CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP035154	Pediococcus acidilactici strain SRCM103387 chromosome, complete genome	3 crisprs	cas9,cas1,cas2,csn2,DEDDh,DinG,cas3,csa3	2	17	5	0
CP035155	Pediococcus acidilactici strain SRCM103387 plasmid unnamed1	0 crisprs	NA	0	0	0	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: CP035154_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP035154_2

472999-474222

TypeII

Consensus_repeat	Method
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	PILER-CR
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CRISPRCasFinder
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CRT

18 spacers

csn2,cas2,cas1,cas9

The CRISPR arrays of CP035154_2

>merge|CP035154|2|472999-474222|PILER-CR,CRISPRCasFinder,CRT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCAACAATGTTCGGTACCGATGCGGTTCGTGCGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCGAAGCGGACATTGCTTCGGCAAAGGCGGAAGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCACCAAGCCATACCGCAGTAATGAAGGACGCGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCTGATTGATTAATCAATGTTTTAAGAATCGGGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCCTCAAATTGTTGAAGCGAATATTAAGTTCGGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCTCGGGAATGTCGTCAACTTCCGTGGCGTGTGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCCTACTGACTACAGCCTAACCCTAGGCTAACGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCACGTAGTCGGCATTATTAATACGGTATTGAGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCGAAGCAAATAAAAACACCAAAAAGGCGTCTGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCAAGATTGATTATGCAAGAATGACTGAAAAAGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCCCCATCAACAACCTAACACGGGGGCAAGGGGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCTTCATCATAATGTTGAATATAGGTATCCCTGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCTAGGCAGTGTTGCATTTGCCGCAATTCCGCGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCGATAGGCTTGGAAATGATAGATAACAACATGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCACCGAGAAGCAATACTTTGTCCCCTCATCTGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCATTTATCATAATTATATCCACTACTTAAATGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATCTCCCATCCTCCCAAAGCCAATTCGAGCGGAGTTTCAGAAGGATGTTAAATCAATAAGGTTAAGAGCGTGGCTGGTTAGTTTGGGTATCTAAGGGAGTTTTCAGAAGGGGAATAAAGTTAAATGGAAGTCATA

>CP035154|2|1|472999-473958|PILER-CR
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	AACAATGTTCGGTACCGATGCGGTTCGTGC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GAAGCGGACATTGCTTCGGCAAAGGCGGAA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ACCAAGCCATACCGCAGTAATGAAGGACGC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TGATTGATTAATCAATGTTTTAAGAATCGG
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CTCAAATTGTTGAAGCGAATATTAAGTTCG
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TCGGGAATGTCGTCAACTTCCGTGGCGTGT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CTACTGACTACAGCCTAACCCTAGGCTAAC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ACGTAGTCGGCATTATTAATACGGTATTGA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GAAGCAAATAAAAACACCAAAAAGGCGTCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	AAGATTGATTATGCAAGAATGACTGAAAAA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CCCATCAACAACCTAACACGGGGGCAAGGG
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTCATCATAATGTTGAATATAGGTATCCCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TAGGCAGTGTTGCATTTGCCGCAATTCCGC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GATAGGCTTGGAAATGATAGATAACAACAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC

>CP035154|2|1|472999-474156|CRISPRCasFinder
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	AACAATGTTCGGTACCGATGCGGTTCGTGC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GAAGCGGACATTGCTTCGGCAAAGGCGGAA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ACCAAGCCATACCGCAGTAATGAAGGACGC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TGATTGATTAATCAATGTTTTAAGAATCGG
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CTCAAATTGTTGAAGCGAATATTAAGTTCG
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TCGGGAATGTCGTCAACTTCCGTGGCGTGT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CTACTGACTACAGCCTAACCCTAGGCTAAC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ACGTAGTCGGCATTATTAATACGGTATTGA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GAAGCAAATAAAAACACCAAAAAGGCGTCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	AAGATTGATTATGCAAGAATGACTGAAAAA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CCCATCAACAACCTAACACGGGGGCAAGGG
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTCATCATAATGTTGAATATAGGTATCCCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TAGGCAGTGTTGCATTTGCCGCAATTCCGC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GATAGGCTTGGAAATGATAGATAACAACAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ACCGAGAAGCAATACTTTGTCCCCTCATCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ATTTATCATAATTATATCCACTACTTAAAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TCCCATCCTCCCAAAGCCAATTCGAGCGGA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGAGC

>CP035154|2|2|472999-474222|CRT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	AACAATGTTCGGTACCGATGCGGTTCGTGC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GAAGCGGACATTGCTTCGGCAAAGGCGGAA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ACCAAGCCATACCGCAGTAATGAAGGACGC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TGATTGATTAATCAATGTTTTAAGAATCGG
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CTCAAATTGTTGAAGCGAATATTAAGTTCG
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TCGGGAATGTCGTCAACTTCCGTGGCGTGT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CTACTGACTACAGCCTAACCCTAGGCTAAC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ACGTAGTCGGCATTATTAATACGGTATTGA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GAAGCAAATAAAAACACCAAAAAGGCGTCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	AAGATTGATTATGCAAGAATGACTGAAAAA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	CCCATCAACAACCTAACACGGGGGCAAGGG
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TTCATCATAATGTTGAATATAGGTATCCCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TAGGCAGTGTTGCATTTGCCGCAATTCCGC
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	GATAGGCTTGGAAATGATAGATAACAACAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ACCGAGAAGCAATACTTTGTCCCCTCATCT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	ATTTATCATAATTATATCCACTACTTAAAT
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGATC	TCCCATCCTCCCAAAGCCAATTCGAGCGGA
GTTTCAGAAGGATGTTAAATCAATAAGGTTAAGAGC	GTGGCTGGTTAGTTTGGGTATCTAAGGGAG
TTTTCAGAAGGGGAATAAAGTTAAATGGAAGTCATA

Protein	Signature genes	Signature genes Name	Protein_function
CP035154.1\|QAR86320.1\|458537_459659_+\|N-acetylmuramoyl-L-alanine-amidase	unknown	unknown	gnl\|CDD\|133475
CP035154.1\|QAR86330.1\|475673_476321_-\|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl\|CDD\|376806
CP035154.1\|QAR86326.1\|466824_470898_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	cas9	mkCas0193_cas9_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|374653
CP035154.1\|QAR86334.1\|480793_481969_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	unknown	unknown	gnl\|CDD\|133463
CP035154.1\|QAR86331.1\|476510_476795_+\|co-chaperone-GroES	unknown	unknown	gnl\|CDD\|178988
CP035154.1\|QAR86336.1\|482706_484026_+\|DNA/RNA-helicase	unknown	unknown	gnl\|CDD\|226583
CP035154.1\|QAR86322.1\|461024_461669_+\|SDR-family-oxidoreductase	unknown	unknown	gnl\|CDD\|187554
CP035154.1\|QAR86327.1\|471113_472019_+\|type-II-CRISPR-associated-endonuclease-Cas1	cas1	cd09720_cas1_CAS-II-A:CAS-II-B:CAS-II-C	gnl\|CDD\|187851
CP035154.1\|QAR86329.1\|472298_472970_+\|type-II-A-CRISPR-associated-protein-Csn2	csn2	cd12218_csn2_CAS-II-A	gnl\|CDD\|213411
CP035154.1\|QAR86335.1\|482036_482675_-\|YigZ-family-protein	unknown	unknown	gnl\|CDD\|224653
CP035154.1\|QAR86321.1\|459767_460034_+\|hypothetical-protein	unknown	unknown	unknown
CP035154.1\|QAR86337.1\|484825_485380_+\|ribosome-associated-translation-inhibitor-RaiA	unknown	unknown	gnl\|CDD\|224461
CP035154.1\|QAR86323.1\|461861_463271_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|129794
CP035154.1\|QAR86338.1\|485528_487892_+\|preprotein-translocase-subunit-SecA	unknown	unknown	gnl\|CDD\|237259
CP035154.1\|QAR86328.1\|471996_472302_+\|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0206_cas2_CAS-I:CAS-II:CAS-III	gnl\|CDD\|226043
CP035154.1\|QAR86332.1\|476817_478440_+\|chaperonin-GroEL	unknown	unknown	gnl\|CDD\|234573
CP035154.1\|QAR87755.1\|484310_484697_+\|ComF-family-protein	unknown	unknown	gnl\|CDD\|223970
CP035154.1\|QAR86324.1\|463297_465832_+\|M1-family-peptidase	unknown	unknown	gnl\|CDD\|341064
CP035154.1\|QAR86325.1\|466059_466641_-\|hypothetical-protein	unknown	unknown	gnl\|CDD\|371000
CP035154.1\|QAR86333.1\|478739_480572_+\|APC-family-permease	unknown	unknown	gnl\|CDD\|372624

Protein	Function_ID	Function_description	E-value
CP035154.1\|QAR86320.1\|458537_459659_+\|N-acetylmuramoyl-L-alanine-amidase	gnl\|CDD\|133475	cd06583, PGRP, Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 kDa) extracellular proteins; intermediate PGRPs (PGRP-I) that are 40-45 kDa and are predicted to be transmembrane proteins; and long PGRPs (PGRP-L), up to 90 kDa, which may be either intracellular or transmembrane. Several structures of PGRPs are known in insects and mammals, some bound with substrates like Muramyl Tripeptide (MTP) or Tracheal Cytotoxin (TCT). The substrate binding site is conserved in PGRP-LCx, PGRP-LE, and PGRP-Ialpha proteins. This family includes Zn-dependent N-Acetylmuramoyl-L-alanine Amidase, EC:3.5.1.28. This enzyme cleaves the amide bond between N-acetylmuramoyl and L-amino acids, preferentially D-lactyl-L-Ala, in bacterial cell walls. The structure for the bacteriophage T7 lysozyme shows that two of the conserved histidines and a cysteine are zinc binding residues. Site-directed mutagenesis of T7 lysozyme indicates that two conserved residues, a Tyr and a Lys, are important for amidase activity.	9.06637e-13
CP035154.1\|QAR86330.1\|475673_476321_-\|CPBP-family-intramembrane-metalloprotease	gnl\|CDD\|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	7.36095e-10
CP035154.1\|QAR86326.1\|466824_470898_+\|type-II-CRISPR-RNA-guided-endonuclease-Cas9	gnl\|CDD\|374653	pfam16592, Cas9_REC, REC lobe of CRISPR-associated endonuclease Cas9. The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defense against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.	4.07097e-143
CP035154.1\|QAR86334.1\|480793_481969_+\|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase	gnl\|CDD\|133463	cd06853, GT_WecA_like, This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate molecule and N-acetylglucosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylglucosamine precursor. WecA participates in the biosynthesis of O antigen LPS in many enteric bacteria and is also involved in the biosynthesis of enterobacterial common antigen. A conserved short sequence motif and a conserved arginine at a cytosolic loop of this integral membrane protein were shown to be critical in recognition of substrate UDP-N-acetylglucosamine.	4.92655e-87
CP035154.1\|QAR86331.1\|476510_476795_+\|co-chaperone-GroES	gnl\|CDD\|178988	PRK00364, groES, co-chaperonin GroES; Reviewed.	1.42388e-45
CP035154.1\|QAR86336.1\|482706_484026_+\|DNA/RNA-helicase	gnl\|CDD\|226583	COG4098, comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair].	1.46352e-172
CP035154.1\|QAR86322.1\|461024_461669_+\|SDR-family-oxidoreductase	gnl\|CDD\|187554	cd05243, SDR_a5, atypical (a) SDRs, subgroup 5. This subgroup contains atypical SDRs, some of which are identified as putative NAD(P)-dependent epimerases, one as a putative NAD-dependent epimerase/dehydratase. Atypical SDRs are distinct from classical SDRs. Members of this subgroup have a glycine-rich NAD(P)-binding motif that is very similar to the extended SDRs, GXXGXXG, and binds NADP. Generally, this subgroup has poor conservation of the active site tetrad; however, individual sequences do contain matches to the YXXXK active site motif, the upstream Ser, and there is a highly conserved Asp in place of the usual active site Asn throughout the subgroup. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	2.11328e-42
CP035154.1\|QAR86327.1\|471113_472019_+\|type-II-CRISPR-associated-endonuclease-Cas1	gnl\|CDD\|187851	cd09720, Cas1_II, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer intergration. Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	2.86873e-99
CP035154.1\|QAR86329.1\|472298_472970_+\|type-II-A-CRISPR-associated-protein-Csn2	gnl\|CDD\|213411	cd12218, Csn2, CRISPR/Cas system-associated protein Csn2. Csn2 is a Nmeni subtype-specific Cas protein, which may function in the adaptation process which mediates the incorporation of foreign nucleic acids into the microbial host genome. Csn 2 may interact directly with double-stranded DNA. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA. Csn2 has been predicted to be a functional analog of Cas4 based on anti-correlated phyletic patterns; also known as SPy1049 family.	3.07299e-100
CP035154.1\|QAR86335.1\|482036_482675_-\|YigZ-family-protein	gnl\|CDD\|224653	COG1739, COG1739, Uncharacterized conserved protein [Function unknown].	4.15849e-58
CP035154.1\|QAR86332.1\|476817_478440_+\|chaperonin-GroEL	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
CP035154.1\|QAR86337.1\|484825_485380_+\|ribosome-associated-translation-inhibitor-RaiA	gnl\|CDD\|224461	COG1544, COG1544, Ribosome-associated protein Y (PSrp-1) [Translation, ribosomal structure and biogenesis].	2.37568e-37
CP035154.1\|QAR86323.1\|461861_463271_+\|MFS-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	9.30964e-48
CP035154.1\|QAR86338.1\|485528_487892_+\|preprotein-translocase-subunit-SecA	gnl\|CDD\|237259	PRK12904, PRK12904, preprotein translocase subunit SecA; Reviewed.	0
CP035154.1\|QAR86328.1\|471996_472302_+\|CRISPR-associated-endonuclease-Cas2	gnl\|CDD\|226043	COG3512, COG3512, CRISPR-associated protein, Cas2 homolog [Defense mechanisms].	3.63081e-29
CP035154.1\|QAR87755.1\|484310_484697_+\|ComF-family-protein	gnl\|CDD\|223970	COG1040, ComFC, Predicted amidophosphoribosyltransferases [General function prediction only].	1.86727e-22
CP035154.1\|QAR86324.1\|463297_465832_+\|M1-family-peptidase	gnl\|CDD\|341064	cd09601, M1_APN-Q_like, Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1). This M1 peptidase family includes eukaryotic and bacterial members: the catalytic domains of aminopeptidase N (APN), aminopeptidase Q (APQ, laeverin), endoplasmic reticulum aminopeptidase 1 (ERAP1) as well as tricorn interacting factor F3. Aminopeptidase N (APN; CD13; alanyl aminopeptidase; EC 3.4.11.2), a type II integral membrane protease, preferentially cleaves neutral amino acids from the N-terminus of oligopeptides and is present in a variety of human tissues and cell types (leukocyte, fibroblast, endothelial and epithelial cells). APN expression is dysregulated in inflammatory diseases such as chronic pain, rheumatoid arthritis, multiple sclerosis, systemic sclerosis, systemic lupus erythematosus, polymyositis/dermatomyosytis and pulmonary sarcoidosis, and is enhanced in tumor cells such as melanoma, renal, prostate, pancreas, colon, gastric and thyroid cancers. It is considered a marker of differentiation since it is predominantly expressed on stem cells and on cells of the granulocytic and monocytic lineages at distinct stages of differentiation. Thus, APN inhibition may lead to the development of anti-cancer and anti-inflammatory drugs. ERAP1, also known as endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP), adipocyte derived leucine aminopeptidase (A-LAP), or aminopeptidase regulating tumor necrosis factor receptor I (THFRI) shedding (ARTS-1), associates with the closely related ER aminopeptidase ERAP2, for the final trimming of peptides within the ER for presentation by MHC class I molecules. ERAP1 is associated with ankylosing spondylitis (AS), an inflammatory arthritis that predominantly affects the spine. ERAP1 also aids in the shedding of membrane-bound cytokine receptors. The tricorn interacting factor F3, together with factors F1 and F2, degrades the tricorn protease products, producing free amino acids, thus completing the proteasomal degradation pathway. F3 is homologous to F2, but not F1, and shows a strong preference for glutamate in the P1' position. APQ, also known as laeverin, is specifically expressed in human embryo-derived extravillous trophoblasts (EVTs) that invade the uterus during early placentation. It cleaves the N-terminal amino acid of various peptides such as angiotensin III, endokinin C, and kisspeptin-10, all expressed in the placenta in large quantities. APN is a receptor for coronaviruses, although the virus receptor interaction site seems to be distinct from the enzymatic site and aminopeptidase activity is not necessary for viral infection. APNs are also putative Cry toxin receptors. Cry1 proteins are pore-forming toxins that bind to the midgut epithelial cell membrane of susceptible insect larvae, causing extensive damage. Several different toxins, including Cry1Aa, Cry1Ab, Cry1Ac, Cry1Ba, Cry1Ca and Cry1Fa, have been shown to bind to APNs; however, a direct role of APN in cytotoxicity has been yet to be firmly established.	0
CP035154.1\|QAR86325.1\|466059_466641_-\|hypothetical-protein	gnl\|CDD\|371000	pfam10351, Apt1, Golgi-body localization protein domain. This is the C-terminus of a family of proteins conserved from plants to humans. The plant members are localized to the Golgi proteins and appear to regulate membrane trafficking, as they are required for rapid vesicle accumulation at the tip of the pollen tube. The C-terminus probably contains the Golgi localization signal and it is well-conserved.	0.00039108
CP035154.1\|QAR86333.1\|478739_480572_+\|APC-family-permease	gnl\|CDD\|372624	pfam13520, AA_permease_2, Amino acid permease.	4.05738e-28

>CP035154.1|QAR86329.1|472298_472970_+|type-II-A-CRISPR-associated-protein-Csn2
MKLTYRTHEPVEIKPHAITVLGTNNSTVYTDLVNGMQERNELILAFDENYKELEISKVFDWIGDVGTQDLVIQKYLTKIERVFAEGLMDEQRNQIHDQVNQLFNTVAEQLFMLDLPISVNYDFDLKKLLKYCGVHFDPLSVGNPYGIIEAILKIHEECAINSCVVLTDVAHYLTATQIEELTQLVSQTNQALLLIEFTEIGNQEAYGNSEFYYIDNDFVDWHQ
>CP035154.1|QAR86328.1|471996_472302_+|CRISPR-associated-endonuclease-Cas2
MRLMIMFDLPVETAVQRKQYRQFRKALINEGFLMIQYSVYVRVCVNKKSATFMENRIKTYLPENGTIQALTLTEKQYNDMHFLVGERVKDVRNTSDRTVIL
>CP035154.1|QAR86327.1|471113_472019_+|type-II-CRISPR-associated-endonuclease-Cas1
MGWRSVIITQHAKLSYSAHAMIVQTNDGINQIPVDDVSLLLISTTQAVITTALISELSKKNVKIVFTDEAREPISEIYGYYPANRTAQLLREQVNWDLQLQQILWTKLVANKIINQINVLNLLEHSTDELVTELEKLELNDLTNREAVVAHKYFPLLFESGFTRRDGSVINAALNYGYSILLSAVNQEIVANGYVTYLGIHHDSEENQFNLASDLMEPFRPVVDCWVANQKFNQLTPDIKYGLVELLSLELKYNGKKMILRNAITDHVRNCLKYLAGKANSFTIEMELSDEVPNNAINDNV
>CP035154.1|QAR86326.1|466824_470898_+|type-II-CRISPR-RNA-guided-endonuclease-Cas9
MGDRKYNLGLDIGTSSIGFAAVDENNQPIRVKGKTAIGVRLFEEGKTAADRRGFRTTRRRLSRRRWRINLLNGIFDAHLAEVDPTFLARLKESNRSNLDPKKSFQGSLLFPERKDYQFYKEYPTIYHLRKALMEKDRKFDIREIYLAVHHIIKYRGNFLNGTPMRSFKVENIELDTLFDRLNQLYEEIIPDNELAFDLEQVADVKEVLSSTTIYKMDKKKQLVKMMLLPASNKALQSENKKIVTQFVNAILNYKFKLDVLLQVETDADWSLKLNDEGADDKLEEFTGDLDENRLEIIDLLQRLHNWFSLNEITKDGNSLSAAMVEKYKDHRHHLELLKKVIEDHPDAKKAKALKETYTAYVGKTDDKTQNQDDFYKAVEKNLDDSPDAKEIKRLIQLDQFMPKQRTGQNGAIPHQLHQQELDQIIEKQSKYYPFLAEPNPNVNRRKDAPYKLDELIAFKIPYYVGPLVTPEEQAQNGENVFAWMKRKAAGPITPWNFDKKVDRMESANRFIRRMTTKDTYLFGEDVLPAESMIYEKFVVLNELNNLKINGRHLSLKDKQDIYNDLFKQQKTVSIKALQNYYVTKKKAATAPTVGGLADPKKFLSSLSTYIDFKNMFGERVNDPQFQENLEQIVEWSTIFEDRGIFKAKLQALGWLSEKQIQQLVAKRYKGWGRLSKKLLTGLKNAEGYSIFDEMWRSTENFMQIQSRPEFAALIQQANEKQFEGNDPNNVWENIENILGDAYTSPQNKKAIRQVVKVVQDIEKAVGNPPEKIAIEFTREAAANPQRTQSRLRTLEKLYESAEEVVDAGLTAELAEFKENKHVLSDKYYLYFTQLGRDVYTGDTISLDRLNDYDVDHILPQSFIKDDSLDNRVLTIRAVNNGKSDNVPAKMFGKKMGSFWRYLLDNGMISKRKYNNLITDPDNISKYAQKGFINRQLVETSQVIKLTANILNGIYDKDTEIIEVPAKMNSQMRKMFDLVKVREVNDYHHAFDAYLTIFIGNYLYKCYPKLRPYFVYDNFKKFGNKEDIGHKRFNFLGKIERDKKVVAPETGEILWSNVAPNETIKQIKKVYDYKFMLTSHETYTKHGALFNQTIYSAKASKTMIPIKNDRPTRLYGGYSGNEDAYMSIIRLSDKKKTYKVVGISMRDASKLKAYENNAHEEYLKKLKEVIEQQFLDSGKKTKADFEIVIPKVNYHQRMQDGTKQFRIGSSKYVHNTKQLVLSEKTLKAIRNNKQYNGDAEKDLINAFDEILTIVNDSFSIFDIRSFRKKLNESRDKFVSLPVEDTKEKSKVIKGKRETLKQILIALHANGTSQDIPQLGLKSFGKMVKTGGLTLSENTVLIHQSPSGLFERKIKLSDL
>CP035154.1|QAR86325.1|466059_466641_-|hypothetical-protein
MKKIASIAILAVLPLTLASCGNHSTSNSDTSSNSSKTEKVAKSSSKSSVSKDAKSSSDDKATSSSASANSSKDSTNSNSSSSSNSASSSTSSATDSSSSADNQMSRSDLTKAEKKNGNRPLADEKIQNEQAAVALLTEKYGNQNWKVAFSSIGKSSPIYFHITSPKHGSYYVYANGDVQSADGDLSNHQIVNK
>CP035154.1|QAR86324.1|463297_465832_+|M1-family-peptidase
MANIERFYTKFHPTNYQIKLAISRETKEIKGTTTITGEALSSQIDIHQKDLQIEELRVDGTAGDFTVDQAAEAIHVKLPHTGTVTLEIKYTTKLTDTMMGIYPSYYEVNGETKQLVGTQFETTFARQAFPCVDEPEAKATFDLAIKFDEHPGEVVLSNMPETKVEDGYHYFARTVKMSTYLIAFAFGDLQSKQTKTKSGVQVGVFATKAHQPQELDFALDIAKRAIEFYEDFYQTPYPLPHSWQLALPDFSAGAMENWGLVTYREAYLLLDPKNTTLRTKQVVATVIAHELAHQWFGDLVTMQWWDDLWLNESFANMMEYVAVDALEPEWQIWELFQNSEAGAALQRDATDGVQSVHVQVNDPAEIDALFDGAIVYAKGARMLVMVRALIGDDALRQGLQKYFASHQYGNATGNDLWQALGEAANMPIGDIMHTWLDQPGYPVVTAQVENGDLVLEQQQFFIGEGQAQQRQWQIPLNGNYAEVPALLQTKTLNLGNHQDLRDRNQQPFRLNVGNSSHFIVRYDQRLLDDILADWEQLSAIDQLQLLQDLRLLAEGKQISYAEIVPLLPRFAKTDSALVTEMLYRVANDLKKFVAPQSSAEKQLKKFFGELSQAPAQRLGWQAAAGETNDDQLMRPMVLKAALYAENPAVTAQAHQLFEENEAQLSKLPAAIRSLVIRNEVEHFGSPELFARLLKEYQRTSDASYKSDLCQALTATPSLPLIQQLVQQFENAQVIKPQDLRAWFRGVLANPQGQGPAWNWIRDEWQWLEDTVGGDMEFATYITVIAGIFQTPTRLAEFKAFFEPKLATPGLTREITMDIKVIETRVALIETERDAVQAAVVQAIK
>CP035154.1|QAR86323.1|461861_463271_+|MFS-transporter
METQNTRHTNPMIVVAVVALMSFMGILTETSMNVTFPALMKEFHVPLNTVQWVTAGYLLMAALVMLTSAYMKRRFTNRQLFTAAAILFSSGDLICGLATNFWVLLAGRLIQAGCVGLCTPLMVNIILDVVPQHKLGTYIGMANLIILIAPALGPTFGGAVVAFNSWRMIFWSTLPVALVLMLLGMKVIKQYAPTDQHYAFDWTRFLLLGMALVSLIVGLNALGEMQLGTFVGLLIVSIGLTMLFVKRSHTATKALFSLQVFKQPAFLYSFLPYIMLQFANVGINFLLPNYVQDVFQATSLVGGLILLPGSLFNGFGQPLYGWLLDRFGGKVPLYTGDILFTLALVGLMCWGPQLGVVGITIAYLIFAIGRSMAFGNSVAYGLKHIDKEFQNDANALYNTGQQVTGAIGTTVLALLMGSVKRPGYTHAQNVSAGSQLAFILLVIFGCVIFVFFHHLVNLKNLPEDKGVDL
>CP035154.1|QAR86322.1|461024_461669_+|SDR-family-oxidoreductase
MAKIFIAGGSGRVATALIKNLVADGNEVVAGARHPENVVEMDHVSAVKLDLHDGVDAIADLMKGSDAVYFTAGSRGADLLQTDAMGAVKTMQAAEKLGIKRYVMLSSLYTLESERKWHEGGLADLLDYTTAKFFADNYLVHDTDLDYTIVQPTSLTEEAGTGQIYIGKELPQKTNPIPDVARVLADVLKHPNTVKKVFMMSSGSQAIDQALANV
>CP035154.1|QAR86321.1|459767_460034_+|hypothetical-protein
MNKDVKIILERIQEHFKRVPNTIYKINVVDDRFDKCYNFFIYIEKRGKRPHSIPLRTIKNYDIDYLKEVISGIKEHYQLTFTYTGFTE
>CP035154.1|QAR86320.1|458537_459659_+|N-acetylmuramoyl-L-alanine-amidase
MKLKNKLIAGLVAGAAAFFVGLNQQVSAATINNDYALSESEGSPLRTNNNVIIAHATAVYAPARNVATYEKREWYNAGAYVQYIVGDGGKIYRVGAEGYQAWGAGSWANANAPVQVELAQTYDQAEFRKDYVTYVNLLRSSAIKYGIPTTVDSGAWRGVKSHLWVTNHVWGDHTDPYGYLASHGITKAQFAHDVQYGFSSSGNDVTPTPKPTPKPVKPANKKQVDVTYAMHQRNGRWLSPVKNAGSGANGFAGMPYSAHDMLYIKVNRGSIKYRVHTREDGWLPWVHKANKNDTVNGVAGIKGHTIDGVQMYYTTPSGETYQQAYYRSQSTQRAGYLGTCADNGSVAGYDSWAGMYGEPLDRLQISINDHSNF
>CP035154.1|QAR86330.1|475673_476321_-|CPBP-family-intramembrane-metalloprotease
MKISKSSLLTLITYLAIFLLPSVINLFVRLGASFIWVETIDYLVGAALLLIINLKNSEINQIETRRIPFFRAIAWGIIGTALVIVLQFVVSYVTFILGQNPASANTATLVTLAKINPFFVLAITVGAPIMEELVFRKVLFGNLSTLFGMRSNLGLTIMAIISSLAFAFMHNDSHIFLYAAIGLLFCWLYHKTGRIQTSMIAHILMNGLVVLPLVM
>CP035154.1|QAR86331.1|476510_476795_+|co-chaperone-GroES
MLKPLGDRVILEAKDEEEQTVGGIVLASNAKEKSQTGKVVAVGNGRVLDDGKTLPMNVKVGDTVVYDKYAGTEVTYEDQKYLVVHEKDLVAVVE
>CP035154.1|QAR86332.1|476817_478440_+|chaperonin-GroEL
MAKEIKFSEDARTKMLKGVDKLADTVKSTIGPKGRNVVLEQSYGSPTITNDGVTIAKSIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVNEGMKNVTAGANPVGIRRGIEKATEKAVAALHNMSHEVKTKDDIAQIASISSANPEVGKLIADAMEKVGNDGVITIEESRGVDTTLDVVEGMQFDRGYMSQYMVTDNDKMEANLDNPYILITDKKIANIQDILPLLQSVVEQSRSLLIIADDITGEALPTLVLNKMRGTFNVVAVKAPGFGDRRKEQLEDIAILTGGTVITDDLGLNLKDVTIEQLGQANKVTVTKDDTTIVEGSGSQEQIAERVAMIKQQISETTSDFDKEKLQERLAKLAGGVAVIRVGAATETELKEKKYRIEDALNATRAAVEEGFVPGGGTALVNVIASLEDLDAEGDELTGINIVRRALEEPVRQIAENAGEEGSVIVTKLKTQKDGVGYNAATDEWVDMIEAGIVDPTKVTRSALQNAASVSALLLTTEAVVADLPEEKPAAPAAPNPGMGGMM
>CP035154.1|QAR86333.1|478739_480572_+|APC-family-permease
MFSYLKRILIGKPLKTLDESGQALTKFKALALLSSDALSSIAYGTEEILSVLIVLSAAATWYSIPIAAIVLVLLFAITVSYRQIIKAYPSGGGAYVVASKNWGTSAGLVAGGSLLVDYMLTVAVSVTSGTEAITSAIPALQKYHVAIAVLIVLGIMALNLRGLRESASFLTIPVYLFVVVISIMIIVGLYNIVTGQVTYHAAAAIGSTVPGMTFVLFMRALSSGSSSLTGVEAISNAVPNFKKPRRKNAAATLAIMSLILASFFAGITFLAYYSGITPMSSQTVLSQIGVTVFGHGIFYYILQLSTALILAVAANTGFSAFPMLAYNLAKDKFMPHAYMDRGDRLGYSNGIISLAAGAIVLILIFGGQTGLLIPLYAIGVFVPFTLSQSGMIVHWKREGGAHWWINASANLLGALLSAVLVVCLLFLHFSNVWPYFVVMPLLLRMFYKIRKHYDEVADQLRVVEKGKVNLHDYDGSTVIVLVSNVTQVTSGAINYARSIGDYVIAMHVSFDANPEKEHKTAMEFKAEYPDVRFIDIHSSYRSITNPTLRFCDVIAKRAAERNYTTTVLVPQFVPRKPWQNILHNQTGLRLRAALNSRENIIVSTYNYHLK
>CP035154.1|QAR86334.1|480793_481969_+|undecaprenyl/decaprenyl-phosphate-alpha-N-acetylglucosaminyl-1-phosphate-transferase
MRFEIVVSLFATMIISAILTPFVRRIAFKIGAVDKPNARRVNKVPMPTMGGLAIFLAFNFSLFFLLRNQIPNPQFYGIFFGECIIMLTGIIDDIFELKPSQKMIGILLAALAVYWFAEVQMTTLTLPFIGIVHLGWFSLPITLIWIAAITNAINLLDGLDGLATGVTIIALFTTGFTGLFFLPSTNIYIVIMIFTLVAAEVGFLPYNFFPARIYLGDTGALFIGFMIAVFSLSGLKNATFISVLIPVMILGVPLTDTIYAILRRLLNKQSIAHADKRHLHHRLMQMGLTHRQTVLVIYGISMIFSFIALLYPLSTLWGSVLLTIGILVGIELFVEAIGLVGENRTPMLSWIKRLVRTTTSKTASNEFKEEDTLKDRVRSRSERHQQKKHHD
>CP035154.1|QAR86335.1|482036_482675_-|YigZ-family-protein
MKLILSVKEPVTTEQDIKKSRFISRIIPVQTEEEAQTKLQDIREIEAKATHNCFAYVLGDHQDIQRASDDGEPSGTAGAPILEVLKRENLTNVLVVVTRYFGGIKLGAGGLIRAYGSSTSLAVQSATLMESVDQELLAITIDYQNNDQLTYYLEQHQITQVNHEYTTQVITTVAVDQDQVADLKAELTGLFSGNVSFKDGGQQRVQVPYQPQ
>CP035154.1|QAR86336.1|482706_484026_+|DNA/RNA-helicase
MEAKVKEKYYGRLVPVNQAEATDPTVNYFPAVIVKKRRIQCQRCGATTKLKEGSLPNQQYYCRHCINLGRMSTLVKLGNLPEPNHFPVGRSYLKWQGQLTPDQQRCANEIISSIKQQTDRLLWAVTGAGKTEMLFPGINFALKKALRVAIASPRIDVVLELHPRIQAAFPEIAITLLHGRTSAPYTYTQLVLCTTHQLLRFYHAFDVLIIDEVDSFPFAMNPALHYAAHQARKECGTTIYLTATPDGQLLKDSRSHRLPTSYLTRRFHGHPLPEIKMVSGCNWQKLIHRRRLPERLRQFLMAQAKAQRQFLVFVPRIDQLSSVLQAIQKQFPELDLATVYAEDPDRIEKVSAMREGQLTGLITTTILERGVTFPGIDVAVLGADDEIFSMAALVQIAGRVGRSPKRPTGTVLFIGQMLTRRIKRAQRQVKFMNQQAFKQ
>CP035154.1|QAR87755.1|484310_484697_+|ComF-family-protein
MRKAFCNDFINFIQSLVKEDEHLVPIPVDQGTIKVRGFNQVAGLIEGLEFEPVLISQRSEQARHQFQRSRRERLQRENPFRVVEPNKVAGAKWVIIDDIYTTGVTVRQAERELSKHGARQVRSITLCR
>CP035154.1|QAR86337.1|484825_485380_+|ribosome-associated-translation-inhibitor-RaiA
MLDFNVRGENIEVTESIRDYVEKRIGKIEKYFDQGANPKAHVNLKVYQDRTAKVEVTIPLPYLVLRAEETSPDLYASVDLVTDKLERQIRKYKTKINRKSRETGYKGVEIPQEDAREDEEEASEFDIVRTKQVSLKPMGAEEAILQMDMLGHNFFIYEDADTGSVDIVYRRHDGRYGLIESANE
>CP035154.1|QAR86338.1|485528_487892_+|preprotein-translocase-subunit-SecA
MANILKKWVESDAREIKRLGKKADKIDALKDEMAQLSDEELKAKTPEFKERLKNGETLDDILIEAFAVAREGAKRVLGLFPFRVQLIGGMVLHGGNIAEMKTGEGKTLTATLPVYLNALGGEGVHVVTVNEYLAERDSTEMGELYKWLGLTVGVNTAEMSPDEKREAYNCDITYSTNSEIGFDYLRDNMVVYKEDMVQRPLNFALIDEVDSVLIDEARTPLIISGQTEPSVTLYQRADRFVKTLTDGDYTIDWESKSISLTENGIRRGEKYFNTDNLYDVENSALNHHIDQALRANYIMTKDKDYVVSDDGEVLIVDSFTGRVMEGRRFSDGLHQAIEAKEHVEIQDGSKTMANITYQNLFRMYKKLSGMTGTAQTEAEEFREIYNMEVVSVPTNRPVVRDDRPDLLYPTLESKFKAVVKEIKKLHTKGQPVLVGTVAVETSEYLSRLLDRERIPHVVLNAKNHAREAEIVANAGQKGAVTIATNMAGRGTDIKLGPGVVELGGLAVIGTERHESRRIDNQLRGRSGRQGDVGMSQFYLSLEDDLMIRFGSERIKDLLSRMKVADEDAVIQSRLISRQVESAQKRVEGNNYDARKNVLQYDDVMRAQREVIYAERQQVIMEEHSLKDVLMPMVYRTIDRVVDAHTAKTKKSYDLDTIVEFARTTLVNENDINIEDLEGKSANEIKDYLKQLADQMYKQKEDALYAPEQILEFEKVVILRVVDQHWTDHIDAMDQLRQSVGLRGYGQLNPLVEYQQEGYRMFNEMVTDIEYETTRLFMKSEIRQNLER

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Crispr_ID: CP035154_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP035154_3

718983-719086

Orphan

Consensus_repeat	Method
TTAGCTCAGTTGGGAGAGCATCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of CP035154_3

>merge|CP035154|3|718983-719086|CRISPRCasFinder
TTAGCTCAGTTGGGAGAGCATCTGCCTTACAAGCAGGAGGTCACAGGTTCGAGCCCTGTATCCTCCATTATCTTGAGCCGTTAGCTCAGTTGGTAGAGCATCTG

>CP035154|3|2|718983-719086|CRISPRCasFinder
TTAGCTCAGTTGGGAGAGCATCTG	CCTTACAAGCAGGAGGTCACAGGTTCGAGCCCTGTATCCTCCATTATCTTGAGCCG
TTAGCTCAGTTGGTAGAGCATCTG

Protein	Signature genes	Signature genes Name	Protein_function
CP035154.1\|QAR86558.1\|730785_731505_+\|rRNA-pseudouridine-synthase	unknown	unknown	gnl\|CDD\|211327
CP035154.1\|QAR86550.1\|711339_712356_+\|glycosyltransferase	unknown	unknown	gnl\|CDD\|340831
CP035154.1\|QAR86552.1\|721906_723097_+\|methionine-adenosyltransferase	unknown	unknown	gnl\|CDD\|235374
CP035154.1\|QAR86547.1\|707465_709190_+\|phosphoenolpyruvate--protein-phosphotransferase	unknown	unknown	gnl\|CDD\|224006
CP035154.1\|QAR86543.1\|703243_704221_+\|GMP-reductase	unknown	unknown	gnl\|CDD\|235479
CP035154.1\|QAR86542.1\|701885_702137_+\|hypothetical-protein	unknown	unknown	unknown
CP035154.1\|QAR86546.1\|707199_707466_+\|phosphocarrier-protein-HPr	unknown	unknown	gnl\|CDD\|237503
CP035154.1\|QAR86549.1\|710121_711309_+\|glycosyltransferase-family-4-protein	unknown	unknown	gnl\|CDD\|340844
CP035154.1\|QAR86556.1\|726418_728836_+\|leucine--tRNA-ligase	unknown	unknown	gnl\|CDD\|234743
CP035154.1\|QAR86559.1\|731611_732442_-\|NAD(P)H-hydrate-dehydratase	unknown	unknown	gnl\|CDD\|238576
CP035154.1\|QAR86555.1\|725377_726013_-\|phosphatase-PAP2-family-protein	unknown	unknown	gnl\|CDD\|239486
CP035154.1\|QAR86544.1\|704445_706653_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	unknown	unknown	gnl\|CDD\|223616
CP035154.1\|QAR86557.1\|729092_730775_+\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|240529
CP035154.1\|QAR86553.1\|723272_724742_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|341045
CP035154.1\|QAR87764.1\|712402_713407_+\|flippase-like-domain-containing-protein	unknown	unknown	gnl\|CDD\|377103
CP035154.1\|QAR86551.1\|721003_721735_-\|hypothetical-protein	unknown	unknown	unknown
CP035154.1\|QAR86548.1\|709262_710036_+\|alpha/beta-hydrolase	unknown	unknown	gnl\|CDD\|223669
CP035154.1\|QAR86554.1\|724821_725385_-\|methyltransferase-domain-containing-protein	unknown	unknown	gnl\|CDD\|377744
CP035154.1\|QAR86545.1\|706868_707057_+\|hypothetical-protein	unknown	unknown	unknown
CP035154.1\|QAR86560.1\|732567_733029_+\|universal-stress-protein	unknown	unknown	gnl\|CDD\|366180

Protein	Function_ID	Function_description	E-value
CP035154.1\|QAR86550.1\|711339_712356_+\|glycosyltransferase	gnl\|CDD\|340831	cd03801, GT4_PimA-like, phosphatidyl-myo-inositol mannosyltransferase. This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.	3.40373e-35
CP035154.1\|QAR86553.1\|723272_724742_+\|DHA2-family-efflux-MFS-transporter-permease-subunit	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	8.2669e-65
CP035154.1\|QAR86547.1\|707465_709190_+\|phosphoenolpyruvate--protein-phosphotransferase	gnl\|CDD\|224006	COG1080, PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism].	0
CP035154.1\|QAR86543.1\|703243_704221_+\|GMP-reductase	gnl\|CDD\|235479	PRK05458, PRK05458, guanosine 5'-monophosphate oxidoreductase; Provisional.	0
CP035154.1\|QAR86546.1\|707199_707466_+\|phosphocarrier-protein-HPr	gnl\|CDD\|237503	PRK13780, PRK13780, phosphocarrier protein HPr; Provisional.	7.13708e-55
CP035154.1\|QAR86549.1\|710121_711309_+\|glycosyltransferase-family-4-protein	gnl\|CDD\|340844	cd03817, GT4_UGDG-like, UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins. This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.	8.27925e-139
CP035154.1\|QAR86556.1\|726418_728836_+\|leucine--tRNA-ligase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
CP035154.1\|QAR86555.1\|725377_726013_-\|phosphatase-PAP2-family-protein	gnl\|CDD\|239486	cd03392, PAP2_like_2, PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.	4.2342e-49
CP035154.1\|QAR86544.1\|704445_706653_-\|ATP-dependent-Clp-protease-ATP-binding-subunit	gnl\|CDD\|223616	COG0542, clpA, ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones].	0
CP035154.1\|QAR86558.1\|730785_731505_+\|rRNA-pseudouridine-synthase	gnl\|CDD\|211327	cd02553, PseudoU_synth_RsuA, Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. E.coli RsuA makes psi516 in 16S RNA. Psi at this position is not generally conserved in other organisms.	1.16351e-86
CP035154.1\|QAR86559.1\|731611_732442_-\|NAD(P)H-hydrate-dehydratase	gnl\|CDD\|238576	cd01171, YXKO-related, B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.	3.79718e-74
CP035154.1\|QAR87764.1\|712402_713407_+\|flippase-like-domain-containing-protein	gnl\|CDD\|377103	pfam03706, LPG_synthase_TM, Lysylphosphatidylglycerol synthase TM region. LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defencins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.	1.83962e-32
CP035154.1\|QAR86552.1\|721906_723097_+\|methionine-adenosyltransferase	gnl\|CDD\|235374	PRK05250, PRK05250, S-adenosylmethionine synthetase; Validated.	0
CP035154.1\|QAR86548.1\|709262_710036_+\|alpha/beta-hydrolase	gnl\|CDD\|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	9.55615e-31
CP035154.1\|QAR86554.1\|724821_725385_-\|methyltransferase-domain-containing-protein	gnl\|CDD\|377744	pfam06962, rRNA_methylase, Putative rRNA methylase. This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.	1.26385e-70
CP035154.1\|QAR86557.1\|729092_730775_+\|polysaccharide-biosynthesis-protein	gnl\|CDD\|240529	cd13124, MATE_SpoVB_like, Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins. The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).	1.8869e-140
CP035154.1\|QAR86560.1\|732567_733029_+\|universal-stress-protein	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	1.49532e-25

>CP035154.1|QAR87764.1|712402_713407_+|flippase-like-domain-containing-protein
MILAGLVIFGYSLRGVNLHQVSHDILNLNVGWLLVALLCIILYLGFEAVATKVLVESNGDRLSWKDAIRIPLIEQLFNGLTPFSSGGQPAQLVALMQSGIEGGRASSVLLMKFVVFQSMVVLNFIFSLLIGFQYLEDKIKFLSWFVLFGFLIHLAVIIGLLMIMYWHNFTKKMFDLIFIPIKRFTKPERYLRWKTSIDAKVDTFYLESVRMKSQWRLLAKVALLTFLQLLFYYLIPYFILLALGKTHVHLIMVTCLHVLIFMVISLFPIPGGAGGAEYGFSVIFAQFVGNSSKLVLAMIIWRLLTYYFGMFAGMFATVIKPNRINRIAPKKTSE
>CP035154.1|QAR86550.1|711339_712356_+|glycosyltransferase
MPIKVNMFSSASKVKGQGVGSAYEELIRLLKTHFPKEIDLSINRYTQADISHYHTIDPQFFASTFTKKRGVKVGYVHFLPETIEGSLKIPQPFRWLFYKYIIAFYKRMDQIVVVNPTFIDQLVKYGIKREIITYIPNFVRKDEFYQYDAEQRRQVRERLGVQNRFTILGIGQVQERKGVKDFIKLAQQHPEMYFIWAGGFSFGRLTDGYADLKKVVDNPPANLKFTGIVDRNKLVEYYNAADLFLLPSYNELFPMSVLEAFSCGTPVMLRDLDLYHSIIKGYYIAADNYAEMDQKLSALVKNPAQLRDYQQRADQASAEYSEDHLAEIWLKYYSSLLK
>CP035154.1|QAR86549.1|710121_711309_+|glycosyltransferase-family-4-protein
MNIGLFTDTYFPQVSGVATSIKTLRDQLEKQGHQVYIFTTTDPKVDTNVYERNVFRFTSIPFVSFTDRRIAISGFIRATQIAKELNLDIVHTQTEFSLGWMGKFVAKALKIPVIHTYHTMYEDYLHYVANGKLLKPYHVKQMTRAFCYHIDGIVAPSERVQRTIQRYGIQVPTRIIPTGVNLEQYQKDSNPQQCREALGYDAKTPVLLSLSRLAYEKNIQEVIDCFPAILKEVPDAQLLIVGDGPARTSLENQVHDLGLEKHVKFTGEINNDQVYRYYQAADLFVSASDSESQGLTYIEAMASHLKVVAKSGPYTDELLDDPSLGKVFDTEAQLVQAIKRYIEHPDEFNDPRPREKKLYEISADYFGKRIVDYYNSAISAHADLEHGSKKESELE
>CP035154.1|QAR86548.1|709262_710036_+|alpha/beta-hydrolase
MEFILKTGENIYYEDQGEGIPILFLTGFGGNTEIWSGQVNFFLQHGYRVIRLDYLNHGRSDRVDYDLKIGDLADEVLQLVDALEIKEPIGIGNSMGAAVLWNILSIRGWDFVSKAIFVDQSPRMMNDDQWHYGFKNLSEANFEQLMSEPILRPAYRRIEGYVYKNSKAIDSKYPFSQPKNRSLVKGHARKDWRPVLRAATKPVLFILGEKSPFFNPQMGDALKQLNSRIQVEVMPNVGHIPMAEEPAQFNQLVLRFL
>CP035154.1|QAR86547.1|707465_709190_+|phosphoenolpyruvate--protein-phosphotransferase
MTGTLKGIAASDGIAIAKAYLMVDPDLSFEKKTITDVDAEINRLHDALEQSKKELTLIKAKAAENLGAEEAEVFEAHLTILSDPELIGNIEDKIKNDTINAEEATKEVTDNFIAMFEAMTDNAYMQERAADIRDVTKRLMSHLLGVELPNPALIDSEVIIVAHDLTPSDTAQLDRRYVKGFITDIGGRTSHSAIMSRTLEIPAVVGSEKATTSVKQGDMMIVDGLTGDALINPSDDEIKEYEQKSADFKAQKAEWEKLKNERTVSKDGVHFDLAANVGTPDDLQGVLDNGGEAVGLFRSEFLYMNASELPSEDQQFEAYKKVVEGMNGKQVVVRTMDIGGDKDLPYLPLPEEMNPFLGYRAIRISLDRTDLFRTQLRALLRASAYGKLAIMFPMIATVAEFKKARAIYDDERQKMIDAGTKVGEIQVGMMMEIPAAAMIADKLAKYVDFFSIGTNDLIQYSFAADRGNEKVSYLYQPYNPSLLRLIKQTIDASHAEGKWTGMCGEMAGDQIAVPILMGLGLDEFSMSATSILKTRSLMKKLSTDDMKKLAEKAITEAETNEDVIKLVEETVNNK
>CP035154.1|QAR86546.1|707199_707466_+|phosphocarrier-protein-HPr
MEKRDFHVIAETGIHARPATLLVQAASKFNSDIQLTYKDKSVNLKSIMGVMSLGVGQGADVTISADGDDEADAIAALEDTMKKEGLSE
>CP035154.1|QAR86545.1|706868_707057_+|hypothetical-protein
MRDYLKLLNDLKDGVLDELTITAEEFQDFQPVFMDFPERKQLIGEAQRGGTITYRYENNKKQ
>CP035154.1|QAR86544.1|704445_706653_-|ATP-dependent-Clp-protease-ATP-binding-subunit
MLCQNCHKNEATIHLYTNVNGRRTEVNLCQNCYQLLKNQQLNNNNGNGGARMAQDPFGFGNLDDIFRAMQGGNVSRPEDMYGQQVPPTQAGRGGGNNPNGGNGSSLLGQYGLNLTDLAKQGKIDPVIGRDKEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQRIVEGSVPQKLLNKQIIRLDVVSLVQGTGIRGQFEQRMQELMKEVQNNPDLIVFIDEIHEIVGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEEEAIKILKGIQKKYEDYHHVHYTDDAIVAAVKLSKRYIQDRYLPDKAIDLLDEAGSKKNLTINVADPETIQKKIDEAETEKKKALESEDYEKAAYYRDQVSKLEKNKDGATNKEDEPTITAEDMEKIIESKTDIPVGDLQKQEQEQLQNLASNLKAHVIGQDEAVDKISRAIRRNRIGLNGTGRPIGSFLFVGPTGVGKTELAKQLADQLFGSKDAMIRFDMSEYMEPHSISKLIGSPPGYVGYEEAGQLTEQVRRHPYSLILLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGSGDVEADVGFGAAMQGKTHSVLDKLGNYFKPEFLNRFDDIVEFHALTKDNLMQIVDLMIADVNKMLATQGLHVNVTKPVEERLVELGYDPKMGARPLRRVIQEQIEDRIADFYLDHPSEKQLIARIKDDKIEVAPDDKK
>CP035154.1|QAR86543.1|703243_704221_+|GMP-reductase
MKVFDYEDIQLIPAKCVVRSRSECDPTVELGKHTFKLPVVPANMQTIINEEIAEKLAADGYFYIMHRFEPETRLAFVKKMKAKGLISSISVGVKDGEYDFIDELAAKNLVPDYITIDVAHGHAQTVIDMIHYIKEKLPESFVIAGNVGTPEGVRELESAGADATKIGIGPGKVCITKLKTGFGTGGWQLSALRWCAKVARKPLIADGGIRNHGDIAKSIRFGATMVMIGSLFAGHIESPGETKVEDGVTYKEYFGSASQYQKGEAKNVEGKKIWIHQRGHLADTLKAMREDLQSAISYAGGRDLESIRKVDYVIVKNSIFNGDIL
>CP035154.1|QAR86542.1|701885_702137_+|hypothetical-protein
MNEKEFANLCKEKVANYLKEEKGLKVTADDIYIVWLARILQNSKALLSSTFDDGMYFEATYNGDKNQLYLDAYKKEKNIGFDI
>CP035154.1|QAR86551.1|721003_721735_-|hypothetical-protein
MNKIKIPKINYHVDRKSYLPAILAVILTSTIWYFSGHFSSEPFKHNLTVQIIFFLASFMANFITFDQLTNKTNLRLIAPLAVIPVAFFIILLVSKERYVSLLGLLTLVPFVSVFLPFQGKNGVGLISFAFSISVLSPIAFFYIRNAFVSSMFLKTCLLLCLVFLMILFSVFVAHPEQFIYLEIGLLVVITIFGFVLFKQWSAVLYPMIGILGWYLPRVKLPRNFILLVLIILICVTFLFTAGH
>CP035154.1|QAR86552.1|721906_723097_+|methionine-adenosyltransferase
MSERHLFTSESVSEGHPDKIADQISDAILDELLKNDPDARVACETTVTTGLVVVVGEISTTAYIDIQKVVRKTIKDIGYVGGEYGFDGENCAVIVAIDEQSPDIAQGVDDSLETREGHEDRLNRIGAGDQGLMFGYATDETKELMPLPIMLSHHLMQRIAKLRKEQVISYLRPDAKAEVTVEYDDNDQPVRVDTVVLSTQHDPDVTLEQIRKDVIEKVIKEVIPAELLDEKTNFYINPTGRFVIGGPQGDAGLTGRKIIVDTYGGAAHHGGGAFSGKDATKVDRSASYAARYIAKNIVAAGLAKKAEVQIAYAIGVAEPVSVMVDTFGTGKVSEEALTKAVRQIFDLRPAGIIEMLDLKRPIYKQTAAYGHFGRTDVDLPWEKTDKVAELKAFFQK
>CP035154.1|QAR86553.1|723272_724742_+|DHA2-family-efflux-MFS-transporter-permease-subunit
MKKKQTNVALVTVAIFVATFMSAIEGTIVSTAMPTIVGDLHGVNLMNWVISIFLLTNAIFTPIYGKLSDIFGRKRVFIIGIIIFLIGSMLSGLAHSMTTLIIWRALQGIGAGSIMPVSNTIIADIYSLEKRAKVMGLNGSAWGIASIIAPLLGGFIVDNLSWHWIFFINVPIGIITIILIQLYLKEEVSVHRKKIDYWGSVWLMLSLLGLMYGFQLLGESTASKLILGLSFIIFVVAGALFIRQERRAEDPIIFLDLFNDRTFVIQNVATMLVSGLLIGFEVYLPTWTQGILGLPASLAGFAVTPSSVLWIFGSFLAGKMLVKLKANQILRISLTILAIGSFLLAVIPASTPFVAFFFIAAILGVGFGITITSTLVISQQLVSKDRIGVATSFNTLAKTLGQTIMMSVFGIIMNGTINMGIAHHPRINMTMMNQVINPQTAKQLPADLLPTLRDILYSALHNIYICGFILIIVAIVINAFSRPRTQKNK
>CP035154.1|QAR86554.1|724821_725385_-|methyltransferase-domain-containing-protein
MLDNAMQYSHRLLAEVVQPGDHVVDATMGNGHDTFFLANLVQSQGRVFSFDIQAAALSATEARLEKQLPDHQHVQLIQDSHDQLAQYVDTPISGAVFNLGYLPGGNKQIITHSASTIAAVQQCLQLLKVGGRVVLVCYYGHPGGAAELAKLLEFTANLDQHQFTCLRYEFINQVHQPPILLAIERRK
>CP035154.1|QAR86555.1|725377_726013_-|phosphatase-PAP2-family-protein
MRFKKFGWLILNWLPLLGLLTLVISVSNRWNWVHTYDRYLQKIIHGWQSPGLTPLVKIYTQLGNAKPFIFISIVILGMLLWRGYDRLAAFFLANVVLGNAINHLIKLWIQRPRPHFRLITIGGYSFPSGHSVAAMLLFGSLIFITTQTVRSPKWRISWILTCIILMLLLGLSRVYLNVHYPSDVTAGLLLGLVILQTTHWIFYRKKESQHA
>CP035154.1|QAR86556.1|726418_728836_+|leucine--tRNA-ligase
MAYNHKEIEPKWQRYWQKHETFKTVESEQKPKYYALDMFPYPSGQGLHVGHPEGYTATDIMSRMKRMQGYKVLHPMGWDAFGLPAEQYAMKTGNNPKDFTAHNIKNFKRQIQSLGFSYDWSREVNTTDPEYYKWTQWIFEQLYKKGLAYEKETLVNWAPDLMGGTVVANEEVVNGKTERGGFPVYRKPMKQWILKITAYADRLIDDLDLVDWPDSIKEMQKNWIGRSIGASVFFDVEDSDQKIEIFTTRADTLYGATYLVISPEHPLVDQLTTLESKAAVEEYKQTVATKSDLERTDLNKDKTGVFTGSYAVNPVNGKKIPIWIADYVLASYGTGAVMAVPAHDPRDYEFARKFKIDIVPVIGGGNLDEEAYTGDGPHINSGFLDGLNKQEAIDKMLDWLEEHGAGHKKVNYRLRDWVFSRQRYWGEPIPVIHWEDGETTLVPEDELPLRLPATDNIKPSGTGESPLANLEDWLNVVDENGRKGRRETNTMPQWAGSSWYFLRYVDPKNQNKIADEDLLKEWLPVDLYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEPFQKLVNQGMILGSNHEKMSKSKGNVVNPDDIVERFGADTLRLYEMFMGPLTESVAWSEEGLNGSRKWIERVWRLMIDDNNHLRDRITMINDHKLDLIYNQTVKKVTEDYENMRFNTAISQMMVFVNEAYKADALPMVYMEGLVKLLSPIIPHVAEEIWQIMGHDETITYETWPTYDESKLVQDTVQVILQVNGKVRSKVEVEKDLDQAELEKIALADERIQQWTAEKDIKKVIVIPNKIVNIVAK
>CP035154.1|QAR86557.1|729092_730775_+|polysaccharide-biosynthesis-protein
MDKPSEFDTAESQYLGSQPLRENSGNSSSKAKMLEGSAWMTAGSIFSRILGAIYIIPWVIWFGVYSDQANALYTKGYNIYSFFLIAAIAGIPSAISKQVAHYNAINEFALGQRLYKRGLLLSVGTGVVCAAILFFGAPFLNDGDPNVTTVLHALAWAVLVIPTMSLTRGFFQGYQEMGPSAVSQFIEQLARVAYMLVTAYLIMYKNHGDWVYGVAQSTFAAFIGALGGLLVLIGYFVKYRRRLRYLSQHSVNGLAISTTSLYKEIIAQAVPFIIIGSAITIFQLIDQYTFFRIMRSVSDYSATVLNNMFAIFAFNANKLVMIVISLASALAVTSVPILSEAKTRGDRAEISRQVADSILLFAFLMIPSALGMAAVAQPAYTLFYHLSDVGTAILQFNSYVAIVLGLFTVISAVMQGIGENVLAVKYFVVGMIVKFIFQFPMVAIFSAVGSLISTAIGFAVVNWLILRHINREYGLDYDKINGFIGKIITYSFGTFFIAFVVTNGLYLVMNPANKVQALIVILVAATLGGLFYVVCVLKSRLADEIIGGRAAGLRRMLKIK
>CP035154.1|QAR86558.1|730785_731505_+|rRNA-pseudouridine-synthase
MRVDKFLHDMNVGTRSQIRKLIKEKAVFVNDVVAKSGRVKVDPVVDQVRLGEQVITYQQYFYFMMNKPLGVVTATEDRKQKTVMDLFNKVDFRKDLFPVGRLDKDTEGLLLITNNGPLAHQLLAPERHVQKTYEAVVTGQITDPAVKQFADGMVLKDGTQLKPADLTILNYSALDEQTLVHVTLKEGKYHQVRRMFGSLGERVVSLKRISFGPLQLEEGLLPGTYRELNDEEIEKLKTE
>CP035154.1|QAR86559.1|731611_732442_-|NAD(P)H-hydrate-dehydratase
MLKISRQTLKSHWPVRRNQSHKGTYGHLLLIAGNAQYGGAGILAASAAVYAGGGLVTLATAKNNFTAVRATLAEIMLIDFTDFDQLSQSLANATGVVIGPGLGTDSTSLAVLNFTLAHIAEGVPLIIDGSAIDLVAQHDLQVSHHPTIYTPHQMEWQRLSGIKIADQSVGRNQAVVDQLNATVVLKHYHTEIYAPAAPVAQIMAGNPGMATGGSGDSLTGILLALIAQANSVNEGVRLGTFLHSYTADLIYEHEAVVLPHRLIRRLPAVLKQLTQP
>CP035154.1|QAR86560.1|732567_733029_+|universal-stress-protein
MDYKKILFGYDGSPESMAAFNRAVEIAKSNHAKLIIASVMKKQHANTASVSLGFGVIETGIDLQDTLDQWKTTLEKLKQDAQQQGLPAEDIEVVFKQGSPKSMLSYTLPKEYDVDLIVLGATGMGTVAQVILGSTASYVVENAAPDVVIVKNN

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Crispr_ID: CP035154_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

CP035154_4

1471724-1471880

Orphan

Consensus_repeat	Method
ATCTCTTCGTCGCCTAGCTCCTCGACATTACTGTGAC	PILER-CR

2 spacers

The CRISPR arrays of CP035154_4

>merge|CP035154|4|1471724-1471880|PILER-CR
ATCTCTTCGTCGCCTAGCTCCTCGACATTACTGTGACACTCTCAACGGTTCGGATCTTGCCAATCACTCGTCGCCTTGCTCCTCCTTCTTGGAGTCCTATCGCATGGAGCGTCTCTAGCAATCTCTTCGTCGCCTAGCTCCTCGACATTACTGTGAC

>CP035154|4|2|1471724-1471880|PILER-CR
ATCTCTTCGTCGCCTAGCTCCTCGACATTACTGTGAC	ACTCTCAACGGTTCGGATCTTGCCAATCAC
TCGTCGCCTTGCTCCTCCTTCTTGGAGTCCTATCGCA	TGGAGCGTCTCTAGCAATCTCTTCGTCGCCTAGCTC
CTCGACATTACTGTGAC

Protein	Signature genes	Signature genes Name	Protein_function
CP035154.1\|QAR87263.1\|1470071_1470530_+\|flavodoxin	unknown	unknown	gnl\|CDD\|180922
CP035154.1\|QAR87271.1\|1478973_1481247_-\|DNA-helicase-PcrA	unknown	unknown	gnl\|CDD\|273429
CP035154.1\|QAR87260.1\|1467345_1468476_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
CP035154.1\|QAR87273.1\|1482510_1483083_-\|xanthine-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|181705
CP035154.1\|QAR87261.1\|1468556_1469111_-\|DUF402-domain-containing-protein	unknown	unknown	gnl\|CDD\|184219
CP035154.1\|QAR87268.1\|1475946_1477407_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	unknown	unknown	gnl\|CDD\|234572
CP035154.1\|QAR87262.1\|1469203_1470019_-\|recombination-regulator-RecX	unknown	unknown	gnl\|CDD\|237619
CP035154.1\|QAR87275.1\|1483846_1484455_-\|ECF-transporter-S-component	unknown	unknown	gnl\|CDD\|227029
CP035154.1\|QAR87258.1\|1465230_1466799_-\|peptide-chain-release-factor-3	unknown	unknown	gnl\|CDD\|179105
CP035154.1\|QAR87256.1\|1461948_1462794_-\|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl\|CDD\|376667
CP035154.1\|QAR87255.1\|1461585_1461948_-\|DUF1634-domain-containing-protein	unknown	unknown	gnl\|CDD\|377927
CP035154.1\|QAR87266.1\|1473496_1474492_-\|diacylglycerol-kinase	unknown	unknown	gnl\|CDD\|237282
CP035154.1\|QAR87270.1\|1477740_1478898_-\|CamS-family-sex-pheromone-protein	unknown	unknown	gnl\|CDD\|377863
CP035154.1\|QAR87272.1\|1481337_1482477_-\|ATP-grasp-domain-containing-protein	unknown	unknown	gnl\|CDD\|235674
CP035154.1\|QAR87269.1\|1477406_1477721_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	unknown	unknown	gnl\|CDD\|178810
CP035154.1\|QAR87257.1\|1462958_1465127_-\|LTA-synthase-family-protein	unknown	unknown	gnl\|CDD\|224287
CP035154.1\|QAR87264.1\|1470732_1471359_-\|N-acetyltransferase	unknown	unknown	gnl\|CDD\|225695
CP035154.1\|QAR87274.1\|1483104_1483746_-\|N-acetylmuramidase	unknown	unknown	gnl\|CDD\|224619
CP035154.1\|QAR87267.1\|1474519_1475947_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	unknown	unknown	gnl\|CDD\|235489
CP035154.1\|QAR87259.1\|1466865_1467270_-\|glycerol-3-phosphate-cytidylyltransferase	unknown	unknown	gnl\|CDD\|173922

Protein	Function_ID	Function_description	E-value
CP035154.1\|QAR87263.1\|1470071_1470530_+\|flavodoxin	gnl\|CDD\|180922	PRK07308, PRK07308, flavodoxin; Validated.	6.43634e-46
CP035154.1\|QAR87271.1\|1478973_1481247_-\|DNA-helicase-PcrA	gnl\|CDD\|273429	TIGR01073, ATP-dependent_DNA_helicase_PcrA, ATP-dependent DNA helicase PcrA. Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair].	0
CP035154.1\|QAR87260.1\|1467345_1468476_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	7.75449e-60
CP035154.1\|QAR87273.1\|1482510_1483083_-\|xanthine-phosphoribosyltransferase	gnl\|CDD\|181705	PRK09219, PRK09219, xanthine phosphoribosyltransferase; Validated.	9.2203e-114
CP035154.1\|QAR87261.1\|1468556_1469111_-\|DUF402-domain-containing-protein	gnl\|CDD\|184219	PRK13662, PRK13662, hypothetical protein; Provisional.	3.25922e-114
CP035154.1\|QAR87268.1\|1475946_1477407_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA	gnl\|CDD\|234572	PRK00012, gatA, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA.	0
CP035154.1\|QAR87262.1\|1469203_1470019_-\|recombination-regulator-RecX	gnl\|CDD\|237619	PRK14135, recX, recombination regulator RecX; Provisional.	2.96539e-92
CP035154.1\|QAR87275.1\|1483846_1484455_-\|ECF-transporter-S-component	gnl\|CDD\|227029	COG4684, COG4684, Predicted membrane protein [Function unknown].	1.81574e-13
CP035154.1\|QAR87258.1\|1465230_1466799_-\|peptide-chain-release-factor-3	gnl\|CDD\|179105	PRK00741, prfC, peptide chain release factor 3; Provisional.	0
CP035154.1\|QAR87256.1\|1461948_1462794_-\|sulfite-exporter-TauE/SafE-family-protein	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	6.54327e-35
CP035154.1\|QAR87255.1\|1461585_1461948_-\|DUF1634-domain-containing-protein	gnl\|CDD\|377927	pfam07843, DUF1634, Protein of unknown function (DUF1634). This family contains many hypothetical bacterial and archaeal proteins. A few members of this family are annotated as being putative transmembrane proteins, and the region in question in fact contains many hydrophobic residues.	9.2811e-29
CP035154.1\|QAR87266.1\|1473496_1474492_-\|diacylglycerol-kinase	gnl\|CDD\|237282	PRK13055, PRK13055, putative lipid kinase; Reviewed.	0
CP035154.1\|QAR87270.1\|1477740_1478898_-\|CamS-family-sex-pheromone-protein	gnl\|CDD\|377863	pfam07537, CamS, CamS sex pheromone cAM373 precursor. This family includes CamS, from which Staphylococcus aureus sex pheromone staph-cAM373 is processed.	8.56407e-152
CP035154.1\|QAR87272.1\|1481337_1482477_-\|ATP-grasp-domain-containing-protein	gnl\|CDD\|235674	PRK06019, PRK06019, phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed.	1.77244e-57
CP035154.1\|QAR87269.1\|1477406_1477721_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC	gnl\|CDD\|178810	PRK00034, gatC, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC.	9.55701e-35
CP035154.1\|QAR87257.1\|1462958_1465127_-\|LTA-synthase-family-protein	gnl\|CDD\|224287	COG1368, MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane].	1.53318e-158
CP035154.1\|QAR87264.1\|1470732_1471359_-\|N-acetyltransferase	gnl\|CDD\|225695	COG3153, COG3153, Predicted acetyltransferase [General function prediction only].	2.33179e-25
CP035154.1\|QAR87274.1\|1483104_1483746_-\|N-acetylmuramidase	gnl\|CDD\|224619	COG1705, FlgJ, Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion].	6.48525e-64
CP035154.1\|QAR87267.1\|1474519_1475947_-\|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB	gnl\|CDD\|235489	PRK05477, gatB, Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB.	0
CP035154.1\|QAR87259.1\|1466865_1467270_-\|glycerol-3-phosphate-cytidylyltransferase	gnl\|CDD\|173922	cd02171, G3P_Cytidylyltransferase, glycerol-3-phosphate cytidylyltransferase. Glycerol-3-phosphate cytidylyltransferase,(CDP-glycerol pyrophosphorylase). Glycerol-3-phosphate cytidyltransferase acts in pathways of teichoic acid biosynthesis. Teichoic acids are substituted polymers, linked by phosphodiester bonds, of glycerol, ribitol, etc. An example is poly(glycerol phosphate), the major teichoic acid of the Bacillus subtilis cell wall. Most, but not all, species encoding proteins in this family are Gram-positive bacteria. A closely related protein assigned a different function experimentally is a human ethanolamine-phosphate cytidylyltransferase.	4.28211e-70

>CP035154.1|QAR87264.1|1470732_1471359_-|N-acetyltransferase
MEKDYLIRLEKPADYRKTEAMVREAFWNVYRPGCYEHYVLHVLRKSSEFVPQLNLVMEKDHQIIGQICFVKAKLVDKNGNEVPVLTFGPLSIAPAYQRKGYGKKLLDYGIAQARKWGASALCIEGNLAFYKHAGFEVAATKGIRYAGEPENGELPYFLAKELREGFFEQVQGALYYTPSAYYVSESDVNKFDQQFPLKEKRVLPGQLA
>CP035154.1|QAR87263.1|1470071_1470530_+|flavodoxin
MPTAKVVFATITGNNEDCADIITEALEDLGVEVDETEISQTDAAELKDYDINVIVPYTYDEGALPEEGLDFYDDLADLDLSGKIYGVAGSGDTFYEEFYCVAVDKFSEALTKANATKGTADLKINLAPESQEDLDHLDQFAQDLVDAYNAQN
>CP035154.1|QAR87262.1|1469203_1470019_-|recombination-regulator-RecX
MININSEETKKITKITAQKRAGRYNVFLDGEYAFPISEETFIHFRLGKGMAVNGTLLKEIGEYETNAEAYNIALTYITGQLRTENEVRQKLRQQDYEESVIEAVIAKLADLNLLDDREYAKSYVRTMMRTGDKGPRYLINHLRQKGVLENDLQAGLQLFSDTKQVALATRVGQKLQKRHQAQALRQQQLKIQQNLMQKGFTSEIIEKALAEIEFTVDSDAEYEKLRKLGERLLRRYQGQPEYQRTTKIKRSLYQKGFEMELIERFLNENDF
>CP035154.1|QAR87261.1|1468556_1469111_-|DUF402-domain-containing-protein
MSQYSDGPKEGEYIAIKSYKHDGSLHRTWRETMVLKNSQDEFIGCNDHTVVIEDNDRRWVTREPALVYFNKHTWFNVVAMIRDNGVSYYCNIASPYVLDREALKYIDYDLDVKVFPNGERRLLDTDEFEQFSRQWHYSADTIQILLDSVRELTDWINKKRGPFSVEFINIWYKRYLNIAERNTR
>CP035154.1|QAR87260.1|1467345_1468476_-|AI-2E-family-transporter
MFEKFRKTPLMYWSLELLIIATLLWVCTKIDFLFSPIGTFISTVFMPLILATFLYYMLHPLVKLLMKVHYKKFRISRTWAVVLVFVGFLLLIAWGISSFLPSLIDQISQMLGNLPMIAKKLQVAIPQLVDHSWLRKVDFDPYLKNLNSEIGQYAEQFLANMTNSIGNIIAALTNITVIVITVPIILFYMLKDGYKLIPTISRIVPEHNRKSVLDLFYSMSDTLSSYISGQVIECIFVGTFTVIGYMIIHQPYGLVLGVIAGICNIIPYVGPYFGIFPSLLVAIAQSPEQVISVIIVVLIVQQVDGNLIYPNVIGKSLQIHPLTIIILLLVAGKLAGILGMILAVPTYAIVKVLINFIHHIWVLDRDKIEEKVKPEK
>CP035154.1|QAR87259.1|1466865_1467270_-|glycerol-3-phosphate-cytidylyltransferase
MTRVITYGTFDLLHKGHVRLLKRARELGDHLTVCLSTDEFNAVKGKKAYTPYEDRKYILEAIKYVDEVIPERGWDQKINDVKENDIDIFVMGDDWKGQFDFLKDYCKVIYLPRTEGISTTKIKRDLGLGDYKKD
>CP035154.1|QAR87258.1|1465230_1466799_-|peptide-chain-release-factor-3
MNQAELKAAVDKRRTFAIISHPDAGKTTITEQLLLFGGVVREAGTVKARKTGNYAKSDWMEIEKKRGISVTSSVMQFDYAGKRINILDTPGHEDFSEDTYRTLMAVDSAVMVIDSAKGIEPQTKKLFQICKMRGIPIFTFMNKLDRDGREPLDLVNELEEVLGIDAYPMNWPIGMGKGLAGLYDIYNNRIELHTDEPEYLALDSNGELKEPNPIEEESVFQDAMMEVDLMKEAGNQFDEAKIAKGELTPVFFGSALTNFGVKTFLDAYLQFAPAPSAHKVADGEQIQPTDEEFSGFVFKIQANMNPNHRDRIAFLRICSGEFDRGMDVTLKRTGKTLRLSNSTQFMADARENVERAVAGDIIGLYDTGNFQIGDTIYAGKQPVQFEKLPQFTPELFMGVSAKNVMKQKSFHKGIQQLVQEGAVQLYTNYTTGDYILGAVGQLQFEVFQFRMQNEYNSEVVMQPMGKKIARWINPEQLDEKMSSSRNLLVKDRAGQPLFLFENQFAERWFKGKYPDVELTAKL
>CP035154.1|QAR87257.1|1462958_1465127_-|LTA-synthase-family-protein
MNRLWGKFRRGLNTKFGFFMLITGLFWLKSYIAYQTKFTLGVQGGMQELILAISPLGFAILLFGIGLYIRGKWAYWYMIVMDAILSTWLFANILYYREFSDFITFNLIKGSGAASDNLGKSLMGILRPTDFLVFVDVIFVIAILAFGFAKIDQQRFKLVNSLAVTILSIGVLAANLALAYSNRSGLLTRTFDNNYIVKYLGLQSFTLYDGVKTVQNSNKKKEAKSSQLKPINEFLKKNNVPANIEYKGVAKGKNVIIIHLESLQQFVINQKWKGKEITPNINKFYNDKNTLAYDNFFNQVGQGKTADAEMMLENSLFGLPEGSAMVTDGTTNTFQSMPAIMDQHGYTTAAFHGDVASFWNRDNAYKSFGYQYFFSKQYYSLKKGYVSGYGMKDKLFLQQSAKFLEELPQPFYAKLITVSNHYPYGIEKKNVSIDPWETGDSTVDPYVQTAHYLDQAVGELISYLKKTGLYDKSLIMMYGDHYGISNNHKPAIAKILGLKGVTNYDLAMFQKVPFMIHAPGLKGGVNHNYSGEIDVMPTLLNLLGIDTPGAYQFGHDINSKQYNQIVAFRNGDFVSKKYTKYGGDLYYTATGEQITDETASQKREVKQIQQYVNNELNYSDRIINGDLLRFADLDWFKKVNKADYSYTKKTALKNLKKAQKSKTSLLEQNHGRSTVDDYVTDAPELPENEDKAASSSSSSNSSSEDSSHSGSSSADPATQEDK
>CP035154.1|QAR87256.1|1461948_1462794_-|sulfite-exporter-TauE/SafE-family-protein
MASHLIILLLVGLLAGVFGAILGIGGGMIITPVLTIGMGLDIKYAIGASIIAVIATSSGATIAYLKDEMLNLRVAMFLEIATTVGAIVGAIMTGIFNSTVLYVLFGSFLVFSSWNMYRKLRQGGSEEGSAKNDRLANRLNLSGSYYDKALQKQINYQVENVPGGSAVMFGAGLASGLLGIGSGAFKVMAMDNIMKMPLKPSSATSNLMMGVTAAASAMVYFFNGSIHADIAGPLAIGILFGAQLGSRIMQRLRPRWIRLIFIPVLLYMGLQMVLKGFGVNF
>CP035154.1|QAR87255.1|1461585_1461948_-|DUF1634-domain-containing-protein
MNAKQKEMNHVELLIGRILQVGVYISAIVIICGIGLWLVKNGSGYAGALPTRLGVIFQGAMQLKPYAVLMLGIFLLILTPVLRVVVSIYAFAKEGDRLYVAITTIVLIILIIGMTIGYQG
>CP035154.1|QAR87266.1|1473496_1474492_-|diacylglycerol-kinase
MRKRARIIYNPTSGREMIKQHLVEILAVFEKAGYETSAFATTPEPNSAKNEAHRAAKDGFDLVVAAGGDGTINEVVNGIAPLHRRPKLAIIPAGTTNDYARALRIPREDPVAAAKVVLQNQRMKMDIGKAGDNYFINIAAGGLLTELTYDVPSNLKSIFGYLAYIVKGAEMLPRVKPVEMDIEYDGEHFHGQASMFFLALTNSIGGFEQIVPDASLDDGKFTMIIVKSSSLPDLLHLMVKALNGKHVDDPRIIYRKARKVVVNPVNERVMVNLDGEYGGDAPMVFKNLKRHIDMFTNLDSVPVSEPEDDEYRQVEEQFVAEVQNLSQDDQE
>CP035154.1|QAR87267.1|1474519_1475947_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatB
MNFKTTIGLEVHIELKTNSKIFSPSPVEFGDQPNENTNVIDWGYPGVLPQTNKGVVEAGMMAAKALHANIARTQHFDRKNYFYPDNPKAYQITQADTPIGTDGWIEIEVDGKKKKVGIAEMHIEEDAGKNTHNPNGYSYVDLNRQGTPLIEIVSKPDIESPDEAYAYLEALRQRIQFTGISDVKMEEGSMRVDVNISIRPEGSNTYGTKAELKNINSFNFVRKGLAYEEKRQQKLLLSGGEVRPETRRYDEATGQTILMRVKEGADDYRYFPEPDLPSITISDEWIKAVEDKMPEMPGKRRARYVNELGLSDYDAMVLTQTKEMSDFFEAAIAFDADPKLVANYLMGDVNAYLNDQKVDLQDTKITPEHLASMVKMISDETISSKIAKKVFKAITKGEEPVSWVKERGLVQLSDPAVLKPIITQVVDDNEQSVIDFKNGKDRAVGFLVGQIMKQTKGQANPKVVNQILMQELNAR
>CP035154.1|QAR87268.1|1475946_1477407_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatA
MKFFDITVTELHQKLVDRELTVTELVSQTLDQIEADQAVLNDFVTINRDEALKQAQAIDEKGVDPDNLWAGIPIAVKDNIVTKGLKTTASSKMLSNFTPIYDATVIERLKANDVIVIGKTNLDEFAMGGSTETSFYGTTRNPWDHTKVPGGSSGGSATTVAAGNSIAALGSDTGGSIRQPASYTGIVGVKPTYGRISRYGLIAFGSSLDQIGPMTRTVKDNAALLNIIAGMDERDLTSSDKEVPDFTAKIGQDIKGMKIALPKEYLGKGINADVKATIKQAVQTLTDLGATVEEVSLPRSNYGVAAYYIIGSSEASSNLQRFDGIRYGYRADDVKNLEDVYVKSRSEGFGDEVKRRIMLGTYALSAGSYDAFFKKAAQVRTLIIDDFNKVFENYDLIIGPTAPTPAYKIGAEVDDPTTMYMNDVLTIPVNLAGLPAMSLPAGFSEGMPVGLQMIAKPFDEQTMYQAGAAFEAATNFYQKHPETEDK
>CP035154.1|QAR87269.1|1477406_1477721_-|Asp-tRNA(Asn)/Glu-tRNA(Gln)-amidotransferase-subunit-GatC
MTVENNITKNDVAHVATLAKLKLDDAQLEKFTNQFEDIIDLVEQLNEVDTTDVEPTFNVTDQLNRMREDQAVRSGDKEALLNNAPDTEDGFIRVPAILDESEEA
>CP035154.1|QAR87270.1|1477740_1478898_-|CamS-family-sex-pheromone-protein
MKVTKKISLLVATLLLGVGLSACGGLNNSSMSSATNNVTGEKNKKTTYQTTGSSSGQYAGVIKNGKYVVSKSRGLTADQNGNVNNTKSFETGLQDVSKEVFAPSKYVFQEGQYLSSDTVQSWLDRKSKKNPDGLNPKDNGSKDPDKRNPIYLQALEEQDYMQKSGNSLKLKGVTIGLAMNTVDYYQKKQYGAEYETKISDAEIKEQSTRIAKEVLQRLRKKDEFKNIPIVIAVYKQASNDSLTGGTFIRYSNNQGNQLASWKNLDYKNVVYPIGDNESTPNSNDSTAFDNFKTQVESFFPNLSGITAKARYKGDSMQGMSVTITTQFYSETEINSFTQFVSTQAEKYLPSGVNIDITIRSSDDVQSFLSRSSKDKTFSSHVFTSY
>CP035154.1|QAR87271.1|1478973_1481247_-|DNA-helicase-PcrA
MPENDLLKGLNDMQQQAVQTTEGPLLIMAGAGSGKTRVLTHRVAYLIEEKDVNPWNILAITFTNKAAREMRERVANLLGEVASEIWVSTFHALCVRILRRDIEQIGYNRAFSIADPSEQRTLIKHVLADLNYDPKVYDPRSVLGKISNAKNDLMTPADYQENASNPHDEAVGKIYDEYQRRLKANQALDFDDLIMQTIRLFEQSPETLQFYQNKFHYIHVDEYQDTNQAQYQLVTMLAKGFRNLCVVGDSDQSIYGWRGADMQNILNFESYYPDAHTVMLEQNYRSTQNILNAANDVIANNVERKPKQLWTDNAEGAKISYYRGQTGNDEVHFIVQQIRKQIEENNFDYGDFAILYRTNAQSRLIEDTFMKANIPYTMVGGHKFYDRKEIRDVLSYLTLIANEEDSMSFERVINEPKRGIGATSMAKLQAFADENSWSLLQAARNVQIANGIARRTRNAIEDFAKTIDALRKSAEFLSITELTETLLDKTGYRAALEQTRTMEAEARLENINEFLTVTKQFDEQNDAEGTEVADENGDNVRLVDFLADLALVSDQDDVEEEPSAVTLMTLHAAKGLEFPVVFLVGMEEGVFPLSRAATDPDELEEERRLAYVGITRAQKKLYLTNAYSRMLYGRTQNNPASRFIGEISAEYLQDENEQVQGFSSSSRNKYPFDRERNARATASVYGTQRAKVSTNQGTGAEKVSWAAGDKVQHKAWGVGTVVKVSGTGEDVELDIAFKDQGIKRLLAAFAPIKRVTD
>CP035154.1|QAR87272.1|1481337_1482477_-|ATP-grasp-domain-containing-protein
MENEVITSKKIIYPGDMIGIIGEGRSSVQLVTTAKSMGFKVSVYVTSEQNEVVHYADKSFVGSLNDGEKLQRFAERCKIVMYESEMVDIKIIKYLQQFVSIPQGTQLLELNQDRIIEKATMEQLGIKTAPYVTIVDLDDLYDSVNEIGYPGILQPILKDPLNEQSLLLESEIDVPKAAPLLERGTYLLQSWPDTGREVALSVVKGQNHRQKMFPMVENIYQNHHLKETRVPVDIDPRIQNNLLEQATKIANSIEYVGVFSIVFYVQDGEIYLKRLIPGIHRSQNIFNLASNTTVYEETLRALSGMVISDIRLQVPTIMLNVAEPQMQKIKTQWLIKDNWHFHFYPQVSEHKDENHVGYVLADGDNVKQIQEQIDNTDVW
>CP035154.1|QAR87273.1|1482510_1483083_-|xanthine-phosphoribosyltransferase
MKLLEDKIRSEGIVLPHNVLKVDGFLNHQVDPQLMFEIGKEFARLFKDQKVTKILTVESSGIAPAVMTGLAMDVPVIFARKHKSLTLKDDLYTASVYSYTKQTSNQISISKRFIDSNDRVLIIDDFLANGQAVSGLFDIADAAKIDVVGVGIVIEKTFQKGSQIIKDRNVQLESLAKIKALTDDGQVEFE
>CP035154.1|QAR87274.1|1483104_1483746_-|N-acetylmuramidase
MAKKKRRRKNNFFYQQGQLKVSSIIGLLLVVCLVVELGMKLRTEATQVTDNLTTTSATAQRHQQFIKTIAPYAQQMQRQYGILPSITMAQAILESDWGQSTLSKKFNNYYGIKGDSDQNSRYFKTQEFVNGKWVTVAARFKVYSSWQESMRDHSLLLVNGTNWNPRQYQAVITASDYKQAAQALYDAQYATDPDYPAKLINLIQKYNLNQYDK
>CP035154.1|QAR87275.1|1483846_1484455_-|ECF-transporter-S-component
MQQANYARKISILALFAAIIIIQNYVPLIGYIPVGPLEITTIHITVIVAAILLGPVDGGIIGGIWGLVDWLRAITVTSSALGNVVMVNPLISIVPRILIGVITGWLVNWLIKTRVPQQATFLIGAIVGSLVNTVLVLSLIYVFYHNGSQVYTALNLKELMPYLLTVAGMHGIPEAIAAGIIAPLLATPLLKFSKIGQQRFKQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP035154_1	1.22\|55038\|22\|CP035154\|CRT	55038-55059	22	CP035154.1	52704-52725	1	0.955
CP035154_1	1.25\|55206\|28\|CP035154\|CRT	55206-55233	28	CP035154.1	52398-52425	1	0.964
CP035154_1	1.22\|55038\|22\|CP035154\|CRT	55038-55059	22	CP035154.1	52182-52203	2	0.909

1. spacer 1.22|55038|22|CP035154|CRT matches to position: 52704-52725, mismatch: 1, identity: 0.955

tggttccgaatcaatctcgact	CRISPR spacer
tggttccgaatcactctcgact	Protospacer
************* ********

2. spacer 1.25|55206|28|CP035154|CRT matches to position: 52398-52425, mismatch: 1, identity: 0.964

tggttcggattcgatttctaagtcaact	CRISPR spacer
tggttccgattcgatttctaagtcaact	Protospacer
****** *********************

3. spacer 1.22|55038|22|CP035154|CRT matches to position: 52182-52203, mismatch: 2, identity: 0.909

tggttccgaatcaatctcgact	CRISPR spacer
tggttccgaatcgctctcgact	Protospacer
************. ********

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP035154_1	1.22\|55038\|22\|CP035154\|CRT	55038-55059	22	NZ_CP042332	Bosea sp. F3-2 plasmid pB32-1, complete sequence	175004-175025	1	0.955
CP035154_1	1.23\|55092\|22\|CP035154\|CRT	55092-55113	22	NZ_CP039693	Agrobacterium larrymoorei strain CFBP5473 plasmid pAlCFBP5473, complete sequence	207424-207445	2	0.909
CP035154_1	1.24\|55146\|28\|CP035154\|CRT	55146-55173	28	NZ_CP042332	Bosea sp. F3-2 plasmid pB32-1, complete sequence	174998-175025	4	0.857
CP035154_2	2.1\|473035\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473035-473064	30	NZ_CP046917	Paraburkholderia sp. DHF22 plasmid p1, complete sequence	48251-48280	5	0.833
CP035154_2	2.16\|474025\|30\|CP035154\|CRISPRCasFinder,CRT	474025-474054	30	MT074141	Bacteroides phage DAC22, complete genome	49789-49818	5	0.833
CP035154_2	2.16\|474025\|30\|CP035154\|CRISPRCasFinder,CRT	474025-474054	30	MT074139	Bacteroides phage DAC19, complete genome	49701-49730	5	0.833
CP035154_2	2.16\|474025\|30\|CP035154\|CRISPRCasFinder,CRT	474025-474054	30	MT074140	Bacteroides phage DAC20, complete genome	49701-49730	5	0.833
CP035154_2	2.1\|473035\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473035-473064	30	NZ_CP049244	Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence	1091638-1091667	6	0.8
CP035154_2	2.3\|473167\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473167-473196	30	NC_008759	Polaromonas naphthalenivorans CJ2 plasmid pPNAP03, complete sequence	141902-141931	6	0.8
CP035154_2	2.14\|473893\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473893-473922	30	NZ_CP049158	Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence	1450106-1450135	6	0.8
CP035154_2	2.14\|473893\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473893-473922	30	NZ_CP049318	Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence	1454774-1454803	6	0.8
CP035154_4	4.1\|1471761\|30\|CP035154\|PILER-CR	1471761-1471790	30	NC_031280	Acinetobacter phage vB_AbaM_phiAbaA1, complete genome	47055-47084	6	0.8
CP035154_1	1.20\|54924\|28\|CP035154\|CRT	54924-54951	28	NZ_CP009146	Sinorhizobium meliloti strain RMO17 plasmid pSymB, complete sequence	1070699-1070726	7	0.75
CP035154_1	1.20\|54924\|28\|CP035154\|CRT	54924-54951	28	NZ_CP021831	Sinorhizobium meliloti strain HM006 plasmid psymB, complete sequence	1322546-1322573	7	0.75
CP035154_2	2.2\|473101\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473101-473130	30	NZ_CP017105	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence	1081212-1081241	7	0.767
CP035154_2	2.2\|473101\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473101-473130	30	CP006880	Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence	1237406-1237435	7	0.767
CP035154_2	2.8\|473497\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473497-473526	30	NZ_CP015231	Epibacterium mobile F1926 plasmid unnamed1, complete sequence	124022-124051	7	0.767
CP035154_2	2.10\|473629\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473629-473658	30	LR595885	Escherichia virus P2_4E6b genome assembly, chromosome: 1	30173-30202	7	0.767
CP035154_2	2.16\|474025\|30\|CP035154\|CRISPRCasFinder,CRT	474025-474054	30	AP014207	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C8-MedDCM-OCT-S26-C6, * SEQUENCING IN PROGRESS *	29042-29071	7	0.767
CP035154_2	2.17\|474091\|30\|CP035154\|CRISPRCasFinder,CRT	474091-474120	30	NC_019699	Chroococcidiopsis thermalis PCC 7203 plasmid pCHRO.01, complete sequence	74568-74597	7	0.767
CP035154_1	1.27\|55320\|28\|CP035154\|CRT	55320-55347	28	NZ_CP034087	Methylocystis rosea strain GW6 plasmid pGW6_1, complete sequence	108302-108329	8	0.714
CP035154_2	2.8\|473497\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473497-473526	30	NZ_CP022035	Salmonella enterica subsp. enterica serovar Onderstepoort str. SA20060086 plasmid punamed2, complete sequence	15877-15906	8	0.733
CP035154_2	2.8\|473497\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473497-473526	30	NZ_CP045959	Salmonella enterica subsp. enterica serovar Birkenhead strain AUSMDU00010532 plasmid pAUSMDU00010532_01, complete sequence	158172-158201	8	0.733
CP035154_2	2.8\|473497\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473497-473526	30	NC_019342	Salmonella sp. 14 plasmid p14-120, complete sequence	26873-26902	8	0.733
CP035154_2	2.9\|473563\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473563-473592	30	NZ_CP033050	Virgibacillus halodenitrificans strain Bac324 plasmid unnamed, complete sequence	65273-65302	8	0.733
CP035154_2	2.10\|473629\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473629-473658	30	MN694397	Marine virus AFVG_250M51, complete genome	16603-16632	8	0.733
CP035154_2	2.2\|473101\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473101-473130	30	NZ_CP032695	Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence	1469007-1469036	9	0.7
CP035154_2	2.2\|473101\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473101-473130	30	NZ_CP041042	Paracoccus sp. AK26 plasmid pAK4, complete sequence	67765-67794	9	0.7
CP035154_2	2.5\|473299\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473299-473328	30	NZ_LR214939	Mycoplasma salivarium strain NCTC10113 plasmid 2	695653-695682	9	0.7
CP035154_2	2.9\|473563\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473563-473592	30	NZ_CP024587	Roseomonas sp. FDAARGOS_362 plasmid unnamed3, complete sequence	60901-60930	9	0.7
CP035154_2	2.13\|473827\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473827-473856	30	MN693447	Marine virus AFVG_25M466, complete genome	14328-14357	10	0.667
CP035154_2	2.13\|473827\|30\|CP035154\|PILER-CR,CRISPRCasFinder,CRT	473827-473856	30	MN693479	Marine virus AFVG_25M465, complete genome	19782-19811	10	0.667

1. spacer 1.22|55038|22|CP035154|CRT matches to NZ_CP042332 (Bosea sp. F3-2 plasmid pB32-1, complete sequence) position: , mismatch: 1, identity: 0.955

tggttccgaatcaatctcgact	CRISPR spacer
tggttccggatcaatctcgact	Protospacer
********.*************

2. spacer 1.23|55092|22|CP035154|CRT matches to NZ_CP039693 (Agrobacterium larrymoorei strain CFBP5473 plasmid pAlCFBP5473, complete sequence) position: , mismatch: 2, identity: 0.909

gggctcggattcaaactccggt	CRISPR spacer
gggctcggtttcaaactccggg	Protospacer
******** ************

3. spacer 1.24|55146|28|CP035154|CRT matches to NZ_CP042332 (Bosea sp. F3-2 plasmid pB32-1, complete sequence) position: , mismatch: 4, identity: 0.857

tggttccgaatcaatctcgacctctagc	CRISPR spacer
tggttccggatcaatctcgacttcgatc	Protospacer
********.************.** * *

4. spacer 2.1|473035|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP046917 (Paraburkholderia sp. DHF22 plasmid p1, complete sequence) position: , mismatch: 5, identity: 0.833

aacaatgt--tcggtaccgatgcggttcgtgc	CRISPR spacer
--cgatgtcctcggtaccgttgcggttcgtgt	Protospacer
  *.****  ********* ***********.

5. spacer 2.16|474025|30|CP035154|CRISPRCasFinder,CRT matches to MT074141 (Bacteroides phage DAC22, complete genome) position: , mismatch: 5, identity: 0.833

atttatcataattatatccactacttaaat--	CRISPR spacer
ttttatcataattatatccaata--taacttt	Protospacer
 ******************* **  *** *

6. spacer 2.16|474025|30|CP035154|CRISPRCasFinder,CRT matches to MT074139 (Bacteroides phage DAC19, complete genome) position: , mismatch: 5, identity: 0.833

atttatcataattatatccactacttaaat--	CRISPR spacer
ttttatcataattatatccaata--taacttt	Protospacer
 ******************* **  *** *

7. spacer 2.16|474025|30|CP035154|CRISPRCasFinder,CRT matches to MT074140 (Bacteroides phage DAC20, complete genome) position: , mismatch: 5, identity: 0.833

atttatcataattatatccactacttaaat--	CRISPR spacer
ttttatcataattatatccaata--taacttt	Protospacer
 ******************* **  *** *

8. spacer 2.1|473035|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049244 (Rhizobium pseudoryzae strain DSM 19479 plasmid unnamed3, complete sequence) position: , mismatch: 6, identity: 0.8

aacaatgttcggtaccgatgcggttcgtgc	CRISPR spacer
cagaatgttcggtaacgatgcggtgcgatc	Protospacer
 * *********** ********* **  *

9. spacer 2.3|473167|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NC_008759 (Polaromonas naphthalenivorans CJ2 plasmid pPNAP03, complete sequence) position: , mismatch: 6, identity: 0.8

accaagccataccgcagtaatgaaggacgc	CRISPR spacer
gtcaccccataccgctggaatgaaggacgc	Protospacer
..**  ********* * ************

10. spacer 2.14|473893|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049158 (Caballeronia sp. SBC1 plasmid pSBC1_2, complete sequence) position: , mismatch: 6, identity: 0.8

gataggcttggaaatgatagataacaacat	CRISPR spacer
ggcaggctttgaaatgacagataacaccgt	Protospacer
*..****** *******.******** *.*

11. spacer 2.14|473893|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP049318 (Caballeronia sp. SBC2 plasmid pSBC2-2, complete sequence) position: , mismatch: 6, identity: 0.8

gataggcttggaaatgatagataacaacat	CRISPR spacer
ggcaggctttgaaatgacagataacaccgt	Protospacer
*..****** *******.******** *.*

12. spacer 4.1|1471761|30|CP035154|PILER-CR matches to NC_031280 (Acinetobacter phage vB_AbaM_phiAbaA1, complete genome) position: , mismatch: 6, identity: 0.8

actctcaacggttcggatcttgccaatcac	CRISPR spacer
attatcaacggttcagatcgtgccaatgat	Protospacer
*.* **********.**** ******* *.

13. spacer 1.20|54924|28|CP035154|CRT matches to NZ_CP009146 (Sinorhizobium meliloti strain RMO17 plasmid pSymB, complete sequence) position: , mismatch: 7, identity: 0.75

cggttcggactcgctttcgaagtcagct	CRISPR spacer
gtcgtcgaactcgctctcgaagtcagca	Protospacer
    ***.*******.***********

14. spacer 1.20|54924|28|CP035154|CRT matches to NZ_CP021831 (Sinorhizobium meliloti strain HM006 plasmid psymB, complete sequence) position: , mismatch: 7, identity: 0.75

cggttcggactcgctttcgaagtcagct	CRISPR spacer
gtcgtcgaactcgctctcgaagtcagca	Protospacer
    ***.*******.***********

15. spacer 2.2|473101|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP017105 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence) position: , mismatch: 7, identity: 0.767

gaagcggacattgcttcggcaaaggcggaa	CRISPR spacer
accggcgacattgctgcggcaaaggcggta	Protospacer
.  *  ********* ************ *

16. spacer 2.2|473101|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to CP006880 (Rhizobium gallicum bv. gallicum R602 plasmid pRgalR602c, complete sequence) position: , mismatch: 7, identity: 0.767

gaagcggacattgcttcggcaaaggcggaa	CRISPR spacer
accggcgacattgctgcggcaaaggcggta	Protospacer
.  *  ********* ************ *

17. spacer 2.8|473497|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP015231 (Epibacterium mobile F1926 plasmid unnamed1, complete sequence) position: , mismatch: 7, identity: 0.767

acgtagtcggcattattaatacggtattga	CRISPR spacer
gggtgagcggcattattgatacggtgttga	Protospacer
. **.. **********.*******.****

18. spacer 2.10|473629|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to LR595885 (Escherichia virus P2_4E6b genome assembly, chromosome: 1) position: , mismatch: 7, identity: 0.767

aagattgattatgcaagaatgactgaaaaa	CRISPR spacer
atccccgattttgcaagaatgcctgaaaaa	Protospacer
*   ..**** ********** ********

19. spacer 2.16|474025|30|CP035154|CRISPRCasFinder,CRT matches to AP014207 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C8-MedDCM-OCT-S26-C6, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 7, identity: 0.767

atttatcataattatatccactacttaaat	CRISPR spacer
attgatcataattagatccactatgttttt	Protospacer
*** ********** ********. *   *

20. spacer 2.17|474091|30|CP035154|CRISPRCasFinder,CRT matches to NC_019699 (Chroococcidiopsis thermalis PCC 7203 plasmid pCHRO.01, complete sequence) position: , mismatch: 7, identity: 0.767

tcccatcctcccaaagccaattcgagcgga	CRISPR spacer
acccagcctcccaaagcaaattcgcactgt	Protospacer
 **** *********** ****** .* *

21. spacer 1.27|55320|28|CP035154|CRT matches to NZ_CP034087 (Methylocystis rosea strain GW6 plasmid pGW6_1, complete sequence) position: , mismatch: 8, identity: 0.714

gagttccgactcgatgtccaagtcagct	CRISPR spacer
gagttccgactcgatttccaaaaggcga	Protospacer
*************** *****.  .

22. spacer 2.8|473497|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP022035 (Salmonella enterica subsp. enterica serovar Onderstepoort str. SA20060086 plasmid punamed2, complete sequence) position: , mismatch: 8, identity: 0.733

acgtagtcggcattattaatacggtattga	CRISPR spacer
cgaaagtcagcattattaatgcggtatcgg	Protospacer
  . ****.***********.******.*.

23. spacer 2.8|473497|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP045959 (Salmonella enterica subsp. enterica serovar Birkenhead strain AUSMDU00010532 plasmid pAUSMDU00010532_01, complete sequence) position: , mismatch: 8, identity: 0.733

acgtagtcggcattattaatacggtattga	CRISPR spacer
cgaaagtcagcattattaatgcggtatcgg	Protospacer
  . ****.***********.******.*.

24. spacer 2.8|473497|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NC_019342 (Salmonella sp. 14 plasmid p14-120, complete sequence) position: , mismatch: 8, identity: 0.733

acgtagtcggcattattaatacggtattga	CRISPR spacer
cgaaagtcagcattattaatgcggtatcgg	Protospacer
  . ****.***********.******.*.

25. spacer 2.9|473563|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033050 (Virgibacillus halodenitrificans strain Bac324 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

gaagcaaataaaaacaccaaaaaggcgtct	CRISPR spacer
taagcaaataaaaacatcaaaataaagcat	Protospacer
 ***************.***** .. *. *

26. spacer 2.10|473629|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to MN694397 (Marine virus AFVG_250M51, complete genome) position: , mismatch: 8, identity: 0.733

aagattgattatgcaagaatgactgaaaaa	CRISPR spacer
tggcaagaatatgcaagaatgactgaagat	Protospacer
 .*   ** ******************.*

27. spacer 2.2|473101|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP032695 (Rhizobium jaguaris strain CCGE525 plasmid pRCCGE525c, complete sequence) position: , mismatch: 9, identity: 0.7

gaagcggacattgcttcggcaaaggcggaa	CRISPR spacer
cgctctcccactgcttcggcaaaggcggat	Protospacer
 .  *   **.******************

28. spacer 2.2|473101|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP041042 (Paracoccus sp. AK26 plasmid pAK4, complete sequence) position: , mismatch: 9, identity: 0.7

gaagcggacattgcttcggcaaaggcggaa	CRISPR spacer
acgaaggtctttgcttcggcaaaggcggtg	Protospacer
. .. ** * ****************** .

29. spacer 2.5|473299|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR214939 (Mycoplasma salivarium strain NCTC10113 plasmid 2) position: , mismatch: 9, identity: 0.7

ctcaaattgttgaagcgaatattaagttcg	CRISPR spacer
aagaaattgttgaaaagaatattaagaaaa	Protospacer
   ***********. **********   .

30. spacer 2.9|473563|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP024587 (Roseomonas sp. FDAARGOS_362 plasmid unnamed3, complete sequence) position: , mismatch: 9, identity: 0.7

gaagcaaataaaaacaccaaaaaggcgtct	CRISPR spacer
atgctaaatataaacaccaaaaagacgtta	Protospacer
. . .***** *************.***.

31. spacer 2.13|473827|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to MN693447 (Marine virus AFVG_25M466, complete genome) position: , mismatch: 10, identity: 0.667

taggcagtgttgcatttgccgcaattccgc	CRISPR spacer
ctatagcagttgcatttgccgcacttccga	Protospacer
. .  .  *************** *****

32. spacer 2.13|473827|30|CP035154|PILER-CR,CRISPRCasFinder,CRT matches to MN693479 (Marine virus AFVG_25M465, complete genome) position: , mismatch: 10, identity: 0.667

taggcagtgttgcatttgccgcaattccgc	CRISPR spacer
ctatagcagttgcatttgccgcacttccga	Protospacer
. .  .  *************** *****

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

419940 : 497396

Lactobacillus_phage(41.67%)

portal,capsid,protease,terminase,integrase,holin,tail

attL 421361:421376|attR 468033:468048

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QAR86276.1\|419940_421863_+	heavy metal translocating P-type ATPase	E4ZFI9	Streptococcus_phage	3.4e-87	32.5
421361:421376	attL	NA	NA	NA	NA
QAR86277.1\|421935_423489_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	2.8e-15	27.8
QAR86278.1\|423636_424812_-\|integrase	site-specific integrase	A8ATJ6	Listeria_phage	5.1e-46	29.2
QAR86279.1\|424899_425133_-	hypothetical protein	NA	NA	NA	NA
QAR86280.1\|425209_426391_-	DUF805 domain-containing protein	D6PSS5	Lactobacillus_phage	7.8e-18	36.2
QAR87754.1\|426427_427345_-	DUF4428 domain-containing protein	O48432	Lactobacillus_phage	1.9e-16	24.9
QAR86281.1\|427371_427776_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
QAR86282.1\|427787_428162_-	XRE family transcriptional regulator	A8ATX5	Listeria_phage	6.3e-06	33.0
QAR86283.1\|428328_428550_+	XRE family transcriptional regulator	Q6SEA0	Lactobacillus_prophage	4.4e-07	43.8
QAR86284.1\|428584_428800_+	hypothetical protein	NA	NA	NA	NA
QAR86285.1\|428882_429350_+	XRE family transcriptional regulator	NA	NA	NA	NA
QAR86286.1\|429331_429604_+	hypothetical protein	NA	NA	NA	NA
QAR86287.1\|429850_430744_+	DUF1351 domain-containing protein	U5U3Y3	Lactobacillus_phage	1.3e-25	31.4
QAR86288.1\|430746_431583_+	hypothetical protein	Q9G0C9	Lactococcus_phage	1.5e-12	41.9
QAR86289.1\|431575_432412_+	helix-turn-helix domain-containing protein	A0A097BYA5	Leuconostoc_phage	1.3e-43	52.8
QAR86290.1\|432416_433139_+	hypothetical protein	E9LUU3	Lactobacillus_phage	3.1e-86	67.0
QAR86291.1\|433083_433491_+	hypothetical protein	NA	NA	NA	NA
QAR86292.1\|433493_433940_+	single-stranded DNA-binding protein	A0A2D1GPB7	Lactobacillus_phage	2.8e-37	62.5
QAR86293.1\|433950_434298_+	DUF1642 domain-containing protein	NA	NA	NA	NA
QAR86294.1\|434294_434519_+	hypothetical protein	NA	NA	NA	NA
QAR86295.1\|434988_435468_+	hypothetical protein	NA	NA	NA	NA
QAR86296.1\|436080_436749_+	hypothetical protein	NA	NA	NA	NA
QAR86297.1\|436817_437504_+\|terminase	terminase	V5URT8	Oenococcus_phage	2.5e-16	42.5
QAR86298.1\|437487_438801_+\|terminase	PBSX family phage terminase large subunit	A0A286QNX6	Streptococcus_phage	3.3e-150	60.5
QAR86299.1\|438812_440342_+\|portal	phage portal protein	O03928	Lactobacillus_phage	2.3e-147	54.2
QAR86300.1\|440338_441472_+\|capsid	capsid protein	U3PFU0	Lactobacillus_phage	1.4e-56	35.0
QAR86301.1\|441571_442144_+	scaffolding protein	Q9T1B8	Listeria_phage	4.6e-24	39.2
QAR86302.1\|442156_443026_+\|capsid	capsid protein	U3PDP8	Lactobacillus_phage	3.3e-106	66.8
QAR86303.1\|443096_443513_+	hypothetical protein	NA	NA	NA	NA
QAR86304.1\|443509_443860_+\|capsid	capsid protein	O03932	Lactobacillus_phage	1.3e-26	56.3
QAR86305.1\|443859_444204_+\|capsid	capsid protein	O03933	Lactobacillus_phage	1.0e-15	44.1
QAR86306.1\|444204_444600_+\|capsid	minor capsid protein	B3GW09	Streptococcus_phage	8.9e-11	32.5
QAR86307.1\|445305_445686_+	Ig domain-containing protein	G0YPJ0	Erwinia_phage	9.8e-15	50.0
QAR86308.1\|445759_446152_+	hypothetical protein	NA	NA	NA	NA
QAR86309.1\|446161_446791_+	hypothetical protein	O03936	Lactobacillus_phage	2.3e-32	39.6
QAR86310.1\|452270_453182_+\|tail	phage tail family protein	M4ZS20	Bacillus_phage	3.3e-16	25.9
QAR86311.1\|453187_454309_+	hypothetical protein	O03938	Lactobacillus_phage	2.0e-79	43.0
QAR86312.1\|454301_454550_+	hypothetical protein	NA	NA	NA	NA
QAR86313.1\|454552_454876_+	hypothetical protein	NA	NA	NA	NA
QAR86314.1\|454875_456756_+	DUF2479 domain-containing protein	O03968	Lactobacillus_phage	1.5e-95	36.5
QAR86315.1\|456767_457496_+	hypothetical protein	NA	NA	NA	NA
QAR86316.1\|457517_457847_+	DUF2977 domain-containing protein	NA	NA	NA	NA
QAR86317.1\|457846_457978_+	XkdX family protein	NA	NA	NA	NA
QAR86318.1\|457997_458312_+	hypothetical protein	NA	NA	NA	NA
QAR86319.1\|458311_458554_+\|holin	holin	A0A2H4PBB2	Lactobacillus_phage	1.5e-05	63.2
QAR86320.1\|458537_459659_+	N-acetylmuramoyl-L-alanine amidase	A0A0N7IR99	Lactobacillus_phage	2.1e-97	52.9
QAR86321.1\|459767_460034_+	hypothetical protein	NA	NA	NA	NA
QAR86322.1\|461024_461669_+	SDR family oxidoreductase	NA	NA	NA	NA
QAR86323.1\|461861_463271_+	MFS transporter	NA	NA	NA	NA
QAR86324.1\|463297_465832_+	M1 family peptidase	A0A0P0IY26	Acinetobacter_phage	8.4e-70	27.3
QAR86325.1\|466059_466641_-	hypothetical protein	NA	NA	NA	NA
QAR86326.1\|466824_470898_+	type II CRISPR RNA-guided endonuclease Cas9	NA	NA	NA	NA
468033:468048	attR	NA	NA	NA	NA
QAR86327.1\|471113_472019_+	type II CRISPR-associated endonuclease Cas1	NA	NA	NA	NA
QAR86328.1\|471996_472302_+	CRISPR-associated endonuclease Cas2	NA	NA	NA	NA
QAR86329.1\|472298_472970_+	type II-A CRISPR-associated protein Csn2	NA	NA	NA	NA
QAR86330.1\|475673_476321_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
QAR86331.1\|476510_476795_+	co-chaperone GroES	A0A221S331	uncultured_virus	5.8e-12	38.9
QAR86332.1\|476817_478440_+	chaperonin GroEL	A0A240F766	uncultured_virus	6.6e-161	55.8
QAR86333.1\|478739_480572_+	APC family permease	NA	NA	NA	NA
QAR86334.1\|480793_481969_+	undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase	NA	NA	NA	NA
QAR86335.1\|482036_482675_-	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	1.1e-39	43.8
QAR86336.1\|482706_484026_+	DNA/RNA helicase	A0A1X9I5S6	Streptococcus_phage	5.3e-84	43.0
QAR87755.1\|484310_484697_+	ComF family protein	NA	NA	NA	NA
QAR86337.1\|484825_485380_+	ribosome-associated translation inhibitor RaiA	NA	NA	NA	NA
QAR86338.1\|485528_487892_+	preprotein translocase subunit SecA	NA	NA	NA	NA
QAR86339.1\|487969_489085_+	peptide chain release factor 2	NA	NA	NA	NA
QAR86340.1\|489097_489802_+	response regulator transcription factor	W8CYM9	Bacillus_phage	5.6e-40	39.2
QAR86341.1\|489773_491162_+	two-component sensor histidine kinase	NA	NA	NA	NA
QAR86342.1\|491389_492271_+	phosphate ABC transporter substrate-binding protein PstS family protein	NA	NA	NA	NA
QAR86343.1\|492263_493178_+	phosphate ABC transporter permease subunit PstC	NA	NA	NA	NA
QAR86344.1\|493174_494062_+	phosphate ABC transporter permease PstA	NA	NA	NA	NA
QAR86345.1\|494066_494873_+	phosphate ABC transporter ATP-binding protein	Q6GZ03	Mycoplasma_phage	1.5e-09	43.2
QAR86346.1\|494885_495644_+	phosphate ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	9.7e-14	30.8
QAR86347.1\|495656_496319_+	phosphate signaling complex protein PhoU	NA	NA	NA	NA
QAR86348.1\|496703_497018_+	PspC domain-containing protein	NA	NA	NA	NA
QAR86349.1\|497036_497396_+\|holin	phage holin family protein	NA	NA	NA	NA

DBSCAN-SWA_2

554270 : 621399

Indivirus(16.67%)

transposase,tRNA,protease,integrase

attL 583191:583207|attR 611734:611750

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QAR86403.1\|554270_555662_+\|tRNA	asparagine--tRNA ligase	A0A1V0SDB6	Indivirus	1.3e-72	35.9
QAR86404.1\|555760_557140_-	C69 family dipeptidase	NA	NA	NA	NA
QAR86405.1\|562318_562993_+\|transposase	transposase	A0A0C5AJ29	Paenibacillus_phage	1.4e-32	36.8
QAR86406.1\|562989_563883_+\|transposase	IS3 family transposase	A0A2I7SC85	Paenibacillus_phage	1.6e-07	25.4
QAR86407.1\|564018_564672_-	energy-coupling factor transporter transmembrane protein EcfT	NA	NA	NA	NA
QAR86408.1\|564655_566083_-	ABC transporter ATP-binding protein	A0A1V0SE00	Indivirus	8.5e-11	26.3
QAR86409.1\|566093_566669_-	ABC transporter permease	NA	NA	NA	NA
QAR86410.1\|567117_567858_+	glucose 1-dehydrogenase	Q06VL0	Trichoplusia_ni_ascovirus	6.3e-18	32.3
QAR86411.1\|567948_568401_-	DUF3021 domain-containing protein	NA	NA	NA	NA
QAR86412.1\|568412_568865_-	LytTR family transcriptional regulator	NA	NA	NA	NA
QAR86413.1\|568890_569751_-	multidrug ABC transporter permease	NA	NA	NA	NA
QAR86414.1\|569752_570646_-	ABC transporter ATP-binding protein	W5SAS9	Pithovirus	7.7e-18	30.7
QAR86415.1\|571132_573283_+	anaerobic ribonucleoside-triphosphate reductase	A0A0C5KKX3	Enterococcus_phage	6.1e-255	59.4
QAR86416.1\|573293_573881_+	anaerobic ribonucleoside-triphosphate reductase activating protein	A0A0C5K925	Enterococcus_phage	2.6e-51	53.8
QAR86417.1\|573895_574672_+	Fe-S cluster assembly ATPase SufC	A0A285PWH2	Cedratvirus	2.4e-07	24.6
QAR87756.1\|574652_575714_+	Fe-S cluster assembly protein SufD	NA	NA	NA	NA
QAR86418.1\|575715_576891_+	SufS family cysteine desulfurase	Q2XUY6	environmental_halophage	3.4e-82	40.9
QAR86419.1\|576887_577328_+	SUF system NifU family Fe-S cluster assembly protein	NA	NA	NA	NA
QAR86420.1\|577320_578727_+	Fe-S cluster assembly protein SufB	NA	NA	NA	NA
QAR86421.1\|578778_579252_+	hypothetical protein	NA	NA	NA	NA
QAR86422.1\|579456_580080_-	MarC family protein	NA	NA	NA	NA
QAR86423.1\|580479_580686_+	hypothetical protein	NA	NA	NA	NA
QAR86424.1\|580743_581343_+	hypothetical protein	NA	NA	NA	NA
QAR86425.1\|581406_581739_+	hypothetical protein	NA	NA	NA	NA
QAR86426.1\|581822_582965_-	ArgE/DapE family deacylase	NA	NA	NA	NA
583191:583207	attL	NA	NA	NA	NA
QAR86427.1\|583376_584312_+	NADP-dependent oxidoreductase	NA	NA	NA	NA
QAR86428.1\|584488_585526_+	Zn-dependent alcohol dehydrogenase	A0A0G2Y405	Acanthamoeba_polyphaga_mimivirus	3.7e-08	30.8
QAR86429.1\|586254_587424_-	serine/threonine protein phosphatase	NA	NA	NA	NA
QAR86430.1\|588024_589041_-	general stress protein	NA	NA	NA	NA
QAR87757.1\|589062_590433_-	MFS transporter	NA	NA	NA	NA
QAR86431.1\|590575_590824_-	GlsB/YeaQ/YmgE family stress response membrane protein	NA	NA	NA	NA
QAR86432.1\|591222_591369_-	ABC transporter ATP-binding protein	NA	NA	NA	NA
QAR86433.1\|592619_594284_-	glycosyltransferase family 8 protein	NA	NA	NA	NA
QAR86434.1\|594386_594479_-	ABC transporter ATP-binding protein	NA	NA	NA	NA
QAR86435.1\|595412_596351_+\|transposase	IS3 family transposase	NA	NA	NA	NA
QAR86436.1\|598124_599021_-\|transposase	IS3 family transposase	A0A1B1P773	Bacillus_phage	6.0e-39	36.2
QAR86437.1\|598975_599491_-	helix-turn-helix domain-containing protein	NA	NA	NA	NA
QAR86438.1\|599573_600908_-	NAD(P)/FAD-dependent oxidoreductase	A0A2K5B2C5	Erysipelothrix_phage	1.5e-30	27.6
QAR86439.1\|601060_601591_-	MFS transporter	NA	NA	NA	NA
QAR87758.1\|601605_601839_-	hypothetical protein	NA	NA	NA	NA
QAR86440.1\|602436_603387_+	magnesium transporter CorA family protein	NA	NA	NA	NA
QAR87759.1\|603302_603833_-	recombinase family protein	A0A0A8WIK3	Clostridium_phage	7.2e-16	38.7
QAR86441.1\|605694_606027_+	hypothetical protein	NA	NA	NA	NA
QAR86442.1\|606538_608104_-	recombinase RecD	NA	NA	NA	NA
QAR86443.1\|608542_608908_-	hypothetical protein	NA	NA	NA	NA
QAR86444.1\|609062_609293_-	DNA-binding protein	NA	NA	NA	NA
QAR86445.1\|609940_611095_+\|integrase	site-specific integrase	A0A097PAS9	Streptococcus_pyogenes_phage	1.0e-59	37.2
QAR86446.1\|611909_612722_+	LicD family protein	A0A1V0SD50	Indivirus	7.7e-09	53.4
611734:611750	attR	NA	NA	NA	NA
QAR87760.1\|612746_613547_+	DUF1211 domain-containing protein	NA	NA	NA	NA
QAR86447.1\|613907_614507_+	chitin-binding protein	A0A0K1Y848	Apis_mellifera_filamentous_virus	2.6e-14	29.4
QAR86448.1\|614830_615055_-	CsbD family protein	NA	NA	NA	NA
QAR86449.1\|615450_616245_+	hydroxyethylthiazole kinase	NA	NA	NA	NA
QAR86450.1\|616241_617072_+	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	NA	NA	NA	NA
QAR86451.1\|617061_617742_+	thiamine phosphate synthase	NA	NA	NA	NA
QAR86452.1\|617723_618401_+	thiaminase II	NA	NA	NA	NA
QAR86453.1\|618794_620549_+	DNA helicase RecQ	A0A2K9L3P7	Tupanvirus	7.4e-73	37.0
QAR86454.1\|620685_621399_+\|protease	matrixin family metalloprotease	NA	NA	NA	NA

DBSCAN-SWA_3

665046 : 776109

130

Lactobacillus_phage(56.92%)

portal,capsid,head,protease,terminase,integrase,holin,tRNA,tail

attL 668031:668047|attR 750646:750662

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QAR86493.1\|665046_666183_-\|integrase	site-specific integrase	E9LUS1	Lactobacillus_phage	2.8e-89	46.8
QAR86494.1\|666357_666909_+	hypothetical protein	NA	NA	NA	NA
QAR86495.1\|667135_668026_-	DUF5067 domain-containing protein	NA	NA	NA	NA
668031:668047	attL	NA	NA	NA	NA
QAR86496.1\|668094_668493_-	hypothetical protein	NA	NA	NA	NA
QAR86497.1\|668527_668959_-	PH domain-containing protein	NA	NA	NA	NA
QAR87762.1\|669015_669336_-	ImmA/IrrE family metallo-endopeptidase	D6PSS8	Lactobacillus_phage	1.2e-13	42.7
QAR86498.1\|669470_669812_-	XRE family transcriptional regulator	D2IZV9	Enterococcus_phage	2.1e-16	39.0
QAR86499.1\|670069_670279_+	XRE family transcriptional regulator	NA	NA	NA	NA
QAR86500.1\|670292_671027_+	phage regulatory protein	D2IYT0	Enterococcus_phage	8.7e-52	49.8
QAR86501.1\|671232_671571_+	DUF771 domain-containing protein	NA	NA	NA	NA
QAR86502.1\|671811_672267_+	chromosome segregation protein SMC	NA	NA	NA	NA
QAR86503.1\|672267_672993_+	Erf family protein	I6TJU2	Staphylococcus_virus	2.1e-21	38.3
QAR86504.1\|672985_673192_+	hypothetical protein	NA	NA	NA	NA
QAR86505.1\|673184_673610_+	single-stranded DNA-binding protein	A0A2D1GPB7	Lactobacillus_phage	1.2e-42	59.6
QAR86506.1\|673620_674298_+	hypothetical protein	E9LUU3	Lactobacillus_phage	1.1e-82	65.6
QAR86507.1\|674287_674512_+	hypothetical protein	NA	NA	NA	NA
QAR86508.1\|674549_675272_+	hypothetical protein	E9LUM6	Lactobacillus_phage	2.8e-79	61.0
QAR86509.1\|675252_676068_+	ATP-binding protein	O03914	Lactobacillus_phage	2.4e-58	46.0
QAR86510.1\|676185_676818_+	RNA polymerase subunit sigma-70	NA	NA	NA	NA
QAR86511.1\|676798_677200_+	RusA family crossover junction endodeoxyribonuclease	A8YQM5	Lactobacillus_phage	2.4e-27	46.3
QAR86512.1\|677333_677705_+	N-acetylmuramoyl-L-alanine amidase	NA	NA	NA	NA
QAR86513.1\|677753_678176_+	hypothetical protein	NA	NA	NA	NA
QAR86514.1\|678226_678469_+	hypothetical protein	A0A2K9VC51	Lactobacillus_phage	6.4e-20	57.1
QAR86515.1\|678674_678857_+	hypothetical protein	NA	NA	NA	NA
QAR86516.1\|679296_679731_+	RNA polymerase subunit sigma-70	NA	NA	NA	NA
QAR86517.1\|680197_680722_+\|terminase	terminase small subunit	A0A097BYC9	Leuconostoc_phage	2.4e-43	64.4
QAR86518.1\|680705_681980_+\|terminase	PBSX family phage terminase large subunit	Q6SE84	Lactobacillus_prophage	4.2e-171	68.5
QAR87763.1\|682040_683396_+\|portal	phage portal protein	A0A0P0IJV3	Lactobacillus_phage	3.4e-142	58.8
QAR86519.1\|683364_684348_+\|head	phage head morphogenesis protein	A0A0P0ID43	Lactobacillus_phage	2.7e-80	49.7
QAR86520.1\|684450_685167_+	DUF4355 domain-containing protein	A0A0A1EN85	Lactobacillus_phage	7.3e-19	35.9
QAR86521.1\|685166_685985_+\|capsid	N4-gp56 family major capsid protein	B5SP31	Lactococcus_phage	1.6e-99	72.8
QAR86522.1\|686002_686269_+	hypothetical protein	K4ICY6	Lactobacillus_virus	1.0e-10	59.0
QAR86523.1\|686280_686655_+\|head,tail	phage head-tail connector protein	A0A0P0IV23	Lactobacillus_phage	6.7e-24	51.2
QAR86524.1\|686659_686965_+	hypothetical protein	A0A2P1JTW8	Anoxybacillus_phage	3.3e-05	31.7
QAR86525.1\|686957_687299_+	hypothetical protein	A0ZVS5	Lactococcus_phage	6.5e-18	44.3
QAR86526.1\|687299_687701_+	hypothetical protein	A0A097BYB7	Leuconostoc_phage	8.7e-22	39.8
QAR86527.1\|687721_688327_+\|tail	phage major tail protein, TP901-1 family	A0A0A1ELH3	Lactobacillus_phage	8.2e-48	54.2
QAR86528.1\|688404_688680_+	hypothetical protein	A0A220BYE2	Staphylococcus_phage	4.6e-06	52.8
QAR86529.1\|688688_689150_+	Ig domain-containing protein	NA	NA	NA	NA
QAR86530.1\|689212_689548_+	hypothetical protein	A0A0A1ER95	Lactobacillus_phage	2.9e-26	57.7
QAR86531.1\|689592_689964_+	hypothetical protein	A0A1B0Y2Q4	Lactobacillus_phage	2.1e-17	42.6
QAR86532.1\|689947_692968_+\|tail	phage tail tape measure protein	A0A0A1ENQ9	Lactobacillus_phage	9.0e-111	62.3
QAR86533.1\|692968_693730_+\|tail	phage tail protein	A0A286QMT6	Streptococcus_phage	9.4e-41	41.2
QAR86534.1\|693729_696675_+	peptidase M23	Q6SEC2	Lactobacillus_prophage	4.1e-153	35.3
QAR86535.1\|696674_697088_+	hypothetical protein	NA	NA	NA	NA
QAR86536.1\|697091_698984_+	DUF2479 domain-containing protein	O03968	Lactobacillus_phage	2.1e-81	34.1
QAR86537.1\|698995_699733_+	hypothetical protein	NA	NA	NA	NA
QAR86538.1\|699744_700080_+	DUF2977 domain-containing protein	NA	NA	NA	NA
QAR86539.1\|700072_700198_+	XkdX family protein	NA	NA	NA	NA
QAR86540.1\|700233_700755_+\|holin	holin	NA	NA	NA	NA
QAR86541.1\|700751_701870_+	N-acetylmuramoyl-L-alanine amidase	A0A0N7IR99	Lactobacillus_phage	2.1e-97	52.9
QAR86542.1\|701885_702137_+	hypothetical protein	A0A182BQ93	Lactococcus_phage	1.1e-17	48.1
QAR86543.1\|703243_704221_+	GMP reductase	G3MBI2	Bacillus_virus	5.6e-139	73.8
QAR86544.1\|704445_706653_-\|protease	ATP-dependent Clp protease ATP-binding subunit	A0A223W0B1	Agrobacterium_phage	6.1e-125	40.3
QAR86545.1\|706868_707057_+	hypothetical protein	NA	NA	NA	NA
QAR86546.1\|707199_707466_+	phosphocarrier protein HPr	NA	NA	NA	NA
QAR86547.1\|707465_709190_+	phosphoenolpyruvate--protein phosphotransferase	A0A1V0SGR7	Hokovirus	9.0e-15	30.9
QAR86548.1\|709262_710036_+	alpha/beta hydrolase	NA	NA	NA	NA
QAR86549.1\|710121_711309_+	glycosyltransferase family 4 protein	NA	NA	NA	NA
QAR86550.1\|711339_712356_+	glycosyltransferase	NA	NA	NA	NA
QAR87764.1\|712402_713407_+	flippase-like domain-containing protein	NA	NA	NA	NA
QAR86551.1\|721003_721735_-	hypothetical protein	NA	NA	NA	NA
QAR86552.1\|721906_723097_+	methionine adenosyltransferase	A0A2H4PQS6	Staphylococcus_phage	5.0e-150	68.4
QAR86553.1\|723272_724742_+	DHA2 family efflux MFS transporter permease subunit	NA	NA	NA	NA
QAR86554.1\|724821_725385_-	methyltransferase domain-containing protein	A0A2H4PQV0	Staphylococcus_phage	5.9e-32	39.9
QAR86555.1\|725377_726013_-	phosphatase PAP2 family protein	NA	NA	NA	NA
QAR86556.1\|726418_728836_+\|tRNA	leucine--tRNA ligase	A0A2H4PQS0	Staphylococcus_phage	0.0e+00	68.0
QAR86557.1\|729092_730775_+	polysaccharide biosynthesis protein	NA	NA	NA	NA
QAR86558.1\|730785_731505_+	rRNA pseudouridine synthase	NA	NA	NA	NA
QAR86559.1\|731611_732442_-	NAD(P)H-hydrate dehydratase	NA	NA	NA	NA
QAR86560.1\|732567_733029_+	universal stress protein	NA	NA	NA	NA
QAR86561.1\|733358_733643_+	DUF2089 family protein	NA	NA	NA	NA
QAR86562.1\|733639_733933_+	hypothetical protein	NA	NA	NA	NA
QAR86563.1\|734016_735729_-	LPXTG cell wall anchor domain-containing protein	NA	NA	NA	NA
QAR86564.1\|735964_736624_-	deoxynucleoside kinase	C1KFI3	Lactobacillus_virus	3.8e-46	45.5
QAR86565.1\|737124_737943_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
QAR86566.1\|737944_738148_+	cytochrome aa3 quinol oxidase, subunit IV, qoxD	NA	NA	NA	NA
QAR86567.1\|738144_738363_+	AbrB protein	NA	NA	NA	NA
QAR86568.1\|738362_738641_+	heavy metal-binding domain-containing protein	NA	NA	NA	NA
QAR86569.1\|738758_738995_-	hypothetical protein	NA	NA	NA	NA
QAR86570.1\|739590_741471_+	asparagine synthase (glutamine-hydrolyzing)	NA	NA	NA	NA
QAR86571.1\|741489_743013_+	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase	NA	NA	NA	NA
QAR86572.1\|743012_744269_+	carboxylate--amine ligase	NA	NA	NA	NA
QAR86573.1\|744274_744982_+	amino acid racemase	NA	NA	NA	NA
QAR86574.1\|745073_745883_+	DNA/RNA non-specific endonuclease	NA	NA	NA	NA
QAR86575.1\|745965_746778_-	MurR/RpiR family transcriptional regulator	NA	NA	NA	NA
QAR86576.1\|747059_747749_-	N-acetylmannosamine-6-phosphate 2-epimerase	NA	NA	NA	NA
QAR86577.1\|748144_749224_-\|integrase	site-specific integrase	Q9ZXG6	Leuconostoc_phage	6.4e-43	35.7
QAR86578.1\|749444_749642_-	hypothetical protein	NA	NA	NA	NA
QAR86579.1\|749874_750678_-	DUF4352 domain-containing protein	Q9AZW5	Lactococcus_phage	9.3e-23	40.8
750646:750662	attR	NA	NA	NA	NA
QAR86580.1\|750712_751120_-	ImmA/IrrE family metallo-endopeptidase	NA	NA	NA	NA
QAR87765.1\|751131_751482_-	XRE family transcriptional regulator	A0A2P0ZLA1	Lactobacillus_phage	5.5e-20	44.9
QAR86581.1\|751753_751942_+	hypothetical protein	NA	NA	NA	NA
QAR86582.1\|751925_752159_+	DUF2829 domain-containing protein	A0A2H4J5N9	uncultured_Caudovirales_phage	4.3e-05	37.8
QAR86583.1\|752219_752945_+	phage regulatory protein	D2IYT0	Enterococcus_phage	1.2e-56	52.8
QAR86584.1\|753013_753220_+	hypothetical protein	NA	NA	NA	NA
QAR86585.1\|753316_753634_+	hypothetical protein	NA	NA	NA	NA
QAR86586.1\|753714_753927_+	hypothetical protein	NA	NA	NA	NA
QAR86587.1\|753936_754572_+	ERF superfamily protein	A0A1P8BK87	Lactococcus_phage	1.1e-05	36.2
QAR86588.1\|754574_754781_+	hypothetical protein	NA	NA	NA	NA
QAR86589.1\|754773_755199_+	single-stranded DNA-binding protein	A0A2D1GPB7	Lactobacillus_phage	9.5e-43	58.9
QAR86590.1\|755210_755888_+	hypothetical protein	E9LUU3	Lactobacillus_phage	4.1e-80	63.0
QAR86591.1\|755877_756102_+	hypothetical protein	NA	NA	NA	NA
QAR86592.1\|756105_756354_-	hypothetical protein	NA	NA	NA	NA
QAR86593.1\|756387_757149_+	hypothetical protein	A0A1W6JNI1	Staphylococcus_phage	2.9e-50	46.3
QAR86594.1\|757129_757945_+	ATP-binding protein	O03914	Lactobacillus_phage	2.6e-57	45.6
QAR86595.1\|758630_759077_+	RusA family crossover junction endodeoxyribonuclease	A8YQM5	Lactobacillus_phage	4.5e-27	45.6
QAR86596.1\|759209_759581_+	N-acetylmuramoyl-L-alanine amidase	NA	NA	NA	NA
QAR86597.1\|759747_760041_+	hypothetical protein	NA	NA	NA	NA
QAR86598.1\|760041_760287_+	hypothetical protein	NA	NA	NA	NA
QAR86599.1\|760673_760922_+	hypothetical protein	A0A2K9VC51	Lactobacillus_phage	3.7e-23	59.5
QAR86600.1\|761108_761297_+	hypothetical protein	NA	NA	NA	NA
QAR86601.1\|761496_761940_+	hypothetical protein	NA	NA	NA	NA
QAR86602.1\|762448_762700_+	hypothetical protein	NA	NA	NA	NA
QAR86603.1\|762703_763216_+	HNH endonuclease	E9LUP7	Lactobacillus_phage	5.8e-79	88.5
QAR86604.1\|763313_763571_+	hypothetical protein	NA	NA	NA	NA
QAR86605.1\|763761_764220_+\|terminase	phage terminase small subunit P27 family	E9LUP8	Lactobacillus_phage	3.0e-79	96.1
QAR86606.1\|764222_766121_+\|terminase	terminase large subunit	E9LUP9	Lactobacillus_phage	0.0e+00	95.3
QAR86607.1\|766110_766305_+	DUF1056 family protein	E9LUQ0	Lactobacillus_phage	1.2e-24	90.6
QAR86608.1\|766307_767471_+\|portal	phage portal protein	E9LUQ1	Lactobacillus_phage	1.6e-204	90.9
QAR86609.1\|767448_768195_+\|protease	Clp protease ClpP	E9LUQ2	Lactobacillus_phage	5.6e-123	93.1
QAR86610.1\|768194_769427_+\|capsid	phage major capsid protein	E9LUQ3	Lactobacillus_phage	1.1e-208	91.2
QAR86611.1\|769499_769832_+\|head,tail	phage gp6-like head-tail connector protein	E9LUQ4	Lactobacillus_phage	1.0e-44	85.2
QAR86612.1\|769821_770169_+\|head,tail	head-tail adaptor protein	A0A2P0ZLF0	Lactobacillus_phage	7.8e-43	71.9
QAR86613.1\|770171_770579_+	HK97 gp10 family phage protein	A0A2P0ZLE6	Lactobacillus_phage	3.3e-61	87.9
QAR86614.1\|770578_770959_+	DUF806 family protein	A0A2P0ZLF4	Lactobacillus_phage	1.5e-60	92.9
QAR86615.1\|770972_771659_+\|tail	phage tail protein	A0A2P0ZLH1	Lactobacillus_phage	1.9e-109	92.1
QAR86616.1\|771734_772109_+	hypothetical protein	A0A2P0ZLH4	Lactobacillus_phage	2.7e-57	94.4
QAR86617.1\|773732_774998_+	MFS transporter	NA	NA	NA	NA
QAR86618.1\|775080_776109_-	LacI family DNA-binding transcriptional regulator	C6ZCU4	Enterobacteria_phage	4.2e-12	24.9

DBSCAN-SWA_4

1090405 : 1098968

Synechococcus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QAR86916.1\|1090405_1090987_-	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	4.8e-21	34.1
QAR86917.1\|1090986_1092033_-	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3FC27	Synechococcus_phage	2.7e-54	37.4
QAR86918.1\|1092035_1093505_-	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	6.2e-57	34.1
QAR86919.1\|1093489_1095694_-	phosphoribosylformylglycinamidine synthase subunit PurL	A6N228	Microbacterium_phage	3.7e-146	40.9
QAR86920.1\|1095711_1096386_-	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
QAR86921.1\|1096382_1096643_-	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
QAR86922.1\|1096629_1097364_-	phosphoribosylaminoimidazolesuccinocarboxamide synthase	A0A1D7SLB8	Cyanophage	2.8e-42	42.5
QAR86923.1\|1097341_1098502_-	5-(carboxyamino)imidazole ribonucleotide synthase	NA	NA	NA	NA
QAR86924.1\|1098485_1098968_-	5-(carboxyamino)imidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	2.0e-17	39.7

DBSCAN-SWA_5

1130177 : 1137499

Staphylococcus_phage(28.57%)

tRNA

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QAR86957.1\|1130177_1131023_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	2.1e-17	35.6
QAR86958.1\|1131196_1131403_+	hypothetical protein	NA	NA	NA	NA
QAR86959.1\|1131419_1131902_-	dihydrofolate reductase	A0A076GDN3	Bacillus_phage	3.6e-22	39.1
QAR86960.1\|1131919_1132870_-	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	1.0e-113	59.6
QAR86961.1\|1132874_1134770_-	ABC transporter ATP-binding protein	A0A2K9L3Z8	Tupanvirus	1.9e-50	30.3
QAR86962.1\|1134772_1135981_-\|tRNA	CCA tRNA nucleotidyltransferase	H7BUW3	unidentified_phage	2.9e-44	34.5
QAR86963.1\|1136096_1136966_+	YitT family protein	M1Q1P6	Streptococcus_phage	1.2e-55	37.8
QAR86964.1\|1137028_1137499_-	nucleoside 2-deoxyribosyltransferase	K4I206	Lactobacillus_phage	2.7e-14	34.6

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. CP035154

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection