CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP034451	Mesorhizobium sp. M3A.F.Ca.ET.080.04.2.1 chromosome, complete genome	6 crisprs	csa3,RT,cas3,WYL,DEDDh	0	1	2	0

1. CP034451

CRISPR-Cas detection and classification

Crispr_ID: CP034451_1

• CRISPR_ID: CP034451_1
• CRISPR_location: 1048198-1048314
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of CP034451_1

Consensus_repeat	Method
AATGCTCAAGCCCGTAAGCGGGCTTGAGTGGCGGCATGGATTTC	CRISPRCasFinder

spacers of CP034451_1

>1.1|1048242|29|CP034451|CRISPRCasFinder
CAAGGAAATCCATAAGCCCATCGACCAAC

CRISPR arrays and Neighbor proteins around CP034451_1

CRISPR arrays

The CRISPR arrays of CP034451_1

>merge|CP034451|1|1048198-1048314|CRISPRCasFinder
AATGCTCAAGCCCGTAAGCGGGCTTGAGTGGCGGCATGGATTTCCAAGGAAATCCATAAGCCCATCGACCAACAATGCTCAAGCCCGCAAGCGGGCTTGAGTGGCGGCATGGATTTC

>CP034451|1|1|1048198-1048314|CRISPRCasFinder
AATGCTCAAGCCCGTAAGCGGGCTTGAGTGGCGGCATGGATTTC	CAAGGAAATCCATAAGCCCATCGACCAAC
AATGCTCAAGCCCGCAAGCGGGCTTGAGTGGCGGCATGGATTTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP034451.1|AZO08520.1|1038563_1039499_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|224759
CP034451.1|AZO08525.1|1045129_1045933_+|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|369777
CP034451.1|AZO12887.1|1040910_1042191_-|FAD-binding-protein	unknown	unknown	gnl|CDD|130740
CP034451.1|AZO08529.1|1049447_1049807_-|YkgJ-family-cysteine-cluster-protein	unknown	unknown	gnl|CDD|223799
CP034451.1|AZO08521.1|1039777_1040914_-|DSD1-family-PLP-dependent-enzyme	unknown	unknown	gnl|CDD|143489
CP034451.1|AZO08519.1|1036929_1038423_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|227903
CP034451.1|AZO08534.1|1052284_1053433_-|metallophosphoesterase	unknown	unknown	gnl|CDD|227842
CP034451.1|AZO08536.1|1054066_1054660_+|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08530.1|1050004_1050784_-|ATPase	unknown	unknown	gnl|CDD|176856
CP034451.1|AZO08524.1|1044189_1045041_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08532.1|1051286_1051946_-|glutathione-S-transferase-family-protein	unknown	unknown	gnl|CDD|198303
CP034451.1|AZO08523.1|1043509_1044136_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|380058
CP034451.1|AZO08522.1|1042190_1043387_-|MFS-transporter	unknown	unknown	gnl|CDD|340882
CP034451.1|AZO12888.1|1054746_1055574_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
CP034451.1|AZO08527.1|1046513_1048166_+|chaperonin-GroEL	unknown	unknown	gnl|CDD|234573
CP034451.1|AZO08533.1|1052087_1052267_+|CsbD-family-protein	unknown	unknown	gnl|CDD|283241
CP034451.1|AZO08531.1|1050783_1051119_-|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
CP034451.1|AZO08528.1|1048391_1049003_-|LysE-family-translocator	unknown	unknown	gnl|CDD|224199
CP034451.1|AZO08526.1|1046147_1046444_+|co-chaperone-GroES	unknown	unknown	gnl|CDD|178988
CP034451.1|AZO08535.1|1053496_1053826_-|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP034451.1|AZO08531.1|1050783_1051119_-|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	6e-20	66.5	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP034451.1|AZO08520.1|1038563_1039499_-|GNAT-family-N-acetyltransferase	gnl|CDD|224759	COG1846, MarR, Transcriptional regulators [Transcription].	1.38194e-13
CP034451.1|AZO08525.1|1045129_1045933_+|methyltransferase-domain-containing-protein	gnl|CDD|369777	pfam08241, Methyltransf_11, Methyltransferase domain. Members of this family are SAM dependent methyltransferases.	6.48343e-07
CP034451.1|AZO12887.1|1040910_1042191_-|FAD-binding-protein	gnl|CDD|130740	TIGR01679, bact_FAD_ox, FAD-linked oxidoreductase. This model represents a family of bacterial oxidoreductases with covalently linked FAD, closely related to two different eukaryotic oxidases, L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae.	0
CP034451.1|AZO08529.1|1049447_1049807_-|YkgJ-family-cysteine-cluster-protein	gnl|CDD|223799	COG0727, COG0727, Predicted Fe-S-cluster oxidoreductase [General function prediction only].	2.6764e-09
CP034451.1|AZO08521.1|1039777_1040914_-|DSD1-family-PLP-dependent-enzyme	gnl|CDD|143489	cd06814, PLPDE_III_DSD_D-TA_like_3, Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3. This subfamily is composed of uncharacterized bacterial proteins with similarity to eukaryotic D-serine dehydratases (DSD) and D-threonine aldolases (D-TA). DSD catalyzes the dehydration of D-serine to aminoacrylate, which is rapidly hydrolyzed to pyruvate and ammonia. D-TA reversibly catalyzes the aldol cleavage of D-threonine into glycine and acetaldehyde, and the synthesis of D-threonine from glycine and acetaldehyde. DSD and D-TA are fold type III PLP-dependent enzymes, similar to bacterial alanine racemase (AR), which contains an N-terminal PLP-binding TIM barrel domain and a C-terminal beta-sandwich domain. AR exists as homodimers with active sites that lie at the interface between the TIM barrel domain of one subunit and the beta-sandwich domain of the other subunit. Based on their similarity to AR, it is possible members of this family also form dimers in solution.	2.71539e-161
CP034451.1|AZO08519.1|1036929_1038423_-|tetratricopeptide-repeat-protein	gnl|CDD|227903	COG5616, COG5616, Predicted integral membrane protein [Function unknown].	1.82399e-28
CP034451.1|AZO08534.1|1052284_1053433_-|metallophosphoesterase	gnl|CDD|227842	COG5555, COG5555, Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion].	0
CP034451.1|AZO08530.1|1050004_1050784_-|ATPase	gnl|CDD|176856	cd07814, SRPBCC_CalC_Aha1-like, Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins. This family includes the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of Micromonospora echinospora CalC, human Aha1, and related proteins. Proteins in this group belong to the SRPBCC domain superfamily of proteins, which bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket. MeCalC confers resistance to the enediyne, calicheamicin gamma 1 (CLM), by a self sacrificing mechanism which results in inactivation of both CalC and the highly reactive diradical enediyne species. MeCalC can also inactivate two other enediynes, shishijimicin and namenamicin. A crucial Gly of the MeCalC CLM resistance mechanism is not conserved in this subgroup. This family also includes the C-terminal, Bet v1-like domain of Aha1, one of several co-chaperones, which regulate the dimeric chaperone Hsp90. Aha1 promotes dimerization of the N-terminal domains of Hsp90, and stimulates its low intrinsic ATPase activity, and may regulate the dwell time of Hsp90 with client proteins. Aha1 can act as either a positive or negative regulator of chaperone-dependent activation, depending on the client protein, but the mechanisms by which these opposing functions are achieved are unclear. Aha1 is upregulated in a number of tumor lines co-incident with the activation of several signaling kinases.	4.02899e-37
CP034451.1|AZO08532.1|1051286_1051946_-|glutathione-S-transferase-family-protein	gnl|CDD|198303	cd03194, GST_C_3, C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases. Glutathione S-transferase (GST) C-terminal domain family, unknown subfamily 3; composed of uncharacterized proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. GSTs also show GSH peroxidase activity and are involved in the synthesis of prostaglandins and leukotrienes. The GST fold contains an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, with an active site located in a cleft between the two domains. GSH binds to the N-terminal domain while the hydrophobic substrate occupies a pocket in the C-terminal domain.	5.32777e-56
CP034451.1|AZO08523.1|1043509_1044136_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|380058	pfam17928, TetR_C_22, Tetracyclin repressor-like, C-terminal domain. TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor present in sco1712 proteins from Streptomyces coelicolo which act as a regulator of antibiotic production.	4.28858e-20
CP034451.1|AZO08522.1|1042190_1043387_-|MFS-transporter	gnl|CDD|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.36541e-09
CP034451.1|AZO12888.1|1054746_1055574_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	3.89461e-27
CP034451.1|AZO08527.1|1046513_1048166_+|chaperonin-GroEL	gnl|CDD|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
CP034451.1|AZO08533.1|1052087_1052267_+|CsbD-family-protein	gnl|CDD|283241	pfam05532, CsbD, CsbD-like. CsbD is a bacterial general stress response protein. It's expression is mediated by sigma-B, an alternative sigma factor. The role of CsbD in stress response is unclear.	2.96704e-09
CP034451.1|AZO08531.1|1050783_1051119_-|ArsR-family-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	7.29534e-19
CP034451.1|AZO08528.1|1048391_1049003_-|LysE-family-translocator	gnl|CDD|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	1.97652e-39
CP034451.1|AZO08526.1|1046147_1046444_+|co-chaperone-GroES	gnl|CDD|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	2.62057e-55

Protein sequences

>CP034451.1|AZO08527.1|1046513_1048166_+|chaperonin-GroEL
MAAKDVKFSRDARERMLRGVNILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQAIVQEGNKAVAAGMNPMDLKRGIDLAVGEVVGALGKAAKKIKTSEEVAQVGTISANGDESVGKMIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNADKMVADLEDAYILLHEKKLSNLQAMLPVLEAVVQTSKPLLIISEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVGLNMLGRAKKVSISKENTTIVDGAGKKAEIQGRVAQIKQQIEETTSDYDKEKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAVEEGIVAGGGVALLRASGNLKATGANSDQAAGINIVRRALQAPARQIAANAGAEASIVAGKILENKGATFGFNAQTGEYGDMIAMGIVDPVKVVRTALQDAASVAGLLVTTEAMIAEAPKKEAAGGMPGGMPGGGMGGMGGMDF
>CP034451.1|AZO08526.1|1046147_1046444_+|co-chaperone-GroES
MAKSKFRPLHDRVVVRRVESESKTAGGIIIPDTAKEKPQEGEIIAVGSGARDESGKLVPLDVKAGDRILFGKWSGTEVKLNGEDLLIMKESDIMGIIG
>CP034451.1|AZO08525.1|1045129_1045933_+|methyltransferase-domain-containing-protein
MTTHWDNYHRHWNSLEAPLRPTPETVGIFERELDPGEADVLLLGVTPELAGLGRTMLAVDGSAAMVSGVWPGDDARRRAITGNWLDLPIASASVGAVIGDGCLTVVGSARARHGLFGEVARVLKPGGRAAIRVFAGPETFEDLPSIKAQALAGEIGNFHALKWRIAMACATDDCDRAIGVQAIRDAFDNNFPDRAALAAASGWSLCSIETIDVYAGSETTYCFATLAMLVDEARDWFSDVRVVPSGSYPLAERCPLLVLGSPCQALR
>CP034451.1|AZO08524.1|1044189_1045041_-|hypothetical-protein
MARIIVITHEHDQFLGKRDILLRRGSPYLLFDILGQLKSRGHSIRIQQGLSKRHDADIAVLHVDATTTSADYLDYAGSFPFCLNVGAADISKRKISGALVSSGEVWQGPVIVKSNLNNQGIPETLLNRRAKRAGKSPPFPDVPVQRAYEVYASLGEVPDGIFGRDDLVVEKFIPEKEHDGFAARFWVFCGEHERCTRYVSPNSLVKASETIRREPVPVPDEMRERRRELGFDYGKFDFVMHEGKAVLLDANKTPGRPKNLVKMFAAGAAHLADGFEALMRKVV
>CP034451.1|AZO08523.1|1043509_1044136_+|TetR/AcrR-family-transcriptional-regulator
MREARRTATEPRRKPKQERSRERIDAILATTMRLIGEKGIDAVTMKEVGALAGGPIATVYHYFPSKSAILAMLYDRFAEESRARFATIIAEIRGLDDVTTAADRLLDDYCSRVAADPAIQDLQNAIQADKALQHLDIAETRRQADMFCTKVAPMLRADQREAFGRVVFLIFQLAGGVVRLALTQDEAEGRRTIEDYRSIIHAQLRLFL
>CP034451.1|AZO08522.1|1042190_1043387_-|MFS-transporter
MTVADAGQVEEGDWLVGNPTGLQLASALWIGSVGLLILGLQPVLLGALFSEGHVTGDELALVATAEMIAIAIGSGVVAMLLPARNMRGKSALLLLLLALANSWTAYAITASSLIAARAVAGLAEGGLVAVATELIARSRRAERIGGYFVTLQTLVQCALALLLALYVVPAMGASGGFIALGVVCLASLLVAWTVPDDYANLPKEEHFANVLTVPAITALLSILCYFMYFGAIWAFLEPLGAQFGIDGRTVGLMVSASLAAQVIGAMIATVFEARLDYRAAITIIGAVAVACSVLLASAPGFNAFWAATLVMGFILLFIVPYQIRLAITADDSRTAVLLVPAAQLLGLAIGPIAASLLIDGENFRPVPEFAAATALASVALLGVFVLVARRRSPASTAR
>CP034451.1|AZO12887.1|1040910_1042191_-|FAD-binding-protein
MANSWSNWSGLVKAAPKLIATPADVGELADLVRTAPGPLRVAGAGHSFTPLVQSDGTIISLEKIEGLVSHDAAHHQARVRAGTRLGALMRILQGIGQGLPNMGDIDRQAIGGALGTATHGSGSTLGAYHTQLEAVQFVDGQGKLCEFSRAGDQEMIHATGVALGAFGVLTELTLNNMPTYWLRRRKWVLPIGDMLREFEAMMAAHRSAEFYYIPFSGYAQFIASDLSDQPTTTRPTEDDEEGLATLRKLRTLLRRLPALRRALIKGAVKKVPSEDYVQDWLNVYASDRQTKFNEMEYHLPFEEGPKALAEIIELTEKHFPEVYFPMEVRSVAPDAFWLSPFHKRLTCSIAIHHDAANDPLPFMRAAEPIFRKYGGRPHWGKIHSLKAADFRKLYPRWDDAMAVRRDIDPGNRFVSPYMAGLFGIEQ
>CP034451.1|AZO08521.1|1039777_1040914_-|DSD1-family-PLP-dependent-enzyme
MSAYFTELSKALKAADIFRPCLVLDRDRLDANIALVKRRLAPGLAVRLVDKSLPCLPLLAHIASALGTSRFMTFHPPITQAVLDAFPEGDLLYGKPMPAGAARAALASGGAGWGSRVCWLIDTPERLAEYASLAAELSTELRFAFEVDIGLHRGGFASPSEIKAVTIPKRLRCAGIMAYEAHAPEIPGLFGGAEKALKQACAKAAEFVSALDLGQRSILNIGGSKTALLHGAAVANEVSIGSAFMLPGDFDTPGLDGFQPAAFIATPILKVVDPVLPGPAWLSKTLQALGLFPRWGCYLYGGKWMAEPVFPEGMKPNGFMGFSSNQQFMGLPAGADVRPSDYAFLRPTQSEAVLQHFGPIAVFAGGRIVEFWPVLPMG
>CP034451.1|AZO08520.1|1038563_1039499_-|GNAT-family-N-acetyltransferase
MTIHNRAGKDRIDVVRAFNRFYTRQIGLLDEGLLKSPFSLTEARVLYELAHHDGLVASDLVRDLGLDPGYVSRLLKKFEERGLVARAATEADARRSSIALTPAGREAFAPLNRDSHDQVRALLGRLAPADQDRLVKAMRLVQDLLGDRPEPKVPYVLRPLQVGDIGWITHRQGLIYAQDYGWDETYEALVAEILAAFVKNYDPKWERSWIAEREGEVVGSVFVMRKSPEVAKLRLLYVEHSARGLGIGRRLVDECIAFSRATGYKTLTLWTNDILGSARRIYQAAGFKLAEEERHHSFGKDLVGQTWNLQL
>CP034451.1|AZO08519.1|1036929_1038423_-|tetratricopeptide-repeat-protein
MTVATADQVFRFGGFTLDLAMGTLRGVNEPLFLRPKAYAVLSHLARNMGRVVPKSELMDVVWPGVYVTEDSLTQSVREIRKVLGEEMVRTVSKRGYMLAAEAEAAPEISTHPIVAVVRFRNESGDPADEAMVDGFAEDLINGVARFGTITVLARNSSFSFASFGRAEWPQIRARIGADYLVEGSLRRQGEHVVVAVSLVDIATASQLWGDRYQSHGEGLFAIEREIVEQIVSRLVTRVTNAGLEQASRKPVTSLAAYELALRGFALLRDPAQTDQRGAEALFEAAVAKDPNYGLAYTYLALARALDGEFGRASDSVLENARDLADKGLALSPDQPTGHRVQSLIRLYMRDHEAAEHHMRIALQLNPYDADSIEQMGMLLTMRGRPLEALTWLARGIRIDPLHPHWYQFDRALALYMMGEYRQAADALELATRPAPWIRTRLAACYAQMGDMEKARRQIVLIEEGEPFSPLDYALRGVPFENRADAEHLAEGVRLALG
>CP034451.1|AZO08528.1|1048391_1049003_-|LysE-family-translocator
MSIEFLLTSLIIVASPGTGVLYTLSAGLSRGARASIIAAFACTLGIIPHMAAAITGLAAVLHTSAVAFETLKYLGVAYLLYIAWNTLKEKGGLSVDERAAPRSSGKVITSGILINILNPKLSIFFFAFLPQFVSTTEPHAFAKMLELSGVFMLMTFLVFAGYGVFAAAVRSHVVSRPKVLTWMRRTFAGAFVMLGAKLALTDR
>CP034451.1|AZO08529.1|1049447_1049807_-|YkgJ-family-cysteine-cluster-protein
MRIALPHDHFAAFDCRSCGACCAYAADWPRFSTEEDAELERIPEKLVAADQSGMRCEGGRCAALRGDVGKQVACTVYEARPHVCRACMPGGGDCLMARAAYGLPLVAPPVPRSIGLSLD
>CP034451.1|AZO08530.1|1050004_1050784_-|ATPase
MASNDRPRAIADVSAGTILATVTIAVPPERVFRAITADDQIPLWWGADDMYRTTKHTADLRPGGAWRSEGKSADGQDFHVGGEYLEVEPPHRLVMTWKAPWDGDNVTTVTYTLEAVEEGTRLTLRHDGFGPRQESCRSHGSGWERVLGWLGGFLAAEAGRNAPAVFHCRLIPPRPDFAFTMTEEERALMGDHADYLRSQLRHGTMMIAGPVADPAGPWGLCILRVATEAEARAVTDGDPVLRSGRGFRYEVLPMMSVIM
>CP034451.1|AZO08531.1|1050783_1051119_-|ArsR-family-transcriptional-regulator
MPQADPDRSVFRAIADPTRRAILDRLRKGPAPVNELASAFSQSRPAISKHLRILRELNVVSEQRQGRERVYRLEPAELKDVADWILPYRDFWQQSLGNLKSYLERADLEDD
>CP034451.1|AZO08532.1|1051286_1051946_-|glutathione-S-transferase-family-protein
MAEFTLYIGNKCFSSWSLRPWVAMRHLEIPFQESFVRLRTPETAANLAKVSPTGLVPVLDHNGRIVWETLAILEYLADLFPQKRLWPEELGARALARSVATEMHSGFREVRYGWPMNLRRPKSHKPLDAEGEVQRARIETIWRECRDQYGKDGPFLFGHFTAADAMYAPIVTRFDTYGGELAPVTRAYVDAVLATPAMRHWYAEAAKEPWPEPGPHEQD
>CP034451.1|AZO08533.1|1052087_1052267_+|CsbD-family-protein
MVNIDQVAGLAKQIRGSIRQAVGRATGNRRMQIKGMADTATGKVQKACGDMKAMCKKAM
>CP034451.1|AZO08534.1|1052284_1053433_-|metallophosphoesterase
MFNRATMNRRSPATVSRRAFLSQMGSLAALCAAPRAALGQAGRAIQPIDATFLFIADIHACRMASGLSPNCLQEGKTDAALLRNVAALNALADKQWPAEINGVATGLHSAGARIGTPLGLVTGGDITDDGGGQVTEPSEGTQLLQFSQRYQQGIGPDRVHMPVYVGLGNHDLDQNGSPPHIDWYRRELRDYVEVNHRPGVFFKPPVPATNYDIDTDCYSWDWGGLHLVQTHRFAGDTGHGAPSGLPWLKQDLATYAADGRPVILFQHYGWDTFSIERWDPAKRTFSDEGSGAPHWWSDGDRHALLGVLKGYNVVAVFHGHQHEVPMIYQRDGLNLVKPKAAYLGGFALARVTNDNLDVVLGEATGDHGEIVFTNAFAKALET
>CP034451.1|AZO08535.1|1053496_1053826_-|hypothetical-protein
MRFLVVSFVAVAIPYGFERVFFGRKFGFFAALFWLFVIQLALLFGGEVILESQVGQSLPSWLKSISFAVGALAHLTIGMTPLAAVIAALAFGTVIAATRVLRKLRETPD
>CP034451.1|AZO08536.1|1054066_1054660_+|hypothetical-protein
MKTITIGMTLAMLSLAGAAQAADCVDAKSAKAGFVLEKPGIRSEFRPAPGGMVAVANNYQSQSPQTQYLYAGLIEVFRDSDTGRLSMIPLGDIKKLFPLKAGAKSKTQFVRLSTKKTPKGTETLALAVKGKESYKLGDCKYTVLAVSETITGDSGAVIDTFTALYSPDLQAVLARRYDEGTSAQSQVGFETIKPLKE
>CP034451.1|AZO12888.1|1054746_1055574_-|alpha/beta-hydrolase
MDLEEQEAEQGAWAARKQIADAGGLDLAYVEVAGSEPPLLLIHGFTDTSRSFSLLASHLSGRRLVIPDLRGHGASQAGDGCGVADFAEDIAGLIRDLRLDRPIVVGHSLGAMVSIALAAHHSELVGRLVVMAGTLKPDFAPDHALVAGVAALRDPISSADPFYDWWHACRPGVPTAFLSRLADDASAMPAARWRAILEEIRRTDLTMAARAVRAPTLIIAGACDPLFSETHQQALAVALAGSRLIWAQDCGHNPHWEDPALIASAIAGALQNAEA

Crispr_ID: CP034451_2

• CRISPR_ID: CP034451_2
• CRISPR_location: 1232634-1232723
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP034451_2

Consensus_repeat	Method
CATCGCGGTCCGCGCGGGAATGC	CRISPRCasFinder

spacers of CP034451_2

>2.1|1232657|44|CP034451|CRISPRCasFinder
GGTCCGCGCGGGAATGCGTGACGACAGAAGGGCGGACCGCGAGA

CRISPR arrays and Neighbor proteins around CP034451_2

CRISPR arrays

The CRISPR arrays of CP034451_2

>merge|CP034451|2|1232634-1232723|CRISPRCasFinder
CCGCGCGGACCGCGAGGCATCGCGGTCCGCGCGGGAATGCGTGACGACAGAAGGGCGGACCGCGAGACATCGCGGTCCGCGCGGGCATGC

>CP034451|2|2|1232634-1232723|CRISPRCasFinder
CCGCGCGGACCGCGAGGCATCGC	GGTCCGCGCGGGAATGCGTGACGACAGAAGGGCGGACCGCGAGA
CATCGCGGTCCGCGCGGGCATGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP034451.1|AZO12909.1|1243419_1244016_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08697.1|1228181_1229078_+|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|176149
CP034451.1|AZO12907.1|1224688_1225402_-|alpha/beta-fold-hydrolase	unknown	unknown	gnl|CDD|131480
CP034451.1|AZO08705.1|1239169_1239484_+|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08700.1|1231039_1231972_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08709.1|1244259_1244565_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08693.1|1222235_1222544_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08696.1|1226609_1228118_-|MFS-transporter	unknown	unknown	gnl|CDD|129794
CP034451.1|AZO12908.1|1241633_1242695_-|ISAs1-family-transposase	unknown	unknown	gnl|CDD|379382
CP034451.1|AZO08708.1|1242966_1243272_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08702.1|1232906_1233449_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08694.1|1222854_1222950_+|putative-RiPP-precursor	unknown	unknown	unknown
CP034451.1|AZO08706.1|1239718_1240078_+|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08698.1|1229335_1229629_+|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08703.1|1233750_1235763_+|acyltransferase	unknown	unknown	gnl|CDD|224748
CP034451.1|AZO08707.1|1240182_1241460_+|DUF763-domain-containing-protein	unknown	unknown	gnl|CDD|377525
CP034451.1|AZO08695.1|1224449_1224665_+|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08701.1|1232145_1232376_+|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO08699.1|1230645_1230735_-|putative-RiPP-precursor	unknown	unknown	unknown
CP034451.1|AZO08704.1|1235986_1236340_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|225981

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP034451.1|AZO08697.1|1228181_1229078_+|LysR-family-transcriptional-regulator	gnl|CDD|176149	cd08460, PBP2_DntR_like_1, The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold. This CD includes an uncharacterized LysR-type transcriptional regulator similar to DntR, NahR, and LinR, which are involved in the degradation of aromatic compounds. The transcription of the genes encoding enzymes involved in such degradation is regulated and expression of these enzymes is enhanced by inducers, which are either an intermediate in the metabolic pathway or compounds to be degraded. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	2.4547e-89
CP034451.1|AZO12908.1|1241633_1242695_-|ISAs1-family-transposase	gnl|CDD|379382	pfam13808, DDE_Tnp_1_assoc, DDE_Tnp_1-associated. This domain is frequently found N-terminal to the transposase, IS family DDE_Tnp_1, pfam01609 and its relatives.	9.59649e-21
CP034451.1|AZO12907.1|1224688_1225402_-|alpha/beta-fold-hydrolase	gnl|CDD|131480	TIGR02427, b-ketoadipate_enol-lactone_hydrolase, 3-oxoadipate enol-lactonase. Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other].	4.57032e-22
CP034451.1|AZO08707.1|1240182_1241460_+|DUF763-domain-containing-protein	gnl|CDD|377525	pfam05559, DUF763, Protein of unknown function (DUF763). This family consists of several uncharacterized bacterial and archaeal proteins of unknown function.	0
CP034451.1|AZO08703.1|1233750_1235763_+|acyltransferase	gnl|CDD|224748	COG1835, COG1835, Predicted acyltransferases [Lipid metabolism].	1.27373e-70
CP034451.1|AZO08696.1|1226609_1228118_-|MFS-transporter	gnl|CDD|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.15191e-37
CP034451.1|AZO08704.1|1235986_1236340_-|cupin-domain-containing-protein	gnl|CDD|225981	COG3450, COG3450, Predicted enzyme of the cupin superfamily [General function prediction only].	7.03151e-40

Protein sequences

>CP034451.1|AZO08701.1|1232145_1232376_+|hypothetical-protein
MKIVLSVLVVALALSQAAIAKEKIPPHGTKVVKTQKTPPLDQTVTGGTIAPAGSTASSADQSQLGQGYPEALDLHF
>CP034451.1|AZO08700.1|1231039_1231972_-|hypothetical-protein
MAQHIAQKLRLTSAVLGTVSRKDLAAAFRAVNPKTAFDLGRADKWLQGRAHPRELSVYDDWAKVLRLDQPGAWIAESDLSSFTAEISARHGIDSADLERRAVAQVEASSAHDDRGLSIALVGSYACYSRAWSPYYRGQLIKGSLAIEAGPGVHGLTATYREALPTGQLALAGPVTPAKRGLYLHLKETGGDAQFFFSLFPQSQPGSVLGGYMCGTAIIGPEAQPSLTRILIIRLRHAAPDASWGGYLLPGGSIAADLAGLGIAIEHPETVDRQLGQFLAVDGDGGANQIPPAEFRAILDVFDRHWLRQPA
>CP034451.1|AZO08699.1|1230645_1230735_-|putative-RiPP-precursor
MKKVYAKPTLEKRGKLSAVTAANGSSILI
>CP034451.1|AZO08698.1|1229335_1229629_+|hypothetical-protein
MKTRFLFLGAMALSIMAGSAMAGSTTGTSALDDPQKMSPFFTDAGMKTMKSEADFKTAWMALTEEDRTSMKKDCGDEAIAKQHDDFCKMTKQLGGAN
>CP034451.1|AZO08697.1|1228181_1229078_+|LysR-family-transcriptional-regulator
MSRPDLNLLFTLDVLLAEGSVAKAARRLRLSPSAMSRALARLREATGDPLLVRAGRGLVPTSRAIELSAEVGQLVKQAEAMLRPAAKLDLKRLVRSFTLRNSDGFVENFGPGLIARVAAEAPGVQLRFVAKPDKDSAPMREGGVDLETGVVGGSTGPEVRAQALFRDRFVGVVRQGHPLSQARVTAARFAAGRHILISRRGLDRGPVDEALELDGLRREIATVVGGFSEALALARGSDLIATVPERYTGKLREGMFSFALPLRLAELTISLLWHPRLDADPAHRWLRALVREVCAGRS
>CP034451.1|AZO08696.1|1226609_1228118_-|MFS-transporter
MLHVPPYLAAAYLAGKSHPRRRSTMADIAHSHVASASRSTAGALASLSLAMLLSSLSTSIANVALPTLSTAFAASFPAVQWVVLAYLVAITAFIVSVGRLGDLVGRRLLLVAGLGLFSAASLAAALAPSLALLVAARAAQGLGAAVMMALTVAFVGETVPRERTGSAMGLLGTMSAIGTALGPSLGGVLIAALGWRAIFLVNAGLGLVALLAAQRFLPAAREAKAASAVGQPAKKTGPRFDVLGTLLLAATLAAYALAMTIGRGHFGGLNMALLAVAALGAGLFVIAEGRVAAPLVNLSLLRGSVLGSSLAVNALVSTVMMATLVVVPFYLSRALGLGEALTGAVMSIGPVVSALCGVVSGRIVDRLGAGRMIIAGLAMMVVGCLALSMLPGLFGLAGYTAAIVLLTPGYQLFQAANNTAVMLDVGERERGVVSAMLSLSRNLGLVTGAAAMGAVFAFAVGARDIGRAAPEAVASGMRVTFAVAAGLVVVALLIAVGRWRKR
>CP034451.1|AZO12907.1|1224688_1225402_-|alpha/beta-fold-hydrolase
MWRHWIAALSRDNQLVRYDERCNGLSQRQVPDVSFDTMVSDLECVVEAAGLDRFTLLGLSQSCAVSIAYAIRHPEKVSGMILYGGYVKGWRARGDAGEIATREAIATLMREGWGKSNPMFRQVFCSMFIPGATHEHFAWMDELLLRTILPDDAWRLQSAFSVIDVGDLLEKVSVPTLVLHARDDNVAPVESGRTLAAGIPGARFLELESRNHILLEGEPAFDEFVGHVRAFIAETAG
>CP034451.1|AZO08695.1|1224449_1224665_+|hypothetical-protein
MRFAVIQDPCDDWMVYDLLYDLPAEIAGELPVGLTREEAERLARQANQGRPVRLRALPGDGGTAIHQIRRL
>CP034451.1|AZO08694.1|1222854_1222950_+|putative-RiPP-precursor
MKKTYEKPTLTRREKLGAVTAVPAASGPTTI
>CP034451.1|AZO08693.1|1222235_1222544_-|hypothetical-protein
MKTVLLAALALSIAAPAVASPAEADLVIKTHHRHHHRHAVVINDEGQRLHHRRHGTEAFYDNGRRAWHRHHRRDTVVITGSIERHHYRHHRRHVIVDSDTDY
>CP034451.1|AZO08702.1|1232906_1233449_-|hypothetical-protein
MKRLLTVAALMAAGSLIAMQSAVADDAALIKSAESAAPAAVASGAAIYSMDDKGNMKTLREGKNGFWCMPDNPASPGPDPMCGDANSMEWAMAWLEKKDPPKGKVGFMYMLSGGTDGSNTDPYATAPAEGNNWIETGPHVMIVNAMDMMAGYPTDPKPDTSKPYVMWPGTPYAHLMIPVK
>CP034451.1|AZO08703.1|1233750_1235763_+|acyltransferase
MSEPSQGFRPDIEGLRALAVAGVVAFHFGLTGLPGGFAGVDIFFVISGYLITRHLVAEMSSTGRLDLLRFYARRARRLLPAALFVILATLAFGVIVLSPEEQALYSKGAMFASAYMINLWLIRWSFDYFANDAASNPFIHYWSLSVEEQFYLAWPALLMLAAWLKPGRRAIVLAIGIAGLVSFAVCAWLTTVSQPWAFYFSPLRAWEFAAGGLASLAPAWLLAKRPRLGLGFGLAGLAMIAFAYLTFSEDSPFPGFLALVPVAGTVLLLLAGAAGVGNGISSRNSERKTAGHFSWNCVNAFLALPPLQWVGRLSYSLYLWHWPVIVYAGMLTTELSVPQRLICLGLTLALSVLTYHLIENPIRRNGWLMANAARALVPALLLTGTGVAAAYGNARLAVHDLDPEQREIAASAAEPATARASACVQDYFTVRPAPCVFGTGRRAIALFGDSHADHWSTPLIEAARKDGYRVETWLKSSCRASRFTFFVAKLKRNYSECDQWREQAIKEIIQAKPALVVISELALTSSRKMAEGKREPDTSDAAWQAGLRSTLTTLSNAGLKIAFIRDVPFNDEHIDTCVARALWRGGTPSLCDQARADAANDKMAAVEREIVTSVPNASYVDLTDRFCNATTCHVFIDGKLAFRDQHHLATPFAESLEPEVEKRVISKVGR
>CP034451.1|AZO08704.1|1235986_1236340_-|cupin-domain-containing-protein
MTKQTILKFGAVEHADPGDLPGWVVVEGRPTMQTAVQHTSEDGKVMSGTWRASPGTYHATYTDYEFVHMIAGRIIITPDGGESVEVGPGDAFVVEADFKGTWKIVEPVTKHFVVVVG
>CP034451.1|AZO08705.1|1239169_1239484_+|hypothetical-protein
MKRLLLASMIAIASAFAVAPASAGGVQLGIGIGPSYDPYYGDYYGGYYPHRYYRHVYDDDYYTPYRDRYVVRYHHRHYRNCRIKLVKHWRHHHRVVEEVRICRR
>CP034451.1|AZO08706.1|1239718_1240078_+|hypothetical-protein
MKKLLLASVIAVASAAATIAPADAQGFFGLGLSPFGGPFGGPFGGPFPFYRPYYGGPFYDYGGRYYGPRYYNDYYPGYAVRYPHRYYYRHRHYRHCHVKWVRHWHHHRRVLERVRVCRY
>CP034451.1|AZO08707.1|1240182_1241460_+|DUF763-domain-containing-protein
MTQRSGSADLPLHGGRVPKWLGERMTKLGAVLCEAIIHHYGRDELSRRLAHPFWFQSFGAVMGMDWHSSGITTSVIGALKRGLNPMAGELGIHVCGGRGAHSRKTPGELLAIGDHVGLDGAALATASRLVAKVDSAAVQDGFDLYLHGFIVTDDGRWVVVQQGMNGDARQARRYHWLSEGLTSFVDQPHAAIEGERQGEIVNLTDHRAEKARSGQIALLKTMSPEKILAELAVLEPQPERAKPEIGLAAQPLLPHLVMPAHHDVRESDIVMRRLHGNISAAIDSGPKDFPELLLVPGVGPRTVRALAMVSEVVHGAPCRFSDPARFSLAHGGKDRHPFPVPLKVYDETISVLKSAVSKARLGREEELQALKRLDGESRRMERYVTGPSLKEIVAGEMDQSHLLGGRSVFGWEGAPEGGPKPLKDA
>CP034451.1|AZO12908.1|1241633_1242695_-|ISAs1-family-transposase
MSSLESYFGALPDPRAGNATHRLGDLIVMMIAASLCGASNATEFSLFAQERKQALSRLIEYEVAPSHDTFSRLLRLLDPEAFGRAFAAFAAGFARACEEVVSLDGKALRRAYEKGLAASPPLTVSAFAAETRLCLAAVSPGAGENEVEAALRVVELIDLTGRMVTADALHCHTRMAKAITERGGDYLLALKGNRRHWVAHAKQQLTEITPAVAERTETSHGRSEWRQAEVVAAAEPLMPGHKAFIRITSRRDQTKPLTRLFMASTLLSPQQALELTRAHWQIENGLHWMLDVHLDEDQSRARKDNAPANTALLNRIARNILQGADVDKVPISHRIKKCAWNDDYLIQALTHMR
>CP034451.1|AZO08708.1|1242966_1243272_-|hypothetical-protein
MTKLWELEKTVEVEFTVETAIYRFRLEAQKPAHEHGRYRIRLFEYDLFRIKPTLGDYPEGGADHEIQFAANLSIDRKEYKAASADEALQMAIDDLRKQLFV
>CP034451.1|AZO12909.1|1243419_1244016_-|hypothetical-protein
MPRKSARKPAPPKLPKGEAEQVRIRREVGHDFALKTDAHGRQRLTPGTAEARRVYEVSNGGYTSTGGIVRLRNVDPLTGITSLTRQQREAGQRFRDDFERTAREGLQPQSWSERVDGGRVGGGIPDRVLSAGRAHAHAEAALAHWEVAEVVRKICLEGQSVKAIAERSGEGRDVVVKLLKVGLDLLAVHYGMMGRRAG
>CP034451.1|AZO08709.1|1244259_1244565_-|hypothetical-protein
MTAAELQQAAKALAAMFSCFPQSALADADMQLRGYLAAVQDAEFCDVQAAIQRFIRGEAKVVNAQFCPSSAQLSIEVRERRLMRELLAKRKGQSPVRLVKA

Crispr_ID: CP034451_3

• CRISPR_ID: CP034451_3
• CRISPR_location: 1743053-1743151
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP034451_3

Consensus_repeat	Method
AATCCCAAAACCGCTGCGCACTTTTGGGCGACATGCA	CRISPRCasFinder

spacers of CP034451_3

>3.1|1743090|25|CP034451|CRISPRCasFinder
TCGACTTTGTTCTGGTGCATGCCGC

CRISPR arrays and Neighbor proteins around CP034451_3

CRISPR arrays

The CRISPR arrays of CP034451_3

>merge|CP034451|3|1743053-1743151|CRISPRCasFinder
AATCCCAAAACCGCTGCGCACTTTTGGGCGACATGCATCGACTTTGTTCTGGTGCATGCCGCAATCCCAAAACCGCTGCGCATTTTTGGGCGACATGCA

>CP034451|3|3|1743053-1743151|CRISPRCasFinder
AATCCCAAAACCGCTGCGCACTTTTGGGCGACATGCA	TCGACTTTGTTCTGGTGCATGCCGC
AATCCCAAAACCGCTGCGCATTTTTGGGCGACATGCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP034451.1|AZO09152.1|1726596_1728213_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|226641
CP034451.1|AZO09156.1|1732425_1734069_-|DUF3459-domain-containing-protein	unknown	unknown	gnl|CDD|200469
CP034451.1|AZO09165.1|1747801_1748836_-|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|380628
CP034451.1|AZO09160.1|1739469_1740735_-|glucose-1-phosphate-adenylyltransferase	unknown	unknown	gnl|CDD|234824
CP034451.1|AZO09157.1|1734068_1736069_-|glycogen-debranching-enzyme-GlgX	unknown	unknown	gnl|CDD|131155
CP034451.1|AZO09155.1|1730444_1732037_-|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|173869
CP034451.1|AZO12944.1|1751893_1753036_+|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein	unknown	unknown	gnl|CDD|223476
CP034451.1|AZO09153.1|1728230_1729355_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|185304
CP034451.1|AZO09164.1|1746575_1747640_-|ABC-transporter-permease	unknown	unknown	gnl|CDD|224093
CP034451.1|AZO09167.1|1750273_1750720_+|transporter	unknown	unknown	gnl|CDD|226632
CP034451.1|AZO09163.1|1745790_1746573_-|sugar-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224053
CP034451.1|AZO09158.1|1736265_1737894_-|alpha-D-glucose-phosphate-specific-phosphoglucomutase	unknown	unknown	gnl|CDD|100087
CP034451.1|AZO09166.1|1749045_1750272_+|ROK-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224851
CP034451.1|AZO09162.1|1743189_1745652_-|glycogen/starch/alpha-glucan-phosphorylase	unknown	unknown	gnl|CDD|273967
CP034451.1|AZO09168.1|1750716_1751640_+|carbohydrate-kinase	unknown	unknown	gnl|CDD|238572
CP034451.1|AZO09159.1|1737896_1739342_-|glycogen-synthase-GlgA	unknown	unknown	gnl|CDD|234809
CP034451.1|AZO12945.1|1753156_1754002_-|3'(2'),5'-bisphosphate-nucleotidase	unknown	unknown	gnl|CDD|130398
CP034451.1|AZO09169.1|1753964_1755908_-|sulfate-adenylyltransferase-subunit-CysN	unknown	unknown	gnl|CDD|180120
CP034451.1|AZO09161.1|1740796_1743007_-|1,4-alpha-glucan-branching-protein-GlgB	unknown	unknown	gnl|CDD|235445
CP034451.1|AZO09154.1|1729347_1730271_-|ABC-transporter-permease-subunit	unknown	unknown	gnl|CDD|181886

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP034451.1|AZO09152.1|1726596_1728213_-|ABC-transporter-ATP-binding-protein	gnl|CDD|226641	COG4172, COG4172, ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only].	0
CP034451.1|AZO09156.1|1732425_1734069_-|DUF3459-domain-containing-protein	gnl|CDD|200469	cd11330, AmyAc_OligoGlu, Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins. Oligo-1,6-glucosidase (EC 3.2.1.10) hydrolyzes the alpha-1,6-glucosidic linkage of isomalto-oligosaccharides, pannose, and dextran. Unlike alpha-1,4-glucosidases (EC 3.2.1.20), it fails to hydrolyze the alpha-1,4-glucosidic bonds of maltosaccharides. The Alpha-amylase family comprises the largest family of glycoside hydrolases (GH), with the majority of enzymes acting on starch, glycogen, and related oligo- and polysaccharides. These proteins catalyze the transformation of alpha-1,4 and alpha-1,6 glucosidic linkages with retention of the anomeric center. The protein is described as having 3 domains: A, B, C. A is a (beta/alpha) 8-barrel; B is a loop between the beta 3 strand and alpha 3 helix of A; C is the C-terminal extension characterized by a Greek key. The majority of the enzymes have an active site cleft found between domains A and B where a triad of catalytic residues (Asp, Glu and Asp) performs catalysis. Other members of this family have lost the catalytic activity as in the case of the human 4F2hc, or only have 2 residues that serve as the catalytic nucleophile and the acid/base, such as Thermus A4 beta-galactosidase with 2 Glu residues (GH42) and human alpha-galactosidase with 2 Asp residues (GH31). The family members are quite extensive and include: alpha amylase, maltosyltransferase, cyclodextrin glycotransferase, maltogenic amylase, neopullulanase, isoamylase, 1,4-alpha-D-glucan maltotetrahydrolase, 4-alpha-glucotransferase, oligo-1,6-glucosidase, amylosucrase, sucrose phosphorylase, and amylomaltase.	0
CP034451.1|AZO09165.1|1747801_1748836_-|sugar-ABC-transporter-substrate-binding-protein	gnl|CDD|380628	cd19973, PBP1_ABC_sugar_binding-like, monosaccharide ABC transporter substrate-binding protein. Periplasmic sugar-binding domain of active transport systems that are members of the type 1 periplasmic binding protein (PBP1) superfamily. The members of this family function as the primary receptors for chemotaxis and transport of many sugar based solutes in bacteria and archaea. The sugar binding domain is also homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR. Moreover, this periplasmic binding domain, also known as Venus flytrap domain, undergoes transition from an open to a closed conformational state upon the binding of ligands such as lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. This family also includes the periplasmic binding domain of autoinducer-2 (AI-2) receptors such as LsrB and LuxP which are highly homologous to periplasmic pentose/hexose sugar-binding proteins.	1.39027e-158
CP034451.1|AZO09160.1|1739469_1740735_-|glucose-1-phosphate-adenylyltransferase	gnl|CDD|234824	PRK00725, glgC, glucose-1-phosphate adenylyltransferase; Provisional.	0
CP034451.1|AZO09157.1|1734068_1736069_-|glycogen-debranching-enzyme-GlgX	gnl|CDD|131155	TIGR02100, Glycogen_operon_protein_GlgX_homolog, glycogen debranching enzyme GlgX. This family consists of the GlgX protein from the E. coli glycogen operon and probable equivalogs from other prokaryotic species. GlgX is not required for glycogen biosynthesis, but instead acts as a debranching enzyme for glycogen catabolism. This model distinguishes GlgX from pullanases and other related proteins that also operate on alpha-1,6-glycosidic linkages. In the wide band between the trusted and noise cutoffs are functionally similar enzymes, mostly from plants, that act similarly but usually are termed isoamylase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
CP034451.1|AZO09155.1|1730444_1732037_-|peptide-ABC-transporter-substrate-binding-protein	gnl|CDD|173869	cd08504, PBP2_OppA, The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding component of an ATP-binding cassette (ABC)-type oligopeptide transport system comprised of 5 subunits. The transport system OppABCDEF contains two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
CP034451.1|AZO12944.1|1751893_1753036_+|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein	gnl|CDD|223476	COG0399, WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane].	1.0861e-148
CP034451.1|AZO09153.1|1728230_1729355_-|ABC-transporter-permease-subunit	gnl|CDD|185304	PRK15406, PRK15406, oligopeptide ABC transporter permease OppC; Provisional.	4.29504e-101
CP034451.1|AZO09164.1|1746575_1747640_-|ABC-transporter-permease	gnl|CDD|224093	COG1172, AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism].	5.16617e-80
CP034451.1|AZO09167.1|1750273_1750720_+|transporter	gnl|CDD|226632	COG4154, FucU, Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism].	1.56566e-60
CP034451.1|AZO09163.1|1745790_1746573_-|sugar-ABC-transporter-ATP-binding-protein	gnl|CDD|224053	COG1129, MglA, ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism].	4.47293e-110
CP034451.1|AZO09158.1|1736265_1737894_-|alpha-D-glucose-phosphate-specific-phosphoglucomutase	gnl|CDD|100087	cd03085, PGM1, Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction, G-1-P produced from sucrose catabolism is converted to G-6-P, the first intermediate in glycolysis. In the other direction, conversion of G-6-P to G-1-P generates a substrate for synthesis of UDP-glucose which is required for synthesis of a variety of cellular constituents including cell wall polymers and glycoproteins. The PGM1 family also includes a non-enzymatic PGM-related protein (PGM-RP) thought to play a structural role in eukaryotes, as well as pp63/parafusin, a phosphoglycoprotein that plays an important role in calcium-regulated exocytosis in ciliated protozoans. PGM1 belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.	0
CP034451.1|AZO09166.1|1749045_1750272_+|ROK-family-transcriptional-regulator	gnl|CDD|224851	COG1940, NagC, Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism].	2.34323e-47
CP034451.1|AZO09162.1|1743189_1745652_-|glycogen/starch/alpha-glucan-phosphorylase	gnl|CDD|273967	TIGR02093, Glycogen_phosphorylase, glycogen/starch/alpha-glucan phosphorylases. This family consists of phosphorylases. Members use phosphate to break alpha 1,4 linkages between pairs of glucose residues at the end of long glucose polymers, releasing alpha-D-glucose 1-phosphate. The nomenclature convention is to preface the name according to the natural substrate, as in glycogen phosphorylase, starch phosphorylase, maltodextrin phosphorylase, etc. Name differences among these substrates reflect differences in patterns of branching with alpha 1,6 linkages. Members include allosterically regulated and unregulated forms. A related family, TIGR02094, contains examples known to act well on particularly small alpha 1,4 glucans, as may be found after import from exogenous sources. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
CP034451.1|AZO09168.1|1750716_1751640_+|carbohydrate-kinase	gnl|CDD|238572	cd01167, bac_FRK, Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate. This is in contrast to FRKs [or ketohexokinases (KHKs)] from mammalia and halophilic archaebacteria, which phosphorylate fructose to fructose-1-phosphate.	2.13315e-92
CP034451.1|AZO09159.1|1737896_1739342_-|glycogen-synthase-GlgA	gnl|CDD|234809	PRK00654, glgA, glycogen synthase GlgA.	0
CP034451.1|AZO12945.1|1753156_1754002_-|3'(2'),5'-bisphosphate-nucleotidase	gnl|CDD|130398	TIGR01331, 3'2'5'-bisphosphate_nucleotidase_CysQ, 3'(2'),5'-bisphosphate nucleotidase, bacterial. Sulfate is incorporated into 3-phosphoadenylylsulfate, PAPS, for utilization in pathways such as methionine biosynthesis. Transfer of sulfate from PAPS to an acceptor leaves adenosine 3'-5'-bisphosphate, APS. This model describes a form found in bacteria of the enzyme 3'(2'),5'-bisphosphate nucleotidase, which removes the 3'-phosphate from APS to regenerate AMP and help drive the cycle. [Central intermediary metabolism, Sulfur metabolism].	1.81757e-117
CP034451.1|AZO09169.1|1753964_1755908_-|sulfate-adenylyltransferase-subunit-CysN	gnl|CDD|180120	PRK05506, PRK05506, bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional.	0
CP034451.1|AZO09161.1|1740796_1743007_-|1,4-alpha-glucan-branching-protein-GlgB	gnl|CDD|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
CP034451.1|AZO09154.1|1729347_1730271_-|ABC-transporter-permease-subunit	gnl|CDD|181886	PRK09471, oppB, oligopeptide ABC transporter permease OppB.	3.3069e-126

Protein sequences

>CP034451.1|AZO09161.1|1740796_1743007_-|1,4-alpha-glucan-branching-protein-GlgB
MRKPRATAATSGPDGLAPAGDVAAIVAGTHGDPFAILGVHEAGKGFVARCFVPNAESVTAYTLAGKEAGELVRSNDAGFFEGRLSIRKRQPLRYHAKNAGADWWLTDPYSFGPVLGPMDDYYMAEGSHLRLFDKLGAHIIDHEGATGVHFAVWAPNAKRVSVVGDFNEWDGRRHTMRDRKDTGIWELFIPDLGAGRPYKFEIIAPDGVRLPLKADPFAFESELRPATASVTAPPMAHRWGDEAHRSFWQKADPRREAISIYEVHAGSWQLRDDGTFLSWDELAERLIPYVVDTGFTHIEFLPISEHPFDPSWGYQTTGLYTPTARFGDPDGFARFVDGAHRAGVGVILDWVPAHFPVDEHGLVRFDGTALYEHEDPRQGFHPDWNTAIYNFGRREVVSFLVNNALFWAEKYHVDGLRVDAVASMLYLDYSRKAGEWIPNEKGGRENLQAVDFLQKMNKELYGHHPGVITIAEESTSWPKVSRPVHEGGLGFGFKWNMGFMHDTLEYLSKEPIYRKHHHNEVTFGLIYAFSENFVLPLSHDEVVHGKGTLLHKMAGDDWQKFATLRAYYAFMWGYPGKKLLFMGQEFAQRREWSEARALDWDLLQHGPHRGVRQVVRDLNYLYRSRPALHARDCEPEGFSWLIVDDRDNSVFAWLRSAPGGNPIAVISNFTPVPRENYRVPLPKAGEWREIINTDAGDYGGSGMGNGGMVEASGEEGTSATMLLPPLSTIMLEFVAD
>CP034451.1|AZO09160.1|1739469_1740735_-|glucose-1-phosphate-adenylyltransferase
MADTKRTQPLARDAMAYVLAGGRGSRLKELTDRRAKPAVYFGGKTRIIDFALSNALNSGIRRLGVATQYKAHSLIRHLQRGWNFLRPERNESFDILPASQRVSETQWYEGTADAVYQNIDIIEAYNPEYMVILAGDHIYKMDYELMLRQHVDANADVTVGCLEVPRMEATGFGVMHVDAKDNIISFIEKPADPPGIPDKPDFALASMGIYVFRTKFLMDQLRRDAAEPGSSRDFGKDIIPHVVQHGKAVAHRFAKSCVRSTAENEAYWRDVGTVDAYWEANIDLTDVTPELDLYDRDWPIWTYAELKPPAKFVHDEDGRRGEAISSLVSGDCIISGASLRRSLIFTGARINSYSKLEEVVMLPDCYVGRNAHLKRVVIDHGVRIPEGLVVGEDPVLDAKRFRVSEKGICLITQDMINKLSS
>CP034451.1|AZO09159.1|1737896_1739342_-|glycogen-synthase-GlgA
MQVLSVTPEIFPLIKTGGLADVTGALPIALAGKGVAMRTLVPGYPVVMDAFKKKKALYQYPLLQGGKASVHAVRIGELDLFVLDAPHLFDRQGGPYGTVSGSDWPDNWRRFAALSQVGGDIAGGAISGYQPDLVHAHDWQSAMTLAYMRYGKAVGVPSLITVHNLAFQGQFGAGIFGELGLPGPAMQLDGVEYYGGVGYLKAGLQAAWAITTVSPTYAQEIRSPEFGMGLDGLINMRAVDLYGIVNGIDVDIWNPETDKHLVANYSAEKLDARRPNRKAVEDRFNLESDDSPIVCVISRLTWQKGMDILAAVVDGIVQRGARLAVLGSGDAGLEGSLLAAAARHRGRIGVVIGYDEALSHVMQGGCDAIVIPSRFEPCGLTQLYGLRYGCVPIVARTGGLADTIIDANQAALSAGVATGFQFAPNNGGALLHAIRQLVEVHARPAAWASIQRQGMKADVSWDRSAEKYVELYRLLLSKRVA
>CP034451.1|AZO09158.1|1736265_1737894_-|alpha-D-glucose-phosphate-specific-phosphoglucomutase
MIRTVPTKPYPDQKPGTSGLRKKVPVFQQEHYAENFIQSIFDALEGFEGKTLVIGGDGRYYNREVIQKAIAMAAANGFGKVMVGQGGILSTPAASNIIRKYKTFGGIILSASHNPGGPHEDFGIKYNAGNGGPAPEKITDAIFAKTKTISSFKIADIGEIDIDTVGTVRAGDMTVEIIDPVTDYAELMESLFDFDAIRANFKYGFRMRFDAMHAVTGPYAKEILERRLGAPNGTCRNFKPLPDFGGHHPDPNLVHAKHLYDEMMGSDAPDFGAASDGDGDRNLIIGKGIFVTPSDSLAMLAANAHLAPGYKEGLKGIARSMPTSGAADRVAEKLGVGMYETPTGWKFFGNLLDAGMATICGEESAGTGSNHVREKDGLWAVLLWLNILAVRGESCKDIVTKHWETYGRNYYSRHDYEEVETDRANALVDELRAKLSSLPGTSVRGMKIASADDFAYHDPVDGSVSKNQGIRILFEGGSRVVFRLSGTGTSGATLRVYIERYEPDKSRHGLDTQEALADLIAAADDIAGIKSHTGRNKPSVIT
>CP034451.1|AZO09157.1|1734068_1736069_-|glycogen-debranching-enzyme-GlgX
MTNLGATITPEGTRFAVWSSSARRLWVSIFDDAGAREIERLELKPEGEGLHALFVSGLAEGTRYGLRADGDYAPERGLWFDPDKLLADPYAAEIDRSYQYHWRLAAKRNEGADTAPLMPKTVACAPPQPLLAGPPLFQPGGLIYELNVRSFTKLHPDVPQAQRGTIAALAHPAVIEHLKRLGVSAVELMPITASIDERHLPPLGLSNAWGYNPVTFMAIDPRLAPGGLQELRDTVAALGEAGVGTILDLVLNHTGESDRLGPTLSLRGLDAEAYFRHQPDGRLVNDTGTGNTVACDHPAVQQMVLDTLRHFVRHAGVDGFRFDLAPVLGRVDGAFDPSAPLLQAIAGDPVLADRVLIAEPWDIGPNGYQLGNFRPPYLEWNDRCRDDVRRFWRGDSGAVGALATRLAGSSDVFGKDGQPVSRSVNFIAAHDGMTLADIVAYERKHNAANGEQNRDGHNDNLSWNNGVEGETDDTAVAKARFNDQCALLATLFASRGTIMLTAGDEFGRSQKGNNNAYAQDNAVTWVDWAGRDQALEQYTAALSALRRAFPVLSDTRFLTGKPADGSDIPDVVWLTETGAPLGDGDWHDPARHRLVMLLGDSGGGRLAVIINGDRRQCLFTLPVRDGFEWRPAIEAQPVDIARPLAGRSVSLMIEQRAEKARARKGS
>CP034451.1|AZO09156.1|1732425_1734069_-|DUF3459-domain-containing-protein
MAAGNAEREAEWWRGCVIYQIYPRSFQDSTGDGSGDLKGITARLAHVASLGVDAIWLSPFFKSPMADMGYDVSDYRDVDPMFGTLEDFDALVAEAHRLGLKLIIDQVISHSSDKHEWFVESRAGDDSAKADWYVWADAKPDGSAPNNWQSLFGGPAWEWDATRRQYYMHNFLAAQPDLNFHNPEVQDALLDTVRFWLERGVDGFRLDTVNYYFHDRWLRDNPPLAASVAGTNGATTTYAFQEHLFDKTRPENLDFLKRFRALLDEYPDRAAVGEVGDEDRSLQTLAAYTSGGDKLQMCYTFDLLGPQFSAAHVRGCVEAFENAVADGWVCWAFSNHDVVRHVSRWTRPGENPDAVAKFSIALLACLRGSICLYQGEELGLDEAELAYEDLCDPLGIRFWPGVKGRDGCRTPMVWEAGAENGGFSTAKPWLPVPQAHRDRAVYVQNGEERSVLAAYRSILALRKRHAALVGGSIRFLDAEGDVLAFVRERDGESLLCLFNFAAADAGWALPPDIAVVEPIELAVDAGGVLDEGVLALPALGCFLGRIA
>CP034451.1|AZO09155.1|1730444_1732037_-|peptide-ABC-transporter-substrate-binding-protein
MLKNMLKATVFATTLVLATGTFYTPAFAETVYNRGSAAEAETVDPHKTSTVYEADIIRDMFQGLVMHDQKTNLIPGAAESWTVSDDGLVYTFKLRKDGLWSDGSPVTAEDFVYSFHRLEDPATAAEYASMLYPVKGAEDFNTKKGKPEDMGVKAIDANTLEVTLKAPTPYFLEMLTHQATYPVNKASIDKLGADWIKPGKLVSNGAYTLAEWVPNDHLKLVKNPKFWDAGSVKMDVVNYIPTEDRSSAMKRFEAGELDSYGDLPTEQLADLKTKFGDQVRVGPYLGTYYYAIKTDKAPWDNVELRNAISMAIDRDFLAEKVWQNSMLPGYSMVPPGIEGYTPALAKYADMSQIDREDAAKKILEKLGYTPEHPLKMEIRYNTSENHKNTAVAIQEQLKPLGVEVTLLNTDTKTHYSFLEQKGNYDVARAAWIADYKDPETFLGISRKASGNNYSDYNSPAYEAAMDKAAAAGGKPEERMKDLAEAERVLVDDVGQIPLLYYSFHDIVSSKLHGFDDNVMDIHPSRFISKD
>CP034451.1|AZO09154.1|1729347_1730271_-|ABC-transporter-permease-subunit
MLRYVFRRLLTAIPTLFVIVTVAFFLIRVAPGGPFNQERGLSPEIRANLEAQFGLNDPLWLQYVHYLGNLLRGNFGPSYNLPDFTVTELFAKGLPISVQLGSSALVLALLLGSILGTIAALNQNKIADYSVIALATAGSTIPTFVIAPVIQLVFGLSWKLLPIGGWGDGAFINKVGPVLTLALPQIAIVARLMRGSMIESLRSHHIRTARALGLSDWSVVVKHALRGAVLPIVSFTGPAAAALLTGSIIVETIFSIPGVGRYFVDAALNRDYTLVMGTVVVIALFTIVFNLIVDLLYAVVDPRVRYD
>CP034451.1|AZO09153.1|1728230_1729355_-|ABC-transporter-permease-subunit
MTDLAAAVPEPIVGRSLWGNAWARLKRNRAAMLSLYYLALIAVISVFGPWFVPHEYTTIYGDYVRTPPSLSAYPKPDMIQGALTDAIKRMRVDIKDWHQDGDRIIVTVTSKKPIDDRSIRYLDRSDAFDGTRIESKSPDGLEATMSSAVKQQYFVFGTDNTGRDLLSRTLMAGRISLAIGLLAGVVAGVIGVIYGATAGFAGGRIDEVMMRIVDVLYSLPFIFFVIMLVVFFGRNFVLMFLAVGAVLWLDMARIVRGQALSIRRQEYVQAAEAMGVGQRGILLRHVIPNLLGPVVIYMTLLVPQVIILESFLSFLGLGVQEPMTSWGVLISVGAKNIGTANWLLLFPAFFLVSTLFALNFVGDGLRDALDPKDR
>CP034451.1|AZO09152.1|1726596_1728213_-|ABC-transporter-ATP-binding-protein
MASETILSVKDLRVRFQTLDGTVEAVKGINIKVNAGETVAVVGESGSGKSQTMMAAMSLLSSNGEATGAVDYRGQNLLTMTKSELNKVRGRKISMIFQEPMTSLDPLYTIGNQLIEPIRRHRGLDAQAAREEALKLLRLVHIPDPERRMKSYPHEMSGGQRQRVMIAMALANDPDILIADEPTTALDVTIQAQILMLLAELQRKLGMAIVFITHDLGIVRRFADRVYVMRQGEVVEEGEAEALFANPQHAYTKMLLAAEPSGTKGPPPANAPVLLEGRNVEVVFKIGGGFLGGEPLMLRAVDKISIRLRRNQTIGIVGESGSGKSTLGRALLRLLPSDGVIRFGDRDISEADRRAMRPLRRELQLVFQDPFGSLSPRMTVGQVITEGLLVHEPSLTSKQRDQRAVEALREVGLDPNARNRYPHEFSGGQRQRIAIARAMILKPKVVVLDEPTSALDRSVQKQIVELLRKLQADNELSYLFISHDLAVVRAMADYIIVMKQGKIVEEGPAEEIFGNPQAAYTQTLMNAAIDTTRFRMSA
>CP034451.1|AZO09162.1|1743189_1745652_-|glycogen/starch/alpha-glucan-phosphorylase
MTRAMTSEAPALDHPDPKTLANEVLLALKYRLGKDTTVATPYDWLTASIKVVRDRVVDQWIQATKEAYDKQEKRVYYLSLEFLIGRLMRDAFSNLGLMENMREALASLDVDLDLIAALEPDAALGNGGLGRLAACFMESMATVDIPAHGYGIRYANGMFRQEIHDGWQVELPETWLDHGNPWEFERRERSFEVGFGGSVESITSRDGRLERHVWKPTEHVLAVAYDTPVAGWRAKRVNTLRLWSGMPIDPILLDKFNAGDHIGALAESNKADALSRVLYPADSHMAGQELRLRQEYFFSTASLQDIVQRHLSQYGDLKSLPDKAAIHLNDTHPAVAVPELMRLLMDVHGMDFDQAWDVTKRTFGYTNHTLLPEALESWPVPLFERLLPRHMQIVYAINAQVLLEARATGKFSGDQIARISLIQENGDRRVRMGNLAFVGSHSINGVSALHTDLMKETVFADLHKLYPDRINNKTNGITPRRWLIQCNPGLTALAREAIGDRFMDDIEAIKGLDAFAGDAAFREKFAAVKRQNKTRLANLVADRLGIRLDPSALFDIQIKRIHEYKRQLLNILEAIALYDQIRSHPERDWMPRVKFFGGKAAPSYHNAKLIIKLANDVAKVINRDPAVRGLLKVVFLPNYNVSLAEVMMPAADLSEQISTAGMEASGTGNMKFALNGALTIGTLDGANVEIKQCVGDDNIFIFGLTTAEVAQRRGNGYDPRGVIESSPELAQAVAAISSGVFSPDDPNRYRELMNGLYQSDWFMVAADFDSYAACQREVDAVWRNSPDWQARAIRNVARVGWFSSDRTIRQYAKEIWNVPV
>CP034451.1|AZO09163.1|1745790_1746573_-|sugar-ABC-transporter-ATP-binding-protein
MTQQPVLTARNLTKRYGRVTALNACDFDLYPGEILAVIGDNGAGKSTLIKAISGAVIPDEGTIELDGKQVLFRSPIEAREAGIETVYQNLALSPALSIADNMFLGREIRKPGPLGSWFRMLDRPAMEKRARDKLTELGLMTIQNISQAVETLSGGQRQGVAVARAAAFGSKVVIMDEPTAALGVKESRRVLELILDVKKRGLPIVLISHNMPHVFEVADRIHIHRLGRRLCVVDPKQISMSDAVALMTGAKKPPEDALAA
>CP034451.1|AZO09164.1|1746575_1747640_-|ABC-transporter-permease
MSQIQEFEKVLSGSDTSVASFDEHGKSFVKRAQHFLHSTPAAVPLIVLVLSIIIFGVAIGGRFFSSYTLTLILQQIAIVGILGAAQTLVILTAGIDLSIGVVMVISAVVMGNCAVSYGMPTILAVALGLAAGAACGLLNGLLVAYMKLPPFIVTLGTWNIVMATNFIYSANETIRDADVDAQAPLLHFFALSFRVGSAVLTAGVIAMVLLVMLLWYVLNHTAWGRHVYAVGDDPEAAKLSGIQTKKVLMAVYTLAGLIAAFAAWVSIGRNGSISPSAAVTDYNLQAITATVIGGISLFGGRGSILGTLFGAMIVGVVSMGLNMLGADPQWKVLLTGVLIIGAVAIDQWIRKVSV
>CP034451.1|AZO09165.1|1747801_1748836_-|sugar-ABC-transporter-substrate-binding-protein
MTKKSLLKSTVFAAAGLGLMAFASSASAAGVGACLITKTDTNPFFVKMKEGATAKAKELGVDLKTYAGKIDGDSESQVAAIESCIADGAKGILITASDTKGIVPTVKKARDAGLLVIALDTPLDPIDAADATFATDNLEAGKLIGAWAAATLGDKAKDAKIGFLDLTPSQPTVDVLRDQGFMIGYGIDPKDPNKIGDEDDPRIVGHDVTNGNEEGGRKAMENLLQKDNTINVIHTINEPAAVGAYQALKAVGLEKQVLIVSVDGGCPGVKSVAEGVIGATSQQYPLQMAALGIEAIAAYAKDGTKPKPTEGKNFFDTGVNLVTDKPANGVKSIDTKEGLAKCWG
>CP034451.1|AZO09166.1|1749045_1750272_+|ROK-family-transcriptional-regulator
METGIARHGSPEALESRMHRGTNQSGMRDHNERLVLSLVRQHGSLAKSDIARMTGLSAQTVSVIMRELEEDKLLLRQAPLRGKIGQPSIPMALNPEGAFFIGLKIGRRSAELVLIDFLGNVRAMLQNSYRYPAPRETVEFVTAGIKKMRGELTPAQDKRIAGLGIAMPFELWNWADTAGAPRDVMDEWRHRDIRADIQGQCDFPVYLQNDATSACGAELVFGQAGGARDFVYFYIGAFAGGGIVLNGRLFGGPTGNAGALGSMPVPGPDGKPTQLIDVASIAILEKALSAKGVDGSYLWTSPQEWGEIGAELDAWIAGAAQALAYAIVAASSVIDFEAAVIDGWMPLSVRRRLVDAVTDALAGIDAEGLKLPIVREGTVGIHARALGGASLPLSERFLVGPTSISRSA
>CP034451.1|AZO09167.1|1750273_1750720_+|transporter
MLIGIPSLLGPQLLATLRAMGHGDEVALVDGNYPAEEQARRLIRADGHHLIPVLDAILSVLPVDEAVPEALFRASVQGDPALADPVHHEMEAVCARRAPGRKVIALAGPDFYARVKTAHAIVATSEPRLYANIIIRKGVIHPPETDKT
>CP034451.1|AZO09168.1|1750716_1751640_+|carbohydrate-kinase
MILCCGEALIDMLPRTTTEGEAAFAPYVGGAVFNTAIALGRLGAPAGFFSGLSSDLFGGQLREALGASKVSSTYAHTSPKPTTLAFVRLTNGQATYTFYDENTAGRMLTIEDLPKLGAEIEAMLFGAISLISEPAGSAYEEFMRREHNSRVMMLDPNIRPNFIPDKAKHLRRIREMMAMADIVKLSDEDLNWFDEAGSHEDVIRNWLERGPKLIVVTHGSEGAVGYSKEHKVTVVPERVQVVDTVGAGDTFNAGILASLHEQGLLTKAGIGSLSEDAIRKALALGAKAAAVTVSRAGANPPWRHEID
>CP034451.1|AZO12944.1|1751893_1753036_+|DegT/DnrJ/EryC1/StrS-aminotransferase-family-protein
MQFIDLGAQRERIRDRLKAAIDHVVEDGRYILGPQVTEFENKLAAFVGVKHVVACANGTDALLLPLFAAGIGPGDAVFVPSFTFAATAEVVALAKAEPVFVDVDPSTYNIDIASLEAAIEIIKKQGRLKAKAIIPVDLFGLAADYEAITAIAKREGLLVIEDAAQSIGGSADGKMCGSFGHVASTSFYPAKPLGCYGDGGAMFTNDAALADKLRSFAFHGKGETQYDNILVGINSRLDTLQAAILIEKLAILEDEMVARQAVAQRYADGLGDIVKASRNLGHGRSAWAQYAIETPKRDGLKAHLTEKGIPSVIYYVKPLHAQVAYRDYPRSPAGLAVSEELPKQILCLPMHPYLSEADQDRIIETIRNYIGSNSASVAAA
>CP034451.1|AZO12945.1|1753156_1754002_-|3'(2'),5'-bisphosphate-nucleotidase
MLKTNMTMAAVSDDEAMLGVFERLALDAGREVMRVFHEGCAVDSKSDSSPVTEADRESEKIILAGLRAAYPHIPCVAEEEVAAGVATPDLDNAFFLIDPLDGTKEFVNRRTDFTVNIALIRHGVPEVGVVFAPCTGRFFSGRPGKAEMLEIDGEFHITGRQPIAVRAGGMPLAVVASRSHNTPETDAFIRDLGTADIVSVGSSLKFCLVAAAEADVYPRFGRTMEWDTAAGDAVLRAAGGMTRTLDGQPLVYGKRNQAGDSDFANPHFIATGKRATVNLPP
>CP034451.1|AZO09169.1|1753964_1755908_-|sulfate-adenylyltransferase-subunit-CysN
MNMRHIMAKSLAPTDGIRDYMAAQEKKSLLRFLTCGSVDDGKSTLIGRLLSDTKQIFEDQLAALERDSRKHGTTGDDVDFALLVDGLEAEREQGITIDVAYRFFATPKRKFIVADTPGHEQYTRNMATGASTADLAIVLIDARQGVLRQTRRHSIIASLLGIRHIILAVNKIDLVGFDESVFDRIVADYSEFAKGLGFTSIVPIPMSARYGDNVTNRSERTPWYSGPSLIEHLETVSVDEAAVELPFRFPVQYVNRPNLDFRGFAGTIASGTVSQGDEVVVAKSGRATRVKRIVAHGGDLKQAVAGQAVTLVLEDEVEVSRGNMLVSPAARPQVADQFTANIVWFDEQALLPGRSYILRTETDQVSATVTDLKYRVNVNDFAHEAAKSLDLNEVGVCNLSTRAPIAFDPFGENRTTGAFILIDRISNATVGAGMILHSLRRAENIHWQSLDVGKRGRSDLKNQRPAVFWFTGLSGSGKSTIANLFEKKLFASGRHTYILDGDNVRHGLNRDLGFTDADRVENIRRVAEVAKLMADAGLIVIVSFISPFSAERRMARELMAEGEFIEVFVDTPFEECARRDPKGLYARALSGEIKNFTGVDSPYEAPENPEIRLETLGKSPQEMAEALERWLDERDIAEDQYDNGGGI

Crispr_ID: CP034451_4

• CRISPR_ID: CP034451_4
• CRISPR_location: 2469850-2469944
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP034451_4

Consensus_repeat	Method
GTTTTCATCCATGCCGTTCCGCAAAACCGCTGC	CRISPRCasFinder

spacers of CP034451_4

>4.1|2469883|29|CP034451|CRISPRCasFinder
GCACTTTTGCGCGACATGCATAGGTCTTT

CRISPR arrays and Neighbor proteins around CP034451_4

CRISPR arrays

The CRISPR arrays of CP034451_4

>merge|CP034451|4|2469850-2469944|CRISPRCasFinder
GTTTTCATCCATGCCGTTCCGCAAAACCGCTGCGCACTTTTGCGCGACATGCATAGGTCTTTGTTTTCATCCATGCCGTTTCGCAAAACCGCTGC

>CP034451|4|4|2469850-2469944|CRISPRCasFinder
GTTTTCATCCATGCCGTTCCGCAAAACCGCTGC	GCACTTTTGCGCGACATGCATAGGTCTTT
GTTTTCATCCATGCCGTTTCGCAAAACCGCTGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP034451.1|AZO09722.1|2467328_2468621_+|histidinol-dehydrogenase	unknown	unknown	gnl|CDD|234853
CP034451.1|AZO09721.1|2466884_2467319_+|DUF2948-family-protein	unknown	unknown	gnl|CDD|371401
CP034451.1|AZO12993.1|2469329_2469740_+|low-molecular-weight-phosphatase-family-protein	unknown	unknown	gnl|CDD|223471
CP034451.1|AZO09717.1|2460023_2461166_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO12992.1|2464467_2464893_+|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO09716.1|2458661_2459267_-|recombinase-family-protein	unknown	unknown	gnl|CDD|239737
CP034451.1|AZO09720.1|2465395_2466688_+|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl|CDD|236486
CP034451.1|AZO09719.1|2463885_2464134_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197775
CP034451.1|AZO12998.1|2481355_2482618_-|sugar-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|224512
CP034451.1|AZO09727.1|2476688_2478710_+|asparagine-synthase-(glutamine-hydrolyzing)	unknown	unknown	gnl|CDD|273676
CP034451.1|AZO09726.1|2471347_2471569_+|DNA-gyrase-inhibitor-YacG	unknown	unknown	gnl|CDD|234943
CP034451.1|AZO12996.1|2478709_2480260_+|AMP-dependent-synthetase	unknown	unknown	gnl|CDD|211788
CP034451.1|AZO09724.1|2470341_2470560_+|translation-initiation-factor-IF-1	unknown	unknown	gnl|CDD|178954
CP034451.1|AZO09728.1|2480608_2481301_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	unknown	unknown	gnl|CDD|236467
CP034451.1|AZO12994.1|2472967_2475703_+|AMP-dependent-synthetase	unknown	unknown	gnl|CDD|341253
CP034451.1|AZO09718.1|2461237_2462959_-|hypothetical-protein	unknown	unknown	gnl|CDD|271184
CP034451.1|AZO12995.1|2475723_2476683_+|NAD(+)-synthase	unknown	unknown	gnl|CDD|179150
CP034451.1|AZO09725.1|2470691_2471318_+|Maf-like-protein	unknown	unknown	gnl|CDD|167232
CP034451.1|AZO09723.1|2468623_2469109_+|UPF0262-family-protein	unknown	unknown	gnl|CDD|235077
CP034451.1|AZO12997.1|2480321_2480588_+|acyl-carrier-protein	unknown	unknown	gnl|CDD|223314

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP034451.1|AZO09722.1|2467328_2468621_+|histidinol-dehydrogenase	gnl|CDD|234853	PRK00877, hisD, bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Reviewed.	0
CP034451.1|AZO09721.1|2466884_2467319_+|DUF2948-family-protein	gnl|CDD|371401	pfam11164, DUF2948, Protein of unknown function (DUF2948). This family of proteins with unknown function appear to be restricted to Proteobacteria.	6.08451e-67
CP034451.1|AZO12993.1|2469329_2469740_+|low-molecular-weight-phosphatase-family-protein	gnl|CDD|223471	COG0394, Wzb, Protein-tyrosine-phosphatase [Signal transduction mechanisms].	3.41851e-37
CP034451.1|AZO12994.1|2472967_2475703_+|AMP-dependent-synthetase	gnl|CDD|341253	cd05930, A_NRPS, The adenylation domain of nonribosomal peptide synthetases (NRPS). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.	5.36152e-93
CP034451.1|AZO09716.1|2458661_2459267_-|recombinase-family-protein	gnl|CDD|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	2.39434e-51
CP034451.1|AZO09720.1|2465395_2466688_+|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl|CDD|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
CP034451.1|AZO09719.1|2463885_2464134_-|XRE-family-transcriptional-regulator	gnl|CDD|197775	smart00530, HTH_XRE, Helix-turn-helix XRE-family like proteins.	4.27013e-15
CP034451.1|AZO12998.1|2481355_2482618_-|sugar-ABC-transporter-substrate-binding-protein	gnl|CDD|224512	COG1596, Wza, Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis].	6.18634e-24
CP034451.1|AZO09727.1|2476688_2478710_+|asparagine-synthase-(glutamine-hydrolyzing)	gnl|CDD|273676	TIGR01536, Asparagine_synthetase_1, asparagine synthase (glutamine-hydrolyzing). This model describes the glutamine-hydrolysing asparagine synthase. A poorly conserved C-terminal extension was removed from the model. Bacterial members of the family tend to have a long, poorly conserved insert lacking from archaeal and eukaryotic sequences. Multiple isozymes have been demonstrated, such as in Bacillus subtilis. Long-branch members of the phylogenetic tree (which typically were also second or third candidate members from their genomes) were removed from the seed alignment and score below trusted cutoff. [Amino acid biosynthesis, Aspartate family].	2.71262e-151
CP034451.1|AZO09726.1|2471347_2471569_+|DNA-gyrase-inhibitor-YacG	gnl|CDD|234943	PRK01343, PRK01343, zinc-binding protein; Provisional.	1.45663e-27
CP034451.1|AZO12996.1|2478709_2480260_+|AMP-dependent-synthetase	gnl|CDD|211788	TIGR03098, ligase_PEP_1, acyl-CoA ligase (AMP-forming), exosortase A-associated. This group of proteins contains an AMP-binding domain (pfam00501) associated with acyl CoA-ligases. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present next to a decarboxylase enzyme. A number of sequences from Burkholderia species also hit this model, but the genomic context is obviously different. The hypothesis of a constant substrate for this family is only strong where the exosortase context is present.	1.26911e-153
CP034451.1|AZO09724.1|2470341_2470560_+|translation-initiation-factor-IF-1	gnl|CDD|178954	PRK00276, infA, translation initiation factor IF-1; Validated.	1.10566e-45
CP034451.1|AZO09728.1|2480608_2481301_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase	gnl|CDD|236467	PRK09328, PRK09328, N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional.	4.0222e-57
CP034451.1|AZO09718.1|2461237_2462959_-|hypothetical-protein	gnl|CDD|271184	cd01184, INT_C_like_1, Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain. Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain containing six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.	2.29789e-28
CP034451.1|AZO12995.1|2475723_2476683_+|NAD(+)-synthase	gnl|CDD|179150	PRK00876, nadE, NAD(+) synthase.	0
CP034451.1|AZO09725.1|2470691_2471318_+|Maf-like-protein	gnl|CDD|167232	PRK01441, PRK01441, Maf-like protein; Reviewed.	1.70393e-133
CP034451.1|AZO09723.1|2468623_2469109_+|UPF0262-family-protein	gnl|CDD|235077	PRK02853, PRK02853, hypothetical protein; Provisional.	1.24473e-104
CP034451.1|AZO12997.1|2480321_2480588_+|acyl-carrier-protein	gnl|CDD|223314	COG0236, AcpP, Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism].	1.52814e-08

Protein sequences

>CP034451.1|AZO12993.1|2469329_2469740_+|low-molecular-weight-phosphatase-family-protein
MNAVRSPMAEQLAKRMLPATVFVASAGVRGGERDPFVDAVLAEEGLTLGGRQPRTLDELEDDYFDLIVTMAPEAHHAALELTRSLAVEVEYWPMPDPTDTGGTRDQIMAAYRDLRERLRARIGKRFAAAEAKGAAD
>CP034451.1|AZO09723.1|2468623_2469109_+|UPF0262-family-protein
MSGHHQNRDRLIDVELDETIGRSTPDVEHERAVAIFDLIEENSFRPLNDDGAGPYRLKLSLAESRLVFAVSREDGADVVTHILSLTPLRRIVKDYYLICESYYEAIRSSTPSHIEAIDMGRRGLHNEGSQTLMDRLAGKIEIDFDTARRLFTLVCVLHWRG
>CP034451.1|AZO09722.1|2467328_2468621_+|histidinol-dehydrogenase
MAITLNQQDPDFEQRISAFLSTKREVSADVDAAVRDIIARVRGEGDKALADYTLRFDKADLGKLGVAVSSSDIAGAYAAADPATIEALTFARDRIRSHHERQKPRDDRYTDAAGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVERIVIVVPAPNGVINPLVLVAADLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVLVVADADNDPDWIAADLLAQAEHDVSAQSILITDSAGFGKAVEQAVERQLKSLPRAETAAASWRDFGAVILVPTLEASLPLVDRIAAEHVELAIDDAESFLTKMRNAGAVFVGRHTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILKLGPEQLRMLAPAAIALAKAEGLEAHGRSVGIRLNM
>CP034451.1|AZO09721.1|2466884_2467319_+|DUF2948-family-protein
MAALKLIALDDQDLGIVSAHVQDAVMKVSDLEYLPAAKRFVLTMNRFVWEAKSGFLRQHNERRRSVLHFDRVLGVKTSGIARNKPDEVLSLLAISFVAISRPAGIIELVFAGGGAIMLDVECIEARLADVGGAWEATSRPIHRA
>CP034451.1|AZO09720.1|2465395_2466688_+|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MDRIRIVGGNKLAGSIPISGAKNAALPLMIASLLTDDTLTLENVPHLADVEQLIRILGNHGVDYSVNGRREKQQEGYSRTINFSARNIVDTTAPYELVSKMRASFWVIGPLLARMGQAKVSLPGGCAIGTRPVDLFLEGLQALGAALDVDNGYVMAKTKNGRLEGNRFVFPKVSVGATHVLMMAASLAKGETVLENAAREPEIVNLAECLVAMGAKIHGAGTSTITIQGVEALSGARVRVIPDRIETGTYAMAVAMTGGDVVLEGARPDLLQSALDIIAETGAEITPTNAGIRVQRNGAGISPVDVTTAPFPAFPTDLQAQFMGLMTMAKGKSRITETIFENRFMHVQELARLGAHITLSGQTAIVDGVAKLKGAPVMATDLRASVSLVIAGLAAEGETTVNRVYHLDRGFERLEEKLSGCGAVIERISG
>CP034451.1|AZO12992.1|2464467_2464893_+|hypothetical-protein
MTRVQDQTALSLGGPRDYAVAREAEVFAMTEALKFQDSIPEVAATSLVGVIAKLEMIVGADRDIGDPTDFPWPHIASVLRDLKAIAGGLPVGRRSRERTRSDIAKHWESAVKLVAALKEESAAEHLIQSASATKFPSRGLS
>CP034451.1|AZO09719.1|2463885_2464134_-|XRE-family-transcriptional-regulator
MEIREAFAQNLRALRRARGLSQEELAHQAGIDRTYISALERNVYNASIDVVDRLAEVLGVDVAELLKRPSADPRRSKSELDE
>CP034451.1|AZO09718.1|2461237_2462959_-|hypothetical-protein
MRGLSKRKGSEVWQGKFRIPQRLWDRRDDLLKLGASGIGGSQEFTKSLGERDRSQATRVYRERLDAWERLLDAWQALLDHGPQSLSQMDAVRVAALGAARRWEAFKDNPLEAPVAAHGSFPRPVFVPSDTTRIHLAALSPEAREAARLEGTANARRLLDGGPIERAKALQDVRDGRGFPWCFPEFRAIGLAMMEDMRGSAITEDLGAAGITAADEWSRFLVGLEGMGAKGRLAASLEARLSGDLSEPAWVADAKQAAPPVSRPKGASAKGITFEAIIDTQATKRKAGQGSRPMPEKSVKKYKRIAEAFATHRGSDDAATVTVSEVEAWLDAMQDEAGVSNRTIADRLVAIGTIINWGKKQRDHRDAMAQAETISGRVELPSYMEKPADETSYTLEEARTVLLAARREEDASKRWLPWLCLYAGLRISEANTLRKSDFFQAEALWFFKVTSAGKRSLKTANSERRIPVHPALEAEGFLAWVEAAPQGQLFRDGATSLIGRWVRSKTVGLARPGLSPNHGLRHLFVGLSRRYGLEGSAAEYLAGHSTQAVHAKYGSSDVMLPGLAAEIRKIDPLL
>CP034451.1|AZO09717.1|2460023_2461166_-|hypothetical-protein
MEIRKLGEEFENLCDELLRAMGYTTTKNWRPIESWPQAADILALSNDERLSIDTKVVPANPPTLSELRDNVARSKALLSLVDQAGSHAVMLSCNVEPEHRGWAENNFAIKVWDRTHLVRELGRLAPEHTELTNRFVAFFRDLAGVEYVSDLARNFAVDAAQPHRLEAETGRIKLTGGEATFGTVGDPAREGRRLRKRLAGLRPGLDDAKAYEALVQEIVFYLFGDYLVDPRPQSRTQDGLDILDIVYRVRAGHPFWDTLTRDFRTRAIIFECKNYKEGITPAQIYSTERYVNVGALRSVCFLLSRKEPHEHAELAASGAMREGGKLFVLLHDKHLEQMLDIRQTQLRREAETGASDRDFANDPSEVLDQVIYDFLTRVSR
>CP034451.1|AZO09716.1|2458661_2459267_-|recombinase-family-protein
MKTPVTTPTGAGQLVGYARTSTTDQKAGLEAQLRDLTGAGCAKVFREELSSVAATRPELERTLDYVREGDTLIVTKLDRLARSVADLVEITARLRAKGVALRILAMNLDTGTPTGKLMLNLLGSIAEFERELMLERQREGIAKAKAEGKYKGRAPTAKRKAAEVIRLKAEGKTGDAIAQELGIGRASVFRILRAQTGTAAD
>CP034451.1|AZO09724.1|2470341_2470560_+|translation-initiation-factor-IF-1
MPKEEVLEFPGVVTELLPNAMFRVKLENEHEIIAHTAGRMRKNRIRVLTGDKVLVEMTPYDLTKGRITYRFK
>CP034451.1|AZO09725.1|2470691_2471318_+|Maf-like-protein
MSSLQKLVLASGSPRRIELLQQAGIEPDRILPADVDETPLRAEHPRSLAKRLSKDKAEKALASLKSEEGAGPAFILAADTVVAVGRRILPKAETIDDAVNCLGLLSGRSHRVYSGICLITPGGKLRQKLVETRVRFKRLPREEIDAYVASGEWRGKAGGYAVQGLAGSFVVKLVGSYTNVVGLPLYESVALLSGEGFKAYRNWQAARP
>CP034451.1|AZO09726.1|2471347_2471569_+|DNA-gyrase-inhibitor-YacG
MSLDDKVTPLRPKRPCPECGKPSAREHYPFCSARCKDIDLNRWLKGAYVIPGRDSEEEEDDSPTQGPSPEDGE
>CP034451.1|AZO12994.1|2472967_2475703_+|AMP-dependent-synthetase
MLPAYLKAPAADQDLDEAPLPAGSSKWEDVPDYALDHGGPVLRSYRPLPAGFAEIGIGPHLETAVRQYPHKIALHDGVNGLSYSALGTAVEILSRRIATAVAQGSPVGICQPYSVWSIVAMLATVAAGRISIPLNARDPSPRIQEIVSAAKLSAMLGMGDRPRDLPADVQWIDMAASAASESYLPAPLLPSPCVDKAAIVLYTSGSTGRPKGIVNSERSLLRRVQQYVDACHINSEDVFLPLTGLATIAGCREILTAILTGATLHLVELEATGLRGVRARMRDEGVTVIYLVPALLRTLMADAPEGTFRSLRVVRVGGEKVLWTDIALLRQAVPQQCVIQIGYSSTETTGSQWFLPSEQPNAEADAPVGRLLPGIAFAIVDEEGRPVPSGETGELVIKSPYVLLGHWENGAVLPAEADPDDPGKRIFPTGDLVRLDSQRLLRIIGRKGRQIKINGRRIEPAELERVMRSASSVQDAVAIVTEATELVAFAVPNDSAGPDFVDGLRQLIANTLPSPLRPLRLHRVGEIPRLSSGKIDLAKLGKMDLLARKPATTADPPSPGSDLKVRQVVQKAWSKVLNTRAAAGRWDEAGGDSLKLLHCVMEIENLIGQELGLESFTVGMSADEMVTAVAAAQATASGKAAPDHNPPLLFLFPGSVGYGPSLAAFASAMGKTAKVMPIRYPGLALILKGQNDLASMADAAVQQVNRAQPSGHVRLLGHSLGGAVALEVALRLLKAGRSVKFVGILDTSLEGERSRRWETIARTARRLRSNRISFHRVACRALAKIAVRTGYETRLARAIDHYTDGQFNGACFRIKLELQEVLRAQAFFRWLEQPKAPLPIQGTLFRCARPGMSRAIGWDRVFCDLQVISIVGTHIDLVVEPHVATNRPLIEKAVLQTYTPAESLRLEGQAA
>CP034451.1|AZO12995.1|2475723_2476683_+|NAD(+)-synthase
MLALDAAAEAERIVTATREQVLVTLRRRGVVVGLSGGIDSSVVASLCVRAFGRDKVLGIFMPERDSSGDSLRLGRVVAAQLGIDTLVEDIAPALDAIGAYRRQSEAIRSVVPDYDQGWKCKLVLTPVLKSQGLNITRLTVEDPDGNINTVRLSTAAYLQIVAATNYKQRIRKMTEYYHADRLGYAVAGTPNRLEFDQGFFVKQGDGIADVMPIVHLYKTQVYQLAEYLGVDEEIRRRPPTTDTFSMAQSQEEFYFALPYQLTDLCLYGVNHGVCADEVAAASGLTGGQVEKVFKDIEAKRRAARYLHARPLPSVPMDLD
>CP034451.1|AZO09727.1|2476688_2478710_+|asparagine-synthase-(glutamine-hydrolyzing)
MCGIAGILALNATAEPPSREALLRMAGALAHRGPDERGLYRDRRAGLAHARLSVVDLQLGQQPLADASGLTWIVFNGEIFNYLELRDRLIVLGHRFRTRSDTEVVLHAYQQWGEAVFERMNGQWALAIWDAVAGRLVLSRDRYGICPLHWCEHGGRLFFASEVKAIFAADVAIPRTFDPAGIDQIFTMWTVVAPQNVFQGIRELPPGHVRVYENGAAREHAFWQPRFPEIPGPDPDRFSGSLDEAVEEVGLALEAATALRIVQADVPVGCYLSGGLDSSLVATLGRRFAGQRFQTFSLRFADAEYDETRFQRLVAAQTGSEHHEVVVSRSDIAEVFPEVIRHTERPILRTAPAPLFLLSGLVRKHGIKVVLTGEGADEMFAGYDLFREGKVRRFWGRQPASTRRAGLLERLYPYLSRSPVRQQALARQFFGRNIHAHDMPGFAHDTRWRTTSAIKRLFCPDMRAASQRRDAVSELLSTLPAEFPQWSALAQDQYLEIRTLMSGYLLSSQGDRMLMAHSVEGRFPFLDDNVIALANALPDAYKLRGLDEKHVLKRVAAPILPPQIVARKKQPYRAPNALSFFAADAPAYIRDALSEAALRTAGVFDASSVEGLVGKCRARVGDGDMSNSDNMALVGVLSTQLLHQQFVATRPVGATRPDLSIDVDYEHRERELA
>CP034451.1|AZO12996.1|2478709_2480260_+|AMP-dependent-synthetase
MHGAVPLLHDYLIHSAGRLADKVALVCNGQRLTYGEIDERSNGMAQSLASGGVQRGDRVMIFADNTVETVVSFWAVLKANAVVCLVNPLTKSEKLDYLLNDCRPTALITDQHLRSAFVAPAQNCRSLRKVIVSGPIDDDELTRLPHGVRWEAAAERAPAAPARNSIDIDLAAIIYTSGSTGEPKGVMLTHRNMTAACTSIASYLELREDDVILNVLPLAFDYGLYQMLMAFRTGARLVLERSFAFPAQILKVIKEERVTGFPGVPTIFASLSELKSLKDHDFSSIRYVTNTAAALSLKHINMLKEIFSDARIYSMYGLTECKRCTYLPPEDLERKPLSVGIAIPNTEMWLVDENDKRVEPGTVGQLVIRGATVMKGYWGKPEATARKLKPGPLPGEQVLYTGDYCRMDADGYLYFIGRGDEIIKSRGEKVPPKEVENVLVNIPGVKEAAVVGVPDELLGQAVKAFVVIEQGRIVGERQLQMECQKRLESFMVPKSIVIVPSLPMTDTGKLKKVALS
>CP034451.1|AZO12997.1|2480321_2480588_+|acyl-carrier-protein
MLATRPAGDIYTKQIRDFLASNFYIADVKSLSTTQSLLDQGIVDSTGVLEVIGFIEETFGITVEDSELLPENLDSIQGIAQFIARKRG
>CP034451.1|AZO09728.1|2480608_2481301_-|peptide-chain-release-factor-N(5)-glutamine-methyltransferase
MSEDINVADAYSRGSAVFMGMEMLVASGALVPRPETELLGSTALDVLHQMNLPAPRVVDMCCGAGNLACAIARHVPSARVWASDVTDACAEVASRNVLHHGLADRVFVLKGDLFEALSALVPPATIDVVVCNPPYISEKRLEGDRSHLLALEPREAFAAGPYGIAIHMRVVKDAARYLRPGGALLFEVGLGQDRQVASLLERSWAYDNIGVVTNLAGEARVVIGYAKPQP
>CP034451.1|AZO12998.1|2481355_2482618_-|sugar-ABC-transporter-substrate-binding-protein
MVNLSRFLLTAVAVLATLPMAFAGDLSAAYRISPGDTVEIGITSIPGRTQRAVVQMDGTILLPDAGTISVGGLTSPELQTRLQAILPTKIFHMRMADGREQMAVVRPSDVTAIIAEYRPIYVTGDVLTPGQQAFRPLMTVRQAIAVAGGFSLLRSRSNQVGPDPTDLRRDYEMIWGEYTRDYFHSARLRAELQKQASFDMQPPQGSPLTPALAAGVAKAEAEALKLSLDNYQQEQSFVEKGARDAAAQVEALIKRAQDEADGVKADEEDLAQVTRLFKAGNLTNNRLADVRRAVLLSSTRALETSVELMRTRRLQDDFARQLERNENQRRIGLLNELRDTEVRLADISARLRAASQKLQPQGATAAPLSIAGETVRAQLTIIRKIDGQWRKQATDEDAEVAPGDTIEVRFSNELESAAAQ

Crispr_ID: CP034451_5

• CRISPR_ID: CP034451_5
• CRISPR_location: 5532102-5532181
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP034451_5

Consensus_repeat	Method
ACGGAAACCGCTTCACACTTTTCCT	CRISPRCasFinder

spacers of CP034451_5

>5.1|5532127|30|CP034451|CRISPRCasFinder
TGAGTTGCGTTGTTATGCGGCAATTCCGGA

CRISPR arrays and Neighbor proteins around CP034451_5

CRISPR arrays

The CRISPR arrays of CP034451_5

>merge|CP034451|5|5532102-5532181|CRISPRCasFinder
ACGGAAACCGCTTCACACTTTTCCTTGAGTTGCGTTGTTATGCGGCAATTCCGGACGGAAAACCGCTTCACACTTTTCCT

>CP034451|5|5|5532102-5532181|CRISPRCasFinder
ACGGAAACCGCTTCACACTTTTCCT	TGAGTTGCGTTGTTATGCGGCAATTCCGGA
CGGAAAACCGCTTCACACTTTTCCT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP034451.1|AZO12243.1|5531546_5532032_-|thioesterase	unknown	unknown	gnl|CDD|372545
CP034451.1|AZO12241.1|5528812_5529700_+|dienelactone-hydrolase-family-protein	unknown	unknown	gnl|CDD|223489
CP034451.1|AZO12250.1|5541291_5541489_-|DUF4169-family-protein	unknown	unknown	gnl|CDD|372717
CP034451.1|AZO12248.1|5539147_5540950_+|chloride-channel-protein	unknown	unknown	gnl|CDD|238233
CP034451.1|AZO12249.1|5541054_5541282_-|aryl-sulfate-sulfotransferase	unknown	unknown	gnl|CDD|226771
CP034451.1|AZO13186.1|5530719_5531196_+|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
CP034451.1|AZO12242.1|5531202_5531400_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO12253.1|5543011_5544217_+|Bcr/CflA-family-efflux-MFS-transporter	unknown	unknown	gnl|CDD|340878
CP034451.1|AZO12246.1|5534427_5538477_+|AsmA-family-protein	unknown	unknown	gnl|CDD|236545
CP034451.1|AZO12240.1|5528191_5528626_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO12238.1|5522923_5525689_-|ATP-dependent-DNA-helicase	unknown	unknown	gnl|CDD|223288
CP034451.1|AZO12237.1|5521252_5522740_-|hypothetical-protein	unknown	unknown	gnl|CDD|226675
CP034451.1|AZO12252.1|5542153_5542837_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379522
CP034451.1|AZO12251.1|5541505_5542036_-|hypothetical-protein	unknown	unknown	gnl|CDD|226335
CP034451.1|AZO12245.1|5533671_5534229_+|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO12247.1|5538528_5538960_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|378956
CP034451.1|AZO12236.1|5519917_5521126_+|MFS-transporter	unknown	unknown	gnl|CDD|340883
CP034451.1|AZO12239.1|5525869_5528185_+|glucose/quinate/shikimate-family-membrane-bound-PQQ-dependent-dehydrogenase	unknown	unknown	gnl|CDD|274418
CP034451.1|AZO12244.1|5532250_5533669_+|FAD-binding-protein	unknown	unknown	gnl|CDD|178402
CP034451.1|AZO13185.1|5529716_5530631_-|DMT-family-transporter	unknown	unknown	gnl|CDD|227339

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP034451.1|AZO12243.1|5531546_5532032_-|thioesterase	gnl|CDD|372545	pfam13279, 4HBT_2, Thioesterase-like superfamily. This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.	3.33362e-35
CP034451.1|AZO13186.1|5530719_5531196_+|Lrp/AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.48251e-33
CP034451.1|AZO12250.1|5541291_5541489_-|DUF4169-family-protein	gnl|CDD|372717	pfam13770, DUF4169, Domain of unknown function (DUF4169).	1.63701e-09
CP034451.1|AZO12252.1|5542153_5542837_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|379522	pfam14246, TetR_C_7, AefR-like transcriptional repressor, C-terminal region. This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae. It is found in association with pfam00440.	6.97106e-27
CP034451.1|AZO12249.1|5541054_5541282_-|aryl-sulfate-sulfotransferase	gnl|CDD|226771	COG4321, COG4321, Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only].	7.75352e-27
CP034451.1|AZO12241.1|5528812_5529700_+|dienelactone-hydrolase-family-protein	gnl|CDD|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	1.07706e-65
CP034451.1|AZO12248.1|5539147_5540950_+|chloride-channel-protein	gnl|CDD|238233	cd00400, Voltage_gated_ClC, CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This domain is found in the halogen ions (Cl-, Br- and I-) transport proteins of the ClC family. The ClC channels are found in all three kingdoms of life and perform a variety of functions including cellular excitability regulation, cell volume regulation, membrane potential stabilization, acidification of intracellular organelles, signal transduction, transepithelial transport in animals, and the extreme acid resistance response in eubacteria. They lack any structural or sequence similarity to other known ion channels and exhibit unique properties of ion permeation and gating. Unlike cation-selective ion channels, which form oligomers containing a single pore along the axis of symmetry, the ClC channels form two-pore homodimers with one pore per subunit without axial symmetry. Although lacking the typical voltage-sensor found in cation channels, all studied ClC channels are gated (opened and closed) by transmembrane voltage. The gating is conferred by the permeating ion itself, acting as the gating charge. In addition, eukaryotic and some prokaryotic ClC channels have two additional C-terminal CBS (cystathionine beta synthase) domains of putative regulatory function.	9.42744e-104
CP034451.1|AZO12253.1|5543011_5544217_+|Bcr/CflA-family-efflux-MFS-transporter	gnl|CDD|340878	cd17320, MFS_MdfA_MDR_like, Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.65569e-90
CP034451.1|AZO12246.1|5534427_5538477_+|AsmA-family-protein	gnl|CDD|236545	PRK09510, tolA, cell envelope integrity inner membrane protein TolA; Provisional.	3.59491e-35
CP034451.1|AZO12238.1|5522923_5525689_-|ATP-dependent-DNA-helicase	gnl|CDD|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	9.56512e-142
CP034451.1|AZO12237.1|5521252_5522740_-|hypothetical-protein	gnl|CDD|226675	COG4222, COG4222, Uncharacterized protein conserved in bacteria [Function unknown].	1.49658e-71
CP034451.1|AZO12251.1|5541505_5542036_-|hypothetical-protein	gnl|CDD|226335	COG3814, COG3814, Uncharacterized protein conserved in bacteria [Function unknown].	3.2679e-85
CP034451.1|AZO12247.1|5538528_5538960_-|MarR-family-transcriptional-regulator	gnl|CDD|378956	pfam12802, MarR_2, MarR family. The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	1.00747e-10
CP034451.1|AZO12236.1|5519917_5521126_+|MFS-transporter	gnl|CDD|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.16356e-18
CP034451.1|AZO12239.1|5525869_5528185_+|glucose/quinate/shikimate-family-membrane-bound-PQQ-dependent-dehydrogenase	gnl|CDD|274418	TIGR03074, PQQ_membr_DH, membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family. This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.	0
CP034451.1|AZO12244.1|5532250_5533669_+|FAD-binding-protein	gnl|CDD|178402	PLN02805, PLN02805, D-lactate dehydrogenase [cytochrome].	1.76101e-148
CP034451.1|AZO13185.1|5529716_5530631_-|DMT-family-transporter	gnl|CDD|227339	COG5006, rhtA, Threonine/homoserine efflux transporter [Amino acid transport and metabolism].	1.71216e-82

Protein sequences

>CP034451.1|AZO12243.1|5531546_5532032_-|thioesterase
MTIPAPFISRAMDIEKDWIDYNGHLNMAYYNVLFDRCSDEAFELMGMGPNYAKERRLTIYTAEVHVCYVQELHLDHKVKVSFQLIDHDEKRLRAYQEIRHVDGWLAATSESLSLHVDMSGPKVAPFPADVLARIEAMRAAHAALPMPERAGRSIGIKRKSA
>CP034451.1|AZO12242.1|5531202_5531400_-|hypothetical-protein
MKTDIKVEVERLAADPRITDYDFWRSLKNVNNEIFHIANNNEPIPFEMIRWRAILKQARMKRGHA
>CP034451.1|AZO13186.1|5530719_5531196_+|Lrp/AsnC-family-transcriptional-regulator
MKRLRNENTDLDRADLKILRLLEKDARTSTAELARAVGLSAPSVAERIRKLQESGVIEAYTVRINPAALGMKLSAWLRIRPVPGQLSIVTEIIRELPEIAQCDRVAGEDCFIALAHVGSVTDLERVIDRIIPYAMTNTAIIQSSPVEPRSPLGILKEG
>CP034451.1|AZO13185.1|5529716_5530631_-|DMT-family-transporter
MKPQGQVPAANVITREGDAPRPARSGWSDALPPHVWFCVSAVFHYLGPAFAVLLFAQVGVLGMAWLRIATAALVFMPLTKPWRVFAHADRSARLLLLAFGACLAVMNCSFYLALDRLPISLVAAIEFVGTIGVALVGLRSQRNFLALTIAVAGTLLLIDVKWSSDPVGLFWAFLNGALFVAYIVIGHRLAQTGTGIAGLGAAMAIAFLVVFPIGFSEALPAFSAPQLLFAAVGVGVCSSVIPYICDQLAMAQLPRASFALMLSLLPLTATLIGVLVLRQVPSLIECLGIMLVVTGVAVHKPLQA
>CP034451.1|AZO12241.1|5528812_5529700_+|dienelactone-hydrolase-family-protein
MTEPVAKPVITQAMIDAYDEYTHLTLDRRRFMEQLTKLAGSGAAAAAIAPMLAANSAQAAIVADNDPRVKGQDITYPGSSGEMKGYLVKPAGQSGRLGTVIVVHENRGLNPHMRDVARRVALEGFVALAPDFLSPLGGTPADEDKARDLFTKLDAKQVTADGVATVAYLKGDKDGNGKVGAIGFCWGGGAVNALAVNAPDLSAGVAYYGMQPKAEDVPKIKAALLLHYAGLDERIDAGIDAYKKALDAAHVEYTLHVYEGVNHAFNNDTSAARYDKKAADLAWARTIAFLKEKLA
>CP034451.1|AZO12240.1|5528191_5528626_-|hypothetical-protein
MNVQDIVNTVSQKAGLDQATTEKVVGTIFSVLEYEAEGTSVSSFFDKIPGAGALAQQYDVMAAGAAGSGGGLLSSLQGALGGVLGEKAGALINGVAALKASGLDMAQIRQAGETLIKQAEAAAGPDLTNQVLGQVPSLRGHLGL
>CP034451.1|AZO12239.1|5525869_5528185_+|glucose/quinate/shikimate-family-membrane-bound-PQQ-dependent-dehydrogenase
MAVTFTSVVLLLIGLAVGGGGIWLVTLGGSWYYLIAGLAFVVTAWLIFRRSSAGLWLYAAIVLATLCWAVWETGFDWWQLGPRGGVIVLIALWLLTPWARRGFTGPDGRAPLILAVLASLAVAGYSMTADPKDIGGTLGTDKVTPTANLGGDMPAGEWHFYGRTPFGQRYSPLDQITPDNVARLQPAWTYRTGDVKGPDDIGETTYQVTPLKIGDVLFICTPHNFAIAVDAATGKEKWRYDPKIKLDPNRQHQTCRGVSYYADPKIAAGQPCASRIYLPTSDARLIALDAANGQVCPSFAEGGTLNLMANMPYPKSGYYYSTSAPLIVAGKIIVGGAVNDNYSTEEPSGVIRAYDAGTGALLWNWDSGNPDQTAPLPAGQDYTNNSPNMWSTPSADEKLGLLYVPLGNQTPDQLGMGRSANVEKFSSSITALDLNTGQLRWVRQTVHHDLWDMDVPAQPILVDITTQSGEVPALVGPTKQGDIYVLDRRSGEPIVPVKEVPAPGGAIEGDHTSPTQPASDLSFNPKALTGADMWGITMFDQLACRIELKKLRYEGRYTPPSLQGSLVYPGNFGVFNWGGVAVDPLRQVMFGMPTYLAFTSKLIPRAEVPPPGDNAKGSEQGLNRNEGAPYAVVMGPFLSPLGIPCQAPPWGYVAGVDLRTGNIAYKHRNGTVYDMTPLPLPFKVGVPGIGGPMITAGGVAFLGATVDDFLRAYDLTSGRQLWKARLPAGGQSTPMTYTVADGRQFVVIVAGGHGSVGTKPGDYVMAYSLPQ
>CP034451.1|AZO12238.1|5522923_5525689_-|ATP-dependent-DNA-helicase
MPGFSEDMPFFDEPNARPAAPSGIAARAMAARSAQNRAPDYLNGLNPEQRLAVETTEGPVLVLAGAGTGKTRVLTTRIAHILNTKKAWPSEILAVTFTNKAAREMKQRIGLLIGDENVEGMPWLGTFHSIGVKLLRRHAELAGLKSDFTILDTDDVVRLIKQIIQAEGLDDKRWPAKQFAQMIDNWKNKGLGPDEIAEGDARSFGNGKGRQLYRAYQERLQTLNSCDFGDLLYHPIRIFRAYPDVLKDYHRKFKYILVDEYQDTNTAQYMWLRLLAQRPGTSRNGTPGGRTPGATKSTIDRTEGGHYRPPVPEEEPLARSDEWDISAEGRKPDRASEPLRGPRRGPAPAGAEQPVSVNICCVGDDDQSIYGWRGAEVDNILRFDKDFPGATIIRLERNYRSTAHILGAASHLIAHNEGRFGKTLFTDRNDPEDDKVHVHAAWDSEEEARAIGETIEAYQRPDREGNRHNLNDMAILVRASFQMRAFEERFITLGLSYRVIGGPRFYERLEIRDALAFFRVVANSGDDLAFERIVNVPKRGLGEATIRQMHDTARAMRIPMLEAAATLAESDELKPKPRAALREVAANFERWQKALETTPHTELAETILEESGYTDMWKNDRSAEAPGRLENLKELIRSMEEYESLRAFLEHVALVMEAEQGESLDAVSIMTLHSAKGLEFETVFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGLTRAKKNLHIWFVSNRLIHGLWQSTIPSRFLDELPETHVDVADSGSSYGGYGNPYGGGSFASGRGGGRQNPYGASRFDNIGTEKSGSFSNTYATPGWQRAQANRTEATDRNWGTRSGHQVERIGYGETDSGYGAGRTSVKGRTIEGELVAKSVADTPSPFKLGDRVFHQKFGNGNIAAIDGNKLTIDFDKAGQKRVLDGFVTGV
>CP034451.1|AZO12237.1|5521252_5522740_-|hypothetical-protein
MKTLRPSGYWLIAATLAASAVSHPALADGTAYVNKGLVGVGRIPASQKDKFGETFGSGSGMAIDTRSWTRDGATYKGSLWLLPDRGYNVVGTTDYRPRLNTISIELAPTASGAAPAAGQEQSGVKPTVADTILLTDDKGVDATGLDPLNGVRAAAGDMPMLPQADNGKLALDDEAIVRLPDGTMFISDEYGPNIYRFSADGHLMSATQPPAALVPTRHGKPNFASDNPGAGAAEPDPKDPDTGRQNNQGLEGMSMTPDGKFLIAVLQSATRQDGGDSGSTRQNTRALVYDTSDLAHLKLAHEYVVPLPVFKDAKGKTKVAAQSEIVALSDNSFLMLARDSGNGQGVKGDESIYRKIDIVDLSGATDIANGPFDAADKPVAAKGVLDPSVTPAKLTTFIDINDKAELGRFGLHNGAPNDRNNLSEKWEAMSLVSVLDPKLPDDYFLFVANDNDFLTQDGFQVGAAYKAEDGADVDTTFLVYQVTLPGLSGNSLAAN
>CP034451.1|AZO12236.1|5519917_5521126_+|MFS-transporter
MTSYTQTMPRDNEIGGRAGTAAVAAMIAALFAGSTALTPLYVIYKQAFGFSQITLTLVYAVYVVGNLAALLFFGRLSDVVGRRPAALAAMAVAVVSALFFLFAENLAWLDIARILSGLGIGVGAGTGTAWLAELIEGEDKSRAAIIATSTNFIGLGVGALLSGVLAQYAPWPLRLTFGVYLVVLALITLLIWRTQETVSRPGRISDVSMRPRLSVPDSIRAQFVAPAVTGFGAMALVGFYAALAPSILAQQLNATSHAEAGGLFFELSIVAAATILVTARLPSRFTMLAALVLMIPTVALIVAAQVFASMAIMIVATALCGVAAALGYRGGLQVVNQIAPGNRRAEVVSAFFICCFCGNALPVIGIGILSSLASATAASLAFAGMITIFSMVALGFGAKYAK
>CP034451.1|AZO12244.1|5532250_5533669_+|FAD-binding-protein
MALSDLNPVERNEEGIAAVLGILKQQFGERFQTGEAIRSQHAHTTTYIPTQAPDGVVFVETTPEVQEIVRACAAHRVPVIPFGIGSSLEGHTNAPGGGVSVDTSRMNRILAVNPQDLDCTVEPGVTREDLNRHLRDTGLFFPIDPGANASLGGMAATRASGTNAVRYGTMRENVLSLTAVMADGEAVTTGKRAKKSSAGYDLTRLLVGSEGTLGIITSLTLRLQGIPQAISGGVCPFPSLEAACNTVIATIQMGIPVARIELVNALQMRAMKAYSKLDYPESPCLFVEFHGSDAGVAEQAETFGMIAEEQGGGSFLWTSVAEERTKLWKARHDAYWSSLTLRPGAKGLSTDVCVPISRLAECVTETEADIAEMGLIAPIVGHAGDGNFHVLVLMDTDSPEEIALAEKFVARLNMRAIAMEGTCTGEHGVGQGKIGFLRHELGHGVDVMRTIKQALDPFNIMNPGKILPGARQ
>CP034451.1|AZO12245.1|5533671_5534229_+|hypothetical-protein
MSEAENLAPIDLPLSSAGAPLPHVFAVEGRLLIAYIVSVPDRGFDGTNARSVSPSTRGQSVAILTADPYLAVQFGPPNDEALSGHRLYGLGLQPYSAFEVRNSSWIGSLEKANRVHPSHMPELFSGYRHFILTFHDSTLEFVAKDFAVSLRRGAILTALMEIIGHNVSADRVKPTGFFTRLLRRG
>CP034451.1|AZO12246.1|5534427_5538477_+|AsmA-family-protein
MLARLFVIFGGLFVLVLCAALVVPYFIDWTSYRADFEREASVILGRKVTVKGDATARLLPFPSVTFSNVEVAGGPGGQPAMTVETFSMDAELAPFLRGELLIFDMRLVHPKGTIDVAADGTVDWAIRPSTPFDPGQIAIEKLTVTEGQIELRHAAGGRSHLISEINAAVSAKSLAGPWRMDGSLRFDGLGAQVSASTGKVEADGRMRLRLKANPAGYPMVVESDGNAGIVKGAAAYSGQFKITSSDNTGTDGNTAELRGTDGEPVKVSAGKPDPGFRINGKFALNHQKLGIDEFRFETGPLDNPYTADGKASVDLGPKPRFSIEASGAQVQFDEAVGAAAGTGLTLDQRMAGLEQTLLHMPKPTIPGTVEVRLPAVVAGDTTVRDVRLSAEPVEGGWSVKSLAATLPGRATLEADGMLSVEDHFGFEGSLLLAVGQPSGFAAWLSKDVDDAIRRLPAAGFHAKVDLSENRQTFSDLELVLGKARFSGSIDSSQPDGARPSVLMRLEGGDLDVDGLAAFASIFVSDKGANRFSDRDLDFQIRAGPVSAGGLTADTVDTALRLRQGLLEIDRLSVGGLAGASISATGRVKDFPESPTGKLDASVVAVDLKPLIDVAAQHYPGNAVLKGLAARAAAYPELFQDARIDLLTSAADNGDGTTGLALSAQGKAGGSAFSASLSGKGTADRLLDAPVALTFNARNANATTLLALYGLPALPLGMLGQATTDLSAKGTLGGGLATSFSLTADDFRVGFLGTIADPPQGAIAKGKVSLDAADIEPWLMTTGIGLPGMGTGTSTSLAADADFANGLLVLSSLNGSINKSAVSGDVNVDVKDGLPHLAGALALDELDLDPLAVSLFGDQSFMAAKGGWPAAPFSQKSSLPFSADLDLDTAALAAGPFAMARDASLTLKLDSEGIRVSDLKAKLYGGELTGLFELKNTDGTGLFSGQMKLAGGDLSAVLPETGINGAADISASLSTSGKSVDAMIAALSGSGTAALKGLHIAGINPDAFAAIIAKADVIGRDMDAARTAGFAPQIVGDGNFAAGDAEIAFTVAGGVLRAPPISLDNPAATLSADVTADLVGGSVTANGTIHYRAGDEAMVGSEPSMNFSVAGPLGATARQFDSEPLAQFLTQRALEKEQQRVEAMQASLLEKQRLRREARYYAALQTERERAAEELRRQEEEARQKAEAEAKAKAEAEAQAKAEAEAQAKAEQEARARAEAEAKAQAEAEAQARAEAEAKARAEEEARAKAEAEAKAQAEAQAKAEAEAKARAEEEAKAKGAADEAAKAQAAADRKKAEQARLEAERKAAEQKPKVDRSLPGVNDDSAPVLPKPNANPFTIENLLKSLDGG
>CP034451.1|AZO12247.1|5538528_5538960_-|MarR-family-transcriptional-regulator
MTHSQKPRPSISQAEYQRLSEFRYLIRRFLEFSQLQANEAGLTPRQHQALLAIKGYPSGGPVTVGDLAERLRIRHHSAVELVNRLCEAGLVTRDQDKADNRRVLLQLTPLADDRLADLSAAHLDELSRIEPMLRRLLSRREQP
>CP034451.1|AZO12248.1|5539147_5540950_+|chloride-channel-protein
MKTSHAGNGHLRDFTTDARVLVIAAIAVVVATAGLFAGIVLLKLIRLSTNIAYFGQFSLAELRLEDTPLGYGAVIVPVIGALIIGLMARFGSEKIRGHGIPEAIEAILLGRSRLDAKVAVLKPLSSAISIGSGGPFGAEGPIIMTGGAIGSLIAQMLPVSDNERKTLLVAGAAAGMTTVFGTPIAAIMLAVELLLFEWTPRSFIPVAVAAIIAEVERTLLHLPGPIFPFAGSMEASVAGLGGWVLIGIAAGLLSGLLTQMVYACEDAFQKLPIHWMWWPMIGGLVVGIGGLIEPQALGVGYDNIVNMLDGRIVAGAALLLLVVKAIIWSVALGSGTSGGVLAPLLIMGGAMGAVLAGILPEATPGFWPLLAMAATMGGTMRAPLTATFFAVELTGNTHMLVPLIAACATAHAVTVLLMKRSILTEKVARRGHHLVREYRVDPFALTRVREVMTTEVESVPSTMTLHGAAAFLTAPHTRHPSFPVINQDGHVLGLIDPPAILRWRRAGKHRKTTLGELLTGSKVTLAYPDEYLEGLSDKLLLANVSHLPVVSRDEQRLVGYVGWKDLMRVRSKKQAEERERSALLSFGAKRKARQSAGDPV
>CP034451.1|AZO12249.1|5541054_5541282_-|aryl-sulfate-sulfotransferase
MAAVEKRSVTIRGHRTSFSLEQPFYDDLVAIAGARSISLAALVAEIDETRTRDANLSSALRLYVLAWAKRGGKPP
>CP034451.1|AZO12250.1|5541291_5541489_-|DUF4169-family-protein
MGDVVNLRQARKQKARIEKERQAGRNRTLHGRSKAERERDRLTSDRVEKFMDGHRREKPGDPGER
>CP034451.1|AZO12251.1|5541505_5542036_-|hypothetical-protein
MADDHIRYDILAQEALRGVMRKVLAEVARTGLPGNHHFFITFLTGAPGVRISSRLRERYPEQMTIVIQFQYWDLKVTDTGFEVGLSFSDVPERLEIPFSAVRGFYDPSVNFELEFDVRSEGSAEDEAPTPPEPVAVVAEKKPETKKKAAEAEKKTAVADPGGKSADVVSLDAFRKK
>CP034451.1|AZO12252.1|5542153_5542837_-|TetR/AcrR-family-transcriptional-regulator
MKPSVSPDTFPPRSHEAKRISVVGAAASVFCREGYAGANIDLIAAEAGVSRQTIYNHHRDKEKLFMAVVRDLTERCNAGIFATIATFPDQPADLEADLIAFAVRMNRNCICNRDGRFLRKLIQAEGERYPELFAEWREQGPGRTWSALAARFARLAYAGHLAIDDPDVAARQFLALVNAELQITFMLGGTPTDDEVLQSATHGVRTFLAAFGLPKVAAVRKAALAHA
>CP034451.1|AZO12253.1|5543011_5544217_+|Bcr/CflA-family-efflux-MFS-transporter
MNPKFLRIAVVLGLLSAIGPFAIDMYLPALPSIGQDLHAGTAAVQMSLLIFFLSMGFGQIVVGPISDMVGRKLPLYAGLALFMVGGVGSAMAPTIEWLIAFRFLQGLGASAGMAVPRAIVRDLHTGNEAAKLMSLLMLVFSVSPILAPLTGSQIIESFGWRAVFWTVTGAAALATILLATSLRETRSVEERAGSSFGTALSAYRYLLGDLNFLGLTAIAGFGIASFFVYLSSSSFILIDHYGLSPSVYSVFFSINAVAFIGMSQLTGLLADRFGLKRVVWVAVTGYATVMVALFAIMASGVDRLDVMAVMLFVGYGFLGLVIPTTSVLAMEEHGEIAGTASALMGTLHFAIGALAMGVAGVFFDGTPLPMVAGITLCAVIAFSLAKVTLGRAREAVEAPAE

Crispr_ID: CP034451_6

• CRISPR_ID: CP034451_6
• CRISPR_location: 5588063-5588207
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP034451_6

Consensus_repeat	Method
GATCGCCAAGAACAAGCTGGTCGACAAGGCCAAGAACTAAAGCGA	CRISPRCasFinder

spacers of CP034451_6

>6.1|5588108|55|CP034451|CRISPRCasFinder
CCCGCGCTCCATTGCCTTGCGCGTCCTCGGGCTTTGCCCTGCGGTCGCGCGGGGC

CRISPR arrays and Neighbor proteins around CP034451_6

CRISPR arrays

The CRISPR arrays of CP034451_6

>merge|CP034451|6|5588063-5588207|CRISPRCasFinder
GATCGCCAAGAACAAGCTGGTCGACAAGGCCAAGAACTAAAGCGACCCGCGCTCCATTGCCTTGCGCGTCCTCGGGCTTTGCCCTGCGGTCGCGCGGGGCGATCGCCAAGAACAAGCTGGTCGACAAGGCCAAGAACTAAAGCGA

>CP034451|6|6|5588063-5588207|CRISPRCasFinder
GATCGCCAAGAACAAGCTGGTCGACAAGGCCAAGAACTAAAGCGA	CCCGCGCTCCATTGCCTTGCGCGTCCTCGGGCTTTGCCCTGCGGTCGCGCGGGGC
GATCGCCAAGAACAAGCTGGTCGACAAGGCCAAGAACTAAAGCGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP034451.1|AZO12302.1|5593716_5595006_-|efflux-RND-transporter-periplasmic-adaptor-subunit	unknown	unknown	gnl|CDD|183211
CP034451.1|AZO12301.1|5593007_5593712_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|213222
CP034451.1|AZO12298.1|5590751_5591468_+|hypothetical-protein	unknown	unknown	gnl|CDD|320361
CP034451.1|AZO12286.1|5577812_5579729_+|potassium-transporter-Kup	unknown	unknown	gnl|CDD|225700
CP034451.1|AZO12284.1|5576374_5576776_-|STAS/SEC14-domain-containing-protein	unknown	unknown	gnl|CDD|378774
CP034451.1|AZO12299.1|5591481_5591712_-|hypothetical-protein	unknown	unknown	unknown
CP034451.1|AZO12297.1|5589636_5590749_+|endonuclease	unknown	unknown	gnl|CDD|225249
CP034451.1|AZO12285.1|5576979_5577720_+|pyridoxine-5'-phosphate-synthase	unknown	unknown	gnl|CDD|223923
CP034451.1|AZO12290.1|5583388_5584618_+|FAD-dependent-monooxygenase	unknown	unknown	gnl|CDD|223727
CP034451.1|AZO12304.1|5596349_5597360_-|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase	unknown	unknown	gnl|CDD|274459
CP034451.1|AZO12300.1|5591793_5593011_-|FtsX-like-permease-family-protein	unknown	unknown	gnl|CDD|182528
CP034451.1|AZO12287.1|5579875_5581792_+|potassium-transporter-Kup	unknown	unknown	gnl|CDD|225700
CP034451.1|AZO12303.1|5595141_5596044_+|PhzF-family-phenazine-biosynthesis-protein	unknown	unknown	gnl|CDD|223461
CP034451.1|AZO12292.1|5585286_5585592_-|Rieske-(2Fe-2S)-protein	unknown	unknown	gnl|CDD|225057
CP034451.1|AZO12296.1|5588888_5589473_-|BA14K-family-protein	unknown	unknown	gnl|CDD|369573
CP034451.1|AZO12288.1|5581858_5582752_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187578
CP034451.1|AZO12295.1|5588432_5588717_-|PilZ-domain-containing-protein	unknown	unknown	unknown
CP034451.1|AZO12291.1|5584571_5585303_-|glutathione-S-transferase-family-protein	unknown	unknown	gnl|CDD|223698
CP034451.1|AZO12293.1|5586276_5586954_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
CP034451.1|AZO12289.1|5582888_5583296_+|transcriptional-regulator	unknown	unknown	gnl|CDD|224647

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP034451.1|AZO12302.1|5593716_5595006_-|efflux-RND-transporter-periplasmic-adaptor-subunit	gnl|CDD|183211	PRK11578, PRK11578, macrolide transporter subunit MacA; Provisional.	1.16314e-46
CP034451.1|AZO12301.1|5593007_5593712_-|ABC-transporter-ATP-binding-protein	gnl|CDD|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.19949e-109
CP034451.1|AZO12298.1|5590751_5591468_+|hypothetical-protein	gnl|CDD|320361	cd15233, 7tmA_OR3A-like, olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors. This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.	0.0062418
CP034451.1|AZO12286.1|5577812_5579729_+|potassium-transporter-Kup	gnl|CDD|225700	COG3158, Kup, K+ transporter [Inorganic ion transport and metabolism].	0
CP034451.1|AZO12284.1|5576374_5576776_-|STAS/SEC14-domain-containing-protein	gnl|CDD|378774	pfam11964, SpoIIAA-like, SpoIIAA-like. These proteins adopt an alpha/beta SpoIIAA-like fold, similar to that found in STAT (pfam01740). They adopt open and closed conformations arising from different arrangements of their alpha-2 and alpha-3 helices. They may be membrane associated and may function as carriers of non-polar compounds.	3.55585e-11
CP034451.1|AZO12297.1|5589636_5590749_+|endonuclease	gnl|CDD|225249	COG2374, COG2374, Predicted extracellular nuclease [General function prediction only].	1.50795e-12
CP034451.1|AZO12285.1|5576979_5577720_+|pyridoxine-5'-phosphate-synthase	gnl|CDD|223923	COG0854, PdxJ, Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism].	1.07661e-122
CP034451.1|AZO12290.1|5583388_5584618_+|FAD-dependent-monooxygenase	gnl|CDD|223727	COG0654, UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion].	1.61504e-59
CP034451.1|AZO12304.1|5596349_5597360_-|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase	gnl|CDD|274459	TIGR03160, cobT_DBIPRT, nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase. Members of this family are nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, an enzyme of cobalamin biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin].	3.41654e-145
CP034451.1|AZO12300.1|5591793_5593011_-|FtsX-like-permease-family-protein	gnl|CDD|182528	PRK10535, PRK10535, macrolide ABC transporter ATP-binding protein/permease MacB.	8.92082e-61
CP034451.1|AZO12287.1|5579875_5581792_+|potassium-transporter-Kup	gnl|CDD|225700	COG3158, Kup, K+ transporter [Inorganic ion transport and metabolism].	0
CP034451.1|AZO12303.1|5595141_5596044_+|PhzF-family-phenazine-biosynthesis-protein	gnl|CDD|223461	COG0384, COG0384, Predicted epimerase, PhzC/PhzF homolog [General function prediction only].	2.63434e-111
CP034451.1|AZO12292.1|5585286_5585592_-|Rieske-(2Fe-2S)-protein	gnl|CDD|225057	COG2146, {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only].	1.52667e-23
CP034451.1|AZO12296.1|5588888_5589473_-|BA14K-family-protein	gnl|CDD|369573	pfam07886, BA14K, BA14K-like protein. The sequences found in this family are similar to the BA14K proteins expressed by Brucella abortus and by Brucella suis. BA14K was found to be strongly immunoreactive; it induces both humoral and cellular responses in hosts throughout the infective process.	7.20106e-11
CP034451.1|AZO12288.1|5581858_5582752_-|SDR-family-oxidoreductase	gnl|CDD|187578	cd05269, TMR_SDR_a, triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs. TMR is an atypical NADP-binding protein of the SDR family. It lacks the active site residues of the SDRs but has a glycine rich NAD(P)-binding motif that matches the extended SDRs. Proteins in this subgroup however, are more similar in length to the classical SDRs. TMR was identified as a reducer of triphenylmethane dyes, important environmental pollutants. This subgroup also includes Escherichia coli NADPH-dependent quinine oxidoreductase (QOR2), which catalyzes two-electron reduction of quinone; but is unlikely to play a major role in protecting against quinone cytotoxicity. Atypical SDRs are distinct from classical SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	3.53774e-99
CP034451.1|AZO12291.1|5584571_5585303_-|glutathione-S-transferase-family-protein	gnl|CDD|223698	COG0625, Gst, Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	2.93837e-32
CP034451.1|AZO12293.1|5586276_5586954_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	3.5486e-08
CP034451.1|AZO12289.1|5582888_5583296_+|transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	2.24513e-42

Protein sequences

>CP034451.1|AZO12293.1|5586276_5586954_+|TetR/AcrR-family-transcriptional-regulator
MLQPAPEIDNSEALTERQQAVLDAVLRLLVEEGDSLTMTAVARRASCSKETLYKWFGDRDGLLTATVQWQASKVRVAQVDRKGLDLASLTTSLERFASDWLKVISSDTSVALNRVAVGRAGPIKRKEGKDDLGAIVLQNGRFALARRLKPVLEAGRQAGLLHFEDAETAFRTFFGLVARDVQIRLLLGDRLESTEATIGGDAVRATQQFLALFGANNRPQGPGGG
>CP034451.1|AZO12292.1|5585286_5585592_-|Rieske-(2Fe-2S)-protein
MKHEICKIADIPQTGSLVAPFFGREVHVWRSGERIRAAANACLHFGGPLACEDGAFVCQWHGAKFDMENGERINGPAPKGSRLMFLSTRVEDGALNYVWGE
>CP034451.1|AZO12291.1|5584571_5585303_-|glutathione-S-transferase-family-protein
MSGESEMTTKLTLVSHHLCPYVQRAAISLAEKGVPFERVDVDLSNKPDWFRAISPLGKVPLLRVQNSDEVIFESAVILEFLEDTEANPLHPADPLIRARHRAWIEFGSAILNAIGRFYSAADGAAFFAESKALSEMFARVEAELSARQSGPWFAGDRLSLVDAVYGPIFRYFDTFDGIGDFGILAGKLRVQAWRDALSTRQSVKDAVGADYPRRLLAFLRAKGSYLSEIIRLQATEIPQARSA
>CP034451.1|AZO12290.1|5583388_5584618_+|FAD-dependent-monooxygenase
MDKTYDIAIAGAGPAGLAAALYLKRAGHKVTVFERFDEPKPVGSGLILQPTGLTVLADLGLLDEILSLGSRIERLHGTDAKSGRTVLDVRYGARRGGRFGLAVHRAALFGVLYRAAQREAIAIQTKTEIETLEIGEQPRLVCGNGQRLGPFEMVVDASGARSRLRQNLGGAAMPRPLAYGAFWASLGWRNGFDKRALLQRYDKASIMVGVLPIGRPEPDAEEMAAFFWSLKPADVENIQRAGLDAWKARVVSVWPECEVFTRQVENFEQLSLARYGHHTMKLPTGRRMAVIGDAAHSTSPQLGQGANMALLDAAALSQALARTNGIDEALEAYALARRWHVRIFQALSLALTPFYQSDSAALPLVRDRLVAMLAKVPPGPQFLAAMVAGTVIDPFRRIGLAEFRWPAAE
>CP034451.1|AZO12289.1|5582888_5583296_+|transcriptional-regulator
MDSKFVNLKSKIEIYKAMTEGANLADCPVRDVLQGINGKWSSLLVMALAEKPYRFGELRRLVPDISQRMLTQTLYELQRDGYVHRQVFPTKPPSVEYSLTDLGRSMLVPLYQLVQWAELNHDAVREARAAFDARA
>CP034451.1|AZO12288.1|5581858_5582752_-|SDR-family-oxidoreductase
MTETLLVTGASGQLGRGVIRHLLEAQKVTPSRIITTTRDPENLVDLAALGVTVRAADFNDAASLEKAFAGADRVLIISTGELELKSGRRLKQHEAAVAAAKQAGVAHLLYTSMPNPEPGSPVLFSGDHYGTEQAIKASGIPYTIFRNGWYQENLFMALPHALSSGKWYTSAGDGRIAHGSRDDMAAAIAAGLASDSKASQIYTLTGPQAYTTGEIAALVSEVTGKPLEVIQLPDEALTEGVKAAGLPEDLARIIVSFDANTRAGRIDMVTDAVETLSGRKSRTLKEFVEANKAALLG
>CP034451.1|AZO12287.1|5579875_5581792_+|potassium-transporter-Kup
MALANGAEAEPADPSGHPEIEQHSTKVLMLGALGVVYGDIGTSPIYAFREALVASSRGEVADRVDILGVLSLIIWSLTIIVTIKYIMFVLRADNRGEGGVLSLMALARSSFATRSAIILGVGIAGASLFFGDAVITPAISVLSAVEGMNVVTPAFQPYVVPLTLLILAILFAVQRFGTGGVALIFGPITAVWFLAIGLSGLNHIIADPEILWAISPHYIVAFLIHSPDVAFVTIGAIFLAVTGAEALYADLGHFGRKPIVLAWLAIVFPCLLLNYAGQGAFVLAKNGIVGHPFFEMNEGWALIPMVVLATAATVIASQAVISGAYSLTRQAVQLNMLPRLEILHTSEKQSGQVYMPRVNMLLALVVMLLVVGFGESSKLASAYGISVTGNMLVTTVLLFVVMTRIWKWQFWVAASLSALFAFIDIGFFASNIVKVFEGGWASLAVAFAIILGMWTWVRGSRYLFDKTRRNEIPLDLLAANLLKKKPQLVSGTAVFLTSDPLSAPTALMHSLKHYKVLHEQNVILSVVTAPQPVVPDSDRVKMETVNELFMRVTLTFGYMEQPNIPRALAICRKQGWKFDIMTTSFFLSRRSLKASPNSGMPVWQDRLFIGLARTAADATEYFQIPTGRVVEIGTQVAI
>CP034451.1|AZO12286.1|5577812_5579729_+|potassium-transporter-Kup
MVLANASSEAESLERSNHAETERHHSTKVLMLGALGVVYGDIGTSPIYAFREALHASGELVAREDVLGVLSLIVWALTIIVTIKYVAFVLRADNKGEGGTLSLMALARSAYPNGSRLILGIGLCGAALFFGDSIITPAISVLSAVEGLKVVTPALEAYVVPITLLILAVLFAVQRFGTGKVAAVFGPVTAIWFLAIGVAGLYHIVDDFSVFLAINPYYAVSYLATTPTGAFVTVGAVFLAVTGAEALYVDLGHFGRKPIVLAWFSVVFPCLLLNYFGQGAYVLSHGGKPTNPFFQMLPEWALMPMVGLATAATVIASQAVISGAFSLTRQAVQLNLLPRIEVQHTSEMQSGQIYMPRVNLLVALGVMLLVVGFGSSSALASAYGISVTGEMLMTTILLFVVMRWLWKWQLALALALALLFGTIDLGFFSANVVKIVEGGWVSITVACVMGLIMSTWIRGSRYLFDKTRRNEIPLDFLAANLLKKKPQLVSGTAVFLTSDPLSAPTALMHSLKHYKVLHEQNVILSVVTAPQPVVPDSDRVKMETVNELFMRVSLTFGYMEQPNIPRALAICRKQGWKFDIMTTSFFLSRRSLKASPNSGMPVWQDRLFIGLARTAADATEYFQIPTGRVVEIGTQVAI
>CP034451.1|AZO12285.1|5576979_5577720_+|pyridoxine-5'-phosphate-synthase
MPAKLSVNLNAVAMLRNRRDLPWPSVTGLGRIALAAGAHGLTVHPRPDERHTRHSDLPQIRALIDDEFPRAEFNIEGYPTEDFLALVEKHQPEQVTLVPDDPAQATSDHGWNFVAQAAFLTPIVKRLKKGGFRVSLFSDADPAGVTAALNTGADRIELYTGPYGSCHSDSAKAAKELERLGKTADAALAAGLDVNAGHDLTANNLPALAKRIPALAEVSIGHGLTADALEYGMAGTVGRFLKACGW
>CP034451.1|AZO12284.1|5576374_5576776_-|STAS/SEC14-domain-containing-protein
MNFLESVPAIRRIETNRDALFAIDVVGDVSPADAENLFGLLQAAYALHPRVDVLVRLTDQESVDWANISQETLKQGVADALEHVVRCAAVGEPDWASLARGFLPKTLPFEFRRFDAEDEEAAWRWLGARPASQ
>CP034451.1|AZO12295.1|5588432_5588717_-|PilZ-domain-containing-protein
MAENEIRAKHRQRVLKGAAILTGITNSEVKCTVRNMNPGGAELKVPIEARVPDEFLLYVPTDGIGYKAVVRWRREGRIGVAFTGTEPKPHWHYG
>CP034451.1|AZO12296.1|5588888_5589473_-|BA14K-family-protein
MKPLLSSLGSGAISLGLLAGLTVSSLAGPILQPDLSTASSTAAPQIIPVRDDWAGGNNNQQMYDWRWRRGGDFRWRNDGFRARNFSRNWDNGNWDGNWRWRHRHRHRHFDNGSAALLGLGLGLGLGSLAYNNYYDPYYYDPYPRYYQPRRIYRTERLSRAHVRWCYNRYRSYRAWDNTFQPNYGPRRQCISPYI
>CP034451.1|AZO12297.1|5589636_5590749_+|endonuclease
MSLRLATFNVENLMNRFDFSGYRNQLNEDRTLALFDIQSEAEYRALEQARTIAQSDDTRQLTALAIAATRADIICMQEVDNIEALKAFEYGYLFKMIGQGYRQKYTTAGNDTRGIDVAVMMRSETAQGQPIEFVRMTSHAYVTFEQFGLFTQELATLGHLATDRIFRRDCLEIDLTVGGVPLTLYLVHFKSMGSPRNGLDGREATMPLRIAEAQAVRRIIEDRFGKDHAAGKRWAICGDMNDYRQRVKIEGDSFDGYRFHVVDEAQSSINVLTAGGFCENVVERRPEMDRWSFYHTRGPEERHLCQLDYILLSKALAAKNATAVPDIIRNGQPWRTIFPAGQEVERYPRAGWDRPKASDHCPVVITLDMA
>CP034451.1|AZO12298.1|5590751_5591468_+|hypothetical-protein
MSFDLPRNVILPVDEVDVRLDPAPHPFEQGNRAAIAENWRSETSAKPALYDGTVVLLSALGYRDNRLTGRCHAVKYSTFMLWRKNRALSGAEHAYAHAMLVAGDNALVAIRMGSHTVNAGRIYFAAGSFEPIDFRDGLVDVDFNMVREVAEETGLDLSGAERGRRYHALSAPSGTVIFRRYHVPEPAEEIARRINAFIAAEAEPEIEGPVVIRNADNLPDGLMGHMKPLIEWHFAGRD
>CP034451.1|AZO12299.1|5591481_5591712_-|hypothetical-protein
MSKKARVILAAVAVEAMLGGIWWYLARYGLANPDRVAANFQEVVGQTMGMAMGGFLGLCLILFFVAARNDRKAAKS
>CP034451.1|AZO12300.1|5591793_5593011_-|FtsX-like-permease-family-protein
MIWETIRLSLISIRRNVLRSFLTLLGIVIGVAAVIAMLTIGSGTTEKVKADISKLGSNLLVVRSGRPAGPGGPGGLDQITRPLAAKDLAALVAHLSGARAIAPASQKQVRVIFGTESLTSGVTGTDSTYLDARDWKLVSGRPFSDSETRAGAGVCLIGETVRQQFFGAGDPEGEVIRVNRTSCRIIGLLEPKGYTGFGQDQDNVVLMPLAAYQRRIAGNRDIDSIYIAADDRTPTTELQPRVEDILRDTRRITPDRDPDFSIRDMTQIADAMASATTTMTGMLGAVAGVSLLVGGIGIMNIMLVSVTERTREIGIRLAIGAHEKHILIQFLVEATVLSLLGGIIGILIGLTLAGLAAATLTIPFAPSPAVILLAVGFSALIGMVFGFFPALRGARLDPIEALRHE
>CP034451.1|AZO12301.1|5593007_5593712_-|ABC-transporter-ATP-binding-protein
MSAPLLITFEKVWKSYGEGEARVHALAGVDLAIRRGEFVAIMGPSGSGKSTAMNIIGCLDTPTAGTYSFMGIDAGRLDRNRRALLRNLYVGFVFQGYNLLPRTTAAENVELPLIYRGVAARERRQLAMRALAEVGLTGREHHTPAELSGGQQQRVAIARAIVTRPTLLVADEPTGNLDSARTHEIMELLTRLNAELGLTIAMVTHEADVAAYAERTVRFLDGHVASDTVNAEAA
>CP034451.1|AZO12302.1|5593716_5595006_-|efflux-RND-transporter-periplasmic-adaptor-subunit
MDQLVNPPKAESDPSIEAALGLDRKGMNRKRRRGWLFAVLTLALVAAGIGGYQWYAASPPRIEYTTVPAAIADLTVAVSATGTLQPLTQVDISSELSGVVRSVAVNENQQVKKGDVLATLDTAKLEVQIERATASAKAATAAIENAKVTLQEDENALTRASELTKRGMATDQSLEAATATRDRSKAALDSAEANLAIAQADLKAQQTDLAKSTIYAPIDGIVLTRSVDPGQTVASSLQAPVLFVIAADLRNMELQAAVDEADIGTVKPGQHARFTVDAFPDRPFDAEIRDISYASVTTDGVVTYNARLEVDNSELLLRPGMTATVSVVTRQAKGVLTVPATAFRYRPAQQMARGWSLRDLFTGRMGRPNWRQREVTKAPTDGSRTLYVLENGRPRPVNVRIGSTDGELTEITSGLDEGAEIITGSQQRS
>CP034451.1|AZO12303.1|5595141_5596044_+|PhzF-family-phenazine-biosynthesis-protein
MARNYLLYDVFTTEKLAGNPVAVVLDCEGLDTAAMQAIAREFNLSETVFVLPPDNPKHRNRIRIFTPDYEMPFAGHPTVGTAIALAELAGEAAGIFVLEENIGPVRCAVSKHDGSTFAEFDLAKLPEQLELKADPEAIGAALGLAPHELGFENHRVSFWSAGVPYVMIPVAGLEEAARARLDNQAWSELAPRKSEWAFASPYIYCRETLHHDSAFHVRMIVPGNPSYEDPATGSAAAAFAGAIMHFDGPTDGISQLWIEQGLEMGRPSRIRLELNVDGGKLASARIGGHAVKVAEGKLTL
>CP034451.1|AZO12304.1|5596349_5597360_-|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase
MSFKSLEDLRAACLDLPAGSDAAASAVAGRQDTLTKPQGSLGRLESIAAWLGRWQGRDMPKLDEVKVFVFAGNHGVTAQGVSAYPSEVTVQMVANFAGGGAAINQLARIAGAKLDVIPLDLDHPTGDFTQVPAMDEQAFLAAVSAGYDAVSKDLDLVCFGEMGIGNTTPAAAISAALFGGGAEKWTGRGTGVDDAGLIRKITAIDAGLARHAGSLSDPLKIAAALGGRELAAIFGATLAARHNNVPVLLDGFVCTAAVAPLARLHPTGLAHTIAAHVSAESGHRRLLEALGLPPLLDLGMRLGEGSGACLAVNLVRSALECHARMASFAEAGVSEK

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_HG938356	Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence	521819-521847	6	0.793
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP018229	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence	648818-648846	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP016287	Rhizobium leguminosarum strain Vaf10 plasmid unnamed1, complete sequence	643906-643934	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	2199401-2199429	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP053441	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence	27770-27798	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP030761	Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed1, complete sequence	237287-237315	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP050092	Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence	77382-77410	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP050099	Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence	27775-27803	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP050104	Rhizobium leguminosarum bv. trifolii strain 4B plasmid pRL4b2, complete sequence	345022-345050	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP025014	Rhizobium leguminosarum strain Norway plasmid pRLN2, complete sequence	27333-27361	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP025507	Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvA, complete sequence	47797-47825	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP050109	Rhizobium leguminosarum bv. trifolii strain 3B plasmid pRL3b2, complete sequence	345022-345050	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP022666	Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR1, complete sequence	761917-761945	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP050086	Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b7, complete sequence	359047-359075	7	0.759
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP018229	Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence	687086-687114	8	0.724
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP053441	Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence	250640-250668	8	0.724
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP021071	Mesorhizobium sp. WSM1497 plasmid pWSM1497, complete sequence	176908-176936	8	0.724
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP015065	Mesorhizobium ciceri biovar biserrulae strain WSM1284 plasmid pMc1284, complete sequence	206961-206989	8	0.724
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP015063	Mesorhizobium ciceri strain CC1192 plasmid pMc1192, complete sequence	224947-224975	8	0.724
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NZ_CP022566	Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK02, complete sequence	272095-272123	8	0.724
CP034451_4	4.1|2469883|29|CP034451|CRISPRCasFinder	2469883-2469911	29	NC_014918	Mesorhizobium ciceri biovar biserrulae WSM1271 plasmid pMESCI01, complete sequence	313199-313227	8	0.724

1. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_HG938356 (Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141 plasmid pHAMBI1141a, complete sequence) position: , mismatch: 6, identity: 0.793

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
acacttttgcgcgacatgctttggtttaa	Protospacer
.****************** * ***.*  

2. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP018229 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
acacttttgcgcgacatgcttagctggcc	Protospacer
.****************** *** *  ..

3. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP016287 (Rhizobium leguminosarum strain Vaf10 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
acacttttgcgcgacatgcttagcaatgc	Protospacer
.****************** ***   * .

4. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgcgcgacatgctttggagccg	Protospacer
******************* * **  .. 

5. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP053441 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcat-----aggtcttt	CRISPR spacer
acacttttgggcgacatgcattggggagg-----	Protospacer
.******** ***********     ***     

6. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP030761 (Rhizobium leguminosarum strain ATCC 14479 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattagttgaa	Protospacer
********* *********** .**.   

7. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP050092 (Rhizobium leguminosarum bv. trifolii strain 22B plasmid pRL22b6, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattagttgaa	Protospacer
********* *********** .**.   

8. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP050099 (Rhizobium leguminosarum bv. trifolii strain 9B plasmid pRL9b5, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcat-----aggtcttt	CRISPR spacer
acacttttgggcgacatgcattggggagg-----	Protospacer
.******** ***********     ***     

9. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP050104 (Rhizobium leguminosarum bv. trifolii strain 4B plasmid pRL4b2, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattagttgaa	Protospacer
********* *********** .**.   

10. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP025014 (Rhizobium leguminosarum strain Norway plasmid pRLN2, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcat-----aggtcttt	CRISPR spacer
acacttttgggcgacatgcattggggagg-----	Protospacer
.******** ***********     ***     

11. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP025507 (Rhizobium leguminosarum bv. viciae strain UPM791 plasmid pRlvA, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattagttgaa	Protospacer
********* *********** .**.   

12. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP050109 (Rhizobium leguminosarum bv. trifolii strain 3B plasmid pRL3b2, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattagttgaa	Protospacer
********* *********** .**.   

13. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP022666 (Rhizobium leguminosarum bv. viciae strain BIHB 1217 plasmid pPR1, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattagttgaa	Protospacer
********* *********** .**.   

14. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP050086 (Rhizobium leguminosarum bv. trifolii strain 23B plasmid pRL23b7, complete sequence) position: , mismatch: 7, identity: 0.759

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattagttgaa	Protospacer
********* *********** .**.   

15. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP018229 (Rhizobium leguminosarum strain Vaf-108 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.724

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
acacttttgcgcgacatgcttagccgacg	Protospacer
.****************** *** .  . 

16. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP053441 (Rhizobium leguminosarum bv. trifolii strain CC275e plasmid pRltCC275eE, complete sequence) position: , mismatch: 8, identity: 0.724

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
acacttttgcgcgacatgcttaaagcggc	Protospacer
.****************** **.. *  .

17. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP021071 (Mesorhizobium sp. WSM1497 plasmid pWSM1497, complete sequence) position: , mismatch: 8, identity: 0.724

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattaaccagc	Protospacer
********* *********** ...*  .

18. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP015065 (Mesorhizobium ciceri biovar biserrulae strain WSM1284 plasmid pMc1284, complete sequence) position: , mismatch: 8, identity: 0.724

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattaaccagc	Protospacer
********* *********** ...*  .

19. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP015063 (Mesorhizobium ciceri strain CC1192 plasmid pMc1192, complete sequence) position: , mismatch: 8, identity: 0.724

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattaaccagc	Protospacer
********* *********** ...*  .

20. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NZ_CP022566 (Rhizobium leguminosarum bv. viciae strain BIHB 1148 plasmid pSK02, complete sequence) position: , mismatch: 8, identity: 0.724

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
acacttttgggcgacatgcatggggagga	Protospacer
.******** ***********.**     

21. spacer 4.1|2469883|29|CP034451|CRISPRCasFinder matches to NC_014918 (Mesorhizobium ciceri biovar biserrulae WSM1271 plasmid pMESCI01, complete sequence) position: , mismatch: 8, identity: 0.724

gcacttttgcgcgacatgcataggtcttt	CRISPR spacer
gcacttttgggcgacatgcattaaccagc	Protospacer
********* *********** ...*  .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	3841035 : 3930624	58	Stx2-converting_phage(25.0%)	transposase	NA
DBSCAN-SWA_2	5814299 : 5822590	9	uncultured_Mediterranean_phage(85.71%)	tRNA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>CP034451|3841035:3930624|DBSCAN-SWA
GATGTCGATGCCGGGAGTCGGTCCGATCGTGCCGCTCACTTATGCCGCTGCCATCGACGACCTCGGGCGCTTTCGCTCGTCGAAGCGGGTGGGCGCGCATTTCGGCCTGACTGCGAAGAGGTATCAATCCGGCGAGACCGACTACACTGCCGCATCAGCAAGATAGGATGCCGCAGTGCGCACGGCGCACTACGATCACATCATGCTGGTGAAGCCCGTCAGGGCTGCACGGAGCTGAAAAGCTGAGCGATGCGGATCGCCCGGCGGGCCGTGATGAAGAAGGCCAAGGTGGCGCTGGCGCGCAAGCTTGCGGTGATCCTGCACCGCAAGCTTGCCGATGGAACTGTCTTCAACGAGGCGGCCACGACGGTGACCGCAGCCGCCTGAGAAATTCGGGCGGGTTCACGACACCAGGACCTCCCGAAGCGAGGTCCCTTTGCCGGGACGATGGCTCAGGTCAGACCGCAACAGCCTTCGTGGCATCTCGATCACACGTCACTAGACTGGTCCGCCTTATCCTCTTCAAACCATCAGGTGGCGGTCGCGCACCGACCCCGTACAGAAGCAAGACCCAGCAACTGGACGACGCAAAAAGGGGTTGACCTGTCGAGGCCCGTACAGAAGGGGCTGTTACGATTCGGCAAATGTGGCAGGGTGGCGAATCACTTGCTGTGGCGAGGCATTGCCACGGCATGTTTGCCGGCCACAACATAGCAAGCGCTGCGGAAAAAACGACGTTGAGCCAAGATTCTGTCGTATGTTAGAGTAAGTGGTATGAACAAGCTAGACCGAATGGACTACCGATTCTGGATGTGCTCCAAGAAAACGGCCGACTCCCAATAAAGGTCCTTGCCGACAGGGTCGGCATTTCCGTTTCGCCGTGTTGGCAGAGGGTAAAAAAACTCGAAAAAGATGGAATTATCCGTCGTTACATCGCGGAAATAGCGATCGAAAAATTACAAAGTATTCAGGGTGTTTTGTCTAAAGTAGTCCTGTCAAGACAAAATCGAGACGCATTGGAGTTTTTCGAACGTCACGTGTGTGCCATTCCCGAAGTCGCAGAGTGTTATGAAGTAGTGGGGCATTTTGACTACCATATCAAATTTGTTGTTTCTTCAATTGACCGTTATACCGAGATCGTAGAAAGATTTCTGACCCCTGGATTTGGCGTTGAAAGGTATTTTACCGACATAGTGAGTCGGGTTGCCAAAGAGGATCGGGCTATCCAACTGCGCCGTTTTGGATAATCAATGTGCTGTAGTTTCGATCGCCCTTGCCGCTTCATCGAAGCGTTGCTTTGGATTGTGCGGACAGGAAGTCCGTAGCGCGACCTTCCAGCCTTCTTCGGGAGCTGGAACACCGTTTTCAAGCGCTACCGCGACTGGGTCAGAGCTGATGTCTTCATTCGGCTTTACGAGGCCTGTTCGGATGAACCGGGCATGGAACACGCCATGGTTGATGCCACCATCGTCAAGGTCACCGCCATGGACAGGGCGCAAAAGGGGGACTCAAAGCCACGCCATAGGCCGCTCCAACATGACAACCAAAATCCTGGCACTCTCCGATGCACTTGGCAATCTTGTGCGCTTTGTTCTTTTGCCCGGCCAACGGTTCGACACCGTGGGTGTCGCACCGCTCATCGATGGTGTCTGTTTCGGCGGCTTGGGCCGACAAAGCCTTCGACAGCAACACCATCATTGCCTTGAATGAGCGCGGCGCCAAGATCATTATTTCACAGCATTCACGTCGTACTTTTCCCCTGCCGCTCGACAAGGCACTCTACTAGTGGCGCCACTTGATTGAGAACTTCTTCGCCAAACTCAAGGAATTCAAGCGTATTGCTATGCGAGCCTACAAAACCGACCAGAGCTTCGCAGCCTTCATCAATCTCGCAGCCGCCGTCATAAACTCACGCTGACGCTCAACAAGCCTTAGTTTCCGTCCACAGTGTGCTGCAGCAAGCAGAAGGAGGTTCGATGGTGAACTGACAACATGCTGAGAAGCTGCGTAAAAGATGAAGGTAGGCCCCTCGGGATCGGCTTTCAGGAGCGGGTCTCAGGCCAGCCCAAGCTGCTGTGGTAGAAGAGCCATGATGTTTGATGACTGGGCAGACAGTGGACGCGTATTGGGGGCATGAGCCGGATGCAGGCTTTTGGGCGGAACTGCAGGAACCAGCTTCCTGATGCCAAGGGAGAAGCACAGGCGGCAAACCACCGTGAGGCGAGAGTACCGATGCAGGAAGCTGGGACGGACCGACCCGTAGTAGTGACGAAGGTCCCGTAAGTGGGCTGGAGCGAAGGAGTCGGTTCAGGTGGTCGTATTTTTCGGAACAACTGGAAACAGGATGACGACGGCGACCATGACAGACAAGCCGTTTAGCGGCTGGCCTACAAAGCGTTCAGATCCTCGAAAGGCGGAGCTGGAGTGGATGGGCAGACAATCGAGGCATTCGAAGCCGATCTGGAGGGGAACATCTACAAGATCAAGATTTCAGGATCACACGCTCAGGCACACGTATTTCATCTCTGTATAATCATCGATTCCGTATTTTGACCCTTCGCGGCCAAGGCCAGATTGCTTGATGCCACCAAAAGGCGCAACTTCCGTGGAGATCAGCCCAGTGTTAACCCCGACCATGCCGCACTCGAGAGCCTCCGCCACCCGGAAGATCTTCGAGATATCTCTGGAATAGAAGTATGAAGCGAGGCCAAACTTGGTGTTGTTCGCCATTTCTATCACTTGTTCCTCGGTCGAAAACTTGAACAGCGGCGCGATAGGGCCGAACGTCTCTTCCCTCGAGAGGCGCATATCCCCCGTTGCGCCGGTCAAGATAGTGGGCTCGAAAAAGAGGCCGCCTTGGCTCGCAGGCTTGCCACCGACCTCCACTGTAGCCCCCTTGGCGATGGCGTCAGTGACGTGCTCCTGTACCTTCTTCAGCGCATTCCGGTCGATGAGAGGGCCTGTCGTGACCCCTTCGGCAAAGCCGTCGCCGACTTTCATCTGGCGAACGCGCTCGGCAAGCTTGGCGGCAAAGGCATCATAGACGCCCTCCTGAATATAGAGCCGATTGGCACAGACGCAGGTTTGCCCAGCATTGCGGTATTTGGAAACCATTGCGCCGTCGGCGGCGGCGTCGAGATCCGCGTCATCGAAAACGATGAAGGGCGCGTTACCTCCGAGCTCGAGGCCGAGCTTTAAGATCTGCTCTGCGCCTTGCCGCATCAGTATTTTTCCGACATTGGTCGAGCCCGTGAACGTGACTTTCCGAATCTTCTCATTGCGGCAGAATTCCTGACCGACCATCGCGGCATCGGTCGTGGTTAGCACAGAAAAAAGACCGAGTGGCAGGCCGGCGCGTTCGGCAAGGACAGCCAGAGCGAGCGCGGATAGGGGCGTCTGAGCCGCAGGCTTTGATACCATGCTGCAGCCGGCAGCGATTGCCGGGGCCATCTTGCGGGCAAGCATTGCATTCGGGAAGTTCCACGGCGTGATGGCCCCAACAACTCCGATGGGCTGCTTGATCACGATGATGCGCTTATCCGGCTGATGACCTGGAATGGTGTCGCCGTAGACTCGCTTTGCTTCCTCACCGAACCACTCGACGTAGGATGCACCATAAAGAATCTCTCCCTTCGCCTCCGTCCATGGTTTCCCCATCTCTAGGGTGAGGATAGTGGCAAGATCATCGACATTCGATACTATGAGGTCGTACAGTTTTCGCAGGACTGCGGCGCGCTCCTTACCCGTCCTTTTCGCCCAGTTCTTTTGGGCAACATAGGCCGCCTCAATCGCCGACTTGACCTCCTCTTCACCGAGATCTGGAAGGGTTGCAAGGACTTCGCCGGTTGAGGGATTGGTGACCTCGAACGTGAGGCCCCTTGAACCTGCCGCTACCCACCCAGCCCCTACGAGAGCTTTATCCGTCACTAACGACTTGTCTTTTAACTTCGCTAGCACTGCTTCAGAAAGTGACATTTAATTTCTCCCGTATTGGTGCGAGCCCAAGAGCCGCCGTATATTCCACCAGAGATAGAACTTTGCGCTCTAGCGGGCATTGTCTTGTTCAAGGATGGGCCGATCGCAGAAACGAAGAAATCGATCGCCACAGAACAGACTCCCTCTCTAGGAGGCCGGCTGACTGCCACACCGCGTCTAAGTCTGCCAGCGGTGAGGATTATCCCACCAACATCGGCGTGCGGCCTTTCAAGTACCCAGTCGGCTTCTCCATATTGAAATCGACCGTATAAACTTATGCTAATTATCCCCGGTTAGTCTAAGAATTCGTCGGAATAGACAACGGCTGGCGTAGGAACTCTGAACCCTTCACGCCGTACAACTTCAACGACCTTCTCAAGGTCATTCACCAGCAAGGTTATATATTCATCTCGCAGTGGTCCAAGTACAAATTGTATTGCCTCTGGCTCCTTTAGTATATTTATCTTCCACCCGTACTCCTTCATCCGGCTTGCAATTGAATAGATGTCAGAGTATTCGCTCCGTATTCCCACCACGTTAAGCTCAGCTCCGCCGACTATCTTCAAGCCGGGGCACTGTGCAACGAAGGCCAATATGGCATCTCTCAGCTTGAGGATTTGAGCAGCGCGAGAGAGGTAACCGTCCCGCCCCAGATAACGCATGACTGCCCAGGCCGAAGCGATTGCGCCTCCGCTTCGTGTTCCAGTGAGAACTGGTGAACGATAAAGTCCTGCTGCCCATGTGTCGAAAATGAAGGGTTGATGGCGGGCTACCTTATTTTTATAGAAAACGCCCGACACTCCCTTGCCACTATAGCCGTACTTGTGAAAATCCGCCGAAATTGAGCTTACACCAGAGAGTCGAAAATCGAAGTCCGGAACGTCCCGTCCGAGCTCCCGCACAAAAGGCGCCAAAAACCCGCCAACGCAAGCATCCACATGCAACCAGATCCCGTGTTGGCTGGCAATTTCTGCTAATTCTCGAACTGGGTCACAAACGCCATGCGACCAGGACGGCATTGAGGCGAGCATCATGACTGTGTTTTCGCTAACTGCTTCAGACATTGCCGAGACGATTGCGCGAAAATTTTCATCCACTGGAACGCGACGGATAGTATATCCGAAATACCTTGGCACGCCGGTGCTCACGCGACACCGCACGCTGGCAGGGTGGATGGCATAGACCTCGATGTCGCGCGCCCGCAGCCAGCGCGCCAGCCAAAAGCCGTCGCCGGCCGCCTCATAGGCGACGGCGATCCGCTTGATTGTATGCCCGGCCTGGCCGGCTTCGTCGCGCAGCTTCAACAATGATGGCGCGTCGGCATCAATCTTCTTCAGCGGCTCATGGGGCGCCTCCTTCTGAAGAGTTGGTTCTAACAGCGCCGAAAGATGCCACACCCTCGCCGCTCGCCCATAGCATCTACGCCCCGGGACACGATCAAGGTGGGAATTATCCGTCGCGTCACTGCAGAGAAAGATATTGAGCTTCTGGCTTAGCGATGAGCAGTTTTCGATTGGGCTTGAACGCATCCGAGGCAAGGATGCGCGCTCATGATCGCTGCGTGATCAGTGGTATCGTTCGTGCGGTAGGCGGCGGACGCTGGGCGACGCTCCGTCGGTCTGTGAACCGCGCAAGAAGATCGGCGCGGGGACCGGCTATCCCATTGGCCCCCAGTCTCTTGCTCCGTTGCTTCAGCGGCTGTCCTGACCATAGAGATTGGCCCGCCGGATGGACCTAAAAGAACAGCCGGCGGAAAATAATTCCGGCCAACCCGTAAATCTGGCCGCGGCAAAGATCAGTGATCAAGTGGCGCAACGGTCAAACCGATCAGACGGTTAAGCCCTTTATTGTCCAATCGATCGAATGACAGCGCTATCGCTTCCATCTCCTCGGCCCTGCCATCGCTGATCAAACCGTTCGTGAAATTGACGTATTTGCTGTGGAACTCTTCCGCGCTCATGGGATTGTCGCGATCGCCTTTCGGCGTGCGCGGCTCCGACATGATTTGGCGGCCGTCCTTTAGGTAAAGCGTGACGTCGGCCCAACGCTTACCGACGCTGATGCGGGTGTAGTGCTCGGTTTCAACAAGCTCGGTGGCGTTGGAAATGCGTCGGATTTCTTCATCTTGCAGAACCTCCGGCAAAAGCTCCTGCGGCCCTATTTTGCCACGCACGATCATCGTCGCAACCGGGAACGCGATCGAATAGCTCATTTCGTCCAGCGTCTTCGGGTTGTGACCAGCAAGCCGAACGGCATTGTGAAACGTCTGAATCCGGACACGCGTCACATCGTTGCTGGAAAGGCAGTTGTCATGCATCAAGTCGCGCGCGGCATCGATCGATGGATGCGCCCAGCGACAGACCGGATAGGGTTTGTATGAGGTATCTTCAGCGACACGCCAAGCCTCTCCGAGATCGCACCACCACGGCTCGGCGCTGGCCCCCTCGGCCGTGATCGCCGGCGCGCCAGTGAAGCCGAGGTCAGCCAAATAGGCTGCCATGACGCCCGACGGCGCACCCCAGCCGACGCCGTCGCGCAGCATGGTTGGAAAATCGATGCAACGCATCATTTGGCTGCGAGGACCGTGGTATTCTGCAATGCCCGCTGCATGGCGCGTCTGCTCCTGGCTGAGCCCCAGCAGTCGGGAGACTCCCGCCGCCACGCCGACCGCTGTCCACGCCCCTGAAGTGTGGTAGTCGGAGACGGTGCCGTGAAGCGTCAGACCCGCGCGGTAGGCAACCTCATAAGCAACGGCCAGCGCAACCATGAATTCCCTTCCAGAAATTGCGGCGCCCGAAGACCTAAGCGAATCCGCTACAGCGAGCAGCGCAGGAAACACCGCCGAGCCGGCGTGGCCCTTGCAGGGGCTGTTGTTGTCGTGCCCATCGATCGAATCAATGGTAAAAGCGCCGGCGAATGCCGCTCCCGCCGGGCTGACGGGGCGCCCGTCGAAAATCATCCTGGCCGCGCCGATTTCAGGCGACGACCGCCATAGGCGATCGGCAATCTCCCTAGTGATCGACGAGATCTGCGTGGTTGCCCCCACCACCGCGACGCCGAGCGTGTCTGCAAAACTGCGCCTGAGAATGGCACGGACCTCCTCGGGAATGGCATCGTAGGTCAGGCTAGCGGCAAATTCGGAAAAGGTAATCATGTTAAACCTCGCACAATCTCTGATGCGGCCTTCAACGGGCCAATTCCCAAGATGATAATATTTTCCAGGGACACCTCCATCCTAGATAGCTTCGACACCGCATAACTTGGCAAATTCCGATGCCGTTAGAAGGCGGCTTCACCATCGGGCGACGTGCCGGATCCGCTTGTCGATTAGCCCCGCGCGGGCTTACGGTGCGGAGGCGTCTTCGATTGGGCTGCCCCGCGGCTAACCTCGGCGCCGATGTACGAACAACACGCGGATCAAGGTTACGGCCCTGACTTCGACACTTCTTCGTCCGGCGCCGACGCGAGGTTGCAATCAAAGCAGAATCGCCACGTCCCATTCGACATTTTCCTTCTGAATCATGTGGATCCAGAACCGTCGAGACCGGCCTTACAGATGACGAGATAGGAAAGCATCGTCTAATTCGCGACCGCGCTTTATTCCTGATCTGCGAAAACCGCGTCGGCAGCCCAGCGGCATCGCCGCCATAGACCATGCGCTTAGACATCGTCGTCGGTTGGCCCAGAGACAGAACGTGATCAGTCGGGTCGACTGGCTCAACTCCATCGAAACGAAACATGCCCATGACTAGGGCTCCGCGCTTCCGATTCAATGTCCTCTCTCATCGCATTTTCTCCAGGGGACGTCATGATTCGAGTTCTGTCGGCTCTGCACCGAGTTGAAACAGAGAAACCGCATATTGCTGGCGCGAGTCCGTCCAATGCTGAACCGGGCGGAAATTATACAGACCGAGCAGCTTGTGGAACGCACACAATTCAACCTTCCGCATGATCTCCGTCCTAATCATCTCTCCCTTCTCGAGATGAAAGGAGAAATTCAGACTTTTTAGATTGATCATTTGTTCCTGCATTGCTTCCAGATAGCTCTCCATTCGATACAGCGATTTATTATGGAATGCCACGTGCCGGAACTGGAATGGATCAAAATCTCCACCGAAACGCCAGTTCAAATGTTGCAGGACACATAAGTTGGTCAGAATAGCTGTTTGATTATTGTAGGCCGCCTCTAGAATTTTGGTTTCTTTGTCCAAATCCATCCCGACCAAAAGATAGTCGCCAGAAGACAAAGCCGATCGCGCCGATAGGAGGAGATCATGCAGTTCGTCATCGTGCATGTTCCCCATAGTGCTGCCGAGGCAAACTAAAAGCTTTGGTCCAATTAGATTGGCGACTTGCGCGAGTCCGGTCTGGTAGGTCCCGACAATTCCTAAGAAGTCCAAATCGTCTGTCACGGAGAGAACGTTCTCAGCCGCCCTCTCCAAGATCGAGCGATTAATGTCGATGGCAGCGTAAAAAGTGCGGCCGTGTTCCTTCAAGTAGGCATCAAATAAAAGAGTCGTTTTCTCGGCGTTTCCAGATCCCAGTTCAACGATAAAGATAGGACCTGTGATGTCGGCTATGGACCTTGCATGTTCGGCTAGTATGTCCTTTTCTGTTCTGAACAGGTAATATGTTTCCTCGTGACAGAGACGTTCAAATAGGCGAGAACCTGCATCATCGTAGTAATAAATGGAGTTCACGCTGCGCGGTGATTCCGATAACGACGCCACCAATAAGTCGCCCTTGAATAGCGTTTCTTCGGGTATGTCCGCGCCGAGGATCTCATATTTATTGCGTGTAGCCACTGCGGTTGTCCCGGGACGATGTCGAGCCATACAGATACCTCCATTCAAGAACGGTGTACTGGGGACGCGCAAAAGCCGTGCCAGTTTCGCCGATGAGAGCGTTGGAAAGTCTTTTTCCGAATGTTGTTCAATGACTTAAATGGGGTGCAGTGGAGCAAAAAGCCGTTACATTGTGTGGGGGAGCCGACAGACCCGACAGCAGGGTGTCGGATACCGGCATTGGATCAAGTGTTGGAAGAATGGGCGGCCATGAAGCTGCTGATGAGGCAACCTCGCGATTGCGCTGAATCAGTATGAGGTCATTGGCGTGGTCCCGCGCCACCGTGACGACCGCCCGGGCTTGCCACGAAGGCCGGCATGAGACCTGCTGCGTTGCCGGTGGCCTGGAGCTCCAGACGGGCTACAGGAAGATACGTCACAGACACCTCGGTCAAGATGCGTCCAGAGCGTCGATTGATGATGAGCATTTCGTGAGTGCGTGTTTCGGTCCAGATTCTTTCGGGGCGAAGGGGGATTTGCCTATGGGACCAGCAGTTCAGTTGCCGACAGACAATTCGGCTTCGGAGCTTCGCCGGTTGGCACGGGCTTCGAAGGACGCGCGGCAGAGCAGCCGTTTGCTTTCGCTAGAGCCTTTCAGGTTTTGACGGAAGCATATCCGGCATTGAAGAAGTAATTGCTGCATTCGCCGGGCTGGATTGAGGAGACGAGGCAGCCGACGTGTTGCCATGTCTCCTCGATGGTTCCCTTCTGAGCCACGCGCATCCAGTGCTTGATCTTGGCGAAGGCCTGCTCGATCGGGTTGAGGTCGGGCGAGTATGGCGGCAGATACCAGAGCCTTGCGCCGGCGGCTCGGATCATCTGCCGGACGGCGGCCGACTTGTGGGAGCCAAGATTGTCCATGATGACGATGTCGCCGGGCTCGAGCACAGGCAAGAGCTGTTGCTCGACATAGGCGCGGAAGCACTGACCGTTGATCGGTCCGTCGAAGACGCAAGGCGCCGTCAGCCGGTCGTGGCGCAAAGCGCCGAGAAAAGTCAGCGTGCGCCAGTGGCCGTGCGGGGCAAAGCCGCGCAGGCGCTTGCCTCGTGGTCCCCAGCCCCGCAGCGGCGCCATGTTGGTCTTGATCCACGTTTCGTCAATGAACACCAGCCGTCTCGGATCGAGACCGGACTGCCAGGATCGCCAGCGTTGCCGCCGGCGGGCAATATCAGCACGGGCCTGCTCAAGGGCGAACAGTGTTTTTTTTGAACCGCAGCCCCTCGCGCGCAGGAACCGCCACACCGTATCGTGCGATACCTTCACCCCGCGCGCCGCCAGCTCATCCTTCAACCTGTGCAGCGACAGATGCGGTGTCTGGTTGATCCGCTCCGCGATGAAGGCACGGTGCGGCTCCAGCACGCGCTTGCGATGACCGCCCACCTTGCCGGGCGCGACAGACCCGCTCGAACGGTAGCGCTGAGACCACTACACCGCCGACGATACGGCAATGCCGAAACGAGCTGCGACCGATCGGCAGCTTTCGCCCGCCTCGATCGCACCAACAACACGCTCACGAAGATCATTCGAAAGAGGTCGCGTCATCCGATGCTGGCCTCCACTCCAGCCAGCATCTTGATGGGGTGGACGGCCCCCGACCCAGCGGCATCGCAATGTGCCAAGATGGCGTTGTCAAAGGACCATCAGAGGGAAGGAACCGTCCGCATGCAAGTTATCACGATCGGATTGGATATCGCCAAGAACGTCTTTCAAGTTCACGGCGTCGATAATGCAGGAAACGCGGTGCTCCGTCGAAAAGTTCGGCGCGATCAGCTTATTCCGTTGCTTCGCGATATGCAGCCGTGCCTCATCGGCATGGAGGCCTGCGCGACGGCGCACCATTGGGCGCGGGAGCTGATTGCACTCGGGCATGTGGTCAAGTTGATGCCGCCGGCTTACGTAAAGGCCTACGTCAAGCGCAACAAGAACGATGCGGCCGACGCGGAAGCGATCTGCGAGGCGGTGACGCGACCGACAATGCGGTTCGTGGCTGTCAAATCGGCGGATGCCCAGAGCATTCTGATGCTTCATCGGGCTCGCCACCTCTTGGTTCGGCAGCGCACAGCGCAAATCAGCGCGATGCGGGCGCATCTGGCCGAGTATGGCGTCGTCGCACCGAAGGGCCGGGCCCATGTCCGTGGTCTAATCGAAGCTCTTGACAAGGGCGATGGGCCGCTCCCCGCGATGGCGCGACAGGTTCTTATCCTCCTCGCCCGAACGATCGAAGGGCTTGGCGCACAAATCCGGAAGATCGAGATCGAGCTTCTGGCGTGGTATCGCACGAACCAGGTCTGCCGGCGGCTTTCAACCATTCCCGGAATCGGCTTCATCACGGCGACCGCCCTCGCTGCCACCGTCGTCGACGCAAAAGTCTTCCGCTCCGGTCGTCAATTCGCTGCTTGGCTCGGCCTTGTTCCAAAACAACATTCCTCCGGTGGCAAAGACAGAATGGGAGGAATCTCGAAGATGGGAGATCGCTATTTACGGCATCTCCTCGTCGTCGGCGCCACGGCGGTCATCCGATACACGCGGCGAAAAGCGACGACCGTCAGTACCTGGGCGAACCAGTTGCTCGAGCGTAAGCCGGCACGGCTGGTCACAGTCGCTGTCGCCAACAAGGTAGCGCGGATCGCCTGGGCGGTGATGGCGCGTGAGGAAAACTACCGCGCGACGCCGTCAATGGCTCGAGGGTAACGACGGTCGCGCGAAATGACATCCAGTTTGGGCAGGAGAGAACGACATCAGTGATGCAGATCCGGTCAAGCCGGGGATCGGGAGAACCTGAGTGATTCAACGCGCATCGCAGCGCGGCAGCTTGATGAGGGCCCGATCCACCGACACCATCATGGCCAGCGGCCTGAGGCCGCACAAAAACAGGCCGAACACATGAATGAACCTGACCGCTTCAGTATTGCCATTGTCAGAATCTTCTTGCTCAACGGGGGCCGTCCACACATGAATCACAAAACAGCCTAAACCGGAATCCCCTCAGATTCAGTCAAAACCTGAACTGCTCTAGCGGCGGGGCTTGACGGCATGAGCCGTGCGGACGCGGCAGGATCGGCGGGATGGACCGCCAGACCTTGCGGGACTGGGCACACCGGTTCAACGAAGCCGGGCCGGATGGGCTTCTGGATTCGTGGTCGGATGGCCCACATCACGGCTTTTGCCCAAGCAACCGGCAGAGCTGGCCGAGATTGTCGAAACGGGCCTGATCCTGCCGTTGACGGCGTGGTGCGGTGGCGCCGCGTCGATCTCCAGCGGGTCATCAAGGAGCGCTTCGGCGTCGAGTGCTGAAGAGGCTGGGCTTCTCGCACATGAGCGCCCGGCCGCGTCACCCCGCGCAGGATGCCGACACCGTCGAAGGGTGTAAAAAAAATTCCCGCGCACACTGAAGGCCCATCTGGTGGACCTGCCGAAAGGCACACGGGGGGATGGTTTCAAGACAAAGCCCGCATCGGCCATAAGAACGGCTTGGTCCGTCAATGGGCAAGACGTGGCAGGCGTCCCCGACAGCACGTGCCGGAGAACATCACGCCGATCTTCCTGCCGTCGCGATCCCCCGAACTGAGCCCGGTGGAAAACCTCTGGCAATACCTGAGATCCAACTGGCTCTCAAACCGAGTCTTCGCTACGACGCATCATCGACGCGGCGTGCGAGGCCTGGCAGAAACTCCTCGCCAATCCAGAAACCATCACGTCAATTGGAAAGAGGCGGTGGGCGCATGCCGTCGGTTAATCGTCATGACCCCTGGTATCGTGTCCGATCGCCCGATGCGCACCTCGTTGTACAATCCTGTTTCATAACACCCATCTGTCTATGCTGCTGAAGAGAATGTGGGGTGTTTGGGTTCTGCCTCGCACGCAAAACAATGCTCTGAGCCACCGGTTCGCCGCGCGTTGATCGGTTGAAGATCCACAGGCCATCCGGTAGGGGATGAATACCTTCGATCGCGCCTACTTCGGCGGCGAGCCTGAGCGTCTTCGGTGCAAGCCGAGCAAACGCGCCGGCTTGTTCGTTCCGGTTCAGGATGCCGGTAATCAGGTCATCATTGGCTATGAGAACCAGTTGCCGGAAGGTTGCCAGGATGTCGGCCGAAGTGCTGTTGAGCTGTCCGCACCGCTTCCTCGGCGGCCGCAGTTCGGTGCGGACGCCGCCAATCCAATGGATCAGTAGAACGATTTCTGACGCTTCGTCATTGATATCGGCGACCACCTCCCGGATGACGGTGCGAACGATGCGCGTCTTGAGCCTTGCATCTGTCGTCGGCGCCGCCCACACAGCCTTGAGATTGGCGGCGAGCGCGGTGACGTGTATTGGCGACAGAAGTGATGGCTCCGATGTCGAAGCATGCGCGGATCTCGCCGACACGCGTAAGCGTCCGGTTCCATCGCAACTCCAGTTCCGCCGCGACCAGCCGGTTCCGCGGATCGATGGCGTTGTATTGCCGGAACGCCCGATCCGCGCTGTAGCATGCCACCTCGAGATCGCGCATCAGAGCATCGCGGACCTGATCGCGGCGACTAGCCGCTTGCGCTTCGGCCTCGACGGCCGCGGCTGTCGCTTCCCGGTCAACAAACCGCAGAAGAGCTTCCTCGATGGCGTCGTCGACGCGTAGCCCACCGAAGGCGATGCAACGCGGCTCTCCATCGTCAAGCAGACCACGCCAGCAGGAGTAGCGCGGAATGTTGTGCTTGGTTTCGTGTAGCGGACTGTCAGCTTGCGGCCACAGCGCCGGCAGCGGAAGGCCGGGGAGCAGAGCGTCGCCATCATTGGGCGCTCAGTGATGCCGGCCCGTGTTCCAGCCCATGTTTGAGCAACCAGAGCAGGACTGGCGGGCACTGCCGAGTTCCGCCACTTTGTCAAACGCAGGGGTGATGGCCTCCTGCATGCGACGATCGGGATCCTTCTCCAGCCGGTCGCCGACCTTCACGAAGCCGACCGGGGCAGCGACGACGAGTTCTCCGCGCCGGGCCTTCTCATAGCGGGCCGACAGGGAGCGCTGACGCAGAGGATCAAGTTCATACTTGTTAAGAGTGCCCTTCACAGCAGCCGGTCATTGCCTGCCGCGGTGCGTAGGCCGTCTCCTGGTCGATCAGCACGGTATCGACGACGCGGCACATCTCGATGAGCCAGTCGCGGCTGTTGCGGGCAAAGCGCGATACTTCCCGCGCCGCAACCGCCCCAGCCTTGCCGAGACAGACTGCGGCGACCATCCGGTCGCACGGAAACCTCTCTACCAGCCTTCTCGACCAACTCATAAATAGGGCCATGCTCCCGGCCCAAGGATGCCACGGGTAAGAAAGCTCGTGCTCCGCGATACCGTGGGCGTTCTGTCGTCGTGTTGTAGTAGTATCTGCGCCAATCCTCCAACGTTTTTCAGAGGCATCGGCAAGGGTCAGGAACCAATGCCGCCGGATCGACACGTGCCACTCACCACCCTTCTCGGCCACCAGCCCGCGTTTGCGAGCAGGCCTCACAGTTTTCGGCGCATGACGTCCTGCAGCATCTCGTTGGTCCAGGGAGAGATCGGCCACCAGCTTCCTGAGCTTGCCGTTCTCGTCCTCAAGCTGCTTCAGCCATTCATCTCGGGCGGCAGCAGCCCGTCATATTTCTTCTTCCAGTTGAAATAGGTCGCTTGGCTGATCCCCGCGCGCCGGCAGATTTCGGCACGGGAAATCCCGTCTTCCCCCTGCTTCAAAATAAACGCCTTCTGTGCGTCCGGAAACTTCCATGCCTTCATCGTCTTCCGGTCCTTCCAAGGGAATTACCGAGAACGATCCAGTTTTCAGGGATCAGAGCACGTCGTAGACGGGGTAACCAACCGGCGAAGGCGCGTCCGGCGCGGTTGCGGGTCCGCCATTGATGGGGAAGATGGCCCGGTTTCTGAACGGGAACCGTATGATGGTCCCGCACTCACCGAACAGCGAGCCCACGAATATCGAACCAGCATCCCATTGGCCTTGATCGCCGGTGGGGATTGCGCACGAACAGGTCCAATCGGCGGTAACAGAAGCGAGCGTGCTTCATGGCTTGTCTCCTCCTTTGAAACAGGCATCAAGTAGCCCTGGCAGCCCACCCGTTGCGAGGATGTCGAGGCCTTAGCTGCCGGCGGAAGCCGGTCTATCGCGACACGCCGAACTTCAGGTCCACCAGAGAACAAGATCCGGCCGGGCAAATCCGAAAAAGCAATTCAGCACCAGGCGACGCTTTCCGTCGCCTGATCGACCGGTAACCCCGTGGACGAAGCCGCCATCGATTAGGGCGATATCCCCGGCCTTGAGCTGGAAGTCGCGGCAAGGTACGGCCTCGAGATAAGCTGCCGAATAGGGATATCCCGTGGTCTCCACACCCTGCGACTTTCGGTCGATGACTGTCGGCTTATGGCTCCAGAGCCGCAGATTGCCACCTTCTTCGGGAATGCTGGGATAGAAGTTGAATGCTGCGACGGTGTTGTGCGCCACCGCAGAAAGCTCATAATCGTTCCCGGCACATAGGACTTGAGCGACATCGTCGTGGGGGGCCAAGGAAAACGTGCCGGTACCAGACCAACTGAGGGCGCGACAGACATTGGCCTGACCGTGTTCTGAACGCGCCAGCCGCAATTCAATGCCCTTGTTGTGAAGCTCTCGCTTCAACGCGCCGAATATTGCTCGGACCGGGTCAACCAAATTCTCAAAAAGCGCTTCGACGTGCGGTCGCGCCTTTTCGGCGTCTGCGAAATAGCTGGCTGCATCCTTCCTGTAGTGAGATGCGCCGACATATTGTCCGGGCACACCATCGTTACGCTCCTTGAGACCGGCACTACCAACAAAGTTCGTGGTGATCTTCTCGGCTACCTCGGTGCTGAAAGCTTGCTTGATGTGCAGAGCGGTGAGCTCACCTTTCAGGACCGAGATGATTTCCGCAGTGTTGATCGAGCCGATCCGTTCTCTGATCGAAACCGGCGAGATGGCTGGCACTTGAGATATCTGACTAGGCATTGTCTTGCTCCTGTAGTGTGTGTTCAAGGATGGTGATGCCACGATCGAGTTCGGCATTGGTGATGGTTATCGGCGGGAGGACTTTGATAACGTCGCGATTTGGCCCCGAGGATTCGATAAGAAGGCCATTTTCGAATGCGACATCGTGCACGCGGCCGACAACTGCCGGTGAACGGCATTTCAGGCCGGCCATCAGACCGCGGCCGCGCTTCTGTTCGATGTATCTTGGAAATTTCGCAACCAGGCGATCGAGGTGGGTTTGCAGCCTGACGGCTGTCCGCTCGACACCTGCAGTAAATTTCCTATCCGACCACATCTTGCACATGGCTCCTGCCGTCACGAAGGCGAAATTGTTGCCTCTGAAGGTCCCGCTGTGTTCTCCGGGCTTCCATATGTCCAAGTCGGGTCGAATCAGAACGATAGACAGCGGGCTACCTGAACCGCTTAGGGACTTGGAAAGACACACAATATCCGGTTCCATTTTCGCGGACTCGAATGAGAAGAAATCGCCAGTTCGGCCCGCGCCCGCCTGGATATCGTCGACGATAAAAACAATGCCGTGCGTACGGCAAATGCGCTGAATTTCCGTGAGCCAAGCCGCGGACGCGGCGTTCATGCCGCCTTCTGCCTGGATGGTCTCCAGTATAATTGCGGCAGGCTTTTCTATGCCGCTCCCCGGGTCGCTCAAAACGTGGTCGATGTAACTGGCGGAATCGAAAGCTTGGCTCGGATAGCCGTCATAGGGAACACGGATCACATCGTGGCGAGCAACGCCTCCCAGTTCCCTGGTTGAGGCCGAGCCCGACACCGCGAGAGAGCCGAGCGACATGCCGTGGAACGCATTCGTAAAGGCCATGACGCTCGAGCGGCCGGTGTATTTTCGCGCCAGCGCCAGCGCCGCTTCGTTGGCGTTCGTGCCGGTCGGCCCGGGAAACTGAATCTTGTACGAAAGGCCTCTGGGTTTCAGGATCCAATCGACGAACCCTTCAATGAAGTCACGCTTTGCCGCCGTATGCATATCAAGCGACAGAAGAATGTTCTCACCGACGAGATATTCAATCGCTGGCGCCATAATATCCGGATTGTTGTGCCCGTAGTTGAGTGCGCCGGAACCCACCAGGAAATCGATAAAGGGCTTACCCGTCTCGTCCCAGATCGTCGCCCCAAGGGCCTTCGTAAAGACGGTGGGGAACGCCCGGCAATAACGACGAACGTTAGATTCATGAGCCGTGAAAGCGTCGGTGTCCATATCAAGTCCTCTGCACATAGTCTTTCAAAGAAGAGAGCTGTTTAATGGCTAGTGGTTTGCGGCAGATGTTCGTCGCTTAACGTTGAAGCAGAATGCCGGAGGCAGCTTTGTTTGGTCTGGGTTTGGTCTGGTGATGCCGGCATCCTCATCAAATATTGTTGGGTGGCGTTGCCCTCCATTCGGATGCTTTCGAATGTGCTGCAGCAGGATGGCTTCTAAAGCTTCCGCGAAAGCATCGCTACTATGGCATCAGGTAGTTGACGTACCACCCATCGCTGCCCATAGCGCCTCCGGACAAATGTCCAAGGAGATCAGCAGGGTCGCGTCGCCAGAGGTTGTGTCGCTCGGCGGTAGCGAAGCCGCTCGCGAGCGCGCTCCTCAATAGCGCCGTAGCGAGCGAGCGGCTTCGCGGCGGTCATCAATATTCGCCGTTCAACCTCGGGCTGCGGACACCAACCTGATTCAAGAAACTATTTGATGACCGATGACACAGCGAAAGCCACGCTCTCTTTGAGAAGAATGCGGATTCCGATCTCTTGCGCGATGACTGGCCCGAGCCGCCGGATCAAGAGGGCGGGGCCGCCGTGGACCCCCTTGACGGAAAGCCCGTTCGTAGGCCAGGCGGAAGCAACCGGGAGACGCGCTGGCGAAGGGCCGCATCGGTTTCGAGAACGTCCACTACCGCGACGGCAACCATCCCCGGCCGCAGCTGGGCTGCTGCCTTCAGGCGAGTCGAAAAGGAGATCGTCCGGGAGGGTGAAGGCGTTGACGAGGTGAGCCGTGAGTAAGCAATCAAGCTCTGATCGGGATCGACTAACACTGTTTCCATCCGACCGATGGTTGACCTGTGATCGGCGTTACCTCAAGCTAGGCAGGCCGACAAGCTCGGTTGGAAGGCGAAGACCTTTCGATGAGCTCGTCTCCGAAATGCTCGAGGCCCACTGCCGCGCCTACAGGAACATACTGGCGTAACGTGAAAACACGATGGCGTCGCGGGCAGGTGCATCTGTCGTGGGGCCATCCGCACTGCCAGGCACGCCCTCTCGGCCGGCATGCACTCAGGTCCGGTCGTTTGGGTCGGCGAATTCACACATCCTGCAAAGCAGAAAACCATCTGCTCCATTCATGCGGTCGACGATTTCGCGAAAAACTGGCTTTTCAAACAGAGCGGAGTAACCCTCATATAGAAGGTTGCCCAATACGTGACGCCGTTCAAAATCCATAGAGCACAGGGTAACGTCGCCGTTTGGAAGAAGAACATTCCGATACTGTCGTGCGTCCACGCAGGTTAGGGCTCCGACCACTGGCTGACGTGGTGCAACGATCTTAGGGTCGACGCTTCCACCCCTACTGCTCACCGGCCGCGCTTTTATCAGGGCTTCGGTAGGAATAATGTCGGCTATATCTGGGTGGGGCTCGCCCAAGGCCACGAATCGGATCAAGGGGATGTCCGCGTCGACGAGTTGACGAACCAGATCGCGATACTTGTCTCCGACCAGGCGGCTGTTCATGTAGGTGCCGTCATCGAAAACATGGACCACGAATACGCCCAAGGGCAAGGCTTGCAATCGCTGCAGGTCCTGCCCGTTCATTCCCACCAGCGTCGTAAAAATCCTGATGCCATGGCCTTTGGCGAAAGCGTGCTCCACCATTTCGGTACAGTCCGGATTGAGCCAAGGTTCGGAGTATCCCGCAAAACCAATGTCGACGGAAGTCGGTACGCGGGCCAGACACCGCTTGAAATCTTCAAGATCCAGATGACTCGCATGAGACACTTTTCTTTGCCGGACCGCGAACTTGTCCTGGGGACAATATGAACATCCTACGACGCATCCCGTGGTCGTCGTTATCTCCAAAACCCTGCCGGCTGTGTTTGCTGAGCGAAGTTCCGGTAAAATCACTGGTGATTACTCCCATCTACTTCCTGCGAAGCGCCACGATGGTGTGCGTGTGCCTTTGGCTTTCTGATACCGCCTGCTGATCTACCGAGGCAACGCAGACATCTACCCTTTTTGGCAGCCTAAGCCGCCCGGTTCACCGACTTGCCGGGCCGACCTTCACAAACTTCCAGCGCGTCGGACCAGAGACAGCATTGCATCTTTCGAGGCATCACTCGCTCCGGAGATGTAGCCTCAACCGTTGGTCGCTGGCCCGTCGCCGAGATGCGCGCGCAGCACCCTCGAACCCGCCGGAGAGAAGCTTTCTGGATGCCGTCGATCATCCTTCATCGAGCGAGTTCCGTGTTCTCATGCGGGTCAGCCCTCACACTATATTGCCGCACATCGACCAGCAAAGGCCGAGCTAGTGCGCCTGGCGCGCAGTTACTGCGAGATAGGCTTCGAAAAGCCCGACAGAGCTAAGACGCTCCGCTGTATTGAACCCGACATGTTTTCTGACAGCTGTCAGATTTTGGACACACATCACTCATCGTCAGTCGCTTAATACGGATGGTAATTTCTTCCAGGAATCGGTGACATTGAACACCACCCTGTCATGACCGCCCAATCTCAGCGAAGCGAACTCAGCATCGCCACCAGGACCAAGCCTGAAGATAAATCCGCCATAGCAGCGTCAACGACATTTTGCTTTCGAAGCCGATGGATTGCACGAGGTGATTCGCGCCGTGATGCAGGAGGTGCTCGAGGCCGAGATGGACGAGGCGCTGGGTGCTTCGAAGAGCGAGCGCACGCCGGAGCGTCTCGGCTATCACGCGCGCTACTACGGGCGGAGAACTAGCTGCGCACCTACGGCGGTTCGATAATCCCAAGGTTCAAAGCTTTTACAACAGCTACCGTTCTGCTGGTCGCATCCAACTTCCGCATTACATTTTTTAAATGGAAATCTATCGTATTTCGTGATCTGCCTAAAATAGTTCCTATTTCCCAAGATGATTTTCCTTGTGACACCAAATCAATGCACTCTATTTCTCTCGGAGACAGGTTATGAGCTCGTTCCGACGCAGTCGTAGTGTCGAACTTCGTAACCATCCGATGAAACCGCAGCGCGGCCATTTGCAGGTAGGTGATCGCTCTATTCTGCAATTCGCAGTCCGAGGATTGAGCAAAACTCACAAACCTAAAGCTGCCACCAGGGCCATGTAATGGGACGGTAACGCCTGACCTCAAGCCGAATGTTGCTGCTTCGTCCAAGACGCGGCGTCCATCTTCAGTTATGTTTTCATCAGTATACACCTCGCTCCATCGAAAGGGTCCCGCCTCCTTTCGACCTTTCTTGATGAGGGGGTCTATTTTGGCATAGCCCATTCTCGAGTAGCGCTCCTGCCATTCAGCAGGATAATTCCACATCACCACAGAACCCTCTCGGTTCGGCTTGAAAGCCCTCTCTGATGCGAGCGGCCCATAGGCAATCCACGGGCAATCGAAATTCAGCGCAAACGCAGACAACAGTTCGAACAACTGTTCGGATTGAGCGACATCATCAGTCATCTTGAGGAATAGGTCTAACTCCACCGCAATCCGCCGGAGTTCCATGATGTCTCCTTCATTGCGTTCTCATTGGTGCACAGTTTGCTCCAACCCAGCCTCGCAACATCCGAAGTCAACGGGACTCGAGCCGGAGTTCCTTCCGCCACCTGGAGTACCCTCAAGAGTCGTGCCAGCTTGCGAGCGAAGCTTCTCCTTCAGGTCGTCAATCGACGGGGGAGGTACCCAGGAGGCGAACCGACAGCACTGTGTCGGGGAGCGCACAATCCGACAGTCGAGCATCCGATTGACGGAATATGGGCAGGAAAGTATTCGCGGCGCGCTTTTGAAATCAGCACCTAAGTGCCGGGCCTGAGAAAGCTGCATTGCAACTGTACTTATTTGATCGAGGCAAGAACAAGCTCAAAATTCAATCGATACATCGACCTTCTTTTCCAATCTCCCGAGTTGAGCAGCCGTAGCAATCGTATTCGACTGGATGGCGGCTGACTTTCTCCAGGCTCGGTAACCTGCTGAATTTGTCCTTCGGATGTTCCCGCTCAGTTGGCACGACTTTTGAACTCACCGTCGTGAGGCGGCAAGAGCTGCCCGCCAAAATTGATGCTGTTATGGGGGAGGTCGAAATTCCAGTTTTGTCTTTTATCGTCTTTGGGACCGAGCGTGTTGATGCGCCCGCTTGGAAACTATGAGACGTTTCCCCGTCCATGGGCGCGGCGCCACTTGTCGCGACGTTTTCGCCTTCACTGTTCGCCTCTGGAACAGGCAGCCGGCCCGGCTCGCGATCATCATGACCGCGATGCTCGCCTCCACGCTGGCTGACGTGTTGATGCCGCTCTATTCTGGCCGACTCATCGACGCTGTTTCTCGTGCTGCTAATGCGGCAGCACCAGCTTCGGATTCAGCTGTTGCAGCATTCTCTGTACCGATTGCATTGGCACTCGGTGGCATTGCCATGCGCCACGTCGCCTTCATTGGCCTGAGCGACCTGGTGTTGAAAATGATTTCCGACGTCGCGACCGAAGCGTTCCATCATGTGCAGCGCTTTTCGACAGACTGGCATGCAAACAGCTTCGCCGGCTCGACAGTGCGCAAGATAACGCGCGGCATGTGGGCGCTCGACCTCCTCAACAGCACGATACTCGTCACGCTGCTCCCGTCGTTTGTCATCTTGATCGGCTCGACGGTGCTGCTCGGCTGGCACTGGCCGGTCATGGGCGCGATCTTTGCTTGCGGCTCTCTCGTCTACCTTGCGTTTTCGATTTCGCTGTCGCTCGGCTATGTCGCGCCAGCGGCGAGCCTTGCCAACCGATGGGACACAAGGCTCAGCGGCGCGCTTGCGGACGCGGTCAGTTGCAACGCTGTGGTCAAGGGCTTCGGCGCAGAGGTTCGCGAAGACGAGCGGCTTGCAAATATCATGACGAAATGGCGGCACCGCGCGCGCCGGAGCTGGGTGCGCGGAACGATCATCGGCTCAACCCAAGGCGTAACTTTGGTTGCGCTCAGGGTGGCGGTGGTCGGATATGCCCTGCTTCTGTGGTCGCATGGACAGGCAACGCCGGGCGAGATAGCATATGTTCTCACGTCCTTCATCGTCCTGCAGGGCTATCTGCGTGATGCCGGCATGCATGTCCGCAACGTGCAGCACTCGGTTAATGAGATGGAAGAACTAGTGGCCATCCACAATCAGCACGTGGATGTTGCCGATCGTCCAGAGGCCAAGCCGATCCGGATCACGAAGGCCCGTATCGATTTCGAGAACGTCCACTTCCGCTACGCCAACCATCCCCTGCCGCTCTATAGCGAATGTTCGCTGTCGATTGAAGCTGGCGAAAGGGTTGGGTTGGTTGGACCCTCCGGTTCCGGCAAGACAACATTCGTGAAGCTGATCCAGAGACTCTACGACCTGAGCGGCGGCCGGATCCTGATAGACGGTCAGGACGTCTCCGAGGTGACCCAAGAGTCCCTTCGTTCGCAGATCGCGATCGTGCAGCAGGAGCCGATCCTGTTTCACAGGTCGCTTGCCGAGAACATCGCCTATGGCCGGCCTGGCGCGAGCCAGGCCGAGATCGAGCAAGCGGCACGACTGGCAAGTGCCCACGAATTCATCGCGCCCCTGCCGAAGGGCTATGGGACATTGGTCGGCGAAAGGGGTTTGAAGCTCTCCGGCGGCGAGCGCCAGCGCGTGGCGATCGCGCGCGCCTTCCTCGCGAACGCGCCGATCCTTATTCTGGACGAGGCCACATCGAGCCTCGATTCGGAATCCGAGGTGCTCATTCAACAAGCGGTGGATCGGTTGATGGTGGGCCGAACCACACTCGTCATCGCACACCGGCTGTCGACGGTCCGCTCGCTCGATCGGCTGCTCGTCTTCGACCGTGGCCGCATCATGGAGGACGGCGATCATGCCGCCCTGATCAATCTCGATGGTGGCATTTACCGCCGCCTCTTCGAACGGCAGGCGTTGGAACTCGCGAAGGGCCTGGCCTGATCGCTAAACCGGCTTGCGCGATGCGCCGAGCCGTTGCCGGAGAGGGGTGTGGCAGTGACCAGCGGCGGGCGTTAGGCGGCAAAACCAGCACGGCAGGAACTGTCCGCCAAACGGGCGAGCGGGAATGCACCACGTCTAAGCTTCGGCGAATGCGCGCAGTTACACGCGGGCACCGAATTGTCGCGCCTAACGGCGCACGCACCAAAAGGGCGGGAATGTCGACGGCCCGGGAAGAGTGCGGCCCTCGCCGTTACCCACATTTCGCCAAAGGAAGCGAAGTCAACGCACATTGAGAGGGCGGTGCTTCCCGGCCGGCTGGGATCCCTGTCGCTGGCCCAACCTACCGCACGCCGGCCACGTCAACGGTTCAAAGTCCCTTCGGTTCGCAAAGTCGTCCCCTTGGAGACCCGGAAGCGCAGGAGCTCCGACCGCAGTCTTCGCTCAACTCTGGCCATCTGCTCCGGGATTGGATTCCGTTCCCTTGCTAGCACAGTGGCAGCTGAGCACGAACTCGCCGGCCCCGTGTCTTTCGATTACGGCCAACGGGCTTAGGAAGAGATTGGATTCGCCGGCCCTCTGCGGAGCGAATGAACAGTTCTACAGATCATCGACGTCCGCGAAAAAGAGCACGCAGCCGAAGTAGCCGGCCTGAAGCAGCAGCGAACAGGCCAGCGTCGTGACGACTGCCACACGGAGCGAATCCAAAGCGAAGTAAACCATCGACGCATTGCTGCACAGGACCAGCCCCACGAGCCGACAAAAAGATGAAGTGCAACGCCGTTCTCCTGGTTTTCGCCAGATCATGTTGCGAGCTCGTCGGCCGCAACATGCGTCTGGCAGTTCTTGGGGCAGACGCGGCCGCAGGCTCCGCAGCCGATGCAGCGGCCGGCATCATCGACAACCATGATCATGCGATTGAGCTTGCCGTCGAAATCGTCGTCCTCGTCATCGCAGGGGCCGAGGATTTCACCCGCATCATCAACGCCGTGAAGATGCATGACATCGCGCGAGCAGACCTTGAAACAACGGCAGCAGCCGATGCAGGTCTTGCTATCGATGGAGGTCAGGTACGACGGCATCCAAATGGAGCCGTCACGGGTGGTGAATGTGCGCATCATCCTAAATTCTTCATTGAAGCGAGTTCTCTCTTGGCAACATCCAACTCGGCATAAACGGCTTGGGTTTTCTCGGCGACTTCCTGTATGTCGGCCCACTTGCCCGGCAGACCCTCGACAAGGTCCTGCAATGCCATCTTGGCAATAGCTGCACGCAACTGGAGCTTTCGGACTTTCTTCCTCATCTTATCTAGGTCTGACATAGATCCTTCCTGGAACAATGGTTTTGTTGATGCGCTCCATCTCGGGCTAGGCTTCAATGGCTGCAGTCGCATCGTCGACCAGTTTCGTACCGGCCTCAGCAAGTTTGCGGAAAGTCTCGAAGCCGAACCGGTGGACGTCTCGACAGAACGCCCAACCGCTGGAAGCCCGCAGGGGCTTCATTCCAATTATTGGCGACGTCGACACGCCGGAGCGCTCCTCGATCGCAAGCGCTACGGCGGTGTAAAACATGTCGAGCCTCCACAGCGCGTCAGGATCGGGATCGCCGCCAAAGGGTACCGCACGTTGCTGTTGCTTGGTGATGATGAACTCGGCCAGCAGCTCGGCATCCGAATGGCCTTCCCATAAGCCGAAGGAATCCTGAGTACGAATGAGCCGCAGGAGGCATTTGACGAACGGGGAAGCAAGGGCCTCGTCGTCATTGTTGACAGCAGGGCCAACCGGAGGAATTTCGTTGTTCGTCATTTCAGTCTTCGTCTTCGAGGTACGATTTCCTTTTCCTGCGATGCCCACTCCGGGTCCGCTTGCGTGGCCGACGAATGGCTTGGGCGGGCCAACCCCAAGAGTGCCCCGTGGCCGACCTCGACATGTCCACGAGTGCGAGACCTGCGGCGCGAATTCGCGGCGCACATCGTCTGCGCCGCGATCCGACCGGTGGTCAACGCAATTGAAATCCAACCTTCCGCAAGCCGCCGCCTGCTGCATCGACATACTTGCTGCGAAGAGAGCTTCGATGGGCGGATTGGCCAGTGTTCAATTCCAATTGTCAGTCCCTTCGCGATTCTTGCTCAGGAAGTGACTGCGTTTTGAGTTTCGGGTGCCTTCTTTTGCGGAGCCACACAAAGATCCGCGTGACAGGCAGGCTCACCCGTGTAGTTGGCCAGTGCTTCGAGCAATGGGGTAAGATAGTACTGTTTGGTGTGGTCCGGAATTGGCCCCAGCCGGTCCACCGATTTCAGTGCCACCTCGATCAACTCGATTGCGCGATCTTTGTTGCCGCTCTCGTAATAATACTGAGCTACCGGGAGGTACCGGAGGTATTTAAACGGGCCATCGCCGTTCGGGGGATTGAGTGCCAGTATCTGTTCCGAGAGCTCGTTGCCCATCGCAAAGCGCTCCGCGCGCGGAAGATGGGAATTGTCCATCGTGGGATCGAAGAGTTGGTTGAGGGCCAAGGCCATCCACGACACCGCGTCGGACGTTTTGTCGATCGCGTCCTCGACCAATTCTCGCATGACCGGCATGCCGGTCTTGATGTCGCGCAGCTTGTGAAGCAGAAGATCCGCATGAATCTGCCGGAACTCACAAGAGTCTGGCATCAAGGCGAGGCCTTCTTCGATGGCCAAGAGCGCCGCCGTCCAATCCTCGGCCTGCATCGCCGGCTCAAGTTTGGCGTATATCGGCCCGGTAAGCGACATTTCGCGCGCTGCAAGTTGGTTATGCGCGATGCGCTTTGCATCGGCGGCTTTCGCTTCATAGCTGCTGCGCCAGCTGCCGTTAAGGACTTTCGGCAAAACGTCATCGAGTTCCGCCGGGTGGCCGATAAAAGCGATGTGGCCGTCGCGGTCGACCACGAACGAGGTGGGAATCCCAATCGAAGAGCTGGGATCCAGCCAGAGCTTGTTCATTTCGCCAATGTAATCGAACCCGATACGATAATTCAGATTCGGGAACTTCTCGGTCAGCCAGGCATCCACGTTGGTCCGCGCCTCGTCTGCGGTAGGACCCTGTTCGCAGGCGGCAACTCCGACCGCCTCAAATCCGCTGCCTTCATATTTCTCCTGCAGTTCGATCAAATCGGGCATGGCGTCGACACATGGTCCGCACCAAGTCGCCCAAAACTCAACGAGGTAGACCTTGCCGGGCCGAAAGTTCGTGAGGGGCTCGCCACGCAGCCAGTTCTCCACTTTGATCGCAGGAGCCGGGGACCCCATACGCAGTTCCATCTTGGTGTCCAAAGTCATTCCACACCTTTCGTCTCTTTTGTCGCGGAATATTTTCCAGTCAAAATCGGACACGGTCTCGAGGGCATCGCTCCCTCTGGCTTGCTTCAGCGAAGCTCTCACCGTGTTGCCGCACATCAAGCTGCAACGGAGGTGCCAATTCCCTCAGCTCCGGTAAGCGGCGGGAAATGCTTTGAAATTCTCCACGAGGCCAAATGCGGCCGATTGTCGTGAACCCGACATGTCTTCTGCCGCTGTCGGGTTTCGCCCTATCACTCTTGAGAGCTTGGACGGCTCGCCTGTGATTAGACTGGCCTCGGTCCTCGAGCAGTGGCAGTTTGGCGCCAGTTCGAAAGCGCGAACTCGCCGGCTTGGTCCTCGTGCCGCCACCGCCGCGTGTGGATTCTTGCCCCGGAGTCAAAATTCGCCTCGCGGTTGCCAACGGCGGCATGCGCTCAATGCGCGTGGCGTTGAGCCCCGACAGCACGTAATGGTACCAATTAGTGGATGCCCGTCGCTGCCTCCACTTCTCCAGCCAAGCGCTCGAACGACGCTACCTACCCACGTTCGAGCGCGACCGCGGAATCGCAGACTGCCGAACGTCAGCCGTTGCGAAAGGTGTAGCCGTACCCGTTGATCGCCGGCGCGCCGCCTAGATGTGCGTAGAGGACCCTCGATCCCTGTGGAAAGAAGCCCCTCTGGACGAGGTCGATCATCCCTTGCATCGATTTGCCCTCGTAAACGGGGTCCGTAATCATGCCCTCGAGCCGCGCGCACAAACGGATTGCCTCTTTGGTTTCCTCCGATGGAACGCCATAACCCGGGTACGCGTAGTCCATGAACAACACCACGTCTGCCTCGACAATTTCCGCTCCGAGGTGGACGAGCTTCGCTGTATTTTGGGCGATGCCAAGCACCTGCGCCTTGGTCTTGGCGGGCATGGCGGAGGCATCGATACCGATCACGTTGCGCTGTCGACCATCCTTGGCGAACCCGACGAGCATGCCGCCGTGGGTTGAACCAGTCACCGTACAGACGACGATATAGTCGAAGGCAAACCCAAGCTGCTCTTCCTGGGCACGCACCTCCTCAGCGAACCCCACATAGCCCAGGCCGCCGTATTTGTGGACAGAGGCGCCGGCAGGTATCGCATATGGCCTGCCGCCCCTTGCCTTGACTTCATAAAGTGCCTTTTCCCAGCTGCGGCGGATGCCGATGTCAAAGCCCTCGTCAACCAGGCGCACCTCTGCCCCCATGATGCGGCTCAAGAGAATATTGCCGACCCGGTCGTAGACAGCATCATCATGTGGGACCCAGCTCTCCTGGACCAGGAGGCATTTCATGCCGATCTTGGCGGCGACCGCAGCGACCATGCGCGTATGGTTGGACTGCACGCCACCGATTGTGACGAGCGTATCGGCATCTGACGCGATCGCGTCAGGCACAATGTATTCGAGCTTGCGCAGCTTGTTTCCGCCGAACGCGAGACCGGAGTTGCAGTCCTCGCGTTTGACGTAGATTTCCACCTTGTCGCCCAGATGCTTGCCGAGGCGGTCGAGCCTCTCGATCGGCGTGGGTCCAAAGGTGAGCGGATAACGTTCGAATTTTTCCAGCATGCTATCTCCAGCAAAAAAGTACCTGAACCTGCTACGCACCGGTCAGCCCAGGGGTATGGTCGCGTGTTAGCCGAACACAGATTCCCTATACGATCAGCTCAGTCATCAGAGGGTGACCAAAATTGGTGTGGGTCTGAGCACTGATCCTGTCATCCGCGCATCAAAGCAGCAGCACATGCTGGGCATTCGACCAAGCCGGGACACAGCTGAAAATTGCATTCCGCAGTTGATCAGAGTCAGACGACTGGTACCCGAGCTTTCCTGTAACCATCGGCATGCTGGCCCCTGTGGCGAGTTCCACGAGCGCGGCTAGAGGACTGCCAGATCAGAAAGAGCACGCGGCCGAAGTAGCCGGCCTGAAGCAGCAGCGAACAGGCCAGCGTCGTGACGACTGCCACACGGAGCGAATCCAAAGCGAAGTAAACCATCGACGCATTGCTGCACAGGACCAGCCCCACGAGCCGACAAAAAGATGAAGTGCACGCCGCTCCCCTGGTTTTCGCCAGATCATGTTGCGAGCTCGTCGGCCGCAACATGCGTCTGGCAGTTCTTGGGGCAGACGCGGCCGCAGGCTCCGCAGCCTATGCAGCGGCCGGCATCATCGACAACCATGATCATGCGATTGAGCTTGCCGTCGAAATCGTCGTCCTCGTCATCGCAGGGGCGAGGATTTCACCCGAATCATCAACGCCGTGAAGATGCATGACATCGCGCGAGCAGACCTTGAAACAACGGCAGCAGCCGATGCAGATTTGCTATCGATGGAGGTCAGGTACGGCGGCATCCAAATGGAGCCGTCACGGGTGGTGAATGTGCGCATCATCCTAAATTCTTCATTGAAGCGAGTTCTCTCTTGGCAACATCCAACTCGGCATAAACGGCTTGGGTTTTCTCGGCGACTTCCTGTATGTCGGCCCACTTGCCCGGCAGACCCTCGACGAGGTCCTGCAATGCCATCTTGGCAATAGCTGCACGCAACTGGAGCTTTCAGACTTTTTTCCTCATCCTATCTAGGTCTGACATAGATCCTTCCTGGAACAATGGTTTCTTGATGCGCTCCATCTCGGGCTAGGCTTCAATGGCTGCAGTCGCATCGTCGACCAGTTTCGTACCGGCCTCAGCAAGTTTGCGGAAAGTCTCGAAGCCGAACCGGTGGACGTCTCGACAGAACGCCCAACCGCCGGAAGCCCCCACGGGTTTCATTTCTATTGTCGGCGACGTCGACACGCCGGAGCGCTCCTCGATCGCAAGCGCTACGGCGGTGTAAAACATGTCGAGCCTCCACAGCGCGTCAGGATCGGGATCGCCGCCAAAGGGTACCGCACGTTGCTGTTGCTTGGTGATGATGAACTCGGCCAGCAGCTCGGCATCCGAATGGCCTTCCCATAAGCCGAAGGAATCCTGAGTACGAATGAGCCGCAGGAGGCATTTGACGAACGGGGAAGCAAGGGCCTCGTCGTCCTTGTGGACAGCAGGGCCAACCGGTTCATGAGGAATCTCGCTTTTCCCCAATTTCAGTACTCCTCTTGAAGGACGATCTCTTTTTCTGCGATGTGTGGTTCGGGCGCTTGCGTGGGCGGGGAATGGCTTGGGCGAGCCGATCCCACGCAACAGTGTCCCGTGGCCGACCTCGAGCACGTCCACCAATGCGAGACCTTTCACCGCGGCGCGAACGCCTGCGCCGCGGTTCGACCCGAGGTAAACGCAATGGAAATTCCACCTGCCGCAAGCCGCGCACTTTTGCGGCATCGACGTTATTGCTGCGAAGTGCGCCTGGGCGGGCGGATTTGCCGGTGTTCAATTCCAATTGTCATGCCCTTCGCGATCCTTGCTCAGGAAGTGACAGCGTTTTGAGTTTCGGAAGTCTTGTTTTGCGGAGCCACACAGAGACCCGCGTGACAGGCAGGCTCACCCGTGTAGTTGGCCAGGGCTTGGAGCAACGAGGTGAGGTAGCGCTGTTTGGTTTGGTCCGGCACTGGCTCCGAATGGTCCAGCGATTTGATTGCCACCTCGATCAACTCGATCGCCCGGTCCTTGTTGCCGCTCTCGTAATAATACTGAGCGACCGGAAAGTAACACCCGAATTTAAAGTCTCCATCGCCTTGCGGAGGATTAAGTTCCAGGATCTGTTCGGAGAGCTCCTTGCCCATCGCAAAGCGATCATCATGCGGAAGATGGGAGTTGTCGATCGTGGGATGGAAGAGTTGGTTCAGCGCCATCACCACCCAAGACATCGCTTCGAACTTTTTGTTGATCGCGTCCTCGACCAATTCGCGCATAAGCGGCAAGCCGGTTTTGATGTCGCGCAGCTTGTGAAGCAGAATATCCGCATGAACCCGCCGAAAATCAAAAGAGTCTGGCATCACGGCGAGGCCTTCTTCGATGGCCAATAGTGCCGCTGCCCAATCCTCGTCCTGCATCGCCGGCCCAAGTTTGGCGTATATCGGCTGACTCAGCGACGATTCGCGCACACGCGAGATTCGCTTTGCATCGACGGCTTTCGCTTCATAGCTGCTGCGCCAGCTGCCGTTAAGGACTTTCGGCAAAACGTCATCGAGAGGTGCCGGGTGGCCGATATAAGCGATGTGGCCGTCGCGGTCGACCACGAACGAGGTGGGAATCCCGAACGAAGAGCTGGGTTCCAGCCAGAGCTTTTTCATTTCGCCAGTGCAATCGAACGCTGTCCGATAATTCAGATTCGGGAACTTCTCGGTCAGCCAGGCATCCACGTTGGTCCGCGCTTCGTCCGCGGTTGCAGCCTTTTCGCAAGCTGCGACTCCGATAATCTCAAATCCGCTGTCTTTATATTTCTCCTGCAGTTCGATCAAATGGGGCATGGCGTGGACACATGGTCGGCACCAAGTCGCCCAAAATTCAACGAGGTAGACCTTGCCGGGCCGAAGGCTCGTGAGGGGCTCGCCACGCAGCCAGTTCTCCACTTTCAGCGCAGGAGCCGGGGACCCCATACGCAGTTCCATCTTGGTGTCCAAAGTCATTCCACACCTTTCGTCTCTTTTGTCGCGGAATATTTTCCAGTCAAAATCGGACACGGTCTCGAGGGCATTGCTCCCTCTCGCTTGCTTCAGCGGAGCTCTCACCGTGTTGCCGCACATCAAGCACGGCAAAGGGCATGCCAACCCTTCTTAGCTTCGGCAAGCGCCGGTACCGCCTTGAATAAGCGAGCCCTAACACGGCCAGCTGACGTTAACCTGAATGTCGGCTTTCGACGGCTCACCTTAGCGGCTGCCGTTTAGGAAGGTGAGAGTTTGGCTGGCCCGCTGGCGATAAGACCGGCTTCGGCGTCCTGGAGTAGTCGCACTTCGGCGATGGGGTCGAAAGTGCGGGAGAGGCTCGGTACCCTTGCAGCCACCGCCGCATGTGGCCCGGCGTCATAATTCGCGTCGCGGTTGCCAACGGCGGCGTTGGGCTCGATCCACGTGGCGTTGAGCCCGACAGCACGTAAAGCTGCATCGTGATTGAATGCCCTTTGCTGTTTCACGCCAAGCAGGAGTCGCGCGACGCTACCTGATCGTGCCCACTGGAGTGGTGTAGCTGACGGCATTGGTCGCCGTGCTCTCCGGCATGGGCCGGAATTGATCAGCGCGCCACTGCCGGCAGGCTGATGAGCGGATCATCGCTCATTTGGCTGATGGTCTCAAGAGTCATGTAGCGCGCCCGCTGCACGGCCCATTCATCATTCTGTTCAAGCAGCAACGCGCCGACGAGACGGACAATGGCATCGTCATTGGGGAAGATGCCGACGACCTCGGTGCGCCGCTTGATCTCGCCGTTGAGACGCTCGATCGGATTCGTCGAGTGGAGCTTGGTGCGATGTTCCTTGGGGAAGGTCATGTAGGCCAGCACGTCGGGCTCGGCCTCGTCCATGATTGTCGCCAGCTTCGGCACCTTCGGCCGGATCTGGTCGGCGACGGCACGCCATTGGGCGCTGGCAGCCTCGGGCGTCTCCTGGGCGAAGGCGGTCGCGATGAAGGCCGAGACGACCCTGCGGCCGCTCTTGCCGGCGTGCGCCAGCACGTTTCGCATGAAGTGGACCCGGCAGCGCTGCCATGTGGCGCTGAGCACCTTGGTGACGGCGGCCTTGAGGCCCTCATGAGCATCGGAGACGACAAGCTTGACGCCGCGCAGGCCGCGACGGGTCAGCTTGCGCAGGAACTCGGTCCAGATCGGCTCGGCCTCGGAGGTGCCGACCTCCATGCCCAGCACCTCGCGGCGGCCGTCCGCGTTGACGCCGACGGCGATGATGACGGCGACCGAGACGATGCGGCCACCGCGGCGCACCTTCAGGTAGGTGGCGTCGATCCACAGGTATGGCCAATCGCCCTCGATCGGCCGCTCGAGAAAGGCCTTCACCTTGCCGTCGATCTCCTCGCAGAGCCGGCTCACCTGGCTTTTGGAGACGCCGCTCGCGCCCATCGCCTTGACCAGGTCGTCGACCGAGCGCGTCGAGATGCCCTGCACGTAGGCCTCCTGGATGACCGCGGTGAGCGCCTTCTCGGCCATGCGTCGCGGCTCCAGGAAGCTGGGGAAGTAGGAGCCCTTCCTCAGCTTTGGGATGCGCAGCTCGACCGTGCCGGCCCGCGTCTCCCAGTCCCTGTCGCGATAGCCGTTGCGCTGGACAAGCCGCAGCGGGTTCTTCTCGCCATGGGCCGCGCCGGTCGCCGCGCCCACTTCCAGCTCCATCAGCCGCTCAGCGGCAAAGCCGATCATCTCGCGCAAGATATCGGCGTCGGGGGTCTTCTCCACGAGCGTGCGCAGGTCCATCATGTCGTCGGTCATCGGTGCTTCCTTCGAATCAGGTTGTGTCAGCAACCCAACCCTACCGAAGAACATCGATGACCACCGCTACGCCGCTCGCTCGCTACGGCGCTGTTGAGGGCGCGCTCGCGAGCGGCTTCGCTACCGCCGAGCTACACCACTCAGCGGGGCACGACCCGCTACCTTGCTCAAGCGCGAGCAGAGCGATCTGACGCCGTAGGAATATTGCTCGTCCCGCTTTTGCCGCCAGAGGCGGAAATCTTTCCTGAATGCCACCGCCGATCATCAATATCGACGAATCATATCCCGCTGCCCATTTGTTCGACTCCGAGGTCGGGCCAGCACTCCGTCAAGGGACGGTTGATGAACCCTAGATGCTCGGGATTGGCGCATGGCGCGCGCCGCAGAAGGCTGTCAAGGATGCGGCGCGCTCGCCAGGCCAGCAGCCCAAAGTTCGGATCAGCCAGCCCGCGCTGTCCAAGGCAGGCGTTCTGAACGAAAAGGCGTCGGTCTCGCGGTCCGTCCCAGTACACCGAAAAATCCTCGCCGATGGCGAGCTCATTGCCGATCTGTTCGAGGCGATCTGCGATCGGTTCTAGGAAACCCGGCAGCGGTTTCTCGTACCCGGTGGCCAGGATGACGATATCGGCGGTTACTTCTCCGATGTTGTCCAAGCCGCGTTGCAGCGTGAGCCTGTGCCCTGCTCCGGCATTGATGCAGCGCGACACGTTGCAACTTGGCCTCAATGTGATCTCGCATTGGTGTGGCTCGAGAAAGGCGTGGTGGTAGAGCGCCTGATAGACCGCGCGCAACTTGCTTTCTGAAATGCCCTCGGAGGCAAGCGCGAAACGCCGCAGGAACAGCTGTCGATGCACCTCGCTCATCGCAGCAAAACGATCCGAGAAGCATGGCGTGAACAGCCCGTTTGTGAACGCGTGGTCGTCGAAAGGCATCTCGCGCGTCAAGACCCATGTGATCGCCGCGGGCCGCCGTTCTTTCGGCCGGCCGACAAGGTGCAGTAGCAGCTCGGCTCCCGACTGTCCGCCGCCAACAACGCAGACATGCTTTTTTTGCACCTCAGGATTGATGTGGGCCAACTCAGATGAGTGGAACAGGTTGGGTCCAGTCCAGCCATGAAACTGAGGCGGAATTTGCGCCTGCTTGCCTATGTCGATGACGAGGTTTCTTGCATCAAGGACCGCGTTGTCCGTCCGCACGCGAAACTCGCCGTCAAAGCGGATTTCGCGAACGGCCTCGCCGCCACGGACAAGCGGATTCTTCTGGAACGCCCAGTTGAGATATTGGGCGAACTCGGCTCTAAGCACCCCGTGAAATTGCGCATTGAGGAAATTGTAAAGACGCCCGTTCTCGTGGAGGTAGTTTACGAATGTGTAGGCTGATCGCGGATTGACCAGAGTAACCAGATCCTGGAAGTGGCCGACCTGGAGCTCCGCGCAATCGAAAGCGCTGCCTGGATGTCCTCGGAAATCGACCTCCCGGTCCAGGAACAGTGCCCCTTGCGCAATCTCTTCCTGTATCTGACACGCAAGGCTCAAATTAGATGGTCCAGCACCCACACCAATACAAAAGAGGTCCACTTATCCTTACTCCTCTAGGAGTGTTTTCCAACTCAGCGGCATGTTGACGTCGATCGCCGGGCATTGAGCAATGCGAACCTCACAGGCATGCTTGAGCCGCGGTCCCGACTGAGAGGACAGCATAAGCGTGTGCCGCCTTCCAGGTCTTGGGCTCAATGTCGGCGGCATCGACAGCGGCGCGGCGTGATCCGAACCCAAGAGCAGAAGGAAAGTGTGTGATGCTGTCGCGCGGCTCTTCCGGATCTTACGGCGGCTTCTAGCGCCGGCCTCCACCCCAGGAGTGGCTGTTTCCCTGCCACGACGGAAGCGGCTCTTTCTTTCGAGGGGCGTAACCATGGATAATGGCTCTTAATGCTTTCGGAGACTCCCATGCATGCGGCGTGCCGGATAAAGACCCGTCAAACCAACGAGTTCGCGCAGTTCCAGCTCGTCTGGAATCCGACATTGTCGCACGCCCGACGATCGGGCAGGGGAAGCTCCGCGGCAGCGGCCCTTGCACACCGCAGGCTGACAGGGACAGCCGCCGATTTGACGCGCGTCCGGTCGCGTGGTGGCTGCCATGCAGCAAGATATCGAGACGGGCGCTTTGCGGCGGGGGAGCGCCTGCCGACCGAGCCCGAACTGGCTGCGAGCTTTGGCGTTAGCCGCTCAGTCATCCGGGAAGCCGTATCGCGCCTGAAAGCCGTTGGCGTCGGGTCAGCCGTCAGGGGTCCGGCGTGTTTGTCAGCGACGCCCCTTCTGCAGCGTTCTTTCAGGATACGGGGTGCCGAGGTCGGCAGCGGGATCGCTCTGCGCGAGATTCTCGAGCTACGGCTGTGCCTCGAAGTAGAGGAGCCGGGCTTGCGACAGCGGACATCAGAGCGTGTGATCGAGGAGTTCGTTCCAGCCTGGTCGCTGGCGCCGATCGTGCGGGCGCTGCAGACATTACGTGGTGTGGATCTGATCGTTGCCGTGACGTTTGCTACCCAGATTGGCGACGTGCGCCGTTTCGAAAGCCCGCGCCAGCTCATGGGCTATGTTGGCCTTGATCCTGGTGAGTGGTCGACCGGCGAGACAGTCAGACGGGGCGGTATCACCAGGGCAGGGAATCTCCGGCCAGCAACTTGCCATCCTCCAACCGCTTGGCGAACAAGCATACGCCCGTGCCGTCGAAATTGGCCCGGAGCACATAGACCGCGCCCGAGAAAGGCTATATGGCGCGCCACATAATCGTTCTTATGCGTCGGGCGAGATTTTGTGGCGGAGCCGCCCTGACCTGTTCGGGCCGGCCAAACCCAGCTTGCCTCCGCCACATAATATTCAGATGGAGTTCAGCAGTTGCAGAACGGAGTCCTTCGGGCGGAAAAGGCACGCCGTGATCGCCGTTGAGCCGGCCTTCTCCAGTCCATTGCGCATCATCTCGACATCCGCTGCGGGTAGTGGCGACCTGTGCGTGCCCGAGCCAGGCTTGGATCGTCAAAAGATCCACGCCAGACTGGACAAGCTTCATGGCGAGGGAGTGCCGGAAGATGTGCGGCGATATGGGCTTGACGGCCAAGACTGGCCTGGCAGGCACCGTCTTGGCCGCACGCCGCATGATATGGGTCGCTCCGAAACGGGTCAGGCGCTCGTTGCGGGCGCCGACGAATATCGGTCGCGGCTCGTGATGGGAGATCCCGCGCTCGCCCCACAAGGTCGTCAGCGCTCGCGCCAGGTCCTTAAGAATGGCCACGACGCGGTCTCTGCGCCCCTTGCCGCGCGGCAGCACTTGCGGGTGAGAGCGCTCCAATTGAAGGTCATTTGCGTTTACGCCGGTGCCTTCCGAGACCCGGGCGCCGGTCCGTGCCAGGAAGAGCAGAAAGGCTCGGTCGTGCCGACCACGAGGCGTCTTTGGGTCGGGCGCCGCGATGAGGGTATCTACTTCGGCCTTGGTGAGATGGTGCGTTACCTCGATGTGCGCCCGTTTAATGGTAATCGACAGCACGCGTTGGGCCACACCGAAGGACGCCGGATCGGCGGCAGCGACGTGGTGGAAAGAAGATCGGATCGCGGCCAAGCGGGCGTTGCGCGTGGCGACGCAATTGTTCCGCTTCTCCTCGAGTTCGTCGAGAAAAGCGAGAACGAGGTCTCGATCGAGATCTTCGAGCGCCAACGCCGCCGGCTTCTTACGCAACCGGTCGGCGGCAAAGAGGAGCATGCGCAAGGCGTCGCGATAGCTGGCCACGGCCGCGGGAGTCGCATTGCGCTGCTTCGTCAGGCGCCGGCGGAAATAGGACTCCAGGAGCGGCGCCAGGAGCAGGTGTTCGCTCATGCTGCGCCTCCATCGAGGGCGGCACGCTCAGCCGCGATAGCGAGGAGCTCCGCCGAGCCCGTGAGGTAGTAGGCCGTGTCGCTGTAACTAACGTGGCGAGATATGTGGCGAGCAAAGGCAATAACGCCTGAACGTCGGCGCGCTTGGTGCCAGAGGCTGAGGCGGGTCACGGCAAACCGGTGCCTGAGATCGTGCGGCCTTAACGGCTTACCGCAATCAAAGTCGGCGAGTTTACGGACCGCGGCAAAGCCGTTTTGCAGGCCGGTCGCCGAGAGGCAGTTGCCCCGGGAACTGAGGAAGAAGGCCTGATCCTTGGGTATTGGGAAAGCGGCGTCAAAGGCGGTCATGCGACGCCTCCCGGAAAGGGGAGTGAGACCTCGGCGAGCTGCGAGGTGGCGGCCTTTACGTACAATGCCGTTGTGCTTCGGTGCCCGAGAAGATCGGCGACCTCATTGATCGGCCTTCGCTGCTTGACGAGCTGGGTGGCAAGACTGTGGCGCAGGAGATGCGCACCTGCGACTCGCCCGAGTTCAACCCCGCCATGTCGCAACCGCTTCGGCACGATCCTCGAAACAGGCGACGCTCATTTGAATGCTGCCACTGGCGGCGTGAAGGACAGAAAAAGATTTGGACTATCCACCTTCGGTCGAGCGCGCAGGACATAGTCGGCGAGCGCGGCGCCGGTCTCCTCAAGCAGCGGCGCCACGAGATCCCGGTTGCCCTTGGTGCGCCCGACCGAAACCTCGCCAGCATGCCAGTCGATATCCTGCAGCTGAATTGCGCGTAGCTCACCGTTGCGAATGCCCGTCGTGGCGAGTAGCAGCAGGACGGCTCGATCGCGGATGTCGACCGGCGTCGTTGCGCCGATCGCATCGATTGCGCGCCGAAGGTACCCATGCAAGTCGCGGCGGCAAATGCGCCAAACGCCAATGAGGCGCCTTGGGACGACGCGGTCGAGATCCTGGTCATGGTGGCCAGCCCAACATAAAAACTGAAGAAATGTTCGGATGTGAGAAGTCGCCGCCGTGCGGGTGCCGGTGGTCGCCGATAGCGACACCCGCATCGCCCAACTCTACTACGTTGAGAGCGATGTTTTGGCCGCCGGCACGCCCAGCGCCATGCGCCGCCATCTTCTGCTGGCGGCGAGCGGCTCGGTGTCATCGAGGAACATGAAGTGGCCGCCTTGTCTTAGGCTCTTGATTCCTTGCAGCCCCTCGCTGGAACGACTTCGATCGATCCTCAAAGGGAGTTTGCGCCGCTGCCTTGATGAGTGGGAGCCGTTCGAAGCTTTTTCGATGCGTTCATCGACGCTGTATGACTGGCAGGCCCCAAGTATGGCGGGATGGACGTCTCCGACGCCAAGCGCCTGAAGGCTCTGGATGACGAGAACGCGAAGCTGTAGAAGCTGATCGCAGACCAGTCCATCGGTCCCATCTGTTTTGTCGGCGCGCATCGCTCTTGCCCGCTTGACGAACGTCTTGACATAGCACGGCGAGATCAACCGCACCTCGTGACCAAAGTGCTGCGATCTCGCGCGCCAGTAAGTTGACCACCGCAAATCGAGGCCGACCAGACAGGCAGGCTGCTTCTCGAAAAACCGCAGCACCTCGGCACGGCGGAGCTTCCGGTTGATGATTGAGAACCCGCAGCGTCAGCGCCGTGGATCTGGAATACCTGCTTGGCGATGTCCGGCCCGGTAGCGAATATGCAGGAGGCAAGCCCGTGACGGTCCGATACGTTGCGATAATATCATCGTCGCTGTGAACCGCCCCGGGTTTGCCGGAGGGTGGCTTCAGGGAACGGCTCCTACCTTGTGGCGTTGAAATGACGACCAGTATTTAGCACTCCGATGCTGCGGTTGCGGGCCGTTCCACTCCATCAAACGAGACACTGTTCGCTGATAGTTGTCAGCCTGGATGTTTTGCTCGACCGGCCCCTCGCGCCAGAGCCGTTTGGTGGGGCGTCGCTGCTGGGCCGTTTGGTCCCTTACCCAGCCAGCGGAACAGACGCAGACCCACATACCTCAATACCGACGAACACGCGGCCAGCGCCCACACTGTGGCGGTAATAGTTGTGCCCATCCACGCAGAATGGGGTTTATCTCCCGAAGCTTATCGCCAAGGCAGACGAGATGCTGCCCCGTCCCGTCAGTTGCTTGACCCTGCGACGCCACATCTCGACCGAAGCCACATTACGCACCAAATGTGTTCGAGCACATGGTGCGAAAATCCGCCCGCCCGGATCTGTGAGGGCGAAAGCCACGACCTCAGCCTGCCGGGAACGGAATCACTCGGCGAGACCCCTTCCGTGACCAATGTGGCCATATAAAATCAAGATGAACAGACGCTCGTATCTATATTGGACATTGGCGAACGCGTGCCTAGAGTTCGTGGGCGCTGGCCAAAATCATGACGCCCTTGGTCGCCTCTAAGCTGGTTCTAAAGCTAACGCAGGCAAATCGCCGGGAGAGTAATGCGAAATCTTAATTTCTCGGAAGCTGAGTACAAATCGCGCCTCCGTCGCGTGAAGGAACGCATGCTGACCGAGGGGGTAGATGTACTTGTCGTCACGGAGCCAGCCAACATCTACTATTTGAGTGGCTATGACGCATGGTCATTTTACACCGTGCAGGCCCTGATCGTCTTCCAAGAAGTGGAGACGCCTCTGTGGGTCGGACGGCTTATTGACTCGGCAACCGCGCATGTCACGACCTACCTACCAGCCGACCGCATTGTCCCGTATCCCGACGTCTACGTTCAGGCTGCGGATCGACACGCTGCGCAGTTTATCGCCGATATGATCCTTTGTGACTGTCCTAGCGCAAAAGTGGTGGGAGTTGAGATGGGTGCCTACTACTACACGGCTCGCGATCATGCGGAGCTGGTGAAGGCAATGCCGAACGTCCGCTTCAAGGATGTCGAACTTCTTGTGAACTGGGTCAGGTTCATAAAGAGCGAACAAGAAGTCGCGTACATGCGACAAGCTGGCGAAATCACTGAGCGCATGATGGCTCGCGCTGTTGAAGTCGCGGCCCCGGGTATTAGAGAGTGCGACGTGGCGGCAGCCATCTACCATGCCCAGATGTCGGGAACCGAATCGTGCGGCGGACTTCCCGCGACTAGCCCGCCTCATATGGGATTCGGTGCACGAGCCCGTGAAGCTCATCCGATTTTCAGCGATCGCCCTATCGATCCTAATTCCGTCGCCAATATCGAGATCTCCGGCTGTCGGCTGCGCTATCATGCCCCGATGAGTCGCACGATTTACTTTGGTGAGCCGCCTCAAAACTACCGTGACCTGGCCTCGCACGTCATAGAGGGTATCAACGCATCGCTTGACGTGATGCGGCCGGGGGCAACCTGCGAAATGATCGAGGCAGCATGGCGGAAAACGATGAGCGCTCACGGAATCGAAAAAGAGAGCCGGTTAGGATACTCGATCGGCGCGGCCTATACGCCAACATGGGGCGAGCGTACGGCTAGTATTCGTCGAGGAGATCGCACCGTTCTCCAGCCCGGGGTGGCACTCCACTTGATGGCGGGTCTCTGGCTTGAAGACACCGGTATAACGATCACCCAATCGTTGGTCGTTACGGGCAGAGGTTATGAGGCGCTCACTACAACCCCTCGTGAGCTCATTGTTAAGAACTAAGAAAATCAAGACGATAGTCTGCAGGACGTCACTGAGTATATCTCCGAGATTTACTGTGCAAGATGTTCGATATTCTGCAGAGTTCTGATTTTTGATGCGGCGACAGGATGCTCGTGAAGCAGGTAATAGCGCTCACCAGGTTCGAATGTGGCTGACCGGCTCCGGCGCGCCGGAACTGTCGCCGACCGTTGCCGCCGCACGCATGGTTGTGCTGCCAGGCGATCAGCCTAGTCTGACATAGAATGGAGTAGCAGTCATGAACAGTCACCTCAATTTCTACATCGAGGGCGCCTAGGTCTCGCCTGTCACGCCAGCCGCGCTCGACGTGATCGACCCCTCGACAGAGGAGGCCTGTACGCAAATTTTCCGTCGGCTCGAAGGCGCATGTCGACAAGGCCGTCGATGCTGCGAAGGCTGTGTTCCCGTCCTTCTCGCAGATCACCAAGGCCGAGCGGCTGACGCTGCTGCGCTGCAACCTGGAAATCTACGACGAGCGCTACGAGGACATCGCGCAGGCTGTTTCCTATGAGACGGGTACGCCGATCACATGGGCGCGCGAGGCGCAGGCCTGGGCCGGGCAGGCACATATGAAAGCGGCGATCAAGGCGCTTGAGGACTACGAGTTCTTTCGAGAAGCGCGGGACGATGATGATCGTCGGAGGCGATCGGCGTCTCTGCCCTGATCGCCCTCTGGAGCTGGCCGCTCAACCAGATCGTCTGCAAGGTGGCGCCCGCTCTCGCCGCCGGCTGCACAGTTGTGCTGAAGCCGACCGAGATCGCCCCGATCAGCCGCATTATCGTCGCCGAGATCATGCATGCCGCCGGCACGCCGAAGGGCGTGTTCAACTTGGTCAACGGCACCGGGCCGGATGTCGGACAGGTCATGGCGAGCCACCCCCACGTCGAGCGGCAATACAAAGCCAGCGTCGAAATTGTTGAGGCCGATCTGAACAGAGTCAATCTGAACCATCTCGCCGGCTAAGGATTACTATGATGAGAGGATTTCTAAAATGAGATTGAGCGAATATGTCAATTACGACGCTACCGGACTGGCACTCTAGTCTCAACAGGACAAGTAACCCCCGCGGAGTTGGCGCGGCTAGCCCGAGAGGCTCATGATGAGGTCAATCCTCGCATAAACGCCGTCATCGAGTTCTATGAAGATGCCGAAAACGTGCCTGGCGCGAGCGAGGGTCTTTTCCATGGCGTGCCTTTCCTTCGCAAGGATGCTGGTGAGACGGAAGCGCCGCCTTCAGGAACAAGGAAGCCGTCTGTTCCAAGGCTGTCGCGCTGAAATTGACAGCTATTTTTTTCAAAGCGCTCGGAAGAGCGGGCTCCGAACTATAGGAAGAACGGCCACACCGGAGCTTGGGATGTCTATAATGGGTGAAAGTATGATCAATGGCATCACCCGCAATCCCTGGAACCTTGAACGCTCTACAGGGGGCTCGTCTGCCGGAGCAGCCGCGGCGGTGGCCGTAGGTATCACGCCTATCGCCCACGGCAACGATGGCGGCGGGTCGATACGCATCCCAGCTGCTTGGTGCGGACTCGTCGGGCTAAGTCCGTCTCGCGGACGTGTTTCCGGCGGCCCATGCAACCAGGACGCATCATTTGGCCTATCGCGCGAGTTTGTTTTATGTCGAACCGTGCGTGATATGGCCGGCGCGCTCGATGCCTTTTCGGATCCCTATCCTGGCGATCCATTTATCATTGTCCGGCCGAACCGCTCCTATGTGGAGGAGCTTTCACAGCCTACCGGCACCCTGAGAGTGGGAGTGGCAAGGACCAAGTGGGGCGAGGTGGATTGTGAGCCGGAAGTCCTGAACGCCGTCGAATCGACGGCCGCCCTTCTCGAGGAAATGGGCCACAACGTCACCGACATCGAGCCGCCATATGAGCCGATCGAGTACTTGCGGAGTAACCTCGCCAAAACATTTTTTTTCGCGACTTCACTTGAAGAGACGGCGCGGACCTTGGGACGCCCGATCAACGCTGACACCTTAGAGCCCATCAACCTCAAACTTTATGAATACGGCCGGAATTCGCAGCGGCGTCCAGGGGACGCAGAAGAGGGCTACCGGAGAATGCGGCGCCGGGTGGGTGAGGCGATTCATGCCTTTGACATCCTGCTAACCCCCACAATGCCAATGGTAGCCCTACCGCACGGCGGCTTGAACAGTACGATCAACCCGACGCTGTCGGCGGAGGAATTCAAGGCAGCGGATGCTGCGCACATCCAGTACACAGGCGTATTTAATGTCTCTGGTCAGCCTGCCGTATCCTTGCCGTTGGCACAAAGCGCCAGCGGCCTCCCAATCGGGATTCAGATTGTCGGTCGCTTTGGGGATGAGGGCACACTGGTCCGTATCGCACGAGATCTGGAAGAAGCCAGACCTTGGAACAAACGGCGACCTAAGACTTGGGCAGGCGGCAAATGACAGTCACGCCGAAGAAGATGGGGGCTGACGACGGCCTCGTTCCCTCCCCTTATTCAAGGCCGCATAGCGGAATCGAGGACGAACGAGACAGGAGGCCGAAACGAGCTCCCGAGCGGAGCGACGCCCGAGGGAGGGAGTGGATGACGGCGCCAGATTGTGTAGCATGCGGCCGACCCAAATCGGCCGTCTGCCAAGCCGCTCCATACCCTGCTTATCCCATCAAGTGCCACGTGAGCACGAAGAGAATCCAGGCACCCGAAAGGGTCGAAAAAACTCACAAGCGAGCGGCCGCCCTTGATTCATTAGAGAACCCAAGCAGTTTCAGGAGAACCCCCGATCCAGGCTGTTGGCCTGCCGCGCCATGTTACCAGAGCCGGAGCTCGACATCACGGCTTGCGGCGTAATCGCTTTCGAACGAAGCCGCGATACGCATGGATGCGGTCGGGCGGTGGACTGCCGCACGCCGGCTGGTCTCTCGGCGGATGCGGCAGCGAGCGCGGTGGGTGTCTCACGCGCCTCACTCTTACCGCTGGGCGAAGCGGCCGAACCCTTCTCACGGTGGCCGCGACTGCCACGCCTGCCGCAATGGAGCGCAGCGCTGACGCAGAGCGTCGAAGAGCTTCGCGCTGACAACTCGATGTGGGGCAAGAAGAAGCTCGCCTGCCGTTGAGGCGGGAGGAAATTGCCGTCTCCGCCTCGAGGTCGGCCGCAGCCTCATGGCCAGCGGCCTCGTCACGCCGGTCCCGACATTCCGCCGAAAGCCCGGCGGCCGCCGCTTCCGCCTGATCGGCCTCGATCGTCATGCAACGCGCCTGCCCAAGGGCCTCAAGCCCACCATGCCCGAACAGACCTCGACACCGTCTTCGTCGACCTCGCCTCCGGCAGGGCTGTCAAGCACTTCACCGCCTACGACCCTGTCGCCCGAGCCATGAAGAATGACTTCCTCGTTCCTCAGTCTTTGTCGGCTTGTGGACGTGGATGTTCGATGACCCGGCTCGACATGACGCTGATGCGCCTCGCTCGGATGGTCAGGGGTGCATATGATTCTTGAGAAAAGAGGATTTGAAGAATGCCTTGCTGTGAGAGGGCATGAGCCCAAGCGACGGTGACCGGAGGCTCCTGCACAGCGCCGGTAATCAAAAGGTTGCAACAGATCCTCACGCCTTCGTGACAGAACGCCCAGGGGCAAAGAACCAGGTCGCTCGCGAATAGGACGGACTCGACCATGGCTCTCTAGTCAAAAGTTTTGCGCGGCGGTCCAGAAATTTGCGCTTATCTCAAAACGAGATGGGCGTAAGGCAAAAAAAATATTGGAGTGTCCGATGCATCGGTGACCATAGTTCGGGGTCGATGGCTGAGGCAATTGCTTTGGACCAAGGAGGCGAAGGGCGCAGAAGCAGGAGGAATGACGATGGTGCCGGGAGACGCTGCAGCTCAGATATGGCGAGTGCGGCCGTGCGGTCGCTGGGGAGGTCAAGCGTTGTGAGCCTCGCAAGATGATGTTCGTGCAAGCCTGAGGCCGCCTCAGGCACCTTTCGATCGGTACACCCTCTGCGGTGGCTAGCGTCGCAATCTAGGGATCACAACCATGGCTGTTGAAACCCCAGAACTTACTATTGTCCTCAACGACTATGCCGCCGAATCTTATGCGCGACTTATCAAAGAGCGTTTTCCGCAGGTGCGCACCTTAGTGGCGCCCGACTCCGACCGGCTGGAACGGTACATAGGCGAGGCGGATGCGCTGCTTGGCGCCCGCTTTCCCGTGGAGGTCTTCGACAAGGCGAAGAAGCTGCGCTGGTTCCAGTGCGCCAACGCTGGAATTGATACCATCTTTCCCATTCGCGATAGAGTGGGAGAGCTAATGGTTACCAATGCACGCGGCATCCACGGCGATGTCATTGCCGATCATGTGATGGCCGGCGTGACGATGCTGCATTGGGATTTCCGGCGATTTCTGCGGGAGCAGAATGATCGGCAATGGAGCCCACGATTTGTAGCGCCGCTGGCAGAAAAGACACTTGGCGTCGTCGGATTGGGATCGATTGGAGCGACCATCGCCCGGCGCGCCAAGAGTGCGGGTATGACGGTGGTTGGTTCAAAGCGGGACATCTCTTTGCCAGTCGAGGGTGTCGACCGGCTGTTCGCCTCCGACGCACTCGAGGATCTGCTGCCTCTTTGCGATTTCGTTGTCTTGGCACTACCGGGAACGCCGGAGACGGCGGGTGCCATCGAAGCAGCCGAGATCGGGCTCATCAGGCCCCATGCGTTTCTAAATCAATATCGCTCGAGGCAGCGTTGTGGTGGAGGCCGAACTCATCAAGGCGCTGCGGACCGGCGCGATCGCAGGTGCAATGCTTGACGTATTCGAGAAGGAGCCGCTGCCCGAGGACAACCCGCTTTGGGACATGCCAAACGTGATCGTCACACCGCATCTGGCGGGAAGTCCGACGAATTATGAGGATCGAGTGTTCTCCATCTTCGCGGATAATCTCGATCGTTTCATCAAGGGAGAGGCACTGATGAATGTCGTGGATCTGGGGCGCGGCTATTAACGGGGGAACTGGGCTGGCGTGGAGGGCGCTGTGCTGTTTTGCGACCGCTAGGTGCTTCGTCAGACACTGTCGAGGCTCATTCGGATGACGAAGGGCGACGTCGGCTTGCAGCCTTAGGCGAAGTCAATCGCTCGTAGCGATGATGGGAAGAACACCAAGAAAGGAAATGCCATGACTAAATCAATGGGACGTGGATTTTCGGCGTCAATCAGAGAAACGTCGGGGAGGATATAACACATGAGCAAGAACTATCGCACTCTTGATCAAATCAGGCGCAACCACTCCCCGCTCGAAAACCACCTGGTTGACGGCCTCGTTGATGGCCGGGTCAGCCGCCGCGACTTTATCCGCCATGGCAGCCTGCTCGGCCTGTCGCTGCCGCTGCTGAGCGGCATAGCCACGGTCGCGGGCTTCAGTGGCATGCCCTCGCTCGCTCGCGCGCAGGGCTCGCCTGGCGCCACCATTCGCGTCGCCGGCGACATGCCGGCGGCGACGATCGATCCTGTGACTATCTCCGACGGAGGTAGCTTTGTGCTATTAGGGCAGGTCGGAGAATACCTCTGCATCGCCGGTTCGGACCTCGTGCTGCAGCCGGCGTTGGCTGAAAGCTGGAAGCCGAACGACACCGGCACGATGTGGACCTTCAAGCTGCGGAAGGGCGTGAAATTCCACAGCGGCGGCGAGATGAAGGCCGACGACGTCGTGGCCAGCATCGACCGTCTCGCCGATCCGGCCAATTCATCCAACGCGCTGTCGGTGTTCCGCGGCCTATTGCAGAAGGGCGCGACAAAGAAGGTTGATGACTATACGGTCGAGTTCCACCTCGACGCGCCGAACGGCAACTTCCCCTACATGGTGTCGTCGGACAACTACAATGCCATTATCATCCCGGCGAGCTATAAGGGCGACTACGAGAAGAGCTTCGACGGTACCGGGCCGTTCAAGCTGGAGAAATACACGTCCAAGGTCGGCGCCTCCTTCGTTCGCAACGAAAATTACTGGGGCGACAAGGTGCTGCCGGAGCGCATCGAGTTCATATTCTTCTCCGATGATCAATCGGCTATCCTGGCGCTGCTTGGCGGTGAGGTCGATGTCATCTCACTTTCGGCGGCGGCCGGCGTTAGCCTACTCAACAACCCGAACGTCAATATCGACAGCGTGAAGACGGCCTCGCACTCGCAGTTCCACATGCGCTGCGATTCCGATCCGTTCAAGGATCCACGCGTGCGTCGCGCCGTGGCGCTCTGCCTTGATCGCGACAAGTTGGTTGCCGGCCTGTTTAAGGGCCGCGCTTCACCAGGCAACGACAGCCCGTTCGCTCCAGTCTACCCCTCGACTGACACGAGCGTGCCGCAGCGCAAGCAGGACTTCGCCCAGGCCAAGCAGTTAATGCAGGCGGCCGGCGTCGGCAAAGGATTCAAAGTGACCCTGACCACCGCGCGCTTCGTGGAGCTTCCCGACTATGCGCAGCTGATCCAGAATTGGGTTAAGGAGATCGGCATCGAGCTCCAACTCAACATGCTCCCCCTGGGCGCCTATTATGGCGATGCGGTGTTCGGCAAGTCGCCTTGGCTGGACTCGGTGATGGGCATCTGCGACTACGGCCATCGCGGCGCGCCGAACGTCCTGCTTTCCGCTCCGCTGACAAGCAACGGTAGCTGGAACGCCGCGCATTTCAAGAGCAAGGACTACGACACGCTGGTGTCCAGCTATATCGCGGCCCTAGATCTGGAGGCGCAGAAGGCAACGGCCGGCAAGATCCAGAACCTGCTTCTTGAGGAAACGCCTGTTATCTTCGGATACTTCTACGACGACCTGACGGTGACCGCGAAGGGCGTGTTCGGGATCAAGAAGACTGGCATGGGGCAGCTGTTCTTCGACAAAGCATCGAAGGCATGAGTCACAGCCAGCCCGTTGCGGGGCTGGCCCACAAGCTTATAACAGCCAGCTCCCTTGCGGGGGCTGGCTCCACGAGGAGTATTAGCTATTCTTTCCTTTCTCGTTAGGCGAGTCTCACTGTCGCTCGTCACGCTGTTCCTGCTCAGCATCATGGTGTTCCTGGGTGGCCAGGTGCTGCCCGGCAATGTCGGGCGGGCCATATTGGGTCCGCTTGCCGACCAGCGCGCCGTCGACACGCTCAATCACACGCTCGGCGTCGACCGTCCGCTGCTCACCCAATATGGCAGCTGGATCTGGAACTTCATCCAGGGCGACATGGGCACGTCCTATCTTTTCCGCTCGCCGGTGGCGCCCTTCGTCATCGATGCCTTGGGCAATTCGATGAAACTGGCGGCGGTCGCCTTCGTGCTGGTGGTGCCGATCGGCATCCTAGGCGGCGTCATCGCGGCGCTCAATCTCGACCGGCCGCTCGACCGCATCATCAGCCTTGGCGGCCTGTCGGTGACGGTGCTGCCCGAATTCGTCACCGGCATCATCCTGATCCTGATTTTCGGGGTCTGGCTGCGCTGGCTGCCGATTTCGGCCGCATGGCCGCGGGATGCCGGCTTGTTCACCCAACTCTATTACCTGATCCTGCCTTCGCTGCCGCTGTTCCTGGTGCTGTTCGGCTACATCGCCCGCATGGCGCGCTCCGGCATGATCGAGGCACTCGATGCCGACTATACACGAACAGCGGTGCTCAAGGGCCTGCCGTGGCGAACGGTGATCTGGCGCCATGTCCTGCGCAATGCGCTGCTGCCGACCATCACCGTCATCGCCACCCAGACCGGCTATCTCATCGGCGGCCTGGTGGTGATCGAGACGCTGTTCCGCTACCAGGGCATCGGCTCGCTGATCTTTACCGCGGCGCGGGGCAAGGATTTTCCGATCCTCGAAGCCGGCACCCTGACTATCGGCATCGTCTATGCGATCGCCACCCTGGCCGCCGACTTTCTCTACTGCGTGCTCAATCCGCGAATTCGGCTGGAGACAGACCAATGACCATCACCGACACGAGCATGCCGACGCCCGATGATACAGGCAGGCGCGGCTTGATGGCGGACGTGTTCTTTTCGCTGCTGCGGTCTGCTACTTTCCTCACCGGCTTCGCCATCGTCCTGTTCTGGATCTCCTGCGCGCTGTTCGGCGAGCATTTCGTCCCCTACGACCCACTGGCAACCGACATCATCAACGCGCTTGCGCCACCGTCTTCCGAACACTGGTTCGGTACCGACCAGATCGGCCGCGATGTCTACTCCCGCGTCATCGTCGGCTCGCGCGACATTCTGACCGTTGCGCCGCTGGCGACACTGCTGGCGACCGTGGCCGGCACCGCGCTCGGCCTGTTCACCGGCTATTTTCGCGGTCTCGTCGACGATGTCGTCAGCCGCCTTCTCGAAGCCTTCATGGCGATCCCCGGGGTCATCGTAGCGCTGCTGGCCATCGTGGCGCTCGGCACCTCCAAGACGATGGTTATCGTCGTCATTGGCCTCAGCTTCGCTCCAATCATCGCGCGCACCGTGCGCTCCGCCGTGCTGGCCGAGCGCGAACTCGACTATGTCGCGGCGGCACAGCTTCGACATGAAAGTGCCCTGCATACGATGTTCGTCGAGATCCTGCCGAACGTCATCCCGCCGATCCTGGTCGAAACTACCATGCGCCTCGGCTACTCGGTTTTCGCGGTCGCTACGCTCAGCTTCTTGGGGTTCGGGATCCAGCCGCCCTCGCCCGACTGGGGGCTCTCGATCTCCAACAATTACGGCATGATCAGCGGCGGCTTCTGGTGGACGGTGCTGTTCGACGCGCTGGCCATCGCCTCCCTGGTGATCGGCGTCAACCTGGCGGCCGACGGCGTTCATGGAGCGCTCAATGACTAGTTCCGCCAAGGCCAAAAACGCGCTCGAACTCAACGATCTGTCGGTGGCCTACCGTGTTGCCGGCCGCAACCGCGCCGTGCTCCGCAACCTCAGCCTCACCATCGGCCAGGGCGAAGCCTATGGACTGGTCGGCGAGTCCGGCTGCGGCAAATCCACGGTGGCGCTCACCGTCGTGCGCTATCTGCCGAGAAACGGCTCGATCACAGGCGGCGCCATCTCGCTCGACGGCCAGGACGTGATGAACCTGGATGCCGAGGCGCTCAGGCGGGCCCGCGCCGAGAGTGTCTCGATGGTCTACCAGGATCCGGGCAAGGCGCTGAACCCGTCGATCCGTGTCGGCCGGCAACTGACCGAAATTTTTGAACTCGGCGGCATAACGGGACAGGCGGCCATCGACAAGGCAATCGCCATGCTGAACCGGGTACGCATCTCCGATCCGGGCGGCGTCATGCAGCGTTATCCGCACCAGCTTTCCGGCGGAATGCAGCAACGCGTGGCGATAGCCATGGCGCTGGCCAACGATCCGACGATGCTGATCCTCGACGAGCCGACGACGGGCCTCGATGCGACGGTGGAAGCCGAAGTGCTCGACCTGATCGCGCAGCTCAGGCAGGAACTGTCGGCCTCGATCCTGTTCATCAGCCACAACCTCGCCGTCGTCTCCAACATGTGCGACCGCGTCGGCGTACTCTATGCCGGCATGCTGGTCGAGGAAGGACCGACGGAGGTCGTGTTCAGCGATCCGCGTCATCCCTATACCGTAGCACTCTTGCGCTGCCTGCCGCGCGGGGGCCAGCGCAAGCATCAGGGCCGCCTTGACACCATTCCGGGCTTCTTGCCCGGCATCGGGGTTGACATCAAGGGTTGCGCCTTTGCCGACCGCTGCGCGCTCGCAACCGACCGCTGCCGCAGCGAATTGCCGCCGCTCTACAACCTGAGTGACGATCGAGGCGTTCGGCTGTCGCGCTGTCACTATCACGAGCAGGCGCAATCCTTGCCGCGCGCGACGCAGAGGGATGTGGCACCGCTTGCGCCGAAGGCGACAGCTGTGCCGGTGCTGCGCGTCGCCGGGCTGAACAAGACCTATGGTAACGCCCTACGGGCGGTGAAGGACGTATCACTCACGCTGCGATCAGGCGAGACGCTCGGGCTAGTCGGCGAATCCGGCAGCGGCAAGACGACCTTCGCCAGGCTGCTGCTCGGCCTGGTGTCACCGGACGAAGGCGGCACGATCGAGCTGGAGGGCAAGCCGCTGGCGCCTAGGCTGGAGAACCGCAGCGACGACCAGATCAAGGCAATGCAGATCGTCTTCCAGAATCCGGACTCCGCACTCAACCGCTCGCATTCGGTCCGGTATCTGATCGGCCGCGCGCTGAAGCGGCTGGCGGGCCTCTCCGGCAAGGCGCTGGAGGCTCGCCTCAACGATCTCGTCCGTTCGGTGCGGCTGACCGACCGACATCTGACCGTCAAGCCGCGCCAGCTGTCGGGCGGACTGAAACAGCGTGTCGCCATCGCGCGCGCCTTCGCCGGCGACCCGCGGATCGTCGTCTGCGACGAGCCGACCTCGGCGCTCGACGTATCGGTGCAGGCGGCGATCCTCAATTTGCTTGCCGACCTGCAGTCGAAAGAAGACGTCAGCTACATCTTTATCTCGCATGACCTTGGCGTTGTGCGTTACCTCTCCGACAAGATCGCCGTGCTCTATCTCGGCCGCATCATGGAGATTGGACCATCCGAAAAAGTTTTCTCCGGCCCGCACCATCCCTATACCGAAGCGCTGCTGTCGGCCGTGCCCAAGCTCGATCACACCGAGATGTCACGCATTCGTCTTGACGGTGAGATCCCCAGCGCTACCCATCCGCCGTCGGGCTGCGTGTTTCACACACGCTGCCCGCGCAAGATCGGAGCGATCTGCGAAGAGCAGGAGCCGCCATTAGCCGAGGCACAGCCCGGACATTCGATCCGATGCCATATCCCCTATGCGGAGCTGGCCAAGCTCCAAAGCTCGAAGACCACAAAAGGCGGTTTTGTTGCAATGGCTGAATAGCGGCGCAGAGAAGCCTAATGCAAGGTCAATCAGGCGGCGAGGATTCGAACTGCTCGGCCCAGGACGGATTCGGATTGAAGGCATACCTCGCCTGTCGCTTGCGCAAGATGCCGGAAAGGATGGTGGAGGTGGCGGCCGTTGATTTGAAGCCGAGCATCGGCCGGCCTTGGCGCTTGATCCACCGATGGTCCTGCTCGATCAGATTGTTCAAATACTGGCTCCGGCGGACGCAGATCGGCTTCAACCGGCGCCAAGCGGATCCTGCAAGCGATTTGTGATGTCGCAGGAAACGCTCGCCTCGTAGTCGGCGGTCGGCCATGACGCTCCAGCGCCTTTCTGAAGAAGCACTTGACCGCCGGCAGGTCGCGCTGCTCTCTGAACCAAAACTCGACTGTGCCGACTGACGGCCTTTGAACACTGCAACCCTCCGAAAATGATCGAAGCCTCCTTGCCACAGCGCCGTATTCAAAAGGTTGCAAAGATCCTGCTGCTTTGCAGTGGAGCGAAGTCTAGAGTCACCCTGGTAAAACATAAGACGGGAGGGAGCTCGATGGGTGGAGACGAGTCCGGCGGTGGGATCACATCCACGGTCATATACCCGACGAATTTAATGCAAAGCAGCCGGAGCAAGAACCGTGACCAAGAACTAATCGCATTTCTAGTTGATTGCTAAACGGCTTGGCGTGCCTGCACCCAAAACAATCCTGTTCTATATCACATTGTGTGCGCGAGTGGGGGAATGGAGGCAGATTGCCTGCACAGCTCATAGATTACTGCGAACTTCGGATAAAGGAGATACAGTGGAACCCTGGGGATGGTGTGAGGAAACCTGGCGGCAAAGAGTTGGAAAGGTGCGCGCAGGGCGCTCGCTAAAGCCTGCCAGTTGGAAGGGAGGCGCGCGCTGTGCGGTGGCACTATCGTTCGACTGCGATCACGAAACTTCTGAACTGGTTCTTGGAGGAAATTCCATCGGCCGCCTATCGGCGGGCGAATATGGCTCGCGGGTTGGTGTGCCCCGTATCTTGAACACACTGAAACGGAATGGAATTTCCGCTACATTCTTCATCCCTGCTGTATCCGCTCTTTTGCATGAAGATGAAGCACGTCGCATCGTGGGAGATGGACATGAAATAGGCATCCACGGTTGGATCCACGAGTTCAACAGCATTCTTGCTCACGAGGTTGAGCGGGAGCTTCAGTGCAGGGCGGCTGATACACTGGAAAGAGTTTCTGGTCAGCGCCCCTTGGGAATGCGTACGCCATCGTGGGACTTTTCGCAACACACGCTGCAGATCGCACAGGAACTCGGTTTGATTTACGACTCTTCTCTCATGGCCGACGACGATCCGTACGAGTTGCTGGGAGACGGTGTGCCTACCGGTATCATTGAACTTCCGGTGGAATGGATCCGCGACGACGGCGTCTATTTCAATATGGATCTGCAATCTGCGCTGCGACCGCAGATGTCACCAATGGCAGTACTCGATGTCTTCAGGCGGGAATTTGACCAGGCTTGGGGAGAGGGGGGCCTCTTCCTGCTTACGATGCATCCTCATGTGATCGGCCACCGATCGCGCATGTTCATTCTTGAGGAGTTGATTGCCCATATAACGAGTCGCTCTGACGTTTGGGTCGCAACTCACGGTGATGTGGCTCGCTATTTGAAAGAGATGACCGCTACTCCGACACTCTAGACGTCATGTTCCGAGGCCTGAGATCGGTGGCCCGCCCTTTCGCGCGATTAAGAGACGAGGGTTGCTCGGTACGTCGAGCCGATCCTCACGCACGGAGGACGAGCCATGGGAGAGCATAGCGAAGCATTTGTCGCGTTTGATGTAGACCAGAAGAAGCATGCGGCGGCGATCGCGGAGGGCGGCCGCACGGGCGAGGTCCGGTTCGTCGGCGAGGCCGGCAGCGATAGAGCGGACGATCAAAAAGCTGAGAAAAAGGTACGATCGACTGCACGTCTGCTTCGAGGCCGGGCCGACTGGTTACGGACTTTACCGTCAGGTCCGCGATCTTGGTCACGACTGCATGGTGTTGCGCCCGCCCTGATTCCGAAGCTGTCGGGCGAGCGCGTCAAAACCAACCGACGGGACGCGGTCACTCTGGCGCGGCTGCATCGGGCGGGCGAACTGACCGAAGTGTGGGTGCCGGACATAGTCCACGAGGCTGTCCGCGATCTGATCCGGGCCCGGGAAGCAGCGGCAGACGACCTGCGCCGCAAACGCCAGCAGCTGCTTTCTTTCCTCCTGTGCCATGGCCGGATCTATGAGGACGGCGGTCATTGGACATTGGCGCACCGACGCTGGGCTTGCCCGCCAGAGCTTCGAGCATACGGCGCAGCAGATCGTGTTCCAGGAGAAAATCGACCGGGCGCGGTTCAGCGGCTACGCCGCCTGGACGGGCAGGTGAGCGCCATCGTGCCGAACTGGTCAACGGCGCGGGTCGTCGTCGAGGGCCTATCAGGCGATGCACGGCGCCTCATTCCTGGTGGCAGTGATCTTCGCGGCCGAGATCGGAGATGTGCGCCGCTTCGATACACCGGCACAGTTGATGGCCTTCCTCGGCCTGGTTCCGGGGGAGCGTTCGACCGGCGACACGGGCCGCATCGAGCCTTACACTCGTCGGCAATCGACGCGCCCGCCGCGCCTTGGTCGAAGCAGCATGGACTTACCGCTATCCCGCCAAGGTTAGCGAGGCCCTGAGGGTCCGGTCGCCTGGAAGGCGCAGGTACGGCTCTGCGCTCGCTATCGTCGCCTCAGCGCGTCTTCCGCAACTTCGCGTCGCCGACGTTCGGGCGCGGCTGGCACAGTGGCCAACCGAGGGATGATGCGGCCAGAGCGAGTTCACGATGCCGCAACTTGTTGGATGAACAGGAGCGGGACCGGTCTCATACAGACGGGCCGTGACGCTCGACTGATCGCGTCGGGCGGTATCGACGTCAGAATAAGCAAAGTGCCCCCGAGCAGAACACCGCACGAGTGGTTAAAACATTGATTTGAGGAAGCCTCAGCGTTGCGGGCCATCACGCTGGTGCCAGGAAGCGTCGACCCGATCACCATAGCCGCGCTCATGTCTGTTACCTTACCGCTCAGCACGAAGTCTGGGCTGAGAGCATGAATGAGACACCCGGAACCAACTCGGCCTTGGCAAGTACAAGACCAAATGTGAACTGCGCCTACGTGCTGTCGCACTGCTCGGATCGACCTTTCAGACGAACAATGAGCCTCGTCGCACGGGTCAGCTCTGCGGGGGACCCAGTGTGTGGAATTGCGTGGCAAGCCGACAGGGCCGAGTTCATTTACGAACGTGCCGACGAGCTCATCCGCTGTGGATGGCAAGGATGGGAGTTCGATGAAGTATGGCGGCGTGAGGTCTACTAGGCATTCCCTTCAAGCCGCAACGCGAACCAGAACGAGCACCCTTGCTACCCGCCTGGGCAATAGATGCCACAGCCGTCGCCGTGCTCCCGCCTTCTGGTCCGGTGGCACAAAGTCCTCAAGGTCGCGGATACTCGCGGCATCGCCGCTCCGCTCGACGTCGATCTGGAAAAGTGGATTCTTAGGGCGACGGCGTTCTTTAACGACAAGCCGGCCATCTCAAAACGCGATGTCACCACCTTAGACTTTATATTGGCGAACTCAATGCTAGGTGGCGCATACTTGGCGGGCAGCGGGTGGAGGTGCGTCCGCCCGCCAAGGCTCTAAATGAATCGAGCAATACAAAGTGCAGATCAAAGACGTCCTCCTCGCGCCTGGCAACGGCGCTTTTTTCTATGACGACCAAGCGTCCATCAGGCTTGGCGCAGTGCAGGAGGGCTTCATCTATGGTGGAGAACCGATAACGCCTGGGTTCACGTTGCTTCGCGTTCCGGCATCTTCGCTTAGTGTCTGGCTTGTTCTCACCGACGACACCGTCGTTTGGGGCGACATGATGAGCGTTCAGTATTCTGGCGCTGGCGGACGCGATCCTTTGGTCGACACCGCCCAAATCTCGGATTTGACGTCGCGGGTGGTGACGCCACGGCTTCGCGATGTCGATGAGTCTCTTTACCTTGATGCCTGCGCGAAGGTTTTTGAGCCATTCGAACAGGAGCGGCTACCCCTCGCGCTTGAGCATGGCGTCAGCCAGGCGCTCCTTCGCGCAGCGGCCCTACATCCAGCGGGCCACCATGGCAGAGGTTGTATGCGCAGATCTTTTTCAAACAGAGCCGAAAACAAAGCCTTATTATAGCGCTCATAGAGGAGTAAACAACATGCCAGCCACACCATATGAAGCCGCTATTGGCTACTCGTTTCCCCAGAGTGGCATGACTCGGGACGAGATCGAACAAGAACTAGAGCATCTGCGTTCACAAGATGCAGACCCGCGCTCGACGTTCCCAGATCGTTGGCTGAATGACCGCGGGCTCCTGCTTGATGACGGCACATTCGAAGTTGCCAAGGCCGCTCACTTTGCCTTTTTTACGAAGGGCAACAACTACCCTACCGTGGTTAAATTTGAACGCGATCTAATACAGATGGCGCTTAGTTTGTTCCACGCTGGAAAGGATGCAATCGGGGCCATCACCAGTGGCGGTTCTGAGAGTCTCTTTCTCGCTACTGCCGCTGCTCTAGCGAACGCCAAAGAAAGACGGCCTGACATCGCCAGACCAGAAATAGTCATTCCGCAGACGGGCTATCCCACATTCGAGAAATATGAACGGTATTTCGGATATACTATCCGTCGCGTTCCAGTGGATGAAAATTTTCGCGCAATCGTCTCGGCAATGTCTGAAGCAGTTAGCGAAAACACAGTCATGATGCTCGCCTCAATGCCGTCCTGGTCGCATGGCGTTTGTGACCCAGTTCGAGAATTAGCAGAAATTGCCAGCCAACACGGGATCTGGTTGCATGTGGATGCTTGCGTTGGCGGGTTTTTGGCGCCTTTTGTGCGGGAGCTCGGACGGGACGTTCCGGACTTCGATTTTCGACTCTCTGGTGTAAGCTCAATTTCGGCGGATTTTCACAAGTACGGCTATAGTGGCAAGGGAGTGTCGGGCGTTTTCTATAAAAATAAGGTAGCCCGCCATCAACCCTTCATTTTCGACACATGGGCAGCAGGACTTTATCGTTCACCAGTTCTCACTGGAACACGAAGCGGAGGCGCAATCGCTTCGGCCTGGGCAGTCATGCGTTATCTGGGGCGGGACGGTTACCTCTCTCGCGCTGCTCAAATCCTCAAGCTGAGAGATGCCATATTGGCCTTCGTTGCACAGTGCCCCGGCTTGAAGATAGTCGGCGGAGCTGAGCTTAACGTGGTGGGAATACGGAGCGAATACTCTGACATCTATTCAATTGCAAGCCGGATGAAGGAGTACGGGTGGAAGATAAATATACTAAAGGAGCCAGAGGCAATACAATTTGTACTTGGACCACTGCGAGATGAATATATAACCTTGCTGGTGAATGACCTTGAGAAGGTCGTTGAAGTTGTACGGCGTGAAGGGTTCAGAGTTCCTACGCCAGCCGTTGTCTATTCCGACGAATTCTTAGACTAACCGGGGATAATTAGCATAAGTTTATACGGTCGATTTCAATATGGAGAAGCCGACTGGGTACTTGAAAGGCCGCACGCCGATGTTGGTGGGATAATCCTCACCGCTGGCAGACTTAGACGCGGTGTGGCAGTCAGCCGGCCTCCTAGAGAGGGAGTCTGTTCTGTGGCGATCGATTTCTTCGTTTCTGCGATCGGCCCATCCTTGAACAAGACAATGCCCGCTAGAGCGCAAAGTTCTATCTCTGGTGGAATATACGGCGGCTCTTGGGCTCGCACCAATACGGGAGAAATTAAATGTCACTTTCTGAAGCAGTGCTAGCGAAGTTAAAAGACAAGTCGTTAGTGACGGATAAAGCTCTCGTAGGGGCTGGGTGGGTAGCGGCAGGTTCAAGGGGCCTCACGTTCGAGGTCACCAATCCCTCAACCGGCGAAGTCCTTGCAACCCTTCCAGATCTCGGTGAAGAGGAGGTCAAGTCGGCGATTGAGGCGGCCTATGTTGCCCAAAAGAACTGGGCGAAAAGGACGGGTAAGGAGCGCGCCGCAGTCCTGCGAAAACTGTACGACCTCATAGTATCGAATGTCGATGATCTTGCCACTATCCTCACCCTAGAGATGGGGAAACCATGGACGGAGGCGAAGGGAGAGATTCTTTATGGTGCATCCTACGTCGAGTGGTTCGGTGAGGAAGCAAAGCGAGTCTACGGCGACACCATTCCAGGTCATCAGCCGGATAAGCGCATCATCGTGATCAAGCAGCCCATCGGAGTTGTTGGGGCCATCACGCCGTGGAACTTCCCGAATGCAATGCTTGCCCGCAAGATGGCCCCGGCAATCGCTGCCGGCTGCAGCATGGTATCAAAGCCTGCGGCTCAGACGCCCCTATCCGCGCTCGCTCTGGCTGTCCTTGCCGAACGCGCCGGCCTGCCACTCGGTCTTTTTTCTGTGCTAACCACGACCGATGCCGCGATGGTCGGTCAGGAATTCTGCCGCAATGAGAAGATTCGGAAAGTCACGTTCACGGGCTCGACCAATGTCGGAAAAATACTGATGCGGCAAGGCGCAGAGCAGATCTTAAAGCTCGGCCTCGAGCTCGGAGGTAACGCGCCCTTCATCGTTTTCGATGACGCGGATCTCGACGCCGCCGCCGACGGCGCAATGGTTTCCAAATACCGCAATGCTGGGCAAACCTGCGTCTGTGCCAATCGGCTCTATATTCAGGAGGGCGTCTATGATGCCTTTGCCGCCAAGCTTGCCGAGCGCGTTCGCCAGATGAAAGTCGGCGACGGCTTTGCCGAAGGGGTCACGACAGGCCCTCTCATCGACCGGAATGCGCTGAAGAAGGTACAGGAGCACGTCACTGACGCCATCGCCAAGGGGGCTACAGTGGAGGTCGGTGGCAAGCCTGCGAGCCAAGGCGGCCTCTTTTTCGAGCCCACTATCTTGACCGGCGCAACGGGGGATATGCGCCTCTCGAGGGAAGAGACGTTCGGCCCTATCGCGCCGCTGTTCAAGTTTTCGACCGAGGAACAAGTGATAGAAATGGCGAACAACACCAAGTTTGGCCTCGCTTCATACTTCTATTCCAGAGATATCTCGAAGATCTTCCGGGTGGCGGAGGCTCTCGAGTGCGGCATGGTCGGGGTTAACACTGGGCTGATCTCCACGGAAGTTGCGCCTTTTGGTGGCATCAAGCAATCTGGCCTTGGCCGCGAAGGGTCAAAATACGGAATCGATGATTATACAGAGATGAAATACGTGTGCCTGAGCGTGTGATCCCTTGATGCCAAAAACCTGGATCGGGGGTTCTCCAGAAACCGGTTGTGTTGCAACTCCAGCTTCTAAACCCCCGAACCTTTCTCAAGGCCCTCCGTCTCACATCTATCTGATCCCGGTCAGCATGAGGACATGGACATCATTTCCGAGATCGATCTCGAAATGCGGTTTTGGGGAGGGAACGAGGCCGTCGTCAGCCCCCATCTTCTTCGGCGTGACTGTCATTTGCCGCCTGCCCAAGTCTTAGGTCGCCGTTTGTTCCAAGGTCTGGCTTCTTCCAGATCTCGTGCGATACGGACCAGTGTGCCCTCATCCCCAAAGCGACCGACAATCTGAATCCCGATTGGGAGGCCGCTGGCGCTTTGTGCCAACGGCAAGGATACGGCAGGCTGACCAGAGACATTAAATACGCCTGTGTACTGGATGTGCGCAGCATCCGCTGCCTTGAATTCCTCCGCCGACAGCGTCGGGTTGATCGTACTGTTCAAGCCGCCGTGCGGTAGGGCTACCATTGGCATTGTGGGGGTTAGCAGGATGTCAAAGGCATGAATCGCCTCACCCACCCGGCGCCGCATTCTCCGGTAGCCCTCTTCTGCGTCCCCTGGACGCCGCTGCGAATTCCGGCCGTATTCATAAAGTTTGAGGTTGATGGGCTCTAAGGTGTCAGCGTTGATCGGGCGTCCCAAGGTCCGCGCCGTCTCTTCAAGTGAAGTCGCGAAAAAAAATGTTTTGGCGAGGTTACTCCGCAAGTACTCGATCGGCTCATATGGCGGCTCGATGTCGGTGACGTTGTGGCCCATTTCCTCGAGAAGGGCGGCCGTCGATTCGACGGCATTCAGGACTTCCGGCTCACAATCCACCTCGCCCCACTTGGTCCTTGCCACTCCCACTCTCAGGGTGCCGGTAGGCTGTGAAAGCTCCTCCACATAGGAGCGGTTCGGCCGGACAATGATAAATGGATCGCCAGGATAGGGATCCGAAAAGGCATCGAGCGCGCCGGCCATATCACGCACGGTTCGACATAAAACAAACTCGCGCGATAGGCCAAATGATGCGTCCTGGTTGCATGGGCCGCCGGAAACACGTCCGCGAGACGGACTTAGCCCGACGAGTCCGCACCAAGCAGCTGGGATGCGTATCGACCCGCCGCCATCGTTGCCGTGGGCGATAGGCGTGATACCTACGGCCACCGCCGCGGCTGCTCCGGCAGACGAGCCCCCTGTAGAGCGTTCAAGGTTCCAGGGATTGTGGGTGATGCCATTGATCATACTTTCACCCATTATAGACATCCCAAGCTCCGGTGTGGCCGTTCTTCCTATAGTTCGGAGCCCGCTCTTCCGAGCGCTTTGAAAAAAATAGCTGTCAATTTCAGCGCGACAGCCTTGGAACAGACGGCTTCCTTGTTCCTGAAGGCGGCCCGCTTCCGTCTCACCAGCATCCTTGCGAAGGAAAGGCACGCCATGGAAGATCCCTCCATTCGCTCCGGCAACGGTCTCTGCATCTTCGTAAAATTCGACAACGGCATTGATGTGCGGATTTACCTTGTCGTGTGCCTCGCGCGCTAGCCGCGTCAATTCCAAAGGTGTAACTTCGCCCGAATGCACCAGAGAGGCCAAACCGGTGGCATCGTACTCTGCATATTCACTTACCCTCATTTGCATCTATCCTTTCTCCCTTGCCCCGTGTCAGCGAGGGGCATTGGCACGCACAGCGCGATTTTGGATTTTCAACCAGAGCAAAACCAAACTGGAAAACAGCGGTCGTTTTTCCGACGCTGCTACAGTGCAAATCTCGACTAGACGACAGCCACAATCATTTCCGAGTAATGCGGGGTCAAATACTGTTTTGCGATATGATCCATCTGAACGTCAGATGAACACCTGAACTACCGACTTTCGCGCCTGGAAGAATCGCGATGAGGGTCGTCACGGGGCAAGGCGTGGCGCTGACCGCTGCTTGGGCTGACTCGGTTTGCGGATTTCGGCACGCATCGCGGTCCTTTCTGGCGCAGCTTGGCAGGCTTCTCCTTCCATGCGTCCGGAATCTGCCCGCCTTGACGTCGGCCTTCTCGGCGTCGGTATTGCGCTGCTTCGGCGCTGCCACGATGGTGGCATCGACAATCTGGCCGCGCATCGCCAGATAGCCCGCCTTGGCGAGGTGTTTGTCGAAGCGCTCGAACAGGTTCTGGACCGCCTTGGCCTGCGTGAGGTGCTCGCGGAACAGCCAGACCGTCTTGGCGTCCGGCACGCGATCGCCGAGAACCCGGCCCGAGGAAGCGCATGAACGACAGCCGGTCCTGGATCTGGAACTCGGCCTGGTCGTCCGAGATCGTCGAGCGCGACGCCACGTCGGGCGACAGACGACACCGTCTCGCCCGGGAAGGAAGCTCAGAGGTGGCTGCGTTCGTCTGAACAGCTTGCGGGGTTTTGTAAGTGGATTCCGCCTCTGTCATGCCGCAACCGAGATTGGCTGCGACCCGTTGAAGTAGGCCTGATCCGGGGTTTGCGGGTCAAGCGATAGAAGGCCAGATACCGGACAAGGGCTGTCCGGGCCTCCGGCACGCTGGCATAGGCTTGCAAGTAGATCTCCTCGTATTTGATGGGTTCTCCATAGACACTCGACGAAGACGTTGTCGCGCCACGCGCCCTGGCCGTCCATGGAAATGGCGATTTCGGCATCCGCTCTAAGTTTATCTCAAAACGAGATAGCGTCGATCCGCAAACTGAATTTGACGTCGATCTCCGCGACCGATCATAGTTCGGATGCACGTTCTTCGCGGTATCTAGAAAAGGTTCTCAGCCTGTCGGTTCGCCGTTGATTTTCGGCACGAGAGGCTAGTGGTGAATAGTCAGTCGCCGCAAGGATTGGCCCCGGGATCCGACATGAAAATGAAGGAATCTATCGACCTATGGTGCCTCAGTTGGTGCTGCAGAATGATCAGCAGGGAAATTGAACACAATGAACCTTGACAGCGCAAAGGAGCTAGCCTCCGTCGTCTTTTCTGACAATTATTTCGAAGCGAGGCAGAAATTCCTGGCGGCGGCGCCGACGTCGCGAGCATACCGATGCAGGACAAACGGACCCTCTGGTGAGGCTCTCTACACGGACGCAGCATATTTTGGCCCGGCGGACGCCAAGAAACTCCTGGTTCTGGTTTCCGGCACGCACGGACCAGAAGGTTACATCGGTTCCGCGGCGCAACTTCTATTCTTGCGAGCTAAATTTCACGAGCGTCTCCCATCCTCCACGGCGGTGCTCTTCGTCCACGCGCTGAATTGCTACGGTTTTGCCTGGGATCGCCGAGTTACCGCGGAGGGGGTTGACCTCAACCGGAATTTTGTCGACTTTTCCAAACCGCTCCCCTCGAATCCTGGATACGAGGAGTTGGCTGAGCATTTTGTTCCCGCGGACATCTCCGAGGAGGGATTGAAGCGCGCTGAGGCTGCGTTCGCGGCATATCAAGCGCGCCACGGCGAATTGAAACTTCGGGAGGCGCGGGGATCGGGGCAGTACACCAATCCGGGCGGCCTGTTCTACGGCGGAACCGAGCCTACCGAAGCCAGGCGAACTCTCGAGGAAATAACGAAGGAATTCAACGTAGCGGCCCGCGATGAGGTCATCATCATAGATTACCACACCGGCCTCGGCCCTTACGGCTATGGGGAGCTGCAATGCGAGCAGTCGTCCGGACTGGGCGGTTATGAGCGAGCCATCAACATCTTTGGCCCGTCCGTAACGTCGCCGGAGGTAGGGAATTCTTCCGCCGAAATCATACCTGGGACCCAAGACGCTTTTTGGGAGCGTATCTTGGGGAGCCGGCACACCTACATTGCTCTTGAATTTGGAACGTACAAACTAAATACAGCGGTGCTGCGCGACGACCATTGGTTGTTCATGTATCAGCCAGAAGAGGCTGATTCCGAGCGGGGCCGACAGATCCGTCAGGTCGCCAAATTGCACTACTATCCGCAGGGGTCAGACTGGAAGGAGATGATCGCTTGGAGATCGCACCAGGTGCATCGACAGGCAATCGAGGCGCTTGCGTCAGGAGAATAGCGCCCCGAGCCCGTCCGGCGTCAGCGCCAATTGAGGCAATGTCGGCTTAACGCATAGAGGGCCTCAGAAAGAGCCGGCGCAGAGGGTCATCCAGTAAATCCGCCGCGCCACCGGGTCGGACCTTCCTGTATTTTCCTACTCGCTCCGGCGGGGCTCCTGCAACCAGCCCGGTGCTCCTTTCACGGCATCAATTCATCATATGACCATGTTACTAGGTGGCATTGACGTCATACTGCTGTTCTGTCAGCTTTCAAGTCAGAGGGGCGGAGCCTAGGACCCAGCCTGCCGTGCGGGCTGATAGGAGATCGGCAAGCAGGAGCAACGACGATCGGCGAGTCGAGGTAAGAAACATGGGTGATGAAATGGGACCTCGATTTTCGCGTTCCGGCTTGAACCGCCGGACACTGCTCCAGAGTGCGGCCGCCGCAATGATAATTCCGGCGGTCGCCCGGGCGACAACGGCCTTTGCACAAGACAAGCTCTCCGGCAGCGGCAAGGTTGTCGTGTTTTCGTTTGGCGGTTCATGGACTGAGGGCATGCGGAAGTACGTCTATGAACCCTTCACAAAGGCGACCGGAATCGCGGTGGTGGACGTCGCGGCCGATTTTTGCGAGCCGCAGGTCAAGGCGATGAACCAAGCTGGGCGGGTCGATTGGGACACGGCATATATCCAAGGGATGAATTATCCCGCCATGCATGAAGCAGGCACCTTCTTTGAGCCGATCGACTACAACTTCTGGGACGATGAGTCGCTTAAGGGCGTACCAGATTCACTTCGCCTCGAGGACGCGGTTGCCGCGATCGGATCGGCCATGCTGCTCGCCTATGATGAGCGCGTCTTCGGCGACAATGGCCCGAAGAACTGGGCGGACTTCTGGAACGTCGAGGCTTTCCCAGGCCCGCGCGGCCTTTATGCTCCAGTGCCTAAGCACAACCTTGAATTTGCCCTTTTGGCCGACGGCGTTGCCAAAGAGGACATCTGGCCGCTGACCGATGACAAGGTCGACAGGGCGCTCAAGAAGCTCGACGAGATCAAGCCGCACGTGACGAAATGGTGGACGGCTGGAGGTGAGTCCCCCCAGCTGCTCATCAACCGCGAATTCGTGATGAGCAACGCCTTCGACGGCAGCGTGATTGCGGCCATTCTCCAAGGGGCACCAATCCGGATGGTGTGGGAAGGTGCGCATGTGAACTACACTTACTGGGTGGTGCTCAAAGGAGGGCCGAACAGCGAGAACGCACAGAAGCTGATCGCATTCGTGAATCGGGCGACCATGGCAGCCGGCTTTACGGAGGGCACCGTGTTTCCCGGCCCCAACACAAACCAGCTCCAGCACCTGCCATCCGATCTGGTTCCTCTGCTCAGCATACACCCTGAGAATGCCCATCATGTGGTGCTAGAGGATTCAGCTTGGCTTGCAGCCACCCGCCCCGATGGCAAGACGAACATCGACCACCTACAGGAGCGTTGGCTGGCATGGCGGGCGGGCTGATCTCTCCCTCAGTGAACGGCGCGCCGGAGCCTGTACGGGCTCCGGCGTTGGGCGGGCCGACAGGTTGGGCTTGGCTCCTCCTGCCTGGAGGCGTTTACCTCACAGTGCTCTTTGTAGTTCCGCTCGCGGGGCTTTTGGTGATATCGCTCGGAATGCCGGATTGGACGCTGACGCATTACCTGCGCATCGGCGACAGCCCGGTCTATGCAGCCGTATTGCGCACGACGCTTGAAATCAGCCTGGCGGTGACCACGCTCGCCTTCGTGCTGGGGTACCCTATCGCCTACGCTCTGACGACAGGAGGACCAACGCTGCGCACGTTCCTGCTCATTGCAGTGGTGCTTCCCTATTTCACTAGCGTGCTGGCGCGGACATTCGCCTGGATCGTCCTTCTTGGGCGCGGTGGCATCGTCAACGAAATCCTGCTCCAACTTGGTCTGATCTCTCAACCGATTACCATGCTGTACAACCGCTTCGGCGTGATAATCGGCATGACCCACATCATCATGCCGCTCATGATCTTGCCGATGGCCACGGTCATGTCTGGGATCGACCAAAAGCTGTTGCGCGCCGCGAGAGCCAACGGCGCAAGCCCTTTGGCCGCGTTCCTCACGGTTTTCCTTCCGCTCAGCCTTCCGGGCGTCATCGCTGGGGTTCTGCTTGTCTTCATCTACTGCCTCGGCTTCTACATCACGCCGGCATTGCTCGGCGGTTTGGCTGATCTCACTATAACTATGGCGATCAGCACTCAGGTCGTAGACCAGCTCAACTGGAACTTCGGTTCCGCCCTTTCCGTGGTGCTCCTCGTGACCGTTTTGGTGATATTGTGGATCGGCTCGCGCTTATTCCCCATCCAGCAGCTTTTGGGGTTCTCCGATGGGATTGGGAGGGATGCTGCTGCCCGCCAAATGGGGGCGCGCTGGCTGATGCATGTCGGCTCCGCAGCAAATGCGCTCGACCGCTGGCTCCCGTCATTCGGCGGACGCGGCATACCCATCCTGGCGGTCATCCTCGCCACGCTTCTGCTGCTTCCCGTGCTGATTGTGGCCTATCTTTCGTTCAGCTCCTCGCCCTATTTCGTGTTCCCCGTGCCTGGCTACTCACTTCGTAACTACCAGGCTTATGCTTCCAGTGCTTCGTGGATAGAAGCGACCTTTACCAGCATCCGTGTTGCCCTGTTGGCGGCTGGCATGGCGACGGTCCTCGGCGCCATGCTCGCCCTCGGCCTCTCACGCGGTCGAATCCGCGGTCGCGGAGCGATGGTTGCGCTCGTGCTCTCGCCTATAATTATGCCGACTATTGTCGTGGCGGTTGCGACCTATTTCCTGCTGGTGCAGGTTGGGCTTCAGGGTACCGAGTTCGGACTGGCGCTTGGCCACGCGGTCCACGCAATCCCCTTCGTGGTCGTGATCGTGGTTGCCAATCTGCGCGACCTCAATCCGGCCTGCGAGCGTGCGGCCCGCAGTCTTGGTGCGGGGCCCTTAGCCACCTTCCGCACTATCCTCGCCCCGCTGATTATGCCGGCTCTCATCGTCGCCGCCTTCTTCGCCTTCCTGACCTCGTTCGACGACGTCATATACGTGCTGTTCCTTGGCATAGGCACGGTCAACACCTTGCCTATGCGTATGTGGGAAGGGATCAAACAGGACGTCAATCCGATCATTTCGGCGGTGGCTACGCTGCAGACGGCGCTCGCGGCGATCGTCATCATCGTAGGTGCCCTCCTGGGGCGTCGAAAGAATACGTGACGGCTAAGATTGAAAGCTCGCAGCAGAAAGAATAAGCAATGCTCACAGCCTCGCAACTGCTACCGTTGGACGCGATCGACCAACTGCCCTTCACCCCGGGAGAATTCGATGCCCGCCTTGCGGCTTGCCGGCGGGCAATGACCGAGCGCGGGCTCGACTACCTCGTGCTCAGTTCGCCCGAAAACATCTACTATCTCTCGGGCTTCATTACCAAAGGATACTACGTTTTTCAGGCGCTTGTCCTGACGCATACTAGCGATCCGATCCTCGTCGTGCGTCGCTACGAGCAAGCCAATGTCGAGCGTCTGTCCTATTACCGGAACGCTGCCATATGGCAAGACACGGATGTTCCGGCCGAGGTACTTGCAAGAGCGCTGGTCGATTTGGGCGCTTTGGGAAAGACCGTTGGCGTGGATGCCAACTCCATGTTCCTTACGGTGAACGCCTACGAAACGCTCCGCGCTGCGCTGCCCGGCACCAACTTTGTTAATGCTTCTACAATTCTGGAAAGATGCCGGGCCATCAAGTCCCCGCAGGAGATCGCTTACATTCGCCGCGCAGCTGAGACGTTGTCCGCAGGGTTCAAGGCCGCACATGAAGCTGCGCGTCCGGGGCGTACTGAGAACGATGTGGCCGCAGCTTTCCATCATGCTGCCATCTCGGCTGGTAGTGAATATATGGGCAGTGCCCCTTATATCGCTTCCGGCCCGCGAACGGCACTTCCGCACGCTACCTGGGCTGGCCGATGCATCGAAAAAGGCGATCTGGTCATCGTCGAGGGATCCGGAAACTGGAAGCGATACAGTGCAGCCTTGATGCGGACCTGGTGCCTGGGAAAACCGAGCGACAGCGTCCGTCGGGCAGCCGATACTTCAAAGGCCGCGCTCGCCGCGGCGATCGCGGCCATGAGGCCGGGCGTAACAAGTGGAGAAGTCGATGCTGCGTGTCGTGGCACTGTGGCTCGCGCTGGTCTCGCCCATGCCTTTCTCAATAGAACCGGCTACTCCGTGGGCGTTGGCATCTGCCCGGGCTGGGGTGAAGGATGGGTCATGGACCTAAAGGACGGAGATCCCCGCGTCCTGCACCCAGGCATGGTATTCCATATCGTGCCGGTGCTGTTCCCCGAGCCGAACATCAGCGTAGGCTTCAGCGCCACAGTGCTCGTCACCGAGACCGGCGCGGAGATTGTCTCTGATTACTCGCGGGAGCTGGAATGCTGAAAGCCATACACGACACTGCCGTCGTAAAGACGGGCGGCATCACGCTCCGCAGCTTGGGAAAACGGTACGGCAGCGCCGTCGCCGTCGACGACGTCAGCCTTGAAGTATTGCCCGGCGAATTCGTGTCGCTACTCGGCCCCAGCGGATCGGGCAAGACCACTACGCTGATGATGATCGCCGGCTTCACAGTTCCCGACAGCGGCCAGATTCTGCTGGACGGAAAAGACATAACCCGCCTGCCTTCGCATCGCCGTGAGCTCGGCGTCATTTTCCAGAACTATGCGCTCTTTCCCCACATGACGGTCGCCGAAAACGTGGCGTACCCTTTGCGTATGCGCCGCATGGGGAAGACAGCGGTCGAAAACAGCGTCAAACGGGTCCTCGAACAGGTGCAGCTTGGCGCACTGGCTGCCCGCTACCCCCACCAGCTATCGGGTGGTCAGCAACAACGCGTAGCAATTGGCCGCGCTTTGGTCTTCGATCCTCCCGTGCTGCTTCTGGACGAGCCTCTTGGGGCCTTGGACAAGAAGCTGCGCCAACATCTAAGGACGGAGATAAAGGCGCTGCACAAGGACGTCGGCAAGACGATGATCTACGTCACGCATGACCAGGAGGAGGCGCTGGCCATGTCCGATCGTGTTGCCGTTATGCATGAGGGCCGCATCAGGCAGGCCTCCTCACCGCGCGACATCTACAGGCGGCCCGCCGAGCTCTTCGTCGCGAGCTTTGTGGGTGAAGCGAACCTTGTTCCGGTAAAGCTTAAGGGCGGCGTCGCCTACAGTTCGGATGGGAGGCGTCTCGAGGCCACGCGATGGGATGGCGACGACATGGAAGCCATGCTTTGCATAAGACCGGAACACGTTCGTCTCGATTTGGGTGATGTCGGGATGGCTTCCGGCCCCCAGGGGACCGTTGTCGACTCCACTTATGTCGGCGACGCAACAGTCATTGAATGCGAAACGGACTCTGGGCTGCGGCTAACATCGAAAGTACTCAACCAGTCGGGCGACCAAATTCCGACTATCGGCTCGAGTTGCCGCGTGAGATGGGCCGCGACCGATGCAACGATTCTCACTAACTAGCCGAGTAAGCGACGGTGTTGCTCGCGCTACTGGTTGATGTTGATCCGTAGTTCCAAGGCTAGCACCGGCAAAATGCAAGAAAATCTCCCGTAAGTTCTAGCACGCTGGCCGCTGGTGTTTTTGGATGGGCCATCATGTTATTTCACTTCATCAGAAAGGTCTGCATATGGAAAAAATAACGCGCTACGAAGTTGGTCCTCGCATGAGCCAAATGACGGTTTTCGGTGACATGGTCTATACCGCGGGCATAGTGGCGCTGCGTGCCCCCGGAAGGCCAGTTGCTGACCAGACAGCCGACATTCTGGCCAAGATTGAGGATCTGTTGGCTGTAGCGGGAACAGAAAAGGGCAAGTTACTGACGGCAACGATCTGGCTGTCCGACATGTCTACATTCGCAGAGATGAACCGAGTATGGGACAATTGGGTGGTGCCGGGAAGAACACCTTGTCGGGCCTGCGTTGAGGCCGCGCTAGCAGGATCGGGATATACGGTCGAGATTCAGGTTACTGCGGCGCTTTAGGCTGAATGCGTCCGTACTCAAGCGCAAGGCCGTCGTCTATGTGCGTCAGTCCACTCAGGCGCAGGTCCAGCTCAACCTTGAGAGCCAGCGTCGGCAATATGAGCTTGTCGACGTCGCGCGGCGCTGGGGATTCCGCAAAGTAGAGGTGATCGACGAGGATCTGGGACGAACCGCAAGCGGGGCTGTGGAGCGTCCCGGTTTCGAGCGCCTGGTCGATGATTTGTGCACCGGCCATGTGGGCGCCGTGCTTTGCCGGGAGGCGTCCCGCCTGTCGCGCAACGGGCCGGACTGGCATCGGCTGCTCGAGTTGTGCGGCGAAGTCGATGCACGCGTGATCGATCTGGACGGAGTCTACGATCCGCGATTGCCGAACGACCGCCTGCTGCTCGGTATGAAGGGCAGCATCAGCGGGTTCGAGCTCGGCGTGCTGCGTGCCCGCATGTACGAGGCCGCCCGCGCCAAGGCACAGCGCGGAGAACTGCGCATCTCCGTGCCCTTCGGCTATGTCTGGCACCGCGATTACGGTCTCGGGTTCGATCCCGACAAGCGCCTGCAGGAGACCATTCGCCTGATATTCGCGCGCTTCCGCGAACTCGGCAGTGCGCGCCAGGTCCTGATCTCGATGATCGACGATGGCGTGCATTTCCCCAGACCCTCCGACGGCAAGAAGATGGTGTCCTTCGACTGGGTTCCGATCCGCTACCGCAACGTGATCTCGATCCTGAAGAACCCATTCTACGCCGGCGCCTATGTCTATGGTAGGAGCGAGAAGCGCACTGAGATCGTCGATGGCCGCGTTCGCAAGAGCTATGGCCATTACAAGCCGGCTAGCGAGTCGGCGGTGGTGCTCAAGGACCATCACGAAGGCTACATCGGATGGAGCGAGTACGAACGGAACCAGGAACTGCTCGCGGCCAACGCTTATGGCAAAGCCGGCGGTGTCAAGTCGGGCCGCGGCGGTCGCGCGCTGCTCCCGGGTCTCATCTCCTGTGGTCGATGCGGGCGAAGACTGGTTGTCATGTATGCCGGACGCGGCCAGGGTTATCCGGTATATCGCTGCGAGCGCGGCAACCTCATGATGGCACAGGCGCGATGCATGTCGTTCAACGGCTTTCGCACCGACGCGGCGGTGACCCGCGAAGCGCTGGAGGCGGTTGCGCCGATGGCGATCGAAGCGGCGTTGGAGGCTGAACGGATGCAGCTGGAGAGCGAAGCCAAGCGGCGGCAGATGATCGAGATGGACCTGCAGCAGGCGCGCTATGAGGCATCGCTCGCCGAGCGCCGCTATGCCGCTTGCGACCCGGAGAACCGGCTTATTGCGGCCCAGCTCGAGAGGAGTTGGGAAGCCACGCTCAGGCGCGTGGAGACCTGCGAGGCCCGGCTGAGCGAAGTCCAGCGTGTGGAGCCTGTCGACGCGGTTCCGGACTTCACGGGCCTCGCCCAGAATCTCGAGGCCATCTGGAACGCGCCGGGTGTCGATATGCGCTGCCGTCAGCAACTGCTGCGCGCGCTCATCAAGGACATTGTGGCGGACGTCGATGACGACGCGCGCGATGTGATCCTGACCATCCACTGGCACGGAGGCCAGCACTCGCAGGTACGGGTTCGCAAGCCCAAATCCGGAGAGCATGGCCAGCGTACGCCTGAGGAGGCTCTGGCGATCATGCGATCCATGGCAACCCGGTGGTCGGATGCCGAAATCGCTGCCACACTCAACCGCATGGGCATGCAAACCGGTCAGGGAAAGACCTGGACCGCGCGTCGCGTCCAATCGCTGCGCACGGTGCACAAGATCAGCGGCTATCGCTCTTCCGACAAGAATGGCGAGTGGCTCACCATGTCGGATGCCGCCGCGAAGCTCGGCGTGTCGCACGTCAAAATCCGCCGGTTCATCAGGGATGGCCTCTTGCCCGCCGAGCAGGTCATGCGCGGCGCGCCCTACCAGATCCGCGCCAGCGACCTCGAAGACGAACGGATCAAGGCCGATTTGGCGCGCAATACTCCGCGTCGCATCCACGACGACAACCAGGAATCGCTGTTTTCCGCCATTTGAAAAGGGGTGCATAATGAATCAGTCTTCGCAAAACCACGCAGCGCGCGTTCGGCCGCGTTGTTGGTGAGGCAAATCCGGCCATCGCCGAGGAAGGTCGTGAATCCTTCCCAGCGCTTCAGCATATAGTCGATTGGCTCGGCGACCGGAGAGCTGCGCGACAGTCTTGCCCGCTCTGCCCGCATCCAGGCCTCAAGTTCGGTGGCGAGAAGACGGCTTTCCTGCCGTCGTTGCAGACGTTCGTCGGAGACGACTCCGTTGATGTCGCGCTCGATACCAAACAGGGCGTCGATGCGTTTGACCGCCTCGAGCGCGATCGGTGAGATCGGCGCGGCGTTCTTGCCACGCTTGGCATTGGCGCGATGTCGGCAAGTACGAAGAACTTGCGGCGCGCATGCGCCCAGCACAGCGCCTGGGTCAGCGGACTGGGATCGCGGTCCACCTTGAACAGCGGATTGTAACCGCCATAGGCATCGGCCTGCAGAATGCCGGTGAAGTTCCTCAAATGACGCTCGGGATGCTCCTGCCGCCGATCGCCCGAAGCATAAGTAGAGCGCCGCCGGTGGCGATTGCCCGCCGAACGCCGGTCATCCCTGACATAGGTCCAGATGCGGCCTGTATCGATCTTGCCCTTCGCCAGGATCGGCACGGTCGTGTCGTCGGCATGGAGACGATCAGCGGCAAGCACATGCGCCTCGATCAGCGCGTGCACCGGCTTCAGCGCCACGGCACAAGCGCCGACCTGGTCCGCAAGCGCCGACAGGCTGAGTTCGACGCCCTCGCGGGCATAGCGCTCGCTCTGCCGGTTCAGCGGTTGATGCTGGGCGAACTTCTCGAACAGGACCATCGCCAAAAGGTTCGGTCCGGCAAAGCCGCGCGGCGTCACATGGAAGGGCGCCGGCGGCTGCGAGATCTTCTCGCATTCGCGGCAGGTGAACTTCTCGCGCACGGTCTGGATCACTTCCACTGGCGCGGGATCACCTCCAGCGTCTCGGTAATGTCCTCGCCAAGCTTGGCCAGCCTGCCCGAGCCGCAGCACGGGCAGTTCCGGGGTGCGGCGATGACCACGCGCTCACGTGGCAGATGGTCGGGAAAGGGCTTGCGCGACGGGCGCTTGCGCTCGAAAGCTCGGACTGTCGATGACCGCGCTGTCAGTTCCGCCGCCAATTCGTCCTGGCTGGCGTCGGCTTCCAACTCCTCAAGTTGCAATTCCATCTGTTGGAGAAGCCTCGCCTTGCGTTCGGAGCGGCTGCCATGGATCTCGCGCTTCAGCTTCTCTATCTCCAGCCTGAGCCGCGCGATCAGCACATCGGAGTGCGAGTTCAAGGCTTGCGCGCGAGCGGCGAGCGCTTGCGCCTCACGGCGGGTCGCACGCTCGGCGAGGATCATCGCGTGCGCACTGGCAAGGTCACCGGGAAGCTGATCGGCCACATCAGTCATGGCGCGATGGAATCATATTCGCTCCCGCCAAGCCAGCGGTTTTGCTCATCCCGCCGAGCTCGGGCGCCAGGTTTTTTGCGGCATCCGCCAGTCGATGCCTTCTAGCAAATAGCCGAGCTGCGCGGGCGTGATCACCACCGTGCCATCGGCCGATGGCCAGATGAACCGGCCACGCTCGAGCTTCTTCGTGAACAGGCAGGCACCCTGGCCGTCATGCCAGATCACCTTGATCAAGCCACCCTGCCGCCCGCGGAAACAGAACAGGTGACCGGTGTGCGGATCGCGCTTCAATGTCTCCTGCACCATTAGCGACAGGCCGGGGAAGCCCTTGCGCATATCCGTATAGCCAGTGGCGAGCCAGACCTTCACACCGTTCGGGACCGGGATCATCGCCGCTCCAGCACATCCAGGATCCGGCCGAGCGCCTCGTTATCGATATCACTCTCGACCCGCAGGCGGCGGGCGCCGCCAAGCTCGATCGTCACCATGCTGCTCTTCTTGCGCGGTCTGGAGATCGGCGGTGGCTGCGCTGGCGATTGCGCGCTGGCAGCGCCTCGACGACTTCCACGGCAACGAGTTGCGGCACGGACGGCGCGGAGATCTGGCAGAGTTCCTTGCGCCACCGGAAAAGCTGGCTCACATGAATGCCAGCCGATCGCGCGGTCTCGGAAACACTAGCCCCAGGCTCAAACGTCGCCGCGACCAGCCGCTCCTTCTCCTCCCGAGACCAGCGCCGGCGCCGCTCGACCGACGTGATCACTTCAATCTGATGCTTCGTCACAGGGCTACTCCTAGTGCTTCCACTAGGACTTGCAGCCTTCAGCCTACCTCAGCAAGACGGCCGTGACCGCGGGGATACCCGAAGCCTTGCGCATCGCCAATCCATATCCGGCTGCTACTGCAGGCTGCGGGGGCAGGTCGTACCCAAGGACTCGGTTTAAGCCGTTCCGTCAGCGGCTAAAGGATCAGGGGCTAAGACAGCATCACCACTTCTTTTCCCTCCATGACGCCGAGCCGCATCGCAGCCTGCAGAAGGTGGCGGCGCATGGCACTACGTGCGTCAGCGGCCGAACCGGCATCGATGGCATGAAAGATGTCGCGGTGTTCACCGATGACACCATCGACGTGCGCCGGCCCTCGTTGCTTCAGAGTATTAATGCGGGCGATCGTCACGCTTTGGTTGAGCAGCAGGGACAGGTAACGCTGGAAGTCCGCGACCTTGCCATTGCCGCTTGCTGCCGCGACAGCACGGTGAAACTCGATGTCTGCGGCGACGCCCACATCCTGGCCGAGCTTGGTGCGATCCATCTCCTCTAGCCAGTGCCTGAGCGCGACGAGATCGGCTTGCGAACGGCGGATCGAGGCAAGCCCGGCTCCCTCCACTTCGAGGCACAGGCGCAGCTCGAAGATCTCGCGCAGAGCAACGCCACTGCCGACCTCGGCGTCCCGGATTCGGAAGGAACGCTGCAGGGGAGCATCGCTAACAAAGACCCCGGCCCCCTGACGGCTGACCAAGATCCCATCTGCCTTCAGGCGGGAGACCGCTTCCCGGATGACTGTACGGCTGACACCAAAGCTGGCGGCGAGTTCGGGCTCGGTTGGCAGGCGTCCCCCCGCTACAAAACGCCCAGTTTCGATATCCTCCTGCAGTGCAGCCACCACCCGATCGGCCAAAGGTAGCGGTCGTCCGATCCGTCTGTCCGGCTCGCCTTCAGGGCCATTGGATTCCGCGGTCGTGCGCATCCGATCGTTGATGGCCAAACACACCTCCTCTTCAGCTTTCGGGCAAGACCTTGCCCGGATTCAGAATGTTATGGGGATCAATTGTCCGCTTCAAAGCACTCATCAGTGCGATATCCACTTCGCCCTTATGACGCCGCAAACTGGCAATGCGCATCTGGCCGATGCCGTGTTCCGCGCTGAAGCTACCACGGCGTTCCATGGCAACATCCTCCACAGCGAGGGTGATAGCATCGTACAGCGGACCGATATCCGCAACGCTACACCCTTCAGGGGGGCGGATATTCACGTGAAGGTTGCCGTCTCCGAGATGGCCGAAGATATTTGGACGGCAGTCCGGAAAGCGAGTTCGAACCATATCCTCGATGGCAGCCACGGTTTCGGGGATCAAGTCGATCGGTACCGCTATATCGTGCTTGACGGCGCCACCAGCGGCGAGTTCCGCCTCAGAGACCTCCTCGCGCAGACGCAGGAGTTGACTGCGCTCCCTTCCGCTCTGGGCAATGACGGCGTCTTGGGCCACACCGATAGAAAGCGCCTTCTCCAGCAGGCTTTCCATCACCGCGGCGAGCGAGTCCTCAGCGTTCGGCGAAGACATTTCGAGCAAAAGATAAGCCGACGCCTCGAAAGGGGGGCGAGCGTCGGGAACATGTCGCGACACCAACTGCATCGCCTCGCCCGCAATGAACTCGCACAACGTCAATGCACTACCGACGCGGCTGCGGGCGATTTGGAAAAGGTCTAGTGCGCGGCCGACGCACGATACACCGACCAGCGCCGTCACTCGCTGAGACACCTTAGGTAGAAGCTTGAGGGACGCAGCTGTAATGATGCCAAGCGTACCTTCGGATCCGATGAAGAGCTGTTTGAGATCAAAACCGGTATTGTCCTTACGCAATGTCCTGAGGCCATCCCATACGCGCCCATCTGGCAATACCACCTCGAGTCCTAACACCAAAGCGCGCATCGATCCATAGGCCAGCACCTGCAGACCTCCCGCATTTGTGGCGACCGCTCCGCCAATCTGGGCAGAGCCCTCCGCAGCGAGGCTGAGCGGAAAAAGGCGACCGGCCTCAGCCGCGGCTTCCTGCACGCTCGCGAGCGTTGCGCCCGCCTCCACAGTCACACTGTCACCAACGGTATCCATCGCCCGTATCGCTTTCATACGGCGTAGCGACAAAATCACCTGGGGTACCCCCGCGACCGGTACCCCGCCAGCAACCAGCCCGGTGTTCCCCCCTTGTGGCACCACTGCTACGCCCGCCTCGGCGCACAGCCGCAGGCATGACGCCACCTCGGCCGTGCTGGAAGGCTGAAGCACACACAACGCGGAATTGGAGCGCAGGCGGCGCCAGTCGGTTTCGAACGCCGCCCGATCAGATGAATTGTAGAGCAACGCCCCGGGCGAGAGGACCTCTCTGAGGCGCGCCACTAAGGAGTCGTTGCCAGACGTTGCGGAGGTTACTTTCATCATATGACCATGTGACTTGGTGATGTTGACATACTATCAACAGTGTGCAATTTTTATCCTGGGTTGGCAAGTGACAGCGCGCGGCCTGGGTCACACACATGTCGTGGACCTCAGACGCGGCTACTGACCGTGAAACTCAGCAGGCGAAGTCGACCAGATGCGATCGTGGGTTCGTTGCCATCGTGAATATAGTTAAACGGCGGAGACCTTGGCTTTGAACAGTAATTTCCCTGGTGGTCGCAAAGTGGCGCCATCGCTAACCGATCGGCTGGAAACGGGAGACCTCCTCGTTTCAGTGGAGTCCTCTTTTTCAGCGACCTACCGGGAGGCTCGCGGGAAGTTCCTCGCTGCGTTGCCTAAGGCGCGCGCCTATGTTCTGCCTCATCTGACGGGGCCAGATGGGGAAGAACTTGCGGTGGATGTCGCGTGGCTTGGCGATCCAGATGCCGAATGCGTCTTAGTCACTATTTCGGGCACGCACGGGCCCGAAGGTTATTGCGGATCGGGCATTCAAATGGACTGGCTTGCACTGATCGCAGATGCGAGCCTTCCTGCGGGGGTGGCCTTTCTCCTCGTCCACGGCCTCAATCCCCACGGTATCGCCTGGGACCGTCGGGTAACGCAGGAGGGCTGCGATTTAAACCGTAACTTTGTCGATTTCGCCGCTGGCACACCTTCAAATCCAGGCTACGAAGAACTGCGGTCGCAATTCGTGCCGGCAGCTCTGGAAGGGCCAGTCTTCGAGGCCGCACAGAAAGCCATCCGAGTGTTCAAGGCCGCGCATGGCGAGCGGGCCTTCCAGGTCGCCCGAAAGGCTGGGCAATATGTAGATCCTGACGGGATGTTCTTCGGCGGGTTCGAGCCAGCCTGGTCCGCTCGTACGCTGGATGCCATCGCCCACGACTACGCACTGAACACGCGCAAATTCGTTGCGGTCCTCAACGTCCATACGGGTCTTGGACCTTACGGTTACGGCGAGCTACAGAGCGAGCATCTGTCGGCCATTGCCTCGCACAACATTGCAGAGAGCATGTTTGGTCCCAGCGTCACCTCGGCCGATCTTGGAACATCCAGTTCAATTCCGATCGAAGGCACGCTCCAGCTCTATTGGGAACGGTTGATCGGCGACGGCCAATATCTCGATCTCGCCTTGGAATATGGCACTTATGACATCGAAGCCGCGCAGCGCGTGTTGCTGGCAACCAGTGGCTTCACGCGCATGGCGGCGGTGACCGAACCAGCTTGTTCGGTCGCGAGGTGCGGAGGCGCTGCGTGCACATTTCTGTCCGCATGACCCGGCGTGGAGGGAGGCGGTGCTGTTTCGCGGCCGCCAAGTGTTGCGGCAGGCGCTGTTGGGGCTTACTCGAAGGGCGTCGTCGGTTCGCAGCCTTAGGCGGACCAATCGCTCACAGCTGTTGATGGGGAACCAGAAAAGGTTATGCCATGTCTAGATCAACGAACCATGGATCTCCGCGGTCCGGCTTGAGTCGTCGGACCCTGCTCCAGACGGCGGCAGCCGCGATGGCCGTCCCGGCGATTGCTCGGGCAACCACCGCCTTCGCACAGGACAAGCTCGCCGGAAGTGGTGAGGTCGTCGTGTTTTCTTTTGGCGGTTCGTTCACGGAAGGTTTTCGCAAACGGGTCTTAGAGCCTTTCAGCGAGGTGACCGGCATCAAGGTGGTCGACGTGACGGCCGATTTCTCCGAGCCGCAGGTCAAGGCAATGAACGAAGCTGGGCGGGTCGATTGGGACACAGCGTTCGTTCAGGGGCAGGCATATCCCCCTATGAGTCAGGCCGGCATGTTTGAGCCGATCGACTACACTCTGTGGGACGACGAGTCGCTTACGGGCGTCCCGGATTCCGCCCGCCTTGCCGATGCGGTCGCCGCGTTTCAGTCAGGTCAATTGCTCACCTATGATGAGAGAACATTCGGAGAAGATGGACCCAAGAGCTGGGTCGATTTCTGGAACGTGGAGGCATTCCCTGGGCCACGCGGCCTTTATGCCTCCGCCGCCAAGTTCAGTATAATATTCGCCCTTTTGGCCGATGGCGTCGCGAAATCGGACATTTGGCCGCTGACCGATGACAAGGTCGACCGGGCGCTGAAGAAACTCGACGAGATCAAGCCGCATGTAACGAAATGGTGGTCCGCTGGCGGTGAGCCCCCCCAGCTGCTCATCAATCGCGAATATGTAATAACCAGCGCTTTCGCTAACCGCGCGATTGTGGCGATCCGTGGTCAGGATGCCCCCATCCGCATGGTTTGGGGTGCCGGTGCGCCGTTCAACCGCACGTACTGGACCGTACTGAAAGGAGGCCCGAATACCCAGAACGCACAGAAGCTGGTCGCTTTTGCGAACAGGGCCGCAATCGCTGCTGGGTTTACCGAAGGGGTGGGAGTTGATACCCTAAATGTCAACCAACTCCAGCACCTGCCATCCGATCTGGTTCCTCTGCTCAGCATACACCCTGAGAATGCCCATCATGTGGTGCTAGAGGATTCAGCTTGGCTTGCAGCCACCCGCCCCGATGGCAAGACGAACATCGACCACCTACAGGAGCGTTGGCTGGCATGGCGGGCGGGCTGATCTCTCCCTCAGTGAACGGCGCGCCGGAGCCTGTACGGGCTCCGGCGTTGGGCGGGCCGACAGGTTGGGCTTGGCTCCTCCTGCCTGGAGGCGTTTACCTCACAGTGCTCTTTGTAGTTCCGCTCGCGGGGCTTTTGGTGATATCGCTCGGAATGCCGGATTGGACGCTGACGCATTACCTGCGCATCGGCGACAGCCCGGTCTATGCAGCCGTATTGCGCACGACGCTTGAAATCAGCCTGGCGGTGACCACGCTCGCCTTCGTGCTGGGGTACCCTATCGCCTACGCTCTGACGACAGGAGGACCAACGCTGCGCACGTTCCTGCTCATTGCAGTGGTGCTTCCCTATTTCACTAGCGTGCTGGCGCGGACATTCGCCTGGATCGTCCTTCTTGGGCGCGGTGGCATCGTCAACGAATGCCGCTCATGATCTTGCCGATGGCCACAGTCATGTCTGGGATCGACCAAAAGCTGTTGCGCGCCGTGAGAGCCAACGGCGCAAGCCCTTTGGCCGCCTTCCTCACGGTTTTCCTTCCGCTCAGCCTTCCGGGCGTCATCGCTGGGGTTCTGCTTGTCTTCATCTACTGCCTCGGCTTCTACACGCTTCTGCTGACATTACATGTTGCAGCTGGCCAATCCGGATTGGGATCGCCGCAGGCCATGAGAGTTTAAGATGGTTCAGTCGCTCGGGCATTCGCGGTTATTATAGCTGGCTTCTGTTGGAGGCCAAGAATCAGTCGAGCTAAACAAGTTCCAAAATCGAGAAGGACTTACTATGGAAATCCAAGGGCCGACAGTTGTTATAAGTGGGGAGTCGGCGAAGGCTTATGCGGAACTAGTAAAGGATCGCTTTCCGGACCTGCGCGTTATTCAAGCGCCCGACGCCTCAAGTCTCGAAAAACATATAGCAGAAGCGGAAGTACTACTCGGGTTCCGGTTTCCAGTGGAGGTCTTTGATAAGGCGTCGAAGCTTCGCTGGTTCCAGTCCACCGGCGCGGGCGTCGACTCGCTGTTTCCCATCCGGGACCGCATAGGCCATATCACTGTCACCAACGCCCGCGGTATTCATGGCGAAGTCATCGCGGACTATGTCATGGCCGCTGTGACTATGTTGCATTGGGACTTCCGCGGCTTCCTGCATGACCAAGCCAACAAGCGCTGGAGGCCACGGCCTGTATCGCCGCTTTCCGACAAGACCATCGGCGTCGTGGGTCTCGGATCCATAGGCGCAACAATCGCGCGCCGCGCCAAGAGCGCGGGTATGATAGTTCTCGGCTCGAAGCGGGATGTTACTGTTCCGGTCGATGGTGTGGACGAACTGTTCGCGCCTGATGGCATGGTCGACATGTTGCCGCGTTGCGACTTCGTCGTTTTGGCACTGCCTGCAACACCCGATACCGTGGGCTTCTTTGGGCCCGCCGAGATTGCTTGCATGCGCCCGGACGCATACCTCATCAATATCGCGAGAGGGAGCGTCATCGTTGAAGCGGAGTTGATTAAGGCTCTGCAAAGGGGGGCCATTGCCGGCGCCATGCTTGACGTCTTCGAGCAGGAGCCGCTACCGCCTACAAGTCCCCTCTGGACGATGCCGAACGTGATCGTCACGCCTCATACAGCGGGCTATCCGGCCAACTACGAGACGCGGTCTTTTTCGGTGTTTGCCGACAACCTGAAGCGATACATGGGTGGCCAGGAGCTGATGAACATCGTCGATATGAAACGCGGATACTAAGGTCAGTTGGCGCCAGAAATTCAAGTTACCCGCCGCAGGTCATCGCCAATGCAGTCTGGCTCTACTGCAGGTTCCCCTTGCTGCTGGAGCGCGGGATCGTGGTTTCGTATGAGACAATCCGCCGGTGGGGCATCAAGTTCGGTCCGGATTTCGCTCGCCGCTTGCGCCGCAAGCAGCACAGCCGAAACGATGTCTGGCACCTGGACGAGGTCGTCATCACCATCGCCGGCAGGAAACACTGGTTGTGGCGCGCCGTCGACCGGGATGGCAATGTGCTCGACGCGATCGTCCAGAACCGCCGCAACACCAAAGCGGTCAAGCGCTTGCTAACGCGGCTGCTGAAGAAGCAAGGCGTCGCGCCGAAGCGCATGATCACCGACAAGCTGCGCTCATGGAGCAGCCAGGCGACAGGTGATGCCGGCGTCGAGCATCGGCCGCATAAGGGATTGAACAACCGGGCGGAGAATGCACAGGTGCAGCTGCGAAAACGGGAGCGGATGATGCAAGGCTTCCGAACATCAGGAGCACTGCAACGCTTCGTTGCGATCTTCTCGGCTCTGCGCAATCTCTTCGGTCTCGGTTTGCGACATTTCGGCGGGCATGACAGCGCATAGCGCCATTCTTCAGGCGCTGTATCACCGCGAGGTCACCGGCGAAGGGACAAGCATCCAGGTGTCACTGTTCGATGCCGTCGCCGACTGGATGAACGTGCCGGTTCTGCAAAACGACTACAGCGGGTATCACACGGAACGCGCCGGCGTGAAACACCCGTCGCTTGCGCCGTATGGTGCCTATCGTTGTGCCGACGGCAAAGAGGTCATCTTTTCGGTTCAGAATGACCGCGAATGGATAAATTTCTGCGAGAAATTCCTGAAGCAGCCGGAGCTAACACGCGCACCTGGTTTTGCCGATAATATGGAGCGCCTCAGTCATCGTGCGCAACTTGATGAGATCATTGAAGCGCGTTTCTCCGAACTATCCAGCGAAGAGGCAATGCAGGAGCTTGAGGCGGCCGGCTTGGCATATGGTCGACTGAACGAAGTGGCGGATGTTTCAAGGCATCCACACATTCGCAGGGTGCAGGTTGGCACACCCGAAGGAACCGTCGAGACGATAGCCCCGGCGGCGATTTTCAACTTTGAGCGCCCCTCGCTGCGCCCAGTTCCGGCTCTCGGCGCCCATACCGAGGCAGTCCGCGAAGAGGTTCGAGCAGGCTTGCGCACAAAAGCCGCGTCAGCGTGAGCGCGCGTCTGAGTAAGGTGAGTGCGCTCGTTAGTTACGAAGAGTCTGTGTACCTCGGATCATCCCAGCGCATCGGCCATCCAGCAGGCGCACTGCCGTCACGCTCGCTAAGATTGATCGTAGAGGCGACTACATGATCAAGGACACCTTTCCGGTCGTTGAAAGCACGATGTCTGTACCACGCTGGAGATCCCTGCTCTTCGTACCCGCTCACGTATCGCGCTTCGTGGAGACGGCCCATGAGCGGGGTGCAGATGGAGTCATTCTCGACCTGGAGGACTCCGTTCCCCAAGATCAGAAGGGCGAGGCACGGAAGCAGCTTCCTGAATGCGTGGCAAAGGTGGCCCGCAACGGCGCATCTGTTTTGGTCCGCGTGAATCGTGGTTTGCGCGCCTTGGCGGCCGTCTCGATGCAGCTGTGATGGCGGGTGTTCATGCACTGGTTCTTCCAAAGACGGATTCGGCAGACTGGGTATCAGAGATCGCAAACGCGGTATCGGAACTTGAACGGGAAAGAAATCTTCCGCTGGGAAGCATCCAGTTCCTTGCCCAGATCGAGACGCCGGGCGCCTTGCACAGGCTCGCAGCCATTGCGTCGGCGGATCCAAGGATGATCGCAATGGCGCTCGGTCCTGAAGACTTCAGTGCCGCCGTTGGCGGCGCCCCGGAATTCGACCTTCTGTTGACGCCGAACCTTTCTGTTCTGTTTGCTGCCCGTGCCGCCGGTTTGCTCCCGTTAGGCTTCGTAGGAAGCATCGGCGAGCTCTCCGACACTGATAAACTTCGTGAAGCCGCGGTGCGTGCGCGGCGGCTTGGCTTTGCCGGAGCTTTGGCGATCCATCCGACACAGATGGCCATTTCGGCCACCGGATCGTCGTCGCGGCCCTCGTAGCAGACCTGCCTGCGCCCGTTATCCTCCAGCCTCACCTGCCAGAGAAAGCTTGCGCCGAGACGCACCAGGTGCCCGCCGCGCTCGACGAAGCGGTCGATGGCATCGCGCATCTCCCAGCTCCAATATTCGTCGTGGCCGACGATAACCGCGCAGCGGTAGCGATCCAGCAGATCGGGGAGCAGGTGGAGATCGTGCTGCGTCGCCATGTCCACCCGATACCCGTTCCTTTCGGTCCAGACCGAGAAATGCCGGTCATAGGTCGCCCAGCCGGCGGATGCATATTTTTTGCTGTAGCCGTTGGCGCGCGTATTGCAGGCGATCGTGAGCACGGATGTCACCGCATCATAAGCACGGATTTCATGGGATCATGAGCAACGATTTCAGACGATCGTGAGCACCTTTTTCGGAGGTGCGGGACGCTTCGGCCGACAACTCAGTCAGTCTACAGGATGCCTCGTTCAAAACGAGGAAGCCTGATGCCAACCCAGAGATTGTCGATGCGCCGGATCAGAGAAGTTTTACGTCTAGGGCATGTCCAGGCCCTGAGCGAGCGTGCCATCGCGCACACGCTCGGGGTGAGCAATGGCGTCGTGCATGGTTATCTGCGGCGCGCCCGTCTTGCCGGGCTGAGCTGGCCGCTGCCTGAAGGGATGGATGACGAAGGCCTCGAGCTGCTGCTCTTCCCGGCGCCGAAGGCGGCGCCGCAAAGCCCCAGCCGGCCGGTCCCGATTGGGCCTATGTGGAGAAGGAGTTACGCCGCCGCGGCGTAACTCGGGTGCTCCTGTGGGAGGAGTATCGCGCATCCCGGCGAGCTATAAGGGCGACTACGAGAAGAGCTTCGACGGTACCGGGCCGTTCAAGCTGGAGAAATACACGTCCAAGGTCGGCGCCCCCTTCGTTCGCAACGAAGATTACTGGGGCGACAAGGTGCTGCCGGAGCGCATCGAGTTCATATTCTTCTCCGATGATCAATCGGCTATCCTGGCGCTGCTTGGCGGTGAGGTCGATGTCATCTCACTTTCGGCGGTGGCCGGCGTTAGCCTACTCAACAACCCGAACGTCAATATCGACAGCGTGAAGACGGCCTCGCACTCGCAGTTCCACATGCGCTGCGATTCCGATCCGTTCAAGGATCCACGCGTGCGTCGCGCCGTGGCGCTCTGCCTTGATCGCGACAAGTTGGTTGCCGGCCTGTTTAAGGGCCGCGCTTCACCAGGCAACGACAGCCCGTTCGCTCCAGTCTACCCCTCGACTGACACGAGCGTGCCGCAGCGCAAGCAGGACTTCGCCCAGGCCAAGCAGTTAATGCAGGCGGCCGGCGTCGGCAAAGGATTCAAAGTGACCCTGACCACCGCGCGCTTCGTGGAGCTTCCCGACTATGCGCAGCTGATCCAGAATTGGGTTAAGGAGATCGGCATCGAGCTCCAACTCAACATGCTCCCCCTGGGCGCCTATTATGGCGATGCGGTGTTCGGCAAGTCGCCTTGGCTGGACTCGGTGATGGGCATCTGCGACTACGGCCATCGCGGCGCGCCGAACGTCCTGCTTTCCGCTCCGCTGACAAGCAACGGTAGCTGGAACGCCGCGCATTTCAAGAGCAAGGACTACGACACGCTGGTGTCCAGCTATATCGCGGCCCTAGATCTGGAGGCGCAGAAGGCAACGGCCGGCAAGATCCAGAACCTGCTTCTTGAGGAAACGCCTGTTATCTTCGGATACTTCTACGACGACCTGACGGTGACCGCGAAGGGCGTGTTCGGGATCAAGAAGACTGGCATGGGGCAGCTGTTCTTCGACAAAGCATCGAAGGCATGAGTCACAGCCAGCCCGTTGCGGGGCTGGCCCACAAGCTTATAACAGCCAGCTCCCTTGCGGGGGCTGGCTCCACGAGGAGTATTAGCTATTCTTTCCTTTCTCGTTAGGCGAGTCTCACTGTCGCTCGTCACGCTGTTCCTGCTCAGCATCATGGTGTTCCTGGGTGGCCAGGTGCTGCCCGGCAATGTCGGGCGGGCCATATTGGGTCCGCTTGCCGACCAGCGCGCCGTCGACACGCTCAATCACACGCTCGGCGTCGACCGTCCGCTGCTCACCCAATATGGCAGCTGGATCTGGAACTTCATCCAGGGCGACATGGGCACGTCCTATCTTTTCCGCTCGCCGGTGGCGCCCTTCGTCATCGATGCCTTGGGCAATTCGATGAAACTGGCGGCGGTCGCCTTCGTGCTGGTGGTGCCGATCGGCATCCTAGGCGGCGTCATCGCGGCGCTCAATCTCGACCGGCCGCTCGACCGCATCATCAGCCTTGGCGGCCTGTCGGTGACGGTGCTGCCCGAATTCGTCACCGGCATCATCCTGATCCTGATTTTCGGGGTCTGGCTGCGCTGGCTGCCGATTTCGGCCGCATGGCCGCGGGATGCCGGCTTGTTCACCCTAAGCAGTACCTGCGGTAGTGGTGCAAGCGGACCCGGACTTTGGCCCGCTGGGCTGCTGCTACGACCTTCGCTGGAAAAAAATGGGTTTTGTTGCAACGCCTGAATAGGGCGCAGAGAAGCCTGGCCATCTGGAACTGAAAGTGAGCCTCTTTGTATGATGCGCTTGGAGCGATGAGGAGCACATGATGGCAAACGCAACCGGCCGGCCTGGGGCCGCCCTGGTCCTGAGTGCGGTCAAGCGGGAGCATCTGGAGCGGCAGGTCCGGCGTCAGCGTATAGCGCGATCGATGGCGGAGCGGTGCCGGATCATTCTTCGATGCGCTGACGGTGTCCCAGAAAGGTTGTGGCAGCGGAGTTGGGCGTGAACGGACACACGGTCGGCAAATGACGACGACTTTCCTCAAAGATCGCGTCGAGGGGCTGCTGGACGAGGCCCGCCCCGGCAGACCCCGGACCATCGACGATGATCAGATCGCGGCCATGATCGAGCGGACGCTACGCTCGAGCCTGATAATGCGACCCATTGGTCAATCCGATCGATGGCACTGCGACCGGTGCTCCCATACGACGATCCGCCTATATGGATCGCCTCGGGCTGCGGCCGCATTGCTCGGAGACGTTCAAGCTGTTGAGCGATCCCTGCTCGTCGACAACGATTGCGACATCGTCGGGCTCTACCTGTCACCGCCCCAACCGGCATGCCGGAGCGCCGAACTCATAGCTATGTCCGGCACGGCACCAACTCGCTGTTTGGGGCGCTCGATGTGGCGTCCGGTTTTGTGATTGGCAAATGTTACAAGCGGCACTGGGCAACCGAGTTTCTGGACTTCCTGAAGCAGATAGACGCCAACGTGCCGCCCGATCCGGATGTCCACGTCGTCATGGATCATTATGCCACCCACAAAACCGCGCTGCTCAGGTCATGGCTGTCGCGCCGGCCTCACTACCCATCTCCACTTCACGCCCACATCGGCATCCTAGATCAATCAGGTCGACCGCTGGCTCGGTGAACTGACCTGAAAGCAGGTGTGACGCGGCGTGCATACCTCAACCAGCCAGCTCGAGGCTGATATTCGCACCTTCATCGAGCGCCACAATGAGAACTCAAAGCCCTATCGAAGGACCAAGTCCGCGGACGAAATTCTCTCGTCCGTCAGGCGTTTCTGTCAGAAGGCCGAGCAAACTCGTACTCTTCGGCATTCGTCGAGATGCTACGTGATGAAAATCTGCGTTCGAAATTTTGTAAATAATTCTTCACATACTTTTACGAAGTCTTTGCGACAGAATTTCGATGAAAAGAGTAACTTCGCCGCAAGGCTTAGAAGGCGCGGCCAGAGCTGCTGCCATCTACGCTCTGACTGCCGAACAACTTGCAAAAAAGGTCAACAGCAATGCGAAGAAGAGCGCTAATCCTGGTTGAAGGTACAAGGTCCAACGGTCCGCTTTACGTCAAAGCGGCTCGGCGTCTTGGCCTTCATCCAATTACCCTATCGGCTGATCCAACGCACTACGACTATCATGCCCCGGAAAGGCTTGAGACAATCCGGATCGATACAGACAATCTCGATGCGCTGGTCCACGAATGTGCCCGGTTGCGTGCGAGCTTTGAGGTTGTTGGCATCACCAGCGCCCTGGAGTCGGTCTATGCGACAGTCGGCAAGCTCTGCCGGCATTTCGATCTACCGGGACCGAATCCGGCATCCATTGAACGATGCTGCGACAAATTCACTCAACGTCAAATCCTCCGGGAGGCCGGCGTCCCAATACCTGCTTATCGCTTGGCGGCGAATGAAGCGGACGTACAAAGCTCCGCCGCGGAGATCGGCCTGCCGGTGATTGTCAAGCCAGCCGTAGGCAGCGGCAGCTCCGGTGTCCGACTGTGCCGCAACGCCGACGAATTAGCCGAACATACGACCTTTCTGTTGGGTGGGAAGCACATACGGCAGTCTTCACCGAGGATACTGGTCGAAGAGTTCGCACAGGGTCCGTATTATTGCGCCGACATAATGGGAAATGAGTTAATCGGGATTACCGCCTCTGAGTTCGGCTGCCCGCCGCATTTCGTTTTTCGTACCTCGACCTTTCCGGCCCCGCTGACTGATCATGAGCATAACCGCATCGCCGATGTATCGCTGAGCTGTTTGCAAGCTCTCGGCCTTGACTGGGGGCCTAAATGCATTGAATTTCGGTGGACGAAGCTTGGCCCAGTCGTCATCGAAGTCAATCCGCGTCTTGGGGCTGGGACCAGTCCTCGGCGCGTTCATCTGGCTTATGGTATCGATCTCATTACCGAGCACATCAAGTTTCTCACCGGCGAGGAATGGAATTTGCGTAGAACACATTCTCACACTGCAACCGCGCGGCTCCTCGTTCCTGAGCGTGATGGAATCCTCGAGTGGATCGCTGGCCACAGTCGGGCGGCTGCCATACCAGGCGTCGCCGAAGTGAAGTTGTACGTAGAACCCAAGATGCCGATCGTCAGGAAAGGCGATTCCCGAGACCTCTTCGGACATGTCATCGCCGCTTCACCAAGCCGTGCTGAGACCGAGGCCATACTTCAGCGCGCCGTTGACTTGATCCATTGGTCGATCAAACCCTTTGCCATCGCTGGCGAAGAACGTTCTGCGGCCATATCCAGGATGACGTGAACCGCTCTACGCCTTAGGCAACTGAGCCTCGATTGCGTTGAGGAAGCCAGCGCCTGACGGCGTCCATACGGATCGCGGCTTCATTCGATAGGGATTTCGCCGCGATCCGTGACGCCAGAGCACCGGCTCTGATAACATGACGCGGCAGGCCAAAAACCTGCATCGGGGGTTCTCCTGAAGTTTGATCTTCGCAACTTCAGCTTCGGAGACCCCCGAACTTTTCTCAAGCCATCCGTCTCACATCTGTCTGGACCTGCACACGTCTGCAGCCCAAATGTACCTATACCGCGGGCATCGGAACCCTCGAATTCATTCTGGTCCAACCAGAGCAGGACTCGCTATCGTCACGCGCCTCTTCAGGGCAAGCACTCGACTGTCATGGCCGGCGCGTCGGCCGGTAAACAATATGTAATCCGCGCTAGATCGTAACCGCTGTTTTGCCCTCACATTGTCCGCAGTTGCCTGATCTGTGATCGACGTTCCATGGACGAGCGACAAGGAGTTTCTCCATGGACACTACGTTGGAGGTTCTCACGTCACGGCGGGGCCGACGTGAGGCGCATCGCCAATGGCCGGATGAGGTCAAGGCACAGATCGTTTCGGAGAGCTTGCGTCCGGGCGTGACGGTGAACGAAGTGGCGGAGCGCCACGGGCTGAAGGCCAACCACCTGTCGTCCTGGCGCACGCTGGCGCGGCAGGGCAAGCTGGTTCTGCCCGCGCCAGAGGATGCCGTGGAATTCGCGGCAATGGTCATTGATACGCCCGCGCCGGAACCGCCAACCGCGAAGCAGACCTCCCGCGCCGAGATCGTTGTCGGTCCTGTCACAATCCGTCTTGAGGAAGGTGCGTCTGCTGCCCGGATCGCTGCCATCGCGCGTGCCTTGGCAGCGGCGACATGATCTTTCCATCGAACCGCGTGCGCATCATGGTGGCGACCAAGCCGGTAGACTTCCGCAAGGGGCATGATGGATTGGCGGCGCTGGTAAAGAACGAGCTGCACAAGGACCCGTTCACCGGAACAGTCTTCGTGTTCCGGTCACGCAAAGCGGATCGGTTGAAGCTGATCTACTGGGATGGCAGCGGCATCGTGATGGCCTACAAGAGGCTGGAGGAGCACAGCTTCACCTGGCCCGGCATCAAGGACGGCCTGATGACGTTGAGCCATGCCCAGTTCGAGGCACTGTTCGCGGGCCTGGACTGGCAGCGGGTTCGCGCCGTCGAGACCAGAGCGCCGGGGGTGATAGAATAGCTGCGGCACGATGACTCAGCACAACAAATTCCGAAGGCAAAACGGACCGGGCTTTGGTAGGTTCCGGCCATGCTGGACGCCGCTGATCTTCCCGATGATGTTGCCGCCCTGAAGGCGATGCTGATCGCGGCGAAGGCGCGCGAGACAGGCAAAGACGCCCAGATTGCCCGCAAGGATGAGCGGATAGAACTGCTTGAGAAACTGGTCTCGGCCTTCAAGCAGGCAGCCTTCGGGCGCAAGTCCGAGAAGGCCGATCCCGACCAGTTCGATCTGGCGCTGGAAGACCTGGAAACGGCCATGGCAACAATCCATGCCGAGGAGGAAGTCGATGCTCGTCCTGGGAACAGGGTCACTAGGCCGCGCGCGACCAATCGCGGCTCCCTTCCTCAGCATCTTCCTCGTGTCGAAGAGGTCCTTGAACCGGAAAGCCTGATCTGCTCCTGCGGCGGTTATTTGCATTATATCGGCGAAGATGTGGCGGAGCGGTTGGACGTAGTCCCGGCGCAGTTCCGCGTCATCGTCACCCGTCGCCCTAAATATGCGTGCCGTGCGTGCACTGACGGCGTCGTTCAGGCTCCGGCTCCACTACGACTGATCCAGGCAGGCCTACCGACAGAAGCGACCGTCGCCCATGTCCTGGTCTCCAAATATGCCGATCACCTTCCGCTTTATCGGCAGGCCCAGATCATGGGCCGCCAAGGCATTGATCTCGACCGTTCCACGCTCGCCGACTGGGTCGGCCGCGCAGCCTATGAGTTGCGTCCCGTCTTCGGTGCGCTGATTGCCGACTTGAAGCGCTCGTCCAAGCTCTTCATGGACGAGACCCGTGCCCCGGTTCTCGATCCCGGCTCGCGCAAAACCAAGACCGGATACTTCTGGGCGCTTGCGCGGGATGATCGACCATGGGGCGGCGGTGCTCCGCCAGGTGTGGCCTTCACCTACGCTCCCGGTCGCGGGGGCATTCATGCCGAACGAATACTGCAGGGATTCTCCGGCATCCTGCAGGTCGATGGCTATGCCGGATACAACAGACTGATCGCACCTGACCGTATCGGATCAGACATTCGGCTTGCCTATTGTTGGGCCCACGCCCGGCGCAAGCTGGTTGAGATCACTCGCAACGGAACAGCGCCGATTGCCGAGGACGGTGTCAAACGGATTGGTGAACTGTATCGGATCGAGGCCGAACTGCGCGGCCTTGACCCGGAGGCTCGCCTTGCTGGACGGAAGGAACGATCAGCGCCGCTGGTCTCCGACGTGCAGGCTTGGCTCGTCCATCACCGCGCCCGTGTCGCGACAAAGTCCCCACTCGGCGAGGCGGTGGCCTACATCGCTAAATACTGGGACGGTCTGAAGCTCTTCCTGACCGACGGTCGCATCGAGATCGACAACAACAGCGTGGAACGAACCATCCGGCCTATCGCCCTCAATCGGAAGAACGCGCTCTTTGCGGGCCACGACGTCGGAGCCGAGAACTGGGCGACCATCGCCTCGCTCGTCGAAACCTGCAAACTCAATGCCGTTGACCCGCAGGCCTACCTGACCGCCACGCTCACCGCCATCGTCAACGGCCACAAGCAGAGCCGGATCGATGAGCTGCTGCCTTGGAATTATCCGCTTGAGTAA

Protein sequences of DBSCAN-SWA_1

>CP034451|3841035:3930624|3889154_3890033_+|AZO10891.1|DBSCAN-SWA
MTITDTSMPTPDDTGRRGLMADVFFSLLRSATFLTGFAIVLFWISCALFGEHFVPYDPLATDIINALAPPSSEHWFGTDQIGRDVYSRVIVGSRDILTVAPLATLLATVAGTALGLFTGYFRGLVDDVVSRLLEAFMAIPGVIVALLAIVALGTSKTMVIVVIGLSFAPIIARTVRSAVLAERELDYVAAAQLRHESALHTMFVEILPNVIPPILVETTMRLGYSVFAVATLSFLGFGIQPPSPDWGLSISNNYGMISGGFWWTVLFDALAIASLVIGVNLAADGVHGALND
>CP034451|3841035:3930624|3897915_3899394_+|AZO10894.1|DBSCAN-SWA
MSLSEAVLAKLKDKSLVTDKALVGAGWVAAGSRGLTFEVTNPSTGEVLATLPDLGEEEVKSAIEAAYVAQKNWAKRTGKERAAVLRKLYDLIVSNVDDLATILTLEMGKPWTEAKGEILYGASYVEWFGEEAKRVYGDTIPGHQPDKRIIVIKQPIGVVGAITPWNFPNAMLARKMAPAIAAGCSMVSKPAAQTPLSALALAVLAERAGLPLGLFSVLTTTDAAMVGQEFCRNEKIRKVTFTGSTNVGKILMRQGAEQILKLGLELGGNAPFIVFDDADLDAAADGAMVSKYRNAGQTCVCANRLYIQEGVYDAFAAKLAERVRQMKVGDGFAEGVTTGPLIDRNALKKVQEHVTDAIAKGATVEVGGKPASQGGLFFEPTILTGATGDMRLSREETFGPIAPLFKFSTEEQVIEMANNTKFGLASYFYSRDISKIFRVAEALECGMVGVNTGLISTEVAPFGGIKQSGLGREGSKYGIDDYTEMKYVCLSV
>CP034451|3841035:3930624|3869978_3870659_-|AZO10884.1|DBSCAN-SWA
MPQKCAACGRWNFHCVYLGSNRGAGVRAAVKGLALVDVLEVGHGTLLRGIGSPKPFPAHASARTTHRRKRDRPSRGVLKLGKSEIPHEPVGPAVHKDDEALASPFVKCLLRLIRTQDSFGLWEGHSDAELLAEFIITKQQQRAVPFGGDPDPDALWRLDMFYTAVALAIEERSGVSTSPTIEMKPVGASGGWAFCRDVHRFGFETFRKLAEAGTKLVDDATAAIEA
>CP034451|3841035:3930624|3918907_3919234_+|AZO10906.1|DBSCAN-SWA
MLFVVPLAGLLVISLGMPDWTLTHYLRIGDSPVYAAVLRTTLEISLAVTTLAFVLGYPIAYALTTGGPTLRTFLLIAVVLPYFTSVLARTFAWIVLLGRGGIVNECRS
>CP034451|3841035:3930624|3860827_3861574_-|AZO10877.1|DBSCAN-SWA
MELRRIAVELDLFLKMTDDVAQSEQLFELLSAFALNFDCPWIAYGPLASERAFKPNREGSVVMWNYPAEWQERYSRMGYAKIDPLIKKGRKEAGPFRWSEVYTDENITEDGRRVLDEAATFGLRSGVTVPLHGPGGSFRFVSFAQSSDCELQNRAITYLQMAALRFHRMVTKFDTTTASERAHNLSPREIECIDLVSQGKSSWEIGTILGRSRNTIDFHLKNVMRKLDATSRTVAVVKALNLGIIEPP
>CP034451|3841035:3930624|3875635_3876493_+|AZO10887.1|DBSCAN-SWA
MLSETPMHAACRIKTRQTNEFAQFQLVWNPTLSHARRSGRGSSAAAALAHRRLTGTAADLTRVRSRGGCHAARYRDGRFAAGERLPTEPELAASFGVSRSVIREAVSRLKAVGVGSAVRGPACLSATPLLQRSFRIRGAEVGSGIALREILELRLCLEVEEPGLRQRTSERVIEEFVPAWSLAPIVRALQTLRGVDLIVAVTFATQIGDVRRFESPRQLMGYVGLDPGEWSTGETVRRGGITRAGNLRPATCHPPTAWRTSIRPCRRNWPGAHRPRPRKAIWRAT
>CP034451|3841035:3930624|3920529_3921150_+|AZO10909.1|transposase|DBSCAN-SWA
MLRSVGARNSSYPPQVIANAVWLYCRFPLLLERGIVVSYETIRRWGIKFGPDFARRLRRKQHSRNDVWHLDEVVITIAGRKHWLWRAVDRDGNVLDAIVQNRRNTKAVKRLLTRLLKKQGVAPKRMITDKLRSWSSQATGDAGVEHRPHKGLNNRAENAQVQLRKRERMMQGFRTSGALQRFVAIFSALRNLFGLGLRHFGGHDSA
>CP034451|3841035:3930624|3859141_3859984_-|AZO10876.1|DBSCAN-SWA
MILPELRSANTAGRVLEITTTTGCVVGCSYCPQDKFAVRQRKVSHASHLDLEDFKRCLARVPTSVDIGFAGYSEPWLNPDCTEMVEHAFAKGHGIRIFTTLVGMNGQDLQRLQALPLGVFVVHVFDDGTYMNSRLVGDKYRDLVRQLVDADIPLIRFVALGEPHPDIADIIPTEALIKARPVSSRGGSVDPKIVAPRQPVVGALTCVDARQYRNVLLPNGDVTLCSMDFERRHVLGNLLYEGYSALFEKPVFREIVDRMNGADGFLLCRMCEFADPNDRT
>CP034451|3841035:3930624|3916422_3917508_+|AZO10904.1|DBSCAN-SWA
MALNSNFPGGRKVAPSLTDRLETGDLLVSVESSFSATYREARGKFLAALPKARAYVLPHLTGPDGEELAVDVAWLGDPDAECVLVTISGTHGPEGYCGSGIQMDWLALIADASLPAGVAFLLVHGLNPHGIAWDRRVTQEGCDLNRNFVDFAAGTPSNPGYEELRSQFVPAALEGPVFEAAQKAIRVFKAAHGERAFQVARKAGQYVDPDGMFFGGFEPAWSARTLDAIAHDYALNTRKFVAVLNVHTGLGPYGYGELQSEHLSAIASHNIAESMFGPSVTSADLGTSSSIPIEGTLQLYWERLIGDGQYLDLALEYGTYDIEAAQRVLLATSGFTRMAAVTEPACSVARCGGAACTFLSA
>CP034451|3841035:3930624|3917657_3918803_+|AZO10905.1|DBSCAN-SWA
MSRSTNHGSPRSGLSRRTLLQTAAAAMAVPAIARATTAFAQDKLAGSGEVVVFSFGGSFTEGFRKRVLEPFSEVTGIKVVDVTADFSEPQVKAMNEAGRVDWDTAFVQGQAYPPMSQAGMFEPIDYTLWDDESLTGVPDSARLADAVAAFQSGQLLTYDERTFGEDGPKSWVDFWNVEAFPGPRGLYASAAKFSIIFALLADGVAKSDIWPLTDDKVDRALKKLDEIKPHVTKWWSAGGEPPQLLINREYVITSAFANRAIVAIRGQDAPIRMVWGAGAPFNRTYWTVLKGGPNTQNAQKLVAFANRAAIAAGFTEGVGVDTLNVNQLQHLPSDLVPLLSIHPENAHHVVLEDSAWLAATRPDGKTNIDHLQERWLAWRAG
>CP034451|3841035:3930624|3853198_3853657_+|AZO10873.1|DBSCAN-SWA
MPTPSKGVKKIPAHTEGPSGGPAERHTGGWFQDKARIGHKNGLVRQWARRGRRPRQHVPENITPIFLPSRSPELSPVENLWQYLRSNWLSNRVFATTHHRRGVRGLAETPRQSRNHHVNWKEAVGACRRLIVMTPGIVSDRPMRTSLYNPVS
>CP034451|3841035:3930624|3903800_3904943_+|AZO10896.1|DBSCAN-SWA
MGDEMGPRFSRSGLNRRTLLQSAAAAMIIPAVARATTAFAQDKLSGSGKVVVFSFGGSWTEGMRKYVYEPFTKATGIAVVDVAADFCEPQVKAMNQAGRVDWDTAYIQGMNYPAMHEAGTFFEPIDYNFWDDESLKGVPDSLRLEDAVAAIGSAMLLAYDERVFGDNGPKNWADFWNVEAFPGPRGLYAPVPKHNLEFALLADGVAKEDIWPLTDDKVDRALKKLDEIKPHVTKWWTAGGESPQLLINREFVMSNAFDGSVIAAILQGAPIRMVWEGAHVNYTYWVVLKGGPNSENAQKLIAFVNRATMAAGFTEGTVFPGPNTNQLQHLPSDLVPLLSIHPENAHHVVLEDSAWLAATRPDGKTNIDHLQERWLAWRAG
>CP034451|3841035:3930624|3913048_3913393_-|AZO10901.1|transposase|DBSCAN-SWA
MIPVPNGVKVWLATGYTDMRKGFPGLSLMVQETLKRDPHTGHLFCFRGRQGGLIKVIWHDGQGACLFTKKLERGRFIWPSADGTVVITPAQLGYLLEGIDWRMPQKTWRPSSAG
>CP034451|3841035:3930624|3851515_3852544_+|AZO10870.1|transposase|DBSCAN-SWA
MQVITIGLDIAKNVFQVHGVDNAGNAVLRRKVRRDQLIPLLRDMQPCLIGMEACATAHHWARELIALGHVVKLMPPAYVKAYVKRNKNDAADAEAICEAVTRPTMRFVAVKSADAQSILMLHRARHLLVRQRTAQISAMRAHLAEYGVVAPKGRAHVRGLIEALDKGDGPLPAMARQVLILLARTIEGLGAQIRKIEIELLAWYRTNQVCRRLSTIPGIGFITATALAATVVDAKVFRSGRQFAAWLGLVPKQHSSGGKDRMGGISKMGDRYLRHLLVVGATAVIRYTRRKATTVSTWANQLLERKPARLVTVAVANKVARIAWAVMAREENYRATPSMARG
>CP034451|3841035:3930624|3843530_3845009_-|AZO10866.1|DBSCAN-SWA
MSLSEAVLAKLKDKSLVTDKALVGAGWVAAGSRGLTFEVTNPSTGEVLATLPDLGEEEVKSAIEAAYVAQKNWAKRTGKERAAVLRKLYDLIVSNVDDLATILTLEMGKPWTEAKGEILYGASYVEWFGEEAKRVYGDTIPGHQPDKRIIVIKQPIGVVGAITPWNFPNAMLARKMAPAIAAGCSMVSKPAAQTPLSALALAVLAERAGLPLGLFSVLTTTDAAMVGQEFCRNEKIRKVTFTGSTNVGKILMRQGAEQILKLGLELGGNAPFIVFDDADLDAAADGAMVSKYRNAGQTCVCANRLYIQEGVYDAFAAKLAERVRQMKVGDGFAEGVTTGPLIDRNALKKVQEHVTDAIAKGATVEVGGKPASQGGLFFEPTILTGATGDMRLSREETFGPIAPLFKFSTEEQVIEMANNTKFGLASYFYSRDISKIFRVAEALECGMVGVNTGLISTEVAPFGGIKQSGLGREGSKYGIDDYTEMKYVCLSV
>CP034451|3841035:3930624|3848815_3849844_-|AZO10869.1|DBSCAN-SWA
MARHRPGTTAVATRNKYEILGADIPEETLFKGDLLVASLSESPRSVNSIYYYDDAGSRLFERLCHEETYYLFRTEKDILAEHARSIADITGPIFIVELGSGNAEKTTLLFDAYLKEHGRTFYAAIDINRSILERAAENVLSVTDDLDFLGIVGTYQTGLAQVANLIGPKLLVCLGSTMGNMHDDELHDLLLSARSALSSGDYLLVGMDLDKETKILEAAYNNQTAILTNLCVLQHLNWRFGGDFDPFQFRHVAFHNKSLYRMESYLEAMQEQMINLKSLNFSFHLEKGEMIRTEIMRKVELCAFHKLLGLYNFRPVQHWTDSRQQYAVSLFQLGAEPTELES
>CP034451|3841035:3930624|3846804_3848163_-|AZO10868.1|DBSCAN-SWA
MITFSEFAASLTYDAIPEEVRAILRRSFADTLGVAVVGATTQISSITREIADRLWRSSPEIGAARMIFDGRPVSPAGAAFAGAFTIDSIDGHDNNSPCKGHAGSAVFPALLAVADSLRSSGAAISGREFMVALAVAYEVAYRAGLTLHGTVSDYHTSGAWTAVGVAAGVSRLLGLSQEQTRHAAGIAEYHGPRSQMMRCIDFPTMLRDGVGWGAPSGVMAAYLADLGFTGAPAITAEGASAEPWWCDLGEAWRVAEDTSYKPYPVCRWAHPSIDAARDLMHDNCLSSNDVTRVRIQTFHNAVRLAGHNPKTLDEMSYSIAFPVATMIVRGKIGPQELLPEVLQDEEIRRISNATELVETEHYTRISVGKRWADVTLYLKDGRQIMSEPRTPKGDRDNPMSAEEFHSKYVNFTNGLISDGRAEEMEAIALSFDRLDNKGLNRLIGLTVAPLDH
>CP034451|3841035:3930624|3926492_3927749_+|AZO10911.1|DBSCAN-SWA
MRRRALILVEGTRSNGPLYVKAARRLGLHPITLSADPTHYDYHAPERLETIRIDTDNLDALVHECARLRASFEVVGITSALESVYATVGKLCRHFDLPGPNPASIERCCDKFTQRQILREAGVPIPAYRLAANEADVQSSAAEIGLPVIVKPAVGSGSSGVRLCRNADELAEHTTFLLGGKHIRQSSPRILVEEFAQGPYYCADIMGNELIGITASEFGCPPHFVFRTSTFPAPLTDHEHNRIADVSLSCLQALGLDWGPKCIEFRWTKLGPVVIEVNPRLGAGTSPRRVHLAYGIDLITEHIKFLTGEEWNLRRTHSHTATARLLVPERDGILEWIAGHSRAAAIPGVAEVKLYVEPKMPIVRKGDSRDLFGHVIAASPSRAETEAILQRAVDLIHWSIKPFAIAGEERSAAISRMT
>CP034451|3841035:3930624|3914777_3916214_-|AZO13086.1|DBSCAN-SWA
MKVTSATSGNDSLVARLREVLSPGALLYNSSDRAAFETDWRRLRSNSALCVLQPSSTAEVASCLRLCAEAGVAVVPQGGNTGLVAGGVPVAGVPQVILSLRRMKAIRAMDTVGDSVTVEAGATLASVQEAAAEAGRLFPLSLAAEGSAQIGGAVATNAGGLQVLAYGSMRALVLGLEVVLPDGRVWDGLRTLRKDNTGFDLKQLFIGSEGTLGIITAASLKLLPKVSQRVTALVGVSCVGRALDLFQIARSRVGSALTLCEFIAGEAMQLVSRHVPDARPPFEASAYLLLEMSSPNAEDSLAAVMESLLEKALSIGVAQDAVIAQSGRERSQLLRLREEVSEAELAAGGAVKHDIAVPIDLIPETVAAIEDMVRTRFPDCRPNIFGHLGDGNLHVNIRPPEGCSVADIGPLYDAITLAVEDVAMERRGSFSAEHGIGQMRIASLRRHKGEVDIALMSALKRTIDPHNILNPGKVLPES
>CP034451|3841035:3930624|3867896_3868910_-|AZO10882.1|DBSCAN-SWA
MLEKFERYPLTFGPTPIERLDRLGKHLGDKVEIYVKREDCNSGLAFGGNKLRKLEYIVPDAIASDADTLVTIGGVQSNHTRMVAAVAAKIGMKCLLVQESWVPHDDAVYDRVGNILLSRIMGAEVRLVDEGFDIGIRRSWEKALYEVKARGGRPYAIPAGASVHKYGGLGYVGFAEEVRAQEEQLGFAFDYIVVCTVTGSTHGGMLVGFAKDGRQRNVIGIDASAMPAKTKAQVLGIAQNTAKLVHLGAEIVEADVVLFMDYAYPGYGVPSEETKEAIRLCARLEGMITDPVYEGKSMQGMIDLVQRGFFPQGSRVLYAHLGGAPAINGYGYTFRNG
>CP034451|3841035:3930624|3865378_3865816_-|AZO10881.1|DBSCAN-SWA
MTNNEIPPVGPAVNNDDEALASPFVKCLLRLIRTQDSFGLWEGHSDAELLAEFIITKQQQRAVPFGGDPDPDALWRLDMFYTAVALAIEERSGVSTSPIIGMKPLRASSGWAFCRDVHRFGFETFRKLAEAGTKLVDDATAAIEA
>CP034451|3841035:3930624|3842598_3842820_+|AZO10864.1|DBSCAN-SWA
MHLAILCALFFCPANGSTPWVSHRSSMVSVSAAWADKAFDSNTIIALNERGAKIIISQHSRRTFPLPLDKALY
>CP034451|3841035:3930624|3919221_3919476_+|AZO10907.1|DBSCAN-SWA
MPLMILPMATVMSGIDQKLLRAVRANGASPLAAFLTVFLPLSLPGVIAGVLLVFIYCLGFYTLLLTLHVAAGQSGLGSPQAMRV
>CP034451|3841035:3930624|3872507_3873707_-|AZO10885.1|transposase|DBSCAN-SWA
MTDDMMDLRTLVEKTPDADILREMIGFAAERLMELEVGAATGAAHGEKNPLRLVQRNGYRDRDWETRAGTVELRIPKLRKGSYFPSFLEPRRMAEKALTAVIQEAYVQGISTRSVDDLVKAMGASGVSKSQVSRLCEEIDGKVKAFLERPIEGDWPYLWIDATYLKVRRGGRIVSVAVIIAVGVNADGRREVLGMEVGTSEAEPIWTEFLRKLTRRGLRGVKLVVSDAHEGLKAAVTKVLSATWQRCRVHFMRNVLAHAGKSGRRVVSAFIATAFAQETPEAASAQWRAVADQIRPKVPKLATIMDEAEPDVLAYMTFPKEHRTKLHSTNPIERLNGEIKRRTEVVGIFPNDDAIVRLVGALLLEQNDEWAVQRARYMTLETISQMSDDPLISLPAVAR
>CP034451|3841035:3930624|3845302_3846547_-|AZO10867.1|DBSCAN-SWA
MPRMRSSPIENCSSLSQKLNIFLCSDATDNSHLDRVPGRRCYGRAARVWHLSALLEPTLQKEAPHEPLKKIDADAPSLLKLRDEAGQAGHTIKRIAVAYEAAGDGFWLARWLRARDIEVYAIHPASVRCRVSTGVPRYFGYTIRRVPVDENFRAIVSAMSEAVSENTVMMLASMPSWSHGVCDPVRELAEIASQHGIWLHVDACVGGFLAPFVRELGRDVPDFDFRLSGVSSISADFHKYGYSGKGVSGVFYKNKVARHQPFIFDTWAAGLYRSPVLTGTRSGGAIASAWAVMRYLGRDGYLSRAAQILKLRDAILAFVAQCPGLKIVGGAELNVVGIRSEYSDIYSIASRMKEYGWKINILKEPEAIQFVLGPLRDEYITLLVNDLEKVVEVVRREGFRVPTPAVVYSDEFLD
>CP034451|3841035:3930624|3866139_3867297_-|AZO13081.1|DBSCAN-SWA
MELRMGSPAPAIKVENWLRGEPLTNFRPGKVYLVEFWATWCGPCVDAMPDLIELQEKYEGSGFEAVGVAACEQGPTADEARTNVDAWLTEKFPNLNYRIGFDYIGEMNKLWLDPSSSIGIPTSFVVDRDGHIAFIGHPAELDDVLPKVLNGSWRSSYEAKAADAKRIAHNQLAAREMSLTGPIYAKLEPAMQAEDWTAALLAIEEGLALMPDSCEFRQIHADLLLHKLRDIKTGMPVMRELVEDAIDKTSDAVSWMALALNQLFDPTMDNSHLPRAERFAMGNELSEQILALNPPNGDGPFKYLRYLPVAQYYYESGNKDRAIELIEVALKSVDRLGPIPDHTKQYYLTPLLEALANYTGEPACHADLCVAPQKKAPETQNAVTS
>CP034451|3841035:3930624|3873985_3875284_-|AZO10886.1|DBSCAN-SWA
MDLFCIGVGAGPSNLSLACQIQEEIAQGALFLDREVDFRGHPGSAFDCAELQVGHFQDLVTLVNPRSAYTFVNYLHENGRLYNFLNAQFHGVLRAEFAQYLNWAFQKNPLVRGGEAVREIRFDGEFRVRTDNAVLDARNLVIDIGKQAQIPPQFHGWTGPNLFHSSELAHINPEVQKKHVCVVGGGQSGAELLLHLVGRPKERRPAAITWVLTREMPFDDHAFTNGLFTPCFSDRFAAMSEVHRQLFLRRFALASEGISESKLRAVYQALYHHAFLEPHQCEITLRPSCNVSRCINAGAGHRLTLQRGLDNIGEVTADIVILATGYEKPLPGFLEPIADRLEQIGNELAIGEDFSVYWDGPRDRRLFVQNACLGQRGLADPNFGLLAWRARRILDSLLRRAPCANPEHLGFINRPLTECWPDLGVEQMGSGI
>CP034451|3841035:3930624|3902352_3903450_+|AZO10895.1|DBSCAN-SWA
MNLDSAKELASVVFSDNYFEARQKFLAAAPTSRAYRCRTNGPSGEALYTDAAYFGPADAKKLLVLVSGTHGPEGYIGSAAQLLFLRAKFHERLPSSTAVLFVHALNCYGFAWDRRVTAEGVDLNRNFVDFSKPLPSNPGYEELAEHFVPADISEEGLKRAEAAFAAYQARHGELKLREARGSGQYTNPGGLFYGGTEPTEARRTLEEITKEFNVAARDEVIIIDYHTGLGPYGYGELQCEQSSGLGGYERAINIFGPSVTSPEVGNSSAEIIPGTQDAFWERILGSRHTYIALEFGTYKLNTAVLRDDHWLFMYQPEEADSERGRQIRQVAKLHYYPQGSDWKEMIAWRSHQVHRQAIEALASGE
>CP034451|3841035:3930624|3907904_3908993_+|AZO10899.1|DBSCAN-SWA
MLKAIHDTAVVKTGGITLRSLGKRYGSAVAVDDVSLEVLPGEFVSLLGPSGSGKTTTLMMIAGFTVPDSGQILLDGKDITRLPSHRRELGVIFQNYALFPHMTVAENVAYPLRMRRMGKTAVENSVKRVLEQVQLGALAARYPHQLSGGQQQRVAIGRALVFDPPVLLLDEPLGALDKKLRQHLRTEIKALHKDVGKTMIYVTHDQEEALAMSDRVAVMHEGRIRQASSPRDIYRRPAELFVASFVGEANLVPVKLKGGVAYSSDGRRLEATRWDGDDMEAMLCIRPEHVRLDLGDVGMASGPQGTVVDSTYVGDATVIECETDSGLRLTSKVLNQSGDQIPTIGSSCRVRWAATDATILTN
>CP034451|3841035:3930624|3862211_3864014_+|AZO10878.1|DBSCAN-SWA
MRRFPVHGRGATCRDVFAFTVRLWNRQPARLAIIMTAMLASTLADVLMPLYSGRLIDAVSRAANAAAPASDSAVAAFSVPIALALGGIAMRHVAFIGLSDLVLKMISDVATEAFHHVQRFSTDWHANSFAGSTVRKITRGMWALDLLNSTILVTLLPSFVILIGSTVLLGWHWPVMGAIFACGSLVYLAFSISLSLGYVAPAASLANRWDTRLSGALADAVSCNAVVKGFGAEVREDERLANIMTKWRHRARRSWVRGTIIGSTQGVTLVALRVAVVGYALLLWSHGQATPGEIAYVLTSFIVLQGYLRDAGMHVRNVQHSVNEMEELVAIHNQHVDVADRPEAKPIRITKARIDFENVHFRYANHPLPLYSECSLSIEAGERVGLVGPSGSGKTTFVKLIQRLYDLSGGRILIDGQDVSEVTQESLRSQIAIVQQEPILFHRSLAENIAYGRPGASQAEIEQAARLASAHEFIAPLPKGYGTLVGERGLKLSGGERQRVAIARAFLANAPILILDEATSSLDSESEVLIQQAVDRLMVGRTTLVIAHRLSTVRSLDRLLVFDRGRIMEDGDHAALINLDGGIYRRLFERQALELAKGLA
>CP034451|3841035:3930624|3878649_3879180_-|AZO10888.1|DBSCAN-SWA
MLRFFEKQPACLVGLDLRWSTYWRARSQHFGHEVRLISPCYVKTFVKRARAMRADKTDGTDGLVCDQLLQLRVLVIQSLQALGVGDVHPAILGACQSYSVDERIEKASNGSHSSRQRRKLPLRIDRSRSSEGLQGIKSLRQGGHFMFLDDTEPLAASRRWRRMALGVPAAKTSLST
>CP034451|3841035:3930624|3865128_3865332_-|AZO10880.1|DBSCAN-SWA
MSDLDKMRKKVRKLQLRAAIAKMALQDLVEGLPGKWADIQEVAEKTQAVYAELDVAKRELASMKNLG
>CP034451|3841035:3930624|3841846_3842281_+|AZO10863.1|DBSCAN-SWA
MLQENGRLPIKVLADRVGISVSPCWQRVKKLEKDGIIRRYIAEIAIEKLQSIQGVLSKVVLSRQNRDALEFFERHVCAIPEVAECYEVVGHFDYHIKFVVSSIDRYTEIVERFLTPGFGVERYFTDIVSRVAKEDRAIQLRRFG
>CP034451|3841035:3930624|3929067_3930624_+|AZO10912.1|transposase|DBSCAN-SWA
MLDAADLPDDVAALKAMLIAAKARETGKDAQIARKDERIELLEKLVSAFKQAAFGRKSEKADPDQFDLALEDLETAMATIHAEEEVDARPGNRVTRPRATNRGSLPQHLPRVEEVLEPESLICSCGGYLHYIGEDVAERLDVVPAQFRVIVTRRPKYACRACTDGVVQAPAPLRLIQAGLPTEATVAHVLVSKYADHLPLYRQAQIMGRQGIDLDRSTLADWVGRAAYELRPVFGALIADLKRSSKLFMDETRAPVLDPGSRKTKTGYFWALARDDRPWGGGAPPGVAFTYAPGRGGIHAERILQGFSGILQVDGYAGYNRLIAPDRIGSDIRLAYCWAHARRKLVEITRNGTAPIAEDGVKRIGELYRIEAELRGLDPEARLAGRKERSAPLVSDVQAWLVHHRARVATKSPLGEAVAYIAKYWDGLKLFLTDGRIEIDNNSVERTIRPIALNRKNALFAGHDVGAENWATIASLVETCKLNAVDPQAYLTATLTAIVNGHKQSRIDELLPWNYPLE
>CP034451|3841035:3930624|3880046_3881225_+|AZO10889.1|DBSCAN-SWA
MRNLNFSEAEYKSRLRRVKERMLTEGVDVLVVTEPANIYYLSGYDAWSFYTVQALIVFQEVETPLWVGRLIDSATAHVTTYLPADRIVPYPDVYVQAADRHAAQFIADMILCDCPSAKVVGVEMGAYYYTARDHAELVKAMPNVRFKDVELLVNWVRFIKSEQEVAYMRQAGEITERMMARAVEVAAPGIRECDVAAAIYHAQMSGTESCGGLPATSPPHMGFGARAREAHPIFSDRPIDPNSVANIEISGCRLRYHAPMSRTIYFGEPPQNYRDLASHVIEGINASLDVMRPGATCEMIEAAWRKTMSAHGIEKESRLGYSIGAAYTPTWGERTASIRRGDRTVLQPGVALHLMAGLWLEDTGITITQSLVVTGRGYEALTTTPRELIVKN
>CP034451|3841035:3930624|3888204_3889158_+|AZO13083.1|DBSCAN-SWA
MLSFLVRRVSLSLVTLFLLSIMVFLGGQVLPGNVGRAILGPLADQRAVDTLNHTLGVDRPLLTQYGSWIWNFIQGDMGTSYLFRSPVAPFVIDALGNSMKLAAVAFVLVVPIGILGGVIAALNLDRPLDRIISLGGLSVTVLPEFVTGIILILIFGVWLRWLPISAAWPRDAGLFTQLYYLILPSLPLFLVLFGYIARMARSGMIEALDADYTRTAVLKGLPWRTVIWRHVLRNALLPTITVIATQTGYLIGGLVVIETLFRYQGIGSLIFTAARGKDFPILEAGTLTIGIVYAIATLAADFLYCVLNPRIRLETDQ
>CP034451|3841035:3930624|3899615_3901049_-|AZO13084.1|DBSCAN-SWA
MRVSEYAEYDATGLASLVHSGEVTPLELTRLAREAHDKVNPHINAVVEFYEDAETVAGANGGIFHGVPFLRKDAGETEAGRLQEQGSRLFQGCRAEIDSYFFQSARKSGLRTIGRTATPELGMSIMGESMINGITHNPWNLERSTGGSSAGAAAAVAVGITPIAHGNDGGGSIRIPAAWCGLVGLSPSRGRVSGGPCNQDASFGLSREFVLCRTVRDMAGALDAFSDPYPGDPFIIVRPNRSYVEELSQPTGTLRVGVARTKWGEVDCEPEVLNAVESTAALLEEMGHNVTDIEPPYEPIEYLRSNLAKTFFFATSLEETARTLGRPINADTLEPINLKLYEYGRNSQRRPGDAEEGYRRMRRRVGEAIHAFDILLTPTMPMVALPHGGLNSTINPTLSAEEFKAADAAHIQYTGVFNVSGQPAVSLPLAQSASGLPIGIQIVGRFGDEGTLVRIARDLEEARPWNKRRPKTWAGGK
>CP034451|3841035:3930624|3864814_3865129_-|AZO13080.1|DBSCAN-SWA
MRTFTTRDGSIWMPSYLTSIDSKTCIGCCRCFKVCSRDVMHLHGVDDAGEILGPCDDEDDDFDGKLNRMIMVVDDAGRCIGCGACGRVCPKNCQTHVAADELAT
>CP034451|3841035:3930624|3890025_3892080_+|AZO10892.1|DBSCAN-SWA
MTSSAKAKNALELNDLSVAYRVAGRNRAVLRNLSLTIGQGEAYGLVGESGCGKSTVALTVVRYLPRNGSITGGAISLDGQDVMNLDAEALRRARAESVSMVYQDPGKALNPSIRVGRQLTEIFELGGITGQAAIDKAIAMLNRVRISDPGGVMQRYPHQLSGGMQQRVAIAMALANDPTMLILDEPTTGLDATVEAEVLDLIAQLRQELSASILFISHNLAVVSNMCDRVGVLYAGMLVEEGPTEVVFSDPRHPYTVALLRCLPRGGQRKHQGRLDTIPGFLPGIGVDIKGCAFADRCALATDRCRSELPPLYNLSDDRGVRLSRCHYHEQAQSLPRATQRDVAPLAPKATAVPVLRVAGLNKTYGNALRAVKDVSLTLRSGETLGLVGESGSGKTTFARLLLGLVSPDEGGTIELEGKPLAPRLENRSDDQIKAMQIVFQNPDSALNRSHSVRYLIGRALKRLAGLSGKALEARLNDLVRSVRLTDRHLTVKPRQLSGGLKQRVAIARAFAGDPRIVVCDEPTSALDVSVQAAILNLLADLQSKEDVSYIFISHDLGVVRYLSDKIAVLYLGRIMEIGPSEKVFSGPHHPYTEALLSAVPKLDHTEMSRIRLDGEIPSATHPPSGCVFHTRCPRKIGAICEEQEPPLAEAQPGHSIRCHIPYAELAKLQSSKTTKGGFVAMAE
>CP034451|3841035:3930624|3913975_3914764_-|AZO10903.1|DBSCAN-SWA
MAINDRMRTTAESNGPEGEPDRRIGRPLPLADRVVAALQEDIETGRFVAGGRLPTEPELAASFGVSRTVIREAVSRLKADGILVSRQGAGVFVSDAPLQRSFRIRDAEVGSGVALREIFELRLCLEVEGAGLASIRRSQADLVALRHWLEEMDRTKLGQDVGVAADIEFHRAVAAASGNGKVADFQRYLSLLLNQSVTIARINTLKQRGPAHVDGVIGEHRDIFHAIDAGSAADARSAMRRHLLQAAMRLGVMEGKEVVMLS
>CP034451|3841035:3930624|3913484_3913826_-|AZO10902.1|DBSCAN-SWA
MKAASPSGSTRSSPVTKHQIEVITSVERRRRWSREEKERLVAATFEPGASVSETARSAGIHVSQLFRWRKELCQISAPSVPQLVAVEVVEALPARNRQRSHRRSPDRARRAAW
>CP034451|3841035:3930624|3853089_3853245_+|AZO10872.1|DBSCAN-SWA
MAPRRSPAGHQGALRRRVLKRLGFSHMSARPRHPAQDADTVEGCKKNSRAH
>CP034451|3841035:3930624|3892880_3893774_+|AZO10893.1|DBSCAN-SWA
MEPWGWCEETWRQRVGKVRAGRSLKPASWKGGARCAVALSFDCDHETSELVLGGNSIGRLSAGEYGSRVGVPRILNTLKRNGISATFFIPAVSALLHEDEARRIVGDGHEIGIHGWIHEFNSILAHEVERELQCRAADTLERVSGQRPLGMRTPSWDFSQHTLQIAQELGLIYDSSLMADDDPYELLGDGVPTGIIELPVEWIRDDGVYFNMDLQSALRPQMSPMAVLDVFRREFDQAWGEGGLFLLTMHPHVIGHRSRMFILEELIAHITSRSDVWVATHGDVARYLKEMTATPTL
>CP034451|3841035:3930624|3842829_3842952_+|AZO10865.1|DBSCAN-SWA
MIENFFAKLKEFKRIAMRAYKTDQSFAAFINLAAAVINSR
>CP034451|3841035:3930624|3909159_3909513_+|AZO13085.1|DBSCAN-SWA
MEKITRYEVGPRMSQMTVFGDMVYTAGIVALRAPGRPVADQTADILAKIEDLLAVAGTEKGKLLTATIWLSDMSTFAEMNRVWDNWVVPGRTPCRACVEAALAGSGYTVEIQVTAAL
>CP034451|3841035:3930624|3919579_3920536_+|AZO10908.1|DBSCAN-SWA
MEIQGPTVVISGESAKAYAELVKDRFPDLRVIQAPDASSLEKHIAEAEVLLGFRFPVEVFDKASKLRWFQSTGAGVDSLFPIRDRIGHITVTNARGIHGEVIADYVMAAVTMLHWDFRGFLHDQANKRWRPRPVSPLSDKTIGVVGLGSIGATIARRAKSAGMIVLGSKRDVTVPVDGVDELFAPDGMVDMLPRCDFVVLALPATPDTVGFFGPAEIACMRPDAYLINIARGSVIVEAELIKALQRGAIAGAMLDVFEQEPLPPTSPLWTMPNVIVTPHTAGYPANYETRSFSVFADNLKRYMGGQELMNIVDMKRGY
>CP034451|3841035:3930624|3909499_3911566_+|AZO10900.1|DBSCAN-SWA
MRRFRLNASVLKRKAVVYVRQSTQAQVQLNLESQRRQYELVDVARRWGFRKVEVIDEDLGRTASGAVERPGFERLVDDLCTGHVGAVLCREASRLSRNGPDWHRLLELCGEVDARVIDLDGVYDPRLPNDRLLLGMKGSISGFELGVLRARMYEAARAKAQRGELRISVPFGYVWHRDYGLGFDPDKRLQETIRLIFARFRELGSARQVLISMIDDGVHFPRPSDGKKMVSFDWVPIRYRNVISILKNPFYAGAYVYGRSEKRTEIVDGRVRKSYGHYKPASESAVVLKDHHEGYIGWSEYERNQELLAANAYGKAGGVKSGRGGRALLPGLISCGRCGRRLVVMYAGRGQGYPVYRCERGNLMMAQARCMSFNGFRTDAAVTREALEAVAPMAIEAALEAERMQLESEAKRRQMIEMDLQQARYEASLAERRYAACDPENRLIAAQLERSWEATLRRVETCEARLSEVQRVEPVDAVPDFTGLAQNLEAIWNAPGVDMRCRQQLLRALIKDIVADVDDDARDVILTIHWHGGQHSQVRVRKPKSGEHGQRTPEEALAIMRSMATRWSDAEIAATLNRMGMQTGQGKTWTARRVQSLRTVHKISGYRSSDKNGEWLTMSDAAAKLGVSHVKIRRFIRDGLLPAEQVMRGAPYQIRASDLEDERIKADLARNTPRRIHDDNQESLFSAI
>CP034451|3841035:3930624|3841035_3841200_+|AZO10862.1|transposase|DBSCAN-SWA
MSMPGVGPIVPLTYAAAIDDLGRFRSSKRVGAHFGLTAKRYQSGETDYTAASAR
>CP034451|3841035:3930624|3869146_3869446_-|AZO10883.1|DBSCAN-SWA
MLRPTSSQHDLAKTRGAACTSSFCRLVGLVLCSNASMVYFALDSLRVAVVTTLACSLLLQAGYFGRVLFLIWQSSSRARGTRHRGQHADGYRKARVPVV
>CP034451|3841035:3930624|3886455_3888117_+|AZO10890.1|DBSCAN-SWA
MSKNYRTLDQIRRNHSPLENHLVDGLVDGRVSRRDFIRHGSLLGLSLPLLSGIATVAGFSGMPSLARAQGSPGATIRVAGDMPAATIDPVTISDGGSFVLLGQVGEYLCIAGSDLVLQPALAESWKPNDTGTMWTFKLRKGVKFHSGGEMKADDVVASIDRLADPANSSNALSVFRGLLQKGATKKVDDYTVEFHLDAPNGNFPYMVSSDNYNAIIIPASYKGDYEKSFDGTGPFKLEKYTSKVGASFVRNENYWGDKVLPERIEFIFFSDDQSAILALLGGEVDVISLSAAAGVSLLNNPNVNIDSVKTASHSQFHMRCDSDPFKDPRVRRAVALCLDRDKLVAGLFKGRASPGNDSPFAPVYPSTDTSVPQRKQDFAQAKQLMQAAGVGKGFKVTLTTARFVELPDYAQLIQNWVKEIGIELQLNMLPLGAYYGDAVFGKSPWLDSVMGICDYGHRGAPNVLLSAPLTSNGSWNAAHFKSKDYDTLVSSYIAALDLEAQKATAGKIQNLLLEETPVIFGYFYDDLTVTAKGVFGIKKTGMGQLFFDKASKA
>CP034451|3841035:3930624|3856826_3858083_-|AZO10875.1|DBSCAN-SWA
MDTDAFTAHESNVRRYCRAFPTVFTKALGATIWDETGKPFIDFLVGSGALNYGHNNPDIMAPAIEYLVGENILLSLDMHTAAKRDFIEGFVDWILKPRGLSYKIQFPGPTGTNANEAALALARKYTGRSSVMAFTNAFHGMSLGSLAVSGSASTRELGGVARHDVIRVPYDGYPSQAFDSASYIDHVLSDPGSGIEKPAAIILETIQAEGGMNAASAAWLTEIQRICRTHGIVFIVDDIQAGAGRTGDFFSFESAKMEPDIVCLSKSLSGSGSPLSIVLIRPDLDIWKPGEHSGTFRGNNFAFVTAGAMCKMWSDRKFTAGVERTAVRLQTHLDRLVAKFPRYIEQKRGRGLMAGLKCRSPAVVGRVHDVAFENGLLIESSGPNRDVIKVLPPITITNAELDRGITILEHTLQEQDNA
>CP034451|3841035:3930624|3904927_3906691_+|AZO10897.1|DBSCAN-SWA
MAGGLISPSVNGAPEPVRAPALGGPTGWAWLLLPGGVYLTVLFVVPLAGLLVISLGMPDWTLTHYLRIGDSPVYAAVLRTTLEISLAVTTLAFVLGYPIAYALTTGGPTLRTFLLIAVVLPYFTSVLARTFAWIVLLGRGGIVNEILLQLGLISQPITMLYNRFGVIIGMTHIIMPLMILPMATVMSGIDQKLLRAARANGASPLAAFLTVFLPLSLPGVIAGVLLVFIYCLGFYITPALLGGLADLTITMAISTQVVDQLNWNFGSALSVVLLVTVLVILWIGSRLFPIQQLLGFSDGIGRDAAARQMGARWLMHVGSAANALDRWLPSFGGRGIPILAVILATLLLLPVLIVAYLSFSSSPYFVFPVPGYSLRNYQAYASSASWIEATFTSIRVALLAAGMATVLGAMLALGLSRGRIRGRGAMVALVLSPIIMPTIVVAVATYFLLVQVGLQGTEFGLALGHAVHAIPFVVVIVVANLRDLNPACERAARSLGAGPLATFRTILAPLIMPALIVAAFFAFLTSFDDVIYVLFLGIGTVNTLPMRMWEGIKQDVNPIISAVATLQTALAAIVIIVGALLGRRKNT
>CP034451|3841035:3930624|3852918_3853065_+|AZO10871.1|DBSCAN-SWA
MDRQTLRDWAHRFNEAGPDGLLDSWSDGPHHGFCPSNRQSWPRLSKRA
>CP034451|3841035:3930624|3923323_3924484_+|AZO10910.1|DBSCAN-SWA
MTKASSCCSSRRRRRRRKAPAGRSRLGLCGEGVTPPRRNSGAPVGGVSRIPASYKGDYEKSFDGTGPFKLEKYTSKVGAPFVRNEDYWGDKVLPERIEFIFFSDDQSAILALLGGEVDVISLSAVAGVSLLNNPNVNIDSVKTASHSQFHMRCDSDPFKDPRVRRAVALCLDRDKLVAGLFKGRASPGNDSPFAPVYPSTDTSVPQRKQDFAQAKQLMQAAGVGKGFKVTLTTARFVELPDYAQLIQNWVKEIGIELQLNMLPLGAYYGDAVFGKSPWLDSVMGICDYGHRGAPNVLLSAPLTSNGSWNAAHFKSKDYDTLVSSYIAALDLEAQKATAGKIQNLLLEETPVIFGYFYDDLTVTAKGVFGIKKTGMGQLFFDKASKA
>CP034451|3841035:3930624|3906729_3907911_+|AZO10898.1|DBSCAN-SWA
MLTASQLLPLDAIDQLPFTPGEFDARLAACRRAMTERGLDYLVLSSPENIYYLSGFITKGYYVFQALVLTHTSDPILVVRRYEQANVERLSYYRNAAIWQDTDVPAEVLARALVDLGALGKTVGVDANSMFLTVNAYETLRAALPGTNFVNASTILERCRAIKSPQEIAYIRRAAETLSAGFKAAHEAARPGRTENDVAAAFHHAAISAGSEYMGSAPYIASGPRTALPHATWAGRCIEKGDLVIVEGSGNWKRYSAALMRTWCLGKPSDSVRRAADTSKAALAAAIAAMRPGVTSGEVDAACRGTVARAGLAHAFLNRTGYSVGVGICPGWGEGWVMDLKDGDPRVLHPGMVFHIVPVLFPEPNISVGFSATVLVTETGAEIVSDYSRELEC
>CP034451|3841035:3930624|3870742_3871888_-|AZO13082.1|DBSCAN-SWA
MELRMGSPAPALKVENWLRGEPLTSLRPGKVYLVEFWATWCRPCVHAMPHLIELQEKYKDSGFEIIGVAACEKAATADEARTNVDAWLTEKFPNLNYRTAFDCTGEMKKLWLEPSSSFGIPTSFVVDRDGHIAYIGHPAPLDDVLPKVLNGSWRSSYEAKAVDAKRISRVRESSLSQPIYAKLGPAMQDEDWAAALLAIEEGLAVMPDSFDFRRVHADILLHKLRDIKTGLPLMRELVEDAINKKFEAMSWVVMALNQLFHPTIDNSHLPHDDRFAMGKELSEQILELNPPQGDGDFKFGCYFPVAQYYYESGNKDRAIELIEVAIKSLDHSEPVPDQTKQRYLTSLLQALANYTGEPACHAGLCVAPQNKTSETQNAVTS
>CP034451|3841035:3930624|3864611_3864818_-|AZO10879.1|DBSCAN-SWA
MIWRKPGERRCTSSFCRLVGLVLCSNASMVYFALDSLRVAVVTTLACSLLLQAGYFGCVLFFADVDDL
>CP034451|3841035:3930624|3855994_3856834_-|AZO10874.1|DBSCAN-SWA
MPSQISQVPAISPVSIRERIGSINTAEIISVLKGELTALHIKQAFSTEVAEKITTNFVGSAGLKERNDGVPGQYVGASHYRKDAASYFADAEKARPHVEALFENLVDPVRAIFGALKRELHNKGIELRLARSEHGQANVCRALSWSGTGTFSLAPHDDVAQVLCAGNDYELSAVAHNTVAAFNFYPSIPEEGGNLRLWSHKPTVIDRKSQGVETTGYPYSAAYLEAVPCRDFQLKAGDIALIDGGFVHGVTGRSGDGKRRLVLNCFFGFARPDLVLWWT

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZO10862.1|3841035_3841200_+|transposase	IS110 family transposase	NA	NA	NA	NA
AZO10863.1|3841846_3842281_+	Lrp/AsnC family transcriptional regulator	NA	NA	NA	NA
AZO10864.1|3842598_3842820_+	hypothetical protein	NA	NA	NA	NA
AZO10865.1|3842829_3842952_+	hypothetical protein	NA	NA	NA	NA
AZO10866.1|3843530_3845009_-	NAD-dependent succinate-semialdehyde dehydrogenase	NA	NA	NA	NA
AZO10867.1|3845302_3846547_-	aspartate aminotransferase family protein	NA	NA	NA	NA
AZO10868.1|3846804_3848163_-	MmgE/PrpD family protein	NA	NA	NA	NA
AZO10869.1|3848815_3849844_-	L-histidine N(alpha)-methyltransferase	NA	NA	NA	NA
AZO10870.1|3851515_3852544_+|transposase	IS110 family transposase	NA	NA	NA	NA
AZO10871.1|3852918_3853065_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
AZO10872.1|3853089_3853245_+	hypothetical protein	NA	NA	NA	NA
AZO10873.1|3853198_3853657_+	hypothetical protein	NA	NA	NA	NA
AZO10874.1|3855994_3856834_-	hypothetical protein	NA	NA	NA	NA
AZO10875.1|3856826_3858083_-	diaminobutyrate--2-oxoglutarate transaminase	NA	NA	NA	NA
AZO10876.1|3859141_3859984_-	radical SAM/SPASM domain-containing protein	NA	NA	NA	NA
AZO10877.1|3860827_3861574_-	LuxR family transcriptional regulator	A0A1I9KF49	Aeromonas_phage	8.4e-18	28.2
AZO10878.1|3862211_3864014_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	3.2e-39	29.6
AZO10879.1|3864611_3864818_-	hypothetical protein	NA	NA	NA	NA
AZO13080.1|3864814_3865129_-	ferredoxin III, nif-specific	NA	NA	NA	NA
AZO10880.1|3865128_3865332_-	hypothetical protein	NA	NA	NA	NA
AZO10881.1|3865378_3865816_-	DUF269 domain-containing protein	NA	NA	NA	NA
AZO13081.1|3866139_3867297_-	TlpA family protein disulfide reductase	NA	NA	NA	NA
AZO10882.1|3867896_3868910_-	1-aminocyclopropane-1-carboxylate deaminase	NA	NA	NA	NA
AZO10883.1|3869146_3869446_-	hypothetical protein	NA	NA	NA	NA
AZO10884.1|3869978_3870659_-	DUF269 domain-containing protein	NA	NA	NA	NA
AZO13082.1|3870742_3871888_-	TlpA family protein disulfide reductase	NA	NA	NA	NA
AZO10885.1|3872507_3873707_-|transposase	IS256 family transposase	A0A220NQR7	Corynebacterium_phage	8.0e-95	47.1
AZO10886.1|3873985_3875284_-	lysine N6-hydroxylase	NA	NA	NA	NA
AZO10887.1|3875635_3876493_+	GntR family transcriptional regulator	NA	NA	NA	NA
AZO10888.1|3878649_3879180_-	hypothetical protein	NA	NA	NA	NA
AZO10889.1|3880046_3881225_+	M24 family metallopeptidase	NA	NA	NA	NA
AZO10890.1|3886455_3888117_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
AZO13083.1|3888204_3889158_+	ABC transporter permease	NA	NA	NA	NA
AZO10891.1|3889154_3890033_+	ABC transporter permease	NA	NA	NA	NA
AZO10892.1|3890025_3892080_+	ABC transporter ATP-binding protein	G3M9Y6	Bacillus_virus	3.3e-08	27.1
AZO10893.1|3892880_3893774_+	polysaccharide deacetylase	NA	NA	NA	NA
AZO10894.1|3897915_3899394_+	NAD-dependent succinate-semialdehyde dehydrogenase	NA	NA	NA	NA
AZO13084.1|3899615_3901049_-	amidase	NA	NA	NA	NA
AZO10895.1|3902352_3903450_+	DUF2817 domain-containing protein	NA	NA	NA	NA
AZO10896.1|3903800_3904943_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
AZO10897.1|3904927_3906691_+	ABC transporter permease subunit	NA	NA	NA	NA
AZO10898.1|3906729_3907911_+	aminopeptidase P family protein	NA	NA	NA	NA
AZO10899.1|3907904_3908993_+	ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	3.7e-22	36.4
AZO13085.1|3909159_3909513_+	RidA family protein	NA	NA	NA	NA
AZO10900.1|3909499_3911566_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
AZO10901.1|3913048_3913393_-|transposase	transposase	A0A0P0ZDM8	Stx2-converting_phage	2.4e-36	62.6
AZO10902.1|3913484_3913826_-	hypothetical protein	NA	NA	NA	NA
AZO10903.1|3913975_3914764_-	FadR family transcriptional regulator	NA	NA	NA	NA
AZO13086.1|3914777_3916214_-	FAD-binding oxidoreductase	NA	NA	NA	NA
AZO10904.1|3916422_3917508_+	DUF2817 domain-containing protein	NA	NA	NA	NA
AZO10905.1|3917657_3918803_+	ABC transporter substrate-binding protein	NA	NA	NA	NA
AZO10906.1|3918907_3919234_+	hypothetical protein	NA	NA	NA	NA
AZO10907.1|3919221_3919476_+	ABC transporter permease subunit	NA	NA	NA	NA
AZO10908.1|3919579_3920536_+	D-2-hydroxyacid dehydrogenase	M1NSB9	Streptococcus_phage	4.3e-19	27.0
AZO10909.1|3920529_3921150_+|transposase	IS6 family transposase	NA	NA	NA	NA
AZO10910.1|3923323_3924484_+	hypothetical protein	NA	NA	NA	NA
AZO10911.1|3926492_3927749_+	ATP-grasp domain-containing protein	NA	NA	NA	NA
AZO10912.1|3929067_3930624_+|transposase	IS66 family transposase	A0A0P0ZEB3	Stx2-converting_phage	1.1e-101	40.8

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>CP034451|5814299:5822590|DBSCAN-SWA
GATGGACCGTCTGTGGGCCGAGAATGACGATTCACGCCTTACCGGCGATCCATCGCTGGTGGTGGACGTCGCCGGCTTTGAAGGACCGCTCGATCTTCTCCTGCATCTGGCGCGCAACCAGAAGGTCGACCTTGCGCGAATTTCCATCCTGGCTCTCGCCGAGCAGTATCTGGCCTTTATCGAGAAGGTGAGGGCGCTGAGACTGGAATTGGCGGCCGACTACCTGGTGATGGCGGCCTGGCTTGCCTTCCTCAAGTCGAAGCTTCTGATCCCGAAGCAGCCCGGCGAAGAGGGCGAGAGCGGTGAGGAACTGGCGGCGGTGCTGCAGTTCCGGCTGAAGCGGCTGGAAGCCATGCGCGATGCCGCCGCGAGGCTGGTCAACCGCAACCGGCTCGGACGCGACGTCTTCGCGCGCGGCATGCCTGAAATGGTGATCGTCGAAAAGCGCAACGCCTATTCGGCCTCGCTCTACGATCTGTTGACCGCCTACGCACAACAGCGCCAGAGGCAGGCGATCAACAATGTGACGATCGCCAGGCGCGCCGTCTGGTCGCTGAAGGATGCGCGCCAGGTGCTGGCAAGGCTGGTCGGCACGTTGAGCGACTGGACCGCGTTGGACAGCTTCCTCATCGAATATCTGGCGAGCCGGGAAGAAACCCGCACGGCGGTCGCAAGTTCCTTCGCGGCGACGCTCGAAATGGTGCGCGAGGGCAAACTGGAAGTGCGGCAGGATCAGGTTTTCGCGCCAATTTACCTGCGCGGCCGCGCGCAAGGGGTCAGGGCAGTCGAGGTGGTCTCATGAGCGAACGCGCCAATGCTTCGGTCATCCCGTTCAAGGTCGAAGACGAACCCGAGGACGAGATGGTCGAACAAGGTTCCATCGAGAACCCTGCCGAACGGCTGCAACTGGCGGAGGCCGTCCGCATGGCCGAGGCGATCGTCTTCGCCAGCGCGGAGCCTGTAAGCGAGAAACAGCTCACGGCGCGCCTTCCGGAGGGGGTCAATATCGCGGCGGCAATGGCCGACCTGCAGGAGATCTATTCCAAGCGCGGGGTCAATCTGGTTCGCGTCGGCGATGCCTGGGCGTTCCGGACCGCGGGCGATCTCGCCTTCCTGATGAGCCGGGACACGGTGCAGCAGCGAAAGCTTTCGCGCGCGGCACTCGAGGTGCTGGCGATCATCGCCTATCACCAGCCGGTGACGCGTGCCGAGATCGAGGACATCAGGGGCGTCGAGACCTCGAAGGGGACGCTGGACACGCTGCTGGAGACGGAATGGGTCCGGATGCGCGGACGCCGCCGCACGCCCGGCCGCCCGGTGACCTACGGCACGACCGACGCTTTCCTCGACCATTTCGCGCTTGAGGAAATCCGCGATCTGCCCGGCATGGAAGAACTGAAGGGCGCCGGCCTGCTGTCGACGCGCATGCCGTCCAATTTCTCGATACCGCTGCCGCCGGCCGATCCCGAGGCGCTCGCAGAAGACGAAGATGCGCTGACCGATATCGACCTCGAGGAACTGGGGCTGCTGACCCCGCGCGTCACGGAAGACTGACGCAAAAAAGCCGCTGTTCGGTCGTTAACGGCAGGTGTGCGCGGATTCGTAGCAAGCTGCTCACGCCGAAAATGCGTGACATCCGCCAGCCATTTTATCAACTTCACTGCAGTTGTGTTTGAATCCCTAAGCGAAAACGCATAGATCATCGCCAGGGAAAACATTCGAGAGAGATGTGCAATGGGTTCACTATCGATATGGCACTGGCTGATCGTGCTGGTCATCGTGCTGCTGCTGTTCGGCCGCGGCAAGCTGCCGGAGCTGATGGGCGACATGGCCAAGGGCATCAAGAGCTTCAAGAAGGGCATGGCCGACGACGACACCGCCGAGGACAAGCGTACCGTCGAGCATCGCGCCGACGAGACCGTTTCGCCGGGCAAGGAAAAGGTCAGCAAAAGCTGAGCTCGGTTGTTGCTTTGTGCATGTCGTTGTCCCAAAACCGCTTCGAACTTTTGGGCGACATGCACTAGTCGGAATAAATAGCCATGTTTGAAGTCGGCTGGACCGAAATGCTGGTGATCGCGGTCGTCATGATCGTGGTCGTCGGGCCTAAGGATTTGCCCAACATGCTGCGCACCTTCGGCCGCACGACGTCGAAGTTGCGCGCCATGGCCGCCGATTTCCAGAAGCAGTTCAACGAGGCTTTGAAAGAAGCCGAACTCGACGACGTCAAGAAGTCGGTGGACACGTTGAGAGGCCTCAACCCGGCGACTGAGATCCGCAAGCAGCTCAATCCGTTCGAGCAGGCCGCGGCGGATGTTCGCGCCGGCGTCGACACGATGATGAAGCCCAAGCCCGCCGCGGATCCGGCACAGGAGGCCGCGGCGACGCCGGAAGCTGCGGAGCCGCTCAAGAACGGCGCGACCGAAATGCCCGGTATCAACGGAGCTGAGGTGACGCCGGCCACGCCAACCTTCCCGGTCATGACAGACGCTTCGGTGACCGCGCCGGTTTCGGAAATCGCCAAGCCCGCGGAGCCGGCCAAAAAGGCGGCGACATCCAAGGCGAAGACAGCTCCCGGCGTGGCGAAAGCGACAACGGCCAAGGCGCCGGTCGCGGCCGCCTCTGCAAAGGCCTCGCCGGCGGCAAAGGCTGCAACGCCAGCCAAGAAGGCAGCGCCCAAAGCAGAGCCCAAAGCGGTGGCCACGGTCAGGAAGCCAGCCGTGAAAAAGCCCTCTGATGCCAAGAAGACGGCGGGAGCCGCCAAGTGAGCGTTTCGGATCAGGAAAGAGATGAGATCGAGAAGTCCTCGGCGCCGCTGATCGAGCATCTCATCGAGCTGCGCCGCCGGCTGATCTGGTCACTCGGCGGCTTTTTCATCGCCTTTCTCGCGTGCTTCTTCTTCGCCAAGCGGCTCTTCAACCTACTGGTCATACCCTTCAAATGGGCGACACAATGGGCCGGGCTCGATCCGCATAAGGTCGAGCTGATCTACACCGCGCCGCAGGAGTTCTTCTTCACCCAGGTGAAGCTCGCCATGTTCGGCGGCATGGTCATCGCGTTCCCGCTGATCGCCACCCAAATCTACAAATTCATCGCGCCAGGCCTCTACAAGAATGAGCGCAGCGCCTTCCTGCCGTTCCTGATCGCATCGCCCATCTTGTTCCTGATGGGCGCCTCGCTGGTCTATTTCTTCTTCACCCCGATGGTGATGTGGTTCTTCCTCGCCATGCAGCAGGTCGGCACCAACGACCAGGTGCAGATTTCGCTGCTGCCGAAAGTGTCGGAATATCTCAGCCTGATCATGACGCTGATCTTCTCCTTCGGCCTGGTGTTCCAGCTGCCGGTAGTGACCAGCCTGCTGACGCGTGTCGGCCTGCTGTCGTCGAGGGGACTGGCGGAAAAGCGCAAATGGGCGATCGTCATCGCCTTCGTCGTCGCCGCGGTGCTGACCCCGCCCGATCCCATGAGCCAGATCGGCCTCGCGATTCCGACCATCCTGCTCTACGAGGTCGCCATCTTCTCCTCGCGCCTAATCGAGCGCAACCAGGAGCGCGACCGCTTGGCGCGTGAGCGGAAAGAGAGCGCAAGCACGGTCGCCGACAAGGCGCCGGACGCGTCCTCGAGCTGATCGCCACATCGGGAAAGCCGGAAAAACGCCGCAGCCGCGGCCGCCTGTCTTGCATCAATCAAGGATGCGGTTTACGCCCTCTGGCCTGAAATGCGTCGCCTCATGCGATGCGTTTCAGCTTTTGTTTTGAGCATGTCGCTGTCCCAAAATCGCAATGCATTTTTGGGCGGCATGCTTAGCCGAGGACCGACAAACCATGCTTGATATCAAATGGATTCGCGACAACCCGAAGGCTCTGGTCGAAGCGCTCGTGAAGCGCTCGTGGTCGGCCGGTGAGGCGCAGTCCACCGTCGACGAGCTGATCGCCAGGGACGAAGCGCGGCGTGCGCATCTGAGCGAATTGCAGGTCAAGCAGGAGCGTCGCAACGCCGCCTCGAAAGAGATCGGCAACGCGATGCGATCGGGCGATGCGGCGCTTGCAGAAAAGTTGAAGGCCGAAGTCAGCGAGATCAAGGCATTCATCCAGAATGGCGAGGCACGCGAGCGCGAGCTCGACAAGGCGCTGAACGACGGGCTAGCGGTGCTGCCCAACGTACCGCTCGACGACGTTCCCGTCGGCAAGGACGAGCACGACAATGTCGTCAAGCGCATCGTCGGCGAGGTGCCGCCGCGCCCGAACTGGGTGAAGGAGCATTTCGAGATCGGCGAAGCTCTCGGCATGATGGATTTCGAGCGGGCGGCGAAGCTATCCGGCTCGCGCTTCACGGTGCTGAAGAGTCAGCTCGCCCGCATGGAGCGCGCGCTCGGCCAGTTCATGCTCGACCTGCACACCGCCGAGCATGGGTATGAGGAAATCCAGCCGCCGCTGATGGTACGCGACGAGGTGCTTTTCGGCACCAACCAGCTGCCGAAGTTCGAACTGGACCTCTTCTTTACCCCGCATGGGGACGGGCGCCTGGGACTTATTCCGACGGCCGAAGTGCCGCTCACCAACCTCGTGCGCGAGGAGATCACGGCGCACGAAAGGCTGCCGCTGCGCTACACCGCGCTGACGCCATGCTTCCGCTCGGAGGCGGGCTCGGCGGGGCGCGACACGCGCGGCATGCTGCGTCAGCACCAGTTCTATAAGGTCGAGCTGGTCTCGATCACCGACCAGGAGAGCTCGCTTGCCGAGCACGAGCGCATGACCCAATGCGCCGAAGAGGTGCTAAAGCGGCTCCGCCTGCCGTTCCGCACGGTGACGCTCTGCACCGGCGACATGGGGTTCGGCGCACGCAAGACCTACGACATCGAGGTCTGGCTGCCGGGTCAGAACGCCTATCGCGAGATCTCGTCCTGCTCGGTGTGCGGCGACTTCCAGGCCCGGCGCATGGATGCCCGCTACAAGGACAAGGACGGCAAGGGCAACCGCTTCGTGCATACGCTCAACGGCTCGGGCACTGCGGTCGGCCGCGCGCTTATCGCGGTCATCGAAAACTACCAAAACGAGGACGGCAGCGTAACCATTCCTGAAGCGCTTCGGCCTTACATGGGTGGTCTCGCGAAGATCGAATCCAAATGAGCTCATGCGCATCCTGCTGACCAATGATGACGGCATCCATGCCGAAGGGCTGGCGTCGCTGGAGCGCATCGCCCGGACGCTGTCGGATGACGTCTGGGTGGTGGCACCGGAGCAGGACCAGTCCGGCTACGCCCATTCACTGTCGATCTCGGAGCCGCTCAGGCTGAGGAAGATCGGCGAAAAGCACTATGCCGTGCGCGGCACGCCGACCGACTGCGTCATCATGGGCGCGAAGAAGATACTGCCCGGGCCGCCGGATCTCATCCTGTCGGGCGTCAATTCCGGCGCCAACATCGCCGACGACGTCACTTATTCGGGCACCGTCGCGGGCGCCATGGAAGGCGCGCTGCTCGGCGTGCGCTCCATCGCCGTCAGCCAGGCTTATTCCTACGTCGGCGAGGACCGCGTTGTCCCCTACGAGACGACCGAAGCGCTGGCGCCGGCACTGCTGAAGAAGCTGATTGCGACGCCGTTGCCGGAAGGGGTGCTGCTCAACGTCAATTTTCCGAACTGCGCGCCCGACGAGATCGAAGGGACGGTCGTCACCTCGCAAGGCAAGCTGGTGCACAGCCTGTGGGTCGAAGAGCGGCGCGACGGGCGTGGCTTGCCTTATTACTGGCTGCGCTTCGGCCGCGAGCCGGTCGAAGGCAAGAAAGGCACCGACCTTCACGCGATGCGCAATCGGCTGGTGTCGGTGACGCCGCTGCAGCTTGACCTCACCGCCCATGAACTCCGCGACCAGCTGACCAAGGCGCTCTCATGAACATGGCCCTCGACGACCGCGAAGGATTTGCTGCTTTCCTGCTTCGCCTGCGCGGCCGGGGCACTGCGCCGAAGCCGCTGGTCGCCGCTTTCGAGGCGACGCCGCGGCGCGGCTTCCTGTCTGCGCAGTTCCATTCGATCGCCTGGTCGGAAGGCATGCTGCCGATCGACTGCGGCGAGGCGATCGAGGGCGCGGACCTGCAGGCGGCGGTGCTCGCGGCGCTGGCCATCGAGCCGGGAAACCGCGTGCTCGAGATCGGCACCGGATCGGGCTACACCGCTGCCGTGATGTCGCGGCTGGCCGCCCGCGTCGTCACCATCGACCGCTACAAGACCCTGACCGAACAGGCAAAGCAGCGCTTCGAGGCGCTGGGCATCAGCAACGCCATCGCGCGCCAGGCAGATGGCTCCAACGGCCTGGCCAATGAAGGGCCGTTCGACCGCATCCTCGCCTGGGCTGCTTTCGACAGCCTGCCGCGCTTTCTGCTCGACCAGTTGTCGAGCGGCGGCATCGTCATCGCGCCGATCGGCCCGGAAGAGGGCGAGCAGGTGCTGGCCAAGCTGACCAAGGTCGGCAGCCGTTTCGAACGCGAGGACATCGGCATGGTCAGGCTGCAGCCGATATTGCGAAGCGTCGCCGCGGTGATTTAGCCGGGTTGGATTCATGGGAGGCCAGCCGGCAACTGGCGGCTTCCACGCTTCCGATGCTCACGTCACGCTCCGCTCTCGTCTCCGGCTGACCTGAATCTCGGCCCACCGCCTCCGATCGAAAATGTTTTAAGAAAATTTTTGACGGATTCTAATGGGTTAACCGGCCAGTAACATTAACGCGCTTTAATCATGACCAGTTTGTACCGGGTCTGTGCGGGTTAGTGCGATGCAATTCAATGTTTTGAAGGCAAACGGACGGAATCTGGCGCGTGGCTGCGCCGTCCTCGTGATCGCCGGCGCCGCCGCCGGCTGCAGTTCCCAGGCCATGCGCTTCAACGGCGTCGACGACGTTTTCACCTCATCGACCAACAATCAGCGCGCCATCATCGACAAGCAAAATGTCGATCAGCCCTATCCGGGCGACACGGTCGCGCCGGCCCCCGTCGACGGCAGCCACACACAGTCGGTGAGTCGCTCGAGCCTCGAGCCGGTTACGGCACAGCAGTTGCCGCCACCCTCGGCGCCGGCCGCAGCGCCCGCCAAGCCGATGCGCACCGCCTCGGCGCCGACGCTCGCTCCTGCCGCGCCGCGTGTCGACAAGACGACCACCGGCACCGTCGCGCCGAAGCCGTTCAAGACCGCCGCCCCCGACGCCGTACGCAACGCAAGTGCGGCTTCGCACGCGACCGAGATTGTCGTCAGGGAAGGCGAGACCATTTCCGGTTTGGCGCGGCAATATCATGTACCGGCCGATGCGATCGTCAAGGTGAATGGCCTGGACGCCAAAAAGGGGCTGAGAATCGGTCAGAAGATCGTCATCCCCGCCTATGCCTATTCGAGAAAAGGTGAGCCCAGGGTTGCCGACGCCGCCAAGCCCGCCAACACGCCGAAGCCTGCCGGCGCGCCGGAGAAGGTCGCTGTGCTGCCGCAGCAGCCGAAGCTCAAGGATGGCAAGTCGGCTGCGCAGGTCGATGCATCCGCTGCGGCCAGCGGCTCGAAGAATGCCAAGCCCGCGCCACAGCTGGCCGACGCCAAGCCGGCCGGAGCCGGCGGCACCTATACCGTCCAGCAGGGCGACTCGCTGTCTTCGATCGCCCGCAAGACCGGTGTCGACGTCGCGGCGCTGAAGCAGGCCAACGGCATGGAGAACGGCCTGCTGAAGATCGGCCAGACCCTGAAAGTTCCTGCCGGAGGCACCGTCGCGATGGCCGCCGCCAAGCCGGCCGCGACGACCGGCGCGAAGCCGGCTGTCGATCCGGTGACGACGGCGACCACGCCGCCGCCGGCAAAGACCACGCCGTCTGAAACGCTCGCCTCCTACACACCGCCGAAAAAGGACAAGGTCATCCAGCAGGCCGAGGACGACGATGCCGTGGCGCCGGACGCGACCGGCATCGGCAAGATGCGCTGGCCGGTTCGGGGCCGCGTCATCTCCGGCTTCGGCGCCGGCAAAGACGGCGTCGACATCGCAGTGCCAGAGGGAACGCCGATCAAGGCGGCTGAGAACGGGGTGGTCATCTATGCCGGCGACGGTCTGAAGGAATTCGGCAACACCGTCCTGGTGCGCCACGAGAACGGCCTGGTCACCGTCTATGGTCATGCCAGCTCGATCGAGGTGCAGCGCGGCCAAAAGGTCAAGCGCGGCCAGGAGATCGCGGTTTCGGGCATGAGCGGCACGACGGACTCGCCGAAGCTGCACTTCGAGGTGCGCAAGAATTCGGCCCCGGTCGACCCATCGACCTATCTCGAATAG

Protein sequences of DBSCAN-SWA_2

>CP034451|5814299:5822590|5821063_5822590_+|AZO12495.1|DBSCAN-SWA
MQFNVLKANGRNLARGCAVLVIAGAAAGCSSQAMRFNGVDDVFTSSTNNQRAIIDKQNVDQPYPGDTVAPAPVDGSHTQSVSRSSLEPVTAQQLPPPSAPAAAPAKPMRTASAPTLAPAAPRVDKTTTGTVAPKPFKTAAPDAVRNASAASHATEIVVREGETISGLARQYHVPADAIVKVNGLDAKKGLRIGQKIVIPAYAYSRKGEPRVADAAKPANTPKPAGAPEKVAVLPQQPKLKDGKSAAQVDASAAASGSKNAKPAPQLADAKPAGAGGTYTVQQGDSLSSIARKTGVDVAALKQANGMENGLLKIGQTLKVPAGGTVAMAAAKPAATTGAKPAVDPVTTATTPPPAKTTPSETLASYTPPKKDKVIQQAEDDDAVAPDATGIGKMRWPVRGRVISGFGAGKDGVDIAVPEGTPIKAAENGVVIYAGDGLKEFGNTVLVRHENGLVTVYGHASSIEVQRGQKVKRGQEIAVSGMSGTTDSPKLHFEVRKNSAPVDPSTYLE
>CP034451|5814299:5822590|5816032_5816254_+|AZO12489.1|DBSCAN-SWA
MGSLSIWHWLIVLVIVLLLFGRGKLPELMGDMAKGIKSFKKGMADDDTAEDKRTVEHRADETVSPGKEKVSKS
>CP034451|5814299:5822590|5817059_5817923_+|AZO12491.1|DBSCAN-SWA
MSVSDQERDEIEKSSAPLIEHLIELRRRLIWSLGGFFIAFLACFFFAKRLFNLLVIPFKWATQWAGLDPHKVELIYTAPQEFFFTQVKLAMFGGMVIAFPLIATQIYKFIAPGLYKNERSAFLPFLIASPILFLMGASLVYFFFTPMVMWFFLAMQQVGTNDQVQISLLPKVSEYLSLIMTLIFSFGLVFQLPVVTSLLTRVGLLSSRGLAEKRKWAIVIAFVVAAVLTPPDPMSQIGLAIPTILLYEVAIFSSRLIERNQERDRLARERKESASTVADKAPDASSS
>CP034451|5814299:5822590|5820183_5820837_+|AZO12494.1|DBSCAN-SWA
MNMALDDREGFAAFLLRLRGRGTAPKPLVAAFEATPRRGFLSAQFHSIAWSEGMLPIDCGEAIEGADLQAAVLAALAIEPGNRVLEIGTGSGYTAAVMSRLAARVVTIDRYKTLTEQAKQRFEALGISNAIARQADGSNGLANEGPFDRILAWAAFDSLPRFLLDQLSSGGIVIAPIGPEEGEQVLAKLTKVGSRFEREDIGMVRLQPILRSVAAVI
>CP034451|5814299:5822590|5819428_5820187_+|AZO12493.1|DBSCAN-SWA
MRILLTNDDGIHAEGLASLERIARTLSDDVWVVAPEQDQSGYAHSLSISEPLRLRKIGEKHYAVRGTPTDCVIMGAKKILPGPPDLILSGVNSGANIADDVTYSGTVAGAMEGALLGVRSIAVSQAYSYVGEDRVVPYETTEALAPALLKKLIATPLPEGVLLNVNFPNCAPDEIEGTVVTSQGKLVHSLWVEERRDGRGLPYYWLRFGREPVEGKKGTDLHAMRNRLVSVTPLQLDLTAHELRDQLTKALS
>CP034451|5814299:5822590|5816337_5817063_+|AZO12490.1|DBSCAN-SWA
MFEVGWTEMLVIAVVMIVVVGPKDLPNMLRTFGRTTSKLRAMAADFQKQFNEALKEAELDDVKKSVDTLRGLNPATEIRKQLNPFEQAAADVRAGVDTMMKPKPAADPAQEAAATPEAAEPLKNGATEMPGINGAEVTPATPTFPVMTDASVTAPVSEIAKPAEPAKKAATSKAKTAPGVAKATTAKAPVAAASAKASPAAKAATPAKKAAPKAEPKAVATVRKPAVKKPSDAKKTAGAAK
>CP034451|5814299:5822590|5814299_5815100_+|AZO13202.1|DBSCAN-SWA
MDRLWAENDDSRLTGDPSLVVDVAGFEGPLDLLLHLARNQKVDLARISILALAEQYLAFIEKVRALRLELAADYLVMAAWLAFLKSKLLIPKQPGEEGESGEELAAVLQFRLKRLEAMRDAAARLVNRNRLGRDVFARGMPEMVIVEKRNAYSASLYDLLTAYAQQRQRQAINNVTIARRAVWSLKDARQVLARLVGTLSDWTALDSFLIEYLASREETRTAVASSFAATLEMVREGKLEVRQDQVFAPIYLRGRAQGVRAVEVVS
>CP034451|5814299:5822590|5815096_5815852_+|AZO12488.1|DBSCAN-SWA
MSERANASVIPFKVEDEPEDEMVEQGSIENPAERLQLAEAVRMAEAIVFASAEPVSEKQLTARLPEGVNIAAAMADLQEIYSKRGVNLVRVGDAWAFRTAGDLAFLMSRDTVQQRKLSRAALEVLAIIAYHQPVTRAEIEDIRGVETSKGTLDTLLETEWVRMRGRRRTPGRPVTYGTTDAFLDHFALEEIRDLPGMEELKGAGLLSTRMPSNFSIPLPPADPEALAEDEDALTDIDLEELGLLTPRVTED
>CP034451|5814299:5822590|5818119_5819424_+|AZO12492.1|tRNA|DBSCAN-SWA
MLDIKWIRDNPKALVEALVKRSWSAGEAQSTVDELIARDEARRAHLSELQVKQERRNAASKEIGNAMRSGDAALAEKLKAEVSEIKAFIQNGEARERELDKALNDGLAVLPNVPLDDVPVGKDEHDNVVKRIVGEVPPRPNWVKEHFEIGEALGMMDFERAAKLSGSRFTVLKSQLARMERALGQFMLDLHTAEHGYEEIQPPLMVRDEVLFGTNQLPKFELDLFFTPHGDGRLGLIPTAEVPLTNLVREEITAHERLPLRYTALTPCFRSEAGSAGRDTRGMLRQHQFYKVELVSITDQESSLAEHERMTQCAEEVLKRLRLPFRTVTLCTGDMGFGARKTYDIEVWLPGQNAYREISSCSVCGDFQARRMDARYKDKDGKGNRFVHTLNGSGTAVGRALIAVIENYQNEDGSVTIPEALRPYMGGLAKIESK

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZO13202.1|5814299_5815100_+	segregation/condensation protein A	A0A1B1IVW1	uncultured_Mediterranean_phage	9.2e-31	32.6
AZO12488.1|5815096_5815852_+	SMC-Scp complex subunit ScpB	A0A1B1IVT7	uncultured_Mediterranean_phage	5.4e-41	47.1
AZO12489.1|5816032_5816254_+	twin-arginine translocase TatA/TatE family subunit	A0A1B1IVR9	uncultured_Mediterranean_phage	3.9e-08	65.9
AZO12490.1|5816337_5817063_+	twin-arginine translocase subunit TatB	NA	NA	NA	NA
AZO12491.1|5817059_5817923_+	twin-arginine translocase subunit TatC	A0A1B1IVR7	uncultured_Mediterranean_phage	6.4e-46	45.1
AZO12492.1|5818119_5819424_+|tRNA	serine--tRNA ligase	A0A1B1IVT2	uncultured_Mediterranean_phage	2.8e-101	57.2
AZO12493.1|5819428_5820187_+	5'/3'-nucleotidase SurE	NA	NA	NA	NA
AZO12494.1|5820183_5820837_+	protein-L-isoaspartate(D-aspartate) O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	1.8e-16	38.5
AZO12495.1|5821063_5822590_+	LysM peptidoglycan-binding domain-containing protein	S6B1Q4	Bacillus_phage	7.0e-11	37.5