CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP029618	Streptomyces sp. WAC 06738 chromosome, complete genome	5 crisprs	WYL,cas4,DEDDh,csa3,Cas14u_CAS-V,cas3,c2c9_V-U4,DinG	1	2	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP029618_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP029618_1

2310851-2310945

Orphan

Consensus_repeat	Method
GGTGCCCTGCGGGCGGCGCGGCGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP029618_1

>merge|CP029618|1|2310851-2310945|CRISPRCasFinder
GGTGCCCTGCGGGCGGCGCGGCGGGGTGGCGGGTGACGGTGCAAGCCGGACCCGCCACCCTACCCGGCGCCGGCGCCCTGCGGGCGGCGCGGCGG

>CP029618|1|1|2310851-2310945|CRISPRCasFinder
GGTGCCCTGCGGGCGGCGCGGCGG	GGTGGCGGGTGACGGTGCAAGCCGGACCCGCCACCCTACCCGGCGCC
GGCGCCCTGCGGGCGGCGCGGCGG

Protein	Signature genes	Signature genes Name	Protein_function
CP029618.1\|AZM46068.1\|2322007_2322817_-\|DNA-glycosylase	unknown	unknown	gnl\|CDD\|223344
CP029618.1\|AZM46057.1\|2303809_2306428_-\|valine--tRNA-ligase	unknown	unknown	gnl\|CDD\|235582
CP029618.1\|AZM46070.1\|2323378_2323996_-\|biotin-transporter-BioY	unknown	unknown	gnl\|CDD\|376871
CP029618.1\|AZM46069.1\|2322868_2323354_-\|ribose-5-phosphate-isomerase	unknown	unknown	gnl\|CDD\|235509
CP029618.1\|AZM46062.1\|2313734_2313929_-\|hypothetical-protein	unknown	unknown	unknown
CP029618.1\|AZM46063.1\|2314551_2315691_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|226122
CP029618.1\|AZM46059.1\|2307805_2309098_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	unknown	unknown	gnl\|CDD\|235422
CP029618.1\|AZM46061.1\|2311652_2313062_-\|trigger-factor	unknown	unknown	gnl\|CDD\|234956
CP029618.1\|AZM46053.1\|2298787_2299807_-\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237562
CP029618.1\|AZM50675.1\|2310086_2310689_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
CP029618.1\|AZM46060.1\|2309314_2310007_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|237133
CP029618.1\|AZM46065.1\|2318349_2319159_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224059
CP029618.1\|AZM46055.1\|2300572_2300953_-\|DUF4233-domain-containing-protein	unknown	unknown	gnl\|CDD\|379420
CP029618.1\|AZM46067.1\|2320719_2321862_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369272
CP029618.1\|AZM46064.1\|2315806_2318353_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|223650
CP029618.1\|AZM46066.1\|2319459_2320653_+\|cation/H(+)-antiporter	unknown	unknown	gnl\|CDD\|223551
CP029618.1\|AZM46058.1\|2306591_2307698_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223065
CP029618.1\|AZM46054.1\|2300057_2300471_-\|nucleoside-diphosphate-kinase	unknown	unknown	gnl\|CDD\|179085
CP029618.1\|AZM50674.1\|2302779_2303760_+\|hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240644
CP029618.1\|AZM46056.1\|2301044_2302628_-\|dihydrofolate-synthase	unknown	unknown	gnl\|CDD\|223362

Protein	Function_ID	Function_description	E-value
CP029618.1\|AZM46068.1\|2322007_2322817_-\|DNA-glycosylase	gnl\|CDD\|223344	COG0266, Nei, Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair].	2.60318e-58
CP029618.1\|AZM46057.1\|2303809_2306428_-\|valine--tRNA-ligase	gnl\|CDD\|235582	PRK05729, valS, valyl-tRNA synthetase; Reviewed.	0
CP029618.1\|AZM46070.1\|2323378_2323996_-\|biotin-transporter-BioY	gnl\|CDD\|376871	pfam02632, BioY, BioY family. A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes.	1.44395e-30
CP029618.1\|AZM46069.1\|2322868_2323354_-\|ribose-5-phosphate-isomerase	gnl\|CDD\|235509	PRK05571, PRK05571, ribose-5-phosphate isomerase B; Provisional.	1.78276e-82
CP029618.1\|AZM46063.1\|2314551_2315691_+\|hypothetical-protein	gnl\|CDD\|226122	COG3594, NolL, Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism].	2.17663e-33
CP029618.1\|AZM46059.1\|2307805_2309098_-\|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX	gnl\|CDD\|235422	PRK05342, clpX, ATP-dependent Clp protease ATP-binding subunit ClpX.	0
CP029618.1\|AZM46061.1\|2311652_2313062_-\|trigger-factor	gnl\|CDD\|234956	PRK01490, tig, trigger factor; Provisional.	1.1016e-150
CP029618.1\|AZM46053.1\|2298787_2299807_-\|rod-shape-determining-protein	gnl\|CDD\|237562	PRK13927, PRK13927, rod shape-determining protein MreB; Provisional.	0
CP029618.1\|AZM50675.1\|2310086_2310689_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	9.22164e-119
CP029618.1\|AZM46060.1\|2309314_2310007_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|237133	PRK12553, PRK12553, ATP-dependent Clp protease proteolytic subunit; Reviewed.	7.3958e-120
CP029618.1\|AZM46065.1\|2318349_2319159_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224059	COG1136, SalX, ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms].	1.42189e-103
CP029618.1\|AZM46055.1\|2300572_2300953_-\|DUF4233-domain-containing-protein	gnl\|CDD\|379420	pfam14017, DUF4233, Protein of unknown function (DUF4233). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.	2.02648e-23
CP029618.1\|AZM46067.1\|2320719_2321862_-\|hypothetical-protein	gnl\|CDD\|369272	pfam07228, SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.	4.10901e-33
CP029618.1\|AZM46064.1\|2315806_2318353_-\|ABC-transporter-permease	gnl\|CDD\|223650	COG0577, SalY, ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms].	1.05139e-13
CP029618.1\|AZM46066.1\|2319459_2320653_+\|cation/H(+)-antiporter	gnl\|CDD\|223551	COG0475, KefB, Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism].	2.05466e-42
CP029618.1\|AZM46058.1\|2306591_2307698_+\|hypothetical-protein	gnl\|CDD\|223065	PHA03378, PHA03378, EBNA-3B; Provisional.	4.20162e-06
CP029618.1\|AZM46054.1\|2300057_2300471_-\|nucleoside-diphosphate-kinase	gnl\|CDD\|179085	PRK00668, ndk, mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated.	6.67711e-75
CP029618.1\|AZM50674.1\|2302779_2303760_+\|hydroxyacid-dehydrogenase	gnl\|CDD\|240644	cd12167, 2-Hacid_dh_8, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	1.58593e-133
CP029618.1\|AZM46056.1\|2301044_2302628_-\|dihydrofolate-synthase	gnl\|CDD\|223362	COG0285, FolC, Folylpolyglutamate synthase [Coenzyme metabolism].	2.53652e-133

>CP029618.1|AZM50675.1|2310086_2310689_-|ATP-dependent-Clp-protease-proteolytic-subunit
MLSGPGEPSFGGLGDQVYNRLLNERIIFLGQPVDDDIANKITAQLLLLAADPDKDINLYINSPGGSVTAGMAIYDTMQFIKNDIVTIALGLAASMGQFLLSAGTPGKRFALPNAEILIHQPSAGLAGSATDIKIHAEQLIRTKKKMAELTSLHTGQTVEQVTHDSDRDRWFSAEEAKEYGLIDEVMPSASGIPGGGGTGA
>CP029618.1|AZM46060.1|2309314_2310007_-|ATP-dependent-Clp-protease-proteolytic-subunit
MQNFPGRGLYDRMADEAADARRSLGAESRYVIPRFVERTSQGIREYDPYAKLFEERVIFLGVQIDDASANDVMAQLLCLESMDPDRDISVYINSPGGSFTALTAIYDTMQFVKPDIQTVCMGQAASAAAVLLAAGTEGKRMALPNARILIHQPYTETGRGQVSDLEIAAKEIFRMRNQLEEMLAKHSTTPIEKVRDDIERDKILTAEESLEYGLIDQIVSTRKLSAGIGG
>CP029618.1|AZM46059.1|2307805_2309098_-|ATP-dependent-Clp-protease-ATP-binding-subunit-ClpX
MARIGDGGDLLKCSFCGKSQKQVKKLIAGPGVYICDECIDLCNEIIEEELAESSEVRWEELPKPREIYEFLEGYVVGQEAAKKALSVAVYNHYKRVQAGENGAAAQNREDGIELSKSNILLLGPTGSGKTLLAQTLARMLNVPFAIADATALTEAGYVGEDVENILLKLIQAADYDVKKAETGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQIDTTNVLFIVGGAFAGLEKLIESRAGAKGIGFGATIRSKRELANEDPFQEVMPEDLVKYGMIPEFIGRLPVITSVHNLDRAALLKILVEPRNALVKQYQRLFELDGVELDFDRPALEAIADQAILRGTGARGLRAIMEEVLQSVMYEVPSRKDVARVVITEEAVHSNVNPTLVPRSRAAEPEQRHQESA
>CP029618.1|AZM46058.1|2306591_2307698_+|hypothetical-protein
MSHNQPPPPGPYGGGGQQPGPYGQPGPYGQPQQPQQPAQSPYAQPGQGGQPGQPGYGYPQQGGDQGYGQQQQQPGGYGQPGGYGQQQYGQQQAGPYGQQQPGYGQAPPPPPPGGGKNKTLFVVVGAVVAVALIAVAAFFLIGGDDDDDGKKDESKNSQNDGDKTDDGGDSGDDPPADDGKKYKLTTPETVASEYQKDDSAPGGELNSSDIDQLETIGVSNPKDVGAGYTAGTEATAKILQFQGVYGDISNPDMVLDAFFTYMAKEAAADPSAGGGDTAELVGSPEEVNPDGLEEGASMKCQYVKFSSDDSGAPVDSFNFPTCAWADSSTIGYIAMTDPTLIITGGETSIDEAATTTAEVRNDVRVPLG
>CP029618.1|AZM46057.1|2303809_2306428_-|valine--tRNA-ligase
MTDAKNPQSSAAELPTQYTPGEVETSLYEGWVERGYFAADAKSDKPPYAIVIPPPNVTGSLHLGHAFEHTLIDALTRRKRMQGYETLWQPGMDHAGIATQNVVERELAKEGLSRHDLGREAFVERVWKWKAESGGQIAGQMRRLGDGVDWSRDRFTMDEGLSRAVQTIFKRLFDDELIYRAERIINWCPRCLTAISDIEVEYQDDDGELVSIRYGEGEQSIVVATTRAETMLGDTAVAVHPDDERYRHLVGTEIVLPLTGRRIPVLADEHVDPEFGTGAVKVTPAHDPNDFEIGRRHDLPMLTIMDEHAVITAHGPFQGLDRLEARSAIVAALRADGRIVAEKRPYTHSVGHCSRCKTTIEPRLSMQWWVKVGPLAKAAGDAVRDGRVAIHPKEMESRYFGWVDHLNDWCISRQLWWGHRIPVWHGPDGELVCVGPDEEPPSGEGWTQDSDVLDTWFSSGLWPFSTLGWPEETESLAKFYPNSVMVTGYDILFFWVARMMMFGLYAMDGEIPFRTIVLHGMVRDEFGKKMSKTFGNVVNPLEWMDKYGADAVRFTLARGANPGTDVPIGEDWVQGSRNFANKVWNATRFALMNGATVEGPLPAEADLSTTDRWILSRLGAVVAEVDALYDDYQFAKLSDVLFHFAWDEVFDWYVELSKTTFAAGGPAADASRRVLGEVLDVTLRLLHPVVPFVTETLWTTLTGRESLVIADWPADSGFRDAAAEAEIVKLQEVVTEVRRFRADQGLQPGQRVPARVELSGAGLEEHEAAMRQLLRLQPEGGSFAATASLPVAGATVALDLSGTIDVAAERKRLTKDLAAAEKEKAQAEAKLGNEGFLAKAPEPVVAKIRTRLAKAEEDIVRIGAQLERLPQA
>CP029618.1|AZM50674.1|2302779_2303760_+|hydroxyacid-dehydrogenase
MSPDVLPRLFDAATRDRLAEVADLEPGLVAADFTVPRAAAALAGAEVLVTCWGCPPLDEAALAAAPELRAVVHAAGSVKHHVTEAVWRRGIAVSSAAWANALPVAEYTVAAVLFANKRVLEVREEYRRRRGPYDWYADHPGAGNYRRTVGIVGASMIGRRVLELLRPYDLSALVYDPYADDGELRALGATPAGLDELCATADVVSVHAPALPSTRHLISRARLASMRDGATLVNTARGSLVDQEALTEELVSGRLHAVVDVTEPEFLPAGSPLYELPNVLLTPHVAGSLAGELPRLGRAAAGELARYAAGLPFAHPVRPESLGHSA
>CP029618.1|AZM46056.1|2301044_2302628_-|dihydrofolate-synthase
MSAREEPAGPDPDETPGSPDTPGGPEDDAFEEIVGTETDRDPDLAVIEAGSRTLRAQGGPPAGDGVPAVPADPEVARALREAEAELLARWPETRIDPSLERIQALLDILGEPQRAYPSIHLTGTNGKSSTARMIEALLVACDLRTGRFTSPHLQSITERIGLDGTPIDAERFVETYRELKPYAELVDARQEHPLSFFEMLTAMAFAAFAEAPVDVAVVEVGLGGTWDSTNVIDASVAVVTPIAVDHSRLLGDTPGAIAADKAGIVKKTATPPGGGTGTVVIMAQQPVDAAQVILKRAVEMDATVAREGMEFGVLSREVAVGGQLLTLRGLGGEYPEVFLPLHGEHMAHNAAVALAAVEAFFGVGSEHARSLDADTVRRAFAAVTSPGRLEVVRTSPTVILDAAHNPAGALATAAGVQEAFGFSRLVGVVGTSREKDVRGVLEAFEPIFSEVVITRNSTTRAMDPDELAAIAVEVFGSERVQVEPRLDDALEAAITLAEEEDEYAGAGVLVTGSVITAGEARLLLGAK
>CP029618.1|AZM46055.1|2300572_2300953_-|DUF4233-domain-containing-protein
MRTLCASTLIGEILVVGLTGLVAMQQSDLSNGTIWGVSGAAMVLCVLLCGMLGRPGAVQVGWGLQIALIASGFVVPSMFFLGAVFAALWWASVHYGRIVDEAKAARARAAAEQTGGAPAEPGGAPA
>CP029618.1|AZM46054.1|2300057_2300471_-|nucleoside-diphosphate-kinase
MSQRTLVLLKPDAVRRGLVGEIIGRIERKADWSIAALELRTLDRSILEQHYAEHVGRPFYEPLVEFMASGPVVALVVEGERVIEGVRALSGPTDPIAAAPGSIRGDFGTVVRENLVHASDSEESAARELKLFFPDLA
>CP029618.1|AZM46053.1|2298787_2299807_-|rod-shape-determining-protein
MSFIGRDMAVDLGTANTLVYVRGRGIVLNEPSVVAINTNTGGILAVGAEAKKMIGRTPGNIVAVRPLKDGVIADFEITERMLRYFILKIHKRRYLARPRVVVCVPSGITGVERRAVIEASTQAGARQVHIIEEPMAAAIGSGLPVHEATGNMVVDIGGGTTEVAVISLGGIVTAQSIRVAGDELDNAIIQHIKKEYSLLLGERTAENIKITIGSAYDTDRDEHTEIRGRDLVSGLPKTVVISSAEVRKAMEEPLNAIVDAVKTTLDKCPPELSGDIMDRGIVLTGGGALLAGLDERLRHETGMPIHLAEEPLDSVALGSGKCVEEFEALQQVLDAQPRR
>CP029618.1|AZM46061.1|2311652_2313062_-|trigger-factor
MKSAVETLNPTRVRLTVEVPFEELKPSLDAAYKKINQQVTVPGFRKGKIPARIIDQRFGRGAVLEEAVNDALPKLYEDAVNEGDLKPLGRPEVDITELKDNETLTFTAEVDIRPEFEIPDYSGISVEVDAIEVPDEDVDKSVEQLRERFASTTPVERPAAEGDVVTIDLEASVDGKVLDDGVASGVTYTIGSGELLDGIDEAVTGLEAGGSATFASELKGGSAAGQEAQVKVEVTQVAERELPELDDEFAQMASEFDTLEEMRADSRKRLEQMKRYDQAQQAQEKVLDELLGLVEIPVPEKLLEEEISTRRHNLENHQLAQMGMNLEGYLKLQEKTAEEFETELKEQAERGIRTQFVLDELVGKEQVNVGQEELTEHLMRRAQSSGMSPDQFAQAVVEGGQVPVLVGEVARGKALAVVVEAATIKDTNGEPVDLSDEDETAETVEAASEETAEATDAEATEEKPEKAEA
>CP029618.1|AZM46062.1|2313734_2313929_-|hypothetical-protein
MAISLSLVLLMGIILVVLIRGGSIKVGPAIVAVLFGFFLASTSAAPDIQDALDEISQSISDIGT
>CP029618.1|AZM46063.1|2314551_2315691_+|hypothetical-protein
MTHLPQTAARPAGDSGKPKTRDPFFDNAKYLAIVLVALGHAWEPLRDDSRAASALYMLVYSFHMPAFILISGYMSRSFDLGRPGRVQRLVTGVLVPYVIFETAYTFFNRWAGDVPGYRISILDPWYLTWFLIALFVWRMTTPLWKAVRWPVPLALVIATAASMSDTVGNDLDLQRVLQFMPFFVLGLMLRPEHFDLVRRREVRLLSVPVGLMAAVVAYWAVPRMNAGWFYHRDSAQELGAPIWAGPVMTFAMFGCALVLTVCFLAWVPRRTMWFTVLGAGTLYGYLLHGFLAKGSRFWGWYDNDFAHTPLGAIAVTAIAAVIVTVLCTPPVRRMFRWTMEPKMNWLFRSDDGGGRGGSPAAEPAKAEQTPERERATASR
>CP029618.1|AZM46064.1|2315806_2318353_-|ABC-transporter-permease
MSGGLAGAGVRARTNGLARAALRFRPAGFAGTFVALMMAALIVSACGILLETGVRASVPPERYAHAPVVVAADQRAHMTVGSGDGAYDASEQVPDRARVGAGLAERVASARGVAAAVPDVTFPARLAAGEGAPDGAALTAQGWGSHAFTGTSLAAGSAPGTDEVVLDRATARAAGAAVGDTIALVLPSGQQEFRVSGIAAAASARTSGAAYLADDAAARAAGHPGRFDAVAVLAADGVGAGQLADAVRGVVGDRAEVHTGDGRGGVEDTGVAAAEELLTGLGGSFGGIAATVAVFTAAGTVALSVAQRKREFALLRAIGATPRQIRRSVAAEALLVAPVAGLAGLLPGIGLASWWFGQLKDRGAVPAAVDLHVSPVPLAVAVGTALLSALVAGWAAARRPARTKPGQALTEASVERLRPGIVRTVLGLGAVTGGILLSGVAARSAGDDAAEAALGVVMLFMLAVALLGPLIARLAAGLFGLPLRAGDASAELAAANSRTNARRLASAITPIVLATAFASVLVFMHTSEDHATAAQQRAGVTADHVVTHPGGLPADAAERAARQPGVDAAVGVLRSEVLVPVGGGGDRWLQGATAQGVSGDGLTRVQDLDVRQGSLDRLPEPGTVALDENLARSAGTGVGERVELRLPDGTSEKAEVVATYGRGLGLAQVTLDRGALAGHVTAGYDTDLLVSGGSAAGLGALGGAGTAVTDAAGYAQQQDVDRSLNRWANFTMAGVLGGFAAVAALNTLVMTVLDRRRELGMLRLIGSTRRQVLGMIRWEGLLVGVAGLVLGGAIAAATLVPMVRGITGGDPYLPPLTVAAFTAGAVGLGLLGTVLPARAALRRAEPAG
>CP029618.1|AZM46065.1|2318349_2319159_-|ABC-transporter-ATP-binding-protein
MRLRTRGERQDHGAPAAPGHAVELRGVQRRYGRGAGAVHALRGIDLALPRGTYTAVMGPSGSGKSTLLQCAAGLDRPTAGSVLLGGTELTRLGENKLTELRRSRLGFVFQAFNLLPSLTVSQNVLLPMRLAGFRADHARAAEVLAQVGLAAHGRRRPAELSGGQQQRVAIARALVTRPDVIFADEPTGALDTRTAGEILALLRHAVDSLGATVVMVTHDPVAASYADVALFLADGALAGSLQRPTAEQVAARMTALDPRDAARGAERAA
>CP029618.1|AZM46066.1|2319459_2320653_+|cation/H(+)-antiporter
MGGAFMAAAILARIGSRIGLPTIPLFILAGILLGPNTPGIVLVKDPHDLEMLTALGLVLLLFYLGLEFHMDDLKSGGRRMAVAGGIYLLLNVGAGAGFGFALGWGTSEALVLAGVLGISSSAIVTKILVDLGRIGNGETKPILGIIVIEDIFLAIYLAVLQPVLSGAEGPGEAALQAGKAMAFLLVLATIARFGTKVIGRLFDTRDNELLVISFLGAAVLVAGISEWFGVADAIGAFMVGLMLGSTTSAERIRTLVHPLRDAFGAIFFFGFGLSIDPGDLPSVAAPVALAVLLTIVMNISAGLAAAKLYGFGAAPASNIALTLLARGEFALILATMAATAGLDRRLSPFIAGYVLVLAVLAPLAAGRSHWLARFLPGGKPPAGGAALEPEPETAGAK
>CP029618.1|AZM46067.1|2320719_2321862_-|hypothetical-protein
MAGGAGSTSQAARWHKALHRARVGVRRAGVDYFRGEGSDWMALVVLLLTIPALAAGTILSAAWISPAALVLPIFIGGLVLRPASLLALYAASATALIVEAMLLGPYAEGPARVTPGTVLVIASVGLTGLTVAQFRSRVGVPWRRGGTMLFDLRERIRVQSKLPRLPRGWHAEMSLRPAGGQSFSGDFVVASRTHGGQILEAVLTDVSGKGMAAGSRALLLSGAFGGLLGSLPPHDFLPAANGYLLRQEWQEGFATSVHLVLDLESGDYELFSAGHVPGVQLSAGTGRWEEKGAEGPLLGVVEEAQFDPLKGTLRRGDVLMLFSDGLVEAPDRDLTEGMDRLIGEADHYASSTFRGAAWHLIEKVAKDVKDDRALLLICRE
>CP029618.1|AZM46068.1|2322007_2322817_-|DNA-glycosylase
MPEGHTIHRLSVEYGVRFGGRAVRAASPQGKFADGAALIDGCRLTGTDAHGKHLFLGFGPVGHLHVHLGIYGKVGFGDGPAPPPVGAVRLRLATGAGYADLRGPSACELVTEEEKDAVHARLGDDPLRAGDDGEAAWARISRSRAPVATLLMDQRVISGVGNIYRTEVLFRHGIDPYRAGRDLGRAAWEAVWADLAALMREGVRTGRIDTVRPEHLPEAMGRPPRVDEHGGEVYVYRRAGRPCHLCGTDVRTATLAARNLFWCPGCQPT
>CP029618.1|AZM46069.1|2322868_2323354_-|ribose-5-phosphate-isomerase
MRVYLGSDHAGYELKEHLLVWLREHGHEPVDCGPLIYDAADDYPPFCLRAAERTAADPGSLGVVIGGSGNGEQIAANKVAGVRSALAWSEETARLAREHNDANVVSVGARMHTRDEATSFVEVFLATPYAGEERHQRRIDMLSAYEQSGKLPDVPAHHPQP
>CP029618.1|AZM46070.1|2323378_2323996_-|biotin-transporter-BioY
MSTAAVSSPHRARPGAVLADVLPASTAARARLRDIALVAGGAALTGAAAQLSVPVPGSPVPVTGQTFAALLVGASLGTGRAFLSLLLYAVAGMAGMPWFAEGSSGWGMPSFGYVLGMLLAAAAVGALARRGGDRDVWRTAGTMVLGSLVIYAVGVPYLALSLDVSLGEAVSLGLTPYLLGDALKAALAMGALPAAWHIAGRAHRG

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Crispr_ID: CP029618_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP029618_2

3214048-3214152

Orphan

Consensus_repeat	Method
CCTTGGGCGGGCGTGAGGGCACGA	CRISPRCasFinder

1 spacers

WYL

The CRISPR arrays of CP029618_2

>merge|CP029618|2|3214048-3214152|CRISPRCasFinder
CCTTGGGCGGGCGTGAGGGCACGAGCGGGCCGAGCACGAGCAGGCCGACCGACCCAGCGGACCGACCACGAGCACCCAGCCGCCTGGGCGGGCGTGAGGGCACGA

>CP029618|2|2|3214048-3214152|CRISPRCasFinder
CCTTGGGCGGGCGTGAGGGCACGA	GCGGGCCGAGCACGAGCAGGCCGACCGACCCAGCGGACCGACCACGAGCACCCAGCC
GCCTGGGCGGGCGTGAGGGCACGA

Protein	Signature genes	Signature genes Name	Protein_function
CP029618.1\|AZM46713.1\|3214229_3215540_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340913
CP029618.1\|AZM46711.1\|3210802_3211396_-\|hypothetical-protein	unknown	unknown	unknown
CP029618.1\|AZM50758.1\|3212779_3212989_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377231
CP029618.1\|AZM46721.1\|3221874_3222450_+\|RNA-polymerase-subunit-sigma-70	unknown	unknown	gnl\|CDD\|237125
CP029618.1\|AZM50757.1\|3205734_3206745_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379501
CP029618.1\|AZM46709.1\|3209247_3210150_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP029618.1\|AZM46714.1\|3215969_3216938_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238861
CP029618.1\|AZM46715.1\|3217036_3218098_+\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|181818
CP029618.1\|AZM46706.1\|3206822_3207797_-\|DNA-binding-transcriptional-regulator	WYL	COG2378_WYL_CAS-I:CAS-III	gnl\|CDD\|225253
CP029618.1\|AZM46716.1\|3218210_3219044_-\|NADPH:quinone-reductase	unknown	unknown	gnl\|CDD\|376808
CP029618.1\|AZM50759.1\|3212890_3213313_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340413
CP029618.1\|AZM46712.1\|3211536_3212817_+\|glycosyl-transferase	unknown	unknown	gnl\|CDD\|340847
CP029618.1\|AZM46722.1\|3222446_3223628_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|274422
CP029618.1\|AZM46708.1\|3208318_3208867_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368855
CP029618.1\|AZM46720.1\|3221148_3221556_-\|anti-sigma-factor-antagonist	unknown	unknown	gnl\|CDD\|132914
CP029618.1\|AZM46718.1\|3220249_3220561_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224393
CP029618.1\|AZM46717.1\|3219342_3219843_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|340413
CP029618.1\|AZM46707.1\|3207859_3208255_+\|enamine-deaminase-RidA	unknown	unknown	gnl\|CDD\|100004
CP029618.1\|AZM46710.1\|3210219_3210729_-\|Mini-circle-protein	unknown	unknown	gnl\|CDD\|368218
CP029618.1\|AZM46719.1\|3220557_3221130_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP029618.1\|AZM46713.1\|3214229_3215540_-\|MFS-transporter	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.99433e-97
CP029618.1\|AZM50758.1\|3212779_3212989_-\|hypothetical-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	3.55639e-05
CP029618.1\|AZM46721.1\|3221874_3222450_+\|RNA-polymerase-subunit-sigma-70	gnl\|CDD\|237125	PRK12519, PRK12519, RNA polymerase sigma factor; Provisional.	4.29555e-23
CP029618.1\|AZM50757.1\|3205734_3206745_+\|hypothetical-protein	gnl\|CDD\|379501	pfam14200, RicinB_lectin_2, Ricin-type beta-trefoil lectin domain-like.	0.000301409
CP029618.1\|AZM46709.1\|3209247_3210150_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	4.23997e-05
CP029618.1\|AZM46714.1\|3215969_3216938_+\|hypothetical-protein	gnl\|CDD\|238861	cd01823, SEST_like, SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases, but may lack the carboxylic acid.	2.07967e-59
CP029618.1\|AZM46715.1\|3217036_3218098_+\|AraC-family-transcriptional-regulator	gnl\|CDD\|181818	PRK09393, ftrA, transcriptional activator FtrA; Provisional.	1.59589e-113
CP029618.1\|AZM46706.1\|3206822_3207797_-\|DNA-binding-transcriptional-regulator	gnl\|CDD\|225253	COG2378, COG2378, Predicted transcriptional regulator [Transcription].	8.95851e-33
CP029618.1\|AZM46716.1\|3218210_3219044_-\|NADPH:quinone-reductase	gnl\|CDD\|376808	pfam02525, Flavodoxin_2, Flavodoxin-like fold. This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.	5.04561e-54
CP029618.1\|AZM50759.1\|3212890_3213313_+\|hypothetical-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	2.18865e-14
CP029618.1\|AZM46712.1\|3211536_3212817_+\|glycosyl-transferase	gnl\|CDD\|340847	cd03820, GT4_AmsD-like, amylovoran biosynthesis glycosyltransferase AmsD and similar proteins. This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.	1.07514e-100
CP029618.1\|AZM46722.1\|3222446_3223628_+\|hypothetical-protein	gnl\|CDD\|274422	TIGR03083, TIGR03083, uncharacterized Actinobacterial protein TIGR03083. This protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.	0.000666534
CP029618.1\|AZM46708.1\|3208318_3208867_-\|hypothetical-protein	gnl\|CDD\|368855	pfam06353, DUF1062, Protein of unknown function (DUF1062). This family consists of several hypothetical bacterial proteins of unknown function.	3.95623e-51
CP029618.1\|AZM46720.1\|3221148_3221556_-\|anti-sigma-factor-antagonist	gnl\|CDD\|132914	cd07043, STAS_anti-anti-sigma_factors, Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation. Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.	2.186e-22
CP029618.1\|AZM46718.1\|3220249_3220561_+\|transcriptional-regulator	gnl\|CDD\|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	1.80774e-18
CP029618.1\|AZM46717.1\|3219342_3219843_-\|hypothetical-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	7.06572e-15
CP029618.1\|AZM46707.1\|3207859_3208255_+\|enamine-deaminase-RidA	gnl\|CDD\|100004	cd00448, YjgF_YER057c_UK114_family, YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.	2.17144e-21
CP029618.1\|AZM46710.1\|3210219_3210729_-\|Mini-circle-protein	gnl\|CDD\|368218	pfam04978, DUF664, Protein of unknown function (DUF664). This family is commonly found in Streptomyces coelicolor and is of unknown function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	2.65366e-41

>CP029618.1|AZM50759.1|3212890_3213313_+|hypothetical-protein
MASPLAIRVRYSTLRRSCVPGQGVRLSGTVGIHESPNDFPRNGEVSLTVETVVAELCANAVLHGRVPGRDFHLAMRLRVDGVLRIEVADARRERVPVLERRYDVEGERGRGLLLVEAMADRWGVAERQAVGKIVRCELDT
>CP029618.1|AZM50758.1|3212779_3212989_-|hypothetical-protein
MDPHGAAEANTLARHTAPTESAVPDTYREWGGDPVWRNPSVHPDGPVLTFPADAWQAFTDFARGLGAGR
>CP029618.1|AZM46712.1|3211536_3212817_+|glycosyl-transferase
MRISFLLHNTYGIGGTIRTTFTLAQALAERHDVELVSVFRHRDEPMMEAPLGIPIRTLVDLRRRSPDYAGDLPDHRKPARVFPRGDGRHNQYSKLTDDRIGAYLRTVDADVVVGTRPGLNVHIARQTRRGPVRVAQEHLTLDGHGGRLRRELGIRYGLLDAVTTVTEADAHAYRTRLNLPGVRIEAVPNSVPAPAVAPADGTAKVVVAAGRLTRVKRYDLLIEAFAKVAAARPDWTLRIYGSGDRTGNERDALRAQIADLRLTEHVFLMGNASPMEREWVKGSIAAVTSSKESFGMTIVEAMRCALPVVSTDCPHGPGEIIEDGVDGRLVPVGDANAVADALLELIQDDALRRRTGAAARAASERFDPTRIAARHEAIFTELTERPRPRGLLRDLALRSRGTAYGSAYTARHVAATALRRARGRSR
>CP029618.1|AZM46711.1|3210802_3211396_-|hypothetical-protein
MLENIARNKRYVVGSVLVLAGVVGVVWSVWRPWYNGRDGRFYALGSVFDGISDTRAQLFGSIFLPFAFAALVAIYGTLTRSRRLVILAALLVLFITALWMLRQSQLVGGLKVSTDGTGLDVGTANAVIGAALMLVGVGVWGKQQRRPLTPPAEEPEPGPRLRSVSTTGKPGRSGRPGEAEAPEERPEERPEEPPRAA
>CP029618.1|AZM46710.1|3210219_3210729_-|Mini-circle-protein
MTVDNRVGPPRLGSERDTLRACLDYHRATLARKCEGLSDEELRRRSMPPSTLSLLGLVRHMAEVERAWFRRVFEDHDAPMVWSDRIDFQAAYDASGSTRAEAFGAWEAEVGRSRRIEREAESLDLVGYQPRWDEDVSLRMVMVHVLLEYGRHNGHADFLREGIDGTVGA
>CP029618.1|AZM46709.1|3209247_3210150_+|GNAT-family-N-acetyltransferase
MTDPVIIRALTESDAPLFDTLPDPLGAREGHRNTRFRTEWKHVALRDGRVVARGAWWGGPDDAEPLSVNWFDVAEGEEEAGTRLLLSVPWRVELEINLPGGWREDPALRAAADTRFAAARAAGYELLVERFLYRWTPEGGLPERPGRLRFRAEPDDGVFFDALRRIHSATLDAHALKAIGEGGLDQAAQEEIDFFHWCPSPREWWQTAYTPEGELAGIHIPAHNPSGPIVGFIGVLPEHRGHGYSYDLLAECTHFLVERGAEFVSAATDRGNFPMAANFAKAGYPVVRERVNFHPADLKE
>CP029618.1|AZM46708.1|3208318_3208867_-|hypothetical-protein
MLTDWLVMPTCLPLVRRRCYACASGRFRANGKFRVNAHHKLLDVWLLALCTGCGVTAKLTVLERVNVRSVRPELLARLHHDDIHLAATLLQDPAFQRRNRVALDWTGAWRLDTGGTDHLHREVIDVTVRFAARIPVRPVRLIADGCALTRAEAERLIDEGRLISAVRLNARLTGDFTFTLKR
>CP029618.1|AZM46707.1|3207859_3208255_+|enamine-deaminase-RidA
MERTAINPVTWSTDMGFNQGELASGHTRTLFVSGQTAMSPEGRPQHPDDMAAQLALSLDNLEAVLAGADMSLENLVRLNVYTTDVDALFPHYGELAARLAAAKAAPATTMLGVTRLAIPTLLVELEATAVA
>CP029618.1|AZM46706.1|3206822_3207797_-|DNA-binding-transcriptional-regulator
MRADRLVSLVLLLRQRGRLSAATLARELEVSTRTVLRDIEALSAAGVPVHSERGRHGGFALLPGFRTELTGLNHDEALALLIAGSRRGAQAFGLGSALASAMLKVVDALPPGYRDTAAGVAERLLVDPETDLLARPLTADEVPDDVIAAIRGAVFAGRKLRIRYAPEGRAAAWRTVDPIGLVTVRDKGYLLAARDGADRTYRLSRVRAAEELPEPAQRPERVDLDRAWQERSARFRSGGDQVAVTVRITPRRREELVGTALAVLAEDVEADGRLRLEVAFQDARHAEWAVWQLATDAEALTPEWLRTALRDRAAALAAHYASPS
>CP029618.1|AZM50757.1|3205734_3206745_+|hypothetical-protein
MHEEDGSPGPRPEPPEPARAPRPEQLRTRAEYLAALRELRTWSGLTYRELEAKAGTHADSLPASTIATTLGRTTLPRERFVDAFTRACGLAEQDVGPWLEARRRIATREHAPPPPGKDDDREPAPPPPGPAPRWRWAAGLLAAVGIGAGGTLGVQALLPDGSGPGEQRAAVGNLAVPGLDLQAVGSWAEIRPARSPELCVTEGTDRTGRYGSAVAAQQPCARSALPRVYLEPVGDGAVQIQWHHPEHGVGCLTAMREGPGRGLLEPRDACADDDPAQRFRLEAAGEGAERRFRIRPDTGECLAPRDEDTGPGAEIARARCSGGAEEEFTISLTPPP
>CP029618.1|AZM46713.1|3214229_3215540_-|MFS-transporter
MAGARADTGAAAPVKPPAKWRVHRAWFVAAVTFVTVVAAASFVALPGLLIGPLHDEFGWSRGTIGLAASVNLTLYGVTAPFAAALMDRFGIRRVVAFALLMIATGALLSHWMTASWQLILYWGLLIGLGTGSMALAFSATVTNRWFVKHKGLVTGLLTAATASGQLVFLPLLSWVVETHGWRPATVTVALVSAAAVPFVWLLLRDHPADVGLAPYGSDEFVPKPPPQRGAAGRALRVLRDASRSGTFWLLCGAFAICGASTNGIIRTHFVPSAHDHGMAMTAAASLLALVGIFDIIGTIASGWLTDRYDARRLLAVYYGLRGLSLMFLPLLLGPSIHPPMIFFIVFYGLDWVATVPPTLALCREHFGEDSAIVFGWVLASHQIGAALVAWLGGVARDVTGSYDMVWLASGGLCALAAMMSLVVRQGRKDEPAGATA
>CP029618.1|AZM46714.1|3215969_3216938_+|hypothetical-protein
MARLRTRLALLGSAAALAAGAVVPGQFAGAHPAAAAEDQQWVALGDSYTAGVIRAAGDAFEYPRDGCERTGRSYPQVIDRDLGGLFDLTNVSCGAATIENVTDTPQEPIGRHLPPFSEDPDYPFPAVPPQSEAVGPDTDVITVGVGGNTLGFAEILTTCMRVGGENDGAGTPCKDALGAGIQARLDKVSQEYDRMLAVLHERAPGAKILAVGYPTIVPQSTAKCGYGDLTKFGTITQGDLNWLRQDVLDPLNRTIEKSTGTQESASFVDLSASSQNHSVCDDTKWVEGFVTLPDQLSFVHPNALGHRNAADHVEEAMLNTLD
>CP029618.1|AZM46715.1|3217036_3218098_+|AraC-family-transcriptional-regulator
MGSVQRPAVVQEAVVQEAVPVPVFRHPQRHPVAVFVRHGMLPIELGIVHRLFGRARSAAGDPLYEVVTCTVAPGEVRTDADVTINVRYGPEALAQARTVIVPASHEADEAYTRGRLPAELAGALAYVRPETRLASICTGAFVLASAGLLDGRPATTHWASGDRFRALFPKVRFDPDVLYVDDGDVLTSAGVASGVDLCLHMIRHDHGSAVANDVARRTVVPPHRDGGQAQFVRRPVPEPAVSTTAKARAWALARLHEPLALRDLAACESMSVRTFTRRFRDEVGMSPGQWLTVQRVERARQLLEDTDLPVDRIATDAGFGTAASLRQHMQAALGVSPSAYRRTFRAESEGAVA
>CP029618.1|AZM46716.1|3218210_3219044_-|NADPH:quinone-reductase
MNVLWLFAHPEHRSLNAALRDDGIRALRAAGHEVRQSDLYAMGFKAVLDAGDYAGGDADRLLVGDAQEDAWRAGRVSPDIAAEHEKLAWADALVVHFPLWWFGPPAILKGWFDRVLVQGLASKVKDAAGRTRRYGDGGLAGRRALVVTSVGAREASFGPRGIHGHVDEVLWPLHHGTFFYTGMAPLPPFVVYGADRLTREEYPRVAAGLAERLRDLWTTAPLPYRPERSGDYDEELTLRPELAAGETGLTIHRDQRPGTPPTSPHNPAHPPQGRRPL
>CP029618.1|AZM46717.1|3219342_3219843_-|hypothetical-protein
MQTLQVQLKVWPDPVEVGRARRWTRARLAWTGVTADEPYAESLVMLVSELVTNAVVHTDRPAELRLALPASAADCGPYRVEVVDTCAAPPRQRRAHEYETHGRGLELVDAIADRWGWQAEGFGKVIWCEIDRACAFAPPPGERADGADGALFAGAHEHARAGTNST
>CP029618.1|AZM46718.1|3220249_3220561_+|transcriptional-regulator
MYNFLYMSERVHNRLAVIRAERSVSRKQLAEAVGAHYQTIGHIERGQYNPSLDLALRIAEYFELPVEVLFALRPFRPLSDELYGPGKADGNDSEHDSADRGAR
>CP029618.1|AZM46719.1|3220557_3221130_+|hypothetical-protein
MTQPTTERPRGGARQATTYDRAMFRIMNDPAARPVFATAGRRRAAVGAHVALTGATLACLTLLYRLDDAWLIAPLAALLPLWVIATGVLNGGTRGLLELRTRMLDERQLADRDRAGAVAHRAATVLLAVAAGMFVLAEAVGADGLPAVPAVWVLVYAVVVVWLMPLWVAGLQARDEPADEPADEAPEEAG
>CP029618.1|AZM46720.1|3221148_3221556_-|anti-sigma-factor-antagonist
MLQVTTDNRGDWYVLWVCGELDLVTSPRVRQHVHDAVAEGRRRLVLDLSAVRFCDSSGVGVLIAARRLLSSCGGDFRLILPADGGVGASGGVSGTAVSGGAHVNRVLAALGVRRLFAVYADVDDATSGTAEPLSA
>CP029618.1|AZM46721.1|3221874_3222450_+|RNA-polymerase-subunit-sigma-70
MAHGTGPHGTGQGAVPPRWNRKMQQRLARGEAAALSELYDRFAPLVYGLAQRVLENEEEANGVLAEVFSYVWQHPDAYDPKRGQLRSFLAGLAHKHAVRRLRWAVIQAGAAGEIEDSEERIRAVSAAARADYIVTSMPEPQRAALELAYFKRRDYRQTAEELGVSPDEARRRLRLGLQMLATAHTEAGRPS
>CP029618.1|AZM46722.1|3222446_3223628_+|hypothetical-protein
MIMGPYDHGRLKSLLGAWALAACAPEETAAVEAHLTDCAPCADEALRLRDAVRLLHPHDNLDMDPALRSRVLELCLTRRMPGIPMPGWSVPYDAEAARLDALLADMNEADWGAPVQLAWYDDDRPAVRETSVAGVIGHLLAVDGLLALALGLPDPLAADAPAAGTHPRTVASPAERTEALWRVAGSSYAEQQSLAREFRRKHASKMRSEWRDQTYTLIRTAGFAGSGVADVQVPYGGGAALPLRDAFLDRAFECWMHAWDIAEAVDYPYVPPTPEHMHLMIDLAARLLPQTLADRRRSGRAAPPRTLVAAGTPGRTLHLEIEGKGGGNWYLPLDSPAAVAGPERAVAHVALEGLEFCRLAAGHVSPAEAAVGSDGEREAVEDFLYATASLSRL

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Crispr_ID: CP029618_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP029618_3

3691062-3691142

Orphan

Consensus_repeat	Method
GCGGGCTGCCGGGCGCCAGGGTCT	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of CP029618_3

>merge|CP029618|3|3691062-3691142|CRISPRCasFinder
GCGGGCTGCCGGGCGCCAGGGTCTCCCCGATCGCCGATCCCCTCGGCGGACGGGGGGGCGGGCTGCCGGGCGCCGGGTCTT

>CP029618|3|3|3691062-3691142|CRISPRCasFinder
GCGGGCTGCCGGGCGCCAGGGTCT	CCCCGATCGCCGATCCCCTCGGCGGACGGGGGG
GCGGGCTGCCGGGCGCCGGGTCTT

Protein	Signature genes	Signature genes Name	Protein_function
CP029618.1\|AZM47088.1\|3694421_3694856_+\|ATP-binding-protein	unknown	unknown	gnl\|CDD\|340413
CP029618.1\|AZM47092.1\|3698630_3699908_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
CP029618.1\|AZM47091.1\|3696977_3697430_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370266
CP029618.1\|AZM47090.1\|3695507_3696101_+\|shikimate-kinase	unknown	unknown	gnl\|CDD\|379082
CP029618.1\|AZM47080.1\|3684005_3684632_-\|DUF305-domain-containing-protein	unknown	unknown	gnl\|CDD\|367619
CP029618.1\|AZM47083.1\|3688087_3688921_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236126
CP029618.1\|AZM47087.1\|3693329_3694181_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|379262
CP029618.1\|AZM47086.1\|3693126_3693318_-\|hypothetical-protein	unknown	unknown	unknown
CP029618.1\|AZM47082.1\|3685941_3688017_+\|heavy-metal-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319849
CP029618.1\|AZM47077.1\|3681587_3682178_-\|RNA-polymerase-subunit-sigma	unknown	unknown	gnl\|CDD\|224511
CP029618.1\|AZM47079.1\|3683384_3683969_+\|hypothetical-protein	unknown	unknown	unknown
CP029618.1\|AZM47078.1\|3682316_3683360_+\|hypothetical-protein	unknown	unknown	unknown
CP029618.1\|AZM50799.1\|3684766_3685333_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236090
CP029618.1\|AZM47084.1\|3688991_3690242_-\|MFS-transporter	unknown	unknown	gnl\|CDD\|340863
CP029618.1\|AZM47085.1\|3692011_3692389_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378915
CP029618.1\|AZM47076.1\|3680955_3681576_-\|hypothetical-protein	unknown	unknown	unknown
CP029618.1\|AZM47081.1\|3685427_3685841_-\|transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|197713
CP029618.1\|AZM50800.1\|3697696_3698650_+\|hypothetical-protein	unknown	unknown	unknown
CP029618.1\|AZM47089.1\|3694890_3695358_-\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240040
CP029618.1\|AZM47093.1\|3701821_3702664_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|224331

Protein	Function_ID	Function_description	E-value
CP029618.1\|AZM47088.1\|3694421_3694856_+\|ATP-binding-protein	gnl\|CDD\|340413	cd16936, HATPase_RsbW-like, Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains. This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.	4.78966e-15
CP029618.1\|AZM47091.1\|3696977_3697430_-\|hypothetical-protein	gnl\|CDD\|370266	pfam09056, Phospholip_A2_3, Prokaryotic phospholipase A2. The prokaryotic phospholipase A2 domain is predominantly found in bacterial and fungal phospholipases, as well as various hypothetical and putative proteins. It enables the liberation of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides. The domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments.	7.26595e-47
CP029618.1\|AZM47090.1\|3695507_3696101_+\|shikimate-kinase	gnl\|CDD\|379082	pfam13238, AAA_18, AAA domain.	9.06774e-05
CP029618.1\|AZM47080.1\|3684005_3684632_-\|DUF305-domain-containing-protein	gnl\|CDD\|367619	pfam03713, DUF305, Domain of unknown function (DUF305). Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1. This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important. This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	2.96498e-49
CP029618.1\|AZM47083.1\|3688087_3688921_-\|hypothetical-protein	gnl\|CDD\|236126	PRK07899, rpsA, 30S ribosomal protein S1; Reviewed.	1.62403e-46
CP029618.1\|AZM47087.1\|3693329_3694181_-\|transcriptional-regulator	gnl\|CDD\|379262	pfam13560, HTH_31, Helix-turn-helix domain. This domain is a helix-turn-helix domain that probably binds to DNA.	2.43884e-06
CP029618.1\|AZM47092.1\|3698630_3699908_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.58919e-61
CP029618.1\|AZM47082.1\|3685941_3688017_+\|heavy-metal-translocating-P-type-ATPase	gnl\|CDD\|319849	cd07551, P-type_ATPase_HM_ZosA_PfeT-like, P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron. Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
CP029618.1\|AZM47077.1\|3681587_3682178_-\|RNA-polymerase-subunit-sigma	gnl\|CDD\|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	5.7843e-26
CP029618.1\|AZM50799.1\|3684766_3685333_-\|hypothetical-protein	gnl\|CDD\|236090	PRK07764, PRK07764, DNA polymerase III subunits gamma and tau; Validated.	2.80994e-05
CP029618.1\|AZM47084.1\|3688991_3690242_-\|MFS-transporter	gnl\|CDD\|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.90807e-49
CP029618.1\|AZM47085.1\|3692011_3692389_-\|hypothetical-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.00216114
CP029618.1\|AZM47081.1\|3685427_3685841_-\|transcriptional-regulator	gnl\|CDD\|197713	smart00418, HTH_ARSR, helix_turn_helix, Arsenical Resistance Operon Repressor.	6.69726e-18
CP029618.1\|AZM47089.1\|3694890_3695358_-\|NUDIX-hydrolase	gnl\|CDD\|240040	cd04684, Nudix_Hydrolase_25, Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.13268e-31
CP029618.1\|AZM47093.1\|3701821_3702664_-\|hypothetical-protein	gnl\|CDD\|224331	COG1413, COG1413, FOG: HEAT repeat [Energy production and conversion].	0.00390695

>CP029618.1|AZM47084.1|3688991_3690242_-|MFS-transporter
MARKLRAGGAGDPPSPTPLWTTDFRLFFTARTTSLLGDAMLPVAITAAVLGAGYGASGVGYALAALVAPFAALIIFGGVLSDRFGARRLMVLSDAARLVFQMALALLFLVGTPPLWQILVLLAFVGAGSALFQPGVASITPRVARDVQKANATLRIAESVTLVLGPSLAGLLLAVSSPAVVVALDAVTYAVSGACLFALRAVPRGPGKAAREGAPSFRADLVEGWREFSARTWLWSVIVVFMLWQLAGAGPTTTLGNSTLVTDYGASTFGLVMSSLGAGSVLGGLVAIRLRPRHPLRAGALSMTLWALMPLGVALGLSAPLVALCYGVSGIGAAFWIVMFHTSVQTHVPQDVLGRVHAYDAAGSLVMKPVGQAAAGPLAGVVGTVPLLFVSATMAVLTCLLLLAIPAVRGLRRVER
>CP029618.1|AZM47083.1|3688087_3688921_-|hypothetical-protein
MGAAPDDQTSREFLAGIRVGDICSGSVAEVTRSRGVAVTLDGFPTCPLGTVWPADVSWRRNTAVAVKAGQRITAEVMAVDLDEGQVRLAMTATENPELWAFLKSRHRGEILSGTVAAIERFGVFVSLDDGPDHPVFPGVGFITIPELSWRHIDAASDVVRVGQHVSCEFLQFDDWNGEARLSLKATQPDPFAAFAEGTAVGETLHGKVTKVVPFGVFVQVADGIEGLVRPREPTRTPVETPEDVLQAGDEVTVVVTEIDRQRRRLALSRREVPPDIQ
>CP029618.1|AZM47082.1|3685941_3688017_+|heavy-metal-translocating-P-type-ATPase
MPHTLTQPDPQTARTAGTPAPAAAPRRPGPFSVPEARWAAAALALFLLALPLDLLGAPAWTWGPLYALTYAAGGWEPGWSGLRALKDKTLDVDLLMVVAALGAAALGQFLDGGLLIVIFAASGALEAIATARTADSVRGLLDLAPATAVRVAADGTEEDVPTGQLRVGDVILVRPGSRIGADGRVLDGASEADQATITGEPLPVPKEPGDEVFAGTLNGTGALTVRVGRDPADSVIARIVAMVEEASRTKAPTQLFVEKIEQRYSIGMVAATVALFAVPLLLGAELESTLLRAMTFMIVASPCAVVLATMPPLLSAIANAGRHGVLVKSAVVMEQVGQADLAALDKTGTLTEGRPHLTDVRPLDGSGMTEDDLLALAAAAEHPAEHPLARAVVAAARERALPVPAVRDFTAAPGRGVAATVAGARVTVGSPAGLRGKDPCPGSGPGSGSGPDSGPVPGASPDSPPDAAAAARQAAGELEGEGRTAVVVTRDGTPVGVLGIADRTRPDAPGTVAALAALTGAPPLLLTGDNAPAAHRLAAGVGIAAADVHAGLLPQDKAETVRALQSGGRRVLLVGDGVNDAPALAAAHTGVAMGRAGSDLALETADAVVVRDELTAVPAVVALSRRARRLVVQNLVIAGVCIAGLVVWDLAWHLPLPLGVAGHEGSTVLVGLNGLRLLRTAAWRRAAAEGR
>CP029618.1|AZM47081.1|3685427_3685841_-|transcriptional-regulator
MGHGAATPGASDGGRVRLDAATAQKVAATLQALATPSRLLILARLREGPLPVSELAAEVGMEQSACSHQLRLLRNLGLVTGTRHGRSIVYALYDDHVAELLDQALHHTEHLRLGLTDTPAGTGRDDLRDEESAAARG
>CP029618.1|AZM50799.1|3684766_3685333_-|hypothetical-protein
MGPRRRPAGRLFVLLVLAVLAGVLGMHALGPGGAPAAERPTAMAPGHGGTEARAAMVAQTPLPVSGAPQASAGHVPAGQAPAAFVPAAQTPASPASHAPPAPHAPVAETPVATPAGDACSHTDGGSGHLSHADRTCAAAGTASAYAPPALADALPGAPAAAPAPIAGPAAGVPDRAPPDLAELQLLRI
>CP029618.1|AZM47080.1|3684005_3684632_-|DUF305-domain-containing-protein
MIRTRSLFRRGAAAATAGAVALLLAACGGNDDESGDHGKHGGASASGPAASQKEQNAADVTFAKGMIPHHRQAVEMADLAPERAASDEVKKLAAEIKKAQDPEIETLSGWLTSWGEDVPAEGEMDHSMHGSAGGMMSAEDMKSLEKAEGAAFDTAFMEMMIEHHEGAVAMAETEQADGAYPPAKKMAGQIISSQEAEIDAMKSMLDKG
>CP029618.1|AZM47079.1|3683384_3683969_+|hypothetical-protein
MIDPRWVFVSAVLGMAGSVRYAFAIVRGTVRPNLVTWSLWAAVPLIAFSAQLDSGVGLPAVQTLVAGAGPLVVVVTGVCTRQNLARLGAFDLACALAACAALGAWLGLGEAALAVVFAVAADAAAALPTVVKAWHDPASENLLFYVLVGTGATVTLLTITSWSPAAWAFAAYVLTLSVSLVAIVSGRRRALRYA
>CP029618.1|AZM47078.1|3682316_3683360_+|hypothetical-protein
MFGIIRPCRCRLPKGLAKEWLGHLCGLCLALRGQGGQVARAATNHDGLLISVLYDAQAAPAEGKAGGGWRTAGPCPLRRMRRAEVAHGDGAQLAAVVSLLLASAKIRDHVADGDGALARPVLAAPAQRVAGGWEAAGARGGAGLGFDTGVLVEAVERQREVEALAGPGTSVLVVTEPTELATAAAFAHTAKLAGRPGNEAALAEAGRLFGRVAHLLDAVQDAEDDRRTGAWNPITATGTPPARVRQLCDDATRGVALALADAEFTDDRLVRALLVGELERAVRRTFAHAGGGFGPPPPEFVPLGKGEESEEEEAKQEKHSNCDCGGCDGCGCDGDCCDCCGCCDCSC
>CP029618.1|AZM47077.1|3681587_3682178_-|RNA-polymerase-subunit-sigma
MVSNSGEAVRRIGTDPQAFEAFYRAHVEAVERFIARRIADPHRAADLTAEVFLATIESAEGYKPSRGAPVAWLYGIARNVLAGDRRRSARERDAGLRLAGRRLVEGDDIARLDDRIVAEAQARTLYEAMSRLPAHERAVLELVAVDGLSVSEAGKTLGIRAPTARVRLHRARRRVRDHFGAPVSPPAVSAASGPRQ
>CP029618.1|AZM47076.1|3680955_3681576_-|hypothetical-protein
MSKSEGPMGGFEERLLGELKQVVAARAAEEGATARPVAVAARAPRPRRRMWAGLTASVGAAAAGAAALVALPAMGGSAAYAVETNDDGTVTATIKEFTDAEGLERQLEEHGVSAEVDYVEWGQECQPERGESATRDFLLKQGAPPPEADGPYTFTVRPADFKPGETLVLETTLEWQGDAITGMGWGFQLVTGPVAPCNPTAIPDED
>CP029618.1|AZM47085.1|3692011_3692389_-|hypothetical-protein
MQEEIARSAIDMFISAFNASDESYVTALLSQALTSDVVFWGPLGRSEGIEAVERFVLDIRRHPAGAGTMVRCSAVDMPGEWARYQWVFTAPDGGPRLAGTDVVHLRRSLIDQVIVFAGEIEPSAS
>CP029618.1|AZM47086.1|3693126_3693318_-|hypothetical-protein
MPDITWEQPFCQDSGNCFRIGTDAEGNAHIAVAGREEHRVTDSVEALRMLIRDIKAGKADHLL
>CP029618.1|AZM47087.1|3693329_3694181_-|transcriptional-regulator
MPPRSNPTARQRRLGAELRKLREAAGLSTEQAAAVLATNRTVITSTEAGRHGISPERVRRLACNYECADPELVDALVRMAADRTRGWWEDFRGVLPPTFLDIAELEWFATALRMATMTHIPGPFQTEAFARALFDAAIPPLPADEFDARVAHRVRRHEALTRPDGPAYTALVHEAALRTEVGGRKVLREQLQHVLAMADHENVTVRAIPFSAGAIPGSGQALLYADGDVPSLDTVQLDRTNAAEFLHLDGQLRKYRLHLDRMQQMSLPPAETRDLIHDLIHQL
>CP029618.1|AZM47088.1|3694421_3694856_+|ATP-binding-protein
MPPHLPTPTPPVPPLPVRCTFPAHPLSVPRARRAVLDALPRPQHPRLGDDLQLLASELVTNAVRHGTRPDSDHLIELFLWPADGHYWLAVSDPGPGTPSLTAPSTTDCGGRGLLLVDALSAAWAVVPRRVCGKAVVAGLPLGLR
>CP029618.1|AZM47089.1|3694890_3695358_-|NUDIX-hydrolase
MSFRLAAYAVCIEDGRVLLARHVPPQGESNWTLPGGRVEHGEDPFDAVTREVAEETGCAAVVERLLGVDSRVIPAADARAGVEHQNVGIFYRVRITGGRLRPEPDGDIAESVWTAVADVAGLRRSSLVDIGLALARTLPATGHVPPVRVGGLIGH
>CP029618.1|AZM47090.1|3695507_3696101_+|shikimate-kinase
MAEGSASTAPTLLYIVGPPAVGKATVGHEIATRTGLRLFHNHMAIEPVLRFFDFGSPAFVRLVDGFRQGLIEEVAASDLPGLIFTYVWAFDQPDDERALEQYALPFRERGGRVLYLELKASQEARLQRNSGASRLAEKPSKRDLDASQRRLLAMDERHRLNSTTEFQDRTDYLRIDNTHLSPEDVAKQVIKQFSLDG
>CP029618.1|AZM47091.1|3696977_3697430_-|hypothetical-protein
MRPTAKKGLVAAGVTAAALLATVAPAEAAPADKPQVLASFTQTSATSYNTWAAAEANRGAWSAYAFNWSTDYCSSSPDNPFGFPFQKACQRHDFGYRNYKEIGGFDANKSRLDSAFYEDLKRVCNRYSGATKTSCNSTAWVYYQAVRAFG
>CP029618.1|AZM50800.1|3697696_3698650_+|hypothetical-protein
MKRRSLLTGALAGAVAAPAAVTLGASKANAAVANYPIALTDQATNSFQVFDRTGDWSAASNWSFTPGTTNGWDDPFEIRFRATTRYGTIALMTAGQPGNGRAGIVAVTGNGNRLDRGDLIWEASVASYPHCIERIPNVAAVVVAGTRDRIHVYGGANSDHSTLREVQTITDMPKPHAVLWDDVNDLLWVTGGTVIRTYRVTGANSTARLVKSGTDITFAGNGHDIQPDYTDPGKLWVTDSGRVYSLDKATRKVTIISEENYVKSYVRYTDGEAMWTLDPTPADPPWGGPTVYFSGGQSKTRPGAQIYKARIVTTRFH
>CP029618.1|AZM47092.1|3698630_3699908_-|MFS-transporter
MTGLGADFRRLWLSSAVSNLGDGVRLTALPLLAAAVTRDPVAVAAVSVAAELPWLLVSLPAGALADRVDRRRLMVAVQLVRMCLAALLTATVLADRSSIAVLCAFVFLLGIGEVVYDAAAPTILPRIVPREQLTRGNARLFGVELGANEFAGPPLGGLLFRLGQAVPFVLDAVSFAASAALLSRLRGTFRPAGAADGPKAGVVRAIGEGFGWLWRNPVIRTLSVVVTFMNLARAMTMAVFVLYALETLDLSAVGYGVLSSAVAVGAVAGSWAAERIRPAAAGPCLVAAVLGHGLTTVAMGATSNPWVAGASSAGFGFATMTWSVLTAAVRQTVVPDRLLGRISSVHRFLSWGSLPLGSLLGGVLAAAYGLRVPFAAGGAAVVLAALVAARTLLGVSALLAGPGGAGGVGGVDGAGEAGGVSGSGS
>CP029618.1|AZM47093.1|3701821_3702664_-|hypothetical-protein
MNWWKKLRTALAGGDKHTAPWCDACRRRVPGGVTKAPPPGVLSPFYVGAPGRVGSTVVREACDDCWRRHRELTAEGEADYRRTHPVEKYVAALRHRKLSVREDAARVLSTLRDPRAVAPLIAAIRSETDHPRVERSYYVSALMFALADTGGEEARDFLDGLLRAPASWRELHRPDFYPLIPAVDWVAPALAVLGDTVMLRPLLDLLAEDRPDRVRRMTARHLVRLTNGGAGRWSVDGPVVCEITPQGRRMFTEGMRAAADDADETVRGYATTALAHVGAW

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Crispr_ID: CP029618_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP029618_4

4522327-4522409

Orphan

Consensus_repeat	Method
GGGGGAGGAGCCGCCGGCGCCCGCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP029618_4

>merge|CP029618|4|4522327-4522409|CRISPRCasFinder
GGGGGAGGAGCCGCCGGCGCCCGCGGCGGTGGCGGCGGTCAGGCGGAGGGGAGCCGGGGGGAGGAGCCGCCGGCGCCCGCGGC

>CP029618|4|4|4522327-4522409|CRISPRCasFinder
GGGGGAGGAGCCGCCGGCGCCCGCGGC	GGTGGCGGCGGTCAGGCGGAGGGGAGCCG
GGGGGAGGAGCCGCCGGCGCCCGCGGC

Protein	Signature genes	Signature genes Name	Protein_function
CP029618.1\|AZM47709.1\|4517307_4520052_-\|carbohydrate-binding-protein	unknown	unknown	gnl\|CDD\|371140
CP029618.1\|AZM47719.1\|4534058_4534508_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|224647
CP029618.1\|AZM47718.1\|4532941_4533868_-\|NADPH:quinone-reductase	unknown	unknown	gnl\|CDD\|176191
CP029618.1\|AZM47711.1\|4521847_4522207_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|240572
CP029618.1\|AZM47715.1\|4529793_4531233_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227601
CP029618.1\|AZM50872.1\|4527893_4528385_+\|DUF1877-domain-containing-protein	unknown	unknown	gnl\|CDD\|378105
CP029618.1\|AZM47707.1\|4516120_4516822_+\|branched-chain-amino-acid-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224215
CP029618.1\|AZM47706.1\|4515599_4516058_-\|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
CP029618.1\|AZM47716.1\|4531357_4532266_+\|LysR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|182183
CP029618.1\|AZM47714.1\|4527001_4527349_-\|hypothetical-protein	unknown	unknown	unknown
CP029618.1\|AZM47703.1\|4506499_4508932_-\|glycosyl-hydrolase	unknown	unknown	gnl\|CDD\|369642
CP029618.1\|AZM47705.1\|4511617_4513966_-\|alpha-L-fucosidase	unknown	unknown	gnl\|CDD\|379625
CP029618.1\|AZM50873.1\|4529285_4529720_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|378915
CP029618.1\|AZM47710.1\|4520155_4521796_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|365906
CP029618.1\|AZM47713.1\|4525880_4527005_-\|site-specific-integrase	unknown	unknown	gnl\|CDD\|271189
CP029618.1\|AZM50870.1\|4514122_4515382_-\|xylosidase	unknown	unknown	gnl\|CDD\|211417
CP029618.1\|AZM47712.1\|4523265_4525380_+\|RNA-helicase	unknown	unknown	gnl\|CDD\|223587
CP029618.1\|AZM47708.1\|4516814_4517150_+\|branched-chain-amino-acid-ABC-transporter	unknown	unknown	gnl\|CDD\|224601
CP029618.1\|AZM47704.1\|4509089_4511390_-\|sugar-kinase	unknown	unknown	gnl\|CDD\|224851
CP029618.1\|AZM47717.1\|4532439_4532772_-\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
CP029618.1\|AZM47709.1\|4517307_4520052_-\|carbohydrate-binding-protein	gnl\|CDD\|371140	pfam10566, Glyco_hydro_97, Glycoside hydrolase 97. This domain is the catalytic region of the bacterial glycosyl-hydrolase family 97. This central part of the GH97 family protein sequences represents a typical and complete (beta/alpha)8-barrel or catalytic TIM-barrel type domain. The N- and C-terminal parts of the sequences, mainly consisting of beta-strands, form two additional non-catalytic domains. In all known glycosidases with the (beta-alpha)8-barrel fold, the amino acid residues at the active site are located on the C-termini of the beta-strands.	5.13815e-83
CP029618.1\|AZM47719.1\|4534058_4534508_-\|transcriptional-regulator	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	6.36265e-31
CP029618.1\|AZM47718.1\|4532941_4533868_-\|NADPH:quinone-reductase	gnl\|CDD\|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	3.7655e-87
CP029618.1\|AZM47711.1\|4521847_4522207_+\|hypothetical-protein	gnl\|CDD\|240572	cd12952, MMP_ACEL2062, Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein. The subfamily includes an uncharacterized protein from Acidothermus cellulolyticus (ACEL2062) and its homologs from bacteria. Although its biological role remains unclear, ACEL2062 contains a minimal metalloprotease (MMP)-like domain consisting of 3-stranded mixed 2-beta sheets and a HExxHxxGxxD/S (x could be any amino acid) motif. It may belong to a superfamily of bacterial zinc metallo-peptidases, which is characterized by a conserved HExxHxxGxxD motif.	1.02194e-47
CP029618.1\|AZM47715.1\|4529793_4531233_-\|hypothetical-protein	gnl\|CDD\|227601	COG5276, COG5276, Uncharacterized conserved protein [Function unknown].	2.36331e-18
CP029618.1\|AZM50872.1\|4527893_4528385_+\|DUF1877-domain-containing-protein	gnl\|CDD\|378105	pfam08974, DUF1877, Domain of unknown function (DUF1877). This domain is found in a set of hypothetical bacterial proteins.	2.68138e-39
CP029618.1\|AZM47707.1\|4516120_4516822_+\|branched-chain-amino-acid-ABC-transporter-permease	gnl\|CDD\|224215	COG1296, AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism].	7.43529e-38
CP029618.1\|AZM47706.1\|4515599_4516058_-\|Lrp/AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.25986e-37
CP029618.1\|AZM47716.1\|4531357_4532266_+\|LysR-family-transcriptional-regulator	gnl\|CDD\|182183	PRK09986, PRK09986, LysR family transcriptional regulator.	2.06224e-61
CP029618.1\|AZM50873.1\|4529285_4529720_+\|hypothetical-protein	gnl\|CDD\|378915	pfam12680, SnoaL_2, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.000569259
CP029618.1\|AZM47703.1\|4506499_4508932_-\|glycosyl-hydrolase	gnl\|CDD\|369642	pfam07995, GSDH, Glucose / Sorbosone dehydrogenase. Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	6.98432e-34
CP029618.1\|AZM47705.1\|4511617_4513966_-\|alpha-L-fucosidase	gnl\|CDD\|379625	pfam14498, Glyco_hyd_65N_2, Glycosyl hydrolase family 65, N-terminal domain. This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.	2.38953e-63
CP029618.1\|AZM47710.1\|4520155_4521796_-\|hypothetical-protein	gnl\|CDD\|365906	pfam00149, Metallophos, Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.	7.0552e-10
CP029618.1\|AZM47713.1\|4525880_4527005_-\|site-specific-integrase	gnl\|CDD\|271189	cd01189, INT_ICEBs1_C_like, C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons. This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.	1.66209e-16
CP029618.1\|AZM50870.1\|4514122_4515382_-\|xylosidase	gnl\|CDD\|211417	cd11576, GH99_GH71_like_2, Uncharacterized glycoside hydrolase family 99-like domain. This family of putative glycoside hydrolases resembles glycosyl hydrolase families 71 and 99 (following the CAZY nomenclature) and may share a similar catalytic site and mechanism. The domain may co-occur with other domains involved in the binding/processing of glycans.	0
CP029618.1\|AZM47712.1\|4523265_4525380_+\|RNA-helicase	gnl\|CDD\|223587	COG0513, SrmB, Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis].	1.85542e-117
CP029618.1\|AZM47708.1\|4516814_4517150_+\|branched-chain-amino-acid-ABC-transporter	gnl\|CDD\|224601	COG1687, AzlD, Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism].	1.64668e-19
CP029618.1\|AZM47704.1\|4509089_4511390_-\|sugar-kinase	gnl\|CDD\|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	8.56495e-44

>CP029618.1|AZM47711.1|4521847_4522207_+|hypothetical-protein
MGHVLDMSNEEFEELVAQALDRIPAELTRLMDNVAVFVEPEPPPDDPGLLGLYEGTPLTERGEWYAGVLPDRITIYRGPTLRMCESREDVVAETEITVVHEIAHHFGIDDDRLHALGYG
>CP029618.1|AZM47710.1|4520155_4521796_-|hypothetical-protein
MAREVPFAVSPVRALFERLRRAPARLRRFPAAVRRLADRARGARRAHPPRAPRRRRVESSLVQRPHPYARALGLAAVTVVGAGLGLLVVGGVETSVGPVDTRMALTPSVTGDTRISVSPLGAIDMDSHDAPLRLDVEVERLDPDRSRALVAHPEEFSGLEEEVAADIRRSTVDLGVRSGGAALVGATALGLAVYRTPRRALAAGGLALALLAASGASAFATWNPKSVLEPKYSGLLTSAPSVIGDARSIVTEFDVYQQELARLVTNVSKLYDAASTLPAYRPDPSTVRFLHVSDMHLNPAAWGIIRSLVDQYELDAVIDTGDTMDHGSEAENVYLDPIATLGVPYVWVRGNHDSLATQAAVERQKNARVVDDGESVVVAGVRIAGIGDPQFTPDRSVAAAGDPAETAAGERLAAALAGLRDRGRPADLAIAHNPVALEEVDGLVPLALAGHRHNRKQHDLPDGTRLMVEGSAGGGGLRAVEQDVPEKVSASVLYLDRSTRRLQAWDEITLGGLGLTSAEVSRHLVEENQPGGADGTDPSGAPGEDS
>CP029618.1|AZM47709.1|4517307_4520052_-|carbohydrate-binding-protein
MPLFGPLGRRPAGTMLTAFTVLATAWLSPAAATPVPDPPTPTATTSDVWTVAPPQGNKDQLAADVVRDDATGALTLTVRRGGDVVLPDSPLGLRTKGADLTRGLDVLGRDDRSLRERYAMTTGKQRRVDSPMTESRFALRGDGGVRMDLVVRVARDGVAFRYELPDSEGTVVTGEASGYRLPADAPAWLLPHTSWYEEVRGETTAGGAAADDYGYPALFEVAADDYVLLTESGMDSTYPGSKLAHAAGGGAYDVALAEAEVVSPGDLATPWRTAIVGDLATVTESTLVSDLAPDAEFSDTSWIRPGTVSWSWLVEHDSPRDFERQKDYVDYAAAHGWEYTLVDEGWSREWVPELVRYARTKGVDILLWFRWWEVDTPQEMDTVFGELNDWGVKGVKVDFMNSGGGEPEGVGRHAWYEDVLAATAEHKLLVNFHGATLPKGLQRTWPHLMTYEAVRGHEYYSFNQPLTPTYNTMLPFTRNVVGSADVTPGTFSMTNRTHSDAHELALPVVYESGLQHPADSPETYATLPEAERVLDQLPTVWDETRYLGGRPGDGAVLARRAGDRWFVGGIHAGAAGTSEVDVGRLGADDGERLLVELVTDGADGLARETRRVGGDARLTVPVAENGGFVAVVCAAENGRSTCDEPVRTTPATGLAITPDSATVSPGDEIEVTGRFAAADGESATLRNVTLGARPRAGWTAAGEDVARPALRPGQAVSGSWTVRVPESAEPGYVDVPVVAEYRASGADPAEPRVHVERAVRVLVAPPVPQGEAHVGDLHLLTASNGWGPVEIDTSVGDDGAGDGAPLTIGGTTYAKGLGAHAPSRVTVYLGGACTSFAAQAGVDDEVGDRGSVSFRVLGDGTELTTTGTLRGTDAAQSVTADVTGVDLLTLEVADGGDGISYDHADWADPKVTCG
>CP029618.1|AZM47708.1|4516814_4517150_+|branched-chain-amino-acid-ABC-transporter
MPDAPAAGYLLAAVAVAVAVTWALRALPFAALAPLRSSPLVAYLDAAMPVGVMVILAAYTLRHLTPRDPGAAWPTVLALAATVAVHLWRRNVLLSILGGTAVHVVLASAVF
>CP029618.1|AZM47707.1|4516120_4516822_+|branched-chain-amino-acid-ABC-transporter-permease
MPHQLRADLSRALADSGSVGLGAFPMGVAFGVLVVHSGLDWWWASVFSGLIYAGSLEFLFLGLVLAAAPLGQIALTAFTVNFRHVFYALSFPLHRVRGGAARAYSTFALSDEAYAVTAHPAAQSYPGRRVLWLQVFIHLYWAGGATTGALLGAAVPAGVEGLDFAVTALFTVLALDALRDRPGLAVPALALCCALAARFAVPGGQLFAAFVLFAAALLARYAAVRRREAGARA
>CP029618.1|AZM47706.1|4515599_4516058_-|Lrp/AsnC-family-transcriptional-regulator
MSNERKLDELDREILRQLQRDGRLTNVELARRVGLTPPPCLRRVKRLEEAGIITGYRARVDEEAAGRGLEVIVSIEVSVSDLDTLAGLEATIGAYDEVVEFRRVFGTPDYFLRVLVADYAAYERFQTGKIIGIPGVARVISQPTMKKIKVVD
>CP029618.1|AZM50870.1|4514122_4515382_-|xylosidase
MLSGTAASAAAAGGVFSTRLAGAAEEPAAAAKAGARPAASPVGDVVGKVTVGYQGWFACPGDGAPINGWWHWSRDMSRPPSPDNTTIASWPDMREYENTYPTAYANLNGGGPATLFSSWDDQTVDTHFRWMAEHGCDTAALQRFNPFGGEGATRDGMAAKVRAAAEKHGRKFYIMYDVTSWTQMQSQIKEDWTTKMKAYTSSGAYAMQNGKPVVCIWGFGFNDDGRPFTPGPCLDVVNWFKNQGCYVIGGVPTHWRTGQSDSRPGFLDVYHAFHMISPWMVGRISDTGGADHFAANVNGPDKADCDAHGIDYQPCVIPGDLQSGHRAHGDLMWRQFYHLVRLGVAGVYISMFDEYNEANQIAKTAENASQVPSGSGIRALDEDGTSCSSDYYLRLTADGGRMLKGQLALTPNRPTPPRP
>CP029618.1|AZM47705.1|4511617_4513966_-|alpha-L-fucosidase
MSGDITRRTTVKSALAAAGALTLGTPALAYAARRAAADPGDTWRLWYDKPAADWERESLPLGNGALGVGVFGTLASERLTLNEKTLWTGGPGSGGGYDFGNWRDPRPGALKAVQDRLDAEGRLSPETVAQQLGQSKHGFGAYQILGELLLDHPSAPGAPDGSYWRDLDLAEGVAAVAYAHQGADHRREYFVSHPDGVAVGRLTASLPGRVAFTLRYASPRNDFQATASGDRLTIRGTLQDNGMVFEAQIRLLTEGGSVSSGNGTLTVSGANSAWFVLAAGTDYAGTYPDYRGADPHDRVTGAVDRAVQTGHGALRQRHVADHRGLFDRVALDIGQQQPAQPTDRLLAGYGSGSAADRALEALFFQYGRYLLIASSRPGSTPANLQGVWNNVTNPPWSADYHVNINLQMNYWPAEITNLAETTVPYDEFVEALRAPGRVSAREIYATGGWVVHNETNPFGFTGVHDWASSFWFPEAAAWLTQQMYEHYRFDGSTDYLRNTAYPVMKEAAEFWLANLRTDPRDGKLVVTPSYSPEQGDFTAGCSMSQQIVYDLLTSTLEAAQTLGDSPDFRTRLEQTLAALDPGLRIGRWGQLQEWKADLDDQNNDHRHVSHLFALHPGRQIEVGSQWAEAAKVSLTARGDGGTGWSKAWKINFWARLTDGDHAHKMLSEQLKSSTLPNLWDTHPPFQIDGNFGATSGIAEMLLQSQHGPIEVLPALPGAWPSGSVRGLRARGGATLDITWSGGRATRIALHANRTRRLTLRSDLLPGGEQVVDAVAGQTYTFG
>CP029618.1|AZM47704.1|4509089_4511390_-|sugar-kinase
MHPHKQATVTAAAPPSAAVPAARPSAEDTGLLREWAAEGGALELRARIVLLAGQGMRDTDIARRLGVSRQTVGAWRHKWADEGIAGLRHRARPGRPATVDEAEVIARTLLASDGAAASRAVGRELGLSHATVAAIRRRWSDHPPADPPLPGADIWVVGLYADAHGAVLLTGARTGPAAQPRPAGSAVGADVLARLDRACDALPGAVAGSRTPAPHRALAAFLTKARRRHPRIELHALTLWTADPADVHPHASPPAAPGPAPAPPAVRPEASPPATLHGIPATCTWRSYLRALVALDSSRHPESSRRVYLDLAGAVEAYARHPAGEPLQWLRESIASHAAPPRPRGRSGGGAGTGRRETVGGANHIDLGSFNECVVIEAVRLAGTVTRGEIAHRTGLTQQSVSRIARSLLARGILVEENRRQATSGKPRTPVRLRGEAAHAVGIHIDPEVFTAVVIDLDGTIVAERTRPVHPTADPDVLVRQVAHLGRGVLADARGAVRPGGFLGIGVAVPGPVDTDSGTVLDPPLMSVWTDLPLLYLLKDHFQCPLIMEKDAAAAAAGERWIGRDRRARDFAYVYLGTGVGSGLYLNGDLHRGTSANAGEFGQLCAVALGRTGPGGRPEVLPECNPPLGLSRLAARHGFPLDAGLAGTTAGYRAVTEAAAAGDPAATAAVRDLARAVGQGTTSLVDLLDIDLVVLGGPFFTDPAAPLYLSHIGEMVNDFPTARRLRHVDVERSVLGSEAAAVGAASTIFHAAFTPRLRGGTALRAL
>CP029618.1|AZM47703.1|4506499_4508932_-|glycosyl-hydrolase
MDRPGRAPRLLAVLALVLGGGAVAAGSPAAGETAGIPPGDYQHVQLAAGPAEMGEPMSLAVLPDRSVVHTARDGTVRVTDAAGNTKVAGKLDVYSHDEEGLQGVAADPGFATNRQLYLYYSPTLNTPPGDAPATGGPADFEPWKGHLNLSRFTLRPDNTLDPGSEKVILEVPNDRGQCCHVGGDIDFDAQGNLYLTTGDDTNPFASGGYSPIDERAGTNPQFDAQRSSGNTNDLRGKVLRIKPTADGYTVPSGNLFAPGTPETRPEIYAMGFRNPFRMSVDRETGVVYLGDYGPDAGGSDPDRGPGGQVEFNRITGPGNYGWPYCTGTNTAAETYNEFTFPDGPSGAKYDCGGGPVNNSPHNTGQDKLPPAKPAWIRYGGDAGSPPEFGGGSESPMGGEVYRYDPDLDSDVKFPESLDGRYFAGELGRQWIKAIEVGQDGSPGLIEDFPWDGTQVMDTDFGPDGALYVLDYGSGGGNQALYRIEYLAGSNRNPVAQAAADRTSGGTPLTVRFSSAGSADPEGGALTYRWDFGDGATSDQANPSHTYTSAGTFTPTLTVTDPEGLTGTASLVVTAGNTAPTVTLRTPGDGRLFSFGDDVPFTVVASDPEDGAVDCAKVRVAYALGHDSHTHEITSANGCSGTIIVPEDGEHDTAANLYGVFKAEYTDSGGLTGTSTRTLQPRHRQAEHFGAMSGIQIAGHGGAEGGATVGFTDDGDWVSFEPYALDDVTGVSARVASGGPGGTIEVRTGSPAGGLLGTLTVPPTGGWENYQEVSASLTAAPPGATTLYLRFAGPTGQGNLLDIDAFTFTTG
>CP029618.1|AZM47712.1|4523265_4525380_+|RNA-helicase
MLAPALDEAETSEVTEITEAPETAAADGTGDTAVTGDAPEAAAPTFGDLGLPRGVVAKLADYGVTTPFPIQAATIPDALAGRDVLGRGRTGSGKTLSFGLPLLATLAGGHTDPKRPRGLILTPTRELAMQVADALQPYGDVLRLSMKVVCGGTSMGRQIGALERGVDVLVATPGRLRDVIDRGACSLDRVQIAVLDEADQMADLGFLPEVTELLDQVPPGGQRMLFSATLDKGVGTLVERYLVDPVSHEVDPSAGAVTTMTHHVFVVKPRDKAPVTAAIAARKGRTIVFVRTQLGADRVADQLRETGVRAAALHGGMTQGARTHTLADFKDGRVHALVATDVAARGIHVDGIDLVLNVDPAGDHKDYLHRAGRTARAGESGTVVSLALPHQRRTVFRLLEDAAVDASRHIISGRGAFDPDVARITGARSIDEVQAESAAQAATAAERDVTQLEAQLERARKHAADLRAEATRLATRAGVTPEQPASAASTAEQAGADAGAETAPAEPRSEARSYDARADRGYDRADRNGTRQDRREQRFREFDRSGDSRRTDREYPRRDNRDGRETRDYRNDRRDDRRDDRSYDRRDDRPSYDRRDDRSYGTREPRSYDRRDTRRDDRGTRPYDRGTRSYPRRDDRGAARPYDRDNRRPYERRDSADRSRFGGDRPAGRDRRDGRPYSHDRRTTDDRRTDKPRWKRQDRNNRKG
>CP029618.1|AZM47713.1|4525880_4527005_-|site-specific-integrase
MKGSTYKRCKCPAVYDAKGRRKNCRKDHGAWYYVADVGFGPDGKRKQMRKGGFRTADDAEAALAELLERVNKGTYTHDEGTTVAAWLEQWLEKKARAGLRASTLRSYRGHVEQHLIPHLGRLRLRDLRPPHVDRLLVDLDNGKRKAATIRRVHATLRSALSTAVRQRLVTFNAAKDIELPKAKRPKARPWEPDELGAFLDHIGTHRLGTLYEVIAGTGLRRGEAVGLRWDDIDLANRVIVVRQQVVQESGRKKNKQAPAPCPYCEPGHLGVSFGKPKTASGEDRVVDLDEGTVGALIAHKLRQDTERVQWGEAYADHGLVFPREDGNPLRPDDVSKLFADLVNEVRFDDDAHLPDEERRRLRRVRLHDLRHGQA
>CP029618.1|AZM47714.1|4527001_4527349_-|hypothetical-protein
MICLTMTGETGWEVGAAPIRLYQSHHGAVSSWHAAERGVRRMGLSEEHARAELSKTRARYEDRLREIRSDLRERDLLVPPLPPELRHVDDDRAGEFGGFDEFHSTIEESSGGDVR
>CP029618.1|AZM50872.1|4527893_4528385_+|DUF1877-domain-containing-protein
MNGEYLRVTPAELARAVKDPDWAFEYVMEIMETDGINDVAPSDARQLTTHKAFDAIAFLLERASFPVDIVHGEQTFTSEDWGYGPAKYLDADQVKLAAEALASLSFEDLIRDVDPEQMTAAQIYPLLWDEADALEWVREWFDPLAPFFGAAAQAGEAMLVWLD
>CP029618.1|AZM50873.1|4529285_4529720_+|hypothetical-protein
MDAFDRGWRTGDWSRFLAMLTDDFGFWFPESPARGRFEGGAGRQAVAEWTAFHAANGNRVLGTRRRTTVAGDRVFYEYDSVGASANTAAYRNWEFIVIEVSGNRIRALQEYWGDARPTAGGAVGAPQAPAPRRDGRSTAHPAAS
>CP029618.1|AZM47715.1|4529793_4531233_-|hypothetical-protein
MSRRQALRASTALAGAAGMSAAAPGLGGAARAGTGEPGDATVRPPRGAYARNVEVVGYCDLEERPGFKMSVKEKNGRWYLYTGHFWHPGWSVVDVTDPARARVLDWLPAPGHPGNTVANQVTLHGDTMITAMEKAPELPPYYDPTQPFHEGILLWDISDPVRPRRLAQWTSNGTGTHRNLYAGGRYAHLSAAMPGFTGNIYVILDISDRERPTIAGRWWVPGQENGGATPQQDDDGGPHHHGFCCGNGAHVHLHGPPYPVGSLVYLPYGSAGLIVLDISDVSRPRQIGHLPFSPPFHAQFGVHGVLPIPDKGIAFANSEDISYGTGPAHHASVIDISDPTAPVLLSLLPEPVPPEDAPYDDFHTRGGWCGPHNMNHHLYSGDVQQFNGLFYLAHFNAGLRVYDVTHTRSPRETGYFIPPEPRKRYGTLPAPRKGEPAEALPVLQTEDVVVDRRGFIYITDKNQGMWILRYVGPAPGSRA
>CP029618.1|AZM47716.1|4531357_4532266_+|LysR-family-transcriptional-regulator
MPDLRRMEYFVAVAEELSFTGAARRLHMSQPPLSMQIQQLEREIGVPLLDRSRRRVALTAAGEVFLEEARATLRQVARAAELARDAARGEAGRLDVGVVDAALYSLVPPIVRRFTELYPRVELSVSARRMDEQIELVSAGGLDVGFVHPPVAHAELAVEAAYTEPCVLVAPEDHPLAGSGPVPLAEIVAYPLIGPPRSVNPSAHDSVFAYCHERGLYPEIVREASPKQAIVALVAAGLGVSLLPAALMNHPHPGVVYRPVDDDGFGITTSLLWRRDDARPATLAFLEVARELRTSVADSAPS
>CP029618.1|AZM47717.1|4532439_4532772_-|hypothetical-protein
MGKYLAILNGAADEADKAEFTEEQQTEFMNAWAAWAQKNEHRLVDPGAPLFRKKMVTAKGVEDFTDSKTGYAIVEATSHEAAAALFSDHPHIGLVAGNSIEVIECPPVPG
>CP029618.1|AZM47718.1|4532941_4533868_-|NADPH:quinone-reductase
MPRAVRFDGYGDVDVLRVVDVERPVPGPDEVLVRVRAAGINPGESAIREGLFDAMWPATFPSGQGSDLAGVVEELGEQVQNVAVGDEVIGFTDRRASHAEYVAVPAANVTPRPPGVPWEAAGALPVVGTTAYAAVRAVGAGPGDTVVIAGAAGGVGTLASQLARNAGATVIGLAGPDHSDWLAAHGITPVAYGEGVADRVRGAAGDGGPNAFIDTFGADYVRMAVEDLGIRPDRVNTLINHADAQRYGTRTDGNAQGASADVLAELAAGIADGDLEVPVARTYPLEQVRDAYRELERRHTLGKIVLVP
>CP029618.1|AZM47719.1|4534058_4534508_-|transcriptional-regulator
MQRTRFGEMACSIARTLDVIGEPWSPLILRDVWAGVHRFDHIQADLGISRKVLTERLNHLVGQGVLERLPYDARPRYEYHLTDKGADLVEMLMVMARWGDRWLAGEAGPPVLYRHHACGQIGHVDPRCSRCGEPMHAGDVDLLPGPGSA

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Crispr_ID: CP029618_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP029618_6

6784735-6784818

Orphan

Consensus_repeat	Method
TCCCCTCACACCCACCCAAGGTATGCGCC	CRISPRCasFinder

1 spacers

DEDDh

The CRISPR arrays of CP029618_6

>merge|CP029618|6|6784735-6784818|CRISPRCasFinder
TCCCCTCACACCCACCCAAGGTATGCGCCGGGTCTGATGCGCCCCTTCCCGTACGTCCCCTCACACCCACCCAAGGGTATGCGC

>CP029618|6|6|6784735-6784818|CRISPRCasFinder
TCCCCTCACACCCACCCAAGGTATGCGCC	GGGTCTGATGCGCCCCTTCCCGTACG
TCCCCTCACACCCACCCAAGGGTATGCGC

Protein	Signature genes	Signature genes Name	Protein_function
CP029618.1\|AZM49393.1\|6797625_6798375_+\|DNA-polymerase-III-subunit-epsilon	DEDDh	cd06127_DEDDh_CAS-I	gnl\|CDD\|181176
CP029618.1\|AZM49391.1\|6793897_6794122_-\|DUF397-domain-containing-protein	unknown	unknown	gnl\|CDD\|377231
CP029618.1\|AZM49385.1\|6775773_6776442_-\|histidine-phosphatase-family-protein	unknown	unknown	gnl\|CDD\|366010
CP029618.1\|AZM51056.1\|6783246_6784023_+\|DeoR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
CP029618.1\|AZM49389.1\|6781729_6782806_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|380650
CP029618.1\|AZM51060.1\|6792891_6793782_-\|hydroxyurea-phosphotransferase	unknown	unknown	gnl\|CDD\|309685
CP029618.1\|AZM49390.1\|6791943_6792786_+\|proteasome-subunit-beta	unknown	unknown	gnl\|CDD\|163402
CP029618.1\|AZM51057.1\|6786333_6787512_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|99784
CP029618.1\|AZM49392.1\|6795386_6795977_+\|DNA-polymerase-III	unknown	unknown	gnl\|CDD\|99836
CP029618.1\|AZM49383.1\|6773537_6774728_-\|hypothetical-protein	unknown	unknown	unknown
CP029618.1\|AZM49382.1\|6773051_6773471_+\|peptide-methionine-(R)-S-oxide-reductase	unknown	unknown	gnl\|CDD\|376583
CP029618.1\|AZM49388.1\|6780772_6781618_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224053
CP029618.1\|AZM51061.1\|6794408_6795131_-\|trypsin	unknown	unknown	gnl\|CDD\|214473
CP029618.1\|AZM49384.1\|6774748_6775777_-\|hydroxyacid-dehydrogenase	unknown	unknown	gnl\|CDD\|240648
CP029618.1\|AZM49387.1\|6779525_6780776_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|226669
CP029618.1\|AZM51059.1\|6790360_6791584_-\|hypothetical-protein	unknown	unknown	unknown
CP029618.1\|AZM51062.1\|6796313_6797468_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|376148
CP029618.1\|AZM51058.1\|6787644_6788100_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
CP029618.1\|AZM51055.1\|6776438_6777983_-\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|198346
CP029618.1\|AZM49386.1\|6777979_6779521_-\|carbohydrate-kinase	unknown	unknown	gnl\|CDD\|212666

Protein	Function_ID	Function_description	E-value
CP029618.1\|AZM49391.1\|6793897_6794122_-\|DUF397-domain-containing-protein	gnl\|CDD\|377231	pfam04149, DUF397, Domain of unknown function (DUF397). The function of this family is unknown.	6.34392e-23
CP029618.1\|AZM49385.1\|6775773_6776442_-\|histidine-phosphatase-family-protein	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	8.74612e-63
CP029618.1\|AZM51056.1\|6783246_6784023_+\|DeoR-family-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	9.1239e-73
CP029618.1\|AZM49389.1\|6781729_6782806_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|380650	cd19995, PBP1_ABC_xylose_binding-like, periplasmic xylose-like sugar-binding component of the ABC-type transport systems. Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type 1 periplasmic binding protein (PBP1) superfamily, which consists of two alpha/beta globular domains connected by a three-stranded hinge. This Venus flytrap-like domain undergoes a transition from an open to a closed conformational state upon ligand binding. Moreover, the periplasmic xylose-binding protein is homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR.	2.0109e-121
CP029618.1\|AZM51060.1\|6792891_6793782_-\|hydroxyurea-phosphotransferase	gnl\|CDD\|309685	pfam04655, APH_6_hur, Aminoglycoside/hydroxyurea antibiotic resistance kinase. The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation utilising ATP. Likewise hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety.	1.15802e-36
CP029618.1\|AZM49390.1\|6791943_6792786_+\|proteasome-subunit-beta	gnl\|CDD\|163402	TIGR03690, 20S_bact_beta, proteasome, beta subunit, bacterial type. Members of this family are the beta subunit of the 20S proteasome as found in Actinobacteria such as Mycobacterium, Rhodococcus, and Streptomyces. In Streptomyces, maturation during proteasome assembly was shown to remove a 53-amino acid propeptide. Most of the length of the propeptide is not included in this model. [Protein fate, Degradation of proteins, peptides, and glycopeptides].	1.56685e-112
CP029618.1\|AZM51057.1\|6786333_6787512_-\|hypothetical-protein	gnl\|CDD\|99784	cd06187, O2ase_reductase_like, The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD/NADH domain and/or discrete) to the oxygenase. Dioxygenases add both atoms of oxygen to the substrate, while mono-oxygenases (aka mixed oxygenases) add one atom to the substrate and one atom to water. In dioxygenases, Class I enzymes are 2 component, containing a reductase with Rieske type [2Fe-2S] redox centers and an oxygenase. Class II are 3 component, having discrete flavin and ferredoxin proteins and an oxygenase. Class III have 2 [2Fe-2S] centers, one fused to the flavin domain and the other separate.	1.07156e-54
CP029618.1\|AZM49393.1\|6797625_6798375_+\|DNA-polymerase-III-subunit-epsilon	gnl\|CDD\|181176	PRK07942, PRK07942, DNA polymerase III subunit epsilon; Provisional.	5.66693e-93
CP029618.1\|AZM49392.1\|6795386_6795977_+\|DNA-polymerase-III	gnl\|CDD\|99836	cd06133, ERI-1_3'hExo_like, DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins. This subfamily is composed of Caenorhabditis elegans ERI-1, human 3' exonuclease (3'hExo), Drosophila exonuclease snipper (snp), and similar proteins from eukaryotes and bacteria. These are DEDDh-type DnaQ-like 3'-5' exonucleases containing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific Hx(4)D conserved pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. ERI-1 has been implicated in the degradation of small interfering RNAs (RNAi). 3'hExo participates in the degradation of histone mRNAs. Snp is a non-essential exonuclease that efficiently degrades structured RNA and DNA substrates as long as there is a minimum of 2 nucleotides in the 3' overhang to initiate degradation. Snp is not a functional homolog of either ERI-1 or 3'hExo.	1.94782e-65
CP029618.1\|AZM49382.1\|6773051_6773471_+\|peptide-methionine-(R)-S-oxide-reductase	gnl\|CDD\|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	2.4069e-76
CP029618.1\|AZM49388.1\|6780772_6781618_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	8.49446e-101
CP029618.1\|AZM51061.1\|6794408_6795131_-\|trypsin	gnl\|CDD\|214473	smart00020, Tryp_SPc, Trypsin-like serine protease. Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.	1.84773e-31
CP029618.1\|AZM49384.1\|6774748_6775777_-\|hydroxyacid-dehydrogenase	gnl\|CDD\|240648	cd12171, 2-Hacid_dh_10, Putative D-isomer specific 2-hydroxyacid dehydrogenases. 2-Hydroxyacid dehydrogenases catalyze the conversion of a wide variety of D-2-hydroxy acids to their corresponding keto acids. The general mechanism is (R)-lactate + acceptor to pyruvate + reduced acceptor. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence. While many members of this family are dimeric, alanine DH is hexameric and phosphoglycerate DH is tetrameric.	8.68306e-139
CP029618.1\|AZM49387.1\|6779525_6780776_-\|ABC-transporter-permease	gnl\|CDD\|226669	COG4214, XylH, ABC-type xylose transport system, permease component [Carbohydrate transport and metabolism].	5.40438e-98
CP029618.1\|AZM51062.1\|6796313_6797468_+\|hypothetical-protein	gnl\|CDD\|376148	pfam18725, HEPN_SAV2148, SAV2148-like HEPN. SAV2148-like HEPN nuclease domain.	1.90933e-119
CP029618.1\|AZM51058.1\|6787644_6788100_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	0.000130384
CP029618.1\|AZM51055.1\|6776438_6777983_-\|carbohydrate-kinase	gnl\|CDD\|198346	cd07768, FGGY_RBK_like, Ribulokinase-like carbohydrate kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of ribulokinases (RBKs) and similar proteins from bacteria and eukaryota. RBKs catalyze the MgATP-dependent phosphorylation of a variety of sugar substrates including L- and/or D-ribulose. Members of this subfamily contain two large domains separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. Members of this subfamily belong to the FGGY family of carbohydrate kinases.	1.61672e-86
CP029618.1\|AZM49386.1\|6777979_6779521_-\|carbohydrate-kinase	gnl\|CDD\|212666	cd07802, FGGY_L-XK, L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases. This subfamily is composed of bacterial L-xylulose kinases (L-XK, also known as L-xylulokinase; EC 2.7.1.53), which catalyze the ATP-dependent phosphorylation of L-xylulose to produce L-xylulose 5-phosphate and ADP. The presence of Mg2+ might be required for catalytic activity. Some uncharacterized sequences are also included in this subfamily. L-XKs belong to the FGGY family of carbohydrate kinases, the monomers of which contain two large domains, which are separated by a deep cleft that forms the active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain.	1.08291e-138

>CP029618.1|AZM51056.1|6783246_6784023_+|DeoR-family-transcriptional-regulator
MSGRKPRERRDRIKGRVVDEGFVRIEQLADELGVTPMTIRRDLDHLQSRGWLRKVRGGATAQPSTAFHGDVRHRTQAMTAEKNALARAALPLVKSGQSVIIDDSTTALALTRLLTQQAPLTVITNFVPVTQVLAGSPGIELISLGGTYYPAYDAFLGLRTVDAVTSLYADTLFASTTAITRGHCYHQSQETVAVKRALMEACARKILLVDHTKFRRHGLYQLAPVTAFDLVIVDSGIPPGDLDALQADGVEVLVAHPE
>CP029618.1|AZM49389.1|6781729_6782806_-|ABC-transporter-substrate-binding-protein
MRRLASFALAGILATGALTACAEEPGSSGDDGEGGGTGAGKVAFLMPDLASTRYEQYDAPLFKKRMGELCDECKVIYQNADSDAALQQQQANSAMAQGAKVIVLDPVDSESAATIVQTAQSQGVKVIAYDRPIPTKPADFYVSFDNEAIGESIGQSLVDHLDKESAEGGILQVNGSPTDAAAGLIKKGIHNAVDDSGYKLLAEYDTPDWSPEKAQQWVSGQISQYSGRIAGVVAANDGTGGGSIAAFKAAEAQVPPVTGNDAELAAVQRIIAGDQYNTISKPIKTVAEAAAEVTYAFMQGEKPKADTELFDTPSQLFEPTVVTQENLKEVIFGPDGVLKAEDVCTRAYAKDCKSLGIG
>CP029618.1|AZM49388.1|6780772_6781618_-|ABC-transporter-ATP-binding-protein
MTAPAAPAAPTVLSLRGVSKQFGAVAALTGIDLDVAAGEVVAVVGDNGAGKSTLVKILSGVYTPDGGTITFHDREVSLGSPADAQAIGIATVFQDLALCENLDVKANLFLGQELRPWMLDDVRMETRSWELLRELSARIPTLDVPVAALSGGQRQTVAITRALLGKPEVILLDEPTAALGVAQTAEVLNLIERLKGNGLGVVMISHNMDDVRAVADRVAVLRLGRNNGVFDARAVTSEQVVAAITGAVDNVVAQRAARRAAAGEPRPDAATRNERKEKELP
>CP029618.1|AZM49387.1|6779525_6780776_-|ABC-transporter-permease
MTSLDTPPSKTTDLMDERLTTPQGIGDSVRAAVRRTRDGDLGMLPVVAGIVVIWTIFQSLNQTFLSSTNLVNLAFEMVPLGVIALGIVCVLLVGQIDLSVGSVSGVSAAATAVVMVKHEQPMVLALTVAIAGGCVIGWLYGQILNRFGVPSFVVTLGGLLAFLGLQLWLLRDQNAINIPYDSPLVKFAQVWFVPEALAYVFAVAAAGGFLAVGWVRARSRRRAGLSSASMQWLGLQAGLLAAALLFTVFYLNRTRGVPWMFMLFVSLVLMVHYVLTKTKFGRSLYAVGGNAEAARRAGIDVRAVYTSAFVMCSALAATGGVLAAARLAAANQSTGTADVNLNAIAAAVIGGTSLFGGRGSAFAALLGVLVIQSISSGLTLLNLDSSYRFIITGLVLLVAVALDSAARRSRQAHGRG
>CP029618.1|AZM49386.1|6777979_6779521_-|carbohydrate-kinase
MGEADLTALAIDAGTTVVKVVGYGPDGAELTVGRRPTRVTRPRPGWAEQDMTDVWDAVASAVREVVAALPAPPAFVAVTGQGDGAWLIDGAGRPTGPAVLWNDGRAAGIVGDWERDGTVDEAFRICGSRLSTGMPNAVLAWLRAHDPDRAARSRHLLTCGGWLFYKLTGLPAVDESEAAAPFLDISGRTWSDRLFELYGVEWARELLPPLRDDDHRVTPLGAAAGAETGLPEGIPVVLAPYDICATAIGSGAVSAGRACTILGTTLSTEIVTDAPPAPGPADTPVGITVPLGVPGHYLRAFPTMSGGDMLDWGARLLGLSSAAELMELAERGSAGTAGVRFMPYLSPAGERAPFFDPAARGSLTGLSLDSGREDVARAVVEGVTLAIRDCLAASPAEPGLLTLSGGGTRSGFWMRLISDVTGVPVAVPADTEIGARGAWLTGAVATGREPDFATAAAHQVRIAASYEPDPARAADGRYAEFLELRELHRPVWALGRERTAGGTGSAHAGGAGA
>CP029618.1|AZM51055.1|6776438_6777983_-|carbohydrate-kinase
MTHPAPDAWLGIDLGTQGVRAVAADSAGHLLGTGTAPLTSDRRDGRHEQDPDEWWRAVCAAVGEARAAGADPRRIRAVAVDATSGTVTLTDRRGCAVTPALMYDDGRAAAEAEKVNEAGEAQWTRAGYRRMQRSWGLPKLRWLLDRHPRAAADGWRLAHQNDVVNRRLVGHDVPADTSNALKTGADAATVTWPDEVFADLGIPAEVLPGLVSPGTVLGEVSAAAAAETGLLAGTPVVAGMTDGCAAQLGSGATAVGSWNSVMGTTLVLKGVTADLVHDPAGVMYSHRSPAGTWLPGGASSVGAGLVAREFAGADLDRLTAGAAELLPTGLLRYPLVSPGERFPFVAPEATAFRSREAAGPAEDFAALLQGAAYVERLCFDYADLLGAPATGAVVLTGGATRNPVWNQLRADVLRRPVTLPRHAQPALGMAVLAAAALDGTGTATGSGGAAGSPAAGGALDRAAAAMVRADRTVEPRDPYRSAHDEGYVRLVDLLARRGWLPEVVAAHARERTAS
>CP029618.1|AZM49385.1|6775773_6776442_-|histidine-phosphatase-family-protein
MSLNVIFVRHGESVWHGENRYAGATDIDLTDHGRDQAAALADWAAQAGLTAVWSSPMLRCRQTAAGSAAAAGLPLHLDPRLRELDFGVAEGLTRAEMRERMPEAVASFEADPVAGHFPEGEDPAAVVERYAAFLADLRAEHDTGAQGDGKQAGGKESDGRILVVAHSTAIRLTLCRLLGLPLRDYRRRFPYLANCALNELVLSDGTPSLLTLNRPVTPGVPA
>CP029618.1|AZM49384.1|6774748_6775777_-|hydroxyacid-dehydrogenase
MTTILAAGDHFVRNDLLRDRLRPVAPDADVRELTLPWPVEPFGPVAEVKEASGTEDQLIEALDGVEICVTQMAPLTERILAASPALRLFCVSRGGPVNANLDAATRHGVAVTYAPGRNATATAEHTVALMLAAARRVPATHADLAAGVWRGDYYRYEAVGPELEGSTVGIVGYGAIGSRVARIARGFGARVLVADPFADAAAVAPDELVELPELMNRSAFVTVHARATPQTEGLISRELIGLMPAGGVLVNCARGSLVDYDAVCDALDEGRLFGAAFDVFPVEPLPADSRLPRTPGVVMTPHLAGASRQTAHNAAGMVATEVGHHLAGRPLIHCANPEVRNR
>CP029618.1|AZM49383.1|6773537_6774728_-|hypothetical-protein
MRGKYRTARAAVVAGIAVPALLLTAAPAGFAAATAPAAAPAAKPLPSDLPTHIEGGAWPTSHVQGVTVDTERGFVYWSFTQMLVKTDLDGNVIGTVEGLTGHLGDIDLNNRDGRVYGSLEYKAEEAFYIAVFDVDKIDRVGMNAETDGVMTAVHLDEVVEDFTADMNGDGVFDGDTANTPDHRYGCSGIDGVSFGPEFGKRGGVQKLMVAYGVYSNTTRADNDHQVILEYDVRDWRRYERPLSQAEPHRSGPKRTDGKYFAYTGNTTYGVQNLQYDPYTRNWIMAVYDGVKEGFPNYSFFTVDGSKKPVRGEIKGQAKPEEGKLLTLRDAGLNDPATGVRGWEFHGNYGIDALGDGRYYVAEGRAVTEDGVRKQEGEVYLYRWTGETPTPFARVED
>CP029618.1|AZM49382.1|6773051_6773471_+|peptide-methionine-(R)-S-oxide-reductase
MTYEVDKPDEQWRAELSPEEYRVLRRAGTEPAFTGEYTDTKTEGVYECRACGAELFRSTEKFESHCGWPSFYDPAQSEAVELLEDRSLGMARTEVRCARCGSHLGHVFSGEGYPTPTDQRYCINSVSLRLLPAGESTGR
>CP029618.1|AZM51057.1|6786333_6787512_-|hypothetical-protein
MRASFARVERRADHVAKYFYSHLFARNPGVRELFPADMSEQRDRLFAALTHVVQRLDDPDLPRYLATLGRDHRKFDARPEHYAAVGESLIAALRFGLPNTWDEETEQAWLGAYKILSEAMIGGSEEADKRQAPRWWDCRVVARHAAAPGVTVLTLLPDRTLPYAAGQFVSVSTPKVPRVWRPYSIGCAPRADRTIDLHVSRVDGGLLSPVLVDRTAPDDTLRLGSPAGTAVLPKRAGRPVTFIAAGTGWAPIRALLEEMVRRWTPTTARLFLVARSPAHVYDPEAVDALRKHHSWVDVTVITPEGVERQGATAHRLEAALSAHRDWAKHRVYVSGPAQFIAEVRELVRGYGTPPEQIAHDHVPSPERAPREPGHSAWFLHPSQPQWINPADR
>CP029618.1|AZM51058.1|6787644_6788100_-|GNAT-family-N-acetyltransferase
MAWLTGQGRTDQWGTEPFSGLPERVAQMEEYARDFLVRVAETPEGGVAGVCVLADEPQSFVPAAGEPELYVRLLVTDRALRGAGVGAALVADARAEAVRRGVGLLRVDCFGGGDGALARQYERLGFTPSGTFTVERPGRPVWPGRLLEIRL
>CP029618.1|AZM51059.1|6790360_6791584_-|hypothetical-protein
MAGLTAEEDPAAPPPPGVGPGPARTALVAAIGELLGTAPPPRREPVGAELFDTLLRAGDRAVETGGERELLLAVALADTGVSLRAKSRAAWRLRARALDALGHAAAATEAYERTLALGSTHPETPVLLSMAREKRACLATAVGLFPADTAGGRETGAGEEGGGAEAGAASAASATGPAFAAAVRAEAMPGVVREAFTAYVTEQMSRYGAGDARVRELAGAYGTYCRILDQGRMADPLLAGARPVGVADFRGLVAGKTACVVVGPGRFEEAGDYELVVRCDDFRGGERADVHAVADPACASWHRPAGVRLLFADPGETWRETVRRAVPGAQDGLGDASLRRPLQDPALLGDGGWGPETSAAFTVLRLLDHLDVSPRLDVHGAGRLRPEERRWITSRAKDRTKTRTALR
>CP029618.1|AZM49390.1|6791943_6792786_+|proteasome-subunit-beta
MEQLPPEFLTPGSSSFVDFLAAHAPDQLPANRPLPGTATGTGAAAVDIPHGTTIVAASYADGVLLAADRRVTLGNGMIAHRDFEKVFPADEFSAVGIAGSTGMAEEMVRLLRLELEHYEKIETVPLSLEGKANRLGTLIRDNLGPAMQGLAVVPLFAGYDPRSGAARIYSYDITGGRAEEKGFGGTGSGSVFARGALKKLYREGMSRDDAVTMAVQALYDAAEDDSATGGPDATRRIYPLVYTVTAEGCRRLDDDRVSELSLAVLEGRRGRPDGPNAPLA
>CP029618.1|AZM51060.1|6792891_6793782_-|hydroxyurea-phosphotransferase
MRVHASGRAWLAELPDLVEKLRARWSLRLGAPFTGGSCSWVAPARLPDGTDAVFKVTWPHREAAGEAEGLRIWDGRGAVRLLAHDPGHYALLLERCKPGTELGTAGELGAEHRLRLGAEVLRELWSAPVPQDCGLERVADVCAEWADLLQERMERLRPGYDAGLVAHGARLLRELPGGARREVVVHGDFNPGNILAAGRRPWLAIDAKPMTGDPGYDPFPLLEQIDDPFATADPARTVAARLALLAGELGEDTGRLAAWAVARRVEAALWSAEHGDVPGGAGVLGEARLLAEVAGV
>CP029618.1|AZM49391.1|6793897_6794122_-|DUF397-domain-containing-protein
MTAWNDRFDLSDARWRKTSYSDRTGTACLEVADGFHPALVPVRDSKDPHGPALVFTATAWEAFVDGVKSGDFGA
>CP029618.1|AZM51061.1|6794408_6795131_-|trypsin
MLAALAFGTTAVAADHTSARGAADVTAAAQARTPEGPPSTKIIGGGYAQSGPWAARLFSNGRQTCSASIIAPTWILTAKHCVSGGGLSFRIGSLDQTSGGTLANGVQTYTHSSDLALVRLDRSVSTTYATLGQPGSVTVGQNVQVYGWGATSQCGSEINCQSQYLKVANVTVTGGCTDAYGGNAICARRGDGITAGGDSGGPMMANGVQVGVASTSDRQTTTAYTNVTRYRSWIQSIAGV
>CP029618.1|AZM49392.1|6795386_6795977_+|DNA-polymerase-III
MTTHLLDRVLVVDVEATCWEGPPPAGMSPEIIEIGLCELDVRTGQRLSRRSVLVRPEHSEVGDFCTRLTTLTPEQVAAGVPFAEACALLRREHGARQRVWASWGDYDRRQFERQCAAAEVAYPFGRRHVNAKTLYALAHGLGRELGMAEALAHAGQELEGTHHRGVDDAWNIAGLLAGVLWGGRTATAQEPPGGGA
>CP029618.1|AZM51062.1|6796313_6797468_+|hypothetical-protein
MEIGAEIGWGQDDWDEVRTRAARAGRAYIWLNVVEQRLRSVVASVLRPVYEPVHGEDWVVAAAGPAGQEWVQRAVAVREVSRRKGYLLDPADDNVISFLTLPQLRELMVQHWPCFEPYLDDRRDLELALDELEVARNVVSRNRALSGTVLAQAERAASRLLRLLGADDQPPSADRLPVDAVEDLVGDRYADVVGVHPDRVGLQRALPAEDLFGGARRLDAIGIGLNLLVQNYSGRRLGRLAEGGCRIRLLFLNPASSTVRRRERELGMKRGELARAVETNIIHMRRVRSRLRPQGGGDAAGSFEIRVFDETPRFTAYLIDGDRPDGLGVVQTYLRRARGAEAPALVLRAARRELVHGEGGGEPGLFEVYREEFESFWTDARPVS
>CP029618.1|AZM49393.1|6797625_6798375_+|DNA-polymerase-III-subunit-epsilon
MGWYGELLVGFDLETTGTDPGEARIVSAAVVEAVRGVPARRREWLADPGVPVPPETTAIHGITDERATAHGRPAAEVADEVAEALAAHWTRGVPVVAYNATFDLTLLAAELRRHGLASMRERLGGGEEGPVIDPYAMDRTVDPFREGKRTLEAVCVEYGVVLGRAHDAAEDALAAVRLAVAIAERYGDVASAGAWDLHRGQAGWHAERAEGYRQWLARQTRDAATAPMPGAATAEPVPERGYGPDGAVA

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP029618_4	4.1\|4522354\|29\|CP029618\|CRISPRCasFinder	4522354-4522382	29	CP029618.1	4522299-4522327	0	1.0

1. spacer 4.1|4522354|29|CP029618|CRISPRCasFinder matches to position: 4522299-4522327, mismatch: 0, identity: 1.0

ggtggcggcggtcaggcggaggggagccg	CRISPR spacer
ggtggcggcggtcaggcggaggggagccg	Protospacer
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MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP029618_4	4.1\|4522354\|29\|CP029618\|CRISPRCasFinder	4522354-4522382	29	MH271298	Microbacterium phage Floof, complete genome	10836-10864	5	0.828
CP029618_4	4.1\|4522354\|29\|CP029618\|CRISPRCasFinder	4522354-4522382	29	NC_016587	Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence	314272-314300	6	0.793
CP029618_4	4.1\|4522354\|29\|CP029618\|CRISPRCasFinder	4522354-4522382	29	NZ_CP007796	Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence	489930-489958	6	0.793
CP029618_4	4.1\|4522354\|29\|CP029618\|CRISPRCasFinder	4522354-4522382	29	NZ_CP016313	Thermus brockianus strain GE-1 plasmid pTB1, complete sequence	24809-24837	6	0.793
CP029618_4	4.1\|4522354\|29\|CP029618\|CRISPRCasFinder	4522354-4522382	29	NZ_CP032347	Azospirillum brasilense strain MTCC4039 plasmid p2, complete sequence	638636-638664	7	0.759
CP029618_4	4.1\|4522354\|29\|CP029618\|CRISPRCasFinder	4522354-4522382	29	NZ_CP030128	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed2, complete sequence	254996-255024	8	0.724
CP029618_4	4.1\|4522354\|29\|CP029618\|CRISPRCasFinder	4522354-4522382	29	NZ_CP022363	Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence	357860-357888	8	0.724
CP029618_3	3.1\|3691086\|33\|CP029618\|CRISPRCasFinder	3691086-3691118	33	NC_008537	Arthrobacter sp. FB24 plasmid 1, complete sequence	34421-34453	10	0.697

1. spacer 4.1|4522354|29|CP029618|CRISPRCasFinder matches to MH271298 (Microbacterium phage Floof, complete genome) position: , mismatch: 5, identity: 0.828

ggtggcggcggtcaggcggaggggagccg	CRISPR spacer
ggtggcggcggtcaggaggagctgcgcgg	Protospacer
**************** ****  * ** *

2. spacer 4.1|4522354|29|CP029618|CRISPRCasFinder matches to NC_016587 (Azospirillum lipoferum 4B plasmid AZO_p4, complete sequence) position: , mismatch: 6, identity: 0.793

ggtggcggcggtcaggcggaggggagccg	CRISPR spacer
tcgggcggcggtccgtcggaggggagcgg	Protospacer
   ********** * *********** *

3. spacer 4.1|4522354|29|CP029618|CRISPRCasFinder matches to NZ_CP007796 (Azospirillum brasilense strain Az39 plasmid AbAZ39_p3, complete sequence) position: , mismatch: 6, identity: 0.793

ggtggcggcggtcaggcggaggggagccg	CRISPR spacer
cttggcggcggtcaggcggcgggcggcgg	Protospacer
  ***************** *** .** *

4. spacer 4.1|4522354|29|CP029618|CRISPRCasFinder matches to NZ_CP016313 (Thermus brockianus strain GE-1 plasmid pTB1, complete sequence) position: , mismatch: 6, identity: 0.793

ggtggcggcggtcaggcggaggggagccg	CRISPR spacer
gatggcggcggtgaggcggaggtgatcgt	Protospacer
*.********** ********* ** *

5. spacer 4.1|4522354|29|CP029618|CRISPRCasFinder matches to NZ_CP032347 (Azospirillum brasilense strain MTCC4039 plasmid p2, complete sequence) position: , mismatch: 7, identity: 0.759

ggtggcggcggtcaggcggaggggagccg	CRISPR spacer
cttggcggcggtcaggcggcgggcgacgg	Protospacer
  ***************** *** ..* *

6. spacer 4.1|4522354|29|CP029618|CRISPRCasFinder matches to NZ_CP030128 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.724

ggtggcggcggtcaggcggaggggagccg	CRISPR spacer
aatggcgacggtcaggcggaggtgacgtc	Protospacer
..*****.************** **  .

7. spacer 4.1|4522354|29|CP029618|CRISPRCasFinder matches to NZ_CP022363 (Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence) position: , mismatch: 8, identity: 0.724

ggtggcggcggtcaggcggaggggagccg	CRISPR spacer
cttggcggcggtcaggcggcgggcgatgg	Protospacer
  ***************** *** ... *

8. spacer 3.1|3691086|33|CP029618|CRISPRCasFinder matches to NC_008537 (Arthrobacter sp. FB24 plasmid 1, complete sequence) position: , mismatch: 10, identity: 0.697

ccccgatcgccgatcccctcggcggacgggggg	CRISPR spacer
gccccatcgccgatctcctcggcggcgctgaaa	Protospacer
 *** **********.*********    *...

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3016987 : 3034569

Streptomyces_phage(91.67%)

capsid,terminase

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZM46563.1\|3016987_3019744_-	hypothetical protein	D7NW64	Streptomyces_phage	9.3e-131	37.7
AZM46564.1\|3019774_3022924_-	hypothetical protein	A0A2H5BLG0	Streptomyces_phage	5.8e-44	53.7
AZM50735.1\|3022976_3023189_-	hypothetical protein	NA	NA	NA	NA
AZM46565.1\|3023185_3023743_-	hypothetical protein	NA	NA	NA	NA
AZM46566.1\|3023742_3024213_-	hypothetical protein	A0A162E1H6	Gordonia_phage	6.9e-10	29.3
AZM46567.1\|3024225_3024657_-	hypothetical protein	NA	NA	NA	NA
AZM50736.1\|3024727_3025039_-	hypothetical protein	A0A1V0E617	Streptomyces_phage	1.4e-22	58.9
AZM46568.1\|3025091_3025406_-	hypothetical protein	A0A1J0MC76	Streptomyces_phage	3.3e-16	43.0
AZM46569.1\|3025399_3025822_-	hypothetical protein	K4IBG7	Streptomyces_phage	5.8e-16	52.2
AZM46570.1\|3025837_3026347_-	hypothetical protein	NA	NA	NA	NA
AZM46571.1\|3026364_3026922_-	hypothetical protein	NA	NA	NA	NA
AZM46572.1\|3026918_3027386_-	hypothetical protein	NA	NA	NA	NA
AZM46573.1\|3027382_3028447_-\|capsid	phage major capsid protein	A0A1V0E621	Streptomyces_phage	1.1e-74	44.2
AZM46574.1\|3028460_3029288_-	hypothetical protein	A0A1J0MD42	Streptomyces_phage	3.5e-17	49.0
AZM46575.1\|3029832_3030972_-\|capsid	capsid protein	A0A1J0MCS2	Streptomyces_phage	1.4e-85	51.6
AZM46576.1\|3030975_3032529_-\|capsid	capsid protein	A0A1J0MCN7	Streptomyces_phage	1.1e-93	41.3
AZM46577.1\|3032515_3032749_-	hypothetical protein	NA	NA	NA	NA
AZM46578.1\|3032750_3034037_-\|terminase	PBSX family phage terminase large subunit	A0A1J0MC90	Streptomyces_phage	2.2e-143	62.7
AZM46579.1\|3034026_3034569_-	hypothetical protein	A0A1J0MCI5	Streptomyces_phage	1.8e-22	43.0

DBSCAN-SWA_2

3052537 : 3056770

Streptomyces_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZM46603.1\|3052537_3052840_-	hypothetical protein	A0A0M4QZK4	Streptomyces_phage	5.0e-14	52.3
AZM46604.1\|3052836_3053415_-	hypothetical protein	A0A0M3UKC6	Streptomyces_phage	1.9e-25	51.7
AZM46605.1\|3053411_3053660_-	hypothetical protein	NA	NA	NA	NA
AZM50740.1\|3053661_3054642_-	DNA cytosine methyltransferase	G1DUR4	Mycobacterium_phage	1.2e-67	41.3
AZM46606.1\|3054641_3055142_-	hypothetical protein	K4JU53	Streptococcus_phage	3.8e-06	31.5
AZM46607.1\|3055134_3055431_-	hypothetical protein	NA	NA	NA	NA
AZM46608.1\|3055427_3056141_-	DNA polymerase III subunit epsilon	Q1WDI5	Streptomyces_phage	2.1e-58	50.0
AZM50741.1\|3056140_3056770_-	hypothetical protein	A0A1B0XTM7	Freshwater_phage	8.6e-16	34.8

DBSCAN-SWA_3

4575852 : 4591805

Streptomyces_phage(75.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZM47750.1\|4575852_4577364_-	hypothetical protein	A0A1J0GVT2	Streptomyces_phage	7.7e-103	37.2
AZM47751.1\|4577360_4577552_-	hypothetical protein	NA	NA	NA	NA
AZM47752.1\|4577554_4577827_-	hypothetical protein	G8I4P7	Mycobacterium_phage	5.9e-14	62.7
AZM47753.1\|4577823_4578291_-	hypothetical protein	NA	NA	NA	NA
AZM47754.1\|4578299_4578593_-	hypothetical protein	NA	NA	NA	NA
AZM47755.1\|4578854_4579328_-	HNH endonuclease	A0A1J0MCC0	Streptomyces_phage	2.1e-19	48.4
AZM47756.1\|4579324_4579840_-	hypothetical protein	NA	NA	NA	NA
AZM47757.1\|4579849_4580104_-	hypothetical protein	A0A2L1IVL5	Streptomyces_phage	2.6e-27	64.3
AZM47758.1\|4580258_4580543_+	hypothetical protein	NA	NA	NA	NA
AZM47759.1\|4580600_4580891_-	hypothetical protein	NA	NA	NA	NA
AZM47760.1\|4580893_4581658_-	N-acetylmuramoyl-L-alanine amidase	K4HYE4	Streptomyces_phage	1.3e-71	62.7
AZM47761.1\|4581657_4582245_-	hypothetical protein	NA	NA	NA	NA
AZM47762.1\|4582220_4582529_-	hypothetical protein	A0A142K8R1	Gordonia_phage	1.2e-18	46.5
AZM47763.1\|4582543_4583332_-	hypothetical protein	NA	NA	NA	NA
AZM47764.1\|4583436_4584048_-	hypothetical protein	NA	NA	NA	NA
AZM47765.1\|4584204_4584606_-	hypothetical protein	NA	NA	NA	NA
AZM47766.1\|4584607_4584856_-	hypothetical protein	NA	NA	NA	NA
AZM47767.1\|4584965_4585217_-	hypothetical protein	NA	NA	NA	NA
AZM47768.1\|4585218_4585521_-	hypothetical protein	A0A1J0GVW1	Streptomyces_phage	6.8e-11	47.1
AZM47769.1\|4585517_4586087_-	hypothetical protein	A0A1J0GVW0	Streptomyces_phage	4.6e-24	40.7
AZM47770.1\|4587076_4587325_-	hypothetical protein	NA	NA	NA	NA
AZM47771.1\|4587328_4587697_-	hypothetical protein	NA	NA	NA	NA
AZM47772.1\|4587814_4588099_-	stage V sporulation protein S	A0A1J0GVV0	Streptomyces_phage	6.0e-09	43.8
AZM47773.1\|4588163_4588724_-	hypothetical protein	H9EB76	Vibrio_phage	8.5e-07	31.2
AZM47774.1\|4588725_4589193_-	hypothetical protein	NA	NA	NA	NA
AZM47775.1\|4589189_4590098_-	hypothetical protein	A0A1J0GVW6	Streptomyces_phage	3.5e-42	38.9
AZM47776.1\|4590079_4590445_-	hypothetical protein	NA	NA	NA	NA
AZM47777.1\|4590444_4590759_-	hypothetical protein	NA	NA	NA	NA
AZM47778.1\|4590758_4591805_-	hypothetical protein	A0A1J0GVZ1	Streptomyces_phage	8.0e-83	47.9

DBSCAN-SWA_4

4619111 : 4628592

Streptomyces_phage(75.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZM47804.1\|4619111_4619975_-	hypothetical protein	A0A1J0GW46	Streptomyces_phage	3.9e-43	34.4
AZM47805.1\|4620001_4620586_-	hypothetical protein	A0A1J0GW41	Streptomyces_phage	1.3e-55	57.8
AZM47806.1\|4620657_4622664_-	hypothetical protein	A0A1J0GW47	Streptomyces_phage	3.9e-94	35.7
AZM47807.1\|4622660_4623341_-	hypothetical protein	A0A1J0GW36	Streptomyces_phage	9.5e-45	46.6
AZM47808.1\|4623564_4623807_-	hypothetical protein	NA	NA	NA	NA
AZM47809.1\|4623879_4625079_-	hypothetical protein	A0A097EYK8	Mycobacterium_phage	2.2e-07	31.6
AZM47810.1\|4625175_4625385_-	hypothetical protein	NA	NA	NA	NA
AZM47811.1\|4625384_4626368_-	hypothetical protein	A0A0K0N6P9	Gordonia_phage	1.5e-30	38.8
AZM47812.1\|4626509_4627136_-	hypothetical protein	A0A1J0MCV7	Streptomyces_phage	3.5e-17	48.0
AZM47813.1\|4627149_4627755_-	hypothetical protein	NA	NA	NA	NA
AZM47814.1\|4627761_4628592_-	hypothetical protein	A0A1J0GW50	Streptomyces_phage	3.2e-66	50.5

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP029618

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection