATCTTCGCGATCGAGCCGGTCGGCGCCTCGGTCGTCACCTTCACCGGCTCGGGCACGCGGAGCTGGAAGGCGTACTCGCGGGCCTCCTCGCGCACGACGTCATACAGGTCGTTCAGCAGGTTGCGGACGTCGTACCGGTACGGGGCGTCGGAGTAGCGGATGCCCTGCTTGGCGAGGAACCCTTGCACGCCGAGGTGGCCGACGCCGATGCGGCGCTCGGTGTGCATGACGTGGCGCTGCTGGTCGTCGGTCATGTCGCCGTAGGTGGCCCGGATCAGGAAGCGCGTCATGAGCTGGTGCGCCCGCTCCAGTCCCGCGCGGTCGATTCGTGCGCCCCTCACCTTGGGGGCGAAGGCGTCGAGGTTGACGTGGCCGAGGACTACCGGTGCCAGAAGGTTCGCGAGGGAGTCGAGTACCAGCACGAGTGCCAGCCCCTGTACGCAGACGACGTCGAGCAGGCAGTCATGGCCCAGGTGACCGACCTGATCAGCGACCCGGACCGGCTGCACGAGCTGATCGAGGAAGCCCTCGGCACCACCCCGAACCGGCTCGACTCCTACCGGCGCCGGCTGGCAGAGATCGACGAGACGCTGGCGAAGAAGCGCAAGACCAGGAAGAAGTCCATCGCCCGGCTCGTCGCGGCGATGGATGTCGACGACGAGGACGACGACGACTTCGCCGAGGAGATGCGTCAGGAGATCGAGGAGCTGAAAGGCCGCTACAAGGAGGAGGAGGAGGGCACCCTTCTCCAGGAGCGTGAGCGGGTCGAGTCCTGGATCGCTGACTGCGAGGGCGAGGAAGAGGTGGCCCTGCGGGTGCTGGCCGCCGCGGACAAGCTGCGCAGCAAGGTGGGCAAGCTGTCCAAGCGGGAGCAGGCCGACCTCATCGAGATGCTGGACATCCAGGTCCAGGTCGAGGGGACGGCGAAGGTGCACCGCGCGGGCAACATGGACCCGATCTTGAAGTGGCACTGGGACACCGGCACGGAGGTGCCGGCCGAGCTGAGCGACGAGCTGTGGGAGAAGGTCTCCTCGATCCTGTCCTACAAGCAGAAGTGGAAGGACGTGCGCGGGGCGGACGGTCCGGCGGTGGGATGAGAGCGGCGAGTACCGGCAGGCGCTGAAGGTTCTGGCCCCGTACCGCAAGGTGCCGGCTGCACCGCAGTTCTCCCTCCCGCCCATGCGGATCACGGGTGCTGTGGGTGCCGCTCCGAGCGGTGCTTCCGGTGGTCAGACCGATGGTGTAGCAAATGGAGAACTTGGGGACGCAAGAGCACAGGGTCCACGGACTCCACGGTCATGGATTTCATCCAGGCCAAGCTGCCGGCCGCGTCGAACGAGGACTAGGCCGTACGGCGCCACAGCAGGGGGAGGGGGCGTCCGGTGCGGTCACCGGGCGCCCCCTCCTCGTCCGTCCCACGGGCCCACGGCTCGTCCGTCCCACGGGCCATCGATGTCATAGCCGGGTAAAATGGCAGCTCGGGCGTGCCGGGAAGTCTGGTCGGCAGGGCCGTCGGCGATCCCCGCGACGGCCGGAACTTCGTCGTACCGACTCGGAGGTCTGCCGTGACCGCGCCGTCCCGCCCCCCGAACCCACCCCGCAAGGCGCTCGGACGCCTGTCCCTGCCCGAGCGGAACTTCGTGGCGGAGGCGCTGCGCACCGAGACCACCGGCGGTGTCCTGCTGCTGCTCGCCGCGGTCGCGGCGCTGGCCTGGGCGAACATCCCCGCCCTGCGCCACAGCTACGACACCGTGAGCGACTTCCCCTTCGGCCCCGGCGCCCTCGGCCTGCACCTCTCCGTCGCCCATTGGGCCGCCGACGGCCTGCTCGCGGTGTTCTTCTTCGTCGCCGGCATCGAACTCAAGCGCGAGCTGGTCGCCGGCGACCTGCGCGATCCCCGGGCGGCCGTGCTGCCCGTCGTGGCCGCGCTGTGCGGGATGGCCGTACCCGCGCTCGTCTACACCCTGACCAGCCTCAGCGGCGGCGGCACCACCCAGGGCTGGGCGGTGCCCACCGCCACCGACATCGCCTTCGCGCTCGCCGTGCTCGCGGTCATCGGCACCTCGCTGCCCAGTGCCCTGCGCGCCTTCCTGCTCACCCTCGCGGTCGTCGACGACCTGTGCGCGATCCTGATCATCGCGGTCTTCTTCACCGACCGGCTGAACTTCGCCGCGCTCGGCGGGGCCGCCGCCGGCCTCGTGGTCTTCTGGCTGCTGCTGCGCAAGGGGGCACGCGGCTGGTACGTGTACGTACCGCTCGCGCTCGTCATCTGGGCGCTGATGTACAACAGCGGCGTGCACGCCACCGTCGCCGGCGTGGCGATGGGCCTGATGCTGCGCTGCACCACCCGCGAGGGTGAGCGGCACTCGCCGGGCCAGCGCATCGAGCACCTGGTGCGACCGCTGTCGGCCGGACTCGCCGTCCCGTTGTTCGCGCTGTTCAGCGCCGGCGTGCCGGTGTCCGGCGGGGCCCTGCGGGACGTGTTCACCCGACCGGAGACGCTCGGGATCGTACTCGGTCTGGTCGTCGGCAAGACGGTCGGCATCTTCGGGGGCACCTGGCTGACCGTCCGCTTCACCCGGGCCCGGCTCGGCGAGGACCTCCGATGGGCCGACGTTTTCGCGGTGGCGTCCCTCGCCGGCATCGGCTTCACCGTCTCGCTGCTCATCGGCGAGCTGGCCTTCGACGGCGACGCGGGGCTGACGGCCGAGGCGAAGGCGGCCGTCCTCACCGGATCGCTGATCGCGGCGGCGTGGGCGACGGTGCTGCTGAAGATACGCAACGCCCGCTACCGCCGGCTGTGCGAGGAGGAGGACCGCGACGACGACCTCGACGGCATCCCGGACATCTACGAGCAGGACGACCCGGCGTACCACCTGCGGATGGCCCGGATCCACGAGCACAAGGCCGCCGAGCACCGACGCCTGGCCGCCGAGCGGGCGGCCGAGGCGCGCCACGGGCTTGCGGAAGTACCGGGTGGGGCAGGCGAGGAGGGCGACCGTCCGGCATGA

Protein sequences of DBSCAN-SWA_1

>CP033073|3647798:3655662|3651167_3651530_+|AYN40205.1|DBSCAN-SWA
MHEDASGKVGSPRLLPWTHDGKTCWLSAASEGGMLSSMADAMEAEQMRDGREVLAQARGLLEASDKLGVHELRFIASRPAEGLSDALRVAESRGIRLGIVDPTPDDDAEEMDDEGLKAGE
>CP033073|3647798:3655662|3647798_3649805_+|AYN40203.1|DBSCAN-SWA
MVWDTTDTLRKGDVVSNESLANLLREERRFAPPADLAARANVTAEAYEQAKADRLGFWAEQARRLTWAKEPTETLDWSNPPFAKWFKDGELNVAYNCVDRHVEAGHGDRVAIHFEGEPGDSRAITYAELKDEVSRAANALLELGVRKGDRVAIYMPMIPETAIAMLASARIGAAHSVVFGGFSADALATRIQDADAKVVITSDGGYRRGKPSALKPAVDEAVQKAGNVEHVLVVRRTGQDVAWNAERDVWWHELVGRQSDQHTPEGFEAEHPLFILYTSGTTGRPKGILHTSGGYLTQAAYTHWAVFDLKPETDVYWCTADVGWVTGHSYIVYGPLANGATQVMYEGTPDTPHQGRFWEIVQKYGVTILYTAPTAIRTFMKWGDDIPAKFDLSSLRVLGSVGEPINPEAWIWYRKHIGADRTPVVDTWWQTETGAMMISPLPGVTEAKPGSAQRALPGISATVVDDEANEVPDGGGGYLVLTEPWPSMLRTIWGDDQRFIDTYWSRFEGRYFAGDGAKKDDDGDIWLLGRVDDVMLVSGHNISTTEVESALVSHPSVAEAAVVGAADETTGQAIVAFVILRGTASEDEALVGALRDHVGVTLGPIAKPKRILPVAELPKTRSGKIMRRLLRDVAENRQLGDVTTLTDTDSLRRIVDSLKPTSSAQEDE
>CP033073|3647798:3655662|3649896_3651075_+|AYN40204.1|DBSCAN-SWA
MSANLGERLRGIRKHRGLSQRELADLSGVSLSLIRKLEQGERNETRLETARQLAHALKVPTTRLVAEHAEASADSTVVDRWAPVHAALAASPEPDGLDEPPTYDGVRDALTAAVPLFSHDRFAELGTALPPLLRDAELLVETDSRARPLHARLLELTGWLMTQTRQFDAAEMALERALDDATDRVQGASTVSVQCWLLLRRGRLAEARELAVEWADEVEPRMSRATPAELSTWGWLLLRMSAAAIRDNRPGEAEDALRLAHSATVALGRECTPEEDFLRTFGPVTVALKRTENAMVAGQPDKVLTLASRIPADSLKPTSNNRNRHLLDVASAQTQLRQYAEAVDTFQKIRAGSPQWLPNQRYARDVLGRIVSKRRTLTPDMRELADLVHLPV
>CP033073|3647798:3655662|3652020_3652266_+|AYN40207.1|DBSCAN-SWA
MTANQKRLVSYGFAFCIAIIIGGACAAVVVALKAPGLTIAGAFAAGFLGIMGVAVKVIGPFDFNDDNAPPPAEQEKEHSAK
>CP033073|3647798:3655662|3653115_3653748_+|AYN40208.1|DBSCAN-SWA
MAQVTDLISDPDRLHELIEEALGTTPNRLDSYRRRLAEIDETLAKKRKTRKKSIARLVAAMDVDDEDDDDFAEEMRQEIEELKGRYKEEEEGTLLQERERVESWIADCEGEEEVALRVLAAADKLRSKVGKLSKREQADLIEMLDIQVQVEGTAKVHRAGNMDPILKWHWDTGTEVPAELSDELWEKVSSILSYKQKWKDVRGADGPAVG
>CP033073|3647798:3655662|3654216_3655662_+|AYN40209.1|DBSCAN-SWA
MTAPSRPPNPPRKALGRLSLPERNFVAEALRTETTGGVLLLLAAVAALAWANIPALRHSYDTVSDFPFGPGALGLHLSVAHWAADGLLAVFFFVAGIELKRELVAGDLRDPRAAVLPVVAALCGMAVPALVYTLTSLSGGGTTQGWAVPTATDIAFALAVLAVIGTSLPSALRAFLLTLAVVDDLCAILIIAVFFTDRLNFAALGGAAAGLVVFWLLLRKGARGWYVYVPLALVIWALMYNSGVHATVAGVAMGLMLRCTTREGERHSPGQRIEHLVRPLSAGLAVPLFALFSAGVPVSGGALRDVFTRPETLGIVLGLVVGKTVGIFGGTWLTVRFTRARLGEDLRWADVFAVASLAGIGFTVSLLIGELAFDGDAGLTAEAKAAVLTGSLIAAAWATVLLKIRNARYRRLCEEEDRDDDLDGIPDIYEQDDPAYHLRMARIHEHKAAEHRRLAAERAAEARHGLAEVPGGAGEEGDRPA
>CP033073|3647798:3655662|3651526_3651763_+|AYN40206.1|DBSCAN-SWA
MTAPPADKPRAGRRGYDDGPPSFMEWLHSISDICGTCYGHRLVWCPCCLGFDGCSACHMQTQVPCPDCAGGDLLPAVY

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYN40203.1|3647798_3649805_+	acetate--CoA ligase	A0A2H4PQU7	Staphylococcus_phage	1.5e-85	41.1
AYN40204.1|3649896_3651075_+	XRE family transcriptional regulator	A0A291LIG4	Streptomyces_phage	2.6e-183	82.9
AYN40205.1|3651167_3651530_+	hypothetical protein	A0A291LIC9	Streptomyces_phage	2.9e-48	79.2
AYN40206.1|3651526_3651763_+	hypothetical protein	A0A291LHE9	Streptomyces_phage	1.3e-17	75.0
AYN40207.1|3652020_3652266_+	hypothetical protein	NA	NA	NA	NA
AYN40208.1|3653115_3653748_+	hypothetical protein	K4HZQ1	Streptomyces_phage	5.2e-69	76.5
AYN40209.1|3654216_3655662_+	Na+/H+ antiporter NhaA	A0A2H4J5W3	uncultured_Caudovirales_phage	2.6e-60	41.3

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>CP033073|4175120:4231425|DBSCAN-SWA
CTTACTTAGCGCCATTTCGAGGGCGGCGGGGGACCAACGAAGCCGCCTTCTCCGCGATCTCACGGTCGAGCTCAGGGAGCAGGCTCGTGTACGTGTCCGAGGTCAAGGTGATGGTGGAGTGCCTCAGCGTCTCCTTCACCGTGTGGATGTCGCCGCCACCTCCGTGCGTGAGCGTCGCGGTGACGTGGCGTAGGTCCCGCAGGGTGATGGGCGGCAGGTTGGTCGTGGCGAGGATGCGGCGGAAGGTCTCGGAGACCGTCCCGGGGTGGAGCCACGAACCGTCTTCCTTCGTGAAGACCTTGCCGGTGTCCTGCCAGGCTTCGCCCCACTTCGCGCGCTCCTTCTCCTGGCGGGCTTTGTGGTCGCGCAGTTCGGAGATGGTCGTGCTGTCGAGCGCGATCGTGTTGGCGCTGCCGTCCGTCTTGGGCTCGGATTCGTAGGGGTCCCAGCCGTCCACCACGATCTCCTTGGCGGGCGTGATGAGGCCGGCGTCGAGGTCGATCTCGTGCCAGTCCTGGCCGACCGCCTCGCCGCGACGGAGGCCGCGAGTACCCATGAGGTGGAAGATCGCGTACAGGCGGTCGCCCTCGGCTGCGTCGAGGAAGGCGCCGAACTGCTGCGGGGTCCACACCATCACGGGGCCGGGTATCTCGCCCGTCTCGCGCCAGCGCCGGACTCGTTCATCGGTCCAAAGAAGGGGCTTCGGGCGCTTGCCGGACTCCAACTCGACGTGGGACGCCGGGTTGAAGGTGACGAGCTGCTGGGCGATCGCGGAGTTCAGGGCCGCGCGTAGGGTGCGGCGGATCGCCTGACGGGATGCCGGGCCGGTGATCTTCCGGAACGGCTTCATCTCCGCCAGCTTGGCGCGCTCGACCGCGAGCAGCTTCCGCTCGGCTCCAACGGGGCGGCCGGGCTTACTCGGCTTGCAGCGGGCGATCTGCTCGCGGCGGGCCCCGTTCTCGGCCGCGATGACCTCGTTGTCGTCGGCTATCCCGTCGAACATCTCAACGAGGTGGCCGACGTTGAGGCGGTCGAGGCGTACGTGGCCGATGCGCGGCTTCAGGTGGACGCGGATGTGGGAGGCGTAGCCGTTGAGTGTGGTCTTACGGCGCTTCTTCGCGGCGAACCACTGGTCGAGCCACTCGCCGACGGTGAGGCTGCCACGGAGGGCCAGGCCCGCCCGCAGACGGCGTCGGGTCTCCTCGAGGGCCGGCAGCGGGGCTTTCTCGGTTCCGACCGCCTCCAGCATGTCCACGAGGCGCTGGAGGCTGTCGGGGTCGTCCTTGTCCGCCAGGGCGAGCAGCGAACGGACGTGATCGAGGTCCGCCTGGGCGTCCTTCAGCGACTCGTAGCCGGCGCGGCTGAAGGAGCGGCGGGTGCCGTCCTCGTGGGGCGGGAGCTCCTGGCGTATGGAGTACGAACCGTGCTTGCGACTAGAGAGCTTGGGGCAGGACTTGCCGAGCGGCTTGCCGGTCTCAGCGTCACGGCAGTAGCAGCGGCGGTGGGTGGAACCCTTCAAAAACCGTTTTCCTCGTTGGTGTTGGCGTCACTTCGGGGCGGGTCGATATCGGCGAGTTCGGGCGGCAGCGAGGGGGGAGTGCCACCGTCGGCGCGAATTAAGGCACGCGCGCTGCGCAGCCGGTACTTGGCGTCCAGGGCTCTTTCGGCGTAGGCGGCCTGGGCGAGTGTGGCCTCCTCGCGTTCGGCCTGGTTGGGTGCGGTCTCGGCTTTCCAGCGCTCGTGCTTCTCGCCCTTCAAGGCGGCCAGGGCGGCGCGCTGGTGGCTGGCGTGGGCGCGGAAGGCGCGGAGCATGTCGTCCTCCATACCGAAGCCCTCGCTGTCGCCGGTGAACCAGTGCAAGGCGTCCCATGTCGCCTCGTCGTCCCGGAGTGGTAGCCGCTGAACCCTCTCGACATAGCCGACTGGATAGAGCAGGCAGATCGGGTAGGTCTGCAGGGCCTCGGCCAGCACCATGACCTCGACCAGGGGCAGCGTTGAGCGGCGGCCGGACTCCATGTTGGCGATCACATTGCGCGGGATCGGATAGCCGATCTCCTCGCATTTGTCTGCCAAGTCCTGGGCGCTCATGCGCAGTTCCTTTCTCCGCCTGCGGACCTCGGCGGCCACGGTGGCCGTCACCTGATCCGCCCACTCCGGGACGTCGTCCTCGTCCCTACCAGCATCGAAATCGTTTTGTGTCATGAAGACACATTAGCTCGCCGATGATGGTTATTCGTGGCCTGGAGCCGGACGTGACGCCGCGTTCGCCGAGGGCTCACTCAAGGATGGAGCGTCGTATGCGCAATGACGAGACCGACCGGGAGTCGAAGGGCATGACGCGGGAGGAGCTGCTGACCCTGCCCGTAGCCGTTGACCTGGACACCGGCAATCGGGCGCTGGGGCTGGGGCGGAGTAAGGGCTACGCGCTGGCCAAGCGCGGCGAGTACCCGTGCAAGGTCCTGCGGCTGGGCAACGCGTACCGGGTCGTGACGGCCGACCTGCTGGATCTGCTCGGCCTGGCAGCGTGAAGGGGTGGCAACGTAGCAGACGCTTCTGCGCTGAGCTGACACAGAAACGCTGGACTGTGACCGGGCGTGGACGTACTGTCCGTGGTCCCTCGCCCCGGCCGCGGAAGCGAGAGAGCCTCCGGCGCGCCAACGCCGGAGGCTCAGCACACTCCACTGCCCGCATTCCAACAAACGACCTGCGTGACCCGGGTCTGCATGCCCGAAGTCACCGGATAGGAGCTGCCCTGTGCAACCTACGACACCCGAGCCGGATTCCGCACCGGCCGAAGTCGTATGGCCGACGGCCGCGGTGCCTGGTCGCCCCGGTTACCCCCCGCCCGAAGCCGCTCCGGCGACCGACGACAGGGCACCTGATCCTGTACCGGCCGATGAGCCGGCTGAGGAAGCAGTGCCAGACCCAGATTCAACGTACGGCTCCGCGCTGCTGGATGAGCTACGTGCTCGGATAGCCAAGTTCGTGATCCTGCCCTCCGAGCAGGCGCTGGACGCCGTCACGCTCTGGGTGGCGGCCACCCACCTGCAGCCCGCCTGGCAGCACGCCCCACGTCTGGCGGTCGTCGGGCCGGCGAAGCGGTGCGGCAAGTCACGGCTCCTGGACATACTCACCGAGACGGTCCACGAGCCGATGCTCACCATCAACACCACGCCCGCGGCGGTCTTCCGCTCCATCACCGACGAACCCCCCACTCTGCTGGTGGACGAGGCGGACACCATCTTCGGCACCCCGAAGATGGCGGAGAAGAACGAGGAGATGCGCGGCCTGCTCAACGCCGGCCACCAGCGCAACCGCTACGTAACCCGCGTCGTCGGCAACGACCACACACCCCACAAGTTCGCCACCTTCGCCATGGCCGCCCTGGCCGGGATCGGTGACCTGCCCGACACGATCATGGATCGGTCCGTGGTCATCCGTATGCGCCGCCGAGCCGAGGGCGAGAGCGTCAAGCCCTTCCGCTCCCGCCGCGACACCCCCGCCCTCCACGACCTGCGCGACCGCATCGCCGCATGGGCCAGGCCCCTGCTCGATGAGGCCGCCGACCTGGAACCGGCGATGCCGGTCGAGGACCGCGCCGCCGACACCTGGGAGCCCCTGGTGATCGTCGCCGATCTCGCTGTCGGGTCCTGGCCCCGTCGCTCTCGCGAGGCATGTGCGCGGATGGTGGCTGCGGAGGTTGAGGTGGAGGAGGAACAGCCCGGCGGAGCACGGATCCTCGCCGACATCCGCAGTGTCTTCGTCGCCCAACGGGAGGTAGACAGCCTCTCCACGGACGAACTGCTGCACCACCTTCGGCAGAACGCCGAAAGCCCCTGGGCGGAATGGGGACGCAGCGGGCTGACCGCCCGGGACCTTGCAAGGATGCTGAACCAGTTCGGCATCAAACCCGGCAACGTCCGCCTCGCCGACGGAACCCAGCGCAAGGGCTACATGCGGAACAAGTTCATCGACGCATGGCGGCGCTACTGCCCCACCGTCCACCCGGTGGACACCGAACCCGCTGCCGCAGTGGGCTGAGCCCCCGCACCCCCCCAGTGGCCGTCCCTGCCGTCCCTGCCGTGATTCCCCAGGTCAAACGGCATATGGGCAAGACGGCAACCAGGGACAAGACGGCAGCGCGATCACGAAGACCGCGCTGCCTCCGCCAGCGAACCGCCCGGATCCGTCTCGTGCCGTCCTGGGCGTCCCCGCCGTATCACTGCGCAGGTCAAGGCCCCGTCGGTCGGGACGGAGTGACGCAAGAGCCCCGTCCCGGCCGACACAAAGGACACGCGCTGGGACGGCAAGCCGAAGCCACTGCCGTACCCGCGCTGACCTGTGCTTGCAACGGCCAAGACGGCTAAGACGGATTACACCGCCACCCCCACCCAGCCGAAGGGGCCGATCGTGGCACCGGCCGAGCGTGCCTCAGCAGCTTGAGCGATGCGGTCGAGCGCGTCCTCGATTTCGGGGGTGTCCTGCCACCGATCGGCCTTCCGGAGTAGGCCGAGGTGATCCAGGGCTCGTGTCGGGAGGCTACGCAGCCGTTCCTGATCGAGGACCGGCAGCGCGGCTGCCATGCGGGTGCTGTGCAGGACCACGGCTGCTGCTGCGCCGTCGAGGTCGTCCGCCTCACGGATGGCGGGGCCGAGGTCTTCCAGCAGCATCCCGAGCCAGCCGTCCCGGACCGCGGAGGCGTGAACGGCAGGCACGGGAACGCCGAGCGAGTCGGCCAGGCGGAGCGCGTGGTCCTCGTTCTCGAAGGGCCTCTTGGCGTACTTGAAAATGGCCGTGGTGCCGTCGGTGAAGGCCAGGCGCTCGACGCCGGACATGGACCAGACACGCACCTCTTCACGTGATGGCGAGGTCCGGCCGGCGATGGTCAGCAGGTTGTCCAGGAGTGCGGCGTTGAGGGTCGCGTCCATGAGGGAAGCTCCGGTGCGGTTGGAGGCGTCCGGGGCAGGCGAGAAGTGCCGGCCCGCCCCGGAGCCTGGCGTGCGGTGGTTACGCGGCAGGGCTCACGCGCTGGGCGTAGACCCGCTCGATCCAGCCGGCCTTGAAGGCCGCGAGGTCGTCGCGGAAGGCGCTCATCGAGGCACCGTAGGGCGCGACGACACCCCCGGTCTGGTCCGGTACGGACTGGCAGCCGTGCACGAGCCGGCCGCCGAGGGCGGCGTGGGCCTTGATGGACTCGATGCGGCGGTGCTCGTTGAACCAGCCGCCGTGGTAGACCTCGTCGAGCGTCCCGCCCATCTCGTCGTCCAGGTCGAAGACGACGGAGGTGGCGGCGGGGAAGAACCAGCACGGGCCGACGTTGGAGATGTGCCCGTCCAGCTCCACCTTGTTGAGGGCCATCAGCGTCGCGGCCTCACGCAGCATCCGCAGGTGGTCGGCGGTGATCTGCGGCAGTCCGAGGCTGGCCAGGTGTTCGTCGCGGAAGAGGTAGGCGTACACCTCGTAGGCGGTGGCGAGCACACGTGTGGCGTCCGAGGTCGACCCGGCGTGGGCCTTGATGAAGTCCAACGCGAGCTGCTCGACCGCGCTCTCGGTGGTTTCCTGCACGTCCAGGAGCTGGGCCTTGACCAGCTCCCAGTCGGCGACGAGCCAGGTGTTGGACTCGAAGCGGAAGAAGTACTCGGCGGGGTCGATAGTGATGCGCCGGCCGTCGACCTGGACGCCGGGCAGTCGGCTCCAGCGCTCGTCGAACGCCTCGGGCAACTCGACCGTGATGGCCGTGGTGTCGATGGTGGTCACCGTGTCTCCGTCTCTGATCGGCCGAGTTCGGGCACGGTGATGCCCGAACCCGGAGCGGTTGTATGGAACTTCGGGGAGCCGCCCGACCGAAGGGGGGAACCTGGCCACTGTGTCGGACCGTGCCGGGCGGCTGATGTTTAGTGAACCCTCCGTCACGCACGGTGGGTACGGTGGGAGCCAGTTGAAGCGGTATACGCGGTTTACAGCTCCGGAGCGGAGGCGATCGTGGCAGCCCAGAGAAGACTCAACGCCCGCCTGCGTGAGGTCATCGAAGCGATCGGCTGCACCTACGACGCACTGGCGAGGGATATCCGGCGTATCGCAGCGGAGAACGGCGAGATCCTTCAGACCAACAAGTCAGCCGTCTCACACTGGGTGAACGGCACGCGCCAGCCGACCGGTCGCACTGACCAGTACCTCGCCGAGGCGCTCTCTCGCAGGGCAGGCCGCACCATCACCTTGGCCGAGATCGGCCTTCGCACACCCGAAAACACCGTGTCCGAGGAACCCGACCCTGTTCTGGCGGTGACCGACCTGGGCCGTGCCGACGTTGAACGCCAACGCTTCCTCGCCGTCGCTGCCTTCACCACCGCCGGTGTTTCCATGCCCCTCCTGTACGACCAAGAAGCCACCGCCCGCATGCTCAGAGCTCGCACCGGTGGCTCCCTGGTCGGGATCGAGGACGTGGATGTCGTACGGCAGATCACCGCAGCGTTCAGCAGCGCCGACGAGCGCCTCGGTGGCGGCCACGGCCTGACCACGGTCGCCGCCTACCTCGCAGACACGGCCGCCCCCATGCTCCGCGGGCGCTTCCCGAACGAAGCCCTACGGCAGGCTGCCTTCGGATCCGTCGCTGAACTCGCCTACCTCGCTGGGTGGAAGCACCACGATCTCGGCCAGGAAGGCGCTGCCCAGCGCTACTACCAGGTCGGCTATCAGCTCGCCTGCGAAGCCGACCCGCGAGGTCACGCCGCCTGGATGATGCGCGCCCTCGCCCATCAGGCGCTGAGTCTCAAGCAGCCCCACCACTGCGTCGACCTCGTCGAAGGAGCCCTCACCCGCTGCCTCGGTCACGTCGACGGCCAGACCGAAGCCCTCCTTCACATCACCCACGCCCGCGCCTACGCCGCGGTAGGAGAGAAGCCGGCAGCGGCCCGCGCGCTGCTCGCCGCCGAAGACGCTCTTCTGCGCGACGACGCGCCCCAGCCCAGTTACTCCCGCGTCAGCGGCCCTGCCGCCGGCACTGTCGCCAGCCACACCGCCCGCACGCTGACCGACCTTGCCGACCACGTGGGCACCGAGCAACAGCACCGCGATGCCCTGATGCGCTGGGACCCCGAGAAGTACAAGCGCGTCCACGCCCTCACCTACGCCGACCTCGGTGACAGCCTCGCGGCCCAGGCCCGCGCTGACGAGGCTGTCGCCGCCTGGTCTCAGGCCCTGACCCTCATGGAGGGCATGACGTCCGACCGCACCCGTAAAGCGATCACGTCGCTCCGCTCCACCCTCGCCATCTACCAGCGCCGCAAAGTGCCCGGAGCTGCCGAACTCAACCGCCGCGCACGCGAAGCACTGGCCTAAGCTGCCCACCAACCGGCCGACGAAGGGACACCAACCGTGGCTCAGCCGACAACCGACGACCAGCGCAAGGCCCTCAAGCCTGCTCTCGAATCCATGACTCTTCTGGTCGCCGCCGTCATCGTCCACGACAAGGCCACCAACCGCGTTGTCCTCCTCCAGCGCAGCGAGAACGCCAAGTTCGCCCAGGGCATGTGGGATCTCCCTGTCGGCAAGAGCGAACCTGGCGAGCCCATCACCGAGACGGCGGTGCGTGAGCTGTACGAGGAGACCGGGTTGACCGTGAAGCCGGAGACCCTGAAGGTTGCCCACATCATCCACGGCGCCTGGGGTGTGGAAGCTCCCAACGGCTTCCTCACAGTGGTATTCGCCGCCGATGAATGGACTGGTGAACCCGAAAACCGTGAACCGCGTAAGCACGCGCAGGTCTGCTGGGTCGATGCTGAAGCCATCCCCGAGGCGTTTGTCGATACCACGGCAAGCGCCCTCCGCCGGTACCTCACGGGCGGTTCGCAGGTGTCCCTTGACGGTTGGCGGTAGCCTCCCGAGACCGTTAAAACTGCCGTCGAGCCGGGGACTTTCGCGGAGCGCCTTCTCGCGCCCCGCGACGTGATCCGTGACTTCGAAGGTTGGACTGCCGCGGGGGTCAGCTTTCGGTCATTACCTGATCGCAGCACCTGGATGTGCGCCTTGTACTAGTTTGTGGTGTGGCGGCGTGCCTTCTGTCCGAAGATGATGCCCCTTTGTGTCTGCCACGAATTGCTGTCGTGGTTGAAGCAAGAGACACGGGGGGCAGCTTGTCGTACACGGAGCACCAGTCGGTGTTCTCAGGCCCCGCGGTGCCCGTGGGGGTCGCGGGTGATGCCCGGGAGGTGATCGGGCAGGGGGTCTACACCGAGAGCATCACACGCCAGCTGAGTGCTGCCGCGTTCGTCCGCCCTGACTGGCTGGCCACGTTTCGCGCAGTGCTGGCGCAACTGTGGGATCACCTGAAGGCCGCGGTGAAGAAGCGCCTGCGATGGCTGTTCCCTCCGAAGGAGGCCGAAAAGGCTGTTGGTGCGGAGCCTGCGCCCCCAGCGGTTGTGCTCGGTGAGGACTACGCCGTCTGGATCCGCCGTCGAATCAAGAATCCGGCACGGCCGGTACCGGTCTACGGCTTCCATCAGGAGCCGGTGGTGCACGCGTGTGATCGTGCGATTCAGCAAATGCGCAGACGCCGAGTGGCCATCGTGTCCTTGATCGCGGTCGTTGTCTGGCAGGCCATAGCTGGCCTTCTCACGGTGGGCTGGGCAGCCCTAGTCCTGCTGACGGGAATATGGGGCGTCTACCTGGTGGAGCGTTACCTGGCACAGCTGCGGCTCAATGCTCTACTGGCCGGAGAACTGCGTGCGCCCCCGACGGCGGTACAGGCCCATGCCCTGCCGTACTTCTACGAACGTCGCCCCAACGGTGACCGGCACCGGTTTATCGGAGCAGGACTTCAGGCATGGCAGGAAGCCGTCATTGGCATCGACGTCGAGCCCGCACCCGAGAGCCAGGACGACGAGGACGACAGCACGGGCTTGCTTCCCGGCATCAGCTCACCGACACAAAACCCAGGTCGTCCCGACATGGCCGAGGTGGCACAGGCAGTCCTTGACGCACTGGCAAGACACAACAAGCCGGTTGCGCGCAAGCCGATGAAGCACTTCACCGCCGCTCAGCTGCACGCCTATATCGCACGCCGCTTGGAAGACCCGGCTCCCTCCCACCACCGTGATCATCCGAAACTGCGCGTGGAGGTTGTCGGGATCGCAGGCATTCACTACAAGCGCTGGGACCAGATCGACGAGGACACCTGGCGCAGCCTGCACACCCTCGCCGTGGACACCGCTGGAACCAAGCCTGTCGAGGAGATAGCTCGCCGTTACGTCTGGGCGCGCATCACCGCCTGGAACGGCGACTTGATCGCCGCCATACTCGTCCGCTTCGCTTACCAGGGTGGCTTCCTGCGCGTCACCGTCCGTCCGCACATCATGGGCCCCCTCAACCCGAAGGTCGCCGGTCTCGGGCCCGCCGATCCACGCACGCCGAAGTGGCTAGGCCGCGCCGCATTCAACGCACTCGTCGACGCCTAGGTCGGTCTGGAGCGGCTCATACGTCGCAAGGCTCGTCCGCGCCCCGAACTCGACCCCGGCAGCGGGCCGGTCAGCCTCCGCGAGGTCTACAGCGTCCGACGGCTGGAGGACATGCACATGTACGACGACGCCCGTTACTACGTGCAGATGATGCAACGCCGGGTCTTCGACTCCACCGAGGTCTTTCTGCGAGACCACAACGTCGACATCGCCGCCTACCGCCAGCAGTCCACTGCGATCTACAACTTCGGCGTCATGAACGGCGGCACGATGAGCGGCCCGGTCCAGGCCGCACCGTTCTCGGCCAACCCCTCCACGACCAACTGACCCACAGGCCCGACAGGAGCCCCGCATGCCCATCCGCCGGCAGCCCGATCCCATCCCGAACGGCCCTAACTTCGGCATTGTCAACAACGGCCACATGAGCGGCCCCGCCCAAGCAGCGCCGTTCTCCCAGAACGCAACCCAGACCAACAACATCACTAACGAAGCCGTCGAGAGGGCCCGCGAAAGCATCGACGACCTGAGGCGACGCCTGGAAGAGCTGCGTGGACGGTACCCCGAGGTGGACGCTGCCCTGCGCGACCTCGGCATGATCGCCCCACGGCTGGACGAACCCGAACGCGATCCGGGCACTCTGCGGTACATGCTCCAGAATCTCGTCGAGCGATGCGGGGGTATACCCGGTGTCCTCGCTGCAGCCCAGCTCGTTCAGTCCACGGTCATGGCGCTCCTGCCGGGCTCTTGAGCCCCTCCACCACCCAGAAGGCATTCACCGACGCGAGCTGCCCCGTTTCGGCAACGCCAGGAAGAAACGCGGTGCCCAGATCGGTTCCAGCGCGGTGGCAGAGGTCCTCGCGGTCGGCGCAGCCGGAGTACCCGACATCGGCTTCGTCCGCGACAACGAGACCGCCGCTGCCTACATCGGCCCCCTCCTCCAACCCGGCGATGTCGTCCGTGAAGGCGCCCCGCGGCGGCCAGCCGCGGCAGATTGCCCAGGCCCGCACGGGACAGCCGGTTACTGGGCTGTGAGAACGCCCGTGCTCGATATGGCGGGGGCCTGCTCTGGTTCCCGGGCAGTCTCCACAGGTGGTGTACCCGCCCGTTCGCGTCGTGCCCTCAGCTCCCGGTGCTTGGCTGACGCCGGGGAAAGGCGTCCCCGCTCGGCCAGTGCTCGGGCAGAGCAAGAGACGTGTGGATGGGGCGAGCCGCTGGCTTGCGTTCGACGTGATTGTCAACCAATTGTGCCGTTTCCCAGGTGGGGAGAACGGGGGCCGGGAGCGAGCCACGGGTGGGGCTTTGCCAGAGAACGGGGACCTTCTTCGTCCAGGTCCAAGGTGCCGGGTTGTCGACAGTCAGTACGCCGCTGACCCGACTATGGGCCTGTTCCTGTGCAGCAGTCCAGTAGCCGTCGGGATTGCGGCCGAAGGTCGATCCGGTGCGGTGGGCGTATTCGACCGAAGTCCCGTACAGTGCGCTCTCGATATCCTCATCTTCCGGAAAGACGGCCGAATTGCCAACCGCCACGATGAATGGCAGCGCCAAGTCGCCGTACCTCCCACCCTTCTTTCTCACGGCTTTGAGCAGTCGTTTGGAGTCGTCAGCGACCCATACCGAGGGATGGAAGCCGATTGTCCTGCTCGCCGGATCGCCCCGCCTGCCGGGGCTGCGGGGGATCGCCTCGAAACTGAGGCGCCAGTCTGCCTCCTGCCAGGTGTGCCTGGGCAGCGGTACCTTCTGCTCATACTCGGCAGTGACCAGGTCGGGATCCAAGTTCGCCAGCCATCCTGTCAGTTCACTCTTCAGTCGCTTTTGCGGCGGTGTGGTCGAACCGATGCTGTCAACCTTGTATGACACGTAGAAGTTTGGGCTCGGAATGCGGTCGATGGCGTCCGCCACCTGAGGCGGGAGCGAGCTGCTCCCGGTGGCGTCCAGATGCTGGTTCGCCCAGATCGCCTCGACAATGAATTGCTCGTCGTCACGAGTCACCAAGAAGTCCGGGTTCTTCCCGCCTGTGCCTATTTGCTGCTCGATCTCTACCGTGCAACCGGAGCCGAGCAGCATCTCGTGCAGGTACAGCTCCCAAAACGCGGAGAAGACGTTCGCGTTGGAATTGCGGTCCCGTAGGCGACTGCGCAGGCTGGGCTGAGCATCGGGGGGAAAGTGCGACCACCACTCGTTGATCACATCCCGAACTTGGTCCCAGAACGGACCGGCGATCCGTTCGAAGAACTCGGCATCCGACTCCGATGCCCGCTTCGGTGCCGCATCTGTCCGATGTCGGCTTGTGTACACGCCCATGGCGAGCGATAGTAGATTGCTCCGCGTGGCGCTCTCACCTGATTTCTGCAGCGTCCCAGTGACCCTTGGGTTGACCACCAGGCCGACCGCAGAGATCCAGCCCAGCGGCGACAGCGGTCGCGGCTGCCCAGCGCCCCGGTCTGGCGCCGACCGCCCGGCGCCAAGTCGGAGCGAGTGCAGAGGTCAGCCCAGGTGTTCCTCCTGCTCGTTCCGCAAGGCGTCCCGCACGGAGCGCCAGGCACGGATTGCGTCACCGAAGTCCTCCAACAGCCCTCGTAGCTGGCGAATCAGAACCCGCGCAACACCAACTGCAGTAGCGACTTCGAATTCCATCGCGAGCCCCCTCATCGGCTGCTCCCCACCTCGGGCACCAGCCTCTCCGCCTCGCACCGCGGAGTCTGTACCCCGCTAAGGGCTGTCCCGTAAATGATCTTTGACGTGCCTGGTGACCTGCTTGTTTTCTCGTCACCCGGCGAGGGTGAGGTTGTACAGGCGGGCGATGCCGAGCATGGCGTGATGGACGCCGTCGCCTTTGAGGCGGCAGTCGCGGAGGATCTTCCAGGTCTTCATGCGGGCGAAGGCGTGCTCGACGCGGGCGCGGACCTTGCGGTGTGAGGCGTTGTGTTCCTCTTTCCATTCGGGGAGGTCGGCCTGGCCGGGCTGGCGGCGGTGCGGGATGACCAGGCCGGTGCCGCGGTAGCCGCCATCGGCGATGACGGTGGTGTGGCCGACGGCATCCTTGGTGCCGGACAGCTCCCACGCCTTGCAGTCGTTACGGTTGCCGGGCAGTGGTCGGCCGACAGCGACGACGAGCCGGGTGTCGGCGTCGATGACGACCTGGTGGTTGGTGGAGTACCGGTAGTTCTTCGACTGCTCGGCCACCTGGTGGTCGCGGGTGGGGACCAGGGTGCCGTCCACGATGAGCATGGTGTCCTTGCGGAACCGCTTGCGCTGCTGCAGCGCGAGCGCCGGGCCGAGGTGGTCGATGATGCGGTCCGCGGCCGACTTCGACACCCCGAACAGCGGCGCCAGTTGGCGCAGGGTGAGGTTCGTGCGCCAGTACGCGGCGACCAGCAGGACCCGGTCCTCCAGCGGCAGGCTCCACGGCCGGCCCTTGCGGACCGGATCCGCACCCTCCCGCCGCAGCGCGGTGACCAGCTTGCCGAACTGCCGCGGGCTCAGCCCGGTGAACGGGGCTATCCAGGAAGGCTCCGACGCCGTGATCACACCAGACACGGCAAGATCATCTCACCTGTGACCAGCAGTTACGGGACAGCCCTTACTGAGTTTTTCGTAAGTTCGGTGGGTGTAGTGGCCGTGTGGGTGGGAGGCTGTCGGGGTGGCATATCAACCTTCCCCTTCGGTTGCCGGCTCCTGCCTTCCTCCCTTGTCACGGCCTCAGTTGGCGGAGGCGCGTCGTGTTCGGGCAGTCGAGCTGTTCGAGGGCGGCGTCTCGAATGCGGAGATCGCGGGGGCGGTGGGGGTGTGTGCCGAGAGTGTGCGGCGTTGGCGGCGGGTGTGGGAGCAAGACGGTGCTTCGGGCCTGCGGAGACGGGCAGCCACGGGACGCCCACCCAAGCTGGACGACACCCAGGTCGAAATCGTCCGGGCCGCGTTGGAGCAAGGTGCCCAGGCTCATGGTTTCGAGGCCGACCTGTGGACCCTGGAACGAGTCGGCGCGGTCGTTACCCGGGCAACGGGGGTGGTGTTGTCGAGGGCGTCGGTGTGGCGGCTGCTGACCGGCCGGCTCGGATGGAGCCTGCAACGGCCCGAGCGGCGGGCGGTCGAGCGGAACGAGTCCGAGATCGCCCGCTGGATCGCACACGAATGGCCGCGCATCAAAAAGGGGCCGTGAACACACGTGCCTGGATCGTCTTCCTCGACGAATCAGGCGTCTCCCTGCTCCCTCAGATCCGCCGCACCTACTCGCCCCGAGGGCGGACTCCGCTCCTGCGGCACCGCCTGAACTGGAAGCGTGCGTCGATGGCCGGAGCCTTGGGCTACCACTCCACCGACCCCGATCGCGGGGCACGCCTGTGCTTCCACCTCAAGCCCGGCAGCTACGACACCGCCACCCTGATCGAGGTCCTGGAGCAGGTGAAGGTGTTCTACCGCGGCGAGCGAGTGGTCCTGGTCTGGGACGGCCTGTCCGCCCACTGGAGCCGGGCGATGCGGGCCTGGGTCGCCGAACAGGACTGGCTCACCCTGGAACGATTACCCGCCTACGCTCCCGAGCTGAACCCGGTGGAACTGCTGTGGTCCTCGCTCAAGAAGCGTGAACTCGCCAACCTCGCTGGCGACCACCTCGCCGATGTCGCCGACGCCACCGAGCAAGGCATCCACCGCATCAACGCCAACCCCCGACTGCCATGGTCATTCCTCGCCCATACCGGCCTGACCATCCGCCCACCACACCCACCGAACTTACGAAAAAATCAGTAGGTACATTTCGCGATCACCCTCGGCTTCACCCACGCGATCAGACGGACACGCGGCTGACCCCAACGAGCCGAGCCTCTTTGAGGCACCGCGTACAGGAGTCGCCGCCGTGAACGCGCGGGTCAGCATCAGAGTTGAGGCATTTGCTGATCTTGAAGGTTCGCACCACGGGAACGAGGCCGAGCCGACGCCCCCAGGGTGCCCGGCGAGCGGGCCGGCGTCTGTAGGGTCGAGCCTATATTTTGTGATCTTGGATGGATCTGCATGCGTGACCCATCCGGGGATGTTCTGCGCAGGTCATTCGAGGTGTCCTGCGTGAGCGATGCGTGAGCGGACGGTCCGGCAGGAGCTGTCACACACCGAACCCCGACGCACGCTGAACTCTCCCTGACCAGGCGGTTCCGGACGCCGAGGCAGCGTCCGCAACCACTCGTCATGCTTTGGTCAAGACTTTTAATCCATTGGTTGTGGGTTCGAGTCCCACAGGGCCTACGGCTGCGGGGGAGGGGTTACCCCCTCTGGCCTGCCACGCAGCGCCCGGGTCGACTTCGGTCGGCCCGGGCGCTGCGGCGTTTTCGGGTCCTGCGGGAGCCGGACCCGATGAGTGCGGTGCCCTTGTCCGCGTATCGGGCGCGGACTGCTGACCGGCGCCGATCGCACGGACCCGCCCGCCGGACTGCTCGCTCGCTCCACATCACCCGCCCCGTCAGACCGTCAGTTCCGGCAGCTCCGTCAGTGGCAGGGTGTGCTGGGTGTGGAGGACCTTCGCGCGCAGGTAGCGGACGTTGTGGTCCGTGGGGAAGACGCCGGTCGGCACCCGGTCCCGCACGGCGACGCCCAGGGCGCGCAACTGTCCCGCGTTGTCGGGGTTGTTGGACAGCAGGTCCAGCTCGCTGACGCCGAGGGCGGTGAGCATCTGCGCGGCGGCCCTCGCGCGGCCGGGCGCCGCAGTCGCAGCGGGCCGAGCCGAAGGCGTCGCCGGTCACCTAGTCGGCGCAAGGCGACGACCGTCGGCGCCACGGCACGTCCTCCGCCGCGGTGGCGCCGCCGTCCTCCCCCTGGAGGCCGCGTGCGATCCCCGCGCAGATCTCCTCCAGTTGCCCCACCTGCTCCGGGGTCAGCCGGTCGAACAGGGTGGTGCGCACCGTCTCGACGTGGCCGGGCGCCGTACGCTCCAGTACGGCCGTCCCTTCGTCCGTGAGCACCGCGAGCGAGCTGCGCCGGTCCCGGCCGGAGCTCTCCCGGCGCACCAGGCCGTCCCGCTCCAGCCGGGTCACCACGTACGTCAGCCGGCTTCGCGTGATCTTCAGCGTCTCGGCGAGATCGGTCATGCGCAGTCGCCGGCCGGGGGCCTCGGAGAGGTTGGCCAGCACGGAGTAGAACAGGTGCGGCATGCTCCCCTCCTGCTGGAGCTGGCGGTCGATCGCGTCCTCCAGCAGCCGGGACGCGGCGAGGTAGGCGCGCCAGGCGCGCTGCTCCGGCGGAGTGAGCCAGCGGGTCGTCATGCCGCCAGTGTAGATTTGTTCCAAATTTGAACCAAGACTTCGGCCGGTCCACCGGGCCGCCGCGAGGGAGTACGCCGATGCCCCTGCCGTACGTACTGCTGTCCGCCGCCGTCTCCCTCGACGGCTTTCTGGACGACACCGGCCCTGAGCGGCTCCTGCTGTCCGGCCCGGCCGACTTCGACCGGGTCGACGCGGTACGGGCCTCCGTCGACGCCATCCTGATCGGCGCCGGCACGATCCGCGCCGACAATCCGCGCCTGCTGGTCAACTCCGCCGAGCGGCGTGCGGCCCGGGTGGCGGCGGGCCGGCCGGCGTACCCGCTGAAGGTGACCGTCACCGCCTCCGGGGACCTCGACCCCGGCGCCCACTTCTGGCACACCGGCGGCGACAAGCTCGTCTGCACCACCGATGCCGGTGCCGCCCGGGCCGCCCGGCTCCTCGGCGGCACCGCCGACGTCGTCGCGCTCGGCCCCGCGCTGGACTGGCGGGTCCTGCTGGAGCATCTGCACGACGTGCGGGGCGTCGGGCGCCTGATGGTCGAGGGCGGAGGGCAGGTCCACACCCAGTTGCTCCAGCAGGACCTCGCCGACGAACTCCAGCTCGTCCTCGCCCCGCTCCTCGTCGGCGACCCCGCGGCCCCGCGCCTGTTCGGCCCCGGCGCCTACCAGGGCGGACGCCTGCGCCTGACCGACACCCGCCGCATCGAGGACGTCGTCCTCATGCGCTACGAGCCCACGGCCCCCGGCACCGGCCCGGTCGCCACGCCCGCCGACCGGCACTGGCTGCGCACCGCCTGCGAACTCGCCGCGCTCTGCCCGCCCTCCCAGACGGCGTTCAGCGTCGGCGCGGTCCTGGTCGCCGCCGACGGTACGGAGCTGGCCCGCGGCCACTCCCGTGAAGGCGCCGACCCGGTGGTCCACGCGGAGGAGGCGGCCCTCGCGAAGACCGACCCGGCCGACCCGCGCCTGCCCGGCGCCACGGTCTACAGCAGCCTCGAACCCTGCGCCCGCCGGGCCTCCCGGCCCGCCCCCTGTGCCGAGCTGATCCTGCGGGCCGGGGTGCGCCGGGTGGTCACGGCGTGGCGGGAGCCCGACACGTTCGTCGCGGCGGCCGACGGCACGGGCGTCCTGACCGGCGCGGGCGCCCGGGTCGTCGTACTCCCGGAGCTGGAATCCCTCGCCAAGGCGCCGAACGCGCATCTGCTCGCCTGACAGCACTCAGGGCCGGAATCCATTGGATTCCGGCCCTGAGTCTTCAGTAGCGGGGACAGGATTTGAACCTGCGACCTCTGGGTTATGAGCCCAGCGAGCTACCGAGCTGCTCCACCCCGCGTCGTTGTGTCTCTACTGTACGCCATCCACGGGGTGCGATGCACATCGGTTCCCCGGCCCCCGGCGACCGTCACCGACAGTGAGTGGGTGGGCGCCGTGCGGCAACGGCTGAGTCACCATCAAAGACGCGAATGACTCCTGTACGTCGGTCAACTCGTCCGGTTTGCAGGAGTCATGGCTGGTAAGTCCCCGGGTGTGAACATTAATGATCAAGACGGACGGCTTGGAAAGTGACTGGCAGGTCTATTAACGTTCGATAACGCAGCGCGGTCGTCCCAGCCGTCACCAGCGACGGCTCCGTGCGCACGCGCCGAATCCCGCAAGGGAACCGGGGAACCACCACCCTGGGGTGAATCTCGCGAACGCCGACGTGGAACTCATGGAGTCCACGACCGGTATACGCGCGTAGGAGACCTTCCTGCTCCGAACCCGTCAGCTAACCCGGTAGGCGGCGGAAGGAAAGGAGCACGCCCGCGTGGCGTCCAACCGGCCTGCCCCAGAAACCCCGTTCGTGCCGGCTCAGCGCGAGACCGAGACCTTCGGCTACGACGCCCACCGAGCCGACGAGGGCCCCTGGGAGGAGTGGAACCCCACCGAGGACTCCGTCGCCCCGGTCCGCGGCCGGCACCGCGTCGCCAAGCAGCGCGGCGGCTTCGCGCGCAGCTCCACCGTCCTCGGCGTCGGCGTGATCGCCGCGGTCGGCGCGGGCGGCATGGCCAGCGCCAACACCGGCAAGCCGCCGGTCTCCATCTCCCTGCCGGACCTGCCCTCCGTCGGCTCCCTCTTCGGCGACACCTCCACCGAGGCGCCCAGGACCGCCACGACCGCGCTGAGCAGCGTCGGCGTGGCCTCCGCCGACGACCAGCAGGGCACCGACGCGGGCGAGGCCCTGCGCAACCGGATCCTGGCCCAGGCCGAGCAGCAGCAGGGCCAGGCCGACAGCAGGGCCACCGCCGTCGCGCTCGCCACCGCCGAGAGGCAGAGCGCGCAGGCCGCCGCCCACGCCGAGGAGGAGGCCGCCGCGAAGGCGGCCGAGGCCAAGGACGCGGCGGAGGCCGCCGCCGCGAAGAAGGCGGAGCGGAAGGCCGCGAAGGAGGCCGAGGAGAAGCGGCAGGCCGAGCTGGCGAAACTGGCCGGGCAGTACACGCTGCCCACCTCCTCGTACACGATCACCTCGACGTTCGGCCAGGCCGGCACCATGTGGTCCTCCGGCCACCACACCGGCCTCGACTTCGCCGCCCCCACCGGCACCCTCATCAAGGCCGTCCACGGCGGCACGGTCACCGAGGCGGGCTGGGCCGGCGCCTACGGCTACCGCACGATCCTCACCCTCGACGACGGCACCGAGCTGTGGTTCTGCCACCAGTCCTCGATCAACGTCACGGCCGGTCAGAAGGTCACCACCGGCGAGGTCATCGGCCGTGTCGGCGCCACCGGCAACGTCACCGGCCCGCACCTGCATCTGGAGGTCCACCCCGGCGGCCAAGCAACCGGCATCGACCCGATGACGTGGCTGCGGGACAAGGGCCTCACCCCCTGAACGCCCCCTGAACGGGTGTTCGCCGGAACTCGGCGCCGGTGGCGGGGATGTGATCACCCGCCGTCGGCGTTGTAGTGACGTATGACCTCAACCACATCACCCCGCACTCTCGGCTCCTCCGATCTCCAGGTCTTCCCGCTCGCCCTGGGCGGCAACGTCTTCGGCTGGACCGCCGACGAACAGACCTCCTTCGCCGTCCTCGACGCCTACACGGCCGCCGGCGGCAACTTCATCGACACCGCCGACTCCTACTCCGCCTGGATCGAGGGCAACCAGGGTGGCGAGTCGGAGACGATCATCGGCAAGTGGGTCAAGGCCCGCGGCAACCGCGACGACGTCGTCATCGCCACCAAGGTCAGCCAGCACCCCGAGTACCAGGGCCTGTCCGCGGCCAACATCAAGGCCGCGGCCGACGCCTCGCTGCGCCGCCTGGACACCGACCACATCGACCTCTACTACACCCACTTCGACCAGCCCGAGGTGCCGGTCGAGGAGATCATCGGCGCGCTGGACGAGCTGGTGAGGGCCGGCAAGGTGCGGCACATCGCCGCCTCCAACATCAGCCCCGAGCGCCTGCGGGCCTCCCTCGACCATTCCGACCGCGAGGGCCTGGCCCGCTACGTCGCCCTCCAGCCCCACTACAACCTGGTCTCCCGCGACACGTACGAGGGCCCGCTCCAGGACCTCGCCGCCCGCGAGAACCTCGCCGCCGTCCCGTACTTCTCCCTCGCCGCGGGCTTCCTCACCGGCAAGTACCGCCCCGGCACGACCGTCGACAGCGCCCGCGCCGGTACGGCCCAGAAGTACGCGGACTCCGAGCGCGGCCGGCGGGTCCTTGCGGCCCTGGACGACATCGCCGCCGCCCACGAGGCCCCGGTCGCCACGGTCGCCCTGGCCTGGCTCGCCGCCCAGCCGACCGTCACGGCCCCGATCGCCTCGGCACGCACGGTGGAACAGCTCCCGGCGCTGCTGGGCGTGGCGGACCTGAAGCTCACGGACGACGAGCTGGCAACCCTGACCACGGCCTCCGCGTAGCCCCCGGCCGGGGCGGCCCACGACCCGCGTGTCCTCCCCGGCCGTCCTGTCCGGCTACGACCGGTACGGGTTGTACGCGGGGTAGGCGCCCGCCGGGGCGCCCTGCCAGTACGGCATGGGACCCGCGTACACCGGCCGGGGCGGCGTGGCGGCCCGTGCCGCGTACTCCAGTGCCGGGCGTGCCGGTTGCCTGCGTCGCCACAGCTCGTCCAGCAGTTCCCGCTCCCGTACGACGAAGTCGGCCCCGGCCCGCCCGCGCCGCCCCCGGTGCCGCAGGAACGCCAGCGAGGTCGCGCACGCCTCGTAGCGCGCCACCTCCCGCGCCGCCGGGCGGCCGAAGTGGTGCCGGGCGTAGTCCCGGGCCATCCGCCGTGCCCGCATCGACCCGAGCGCGAACGGCTCGGCCGGGCCCAGCCATCCGGCCAGCACGTACGCGGGGAGTTCCGCGCGCACCGTCCGCAGCTCCCGCTGCCGCGTCCAGATCGCGAGCCAGGTCAGCAGCGCGAACGCGGGCAGCATGAAGGCGGCGTAGACGGCGAAGAACCCGTACTCGCCGAACGTGGAGGAGCCGTTCCAGAAGGCGTGCATGCTCATCGCGAGCAGCAGTCCGCAGACCGGCAGGAGGACCCGCCGCACGTGCTGCCGCTCGCCGGACAGCGCGGCGACGCCGAAGCCGATGCCGGTCAGGACCGTGAAGAGGGGGTGCGCGAACGGCGACATCACGATGCGCACGAAGAAGGTCGCGGCGGTGACGGAGGCGATGCCGCGGTCGCCGGTGAGCTGGTCGGTCCCGAAGGCCGTACCGAGGTAGAGGATGTTCTCGGTGAACGCGAACCCGGTGGCGGTGATCCCCGCTATCACCACGCCGTCCACGATCCCGGTGAAGTCGCGTCTGCGGAACAGGAAGACCAGCAGGACGGCCGCTGCCTTCGCGGACTCCTCCACGATCGGCGCTATCACGGTCGCCCCGAGGGTGTCGGCGCCGGCCGGGTCCGCGGTCGAGGTGGCGATCCACCGGGTGGCGAAGCTGTTGGCGACGATCGCTATCAGCGCCGCCGCGCACGCCCCCCAGGCGAAGGCGAAGACCAGGTTCCGCCGGGGTCCCGGCTCCACCCGGTCCAGCCACCGGAACGCGGCTGTCAGCCAGGGCACGGGCAGCACGGCCAGCCCGAGCCCGACGACGAAGCCCTCCGTGCCGGTCTGCCGCCGCACGAGCGCGAGGATGACCAGGCCCGACAGCGCCAGCAGGGTGCTCAGCGCCCCGTACCGCACCCACGTGCGCTGCCACCAGTGCGGATGGCGGAGGGCACCGCCGACGGGGCTCGGGGGGTAGGTCGGAAACGCAGGACTGGTGGCCACGGCATCGACCCTAACGGTGACGGGACGAGGGGCAGGAGCGGATTATCGGCCCGGGCGCGGGGCCGGGCTCATCGCCCCCGGTGCGGTACGCGCCGGAACAGCAGGTCGTTCACCACATGACCCTTGTCCAGTCCCTGTCCCTCGAAACGGGTCAGCGGCCGGAACGCGGGGCGTGCGGCGAATCCGCCCCCTGCCTGCGTGTTCTCGAAGTCGGGGTGCGCGTCGAGCACCTCGAGCATCTGTTCGGCGTACGGCTCCCAGTCGGTCGCGCAGTGCACGACGGCGCCGGGCTTCAGCCGGGTCGCGGCCAGGGTCAGGAACTCGGGCTGGATGAGGCGCCGCTTGTGGTGCCGCTTCTTGGGCCAGGGGTCGGGGAAGTAGACGCGCAGCCCGTCCAGCGCGTCGGGGCGCAGCATCTCCCGGAGCAGGATGATCGCGTCGCCGTTGCCCACCCGGACGTTGGACAGTCCGTCGCGGTCCGCGAGATTGAGCAGGTTGCCCTGCCCCGGGGTGTGCACGTCCACGGCCAGGATGTTGGTGTCCGGGTCGGCCGCGGCCATCCGCGCGGTCGCCTCGCCCATCCCGAACCCGATCTCCAGGACCACGGGACGGTCGTTCCCGAACAGCTCGCCGAGGTCGATCACCCGCTGCCCGTCGATGTCCAGCCCCCATGTGGCCCACAGCCGCTGGAGGGCGTCGGCCTGCCCGGCCGTCACCCGGCTGCGCCGCGGCTGGAAACTCCGGATCCGCCGTTCGAAGTGCGATCCGGCGGGATCGGCCCTGGGCCCGTCCGGGAACCGCGGCTCACCCCGGGTCCGGGTGTGCCGGACGGAGACACCGGGGTCGTGCGGTGCCGAGAGCGGGGCGTCGGGGGTGTTCAGGGAGTCAGCCACAGTACGACCGATTTTACGGCGCCCCACGAGGCCGCCCTCCTGCACGAGCCCGGCCGTCCCCGTGCCCGGACCCACCCGAGCGGAGCCAGTGCCCGGCTTCCCCCCCCGTGGGCGGTCCAGCGCCCGGCCCTACGCGAGCAGGTCCAGTGCCCGGCGTCCGACCTCCCTGCCGATCGGCAGGGACGCGGTGGCCGCGGGGGACGGCGCGTTGAGCACATGCACGGTCCGCGCACCCTCCTTGATGAGGAAGTCGTCCACCAGCGTCCCGTCCCGCAGCACCGCCTGTGCCCGCACCCCGGCGGCGGCCCGCACCAGATCGCCGGCCTCCACCGCGGGCAGCAGTCTTCGCACGGCCTCCAGGAACGCTCTCCTGGACACCGACCGCCGCAGCTCACCCGCCCCGTACCGCCAGTGCCGCCGGGCGATCGCCCACGACCCCGGCCACGCGAGTGTCCCGGCCAGCTCCCGGGGCCGTACGACCCCCCAGCCGTACCCCTCGCGGGCCAGCGCCGGCACCGCGTTCGGCCCGATGTGCACACTCCCGTCGATCCCGCGCGTCAGATGCACTCCGAGGAACGGGAACGCCGGATCCGGCACCGGATACACCAGCCCCCGCACCAGCTCCGGCCGCGCCAGCTCGTAGTACTCCCCGCGGAACGGCACGATCCGCACCTCGGGCTCGTCCCCGGTGAGGCGGGCCACCTCGTCGCAGTACAGCCCGGCGCAGTTCACCAGCACGCGCGCGCGGACCACGTCCCCGGCCGCGGTGAGCACGGCCACGCCGCGCTCCGGCCGCCGGTCCACCCGGACGACCCTCGCGCCGTACCGGATCTCCGCCCCGGACGCCCGCGCCAGTTCGCGCGCGACGCCGACGAAGTCGCACACCCCGGTCGTTCCCACGTGTATCGCGGCGAGACCGCGCACCTCCGGCTCGTACTCGCTGATCTGCGCGGGCCCCAGTTCGCGCACCGGGATGCCGTTCTCGCGGCCCCGCTGCACCAGCGCGTGGAGCCGCGGCAGCTCCTCCCGTCCGGTCGCCACGATCAGCTTGCCGGTGACGGCGTGCGCGATGCCGTACTCGGCGCAGAACTTCACCATCTCCGCGGCGCCCCGCACCGCGTACCGCGCCTTGAGGGAGCCCGGGCGGTAGTAGATCCCGCTGTGGATGACGCCGCTGTTGCGTCCGGTCTGGTGCCGCGCCGGGCCGGGCTCCTTCTCCAGCACCGTGACGCGCGTACCCGGTGCGGCGCGCGTGATCGCGTACGCCGTCGACAGCCCGACGATCCCGCCACCGATCACGAGCACATCACAGTCGTACGCCCCGGCCCGCACCTGCACCACCTCCGCCCTCGATAGTGCACTGCGCCACTGACAGTGGCTTCAAACGCCGACCGGTGACAGCGCCCCCGGAGCGGCACCGGCAGCGGACGCCGCGGCGCCGCTACGCCGGCGTCACCAGCAGCGGCCGGGCCCGCTCCCGCAGCTCCACCACCCGCGGCTCGTCCCCGTACGGCTCCAGGCGGTGCAGCAGGTCCTTCACGTACTCGGTGGTGCGGGCGGAAGAGATCCGTCCGGCCACCTCCACGGCCCGCACCCCCTGCTCACAGGCCGCGTCAAGGTTCCCCGACTCCAGTTCGGCCACCGCCGAGACGACGAGCCGCAGCCCGTGCGAGCGCACGAACTCCTCCGTCGGCTTCGAGAGCGCCTGCTCGGTGAACCGCCGCACCTGCCGCGGCGCCTTCAGGTCGCGGTAGCACTCGGCGGCATCAGCGGCGAACCGGTCGTAACCGTAGAAACCGAGCCAGGAGGGGTCGTTGTCGCCCTCCCTGGACCGCTCCAGCCACCCCTCGGCGGCCTTCAGTGCGGCGCCCGCCGCCTGCGCGTCCCCCGCGCGCGCGTGGGCCCGTGCCTCGATCAGCCGGAAGAAGCTCATGGTGCGGGCGGTCGCCAGTCCCCGGTTGCGCTCCAGGGCCGCCTGCGCGAGATCCACGCCCTCGTCGCCGAAGCCCCGGTAGGTGGCCTGCAACGACATGGAGGCGAGGACGTACCCGCCCAGGGGGACGTCGGCCGCCGCGCGCGCGAGGCGCAGCGCCTGGATGTAGTACCGCTGGGCGGCCTCCTGCTGGCCGGTGTCGAAGGCCATCCAGCCGGCGAGCCGGGTGAGTTCGGCGGAGGCGCCGAACAGGGCGCGGCCGACCTCGTCGGAGTAGGAGCCGAGCAGCAGCGGTGCCGCCTCCACCCGCAGGCACTCCGGCACCATGGACGAACGCCAGTCGCCGCCTCCGTATTTGGAGTCCCAGCGCCTGGCGTCCTCCGCGGCTTCCCGCAGCTTCTGTACATCGCTGTGGCCGACTTTGATCGGTGCGCCCGATTCCTCGGCGGAAGCCGTCTCGCGCGCGACCGAGCTGTCGGCGGGGGTTATCAGCCATCGTGAGGCGGGCGTCGCGTAGGCGCTGACCGCGAAGGACCCGGCGAGCGACTGCCAGATGCCGCCGGCGCCGGACCTACGGCCGGCGAGGTCGAGGCGGTACAGCTCCGTCGCCGACCTCACCGCCTGTGCCACGTCCCTGGGGAAGGCGAGGCCCACCTCGGGCGCGGGGTCCGCGTCGGCCAGGCCGATCTCGTGGAGCGGCACCGGGCGGCCGAGCTTCTGCCCGATGGCGGCGGCGATGAGGTGCGGTGCGGCACCCTGGGGCACCATGCCCTTCGACACCCAGCGCGCCACCGACGTCTTGTCGTAGCGAAGCGTCAACCCGCGCTGGGCGCCCAGGTCGTTGACGCGCCGCGCGAGTCCTGCGTTGCTGATTCCCGCGAGGGCGAGAACGGCGCCGAGTTTTTCGTTCGGCCCGCGTTGCTCCCTGGACATGCGCCACCCCTCGACACAGACGGCTGCCGCGATGGCATAACCGCGCGGCATTCGTAAACCCAGCGTAGTTCGCCGCATCCCAAGCGTTAAGGGGCATTCTTCCGGATGGCGGGATTGTGGTCCGTACGGCAGTACGGTCCTGTACGCACCGTGCACGGCCCGCCATCGCGTGCCCCCGCGCGTGTGGCCGTGCGCCCGTCCGTGCGCTCTTCTCCGGCCACCGGGGGAGCGGTTCCATGGCTTCTGCGTGGGTCGGCCCGCTGTACTGGATCCAGTGGGCTGGGGGACACCGCCGCCTTCATCCCCGCGGGTGGCGGACCGGTCCGGGAGGCGATGCCCGCCTCCCGGACTGTGCGTGCGCGCGCGCCGCCCGGCGCTCCGCAGGCCTGTACGGAGCGTGCTCATCTCCGTTGCCGCTGCGCGTAATTGGCCGAAAACCGCCCCCCTTTCCGGACCTCGAATTTCCGGTCCCACCACGCAACTTGAGGGCGTGAGGGGCGGTTTGGGGGCGCGTACTGGGGGCGCATTCGCGCCGCACCCGTCGGACACCGCCCGGAACCCGCTCCCCCCAGCCGCGCGGGCCACCGGCCAACTCCCCTGGCACGTGCCGCGAACTTCCCCCGGTCGAAGGCGGCGCCGCCGCCCCTCCCCGGCGCGTTCTTCATGGCAGCATGGGGACCCGGTTCGTACGGTGCACTGGTTGTCCACAGCGTGTGGAGGCGTCGATGCGGTGGTTGGTGGGGTGGAGCAGCACCGCCGCGGGCACCGCCGGGACCGGCACCGCGGGCGCCACCGGATACGACGGCGAGACCCTGCGCCCGGTCGGATCACAACTCCTGTGGGGCGACCCGGATCCGCTGTGGGCCGTCGGCGACTGGCGCCCGGACGAGGTCCGCGTGGTGCACGCCGACCCGCAGCACCGCATCGCCGTCCTCGGCATCTGCGGCGCCACCGACGAGGAACTGCGGCGCGGCCTGGTCACCGCGCGCGGGGGTGCCCTGCGCCATCTGACCAACTGGCCCGGCAGCTACACGGCCGTCGTCCAGGCCGGCCGCCGCATCACCGTCTGCGGCGACCTCGCGGGCGTCCGGCCCGTGTTCCACACGCCCTGGGCCGGCGGTACCGCCTACGCCACCGCCGCGCTGCCCCTCGCCGACCTCGTCGAGGCCAACCTCGACTTCACCCACCTCGCCGCGCTGCTCGCCGCCCCCGACGTACCGGCCGCGCTGCGCGACACCACCCCGTACGAGGGCGTACGGCGCATCCCGCCGGGACACGCCCTGGTGCTGCGCGCCGGAGCGCGCGAGATCGCCGGCTACGAGCCGGTCGCCTCCCTCGCCGTGGCCGCGCCCGCGTCCGACCCCGACCGCGCCGTGGACGCCGTGCGGGACGCCCTCGTGGACGCCGTCCGCACCCGGCTCTCCGCACCCCGGCACGTGCCCGACCTCGACCCCGGGCCGGTGCCCGGCATGGGACCCGCCGAGCGCCGGGCCGCGCGCGGGATGCCGGTGCCCGGCATCGGCGCCGACCTGTCCGGCGGCCCCGCCTCCGGCACCCTCGCGCTGCTCGCCGCCGGGCTGCCCGGCAGACCCGGCACGCTCCTCGGCCACGGCACGGGCGCGGGCGAGCGGCTCCTCGCCGTCACCTTCAACGACCTCGCCGTGGCCGGCCGCGAGGCCGAACTCCAGCGCGCCGGCGCCCTCGCCGCCAACCCCCGCCTGCACCACGTCGTGGTGACCGGCGGCGAGGAGACCCTGCCCTACGCCGGCCTCGACGGCCCCCTGACCGACGAACCCGGACCCTCCCTGGTGCTGGCCGCCCGGCACCGCGCCCGGCTCGCCGCCGGCAGCGCCGACCACTTCACCGGCCACGGTGCCCGCCAGGTCCTGGACGCCCACCCCGCCCGCCTCGCCGACCTCCTGATGGACCGCCGACGACGTCACCTGGTCCGGCCGGTCGCCGCGCTCGCCCGGGCCGACGGCTCGGTGCTGGTCCCCGCGCGCGTGTACGGCGCGGCCCGGCGGCTCGCCCGCACCCCCTACCGGGCGGGCCTGGAGGTGCTGGCCGAGCGGCTGATGCGGCGCCGCTTCGACGAGCCCAAGGGAGCGGTCGGCGCGTCGCTCGCCGCGCTGACCTGGGCCGGACCGGGGCCGGCCGCCCGCTGGCTGACGGGTGAGGCGCTGGCTGAAGTATCGGTTCTGCTCCAGGCGGAGGCCGACCGCTCCGGGACCGGCGCGCAGCGTCCCGGCGACTACCGCGCGCGTGCGGCGCTCGCCCGGCACGCCGCCGACCTCCGCGTACTGGAGCAGGCCGCGGAGATCCGCTCCCAGCGGCTGCACGCGCCGTTCCTCGACAACCAGGTCGTCCGCGCCTGCCGCGACCTGCCCGAAGCCCTGCGCGTCCAGCCCGGCGCACGGTCCGCCATCCTCCGTACGGTCCTGGCGGGCTCCGGCGTCACCGACCTCCCGCCCGGCTGGGGCACCCCCTCCCACGGCTCCTCGGCGGCAGCCGCGCGCGCGGGTCTCCGCGTCGCCGCCGACTCCCTCCTGGACCTCTTCTCCAGCCCCCTCCTGGCCGACGCCGGACTGATCGAGGCCCGCGTCGTCCGCAAGGCCCTGCGCACCGCCGCGGCGGGCGAGGCGCTGCCCCTCGACGGGCTGGCCGGCCTCGTCTCCCTCGAACTCTGGCTCCACCGCCTCCTCGGCCGCCGCGGCACCTGCTGGACGGGCACCCCCTCCCGCTCCCGAGCGGTCCCCTCGGGAATCCAGCCCAGACGGGGAGCGCTGACACCGGGGGCGTGAGGGTTCGTCGGGGCGCGGGGTGGCGTGTGGGGGGCGGGCATGCGCGCCGTGGCTGCGGGCAGTCGTGCCGCTGGGGCGGCACGGGTGGGCGCGGCGGCACCCCGCGAGCGCGGGTGAGCGGCCCGGCCCCCGGCCGGCGACAGCACCGGAGCCCCTGTCGGCGTGGGTGAACGGCTCGATCCGGCGGCACCGGAGACCCAGCCGAAGCGGGTCAGCAGCCCGGCCCCCGCCCGGTGGCAGCGCTCCGCCGGTCGCGAAACCCCCGTGCCCCGGCTGCCGTCTCCCGCGACAATGCCCTGGTGCGGTACAGAATTCTGGGCGTGACCCGAGCAGCGGACGACCAGGGCACCCCCCTGCCCATCGGCGGCCCACGCCTGCGTACGCTCCTCGCCGCCCTCGCCCTCCGCCCCGGCCGCACCACCACCCCCGACACCCTCATCGGCGAGATCTGGGCGGACGCCCCGCCCCAGGACGCCCCCGCCGCCCTCCAGGCACTCGTCGGCCGTCTCCGCCGTACCCTCGGCAGGCACGCCGTCACCTACGCGCCCGGCGGATACCGCCTGGAAGCGACCGAGGACGACGTGGACCTGCACGTCTTCGAGCGGCTCACCCGCGTCGGCACCCACGCCCTCACCGCCGGCGACCCGGCCACCGCCCACCGCACGCTCACCGAGGCCCTCGCCCTCTGGCACGGCCCGGCTCTCGCCGACCTGCCCGACCGCACCGCCGCCGCCCGCCCGGACGCCCTCCGTCTGGACGCGGCCCGTGCCCGCGCCGCCGCCGCGCTCGCCCTCGGCCGCGCCCAGGAGGCCGTACCGGAGCTGAGGGAACTGGCCACGGCGCACCCGTACGACGAACCCCTGCACGCCCTCCTGATCCGCGCTCTGCGGGACACGGGCCGTCCGGCCGACGCCCTCACCGCCTACGAGTCCGTCCGCCGCACCCTCGCCGACACCCTCGGCACCGATCCCGGCCCGGAACTCCGCTCCCTGCACACGGCGTTGCTGCAACAGGAGAACCCGGCGCGCTCAGTGGATCCGGCGCACCCGATGCCCCCCGCGCACCCGGCGCCTCCGGTGCACCCGGAGGTACCGCACCGCGCCCGGCCTCCCCGGCGCACCGGTAATCTCCGTCCCCGTCTGACGTCCTTCGTCGGGCGGGAACCGGAGCTGGAGGCCATTCGTTCGGATGTGCACAGGGCCCGCCTGGTCACGCTCACCGGACCGGGCGGCTCCGGGAAGACCCGTCTCGCCGAGGAGGCCGCCGCCGCGTTCCCCTCGGCCTGGCTGGCCGAACTGGCCCCGCTCGACCGGCCGGAGGCGGTGCCCGGCGCGGTGGTCAGCGCCCTCGGTATGCGCGAGACCGTGCTGCTGGGCAACGAACTGGCGACCCCGCAGGCCGACCCCACGGCGCTGCTGGTCGAGTACTGCGCCCCGCGCAGCCAACTGTTGATCCTCGACAACTGCGAGCACGTCATCGGCGCGGCGGCCACCCTCGCCGAGACCCTCCTCACCCACTGCCCCGGCCTCACGGTCCTCGCGACCAGCCGGGAACCCCTCGGCGTCCCGGGTGAGTCGGTGCGCCCGGTCGAGCCCCTCGTCCCGGAGCAGGCGCACCACCTCTTCGCCGAGCGCGCGAAGGCCGTCCGGCCCGACGCCGACACCGTCCTCGGCGACACCGCGGCCGTGACGGAGATCTGCCGCCGCCTGGACGGGCTGCCACTCGCGATCGAGCTGGCCGCCGCCCGGCTCAGGCTGCTGACCCCACGGCAGATCGCCGACCGGCTGGACGACCGCTTCCGCCTGCTCACCTCCGGCAGCCGTACGGTCCTGCCCCGCCAGCAGACCCTGCGCGCGGTCGTCGACTGGTCCTGGGACCTGCTGGACGAGCGGGAACGGACGGTCCTGCGCGAGGTTTCGGTGTTCGCCGGCGGCTGGGACCTCGCCGCGGCCGAGGCCGTGTGCACCGGCCCGGTGGCGGAGCTGCTCGGTGCGCTGGTCGACAAGTCCCTCGTCGTCGCCGCCCCGCACGACCCCGACGGCACCGCCTCCGGCATGCGCTACCGCATGCTGGAGACCATCCACGAGTACGCCACCGAGCGCGCCGCCGAGGTCCCCGGCCTGCGCGAAGCGGCCGAGCGACGCCACCGCGCGTGGGTGCGGGCCCTCGTGGAGGAGGCGGAGCCGCGACTGCGGTCGGCGGCCCAGTTGCCCTGGATCTCCCGTCTGGAGACCGAGCTGGACAACGTCCGCGCGGCCCTGGACCGCGCGGTGCGCGCGGGCGACGAGGCCGGGGCGGGCGCCGTCGTCCTGGCCATCGGCTGGTTCTGGTGGCTGCGCAACCACCGCCAGGAGGCCGTGAGGTGGGTACGGCTGGTGCTCCGCCTGGGCGTCGCCCTGGACGCCGTGTCCGCGGGCGCGCCGGACGGCGGCCTGATGGCGCTGGTCGAGTCGGCCGACCCGGTGGGCGCCTTCCTCGCCGCCCCAGACGGCGAGGCCGGGCATCCGCTGCACGAGCTGCGGACGGACCTGCGCATGCTCGACCTGTTCCTGACGTCCGACTCCAGAGCGGAGAACCTCACGGCCGACGACCGGGCCCCGGAGTACGTCGCGCGCGTGCGCGCCGCCTACGAGCCGGGGGGCCCGCGGGCGGCCCGGCTCCCGGGCCTCGTCTGGCCGCTGACCGCCCACTACCTGGGTGCCCCGGCCGACGTCCACCCGGACCTGACACAGGCCGTCGCCAACTGCCGCCGCCACGGCGGTGCCTGGGAGGTGGGCGTCGCCCTGATGTTCCGCACCCACGTGACCGTCGACTCGCCGGGCAACCTGGAGGGCGTCGACGAGGACCTGGCCGAGCTGCGGCAGCTTAGCCGGCGCGTCGGCGACCGCTGGATGCGGGCCCAGGTGTGCGGCGCGGCCGGCGAGGCGGCGATGGCCCGCGGCCGGTTCGACGCGGCACGCGCCGAGTACGAGGAGGCACTGCGGCTCGCCTACGAGGTCGGCGCGTACGCGGAGTCCCCGTTCCTGTTGGCCCGCCTCGCCGAGATCTCCTACCGCTCCGGCGACCGGAAGGCCGCGCTCGCCGCCCTGGACGAGGCGGAAACGGCCGCCGACCGGTACGTGGTGCCGGAGTCACGCGCCTTCGTCATGCTGCTGCGCGCCCACATCGCCCTGCAGGACGGCTGCGCCGCCCGCGCCCGCGAGCTGTACGAGGCGACCTGCGCGGTCGTGCGGGGGAGCACCCGTCCTCCGCAGTTCGTGGCGGCCCAGCGCACGGTCGAGGCGCTGCTCACGGCCGACGAGTCCGGTCCGGCACACGGCCTGCCGATCGTGGCGCAGGCCCTGCGCGAGGCCGTGGAGCAGGGGGGTGCCGAGTCGATCACGGCGGGGCTGGTGGACATCGCCGCCGGCCTGCTGGCCCGGCTCGGTGATCTGCCGAGCGCCCTCCGGCTGTTCGCCGCCGCGGACCACTGGCGGGACGGCCGCCCGCGGCCCGAGCCCGAGCGCGGCGTCGCCGCCCGGGTGCGCGCCGGTGCCCGCGCGGCCCTCCCGGCCGACCGTTACGCGGCCGAGAGCGCCCGGGGCGCGTCCCTCGGCGTCGCGGACGTCCTGCGGGAGCTGGGCGTCCCGGCGGCCGTCGAGTGACGCCCGGTGTGTCCGGCCCGGCACGGCCTAGCGGCAGGTGAACCGGGACTTTGCCCAGTCCGCGAGCGCCGCCCGGTCGAAGGCGGTGCGGTACGGCTCCACCACGAGCCGTACGGTCCCGCGGCCGGTCAGGTCCACATGGACGGGGGCGGCCGGGTCGCGGCCCCCGACCAGGGGGGACCGCCAGAGCCGGACCCCGTCGGCGTACACGGAGAACGAGACCCTGCCCAGGCCGAGGGTGAGGTCGTCGACGCCGGCCAGTGCGTCGTAGGCGGTGCACCGGCGGTTGAGGGCGATGGTGACGGAGGACCGGCCGGACACGGTCACCCCGTGCGCGTACCGGCCGCCGCCGACCGACATGCCGTACCGCTGCCACACCCAGCCGCTGCCGCCCAGGGAGATCTCCGGCCGGGTGCCGTCGCCGTCGAGGTCGTAGCGCAGCTCGCTCAGCCGGTAGACGGCGGCCACCGGCGGTGGGGGTGGGCGCCGGGACGGGCGTCCGGGGCGGGGTGGGCGCGGGCTTCGGCGCGGGGGTGGGCGTCGGTTCGGGGGTGGGGGTGCGGCTGGGGGCCGGGGACGGAGGCGGTGACGGGGATGCGGGCGCGGTGGGTGCCGGCGCCGTCGGCTCCGGGGTGAGGGCGACCGGTTGGGGCATCGGCTTCTTCTTCTTCTCCGGCCGCCCCGGACGCGTCAGCCTCGTCGGCGGTGCCGGCTGTGCCGGCGGCGTGGGCGTCGGAGCCTGCGACCGCACGATCGGCGTGGGCGGCCGCGGCCGGGCGGCCTCCTTCGCCGGACGACCGTCGTTCACCAGGGCCAGCGCCACCGCCGCGACGGCCACCGCGACGACACCGGCCGCGATGCCCGCTTTCACCGGCGCCCCGAGCCCCTCCGAGGCCGCGGCCCCGCCGCCCGCCCCGCCGGACGACCCGGTGGCCGCGGTGGCGCCGGCAGCCCCGGCCCCGGCGCTGCCGGCCACGATCCCGAGGGCCTTGGCGTACCCGACGGCCCCGAACCAGCCGATGACCGCGACCGGTACGACACCGGGGATACCGCCGGCCACCTCCTCGATCTGCGCCGCCGCCAGCCGGCACTTCGCGCACTCCGCCAGGTGCTTGCGCAGGCCCCGCTCGGCGCGGACACGCAGTTTGCGGCGGGCGTACGTGCCGAGCTGGTCGGCGTAGCGGGCGCACTCCCCGTCCTGGGCGAGGGCGGCGCTGACGTGGGCCTGGAGGTAGGCCTGCTTCAGCCCTTCCCGGGCGCGGCTGGCGAGCACCCGGGTGCCGTTGGCGTCCAGGCCGAACAGCACGGCGACCTCGCTGGGGGACTCGTCCTCCACCTCGGTGTGCCACAGCACGGCCTGCCAGCGTTCGGGCAGCGACCGGAAGGCCCGCATGGCCATGGACTGCTCGGCCTCGTGCAGGGCGCGCACGTCGGCGCCGACCGCGGCGGTACCGGCGTCGGGTAACTCTGTCTTCAGTGCGGCCTGTTGGGCGAAGACGGCGAAGTCTTCGACGAGCTGCTCGCGCCGGGCGGACCGGCTCCAGTGCGCGGCGACATGCCGCACGGAGGTCAGCAGGTAGGCCCGTACGGCGTGTCGGGGGCCCGACCCGCCCCGCACCGCTTGCAGCATCCGCGCGAACACCTCGGCGGTGAGGTCGTCGGCGGTGTGCCCGTCCCGGCAGCAGCCGCGCGCGTACCGCCGCACCGCGTCCGCGTGCCGCCGGTACAGCTCTTCGTAGGCCGAGTCGTCACCGGCGCGCATCCGCCCGATCAGCTCGCCGTCGGCGGGGGGTGTCTCCCGGGGCGGCGGCAGGACGCTCCCCTCGCGCTGGGCCGGCACGCTCTCGCCACCCGGGCCGCCGACGGCAGCGGGGCGCCCGCCCTGGTGGGGCACGTGGGGTGAGGTCAGCCCGTGGGCTTCCGTCTCCCCGTCGTCACCGCGTGACTCGCCCCACCCGTCAACGCCCATCACGGAAAGCCCCCGACACCGGCCCAGCCCAACCCGACACCGGCTCAGAGTGCCACAGCGCGTTCGCCCGGAGGGCCCGTCACAGAGCCCATCCACTCGTCCGAGCGGACTTCTCCCACCCCACTCGAACACCCCGGCCGGCGACGGCGCGCGACAGAGGTCACCCGCGACAGGGGACACCCGCGCCCGTACGACTGGGACAGCCGCACGGGCGCGGGTGGGAGACGGCATTCCGCCGACGGCAGGACCGAAGCCAGCGGCGGTCACACCGGCCGGGACCGGAGTCCCCGCCTACACCGGCCGGGACCGGAGTCCCTCCAGCAGGATGTCCAGCAGCCGCGCGGACGCCGCCGCCTGCTGTGCCGCGTCCGGCAGTGACGGGGCCGCCGTGGCGATCACCAACAGCACGTCGCCCACGGACACGTCCGCCCGCAGCTCACCCGCCGCGCGCGCCCGCTCCACGAGCTGCCCGACCACCTCGAGCAGTGCCCCGGCCCCGGTGTCGTCGGCCGTCAGCGAGACCTCGTCCGCCACCAGCCGCAGCTCACCACCGCCCGGCTGCACCCGCTGCTGGGGCATCCGGGTCTCCTCGGCCGAGGAGACCGAGGAGACCCGGGCGACCGCTTCGACCGGCGGGACGATCCCCACCGAGCCGGCCGGCCCACCTGACGCCTCCGACTCGTCCGGACCGGCGGAGCCGACCCGCAGCACCTGCGGCGGCAGCAGCCGTCCGGCCCCCGACGCCACGGACGTCCGCAGGAACCGCGACAGAGCCGACCACGGCTCGTCCTCCTGCCCGAGCGCGGTCCGCGCCTGCTCGGTCAGCCGTGCCGTCTCCTCCTGAGCGATCCGCCGGACCAGCACGTCCTTGCTCGGGAAGCGCCGGTACACCGTGCCGACCCCGACCCGCGCGCGTCGCGCCACGTCCTCCATCGGCGCGCCGTAACCCAGCTCGCCGAACACCTCACGCGCCGCACGCAGCACGTGTTCCAGATTGCGCTGTGCGTCCACCCGCAGCGGTGTCGTACGCGCCCCGTCCGCGCGTCCGTCGCCCATCGCCGCGGTCATCGATCCGCCACCGGGCGTGATGGTGGCCGTAGATGCCCAATGCTTGTCCTGAACATGCATGTGTTTCCCCCGGTAATGACGTCTCCCCCCGGAGACTCCCCGCCACTGAATGCGAAGTGCGCGGAAGTGGCATCGGTCCCGACCGGACCCGCCCGTCGCGGACCCGCTCGACCACAGTCCCTACACCCCGTCGACACACGAACATAGTTGAGAGGCAGTCAATTCAGAAGGGGCAGGTTCCGCACAGTGCGCCCCCCGATCGGAGTACGGAGCACGTACGCCCCGATTGCGCCCCTTCGTGCACTGTCGCCCGCCCCCGCTGACCTGCCCCGATTCGTCCTGCGGGGACACCGCGGCCGACCTTGGGCACACCAGGCCGCCGGTCACACAAATTGCCGGGGCTGTGGACAAACAACTGCGCCGGGTGCGTCATGGGACGGTGAAGGAACGTGCGCGCATTCTGGTTGTCGGCGGCGGCTACGTCGGGATGTACACGGCCCTGCGCCTCCAGCGGAAGCTGAAGGGCGAGCTGCGGAGGGGCGAGGTCGACATCACGGTCGTCACTCCGGACCCGTACATGACGTACCAGCCCTTCCTTCCGGAGGCCGCCGCCGGCTCGATCTCCCCGCGGCATGTCGTCGTCCCGCTGCGCCGCGTCCTGGACCGCTGCCACGTGGTCGTCGGGGAGGTGACGTCCCTGGACCACGCGACCCGCACCGCCGCCGTCAGCACGCTCGCCACCGCCGAGGAGGGCCGACCCGCCGAACTCCTCGGCTACGACGAACTCGTGCTCGCCCCCGGCTCGGTCTCCCGCACCCTGCCCGTCCCCGGCCTCGCGGAGTACGGCATCGGCTTCAAGACCGTCGAGGAGGCCATCGGCCTGCGCAACCACGTCATCGAACAGATGGACATCGCCTCCTCCACCCGCGACCCCGCCATCCGCGACGCCGCCCTCACCTTCGTGTTCGTCGGCGGCGGCTACGCGGGCGTGGAGGCCCTCGGCGAGCTGGAGGACATGGCCCGCTACACCGCTCGCTACTACCACAACATCCACCCCGACGACATGAAGTGGATCCTCGTGGAGGCCACCGACCGCATCCTCCCCGAGGTCGGCGTGGAGATGGGCCGCTACACCGTCACCGAGCTGCGCCGCCGCAACATCCAGGTGCTGCTCGACACCCGCCTGGAGTCCTGCGCCGGCCGCGTCGCCGTCCTCAGCGACGGCCAGCGCTTCCCGACCCGTACGGTCGTGTGGACCGCCGGCGTGCGACCGCACCCGCTGCTCGCCGCCACCGGCCTCCCGCGCACCGACCGCGGCCGGCTCAGGTGCACGGCCCAGCTAACGATCGACGGCACGGAGCACGCCTGGGCCGCGGGCGACGCCGCCGCCGTACCCGACGTCACGGCCGCCGTACCCGGCGCCGAGACCGCCCCCAACGCCCAGCACGCGGTCCGCCAGGCCCGCACCCTCGGCGACAACATCGCGCACTCCCTGCGCGGTGAGCCCCTGGAGACGTACGCGCACAAGTACGTCGGCTCGGTCGCCTCCCTCGGCCTGCACAAGGGCGTCGCCCAGGTCTACGGCCGCCGGCTGAAGGGCTACCCTGCCTGGTTAATGCACCGCGTGTACCACCTCAGCCGGGTGCCCACCTTCAACCGCAAGGCCCGGGTGCTCGCCGAATGGACCCTCGCCGGACTCTTCAAACGCGAGATCGTCTCGCTCGGCTCACTCGAACACCCCCGAGCGGAATTCGAACTTGCGGCCGGTGGAAAGTCCCCTCACGACCCCTCCGACGACCCGAAGGGGTCGTCCTGACCCGACCCGGGAACTCCACGGCGCGCCCCGGCGTCTGACGGTTGTCGCTCGCCGCGGCCCGCTCCCTGCCAGACTGCCCCACGACGTCGGACGGGCCACCCGCCCGCCCCAGCACCCACGAGGCCTTCCCCAAGTGAACTTCACGCGCTGGAGCGCCCGGCTCCCCGGAACGCAGCGCCGCGCTGCCGCGCGGACCAAGACGCCGGTCCCCCCGGACCGGCGGGGAGAAGGCTCCGTGCCCGCGGCCCGCGCCGAACGGTCCGCCGACGGCACACCCCCGGTGCCCGCGGTCGACGAACTGCCCGCGCGTGAAGTGCTCGACCGCGTCCCGGCCCTCGTCGCCCTCGTCCACGGCCCGGACCACCGCATCGCCTACGTCAACGACGCCTACACGGCGGCCTTCGGCACCCGGCCCACCTGCGCCCCCGCCCGCGAGGCCCTGCCCGAACTCGCCCAACTGGGCCTGTTCCCGCTCCTCGACCAGGTACTGCGCAGCGGCAGACCCCGCACCCTGAAGTCCCGCAAGGCCGTAGACGGCCGCTCGTACACCTTCACCTGCACCCCCGTCGCCGAGGACGGCGACCGCGGCGCCGGCGTACTGGTCTTCGCCACGGACGTCACCGACCACGCCGAGGCCGCCGAACGCCTGCGCGCCAGCGAGCGCCGCCAGCGGGAAACCGCCGTCACCCTCCAGCGCTCCCTGCTCCCACAGGAACTGGAACAGCCCGACGACCTGCGCATCGCCGCCACCTACCAGCCCGGCGGCACCGAGGCGGCGGTCGGCGGCGACTGGTACGACGTGATCACCCTCGGCGGTGGCCGCACCGCCCTGGTCATCGGCGACGTCATGGGCCGCGGGGTGCGCGCCGCCGCCGTCATGGGCCAGCTCCGCACGGCCGTCCGCGCCTACGCCCGCCTGGACCTCCCTCCGCACGAGGTGCTCCAGCTACTGGACGGCCTCGCCACCGAGATCGACCCCCATCAGATCGCCACCTGCTGCTACGCCGTCCACGACCCCAGCGAGGGCCGCCTGGTGTACGCCTCCGCGGGCCATCTGCCGATCCTGGTCCGCGACGAGAACGGCACCGTCTCCCGCACCGACGAACCCACCGGCCCGCCCCTCGGCACCGGCGGCTGGATGCACTCCTCCGGCTCCATCGCCCTCGGCCCCGGCGCCACGGCCGTCCTCTACACCGACGGCCTGGTCGAGCGCCGGGACGCCGACCTGGACGAGGGCATCGCCTCGCTCGCCGGCGCCCTCGCCGGGGCCACCGGCACCCCGCAGGTCGTCTGCGACCGCCTGGTCCGCTCGGCCGGGGTCACCGCCGACCACGACGACGACGTGGCCGTCCTCGTCCTCCAGCACCCCGCCCGCACGGGCCCCGACGGCGACCTCTTCCGCAACGCGGCCCTGGAACTCCTCGGCGGTGTCGAAGCGGCCCCCCGCGCGCGTGCCTTCGCCTCCGGCGTCCTCACAAGCTGGCGCTTCCCCACCGAGCTGCACGACCTCGGTGTCCTCGCCGCCAGCGAACTGGTCGCCAACAGCCTCCAGCACGGCACCCCGCCCATGCGCCTCAGACTCCGCCGCACCGACCGCCGCCTCATCGTGGAGGTCACCGACGGCGACGACCACCTGCCCCGGCGCCGCCGCGCCGAACCCGGCGACGAGTCCGGCCGGGGCATCGCCATCGTGGCGACGATCGCCACAAGCTGGGGCTGCCGCCGCACGCCGGACGGCGGCAAAGCGGTGTGGTGCGAGTTCGTCCTGCCCAAGCGCTGACCACCGCCGAGCGCCGACCCCCTACAGCCACCGCCGCTGCGGTCAGTGGCGCCGCCGCGCGGCACGGCAACGGGCGCCCTACGCCTCCGCGGCCACCGGCTCCGTGGACGCACCACCACGCGTGACCACCCGGCTGGACCGCGCCAGCCACGGCTGGTCCTGGACGGCGGTGAGCTGCCGCCCCAGCCGCAGCGCCAGGTAGGTGATTCCCAGCGAGAACAGCAGGAAGGTCACGACGTACGGCGCGTGCAGCGACGCGCCCAGAGGGCCGCCCACCGCCGGGCCGACCGCCAGCGCCAGTTGCTTGACCAGTGCGAAAGCCGAGTTGTACTGCCCGGCCATGCCCTCCGGGGCCAGATCGGCGACCAGCGGCGCGACCGTCGGCGACAGCATCGCCTCGCCCAGCCCGAACAGCGCGTACGTCGACACGAACGCGGCCGTGGCCATCTCCTGGCTGCCGTGCCCCAGCCCCGCGTACCCGGCGGCCAGCCAGGCCACGGCCCAGATCAGCCCGACCCCGGCGATCACCCGGGACCGGCGCCGCCGCTCCACGAACCTCAGCACGGCGAACTGGGCCACCACGATCATCAGGGTGTTCGCGGCCAGCGCCGTCCCCAGCGCCGAGGTGGATATCCCGGCGGCCTCCACCCCGTACGCGCTCAGGCCCGACTCGAACTGTCCGTAGCAGGCGAAGAACAGTACGAAGCCCAGCACGCACAACTGCACCATCGTCCGGTTCCCGAGCAACTGCTTCCAGCCGCCCTTCGCCGACCGCGCGGGCGCGTCCTCGATCCGTGGCGAGTGCGGCATCCGCACCGTCGCCACCACACCGACCAGCAGCAGGAACACGGCCGCCTCGATCGCGAACAGCAGCGTGAACGAGGACGCGCGGGTGGTGTCGACGAGGTGGCCGCCGATGAGACCGCCGACGCCCAGCCCCAGGTTCTGGAGGAAGAACTGCATCGCGAACGCCCGCGAGCGGGTGTCCGCCGTCGAACAGTCCACGATCATCGTCGCGAGGGCCGGCTGCATCACGGCCTGTCCGGCGCCGAGCGCCGCCGCGGAGAGCAGCACGGTGGCGGCGGCGCCCGCGAGACCGAGGCTCAGCGCGCCCAGGGCGGCGGTCACCAGAGCGGCGACCAGGACCGGCAGCGGGCCGCGCCGCACGATCGCCCGGCCGGCGAACGGCAGCACGATCAGCGCGGCCACGGCGAAGACGGCGAGCACCAGTCCCGCTGTCACGGCTCCCAGTCCCCGCACCTGCGCCACATAGACGTACAGGTAGGGGACGGTGAAGCCGAGCCCGAACGCGCTGAGTGCGTTACCCACGTGGATCCGGCGCATCGCTGCGCCCATCGCCCTGGTCACGTTCACCTCTTCCACTAGTTAGACCTGAAGACTTCGAAGCTAAAGAGTACACATCGAAGGACTTCGAGGCAAAGGAGGTGCGTGCGATACTGCGTCCATGGCCGACACCCCCGGCGTCGCGGAGCCGACACTCGAAGAACAGATCGCGGCGTACCAGCGCGAGTTCCAGGACCTCGACCCCCAGGTCGAGAAGATCGTGTCGGCGCTCTCCCGGCTGAACCGCCGCATGAACGTCGCGTACGGCCGCCAGACCGCCGCCCTCGGCATCAGCAACGCCGAGTGGGAGGTCCTCAAGGCGCTCGTGCTTTCCGGCGTCCCGTACCGCATGGGCCCCGGCGAACTGGCCAAGCGGCTCGGCCTCACCCCGGCCGCCATGACCCACCGGATCGACCGCATGGTCGCCGAGGGCCTGGTCACCCGGGACCGTGACGAGTCCAACCGCGTCCGGGTCATCGTGGAGCTGACCCCCGGCGGCCGCGAGAAGTGGCTGGAGGCGATGCGCATGGCGACCGTGTTCGAGGAGGAGCTGCTCCAGGACCTGACCCCCGTGGAGCGTGTCGTGCTCGGCGAGGTCCTGACCCGGCTGCTGCGCAGGGTGGAGCACGCCCAGCCGGACGCCGGTGGCCGGCTCAGCGACCTCGACTGAGCCGTCACCGCGGGCGACCTAAAGATCTTGACAGCAGGGTGTTGACACGCCCTTGTCTGATCCGTACAGTTCTTCGGGTTGCCGCAGAGCCGTAACGGTTCTGCGACCGCACCTCAGCCGCCTCGAGCGGCACCCTCAAACACCAGCACGACCCCTGACCGGATTGATTTCGGCGTGCCCGAATTCAAATTCGAATATGGACTCGGCGGCCCGATTGGGAATCGCCGGACGGATCGGCTAAGGTTTGAGACGTCGGAACGGCCCAACAGCCGGGAAGGCAAGCCCCCTCTGACTGGGAGTCAGACGCCGAAAGGGTCTGATAGAGTCGGAACCGCCGGAAAGGGAAACGCGGAAGCGGGAACCTGGAAAGCGCCGAGGAAATCAGATCGAGAAAAGATCTGATAGAGTCGGAAACGCAAGACCGAAGGGAAGCGCCCGGAGGAAAGCCCGAGAGGGTGAGTACAAAGGAAGCGACCGTTCCTTGAGAACTCAACAGCGTGCCAAAAGTCAACGCCAGATATGTTGATACCCCGTTCCTCTCGGTTACGAGGGGGCGAGGTTCCTTTGAAATAACACAGCGAGGACGCTGTGTGCGAGAGGATATTCCTCCTCTCGCACCGCTCTCGTGGTGTCATCCCGATTACGGGAAAACATTCACGGAGAGTTTGATCCTGGCTCAGGACGAACGCTGGCGGCGTGCTTAACACATGCAAGTCGAACGATGAACCACTTCGGTGGGGATTAGTGGCGAACGGGTGAGTAACACGTGGGCAATCTGCCCTTCACTCTGGGACAAGCCCTGGAAACGGGGTCTAATACCGGATATGACCATCTTGGGCATCCTTGATGGTGTAAAGCTCCGGCGGTGAAGGATGAGCCCGCGGCCTATCAGCTTGTTGGTGAGGTAATGGCTCACCAAGGCGACGACGGGTAGCCGGCCTGAGAGGGCGACCGGCCACACTGGGACTGAGACACGGCCCAGACTCCTACGGGAGGCAGCAGTGGGGAATATTGCACAATGGGCGAAAGCCTGATGCAGCGACGCCGCGTGAGGGATGACGGCCTTCGGGTTGTAAACCTCTTTCAGCAGGGAAGAAGCGAAAGTGACGGTACCTGCAGAAGAAGCGCCGGCTAACTACGTGCCAGCAGCCGCGGTAATACGTAGGGCGCAAGCGTTGTCCGGAATTATTGGGCGTAAAGAGCTCGTAGGCGGCTTGTCACGTCGGGTGTGAAAGCCCGGGGCTTAACCCCGGGTCTGCATTCGATACGGGCTAGCTAGAGTGTGGTAGGGGAGATCGGAATTCCTGGTGTAGCGGTGAAATGCGCAGATATCAGGAGGAACACCGGTGGCGAAGGCGGATCTCTGGGCCATTACTGACGCTGAGGAGCGAAAGCGTGGGGAGCGAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAACGGTGGGAACTAGGTGTTGGCGACATTCCACGTCGTCGGTGCCGCAGCTAACGCATTAAGTTCCCCGCCTGGGGAGTACGGCCGCAAGGCTAAAACTCAAAGGAATTGACGGGGGCCCGCACAAGCAGCGGAGCATGTGGCTTAATTCGACGCAACGCGAAGAACCTTACCAAGGCTTGACATACACCGGAAAGCATTAGAGATAGTGCCCCCCTTGTGGTCGGTGTACAGGTGGTGCATGGCTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCTTGTCCTGTGTTGCCAGCATGCCCTTCGGGGTGATGGGGACTCACAGGAGACCGCCGGGGTCAACTCGGAGGAAGGTGGGGACGACGTCAAGTCATCATGCCCCTTATGTCTTGGGCTGCACACGTGCTACAATGGCCGGTACAATGAGCTGCGATACCGTGAGGTGGAGCGAATCTCAAAAAGCCGGTCTCAGTTCGGATTGGGGTCTGCAACTCGACCCCATGAAGTCGGAGTTGCTAGTAATCGCAGATCAGCATTGCTGCGGTGAATACGTTCCCGGGCCTTGTACACACCGCCCGTCACGTCACGAAAGTTGGTAACACCCGAAGCCGGTGGCCCAACCCCTTGTGGGAGGGAGCTGTCGAAGGTGGGACTAGCGATTGGGACGAAGTCGTAACAAGGTAGCCGTACCGGAAGGTGCGGCTGGATCACCTCCTTTCTAAGGAGCACTTCTCACCAGCTTCGGTTGGTCAGAGGCCAGTACATCGGCGAATGTCTGATGCTGGTTGCTCATGGGTGGAACGTTGACTATTCGGCACACTCGGCCTGCTTCAGGTCACTAGTACTGCTTCGGCGTGGAACGTGAGTTGGGTGGGGTGAGGGTGTCGGGCACGCTGTTGGGTGTCTGAGGGAATGGATTTTTCCTCAGTCGCCGGCCCCAGTGCACTCGGACTTCTGGTTCGGGGTGATGGGTGGCTGGTCGTTGTTTGAGAACTGCACAGTGAACGCGAGCATCTGTGGCCAAGTTTTTAAGGGCGCACGGTGGATGCCTTGGCACCAGGAACCGATGAAGGACGTGGGAGGCCACGATAGTCCCCGGGGAGTCGTCAACCAGGCTTTGATCCGGGGGTTTCCGAATGGGGAAACCCGGCAGTCGTCATGGGCTGTCACCCTTGCCTGAACACATAGGGCAAGTGGAGGGAACGCGGGGAAGTGAAACATCTCAGTACCCGCAGGAAGAGAAAACAACCGTGATTCCGGGAGTAGTGGCGAGCGAAACCGGATGAGGCCAAACCGTATGCGTGTGAGACCCGGCAGGGGTTGCGTATACGGGGTTGCGGGATCTTTCTTTTACGGTCTGCCGGCCGTGAGACGAGTCAGAAACCGTTGATGTAGGCGAAGGGCATGCGAAAGGCCCGGCGTAGAGGGTAAGACCCCCGTAGTCGAAACGTCAACGGCTCGTTTGAAAGACACCCAAGTAGCACGGGGCCCGAGAAATCCCGTGTGAATCTGGCGGGACCACCCGCTAAGCCTAAATATTCCCTGGTGACCGATAGCGGATAGTACCGTGAGGGAATGGTGAAAAGTACCGCGGGAGCGGAGTGAAATAGTACCTGAAACCGTGTGCCTACAAGCCGTGGGAGCGTCGGAACGAGGCTTGCCTTGTTCTCGTGACTGCGTGCCTTTTGAAGAATGAGCCTGCGAGTTTGCGGTGTGTTGCGAGGTTAACCCGAGTGGGGAAGCCGTAGCGAAAGCGAGTCCGAATAGGGCGTTTCAGTAGCACGCTCAAGACCCGAAGCGGAGTGATCTAGCCATGGGCAGGTTGAAGCGGAGGTAAGACTTCGTGGAGGACCGAACCCACCAGGGTTGAAAACCTGGGGGATGACCTGTGGTTAGGGGTGAAAGGCCAATCAAACTCCGTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGCAGCGTCGTGTGTTTCTTGCCGGAGGTAGAGCACTGGATAGGCGATGGGCCCTACCGGGTTACTGACCTTAGCCAAACTCCGAATGCCGGTAAGTGAGAGCGCGGCAGTGAGACTGTGGGGGATAAGCTCCATGGTCGAGAGGGAAACAGCCCAGAGCATCGACTAAGGCCCCCAAGCGTACGCTAAGTGGGAAAGGATGTGGAGTCGCACAGACAACCAGGAGGTTGGCTTAGAAGCAGCCACCCTTGAAAGAGTGCGTAATAGCTCACTGGTCTAGTGATTCCGCGCCGACAATGTAGCGGGGCTCAAGCGTACCGCCGAAGTCGTGTCATTCATACAATAGGGCCAACGCCTGTATGGATGGGTAGGGGAGCGTCGTGTGCCGGGTGAAGCAGCCGCGGAAGCGAGTTGTGGACGGTTCACGAGTGAGAATGCAGGCATGAGTAGCGATACAAACGTGAGAAACGTTTGCGCCGATTGACTAAGGGTTCCTGGGTCAAGCTGATCTGCCCAGGGTAAGTCGGGACCTAAGGCGAGGCCGACAGGCGTAGTCGATGGATAACCGGTTGATATTCCGGTACCCGCTGTGAAGCGTCAAACATCGAGCATCGTGATGCTAAGGCCGTGAAGCCGTTCCGGACCCTTCGGGGAAAGGAAAGTGGTGGAGCCGCCGGACCAAGCGGTTAGTAGGTGAGTGATGGGGTGACGCAGGAAGGTAGTCCATCCCGGGCGGTGGTTGTCCCGGGGTAAGGGTGTAGCCCGAGTGGTAGGTAAATCCGTCACTCATGCAGGGTGAGACCTGATGCCGAGCCGATTGTGGTGAAGTGGATGATCCTATGCTGTCGAGAAAAGCCTCTAGCGAGTTTCATGGCGGCCCGTACCCTAAACCGACTCAGGTGGTCAGGTAGAGAATACCGAGGCGTTCGGGTGAACTATGGTTAAGGAACTCGGCAAAATGCCCCCGTAACTTCGGGAGAAGGGGGGCCATGTCCGGTGATGAGCTTTACGCTCTGAGCTGGGGGTGGCCGCAGAGACCAGCGAGAAGCGACTGTTTACTAAAAACACAGGTCCGTGCGAAGCCGTAAGGCGATGTATACGGACTGACGCCTGCCCGGTGCTGGAACGTTAAGGGGACCGGTTAGCTCACTTTCGGGTGGGCGAAGCTGAGAACTTAAGCGCCAGTAAACGGCGGTGGTAACTATAACCATCCTAAGGTAGCGAAATTCCTTGTCGGGTAAGTTCCGACCTGCACGAATGGCGTAACGACTTCTCGACTGTCTCAACCATAGGCCCGGTGAAATTGCACTACGAGTAAAGATGCTCGTTTCGCGCAGCAGGACGGAAAGACCCCGGGACCTTTACTACAGTTTGATATTGGTGTTCGGTTCGGCTTGTGTAGGATAGCTGGGAGACTTTGAAGCAGCCACGCCAGTGGTTGTGGAGTCGTCGTTGAAATACCAGTCTGGTCGTGCTGGATGTCTAACCTGGGTCCGTGATCCGGATCAGGGACAGTGTCTGATGGGTAGTTTAACTGGGGCGGTTGCCTCCTAAAGAGTAACGGAGGCGCCCAAAGGTTCCCTCAGCCTGGTTGGCAATCAGGTGTTGAGTGTAAGTGCACAAGGGAGCTTGACTGTGAGACCGACGGGTCGAGCAGGGACGAAAGTCGGGACTAGTGATCCGGCGGTGGCTTGTGGAAGCGCCGTCGCTCAACGGATAAAAGGTACCCCGGGGATAACAGGCTGATCTTCCCCAAGAGTCCATATCGACGGGATGGTTTGGCACCTCGATGTCGGCTCGTCGCATCCTGGGGCTGGAGTCGGTCCCAAGGGTTGGGCTGTTCGCCCATTAAAGCGGTACGCGAGCTGGGTTTAGAACGTCGTGAGACAGTTCGGTCCCTATCCGCTGTGCGCGCAGGAGTCTTGAGAAGGGCTGTCCCTAGTACGAGAGGACCGGGACGGACGAACCTTGGTGTGCCAGTTGTCCTGCCAAGGGCATGGCTGGTTGGCTACGTTCGGGAGGGATAACCGCTGAAAGCATCTAAGCGGGAAGCCTGCTTCGAGATGGGACTCCCACCCACTTGATGGGGTAAGGCTCCCAGTAGACGACTGGGTTGATAGGCCGGATCTGGAAGCACGGTAACGTGTGGAGGTGACCGGTACTAATAGGCCGAGGGCTTGTCCATTGATGCTCGCGTTCACTGTGTTGGTTCTGAAACCACGACCACGTCACCCCGTATGTGTGGGGTGTTTCGGTTGAAGTGTTTCATAGTGTTTCGGTGGTCATAGCGTGAGGGAAACGCCCGGTTACATATCGAACCCGGAAGCTAAGCCTTACAGCGCCGATGGTACTGCAGGGGGGACCCTGTGGGAGAGTAGGACGCCGCCGAACAATCTTTGGGAAAACCCCCGCATCTTCGATGCGGGGGTTTTCTGCGTTTGTCCCCGTTACGGATGACAGCCGCTAGAAGGTGACTTCTGCGGTGTCCACCGCTCCGCCCCGGCGGCCGGGTGCCGCTTGCCACTTCCAGTACAGGTTGGTGTGGGTGATGACCTGCTCCGGGGTGGGTGCGCCGTACGCGGTGTGGTCCGCCGTGGTGTGCGCGTCGGCGACCAGCGTCGCGTCGTAGCCACGGACGATCGCGCCGTGCAGCGTGGAGCGGATGCACGCGTCCGTCTGGGCGCCCGCCACGACGAGCCGGCCCACCTTGTGCCGGGCGAGGACGTTCTCCAGCTCGGTCTCCTCAAAGGAGTCCGGGTAGCTCTTGTGGACCAGCGGCTCGTCGGCCTCACGGACGAGTTCCGGGACGTACTGCCAGTTGTCGCTGCCCTTCTGCAGTGCGTCGTCCGAGTGCTGCACCCAGATCACCGGTACGTCGGCCGCGCGTGCCCTGCCGATGAGGGCGTTGATGTTGGCGATGACGTCGTCCCGTCGGTGGGCGCCGGCGACCACGTCGTTCTGGACGTCGATGACGAGCACCGCGGTGTTGGGTCGGTCGTTGAGTGTGGTCATGCTGTCAAAATACGGGGTACCACCGACAACGCGTGGTCTACGGTGACCACATGACCAGCCCCTACCGGTGAACCTGGCCTGACCAGGGACGACTACACCGTCCGTGCCATACGTCCCGACGAGTGGGCCGCCGTGCGGCGGCTGCGGCTCGACGCGTTGCGGGATCCGGCCGCGGGTATCGCCTTTCTGGACACCTACGATGAGGCCGTCGGCAGGCCGGACGACTTCTGGCAGGACCGGGCCGTCGGGTCCGGGGAAAACTCCACGACGGCCCGGCAGTTCATCGCCGAGGCCCCGGACGGGTCGTGGGCCGGCACCGTCACCGTGCTCGTCGAGGAGGCAGGGACGAAGGACTGGGCCGGGTATCCGGTCGAGCGGCGGCAGGGACATGTCGTGGGCGCGTACGTCCGGCCGGAACACCGCGGGAACGGGTTGATCGAGGCGCTGTTCGGCGCCGCTCTGGACTGGGCCTGGCAGCAGCGGGCGGAAGCGGGTGCGGCTGATCGTGCACGAGGACAACGTGCGGGCGCAGGGCGCGTACCGGAAGGTGGGGTTCGTGCCGAGCGGTCTCGTCGTGGCGTTCTCCCACGACGAGACCGAGAACGAGCTGGAGTTCGTCCTGGAGCGGTAGGCAACCTAGACCGGCAGTTCCCGGTGCGGCCAGCGGGAGCGGGCCTGTTCGCGCGAGCGGAGCAGGGCCAGTGTCGGCAGGCCCTGGTCGGTTCCGGTGGCGAGCAGGGCCGGCAGCTCGGGGAAGGGTGCCACGGCCGCGATGTCGTCCAGCACCAGGGTGAGTGGTGGGTCGAGCCGACCGGAGGATGACCGTTCGGCCATGCGCCGGCCGTGCTCGACCACGCTGGAGACGAGGGCCGTCAGGAGCGGCATCGCGCCCGGGTTGCTCCTGGGGTCCTCGATGGATTCACCGACCACATAAAGTGTGCCCCCCTTGTGGATGAAGGAATCCAGGGCGAGGGCATCGGTTCGGTTCGGGGTGCAGGCCTCGCGGATGTTGACCGTGAAGAGGGCGGACAGGGCCCTGCTCGTCAGTTCCTGGGCGATGTCCCGGCGTTCGGGGTGCGCGGTGAGGGCCGCCTCTAGTTCGCCGGCGGCGCCGGGGGCGGCCTTGGAGTGGGTGCGCAGGGTGCGTACGGCGTCCTGGACCTGGGTGCCCTGGGCCCAGCGGTGGACGTGGCGGATGGTGCGGTTCTCCAGGGCGGCGGCGTGGAGGTAGCTGCGCAGCAGGGTGGTCGCCGTGTCGGCCACGGCCTGGTCGATCCTGGCGGTGGGGCGTACGGGGCCGAGGAGGGCCGTCGCTCTGAGCAGCGCCGTCTGCCTGTCCGCGCAGCCCGCCGTGGGGGACCAGTGGAGGCGGGCCGGGGTGTCGCAGAGGTGCGTGGGGTCGTAGAGGAGGGTGGGGCCCAGTTTGGCCCTCGCGTCCTTCGTTTCCGTCCAGAGGGCCGGGTTGGACGTGACGACGAGGGTGGGGCCGGCCGCGTCCCGGATGGCCTGGACCGCGGCCGGCCGGCGGGTCGCGGGGGCGCCGTAGAGGACCTGGCCGTCGGTACGGGGGGTTTCCCATCCGCCCCTTCGCGTACCGCCGGCCGGGAAGGTGCCGGTCCCCTGCGGCTCGGGCTCGCTGCGAGGCGCCGGGATCTCGTGCGCGGGCGCGGGAGGCGGAGTGGGTGTGGGCGGCGGCGTGGGTGCCGGTGAGGGCGTTGCGGGGACCATCTCGAGTGGCGGACTCGCGACCGCGGGTTCGGGGGCGATGAAGCCGGTGGCCACGGGTCCGCTGACCCCCGGGTCCACCGACGCCGGGCCCGCTCGTCACAGGTCCACTGACCCCAGGCCCAGTGGGCACAGGTCCGCTGATCACAGGTCCCCCGGTCCCGGTCCCGGCGTTCGTCAGCCCACCGCGTCTCGCCGTCGCCCGGCGGGCGCGCCACCGGGTCACCGTGCCGATCACGAACAGGGTGAGGACGAAGAGGGTCATGAGCTGGCCGATGAACAGGCCCCAGAACAGGCCCCAGCCGGACAACTGGGCCGGTGGGGTGTCCGGCCAGGCGCCGGTGATGTCGTGGGGCCGGGCGACGAGATGGCGCATGGCCAGGGGGGTCCGGGTGAAGGTGACGCCGTGGGGCCAGGCGCCCTGGGCGAACCGGGCCGCCAGCCCCGTGGCCGTCCACACCAGCAGGGTCATGCCGAGGAGGAACGCGAGCAGGCCGACCAGCAGCCCGTCGGGGATGCCGCCGCCCCGGCCCTGCCCGCGGCTGTCACGGCGGTCGTCCGGTCTCACCCCGCCCCTCCCTACGCCACCGTCGACTCGGAGTCGCCCAGATGCTGCTGCTCCACGAAGGCCGCCGCCCGCTGCTCGGCCTCCAGCTCGGCCGCGCGCAGGGCCTCGTCGGCCGCCAGGTCGCTGGAGGACTGTGTCATCGCCCGGTCGGTGAAGACCAGCGGGCGTTCCGTCTCCGTGATCAGGTGTTTGACCACCTGGACGTTGCCGTTGACGTCCCAGACCGCGATGCCGGGGGTGAGCGTCGGGATGATCTCGACCGCCCATCTGGGCAGGCCCAGCACCCGGCCGGTGGCGCGTGCCTCGTCGGCCTTCTGGGCGTAGATCGTCCGGGTCGACGCCATCTTCAGGATGGCCGCCGCCTCCTTCGCGGCGGCGCCGTCGACCACGTCGGACAGGTGGTGGACGACGGCCACGAAGGACAGGCCGAGCCGCCGGCCGAACTTCAGCAGGCGCTGGAACAGCTGGGCCACGAAGGGGCTGTTGATGATGTGCCAGGCCTCCTCGACCAGGAAGATGCGCTTCTTCCGGTCGGGGCGGATCCAGGTGTGCTCCAGCCACACGCCGACGATCGCCATGAGGATGGGCATGGCGATGGAGTTGCGGTCGATGTGGGAGAGGTCGAAGACGATCAGCGGGGCGTCGAGGTCGATGCCGACCGTGGTCGGGCCGTCGAACATGCCGCGGAGGTCGCCGTCGACCAGCCGGTCCAGGACCAGGGCGACGTCGAGGCCCCAGGCGCGTACGTCGTCTATGGCGACGTTCATCGCCTCCGCCGAATCGGGCTCGGGGTGCCGTAGCTGCTCGACGATGTCGGTGAGGACCGGCTGGCGGTCGAGGATGGTCTCGTTGACGTACGAGTGGGCGACCTTGAGGGCGAAGCCGGAGCGTTCGTCCAGGCCGTGGCCCATCGCCACCTCGATGATCGTCCGGAGCAGCGCTAGCTGGCCGGTGGTGGTGATCGCCGGATCCAGGGGGTTGAGCCTGATCCCGTGGTTCAGGGCGGCCGTCGGGTCGAGCCGGATGGGGGTTATCCCCAGCTCCTCGGCGATCAGGTTCCACTCGCCGACCCCGTCCTCGCCCTGGGCGTCCAGGACGACGACCTGGCGGTCCTTGAACCGCAACTGGCGCATGACGTACGTCTTCTCCAGCGCCGACTTGCCGTTGCCGGACTCGCCGAGGACGAGCCAGTGGGGGGCCGGGAGCTGCTGGCCGTACAACTGGAAGGGGTCGTAGATGTATCCCTTCCCGGAGTAGACCTCGCGGCCGATGATGACGCCGGAGTCGCCGAGGCCGGGGGCGGCCGTGGGCAGGTAGACGGCCTGGGCCTGGCCCGTGGAGGTGCGCACCGGCAGCCGGGTCGTCTCCACCTTCCCGAAGAGGAAGGAGGTGAAGGCGTCGGTGAGGACGGACAGCGGATCCCGCATCGGCGAATCAGCCCCTACCTTCGGATGCCGGTGGCGAACGGAAGTGTGTTCACGAAGGCGCGGTGGTGCTCTCGGTCGCACCATTCCAGCTTGAGGTACGACTTGCCGGCGGAGGCCCTTATCGTGCGCTTGTCGCGGGCGAGGGCCTCGGGGGAACGGGAGGAGACGGTGATGTAGCCGACGAGGTTGACGCCCGCGGCGCCGCTGGCGAGGTCCTCGCCGCGCTGATCGAGACGGTTGTGGGCGGCGATGTCCCGGGGGTCCACGGTGCGGTTCATCTTGGCGGCGCGGGACGCCTCGGCCTCGTCGTTGGTCTTCTCGGTCAGCATGCGCTCGATGGCCACCTCGGTGGGCTCCAGATCCATCGTCACGGCGACCGTGCGGATGACGTCCGGGGTGTGGACGAGGAGGGGGGCGAGGAAGTTGACGCCGACCGGGGTCATCGGCCACTCCTTCACCCAGGCGGTGGCGTGGCACCAGGGCGCCCGGGTGCGGGACTCGCGGGTCTTGGCCTGGAGGAAGGTGGGCTCCATGGCGTCCAGCTCGGCCGGCCAGGCGTTGCGCTTGGTCATCGCCTGGATGTGGTCGATGGGGTGGTCGGGGTCGTACATGGAGTGGATGAGGGAGGCCAGCCGCCCCTGGCCCAGGGGCTGCCGTACGCGGATGTCGGCCTCCTGGAGCCGCGAGCAGATGTCGGTCAGCTCACGGGCCATGACGACGGCGAGCCCGGCGTCCCGGTCGACCTTGGTGCCGTGGGCGCGGACGGCACGGGCCATGGCGTTCGCCTCGGCGGCCAGGTCGCGGGTGTAGTGCATGCAGGCGACGAGGTAGGCGCGGTGCTGCTCGCTGCTGGTGGACACCATGGACTGCAACTGGTCGTAGGACCGCTGGAGCCAGTCCGGGGAGCGGTCGTCGCCGCGCTGGGTGACGTCCTTGGCGTGCGCGTCCGGGTCCGCCGGCAGGGTGCGGGCGAGCATCTGGATGCGGGTGACGAAGCCGTCCCCGTTGGCGACGTGCTTGAGCAGTGTGCCGAAGCGGTCGACGAGGGCTTCCTGGTCCTCGGAGTCGCGCAGGCCGACGCCCGGGCCCTCGATCTCGATGGCGGCCGTGACCGTCTTGCGGTCGGCGTGCAGCAGTACGGCGATCTCGTCGGGCCCGAAGGGGGCGGCGAGCCAGTTGATGCGTCCGATGCCCGGGGGAGGGCCGATCTCTACCTCGCGGCCGTCGAGGCCGGTGCCGGCCTCCATGACGGTCGAGCGGTAGTGGGGGCCGCGCTTGACGGTCCGTTTGTAGCTGCGGTTGATCTCGAACCACTTGTAGAAGGTGCGGCGCTTGTACGGCACGTAGACCGCGGCGAGCGCGAGCAGCGGGAAGCCGGTCAGCAGCACGATGCGCAGGGGCAGCACCGGGACGAGGAGGCCGCACATCATGCCGAGGAACGCGCCGATGACGATCAGCGCGATCTCGCCTGACTCGCGGTTGCGGCCGACGATCGCGTTGGGCCGGGCGCGGCCGATCAGATACGTACGGCGGGGCGTGATCGGATGGGACAGATGGGACTCGGTCGTCAACGCCCTTCACCTCCTGAGCGGTTGTTGCGGGTGTTGCTGGCGTGCGGGGTGTTCACCGGGCTGGCCGCGCGGGGCGCGGGCGCGGCGGAGGGGACTGCTCCGCCGGAGCTCCCGGAGGGGGTACGGCTGCTGTGGGCGGCGACACCGCCGGAGACGGGGTTGGCCGGGCGCGGGGCGCTGCCGGACTGGCCTCCGCCGCCGTTGTTGTCGGCGCGGGTGCTGTGGGTCTTGATGCCCTGGGCGACGAGGGTGGCGGGTGAGCTGATCACGGCGGCGGCCTTGCCCTCGGCGCCCTGCATGATGCGGTTGCTGCGGGAGCCGGCGATCTCGTCGCCGAAGCCGGGGACGAAACGGTAGATCATCGCGCTGGCGAAGATGGCGAGCAGGATGATGGCGAGGCCGGAGACGACGGCGGAGAAGGCGTCGGGGCCGTCGGCGCCGGAGAGGGCTCCGGCGAGGCCGAGCACGATGACTATGACCGGCTTCACCAGGATGACCGCGATCATGATGCCGGCCCAGCGGCGTACGTGCCCCCACAGGTTCTTGTCCACGAGTCCGGCGTAGACGACGGTGCCGAGGAGGGCGCCGACGTAGAGCAGGGCGGCGCGGATGACCAGCTCCAGCCAGAGGATGCCGGCGGCGAGGATGCTGACCAGGGAGACCACGATCAGCATGATGGGGCCGCCGCCGATGTCCGTGCCCTTGTTCAGGGCGCCGGAGAAGGTGCCGAAGAAGGTGTCGGTCTGGTCGCCGGTGGCCTTCGCGAGGACGTCCGTGACGCCGTCCGTCGCCGACACGACCGTGTACAGGATCAGGGGCGTGAAGGCGGAGGCGAGCACCGTCAGCCACAGGAAGCCGATGGCCTCCGAGATGGCGGTGGTGAGCGGGACACCGCGGACCGCCCGCTTGGCCACGGCCAGGAGCCACAGGAGGAGGGTGAGGATCGTGGAGGCCGCGAAGACGATGGCGTACTGCTGGAGGAACTTGGGGTTGGTGAAGTCTACGTTGGCGGTTTCCTTCACGGCTTTACTGAGCTTGCCGACGGTCCACGCGGCGGCTTCGGCACACCCTTTACCGAGAGAGGAAAGGGGGTCGAGGGTGTCGGTCAGGGGGTTGTTGGTGCCTAGCTTCCCCCCTTTGGAACTACCGCCGCCTTTTTCGCAGTATTGCTTGGCGGGACCTCGGATCAGGTCACAGGGATCGTTGCTCTTGCTGGGCGACGGAGAGGGCTCGGCGAAGGCGGGGGTGGCCAGCAGCAGCGCGGCTGTCTGCACGGTTCCGACGACGGTGGCGATCCTGCGGACACGGTGGTTAGCGCGCATACGTGAACCCTCCATACTCCTCGACGGCCTTCGTCATGTCGTCAGCGGTGGAGGCCTTCTGGTCACGGCCCACGGGAACGGGTCCGTCCTTCTGCTGGAAGTCGGTGACCTTCCAGTCGTCGTTGACCCACTTCAGTTCGTACGTCGTGGTGAACCAGCTTTCGGTCACCGGGTTGGTCGAGGCTTCACCCGAGAGGCCGAACAACGAGGTGTACCAGACCTCGACTTTTGCGCTGTCCGCTCCCATTGAGGTGACCTTGGTACCTACGGGAATGACACGAGATACGAAGTTCTGCCCTCTGGGAGGGGTGCCGTCCTTCGTGAGGCCGATATTGGAGAGGAAGCTTTCATTGGAGTAGGCGCTGTCCAGAGCCGACTGCCTGGCGGCAGCGATGGCCGGTGCGTAGACCGCGAGTACGATCTCGTGCCGTCGTGCTGCGCTGAACATGTCGGCAGATCCCAAAACCACCGCATAGTTCGCCGCCGCGCTCTGTGCTCCCTGTTCCGTGCGGGGGAAGCCTGAGGGGATGCCTGTTGTTCTGGTGCCGACGGGGTGGGTGCCTGAGGGGGCTGTCGAGGAGGTCTGGGGGCGGGATCCCTTGGTGGTGGCGGTGTCCGTGGGTGTGTCGTCGCCTCTGTTTGCGAAGGCGATGGCTGCGATCAGGAGGACCACCACGCCGACCACTGTGACCAGGCTTTTGGAGGAGGACCGGTGGGGGCGGCGGGGGGCGCCGCCGTAGGGGTCGTTCTCCGGTAGACGGGTCCGGGTGTGGCCCGTGTCGCCGTAGTCGGTGTAGCTCTGTTCGTCTCCGGGATTCATGCCGCGTACGCCCCCTCCACCTCGTAGACGTACGACGGTAGCCGTGCTGGTTCCCGCGCGGGCGCGGTGTGGTGACTCGACATCAGGGAAACGCAACCTCAGCCGGTGGGCACGACGGGTGGGTGGGGTGGAGGGGACAGCCGTGGCCGGGCGTGCCCGGGAGGGGAGGGGTTACACCGCCATGCCGTACACGATGGTGAACAGGGTGCCGAGGGAGCCGATGATGAAGACTCCGGTGAGGCCGGCGATGATCAGGCCCTTGCCCTGTTCCGCGCTGAAGGTGTCCCGCAGGGCCGTGGCGCCGATGCGCTGCTTGGCCGCGCCCCATACCGCGAGACCGAGGCAGAGGAGGATGGCCACGGCCATGACCACCTCGATCATCACCTTGGCCTCGTTGCCCAGGCTGCCGAAGGGGCCCCAGTCCGGAGCGATCCCGCCGATGATGGTGTTGATGTCTCCCTTGTCGGCCGCAAAGAGCATGTAAGTCACCGCCCCTGGTGGGTAGTTCCGCGTGAGCCTCTGCGGTGTGCAGAGGTCAGGCCTCATTGTCGCCGACAACGCCGCCTACGTATGTCGACTTGGCGTCATTGACTGGCGGGTTTCGTGCGAATGGCCCGCACGGTCACTCTGTGTATCACGGCAGGTCACCGCGGGCAATGAGGTCGAAGCGGAACCTGGCGTGTGGTGCGGTCGTTGACCTCTTTCACGGCCGCCGTCGTTCTCGGGCGCGGTGTCTGACGGCCGGTCGGGTGAGGCTTCGTGCCGATGTTCTCACGGGCGGTGGGGCGGATGCCGTGGCCGACCCGGCCGTCATCGTCGGCGTGGCTACCGTCCGACCCGTCCGTGCCGCAGGTCTCGGTGGAGCAGCCACGCCGTGCCTGCGACGACCGTCCCGCAGACCGTGGGCACGAGCAGCCAGGGGAGGCCCGCCCACACGGTGAGGAAGCCCACGACGGTGCAGGCGGCCACCGTGACGAGGCACAGCCACATGCCGTACGGGCGCCAGGTGAAGAGGCCGGGGCCGCGCGGCCTGGCCAGCCGCATCACGCCGAACAGCAGCGCCAGGGCCGCCAGCAGCCCCGTGAACGTGCCGAGGGCGGCGGTCATCTGGGGTTCGTCGCGCGGCGCGTCGGAGGAGTTCTGCCGGTCGTCCCCGGCGGCGACCACCACGACGACGCCGCGCCAGAGGGTTGCGGTGACCCGGTCCCCCCGCTCTAGCTCGCTCAGCACCGGTCCGGAGTCGCCGAACGGCACGACCATCTCGGGGAAGGGCTCGCGACCGTGCAGGGTCGCCCGCATGTACTTGGGGGTCTTCCGGGTGTCCTCGACGGTGAAGGTGACCTTTCGCAGGCAGTCCTCCGACCTCGGTGTCACCGTGCGGGCGGGGCACGCCTTGGCCGCCTCGTACTCCCGGTACAGGGCGCGATCGCCGGGCAGCCAGGTGGTGAAGACGAAGTGGCAGGTCAGTGCGGCGGCGAGGGACGAGAGCAGCAGTGCCGCGCCCACCAGCCGGTTCCGGCCGGCCCTCGGTGGGGGCGGCGGCGATCCGGCCGCCTCCTGGACCGTGCCGGTTCGCATGGTGGTCATCGCTCGTCTCCCCCGCCGTTCCCCGCGACATACGAAGGACACCAGTCTCTTCCATCGGTGATCAAGCGGACAAGGAGACCGGGCCGCAGTCCCCGCCGTCCTTCGGCGGCCGGCCGGTACGGCCTCCCAACGGTCGTCCCGGGCGCGGCCGCGCCCCTGCTGTCCCTTGGGCTTTCGGCTCTGCGGTGGCGGGGCACCCGATGTTCACAGGACAATCTCAGTGATGTCGGAGCGGGTTTCTCAGCTTCGTGGGACAGAGTGGGGCTTGATGAAGCGCATCTCACGCATCTCACGCATCTCGGTCACCTCCCGGCCCGCGCTGCTCGGCGCGGTGGTGATGCTCGCGCTGACCTCGGCGTCGGTGGCCGCCGCCGACGACGGGCCGGGGCCTCTCGGGGTCACGGCCGATGCGGTCGCGACCCGCCAGAGCGCGCGGGTCGGGGCGCTGTTCGACGCGGACCGGGCGGGCAGGCCGGCCGGTGGCCACTTCTGCACCGCCTCCGTGGTGCACAGTCCGCGCGGCGACCTCATCGTCACCGCCGCGCACTGCGTGGACGGCGATGACGGCGATCTGGTGTTCGCGCCGGGCTACCGGGACGGACAGGCGCCGTTCGGGATGTGGAAGGTGATGCGGCGGTTCCTGCCCGACGCGTGGACCAGCGGTCAGGACGAGGACAGTGACCTCGCCTTCGCCGCCGTCGCCGAGCGGGACGGTGAGCGGCTCGAGGACGTCGTCGGGGCCAACCGGTTCGCGGCCGGGGTGGCCACCGGTGCCACCGCCGTGACCGTCATCGGCTACCCGGACTCCCGCGAGGCGCCCGTCACCTGCACCGACAAGCCGGCCTCGCGCAGCGACACCCAGCAGCGCGTCGAGTGCCCGGACTTCACCGGTGGCACCAGCGGCAGTCCCTGGGTCAACGGTGACGGCCAGGTCGTCGGGGTCATCGGCGGCCACGAGCAGGGCGGGGCCACGGCCGACGTCTCCTACAGCGTGGTGCTGGGCGGCGAGGCGGCCGAGCTGTACCGGGACGCGATGTCCGCGTCCTGA

Protein sequences of DBSCAN-SWA_2

>CP033073|4175120:4231425|4212996_4214292_-|AYN43741.1|DBSCAN-SWA
MNVTRAMGAAMRRIHVGNALSAFGLGFTVPYLYVYVAQVRGLGAVTAGLVLAVFAVAALIVLPFAGRAIVRRGPLPVLVAALVTAALGALSLGLAGAAATVLLSAAALGAGQAVMQPALATMIVDCSTADTRSRAFAMQFFLQNLGLGVGGLIGGHLVDTTRASSFTLLFAIEAAVFLLLVGVVATVRMPHSPRIEDAPARSAKGGWKQLLGNRTMVQLCVLGFVLFFACYGQFESGLSAYGVEAAGISTSALGTALAANTLMIVVAQFAVLRFVERRRRSRVIAGVGLIWAVAWLAAGYAGLGHGSQEMATAAFVSTYALFGLGEAMLSPTVAPLVADLAPEGMAGQYNSAFALVKQLALAVGPAVGGPLGASLHAPYVVTFLLFSLGITYLALRLGRQLTAVQDQPWLARSSRVVTRGGASTEPVAAEA
>CP033073|4175120:4231425|4220808_4221357_-|AYN40606.1|DBSCAN-SWA
MTTLNDRPNTAVLVIDVQNDVVAGAHRRDDVIANINALIGRARAADVPVIWVQHSDDALQKGSDNWQYVPELVREADEPLVHKSYPDSFEETELENVLARHKVGRLVVAGAQTDACIRSTLHGAIVRGYDATLVADAHTTADHTAYGAPTPEQVITHTNLYWKWQAAPGRRGGAVDTAEVTF
>CP033073|4175120:4231425|4193768_4194722_+|AYN40595.1|DBSCAN-SWA
MTSTTSPRTLGSSDLQVFPLALGGNVFGWTADEQTSFAVLDAYTAAGGNFIDTADSYSAWIEGNQGGESETIIGKWVKARGNRDDVVIATKVSQHPEYQGLSAANIKAAADASLRRLDTDHIDLYYTHFDQPEVPVEEIIGALDELVRAGKVRHIAASNISPERLRASLDHSDREGLARYVALQPHYNLVSRDTYEGPLQDLAARENLAAVPYFSLAAGFLTGKYRPGTTVDSARAGTAQKYADSERGRRVLAALDDIAAAHEAPVATVALAWLAAQPTVTAPIASARTVEQLPALLGVADLKLTDDELATLTTASA
>CP033073|4175120:4231425|4194776_4196081_-|AYN40596.1|protease|DBSCAN-SWA
MATSPAFPTYPPSPVGGALRHPHWWQRTWVRYGALSTLLALSGLVILALVRRQTGTEGFVVGLGLAVLPVPWLTAAFRWLDRVEPGPRRNLVFAFAWGACAAALIAIVANSFATRWIATSTADPAGADTLGATVIAPIVEESAKAAAVLLVFLFRRRDFTGIVDGVVIAGITATGFAFTENILYLGTAFGTDQLTGDRGIASVTAATFFVRIVMSPFAHPLFTVLTGIGFGVAALSGERQHVRRVLLPVCGLLLAMSMHAFWNGSSTFGEYGFFAVYAAFMLPAFALLTWLAIWTRQRELRTVRAELPAYVLAGWLGPAEPFALGSMRARRMARDYARHHFGRPAAREVARYEACATSLAFLRHRGRRGRAGADFVVRERELLDELWRRRQPARPALEYAARAATPPRPVYAGPMPYWQGAPAGAYPAYNPYRS
>CP033073|4175120:4231425|4175120_4176638_-|AYN40580.1|integrase|DBSCAN-SWA
MKGSTHRRCYCRDAETGKPLGKSCPKLSSRKHGSYSIRQELPPHEDGTRRSFSRAGYESLKDAQADLDHVRSLLALADKDDPDSLQRLVDMLEAVGTEKAPLPALEETRRRLRAGLALRGSLTVGEWLDQWFAAKKRRKTTLNGYASHIRVHLKPRIGHVRLDRLNVGHLVEMFDGIADDNEVIAAENGARREQIARCKPSKPGRPVGAERKLLAVERAKLAEMKPFRKITGPASRQAIRRTLRAALNSAIAQQLVTFNPASHVELESGKRPKPLLWTDERVRRWRETGEIPGPVMVWTPQQFGAFLDAAEGDRLYAIFHLMGTRGLRRGEAVGQDWHEIDLDAGLITPAKEIVVDGWDPYESEPKTDGSANTIALDSTTISELRDHKARQEKERAKWGEAWQDTGKVFTKEDGSWLHPGTVSETFRRILATTNLPPITLRDLRHVTATLTHGGGGDIHTVKETLRHSTITLTSDTYTSLLPELDREIAEKAASLVPRRPRNGAK
>CP033073|4175120:4231425|4187337_4188108_-|AYN40589.1|transposase|DBSCAN-SWA
MSGVITASEPSWIAPFTGLSPRQFGKLVTALRREGADPVRKGRPWSLPLEDRVLLVAAYWRTNLTLRQLAPLFGVSKSAADRIIDHLGPALALQQRKRFRKDTMLIVDGTLVPTRDHQVAEQSKNYRYSTNHQVVIDADTRLVVAVGRPLPGNRNDCKAWELSGTKDAVGHTTVIADGGYRGTGLVIPHRRQPGQADLPEWKEEHNASHRKVRARVEHAFARMKTWKILRDCRLKGDGVHHAMLGIARLYNLTLAG
>CP033073|4175120:4231425|4177416_4177647_+|AYN40582.1|DBSCAN-SWA
MRNDETDRESKGMTREELLTLPVAVDLDTGNRALGLGRSKGYALAKRGEYPCKVLRLGNAYRVVTADLLDLLGLAA
>CP033073|4175120:4231425|4226644_4227970_-|AYN40609.1|DBSCAN-SWA
MRANHRVRRIATVVGTVQTAALLLATPAFAEPSPSPSKSNDPCDLIRGPAKQYCEKGGGSSKGGKLGTNNPLTDTLDPLSSLGKGCAEAAAWTVGKLSKAVKETANVDFTNPKFLQQYAIVFAASTILTLLLWLLAVAKRAVRGVPLTTAISEAIGFLWLTVLASAFTPLILYTVVSATDGVTDVLAKATGDQTDTFFGTFSGALNKGTDIGGGPIMLIVVSLVSILAAGILWLELVIRAALLYVGALLGTVVYAGLVDKNLWGHVRRWAGIMIAVILVKPVIVIVLGLAGALSGADGPDAFSAVVSGLAIILLAIFASAMIYRFVPGFGDEIAGSRSNRIMQGAEGKAAAVISSPATLVAQGIKTHSTRADNNGGGGQSGSAPRPANPVSGGVAAHSSRTPSGSSGGAVPSAAPAPRAASPVNTPHASNTRNNRSGGEGR
>CP033073|4175120:4231425|4181101_4182457_+|AYN40585.1|DBSCAN-SWA
MAAQRRLNARLREVIEAIGCTYDALARDIRRIAAENGEILQTNKSAVSHWVNGTRQPTGRTDQYLAEALSRRAGRTITLAEIGLRTPENTVSEEPDPVLAVTDLGRADVERQRFLAVAAFTTAGVSMPLLYDQEATARMLRARTGGSLVGIEDVDVVRQITAAFSSADERLGGGHGLTTVAAYLADTAAPMLRGRFPNEALRQAAFGSVAELAYLAGWKHHDLGQEGAAQRYYQVGYQLACEADPRGHAAWMMRALAHQALSLKQPHHCVDLVEGALTRCLGHVDGQTEALLHITHARAYAAVGEKPAAARALLAAEDALLRDDAPQPSYSRVSGPAAGTVASHTARTLTDLADHVGTEQQHRDALMRWDPEKYKRVHALTYADLGDSLAAQARADEAVAAWSQALTLMEGMTSDRTRKAITSLRSTLAIYQRRKVPGAAELNRRAREALA
>CP033073|4175120:4231425|4198415_4199840_-|AYN40599.1|DBSCAN-SWA
MSREQRGPNEKLGAVLALAGISNAGLARRVNDLGAQRGLTLRYDKTSVARWVSKGMVPQGAAPHLIAAAIGQKLGRPVPLHEIGLADADPAPEVGLAFPRDVAQAVRSATELYRLDLAGRRSGAGGIWQSLAGSFAVSAYATPASRWLITPADSSVARETASAEESGAPIKVGHSDVQKLREAAEDARRWDSKYGGGDWRSSMVPECLRVEAAPLLLGSYSDEVGRALFGASAELTRLAGWMAFDTGQQEAAQRYYIQALRLARAAADVPLGGYVLASMSLQATYRGFGDEGVDLAQAALERNRGLATARTMSFFRLIEARAHARAGDAQAAGAALKAAEGWLERSREGDNDPSWLGFYGYDRFAADAAECYRDLKAPRQVRRFTEQALSKPTEEFVRSHGLRLVVSAVAELESGNLDAACEQGVRAVEVAGRISSARTTEYVKDLLHRLEPYGDEPRVVELRERARPLLVTPA
>CP033073|4175120:4231425|4230654_4231425_+|AYN43742.1|protease|DBSCAN-SWA
MSRISRISVTSRPALLGAVVMLALTSASVAAADDGPGPLGVTADAVATRQSARVGALFDADRAGRPAGGHFCTASVVHSPRGDLIVTAAHCVDGDDGDLVFAPGYRDGQAPFGMWKVMRRFLPDAWTSGQDEDSDLAFAAVAERDGERLEDVVGANRFAAGVATGATAVTVIGYPDSREAPVTCTDKPASRSDTQQRVECPDFTGGTSGSPWVNGDGQVVGVIGGHEQGGATADVSYSVVLGGEAAELYRDAMSAS
>CP033073|4175120:4231425|4185690_4186758_-|AYN40588.1|DBSCAN-SWA
MINEWWSHFPPDAQPSLRSRLRDRNSNANVFSAFWELYLHEMLLGSGCTVEIEQQIGTGGKNPDFLVTRDDEQFIVEAIWANQHLDATGSSSLPPQVADAIDRIPSPNFYVSYKVDSIGSTTPPQKRLKSELTGWLANLDPDLVTAEYEQKVPLPRHTWQEADWRLSFEAIPRSPGRRGDPASRTIGFHPSVWVADDSKRLLKAVRKKGGRYGDLALPFIVAVGNSAVFPEDEDIESALYGTSVEYAHRTGSTFGRNPDGYWTAAQEQAHSRVSGVLTVDNPAPWTWTKKVPVLWQSPTRGSLPAPVLPTWETAQLVDNHVERKPAARPIHTSLALPEHWPSGDAFPRRQPSTGS
>CP033073|4175120:4231425|4190297_4190816_-|AYN40592.1|DBSCAN-SWA
MTTRWLTPPEQRAWRAYLAASRLLEDAIDRQLQQEGSMPHLFYSVLANLSEAPGRRLRMTDLAETLKITRSRLTYVVTRLERDGLVRRESSGRDRRSSLAVLTDEGTAVLERTAPGHVETVRTTLFDRLTPEQVGQLEEICAGIARGLQGEDGGATAAEDVPWRRRSSPCAD
>CP033073|4175120:4231425|4196149_4196974_-|AYN40597.1|tRNA|DBSCAN-SWA
MADSLNTPDAPLSAPHDPGVSVRHTRTRGEPRFPDGPRADPAGSHFERRIRSFQPRRSRVTAGQADALQRLWATWGLDIDGQRVIDLGELFGNDRPVVLEIGFGMGEATARMAAADPDTNILAVDVHTPGQGNLLNLADRDGLSNVRVGNGDAIILLREMLRPDALDGLRVYFPDPWPKKRHHKRRLIQPEFLTLAATRLKPGAVVHCATDWEPYAEQMLEVLDAHPDFENTQAGGGFAARPAFRPLTRFEGQGLDKGHVVNDLLFRRVPHRGR
>CP033073|4175120:4231425|4176634_4177321_-|AYN40581.1|DBSCAN-SWA
MTQNDFDAGRDEDDVPEWADQVTATVAAEVRRRRKELRMSAQDLADKCEEIGYPIPRNVIANMESGRRSTLPLVEVMVLAEALQTYPICLLYPVGYVERVQRLPLRDDEATWDALHWFTGDSEGFGMEDDMLRAFRAHASHQRAALAALKGEKHERWKAETAPNQAEREEATLAQAAYAERALDAKYRLRSARALIRADGGTPPSLPPELADIDPPRSDANTNEENGF
>CP033073|4175120:4231425|4228961_4229270_-|AYN40611.1|DBSCAN-SWA
MLFAADKGDINTIIGGIAPDWGPFGSLGNEAKVMIEVVMAVAILLCLGLAVWGAAKQRIGATALRDTFSAEQGKGLIIAGLTGVFIIGSLGTLFTIVYGMAV
>CP033073|4175120:4231425|4208545_4209382_-|AYN40602.1|DBSCAN-SWA
MHVQDKHWASTATITPGGGSMTAAMGDGRADGARTTPLRVDAQRNLEHVLRAAREVFGELGYGAPMEDVARRARVGVGTVYRRFPSKDVLVRRIAQEETARLTEQARTALGQEDEPWSALSRFLRTSVASGAGRLLPPQVLRVGSAGPDESEASGGPAGSVGIVPPVEAVARVSSVSSAEETRMPQQRVQPGGGELRLVADEVSLTADDTGAGALLEVVGQLVERARAAGELRADVSVGDVLLVIATAAPSLPDAAQQAAASARLLDILLEGLRSRPV
>CP033073|4175120:4231425|4190893_4192027_+|AYN40593.1|DBSCAN-SWA
MPLPYVLLSAAVSLDGFLDDTGPERLLLSGPADFDRVDAVRASVDAILIGAGTIRADNPRLLVNSAERRAARVAAGRPAYPLKVTVTASGDLDPGAHFWHTGGDKLVCTTDAGAARAARLLGGTADVVALGPALDWRVLLEHLHDVRGVGRLMVEGGGQVHTQLLQQDLADELQLVLAPLLVGDPAAPRLFGPGAYQGGRLRLTDTRRIEDVVLMRYEPTAPGTGPVATPADRHWLRTACELAALCPPSQTAFSVGAVLVAADGTELARGHSREGADPVVHAEEAALAKTDPADPRLPGATVYSSLEPCARRASRPAPCAELILRAGVRRVVTAWREPDTFVAAADGTGVLTGAGARVVVLPELESLAKAPNAHLLA
>CP033073|4175120:4231425|4200565_4202641_+|AYN40600.1|DBSCAN-SWA
MRWLVGWSSTAAGTAGTGTAGATGYDGETLRPVGSQLLWGDPDPLWAVGDWRPDEVRVVHADPQHRIAVLGICGATDEELRRGLVTARGGALRHLTNWPGSYTAVVQAGRRITVCGDLAGVRPVFHTPWAGGTAYATAALPLADLVEANLDFTHLAALLAAPDVPAALRDTTPYEGVRRIPPGHALVLRAGAREIAGYEPVASLAVAAPASDPDRAVDAVRDALVDAVRTRLSAPRHVPDLDPGPVPGMGPAERRAARGMPVPGIGADLSGGPASGTLALLAAGLPGRPGTLLGHGTGAGERLLAVTFNDLAVAGREAELQRAGALAANPRLHHVVVTGGEETLPYAGLDGPLTDEPGPSLVLAARHRARLAAGSADHFTGHGARQVLDAHPARLADLLMDRRRRHLVRPVAALARADGSVLVPARVYGAARRLARTPYRAGLEVLAERLMRRRFDEPKGAVGASLAALTWAGPGPAARWLTGEALAEVSVLLQAEADRSGTGAQRPGDYRARAALARHAADLRVLEQAAEIRSQRLHAPFLDNQVVRACRDLPEALRVQPGARSAILRTVLAGSGVTDLPPGWGTPSHGSSAAAARAGLRVAADSLLDLFSSPLLADAGLIEARVVRKALRTAAAGEALPLDGLAGLVSLELWLHRLLGRRGTCWTGTPSRSRAVPSGIQPRRGALTPGA
>CP033073|4175120:4231425|4211271_4212918_+|AYN40604.1|DBSCAN-SWA
MNFTRWSARLPGTQRRAAARTKTPVPPDRRGEGSVPAARAERSADGTPPVPAVDELPAREVLDRVPALVALVHGPDHRIAYVNDAYTAAFGTRPTCAPAREALPELAQLGLFPLLDQVLRSGRPRTLKSRKAVDGRSYTFTCTPVAEDGDRGAGVLVFATDVTDHAEAAERLRASERRQRETAVTLQRSLLPQELEQPDDLRIAATYQPGGTEAAVGGDWYDVITLGGGRTALVIGDVMGRGVRAAAVMGQLRTAVRAYARLDLPPHEVLQLLDGLATEIDPHQIATCCYAVHDPSEGRLVYASAGHLPILVRDENGTVSRTDEPTGPPLGTGGWMHSSGSIALGPGATAVLYTDGLVERRDADLDEGIASLAGALAGATGTPQVVCDRLVRSAGVTADHDDDVAVLVLQHPARTGPDGDLFRNAALELLGGVEAAPRARAFASGVLTSWRFPTELHDLGVLAASELVANSLQHGTPPMRLRLRRTDRRLIVEVTDGDDHLPRRRRAEPGDESGRGIAIVATIATSWGCRRTPDGGKAVWCEFVLPKR
>CP033073|4175120:4231425|4227959_4228790_-|AYN40610.1|DBSCAN-SWA
MNPGDEQSYTDYGDTGHTRTRLPENDPYGGAPRRPHRSSSKSLVTVVGVVVLLIAAIAFANRGDDTPTDTATTKGSRPQTSSTAPSGTHPVGTRTTGIPSGFPRTEQGAQSAAANYAVVLGSADMFSAARRHEIVLAVYAPAIAAARQSALDSAYSNESFLSNIGLTKDGTPPRGQNFVSRVIPVGTKVTSMGADSAKVEVWYTSLFGLSGEASTNPVTESWFTTTYELKWVNDDWKVTDFQQKDGPVPVGRDQKASTADDMTKAVEEYGGFTYAR
>CP033073|4175120:4231425|4229615_4230377_-|AYN40612.1|DBSCAN-SWA
MTTMRTGTVQEAAGSPPPPPRAGRNRLVGAALLLSSLAAALTCHFVFTTWLPGDRALYREYEAAKACPARTVTPRSEDCLRKVTFTVEDTRKTPKYMRATLHGREPFPEMVVPFGDSGPVLSELERGDRVTATLWRGVVVVVAAGDDRQNSSDAPRDEPQMTAALGTFTGLLAALALLFGVMRLARPRGPGLFTWRPYGMWLCLVTVAACTVVGFLTVWAGLPWLLVPTVCGTVVAGTAWLLHRDLRHGRVGR
>CP033073|4175120:4231425|4209725_4211138_+|AYN40603.1|DBSCAN-SWA
MDKQLRRVRHGTVKERARILVVGGGYVGMYTALRLQRKLKGELRRGEVDITVVTPDPYMTYQPFLPEAAAGSISPRHVVVPLRRVLDRCHVVVGEVTSLDHATRTAAVSTLATAEEGRPAELLGYDELVLAPGSVSRTLPVPGLAEYGIGFKTVEEAIGLRNHVIEQMDIASSTRDPAIRDAALTFVFVGGGYAGVEALGELEDMARYTARYYHNIHPDDMKWILVEATDRILPEVGVEMGRYTVTELRRRNIQVLLDTRLESCAGRVAVLSDGQRFPTRTVVWTAGVRPHPLLAATGLPRTDRGRLRCTAQLTIDGTEHAWAAGDAAAVPDVTAAVPGAETAPNAQHAVRQARTLGDNIAHSLRGEPLETYAHKYVGSVASLGLHKGVAQVYGRRLKGYPAWLMHRVYHLSRVPTFNRKARVLAEWTLAGLFKREIVSLGSLEHPRAEFELAAGGKSPHDPSDDPKGSS
>CP033073|4175120:4231425|4180126_4180876_-|AYN40584.1|DBSCAN-SWA
MTTIDTTAITVELPEAFDERWSRLPGVQVDGRRITIDPAEYFFRFESNTWLVADWELVKAQLLDVQETTESAVEQLALDFIKAHAGSTSDATRVLATAYEVYAYLFRDEHLASLGLPQITADHLRMLREAATLMALNKVELDGHISNVGPCWFFPAATSVVFDLDDEMGGTLDEVYHGGWFNEHRRIESIKAHAALGGRLVHGCQSVPDQTGGVVAPYGASMSAFRDDLAAFKAGWIERVYAQRVSPAA
>CP033073|4175120:4231425|4188699_4189314_+|AYN40591.1|transposase|DBSCAN-SWA
MAAHQKGAVNTRAWIVFLDESGVSLLPQIRRTYSPRGRTPLLRHRLNWKRASMAGALGYHSTDPDRGARLCFHLKPGSYDTATLIEVLEQVKVFYRGERVVLVWDGLSAHWSRAMRAWVAEQDWLTLERLPAYAPELNPVELLWSSLKKRELANLAGDHLADVADATEQGIHRINANPRLPWSFLAHTGLTIRPPHPPNLRKNQ
>CP033073|4175120:4231425|4197103_4198315_-|AYN40598.1|DBSCAN-SWA
MVQVRAGAYDCDVLVIGGGIVGLSTAYAITRAAPGTRVTVLEKEPGPARHQTGRNSGVIHSGIYYRPGSLKARYAVRGAAEMVKFCAEYGIAHAVTGKLIVATGREELPRLHALVQRGRENGIPVRELGPAQISEYEPEVRGLAAIHVGTTGVCDFVGVARELARASGAEIRYGARVVRVDRRPERGVAVLTAAGDVVRARVLVNCAGLYCDEVARLTGDEPEVRIVPFRGEYYELARPELVRGLVYPVPDPAFPFLGVHLTRGIDGSVHIGPNAVPALAREGYGWGVVRPRELAGTLAWPGSWAIARRHWRYGAGELRRSVSRRAFLEAVRRLLPAVEAGDLVRAAAGVRAQAVLRDGTLVDDFLIKEGARTVHVLNAPSPAATASLPIGREVGRRALDLLA
>CP033073|4175120:4231425|4223661_4225077_-|AYN40607.1|DBSCAN-SWA
MRDPLSVLTDAFTSFLFGKVETTRLPVRTSTGQAQAVYLPTAAPGLGDSGVIIGREVYSGKGYIYDPFQLYGQQLPAPHWLVLGESGNGKSALEKTYVMRQLRFKDRQVVVLDAQGEDGVGEWNLIAEELGITPIRLDPTAALNHGIRLNPLDPAITTTGQLALLRTIIEVAMGHGLDERSGFALKVAHSYVNETILDRQPVLTDIVEQLRHPEPDSAEAMNVAIDDVRAWGLDVALVLDRLVDGDLRGMFDGPTTVGIDLDAPLIVFDLSHIDRNSIAMPILMAIVGVWLEHTWIRPDRKKRIFLVEEAWHIINSPFVAQLFQRLLKFGRRLGLSFVAVVHHLSDVVDGAAAKEAAAILKMASTRTIYAQKADEARATGRVLGLPRWAVEIIPTLTPGIAVWDVNGNVQVVKHLITETERPLVFTDRAMTQSSSDLAADEALRAAELEAEQRAAAFVEQQHLGDSESTVA
>CP033073|4175120:4231425|4182493_4182994_+|AYN40586.1|DBSCAN-SWA
MAQPTTDDQRKALKPALESMTLLVAAVIVHDKATNRVVLLQRSENAKFAQGMWDLPVGKSEPGEPITETAVRELYEETGLTVKPETLKVAHIIHGAWGVEAPNGFLTVVFAADEWTGEPENREPRKHAQVCWVDAEAIPEAFVDTTASALRRYLTGGSQVSLDGWR
>CP033073|4175120:4231425|4177873_4179160_+|AYN40583.1|DBSCAN-SWA
MQPTTPEPDSAPAEVVWPTAAVPGRPGYPPPEAAPATDDRAPDPVPADEPAEEAVPDPDSTYGSALLDELRARIAKFVILPSEQALDAVTLWVAATHLQPAWQHAPRLAVVGPAKRCGKSRLLDILTETVHEPMLTINTTPAAVFRSITDEPPTLLVDEADTIFGTPKMAEKNEEMRGLLNAGHQRNRYVTRVVGNDHTPHKFATFAMAALAGIGDLPDTIMDRSVVIRMRRRAEGESVKPFRSRRDTPALHDLRDRIAAWARPLLDEAADLEPAMPVEDRAADTWEPLVIVADLAVGSWPRRSREACARMVAAEVEVEEEQPGGARILADIRSVFVAQREVDSLSTDELLHHLRQNAESPWAEWGRSGLTARDLARMLNQFGIKPGNVRLADGTQRKGYMRNKFIDAWRRYCPTVHPVDTEPAAAVG
>CP033073|4175120:4231425|4225091_4226648_-|AYN40608.1|DBSCAN-SWA
MTTESHLSHPITPRRTYLIGRARPNAIVGRNRESGEIALIVIGAFLGMMCGLLVPVLPLRIVLLTGFPLLALAAVYVPYKRRTFYKWFEINRSYKRTVKRGPHYRSTVMEAGTGLDGREVEIGPPPGIGRINWLAAPFGPDEIAVLLHADRKTVTAAIEIEGPGVGLRDSEDQEALVDRFGTLLKHVANGDGFVTRIQMLARTLPADPDAHAKDVTQRGDDRSPDWLQRSYDQLQSMVSTSSEQHRAYLVACMHYTRDLAAEANAMARAVRAHGTKVDRDAGLAVVMARELTDICSRLQEADIRVRQPLGQGRLASLIHSMYDPDHPIDHIQAMTKRNAWPAELDAMEPTFLQAKTRESRTRAPWCHATAWVKEWPMTPVGVNFLAPLLVHTPDVIRTVAVTMDLEPTEVAIERMLTEKTNDEAEASRAAKMNRTVDPRDIAAHNRLDQRGEDLASGAAGVNLVGYITVSSRSPEALARDKRTIRASAGKSYLKLEWCDREHHRAFVNTLPFATGIRR
>CP033073|4175120:4231425|4202961_4206285_+|AYN40601.1|DBSCAN-SWA
MTRAADDQGTPLPIGGPRLRTLLAALALRPGRTTTPDTLIGEIWADAPPQDAPAALQALVGRLRRTLGRHAVTYAPGGYRLEATEDDVDLHVFERLTRVGTHALTAGDPATAHRTLTEALALWHGPALADLPDRTAAARPDALRLDAARARAAAALALGRAQEAVPELRELATAHPYDEPLHALLIRALRDTGRPADALTAYESVRRTLADTLGTDPGPELRSLHTALLQQENPARSVDPAHPMPPAHPAPPVHPEVPHRARPPRRTGNLRPRLTSFVGREPELEAIRSDVHRARLVTLTGPGGSGKTRLAEEAAAAFPSAWLAELAPLDRPEAVPGAVVSALGMRETVLLGNELATPQADPTALLVEYCAPRSQLLILDNCEHVIGAAATLAETLLTHCPGLTVLATSREPLGVPGESVRPVEPLVPEQAHHLFAERAKAVRPDADTVLGDTAAVTEICRRLDGLPLAIELAAARLRLLTPRQIADRLDDRFRLLTSGSRTVLPRQQTLRAVVDWSWDLLDERERTVLREVSVFAGGWDLAAAEAVCTGPVAELLGALVDKSLVVAAPHDPDGTASGMRYRMLETIHEYATERAAEVPGLREAAERRHRAWVRALVEEAEPRLRSAAQLPWISRLETELDNVRAALDRAVRAGDEAGAGAVVLAIGWFWWLRNHRQEAVRWVRLVLRLGVALDAVSAGAPDGGLMALVESADPVGAFLAAPDGEAGHPLHELRTDLRMLDLFLTSDSRAENLTADDRAPEYVARVRAAYEPGGPRAARLPGLVWPLTAHYLGAPADVHPDLTQAVANCRRHGGAWEVGVALMFRTHVTVDSPGNLEGVDEDLAELRQLSRRVGDRWMRAQVCGAAGEAAMARGRFDAARAEYEEALRLAYEVGAYAESPFLLARLAEISYRSGDRKAALAALDEAETAADRYVVPESRAFVMLLRAHIALQDGCAARARELYEATCAVVRGSTRPPQFVAAQRTVEALLTADESGPAHGLPIVAQALREAVEQGGAESITAGLVDIAAGLLARLGDLPSALRLFAAADHWRDGRPRPEPERGVAARVRAGARAALPADRYAAESARGASLGVADVLRELGVPAAVE
>CP033073|4175120:4231425|4184923_4185319_+|AYN40587.1|DBSCAN-SWA
MPIRRQPDPIPNGPNFGIVNNGHMSGPAQAAPFSQNATQTNNITNEAVERARESIDDLRRRLEELRGRYPEVDAALRDLGMIAPRLDEPERDPGTLRYMLQNLVERCGGIPGVLAAAQLVQSTVMALLPGS
>CP033073|4175120:4231425|4214383_4214932_+|AYN40605.1|DBSCAN-SWA
MADTPGVAEPTLEEQIAAYQREFQDLDPQVEKIVSALSRLNRRMNVAYGRQTAALGISNAEWEVLKALVLSGVPYRMGPGELAKRLGLTPAAMTHRIDRMVAEGLVTRDRDESNRVRVIVELTPGGREKWLEAMRMATVFEEELLQDLTPVERVVLGEVLTRLLRRVEHAQPDAGGRLSDLD
>CP033073|4175120:4231425|4188211_4188727_+|AYN40590.1|transposase|DBSCAN-SWA
MAYQPSPSVAGSCLPPLSRPQLAEARRVRAVELFEGGVSNAEIAGAVGVCAESVRRWRRVWEQDGASGLRRRAATGRPPKLDDTQVEIVRAALEQGAQAHGFEADLWTLERVGAVVTRATGVVLSRASVWRLLTGRLGWSLQRPERRAVERNESEIARWIAHEWPRIKKGP
>CP033073|4175120:4231425|4192622_4193687_+|AYN40594.1|DBSCAN-SWA
MASNRPAPETPFVPAQRETETFGYDAHRADEGPWEEWNPTEDSVAPVRGRHRVAKQRGGFARSSTVLGVGVIAAVGAGGMASANTGKPPVSISLPDLPSVGSLFGDTSTEAPRTATTALSSVGVASADDQQGTDAGEALRNRILAQAEQQQGQADSRATAVALATAERQSAQAAAHAEEEAAAKAAEAKDAAEAAAAKKAERKAAKEAEEKRQAELAKLAGQYTLPTSSYTITSTFGQAGTMWSSGHHTGLDFAAPTGTLIKAVHGGTVTEAGWAGAYGYRTILTLDDGTELWFCHQSSINVTAGQKVTTGEVIGRVGATGNVTGPHLHLEVHPGGQATGIDPMTWLRDKGLTP

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
4173407:4173430	attL	NA	NA	NA	NA
AYN40580.1|4175120_4176638_-|integrase	site-specific integrase	A0A2P0ZL94	Lactobacillus_phage	1.8e-14	31.3
AYN40581.1|4176634_4177321_-	XRE family transcriptional regulator	NA	NA	NA	NA
AYN40582.1|4177416_4177647_+	hypothetical protein	NA	NA	NA	NA
AYN40583.1|4177873_4179160_+	DUF3631 domain-containing protein	NA	NA	NA	NA
AYN40584.1|4180126_4180876_-	hypothetical protein	NA	NA	NA	NA
AYN40585.1|4181101_4182457_+	tetratricopeptide repeat protein	K4IBI5	Streptomyces_phage	3.6e-27	30.8
AYN40586.1|4182493_4182994_+	NUDIX domain-containing protein	NA	NA	NA	NA
AYN40587.1|4184923_4185319_+	hypothetical protein	NA	NA	NA	NA
AYN40588.1|4185690_4186758_-	hypothetical protein	NA	NA	NA	NA
AYN40589.1|4187337_4188108_-|transposase	IS5/IS1182 family transposase	NA	NA	NA	NA
AYN40590.1|4188211_4188727_+|transposase	transposase	NA	NA	NA	NA
AYN40591.1|4188699_4189314_+|transposase	IS630 family transposase	NA	NA	NA	NA
AYN40592.1|4190297_4190816_-	MarR family transcriptional regulator	NA	NA	NA	NA
4189623:4189646	attR	NA	NA	NA	NA
AYN40593.1|4190893_4192027_+	5-amino-6-(5-phosphoribosylamino)uracil reductase	NA	NA	NA	NA
AYN40594.1|4192622_4193687_+	M23 family metallopeptidase	V5R8R0	Arthrobacter_phage	1.1e-18	47.2
AYN40595.1|4193768_4194722_+	aldo/keto reductase	NA	NA	NA	NA
AYN40596.1|4194776_4196081_-|protease	protease PrsW	NA	NA	NA	NA
AYN40597.1|4196149_4196974_-|tRNA	tRNA (guanosine(46)-N7)-methyltransferase TrmB	NA	NA	NA	NA
AYN40598.1|4197103_4198315_-	L-2-hydroxyglutarate oxidase	NA	NA	NA	NA
AYN40599.1|4198415_4199840_-	MFS transporter	NA	NA	NA	NA
AYN40600.1|4200565_4202641_+	asparagine synthase	NA	NA	NA	NA
AYN40601.1|4202961_4206285_+	AfsR/SARP family transcriptional regulator	NA	NA	NA	NA
AYN40602.1|4208545_4209382_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
AYN40603.1|4209725_4211138_+	NAD(P)/FAD-dependent oxidoreductase	NA	NA	NA	NA
AYN40604.1|4211271_4212918_+	PAS sensor protein	NA	NA	NA	NA
AYN43741.1|4212996_4214292_-	MFS transporter	NA	NA	NA	NA
AYN40605.1|4214383_4214932_+	MarR family transcriptional regulator	NA	NA	NA	NA
AYN40606.1|4220808_4221357_-	isochorismatase family protein	NA	NA	NA	NA
AYN40607.1|4223661_4225077_-	ATP/GTP-binding protein	NA	NA	NA	NA
AYN40608.1|4225091_4226648_-	hypothetical protein	NA	NA	NA	NA
AYN40609.1|4226644_4227970_-	hypothetical protein	NA	NA	NA	NA
AYN40610.1|4227959_4228790_-	hypothetical protein	NA	NA	NA	NA
AYN40611.1|4228961_4229270_-	hypothetical protein	NA	NA	NA	NA
AYN40612.1|4229615_4230377_-	hypothetical protein	NA	NA	NA	NA
AYN43742.1|4230654_4231425_+|protease	serine protease	NA	NA	NA	NA

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>CP033073|7900224:7954363|DBSCAN-SWA
GTCATGGGCCCTCCTGAGGTTCGGACAGGTGCAGGCGGGGGACGCTGCGGTCGGCGTCGGCCCAGGCGAGGACCGGCCGGCCGGGGAACTCGGGCGGATTGGCCTGGGCGTTGGCCCGGTAGTCGTGAACTCCGTCGGGCAACTCCCGGGTGGCAACCCGGGACATGTGCCGGACGCTGTGCGACGGGCCGTCCTCGCGCCGGTCCCACATCACCACAGGTATGCCCAGCGCCAGGCACGTCTGCACGATGCGGTCTCGGGGAGGGCCGGGTGGTACGTCCACGGAGACGCGTACCGTGTCGAGTTGGTTGACGAGCCGGGAGTACAGCGTGTCCCGGTCCGTGGGTTCGGAGACCACGAGCGCCCTGCCCGAGTCCAGGCGGCTCCATCTGCTGCGCCAGCGGGAGACGAAGCGCCCATTGCGGCGCAGCAGTTCGGGGCAGTGTACGACCAGCGGGAACTCCACCCCGAGCACGCCGGGCACCAGCTCGGCCGGATGGTCCCCGGCCGTCCACTCGTCGACGGGCAGGTTGAGGCCGCCGCGGTCCACGAGCACCTCCACCAGGGGTGGCCGCTCGTCCTCGGCCGGAGGGGTGAGCGAGTCCAGCACGCCCAGCACCTGGCGTGCCGCCTCCGAGGTCGAGTACGGCTTCACGCTCTCTGTGGAGACCTGCCGGGGCCCGGCCCCCTCGTCACACCAGATCCGCAGCCGGTGCCGGTCGCGCCCGGCGTTGGCCACCTGGACCAGGACCCGCACGCGTGTGGCCCGCACGCGCGCCGACCGCGCCCACTCCTGGGCGTCGAAGCGCCGTTCACCGAGGGCCGACCGCTCGATGCCCAGCCGTCGGGCCACCCCGTCCGCCCACAACCGTAGCTGCGCCCGCCGGGTGTCGGGGCACAGGGCACCGACGTACTCCACCACCCGCAGCAGAGCGGGCACCCGGCGCTCGTCGGCGTTCGCGTGACCGTCCCCCGGGAGGGTCTCCAGATGATCGAGCAGCGCGTCCACGGTCTCGCCGCCGGGCCGGGCCGCCAGGTGCGGCAACGCGGCGCGGACCACCTCGGGGAACCGCTCCAGCACAGTCGGGGAGAGAGCGCGCAGGTGTCCGCACAACTCCTTGTACTCGGCCGAGGTCAGCAGCCGTGGTGTGCGGGACAGGGCACCGGCGGCCAGGACCCGTTCGGCGCCCCGTGGATCGTCCCGGCGCAGAATGGCGGTGAGCGCGGGCATGGCGCGCGGACGCGTCAGCACGAAGGCGGTGAACTCCTCCGGCGTGGGTGGCACGACGTCACTGCCGGGCTCCACCCCGCACAGCCGGGCCAGCCGACGGGCGCAGTCACCCCGTCCGCTCGGCGAGGGCAGCAGGTCCTCGATCACTCCGAGCAGCACCTCGAAAGCGGGATCGTCCGGCTCGACCGGCGAGGGCCGGATGCCGTCCAACACCCCGAGAGAGCCCAGTTCGGCCTCGACGGCCTGCCAGGGCACGGCCCAGCTACGCCGGATGACGCCCTGGAAACCCAGTTCGAGTGGCGCTCCGGCGTCGTCCACGGGCATGAAGTGCCCGACGACCAGCCCGACCACGGCCTGCTCCTCCCGGCACCACAAGGGGCTGCCGCTGTAACCGGGGCCGACCGCCATGCCGGTGGAGGCGCCGTCCAGGTAGGCCAGGCGGCCGTGCAGCCCGGAGACGGTGAGCCGGGCGATGGTGGAGGCACGGCCCCCGCCGTGCCAGGCCTCCGCCTTCTGGCCGGCCGTCATGGCGGCCTGGCGGGGCGGGGGCGGTAACCCGCCGGCCGGGGCATCCACGCGCAGTACCGCGAGGTCGCCGAGCCACTCGTCGGCGCCTGCCGTCACCGGCCCGCCGCCCCGGGCGCGGGGCGGGATCCAGTGGGCCACGCGGGAGGAGAGCCGCCGGCCCCGCACCATGTCGTCGTCGCGCACCTCCACCGGAACCTCGCCGACACCCGGCGGCCGTGTGTCGAACATGTCCCTGCCCAGAGCGACGTTGACGACATGCGCGCAGGTCAGCACCGTGTCGGGGCCCAGGACGAAGCCCGCCCCGGCGGGCTTGCCGTCCTCGGTCCGCCGGACGGTCACGACATGGCGGGAGGGATCGTCGGAGCTGTCCCACCGGTTACGGAACCACCCCACGCGTCACTCCGCGCCGGGCGTCGCGCCGGCGTCCGCGCCCGGCTTCCAGCTGGCCGTGACGGTGAGATGCGCCTGCCCGGCCGCGCCGACGATCCCGAACTTGAGGTCGTGCCCGACCTGCACGCCGAAGGTGACGCTCAGCTCGGTGGGTGGCTCGGGCACCGCCGTCGCCACGTTGTGGACCTCCTGCAACAGCGGCCCGATGGGGCGCAGGGCGGCGCGCAGCGCGTCGGCCGCGAAGTTCGCGACCGCTCGGCTGCCGGCCCCGACCGGCACGGCCCGGCCCATCCCTTCGGGAAGGTCATCGTCCACGGCGGAAGGCACCGCACCCGCGACAGACGTCAGCAGGAAACGGACCGGAGTGCCGTCGGAGAGCGCGAGATCGGGTGAAGTCGACACGTCATCAGTATCGGCCCGAACCTCACACGGAACGCGAGCTTTGCCTGACTCGGTTACCCAAACGATGCTTTGGGACCTCGGGAGTCACGCCCGACTCAAAGCGCGACCCGGGCCGAGCAGGGCGCCGCCGCCCTGCCCCGCCGCCCGGGCCACCCGCTCCGGCGGGTCGGCCGCCACGATCCGGCCGCCCCCGCCCGACCCCAGGCCGATCACCCGGCCGGCAGCCGAGGACCACCTCGTCGCCGGACGCGCCGCCGGCCACTCGAGCGGCCCTGGCGCCCTGCTCCTGGCCGGGTACCTGCTCACCCGCCCCCGTCCTCAACCCCCTGGTACGACGCCGCGGTTCGTCGGCACGCCCGGGGCCCTGGCCCGGGCCCCGAGTCGGCGCCGCGTCCCCATGGTCAGGACGAGCTTCGCGCACTGGCCAGGTCGCGTCAGCTCAGCGTGGACGACCACATGTTCACCCTCCCGGGGCTGCAGTGCTCCCCGCGCAGCCGGGGCGGCGCGTACCGCGCCTCATCTGGTGTGCTTCTGGTGCTCCCTGCCGCCCTGCGACTTCCTGGGACGCCTCGACGACGACCTGCTGACCTTCAGCGGCGATCGGCTGGAGGACGACATCGCGGCGCTCACCGTCTGCGTGTCGCCGGTACCGCCCCGTCACCGGCCGGATGAGCACCGCCGGGCGGTGACCGCGCAGGGCACCCGTACGGTGCTCCGGCAGGCCGTCCGGATCAGAAGGCCGTGTGGTCGAACCAGCGGTCGAGGACCGTGGCGTCCCCCGAGACGTCGAAGACCGTCTCCTGGTACGACCGTCGGCCGTAGAGCAGCAGCAGAAGGTCCGCCGCCTGCCCCCGCACCGCCGCCGTGTCCGGCCCGGACTCGGCAACCCCGCCGGACAGCAGCCGGATACCGACCGGCTCCAGCCGCACCCGCCATTCCTCACCGGCCGCACCCGTGCACCGGAACGCGATCGTCTCGCCGTCGCCGCGCAGCTTCGTCACCGCAGGCGCGAAAAGCCCCGCGTACGGCAGGTTCGCCAAGAACTCGTCCACTCCGTCCGCCGCCAACACCGGGTCGACGGCCGTCTCCCGGCCGACGGCACGCTCCGCGTCCACCCGGTGCACCAGCGTCTCGAACAGCATCCGGCGCGCCCAGAACCGCGCATGCCGGTCCTCGCCCCATGTCCACATCGGCGCGTCGGGGGCTGTGTCCCGCAGCACGGCCGCCACGTCGGGCACCCCAGCCGTCACCCAGTCGGGGTAGTCCCGCGGGTCGTCGGGCAGCCCCAGCTCCACGTCCCGGCTGCGGGGAAACTCCTGCACGCGCCGGGACAGCAGGGTGCAGAACCAGCGCTGCAGCGAGCCCACGTGCCGGGCGAGCTCAGCCAGTGTCCAGTCGGGGCAGGAGGGCACGGCACCCGCGGGGTCGGCGCCGCGCACCGCGTCGGCGAACCGGCGGGTCTCCCGCTCGATCTCCTCACGGTAGGTGTCGTACGGCAGGGGATGTCCCGCGTTGCTCGTCGTCGCCATCTGCTGCCGCCGTTCTGTCACGGGTACGGATTCGGGTGACGACCAGTGTGGCGGCTGGAGTGCACTCCAAGGCAAGTCGGCCTCGGGTGCATCACCGAGCGCAGGCCGCGCCCCGGCCGGCGCGCGGCTGGGTGCGTTGGCCCGGCCGTGAATGTGCCGGTGCTTGCCGTGCTCACCGGCTCCCCTTGGCGGTGTCACGGGGCGGCCGACTGGGTTCCCTGGAACGATAGGGAGGTTGAGACGTGGGGCAGGCTCGTTGAGCGCTGGCAGGTGGTGGTGTTGAGCCAGTACACAGGGCGGTGTCCATCTCTCGTGGGGTCCAGTCGCGGATCGGGGCGGGGCTGCGGCCAGGAGCTGGTCGATCGTTCGGCTGTAGCGGCTGTAGCGGCTGTAGCGGCTGTAGCGGCTGTAGCGGCTGTAGCGGCTGTAGCGGCTGTAGCGACCGGGCGCGTGGGTGAGGGTGATGCCGAGGGTGTGCAGTGCGCTGTGGGCTCGTCGGTCGTAGATGGCCATGCGGTCCGGTGCGGCTGCGGTGAGGACGGCGAAGGCGAGGGCGTCGCCGGTGCGGAAGCCCGGTGGTGCGGCGAGGGCTGCTCCGCCGGCTCGTGCTGAGGTGCTGTGGCTGAGGGAGGTGTCCCGGGCGGCGGTCGTGGCTGTGGCGGTTGTGCGGCGTACGTCGGCGCCCGGGAGGGCCATGAGTTCGGCGGCCCAGGTGACGTGGGGCGCCTACGGGCGACGGGCGGAACACCCCCGTGTCGGCGGGGAGGACTCTTTCTGAGCTGTGGTTCATGCCGGCGGCATGCGGGTCGGTCAGCAGGAGGACACAGGACAGGCACTGGGCCCGAGATCAGGTGGTAGCGACATGCGCGCGAGTCCTGCGGGAGTCCTCGGGTGTCCTCGTGGATCTCAGCGAGATGGATGTCGGTCGCCCCGACCCCTCCCGCAAAGCGTGGTACTCCCAACGACCATCGACTGGCGGCCTTGGACGAGGCCCTGAGCATGGTGAACCTCGTCGCCGATAGGGACATCGCAGAAGCCGCACACGCCCTTGACGAGCAGATATGGCGCTTCCACATCCTCGTCAGACGGGGCCTGACTCCAGAGGACAACTGGCTCGTTCTGCGCGGGCGCGTGGTAGCAGCGCAGAACGACTTCATCACCGTGGCACGCCGCTAGCTGTCGCTGGCCGGAGATCCGCTTCAGCGCTTCTCCGGGCGGCCTGCTCCGGCTGATCCGGTCTGGACCTCTTGAGGGCTCACCCTCCGGATACGACTATCGCGCTTTGGCTCATGCGCACATCGCCGGGGCGCCGGATAGCCGGGCCGCCACAGCTTGCGGTCGGAGCTGACGGCCGTGGCGCTCACCCCGCCGGGCCGCCGGCCGGAGCCGACCCCCGGCTCGGCGGACGACTGGCTGCGCGCGGCGTTGGAACGGGACGACTCCGGTGAGTGAGGGGCGTGGTCCTCGTCGCGGCCGTCACGGTGATCGGATCCCGGACACCGGGCCCGCGTTCTCACATCCTGGTCATACCGCTACCGGTGAGGCCCGGTGCCACCGCCGGGACCCAGAAGACGACGGCAGCCAGGGCGATCGAGGCGATGCCCACGGCGCGGGCCACGAGACGGCCGCCCGGAGCCAGCTTCTCCGTGGTGATCACGCCCGTCAGGACCACCATGGCCCACAGGTTCATTACACCGAACACGGCCAGGAGCACCATCAGCGACCAGCAGCAGCCCAGGCAGAAGGCTCCGTGATGGCCTCCGGCACGCACATCACGCGAGCGCCCCGGATACGAGGTGTAGCGCAGCACCAGCCAGATCGGCGAGCGGCATCGGGCCAGGCAGCGGTCTTTGAGTGGCGTGAGTTGGTAGGCGCCGTTGATCGCGAACACGGCCGCGGCCACCACGGTCCCCGCTCCGGCGGGAAGGTGCCCGGCCCGGCCCAGGCCGACGGCCAGCCCGTACGCCGGCAACCCGGCCGCAGCCCAGACGAGCAGATAGGCCACCGTGAAAGCCGCCATGCGCGGCGCCCGGCGCACGGTCATGGTGCGTGCGTACAGCGCGGCGACGAGGGCCGTGGCGGGCAGCATCATCGCCGCCATCATCAGCGTCCACACAGCCAGAAAGGCGGGCAGCCCCAGGCCCATGGTGCCCGGAACCATCTGCATACCGCCTTGACGCGTCACCACCCAGACCCAGGCGGCAGCCGACGCGACCAGCAGCAGTCCGGCGGGGGCCGCCTTGCGGCGGACAGTGATCAGCCGACCGGTCACGCGGACCAGCTAAAAGGCGCGGAGTGCCCGTTGCCGCCGGAGAAGTCCCAGGTCCGGCCGTACACGCCGTCGCCCGTCGCCCGGGTGGACCGGGCAATGGTCAGCGTGCTGTTCGCCGGGTGGAACATGCCGGTGAGGCTCATGACCGGACCGTCCTCGCCGAACTGCGGGGCGACCTGGTCTTCGATCTCGATGTCGATGGCGTCGCCCACCTGCGCGGCGTGACGGCGGCCGTCGTCGCGGTAGGTGATGGGAACCCGCTCCACGCCGAGGACATCGCCGATGAGCGGAGTGAGCGCCGCCATCGGCCCGCCGGCTCGGCCGGAGAAGACCTTGCCCAGGGACTCCGCCTGGCCGTCGTCGGCCGAGGCGTCGAGGTAGAGAGCCACCTGCCAGTCGCCCTCGGCCATCACCCGGGGCGCGTCGATGAAGACGGCGACGCTGCGGTCGGAGACGTCCACGCCGTCCACGTTCCCGCTCTCCACGTGGAACGCCAAGGTCACCTGGCAGCGCTCGTGGTCGGCCGGTGCGGTCAGGCCCGAGGTGGTGCAGGGGCACACCGCGTCGCAGTTGCAGCTCTCCAGGTACGTGCCGTTCATGTTCCAGGGCATGGCTCTTCGTCTCCCTCTTCACCCCTTCGGGGAAACCGATGCATCGGGAGGGTCCGTTCGGTCCCGGATCCGCTCTTCTCCAGGCTATTCCTGACGCGCCGGGGGCGCAGATGGCTGCCGGTGATGGGCGTGGGCCGGCGAACGTCGACGCCTGCCAGGGCAGTGGGCCTGTCGAGTCCAAGTGGCCGCCGGTCGGGCCGTCCGGTCCCAGTCGAGCCACCGAACGATGATCTCGGCGCCCTGCTCGACGGTCGGCACGCCCTGGTGCCGGTTCAGGGCCGTCGCGGTGTAGCCGGGCTCCACGGCGTTGATCCGCATCCGCGGGAACGCCTTGGCGAACTGCACGGTGAGCATGTTCACCGCGGTTTCGGAGGCCGGGTGGGCGACTCCGAGATACCCGCTGCCGGCCCGGGCGAACGAGGCCAGGCCGCTGCTGACATTGACCATGACCGGGGCGGCGGAGCGTTCCAGCAGCGGCAGGAAGGCGTGGGTCACCCGGACCAGGCCGAAGACGTTGGTCTTGAACACCTCCGCATCACGTCGGCGGTCAACTCCGCGGCGCCGATGATGTCGCCCCCCGGGGACCGCGCCCCGATACCGGCGTTGTCGATGAGGACGTCCAGGCCTCCGTCGGCCTGAACGAACCGGGCGCCGAGCTCGGGCGCGGCGACCGAGCCCCGCTCGATGCTGCGCGAACCCAGGTAGACGGGTGTGACCCATGGCGATCAGGCGGCGAGCGGTCTCGTGACCGAGGCCCTTGTCGGCCCCGGTGATCAAGGTTGTCGCCATGGGGCGGAGCTTCCCTCCGGGATGACGCGATCGACCACCGGAGTACGACGCGGCGCGCGACCTTGTTTCGACCGGGGCGCCGAGGCCCGCCGTGCCGCTTCACTGGTCCCGGACCGCTCCGTCCTTCGCCGCCGCCTCGGGGGACCTGTCCTCCTGGGCGTGCCGGGCGGCATTCCTTCCGAGCGCGGTCCCGGAATTGATGCATGCCAGCCGTAGATCAGTGATGCGCCACCGAACTCATCGTCCTCACGGCCAGGCCCCCTCGCGCAGGGGAGGCCGACCTGATCGTGGCCCAGCACCGCAACGGCCCCACCGCCACGATCGAGGCCAGCTTCCAGGGCGCCGCTACTGTCGGATTCCCACTCGTTCTCGTCCGTGCTGTCCGATGCTCTTTCGTGACCTCTGAACGGCTGCCCGCTCGCACTCCAGTGGCTGATCAAGGCTCCCGCGGATCGGAAGTCGGGTGCGTACGAGCTGGTTCGCACTCGTATACTCGTGCGAACTCATGGAGGGGGGGTGGGGACAGTGAAGCTTGCTGAGGCACTGGCAGAACGCGCGGAGGCGACACGCCGTGTAGAACAGCTGCGAGCACGCGTCGTCAGCAGTGCGCGCTACCAGGAGGGGGAGACACCCGCCGAGGATGCAGCTCAGCTATTGGCCGAGGCTGGTGAGGTGCTGAACGCTCTGGAAACGCTGATCCGGCGAATCAACCGGACCAATGCCACCGTGGAGATGGGTCCGGACGGCCCGCTCACCGATGCCCTCGCACGCCGGGACGTCCTGCGGTCGCGTCACTCCGTGGTCACCGCAGCGGCGGACGCGGCGGCCGGTCAGGGCGAGCGGGGATACGGCCGGCAGCTTCGGTCCGAGTTGATGATGCTTTCCGCGCTTCCGGTCGCGGAACTGCGCGGTCAGGCGGATGCACTTGCCCGAGAGATCCGCGAGGTCGATGTACGGATCCAGCGTACGAACTGGGAGGTCGATCTGCTGGACTGAGCAGTCCAGTAGGCTGGGACGATGTGGAGCAGGTAGCAGCTTCGGAGGCGTGCACACACACCGAGGGCTGGCGGTTTTCCAGCCCACTCCTGGCGCGTGAAGAGCAACGCGGGGGTTCGACTCCCCATCAACAGTGCAGCTCAGCACCGCGTACAGGTAAAGGTGCACATCGCACAGCACATCACCACGTGCAGATCCGAGGCGGCGAGGGCGGGTCCGGGGCTTTCCACATCGCAGCACCATGGAGAACGGCGATCTTCGGCGGATACTGTTGGCGATTCGGTGGCGCTCCTGTCATCTATCGTCGAACGAGACTTCCGCGAGCCGAGTCATATGAGAACGCTGGCCACAGGTGGTGTCGAACGATCTGGCAACCACGCTGGTCAGCAACCCACCACACGCCGAACGCAGTGCGACAGGACAGCAGGTCGCGCCTGTATCTCGTTCGCGTTGAAACGCCGACGCCTGGAAGGCCAAGTGGCCGCCCGCTCCGCCAGGATCCGGGCCCCAGGATCGCGGCACGCCCGCCGCACACTCGGATCAACACGTATTTCTGCAGGAGGACTCTTTCATGGCTGACCGGCCCTTGACGCTCATGGCAGTACACGCCCACCCCGATGACGAGGCCACCGGAACCGGAGGGGTTCTCGCGCGGTACGCGGCGGAAGGCATCCGCACGGTACTCGTGACGTGTACCGACGGCGGTTGTGGTGACGGACCGGGGGGTGTCAAGCCGGGTGATCCCGGGCACGATCCGGCGGCGGTCGCGTTGATGCGTCGTAAAGAACTCGAGGCGAGCTGTGACGTGCTGAAGGTCAGCGATCTGGAGATGCTGGACTATGCCGACTCCGGGATGGTGGGCTGGCCGAGCAACGACGCCCCCGGGTCCTTCTGGCAGACCCCCGTGCAGGAAGGCGCGACCCGACTGGCGGAACTCATGCGGTACTACCGACCTGATGTGGTCGTCACCTACGACGAGAACGGTTTCTACGGTCACCCCGACCACATTCAGGCCCATCGCATCACGATGGCGGCGCTGGAGATGACCGCGCTGGCACCGAAGGTGTACTGGACCACGATGCCCCGCTCGATGATGCGGCGGTTCGGCGAGATCATGCGCGAGTTTCATGAGGACATGCCGGAGCCGGATCCTGCCGAGGCCGCCGCGATGGCCGAGATCGGCCTCCCCGACGATGAGATCACCACGTGGGTGGACACCATCGCGTTCAGCGGTCAGAAGTTCGACGCGTTGGCCGCGCACGCCAGTCAGGGCGAGAACATCTTCTTCCTCAAGATGGGCAAGGAGAGGTTCGGCGAGTTGATGGGCATGGAGACCTTCGTACGCGTCCAGGACGCCACCGGTGCGGCCGTACCCGAGAACGATCTCTTCGCCGGGCTGCGCTGATCCGCCCGTCCGACCGGCCGGGAAAGCTCATCGACCGCCCGGCGCGATCGAGCGGGTCACACACCCGGAGGCCTGTCCAAGCGAGTTGCGCTCCGCAGCCCGCTTCCAGGCCCTCGCCGGCGGCGTCGACGCGTGCCCGCACTTCCGACCCGACACCGCGCTCAACCCCAAAAACACCTGGCTCCCTCACAAGGGCTCGTTGGGGTCCCGGAGCGCTCCCAGAGCGGTGACCTTGCACTGGAAGAGGAAGAAGGGGCCGCCGAGCCGGCACAGGAACGCCGGGTGCTCGGAGAGCGCGAGCGTGCGCTGACGGAAGCGCCGGCCTGTCCCGTGCCGGGCGCGCGGCACACCGGCGGGGTTGATCTCCCACTCGGTCAAGTGCTCGACAACGGCGGCGAGAAGCTGTTCCTCTTGCCTGTCACGTCCGGACATTCACCACCGCCCGCGCGGTGGTGGACGTCGGCGAGGACGTGGTGACGCTGTCCGCCGCCGCGAGCATGTTCGAGTTCGCCCTCGCAGCGGAGGCAGTGCTGCGCCCGCTGGTCGCCGGCCGCACCGTGGACCTCGCCGGACTCGCGGAAACAGCCGGCCTGGATGTCGAGGACGTCGCCGTGCTGCTCCAGGAGCTCGTCGCCGGGCAGGCCCCGACGGTGGGGAGCCTGCTGTGACAGCGGAGCTCGGTCTGGGCACCTACCGGTGTTGGGCGATCCCGGAGGCGGCCGTCCGTGCGGCCGCCTCCGCCGTGCGGTGGATCGACACCGCCCCCGACTACGGCCCTCGGCATCGACGCCGCGAACGCCGGTGTCCTCACCGAGGACCAGACCCGTGCCGGGCACAGCCTCGTCCCGGAGCACGTGCGCCGGCGGATACGCCGCAACCGTGAGCAGCTCGCGCGCGAGTGGCTGGACCTGGTCCTGCCGCACAACCCCGAGCGGGCCCATCCGGCGACCGTCCTGCCCTGCACTGTGCGATCCGGGACGCTTGTGGAGGAGGAAGTGGGGGCCGGGCGCGTGCCCTTCACGGCCGTGGCCCGCTCCCGGACGAAGCCGACGTGGAGCTGCGGGGGATGGCCTCCGCGCCGCTGCACGGCGGCGAGCTCCCTGGCACGGCCGGCCAGGAGCCCGCCGACCTCATCCGGCCGTGCCTGACCCCCGCACAGGCGTGCGTCCTGGCGGTCGCGTCATGCCCAGGAGCGACGGACGTCCTCATCGCCGCCTACAGCCGGACGCCGCGCCGACGGGGATGTGAACAGAAAGGGGCGGCCCACCGATTGGCGGGCGGCCCGTCGGCGCGAGGAGTCAGTTCCAGCGGACCAGCGTTGCCAGGTGGTCGTCAGAGCCGTCCAGGGGCGGTTCCAGGTCTGCGACCTTGACGGGCTGAGCGCCGATGGAGGAGAGGTCACCCCGGTAGAGCGTGAGCTTCTCGCCCTCGCCACTGGAGAGGAAGGCAAAGCTCTTGCCGTCCGGCGACGGGACCGGCGTGCGGTTGTCGCGGTCGTTGGCGGGGACCAGGTCCTCGTTCTTCACGACTCTGGAGTAGTCGGACGCGAGGGTGATCTGCTGCATGCCGCAGACCAGGGTGGTGGCATCCCGCCAGAAAGTCGGCGCGCAAGTCTCCCGACCGTCCAGGCCCTTGGTGGTGAGATCGGTCAGCTTGTAGCCGCCGCTGGACCCGCCGTCCGATGTCACGCGGTACAGCGCAAGCATCGGGCCGTAGGCCGGGGTGTCCGACAGGTCGGCGGCGACATCGCCGCTGGGGGTAACTGCCTGCGGCCAGGCGTTCGCCGCAAGAGCCGTGGAGGTGGTGGCGGCGTCCTGAGTGACGACGGCGGCGGCCTGAGAGACATTCAGGTGCTTCTCGGTCGAGTAACCGGCTCGCGCGTCGCGCGAGCCGAAACCCTCGTCGTCACTCTCGTGGTCGCTCTCGTCGTACCAAAGGAGCCCGGTGGTGGGGTGGAAGGCAACTCCCTTGTTCGTCGCCCGTTCGGTGAAGGCGTCCGGGTCTGGCGGGGAGACTTCTTTCCCGGTGGTGAGGTCGTAGGCCCCAGCCCGGGCAGTCTCGCCCGCATCCGTGATGCCGGCGATCAGGCTCATGTCCTTGTTGAAGGCGAAGGTGGCCAGGCTGCGAAAACTGCCTTCTTCACACACCGTCTCCGGCTCGACATCGCTCGGCAGCACGACGCTCCGCTCCCCGACCACAGCGCCGTTCTTCGCGGAGTACGAGCGCAGCGTGAGCCCGTACACGGGATCGCTGTTCCCGTTGGGTATCTCGTGGCAGTAGGCCACCGTCAGGCTGCCCGACTGGGCCAGCGACGCCGACTTGACGTCTGCGGTCTTCTTGCCGTCCCCGCTTCCCTCGGCCCTCGCTCCGCTTCCTCCGTCTGCCGCGCCACCACCGCACGCGGTAAGCACCAGCGCAGCCCCTGCCGCGACTCCGGCATGGAATAGGCGCCTCATCCTGGTTCCCCGTTCGTTTCGTTCAGCAAAAGATGATCATTTAATCAGGTCCGAACAGCGCACGAAGGGCACACGGGGCAGAGCGCCCCTCTCACCGGCGGTCGGAGGCCCAGCTTCGAGGAGAGATCAGTACACAGCGGGTTGCCGGTGCGTCAATCGTGGATGTACTTGCCGGCCGTCCAGCCCGTCCGCCCCTCCCTCTGGCCGTTCAGTACGTACACCCGCATCCAGCCGGCCGTCCTGGCCTTGCACCGCACCTCTACACCGTCGTACTTGAGGATGAGGCCGAGGGAACCGTACTTCGTACCCGGGCCCGTCCGAACCTGGTAGCCCTTGACGTACGTCTTCTCGCGGGCCGAAGTGCCGACGACGGCCGCGGGAGCGCCCGAGCGCGTGGTCGGCCGGCTCGCTCCGGCCTTCACTGCAGCGCCTAGCCGCAACCGTCGAGACCTGGTGGCCAGAGATCCTCGCGTTCCTGCACACTGGGATCACCAACGCCGCCTCCGAAGGCACCAACCGGGTCATCGAGACCATCGCCCGCGACGCCTACGGCTTCCGCAACCCCGGCAACCAGCGCTTACGCACCCGCTGCGCGACCACCCGTCGAGCCCGTGGACACCTCGGTGCCCGCTAATTTCGTTGAGCCCGCACCCTGTGATCGTGTTGGCTAGCGGCACCGAACCGTCAGTACCGCAGGTGTCCGCTTGGCTGTAGCAGGGAGTTGAACGTGCAGGACATTGTTGTCGACCCCGTTGCCCACAATCGGGCAGCCTGGGACAAGTGTGTCCAAGAGGGCAACGAGTGGTCGAGGCCGGTGAGTGCTGAGGATGTCGAGCGCGCCCGCATGGGCGACTGGTCGATTGTTCTCATCGGGCGTGAGCCAGTCGACCGCTCCTGGCTGCCGACGGACCTGACCGGCAAGGACGTGTTGTGCCTGGCCTCCGGCGGTGGCCAGCAGGGTCCGATCCTCGCCGCCGCAGGGGCGCGGGTCACCGTATTCGACAACTCACCCCGCCAGCTCGGCCAGGACCGGATGGTGGCGGCGCGCGACGGACTCGAGCTGCGCACCGTCCTAGGCGACATGCGCGACCTCAGCGCCTTCGGCGACGCAACATTCGACGTCGTATTCCATCCGGTCTCCAACCTATTCGTACCAGACTTGGCACCGGTGTGGCGTGAGTGCTTCCGCGTCCTGCGACCGGGCGGAACTCTGCTCGTGGGCTTCCTCAACCCTGATGCGTACTTGTTCGACCACGAGGCGCTCGACGAGCGCGGCGAGCTGATCGTCGTGCACAAACTGCCCTACAGCGATGTCACGCAGTACTCCGCCGAGGAACGCGCCACGAAGTTCGGCGCGGATGCCCCTCTTGAATACAGCCACACCCTCACCGACCAGATCGGCGGGCAACTCGCCGCGGGGTTCGTCCTCACCGGCTTCGCGGAAGCGCCGCACCAATCCAACGCATCCGCTCAATACATGTCGAACTATTTTGCGACGCTGGCGGTCAAGCCGGGCTGACCCGGCCGTGGGGCCGGCCGAGACGGCCGTGTCTCCGAATGGCCAAGTGGAGCGCTGTGCCAGCCCGACCCCCACTGACTTCGCTGAGCCCTCATCGAGGAGTCCACGTGGAATCGCGGGACTGTCATCACCTGCTCCTCGCTCATCGTCCCAACCTCTTCGGGCTGGGCACGAAGTCCCGCCCTCGATAGGCGGCTTGTGCCATGGCGCGTTCCCTGTGGCTGCTGTCCTGGGCAGGAGGGCCGGCTCCCAAAATCAACGGATTGGTGTCGGAGGGCTGATGCTCCTTTACGGAAGGAGTTCCACGACCGGCTGCGCGTGCAGGTCCGCGAGCGGCTGGGCTGGAATGCGGGGAGATCGACTCGCAGTCGGTCAAGGCGGACGCCGTTGTCGGTGCCGACAGCCGCGGCTTCACCTGCCGCGGTTATGCACGCCATGGAATAGTGCGATAAAATGATGTTGACGCTGTCCGTGGCCGACGCTGCGGTTGACATCACCTGGTGAACAGGAGATGCACATGTCGAAAGACAGCGATGCGGCCAAGGCCGTGTTGGGCCAGTTCCCGGCGGCCCTGACCGAGACGGTTTCCCTCGCCACGCCGCTCACCTTGTCCCGGATCGAAGGCCGGGATCAGGCAGTGCTGGTCCTGCGCGAACTGGCCGAGTCCTTCGGGATCGGCGAGCCGGAGTTCGTCGCCACCGACGACCAGCGGGCCTTCGTTACGTTCGTCGGCCGCGGCCAGGGGCGCGAGGTCGGCCTGTTCGCGGTGCTCACCCGCGGCTCGGAGGGCACGTATTCGGCGGTCGACCTGTACGCCCGGCCCTGGCCGTTCGTGAAGCTGGTCCGTGACCACCTGGCCGCCTCGGACAAGCGGTTCCACAACGATATCGACCTGTCGGTGCCGTACGTGCCCGCAGGGCCTCCCGGCGGCTTCCGCACCGATACGCCCGGCCTGCCCGGACTCTCGGCTGACGTGGCGTTCCACTCCCCGGTGCTGACGGACACCGCCGGCGGAGGCGGGCTGGTGGGCGTCATCCTCATGGCCGTCGAGGAGATATCCGGCGCCCCCAGGTTCCGCGTCGCCACCAGATTCGGCAACGCGTCCGTGGTGCTGTATGACGCCACAGTGCACGGTCACACCTGGCAGCTCGGGCTCGTGATCGGCCTGGACGGCAACGACGAGATCGCCGACATGCGGGTCTACAGTCGGCCGTGGCCGGTCGCCGCGCTCTTCCGCGGCGAGGTCTACAAGCTGCTGCGCGACCGACTCGGCCCGCAGTACTGGCAGGGAGAGAACCCGCTGGTCGCATTGGGAGAAGAGTGATGCCGGCCTGCGCACCGCGTGGAGCGCGACGCGCGGGTCAGCCTGACGGTCTACGACCGGGCCGAGCCGCTGCGATACCTGGAGGTATGCGGTACCGCGACGGTGGCCGAGGACCTGGGTCGGAAGCCGGCGGTCGCACTGGCCGAGCAGTACGAGGGGCCCGGCGCAGGCGAGGAGTACCTGGCACTGCCGCCGGAGGTGGTGCGGGTGGTCGTCAGGATCACCCCGCTGCGGCTGGTCGGCACCTTCGCCGACTGACTGATCTTTTCAAGCGAGTTGAGCCCACGATCTTGTGCCTGACGATCGTGGTCGGCAGGCTGTGCGGATGGGTGCTGATCTTGTTCCGGGCGACCTGTGGGAGCGAGTGGCGCCGCTGCTGCCGCGCCCCTTCCCGAGCGCCGTCGTCGCTACCCCGGACGTCTGCGTGTTCCGGACCGGGCGGCGCTCGCTGGCGTGATGTACGTACTGCGGACCGGCGTGGCCTGGCGCGACGTACCGGCGAGAGCGTGGGCTGCTCTGCAGTCACGGCCTGGCGCCGGCTGCGGGACTGGACCGAGGCCGGCGTCTCGCCCCGCCTGCACTCCGCCCTGCTGGCCGAGCTGGCAGGCGGACCTTCTGGGTATGGATGACTGCGCTGTCGACGGCTCACATGTTTCGGCCCCTCAAGGCCTGCTCGAACTGGCCTGCAGCATTATCTGCCTCCGCCGCCTCAGAACTTCATTCCGAAACGACATACTTAGCGTTCAGGTACGCGCTCGTCCACTGGCACCCCCTACTCCGACGCGTGGTTCGACTGCGAGCAGGCTTTGGGCATGCCGGAGACCATTCGTTTGCGGGCCTTGACCTACCGAAGGGCGATGCGGTCACGACGACAGTTCGGTCCCGGCCTGCTCACGCACCATGTACTGGGCGTACCAGTCCGGCCAGTTCGGGTCCTCCGCACCGATGCGTGCCTCGTGTTCCCCGTGCGTGGCCGCGGCGCGGCGCAGCGCGCTCGCCAGGTCCGCTGGGGAGGCGAACGTCGTGGTCGCGGGATCGAGGCGTCCCGGGAGTCGGGTGGTGACCTCCTGGAGGAACCAGCCGTTGCCGTCCGGGTCGCTGAAGGACAGGAACGAGCCGTAGCTCGTGCGCTGCGGATCCGGCCCCGGCAGCCGGGCGTCTGTCCCGGCGTGGTGGAAGACGCCGCCGGCGTCGTGGAACACCTCGCTCGGCCCAGCGCCGAGCCGTTTCAGCTCATCGTATGCGGCGTTGATGTCGTCCACGACCAGGTGCAGTCCCTGAGCCGAGCCCGGCGTTTGGGACGTGACCGAGGTGCCGAAGATGACCGACGCCGGCGAGCCCGGCGGCGTCACCTGCACCACCCGGAAGTTCCCGTCCGGGGCGATGTCCGCGTCCAGCCTCCAGCCCAATTGCGTGTAGAAGCCCTTGGCCCGGTCGACGTCGGACACCGGCACCACCACGACCTCGAGTTTCATGTCCATGACTGACACTTCCTGTGCTCGTACAAGATGCCGACATGACGAGACTCGCACGGCCGGACGCGGGCCGCGCCCGGGAATCCGGCAGACGGCGGCCCGGGCCACGCTGGGGCCAACTGTCGGAGGGAGCCGACGGCCAGGACGATGGGTTGGGCGGCGATCCGGGTGACGCGCTCGGCGGGCTGGCCCGGCCGAACACCCCGGTGCTCCGCGCCGACAGGCGTGATCGTGGGCTCACGACGCTCGGGCGGCGGTCCAGAAGCAACCGCATACCCATCAGCAGGGAGCCGTGGCGCGCATGGGCATCGGCCGCGGCAGGCAGGCGGCATATGGTCTCTGACTGACGGCACCGGTGCCGAGTCGGGTGAGCAGCCAGAAGGTGATTGCGGTGCCGGTGCCGTAGACGACGTGCGCGCCGAAATCCCAGGCCACGATCTTGGCGTCGTACTGCCAGATCGGCTTGTAGAGCCCTGCGATCGGCAAGGTGACGTAGTCACCGGCGAACACTGCGGCACCGAAAGGCACGCCGTACACGGGGGAGGGGCTGGGCAGTGATCCGGCCACGATGCCGTAGACCGCGCCCGCCGCTGATCCGTAGGCCCAGTGAGCGACGGTGCTCGTGAGCCAGGCGGAACCATCAGGAAGCCGACGCTGCGTGAAGCCCTCGATCACCCGCTTCGCCACCTGCCCTGGATCTGGGGCCTTCTCCCAGCTTTCGACCGGCGCGAATTCCCAGGCGAGCGGGCTGTCCGTCCCGCCTGCGCGACGGTACTTCAGGTAATGAACGGCATCCAGGCACACCGTTCCCACCGCCCCGGCCAGCAGGCCGGCCGTCACCGCCGCGAGGGGAGCCAGCGGATTCCTTCGGGAGCGCACGACGCAATCTCCTCATCGGTCAGGGCCGGGAAGGTTGATGTCTTTCAGCACCCGGGCTGCGGTTGGGCGGCATTGAGCCCACATCGAGTATCCGGCGGCCAGAACATGCGCGCACGAGGAGAACGTCCCCGGGCGCAGGCGGTGAACGGGCTGCGGCGGGCGGTCCTGAGCGGTACTGCGGAAGCAGCGACCGCAGGGGGGCGCTCGTCTGCCGAACCGCCTATCACCGCGAAACGCGTTGGGCAAGCGGGCCAACTGGCCCCTCGCGGTCAGCGTGCACGCGGCCACCAGGCCATGACCGCAGGAAGCGCCCGGGTGGGATCCTCGCACTCGCGAGCCTCTCTCGCGTGGCCCCGGCGGACCGACCCGGGTGCTGCTCCTTCGCCCCGGCGGACAGCTCCGGCTTCCACGGGCTCAGCGGCGACGCCTGCCACGTACCAGGGGCGGCCTCATCCAGGTCAGCGCATGCACACAGGACTCGACGCGCCTGATAGCCCCAGACCTGTTGCCCCGGTATCAGGCCCTGCATACACCCGTCCGAGGGACCAATGAACAGTTACCGAGCCGCGCAGGTAACCGCCCCAGGCGGCACCTTCGAGATCGCCGAGCGAAGAGGTGCCGCAGCCCGGCCCGGGACACGTCAGGATCGCCGTGGAGGCGTGCGGTATCTGCCACAGCGACGCCAATTTCGTCGAGGGTCGGCTACCTGGTGTCAATCCATCTGGCCGCAGACGGCCACGCGCGGCCCCTGGCTCTGGCCGTCACAGCCGGCCAGGCCGGCGACGCGCCCGCCTTCGAGACGGTCATGGCCCGCATCCGGGTGCCGAGAACCGGCCCCGGCCGACCTCACACCCGCCCCGTCACGGTCCTGGCCGACCGCGCCTACTCATCCCGCGCGATCCACGGCCACCTGCGCCGCCGACAGATCCGCGCGGTCATCCCTCAGCCTTCGGACCAGACCGGCCACCGTCTGCGGCGCGCCCGCCAAGGCGGGCGCCCGCCCGGCTTCGACGCGGACGCCTACAAGCAGCGCAACACCGTCGAGCGGCGCATCAACCGCCTCAAACAGTGGCGCGGCCCGGCCACGCGAACCGACAAACTCGCCATCGCCTACCAGGCCGCACTCCACCTCGCCGCCATCCTCATCTGGACACGACGCTGACCGCAGAGACAGAACCTAGGCGCTCCAGCAGGGCCCGGGCCCTCGCCTCGGCGCGCGCTGTCGCAGGCGGCGGCGAGCTCGGTGCGGGCCAGCTCAGCCTGCTAGGCCGTTTCTTTCAGATCGTTGGTCTGGTGTGTCGTTGACTGACGCCCAGTGGGCACGCATCGAGCTGTTGTTGCGGGACCGGAACCGAAGCCGGGCGGCGGTGGCGGGGTCATCGGCGGATGAACGACGCGATCGCGTTCGAGTACCGCACCGGCACGCCATGGATGGACCTGCCCGAGCACTTCGCGTCGTGGAAAGGCGCTCACAACCGGCTGCGGAAGTGGGCCGCCGACAGCACTTGGGAGATGGTCTTCACCGCCCTGCTCGCCCAGGCCGACGCCGAAGGTGACCTCGAATGGGTCGTCGCGGTCGACTCCACCATCGTCCGGGCCCACCAGCACGCCGCCGGGGCCCGTCAAAAGGGGCTCCGGTCGGCGAGCCGCCCGACCATGCCCTCGGACGGTCCCGCGGCGGGCTGACCACCACCAAGATCCACCTCGCCGTAGGCGGCCACTGTCGCCCGCTGGCCTTCGTCATCACGCCCGGCCAGTCAGGTGACGCGCCCGCGTTCACCCAGGTCATGACCCGCTTACGGGTGCCCAGGCGGATCGGCCGTCCAAGGATCACGCCGGACATCCTGGCCGACAAGGCGTATTCGTCCCGCGCAATCCGATCGCATCTCCGCCGGCGCGGGATCCGGGCAGTGATCCCGCAGCCCGCCGACCAGGCCGCCAACCGCAAACGACTCGGCAGTCGTGGCGGCACCGCGTGAAGGAGGCGCACGACCTGCGGGACTGGCTGAGGCAGGCTGCTGCCGGGAGCGGGCCGGACGCTTCGGTGGCCGGCCGCTGGGCGAGGGAGACCGCCACAAGGATCCCGTCCCGGGAGTGAGCGTGCCGGTCGCCGTGACGCTTCAGTGAATCAGGGGTGACGTCGGTCGGGAAGACCGTGCTCCGCCGCCCTGACGATCTGGGCGCGTAGCTGGGCGCAGTCGTCCATCTCGCGCGCGTACAGATCGGGGTTCAGGTCGGCGAGCGGGGCGAGGCTCCTCTCGGAGGCCGCCACCTCGAGCAGCGCCTGGTCGAAGGCGCCGGTCCAGGGGAGGGTGTCCGCGAGATTGTAGTGGCAGGTCGCGATGGCGAGCGCGTACTGGTCGGGTCCGGCGTGCGGCTCCACCTCGCGGGTCAGCTCCAGCGCCTTGTACAGATGGGGCAGGGCCTCGCGCTGATGGCCCATCCGGGAGAGCACACCGGCGTACTGGGCGAGCGTGGCGGCCAGGGCGGACCGGTCGGTGGGCAGGCCGCACACGTCGAGGACTACCTGCCGGATGGCGACCGCTTGGCCGAGCAGGCCCTCCGCGTCGCTCGTCTGCCCGGCCTGCAGGCTTTTCCGGGCCAGGCCTTCGAGCTGAGCCGCCACGCTGTCGCCGTGCTGCTCGGGGTCACGGCGGACCAGGAGGCGGCGGACGAGCATCGCCCGGCGGATCGTGGAGCGCGCCGCCCGGCGCCGACCAAGGGCGAAGTAGAGATCGACGGCGAGGGACAGCACGGCGGTGTACTCGCCCAGGTGGTCGCCCGGGAGATTCCTGATGTCGCGGTCGTAGTTGCGGACGGCCTGGTCAACGAGTCGCTTCGCCCTGCGCAGGTCACCCCGTTGGTCGGGGTTCCCTCGGGCGAGGTCGATCAGATTTTCGGCGAGCATGATCTGGGCCTGGGCCTCCACCCTGGGGCGGGAGATCTTGCTGCGGACGAGTTCGCAGCCGACCTCCAGGCACTCCTCGGCGGCCTCCCGCGCCTCGTCGAGGCGGCGCAGTTCCGTCAGGACGGACGCGTGCTGGAGGAGGGAGTTCCAGAACAGCTCGTTCGGCTCGCCGGCGTCCGCGACGAGGCTTCGTCGGATGGCGAGCCCGCGGCGGATCGGCTCCAGCGCCTCTTCGGGTCTGCCCATGGAGACGAGCGTCCCACCGATGTTGTTGAGGACGACGGCCAGGCCCTCCGCGGCCACCGGGGTGGCCAGGCTCTCCGGCTGGTCGACGACGGCGAGCGCGTCGCGCAGGACGGCGAGCGCCTCCTCGAACCGGTCCAGCACGCGCAGCCGGTTGGCACGGCCGACGAGGCTGCCCACGGCGTCGTGGCCGAGGGCGTCGGGCCGCTCATCGGCCATCTGCCGCAGGGTGTGGGCGGTGGGCTCGGACAGCGTCTCGGCGGCGGCACGGAACTCGCCCTTGCGCTTGAGGGTGTGCGCTAGCTCGGCCTCGGCGTCCGCGAGACGTTCGAGTACAACGGGATCGCCCGTGTCGGCGAGGGAGTTGAGGAGGGCGACGCGCTGTTCCTGGAGGGGGCGCGCGGCATCGTCGTCACCGCTGCCGACGATGACACGGGCACGCTCGCCGAGGATCTCCGCCCGAGCGGGGGCCTGGTCGGCCGGGGTAAGTGTGCCGACCAGCTCGGCGGCCCTGTCCAGCGCGGCCTGGGCCTTGTCGAACTCCACGGTCCAGCGGTGCGAGCGGGCCATGGTGAGCAGCGCGGTGAACCGTGCGGCGGGTGTGGTTTCAGCCTCGCCGGAGTCGTACAGCCGCAGCGCCTCGTCGCATCGGCGTAGGGCCGTCCAGTGGTCCCCGGCGGCCTGCCGCCACCCCGCCTCGTGCACGAGCGCGGTAGCCCGCGGGGTCGGCGGAAGCCCCCGCGCGGCCGTGGCGGCGGTACGCGTGGCCCACGCGGCGAGCACCCGGCTACGCCCCGCGCCCAACCGGTCGAGCAGCTCCAGCAGCAGCTCGGGGTCGGTGTCGGGTGCGTCGGTGAGCCGGTGCAGGGCGTCGAGGAGGGGCTCGGGGGACTCGGTGAGGGTGGTGGCCTCCATGACCGTGCCGGCGAGGGCCGAGTCACGGCCGAGGGCTTCGTCCAGGGCGCGGGCGACGGGGTGCCAGTGGCGGGGGAGTCCGGCCACGCGGGAGAGAGTGACGAGGGCGGCGAGGAGGGTGGGGGCGGCGGAAGGGGCCGGCGGGGTCTCGGCCGACGTCGGCTGCCCGGTGCGGGCGGCCACTGACGCGGTGCGGTGCTCAGGGCTCGGCGGGGCGGGTCGCGATTCGGGGCTGCCGGCGGGCGTCGGCTCCTCGACCCGGGACCGCCACAGCGCCGTCCTCGCCCCCGCCAACGTCAGCAACGGCAGCGTCACCAGGGCCGTGTCCGCCCGCGTCCGGTCCCCCACGTGGTATTCCCCCAGGCGGTCCGGCTGGAGGGCGCCCCAACAGCTATCGCCCGGGGCGGGGTACATCTCGGCGAGCCAGGCCGCGCCCTGGTCCACGGTCGGGGCGTCCGCCGTGCGGAAGCCGGGGGAGGAGCGCAACAGCGGGGCGGCCAGAGCGGGTTCCGCGCCCGCGGTGAGGATTGCGGTGCCCACCGCGTCGGCCAGGGGCACGGGGCCCGCCTCCGCCAGTCGGGGGCGGCCGGCGGCGCTGTCCTCCCAGTACGCGCGCTCGTGCAGGAGGAGTTGCTCCTCGACCCGTAGGCCGGTGTCGTCCGGGCGGGTCGCGGGATGTGTGGCGAGGAGGTCGGTGAGCGCGGTCATGTGCAGAGTGAGAGCGGAGCCGTACTCGGGGGCGCTCACATCGCGCGGGGCGACGAGGGCGACGCGTCCCGTCCAGTCACCGGTGACGTCCCTGAGCTCCCGGGGCAGTGCCTCGGGGAGGCGCCGGGCGAGGTCGGTGAGGGCGTCGTGGTAGTGCGCGTCGCGGTCCGGTAACTCCGTCAGCGGAGGCAGTTCGCGGTGCAGGGTGTCGTAGGTCAGGTTTCTCGTCTCGCGCGTCCGGGTCCTGAGCTGGTCCCACCAGCCGCCCGTGCTGTCGCCCCTCCCTCGCGCGGTGAGCAGCAGCCGTACCGGAGGACGGCCGTCGGGCCGTCGGTCCAGCACAGTGAGCAGGGCGGTCAGTTGGGCGATCCGCAGCTCGGCGTAGTCGGCGACCAGGATCAGTGGGCGGTCCACCTCGGCGAGCACACCGAGGTCCTCGGCCGGGCCGCGCTCGTCCAGCCAGCCGCAGGCCCAGCCGTGCCGGTCGCGCCGCCGGGTGCACAGTTCGCGGGCGAGCCGGGACTTGCCGGCACCGCCGGGCCCGGTGAGGACGGCGAGCTGTACGCCTTCGCCTTGGCACCAGTCGTCGAGCTCCCCCAGCAGGTGCTCGCGGCCGTGGAAGCGGACCACCTCGGCGCGCTGGTCCAGCAGCGTCGCTGGGGAGCGGACCGGCCATCCCGCGGCGGGCGTGACGAGGCCCTGAAGGTCGACCGGCTCCCACACGGGCGGGGCGCCGGTGTGCCGGGTGACCAGGTCCGTGAACCCCGGGTCGGCCAGCAGCGCGTACACCGGTACGGCCTCCCAGCGCGGCAGCCCCCAGCCGCTGACATCGGTCACGACGACGCCGGTCAGCAGCGCGCCGCTGAAGAGGGCCGCGCCGGACTGGCCGCTCCATGGGGAGGGTGTGCGGCGGGCGGGGTCGGCGGGCGGCGCGCTGGCGAGTTCCGCGGTGTAGCGGTGGGACAGGGCGCCGGTGCCGGGGGCGAGGGTGGCGCGTGGCTGCTGAAGATCGAGACCGCCGTCGGCCCGGCGCCCGGCCTCGGGGTAGCCGGCGACGTCGCAGGGCTGGTGCCGGGCAGTGACGAGCCGCCCCCAGCGGACCGGGGCGACCTGCTCGCGGACGTCTGCCTCGGCGAGGAGCAGGGCCGCGTCGACGTGAGTGGCGCCGCGCCAGACGACCGTGCAGGGTACCGCGCGACCGCCGGGCACCTGTACGTCGCAGGCGTCCCGCCCTTCCAGGACATGACGGGCGGTCAGTATAAGCCTGGCGCCCAGGAGATAGCCGGTTCCGTTGCCGCCGTACCGCTGCTCCGCACCCGGCAGCAGGACCGCGACGATACGGCTCAGCTCCATCTGTGCCCCCGTTCACCGTGGTACGCCTGCGGGCGAGTCAGCGGACGAGCCCGCCCCCACCGGTCAGACCGCCCGTCGGAGCGTCGCTGTTGCCGATGCGGATGCCCGCGCCGTCCTGGTCCACCGCGCGCAACGTGAATGCCAGCCTGTGGGCGGCGGTTCCGGACTTCACAGCCCCCGCCTCCCCGGACACGACCCACGCCTTGATGGACCCCTTCCCGCTCTGCTCGCGACGCAGCTCCACCGTGAACTCCAGGGAGATGTCTCCGAGTTCGAAGTGCAGTCCGGAATTCACGGCGCGATCGCGAGCGGCGGTCAGTTCGGCTCGAAGGTGGTCGATGGCTTCGCCGACGGTGATGTCCTTCATGGAGCCACCGTAGCGACGCACCGAGGCGGCTGTCCCCGCGACGGCGGAAGGTCAGCGTGATGGATCGACCAGCGTCGGCACCAGATGCCGCTGCGCATGACGGACGTACTCCCATACGCGCTCCCACCCGTCTTCCTCCCCCTCCAGCCGGGTCCGCAGCCCCCAGGCCTCGGGCAGTTCGTGCTCCTTGATCCACAGCATGTAGCCACACACCGCCTCGCGCCGTTCGCCGATCGCCTCCAGACGGCGGGCGAGCGCGCCGTCGCGGCGGGCGCGGGCGAGCGCGGCGAACATGTCGACCACGGCGTAGTAGCTGAGCACGGCCTCGGTCGTGCGGTTCACGCAGGCCAGCACCACTCCGGCCTCGTACCGCGCCTGTTCCTCCAGTCGCCGGATCCGGCCGAACCGGCTCGGCTTCCCGTGATGGAAGTGGCGCCGGATGTTGCCGAAGTCGGGTACGAAGGGGCCGTCCGTGCCGGCCCCCAGGATGAGGGCGTTCATCGTGTGGACGTACGCCGCGCAGTCCGCCTGCGTCGCCAGGCGCACCTCCCGGGGCAGTCCCGCGGTGAACGGCATCAGAGGCGGCTCGATCCCGTTGCTGAGCCTGCCCTGGAGTATCGGGGTGAGTTCGCGGGCGATGAGGAAGAGGGCACACGCGTTGAAGACCAGGTAGGGGTCCCCGGATCCGTAGGGGATCTCGCCCTCCGGCATGGCCATCGGGATGAGCGGCCGGGGCGGCAGCAGGGAGGCGGCGCGCGGGGGTCGCCAGCAGCGCATGTACGAGGCGACGGTGGCGTCGACGGCGCCCCAGGTGCTGTCGCGGTCGAGCGGGAAGGAGTCGGGATCGGCAGCGCCGGATGCCGCCCCGGTGACGGCGCAGAGGGTGGGCAGGGCCCAGGAGATGTTGGCCATCAATTCAACGGTCTGCGGCGGCAGTCCGATGAGGAAGCCTTGCCGGCCGTCGGCGAGGGGGCGGGCCAGCACCCGGGACTCCGGGTCGGTGGACGGCTGGACAAAGACCTCGACAGTGGAGGCCACTCCTTGGACCTCGTCCAGGCCGGGTATACGCAGGTCGCGCACTCGGTGATCGCCGTCGTCGGTACGGGAGAAGGCGTGGGCGAGCAGGAGCAGGTCGAGCAGCCTGCGGGGCCTGCCGGATGCGTCGGCCAGCTTCTGCAGGTTGTCGAGCAGGGTGCCGGTGGGGTCGGCGCCGCTGACGAAGTCCGGGTCGGTGAAGACACGGGCGAGTCGGGTGGCCTCGGCGGCGAGCTCGGCGCTCTGGTGATCGCGGAACATGAGGCTGGGCGGGTAAGGGAGGGGCGCTGGGTCCGGCGCCCCCTGTGCGAGCAGGCCGTTGAGAGCGGAGCGTAGGGCTCCGCTGTCCCGTACGGGCACGTCGCGGCGCGGCTTGCGGATCACGATGTGCCCGTGCTCGACGCGGGGATCCGACCGCACGACGACATCGGTCGGCCCTGCGAGGCGTACGGCGATGCCGTACCGGAAGAAGTGACTGAGCGCGGCGACGGCGTCCGCGAGGGCGGCGGCGGTGGCGGTGCCGGTGAGGACGTCATCGCCGGGGGCGTTGACGCCCGGCGGGCGTAAGTCCGCGTACGCGACACCGGCCCGGCTCAACACATCTCTCGCGGCGTCCGTCTCCTCGCGATCCGACGCGGCGAAGAGATGGAAGACCACCTGTGCCCCGGTGTCGGCCCCGATGGCCGTCGGTGTCGTCGCTTCCCCCATAGCTCGACAGCATGGCGGCAGGCGGAGGGATGAATCAACCTATCGAAGGAATATGGGGAGCGATCGGAGGAACACCTGCCACAAGAAGTTGGACGCTCTTGTAGGGCACCAGGCCCTTCACCGGACCGGCCGAGCACGACCACCAGGAACAGCACCTGCACAAACACCCCCCACCACCCATCACTACCGCGCCCCCGCTCCTGGCTCCGTTGATCACGGAAAGTCTCTACAAGGCGACCTGGGCACGCCCAGCGGCCTGTCCACCCGGCTGGAGCAGATCCCCGCCGCCGCACTCTCCGGCGGGTTGGCTGCGCTCGCATGCCCACCGGGGCGCGGTCGCGCCAGGGCGAAGCTGACCGCCACTGCTGGCCCCGGACAACGGCCTCAGCGACTGGAACATACCGTGGAGCGAGTGGGTCGCCGGCGGCGCGACCCAGTGACGTCCCGCCGACCACGCCCACCGCGCCACTCCTCCACGCCGCCGGACCGGAATTCCTTCCCCCGGACGGTCGGCCGGCTTCCTCTGAGAGCACCGACGATCGCCTCCGTGGTCTCGCGCACGGTGTCCGGGTCGATGGCCGGCGGGCACAACACCCACGGCGCGATGAGTCGGCGGGCGGCGAACACGGACTCGAGGGCGGCCCTGCGCCGCCGGTAGGGCCAACTGATCGTGTCGGTCCCAGACAGCCGCAGCAGATCGACGGCGACGAAGTGGGCCGGCCACTCGTCCGCGGCCCGCGCCGCCCGGGCGCCGCGTCGTTGCAACCGGTTCTGGAGCTGCTCGAAGGCGAGCCGGCCCGCCGCCTCCCGTGCGACCAACTCGCCGTCCGGCGCGGTAACGTCCGGCATCTGCGCGGCCCGGCGCCAACCTCCGGAATCGCGCCCTCTGTCTCGAGTGACTTGTTGTCGCTTGAGCTGTTCCGATCCGGGACCTCACCGCGCGCGACGGGCACTCGGACTGCCTCGGGTGCCGGCTGGCCGGGCGGCGCGGCGACCGAGCCGGGGACCGTGGCGTCCTGGCGCACGACCAGGCCCCGGTGACCGCTTGCGGCGTCCTGACGGGCGACGAACGGAGCTGTGACGGGTGCCCGCGGCCGCGTCGCCGACCGTCACGGCTCCGCGCCGCCGGTCCCCCTGCTGGCCGACGGCGTCGAGCGCCGGCCCGATCAGGGCGAAAGCCCGGTCGGTCAGGGCCTCGGGGTCCGCGGCGCCGTCGCTCCACCGCTGCAGCACCGTGTCGAACGCGGTCAAAGCGATACCGGCGGCCGGCTGCGGCTACAGATCGGTCCGCGGATCCAGCGACAGGCAGCCGGCCAGCTCTTCGGCCAGCTCATCACGCCACTGGGCTTGGCGCTCCAGGAAGCGGGCGAGGAGGGCGGGCGTGCCCAGGATCAACGGCACGACGCCCAGCGTCCGCTGGGAATGGCCCGCGCACGCGTGGACGGAGACCCGGACGGCGTGGCGCAGTGCCACTGACGGCGGCTCGTCGGCGGGACGGCCGGCCAGTTCCGCCCGCATGCCGGTGCCCATTCCGGCCAGGAACTGGATCACCACGACCTCTTCGGACGCGAAGTACCGGAACAAGGTCCGCTTGGACACGCCTACGACGGCCGCGATCTCGTCGACCGTGACCGCGTGGAACCCCGTCCGGGCCAGCAGCCGCAGTGCGGCTCGCGACAGCTCGAGTGTCATATCAGGCAGCGTGTGACGTATGAGCAAGCAGCGTGGCTGGACCGCCGAGCAGATCCCCGACCTGGGCAAGCGCGTGTTCGTCGTCACTGGAGCAACAGCGGCCTCGGCCTGGCGACCACCCGGGCGCTGTCCCGCAAGGGCGCGCGCGTGATCCTCGCCGTACGGGACGAGGGGAAGGGGCGCAACGCGGTCGCGCAGCTCACCGCCGAGACCCCCGGCGCCGAAGTCGAAGTGCGCCAGGTCGACCGGGCGGACCTTGACTCGGTCCGCCTCTTCTCCGACAGGCTGCACGCCGACCACGCGCCCCTGGACGTGCTGGTCAACAACGGGGGCCTGATGGCGCCACCCCACCGGACGTTGAGCGCACAGGGACACGAGGTGCAGTTCGCGGCCGACCACCTCGGCCATTTCGCGCTCACCGGCCTGCTGCTCGACCTCCTCGAAGCCGGGGACGACCCCCGTGTCGTCACGGTGAGCTCGGCCGATCACCGCCGGGCCACTCTCTTCTTCGACGACCTCACCGGTGAGCGCAAATACTCGCCCATGGGCTACTACAACCGGTCGAAGCTGGCCAACGCCGTGTTCGGCTGGCAGCTCCACCAGCGGCTGACCGCGGCCGGCAGTCCGGTCCGCAGCCTGCTCGCCCACCCCGGACACACCTCGACCAACCTCCAGACGAGCTCGCCGGCGGGCATGATGAAACTCCTCTTCGGAGGTCTCCTGCTGCCGCTCGCCCAGACGCCGGACCAGGGCGCACTGCCCACGCTCTACGCGGCGACCGCCTCGGGTGTGGAGGGCGGGCAGTTCATCGGTCCCGACGGCATGGCCGAGCTGCGTGGTGCGCCGGAGACGGTGCAGCTCGCGCCCCGGGCCGCGGACGCGGAGAGCGGGCGCCGGTTGTGGGACCTGTCGGAGGAGCTGACCTCCGTGCGCTTCGGGTTCCCGGCCGCCGCCTGAGTGATCCCGGAGGGGTGAAGGTGACCGCGAAGACCATTGAGAGCAGTCCCTGGATCCGCTGGTACAACCCGGCCACGAACGCGCGCGCGAGGCTGCCGTGCCTTCCGCACGCCGGCGGATCCGTCCCCTGAACCTGGGGAAGTGCTTGGTGAGGATGGCAGAGAGCCCATTTGTGATCCAGAATGATCGGATGGTCACGCTTGAGACTCCCCGTTTGATCCTGCGTCGCTGGCGTGAGGAAGACGTTGCGCCCATGGCTGCCGTCAATGCCGACCCCGAGGTCATGCGGTGGATCCGTGACGGCAGCGTCCGTGACGAACAGCAGACTCGCGACGGGGTCCAGGCATGGGAGAGCGAGTGGGAGTCGCAGGGTTTCGGCCTGTTCGCCGTGGAGATCCGGTCCACTGGCGAGCTGGCCGGGTTCACCGGCCTTTCGGTGCCCGACTTCCTGCCGGAGGTACTGCCGGCGGTTGAGGTCGGCTGGCGGCTGGGACGTTCCCACTGGGGGCAGGGCTTGGCCACCGAGGCCGCTGCGGCCGCTGTACGGTTCGGGTTCGAGGAGCGAGGGCTGGAGCGGATCGTCAGCATCACTCAAGTGGGCAACGACGCCTCCGAACGGATCATGACCAAACTGGGGATGCATCCGGTCCGTGAGACCGTCAATCCCATCGGCGGTCGGCGAGTCCGGGTGTTCGAGTTGTCATCGGACCAGTACGTCACAACCACTCGTTGATGGCGGCAACGAGGACGGTAGCCTCGTAGCGGGCCGCGAATCTCTCGTACCTGGTGGCCACGGCCCGATGTCTCTTGAGGCGATCGGTGCCGCACTCGACCGCGTGCCGGGCCTTGTAGTCCTCTGGGCCGAAATTCGGTGGCCGACCACCGCTGGACCCGCGCTTCTTGCGGTCGCGGACCTGGTCGGCCTTGTCCGGAATGGTGCAGCGGATACCGCGACGCCGCAGCTAGGCACGGTTCTGGCGGGACGCGTACGCCTTGTCGGTCCGCACCCGTCGCGGGCGCCCGCGGGGCCTGCCGCACCCCAGTCGGGGCACGAGGATGCGGCCCAGTCGCTGGAGCGGCGCGTTCCAGCGGGACCGGTTGAAACTGTCACAGATCCCGCCGAACCGGTTCGCGGCGCTGGCCCGGTATCGTGCCCGCGCCCCACACCGAGCGACCGATGAGAATCGGGTACGACCGTACCTCGACCGCCCGCCAGGAGCGGGCGAGCCAGCTCGCAGCCCTCAACCGCGCGGAGTGCTACAAGGTCTTCCAGGAGCAGATCAGCACCCGCATCAAGGCGCGGCCCGAGCCGGAGAAGGCGCTCGCGCTCGCCACTGGTTCAAGGAGGTCGCACCCGAGACGCCGGTCATATTCACCGTCCACGAGCTCAAGCGGCTCGTGCGCAACGCCGCCGAGCTCCGGGTCGGCGGCATTCAGCTCGAACTCCTCACCGGCCCGCTCACCGGCATCTACGGCCCCAACGGCACGGGCACCATGTTCTTCGCCGTGCTCGCCGTCGCCGGGCAGATCGAGCGCAACTACATTCGGGAGAAGACCTTCGAAGGCCAGGTCACCGCAGCGGCCAGGGTCGACCACGGCGGACGGCCGAAGGTCATGGACGACGGCATGCTCACCTTCGTCGTCGCGCTCAAGAACAAAGGCGTCCCCGTCCCCGAGGTCGCGATGAAGCTGGTCATCACCACGGGGAAGAAGGCGGGCGAGAACGTCTCAGTCGCCCCGCTCTATCGGGCGCCGGCCGAAGCCGAGAAGGCTGCGGCGGACCACGGCCTGACGCTGCGGCCCATGCTTGTTCTCATCCGTCGGCCAGAAGACCTGCTCACCCCCGAGGAGATCGACCTCCGTGAGGTCTCCAGGCCCAGCCCCACCCGAGCACGGAGATCCGCGGCTGAGGCCATGATCAATCTCAGCGCCAACGGCCCACAACTGTGCCAGAGCGGCGTGCGGCAGTCCCAGCCGCAGGTGCACCAGTGGGACCAGGAGCCGGCCGACGAAGACCAGGCGTTGCTTGGGTCCGGCACCAACAGCCATCCTGCGGTCCCCGCCCCGCCGTTCCCGCAAGGCGGACTCACGGGCGGCCTGCCATTTGGGGGGCGAGTTCTTCGAGCAGTTCGCCGAAGTGTGCGCGGGAGACTCCGGACAGGGCAGGGTGGGAACTGGCCGCATGGGCCCAGGCTTGCGTCACAACTTGCCAACCCGTGCGGACCTTCGCCTGTAACGACCGAGCCGCCTGCCATGATCGTCATCATGGGGATACACATTGCACCGGCTGGGGTGGCCGACTTCCACGAGGTCCTGACTGATCATTCCCGTTACTGGGGCGAACGCGACCTTCGGTCGCTGCACCTTCTGGCACTGGTGCAGGAGTTCGGTTCCACCTGCTTGATTGCCCGAGCCGAGGACGGGATCCGTGGGTACGTCTTCGGGTTCGTCACCCCAGACGGCACCGCATACGTGCATCTGATCGCCACGCGGGACGACGCCCGTGGCACCGGCCTCGGGCGTCGTCTGTATGCGGCGTTCGCTGAAGCAGCGGAACGTCATGGTGCACGGCAGTTGAAGGCGATCACGTCAATCGAGAACACCGGCTCGATCGCCTTCCATCGCAGCCTCGGCTTCGACACGAGGATCGTCGACGATTACAACGGCCCCGGCCGGGCTATGGCGGTCTTCCACCGAGACCTGCCGCTCAACGTCTCGTGTCCCTGACCAGCCAGCCGTCACTGGTAATCGGTCGCCAGACGACCTGGTCGTAGTCGACGCCGTCGACTGGCCGTACCGGATCGGGGGCGTACACCCCCCCGGGTACTCCGCCGCCTCCGCACCGCCGTCTTCTCGATCTCGGTACGACGGCAGGCCCACGAGGTACAGCGAGCCACTTGATGCAGGGTCAGCTGGTCTGTACGCCGCGCGCCCCGACCCTGCACCCGCTGCGACGATCAGGCGCTGACGGTAGTCGGGTTGAGGCGTCCGCCCGAGGCCGCTTGCGGGCAACCAGGTCACGCGCCGGATCACGACCGCAGGCCGGTCCCGCCTGCGGCCACAACGTACGCGGTCCGCGCATCATCGGCTGGCGGAGTTCCTCATTCCTTCCACGCCCAGCTCCGCATCGTCATCGCTGTCACCGCCGGCCTTCACCACACCGATGGCGAGTGCGGGCCCCAGGCCTGCCGAACGACTCCCATGACCTCACCGCATGCACGCTCGGGCCATCGGTTCGCGGTGGAGGCACTGGAGCGGTTCCTCGGCCGTTCGGCCGACTGAGGGAAGGACGGGAATCACCCGGGACGCCCTCCGGTTGGCACGGGCGGAAGACGTGATGATCACGGCACAGCCCACCACCGGAAGGATCCCACCCGATGACCACCTCACTGAAGGAGAACATCGGCCGGTACGGCGTCTGGAGCGGCGAGCTGCGCTCGGAGGATCCGGCCCGGCGCGGTGAACTGGACGAAGCCGCGGCTGAGCTGGAGGAACTCGGGTACGGCGCTGTCTGGCTGGGCGGCAACAGCACCGTGGACCACGCCGCCCCGCTCATCGGGGCGACCCGGCGCATCACGGTCGGCACCAGCATCCAGAGCGTGTGGCAGCAGGACGCCGCCACGACGGCGGCCGGATTCACCGAGATCGAGACGGCTCATCCCGGCCGGTTCATGCTGGGCCTCGGCGTCAGCCACGGCCCGCTGGTGAAGAACTACCAGCGCCCGTTCGCGGCGATGACCGGCTACCTCGGCGAGCTCGACACAGCGGGCGTACCCGCCGACCGCCGGGTGCTCGCCGCGCTGGGCCCCAGGATGCTGGCCCTGTCCGGCGACCGCGCGGCCGGCGCGATCCCGTACCTGGTCACACCCGAACACACCGCCCGGGCCCGCGAGATCCTGGGCGAAGGGCCGCTGCTCGCGCCGGAATTCAAGGTGGTCCTGGAGACCGACCCGGCACGCGCCCGGGAGACGGCCCGCGCCTACCTGGCCCGCTACCTGGAACTCCCCAACTACACGGACAACTTCCTGCGCCTGGGCTTCACCGAGGCCGACGTCGCCGCCGGCGGCAGCGACCGTCTCATCGACGCGGTCTTCGCCTGGGGCGGTGAGACCCGGATCCGCGAGCGCGTCGCCGCCTTCCACGAGGCGGGCGCGGACCACGTGGCCCTACAGGTGGTCACGGACGGCACGGACGGCACCCTGCCCAGGGAGGAATGGCGCAGGCTCGCCTCCCTGCTCGCGTGACCGGCCCGGCCCAAGGGGGCACGGGGTGCCCGACGTGCGGCCGCGCGCAACGCAGCCGCAGCCGCAGCCGTGGCCGTACGACAGCCCAGGCCGGGTAGCCGGCACCACGCTCCCGGGTGCCGGCTCGGCTCATTCCCCCGGAAGTTCCGCCTTCGAGCCGTACGCGGCGCTGCTGTGCCGGTACGCCGCCCGCTGCCCCCGCCCGGTCCGGCGCGTTCCCGGCGTCCAGCTCCGCACCCGCGGCTCACCGGACCCGCCGCCCACCGCGCCTCGACACTCCGCCCCCGGACTCCGCGCCCCCGGGTCTCGTCCCAGCTCCAGTGGCGCGCGGCCGCGTCCCGCGCGCGCCGCTCCTCGGCCGGTTCGGCGATCTAGCACGGCTGTCCGCCCGCGCCCGCGGCTCAGGCCCGGCCAGGATCCGGGCAGGCGGCGAGCAGCGCCCGGGTGGTCTCCTCACCGGTGCTGCACACCGGGGCGGACGCGGCCGGCAGCTCCTCGTGGGGCAGCCGCCGGCTGGAGAGCGTTGTGCAGGGCGGCGCGAGCGGAGGACCGTGTGTGTCCACGGGCGCGGGCGGATAGCTGACGCAGGCTCGGGCCGCCGGCAGCCGCCCGGACCTTCTCCATGGCCCCGGCCAGTTGCTGTCTGGTTCCCAGGTCGCGTTCGCACCATCGGGTTCTGCCATCGGCGCCGCGCCCGCTCCCCGGGGCGGCGGAGCCCAGGCCGCATACCGCGGCCGCCGCGTACTGCCGTCCACCGCCGCCCGGTGCCCACGCCGCCACGGCACAGCCGGTCGCAGCAAGCCTCTTGAGGTCCGCGGGCTCACGGAGACCCGCGTCCGGAGTGCGTACGTTGCCAGAGGCGGTCGGCCGGCTCGAAGAGTGCTCGTGCCGCCGCGCGCCAGGGCGACCGCGTCCGCGAGCTGCGGAACGTAGCAGGCGACGAGGACGGGGGAGTGTGGCGCGGAGGGGCATCTGTTACCGGCGACTCGTCCACCAGGCGGGGCAGCACGCTGCGCGTGGCACTGCCCCACCCGCCGGTCAGACGGGCGGGACAGCACAGGCCGACCTGTTGCGAGCAGGCCGTCAGTAGTCGATCTGGCCTGCCGCGCGGGCCGTTCCGCTGAACTGCAGGAAGAACCTGGTGCCGTCCAACACATCGGTAGCGGCCACGCCCCAGCTCCCGGCGCTCAACGTCCGCCAGGCATTGCAGCTCCAGCCGGACCCCGATTTGAAGCACGTCCGCACCGAGCGCGTCCCGTCCAGCTTCAGGTTGATGTCGTTGCACCGGGTGGTGGCGGTGGCGTAGGTGCCCCGGGCGGGCCAGTACGCGGGGTCGTTGGAACCGGTCCCCGGGTAGCTGGTGAAGCGCGGTGCGTCGACCGTGCAGGCCCGCGCGGGGCTGACGTCCGATGCTGAGGCCGAGCCTGCTGCCGCGGCTGTCATATGCTGTCCGGCGGCCGAGGTGGTGGCCTCGGCGGTGCCGGCGGCCGAGGTCACGGCGAGCAGGACGCCCGCCACAAGGGCGGCGCGACGGAGCTGGGTGCGGCTCGTTGTGCGCCTGGTTGTGTGCCTCATCAATCTCTCTGCCTTCCAGAGGTTCTCCGGTGCGCTTCTGATGTGTCACCGGGCTCACCCAGTCTCCGGGCACGCAACACGCATCGCCTTAGCGAGACGTGCCAACTCGTTAGCACGGAGCGCCAGGTACGACAGATCATCCGGAGAAGGCCGAGAGAAGAAAGATCATTCACGCGAGGTCCTCCGCGCCCTTGGGCACGGCAGGGCCTGGTGTCGATAGTCGACAGGCGCGACACCGTAGGCAGAGCGGAAGGCACGAGTGAAATCAGCGGGGCGGAGATAGCCCCACCGGGCGGCGATGGCCCTGATGGGCACGTCACGCTGGACCGGATCGCCTAGATCGCGGCGGCAGCGCTCCAGGCGCTGCTCGCGTATCGAGGCGCGGACGTTCGCGCCGTGTGCTTGGAAGAGCCGGTGCAGTGTGCGGACGGAGATGTGGTGGGCCCCCGCTATGCCGTCGATGCTGAGCATGGGGTCGCCGAGATGGTCTTGGATGTACGAGGTGACACGGGCGTACAGGGCTCGTTGCCGACTGTCGGCCGGGATGTCGTCTTCCCGCTCCAGATGATGGGCGAGAACAGCAGCGGCCAGGTCGAGACCGATCGTACCCAGCCGAGGCATGTCTGCGGGCGTGTAGCACGTGTGGTTGTCCGTCACACGGGTCAGGTAGTCGACCAACAACTGACCGATCCCTTTGTCGGCAGGCAGCCGACAGGCGACCAGTTGGTCAACACGGCGTGCACTCACCGGCAGCAGGGCGATGGGGAACCGCATGAGCGTTGCTTCGCCGATGGCGTACGACTCGAACGGTCGGGAACTGCTCAAGAGCACCAGCTCCCCAGGCCCGACGAGACTGCTGCGCCGATTCTGCTCGATGAAATGAGGTCCGGAACGGGGCACAACAATCTGTAGGCACTCCGGGTCGGAGACGCGGATGGACTTCGATGTCCGGGAGGTGGTTATCGATGAGTAAGCCATCGAAGAAACCTGAACCGGCCCCAATGACATTTCATCGAACCAGCCGCGGAACACGTCACTGTCCACAGCACGGAACGTCTTCGGCATGACTTCTCGCCGAGCCGTCTCCGTCCAGGCGGCCAGAGCCTCTTGCCCCGAGAAGTTTCTGCTGTCGAAGACCCGTTCCATGATCCCCTCCGGGTTCGATGAGCAACGTGCACCGGATTACCAGCCGGCGTCCCTTGCCGACAGGGCCGAATCAGGCAACGTCATGGGTAGGCACCACTTCTGGCCACCGGACAGGCCGCCGACAGCCCGCAGTTCAGCTACGCGGGCGAGCTCGGCCTGGGCGTCCGCGAGACGTTCGAGTACGACTGGGTCACCGCCGTCGGCAAGGGGCGGGTACGGCGACGGCGAACTCCGCGGTCACCGTCTTGCCCGCGATGACGGCACCGGCTTCCAGCAGCCGGTCCACCACCGCGGCCCGGCGGCCGGTCAGCAGATCGGCCCATAGCGCGGAGCCTGCGCGGATGGGCAGCCCGTCGACGTGCACGGAATTCTTCACCCAGACGGGGATGCCGTACAGCGGCGGGCACCCGGCCGGCCCCTCGGCACACTCGGCCAGGCCACGGGCCGCCGCCCGCAGCCGGTCGGCCCGGCCGGGCTCGGCCACGAAAGCCTGGACGACATCGTCGACTTCGCCCGTCCGCCCGAGGGTGTGTTCCACGTTCTCCGTCACACAGATGGCCGACGTCCGCAGCCGTTCGGCAGAGGGCACCAGGGCGCGCTGCGCACACGGTCTTCCATGGCTTCTTTTATACGCCGCCGCGCCGAAGGGCCGGCTCGGGACGCCCTCGTTACCTCTGCGGCGGACTTGCCACCGGCTTGCTCTTGGTAACGACACCACCGAACACGGCGATGCCCTTGATCACGACGCGCGGGGTTCCCGACTTTCCGATCTTGCGGGCGCCACGCTTGCCGAACACGCCGAACAGACCGAAGCCCTCGACCTTGACCTCGATGTCGTCCGGGACGACGATCTCGGTGCCTCCCCACAGCGCGACGGCACGGATTACGGTCTCCTGCTCGGCGAAGCGGGCCTCGCTCAGGTCGAGCCGCCCGCCGCCCCAGATGGACCAGGCCGTGAACTTCGGCGGGACGACCCATTCACCCTCGCGCTCGAAGCCCCCGAACATGCCCAGGGCGAAGCGTGAGGTAGGCACGCGGTCCACCACGAGCGCGTCGCGGGGCCCGGGTTCGGGAAGGCCACGGCCGGCGGCCTCCAACTCGCCCATCGTTCGCGCGGCGTACACTGCGGCGAGCCGTTCGTCCAGTTCGCTGATCTCCAGGCGCCCGTTCACAACGGCGGCCCGTACCCGCTCGGCCGCGTGGTTGCGGTCGTCGTCGCAGACACGCACCTCCCTACCGGACGAGGACACTGGAGTTATGCGCTTCATCTCATCCGAATGTTTGGTGTGTTCAGTCATGCACTGAACCTTTTCACACCTTGCTCCCTCACGGCCTTCGTCCACTGGTGAAGTGGCGCCACCCCTATGGTCGTTCAGGCGGGGAGCGCCTGTCGCGGGGGCTGGCGGGGGCTGGTGGCTCGCCCGCATCGGCGCCGTCTATCTGCCGCTCGGCCCCCGCCCCGGCGAACGCCGTACCCAGGCCGTCAGCGAGGACCTCGACATCGCCTGCCTCGTCGGCGACCCCGGCGTACTGCCCGCCGCCCACCGCGCCGGCGAGCGGACCCCGCTGCCCCTGCCCACCGACGGCGTGAACGCCCCCGCCACCGCGGTGGCGGCCTCCGCCGCGCACGACCGCGGCGCGCGGCGAGCCCCCGAAGGCGCCTTCTACGCCGTCCTCACCTCCGGGTCCACCGGCCGCCCCAAGGCGGTGGCCGTGGCCGAGGACTCCCTGTCCGTCGCCCTCGACTGGTACCGCGACGAGACCGGACTCGCGCCGGGGGACCGCCAGTCCCTCCTCATCGGTGTCGCCTTCGACCCCCACCTGCTCGAACTGTGGGCCGCGCTGACCTCCGGCGCCGCCCTCGTCCCGGCCCCCGACGACACCCGCTGGACCGCCCGCGACTGCGACGCCCCCGTACCGATCGGCCGCTCCATCGCCGGGGCCACCACCCACGTCCTGGACAACGACGGCCGGCCCGTCCCGGCGGGGGAGCGCGGCGAACTGTGGGTCGGCGGCAGCAGGCTCGCCCACGGCTACACGAGCCTGCCCGGACTGACCGCCGAACGGTTCGTCGAGCACCCGGCCGGGGGCCGCCTCTACCGCACCGGCGACCTGGTATCCGCCCGGCCCGACGGCACCCTCGACTTCTACGGCCGCAACGACGACCAGGTCAAGGTCCGCGGCTTCCGCATCGAACCCGCGGAGGTCGAACACGCCCTGCGCCGGTACGACGACGTCGGTGACGCCGCCGTCACCGTCGACCGCGCGGGCACCCCCGAAGCACGTCTCGTTCGCCCTCGTCGTCGCCGCACCCGGACCCGCGCCCACCGGCGTCGCGCTGCGCGAACGCCTCACCGCCGTCCTGCCCGCCCACCTGGTGCCCGACACGGTCACCCTGGTGGACCGGCTGCCCCTCACCCCGGCCGGCAAGGTGGACCGGCGCGCCCTGGCCGACCTGGCCCGCACGACCGGCAACGGCCACCCCGGCACTTCGGCGACGGCGATGACCCCCGTGGAACAGGCCGTCGCCGACGTCTGGAGCCGCTCCCTGGGCAGCGAGGTCACCCGCGCGGACGCCGAGTTCCTCGCCCTCGGCGGTCACTCGCTGCTGGCCCTCGCCGTCACCGACGACCTGCGTGAGGAACTCGGTGTCGAGCTCACCCTCACCGACTTCTTCGCCGCCCCGACCGTCTCCGCACAGGCAGCCCTGGTCGAACGGGCCCTGATCACCGCCCACCAGGATCCGCACCCCCAGACCCCGGAGCACCAAGATGCCCACTGACGCCGACCCCACGGCGCCGACCCGGCGGCAACTCCAGCAGGAACTCCTGCGCCGGGCCCGGGCCGGCGCCGCCCGGCGCACCACCACCGCCCCCGGCGGCGGCGCGGCGACTGCGGACGCCGGTAGTCCCGAACCGCGCGACACGCCCGGCGCCGCCGCCCGGCACGGATGCCACCCGCTCTCGCGCGCCCAGCGCCGCATGTGGCTGATGGAACGCCTCGGCGGTGCCGGCGACTCCTACCACGTGCCGTTCGCCACGCGCGTGCGCGGACCGTTCGACCCGGCCGCGTTCGCCACCGCCCTCACCGCGCTGGTGGCCCGGCACGAGATCCTGCCCACCCGCTACACCGAACAGGACGGCGAACCCGCTCAGGAGGTGCTCCCGCCGCCGGCGGCCGTCCCGGTGCACGCGGCCGACACCGACCCGGCGCACGCTCCCGAAGCACTGCGCCGCGAGGCGGCCCGCCCCTTCGACCTCGCTGCCGGCGAGGCCGTACGCGCACTGGTCCTGCGCCACGGGCCGCGGGACCACACCGTACTGCTGACCTTCCACCACATCGCCGTCGACGGCGGCTCGCTCGACACGGTGGCGGCCGAACTCGCCGTACTGTACGAAGCGGCCGGCGACCCGGACGGCACCGACCCGCTCGCCGCACCGCCGCAGTACGCCGACCACGCGCACCGCGAGCACGACGCCCTCCCCGGCCTGCGGGCCGAACTCGACCACTGGGCCGACCTGCTGGCCGGCGCCGCCCCACCCGCGCTGCCCCGGCCGGCCACGACCGCACGGGACACGACCGCCCGACCGGCCGCCGTGCACACGGTGCCCGTCGCACCCGGCCTGCCCGACGCCCTGCGCCGAACGCCGCGCCACCCTGTTCGCGGTGACACTCACCGCCGCCTTCGCCACGCTGCACCAGCTCACCGGCGACGACGACCTCGTCATCGGCGTGGCGAGCACCCACCGCACCGGTACGGCCATGCGCGGACTGGTCGGCCTCTGCGTCAACACCCTGCCCGTACGGGTCGACACCTCCGGTGACCCGTCCTTCGCCCAACTGCTGCACCGGGTGCGTGACGCCCTCCTGGAGGCCCAGCGCCACGGGTACCTCCCGTTCGACCTCGTCCTGGAACGCCTCGGCACCCGGGCACGCGGCACCGACGGCGCCGGCCTGGTCCGCGTCACCCCCCACGCGTCCGGCGGCACTCGTCCAGTACGACCCGCGCGCACTGGACGATGCCGTGGCGCGGGCCACCGCCCGGGGACCACGCCCACCTGCTGGCCGCGGGCCGCGGCCGACCCGGACACACCGCTGAGCGAACTCGCCGGCCCCGGCACCCACCCGGCACCCGCCGGGGACGACCCCGGACACCCGGCGGCCCGGGCCCTGCGCGCCCACCCGCAGGTCGCCGACGCCGACGTGCACGAGCGCGACGAGGAACGGCCCGTGGCCTACGCCGTCCTGCGCGACCAGGTTGCCCGTGGCGTCGTAGTGGAACTCGGTCTTCTTGCCGTTCGCGTCGGTGGTGGTGCACACCTGCCCCTGGCAACCACCGCACCCGGGGGTCGCCTCGTTGTAGGCGAGGGCCCGGGTCCCGCCGCCGGTACCGCTGGTGGCGACGGAGGTGGTGTAGCCCCGCCGCGTCATAGGAATAGGTGGTCTTCTCGCCGTCGGCTCCGTTGGTGCTGCTGGGACATTCGGCGCCGGCGCTCGTCTGCCACTGTCCGGGTGCTGGTCAGGGGGCTGGCAGGATCGTGCCGGTGATCTCCAGAGCCCCGCTCAGCGCGGTGATCGCGAAAGCATCCGCCTCGCAGCGTGGCCCGGGATCACCCCGGGCGCCGATCTGTGCGGTGGTGGGTCAGCTCAAGGCCGAGAGCGAGCAGCAGTTGCCGGCTCACCTGGTCGAACTGCTCTTGGAGAGCGGAGGGGTAGTTCGGCGCGCCCACGGAGTGTCAGGGAGGGTACGGCTGCCTAGATGATCGATTCCAAGGGGTCAGTGGTCATAGGCGGTCAGTGAGCGCAGGACGGGTTGTCCGGTGTGGTCGTTGTGCCAGATCGCGGCGGTCAGCGCGAGGATGCGCTGCATGACGCGGGCGACGACCCCGCCGGCCGTGCGCCCTCGGTGCTGTTCGAGATCGAGCTGGCCCTTGAAGGTCTCATTGACCGACTCGATGATCTGCCGCAACGGCTTGAACAGGGGAGCTCCGGGCCGCTCCGGCTCGCCCTTGCGGGCCGGCCGCAGCAGCCGGATGTCCTGCTGGGCCAGCTCGTCTTCGAAGCCCCGGCCGAAGTAGTTCTTGTCGCCGATCAGCGTCTGGGCAGGACGCGCGGCGACGAGGTCGGCTTCGGCGGAGAAGAGATCCAGCAGGGTCTCGCGCTCGTCGGCCTTGGCCCCGGTCAGGGCGAACGCGACCGGCAGGCCCTGGAGGGTGTACACCAGGCGCAGCCGCAGGCCCCAAAAGAAGCGGCTGTGGCTGGCGCAGTACCCGTACTCGGCCCATCCCGCCAGGTCGGAACGCTTGACGGTCTCGCGTGAACGGCCGCATTCCACTGGCGTGGAGTCCACGATCCACACGTCGTCGCTCCACACCGAGGTATCGGTGGCGAGCAGCCGGGTGACCCGCCGAAGCAGTCCGGCACCCTTGCGCAGCCGCTTGTTGCAGCCGGGCTGCTTGGGCAGGTAAGGAAAGAGATACCGCAGGTGGGAGCGGGCATAGCGGAGCCACCTGGCCTCGGAGGTGAAGCCGAGAATGGCCTGCATCATCGCCAATGTGACCAGCTCGGCGTCGGTGAGCTGCGGGACGATCCCTACGGTCGGCCGCCGTGGCGCGAGATGCGGAGACGCCTTCAGCAGGTCGTCGGTCTTCACATAGAGTGCGGTCGCGAGGGTGTCCAACTCTGTCATCACACAATGACGTTGGACGTCCTCGCCGCGTGCGCGCAGTCAATCCGTCCGAATCGATCAGTCGGCGAGGACCCCCGTGTTCTGGCAGGCGGTCAGCAGCCAGCGGCCGTCGTCCTGCTTGGTCATCACGTACAGCGGGGCGCCCTCGCTCTCGTCGTCCGGGGTCAGGTAGCGCTGACGAACCTTGACCGCTGCGACGTCGGGGCGGATGAAGAGCACATGGACTACCTCGTAGCTGACCTTGCCGTCCCAGTTGGCCGCGGGGAGCACCTTGCGGGTGAACTCCGAGATCGCGTCCAGGCCGATGAGAACCTTGCCGTGGGCCGTCGTCCAGACCGCGTCGGGGTGGAAGAGGGCGAGGAATTCGTCGGGGTCCTTGTGCTGCTGGGAGTGCTCGACGGTGGCAACGACCTGCTTGACGGCTTCGATGTCTGCGGCGTACGCCGTGGATTCCGTGTTCATGTGGACCATGGTGCAACCTCAAGCACGGTTGAGATCAAGAGGGTGATCGGTCAAGGGATCGGCTGCGCGAATTCGGCGAGGGCGTCCATTGAGGACGTCCACTGACCCCTTGGAATCGATCATCTAGGCCTGGGCCCAGCGGATCTGCTCGGCCGCCCACGCGGCCCACTCGCGGCGCATCGCGTTGAAGCGGAGGCCGTACTCCAGGGCGATCTTGCCGTTCACCGACAGCGGGTCGTCGTCCCAGTCGATGGAGTCGGCCAGGCGGCGCAGGGCCTCGTACTCCTGCTTCGACAGCTCCATGAGCTCGGTGAGGTAGCTCCGCGCCTGGTCGGGCGTGATCACGTTCAGGAAGAAGACCCGCAGCAGGATGTCGCTCCGGGGGTTGCGTTGGGGCTTGGTCTCCGTCAGCCAGTGGCGCAGCTCCGCCAGGCCCTCGTCGGTGAGGGTGTACTCCTTGCGGCCGCGCGGGCCTTGGGCCGAGACGCTGATCAGCCCGTTGTCGGCGAGCTTGGACAGCTCTGTGTACATCTGGCTCTGTGTGGCGGGCCAGACGTTGGCCAAAGAGGTCTCGAAGCGCTTCAGCAGGTCGTAGCCGCTGGCCGGGCGCTCTGACAGGAGTCCGAGGAGGGCGTGTCGCAGGCTCATGCCTTCACTTTACCTTCCACTCTTGACATGTCGAGGGTGTGACTTCTAGTTTCAACATGTCATAACAGGAATGTCAGCAGCCCGGGGGCCTTCGATGTCGTACGTACGCACCTTCCTTCCATGGATCGTCTTCGCGGTGGTCCCGTCCGCCCAGTGGCAGTGGGGGGCACTCGCCGGGCTGCTGGTGGCGGTGGCGGTGATCGCCCAACAGCGGCGGACGGGAGTCGGCTTCGACGCACTGATCATGGAAACCGGCTCGGCCGTCTTCTTCGCGGTCCTGGCGGCCGTCGCCTTCGCAGACCCCCACTCGGCCGCACACGCCTACTCGACGGCACTCTCCTCGGCCACCCTGGCCCTCATCGCCGGGGTCTCGCTGCTCGCGGGCAAGCCGTTCACGCTGGGCATCGCCAAGCGCACCACCCCACCCGAAGTCTGGAACCTCAAGCCCTTCGTCCGGGTCAACGTGGTCATCACCACCGTATGGACCGCCGCATTCGCCGCCACGGCCGGCGCCCTCGCGGCCCTCGCCCACGCCGGCCAGGGCCACTCCGCGACGGCGACCCTCGTCCAGGCCGCCGGGTTCGTGGTCCCCATGGTGTTCACCCTGCGCTACGTCGCCACCGCCCAGGCCAGGGCCAGGGTCTAGCACCGATCCCTTCCGTGCTGGAGCAACTGGGCTCCCCGACTGCTTCCCTCACCTTGAGCCATGTCGCTGACCTGGGCGTTTCCTGATCCTGGTCGCCGATCCCCGCGATGGGCGGGGACTGCGGTATCCGGCGGTCGCGTTGCTGTGCGCGGCCGTCTCGGCGGTGCTGGCCGGGGCCCGCTCGCTCATCGCGACCAGCGAGTGGATCACGGATGCCCCGCAGTATGCGCTGGGTGTCCTTGGCTTCGCGGCCGATCCACTCACCGGTCTGCGACCGGTGCCGCACGCCGCAGCGGTGCGCCGCCTGCTGCAGCGTGAGACGGTGATGCGCCGGACGCGGCGATCGGCGCTTTTCTGCAGGCCAGAACCCCACCCCCGGCCGATTCGGAGACGAAGGCGGGGCCGGCGGCGGGTGATCGCGGTCGACGGCAACGTGTTACGCGGTTCGCGGACCAAGACCCCCACGGCGGTCCAGACTGCTGGCTGCGATGGACCACTACGGCGTGGTCCTGGCCCACGGGTCCATGCCGCACGGCTGCCCGGCGCGCTGGCACATCGGCGGACAGGCCGGGGCGGGTGCCGCGGGCAGGACACCGTCAGGCCGGCCGTCACATCGCCATCATCACGAGCCGTCGCAGCGCCTCGCGGGCGCGACACAGGCGCGCCCGTTGGGCTTCACGTCGATCTTCACGGCGGCTGCGTCGTCTTCGCTCGGGTGCCCGGCCGCGGCTGCCCCCGTCCGTCTGCGCGCCCGCCCGAGCATCCCTAGGTCGTGTCTTCAAAAGATCTTGAGTGGTGGATCATGGTGGGGTGATACGTCGCCATGAACTGTCGGACGCCGAGTGGGAGTTCGTCCGGCCGCTGCTGCCGGAGCCCTTGCGGGGGCGGAAGCGGTTGGACGACCGCACCGTGCTCAACGGGATCGTGTGGAAGTTCCGGACCGGCACCGCCTGGAGGGATGTGCCCGAGCGGTACGGTCCGTGGGCCACGCTGCACACCCGCTTCCGCCGCTGGGCGCTGGACGGCACCTTCGAGCGGATGCTCCGTGCCGCCCAGGCACAGGCAGATGCGGCCGGGGACATCGACTGGCTGGTGTCGGTCGACTCCACCGTTGTCCGCGCCCACCAGCACGCCGCCGGAGCCCGAAAAAGGGGCTCCGCAGCCCCGGCCTCGGACGCTCCAGGGGCGGCCTGACCAGCAAGATTCACCTGGCCTGTGACGCATTGGGCCGCCCGCTCGCCTTCACGATCACGGGCGGGAACACCAACGACTGCACCCAGTTCACCGCCGTGATGGAGGCGATACGGGTGCCCCGCCTAGGCTCGGGACGGCCACGCGTGCGGCCCTCCCATGTCCTGGGCGACAAGGGCTACAGCTCGGGCCATCCGGACTTGGCTGCGACGCCGGGGTATCAGCCACACCATCCCCGAGCGGGCCGACCAGGTCCGCAACCGGCACCGCCGCGGCAGCCGGGGCGGGCGCCCGCCGGTCTTCGACAAGCAGCTCTACAAGCGGCGCAACGTGGTGGAACGGTGCTTCAACCGCCTGAAACAGTGGCGCGGTATCGCGACCCGCTACGACAAGACCGCCGAGTCCTACCAAGCAGCCGTCACCCTCGCATCGCTGTTGATGTGGGCGTGACATTTGAAGACAACTCCTAGGGGAGGCGCGGACGGGCCCGGCGGCAGGAGGAGTCCGGCCCCGGGCAGCGGAGCCGTCAGAGGGCCGCTTCCGGGCGGGACGGGGGTCGCGCGTGTTTCAGCCACCGTCACTGCCCGGGTGTGGCGGGCCCGGCGCCCAGAGCGCGACGGCCGGGCGGGCGCGTGGGGTTCAGTGCGTGAACCCGTTGCTCCGTTCCACTTTCGCCACGTGCAGCGTGTAGCTCTGATACCACTCGGCTCGCCCGCGCTTTTGCGCCGCGCGGTGCTCGGCGTTGGTCCGCCACTCCGTGAGGGCGTCGGCGTCGCGGAAGTAGCCGACGGTGATGCCCAGCCCGCCAGGAGTCTGCGCGTGGTCCATCCCCAGGTACCCGGGGACGTCCTTCACCAGGTCTTCCAGGCGTGCGTCGGTCTCGCTGTAGCCGCTCTGGTCCTGGGTTCGCACCGTAGTGAAGACAGCTACGTAGTAGGGGGGTTCATAGGACCCGACGGGCGCGACAGGCGCTTCGGAGCGATTGCTCATGGCGCCACCGTAAGGCGGGATGCGTCGCCGCGCATACACCTCTATTTCGATCTTCATCCGCGGGTCGGCGAGACCGCACATGAGCATCGTGGCGGCCGGCCGGACATCGCCGAAGTAGCTGCGCAGGACCGGCCAGCAGGGTTCGAAGTCTTCGCGGTCGGGCAGCAGGTAGCGCACGCGCACCACGTCGGCGATGGTGCACTTCGCCTCGGCCAGTGCGGCTTCGATGTTGCGCAGGCACTGCTCGGCCTGCTCCGCCGCATCGTCGGAGATCGTCATGGTTGCGTAGTCGAACCCGGTCGTGCCGGACACATGCACCCAGTCGCCGTCGACCACAGCACGGGCATAGCCGATCTGCTCTTCAAAGGTCGAGCCGCTGAGGACCGCGCGTCGCTCTGTCATGCGCCGAACGCTAAATGGTCAGCACTAATACGTCTAATAGGGCCGCATGCATTGTCTGATATCTCTAGGCGTATGGAGCGCCCCGAACTTCCCCTACCGCAGCTGCACGCCTTCGTCGTGCTCGCAGAGGAACTTCACTTCGGCCACGCGGCCGCCCGCCTGGGCATCGCCCAGCCGCCGCTGAGCCAGCAGATCCGCCGCCTGGAGGACAAGGTCGGCCACGCGCTGTTCAGCCGCGCCTCAGGGCGTGTCACCCTATCCCCAGCCGGCAGCGAACTGCTGCCCGCCGCCCGGAGGGCACTCACCGACCTCGCGGACGGCCTGGCCGCAGCCCGGGCCGTCGGCAGTGGCCGGGCCGGCTGCCTACGGATCGGCTTCGCCGCCTCCCTCGCCCTGACCATCCTGCCCGGCCTGCTGCGCACCTTCCGTCACCAGTTCCCTGGCGTGCACCTGGACATCCACGAGATGACTACCGCTCCGCAGATCGCCGCCCTGCATGACAAGACCATCGACATCGGTCTACTGCGCGAACCTCCCACCGACGAGACGGAACTCGGCTTCAGGACGGTACTCAGCGAGCCTTTCGTGGCCGTGCTGCCGTCCACCCATCCTCTGGCTACCCAACGGACCGTGCAACTTGCGCAGTTGGCGGACTCGCCCTTCGTGCTGCTGCCCCGCACGGTCGGCCCGCCACTGCACGACCAGATCATCGGCCTGTGCACGGCAGCAGGGTTCACACCGCAGGTAGTCCAGCACGCGGTGGAATGGCAAACCGTGTGCGCCCTCGTGGAAACCGGTCTGGGCGTCTCCCTGGCCCCGGCGAGCATCCGGCGCATCCGCCTCAAAGGCGTCGCCTTCCGGAGGATCGAACCCGGCACCGACCGCACACGAGTGGCCGTCGCCTGGCGCGAGAACGACCATAATCCCCTCGTCACGGGCCTGCTGGCGACCATCAGCCAAGATCCGCCGGACAGGCCCTAGGCCCGCGCGGCCGCGAAGAAGGCCGGCGGAAGGCCGAAGGTGATGCGTGACAACGGAGACGTCCGCAAGGGCGCCCGCGTCGCGGGCGACGTCTGCGCCGTCTTCGAGCGGGCCGCGGGGTGGGATGCGGCTGACGTACAGTCGGGCTGGACCGTGCCCCGGTCCGAGCCGCGGCGGCGGGTCGGGCACCGGAAAGGTGCCCGACCCGGACCCTTGCGGTTGCGCCGAGCCGATCTGCTGGACCTGAACGACTGCACACTCGGCAGTGCGCAGGGCGTGGCACCGGGCGGGTGGATCCGGGGGCCCGTTGGTTCGGGTCACCCGGATCCGCCTCGGCTGTGGGGGCAGGTGGTGGGGCTGTTACTTCGGGGCGACGAGCGAGTGTTCGGTGCCGAAGGTGGCGCCGGTGTGTGTGTACATGGTGGTCTCGCCGTCGGACCAGCGGACGACGAGGTCGTCCGGCCAGCCGTTGGAGTCGTAGCTGCCCGCTGTCATCACCGAGTCGTGGGACCAGATGCTGCCGGCCGGGGCCATGTGGACCTCCTTGCCGACGCCGCCGGGGCCGGTCTCCTGGAACTGGGAGACCCTTCCGTCGGACCAGCGCACCAGGGCGTCCCAGTTGTTGCCGCCGGTGAAGTCGCCCGCGGTCACCAGGGTGGCGTCCTTCCAGGCGCTCTTCGGCTTCGCCAACTGGTGTTCGGTGCCGAAGCCCTTGTCGCCGACGGCGGTGTAGTCGGTGACCTCGCCGTCGCTCCAGCGCACCAGCAGGTCGCTGACGTACTTCGCGGTTCCGAAGCTGCCGCCGGTGATCTGGTCGGCGTGGCTCCAGATGGATCCGGCGCCGGCCAGTTCGATCCCGCCGTCCATGCCCTTGGTGCCGACATCGGGGAGGAGCCTGACCTCGCCGGAATTGAACACCACCAGCAGGTCCGAGCCGTTGCCGCCAGAGAAGTCCCCACCGGTGAAGGACTTGACGTCCTGCCAGACGCCGTGGGGTGCGGCCAGCCGACGCTCGCCGGTGAAGCCGCCGTTGCCGTCACCGGTGTACAGGGTTACCTCACCGTCGGTCCAGACCACGATCAGGTCGCCCTTGCCGTCGCCGGTGTACTCGCCCGAGGCCAGCAGCTTGGCATGGGACCAGGTCTCACCGCCGCCCATGGAGTACGGCAGCGGCGGCTGGTCGTAAGTGGTGCCGTGGGACACGTGCTGGTCGTTCTTCGCCTCGTCGTACAGGCGGAAGAACCAGTCGCCGTGCATGGGGCTGTACGTGAGCCAGTCCACGTTCGCGTCGTTGCCGCCGCCGTTGTACCCGCCGACGTTGCCGATGATCTCACCGGTGCCCTTCGCCCAGTCCACCTGGGAGAACCAGGGACCGCCGGAGACACCGCTCCACATGCCGCGGCACTTGGCCTGGATCTGGTAGAAGCCGGGGAGCGCCTCCGTCTGCGTGAGGCACCGCACGGGATGGTCCTCGGGGTCGTGGCTGGAGGGATAGCCCAGCATCGTGACCTTGTTCAGGTAACCCGGCGTGCGCACCAGCTTGTTCGCGCCCACCACGTCCTGCGCCTGCTTGCCGCTCTTTGAGGGCTCGAGCCGGCCGAAGGAGAAGTCCAGGTCTGAGATGGGCTTCTTGGTGTTGTGCACGTACCGGTTGTCGGTGAACCACTTGGAGATCCGGTAGAACCCGAACGTCTGCTTGTCCAGCGTGTACTCGGCGGCGTACTGGGGGACGAAGACGGCCTTGCCACCGTCGCAGTGCCCGGCGGTCAGGATCAGATTGTGCCCGGGGCTCTCCACCACGCTGGCGGTGCACTTGTGCGCGTGCATCCGGTCGGTGGTCGGATCCGTGTCGTAGGTGAAGATCGTCCCGACGGACGGCAGGCCGAGGATGTGCTCCGCCGTCGGCATGTCGGCCGCCACCGAGGGACCGGCCGGGGCCGCCCGCCGCACACGGGCCTTGGCGCTCGGGTCCGCCTGCTGCGCGGACAGTGCCGGGTCGGTGGCCGAGGCCATGCGTTCAGGCGTCCAGAAGCGGATGGCGTCCGCGTCCGACCAGTCGTCGTCGCCGGTCTTCGGCTCCGTGGAACCGCCCGCGCTCGCCGACGGCGAGGCCGAGGGCTCCCCCGTTCCGTTCGGGGTCGAGGGGCCGGCAGATGCAGAGGGCGCGGGTTCAACGGACGGTCCGGCTGACGTTCCAGCGGACGGCACCGTGGTCGCAGACAGGTGGGGCGCCGGTGTGACGTCCTGAACCTGGGCCTGGGCCTGGGCGAGGCTTCCCCCTCCCGTCAGGAGCAGAGCAGTTCCGGCCGCGAGGACCACGAGGCGCGATATTCGTCTGTGTGAGGTATGCAAGGAATGCTTTCTGAGTCGTGGGACAACTGAACCGCCTCCGGGCCGGAAACGGCCAGAAGGAGCGAAGGAAGAGCGAGGAAAGACGGGGACGGTCTGCGGCTGCCGGTTTGCCTCTACGCGGAGGGCTCGGCCTTGCGTGAGCGTTGGCGCCGCACCGTGAACACTCCGCCGGAGGCGAGGGCCAGTCCCGCGGCTGCGACGCCACCGGCGACCGCCCAGGAAGGGCCGCCGTCCTTGACGGGCTGGCCGGCGATCGTGACGTGCTGTGTCGTGGTCTGCTGCCCATGGTGGCTGACCACGGTCACGGTGTAGCGGCCGTCGGGTACATCGCCTCGCAGTCGTGCGTGGCCCGCGTAGACCGTGCCGGCGTCGTCGCATTTGCAGCCGGGGTTGTCCGGGCTGTTGGTCTTGATGGTCAACGGTCCCTTGAAGATGGGCGACGTGACGGTCAGGGAGTTCTCCCCCGGTGCGGCCCGCAGGTCGGTGAGGACCACCCGGACGTCACCGCCCGGCCGGAGGGAGGCCGGCGTGCCGCTGCCGGGGAACGCGTCCCGGGGACCGATGACGAACCGGTCGATCTGCGCCGAGTTCTCGGCCGCGACCTTGAGTGTGGCCGTCGCGACGATACGGCCGTGGCTGGTCGCGGTGACCGGATAGGCGCCCGGGCGCAGACCCGAACGGATGCGATGCTCTGAGCCCTCCGCGTCCACCTGCACCGACTGCGTCGACCCCTTCTTCAGGGGAGTCAGGGTGATCGGCTCCTGCAGGGCCGGGGAGGTGACCTTGACCTTGTCCCATCCCGGTGGCATTCCCTCGAGGCTGAACCAGAGGTCGTCACCGGCTTCCAGGGCGAGGTTCTGAGCCACGTGGTACTCCAGGCGGACGCCCGGAGACGGGCTCACACCCTCGGCGGCCGACACCCCCGCCGCCCCTCCCAGCAAGGGCACCACGGCAAGACCGGCGACGCCCACGGCCCGAACTGCACTGCGGAACAACGGTTCCCCCTTGGTCGGCGATGGCTGGGCCGGTTCGACCGCGTCCATCTGTCGACCAGGAAGAGGACAGAAGCGGGCAGTTGGTTGCCGACGACCAGCGCCTGTGGTGCTTTCCTGCCCGGCGCTGGCGGGGTGTTCGTCGTCCGGTGCGCATTCGGGAGGGAAGAACGGGGCCTGTGCTGCTGGGCCGTCGGGGGCGGCGGCCGCGGGGACGGACGTCTCGCCTCGCGCCGCACCGCCGACGATGTCGGGGTCCTCGGCCGGCTGCACGAGTGTCTCGTACAGGCTGTCGAAGGGCGGCTCCATGCAGACCGCCCAGGGACTCGGCGAAGTGCCTGGGGCAGGGGCTCAGGGCGATGGCGTGGTCCAGAACCGGGAACATGCCCCACTCGTCGATCCGTTGCTGCAGCGCGGCCAGGGCCGGAGTGTCCGGCAGGAGCAGCCCGTGCAGCACGTACAGCGCGTAGAAGCAGCACAGGCCGACCAGCACCGTCCGTGCCCCCACCAGCTCCTCATCACTGGCCCGCTTCACCGGTCCCACCATGTACGTTGCTGCTGGAGCAACCCCAGTCCACCGGGGGCCCCTCGCCGCGCTCCGCCGCTCCGAGCGCCTGCTCCCAGTCCTCGACCGTCAGCCCGAACACGCCGCATGCGGCGAACGCCTCGGCCGGCGCGTCCACCCCGACCTCCTGTGCTCCCAAGCCGAACGCGGTCCCGCGCGCGGGCCGCGGGCGCGGCTCCTGAGGGTGCGGCTCCATACTGTCGGCGATGTCGTTTTCCAACCTGTACGCCGTCGCCTGCCTCCGCCGCGCTGCGCAGCCGCGCCATCCGGTTGCCCCGGCCCGCGCCCTCTTCGTCGCCGGTTCGCCGCTGGCTACTTACGCCCGCCCACCCTCCAAGCCCGCGCCCCGCCCGAATCCGGCCGTTCTCCCGCGGCCGTCGGCCGCCGCCCGTGTCGGCCACGCCTGGGCCGTGGGCGGCCGCCGTGTCGGCGTCGTGCCCGTGCCGGGCCGGCTGCCGCCCGCCGGAGGCTGCCATGCTCCGCCCGGCTGGCCGTCGTCCGGCCGCGCCGCCCGAGCCGGAGGGCCATCATGACCAGGAGCGGGGCGAGCTTCGGAGGCCTGTTCCGCTGCCGTACTGGCAAATCTCCGTCGGATTGAGCAGTGAGTCGCTCAACAGGTCTCTCGGTAGAGCAGTTCAGGGATCAACGATTGCCAATCCGCTGTACGCATGCCACCGCTTGAACGGCGGGAGATGGATTCGACGATGGACTCGGGGGAGTACGTCAGGGCGGTCACGGACCCAGGCTCATTGCTTCCCGTAGTGCTGGTGGTCCCGGTGAAGGTGCTCAACCGCCGTTTCTGAGCCCGGTCCCAGACCGTTACCCAGCCGGCGTCGTCACCGGTTGCCACACGGTCGCTGCTCGGAGGGCCGGGGGCGACGGCGGCCGATGCCGGTTGTACCTCGAGGTACCGGCACCCTGCGTTCCGTATCCAGGTGCACTTCCCGGATGCCATGGCGGTGCAGCGGATACCGGTATACCGGTATACCGGTGTGCTGAGGTCTGCGGCTCTCCACACACGCATGGTGTTGTCGTCCGCCGTCCCTTTTCGCTGAGGGGGTTCTCGTCGCACCGTTGAGCCTGTGCCCGGCCACGACGGACCGGGCCGCGGCCGGAGACTGGCTGCACCCGGCGTGGGGCGCGGCGGGCGTGGAAGGCGTGATCGTGAAGGGCCGGGCCCAGGCGTACCGGCCCGGACGTCGTGGCTGGATCAAGGTGCGGGCCAGGACCACGGCGGAGGGCCTGATCGTCGCCGTCACGGGGACCGTCCAGGAGCCGAACACTTTGCTGCTGGGCCGTTACGACACGGCGGCCCGGCTCCGCCTGGTCGCCCGCACCGCGCCCCCATCACCCCGCGCCAGGTCCGTGGTCCGGCCGGTCCCGACCGGCCGGGGCAGCCGTACCGTGCCGCCGTCGAGGGGCATGTAGTGTGCTGCGCGCTCCGTGCCGGGTTGCCCGCCACTGCCGCCGCTCGGCCTCTGTCCGGTCCCCGCCGCGTCGACGGGTCTCGCTGCCCGGCCGTCGCGTCCGTCTGGCCGCCGCCGGGCGGCCGTGCCGGGCCGCGCGCTCCGTCAGACTGTCTCCGGCCCGGCGCCCGCCGCTGCCCGTCCGGCCCGGCCTTGCCTCACAGACTCTGCGGTCCTCGCCGTCCCGGGCGGTCTTCCGGCCTGCGGTCTCGGGCGCTGCCTTCTCGTCCGCATTGTCTCTACCCGTGCCCGGCCTGTGCCCGGCCTGTGCCCGGCCTGTGCCCGGCCTGTGCCCGGCCTGTGCCCGGCCTGTGCCCGGCCCGTGCCCGGCCGTCGGCGGTTCTGTCGTCGGGTTGCAGGGGGAGGCTCCCGCCGGGTCGTCCCGCTGCTTCCCGTGCGGTGCCTGTCTCGCGTCTCCGACTGGCCGTGCCCCGCCGGACCCCGCGGTTCGCTGGCCAGCAGGGGGGAGAGGTGGCCCGTCCGGGCAGCGTGCGAGGGGCCTCGGGCGGGCTCCGGTTCGTATGGTGCCCGTTGGAAGATGCCGGAAGGCGGCGACAGGCCGGGCACGGCTCAGGCCGGCGCGGCCCTGGTGGTCAGGCGACGTGGGTTTCCAGACGGCGGGCGAAGTCTTCGAGGGCGGCGAAGTCGTCGTCGCGCAGTCCGCACCGGGGATCGACATGCCGCAAGAGCGCAGGGGCATGGTGGTGTGCCGCGACGAAAGCCCGGTCTGGCTCGCCGAGGTCGTCGTCGACCCACGCGAAGGGGCGACCGCTCGCGTTTTCCAACTGGTCTGTGGGTGTTCGTGTCCCTCGTTTGGGTGCCCTCTACCGGCGCCCCGTGCCGGTTAACCGACTGTCTCCGTTCTCTTCGGTACGTGTAGGAGATCGGTTGGGGAGGCAGGGGTGGCACGTAGTCGAGTGGTCCTCGGGGACTTGCGGGTGCAGGTGCTGGAGAGGGCTGGCGGTGGCAGGTCGTACACGGTCGTGTGGCCGGACTGCACGGTCGACGCGGAGGCGGACTCGTATCTGCGGCCGTTCGAAGGGTCGGGGTCGCAGAAGACGTACGCCTACTCCTTGGTGGATCATCTGCGGTGGCGGATCCGGGAGGGGCTGAGCACCGAGACGATCACGATGCGTGACCTGCACCGTTATATGGGGGCGGTGGGTGCCCAGGTGCCGATGCCGTACGGACAGCCGTGGCGGGTGCCTCCTCAGCGTCCGTACGGTGCCTCGGCTCTCCAGGTCGCGGCGGCATGCCTCAAGGGCTTCTACCTCAATGCGTGCGCAAGCAAGGGTGTGAACGGTGAGCTGAGGGAGGCCCTGGCGGTCACTCGGCTGCCGACGAGGGTTGACCGGGACCGGGCTCTGCTGGGGCACGTGAAGACGTCGATGACGGCCAACCCATTGGCTCCGAAGCGGCCGCCGCGTCGTCGGCACCCGAAGATGCTGCCTGAGGGGGCGAAGGTGGATTTGCGGGGCGTGATGAACACGGCCCGCGACGAGATGGTCCTGCAGTGGCTGTCGGACACGAGCCTGCGACCGGGCGGGCTGGCTGGGCTTCACCTGATGGACCTGCACCTGCGGGAGAACGCGGCCTGCGGCGAATGCAAGGGCCCTCACCTGCATGTCTGTCATCGCTGGGGCAACCCGAACCGGGCCGCCGCGAAGATCAAGCCGGAGTGGAAGGTGGCCGACGGGGTGATCACTGGCGGGGAGATCTACCGCGCCAGCCCCGCCATGATCAGCAGCTACTTCAAGTACATGACGACGGAGTACGCGAAGTACGCCACGGGGCACGGGATGCTGCTGATCCAGCTGACGGGCCCGAACCGTGGAGAGCCCTGGAGCGCGGATGCCGCCCGGGGGATGCTGCGGCGAGCTGGCCGAAGGGCCGGGTTGCCGGGGAGGATCACGCCCAAGGCGTTTCGCCACCAGATCACCAACGACGTGCTGGACGTCACGAACGGCGACTCGATGGTGGCCAAGGCCGTCGGGAACTGGGCGTCGGCCAGGATGGTCGATGAGGTCTATGGCCATCCCGACCTGCACTCGCCCGAGTTCACGGCTGCGCTTCAGGCGGTCTGGGGTGAGGACGAATGA

Protein sequences of DBSCAN-SWA_3

>CP033073|7900224:7954363|7902858_7903080_-|AYN43267.1|DBSCAN-SWA
MSRYPARSRAPGPLEWPAARPATRWSSAAGRVIGLGSGGGGRIVAADPPERVARAAGQGGGALLGPGRALSRA
>CP033073|7900224:7954363|7919415_7919715_+|AYN43283.1|transposase|DBSCAN-SWA
MNDAIAFEYRTGTPWMDLPEHFASWKGAHNRLRKWAADSTWEMVFTALLAQADAEGDLEWVVAVDSTIVRAHQHAAGARQKGLRSASRPTMPSDGPAAG
>CP033073|7900224:7954363|7924574_7926266_-|AYN43287.1|DBSCAN-SWA
MGEATTPTAIGADTGAQVVFHLFAASDREETDAARDVLSRAGVAYADLRPPGVNAPGDDVLTGTATAAALADAVAALSHFFRYGIAVRLAGPTDVVVRSDPRVEHGHIVIRKPRRDVPVRDSGALRSALNGLLAQGAPDPAPLPYPPSLMFRDHQSAELAAEATRLARVFTDPDFVSGADPTGTLLDNLQKLADASGRPRRLLDLLLLAHAFSRTDDGDHRVRDLRIPGLDEVQGVASTVEVFVQPSTDPESRVLARPLADGRQGFLIGLPPQTVELMANISWALPTLCAVTGAASGAADPDSFPLDRDSTWGAVDATVASYMRCWRPPRAASLLPPRPLIPMAMPEGEIPYGSGDPYLVFNACALFLIARELTPILQGRLSNGIEPPLMPFTAGLPREVRLATQADCAAYVHTMNALILGAGTDGPFVPDFGNIRRHFHHGKPSRFGRIRRLEEQARYEAGVVLACVNRTTEAVLSYYAVVDMFAALARARRDGALARRLEAIGERREAVCGYMLWIKEHELPEAWGLRTRLEGEEDGWERVWEYVRHAQRHLVPTLVDPSR
>CP033073|7900224:7954363|7953166_7954363_+|AYN43304.1|integrase|DBSCAN-SWA
MARSRVVLGDLRVQVLERAGGGRSYTVVWPDCTVDAEADSYLRPFEGSGSQKTYAYSLVDHLRWRIREGLSTETITMRDLHRYMGAVGAQVPMPYGQPWRVPPQRPYGASALQVAAACLKGFYLNACASKGVNGELREALAVTRLPTRVDRDRALLGHVKTSMTANPLAPKRPPRRRHPKMLPEGAKVDLRGVMNTARDEMVLQWLSDTSLRPGGLAGLHLMDLHLRENAACGECKGPHLHVCHRWGNPNRAAAKIKPEWKVADGVITGGEIYRASPAMISSYFKYMTTEYAKYATGHGMLLIQLTGPNRGEPWSADAARGMLRRAGRRAGLPGRITPKAFRHQITNDVLDVTNGDSMVAKAVGNWASARMVDEVYGHPDLHSPEFTAALQAVWGEDE
>CP033073|7900224:7954363|7913559_7914351_+|AYN43278.1|DBSCAN-SWA
MQDIVVDPVAHNRAAWDKCVQEGNEWSRPVSAEDVERARMGDWSIVLIGREPVDRSWLPTDLTGKDVLCLASGGGQQGPILAAAGARVTVFDNSPRQLGQDRMVAARDGLELRTVLGDMRDLSAFGDATFDVVFHPVSNLFVPDLAPVWRECFRVLRPGGTLLVGFLNPDAYLFDHEALDERGELIVVHKLPYSDVTQYSAEERATKFGADAPLEYSHTLTDQIGGQLAAGFVLTGFAEAPHQSNASAQYMSNYFATLAVKPG
>CP033073|7900224:7954363|7900224_7902375_-|AYN43265.1|protease|DBSCAN-SWA
MGWFRNRWDSSDDPSRHVVTVRRTEDGKPAGAGFVLGPDTVLTCAHVVNVALGRDMFDTRPPGVGEVPVEVRDDDMVRGRRLSSRVAHWIPPRARGGGPVTAGADEWLGDLAVLRVDAPAGGLPPPPRQAAMTAGQKAEAWHGGGRASTIARLTVSGLHGRLAYLDGASTGMAVGPGYSGSPLWCREEQAVVGLVVGHFMPVDDAGAPLELGFQGVIRRSWAVPWQAVEAELGSLGVLDGIRPSPVEPDDPAFEVLLGVIEDLLPSPSGRGDCARRLARLCGVEPGSDVVPPTPEEFTAFVLTRPRAMPALTAILRRDDPRGAERVLAAGALSRTPRLLTSAEYKELCGHLRALSPTVLERFPEVVRAALPHLAARPGGETVDALLDHLETLPGDGHANADERRVPALLRVVEYVGALCPDTRRAQLRLWADGVARRLGIERSALGERRFDAQEWARSARVRATRVRVLVQVANAGRDRHRLRIWCDEGAGPRQVSTESVKPYSTSEAARQVLGVLDSLTPPAEDERPPLVEVLVDRGGLNLPVDEWTAGDHPAELVPGVLGVEFPLVVHCPELLRRNGRFVSRWRSRWSRLDSGRALVVSEPTDRDTLYSRLVNQLDTVRVSVDVPPGPPRDRIVQTCLALGIPVVMWDRREDGPSHSVRHMSRVATRELPDGVHDYRANAQANPPEFPGRPVLAWADADRSVPRLHLSEPQEGP
>CP033073|7900224:7954363|7902378_7902774_-|AYN43266.1|DBSCAN-SWA
MSTSPDLALSDGTPVRFLLTSVAGAVPSAVDDDLPEGMGRAVPVGAGSRAVANFAADALRAALRPIGPLLQEVHNVATAVPEPPTELSVTFGVQVGHDLKFGIVGAAGQAHLTVTASWKPGADAGATPGAE
>CP033073|7900224:7954363|7942773_7943325_+|AYN43296.1|DBSCAN-SWA
MSYVRTFLPWIVFAVVPSAQWQWGALAGLLVAVAVIAQQRRTGVGFDALIMETGSAVFFAVLAAVAFADPHSAAHAYSTALSSATLALIAGVSLLAGKPFTLGIAKRTTPPEVWNLKPFVRVNVVITTVWTAAFAATAGALAALAHAGQGHSATATLVQAAGFVVPMVFTLRYVATAQARARV
>CP033073|7900224:7954363|7934242_7934677_-|AYN43291.1|DBSCAN-SWA
MAGVLLAVTSAAGTAEATTSAAGQHMTAAAAGSASASDVSPARACTVDAPRFTSYPGTGSNDPAYWPARGTYATATTRCNDINLKLDGTRSVRTCFKSGSGWSCNAWRTLSAGSWGVAATDVLDGTRFFLQFSGTARAAGQIDY
>CP033073|7900224:7954363|7906571_7907186_-|AYN43271.1|DBSCAN-SWA
MPWNMNGTYLESCNCDAVCPCTTSGLTAPADHERCQVTLAFHVESGNVDGVDVSDRSVAVFIDAPRVMAEGDWQVALYLDASADDGQAESLGKVFSGRAGGPMAALTPLIGDVLGVERVPITYRDDGRRHAAQVGDAIDIEIEDQVAPQFGEDGPVMSLTGMFHPANSTLTIARSTRATGDGVYGRTWDFSGGNGHSAPFSWSA
>CP033073|7900224:7954363|7934899_7935880_-|AYN43292.1|DBSCAN-SWA
MERVFDSRNFSGQEALAAWTETARREVMPKTFRAVDSDVFRGWFDEMSLGPVQVSSMAYSSITTSRTSKSIRVSDPECLQIVVPRSGPHFIEQNRRSSLVGPGELVLLSSSRPFESYAIGEATLMRFPIALLPVSARRVDQLVACRLPADKGIGQLLVDYLTRVTDNHTCYTPADMPRLGTIGLDLAAAVLAHHLEREDDIPADSRQRALYARVTSYIQDHLGDPMLSIDGIAGAHHISVRTLHRLFQAHGANVRASIREQRLERCRRDLGDPVQRDVPIRAIAARWGYLRPADFTRAFRSAYGVAPVDYRHQALPCPRARRTSRE
>CP033073|7900224:7954363|7940657_7941572_-|AYN43294.1|transposase|DBSCAN-SWA
MMTELDTLATALYVKTDDLLKASPHLAPRRPTVGIVPQLTDAELVTLAMMQAILGFTSEARWLRYARSHLRYLFPYLPKQPGCNKRLRKGAGLLRRVTRLLATDTSVWSDDVWIVDSTPVECGRSRETVKRSDLAGWAEYGYCASHSRFFWGLRLRLVYTLQGLPVAFALTGAKADERETLLDLFSAEADLVAARPAQTLIGDKNYFGRGFEDELAQQDIRLLRPARKGEPERPGAPLFKPLRQIIESVNETFKGQLDLEQHRGRTAGGVVARVMQRILALTAAIWHNDHTGQPVLRSLTAYDH
>CP033073|7900224:7954363|7920157_7924156_-|AYN43285.1|DBSCAN-SWA
MELSRIVAVLLPGAEQRYGGNGTGYLLGARLILTARHVLEGRDACDVQVPGGRAVPCTVVWRGATHVDAALLLAEADVREQVAPVRWGRLVTARHQPCDVAGYPEAGRRADGGLDLQQPRATLAPGTGALSHRYTAELASAPPADPARRTPSPWSGQSGAALFSGALLTGVVVTDVSGWGLPRWEAVPVYALLADPGFTDLVTRHTGAPPVWEPVDLQGLVTPAAGWPVRSPATLLDQRAEVVRFHGREHLLGELDDWCQGEGVQLAVLTGPGGAGKSRLARELCTRRRDRHGWACGWLDERGPAEDLGVLAEVDRPLILVADYAELRIAQLTALLTVLDRRPDGRPPVRLLLTARGRGDSTGGWWDQLRTRTRETRNLTYDTLHRELPPLTELPDRDAHYHDALTDLARRLPEALPRELRDVTGDWTGRVALVAPRDVSAPEYGSALTLHMTALTDLLATHPATRPDDTGLRVEEQLLLHERAYWEDSAAGRPRLAEAGPVPLADAVGTAILTAGAEPALAAPLLRSSPGFRTADAPTVDQGAAWLAEMYPAPGDSCWGALQPDRLGEYHVGDRTRADTALVTLPLLTLAGARTALWRSRVEEPTPAGSPESRPAPPSPEHRTASVAARTGQPTSAETPPAPSAAPTLLAALVTLSRVAGLPRHWHPVARALDEALGRDSALAGTVMEATTLTESPEPLLDALHRLTDAPDTDPELLLELLDRLGAGRSRVLAAWATRTAATAARGLPPTPRATALVHEAGWRQAAGDHWTALRRCDEALRLYDSGEAETTPAARFTALLTMARSHRWTVEFDKAQAALDRAAELVGTLTPADQAPARAEILGERARVIVGSGDDDAARPLQEQRVALLNSLADTGDPVVLERLADAEAELAHTLKRKGEFRAAAETLSEPTAHTLRQMADERPDALGHDAVGSLVGRANRLRVLDRFEEALAVLRDALAVVDQPESLATPVAAEGLAVVLNNIGGTLVSMGRPEEALEPIRRGLAIRRSLVADAGEPNELFWNSLLQHASVLTELRRLDEAREAAEECLEVGCELVRSKISRPRVEAQAQIMLAENLIDLARGNPDQRGDLRRAKRLVDQAVRNYDRDIRNLPGDHLGEYTAVLSLAVDLYFALGRRRAARSTIRRAMLVRRLLVRRDPEQHGDSVAAQLEGLARKSLQAGQTSDAEGLLGQAVAIRQVVLDVCGLPTDRSALAATLAQYAGVLSRMGHQREALPHLYKALELTREVEPHAGPDQYALAIATCHYNLADTLPWTGAFDQALLEVAASERSLAPLADLNPDLYAREMDDCAQLRAQIVRAAEHGLPDRRHP
>CP033073|7900224:7954363|7945980_7946889_+|AYN43299.1|DBSCAN-SWA
MERPELPLPQLHAFVVLAEELHFGHAAARLGIAQPPLSQQIRRLEDKVGHALFSRASGRVTLSPAGSELLPAARRALTDLADGLAAARAVGSGRAGCLRIGFAASLALTILPGLLRTFRHQFPGVHLDIHEMTTAPQIAALHDKTIDIGLLREPPTDETELGFRTVLSEPFVAVLPSTHPLATQRTVQLAQLADSPFVLLPRTVGPPLHDQIIGLCTAAGFTPQVVQHAVEWQTVCALVETGLGVSLAPASIRRIRLKGVAFRRIEPGTDRTRVAVAWRENDHNPLVTGLLATISQDPPDRP
>CP033073|7900224:7954363|7916538_7917156_-|AYN43281.1|DBSCAN-SWA
MDMKLEVVVVPVSDVDRAKGFYTQLGWRLDADIAPDGNFRVVQVTPPGSPASVIFGTSVTSQTPGSAQGLHLVVDDINAAYDELKRLGAGPSEVFHDAGGVFHHAGTDARLPGPDPQRTSYGSFLSFSDPDGNGWFLQEVTTRLPGRLDPATTTFASPADLASALRRAAATHGEHEARIGAEDPNWPDWYAQYMVREQAGTELSS
>CP033073|7900224:7954363|7941626_7942031_-|AYN44052.1|DBSCAN-SWA
MNTESTAYAADIEAVKQVVATVEHSQQHKDPDEFLALFHPDAVWTTAHGKVLIGLDAISEFTRKVLPAANWDGKVSYEVVHVLFIRPDVAAVKVRQRYLTPDDESEGAPLYVMTKQDDGRWLLTACQNTGVLAD
>CP033073|7900224:7954363|7908262_7908514_+|AYN43272.1|DBSCAN-SWA
MAQHRNGPTATIEASFQGAATVGFPLVLVRAVRCSFVTSERLPARTPVADQGSRGSEVGCVRAGSHSYTRANSWRGGGDSEAC
>CP033073|7900224:7954363|7909542_7910376_+|AYN43274.1|DBSCAN-SWA
MADRPLTLMAVHAHPDDEATGTGGVLARYAAEGIRTVLVTCTDGGCGDGPGGVKPGDPGHDPAAVALMRRKELEASCDVLKVSDLEMLDYADSGMVGWPSNDAPGSFWQTPVQEGATRLAELMRYYRPDVVVTYDENGFYGHPDHIQAHRITMAALEMTALAPKVYWTTMPRSMMRRFGEIMREFHEDMPEPDPAEAAAMAEIGLPDDEITTWVDTIAFSGQKFDALAAHASQGENIFFLKMGKERFGELMGMETFVRVQDATGAAVPENDLFAGLR
>CP033073|7900224:7954363|7948900_7949137_+|AYN43300.1|DBSCAN-SWA
MRSGVQKRMASASDQSSSPVFGSVEPPALADGEAEGSPVPFGVEGPADAEGAGSTDGPADVPADGTVVADRWGAGVTS
>CP033073|7900224:7954363|7947249_7948716_-|AYN44053.1|DBSCAN-SWA
MHAHKCTASVVESPGHNLILTAGHCDGGKAVFVPQYAAEYTLDKQTFGFYRISKWFTDNRYVHNTKKPISDLDFSFGRLEPSKSGKQAQDVVGANKLVRTPGYLNKVTMLGYPSSHDPEDHPVRCLTQTEALPGFYQIQAKCRGMWSGVSGGPWFSQVDWAKGTGEIIGNVGGYNGGGNDANVDWLTYSPMHGDWFFRLYDEAKNDQHVSHGTTYDQPPLPYSMGGGETWSHAKLLASGEYTGDGKGDLIVVWTDGEVTLYTGDGNGGFTGERRLAAPHGVWQDVKSFTGGDFSGGNGSDLLVVFNSGEVRLLPDVGTKGMDGGIELAGAGSIWSHADQITGGSFGTAKYVSDLLVRWSDGEVTDYTAVGDKGFGTEHQLAKPKSAWKDATLVTAGDFTGGNNWDALVRWSDGRVSQFQETGPGGVGKEVHMAPAGSIWSHDSVMTAGSYDSNGWPDDLVVRWSDGETTMYTHTGATFGTEHSLVAPK
>CP033073|7900224:7954363|7917429_7917990_-|AYN43282.1|DBSCAN-SWA
MTAGLLAGAVGTVCLDAVHYLKYRRAGGTDSPLAWEFAPVESWEKAPDPGQVAKRVIEGFTQRRLPDGSAWLTSTVAHWAYGSAAGAVYGIVAGSLPSPSPVYGVPFGAAVFAGDYVTLPIAGLYKPIWQYDAKIVAWDFGAHVVYGTGTAITFWLLTRLGTGAVSQRPYAACLPRPMPMRATAPC
>CP033073|7900224:7954363|7942154_7942679_-|AYN43295.1|DBSCAN-SWA
MSLRHALLGLLSERPASGYDLLKRFETSLANVWPATQSQMYTELSKLADNGLISVSAQGPRGRKEYTLTDEGLAELRHWLTETKPQRNPRSDILLRVFFLNVITPDQARSYLTELMELSKQEYEALRRLADSIDWDDDPLSVNGKIALEYGLRFNAMRREWAAWAAEQIRWAQA
>CP033073|7900224:7954363|7903505_7904324_-|AYN43268.1|DBSCAN-SWA
MTERRQQMATTSNAGHPLPYDTYREEIERETRRFADAVRGADPAGAVPSCPDWTLAELARHVGSLQRWFCTLLSRRVQEFPRSRDVELGLPDDPRDYPDWVTAGVPDVAAVLRDTAPDAPMWTWGEDRHARFWARRMLFETLVHRVDAERAVGRETAVDPVLAADGVDEFLANLPYAGLFAPAVTKLRGDGETIAFRCTGAAGEEWRVRLEPVGIRLLSGGVAESGPDTAAVRGQAADLLLLLYGRRSYQETVFDVSGDATVLDRWFDHTAF
>CP033073|7900224:7954363|7929105_7929648_+|AYN43289.1|DBSCAN-SWA
MVTLETPRLILRRWREEDVAPMAAVNADPEVMRWIRDGSVRDEQQTRDGVQAWESEWESQGFGLFAVEIRSTGELAGFTGLSVPDFLPEVLPAVEVGWRLGRSHWGQGLATEAAAAAVRFGFEERGLERIVSITQVGNDASERIMTKLGMHPVRETVNPIGGRRVRVFELSSDQYVTTTR
>CP033073|7900224:7954363|7914868_7915675_+|AYN43279.1|DBSCAN-SWA
MSKDSDAAKAVLGQFPAALTETVSLATPLTLSRIEGRDQAVLVLRELAESFGIGEPEFVATDDQRAFVTFVGRGQGREVGLFAVLTRGSEGTYSAVDLYARPWPFVKLVRDHLAASDKRFHNDIDLSVPYVPAGPPGGFRTDTPGLPGLSADVAFHSPVLTDTAGGGGLVGVILMAVEEISGAPRFRVATRFGNASVVLYDATVHGHTWQLGLVIGLDGNDEIADMRVYSRPWPVAALFRGEVYKLLRDRLGPQYWQGENPLVALGEE
>CP033073|7900224:7954363|7905284_7905479_+|AYN43269.1|DBSCAN-SWA
MDEALSMVNLVADRDIAEAAHALDEQIWRFHILVRRGLTPEDNWLVLRGRVVAAQNDFITVARR
>CP033073|7900224:7954363|7950751_7951018_-|AYN43302.1|DBSCAN-SWA
MENDIADSMEPHPQEPRPRPARGTAFGLGAQEVGVDAPAEAFAACGVFGLTVEDWEQALGAAERGEGPPVDWGCSSSNVHGGTGEAGQ
>CP033073|7900224:7954363|7949354_7950161_-|AYN43301.1|DBSCAN-SWA
MSAAEGVSPSPGVRLEYHVAQNLALEAGDDLWFSLEGMPPGWDKVKVTSPALQEPITLTPLKKGSTQSVQVDAEGSEHRIRSGLRPGAYPVTATSHGRIVATATLKVAAENSAQIDRFVIGPRDAFPGSGTPASLRPGGDVRVVLTDLRAAPGENSLTVTSPIFKGPLTIKTNSPDNPGCKCDDAGTVYAGHARLRGDVPDGRYTVTVVSHHGQQTTTQHVTIAGQPVKDGGPSWAVAGGVAAAGLALASGGVFTVRRQRSRKAEPSA
>CP033073|7900224:7954363|7910562_7910754_-|AYN43275.1|DBSCAN-SWA
MTEWEINPAGVPRARHGTGRRFRQRTLALSEHPAFLCRLGGPFFLFQCKVTALGALRDPNEPL
>CP033073|7900224:7954363|7931168_7931642_+|AYN44050.1|DBSCAN-SWA
MIVIMGIHIAPAGVADFHEVLTDHSRYWGERDLRSLHLLALVQEFGSTCLIARAEDGIRGYVFGFVTPDGTAYVHLIATRDDARGTGLGRRLYAAFAEAAERHGARQLKAITSIENTGSIAFHRSLGFDTRIVDDYNGPGRAMAVFHRDLPLNVSCP
>CP033073|7900224:7954363|7911674_7912832_-|AYN43276.1|DBSCAN-SWA
MRRLFHAGVAAGAALVLTACGGGAADGGSGARAEGSGDGKKTADVKSASLAQSGSLTVAYCHEIPNGNSDPVYGLTLRSYSAKNGAVVGERSVVLPSDVEPETVCEEGSFRSLATFAFNKDMSLIAGITDAGETARAGAYDLTTGKEVSPPDPDAFTERATNKGVAFHPTTGLLWYDESDHESDDEGFGSRDARAGYSTEKHLNVSQAAAVVTQDAATTSTALAANAWPQAVTPSGDVAADLSDTPAYGPMLALYRVTSDGGSSGGYKLTDLTTKGLDGRETCAPTFWRDATTLVCGMQQITLASDYSRVVKNEDLVPANDRDNRTPVPSPDGKSFAFLSSGEGEKLTLYRGDLSSIGAQPVKVADLEPPLDGSDDHLATLVRWN
>CP033073|7900224:7954363|7905816_7906575_-|AYN43270.1|DBSCAN-SWA
MTGRLITVRRKAAPAGLLLVASAAAWVWVVTRQGGMQMVPGTMGLGLPAFLAVWTLMMAAMMLPATALVAALYARTMTVRRAPRMAAFTVAYLLVWAAAGLPAYGLAVGLGRAGHLPAGAGTVVAAAVFAINGAYQLTPLKDRCLARCRSPIWLVLRYTSYPGRSRDVRAGGHHGAFCLGCCWSLMVLLAVFGVMNLWAMVVLTGVITTEKLAPGGRLVARAVGIASIALAAVVFWVPAVAPGLTGSGMTRM
>CP033073|7900224:7954363|7926650_7927115_-|AYN43288.1|DBSCAN-SWA
MPDVTAPDGELVAREAAGRLAFEQLQNRLQRRGARAARAADEWPAHFVAVDLLRLSGTDTISWPYRRRRAALESVFAARRLIAPWVLCPPAIDPDTVRETTEAIVGALRGSRPTVRGKEFRSGGVEEWRGGRGRRDVTGSRRRRPTRSTVCSSR
>CP033073|7900224:7954363|7912984_7913254_-|AYN43277.1|DBSCAN-SWA
MKAGASRPTTRSGAPAAVVGTSAREKTYVKGYQVRTGPGTKYGSLGLILKYDGVEVRCKARTAGWMRVYVLNGQREGRTGWTAGKYIHD
>CP033073|7900224:7954363|7919591_7920008_+|AYN43284.1|transposase|DBSCAN-SWA
MGRRGRLHHRPGPPARRRGPSKGAPVGEPPDHALGRSRGGLTTTKIHLAVGGHCRPLAFVITPGQSGDAPAFTQVMTRLRVPRRIGRPRITPDILADKAYSSRAIRSHLRRRGIRAVIPQPADQAANRKRLGSRGGTA
>CP033073|7900224:7954363|7951872_7952226_+|AYN43303.1|DBSCAN-SWA
MSLCPATTDRAAAGDWLHPAWGAAGVEGVIVKGRAQAYRPGRRGWIKVRARTTAEGLIVAVTGTVQEPNTLLLGRYDTAARLRLVARTAPPSPRARSVVRPVPTGRGSRTVPPSRGM
>CP033073|7900224:7954363|7908500_7908971_+|AYN43273.1|DBSCAN-SWA
MKLAEALAERAEATRRVEQLRARVVSSARYQEGETPAEDAAQLLAEAGEVLNALETLIRRINRTNATVEMGPDGPLTDALARRDVLRSRHSVVTAAADAAAGQGERGYGRQLRSELMMLSALPVAELRGQADALAREIREVDVRIQRTNWEVDLLD
>CP033073|7900224:7954363|7932292_7933159_+|AYN43290.1|DBSCAN-SWA
MTTSLKENIGRYGVWSGELRSEDPARRGELDEAAAELEELGYGAVWLGGNSTVDHAAPLIGATRRITVGTSIQSVWQQDAATTAAGFTEIETAHPGRFMLGLGVSHGPLVKNYQRPFAAMTGYLGELDTAGVPADRRVLAALGPRMLALSGDRAAGAIPYLVTPEHTARAREILGEGPLLAPEFKVVLETDPARARETARAYLARYLELPNYTDNFLRLGFTEADVAAGGSDRLIDAVFAWGGETRIRERVAAFHEAGADHVALQVVTDGTDGTLPREEWRRLASLLA
>CP033073|7900224:7954363|7936070_7936472_-|AYN44051.1|DBSCAN-SWA
MVPSAERLRTSAICVTENVEHTLGRTGEVDDVVQAFVAEPGRADRLRAAARGLAECAEGPAGCPPLYGIPVWVKNSVHVDGLPIRAGSALWADLLTGRRAAVVDRLLEAGAVIAGKTVTAEFAVAVPAPCRRR
>CP033073|7900224:7954363|7945155_7945908_-|AYN43298.1|DBSCAN-SWA
MTERRAVLSGSTFEEQIGYARAVVDGDWVHVSGTTGFDYATMTISDDAAEQAEQCLRNIEAALAEAKCTIADVVRVRYLLPDREDFEPCWPVLRSYFGDVRPAATMLMCGLADPRMKIEIEVYARRRIPPYGGAMSNRSEAPVAPVGSYEPPYYVAVFTTVRTQDQSGYSETDARLEDLVKDVPGYLGMDHAQTPGGLGITVGYFRDADALTEWRTNAEHRAAQKRGRAEWYQSYTLHVAKVERSNGFTH
>CP033073|7900224:7954363|7916029_7916518_+|AYN43280.1|DBSCAN-SWA
MGASGAAAAAPLPERRRRYPGRLRVPDRAALAGVMYVLRTGVAWRDVPARAWAALQSRPGAGCGTGPRPASRPACTPPCWPSWQADLLGMDDCAVDGSHVSAPQGLLELACSIICLRRLRTSFRNDILSVQVRARPLAPPTPTRGSTASRLWACRRPFVCGP
>CP033073|7900224:7954363|7924193_7924523_-|AYN43286.1|DBSCAN-SWA
MKDITVGEAIDHLRAELTAARDRAVNSGLHFELGDISLEFTVELRREQSGKGSIKAWVVSGEAGAVKSGTAAHRLAFTLRAVDQDGAGIRIGNSDAPTGGLTGGGGLVR
>CP033073|7900224:7954363|7943407_7944094_+|AYN43297.1|transposase|DBSCAN-SWA
MILVADPRDGRGLRYPAVALLCAAVSAVLAGARSLIATSEWITDAPQYALGVLGFAADPLTGLRPVPHAAAVRRLLQRETVMRRTRRSALFCRPEPHPRPIRRRRRGRRRVIAVDGNVLRGSRTKTPTAVQTAGCDGPLRRGPGPRVHAARLPGALAHRRTGRGGCRGQDTVRPAVTSPSSRAVAAPRGRDTGAPVGLHVDLHGGCVVFARVPGRGCPRPSARPPEHP
>CP033073|7900224:7954363|7936548_7937178_-|AYN43293.1|DBSCAN-SWA
MTEHTKHSDEMKRITPVSSSGREVRVCDDDRNHAAERVRAAVVNGRLEISELDERLAAVYAARTMGELEAAGRGLPEPGPRDALVVDRVPTSRFALGMFGGFEREGEWVVPPKFTAWSIWGGGRLDLSEARFAEQETVIRAVALWGGTEIVVPDDIEVKVEGFGLFGVFGKRGARKIGKSGTPRVVIKGIAVFGGVVTKSKPVASPPQR

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYN43265.1|7900224_7902375_-|protease	serine protease	NA	NA	NA	NA
AYN43266.1|7902378_7902774_-	hypothetical protein	NA	NA	NA	NA
AYN43267.1|7902858_7903080_-	hypothetical protein	NA	NA	NA	NA
AYN43268.1|7903505_7904324_-	maleylpyruvate isomerase family mycothiol-dependent enzyme	NA	NA	NA	NA
AYN43269.1|7905284_7905479_+	hypothetical protein	NA	NA	NA	NA
AYN43270.1|7905816_7906575_-	DUF2182 domain-containing protein	NA	NA	NA	NA
AYN43271.1|7906571_7907186_-	DUF1326 domain-containing protein	NA	NA	NA	NA
AYN43272.1|7908262_7908514_+	hypothetical protein	NA	NA	NA	NA
AYN43273.1|7908500_7908971_+	hypothetical protein	NA	NA	NA	NA
AYN43274.1|7909542_7910376_+	GlcNAc-PI de-N-acetylase	NA	NA	NA	NA
AYN43275.1|7910562_7910754_-	hypothetical protein	NA	NA	NA	NA
AYN43276.1|7911674_7912832_-	hypothetical protein	NA	NA	NA	NA
AYN43277.1|7912984_7913254_-	hypothetical protein	NA	NA	NA	NA
AYN43278.1|7913559_7914351_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
AYN43279.1|7914868_7915675_+	hypothetical protein	NA	NA	NA	NA
AYN43280.1|7916029_7916518_+	hypothetical protein	NA	NA	NA	NA
AYN43281.1|7916538_7917156_-	glyoxalase	NA	NA	NA	NA
AYN43282.1|7917429_7917990_-	hypothetical protein	NA	NA	NA	NA
AYN43283.1|7919415_7919715_+|transposase	transposase	A0A0N9SHJ4	Paenibacillus_phage	2.8e-09	35.4
AYN43284.1|7919591_7920008_+|transposase	IS4/IS5 family transposase	NA	NA	NA	NA
AYN43285.1|7920157_7924156_-	hypothetical protein	NA	NA	NA	NA
AYN43286.1|7924193_7924523_-	hypothetical protein	NA	NA	NA	NA
AYN43287.1|7924574_7926266_-	hypothetical protein	NA	NA	NA	NA
AYN43288.1|7926650_7927115_-	ATP-dependent DNA ligase	NA	NA	NA	NA
AYN43289.1|7929105_7929648_+	N-acetyltransferase	NA	NA	NA	NA
AYN44050.1|7931168_7931642_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
AYN43290.1|7932292_7933159_+	LLM class F420-dependent oxidoreductase	NA	NA	NA	NA
AYN43291.1|7934242_7934677_-	hypothetical protein	NA	NA	NA	NA
AYN43292.1|7934899_7935880_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
AYN44051.1|7936070_7936472_-	hypothetical protein	NA	NA	NA	NA
AYN43293.1|7936548_7937178_-	DUF1707 and DUF2154 domain-containing protein	NA	NA	NA	NA
7938953:7938971	attL	NA	NA	NA	NA
AYN43294.1|7940657_7941572_-|transposase	IS982 family transposase	NA	NA	NA	NA
AYN44052.1|7941626_7942031_-	SgcJ/EcaC family oxidoreductase	NA	NA	NA	NA
AYN43295.1|7942154_7942679_-	PadR family transcriptional regulator	NA	NA	NA	NA
AYN43296.1|7942773_7943325_+	hypothetical protein	NA	NA	NA	NA
AYN43297.1|7943407_7944094_+|transposase	transposase family protein	NA	NA	NA	NA
AYN43298.1|7945155_7945908_-	hypothetical protein	NA	NA	NA	NA
AYN43299.1|7945980_7946889_+	LysR family transcriptional regulator	NA	NA	NA	NA
AYN44053.1|7947249_7948716_-	hypothetical protein	NA	NA	NA	NA
AYN43300.1|7948900_7949137_+	hypothetical protein	NA	NA	NA	NA
AYN43301.1|7949354_7950161_-	hypothetical protein	NA	NA	NA	NA
AYN43302.1|7950751_7951018_-	hypothetical protein	NA	NA	NA	NA
AYN43303.1|7951872_7952226_+	hypothetical protein	NA	NA	NA	NA
AYN43304.1|7953166_7954363_+|integrase	integrase	NA	NA	NA	NA
7960036:7960054	attR	NA	NA	NA	NA