CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
AP018449	Methylomusa anaerophila DNA, complete genome	10 crisprs	WYL,csa3,cas14j,cas3HD,RT,cas3,DinG,csx1,cmr1gr7,cas10,cmr3gr5,csm6,cmr4gr7,cmr5gr11,cmr6gr7,cas6,csm3gr7,cas2,cas1,cas4,cas5,cas7,cas8b1,csm5gr7,csm4gr5,csm2gr11	0	4	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: AP018449_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018449_1

913-2738

Orphan

Consensus_repeat	Method
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CRISPRCasFinder
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CRT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	PILER-CR

27 spacers

The CRISPR arrays of AP018449_1

>merge|AP018449|1|913-2738|CRISPRCasFinder,CRT,PILER-CR
TGTTCAATTCCTTATAGGTAAGCTACAAACAATGAATATGGTACAAGAAAAATTATATCATTGTTGGTTTCAATCCCTTATAGGTAAGCTACAAACGGAAGAAATGACAATTGATCAAGCGGCAGACATGTGTTTCAATCCCTTATAGGTAAGCTACAAACTCATAATTCATCGCGATGTGTGGGAGCAGCTAAGCCGTTTCAATCCCTTATAGGTAAGCTACAAACAACATGCCCGGTGTGGAAAAATATAGCGAAACAATTGTTTCAATCCCTTATAGGTAAGCTACAAACCATGAACTGAAGCATATCGGCGTTGGGCCGAAGGGGCGTTTCAATCCCTTATAGGTAAGCTACAAACTCCGGGCGATAGCCGAGATCCGCTGAACTAATAAAGTTTCAATCCCTTATAGGTAAGCTACAAACAAAAGAAAGCATTAGATTATCTCCAGAAATTCCCGCGTTTCAATCCCTTATAGGTAAGCTACAAACCAGCTTCAACTTCAACAACAAATGGAGGTTTTGTACGGGTTTCAATCCCTTATAGGTAAGCTACAAACCGCAGGCGTTGAATTAACTGTTGAAGCCCAGCCGAGGTTTCAATCCCTTATAGGTAAGCTACAAACTAAGAGTGCTCATATAAACTTCACTGCCCATTTGTTCGTTTCAATCCCTTATAGGTAAGCTACAAACATATCGGTTGATTCGGACAGCACTTAATGAAAAGAGGTTTCAATCCCTTATAGGTAAGCTACAAACAAAACCGGTTTGAATTTGATGCGTTTTACGATACACTGGTTTCAATCCCTTATAGGTAAGCTACAAACAGTCTATTGACGATGCCGTGAAAAAATTAATTAAATAGTTTCAATCCCTTATAGGTAAGCTACAAACCAATGCTATCGAACTTATACAGTTGCTTGCAGAGCCAAGTTTCAATCCCTTATAGGTAAGCTACAAACTAAACATAGCCGGCTCTTGTATTTTGTTCGCGATTGTTTCAATCCCTTATAGGTAAGCTACAAACAGCGTAGGCAACAGTGTTCGTCGGGAACGAGGTTGTATGTTTCAATCCCTTATAGGTAAGCTACAAACTTATGAAACATGGATGCAGTACCGGGATTTTTTATGTTTCAATCCCTTATAGGTAAGCTACAAACCCGTTTTGATTTTTTATGGCCCTCGACTGCAATTCCAAGTTTCAATCCCTTATAGGTAAGCTACAAACTAATGCTTTGCTTGCAAAATTGCGCCTGGCAGGGAGTTTCAATCCCTTATAGGTAAGCTACAAACGGGCATGAAAACCGAGTGGGATGACCCTGGAGAATGTTTGTTTCAATCCCTTATAGGTAAGCTACAAACTGCTAGTTAGCAAAAGCCTAGATCAAAGCATGTCGAGTTTCAATCCCTTATAGGTAAGCTACAAACACTACAGATGCTAGAAGACATGAGAGACAGTGTATTAGGTTTCAATCCCTTATAGGTAAGCTACAAACCGCCGCGCTCATGGCCGGCGATTATGACCAATCTGAAGGTTTCAATCCCTTATAGGTAAGCTACAAACTACCCGGTTCGCTTCAATGCCGATTTTACCGGTAGAGTTTCAATCCCTTATAGGTAAGCTACAAACTTCTCTTATGGAGAACAGTATACTCTGTTAGATTAGTTTCAATCCCTTATAGGTAAGCTACAAACACCTGGTACAGGCTATAGCCCGGGATTGTCTGGCTGGTTTCAATCCCTTATAGGTAAGCTACAAACTTTATTGGGAGGACTTTTCGGGCTTAACGCCAGTTCGTTTCAATCCCTTATAGGTAAGCTACAAAC

>AP018449|1|1|913-2738|CRISPRCasFinder
TGTTCAATTCCTTATAGGTAAGCTACAAAC	AATGAATATGGTACAAGAAAAATTATATCATTGTTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GGAAGAAATGACAATTGATCAAGCGGCAGACATGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TCATAATTCATCGCGATGTGTGGGAGCAGCTAAGCC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AACATGCCCGGTGTGGAAAAATATAGCGAAACAATT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATGAACTGAAGCATATCGGCGTTGGGCCGAAGGGGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TCCGGGCGATAGCCGAGATCCGCTGAACTAATAAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAAAGAAAGCATTAGATTATCTCCAGAAATTCCCGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAGCTTCAACTTCAACAACAAATGGAGGTTTTGTACGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGCAGGCGTTGAATTAACTGTTGAAGCCCAGCCGAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAAGAGTGCTCATATAAACTTCACTGCCCATTTGTTC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATATCGGTTGATTCGGACAGCACTTAATGAAAAGAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAAACCGGTTTGAATTTGATGCGTTTTACGATACACTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTCTATTGACGATGCCGTGAAAAAATTAATTAAATA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAATGCTATCGAACTTATACAGTTGCTTGCAGAGCCAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAAACATAGCCGGCTCTTGTATTTTGTTCGCGATT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGCGTAGGCAACAGTGTTCGTCGGGAACGAGGTTGTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTATGAAACATGGATGCAGTACCGGGATTTTTTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CCGTTTTGATTTTTTATGGCCCTCGACTGCAATTCCAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAATGCTTTGCTTGCAAAATTGCGCCTGGCAGGGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GGGCATGAAAACCGAGTGGGATGACCCTGGAGAATGTTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGCTAGTTAGCAAAAGCCTAGATCAAAGCATGTCGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ACTACAGATGCTAGAAGACATGAGAGACAGTGTATTAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGCCGCGCTCATGGCCGGCGATTATGACCAATCTGAAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TACCCGGTTCGCTTCAATGCCGATTTTACCGGTAGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTCTCTTATGGAGAACAGTATACTCTGTTAGATTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ACCTGGTACAGGCTATAGCCCGGGATTGTCTGGCTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTTATTGGGAGGACTTTTCGGGCTTAACGCCAGTTC
GTTTCAATCCCTTATAGGTAAGCTACAAAC

>AP018449|1|1|913-2738|CRT
TGTTCAATTCCTTATAGGTAAGCTACAAAC	AATGAATATGGTACAAGAAAAATTATATCATTGTTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GGAAGAAATGACAATTGATCAAGCGGCAGACATGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TCATAATTCATCGCGATGTGTGGGAGCAGCTAAGCC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AACATGCCCGGTGTGGAAAAATATAGCGAAACAATT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATGAACTGAAGCATATCGGCGTTGGGCCGAAGGGGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TCCGGGCGATAGCCGAGATCCGCTGAACTAATAAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAAAGAAAGCATTAGATTATCTCCAGAAATTCCCGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAGCTTCAACTTCAACAACAAATGGAGGTTTTGTACGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGCAGGCGTTGAATTAACTGTTGAAGCCCAGCCGAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAAGAGTGCTCATATAAACTTCACTGCCCATTTGTTC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATATCGGTTGATTCGGACAGCACTTAATGAAAAGAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAAACCGGTTTGAATTTGATGCGTTTTACGATACACTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTCTATTGACGATGCCGTGAAAAAATTAATTAAATA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAATGCTATCGAACTTATACAGTTGCTTGCAGAGCCAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAAACATAGCCGGCTCTTGTATTTTGTTCGCGATT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGCGTAGGCAACAGTGTTCGTCGGGAACGAGGTTGTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTATGAAACATGGATGCAGTACCGGGATTTTTTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CCGTTTTGATTTTTTATGGCCCTCGACTGCAATTCCAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAATGCTTTGCTTGCAAAATTGCGCCTGGCAGGGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GGGCATGAAAACCGAGTGGGATGACCCTGGAGAATGTTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGCTAGTTAGCAAAAGCCTAGATCAAAGCATGTCGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ACTACAGATGCTAGAAGACATGAGAGACAGTGTATTAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGCCGCGCTCATGGCCGGCGATTATGACCAATCTGAAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TACCCGGTTCGCTTCAATGCCGATTTTACCGGTAGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTCTCTTATGGAGAACAGTATACTCTGTTAGATTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ACCTGGTACAGGCTATAGCCCGGGATTGTCTGGCTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTTATTGGGAGGACTTTTCGGGCTTAACGCCAGTTC
GTTTCAATCCCTTATAGGTAAGCTACAAAC

>AP018449|1|1|915-2738|PILER-CR
TTCAATTCCTTATAGGTAAGCTACAAACAA	TGAATATGGTACAAGAAAAATTATATCATTGTTGGT
TTCAATCCCTTATAGGTAAGCTACAAACGG	AAGAAATGACAATTGATCAAGCGGCAGACATGTGT
TTCAATCCCTTATAGGTAAGCTACAAACTC	ATAATTCATCGCGATGTGTGGGAGCAGCTAAGCCGT
TTCAATCCCTTATAGGTAAGCTACAAACAA	CATGCCCGGTGTGGAAAAATATAGCGAAACAATTGT
TTCAATCCCTTATAGGTAAGCTACAAACCA	TGAACTGAAGCATATCGGCGTTGGGCCGAAGGGGCGT
TTCAATCCCTTATAGGTAAGCTACAAACTC	CGGGCGATAGCCGAGATCCGCTGAACTAATAAAGT
TTCAATCCCTTATAGGTAAGCTACAAACAA	AAGAAAGCATTAGATTATCTCCAGAAATTCCCGCGT
TTCAATCCCTTATAGGTAAGCTACAAACCA	GCTTCAACTTCAACAACAAATGGAGGTTTTGTACGGGT
TTCAATCCCTTATAGGTAAGCTACAAACCG	CAGGCGTTGAATTAACTGTTGAAGCCCAGCCGAGGT
TTCAATCCCTTATAGGTAAGCTACAAACTA	AGAGTGCTCATATAAACTTCACTGCCCATTTGTTCGT
TTCAATCCCTTATAGGTAAGCTACAAACAT	ATCGGTTGATTCGGACAGCACTTAATGAAAAGAGGT
TTCAATCCCTTATAGGTAAGCTACAAACAA	AACCGGTTTGAATTTGATGCGTTTTACGATACACTGGT
TTCAATCCCTTATAGGTAAGCTACAAACAG	TCTATTGACGATGCCGTGAAAAAATTAATTAAATAGT
TTCAATCCCTTATAGGTAAGCTACAAACCA	ATGCTATCGAACTTATACAGTTGCTTGCAGAGCCAAGT
TTCAATCCCTTATAGGTAAGCTACAAACTA	AACATAGCCGGCTCTTGTATTTTGTTCGCGATTGT
TTCAATCCCTTATAGGTAAGCTACAAACAG	CGTAGGCAACAGTGTTCGTCGGGAACGAGGTTGTATGT
TTCAATCCCTTATAGGTAAGCTACAAACTT	ATGAAACATGGATGCAGTACCGGGATTTTTTATGT
TTCAATCCCTTATAGGTAAGCTACAAACCC	GTTTTGATTTTTTATGGCCCTCGACTGCAATTCCAAGT
TTCAATCCCTTATAGGTAAGCTACAAACTA	ATGCTTTGCTTGCAAAATTGCGCCTGGCAGGGAGT
TTCAATCCCTTATAGGTAAGCTACAAACGG	GCATGAAAACCGAGTGGGATGACCCTGGAGAATGTTTGT
TTCAATCCCTTATAGGTAAGCTACAAACTG	CTAGTTAGCAAAAGCCTAGATCAAAGCATGTCGAGT
TTCAATCCCTTATAGGTAAGCTACAAACAC	TACAGATGCTAGAAGACATGAGAGACAGTGTATTAGGT
TTCAATCCCTTATAGGTAAGCTACAAACCG	CCGCGCTCATGGCCGGCGATTATGACCAATCTGAAGGT
TTCAATCCCTTATAGGTAAGCTACAAACTA	CCCGGTTCGCTTCAATGCCGATTTTACCGGTAGAGT
TTCAATCCCTTATAGGTAAGCTACAAACTT	CTCTTATGGAGAACAGTATACTCTGTTAGATTAGT
TTCAATCCCTTATAGGTAAGCTACAAACAC	CTGGTACAGGCTATAGCCCGGGATTGTCTGGCTGGT
TTCAATCCCTTATAGGTAAGCTACAAACTT	TATTGGGAGGACTTTTCGGGCTTAACGCCAGTTCGT
TTCAATCCCTTATAGGTAAGCTACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
AP018449.1\|BBB89377.1\|16273_17131_-\|glutathione-import-ATP-binding-protein-GsiA	unknown	unknown	gnl\|CDD\|213224
AP018449.1\|BBB89368.1\|3296_4043_-\|demethylmenaquinone-methyltransferase	unknown	unknown	gnl\|CDD\|379312
AP018449.1\|BBB89374.1\|13043_13847_-\|glycine/sarcosine-N-methyltransferase	unknown	unknown	gnl\|CDD\|379312
AP018449.1\|BBB89369.1\|4157_6386_-\|ferrichrome-receptor-FcuA-precursor	unknown	unknown	gnl\|CDD\|273805
AP018449.1\|BBB89371.1\|8199_10431_-\|ferrichrome-receptor-FcuA-precursor	unknown	unknown	gnl\|CDD\|273805
AP018449.1\|BBB89376.1\|14689_15940_-\|alanine-anticapsin-ligase-BacD	unknown	unknown	gnl\|CDD\|235010
AP018449.1\|BBB89370.1\|6484_8188_-\|nickel-binding-periplasmic-protein-precursor	unknown	unknown	gnl\|CDD\|173854
AP018449.1\|BBB89375.1\|13861_14680_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377194
AP018449.1\|BBB89373.1\|11820_13029_-\|multidrug-resistance-protein-MdtH	unknown	unknown	gnl\|CDD\|183255
AP018449.1\|BBB89372.1\|10498_11647_-\|putative-siderophore-biosynthesis-protein-SbnA	unknown	unknown	gnl\|CDD\|107204

Protein	Function_ID	Function_description	E-value
AP018449.1\|BBB89377.1\|16273_17131_-\|glutathione-import-ATP-binding-protein-GsiA	gnl\|CDD\|213224	cd03257, ABC_NikE_OppD_transporters, ATP-binding cassette domain of nickel/oligopeptides specific transporters. The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.	1.4299e-101
AP018449.1\|BBB89368.1\|3296_4043_-\|demethylmenaquinone-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	9.93698e-29
AP018449.1\|BBB89374.1\|13043_13847_-\|glycine/sarcosine-N-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	5.53954e-13
AP018449.1\|BBB89369.1\|4157_6386_-\|ferrichrome-receptor-FcuA-precursor	gnl\|CDD\|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	2.43012e-100
AP018449.1\|BBB89371.1\|8199_10431_-\|ferrichrome-receptor-FcuA-precursor	gnl\|CDD\|273805	TIGR01783, Ferrienterobactin_receptor, TonB-dependent siderophore receptor. This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins].	6.37695e-97
AP018449.1\|BBB89376.1\|14689_15940_-\|alanine-anticapsin-ligase-BacD	gnl\|CDD\|235010	PRK02186, PRK02186, argininosuccinate lyase; Provisional.	3.23337e-52
AP018449.1\|BBB89370.1\|6484_8188_-\|nickel-binding-periplasmic-protein-precursor	gnl\|CDD\|173854	cd08489, PBP2_NikA, The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel transport system, which functions in the import of nickel and in the control of chemotactic response away from nickel. The ATP-binding cassette (ABC) type nickel transport system is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, the initial nickel receptor. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
AP018449.1\|BBB89375.1\|13861_14680_-\|hypothetical-protein	gnl\|CDD\|377194	pfam04016, DUF364, Putative heavy-metal chelation. This domain of unknown function has a PLP-dependent transferase-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the C-terminus of proteins containing DUF4213, pfam13938. The structure of UnioProtKB:B8FUJ5, Structure 3l5o, suggests that the protein has an enolase N-terminal-like fold and this Rossmann-like C-terminal domain. Structural and bioinformatic analyses reveal partial similarities to Rossmann-like methyltransferases, with residues from the enolase-like fold combining to form a unique active site that is likely to be involved in the condensation or hydrolysis of molecules implicated in the synthesis of flavins, pterins or other siderophores. The protein may be playing a role in heavy-metal chelation.	7.55887e-08
AP018449.1\|BBB89373.1\|11820_13029_-\|multidrug-resistance-protein-MdtH	gnl\|CDD\|183255	PRK11646, PRK11646, multidrug efflux MFS transporter MdtH.	5.1027e-66
AP018449.1\|BBB89372.1\|10498_11647_-\|putative-siderophore-biosynthesis-protein-SbnA	gnl\|CDD\|107204	cd01561, CBS_like, CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.	9.31685e-131

>AP018449.1|BBB89368.1|3296_4043_-|demethylmenaquinone-methyltransferase
MLEKHIEIYWNSLAGIFNEYVQGEMACKKKQAWKMILRKYAGTAENTRILDVGTGPGFFAILLAEMDYSVTAIDKCDDMLTQARQNAASAGQAIHFLKADAHAAPFPAESFDLIVSRNVTWLLPNPLAVYQEWHRLLKPAGKVLVFDTNWFLRLSDPELKLQCDKYRQLAIKKGYKELITPEQQDESDDIARKLPLTYEKRPSWDEQAFCRSGFHNIIIQENINELIYDEIEQILYRPTPMFAICASK
>AP018449.1|BBB89369.1|4157_6386_-|ferrichrome-receptor-FcuA-precursor
MKRKISRAGKGLLYVLIGSSLCWPAPFIANAAEDAAKTAATTDQAADEAKVSETAPSDVQQYTLPPTEVTAKRDSQQSKDLPPAYAGGQVARGSRLGVLGNKDFLDTPFNITSYTDKLIENQQSHTLAGVLDNDPSVRFNSLSSYYDTWTIRGFTLSVGDIGFNGLYGILPTSSIGTEFVERVEVLKGPSALINGMQPSGSIGGSINLIPKRAGEEPLTRLNISYTGDSQLGGHIDIGRRFGENNRFGVRFNGAYRQGDTRFDGESQKVSLAVLGFDVRGHRFRASADLGYLESDFNAPTAEMYLASGLSVPRLPKSTFNFNPPWTYTNSKNTFGVIHGEFDLNPDWLVFASAGARKNTWDYVLGSATLTNAQGDFTESVTNYPLKYLAHTAELGIRGRFTSGLLRHQIVLSGTRLNIDRYQLSKPVTTFSSNLYNPVWGAQPGITDLGNLPLGSVTTLSGVALADTLSTADDRWQLTLGIRKQQVKVDRFDSTGAKTASYDKSATTPSVGLVIKARPNLSFYGNYIEGLQQGATAPAAAANAGEIFAPFKSKQYEAGLKWDAGTFATTLSAFQITQPSGLINPATLVYSVDGQQRNRGLELNVFGEPRKGTRLLGGVMLLDGKLVKTANGTYDGNTPVGVPRWTATLGAEWDTPFQPGLTLTARAVYNGSQYLDNGNTVQVAPWTRWDVGARYTFRQGGTPVTVRAMVTNVFNKRHWVGTTYGALTMGAPRTLLLSATMEL
>AP018449.1|BBB89370.1|6484_8188_-|nickel-binding-periplasmic-protein-precursor
MKINRLAEADKYVETAMGQEQKEEVSLIKFMKHNNWSKFLTIIFLIFLILLICGLLAGCGGKSTQTSTQSKILTYSYPKDIGPLNPHQYNPNQMVAQAMVYEPLVQYGADGKIIPWLAESWTISPDGKEYIFKLRKGVKFSDGTEFNAAAVKKNFDAVLANGKRHEWLEFIRQIQETRAVDDLTFTLVLKEVYYPTLQELALIRPLRFLAPSAFTDNGNTAETIKQPVGTGPWVLSEYKQGEMAVFVRNEHYWGPQPKLDKIIFKIISDGESRVMAFEKEELDLIYGYGSISIDAFKQLRDSGKYEAKLSEPLATRAIAVNSNRGPTKELKVRQALQHAVDKEALVKGVFFGIERKADTLFAPNFPYCDLGLKPYEFNLDKARTLLEEAGWKLPPGQEFREKDGQELELELCFESTDAVQKSVSEVLQGDMRKIGVRLKLVNEEKQAYEQRRKNGSFHLIFSNTWGVPYDPHSFVGSMRSPADADYQAQAGLPMKAEIDKTINDVLISTDELRRQDMYRYILGTLHDQAVYLPLTYLTNQAVYHKNVSGVIFLGSQYDIPFANMDKQ
>AP018449.1|BBB89371.1|8199_10431_-|ferrichrome-receptor-FcuA-precursor
MRKKMSRARKSLLYVLVGSGLFLYMPFIANAVEDAAETATTEDQAAEAKVSETASSDSDVKQYTLPTTEVTAKRDSRQSKDLPPAYAGGQVARGSRLGVLGNKDFLDTPFNITSYTDKLIENQQSHTLAGVVANDPSVRFNSGSSSYDTWTIRGFTLSCEDMGFNGLYGLLPNSFVGTELAERVEVLKGPSALVNGMQPAGSIGGSINLIPKRAGEEPLTSLTIGYTGDSQLGGHIDIGRRFGENNRFGVRFNGAYRQGDTGFDGESREVSLTALGLDVRGKRFRAAIDLGYQEVNQNAPTTSLILSNGLSVPALPKNTFNFSPPWTYANNKNTFGVIHGEFDLNPDWMIFASAGARKNTWDYILGSAVLTNAQGDFTASIDNFPLEYHVHTEELGIRGQFTSGSIRHQLVLSGTRFNMDRYYLSKTFYTFSSNLYRLAWGTQPDIPDLGTLPLGAATTLSSVVLADTLSTADGRLQLTVGARRQQIKVDNYSPAGTKTSTYSESATTPSVGLVIKARPNLSFYGNYIEGLQQGATAPATAANAGEIFAPFKSKQYEAGLKWDAGTFATTLSAFQITQPSGLINPATLVYSVDGQQRNRGLELNVFGEPRKGTRLLGGVMLLDGKLVKTANGTYDGNTPVGVPRWTATLGAEWDTPFQPGLTLTARAVYNGSQYLDNGNTVQVAPWTRWDVGARYTFRQGGTPVTVRAMVTNVFNKRHWVGTTYGALTMGAPRTLLLSATMEL
>AP018449.1|BBB89372.1|10498_11647_-|putative-siderophore-biosynthesis-protein-SbnA
MVNVITSILKTIGKTPLITIPNSNKTDEGQVLFKYERNNPGGSIKDRPAIYIIEEAEQRGLLKPGGTIIESSSGNFGISLAMIGAAKGYHVIILVDPKTTSTNVALLKCFGAEVIVVTEQDDCGSYHKTRISLANKLAREIKNAFRPDQCFNLLNSEAHYKSTAREIIEDCANKITTFIAAVSTGGQLGGISKYLKTFRPEVRIIGVDAVGSAVFGGNAHSYRIPGIGLGWTPDNLTMEYIDCAYKITDEQAFLTARALARNEGILMGPSGGACALVALKVAQNLTPENRVVCMISDGGERYIQTLFNDEWMKQQGFTTTVDIETLRAMARQLQPWSTCPATCANYRPDLNQSLEVPDTTLRMNAEVRNPGFYNQGIPIFID
>AP018449.1|BBB89373.1|11820_13029_-|multidrug-resistance-protein-MdtH
MAQSSGANHRGLMILLFFTFFMVMGFEMIMPLIIGYYVNTMGFSATAVAFALATRQFSQQGLAMVGGTLADRVDVRTLISIGVLLRSIGFVTLAFAKDFPLLLVSMILTGLGGVLFETPYQTAIATLTTERNRSRYYSLNNTITGIASTVGPLLGTLFLYLDFRAVCFGAAFCFMITFIISRFAMPPVVRVAPSYSVRSSLRAIGKDRPFLMLTLLMIIFWLAASQINLSFPLRIQELSGSADSVGMMFAVYAAVTTVLQYPLVSFMLRKYSPRQIVVIGIFIIAVALLLLSFINTTHMFLAVVVLFTLGFLLARPNQQTMAVAMANPQAMGMYLGVNSLGFALGSGFGAIIGGVFFDLATKTGLSMIPWFLFCAIAMVSMFGFILCKKLGQSPQLPEISTT
>AP018449.1|BBB89374.1|13043_13847_-|glycine/sarcosine-N-methyltransferase
MQIKLKTDTENFLHTNPALYLAFYRDPNLCTAHFIHALLAEYKAGKKVLDIGSGLGREVAYLNSMGYEATGLDNSQEMLSWAKEHYPASPFVYGDQADFSLNQQFDALFCVGSTFLYNFSNEAVLSSLQCFRKHLHNGGLLYLDMRNAAFFLTKEGQRWLTEDLAEQTIFEDTVVTLKTRFSIDLANQILQRDYSWTVTGWPPIIEHLRHRLFFPQELTNYLSSCSFRLLQIFDNPTPHAGKYDRQSPFVFSNEMLGTRMQVIAQAV
>AP018449.1|BBB89375.1|13861_14680_-|hypothetical-protein
MKKNQAHDSLSVNALREAILEGRLGSKPETLSVTGASYIYQTTQFPFSETKYHNYYLLIRVESYFGACSHTPDQLDMRIASQLSGLPLAAALRDKRLPAQIAAMDAYLGVINPHQDFCTKVVDIPGGTPVQKAKLRDALIADMADIKVSQKVALIGVVNPLVEAITQRGGTCLPCDLQLKVTQWGEAVERDMEKVLEKADSVICTAMTLSNGTFDRILARVREKQIPLTVYAQTGSAAIAQFMEKGVTALVAEPFPFSQFSAAASQLYCYTI
>AP018449.1|BBB89376.1|14689_15940_-|alanine-anticapsin-ligase-BacD
MAHILMVESWVGASGNLLPPLLKSLGHTYTFVTRKPEHYKSALNTEKHAVFQYADSVLVTETNDLSGLIEFLKPYQFDGIITVCDYYIEIVKEIAKTFNLPCPFPDKVKTVRQKHLLRQALDRAGLANPQYRLAHSWAEVEKAANEIGYPLVIKPVDLASSAFVRFIRNVEELQDAYHALEAFPYNFRDQERDCTYLLEEYMRGEEVSIESVSYNGETTILGITDKSITGSPYFIESGHMFPAPLNDKTRSMVTEFVWDVLKAVGFDHGIAHTEVKITAEGPRVVEINPRTAGNYIVELIERVTGINLLHAFIDLSLGIKPAISAKDSGITSAAIMFLVPPQGGRITEIQGGESLATDEHIARYKIENCVGKNIDSPIDNACYLGHIIAQDAEGLNARFYAEEALKRIVFNFNDKG
>AP018449.1|BBB89377.1|16273_17131_-|glutathione-import-ATP-binding-protein-GsiA
MPAAQPLLELRGVSKHFHGGGIFKQGRKVQAAKAVSLTLGAGECLGLVGESGSGKSTLGRIILGIERPETGEVLFQGVNLYGKDKAAVRAVRRDLQVVFQDCFSSVNPRLTAGESIAEPLKNFARLSQREERRTVGELLELVGLKAGDAAKYPHQFSGGQLQRVCIARAISLRPKLIVLDEAVSSLDVLVQTQILALLSDLREELTMSYVFISHDLAAVARLSDRLAVMSAGEIVERLEDMADIQCLTHPVSLALLAAVLPAQPVSCFEQHSTVDNFAAAASPVQ

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Crispr_ID: AP018449_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018449_2

23969-25403

Orphan

Consensus_repeat	Method
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CRT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	PILER-CR
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CRISPRCasFinder

21 spacers

The CRISPR arrays of AP018449_2

>merge|AP018449|2|23969-25403|CRT,PILER-CR,CRISPRCasFinder
CTATAAGTCCAGCATAGGTAAGCTAGAAAGCAGAGTCACGAAAGAAAACCTTGTCCAACTGATGCGTTTCAATTCCTTATAGGTAAGCTACAAACCGAAGACCAATCTGCCGATATTTATATCGAAATTCCTACGTTTCAATTCCTTATAGGTAAGCTACAAACTGCCGTGCAGAGCGTGATAAGTGGCTTGCTAACTTAGTTTCAATTCCTTATAGGTAAGCTACAAACTGCTGCATTTTTTTGTCCATTATGACTTCTTTATTTTGTTTCAATTCCTTATAGGTAAGCTACAAACTATATATAGTGTACCGATGTACCGAGTGTACCGAGGTTTCAATTCCTTATAGGTAAGCTACAAACTGGTTCTTGAGAAGTTGATTCGACTTTTACGGTAGGCTGTTTCAATTCCTTATAGGTAAGCTACAAACGCGCTCTCCGGGAACAAAGTACTTGTCCCGGTAGGCGGGTTTCAATTCCTTATAGGTAAGCTACAAACCGTAGAGAAGCTTCGACAAGAAAATGCCTCTTTAAAAAGTTTCAATTCCTTATAGGTAAGCTACAAACACCCGCATAAACACTAGAATATTAGCGGTTCAAGTGTTTCAATTCCTTATAGGTAAGCTACAAACGGTACGACATTCCCATTCATAGGCGATATCATCTAGTTTCAATTCCTTATAGGTAAGCTACAAACTGCCCATCGGAAGAAGCCCTTGAAATAGAAGAAGAGTGTTTCAATTCCTTATAGGTAAGCTACAAACTACCAGTTCCCCCGCCTAAGATGCAGTTGAAGATCAAGTTTCAATTCCTTATAGGTAAGCTACAAACCCTTATCCTTTGCAGTATTGGCGGTCTGCAACTCGGGTTTCAATTCCTTATAGGTAAGCTACAAACAGCGGGCCAAATATGGGCAGAAGTTATGGAGTGGTTGTTTCAATTCCTTATAGGTAAGCTACAAACACGAAGTAGCTCCACTATACGAAGATACCGACGAATAGTTTCAATTCCTTATAGGTAAGCTACAAACATCCATTGCCTTGCAACATCCGAACCATGTTCTTGGATGTTTCAATTCCTTATAGGTAAGCTACAAACCCGGGCACTTCTCCGTAAACTTCCGGAACAAGTCAGGAGTTTCAATTCCTTATAGGTAAGCTACAAACAATTTGTCGAACTATATAAAAATAGGTCGAAAATCAGTTTCAATTCCTTATAGGTAAGCTACAAACTACGCCAATGTAGCGTATTACGCCCTCCACAAGCTCCAGTTTCAATTCCTTATAGGTAAGCTACAAACAGGGGATATTTTGCTGGATAAAATACAAATATTTTTTGTTTCAATTCCTTATAGGTAAGCTACAAACGATTGGTCACCGCTAAGAGAACCTCCCGAAAATAGAAGGGTTTCAATTCCTTATAGGTAAGCTACAAAC

>AP018449|2|2|23969-25403|CRT
CTATAAGTCCAGCATAGGTAAGCTAGAAAG	CAGAGTCACGAAAGAAAACCTTGTCCAACTGATGC
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CGAAGACCAATCTGCCGATATTTATATCGAAATTCCTAC
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGCCGTGCAGAGCGTGATAAGTGGCTTGCTAACTTA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGCTGCATTTTTTTGTCCATTATGACTTCTTTATTTT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TATATATAGTGTACCGATGTACCGAGTGTACCGAG
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGGTTCTTGAGAAGTTGATTCGACTTTTACGGTAGGCT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	GCGCTCTCCGGGAACAAAGTACTTGTCCCGGTAGGCGG
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CGTAGAGAAGCTTCGACAAGAAAATGCCTCTTTAAAAA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	ACCCGCATAAACACTAGAATATTAGCGGTTCAAGT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	GGTACGACATTCCCATTCATAGGCGATATCATCTA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGCCCATCGGAAGAAGCCCTTGAAATAGAAGAAGAGT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TACCAGTTCCCCCGCCTAAGATGCAGTTGAAGATCAA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CCTTATCCTTTGCAGTATTGGCGGTCTGCAACTCGG
GTTTCAATTCCTTATAGGTAAGCTACAAAC	AGCGGGCCAAATATGGGCAGAAGTTATGGAGTGGTT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	ACGAAGTAGCTCCACTATACGAAGATACCGACGAATA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	ATCCATTGCCTTGCAACATCCGAACCATGTTCTTGGAT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CCGGGCACTTCTCCGTAAACTTCCGGAACAAGTCAGGA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	AATTTGTCGAACTATATAAAAATAGGTCGAAAATCA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TACGCCAATGTAGCGTATTACGCCCTCCACAAGCTCCA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	AGGGGATATTTTGCTGGATAAAATACAAATATTTTTT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	GATTGGTCACCGCTAAGAGAACCTCCCGAAAATAGAAGG
GTTTCAATTCCTTATAGGTAAGCTACAAAC

>AP018449|2|2|24034-25403|PILER-CR
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CGAAGACCAATCTGCCGATATTTATATCGAAATTCCTAC
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGCCGTGCAGAGCGTGATAAGTGGCTTGCTAACTTA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGCTGCATTTTTTTGTCCATTATGACTTCTTTATTTT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TATATATAGTGTACCGATGTACCGAGTGTACCGAG
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGGTTCTTGAGAAGTTGATTCGACTTTTACGGTAGGCT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	GCGCTCTCCGGGAACAAAGTACTTGTCCCGGTAGGCGG
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CGTAGAGAAGCTTCGACAAGAAAATGCCTCTTTAAAAA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	ACCCGCATAAACACTAGAATATTAGCGGTTCAAGT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	GGTACGACATTCCCATTCATAGGCGATATCATCTA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGCCCATCGGAAGAAGCCCTTGAAATAGAAGAAGAGT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TACCAGTTCCCCCGCCTAAGATGCAGTTGAAGATCAA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CCTTATCCTTTGCAGTATTGGCGGTCTGCAACTCGG
GTTTCAATTCCTTATAGGTAAGCTACAAAC	AGCGGGCCAAATATGGGCAGAAGTTATGGAGTGGTT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	ACGAAGTAGCTCCACTATACGAAGATACCGACGAATA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	ATCCATTGCCTTGCAACATCCGAACCATGTTCTTGGAT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CCGGGCACTTCTCCGTAAACTTCCGGAACAAGTCAGGA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	AATTTGTCGAACTATATAAAAATAGGTCGAAAATCA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TACGCCAATGTAGCGTATTACGCCCTCCACAAGCTCCA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	AGGGGATATTTTGCTGGATAAAATACAAATATTTTTT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	GATTGGTCACCGCTAAGAGAACCTCCCGAAAATAGAAGG
GTTTCAATTCCTTATAGGTAAGCTACAAAC

>AP018449|2|2|24034-25403|CRISPRCasFinder
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CGAAGACCAATCTGCCGATATTTATATCGAAATTCCTAC
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGCCGTGCAGAGCGTGATAAGTGGCTTGCTAACTTA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGCTGCATTTTTTTGTCCATTATGACTTCTTTATTTT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TATATATAGTGTACCGATGTACCGAGTGTACCGAG
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGGTTCTTGAGAAGTTGATTCGACTTTTACGGTAGGCT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	GCGCTCTCCGGGAACAAAGTACTTGTCCCGGTAGGCGG
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CGTAGAGAAGCTTCGACAAGAAAATGCCTCTTTAAAAA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	ACCCGCATAAACACTAGAATATTAGCGGTTCAAGT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	GGTACGACATTCCCATTCATAGGCGATATCATCTA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TGCCCATCGGAAGAAGCCCTTGAAATAGAAGAAGAGT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TACCAGTTCCCCCGCCTAAGATGCAGTTGAAGATCAA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CCTTATCCTTTGCAGTATTGGCGGTCTGCAACTCGG
GTTTCAATTCCTTATAGGTAAGCTACAAAC	AGCGGGCCAAATATGGGCAGAAGTTATGGAGTGGTT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	ACGAAGTAGCTCCACTATACGAAGATACCGACGAATA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	ATCCATTGCCTTGCAACATCCGAACCATGTTCTTGGAT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	CCGGGCACTTCTCCGTAAACTTCCGGAACAAGTCAGGA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	AATTTGTCGAACTATATAAAAATAGGTCGAAAATCA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	TACGCCAATGTAGCGTATTACGCCCTCCACAAGCTCCA
GTTTCAATTCCTTATAGGTAAGCTACAAAC	AGGGGATATTTTGCTGGATAAAATACAAATATTTTTT
GTTTCAATTCCTTATAGGTAAGCTACAAAC	GATTGGTCACCGCTAAGAGAACCTCCCGAAAATAGAAGG
GTTTCAATTCCTTATAGGTAAGCTACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
AP018449.1\|BBB89382.1\|21794_22172_+\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB89377.1\|16273_17131_-\|glutathione-import-ATP-binding-protein-GsiA	unknown	unknown	gnl\|CDD\|213224
AP018449.1\|BBB89385.1\|26065_26317_-\|putative-regulator-PrlF	unknown	unknown	gnl\|CDD\|198034
AP018449.1\|BBB89383.1\|22789_23167_-\|HicB-family-protein	unknown	unknown	gnl\|CDD\|374224
AP018449.1\|BBB89376.1\|14689_15940_-\|alanine-anticapsin-ligase-BacD	unknown	unknown	gnl\|CDD\|235010
AP018449.1\|BBB89392.1\|29441_30206_-\|corrinoid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|223687
AP018449.1\|BBB89388.1\|27749_28442_-\|redox-sensing-transcriptional-repressor-Rex	unknown	unknown	gnl\|CDD\|235486
AP018449.1\|BBB89387.1\|27116_27725_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379312
AP018449.1\|BBB89379.1\|17966_18812_-\|nickel-transport-system-permease-protein-NikC	unknown	unknown	gnl\|CDD\|131837
AP018449.1\|BBB89389.1\|28451_28619_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB89394.1\|31073_32180_-\|hemin-transport-system-permease-protein-HmuU	unknown	unknown	gnl\|CDD\|376439
AP018449.1\|BBB89380.1\|18808_19750_-\|nickel-transport-system-permease-protein-NikB	unknown	unknown	gnl\|CDD\|182400
AP018449.1\|BBB89393.1\|30250_31033_-\|putative-siderophore-transport-system-ATP-binding-protein-YusV	unknown	unknown	gnl\|CDD\|224045
AP018449.1\|BBB89381.1\|19774_21394_-\|nickel-binding-periplasmic-protein-precursor	unknown	unknown	gnl\|CDD\|173854
AP018449.1\|BBB89384.1\|23210_23444_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB89375.1\|13861_14680_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377194
AP018449.1\|BBB89391.1\|29152_29470_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|238559
AP018449.1\|BBB89378.1\|17105_17948_-\|oligopeptide-transport-ATP-binding-protein-OppD	unknown	unknown	gnl\|CDD\|223521
AP018449.1\|BBB89386.1\|26501_27113_+\|FmdE,-Molybdenum-formylmethanofuran-dehydrogenase-operon	unknown	unknown	gnl\|CDD\|225102
AP018449.1\|BBB89390.1\|28718_29054_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236641

Protein	Function_ID	Function_description	E-value
AP018449.1\|BBB89377.1\|16273_17131_-\|glutathione-import-ATP-binding-protein-GsiA	gnl\|CDD\|213224	cd03257, ABC_NikE_OppD_transporters, ATP-binding cassette domain of nickel/oligopeptides specific transporters. The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.	1.4299e-101
AP018449.1\|BBB89385.1\|26065_26317_-\|putative-regulator-PrlF	gnl\|CDD\|198034	smart00966, SpoVT_AbrB, SpoVT / AbrB like domain. This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins.	1.12176e-08
AP018449.1\|BBB89379.1\|17966_18812_-\|nickel-transport-system-permease-protein-NikC	gnl\|CDD\|131837	TIGR02790, Nickel_transport_system_permease_protein_nikC., nickel ABC transporter, permease subunit NikC. This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds].	3.39022e-122
AP018449.1\|BBB89376.1\|14689_15940_-\|alanine-anticapsin-ligase-BacD	gnl\|CDD\|235010	PRK02186, PRK02186, argininosuccinate lyase; Provisional.	3.23337e-52
AP018449.1\|BBB89392.1\|29441_30206_-\|corrinoid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|223687	COG0614, FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism].	4.04051e-36
AP018449.1\|BBB89388.1\|27749_28442_-\|redox-sensing-transcriptional-repressor-Rex	gnl\|CDD\|235486	PRK05472, PRK05472, redox-sensing transcriptional repressor Rex; Provisional.	1.70899e-63
AP018449.1\|BBB89387.1\|27116_27725_-\|hypothetical-protein	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	6.83421e-18
AP018449.1\|BBB89383.1\|22789_23167_-\|HicB-family-protein	gnl\|CDD\|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	6.70862e-12
AP018449.1\|BBB89394.1\|31073_32180_-\|hemin-transport-system-permease-protein-HmuU	gnl\|CDD\|376439	pfam01032, FecCD, FecCD transport family. This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	4.29674e-87
AP018449.1\|BBB89380.1\|18808_19750_-\|nickel-transport-system-permease-protein-NikB	gnl\|CDD\|182400	PRK10352, PRK10352, nickel transporter permease NikB; Provisional.	9.8011e-145
AP018449.1\|BBB89393.1\|30250_31033_-\|putative-siderophore-transport-system-ATP-binding-protein-YusV	gnl\|CDD\|224045	COG1120, FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism].	3.27136e-120
AP018449.1\|BBB89381.1\|19774_21394_-\|nickel-binding-periplasmic-protein-precursor	gnl\|CDD\|173854	cd08489, PBP2_NikA, The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding domain of nickel transport system, which functions in the import of nickel and in the control of chemotactic response away from nickel. The ATP-binding cassette (ABC) type nickel transport system is comprised of five subunits NikABCDE: the two pore-forming integral inner membrane proteins NikB and NikC; the two inner membrane-associated proteins with ATPase activity NikD and NikE; and the periplasmic nickel binding NikA, the initial nickel receptor. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
AP018449.1\|BBB89390.1\|28718_29054_-\|hypothetical-protein	gnl\|CDD\|236641	PRK10019, PRK10019, nickel/cobalt efflux transporter RcnA.	0.00439478
AP018449.1\|BBB89375.1\|13861_14680_-\|hypothetical-protein	gnl\|CDD\|377194	pfam04016, DUF364, Putative heavy-metal chelation. This domain of unknown function has a PLP-dependent transferase-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the C-terminus of proteins containing DUF4213, pfam13938. The structure of UnioProtKB:B8FUJ5, Structure 3l5o, suggests that the protein has an enolase N-terminal-like fold and this Rossmann-like C-terminal domain. Structural and bioinformatic analyses reveal partial similarities to Rossmann-like methyltransferases, with residues from the enolase-like fold combining to form a unique active site that is likely to be involved in the condensation or hydrolysis of molecules implicated in the synthesis of flavins, pterins or other siderophores. The protein may be playing a role in heavy-metal chelation.	7.55887e-08
AP018449.1\|BBB89391.1\|29152_29470_-\|hypothetical-protein	gnl\|CDD\|238559	cd01139, TroA_f, Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind their ligands in the cleft between these domains.	1.86808e-13
AP018449.1\|BBB89378.1\|17105_17948_-\|oligopeptide-transport-ATP-binding-protein-OppD	gnl\|CDD\|223521	COG0444, DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	4.95397e-121
AP018449.1\|BBB89386.1\|26501_27113_+\|FmdE,-Molybdenum-formylmethanofuran-dehydrogenase-operon	gnl\|CDD\|225102	COG2191, COG2191, Formylmethanofuran dehydrogenase subunit E [Energy production and conversion].	9.45381e-67

>AP018449.1|BBB89384.1|23210_23444_-|hypothetical-protein
MTQKEKLAAKIKNNPRNVSFDDLHKFLEMNGATWWEGGRKSHRVYNLNGQSLSIPRDKPVKAVYVKMAIELVEGKGE
>AP018449.1|BBB89383.1|22789_23167_-|HicB-family-protein
MKSLNDYLELAYPFSVRPLSEEDGGGWIVEFPDLKGCIGTGDSIEEALKDAMAAKEAWIEATLSFGREVPEPNAAAEFNGKLLLRTTKSIHRWIVEEADAEGTSANQFINYILSMEKGRRNQKRI
>AP018449.1|BBB89382.1|21794_22172_+|hypothetical-protein
MSEADKQLAVNLTIAIIAANPRTTYIKTAGGVETLVPSLSIENIGGLVKHYYTLLKSLDNDSDADKELAVNLTIAVIAANPRTTYIKTAGGVEVLVPSLSIESIDGLVKCYYTLLKSLDSDSDQQ
>AP018449.1|BBB89381.1|19774_21394_-|nickel-binding-periplasmic-protein-precursor
MTVKVKQFHRFKKYAALLIALVLLVTLAAGCGSQSSQSPAKEKVLNFSWAKDIGPLNPHMYNPNQMFAQALVYEPLVQYSADGKIIPWLAESWTISPDGKEYIFKLRPDVKFSDGTPFNAAAVKKNFDAVLANGKRHDWLAFIRQIKETQVIDDNTFKLVLKEAYYPVLQELALIRPIRFLAPAQFPDNGNTGEGIKKPIGTGPWVLSEYKQGEVAVFVRNEHYWGAKPKVDKLVVKIIPDSESRVVAFEKKELDLIYGSGSISMDAFKQLQQSGKYETQLSEPLATRVLAVNSNKGATRALKVRQALQHAVNKDAFVKGVLFGTERKADTLLAANFPYCNLGLKPYEYSEAQAKALLEEAGWQEVPGKEFREKDGEVLELEVCFVSTDAIQKSVAEVLQGDLRKIGIKVKLTGEEEGAISERQKNGNFNLIYSDTWGAPYDPHSLVGSMREPAHADYQAQAGLPMKAEIDRLASDVLVSTDEGKRQEMYKQIFTTLHEQAVYLPLSYLTNIVVYPKNVTGVTFMGSQYEIPFVTMDIQ
>AP018449.1|BBB89380.1|18808_19750_-|nickel-transport-system-permease-protein-NikB
MLGYIVKRLLSLIPVLVGISLITFLILRLTPGDPAEAYLRLSQIPPTQSAVAAVRAELGLDRPLPVQYWDWLIKALTLDFGRSYATHRPVWDEMMFLLPATAQLAAVSLVITLVLSIPMGIFSALHKDGWFDNFCRLLAFTSAAMPNFWLGFMLMYFFALKLDLLPTLGRGSWAHFILPALTLSFSYIATYIRLLRTSMLENLDQPFVLYARARGLRERWIIGRHVLKNAMLPVVTALGMSIGHLLSGSVIVESVFSWPGVGRFCVSAILSRDYPVVQCFVLIMAVVFVIANLLVDIAYAWLDPRIRLKGESA
>AP018449.1|BBB89379.1|17966_18812_-|nickel-transport-system-permease-protein-NikC
MRVMAATFMQNLTGRRTLVAVGLLVILVNILLAVLAPVLAPHDPNDVSLERKLMPPDGSYLLGTDHLGRCILSRLIHGARVSLGAALAVMSATLAISTVVGAAAGFAGGRVDAVIMRLCDIFLAFPSLILALALVGVMGPGLTNVVLAMALSQWAWYARMIRGMVLSLKERNYVLAAKVAGTGQAVIIARHILPNILPQIAVLATLDVGWVILHIAGMSFLGLGIQPPTPEWGAMINDGRQFLRGYPSLMAYPGFMILSVVMAFNLLGDALRDMVDPKGKC
>AP018449.1|BBB89378.1|17105_17948_-|oligopeptide-transport-ATP-binding-protein-OppD
MKKQPLLAVEGLEIVIRRKEQVVPVVRNLSFQIDKGAVFGLVGESGCGKTMTCLAVLNLLPAGIMQTGGQIQINGKSLGSLSSAEWRQLRGDRIALIMQNPMSAFDAICTIGDHFIETLLAHGKTDTKVARATAIEYLTRVGLPDAGLLLRQYPFELSGGMLQRVIIAIALAQKPDLIIADEPTTALDATSQVQILDLLAGVRRDFGTSILLISHDLAVIARLADEVAVMCDGQIVEQAPAGELFTAPQHAYTKLLLKARSGLNLRCERRVVHAGSATAS
>AP018449.1|BBB89377.1|16273_17131_-|glutathione-import-ATP-binding-protein-GsiA
MPAAQPLLELRGVSKHFHGGGIFKQGRKVQAAKAVSLTLGAGECLGLVGESGSGKSTLGRIILGIERPETGEVLFQGVNLYGKDKAAVRAVRRDLQVVFQDCFSSVNPRLTAGESIAEPLKNFARLSQREERRTVGELLELVGLKAGDAAKYPHQFSGGQLQRVCIARAISLRPKLIVLDEAVSSLDVLVQTQILALLSDLREELTMSYVFISHDLAAVARLSDRLAVMSAGEIVERLEDMADIQCLTHPVSLALLAAVLPAQPVSCFEQHSTVDNFAAAASPVQ
>AP018449.1|BBB89376.1|14689_15940_-|alanine-anticapsin-ligase-BacD
MAHILMVESWVGASGNLLPPLLKSLGHTYTFVTRKPEHYKSALNTEKHAVFQYADSVLVTETNDLSGLIEFLKPYQFDGIITVCDYYIEIVKEIAKTFNLPCPFPDKVKTVRQKHLLRQALDRAGLANPQYRLAHSWAEVEKAANEIGYPLVIKPVDLASSAFVRFIRNVEELQDAYHALEAFPYNFRDQERDCTYLLEEYMRGEEVSIESVSYNGETTILGITDKSITGSPYFIESGHMFPAPLNDKTRSMVTEFVWDVLKAVGFDHGIAHTEVKITAEGPRVVEINPRTAGNYIVELIERVTGINLLHAFIDLSLGIKPAISAKDSGITSAAIMFLVPPQGGRITEIQGGESLATDEHIARYKIENCVGKNIDSPIDNACYLGHIIAQDAEGLNARFYAEEALKRIVFNFNDKG
>AP018449.1|BBB89375.1|13861_14680_-|hypothetical-protein
MKKNQAHDSLSVNALREAILEGRLGSKPETLSVTGASYIYQTTQFPFSETKYHNYYLLIRVESYFGACSHTPDQLDMRIASQLSGLPLAAALRDKRLPAQIAAMDAYLGVINPHQDFCTKVVDIPGGTPVQKAKLRDALIADMADIKVSQKVALIGVVNPLVEAITQRGGTCLPCDLQLKVTQWGEAVERDMEKVLEKADSVICTAMTLSNGTFDRILARVREKQIPLTVYAQTGSAAIAQFMEKGVTALVAEPFPFSQFSAAASQLYCYTI
>AP018449.1|BBB89385.1|26065_26317_-|putative-regulator-PrlF
MAAAKGQVTIPKTIRELLNLNEGDRVAFIEDDGKVMITKANLIALRELQDALSKEAQEKGITEEKFLNELEVVQEEMWSERKK
>AP018449.1|BBB89386.1|26501_27113_+|FmdE,-Molybdenum-formylmethanofuran-dehydrogenase-operon
MYSNYPADYQKAIEFHGHCCPGLAIGYLASKLALEHLKVERAVDEELVAIVECDACGIDAVQSLLGCTIGKGNLIFKDHGKQAYTIGNRQTGQAVRVVMTGEIAPLSREQEEIRNAVFGGSATPEQETAWRELQQQRVESMLTTPPEKLFKVREVDLELPSEAKIFGSVICEYCGEKIMEARARLKNGKIACLACTEEYTRGW
>AP018449.1|BBB89387.1|27116_27725_-|hypothetical-protein
MEKNSTYFDRLAEQWDTTRMQDNGKITQLVKLIGLCPGNRVLDAGCGTGVLLPFVKKEIGSDGHITALDYSKNMIARAVSKYGDLGGINFLVCDIMDFVKDVGDAFYDAVICFNFFPHIQNKPRFFCCVWEMLKAEGSLIIMHDISRQTVNGIHQGSKAVENDLLPPGETVKDWLLKADYAVQLVIDSDDRYFVKAVKGDKR
>AP018449.1|BBB89388.1|27749_28442_-|redox-sensing-transcriptional-repressor-Rex
MKARSGISKLTINRMVIYYNTLKNMLEEGVEIFISTELGRRTGIGPSLIRRDLCNFGDFGTRGMGYRVESLMEWIGAILGYDAIWNIAVVGEGLPSLVLSHYYNFLPPGFQIKAAFDLDDRYHNLVLPDLGLAIEGLEKLNTTIRKKKITIGLVVTGPQDAQPVTNRLIEAGISGIANFSPVPVMVPDNIALTQINLSTYLSQLSYDLSDLSPEGSPQRMDGNERRYALG
>AP018449.1|BBB89389.1|28451_28619_-|hypothetical-protein
MRNMKSAGTEVAFLLLKMIICHQRYETVMGMETLVHTFLIFNIDSKRKRKREKGG
>AP018449.1|BBB89390.1|28718_29054_-|hypothetical-protein
MSCQNQNIPHDHSHGYIPEGHDHTHSDASQVPHGHTHEFEHLEPAGVNMQDHAHNSENVHNHIHAHVHTHAHSHPGIGEHAHPHVHYHSHPHAHDHGYDGNMKEDGHSHTH
>AP018449.1|BBB89391.1|29152_29470_-|hypothetical-protein
MVVKTISSNSKAMGEGFTDKTAVQAVYDGIISRTGWNELAAVKNNKVLLLAQNIGTTPEGSIIGMLYMAKTMYPDKFADIDPYEVYKQMEKEFFNIDPKGIIVFP
>AP018449.1|BBB89392.1|29441_30206_-|corrinoid-ABC-transporter-substrate-binding-protein
MIKKIFWIILAAAVILLLGGCNGPETTENPADSPAANAAVKDSAGREIKMPANLKRVIVLNSSAFNMITAIGAADTIIGVNDSTQKSEAAAAGKEAFGSFMQPYVEKIIAAGPDAVIVNSMMNSTQVKQLEDAGITVISLEFYLPSILQDEIVTLGKLFNREAQAQKYADFIMKYRNLIESRVKDIRPENKVAVYFEGYSEYSTVARGSGGDELVTGAGGINIAGRETVKYPKVSAEWVLEKKTSGGCKDHFQQ
>AP018449.1|BBB89393.1|30250_31033_-|putative-siderophore-transport-system-ATP-binding-protein-YusV
MNIAVQNVCFAYKSHPILQDVSLEVQKGQVVSIVGPNGAGKSTLLKCMVRLLKPQAGAVYLDGKDIAGKKSQELAKAMGYIPQNVKDAFPFTVLETVLLGRKPHITWEVNDDDFRVVSEVMHFLKIENLAERPLDQLSGGQKQKVFVARALAQQPEIFLFDEPTSNLDIRHQLEVFATIKRLAATEGRTVIVVVHDLNLAARFSDTLIMLKHGSIYAAGKPAEVITEASLREVYNVSAAIVETQYGCYVLPIEPLAETTG
>AP018449.1|BBB89394.1|31073_32180_-|hemin-transport-system-permease-protein-HmuU
MPDDSSSISPRADATKLKAIYARQTGKKYFIIVSLILLMATLALFSISIGAASISTGDVVKAIGNKLFHTQFEYANNLADTIVMKLRLPRVLLAVLTGISLAGAGAVMQGILHNPLVSPYTLGMSGAASLGAAVAIVLGKGLLGSSFVSMGPCFIAFNAFIFGFVTIFIIIGFARMKGGSPATLVLAGVALGYIFSAGVSALKYFSNNEALKDLVVWLMGGMWGATWQSVSLLVPIVSISMLILLSYAWDMNALSAGEAVAINLGVNIKRLQFICLTVATLAASATVAFTGIIGFIGLISPHISRMLIGSDNRFLIPCSCIMGALILLCADTVGRTVISPVEIPVGIVTGLLGGPYFLYMLLKKKQFY

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Crispr_ID: AP018449_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018449_4

3002509-3003004

TypeIII

Consensus_repeat	Method
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	PILER-CR
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	CRISPRCasFinder
GTTGTGAAAGCCGCTAAGCGGCATTGAAACNNN	CRT

7 spacers

csx1,cmr1gr7,cas10,cmr3gr5,csm6,cmr4gr7,cmr5gr11,cmr6gr7,cas6

The CRISPR arrays of AP018449_4

>merge|AP018449|4|3002509-3003004|PILER-CR,CRISPRCasFinder,CRT
GTTGTGAAAGCCGCTAAGCGGCATTGAAACCTTTCACAGCGGAACCAAAGGGAAACACGCCTTGCTGGGTTGTGAAAGCCGCTAAGCGGCATTGAAACTCGATTTCGCCTTCCTGGTCTTCAATAATTTGCTTGGGTTGTGAAAGCCGCTAAGCGGCATTGAAACTCACCTACTGTTTGACCAATTTCCGTAGGCGACGCGTTGTGAAAGCCGCTAAGCGGCATTGAAACGACAATTCTATAGGTGCCCAGCAAGATATTCTTGGTCAGTTGTGAAAGCCGCTAAGCGGCATTGAAACTCGGTTTCTTGAAGCATGCTCCGTGCCAGCCGATAAGTTGTGAAAGCCGCTAAGCGGCATTGAAACAAATTAGCCCGAAGGCTGTATTTAAGCACATTCCCTGTTGTGAAAGCCGCTAAGCGGCATTGAAACTTTGTAAGACAGATGATAATCTCTGTCTTCATAGGGGTTGTGAAAGCCGCGCTTTGTTGAAATTGA

>AP018449|4|3|3002509-3002938|PILER-CR
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	CTTTCACAGCGGAACCAAAGGGAAACACGCCTTGCTGG
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	TCGATTTCGCCTTCCTGGTCTTCAATAATTTGCTTGG
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	TCACCTACTGTTTGACCAATTTCCGTAGGCGACGC
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	GACAATTCTATAGGTGCCCAGCAAGATATTCTTGGTCA
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	TCGGTTTCTTGAAGCATGCTCCGTGCCAGCCGATAA
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	AAATTAGCCCGAAGGCTGTATTTAAGCACATTCCCT
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC

>AP018449|4|4|3002509-3002938|CRISPRCasFinder
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	CTTTCACAGCGGAACCAAAGGGAAACACGCCTTGCTGG
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	TCGATTTCGCCTTCCTGGTCTTCAATAATTTGCTTGG
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	TCACCTACTGTTTGACCAATTTCCGTAGGCGACGC
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	GACAATTCTATAGGTGCCCAGCAAGATATTCTTGGTCA
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	TCGGTTTCTTGAAGCATGCTCCGTGCCAGCCGATAA
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	AAATTAGCCCGAAGGCTGTATTTAAGCACATTCCCT
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC

>AP018449|4|3|3002509-3003004|CRT
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	CTTTCACAGCGGAACCAAAGGGAAACACGCCTTGCTGG
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	TCGATTTCGCCTTCCTGGTCTTCAATAATTTGCTTGG
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	TCACCTACTGTTTGACCAATTTCCGTAGGCGACGC
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	GACAATTCTATAGGTGCCCAGCAAGATATTCTTGGTCA
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	TCGGTTTCTTGAAGCATGCTCCGTGCCAGCCGATAA
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	AAATTAGCCCGAAGGCTGTATTTAAGCACATTCCCT
GTTGTGAAAGCCGCTAAGCGGCATTGAAAC	TTTGTAAGACAGATGATAATCTCTGTCTTCATAGGG
GTTGTGAAAGCCGCGCTTTGTTGAAATTGA

Protein	Signature genes	Signature genes Name	Protein_function
AP018449.1\|BBB92067.1\|3013413_3014223_+\|hypothetical-protein	cas6	pfam10040_cas6_CAS-III:CAS-IV	gnl\|CDD\|273848
AP018449.1\|BBB92050.1\|2995156_2995666_+\|iron-sulfur-protein	unknown	unknown	gnl\|CDD\|319885
AP018449.1\|BBB92057.1\|3001876_3002257_+\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB92062.1\|3008454_3009522_+\|CRISPR-associated-protein	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
AP018449.1\|BBB92063.1\|3009521_3010673_+\|CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
AP018449.1\|BBB92051.1\|2995752_2996508_-\|NADP-reducing-hydrogenase-subunit-HndC	unknown	unknown	gnl\|CDD\|181037
AP018449.1\|BBB92059.1\|3004896_3005292_+\|CRISPR-associated-protein	csx1	pfam09670_csx1_CAS-III	gnl\|CDD\|187878
AP018449.1\|BBB92049.1\|2993205_2995143_+\|carbon-monoxide-dehydrogenase-2	unknown	unknown	gnl\|CDD\|238896
AP018449.1\|BBB92058.1\|3003896_3004892_+\|CRISPR-associated-protein	csx1	pfam09670_csx1_CAS-III	gnl\|CDD\|187878
AP018449.1\|BBB92048.1\|2991952_2992888_+\|endonuclease-IV	unknown	unknown	gnl\|CDD\|224007
AP018449.1\|BBB92053.1\|2998309_2998804_-\|NADP-reducing-hydrogenase-subunit-HndA	unknown	unknown	gnl\|CDD\|376507
AP018449.1\|BBB92054.1\|2999062_2999224_+\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB92061.1\|3006758_3008453_+\|CRISPR-associated-protein	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
AP018449.1\|BBB92066.1\|3012084_3013236_+\|cold-shock-like-protein-CspC	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	gnl\|CDD\|187792
AP018449.1\|BBB92060.1\|3005826_3006762_+\|hypothetical-protein	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|224286
AP018449.1\|BBB92052.1\|2996520_2998323_-\|NADP-reducing-hydrogenase-subunit-HndC	unknown	unknown	gnl\|CDD\|224806
AP018449.1\|BBB92055.1\|2999567_3000761_+\|tetracycline-resistance-protein,-class-B	unknown	unknown	gnl\|CDD\|340949
AP018449.1\|BBB92064.1\|3010690_3011644_+\|RAMP-superfamily-protein	cmr4gr7	COG1336_cmr4gr7_CAS-III-C	gnl\|CDD\|274210
AP018449.1\|BBB92056.1\|3000896_3001655_+\|adenosine-monophosphate-protein-transferase-and-cysteine-protease-IbpA-precursor	unknown	unknown	gnl\|CDD\|225718
AP018449.1\|BBB92065.1\|3011663_3012101_+\|CRISPR-associated-protein	cmr5gr11	pfam09701_cmr5gr11_CAS-III-B	gnl\|CDD\|378242

Protein	Function_ID	Function_description	E-value
AP018449.1\|BBB92067.1\|3013413_3014223_+\|hypothetical-protein	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	7.2479e-17
AP018449.1\|BBB92050.1\|2995156_2995666_+\|iron-sulfur-protein	gnl\|CDD\|319885	cd10563, CooF_like, CooF, iron-sulfur subunit of carbon monoxide dehydrogenase. This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.	3.41259e-55
AP018449.1\|BBB92062.1\|3008454_3009522_+\|CRISPR-associated-protein	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	2.68612e-63
AP018449.1\|BBB92063.1\|3009521_3010673_+\|CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	7.11304e-29
AP018449.1\|BBB92051.1\|2995752_2996508_-\|NADP-reducing-hydrogenase-subunit-HndC	gnl\|CDD\|181037	PRK07569, PRK07569, bidirectional hydrogenase complex protein HoxU; Validated.	1.31124e-36
AP018449.1\|BBB92059.1\|3004896_3005292_+\|CRISPR-associated-protein	gnl\|CDD\|187878	cd09747, Csx1_III-U, CRISPR/Cas system-associated protein Csx1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; Some proteins could have an additional fusion with RecB-family nuclease domain; Core domain appears to have a Rossmann-like fold; loosely associated with CRISPR/Cas systems; also known as Cas02710 family.	3.74229e-11
AP018449.1\|BBB92060.1\|3005826_3006762_+\|hypothetical-protein	gnl\|CDD\|224286	COG1367, COG1367, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	7.93252e-15
AP018449.1\|BBB92058.1\|3003896_3004892_+\|CRISPR-associated-protein	gnl\|CDD\|187878	cd09747, Csx1_III-U, CRISPR/Cas system-associated protein Csx1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; Some proteins could have an additional fusion with RecB-family nuclease domain; Core domain appears to have a Rossmann-like fold; loosely associated with CRISPR/Cas systems; also known as Cas02710 family.	2.47173e-29
AP018449.1\|BBB92048.1\|2991952_2992888_+\|endonuclease-IV	gnl\|CDD\|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	1.06005e-31
AP018449.1\|BBB92053.1\|2998309_2998804_-\|NADP-reducing-hydrogenase-subunit-HndA	gnl\|CDD\|376507	pfam01257, 2Fe-2S_thioredx, Thioredoxin-like [2Fe-2S] ferredoxin.	7.1373e-65
AP018449.1\|BBB92055.1\|2999567_3000761_+\|tetracycline-resistance-protein,-class-B	gnl\|CDD\|340949	cd17391, MFS_MdtG_MDR_like, Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.83281e-172
AP018449.1\|BBB92061.1\|3006758_3008453_+\|CRISPR-associated-protein	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	1.35877e-55
AP018449.1\|BBB92066.1\|3012084_3013236_+\|cold-shock-like-protein-CspC	gnl\|CDD\|187792	cd09661, Cmr6_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.43977e-44
AP018449.1\|BBB92049.1\|2993205_2995143_+\|carbon-monoxide-dehydrogenase-2	gnl\|CDD\|238896	cd01915, CODH, Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to that of hybrid cluster protein (HCP) and a Ni-Fe-S center (C-cluster) where carbon monoxide oxidation occurs. Bifunctional CODH forms a heterotetramer with acetyl-CoA synthase (ACS) consisting of two CODH and two ACS subunits while monofunctional CODH forms a homodimer. Bifunctional CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP), while monofunctional CODH oxidizes carbon monoxide to carbon dioxide. CODH and ACS each have a metal cluster referred to as the C- and A-clusters, respectively.	0
AP018449.1\|BBB92052.1\|2996520_2998323_-\|NADP-reducing-hydrogenase-subunit-HndC	gnl\|CDD\|224806	COG1894, NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion].	0
AP018449.1\|BBB92064.1\|3010690_3011644_+\|RAMP-superfamily-protein	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	9.68462e-70
AP018449.1\|BBB92056.1\|3000896_3001655_+\|adenosine-monophosphate-protein-transferase-and-cysteine-protease-IbpA-precursor	gnl\|CDD\|225718	COG3177, COG3177, Fic family protein [Function unknown].	7.49055e-34
AP018449.1\|BBB92065.1\|3011663_3012101_+\|CRISPR-associated-protein	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	3.61804e-41

>AP018449.1|BBB92057.1|3001876_3002257_+|hypothetical-protein
MSEELLTKILEKLVRIEASMATKQELAEVKTELQADIGRVETELKTGIDRVETELKTDINRVKTELKADIAALDAKMEKGFADIVGMVNLLGEKTEAVLRIETKLSILAEQSLDHETDIRLLKKAR
>AP018449.1|BBB92056.1|3000896_3001655_+|adenosine-monophosphate-protein-transferase-and-cysteine-protease-IbpA-precursor
MDGINQTLKKIDHNQISINQNRPLEQTQVKNLKNYFKIGLTYASNALEGNTLTESETKVVIEEGITIGGKPLKDHLEAIGHARAFDYLWELAKSADITENDIKELHKICFQPKDGAAAGQYRQVDVIITGSHHNDKLSRHEDVPAHMRDFAAQLPEKRARLHPVVYAATLHRDFIYIHPFEDGNGRTARLLMNHALLATGYPPVIISPAFKHEYIQALEKSHSNSQMFTHYIAEQVLQAQRDYIRLLHLPPV
>AP018449.1|BBB92055.1|2999567_3000761_+|tetracycline-resistance-protein,-class-B
MENWKRNLMVCWFGVLATSAGLSQLTPILPLYIDQLGIHNFQDIERWSGIAYGITFIFMAVFSPLWGQAADKYGRKPMLLRASLGMAVVLTAMGFVQNIYQLVGLRLLQGTIAGFYSASITLIATQTPREHSGWALGTLSTGAVAGMLLGPLLGGYLAEIMGIRSVFFAIGALLLIAFAASLLFVQEEFTPPHKEALSFNKVWQLIPNPTVIVAMFVTTLILQLALMSIQPIITVYIAQLSTNTSHVALVSGMVFAATGLSSILAAPGLGKLADKIGPQKVMLAALIMAGISFIPQAFVQSSWELMGLRFLTGIATAGLLPAINCLVKNSTPDEIAGLVFGYNQCAQFLGSFLGSVLGGVVAATFGIHYVFFFTSVLLLLNATWVYKTVYSSKAACS
>AP018449.1|BBB92054.1|2999062_2999224_+|hypothetical-protein
MRNKRKEKVSVTPTALSMVPFLGPAVVVRNVILWGCFLPWCLLTFVSEANNQW
>AP018449.1|BBB92053.1|2998309_2998804_-|NADP-reducing-hydrogenase-subunit-HndA
MSTAKSSADFTATREIMRKYPREQRYTLAILQDIQREYSYIPKESLTLLSEYLAAPLSKLYSMSTFYKALSLKPKGEHIVKICDGTACHIRSSMVIADEIEKLIHIKPGETTDDGRFSLETVNCLGACAIAPVMVINETYYGKVTPAAVKEILSEYGGLTGGRE
>AP018449.1|BBB92052.1|2996520_2998323_-|NADP-reducing-hydrogenase-subunit-HndC
MDANRKKTVLVCCGTGCLANNSLEIYTGLKQRVLAAKLAVAVEPVLKSTGCNGFCEKGPIVKILPDDVSYYKVQPADVEEIFTASILNNEVIDRLLYLNITTGKRVKSQKDNEFYKQQMKLALRNIGEIDPANIDDYIARDGYQGLKKALLEMTPLAVIAEVKASGLRGRGGAGFPTGQKWQQCASYDSFPKYAVCNGDEGDPGAFMDRSIMEGDPHTVIEGMLIGGYAIKAETGYIYIRDEYSLAIRNMALAIEKAKGRGFLGRNILGSGFNFDLHIVRGGGAFVCGESTALMASIEGNVGEPRAKYVRSVEKGLWGQPTVLNNVETWANIPLILSNGSQAFQSIGTENSTGTKVFSLVGKVKNTGLVEVPMGVTLRHLIFDIGGGVIGNKKFKAVQSGGPSGGCIPESLLDLRVDFDTLTAAGSMMGSGGMIVMDERTCMVDVARYYVNFLAEESCGKCVPCREGLTRMREILNDICRGEGRPGDIELLEEICAMTGEAALCGLGKSAPNPVVSTIEHFKDEYLAHIVDKRCPAGICKDLTAYYINQSSCIGCGLCAKNCPAGAISGQLKTPHTLDMKLCIKCGNCIDSCKFDAVQVG
>AP018449.1|BBB92051.1|2995752_2996508_-|NADP-reducing-hydrogenase-subunit-HndC
MNITIDGKICQAEYGEFILAIAKRNDIHIPTLCHNDALPGQASCRLCIVDIVENGRNKVVTACVYPVTKEIEVITNSPKILNMRKTILMLLAARVPANEHLNKLIAEYSVSPVQRFASDPGEQCILCGLCVKACETVGLAAISTVSRGITKKVSTPYDEPSLSCIGCGACAQVCPTGAIKIVAAGKSRTIWNKNFELIKCEECGKYFATREQLEYINTKLGLADEDTLRLCEDCKTALVCEKFKNLYAANS
>AP018449.1|BBB92050.1|2995156_2995666_+|iron-sulfur-protein
MQKEILIRPERCMGCHSCEIACTVAHSPTKTLVGALLTDKPPRKQIYVEQVDGFKAPIACRHCEDAPCVDICMTHSLHRTPDGRVTNSDRLSKCLGCWMCIMACPFGVIRKDGDERRAVKCDRECLDETDSPACVRACPTGALVYATVADFAAVKRRSQVPLLTAAGKE
>AP018449.1|BBB92049.1|2993205_2995143_+|carbon-monoxide-dehydrogenase-2
MEAMKAKKAVKATDCAVGEMLEVARKQGIETVWDRYARQIPQCGFGDSGLCCRNCTQGPCRIDPFGDGPAAGVCGITADSMVARNLIRAIAAGAASHSGHAKHLAHVLKKVAAGKLTDYSVKDENKLRAVATRLGIPTEGKSVQELAAAVASAALEEFSEREEPLAWAATTLTSSQVEKLGGLGVLPAGIDSAISEILQRTTLGVDADPVNLLLGGVKGAVADFAGCHLGTDLADILFGTPTPVFSEANMGVLKENAVNIALHGHNPVVSELIVVAARQEDILAQAKSAGAEGINLVGICCTGNEVLMRQGVAPLTHSLSQEMPILTGALDAIVVDYQCVYPSLANIADCYGTKLITTMDIAKIPGAVHMAIEEERGLEQAKEIIKLAVERFKARKGAPTCIPQVKQKVIAGFSTEAIIGALSKLNAADPLKPLIDNIVNGNIQGVVLFAGCNNVKVPQDANFIAIVKELAKRDVLMLATGCGAGALARHGLLTSEATMEYAGPGLKAVFTAIGEANGLGGPLPLVLHVGSCVDNSRPVDIAVALANKLGVDVNQLPVAASAPEFKAEKAVAIGTWAVTLGLPTHLGLVPPVLGSKLVTRVLTQDIKDITGGYFLVETDPLLAAEKIFDALQERRQKLNIGTRRW
>AP018449.1|BBB92048.1|2991952_2992888_+|endonuclease-IV
MRVKGIAINADAGMLDGNLEVLNRELQYFRDLGFSHVEIAPHGVGVIYNGIINRTRMAELLQILWQYPFRYVVHAPNAMNLMNMDDGVTERNLFEATIEFTTTIGAAVMVYHAGRFLPEEKFMLTGQEILTPLKRAAMWEREKTMLYELGDIAAEHGLTIAVENTRPYLEARHYCYGETLDQLAAMMRQIDHPQVGVALDAGHAYLTACHYQYDLLAGVEALAPYVRHIHLHDNFGKCCTYFAKKQQYELTATGRGDMHMPIGWGAVPVREILTRLPNYHGVVTLEIHPRYRAYYGEALRNTQELLECITD
>AP018449.1|BBB92058.1|3003896_3004892_+|CRISPR-associated-protein
MTKRNKNKVLFVTVGGSPEPVITTIRYHKSEYIVFFASSDGFPVKTPGTHRLVDGEDNPWEVKLKNGQIERRPSIVVHTGLRPDQYEKVNITNVDSMDYCYRTIYNKILDVISLYPDADWIADYTGGTKTMGAALAIAAVDLGVKLNLVIGERINTVKVKDGTQRTVLTSCNTAIWNRYLKQIESSFTQRDYVSCQSLVEGVREEFNIDSKQDRLLQAFHSMARGFRAWDTFDHAAALDILRLYDRYIPQYMMFLDDIIKSKAITDLTNREPRYGLKSIAPVHDLLLNAQRRFEAGQYDDGIGRVSLSGIRTPRANVLGCLSASTTFYWTY
>AP018449.1|BBB92059.1|3004896_3005292_+|CRISPR-associated-protein
MLLPENLRANYDEPIKTKLGGDKIQIGLMEGYKLLINLGLPKNAVEELSKKLKSLNNYLMIRNYSILAHGFIPVERVKADEFYQYAVEITQIIERAEKLRSYVDCPQFPSSLPEKLYADIENWDSISSFSK
>AP018449.1|BBB92060.1|3005826_3006762_+|hypothetical-protein
MQRILINCNVLTPMFITGVDGRTPELRPASLKGVLRFWWRAVQLEEETKELCQRESSLFGGATQETGRSKIFLQISSPSGLNTNPYPPLPHHTGRTGCKPCLDKDIYECKKNSKIPAIDLNQNFCILLKYIDLPEYFSTDQLISLCKLIAALSGLGKRSRRGFGSFTVTAIAGIPVSPFITIEDIYKWLQDLAPEKYKLDNDIIRLTAECWAKYPFIEEIQIGREYDSVDNLAKTIGMASHDWDSDYTGFNRRQDPNDRKQKLQRMASPIHVSIIKSQQGFRPVITSLHTEFPPGWKSNDPMSEEFKGAIL
>AP018449.1|BBB92061.1|3006758_3008453_+|CRISPR-associated-protein
MIQFLFLFTITPVQSFISQARKTQDLYAGSYILSHLCRTGARWVEHHLKGEILFPEIHNQSIPNRFLAVLTASKEDLLRIGGEVEEVVRQEMRTISDSILNSLSLDKPADFDRQINSYFQIYWTFYPYNEPQYCQCFEQIEKLLGSVKNTKKFEQLSQESGRKCSITGEHNVQFYREKGQAYIPAGAVQVPGSLSLKYLGRKESLGAIAFVKRCADKYFTCPSSQYDKKFPSTAAIALMETENQLKKKRHDDIHISEPHMVFSLRNKQPFDDDCTPEAKVQAQNLLKLLETEKINFSSYYAVMLYDGDNMGKWLSGEYLNSQDGQREFHRSLSSQLGIFALKASREILIEPKGKAVYAGGDDFLGFINITHMLPVLKEMRNSFDRTIDLSCFSDEHLTFSAGVVIAHIKTPLSEVLAWVRKMEHEAKSIDINKNAIGLAVLKHSGEIHKTVLKWRYDERCTVTLLATVVKALQEENISESFIKSMGIEFGRIMDDDQPVIDDKLVKTEVRRLIYRSATSKKNSQWDDAKIDEFCENLYQLYLDGGRLERFLSFLSIARFLAREV
>AP018449.1|BBB92062.1|3008454_3009522_+|CRISPR-associated-protein
MIIEIRALDTLFFRDGKPFTMGAETWANGIFPPAPSVLYGALRSAYFAQHPEALAKVNSADDPTAGLVIRGYYLKIGEFVHFLLPGDCVVWDKDGAKVAGTMALQPNEELSSCPLPYMLAPAVQNRTESIEDGLLDDLTFEEYLDGFSTHYCFKKMHDYVLTEAKIGIARSYDTRTTEESRLYRIGMRRLESSLRRGRKTSAVSMVIDFSGMDLLREGIIRLGGEGKAALYQETTPYSIPKVLLQGRLFKLYLATPAIFENGWVPGWIDSVTMTGTYNGVNMRLICAAIGKFHSLGGWDMDKCKPKPMRRAVPAGSVYYFETETTPDLVLDVFHGQSISDYDAPQGFGIAYVGAV
>AP018449.1|BBB92063.1|3009521_3010673_+|CRISPR-associated-protein
MKRIVTTVGASIFENYKHQHLDFGDLYARVQRPHTEWEGLKPRIERIKKAVLPWAQNNDIASAEISSILKIERELGETADIIFLATDTVDSRLAAEIIFEAMLAWPGDRNVVFNPKEDIIAGLQVENCKTLERDGLPNLIECLYKIIQETYFENTVFNITGGYKAIIPCMTIMAQVNKIPIYYTFERTNELIRIPQAPIEIDYGIFEKYSHVLGDLKKGIEEDWKHYCYKHNIGEDIKNCVWEEEGMAALNSIGQIFWQRYQSFIFIEVPRGGKYFTENDPNVKRELNRAIRQMFSDISNFNFEIQTLRHDQIKHVAIEDTYVYKSTNPPFRIQYKITPGKKIRLINYCYINSDHVHDRYEALLREEYNIWRKADYTVVSFPK
>AP018449.1|BBB92064.1|3010690_3011644_+|RAMP-superfamily-protein
MYKIAKPLFLLCDTPLHAGSGNDLGIVDLPIQRERHTGFPKVESSGIKGCIRESFEVRQRDGKTFMANGNKVSGDDLKKCIELVFGPEGYNADEHAGALGFTDARVLLFPVKSMQGVFAWITCPKVLQRFQSDLKQCERIELGFTLPGESCASQECQLFIRNNPDVVILEEYSLEIKHKNDENCTALAKWLADHVVPQGEAFDYWRCKMAKDILVVSDDEFRDFVTLSTEVITRIKIDPVKGIVEKGALFTEEYLPSETVLYSLALATPIFAKNKGCFTQADRPEAAVMQFLVDGLEGVLQLGGNATIGKGITQICI
>AP018449.1|BBB92065.1|3011663_3012101_+|CRISPR-associated-protein
MIQQINSIKGLEMGRASFAYEKVEDAVEKLTKNDAKKYKSYVKKIPMYIKTNGLGPTLAFIRSKTDPDPAKSDTVYAMIYNQTTQWLKQDPKRVIIVNNDLVKTIISLRSPEYRAATVEVLSLFNWLRRFAEGLIEGEADDDIAG
>AP018449.1|BBB92066.1|3012084_3013236_+|cold-shock-like-protein-CspC
MILQGKIKFYNEQRGFGKIITPKDEEVFFHFTAFPRGTQHQIVEGLEVEYEVGIGQNGRPAAIKVWLIGQYQGQKGQRTNKQYFSDQVVQKGHERGGALKGQEIENIEYYLPEDTRKYVNIQTIDNYALRLNKTPYFSDGKFLFFRVKRKDASGVEVLPKFDNIPFENLILRQRNTQKKMGLAVKELSVKGNWRLVIGLGSASVYETSITLHGIYGFPYLPGSSLKGTVRSYIIQECFGGEEKGSQTAALRDEGFRAIFGGIADGDFKAIQGGIIFFDALPKEAPKVKTDIMNPHFGPYYSSSGDKPPTDYYNPVPVPFLVVEKTRYQIAIGITKEKNQVVKDGVFNGRWPLDVAEEYTLKVLEECGIGAKTAVGYGIMEKTD
>AP018449.1|BBB92067.1|3013413_3014223_+|hypothetical-protein
MTVNASELTALVLSLKSLNTASLPATHGAMAYAAALDMIGRFDPALTVRLHDTNARKPLTVSPLFGPVRRGREVPLTAGQAVRWRLCGLNAEISAALVQAAIAGSGVRIGDAVFEIDGATTAVEEDADAGNDTFSGLLQATTEAPVEITLSFITPTCFRQRNFELPFPLPRLLWGSLLDAWNAFSPELIDETRYSIEDALYITNYIAETCRADLGNRSAVGFVGKFSYRVVNNYLPLRLLLNLLARFAFYAGAGWQTTCGLGQVRPYFR

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Crispr_ID: AP018449_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018449_5

3015750-3016510

TypeIII

Consensus_repeat	Method
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	PILER-CR
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CRISPRCasFinder
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CRT

11 spacers

cas6,cmr6gr7,cmr5gr11,cmr4gr7,csm6,cmr3gr5,cas10

The CRISPR arrays of AP018449_5

>merge|AP018449|5|3015750-3016510|PILER-CR,CRISPRCasFinder,CRT
GTTGTGAAAGCTGCTATGCAGCATTGAAACACAACCGCTATTGGGGTCACGAGAACGAGGCCCCATGTTGTGAAAGCTGCTATGCAGCATTGAAACGATATATTGATCAGTACGAAAAACTCAAAGGTGAAAGTTGTGAAAGCTGCTATGCAGCATTGAAACTGGGGACTTCCTGACCGCATCGTTATCCCGGAAGGGTTGTGAAAGCTGCTATGCAGCATTGAAACATAATATACTGCTGCAGCATGGTATCCGTAAGAATAAGTTGTGAAAGCTGCTATGCAGCATTGAAACTGAATGATATCCGGGAGTTTAAACATGTTTCAACTACGTTGTGAAAGCTGCTATGCAGCATTGAAACAAAAAAGTCATAAAACGACATCCATCCTGCATCGCTCCGTTGTGAAAGCTGCTATGCAGCATTGAAACTCTTTCCCCCTCCCTATATCGCAACCCCTCTCTTAGTTGTGAAAGCTGCTATGCAGCATTGAAACCGGCCTGCATAAAGAAATTGGTGAGGCTATGGTCTGTTGTGAAAGCTGCTATGCAGCATTGAAACCGGGAGGCGCATAATATTTGTAAGGCGCAAGTTTTTTGTCGTGAAAGCTGCTATGCAGCATTGAAACTCAATCTGACCCCATATTCCACAAGGCAGTCGAATCCTGTTGTGAAAGCTGCTATGCAGCATTGAAACCCCGATCGAGAGCGAGCAAGGCGGCATTTCTATGTCGGTTGTGAAAGCTGCTATGCAGCATTGAAAC

>AP018449|5|4|3015750-3016510|PILER-CR
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	ACAACCGCTATTGGGGTCACGAGAACGAGGCCCCAT
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	GATATATTGATCAGTACGAAAAACTCAAAGGTGAAA
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	TGGGGACTTCCTGACCGCATCGTTATCCCGGAAGG
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	ATAATATACTGCTGCAGCATGGTATCCGTAAGAATAA
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	TGAATGATATCCGGGAGTTTAAACATGTTTCAACTAC
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	AAAAAAGTCATAAAACGACATCCATCCTGCATCGCTCC
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	TCTTTCCCCCTCCCTATATCGCAACCCCTCTCTTA
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CGGCCTGCATAAAGAAATTGGTGAGGCTATGGTCT
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CGGGAGGCGCATAATATTTGTAAGGCGCAAGTTTTTT
GTCGTGAAAGCTGCTATGCAGCATTGAAAC	TCAATCTGACCCCATATTCCACAAGGCAGTCGAATCCT
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CCCGATCGAGAGCGAGCAAGGCGGCATTTCTATGTCG
GTTGTGAAAGCTGCTATGCAGCATTGAAAC

>AP018449|5|5|3015750-3016510|CRISPRCasFinder
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	ACAACCGCTATTGGGGTCACGAGAACGAGGCCCCAT
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	GATATATTGATCAGTACGAAAAACTCAAAGGTGAAA
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	TGGGGACTTCCTGACCGCATCGTTATCCCGGAAGG
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	ATAATATACTGCTGCAGCATGGTATCCGTAAGAATAA
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	TGAATGATATCCGGGAGTTTAAACATGTTTCAACTAC
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	AAAAAAGTCATAAAACGACATCCATCCTGCATCGCTCC
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	TCTTTCCCCCTCCCTATATCGCAACCCCTCTCTTA
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CGGCCTGCATAAAGAAATTGGTGAGGCTATGGTCT
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CGGGAGGCGCATAATATTTGTAAGGCGCAAGTTTTTT
GTCGTGAAAGCTGCTATGCAGCATTGAAAC	TCAATCTGACCCCATATTCCACAAGGCAGTCGAATCCT
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CCCGATCGAGAGCGAGCAAGGCGGCATTTCTATGTCG
GTTGTGAAAGCTGCTATGCAGCATTGAAAC

>AP018449|5|4|3015750-3016510|CRT
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	ACAACCGCTATTGGGGTCACGAGAACGAGGCCCCAT
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	GATATATTGATCAGTACGAAAAACTCAAAGGTGAAA
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	TGGGGACTTCCTGACCGCATCGTTATCCCGGAAGG
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	ATAATATACTGCTGCAGCATGGTATCCGTAAGAATAA
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	TGAATGATATCCGGGAGTTTAAACATGTTTCAACTAC
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	AAAAAAGTCATAAAACGACATCCATCCTGCATCGCTCC
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	TCTTTCCCCCTCCCTATATCGCAACCCCTCTCTTA
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CGGCCTGCATAAAGAAATTGGTGAGGCTATGGTCT
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CGGGAGGCGCATAATATTTGTAAGGCGCAAGTTTTTT
GTCGTGAAAGCTGCTATGCAGCATTGAAAC	TCAATCTGACCCCATATTCCACAAGGCAGTCGAATCCT
GTTGTGAAAGCTGCTATGCAGCATTGAAAC	CCCGATCGAGAGCGAGCAAGGCGGCATTTCTATGTCG
GTTGTGAAAGCTGCTATGCAGCATTGAAAC

Protein	Signature genes	Signature genes Name	Protein_function
AP018449.1\|BBB92067.1\|3013413_3014223_+\|hypothetical-protein	cas6	pfam10040_cas6_CAS-III:CAS-IV	gnl\|CDD\|273848
AP018449.1\|BBB92075.1\|3020855_3021758_+\|benzylsuccinate-synthase-activating-enzyme	unknown	unknown	gnl\|CDD\|274163
AP018449.1\|BBB92069.1\|3014809_3015052_+\|transcriptional-repressor-DicA	unknown	unknown	gnl\|CDD\|376540
AP018449.1\|BBB92062.1\|3008454_3009522_+\|CRISPR-associated-protein	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|187879
AP018449.1\|BBB92063.1\|3009521_3010673_+\|CRISPR-associated-protein	csm6	cd09742_csm6_CAS-III-A:CAS-III-D	gnl\|CDD\|187873
AP018449.1\|BBB92078.1\|3025140_3026937_+\|calcineurin-like-phosphoesterase	unknown	unknown	gnl\|CDD\|277318
AP018449.1\|BBB92068.1\|3014367_3014676_-\|HTH-type-transcriptional-regulator-PuuR	unknown	unknown	gnl\|CDD\|238045
AP018449.1\|BBB92072.1\|3017700_3018579_+\|putative-amino-acid-metabolite-efflux-pump	unknown	unknown	gnl\|CDD\|273359
AP018449.1\|BBB92080.1\|3027463_3027724_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|368388
AP018449.1\|BBB92079.1\|3027065_3027326_+\|Sec-independent-protein-translocase-protein-TatAd	unknown	unknown	gnl\|CDD\|184862
AP018449.1\|BBB92064.1\|3010690_3011644_+\|RAMP-superfamily-protein	cmr4gr7	COG1336_cmr4gr7_CAS-III-C	gnl\|CDD\|274210
AP018449.1\|BBB92073.1\|3018754_3019471_+\|hydroxyacylglutathione-hydrolase	unknown	unknown	gnl\|CDD\|293807
AP018449.1\|BBB92076.1\|3021761_3024134_+\|benzylsuccinate-synthase-alpha-subunit	unknown	unknown	gnl\|CDD\|153086
AP018449.1\|BBB92074.1\|3019546_3019891_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|119344
AP018449.1\|BBB92066.1\|3012084_3013236_+\|cold-shock-like-protein-CspC	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	gnl\|CDD\|187792
AP018449.1\|BBB92071.1\|3016896_3017619_+\|bifunctional-transcriptional-activator/DNA-repair-enzyme-AdaA	unknown	unknown	gnl\|CDD\|225117
AP018449.1\|BBB92077.1\|3024376_3025066_+\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB92070.1\|3015048_3015252_+\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB92061.1\|3006758_3008453_+\|CRISPR-associated-protein	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
AP018449.1\|BBB92065.1\|3011663_3012101_+\|CRISPR-associated-protein	cmr5gr11	pfam09701_cmr5gr11_CAS-III-B	gnl\|CDD\|378242

Protein	Function_ID	Function_description	E-value
AP018449.1\|BBB92067.1\|3013413_3014223_+\|hypothetical-protein	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	7.2479e-17
AP018449.1\|BBB92075.1\|3020855_3021758_+\|benzylsuccinate-synthase-activating-enzyme	gnl\|CDD\|274163	TIGR02494, PFLE_PFLC, glycyl-radical enzyme activating protein. This subset of the radical-SAM family (pfam04055) includes a number of probable activating proteins acting on different enzymes all requiring an amino-acid-centered radical. The closest relatives to this family are the pyruvate-formate lyase activating enzyme (PflA, 1.97.1.4, TIGR02493) and the anaerobic ribonucleotide reductase activating enzyme (TIGR02491). Included within this subfamily are activators of hydroxyphenyl acetate decarboxylase (HdpA), benzylsuccinate synthase (BssD), gycerol dehydratase (DhaB2) as well as enzymes annotated in E. coli as activators of different isozymes of pyruvate-formate lyase (PFLC and PFLE) however, these appear to lack characterization and may activate enzymes with distinctive functions. Most of the sequence-level variability between these forms is concentrated within an N-terminal domain which follows a conserved group of three cysteines and contains a variable pattern of 0 to 8 additional cysteines.	3.47447e-121
AP018449.1\|BBB92069.1\|3014809_3015052_+\|transcriptional-repressor-DicA	gnl\|CDD\|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	4.99998e-15
AP018449.1\|BBB92062.1\|3008454_3009522_+\|CRISPR-associated-protein	gnl\|CDD\|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	2.68612e-63
AP018449.1\|BBB92063.1\|3009521_3010673_+\|CRISPR-associated-protein	gnl\|CDD\|187873	cd09742, Csm6_III-A, CRISPR/Cas system-associated protein Csm6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Protein of this family often fused to HTH domain; loosely associated with CRISPR/Cas systems; also known as APE2256 family.	7.11304e-29
AP018449.1\|BBB92078.1\|3025140_3026937_+\|calcineurin-like-phosphoesterase	gnl\|CDD\|277318	cd00839, MPP_PAPs, purple acid phosphatases of the metallophosphatase superfamily, metallophosphatase domain. Purple acid phosphatases (PAPs) belong to a diverse family of binuclear metallohydrolases that have been identified and characterized in plants, animals, and fungi. PAPs contain a binuclear metal center and their characteristic pink or purple color derives from a charge-transfer transition between a tyrosine residue and a chromophoric ferric ion within the binuclear center. PAPs catalyze the hydrolysis of a wide range of activated phosphoric acid mono- and di-esters and anhydrides. PAPs are distinguished from the other phosphatases by their insensitivity to L-(+) tartrate inhibition and are therefore also known as tartrate resistant acid phosphatases (TRAPs). While only a few copies of PAP-like genes are present in mammalian and fungal genomes, multiple copies are present in plant genomes. PAPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	8.22039e-28
AP018449.1\|BBB92068.1\|3014367_3014676_-\|HTH-type-transcriptional-regulator-PuuR	gnl\|CDD\|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	6.32186e-15
AP018449.1\|BBB92080.1\|3027463_3027724_-\|hypothetical-protein	gnl\|CDD\|368388	pfam05327, RRN3, RNA polymerase I specific transcription initiation factor RRN3. This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.	0.000421839
AP018449.1\|BBB92079.1\|3027065_3027326_+\|Sec-independent-protein-translocase-protein-TatAd	gnl\|CDD\|184862	PRK14860, tatA, twin arginine translocase protein A; Provisional.	6.52395e-18
AP018449.1\|BBB92071.1\|3016896_3017619_+\|bifunctional-transcriptional-activator/DNA-repair-enzyme-AdaA	gnl\|CDD\|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	3.16227e-25
AP018449.1\|BBB92064.1\|3010690_3011644_+\|RAMP-superfamily-protein	gnl\|CDD\|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	9.68462e-70
AP018449.1\|BBB92073.1\|3018754_3019471_+\|hydroxyacylglutathione-hydrolase	gnl\|CDD\|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	3.4456e-23
AP018449.1\|BBB92076.1\|3021761_3024134_+\|benzylsuccinate-synthase-alpha-subunit	gnl\|CDD\|153086	cd01677, PFL2_DhaB_BssA, Pyruvate formate lyase 2 and related enzymes. This family includes pyruvate formate lyase 2 (PFL2), B12-independent glycerol dehydratase (DhaB) and the alpha subunit of benzylsuccinate synthase (BssA), all of which have a highly conserved ten-stranded alpha/beta barrel domain, which is similar to those of PFL1 (pyruvate formate lyase 1) and RNR (ribonucleotide reductase). Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. DhaB catalyzes the first step in the conversion of glycerol to 1,3-propanediol while BssA catalyzes the first step in the anaerobic mineralization of both toluene and m-xylene.	0
AP018449.1\|BBB92074.1\|3019546_3019891_+\|hypothetical-protein	gnl\|CDD\|119344	cd06552, ASCH_yqfb_like, ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation, RNA-processing and the regulation of prokaryotic translation.	1.63521e-07
AP018449.1\|BBB92066.1\|3012084_3013236_+\|cold-shock-like-protein-CspC	gnl\|CDD\|187792	cd09661, Cmr6_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr6. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	1.43977e-44
AP018449.1\|BBB92072.1\|3017700_3018579_+\|putative-amino-acid-metabolite-efflux-pump	gnl\|CDD\|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	6.19002e-20
AP018449.1\|BBB92061.1\|3006758_3008453_+\|CRISPR-associated-protein	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	1.35877e-55
AP018449.1\|BBB92065.1\|3011663_3012101_+\|CRISPR-associated-protein	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	3.61804e-41

>AP018449.1|BBB92070.1|3015048_3015252_+|hypothetical-protein
MTSMKFFWYVCDGEVEEYSGQEVNWNDSVIVFAKSPEDALLKVMKYHLGMLKRIGIVCDGKNIEIIS
>AP018449.1|BBB92069.1|3014809_3015052_+|transcriptional-repressor-DicA
MDVGIKIKQRRECLNFSQEQLSQISGVSQASIHYIEAGENSPTAKTLFKLASALGVSITELLGDQPATSKSQISADKSQG
>AP018449.1|BBB92068.1|3014367_3014676_-|HTH-type-transcriptional-regulator-PuuR
MPKIGRRLRDLRIQKKLTMKEVAEIAGIAQSSVSYIETGNNSPSIETLEAILTALGITIGEFFAEEKPELEPELRQLLDTAKKLTPEQRELAQRLLDALSKD
>AP018449.1|BBB92067.1|3013413_3014223_+|hypothetical-protein
MTVNASELTALVLSLKSLNTASLPATHGAMAYAAALDMIGRFDPALTVRLHDTNARKPLTVSPLFGPVRRGREVPLTAGQAVRWRLCGLNAEISAALVQAAIAGSGVRIGDAVFEIDGATTAVEEDADAGNDTFSGLLQATTEAPVEITLSFITPTCFRQRNFELPFPLPRLLWGSLLDAWNAFSPELIDETRYSIEDALYITNYIAETCRADLGNRSAVGFVGKFSYRVVNNYLPLRLLLNLLARFAFYAGAGWQTTCGLGQVRPYFR
>AP018449.1|BBB92066.1|3012084_3013236_+|cold-shock-like-protein-CspC
MILQGKIKFYNEQRGFGKIITPKDEEVFFHFTAFPRGTQHQIVEGLEVEYEVGIGQNGRPAAIKVWLIGQYQGQKGQRTNKQYFSDQVVQKGHERGGALKGQEIENIEYYLPEDTRKYVNIQTIDNYALRLNKTPYFSDGKFLFFRVKRKDASGVEVLPKFDNIPFENLILRQRNTQKKMGLAVKELSVKGNWRLVIGLGSASVYETSITLHGIYGFPYLPGSSLKGTVRSYIIQECFGGEEKGSQTAALRDEGFRAIFGGIADGDFKAIQGGIIFFDALPKEAPKVKTDIMNPHFGPYYSSSGDKPPTDYYNPVPVPFLVVEKTRYQIAIGITKEKNQVVKDGVFNGRWPLDVAEEYTLKVLEECGIGAKTAVGYGIMEKTD
>AP018449.1|BBB92065.1|3011663_3012101_+|CRISPR-associated-protein
MIQQINSIKGLEMGRASFAYEKVEDAVEKLTKNDAKKYKSYVKKIPMYIKTNGLGPTLAFIRSKTDPDPAKSDTVYAMIYNQTTQWLKQDPKRVIIVNNDLVKTIISLRSPEYRAATVEVLSLFNWLRRFAEGLIEGEADDDIAG
>AP018449.1|BBB92064.1|3010690_3011644_+|RAMP-superfamily-protein
MYKIAKPLFLLCDTPLHAGSGNDLGIVDLPIQRERHTGFPKVESSGIKGCIRESFEVRQRDGKTFMANGNKVSGDDLKKCIELVFGPEGYNADEHAGALGFTDARVLLFPVKSMQGVFAWITCPKVLQRFQSDLKQCERIELGFTLPGESCASQECQLFIRNNPDVVILEEYSLEIKHKNDENCTALAKWLADHVVPQGEAFDYWRCKMAKDILVVSDDEFRDFVTLSTEVITRIKIDPVKGIVEKGALFTEEYLPSETVLYSLALATPIFAKNKGCFTQADRPEAAVMQFLVDGLEGVLQLGGNATIGKGITQICI
>AP018449.1|BBB92063.1|3009521_3010673_+|CRISPR-associated-protein
MKRIVTTVGASIFENYKHQHLDFGDLYARVQRPHTEWEGLKPRIERIKKAVLPWAQNNDIASAEISSILKIERELGETADIIFLATDTVDSRLAAEIIFEAMLAWPGDRNVVFNPKEDIIAGLQVENCKTLERDGLPNLIECLYKIIQETYFENTVFNITGGYKAIIPCMTIMAQVNKIPIYYTFERTNELIRIPQAPIEIDYGIFEKYSHVLGDLKKGIEEDWKHYCYKHNIGEDIKNCVWEEEGMAALNSIGQIFWQRYQSFIFIEVPRGGKYFTENDPNVKRELNRAIRQMFSDISNFNFEIQTLRHDQIKHVAIEDTYVYKSTNPPFRIQYKITPGKKIRLINYCYINSDHVHDRYEALLREEYNIWRKADYTVVSFPK
>AP018449.1|BBB92062.1|3008454_3009522_+|CRISPR-associated-protein
MIIEIRALDTLFFRDGKPFTMGAETWANGIFPPAPSVLYGALRSAYFAQHPEALAKVNSADDPTAGLVIRGYYLKIGEFVHFLLPGDCVVWDKDGAKVAGTMALQPNEELSSCPLPYMLAPAVQNRTESIEDGLLDDLTFEEYLDGFSTHYCFKKMHDYVLTEAKIGIARSYDTRTTEESRLYRIGMRRLESSLRRGRKTSAVSMVIDFSGMDLLREGIIRLGGEGKAALYQETTPYSIPKVLLQGRLFKLYLATPAIFENGWVPGWIDSVTMTGTYNGVNMRLICAAIGKFHSLGGWDMDKCKPKPMRRAVPAGSVYYFETETTPDLVLDVFHGQSISDYDAPQGFGIAYVGAV
>AP018449.1|BBB92061.1|3006758_3008453_+|CRISPR-associated-protein
MIQFLFLFTITPVQSFISQARKTQDLYAGSYILSHLCRTGARWVEHHLKGEILFPEIHNQSIPNRFLAVLTASKEDLLRIGGEVEEVVRQEMRTISDSILNSLSLDKPADFDRQINSYFQIYWTFYPYNEPQYCQCFEQIEKLLGSVKNTKKFEQLSQESGRKCSITGEHNVQFYREKGQAYIPAGAVQVPGSLSLKYLGRKESLGAIAFVKRCADKYFTCPSSQYDKKFPSTAAIALMETENQLKKKRHDDIHISEPHMVFSLRNKQPFDDDCTPEAKVQAQNLLKLLETEKINFSSYYAVMLYDGDNMGKWLSGEYLNSQDGQREFHRSLSSQLGIFALKASREILIEPKGKAVYAGGDDFLGFINITHMLPVLKEMRNSFDRTIDLSCFSDEHLTFSAGVVIAHIKTPLSEVLAWVRKMEHEAKSIDINKNAIGLAVLKHSGEIHKTVLKWRYDERCTVTLLATVVKALQEENISESFIKSMGIEFGRIMDDDQPVIDDKLVKTEVRRLIYRSATSKKNSQWDDAKIDEFCENLYQLYLDGGRLERFLSFLSIARFLAREV
>AP018449.1|BBB92071.1|3016896_3017619_+|bifunctional-transcriptional-activator/DNA-repair-enzyme-AdaA
MSCLNNVTCERRTYTEKPHGHIHAFAQLVVPISGTLSVMIGEQSLADCCQNVIYIPPSSYHSFHSQGRNRFFVFDIPTFFLPKNKTLLADCLRMDGRWQAVRALLFDEVGESTASNPRLSDLCCYIMRLLEDKARHSASLEYMHSNYCRQITVQELAALEHYNPSYYCTWFLKHYGVSPLNYIRNLRLENAKDLLVNTDCTLMQIAQQIGYQHQSTLTRLFLAETGMAPAEFRRKNKSSG
>AP018449.1|BBB92072.1|3017700_3018579_+|putative-amino-acid-metabolite-efflux-pump
MGTDLRGPLFLSAAAGIWGGMYVVSKYALDTIPPFTLLFIRYFLAAVTLVWWSRLSGVNIIPRQDKGTLFQIGLFGYFLSLAAQFIGTKLSSAHMGAVITSLSPVFQSGFAILILGEKITARQMVAICLAFAGVLIVTGLPGFSNGDAFDSGTLFFLVAACLWGYYSVLTKKVADGVSPLQITTWGIILATLFSLPFAWWELTAWNVGDLVGLPILLSILYLAFFSTTIAYYCWNKGLLLMSPHKSGLFFFLQPVVGSILGYLILDEYLSISFFWGSLLILLGVYFVMKASN
>AP018449.1|BBB92073.1|3018754_3019471_+|hydroxyacylglutathione-hydrolase
MDYMTASIAPDIFVIAVDDTETWGMQTYTNLYVLKRKEQLVLIDAGSPVYVNLVKSALKDIGYKPDDFTHVLFTHGHHDHVGCAELFRKAQKRIHRGDLPLLAPHLAAEVMPYTVWPDERVGIDDLEWLDAVAVDYHTPGSTALYDHGSRALFAGDFFCFFGDPLPEGKLISYAGQYREACYKYVADQIAGGSAQMDDFRSGLERLMHYQPAFFCTGHGVILQDDIQDFVRGLWQNAV
>AP018449.1|BBB92074.1|3019546_3019891_+|hypothetical-protein
MFALNFQLPNHEKLLISRQKNCTIRLGDIRDAYPENSVVWITVGERFHQKHKLYMAVIDKVSIKKFSDLTTHDLDHQNPEIKTVEELLQFFATTYQKSVSPDDIVTVIYFSEIL
>AP018449.1|BBB92075.1|3020855_3021758_+|benzylsuccinate-synthase-activating-enzyme
MRKTLIFNIQKFCIHDGPGIRTTVFFKGCPLKCSWCHNPESQNSRQEMLYDKDKCSLCGQCARHCQVKAISITNGKILFDPHKCRLCKVCIDVCSNNAREIAGEEYSVAELMREIEKDRPFYEQSGGGVTLSGGEAMVQIDFVAELVATCRERGIAVAIDTCGQAPTENFLRIMEYVDIFLYDIKLLDPARHRDYTGQDNRLILDNLKVLSDQGANINLRLPLLAGVNDGPDHICRVIRLIQNFNISSINLLPYHDIGQGKYRKLARDYPAEGFDKPPAARVAEIKAAFEQENYQVKIGG
>AP018449.1|BBB92076.1|3021761_3024134_+|benzylsuccinate-synthase-alpha-subunit
METRGMNERIRKLRTQSLTAEPRLSMERAELVTAVYEKYSGTVETPILRALAFKHIMEEKALCINDGELIVGEKGETPQSAPTFPELCCHSLDDMAVMQQRDKIYFRVTAEAEKIQREKIIPYWQNRAMRKNILDRMAPAWMDCYESGIFTEFMEQRGPGHTVIDGKIYKKGFLDFKADIEREISNLNFLADEQAYDKKIQLEAMVICCDAIITYGKRYARYARELAAAESGQTRKAELWQIAANCEVVPAHKPATFAQAIQMYWFVHIGVTTEINPWDALSPGRLDQHLYPFYQQGIEAGSLTREQAKELLQCLWIKFNNQPAPPKVGITLKESGTYTDFANLNTGGVKADGSDGVNDISYLILETMDELKLLQPSSNVQISRKSPHLFVKKACEISRKGWGQPAFYNTEAIIQELLRAGKDIVDARQGGASGCVETGAFGKEAYILTGYFNLPKILELTLNNGFDPTVNKQLGLETGHAEDYKSYEELFAAYKKQLQYFVDVKVTGNHIIETLYAKHMPVPFLSVIISDCIKKAKDYNAGGARYNTNYIQGVGIGTLADSLAAIKYNVFDRKSFTMTELMQALADNFTGRKYIHNLVLNRTPKYGNDDDYADQIMIEAFEAFYQAVTGRKNRKGGVYRIDMLPTTCHIYFGSVMGASPNGRRAHKPLSEGISPDKGADRKGPTAVIKSASKMDHIKTGGTLLNQKFTPAVVAGEAGLENMAALIRTYFNLDGHHIQFNVIDRKTLLAAQSQPEEYKDLIVRVAGYSDYFHNLDKELQDEIIARTEQSF
>AP018449.1|BBB92077.1|3024376_3025066_+|hypothetical-protein
MKIKVGVAVLGAMVMANVALASPLTDYSTGKTALDVSFESPKITDDNDTYGSTGSVNGKSIVGFGITTGLGNKFALQYKQSSPRTKDVTTDVLNLGGGITSINSHETVDVNEYNLLYQINTNISVLAGVSQVKGKLQGDLSDNTNTRGLFQVGFVGSAPVADKTTAYTTAAFGNDLTTWKLGLSYQVDKNWEMDVYYGYNKYRNLQWQTDSSQSDFTIKGVGYGISYKF
>AP018449.1|BBB92078.1|3025140_3026937_+|calcineurin-like-phosphoesterase
MDKKDELLELVQKPGNISRRAFLKTAGSLAVLLSLPVDLRNVFAASPGASVAPDHVTLTWSGDPATTQTITWRTNTTVSNGVIQYSTTTTGRAALTNGVQTVTAALETLKSDLGDANLHSAMVSGLRPGTKYNYRVGDGVNWSSVSSFTTAVAGATSFKFLVFGDSQSGIIGTPEYTPWQNNVHAAYAANTDAKFFINVGDLTECGQNYVHWNNWYAACQDIINTIPAMPSEGNHETYSSNYNSGSPGWIPPSGSTAEPYEYVHQFKVPQNGPAGLNTQAYSWDFGNVHFAIIDSQYDEEVTAELKARFPGTTFLDLQKTWLENDLKNTQKQWKIVIFHKTPYYNKANRTNELLKTAFCPIIEKYNVDVVFNGHDHGISRTYPIKGDVFQNSPSKGTVYYVTGRSGNKYYTDLSKKVWDQFFYDANDMPGYVVAQVNGSSLTLKAVKQNGTVVDTYTINKASGTDSPATVLPAKYAATRVIVYGNDSNVNAVQNGSTRYIPLNFVKVGYTNSYTGGTPVSNLGVTNFTSSTTQAAFTYNQVSYTFTVGSTTVGGSTKTLTSPAILQDGMVMIKADDVTNVLGFAYRYDSSLNAIFLAK
>AP018449.1|BBB92079.1|3027065_3027326_+|Sec-independent-protein-translocase-protein-TatAd
MFSFAMPELILILVIALVVFGPGKLPELGKALGKGMQEFRRATGEVVEEKAINIEAKAIEEKNRLDKLPAAESERRAAGVNSQEQR
>AP018449.1|BBB92080.1|3027463_3027724_-|hypothetical-protein
MAYEKTVKYLVEKFQTALAPLNTISKNQEILIEQNHQIIDLLAKIHRLDTPEQEESEEELPIEDDSEDDSEDDSEDDSADDSSEEY

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Crispr_ID: AP018449_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018449_6

4694505-4694803

TypeIII

Consensus_repeat	Method
NNNNGTTTCAAATCCTTATAGGTAGGCTATAAAC	CRT
GTTTCAAATCCTTATAGGTAGGCTATAAACC	PILER-CR
GTTTCAAATCCTTATAGGTAGGCTATAAAC	CRISPRCasFinder

4 spacers

cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7

The CRISPR arrays of AP018449_6

>merge|AP018449|6|4694505-4694803|CRT,PILER-CR,CRISPRCasFinder
AACCATTTCAACCCAAGCTAGGCTATAAACTAAGAATTTGCTCCTTGAATCCATACTCTTTGGATCCGGTTTCAAATCCTTATAGGTAGGCTATAAACCGCAGGATGAAAAACCAATCGAAGCCTCACTTAGGAGGTTTCAAATCCTTATAGGTAGGCTATAAACATAGATACGCAGAGTGACGGCCACGGGCCAAAAACAAGTTTCAAATCCTTATAGGTAGGCTATAAACCGAAACAGCCGGTACAGCCTTGAATGCGCTGTTTACGTTTCAAATCCTTATAGGTAGGCTATAAACC

>AP018449|6|5|4694505-4694802|CRT
AACCATTTCAACCCAAGCTAGGCTATAAAC	TAAGAATTTGCTCCTTGAATCCATACTCTTTGGATCCG
GTTTCAAATCCTTATAGGTAGGCTATAAAC	CGCAGGATGAAAAACCAATCGAAGCCTCACTTAGGAG
GTTTCAAATCCTTATAGGTAGGCTATAAAC	ATAGATACGCAGAGTGACGGCCACGGGCCAAAAACAA
GTTTCAAATCCTTATAGGTAGGCTATAAAC	CGAAACAGCCGGTACAGCCTTGAATGCGCTGTTTAC
GTTTCAAATCCTTATAGGTAGGCTATAAAC

>AP018449|6|5|4694573-4694803|PILER-CR
GTTTCAAATCCTTATAGGTAGGCTATAAACC	GCAGGATGAAAAACCAATCGAAGCCTCACTTAGGAG
GTTTCAAATCCTTATAGGTAGGCTATAAACA	TAGATACGCAGAGTGACGGCCACGGGCCAAAAACAA
GTTTCAAATCCTTATAGGTAGGCTATAAACC	GAAACAGCCGGTACAGCCTTGAATGCGCTGTTTAC
GTTTCAAATCCTTATAGGTAGGCTATAAACC

>AP018449|6|6|4694573-4694802|CRISPRCasFinder
GTTTCAAATCCTTATAGGTAGGCTATAAAC	CGCAGGATGAAAAACCAATCGAAGCCTCACTTAGGAG
GTTTCAAATCCTTATAGGTAGGCTATAAAC	ATAGATACGCAGAGTGACGGCCACGGGCCAAAAACAA
GTTTCAAATCCTTATAGGTAGGCTATAAAC	CGAAACAGCCGGTACAGCCTTGAATGCGCTGTTTAC
GTTTCAAATCCTTATAGGTAGGCTATAAAC

Protein	Signature genes	Signature genes Name	Protein_function
AP018449.1\|BBB93480.1\|4695467_4695752_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93475.1\|4688247_4688346_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93486.1\|4701497_4702670_-\|CRISPR-associated-protein	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|370625
AP018449.1\|BBB93482.1\|4697629_4698820_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380122
AP018449.1\|BBB93488.1\|4704308_4705253_-\|hypothetical-protein	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|187788
AP018449.1\|BBB93469.1\|4682031_4682787_-\|lipoprotein-releasing-system-ATP-binding-protein-LolD	unknown	unknown	gnl\|CDD\|213222
AP018449.1\|BBB93476.1\|4688709_4692075_-\|ATP-dependent-DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|223288
AP018449.1\|BBB93470.1\|4683035_4684088_-\|biotin-synthase	unknown	unknown	gnl\|CDD\|180835
AP018449.1\|BBB93474.1\|4687285_4688302_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93485.1\|4700522_4701485_-\|RAMP-superfamily-protein	cmr4gr7	COG1336_cmr4gr7_CAS-III-C	gnl\|CDD\|224255
AP018449.1\|BBB93472.1\|4685201_4686266_-\|cyclic-di-GMP-phosphodiesterase-response-regulator-RpfG	unknown	unknown	gnl\|CDD\|225116
AP018449.1\|BBB93487.1\|4702662_4704309_-\|CRISPR-associated-protein	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
AP018449.1\|BBB93479.1\|4695048_4695321_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93478.1\|4692931_4694287_-\|multidrug-resistance-protein-NorM	unknown	unknown	gnl\|CDD\|240538
AP018449.1\|BBB93473.1\|4686611_4687289_+\|germination-specific-N-acetylmuramoyl-L-alanine-amidase-precursor	unknown	unknown	gnl\|CDD\|274337
AP018449.1\|BBB93483.1\|4698830_4700090_-\|RAMP-superfamily-protein	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	gnl\|CDD\|213662
AP018449.1\|BBB93481.1\|4695779_4696649_-\|putative-S-adenosyl-L-methionine-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|272862
AP018449.1\|BBB93484.1\|4700086_4700539_-\|CRISPR-associated-protein	cmr5gr11	pfam09701_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
AP018449.1\|BBB93477.1\|4692318_4692864_+\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93471.1\|4684182_4684995_-\|NAD-synthetase	unknown	unknown	gnl\|CDD\|224522

Protein	Function_ID	Function_description	E-value
AP018449.1\|BBB93471.1\|4684182_4684995_-\|NAD-synthetase	gnl\|CDD\|224522	COG1606, COG1606, ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only].	4.54105e-95
AP018449.1\|BBB93486.1\|4701497_4702670_-\|CRISPR-associated-protein	gnl\|CDD\|370625	pfam09700, Cas_Cmr3, CRISPR-associated protein (Cas_Cmr3). CRISPR is a term for Clustered Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family, found in at least ten different archaeal and bacterial species, is represented by TM1793 from Thermotoga maritima.	4.41336e-35
AP018449.1\|BBB93482.1\|4697629_4698820_-\|hypothetical-protein	gnl\|CDD\|380122	pfam18145, SAVED, SMODS-associated and fused to various effectors sensor domain. Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. The sensing of ligands by SAVED is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.	1.03129e-19
AP018449.1\|BBB93488.1\|4704308_4705253_-\|hypothetical-protein	gnl\|CDD\|187788	cd09657, Cmr1_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	2.42774e-12
AP018449.1\|BBB93469.1\|4682031_4682787_-\|lipoprotein-releasing-system-ATP-binding-protein-LolD	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	1.28936e-104
AP018449.1\|BBB93470.1\|4683035_4684088_-\|biotin-synthase	gnl\|CDD\|180835	PRK07094, PRK07094, biotin synthase; Provisional.	0
AP018449.1\|BBB93485.1\|4700522_4701485_-\|RAMP-superfamily-protein	gnl\|CDD\|224255	COG1336, COG1336, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.09579e-64
AP018449.1\|BBB93472.1\|4685201_4686266_-\|cyclic-di-GMP-phosphodiesterase-response-regulator-RpfG	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	1.45675e-70
AP018449.1\|BBB93487.1\|4702662_4704309_-\|CRISPR-associated-protein	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	6.17976e-60
AP018449.1\|BBB93478.1\|4692931_4694287_-\|multidrug-resistance-protein-NorM	gnl\|CDD\|240538	cd13133, MATE_like_7, Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	2.84162e-94
AP018449.1\|BBB93473.1\|4686611_4687289_+\|germination-specific-N-acetylmuramoyl-L-alanine-amidase-precursor	gnl\|CDD\|274337	TIGR02883, spore_cwlD, N-acetylmuramoyl-L-alanine amidase CwlD. Members of this protein family are the CwlD family of N-acetylmuramoyl-L-alanine amidase. This family has been called the germination-specific N-acetylmuramoyl-L-alanine amidase. CwlD is required, along with the putative deactylase PdaA, to make muramic delta-lactam, a novel peptidoglycan constituent found only in spores. CwlD mutants show a germination defect. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination].	1.27037e-69
AP018449.1\|BBB93483.1\|4698830_4700090_-\|RAMP-superfamily-protein	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	4.23676e-31
AP018449.1\|BBB93481.1\|4695779_4696649_-\|putative-S-adenosyl-L-methionine-dependent-methyltransferase	gnl\|CDD\|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	7.73285e-57
AP018449.1\|BBB93484.1\|4700086_4700539_-\|CRISPR-associated-protein	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	9.33494e-33
AP018449.1\|BBB93476.1\|4688709_4692075_-\|ATP-dependent-DNA-helicase-PcrA	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	5.02744e-129

>AP018449.1|BBB93478.1|4692931_4694287_-|multidrug-resistance-protein-NorM
MDRHIVSYRHIVQIAYPVTLSMLSMNAMIFVDRMFVSQYNLTQFAAMIPAGLFATSIASIFGGIVGYSSVLVSQYFGARRYNDCSASTWQAVYLSALFVVLLIVSSVGLENIFQVLGHDESLIHFEKEYFYLIISANCFQLFTTALSGLYYGIGDTRTTMHIEIFINVANMVLAWLLVLGKCGFPAMGMFGAGLATNISSAIGLAVYLLRLNQRSFKSRFQFFINFDFNKFLLHKIVKFGLFSGIQSFTITGYFSIFLLIIGMRGEFDLTCANIAVALQAASILPVYGITTAVGILAGQERGADRPDNLTIILKKGILISSCYVILIVIFFNLLPEFLISIFNSEHDKERLVLINNATIPLVRLTSICVALEMVFSTIGSALQAVGDTRFMMVTYTVIPFIFYVIMPYIICVRGSLSLEVLWIMLIGYRIIMLLVVTRRFVGGKWKAINVI
>AP018449.1|BBB93477.1|4692318_4692864_+|hypothetical-protein
MSNQVLLWLILILPLLTLFFMPKENIKRWTPVALFSALTSVIAVELGENLGWFIYEEAAYPLRTPSYIIFGLNIVVTIWSFHFLYGRFWRYIVIDTVLNFGFIYLFHVYFLGGRGLFHEVGLTPFLNTLIVTFDGVLAYGYQIWQEEIFVRSETKSADYASNLQPAAAKPLPENQDNEKSE
>AP018449.1|BBB93476.1|4688709_4692075_-|ATP-dependent-DNA-helicase-PcrA
MFIADFHIHSRYSRATSKDCVPEMLELWARRKGINVIGTGDFTHPAWREELKEKLVPAGEGLYILKNDFRKEDKIAGADFKPQFIVSGEISSIYKKNGRVRKVHNLILLPSLEYAELISHKLEAIGNLRSDGRPILGLDSRDLLEIVLDTCPEAIFIPAHIWTPHFSLYGAYSGFDDITECFGDLTGYIYALETGLSSDPPMNWRLSALDNFTLVSNSDAHSPANLGREANIFNTGLSYPCMLQALKNRNTKEFYGTIEFFPEEGKYHYDGHRACKVCWKPAETKAAGGICPVCGGRLTVGVLHRVEALADREEGFIPPVVKHFESLVPLNQVIASVLGSTVTSMKVKKKYDDLLRGLGPELFILREAPLSDIASVAGPCIVEGIRRLRCGKVDIQPGFDGEYGKVKVMDKNEIDLISGQLCFSNDKFFADTHTCSSEPSPPESVAGIKAPANAAEPAPDLTDESLPKNSEYGIQAVSVNFPYGLNKEQWEAVSSPGQAIAVIAGPGTGKTKTLVSRIAYLVEQCDIHPAQITAVTFTNKAAHEMRSRLEQHFGDKQTANAMTIGTFHSICLQILSQWKGKNNITIIDEYNALSIIEEIIKSMNLKISPRDALQGISLIKNGSPPAGDKKKSSIAAMVYDSYCSQLKGYGVMDYDDILLEVLQQFEHEKTGDVSGGSPDNFFSYLLVDEFQDINGVQYRLIKEWSRKSGKIFIIGDPDQSIYGFRGSDFRYFESFKEDFPDIRHIRLTRNYRSTPEIILSAQGVIAKKAAGECNGSLAATRKSGAKVRLIENNSEFSEALFVAKEINRMVGGIDMLDTQTPSAARRRRPAARQTRGFTDITVLYRTNRQAEILEQCFSKEGIPYVVVGRDEFLADKLVREAISFFKFLLNPGDITSLLVCLKAKSIYSADLNLKVLNGYVAGEKGITSLEKLLEEIQLPLHKPGVLRDFIEILRKYEPIINKEKPWKIIDSWISDNNLSGVRCMELLLHTSVMHNQMSSFIQNLVLGRESDVVRSGSKVYSPDAVALMTVHAAKGLEFPVTFICGVNDGLIPLKNSNPDFNMDEERRLFYVGMTRARDELILLTSRTPSPFVADISEEQLIIEKAFRQKQGSQYKQAGLFD
>AP018449.1|BBB93475.1|4688247_4688346_-|hypothetical-protein
MELEELIYEFRGTLTCDKNDKKSKKRWKLCSE
>AP018449.1|BBB93474.1|4687285_4688302_-|hypothetical-protein
MRQERQEEQEEMEALFGIGKAEQGESVAAEDGQADDYLYDKQLVNDDIQAIKALIEGDEAVTFSEGKIAEVAGDFTAPGERESVSAGVTPRLPLISAFENLLALQIKVKTAAILAAVILPLGIAFGTYYGIVAGTDAVGAMNDPGKQLYRMDIGSPSLAAASASPSPTDQLPPTASAASATEFRLAAGQAGFVQVGKTVESLREHYASLAIDQDHDNGRPYSVVKIYSAGAKVPSLEVNCFPADENGVQNKIAAIQVYDEQYKTIEGFGVNSLLGDLRRAGMVTSVQYADSSFYVLVKELGMKFELDLSASNLPAEWLNGGDLNSLPDNMKVRSILVF
>AP018449.1|BBB93473.1|4686611_4687289_+|germination-specific-N-acetylmuramoyl-L-alanine-amidase-precursor
MRIIYIAKRQFIFFLLPAMLLLGTLYAHNDVTHKLSDKVIIVDAGHGGIDPGANRPGVLEKEINLAVALMLKDILNQSGAKVVLSRQTDIDLSTECDNEKVRGRYHRDLTARVEMAEESDADLFISIHANAVANAQRRGAEVFYYAKSEPSKVLSNSIQTELGKITPAASAASTADYFVLRRNKIPAALVEIGYITNKEECALLQSPEYQQKLAAAIAKGIDNYY
>AP018449.1|BBB93472.1|4685201_4686266_-|cyclic-di-GMP-phosphodiesterase-response-regulator-RpfG
MAIKRYVISAVEPGMKLARPIFRDNGQVILYDGTVLTNFHIEKLRYFDVSYIDIIEHPDEYHPAQDVSAPPSDLSTIQGFQTLYDSTVNTLNQAFNSIRFLQEIPLAELRSMVGQAIMPMIDAVGVISHLQNVQHQDEYTFHHSLDVAVISGVLARWMGYTGQELEEIILSGLLHDVGKARIPLAILNKPEKLTTEEMDIMKLHTSKGYQMLNETKTLSPAVLCGVLQHHEKLDGSGYPLGVNEEKIHPYAKIIAVADIYCAMTSDRVYHKRRTPFKVVEHISQEMFNKLDPAVCTAFMNNVKDYFLGSVVKLSDGREAEVVYLGIYSSSRPVVRTKEGEFIDLERNKKIVIEG
>AP018449.1|BBB93471.1|4684182_4684995_-|NAD-synthetase
MPDKKLALLLQGLKELESAVVAFSGGVDSAFLAAAAKRALGDTAVAVTACSETLPDSERTESARIAEAIGIRHVFLPISELTSPEFVANTPERCYYCKKVRFSAIRRWADSQGIRWVLDGSNFDDASDYRPGMKAISELEGVQSPLLTFGFTKDEIRAVSREWELPTWNKLSAACLSSRVAYGLAVTPERLKQIEQAEAFIKTFFQGQIRVRHHGNLARIEVAPAGIPILTADGNSVQISRFLRSLGFQYVTLDLTGYRTGSMNEVLDFS
>AP018449.1|BBB93470.1|4683035_4684088_-|biotin-synthase
MSGIKTINDIISRAEHTHCLEKENIITLLSDEEGDELVFAAADRVGKKYVGNEVHLRGLIEFSNICKQNCLYCGLRRDNRNVKRYRLDPEAIIASAGQANSYGYRTVVLQSGEDDSFDLDTMVYIIHKIKELDMAITLSIGEKPREVYQKYREAGADRYLLRIETTDRELYERLDPGMSWDNRARCLCDLKELGFELGTGCLIGLPGQTIASLADDILFFKKMDADMIGVGPFIANKETPLGKEPNGTFELSTKVMAITRLLLPDINIPATTAMESLNPDGRVLALQRGANVVMPNVTEGEYRQLYQLYPGKICINDTPAHCHSCITGKIHSIGRTVSQGYGYRQKQAVS
>AP018449.1|BBB93469.1|4682031_4682787_-|lipoprotein-releasing-system-ATP-binding-protein-LolD
MIGKLLSWLVSTDLPQPRIGMAAIELSAVRKVYVTGAGEFEALKGVDLQVDAGEFVAVVGKSGSGKSTLINMIAGIDRPSDGDVWVAGTPVHTLTENQIAVWRGRTVGVVFQFFQLLPTLTSLENVMLPMDFCDVYNPVERPRRAFRLLEMVGVGDQADKLPANLSGGQQQRVAIARCLANDPPLLVADEPTGNLDARTASAVIDLFGELARSGKTILMVTHDQDLANRSSRIVTVSEGQISPVTADGGMA
>AP018449.1|BBB93479.1|4695048_4695321_-|hypothetical-protein
MLEKERGDFASLIERPEQEIDQAEWYQYIDTFIVTMGGEAYFDAVHFLQYGQSKQKFLSIPKRWDKFSDETEGGAILSIGACKRKYKGQG
>AP018449.1|BBB93480.1|4695467_4695752_-|hypothetical-protein
MAFRLGTWHVMESRECSLDRSYCVNLASCGTSSQARLGTRLNVVVGDLKEVVICEIGANVSKGTVLMTRLDLSLLCRLNRPHDSFKGRTGFVIA
>AP018449.1|BBB93481.1|4695779_4696649_-|putative-S-adenosyl-L-methionine-dependent-methyltransferase
MANKKSGQTAFNVAAIRLIEQYQSKDLRLFTDPVIKNLFNWPNRFLLGFKIIRDWLIRFSDKQTKGIYGSNICRTRYIDDSLQSAIENGIEQVVILGAGLDTRPYRILGRDQIKFFEVDMPSVQDYKKKKVESYLGSLPDNVVFIPIDFNSQTLDEVFAGKGLDFSKPVVFIWEGVTPYITEKAVGNTLQFISKNSPGSIVIFTYILKTVIEKKSDIDGVNDLVKYLEKYGVIWYFGLDPLNVAEFLKQFSLKLIEDVGASYYRENYLKPLGRRLDVSEIERIAYATVI
>AP018449.1|BBB93482.1|4697629_4698820_-|hypothetical-protein
MGSMFFISYSHEDDKDTKNIQQLDHVLKAYGLKTWIDQKNLPAGRMEQNIKKIIECERVEGYVLYVSQHSLRSHPVCEWELKPALKKRDHDPNFIMFFVLEGITFEEFKELSWRKFGVDLTQYYYQRIEEGNRLQTYHSVAQKLLDSKLQQVTEPLSEWVLNLYARGEDPKTSNKQPHLQIDLSYFFAERIPQQQEWEEIIIPAWQGIKRKIAGCPGRIHLQSNVLLPTGIAFGRVFHAATKYCLTFSDQEGWQTEGSVKDKAPLRQESHRGREDSDNIILEVGIAQDTRKATNDYVEKHHLDYRAWHSLKAEECSRNFIASPQHAYDTMTQIAEKIRKCSSEYPGNILIHLFYAGPLALAFMIGHCLNAVGPIQLYEFHKGLQQYEQGLLLKMND
>AP018449.1|BBB93483.1|4698830_4700090_-|RAMP-superfamily-protein
MSQTSTQVLHPADTQEMFQQFSSPDHLWYSMNYNQQADRQAREKEIDREEKKKNGDPDAVRYMFRKNLNHRDGLERITALGRTVDKQRLQALADLPEHYQVRILQATPMGGIIHGLGGAHVRENSLTIHPVYGFLYIPGSSLKGVVRRWFIEAFLGGKESHWDEKTEPWRQAATLGRLVFGTQASVGAVQFFDIFLIEGLQVKPDILTPHFSGYYAGKGTQAPEDTLNPVPNQFYIIQVQTADIVFTLRDTPAAAAMNLSADDLIGLLTDWVRTALQELGLGGKTSSGYGRFMDIQDVTLERFLPVKEKRLEEKKKEEQRKEQAEEQRRLSAMTSSERLIHDIRSLNSSTEEDIQRSKNDIFNQVLNAQNKEAAQCLKTYWESTNNWIIKRGSKKQNKQAVKVQKVRQLLGDWNDLLGN
>AP018449.1|BBB93484.1|4700086_4700539_-|CRISPR-associated-protein
MTRQNEAFCQIEEGRATFAFEQVKQAVEKLAGNAQSYKSYVRSLPSLIQVNGLGQALAFCYARKNKNKYIAYRDIYESIFNWLQRKFPDHFQQESELVEEAVKLRSEDYRMITMEVLALLNWMGRFAEGMIEDPLREDEEQANPSEGEAL
>AP018449.1|BBB93485.1|4700522_4701485_-|RAMP-superfamily-protein
MFTIARPFLLHAVTSVHAGSGSEIGTVDLPIQREKHTGYPKIESSSLKGALRHDLAVGIKNKPEEQEKFKWVFGSKPQEEEHDNESQASALSFIDARILLFPVRSLRGTFAWITCRNVLERFNREMTLLCSDKTSSVPQWPLEGVEPETTSSQAMLVGNRDKIVLEEYTMQTKQSGATQSLAERIAQSLGADVPLGIKERLVVLTDDQFADFVKMSTEINARIKVGDSGTTDRGLWYEENVPPETVFYSAVLIGQVRESNKKGADTGEDRMGTLTTDEDVRRYVGEHFPSVFQLGGSNTIGKGILRLIWLEGGAGHDKTE
>AP018449.1|BBB93486.1|4701497_4702670_-|CRISPR-associated-protein
MSKLSLVPADSFFFKGHLTTELGTPSHLVGLFPPRPNTVYGALRAAYIHRHSTFAEFRRGKGGPVKQWMGTPASYGAFRQRAILLAKNRDYLLPLPLDYNFYRLKNSDAGTWRALPLHLEPNSSASSAGVSWTLGLPDREKTAGKTASPGGRYLRLEDWKAGVLQQQSFSAILSLEDDIINDYAKTGIAIGRDSRTAERSYFYQMNMMNLKADCALVALSEPCPDFSEVPLVSLGGENRPWFLSQETNDWKLWSEEQLEEIKSQLQRTPIARIILLTPALWPNNLSFLLDLQTEGEIWQLTPDIEVEPITWATARPELYGGWDIVRHRPKPRQWMMPAGTVIYVKIRENDISPILALADGFTLFADQEECSGMEGFGFAVIAGIKESNQY
>AP018449.1|BBB93487.1|4702662_4704309_-|CRISPR-associated-protein
MPQQYAIFSIGPVQSFIAAARKLEDLWGGSYLLSYLIESTIANLYAAEASFELIYPRITAQEIKAKIGSQDPSLSIAHLPNRITFTLDTDDEGAVQLLKRAELHVRKEIGTLCAKAVELVFAEQKNIIDSLQDQIWQQTEAFLEVYWIVQSVGQTGGLQRQVVETRFQTLKNQRRLCPHQENGLACTLYPALDALCHEPLADKDRYGDLRRKLENTWEQRSPVFRPANDHDEGELEKARIRNREYLCAISLVKRMARDIFQRHYRCSNNIFSKYESVVEIGGQEAKYYAVLLMDGDNMGQRFADGSDVQELSRRLSRFSREAVPEIVSKHKGILIYAGGDDVLALFPVNQVLEAADALRHAFASEKEGLGTGATSSTGIAIGHKTSPLQQALNQARLLEATAKSYCSPSGNEKNALAIAVRTRSGEHLGPLVLPWQLYERPTTEYLQEFIAALEKELSPTFVYRFAQAFQPFLPNSYRSQAMPQLRREIIETEYRRLVKRAVRKRSEIEQTYELAGPSFHFYDILGLGAFIDLLKILTFFNRRRAEYE
>AP018449.1|BBB93488.1|4704308_4705253_-|hypothetical-protein
MLIEGAETSQYRAGSALQRKWYTVETLTPMAMHGANSRGDPQFRIPSLRGLLRYWWRAVQYETDPAKLLPKEEELFGGTQTEQSGKSLLRLVLHPPNFLLEEYPLLNHKPRTKDKSFTQVLKASQFLSIEASTYQFTRSDKWSHFQDALELALLLTGMGQRARRGFGAVQWQEHQFDSVESYGQRLCEVLSRLNVPIMSGITNGCLVKAVFNSGQLPPHPTLMAVWLGKPYEDNAAGVDCLLNDYGHASHLRSRASLGGIYPRFASPLWGSVRRIAGQLYPVISELQSAYSRKTPAVDYESDRNAFLQTLGVNI

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Crispr_ID: AP018449_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018449_7

4696838-4696928

TypeIII

Consensus_repeat	Method
ATCCCTTATAGGTAAGCTATAAAC	CRISPRCasFinder

1 spacers

cmr6gr7,cmr5gr11,cmr4gr7,cmr3gr5,cas10,cmr1gr7

The CRISPR arrays of AP018449_7

>merge|AP018449|7|4696838-4696928|CRISPRCasFinder
ATCCCTTATAGGTAAGCTATAAACTGACATAAACCGGGGGACTTCCTTTCCCATCGAAATTGTTTCAATCCCTTATAGGTAAGCTACAAAC

>AP018449|7|7|4696838-4696928|CRISPRCasFinder
ATCCCTTATAGGTAAGCTATAAAC	TGACATAAACCGGGGGACTTCCTTTCCCATCGAAATTGTTTCA
ATCCCTTATAGGTAAGCTACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
AP018449.1\|BBB93480.1\|4695467_4695752_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93475.1\|4688247_4688346_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93486.1\|4701497_4702670_-\|CRISPR-associated-protein	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|370625
AP018449.1\|BBB93482.1\|4697629_4698820_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380122
AP018449.1\|BBB93488.1\|4704308_4705253_-\|hypothetical-protein	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|187788
AP018449.1\|BBB93490.1\|4707967_4708837_-\|putative-S-adenosyl-L-methionine-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|272862
AP018449.1\|BBB93474.1\|4687285_4688302_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93485.1\|4700522_4701485_-\|RAMP-superfamily-protein	cmr4gr7	COG1336_cmr4gr7_CAS-III-C	gnl\|CDD\|224255
AP018449.1\|BBB93472.1\|4685201_4686266_-\|cyclic-di-GMP-phosphodiesterase-response-regulator-RpfG	unknown	unknown	gnl\|CDD\|225116
AP018449.1\|BBB93487.1\|4702662_4704309_-\|CRISPR-associated-protein	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
AP018449.1\|BBB93479.1\|4695048_4695321_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93478.1\|4692931_4694287_-\|multidrug-resistance-protein-NorM	unknown	unknown	gnl\|CDD\|240538
AP018449.1\|BBB93473.1\|4686611_4687289_+\|germination-specific-N-acetylmuramoyl-L-alanine-amidase-precursor	unknown	unknown	gnl\|CDD\|274337
AP018449.1\|BBB93483.1\|4698830_4700090_-\|RAMP-superfamily-protein	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	gnl\|CDD\|213662
AP018449.1\|BBB93481.1\|4695779_4696649_-\|putative-S-adenosyl-L-methionine-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|272862
AP018449.1\|BBB93489.1\|4705610_4706891_+\|transposase-IS116/IS110/IS902-family-protein	unknown	unknown	gnl\|CDD\|376564
AP018449.1\|BBB93484.1\|4700086_4700539_-\|CRISPR-associated-protein	cmr5gr11	pfam09701_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
AP018449.1\|BBB93491.1\|4710736_4710988_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93477.1\|4692318_4692864_+\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93476.1\|4688709_4692075_-\|ATP-dependent-DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|223288

Protein	Function_ID	Function_description	E-value
AP018449.1\|BBB93486.1\|4701497_4702670_-\|CRISPR-associated-protein	gnl\|CDD\|370625	pfam09700, Cas_Cmr3, CRISPR-associated protein (Cas_Cmr3). CRISPR is a term for Clustered Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family, found in at least ten different archaeal and bacterial species, is represented by TM1793 from Thermotoga maritima.	4.41336e-35
AP018449.1\|BBB93482.1\|4697629_4698820_-\|hypothetical-protein	gnl\|CDD\|380122	pfam18145, SAVED, SMODS-associated and fused to various effectors sensor domain. Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. The sensing of ligands by SAVED is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.	1.03129e-19
AP018449.1\|BBB93488.1\|4704308_4705253_-\|hypothetical-protein	gnl\|CDD\|187788	cd09657, Cmr1_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	2.42774e-12
AP018449.1\|BBB93490.1\|4707967_4708837_-\|putative-S-adenosyl-L-methionine-dependent-methyltransferase	gnl\|CDD\|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	1.46763e-57
AP018449.1\|BBB93485.1\|4700522_4701485_-\|RAMP-superfamily-protein	gnl\|CDD\|224255	COG1336, COG1336, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.09579e-64
AP018449.1\|BBB93472.1\|4685201_4686266_-\|cyclic-di-GMP-phosphodiesterase-response-regulator-RpfG	gnl\|CDD\|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	1.45675e-70
AP018449.1\|BBB93487.1\|4702662_4704309_-\|CRISPR-associated-protein	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	6.17976e-60
AP018449.1\|BBB93478.1\|4692931_4694287_-\|multidrug-resistance-protein-NorM	gnl\|CDD\|240538	cd13133, MATE_like_7, Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.	2.84162e-94
AP018449.1\|BBB93473.1\|4686611_4687289_+\|germination-specific-N-acetylmuramoyl-L-alanine-amidase-precursor	gnl\|CDD\|274337	TIGR02883, spore_cwlD, N-acetylmuramoyl-L-alanine amidase CwlD. Members of this protein family are the CwlD family of N-acetylmuramoyl-L-alanine amidase. This family has been called the germination-specific N-acetylmuramoyl-L-alanine amidase. CwlD is required, along with the putative deactylase PdaA, to make muramic delta-lactam, a novel peptidoglycan constituent found only in spores. CwlD mutants show a germination defect. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination].	1.27037e-69
AP018449.1\|BBB93483.1\|4698830_4700090_-\|RAMP-superfamily-protein	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	4.23676e-31
AP018449.1\|BBB93481.1\|4695779_4696649_-\|putative-S-adenosyl-L-methionine-dependent-methyltransferase	gnl\|CDD\|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	7.73285e-57
AP018449.1\|BBB93489.1\|4705610_4706891_+\|transposase-IS116/IS110/IS902-family-protein	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	4.7896e-29
AP018449.1\|BBB93484.1\|4700086_4700539_-\|CRISPR-associated-protein	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	9.33494e-33
AP018449.1\|BBB93476.1\|4688709_4692075_-\|ATP-dependent-DNA-helicase-PcrA	gnl\|CDD\|223288	COG0210, UvrD, Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].	5.02744e-129

>AP018449.1|BBB93481.1|4695779_4696649_-|putative-S-adenosyl-L-methionine-dependent-methyltransferase
MANKKSGQTAFNVAAIRLIEQYQSKDLRLFTDPVIKNLFNWPNRFLLGFKIIRDWLIRFSDKQTKGIYGSNICRTRYIDDSLQSAIENGIEQVVILGAGLDTRPYRILGRDQIKFFEVDMPSVQDYKKKKVESYLGSLPDNVVFIPIDFNSQTLDEVFAGKGLDFSKPVVFIWEGVTPYITEKAVGNTLQFISKNSPGSIVIFTYILKTVIEKKSDIDGVNDLVKYLEKYGVIWYFGLDPLNVAEFLKQFSLKLIEDVGASYYRENYLKPLGRRLDVSEIERIAYATVI
>AP018449.1|BBB93480.1|4695467_4695752_-|hypothetical-protein
MAFRLGTWHVMESRECSLDRSYCVNLASCGTSSQARLGTRLNVVVGDLKEVVICEIGANVSKGTVLMTRLDLSLLCRLNRPHDSFKGRTGFVIA
>AP018449.1|BBB93479.1|4695048_4695321_-|hypothetical-protein
MLEKERGDFASLIERPEQEIDQAEWYQYIDTFIVTMGGEAYFDAVHFLQYGQSKQKFLSIPKRWDKFSDETEGGAILSIGACKRKYKGQG
>AP018449.1|BBB93478.1|4692931_4694287_-|multidrug-resistance-protein-NorM
MDRHIVSYRHIVQIAYPVTLSMLSMNAMIFVDRMFVSQYNLTQFAAMIPAGLFATSIASIFGGIVGYSSVLVSQYFGARRYNDCSASTWQAVYLSALFVVLLIVSSVGLENIFQVLGHDESLIHFEKEYFYLIISANCFQLFTTALSGLYYGIGDTRTTMHIEIFINVANMVLAWLLVLGKCGFPAMGMFGAGLATNISSAIGLAVYLLRLNQRSFKSRFQFFINFDFNKFLLHKIVKFGLFSGIQSFTITGYFSIFLLIIGMRGEFDLTCANIAVALQAASILPVYGITTAVGILAGQERGADRPDNLTIILKKGILISSCYVILIVIFFNLLPEFLISIFNSEHDKERLVLINNATIPLVRLTSICVALEMVFSTIGSALQAVGDTRFMMVTYTVIPFIFYVIMPYIICVRGSLSLEVLWIMLIGYRIIMLLVVTRRFVGGKWKAINVI
>AP018449.1|BBB93477.1|4692318_4692864_+|hypothetical-protein
MSNQVLLWLILILPLLTLFFMPKENIKRWTPVALFSALTSVIAVELGENLGWFIYEEAAYPLRTPSYIIFGLNIVVTIWSFHFLYGRFWRYIVIDTVLNFGFIYLFHVYFLGGRGLFHEVGLTPFLNTLIVTFDGVLAYGYQIWQEEIFVRSETKSADYASNLQPAAAKPLPENQDNEKSE
>AP018449.1|BBB93476.1|4688709_4692075_-|ATP-dependent-DNA-helicase-PcrA
MFIADFHIHSRYSRATSKDCVPEMLELWARRKGINVIGTGDFTHPAWREELKEKLVPAGEGLYILKNDFRKEDKIAGADFKPQFIVSGEISSIYKKNGRVRKVHNLILLPSLEYAELISHKLEAIGNLRSDGRPILGLDSRDLLEIVLDTCPEAIFIPAHIWTPHFSLYGAYSGFDDITECFGDLTGYIYALETGLSSDPPMNWRLSALDNFTLVSNSDAHSPANLGREANIFNTGLSYPCMLQALKNRNTKEFYGTIEFFPEEGKYHYDGHRACKVCWKPAETKAAGGICPVCGGRLTVGVLHRVEALADREEGFIPPVVKHFESLVPLNQVIASVLGSTVTSMKVKKKYDDLLRGLGPELFILREAPLSDIASVAGPCIVEGIRRLRCGKVDIQPGFDGEYGKVKVMDKNEIDLISGQLCFSNDKFFADTHTCSSEPSPPESVAGIKAPANAAEPAPDLTDESLPKNSEYGIQAVSVNFPYGLNKEQWEAVSSPGQAIAVIAGPGTGKTKTLVSRIAYLVEQCDIHPAQITAVTFTNKAAHEMRSRLEQHFGDKQTANAMTIGTFHSICLQILSQWKGKNNITIIDEYNALSIIEEIIKSMNLKISPRDALQGISLIKNGSPPAGDKKKSSIAAMVYDSYCSQLKGYGVMDYDDILLEVLQQFEHEKTGDVSGGSPDNFFSYLLVDEFQDINGVQYRLIKEWSRKSGKIFIIGDPDQSIYGFRGSDFRYFESFKEDFPDIRHIRLTRNYRSTPEIILSAQGVIAKKAAGECNGSLAATRKSGAKVRLIENNSEFSEALFVAKEINRMVGGIDMLDTQTPSAARRRRPAARQTRGFTDITVLYRTNRQAEILEQCFSKEGIPYVVVGRDEFLADKLVREAISFFKFLLNPGDITSLLVCLKAKSIYSADLNLKVLNGYVAGEKGITSLEKLLEEIQLPLHKPGVLRDFIEILRKYEPIINKEKPWKIIDSWISDNNLSGVRCMELLLHTSVMHNQMSSFIQNLVLGRESDVVRSGSKVYSPDAVALMTVHAAKGLEFPVTFICGVNDGLIPLKNSNPDFNMDEERRLFYVGMTRARDELILLTSRTPSPFVADISEEQLIIEKAFRQKQGSQYKQAGLFD
>AP018449.1|BBB93475.1|4688247_4688346_-|hypothetical-protein
MELEELIYEFRGTLTCDKNDKKSKKRWKLCSE
>AP018449.1|BBB93474.1|4687285_4688302_-|hypothetical-protein
MRQERQEEQEEMEALFGIGKAEQGESVAAEDGQADDYLYDKQLVNDDIQAIKALIEGDEAVTFSEGKIAEVAGDFTAPGERESVSAGVTPRLPLISAFENLLALQIKVKTAAILAAVILPLGIAFGTYYGIVAGTDAVGAMNDPGKQLYRMDIGSPSLAAASASPSPTDQLPPTASAASATEFRLAAGQAGFVQVGKTVESLREHYASLAIDQDHDNGRPYSVVKIYSAGAKVPSLEVNCFPADENGVQNKIAAIQVYDEQYKTIEGFGVNSLLGDLRRAGMVTSVQYADSSFYVLVKELGMKFELDLSASNLPAEWLNGGDLNSLPDNMKVRSILVF
>AP018449.1|BBB93473.1|4686611_4687289_+|germination-specific-N-acetylmuramoyl-L-alanine-amidase-precursor
MRIIYIAKRQFIFFLLPAMLLLGTLYAHNDVTHKLSDKVIIVDAGHGGIDPGANRPGVLEKEINLAVALMLKDILNQSGAKVVLSRQTDIDLSTECDNEKVRGRYHRDLTARVEMAEESDADLFISIHANAVANAQRRGAEVFYYAKSEPSKVLSNSIQTELGKITPAASAASTADYFVLRRNKIPAALVEIGYITNKEECALLQSPEYQQKLAAAIAKGIDNYY
>AP018449.1|BBB93472.1|4685201_4686266_-|cyclic-di-GMP-phosphodiesterase-response-regulator-RpfG
MAIKRYVISAVEPGMKLARPIFRDNGQVILYDGTVLTNFHIEKLRYFDVSYIDIIEHPDEYHPAQDVSAPPSDLSTIQGFQTLYDSTVNTLNQAFNSIRFLQEIPLAELRSMVGQAIMPMIDAVGVISHLQNVQHQDEYTFHHSLDVAVISGVLARWMGYTGQELEEIILSGLLHDVGKARIPLAILNKPEKLTTEEMDIMKLHTSKGYQMLNETKTLSPAVLCGVLQHHEKLDGSGYPLGVNEEKIHPYAKIIAVADIYCAMTSDRVYHKRRTPFKVVEHISQEMFNKLDPAVCTAFMNNVKDYFLGSVVKLSDGREAEVVYLGIYSSSRPVVRTKEGEFIDLERNKKIVIEG
>AP018449.1|BBB93482.1|4697629_4698820_-|hypothetical-protein
MGSMFFISYSHEDDKDTKNIQQLDHVLKAYGLKTWIDQKNLPAGRMEQNIKKIIECERVEGYVLYVSQHSLRSHPVCEWELKPALKKRDHDPNFIMFFVLEGITFEEFKELSWRKFGVDLTQYYYQRIEEGNRLQTYHSVAQKLLDSKLQQVTEPLSEWVLNLYARGEDPKTSNKQPHLQIDLSYFFAERIPQQQEWEEIIIPAWQGIKRKIAGCPGRIHLQSNVLLPTGIAFGRVFHAATKYCLTFSDQEGWQTEGSVKDKAPLRQESHRGREDSDNIILEVGIAQDTRKATNDYVEKHHLDYRAWHSLKAEECSRNFIASPQHAYDTMTQIAEKIRKCSSEYPGNILIHLFYAGPLALAFMIGHCLNAVGPIQLYEFHKGLQQYEQGLLLKMND
>AP018449.1|BBB93483.1|4698830_4700090_-|RAMP-superfamily-protein
MSQTSTQVLHPADTQEMFQQFSSPDHLWYSMNYNQQADRQAREKEIDREEKKKNGDPDAVRYMFRKNLNHRDGLERITALGRTVDKQRLQALADLPEHYQVRILQATPMGGIIHGLGGAHVRENSLTIHPVYGFLYIPGSSLKGVVRRWFIEAFLGGKESHWDEKTEPWRQAATLGRLVFGTQASVGAVQFFDIFLIEGLQVKPDILTPHFSGYYAGKGTQAPEDTLNPVPNQFYIIQVQTADIVFTLRDTPAAAAMNLSADDLIGLLTDWVRTALQELGLGGKTSSGYGRFMDIQDVTLERFLPVKEKRLEEKKKEEQRKEQAEEQRRLSAMTSSERLIHDIRSLNSSTEEDIQRSKNDIFNQVLNAQNKEAAQCLKTYWESTNNWIIKRGSKKQNKQAVKVQKVRQLLGDWNDLLGN
>AP018449.1|BBB93484.1|4700086_4700539_-|CRISPR-associated-protein
MTRQNEAFCQIEEGRATFAFEQVKQAVEKLAGNAQSYKSYVRSLPSLIQVNGLGQALAFCYARKNKNKYIAYRDIYESIFNWLQRKFPDHFQQESELVEEAVKLRSEDYRMITMEVLALLNWMGRFAEGMIEDPLREDEEQANPSEGEAL
>AP018449.1|BBB93485.1|4700522_4701485_-|RAMP-superfamily-protein
MFTIARPFLLHAVTSVHAGSGSEIGTVDLPIQREKHTGYPKIESSSLKGALRHDLAVGIKNKPEEQEKFKWVFGSKPQEEEHDNESQASALSFIDARILLFPVRSLRGTFAWITCRNVLERFNREMTLLCSDKTSSVPQWPLEGVEPETTSSQAMLVGNRDKIVLEEYTMQTKQSGATQSLAERIAQSLGADVPLGIKERLVVLTDDQFADFVKMSTEINARIKVGDSGTTDRGLWYEENVPPETVFYSAVLIGQVRESNKKGADTGEDRMGTLTTDEDVRRYVGEHFPSVFQLGGSNTIGKGILRLIWLEGGAGHDKTE
>AP018449.1|BBB93486.1|4701497_4702670_-|CRISPR-associated-protein
MSKLSLVPADSFFFKGHLTTELGTPSHLVGLFPPRPNTVYGALRAAYIHRHSTFAEFRRGKGGPVKQWMGTPASYGAFRQRAILLAKNRDYLLPLPLDYNFYRLKNSDAGTWRALPLHLEPNSSASSAGVSWTLGLPDREKTAGKTASPGGRYLRLEDWKAGVLQQQSFSAILSLEDDIINDYAKTGIAIGRDSRTAERSYFYQMNMMNLKADCALVALSEPCPDFSEVPLVSLGGENRPWFLSQETNDWKLWSEEQLEEIKSQLQRTPIARIILLTPALWPNNLSFLLDLQTEGEIWQLTPDIEVEPITWATARPELYGGWDIVRHRPKPRQWMMPAGTVIYVKIRENDISPILALADGFTLFADQEECSGMEGFGFAVIAGIKESNQY
>AP018449.1|BBB93487.1|4702662_4704309_-|CRISPR-associated-protein
MPQQYAIFSIGPVQSFIAAARKLEDLWGGSYLLSYLIESTIANLYAAEASFELIYPRITAQEIKAKIGSQDPSLSIAHLPNRITFTLDTDDEGAVQLLKRAELHVRKEIGTLCAKAVELVFAEQKNIIDSLQDQIWQQTEAFLEVYWIVQSVGQTGGLQRQVVETRFQTLKNQRRLCPHQENGLACTLYPALDALCHEPLADKDRYGDLRRKLENTWEQRSPVFRPANDHDEGELEKARIRNREYLCAISLVKRMARDIFQRHYRCSNNIFSKYESVVEIGGQEAKYYAVLLMDGDNMGQRFADGSDVQELSRRLSRFSREAVPEIVSKHKGILIYAGGDDVLALFPVNQVLEAADALRHAFASEKEGLGTGATSSTGIAIGHKTSPLQQALNQARLLEATAKSYCSPSGNEKNALAIAVRTRSGEHLGPLVLPWQLYERPTTEYLQEFIAALEKELSPTFVYRFAQAFQPFLPNSYRSQAMPQLRREIIETEYRRLVKRAVRKRSEIEQTYELAGPSFHFYDILGLGAFIDLLKILTFFNRRRAEYE
>AP018449.1|BBB93488.1|4704308_4705253_-|hypothetical-protein
MLIEGAETSQYRAGSALQRKWYTVETLTPMAMHGANSRGDPQFRIPSLRGLLRYWWRAVQYETDPAKLLPKEEELFGGTQTEQSGKSLLRLVLHPPNFLLEEYPLLNHKPRTKDKSFTQVLKASQFLSIEASTYQFTRSDKWSHFQDALELALLLTGMGQRARRGFGAVQWQEHQFDSVESYGQRLCEVLSRLNVPIMSGITNGCLVKAVFNSGQLPPHPTLMAVWLGKPYEDNAAGVDCLLNDYGHASHLRSRASLGGIYPRFASPLWGSVRRIAGQLYPVISELQSAYSRKTPAVDYESDRNAFLQTLGVNI
>AP018449.1|BBB93489.1|4705610_4706891_+|transposase-IS116/IS110/IS902-family-protein
MKKADLLSTLFVGIDVSSRENVVCAIDYEAQKLLRFSVPNNHPGAIEMAEKLHAFLYGNRDINKLMLALESTSFYGIHIANYLSSCELLMPFHTHVYCLNPKMIANYKKSYIDLGKNDAVDAFVIADFARVGRITTAPWRGSQFLALQRLTRHRLHIAASLTREKTYMLSNIFLKFSQLSMLHEDQQPFSDHYGATASSVLTDFLSTEDIANMPLQALIDHIGQKGKNRFVNPGHTASLLQQAARNSYRLDKCLYEPLTLSIASSFNLISAYESEIKAINKAIEKTLKGLDPNAYHSLLSIPGIGPVYAAGIIAEIGSIDAFNSHSAFAKYAGLVWRENQSGNFRADDTVLSKAGNSYLRYYLIEAASHVKNHIPEYAAFYHKKYDEVKTHQHKRALALTARKFIRLIFGLLVNHQLYSKSRVSQI
>AP018449.1|BBB93490.1|4707967_4708837_-|putative-S-adenosyl-L-methionine-dependent-methyltransferase
MANKKSGQTAFNVAAIRLIEQYQPKDLRLFTDPVIKNLFNWPNRFLLGFKIIRDWLIRFSDKQTKGIYGSNICRTRYIDDSLQSAIENGIEQVVILGAGLDTRPYRILGRDQIKFFEVDMPSVQDYKKKKVESYLGSLPDNVVFIPIDFNSQTLDEVFAGKGLDFSKPVVFIWEGVTPYITEKAVGNTLQFISKNSPGSIVIFTYILKTVIEKKSDINGVNDLVKYLEKYGVIWYFGLDPLNVAEFLKQFSLKLIEDVGASYYRENYLKPLGRRLDVSEIERIAYAMVI
>AP018449.1|BBB93491.1|4710736_4710988_-|hypothetical-protein
MGGEAYFDAVHFLQYGQSKQKFLSIPKRWDKLSDETEGGAILSIGACKEDIRAKGNQWDKKSRVSIVLRKAKIVFILFVVDLQ

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Crispr_ID: AP018449_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018449_8

4709020-4710576

TypeIII

Consensus_repeat	Method
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CRISPRCasFinder
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CRT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	PILER-CR

23 spacers

cmr1gr7,cas10,cmr3gr5,cmr4gr7,cmr5gr11,cmr6gr7,csm3gr7

The CRISPR arrays of AP018449_8

>merge|AP018449|8|4709020-4710576|CRISPRCasFinder,CRT,PILER-CR
CACATGATCCCTTATAGGTAAGCTATAAACTGACATAAACCGGGGGACTTCCTTTCCCATCGAAATTGTTTCAATCCCTTATAGGTAAGCTATAAACAAGAGTACTGCATTCTAAACAGTTTACAACCAATGTCGTTTCAATCCCTTATAGGTAAACTATAAACGAAGAATGTAGCAAACTTGAAACTGCAAATGCAAAGTTTCAATCCCTTATAGGTAAGCTATAAACCAGACATATTGGAGGTATTCCTTATTTGGATACCGCTGTTTCAATCCCTTATAGGTAAGCTATAAACAGTCCAGTGTTTACGGGAACTCAGACGGCGATATGAGTTTCAATCCCTTATAGGTAAGCTATAAACTGTTCAGGGTTTCGATTGGTCCACCATCCTTACCGGGTTTCAATCCCTTATAGGTAAGCTATAAACGACTGCCGGAAAGAAAAAAGAAGACACCTATCAGGAGTTTCAATCCCTTATAGGTAAGCTATAAACACGGGAGTCCCATCGCCGCGTCTGCTGACCTGGCACGGTTTCAATCCCTTATAGGTAAGCTATAAACCGCGTCCTCCATATCGAAGAATACCGGCATTTCAAAGTTTCAATCCCTTATAGGTAAGCTATAAACCTTTTGACGTACTTTGTTTTTTGAATCCGCTCCCGGAGTTTCAATCCCTTATAGGTAAGCTATAAACTTTTCTTCCTGCGTAGACACTGGCGAAGTCATGACGGCGTTTCAATCCCTTATAGGTAAGCTATAAACAAAGAAAGAGATCCGGATCTTGTCTCAGAGAAACTTGTTTCAATCCCTTATAGGTAAGCTATAAACCGGCGCTGCCGTCCACAATGGCCCACATGATTTCACGTTTCAATCCCTTATAGGTAAGCTATAAACCGGCAATTTCACCACTGGCTACACCGCCGATTTCCCCGTTTCAATCCCTTATAGGTAAGCTATAAACACATCCGTTTCTTCCGGAATTGTGGATGTCGGAGGGAGTTTCAATCCCTTATAGGTAAGCTATAAACGATATTCTCCTCACCACCGCTTCCACGCCAAATAGGTTTCAATCCCTTATAGGTAAGCTATAAACTGTACTCTTGACGCGCCGTCTTGCTTTCAATGAGGAGTTTCAATCCCTTATAGGTAAGCTATAAACTGTTGGGAATCGGATCAGGCCGAAGTATCCGTTTCTGTTTCAATCCCTTATAGGTAAGCTATAAACTCCAGAGCCGGACAATCCATTGCAGGCTTTTGGAAGTTTCAATCCCTTATAGGTAAGCTATAAACCAAGCCGAAATAATTGCAGCCATGAAACACCGCAAGCGTTTCAATCCCTTATAGGTAAGCTATAAACCTTTTCTCTTGCAAGGAATTCTAAATCTTCGATGCAGTTTCAATCCCTTATAGGTAAGCTATAAACTTTGAATGAACTTGTACTATCCGGACCGGTTGATTAGTTTCAATCCCTTATAGGTAAGCTATAAACGGTTGACAACATACCCAAAGTCAAAAACGTTCCGGCAAGTTTCAATCCCTTATAGGTAAGCTATAAAC

>AP018449|8|8|4709020-4710576|CRISPRCasFinder
CACATGATCCCTTATAGGTAAGCTATAAAC	TGACATAAACCGGGGGACTTCCTTTCCCATCGAAATT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	AAGAGTACTGCATTCTAAACAGTTTACAACCAATGTC
GTTTCAATCCCTTATAGGTAAACTATAAAC	GAAGAATGTAGCAAACTTGAAACTGCAAATGCAAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CAGACATATTGGAGGTATTCCTTATTTGGATACCGCT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	AGTCCAGTGTTTACGGGAACTCAGACGGCGATATGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TGTTCAGGGTTTCGATTGGTCCACCATCCTTACCGG
GTTTCAATCCCTTATAGGTAAGCTATAAAC	GACTGCCGGAAAGAAAAAAGAAGACACCTATCAGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	ACGGGAGTCCCATCGCCGCGTCTGCTGACCTGGCACG
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CGCGTCCTCCATATCGAAGAATACCGGCATTTCAAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CTTTTGACGTACTTTGTTTTTTGAATCCGCTCCCGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TTTTCTTCCTGCGTAGACACTGGCGAAGTCATGACGGC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	AAAGAAAGAGATCCGGATCTTGTCTCAGAGAAACTT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CGGCGCTGCCGTCCACAATGGCCCACATGATTTCAC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CGGCAATTTCACCACTGGCTACACCGCCGATTTCCCC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	ACATCCGTTTCTTCCGGAATTGTGGATGTCGGAGGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	GATATTCTCCTCACCACCGCTTCCACGCCAAATAG
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TGTACTCTTGACGCGCCGTCTTGCTTTCAATGAGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TGTTGGGAATCGGATCAGGCCGAAGTATCCGTTTCT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TCCAGAGCCGGACAATCCATTGCAGGCTTTTGGAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CAAGCCGAAATAATTGCAGCCATGAAACACCGCAAGC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CTTTTCTCTTGCAAGGAATTCTAAATCTTCGATGCA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TTTGAATGAACTTGTACTATCCGGACCGGTTGATTA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	GGTTGACAACATACCCAAAGTCAAAAACGTTCCGGCAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC

>AP018449|8|6|4709020-4710576|CRT
CACATGATCCCTTATAGGTAAGCTATAAAC	TGACATAAACCGGGGGACTTCCTTTCCCATCGAAATT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	AAGAGTACTGCATTCTAAACAGTTTACAACCAATGTC
GTTTCAATCCCTTATAGGTAAACTATAAAC	GAAGAATGTAGCAAACTTGAAACTGCAAATGCAAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CAGACATATTGGAGGTATTCCTTATTTGGATACCGCT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	AGTCCAGTGTTTACGGGAACTCAGACGGCGATATGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TGTTCAGGGTTTCGATTGGTCCACCATCCTTACCGG
GTTTCAATCCCTTATAGGTAAGCTATAAAC	GACTGCCGGAAAGAAAAAAGAAGACACCTATCAGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	ACGGGAGTCCCATCGCCGCGTCTGCTGACCTGGCACG
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CGCGTCCTCCATATCGAAGAATACCGGCATTTCAAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CTTTTGACGTACTTTGTTTTTTGAATCCGCTCCCGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TTTTCTTCCTGCGTAGACACTGGCGAAGTCATGACGGC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	AAAGAAAGAGATCCGGATCTTGTCTCAGAGAAACTT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CGGCGCTGCCGTCCACAATGGCCCACATGATTTCAC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CGGCAATTTCACCACTGGCTACACCGCCGATTTCCCC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	ACATCCGTTTCTTCCGGAATTGTGGATGTCGGAGGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	GATATTCTCCTCACCACCGCTTCCACGCCAAATAG
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TGTACTCTTGACGCGCCGTCTTGCTTTCAATGAGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TGTTGGGAATCGGATCAGGCCGAAGTATCCGTTTCT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TCCAGAGCCGGACAATCCATTGCAGGCTTTTGGAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CAAGCCGAAATAATTGCAGCCATGAAACACCGCAAGC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CTTTTCTCTTGCAAGGAATTCTAAATCTTCGATGCA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TTTGAATGAACTTGTACTATCCGGACCGGTTGATTA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	GGTTGACAACATACCCAAAGTCAAAAACGTTCCGGCAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC

>AP018449|8|6|4709087-4710576|PILER-CR
GTTTCAATCCCTTATAGGTAAGCTATAAAC	AAGAGTACTGCATTCTAAACAGTTTACAACCAATGTC
GTTTCAATCCCTTATAGGTAAACTATAAAC	GAAGAATGTAGCAAACTTGAAACTGCAAATGCAAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CAGACATATTGGAGGTATTCCTTATTTGGATACCGCT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	AGTCCAGTGTTTACGGGAACTCAGACGGCGATATGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TGTTCAGGGTTTCGATTGGTCCACCATCCTTACCGG
GTTTCAATCCCTTATAGGTAAGCTATAAAC	GACTGCCGGAAAGAAAAAAGAAGACACCTATCAGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	ACGGGAGTCCCATCGCCGCGTCTGCTGACCTGGCACG
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CGCGTCCTCCATATCGAAGAATACCGGCATTTCAAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CTTTTGACGTACTTTGTTTTTTGAATCCGCTCCCGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TTTTCTTCCTGCGTAGACACTGGCGAAGTCATGACGGC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	AAAGAAAGAGATCCGGATCTTGTCTCAGAGAAACTT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CGGCGCTGCCGTCCACAATGGCCCACATGATTTCAC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CGGCAATTTCACCACTGGCTACACCGCCGATTTCCCC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	ACATCCGTTTCTTCCGGAATTGTGGATGTCGGAGGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	GATATTCTCCTCACCACCGCTTCCACGCCAAATAG
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TGTACTCTTGACGCGCCGTCTTGCTTTCAATGAGGA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TGTTGGGAATCGGATCAGGCCGAAGTATCCGTTTCT
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TCCAGAGCCGGACAATCCATTGCAGGCTTTTGGAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CAAGCCGAAATAATTGCAGCCATGAAACACCGCAAGC
GTTTCAATCCCTTATAGGTAAGCTATAAAC	CTTTTCTCTTGCAAGGAATTCTAAATCTTCGATGCA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	TTTGAATGAACTTGTACTATCCGGACCGGTTGATTA
GTTTCAATCCCTTATAGGTAAGCTATAAAC	GGTTGACAACATACCCAAAGTCAAAAACGTTCCGGCAA
GTTTCAATCCCTTATAGGTAAGCTATAAAC

Protein	Signature genes	Signature genes Name	Protein_function
AP018449.1\|BBB93494.1\|4712872_4712986_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93496.1\|4713468_4714479_-\|NADH-oxidase	unknown	unknown	gnl\|CDD\|224814
AP018449.1\|BBB93493.1\|4711556_4712831_-\|cystathionine-beta-lyase-MetC	unknown	unknown	gnl\|CDD\|223699
AP018449.1\|BBB93486.1\|4701497_4702670_-\|CRISPR-associated-protein	cmr3gr5	pfam09700_cmr3gr5_CAS-III-B	gnl\|CDD\|370625
AP018449.1\|BBB93482.1\|4697629_4698820_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380122
AP018449.1\|BBB93488.1\|4704308_4705253_-\|hypothetical-protein	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl\|CDD\|187788
AP018449.1\|BBB93481.1\|4695779_4696649_-\|putative-S-adenosyl-L-methionine-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|272862
AP018449.1\|BBB93490.1\|4707967_4708837_-\|putative-S-adenosyl-L-methionine-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|272862
AP018449.1\|BBB93499.1\|4715904_4717092_+\|purine-efflux-pump-PbuE	unknown	unknown	gnl\|CDD\|340882
AP018449.1\|BBB93487.1\|4702662_4704309_-\|CRISPR-associated-protein	cas10	cd09679_cas10_CAS-III	gnl\|CDD\|187810
AP018449.1\|BBB93500.1\|4717659_4718313_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|176554
AP018449.1\|BBB93491.1\|4710736_4710988_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93483.1\|4698830_4700090_-\|RAMP-superfamily-protein	cmr6gr7	cd09661_cmr6gr7_CAS-III-B	gnl\|CDD\|213662
AP018449.1\|BBB93497.1\|4714610_4714988_+\|HTH-type-transcriptional-activator-HxlR	unknown	unknown	gnl\|CDD\|224647
AP018449.1\|BBB93498.1\|4715119_4715701_-\|HTH-type-transcriptional-repressor-Bm3R1	unknown	unknown	gnl\|CDD\|379883
AP018449.1\|BBB93485.1\|4700522_4701485_-\|RAMP-superfamily-protein	cmr4gr7	COG1336_cmr4gr7_CAS-III-C	gnl\|CDD\|224255
AP018449.1\|BBB93489.1\|4705610_4706891_+\|transposase-IS116/IS110/IS902-family-protein	unknown	unknown	gnl\|CDD\|376564
AP018449.1\|BBB93484.1\|4700086_4700539_-\|CRISPR-associated-protein	cmr5gr11	pfam09701_cmr5gr11_CAS-III-B	gnl\|CDD\|378242
AP018449.1\|BBB93495.1\|4712982_4713438_-\|glyoxalase-like-domain-protein	unknown	unknown	gnl\|CDD\|366361
AP018449.1\|BBB93492.1\|4711070_4711307_-\|hypothetical-protein	csm3gr7	cls000253_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|274902

Protein	Function_ID	Function_description	E-value
AP018449.1\|BBB93496.1\|4713468_4714479_-\|NADH-oxidase	gnl\|CDD\|224814	COG1902, NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion].	1.61907e-79
AP018449.1\|BBB93493.1\|4711556_4712831_-\|cystathionine-beta-lyase-MetC	gnl\|CDD\|223699	COG0626, MetC, Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism].	5.74733e-71
AP018449.1\|BBB93486.1\|4701497_4702670_-\|CRISPR-associated-protein	gnl\|CDD\|370625	pfam09700, Cas_Cmr3, CRISPR-associated protein (Cas_Cmr3). CRISPR is a term for Clustered Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family, found in at least ten different archaeal and bacterial species, is represented by TM1793 from Thermotoga maritima.	4.41336e-35
AP018449.1\|BBB93482.1\|4697629_4698820_-\|hypothetical-protein	gnl\|CDD\|380122	pfam18145, SAVED, SMODS-associated and fused to various effectors sensor domain. Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. The sensing of ligands by SAVED is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.	1.03129e-19
AP018449.1\|BBB93488.1\|4704308_4705253_-\|hypothetical-protein	gnl\|CDD\|187788	cd09657, Cmr1_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	2.42774e-12
AP018449.1\|BBB93481.1\|4695779_4696649_-\|putative-S-adenosyl-L-methionine-dependent-methyltransferase	gnl\|CDD\|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	7.73285e-57
AP018449.1\|BBB93490.1\|4707967_4708837_-\|putative-S-adenosyl-L-methionine-dependent-methyltransferase	gnl\|CDD\|272862	TIGR00027, Hypothetical_protein_Rv0893c/MT0917/Mb0917c., methyltransferase, TIGR00027 family. This model represents a set of probable methyltransferases, about 300 amino acids long, with essentially full length homology. Members share an N-terminal region described by Pfam model pfam02409. Included are a paralogous family of 12 proteins in Mycobacterium tuberculosis, plus close homologs in related species, a family of 8 in the archaeon Methanosarcina acetivorans, and small numbers of members in other species, including plants. [Unknown function, Enzymes of unknown specificity].	1.46763e-57
AP018449.1\|BBB93487.1\|4702662_4704309_-\|CRISPR-associated-protein	gnl\|CDD\|187810	cd09679, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; MTH326-like has inactivated polymerase catalytic domain; alr1562 and slr7011 - predicted only on the basis of size, presence of HD domain, and location with RAMPs in one operon; signature gene for type III; also known as Crm2 family.	6.17976e-60
AP018449.1\|BBB93500.1\|4717659_4718313_-\|hypothetical-protein	gnl\|CDD\|176554	cd08613, GDPD_GDE4_like_1, Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4. This subfamily corresponds to the glycerophosphodiester phosphodiesterase domain (GDPD) present in uncharacterized bacterial homologs of mammalian GDE4, a transmembrane protein whose cellular function has not been elucidated yet.	3.75734e-75
AP018449.1\|BBB93499.1\|4715904_4717092_+\|purine-efflux-pump-PbuE	gnl\|CDD\|340882	cd17324, MFS_NepI_like, Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily. This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	5.00144e-66
AP018449.1\|BBB93483.1\|4698830_4700090_-\|RAMP-superfamily-protein	gnl\|CDD\|213662	TIGR01898, repair_system, CRISPR type III-B/RAMP module RAMP protein Cmr6. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This family, represented by TM1791 of Thermotoga maritima, is designated Cmr6 [sic], for CRISPR/Cas Ramp Module protein 6. This family is both closely related to and frequently encoded next to the TM1792 family of Cas proteins described by TIGR01867. The two proteins are fused in an example from Methanopyrus kandleri.	4.23676e-31
AP018449.1\|BBB93497.1\|4714610_4714988_+\|HTH-type-transcriptional-activator-HxlR	gnl\|CDD\|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	3.52635e-32
AP018449.1\|BBB93498.1\|4715119_4715701_-\|HTH-type-transcriptional-repressor-Bm3R1	gnl\|CDD\|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	3.20015e-31
AP018449.1\|BBB93485.1\|4700522_4701485_-\|RAMP-superfamily-protein	gnl\|CDD\|224255	COG1336, COG1336, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.09579e-64
AP018449.1\|BBB93489.1\|4705610_4706891_+\|transposase-IS116/IS110/IS902-family-protein	gnl\|CDD\|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	4.7896e-29
AP018449.1\|BBB93484.1\|4700086_4700539_-\|CRISPR-associated-protein	gnl\|CDD\|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	9.33494e-33
AP018449.1\|BBB93495.1\|4712982_4713438_-\|glyoxalase-like-domain-protein	gnl\|CDD\|366361	pfam00903, Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily.	1.83568e-10
AP018449.1\|BBB93492.1\|4711070_4711307_-\|hypothetical-protein	gnl\|CDD\|274902	TIGR03986, CRISPR-associated_protein, CRISPR-associated protein. Members of this protein family, part of the larger RAMP family, are found exclusively in species with CRISPR systems, in local contexts containing other RAMP (Repeat-Associated Mystery Proteins).	9.08026e-08

>AP018449.1|BBB93490.1|4707967_4708837_-|putative-S-adenosyl-L-methionine-dependent-methyltransferase
MANKKSGQTAFNVAAIRLIEQYQPKDLRLFTDPVIKNLFNWPNRFLLGFKIIRDWLIRFSDKQTKGIYGSNICRTRYIDDSLQSAIENGIEQVVILGAGLDTRPYRILGRDQIKFFEVDMPSVQDYKKKKVESYLGSLPDNVVFIPIDFNSQTLDEVFAGKGLDFSKPVVFIWEGVTPYITEKAVGNTLQFISKNSPGSIVIFTYILKTVIEKKSDINGVNDLVKYLEKYGVIWYFGLDPLNVAEFLKQFSLKLIEDVGASYYRENYLKPLGRRLDVSEIERIAYAMVI
>AP018449.1|BBB93489.1|4705610_4706891_+|transposase-IS116/IS110/IS902-family-protein
MKKADLLSTLFVGIDVSSRENVVCAIDYEAQKLLRFSVPNNHPGAIEMAEKLHAFLYGNRDINKLMLALESTSFYGIHIANYLSSCELLMPFHTHVYCLNPKMIANYKKSYIDLGKNDAVDAFVIADFARVGRITTAPWRGSQFLALQRLTRHRLHIAASLTREKTYMLSNIFLKFSQLSMLHEDQQPFSDHYGATASSVLTDFLSTEDIANMPLQALIDHIGQKGKNRFVNPGHTASLLQQAARNSYRLDKCLYEPLTLSIASSFNLISAYESEIKAINKAIEKTLKGLDPNAYHSLLSIPGIGPVYAAGIIAEIGSIDAFNSHSAFAKYAGLVWRENQSGNFRADDTVLSKAGNSYLRYYLIEAASHVKNHIPEYAAFYHKKYDEVKTHQHKRALALTARKFIRLIFGLLVNHQLYSKSRVSQI
>AP018449.1|BBB93488.1|4704308_4705253_-|hypothetical-protein
MLIEGAETSQYRAGSALQRKWYTVETLTPMAMHGANSRGDPQFRIPSLRGLLRYWWRAVQYETDPAKLLPKEEELFGGTQTEQSGKSLLRLVLHPPNFLLEEYPLLNHKPRTKDKSFTQVLKASQFLSIEASTYQFTRSDKWSHFQDALELALLLTGMGQRARRGFGAVQWQEHQFDSVESYGQRLCEVLSRLNVPIMSGITNGCLVKAVFNSGQLPPHPTLMAVWLGKPYEDNAAGVDCLLNDYGHASHLRSRASLGGIYPRFASPLWGSVRRIAGQLYPVISELQSAYSRKTPAVDYESDRNAFLQTLGVNI
>AP018449.1|BBB93487.1|4702662_4704309_-|CRISPR-associated-protein
MPQQYAIFSIGPVQSFIAAARKLEDLWGGSYLLSYLIESTIANLYAAEASFELIYPRITAQEIKAKIGSQDPSLSIAHLPNRITFTLDTDDEGAVQLLKRAELHVRKEIGTLCAKAVELVFAEQKNIIDSLQDQIWQQTEAFLEVYWIVQSVGQTGGLQRQVVETRFQTLKNQRRLCPHQENGLACTLYPALDALCHEPLADKDRYGDLRRKLENTWEQRSPVFRPANDHDEGELEKARIRNREYLCAISLVKRMARDIFQRHYRCSNNIFSKYESVVEIGGQEAKYYAVLLMDGDNMGQRFADGSDVQELSRRLSRFSREAVPEIVSKHKGILIYAGGDDVLALFPVNQVLEAADALRHAFASEKEGLGTGATSSTGIAIGHKTSPLQQALNQARLLEATAKSYCSPSGNEKNALAIAVRTRSGEHLGPLVLPWQLYERPTTEYLQEFIAALEKELSPTFVYRFAQAFQPFLPNSYRSQAMPQLRREIIETEYRRLVKRAVRKRSEIEQTYELAGPSFHFYDILGLGAFIDLLKILTFFNRRRAEYE
>AP018449.1|BBB93486.1|4701497_4702670_-|CRISPR-associated-protein
MSKLSLVPADSFFFKGHLTTELGTPSHLVGLFPPRPNTVYGALRAAYIHRHSTFAEFRRGKGGPVKQWMGTPASYGAFRQRAILLAKNRDYLLPLPLDYNFYRLKNSDAGTWRALPLHLEPNSSASSAGVSWTLGLPDREKTAGKTASPGGRYLRLEDWKAGVLQQQSFSAILSLEDDIINDYAKTGIAIGRDSRTAERSYFYQMNMMNLKADCALVALSEPCPDFSEVPLVSLGGENRPWFLSQETNDWKLWSEEQLEEIKSQLQRTPIARIILLTPALWPNNLSFLLDLQTEGEIWQLTPDIEVEPITWATARPELYGGWDIVRHRPKPRQWMMPAGTVIYVKIRENDISPILALADGFTLFADQEECSGMEGFGFAVIAGIKESNQY
>AP018449.1|BBB93485.1|4700522_4701485_-|RAMP-superfamily-protein
MFTIARPFLLHAVTSVHAGSGSEIGTVDLPIQREKHTGYPKIESSSLKGALRHDLAVGIKNKPEEQEKFKWVFGSKPQEEEHDNESQASALSFIDARILLFPVRSLRGTFAWITCRNVLERFNREMTLLCSDKTSSVPQWPLEGVEPETTSSQAMLVGNRDKIVLEEYTMQTKQSGATQSLAERIAQSLGADVPLGIKERLVVLTDDQFADFVKMSTEINARIKVGDSGTTDRGLWYEENVPPETVFYSAVLIGQVRESNKKGADTGEDRMGTLTTDEDVRRYVGEHFPSVFQLGGSNTIGKGILRLIWLEGGAGHDKTE
>AP018449.1|BBB93484.1|4700086_4700539_-|CRISPR-associated-protein
MTRQNEAFCQIEEGRATFAFEQVKQAVEKLAGNAQSYKSYVRSLPSLIQVNGLGQALAFCYARKNKNKYIAYRDIYESIFNWLQRKFPDHFQQESELVEEAVKLRSEDYRMITMEVLALLNWMGRFAEGMIEDPLREDEEQANPSEGEAL
>AP018449.1|BBB93483.1|4698830_4700090_-|RAMP-superfamily-protein
MSQTSTQVLHPADTQEMFQQFSSPDHLWYSMNYNQQADRQAREKEIDREEKKKNGDPDAVRYMFRKNLNHRDGLERITALGRTVDKQRLQALADLPEHYQVRILQATPMGGIIHGLGGAHVRENSLTIHPVYGFLYIPGSSLKGVVRRWFIEAFLGGKESHWDEKTEPWRQAATLGRLVFGTQASVGAVQFFDIFLIEGLQVKPDILTPHFSGYYAGKGTQAPEDTLNPVPNQFYIIQVQTADIVFTLRDTPAAAAMNLSADDLIGLLTDWVRTALQELGLGGKTSSGYGRFMDIQDVTLERFLPVKEKRLEEKKKEEQRKEQAEEQRRLSAMTSSERLIHDIRSLNSSTEEDIQRSKNDIFNQVLNAQNKEAAQCLKTYWESTNNWIIKRGSKKQNKQAVKVQKVRQLLGDWNDLLGN
>AP018449.1|BBB93482.1|4697629_4698820_-|hypothetical-protein
MGSMFFISYSHEDDKDTKNIQQLDHVLKAYGLKTWIDQKNLPAGRMEQNIKKIIECERVEGYVLYVSQHSLRSHPVCEWELKPALKKRDHDPNFIMFFVLEGITFEEFKELSWRKFGVDLTQYYYQRIEEGNRLQTYHSVAQKLLDSKLQQVTEPLSEWVLNLYARGEDPKTSNKQPHLQIDLSYFFAERIPQQQEWEEIIIPAWQGIKRKIAGCPGRIHLQSNVLLPTGIAFGRVFHAATKYCLTFSDQEGWQTEGSVKDKAPLRQESHRGREDSDNIILEVGIAQDTRKATNDYVEKHHLDYRAWHSLKAEECSRNFIASPQHAYDTMTQIAEKIRKCSSEYPGNILIHLFYAGPLALAFMIGHCLNAVGPIQLYEFHKGLQQYEQGLLLKMND
>AP018449.1|BBB93481.1|4695779_4696649_-|putative-S-adenosyl-L-methionine-dependent-methyltransferase
MANKKSGQTAFNVAAIRLIEQYQSKDLRLFTDPVIKNLFNWPNRFLLGFKIIRDWLIRFSDKQTKGIYGSNICRTRYIDDSLQSAIENGIEQVVILGAGLDTRPYRILGRDQIKFFEVDMPSVQDYKKKKVESYLGSLPDNVVFIPIDFNSQTLDEVFAGKGLDFSKPVVFIWEGVTPYITEKAVGNTLQFISKNSPGSIVIFTYILKTVIEKKSDIDGVNDLVKYLEKYGVIWYFGLDPLNVAEFLKQFSLKLIEDVGASYYRENYLKPLGRRLDVSEIERIAYATVI
>AP018449.1|BBB93491.1|4710736_4710988_-|hypothetical-protein
MGGEAYFDAVHFLQYGQSKQKFLSIPKRWDKLSDETEGGAILSIGACKEDIRAKGNQWDKKSRVSIVLRKAKIVFILFVVDLQ
>AP018449.1|BBB93492.1|4711070_4711307_-|hypothetical-protein
MKGLHGKIYFYNIIQGELGLLLLSLRPPAVLQSHDMLRWPSSTAWNYSRFMILLGGAKPYGYGKVRITVKQVMLEKKV
>AP018449.1|BBB93493.1|4711556_4712831_-|cystathionine-beta-lyase-MetC
MEGKIPEASIKCEARRTFLALCSPKTRLLHEPVSDPYLVCGHPNPAGLGDAGRFSQMGSWGQSSVLFPKLETYRTADKCGRAPYGGAEYGVPQTPEADAVCRKIAALHRGHGAVICPSGLSAIATTLDAFSPKAVLIPDNVYGPMLRFLNRRRIKPIRYPAGASADEFRSALLKARSEYSLREDLLVYIEAPGSGTFEIPDIDGMIAIAQNAKLRTVMDNTWASHVRFQPLERGIDIVVQATTKYEGGYGDTPSGIVIAKHPQDLQIIADELRATGNGAVAPMTCSRLYHRIDSTEERLNQHAHTAQRLIEWFLKQPFVTDVLSPTLETSPYHERFQRYFGKGNGLFSVVFPPDLPAKQVEAFVDALNLFWVAESWGGHLSLVLPVHAKREVTPLPDGYILRFHAGLEDYQDLLRDLNQAAGCL
>AP018449.1|BBB93494.1|4712872_4712986_-|hypothetical-protein
MRIIFPKVIYEHLIGEKLESGSGNESCLSVKKDLFVH
>AP018449.1|BBB93495.1|4712982_4713438_-|glyoxalase-like-domain-protein
MNLIENNKVYGIHHIAIRAKDFEKTVRFYIEVLDFNIRHIWSLPEFNLKQAAMLKSRDGSSFIEIFDNDADIAAEGRRPLAGEEPVQGSLLHFSVLVDNAELAYSRALSAGASPCVPPMTLFLGDPPLAVRNALVYSPNGEVIEFMESNNL
>AP018449.1|BBB93496.1|4713468_4714479_-|NADH-oxidase
MLEILEPIRIKNVDFKNRVVMAPMVPFGMPIQPSGSMSDKVLQHYLQRASNGMGLIITQAFSVTSRKKHDGGIGVYSDDHKAYLKTLTKVYHAEGTRIFVQLAYPSAGFHRGDSINDLSEYDIKTIKDEFVYAAKLCKEAGCDGIELHGAHGFFLNIMASSLANKREDQYGGDLDGRLRLVKNIVEEIRTFADEPFIISYRMGWNGSLENDIRMAQALERGGIELLHISSGIPAVRKMEIPDEFFFNEIVYTGIQIKKNVSIPVIVVNDIRTLSRGNYLIENGLCDFAAYGRPFLADAAFMTTSLNNCDYEPCLRCKTCQWFINGEKCPAKINGVG
>AP018449.1|BBB93497.1|4714610_4714988_+|HTH-type-transcriptional-activator-HxlR
MESLCRSKQAPFEYTLEIINGKWKLRIIYELGCEATLRYGALKRSIPHITHKILSTQLKELKNDGLIIRKEYPQIPPRVEYALSEKGLSIFPIIFCQKGLSPAIISYRYCDSSSFFILRSDELLR
>AP018449.1|BBB93498.1|4715119_4715701_-|HTH-type-transcriptional-repressor-Bm3R1
MEKKKGRPRNAATEKAILAASYDLLLESGFGTVTVEKIAERAKVSKATIYKWWPNKAAVVMDGFLSAAMSRLPVPDTGSVINDIVIQASNLAKFLTSREGKVINELIAEGQFDLKLAEEYRSRYFNPRRLDSRRILERGMQRGELKKDLDIELCIDLIYGPLFYRLLVTGEKLDESFIRVLINYAFEGIQLKR
>AP018449.1|BBB93499.1|4715904_4717092_+|purine-efflux-pump-PbuE
MNTVQSKTRQVPNWITVLLAIACGVIVANLYYAQPLVGPISTDTHLPLASAGLIVTLTQIGYVAGLLFIVPLCDLIENRRLISSTLVIVICALVAASLTHHALFFLMASMFIGLGSVATQILVPYAAHLATEERRGQVVGNVMSGLLLGIMLARPVASFVTDLWGWQAIFILSAGITTILAVLLAFVLPARNPLPTTNYGGLIRSLWSLFKTKAVLRRRAFYQACLFSAFSLFWTVIPLWLASHFHLSQQGIALFALAGVAGAIAAPIAGRLADKGWTKRLTGLAIVIAILSFLLTHIFKDSSTIALMLFVIAAITLDMAVSGNLVLGQRAIYSLGSEIRGRVNGVFMAVFFIGGAIGSALGGWAYAYGGWMFASILGLSIPVVALLYYFTEKNN
>AP018449.1|BBB93500.1|4717659_4718313_-|hypothetical-protein
MLNRHLAGFEVINRSGDPSIRSILAELELAVANEYSIEIKYRTSHDEQPRNRVIDPYGMLYWNNVKSNDPQEGEMLAQYLSKFPVERLNQLTVYGGDKPVADVHKILPNLRALSMATLKKSLLSYFAIGWTGYVPPACRHTELHIPEKYAPWLWGWPNRFLNRMADADTRVILVAGEGEFSAGFDTPEDIKRLPPNYTGGIWTNRIDRIAPLFKNNE

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Crispr_ID: AP018449_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018449_9

4751728-4754560

TypeI-B,TypeIII-A?

Consensus_repeat	Method
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CRT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	PILER-CR
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CRISPRCasFinder

42 spacers

cas2,cas1,cas4,cas3,cas5,cas7,cas8b1

The CRISPR arrays of AP018449_9

>merge|AP018449|9|4751728-4754560|CRT,PILER-CR,CRISPRCasFinder
TTCCTCCACCCATACTTATAGGCTACAAACGATTAGGCGCTAACTAATCTTCACTTTTATTATACCTGTTTCAATCCCTTATAGGTAAGCTACAAACCAGCAACGCAGGGGATTCCTATAAACCTCAGAAGCCGGTTTCAATCCCTTATAGGTAAGCTACAAACATAGGTCCGCGATATTTGTTTTTGCCGTTACAAACGGTTTCAATCCCTTATAGGTAAGCTACAAACAGTCTATTGACGATGCCGTGGCAAAATTGATTAAATAGTTTCAATCCCTTATAGGTAAGCTACAAACTGAACTTGGAACAAAGCCAGATGGTACGACTGGAATGTTTCAATCCCTTATAGGTAAGCTACAAACAAGACTCTTGGAGCGAGAGCTATCGCTATTACTGTGTTTCAATCCCTTATAGGTAAGCTACAAACTTGGCTGCACTTATATCCATCTGGTCAACGGCTCTATGTTTCAATCCCTTATAGGTAAGCTACAAACTGTGAAGGTGTTCCGGCCGCATACACCCCGATAGAGTGTTTCAATCCCTTATAGGTAAGCTACAAACAATAATATCCGTTGGCGCTATAGACAAGAAGGTAAATGTTTCAATCCCTTATAGGTAAGCTACAAACGTTTTGCAGCCTGCGTCTCGGACATATTTCCTTCTATGTTTCAATCCCTTATAGGTAAGCTACAAACCTTGCGCCTCCAGAGTGAGCGTGTTTTGATATCCTAGTTTCAATCCCTTATAGGTAAGCTACAAACGATAAGTAAGCTACCGTAGGAGCAATTAGAACGGTAGTTTCAATCCCTTATAGGTAAGCTACAAACCTGCAATGGTGCGCTGAAGAGGATTCCCTAGACTGGGAGTTTCAATCCCTTATAGGTAAGCTACAAACGTAGCTACCCCCCGGCCAAACCATTTAAATATCTCCCAGTTTCAATCCCTTATAGGTAAGCTACAAACTGAGGGCCTTGCTCCTCAGGCTTTTTTGTTATTACAAGTTTCAATCCCTTATAGGTAAGCTACAAACATGTGTATGTTGGACCAGGTAATATTTCTTATTTTCGGTTTCAATCCCTTATAGGTAAGCTACAAACGGGAAATATCATTCCCCTGACACAATTAGATTTCCTCAGTTTCAATCCCTTATAGGTAAGCTACAAACGTTGACGTGATTGCCGATATGGCACGGAATTTAGTGTTTCAATCCCTTATAGGTAAGCTACAAACTTTGGCAATATCAACCGGAATATCAGTCATATCGATGTTTCAATCCCTTATAGGTAAGCTACAAACCGCCCGAATTTTTACCGGCGCCAATTTTTGCATCATGAGTTTCAATCCCTTATAGGTAAGCTACAAACCTGCGCCTATCTTTGGAAAAGCACTGACCAGGGGCGTTTCAATCCCTTATAGGTAAGCTACAAACTGACGGCCTGTAGCTTGGTCGGTGGTATGAACAGCGACTGTTTCAATCCCTTATAGGTAAGCTACAAACTACAGATCGTCAATACGGGCGTGGCAATTACCACTTAGTTTCAATCCCTTATAGGTAAGCTACAAACATAATCGTTGCGGTTGTTGTTCTGCGGATTTTAGGAGTTTCAATCCCTTATAGGTAAGCTACAAACAGTGATCCTGGATCAAGAGCCAACCACATTAAAACATCGTTTCAATCCCTTATAGGTAAGCTACAAACGGAATCGCGTGCCTATTGGTGGATTGATAGCGGCAGAGGTTTCAATCCCTTATAGGTAAGCTACAAACTGATTGCGGTACACCTGACCGGTCCGCCATACCATGTTTCAATCCCTTATAGGTAAGCTACAAACCGAAAAAACAAAGACAAAGTATATATCAATCGTACCAGGGTTTCAATCCCTTATAGGTAAGCTACAAACCGAATTGTCTTATTGCTATCGCTCCCTTTTGAACAAGTTTCAATCCCTTATAGGTAAGCTACAAACATTTTTTCCTTAGCGTCATCCTGTTTATAGGAACTAAGTTTCAATCCCTTATAGGTAAGCTACAAACCATAAAAACTATCTCTACATCCCGGACATGGGAAGTAGTTTCAATCCCTTATAGGTAAGCTACAAACCATTATTTCGCGCCACTCCAAGGAGTACAAGGAGAAGTTTCAATCCCTTATAGGTAAGCTACAAACCCATGGCTTTCTATGATTTCATTTATTTGATCTTGTGTGTTTCAATCCCTTATAGGTAAGCTACAAACAGCCCTGACTGCCGAACTAACACGCAGGGGCATGAGGTTTCAATCCCTTATAGGTAAGCTACAAACCTATCAATTCCATTTAGCGATATTGCCGCACTACTATGTTTCAATCCCTTATAGGTAAGCTACAAACAAAGCATTAAGAGAATTCATATGTTGGGATATCAAACGAGTTTCAATCCCTTATAGGTAAGCTACAAACTATCAATTCACGGACTATGGAGATCCTGCTGGCAAGTTTCAATCCCTTATAGGTAAGCTACAAACATTGAACCCGGAAGGAGGTTAGGGAGTGTCAATTTGTTTCAATCCCTTATAGGTAAGCTACAAACTGACGGACCGCTCCGTGCACGACGTGGCGGCTGATGGGTTTCAATCCCTTATAGGTAAGCTACAAACTAAAAGCTGTTCCGGTTTAATTGCCTTGTTCTCGGGTTTCAATCCCTTATAGGTAAGCTACAAACTCGGTGATCCGAACAAAGGGCCTTGCTACAACGGGGGTTTCAATCCCTTATAGGTAAGCTACAAACGTGGACAAGACTGGAATTTTTCCACGACAAGACCAGGGTTTCAATCCCTTATAGGTAAGCTACAAAC

>AP018449|9|7|4751728-4754560|CRT
TTCCTCCACCCATACTTATAGGCTACAAAC	GATTAGGCGCTAACTAATCTTCACTTTTATTATACCT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAGCAACGCAGGGGATTCCTATAAACCTCAGAAGCCG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATAGGTCCGCGATATTTGTTTTTGCCGTTACAAACG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTCTATTGACGATGCCGTGGCAAAATTGATTAAATA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGAACTTGGAACAAAGCCAGATGGTACGACTGGAAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAGACTCTTGGAGCGAGAGCTATCGCTATTACTGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTGGCTGCACTTATATCCATCTGGTCAACGGCTCTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGTGAAGGTGTTCCGGCCGCATACACCCCGATAGAGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AATAATATCCGTTGGCGCTATAGACAAGAAGGTAAAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTTTTGCAGCCTGCGTCTCGGACATATTTCCTTCTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTTGCGCCTCCAGAGTGAGCGTGTTTTGATATCCTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GATAAGTAAGCTACCGTAGGAGCAATTAGAACGGTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTGCAATGGTGCGCTGAAGAGGATTCCCTAGACTGGGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTAGCTACCCCCCGGCCAAACCATTTAAATATCTCCCA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGAGGGCCTTGCTCCTCAGGCTTTTTTGTTATTACAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATGTGTATGTTGGACCAGGTAATATTTCTTATTTTCG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GGGAAATATCATTCCCCTGACACAATTAGATTTCCTCA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTTGACGTGATTGCCGATATGGCACGGAATTTAGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTTGGCAATATCAACCGGAATATCAGTCATATCGAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGCCCGAATTTTTACCGGCGCCAATTTTTGCATCATGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTGCGCCTATCTTTGGAAAAGCACTGACCAGGGGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGACGGCCTGTAGCTTGGTCGGTGGTATGAACAGCGACT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TACAGATCGTCAATACGGGCGTGGCAATTACCACTTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATAATCGTTGCGGTTGTTGTTCTGCGGATTTTAGGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTGATCCTGGATCAAGAGCCAACCACATTAAAACATC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GGAATCGCGTGCCTATTGGTGGATTGATAGCGGCAGAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGATTGCGGTACACCTGACCGGTCCGCCATACCAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGAAAAAACAAAGACAAAGTATATATCAATCGTACCAGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGAATTGTCTTATTGCTATCGCTCCCTTTTGAACAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTTTTTCCTTAGCGTCATCCTGTTTATAGGAACTAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATAAAAACTATCTCTACATCCCGGACATGGGAAGTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATTATTTCGCGCCACTCCAAGGAGTACAAGGAGAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CCATGGCTTTCTATGATTTCATTTATTTGATCTTGTGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGCCCTGACTGCCGAACTAACACGCAGGGGCATGAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTATCAATTCCATTTAGCGATATTGCCGCACTACTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAAGCATTAAGAGAATTCATATGTTGGGATATCAAACGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TATCAATTCACGGACTATGGAGATCCTGCTGGCAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTGAACCCGGAAGGAGGTTAGGGAGTGTCAATTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGACGGACCGCTCCGTGCACGACGTGGCGGCTGATGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAAAAGCTGTTCCGGTTTAATTGCCTTGTTCTCGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TCGGTGATCCGAACAAAGGGCCTTGCTACAACGGGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTGGACAAGACTGGAATTTTTCCACGACAAGACCAGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC

>AP018449|9|7|4751795-4754560|PILER-CR
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAGCAACGCAGGGGATTCCTATAAACCTCAGAAGCCG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATAGGTCCGCGATATTTGTTTTTGCCGTTACAAACG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTCTATTGACGATGCCGTGGCAAAATTGATTAAATA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGAACTTGGAACAAAGCCAGATGGTACGACTGGAAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAGACTCTTGGAGCGAGAGCTATCGCTATTACTGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTGGCTGCACTTATATCCATCTGGTCAACGGCTCTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGTGAAGGTGTTCCGGCCGCATACACCCCGATAGAGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AATAATATCCGTTGGCGCTATAGACAAGAAGGTAAAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTTTTGCAGCCTGCGTCTCGGACATATTTCCTTCTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTTGCGCCTCCAGAGTGAGCGTGTTTTGATATCCTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GATAAGTAAGCTACCGTAGGAGCAATTAGAACGGTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTGCAATGGTGCGCTGAAGAGGATTCCCTAGACTGGGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTAGCTACCCCCCGGCCAAACCATTTAAATATCTCCCA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGAGGGCCTTGCTCCTCAGGCTTTTTTGTTATTACAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATGTGTATGTTGGACCAGGTAATATTTCTTATTTTCG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GGGAAATATCATTCCCCTGACACAATTAGATTTCCTCA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTTGACGTGATTGCCGATATGGCACGGAATTTAGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTTGGCAATATCAACCGGAATATCAGTCATATCGAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGCCCGAATTTTTACCGGCGCCAATTTTTGCATCATGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTGCGCCTATCTTTGGAAAAGCACTGACCAGGGGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGACGGCCTGTAGCTTGGTCGGTGGTATGAACAGCGACT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TACAGATCGTCAATACGGGCGTGGCAATTACCACTTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATAATCGTTGCGGTTGTTGTTCTGCGGATTTTAGGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTGATCCTGGATCAAGAGCCAACCACATTAAAACATC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GGAATCGCGTGCCTATTGGTGGATTGATAGCGGCAGAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGATTGCGGTACACCTGACCGGTCCGCCATACCAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGAAAAAACAAAGACAAAGTATATATCAATCGTACCAGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGAATTGTCTTATTGCTATCGCTCCCTTTTGAACAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTTTTTCCTTAGCGTCATCCTGTTTATAGGAACTAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATAAAAACTATCTCTACATCCCGGACATGGGAAGTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATTATTTCGCGCCACTCCAAGGAGTACAAGGAGAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CCATGGCTTTCTATGATTTCATTTATTTGATCTTGTGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGCCCTGACTGCCGAACTAACACGCAGGGGCATGAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTATCAATTCCATTTAGCGATATTGCCGCACTACTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAAGCATTAAGAGAATTCATATGTTGGGATATCAAACGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TATCAATTCACGGACTATGGAGATCCTGCTGGCAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTGAACCCGGAAGGAGGTTAGGGAGTGTCAATTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGACGGACCGCTCCGTGCACGACGTGGCGGCTGATGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAAAAGCTGTTCCGGTTTAATTGCCTTGTTCTCGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TCGGTGATCCGAACAAAGGGCCTTGCTACAACGGGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTGGACAAGACTGGAATTTTTCCACGACAAGACCAGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC

>AP018449|9|9|4751795-4754560|CRISPRCasFinder
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAGCAACGCAGGGGATTCCTATAAACCTCAGAAGCCG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATAGGTCCGCGATATTTGTTTTTGCCGTTACAAACG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTCTATTGACGATGCCGTGGCAAAATTGATTAAATA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGAACTTGGAACAAAGCCAGATGGTACGACTGGAAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAGACTCTTGGAGCGAGAGCTATCGCTATTACTGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTGGCTGCACTTATATCCATCTGGTCAACGGCTCTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGTGAAGGTGTTCCGGCCGCATACACCCCGATAGAGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AATAATATCCGTTGGCGCTATAGACAAGAAGGTAAAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTTTTGCAGCCTGCGTCTCGGACATATTTCCTTCTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTTGCGCCTCCAGAGTGAGCGTGTTTTGATATCCTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GATAAGTAAGCTACCGTAGGAGCAATTAGAACGGTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTGCAATGGTGCGCTGAAGAGGATTCCCTAGACTGGGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTAGCTACCCCCCGGCCAAACCATTTAAATATCTCCCA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGAGGGCCTTGCTCCTCAGGCTTTTTTGTTATTACAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATGTGTATGTTGGACCAGGTAATATTTCTTATTTTCG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GGGAAATATCATTCCCCTGACACAATTAGATTTCCTCA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTTGACGTGATTGCCGATATGGCACGGAATTTAGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TTTGGCAATATCAACCGGAATATCAGTCATATCGAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGCCCGAATTTTTACCGGCGCCAATTTTTGCATCATGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTGCGCCTATCTTTGGAAAAGCACTGACCAGGGGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGACGGCCTGTAGCTTGGTCGGTGGTATGAACAGCGACT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TACAGATCGTCAATACGGGCGTGGCAATTACCACTTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATAATCGTTGCGGTTGTTGTTCTGCGGATTTTAGGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTGATCCTGGATCAAGAGCCAACCACATTAAAACATC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GGAATCGCGTGCCTATTGGTGGATTGATAGCGGCAGAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGATTGCGGTACACCTGACCGGTCCGCCATACCAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGAAAAAACAAAGACAAAGTATATATCAATCGTACCAGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CGAATTGTCTTATTGCTATCGCTCCCTTTTGAACAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTTTTTCCTTAGCGTCATCCTGTTTATAGGAACTAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATAAAAACTATCTCTACATCCCGGACATGGGAAGTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATTATTTCGCGCCACTCCAAGGAGTACAAGGAGAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CCATGGCTTTCTATGATTTCATTTATTTGATCTTGTGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGCCCTGACTGCCGAACTAACACGCAGGGGCATGAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTATCAATTCCATTTAGCGATATTGCCGCACTACTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAAGCATTAAGAGAATTCATATGTTGGGATATCAAACGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TATCAATTCACGGACTATGGAGATCCTGCTGGCAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTGAACCCGGAAGGAGGTTAGGGAGTGTCAATTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGACGGACCGCTCCGTGCACGACGTGGCGGCTGATGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAAAAGCTGTTCCGGTTTAATTGCCTTGTTCTCGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TCGGTGATCCGAACAAAGGGCCTTGCTACAACGGGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTGGACAAGACTGGAATTTTTCCACGACAAGACCAGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
AP018449.1\|BBB93532.1\|4759354_4761622_-\|CRISPR-associated-endonuclease/helicase-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
AP018449.1\|BBB93535.1\|4763237_4763654_-\|hypothetical-protein	cas8b1	mkCas0119_cas8b1_CAS-I-B	gnl\|CDD\|378190
AP018449.1\|BBB93531.1\|4757033_4757462_-\|nucleotidyltransferase-domain-protein	unknown	unknown	gnl\|CDD\|376187
AP018449.1\|BBB93527.1\|4754782_4755094_-\|CRISPR-associated-endoribonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
AP018449.1\|BBB93534.1\|4762294_4763203_-\|hypothetical-protein	cas7	cd09690_cas7_CAS-I-B	gnl\|CDD\|274217
AP018449.1\|BBB93521.1\|4742813_4744067_-\|poly-beta-1,6-N-acetyl-D-glucosamine-synthase	unknown	unknown	gnl\|CDD\|133045
AP018449.1\|BBB93524.1\|4746583_4747717_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93518.1\|4738159_4738261_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93529.1\|4756110_4756611_-\|hypothetical-protein	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
AP018449.1\|BBB93517.1\|4736811_4738035_-\|stage-II-sporulation-protein-E	unknown	unknown	gnl\|CDD\|225118
AP018449.1\|BBB93526.1\|4751404_4751695_-\|sirohydrochlorin-cobaltochelatase	unknown	unknown	gnl\|CDD\|368778
AP018449.1\|BBB93528.1\|4755090_4756083_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
AP018449.1\|BBB93520.1\|4740768_4742817_-\|cellulose-synthase-regulator-protein	unknown	unknown	gnl\|CDD\|377001
AP018449.1\|BBB93519.1\|4738746_4740738_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|173412
AP018449.1\|BBB93533.1\|4761572_4762289_-\|CRISPR-associated-protein	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
AP018449.1\|BBB93536.1\|4763650_4765177_-\|CRISPR-associated-protein	cas8b1	cd09730_cas8b1_CAS-I-B	gnl\|CDD\|378190
AP018449.1\|BBB93522.1\|4744118_4745747_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200549
AP018449.1\|BBB93525.1\|4750886_4751363_-\|sirohydrochlorin-cobaltochelatase-CbiKP-precursor	unknown	unknown	gnl\|CDD\|368778
AP018449.1\|BBB93523.1\|4745733_4746597_-\|putative-diguanylate-cyclase-AdrA	unknown	unknown	gnl\|CDD\|143635
AP018449.1\|BBB93530.1\|4756612_4757044_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366864

Protein	Function_ID	Function_description	E-value
AP018449.1\|BBB93532.1\|4759354_4761622_-\|CRISPR-associated-endonuclease/helicase-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	4.70822e-45
AP018449.1\|BBB93535.1\|4763237_4763654_-\|hypothetical-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	1.83152e-08
AP018449.1\|BBB93531.1\|4757033_4757462_-\|nucleotidyltransferase-domain-protein	gnl\|CDD\|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	2.39204e-28
AP018449.1\|BBB93527.1\|4754782_4755094_-\|CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.67459e-32
AP018449.1\|BBB93534.1\|4762294_4763203_-\|hypothetical-protein	gnl\|CDD\|274217	TIGR02590, hypothetical_protein_MM_0563, CRISPR-associated protein Cas7/Csh2, subtype I-B/HMARI. This model represents one of two closely related CRISPR-associated proteins that belong to the larger family of TIGR01595. Members are the Csh2 protein of the Hmari subtype of CRISPR/cas system. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. The related model is TIGR02589, the Csd3 protein of the Dvulg CRISPR subtype.	1.40396e-76
AP018449.1\|BBB93521.1\|4742813_4744067_-\|poly-beta-1,6-N-acetyl-D-glucosamine-synthase	gnl\|CDD\|133045	cd06423, CESA_like, CESA_like is the cellulose synthase superfamily. The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.	4.0083e-63
AP018449.1\|BBB93536.1\|4763650_4765177_-\|CRISPR-associated-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	6.0826e-23
AP018449.1\|BBB93529.1\|4756110_4756611_-\|hypothetical-protein	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	7.71176e-70
AP018449.1\|BBB93517.1\|4736811_4738035_-\|stage-II-sporulation-protein-E	gnl\|CDD\|225118	COG2208, RsbU, Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription].	1.08229e-20
AP018449.1\|BBB93526.1\|4751404_4751695_-\|sirohydrochlorin-cobaltochelatase	gnl\|CDD\|368778	pfam06180, CbiK, Cobalt chelatase (CbiK). This family consists of several bacterial cobalt chelatase (CbiK) proteins (EC:4.99.1.-).	2.13884e-26
AP018449.1\|BBB93528.1\|4755090_4756083_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	3.30429e-176
AP018449.1\|BBB93520.1\|4740768_4742817_-\|cellulose-synthase-regulator-protein	gnl\|CDD\|377001	pfam03170, BcsB, Bacterial cellulose synthase subunit. This family includes bacterial proteins involved in cellulose synthesis. Cellulose synthesis has been identified in several bacteria. In Agrobacterium tumefaciens, for instance, cellulose has a pathogenic role: it allows the bacteria to bind tightly to their host plant cells. While several enzymatic steps are involved in cellulose synthesis, potentially the only step unique to this pathway is that catalyzed by cellulose synthase. This enzyme is a multi subunit complex. This family encodes a subunit that is thought to bind the positive effector cyclic di-GMP. This subunit is found in several different bacterial cellulose synthase enzymes. The first recognized sequence for this subunit is BcsB. In the AcsII cellulose synthase, this subunit and the subunit corresponding to BcsA are found in the same protein. Indeed, this alignment only includes the C-terminal half of the AcsAII synthase, which corresponds to BcsB.	9.03819e-27
AP018449.1\|BBB93519.1\|4738746_4740738_-\|hypothetical-protein	gnl\|CDD\|173412	PTZ00121, PTZ00121, MAEBL; Provisional.	3.6203e-11
AP018449.1\|BBB93533.1\|4761572_4762289_-\|CRISPR-associated-protein	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.63382e-31
AP018449.1\|BBB93522.1\|4744118_4745747_-\|hypothetical-protein	gnl\|CDD\|200549	cd10923, CE4_COG5298, Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria. This family corresponds to a group of uncharacterized bacterial proteins with high sequence similarity to the catalytic domain of the six-stranded barrel rhizobial NodB-like proteins, which remove N-linked or O-linked acetyl groups from cell wall polysaccharides and belong to the larger carbohydrate esterase 4 (CE4) superfamily. Some family members contain an additional copper amine oxidase N-terminal domain.	3.29695e-70
AP018449.1\|BBB93525.1\|4750886_4751363_-\|sirohydrochlorin-cobaltochelatase-CbiKP-precursor	gnl\|CDD\|368778	pfam06180, CbiK, Cobalt chelatase (CbiK). This family consists of several bacterial cobalt chelatase (CbiK) proteins (EC:4.99.1.-).	2.91907e-55
AP018449.1\|BBB93523.1\|4745733_4746597_-\|putative-diguanylate-cyclase-AdrA	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	5.35191e-17
AP018449.1\|BBB93530.1\|4756612_4757044_-\|hypothetical-protein	gnl\|CDD\|366864	pfam01934, DUF86, Protein of unknown function DUF86. The function of members of this family is unknown.	3.40464e-35

>AP018449.1|BBB93526.1|4751404_4751695_-|sirohydrochlorin-cobaltochelatase
MKGKTILAVSFGTTYPETLKLTIESVESKIKQSFPEFEVRRAFTSRMVIKRIFERDGIRIDTEIEALERLRIEGYQEYTFSRFILLPVKNMKRLKE
>AP018449.1|BBB93525.1|4750886_4751363_-|sirohydrochlorin-cobaltochelatase-CbiKP-precursor
MGRPILFYGGEEGKPDDYLIAINAIRNLFPALSAGEAAVLMGHGGLHPANAAYGALQVKLADAGLENVFVYTVEGFPSLAEVIKKLKTDNIKKVVLIPFMLVAGAHVMNDMIGDDKDSARSQVVSAGIEVRAYLQGMGENAAIQDIYIQHLKDIIDED
>AP018449.1|BBB93524.1|4746583_4747717_-|hypothetical-protein
MKIRIALLVFLVVLAVMVQFIFLNNTPNPNLTEAKVNQNPAAGKNPKPEEIQAFRFLRTRMQSPHGVIRYLVDAKSPAAFGVSESMGQAMEYTALLGDAKLFGKYAAFTDKYFKDPTGYYYWKIDVASKKGETTSALVDDLRIVKAYFIANEKKLGNYDKQIEKLAEAIYEFDVDAKGYPCDFYDGIAKKKADIVSLFYLDVETMEKLSKVNAKWSASHKNAIRILLNMPENQHGFYPQTFKIDTKQYIWPISINMVENLYTAIDAYNAGKSTSALVTFLKAQVKQGKVYNHYNSDGTPVNQDESTAVYALSTRFLALNNEWEAAEWCYHRTLDFQINDKKSFEGGFGEPETGLVYAFDQLEALLMLRMVEIKNDSQ
>AP018449.1|BBB93523.1|4745733_4746597_-|putative-diguanylate-cyclase-AdrA
MIASDKYIRKDILFFNLIMVFILAVIAIVLLYAPTMGTFNLFIPFACLLFNMIVSHNLGLQRGLMAGIVLTFAFGSYIIYETMIINRITEVNFAYIAWLFFFPLSSILAGQLSLVVSNYRRELENKKSLEQLVTIDASTGLYNSQGFFRKLEEEFVRAKRYKTCFSILLIKMSNFDELQVIYGEIDSIKILQSVAGKVELQTRFSDIKALISADILGIMLPETNEDGARIVIEKLHQALDRLTTEIRGTKKVIRIKPSIGISSIKESDTDVLEAYQRAKEELNYDRG
>AP018449.1|BBB93522.1|4744118_4745747_-|hypothetical-protein
MIEVRKKAIMFFLLAIFTFGICLPTSSYSSAPKLKTYIVYDSPNRFADSFPLVNALIEHLGHFDLACQPMALQEWKPGALQDAELIVYAGLSDVTLPQGLLQEMAHARRVIWFEKNIEQMAAYLHWQDFKLEGVFNGWSFINYKRDVFIDDWINVVIAQPGQNAQVFATVKDIVASKPLAWQRDNVYYCGLLEVHPKYMITLSGLLHQFIPNQNHNHSHSHKALLRIEDVSPLVNSEAVGAVIATITKYNIPFSIGVIPVGVTKDDRYIFLHERPNLLKVLKEAQDNGASIIMHGYTHQNKYSPKTGEGYEFWNARDDKPMENDDAFTSERIEAGIEELVRCGLTPVAFEPPHYAMSEAGYKVLSRYFNIFSGQIQISDKSDRLSLSLPYVTTSTYLNGMMVIPENMGYYDGKTFLVDHMLQSSEQILEIQDGFACFFYHGYLPPDKLPSIIEGLQKQGYEFYDLRQLPILVHSPKIKIIGRDGQLRVEVDAKLQSSWGSNPVDDNMFKKIGSVHITLLLLILGIFVVIIIRLRANANKHYE
>AP018449.1|BBB93521.1|4742813_4744067_-|poly-beta-1,6-N-acetyl-D-glucosamine-synthase
MLVDNLFIASLAATWLILFYHVILTIGGYRHFVKTLTSVEPDLELSEYPMVTVLIPAHNEEMVIGRTVDAMARLIYPQDRLEIIVVNDCSTDRTGKILAEKCAKYPQLKVVTLAPPLGAKGKSNALNNGLKASKGDYIVVYDADNTPERRAVLYLVHAILQDEKLGAVVGKFRTRNKEASLLTRFINVETLSFQWLLQAGRCHFFGITTIPGTNFIIRRSLLDSMGGWNVNALTEDTELTIRIYDSGYRIFWLPHAVTWEQEPETLRVWLKQRTRWAQGNMWIIGQYLFKLFTLRDLRISADIIYFTFTYFVFFVAIIVSDLIFILGILGLTQLTVSGPFNIIWLLAYALFIVETYISLSLERGEGNGKNLALTALMYFTYSQLWIILVFRASYLLLKRKLQKDSGFHWYKTERSAL
>AP018449.1|BBB93520.1|4740768_4742817_-|cellulose-synthase-regulator-protein
MTNKMIKIVCSMFSLLLLLLILSFGQSAKAAPSASGDSYTLRLFNVNTVLRNPNDSISGYFDIYQGSAITEPAVLDLWYSYSPTTKTELSFITISVNGVPVDSRPLEPAQAAMVNWLVALPANQIKTGFNEVNISVVHRSIDGLCRDIDNEANWFIIRPETRISFKVARSPYSLASYPMPFLDEYLASKVNTVFYLPDNSDQVMLASLFNLATNWGARGLTGVPQRMEVRLGQPGQVPANEVVLGLTSQWQGNQNKTAVLTLAGLSDGFNRLLITGDDTSSMAKAMDALSRPQLVKTFLGQQTALSTNLPADKQGTVKKENGVYTLVDLGYQQDIAVAGAFHQEAVINVPRPSNYKAGDGSYIELHFHHAKILDPKKSAVTIYINDVPIRSAALLAENAEKGILKAPIPVSELNKPSWRVRFGFYHDIGVIDCSKRYDEVAWSVVEKDTSIVLEKGNIERIPSLEDFPNNFYISPDGIINLTMVLPDNPSQEELSAAFKLAYYIGQQNKSKILWQVHTSSSYDASKAPGTVIALGRNDAAKQWNALKKYLLVSPEPDGGYHVADWLEVMPAALNSFDIYQIGKIDNDKLLYAFMYSSPERMNNLLNFSLLNENVLSGKLTLVDAQGNHASFAQSPAAAGTGSLAWLKSLWSYTDGVGQTYLAVFVAVLLATGALMFFMRKRS
>AP018449.1|BBB93519.1|4738746_4740738_-|hypothetical-protein
MRRRLSYLSTVCFLAVMSQPLQALAGSAVSVPAEARDTAAAAVAAAQDVLDKEEGARERAEATMYAQKAESELVEAQLQLTEAEKALAQSTLDAEEAAAEAQRAAKEAKAAADHAADLNKKAKEAIAEAEAAAAAAEAMEAALQAEEDAIMARQNVQTRPVLVETPVPGEPVQPNSFKDSDELLRMEKELKRLEKMQKDGDLARQGGIPVLEVSEEPNVDWSKAEAAYARAEQLEQGATDADKAAEQAGHIADQQTAYAEAVESKAAEAKQALLDAELLVKDAKASAEQAQKYAIQTKAQLEQLVYLQEHPKSVHTFVSELNYYSGNSAYQLTHPISFGYWHKDFSYSLNTKYIIAKNNTDGASGQVSTLSDTTLNFTKRNETPKYIVDYSLDINIPTGKSALSWSERNARMNEDLVAVSQFGTGWQFTPKIEASWRISKEDMWTVGTSYAFNGPYDPTTDISHDDISPGNEWRKFLRWQHAGRDWQFVGELSNTSTSVTKIANGEEYSTGDQWEYRLTYNRKLPNNQNIMLYYWRENQNINSIVPSDNSNRLAHYLGTMWSKKINEKRLLRVSFDIMKSNGRRYDRVNNYFDTDGNPQYTSVDVNGRTKYTLGLGYDIRLDEKSSFAIDLQKFIMKDGESSLGQAPTTYHGLNILMKYNKSI
>AP018449.1|BBB93518.1|4738159_4738261_-|hypothetical-protein
MMHCYRKYRKTVIAIFGMTMLTKKLLNFVSGFS
>AP018449.1|BBB93517.1|4736811_4738035_-|stage-II-sporulation-protein-E
MKNAELDTLEQLRIGIRLLAKGRYPDTIAAEGCSELVGEIVYLFNQVAGHFRELYEYAVPLTKGSLNVKRPDKTNFLAGSLKELHSRLNHLTWQAQQIEKGDYKQRVDLVGEFFQAFNSLVIKLEEREQRLKEEILVCQQAEAEVRAQNKLITDSIHYGAVIQQSILPELSFLENYIAESFVIWRPRDIVGGDFYWCAPCTDGFMAAVIDCTGHGVPGAFMTIAVNQMIKRLLDENANCQPADVLALLDKKIHETFYTHSGSKERLYVGLDMGLVKVNTTAHKVVFAGARLPLFFVHSGKIKEIPGSRRSIGYDQKSRLRKKLRIIQFENREFGYEPGDGLYLSTDGFFDQHGENPNPFSIDNFSKLITENFLLPMTEQRTALLQNLETYMGMEEQLDDITVMGLKF
>AP018449.1|BBB93527.1|4754782_4755094_-|CRISPR-associated-endoribonuclease-Cas2
MSGERCFVLLWMAGDIVYVILVYDVNEKRVGKVLKKCRQYLNWVQNSVLEGEISDANYTKLTMELNKIINNEEDSVIIYNLRTTKYSTRQILGHERASTSTII
>AP018449.1|BBB93528.1|4755090_4756083_-|CRISPR-associated-endonuclease-Cas1
MKKTLYFFSDGQLKRKDNTIFFENDSGRRFLPVEDVGDIMVFGEVDFNKKLLEFLSQKEIILHYFNHYGYYMGSFYPREHLNSGHAILKQAEYYLDEGKRLELAQNFVRGAARNIRQVLKYYHNRGKNVEKTLTAIEPLLESIDGCDTVPVLMAIEGNIREHYYRAFDEIIGDDNFCFEERTRRPPKNHLNTLISFGNSLMYSLCLSEIYKTHLDPRIGYLHSTNFRRFTLNLDVAEIFKPIIVDRIIFACLGRNMITKSDFERDMEGIVLREKGKKCFVEELEAKLKTTITHREIGRPVSYRRLIRLELYKLEKHLFGEKPYEPFVANW
>AP018449.1|BBB93529.1|4756110_4756611_-|hypothetical-protein
MDEIRIGGTLIWYYYVCPREAWLMGHNIVPDQENDNVAVGRYIAENSYQREKKEIVVGGSKIDVIHSEDGQMVIGEVKKSSKYRQSARMQLAFYLSELKERGITARGELRFPKEKVREEVVLDAGTEAELDKAKREILRILYLETSPLPKKISFCKNCAYAEYCWC
>AP018449.1|BBB93530.1|4756612_4757044_-|hypothetical-protein
MVDEGLVRQKLALLAEYLQDLREVEGVTTEEFVCDKRLRRYIERTLQVAVEACVDIASHWIADQGWREPASYRDIFVVLAENGVLSTEQAGVYQKMAQFRNILVHDYAKIEPEILLGILRRNLSDLEEFLKRIASLLHGGNWQ
>AP018449.1|BBB93531.1|4757033_4757462_-|nucleotidyltransferase-domain-protein
MQEKLESVFDYFRTHERVRVVWLFGSFAQGTARKDSDIDFAVLFEQSLSPEERFSLRLELMDKIEGLTNIRADVIDMESAPVFLQHQVRKTGRVVVEKDRERRIVFDVRSRREYFDFQPVLARRSAALLKKCGVKGGVVDGG
>AP018449.1|BBB93532.1|4759354_4761622_-|CRISPR-associated-endonuclease/helicase-Cas3
MSRVTEIAALLGSLLGEKRSHPGKKLIEHVLGVARLMEALSAEQGLNCDPEQIKAVALTHDIGKAHPEFQDYLEGKGEGVNHAKPSAWFTYTLLQDFWLAEVVCRHHTHLYSSKDLSKDWLPDSFSLPKQQKRMRQLVAGWPWLLSEEEYFDLEDTIMALGRDMAKSSDLDLWLRVRTLYSLLIAADRMEAIGVEQLLREPMPDFNQPIFPGRSAEVDAWRQNLQQTCLNQAREIAKPGVYTLTLPTGAGKTVTGLSVAYEWAKRFNCKSIIYALPFISIVEQTTNVAKAVFGDSAVQEDHSLAYGQEEKETEKRSPGVVAWRKVSALFRYWREPVVLTTMVQFWDAIFNSRANRTMNFHRLSNAVVILDEPQTIPPAYWRGLGDTLTYLSNKWGTFFLLMTATQPRIPAELELAPPQTFFPQVRHHYEYLPDKYPLEVLPELLAKNLPPQLSMRKNSGMVVVNTKKAALDVYRLFEAMNLEGPVLFLSGWVTPWRRQLTLKQLKKLEEDKALRYLVATQVVEAGVDVDFSWVFRDIGPLDSIIQVAGRCNRHLIGIVPGKVLIAELIGKNGRSLWNCVYSDVLVGRAKDVLQKQSVFDEKDVPAIVAEYYQRVETGLTPCDIAGNLAQGMWHDMPDLIDKSQRDTVTVFVEETDEVWPLLKKLQDQHWDLTRRDEKKRLLQQAQQYALEIPARQLRACELKCSAFYSTDGEPVFRQVFEGKAWFISKAAIRADGLYHPAIGFIPPEEDEGPQMW
>AP018449.1|BBB93533.1|4761572_4762289_-|CRISPR-associated-protein
MAIAFEVSGPVAMFRRPYTTTSSVSFPFPPPTAIAGVLTAVCGHSNGSGEEASAAKYWQYLRGTRVAISLLNPIAWYSATLNFWNVKNPQQSPHIQVKHQFVKNPRYRIYVEGGLETELQGYLEQEAFVYTPYLGVAYAISDIYYCGVFAWEPVTNDNIAIHSILPQPAEQSFKVDIVATGGLFKERVPFQMTADRALAKSMTVLYPTSPQRGIHLTAWEGLDVTRYGDSCIAWFPAW
>AP018449.1|BBB93534.1|4762294_4763203_-|hypothetical-protein
MVIEKRREILFVYSVRDANPNGDPLNANHPRYDAESGQILVSDVRIKRTLRDQWLREGLPVFIDGEAKTLKSRIEELKKEFGVETGKDALKRCLDARVFGVTYALDKESFSWIGPVQFKWGRSLHQAKAELVQGTAAFASKDNSEQRSFRNEYIVPFVLIGAYGIVNQFAAKETGATEDDANKISEGLWQGTVNLITRSKVGHVPRMLLEVTYKPDFTGAAGALDEKLRLVSLDGNELTTEEQLTIRKPQDCLLDANKIGARLTQLRENIATIKIWLDGELSVKGLDELQKTLGEKLSLQTR
>AP018449.1|BBB93535.1|4763237_4763654_-|hypothetical-protein
MNLDWLGDFSDPYLRTPLGQGVFLSGIILGVVAKGQVGNSGDIDSAPMFKQIMFGKMQRRDLLRHLARVPELLGAYDGLKKSAPYIRQLSGKTGELLLKGGGELGVEGNFAFSVAFLNARDYYWKIFGKSNDSEAAEE
>AP018449.1|BBB93536.1|4763650_4765177_-|CRISPR-associated-protein
MGFLQAVHALGVMAQKRSQGSVLADIMSFLQLPHPLGEAEAKRARVIRVWLKVANADSEILDVLSVDQIEPPAEYPAFSDEDKIKEMYLYRKPVGAAAQWSFSPLYKLGKGETEGKQALLGNNWQTDKDSRYYKIKRTVLNDFEVAGCFSAGGVERIMQGLVERADELAAFWTDRKRSYLLLFGVENNGVFLHPGQVPAFINYFRHKLTAPKEEQVKNSASSREKILRQCACCGSSAADVETLDKVFKFATFDKDSFLPGAKDGAGIKEKVFPVCPDCYALLSAGKTEMESRFVNTRIIPGINLYVLPEVCVGDMGATEIAAAETRDFFENGIAKESRVFRNLARKGTGLVYHFLFTELNNAQVKVHCLIEDVPPTRLNHLQSLWGETCTAFPMKNPAVDQDDDDGRINLDRAFRQIVSVMLSLAGKREQDKTVMREKALAMIGALLNNEVVELTGIKELMVSRFAGLFTDPDWLRPKGGEELSGLAKVRGMAEVVDFLIRVNGRREV

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Crispr_ID: AP018449_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018449_10

4757577-4758869

TypeIII

Consensus_repeat	Method
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CRISPRCasFinder
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CRT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	PILER-CR

19 spacers

cas4,cas1,cas2,cas3,cas5,cas7,cas8b1,cas6

The CRISPR arrays of AP018449_10

>merge|AP018449|10|4757577-4758869|CRISPRCasFinder,CRT,PILER-CR
GTTTCAATCCCTTATAAGTAACCTACAAACTTTACTATCCCTTATTATACCTGGGGCAAAACATTGTTTCAATCCCTTATAGGTAGGCTACAAACTTACATAATCGACAACAACCGGGTAACCGGAACCAGGTTTCAATCCCTTATAGGTAGGCTACAAACGGTCAGTGTTAACGAAACCACTCATACGGTCCGGGGTTTCAATCCCTTATAGGTAGGCTACAAACCAATCCCCTGCAGCCATGTTTCAGGCTCAACACGCTGGTTTCAATCCCTTATAGGTAGGCTACAAACAATCCTTCGTGTTGGTAGGGATGTTCCCAGGATTTGGTTTCAATCCCTTATAGGTAGGCTACAAACCAAGCTCGTTCCAAGCCTGGCGGCCGGGTGCTGTCATCGGTTTCAATCCCTTATAGGTAGGCTACAAACGTGCTCTTGTCATTTTCATCTCTCCCTGTTCTTTTATGTTTCAATCCCTTATAGGTAGGCTACAAACAAAAAAAATATTGACAACCAAAATGATCCCAAGCTAGTTTCAATCCCTTATAGGTAGGCTACAAACAGCTGGTGAGTATATAGGTTTTCACCCGTCATATGATTGTTTCAATCCCTTATAGGTAGGCTACAAACCTACTTCAGTATCAGTTAACACCCCATTATAAACCCGTTTCAATCCCTTATAGGTAGGCTACAAACTCCACCGCTATCTGGAGTTTCGTGACCGCCTGCAGGGTTTCAATCCCTTATAGGTAGGCTACAAACGCCCAAGTGATACGCGAGCATGGATATCCGGTGATCAGGTTTCAATCCCTTATAGGTAGGCTACAAACTGACCGACAACTTGTCCGTCACAAATATCCATATTCTGGTTTCAATCCCTTATAGGTAGGCTACAAACTGCGTATAGTAAAGTCATGAGGTGATATATTGGTGAAGTTTCAATCCCTTATAGGTAGGCTACAAACTTTACGTCTTTACTCCAGGCCTGCAGTTGATCGGCAAGTTTCAATCCCTTATAGGTAGGCTACAAACTCTTCAGACAATTGGCTAGCAGCATACCGATTATGGGTTTCAATCCCTTATAGGTAGGCTACAAACGGGTGGCGGTTTTCCGCCGGCGAATGTGACTATGGTTTCAATCCCTTATAGGTAGGCTACAAACCTTGCCGTCATCGCCAAGTATCAGCTTAGAACGATGTTTCAATCCCTTATAGGTAGGCTACAAACCCGAAGGGTTGCAATATCTGCACAAAGACCCCAAAGGGTTTCAATCCCTTATAGGTAGGCTACAAAC

>AP018449|10|10|4757577-4758869|CRISPRCasFinder
GTTTCAATCCCTTATAAGTAACCTACAAAC	TTTACTATCCCTTATTATACCTGGGGCAAAACATT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TTACATAATCGACAACAACCGGGTAACCGGAACCAG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GGTCAGTGTTAACGAAACCACTCATACGGTCCGGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CAATCCCCTGCAGCCATGTTTCAGGCTCAACACGCTG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	AATCCTTCGTGTTGGTAGGGATGTTCCCAGGATTTG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CAAGCTCGTTCCAAGCCTGGCGGCCGGGTGCTGTCATCG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GTGCTCTTGTCATTTTCATCTCTCCCTGTTCTTTTAT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	AAAAAAAATATTGACAACCAAAATGATCCCAAGCTA
GTTTCAATCCCTTATAGGTAGGCTACAAAC	AGCTGGTGAGTATATAGGTTTTCACCCGTCATATGATT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CTACTTCAGTATCAGTTAACACCCCATTATAAACCC
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TCCACCGCTATCTGGAGTTTCGTGACCGCCTGCAGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GCCCAAGTGATACGCGAGCATGGATATCCGGTGATCAG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TGACCGACAACTTGTCCGTCACAAATATCCATATTCTG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TGCGTATAGTAAAGTCATGAGGTGATATATTGGTGAA
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TTTACGTCTTTACTCCAGGCCTGCAGTTGATCGGCAA
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TCTTCAGACAATTGGCTAGCAGCATACCGATTATGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GGGTGGCGGTTTTCCGCCGGCGAATGTGACTATG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CTTGCCGTCATCGCCAAGTATCAGCTTAGAACGAT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CCGAAGGGTTGCAATATCTGCACAAAGACCCCAAAGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC

>AP018449|10|8|4757577-4758869|CRT
GTTTCAATCCCTTATAAGTAACCTACAAAC	TTTACTATCCCTTATTATACCTGGGGCAAAACATT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TTACATAATCGACAACAACCGGGTAACCGGAACCAG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GGTCAGTGTTAACGAAACCACTCATACGGTCCGGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CAATCCCCTGCAGCCATGTTTCAGGCTCAACACGCTG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	AATCCTTCGTGTTGGTAGGGATGTTCCCAGGATTTG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CAAGCTCGTTCCAAGCCTGGCGGCCGGGTGCTGTCATCG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GTGCTCTTGTCATTTTCATCTCTCCCTGTTCTTTTAT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	AAAAAAAATATTGACAACCAAAATGATCCCAAGCTA
GTTTCAATCCCTTATAGGTAGGCTACAAAC	AGCTGGTGAGTATATAGGTTTTCACCCGTCATATGATT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CTACTTCAGTATCAGTTAACACCCCATTATAAACCC
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TCCACCGCTATCTGGAGTTTCGTGACCGCCTGCAGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GCCCAAGTGATACGCGAGCATGGATATCCGGTGATCAG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TGACCGACAACTTGTCCGTCACAAATATCCATATTCTG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TGCGTATAGTAAAGTCATGAGGTGATATATTGGTGAA
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TTTACGTCTTTACTCCAGGCCTGCAGTTGATCGGCAA
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TCTTCAGACAATTGGCTAGCAGCATACCGATTATGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GGGTGGCGGTTTTCCGCCGGCGAATGTGACTATG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CTTGCCGTCATCGCCAAGTATCAGCTTAGAACGAT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CCGAAGGGTTGCAATATCTGCACAAAGACCCCAAAGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC

>AP018449|10|8|4757642-4758869|PILER-CR
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TTACATAATCGACAACAACCGGGTAACCGGAACCAG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GGTCAGTGTTAACGAAACCACTCATACGGTCCGGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CAATCCCCTGCAGCCATGTTTCAGGCTCAACACGCTG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	AATCCTTCGTGTTGGTAGGGATGTTCCCAGGATTTG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CAAGCTCGTTCCAAGCCTGGCGGCCGGGTGCTGTCATCG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GTGCTCTTGTCATTTTCATCTCTCCCTGTTCTTTTAT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	AAAAAAAATATTGACAACCAAAATGATCCCAAGCTA
GTTTCAATCCCTTATAGGTAGGCTACAAAC	AGCTGGTGAGTATATAGGTTTTCACCCGTCATATGATT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CTACTTCAGTATCAGTTAACACCCCATTATAAACCC
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TCCACCGCTATCTGGAGTTTCGTGACCGCCTGCAGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GCCCAAGTGATACGCGAGCATGGATATCCGGTGATCAG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TGACCGACAACTTGTCCGTCACAAATATCCATATTCTG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TGCGTATAGTAAAGTCATGAGGTGATATATTGGTGAA
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TTTACGTCTTTACTCCAGGCCTGCAGTTGATCGGCAA
GTTTCAATCCCTTATAGGTAGGCTACAAAC	TCTTCAGACAATTGGCTAGCAGCATACCGATTATGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	GGGTGGCGGTTTTCCGCCGGCGAATGTGACTATG
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CTTGCCGTCATCGCCAAGTATCAGCTTAGAACGAT
GTTTCAATCCCTTATAGGTAGGCTACAAAC	CCGAAGGGTTGCAATATCTGCACAAAGACCCCAAAGG
GTTTCAATCCCTTATAGGTAGGCTACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
AP018449.1\|BBB93536.1\|4763650_4765177_-\|CRISPR-associated-protein	cas8b1	cd09730_cas8b1_CAS-I-B	gnl\|CDD\|378190
AP018449.1\|BBB93538.1\|4766160_4766508_-\|mRNA-interferase-EndoA	unknown	unknown	gnl\|CDD\|367091
AP018449.1\|BBB93532.1\|4759354_4761622_-\|CRISPR-associated-endonuclease/helicase-Cas3	cas3	COG1203_cas3_CAS-I	gnl\|CDD\|224124
AP018449.1\|BBB93527.1\|4754782_4755094_-\|CRISPR-associated-endoribonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
AP018449.1\|BBB93534.1\|4762294_4763203_-\|hypothetical-protein	cas7	cd09690_cas7_CAS-I-B	gnl\|CDD\|274217
AP018449.1\|BBB93540.1\|4767255_4767447_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93541.1\|4767506_4767785_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93524.1\|4746583_4747717_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93539.1\|4766501_4766756_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223932
AP018449.1\|BBB93529.1\|4756110_4756611_-\|hypothetical-protein	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
AP018449.1\|BBB93530.1\|4756612_4757044_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|366864
AP018449.1\|BBB93526.1\|4751404_4751695_-\|sirohydrochlorin-cobaltochelatase	unknown	unknown	gnl\|CDD\|368778
AP018449.1\|BBB93537.1\|4765190_4765925_-\|CRISPR-associated-protein-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
AP018449.1\|BBB93528.1\|4755090_4756083_-\|CRISPR-associated-endonuclease-Cas1	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|274695
AP018449.1\|BBB93531.1\|4757033_4757462_-\|nucleotidyltransferase-domain-protein	unknown	unknown	gnl\|CDD\|376187
AP018449.1\|BBB93535.1\|4763237_4763654_-\|hypothetical-protein	cas8b1	mkCas0119_cas8b1_CAS-I-B	gnl\|CDD\|378190
AP018449.1\|BBB93533.1\|4761572_4762289_-\|CRISPR-associated-protein	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
AP018449.1\|BBB93522.1\|4744118_4745747_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|200549
AP018449.1\|BBB93525.1\|4750886_4751363_-\|sirohydrochlorin-cobaltochelatase-CbiKP-precursor	unknown	unknown	gnl\|CDD\|368778
AP018449.1\|BBB93523.1\|4745733_4746597_-\|putative-diguanylate-cyclase-AdrA	unknown	unknown	gnl\|CDD\|143635

Protein	Function_ID	Function_description	E-value
AP018449.1\|BBB93536.1\|4763650_4765177_-\|CRISPR-associated-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	6.0826e-23
AP018449.1\|BBB93538.1\|4766160_4766508_-\|mRNA-interferase-EndoA	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	1.71313e-26
AP018449.1\|BBB93532.1\|4759354_4761622_-\|CRISPR-associated-endonuclease/helicase-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	4.70822e-45
AP018449.1\|BBB93527.1\|4754782_4755094_-\|CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.67459e-32
AP018449.1\|BBB93534.1\|4762294_4763203_-\|hypothetical-protein	gnl\|CDD\|274217	TIGR02590, hypothetical_protein_MM_0563, CRISPR-associated protein Cas7/Csh2, subtype I-B/HMARI. This model represents one of two closely related CRISPR-associated proteins that belong to the larger family of TIGR01595. Members are the Csh2 protein of the Hmari subtype of CRISPR/cas system. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. The related model is TIGR02589, the Csd3 protein of the Dvulg CRISPR subtype.	1.40396e-76
AP018449.1\|BBB93539.1\|4766501_4766756_-\|hypothetical-protein	gnl\|CDD\|223932	COG0864, NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription].	0.000357602
AP018449.1\|BBB93529.1\|4756110_4756611_-\|hypothetical-protein	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	7.71176e-70
AP018449.1\|BBB93530.1\|4756612_4757044_-\|hypothetical-protein	gnl\|CDD\|366864	pfam01934, DUF86, Protein of unknown function DUF86. The function of members of this family is unknown.	3.40464e-35
AP018449.1\|BBB93526.1\|4751404_4751695_-\|sirohydrochlorin-cobaltochelatase	gnl\|CDD\|368778	pfam06180, CbiK, Cobalt chelatase (CbiK). This family consists of several bacterial cobalt chelatase (CbiK) proteins (EC:4.99.1.-).	2.13884e-26
AP018449.1\|BBB93537.1\|4765190_4765925_-\|CRISPR-associated-protein-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	4.36071e-38
AP018449.1\|BBB93528.1\|4755090_4756083_-\|CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|274695	TIGR03641, cas1_HMARI, CRISPR-associated endonuclease Cas1, subtype I-B/HMARI/TNEAP. The CRISPR-associated protein Cas1 is virtually universal to CRISPR systems. CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is prokaryotic immunity system for foreign DNA, mostly from phage. CRISPR systems belong to different subtypes, distinguished by both nature of the repeats, the makeup of the cohort of associated Cas proteins, and by molecular phylogeny within the more universal Cas proteins such as this one. This model is of type EXCEPTION and provides more specific information than the EQUIVALOG model TIGR00287. It describes Cas1 subgroup that includes Cas1 proteins of the related HMARI and TNEAP subtypes of CRISPR/Cas system.	3.30429e-176
AP018449.1\|BBB93531.1\|4757033_4757462_-\|nucleotidyltransferase-domain-protein	gnl\|CDD\|376187	pfam18765, Polbeta, Polymerase beta, Nucleotidyltransferase. A member of the nucleotidyltransferase fold found in polymorphic toxins (NTox45) and polyvalent proteins.	2.39204e-28
AP018449.1\|BBB93535.1\|4763237_4763654_-\|hypothetical-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	1.83152e-08
AP018449.1\|BBB93533.1\|4761572_4762289_-\|CRISPR-associated-protein	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.63382e-31
AP018449.1\|BBB93522.1\|4744118_4745747_-\|hypothetical-protein	gnl\|CDD\|200549	cd10923, CE4_COG5298, Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria. This family corresponds to a group of uncharacterized bacterial proteins with high sequence similarity to the catalytic domain of the six-stranded barrel rhizobial NodB-like proteins, which remove N-linked or O-linked acetyl groups from cell wall polysaccharides and belong to the larger carbohydrate esterase 4 (CE4) superfamily. Some family members contain an additional copper amine oxidase N-terminal domain.	3.29695e-70
AP018449.1\|BBB93525.1\|4750886_4751363_-\|sirohydrochlorin-cobaltochelatase-CbiKP-precursor	gnl\|CDD\|368778	pfam06180, CbiK, Cobalt chelatase (CbiK). This family consists of several bacterial cobalt chelatase (CbiK) proteins (EC:4.99.1.-).	2.91907e-55
AP018449.1\|BBB93523.1\|4745733_4746597_-\|putative-diguanylate-cyclase-AdrA	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	5.35191e-17

>AP018449.1|BBB93531.1|4757033_4757462_-|nucleotidyltransferase-domain-protein
MQEKLESVFDYFRTHERVRVVWLFGSFAQGTARKDSDIDFAVLFEQSLSPEERFSLRLELMDKIEGLTNIRADVIDMESAPVFLQHQVRKTGRVVVEKDRERRIVFDVRSRREYFDFQPVLARRSAALLKKCGVKGGVVDGG
>AP018449.1|BBB93530.1|4756612_4757044_-|hypothetical-protein
MVDEGLVRQKLALLAEYLQDLREVEGVTTEEFVCDKRLRRYIERTLQVAVEACVDIASHWIADQGWREPASYRDIFVVLAENGVLSTEQAGVYQKMAQFRNILVHDYAKIEPEILLGILRRNLSDLEEFLKRIASLLHGGNWQ
>AP018449.1|BBB93529.1|4756110_4756611_-|hypothetical-protein
MDEIRIGGTLIWYYYVCPREAWLMGHNIVPDQENDNVAVGRYIAENSYQREKKEIVVGGSKIDVIHSEDGQMVIGEVKKSSKYRQSARMQLAFYLSELKERGITARGELRFPKEKVREEVVLDAGTEAELDKAKREILRILYLETSPLPKKISFCKNCAYAEYCWC
>AP018449.1|BBB93528.1|4755090_4756083_-|CRISPR-associated-endonuclease-Cas1
MKKTLYFFSDGQLKRKDNTIFFENDSGRRFLPVEDVGDIMVFGEVDFNKKLLEFLSQKEIILHYFNHYGYYMGSFYPREHLNSGHAILKQAEYYLDEGKRLELAQNFVRGAARNIRQVLKYYHNRGKNVEKTLTAIEPLLESIDGCDTVPVLMAIEGNIREHYYRAFDEIIGDDNFCFEERTRRPPKNHLNTLISFGNSLMYSLCLSEIYKTHLDPRIGYLHSTNFRRFTLNLDVAEIFKPIIVDRIIFACLGRNMITKSDFERDMEGIVLREKGKKCFVEELEAKLKTTITHREIGRPVSYRRLIRLELYKLEKHLFGEKPYEPFVANW
>AP018449.1|BBB93527.1|4754782_4755094_-|CRISPR-associated-endoribonuclease-Cas2
MSGERCFVLLWMAGDIVYVILVYDVNEKRVGKVLKKCRQYLNWVQNSVLEGEISDANYTKLTMELNKIINNEEDSVIIYNLRTTKYSTRQILGHERASTSTII
>AP018449.1|BBB93526.1|4751404_4751695_-|sirohydrochlorin-cobaltochelatase
MKGKTILAVSFGTTYPETLKLTIESVESKIKQSFPEFEVRRAFTSRMVIKRIFERDGIRIDTEIEALERLRIEGYQEYTFSRFILLPVKNMKRLKE
>AP018449.1|BBB93525.1|4750886_4751363_-|sirohydrochlorin-cobaltochelatase-CbiKP-precursor
MGRPILFYGGEEGKPDDYLIAINAIRNLFPALSAGEAAVLMGHGGLHPANAAYGALQVKLADAGLENVFVYTVEGFPSLAEVIKKLKTDNIKKVVLIPFMLVAGAHVMNDMIGDDKDSARSQVVSAGIEVRAYLQGMGENAAIQDIYIQHLKDIIDED
>AP018449.1|BBB93524.1|4746583_4747717_-|hypothetical-protein
MKIRIALLVFLVVLAVMVQFIFLNNTPNPNLTEAKVNQNPAAGKNPKPEEIQAFRFLRTRMQSPHGVIRYLVDAKSPAAFGVSESMGQAMEYTALLGDAKLFGKYAAFTDKYFKDPTGYYYWKIDVASKKGETTSALVDDLRIVKAYFIANEKKLGNYDKQIEKLAEAIYEFDVDAKGYPCDFYDGIAKKKADIVSLFYLDVETMEKLSKVNAKWSASHKNAIRILLNMPENQHGFYPQTFKIDTKQYIWPISINMVENLYTAIDAYNAGKSTSALVTFLKAQVKQGKVYNHYNSDGTPVNQDESTAVYALSTRFLALNNEWEAAEWCYHRTLDFQINDKKSFEGGFGEPETGLVYAFDQLEALLMLRMVEIKNDSQ
>AP018449.1|BBB93523.1|4745733_4746597_-|putative-diguanylate-cyclase-AdrA
MIASDKYIRKDILFFNLIMVFILAVIAIVLLYAPTMGTFNLFIPFACLLFNMIVSHNLGLQRGLMAGIVLTFAFGSYIIYETMIINRITEVNFAYIAWLFFFPLSSILAGQLSLVVSNYRRELENKKSLEQLVTIDASTGLYNSQGFFRKLEEEFVRAKRYKTCFSILLIKMSNFDELQVIYGEIDSIKILQSVAGKVELQTRFSDIKALISADILGIMLPETNEDGARIVIEKLHQALDRLTTEIRGTKKVIRIKPSIGISSIKESDTDVLEAYQRAKEELNYDRG
>AP018449.1|BBB93522.1|4744118_4745747_-|hypothetical-protein
MIEVRKKAIMFFLLAIFTFGICLPTSSYSSAPKLKTYIVYDSPNRFADSFPLVNALIEHLGHFDLACQPMALQEWKPGALQDAELIVYAGLSDVTLPQGLLQEMAHARRVIWFEKNIEQMAAYLHWQDFKLEGVFNGWSFINYKRDVFIDDWINVVIAQPGQNAQVFATVKDIVASKPLAWQRDNVYYCGLLEVHPKYMITLSGLLHQFIPNQNHNHSHSHKALLRIEDVSPLVNSEAVGAVIATITKYNIPFSIGVIPVGVTKDDRYIFLHERPNLLKVLKEAQDNGASIIMHGYTHQNKYSPKTGEGYEFWNARDDKPMENDDAFTSERIEAGIEELVRCGLTPVAFEPPHYAMSEAGYKVLSRYFNIFSGQIQISDKSDRLSLSLPYVTTSTYLNGMMVIPENMGYYDGKTFLVDHMLQSSEQILEIQDGFACFFYHGYLPPDKLPSIIEGLQKQGYEFYDLRQLPILVHSPKIKIIGRDGQLRVEVDAKLQSSWGSNPVDDNMFKKIGSVHITLLLLILGIFVVIIIRLRANANKHYE
>AP018449.1|BBB93532.1|4759354_4761622_-|CRISPR-associated-endonuclease/helicase-Cas3
MSRVTEIAALLGSLLGEKRSHPGKKLIEHVLGVARLMEALSAEQGLNCDPEQIKAVALTHDIGKAHPEFQDYLEGKGEGVNHAKPSAWFTYTLLQDFWLAEVVCRHHTHLYSSKDLSKDWLPDSFSLPKQQKRMRQLVAGWPWLLSEEEYFDLEDTIMALGRDMAKSSDLDLWLRVRTLYSLLIAADRMEAIGVEQLLREPMPDFNQPIFPGRSAEVDAWRQNLQQTCLNQAREIAKPGVYTLTLPTGAGKTVTGLSVAYEWAKRFNCKSIIYALPFISIVEQTTNVAKAVFGDSAVQEDHSLAYGQEEKETEKRSPGVVAWRKVSALFRYWREPVVLTTMVQFWDAIFNSRANRTMNFHRLSNAVVILDEPQTIPPAYWRGLGDTLTYLSNKWGTFFLLMTATQPRIPAELELAPPQTFFPQVRHHYEYLPDKYPLEVLPELLAKNLPPQLSMRKNSGMVVVNTKKAALDVYRLFEAMNLEGPVLFLSGWVTPWRRQLTLKQLKKLEEDKALRYLVATQVVEAGVDVDFSWVFRDIGPLDSIIQVAGRCNRHLIGIVPGKVLIAELIGKNGRSLWNCVYSDVLVGRAKDVLQKQSVFDEKDVPAIVAEYYQRVETGLTPCDIAGNLAQGMWHDMPDLIDKSQRDTVTVFVEETDEVWPLLKKLQDQHWDLTRRDEKKRLLQQAQQYALEIPARQLRACELKCSAFYSTDGEPVFRQVFEGKAWFISKAAIRADGLYHPAIGFIPPEEDEGPQMW
>AP018449.1|BBB93533.1|4761572_4762289_-|CRISPR-associated-protein
MAIAFEVSGPVAMFRRPYTTTSSVSFPFPPPTAIAGVLTAVCGHSNGSGEEASAAKYWQYLRGTRVAISLLNPIAWYSATLNFWNVKNPQQSPHIQVKHQFVKNPRYRIYVEGGLETELQGYLEQEAFVYTPYLGVAYAISDIYYCGVFAWEPVTNDNIAIHSILPQPAEQSFKVDIVATGGLFKERVPFQMTADRALAKSMTVLYPTSPQRGIHLTAWEGLDVTRYGDSCIAWFPAW
>AP018449.1|BBB93534.1|4762294_4763203_-|hypothetical-protein
MVIEKRREILFVYSVRDANPNGDPLNANHPRYDAESGQILVSDVRIKRTLRDQWLREGLPVFIDGEAKTLKSRIEELKKEFGVETGKDALKRCLDARVFGVTYALDKESFSWIGPVQFKWGRSLHQAKAELVQGTAAFASKDNSEQRSFRNEYIVPFVLIGAYGIVNQFAAKETGATEDDANKISEGLWQGTVNLITRSKVGHVPRMLLEVTYKPDFTGAAGALDEKLRLVSLDGNELTTEEQLTIRKPQDCLLDANKIGARLTQLRENIATIKIWLDGELSVKGLDELQKTLGEKLSLQTR
>AP018449.1|BBB93535.1|4763237_4763654_-|hypothetical-protein
MNLDWLGDFSDPYLRTPLGQGVFLSGIILGVVAKGQVGNSGDIDSAPMFKQIMFGKMQRRDLLRHLARVPELLGAYDGLKKSAPYIRQLSGKTGELLLKGGGELGVEGNFAFSVAFLNARDYYWKIFGKSNDSEAAEE
>AP018449.1|BBB93536.1|4763650_4765177_-|CRISPR-associated-protein
MGFLQAVHALGVMAQKRSQGSVLADIMSFLQLPHPLGEAEAKRARVIRVWLKVANADSEILDVLSVDQIEPPAEYPAFSDEDKIKEMYLYRKPVGAAAQWSFSPLYKLGKGETEGKQALLGNNWQTDKDSRYYKIKRTVLNDFEVAGCFSAGGVERIMQGLVERADELAAFWTDRKRSYLLLFGVENNGVFLHPGQVPAFINYFRHKLTAPKEEQVKNSASSREKILRQCACCGSSAADVETLDKVFKFATFDKDSFLPGAKDGAGIKEKVFPVCPDCYALLSAGKTEMESRFVNTRIIPGINLYVLPEVCVGDMGATEIAAAETRDFFENGIAKESRVFRNLARKGTGLVYHFLFTELNNAQVKVHCLIEDVPPTRLNHLQSLWGETCTAFPMKNPAVDQDDDDGRINLDRAFRQIVSVMLSLAGKREQDKTVMREKALAMIGALLNNEVVELTGIKELMVSRFAGLFTDPDWLRPKGGEELSGLAKVRGMAEVVDFLIRVNGRREV
>AP018449.1|BBB93537.1|4765190_4765925_-|CRISPR-associated-protein-Cas6
MQIVLRLNAANGLTLPIDYNHIVQSAIYHSIAPALATFLHEQGFTANGRVFRLFCFSRLLGPFTMDRNSGKITFGNDVRLVISSPVVDFVQSLANGLLQQGGWRLGSTFADITEIGAEQPVVESENINIRTLSPVTAYSTMSRPDGRKYTVYFQPGDPDYNALITANLQKKYQAFFREEPPEGEVKVKAAGQIKMNLLQYKGTVIKGYSGPLQLTGPQELLQMAVDCGLGSKNSQGFGCLALSN
>AP018449.1|BBB93538.1|4766160_4766508_-|mRNA-interferase-EndoA
MVIKKWTIYWVNLDPVVGSEQGGTRPVLLVSDDAVNVLNQVSILPITSLKDPNREIYPNEAFLPKAVSGLDKDSIVLAHQIRTLDKQRLQSVAGPIQEAETKAAIEAAMRVQLGL
>AP018449.1|BBB93539.1|4766501_4766756_-|hypothetical-protein
MNKNVTFSLPAELMDNIRKLVEEGYKTSINNLVREALEMYLKEVQQVQIREAMLRAAKDPLFQADVGECEFDFRHVDKECSIEW
>AP018449.1|BBB93540.1|4767255_4767447_-|hypothetical-protein
MTPIWYVCDGEVETYSGQEADWKCSAVVIAPSPEEALIKVMQYHQQIINHVEVFHNGKTVVAI
>AP018449.1|BBB93541.1|4767506_4767785_-|hypothetical-protein
MNVFAMISKEIFDEITEKADLSTNNPAYAESSEKLSQLYQKLQETLLEEFRKDQVELDSRYGARQAASGRGYFGLGFAAGIRFIIQCLQGRM

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Crispr_ID: AP018449_11

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

AP018449_11

4769382-4771016

TypeIII

Consensus_repeat	Method
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CRISPRCasFinder
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CRT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	PILER-CR

24 spacers

cas6,cas8b1,cas7,cas5,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10

The CRISPR arrays of AP018449_11

>merge|AP018449|11|4769382-4771016|CRISPRCasFinder,CRT,PILER-CR
CGTTCAATCCCTTATAGGTAACCTACACAAACGGAGGGTGATTCCCCCGCTGCAGTTGACTTTTTTTATGTTTCAATCCCTTATAGGTAAGCTACAAACTCGAGCAAAAAACCCTGCACTTCCCCCGTCACCCGGCGTTTCAATCCCTTATAGGTAAGCTACAAACCAAAAGCGTCTGCAACTCCCGGCGCAGTGGCGAATTGAGTTTCAATCCCTTATAGGTAAGCTACAAACCTTGGCGTCACAGCCGAGAACCAAGAGCAGGCTGACAGTTTCAATCCCTTATAGGTAAGCTACAAACACGCGCCCGAACCGCTGACAGGCGCACCGTCGTCGACGAGTTTCAATCCCTTATAGGTAAGCTACAAACAGATTCTCCACTGTTTTTCAAACAAACTTCAAACTTGAGTTTCAATCCCTTATAGGTAAGCTACAAACTAATTATGTCGCAAGGTTGGCGCGCACCAATCACTGGTTTCAATCCCTTATAGGTAAGCTACAAACAGGGAATACGGAGGCCGATAGAGGGTACTTATATGCCGGGTTTCAATCCCTTATAGGTAAGCTACAAACCCTGATGAGTTTATTGAAAGGTTAGTACATGCGGTGTTTCAATCCCTTATAGGTAAGCTACAAACAAATTCGGATCAGGTTTTATTCGGGCATTCACATACGCGTTTCAATCCCTTATAGGTAAGCTACAAACAGTCCACGTGGTCCAGAATGAACTTTACCCCAGCTGAGTTTCAATCCCTTATAGGTAAGCTACAAACCAAAAAGCACTGCCATGGCGGGAGAGGGAAAGACCGCAGTTTCAATCCCTTATAGGTAAGCTACAAACGTGGTGACTATCTTGCCTTTTCTGATGGCACAGTTTGTTTCAATCCCTTATAGGTAAGCTACAAACTGCTGGCATCCCTGTGATTTTCCCTGAGCTAGGTTGGTTTCAATCCCTTATAGGTAAGCTACAAACTGTAGTCGGCCAGCGGCACCAGTAGCCAGGAAAGGATGTTTCAATCCCTTATAGGTAAGCTACAAACATTTTGATTTTCCAGGGAACACCGGCAAACATGGCTGGTTTCAATCCCTTATAGGTAAGCTACAAACTGGCGGCGCATTAACTCAGGTGGCGAACAAATTTATGTTTCAATCCCTTATAGGTAAGCTACAAACCATACGTGGCCAGGCAGCAATGCCGACAGCTTATTTGTTTCAATCCCTTATAGGTAAGCTACAAACCTTGGTTAAAGAAGGCGTTTTAGTTTTGATACCTTAGTTTCAATCCCTTATAGGTAAGCTACAAACTGGAGAGCTTTCTTGCCGGTGAAGCCCATTGCCAGGTTTCAATCCCTTATAGGTAAGCTACAAACTGAGATGGGGCATCAACGCTTTTGAATCTCCATTATCGTTTCAATCCCTTATAGGTAAGCTACAAACCTGCTTTTTTAATCGGCTTGCGTGCTACGGAGAGCCCGTTTCAATCCCTTATAGGTAAGCTACAAACATTTACGCCTCCGGTCGCTCACAACACGCAGTCAAGTTTCAATCCCTTATAGGTAAGCTACAAACGTTTTTTGGCCGATCTAAAAGAGTATGTGAAAATAAGTTTCAATCCCTTATAGGTAAGCTACAAAC

>AP018449|11|11|4769382-4771016|CRISPRCasFinder
CGTTCAATCCCTTATAGGTAACCTACACAA	ACGGAGGGTGATTCCCCCGCTGCAGTTGACTTTTTTTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TCGAGCAAAAAACCCTGCACTTCCCCCGTCACCCGGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAAAAGCGTCTGCAACTCCCGGCGCAGTGGCGAATTGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTTGGCGTCACAGCCGAGAACCAAGAGCAGGCTGACA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ACGCGCCCGAACCGCTGACAGGCGCACCGTCGTCGACGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGATTCTCCACTGTTTTTCAAACAAACTTCAAACTTGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAATTATGTCGCAAGGTTGGCGCGCACCAATCACTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGGGAATACGGAGGCCGATAGAGGGTACTTATATGCCGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CCTGATGAGTTTATTGAAAGGTTAGTACATGCGGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAATTCGGATCAGGTTTTATTCGGGCATTCACATACGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTCCACGTGGTCCAGAATGAACTTTACCCCAGCTGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAAAAAGCACTGCCATGGCGGGAGAGGGAAAGACCGCA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTGGTGACTATCTTGCCTTTTCTGATGGCACAGTTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGCTGGCATCCCTGTGATTTTCCCTGAGCTAGGTTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGTAGTCGGCCAGCGGCACCAGTAGCCAGGAAAGGAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTTTGATTTTCCAGGGAACACCGGCAAACATGGCTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGGCGGCGCATTAACTCAGGTGGCGAACAAATTTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATACGTGGCCAGGCAGCAATGCCGACAGCTTATTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTTGGTTAAAGAAGGCGTTTTAGTTTTGATACCTTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGGAGAGCTTTCTTGCCGGTGAAGCCCATTGCCAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGAGATGGGGCATCAACGCTTTTGAATCTCCATTATC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTGCTTTTTTAATCGGCTTGCGTGCTACGGAGAGCCC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTTACGCCTCCGGTCGCTCACAACACGCAGTCAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTTTTTTGGCCGATCTAAAAGAGTATGTGAAAATAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC

>AP018449|11|9|4769382-4771016|CRT
CGTTCAATCCCTTATAGGTAACCTACACAA	ACGGAGGGTGATTCCCCCGCTGCAGTTGACTTTTTTTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TCGAGCAAAAAACCCTGCACTTCCCCCGTCACCCGGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAAAAGCGTCTGCAACTCCCGGCGCAGTGGCGAATTGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTTGGCGTCACAGCCGAGAACCAAGAGCAGGCTGACA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ACGCGCCCGAACCGCTGACAGGCGCACCGTCGTCGACGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGATTCTCCACTGTTTTTCAAACAAACTTCAAACTTGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAATTATGTCGCAAGGTTGGCGCGCACCAATCACTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGGGAATACGGAGGCCGATAGAGGGTACTTATATGCCGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CCTGATGAGTTTATTGAAAGGTTAGTACATGCGGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAATTCGGATCAGGTTTTATTCGGGCATTCACATACGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTCCACGTGGTCCAGAATGAACTTTACCCCAGCTGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAAAAAGCACTGCCATGGCGGGAGAGGGAAAGACCGCA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTGGTGACTATCTTGCCTTTTCTGATGGCACAGTTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGCTGGCATCCCTGTGATTTTCCCTGAGCTAGGTTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGTAGTCGGCCAGCGGCACCAGTAGCCAGGAAAGGAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTTTGATTTTCCAGGGAACACCGGCAAACATGGCTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGGCGGCGCATTAACTCAGGTGGCGAACAAATTTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATACGTGGCCAGGCAGCAATGCCGACAGCTTATTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTTGGTTAAAGAAGGCGTTTTAGTTTTGATACCTTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGGAGAGCTTTCTTGCCGGTGAAGCCCATTGCCAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGAGATGGGGCATCAACGCTTTTGAATCTCCATTATC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTGCTTTTTTAATCGGCTTGCGTGCTACGGAGAGCCC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTTACGCCTCCGGTCGCTCACAACACGCAGTCAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTTTTTTGGCCGATCTAAAAGAGTATGTGAAAATAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC

>AP018449|11|9|4769451-4771016|PILER-CR
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TCGAGCAAAAAACCCTGCACTTCCCCCGTCACCCGGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAAAAGCGTCTGCAACTCCCGGCGCAGTGGCGAATTGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTTGGCGTCACAGCCGAGAACCAAGAGCAGGCTGACA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ACGCGCCCGAACCGCTGACAGGCGCACCGTCGTCGACGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGATTCTCCACTGTTTTTCAAACAAACTTCAAACTTGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TAATTATGTCGCAAGGTTGGCGCGCACCAATCACTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGGGAATACGGAGGCCGATAGAGGGTACTTATATGCCGG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CCTGATGAGTTTATTGAAAGGTTAGTACATGCGGT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AAATTCGGATCAGGTTTTATTCGGGCATTCACATACGC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	AGTCCACGTGGTCCAGAATGAACTTTACCCCAGCTGA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CAAAAAGCACTGCCATGGCGGGAGAGGGAAAGACCGCA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTGGTGACTATCTTGCCTTTTCTGATGGCACAGTTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGCTGGCATCCCTGTGATTTTCCCTGAGCTAGGTTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGTAGTCGGCCAGCGGCACCAGTAGCCAGGAAAGGAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTTTGATTTTCCAGGGAACACCGGCAAACATGGCTG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGGCGGCGCATTAACTCAGGTGGCGAACAAATTTAT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CATACGTGGCCAGGCAGCAATGCCGACAGCTTATTT
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTTGGTTAAAGAAGGCGTTTTAGTTTTGATACCTTA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGGAGAGCTTTCTTGCCGGTGAAGCCCATTGCCAG
GTTTCAATCCCTTATAGGTAAGCTACAAAC	TGAGATGGGGCATCAACGCTTTTGAATCTCCATTATC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	CTGCTTTTTTAATCGGCTTGCGTGCTACGGAGAGCCC
GTTTCAATCCCTTATAGGTAAGCTACAAAC	ATTTACGCCTCCGGTCGCTCACAACACGCAGTCAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC	GTTTTTTGGCCGATCTAAAAGAGTATGTGAAAATAA
GTTTCAATCCCTTATAGGTAAGCTACAAAC

Protein	Signature genes	Signature genes Name	Protein_function
AP018449.1\|BBB93550.1\|4780166_4781051_-\|TIR-domain-protein	unknown	unknown	gnl\|CDD\|379328
AP018449.1\|BBB93537.1\|4765190_4765925_-\|CRISPR-associated-protein-Cas6	cas6	COG1583_cas6_CAS-I:CAS-III:CAS-IV	gnl\|CDD\|224499
AP018449.1\|BBB93546.1\|4774362_4774833_-\|hypothetical-protein	csm2gr11	pfam03750_csm2gr11_CAS-III-A	gnl\|CDD\|367635
AP018449.1\|BBB93543.1\|4771292_4772417_-\|RAMP-superfamily-protein	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl\|CDD\|187793
AP018449.1\|BBB93547.1\|4774897_4777087_-\|hypothetical-protein	cas10	cd09680_cas10_CAS-III	gnl\|CDD\|187811
AP018449.1\|BBB93536.1\|4763650_4765177_-\|CRISPR-associated-protein	cas8b1	cd09730_cas8b1_CAS-I-B	gnl\|CDD\|378190
AP018449.1\|BBB93542.1\|4768746_4769154_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|214599
AP018449.1\|BBB93534.1\|4762294_4763203_-\|hypothetical-protein	cas7	cd09690_cas7_CAS-I-B	gnl\|CDD\|274217
AP018449.1\|BBB93541.1\|4767506_4767785_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93544.1\|4772418_4773459_-\|hypothetical-protein	csm4gr5	cd09663_csm4gr5_CAS-III-A	gnl\|CDD\|187794
AP018449.1\|BBB93545.1\|4773495_4774350_-\|RAMP-superfamily-protein	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl\|CDD\|187815
AP018449.1\|BBB93549.1\|4778346_4779891_-\|NB-ARC-domain-protein	unknown	unknown	unknown
AP018449.1\|BBB93535.1\|4763237_4763654_-\|hypothetical-protein	cas8b1	mkCas0119_cas8b1_CAS-I-B	gnl\|CDD\|378190
AP018449.1\|BBB93548.1\|4777144_4777918_-\|CRISPR-associated-protein-Cas6	cas6	mkCas0062_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
AP018449.1\|BBB93533.1\|4761572_4762289_-\|CRISPR-associated-protein	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
AP018449.1\|BBB93538.1\|4766160_4766508_-\|mRNA-interferase-EndoA	unknown	unknown	gnl\|CDD\|367091
AP018449.1\|BBB93540.1\|4767255_4767447_-\|hypothetical-protein	unknown	unknown	unknown
AP018449.1\|BBB93539.1\|4766501_4766756_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|223932

Protein	Function_ID	Function_description	E-value
AP018449.1\|BBB93537.1\|4765190_4765925_-\|CRISPR-associated-protein-Cas6	gnl\|CDD\|224499	COG1583, COG1583, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	4.36071e-38
AP018449.1\|BBB93546.1\|4774362_4774833_-\|hypothetical-protein	gnl\|CDD\|367635	pfam03750, Csm2_III-A, Csm2 Type III-A. Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2.	2.38504e-30
AP018449.1\|BBB93543.1\|4771292_4772417_-\|RAMP-superfamily-protein	gnl\|CDD\|187793	cd09662, Csm5_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	5.67866e-17
AP018449.1\|BBB93547.1\|4774897_4777087_-\|hypothetical-protein	gnl\|CDD\|187811	cd09680, Cas10_III, CRISPR/Cas system-associated protein Cas10. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Multidomain protein with permuted HD nuclease domain, palm domain and Zn-ribbon; signature gene for type III; also known as Csm1 family.	3.11168e-95
AP018449.1\|BBB93536.1\|4763650_4765177_-\|CRISPR-associated-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	6.0826e-23
AP018449.1\|BBB93542.1\|4768746_4769154_+\|hypothetical-protein	gnl\|CDD\|214599	smart00283, MA, Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.	0.00179989
AP018449.1\|BBB93534.1\|4762294_4763203_-\|hypothetical-protein	gnl\|CDD\|274217	TIGR02590, hypothetical_protein_MM_0563, CRISPR-associated protein Cas7/Csh2, subtype I-B/HMARI. This model represents one of two closely related CRISPR-associated proteins that belong to the larger family of TIGR01595. Members are the Csh2 protein of the Hmari subtype of CRISPR/cas system. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. The related model is TIGR02589, the Csd3 protein of the Dvulg CRISPR subtype.	1.40396e-76
AP018449.1\|BBB93550.1\|4780166_4781051_-\|TIR-domain-protein	gnl\|CDD\|379328	pfam13676, TIR_2, TIR domain. This is a family of bacterial Toll-like receptors.	2.85676e-14
AP018449.1\|BBB93544.1\|4772418_4773459_-\|hypothetical-protein	gnl\|CDD\|187794	cd09663, Csm4_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	8.44202e-42
AP018449.1\|BBB93545.1\|4773495_4774350_-\|RAMP-superfamily-protein	gnl\|CDD\|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	8.24336e-85
AP018449.1\|BBB93535.1\|4763237_4763654_-\|hypothetical-protein	gnl\|CDD\|378190	pfam09484, Cas_TM1802, CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	1.83152e-08
AP018449.1\|BBB93548.1\|4777144_4777918_-\|CRISPR-associated-protein-Cas6	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	2.23833e-18
AP018449.1\|BBB93533.1\|4761572_4762289_-\|CRISPR-associated-protein	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	1.63382e-31
AP018449.1\|BBB93538.1\|4766160_4766508_-\|mRNA-interferase-EndoA	gnl\|CDD\|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	1.71313e-26
AP018449.1\|BBB93539.1\|4766501_4766756_-\|hypothetical-protein	gnl\|CDD\|223932	COG0864, NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription].	0.000357602

>AP018449.1|BBB93542.1|4768746_4769154_+|hypothetical-protein
MFQQANFQQTNPFLQHVVNHGHSLITEVNKASSLCQEIVLNCDNIVAAINSGNPQNAVNLVQNIRNKASQVSQSTQFFNQAINERLDMSAYVLNTIQHKLNEISGAIQSLRGTTANYQMWQYGMQPSPWPSMPQQ
>AP018449.1|BBB93541.1|4767506_4767785_-|hypothetical-protein
MNVFAMISKEIFDEITEKADLSTNNPAYAESSEKLSQLYQKLQETLLEEFRKDQVELDSRYGARQAASGRGYFGLGFAAGIRFIIQCLQGRM
>AP018449.1|BBB93540.1|4767255_4767447_-|hypothetical-protein
MTPIWYVCDGEVETYSGQEADWKCSAVVIAPSPEEALIKVMQYHQQIINHVEVFHNGKTVVAI
>AP018449.1|BBB93539.1|4766501_4766756_-|hypothetical-protein
MNKNVTFSLPAELMDNIRKLVEEGYKTSINNLVREALEMYLKEVQQVQIREAMLRAAKDPLFQADVGECEFDFRHVDKECSIEW
>AP018449.1|BBB93538.1|4766160_4766508_-|mRNA-interferase-EndoA
MVIKKWTIYWVNLDPVVGSEQGGTRPVLLVSDDAVNVLNQVSILPITSLKDPNREIYPNEAFLPKAVSGLDKDSIVLAHQIRTLDKQRLQSVAGPIQEAETKAAIEAAMRVQLGL
>AP018449.1|BBB93537.1|4765190_4765925_-|CRISPR-associated-protein-Cas6
MQIVLRLNAANGLTLPIDYNHIVQSAIYHSIAPALATFLHEQGFTANGRVFRLFCFSRLLGPFTMDRNSGKITFGNDVRLVISSPVVDFVQSLANGLLQQGGWRLGSTFADITEIGAEQPVVESENINIRTLSPVTAYSTMSRPDGRKYTVYFQPGDPDYNALITANLQKKYQAFFREEPPEGEVKVKAAGQIKMNLLQYKGTVIKGYSGPLQLTGPQELLQMAVDCGLGSKNSQGFGCLALSN
>AP018449.1|BBB93536.1|4763650_4765177_-|CRISPR-associated-protein
MGFLQAVHALGVMAQKRSQGSVLADIMSFLQLPHPLGEAEAKRARVIRVWLKVANADSEILDVLSVDQIEPPAEYPAFSDEDKIKEMYLYRKPVGAAAQWSFSPLYKLGKGETEGKQALLGNNWQTDKDSRYYKIKRTVLNDFEVAGCFSAGGVERIMQGLVERADELAAFWTDRKRSYLLLFGVENNGVFLHPGQVPAFINYFRHKLTAPKEEQVKNSASSREKILRQCACCGSSAADVETLDKVFKFATFDKDSFLPGAKDGAGIKEKVFPVCPDCYALLSAGKTEMESRFVNTRIIPGINLYVLPEVCVGDMGATEIAAAETRDFFENGIAKESRVFRNLARKGTGLVYHFLFTELNNAQVKVHCLIEDVPPTRLNHLQSLWGETCTAFPMKNPAVDQDDDDGRINLDRAFRQIVSVMLSLAGKREQDKTVMREKALAMIGALLNNEVVELTGIKELMVSRFAGLFTDPDWLRPKGGEELSGLAKVRGMAEVVDFLIRVNGRREV
>AP018449.1|BBB93535.1|4763237_4763654_-|hypothetical-protein
MNLDWLGDFSDPYLRTPLGQGVFLSGIILGVVAKGQVGNSGDIDSAPMFKQIMFGKMQRRDLLRHLARVPELLGAYDGLKKSAPYIRQLSGKTGELLLKGGGELGVEGNFAFSVAFLNARDYYWKIFGKSNDSEAAEE
>AP018449.1|BBB93534.1|4762294_4763203_-|hypothetical-protein
MVIEKRREILFVYSVRDANPNGDPLNANHPRYDAESGQILVSDVRIKRTLRDQWLREGLPVFIDGEAKTLKSRIEELKKEFGVETGKDALKRCLDARVFGVTYALDKESFSWIGPVQFKWGRSLHQAKAELVQGTAAFASKDNSEQRSFRNEYIVPFVLIGAYGIVNQFAAKETGATEDDANKISEGLWQGTVNLITRSKVGHVPRMLLEVTYKPDFTGAAGALDEKLRLVSLDGNELTTEEQLTIRKPQDCLLDANKIGARLTQLRENIATIKIWLDGELSVKGLDELQKTLGEKLSLQTR
>AP018449.1|BBB93533.1|4761572_4762289_-|CRISPR-associated-protein
MAIAFEVSGPVAMFRRPYTTTSSVSFPFPPPTAIAGVLTAVCGHSNGSGEEASAAKYWQYLRGTRVAISLLNPIAWYSATLNFWNVKNPQQSPHIQVKHQFVKNPRYRIYVEGGLETELQGYLEQEAFVYTPYLGVAYAISDIYYCGVFAWEPVTNDNIAIHSILPQPAEQSFKVDIVATGGLFKERVPFQMTADRALAKSMTVLYPTSPQRGIHLTAWEGLDVTRYGDSCIAWFPAW
>AP018449.1|BBB93543.1|4771292_4772417_-|RAMP-superfamily-protein
MFATYEMEILTPVHIGSGCRILPLEYVLDRAQGKFVRVNMEALFRDRNFDSVLPRYINEVGTPGFRLYQFYPQACKFSCYELVTDQVGLAELESLSEGHVQAGIRDSCGWYVPGSSLKGALRTLVYKANMDGALAQTLSNKIAEKLADHKTKKEWATSAAEQALTGNPHFSLFRVVKIGDSSVVDSADVGLFVAKVLSMKKGTGHSWKGFSKGNVYNPSAATPLFFEALQPKVKLSGKFSIDSKLLNNVHVRLPNKQYLDNIWAKIREYQARYLHEEKEFFAGVGLNELVNAYDKLTAKNDKLEENEIIVQLGWGTGYKVKTLKEGVPEELFTRIVRRFNMTRREDFPYPKTRKVIFRDGRPETVPGFIKLKFL
>AP018449.1|BBB93544.1|4772418_4773459_-|hypothetical-protein
MQQRTPIYEDREKYIVGLKFKSPVHFGRYKDEDLARSGFWCGSDQLFSAMANAFNLFYGKTETEAFLAEFRTGAPPVILSSTFLMLEQTDTGAEPVYFLPKPCGLDLSAYFTDQKKAGKIAYLPHTVLELLANSKFDGSISEKYKPQGLFLVPKTCSEDLFVETECARVALDSMTAASMIYYITTVTYVESVGLYFMMDCRREWLAKIQTALRVLGDEGLGGERSYGMGSFTIANFRPSPSWSVDGDEALLLSAYYPSTQELRVMRTVAWEGRYRLREAGGYIYSGGDQGLRKKYLRVFAEGSVFGYKPVGQLLNVTPKGYNAHRVYRNCLAYTLPWNTAAQKGTG
>AP018449.1|BBB93545.1|4773495_4774350_-|RAMP-superfamily-protein
MAELKLLGKIIIKGRIETKTGLHIGGAQGNLEIGGLDNAVIKDAVGKPYIPGSSLKGKMRSLLERYEGYLQPDKLVYQKKGNEPIRIHMCDEPECPVCLIFGRNHGKQLQATTPEGREFRVTNVTPTRLQVRDAFLDELSLEGIKENLDLEYTEVKFENSLDRITSAANPRQQERVPRGAQFQFEMVYDVLCEDDMQRFAKVLTAMILLEDDYLGGAGSRGSGQVKFKAVEIIWKSREVYESGGQPEKTLVESTLDDIIRRGVKGLFTGIDAGETGSNRSNAAL
>AP018449.1|BBB93546.1|4774362_4774833_-|hypothetical-protein
MPNEQMRQDGRQNRGYPHGNQRNTGIVSIADEVSAKAEIIIDPAKDAKGNELISCAQKLGQYLAVNVRMTTSQIRNLFAEAVRIKKIYGNDNKGPYEVNLLRAKFAYNAGRFREVKDFQKIADRMLLHIDSKEKFTRFFDFFEAVVAYHKQYGGKE
>AP018449.1|BBB93547.1|4774897_4777087_-|hypothetical-protein
MDNLYLAALLHRIGNLLVEPVEAFLPDTGDWQTVRRLIRGINNPDAEDELLLAAAGRIVGYRQDDAGVDGNFANPLLSVLASINIDKGVPPGGYHALDETAEEFSRLQRDFKAELVELLASSSDKVDWQDTLLYLFEKYLTVVPCSRGISATAVSMYEFLKIVAAVAVSLAAGSPGQEELRELIAVVDAGNLAVSDVGNKHRFMLLVGDITGIQEFLYDVPMKYAAKNLRGRSFFVSYFAKMTADYILSRENMPRANAVMAGGGKFALLLPIAASSNVATYREYIEQGIFAAFQGKLAVFFADIPLSAADLLPGRFSRVWSEAGKLLNAAKNHRWASILHKKPLAVLGPFKSADHPCGICRRPVAASEDNKLCDFCQSFVKFSESLAKGGFLSEVKIEPASGEIRTLDDLFTRFGKQVRCCDKPDKTGFNYLLNSKAFLEVAADGFYSAPQLITDRTFADLAETAEGEKTWGVLRGDVDDLSKIFHQGLGDNGDLAHFVILSRRIAEFFSVALNDLLRQYRAKIYIVYAGGDDFFIVGAWSALPEVARVIRRKFKEYCSGNPNLTLSMAIKLANNTKYPLYRVAEEAGEMLDDKAKSDGKDKIAFLTTVFTWNEFDRAIDVKNKIKAIIGAGEANALLNCLYNARKLADEAKTTGDIFRVWQVVYSLSRYRSMVREEAKGLVSELIDTVLEKNNRLYIHTWEVARWAELELRKMELQDRLAKAEQEVYI
>AP018449.1|BBB93548.1|4777144_4777918_-|CRISPR-associated-protein-Cas6
MLVNLRLISEGKAVFFFDTIYDELARLIGSIVDRQPERYSPVQHLGLQRQSSGCLAPFTFSEITAPKIKHTQNGFWVIGGAGIHIASPSTEFGLNLLCGLAKVKTLTIGEVKLGLKGSFVPHGNIQPGYEMVCLSPVIVAADDGQNDFLRYEDNPVRYSERLRQGLMKKYRDYYGYDPLDDRFLFFYDEEYLKNGLSACVVKRFGREFFGQSAPFTVAGSLELTGLAVQAGLGEKTEMGFGMIADRKLPKRASDGWR
>AP018449.1|BBB93549.1|4778346_4779891_-|NB-ARC-domain-protein
MDNVIEDYAALAKALKLTNDNVCRAELVNLVLDNLCQKTSWLLIFDNVKGTNDVDSIYKYIPSSESGHVLITSRDSRDWDRIAKPLPIGVMKKTDAQKFLKKRTGESDAEAIATLADEMEYLPLALEQAGKYIRDTGCGVRGYLNLFRKEKTKLLRDDEVVRADKCLLNVFATSQISYQELKTNSDAIALLRLFAFLASDNISVKDLLRIGSESLPDDMPVLTDMAVFNEAIKALNAYSFVRNNHGIIKVHRLVQTAVQCWMTEVERKRMLGTALKVVTKAYDFGKTQCVKSLTPHISMVIEHAENCAIYLDEAENLAYKLGEWYFHKEEFRIARNTIERVLIINEGHYGINNSKAADIINMLGCILKKEGYLENADACDIWESEIRQNTPLTAHSYIIICKALGNDDNVRNHYTKVIAITQKTSKGNEYNYLMNKRNCGDAWYLMREYMKALQQYRDALKINFKKTRKKIIFGREIFRRISVILPRHIPEWEMEFGLVIVINGHLKALNADMD
>AP018449.1|BBB93550.1|4780166_4781051_-|TIR-domain-protein
MISVTHDISGPVERYLQANPHIRFRKRVNILPENGPGGDSIKFAAEAVSYANAVKDIADNLRYGDNIKNFHLFFDCPLSLAIFIGHRLTACNRIQTYEFLDAEHDKDLYGLSWGSIGKTDTQETVPSNAGITSVINEIVDLQQSGKDKVEIFISYSHVDDKFRQELVKHLKSRERKGLILCWYDRMIEAEWEPEIKRHLESSKIILLLVSVDFINSDYCWDVEMKRAMERHDNGEAIVIPVILRDCDWKDAPFAKLLAIPTDGKPINKWDDRDSAFLDVAMYIRRKIEKMVNPS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
AP018449_10	10.11\|4758272\|36\|AP018449\|CRISPRCasFinder,CRT,PILER-CR	4758272-4758307	36	NZ_CP016619	Microvirga ossetica strain V5/3m plasmid unnamed2, complete sequence	514601-514636	6	0.833
AP018449_11	11.20\|4770687\|35\|AP018449\|CRISPRCasFinder,CRT,PILER-CR	4770687-4770721	35	MG765274	Lactobacillus phage Maenad, complete genome	77651-77685	6	0.829
AP018449_6	6.1\|4694535\|38\|AP018449\|CRT	4694535-4694572	38	MF979559	Ralstonia phage DU_RP_I, complete genome	5454-5491	7	0.816
AP018449_9	9.27\|4753496\|35\|AP018449\|CRT,PILER-CR,CRISPRCasFinder	4753496-4753530	35	NZ_CP021811	Sinorhizobium meliloti strain Rm41 plasmid accessoryA, complete sequence	5536-5570	9	0.743
AP018449_9	9.27\|4753496\|35\|AP018449\|CRT,PILER-CR,CRISPRCasFinder	4753496-4753530	35	NC_018682	Sinorhizobium meliloti Rm41 plasmid pRM41A, complete sequence	163610-163644	9	0.743

1. spacer 10.11|4758272|36|AP018449|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP016619 (Microvirga ossetica strain V5/3m plasmid unnamed2, complete sequence) position: , mismatch: 6, identity: 0.833

-tccaccgctatctggagtttcgtgaccgcctgcagg	CRISPR spacer
atgtcccgc-atcaggattttcgtgaccgcctgcagg	Protospacer
 * . **** *** *** *******************

2. spacer 11.20|4770687|35|AP018449|CRISPRCasFinder,CRT,PILER-CR matches to MG765274 (Lactobacillus phage Maenad, complete genome) position: , mismatch: 6, identity: 0.829

tggagagctttcttgccggtgaagcccattgccag	CRISPR spacer
tgcattgctttcttgccagtgaagcccatagccaa	Protospacer
** *  ***********.*********** ****.

3. spacer 6.1|4694535|38|AP018449|CRT matches to MF979559 (Ralstonia phage DU_RP_I, complete genome) position: , mismatch: 7, identity: 0.816

taagaatttgctccttgaatccatactctttggatccg	CRISPR spacer
ccatgagttgctccttgaatccgtactccttggatccg	Protospacer
. * .* ***************.*****.*********

4. spacer 9.27|4753496|35|AP018449|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP021811 (Sinorhizobium meliloti strain Rm41 plasmid accessoryA, complete sequence) position: , mismatch: 9, identity: 0.743

tgattgcggtacacctgaccggtccgcc----ataccat	CRISPR spacer
tgcttgcggtaaacctgaccggtccgttcctgatg----	Protospacer
** ******** **************..    **.

5. spacer 9.27|4753496|35|AP018449|CRT,PILER-CR,CRISPRCasFinder matches to NC_018682 (Sinorhizobium meliloti Rm41 plasmid pRM41A, complete sequence) position: , mismatch: 9, identity: 0.743

tgattgcggtacacctgaccggtccgcc----ataccat	CRISPR spacer
tgcttgcggtaaacctgaccggtccgttcctgatg----	Protospacer
** ******** **************..    **.

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

558097 : 586771

Moraxella_phage(12.5%)

bacteriocin,protease

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBB89860.1\|558097_560410_-\|protease	Lon protease 1	A0A0R6PGP8	Moraxella_phage	8.2e-181	45.2
BBB89861.1\|560578_562288_-\|protease	Lon protease 2	NA	NA	NA	NA
BBB89862.1\|562431_563694_-\|protease	ATP-dependent Clp protease ATP-binding subunit ClpX	G3M9Z9	Bacillus_virus	2.3e-145	64.0
BBB89863.1\|563706_564312_-\|protease	ATP-dependent Clp protease proteolytic subunit	A0A223W000	Agrobacterium_phage	3.8e-53	55.6
BBB89864.1\|564343_565627_-	trigger factor	NA	NA	NA	NA
BBB89865.1\|566240_567482_+\|bacteriocin	antilisterial bacteriocin subtilosin biosynthesis protein AlbA	NA	NA	NA	NA
BBB89866.1\|568546_569020_-	haloacid dehalogenase-like hydrolase	NA	NA	NA	NA
BBB89867.1\|569049_570330_-	enolase	W6LP63	Streptococcus_phage	5.5e-126	55.8
BBB89868.1\|570937_572233_-	hexokinase	NA	NA	NA	NA
BBB89869.1\|572363_572660_+	hypothetical protein	NA	NA	NA	NA
BBB89870.1\|572801_574046_-	diaminopimelate decarboxylase	NA	NA	NA	NA
BBB89871.1\|574571_574814_+	hypothetical protein	NA	NA	NA	NA
BBB89872.1\|574831_576979_-	modification methylase PaeR7I	Q8V6N5	Halorubrum_phage	3.3e-06	33.1
BBB89873.1\|577078_578230_+	DNA polymerase IV	A0A1W6JNT0	Morganella_phage	3.2e-24	28.8
BBB89874.1\|578210_579071_-	hypothetical protein	NA	NA	NA	NA
BBB89875.1\|579111_579756_-	integral membrane protein TerC family protein	A0A0S4KZH7	Pseudomonas_phage	1.0e-27	39.8
BBB89876.1\|580223_580475_+	hypothetical protein	NA	NA	NA	NA
BBB89877.1\|580500_580746_+	hypothetical protein	NA	NA	NA	NA
BBB89878.1\|580750_582691_-	methyl-accepting chemotaxis protein McpB	A0A2H4J162	uncultured_Caudovirales_phage	2.2e-17	50.0
BBB89879.1\|582727_583186_-	hypothetical protein	NA	NA	NA	NA
BBB89880.1\|583226_583883_-	4-hydroxy-4-methyl-2-oxoglutarate aldolase	NA	NA	NA	NA
BBB89881.1\|583913_584087_-	hypothetical protein	NA	NA	NA	NA
BBB89882.1\|584321_585308_-	4-hydroxy-4-methyl-2-oxoglutarate aldolase	NA	NA	NA	NA
BBB89883.1\|585335_585470_-	hypothetical protein	NA	NA	NA	NA
BBB89884.1\|585694_586771_-\|protease	metalloprotease LoiP precursor	NA	NA	NA	NA

DBSCAN-SWA_2

949851 : 983626

Streptococcus_phage(25.0%)

transposase,protease,coat,integrase

attL 956182:956197|attR 977116:977131

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBB90210.1\|949851_950715_-\|transposase	PD-(D/E)XK nuclease family transposase	NA	NA	NA	NA
BBB90211.1\|951165_951927_-	putative oxidoreductase	NA	NA	NA	NA
BBB90212.1\|952089_953310_-	inner membrane transport protein YnfM	NA	NA	NA	NA
BBB90213.1\|953539_954409_-	methionine aminopeptidase	NA	NA	NA	NA
BBB90214.1\|954451_954796_-	multiple antibiotic resistance protein MarA	NA	NA	NA	NA
BBB90215.1\|954980_955427_-	HTH-type transcriptional regulator MhqR	NA	NA	NA	NA
BBB90216.1\|955595_955970_-	HTH-type transcriptional regulator AdhR	NA	NA	NA	NA
956182:956197	attL	NA	NA	NA	NA
BBB90217.1\|956377_957544_+	alcohol dehydrogenase YqhD	NA	NA	NA	NA
BBB90218.1\|957836_958346_-	SnoaL-like polyketide cyclase	NA	NA	NA	NA
BBB90219.1\|958721_960002_+\|transposase	transposase IS116/IS110/IS902 family protein	M1NSC9	Streptococcus_phage	1.7e-63	42.9
BBB90220.1\|960215_960620_+	nitrite and sulphite reductase 4Fe-4S domain protein	NA	NA	NA	NA
BBB90221.1\|961072_961699_+	transcriptional regulator AcuR	NA	NA	NA	NA
BBB90222.1\|961901_963839_+	NADH oxidase	NA	NA	NA	NA
BBB90223.1\|964632_965568_+\|integrase	integrase core domain protein	NA	NA	NA	NA
BBB90224.1\|965824_966259_-	acetyltransferase YpeA	NA	NA	NA	NA
BBB90225.1\|966289_966490_-	rRNA large subunit methyltransferase	NA	NA	NA	NA
BBB90226.1\|966817_967138_-	nucleotidyltransferase domain protein	NA	NA	NA	NA
BBB90227.1\|967571_968423_-\|transposase	PD-(D/E)XK nuclease family transposase	NA	NA	NA	NA
BBB90228.1\|968737_970183_-	multidrug resistance protein stp	NA	NA	NA	NA
BBB90229.1\|970304_970784_-	ribosomal RNA large subunit methyltransferase H	NA	NA	NA	NA
BBB90230.1\|970801_971914_-\|protease	putative serine protease HtrA	W5SAB9	Pithovirus	1.5e-10	32.5
BBB90231.1\|971948_972722_-	putative metallo-hydrolase YycJ	A0A0C5AFC1	Paenibacillus_phage	5.8e-38	35.6
BBB90232.1\|972927_975639_+	sporulation kinase E	NA	NA	NA	NA
BBB90233.1\|975635_977009_-	phosphomannomutase/phosphoglucomutase	A0A127AWJ1	Bacillus_phage	1.8e-42	28.3
BBB90234.1\|977445_978825_-	periplasmic [NiFeSe] hydrogenase large subunit	NA	NA	NA	NA
977116:977131	attR	NA	NA	NA	NA
BBB90235.1\|978833_980075_-	periplasmic [NiFeSe] hydrogenase small subunit precursor	NA	NA	NA	NA
BBB90236.1\|980288_981170_-	hypothetical protein	NA	NA	NA	NA
BBB90237.1\|981464_982106_-	deoxyribose-phosphate aldolase	NA	NA	NA	NA
BBB90238.1\|982201_982312_-	hypothetical protein	NA	NA	NA	NA
BBB90239.1\|982327_982762_-	transcriptional regulator PerR	NA	NA	NA	NA
BBB90240.1\|983302_983626_-\|coat	coat F domain protein	NA	NA	NA	NA

DBSCAN-SWA_3

1885961 : 1905321

Bacillus_phage(40.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBB91013.1\|1885961_1887389_-	ammonium transporter NrgA	H8ZJB2	Ostreococcus_tauri_virus	5.5e-42	33.0
BBB91014.1\|1887963_1889190_-	tyrosine recombinase XerC	A0A0U3U8Y8	Bacillus_phage	7.5e-16	27.0
BBB91015.1\|1889238_1889655_-	metallopeptidase ImmA	D2XR38	Bacillus_phage	3.1e-30	50.0
BBB91016.1\|1889661_1890465_-	transcriptional repressor DicA	S6C481	Thermus_phage	1.0e-13	46.0
BBB91017.1\|1890640_1890904_+	hypothetical protein	A0A1P8BL13	Lactococcus_phage	2.9e-10	47.9
BBB91018.1\|1890896_1891751_+	ORF6N domain protein	A0A0S2MV65	Bacillus_phage	8.1e-25	49.2
BBB91019.1\|1891766_1892015_+	hypothetical protein	NA	NA	NA	NA
BBB91020.1\|1892064_1892694_+	hypothetical protein	A0A1W6JPC3	Staphylococcus_phage	4.7e-38	43.4
BBB91021.1\|1892798_1892969_+	hypothetical protein	NA	NA	NA	NA
BBB91022.1\|1892928_1893138_-	hypothetical protein	NA	NA	NA	NA
BBB91023.1\|1893232_1893457_+	hypothetical protein	NA	NA	NA	NA
BBB91024.1\|1893453_1893780_+	hypothetical protein	NA	NA	NA	NA
BBB91025.1\|1893943_1894429_+	hypothetical protein	NA	NA	NA	NA
BBB91026.1\|1894448_1894682_+	acyl carrier protein	NA	NA	NA	NA
BBB91027.1\|1894839_1895358_+	hypothetical protein	NA	NA	NA	NA
BBB91028.1\|1895382_1896678_+	chromosome segregation protein	A0A097BY67	Enterococcus_phage	4.7e-141	59.9
BBB91029.1\|1896677_1897808_+	hypothetical protein	Q5YA96	Bacillus_phage	3.1e-101	57.9
BBB91030.1\|1897837_1898317_+	hypothetical protein	A0A0K2CZ91	Paenibacillus_phage	3.0e-37	58.3
BBB91031.1\|1898318_1899914_+	UvrABC system protein B	A0A2I7SC38	Paenibacillus_phage	6.4e-233	76.2
BBB91032.1\|1899913_1902136_+	regulatory protein RepA	Q5YA88	Bacillus_phage	1.3e-295	64.7
BBB91033.1\|1902442_1902676_+	hypothetical protein	NA	NA	NA	NA
BBB91034.1\|1902681_1902948_+	hypothetical protein	NA	NA	NA	NA
BBB91035.1\|1902947_1903142_+	hypothetical protein	NA	NA	NA	NA
BBB91036.1\|1903147_1903537_+	endodeoxyribonuclease RusA	Q5YA86	Bacillus_phage	3.3e-42	61.8
BBB91037.1\|1903645_1904002_+	hypothetical protein	A0A2K9V403	Faecalibacterium_phage	2.6e-33	57.5
BBB91038.1\|1904015_1904276_+	hypothetical protein	NA	NA	NA	NA
BBB91039.1\|1904434_1904578_+	hypothetical protein	NA	NA	NA	NA
BBB91040.1\|1904766_1905321_+	hypothetical protein	R9U4A4	Rhizobium_phage	3.5e-29	49.3

DBSCAN-SWA_4

1909598 : 1928099

Vibrio_phage(43.75%)

plate,portal,terminase,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBB91045.1\|1909598_1911425_+\|terminase	Phage terminase large subunit	A0A2K9V301	Faecalibacterium_phage	6.6e-133	43.4
BBB91046.1\|1911433_1911640_+	hypothetical protein	NA	NA	NA	NA
BBB91047.1\|1911657_1913166_+\|portal	phage portal protein, lambda family	A0A2K9V303	Faecalibacterium_phage	4.1e-96	38.6
BBB91048.1\|1913110_1915153_+	hypothetical protein	A0A1W6JT88	Pseudomonas_phage	3.9e-65	45.9
BBB91049.1\|1915192_1915660_+	hypothetical protein	NA	NA	NA	NA
BBB91050.1\|1915683_1915989_+	hypothetical protein	A0A2K9V315	Faecalibacterium_phage	2.2e-09	35.3
BBB91051.1\|1915985_1916555_+\|tail	Prophage minor tail protein Z	NA	NA	NA	NA
BBB91052.1\|1916560_1917037_+	hypothetical protein	NA	NA	NA	NA
BBB91053.1\|1917008_1917278_+	hypothetical protein	NA	NA	NA	NA
BBB91054.1\|1917284_1918742_+\|tail	phage tail sheath protein	A0A059WKP9	Vibrio_phage	4.5e-169	58.4
BBB91055.1\|1918757_1919276_+\|tail	phage tail tube protein FII	A0A067ZJA9	Vibrio_phage	3.4e-50	55.0
BBB91056.1\|1919289_1919577_+	hypothetical protein	NA	NA	NA	NA
BBB91057.1\|1919754_1922136_+\|tail	phage-related minor tail protein	A0A1W6JT50	Escherichia_phage	1.1e-84	40.9
BBB91058.1\|1922128_1922332_+	phage Tail Protein X	A0A2K9V482	Faecalibacterium_phage	1.9e-12	50.7
BBB91059.1\|1922336_1923077_+	Phage late control gene D protein	A0A067ZG47	Vibrio_phage	7.2e-46	41.4
BBB91060.1\|1923085_1923388_+	Phage late control gene D protein	A0A0C5AJ59	Bacteriophage	9.5e-13	46.6
BBB91061.1\|1923387_1923861_+\|plate	phage-related baseplate assembly protein	A0A067ZIM2	Vibrio_phage	2.4e-18	41.8
BBB91062.1\|1923869_1924187_+	gene 25-like lysozyme	A0A067ZJ13	Vibrio_phage	2.4e-19	52.6
BBB91063.1\|1924192_1925047_+	phage P2 GpU	A0A067ZI88	Vibrio_phage	2.1e-20	38.9
BBB91064.1\|1925043_1926162_+\|plate	baseplate J-like protein	A0A059WFM2	Vibrio_phage	2.1e-97	50.5
BBB91065.1\|1926151_1926907_+\|tail	Phage tail protein	A0A0C5AJ63	Bacteriophage	8.2e-29	38.3
BBB91066.1\|1926893_1928099_+	hypothetical protein	A0A0C5AEQ0	Bacteriophage	2.7e-34	49.0

DBSCAN-SWA_5

3299208 : 3313559

Synechococcus_phage(20.0%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
BBB92328.1\|3299208_3299967_+	sensor protein KdpD	Q8QKV7	Ectocarpus_siliculosus_virus	1.0e-15	24.0
BBB92329.1\|3299963_3300653_+	KDP operon transcriptional regulatory protein KdpE	NA	NA	NA	NA
BBB92330.1\|3300700_3301039_+	nitrogen regulatory protein P-II	NA	NA	NA	NA
BBB92331.1\|3301252_3302566_+	ammonium transporter NrgA	H8ZJB2	Ostreococcus_tauri_virus	3.3e-78	42.1
BBB92332.1\|3302824_3303523_+	gamma-DL-glutamyl hydrolase precursor	A0A1V0DZX6	Clostridioides_phage	4.4e-21	44.6
BBB92333.1\|3303722_3304199_+	toxin-antitoxin biofilm protein TabA	NA	NA	NA	NA
BBB92334.1\|3304663_3305155_+	N5-carboxyaminoimidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.4e-21	44.6
BBB92335.1\|3305358_3306069_+	phosphoribosylaminoimidazole-succinocarboxamide synthase	G8EYA2	Synechococcus_phage	8.2e-39	38.4
BBB92336.1\|3306259_3307693_+	amidophosphoribosyltransferase precursor	A0A0M3SGR2	Mollivirus	7.4e-63	35.0
BBB92337.1\|3307734_3308805_+	phosphoribosylformylglycinamidine cyclo-ligase	Q58MH8	Prochlorococcus_phage	2.5e-68	43.5
BBB92338.1\|3308825_3309020_+	hypothetical protein	NA	NA	NA	NA
BBB92339.1\|3309050_3309665_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	2.9e-24	38.0
BBB92340.1\|3309693_3311238_+	bifunctional purine biosynthesis protein PurH	Q58MG4	Prochlorococcus_phage	4.1e-75	50.3
BBB92341.1\|3311789_3313559_+\|tRNA	glutamine--tRNA ligase	A0A222YZ70	Escherichia_phage	4.3e-190	59.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. AP018449

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection