CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP028419	Aeromonas hydrophila strain WCX23 plasmid pWCX23_1, complete sequence	0 crisprs	DEDDh	0	0	0	0
CP028418	Aeromonas hydrophila strain WCX23 chromosome, complete genome	8 crisprs	WYL,csa3,DEDDh,DinG,cas3	0	5	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP028418_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028418_1

102594-102701

Orphan

Consensus_repeat	Method
GAGCCCAAGGCTCCGTTTTCACTGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028418_1

>merge|CP028418|1|102594-102701|CRISPRCasFinder
GAGCCCAAGGCTCCGTTTTCACTGCGGTATCCATCCCGAACGCAGCACCGCCGCGCTCCGTCTACTGTGATGAATAAAAAACAGAGCCCAAGGCTCTGTTTTCACTGC

>CP028418|1|1|102594-102701|CRISPRCasFinder
GAGCCCAAGGCTCCGTTTTCACTGC	GGTATCCATCCCGAACGCAGCACCGCCGCGCTCCGTCTACTGTGATGAATAAAAAACA
GAGCCCAAGGCTCTGTTTTCACTGC

Protein	Signature genes	Signature genes Name	Protein_function
CP028418.1\|AZU45947.1\|97980_98421_+\|membrane-protein	unknown	unknown	gnl\|CDD\|378336
CP028418.1\|AZU45960.1\|110339_111458_-\|agmatine-deiminase	unknown	unknown	gnl\|CDD\|377332
CP028418.1\|AZU45946.1\|97274_97817_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|350341
CP028418.1\|AZU45951.1\|101058_102507_+\|catalase	unknown	unknown	gnl\|CDD\|163712
CP028418.1\|AZU45943.1\|95587_96247_+\|hydrolase	unknown	unknown	gnl\|CDD\|319796
CP028418.1\|AZU45955.1\|105570_105951_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU45956.1\|106148_107528_+\|phosphatidic-acid-phosphatase	unknown	unknown	gnl\|CDD\|239486
CP028418.1\|AZU45961.1\|111625_112519_+\|regulatory-protein-LysR	unknown	unknown	gnl\|CDD\|182990
CP028418.1\|AZU45952.1\|102898_103225_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|369340
CP028418.1\|AZU45958.1\|108614_108746_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU45948.1\|98569_99469_+\|membrane-protein	unknown	unknown	gnl\|CDD\|223769
CP028418.1\|AZU45944.1\|96262_96871_-\|diguanylate-cyclase	unknown	unknown	gnl\|CDD\|143635
CP028418.1\|AZU45949.1\|99555_100413_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
CP028418.1\|AZU45953.1\|103440_104604_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236766
CP028418.1\|AZU45942.1\|94540_95548_+\|spermidine/putrescine-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|226361
CP028418.1\|AZU45954.1\|104742_105516_+\|amino-acid-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270422
CP028418.1\|AZU45957.1\|107524_108610_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182881
CP028418.1\|AZU45945.1\|96828_97248_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|350337
CP028418.1\|AZU45959.1\|108967_109909_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU45950.1\|100409_100895_-\|acetyltransferase-GCN5	unknown	unknown	gnl\|CDD\|182263

Protein	Function_ID	Function_description	E-value
CP028418.1\|AZU45947.1\|97980_98421_+\|membrane-protein	gnl\|CDD\|378336	pfam09980, DUF2214, Predicted membrane protein (DUF2214). This domain, found in various hypothetical bacterial proteins, has no known function.	8.13143e-42
CP028418.1\|AZU45960.1\|110339_111458_-\|agmatine-deiminase	gnl\|CDD\|377332	pfam04371, PAD_porph, Porphyromonas-type peptidyl-arginine deiminase. Peptidyl-arginine deiminase (PAD) enzymes catalyze the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia. PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (pfam03068), which is a metalloenzyme. PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologs). The predicted catalytic residues in PPAD are Asp130, Asp187, His236, Asp238 and Cys351. These are absolutely conserved with the exception of Asp187 which is absent in two family members. PPAD is also able to catalyze the deimination of free L-arginine, but has primarily peptidyl-arginine specificity. It may have a FMN cofactor.	4.0405e-137
CP028418.1\|AZU45946.1\|97274_97817_-\|diguanylate-cyclase	gnl\|CDD\|350341	cd18773, PDC1_HK_sensor, first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains. Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.	2.38422e-13
CP028418.1\|AZU45951.1\|101058_102507_+\|catalase	gnl\|CDD\|163712	cd08156, catalase_clade_3, Clade 3 of the heme-binding enzyme catalase. Catalase is a ubiquitous enzyme found in both prokaryotes and eukaryotes, which is involved in the protection of cells from the toxic effects of peroxides. It catalyzes the conversion of hydrogen peroxide to water and molecular oxygen. Catalases also utilize hydrogen peroxide to oxidize various substrates such as alcohol or phenols. Clade 3 catalases are the most abundant subfamily and are found in all three kingdoms of life; they have a relatively small subunit size of 43 to 75 kDa, and bind a protoheme IX (heme b) group buried deep inside the structure. Clade 3 catalases also bind NADPH as a second redox-active cofactor. They form tetramers, and in eukaryotic cells, catalases are located in peroxisomes.	0
CP028418.1\|AZU45943.1\|95587_96247_+\|hydrolase	gnl\|CDD\|319796	cd02612, HAD_PGPPase, phosphatidylglycerol-phosphate phosphatase, similar to Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C. This family includes Escherichia coli K-12 phosphatidylglycerol-phosphate phosphatase C, PgpC (previously named yfhB) which catalyzes the dephosphorylation of phosphatidylglycerol-phosphate (PGP) to phosphatidylglycerol (PG). This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	2.41201e-63
CP028418.1\|AZU45956.1\|106148_107528_+\|phosphatidic-acid-phosphatase	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	1.74263e-17
CP028418.1\|AZU45961.1\|111625_112519_+\|regulatory-protein-LysR	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	4.92644e-63
CP028418.1\|AZU45952.1\|102898_103225_-\|hypothetical-protein	gnl\|CDD\|369340	pfam07383, DUF1496, Protein of unknown function (DUF1496). This family consists of several bacterial proteins of around 90 residues in length. Members of this family seem to be found exclusively in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.	2.35978e-21
CP028418.1\|AZU45948.1\|98569_99469_+\|membrane-protein	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.14029e-15
CP028418.1\|AZU45944.1\|96262_96871_-\|diguanylate-cyclase	gnl\|CDD\|143635	cd01949, GGDEF, Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.	5.34723e-48
CP028418.1\|AZU45949.1\|99555_100413_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	4.90274e-26
CP028418.1\|AZU45953.1\|103440_104604_+\|hypothetical-protein	gnl\|CDD\|236766	PRK10811, rne, ribonuclease E; Reviewed.	1.2829e-10
CP028418.1\|AZU45942.1\|94540_95548_+\|spermidine/putrescine-ABC-transporter-ATP-binding-protein	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	1.23143e-140
CP028418.1\|AZU45954.1\|104742_105516_+\|amino-acid-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270422	cd13704, PBP2_HisK, The periplasmic sensor domain of histidine kinase receptors; the type 2 periplasmic binding fold protein. This subfamily includes the periplasmic sensor domain of the histidine kinase receptors (HisK) which are elements of the two-component signal transduction systems commonly found in bacteria and lower eukaryotes. Typically, the two-component system consists of a membrane-spanning histidine kinase sensor and a cytoplasmic response regulator. The two-component systems serve as a stimulus-response coupling mechanism to enable microorganisms to sense and respond to changes in environmental conditions. Extracellular stimuli such as small molecule ligands and ions are detected by the N-terminal periplasmic sensing domain of the sensor kinase receptor, which regulate the catalytic activity of the cytoplasmic kinase domain and promote ATP-dependent autophosphorylation of a conserved histidine residue. The phosphate is then transferred to a conserved aspartate in the response regulator through a phospho-transfer mechanism, and the activity of the response regulator is in turn regulated. The sensor domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space through their function as an initial high-affinity binding component. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.97903e-20
CP028418.1\|AZU45957.1\|107524_108610_+\|hypothetical-protein	gnl\|CDD\|182881	PRK10983, PRK10983, AI-2E family transporter YdiK.	2.61013e-141
CP028418.1\|AZU45945.1\|96828_97248_-\|hypothetical-protein	gnl\|CDD\|350337	cd12912, PDC2_MCP_like, second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains. Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the second PDC domain of Methyl-accepting chemotaxis proteins (MCPs), Histidine kinases (HKs), and other similar domains. Many members contain both HAMP (HK, Adenylyl cyclase, MCP, and Phosphatase) and MCP domains, which are signalling domains that interact with protein partners to relay a signal. MCPs are part of a transmembrane protein complex that controls bacterial chemotaxis. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.	5.04541e-08
CP028418.1\|AZU45950.1\|100409_100895_-\|acetyltransferase-GCN5	gnl\|CDD\|182263	PRK10140, PRK10140, N-acetyltransferase.	2.23474e-54

>CP028418.1|AZU45951.1|101058_102507_+|catalase
MNDKTLHSANGAPVVDNNNSLTAGPRGPVLMQDIWLMEKLAHFDRERIPERVVHAKGSGAYGTFTVTHDISAFSKADLFNAVGKQTPVFLRFSTVAGEKGAADAERDVRGFALKFYTEQGNWDLVGNNTPVFFIRDPLKFPDFIHTQKRDPRTNLRSATAAWDFWSRHPESLHQVTILFSDRGIPKSLREMNGYGSHTFSFINDANERFWVKFHFKTEQGHSFYTDEEAATAVGQDRETSQADLFNAIERGDFPRWKVYVQVMPEAEAQTYQIHPFDLTKVWPHSDYPLIPVGVLELNQNPDNYFAHVEQAAFTPANVVPGIGFSPDRMLQGRLFSYGDTQRYRLGVNHGLLPVNAPRCPFHHGAHRDGAMRADSNGGASPNYQPNRFGTQQPSEQHEPALSLEGAALHYDFRDYDSDYYSQPGNLFRIMDEGQRSRLAANLARSLVNVEDDAIVAAQLKHFEQADPEYAKRVELALAALQR
>CP028418.1|AZU45950.1|100409_100895_-|acetyltransferase-GCN5
MQITIRHAEPADAPALRDLYAMPNAQAGTLQLPYPTLGVWQKRLESGSVVALVAEVDGLLVGQLSLHMDPNPRRKHVACIGMGVRDDWAGKGVGSALLGAVLEMADNWLNLQRVELTVYTDNQGALALYRKFGFVEEGLARGYAFRQGEYVDALYMARIRP
>CP028418.1|AZU45949.1|99555_100413_-|AraC-family-transcriptional-regulator
MIDYRRRLIPVLRALEQDPDLSIEALAERACLSLYHFHRVFTAVAGEAPGEMCRRLRMQRAAWQLRYTDASITAIALGAGLGSSQAFAKAFRRYYGCTPGAFRSDKSKNGHLESKDGHAWDGPSPYAEGHSSARSNTMKTVEMDARTLAYIRVTGPYGEGYDAVCGRLHQWAAVRGLEGGEWIFIYHDNPEVTPPAQCRTDIGITVPPQTRGEGEVETQLIPAGRYAQSRYLITDRNQYGPRWQEHVGDIVAAGLEFGSGPCFELYHSVSNDPLRDDVSFCSSVR
>CP028418.1|AZU45948.1|98569_99469_+|membrane-protein
MRSNMMLLMAAAIWGLGFVAQRLGMDHMGPYTFNGLRFLLGAASLLPLLWWLKSRQPRAQPGDRRLLLTGGLIAGTVLFSAASLQQVGLLYTTAAKAGFITGLYIILVPVIGLALRHKTGANTWVGALIAMAGLYYLSVTEDFTIGYGDLLQVVGALFWAVHLLVLDHYSSRVVPILLAGVQFVVCGLLSLGTALVIETPSLSGAVAGWQALLYAGLVSVGVGYTLQVVGQRGAHPAHAAIILSLETVFAAIGGVLLLGETLDERAMVGCALMLAGMLISQIRLRWWWKSRRDKVPSQP
>CP028418.1|AZU45947.1|97980_98421_+|membrane-protein
MLNPDLLMALHYCAVITLTGAITSEYFLFRRGMSIEQVRKLLLADGLAALALLLIFITGVLQVLAHPDEPSVLLANPGYRTKLLLFCVMAISFGYPSRLFYRWRRSLRQGRAPMVSIQQQFWVIWILRGNLLLLALIPLLAGIANG
>CP028418.1|AZU45946.1|97274_97817_-|diguanylate-cyclase
MGLLLLFIPVLMLGGIYYLHMERSLQNELQQRLLATNHQLRHVFIEPYLHEMERQFTLIYDQVQVADISGPRLHNTETYLKEWQLYKGVMADLVYIYIGTAERQMLIYPAWQADANFDPRVRPWYQLASQHVGKMVWTEPYYDYTNGNLVIALARALTDKDGKVRGVFAMDAILAPFPPS
>CP028418.1|AZU45945.1|96828_97248_-|hypothetical-protein
MVVNQSGKVLAHPDTAQLLKPMAHPEWLSRFSQEDGIFLDKASSQFVAYSKLPERNWVLISVQPAASVMAVVERVSLNVQLMVALACVLYVMLALVWSRYFRRMLDEISSMIRASRMQPDDVPQGGCASSDTFMPSWRR
>CP028418.1|AZU45944.1|96262_96871_-|diguanylate-cyclase
MRELRHVYAELAEVSKDYHEARQQANLDKLTGLYNRRFFDERVNRLLFEHQPFCLSMVDLDDFKRVNDTFGHQTGDVVLKRVSKLGMRLLGDHGWVCRYGGEELVVLLVNPDIHFCQMLLEQFRKGVESLDWREPELRITFSGGLVASQAGMDGKTLLEIADAEVYRAKRDGKNRIYLGMPEAKRQEDAPPADDALLSKEEA
>CP028418.1|AZU45943.1|95587_96247_+|hydrolase
MALALFDLDETLIAGDSASLWLAYMVAEELAPASMIAEEQAMMSLYHQGKMDMHQYMAFTLQPLAGKTRQWLDSLCTRFAEQVLRDRIYPEGLARIEWHRQRGDELVLISASGEHLVAPMAQMLGMDHCVAILLDEEAGMLTGQTRGTLSFREGKVARINQLFAASANPWRESHGYSDSHNDLPLLQAVAHPHAVNPAPGLRQIAIEQAWPTLDWQLAS
>CP028418.1|AZU45942.1|94540_95548_+|spermidine/putrescine-ABC-transporter-ATP-binding-protein
MFHLEVNQLHKSYGDTRVFEGIEFGIRKGELVTLLGPSGCGKSTLLRALAGLTPVDGGQVRVAGEDITWQEPQKRGIGMVFQSYALFPNMTVRDNVAFGLKMKPQPGRDLAASVQEALELVELTGFERRYPAELSGGQRQRVALARALVVQPRILLLDEPLSALDARIRRSLRQQIREIQQRLELTTIFVTHDQEEALTMSDRIFLMNKGSIVQSGTPEQIYTRPASEFVASFIGNYNLLDGEQASSLFGPRFQGKLALRPESLTLLPAGARSDEPHLPGVISEQQLLGNVIRYQVSCAAGLLTVDCLNRSAGELLPVGTTVTLVVARDQLCEVA
>CP028418.1|AZU45952.1|102898_103225_-|hypothetical-protein
MYLGKRVGGWLWLALMGGATGTGVAAEPKRAEVGAELVLPLGSLPERVCWYQDQKYSLGARIQQGDSWLECAPQNEQESNGPLAWREPQRASDAAGKATKSGIISVGQ
>CP028418.1|AZU45953.1|103440_104604_+|hypothetical-protein
MRIMPLLQAACLSLMLSACVAPLLMMSPTSQLMWALLKPLVGFDPNEANLFEQPLIKDRMTSILGPNYDSTMQLLKTANELQQEGPLFYVVSRYAPVPDVAKQAGMVWNSQTNQMSVMLLKGDGTPQVFGENLAAGAPSWPTEMQNWQTQGNPATNALTGATNSLTDSATKSLTGAATTSSVFGSVLGSLQQGASKTMADTTKQVVNGAATSVQQQAGKAASSATATVQQATKAVTEPAKQAASNATATVQQQATKAVAEPAKQAVSSATATVQQQATKAVTEPAKQAASSATATVQQATKAVAEPAKQAVSSAAATVQQQATKAVTEPTKQAVSSATATVQQQAAKAVTEPAKQAVSSATATATDAAAKAEAARAAAEAEMEALLK
>CP028418.1|AZU45954.1|104742_105516_+|amino-acid-ABC-transporter-substrate-binding-protein
MSRLLSLMICCCLGTALPASAFTYYSEQNMPFNGQDEQGNSTGLAVELLRLMWQEMGEPEQPIHFMPWAKAWYLLTQQPDAVLFTTAHTQARDPHFLWVCPISHSRVSLVGRKRDAPKVTGKADLTKLQIGVMQADVGEQLLLNRGISPANLMSVERMDQVVRQLIMARTDLVAGNEVMLFHQARQLGFSPDTFVTVATLADQDNCFAFNPAADKQQVARLQQALDKVRQGEAFKRLIARYQDVVQSPPADHLPTIE
>CP028418.1|AZU45955.1|105570_105951_-|hypothetical-protein
MKQFGFFLGIAIGVILILFGSIVIFQALPAALDVLEMPSRIPFVREVYTWLMTSASGLTGQLEQNFLEAFQTVLKLILLITFMWVCVKLVNMGVLIIRAGVDLIRTAIEHSESAQPKKSDHDHHFQ
>CP028418.1|AZU45956.1|106148_107528_+|phosphatidic-acid-phosphatase
MSRYCFLLFCLLLAGLPALAAPGAAVCVVKHQQQLLLVQDRVSSRYSLTGGYIDAGETPQQAALRELYEETGLRGRVIAELGSWQRALLFACQTLEPIRAQTGSGFVSLQRAPNLGGEILNARLIAPARLPDDQRRFPAQLDWLAPQLATIPDSPVLWQPDFRGEGNALHQMEVPLIHQLQTWLGARVRWLAVSNLLGSAAFQLALLPLLLPWLGWPRVRQLLLAMLTLTLLVQVAKEGIGWPRPFHLDPALAQGSAQGFGMPSGHAASALLFWGVLLRRCWPANPWCSSALALLLATLTGLARVWLGVHFLSDVAAGLLLGALLLALHPRLASLAAKSWSWAGLTLVCALAAGWSQSSALAGLATFSLGLTLGMLLPLPRTTQTGWRTPLLVLLGGLPLGALWWELPLWLTSSWLILLGQWLLYCCLGLWLSAGLWWILSLVNNDPLPKGPGPDKGLL
>CP028418.1|AZU45957.1|107524_108610_+|hypothetical-protein
MNMKKVDLAKITLGVLFLSLLIVSCFMVLRPFLPALVWATMITIATWPLMLMVQRLLWGKRALAALSMTLVLLLMFVIPLFMALANVAEKAPMLIELGTTISHSPPPELLWLQQVPLVGGKLYDFWQQILASGGQVLFAKLAPYFGQTARWLASQAGNLGLLFVHFLLTVGICGLLYHSGEVVATGIRRFAHRLAGERGDNATVLASQAIRAVAMGVVVTALVQSSVAGLGLLIAGIPYTMILVVVMFLLIVAQIGPFPVLLACVGYLYWSGDTTWGTFLLVWSLLAGTMDNFLRPFLIKRGADLPLILILVGVIGGLLAMGIIGLFIGPVVLAVGYTLLDAWIKEDDQPAAAAVEAPKAQ
>CP028418.1|AZU45958.1|108614_108746_-|hypothetical-protein
MARISQSDAIAITIAIITITTNNRAALVGGSWYQLWMAESSFY
>CP028418.1|AZU45959.1|108967_109909_-|hypothetical-protein
MVLDIPSKDDFFNMGDSLLNSAWDNLIALLKDYSEYKSVSCEDGFEKAFFLHAKPTLMSSFTLVQQAVEFYLKGKIAEVSPYILISNDSRNWPKAADKSDIDFSEFRTLDAQDLVKIHNTFSETKLDEQFKVWFNEMRNIRNKIMHSVSSQDFIKPTHLAESILTAHSNFFGENQWIRSRFIYHLNSPSNRIEFMTEYEKEGYRYFEIHEEISIAVKALKPSSVEKFFGFNKKAKAMECNFCEEHFENIAFYDHGRWRTHLIDTLVQSDINKHSYTCIICKNTLNVFDAQCVECRNTKINVESGLCVWCKNDL
>CP028418.1|AZU45960.1|110339_111458_-|agmatine-deiminase
MSSRRHVLKQLAALGALVGLGTLPKAKAAATVASSADARFYMPEESTFQTRVWVAFAASEAIWGSDYPAVQATIGRLVQAMVPYTQVNVLCREAEQALARQLCGEQNTRFVVAELDDIWLRDTGGVFVQNEEGELGLVDFNFNGWGDKQEHEQDAGVAELVSQQAKVRYLQSKLTGEGGGIEVDGNGTAILTESCWLNSNRNPGVSKVQLEVELKANLGLRKIIWLPGIKGKDITDAHVDFYARFVRPGVVVVNLDNDPQSHDYEVTRRHLAILKQATDADGNKLELHVLPPPLDGRDNRFSRSRDFAAGYINYLPINGAVIAPEFGDKAADSYCHELLTRLYPGREIVQINIDPVAAGGGGIHCITLHQPA
>CP028418.1|AZU45961.1|111625_112519_+|regulatory-protein-LysR
MVFKQWPPLNVLRGLEAAARLGSFHQAAQALHLTQSAISQQIRSLEELLGQPLFHRQGRSVTLTDAGQDLLETTQSVLLQLAMGIQRLEQYRKPNQLVLNTSSALARHWLLPRLGAFHRAHPEVDLWLFTSDEEPDMAEQTIDLALRWELAPQAECRHQLLLADRLLPVAAPAVLALPATERTTLHGERELDWHHWALKGGEDLQLQTQGLNFSDPGLLLDAACQGLGIALVSERLSRPARQQGQLLPLSTHRVKGPQWHLLVHQESETMPECRAFCRWLELQFADPAPAEDGLPSL

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Crispr_ID: CP028418_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028418_2

179207-179354

Orphan

Consensus_repeat	Method
CCGGTCTGGCCGTTGCGACGACATGGGCAGTAGCACTGCTCGCTGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028418_2

>merge|CP028418|2|179207-179354|CRISPRCasFinder
CCGGTCTGGCCGTTGCGACGACATGGGCAGTAGCACTGCTCGCTGTATGGGGGAACTTCCCCAGACACTTACTCGGCCAGCCAGATAATCGAGGCCATACGACCGGTCTGGCCGTTGCGACGACATGGGCAGTAGCACTGCTCACTGT

>CP028418|2|2|179207-179354|CRISPRCasFinder
CCGGTCTGGCCGTTGCGACGACATGGGCAGTAGCACTGCTCGCTGT	ATGGGGGAACTTCCCCAGACACTTACTCGGCCAGCCAGATAATCGAGGCCATACGA
CCGGTCTGGCCGTTGCGACGACATGGGCAGTAGCACTGCTCACTGT

Protein	Signature genes	Signature genes Name	Protein_function
CP028418.1\|AZU46029.1\|183854_185255_-\|L-cystine-transporter-tcyP	unknown	unknown	gnl\|CDD\|224736
CP028418.1\|AZU46034.1\|191417_192581_-\|aldehyde-reductase	unknown	unknown	gnl\|CDD\|185092
CP028418.1\|AZU46025.1\|179376_180114_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|182677
CP028418.1\|AZU46032.1\|187887_189372_-\|pyridine-nucleotide-transhydrogenase	unknown	unknown	gnl\|CDD\|236520
CP028418.1\|AZU46031.1\|187039_187792_-\|ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270422
CP028418.1\|AZU46021.1\|173725_174187_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|183019
CP028418.1\|AZU46023.1\|175541_176366_-\|metallo-beta-lactamase	unknown	unknown	gnl\|CDD\|293799
CP028418.1\|AZU46016.1\|170506_171022_+\|7,-8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	unknown	unknown	gnl\|CDD\|376515
CP028418.1\|AZU46018.1\|171849_172254_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341392
CP028418.1\|AZU46033.1\|189383_190910_-\|NAD(P)-transhydrogenase-subunit-alpha	unknown	unknown	gnl\|CDD\|236507
CP028418.1\|AZU46024.1\|176426_179000_-\|protein-disaggregation-chaperone	unknown	unknown	gnl\|CDD\|274529
CP028418.1\|AZU46019.1\|172250_172781_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|227700
CP028418.1\|AZU46015.1\|170284_170398_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|341227
CP028418.1\|AZU46028.1\|182431_183760_-\|CoA-disulfide-reductase	unknown	unknown	gnl\|CDD\|181958
CP028418.1\|AZU46017.1\|171024_171729_-\|pteridine-reductase-1	unknown	unknown	gnl\|CDD\|180586
CP028418.1\|AZU46022.1\|174226_175333_+\|asparagine-synthetase-AsnA	unknown	unknown	gnl\|CDD\|235456
CP028418.1\|AZU46030.1\|185420_186713_-\|membrane-protein	unknown	unknown	gnl\|CDD\|226206
CP028418.1\|AZU46026.1\|180433_181414_-\|23S-rRNA-pseudouridine-synthase-D	unknown	unknown	gnl\|CDD\|183020
CP028418.1\|AZU46020.1\|172866_173631_+\|glutamine-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|366132
CP028418.1\|AZU46027.1\|181522_182287_+\|outer-membrane-biogenesis-protein-BamD	unknown	unknown	gnl\|CDD\|274513

Protein	Function_ID	Function_description	E-value
CP028418.1\|AZU46029.1\|183854_185255_-\|L-cystine-transporter-tcyP	gnl\|CDD\|224736	COG1823, COG1823, Predicted Na+/dicarboxylate symporter [General function prediction only].	0
CP028418.1\|AZU46034.1\|191417_192581_-\|aldehyde-reductase	gnl\|CDD\|185092	PRK15138, PRK15138, alcohol dehydrogenase.	0
CP028418.1\|AZU46025.1\|179376_180114_-\|hypothetical-protein	gnl\|CDD\|182677	PRK10723, PRK10723, polyphenol oxidase.	2.79072e-121
CP028418.1\|AZU46032.1\|187887_189372_-\|pyridine-nucleotide-transhydrogenase	gnl\|CDD\|236520	PRK09444, pntB, Re/Si-specific NAD(P)(+) transhydrogenase subunit beta.	0
CP028418.1\|AZU46031.1\|187039_187792_-\|ABC-transporter-substrate-binding-protein	gnl\|CDD\|270422	cd13704, PBP2_HisK, The periplasmic sensor domain of histidine kinase receptors; the type 2 periplasmic binding fold protein. This subfamily includes the periplasmic sensor domain of the histidine kinase receptors (HisK) which are elements of the two-component signal transduction systems commonly found in bacteria and lower eukaryotes. Typically, the two-component system consists of a membrane-spanning histidine kinase sensor and a cytoplasmic response regulator. The two-component systems serve as a stimulus-response coupling mechanism to enable microorganisms to sense and respond to changes in environmental conditions. Extracellular stimuli such as small molecule ligands and ions are detected by the N-terminal periplasmic sensing domain of the sensor kinase receptor, which regulate the catalytic activity of the cytoplasmic kinase domain and promote ATP-dependent autophosphorylation of a conserved histidine residue. The phosphate is then transferred to a conserved aspartate in the response regulator through a phospho-transfer mechanism, and the activity of the response regulator is in turn regulated. The sensor domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space through their function as an initial high-affinity binding component. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.25409e-22
CP028418.1\|AZU46021.1\|173725_174187_-\|transcriptional-regulator	gnl\|CDD\|183019	PRK11179, PRK11179, DNA-binding transcriptional regulator AsnC; Provisional.	1.36867e-111
CP028418.1\|AZU46023.1\|175541_176366_-\|metallo-beta-lactamase	gnl\|CDD\|293799	cd07713, DHPS-like_MBL-fold, Methanocaldococcus jannaschii dihydropteroate synthase, Thermoanaerobacter tengcongensis Tflp, and related proteins; MBL-fold metallo hydrolase domain. This subgroup includes Methanocaldococcus jannaschii 7,8-dihydropterin-6-methyl-4-(beta-D-ribofuranosyl)-aminobenzene-5'-phosphate synthase (EC 2.5.1.15), a folate biosynthetic enzyme also known as dihydropteroate synthase and 7,8 dihydropteroate synthase. Thermoanaerobacter tengcongensis Tflp is a ferredoxin-like member. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	2.61284e-81
CP028418.1\|AZU46016.1\|170506_171022_+\|7,-8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	gnl\|CDD\|376515	pfam01288, HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK).	4.90755e-22
CP028418.1\|AZU46018.1\|171849_172254_+\|hypothetical-protein	gnl\|CDD\|341392	cd04629, CBS_pair_bac, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	2.63639e-56
CP028418.1\|AZU46033.1\|189383_190910_-\|NAD(P)-transhydrogenase-subunit-alpha	gnl\|CDD\|236507	PRK09424, pntA, Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha.	0
CP028418.1\|AZU46024.1\|176426_179000_-\|protein-disaggregation-chaperone	gnl\|CDD\|274529	TIGR03346, chaperone_ClpB, ATP-dependent chaperone ClpB. Members of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (pfam00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins. [Protein fate, Protein folding and stabilization].	0
CP028418.1\|AZU46019.1\|172250_172781_-\|hypothetical-protein	gnl\|CDD\|227700	COG5413, COG5413, Uncharacterized integral membrane protein [Function unknown].	5.38075e-30
CP028418.1\|AZU46015.1\|170284_170398_-\|hypothetical-protein	gnl\|CDD\|341227	PRK14756, small_mem_YnhF, YnhF family membrane protein; Validated.	0.000953006
CP028418.1\|AZU46028.1\|182431_183760_-\|CoA-disulfide-reductase	gnl\|CDD\|181958	PRK09564, PRK09564, coenzyme A disulfide reductase; Reviewed.	0
CP028418.1\|AZU46017.1\|171024_171729_-\|pteridine-reductase-1	gnl\|CDD\|180586	PRK06483, PRK06483, dihydromonapterin reductase; Provisional.	2.74132e-73
CP028418.1\|AZU46022.1\|174226_175333_+\|asparagine-synthetase-AsnA	gnl\|CDD\|235456	PRK05425, PRK05425, asparagine synthetase AsnA; Provisional.	0
CP028418.1\|AZU46030.1\|185420_186713_-\|membrane-protein	gnl\|CDD\|226206	COG3681, COG3681, L-cysteine desulfidase [Amino acid transport and metabolism].	2.04533e-136
CP028418.1\|AZU46026.1\|180433_181414_-\|23S-rRNA-pseudouridine-synthase-D	gnl\|CDD\|183020	PRK11180, rluD, 23S rRNA pseudouridine(1911/1915/1917) synthase RluD.	0
CP028418.1\|AZU46020.1\|172866_173631_+\|glutamine-transporter-substrate-binding-protein	gnl\|CDD\|366132	pfam00497, SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3.	1.03921e-22
CP028418.1\|AZU46027.1\|181522_182287_+\|outer-membrane-biogenesis-protein-BamD	gnl\|CDD\|274513	TIGR03302, OM_YfiO, outer membrane assembly lipoprotein YfiO. Members of this protein family include YfiO, a near-essential protein of the outer membrane, part of a complex involved in protein insertion into the bacterial outer membrane. Many proteins in this family are annotated as ComL, based on the involvement of this protein in natural transformation with exogenous DNA in Neisseria gonorrhoeae. This protein family shows sequence similarity to, but is distinct from, the tol-pal system protein YbgF (TIGR02795). [Protein fate, Protein and peptide secretion and trafficking].	5.41351e-100

>CP028418.1|AZU46024.1|176426_179000_-|protein-disaggregation-chaperone
MRLDRLTSKFQIAISDAQSLALGRDHQFIEPVHLMTALVNQDGGSIRPLLTLTGMDINSLRSRLGEELDRLPRVSGVEGDVQLSNGLGRLLNVCDKLAQQRKDQFISSELFVLAALDEKGTLGELLRAQGLTKEKLEAAIDKVRGGKKVEDANAEENRQALEKYTIDLTERAEIGKLDPVIGRDDEIRRTIQVLQRRTKNNPVLIGAPGVGKTAIVEGLAQRIINGEVPEGLKNKRVLSLDMGALVAGAKYRGEFEERLKAVLNDLAKEEGNVILFIDELHTMVGAGKGEGAMDAGNMLKPALARGDLHCVGATTLDEYRQYIEKDAALERRFQKVLVEEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAAQLSHRYIADRQLPDKAIDLIDEAAASIRLQIDSKPESLDRLERRIIQLKLEQQALMKEDDDASRKRLELINQEINEKDREYNELDEVWKAEKAALAGTQHIKAALEQARQDLDVARRAGDLGRMSELQYGRIPELEKQLDLATQAEMQETSLLRNRVTDVEIADVLARWTGIPVARMLEGERDKLLRMEDQLHSRVIGQEEAVEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKALAEFLFDTQDAMVRIDMSEFMEKHSVARLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNSVVIMTSNLGSDLIQEHHSEKDYDEMKGMLMEVLTRSFRPEFINRIDETVVFHPLGEEHIKSIARIQLKSLMGRLEAQGYEVEVSEALLEKLVHAGFDPVYGARPLKRAIQHKVENPLAQALLSGRIVPGKKLVLGADSNGLTMTQ
>CP028418.1|AZU46023.1|175541_176366_-|metallo-beta-lactamase
MLKFSVLVDDDVHLPGCLPERGLALLLECDGLRVLFDSGRGRALCHNAAVMGIDLASLTHVVLSHGHYDHVGGVGSLPAYPRPIPLIACPDVFCERGYFLSLPFWRRNLYRLSGSLARESLPARGLLPHCSAEPVWLSDRLVFLGSIVRRDRAAPSLLGYIVRGGRVEKDLISDDSALAYKSSKGLIVFIGCGHAGVENIVERAKEVCGDERIHAVIGGLHLKFSGPERAAALGAYLQEEAVEKLFACHCTGGRKAGLPRQRQIGAGFEHSFSA
>CP028418.1|AZU46022.1|174226_175333_+|asparagine-synthetase-AsnA
MYFEEKNTQSLFLLSNIEFSSQSVEESSHPMGSRQVFSMKQHYIRSQQQISFVKEMFSRQLAQQLGLMEVQAPILSRVGDGTQDNLSGHENAVQVKVKTLPEHSYEVVHSLAKWKRQTLGRFGFGPGEGIYTHMKALRPDEDRLTPIHSVYVDQWDWEKVMPSERRDLAYLQETVRGIWAAIKATERAVCAEHELTPFLPAEIQFLHSEELLTRYPDLDAKERERAIAKELGAVFLIGIGGALSHGERHDVRAPDYDDWSSHSELGLAGLNGDILVWNPVLQDSFEISSMGIRVDAEALRRQLAITGDEDRLQYDWHQDLLAARMPQTIGGGIGQSRLAMLLLQKEHIGQVQVGVWPAEMKAAVQGML
>CP028418.1|AZU46021.1|173725_174187_-|transcriptional-regulator
MPENYRIDNLDQAILTALMENARIPYAELAKQLLVSPGTIHVRVEKMKQAGIIEGTRVQVNPKKLGYDVCCFIGINLKSAKDYPSALAKLQALDEVVEAYYTTGHYSIFMKVMTRSIDELQTVLIHKIQTIDEIQSTETLISLQNPILRDVKP
>CP028418.1|AZU46020.1|172866_173631_+|glutamine-transporter-substrate-binding-protein
MRRFILLCLLFPLWLQAKELIIGGTLEPPLKFLDAQGIPHGLDVDVVSTIFGKLRIPIRIELTDSGARLTRNAETGVYDLVMTHSYKPERERYLLYPQQAHLRHSWHFFVRKADLLKIRYDTLADLKPWRIGITKDFSYTPELTAALADPAYHFQEIPINQLQLRKLIAGRIDVVPMPLVTAFAQIKEEGLEGKLDYLPKPLKASPYYTVWTKARADATTPALMAAYDAELLRMKRDGRLKAIYDQYGIPYIEP
>CP028418.1|AZU46019.1|172250_172781_-|hypothetical-protein
MANPEIESELDGIDRVSVCLYRLGLSLAALLLLCRGASLLLGQDFLAPASWLVALASGVCGLCLHVYDKRIRFVLQGLGWGALLLSASGAPDVLVLGAALATLAGLAFKEQFCFAIPGIRAVPLLLPLLWLLELAGIGWAAALVALVCGLLLCLLSLAKWRMPLHFDIGDKGRYQI
>CP028418.1|AZU46018.1|171849_172254_+|hypothetical-protein
MLQIRDHMSRSTHSLTPQLGLAEALDRLHGSGLSGLPVLDPQQRLIGFLSEQDCIPSLLTGSYHCDTRTRVEDLMSRTPLSVSPDDSILDLARQMTEARPKVYPVLEGNRVVGIISRRQVMQALNTQMKGCLPT
>CP028418.1|AZU46017.1|171024_171729_-|pteridine-reductase-1
MRALVTGCGRRLGFYLCEQLVAAGWQVTGSYRSERPELARLRALGVELVQADFAREEEVGKLIEALAVHQDLALVIHNASAFEPQAADPAAQLAQFDQFYRVHMAAPFQLNRALASQLARNANAGIIHITDIYIHAPAPQFASYVATKAGAHSLAMSFARELAPAVRVNTIEPGPILFLDEHGEAWRQQVLAKTPLAREGGLEPIWQAVQLLMQNDYMTGASIRVDGGRGLAVI
>CP028418.1|AZU46016.1|170506_171022_+|7,-8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
MFYLCSIGSNLDPHQHVSQAVGELLVHFGRLQLSSVIQTKPVGMHSSHDFLNCLFVAESELAPHQLKAHFVAMELAHGRDRSDPRCKVLDRPLDIDILASSQSDDFSTARVDAYLDELLAELYGRGQVHDRKVTLPLHTRLMAGKVIEERQVGLAPIALQQEMATPAALLR
>CP028418.1|AZU46015.1|170284_170398_-|hypothetical-protein
MARKEVCMSVELKWALLTASGALAMILIICVASVGLA
>CP028418.1|AZU46025.1|179376_180114_-|hypothetical-protein
MKWIEPDWPAPAKVSALSTTRDGGISEGVFAGLNLGAHVGDEPARVEANRTRLQQAAGIPGTLNWLNQVHGTAVHPVSRDYGCAPDADAACARDAGQACIVMTADCLPVLFCDRAGTVVAAAHAGWRGLQGGVLEVSIAAMGCEPGEILAWLGPAIGPTAFEVGGEVREAFVAEQAAAVAAFVPSPNEGKWLADIYQLARLRLARAGVTAVYGGEYCTFSDSEQFYSYRRNGQTGRMASIIWLAE
>CP028418.1|AZU46026.1|180433_181414_-|23S-rRNA-pseudouridine-synthase-D
MSQHIELTGEFQDHQFGQRLDQALAELFPDYSRTRIKEWILQDRVTLDGQVANTPREKVLAGQKVHVDVELADDTRWDAQNIELNIVYEDEHILVIDKPAGLVVHPGAGTPDGTILNALLHRYPGIAEVPRAGIVHRLDKDTTGLMVVAKTIPAQTHLVEALQARQITREYEAIAIGHMTAGGTVDAPIGRHPTQRTHMAVVPNGRESVTHYRVHEKFRGHTRLRLRLETGRTHQIRVHMAHIKHPLVGDPAYGGRLRLLRNATPELTEALRGFHRQALHATMLKLAHPITGEVMEWHSPTPQDMLDLMEVLRADTLANPDDLVWN
>CP028418.1|AZU46027.1|181522_182287_+|outer-membrane-biogenesis-protein-BamD
MLLMGKKSHLLMSLALVATLITGCSSTKPKVPDEPPETLYQKARLKLDAGNYLNAIELLEALDSRYPFGAYSNQVQLDLIYAYYKQDDTAQAIANIDRFIRLNPAHKNIDYVFYMRGLTNMAGDYNFFQDFLGINRDDKDPSYARQAFQDFKTLLQNYPNSVYAADARARMIGLKNRLARYDLSVAEYYVKRDALIAAANRAKLIVETYPDTAETEKALEIMINSYDSLKMPTLAQHAREVLAKNYPDNRLGRG
>CP028418.1|AZU46028.1|182431_183760_-|CoA-disulfide-reductase
MRIVIIGGEAAGMSAAAKARRLAKEAEIVVYEASEVISFGACGLPYFVGDEFQEPGYMAEFTPEQFAAKGIEVKTGHRVLGLDAAAQTLTVEHKGDTFTDRYDRLMIATGAREVMPPIPGLQQEGVFGLRRMADGLALKAAVQDKANSRALVIGSGFIGLEVVEALVHQGKEVRLIELADRVIPDAFDGEITQHIETELREQGVSLHLGERVEALLGDGRVTGVRTSHGEYEADIVVVCTGVKPNTEFLADTGIERLGNGAIKVDRQGRSSLANVWSAGDCASVWHAVKQQQVYVPLATIANKLGRMVGENLAGAEQEFPGTLGSAALKVLGLEAGRTGLSEQEAKAMGIDYRTVVIKDKCHTNYCPGQSDIHVKLVYEAGSKRLLGGQILGRKGAVHRIDALAVAITMGVTTEQLGMLDFAYAPPFSRTWDVLNVAGNVAK
>CP028418.1|AZU46029.1|183854_185255_-|L-cystine-transporter-tcyP
MTLSVIGNLAILVMLLLFLYRLQQTHVSFTRRVFSGLGLGILFGAALQLLYGAGSDVLVQTGDYLDIVGSGYVKLLQMIITPLIMVSIIGAILKLNGGTALGKISAMTIGVLIFTTMIAAGAGILMSNLFGLTAEGLTAGAAETARGAALQTTLGSVESMSFAKMVLEFIPANPFLDMTGARKTSTIAVVIFSIFVGLSATGIARKKPEIFASFGHFMQVAHVIVMRMVTLVLRLTPYGVLALMTKVVSGSNYADILNLLSFVMASYGAIAIMFAVHLLLVSLVGINPARYLKKIMPVLAFAFTSRTSAGSIPMNVQTQTKALGIPEGIANFAASFGSTIGQNGCAGIYPAMLAVMIAPTVGVNPMDPAFIMTLIAIITVSSFGVAGIGGGATFAALIVLSALDFPVALAGLLISIEPLIDMGRTALNVSGSITAGTVTSRLLGETDMAVFNSEHEVCLDGEESTI
>CP028418.1|AZU46030.1|185420_186713_-|membrane-protein
MKAQWTDFITLLKREVVPALGCTEPMSVALAAANCRKLLGQVPTRVSVWVSGNLFKNGMGVGVPGTGMIGLPVAAAVGITGGNPDAGLEVLKALTPAQVEEAKSLLPAIKVDVKDVPDVLYAEVLAQVEGHSARVVICTDHTRIILMERDGEVLMAQDSAPGVQIQAAPSSKPAMTLREIVEFALQVPLAEIDFIREAATMNQALADEGLQGYGLRIGKILTEQVERKLLSDDLMTLAMRLSSAASDARMDGAMLPAMSNSGSGNQGIAATMPVVAAARFLQASDEQLTRALVMSHLVAIYIKTYQNKLSALCAASTAAMGAGAAITWLLGGQFEQISHCINNMIGDVSGIICDGAGSACSMKVSTSTSAAVKSSLMAINNLHVPQSEGIVSDDVDQTIANLGRLSKQGMLDTDIEIINIMRAKQQGKAE
>CP028418.1|AZU46031.1|187039_187792_-|ABC-transporter-substrate-binding-protein
MVWRKGWILLCLWWGWAAQASEPPTLTLLTELWPPYVMRLDDGSLGGADLELARTVLKRMGYRTTVKVLPWKRVLQEARFQRGDAIVDAFFEERRLEWLHYPDEPLSQSGEVLFFPFARPVDFQGLTSLKGLRIGTQADYAYGEEFLTSSLFTRVAMTGESNMIKQLHLMMAGRLDAVVMNQMVGRYLLKGQGLQEQVGHSEKLVSESNRNFLAFTHRPGNERLAYQFSLALKAFKQTPEYQSLLTRYGL
>CP028418.1|AZU46032.1|187887_189372_-|pyridine-nucleotide-transhydrogenase
MSQGLVTASYIVAAVLFILSLAGLSKQETAKHGNLFGIAGMAIALLATVFNPETSGVHWIILAMVIGGAIGVRLALKVEMTEMPELVAVLHSFVGMAAVLVGFNSFIDLHPSAPAEVVVSVGSNLDATLAAARAAFEQAASIAQVEHLSGAMLNIHLVEIFLGVFIGAVTFTGSVVAFGKLRGLISSKPLMLPHRHKLNLLAVVASLALMVYFVNAGGSTFALLVMTLIAFAFGWHLVASIGGADMPVVVSMLNSYSGWAAAAAGFMLSNDLLIVVGALVGSSGAILSYIMCKAMNRSFISVIAGGFGSDGVASTADQEMGEYRETSAEDVADLLKNSSSVIITPGYGMAVAQAQYPVAEITQKLRDRGVKVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINEDFSDTDTVLVIGANDTVNPAAMEDPGSPIAGMPVLEVWKAQNVIGFKRSMNTGYAGVQNPLFFKENTQMLFGDAKASVEAILKAL
>CP028418.1|AZU46033.1|189383_190910_-|NAD(P)-transhydrogenase-subunit-alpha
MQIGIPRESLAGETRVAATPATVEQLKKLGFEVAIEAGAGLLASFDDAAFEAAGASVVPSVWQADLIFKVNAPTDAEIAQIKDGATLVSFIWPAQNPELVKKLSARNINVMAMDMVPRISRAQSLDALSSMANIGGYRAVVEAAHQFGRFFTGQITAAGKVPPAKVLVIGAGVAGLAAIGTAGSLGAIVRAFDTRLEVAEQIESMGGEFLKLDFGGEDGSSSDGYAKVMSEEFIAAEMALFAQQAKEVDIIITTALIPGKPAPKLITKEMVDSMKPGSVIVDMAAQAGGNCEYTVPGELHVTGNGVKVIGYTDLPGRLPAQSSQLYGTNLVNLMKLMCKEKDGNVAINFEDVVQRNMTVIQAGEVTFPPPAISVSAAPQKPAAAKPAAKKEAAKPSNKKFVFGALGIAAFGWVAAVAPAAFLSHFTVFILACVVGYYVVWNVSHALHTPLMSVTNAISGIIVVGALLQIGQGSTLVTALAFVAVLIASINIFGGFTVTQRMLKMFRKD
>CP028418.1|AZU46034.1|191417_192581_-|aldehyde-reductase
MNNFTLHTPTKILFGKGQVAQLREQLPRDARILITYGGGSVVRSGLLAQIRSELAGMTLFEFGGIEPNPTYETLMGAVELARAERVDFLLAVGGGSVLDGTKFIAAAAHYDPARDPWHILETVGNEVRSAIPLGAVLTLPATGSEMNMGAVVTRRSSGDKVHFFSPFVMPRFAVLDPVLTYTLPARQVANGVVDAFIHILEQYLTYPVNAKVQDRFAEGLLLTLLEEGPKALVEPENYEVRANIMWSATLALNGLIGAGVPQDWATHMLGHEITALHGLDHAQTLAVVLPALLQAKRQQKHAKLLQYAERVWDLRSGSEAERIDGAIAATRDFFERMGIKTRLRDYGVADAGIDTLLGKLAEHGMTAIGEHGDIDLVQSQHIYEAAW

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Crispr_ID: CP028418_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028418_4

1995156-1995260

Orphan

Consensus_repeat	Method
CTTGGAATTTGTCGCTCATATCTTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028418_4

>merge|CP028418|4|1995156-1995260|CRISPRCasFinder
CTTGGAATTTGTCGCTCATATCTTCGCGGCCTTGTTCTGTTCATTCACTGGCAGATATCCGCTGCAGGCCATGATCCGGCCTTGGAATTTGTCGCTCATATCTTC

>CP028418|4|4|1995156-1995260|CRISPRCasFinder
CTTGGAATTTGTCGCTCATATCTTC	GCGGCCTTGTTCTGTTCATTCACTGGCAGATATCCGCTGCAGGCCATGATCCGGC
CTTGGAATTTGTCGCTCATATCTTC

Protein	Signature genes	Signature genes Name	Protein_function
CP028418.1\|AZU47849.1\|1990508_1991153_+\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU47845.1\|1987760_1988084_+\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU47858.1\|1999084_1999390_-\|PTS-sugar-transporter-subunit-IIB	unknown	unknown	gnl\|CDD\|224362
CP028418.1\|AZU47860.1\|1999642_2001049_-\|antiporter	unknown	unknown	gnl\|CDD\|236564
CP028418.1\|AZU47844.1\|1985781_1987764_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|372638
CP028418.1\|AZU47859.1\|1999388_1999511_+\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU47851.1\|1991766_1992897_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225406
CP028418.1\|AZU47862.1\|2004023_2004515_-\|ATPase-AAA	unknown	unknown	gnl\|CDD\|181235
CP028418.1\|AZU47852.1\|1993062_1994433_-\|adenylosuccinate-lyase	unknown	unknown	gnl\|CDD\|236452
CP028418.1\|AZU47856.1\|1997294_1998230_-\|pseudouridine-synthase	unknown	unknown	gnl\|CDD\|211334
CP028418.1\|AZU47861.1\|2001463_2003371_-\|PTS-fructose-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|182066
CP028418.1\|AZU47863.1\|2004536_2005088_-\|acetyltransferase	unknown	unknown	gnl\|CDD\|224584
CP028418.1\|AZU47847.1\|1988923_1989538_+\|glutathione-S-transferase	unknown	unknown	gnl\|CDD\|223698
CP028418.1\|AZU47850.1\|1991185_1991707_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|225695
CP028418.1\|AZU47853.1\|1994559_1995147_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|234690
CP028418.1\|AZU47848.1\|1989525_1990332_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU47855.1\|1996730_1997198_-\|7,8-dihydro-8-oxoguanine-triphosphatase	unknown	unknown	gnl\|CDD\|239647
CP028418.1\|AZU47857.1\|1998316_1999084_-\|PTS-fructose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|334031
CP028418.1\|AZU47854.1\|1995465_1996572_-\|tRNA-2-thiouridylase	unknown	unknown	gnl\|CDD\|234664
CP028418.1\|AZU47846.1\|1988255_1988894_+\|pyridoxamine-5'-phosphate-oxidase	unknown	unknown	gnl\|CDD\|235555

Protein	Function_ID	Function_description	E-value
CP028418.1\|AZU47863.1\|2004536_2005088_-\|acetyltransferase	gnl\|CDD\|224584	COG1670, RimL, Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis].	1.03235e-32
CP028418.1\|AZU47858.1\|1999084_1999390_-\|PTS-sugar-transporter-subunit-IIB	gnl\|CDD\|224362	COG1445, FrwB, Phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism].	3.11113e-40
CP028418.1\|AZU47860.1\|1999642_2001049_-\|antiporter	gnl\|CDD\|236564	PRK09556, uhpT, hexose-6-phosphate:phosphate antiporter.	0
CP028418.1\|AZU47844.1\|1985781_1987764_+\|hypothetical-protein	gnl\|CDD\|372638	pfam13582, Reprolysin_3, Metallo-peptidase family M12B Reprolysin-like. This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	2.26522e-34
CP028418.1\|AZU47851.1\|1991766_1992897_-\|hypothetical-protein	gnl\|CDD\|225406	COG2850, COG2850, Uncharacterized conserved protein [Function unknown].	1.22337e-119
CP028418.1\|AZU47862.1\|2004023_2004515_-\|ATPase-AAA	gnl\|CDD\|181235	PRK08118, PRK08118, DNA topology modulation protein.	4.60813e-19
CP028418.1\|AZU47852.1\|1993062_1994433_-\|adenylosuccinate-lyase	gnl\|CDD\|236452	PRK09285, PRK09285, adenylosuccinate lyase; Provisional.	0
CP028418.1\|AZU47854.1\|1995465_1996572_-\|tRNA-2-thiouridylase	gnl\|CDD\|234664	PRK00143, mnmA, tRNA-specific 2-thiouridylase MnmA; Reviewed.	0
CP028418.1\|AZU47861.1\|2001463_2003371_-\|PTS-fructose-transporter-subunit-IIC	gnl\|CDD\|182066	PRK09765, PRK09765, PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional.	6.59035e-129
CP028418.1\|AZU47847.1\|1988923_1989538_+\|glutathione-S-transferase	gnl\|CDD\|223698	COG0625, Gst, Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones].	1.49659e-45
CP028418.1\|AZU47850.1\|1991185_1991707_+\|acetyltransferase	gnl\|CDD\|225695	COG3153, COG3153, Predicted acetyltransferase [General function prediction only].	1.90965e-50
CP028418.1\|AZU47853.1\|1994559_1995147_-\|hypothetical-protein	gnl\|CDD\|234690	PRK00218, PRK00218, lysogenization regulator HflD.	1.93893e-104
CP028418.1\|AZU47846.1\|1988255_1988894_+\|pyridoxamine-5'-phosphate-oxidase	gnl\|CDD\|235555	PRK05679, PRK05679, pyridoxal 5'-phosphate synthase.	1.99703e-125
CP028418.1\|AZU47857.1\|1998316_1999084_-\|PTS-fructose-transporter-subunit-IIA	gnl\|CDD\|334031	pfam00359, PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2.	2.10399e-18
CP028418.1\|AZU47856.1\|1997294_1998230_-\|pseudouridine-synthase	gnl\|CDD\|211334	cd02566, PseudoU_synth_RluE, Pseudouridine synthase, Escherichia coli RluE. This group is comprised of bacterial proteins similar to E. coli RluE. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. Escherichia coli RluE makes psi2457 in 23S RNA. psi2457 is not universally conserved.	1.72206e-88
CP028418.1\|AZU47855.1\|1996730_1997198_-\|7,8-dihydro-8-oxoguanine-triphosphatase	gnl\|CDD\|239647	cd03675, Nudix_Hydrolase_2, Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which forms a structural motif that functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.64232e-67

>CP028418.1|AZU47853.1|1994559_1995147_-|hypothetical-protein
MAFAGICQAAYLVQKVARDGSCDEAALRESLSSILVTNPSQPLEVFNNTHLAIRDGYRALVEQLGADGSQKNAELTRYVVSLIALERKLAKRKDILNMLGERINQIGRQQQHFDLLDEQILANMASIYSDLISPIGPRIQVAGTPLFLQQPLVQHKVRALLLAGIRACVLWRQLGGSRTQIIFARKKMVELAKRY
>CP028418.1|AZU47852.1|1993062_1994433_-|adenylosuccinate-lyase
MELSALTAVSPIDGRYGDKADALRPIFSEFGLLRFRVEVEVRWLQKLASHAGIPEVPALSAAASALLDGIVQSFNEQDAARIKQIERTTNHDVKAVEYFLKEKVEVNPELAAIAEFIHFACTSEDINNNSHGLMLKTAREEVIKPYCEKLISELKRLAHEYRDMPLLSRTHGQPATPSTMGKEMANVAYRLERQYKQIMAVEILGKINGAVGNYNAHISAYPDVDWHQFSEEFVTSLGLSWNPYTTQIEPHDYIAELFDAMARFNTILIDFDRDVWGYISLGHFKQRTIAGEIGSSTMPHKVNPIDFENSEGNLGLANAVFQHLASKLPISRWQRDLTDSTVLRNLGVAVGYSLIAYQATLKGISKLEANDAAMAADLDANWEVLAEPIQTVMRRYGIEKPYEKLKELTRGRRVDAEGMRTFIDTLELPEAVKVELKKLTPANYIGDAQRLVDLLK
>CP028418.1|AZU47851.1|1991766_1992897_-|hypothetical-protein
MYQLNLDIAHFLEHYWQKRPLLIKGGFTDFQDPISPDELAGLAMEEVIESRLVTRFNNKWEAAHGPFESYDHLGEENWTVLVQACNHWAPEVNELALPFQFIPGWRFDDVMVSFSTPHGGVGPHIDNYDVFITQGQGKRHWRVGDAKPLNEFAAHAALLHCEPFEAIIDVIMEPGDILYIPPGFPHEGYAIEPSLNFSVGFRAPDAKALISSFADHLIDNEVRTERYGDADLKPRARHGEIQSHELHRLRELMQQALDDETLFKEWFGTMISEAKHDLDVNPVEPDYSAEEVADLLTQGEPAIKVPGLRTVWFSGESQQCYIDGEAWTLPSEDAAAISLLCDKDMVTQADMVELADQAGFLQLLTRLVNRGYWFFS
>CP028418.1|AZU47850.1|1991185_1991707_+|acetyltransferase
MLRTERPGDMLPVYDLVSAAFGRSDEAELVNRLRECGAAVVTMVEEEEYEFMGHLMLSPITINGMEGPWLGLAPVAVHPDWQGQGIGSDLVREGLDTALEMDWKAVVVLGDPTYYSRFGFRPASEFGLHCIYEVPADCFMAMELQEGGLTGMQGEVLYHPLFDELPDEAPLEA
>CP028418.1|AZU47849.1|1990508_1991153_+|hypothetical-protein
MVAAILQAGAEEGEPRRLALFLAQLEPESELAVDTLPEQEDDGPLAVEYHDQAVLAQAEPDQLYLYRGLLLKDHDEQGLAYLQQLASLQRQGPAPLTLAERRQRLGWLGTLARRASGENAQGEGVSRRYHQLWLLVELPALIDELAGRWHRGPDQMMSWLEQTDAELFAAYRAAITTLQPSDLQTVLRLLAVRFPESTLPFLDKGAQGGGQFVE
>CP028418.1|AZU47848.1|1989525_1990332_-|hypothetical-protein
MAGGQHRQLQPLKRKGLDQLGGPGRQPVILPGHAHPPGELAIPVQRDHPHQRRLALPRRQGQRPAPAQPERRLAPATGQPVASSLRRVGMGYVEGVAGERRIAAIAHHVGLIARQQGTQLQGRPRLRGGLDQHRHRQTAGQQAVERGAQIVLRRQRQIGALWPQRQQPFLPGQGQQGGRAADEDLAARIPRGLGRQVTIQPGGQQRAGRTHAIGRTTGPESAGVARQTLIGLALQQQPAAALPLPGLQHRRPVGLPQGPLDQQLHQPA
>CP028418.1|AZU47847.1|1988923_1989538_+|glutathione-S-transferase
MRLYGDLKSGNCYKPWLLARWLELPLDWVPVDVLAGETRTPDFLAINPNGKIPVLELAHGDTLAESNAILFYLAQGSPLWPTEPRQQAEVLKWLFFEQYSHEPYIAVARFIVHYLGRPESQEARLDGLKAGGEKALAVLEQQLKQSPYLCGDSPTIADIALYAYTHVAEEGIFSLQGWPAIRAWIARLEAHPRHLSLPAACQAG
>CP028418.1|AZU47846.1|1988255_1988894_+|pyridoxamine-5'-phosphate-oxidase
MMDVADLRREYTRGGLHRADLPAEPLALFEKWLAQACEAKLTDPTAMVVGTVDADGQPWQRTVLLKHYDAEGMVFYTNMGSRKAHQLEGNPRISLLFPWHTLDRQVHVTGRVEKMSTFEVMKYFHSRPKDSQIAAWVSQQSTRISARGVLEAKFLELKQKFANGEVPLPSFWGGFRVRIDTVEFWQGGEHRLHDRFYYTREGQGWHIERLAP
>CP028418.1|AZU47845.1|1987760_1988084_+|hypothetical-protein
MRAGWLVLVSLLGGCQADADTLDQAVSASLAKQDYRLIVRAGRGEVAPGIAPEQQASAKARCGVRYLDGLGDVIKPGQEEAQAKLAAYAADYNRRMLAHCPAVAGKQ
>CP028418.1|AZU47844.1|1985781_1987764_+|hypothetical-protein
MQLMKFSPLALVVASLMSSGGLAAKEWDTVAARASAADGYEVRANQFRVAKVPIDYFTGLQAGARSLTLPLPDGGEVTFTLQAYDLLPADQAAKFPEILTFKGHNPAAPVETGRFDLGPLGFHAMFTHQGKTVFVDPLRNADGYAVYYQQDAYSRLEEDADKVIGSEASRALAHKVQVDGNVRKRYVIAISAAGEYTQFHGGSKVLATAAIATLLNRVNEVYQRDVGAEFQLASGNDNIIFTDPASDPFTNGDADVDINSVVQANAQTLPSAPLGQFDIGHVVNTGGGGLANLGALCTVTRSQGMTGSATPVGDAFFIDYVAHEIGHQFGADHTFNGTTNSCGSGNREATQAWEPGSGTSIMAYAGICGDENIQPHSDPYFHSKSIEQMRAHMATVPACGTTLNLGNNAPQAAAGASRIIPANTPFVLKGAGADLDGDPLTYTWEQIDLGTESSSPATMVDDGSRPLFRFVSPTSSPERILPSLPSLLSGTLAKGEAWPTTNRDLNFRLTVRDGKGGVASDEMKVQVVNTGSAFRLTAPLGVALTPGASQAVSWDVAGTTLAPISCSKVDLFITQNEGSSWSNLAVSQPNSGAATVTLPADLASAARLKVACSDNIFFAISPAKLPVVQSGGSSGGGGGGGALGLWTLALALLGWQRRRG
>CP028418.1|AZU47854.1|1995465_1996572_-|tRNA-2-thiouridylase
MTDNSQIKVIVGMSGGVDSSVSAYLLQQQGYQVEGLFMKNWEEDDTDEYCSAAQDLADAKAVCDKLGMKLHTINFAAEYWDNVFEHFLEEYKAGRTPNPDILCNKEIKFKAFLEFAAEELGATYIATGHYVRRDDSTGRPRLLRGLDTNKDQSYFLYTLSEKQVGQSLFPVGDLEKPEVRRIAEQLDLITAKKKDSTGICFIGERKFKDFLAKFLPAQPGKIETVDGKVIGEHQGLMYHTLGQRKGLGIGGRKDATEEAWYVVDKEVERNVLVVAQGEHPRLYSDGLIASQLHWVDRPPIRAPRRCTVKTRYRQEDIPCLIQPIDDETIRVIFDESQAAVTPGQSAVFYDGEVCLGGGIIEQRFSHPV
>CP028418.1|AZU47855.1|1996730_1997198_-|7,8-dihydro-8-oxoguanine-triphosphatase
MSDHPPLPTRLTVAALVHWQGRFLLVEEEIKGQRRFNQPAGHVEPGEDLIQAACRELKEETGLTAAPTGWLGVYLYKPADSEATFVRTAVIFDLEKAPGQHHPEDPDGDVRACHWLTLAEITECKPALRSPLVWQCIQDYLAGTRLPLSALRAFI
>CP028418.1|AZU47856.1|1997294_1998230_-|pseudouridine-synthase
MKSARPRLSLSARPDAERSASRPAATARPSQRREAQHALRDKEGERKPAPAPADRKLLLLNKPYMVLCQFTDEAGRETLKDYITEPGIYAAGRLDRDSEGLLLLTNDGKLQARLTQPGEKTPKTYWVQVEGVPSEEKLAALRAGVELNDGMTLPAGARIMEEPAVWPRNPPIRERKEIPTCWLEIKIVEGRNRQVRRMTAHIGHPTLRLIRYAIGDWTLDALAPGESRALPAPELAPAPRPAATQGKARTSAKPQGTGSHSAPRAARRPQHQGQEQAPGQGRGSHEAEPRPGHRNGGRGTARRPARSKPSE
>CP028418.1|AZU47857.1|1998316_1999084_-|PTS-fructose-transporter-subunit-IIA
MLIREISFHCRLGLTITQAKQLSRLAGLFKSHIQFINVTRRQAVEATNQLSLLTLATQPGDLCLLLIEGLDAELAHMAFTCWCVELGQPLGRPGSAALAEQRLGQTLPDYCFTLAQLGHATAPLDKAQALAVLVDLLPAALISDRPMLEQAIAAREQLAATIIRPGLAMPHVICPAIHRPALSLLSSSEHIEWGSALGPVQTLILLAVPTGLAPEQLRPLTRLARALMDEQVGTALLHAGSAPARQAIVIDGLLG
>CP028418.1|AZU47858.1|1999084_1999390_-|PTS-sugar-transporter-subunit-IIB
MKILAVTACPTGIAHTYMAAEALQKAADKLGLKIKVETQGAMGLENILTARDIAGADLVLIASDIEIEQKDRFLGCPIHQVALEAVLLDAVAVLKTAAPGV
>CP028418.1|AZU47859.1|1999388_1999511_+|hypothetical-protein
MGSHGKFGWGNKIAPRGGLAKGTEAKMGSRLRSAEGMGKG
>CP028418.1|AZU47860.1|1999642_2001049_-|antiporter
MFKLLEQVRVPTLNLPVEARRKLWFKPFMQSYLVVFIGYLTMYLIRKNFNIAQNDMIQEYGLSMTELGMIGLGFSITYGVGKTIVSYYADGKNTKQFLPLMLILSSLCMLGFSASMGGTGFSLYLMIFFYAASGFFQSCGGSCSYSTITKWTPRNKRGTYLGMWNLSHNVGGAGAAGVALFGANYLFDGNVLGMFIFPSIIALIVGFIGLRFGSDSPEAYGLGKVEELFDEVASEEDIATEEQQLTKWQIFVKYVLMNKVIWLLCFANIFLYVVRIGIDQWSTVYAHQELGFSKEIAIQGFTFFEVGALVGTLMWGYLSDLANGRRGLVACVALALIIATLGLYQHATTQFMFLGSLFLLGFLVFGPQLLIGVAAVGFVPKQGISVADGVKGTFAYLIGDSFAKLGLGMIADGTPIFGLTGWTGTFAALDMAAAACLVLMACVAVAEERKIRRIKRELKAATLATQSA
>CP028418.1|AZU47861.1|2001463_2003371_-|PTS-fructose-transporter-subunit-IIC
MITTLINEQLIALDLKATRKEEVFTEMTRLLAAQGKVSDEQQFIKDLWAREELDNTGFEEGVALPHAKSAAVSTPAVAIGISRAGIEYGAEDGKPSRLFFMIASPAGGANHHIEVLAELSAKLIEEGFIDALLAAKTPTDALALLLEKKEPQVATPAADKGLIIGVTGCPAGIAHTYLAAESLERAAKELGFEVKVETNGSIGVKNSPTAAEIARASAIVVACDKQVDMARFNGKPLIKTGVKAPIKDGKGLIEQALKAPAYVVDKDERKSEEKSSGSSSDLYRYLMNGVSHMIPFVVTGGLLIALALAIGGDPTPSGMQIPAGSMWNQILNVGVAAFTLMIPILAGYIAYAIGDRPALAPGFIGGWIANNGSFYGADAGTGFIGAIIAGLLVGYLVRWIATRHYHKMVQPLVPILIAPIVGSLFIAAVFIFIIGAPIADMMTGLNAMLLSMSGGSLVLLGIVLGGMAGFDMGGPVNKVAFLFSVGMIASGQTQFMGAMACAIPAAPLGMSLATVLGRKLGIFDATEIEAGKAAGAMGLVGISEGAIPFAARDPLAVIPANVLGSMTAAVMAFLFGITNSVAHGGPIVALLGAVNKPLLALLCMICGAIVTGVVAVALKKLRVKKSDEVALAKAA
>CP028418.1|AZU47862.1|2004023_2004515_-|ATPase-AAA
MQRILIIGNSGSGKSWLAARLAEQLTIREVNLDTIVWQPGCFNQKRPQHKIDQAIQTLAQEPSWVVEGVFGALAEQLLDAADTLLFLDLDWSVCRDSLLSRGSQSARQRDAVAAEESFQQLLVWASEYGQRASKSSRQSHRELFDRFPNAKHRFTTREAISRN
>CP028418.1|AZU47863.1|2004536_2005088_-|acetyltransferase
MFKIETTHLILRDMQPTDEAAFVAISQESKYQRFYSESDCDPDKYRQLTKLFIEQANEHPRTAYQLAIEYKATGKFIGTVCLRLEANNQASMGCGMSREYQGNGLINEAAHALLDFGFRTLAVHRVYAETISRNRAAIRLCKTLGMRQEGYFREHRFFKDQWWDTVVLAILQREWQQSSSPAN

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Crispr_ID: CP028418_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028418_5

2236269-2236362

Orphan

Consensus_repeat	Method
TTGGGTGACTTCGAGCTGTGAGT	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028418_5

>merge|CP028418|5|2236269-2236362|CRISPRCasFinder
TTGGGTGACTTCGAGCTGTGAGTCAGCTACCTGAGGTCGGCCAGATCGACAGTGAAGTGAATACCAATGAGTTGGGTGATTTCGAGCTGTGAGT

>CP028418|5|5|2236269-2236362|CRISPRCasFinder
TTGGGTGACTTCGAGCTGTGAGT	CAGCTACCTGAGGTCGGCCAGATCGACAGTGAAGTGAATACCAATGAG
TTGGGTGATTTCGAGCTGTGAGT

Protein	Signature genes	Signature genes Name	Protein_function
CP028418.1\|AZU48109.1\|2241286_2241781_-\|pts-system-mannose-specific-eiiab-component-(eiiab-man)	unknown	unknown	gnl\|CDD\|377139
CP028418.1\|AZU48108.1\|2240470_2241274_-\|PTS-sorbose-transporter-subunit-IIC	unknown	unknown	gnl\|CDD\|377077
CP028418.1\|AZU48097.1\|2227893_2230641_-\|DNA-gyrase-subunit-A	unknown	unknown	gnl\|CDD\|235502
CP028418.1\|AZU48093.1\|2225333_2225510_+\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU48095.1\|2226241_2226364_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU48105.1\|2238096_2238348_+\|Fe-S-protein	unknown	unknown	gnl\|CDD\|225850
CP028418.1\|AZU48094.1\|2225566_2226220_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|276807
CP028418.1\|AZU48111.1\|2242227_2242944_-\|mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|380413
CP028418.1\|AZU48103.1\|2236431_2236677_+\|ferredoxin	unknown	unknown	gnl\|CDD\|182668
CP028418.1\|AZU48101.1\|2232786_2235090_+\|ribonucleotide-diphosphate-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|181649
CP028418.1\|AZU48104.1\|2236794_2237946_-\|murein-transglycosylase	unknown	unknown	gnl\|CDD\|236866
CP028418.1\|AZU48099.1\|2231558_2232302_+\|haloacid-dehalogenase	unknown	unknown	gnl\|CDD\|237310
CP028418.1\|AZU48092.1\|2223401_2225330_-\|threonyl-tRNA-synthetase	unknown	unknown	gnl\|CDD\|234752
CP028418.1\|AZU48096.1\|2226328_2227384_+\|DNA-repair-photolyase	unknown	unknown	gnl\|CDD\|275263
CP028418.1\|AZU48112.1\|2242970_2243993_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|380413
CP028418.1\|AZU48098.1\|2230842_2231559_+\|ubiquinone-biosynthesis-O-methyltransferase	unknown	unknown	gnl\|CDD\|235350
CP028418.1\|AZU48106.1\|2238372_2239530_-\|mannose-6-phosphate-isomerase	unknown	unknown	gnl\|CDD\|225493
CP028418.1\|AZU48100.1\|2232483_2232597_+\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU48107.1\|2239622_2240471_-\|PTS-fructose-transporter-subunit-IID	unknown	unknown	gnl\|CDD\|377079
CP028418.1\|AZU48110.1\|2241790_2242222_-\|PTS-fructose-transporter-subunit-IIA	unknown	unknown	gnl\|CDD\|225446

Protein	Function_ID	Function_description	E-value
CP028418.1\|AZU48109.1\|2241286_2241781_-\|pts-system-mannose-specific-eiiab-component-(eiiab-man)	gnl\|CDD\|377139	pfam03830, PTSIIB_sorb, PTS system sorbose subfamily IIB component.	9.58129e-51
CP028418.1\|AZU48108.1\|2240470_2241274_-\|PTS-sorbose-transporter-subunit-IIC	gnl\|CDD\|377077	pfam03609, EII-Sor, PTS system sorbose-specific iic component.	5.70993e-72
CP028418.1\|AZU48097.1\|2227893_2230641_-\|DNA-gyrase-subunit-A	gnl\|CDD\|235502	PRK05560, PRK05560, DNA gyrase subunit A; Validated.	0
CP028418.1\|AZU48106.1\|2238372_2239530_-\|mannose-6-phosphate-isomerase	gnl\|CDD\|225493	COG2942, COG2942, N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism].	3.31322e-58
CP028418.1\|AZU48105.1\|2238096_2238348_+\|Fe-S-protein	gnl\|CDD\|225850	COG3313, COG3313, Predicted Fe-S protein [General function prediction only].	2.08255e-19
CP028418.1\|AZU48094.1\|2225566_2226220_-\|hypothetical-protein	gnl\|CDD\|276807	sd00010, SLR, Sel1-like repeat. Sel1-like repeats (SLRs) share similar alpha-helical conformations with Tetratricopeptide repeats (TPRs), but with different consensus sequence lengths and superhelical topologies. SLRs contain 36 to 44 amino acids and are present in bacteria and eukaryotes but not in archaea. SLR proteins are involved in a variety of functions, and many serve as adaptor proteins for the assembly of macromolecular complexes. The SLR family was named after the Caenorhabditis elegans Sel1 protein which is predicted to fold into 11 SLRs, a transmembrane domain, and an N-terminal signal sequence. The human Sel1L protein contains an additional fibronectin type-II domain and an N-terminal PEST sequence. Its downregulation is associated with the development of breast and pancreatic carcinomas.	1.08539e-32
CP028418.1\|AZU48111.1\|2242227_2242944_-\|mannose-6-phosphate-isomerase	gnl\|CDD\|380413	cd07010, cupin_PMI_type_I_N_bac, Phosphomannose isomerase in bacteria and archaea, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in many bacteria (e.g. Bacillus subtilis) and archaea. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily does not contain an alpha helical domain that exists in eukaryotic and some prokaryotic PMIs. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death.	1.94819e-38
CP028418.1\|AZU48103.1\|2236431_2236677_+\|ferredoxin	gnl\|CDD\|182668	PRK10713, PRK10713, 2Fe-2S ferredoxin-like protein.	1.40618e-25
CP028418.1\|AZU48101.1\|2232786_2235090_+\|ribonucleotide-diphosphate-reductase-subunit-alpha	gnl\|CDD\|181649	PRK09103, PRK09103, ribonucleoside-diphosphate reductase subunit alpha.	0
CP028418.1\|AZU48104.1\|2236794_2237946_-\|murein-transglycosylase	gnl\|CDD\|236866	PRK11162, mltA, murein transglycosylase A; Provisional.	0
CP028418.1\|AZU48099.1\|2231558_2232302_+\|haloacid-dehalogenase	gnl\|CDD\|237310	PRK13222, PRK13222, N-acetylmuramic acid 6-phosphate phosphatase MupP.	3.68668e-51
CP028418.1\|AZU48092.1\|2223401_2225330_-\|threonyl-tRNA-synthetase	gnl\|CDD\|234752	PRK00413, thrS, threonyl-tRNA synthetase; Reviewed.	0
CP028418.1\|AZU48096.1\|2226328_2227384_+\|DNA-repair-photolyase	gnl\|CDD\|275263	TIGR04470, hypothetical_protein_ALIPUT_00462, radical SAM mobile pair protein B. Members of this family are the downstream member (B) of a pair of tandem-encoded radical SAM enzymes. Most of these radical SAM gene pairs have an additional upstream regulatory gene in the MarR family. Examples of high sequence identity (over 96 percent) from cassettes in several Treponema species of the oral cavity to those in multiple Firmicutes in the gut microbiome suggest recent lateral gene transfer, as might be expected for antibiotic resistance genes. The function is unknown.	1.15483e-21
CP028418.1\|AZU48112.1\|2242970_2243993_-\|hypothetical-protein	gnl\|CDD\|380413	cd07010, cupin_PMI_type_I_N_bac, Phosphomannose isomerase in bacteria and archaea, N-terminal cupin domain. This subfamily contains type I phosphomannose isomerase (PMI; E.C. 5.3.1.8; also known as mannose-6-phosphate isomerase) found in many bacteria (e.g. Bacillus subtilis) and archaea. PMI catalyzes the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P), the first committed step in the synthesis of mannosylated glycoproteins. The active site, located within the N-terminal jelly roll-like beta-barrel cupin fold, contains a single essential zinc atom and forms a deep, open cavity large enough to contain M6P or F6P. PMI type I also has a C-terminal beta-barrel fold which has diverged considerably from the N-terminal domain and is not included here. This subfamily does not contain an alpha helical domain that exists in eukaryotic and some prokaryotic PMIs. F6P is a substrate for glycolysis and gluconeogenesis, while M6P is a substrate for production of activated mannose donor guanosine 5'-diphosphate D-mannose, an important precursor of mannosylated biomolecules such as glycoproteins, bacterial exopolysaccharides and fungal cell wall components. PMI is also essential for survival, virulence and possibly pathogenicity of some bacteria and protozoan parasites, as well as for cell wall integrity of certain yeasts. Thus, PMI is a potential target against fungal infections causing serious illness or death.	0.00776039
CP028418.1\|AZU48098.1\|2230842_2231559_+\|ubiquinone-biosynthesis-O-methyltransferase	gnl\|CDD\|235350	PRK05134, PRK05134, bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG.	1.53986e-162
CP028418.1\|AZU48107.1\|2239622_2240471_-\|PTS-fructose-transporter-subunit-IID	gnl\|CDD\|377079	pfam03613, EIID-AGA, PTS system mannose/fructose/sorbose family IID component.	1.51457e-105
CP028418.1\|AZU48110.1\|2241790_2242222_-\|PTS-fructose-transporter-subunit-IIA	gnl\|CDD\|225446	COG2893, ManX, Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism].	4.20213e-23

>CP028418.1|AZU48101.1|2232786_2235090_+|ribonucleotide-diphosphate-reductase-subunit-alpha
MVFRESTKGHQPMNLFVTKRNGHKEPIDLDKIHRVLDWAAEGLDNVSVSQVELKSHIQFYDGIRTADIHETVIKAAADLISEQSPDYQYMAARLAIFHLRKKAYGQFEPPHLYQHVAKLVDMGKYDKHLLEDYSQAEFEELNQHLDHWRDMDFSYAAVKQLEGKYLVQNRVTGEIYESPQFLYILVAACLFSKYPKDTRLDYIKRFYNAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECDDSLDSINATASAIVRYVSQRAGIGINAGRIRGLGSPIRGGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATLFYPLWHTEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDAPGLYDAFFADQDKFEELYVKYEQDPSIRKKTLKAVDLFSLMMQERAGTGRIYIQNVDHCNTHSPFDPSVAPVRQSNLCLEIALPTKPLNNVDDEDGEIALCTLSAFNLGAIEKLEDLEEMADLAVRALDALLDYQDYPLKAAQKGSMNRRTLGIGVINYAYYLAKNGARYSDGSGLALTHRTFEAIQYYLLKASVQLAREFGPCPAFNETTYAQGILPIDTYKKDLDNLCNEPLHLDWEALREEIRTVGLRNSTLTALMPSETSSQISNATNGIEPPRGLVSVKASKDGILKQVVPEYDRLKDQYELLWKQPSVDGYLQLVGIMQKFVDQAISANTNYDPARFEGNKVPMKQLLKDLLTAYKYGLKTLYYHNTRDGADDAQTDLQDDGCAGGACKI
>CP028418.1|AZU48100.1|2232483_2232597_+|hypothetical-protein
MLVKTPPFRKQKKLFKFSMFDHQTCIYRIGRMKTHSL
>CP028418.1|AZU48099.1|2231558_2232302_+|haloacid-dehalogenase
MTTHSAASLGCVLFDLDGTLLDTAPDLGAAVNHVLISEGFAPLSDDIIRQTTSHGALGLLRAGLGAELLEELGATRLRTALLDYYAANLCVGTRPYEGMVDLIEWLDEKQLPWGIVTNKPGFLTEPLLAALPELASCGVTVSADTLPVRKPDPAPMYFACDQLGVEASHCLYVGITCATSRPAATPACALRSPAGVISMTTRIRPSGAPICILTPCRPCTTGCATSWAEIANPCRSPLVQEADNRDG
>CP028418.1|AZU48098.1|2230842_2231559_+|ubiquinone-biosynthesis-O-methyltransferase
MHSDANVDLTEIAKFEAIASRWWDMEGEFKPLHQINPVRLDWITDKSGGLFGKRILDIGCGGGILAESMARRGAKVTGIDMGKEPLGVARLHALEAGVELEYRQITAEAHADEAPGQYDVVSCMEMLEHVPDPASVLRAIATLVRPGGKVFVSTINRNPKAYLMMILGAEYLMKMVPKGTHDHKKFITPAELCRMGEAAGLLVRDMSGVHYAPLSNSFKLGRNVDVNYMVAFERPEQG
>CP028418.1|AZU48097.1|2227893_2230641_-|DNA-gyrase-subunit-A
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNELGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQDFSMRYMLVDGQGNFGSVDGDSAAAMRYTEVRMARISHELLADLDKETVDWVPNYDGTEMIPAVMPTKVPNLLVNGSSGIAVGMATNIPPHNLTEIVNGCLALIENGDLTIDELMTYITGPDFPTGGIINGRSGIVQAYRTGRGSVYVRAKAEVEVDEKTSRETIIVHEIPYQVNKARLIEKIAELVKEKKIEGISALRDESDKDGMRIVIEIKRGESGEIVLNNLYKHTQMQTTFGINMVALDNNQPKVMNLKEILDAFLLHRREVVTRRTVFELRKARDRAHILEGLAVALANIDPVIELIRHSATPADAKAGLVARGWELGNVASMLEKAGDDAARPEWLEPEFGIREGHYYLTEQQAQAILDLRLHKLTGLEHEKILEEYQSLLDLIAELLFILASPVRLMEVIRDELLAVREQYGDERRTEISMSSAEINIEDLITPEDVVVTLSHQGYVKYQPLSDYEAQRRGGRGKSATRIKEEDFVERLLVANTHDTILCFSTRGKVYWLKVYQLPEASRGARGRPIINLLPLDEGERITAILPVKEYDADKYVFFATANGTVKKTSLSDFSRPLSSGIRAINLKEGDELIGVDITDGSNEIMLFSDAGKVVRFAEGNGRADADATDEVETDDDAGNDDDGSDNGEGTESKGTFKGVRPMGRTAAGVRGIKLGAGDKVVSLIVPRGDGAILTATENGYGKRTALDEYPTKSRGTQGVISIKVDERNGKVIDAIQVEDTDQIMLITNGGTLVRTRVSEVSVIGRNTGGVRLIRTGEDETVVGLQRVAESDEDENEVLAVEGEVSEGTDTAADTGAVDAGEAGDQ
>CP028418.1|AZU48096.1|2226328_2227384_+|DNA-repair-photolyase
MAGRGSSHNVDHRFSGQRVDTVDDGWSQPEWEAAFAASDPRTEVTEISARSIISYNSSPDVPFSRSINPYQGCEHGCIYCYARPSHAYLELSPGLDFETRLFAKLNAAELLRREFARPAYQPQTIVLGANTDPYQPIEHHYRLTRELLTVMLAHRHPVGIITKSAMILRDLDLLTELAREGLCQVMVSVTTLNETLRRQLEPRASTGAGRLKVVEKLAGAGVPVGVLAAPMIPRLNEPELEQIIKGAAEAGAHCADYILLRLPHELAPLFSDWLDEHYPGQKEAILNQLRASRDGALNSPSFGSRMRGEGQFADLLAQRFQLIAKRLGLGKRHFQLRQDAFIRPGEQLRLF
>CP028418.1|AZU48095.1|2226241_2226364_-|hypothetical-protein
MINVVGTASTCHRTLPVLFIYTGIMLTLIAECKPCRPSRP
>CP028418.1|AZU48094.1|2225566_2226220_-|hypothetical-protein
MLDRGATFRLHRRNANWITEIIMAPITSRWLFIAVIALVIWRLIPLSTEQELASANRAWRTGHFDEATRIWSPLAEQGQPRAQALMGWSHEVGQGSEQDISRAITLYRQAAQAGDAFGQYRLGEVYLRGAGVKRDLREAFHWMELAAKNGDVPAMLKVGVLHLMGVSGRVDLPRAKEWLYQAAKQGNQLALKVLQELELAQEGSSTFDFNWQSLLGE
>CP028418.1|AZU48093.1|2225333_2225510_+|hypothetical-protein
MFPYTVVPPTKGHMRDGKIHSKMGDVLALHSTLRRRPATQATRSTSQDKPKTGPCYQK
>CP028418.1|AZU48092.1|2223401_2225330_-|threonyl-tRNA-synthetase
MPIITLPDGSQRQFAHAVSVMDVAADIGPGLAKACIAGRVNGELVDACELIEADASLAIITAKDEEGLDILRHSCAHLLGHAIKQLWPQTKMAIGPVIDNGFYYDIDLDRTLTDEDLAALEERMLALAAKDYDVIKKKVSWQEARDVFEARGETYKVEILDQNIARDDQPGLYHHEEYIDMCRGPHVPNMRHCHHFKLQKMSGAYWRGDSNNKMLQRIYGTAWADKKQLKSYLQRLEEAAKRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELETFIRGKLKEYDYQEVKGPFMMDRVLWERSGHWEKYAQAMFTTQSENREYAIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIMEEVSACIRMVYDVYGTFGFENIVVKLSTRPEQRIGSDEAWDRAEAALAEALVLNGLKYDLQPGEGAFYGPKIEFTLHDCLDRAWQCGTVQLDFALPGRLGATYVGEDNERHVPVMIHRAILGSLERFIGILTEEYAGLFPTWLAPTQAVVMNITDNQADYAVKVAKALNDAGLRAKADLRNEKIGFKIREHTLKRVPFMLVCGDKEVEAGKIAVRTRKGADLGTYPVEELIALLTQEVQTRGQKKVEE
>CP028418.1|AZU48103.1|2236431_2236677_+|ferredoxin
MHTQDGVLHAHPGESVLETLERHGHHVEFQCRSGYCGACRTPLLAGKVHYAAVPLAFVSKGECLPCCCKPVGAIRLDIKKR
>CP028418.1|AZU48104.1|2236794_2237946_-|murein-transglycosylase
MNKHAYWLTAAVLGLAGCAGNSEQAQVPKNKPDARCFLNCEVPENLGKQYLDGPLPDDLVRVERVNSRQRADYSKFGPQSRLVLERSGKMTRRYGELYHQLSRWVANGGDPAQITRYGISLAQLGGSDRMGNVLFTGYYSPVLEVRHRPDAKYKYPIYAMPKCGGRCPSRAQIHQGALANRGLELGYSKSLIDNFLMDVQGSGFVHYGDDDRLQYLGYSGKNGHGYVSIGRVLIDRGEVPKEQMSMKAIKEWANRQPEESVKELVEQNPSYVFFERRPTNDVIGAAGIPLLPMAAVAADKTLLPMGTPILAEVPLLDKEGNWTGKHQLRLLIALDVGGAVKKGHLDLYHGMGEKAGVAAGHYKHFGRVWKLGLHHGPTAAPWL
>CP028418.1|AZU48105.1|2238096_2238348_+|Fe-S-protein
MEQLEIFPLQSPCIGVCEVNNKGYCKGCLRSREERFNWLTMSHAQQQEVMRLCRGRKARVEAARRKAQEGAQPEQPEQAGWDF
>CP028418.1|AZU48106.1|2238372_2239530_-|mannose-6-phosphate-isomerase
MHDEIREAAQRCRRWLVEEALPHWGANGFDWARGLFAEGLDDAGAPLWQPIRFRVQSRQIYVFSHAALLGWYEGGELAERCAKFGMRHFDDGAGNQLFSLNAGGSPADDAVCCYEYAFALLAECWLYRLNGEPRWQQQAESRYQAIELLFADPLYGGFHSRFPASALRSQNPHMHLFEALLVAAECFDESRWQGRAHRLYQLFRQRFLEPALLREFFDERLLPTHPDSRLIDPGHHYEWCWLLARYRALAQGWECGPSEREIAEGIAILTGFAAAHGHGPTGLVLDELTDDGRPHRATSRLWCQTEQLKALLAAYERRGEAETARRIGAVVGRIFDYYLMPALPGQWLDQVDVTGAPLADHAPASTFYHLFVAFSELVRVAQREG
>CP028418.1|AZU48107.1|2239622_2240471_-|PTS-fructose-transporter-subunit-IID
MDAQLQAGQPVNKAPVALTPKDLRACWRAWMMYNLSSMSFERLESFGFCLGMMPALKKLYPGKAERTEAMKRHASFYNTEPQLGAIINGLAVGLEEKRANGERIDGETINTLKVGLMGPIAGIGDSMIPGMLVPILLSIGMALAAGGSVLGPLFYIISFNAIVITGSYMLFMKGYRMGTGSVEALVSSESVKLREALSLLGVFVMGGVAASYVNLSAGLDFVTSDGVNIQLQAMLDGIFPKLMPLLVVLGTWYLMARRNVSPVKAMLGLLVVAFVGVAVGLF
>CP028418.1|AZU48108.1|2240470_2241274_-|PTS-sorbose-transporter-subunit-IIC
MFLEATLIGILCYLGALSSPWLLGLTGGWYTITRPLVSGMLVGAILGDIQTGILIGVAVQAVYIAMVTPGGSMPADLNFVAFPAIALGILSGKEPSVAVAIAATIGIAGTILFNFMMVLNSYWNHRADVALEQGDEQGVYLNSAIFPQASNFVLRFVPTFIAVYFGNQYIEGFMNSLPELVIRTMTVVGGILPAVGIAILLKQIIKQSSMLIYFLVGFVGIVFLKLNMVGLVMIGALLALIHYNYKPEPRPAPAARTATQTDDEDEF
>CP028418.1|AZU48109.1|2241286_2241781_-|pts-system-mannose-specific-eiiab-component-(eiiab-man)
MAISFVRIDDRVIHGQLVTRWARELPCDGIVAIDDEVAADPLLSQVMIGAVPDTRVWLFDVATAIAKLPKVIASDKRYFVIGKSPVTLQRLCAAGISLENHNGKINVGPMSAREQTTTIGPNQSVTAQEIAAFDYLAGLGHDIDFRLVPDASHYSWADAQKKLK
>CP028418.1|AZU48110.1|2241790_2242222_-|PTS-fructose-transporter-subunit-IIA
MLRVLIATHGSLAPALLASASMVYGELPAVATVSLTEEGGIEAFRSEFEQTLRRHGAGTDGVLVLCDMECGTPYNVACRFAFDPEWPQPLAVVTGVNFPMLLMSADLLDAVDVHEAARQLLVQALESMVIAAPAVAHQQDDNF
>CP028418.1|AZU48111.1|2242227_2242944_-|mannose-6-phosphate-isomerase
MHYTQDESYYLLDAKPDACVYLGTRTGIDPQAMLADLAAAQRGEKPFDDERFINRFPARKHDHFLIPAGTVHCSGEGAMVLEISATPYIFTFKLWDWGRVGLDGIPRPIHLAHGSKVIQWERDTDWTREHLVNRIEPIAEGPGWREERTGLHEREFIETRRHWFSVPVEHDTGGTVQVLNLIEGREATVESPDHAFAPFVVHYAETFIVPASVGRYRIRPSGESEGATIATIKAYVRG
>CP028418.1|AZU48112.1|2242970_2243993_-|hypothetical-protein
MIHSSYVSNYDKFPEVVVAGHEGAACAGWHEIARRLQTAVDGKGGARVVLVIDCYHGVDQDELSSQLLARLGPHTLIEVEQARLPESKVLAMLERFITDDRVFGVLAPHKMVEFFDPAALASLQRQVAEITGGLVVVVGSGASLVARGDVRVYADLARWEIQQRLRRKELGNWGAKNEEEDILRRYKRAFFIEWRVFDRHKLTELPTIDFLLDTNTRGKPTLVTGQALLAGLHQAARQPFRVVPFFDPGVWGGQWMKQMCDLDPAQPNYAWCFDCVPEENSLYLRIGEVRVEIPSQNLVLCQPRALLGERVHARFGAEFPIRFDFLDTVGGSRSACRYIR

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Crispr_ID: CP028418_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028418_7

2692529-2692616

Orphan

Consensus_repeat	Method
ATATTGCTGGTGCTGATCAAATC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028418_7

>merge|CP028418|7|2692529-2692616|CRISPRCasFinder
ATATTGCTGGTGCTGATCAAATCAGCCCTCCTGTCGACCGGCCTCACCATCCAGCCTTCCGCGCAATATTGCTGGCGCTGATCAAATC

>CP028418|7|7|2692529-2692616|CRISPRCasFinder
ATATTGCTGGTGCTGATCAAATC	AGCCCTCCTGTCGACCGGCCTCACCATCCAGCCTTCCGCGCA
ATATTGCTGGCGCTGATCAAATC

Protein	Signature genes	Signature genes Name	Protein_function
CP028418.1\|AZU48540.1\|2681740_2682988_-\|folylpolyglutamate-synthase	unknown	unknown	gnl\|CDD\|182774
CP028418.1\|AZU48543.1\|2684974_2686954_-\|pilus-assembly-protein-FimV	unknown	unknown	gnl\|CDD\|274615
CP028418.1\|AZU48545.1\|2687442_2688459_-\|semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
CP028418.1\|AZU48550.1\|2693034_2694909_+\|peptidase-S8	unknown	unknown	gnl\|CDD\|173789
CP028418.1\|AZU48551.1\|2694926_2695385_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|375918
CP028418.1\|AZU48541.1\|2683002_2683866_-\|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-beta	unknown	unknown	gnl\|CDD\|235547
CP028418.1\|AZU48555.1\|2702246_2703059_+\|PEP-synthetase-regulatory-protein	unknown	unknown	gnl\|CDD\|235419
CP028418.1\|AZU48548.1\|2690873_2691704_-\|outer-membrane-lipoprotein	unknown	unknown	gnl\|CDD\|270317
CP028418.1\|AZU48552.1\|2695804_2698186_+\|glycosyl-hydrolase-family-3	unknown	unknown	gnl\|CDD\|185053
CP028418.1\|AZU48547.1\|2690079_2690802_+\|phosphatidylglycerophosphatase	unknown	unknown	gnl\|CDD\|182658
CP028418.1\|AZU48546.1\|2688601_2689732_-\|erythronate-4-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|240635
CP028418.1\|AZU48558.1\|2705425_2706130_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|236840
CP028418.1\|AZU48554.1\|2699559_2701932_-\|phosphoenolpyruvate-synthase	unknown	unknown	gnl\|CDD\|235809
CP028418.1\|AZU48544.1\|2687011_2687137_+\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU48557.1\|2703798_2705175_+\|aromatic-amino-acid-transporter	unknown	unknown	gnl\|CDD\|182324
CP028418.1\|AZU48556.1\|2703148_2703436_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU48553.1\|2698281_2699259_-\|AraC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197666
CP028418.1\|AZU48549.1\|2691940_2692480_+\|isochorismatase-family-protein	unknown	unknown	gnl\|CDD\|238494
CP028418.1\|AZU48559.1\|2706186_2706744_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU48542.1\|2683985_2684795_-\|tRNA-pseudouridine-synthase-A	unknown	unknown	gnl\|CDD\|234577

Protein	Function_ID	Function_description	E-value
CP028418.1\|AZU48540.1\|2681740_2682988_-\|folylpolyglutamate-synthase	gnl\|CDD\|182774	PRK10846, PRK10846, bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional.	0
CP028418.1\|AZU48543.1\|2684974_2686954_-\|pilus-assembly-protein-FimV	gnl\|CDD\|274615	TIGR03505, FimV_core, FimV N-terminal domain. This region is found at, or about 200 amino acids from, the N-terminus of FimV from Pseudomonas aeruginosa, TspA of Neisseria meningitidis, and related proteins. Disruption of FimV blocks twitching motility from type IV pili; Semmler, et al. suggest a role for this family in peptidoglycan layer remodelling required by type IV fimbrial systems. Most but not all members of this protein family have a C-terminal region recognized by TIGR03504. In between is a highly variable, often repeat-filled region rich in the negatively charged amino acids Asp and Glu.	2.37436e-25
CP028418.1\|AZU48545.1\|2687442_2688459_-\|semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	0
CP028418.1\|AZU48550.1\|2693034_2694909_+\|peptidase-S8	gnl\|CDD\|173789	cd04059, Peptidases_S8_Protein_convertases_Kexins_Furin-like, Peptidase S8 family domain in Protein convertases. Protein convertases, whose members include furins and kexins, are members of the peptidase S8 or Subtilase clan of proteases. They have an Asp/His/Ser catalytic triad that is not homologous to trypsin. Kexins are involved in the activation of peptide hormones, growth factors, and viral proteins. Furin cleaves cell surface vasoactive peptides and proteins involved in cardiovascular tissue remodeling in the TGN, at cell surface, or in endosomes but rarely in the ER. Furin also plays a key role in blood pressure regulation though the activation of transforming growth factor (TGF)-beta. High specificity is seen for cleavage after dibasic (Lys-Arg or Arg-Arg) or multiple basic residues in protein convertases. There is also strong sequence conservation.	6.23434e-93
CP028418.1\|AZU48551.1\|2694926_2695385_+\|hypothetical-protein	gnl\|CDD\|375918	pfam18492, ORF_2_N, Open reading frame 2 N-terminal domain. This is the N-terminal domain found in ORF 2 (open reading frame 2), a protein encoded just downstream of asp (A. sobria serine protease). The ORF 2 N-terminal domain is essential for proper ASP folding. This domain is intrinsically disordered but forms some degree of secondary structure upon binding ASP.	1.7008e-30
CP028418.1\|AZU48541.1\|2683002_2683866_-\|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-beta	gnl\|CDD\|235547	PRK05654, PRK05654, acetyl-CoA carboxylase carboxyltransferase subunit beta.	0
CP028418.1\|AZU48555.1\|2702246_2703059_+\|PEP-synthetase-regulatory-protein	gnl\|CDD\|235419	PRK05339, PRK05339, pyruvate, phosphate dikinase/phosphoenolpyruvate synthase regulator.	1.81424e-125
CP028418.1\|AZU48548.1\|2690873_2691704_-\|outer-membrane-lipoprotein	gnl\|CDD\|270317	cd13599, PBP2_lipoprotein_Gna1946, The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold. Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.	6.55567e-133
CP028418.1\|AZU48552.1\|2695804_2698186_+\|glycosyl-hydrolase-family-3	gnl\|CDD\|185053	PRK15098, PRK15098, beta-glucosidase BglX.	5.89599e-66
CP028418.1\|AZU48547.1\|2690079_2690802_+\|phosphatidylglycerophosphatase	gnl\|CDD\|182658	PRK10699, PRK10699, phosphatidylglycerophosphatase B; Provisional.	4.70035e-35
CP028418.1\|AZU48546.1\|2688601_2689732_-\|erythronate-4-phosphate-dehydrogenase	gnl\|CDD\|240635	cd12158, ErythrP_dh, D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains. D-Erythronate-4-phosphate Dehydrogenase (E. coli gene PdxB), a D-specific 2-hydroxyacid dehydrogenase family member, catalyzes the NAD-dependent oxidation of erythronate-4-phosphate, which is followed by transamination to form 4-hydroxy-L-threonine-4-phosphate within the de novo biosynthesis pathway of vitamin B6. D-Erythronate-4-phosphate dehydrogenase has the common architecture shared with D-isomer specific 2-hydroxyacid dehydrogenases but contains an additional C-terminal dimerization domain in addition to an NAD-binding domain and the "lid" domain. The lid domain corresponds to the catalytic domain of phosphoglycerate dehydrogenase and other proteins of the D-isomer specific 2-hydroxyacid dehydrogenase family, which include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-adenosylhomocysteine hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain. Some related proteins have similar structural subdomain but with a tandem arrangement of the catalytic and NAD-binding subdomains in the linear sequence.	0
CP028418.1\|AZU48558.1\|2705425_2706130_-\|hypothetical-protein	gnl\|CDD\|236840	PRK11087, PRK11087, oxidative stress defense protein; Provisional.	7.23205e-82
CP028418.1\|AZU48554.1\|2699559_2701932_-\|phosphoenolpyruvate-synthase	gnl\|CDD\|235809	PRK06464, PRK06464, phosphoenolpyruvate synthase; Validated.	0
CP028418.1\|AZU48557.1\|2703798_2705175_+\|aromatic-amino-acid-transporter	gnl\|CDD\|182324	PRK10238, PRK10238, aromatic amino acid transporter AroP.	0
CP028418.1\|AZU48553.1\|2698281_2699259_-\|AraC-family-transcriptional-regulator	gnl\|CDD\|197666	smart00342, HTH_ARAC, helix_turn_helix, arabinose operon control protein.	9.27537e-19
CP028418.1\|AZU48549.1\|2691940_2692480_+\|isochorismatase-family-protein	gnl\|CDD\|238494	cd01012, YcaC_related, YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.	2.46709e-54
CP028418.1\|AZU48542.1\|2683985_2684795_-\|tRNA-pseudouridine-synthase-A	gnl\|CDD\|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	2.7468e-151

>CP028418.1|AZU48549.1|2691940_2692480_+|isochorismatase-family-protein
MLTTTNTGLLVVDIQGKLARLVEGSDALIANTARLVAGARLLGLPVVWLEQNPDKLGATVPELQLMQAGDLVLPKHSFGALGEPALADALARQGVSHWLVCGIEAHICVYQTVQGLLNAGSQVSLVVDAVSSRSAANRELAINKLAAHGAELTSVEMCLYELLGDCRHPAFRAILALIK
>CP028418.1|AZU48548.1|2690873_2691704_-|outer-membrane-lipoprotein
MQRRSFFALSALALLAGTLPLAALAADPAKQEIVIGTTVGDFADMVTDSIKPQLEAKGYQVKLVEFTDYVTPNIALADGSLDVNCFQHKPYLESFAKDRGLSLAPITQVPTGPMGLYAGKLGELKAVKEGSTVAIPNDPTNQARALLMLQDLGWLTLKEGINPLKASEFDVVKNPHNLKLVLLEAAQLPRSREDVDFSVINGNFAASSGIPFSSGLFLERSYNFINWVVVKSADADKPFAKDVAAAYNSAAFKAYAAKRFVGYKYPEGWQGQSASN
>CP028418.1|AZU48547.1|2690079_2690802_+|phosphatidylglycerophosphatase
MPTHASSLPRRQVLCFSAALILPLLLLACLPWQPFMSQALHSDWLWWPYALTRMVDVPGIAVSILALLLLTRHKLTLSLPALLALGGALFAVLAGDWLIKSLIKHLTEEPRPYLLWLESQQLIPAIQQFYAGKVEVRSEQVHAASQLLALPEWLANHWQAEVNYAFPSGHSIAAMSLAQFFGLIWLARAPAGAWLLPLWAIGVGLSRMLIGMHWPLDVLASALLGSLIALFAARWWLRHY
>CP028418.1|AZU48546.1|2688601_2689732_-|erythronate-4-phosphate-dehydrogenase
MKIVVDENMPHARELFAEFGEVIPLPGRQMQAADLQEADVLLVRSVTRVDAALLASCPRLSFVGTATIGTDHVDKGLLAERGIPFFSAPGCNKYSVGDYVLSALLVLAERHELNLSEMSLAVIGAGNTGECVAGKAEALGMRVLRCDPPRARAAEANEAAQFVDYQQALGADIVSFHVPITHQGPDATFHLLDAAQIAARPAGQILINASRGEVWDNQALLARQQSQAPLRLVMDVWEGEPEPLQALVPHTELATPHIAGYSLEGKARGTWMLYEALCRQLGRRPRQDLQSLLPTPEVREVTPGQPADQALIKQLVHLIYDVRRDDARFRNRLGVAGSFDEQRKHYPERRELSSLQLKGPFAGDALARLGFVCQPD
>CP028418.1|AZU48545.1|2687442_2688459_-|semialdehyde-dehydrogenase
MSQQFNVAVLGASGAVGEAMIEILEERAFPIATLYPLASSRSAGDTVRFAGKNVEILDVEEFDWSQVQIALFSAGAEVSAKWAPIAAEHGCIVIDNTSCFRYDEDIPLVIPEVNPDALADFRNRNIIANPNCSTIQMLVALKPLHDEVGISRINVATYQSVSGSGKEGVSELAGQTAHLLNGRPVEPSLYPQQIAFNLIPQIDSFTDNGYTREEMKMVWETQKILGDASIAVNPTCVRVPVFYGHAEAVHVELHQPLDAEQVKELLRNAPGVTLFDDENDYPTPVRDATGKDEVLVGRVRQDISHPCGINMWIVADNVRKGAATNSVQIAELLVRDYL
>CP028418.1|AZU48544.1|2687011_2687137_+|hypothetical-protein
MCQRLGIDGRRSRLVRAFELNKKRLPRRVFSLGRAQQTQCE
>CP028418.1|AZU48543.1|2684974_2686954_-|pilus-assembly-protein-FimV
MRQVASNAGSYGPIRPTDTLWSLASKYRPSSSVSVYQTMVAIYEKNPRSFADGNINHILVGSRIQLPTTAEASVITDAEARAKFRSDNASWKGLSPKYLASKHTQPAKPVATKAAPTKAAEPAKPEVAKVAPAKAAPIPAPAPKVETPQPATEVKAVAKAPEPVASQAAATSAATASAPAPLPADVNQPVGKPSTEMALALEDANAQLGQVTEMNHRLKLRLQSLTEEVETLKAQLQDQTALQKEIAELKAKPVPPVAPAPEPKQNWLMDLLSSPLNLAMIILLPVLLVLALVTLWLRARARRELEEQEKSLSESTAMVMDQESSEFDELMTVGITDDEPVRPRPDLNTPDGYMAVEEPAAPADLVFSDDGEMDLASFDAEPAPPAKAAIRDPDLVPELDLAHDESITLDSEPDLDLASEFKPKAGNEIMSEEELQAALFAELDADLEADLALDGSDDGQPDADPMVSDEDLASFDLSDFETAFAEPGADKAANATADASADELLAELGLEPEPTKGKQEAAADLEWDPNELALADFEDAFAEVESHPGEVKPREQAQESGYVEIDKLLAEADATTTEQEPYQGFSLDVGLDGFPEVLPESTGFDVDADDGGVGAKLDLARAYLEIDDKDSARELLQEAAEQGTEHQRAEAEKLLKRLG
>CP028418.1|AZU48542.1|2683985_2684795_-|tRNA-pseudouridine-synthase-A
MRIALGIEYDGSRYFGWQRQREVISVQEELEKALSRIANHPVSIQCAGRTDAGVHATGQVIHFDTDANRAEGAWTLGLNSNLPPDIAVRWVKQVDEGFHARFSATARRYRYVIYNHNYRPAILGSGVSHYHETIDADLMHQAGQSLLGEHDFSTFRAVACQSNTPWRNVTHLCVSRSGPYIVLDIKANAFLHHMVRNITGSLLLVGQGLQPVEWIAEVLAARDRNLAGPTAKAGGLYLVDVDYPAELGLPRMPLGPLWLPDSAPGTTSF
>CP028418.1|AZU48541.1|2683002_2683866_-|acetyl-CoA-carboxylase-carboxyl-transferase-subunit-beta
MSWLEKILPKSKITTPRRHNIPEGVWTKCSACEQVLYRAELERNLEVCPKCDHHMRISARARLESFLDEQGRTEIGAELEPQDVLKFKDSKRYKDRLSAAQKETGEKDALVVMKGTLKGVPVVACSFEFSFIGGSMSSVVGARFVRAVEESIKEGRGLVCFSTSGGARMQEALFSLMQMAKTSAALDRLSKAGLPYISVLTDPTMGGVSASLAMLGDINVGEPKALIGFAGPRVIEQTVREKLPEGFQRSEFLLEKGAIDLIIDRREMRNRLASLLAKMLNTHVIEE
>CP028418.1|AZU48540.1|2681740_2682988_-|folylpolyglutamate-synthase
MQQSQSRSLVDWLSYLEQIHPVNIDMGLDRVGAVARRMGLTHLPFKVITVAGTNGKGSSCAMAASILMEAGYQVGVYSSPHLLRFTERVRINGAELADSDHCTAFAEVEAARGEIALTFFEFATLAGLWLFRRAAPDVLLLEVGLGGRLDATNVVESDVAMITSIALDHCDWLGDTREAVAVEKAGVYRAGKPAISGEPNPPVTIASEAARLGACLRQVGIDFHGDEHASGWDYHGLHHWRDLPKPALPLMNAVTVLAALESLGLPLPEEAIRQGLANARLAGRMQQLQSAPLVIVDVAHNPHSAAYLAAQLRKMPCTGVRRAVVGMLKDKDMAGSLAELDGLIGEWYLASLTGLRAASAAQLAAALGSERGPATTFDCVGQAYAAALAASSPDDMVIVFGSFYTVADILAGVAV
>CP028418.1|AZU48550.1|2693034_2694909_+|peptidase-S8
MRKTSLALAISALLSALPIASVQASESCTPLTGKEAGLDTGRSSAARCLPGINPLQDQQWHLLNSGQNAFSPRGGVAGNDLNLWWAHRTGVQGQGINVAVVDDGLAIAHPDLANNMRPGSKNVVTGSSDPTPTDPDSAHGTSVSGLIGAVDNRIGTLGVAPRVQLQGFNLLDERSKQLQKDWIYALGGSTATADNRVFNQSYGMSLVDPQSASGLDQVQLDRLFELQTQQAQGAAYIKAAGNGFNRIAAGDYMFSRTGALPKLPFENSNIDPSNSNFWNLVVSAINADGVRSSYSSVGSNVFLSAPGGEYGTDAPAMVTTDLPGCDMGYNRTDDPSTNRLHNNPQLDVTCDYNGVMNGTSSATPNTSGAMALLMSAYPDLSVRDLRDLLARNATRIDAGQQPVQVSYTAANGQPRQVTGLEGWERNAAGLWYSPTYGFGLIDVNKTLTAATNHTPLPPLVQLPAQKVTVPRSEGSIADVGSSATRSSTQVAQALTVEAVQVTVSLDHQRLPDLLIELVSPSGTRSVLLNPNNSLVGQSLDRQQLGYVRTKGLRDMRMLSHKFYGEAAQGEWRLEVTDVSNSSRQLTLVDLNTNRRSTLTERNNSQPGQLLNWSLRVIGHDAARS
>CP028418.1|AZU48551.1|2694926_2695385_+|hypothetical-protein
MKQSLLGLALAGLLASAGVHAADESVVIDGKQYRTIEVNGQTYLTPDNGSKQRVARSADGKAPRQTLHSGDVLLQGVASPQLTASGTLLVEADDNQASALASRHGLRFKQSSGGIALLEAKPGTDLNAVATALKQEGINVQIELAGALKQPK
>CP028418.1|AZU48552.1|2695804_2698186_+|glycosyl-hydrolase-family-3
MPITTKLKAVSLGVSLALAGLLVGCNQNDSDPLVKDDAYYRGQAEAMVAKLTLGEKLDLLSGPGYGSANGAINVKQDVPGVAGYINGVLRSADGIDIPALKLADGPAGVRINANRDGDSASYYATAWPIGSLLASSWDIKLVKAVGEAMGDEVRQYGVDILLAPGMNIQRNPLNGRNFEYYSEDPLLTGKIGAAMVNGVESNGVGTTIKHYFGNNSETNRNQINDIGEPRTFREIYLRGFQIAVDEAQPWAVMTSYNKVNGTYVNERRDAVTDLLRGEWKFDGLVMSDWFAGDVANNAYKQVLAGQDLIEPGNVKEQLQQSIEHGDLDEAKVNEAAIHILTQVMKSPSYSQLAISNSPDLTAHAKLARQAGAESMVLLRNDAAALPLAASSTLASFGINQINTYKGGTGSGDVNAASTTTIAQGLAARFPVNEALQSYYRDFYENNKVYHEGQFGAKGYYTCAEAPISGDLAALIANAAATQQAAVISIGRQAGEGADRSSGKGDYLLGDDERALIDAVSSAFHAQGKKVVVVLNVNGVIDTAQWSDKVDGILLAYMAGQETGHAVADVLSGAVNPSGKLAQSFPHSYASVPSAGTFPGEDTDGDGEPDDLYYNEGIYVGYRYYSTFEQAVSYPFGFGLSYTSFSYTSPAIASNTLEGGSAGNLVLTATITNTGAVAGKEAAQVYVTAPEVKLKKPLIELKAFAKTAQLAPGASEQLSFTIPASILASFDEASNQWIVEPGRYSAYISPSSDVSASTPVSFTVSKEIVVSNTTPGALALPAGVDPASVTTITR
>CP028418.1|AZU48553.1|2698281_2699259_-|AraC-family-transcriptional-regulator
MLGACQQQGGDPDAILMAGGLTSFDIEREQGRLPAHSHYRMLQLMQPYLASFHETILSYDIGQLYQHYPPLISLCLNQPSPRAALEVLLAYRPIIGSCDELRVRRGAQASQYLYVNQGPASLGASQAIPNFIMLYRILRVYLADPRVSVGFTGRPPPRHQLLDQFFATRCRWEQGENTLTIDNGQLDCPSHCYNEPLGHLQLAQLAQICADIAERAPFAYLVGERIRHKIREGELESDESLLKEVCAAMNVSRWTLNRKLQGEGSSFSTLLREARVSEACRLLGEGDQPLQNISDRVGFSSQSAFNRFFKANTRMTPLAYRNARQ
>CP028418.1|AZU48554.1|2699559_2701932_-|phosphoenolpyruvate-synthase
MQQYVLWYEQLGMQDVERVGGKNASLGEMISNLSGAGVSVPGGFATTAFAFNEFLESSGLNGKIHDLLDSLDVDDIAALNRAGQQIRDWVIEAPFQSALEQAIRVAYDKLSGGLDASFAVRSSATAEDMPDASFAGQQETFLNVRGIDAVMIAVKHVFASLFNDRAISYRVHQGYDHKGVALSAGIQRMVRSDLAASGVMFTLDTESGFNDVVFITGAQGLGEMVVQGAVNPDEFYVHKPTLKAGRPAVVRKTLGSKLIKMTYSGDASHGRQVQIVDTDEAERSRFCITDAEVMELAKQALIIEQHYGRPMDIEWAKDGQDGKLYIVQARPETVRSRQEANTLERFALKQAGKVLIEGRAIGHKIGAGPARVISSISQMDEVQPGDVLVTDMTDPDWEPIMKRASAIVTNRGGRTCHAAIIARELGIPAVVGCGDATKRIEPGQLITVSCAEGDTGFIYDGELDFDVAVTEVGNMPRLPIKIMMNVGNPDRAFDFAQLPNAGVGLARLEFIINRMIGVHPKALLEFDSQSPELKATIGKMIAGYESPREFYVAKLTEGIATLAAAFWPERVIVRMSDFKSNEYANLVGGRDYEPHEENPMIGFRGASRYIADSFRPCFALECEAIKRVRDVMGLTNVEVMIPFVRTVGEAEQVIDILAENGLRRGERGLKVIMMCEIPSNALLADKFLEHVDGFSIGSNDMTQLTLGLDRDSGLIAHLFDERNEAVKALLAMAIAAARKAGKYVGICGQGPSDHPDFAAWLVEQGIDSVSLNPDTVVDTWLYLAEQHKAN
>CP028418.1|AZU48555.1|2702246_2703059_+|PEP-synthetase-regulatory-protein
MHTVFYVSDGTAITAEVFGHAVLSQFPLAFEQITIPFVETLEKARQVRMRIDEQFRQTGVRPILFHTIVDHQVREEVLKAQASSHDFLNTFVSPLEHELGVKAEPRLHRTHGMENRKLYDDRIEAVNFALANDDGITTKEYEEADIILIGVSRCGKTPTSLYLALQFGIRAANYPFIEQDMGVLDLPAALKANRHKLFGLTIAPQRLHEIRNQRRANSRYSSLEQCEQELACVERLFRQEAIRFLDTSSHSVEEISAKILEATGLRRQLY
>CP028418.1|AZU48556.1|2703148_2703436_-|hypothetical-protein
MQRIIGSLLAVALWLTVWLSPLLLTMAAGCLLVWAVQGDDYLVMHLRTVLLIAGAIGLLPALWLTERVRRRHGVLNFYAMLMNNRELNRPGSQPR
>CP028418.1|AZU48557.1|2703798_2705175_+|aromatic-amino-acid-transporter
MDLQQNGEELKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFASGWNYWVLYVLVSMAELTAVGIYVQYWWPEIPTWMSAAFFFVLINAINLSNVKAFGEMEFWFAIIKVVAIIGMIGFGGYLLASGNGGPDASVSNLWAQGGFFPNGISGLVMAMAVIMFSFGGLELVGITAAEADNPEKSIPKATNQVIYRILIFYIGALAVLMSLYPWGKVVEGGSPFVMIFHALDSNLVATVLNMVVLTAALSVYNSCVYCNSRMLFGLAKQGNGPRSLLKTNKSGVPVVAISVSAAATLLCVLINYLMPGKAFELLMALVVSALVINWAMISLAHLKFRKSKQAEGVIPKFKAFWYPFGNYLCLAFMAGILVIMYLTPGIQISVLLIPVWIIVLAIGYQFKQKRQARVAANLG
>CP028418.1|AZU48558.1|2705425_2706130_-|hypothetical-protein
MWRPLLTLSALVISAPLFALEVPQAPHLVVSGYAEQKAEPDMLTLNVSVTALEKQGIKAKQQVDGKVAAFFGQLEGLGIKRSDVEAGNLVISPEYQYPQNKKPELVGYRAQRQLAVKLYQLDKLSELMDTALKAGLESVSQIEYGLKAPQTIKEQARLGAVEDAKTKAESLAKAFGMKLGKVYSVEYRNNSPMPIYSRALKAAAMAPAADMMENSYQQQQITITDNVEAVFLLE
>CP028418.1|AZU48559.1|2706186_2706744_-|hypothetical-protein
MQSFNWVDIDGIRYSWDGQGSITCTGQFGYHATMAGDRIDALDLESDDGEVAGSLNVDFAAATISFTPAFDAAPPHMMVLVGHEQGQQEYTLQSLSDVCLQDLLGHSDNIDCAPLVTTTTTEPVAPLAGHVLSWDSFHFDDDVLLGSRSATPLAAAHQGLPGGEISINIDMTNQVLDQIPPLHDI

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Crispr_ID: CP028418_8

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028418_8

3856914-3857013

Orphan

Consensus_repeat	Method
CCAAAATGTCGAAACGAATGCGGC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028418_8

>merge|CP028418|8|3856914-3857013|CRISPRCasFinder
CCAAAATGTCGAAACGAATGCGGCACCGTACCAACCCGCTTCCAACGCCATGGCCTGATAGCGACTCATGTCACCGCCAACATGTCGAAACGAATGCGGC

>CP028418|8|8|3856914-3857013|CRISPRCasFinder
CCAAAATGTCGAAACGAATGCGGC	ACCGTACCAACCCGCTTCCAACGCCATGGCCTGATAGCGACTCATGTCACCG
CCAACATGTCGAAACGAATGCGGC

Protein	Signature genes	Signature genes Name	Protein_function
CP028418.1\|AZU49665.1\|3848751_3850377_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|381139
CP028418.1\|AZU49663.1\|3847940_3848639_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371478
CP028418.1\|AZU49675.1\|3859206_3859422_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU49669.1\|3853117_3854209_-\|transporter	unknown	unknown	gnl\|CDD\|271367
CP028418.1\|AZU49674.1\|3858598_3859231_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
CP028418.1\|AZU49673.1\|3857178_3858480_-\|major-facilitator-transporter	unknown	unknown	gnl\|CDD\|340888
CP028418.1\|AZU49666.1\|3850410_3851724_-\|transporter	unknown	unknown	gnl\|CDD\|271367
CP028418.1\|AZU49681.1\|3862105_3862648_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
CP028418.1\|AZU49672.1\|3856084_3856906_-\|phosphatase-YbhA	unknown	unknown	gnl\|CDD\|182523
CP028418.1\|AZU49679.1\|3860828_3861254_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
CP028418.1\|AZU49677.1\|3860105_3860423_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225653
CP028418.1\|AZU49682.1\|3862647_3862926_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
CP028418.1\|AZU49668.1\|3852896_3853121_-\|transporter	unknown	unknown	gnl\|CDD\|271367
CP028418.1\|AZU49667.1\|3852179_3852896_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|270422
CP028418.1\|AZU49678.1\|3860568_3860796_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU49670.1\|3854423_3855263_-\|2OG-Fe(II)-oxygenase	unknown	unknown	gnl\|CDD\|226022
CP028418.1\|AZU49671.1\|3855488_3856034_+\|DNA-repair-ATPase	unknown	unknown	gnl\|CDD\|378521
CP028418.1\|AZU49680.1\|3861366_3861843_+\|organic-hydroperoxide-reductase	unknown	unknown	gnl\|CDD\|274649
CP028418.1\|AZU49664.1\|3848619_3848739_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU49676.1\|3859539_3860016_+\|AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439

Protein	Function_ID	Function_description	E-value
CP028418.1\|AZU49665.1\|3848751_3850377_+\|hypothetical-protein	gnl\|CDD\|381139	cd17624, REC_OmpR_PmrA-like, phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators. This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.	0.00405323
CP028418.1\|AZU49663.1\|3847940_3848639_+\|hypothetical-protein	gnl\|CDD\|371478	pfam11340, DUF3142, Protein of unknown function (DUF3142). This bacterial family of proteins has no known function.	1.37317e-14
CP028418.1\|AZU49674.1\|3858598_3859231_+\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	3.21264e-54
CP028418.1\|AZU49673.1\|3857178_3858480_-\|major-facilitator-transporter	gnl\|CDD\|340888	cd17330, MFS_SLC46_TetA_like, Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.27604e-41
CP028418.1\|AZU49666.1\|3850410_3851724_-\|transporter	gnl\|CDD\|271367	cd10336, SLC6sbd_Tyt1-Like, solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain. SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.	1.43061e-166
CP028418.1\|AZU49681.1\|3862105_3862648_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	1.94113e-81
CP028418.1\|AZU49672.1\|3856084_3856906_-\|phosphatase-YbhA	gnl\|CDD\|182523	PRK10530, PRK10530, pyridoxal phosphate (PLP) phosphatase; Provisional.	1.87869e-83
CP028418.1\|AZU49679.1\|3860828_3861254_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.42745e-20
CP028418.1\|AZU49677.1\|3860105_3860423_-\|hypothetical-protein	gnl\|CDD\|225653	COG3111, COG3111, Periplasmic protein with OB-fold [Function unknown].	0.00960974
CP028418.1\|AZU49682.1\|3862647_3862926_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	7.349e-36
CP028418.1\|AZU49668.1\|3852896_3853121_-\|transporter	gnl\|CDD\|271367	cd10336, SLC6sbd_Tyt1-Like, solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain. SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.	1.7946e-11
CP028418.1\|AZU49667.1\|3852179_3852896_+\|hypothetical-protein	gnl\|CDD\|270422	cd13704, PBP2_HisK, The periplasmic sensor domain of histidine kinase receptors; the type 2 periplasmic binding fold protein. This subfamily includes the periplasmic sensor domain of the histidine kinase receptors (HisK) which are elements of the two-component signal transduction systems commonly found in bacteria and lower eukaryotes. Typically, the two-component system consists of a membrane-spanning histidine kinase sensor and a cytoplasmic response regulator. The two-component systems serve as a stimulus-response coupling mechanism to enable microorganisms to sense and respond to changes in environmental conditions. Extracellular stimuli such as small molecule ligands and ions are detected by the N-terminal periplasmic sensing domain of the sensor kinase receptor, which regulate the catalytic activity of the cytoplasmic kinase domain and promote ATP-dependent autophosphorylation of a conserved histidine residue. The phosphate is then transferred to a conserved aspartate in the response regulator through a phospho-transfer mechanism, and the activity of the response regulator is in turn regulated. The sensor domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space through their function as an initial high-affinity binding component. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	3.70068e-16
CP028418.1\|AZU49669.1\|3853117_3854209_-\|transporter	gnl\|CDD\|271367	cd10336, SLC6sbd_Tyt1-Like, solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain. SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.	7.76958e-141
CP028418.1\|AZU49670.1\|3854423_3855263_-\|2OG-Fe(II)-oxygenase	gnl\|CDD\|226022	COG3491, PcbC, Isopenicillin N synthase and related dioxygenases [General function prediction only].	2.73454e-38
CP028418.1\|AZU49671.1\|3855488_3856034_+\|DNA-repair-ATPase	gnl\|CDD\|378521	pfam10973, DUF2799, Protein of unknown function (DUF2799). Some members in this family of proteins are annotated as yfiL which has no known function.	6.01189e-27
CP028418.1\|AZU49680.1\|3861366_3861843_+\|organic-hydroperoxide-reductase	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	4.48076e-57
CP028418.1\|AZU49676.1\|3859539_3860016_+\|AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	3.22775e-48

>CP028418.1|AZU49672.1|3856084_3856906_-|phosphatase-YbhA
MSRFQAIALDMDGTLLTRDHKISSATRAALAQARAHGIKVLLVTGRHFMTARPFHHELALDTPIICSNGAYLYDPVQEQILVGDPLAVAPLSRLLAEVQAHQMGALFHLDEGIGYLGCEEHVTRMRHWSATQPDHLKISLLPAEDLASWLSRPVWKLELFNQDPALLHHFMAEVVEQLPFTRDWAAPYAVELVQPGCSKGNRLAQWAASEGIAMENVVAFGDNNNDISMFEQVGLAVAMGNAASQIQALADRVTADHNEDGIALALQRWVLPA
>CP028418.1|AZU49671.1|3855488_3856034_+|DNA-repair-ATPase
MLTLPFLLAGCSSLSEEECRTMSWYNLGYQDGEQGKTRAATHDYVSTCGEYGLKVDEAEWKRGYAKGLELYCIPELAYSKGKSGAEYQGVCPNDASFLTQYDRGRQEYLVEKQLSDLKSDMERTERDIETLERQIRNENDSKQRDYYRAQRERAIRHYEGLRRDYNRIRFPDRVIQFSFGN
>CP028418.1|AZU49670.1|3854423_3855263_-|2OG-Fe(II)-oxygenase
MKVLTVDYRSPDAAQRFTESLRTTGFGVLTNHPIPKELVQSIYDNWYRFFMSEQKQDFLFNRETQDGYFPPSVSEVAKGHSQKDIKEYFHLYPWGQMPAELKEQAMEYYRLANNLAAELLGWVEQYTPSDIAAHYSCPLSSMIEESQKTLLRVLHYPPFDGTEEPGAIRAAAHEDINLLTILPAANEPGLQVKGSDGEWMDVPCDFGTLIINIGDMLQEASHGYYPSTTHRVINPTGGSAAKSRISLPLFLHPRPDVVLSERHTAHSYLMERLRELGVI
>CP028418.1|AZU49669.1|3853117_3854209_-|transporter
MKQSQWSSRLGYILAAAGSAVGLGAIWKFPYVTAANGGGAFLLVFLLFSFTLGVAVLMGETLLGSLSRRGVVGAFGALMGKRWRWVGAMGLLSSLLIYSFYSVVGGWTLGYTGMALAGSLQHGDGAALTARFNDYVGDPLWPVLTHLLFAGLTWWFVQGGVQKGVERTLRWMMPALFIMILMLVAFGLTLPNAMAGVRHFLMPDFSKLGMSGVLDAMGLAFFSLSIGLGIHTTYGAYLPSSDGVGRSSLWVVLLASLIAVLAGLMIFPVLAATGIDPASGPGLTFMTMPAVFQQLPFGQGLAVVFFALLVVAALSSAISLLEHLQCFVSESLGWSRRAACGLITALVMAGGFRSACRSGPGPR
>CP028418.1|AZU49668.1|3852896_3853121_-|transporter
MTLFGKNIFELLDFVTSNLMMPMFGLALTLLLGWKLGRQALPAGLALHWRTLVMGCWRWLAPLLIGGILVRGLV
>CP028418.1|AZU49667.1|3852179_3852896_+|hypothetical-protein
MKWLLPWLLLPGLAQATQPPLTLLSHELPPFTHTSDGKLGGLAVQLVQEAQQEMGVDYPIKIYPLKRALALTRVEPGFALFVILRTPQREPQFKWVGPLFLNRVVIYQTRGSQPLTDLAQLRQLARVGVLLGNADDELLTREGYTNLVRCQTIEDAIERLILGKIDAFPMGEQIMPAILAKMKFSPRSVVNSGLLLQEHWLYIVFSKSEDDAVIARWQAAIDKVRDRHQQPQQPIRQP
>CP028418.1|AZU49666.1|3850410_3851724_-|transporter
MSQVQWSSRIGHVLAAAGSAIGLGAIWKFPYVTATNGGGAFLLMFLLFSFTLGVAVLVGETLLGSRSQRGVLGAFHKLVGPNWRWMGYMGILCGFFIYSFYSVVGGWTVGYAALAVSGQLNLSEGTALTALFNGYVSHPWWPVLTHLVFAGLTWWFVQGGLQKGVERALRWMMPALFVMMMLLVVTGLSMPGAMAGVRQFLLPDFSMLTGQGVLDALGLAFFSLSIGLGVHTTYGAYLPSSEGVLRSGVWVVTLASLISVLAGLMIFPVLASTGIDPTAGPGLTFMTMPAVFNHLPFGQGLAVVFFLLLLVAALSSSISMLEHLVRFTTEEWGWSRRGACRVLTLLIMASGIPVSLSFGPWSELTLFGKTIFDLLDYLTSNLMMPLFGLVLTLLLGWRLGESVLPAGLSPLLRGCLLWCWRLVAPLLIAGILVRGLL
>CP028418.1|AZU49665.1|3848751_3850377_+|hypothetical-protein
MQILLIEDDAMLSTALSRGLNEQGITPAQLIHCKELATLPTLLRQQSFDVVICRQYHHQTREGVRLLQEAHYLGLLEPGCVLLLLDEDHDQLQFPPSDLYFPLLLPMPFTAEQLTASLRELVQLTGLTRTLSAPMKLREWQVSCALCEDLLYQQQKYRELGPLLDRIKGYMLLQQQDHFHAAQHYAVCTTEHDAWWPRKGLIHALLGLNKLESARKDLARNRERLPAPLQLELALACLLHERQWEGAWDVLTLLLQKQAWQPEWRQAAILLALLLKDEGKALEQANALSLRFFADHKFRVSIENFILNASLAVLWHYPSAARISALQQEYRYLSQTVTLRAHEDALLQALMLSLDYRFDEALLLLAKHPPESARDNHLNQLLGFAVSQFCGLPHHAQRYLNQLSQYQARVAPAPLVQQLFKQVIGDFMKQLERRELRLTYLRQERQRASAAGQHQLAVQYALTLQEEFPALPGDAWQLLELLQLCWPAGMAAPRVALLVDRLERRLNHSASFMEHHAEEYRKTLLQIRSHLNPRLPATPPN
>CP028418.1|AZU49664.1|3848619_3848739_-|hypothetical-protein
MAGSGYGQVWHVAGVKESYHSWSQPAGGQFLPGVRHLAG
>CP028418.1|AZU49663.1|3847940_3848639_+|hypothetical-protein
MMLALLGAEASAAVEASHYRQFWLWAGVRPQPVLQQAERLYLHQGEIGPLDARQPVRFQGQGIAPSKLPVKELWLAYRVERLDWDEALLKSLTNQLAAWQRKGNEVRGVQIDFDARTHRLADYGDFLRQLRRQLPADCAISITGLLDWTRTGDVATLNALAGVVDELVVQTYRGRRTEPGYARYLQALTRLTLPFKVGLVQGGEWDQTWESRLADSAAYGGAVVFLINPPGA
>CP028418.1|AZU49673.1|3857178_3858480_-|major-facilitator-transporter
MIANINKSITLFNGANMEGIKGQASLWVLVMTVTVTVTLAVAGFSLPSPVLAPLMLDPAQGMLTPAASDWSRKVWLGVIMGLYPLFQLVGAPWLGKLSDRHGRKPVLTLCLVGVLVGYALMALGIAWRSLPLLLLSRVVEGFFNGDIAIVQAMAADMSTAKTKARSFAWINIGMNLGWVVGPMIGGYAAVVSGDYSLAAWLAVAMTLVNLLLVFWLLPNRPAAARSEQPAPALSSRQLLLQPALLPYFVLTLLSYGAVQLYFTYFNVWLVERLAWDPVQLAQAAVLVSVPMILGSWLGSRLARHWRGSSLGVAGHLVMAAGMLMFVLPGHWWGLALTFIPTGIGMSLGELATSVAVSNRSHAEQQGQAMGLYRGLAVGSEILAVVVGSLVLLAGTEWPFYLAALCSLLCAIGFYGLRRAADRRQRLDVQIEAG
>CP028418.1|AZU49674.1|3858598_3859231_+|transcriptional-regulator
MNASTDKILFLLKSHGPQSAAELGEQLQMTSMGARQHLMTLEADGWVSFNDEARGRGRPVRLWHLTEQAWQRFPDSHSELTLQLIDNIQQLFGEVGMERLIAQREQQQLARYQAELTQPALADRLADRLAALTAQRTREGYMADYRQEEDGSWLLWESHCPICAAARACRGFCRSELEMFRRLLAPAGVEREQYLLEGDHRCLYRIRPQP
>CP028418.1|AZU49675.1|3859206_3859422_-|hypothetical-protein
MVTSSGGKTETQPGLCGEGPYRVNNPISRLTLSGNDGLEREHPLPEGNKAGIPAPALLFLAFVDQGCGLMR
>CP028418.1|AZU49676.1|3859539_3860016_+|AsnC-family-transcriptional-regulator
MLKLDRIDRHILELMQENGRISNLELAELVGLSPSPCSRRVKALEDAGLIDTHVTLLNARQLGLTLTAYIHISMDRHTPERFENFDRAISELPEVLECDLITGNDADYQLKVVVRDMEHYQHFLLDKLTHIPGVTGVRSSFVLRRIKHKTALPLNHLG
>CP028418.1|AZU49677.1|3860105_3860423_-|hypothetical-protein
MQSSLVGLSILWGLASFGVQGDFIESRDSVAPSWQAESRVEMEGYLIESLGEDRWLFDNGSESLLVSLPQGQWVPTGERLRVSGEPQQEQAGWLLQVQDVSQVAV
>CP028418.1|AZU49678.1|3860568_3860796_-|hypothetical-protein
MRIFLPLFALLLGACSTSSHSPSMAIDDADAWQAICKDGTRVRAVVEEGICADHRGVAMWTNKPRAARMAEEAAK
>CP028418.1|AZU49679.1|3860828_3861254_-|MarR-family-transcriptional-regulator
MSELKKQVCFALYSASNAVMRAYRPLLDKLDLTYTQYLVMLSLWARDEVSLKEIGQETGLDAGTLTPIVKRLESKGWLTRTVSSEDERQKCIGLTEAGRQLQQEVRECCLADNLRNQVDLVDAELAQLKQLCDRISAQLGR
>CP028418.1|AZU49680.1|3861366_3861843_+|organic-hydroperoxide-reductase
MHTNKIRDPDMKTLYRTQAIAQAGRNGEVHTLDNSLQLALALPTALGGNGKGNNPEQLLAAGYAACFSNALIHVAQKLGAPLSSAPVTAGIELLALDDGRFNFAITLDVALAATQPEQAAQAEQIVRLAHQTCPFSNAMRGNVVTRLLLNGAPLDETA
>CP028418.1|AZU49681.1|3862105_3862648_+|NADP-dependent-oxidoreductase
MCPLPLNGPLDGGAIGVVEASRHPDFAVGDRVSSMLGWRDRFVANGAQLTRLPDTRLPPQLFLGALGMPGMTAWTGLNRIAKLQAGETVLVSAASGAVGSMVVQLAKRAGARVIGSTGSADKVAYLKSLGADEVINYRETPDLDAELARLAPDGIHVYFENVGAPCWTPPSTTWWCTVAS
>CP028418.1|AZU49682.1|3862647_3862926_+|NADP-dependent-oxidoreductase
MCGLIEQYNGQSEASGPRNLSQVIRKRLTMQGLIVFDHWQHYGEFLAEVTPAFDAGTLQAEETVYQGLASMPQAFIGLFEGRNTGKMLVKLA

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Crispr_ID: CP028418_9

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028418_9

3863524-3863660

Orphan

Consensus_repeat	Method
CGTTGCTACCTGCCAACCTCGAGCCAGCCGGCACCATAAGCCATCGCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028418_9

>merge|CP028418|9|3863524-3863660|CRISPRCasFinder
CGTTGCTACCTGCCAACCTCGAGCCAGCCGGCACCATAAGCCATCGCCACACCAGCCCACCCCATACCATTGCCTGCTGGCTGGCGAATCGTTGCTACCTGCCAACCTCAAGCCAGCCGGCACCATAAGCCATCGCC

>CP028418|9|9|3863524-3863660|CRISPRCasFinder
CGTTGCTACCTGCCAACCTCGAGCCAGCCGGCACCATAAGCCATCGCC	ACACCAGCCCACCCCATACCATTGCCTGCTGGCTGGCGAAT
CGTTGCTACCTGCCAACCTCAAGCCAGCCGGCACCATAAGCCATCGCC

Protein	Signature genes	Signature genes Name	Protein_function
CP028418.1\|AZU49690.1\|3872443_3873439_+\|glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl\|CDD\|185323
CP028418.1\|AZU49685.1\|3865057_3865450_-\|methionine-sulfoxide-reductase-B	unknown	unknown	gnl\|CDD\|376583
CP028418.1\|AZU49675.1\|3859206_3859422_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU49674.1\|3858598_3859231_+\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|225222
CP028418.1\|AZU49673.1\|3857178_3858480_-\|major-facilitator-transporter	unknown	unknown	gnl\|CDD\|340888
CP028418.1\|AZU49686.1\|3865506_3867648_-\|glycogen-debranching-protein	unknown	unknown	gnl\|CDD\|131155
CP028418.1\|AZU49681.1\|3862105_3862648_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
CP028418.1\|AZU49691.1\|3873554_3874421_+\|aldose-epimerase	unknown	unknown	gnl\|CDD\|185697
CP028418.1\|AZU49692.1\|3874491_3875565_-\|quinolinate-synthetase	unknown	unknown	gnl\|CDD\|236489
CP028418.1\|AZU49682.1\|3862647_3862926_+\|NADP-dependent-oxidoreductase	unknown	unknown	gnl\|CDD\|176190
CP028418.1\|AZU49684.1\|3863825_3864977_+\|chorismate-binding-protein	unknown	unknown	gnl\|CDD\|273350
CP028418.1\|AZU49687.1\|3867647_3869825_-\|glycogen-branching-protein	unknown	unknown	gnl\|CDD\|235445
CP028418.1\|AZU49689.1\|3872100_3872277_+\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU49679.1\|3860828_3861254_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
CP028418.1\|AZU49677.1\|3860105_3860423_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|225653
CP028418.1\|AZU49678.1\|3860568_3860796_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU49680.1\|3861366_3861843_+\|organic-hydroperoxide-reductase	unknown	unknown	gnl\|CDD\|274649
CP028418.1\|AZU49693.1\|3875705_3876884_+\|chemotaxis-protein	unknown	unknown	gnl\|CDD\|350338
CP028418.1\|AZU49688.1\|3869907_3872097_-\|4-alpha-glucanotransferase	unknown	unknown	gnl\|CDD\|236831
CP028418.1\|AZU49676.1\|3859539_3860016_+\|AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439

Protein	Function_ID	Function_description	E-value
CP028418.1\|AZU49690.1\|3872443_3873439_+\|glyceraldehyde-3-phosphate-dehydrogenase	gnl\|CDD\|185323	PRK15425, gapA, glyceraldehyde-3-phosphate dehydrogenase.	0
CP028418.1\|AZU49685.1\|3865057_3865450_-\|methionine-sulfoxide-reductase-B	gnl\|CDD\|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	3.20681e-74
CP028418.1\|AZU49674.1\|3858598_3859231_+\|transcriptional-regulator	gnl\|CDD\|225222	COG2345, COG2345, Predicted transcriptional regulator [Transcription].	3.21264e-54
CP028418.1\|AZU49673.1\|3857178_3858480_-\|major-facilitator-transporter	gnl\|CDD\|340888	cd17330, MFS_SLC46_TetA_like, Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.27604e-41
CP028418.1\|AZU49679.1\|3860828_3861254_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.42745e-20
CP028418.1\|AZU49681.1\|3862105_3862648_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	1.94113e-81
CP028418.1\|AZU49691.1\|3873554_3874421_+\|aldose-epimerase	gnl\|CDD\|185697	cd09020, D-hex-6-P-epi_like, D-hexose-6-phosphate epimerase-like. D-Hexose-6-phosphate epimerase Ymr099c from Saccharomyces cerevisiae belongs to the large superfamily of aldose-1-epimerases. Its active site is very similar to the catalytic site of galactose mutarotase, the best studied member of the superfamily. It also contains the conserved glutamate and histidine residues that have been shown in galactose mutarotase to be critical for catalysis, the glutamate serving as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. In addition Ymr099c contains 2 conserved arginine residues which are involved in phosphate binding, and exhibits hexose-6-phosphate mutarotase activity on glucose-6-P, galactose-6-P and mannose-6-P.	3.33629e-119
CP028418.1\|AZU49692.1\|3874491_3875565_-\|quinolinate-synthetase	gnl\|CDD\|236489	PRK09375, PRK09375, quinolinate synthase NadA.	0
CP028418.1\|AZU49682.1\|3862647_3862926_+\|NADP-dependent-oxidoreductase	gnl\|CDD\|176190	cd05288, PGDH, Prostaglandin dehydrogenases. Prostaglandins and related eicosanoids are metabolized by the oxidation of the 15(S)-hydroxyl group of the NAD+-dependent (type I 15-PGDH) 15-prostaglandin dehydrogenase (15-PGDH) followed by reduction by NADPH/NADH-dependent (type II 15-PGDH) delta-13 15-prostaglandin reductase (13-PGR) to 15-keto-13,14,-dihydroprostaglandins. 13-PGR is a bifunctional enzyme, since it also has leukotriene B(4) 12-hydroxydehydrogenase activity. These 15-PGDH and related enzymes are members of the medium chain dehydrogenase/reductase family. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES.	7.349e-36
CP028418.1\|AZU49684.1\|3863825_3864977_+\|chorismate-binding-protein	gnl\|CDD\|273350	TIGR00937, Chromate_transport_protein, chromate transporter, chromate ion transporter (CHR) family. Members of this family probably act as chromate transporters, and are found in Pseudomonas aeruginosa, Alcaligenes eutrophus, Vibrio cholerae, Bacillus subtilis, Ochrobactrum tritici, cyanobacteria and archaea. The protein reduces chromate accumulation and is essential for chromate resistance. [Transport and binding proteins, Anions].	1.55537e-66
CP028418.1\|AZU49687.1\|3867647_3869825_-\|glycogen-branching-protein	gnl\|CDD\|235445	PRK05402, PRK05402, 1,4-alpha-glucan branching protein GlgB.	0
CP028418.1\|AZU49686.1\|3865506_3867648_-\|glycogen-debranching-protein	gnl\|CDD\|131155	TIGR02100, Glycogen_operon_protein_GlgX_homolog, glycogen debranching enzyme GlgX. This family consists of the GlgX protein from the E. coli glycogen operon and probable equivalogs from other prokaryotic species. GlgX is not required for glycogen biosynthesis, but instead acts as a debranching enzyme for glycogen catabolism. This model distinguishes GlgX from pullanases and other related proteins that also operate on alpha-1,6-glycosidic linkages. In the wide band between the trusted and noise cutoffs are functionally similar enzymes, mostly from plants, that act similarly but usually are termed isoamylase. [Energy metabolism, Biosynthesis and degradation of polysaccharides].	0
CP028418.1\|AZU49677.1\|3860105_3860423_-\|hypothetical-protein	gnl\|CDD\|225653	COG3111, COG3111, Periplasmic protein with OB-fold [Function unknown].	0.00960974
CP028418.1\|AZU49680.1\|3861366_3861843_+\|organic-hydroperoxide-reductase	gnl\|CDD\|274649	TIGR03561, organ_hyd_perox, peroxiredoxin, Ohr subfamily. pfam02566, OsmC-like protein, contains several deeply split clades of homologous proteins. The clade modeled here includes the protein Ohr, or organic hydroperoxide resistance protein. [Cellular processes, Detoxification].	4.48076e-57
CP028418.1\|AZU49693.1\|3875705_3876884_+\|chemotaxis-protein	gnl\|CDD\|350338	cd12913, PDC1_MCP_like, first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains. Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Methyl-accepting chemotaxis proteins (MCPs), Histidine kinases (HKs), and other similar domains. Many members contain both HAMP (HK, Adenylyl cyclase, MCP, and Phosphatase) and MCP domains, which are signalling domains that interact with protein partners to relay a signal. MCPs are part of a transmembrane protein complex that controls bacterial chemotaxis. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.	4.96368e-22
CP028418.1\|AZU49688.1\|3869907_3872097_-\|4-alpha-glucanotransferase	gnl\|CDD\|236831	PRK11052, malQ, 4-alpha-glucanotransferase; Provisional.	0
CP028418.1\|AZU49676.1\|3859539_3860016_+\|AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	3.22775e-48

>CP028418.1|AZU49682.1|3862647_3862926_+|NADP-dependent-oxidoreductase
MCGLIEQYNGQSEASGPRNLSQVIRKRLTMQGLIVFDHWQHYGEFLAEVTPAFDAGTLQAEETVYQGLASMPQAFIGLFEGRNTGKMLVKLA
>CP028418.1|AZU49681.1|3862105_3862648_+|NADP-dependent-oxidoreductase
MCPLPLNGPLDGGAIGVVEASRHPDFAVGDRVSSMLGWRDRFVANGAQLTRLPDTRLPPQLFLGALGMPGMTAWTGLNRIAKLQAGETVLVSAASGAVGSMVVQLAKRAGARVIGSTGSADKVAYLKSLGADEVINYRETPDLDAELARLAPDGIHVYFENVGAPCWTPPSTTWWCTVAS
>CP028418.1|AZU49680.1|3861366_3861843_+|organic-hydroperoxide-reductase
MHTNKIRDPDMKTLYRTQAIAQAGRNGEVHTLDNSLQLALALPTALGGNGKGNNPEQLLAAGYAACFSNALIHVAQKLGAPLSSAPVTAGIELLALDDGRFNFAITLDVALAATQPEQAAQAEQIVRLAHQTCPFSNAMRGNVVTRLLLNGAPLDETA
>CP028418.1|AZU49679.1|3860828_3861254_-|MarR-family-transcriptional-regulator
MSELKKQVCFALYSASNAVMRAYRPLLDKLDLTYTQYLVMLSLWARDEVSLKEIGQETGLDAGTLTPIVKRLESKGWLTRTVSSEDERQKCIGLTEAGRQLQQEVRECCLADNLRNQVDLVDAELAQLKQLCDRISAQLGR
>CP028418.1|AZU49678.1|3860568_3860796_-|hypothetical-protein
MRIFLPLFALLLGACSTSSHSPSMAIDDADAWQAICKDGTRVRAVVEEGICADHRGVAMWTNKPRAARMAEEAAK
>CP028418.1|AZU49677.1|3860105_3860423_-|hypothetical-protein
MQSSLVGLSILWGLASFGVQGDFIESRDSVAPSWQAESRVEMEGYLIESLGEDRWLFDNGSESLLVSLPQGQWVPTGERLRVSGEPQQEQAGWLLQVQDVSQVAV
>CP028418.1|AZU49676.1|3859539_3860016_+|AsnC-family-transcriptional-regulator
MLKLDRIDRHILELMQENGRISNLELAELVGLSPSPCSRRVKALEDAGLIDTHVTLLNARQLGLTLTAYIHISMDRHTPERFENFDRAISELPEVLECDLITGNDADYQLKVVVRDMEHYQHFLLDKLTHIPGVTGVRSSFVLRRIKHKTALPLNHLG
>CP028418.1|AZU49675.1|3859206_3859422_-|hypothetical-protein
MVTSSGGKTETQPGLCGEGPYRVNNPISRLTLSGNDGLEREHPLPEGNKAGIPAPALLFLAFVDQGCGLMR
>CP028418.1|AZU49674.1|3858598_3859231_+|transcriptional-regulator
MNASTDKILFLLKSHGPQSAAELGEQLQMTSMGARQHLMTLEADGWVSFNDEARGRGRPVRLWHLTEQAWQRFPDSHSELTLQLIDNIQQLFGEVGMERLIAQREQQQLARYQAELTQPALADRLADRLAALTAQRTREGYMADYRQEEDGSWLLWESHCPICAAARACRGFCRSELEMFRRLLAPAGVEREQYLLEGDHRCLYRIRPQP
>CP028418.1|AZU49673.1|3857178_3858480_-|major-facilitator-transporter
MIANINKSITLFNGANMEGIKGQASLWVLVMTVTVTVTLAVAGFSLPSPVLAPLMLDPAQGMLTPAASDWSRKVWLGVIMGLYPLFQLVGAPWLGKLSDRHGRKPVLTLCLVGVLVGYALMALGIAWRSLPLLLLSRVVEGFFNGDIAIVQAMAADMSTAKTKARSFAWINIGMNLGWVVGPMIGGYAAVVSGDYSLAAWLAVAMTLVNLLLVFWLLPNRPAAARSEQPAPALSSRQLLLQPALLPYFVLTLLSYGAVQLYFTYFNVWLVERLAWDPVQLAQAAVLVSVPMILGSWLGSRLARHWRGSSLGVAGHLVMAAGMLMFVLPGHWWGLALTFIPTGIGMSLGELATSVAVSNRSHAEQQGQAMGLYRGLAVGSEILAVVVGSLVLLAGTEWPFYLAALCSLLCAIGFYGLRRAADRRQRLDVQIEAG
>CP028418.1|AZU49684.1|3863825_3864977_+|chorismate-binding-protein
MGQVFMQFLWLGCISFGGPAAHIGYFQRTFVERLGWLTQAEFAQLLALCQLLPGPASSQLGFAIGRQRAGLGGALAAFAGFTLPSFLLLLAAAIGLGQLGNNVWLDAALHGLKLLALVVVADAVLTMSRQFCKTTRNQGIMVATAAALWWQPGLLTQLVMLAGAALLCARVGAPQTPGPQPSPAQSIPVRQPHWPTLLLFALLFVGLPLLGGPVGQLVTDFYRAGSLVFGGGHVVLPLLAESVGHSLNQQQFLTGYSLAQLVPGPMFTLATYLGAQLLPASPVGGALLATLALFLPGFLLLWAMGPCWQSWLARPRLAGTVAGINAAVVGLLLAALYQPVWQSAVLAPTDLALAAIGFYLLRVLKLPILALATLLVVATLLLA
>CP028418.1|AZU49685.1|3865057_3865450_-|methionine-sulfoxide-reductase-B
MSGNTPNPEQWRRQLSAEQYHVCWEKGTERPYSGALLHNRKSGDYLCVCCKQVLFHSDAKFDSGCGWPSFDRAIEGTVTYTEDGSHGMKRVEITCSQCGSHLGHVFPDGPTETGQRYCVNSLSLDFDPEP
>CP028418.1|AZU49686.1|3865506_3867648_-|glycogen-debranching-protein
MFAMEKGQDHPLGALLDETGCHFCVWAPQSDKVELCLFDEQERELARLELPGRRGQYRFGHVRGVKAGQRYGYRVHGTSQEGMLFDPDKLLIDPYAKALSRPTHWDDALYQGDSAAMVAKSVVVDDAFDWQGVGKPAIEPARTVIYETHVKGFTRQHQGVPSELRGTYLGICHPLIIEHLKSLGITSVQLMPVAAFMSEPRLEQLGLTNYWGYNPIAFFAPEPRYAAQEAVTEFKTMVRELHKAGLEVILDVVYNHTAESGFDGPMLSFKGFDNAGYYAFEAGAHGPDYTRHANVTGCGNSVNLDHPNSLRLVLDALRYWVTEMQVDGFRFDLAVTLAREAGEFDPMGAFFKAMMADPVLARVKLIAEPWDIGPFGYRLGQFPSQWLEINDRYRDTVRAFWRGDAGKMGDFATRLVGSRDLFPKNWRSPHTSVNYLCYHDGFTLEDLVSYNQRHNQANGEDNRDGHGNNLSNNHGVEGPTLDPRVNNLRQQQKRNLIATLLLSQGTPHFLAGDEMGRSQLGNNNAYCQDNQISWVNWQWRPEDERLLAFTQQMLALRAESTVFSNLQLSDDSWNGAPSSCHQVNWYHPDGHQLTDQDWHAPMGQAFAMDIGMIGCGGERWYVLFNASDYDIQFRLPPPGEGLEWIQTIDTATNDGLPFLPDDIKRQVAVGRAHSLKLLERVALSAVALAEEGVVATPDVAVVLPSGSQFPLAG
>CP028418.1|AZU49687.1|3867647_3869825_-|glycogen-branching-protein
MLVERLVAARCSDPFSHLGLQANPDGPGLKLTVWLPDAQAVRVRDLKSGKIVATLAPTDDSGLFETVFTRRKNPFPYQLLADYPDASVEVIDPYQFQDAGWAGLAELTYQPENLYHTLGAQLRTVEHLDQQVEGVRFAVYAPSATAVSLIGDFNFWDGRRHPMQRSQCGHWVLFVPGLKAGDRYKFELKDPAGNRLPHKSDPVGFYCEQYPSFASVVYDHDQYQWQDAAWRESQLNDKREQPLSIYELHVGSWKRHPNGDSLSWRELAVELVDYVKGMEYTHIELLPVSEHPFSGSWGYQPVGMFSPTSRYGTADDFKYFVDQCHQAGIGVILDWVPAHFPSDAHGLARFDGTPLYEYEDPRRGWHPDWNSYIYDFGRNTVRQFLVASALFWLDKFHVDGLRVDAVASMLYLDYSRNAGEWVPNVDGGNHNYEAISLLKWTNEEVYGKYPHAMTIAEESTAFAGVSRPTFLGGLGFGFKWNMGWMHDTLTYMQKEPIHRRYHHNDMTFSMVYHYDENFILSLSHDEVVHGKHSMLYKMPGDEWQQAANLRAYMGFMYAHPGKKLNFMGTEIAQSNEWNHDAQLPWHLLQYPKHGGQQRLIHDLNHLYRHEPALYQADYEQNGFRWLDHNDADNSIFAWLRADKQGANPLVVACNFTPVPRLAYRLGVPAAGHYRVVLNTDSEHYWGSNYDVGLVFAAEPTPWQGMAHSIVLDLPPLATLFIKQES
>CP028418.1|AZU49688.1|3869907_3872097_-|4-alpha-glucanotransferase
MTTLIEQLAAAKGIASEYVDAWGHPAQVSEESKAAMLGAMGYRVDDEAALTEQLEQEHHQHWLRALDPVMVVRSGEPITLEVRLPIEFVNDALSWQLKLEQGGVLSGQLTPIDGELVGVAEFEEMECQAYRVALAVQPELGYHDLILLEEDNDEPLASMRLIVAPKACYKQPPIANGRKVWGPSVQLYCLRSRHNWGIGDFSDLGQLVEKMAAWGAHFVGLNPIHALYPANPESASPYSPSSRRWLNVAYIDVEAVPEFLANARLKAEVANPAFQQHLSELRAKGNVDYTGVVETKLGMLRQVFDQASLSAERQAAFDAFVAAGGDSLQQQAAFDALQAHFYAKGENAWGWPVWPEPFRDYHNPEVAAWMAEHSQDVNFYLYLQFLADEQLARADARAKAAGMVMGIYRDLAVGVSEGSTEIWANRDLYCPKASVGAPPDILGPLGQNWGLPPMNPNQLFEAAYQPMVDLFRANMRSCGALRIDHVMALLRLWWVPPGESAAKGAYIYYPVNDLLGILALESHRNQCLLIGEDLGTVPEGIDVTLKENGVHSYKVFFFERSKADGGFISPAHYAEQAMSALTTHDMPTLKGFWHCDDLALGRELGLYPDEDVLKTLYADRHQAKQRILDSLHGHGVISGNISHDVNWVGMNTELNHGLQLHMSRGSCALFSTQLEDWLEMDKPVNVPGTSYEYPNWRRKLSTDLEDIFANEALKALAGKMSQARDEASR
>CP028418.1|AZU49689.1|3872100_3872277_+|hypothetical-protein
MRIPAVDSIYTILINFYGWYLNSGSMGHAKPRTFLHICLAGCVTEQALLLITAPPGDR
>CP028418.1|AZU49690.1|3872443_3873439_+|glyceraldehyde-3-phosphate-dehydrogenase
MTIKVGINGFGRIGRFVFRLAAERSDIEVVGINDLIDVDYMAYMLKYDSTHGRFKGTVEVKDGNLVVNGKTVRVTAERDPANLKWGEIGVDVVAEATGLFLTDETARKHIAAGAKKVVLTGPSKDATPMFVMGVNDATYAGQDIVSNASCTTNCLAPIAKVLNDTFGIESGLMTTVHATTATQKTVDGPSAKDWRGGRGAAQNIIPSSTGAAKAVGVVIPELKGLLTGMAFRVPTPDVSVVDLTVNLKKAATYAEICEAMKAASEGAMKGVLGYTEDEVVSTDFLGERQTSVFDAKAGIQLNDKFVKVVSWYDNEMGYSSKVLDLIAHISK
>CP028418.1|AZU49691.1|3873554_3874421_+|aldose-epimerase
MQPTRSLTAHCTLSHHPAGQPLLTVDNGYAKAQISLFGAHVLSYQRHDEPASIWLSDKAVLDGSKPIRGGIPLCWPWFGPAPARVGSGKPSHGFARTSLWTLDGVSDHGDGTLVHLSLRDNETTRQLWPHAFELELDVLVGKELALVLTTRNTGKAPLVYSGALHTYLQISSPESVSVSGLGEPYADKLTGQNGQQQGPLTLNGPLDRVYWQPAAHVSIQDGERETRVVSGNHDSVVVWTPWLEGARAMADMSDDGYRTMLCVEAAIASEAGVTVAPDEEHSFSTVII
>CP028418.1|AZU49692.1|3874491_3875565_-|quinolinate-synthetase
MSNALNNVPPVVEMDYPFPAKPLPLSAEQKTTLIADIKALLKERKAVLVAHYYTDPEIQALAEETGGFVGDSLEMARFGRDHAAQTLIVAGVRFMGETSKILSPHKRVLMPTLAAECSLDLGCPIEQFSAFCDAHPDHIVVVYANTSAAVKARADWVVTSSIALEIVEHLDSQGHKIIWGPDRHLGAYIEKKTGAEMLRWQGHCIVHDEFKARALRELKEQNPDAAVLVHPESPASVIDLADAVGSTSQLIKAAKELPQQKLIVATDRGIFYKMQQACPEKEMVEAPTGGDGATCRSCAHCPWMAMNGLVAIKEALTDGAERHEILVDEDLRVKALIPLDRMLNFAAELRLKTQGNA
>CP028418.1|AZU49693.1|3875705_3876884_+|chemotaxis-protein
MKQRSLKTKLLLLTMGLFLASGLAMTLMQSSSLNTLRSNIVSQTRQALEQEVSRTLQFQAERYAVQIADLLQQSYQVPLGMAAQLEGSMAQPDRLLSRPQVETLLHSRLQQAGGISSIYAQFEPDGYDGQDASWQAGASHSVVGKGSLEIYFTRDQGGQISQQPVDAATSAAKYDTSVNEFGIRNSEWYLCGRDTLRPCLMEPYLYEISPGNKMLMTSLTVPVLKAGKFAGITGVDMNLPIFQQLAENLGKSLYNNQAEVTLVSKMGLIVGSNRHADKLGRPLTEAGLTAPTGQEQDTETDFILQQPVRIDAADTQWWLMLKVPKALALSQANIISNQLGDLLQATQQQQLIAIVVITLLALALLIWFIQTITAPSPSSVAMYPTYPATRGT

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Crispr_ID: CP028418_10

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP028418_10

4059898-4060001

Orphan

Consensus_repeat	Method
CTCTCCGTCACGGGCCTCGTCTATCGCACAGGA	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP028418_10

>merge|CP028418|10|4059898-4060001|CRISPRCasFinder
CTCTCCGTCACGGGCCTCGTCTATCGCACAGGACATCCATCATGACTCTGTTGGCCAGTCTGCACTTCTCCCTCTCCGTCACGGGCCCCGTCTATCGCACAGGA

>CP028418|10|10|4059898-4060001|CRISPRCasFinder
CTCTCCGTCACGGGCCTCGTCTATCGCACAGGA	CATCCATCATGACTCTGTTGGCCAGTCTGCACTTCTCC
CTCTCCGTCACGGGCCCCGTCTATCGCACAGGA

Protein	Signature genes	Signature genes Name	Protein_function
CP028418.1\|AZU49879.1\|4050674_4050980_+\|spermidine/putrescine-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224098
CP028418.1\|AZU49891.1\|4062651_4063638_-\|membrane-protein	unknown	unknown	gnl\|CDD\|223604
CP028418.1\|AZU49895.1\|4065222_4067328_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|377577
CP028418.1\|AZU49894.1\|4064903_4065134_-\|methylglyoxal-synthase	unknown	unknown	gnl\|CDD\|179969
CP028418.1\|AZU49893.1\|4064676_4064952_-\|methylglyoxal-synthase	unknown	unknown	gnl\|CDD\|179969
CP028418.1\|AZU49897.1\|4067530_4068010_-\|bacterioferritin	unknown	unknown	gnl\|CDD\|153099
CP028418.1\|AZU49881.1\|4052596_4052929_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU49882.1\|4053264_4054137_-\|membrane-protein	unknown	unknown	gnl\|CDD\|182525
CP028418.1\|AZU49884.1\|4054819_4055425_-\|maltose-O-acetyltransferase	unknown	unknown	gnl\|CDD\|100047
CP028418.1\|AZU49896.1\|4067339_4067456_-\|hypothetical-protein	unknown	unknown	unknown
CP028418.1\|AZU49890.1\|4061502_4062561_+\|L-asparaginase	unknown	unknown	gnl\|CDD\|182958
CP028418.1\|AZU49878.1\|4050198_4050717_+\|spermidine/putrescine-ABC-transporter-permease	unknown	unknown	gnl\|CDD\|224098
CP028418.1\|AZU49885.1\|4055428_4057090_-\|trehalose-6-phosphate-hydrolase	unknown	unknown	gnl\|CDD\|182849
CP028418.1\|AZU49892.1\|4064028_4064616_+\|hypothetical-protein	unknown	unknown	gnl\|CDD\|379492
CP028418.1\|AZU49887.1\|4058780_4059740_-\|trehalose-repressor	unknown	unknown	gnl\|CDD\|181905
CP028418.1\|AZU49880.1\|4051009_4052440_+\|gamma-aminobutyraldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237391
CP028418.1\|AZU49888.1\|4060009_4060960_+\|transporter	unknown	unknown	gnl\|CDD\|223751
CP028418.1\|AZU49883.1\|4054242_4054701_+\|AsnC-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224439
CP028418.1\|AZU49886.1\|4057158_4058589_-\|PTS-system-trehalose(maltose)-specific-transporter-subunits-IIBC	unknown	unknown	gnl\|CDD\|182896
CP028418.1\|AZU49889.1\|4061175_4061370_+\|mercuric-reductase	unknown	unknown	gnl\|CDD\|238219

Protein	Function_ID	Function_description	E-value
CP028418.1\|AZU49879.1\|4050674_4050980_+\|spermidine/putrescine-ABC-transporter-permease	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	1.10553e-24
CP028418.1\|AZU49891.1\|4062651_4063638_-\|membrane-protein	gnl\|CDD\|223604	COG0530, ECM27, Ca2+/Na+ antiporter [Inorganic ion transport and metabolism].	2.22503e-27
CP028418.1\|AZU49895.1\|4065222_4067328_-\|hypothetical-protein	gnl\|CDD\|377577	pfam05960, DUF885, Bacterial protein of unknown function (DUF885). This family consists of several hypothetical bacterial proteins several of which are putative membrane proteins.	6.511e-106
CP028418.1\|AZU49894.1\|4064903_4065134_-\|methylglyoxal-synthase	gnl\|CDD\|179969	PRK05234, mgsA, methylglyoxal synthase; Validated.	2.20028e-27
CP028418.1\|AZU49893.1\|4064676_4064952_-\|methylglyoxal-synthase	gnl\|CDD\|179969	PRK05234, mgsA, methylglyoxal synthase; Validated.	1.10021e-54
CP028418.1\|AZU49897.1\|4067530_4068010_-\|bacterioferritin	gnl\|CDD\|153099	cd00907, Bacterioferritin, Bacterioferritin, ferritin-like diiron-binding domain. Bacterioferritins, also known as cytochrome b1, are members of a broad superfamily of ferritin-like diiron-carboxylate proteins. Similar to ferritin in architecture, Bfr forms an oligomer of 24 subunits that assembles to form a hollow sphere with 432 symmetry. Up to 12 heme cofactor groups (iron protoporphyrin IX or coproporphyrin III) are bound between dimer pairs. The role of the heme is unknown, although it may be involved in mediating iron-core reduction and iron release. Each subunit is composed of a four-helix bundle which carries a diiron ferroxidase center; it is here that initial oxidation of ferrous iron by molecular oxygen occurs, facilitating the detoxification of iron, protection against dioxygen and radical products, and storage of ferric-hydroxyphosphate at the core. Some bacterioferritins are composed of two subunit types, one conferring heme-binding ability (alpha) and the other (beta) bestowing ferroxidase activity.	1.84902e-87
CP028418.1\|AZU49882.1\|4053264_4054137_-\|membrane-protein	gnl\|CDD\|182525	PRK10532, PRK10532, threonine and homoserine efflux system; Provisional.	2.80595e-81
CP028418.1\|AZU49884.1\|4054819_4055425_-\|maltose-O-acetyltransferase	gnl\|CDD\|100047	cd03357, LbH_MAT_GAT, Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6 position of the nonreducing end glucosyl moiety. GAT specifically acetylates galactopyranosides. Furthermore, MAT shows higher affinity toward artificial substrates containing an alkyl or hydrophobic chain as well as a glucosyl unit. Active MAT and GAT are homotrimers, with each subunit consisting of an N-terminal alpha-helical region and a C-terminal left-handed parallel alpha-helix (LbH) subdomain with 6 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X).	8.28603e-101
CP028418.1\|AZU49890.1\|4061502_4062561_+\|L-asparaginase	gnl\|CDD\|182958	PRK11096, ansB, L-asparaginase II; Provisional.	0
CP028418.1\|AZU49878.1\|4050198_4050717_+\|spermidine/putrescine-ABC-transporter-permease	gnl\|CDD\|224098	COG1177, PotC, ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism].	1.71606e-26
CP028418.1\|AZU49885.1\|4055428_4057090_-\|trehalose-6-phosphate-hydrolase	gnl\|CDD\|182849	PRK10933, PRK10933, trehalose-6-phosphate hydrolase; Provisional.	0
CP028418.1\|AZU49892.1\|4064028_4064616_+\|hypothetical-protein	gnl\|CDD\|379492	pfam14163, SieB, Super-infection exclusion protein B. This family includes superinfection exclusion proteins. These proteins prevent the growth of superinfecting phage which are insensitive to repression. It aborts lytic development of superinfecting phage.	3.05652e-44
CP028418.1\|AZU49887.1\|4058780_4059740_-\|trehalose-repressor	gnl\|CDD\|181905	PRK09492, treR, HTH-type transcriptional regulator TreR.	0
CP028418.1\|AZU49880.1\|4051009_4052440_+\|gamma-aminobutyraldehyde-dehydrogenase	gnl\|CDD\|237391	PRK13473, PRK13473, aminobutyraldehyde dehydrogenase.	0
CP028418.1\|AZU49888.1\|4060009_4060960_+\|transporter	gnl\|CDD\|223751	COG0679, COG0679, Predicted permeases [General function prediction only].	1.80204e-47
CP028418.1\|AZU49883.1\|4054242_4054701_+\|AsnC-family-transcriptional-regulator	gnl\|CDD\|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	3.4477e-37
CP028418.1\|AZU49886.1\|4057158_4058589_-\|PTS-system-trehalose(maltose)-specific-transporter-subunits-IIBC	gnl\|CDD\|182896	PRK11007, PRK11007, PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional.	0
CP028418.1\|AZU49889.1\|4061175_4061370_+\|mercuric-reductase	gnl\|CDD\|238219	cd00371, HMA, Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.	4.0841e-13

>CP028418.1|AZU49887.1|4058780_4059740_-|trehalose-repressor
MSHFMDKKLTILDIARLSGVGKSTVSRVLNQDPKVKRATRDRVEQIIAEHGFVPSKSARAMRSQSQQVVGIIVSRLDSSSENQAVRGMLETLYQRGYDAVLMESKFSPAKVQEHLAVLERRGVDGIILFAFNDLDYAAMAPLREKLVLVARDHPGFSSVCFDDAGAVHTMLDLLVARGIRDIAYLGVDTSDLTTGQRRLDAYLDYCAEQGLAARSALGDLSLQSGYRLAGELLTPTTGALVCASDTLAIGAAKYLQEQGRSEVLVTGLGNNPMLSFLFPNALSLDLGYKGAGEQAARQLLGQIEQDLPPLATIAPSHPL
>CP028418.1|AZU49886.1|4057158_4058589_-|PTS-system-trehalose(maltose)-specific-transporter-subunits-IIBC
MSKINAQHLATLIDKIGGKENIATVSHCLTRLRFVLNDPAKADSKAIETIPAVKGSFTQGGQFQVVIGNEVEQWYKALTEEIGVSGGSKEAAKQAARQNMNPLERGISHLAEIFVPLLPAIITGGLILGFRNVIGDIKMFDDGTHSLTEISQFWAQVHAFLWLLGEAIFHFLPVGVCWSAVKKMGGSEILGIVLGITLVSPQLMNAYGIGQQTPEVWDFGLFVIQKVGYQAQVIPALLAGVFLAWVETNLKRIIPAYLYLVIVPFISLLLAVIVAHAFIGPFGRWLGDGVGFAAKAAMTGSFAPIGAALFGFLYAPLVITGIHHTTNAVDLQLMQSMGGTPIWPLIALSNIAQASAVVGIILISRKENEREISVPAAISAYLGVTEPAMYGINLKYKFPMLCAMVGSSLAALICGFAGVMANGIGVGGLPGILSIQPQYWAIYSLAMLVAIVVPVVLTLLVYKRQQAAGKLAQASA
>CP028418.1|AZU49885.1|4055428_4057090_-|trehalose-6-phosphate-hydrolase
MSQTPWWQSAVIYQIYPKSFQDSAARGTGDLKGIMARLDYLKTLGVDALWLTPVYVSPQVDNGYDIADYLAIDPAYGTMADFEALLAAAHARDIRIVMDIVVNHTSTEHAWFKSALGDKNSPYRDYYIWRDPVDGGVPNNWQSKFGGSAWELDPATGQYYLHLFAREQADLNWENPAVRAEVKDIIHFWAKKGVDGFRLDVINLISKDQAFPNDEIGDGRRFYTDGPRIHEFLQDVSRDVFAPVGAMTVGEMSSTSLEHCQRYGALDGSELSMVFNFHHLKVDYPNGDKWTKAPFDFLELKRIFNHWQSGMHGKGWSALFWCNHDQPRIVSRFGDEGEHRVVAAKMLASTLHGLQGTPYIYQGEEIGMTNPGYQRIDDYQDVESRNIFAIKQAEGMSEAEILTILGAKSRDNSRTPMQWSAAANAGFTSGTPWLKPAANYPVINAEAALADQHSVFWHYRDLIRLRKAHPIFTQGDYQELLAGHPQIWAYARRANGQTLLVVSNFYGEPATFALPDELATGKGRLLLGNYPDSPARPQSCMLRPYESLIWLVE
>CP028418.1|AZU49884.1|4054819_4055425_-|maltose-O-acetyltransferase
MSEVMTKTAVRGVEWQKMVAGAPYDAGDPELKAARERCRRLYHTFNTSWQEKPERDALLHELLGGRGKACAINPPFFCDYGVNIFVGENFYANVGCTILDVCEVHIGDNVLLAPGVQIYTAAHPVAVAPRIKGVEFGKPVRIGHNVWIGGSTVICPGVTIGDNSVIGAGSVVTKDVPAGVVAAGNPCKVLRPMTAEELAAV
>CP028418.1|AZU49883.1|4054242_4054701_+|AsnC-family-transcriptional-regulator
MTDKFDLLILAELQQDARLPIPELAHRVGLSAPACYRRVRALREAELIEREVALVAPATMGWPITMLVLVTLERDHGRIVDEMIASLQGEPEVMDLWYVTGEQDFVLQVAARDMQSYDLFTRRVLHAREQVRSFKTLVVMKQHKRCGALLPA
>CP028418.1|AZU49882.1|4053264_4054137_-|membrane-protein
MPPNTTAFSSLLAVILAMLSITLGASLAKSLFPLIGAAGTTLFRLGCAALLLSLVFRIWRMPLDRRTLLGAIPYGLSLGAMNLLFYLAIERIPLGVALAIEFIGPLTVALLGSRHRADFLWLALAIVGLLLLLPLRAAEQTLDPLGAALALGAGVFWGLYMLTGKRAGALLGAQAQAPALGMWVGALLVLPFGLGGASEATFTLPVVLTIVGVGLLSSAIPYSLEMFALRRLPLKSYGILTSGEPAMGALMGLLLLGEQLPPAQWLGIAAIIVASMGTTWQGGRRRTEPA
>CP028418.1|AZU49881.1|4052596_4052929_-|hypothetical-protein
MNMKNVIKMLAVAGLMTAGFAQASVPADFNAAPGVLFVNWHATAAVEGKANPMLEVRDESGDVVASVHANLMGTQQVQIPSRTQGNLTVSLGDQSSDYRIPFGIGSGKQR
>CP028418.1|AZU49880.1|4051009_4052440_+|gamma-aminobutyraldehyde-dehydrogenase
MKLSTQLLIDGQFVTGDGQAEPILNPATGELLASVPEASFEQVNRAVNGAQRAFAQWSRTTPASRSALLLRLADAIERHAEEFAALESLNCGKPYLAVLNDELPAVVDCFRFFAGAARCLQGPLAGEYIEGHTSMIRRDPIGVVGSIAPWNYPLMMAAWKMAPVLAAGNTVVLKPSEQTPLTALRLAELASELFPRGVINIVCGRGESVGAPLVEHPLVRMVSLTGDIATGQKILQSAARTMKRTHLELGGKAPVIIFDDADLEAVVAGIRTFGFYNAGQDCTAACRIYAQGKIYDKFVAAMTEAVASIKVGGPREEGVEMGPLISDRQRNRVASFVERAQSSGHVEVTAGGKIRPGNGFFFEPTLIAHARQEDEIVRREVFGPVVSVTRFSDAEQVVQWANDSDYGLASSVWTKDLSLASKVASHLQYGCTWINTHFMLTSEMPHGGMKMSGYGKDLSLYALEDYTVPRHIMLKL
>CP028418.1|AZU49879.1|4050674_4050980_+|spermidine/putrescine-ABC-transporter-permease
MDLGADGFQTLRYVILPNLATALLAGGMLAFALSFDEVIVTTFTAGQQTTLPIWMYQELIRPRDRPVTNVVALIIVVFTTIPILLAYYLTRDGQDVAGSGK
>CP028418.1|AZU49878.1|4050198_4050717_+|spermidine/putrescine-ABC-transporter-permease
MLKYAAIGGLLFLHFPILFIFLYAFTSESKSYQFPPPGLTFKWFEVTLNRPDVWRAIQLSLEVAGLATLTAMVLGTLAAGAIARSRFFGQEVVSLLLVLPIALPGIVTGIALRSAYGVMEIPSASGPSSSVTPPSVWWWSTTMPWRAFAAPTSHSSKRRWISGPTASRPCAT
>CP028418.1|AZU49888.1|4060009_4060960_+|transporter
MTLLASLHFSLSITGPICVVLLLGIWLKQLGLLPDSFVESASRLVFQVTLPALLFLSMVRTDFSTMPSPWLILYGLLGTLTGFLVLELLAARFIPERRQRGIFVQGSFRGNMGIMGLAYVQNAYGAEGIGAAALLVGSVTVLYNVLAVITLTRSLGGSKGIKPILKGIAKNPLIIAILSALPFGLLGIELPQLVITTGNYFANMTLPLALLCTGASLNLKALRGGALLTGWATVNRLFCIPVLLVMGAWALGFNPQALGILFLISSTPTAAASYVMTRAMGGDSVLAANIIATTTLGSLVSTSLGAALMNYLGLMG
>CP028418.1|AZU49889.1|4061175_4061370_+|mercuric-reductase
MTIELTVSGMSCGGCAASLQKALLAQPAVSSASVDFASSKAVIESELSKAELIALIEAKGFSAS
>CP028418.1|AZU49890.1|4061502_4062561_+|L-asparaginase
MTLPIRKTLLAAVIGLTLSPMAMALPNVHILATGGTIAGAGQSATQSNYEAGKVAIETLIAAVPEMKNVADVQGEQVVKIGSQDMNDEVWLKLAKRVNELLAKDDVDGIVITHGTDTMEETAYFLNLTVKSDKPVVLVGAMRPSTAMSADGPMNLYNAVVTASDPASKGRGVMVAMNDTVLDARDVTKTNTTGVQTFASPNFGPLGYIHNGKIDYQRSPARLHTSKTPFDVSKLDKLPQVGIVYSYANATDLPAKAMVDAKFDGIVSAGVGNGNLYHTLFDTLAKASKDGIRVVRSARVPTGSTTLDAEIDDAKYGFVAAETLNPQKARILLMLSLTQSKDPAQIQRWFQQF
>CP028418.1|AZU49891.1|4062651_4063638_-|membrane-protein
MLITLLLFLLSAVTIYLACEYFVNGIEWTGHHFKFSQSATGSLLAALGTALPECIVTLTALLMGNAPAQQQIGIGAALGGPLVLSTIGNAAVGVTLLLCMSREHRAIDGAVQREIGRDQAWFVGIFLVAVALGMVAFTGKTWLAPLFVLVYLVYVRRELKQTDSHEVELPEPLKLDPGAEIPALGKVLLQTLVALVVVALAAQLFVHQLESMGELFGLSPVLAALLLSPVATEMPELMNVLIWVRQGKHRLALANISGAMMIQGTIPKAFCLLFTPWLLDSTMMVSSLVTLLAVVLLWWGFSRERMTAGRLAWVGLIYLGFCGWLMAN
>CP028418.1|AZU49892.1|4064028_4064616_+|hypothetical-protein
MKRWIQHFYQLNRLNWLMVWLLLCCSIILLFPAGLMKGAVSQWAATHAAWLGVGMLIAISYFCSQGFLIAWEWACDEWQSRRQQDQLAQMISFLDFNEKAVLREFVLQRKSVINLPITEPAVKNLMDAGVLTYAYGKPVREKEDENQIRALMIALPARPLLTYKVLGLSRGKMSDEQVEQIMNARPKFAQKSFQR
>CP028418.1|AZU49893.1|4064676_4064952_-|methylglyoxal-synthase
MSLLRPHGGDQQLGALIAEGKIDVLIFFWDPLNAVPHDPDVKALLRLAAVWNIPVATNEATADFIMDSPHMRQAFSVQIPDYAGYLKARTQ
>CP028418.1|AZU49894.1|4064903_4065134_-|methylglyoxal-synthase
MEQIAREMAAHKRVALVAHDNMKTPLLNWVMRRKEELKLHHLYATGTTGTMLGKQAQLPITCLFSGPMGATSSSAP
>CP028418.1|AZU49895.1|4065222_4067328_-|hypothetical-protein
MHFLPNKLALACAIALSLAACNDNSSNAPADPAATKASLMQTMDEALREGQALDPYGFAIDAASIAKRKALDSSLLKRLDALDSSVLSERDRLFYDMIRWDLQINLAGYDLPQSQIPIHHFRNRVVDLADEVGAAPASGRAARTVERGFDYFEQSSAERVAPGDAAWRRDLDRPAAAPVPASKARAATVPLAWYQEHLTWLKAYDGYLAEVKHQFELGSAQGNTLPDELVDRLLAQLNSKLDGEAVAGAYLGWQQLPGEADEALRSEYKGVLDSINGRYLALRDYLDYQHGGAYAVRLGSGECDDGFCGMTNGRDWYRWLLKKHTTTDMTPEQVHALGLSEVERIFGAMVKVCHTIGKCDSDDVSQSKQSGQIYAFFRYLNEPAFFYQNPLAVWSAGLNPDNAAGATLSGPQQQALAEHERALQEYNAFKSKAALVLPDFFDAERTIPKLDYEVVPVSYADAPYGGVAWYQDGNPQTGRKGQFFLNTYYPYGLQSWNISTLLAHEAAPGHHFQITIAQELAAKDPDFPQYVANASYTAYAEGWALYTEYLADHDMGLYQGRGLYDPAVGDVKVEGSSAFNNQLQYFGRLNEEMLRAMRLVVDTGIHWYGWSHDQAVNYMKENSALGAGDISSEVPRYMAYTGQATSYKAGQLALIRMRESAEQALGGRFDLKAFHHHVLEYGMLPISVLEQKNKQWIEQSK
>CP028418.1|AZU49896.1|4067339_4067456_-|hypothetical-protein
MKLITMKSKLIFVNQVAKKYAGEMHYWNPLLGTNNNNG
>CP028418.1|AZU49897.1|4067530_4068010_-|bacterioferritin
MKGDPKIIAHLNKVLANELIAINQYFLHARIYDDWGLKALGHKEYHESIDEMKHADELVKRVLFLEGLPNLQDLGKLRIGETVEEMLRCDLSLEMDAIPDLKVAIAYAESVQDYISRDLFQEILEDEEEHVDWLETQLDLIDRIGLENYQQSQLHHGGS

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	CP045556	Citrobacter sp. S39 plasmid pS39-1, complete sequence	22876-22906	6	0.806
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	NZ_MG387191	Citrobacter freundii strain 2262 plasmid pTEM-2262, complete sequence	38656-38686	6	0.806
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	NZ_CP049252	Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed5, complete sequence	1281-1311	6	0.806
CP028418_3	3.4\|1931145\|31\|CP028418\|CRISPRCasFinder	1931145-1931175	31	NC_007960	Nitrobacter hamburgensis X14 plasmid 2, complete sequence	20140-20170	6	0.806
CP028418_3	3.5\|1931202\|31\|CP028418\|CRISPRCasFinder	1931202-1931232	31	NZ_CP015269	Mycobacterium chimaera strain ZUERICH-2 plasmid unnamed 2, complete sequence	126456-126486	6	0.806
CP028418_3	3.5\|1931202\|31\|CP028418\|CRISPRCasFinder	1931202-1931232	31	NZ_CP029356	Azospirillum sp. CFH 70021 plasmid unnamed1	613160-613190	7	0.774
CP028418_3	3.5\|1931202\|31\|CP028418\|CRISPRCasFinder	1931202-1931232	31	NZ_CP015319	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123a	41242-41272	7	0.774
CP028418_3	3.5\|1931202\|31\|CP028418\|CRISPRCasFinder	1931202-1931232	31	NZ_CP015322	Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence	555170-555200	7	0.774
CP028418_3	3.7\|1931039\|36\|CP028418\|PILER-CR	1931039-1931074	36	NZ_CP021033	Rhizobium sp. NXC14 plasmid pRspNXC14c, complete sequence	289302-289337	7	0.806
CP028418_3	3.7\|1931039\|36\|CP028418\|PILER-CR	1931039-1931074	36	NZ_CP021025	Rhizobium sp. TAL182 plasmid pRetTAL182a, complete sequence	115817-115852	7	0.806
CP028418_3	3.7\|1931039\|36\|CP028418\|PILER-CR	1931039-1931074	36	NZ_CP013600	Rhizobium sp. N741 plasmid pRspN741e, complete sequence	221652-221687	7	0.806
CP028418_3	3.7\|1931039\|36\|CP028418\|PILER-CR	1931039-1931074	36	NZ_CP013504	Rhizobium esperanzae strain N561 plasmid pRspN561d, complete sequence	221652-221687	7	0.806
CP028418_3	3.7\|1931039\|36\|CP028418\|PILER-CR	1931039-1931074	36	NZ_CP013510	Rhizobium sp. N1341 plasmid pRspN1341e, complete sequence	220093-220128	7	0.806
CP028418_3	3.7\|1931039\|36\|CP028418\|PILER-CR	1931039-1931074	36	NZ_CP013521	Rhizobium sp. N113 plasmid pRspN113d, complete sequence	224340-224375	7	0.806
CP028418_3	3.7\|1931039\|36\|CP028418\|PILER-CR	1931039-1931074	36	NZ_CP013494	Rhizobium sp. N6212 plasmid pRspN6212d, complete sequence	218458-218493	7	0.806
CP028418_3	3.7\|1931039\|36\|CP028418\|PILER-CR	1931039-1931074	36	NZ_CP013512	Rhizobium sp. N1314 plasmid pRspN1314a, complete sequence	111766-111801	7	0.806
CP028418_3	3.7\|1931039\|36\|CP028418\|PILER-CR	1931039-1931074	36	NZ_CP013594	Rhizobium sp. N871 plasmid pRspN871d, complete sequence	221652-221687	7	0.806
CP028418_3	3.1\|1930962\|31\|CP028418\|CRISPRCasFinder	1930962-1930992	31	NZ_CP016452	Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence	1408973-1409003	8	0.742
CP028418_3	3.1\|1930962\|31\|CP028418\|CRISPRCasFinder	1930962-1930992	31	NZ_CP047266	Pseudomonas asturiensis strain CC1524 plasmid pCC1524, complete sequence	61579-61609	8	0.742
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	MN204498	Streptomyces phage Saftant, complete genome	9608-9638	8	0.742
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	AP018715	Enterococcus phage phiM1EF22 DNA, complete sequence	133283-133313	8	0.742
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	MN854830	Enterococcus phage PBEF129, complete genome	27315-27345	8	0.742
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	KJ801817	Enterococcus phage ECP3, complete genome	107178-107208	8	0.742
CP028418_3	3.5\|1931202\|31\|CP028418\|CRISPRCasFinder	1931202-1931232	31	NZ_CP045120	Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence	153877-153907	8	0.742
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	NZ_CP045373	Sulfitobacter sp. THAF37 plasmid pTHAF37_a, complete sequence	107535-107565	9	0.71
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	NZ_CP045373	Sulfitobacter sp. THAF37 plasmid pTHAF37_a, complete sequence	149051-149081	9	0.71
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	NZ_CP018081	Sulfitobacter sp. AM1-D1 plasmid unnamed5, complete sequence	298532-298562	9	0.71
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	NZ_CP045378	Sulfitobacter sp. THAF37 plasmid pTHAF37_f, complete sequence	31413-31443	9	0.71
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	NZ_CP018080	Sulfitobacter sp. AM1-D1 plasmid unnamed4, complete sequence	15639-15669	9	0.71
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	NZ_CP018080	Sulfitobacter sp. AM1-D1 plasmid unnamed4, complete sequence	46538-46568	9	0.71
CP028418_3	3.5\|1931202\|31\|CP028418\|CRISPRCasFinder	1931202-1931232	31	NC_027340	Erwinia phage phiEa2809, complete genome	19904-19934	9	0.71
CP028418_3	3.5\|1931202\|31\|CP028418\|CRISPRCasFinder	1931202-1931232	31	NC_048702	Erwinia phage vB_EamM-Bue1, complete genome	18570-18600	9	0.71
CP028418_3	3.3\|1931088\|31\|CP028418\|CRISPRCasFinder	1931088-1931118	31	NZ_CP025432	Paracoccus zhejiangensis strain J6 plasmid pPZ02, complete sequence	43018-43048	10	0.677

1. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to CP045556 (Citrobacter sp. S39 plasmid pS39-1, complete sequence) position: , mismatch: 6, identity: 0.806

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cgcgctgcgcaacggcaacgtgcaggcgatt	Protospacer
*. *  * ********** ************

2. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to NZ_MG387191 (Citrobacter freundii strain 2262 plasmid pTEM-2262, complete sequence) position: , mismatch: 6, identity: 0.806

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cgcgctgcgcaacggcaacgtgcaggcgatt	Protospacer
*. *  * ********** ************

3. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to NZ_CP049252 (Rhizobium rhizoryzae strain DSM 29514 plasmid unnamed5, complete sequence) position: , mismatch: 6, identity: 0.806

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cagctacggcaacggcaaggtgcaggtgttt	Protospacer
**.  * *******************.* **

4. spacer 3.4|1931145|31|CP028418|CRISPRCasFinder matches to NC_007960 (Nitrobacter hamburgensis X14 plasmid 2, complete sequence) position: , mismatch: 6, identity: 0.806

ccagc-ttggtcagggggatacccaggcgctg	CRISPR spacer
-aagcgatggtcaggaggagacccaggcgctc	Protospacer
  ***  ********.*** ***********

5. spacer 3.5|1931202|31|CP028418|CRISPRCasFinder matches to NZ_CP015269 (Mycobacterium chimaera strain ZUERICH-2 plasmid unnamed 2, complete sequence) position: , mismatch: 6, identity: 0.806

ccgggtcggtgatggcgatctctctgcggtg	CRISPR spacer
ccggatcggtgatgacgatctcttggccggg	Protospacer
****.*********.********. ** * *

6. spacer 3.5|1931202|31|CP028418|CRISPRCasFinder matches to NZ_CP029356 (Azospirillum sp. CFH 70021 plasmid unnamed1) position: , mismatch: 7, identity: 0.774

ccgggtcggtgatggcgatctctctgcggtg	CRISPR spacer
gcgggtcggtgacggcgaactctctgcccat	Protospacer
 ***********.***** ********

7. spacer 3.5|1931202|31|CP028418|CRISPRCasFinder matches to NZ_CP015319 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123a) position: , mismatch: 7, identity: 0.774

ccgggtcggtgatggcgatctctctgcggtg	CRISPR spacer
ctatggcggttatggcgatctctatgcggcg	Protospacer
*.. * **** ************ *****.*

8. spacer 3.5|1931202|31|CP028418|CRISPRCasFinder matches to NZ_CP015322 (Mesorhizobium amorphae CCNWGS0123 plasmid pM0123d, complete sequence) position: , mismatch: 7, identity: 0.774

ccgggtcggtgatggcgatctctctgcggtg	CRISPR spacer
ctatggcggttatggcgatctctatgcggcg	Protospacer
*.. * **** ************ *****.*

9. spacer 3.7|1931039|36|CP028418|PILER-CR matches to NZ_CP021033 (Rhizobium sp. NXC14 plasmid pRspNXC14c, complete sequence) position: , mismatch: 7, identity: 0.806

tcacgtcactcagggcgaggaggctgccggcacccg	CRISPR spacer
ttatgccatccagggcgaggaggctgtcggcaaccg	Protospacer
*.*.*.**..****************.***** ***

10. spacer 3.7|1931039|36|CP028418|PILER-CR matches to NZ_CP021025 (Rhizobium sp. TAL182 plasmid pRetTAL182a, complete sequence) position: , mismatch: 7, identity: 0.806

tcacgtcactcagggcgaggaggctgccggcacccg	CRISPR spacer
ttatgccatccagggcgaggaggctgtcggcaaccg	Protospacer
*.*.*.**..****************.***** ***

11. spacer 3.7|1931039|36|CP028418|PILER-CR matches to NZ_CP013600 (Rhizobium sp. N741 plasmid pRspN741e, complete sequence) position: , mismatch: 7, identity: 0.806

tcacgtcactcagggcgaggaggctgccggcacccg	CRISPR spacer
ttatgccatccagggcgaggaggctgtcggcaaccg	Protospacer
*.*.*.**..****************.***** ***

12. spacer 3.7|1931039|36|CP028418|PILER-CR matches to NZ_CP013504 (Rhizobium esperanzae strain N561 plasmid pRspN561d, complete sequence) position: , mismatch: 7, identity: 0.806

tcacgtcactcagggcgaggaggctgccggcacccg	CRISPR spacer
ttatgccatccagggcgaggaggctgtcggcaaccg	Protospacer
*.*.*.**..****************.***** ***

13. spacer 3.7|1931039|36|CP028418|PILER-CR matches to NZ_CP013510 (Rhizobium sp. N1341 plasmid pRspN1341e, complete sequence) position: , mismatch: 7, identity: 0.806

tcacgtcactcagggcgaggaggctgccggcacccg	CRISPR spacer
ttatgccatccagggcgaggaggctgtcggcaaccg	Protospacer
*.*.*.**..****************.***** ***

14. spacer 3.7|1931039|36|CP028418|PILER-CR matches to NZ_CP013521 (Rhizobium sp. N113 plasmid pRspN113d, complete sequence) position: , mismatch: 7, identity: 0.806

tcacgtcactcagggcgaggaggctgccggcacccg	CRISPR spacer
ttatgccatccagggcgaggaggctgtcggcaaccg	Protospacer
*.*.*.**..****************.***** ***

15. spacer 3.7|1931039|36|CP028418|PILER-CR matches to NZ_CP013494 (Rhizobium sp. N6212 plasmid pRspN6212d, complete sequence) position: , mismatch: 7, identity: 0.806

tcacgtcactcagggcgaggaggctgccggcacccg	CRISPR spacer
ttatgccatccagggcgaggaggctgtcggcaaccg	Protospacer
*.*.*.**..****************.***** ***

16. spacer 3.7|1931039|36|CP028418|PILER-CR matches to NZ_CP013512 (Rhizobium sp. N1314 plasmid pRspN1314a, complete sequence) position: , mismatch: 7, identity: 0.806

tcacgtcactcagggcgaggaggctgccggcacccg	CRISPR spacer
ttatgccatccagggcgaggaggctgtcggcaaccg	Protospacer
*.*.*.**..****************.***** ***

17. spacer 3.7|1931039|36|CP028418|PILER-CR matches to NZ_CP013594 (Rhizobium sp. N871 plasmid pRspN871d, complete sequence) position: , mismatch: 7, identity: 0.806

tcacgtcactcagggcgaggaggctgccggcacccg	CRISPR spacer
ttatgccatccagggcgaggaggctgtcggcaaccg	Protospacer
*.*.*.**..****************.***** ***

18. spacer 3.1|1930962|31|CP028418|CRISPRCasFinder matches to NZ_CP016452 (Sinorhizobium sp. RAC02 plasmid pBSY16_1, complete sequence) position: , mismatch: 8, identity: 0.742

caagctgggtgcgggtcaactgaccgccggc	CRISPR spacer
gatcatgggtgcgggtcaacggatcgccgcg	Protospacer
 *   *************** **.*****

19. spacer 3.1|1930962|31|CP028418|CRISPRCasFinder matches to NZ_CP047266 (Pseudomonas asturiensis strain CC1524 plasmid pCC1524, complete sequence) position: , mismatch: 8, identity: 0.742

caagctgggtgcgggtcaactgaccgccggc	CRISPR spacer
ccagctgggtgcgggtcatctggcccgtgcg	Protospacer
* **************** ***.**  .*

20. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to MN204498 (Streptomyces phage Saftant, complete genome) position: , mismatch: 8, identity: 0.742

caagaagggcaacggcaaggtgca-----ggcgatt	CRISPR spacer
caagaagcgcaagggcaaggtgcacctctga-----	Protospacer
******* **** ***********     *.

21. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to AP018715 (Enterococcus phage phiM1EF22 DNA, complete sequence) position: , mismatch: 8, identity: 0.742

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cagttagggcaaagacaaggtgcaggcgcag	Protospacer
**.  ******* *.*************

22. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to MN854830 (Enterococcus phage PBEF129, complete genome) position: , mismatch: 8, identity: 0.742

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cagttagggcaaagacaaggtgcaggcgcag	Protospacer
**.  ******* *.*************

23. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to KJ801817 (Enterococcus phage ECP3, complete genome) position: , mismatch: 8, identity: 0.742

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cagttagggcaaagacaaggtgcaggcgcag	Protospacer
**.  ******* *.*************

24. spacer 3.5|1931202|31|CP028418|CRISPRCasFinder matches to NZ_CP045120 (Rubrobacter sp. SCSIO 52909 plasmid unnamed1, complete sequence) position: , mismatch: 8, identity: 0.742

ccggg---tcggtgatggcgatctctctgcggtg	CRISPR spacer
---ggttctcggtgatggcgacctctatgcgtcc	Protospacer
   **   *************.**** **** .

25. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to NZ_CP045373 (Sulfitobacter sp. THAF37 plasmid pTHAF37_a, complete sequence) position: , mismatch: 9, identity: 0.71

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cggacggggcagcggcaaggtgcaggtgaag	Protospacer
*... .*****.**************.**

26. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to NZ_CP045373 (Sulfitobacter sp. THAF37 plasmid pTHAF37_a, complete sequence) position: , mismatch: 9, identity: 0.71

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cggacggggcagcggcaaggtgcaggtgaag	Protospacer
*... .*****.**************.**

27. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to NZ_CP018081 (Sulfitobacter sp. AM1-D1 plasmid unnamed5, complete sequence) position: , mismatch: 9, identity: 0.71

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cggacggggcagcggcaaggtgcaggtgaag	Protospacer
*... .*****.**************.**

28. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to NZ_CP045378 (Sulfitobacter sp. THAF37 plasmid pTHAF37_f, complete sequence) position: , mismatch: 9, identity: 0.71

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cggacggggcagcggcaaggtgcaggtgaag	Protospacer
*... .*****.**************.**

29. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to NZ_CP018080 (Sulfitobacter sp. AM1-D1 plasmid unnamed4, complete sequence) position: , mismatch: 9, identity: 0.71

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cggacggggcagcggcaaggtgcaggtgaag	Protospacer
*... .*****.**************.**

30. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to NZ_CP018080 (Sulfitobacter sp. AM1-D1 plasmid unnamed4, complete sequence) position: , mismatch: 9, identity: 0.71

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
cggacggggcagcggcaaggtgcaggtgaag	Protospacer
*... .*****.**************.**

31. spacer 3.5|1931202|31|CP028418|CRISPRCasFinder matches to NC_027340 (Erwinia phage phiEa2809, complete genome) position: , mismatch: 9, identity: 0.71

ccgggtcggtgatggcgatctctctgcggtg	CRISPR spacer
ggcggtcggtgattgcgatctctgtggtcag	Protospacer
   ********** ********* **    *

32. spacer 3.5|1931202|31|CP028418|CRISPRCasFinder matches to NC_048702 (Erwinia phage vB_EamM-Bue1, complete genome) position: , mismatch: 9, identity: 0.71

ccgggtcggtgatggcgatctctctgcggtg	CRISPR spacer
ggcggtcggtgattgcgatctctgtggtcag	Protospacer
   ********** ********* **    *

33. spacer 3.3|1931088|31|CP028418|CRISPRCasFinder matches to NZ_CP025432 (Paracoccus zhejiangensis strain J6 plasmid pPZ02, complete sequence) position: , mismatch: 10, identity: 0.677

caagaagggcaacggcaaggtgcaggcgatt	CRISPR spacer
tttcgcgggcgacggcaaggtgaaggcgacc	Protospacer
.   . ****.*********** ******..

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1304259 : 1314192

uncultured_Mediterranean_phage(25.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZU47152.1\|1304259_1305006_+	stationary phase survival protein SurE	A0A1B1ITZ2	uncultured_Mediterranean_phage	5.5e-70	54.1
AZU47153.1\|1305010_1305628_+	protein-L-isoaspartate O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	4.0e-34	46.4
AZU47154.1\|1305757_1306204_+	hypothetical protein	NA	NA	NA	NA
AZU47155.1\|1306250_1306514_+	lipoprotein NlpD	NA	NA	NA	NA
AZU47156.1\|1306684_1307254_+	peptidoglycan-binding protein	I2E8W3	Clostridium_phage	1.7e-10	34.7
AZU47157.1\|1307301_1308285_+	RNA polymerase sigma factor	F4YCU2	Synechococcus_phage	1.7e-34	34.1
AZU47158.1\|1308369_1309383_-	UGMP family protein	A0A0R6PI74	Moraxella_phage	9.1e-108	58.3
AZU47159.1\|1309562_1309778_+	30S ribosomal protein S21	NA	NA	NA	NA
AZU47160.1\|1309793_1310237_+	GatB/YqeY domain-containing protein	A0A292GL36	Xanthomonas_phage	1.7e-26	48.6
AZU47161.1\|1310325_1312113_+	DNA primase	A0A0K1LMQ9	Caulobacter_phage	5.2e-74	41.1
AZU47162.1\|1312335_1314192_+	RNA polymerase sigma factor RpoD	A0A2I7SAT0	Vibrio_phage	1.1e-34	32.6

DBSCAN-SWA_2

1578306 : 1583430

Escherichia_phage(83.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZU47434.1\|1578306_1578798_-	hypothetical protein	Q76TT0	Molluscum_contagiosum_virus	1.4e-05	32.5
AZU47435.1\|1578833_1579607_-	hydroxypyruvate isomerase	NA	NA	NA	NA
AZU47436.1\|1579603_1580236_-	aldolase	A0A077SK32	Escherichia_phage	2.4e-74	66.5
AZU47437.1\|1580228_1581479_-	membrane protein	A0A077SLJ7	Escherichia_phage	2.8e-127	61.8
AZU47438.1\|1581475_1582384_-	3-hydroxyisobutyrate dehydrogenase	A0A077SLF7	Escherichia_phage	1.1e-107	72.0
AZU47439.1\|1582639_1582807_+	DeoR family transcriptional regulator	A0A077SK06	Escherichia_phage	2.3e-13	70.9
AZU47440.1\|1582803_1583430_+	DeoR family transcriptional regulator	A0A077SK06	Escherichia_phage	5.3e-42	47.6

DBSCAN-SWA_3

2031221 : 2092290

Aeromonas_phage(83.58%)

bacteriocin,terminase,integrase,portal

attL 2023261:2023277|attR 2046533:2046549

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
2023261:2023277	attL	NA	NA	NA	NA
AZU47892.1\|2031221_2034755_-	DEAD/DEAH box helicase	A0A2I7QZ21	Vibrio_phage	1.2e-05	22.0
AZU47893.1\|2034757_2035696_-	restriction endonuclease	NA	NA	NA	NA
AZU47894.1\|2035971_2037141_-\|integrase	integrase	I6PDJ1	Cronobacter_phage	3.5e-127	59.2
AZU47895.1\|2037107_2037305_-	excisionase	I6PBM8	Cronobacter_phage	7.3e-14	55.7
AZU47896.1\|2037297_2037735_-	hypothetical protein	A0A1I9KG69	Aeromonas_phage	8.8e-44	73.3
AZU47897.1\|2037791_2037956_-	hypothetical protein	NA	NA	NA	NA
AZU47898.1\|2037972_2038194_-	hypothetical protein	NA	NA	NA	NA
AZU47899.1\|2038303_2038492_-	hypothetical protein	NA	NA	NA	NA
AZU47900.1\|2038580_2038886_-	hypothetical protein	A0A1I9KFD3	Aeromonas_phage	1.3e-41	91.3
AZU47901.1\|2038929_2039148_-	hypothetical protein	A0A1I9KF77	Aeromonas_phage	1.0e-32	93.1
AZU47902.1\|2039111_2040263_-	hypothetical protein	A0A1I9KFE6	Aeromonas_phage	6.8e-19	41.0
AZU47903.1\|2040259_2040871_-	hypothetical protein	A0A1I9KF82	Aeromonas_phage	1.0e-69	74.0
AZU47904.1\|2040867_2041125_-	hypothetical protein	R9VX58	Serratia_phage	3.0e-15	58.6
AZU47905.1\|2041121_2041670_-	hypothetical protein	NA	NA	NA	NA
AZU47906.1\|2041666_2042578_-	recombinase	A0A1I9KF67	Aeromonas_phage	1.4e-83	51.7
AZU47907.1\|2042601_2042781_-	hypothetical protein	A0A1I9KFZ1	Aeromonas_phage	6.6e-22	83.1
AZU47908.1\|2042839_2043418_-	hypothetical protein	A0A1I9KF87	Aeromonas_phage	4.5e-104	93.8
AZU47909.1\|2043410_2043866_-	hypothetical protein	A0A1I9KF89	Aeromonas_phage	3.7e-61	75.5
AZU47910.1\|2043862_2044471_-	hypothetical protein	A0A076G7C3	Sinorhizobium_phage	4.5e-30	37.9
AZU47911.1\|2044467_2044950_-	hypothetical protein	A0A1I9KG78	Aeromonas_phage	7.0e-26	63.1
AZU47912.1\|2044999_2046142_-	hypothetical protein	A0A1I9KFA0	Aeromonas_phage	1.0e-83	82.1
AZU47913.1\|2046190_2047168_-	recombinase	A0A1I9KF88	Aeromonas_phage	2.8e-178	93.2
2046533:2046549	attR	NA	NA	NA	NA
AZU47914.1\|2047164_2048010_-	exodeoxyribonuclease VIII	A0A1I9KFF5	Aeromonas_phage	2.5e-159	94.3
AZU47915.1\|2048006_2048372_-	hypothetical protein	A0A1I9KFC9	Aeromonas_phage	2.5e-36	67.8
AZU47916.1\|2048374_2048566_-	hypothetical protein	A0A1I9KG01	Aeromonas_phage	1.5e-11	61.3
AZU47917.1\|2048640_2049327_-	hypothetical protein	A0A1C9IHV9	Salmonella_phage	6.5e-25	54.5
AZU47918.1\|2049650_2050463_-	Sel1 domain-containing protein	NA	NA	NA	NA
AZU47919.1\|2050853_2051105_-	hypothetical protein	A0A1I9KF98	Aeromonas_phage	2.2e-07	43.4
AZU47920.1\|2051531_2052173_-	DNA-binding protein	A0A0A7RTW0	Clostridium_phage	2.4e-05	43.4
AZU47921.1\|2052265_2052484_+	hypothetical protein	NA	NA	NA	NA
AZU47922.1\|2052529_2053231_+	DNA-binding protein	A0A1I9KFA9	Aeromonas_phage	2.9e-89	73.8
AZU47923.1\|2053377_2053659_+	hypothetical protein	A0A1I9KF96	Aeromonas_phage	3.8e-40	94.5
AZU47924.1\|2053662_2053881_+	hypothetical protein	A0A1I9KFG0	Aeromonas_phage	2.9e-27	91.7
AZU47925.1\|2053946_2054084_+	hypothetical protein	A0A1I9KFA1	Aeromonas_phage	9.5e-13	74.4
AZU47926.1\|2054080_2055694_+	DNA restriction methylase	A0A059VA49	Pseudomonas_phage	1.0e-161	55.0
AZU47927.1\|2055759_2056725_+	hypothetical protein	K7PLZ7	Enterobacterial_phage	5.0e-23	43.5
AZU47928.1\|2056774_2057191_+	hypothetical protein	NA	NA	NA	NA
AZU47929.1\|2057468_2057771_+	hypothetical protein	A0A1I9KFB1	Aeromonas_phage	2.0e-39	80.0
AZU47930.1\|2057847_2058468_+	hypothetical protein	A0A2I6PG18	Plesiomonas_phage	1.4e-39	52.5
AZU47931.1\|2058524_2058908_+	hypothetical protein	A0A1I9KFA6	Aeromonas_phage	6.1e-65	96.9
AZU47932.1\|2058967_2059564_+	adenylosuccinate synthase	A0A1I9KFG5	Aeromonas_phage	1.2e-104	91.4
AZU47933.1\|2059560_2059878_+	hypothetical protein	A0A1I9KFA7	Aeromonas_phage	2.7e-50	91.4
AZU47934.1\|2059874_2060297_+	hypothetical protein	A0A1I9KG18	Aeromonas_phage	2.6e-64	82.9
AZU47935.1\|2060293_2060992_+	hypothetical protein	A0A1I9KFB9	Aeromonas_phage	8.1e-108	85.8
AZU47936.1\|2061998_2062151_-	protein UmuC	NA	NA	NA	NA
AZU47937.1\|2062150_2062612_-	protein UmuC	F1C5A5	Cronobacter_phage	5.9e-38	53.6
AZU47938.1\|2063017_2063335_+	membrane protein	A0A1I9KFB8	Aeromonas_phage	1.4e-51	95.2
AZU47939.1\|2063334_2063814_+	hypothetical protein	A0A1I9KGA3	Aeromonas_phage	3.3e-84	94.2
AZU47940.1\|2063869_2064094_+	hypothetical protein	A0A1I9KFG6	Aeromonas_phage	1.7e-30	100.0
AZU47941.1\|2064095_2064326_+	hypothetical protein	A0A1I9KFC5	Aeromonas_phage	6.7e-27	81.6
AZU47942.1\|2064397_2064559_+	hypothetical protein	A0A1I9KFC1	Aeromonas_phage	2.9e-16	83.0
AZU47943.1\|2064982_2065429_+\|terminase	terminase	A0A1I9KFG9	Aeromonas_phage	3.1e-68	94.6
AZU47944.1\|2065702_2065822_+	hypothetical protein	NA	NA	NA	NA
AZU47945.1\|2065880_2066630_+	hypothetical protein	A0A1I9KFB6	Aeromonas_phage	9.4e-94	88.5
AZU47946.1\|2066838_2067048_+	hypothetical protein	A0A1I9KFB6	Aeromonas_phage	4.4e-17	78.0
AZU47947.1\|2067432_2067633_+\|terminase	terminase	A0A1I9KFB6	Aeromonas_phage	1.3e-10	94.1
AZU47948.1\|2067718_2068942_+\|portal	portal protein	A0A1I9KFF7	Aeromonas_phage	4.0e-211	96.2
AZU47949.1\|2068920_2069691_+\|portal	portal protein	A0A1I9KFF7	Aeromonas_phage	8.2e-85	85.9
AZU47950.1\|2069812_2070136_+	hypothetical protein	A0A1I9KG26	Aeromonas_phage	1.9e-27	94.3
AZU47951.1\|2070278_2071208_+	hypothetical protein	A0A1I9KFD1	Aeromonas_phage	8.6e-121	75.1
AZU47952.1\|2071280_2072498_+	virion structural protein	A0A1I9KFC6	Aeromonas_phage	1.4e-216	90.9
AZU47953.1\|2072561_2072951_+	hypothetical protein	A0A1I9KGB3	Aeromonas_phage	1.6e-57	89.9
AZU47954.1\|2073017_2073458_+	hypothetical protein	A0A1I9KFH0	Aeromonas_phage	8.3e-50	81.6
AZU47955.1\|2073460_2074042_+	hypothetical protein	A0A1I9KFD5	Aeromonas_phage	5.8e-91	84.5
AZU47956.1\|2074051_2074729_+	hypothetical protein	A0A1I9KFD0	Aeromonas_phage	7.9e-100	77.8
AZU47957.1\|2074741_2074867_+	hypothetical protein	A0A1I9KFH7	Aeromonas_phage	1.7e-13	90.0
AZU47958.1\|2074863_2076300_+	hypothetical protein	A0A1I9KFH7	Aeromonas_phage	1.8e-37	72.9
AZU47959.1\|2076463_2076787_+	hypothetical protein	A0A2R4ALX6	Aeromonas_phage	2.3e-33	73.8
AZU47960.1\|2076828_2077557_+	hypothetical protein	A0A1I9KFD2	Aeromonas_phage	9.5e-83	74.0
AZU47961.1\|2077642_2078485_+	hypothetical protein	A0A1I9KFD2	Aeromonas_phage	5.9e-137	81.8
AZU47962.1\|2078484_2082219_+	hypothetical protein	A0A1I9KGC4	Aeromonas_phage	3.1e-185	64.6
AZU47963.1\|2082398_2082584_+	hypothetical protein	A0A1I9KFI0	Aeromonas_phage	4.1e-27	91.7
AZU47964.1\|2082598_2083231_+	hypothetical protein	A0A1I9KFE8	Aeromonas_phage	7.4e-92	87.7
AZU47965.1\|2083241_2083622_+	hypothetical protein	A0A1I9KFD7	Aeromonas_phage	1.8e-48	83.1
AZU47966.1\|2083669_2083882_+\|bacteriocin	bacteriocin	NA	NA	NA	NA
AZU47967.1\|2083891_2085292_+	hypothetical protein	A0A1I9KFD9	Aeromonas_phage	2.1e-203	84.8
AZU47968.1\|2085725_2091734_+	hypothetical protein	A0A1I9KFG8	Aeromonas_phage	3.1e-30	34.0
AZU47969.1\|2092170_2092290_+	hypothetical protein	A0A1I9KG40	Aeromonas_phage	9.8e-06	66.7

DBSCAN-SWA_4

2606775 : 2616372

Enterobacteria_phage(22.22%)

integrase

attL 2608916:2608934|attR 2623477:2623495

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
AZU48466.1\|2606775_2607039_+	glutaredoxin glutaredoxin	K4F6R0	Cronobacter_phage	2.0e-14	49.4
AZU48467.1\|2607096_2607309_-	hypothetical protein	A0A0C5KKW3	Enterococcus_phage	5.1e-05	44.9
AZU48468.1\|2607688_2608903_+	aminotransferase AlaT	NA	NA	NA	NA
2608916:2608934	attL	NA	NA	NA	NA
AZU48469.1\|2609042_2609192_-\|integrase	integrase	Q83VS6	Escherichia_phage	7.2e-14	69.4
AZU48470.1\|2610095_2610260_-	repressor	Q1JS61	Enterobacteria_phage	9.0e-10	51.9
AZU48471.1\|2610502_2610832_+	regulatory protein	Q1JS60	Enterobacteria_phage	9.6e-27	64.0
AZU48472.1\|2610828_2611068_+	hypothetical protein	NA	NA	NA	NA
AZU48473.1\|2611067_2611268_+	hypothetical protein	NA	NA	NA	NA
AZU48474.1\|2611267_2611579_+	hypothetical protein	A5X9H0	Aeromonas_virus	1.6e-18	61.2
AZU48475.1\|2611659_2612214_+	hypothetical protein	A4PE29	Ralstonia_virus	5.6e-11	32.9
AZU48476.1\|2612227_2613193_+	hypothetical protein	U3PB67	Vibrio_phage	8.5e-31	33.3
AZU48477.1\|2613197_2613914_+	hypothetical protein	NA	NA	NA	NA
AZU48478.1\|2614027_2614309_+	hypothetical protein	NA	NA	NA	NA
AZU48479.1\|2614305_2616372_+	hypothetical protein	A5X9G4	Aeromonas_virus	2.7e-143	43.3
2623477:2623495	attR	NA	NA	NA	NA

DBSCAN-SWA_5

3035141 : 3065615

Escherichia_phage(37.5%)

transposase,integrase

attL 3028884:3028899|attR 3072363:3072378

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3028884:3028899	attL	NA	NA	NA	NA
AZU48871.1\|3035141_3036020_-\|transposase	transposase	Q9ZXG3	Shigella_phage	3.3e-106	67.0
AZU48872.1\|3035977_3036127_-	hypothetical protein	Q76S41	Shigella_phage	6.9e-17	85.7
AZU48873.1\|3037041_3037227_-\|transposase	transposase	NA	NA	NA	NA
AZU48874.1\|3037389_3037518_+	hypothetical protein	NA	NA	NA	NA
AZU48875.1\|3038032_3039520_-	endonuclease endonuclease/Exonuclease/phosphatase family protein	NA	NA	NA	NA
AZU48876.1\|3039562_3039679_-	ati2 chaperone	NA	NA	NA	NA
AZU48877.1\|3040256_3041174_-\|transposase	transposase	Q9MCT5	Escherichia_phage	1.6e-90	54.8
AZU48878.1\|3041597_3041915_-	iron ABC transporter	NA	NA	NA	NA
AZU48879.1\|3044366_3045290_-	iron-dicitrate transporter substrate-binding subunit	NA	NA	NA	NA
AZU48880.1\|3045376_3047515_-	ligand-gated channel	A0A0P0I887	Acinetobacter_phage	8.0e-05	27.1
AZU48881.1\|3047643_3049680_-	ligand-gated channel protein	NA	NA	NA	NA
AZU48882.1\|3049908_3051120_+	carboxylate--amine ligase	NA	NA	NA	NA
AZU48883.1\|3051116_3052934_+	siderophore synthetase component	NA	NA	NA	NA
AZU48884.1\|3052934_3054134_+	MFS transporter	NA	NA	NA	NA
AZU48885.1\|3054105_3055935_+	aconitase	NA	NA	NA	NA
AZU48886.1\|3055927_3057130_+	diaminopimelate decarboxylase	NA	NA	NA	NA
AZU48887.1\|3057522_3058899_-	heavy metal sensor histidine kinase	NA	NA	NA	NA
AZU48888.1\|3058934_3059606_-	two-component response regulator	W8CYM9	Bacillus_phage	8.3e-33	36.4
AZU48889.1\|3059852_3060254_+	hypothetical protein	NA	NA	NA	NA
AZU48890.1\|3060357_3060678_+	hydroxyisourate hydrolase	NA	NA	NA	NA
AZU48891.1\|3060873_3061011_-	hypothetical protein	NA	NA	NA	NA
AZU48892.1\|3061619_3062357_-\|transposase	putative transposase	A0A1V0E8E1	Vibrio_phage	6.2e-74	57.3
AZU48893.1\|3062585_3062708_-	DDE endonuclease	NA	NA	NA	NA
AZU48894.1\|3063136_3064159_+	hypothetical protein	A0A2L1IVA1	Escherichia_phage	8.2e-149	73.2
AZU48895.1\|3064158_3064938_+\|transposase	transposase	A0A2L1IVB6	Escherichia_phage	5.7e-126	88.4
AZU48896.1\|3065420_3065615_+\|integrase	integrase catalytic subunit	NA	NA	NA	NA
3072363:3072378	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP028418

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection