CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
AP019307	Nocardioides baekrokdamisoli KCTC 39748 DNA, complete genome	2 crisprs	cas4,WYL,csa3,DEDDh,DinG,cas3	0	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: AP019307_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP019307_2

2202918-2203020

Orphan

Consensus_repeat	Method
CGGGACCTCGCTCGCTTCGCCGAG	CRISPRCasFinder

1 spacers

The CRISPR arrays of AP019307_2

>merge|AP019307|2|2202918-2203020|CRISPRCasFinder
CGGGACCTCGCTCGCTTCGCCGAGCGCCCGATGGGCGCTGGCTCACTCGCTCGGCGCCCGTGCACGCATAAATGCGGCACGGGACCTCGCTCGCTTCGCCTAG

>AP019307|2|2|2202918-2203020|CRISPRCasFinder
CGGGACCTCGCTCGCTTCGCCGAG	CGCCCGATGGGCGCTGGCTCACTCGCTCGGCGCCCGTGCACGCATAAATGCGGCA
CGGGACCTCGCTCGCTTCGCCTAG

Protein	Signature genes	Signature genes Name	Protein_function
AP019307.1\|BBH17889.1\|2206041_2206470_+\|putative-HTH-type-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
AP019307.1\|BBH17881.1\|2191357_2200171_-\|type-I-polyketide-synthase	unknown	unknown	gnl\|CDD\|227315
AP019307.1\|BBH17884.1\|2202027_2202849_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274044
AP019307.1\|BBH17876.1\|2187764_2188415_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223173
AP019307.1\|BBH17886.1\|2203539_2204907_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
AP019307.1\|BBH17894.1\|2210988_2212182_+\|elongation-factor-Tu-1	unknown	unknown	gnl\|CDD\|234596
AP019307.1\|BBH17887.1\|2204905_2205757_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378605
AP019307.1\|BBH17891.1\|2207887_2208262_+\|30S-ribosomal-protein-S12	unknown	unknown	gnl\|CDD\|235355
AP019307.1\|BBH17885.1\|2203085_2203484_+\|cold-shock-protein	unknown	unknown	gnl\|CDD\|239905
AP019307.1\|BBH17880.1\|2190854_2191367_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234610
AP019307.1\|BBH17882.1\|2200384_2200813_+\|polyketide-cyclase	unknown	unknown	gnl\|CDD\|176863
AP019307.1\|BBH17888.1\|2205728_2205965_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378488
AP019307.1\|BBH17875.1\|2186843_2187746_-\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176125
AP019307.1\|BBH17879.1\|2190345_2190966_+\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|380058
AP019307.1\|BBH17890.1\|2206466_2207708_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
AP019307.1\|BBH17892.1\|2208261_2208732_+\|30S-ribosomal-protein-S7	unknown	unknown	gnl\|CDD\|235398
AP019307.1\|BBH17883.1\|2200853_2202002_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238017
AP019307.1\|BBH17877.1\|2188453_2188711_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|133459
AP019307.1\|BBH17878.1\|2188707_2190207_-\|methylmalonyl-CoA-carboxyltransferase	unknown	unknown	gnl\|CDD\|227136
AP019307.1\|BBH17893.1\|2208805_2210920_+\|elongation-factor-G	unknown	unknown	gnl\|CDD\|234569

Protein	Function_ID	Function_description	E-value
AP019307.1\|BBH17889.1\|2206041_2206470_+\|putative-HTH-type-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	2.65971e-17
AP019307.1\|BBH17881.1\|2191357_2200171_-\|type-I-polyketide-synthase	gnl\|CDD\|227315	COG4982, COG4982, 3-oxoacyl-[acyl-carrier protein].	0
AP019307.1\|BBH17884.1\|2202027_2202849_-\|hypothetical-protein	gnl\|CDD\|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	4.89887e-36
AP019307.1\|BBH17876.1\|2187764_2188415_-\|hypothetical-protein	gnl\|CDD\|223173	COG0095, LplA, Lipoate-protein ligase A [Coenzyme metabolism].	6.77585e-12
AP019307.1\|BBH17886.1\|2203539_2204907_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.91875e-23
AP019307.1\|BBH17894.1\|2210988_2212182_+\|elongation-factor-Tu-1	gnl\|CDD\|234596	PRK00049, PRK00049, elongation factor Tu; Reviewed.	0
AP019307.1\|BBH17887.1\|2204905_2205757_+\|hypothetical-protein	gnl\|CDD\|378605	pfam11228, DUF3027, Protein of unknown function (DUF3027). This family of proteins with unknown function appears to be restricted to Actinobacteria.	2.98431e-93
AP019307.1\|BBH17891.1\|2207887_2208262_+\|30S-ribosomal-protein-S12	gnl\|CDD\|235355	PRK05163, rpsL, 30S ribosomal protein S12; Validated.	8.68002e-86
AP019307.1\|BBH17885.1\|2203085_2203484_+\|cold-shock-protein	gnl\|CDD\|239905	cd04458, CSP_CDS, Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. CSP expression is up-regulated by an abrupt drop in growth temperature. CSP's are also expressed under normal condition at lower level. The function of cold-shock proteins is not fully understood. They preferentially bind poly-pyrimidine region of single-stranded RNA and DNA. CSP's are thought to bind mRNA and regulate ribosomal translation, mRNA degradation, and the rate of transcription termination. The human Y-box protein, which contains a CSD, regulates transcription and translation of genes that contain the Y-box sequence in their promoters. This specific ssDNA-binding properties of CSD are required for the binding of Y-box protein to the promoter's Y-box sequence, thereby regulating transcription.	2.21362e-22
AP019307.1\|BBH17880.1\|2190854_2191367_-\|hypothetical-protein	gnl\|CDD\|234610	PRK00070, acpS, 4'-phosphopantetheinyl transferase; Provisional.	2.89611e-32
AP019307.1\|BBH17882.1\|2200384_2200813_+\|polyketide-cyclase	gnl\|CDD\|176863	cd07821, PYR_PYL_RCAR_like, Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins. The PYR/PYL/RCAR-like family belongs to the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. PYR/PYL/RCAR plant proteins are receptors involved in signal transduction. They bind abscisic acid (ABA) and mediate its signaling. ABA is a vital plant hormone, which regulates plant growth, development, and response to environmental stresses. Upon binding ABA, these plant proteins interact with a type 2C protein phosphatase (PP2C), such as ABI1 and ABI2, and inhibit their activity. When ABA is bound, a loop (designated the gate/CL2 loop) closes over the ligand binding pocket, resulting in the weakening of the inactive PYL dimer and facilitating type 2C protein phosphatase binding. In the ABA:PYL1:ABI1 complex, the gate blocks substrate access to the phosphatase active site. A conserved Trp from PP2C inserts into PYL to lock the receptor in a closed formation. This group also contains Methylobacterium extorquens AM1 MxaD. The mxaD gene is located within the mxaFJGIR(S)ACKLDEHB cluster which encodes proteins involved in methanol oxidation. MxaD may participate in the periplasmic electron transport chain for oxidation of methanol. Mutants lacking MxaD exhibit a reduced growth on methanol, and a lower rate of respiration with methanol.	1.52922e-16
AP019307.1\|BBH17888.1\|2205728_2205965_-\|hypothetical-protein	gnl\|CDD\|378488	pfam10745, DUF2530, Protein of unknown function (DUF2530). This family of proteins with unknown function appears to be restricted to mycobacteria.	0.0041195
AP019307.1\|BBH17875.1\|2186843_2187746_-\|LysR-family-transcriptional-regulator	gnl\|CDD\|176125	cd08434, PBP2_GltC_like, The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold. GltC, a member of the LysR family of bacterial transcriptional factors, activates the expression of gltA gene of glutamate synthase operon and is essential for cell growth in the absence of glutamate. Glutamate synthase is a heterodimeric protein that encoded by gltA and gltB, whose expression is subject to nutritional regulation. GltC also negatively auto-regulates its own expression. This substrate-binding domain has strong homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	9.02604e-79
AP019307.1\|BBH17879.1\|2190345_2190966_+\|TetR-family-transcriptional-regulator	gnl\|CDD\|380058	pfam17928, TetR_C_22, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor present in sco1712 proteins from Streptomyces coelicolo which act as a regulator of antibiotic production.	1.01793e-22
AP019307.1\|BBH17890.1\|2206466_2207708_+\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.2876e-66
AP019307.1\|BBH17892.1\|2208261_2208732_+\|30S-ribosomal-protein-S7	gnl\|CDD\|235398	PRK05302, PRK05302, 30S ribosomal protein S7; Validated.	2.28517e-98
AP019307.1\|BBH17883.1\|2200853_2202002_+\|hypothetical-protein	gnl\|CDD\|238017	cd00060, FHA, Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).	9.83592e-07
AP019307.1\|BBH17877.1\|2188453_2188711_-\|hypothetical-protein	gnl\|CDD\|133459	cd06850, biotinyl_domain, The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.	1.85612e-18
AP019307.1\|BBH17878.1\|2188707_2190207_-\|methylmalonyl-CoA-carboxyltransferase	gnl\|CDD\|227136	COG4799, COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism].	2.66679e-174
AP019307.1\|BBH17893.1\|2208805_2210920_+\|elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0

>AP019307.1|BBH17884.1|2202027_2202849_-|hypothetical-protein
MNLSSTRTRFRRLPGPARAGAEAVVLVVVAVCLALFIKSFFVQAFYVPSGSMYPTLQGGSGVKSDRILVEKPSYWFGGPSRGDIVVFKDPGGWLSGEESSTPTHGLTGLMATIGLFPGGGHLVKRVIGIGGDVIVCCDKKTGDLIINGHLLDGSGFLAPRDGLNAVMPPYSCDGIDASGLGVQPCVVGWKVKVPAGTVFVMGDNRADSRDSAAHLCRPTNDAAAANSHPLVTSCSGITAFVPIDDIVGKVVAVLWPANRFKFLSRPSAFASIN
>AP019307.1|BBH17883.1|2200853_2202002_+|hypothetical-protein
MALVTISYAPGSWILIAGRDVNVLLPESEKQRAASVWATIDSGAGFSEALDAIVSAGLAGLSAFALVAEEGDLTRAVVRGDLRVELRTAHDSTVVAGTGTWAEESLSGVQGVSVWAESAGEARLTLAEGLVRAAGYESGTAIAAAADSSPLAAPVPAAPVLSLVPSVSPFGLGSPAGLAEDEFDEDVNDLSDSAEEPLDAPEILGDADYFDDSATDDFGALGILPEPEPEPEPEPEPAPDFGMIPPPPAFPPPGPAHDVVPVHAPEPVVSQESVRLAFSHGDNVEVTGPVVVGRAPHPDRFSHLVDPLVVRVPSPHQEISGTHVAIAPNDDGGVQVTDLGSTNGTLIIRGGGAPEELRPGVGVSIARGDVIDLGDSLTIRVV
>AP019307.1|BBH17882.1|2200384_2200813_+|polyketide-cyclase
MTAPVRVRVVHRFSSDPATVFAALGEHENLGKIFAPFKITRLNDGSTSRNGAGSARTLRLGPVAFVETVTNAVPDELIEYAITSGVTPLRGHWGKQVLAPTSDGGTELIYTIGFNAIAPGLAAAIGVGLSNGIKRGLPKLVP
>AP019307.1|BBH17881.1|2191357_2200171_-|type-I-polyketide-synthase
MDGMSIAPPLPRTSSTSRTLLDQLASGTPFSVIFGGQGAPWLTGLAELVRTHAVEVGPLVAAAQERTSPVGGELLRSGQRFDPIPWLNALADSESIESDDASAAPSADEVVAPSLSIPGVLLGHIALVRGLRRLGLDPAAATVAIGHSQGRLAVELLSGMDEAEALAYAILIGAAVERTAREHGLLGAGMRSVSGPSHSELKAALAAAPQPSRLEIGLHNGPTSHVVTGPAAELRHLEDLIPGAVIDDLHIGAAYHHSELAAASDLAATWAAACGLDPDAARRLTDSAIVQPTDWAADVATLTSSAATWVLDLGPTDVASRLTSTDARAHGLTVVPTALNRGLRELTVPGGAPAPARSWTAYAPTVVTLPDGSTRAETAFTRLTGRSPILLAGMTPTTVDPAIVAAAANAGFWAELAGGGQVSEEIFAANVDRLGGLLEPGRTWAFNSLLLDPYLWRLQVEGKRLLPRARAAGAAVDGVIVTAGVPELEDAVRLVGDLRAVGVPYVAFKPGTLAQVRDVLAIADEVAPTPLIVQIEGGKAGGHHSWEDLDELLIKTYADLRARENVVVCVGGGIGTPDIAARYITGDWSIALGHPAMPLDGVLIGTAAMACLEATTSPQVKQLLVDTPGTDGWVKAGTARNGMASGHSQLGADIHEIDNTASRVGRLLDEVAGDADAVKARAGEIIEALNQTAKPYFGDAAQMTYAEWLTRFVDLAGTPTWLDSTLRDRFHTLLQRAEARLAPEDHGQIPTLWAESAEIEDGAAAIAALIEHYPSAESVQLHPVDVSFFVKVCRTAGKPVPFVPVLDAEVRRWWRSDSLWQAHDERYDADAVCVIPGPVAIAGITRVDEPVADLLQRFEDAVVDSVLADGDWPARVVGRRRDEHAEDALSLVLAAPDVVWGERTVTNPVHRLGGDWHVVDAARAEQRATGATLSATSPTSVELQIPTGDSAITLILRTTDGTPTGAAPVVEDAAESMIGLLNAMAGQRSGGHAQFHPGLATEHALVTDTGAHGTDAVLDALVGLTWPTVFHTLATRPDVVEGVLDLVHLDHVITGSIPTEPGVLDAEAEIVSVTDTEVGRVVTVDVSLTRGGAPVATLHERFAIRGRSGAARLTPPTAIAPDVRDTPRVVRVSATVTAPTDLHAFAAVTGDHNPLHTSVAVAQLAGLEGPIVHGMWISAVAQRVITEQTDRPIEAWSGQFLAPVMPGQEVTIQAARIGVRAGRELLTVVASVDGTTVFSGQALVGAPTTAYVFPGQGIQHPGMGMEAYGRSKAAREIWDRADAHTRSRLGFSILEVVRTNPTELDAADGRHKHPDGVLFLTQFTQVAMAVLASAQMAELVESGLVVEDAYVAGHSVGEYNALAAVAGVISLEAVVEVVYQRGSVMHRLVPRDAEGRSDYRLAAIRPSQIDLADDDVLAFVETVSAESGEFLQIVNYNLRGSQYAIAGTVAGCKALETEVERRRAAAGGRGAFVLVPGIDVPFHSSVLRAGVPDFRSSLEALLPAEIDPALLLGRYVPNLVARPFSLDEEFLRSILEVAPAEPIEAALADFAAWAARPGALTRLLLVELLAWQFASPVRWIETQDLFFGSTTYGGLGVTQLIEVGVGKSPTLANLASQTLKVPSVRVRLDRAVDVYNLERDAARCFSTDEDVVIDDDEPEAAAPADSAPAAAAPVAAAPAAASANIADLPFTAADATRLLLTWWTKIRADQLAGNDSIEALTDGASSRRNQLLVDLGTELSLGAIDGAAEADLGTLSGQVNALARGYKPFGPVLSVTLADHLKKVLGPAGVRQSAIADRVTGHWQLGAGWAHHVLVEVALRTREGASVRGGDLAAGAAPGNAGEATAIIDAAVTAVAARHGVSVAAPVAESASVDAGALAGITGGITDALVSTAKHLLAKFEPAAVATAEDANDDAALIAHVERELGTGWITATAPAFDAKRAVLLDDRWASVREDIVRIAYGEQDSANIDAAGDNAAAIARWLELDDVASAAETTQVGTWAEDTAIITGASVGSIAAAVAGELLAGGATVIATTSRLDDARLAFFKQLYREHAQVGAKLWVVPANMASFADIDAFVAWVTGEQTTAVGPTTKVTKPALRPTLLLPFAAGSVRGDAADVGPRAEVEARILLWSVERLVTADWGRSLHVVLPGSPNRGRFGGDGAYGEAKAALDALVTRWKAERDWAENVTLAHAIIGWVRGTGLMKSNDPLVEAVEAAGVRTWSNAEMAAELLALCSVAAREKAAVEPLTVDLTGGLDAINLRELAKSVADSASADDEVAAETVSRIDALPGSPADLHEPHIPEWPTLEVRPEDLVVIVGAGELGPYGSSRTRFEVEVSGELSAAGVLELAWTTGLVRWDAVAGSWFDVASDEAVDEAEIFDRYNDAVLERCGVRDYVEDGAITPGSAPLLASVFLPEDLTFTVSSEAEAQAMREANPEHTAIATNADGEWTVTRRAGTEIRVPRRVSVSRTVGGQLPTGFDPRVWGIPGEMVEAIDRVALWNLVCTVDAFLSSGFTPSELMRWVHPARVANTQGTGMGGMTSMQSLYVDTLLGESTANDLLQEALPNVIAAHVMQSYVGGYGAMVHPVAACATTAVSVEEGVDKIRVGKADVVVAGGFDDLSTEGVVGFAAMSATADTEAMRAQGISDRYISRANDRRRGGFVESQGGGTLLLARGDVAARMGLPVLGVVAYAGSYADGIHTSIPAPGLGALSAGLGGQDSMLAKALNGLGLTADDVAVISKHDTSTAANDPNESELHERLADALGRHADNPLLVVSQKSLTGHAKGGAAAFQLIGLCQVLTQGVVPPNRSLDCLDPALEEYRRLVWLRQPLHTGPLRAGLVTSLGFGHVSGLVAVVHPEAFIQSLPADEREDYRARARARQVDGRLRITRAMLDEPAYVRPKGRRLGDAAGYREREAEVLINPTARLAQDGAYACR
>AP019307.1|BBH17880.1|2190854_2191367_-|hypothetical-protein
MPLTAFSPEAIDGHVVGVGLDVVDVASFAEQLALPGSRFSTFFRTGERAEIAARGGGAEHWAARWAAKEALIKAWSTLFYGRPPILADDSLGLVEVVSDGWGRPRLATHGALRLELSDYEIQVSLSHDGPIAAAYVVLSAACRYAPSSRLSSVTASACSCPSRTEKLSIE
>AP019307.1|BBH17879.1|2190345_2190966_+|TetR-family-transcriptional-regulator
MTEELLEPRRRPTQDRSQKKFDELLRVARRLLIDVGFESFTCEEVAHRAGLPIGTLYQFFANKYVIVCELDRQDAVDVREQVRELTAQLPTLDWPALVNQVVDRMAAMWVADPSRRAVWHAVQSTPATRATATVIERDLAASVARTLAPLTPGTPRERRTIIAEVLVHVVYSMLNFSVRDGQEHAEAVTELKRLLGAYLHAAESTT
>AP019307.1|BBH17878.1|2188707_2190207_-|methylmalonyl-CoA-carboxyltransferase
MTQQLTAPADLDDFNEDPQRAALLTRRAAKAVRVAPRGNRTFTAKERAEQLADQGTFVAFAPARSREPGVGAGVLTGWATVNRRPVVIISHDAAVAAGAIGAVFADAVQDAQRFAIDHGYPIIYLNDSSGARIHDGIHALHGCGGIFRLNVKATRRVPQISVILGPCAGAAAYSPALTDWTIMVREQGQMFLTGPDIVKAATGEDATAEAIGGADMHTQTSGVAHLAVDSEAEAIQATRKILSFTPTYAGGPLPESLPVGPDAAAAAELPYVVPSKASVGFDMTQVIAGVVDEGSMFEIMPTRSPSVLTMFARLDGKPVGILANQPNARGGILDTQTSVKASRFVDYCGRFGIPVLTFVDVPGFLPGTVEEGRGVITYGATLLRAYAEATGPLLTVIVRKAYGGAYIAMGSPSLGADACWAWPGSEIAVMGPGGAVALLNRRELAAAEDPAALRDSLAADYRENVARPWIAAEAGIVDDVILPEETRDRLVASLRMLTA
>AP019307.1|BBH17877.1|2188453_2188711_-|hypothetical-protein
MSDTVPHVAPIVASVWKIEVAVGDHVEAGSMLAVVESMKMEIPIFATVAGVVASIPVEPGQIVQEGDAVVVIVPGAGVPQPRAAG
>AP019307.1|BBH17876.1|2187764_2188415_-|hypothetical-protein
MQIHRFTEPVATFLERPIPSGLSEAEAWFFEAPGPVLVMGSAQDVALAEAAPGMDVARRRSGGGAVFVDPARSLWLDVIVPPTDPRWSDDVRTSSHWLGRAWAEALRSIGIEGEVYDEGLEKTPWGRLVCFGANGPGEVLIAGRKTVGIAQRRTRDGARFQCIVYDRWDPHDVVDHLVLTEVERAAISADLAEVAGGVGDRLGELRDAITRRLLVD
>AP019307.1|BBH17875.1|2186843_2187746_-|LysR-family-transcriptional-regulator
MFVEIDTIRSFLAVADGRTVTEAAELANRTQPAMSRALARLEREAGSELFQRVGRGVVLTPAGHELVPYARSIVEAYDRGVRAVQDMAAPDGGFVPVAFLHTLGTWLVPELVQQFRRERPDVRFDLRQHGDAGLVDDLLSGVVDMAITGDRPTHPQIESIRLLEEPLRLVVPPNHRLAERKSVRLKEAAGETFIALKPGFSLRDVTTTLCAQAGFEPTFGFEGEEVDTIRGLVAAGLGVALLPAPHSGGAPTAPHLQISDVKAVREIGLAWMKDRRLPPASEHFRTHVAAHAREALAARS
>AP019307.1|BBH17885.1|2203085_2203484_+|cold-shock-protein
MPTGKVKWFDVEKGFGFLSQDGGQDVYVHADALPAGTAATLKAGTRVEFGIAQGRRGDQALQVRLLEAPTSVTRNQAAARRRKPEEMVLITENVIKLLDGIREGYEHDRSPSRDIAKKVAPALRALADEFEL
>AP019307.1|BBH17886.1|2203539_2204907_-|MFS-transporter
MSWQAPPPPYGDPPPPLEQEARRRRRGAAVARGLGRTGVWAARTARRAADAQGADVSGLNRLLEVHAVNAAADAAVAISLAGSLFATPATGGHGGRGSVALYLLLTMLPFAVVAPLLGPFLDRFAHGRRWAIGGSMAARAFLCWVLSTALPHQTVWMFPAALGILVMSKAYGVTKAAAVPRLIPAGFTLVKTNGRVSMAGMVGVAVSAPMAGLMSLIGAEWVLRWGFLLFVLATIAAIRLPAQVDHSAGEEGSHLRGLEGGRLRIPPPVTYALRANCAPKWTSGFMLMFMSFYLQKYPLPGLSILMSLGLLAGAAGLGNLIGVTAASLLRNVPPRLTVSVVVVADAVVAIIAAIAFNTWTVIAFALVAGLGQSLAKFALDSTIQQHIPAHIQTSAFARAETALQLAWVVGGFVGIALPLTHNAHIGFWTAGVVLSGWGAYVLSRRTATPAPVLPT
>AP019307.1|BBH17887.1|2204905_2205757_+|hypothetical-protein
MRYILPRADTSGSHAPCRTDISSPMVDHGAVTSTTSPTDAAAIDAARAALVEEAGIPDIGEHLDAVAEDTGAVTHRFASLRAGYVGWAWSVTINQLPDAAITIDEIVLMPGEGAITAPAWVPYRDRIKPGDLSPGDLLPVADDDPRLVPTYSFGDDPLDQDARGQIRAVGKDLGLGRVRTLGQEGFDDVAERWYDGQGGPDSALAQAAPDQCHSCGFLVRLNGPLGLTFGVCANGDANDDGRAVSLNHGCGAHSEVRLAKRHEAQPLPPPVWDTLTPDDLDRL
>AP019307.1|BBH17888.1|2205728_2205965_-|hypothetical-protein
MAVEPRPIDPFGVRAVQIGTAAFAVACLGLLPFWGRLQTDGHLWWVWTCLVGTGLGLVGIDICRRRQDRTTDDPGRPE
>AP019307.1|BBH17889.1|2206041_2206470_+|putative-HTH-type-transcriptional-regulator
MTLANAELAAGLRVAVMRLRRRLANEHDPEHDLSIGSMAVLGGLYRHGELTLGELAERERVRPPSMTRTIKCLAEGGYVTRSSGEYDRRQVVIALTDLGRSAVIADRRRRDAWLSERLGELTVQERDVLRAAAPILEKLAEA
>AP019307.1|BBH17890.1|2206466_2207708_+|MFS-transporter
MSPTFRALHNPNYRLYLAGSVVSNTGTWMMRVAQDWLVLQPLHGGSAAVGITTGLQFLPILLLTPYAGVVADRVPKRRLLQITQATMGAASLISGAVAVSGHSALWIVYLCALGLGVGAAFDAPARQSFVSEMVEVEDLTNAVGLNSASFNVARLMGPAAAGLLIAALGSGQRATGVVFLVNAASYAAVILQLRRMDPTLLHPADRRARGPHDLLEAVAYVRSQPRMLFVLIVIFFVGTFGMNFQLTSALMATQVYGKGAGEFGLLGSALAVGSLTGALMAARRTSIRLRLLVLGALGFGAAEVVAAFLPSYGLFALCCPLIGFSALTVANTANSTLQLSADPAYRGRVMALYMTVFQGGTPLGAPLIGWIGQAYGARWTLIVGGALVLVGAGIASTAYAAAAQRSRTPVAAF
>AP019307.1|BBH17891.1|2207887_2208262_+|30S-ribosomal-protein-S12
MPTINQLVRKGREDKASKTKTPALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLSSGVEVTAYIPGVGHNLQEHSIVLVRGGRVKDLPGVRYKIIRGTLDTQGVKNRKQARSRYGAKKEKA
>AP019307.1|BBH17892.1|2208261_2208732_+|30S-ribosomal-protein-S7
MPRKGPAPKRPIDVDPVYGSQVVTQLVSKVLKDGKKQVAQRIVYTALEGTRDKTGADPVITLKRALENVKPAIEVKSRRVGGATYQVPVEVKGTRGNTLALRWLVGYAADRREKTMAERLMNEILDASNGLGAAVKKREDTHKMAESNKAFAHYRW
>AP019307.1|BBH17893.1|2208805_2210920_+|elongation-factor-G
MAVDITTDLSAVRNIGIMAHIDAGKTTTTERILFYTGISYKIGEVHEGAATMDWMEQEQERGITITSAATTCWWKKHQINIIDTPGHVDFTVEVERSLRVLDGAVAVFDGVAGVEPQSMTVWRQANKYKVPRMCFVNKLDRTGGDFYRVLDTIVAKLNSTPLVLQLPIGAEADFIGIVDLVEMNAKVWRGETQQGEDYVVEEIPADLADKAVEWREKLVETLAEADDAIMEVYLEEGDVFDVPTLKAAIRRATIADKLNPILCGTAFKNKGVQPLLDAVIDYLPSPLDVDSIVGHKPNNDEIEIERQPSDDEPLSALAFKIATDPHLGKLIYVRVYSGKLAAGATVLNATNGRKERIGKVYQMHANKREEIASVGAGQIVAVMGLKDTKTGHTLSDPTNPVVLESMTFPAPVIEVAIEPKTKSDQEKLGTAIQRLSEEDPTFVVKTDEETGQTIIAGMGELHLEILVDRMRREFKVEATVGKPQVAYRETIRGTVTGHSYTHKKQTGGTGQFAKVLVNLEPNINPETGQGAGYEFVNTVTGGRVPREYIPSVDAGAQDAMQFGILAGYPMVDVKFTLTDGGYHDVDSSELAFKIAGNQAFKEAARMAKPVLLEPVFAVEVTTPEDYLGTVIGDINSRRGQIRAQEERHGDLVVSALVPLSEMFGYVGDLRSKTSGQASYSMEFDSYAEVPTNVADEIIKKARGE
>AP019307.1|BBH17894.1|2210988_2212182_+|elongation-factor-Tu-1
MAKAKFERTKPHVNIGTIGHIDHGKTTLTAAITKVLHDAYPDLNEASAFDQIDKAPEERQRGITISIAHVEYQTEGRHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPSLVVALNKCDMVDDEELIELVEMEVRELLSEYEFPGDDIPVVRVAAFPALQGDAKWGESVLELMKAVDDYIPTPARETEKPFLMPVEDVFTITGRGTVITGRIERGIVKVGEEVEIVGIRETSQKSTVTGVEMFRKLLDEGQAGENVGLLLRGTKREDVERGMVVIKPGTTTPHTEFEANVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTEMSVQLIQPIAMDEGLRFAIREGGRTVGAGRVTKINK

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Crispr_ID: AP019307_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP019307_3

2313468-2313544

Unclear

Consensus_repeat	Method
ATCTGACAGACATGTCTGTCAGATT	CRISPRCasFinder

1 spacers

The CRISPR arrays of AP019307_3

>merge|AP019307|3|2313468-2313544|CRISPRCasFinder
ATCTGACAGACATGTCTGTCAGATTGAGTTGTGCCTCGCTGGGGCGACAGAGGATTGACAGACATGTCTGTCAGATT

>AP019307|3|3|2313468-2313544|CRISPRCasFinder
ATCTGACAGACATGTCTGTCAGATT	GAGTTGTGCCTCGCTGGGGCGACAGAG
GATTGACAGACATGTCTGTCAGATT

Protein	Signature genes	Signature genes Name	Protein_function
AP019307.1\|BBH18003.1\|2315311_2316277_+\|deacylase	unknown	unknown	gnl\|CDD\|349469
AP019307.1\|BBH17998.1\|2310559_2311477_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|185693
AP019307.1\|BBH18010.1\|2321186_2321771_+\|hypothetical-protein	unknown	unknown	unknown
AP019307.1\|BBH17995.1\|2307904_2308651_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226730
AP019307.1\|BBH17992.1\|2307095_2307476_-\|UPF0225-protein	unknown	unknown	gnl\|CDD\|225557
AP019307.1\|BBH18002.1\|2314827_2315322_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226553
AP019307.1\|BBH17993.1\|2307472_2307700_-\|UPF0235-protein	unknown	unknown	gnl\|CDD\|376843
AP019307.1\|BBH18006.1\|2318921_2319431_+\|transcription-elongation-factor-GreA	unknown	unknown	gnl\|CDD\|234693
AP019307.1\|BBH17994.1\|2307722_2307908_-\|hypothetical-protein	unknown	unknown	unknown
AP019307.1\|BBH18004.1\|2316287_2317586_+\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
AP019307.1\|BBH17996.1\|2308703_2309330_-\|TetR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|236928
AP019307.1\|BBH18005.1\|2317572_2318781_+\|threonine-ammonia-lyase	unknown	unknown	gnl\|CDD\|236182
AP019307.1\|BBH18008.1\|2320014_2320896_+\|mycothiol-S-conjugate-amidase	unknown	unknown	gnl\|CDD\|132487
AP019307.1\|BBH18009.1\|2320900_2321149_+\|hypothetical-protein	unknown	unknown	unknown
AP019307.1\|BBH18001.1\|2313591_2314842_-\|putative-alpha-L-glutamate-ligase	unknown	unknown	gnl\|CDD\|182468
AP019307.1\|BBH18007.1\|2319432_2319783_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379491
AP019307.1\|BBH17991.1\|2305716_2307102_+\|cystathionine-beta-synthase	unknown	unknown	gnl\|CDD\|273464
AP019307.1\|BBH17997.1\|2309360_2310548_+\|cytochrome-P450	unknown	unknown	gnl\|CDD\|225035
AP019307.1\|BBH18000.1\|2312284_2313439_+\|cystathionine-gamma-synthase	unknown	unknown	gnl\|CDD\|236104
AP019307.1\|BBH17999.1\|2311542_2312202_-\|peptide-methionine-sulfoxide-reductase-MsrA	unknown	unknown	gnl\|CDD\|234604

Protein	Function_ID	Function_description	E-value
AP019307.1\|BBH18003.1\|2315311_2316277_+\|deacylase	gnl\|CDD\|349469	cd06251, M14_ASTE_ASPA-like, Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup. A functionally uncharacterized subgroup of the Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily which is part of the M14 family of metallocarboxypeptidases. ASTE catalyzes the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway, and aspartoacylase (ASPA, also known as aminoacylase 2, and ACY-2; EC:3.5.1.15) cleaves N-acetyl L-aspartic acid (NAA) into aspartate and acetate. NAA is abundant in the brain, and hydrolysis of NAA by ASPA may help maintain white matter. ASPA is an NAA scavenger in other tissues. Mutations in the gene encoding ASPA cause Canavan disease (CD), a fatal progressive neurodegenerative disorder involving dysmyelination and spongiform degeneration of white matter in children. This enzyme binds zinc which is necessary for activity. Measurement of elevated NAA levels in urine is used in the diagnosis of CD.	2.63533e-88
AP019307.1\|BBH17998.1\|2310559_2311477_-\|hypothetical-protein	gnl\|CDD\|185693	cd08023, GH16_laminarinase_like, Laminarinase, member of the glycosyl hydrolase family 16. Laminarinase, also known as glucan endo-1,3-beta-D-glucosidase, is a glycosyl hydrolase family 16 member that hydrolyzes 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans such as laminarins, curdlans, paramylons, and pachymans, with very limited action on mixed-link (1,3-1,4-)-beta-D-glucans.	1.48337e-25
AP019307.1\|BBH17995.1\|2307904_2308651_-\|hypothetical-protein	gnl\|CDD\|226730	COG4280, COG4280, Predicted membrane protein [Function unknown].	5.01196e-44
AP019307.1\|BBH17992.1\|2307095_2307476_-\|UPF0225-protein	gnl\|CDD\|225557	COG3012, COG3012, Uncharacterized protein conserved in bacteria [Function unknown].	1.35192e-34
AP019307.1\|BBH18002.1\|2314827_2315322_+\|hypothetical-protein	gnl\|CDD\|226553	COG4067, COG4067, Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones].	1.04987e-40
AP019307.1\|BBH17993.1\|2307472_2307700_-\|UPF0235-protein	gnl\|CDD\|376843	pfam02594, DUF167, Uncharacterized ACR, YggU family COG1872.	4.83913e-21
AP019307.1\|BBH18006.1\|2318921_2319431_+\|transcription-elongation-factor-GreA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	4.23726e-37
AP019307.1\|BBH18004.1\|2316287_2317586_+\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	4.19653e-50
AP019307.1\|BBH17996.1\|2308703_2309330_-\|TetR-family-transcriptional-regulator	gnl\|CDD\|236928	PRK11552, PRK11552, putative DNA-binding transcriptional regulator; Provisional.	2.71343e-05
AP019307.1\|BBH18005.1\|2317572_2318781_+\|threonine-ammonia-lyase	gnl\|CDD\|236182	PRK08198, PRK08198, threonine dehydratase; Provisional.	0
AP019307.1\|BBH18008.1\|2320014_2320896_+\|mycothiol-S-conjugate-amidase	gnl\|CDD\|132487	TIGR03446, mycothiol_Mca, mycothiol conjugate amidase Mca. Mycobacterium tuberculosis, Corynebacterium glutamicum, and related species use the thiol mycothiol in place of glutathione. This enzyme, homologous to the (dispensible) MshB enzyme of mycothiol biosynthesis, is described as an amidase that acts on conjugates to mycothiol. It is a detoxification enzyme. [Cellular processes, Detoxification].	3.84304e-160
AP019307.1\|BBH18001.1\|2313591_2314842_-\|putative-alpha-L-glutamate-ligase	gnl\|CDD\|182468	PRK10446, PRK10446, 30S ribosomal protein S6--L-glutamate ligase.	5.95723e-100
AP019307.1\|BBH18007.1\|2319432_2319783_-\|hypothetical-protein	gnl\|CDD\|379491	pfam14155, DUF4307, Domain of unknown function (DUF4307). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	8.76519e-10
AP019307.1\|BBH17991.1\|2305716_2307102_+\|cystathionine-beta-synthase	gnl\|CDD\|273464	TIGR01137, Cystathionine_beta-synthase, cystathionine beta-synthase. Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family].	0
AP019307.1\|BBH17997.1\|2309360_2310548_+\|cytochrome-P450	gnl\|CDD\|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	1.39777e-89
AP019307.1\|BBH18000.1\|2312284_2313439_+\|cystathionine-gamma-synthase	gnl\|CDD\|236104	PRK07811, PRK07811, cystathionine gamma-synthase; Provisional.	0
AP019307.1\|BBH17999.1\|2311542_2312202_-\|peptide-methionine-sulfoxide-reductase-MsrA	gnl\|CDD\|234604	PRK00058, PRK00058, peptide-methionine (S)-S-oxide reductase MsrA.	2.00624e-115

>AP019307.1|BBH18000.1|2312284_2313439_+|cystathionine-gamma-synthase
MTDPDASLAFETRAIHAGYDPDPTTGAVIPPIYATSTYKQDGVGGLRNGYEYSRSANPTRTALEGALAALEGGAHGLAFASGLAAEDAILRALLRPGDHLVFPNDAYGGTFRLVDKVFKPWGLAYTPVPVTDLAAIEAAITPATKLIWLETPTNPLLNVADIAAVAALAKSHGVLVVVDNTFASPYLQQPLSLGADIVVHSTTKYLGGHSDVVGGAVVTDSDDLAEKVRFHQNASGGVPGPFDSFLTHRGLKTLAVRMDRHCDNAEAIAAHLSTHPAVSQVIYPGLASHSSHEVAARQMRRFGGMISVRLRGGEPAALDAVARAKIFTLAESLGGVESLIEHPARMTHASVAGTDLEVPADLIRLSVGIENVADLIADLDQALA
>AP019307.1|BBH17999.1|2311542_2312202_-|peptide-methionine-sulfoxide-reductase-MsrA
MFGRSSWINKSELIPEDRTLAGRTQALPLSASHRVLGVDLLADPDNGTAPAGFELAYFGLGCFWGAEELFWQVPGVFTTAVGYQGGTTPNPTYEEVCSGQTNHTEAVRVVFDPERVTYADLVKKFFEVHDPTQGFRQGNDVGTQYRSALYVNSPEQEAVARDLTAAYGAELARRGYGTITTEIRPVPTFYPAEAYHQQYLDRVPNGYRCHANTGVPFPG
>AP019307.1|BBH17998.1|2310559_2311477_-|hypothetical-protein
MTDAPRDPETGSGGGAFVRMLRSAPALVAIGVMLTTGAVFSGRLDHHAAPTCLPDEFADGQRWICTFHDEFDGQALDRTKWFVQTGFVTGNPNTAAYACTVDDPKYISVSGGELHLTMDRVPNPVPCTGYADSTYESPSISTYHTFSQQYGRIEVRSRVTATPAPGLQESLWLWPDDRYVAKADQAKGEIDISEQYSLYPELAVPFLHGKRGGNPVPGVNTAWACAAARGVWNTFVFVSTPTSITISVNGKTCLHNTDGDPAFHQRYIMVLTQALGVTNNAPTPKTTIPATTDIDYVRMWKSATN
>AP019307.1|BBH17997.1|2309360_2310548_+|cytochrome-P450
MAITFEPMDTDFQRDPYPAYTWLRQHDPVHRHAATRETPEYWALSRFEDIWDAVRRPEDFSSAEGLTFFPDEIGQLGLAPTIVMLDPPRQTQLRGLIGRGFTPRRIAELEDVIRAFVRARVEVLRDSGTDLHQDFSSTIPTFVLAELFGVPREDRTRFGPWVRELTNLQNDPLGLAVHDGTAVIVEMFEYFTAAIADRRRTPQDDLLGALVEAEIDGDRLTDWDILGFCFVMVAGGSDTTASLISHGVALLTEAPDQRALLVEDRSLIPDALMEFLRLESSVQGLCRTTTRDVSVAGTTIPSGQKVLMLYGSANRDEAEFGETVDLLDVRRAPKRHLAFSSGPHFCIGNHLARLQARVAFEELLAAMPDIAVDGPAGVRQRSAFVRGWESLPLVR
>AP019307.1|BBH17996.1|2308703_2309330_-|TetR-family-transcriptional-regulator
MLVLITMARDATTTRERLLRAGEQRFARDGVAGAKLRDIVREAGQANDSAVGYHFGSRQGLLGAIAQRHVAAMDAARAEPRPDMSVLDLVDELVRPTADLLQTPEGRDFLRITEQLAGWAGLDREHLAGTIQDTVLGRQLRALEDALTPPLGRGVARARTAEFALFVTASLAQRARVLESGTRPPRSHEAYVRDLVAMLAAAVSAPGP
>AP019307.1|BBH17995.1|2307904_2308651_-|hypothetical-protein
MTTYALVIAVLLACVVEAVEAVTIILAAGTARDWRSSLQGTAVGLLLLAAVCAILGPSVNQIPLNPLRLFVGTILLIFGLQWLRKAILRASGYKALHDEDAIFRRELAEARAAQTITRGAIADWYSFVLCFKAVVLEGLEVVLIVVTFGANQHRLGVAALAGAAGVILVAIAGVAVRAPLSRVPENTMKFAVGIMLTAYGAFWGAEGAHASWPGDDASLLWLIPAIAGFALVLVIGLRTIRARQEVTA
>AP019307.1|BBH17994.1|2307722_2307908_-|hypothetical-protein
MKVLRFFYDFFVGDDWQVAVAVVLGMAATWYLAHHGSSAWFVVPIVLLLALPYTLWRAIRK
>AP019307.1|BBH17993.1|2307472_2307700_-|UPF0235-protein
MTRYGITVKPGSKKGPLVEASADGSLTIYVRERAVDGAANDGVIRLLADHFGVPRSRIDIVRGHTSRSKLIAVDE
>AP019307.1|BBH17992.1|2307095_2307476_-|UPF0225-protein
MIATCPCGSGLRYDLCCGRLHRGAALAQTPEELMRSRYSAYALGAFDPELLNYVLATWHPRTRPESIEGGGLTWTGLEVHGHGDDWVEFSAHYRAADGTFGTMTERSLFERRAGRWFYVVGDVEDQ
>AP019307.1|BBH17991.1|2305716_2307102_+|cystathionine-beta-synthase
MEYVDSILDLIGNTPLVRLNRALDGLEDGPIVLAKVEYLNPGGSVKDRIASRMIEAAEASGALKPGGAIVEPTSGNTGVGLALEAQRRGYKCVFVCPDKVSEDKRNVLKAYGAEVVVCPTAVPPEHPDSYYNVSDRLASQPGAWKPDQYSNPHNPRSHYETTGPEIWQQTEGKVTHFVAGVGTGGTISGIGRYLKEQNPDVQIIGADPEGSVYSGGTGRPYLVEGVGEDFWPETYDRTVADRIIEVVDADSFAYTRRLAREEGLLVGGSSGMAAYAARQLAHELSRSGRTDAVIVVLLPDSGRGYLTKVFNDAWLSQYGFATGSEASSQTVGEVLRGKDGRLPDLVHTHPAETVAEAVHILREYGVSQMPVVRAEPPIVAAEVAGSVSERTLLEALFTGQAKLTDLVEKHMSAPLPSIGSTEPATAAAQVLETSDALLVHEDGKPVGVLTRADLLATLATH
>AP019307.1|BBH18001.1|2313591_2314842_-|putative-alpha-L-glutamate-ligase
MECRHTHIQSGTCHSFPEALLKLAILSRAPRCYSTQRLRSAALDRGHDVKVLNTLRFGIDLSGPEPDLTFRGKQLSHYDAIIPRIGNSITYFGTAVVRQFEQMDVYTPNTANGIANSRDKLRASQILSRHGIGMPATTFVRDRADVVPAIQRVGGAPVVIKLLEGTQGIGVILAPSVKVAEAIIETLQSTKQNVLIQSFVKESKGRDIRALVVGDRVVAAMRRSAQGDEFRSNVHRGGLVEPVELTEEYQRVAIRAAQIMGLKVAGVDMLEGTDGPLVMEVNSSPGLQGIEFATKLDVAGAIIDHMANQVAFPQIDVRERLSVSTGYGIAELVVRGDASLVGKSLGDSGLRERDITVLTLHRGSLVIPNPAARHVLEAEDRLLCWGKLEEMRSMIPDRRTRAKRVRKLPKTPILES
>AP019307.1|BBH18002.1|2314827_2315322_+|hypothetical-protein
MSALHSTTPGRLVVGWREWVGLPQIPVPWMKAKIDTGARTSALHAFGIEPFERDGAPWVRFSVHPWQRSALDTTGVERPVHDVRHVRSSSGHAQERYVVLLDLRILDQVVTAEVTLTHRDAMGFRMLIGREALRGRFVVDSARSYRGGRPEQETRDRNRGRHGA
>AP019307.1|BBH18003.1|2315311_2316277_+|deacylase
MGRESFAIGQVRVRPGSRKDVELPITRLVTGGDVSLPVQIVHGKYDGPTIWVSAAIHGEEVMGVEVVRRLLATLNPKHLHGTLMAVPVVNVLGFMTGDRYLPDRRDLNRAFPGSPRGSLASRIAHLFMEEVVSKCELGIDLHTAADRRANLPQLRGDLDDPRTYGLAKVFGAPVMLHAKLRDGSLRQAATEAGSMVLLYESGEAMRFDELSIGTGVAGIRRVMAHLGMIEEVVEQPAAPTLESRESNWIRARGTGIFQLECELGDMVESGRRLGRTSDTFGRGGRLVRADRDGIVIGLTRAPIVNAGDGLVHVAQITSTDG
>AP019307.1|BBH18004.1|2316287_2317586_+|AI-2E-family-transporter
MSSDGPQDHQPESVTEPASESAAEPAEETQRGRRENTERIALRVLNQLNQVRREREQEFAHAADGVLPRESRDRPRVPYGIDVASAWAWRLLLIVAAGWVLAKALGHLQVVVIPIVVALLISALVVPLVNLAERMRVPRSVGALLVVLVVVAIIASMLTFAGREVAAGASDLATQAAAGLDKLRSWLQTGPLHLTNNQIDGWLNSLQNALVHWSKDGNPVGKVTAVGSIALDVVAAMFIVLFSTYFFLAEGSRIWAWIVRLAPRSARTRLDSSGKVAWISLTQFVRATVIVAAVDAIGIMIGAAVLDVPFVAAIGVLVFLGAFVPILGATVAGTVAVLIAFVDHGIVTALIMLGWVVAVQQLEAHGLQPFLLGRWVRVHPLAVILSIATGVIVAGVAGALVAVPLAAATNAVALHLASLREDTDQVEPDAAV
>AP019307.1|BBH18005.1|2317572_2318781_+|threonine-ammonia-lyase
MRLSDVRDAAALLAGITRVTPVETSRWLSDRVGSPVLLKAENLQRTGSFKSRGAYVRLARLTVDERARGVVAASAGNHAQGVALASHLLGIRATVFMPAGVPTPKEHATRGYGADVVLQGADFQQTLAAAQEFAAETGAVFIHPFDHEDVILGQGTVGLEILDQVPDVRTVLVPTGGGGLLAGIGLAIKETRPEVRIVGVQAAGAASFPASLNAGQPRTLPNTQTMADGIAVARPGDLTLPLVEDYVDDIVTVSEESISHALLLTLERAKLLVEPAGAVGVAALLDDPSAFEGPVVVVLSGGNIDPRLLAKVIRHGLAAGGRYLGLDITLRDAPGALARLLQVVGEAGGNVLDVGHVRTNPLLLIDEVEVHLQLETRGEAHAASVVDAIRAEGFRAHPVAGV
>AP019307.1|BBH18006.1|2318921_2319431_+|transcription-elongation-factor-GreA
MTQSTDTQATHWLSAGAHEALTAQLADMRGPQLTKIVAEISAARDEGDLKENGGYHAAREAQGRLVGEADALEVLLRTSFTDAPVADGVVAPGVVVTYKFEGDDDDEAETFLLGAIEMKPFAHGLDVFSPAAPLGAALLGHTAGDTVSYTGPTGREIKVQIVSAKPFED
>AP019307.1|BBH18007.1|2319432_2319783_-|hypothetical-protein
MLLIVAAAALAAVGVWFVVTIGWVADAKVTSSIGGWTVNGEKSVTFTYTVTLGKNVNPADVRCEVTAQAKDFSSVGGPVTIVPPSGGTHSYTMRTSRHAVYVSWAGCSAPGQSNPR
>AP019307.1|BBH18008.1|2320014_2320896_+|mycothiol-S-conjugate-amidase
MSDRPLAGLRLMHVHAHPDDESSKGAASTAKYVAEGVDVHVATCTGGERGSILNPAMDRPGVLEDIAAIRSAEMDRAREILGITQDWLGFVDSGMPDDPADLPVGSFAVVPLEQPVEALVRLIRTFRPHVMTTYDERGGYPHPDHIRCHEVSMAAYAAASDPTQFPDAGEPWQVLKIYYQFTFSRARMAALHQAMLDRGLESPYAEWLSHPSDPAWDARVTTRVPCADYFDVRDAALLAHETQIDPHGFWFAVPREVQQEVWPTEDFQLVDSKVSTSIPEDDLFAGIPYPVAD
>AP019307.1|BBH18009.1|2320900_2321149_+|hypothetical-protein
MLYLLAATMDPAPADNDVVAGPWGFLIFFLLLVAVAFLGWSFRNQLRKTDAAAAAGLYDPSEPKKRVEIPVDTGAPADSTSE
>AP019307.1|BBH18010.1|2321186_2321771_+|hypothetical-protein
MLAVTLRLVKHSYLVGFGALALLASCMTPPTSSDPLPDAPSSSHASHAPARPSSTPVRGGSALTALAHLPVKGRAPKTGYSRAQFGEAWTDDNDEMWGRNGCDTRNDVLRRDLADVVLRSDGCKVATGTLRDPYTAKIISFVRGPGTSSLVQIDHSVSVVLTRAVLTFAGQDVSGMLPTGRRLDAARPVWGSGR

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2325125 : 2383616

Klosneuvirus(11.11%)

holin,protease,integrase,tRNA,transposase

attL 2318661:2318677|attR 2340570:2340586

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2318661:2318677	attL	NA	NA	NA	NA
BBH18015.1\|2325125_2326304_+\|integrase,transposase	putative transposase/integrase	S6C485	Thermus_phage	2.5e-08	36.9
BBH18016.1\|2326290_2328513_+\|integrase,transposase	putative transposase/phage integrase	NA	NA	NA	NA
BBH18017.1\|2328593_2328917_+	hypothetical protein	NA	NA	NA	NA
BBH18018.1\|2329183_2329669_+	hypothetical protein	NA	NA	NA	NA
BBH18019.1\|2329773_2330082_+	hypothetical protein	NA	NA	NA	NA
BBH18020.1\|2330116_2331145_+	hypothetical protein	K4JUR1	Caulobacter_phage	5.5e-52	41.6
BBH18021.1\|2331154_2331697_+	hypothetical protein	NA	NA	NA	NA
BBH18022.1\|2331701_2332682_+	hypothetical protein	NA	NA	NA	NA
BBH18023.1\|2332706_2334284_-\|holin	choline dehydrogenase	A0A1V0SI18	Klosneuvirus	2.3e-57	30.7
BBH18024.1\|2334482_2335259_+	putative short-chain dehydrogenase/reductase	NA	NA	NA	NA
BBH18025.1\|2335255_2336542_-	ABC transporter substrate-binding protein	NA	NA	NA	NA
BBH18026.1\|2336848_2338318_+	long-chain-fatty-acid--CoA ligase	A0A2H4PQM9	Staphylococcus_phage	2.1e-36	28.6
BBH18027.1\|2338319_2340176_+	hypothetical protein	NA	NA	NA	NA
BBH18028.1\|2340183_2341608_+	dehydrogenase	NA	NA	NA	NA
2340570:2340586	attR	NA	NA	NA	NA
BBH18029.1\|2341631_2343644_+	thioredoxin domain-containing protein	NA	NA	NA	NA
BBH18030.1\|2343640_2344267_-	DNA-binding protein	NA	NA	NA	NA
BBH18031.1\|2344462_2345209_+	isoprenyl transferase	R9W0U9	Flavobacterium_phage	2.5e-14	35.6
BBH18032.1\|2345589_2346918_+	ATP-binding protein	M4R2C8	Vibrio_phage	3.5e-43	30.8
BBH18033.1\|2347059_2347719_+	hypothetical protein	A0A2L1IVL5	Streptomyces_phage	7.4e-26	62.9
BBH18034.1\|2347744_2349535_-	aminopeptidase	A0A0P0IY26	Acinetobacter_phage	4.8e-27	27.1
BBH18035.1\|2349567_2350953_-	fumarate hydratase class II	NA	NA	NA	NA
BBH18036.1\|2350975_2351560_-\|protease	rhomboid family intramembrane serine protease	NA	NA	NA	NA
BBH18037.1\|2351640_2353326_-	fumarate hydratase class I	NA	NA	NA	NA
BBH18038.1\|2353335_2353998_-	hypothetical protein	NA	NA	NA	NA
BBH18039.1\|2354066_2355128_+	acid phosphatase	NA	NA	NA	NA
BBH18040.1\|2355132_2356488_+	bifunctional NAD(P)H-hydrate repair enzyme	NA	NA	NA	NA
BBH18041.1\|2356484_2357618_+	alanine racemase	A0A0P0YM39	Yellowstone_lake_mimivirus	2.6e-39	34.1
BBH18042.1\|2357614_2358658_+	lipase	NA	NA	NA	NA
BBH18043.1\|2358659_2359565_+	hypothetical protein	NA	NA	NA	NA
BBH18044.1\|2359641_2360271_+\|tRNA	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	NA	NA	NA	NA
BBH18045.1\|2360267_2360699_+	hypothetical protein	NA	NA	NA	NA
BBH18046.1\|2360695_2361739_+\|tRNA	tRNA N6-adenosine threonylcarbamoyltransferase	A0A0R6PI74	Moraxella_phage	5.7e-57	41.9
BBH18047.1\|2361882_2362740_+	hypothetical protein	NA	NA	NA	NA
BBH18048.1\|2362778_2363960_-	methyltransferase	NA	NA	NA	NA
BBH18049.1\|2364159_2364453_+	10 kDa chaperonin	A0A221S4M3	uncultured_virus	3.5e-20	51.6
BBH18050.1\|2364452_2366078_+	60 kDa chaperonin 1	A0A240F779	uncultured_virus	3.2e-155	56.1
BBH18051.1\|2366161_2367037_+	hypothetical protein	NA	NA	NA	NA
BBH18052.1\|2367046_2368573_+	inosine-5'-monophosphate dehydrogenase	A0A1V0SHK8	Klosneuvirus	1.1e-93	40.5
BBH18053.1\|2368684_2369086_-	hypothetical protein	A0A1P8DIZ8	Virus_Rctr197k	6.1e-15	37.9
BBH18054.1\|2369303_2369957_-	TetR family transcriptional regulator	NA	NA	NA	NA
BBH18055.1\|2370079_2370979_+	lipase	NA	NA	NA	NA
BBH18056.1\|2370983_2371751_+	short-chain dehydrogenase	A0A0K0KVL6	Prochlorococcus_phage	8.1e-08	26.6
BBH18057.1\|2371756_2372233_+	hypothetical protein	NA	NA	NA	NA
BBH18058.1\|2372229_2373450_+	hypothetical protein	NA	NA	NA	NA
BBH18059.1\|2373480_2374284_-	hypothetical protein	NA	NA	NA	NA
BBH18060.1\|2374280_2375186_-	ABC transporter	A0A2H4PQG7	Staphylococcus_phage	7.5e-29	36.1
BBH18061.1\|2375354_2376530_+	two-component sensor histidine kinase	NA	NA	NA	NA
BBH18062.1\|2376537_2377191_+	DNA-binding response regulator	NA	NA	NA	NA
BBH18063.1\|2377489_2378851_+	trigger factor	NA	NA	NA	NA
BBH18064.1\|2378968_2380099_+	hypothetical protein	NA	NA	NA	NA
BBH18065.1\|2380099_2381311_+	hypothetical protein	NA	NA	NA	NA
BBH18066.1\|2381351_2382326_+	putative metal ion transporter YfjQ	NA	NA	NA	NA
BBH18067.1\|2382427_2383000_+\|protease	ATP-dependent Clp protease proteolytic subunit	A0A248SJ97	Salicola_phage	1.5e-30	42.8
BBH18068.1\|2383010_2383616_+\|protease	ATP-dependent Clp protease proteolytic subunit 2	A0A223W000	Agrobacterium_phage	8.5e-37	44.1

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. AP019307

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection