CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Prophage number
CP033947	Klebsiella pneumoniae subsp. pneumoniae strain ARLG-3135 plasmid p1, complete sequence	0 crisprs	RT	1
CP033952	Klebsiella pneumoniae subsp. pneumoniae strain ARLG-3135 plasmid p6, complete sequence	0 crisprs	NA	0
CP033946	Klebsiella pneumoniae subsp. pneumoniae strain ARLG-3135 chromosome, complete genome	3 crisprs	csa3,cas3,DEDDh,DinG,WYL	6
CP033950	Klebsiella pneumoniae subsp. pneumoniae strain ARLG-3135 plasmid p4, complete sequence	0 crisprs	NA	0
CP033951	Klebsiella pneumoniae subsp. pneumoniae strain ARLG-3135 plasmid p5, complete sequence	0 crisprs	NA	0
CP033949	Klebsiella pneumoniae subsp. pneumoniae strain ARLG-3135 plasmid p3, complete sequence	0 crisprs	NA	0
CP033948	Klebsiella pneumoniae subsp. pneumoniae strain ARLG-3135 plasmid p2, complete sequence	0 crisprs	NA	1

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

11258 : 61815

Escherichia_phage(29.63%)

integrase,transposase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZB79617.1\|11258_12527_+\|transposase	ISL3-like element ISKpn25 family transposase	Q6V7R1	Burkholderia_virus	5.2e-60	34.7
AZB79618.1\|12646_13120_+	YkgJ family cysteine cluster protein	NA	NA	NA	NA
AZB79619.1\|13284_13479_+	hypothetical protein	NA	NA	NA	NA
AZB79620.1\|14333_15116_-\|integrase	phage integrase family protein	I3WFA4	Macacine_betaherpesvirus	4.6e-51	90.2
AZB79621.1\|15115_15448_-	hypothetical protein	NA	NA	NA	NA
AZB79755.1\|15454_15811_-	hypothetical protein	NA	NA	NA	NA
AZB79622.1\|15878_16208_-	hypothetical protein	NA	NA	NA	NA
AZB79623.1\|16235_16544_-	hypothetical protein	NA	NA	NA	NA
AZB79756.1\|16589_16796_-	hypothetical protein	NA	NA	NA	NA
AZB79624.1\|17441_18011_+	hypothetical protein	NA	NA	NA	NA
AZB79625.1\|18151_19180_+	hypothetical protein	NA	NA	NA	NA
AZB79626.1\|19324_22129_-	hypothetical protein	NA	NA	NA	NA
AZB79627.1\|22713_24306_-\|transposase	IS66-like element ISKox1 family transposase	A0A0P0ZEB3	Stx2-converting_phage	3.6e-175	61.4
AZB79628.1\|24336_24687_-	IS66 family insertion sequence hypothetical protein	A0A0P0ZBY2	Stx2-converting_phage	5.2e-39	63.8
AZB79629.1\|24683_25124_-	IS66 family insertion sequence hypothetical protein	Q6H9S5	Enterobacteria_phage	2.6e-19	60.3
AZB79630.1\|25804_26587_-	AAA family ATPase	A0A2L1IVB6	Escherichia_phage	6.1e-136	96.5
AZB79631.1\|26583_27606_-\|transposase	IS21-like element ISSen3 family transposase	A0A2L1IVA1	Escherichia_phage	8.7e-175	85.6
AZB79632.1\|28635_30363_-	hypothetical protein	NA	NA	NA	NA
AZB79633.1\|30808_31057_+	hypothetical protein	NA	NA	NA	NA
AZB79634.1\|31053_31626_+	hypothetical protein	NA	NA	NA	NA
AZB79635.1\|31656_32151_+	DNA-binding protein	NA	NA	NA	NA
AZB79636.1\|32194_32494_+	hypothetical protein	NA	NA	NA	NA
AZB79757.1\|32383_32692_-	hypothetical protein	NA	NA	NA	NA
AZB79637.1\|32817_33054_+	hypothetical protein	NA	NA	NA	NA
AZB79638.1\|33185_33734_+	thioredoxin-like domain protein	NA	NA	NA	NA
AZB79639.1\|33780_34215_+	cell envelope integrity protein TolA	NA	NA	NA	NA
AZB79640.1\|34443_35975_-\|transposase	IS3-like element ISKpn38 family transposase	A0A1B1P773	Bacillus_phage	9.0e-51	39.8
AZB79641.1\|36287_36611_-	hypothetical protein	NA	NA	NA	NA
AZB79642.1\|36683_37679_-	hypothetical protein	A0A2H4UVR4	Bodo_saltans_virus	2.1e-32	34.9
AZB79643.1\|37975_38626_-	SOS response-associated peptidase	A0A2H4J5W2	uncultured_Caudovirales_phage	1.8e-77	60.6
AZB79644.1\|38672_39014_-	recombinase family protein	A0A219Y912	Aeromonas_phage	3.4e-19	50.0
AZB79645.1\|39126_39831_+\|transposase	IS6 family transposase IS15DIV	A0A077SL39	Escherichia_phage	1.8e-139	100.0
AZB79646.1\|39950_40610_-	type A-1 chloramphenicol O-acetyltransferase	G3CFL0	Escherichia_phage	8.4e-131	100.0
AZB79647.1\|40663_40855_+	hypothetical protein	NA	NA	NA	NA
AZB79648.1\|41520_42177_-	hypothetical protein	A0A2L1IV26	Escherichia_phage	1.7e-06	100.0
AZB79649.1\|42412_42742_+	type II toxin-antitoxin system RelE/ParE family toxin	A0A088CBP5	Shigella_phage	2.4e-09	44.2
AZB79650.1\|42722_43004_+	XRE family transcriptional regulator	A0A2I6TC97	Escherichia_phage	1.3e-08	38.0
AZB79651.1\|45296_46001_+\|transposase	IS6 family transposase IS15DIV	A0A077SL39	Escherichia_phage	1.8e-139	100.0
AZB79652.1\|46321_47584_-\|transposase	IS1380 family transposase ISEc9	A0A1B0VDR3	Salmonella_phage	1.3e-39	100.0
AZB79653.1\|48147_48705_+	recombinase family protein	Q1MVP4	Enterobacteria_phage	7.0e-94	100.0
AZB79654.1\|48887_49748_+	class A broad-spectrum beta-lactamase TEM-1	Q1MVP3	Enterobacteria_phage	4.6e-161	100.0
AZB79655.1\|50993_51650_+	quinolone resistance pentapeptide repeat protein QnrS1	NA	NA	NA	NA
AZB79758.1\|52429_53821_-\|transposase	ISKra4-like element ISKpn19 family transposase	NA	NA	NA	NA
AZB79656.1\|53857_54430_-	recombinase family protein	M9Q1K0	Clostridium_phage	3.4e-19	39.4
AZB79657.1\|54566_55157_-	plasmid pRiA4b ORF-3 family protein	NA	NA	NA	NA
AZB79658.1\|55220_55868_+	DNA polymerase V subunit UmuC	F1C5A5	Cronobacter_phage	3.9e-48	48.3
AZB79659.1\|56015_57413_-	HAMP domain-containing protein	A0A1B0V854	Salmonella_phage	1.1e-58	99.2
AZB79660.1\|57479_58184_-\|transposase	IS6 family transposase IS15DIV	A0A077SL39	Escherichia_phage	1.8e-139	100.0
AZB79661.1\|58506_58668_+\|transposase	Tn3 family transposase	A0A1B0V7H9	Salmonella_phage	4.7e-11	72.7
AZB79759.1\|58589_58874_-\|transposase	transposase	NA	NA	NA	NA
AZB79662.1\|58842_59856_-\|integrase	class 1 integron integrase IntI1	A0A1P8DJJ6	Virus_Rctr41k	1.0e-71	45.5
AZB79663.1\|60028_60481_+	NAD(+)--rifampin ADP-ribosyltransferase Arr-2	NA	NA	NA	NA
AZB79760.1\|60561_61815_-	group II intron reverse transcriptase/maturase	H7BVN7	unidentified_phage	3.0e-12	29.7

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. CP033948

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1796 : 53758

Escherichia_phage(30.0%)

transposase,integrase,protease

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZB79775.1\|1796_2450_+\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
AZB79776.1\|2542_2800_+	antitoxin PemI	NA	NA	NA	NA
AZB79777.1\|2801_3134_+	mRNA interferase PemK	NA	NA	NA	NA
AZB79778.1\|3429_4134_-\|transposase	IS6 family transposase IS15DIV	A0A077SL39	Escherichia_phage	1.8e-139	100.0
AZB79779.1\|4145_5627_-\|transposase	IS91 family transposase	NA	NA	NA	NA
AZB79780.1\|6155_6605_-	hypothetical protein	NA	NA	NA	NA
AZB79781.1\|7119_7230_-	hypothetical protein	E4ZFP9	Streptococcus_phage	1.9e-08	88.6
AZB79782.1\|7234_7972_-	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	E4ZFQ0	Streptococcus_phage	6.3e-135	99.6
AZB79783.1\|8097_8193_-	23S rRNA methyltransferase attenuation leader peptide	NA	NA	NA	NA
AZB79784.1\|8327_9032_+\|transposase	IS6 family transposase IS15DIV	A0A077SL39	Escherichia_phage	1.8e-139	100.0
AZB79785.1\|9153_10059_+	Mph(A) family macrolide 2'-phosphotransferase	NA	NA	NA	NA
AZB79786.1\|10055_11294_+	MFS transporter	NA	NA	NA	NA
AZB79787.1\|11293_11878_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
AZB79788.1\|11823_12180_+	hypothetical protein	NA	NA	NA	NA
AZB79789.1\|12370_13135_-\|transposase	IS6-like element IS6100 family transposase	A0A077SL39	Escherichia_phage	4.3e-86	65.7
AZB79790.1\|13163_13346_+	resolvase	NA	NA	NA	NA
AZB79791.1\|13361_13667_-	PadR family transcriptional regulator	NA	NA	NA	NA
AZB79792.1\|13677_14883_-	chromate efflux transporter	NA	NA	NA	NA
AZB79793.1\|15038_15242_-	hypothetical protein	NA	NA	NA	NA
AZB79794.1\|15260_15440_+	hypothetical protein	NA	NA	NA	NA
AZB79795.1\|15369_16209_-	sulfonamide-resistant dihydropteroate synthase Sul1	A0A0B5J4J5	Pandoravirus	5.0e-11	27.2
AZB79796.1\|16202_16550_-	quaternary ammonium compound efflux SMR transporter QacE delta 1	NA	NA	NA	NA
AZB79797.1\|16713_17505_-	ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA2	NA	NA	NA	NA
AZB79798.1\|17510_17801_-	DUF1010 domain-containing protein	NA	NA	NA	NA
AZB79799.1\|17912_18410_-	trimethoprim-resistant dihydrofolate reductase DfrA12	A0A0A0PL85	Bacillus_phage	7.5e-23	40.9
AZB79800.1\|23911_24103_+	prephenate dehydratase	NA	NA	NA	NA
AZB79801.1\|24225_25140_+	metal ABC transporter substrate-binding protein	NA	NA	NA	NA
AZB79802.1\|25139_25967_+	manganese/iron ABC transporter ATP-binding protein	A0A1M7XV31	Cedratvirus	3.6e-14	27.0
AZB79803.1\|25963_26821_+	metal ABC transporter permease	NA	NA	NA	NA
AZB79804.1\|28573_28846_+	hypothetical protein	NA	NA	NA	NA
AZB79805.1\|28917_29298_+	fluoride efflux transporter CrcB	A0A2H4J148	uncultured_Caudovirales_phage	1.9e-26	55.0
AZB79806.1\|29677_30871_-	MFS transporter	NA	NA	NA	NA
AZB79807.1\|31006_32731_+	IucA/IucC family siderophore biosynthesis protein	NA	NA	NA	NA
AZB79808.1\|32731_33679_+	N-acetyltransferase	NA	NA	NA	NA
AZB79809.1\|33678_35421_+	IucA/IucC family siderophore biosynthesis protein	NA	NA	NA	NA
AZB79810.1\|35417_36695_+	L-lysine N6-monooxygenase	NA	NA	NA	NA
AZB79811.1\|36776_38978_+	TonB-dependent receptor	NA	NA	NA	NA
AZB79812.1\|40308_41331_-	DNA helicase UvrD	NA	NA	NA	NA
AZB79813.1\|41315_42881_-	ATP-dependent endonuclease	NA	NA	NA	NA
AZB79814.1\|42955_43372_-	PIN domain-containing protein	NA	NA	NA	NA
AZB79815.1\|43368_43599_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
AZB79816.1\|43949_47774_+	pcar	NA	NA	NA	NA
AZB79817.1\|47818_48235_-	PIN domain-containing protein	NA	NA	NA	NA
AZB79818.1\|48231_48462_-	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	NA	NA	NA	NA
AZB79819.1\|48726_49227_+	hypothetical protein	NA	NA	NA	NA
AZB79820.1\|49239_50013_+	hypothetical protein	NA	NA	NA	NA
AZB79821.1\|50179_51313_+	hypothetical protein	NA	NA	NA	NA
AZB79822.1\|51346_51859_-	hypothetical protein	NA	NA	NA	NA
AZB79823.1\|52425_52644_+	antitoxin CcdA	NA	NA	NA	NA
AZB79824.1\|52645_52951_+	toxin CcdB	NA	NA	NA	NA
AZB79825.1\|52951_53758_+\|integrase	phage integrase family protein	I3WFA4	Macacine_betaherpesvirus	5.8e-57	100.0

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

3. CP033946

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CRISPR-Cas detection and classification

Crispr_ID: CP033946_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP033946_1

1656893-1657041

Orphan

Consensus_repeat	Method
GGGTGTCATACCCCGATTAGTTCGCCATCCCGTAGGCCTGATAAGCG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP033946_1

>merge|CP033946|1|1656893-1657041|CRISPRCasFinder
GGGTGTCATACCCCGATTAGTTCGCCATCCCGTAGGCCTGATAAGCGCACCGCCATCAGGCAGTGTGGCGGCTACGCCTGACCCGGTCTGGATTATACGGTGGGGTGTCATACCCCGATTAGTTCGCCATCCCGTAGGCCTGATAAGCG

>CP033946|1|1|1656893-1657041|CRISPRCasFinder
GGGTGTCATACCCCGATTAGTTCGCCATCCCGTAGGCCTGATAAGCG	CACCGCCATCAGGCAGTGTGGCGGCTACGCCTGACCCGGTCTGGATTATACGGTG
GGGTGTCATACCCCGATTAGTTCGCCATCCCGTAGGCCTGATAAGCG

Protein	Signature genes	Signature genes Name	Protein_function
CP033946.1\|AZB76112.1\|1659465_1660362_+\|GalU-regulator-GalF	unknown	unknown	gnl\|CDD\|182252
CP033946.1\|AZB76107.1\|1652531_1653380_+\|DNA-3-methyladenine-glycosylase-2	unknown	unknown	gnl\|CDD\|236671
CP033946.1\|AZB76118.1\|1667747_1669163_+\|undecaprenyl-phosphate-galactose-phosphotransferase-WbaP	unknown	unknown	gnl\|CDD\|185126
CP033946.1\|AZB76108.1\|1653494_1654136_+\|uridine-kinase	unknown	unknown	gnl\|CDD\|235492
CP033946.1\|AZB79432.1\|1648895_1650752_-\|histidine-kinase	unknown	unknown	gnl\|CDD\|223715
CP033946.1\|AZB76113.1\|1660754_1661384_+\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|214471
CP033946.1\|AZB76110.1\|1654838_1656686_+\|outer-membrane-assembly-protein-AsmA	unknown	unknown	gnl\|CDD\|236772
CP033946.1\|AZB79433.1\|1651041_1652394_-\|molecular-chaperone	unknown	unknown	gnl\|CDD\|236954
CP033946.1\|AZB76111.1\|1657122_1658706_-\|TerC-family-protein	unknown	unknown	gnl\|CDD\|223930
CP033946.1\|AZB76104.1\|1645526_1646801_+\|dicarboxylate/amino-acid:cation-symporter	unknown	unknown	gnl\|CDD\|224220
CP033946.1\|AZB76103.1\|1643987_1645226_-\|MdtA/MuxA-family-multidrug-efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl\|CDD\|183194
CP033946.1\|AZB76105.1\|1647074_1647686_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|197715
CP033946.1\|AZB76117.1\|1665511_1667674_+\|polysaccharide-biosynthesis-tyrosine-autokinase	unknown	unknown	gnl\|CDD\|183173
CP033946.1\|AZB76119.1\|1669162_1670290_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340839
CP033946.1\|AZB76106.1\|1648179_1648881_-\|DNA-binding-response-regulator	unknown	unknown	gnl\|CDD\|223816
CP033946.1\|AZB76120.1\|1670276_1671365_+\|hypothetical-protein	unknown	unknown	unknown
CP033946.1\|AZB76114.1\|1662343_1663777_+\|capsule-assembly-Wzi-family-protein	unknown	unknown	gnl\|CDD\|379441
CP033946.1\|AZB76109.1\|1654226_1654808_+\|dCTP-deaminase	unknown	unknown	gnl\|CDD\|274062
CP033946.1\|AZB76116.1\|1665061_1665496_+\|protein-tyrosine-phosphatase	unknown	unknown	gnl\|CDD\|182256
CP033946.1\|AZB76115.1\|1663922_1665059_+\|polysaccharide-export-protein	unknown	unknown	gnl\|CDD\|237903

Protein	Function_ID	Function_description	E-value
CP033946.1\|AZB76112.1\|1659465_1660362_+\|GalU-regulator-GalF	gnl\|CDD\|182252	PRK10122, PRK10122, UTP--glucose-1-phosphate uridylyltransferase GalF.	0
CP033946.1\|AZB76107.1\|1652531_1653380_+\|DNA-3-methyladenine-glycosylase-2	gnl\|CDD\|236671	PRK10308, PRK10308, 3-methyl-adenine DNA glycosylase II; Provisional.	2.48568e-180
CP033946.1\|AZB76118.1\|1667747_1669163_+\|undecaprenyl-phosphate-galactose-phosphotransferase-WbaP	gnl\|CDD\|185126	PRK15204, PRK15204, undecaprenyl-phosphate galactose phosphotransferase; Provisional.	0
CP033946.1\|AZB76108.1\|1653494_1654136_+\|uridine-kinase	gnl\|CDD\|235492	PRK05480, PRK05480, uridine/cytidine kinase; Provisional.	1.7406e-147
CP033946.1\|AZB79432.1\|1648895_1650752_-\|histidine-kinase	gnl\|CDD\|223715	COG0642, BaeS, Signal transduction histidine kinase [Signal transduction mechanisms].	5.20803e-41
CP033946.1\|AZB76113.1\|1660754_1661384_+\|phosphatase-PAP2-family-protein	gnl\|CDD\|214471	smart00014, acidPPc, Acid phosphatase homologues.	2.01033e-16
CP033946.1\|AZB76110.1\|1654838_1656686_+\|outer-membrane-assembly-protein-AsmA	gnl\|CDD\|236772	PRK10833, PRK10833, putative assembly protein; Provisional.	0
CP033946.1\|AZB79433.1\|1651041_1652394_-\|molecular-chaperone	gnl\|CDD\|236954	PRK11678, PRK11678, putative chaperone; Provisional.	0
CP033946.1\|AZB76111.1\|1657122_1658706_-\|TerC-family-protein	gnl\|CDD\|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	1.16012e-98
CP033946.1\|AZB76104.1\|1645526_1646801_+\|dicarboxylate/amino-acid:cation-symporter	gnl\|CDD\|224220	COG1301, GltP, Na+/H+-dicarboxylate symporters [Energy production and conversion].	5.66596e-108
CP033946.1\|AZB76103.1\|1643987_1645226_-\|MdtA/MuxA-family-multidrug-efflux-RND-transporter-periplasmic-adaptor-subunit	gnl\|CDD\|183194	PRK11556, PRK11556, MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit.	0
CP033946.1\|AZB76105.1\|1647074_1647686_-\|DNA-binding-response-regulator	gnl\|CDD\|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	0.00205647
CP033946.1\|AZB76117.1\|1665511_1667674_+\|polysaccharide-biosynthesis-tyrosine-autokinase	gnl\|CDD\|183173	PRK11519, PRK11519, tyrosine-protein kinase Wzc.	0
CP033946.1\|AZB76119.1\|1669162_1670290_+\|glycosyltransferase	gnl\|CDD\|340839	cd03811, GT4_GT28_WabH-like, family 4 and family 28 glycosyltransferases similar to Klebsiella WabH. This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.	5.39954e-35
CP033946.1\|AZB76106.1\|1648179_1648881_-\|DNA-binding-response-regulator	gnl\|CDD\|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	9.58437e-37
CP033946.1\|AZB76114.1\|1662343_1663777_+\|capsule-assembly-Wzi-family-protein	gnl\|CDD\|379441	pfam14052, Caps_assemb_Wzi, Capsule assembly protein Wzi. Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation. This family plays a role in group 1 capsule biosynthesis. It is likely to be involved in the later stages of capsule assembly. It is likely to consist of a beta-barrel structure.	1.26207e-135
CP033946.1\|AZB76109.1\|1654226_1654808_+\|dCTP-deaminase	gnl\|CDD\|274062	TIGR02274, Probable_deoxycytidine_triphosphate_deaminase, deoxycytidine triphosphate deaminase. Members of this family include the Escherichia coli monofunctional deoxycytidine triphosphate deaminase (dCTP deaminase) and a Methanocaldococcus jannaschii bifunctional dCTP deaminase (3.5.4.13)/dUTP diphosphatase (EC 3.6.1.23), which has the EC number 3.5.4.30 for the overall operation. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism].	1.60713e-93
CP033946.1\|AZB76116.1\|1665061_1665496_+\|protein-tyrosine-phosphatase	gnl\|CDD\|182256	PRK10126, PRK10126, low molecular weight protein-tyrosine-phosphatase Wzb.	5.57175e-61
CP033946.1\|AZB76115.1\|1663922_1665059_+\|polysaccharide-export-protein	gnl\|CDD\|237903	PRK15078, PRK15078, polysaccharide export protein Wza; Provisional.	0

>CP033946.1|AZB76110.1|1654838_1656686_+|outer-membrane-assembly-protein-AsmA
MRRILTTLMILLAVIVAGLTSLVLLVNPNDFRAYMVHEVAERSGYQLDLDGPLRWHVWPQLSILSGRMTLTARGAEEPVIRADNMRLDVALLPLLSHQLQVKQVMLKGAVIQLTPKTEAVRDSSAPVVPHDNTLPLAPEDRGWSYDVRQLQVADSVLFFQHENGEQVTVRDIRLQMEQDENHRATVDFSGRVNRDQRDLALSFSATVQGGDYPHSLKADFTQLSWQLRGAELPPDGINGQGSLQASWQEDDKTLRFDNLNLMANRSTVTGSGSVVLGERPDWSLDLHATTLDLDSLLAQRPPATDSSASQQGQSQTRPLRPVIADSNEREDYQSLRGFNGRMALSADQLQWRGLNFTQVQSEISNQQGLLTVSKMQGKLDGGQLSLPGTLDARGDTPLATFQPALQNVEIGSLIKAFNYSLNLTGKLSLSGEFSGTRIDADDFRRHWQGQAQLQMADTRTEGLNFQQLVQQAVERSNNVRAQENYDNATRLDSVSSRLTLDNGLVTLNRLQGQSDVMAMTGEGQLDLQKENCDMRFNVRVLGGWKGEGKLIDRLKQTAIPLRIYGEWQSLSYSLQVDQILRKQLQDEAKQRLNDWVERNKGSKDGNDAKKLLDKL
>CP033946.1|AZB76109.1|1654226_1654808_+|dCTP-deaminase
MRLCDRDIEAWLDEGRLAINPRPPVERINGATVDVRLGNKFRTFRGHTAPFIDLSGPKAEVSAALDRVMSEEIVLPEGEAFFLHPGELALAVTYESVTLPADLVGWLDGRSSLARLGLMVHVTAHRIDPGWSGCIVLEFYNSGKLPLALRPGMPIGALSFEPLSGPAARPYNRREDAKYRDQQGAVASRIDKD
>CP033946.1|AZB76108.1|1653494_1654136_+|uridine-kinase
MTDMSHQCVIVGIAGASASGKSLIASTLYRELREQVGDEHIGVIPEDSYYKDQSHLSMEERVKTNYDHPSSMDHSLLFQHLQMLKSGQPIELPVYSYVEHTRTPNTIHVEPKKVIILEGILLLTDARLRNELNFSIFVDTPLDICLMRRIKRDVNERGRSMDSVMAQYQKTVRPMFLQFIEPSKQYADIIVPRGGKNRIAIDILKAKISQFFE
>CP033946.1|AZB76107.1|1652531_1653380_+|DNA-3-methyladenine-glycosylase-2
MVLLPWTPPYDWAWMVGFLQARAVAGVERFHDGGYSRSFGVEGHRGLIHLAPDEEAQGLRVTLSPGLQPVAEICYARIGQLFDLACDPRQVARTLGDLAQARPGLRLPGALDAFEQAVRAVLGQLVSVAMAARLTAKVAAGWGEPLAESPGYVLFPTPEALSRADPQALKALGMPLRRAEALIHLARAALSGELPLTAPADIDAGLRQLQTLPGIGRWTANYFALRGWQAKDIFLPDDYLIKQRFPGMTPAAIARYARRWQPMRSYALLHIWYTDDWAPAAE
>CP033946.1|AZB79433.1|1651041_1652394_-|molecular-chaperone
MFIGFDYGTANCSVAVMRENTPQLLTLENGSALLPSMLCAPTREAVSEWLYRHHDVPTHSDENQALLRRAIAANRDEDIEVLRNSVQFGLASLQQYVEDPEEVYFVKSPKSFLGASGLKPQQVALFEDLVCAMMLHIKLQAESQLPEQIDQAVIGRPINFQGLGGDEANAQAQGILERAAHRAGFRDVVFQFEPVAAGLDFEATLSEEKRVLVVDIGGGTTDCSLLLMGPQWRERADRQQSLLGHSGCRIGGNDLDIALAFKCLMPLLGMGGETEKGTALPILPWWNAVAINDVPAQSDFYSTANGRLLNDLLRSARDADKVALLLKVWRQRLSYRLVRSAEESKIALSSAASVETALPFIQDELATAIAQQGLEAALDQPLTRIMEQVRLALDSSQTTPDVIYLTGGSARSPLIKKALAAQLPGIPLAGGDDFGSVTAGLARWAQVVFR
>CP033946.1|AZB79432.1|1648895_1650752_-|histidine-kinase
MLLVAPQAQAATRQVGIDIPVQWYADDSGQMTLDRFAALPADQLATTRQIPSFGYSRKTWWLRSELPGTWFAGEPRWLQLGPTFVDHLTIYYRPLGSDGPWTQRIFGDRDGARGSDLHYRERVLILPPPPTAAGYELVFRLQSTSTLILLASLSSAQAFVQRATADTAFWSFYFGLAAVASGVALWLALALRRRLLWGICLFSLNYPLVAALHGFPEWFFGHAALPFQDFMISSLSLFSYATALWLHSEIFDLKKNMPRLHQLLIAAVILNLVLQVSIPLGFYGFAMQIEGVVFIIITPVLLFTSWWLWRKKAIDRTTLLLGLLPPFYVVAAVLVQLSIHGIIPFHMAIYSLWQYALIVHIITVLIIAILRVRAENRQLEQKQRLARELQIEREASFHQRQFMGMVAHEFRTPLAVIQAALENLRLSAASTSQEARFDRIGRAATRLVQLTDNCLADARLASHDLHVERQQTALLTVINMAASVVAISHDHYLNIRQHGAVESPQLQADAGLLCIAIANLLDNAVKYSPPGEIAIDIHSDAGQTELRIRDHGPGLPAGQAELIFERYRRGEHTSPVPGGTGLGLYVARQIVQAHDGKLWLAEHGPDGCTFILTLPTVA
>CP033946.1|AZB76106.1|1648179_1648881_-|DNA-binding-response-regulator
MALRLAIIEDNADLLDELLAWLGYRGFEVWGTRSAEAFWRQLHSHPVDIVLVDIGLPGEDGFSVLNYLHELGHYGLVVVSARGQQQDKLQALSLGADAYLIKPVNFAHLAETLTALGARLRQDRPAAPTAEAIGTPPAVSPGSWRLHEDKLISPDARTLELTQQEYRLVELLMRNRNEVCSKLDLHACLFSHESEPDLHRIDVVVSRLRHKARQQGIHLPVRAIFGKGLAFIS
>CP033946.1|AZB76105.1|1647074_1647686_-|DNA-binding-response-regulator
MRNINVTINTRNAFVRESLVAMVNDLTRGDLRARFSWRNTDLSAEDIIICEVIPGEIYLCNTLIKNRKRGSSLIILHSYDQLPEDEFMINCLKGVIFVSLKTASIPQLLTIIKSELQHCMAPTATDAAGRELSCASCPHRVLSRSQTAVVHGILEGLDMSKIAALQRVSPRTAAYHKNKIMEKYSLNNNHEFFQFMNLLRERW
>CP033946.1|AZB76104.1|1645526_1646801_+|dicarboxylate/amino-acid:cation-symporter
MANANKLTLFIVVFMLMGILSGAAIHAYATPTTVSAWADNITLLTDLFLRLIKMVIAPLVFSTLTVGIMRLGETATIGRVGGKAMVWFITSSVLSILVGLVIVTFQHPGAGLNLAVPKEAVDTGLAVSGMSLKGFLSHTIPTSITEAMANNEILQIVVFSMFFGIAGASLGEKFNAPLVAALNVVSHIMLKVTGYVMYVAPLAIFAAISSVIASQGLGILLNYASFIGGYYLAVLLTSAVLIAVGYMVLKKEVFRLLNMLKDPVLVAFTTSSSEAAYPKTLERLVKFGCSRNIVSFVLPIGYSFNLVGSMVYCSFAAMFIAQAYNVPLSFSEITVMMLTLMLASKGIAGVPRSALVVLAATIPSFNIPVAGILLLMGIDHFLDMGRSAINVLGNGIATAMLSKNEGLLTDEEAQPDWEVEKAKA
>CP033946.1|AZB76103.1|1643987_1645226_-|MdtA/MuxA-family-multidrug-efflux-RND-transporter-periplasmic-adaptor-subunit
MKGSNIRRWGAALAVVIIAGAAYWFWHDSGTSGSGAPAAGQGPQGPGGARHGRFGAALAPVQAATATEEAVPRYLTGLGTVTAANTVTVRSRVDGQLLSLHFQEGQQVKAGDLLAQIDPSQFKVALAQAQGQLAKDQATLANARRDLARYQQLVKTNLVSRQELDTQQSLVVESAGTVKADEAAVASAQLQLDWTRITAPIDGRVGLKQVDIGNQISSGDTTGIVVLTQTHPIDVVFTLPENSIATVVQAQKAGKALSVEAWDRTNKQKISVGELLSLDNQIDATTGTIKLKARFSNLDDALFPNQFVNARLLVDTQQNAVVIPAAALQMGNEGHFVWVLNDENKVSKHSVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEVVTASSREQAQPAPRQSGKHGARS
>CP033946.1|AZB76111.1|1657122_1658706_-|TerC-family-protein
MEWIADPSIWAGLVTLVVIELVLGIDNLVFIAILAEKLPPAQRDRARITGLMLAMVMRLLLLASISWLVTLTKPLIVFHDFSFSARDLIMLFGGLFLLFKATVELNERLEGKDSDNPTQRKGAKFWAVVAQIVVLDAIFSLDSVITAVGMVDHLAVMMAAVVIAISLMLMASKALTRFVNSHPTIVILCLSFLLMIGFSLIAEGFSFIIPKGYLYAAIGFSVMIEALNQLAQFNRRRFLSANMTLRQRTTEAVMNLLSGQKEKAELDADTASLVADQDQHPLFNPQERLMIERVLNLNQRSVSSIMTSRHDIERINLSAPEEEIRSLVEKNQHTRLVITGGKDNEDLLGVVHVIDLLQQSLRQEPLDLQALVRQPLVFPEGLPLLSALEQFRQARTHFAFVVDEFGSVEGIVTLSDVMETIAGNLPNEVEEIDARHDIQHHQDGSWTVNGHMPLEDLVQYVPLPLDDKREYHTVAGLLMEYLQHVPQVGETIEIDGYTLRTLQVDSHRVQKVQIVPPVKQDELDYEV
>CP033946.1|AZB76112.1|1659465_1660362_+|GalU-regulator-GalF
MNMANLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDEIVAAGIKEIVLVTHSSKNAVENHFDTSYELEALLEQRVKRQLLAEVQAICPPGVTIMNVRQAQPLGLGHSILCARPVVGDNPFVVVLPDIILDGGTADPLRYNLAAMIARFNETGRSQVLAKRMPGDLSEYSVIQTKEPMVAEGQVARIVEFIEKPDEPQTLDSDLMAVGRYVLSADIWAELERTEPGAWGRIQLTDAIAELAKKQSVDAMLMTGESYDCGKKMGYMQAFVTYGMRNLKEGTKFRESIKKMLA
>CP033946.1|AZB76113.1|1660754_1661384_+|phosphatase-PAP2-family-protein
MNWQLISFFGDSTVLLPSAAALFIVLMLRKTSRLLAWQWSLLFGITGAIVCASKLAFMGWGLGIRELDYTGFSGHSALSAAFWPIFLWLLSARFSVGLRKAAVITGYVLAAVVGYSRLVIHAHSVSEVIAGLLLGAAGSALFLVLQKRTSDPESVNISWGGVACLVMVPLILLHSGSKAPTQSLLGQIATAVGPLDKPFTRTDLHKQAW
>CP033946.1|AZB76114.1|1662343_1663777_+|capsule-assembly-Wzi-family-protein
MIKIARIAVTLGLLSSLGAQAYAAGLVVNDNDLRNDLAWLSDRGVIHLSLSTWPLSQEEIARALKKAKPSYSSEQVVLARINQRLSALKADFRVTGYTSTDQPGTPQGFGQTQPADNSLGLAFNNSGEWWDVHLQGNVEGGERISNGSRFNANGAYGAVKFWNQWLSFGQIPQWWGPGYEGSLIRGDAMRPMTGFLMQRAEQAAPETWWLRWVGPWQYQISASQMNQYTAVPHAKIIGGRFTFSPFQSLELGASRIMQWGGEGRPESFSSFWDGFTGHDNTGTDNEPGNQLAGFDFKFKLEPTLGWPVSFYGQMVGEDESGYLPSANMFLGGVEGHHGWGKDAVNWYVEAHDTRTNMSRTNYSYTHHIYKDGYYQQGYPLGDAMGGDGQLIAGKVELITEDNQRWSTRLVYAKVNPENQSINKAFPHADTLKGVQLGWSGDVYQSVRLNTSLWYTNANNSDSDDVGASAGIEIPFSL
>CP033946.1|AZB76115.1|1663922_1665059_+|polysaccharide-export-protein
MKKKLVRFSALALAIGFLSGCTIIPGQGLNSLRKNVVELPDSDYDLDKLVNVYPMTPGLIDQLRPETVLARPNPQLDNLLRSYEYRIGVGDVLMVTVWDHPELTTPAGQYRSASDTGNWVNSDGTIFYPYIGKVQVAGKTLAQVRQDIASRLTTYIESPQVDVSVAAFRSQKAYVTGEVTKSGQQPITNIPLTVMDAINAAGGLAPDADWRNVVLTHNGKDTKVSLYALMQKGDLTQNHLLYPGDILFVPRNDDLKVFVMGEVGKQSTMKMDRSGMTLAEALGNAEGMSQAFSDATGVFVIRQIKNDSQGKIANIYQLNAQDASAMVLGTEFQLQPYDIVYVTTAPLVRWNRVISQLVPTISGVHDMTETTRYIKDWP
>CP033946.1|AZB76116.1|1665061_1665496_+|protein-tyrosine-phosphatase
MFKSILVICTGNICRSPFGEHVLHRLLPTLKIDSAGVSALVNHEADPTAVKIASKFGISLEGHKGKQFTPLMGRDYDLLLVMDKAHLEQVCKISPEVRGKTMLLGHWLGSREIADPYRKSDEAFELIFELIEQSCSLWAKKLTS
>CP033946.1|AZB76117.1|1665511_1667674_+|polysaccharide-biosynthesis-tyrosine-autokinase
MTLSQNNKISQQENDIIDLGRLFGEIIDHRKLILSITAAVTLLAILYVSLSTPIYQANALVQVEQKQGNAILNGLSQILPSTQPQSAPEITLLQSRMILGKTVDDMDLQYSVKPKSIPFIGEGIDRIWGEGKGEIHIKHLYIPMRNGENVASFVLTVKNKSTYEIKKDDVEAEGNVGTTLEVGGISLLVDAITAREGSQFVVNYKTRLKAISDLQDALSISEQGKDTGMLELTLIGANPTLIRNTLDGITQNYLEQNVARQAAQDAKSLDFLNKQLPKVRDELDIAESKLNTYRKQKDSVDLSMEAKTVLDQIVNVDNQLNELTFREAEISQLYTKEHPTYKALMEKKQTLQEEKSKLGKRVSSMPATQQEVLRLSRDVESGRAVYLQLLNRQQELNIAKSSAIGNVRVIDNAVTDPEPVKPKKVLIIVGAVIIGLILSIILVLLKVFLRRGIESPEQLEELGINVYASIPVSEWLTNKTSKTNKKKNESEILLIDENPADLAVEAIRSLRTSLHFAMMESKNNVLMISGASPNAGKTFVSTNLAATIASAGKRVLFIDADLRKGYVHKIFKNNHEKGLSDILSGLIEVKSSIEKVPNGAFDFISRGQVPPNPSELLMHPRFEALLKWASQEYDLVIIDTPPILAVTDAAIIGRYVGTTLLVARYEANTAKEILISKRRFEQSGVEIKGCILNGVVKKASSYYGYGYNHYGYSYGEHPKK
>CP033946.1|AZB76118.1|1667747_1669163_+|undecaprenyl-phosphate-galactose-phosphotransferase-WbaP
MTHYIRNVGCSFFLAIADFISFVLSLYISLQLLSFSYLYVPTEQIEGWISLHWVLGVLCVGWYGIRLRHYFYRKTFWFELKEIIRTLLIFAVIEMAIMAFAKWDFYRYAFFLTWLIAILLVPIFRIVTKWFLNKIGLWARNAWIIGSGKNAIDAFKAIQSEHNLGLNIIGYVDECDIENDYFKSLHLKHYKFDSFPIDSIPKTTQFIVAVESEQSEIRNSWLRTFMMKGFRYVSIIPTLRGVPLDSTDMSFIFSHDVMIFRVHNNLAKISSRILKRIFDIVGASIIIIILSPLLIYISLKVKKDGGPAIYGHKRVGKRGVPFNCLKFRSMVTNSKEVLENLLLNDPASKMEWDATFKLKNDPRVTKIGAFLRRTSLDELPQLFNVLKGEMSLVGPRPIIDEELERYNDEVEYYLLSKPGMTGLWQVSGRSDVDYETRVYLDTWYVKNWSMWNDLVILFKTVNVVLRRDGAY
>CP033946.1|AZB76119.1|1669162_1670290_+|glycosyltransferase
MDQQNVNNFDSNRIKIVYVINTLDPGGAELGLEKLIKNNLFNEFDLNLIVIQKTNSALYSRLNDNLANKISYLTESKIKNIFIPLYAVKLSKLLQKIRPDIVISSLSQSTIITRLLKVLFNYKHISFEHNTNFQNKLAYQIISKTDSLSDYFWCDSIATQKFLLERGVEKIKSKIIPLFYIDHAITFLEKTFSPELKIISVGRLTKQKNYAYTLSVLKKLVDKGVNASLDIYGVGELKEELIILSNELMIANRVNFKGFVSDWKEDAKNADIYMLSSDFEGLSIATLEAMSIGMLCVVRPTGEVKNYLTNNSTGIIASNEDEACDKIMTILNDNSLYNSIRCNAYNFVWDNFSINEYLNAISEAKLELEALYDNT
>CP033946.1|AZB76120.1|1670276_1671365_+|hypothetical-protein
MIIPKLAMKGGKEKILLLDQGQSLIIWFILFFTMMIFSLYKEDIFPIYYFWDANTISSLLNSAKFIYADSYQSTAAFFSIFGVTRESYWFSLFSTGIIIFYYIIALRKSNVDIIYLKEYLVLIYCMLLSVVYMTLLSKDFIVLLIIFPFISFSRTNRGLLLWSFIALVYAYFFRTYWILIVSLFWGIYLVLPFLRKGYSLFLIIIMALLVISFLFNNIMGVEVDSFRRSVNELRLDGNVENAKTMILPFFDSGGVFWGWINVVLTWITMMLPLPLFLTFSPLYLILFLLITMLWSLFWKSVSKSFMSKDKTLRAVIALILSFSALQSIFEPDYGSYVRHLSPLYPLFFYIYFLSKKYVGINK

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Crispr_ID: CP033946_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP033946_2

2351206-2351330

Orphan

Consensus_repeat	Method
CGACCCCCACCATGTCAAGGTGGTGCTCTAACCAACTGAGCTAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP033946_2

>merge|CP033946|2|2351206-2351330|CRISPRCasFinder
CGACCCCCACCATGTCAAGGTGGTGCTCTAACCAACTGAGCTACAGACGCATTATGGTGCGTTTAATTGGACTCGAACCAACGACCCCCACCATGTCAAGGTGGTGCTCTAACCAACTGAGCTAC

>CP033946|2|2|2351206-2351330|CRISPRCasFinder
CGACCCCCACCATGTCAAGGTGGTGCTCTAACCAACTGAGCTAC	AGACGCATTATGGTGCGTTTAATTGGACTCGAACCAA
CGACCCCCACCATGTCAAGGTGGTGCTCTAACCAACTGAGCTAC

Protein	Signature genes	Signature genes Name	Protein_function
CP033946.1\|AZB79469.1\|2360040_2360130_+\|YnhF-family-membrane-protein	unknown	unknown	gnl\|CDD\|341227
CP033946.1\|AZB76736.1\|2350380_2350563_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274528
CP033946.1\|AZB76743.1\|2356494_2357676_-\|Bcr/CflA-family-multidrug-efflux-MFS-transporter	unknown	unknown	gnl\|CDD\|182924
CP033946.1\|AZB76745.1\|2358719_2359745_-\|PurR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|236739
CP033946.1\|AZB76746.1\|2360297_2361464_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|225371
CP033946.1\|AZB76737.1\|2350764_2350992_+\|hypothetical-protein	unknown	unknown	unknown
CP033946.1\|AZB76729.1\|2344305_2344941_+\|carbonic-anhydrase	unknown	unknown	gnl\|CDD\|238449
CP033946.1\|AZB76731.1\|2345547_2346264_-\|hypothetical-protein	unknown	unknown	unknown
CP033946.1\|AZB76741.1\|2354381_2355017_+\|riboflavin-synthase	unknown	unknown	gnl\|CDD\|183846
CP033946.1\|AZB76732.1\|2346309_2346744_-\|winged-helix-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|366125
CP033946.1\|AZB76739.1\|2352309_2352603_-\|acid-resistance-repetitive-basic-protein-Asr	unknown	unknown	gnl\|CDD\|237855
CP033946.1\|AZB76742.1\|2355053_2356202_-\|cyclopropane-fatty-acyl-phospholipid-synthase	unknown	unknown	gnl\|CDD\|183282
CP033946.1\|AZB76738.1\|2351590_2352169_+\|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl\|CDD\|129813
CP033946.1\|AZB76730.1\|2345253_2345463_-\|DUF1471-domain-containing-protein	unknown	unknown	gnl\|CDD\|369322
CP033946.1\|AZB76740.1\|2352778_2354152_-\|MdtK-family-multidrug-efflux-MATE-transporter	unknown	unknown	gnl\|CDD\|234981
CP033946.1\|AZB79468.1\|2350516_2350768_+\|hypothetical-protein	unknown	unknown	unknown
CP033946.1\|AZB76735.1\|2348898_2349783_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182990
CP033946.1\|AZB76734.1\|2348226_2348742_-\|hypothetical-protein	unknown	unknown	unknown
CP033946.1\|AZB76744.1\|2357788_2358793_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182948
CP033946.1\|AZB76733.1\|2347382_2348219_-\|MBL-fold-metallo-hydrolase	unknown	unknown	gnl\|CDD\|293806

Protein	Function_ID	Function_description	E-value
CP033946.1\|AZB76736.1\|2350380_2350563_+\|hypothetical-protein	gnl\|CDD\|274528	TIGR03345, VI_ClpV1, type VI secretion ATPase, ClpV1 family. Members of this protein family are homologs of ClpB, an ATPase associated with chaperone-related functions. These ClpB homologs, designated ClpV1, are a key component of the bacterial pathogenicity-associated type VI secretion system. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis].	0.00650477
CP033946.1\|AZB76743.1\|2356494_2357676_-\|Bcr/CflA-family-multidrug-efflux-MFS-transporter	gnl\|CDD\|182924	PRK11043, PRK11043, Bcr/CflA family multidrug efflux MFS transporter.	0
CP033946.1\|AZB76745.1\|2358719_2359745_-\|PurR-family-transcriptional-regulator	gnl\|CDD\|236739	PRK10703, PRK10703, HTH-type transcriptional repressor PurR.	0
CP033946.1\|AZB76746.1\|2360297_2361464_+\|MFS-transporter	gnl\|CDD\|225371	COG2814, AraJ, Arabinose efflux permease [Carbohydrate transport and metabolism].	5.48458e-98
CP033946.1\|AZB76729.1\|2344305_2344941_+\|carbonic-anhydrase	gnl\|CDD\|238449	cd00884, beta_CA_cladeB, Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.	2.46323e-91
CP033946.1\|AZB76744.1\|2357788_2358793_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182948	PRK11074, PRK11074, putative DNA-binding transcriptional regulator; Provisional.	0
CP033946.1\|AZB76741.1\|2354381_2355017_+\|riboflavin-synthase	gnl\|CDD\|183846	PRK13020, PRK13020, riboflavin synthase subunit alpha; Provisional.	7.01007e-124
CP033946.1\|AZB76732.1\|2346309_2346744_-\|winged-helix-family-transcriptional-regulator	gnl\|CDD\|366125	pfam00486, Trans_reg_C, Transcriptional regulatory protein, C terminal.	0.00258176
CP033946.1\|AZB76739.1\|2352309_2352603_-\|acid-resistance-repetitive-basic-protein-Asr	gnl\|CDD\|237855	PRK14900, valS, valyl-tRNA synthetase; Provisional.	0.00619382
CP033946.1\|AZB76738.1\|2351590_2352169_+\|TIGR00730-family-Rossman-fold-protein	gnl\|CDD\|129813	TIGR00730, LOG_family_protein_YJL055W, TIGR00730 family protein. This model represents one branch of a subfamily of proteins of unknown function. Both PSI-BLAST and weak hits by this model show a low level of similarity to and suggest an evolutionary relationship of the subfamily to the DprA/Smf family of DNA-processing proteins involved in chromosomal transformation with foreign DNA. Both Aquifex aeolicus and Mycobacterium leprae have one member in each of two branches of this subfamily, suggesting that the branches may have distinct functions. [Hypothetical proteins, Conserved].	1.0517e-62
CP033946.1\|AZB76730.1\|2345253_2345463_-\|DUF1471-domain-containing-protein	gnl\|CDD\|369322	pfam07338, DUF1471, Protein of unknown function (DUF1471). This family consists of several hypothetical Enterobacterial proteins of around 90 residues in length. Some members of this family are annotated as ydgH precursors and contain two copies of this region, one at the N-terminus and the other at the C-terminus. The function of this family is unknown.	0.000322115
CP033946.1\|AZB76740.1\|2352778_2354152_-\|MdtK-family-multidrug-efflux-MATE-transporter	gnl\|CDD\|234981	PRK01766, PRK01766, multidrug efflux protein; Reviewed.	0
CP033946.1\|AZB79469.1\|2360040_2360130_+\|YnhF-family-membrane-protein	gnl\|CDD\|341227	PRK14756, small_mem_YnhF, YnhF family membrane protein; Validated.	0.00149942
CP033946.1\|AZB76735.1\|2348898_2349783_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	1.06847e-68
CP033946.1\|AZB76742.1\|2355053_2356202_-\|cyclopropane-fatty-acyl-phospholipid-synthase	gnl\|CDD\|183282	PRK11705, PRK11705, cyclopropane fatty acyl phospholipid synthase.	0
CP033946.1\|AZB76733.1\|2347382_2348219_-\|MBL-fold-metallo-hydrolase	gnl\|CDD\|293806	cd07720, OPHC2-like_MBL-fold, Pseudomonas pseudoalcaligenes organophosphorus hydrolase C2, and related proteins; MBL-fold metallo hydrolase domain. Pseudomonas pseudoalcaligenes OPHC2 is a thermostable organophosphorus hydrolase which a broad substrate activity spectrum: it hydrolyzes various phosphotriesters, esters, and a lactone. This subgroup also includes Pseudomonas oleovorans PoOPH which exhibits high lactonase and esterase activities, and latent PTE activity. However, double mutations His250Ile/Ile263Trp switch PoOPH into an efficient and thermostable PTE. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	3.15174e-99

>CP033946.1|AZB76737.1|2350764_2350992_+|hypothetical-protein
MNIKRTLLILLSRVIRGAGMGLGASGIALAGWFFFFSVNEYKFLWGLLSVVEFLVGYLIYRFAYAYIYDEWNDYH
>CP033946.1|AZB79468.1|2350516_2350768_+|hypothetical-protein
MFAGSLAGLLLSVGAETSRAIYTSRYLKRRNPVLHDKLQNLRDLDLLYFLVEDIVKPFETARMVGDKNSAEFNKICEYFFGGL
>CP033946.1|AZB76736.1|2350380_2350563_+|hypothetical-protein
MFTGGRNIDSLLNQQLLTHMAAGQKPQHLTRGGMRQRGTPQEECPHFCRKSCRIIIIRWS
>CP033946.1|AZB76735.1|2348898_2349783_+|LysR-family-transcriptional-regulator
MRRKIPSSAALLAFEAAARHGNFARAAAELALTEGAISRQIARLEALLDNKLFDRTGSRVRLNPAGARYARQVREILARLERDTHDVSGMPVDGRSLEIAVLPTFASRWLIPRLGRFAAQHPHIVVNIAARSDPFILPGSGFDAAIHFEHPAWTGMEVTFLFAEYLLPVCHAALLTDDDLPGLLNRLTRIHRRQNPDAWLHYARECGLALDNPAQGPRYDLHEMAIAAVLSQQGVALVPKMYVESELRAGTLAAPWPGSPTLAKRFCLIKPGGGEGEPALQMFERWLQTEIAAG
>CP033946.1|AZB76734.1|2348226_2348742_-|hypothetical-protein
MLYVVECAYTDPQSEAAWNTFYNQEKLPALVSVPGFYASQRFRALSEGCPCYLALHDIHDATVIDSDAYRRNGGGHFARWQSAIADWHRHLYLTNNTLREVAPDEVLLLGDTAEDLPVAAPILLQPGGLATEQTRYAAILPRDNLHHLATTAAVFIYQPITARLRNPAQRA
>CP033946.1|AZB76733.1|2347382_2348219_-|MBL-fold-metallo-hydrolase
MSPAPFYTLTAGDLTVTAVSDGLMSAPLSLLSGISREEAEHLQRHSGLASPETIAIGAYLIRGRGNTVLVDTGTGGANGVGGELIANLARLGVGPEEIDAILLTHAHPDHIGGLLSAAGTPAYPNATVFLPTRESAYWLATSTFDNASDRGRRNVLLVRRVLANCAAQISGVDDEEVIAGIRPCPLPGHTPGHTGYRLEAGDTSLLIWGDIVHFPSIQSARPEASVAFDVDPEQARRTREILLRQAASERWLIAGMHLGLPGFARVENTASGYCLRSV
>CP033946.1|AZB76732.1|2346309_2346744_-|winged-helix-family-transcriptional-regulator
MTKGYKLLGYKLADNIFYCLHHREIITLRGTRTQVQLRSTMACLLEYLLAHGRERLVSDEELMINVWEKNNLRPSAQRLWQVIQSLKSRLHQAGVESALIIRVKCAGYYINNVYVAEIYSYKPPGMMNYINTSPADMNKLLVRS
>CP033946.1|AZB76731.1|2345547_2346264_-|hypothetical-protein
MNILIHSNNIYFNIGIAQCFRDIQKTAPELKVIHSLPLSHLPELSGLDVIILSLENYHDYLAAAEIAQHFQGLVIGFTSAGNVRRGRPFFADTLLWVSQREAVREVSRLLRCLAERRWPLVPRHQRQSVSFRQRAPLNRLEMRMIDATMKGQSVHQMAATLGINRKRVYNGLERIKENFRLVSHSHFHHFMTDRLSFSRLSADLRCLTTAANATLPPRAASRLAENHSYYLKEFRKLF
>CP033946.1|AZB76730.1|2345253_2345463_-|DUF1471-domain-containing-protein
MKFIKTFVAVAALSLFSAASFAQSVSATASTLDRAEAKIAAQAAEQGASYKITSAQFNNRVHMTAELSK
>CP033946.1|AZB76729.1|2344305_2344941_+|carbonic-anhydrase
MQHIIEGFLNFQKEIFPQRKELFRSLASSQNPKALFISCSDSRLVPELVTQQEPGQLFVIRNAGNIVPSFGPEPGGVSATIEYAVVALGVTDIVICGHSNCGAMKAIATCQCLEPMPAVSHWLRYADAAKAVVEKKTWASETDKVNGMVQENVIAQLNNIKTHPSVAVGLRDHTLRLHGWFYDIETGDIQALDKNTKSFVSLSENPDVFFE
>CP033946.1|AZB76738.1|2351590_2352169_+|TIGR00730-family-Rossman-fold-protein
MKSIGIFCGSSAGEHPLYLETARLVGRTLAQQGLALVYGGGKVGLMGAVADAALEAGGVVIGVMPRGLVEREIAHRGLTELHVVEDMHERKTKMAALADGFIALPGGAGTLEEIFEQWTWAQLGIHEKPCAFLNIKGYYDPLQAMVDNMVREGFMHPRYAEMLPFATSADEIIAGFRDYTPPARKWVQQPAI
>CP033946.1|AZB76739.1|2352309_2352603_-|acid-resistance-repetitive-basic-protein-Asr
MKKVLALVVAAAMGLSSVAFAADAASTTPSAAASHTTVHHKKHHKAAAKPAAEQKAQAAKKHHKAAAKPAAEQKAQAAKKHHKTTHHAAKPAVKPAA
>CP033946.1|AZB76740.1|2352778_2354152_-|MdtK-family-multidrug-efflux-MATE-transporter
MQKYFVEARQLLALAIPVILAQVAQTAMGFVDTVMAGGYSATDMSAVAIGTSIWLPAILFGHGLLLALTPVVAQLNGSGRRERIAPQVRQGFWLAGFVSVLIMVVLWNAGYIISSMHNIDPLLAEKAVGYLRALLWGAPGYLFFQVARNQCEGLAKTKPGMVMGFIGLLVNIPVNYIFIYGHFGMPELGGVGCGVATASVYWVMFASMLWWVRRARTMRDIRCVERFSGPDFAVLLRLVQLGLPIALALFFEVTLFAVVALLVSPLGIIDVAGHQIALNFSSLMFVLPLSLAAAVTIRVGFRLGQGSTIDAQVSARTGVGVGVCLAVFTAIFTVLMRKQIALLYNDNPEVVTLASHLMLLAAIYQISDSIQVIGSGILRGYKDTRSIFFITFTAYWVLGLPSGYLLALTDMIVPRMGPAGFWCGFIIGLTSAAIMMMLRMRFLQRQPSSIILQRAAR
>CP033946.1|AZB76741.1|2354381_2355017_+|riboflavin-synthase
MFTGIVQGTAKVVSIDDKPNFRTHVVELPAHMLEGLETGASVANNGCCLTVTEINGAHISFDLMKETLRITNLGDIQVGDEVNVERAAKFSDEIGGHLMSGHIMTTAEIVKILTSENNRQIWFKVQDPTLMKYILYKGFIGIDGISLTVGEVTATRFCVHLIPETLQRTTLGAKKLGDRVNIEIDPQTQAVVDTVERVLAAKEMAAKVNEA
>CP033946.1|AZB76742.1|2355053_2356202_-|cyclopropane-fatty-acyl-phospholipid-synthase
MSSSCIEEVSVPNDDWYRIAAELLGRAGIEINGSAPSDLRVKNPLFFKRVLQEGSLGLGESYMDGWWECERLDIFFHKVLRAGLEKQLPHHFKDTLRIAGARLFNLQSKKRAWIVGKEHYDLGNDLFSRMLDPYMQYSCGYWKEAQSLEAAQQAKLDLICRKLELEPGMRVLDIGCGWGGLAEYMARNYQVSVVGVTISAEQQKMAQARCADLDVEIRLQDYRDLHDSFDRIVSVGMFEHVGPKNYATYFEVADRNLKPNGRFLLHTIGSKVTDHNVDPWIDKYIFPNGCLPSVRHIAEASEKHFVMEDWHNFGADYDTTLMAWYERFLASWPEIADNYSERFKRMFTYYLNACAGAFRARDIQLWQVVFSRGIEHGLRVAR
>CP033946.1|AZB76743.1|2356494_2357676_-|Bcr/CflA-family-multidrug-efflux-MFS-transporter
MSQPGKGFLVWLAGLSVLGFLATDMYLPAFAAMQQDLNTSAASISASLSLFLAGFALGQLFWGPLSDRYGRKPVLLSGLAIFAAGCLGMLWVHNATLMLALRFLQAIGVCAAAVTWQAMVADYYPAQRTNRIFATIMPLVGLSPALAPLLGSWLLVHFEWQAIFATLFAITLLLMLPALRLKAAAKSVVVTQQKITFLALLRSREYSGNVLIYAACSASFFAWLTGSPFILHEMGYGPTAIGLSYIPQTIAFLVGGYGCRALLQKWSGQQMLPWLLVIFAVSVAATWLVGLQTHASLVALMIPFCMMAVVNGGIYPIVVAQALKPFPQATGRAAALQNTLQLGLCFLTSLLVSALIATPLLTTTSVMLVSIGLAGIGYRLQQTPELTPHSSHA
>CP033946.1|AZB76744.1|2357788_2358793_+|LysR-family-transcriptional-regulator
MWSEYSLEVVDAVARNGSFSAAAQELHRVPSAVSYTVRQLEEWLAVPLFERRHRDVELTPAGVWFLQEGRSVIKKMQITRQQCQQIANGWRGQLSIAVDDIVKPARMRQMIVDFYRHFPDVELIVFQEVFNGVWDALADGRVELAIGATRSIPVGGRYAFRDMGMLSWDCVVASDHPLAKMDGPLSDDVLRNWPSLVREDTSRSLPKRTTWLLDNQKRVVVPDWESSATCLSAGLCVGMVPSHFARPWIDRGEWTALALENPFPDAACCLTWQQNDASPALNWMLDYLGDSDTLNREWLRAPERSAPARCLNDDNRQTGHPLPSGAQPDEGALR
>CP033946.1|AZB76745.1|2358719_2359745_-|PurR-family-transcriptional-regulator
MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTKSIGLLATSSEAAYFAEIIESVEKSCFQKGYTLILGNAWNDLEKQRAYLSMMAQKRVDGLLVMCSEYPDSVLSMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFQGGYIAGRYLIERGHREIGVIPGPLERNTGAGRLAGFMQAMKEAHISVPENWIVQGDFEPESGYRAMQQILNQQHRPTAVFCGGDIMAMGAICAADEMGLRVPQDISLIGYDNVRNARYFSPALTTIHQPKDSLGEAAFNMLLDRIVNKREESQSIEVHPRLVERRSVADGPFVDYRR
>CP033946.1|AZB79469.1|2360040_2360130_+|YnhF-family-membrane-protein
MDTNLKFSLITTIIALGVIVAFSLTAILH
>CP033946.1|AZB76746.1|2360297_2361464_+|MFS-transporter
MKINFPLLALAIGAFGIGTTEFSPMGLLPVIAKGVDVSIPVAGMLISAYAIGVMVGAPLMTLLLSHRARRNALIFLMGIFTVGNLLSSIAPDYTTLLLSRIITSLNHGAFFGLGSVVAASVVPKHKQASAVATMFMGLTIANIGGVPAATWLGETIGWRMSFLATAGLGLLAMVSLWFSLPKGSAGERPDVKKELSVLLRPQVLSALLTTVLGAGAMFTLYTYISPVLNTLTHASSLFITAMLVLIGVGFSLGNYLGGKFADRSVSGTLKGFLLLLMAIMLAIPLLAQSQAGAAISMIVWGAATFAVVPPLQMRVMRVAHEAPGLSSSVNIGAFNLGNALGAAAGGAVISGGLGYAFVPVMGAIIAGLALLLVWFSGRAQPEEAFASQ

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Crispr_ID: CP033946_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP033946_3

4244015-4244151

Orphan

Consensus_repeat	Method
TGCCGGGTGGCGGCTGGCGCCTTACCCGGCCTACAAAACCGAAGCAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP033946_3

>merge|CP033946|3|4244015-4244151|CRISPRCasFinder
TGCCGGGTGGCGGCTGGCGCCTTACCCGGCCTACAAAACCGAAGCAGTTGACCCGGCAAGCGCAGCGCCGCCGGGCACGGAGCCGCTTTATGCCGGGTGGCGGCTGGCGCCTTACCCGGCCTACAAAACTGAAGCAG

>CP033946|3|3|4244015-4244151|CRISPRCasFinder
TGCCGGGTGGCGGCTGGCGCCTTACCCGGCCTACAAAACCGAAGCAG	TTGACCCGGCAAGCGCAGCGCCGCCGGGCACGGAGCCGCTTTA
TGCCGGGTGGCGGCTGGCGCCTTACCCGGCCTACAAAACTGAAGCAG

Protein	Signature genes	Signature genes Name	Protein_function
CP033946.1\|AZB78436.1\|4241883_4242939_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|235035
CP033946.1\|AZB78429.1\|4235421_4236219_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187602
CP033946.1\|AZB78441.1\|4246238_4246877_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-D	unknown	unknown	gnl\|CDD\|236457
CP033946.1\|AZB78445.1\|4250198_4250408_+\|hypothetical-protein	unknown	unknown	unknown
CP033946.1\|AZB78438.1\|4244181_4244397_-\|(Na+)-NQR-maturation-NqrM	unknown	unknown	gnl\|CDD\|225538
CP033946.1\|AZB78431.1\|4237406_4237805_-\|Crl-family-RNA-polymerase-assembly-factor	unknown	unknown	gnl\|CDD\|182882
CP033946.1\|AZB78435.1\|4241428_4241881_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|182099
CP033946.1\|AZB78440.1\|4245635_4246232_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E	unknown	unknown	gnl\|CDD\|235074
CP033946.1\|AZB78444.1\|4248898_4250242_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-A	unknown	unknown	gnl\|CDD\|235426
CP033946.1\|AZB78446.1\|4250653_4251394_+\|transpeptidase	unknown	unknown	gnl\|CDD\|225577
CP033946.1\|AZB78437.1\|4243098_4243959_+\|glycerophosphodiester-phosphodiesterase	unknown	unknown	gnl\|CDD\|176522
CP033946.1\|AZB78430.1\|4236251_4236668_+\|SRPBCC-family-protein	unknown	unknown	gnl\|CDD\|176863
CP033946.1\|AZB78432.1\|4237862_4239107_-\|esterase-FrsA	unknown	unknown	gnl\|CDD\|235337
CP033946.1\|AZB78433.1\|4239212_4239671_-\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|236395
CP033946.1\|AZB78447.1\|4251364_4252132_-\|class-II-glutamine-amidotransferase	unknown	unknown	gnl\|CDD\|372525
CP033946.1\|AZB78439.1\|4244399_4245623_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-F	unknown	unknown	gnl\|CDD\|235481
CP033946.1\|AZB78434.1\|4239928_4241386_+\|cytosol-nonspecific-dipeptidase	unknown	unknown	gnl\|CDD\|184986
CP033946.1\|AZB78443.1\|4247656_4248895_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-B	unknown	unknown	gnl\|CDD\|235425
CP033946.1\|AZB79564.1\|4236825_4237038_+\|DUF1471-domain-containing-protein	unknown	unknown	gnl\|CDD\|369322
CP033946.1\|AZB78442.1\|4246869_4247664_-\|Na(+)-translocating-NADH-quinone-reductase-subunit-C	unknown	unknown	gnl\|CDD\|235423

Protein	Function_ID	Function_description	E-value
CP033946.1\|AZB78436.1\|4241883_4242939_-\|DNA-polymerase-IV	gnl\|CDD\|235035	PRK02406, PRK02406, DNA polymerase IV; Validated.	0
CP033946.1\|AZB78429.1\|4235421_4236219_+\|SDR-family-oxidoreductase	gnl\|CDD\|187602	cd05344, BKR_like_SDR_like, putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR. This subgroup resembles the SDR family, but does not have a perfect match to the NAD-binding motif or the catalytic tetrad characteristic of the SDRs. It includes the SDRs, Q9HYA2 from Pseudomonas aeruginosa PAO1 and APE0912 from Aeropyrum pernix K1. BKR catalyzes the NADPH-dependent reduction of ACP in the first reductive step of de novo fatty acid synthesis (FAS). FAS consists of four elongation steps, which are repeated to extend the fatty acid chain through the addition of two-carbo units from malonyl acyl-carrier protein (ACP): condensation, reduction, dehydration, and a final reduction. Type II FAS, typical of plants and many bacteria, maintains these activities on discrete polypeptides, while type I FAS utilizes one or two multifunctional polypeptides. BKR resembles enoyl reductase, which catalyzes the second reduction step in FAS. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRS are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes have a 3-glycine N-terminal NAD(P)(H)-binding pattern (typically, TGxxxGxG in classical SDRs and TGxxGxxG in extended SDRs), while substrate binding is in the C-terminal region. A critical catalytic Tyr residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering), is often found in a conserved YXXXK pattern. In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) or additional Ser, contributing to the active site. Substrates for these enzymes include sugars, steroids, alcohols, and aromatic compounds. The standard reaction mechanism is a proton relay involving the conserved Tyr and Lys, as well as Asn (or Ser). Some SDR family members, including 17 beta-hydroxysteroid dehydrogenase contain an additional helix-turn-helix motif that is not generally found among SDRs.	1.29477e-50
CP033946.1\|AZB78441.1\|4246238_4246877_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-D	gnl\|CDD\|236457	PRK09292, PRK09292, Na(+)-translocating NADH-quinone reductase subunit D; Validated.	1.0782e-142
CP033946.1\|AZB78438.1\|4244181_4244397_-\|(Na+)-NQR-maturation-NqrM	gnl\|CDD\|225538	COG2991, COG2991, Uncharacterized protein conserved in bacteria [Function unknown].	5.41902e-29
CP033946.1\|AZB78431.1\|4237406_4237805_-\|Crl-family-RNA-polymerase-assembly-factor	gnl\|CDD\|182882	PRK10984, PRK10984, sigma factor-binding protein Crl.	2.69204e-83
CP033946.1\|AZB78435.1\|4241428_4241881_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|182099	PRK09831, PRK09831, GNAT family N-acetyltransferase.	2.97281e-85
CP033946.1\|AZB78440.1\|4245635_4246232_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E	gnl\|CDD\|235074	PRK02830, PRK02830, Na(+)-translocating NADH-quinone reductase subunit E; Provisional.	4.25239e-127
CP033946.1\|AZB78444.1\|4248898_4250242_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-A	gnl\|CDD\|235426	PRK05352, PRK05352, Na(+)-translocating NADH-quinone reductase subunit A; Provisional.	0
CP033946.1\|AZB78446.1\|4250653_4251394_+\|transpeptidase	gnl\|CDD\|225577	COG3034, COG3034, Uncharacterized protein conserved in bacteria [Function unknown].	1.3611e-109
CP033946.1\|AZB78437.1\|4243098_4243959_+\|glycerophosphodiester-phosphodiesterase	gnl\|CDD\|176522	cd08580, GDPD_Rv2277c_like, Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized bacterial protein Rv2277c and similar proteins. Members in this subfamily are bacterial homologous of mammalian GDE4, a transmembrane protein whose cellular function has not yet been elucidated.	7.97848e-129
CP033946.1\|AZB78430.1\|4236251_4236668_+\|SRPBCC-family-protein	gnl\|CDD\|176863	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins. The PYR/PYL/RCAR-like family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. PYR/PYL/RCAR plant proteins are receptors involved in signal transduction. They bind abscisic acid (ABA) and mediate its signaling. ABA is a vital plant hormone, which regulates plant growth, development, and response to environmental stresses. Upon binding ABA, these plant proteins interact with a type 2C protein phosphatase (PP2C), such as ABI1 and ABI2, and inhibit their activity. When ABA is bound, a loop (designated the gate/CL2 loop) closes over the ligand binding pocket, resulting in the weakening of the inactive PYL dimer and facilitating type 2C protein phosphatase binding. In the ABA:PYL1:ABI1 complex, the gate blocks substrate access to the phosphatase active site. A conserved Trp from PP2C inserts into PYL to lock the receptor in a closed formation. This group also contains Methylobacterium extorquens AM1 MxaD. The mxaD gene is located within the mxaFJGIR(S)ACKLDEHB cluster which encodes proteins involved in methanol oxidation. MxaD may participate in the periplasmic electron transport chain for oxidation of methanol. Mutants lacking MxaD exhibit a reduced growth on methanol, and a lower rate of respiration with methanol.	9.9091e-45
CP033946.1\|AZB78432.1\|4237862_4239107_-\|esterase-FrsA	gnl\|CDD\|235337	PRK05077, frsA, esterase FrsA.	0
CP033946.1\|AZB78433.1\|4239212_4239671_-\|xanthine-phosphoribosyltransferase	gnl\|CDD\|236395	PRK09177, PRK09177, xanthine-guanine phosphoribosyltransferase; Validated.	2.19173e-113
CP033946.1\|AZB78447.1\|4251364_4252132_-\|class-II-glutamine-amidotransferase	gnl\|CDD\|372525	pfam13230, GATase_4, Glutamine amidotransferases class-II. This family captures members that are not found in pfam00310.	1.08772e-144
CP033946.1\|AZB78439.1\|4244399_4245623_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-F	gnl\|CDD\|235481	PRK05464, PRK05464, Na(+)-translocating NADH-quinone reductase subunit F; Provisional.	0
CP033946.1\|AZB78434.1\|4239928_4241386_+\|cytosol-nonspecific-dipeptidase	gnl\|CDD\|184986	PRK15026, PRK15026, aminoacyl-histidine dipeptidase; Provisional.	0
CP033946.1\|AZB78443.1\|4247656_4248895_-\|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-B	gnl\|CDD\|235425	PRK05349, PRK05349, Na(+)-translocating NADH-quinone reductase subunit B; Provisional.	0
CP033946.1\|AZB79564.1\|4236825_4237038_+\|DUF1471-domain-containing-protein	gnl\|CDD\|369322	pfam07338, DUF1471, Protein of unknown function (DUF1471). This family consists of several hypothetical Enterobacterial proteins of around 90 residues in length. Some members of this family are annotated as ydgH precursors and contain two copies of this region, one at the N-terminus and the other at the C-terminus. The function of this family is unknown.	5.26043e-05
CP033946.1\|AZB78442.1\|4246869_4247664_-\|Na(+)-translocating-NADH-quinone-reductase-subunit-C	gnl\|CDD\|235423	PRK05346, PRK05346, Na(+)-translocating NADH-quinone reductase subunit C; Provisional.	1.37213e-153

>CP033946.1|AZB78437.1|4243098_4243959_+|glycerophosphodiester-phosphodiesterase
MKKILTALCLLATAGAWAAPQLIAHRGGTGDAPENTLPAIKLALENNAEAIWVTVQLSRDGVPVLYRSSDLSALTNSEGKVSSLTAAELAKVDAGWKWGDDSHPWRGKQATIPTLQSVLQQWPHTFFYIDIKSPDADPTVMGQRLLEVLKTTDSLDRVRVYSTEDRYIAALPPAIPRFVTRSETRTRLANISLSHQCQPASQRDGEQWYGLELKRKVEVVEKFTLGEGISPATLTWDKEAMDCFRSQDKAHIIFFGINSAEDYRTAIELGADGVMVDSPAQAKSWQ
>CP033946.1|AZB78436.1|4241883_4242939_-|DNA-polymerase-IV
MRKIIHVDMDCFFAAVEMRDNPALRDIPLAIGGSRVQRGVISTANYPARKFGVRSAMPTATALKLCPHLTLLPGRFDAYKEASNHIREIFSRYTSRIEPLSLDEAYLDVSDSEHCHGSATLIAQEIRQTIERELRLTASAGVAPVKFLAKIASDMNKPNGQFVIAPHQVAEFVRALPLAKIPGVGKVSAAKLENMGLRTCGDVQNSDLAMLLKRFGKFGRILWERSHGIDEREIHNDRQRKSVGVERTLAEDIHEWPECEAIIENLYPELERRLAKVKPDLLIARQGIKLKFNDFQLTTQEHVWPRLNKEDLIATAHKAWDERRGGRGVRLVGLHVTLLDPQLERQLLLGI
>CP033946.1|AZB78435.1|4241428_4241881_-|GNAT-family-N-acetyltransferase
MHIRAYRDSDLPLLCQIFLRAVWETASRDYTPGQIAAWAQVDETRWRQKLADSIGLVAVVNSQPVGFITAIGTHIDLLFVSPDRARQGIGGALIEALCAQYPAQILTVDASITAKPCFTAHGFKVVAEQRVAARGEWFINYRMEKRVALR
>CP033946.1|AZB78434.1|4239928_4241386_+|cytosol-nonspecific-dipeptidase
MSELSQLSPQPLWDIFAKICSIPHPSYHEEQLAEHIMGWAKEKGLHAERDQVGNILIRKGATAGMENRRPVALQAHLDMVPQKNNDTVHDFVKDPIQPYIDGEWVKARGTTLGADNGIGMASALAVLADDSVAHGPLEVLLTMTEEAGMDGAFGLQANWLQADILINTDSEEEGEIYMGCAGGIDFTSNLALTREAIPAGFQSFKVTLKGLKGGHSGGDIHLGLGNANKLLSRFLAGHADELDLRLVDFNGGTLRNAIPREAYATVAVAADKADALKALVNTYQALLKNELEAKEKNLVVLVEAVDNDKAALTQASRDTFIRLLNATPNGVIRNSDVAKGVVETSLNVGVVTMTDDNVQIHCLIRSLIDSGKDYVVSMLDSLGKLAGAKTEAKGAYPGWQPDANSPVMHLVRETYQRLFNKTPNIQIIHAGLECGLFKKPYPEMDMVSIGPTITGPHSPDEQVHIESVGQYWTLLTELLKAIPAK
>CP033946.1|AZB78433.1|4239212_4239671_-|xanthine-phosphoribosyltransferase
MSEKYVVTWDMLQIHARKLASRLLPVEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVVDIPQDTWIEQPWDMGVVFVPPIAGR
>CP033946.1|AZB78432.1|4237862_4239107_-|esterase-FrsA
MSQANLSETLFKPRFKHPETSTLVRRFSAGKPQAMQSALSGNHVDHWYRLINRLMWIWRGVTPQEILDVQARIVMSEAERTDPELFDTVIGYRGGNWIFEWAKEAMQWQQKAGQEADPLLSGRHWLHASNLYSIAAYPHIKGDELAEQAQALANRAYEEAAQRLPGSLRELEFTIPGGSPITGFLHMPKGEGPFPTVLMCGGLDSLQTDYYNLYENYFSPLGIAMLTIDMPSIGFSSKWTLNQDTSLLHQHALRHLENVPWVDHTRVAAFGFRFGANIAVRLGYLEPQRLKAVACLGPVVHGLLVDPLHQGRVPEMYLDVLASRLGMHDASDEALRVELNRYSLKTQGLLGRRCPTPMLSGFWKDDPFSPEEESRLITSSSADGKLLEIPFNPVYRNFDHALRQIARWINHRFG
>CP033946.1|AZB78431.1|4237406_4237805_-|Crl-family-RNA-polymerase-assembly-factor
MTLPSGHLKSKLIKKFTALGPYIREEQCHDNRFFFDCLAVCVNVKPAPEKREFWGWWMEMEAQESRFTYSYQFGLFNKEGSWQAVDIDDPEVSDRLEKTLREFHERAAALLTTFNLKLEPADDFSEPVRLRA
>CP033946.1|AZB79564.1|4236825_4237038_+|DUF1471-domain-containing-protein
MKTVSTIFSAAALSLFAFTASAHSVTATSNTLDSAEAMIAKKAKELNATDYKITSAHMGNKVTMSAVLDK
>CP033946.1|AZB78430.1|4236251_4236668_+|SRPBCC-family-protein
MATTTVSIEIPASVDQVWQLMGGFDSLPDWLPFIPKSMVSEGGRVRTLTTSDGGTVIERLEAFDNRQRSYSYSIIQAPFPVVDYLSTIAVVATADSNITRVEWSGSFTPVNVSDADAEALFSGIYRDGLQALKDNFSA
>CP033946.1|AZB78429.1|4235421_4236219_+|SDR-family-oxidoreductase
MKLDLTHKVAVVSGSTSGIGLGIAKGLAWAGATVVIVGRQQRGVDTAIAAINAEHPDAQLRGVVADLSTEEGVSALLAAEPHADVVVNNLGIFNDKDFFSVPDSEWMHFYNVNVLSGVRLSRHYAQGMIDNGWGRIIFVSSESGVAIPADMINYGVTKSANLAVSHGLAKRLAGTGVTVNAILPGPTFTEGLQEMLAEAATQSGRSPREQADEFVKTARPSSIIQRAADVDEVANLAVYLASPLSSATTGAALRVDGGVVDTLAM
>CP033946.1|AZB78438.1|4244181_4244397_-|(Na+)-NQR-maturation-NqrM
MLTVFIATFVIFALVILGMSLGYLVKRKSIQGSCGGISALGLEKVCDCPEPCDARKKRLAREAQRQQRRIL
>CP033946.1|AZB78439.1|4244399_4245623_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-F
MEIILGVVMFTLIVLVLSGLILAARSKLVNAGDVVIEINNEADKQIRTPAGDKLLNTLSSNGIFVSSACGGGGSCGQCRVTVKEGGGDILPTELSHITKRDAKAGCRLACQVAVKQNMKIELPEEIFGVKKWECEVISNDNKATFIKELKLRIPEGEVVPFRAGGYIQIECPPHKVAYADFDVPDEYRSDWDKFNLFRYVSEVKEPTLRAYSMANYPEEKGIIMLNVRIATPPPKVPDAPPGIMSSYIWSLKPGDKVTISGPFGEFFAKETDAEMVFIGGGAGMAPMRSHIFDQLKRLHSTRKISFWYGARSLREMFYDEEFEQLARDNPNFTFHVALSDPLPEDNWTGHTGFIHNVLYENYLRDHPAPEDCEFYMCGPPVMNAAVIKMLKDLGVEDENILLDDFGG
>CP033946.1|AZB78440.1|4245635_4246232_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-E
MAHYISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLRDGALVEGVDLSFLNFITFIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVAMAGIREKMKYANVPAGLRGLGITFITTGLMALGFMSFSGVQL
>CP033946.1|AZB78441.1|4246238_4246877_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-D
MAEQSDMKEVKRVLVGPLIANNPIALQVLGVCSALAVTTKLETAFVMTIAVTLVTAFSSMFISMIRHHIPNSVRIIVQMAIIASLVIVVDQLLRAFAYETSKQLSVFVGLIITNCIVMGRAEAYAMKSPPLASFMDGIGNGLGYGAILIIVGFLRELIGSGKLFGITVLETVQNGGWYQPNGLFLLAPSAFFIIGLLIWALRSWKPEQQEKE
>CP033946.1|AZB78442.1|4246869_4247664_-|Na(+)-translocating-NADH-quinone-reductase-subunit-C
MAEKKSNDSIGKTLLVVLVLCLVCSIVVAGSAVGLKSRQQAQRALDKQRNILAVSGLMHPGMDADAVADTFAARITPRLVNLATGELLEKDPGKFNQAQALKDPQQSMALDASQDPAGIKRRSNLAEIYLVRDAQQKIEQVVLPIYGNGLWSMMYAFVALDVDGRTVKGITYYDQGETPGLGGEVENPNWRQQFVGKQVLDDNGMPALKVVKGGARAGDLHAVDGLSGATLTSNGVQHSFDFWMGELGFGPFLKKVREGELNNG
>CP033946.1|AZB78443.1|4247656_4248895_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-B
MGLKHLIEKLEPHFTHGGKLEKYYPLYEAAATIFYTPGQVTRGAAHVRDAIDLKRMMILVWFAVFPAMFWGMYNVGLQTIPALHKLYGAEQLQQAIANNWHYSVAQWLGVSFSADAGWLSMMTLGAVFFLPIYITVFIVGGFWEVLFAIVRKHEINEGFFVTSILFALIVPPTLPLWQAALGISFGVVIAKEIFGGTGRNFLNPALAGRAFLFFAYPAQISGDLVWTAADGFSGATPLSQWASGGGEALVNVATGVPVSWMDAFLGNIPGSIGEVSTLMIFIGGAIILFGRVASWRIVAGVMIGMIATATLFNVIGSDTNPMFAMPWYWHLVLGGFAFGMMFMATDPVSASFTDKGKWSYGVLIGVMCVLIRVVNPAYPEGMMLAILFANLFAPLFDYLVVQANIKRRKSRG
>CP033946.1|AZB78444.1|4248898_4250242_-|NADH:ubiquinone-reductase-(Na(+)-transporting)-subunit-A
MIKITKGLDLPIAGMPLQQISPAPAVKRVALLGEEYVGMRPAMAVKEGDRVKKGQILFEDKKIPGVCFTAPASGIVSAIHRGERRVLQSVVIDIEGNDAVAFTRYAADALAELPRDTVQQQLLASGQWTALRTRPFSKTPLPGSTPAAIFVNAMDTNPLAAEPQPIILAERAAFDAGLTVLTRLTDGKVHVCQPSGGKLGGHPLGQVCFNQFSGPHPAGLPGTHIHFLEPVSLNKQVWHLNYQDAIAIGKLFLDGELYCERIIALGGPQVTSPRLVKTTLGASLEDLLAGELQEGENRVISGSVLSGARAHGPHAFLGRFHLQVSVVKEGREKELFGWVMPGKEKFSITRTTLGHFFKRKRFHFSTDTNGGERAMVPIGNYERVMPLDILPTILLRDLLAGDTDSAQALGCLELDEEDLALCTYVCPGKYEYGPALRSVLTRIEQEG
>CP033946.1|AZB78445.1|4250198_4250408_+|hypothetical-protein
MPAMGKSSPFVILIISLAGIRNLNPDAGQGQLIDRMAEKKGRNGASSAQDGREASFLTLMMNRRKCNIS
>CP033946.1|AZB78446.1|4250653_4251394_+|transpeptidase
MRKIALFIAMLLLPCVSFAGLLSSNSPTTPVSKEYKQQLMGSPVYIEIFKEERMLDLYVKMGETYQLLDSYRICNYSGGLGPKQRQGDFKSPEGFYNVTRSQLKPDSRFYKAINIGFPNAYDRAHGYEGKYLMIHGDCVSVGCYAMTDSGIDEIFQFVTGALVFGQPSVQVSIYPFRMTNANMERHKYSYYADFWKQLKPGYDYFQQTHKPPIVSVTDGRYVVSKPLSHEVVQPQLASNYTLPETK
>CP033946.1|AZB78447.1|4251364_4252132_-|class-II-glutamine-amidotransferase
MCELLGMSANVPTDICFSFTGLVQRGGGTGPHKDGWGITFYEGKGCRTFKDPQPSFQSPIAKLVQDYPIKSCSVVAHIRQANRGRVALENTHPFTRELWGRNWTYAHNGQLKGYKSLKTGNFHPVGETDSEKAFCWLLHRLTERYPRTPGNMLGVFKYIATLAGELREKGVFNMLLSDGRYVMAFCSTNLHWITRRAPFGVAKLLDQDVEIDFQRETTPNDVVTVIATQPLTANETWHKIMPGEWALFCLGERVV

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

89208 : 97585

Enterobacteria_phage(85.71%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZB74684.1\|89208_91530_-	DNA primase	Q7M2A8	Enterobacteria_phage	0.0e+00	83.2
AZB74685.1\|91544_91865_-	hypothetical protein	NA	NA	NA	NA
AZB74686.1\|91861_92089_-	hypothetical protein	NA	NA	NA	NA
AZB74687.1\|92085_92637_-	host cell division inhibitor Icd-like protein	Q7M2A7	Enterobacteria_phage	8.6e-36	67.2
AZB74688.1\|93437_93902_+	hypothetical protein	Q7M2A2	Enterobacteria_phage	1.8e-34	60.0
AZB74689.1\|94016_95558_+\|transposase	IS21-like element ISEc12 family transposase	K4I413	Acidithiobacillus_phage	1.3e-129	46.4
AZB79371.1\|95572_96319_+	ATP-binding protein	U5N3V8	Enterobacteria_phage	3.5e-24	31.6
AZB74690.1\|96756_97002_+	hypothetical protein	Q7M294	Enterobacteria_phage	4.8e-31	76.5
AZB74691.1\|97018_97585_+	phage polarity suppression protein	Q7M2A1	Enterobacteria_phage	3.2e-54	61.1

DBSCAN-SWA_2

1629469 : 1636374

Planktothrix_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZB76095.1\|1629469_1630333_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	5.7e-10	27.5
AZB76096.1\|1630343_1631117_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.1e-25	36.3
AZB79431.1\|1631357_1632251_-	lipid kinase YegS	A0A1V0SBJ0	Catovirus	2.1e-15	30.2
AZB76097.1\|1632496_1633858_-	U32 family peptidase	Q6DW11	Phage_TP	1.8e-207	94.8
AZB76098.1\|1634176_1634899_-	two-component system response regulator BaeR	W8CYM9	Bacillus_phage	8.3e-31	33.2
AZB76099.1\|1634895_1636374_-	two-component system sensor histidine kinase BaeS	W8CYF6	Bacillus_phage	1.4e-29	28.3

DBSCAN-SWA_3

1893336 : 1923226

Escherichia_phage(26.47%)

lysis,tRNA,terminase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZB76306.1\|1893336_1895070_-\|tRNA	arginine--tRNA ligase	A0A2K9L6Z2	Tupanvirus	1.4e-87	33.8
AZB76307.1\|1895305_1895875_+	VOC family protein	NA	NA	NA	NA
AZB76308.1\|1895951_1896695_+	copper homeostasis protein CutC	NA	NA	NA	NA
AZB76309.1\|1896776_1897781_-\|tRNA	tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB	NA	NA	NA	NA
AZB76310.1\|1897777_1898521_-	carboxy-S-adenosyl-L-methionine synthase CmoA	F5B419	Synechococcus_phage	4.1e-25	30.0
AZB76311.1\|1898560_1898956_-	hypothetical protein	NA	NA	NA	NA
AZB76312.1\|1899008_1899788_-	DUF72 domain-containing protein	Q859D1	Escherichia_coli_phage	1.1e-60	82.7
AZB76313.1\|1899784_1901044_-	DUF3596 domain-containing protein	A0A286S1S8	Klebsiella_phage	2.3e-225	89.9
AZB76314.1\|1901086_1901332_-	excisionase	A0A286S2A4	Klebsiella_phage	3.8e-36	93.4
AZB76315.1\|1901335_1901554_-	TraR/DksA family transcriptional regulator	A0A0K2FI84	Escherichia_phage	2.6e-12	52.2
AZB76316.1\|1901550_1901742_-	DUF1382 family protein	A0A0P0ZC60	Stx2-converting_phage	6.0e-13	62.7
AZB76317.1\|1901738_1902356_-	HNH endonuclease	A0A1W6DY33	Salmonella_phage	7.8e-38	47.0
AZB76318.1\|1902241_1902463_-	hypothetical protein	NA	NA	NA	NA
AZB76319.1\|1902459_1902987_-	phage N-6-adenine-methyltransferase	Q9ZWX6	Enterobacteria_phage	1.2e-55	59.8
AZB76320.1\|1903015_1903639_-	exonuclease	A0A0S2SY31	Pseudomonas_phage	9.0e-58	59.7
AZB76321.1\|1903635_1904382_-	phage recombination protein Bet	A0A0M4RD39	Salmonella_phage	3.1e-65	67.7
AZB76322.1\|1904398_1904683_-	host nuclease inhibitor GamL	G8C7T1	Escherichia_phage	5.2e-29	61.7
AZB76323.1\|1904690_1905692_-	hypothetical protein	M9P0E1	Enterobacteria_phage	4.2e-65	90.4
AZB76324.1\|1905779_1905974_-	hypothetical protein	NA	NA	NA	NA
AZB76325.1\|1906659_1907319_-	helix-turn-helix domain-containing protein	K7P7K3	Enterobacteria_phage	1.9e-69	61.5
AZB76326.1\|1907427_1907646_+	XRE family transcriptional regulator	A0A1P8DTF8	Proteus_phage	1.4e-13	50.7
AZB76327.1\|1907685_1907907_+	transcriptional regulator	G8EYH8	Enterobacteria_phage	6.9e-05	41.7
AZB76328.1\|1907992_1908853_+	replication protein	K7PGT1	Enterobacteria_phage	1.2e-60	53.6
AZB76329.1\|1908849_1909698_+	AAA family ATPase	K7PLU3	Enterobacteria_phage	1.2e-89	60.8
AZB76330.1\|1909694_1909988_+	protein ren	M1FPD5	Enterobacteria_phage	2.1e-25	62.4
AZB79448.1\|1910224_1910677_+	hypothetical protein	R9TME7	Aeromonas_phage	4.4e-14	40.6
AZB76331.1\|1910673_1910934_+	DUF4752 family protein	T1S9K2	Salmonella_phage	1.6e-29	75.6
AZB76332.1\|1911426_1911720_+	hypothetical protein	Q6UAT9	Klebsiella_phage	2.7e-44	86.6
AZB79449.1\|1911827_1912388_+	DUF551 domain-containing protein	A5LH60	Enterobacteria_phage	2.7e-05	30.3
AZB76333.1\|1912387_1912636_+	hypothetical protein	NA	NA	NA	NA
AZB76334.1\|1912801_1913122_+	hypothetical protein	NA	NA	NA	NA
AZB76335.1\|1913473_1913911_+	recombination protein NinB	G8C7V3	Escherichia_phage	7.4e-59	77.7
AZB76336.1\|1913910_1914078_+	NinE family protein	G8C7V4	Escherichia_phage	6.2e-14	75.0
AZB76337.1\|1914074_1914749_+	serine/threonine protein phosphatase	K7P6H8	Enterobacteria_phage	5.1e-99	74.0
AZB76338.1\|1914741_1915323_+	recombination protein NinG	E7C9S3	Salmonella_phage	8.7e-39	43.8
AZB76339.1\|1915319_1915460_+	YlcG family protein	NA	NA	NA	NA
AZB76340.1\|1915456_1916146_+	antiterminator	I6PDF8	Cronobacter_phage	1.9e-56	54.5
AZB76341.1\|1916490_1917015_-	hypothetical protein	NA	NA	NA	NA
AZB76342.1\|1917442_1917691_+\|lysis	lysis protein	NA	NA	NA	NA
AZB76343.1\|1917693_1918224_+	lysozyme	G9L6J6	Escherichia_phage	2.7e-79	79.1
AZB76344.1\|1918220_1918688_+\|lysis	lysis protein	A0A2D1GLQ7	Escherichia_phage	2.8e-56	73.5
AZB76345.1\|1918896_1919637_+	hypothetical protein	A0A1I9KFG9	Aeromonas_phage	8.0e-13	28.1
AZB76346.1\|1919640_1920972_+\|terminase	terminase	A0A0U2JTW9	Escherichia_phage	4.6e-152	59.7
AZB76347.1\|1920983_1922399_+	DUF1073 domain-containing protein	A0A0U2S5X9	Escherichia_phage	7.2e-87	36.3
AZB76348.1\|1922395_1923226_+	hypothetical protein	A0A0U2I1R8	Escherichia_phage	4.0e-53	41.9

DBSCAN-SWA_4

1942720 : 1950756

Enterobacteria_phage(16.67%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZB76369.1\|1942720_1942960_+	hypothetical protein	K7P7N3	Enterobacteria_phage	1.3e-17	53.2
AZB76370.1\|1942959_1943277_+	hypothetical protein	K7PGV5	Enterobacterial_phage	5.3e-22	51.0
AZB76371.1\|1943288_1944347_+	hypothetical protein	A0A1I9SEW2	Klebsiella_phage	2.3e-37	56.3
AZB76372.1\|1944655_1945222_-	hydrolase	NA	NA	NA	NA
AZB76373.1\|1945489_1947277_+\|tRNA	aspartate--tRNA ligase	A0A2K9L3L6	Tupanvirus	1.3e-11	27.2
AZB76374.1\|1947278_1947722_+	dihydroneopterin triphosphate diphosphatase	NA	NA	NA	NA
AZB76375.1\|1947749_1948490_+	YebC/PmpR family DNA-binding transcriptional regulator	NA	NA	NA	NA
AZB76376.1\|1948524_1949046_+	crossover junction endodeoxyribonuclease RuvC	G3MA90	Bacillus_virus	3.4e-10	35.1
AZB76377.1\|1949125_1949737_+	Holliday junction branch migration protein RuvA	NA	NA	NA	NA
AZB76378.1\|1949745_1950756_+	Holliday junction branch migration DNA helicase RuvB	A0A127AWE7	Bacillus_phage	1.4e-07	24.3

DBSCAN-SWA_5

2758488 : 2769375

Escherichia_phage(87.5%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZB77121.1\|2758488_2761596_+	beta-galactosidase	L0N6M2	Herpes_simplex_virus	0.0e+00	59.6
AZB77122.1\|2761650_2762916_+	MFS transporter	NA	NA	NA	NA
AZB77123.1\|2762946_2764035_-	chromosome segregation protein SMC	A0A077SLJ9	Escherichia_phage	8.0e-211	100.0
AZB77124.1\|2764121_2764382_-	hypothetical protein	A0A077SK33	Escherichia_phage	1.6e-40	97.7
AZB77125.1\|2764679_2765540_+	class A broad-spectrum beta-lactamase SHV-1	A0A077SL40	Escherichia_phage	4.4e-156	99.7
AZB77126.1\|2765560_2766322_-	DeoR/GlpR transcriptional regulator	A0A077SK06	Escherichia_phage	1.9e-134	100.0
AZB77127.1\|2766582_2767485_+	NAD(P)-dependent oxidoreductase	A0A077SLF7	Escherichia_phage	2.6e-159	99.7
AZB77128.1\|2767496_2768762_+	four-carbon acid sugar kinase family protein	A0A077SLJ7	Escherichia_phage	7.8e-234	99.8
AZB77129.1\|2768754_2769375_+	aldolase	A0A077SK32	Escherichia_phage	8.0e-115	100.0

DBSCAN-SWA_6

3163243 : 3236207

Klebsiella_phage(23.08%)

portal,tail,holin,integrase,tRNA,protease,terminase

attL 3190060:3190074|attR 3236547:3236561

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZB77476.1\|3163243_3163744_+\|tRNA	YbaK/prolyl-tRNA synthetase associated domain-containing protein	NA	NA	NA	NA
AZB77477.1\|3163860_3164307_+	DUF441 domain-containing protein	NA	NA	NA	NA
AZB79508.1\|3164290_3165082_-	AraC family transcriptional regulator	NA	NA	NA	NA
AZB77478.1\|3165183_3166368_+	MFS transporter	NA	NA	NA	NA
AZB77479.1\|3166399_3167092_-	hypothetical protein	NA	NA	NA	NA
AZB77480.1\|3167237_3167747_+	DUF523 domain-containing protein	NA	NA	NA	NA
AZB79509.1\|3167733_3168090_+	DUF488 domain-containing protein	NA	NA	NA	NA
AZB77481.1\|3168079_3168319_-	DUF333 domain-containing protein	NA	NA	NA	NA
AZB77482.1\|3168619_3169633_+	sensor domain-containing diguanylate cyclase	G3MA91	Bacillus_virus	1.1e-12	33.8
AZB77483.1\|3169690_3169792_+	hypothetical protein	NA	NA	NA	NA
AZB79510.1\|3169791_3169866_+	protein YoaJ	NA	NA	NA	NA
AZB77484.1\|3169983_3170109_+	hypothetical protein	NA	NA	NA	NA
AZB77485.1\|3170168_3170432_-	DUF2534 family protein	NA	NA	NA	NA
AZB77486.1\|3170562_3171201_-	leucine efflux protein LeuE	NA	NA	NA	NA
AZB77487.1\|3171290_3172205_-	kdo(2)-lipid IV(A) palmitoleoyltransferase	A0A1W6JP29	Morganella_phage	1.1e-72	50.4
AZB77488.1\|3172420_3172612_+	hypothetical protein	NA	NA	NA	NA
AZB77489.1\|3172866_3173910_-	type II asparaginase	NA	NA	NA	NA
AZB77490.1\|3174212_3175421_+	HD domain-containing protein	NA	NA	NA	NA
AZB77491.1\|3175494_3177279_+	sensor domain-containing diguanylate cyclase	A0A127AWB9	Bacillus_phage	5.8e-17	36.1
AZB77492.1\|3177285_3178176_-	LysR family transcriptional regulator	NA	NA	NA	NA
AZB77493.1\|3178296_3179805_+	UbiD family decarboxylase	NA	NA	NA	NA
AZB77494.1\|3180115_3180802_-	EAL domain-containing protein	NA	NA	NA	NA
AZB77495.1\|3181200_3181380_-	hypothetical protein	NA	NA	NA	NA
AZB77496.1\|3181419_3182052_-	DNA-binding protein	NA	NA	NA	NA
AZB77497.1\|3182618_3182816_+	hypothetical protein	NA	NA	NA	NA
AZB77498.1\|3182931_3183942_-	cytochrome d ubiquinol oxidase subunit II	NA	NA	NA	NA
AZB77499.1\|3183938_3185345_-	cytochrome ubiquinol oxidase subunit I	NA	NA	NA	NA
AZB77500.1\|3185400_3186288_-	manganese catalase family protein	NA	NA	NA	NA
AZB77501.1\|3186304_3186811_-	ferritin-like domain-containing protein	NA	NA	NA	NA
AZB77502.1\|3186837_3187332_-	ferritin-like domain-containing protein	NA	NA	NA	NA
AZB77503.1\|3187422_3187608_-	stress-induced acidophilic repeat motif-containing protein	NA	NA	NA	NA
AZB77504.1\|3188230_3189424_+	glutathione-dependent formaldehyde dehydrogenase	NA	NA	NA	NA
AZB77505.1\|3189536_3189764_+	DUF1272 domain-containing protein	NA	NA	NA	NA
AZB77506.1\|3189784_3189970_-	hypothetical protein	NA	NA	NA	NA
3190060:3190074	attL	NA	NA	NA	NA
AZB77507.1\|3190213_3190537_+	antibiotic biosynthesis monooxygenase	NA	NA	NA	NA
AZB77508.1\|3190529_3190922_+	amino acid-binding protein	NA	NA	NA	NA
AZB77509.1\|3190918_3191632_+	ArsR family transcriptional regulator	NA	NA	NA	NA
AZB77510.1\|3191904_3192057_-	isocitrate dehydrogenase	Q77Z09	Phage_21	3.8e-18	92.0
AZB77511.1\|3192265_3193066_+	hypothetical protein	NA	NA	NA	NA
AZB77512.1\|3194101_3195808_-	hypothetical protein	NA	NA	NA	NA
AZB79511.1\|3196004_3196298_-	DUF4113 domain-containing protein	I6RSM4	Salmonella_phage	3.9e-27	80.0
AZB77513.1\|3197140_3197563_-	hypothetical protein	K7P834	Enterobacteria_phage	1.2e-24	43.8
AZB77514.1\|3197640_3197823_-	Hin recombinase	A0A286S1P7	Klebsiella_phage	1.8e-19	87.0
AZB77515.1\|3197833_3198634_-	hypothetical protein	NA	NA	NA	NA
AZB77516.1\|3200677_3203746_-	kinase	A0A286S259	Klebsiella_phage	0.0e+00	66.3
AZB77517.1\|3203742_3204129_-	nitrite transporter	A0A286S2A6	Klebsiella_phage	4.7e-33	50.8
AZB77518.1\|3204136_3204619_-	DUF1833 domain-containing protein	A0A286S2B1	Klebsiella_phage	8.5e-56	67.7
AZB77519.1\|3204605_3205079_-	hypothetical protein	A0A286S298	Klebsiella_phage	3.9e-53	63.5
AZB77520.1\|3205078_3207775_-\|tail	phage tail tape measure protein	K7PKR0	Enterobacteria_phage	2.2e-201	62.6
AZB77521.1\|3207755_3208073_-\|tail	phage tail assembly protein T	A0A0K2FJB3	Enterobacteria_phage	1.4e-19	51.5
AZB77522.1\|3208093_3208489_-\|tail	phage tail protein	M9NZD7	Enterobacteria_phage	1.9e-08	27.5
AZB77523.1\|3208531_3208714_-\|tail	phage tail protein	K7PGX1	Enterobacteria_phage	2.1e-15	72.7
AZB77524.1\|3208710_3209013_-	hypothetical protein	M9NYX0	Enterobacteria_phage	2.0e-34	70.2
AZB77525.1\|3209020_3209419_-\|tail	phage tail protein	K7PHM6	Enterobacterial_phage	3.2e-40	57.8
AZB77526.1\|3209415_3209967_-\|tail	phage tail protein	K7P7A8	Enterobacteria_phage	1.6e-53	67.3
AZB77527.1\|3209956_3210250_-	ATP-binding protein	NA	NA	NA	NA
AZB77528.1\|3210242_3210569_-	DUF2190 family protein	K7PJY3	Enterobacterial_phage	4.0e-33	66.4
AZB77529.1\|3210649_3212665_-\|protease	Clp protease ClpP	K7PKX4	Enterobacterial_phage	0.0e+00	84.6
AZB77530.1\|3212609_3214109_-\|portal	phage portal protein	K7PHM5	Enterobacterial_phage	1.9e-247	83.2
AZB77531.1\|3214105_3214321_-	hypothetical protein	A5LH28	Enterobacteria_phage	7.7e-25	77.1
AZB77532.1\|3214317_3216426_-\|terminase	phage terminase large subunit family protein	K7PH52	Enterobacterial_phage	0.0e+00	83.2
AZB77533.1\|3216425_3216917_-	DUF1441 family protein	K7PJY2	Enterobacterial_phage	6.4e-67	84.0
AZB77534.1\|3217238_3217424_-	hypothetical protein	Q8W634	Enterobacteria_phage	1.9e-11	61.1
AZB79512.1\|3217489_3217750_-	hypothetical protein	NA	NA	NA	NA
AZB77535.1\|3217975_3218221_-	DUF2560 family protein	A0A286N2R1	Klebsiella_phage	3.9e-33	95.1
AZB77536.1\|3218655_3218868_-	hypothetical protein	A0A286N2Q9	Klebsiella_phage	3.9e-21	70.0
AZB79513.1\|3219034_3219229_-	hypothetical protein	A0A286SGR9	Klebsiella_phage	1.1e-25	90.6
AZB77537.1\|3219179_3219455_-	hypothetical protein	G8C7W1	Escherichia_phage	7.3e-20	60.7
AZB77538.1\|3219451_3219796_-	hypothetical protein	A0A286N2Q7	Klebsiella_phage	2.0e-38	80.7
AZB77539.1\|3219792_3220332_-	hypothetical protein	A0A286N2Q6	Klebsiella_phage	2.3e-102	100.0
AZB79514.1\|3220328_3220628_-\|holin	holin	A0A286N2Q5	Klebsiella_phage	2.9e-46	99.0
AZB79515.1\|3221240_3221687_+	hypothetical protein	NA	NA	NA	NA
AZB77540.1\|3221592_3221850_-	hypothetical protein	A0A286N2Q3	Klebsiella_phage	2.8e-42	98.8
AZB77541.1\|3222162_3222741_-	DUF1133 family protein	A0A0U2S606	Escherichia_phage	7.6e-51	57.2
AZB77542.1\|3222754_3223735_-	DUF968 domain-containing protein	A0A291AWV9	Escherichia_phage	1.9e-134	66.9
AZB77543.1\|3223747_3224125_-	RusA family crossover junction endodeoxyribonuclease	A0A1C9IIA0	Salmonella_phage	2.3e-48	73.6
AZB77544.1\|3224134_3224944_-	Dam family site-specific DNA-(adenine-N6)-methyltransferase	A0A1C9II58	Salmonella_phage	5.9e-110	69.3
AZB77545.1\|3224940_3225894_-	helix-turn-helix domain-containing protein	U5P0A0	Shigella_phage	3.7e-103	75.5
AZB77546.1\|3225883_3226063_-	DUF4222 domain-containing protein	S5M7S5	Escherichia_phage	4.6e-15	73.1
AZB77547.1\|3226300_3226762_-	hypothetical protein	K7PJS5	Enterobacterial_phage	1.7e-69	88.2
AZB77548.1\|3226796_3227039_-	XRE family transcriptional regulator	A0A1C9IHV8	Salmonella_phage	1.3e-25	80.3
AZB77549.1\|3227136_3227832_+	helix-turn-helix transcriptional regulator	Q8HAA0	Salmonella_phage	3.2e-88	71.7
AZB77550.1\|3228133_3228493_+	hypothetical protein	NA	NA	NA	NA
AZB77551.1\|3228702_3229620_+	hypothetical protein	A0A1W6JP69	Morganella_phage	8.9e-46	36.5
AZB77552.1\|3229709_3230009_+	hypothetical protein	K7PJS4	Enterobacterial_phage	1.1e-13	48.6
AZB77553.1\|3230008_3230794_+	hypothetical protein	A4JX52	Burkholderia_virus	2.2e-61	50.6
AZB77554.1\|3231481_3231742_+	DUF4752 family protein	T1S9K2	Salmonella_phage	7.4e-30	75.0
AZB77555.1\|3231738_3231945_+	hypothetical protein	R9TRD3	Aeromonas_phage	1.1e-31	97.1
AZB77556.1\|3232596_3232965_+	hypothetical protein	A0A088CE95	Shigella_phage	1.1e-18	55.2
AZB77557.1\|3232957_3233176_+	hypothetical protein	G8C7S3	Escherichia_phage	2.7e-09	53.4
AZB77558.1\|3233175_3233448_+	hypothetical protein	K7PKM4	Enterobacterial_phage	4.4e-09	40.4
AZB77559.1\|3233476_3233713_+	excisionase	NA	NA	NA	NA
AZB77560.1\|3233702_3234845_+\|integrase	integrase	Q77Z02	Phage_21	5.9e-172	81.9
AZB77561.1\|3234956_3236207_-	NADP-dependent isocitrate dehydrogenase	Q77Z09	Phage_21	1.1e-19	92.6
3236547:3236561	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP033947

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. CP033948

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

3. CP033946

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection