CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP033199	Streptococcus mutans strain LAB761 chromosome, complete genome	2 crisprs	RT,WYL,csa3,cas3,cas8e,cse2gr11,cas7,cas5,cas1,DEDDh,cas9,cas2,csn2,DinG,csm6	1	25	6	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP033199_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP033199_1

364119-365917

TypeI-E

Consensus_repeat	Method
ATTTTACCCGCACGAGCGGGGGTGATCC	PILER-CR
ATTTTACCCGCACGAGCGGGGGTGATCC	CRISPRCasFinder
ATTTTACCCGCACGAGCGGGGGTGATCC	CRT

29 spacers

DEDDh,cas1,cas5,cas7,cse2gr11,cas8e,cas3,WYL

The CRISPR arrays of CP033199_1

>merge|CP033199|1|364119-365917|PILER-CR,CRISPRCasFinder,CRT
ATTTTACCCGCACGAGCGGGGGTGATCCCTAATAAAAAACGTTCAAATGGTTTATGGTATAATTTTACCCGCACGAGCGGGGGTGATCCCTGCAATGCAAGAGCTGATAAATGAAAAACATAATTTTACCCGCACGAGCGGGGGTGATCCTTAAATTGAGCCCGCTAGTAAATGCGCTAGAAAATTTTACCCGCACGAGCGGGGGTGATCCTACTGTAGATTACACTCGCGGACCATTCACTGGATTTTACCCGCACGAGCGGGGGTGATCCCGAGTGCTTGAAATCCAGCAAAAACTCGAGCAAATTTTACCCGCACGAGCGGGGGTGATCCCTCCGCTGAGAAATACACGATTATACATCTCATATTTTACCCGCACGAGCGGGGGTGATCCACGTTTTGCAGTTGGAAAAATCACTGACAACAAATTTTACCCGCACGAGCGGGGGTGATCCCTACTAGAGCAGGGGACTTCATCAGATGATTTTATTTTACCCGCACGAGCGGGGGTGATCCTTGCGGTAATCAATAAAGGAAAATAATGCTTAAATTTTACCCGCACGAGCGAGGGTGATCCTGCAGTTGACGCGCCGCTTGCTAAGAATAAATAATTTTACCCGCACGAGCGGGGGTGATCCCGGGAAATTACTGTATGGAGTAGAAACGCTTAAATTTTACCCGCACGAGCGGGGGTGATCCTAGCTTCGAAGCTAAAACGCACGCGCAAAAAGAATTTTACCCGCACGAGCGGGGGTGATCCTTACATTTCCTGCAAAGGTCCCAAGGAAAGAACATTTTACCCGCACGAGCGGGGGTGATCCATGGAAAGCGCAAGAAAGAGCGCTTGAACAATCCATTTTACCCGCACGAGCGGGGGTGATCCTTGAGGAAATACAGTCTTTGACTGAGTCACGACATTTTACCCGCACGAGCGGGGGTGATCCTACAATCTCTAACTGAGTCTAGATTAACAATTAATTTTACCCGCACGAGCGGGGGTGATCCTATAGTTGATAGCCGCTAACAAGTTATCATAGCATTTTACCCGCACGAGCGGGGGTGATCCCGGACACACAGGTAAGGTTAGGTAAGGATAGATATTTTACCCGCACGAGCGGGGGTGATCCTTTGGTTATTAGTCTTGTAATCATCTGCTTGTGATTTTACCCGCACGAGCGGGGGTGATCCTAACGCAGGTCAAGCAGAAAGTAAGTTCCATCAATTTTACCCGCACGAGCGGGGGTGATCCTGTGTCGACATTGACACAGACTTAACTGATAACATTTTACCCGCACGAGCGGGGGTGATCCTGGTTTTAGGTCTATCTGCTAGTTTATTGATTGATTTTACCCGCACGAGCGGGGGTGATCCCTGACTCAAGAGGTATGCGGTCCGACGCAGTCAATTTTACCCGCACGAGCGGGGGTGATCCCGCAGAATATTACATTTTTCAAGTGATGAAGCAATTTTACCCGCACGAGCGGGGGTGATCCTACGTTTCGATCTAGGCGTTTACAAATCTGCAAATTTTACCCGCACGAGCGGGGGTGATCCTAATAAGCCAGCCGATAGTCCTAAAATTGTTAAATTTTACCCGCACGAGCGGGGGTGATCCTACGACAATATTTAGCTGGTGTGAATTTTTGAGATTTTACCCGCACGAGCGGGGGTGATCCATGGAAAGCGCAAGAAAGAGCGCTTGAACAATCCATTTTACCCGCACGAGCGGGGGTGATCCTTGAGGAAATACAGTCTTTGACTGAGTCACGACATTTTACCCGCACGAGCGGGGGTGATCC

>CP033199|1|1|364119-365917|PILER-CR
ATTTTACCCGCACGAGCGGGGGTGATCC	CTAATAAAAAACGTTCAAATGGTTTATGGTATA
ATTTTACCCGCACGAGCGGGGGTGATCC	CTGCAATGCAAGAGCTGATAAATGAAAAACATA
ATTTTACCCGCACGAGCGGGGGTGATCC	TTAAATTGAGCCCGCTAGTAAATGCGCTAGAAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TACTGTAGATTACACTCGCGGACCATTCACTGG
ATTTTACCCGCACGAGCGGGGGTGATCC	CGAGTGCTTGAAATCCAGCAAAAACTCGAGCAA
ATTTTACCCGCACGAGCGGGGGTGATCC	CTCCGCTGAGAAATACACGATTATACATCTCAT
ATTTTACCCGCACGAGCGGGGGTGATCC	ACGTTTTGCAGTTGGAAAAATCACTGACAACAA
ATTTTACCCGCACGAGCGGGGGTGATCC	CTACTAGAGCAGGGGACTTCATCAGATGATTTT
ATTTTACCCGCACGAGCGGGGGTGATCC	TTGCGGTAATCAATAAAGGAAAATAATGCTTAA
ATTTTACCCGCACGAGCGAGGGTGATCC	TGCAGTTGACGCGCCGCTTGCTAAGAATAAATA
ATTTTACCCGCACGAGCGGGGGTGATCC	CGGGAAATTACTGTATGGAGTAGAAACGCTTAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TAGCTTCGAAGCTAAAACGCACGCGCAAAAAGA
ATTTTACCCGCACGAGCGGGGGTGATCC	TTACATTTCCTGCAAAGGTCCCAAGGAAAGAAC
ATTTTACCCGCACGAGCGGGGGTGATCC	ATGGAAAGCGCAAGAAAGAGCGCTTGAACAATCC
ATTTTACCCGCACGAGCGGGGGTGATCC	TTGAGGAAATACAGTCTTTGACTGAGTCACGAC
ATTTTACCCGCACGAGCGGGGGTGATCC	TACAATCTCTAACTGAGTCTAGATTAACAATTA
ATTTTACCCGCACGAGCGGGGGTGATCC	TATAGTTGATAGCCGCTAACAAGTTATCATAGC
ATTTTACCCGCACGAGCGGGGGTGATCC	CGGACACACAGGTAAGGTTAGGTAAGGATAGAT
ATTTTACCCGCACGAGCGGGGGTGATCC	TTTGGTTATTAGTCTTGTAATCATCTGCTTGTG
ATTTTACCCGCACGAGCGGGGGTGATCC	TAACGCAGGTCAAGCAGAAAGTAAGTTCCATCA
ATTTTACCCGCACGAGCGGGGGTGATCC	TGTGTCGACATTGACACAGACTTAACTGATAAC
ATTTTACCCGCACGAGCGGGGGTGATCC	TGGTTTTAGGTCTATCTGCTAGTTTATTGATTG
ATTTTACCCGCACGAGCGGGGGTGATCC	CTGACTCAAGAGGTATGCGGTCCGACGCAGTCA
ATTTTACCCGCACGAGCGGGGGTGATCC	CGCAGAATATTACATTTTTCAAGTGATGAAGCA
ATTTTACCCGCACGAGCGGGGGTGATCC	TACGTTTCGATCTAGGCGTTTACAAATCTGCAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TAATAAGCCAGCCGATAGTCCTAAAATTGTTAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TACGACAATATTTAGCTGGTGTGAATTTTTGAG
ATTTTACCCGCACGAGCGGGGGTGATCC	ATGGAAAGCGCAAGAAAGAGCGCTTGAACAATCC
ATTTTACCCGCACGAGCGGGGGTGATCC	TTGAGGAAATACAGTCTTTGACTGAGTCACGAC
ATTTTACCCGCACGAGCGGGGGTGATCC

>CP033199|1|1|364119-365917|CRISPRCasFinder
ATTTTACCCGCACGAGCGGGGGTGATCC	CTAATAAAAAACGTTCAAATGGTTTATGGTATA
ATTTTACCCGCACGAGCGGGGGTGATCC	CTGCAATGCAAGAGCTGATAAATGAAAAACATA
ATTTTACCCGCACGAGCGGGGGTGATCC	TTAAATTGAGCCCGCTAGTAAATGCGCTAGAAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TACTGTAGATTACACTCGCGGACCATTCACTGG
ATTTTACCCGCACGAGCGGGGGTGATCC	CGAGTGCTTGAAATCCAGCAAAAACTCGAGCAA
ATTTTACCCGCACGAGCGGGGGTGATCC	CTCCGCTGAGAAATACACGATTATACATCTCAT
ATTTTACCCGCACGAGCGGGGGTGATCC	ACGTTTTGCAGTTGGAAAAATCACTGACAACAA
ATTTTACCCGCACGAGCGGGGGTGATCC	CTACTAGAGCAGGGGACTTCATCAGATGATTTT
ATTTTACCCGCACGAGCGGGGGTGATCC	TTGCGGTAATCAATAAAGGAAAATAATGCTTAA
ATTTTACCCGCACGAGCGAGGGTGATCC	TGCAGTTGACGCGCCGCTTGCTAAGAATAAATA
ATTTTACCCGCACGAGCGGGGGTGATCC	CGGGAAATTACTGTATGGAGTAGAAACGCTTAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TAGCTTCGAAGCTAAAACGCACGCGCAAAAAGA
ATTTTACCCGCACGAGCGGGGGTGATCC	TTACATTTCCTGCAAAGGTCCCAAGGAAAGAAC
ATTTTACCCGCACGAGCGGGGGTGATCC	ATGGAAAGCGCAAGAAAGAGCGCTTGAACAATCC
ATTTTACCCGCACGAGCGGGGGTGATCC	TTGAGGAAATACAGTCTTTGACTGAGTCACGAC
ATTTTACCCGCACGAGCGGGGGTGATCC	TACAATCTCTAACTGAGTCTAGATTAACAATTA
ATTTTACCCGCACGAGCGGGGGTGATCC	TATAGTTGATAGCCGCTAACAAGTTATCATAGC
ATTTTACCCGCACGAGCGGGGGTGATCC	CGGACACACAGGTAAGGTTAGGTAAGGATAGAT
ATTTTACCCGCACGAGCGGGGGTGATCC	TTTGGTTATTAGTCTTGTAATCATCTGCTTGTG
ATTTTACCCGCACGAGCGGGGGTGATCC	TAACGCAGGTCAAGCAGAAAGTAAGTTCCATCA
ATTTTACCCGCACGAGCGGGGGTGATCC	TGTGTCGACATTGACACAGACTTAACTGATAAC
ATTTTACCCGCACGAGCGGGGGTGATCC	TGGTTTTAGGTCTATCTGCTAGTTTATTGATTG
ATTTTACCCGCACGAGCGGGGGTGATCC	CTGACTCAAGAGGTATGCGGTCCGACGCAGTCA
ATTTTACCCGCACGAGCGGGGGTGATCC	CGCAGAATATTACATTTTTCAAGTGATGAAGCA
ATTTTACCCGCACGAGCGGGGGTGATCC	TACGTTTCGATCTAGGCGTTTACAAATCTGCAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TAATAAGCCAGCCGATAGTCCTAAAATTGTTAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TACGACAATATTTAGCTGGTGTGAATTTTTGAG
ATTTTACCCGCACGAGCGGGGGTGATCC	ATGGAAAGCGCAAGAAAGAGCGCTTGAACAATCC
ATTTTACCCGCACGAGCGGGGGTGATCC	TTGAGGAAATACAGTCTTTGACTGAGTCACGAC
ATTTTACCCGCACGAGCGGGGGTGATCC

>CP033199|1|1|364119-365917|CRT
ATTTTACCCGCACGAGCGGGGGTGATCC	CTAATAAAAAACGTTCAAATGGTTTATGGTATA
ATTTTACCCGCACGAGCGGGGGTGATCC	CTGCAATGCAAGAGCTGATAAATGAAAAACATA
ATTTTACCCGCACGAGCGGGGGTGATCC	TTAAATTGAGCCCGCTAGTAAATGCGCTAGAAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TACTGTAGATTACACTCGCGGACCATTCACTGG
ATTTTACCCGCACGAGCGGGGGTGATCC	CGAGTGCTTGAAATCCAGCAAAAACTCGAGCAA
ATTTTACCCGCACGAGCGGGGGTGATCC	CTCCGCTGAGAAATACACGATTATACATCTCAT
ATTTTACCCGCACGAGCGGGGGTGATCC	ACGTTTTGCAGTTGGAAAAATCACTGACAACAA
ATTTTACCCGCACGAGCGGGGGTGATCC	CTACTAGAGCAGGGGACTTCATCAGATGATTTT
ATTTTACCCGCACGAGCGGGGGTGATCC	TTGCGGTAATCAATAAAGGAAAATAATGCTTAA
ATTTTACCCGCACGAGCGAGGGTGATCC	TGCAGTTGACGCGCCGCTTGCTAAGAATAAATA
ATTTTACCCGCACGAGCGGGGGTGATCC	CGGGAAATTACTGTATGGAGTAGAAACGCTTAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TAGCTTCGAAGCTAAAACGCACGCGCAAAAAGA
ATTTTACCCGCACGAGCGGGGGTGATCC	TTACATTTCCTGCAAAGGTCCCAAGGAAAGAAC
ATTTTACCCGCACGAGCGGGGGTGATCC	ATGGAAAGCGCAAGAAAGAGCGCTTGAACAATCC
ATTTTACCCGCACGAGCGGGGGTGATCC	TTGAGGAAATACAGTCTTTGACTGAGTCACGAC
ATTTTACCCGCACGAGCGGGGGTGATCC	TACAATCTCTAACTGAGTCTAGATTAACAATTA
ATTTTACCCGCACGAGCGGGGGTGATCC	TATAGTTGATAGCCGCTAACAAGTTATCATAGC
ATTTTACCCGCACGAGCGGGGGTGATCC	CGGACACACAGGTAAGGTTAGGTAAGGATAGAT
ATTTTACCCGCACGAGCGGGGGTGATCC	TTTGGTTATTAGTCTTGTAATCATCTGCTTGTG
ATTTTACCCGCACGAGCGGGGGTGATCC	TAACGCAGGTCAAGCAGAAAGTAAGTTCCATCA
ATTTTACCCGCACGAGCGGGGGTGATCC	TGTGTCGACATTGACACAGACTTAACTGATAAC
ATTTTACCCGCACGAGCGGGGGTGATCC	TGGTTTTAGGTCTATCTGCTAGTTTATTGATTG
ATTTTACCCGCACGAGCGGGGGTGATCC	CTGACTCAAGAGGTATGCGGTCCGACGCAGTCA
ATTTTACCCGCACGAGCGGGGGTGATCC	CGCAGAATATTACATTTTTCAAGTGATGAAGCA
ATTTTACCCGCACGAGCGGGGGTGATCC	TACGTTTCGATCTAGGCGTTTACAAATCTGCAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TAATAAGCCAGCCGATAGTCCTAAAATTGTTAA
ATTTTACCCGCACGAGCGGGGGTGATCC	TACGACAATATTTAGCTGGTGTGAATTTTTGAG
ATTTTACCCGCACGAGCGGGGGTGATCC	ATGGAAAGCGCAAGAAAGAGCGCTTGAACAATCC
ATTTTACCCGCACGAGCGGGGGTGATCC	TTGAGGAAATACAGTCTTTGACTGAGTCACGAC
ATTTTACCCGCACGAGCGGGGGTGATCC

Protein	Signature genes	Signature genes Name	Protein_function
CP033199.1\|AYO47361.1\|369446_373085_+\|helicase-exonuclease-AddAB-subunit-AddA	unknown	unknown	gnl\|CDD\|274299
CP033199.1\|AYO47357.1\|360885_361602_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	cas5	cd09756_cas5_CAS-I-E	gnl\|CDD\|187886
CP033199.1\|AYO47363.1\|374371_374800_+\|galactose-6-phosphate-isomerase-subunit-LacA	unknown	unknown	gnl\|CDD\|181505
CP033199.1\|AYO47354.1\|354612_357399_+\|CRISPR-associated-helicase/endonuclease-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|182031
CP033199.1\|AYO47351.1\|352028_352355_+\|hypothetical-protein	unknown	unknown	unknown
CP033199.1\|AYO47359.1\|363192_364095_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|176648
CP033199.1\|AYO48819.1\|359073_359670_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	cse2gr11	mkCas0194_cse2gr11_CAS-I-E	gnl\|CDD\|378191
CP033199.1\|AYO47369.1\|379328_380735_+\|6-phospho-beta-galactosidase	unknown	unknown	gnl\|CDD\|184102
CP033199.1\|AYO47362.1\|373309_374065_+\|DeoR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
CP033199.1\|AYO47360.1\|366214_369457_+\|ATP-dependent-nuclease-subunit-B	unknown	unknown	gnl\|CDD\|274291
CP033199.1\|AYO47355.1\|357391_359074_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	cas8e	cd09729_cas8e_CAS-I-E	gnl\|CDD\|378189
CP033199.1\|AYO47365.1\|375359_376292_+\|tagatose-6-phosphate-kinase	unknown	unknown	gnl\|CDD\|273515
CP033199.1\|AYO47368.1\|377610_379317_+\|PTS-lactose-transporter-subunit-IIBC	unknown	unknown	gnl\|CDD\|273055
CP033199.1\|AYO47352.1\|352529_352775_+\|hypothetical-protein	unknown	unknown	unknown
CP033199.1\|AYO47367.1\|377289_377604_+\|lactose-specific-phosphotransferase-enzyme-IIA-component	unknown	unknown	gnl\|CDD\|129903
CP033199.1\|AYO47364.1\|374825_375341_+\|galactose-6-phosphate-isomerase-subunit-LacB	unknown	unknown	gnl\|CDD\|181506
CP033199.1\|AYO47353.1\|353439_354423_+\|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl\|CDD\|379100
CP033199.1\|AYO47358.1\|362249_363191_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	cas1	cd09719_cas1_CAS-I-E	gnl\|CDD\|274693
CP033199.1\|AYO47356.1\|359659_360880_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	cas7	pfam09344_cas7_CAS-I-E	gnl\|CDD\|378153
CP033199.1\|AYO47366.1\|376296_377274_+\|tagatose-1,6-diphosphate-aldolase	unknown	unknown	gnl\|CDD\|183502

Protein	Function_ID	Function_description	E-value
CP033199.1\|AYO47361.1\|369446_373085_+\|helicase-exonuclease-AddAB-subunit-AddA	gnl\|CDD\|274299	TIGR02785, ATP-dependent_helicase/nuclease_subunit_A, helicase-exonuclease AddAB, AddA subunit, Firmicutes type. AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair].	0
CP033199.1\|AYO47357.1\|360885_361602_+\|type-I-E-CRISPR-associated-protein-Cas5/CasD	gnl\|CDD\|187886	cd09756, Cas5_I-E, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex.	5.58758e-44
CP033199.1\|AYO47363.1\|374371_374800_+\|galactose-6-phosphate-isomerase-subunit-LacA	gnl\|CDD\|181505	PRK08621, PRK08621, galactose-6-phosphate isomerase subunit LacA; Reviewed.	3.84241e-90
CP033199.1\|AYO47354.1\|354612_357399_+\|CRISPR-associated-helicase/endonuclease-Cas3	gnl\|CDD\|182031	PRK09694, PRK09694, CRISPR-associated helicase/endonuclease Cas3.	2.2268e-94
CP033199.1\|AYO47362.1\|373309_374065_+\|DeoR-family-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	2.81514e-78
CP033199.1\|AYO47359.1\|363192_364095_+\|type-I-E-CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|176648	cd06127, DEDDh, DEDDh 3'-5' exonuclease domain family. DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved sequence motifs termed ExoI, ExoII and ExoIII. DEDDh exonucleases are classified as such because of the presence of specific Hx(4)D conserved pattern at the ExoIII motif. The four conserved acidic residues are clustered around the active site and serve as ligands for the two metal ions required for catalysis. Most DEDDh exonucleases are the proofreading subunits (epsilon) or domains of bacterial DNA polymerase III, the main replicating enzyme in bacteria, which functions as the chromosomal replicase. Other members include other DNA and RNA exonucleases such as RNase T, Oligoribonuclease, and RNA exonuclease (REX), among others.	1.6238e-41
CP033199.1\|AYO48819.1\|359073_359670_+\|type-I-E-CRISPR-associated-protein-Cse2/CasB	gnl\|CDD\|378191	pfam09485, CRISPR_Cse2, CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	2.86292e-38
CP033199.1\|AYO47369.1\|379328_380735_+\|6-phospho-beta-galactosidase	gnl\|CDD\|184102	PRK13511, PRK13511, 6-phospho-beta-galactosidase; Provisional.	0
CP033199.1\|AYO47360.1\|366214_369457_+\|ATP-dependent-nuclease-subunit-B	gnl\|CDD\|274291	TIGR02774, putative_ATP-dependent_exonuclease_subunit_B, ATP-dependent nuclease subunit B. DNA repair is accomplished by several different systems in prokaryotes. Recombinational repair of double-stranded DNA breaks involves the RecBCD pathway in some lineages, and AddAB (also called RecAB) in other. The AddA protein is conserved between the firmicutes and the alphaproteobacteria, while the partner protein is not. The partner may be designated AddB, as in Bacillus and in alphaproteobacteria, or RexB as in Streptococcus and Lactococcus. Note, however, that RexB proteins lack an N-terminal GxxGxGK[ST] ATP-binding motif found in Bacillus subtilis and related species, and this difference may be important; this model represents specifically RexB proteins as found in Streptococcus and Lactococcus. [DNA metabolism, DNA replication, recombination, and repair].	0
CP033199.1\|AYO47355.1\|357391_359074_+\|type-I-E-CRISPR-associated-protein-Cse1/CasA	gnl\|CDD\|378189	pfam09481, CRISPR_Cse1, CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	1.23246e-84
CP033199.1\|AYO47365.1\|375359_376292_+\|tagatose-6-phosphate-kinase	gnl\|CDD\|273515	TIGR01231, Tagatose-6-phosphate_kinase, tagatose-6-phosphate kinase. This enzyme is part of the tagatose-6-phosphate pathway of lactose degradation. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
CP033199.1\|AYO47368.1\|377610_379317_+\|PTS-lactose-transporter-subunit-IIBC	gnl\|CDD\|273055	TIGR00394, lac_pts_IIC, phosphotransferase system, lactose specific, IIC component. This family of proteins models the IIC domain of the phosphotransferase system (PTS) for lactose. The IIC domain catalyzes the transfer of a phosphoryl group from the IIB domain to lactose. When the IIC component and IIB components are in the same polypeptide chain they are designated IIBC. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS].	0
CP033199.1\|AYO47367.1\|377289_377604_+\|lactose-specific-phosphotransferase-enzyme-IIA-component	gnl\|CDD\|129903	TIGR00823, PTS_system_lactose-specific_IIA_component, phosphotransferase system enzyme II, lactose-specific, factor III. The PTS Lactose-N,N?-Diacetylchitobiose-b-glucoside (Lac) Family (TC 4.A.3)Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains.The Lac family includes several sequenced lactose (b-galactoside) permeases of Gram-positive bacteria as well as the E. coli N,N?-diacetylchitobiose (Chb)permease which can transport aromatic b-glucosides and cellobiose as well as the chitin disaccharide, Chb, but only Chb induces expression of the chboperon. While the Lac permeases consist of two polypeptide chains (IIA and IICB), the Chb permease of E. coli consists of three (IIA, IIB and IIC). In B. subtilis, a PTS permease similar to the Chb permease of E. coli is believed to transport lichenan (a b-1,3;1,4 glucan) degradation products, oligosaccharides of 2-4 glucose units. This model is specific for the IIA subunit of the Lac PTS family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	9.66453e-45
CP033199.1\|AYO47364.1\|374825_375341_+\|galactose-6-phosphate-isomerase-subunit-LacB	gnl\|CDD\|181506	PRK08622, PRK08622, galactose-6-phosphate isomerase subunit LacB; Reviewed.	8.58673e-124
CP033199.1\|AYO47353.1\|353439_354423_+\|WYL-domain-containing-protein	gnl\|CDD\|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	6.24343e-10
CP033199.1\|AYO47358.1\|362249_363191_+\|type-I-E-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274693	TIGR03638, cas1_ECOLI, CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes the Cas1 protein particular to the ECOLI subtype of CRISPR/Cas system.	8.18423e-132
CP033199.1\|AYO47356.1\|359659_360880_+\|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC	gnl\|CDD\|378153	pfam09344, Cas_CT1975, CT1975-like protein. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	6.15499e-145
CP033199.1\|AYO47366.1\|376296_377274_+\|tagatose-1,6-diphosphate-aldolase	gnl\|CDD\|183502	PRK12399, PRK12399, tagatose 1,6-diphosphate aldolase; Reviewed.	0

>CP033199.1|AYO47359.1|363192_364095_+|type-I-E-CRISPR-associated-endoribonuclease-Cas2
MPLTVITVKNAPPSLRGDLTKWMQEIATGVYVGNFNTKVREQLWNRVKDSVSNGEATLSFAYRNEIGYCFDTMNAQRKVVDFEGIPLVQLPNSNNNIKEEMNLGFSHAAKFRKIRRYSSHSKNNSPSLVPYVVIDIETDGLDENENSIIEIGAVKIGPSQLEEFNYLVKYDKILPKQISKLTGISQELLDRDGKDLQVVLQEFLNFIGNHDLVGYGINFDIKFINKKLKELNQPLLKNRVYDLMQYAKKEKLFLDNYKLQTVLKAYEIEDEVPHRALHDSKLIYDLSTKMNKFLKGINQK
>CP033199.1|AYO47358.1|362249_363191_+|type-I-E-CRISPR-associated-endonuclease-Cas1
MKEKFGAKKTSLKELPKISDRVSFIYVEHAKINRVDSAITVSDSNGTVRIPAAMLGVLLLGPGTDISHRAVELIGDTGTSIVWIGERGVRQYAHGRALAHSTKFLEKQARLVSNSRSRLKVARKMYQMRFPNEDVSSLTMQQLRGREGARIRKVYRLQSKKYKVPWTKREYSPDNFEDGTAVNQSLSAANVALYGLVHSIVVALGASPGLGFVHTGHDLSFVYDVADLYKAEFTIPIAFEVAANHEIGDDIGRITRLKIRDSFVDGKLMARIVKDIQYLLDIEAEDELLIDILALWDDREKLVKHGVSYKENS
>CP033199.1|AYO47357.1|360885_361602_+|type-I-E-CRISPR-associated-protein-Cas5/CasD
MKTILLKFAGPLQSWGTSSHFETRHTDFYPSKSAVIGMIAASLGYRRNEDEKIRKLNELDFAVRVDQQRNLLRDWHNAKSDKRKDPYTTNRYYLEDAVFVVAISHQNYAFIQMIEDGLRSPYFQPFMGRRACPLPVDFIVQVTNDSALDSLKQLDWQASAWYMKRQSTDDRISLEIYTDSYLTGKESYQLRQDKVLSFSQKERKFGFRYESRVRVEVLNPLWQEQSSTEHDIFNSIGD
>CP033199.1|AYO47356.1|359659_360880_+|type-I-E-CRISPR-associated-protein-Cas7/Cse4/CasC
MTTNQEKLFLDIHVIQTLPPSNINRDDTGGPKTAQYGGVRRARVSSQSWKRAMREYLVNSLKLENTSARTVKIVEYIAKQIQLIDQSIEIDTAKKLVKEMLERVVKKKSGKDEKIFVIDNEYKLSALFFISKFQSIKLAELALNPEFVEICNKFDALSGKVKEDKEYKKSKEYKEIDAAYKIQMKKIKEILNELLSIDIAFFGRMLASDPSLNEDASSQVAHAISTHAIQTEFDFFTAIDDLAPEDNAGAGMLGTVEFNSSTLYRYANIAIHELESQLDDGESAVNALKLFVEAFAKSLPTGKVNTFANQTLPQALVVTVRNDRPVNLVSAFEEPVKSSNGYVTKSIEKLSKEFVKVEKMVKKPVLSFYVSLEEVEALTKVGIEKNSITELVEDFSQELSELIQNR
>CP033199.1|AYO48819.1|359073_359670_+|type-I-E-CRISPR-associated-protein-Cse2/CasB
MSEESYVRMYFVTKQILIKLNKQQNTSAGKAMLARLRHSVGKPISEAKEVWPILFENVPENFLSQYDNASYEEIAILTAIQLYALYQQGMSHNVFDDSAKKFQNIGYSLKSIRTRVDTVAVDRRFNTMITATTFEELVHHLRQLITLLKSKTPETKIDFARLATDLYCFLRDYQETVRLKWARQYYKHSSEEEAENDN
>CP033199.1|AYO47355.1|357391_359074_+|type-I-E-CRISPR-associated-protein-Cse1/CasA
MSRFNLLDEPWISVVFDEKGSTKEVSLLDFFQNAHHYKDLAGDTKTQDFAVLRVLLAVLHTVFSRFDANGNVYGYLEIDEKYRQIEEIEEDDLEEYEDDLYETWLTLWQNRQFPDIIEEYLKKWRDRFYLFDEEYPFFQVRREDISEDKINQKSATSIFGRNVNKTISESNNKITLFSPRDNRNKDILSASEVARWLLTFQGYTGVFDKTTFKGGKGSPSKGWIYDLGGVFVKGSNLFTTLLLNFILPYQERDNLINIQSPSWEFDSNELISMYLAGKEINNIAGLYTVWSRGIYIDSNPDLSLPFSFEIVKLPDINHQDNFLEPMTLCIYNQLGNNKGHYTPKKHVSNQSLWRSFGLLVNGQNNQRRPGIIDWLEVECIRDVIGIIPITICSVSMKDDGNTSSRMPTDEIIDTFSINEFVLTDFQENGWTTRINNIVEETKTVISVIYKDYVDDIRKIRNIKSGTFITQKLEELYFKIDQPFRQWLSGIHYGDEKDEKVFKWRGVLKKLVHQEAKILLQDGGPRDYIGIVDKDNETVKNIVTAYESFNYRLNKNLKEKK
>CP033199.1|AYO47354.1|354612_357399_+|CRISPR-associated-helicase/endonuclease-Cas3
MDKKVLRYNFWAKKREEKGQFLWLPLMQHLEDTKNVAGLLWEHWLGEGQRALIIASLKTGKKDEKTAKQLAQFLAAVHDIGKATPVFQSKKGYANSKDLDLELLEKLERAGFEGISSITLANPEKSPHALAGQYILHYNKVKEDIATIVGGHHGKPVDDRATYKNQRSQESNYYQSGKSGNTIYQKWERAQEEILNWALEVSGFKSVDELPTIKQSAQVILSGLLIMADWIASNEDYFPLISIDEREVENKADRLSGFEKWKRSSLWVSRNTWDFEGLYQARFDFEPRDVQAVLSKTIADTEQPGIFILEAPMGIGKTEAALVATEQLAEKTDRNGIFFGLPTQATSNGIFPRIEKWLESIKEDLDDNISIQLVHGKAALNADFSELPKGISINIDDFENGSVIVNEWFSGRKTAVLDDFVVGTVDQFLMLALKQKHLALRHLGFSKKVVVIDEVHAYDAYMNQYLLEALRWMGAYGVPVIILSATLPAERREKLLKSYMFGMGKRFEEKEKEQLSKQLKTEAYPLITYNNGFDICQITEFKKGENKKILLSQLEEEDLLDTVKGLLSDGGVAGIIVNTVKRAQKIAKVFADSLGEDMVEIFHSGFIATERVRKEQELLKMIGKDANRPYRKIIIGTQVIEQSLDIDFDVMISDLAPMDLLIQRMGRLHRHKIDRPQKHVFPKFYVIGMNVDLKFEEGSSFVYGDYLLARTQYYLPDSINLPEDISILVQKVYDEKLELDYPTELLDKKYHNAKSEHETKIGNKESKARDYRIADPVLRETRSRKENLIGWLENSHPDDSDERAYAQVRDIEDIVEVIALKKVGDGYALFGEGEDLSELITDFNIAKKVAQNTLRLPIALTKSYNVDDTIKELEMYSRMNLNNWQDSSWLKGALGIIFDENNEFLIGGYKLVYDEKYGVRMEEIENHE
>CP033199.1|AYO47353.1|353439_354423_+|WYL-domain-containing-protein
MDEFNQVERFLYLYTELYKGNTISKQVYLDKFGVSDASFNKDIRKLKDAARHLNLDFDIKINKKESYYYLDYTSETGGNLSDIEAYTLSKILLESRALSKKKTKNIIKKLINRTVNEDYRTILDKQTENELSFYKQLNYFNDENHDQNYLSNLGKLSQAVEDTLKTEIPIKIEYSSKGETKSALILPFAILFHEYYFYITSYKFENEEWVSRTYRLDRIESISNADGKEIVKAQAFFHKYPSPSLIHDQVIMMFSGEPYLIRLKIVDKTITEYLKDALPTLQVIDEEEAIYEIRTLGVEGIQLFLRRYGSQVEFVSMTELNTGDNEG
>CP033199.1|AYO47352.1|352529_352775_+|hypothetical-protein
MLILGWVATFMSIMMYVSYIPQIMNNLAGNKGDFIQPSVAALNCTLWVIYGLCKEKRDLPLAAANMPGIVFGLIAAITALV
>CP033199.1|AYO47351.1|352028_352355_+|hypothetical-protein
MTHVVSEIFKDGPVDRFGLRGDPVFWNYLEKHFQKVAMPYSERKLEEDIRTIYQDLTGKEFRMGEMALVKDFISESGGMSSGWLSDDFWLKSAIPLLKKRLAKWNETL
>CP033199.1|AYO47360.1|366214_369457_+|ATP-dependent-nuclease-subunit-B
MKLLYTDIPYNITEILAEEAQIAAKAGKRVFYIAPNSLSFEKERAVLETLPERASFAITITRFEQMARYFVLNDIHQGETIDDNGLVMVFYRVLSSFSDQDLRVFGRLKQDAHFINQLVDLYKELKASNLTVLELNQLNSAEKQEDLIKIFTEVETILSAGHFDNQSKIAFFAQQIKFGHLDTALQDLTIVIDGFTRFSAEEENLIGLLHEKGVDIIIGTYISQKAYRSTFSNGNVYQASLDFIRGLAGKFQTKPEYVVSKQEALPAFTKLSQLFESRHDFSDSQLVLTDKDKEHVTIWDVINQKEEVEHVAKSIRRKLYEGHRYKDILVLLGDVDAYKLQIGKIFDKYEIPYYFGKAESMSSHPLVHFVDSLERVKRYNFRAEDVMNLLKSGLYGKIRQNQLDKLEQYVIYADIKGKTKFFKDFTLDNHGQFDLKALNKLRAEVMSPLQELVKIQTQKGDSILQKLTNFLEAISLTNNFSKLIQGVNDIEQEKNEQVWKTFTVILEQFHTIFGQEKMKLADFLALLRSGMLAADYRTVPASVDVVTVKSYDLVEPHSNKFVFALGMTQSHFPKIVQNKSLISDEERAKINEATPDNRRFDIVTKENLKKNHFTALSLFNAATQELVLTLPQILNEAEDNTSSYLLELQDMGVPVVEKGRNRLAADPEDIGNYKALLSRVIELNRSAIDQELSKEEQTFWSVAVRYLRQKLAKEGLTIPEVNDKMQTKQVAAEVMAARFPIDQPLNLSSSALTTFYNNQYLYFLQYILGLQDLETIHPDARNHGTYLHRVFELVMQDQSTDDFDSKLNRAIDITNHEDSFHLVYNEDEESRYALGILEDIARSTATVLKGDNPVQAESEEEAFELMLDQAVKIRGVIDRIDRLSDGSLGIVDYKSSKNTFDLQKFYNGLSPQLVTYIEALRSCKNLNDTDKIFGAMYLHMQEPKTDLANMKSIEKIPETVHKNLSYKGLFLEDEKAHLANGKYHLHDAVYSQKEVDLLLDYNKRLYRSAAKQIRKGNFLINPYSQDGKSVQGEQLKAITHFEADRHMPYARKLYQLPRKEKRQGFLALMQSKKEEEGNDL
>CP033199.1|AYO47361.1|369446_373085_+|helicase-exonuclease-AddAB-subunit-AddA
MTFKPFLTDQEIASLQIQEAQSDKKQKRTPEQIEAIYTSGTNILVSASAGSGKTFVMIERIMDKILRGVTIDQLFISTFTVKAAGELKERLEKKITEQLRLTNDTALKQFLSEQLLGLQTADIGTMDAFTQKLVTQYGYTLGISPNFRILQDKSEQDLLKNDVFDDLFTDYRTGDQAELFTKLVRNFAGNRKDSSNFRQIIYKIYDFSQATDNPQRWLLENFLKGANTYKDFSAIPEQEVKDFLNTLQETALALRDVTDLEDYKQVTAKGTPTAAYQRHLKMIEQLQDWVLHFDSLYGRDGLGKLANDIATLIPSGNDVTVAGVKYPVFRSLHSRLRGLKHLETIFKYQDQSLPLLQVLQSFTLDFSKQYLQAKMQENAFEFSDIAHFAIQILEENDAIRQLYIDKYHEVMVDEYQDNNHTQERMLELLSNGRNRFMVGDIKQSIYRFRQADPQIFNQKFKDFQEHPEHGKLILLKENFRSQSEVLDATNSVFTHLMDETVGEILYDDTHQLVAGSSAQKIPYPQNETQVLIYDTKDQQNQDLAVEDDSNQISLGEVKLVAKEIIRLHNEEKVQFEDITLLVSSRTRNDGILQTFDDYGIPLVTDGGEQNYLKSVEVMVMLDTLRSIDNPLNDYALVALLRSPMFAFDEDDLARLALQNLPDQHKQNLYEKMENARNGQGQQVQLITEALSAKLDAFFETFLSWREFSLLNSLYDLIWKIYNDKFYYDYVGSLPKSEQRQANLYALALRADNFEKTGFKGLSRFIRMIDKILENQNDLADVEVALPKNAVTLMTIHKSKGLEFKYVFILNIDKKFSIQDMTSPLILSRQNGVGIKYIADMKEELEEKLLPTVKVSMDTLPYQLNKRELRLATLSEQMRLLYVAMTRSEKKLYLVGKGSQEKLGDKYDGKSENNHLPVADREHYLTFQDWLLAIEAAYAADELHFKTSFITDEDLTEDKMGSLEAEQAYDADNLKDNRQSDDIARALDMLEAVEKLNQHYKAAIHLPTVRTPSQIKKFYEPVMETEGVEVMQTSYQTKPKFELPQFSKKANQDPTALGSSVHELMQRLHLSEQVSLEDILTALAELSVEENVKKAIQVDKILHFFQTSQLGKLIQANADKVYREAPFAMLQADPASGEDYVVRGIIDGYILFDNRIVLFDYKTDKFTNSQAIKERYRGQMTLYAQALSQSYNIQQVDSYLILLGGEKLEVVEI
>CP033199.1|AYO47362.1|373309_374065_+|DeoR-family-transcriptional-regulator
MKKEERLEEITKLINKRGTIRVTEVVERLKVSDMTVRRDLTELEGLGVLTRIHGGARSNNIFQYKEMSHEEKHSRQIEEKHYIAQKAAELVEEGDTIFLGPGTTVELLAEEINKTTLQVITNCLPVFQILSQKQSETFRVHLLGGEMRSITQSFIGEITNIVLEKMHFSKMFFSGNGVKGNEVMTSSFQEAYTQKMALGRAIEKYLLIDSSKIGKEDFTSFYQLSQLTALITDCQDDDKLQKLSKYTEIIN
>CP033199.1|AYO47363.1|374371_374800_+|galactose-6-phosphate-isomerase-subunit-LacA
MAIIIGSDAAGKRLKDVIKTFLKDNNHEVLDVTERKDLDFVDSTLAVVHEVQKNDKNLGIAIDAYGAGSFMVATKVKGMIAAEVSDERSAYMTRGHNNARIITLGAEIVGDELAKNIVKDFVEAKYDGGRHQIRVDMLNKMC
>CP033199.1|AYO47364.1|374825_375341_+|galactose-6-phosphate-isomerase-subunit-LacB
MKIAIGCDHIVTDVKMELSKHLKEEGYEVLDVGTYDFTRTHYPIFGKKVGEAVSSGEADLGVCMCGTGVGISNAANKVPGVRTALVRDMTSALYSKEELNANVVSFGGAIIGKLLLFDIVDAFIKAQYKPTEENKKLIAKIKHLEAHNDKQADPHFFDEFLEKWNRGDYHD
>CP033199.1|AYO47365.1|375359_376292_+|tagatose-6-phosphate-kinase
MMLTVTMNPSIDIAYQLDDLKVDTVNRVIETHKTPGGKGLNVTRVLSQLGDDVLASGLLGGKLGEFLEAELDKSAIKHSFYKISAETRNCIAILHGGYQTEILEQGPYVSAKESKGFLEFFEKLLPKLEVVAISGSLPKGVPVDYYSQMIAICKQHQVPIVLDCSGQALLEVLNGAAKPTVIKPNTEELSQIMEREITNDVAVLKYALASPIFSGIDWIIVSLGSQGSFAKHGQTFYKVTIPKIAVVNPVGSGDSTVAGITSALAAGASDEKLLKKANTLGMLNAQEKLTGHVNLENYDNLYQQIEVAEV
>CP033199.1|AYO47366.1|376296_377274_+|tagatose-1,6-diphosphate-aldolase
MTLTQEKRSYMEKLSDENGIISALAFDQRGALKRLMAQYQTQEPTIAQMEELKVLVAEELTPYASSMLLDPEYGLPAAKHLDKNAGLLLAYEKTGYDTTSTKRLPDCLVEWSAKRLKKQGADAVKFLLYYDVDGDEEVNQQKQAYIERIGSECKAEDIPFFLEILAYDETITDAASVEYAKVKPHKVLDAMKVFSDERFGIDVLKVEVPVNMKYVEGFGDGPIVHTQDQAANFFKQQDQATPLPYIYLSAGVSAKLFQDTLVFAKESGANFNGVLCGRATWAGSVKDYIEKGEAAARQWLRTEGFKNIDELNKVLKATATSWKER
>CP033199.1|AYO47367.1|377289_377604_+|lactose-specific-phosphotransferase-enzyme-IIA-component
MNREEATLLGFEIVAYAGDARSKLLEALNAAQAGEYDRAEELVAAADDCIVDAHKAQTSLLAKEAQGDDIELSVTLMHGQDHLMTTILLKDLMKHLIELYKRGS
>CP033199.1|AYO47368.1|377610_379317_+|PTS-lactose-transporter-subunit-IIBC
MNTLIAQIEKGKPFFEKISRNIYLRAIRDGFISAMPVILFSSIFLLIAYVPNIFGFTWPKGIENMLMTPYNYTMGIIGFLVAGTTAKSLTDSMNRQLEKTNQINFISTMLASMAGFLIMAADPAKEGGFLSAFMGTKGLLTAFIAAFITVNVYKICVKNNVTIRMPEEVPPNISQVFKDIFPFAFSIIILYAIQLAIKAVIGVNVAQSIGTLLAPLFSAADGYLGITIIFGAYALFWFVGIHGPSIVEPAIAAITYSNVELNAHLIHAGQHADKVITSGTQMFIVTMGGTGATLVVPFMFMWLCKSKRNKAIGRASVVPTFFGVNEPILFGAPIVLNPVFFIPFILAPIVNVWIFKFFVDTLGMNSFFANLPWTTPGPLGIVLGTGFAVLSFVLAALLILVDTVIYYPFVKVYDEQILAEEAEGKSSSDALKEKVAANFDTKKADAILEGAESKEEPATHAITEETNVLVLCAGGGTSGLLANALNKAAEEYGAPVKAAAGSYGAHREILDQYQLVILAPQVASNYEDMKAETDKLGIKLAKTEGAQYIGLTRDGKGALAFVEEQFKD
>CP033199.1|AYO47369.1|379328_380735_+|6-phospho-beta-galactosidase
MSKTLPKDFIFGGATAAYQAEGATHADGKGPVAWDKYLEDNYWYTAEPASDFYHQYPVDLKLAEEFGVNGIRISIAWSRIFPKGYGAVNPKGLAFYHNLFAECHKRHVEPFVTLHHFDTPEALHSNGDFLNRENIEHFVNYAEFCFKEFPEVNYWTTFNEIGPIGDGQYLVGKFPPGIQYDLAKVFQSHHNMMVAHSKAVKLFKDGGYSGEIGVVHALPTKYPYDPNNPADIRAAELEDIIHNKFILDATYLGKYSEKTMEGVNHILAVNGGQLDLREEDFAALEAAKDLNDFLGINYYMSDWMRAFDGETEITHNAKGEKGSSKYQIKGVGRREAPVNVPKTDWDWIIYPQGLYDQIMRVKQDYPNYKKIYITENGLGYKDEFVNHTVYDDARIDYVKKHLEVLSDAIADGANVKGYFIWSLMDVFSWSNGYEKRYGLFYVDFDTQERYPKKSAYWYKKLAETQIID

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Crispr_ID: CP033199_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP033199_2

465262-466089

TypeII

II-A,II-B

Consensus_repeat	Method
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	PILER-CR
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	CRISPRCasFinder
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	CRT

12 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of CP033199_2

>merge|CP033199|2|465262-466089|PILER-CR,CRISPRCasFinder,CRT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACAGAGCCGGAAACAGCAGAAGGACAGGCTCAGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACAACTTCTTCAGCTGTCAGCCTTTTAGCGTTGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACCCCATCAGGTTTTGAGCCAATAAACTTATAGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACTGCCAGTTACACTCCCTTTAACGAGTCCTGGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACTACACTGGCACAGTAGCTAAGTTTCAGCACGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACCTAACTCTCCAAAAGATATCATCTGTCAGTGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACTAGACAGCGATTCTATCGCGCTAGAATGCGGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACTAATGATATATATGGTTCAGCATTCTTTAAGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACTCTTTCTGTTACATGCTCCAGAAAGTCAATGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACTAAAACAACTGAAAAAGGGACGTTTGTCGAGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACTATAGCGCTTATTGACAGCGAAGCGACAAAGTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAACAATAGAATCAAATTCTCCTAAGTCAGTTAAGTTTTAGAGCCATGTTAGTTACTGATTTACTAAAAC

>CP033199|2|2|465262-466023|PILER-CR
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	AGAGCCGGAAACAGCAGAAGGACAGGCTCA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	AACTTCTTCAGCTGTCAGCCTTTTAGCGTT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	CCCATCAGGTTTTGAGCCAATAAACTTATA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TGCCAGTTACACTCCCTTTAACGAGTCCTG
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TACACTGGCACAGTAGCTAAGTTTCAGCAC
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	CTAACTCTCCAAAAGATATCATCTGTCAGT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TAGACAGCGATTCTATCGCGCTAGAATGCG
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TAATGATATATATGGTTCAGCATTCTTTAA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TCTTTCTGTTACATGCTCCAGAAAGTCAAT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TAAAACAACTGAAAAAGGGACGTTTGTCGA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TATAGCGCTTATTGACAGCGAAGCGACAAA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC

>CP033199|2|2|465262-466023|CRISPRCasFinder
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	AGAGCCGGAAACAGCAGAAGGACAGGCTCA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	AACTTCTTCAGCTGTCAGCCTTTTAGCGTT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	CCCATCAGGTTTTGAGCCAATAAACTTATA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TGCCAGTTACACTCCCTTTAACGAGTCCTG
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TACACTGGCACAGTAGCTAAGTTTCAGCAC
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	CTAACTCTCCAAAAGATATCATCTGTCAGT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TAGACAGCGATTCTATCGCGCTAGAATGCG
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TAATGATATATATGGTTCAGCATTCTTTAA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TCTTTCTGTTACATGCTCCAGAAAGTCAAT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TAAAACAACTGAAAAAGGGACGTTTGTCGA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TATAGCGCTTATTGACAGCGAAGCGACAAA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC

>CP033199|2|2|465262-466089|CRT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	AGAGCCGGAAACAGCAGAAGGACAGGCTCA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	AACTTCTTCAGCTGTCAGCCTTTTAGCGTT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	CCCATCAGGTTTTGAGCCAATAAACTTATA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TGCCAGTTACACTCCCTTTAACGAGTCCTG
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TACACTGGCACAGTAGCTAAGTTTCAGCAC
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	CTAACTCTCCAAAAGATATCATCTGTCAGT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TAGACAGCGATTCTATCGCGCTAGAATGCG
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TAATGATATATATGGTTCAGCATTCTTTAA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TCTTTCTGTTACATGCTCCAGAAAGTCAAT
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TAAAACAACTGAAAAAGGGACGTTTGTCGA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	TATAGCGCTTATTGACAGCGAAGCGACAAA
GTTTTAGAGCTGTGTTGTTTCGAATGGTTCCAAAAC	AATAGAATCAAATTCTCCTAAGTCAGTTAA
GTTTTAGAGCCATGTTAGTTACTGATTTACTAAAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP033199.1\|AYO47433.1\|453493_454669_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|341026
CP033199.1\|AYO47437.1\|462565_463432_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
CP033199.1\|AYO47439.1\|463762_464425_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd09758_csn2_CAS-II-A	gnl\|CDD\|213408
CP033199.1\|AYO47449.1\|474339_474996_-\|hypothetical-protein	unknown	unknown	unknown
CP033199.1\|AYO47448.1\|473666_474275_+\|hypothetical-protein	unknown	unknown	unknown
CP033199.1\|AYO47438.1\|463443_463773_+\|CRISPR-associated-endonuclease-Cas2	cas2	COG3512_cas2_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226043
CP033199.1\|AYO47434.1\|456295_457174_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
CP033199.1\|AYO47442.1\|467827_469579_+\|LPXTG-cell-wall-anchor-domain-containing-protein	unknown	unknown	gnl\|CDD\|369832
CP033199.1\|AYO47447.1\|473110_473587_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP033199.1\|AYO47446.1\|472202_473030_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
CP033199.1\|AYO47443.1\|469708_469939_+\|hypothetical-protein	unknown	unknown	unknown
CP033199.1\|AYO47436.1\|458528_462566_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	COG3513_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|226044
CP033199.1\|AYO47435.1\|457281_458148_+\|NADPH-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|377026
CP033199.1\|AYO48824.1\|464730_465108_+\|HicB-family-protein	unknown	unknown	gnl\|CDD\|374224
CP033199.1\|AYO47441.1\|467380_467665_+\|XRE-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197775
CP033199.1\|AYO48825.1\|466171_467026_-\|LexA-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|119397
CP033199.1\|AYO47440.1\|464521_464713_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	unknown	unknown	gnl\|CDD\|377942
CP033199.1\|AYO47432.1\|450789_453318_+\|ATP-binding-cassette-domain-containing-protein	unknown	unknown	gnl\|CDD\|213222
CP033199.1\|AYO47445.1\|470338_472174_+\|elongation-factor-4	unknown	unknown	gnl\|CDD\|235462
CP033199.1\|AYO47444.1\|469973_470102_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP033199.1\|AYO47433.1\|453493_454669_-\|MFS-transporter	gnl\|CDD\|341026	cd17473, MFS_arabinose_efflux_permease_like, Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily. This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.88895e-50
CP033199.1\|AYO47437.1\|462565_463432_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	1.37497e-128
CP033199.1\|AYO47439.1\|463762_464425_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213408	cd09758, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	2.87674e-116
CP033199.1\|AYO47438.1\|463443_463773_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	4.33925e-49
CP033199.1\|AYO47434.1\|456295_457174_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	7.84875e-21
CP033199.1\|AYO47442.1\|467827_469579_+\|LPXTG-cell-wall-anchor-domain-containing-protein	gnl\|CDD\|369832	pfam08363, GbpC, Glucan-binding protein C. This domain is found in the Streptococcus Glucan-binding protein C (GbpC) and also in surface protein antigen (Spa)-family proteins which show sequence similarity to GbpC.	7.91627e-110
CP033199.1\|AYO47447.1\|473110_473587_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.55706e-16
CP033199.1\|AYO47446.1\|472202_473030_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	2.26726e-06
CP033199.1\|AYO47436.1\|458528_462566_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|226044	COG3513, COG3513, Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms].	0
CP033199.1\|AYO47435.1\|457281_458148_+\|NADPH-dependent-oxidoreductase	gnl\|CDD\|377026	pfam03358, FMN_red, NADPH-dependent FMN reductase.	2.74106e-38
CP033199.1\|AYO48824.1\|464730_465108_+\|HicB-family-protein	gnl\|CDD\|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	2.66065e-14
CP033199.1\|AYO47441.1\|467380_467665_+\|XRE-family-transcriptional-regulator	gnl\|CDD\|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	8.64754e-07
CP033199.1\|AYO48825.1\|466171_467026_-\|LexA-family-transcriptional-regulator	gnl\|CDD\|119397	cd06529, S24_LexA-like, Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the repressor of genes in the cellular SOS response to DNA damage; MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage; RulA, a component of the rulAB locus that confers resistance to UV, and RuvA, which is a component of the RuvABC resolvasome that catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. The LexA-like proteins contain two-domains: an N-terminal DNA binding domain and a C-terminal domain (CTD) that provides LexA dimerization as well as cleavage activity. They undergo autolysis, cleaving at an Ala-Gly or a Cys-Gly bond, separating the DNA-binding domain from the rest of the protein. In the presence of single-stranded DNA, the LexA, UmuD and MucA proteins interact with RecA, activating self cleavage, thus either derepressing transcription in the case of LexA or activating the lesion-bypass polymerase in the case of UmuD and MucA. The LexA proteins are serine proteases that carry out catalysis using a serine/lysine dyad instead of the prototypical serine/histidine/aspartic acid triad found in most serine proteases. LexA sequence homologs are found in almost all of the bacterial genomes sequenced to date, covering a large number of phyla, suggesting both, an ancient origin and a widespread distribution of lexA and the SOS response.	2.91013e-23
CP033199.1\|AYO47440.1\|464521_464713_+\|type-II-toxin-antitoxin-system-HicA-family-toxin	gnl\|CDD\|377942	pfam07927, HicA_toxin, HicA toxin of bacterial toxin-antitoxin,. HicA_toxin is a bacterial family of toxins that act as mRNA interferases. The antitoxin that neutralizes this is family HicB, pfam15919.	3.38968e-15
CP033199.1\|AYO47432.1\|450789_453318_+\|ATP-binding-cassette-domain-containing-protein	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	6.35968e-103
CP033199.1\|AYO47445.1\|470338_472174_+\|elongation-factor-4	gnl\|CDD\|235462	PRK05433, PRK05433, GTP-binding protein LepA; Provisional.	0

>CP033199.1|AYO48824.1|464730_465108_+|HicB-family-protein
MLKSYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADPNPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALEKKLQL
>CP033199.1|AYO47440.1|464521_464713_+|type-II-toxin-antitoxin-system-HicA-family-toxin
MPLTGKELARLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL
>CP033199.1|AYO47439.1|463762_464425_+|type-II-A-CRISPR-associated-protein-Csn2
MKLNFPILDEPITLEKSTILVLEDVQVFAQMVRNLYQYDEDSELKFFNRKFKSLKPSELMLVTDILGYDVNAPSLLKLVHADLENQFNEKPEVKSMVEKLANTITELIAYECLENELDLEYDEITILELIKALGVKIETQSDTIFEKMFEVLQVYKYLNKKKLLVFINTLSYFKREEIAQILEYIHLSDMVVLFIEPRKIDGFAQYILDEDYFLITESNN
>CP033199.1|AYO47438.1|463443_463773_+|CRISPR-associated-endonuclease-Cas2
MRMILMFDMPTDTAEERKAYRKFRKFLLSEGFIMHQFSVYSKLLLNNSANTAMIARLKENNPKKGNITLLTVTEKQFARMIYLNGERDTSIANSDSRLVFLGEAFPDET
>CP033199.1|AYO47437.1|462565_463432_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRTVVVNTHSKLSYKNNHLIFKDTYQTEMIHLSEIDILLLETTDIVLSTMLVKRLVDENILLIFCDDKRLPTAMLMPYYARHDSSLQLNNQISWAEEVKCDVWTTIIAQKILNQSCYLGECFYFEKSQSIMDLYHDLEPFDPSNREGHSARIYFNTLFGNDFSREQDNDINAGLDYGYTLLLSMFAREVVVSGCMTQFGLKHANQFNQFNFASDIMEPFRPIVDRIVYENRNNSFIKIKRELFSMFSDTYLYNNKEMYLTNIVSDYTKKVIKALNNDGKGVPEFRI
>CP033199.1|AYO47436.1|458528_462566_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MKKPYSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTAEDRRLKRTARRRYTRRRNRILYLQEIFSEEMGKVDDSFFHRLEDSFLVTEDKRGERHPIFGNLEEEVKYHENFPTIYHLRQYLADNPEKVDLRLVYLALAHIIKFRGHFLIEGKFDTRNNDVQRLFQEFLAVYDNTFENSSLQEQNVQVEEILTDKISKSAKKDRVLKLFPNEKSNGRFAEFLKLIVGNQADFKKHFELEEKAPLQFSKDTYEEELEVLLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKQFIRQKLSDKYNEVFSDVSKDGYAGYIDGKTNQEAFYKYLKGLLNKIEGSGYFLDKIEREDFLRKQRTFDNGSIPHQIHLQEMRAIIRRQAEFYPFLADNQDRIEKLLTFRIPYYVGPLARGKSDFAWLSRKSADKITPWNFDEIVDKESSAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKTEQGKTAFFDANMKQEIFDGVFKVYRKVTKDKLMDFLEKEFDEFRIVDLTGLDKENKAFNASYGTYHDLRKILDKDFLDNSKNEKILEDIVLTLTLFEDREMIRKRLKNYSDLLTKEQLKKLERRHYTGWGRLSAELIHGIRNKESRKTILDYLIDDGNSNRNFMQLINDDALSFKEEIAKAQVIGETDNLNQVVSDIAGSPAIKKGILQSLKIVDELVKIMGHQPENIVVEMARENQFTNQGRRNSQQRLKGLTDSIKEFGSQILKEHPVENSQLQNDRLFLYYLQNGRDMYTGEELDIDYLSQYDIDHIIPQAFIKDNSIDNRVLTSSKENRGKSDDVPSKDVVRKMKSYWSKLLSAKLITQRKFDNLTKGERGGLTDDDKAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIRQVKIVTLKSNLVSNFRKEFELYKVREINDYHHAHDAYLNAVIGKALLGVYPQLEPEFVYGDYPHFHGHKENKATAKKFFYSNIMNFFKKDDVRTDKNGEIIWKKDEYISNIKKVLSYPQVNIVKKVEEQTGGFSKESILPKGDSDKLIPRKTKKFYWDTKKYGGFDSPIVAYSILVIADIEKGKSKKLKTVKALVGVTIMEKMTFERDPVAFLERKGYRNVQEENIIKLPKYSLFKLENGRKRLLASARELQKGNEIVLPNHLGTLLYHAKNIHKVDEPKHLDYVDKHKDEFKELLDVVSNFSKKYTLAEGNLEKIKELYAQNNGEDLKELASSFINLLTFTAIGAPATFKFFDKNIDRKRYTSTTEILNATLIHQSITGLYETRIDLSKLGGD
>CP033199.1|AYO47435.1|457281_458148_+|NADPH-dependent-oxidoreductase
MKLVAIVGSNASFSYNRLLLQFIKERFGQAFALEILEIKELPLFNQDSSAADCPLIQKLNEDILNADGIIIATAEHNQTITASLKSMLEWLSYQLHPFKNKPVMIVGASYYNQGTSHAQEHLRQILNAPGLDAWVMPGNEFFLGNASEVFDENNQIKDDDTVIYLAQCLQRFIRYVTVVQELKGDSIQLSDAISGASESVQEDSAASAMLEKRLSLQKKETNTPFERALDKTYGPALKDTLEDPFDKDLDAQYKAIKKQPIPFEKALDNIFGKDLGIETTDPLDNLLR
>CP033199.1|AYO47434.1|456295_457174_+|AraC-family-transcriptional-regulator
MVRFISNTLSQTLNEPFQQSHKSCKHLYILEILSQVVIVSDQKQVPLQPYDIILAQSFNHLQIDSLDRNPILLRLYSLDFDLPSPLNQYTVGDNPLIHDLMNDHTSEDAYILFTNLSDLICHAYLDALEKLENLRDNNDEQVYIDFQRQKLAGLLFTELLRQHDAKVSKFASRFPSVNVKYASKDSQSGAIMKYVSDNVHHISLKEAAAHFSYQANYFSRLCHDLFGISFNQLKTTIRLEIAKEQLRLTTKSVEEISQELGYKAVSNFHRNFKSQTGMTPNDYRQDKQWKDT
>CP033199.1|AYO47433.1|453493_454669_-|MFS-transporter
MNQKNLSPSSWLFKISVLSLSILAMTAPSISIANNLLQKTFTQQSTAEIEMISTLPNFGVLLLILFADTIANKFGIKRTITAGLLMYLLGGVLPSFIPNYYAIVFLRFLMGCGIGLFNPFSVSLMYRFYKDQELSDMLGFQNTGQNLGNAGFGFLLGALVLAGWKVAFMGYFIALIPLILFGAFVVIPDDQPTIKKERPKLADSINGHILLLALLFLIIFGMFMMMTIKMALFGAETGLISASAASSILAVLGLSSMFSAIAFGKLSKRVGNFMLPISLTGIAMGFFIVASASNAAMVVFGVIIAGIFFGWVFPQAFLRAAQVGPKEGGTLTTSVILMGINLGAFLSPSIVNFVANLLGNKTAASVLAMCGWGFALLAILEYLYTFFNQRT
>CP033199.1|AYO47432.1|450789_453318_+|ATP-binding-cassette-domain-containing-protein
MLELKHITKVYETAGIKRMALENVSVNFRANEFVAVLGQSGSGKTTLLNIIGGLDQYTTGDLLINGKSTKDFKDKDWDSYRNNTIGFVFQSYNLISHQTALANVELALTLSGVSKAERRKRALDALKRVGLEDEINKKPNQMSGGQMQRVAIARALVNNPDILLADEPTGALDSETSLQIMDLLKEIAQERLVIMVTHNPDLAEKYSNRIIKVLDGHIINDSNPYTDDEIRKATVDFKKTKMSFTTALSLSFNNLLTKKGRTLLTAFAGSIGIIGIALILSLSNGVQKYIAKTQEDTLVAYPLSIEKSSNKNFIGLLAANSNENKKSDKKKTNKKIGTNSILKNMISTQVVDNDLASFKTYIKKHQKKFAAVTKDIQYSYKITPRIYQSDTSKGVKAVNPNTLSKDLKDTSTSIQTVVSNLDIWQELSSNEKMLSSQYQVISGHLPKQYNEVVLMADENNKIDDYVLYSLGIKDAKQLNSKTIKKVKASSYHYKDLIGRTYKLVINSDLYQKEGNAWIDRSDNDAYMKQVINAAENIKIVGIVKPQEGTTSESSSAGVGYSHDLTDYLAKKIKSSTIAKEQLANKKLNVFTGQSFSSGNKTFSSDNLSVQQQASMASMSAEELADYVNRYNENANATYKDNLEKIGIIDNNNPETIHFYASSFKDKEALKDLISDYNKKVKKDKHKSRVIRYTDTVGLMMSSVTTMINAVTYILIGFVAISLIVSSIMIGIITYISVLERTKEIGVLRAMGASKRDVTRIFTAETIIEGAIAGVLGILITLLLNIAITLIVKNWLNINHISSLPIWSAIVLIAISIVLTVFAGILPSRVAAKKDPVEALRTE
>CP033199.1|AYO48825.1|466171_467026_-|LexA-family-transcriptional-regulator
MKAISANLQRLLAESGMKQSHLATILNIPTSSLNEYVKGKSLPKIGNIQKIADYFGLQKSDIDPRFASKKDSSTLDKINHIAKQLEMKRQIKVLDFCYQQSKEQDETASLSASDETTDDKVADKSNHTQYQKVVDSFIAKELNDQTIIHWDNVIKAKDLYQTFGRQYENIQIYGEVSAGTGIWVGHEKQETIKYPIPIPEHDIALTVNGNSMEPLFYNGDVIFVKKTKAIHHGQIIVIIVNNEAYVKKLYRKNKEIRLISLNPDYDDIILKEDDTIEVIGTVIT
>CP033199.1|AYO47441.1|467380_467665_+|XRE-family-transcriptional-regulator
MQFVWESNGKLKGDAEVEKLTLRALRVNYSLSPKEVADCLGIPQHTLLSYEEDSSEIPIQLANDLANYYDISLDSIFFGKNSDLKQKFKNKNNR
>CP033199.1|AYO47442.1|467827_469579_+|LPXTG-cell-wall-anchor-domain-containing-protein
MKSKTAKITLLSSLALAAFGATNVFADEASTQLNSDTVAAPTADTQASEPAATEKEQSPVVTVVESHTQGNTTTTTSQVTSKELEDAKANANQEGLEVTETETQKQPSVEAADADNKAQAQTINTAVADYQKAKAEFPQKQEQYNKDFEKYQSDVKEYEAQKAAYEQYKKEVAQGLASGRVEKAQGLVFINEPEAKLSIEGVNQYLTKEARQKHATEDILQQYNTDNYTASDFTQANPYDPKEDTWFKMKVGDQISVTYDNIVNSKYNDKKISKVKINYTLNSSTNNEGSALVNLFHDPTKTIFIGAQTSNAGRNDKISVTMQIIFYDENGNEIDLSGNNAIMSLSSLNHWTTKYGDHVEKVNLGDNEFVKIPGSSVDLHGNEIYSAKDNQYKANGATFNGDGADGWDAVNADGTPRAATAYYGAGAMTYKGEPFTFTVGGNDQNLPTTIWFATNSAVAVPKDPGAKPTPPEKPELKKPTVTWHKNLVVETKTEEVPPVTPPTTPDEPTPEKPKTPEDPQSPVVAKSVSFRTARKGEMRVRERDYQPTLPHTGAAKQNGLATFGAISTAFAAATLIAARKKEN
>CP033199.1|AYO47443.1|469708_469939_+|hypothetical-protein
MLIPSQFCGGGTAELKSQFHYDLSIFIPFFVVFVMGKFTISIMELLSSPKRSYDFIVRLNGLSLFDMQNIGIFNNN
>CP033199.1|AYO47444.1|469973_470102_+|hypothetical-protein
MTDQELEHLIVTELESKRLDFTYSKDITEFFDEAFPEYDQNY
>CP033199.1|AYO47445.1|470338_472174_+|elongation-factor-4
MTIEQLKNRQEKIRNFSIIAHIDHGKSTLADRILEQTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYKAKNGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRTEIEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPKGDVEAPLKALIFDSVYDAYRGVILQIRVMDGMVKPGDKIELMSNGKTFDVTEVGIFTPKAVNRDFLATGDVGYLAASIKTVADTRVGDTVTLADCPAEAPLHGYKQLNPMVFAGIYPIDSSKYNDMREALEKLQLNDASLHFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVYTTDGERLEVSNPSEFPDPTKVDSIEEPYVKAQIMVPQEYVGAVMELSQRKRGDFVTMDYIDNNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYDISEYRKSKLVKMDILLNGDKVDALSFIVHKEFAYERGKLIVEKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKSIGSVEVPQEAFLSVLSMDDDDKKK
>CP033199.1|AYO47446.1|472202_473030_+|alpha/beta-hydrolase
MAALNKEIVNTLLGPIYTCHREGNPCFVFLSGAGFFSTADNFANIIDKLPDSIGILTIDAPNSGYSPVSNQANVGLRDWVNAILMIFEHFKFQSYLLCVHSIGGFTALQIMNQSSKACLGFIGLEPTTAMIYRAGFSSDLYPQLALRRQKLKTAADRLNYLKDLSRSHFSSQQFKQLWRGYDYCQRRLNDVQSLPDFKIRLALGEEDFKTVISEKVPSIVFSEPFREKEYLESEYLNKHIQTKLILCGQHHYLHWSETNSILEKAKQLLSNHEKL
>CP033199.1|AYO47447.1|473110_473587_+|GNAT-family-N-acetyltransferase
MSIRLAQVTDIPVLKELLNQIFQVHQTVRPDLFKNTDKGSKYSETELKELLQDESKPIFVYTDGKNRVLGHLFLVIKETEGSSVSKPLKTLFIDDLCVSKEARGQKIGQELFEFALKYAKKLGCYDLTLNVWNDNKGALAFYERQGLKARETKMEKIL
>CP033199.1|AYO47448.1|473666_474275_+|hypothetical-protein
MPRRRASRRKSKKKAVFSILLTGITLIIIGLAVYFISAYFTNTKKTANKEKTQTHIVNPKKDPEEKKEADSSSKATSKFDLTTIATGDYSSAAGTWQNELGDQLKFNASGLESATIQNATDFTISSGQATNDGLYQATLTSADSTVVYNLLFVKGGTAIPENYFTTGYSDTSDTSRDRLYISSQTTFGSDDFSKGIFYKSEN
>CP033199.1|AYO47449.1|474339_474996_-|hypothetical-protein
MSKTQAFRSLIALLGLIGVSIQIKQFGWGMLLYYTTLSNVIVFSFLTYLVIKEKRNGSINSNPKLLRLKGGVTMTIMITFMVYHFLLAPKVRSYDYYTIRNFLVHYIVPLSTIFDTLICDRRKIYRWFDPIIWTCLPLLYFGFALINGLLLKWPIPGTADSPFPYFFINMNKYGAQQVLINALVIALLYLLFGYILLGIKQMIGQKRQVTDNSSLNMS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP033199_1	1.1\|364147\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364147-364179	33	CP033199.1	764987-765019	0	1.0

1. spacer 1.1|364147|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to position: 764987-765019, mismatch: 0, identity: 1.0

ctaataaaaaacgttcaaatggtttatggtata	CRISPR spacer
ctaataaaaaacgttcaaatggtttatggtata	Protospacer
*********************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP033199_2	2.5\|465562\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465562-465591	30	MT430910	Streptococcus phage smHBZ8, complete genome	10697-10726	0	1.0
CP033199_1	1.21\|365368\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365368-365400	33	MT430910	Streptococcus phage smHBZ8, complete genome	10958-10990	1	0.97
CP033199_1	1.5\|364391\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364391-364423	33	AM749121	Streptococcus phage M102 complete genome	30448-30480	2	0.939
CP033199_1	1.5\|364391\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364391-364423	33	NC_012884	Streptococcus phage M102, complete genome	30448-30480	2	0.939
CP033199_1	1.5\|364391\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364391-364423	33	DQ386162	Streptococcus phage M102AD, complete genome	29954-29986	2	0.939
CP033199_1	1.9\|364635\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364635-364667	33	MT430910	Streptococcus phage smHBZ8, complete genome	11154-11186	2	0.939
CP033199_1	1.12\|364818\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364818-364850	33	DQ386162	Streptococcus phage M102AD, complete genome	23069-23101	2	0.939
CP033199_1	1.14\|364940\|34\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364940-364973	34	AM749121	Streptococcus phage M102 complete genome	8231-8264	2	0.941
CP033199_1	1.14\|364940\|34\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364940-364973	34	NC_012884	Streptococcus phage M102, complete genome	8231-8264	2	0.941
CP033199_1	1.17\|365124\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365124-365156	33	MT430910	Streptococcus phage smHBZ8, complete genome	19195-19227	2	0.939
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	AM749121	Streptococcus phage M102 complete genome	22096-22128	2	0.939
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	NC_012884	Streptococcus phage M102, complete genome	22096-22128	2	0.939
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	DQ386162	Streptococcus phage M102AD, complete genome	22218-22250	2	0.939
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	MT430910	Streptococcus phage smHBZ8, complete genome	9844-9876	2	0.939
CP033199_1	1.28\|365795\|34\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365795-365828	34	AM749121	Streptococcus phage M102 complete genome	8231-8264	2	0.941
CP033199_1	1.28\|365795\|34\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365795-365828	34	NC_012884	Streptococcus phage M102, complete genome	8231-8264	2	0.941
CP033199_2	2.3\|465430\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465430-465459	30	MT430910	Streptococcus phage smHBZ8, complete genome	17736-17765	2	0.933
CP033199_2	2.5\|465562\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465562-465591	30	NC_029030	Streptococcus phage APCM01, complete genome	21406-21435	2	0.933
CP033199_1	1.6\|364452\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364452-364484	33	MT430910	Streptococcus phage smHBZ8, complete genome	16563-16595	3	0.909
CP033199_1	1.14\|364940\|34\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364940-364973	34	MT430910	Streptococcus phage smHBZ8, complete genome	23828-23861	3	0.912
CP033199_1	1.14\|364940\|34\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364940-364973	34	DQ386162	Streptococcus phage M102AD, complete genome	8353-8386	3	0.912
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	NC_029030	Streptococcus phage APCM01, complete genome	22198-22230	3	0.909
CP033199_1	1.28\|365795\|34\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365795-365828	34	MT430910	Streptococcus phage smHBZ8, complete genome	23828-23861	3	0.912
CP033199_1	1.28\|365795\|34\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365795-365828	34	DQ386162	Streptococcus phage M102AD, complete genome	8353-8386	3	0.912
CP033199_1	1.7\|364513\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364513-364545	33	AM749121	Streptococcus phage M102 complete genome	18345-18377	4	0.879
CP033199_1	1.7\|364513\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364513-364545	33	NC_012884	Streptococcus phage M102, complete genome	18345-18377	4	0.879
CP033199_1	1.7\|364513\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364513-364545	33	DQ386162	Streptococcus phage M102AD, complete genome	18467-18499	4	0.879
CP033199_1	1.17\|365124\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365124-365156	33	AM749121	Streptococcus phage M102 complete genome	12865-12897	4	0.879
CP033199_1	1.17\|365124\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365124-365156	33	NC_012884	Streptococcus phage M102, complete genome	12865-12897	4	0.879
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	NC_028671	Enterococcus phage vB_EfaS_IME197, complete genome	33034-33066	4	0.879
CP033199_1	1.11\|364757\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364757-364789	33	NC_029030	Streptococcus phage APCM01, complete genome	14360-14392	6	0.818
CP033199_1	1.22\|365429\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365429-365461	33	MT430910	Streptococcus phage smHBZ8, complete genome	11110-11142	6	0.818
CP033199_2	2.2\|465364\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465364-465393	30	KM236239	Citrobacter phage Moogle, complete genome	15791-15820	6	0.8
CP033199_2	2.2\|465364\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465364-465393	30	KY654690	Citrobacter phage Mijalis, complete genome	15791-15820	6	0.8
CP033199_2	2.3\|465430\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465430-465459	30	MH616949	Microviridae sp. isolate ctch829, complete genome	2714-2743	6	0.8
CP033199_2	2.6\|465628\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465628-465657	30	MT410774	Psychrobacillus phage Spoks, complete genome	8043-8072	6	0.8
CP033199_2	2.9\|465826\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465826-465855	30	AM749121	Streptococcus phage M102 complete genome	17557-17586	6	0.8
CP033199_2	2.9\|465826\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465826-465855	30	NC_012884	Streptococcus phage M102, complete genome	17557-17586	6	0.8
CP033199_2	2.11\|465958\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465958-465987	30	MT345684	Alteromonas phage vB_AcoS-R7M, complete genome	31659-31688	6	0.8
CP033199_2	2.12\|466024\|30\|CP033199\|CRT	466024-466053	30	AP013777	Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C94-MedDCM-OCT-S24-C128, * SEQUENCING IN PROGRESS *	2099-2128	6	0.8
CP033199_1	1.1\|364147\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364147-364179	33	NZ_CP043040	Leptospira interrogans serovar Hardjo strain L53 plasmid p1	26453-26485	7	0.788
CP033199_1	1.1\|364147\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364147-364179	33	NZ_CP006725	Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence	686-718	7	0.788
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	KX160204	Lactococcus phage 38502, complete genome	5410-5442	7	0.788
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	MN689509	Lactococcus phage CHPC1175, complete genome	27619-27651	7	0.788
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	KX160205	Lactococcus phage 49801, complete genome	7517-7549	7	0.788
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	KX160207	Lactococcus phage 53801, complete genome	33-65	7	0.788
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	MN689530	Lactococcus phage CHPC974, partial genome	25183-25215	7	0.788
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	MN534319	Lactococcus phage proPhi6, complete genome	7679-7711	7	0.788
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	KX833905	Lactococcus phage PLg-TB25, complete genome	6508-6540	7	0.788
CP033199_2	2.1\|465298\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465298-465327	30	NC_008537	Arthrobacter sp. FB24 plasmid 1, complete sequence	99934-99963	7	0.767
CP033199_2	2.1\|465298\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465298-465327	30	NC_008538	Arthrobacter sp. FB24 plasmid 2, complete sequence	43238-43267	7	0.767
CP033199_2	2.1\|465298\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465298-465327	30	NC_008539	Arthrobacter sp. FB24 plasmid 3, complete sequence	39019-39048	7	0.767
CP033199_2	2.1\|465298\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465298-465327	30	AP014065	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C13-MedDCM-OCT-S36-C38, * SEQUENCING IN PROGRESS *	5678-5707	7	0.767
CP033199_1	1.18\|365185\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365185-365217	33	MN552144	Lactococcus phage P1045, complete genome	5894-5926	8	0.758
CP033199_2	2.2\|465364\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465364-465393	30	MN694124	Marine virus AFVG_250M1008, complete genome	35798-35827	8	0.733
CP033199_2	2.2\|465364\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465364-465393	30	MN694268	Marine virus AFVG_250M110, complete genome	36089-36118	8	0.733
CP033199_2	2.10\|465892\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465892-465921	30	KY984068	Erwinia phage vB_EamM_Y3, complete genome	111144-111173	8	0.733
CP033199_2	2.12\|466024\|30\|CP033199\|CRT	466024-466053	30	KT997872	Uncultured Mediterranean phage uvDeep-CGR2-AD8-C175, complete genome	6526-6555	8	0.733
CP033199_1	1.2\|364208\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364208-364240	33	AM749121	Streptococcus phage M102 complete genome	27231-27263	9	0.727
CP033199_1	1.2\|364208\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	364208-364240	33	NC_012884	Streptococcus phage M102, complete genome	27231-27263	9	0.727
CP033199_1	1.19\|365246\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365246-365278	33	LT968167	Pseudomonas phage GP100 genome assembly, plasmid: I	10399-10431	9	0.727
CP033199_1	1.19\|365246\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365246-365278	33	LT986460	Pseudomonas phage GP100 genome assembly, chromosome: 1	10397-10429	9	0.727
CP033199_1	1.22\|365429\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365429-365461	33	MF417885	Uncultured Caudovirales phage clone 3S_9, partial genome	849-881	9	0.727
CP033199_1	1.26\|365673\|33\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	365673-365705	33	MN855659	Bacteriophage sp. isolate 142, complete genome	292-324	9	0.727
CP033199_2	2.10\|465892\|30\|CP033199\|PILER-CR,CRISPRCasFinder,CRT	465892-465921	30	NZ_CP042809	Acetobacter oryzoeni strain B6 plasmid unnamed1, complete sequence	201341-201370	9	0.7

1. spacer 2.5|465562|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 0, identity: 1.0

tacactggcacagtagctaagtttcagcac	CRISPR spacer
tacactggcacagtagctaagtttcagcac	Protospacer
******************************

2. spacer 1.21|365368|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 1, identity: 0.97

tgtgtcgacattgacacagacttaactgataac	CRISPR spacer
tgtgtcgacattgacacagacttaactaataac	Protospacer
***************************.*****

3. spacer 1.5|364391|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to AM749121 (Streptococcus phage M102 complete genome) position: , mismatch: 2, identity: 0.939

cgagtgcttgaaatccagcaaaaactcgagcaa	CRISPR spacer
cgagtgcttgaaatccaacagaaactcgagcaa	Protospacer
*****************.**.************

4. spacer 1.5|364391|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_012884 (Streptococcus phage M102, complete genome) position: , mismatch: 2, identity: 0.939

cgagtgcttgaaatccagcaaaaactcgagcaa	CRISPR spacer
cgagtgcttgaaatccaacagaaactcgagcaa	Protospacer
*****************.**.************

5. spacer 1.5|364391|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to DQ386162 (Streptococcus phage M102AD, complete genome) position: , mismatch: 2, identity: 0.939

cgagtgcttgaaatccagcaaaaactcgagcaa	CRISPR spacer
cgagtgcttgaaatccaacagaaactcgagcaa	Protospacer
*****************.**.************

6. spacer 1.9|364635|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 2, identity: 0.939

ttgcggtaatcaataaaggaaaataatgcttaa	CRISPR spacer
ttgcagtaatcaacaaaggaaaataatgcttaa	Protospacer
****.********.*******************

7. spacer 1.12|364818|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to DQ386162 (Streptococcus phage M102AD, complete genome) position: , mismatch: 2, identity: 0.939

tagcttcgaagctaaaacgcacgcgcaaaaaga	CRISPR spacer
taactttgaagctaaaacgcacgcgcaaaaaga	Protospacer
**.***.**************************

8. spacer 1.14|364940|34|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to AM749121 (Streptococcus phage M102 complete genome) position: , mismatch: 2, identity: 0.941

atggaaagcgcaagaaagagcgcttgaacaatcc	CRISPR spacer
gtggaaagcgcaagaaagagcgctcgaacaatcc	Protospacer
.***********************.*********

9. spacer 1.14|364940|34|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_012884 (Streptococcus phage M102, complete genome) position: , mismatch: 2, identity: 0.941

atggaaagcgcaagaaagagcgcttgaacaatcc	CRISPR spacer
gtggaaagcgcaagaaagagcgctcgaacaatcc	Protospacer
.***********************.*********

10. spacer 1.17|365124|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 2, identity: 0.939

tatagttgatagccgctaacaagttatcatagc	CRISPR spacer
tgtagttgatagcagctaacaagttatcatagc	Protospacer
*.*********** *******************

11. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to AM749121 (Streptococcus phage M102 complete genome) position: , mismatch: 2, identity: 0.939

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggacacacaggtaaggataggtaaggatagat	Protospacer
.**************** ***************

12. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_012884 (Streptococcus phage M102, complete genome) position: , mismatch: 2, identity: 0.939

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggacacacaggtaaggataggtaaggatagat	Protospacer
.**************** ***************

13. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to DQ386162 (Streptococcus phage M102AD, complete genome) position: , mismatch: 2, identity: 0.939

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggacacacaggtaaggataggtaaggatagat	Protospacer
.**************** ***************

14. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 2, identity: 0.939

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
cggacacgcaggtaaggttagataaggatagat	Protospacer
*******.*************.***********

15. spacer 1.28|365795|34|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to AM749121 (Streptococcus phage M102 complete genome) position: , mismatch: 2, identity: 0.941

atggaaagcgcaagaaagagcgcttgaacaatcc	CRISPR spacer
gtggaaagcgcaagaaagagcgctcgaacaatcc	Protospacer
.***********************.*********

16. spacer 1.28|365795|34|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_012884 (Streptococcus phage M102, complete genome) position: , mismatch: 2, identity: 0.941

atggaaagcgcaagaaagagcgcttgaacaatcc	CRISPR spacer
gtggaaagcgcaagaaagagcgctcgaacaatcc	Protospacer
.***********************.*********

17. spacer 2.3|465430|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 2, identity: 0.933

cccatcaggttttgagccaataaacttata	CRISPR spacer
cccatcaggctttgagccaataaatttata	Protospacer
*********.**************.*****

18. spacer 2.5|465562|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_029030 (Streptococcus phage APCM01, complete genome) position: , mismatch: 2, identity: 0.933

tacactggcacagtagctaagtttcagcac	CRISPR spacer
tacactggcacagtagctaagtttatgcac	Protospacer
************************  ****

19. spacer 1.6|364452|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 3, identity: 0.909

ctccgctgagaaatacacgattatacatctcat	CRISPR spacer
caccgctgagaaaaacacgattgtacatctcat	Protospacer
* *********** ********.**********

20. spacer 1.14|364940|34|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 3, identity: 0.912

atggaaagcgcaagaaagagcgcttgaacaatcc	CRISPR spacer
gtggaaagcacaagaaagagcgcttgagcaatcc	Protospacer
.********.*****************.******

21. spacer 1.14|364940|34|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to DQ386162 (Streptococcus phage M102AD, complete genome) position: , mismatch: 3, identity: 0.912

atggaaagcgcaagaaagagcgcttgaacaatcc	CRISPR spacer
gtggaaagcgcaagaaagagcgttcgaacaatcc	Protospacer
.*********************.*.*********

22. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_029030 (Streptococcus phage APCM01, complete genome) position: , mismatch: 3, identity: 0.909

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggacacacaggtaaggttagagaaggatagat	Protospacer
.********************. **********

23. spacer 1.28|365795|34|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 3, identity: 0.912

atggaaagcgcaagaaagagcgcttgaacaatcc	CRISPR spacer
gtggaaagcacaagaaagagcgcttgagcaatcc	Protospacer
.********.*****************.******

24. spacer 1.28|365795|34|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to DQ386162 (Streptococcus phage M102AD, complete genome) position: , mismatch: 3, identity: 0.912

atggaaagcgcaagaaagagcgcttgaacaatcc	CRISPR spacer
gtggaaagcgcaagaaagagcgttcgaacaatcc	Protospacer
.*********************.*.*********

25. spacer 1.7|364513|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to AM749121 (Streptococcus phage M102 complete genome) position: , mismatch: 4, identity: 0.879

acgttttgcagttggaaaaatcactgacaacaa	CRISPR spacer
gcgctttgcagttggaaaaatcactgataacag	Protospacer
.**.***********************.****.

26. spacer 1.7|364513|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_012884 (Streptococcus phage M102, complete genome) position: , mismatch: 4, identity: 0.879

acgttttgcagttggaaaaatcactgacaacaa	CRISPR spacer
gcgctttgcagttggaaaaatcactgataacag	Protospacer
.**.***********************.****.

27. spacer 1.7|364513|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to DQ386162 (Streptococcus phage M102AD, complete genome) position: , mismatch: 4, identity: 0.879

acgttttgcagttggaaaaatcactgacaacaa	CRISPR spacer
gcgctttgcagttggaaaaatcactgataacag	Protospacer
.**.***********************.****.

28. spacer 1.17|365124|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to AM749121 (Streptococcus phage M102 complete genome) position: , mismatch: 4, identity: 0.879

tatagttgatagccgctaacaagttatcatagc	CRISPR spacer
tgtagttgatagctgctaacaggttatcatatc	Protospacer
*.***********.*******.********* *

29. spacer 1.17|365124|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_012884 (Streptococcus phage M102, complete genome) position: , mismatch: 4, identity: 0.879

tatagttgatagccgctaacaagttatcatagc	CRISPR spacer
tgtagttgatagctgctaacaggttatcatatc	Protospacer
*.***********.*******.********* *

30. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_028671 (Enterococcus phage vB_EfaS_IME197, complete genome) position: , mismatch: 4, identity: 0.879

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggatacacaggttaggttaggtaaggataggt	Protospacer
.***.******** *****************.*

31. spacer 1.11|364757|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_029030 (Streptococcus phage APCM01, complete genome) position: , mismatch: 6, identity: 0.818

cgggaaattactgtatggagtagaaacgcttaa	CRISPR spacer
tggaaaactactgtatggagtagaaacattgaa	Protospacer
.**.***.*******************..* **

32. spacer 1.22|365429|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT430910 (Streptococcus phage smHBZ8, complete genome) position: , mismatch: 6, identity: 0.818

tggttttaggtctatctgctagtttattgattg	CRISPR spacer
caattttaggtttatcagctagtttattgatta	Protospacer
...********.**** ***************.

33. spacer 2.2|465364|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to KM236239 (Citrobacter phage Moogle, complete genome) position: , mismatch: 6, identity: 0.8

aacttcttcagctgtcagccttttagcgtt	CRISPR spacer
gatttcttctgctgtcagctttttagtttt	Protospacer
.*.****** *********.******. **

34. spacer 2.2|465364|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to KY654690 (Citrobacter phage Mijalis, complete genome) position: , mismatch: 6, identity: 0.8

aacttcttcagctgtcagccttttagcgtt	CRISPR spacer
gatttcttctgctgtcagctttttagtttt	Protospacer
.*.****** *********.******. **

35. spacer 2.3|465430|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MH616949 (Microviridae sp. isolate ctch829, complete genome) position: , mismatch: 6, identity: 0.8

cccatcaggttttgagccaataaacttata	CRISPR spacer
tgtatcaggttttgagccaatgagcttaca	Protospacer
. .******************.*.****.*

36. spacer 2.6|465628|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT410774 (Psychrobacillus phage Spoks, complete genome) position: , mismatch: 6, identity: 0.8

-ctaactctccaaaagatatcatctgtcagt	CRISPR spacer
ggtaaat-tccaaaagatatcatccgtcata	Protospacer
  *** * ****************.****

37. spacer 2.9|465826|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to AM749121 (Streptococcus phage M102 complete genome) position: , mismatch: 6, identity: 0.8

tctttctgttacatgctccagaaagtcaat	CRISPR spacer
tcgatctgttgcatgctccagaaaatcgag	Protospacer
**  ******.*************.**.*

38. spacer 2.9|465826|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_012884 (Streptococcus phage M102, complete genome) position: , mismatch: 6, identity: 0.8

tctttctgttacatgctccagaaagtcaat	CRISPR spacer
tcgatctgttgcatgctccagaaaatcgag	Protospacer
**  ******.*************.**.*

39. spacer 2.11|465958|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MT345684 (Alteromonas phage vB_AcoS-R7M, complete genome) position: , mismatch: 6, identity: 0.8

tatagcgcttattgacagcg-aagcgacaaa	CRISPR spacer
tataccgcttattgacagcgaaaatgacgg-	Protospacer
**** *************** **..***..

40. spacer 2.12|466024|30|CP033199|CRT matches to AP013777 (Uncultured Mediterranean phage uvMED isolate uvMED-CGF-C94-MedDCM-OCT-S24-C128, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 6, identity: 0.8

aatagaatcaaattctcctaagtcagttaa	CRISPR spacer
agtagaatcaaattcaccaaagtcagtagg	Protospacer
*.************* ** ******** ..

41. spacer 1.1|364147|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP043040 (Leptospira interrogans serovar Hardjo strain L53 plasmid p1) position: , mismatch: 7, identity: 0.788

ctaataaaaaacgttcaaatggtttatggtata	CRISPR spacer
agattaaaaaacgttcaaatgctttatgctttt	Protospacer
  * ***************** ****** * *

42. spacer 1.1|364147|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP006725 (Leptospira interrogans serovar Linhai str. 56609 plasmid lcp1, complete sequence) position: , mismatch: 7, identity: 0.788

ctaataaaaaacgttcaaatggtttatggtata	CRISPR spacer
agattaaaaaacgttcaaatgctttatgctttt	Protospacer
  * ***************** ****** * *

43. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to KX160204 (Lactococcus phage 38502, complete genome) position: , mismatch: 7, identity: 0.788

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggatacacaggtaaggttaggtaagagtaagg	Protospacer
.***.*********************..**..

44. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MN689509 (Lactococcus phage CHPC1175, complete genome) position: , mismatch: 7, identity: 0.788

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggatacacaggtaaggttaggtaagagtaagg	Protospacer
.***.*********************..**..

45. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to KX160205 (Lactococcus phage 49801, complete genome) position: , mismatch: 7, identity: 0.788

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggatacacaggtaaggttaggtaagagtaagg	Protospacer
.***.*********************..**..

46. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to KX160207 (Lactococcus phage 53801, complete genome) position: , mismatch: 7, identity: 0.788

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggatacacaggtaaggttaggtaagagtaagg	Protospacer
.***.*********************..**..

47. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MN689530 (Lactococcus phage CHPC974, partial genome) position: , mismatch: 7, identity: 0.788

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggatacacaggtaaggttaggtaagagtaagg	Protospacer
.***.*********************..**..

48. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MN534319 (Lactococcus phage proPhi6, complete genome) position: , mismatch: 7, identity: 0.788

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggatacacaggtaaggttaggtaagagtaagg	Protospacer
.***.*********************..**..

49. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to KX833905 (Lactococcus phage PLg-TB25, complete genome) position: , mismatch: 7, identity: 0.788

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tgtccgcacaggataggttaggtaaggataggt	Protospacer
.*  *.******  *****************.*

50. spacer 2.1|465298|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_008537 (Arthrobacter sp. FB24 plasmid 1, complete sequence) position: , mismatch: 7, identity: 0.767

agagccggaaacagcagaaggacaggctca	CRISPR spacer
taagccggaaacagaagaaggccaggaaga	Protospacer
 .************ ****** ****   *

51. spacer 2.1|465298|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_008538 (Arthrobacter sp. FB24 plasmid 2, complete sequence) position: , mismatch: 7, identity: 0.767

agagccggaaacagcagaaggacaggctca	CRISPR spacer
taagccggaaacagaagaaggccaggaaga	Protospacer
 .************ ****** ****   *

52. spacer 2.1|465298|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_008539 (Arthrobacter sp. FB24 plasmid 3, complete sequence) position: , mismatch: 7, identity: 0.767

agagccggaaacagcagaaggacaggctca	CRISPR spacer
taagccggaaacagaagaaggccaggaaga	Protospacer
 .************ ****** ****   *

53. spacer 2.1|465298|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to AP014065 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C13-MedDCM-OCT-S36-C38, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.767

agagccggaaacagcagaaggacaggctca-	CRISPR spacer
agagccggaaaccgcagaagg-caaatgcgc	Protospacer
************ ******** **... *.

54. spacer 1.18|365185|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MN552144 (Lactococcus phage P1045, complete genome) position: , mismatch: 8, identity: 0.758

cggacacacaggtaaggttaggtaaggatagat	CRISPR spacer
tggatacacaggtaaggctaggtaagagtaagg	Protospacer
.***.************.********..**..

55. spacer 2.2|465364|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MN694124 (Marine virus AFVG_250M1008, complete genome) position: , mismatch: 8, identity: 0.733

aacttcttcagctgtcagccttttagcgtt	CRISPR spacer
tgcttctttagctggcagccttttacatat	Protospacer
 .******.***** **********    *

56. spacer 2.2|465364|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MN694268 (Marine virus AFVG_250M110, complete genome) position: , mismatch: 8, identity: 0.733

aacttcttcagctgtcagccttttagcgtt	CRISPR spacer
tgcttctttagctggcagccttttacatat	Protospacer
 .******.***** **********    *

57. spacer 2.10|465892|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to KY984068 (Erwinia phage vB_EamM_Y3, complete genome) position: , mismatch: 8, identity: 0.733

taaaacaactgaaaaagggacgtttgtcga	CRISPR spacer
tggaacaactgaaaaagagacgttcaaggt	Protospacer
*..**************.******..  *

58. spacer 2.12|466024|30|CP033199|CRT matches to KT997872 (Uncultured Mediterranean phage uvDeep-CGR2-AD8-C175, complete genome) position: , mismatch: 8, identity: 0.733

aatagaatcaaattctcctaagtcagttaa	CRISPR spacer
gtcagaatcaaattctccaaagtcagaagc	Protospacer
. .*************** *******  .

59. spacer 1.2|364208|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to AM749121 (Streptococcus phage M102 complete genome) position: , mismatch: 9, identity: 0.727

ctgcaatgcaagagctgataaatgaaaaacata	CRISPR spacer
taaagttgcaagagctgataaatacaaaacaca	Protospacer
. . . *****************. ******.*

60. spacer 1.2|364208|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NC_012884 (Streptococcus phage M102, complete genome) position: , mismatch: 9, identity: 0.727

ctgcaatgcaagagctgataaatgaaaaacata	CRISPR spacer
taaagttgcaagagctgataaatacaaaacaca	Protospacer
. . . *****************. ******.*

61. spacer 1.19|365246|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to LT968167 (Pseudomonas phage GP100 genome assembly, plasmid: I) position: , mismatch: 9, identity: 0.727

tttggttattagtcttgtaatcatctgcttgtg	CRISPR spacer
agtggttattcgtcttgtcatcatctatgtggt	Protospacer
  ******** ******* *******.. **

62. spacer 1.19|365246|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to LT986460 (Pseudomonas phage GP100 genome assembly, chromosome: 1) position: , mismatch: 9, identity: 0.727

tttggttattagtcttgtaatcatctgcttgtg	CRISPR spacer
agtggttattcgtcttgtcatcatctatgtggt	Protospacer
  ******** ******* *******.. **

63. spacer 1.22|365429|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MF417885 (Uncultured Caudovirales phage clone 3S_9, partial genome) position: , mismatch: 9, identity: 0.727

tggttttaggtctatctgctagtttattgattg	CRISPR spacer
gtgctttaggtctttctgctactttatttcgtt	Protospacer
  *.********* ******* ******   *

64. spacer 1.26|365673|33|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to MN855659 (Bacteriophage sp. isolate 142, complete genome) position: , mismatch: 9, identity: 0.727

taataagccagccgatagtcctaaaattgttaa	CRISPR spacer
ttttggtacagttgatagtcctaaaattgttac	Protospacer
*  *..  ***..*******************

65. spacer 2.10|465892|30|CP033199|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP042809 (Acetobacter oryzoeni strain B6 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.7

taaaacaactgaaaaagggacgtttgtcga	CRISPR spacer
cgggcgcacggaaaaagggaggtttgtcga	Protospacer
....   ** ********** *********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

202471 : 208323

Streptococcus_phage(71.43%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYO47220.1\|202471_203236_+	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.6e-16	26.4
AYO47221.1\|203235_203946_+	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	1.8e-14	26.9
AYO47222.1\|204060_204720_+	CBS domain-containing protein	M1NSC5	Streptococcus_phage	8.6e-67	60.6
AYO47223.1\|204796_205435_+	dTMP kinase	M1PSC7	Streptococcus_phage	1.3e-75	65.1
AYO47224.1\|205447_206323_+	DNA polymerase III subunit delta'	M1NSC1	Streptococcus_phage	7.6e-79	54.1
AYO47225.1\|206319_207126_+	signal peptidase II	NA	NA	NA	NA
AYO47226.1\|207118_207451_+	DNA replication initiation control protein YabA	M1PFV3	Streptococcus_phage	6.1e-29	58.2
AYO47227.1\|207456_208323_+	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	M1PLC5	Streptococcus_phage	1.3e-115	73.9

DBSCAN-SWA_2

768525 : 777309

Bacillus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYO47679.1\|768525_769116_+	threonylcarbamoyl-AMP synthase	A0A291ATS8	Pandoravirus	1.1e-15	33.2
AYO47680.1\|769125_770388_+	serine hydroxymethyltransferase	A0A219YB23	Aeromonas_phage	1.3e-98	52.1
AYO47681.1\|770384_771362_+	nucleoid-associated protein	NA	NA	NA	NA
AYO47682.1\|771363_771978_+	lysozyme family protein	A0A223LKM8	Bacillus_phage	1.2e-22	37.6
AYO47683.1\|771987_773721_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.1e-39	25.8
AYO47684.1\|773717_775463_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	2.2e-53	29.2
AYO47685.1\|775593_777309_-	phospho-sugar mutase	A0A1X9I671	Streptococcus_phage	9.8e-272	82.5

DBSCAN-SWA_3

915569 : 922419

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYO47808.1\|915569_917324_-	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	7.9e-43	27.8
AYO47809.1\|917313_919116_-	ABC transporter ATP-binding protein	F2Y302	Organic_Lake_phycodnavirus	1.4e-18	30.7
AYO47810.1\|919119_919554_-	MarR family transcriptional regulator	NA	NA	NA	NA
AYO47811.1\|920105_920759_+	7-cyano-7-deazaguanine synthase QueC	A0A2H4J8Q7	uncultured_Caudovirales_phage	7.7e-60	52.4
AYO47812.1\|920758_921205_+	6-carboxytetrahydropterin synthase QueD	J9PV91	Bacillus_phage	1.1e-41	60.6
AYO47813.1\|921186_921918_+	7-carboxy-7-deazaguanine synthase QueE	E7DN68	Pneumococcus_phage	6.4e-63	48.4
AYO47814.1\|921930_922419_+	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF	E7DN65	Pneumococcus_phage	1.1e-45	57.2

DBSCAN-SWA_4

1729193 : 1740794

Streptococcus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYO48516.1\|1729193_1729799_-	lytic transglycosylase domain-containing protein	Q4Z8Z7	Staphylococcus_phage	5.5e-28	62.2
AYO48517.1\|1729960_1730827_-	LysM peptidoglycan-binding domain-containing protein	A0A288TY55	Enterococcus_phage	1.3e-22	75.7
AYO48518.1\|1731015_1731810_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
AYO48519.1\|1731802_1732645_-	energy-coupling factor transporter ATPase	W6JKT0	Anomala_cuprea_entomopoxvirus	8.0e-17	23.6
AYO48520.1\|1732620_1733463_-	energy-coupling factor transporter ATPase	G9BWD6	Planktothrix_phage	1.1e-21	30.0
AYO48521.1\|1733466_1734009_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
AYO48522.1\|1734020_1734998_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
AYO48523.1\|1735070_1736363_-	insulinase family protein	A0A0G2Y5U8	Acanthamoeba_polyphaga_mimivirus	1.3e-18	34.1
AYO48524.1\|1736364_1737612_-	insulinase family protein	A0A1X9I714	Streptococcus_phage	2.5e-99	45.4
AYO48525.1\|1737690_1738056_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	5.3e-18	57.3
AYO48526.1\|1738058_1739150_+	DNA replication/repair protein RecF	NA	NA	NA	NA
AYO48527.1\|1739312_1740794_-	IMP dehydrogenase	A0A1V0SHK8	Klosneuvirus	2.6e-95	40.3

DBSCAN-SWA_5

1784148 : 1799070

Microbacterium_phage(11.11%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYO48554.1\|1784148_1787874_+	phosphoribosylformylglycinamidine synthase	A6N228	Microbacterium_phage	2.3e-39	26.6
AYO48555.1\|1787895_1788516_+	phosphomethylpyrimidine kinase	NA	NA	NA	NA
AYO48556.1\|1788541_1789981_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	6.3e-54	32.9
AYO48876.1\|1790197_1790479_+	hypothetical protein	NA	NA	NA	NA
AYO48557.1\|1790523_1791546_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SE90	Cyanophage	3.4e-62	43.6
AYO48558.1\|1791545_1792091_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.0e-24	38.7
AYO48559.1\|1792136_1793036_+	exonuclease	B5WZL1	Staphylococcus_phage	5.9e-34	33.4
AYO48877.1\|1793125_1793350_+	hypothetical protein	NA	NA	NA	NA
AYO48560.1\|1793297_1794848_+	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PurH	E3SNU8	Prochlorococcus_phage	1.1e-48	53.9
AYO48561.1\|1795030_1795573_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
AYO48562.1\|1795740_1796250_+	HXXEE domain-containing protein	NA	NA	NA	NA
AYO48563.1\|1796426_1796588_+	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	A0A1S5S8E8	Streptococcus_phage	1.7e-08	53.2
AYO48564.1\|1796571_1796673_+	hypothetical protein	NA	NA	NA	NA
AYO48565.1\|1796739_1797615_+	Abi family protein	A3QSC6	Clostridium_virus	1.0e-38	35.4
AYO48566.1\|1797690_1799070_+	DNA methyltransferase	A0A2H4UTH8	Bodo_saltans_virus	3.2e-07	23.2

DBSCAN-SWA_6

2013342 : 2066358

Bacillus_phage(27.27%)

protease,tRNA,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AYO48739.1\|2013342_2015844_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	65.2
AYO48740.1\|2016570_2019447_+	type 2 lantipeptide synthetase LanM	NA	NA	NA	NA
AYO48741.1\|2019457_2020282_+	ABC transporter ATP-binding protein	Q9EMR9	Amsacta_moorei_entomopoxvirus	5.2e-13	25.0
AYO48742.1\|2020271_2020988_+	ABC transporter permease	NA	NA	NA	NA
AYO48743.1\|2020987_2023603_+	DUF4135 domain-containing protein	NA	NA	NA	NA
AYO48744.1\|2023639_2025736_+	peptidase domain-containing ABC transporter	W8CYL7	Bacillus_phage	1.0e-20	25.7
AYO48745.1\|2025834_2026023_+	hypothetical protein	NA	NA	NA	NA
AYO48746.1\|2026050_2026239_+	plantaricin C family lantibiotic	NA	NA	NA	NA
AYO48747.1\|2028118_2028922_+	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
AYO48748.1\|2029088_2029931_+	MetQ/NlpA family ABC transporter substrate-binding protein	NA	NA	NA	NA
AYO48749.1\|2030125_2031499_+	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
AYO48750.1\|2031491_2032556_+	methionine ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.5e-28	36.6
AYO48751.1\|2032557_2033247_+	ABC transporter permease	NA	NA	NA	NA
AYO48752.1\|2033314_2034091_+	carbon-nitrogen family hydrolase	NA	NA	NA	NA
AYO48753.1\|2034214_2035060_+	DNA-directed RNA polymerase subunit delta	NA	NA	NA	NA
AYO48754.1\|2035069_2035615_+	ECF-type riboflavin transporter substrate-binding protein	NA	NA	NA	NA
AYO48755.1\|2035643_2037320_+	ATP-binding cassette domain-containing protein	G9BWD6	Planktothrix_phage	1.1e-17	30.0
AYO48756.1\|2037312_2038146_+	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
AYO48757.1\|2038369_2039083_-	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	NA	NA	NA	NA
AYO48758.1\|2039170_2039731_+	LemA family protein	A0A1X9IGG1	Lactococcus_phage	9.7e-11	30.1
AYO48759.1\|2039740_2040640_+\|protease	zinc metalloprotease HtpX	NA	NA	NA	NA
AYO48760.1\|2043389_2044097_-	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.8e-30	38.1
AYO48761.1\|2044204_2044780_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
AYO48762.1\|2044772_2045309_+	DUF177 domain-containing protein	NA	NA	NA	NA
AYO48763.1\|2045665_2046358_+	DNA-binding response regulator	W8CYM9	Bacillus_phage	5.9e-26	30.9
AYO48764.1\|2046727_2047219_+	transcriptional regulator NrdR	NA	NA	NA	NA
AYO48765.1\|2048374_2049274_+	primosomal protein DnaI	S5MU12	Brevibacillus_phage	1.2e-26	30.9
AYO48766.1\|2049286_2050597_+	ribosome biogenesis GTPase Der	NA	NA	NA	NA
AYO48767.1\|2050671_2051298_+	ribonuclease P	NA	NA	NA	NA
AYO48768.1\|2051344_2051983_+	cytochrome O ubiquinol oxidase	NA	NA	NA	NA
AYO48769.1\|2052453_2053206_+	DNA-binding response regulator	A0A1V0E029	Clostridioides_phage	1.2e-16	26.7
AYO48770.1\|2053202_2054528_+	GHKL domain-containing protein	NA	NA	NA	NA
AYO48771.1\|2054669_2054810_-\|bacteriocin	ComC/BlpC family peptide pheromone/bacteriocin	NA	NA	NA	NA
AYO48772.1\|2055074_2055305_+\|bacteriocin	ComC/BlpC family peptide pheromone/bacteriocin	NA	NA	NA	NA
AYO48773.1\|2055435_2055837_+	hypothetical protein	NA	NA	NA	NA
AYO48774.1\|2056247_2056403_+	hypothetical protein	NA	NA	NA	NA
AYO48775.1\|2057217_2057637_+	hypothetical protein	NA	NA	NA	NA
AYO48776.1\|2058183_2058537_-	hypothetical protein	NA	NA	NA	NA
AYO48777.1\|2058961_2059126_+	hypothetical protein	NA	NA	NA	NA
AYO48778.1\|2059319_2059451_-	hypothetical protein	NA	NA	NA	NA
AYO48779.1\|2059530_2059743_+	hypothetical protein	NA	NA	NA	NA
AYO48780.1\|2059906_2060095_+\|bacteriocin	ComC/BlpC family peptide pheromone/bacteriocin	NA	NA	NA	NA
AYO48781.1\|2060580_2061603_+	thiol reductase thioredoxin	NA	NA	NA	NA
AYO48782.1\|2061675_2061828_+	hypothetical protein	NA	NA	NA	NA
AYO48783.1\|2061894_2062038_+	hypothetical protein	NA	NA	NA	NA
AYO48784.1\|2063421_2065086_-	peptide cleavage/export ABC transporter	W8CYL7	Bacillus_phage	4.7e-37	25.9
AYO48785.1\|2065027_2065510_-	competence protein	NA	NA	NA	NA
AYO48884.1\|2065897_2066152_+\|bacteriocin	ComC/BlpC family peptide pheromone/bacteriocin	NA	NA	NA	NA
AYO48786.1\|2066196_2066358_+\|bacteriocin	ComC/BlpC family peptide pheromone/bacteriocin	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP033199

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection