CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP025471	Pediococcus acidilactici strain PB22 chromosome, complete genome	2 crisprs	cas9,cas1,cas2,csn2,DEDDh,DinG,cas3,csa3	0	5	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP025471_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP025471_3

425623-426384

TypeII

Consensus_repeat	Method
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	PILER-CR
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CRISPRCasFinder
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CRT

11 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of CP025471_3

>merge|CP025471|3|425623-426384|PILER-CR,CRISPRCasFinder,CRT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCTTAATTAAGAAAGTTACTGTTGAAGAAATTGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCCAAGCTGGACCCATGTATGGTTGAGCAGCCGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCATAACGTTGCTAGCCACTGGTACAAGGTATGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCATTTTGGTTTCTAGGCTTTTCATTTTGACTGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCCCAGCGACGCTGATGTCTTGGCATGGGAATGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCTCGATAAGCACGATACTGAGCTAACCAGTCGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCGTAGGGTAACTGATGTTAGTAGCGTTATTTGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCCATTCGTTTGGCTATGTTTTCAGAATTTCTGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCTTGTTGACGCAGCCATATTTTTAAACCAGAGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCTACTATTCACTGCATCCCTACTGCAATACTGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCTTGCAAAGAGACAAAAAGCCTACAACCATGGTTTCAGAAGGATGTTAGATCAATAAGGTTAAGAAC

>CP025471|3|1|425623-426384|PILER-CR
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTAATTAAGAAAGTTACTGTTGAAGAAATT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CAAGCTGGACCCATGTATGGTTGAGCAGCC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ATAACGTTGCTAGCCACTGGTACAAGGTAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ATTTTGGTTTCTAGGCTTTTCATTTTGACT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CCAGCGACGCTGATGTCTTGGCATGGGAAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TCGATAAGCACGATACTGAGCTAACCAGTC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GTAGGGTAACTGATGTTAGTAGCGTTATTT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CATTCGTTTGGCTATGTTTTCAGAATTTCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTGTTGACGCAGCCATATTTTTAAACCAGA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TACTATTCACTGCATCCCTACTGCAATACT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTGCAAAGAGACAAAAAGCCTACAACCATG
GTTTCAGAAGGATGTTAGATCAATAAGGTTAAGAAC

>CP025471|3|2|425623-426384|CRISPRCasFinder
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTAATTAAGAAAGTTACTGTTGAAGAAATT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CAAGCTGGACCCATGTATGGTTGAGCAGCC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ATAACGTTGCTAGCCACTGGTACAAGGTAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ATTTTGGTTTCTAGGCTTTTCATTTTGACT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CCAGCGACGCTGATGTCTTGGCATGGGAAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TCGATAAGCACGATACTGAGCTAACCAGTC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GTAGGGTAACTGATGTTAGTAGCGTTATTT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CATTCGTTTGGCTATGTTTTCAGAATTTCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTGTTGACGCAGCCATATTTTTAAACCAGA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TACTATTCACTGCATCCCTACTGCAATACT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTGCAAAGAGACAAAAAGCCTACAACCATG
GTTTCAGAAGGATGTTAGATCAATAAGGTTAAGAAC

>CP025471|3|2|425623-426384|CRT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTAATTAAGAAAGTTACTGTTGAAGAAATT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CAAGCTGGACCCATGTATGGTTGAGCAGCC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ATAACGTTGCTAGCCACTGGTACAAGGTAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ATTTTGGTTTCTAGGCTTTTCATTTTGACT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CCAGCGACGCTGATGTCTTGGCATGGGAAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TCGATAAGCACGATACTGAGCTAACCAGTC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GTAGGGTAACTGATGTTAGTAGCGTTATTT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CATTCGTTTGGCTATGTTTTCAGAATTTCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTGTTGACGCAGCCATATTTTTAAACCAGA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TACTATTCACTGCATCCCTACTGCAATACT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTGCAAAGAGACAAAAAGCCTACAACCATG
GTTTCAGAAGGATGTTAGATCAATAAGGTTAAGAAC

Protein	Signature genes	Signature genes Name	Protein_function
CP025471.1\|AZP90174.1\|434438_435758_+\|DNA/RNA-helicase	unknown	unknown	gnl\|CDD\|226583
CP025471.1\|AZP90171.1\|430470_432303_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|372624
CP025471.1\|AZP90170.1\|428548_430171_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
CP025471.1\|AZP90161.1\|414464_415874_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
CP025471.1\|AZP90176.1\|436557_437112_+\|ribosomal-subunit-interface-protein	unknown	unknown	gnl\|CDD\|224461
CP025471.1\|AZP90168.1\|427404_428052_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
CP025471.1\|AZP90160.1\|413627_414272_+\|NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
CP025471.1\|AZP90162.1\|415900_418435_+\|peptidase	unknown	unknown	gnl\|CDD\|341064
CP025471.1\|AZP90167.1\|424922_425594_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
CP025471.1\|AZP90159.1\|411780_413334_+\|glutamine-hydrolyzing-GMP-synthase	unknown	unknown	gnl\|CDD\|234614
CP025471.1\|AZP90172.1\|432524_433700_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
CP025471.1\|AZP90177.1\|437260_439624_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
CP025471.1\|AZP90166.1\|424620_424926_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
CP025471.1\|AZP90173.1\|433767_434406_-\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
CP025471.1\|AZP90169.1\|428241_428526_+\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
CP025471.1\|AZP90175.1\|436042_436429_+\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
CP025471.1\|AZP90163.1\|418661_419243_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|370635
CP025471.1\|AZP90164.1\|419427_423522_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	mkCas0193_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
CP025471.1\|AZP91579.1\|409791_411708_+\|copper-translocating-P-type-ATPase	unknown	unknown	gnl\|CDD\|319774
CP025471.1\|AZP90165.1\|423737_424643_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851

Protein	Function_ID	Function_description	E-value
CP025471.1\|AZP90174.1\|434438_435758_+\|DNA/RNA-helicase	gnl\|CDD\|226583	COG4098, comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair].	4.47551e-172
CP025471.1\|AZP90171.1\|430470_432303_+\|APC-family-permease	gnl\|CDD\|372624	pfam13520, AA_permease_2, Amino acid permease.	2.74449e-28
CP025471.1\|AZP90170.1\|428548_430171_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
CP025471.1\|AZP90161.1\|414464_415874_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	2.60327e-49
CP025471.1\|AZP90176.1\|436557_437112_+\|ribosomal-subunit-interface-protein	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	2.37568e-37
CP025471.1\|AZP90168.1\|427404_428052_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	5.07026e-10
CP025471.1\|AZP90160.1\|413627_414272_+\|NAD(P)-dependent-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.29269e-42
CP025471.1\|AZP90162.1\|415900_418435_+\|peptidase	gnl\|CDD\|341064	cd09601, M1_APN-Q_like, Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1). This M1 peptidase family includes eukaryotic and bacterial members: the catalytic domains of aminopeptidase N (APN), aminopeptidase Q (APQ, laeverin), endoplasmic reticulum aminopeptidase 1 (ERAP1) as well as tricorn interacting factor F3. Aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease, preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is considered a marker of differentiation since it is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. ERAP1, also known as endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP), adipocyte derived leucine aminopeptidase (A-LAP), or aminopeptidase regulating tumor necrosis factor receptor I (THFRI) shedding (ARTS-1), associates with the closely related ER aminopeptidase ERAP2, for the final trimming of peptides within the ER for presentation by MHC class I molecules. ERAP1 is associated with ankylosing spondylitis (AS), an inflammatory arthritis that predominantly affects the spine. ERAP1 also aids in the shedding of membrane-bound cytokine receptors. The tricorn interacting factor F3, together with factors F1 and F2, degrades the tricorn protease products, producing free amino acids, thus completing the proteasomal degradation pathway. F3 is homologous to F2, but not F1, and shows a strong preference for glutamate in the P1' position. APQ, also known as laeverin, is specifically expressed in human embryo-derived extravillous trophoblasts (EVTs) that invade the uterus during early placentation. It cleaves the N-terminal amino acid of various peptides such as angiotensin III, endokinin C, and kisspeptin-10, all expressed in the placenta in large quantities. APN is a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs are also putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	0
CP025471.1\|AZP90167.1\|424922_425594_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	4.35798e-102
CP025471.1\|AZP90159.1\|411780_413334_+\|glutamine-hydrolyzing-GMP-synthase	gnl\|CDD\|234614	PRK00074, guaA, GMP synthase; Reviewed.	0
CP025471.1\|AZP90172.1\|432524_433700_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	3.97227e-87
CP025471.1\|AZP90177.1\|437260_439624_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
CP025471.1\|AZP90166.1\|424620_424926_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	9.86823e-29
CP025471.1\|AZP90173.1\|433767_434406_-\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	4.94982e-58
CP025471.1\|AZP90169.1\|428241_428526_+\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	1.42388e-45
CP025471.1\|AZP90175.1\|436042_436429_+\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	1.46619e-22
CP025471.1\|AZP90163.1\|418661_419243_-\|hypothetical-protein	gnl\|CDD\|370635	pfam09726, Macoilin, Macoilin family. The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.	0.000198744
CP025471.1\|AZP90164.1\|419427_423522_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	2.51659e-144
CP025471.1\|AZP91579.1\|409791_411708_+\|copper-translocating-P-type-ATPase	gnl\|CDD\|319774	cd02079, P-type_ATPase_HM, P-type heavy metal-transporting ATPase. Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.	0
CP025471.1\|AZP90165.1\|423737_424643_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	8.56219e-97

>CP025471.1|AZP90167.1|424922_425594_+|type-II-A-CRISPR-associated-protein-Csn2
MKLTYRTHEPVEIKPHAITVLGTNNSTVYTDLVNGMQERNELILAFDENYKELEISKVFDWIGDVGTQDLVIQKYLTKIERVFAEGLVDEQRNQIHDQVNQLFNTIAEQLFMLDLPISVNYDFDLKKLLKYCGVHFDPLSVGNPYGIIEAVLKIHEECAINSCVVLTNVAHYLTATQIEELTQLVSQTNQALLLIEFTEIGNQEAYGNSEFYYIDNDFVDWHQ
>CP025471.1|AZP90166.1|424620_424926_+|CRISPR-associated-endonuclease-Cas2
MRLMIMFDLPVETAVQRKQYRQFRKALINEGFLMIQYSVYVRVCVNKKSPTFMENRIKTYLPENGTIQALTLTEKQYNDMHFLVGERVKDVRNTSDRTVIL
>CP025471.1|AZP90165.1|423737_424643_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRSVIITQHAKLSYSAHAMIVLTNDGINQIPVDDISLLLISTTQAVITTALISELSKKNVKIVFTDEAREPISEIYGYYPANRTAQLLREQVNWDLQLQQILWTKLVANKIINQINVLNLLDHSTDELVLELEKLELNDLTNREAVVAHKYFPLLFENGFTRRDGSVINAALNYGYSILLSAVNQEIVANGYVTYLGIHHDSEENQFNLASDLMEPFRPVVDCWVANQKFNQLTPDIKYGLVELLSLELKYNGKKTILRNAITDHVRNCLKYLAGKANSFTIEMELSDEVPNNAINDNV
>CP025471.1|AZP90164.1|419427_423522_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MGDRKYNLGLDIGTSSIGFAAVDENNQPIRVKGKTAIGVRLFEEGKTAADRRGFRTTRRRLSRRRWRINLLNEIFDAHLAEVDPTFLARLKESNRSNLDPKKSFQGSLLFPERKDYQFYEEYPTIYHLRKALMEKDRKFDFREIYLAVHHIIKYRGNFLNGTPMRSFKVENIELDTLFDQLNQLYAEIVPDNELAFDLAQVADVKDVLSSTTIYKMDKKKQLVKMMLLPASNKALQSENKKIVTQFVNAILNYKFKLDVLLQVETDADWSLKLNDEGADDKLEEFTGDLDENRLEIIDLLQRLHNWFSLNEITKDGNSLSAAMVEKYENHHHHLGLLKKVIENHPDAKKAKALKETYTAYVGKTDDKTQNQDDFYKAVEKNLDDSPDAKEIKRLIQLDQFMPKQRTGQNGAIPHQLHQQELDQIIEKQSKYYPFLAEPNPNVKRRKDAPYKLDELIAFKIPYYVGPLVTPEEQAQNGENVFAWMKRKAAGPITPWNFDEKVDRMESANRFIRRMTTKDTYLFGEDVLPAESMIYQKFVVLNELNNLKINGRHLSLKDKQDVYNDLFKQQKTVSIKALQNYYVTKKKAATAPTVGGLADPKKFLSSLSTYIDFKNMFGERVNDPQFQEDLEQIVEWSTIFEDRGIFKAKLQALGWLSEKQIQQLVAKRYKGWGRLSKKLLTGLKNAEGYSILDEMWRSTGNFMQIQSRPEFAALIQQANEKQFEGNDPDNVWENIENILGDAYTSPQNKKAIRQVVKVVQDIEKAVGNPPEKIAIEFTREAAANPQRTQSRLRTLEKLYESAEEVVDAGLTAELAEFKENKHVLSDKYYLYFTQLGRDVYTGDTISLDKLNDYDVDHILPQSFIKDDSLDNRVLTIRAVNNGKSDNVPAKMFGKKMGSFWRYLLDNGMISKRKYNNLITDPDNISKYAQKGFINRQLVETSQVIKLTANILNGIYDKDTEIIEVPAKMNSQMRKMFDLVKVREVNDYHHAFDAYLTIFIGNYLYKCYPKLQPYFVYDNFKKFGNKEDIGHKRFNFLGKIEREKKVVAPETGEILWSNVAPNETIKQIKKVYDYKFMIVSREITTRRAELFNQTVYPKNYHGKLIPIKEDRPTDLYGGYSGNTDAYLAIVALEDKKKGKYFKVVGIPTRVAAKLEKLKQQDSQQYLQALHKVIAPQFTKSTKKGIKKTEFEIVLDKVHYRQLVQDGPVKMMLGSSTYKYNAKQLVLSEKALQVIADDRKFDETQKDDNLIAVYDEILSIVNQSFDLYDINGFRKKLNDNRDQFIDLPAETKYEGRKVVAHGKREMILEILKGLHANAAFGNLKPIGFSTAFGQLQVPNGIILSKNAILIHQSPSGLFERKIKLSDL
>CP025471.1|AZP90163.1|418661_419243_-|hypothetical-protein
MKKIASIAILAVLPLTLASCGNHSTSNSDTSSNSSKTEKVAKSSSKSSASKDAKSSSADKATSSSASANSSKDSTNSNSSSNSNSASSSTSSATDSSSSADNQMSRSDLTKAEKKNGNRPLADEKIQNEQAAVALLTEKYGNQNWKVAFSSIGKSSPIYFHITSPKHGSYYVYANGDVQSADGDLSNHQIVNK
>CP025471.1|AZP90162.1|415900_418435_+|peptidase
MANIERFYTKFHPTNYQIKLAISRETKEIKGTTTITGEALSSQIDIHQKDLQIEELRVDGTAGDFTIDQAAEAIHVKLPHTGTVTLEIKYTTKLTDTMMGIYPSYYEVNGETKHLVGTQFETTFARQAFPCVDEPEAKATFDLAIKFDEHPGEVVLSNMPETKVEDGYHYFERTVKMSTYLIAFAFGDLQSKQTKTKSGVQVGVFATKAHQPQELDFALDIAKRAIEFYEDFYQTPYPLPHSWQLALPDFSAGAMENWGLVTYREAYLLLDPKNTTLRTKQVVATVIAHELAHQWFGDLVTMQWWDDLWLNESFANMMEYVAVDALEPDWQIWELFQNSEAGAALQRDATDGVQSVHVQVNDPAEIDALFDGAIVYAKGARMLVMVRALIGDDALRQGLQKYFASHQYGNAIGNDLWQALGEAANMPIGDIMHTWLDQPGYPVVTVQVENGDLVLEQQQFFIGEGQAQQRQWQIPLNGNYAEVPALLQTKTLNLGNYQDLRDRNQQPFRLNVGNSSHFIVRYDQRLLDDILADWEQLTAIDQLQLLQDLRLLAEGKQISYAEIVPLLPRFAKTDSALVTEMLYRVANDLKKFVAPQSSAEKQLKKFFGELSQAPAQRLGWQAAASETNDDQLMRPMVLKAALYAENPAVTAQAHQLFEENEAQLPKLPAAIRSLVIRNEVEHFGSPELFARLLKEYQRTSDASYKSDLCQALTATPSLPLIQQLVQQFENAQVIKPQDLRAWFRGVLANPQGQGSAWNWIRDEWQWLEDTVGGDMEFATYITVIAGIFQTSTRLAEFKAFFEPKLATPGLTREITMDIKVIETRVALIEIERDAVQAAVAQAIK
>CP025471.1|AZP90161.1|414464_415874_+|MFS-transporter
MEAQNTRHTNPMIVVAVVALMSFMGILTETSMNVTFPALMKEFHVPLNTVQWVTAGYLLMAALVMLTSAYMKRRFTNRQLFTAAAILFSSGDLICGLATNFWVLLAGRLIQAGCVGLCTPLMVNIILDVVPQHKLGTYIGMANLIILIAPALGPTFGGAVVAFNSWRMIFWSTLPVALVLMLLGMKVIKQYAPTDQHYAFDWTRFLLLGIALVSLIVGLNALGEMQLGTFVGLLIVSIGLTILFVKRSHTATKALFSLQVFKQPAFLYSFLPYIMLQFANVGINFLLPNYVQDVFQATSLVGGLILLPGSLFNGFGQPLYGWLLDRFGGKVPLYIGDILFTLALVGLMCWGPQLGVVGITIAYLIFAIGRSMAFGNSVAYGLKHIDKEFQNDANALYNTGQQVTGAIGTTVLALLMGSVKRPGYTHAQNVSAGSQLAFILLVIFGCVIFVFFHHLVNLKNLPEDKGVDL
>CP025471.1|AZP90160.1|413627_414272_+|NAD(P)-dependent-oxidoreductase
MAKIFIAGGSGRVATALIKNLVADGNEVVAGARHPENVVEMDHVNAVKLDLHDGVDAIADLMKGSDAVYFTAGSRGADLLQTDAMGAVKTMQAAEKLGIKRYVMLSSLYTLESERKWHEGGLADLLDYTTAKFFADNYLVHDTDLDYTIVQPTSLTEEAGTGQIYIGKELPQKTNPIPDVARVLADVLKQPNTVKKVFMMSSGSQAIDQALANV
>CP025471.1|AZP90159.1|411780_413334_+|glutamine-hydrolyzing-GMP-synthase
MANTDLSNFDKIIVLDFGSQYNQLITRRIREFGVYSELLSHKITAEEIKQINPKGIIFSGGPNSVYDDDAFRVDPEIYQLGIPILGICYGMQLMAYNLGGRVESADNREYGHADINVTDDQAALFKGLPATQTVWMSHGDLVREVPAGFKTVATSANCPIASMADDDRKFYGVQFHAEVRNTQYGNDILRHFAFDVCQAQANWSMNDFIDMQVEKIREEVGDRKVLLGLSGGVDSSVVGVLLNKAIGDQLVCIFVDHGLLRKGEAKQVMDSLEGKFGLNIIKVDAQDRFLSKLAGVTDPEQKRKIIGNEFIEVFNDEAQKLKGIDFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMHFELIEPLRTLFKDEARDLGEKLGMPEDLVWRQPFPGPGLGIRVLGEITEDKLQIVRDSDLILREEIKNAGLDRDIWQYFTVLPGIRSVGVMGDGRTYDYTVGIRAVNSIDGMTADFARIPWDVLQKISVRIVNEVDHVNRVVYDITSKPPATVEWE
>CP025471.1|AZP91579.1|409791_411708_+|copper-translocating-P-type-ATPase
MIKMQRWFTRFANPLLGVAALLTAVGWLLHHSGSFPEAAGMAYGIATLVAGMPILLKAIGALRARMASIELLVSIAVLGALIIGELEEAAMVTFLFGLGNYLERRTLKQTHRALANLTEMQPTQALLVSEGQTRTVAIDDVEVGDQLLVRIGDQVPVDGRVVTGTAAVDEAAITGEARVVNKTPTDQVYTGTIVENGQMVVEAQKVGEETTFGKIIELVEEAQDNQAPVSRFIDQFARYYTPLVLVLALLTQLVTQDFRLAITILVLACPGALVIGTPVSNVAGIGRGAQSGILIKGGQVIDQLAKVRTILMDKTGTITTGKPTVQSFYQYSQQDWLAVAAQLEKQTNHPLAVAVVEFYEQRTGQPVQNHDIAITTVKGIGVTATWHGHQVKLGSPRILEPSAQKLSNKQTADLQKLRENGQSVILMIVDGALVLTMGLSDQVRPGVASALKQLRQTGVTNQWMVTGDQLKVAQSVAHTVGITQVKAGQLPNEKAQFLKELQASGQPVLFVGDGINDSPAIAQAAVGIAMGSGTDVAIETSDVVLINPDFKNVVFARQIAQATLRNMMENVGIAVGTVALLMLGVSLGWVNMASGMFFHEVSILVVIFNAMRLLKLKRPAWENFSTKTGGESPSSKTI
>CP025471.1|AZP90168.1|427404_428052_-|CPBP-family-intramembrane-metalloprotease
MKISKSSLLTLITYLAIFLLPSVINLFVRLGASFIWVETIDYLVGAALLVVINLKNNEINQIETRRIPFFRAIAWGIIGTALVIVLQFVVSYVTFILGQNPASANTATLVTLAKINPFFVLAITVGAPIMEELVFRKVLFGNLSTLFGMRSNLGLTIMAIISSLAFAFMHNDSHIFLYAAIGLLFCWLYHKTGRIQTSMIAHILMNGLVVLPLVM
>CP025471.1|AZP90169.1|428241_428526_+|co-chaperone-GroES
MLKPLGDRVILEAKDEEEQTVGGIVLASNAKEKSQTGKVVAVGNGRVLDDGKTLPMNVKVGDTVVYDKYAGTEVTYEDQKYLVVHEKDLVAVVE
>CP025471.1|AZP90170.1|428548_430171_+|chaperonin-GroEL
MAKEIKFSEDARTKMLKGVDKLADTVKSTIGPKGRNVVLEQSYGSPTITNDGVTIAKSIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVNEGMKNVTAGANPVGIRRGIEKATEKAVAALHNMSHEVKTKDDIAQIASISSANPEVGKLIADAMEKVGNDGVITIEESRGVDTTLDVVEGMQFDRGYMSQYMVTDNDKMEANLDNPYILITDKKIANIQDILPLLQSVVEQSRSLLIIADDITGEALPTLVLNKMRGTFNVVAVKAPGFGDRRKEQLEDIAILTGGTVITDDLGLNLKDVTIEQLGQANKVTVTKDDTTIVEGSGSQEQIAERVAMIKQQISETTSDFDKEKLQERLAKLAGGVAVIRVGAATETELKEKKYRIEDALNATRAAVEEGFVPGGGTALVNVIASLEDLDAEGDELTGINIVRRALEEPVRQIAENAGEEGSVIVTKLKTQKDGVGYNAATDEWVDMIEAGIVDPTKVTRSALQNAASVSALLLTTEAVVADLPEEKPAAPAAPNPGMGGMM
>CP025471.1|AZP90171.1|430470_432303_+|APC-family-permease
MFSYLKRILIGKPLKTLDESGQALTKFKALALLSSDALSSIAYGTEEILSVLIVLSAAATWYSIPIAVIVLVLLFAITVSYRQIIKAYPSGGGAYVVASKNWGTSAGLVAGGSLLVDYMLTVAVSVTSGTEAITSAIPALQKYHVAIAVLIVLGIMALNLRGLRESASFLTIPVYLFVVVISIMIIVGLYNIVTGQVTYHAAAAIGSTVPGMTFVLFMRALSSGSSSLTGVEAISNAVPNFKKPRRKNAAATLAIMSLILASFFAGITFLAYYSGITPMSSQTVLSQIGVTVFGHGIFYYILQLSTALILAVAANTGFSAFPMLAYNLAKDKFMPHAYMDRGDRLGYSNGIISLAAGAIVLILIFGGQTGLLIPLYAIGVFVPFTLSQSGMIVHWKREGGAHWWINASANLLGALLSAVLVVCLLFLHFSNVWPYFVVMPLLLRMFYKIRKHYDEVADQLRVVEKGKVNLHDYDGSTVIVLVSNVTQVTSGAINYARSIGDYVIAMHVSFDANPEKEHKTAMEFKAEYPDVRFIDIHSSYRSITNPTLRFCDVIAKRAAERNYTTTVLVPQFVPRKPWQNILHNQTGLRLRAALNSRENIIVSTYNYHLK
>CP025471.1|AZP90172.1|432524_433700_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MRFEIVVSLFATMIISAILTPFVRRIAFKIGAVDKPNARRVNKVPMPTMGGLAIFLAFNFSLFFLLRNQIPNPQFYGIFFGECIIMLTGIIDDIFELKPSQKMIGILLAALAVYWFAEVQMTTLTLPFIGIVHLGWLSLPITLLWIAAITNAINLLDGLDGLATGVTIIALFTTGFTGLFFLPSTNIYIVIMIFTLVAAEVGFLPYNFFPARIYLGDTGALFIGFMIAVFSLSGLKNATFISVLIPVMILGVPLTDTIYAILRRLLNKQSIAHADKRHLHHRLMQMGLTHRQTVLVIYGISMIFSFIALLYPLSTLWGSVLLTIGILVGIELFVEAIGLVGENRTPMLSWIKRLVRTTTSKTASNEFKEEDTLKDRVRSRSERHQQKKHHD
>CP025471.1|AZP90173.1|433767_434406_-|YigZ-family-protein
MKLILSVKEPVTTEQDIKKSRFISRIIPVQTEEEAQTKLQDIREIEVKATHNCFAYVLGDHQDIQRASDDGEPSGTAGAPILEVLKRENLTNVLVVVTRYFGGIKLGAGGLIRAYGSSTSLAVQSATLMESVDQELLAITIDYQNNDQLTYYLEQHQITQVNHEYTTQVITTVAVDQDQVADLKAELTGLFSGNVSFKDGGQQRVQVPYHPQ
>CP025471.1|AZP90174.1|434438_435758_+|DNA/RNA-helicase
MEAKVKEKYYGRLVPVNQAEATDPTVNYFPAVIVKKRRIQCQRCGATTKLKEGSLPNQQYYCRHCINLGRMSTLVKLGNLPEPNHFPVGRSYLKWQGQLTPDQQRCANEIISSIKQQTDRLLWAVTGAGKTEMLFPGINFALKKALRVAIASPRIDVVLELHPRIQAAFPEIAIALLHGHTSTPYTYTQLVLCTTHQLLRFYHAFDVLIIDEVDSFPFAMNSALHYAAHQARKECGTTIYLTATPDGQLLKESRAHRLSTSYLTRRFHGYPLPEIKVVSGCNWQKLIHRQRLPERLRQFLMAQVKAQRQFLVFVPRIDQLSSVLQAIQKQFPELNLATVYAEDPDRIEKVSAMREGQLTGLITTTILERGVTFPGIDVAVLGADDEIFSMAALVQIAGRVGRSPKRPTGTVLFIGQMLTRRIKRAQRQIKFMNQQAFKQ
>CP025471.1|AZP90175.1|436042_436429_+|ComF-family-protein
MRKAFCNDFINFIQSLVKEDEHLVPIPVDQGTIKVRGFNQVAGLIEGLEFEPVLISQRSKQARHQFQRSRRERLQRENPFRVVEPNKVAGAKWVIIDDIYTTGVTVRQAGRELSKHGARQVRSITLCR
>CP025471.1|AZP90176.1|436557_437112_+|ribosomal-subunit-interface-protein
MLDFNVRGENIEVTESIRDYVEKRIGKIEKYFDQGANPKAHVNLKVYQDRTAKVEVTIPLPYLVLRAEETSPDLYASVDLVTDKLERQIRKYKTKINRKSRETGYKGVEIPQEDAREDEEEASEFDIVRTKQVSLKPMGAEEAILQMDMLGHNFFIYEDADTGSVDIVYRRHDGRYGLIESANE
>CP025471.1|AZP90177.1|437260_439624_+|preprotein-translocase-subunit-SecA
MANILKKWVESDAREIKRLGKKADKIDALKDEMAQLSDEELKAKTPEFKERLKNGETLDDILIEAFAVAREGAKRVLGLFPFRVQLIGGMVLHGGNIAEMKTGEGKTLTATLPVYLNALGGEGVHVVTVNEYLAERDSTEMGELYKWLGLTVGVNTAEMSPDEKREAYNCDITYSTNSEIGFDYLRDNMVVYKEDMVQRPLNFALIDEVDSVLIDEARTPLIISGQTEPSVTLYQRADRFVKTLTDGDYTIDWESKSISLTENGIRRGEKYFNTDNLYDVENSALNHHIDQALRANYIMTKDKDYVVSDDGEVLIVDSFTGRVMEGRRFSDGLHQAIEAKEHVEIQDGSKTMANITYQNLFRMYKKLSGMTGTAQTEAEEFREIYNMEVVSVPTNRPVVRDDRPDLLYPTLESKFKAVVKEIKKLHTKGQPVLVGTVAVETSEYLSRLLDRERIPHVVLNAKNHAREAEIVANAGQKGAVTIATNMAGRGTDIKLGPGVVELGGLAVIGTERHESRRIDNQLRGRSGRQGDVGMSQFYLSLEDDLMIRFGSERIKDLLSRMKVADEDAVIQSRLISRQVESAQKRVEGNNYDARKNVLQYDDVMRAQREVIYAERQQVIMEEHSLKDVLMPMVYRTIDRVVDAHTAKTKKSYDLDTIVEFARTTLVNENDINIEDLEGKSANEIKDYLKQLADQMYKQKEDALYAPEQILEFEKVVILRVVDQHWTDHIDAMDQLRQSVGLRGYGQLNPLVEYQQEGYRMFNEMVTDIEYETTRLFMKSEIRQNLER

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Crispr_ID: CP025471_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP025471_4

621845-621948

Orphan

Consensus_repeat	Method
TTAGCTCAGTTGGGAGAGCATCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP025471_4

>merge|CP025471|4|621845-621948|CRISPRCasFinder
TTAGCTCAGTTGGGAGAGCATCTGCCTTACAAGCAGGAGGTCACAGGTTCGAGCCCTGTATCCTCCATTATCTTGAGCCGTTAGCTCAGTTGGTAGAGCATCTG

>CP025471|4|3|621845-621948|CRISPRCasFinder
TTAGCTCAGTTGGGAGAGCATCTG	CCTTACAAGCAGGAGGTCACAGGTTCGAGCCCTGTATCCTCCATTATCTTGAGCCG
TTAGCTCAGTTGGTAGAGCATCTG

Protein	Signature genes	Signature genes Name	Protein_function
CP025471.1\|AZP90343.1\|624795_625986_+\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
CP025471.1\|AZP90342.1\|623892_624624_-\|hypothetical-protein	unknown	unknown	unknown
CP025471.1\|AZP90339.1\|612985_614173_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340844
CP025471.1\|AZP90349.1\|633674_634394_+\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|211327
CP025471.1\|AZP90340.1\|614203_615220_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
CP025471.1\|AZP90346.1\|628266_628902_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
CP025471.1\|AZP90333.1\|606109_607087_+\|GMP-reductase	unknown	unknown	gnl\|CDD\|235479
CP025471.1\|AZP90347.1\|629308_631726_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
CP025471.1\|AZP90338.1\|612126_612900_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
CP025471.1\|AZP90344.1\|626161_627631_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|341045
CP025471.1\|AZP90348.1\|631981_633664_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
CP025471.1\|AZP90336.1\|610063_610330_+\|phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
CP025471.1\|AZP90341.1\|615265_616270_+\|lysylphosphatidylglycerol-synthetase-family-protein	unknown	unknown	gnl\|CDD\|377103
CP025471.1\|AZP90332.1\|605236_605491_+\|hypothetical-protein	unknown	unknown	unknown
CP025471.1\|AZP90337.1\|610329_612054_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
CP025471.1\|AZP90335.1\|609732_609921_+\|hypothetical-protein	unknown	unknown	unknown
CP025471.1\|AZP90350.1\|634500_635331_-\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576
CP025471.1\|AZP90345.1\|627710_628274_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|377744
CP025471.1\|AZP90351.1\|635456_635918_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180
CP025471.1\|AZP90334.1\|607309_609517_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616

Protein	Function_ID	Function_description	E-value
CP025471.1\|AZP90345.1\|627710_628274_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|377744	pfam06962, rRNA_methylase, Putative rRNA methylase. This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.	8.32952e-71
CP025471.1\|AZP90339.1\|612985_614173_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340844	cd03817, GT4_UGDG-like, UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.	9.2253e-139
CP025471.1\|AZP90340.1\|614203_615220_+\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	3.01195e-35
CP025471.1\|AZP90346.1\|628266_628902_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	2.39838e-47
CP025471.1\|AZP90333.1\|606109_607087_+\|GMP-reductase	gnl\|CDD\|235479	PRK05458, PRK05458, guanosine 5'-monophosphate oxidoreductase; Provisional.	0
CP025471.1\|AZP90347.1\|629308_631726_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
CP025471.1\|AZP90338.1\|612126_612900_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	6.63365e-30
CP025471.1\|AZP90344.1\|626161_627631_+\|MFS-transporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.35163e-65
CP025471.1\|AZP90348.1\|631981_633664_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.15648e-140
CP025471.1\|AZP90336.1\|610063_610330_+\|phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	7.13708e-55
CP025471.1\|AZP90341.1\|615265_616270_+\|lysylphosphatidylglycerol-synthetase-family-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	1.92078e-32
CP025471.1\|AZP90349.1\|633674_634394_+\|rRNA-pseudouridine-synthase	gnl\|CDD\|211327	cd02553, PseudoU_synth_RsuA, Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.	7.80634e-87
CP025471.1\|AZP90337.1\|610329_612054_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
CP025471.1\|AZP90343.1\|624795_625986_+\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
CP025471.1\|AZP90350.1\|634500_635331_-\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	3.79718e-74
CP025471.1\|AZP90351.1\|635456_635918_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	2.6924e-26
CP025471.1\|AZP90334.1\|607309_609517_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0

>CP025471.1|AZP90341.1|615265_616270_+|lysylphosphatidylglycerol-synthetase-family-protein
MILAGLVIFGYSLRGVNLHQVSHDILNLNVGWLLVALLCIILYLGFEAVATKVLVESNGDRLSWKDAIRIPLIEQLFNGLTPFSSGGQPAQLVALMQSGIEGGRASSVLLMKFVVFQSMVVLNFIFSLLIGFQYLEDKIKFLSWFVLFGFLIHLAVIIGLLMIMYWHNFTKKMFDLIFIPIKRFTKPERYLRWKTSIDAKVDTFYLESVRMKSQWRLLAKVALLTFLQLLFYYLIPYFILLALGKTHVHLIMVTCLHVLIFMVISLFPIPGGAGGAEYGFSVIFAQFVGNSSKLVLAMIIWRLLTYYFGMFAGMFATVIKPNRINRIVPKKTSE
>CP025471.1|AZP90340.1|614203_615220_+|glycosyltransferase
MPIKVNMFSSASKVKGQGVGSAYEELIRLLKTHFPKEIDLSINRYTQADISHYHTIDPQFFVSTFTKKRGVKVGYVHFLPETIEGSLKIPQPFRWLFYKYIIAFYKRMDQIVVVNPTFIDQLVKYGIKREIITYIPNFVRKDEFYQYDAEQRRQVREQLGVQDRFTILGIGQVQERKGVKDFIKLAQQHPEMYFIWAGGFSFGRLTDGYADLKKVVDNPPANLKFTGIVDRNKLVEYYNAADLFLLPSYNELFPMSVLEAFSCGTPVMLRDLDLYHSIIKGYYIAADNYAEMDQKLSALVKNPAQLRDYQQRADQASAEYSEDHLAEIWLNYYSSLLK
>CP025471.1|AZP90339.1|612985_614173_+|glycosyltransferase-family-4-protein
MNIGLFTDTYFPQVSGVATSIKTLRDQLEKQGHQVYIFTTTDPKVDTNVYERNVFRFTSIPFVSFTDRRIAISGFIRATQIAKELNLDIVHTQTEFSLGWMGKFVAKALKIPVIHTYHTMYEDYLHYVANGKLLKPYHVKQMTRAFCYHIDGIVAPSERVQRTIQRYGIQVPTRIIPTGVNLEQYQKDSNPQQCREALGYDAKTPVLLSLSRLAYEKNIQEVIDCFPAILKEVPDAQLLIVGDGPARTSLENQVHDLGLEKHVKFTGEINNDQVYRYYQAADLFVSASDSESQGLTYIEAMASHLKVVAKSGPYTDELLDDPSLGKVFDTEGQLVQAIKRYIEHPDEFNDPRPREKKLYEISADYFGKRIVDYYNSAISAHADLEHGSKKESELE
>CP025471.1|AZP90338.1|612126_612900_+|alpha/beta-hydrolase
MEFILKTGETIYYEDQGEGIPILFLTGFGGNTEIWSGQVNFFLQHGYRVIRLDYLNHGRSDRVDYDLKIGDLADEVLQLVDALEIKEPIGIGNSMGAAVLWNILSIRGWDFVSKAIFVDQSPRMMNDDQWHYGFKNLNEANFEQLMSEPILRPAYRRIEGYVYKNSKAIDSKYPFSQPKNRSLVKGHARKDWRPVLRAATKPVLFILGEKSPFFNPQMGDALKQLNSRIQVEVMSNVGHIPMAEEPAQFNQLVLRFL
>CP025471.1|AZP90337.1|610329_612054_+|phosphoenolpyruvate--protein-phosphotransferase
MTGTLKGIAASDGIAIAKAYLMVDPDLSFEKKTITDVDAEINRLHDALEQSKKELTLIKAKAAENLGAEEAEVFEAHLTILSDPELIGNIEDKIKNDTINAEEATKEVTDNFIAMFEAMTDNAYMQERAADIRDVTKRLMSHLLGVELPNPALIDSEVIIVAHDLTPSDTAQLDRRYVKGFITDIGGRTSHSAIMSRTLEIPAVVGSEKATTSVKQGDMMIVDGLTGDALINPSDDEIKEYEQKSADFKAQKAEWEKLKNERTVSKDGVHFDLAANIGTPDDLQGVLDNGGEAVGLFRSEFLYMNASELPSEDQQFEAYKKVVEGMNGKQVVVRTMDIGGDKDLPYLPLPEEMNPFLGYRAIRISLDRTDLFRTQLRALLRASAYGKLAIMFPMIATVAEFKKARAIYDDERQKMIDAGTKVGEIQVGMMMEIPAAAMIADKLAKYVDFFSIGTNDLIQYSFAADRGNEKVSYLYQPYNPSLLRLIKQTIDASHAEGKWTGMCGEMAGDQIAVPILMGLGLDEFSMSATSILKTRSLMKKLSTDDMKKLAEKAITEAETNKDVIKLVEETVNNK
>CP025471.1|AZP90336.1|610063_610330_+|phosphocarrier-protein-HPr
MEKRDFHVIAETGIHARPATLLVQAASKFNSDIQLTYKDKSVNLKSIMGVMSLGVGQGADVTISADGDDEADAIAALEDTMKKEGLSE
>CP025471.1|AZP90335.1|609732_609921_+|hypothetical-protein
MRDYLKLLNDLKDGVLDELTITAEEFQEFQPVFMDFPERKQLIGEAQRGGTITYRYENNKKQ
>CP025471.1|AZP90334.1|607309_609517_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MLCQNCHKNEATIHLYTNVNGRRTEVNLCQNCYQLLKNQQLNNNNGNGGARMAQDPFGFGNLDDIFRAMQGGNVSRPEDMYGQQVPPTQVGRGGGNNPNGGNGSPLLGQYGLNLTDLAKQGKIDPVIGRDKEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQRIVEGSVPQKLLNKQIIRLDVVSLVQGTGIRGQFEQRMQELMKEVQNNPDLIVFIDEIHEIVGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEEEAIKILKGIQKKYEDYHHVHYTDDAIVAAVKLSKRYIQDRYLPDKAIDLLDEAGSKKNLTINVADPETIQKKIDEAEAEKKKALESEDYEKAAYYRDQVSKLEKNKDGATNKEDEPTITAEDMEKIIESKTDIPVGDLQKQEQEQLQNLASNLKAHVIGQDEAVDKISRAIRRNRIGLNGTGRPIGSFLFVGPTGVGKTELAKQLADQLFGSKDAMIRFDMSEYMEPHSISKLIGSPPGYVGYEEAGQLTEQVRRHPYSLILLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGSGDVEADVGFGAAMQGKTHSVLDKLGNYFKPEFLNRFDDIVEFHALTKDNLMQIVDLMIADVNKMLATQGLHVNVTKPVEERLVELGYDPKMGARPLRRVIQEQIEDRIADFYLDHPSEKQLIARIKDDKIEVAPDDKK
>CP025471.1|AZP90333.1|606109_607087_+|GMP-reductase
MKVFDYEDIQLIPAKCVVRSRSECDPTVELGKHTFKLPVVPANMQTIINEEIAEKLAADGYFYIMHRFEPETRLAFVKKMKAKGLISSISVGVKDGEYDFIDELAAKNLVPDYITIDVAHGHAQTVIDMIHYIKEKLPESFVIAGNVGTPEGVRELESAGADATKIGIGPGKVCITKLKTGFGTGGWQLSALRWCAKVARKPLIADGGIRNHGDIAKSIRFGATMVMIGSLFAGHIESPGETKVEDGVTYKEYFGSASQYQKGEAKNVEGKKIWIHQRGHLADTLKAMQEDLQSAVSYAGGRDLESIRKVDYVIVKNSIFNGDIL
>CP025471.1|AZP90332.1|605236_605491_+|hypothetical-protein
MSKNLKIDLNTDELIGSREASLMWGKQKDYVRTIYNKYPERFPTGTIRKFGKQLIVTREGMESVTGIKYEDLDKKNIEKAKLPR
>CP025471.1|AZP90342.1|623892_624624_-|hypothetical-protein
MDKIKIPKINYHVDRKSYLPAILAVILTSTVWYFSSHFSSEPFKHNLTVQIIFFLASFMANFITFDQLTNKTNLRLIAPLAVIPVAFFIILLVSKERYVSLLGLLTLVPFISVFLPFQGKNGVGLISFAFSISVLSPIAFFYIRNAFVSSMFLKTCLLLCLVFLMILFSVFVAHPEQFIYLEIGLLVVITIFSFVLFKQWSAVLYPMIGILGWYLPRVKLPRNFILLVLIILICVTFLFTAGH
>CP025471.1|AZP90343.1|624795_625986_+|methionine-adenosyltransferase
MSERHLFTSESVSEGHPDKIADQISDAILDELLKNDPDARVACETTVTTGLVVVVGEISTTAYIDIQKVVRKTIKDIGYVGGEYGFDGENCAVIVAIDEQSPDIAQGVDDSLETREGHEDRLNRIGAGDQGLMFGYATDETKELMPLPIMLSHHLMQRIAKLRKEQVISYLRPDAKAEVTVEYDDNDQPVRVDTVVLSTQHDPDVTLEQIRKDVIEKVIKEVIPAELLDEKTNFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGAAHHGGGAFSGKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQIAYAIGVAEPVSVMVDTFGTGKVSEEALTKAVRQIFDLRPAGIIEMLDLKRPIYKQTAAYGHFGRTDVDLPWEKTDKVAELKAFFQK
>CP025471.1|AZP90344.1|626161_627631_+|MFS-transporter
MKKKQTNVALVTVAIFVATFMSAIEGTIVSTAMPTIVGDLHGVNLMNWVISIFLLTNAIFTPIYGKLSDIFGRKRVFIIGIIIFLIGSMLSGLAHSMTTLIIWRALQGIGAGSIMPVSNTIIADIYSLEKRAKVMGLNGSAWGIASIIAPLLGGFIVDNLSWHWIFFINVPIGIITIILIQLYLKEEVSVHRKKIDYWGSVWLMLSLLGLMYGFQLLGESTASKLILGLSFIIFVVAGALFIRQERRAEDPIIFLDLFNDRTFVIQNVATMLVSGLLIGFEVYLPTWTQGILGLPASLAGFAVTPSSVLWIFGSFLAGKMLVKLKANQILRISLTILAIGSFLLAVIPASTPFVAFFFIAAILGVGFGITITSTLVISQQLVSKDRIGVATSFNTLAKTLGQTIMMSVFGIIMNSTINMGIAHHPRINMTMMNQVINPQTAKQLPANLLPTLRDILYSALHNIYICGFILIIVAIVINAFSRPRTQKNK
>CP025471.1|AZP90345.1|627710_628274_-|methyltransferase-domain-containing-protein
MLDNAMQYSHRLLAEVVQPGDHVVDATMGNGHDTLFLANLVQSQGQVFSFDIQAAALSATEARLEKQLPDHQHVQLIQDSHDQLTQYVDTPISGAVFNLGYLPGGDKQIITHSASTIAAVQQCLQLLKVGGRVVLVCYYGHPGGAAELAKLLEFTANLDQHQFTCLRYEFINQVHQPPILLAIERRK
>CP025471.1|AZP90346.1|628266_628902_-|phosphatase-PAP2-family-protein
MRFKKFGWLILNWLPLLGLLTLVISVSNRWNWVHTYDRYLQKIIHGWQSPGLTPLVKIYTQLGNAKPFIFISIVILGMLLWRGFDRLAAFFLANVVLGNAINHLIKLWIQRPRPHFRLITIGGYSFPSGHSVAAMLLFGSLIFITTQTVCSPKWRISWILTCIILMLLLGLSRVYLNVHYPSDVTAGLLLGLVILQTTHWIFYRKKESQHA
>CP025471.1|AZP90347.1|629308_631726_+|leucine--tRNA-ligase
MAYNHKEIEPKWQRYWQKHETFKTVESEQKPKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRMKRMQGYKVLHPMGWDAFGLPAEQYAMKTGNNPKDFTAHNIKNFKRQIQSLGFSYDWSREVNTTDPEYYKWTQWIFEQLYKKGLAYEKETLVNWAPDLMGGTVVANEEVVNGKTERGGFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSIGASVFFDVEDSDQKIEIFTTRADTLYGATYLVISPEHPLVDQLTTLESKAAVEEYKQAVATKSDLERTDLNKDKTGVFTGSYAVNPVNGKKIPIWIADYVLASYGTGAVMAVPAHDPRDYEFARKFKIDIVPVIGGGNLDEEAYTGDGPHINSGFLDGLNKQEAIDKMLDWLEEHGAGHKKVNYRLRDWVFSRQRYWGEPIPVIHWEDGETTLVPEDELPLRLPATDNIKPSGTGESPLANLEDWLNVVDENGRKGRRETNTMPQWAGSSWYFLRYVDPKNQNKIADEDLLKEWLPVDLYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTLRLYEMFMGPLTESVAWSEEGLNGSRKWIERVWRLMIDDNNHLRDRITMINDHKLDLIYNQTVKKVTEDYENMRFNTAISQMMVFVNEAYKADALPMVYMEGLVKLLSPIVPHVAEEIWQIMGHEETITYEAWPTYDESKLVQDTVQVILQVNGKVRSKVEVEKDLDQAELEKIALADERIQQWTAEKDIKKVIVIPNKIVNIVAK
>CP025471.1|AZP90348.1|631981_633664_+|polysaccharide-biosynthesis-protein
MDKPSEFDTAESQYLGSQPLRENSGNSSSKAKMLEGSAWMTAGSIFSRILGAIYIIPWVIWFGVYSDQANALYTKGYNIYSFFLIAAIAGIPSAISKQVAHYNAINEFALGQRLYKRGLLLSVGTGVVCAAILFFGAPFLNDGDPNVTTVLHALAWAVLVIPTMSLTRGFFQGYQEMGPSAVSQFIEQLARVAYMLVTAYLIMYKNHGDWVYGVAQSTFAAFIGALGGLLVLIGYFVKYRRRLRYLSQHSVNGLAISTTSLYKEIIAQAVPFIIIGSAITIFQLIDQYTFFRIMRSVSDYSATVLNNMFAIFAFNANKLVMIVISLASALAVTSVPILSEAKTRGDRAEISRQVADSILLFAFLMIPSALGMAAVAQPAYTLFYHLSDVGTAILQFNSYVAIVLGLFTVISAVMQGIGENVLAVKYFVVGMIVKFIFQFPMVAIFSAVGSLISTAIGFAVVNWLILRHINREYGLDYDKINGFIGKIITYSFGTFFIAFVVTNGLYLVMNPANKVQALIVILVAATLGGLFYVVCVLKSRLADEIIGGRATGLRRMLKIK
>CP025471.1|AZP90349.1|633674_634394_+|rRNA-pseudouridine-synthase
MRVDKFLHDMNVGTRSQIRKLIKEKAVFVNDVVAKSGRVKVDPVVDQVRLGEQVITYQQYFYFMMNKPLGVVTATEDRKQKTVMDLFNKVDFRKDLFPVGRLDKDTEGLLLITNNGPLAHQLLAPERHVQKTYEAVVTGQITDPAVKQFADGIVLKDGTQLKPADLTILNYSALDEQTLVHVTLKEGKYHQVRRMFGSLGERVVSLKRISFGPLQLEEGLLPGTYRELSDEEIEKLKTE
>CP025471.1|AZP90350.1|634500_635331_-|NAD(P)H-hydrate-dehydratase
MLKINRQTLKSHWPVRQKQSHKGTYGHLLLIAGNAQYGGAGILAASAAIYAGGGLVTLATAKNNFTAVRATLAEIMLIDFTDFDQLSQSLANATGVVIGPGLGTDSTSLAVLNFTMAHIAEGVPLIIDGSAIDLVAQHDLRVSHHPTIYTPHQMEWQRLSGIKIADQSVERNQAVVDQLNATVVLKHYHTEIYAPAAPVAQIMAGNPGMATGGSGDSLTGILLALIAQANSVNEGVRLGTFLHSYTADLIYEHEAVVLPHRLICRLPAVLKQLSQP
>CP025471.1|AZP90351.1|635456_635918_+|universal-stress-protein
MDYKKILFGYDGSPESMAAFNRAVEIAKSNHAKLIIASVMKKQPANTASVSLGFGVIETGIDLQDTLDQWKTTLEKLKQDAQQQGLPAEDIEVVFKQGSPKSMLSYTLPKEYDVDLIVLGATGMGTVAQVILGSTASYVVENAAPDVVIVKNN

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP025471_3	3.4\|425857\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425857-425886	30	NZ_LR735422	Staphylococcus epidermidis strain none isolate Se_BPH0697 plasmid 2	941-970	4	0.867
CP025471_3	3.1\|425659\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425659-425688	30	MT774386	CrAssphage cr110_1, complete genome	78770-78799	5	0.833
CP025471_3	3.5\|425923\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425923-425952	30	MN693469	Marine virus AFVG_25M404, complete genome	41475-41504	5	0.833
CP025471_3	3.1\|425659\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425659-425688	30	NC_018486	Bacillus thuringiensis HD-771 plasmid p01, complete sequence	71581-71610	6	0.8
CP025471_3	3.1\|425659\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425659-425688	30	MH319723	Marine virus AG-345-D19 Ga0172267_104 genomic sequence	6296-6325	6	0.8
CP025471_3	3.4\|425857\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425857-425886	30	NZ_CP015439	Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence	215741-215770	6	0.8
CP025471_3	3.10\|426253\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	426253-426282	30	NZ_LT222315	Pseudomonas cerasi isolate Sour cherry (Prunus cerasus) symptomatic leaf plasmid p58T3	5481-5510	6	0.8
CP025471_3	3.10\|426253\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	426253-426282	30	NZ_LT222315	Pseudomonas cerasi isolate Sour cherry (Prunus cerasus) symptomatic leaf plasmid p58T3	71098-71127	6	0.8
CP025471_3	3.10\|426253\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	426253-426282	30	NZ_LT963397	Pseudomonas cerasi isolate PL963 plasmid PP2, complete sequence	119677-119706	6	0.8
CP025471_3	3.10\|426253\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	426253-426282	30	NZ_CP026561	Pseudomonas amygdali pv. morsprunorum strain R15244 plasmid p4_tig6, complete sequence	1134-1163	6	0.8
CP025471_3	3.10\|426253\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	426253-426282	30	NC_019292	Pseudomonas savastanoi pv. savastanoi native plasmid pPsv48C complete sequence	20895-20924	6	0.8
CP025471_3	3.1\|425659\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425659-425688	30	MN694191	Marine virus AFVG_250M444, complete genome	44594-44623	7	0.767
CP025471_3	3.1\|425659\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425659-425688	30	MN694065	Marine virus AFVG_250M443, complete genome	11492-11521	7	0.767
CP025471_3	3.4\|425857\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425857-425886	30	NZ_CP013684	Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence	70860-70889	7	0.767
CP025471_3	3.4\|425857\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425857-425886	30	NC_025146	Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111	98851-98880	7	0.767
CP025471_3	3.4\|425857\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425857-425886	30	MN270261	Streptococcus phage phi-SsuFJNP8_rum, complete genome	59052-59081	7	0.767
CP025471_3	3.5\|425923\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425923-425952	30	MN693782	Marine virus AFVG_250M789, complete genome	35899-35928	7	0.767
CP025471_3	3.5\|425923\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425923-425952	30	MN694722	Marine virus AFVG_250M790, complete genome	35869-35898	7	0.767
CP025471_3	3.7\|426055\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	426055-426084	30	NZ_CP014254	Listeria monocytogenes strain CFSAN023459 plasmid CFSAN023459_02, complete sequence	37080-37109	7	0.767
CP025471_3	3.1\|425659\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425659-425688	30	MT446392	UNVERIFIED: Escherichia virus TH15, complete genome	1045-1074	8	0.733
CP025471_3	3.5\|425923\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425923-425952	30	NC_024998	Acidovorax avenae subsp. avenae plasmid pAAA83 DNA, complete sequence, strain: 83	24521-24550	8	0.733
CP025471_3	3.5\|425923\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425923-425952	30	NC_015583	Novosphingobium sp. PP1Y plasmid Mpl, complete sequence	236824-236853	8	0.733
CP025471_3	3.1\|425659\|30\|CP025471\|PILER-CR,CRISPRCasFinder,CRT	425659-425688	30	NC_031020	Morganella phage vB_MmoM_MP1, complete genome	73883-73912	9	0.7

1. spacer 3.4|425857|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR735422 (Staphylococcus epidermidis strain none isolate Se_BPH0697 plasmid 2) position: , mismatch: 4, identity: 0.867

attttggtttctaggcttttcattttgact	CRISPR spacer
tttttggttgctaggcttttgattttgaat	Protospacer
 ******** ********** ******* *

2. spacer 3.1|425659|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to MT774386 (CrAssphage cr110_1, complete genome) position: , mismatch: 5, identity: 0.833

ttaattaagaaagttactgttgaagaaatt	CRISPR spacer
atgattcagaaacttactgttgaagaaatc	Protospacer
 *.*** ***** ****************.

3. spacer 3.5|425923|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to MN693469 (Marine virus AFVG_25M404, complete genome) position: , mismatch: 5, identity: 0.833

ccagcgacgctgatgtcttggcatgggaat	CRISPR spacer
cccgccgagctgaggtcttggcatgggaat	Protospacer
** ** . ***** ****************

4. spacer 3.1|425659|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NC_018486 (Bacillus thuringiensis HD-771 plasmid p01, complete sequence) position: , mismatch: 6, identity: 0.8

ttaattaagaaagttactgttgaagaaatt	CRISPR spacer
tatattaagaaagttagggttgaagaatta	Protospacer
*  *************  ********* *

5. spacer 3.1|425659|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to MH319723 (Marine virus AG-345-D19 Ga0172267_104 genomic sequence) position: , mismatch: 6, identity: 0.8

ttaattaagaaagttactgttgaagaaatt	CRISPR spacer
tacctaaagaaagttactgatgaagaagtt	Protospacer
*   * ************* *******.**

6. spacer 3.4|425857|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015439 (Anoxybacillus amylolyticus strain DSM 15939 plasmid pDSM15939_1, complete sequence) position: , mismatch: 6, identity: 0.8

attttggtttctaggcttttcattttgact	CRISPR spacer
tttttgctttctacgcttttcattttcctt	Protospacer
 ***** ****** ************  .*

7. spacer 3.10|426253|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LT222315 (Pseudomonas cerasi isolate Sour cherry (Prunus cerasus) symptomatic leaf plasmid p58T3) position: , mismatch: 6, identity: 0.8

-tactattcactgcatccctactgcaatact	CRISPR spacer
gcact-ttcactgcatccccactgcaaaccc	Protospacer
 .*** *************.*******  *.

8. spacer 3.10|426253|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LT222315 (Pseudomonas cerasi isolate Sour cherry (Prunus cerasus) symptomatic leaf plasmid p58T3) position: , mismatch: 6, identity: 0.8

-tactattcactgcatccctactgcaatact	CRISPR spacer
gcact-ttcactgcatccccactgcaaaccc	Protospacer
 .*** *************.*******  *.

9. spacer 3.10|426253|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LT963397 (Pseudomonas cerasi isolate PL963 plasmid PP2, complete sequence) position: , mismatch: 6, identity: 0.8

-tactattcactgcatccctactgcaatact	CRISPR spacer
gcact-ttcactgcatccccactgcaaaccc	Protospacer
 .*** *************.*******  *.

10. spacer 3.10|426253|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP026561 (Pseudomonas amygdali pv. morsprunorum strain R15244 plasmid p4_tig6, complete sequence) position: , mismatch: 6, identity: 0.8

-tactattcactgcatccctactgcaatact	CRISPR spacer
gcact-ttcactgcatccccactgcaaaccc	Protospacer
 .*** *************.*******  *.

11. spacer 3.10|426253|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NC_019292 (Pseudomonas savastanoi pv. savastanoi native plasmid pPsv48C complete sequence) position: , mismatch: 6, identity: 0.8

-tactattcactgcatccctactgcaatact	CRISPR spacer
gcact-ttcactgcatccccactgcaaaccc	Protospacer
 .*** *************.*******  *.

12. spacer 3.1|425659|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to MN694191 (Marine virus AFVG_250M444, complete genome) position: , mismatch: 7, identity: 0.767

ttaattaagaaagttactgttgaagaaatt	CRISPR spacer
caacaaaagaaagttactgttgatggaatt	Protospacer
. *   ***************** *.****

13. spacer 3.1|425659|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to MN694065 (Marine virus AFVG_250M443, complete genome) position: , mismatch: 7, identity: 0.767

ttaattaagaaagttactgttgaagaaatt	CRISPR spacer
caacaaaagaaagttactgttgatggaatt	Protospacer
. *   ***************** *.****

14. spacer 3.4|425857|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013684 (Clostridium botulinum strain AM282 plasmid pRSJ10_1, complete sequence) position: , mismatch: 7, identity: 0.767

attttggtttctaggcttttcattttgact	CRISPR spacer
tgtttgtttactaggcttttcattttcttt	Protospacer
  **** ** ****************  .*

15. spacer 3.4|425857|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NC_025146 (Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111) position: , mismatch: 7, identity: 0.767

attttggtttctaggcttttcattttgact	CRISPR spacer
tgtttgtttactaggcttttcattttcttt	Protospacer
  **** ** ****************  .*

16. spacer 3.4|425857|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to MN270261 (Streptococcus phage phi-SsuFJNP8_rum, complete genome) position: , mismatch: 7, identity: 0.767

attttggtttctaggcttttcattttgact	CRISPR spacer
gccttggtttcaaggcttttcattatccct	Protospacer
...******** ************ *  **

17. spacer 3.5|425923|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to MN693782 (Marine virus AFVG_250M789, complete genome) position: , mismatch: 7, identity: 0.767

ccagcgacgctgatgtcttggcatgggaat	CRISPR spacer
ttggctccgctgatgtcttgacatgggaag	Protospacer
...**  *************.********

18. spacer 3.5|425923|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to MN694722 (Marine virus AFVG_250M790, complete genome) position: , mismatch: 7, identity: 0.767

ccagcgacgctgatgtcttggcatgggaat	CRISPR spacer
ttggctccgctgatgtcttgacatgggaag	Protospacer
...**  *************.********

19. spacer 3.7|426055|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP014254 (Listeria monocytogenes strain CFSAN023459 plasmid CFSAN023459_02, complete sequence) position: , mismatch: 7, identity: 0.767

gtagggtaactgatgttagtagcgttattt	CRISPR spacer
agctgctaactaatgttagtagctttattt	Protospacer
.   * *****.*********** ******

20. spacer 3.1|425659|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to MT446392 (UNVERIFIED: Escherichia virus TH15, complete genome) position: , mismatch: 8, identity: 0.733

ttaattaagaaagttactgttgaagaaatt	CRISPR spacer
actgataacaaagttactgttgaagataat	Protospacer
 . . *** ***************** * *

21. spacer 3.5|425923|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NC_024998 (Acidovorax avenae subsp. avenae plasmid pAAA83 DNA, complete sequence, strain: 83) position: , mismatch: 8, identity: 0.733

ccagcgacgctgatgtcttggcatgggaat	CRISPR spacer
gcgacgacgctgatgtcttggaatggtgcg	Protospacer
 *..***************** **** .

22. spacer 3.5|425923|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NC_015583 (Novosphingobium sp. PP1Y plasmid Mpl, complete sequence) position: , mismatch: 8, identity: 0.733

ccagcgacgctgatgtcttggcatgggaat	CRISPR spacer
ggagcgacgctgatgtcatggcaacaggct	Protospacer
  *************** *****  .*. *

23. spacer 3.1|425659|30|CP025471|PILER-CR,CRISPRCasFinder,CRT matches to NC_031020 (Morganella phage vB_MmoM_MP1, complete genome) position: , mismatch: 9, identity: 0.7

ttaattaagaaagttactgttgaagaaatt	CRISPR spacer
ggaaataagaaaattactgttgaaggtgac	Protospacer
  ** *******.************. . .

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

509741 : 519225

Enterococcus_phage(33.33%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZP90245.1\|509741_511169_-	ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	5.0e-11	26.3
AZP90246.1\|511179_511755_-	ABC transporter permease	NA	NA	NA	NA
AZP90247.1\|512203_512944_+	3-oxoacyl-ACP reductase	Q06VL0	Trichoplusia_ni_ascovirus	3.1e-17	31.9
AZP90248.1\|513466_515617_+	anaerobic ribonucleoside-triphosphate reductase	A0A0C5KKX3	Enterococcus_phage	1.9e-256	59.9
AZP90249.1\|515627_516215_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A0C5K925	Enterococcus_phage	2.6e-51	53.8
AZP90250.1\|516229_517006_+	Fe-S cluster assembly ATPase SufC	A0A285PWH2	Cedratvirus	3.1e-07	24.6
AZP90251.1\|516986_518048_+	Fe-S cluster assembly protein SufD	NA	NA	NA	NA
AZP90252.1\|517995_519225_+	cysteine desulfurase CsdA	Q2XUY6	environmental_halophage	2.5e-83	41.2

DBSCAN-SWA_2

870302 : 915421

Lactobacillus_phage(25.0%)

terminase,capsid,tRNA,portal,integrase,tail

attL 859044:859058|attR 887741:887755

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
859044:859058	attL	NA	NA	NA	NA
AZP90565.1\|870302_871040_+\|tRNA	tRNA (guanosine(37)-N1)-methyltransferase TrmD	NA	NA	NA	NA
AZP90566.1\|871221_871887_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	2.7e-20	32.0
AZP90567.1\|871870_872626_+	iron export ABC transporter permease subunit FetB	NA	NA	NA	NA
AZP90568.1\|872741_873113_+	50S ribosomal protein L19	NA	NA	NA	NA
AZP90569.1\|873864_874191_-	hypothetical protein	M4STD1	Rhodobacter_phage	1.2e-05	34.3
AZP90570.1\|874212_874545_-	hypothetical protein	NA	NA	NA	NA
AZP90571.1\|874941_875391_+	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ	NA	NA	NA	NA
AZP90572.1\|875403_876363_+	ketoacyl-ACP synthase III	NA	NA	NA	NA
AZP90573.1\|876389_876626_+	acyl carrier protein	NA	NA	NA	NA
AZP90574.1\|876652_877597_+	ACP S-malonyltransferase	NA	NA	NA	NA
AZP90575.1\|877681_878410_+	3-oxoacyl-ACP reductase FabG	A0A167REC2	Powai_lake_megavirus	2.5e-06	27.5
AZP90576.1\|878425_879652_+	beta-ketoacyl-[acyl-carrier-protein] synthase II	NA	NA	NA	NA
AZP90577.1\|879656_880082_+	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit	NA	NA	NA	NA
AZP90578.1\|880094_880505_+	beta-hydroxyacyl-ACP dehydratase	NA	NA	NA	NA
AZP90579.1\|880521_881889_+	acetyl-CoA carboxylase biotin carboxylase subunit	NA	NA	NA	NA
AZP90580.1\|881878_882703_+	acetyl-CoA carboxylase subunit beta	NA	NA	NA	NA
AZP90581.1\|882719_883487_+	acetyl-CoA carboxylase carboxyltransferase subunit alpha	NA	NA	NA	NA
AZP90582.1\|883503_884262_+	enoyl-[acyl-carrier-protein] reductase FabI	NA	NA	NA	NA
AZP90583.1\|884389_885565_-\|integrase	integrase	A0A1P8BM23	Lactococcus_phage	2.3e-06	23.7
AZP90584.1\|885678_885867_-	hypothetical protein	NA	NA	NA	NA
AZP90585.1\|885954_886752_-	DUF1828 domain-containing protein	Q6SEA4	Lactobacillus_prophage	4.7e-67	50.0
AZP90586.1\|886768_887206_-	hypothetical protein	Q6SEA3	Lactobacillus_prophage	5.6e-30	44.7
AZP90587.1\|887291_888275_-	hypothetical protein	NA	NA	NA	NA
887741:887755	attR	NA	NA	NA	NA
AZP90588.1\|888343_888751_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
AZP90589.1\|888762_889134_-	XRE family transcriptional regulator	A8ATX5	Listeria_phage	6.0e-09	35.2
AZP90590.1\|889294_889537_+	XRE family transcriptional regulator	NA	NA	NA	NA
AZP90591.1\|889533_889863_+	hypothetical protein	NA	NA	NA	NA
AZP90592.1\|890079_890295_+	hypothetical protein	NA	NA	NA	NA
AZP90593.1\|890380_890845_+	hypothetical protein	NA	NA	NA	NA
AZP90594.1\|890845_891127_+	hypothetical protein	NA	NA	NA	NA
AZP90595.1\|891364_891610_+	hypothetical protein	NA	NA	NA	NA
AZP90596.1\|891602_892394_+	phage recombination protein Bet	A8ATK8	Listeria_phage	1.7e-61	53.4
AZP90597.1\|892413_893184_+	hypothetical protein	A0A0P0IZH9	Lactobacillus_phage	2.6e-54	43.1
AZP90598.1\|893193_894063_+	helix-turn-helix domain-containing protein	A0A0P0I7Q1	Lactobacillus_phage	3.1e-40	40.7
AZP90599.1\|894067_894757_+	hypothetical protein	E9LUU3	Lactobacillus_phage	3.2e-80	64.3
AZP90600.1\|894800_895028_+	hypothetical protein	NA	NA	NA	NA
AZP90601.1\|895042_895249_+	hypothetical protein	NA	NA	NA	NA
AZP90602.1\|895241_895667_+	single-stranded DNA-binding protein	A0A290GHL8	Caldibacillus_phage	4.7e-42	58.5
AZP90603.1\|895678_895984_+	helix-turn-helix domain-containing protein	NA	NA	NA	NA
AZP90604.1\|896097_896331_+	hypothetical protein	NA	NA	NA	NA
AZP90605.1\|896327_896738_+	hypothetical protein	NA	NA	NA	NA
AZP90606.1\|896942_897230_+	hypothetical protein	NA	NA	NA	NA
AZP90607.1\|897884_898742_+	hypothetical protein	NA	NA	NA	NA
AZP90608.1\|898725_899202_+	molecular chaperone Tir	NA	NA	NA	NA
AZP90609.1\|899275_899470_+	hypothetical protein	NA	NA	NA	NA
AZP90610.1\|899701_900409_+\|terminase	terminase	V5URT8	Oenococcus_phage	2.0e-13	39.3
AZP90611.1\|900405_901704_+\|terminase	PBSX family phage terminase large subunit	A0A1S5SA45	Streptococcus_phage	4.8e-138	55.8
AZP90612.1\|901715_903245_+\|portal	phage portal protein	A0A0B5D0F2	Listeria_phage	1.7e-97	39.6
AZP90613.1\|903241_904291_+	hypothetical protein	A0A1Z1LZL3	Bacillus_phage	1.6e-38	30.0
AZP90614.1\|904414_904993_+	hypothetical protein	O03931	Lactobacillus_phage	3.0e-15	34.3
AZP90615.1\|905006_905960_+\|capsid	phage major capsid protein	Q9T1B7	Listeria_phage	5.9e-101	62.6
AZP90616.1\|906021_906423_+	hypothetical protein	NA	NA	NA	NA
AZP90617.1\|906415_906793_+	hypothetical protein	NA	NA	NA	NA
AZP90618.1\|906789_907170_+	hypothetical protein	NA	NA	NA	NA
AZP90619.1\|907138_907579_+	hypothetical protein	NA	NA	NA	NA
AZP90620.1\|907594_908182_+	hypothetical protein	B3GW10	Streptococcus_phage	1.7e-10	35.6
AZP90621.1\|908255_908513_+	phosphoenolpyruvate synthase	NA	NA	NA	NA
AZP90622.1\|908582_909137_+	hypothetical protein	NA	NA	NA	NA
AZP90623.1\|909139_909760_+	hypothetical protein	NA	NA	NA	NA
AZP90624.1\|909763_915421_+\|tail	phage tail tape measure protein	D6PSZ3	Lactobacillus_phage	8.8e-43	57.1

DBSCAN-SWA_3

1074185 : 1082748

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZP90769.1\|1074185_1074767_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	1.5e-22	35.2
AZP90770.1\|1074766_1075813_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FC27	Synechococcus_phage	2.7e-54	37.7
AZP90771.1\|1075815_1077285_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	1.2e-57	34.3
AZP90772.1\|1077269_1079474_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	2.4e-145	41.4
AZP90773.1\|1079491_1080166_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
AZP90774.1\|1080162_1080423_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
AZP90775.1\|1080409_1081144_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SLB8	Cyanophage	4.1e-41	42.1
AZP90776.1\|1081121_1082282_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
AZP90777.1\|1082265_1082748_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.4e-18	39.7

DBSCAN-SWA_4

1112846 : 1120168

Staphylococcus_phage(28.57%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZP90805.1\|1112846_1113692_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	2.1e-17	35.6
AZP90806.1\|1113864_1114071_+	hypothetical protein	NA	NA	NA	NA
AZP90807.1\|1114087_1114570_-	dihydrofolate reductase	A0A076GDN3	Bacillus_phage	3.6e-22	39.1
AZP90808.1\|1114587_1115538_-	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	5.1e-113	59.9
AZP90809.1\|1115542_1117438_-	ABC transporter ATP-binding protein	A0A2K9L3Z8	Tupanvirus	2.5e-50	30.3
AZP90810.1\|1117440_1118649_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	3.8e-44	35.3
AZP90811.1\|1118764_1119634_+	YitT family protein	M1Q1P6	Streptococcus_phage	1.5e-55	37.8
AZP90812.1\|1119697_1120168_-	nucleoside 2-deoxyribosyltransferase	K4I206	Lactobacillus_phage	2.7e-14	34.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP025471

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection