CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP035758	Ktedonobacterales bacterium SCAWS-G2 chromosome, complete genome	25 crisprs	csa3,WYL,cas6,Cas14u_CAS-V,RT,csx15,csx1,csx3,csm3gr7,csx10gr5,cas10,DinG,Cas9_archaeal,DEDDh,cas10d,csc2gr7,csc1gr5,cas4,cas14k,cas3,Cas14b_CAS-V-F,Cas14c_CAS-V-F	0	9	5	0

1. CP035758

CRISPR-Cas detection and classification

Crispr_ID: CP035758_2

• CRISPR_ID: CP035758_2
• CRISPR_location: 383499-383609
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP035758_2

Consensus_repeat	Method
CAGCTTCCTTTACCCGATAGCGAGTA	CRISPRCasFinder

spacers of CP035758_2

>2.1|383525|59|CP035758|CRISPRCasFinder
GAAAGAAAATCATTATGCCAATACAACCCAGATCATCTCAGACACCTTCCTCTCGTGAA

CRISPR arrays and Neighbor proteins around CP035758_2

CRISPR arrays

The CRISPR arrays of CP035758_2

>merge|CP035758|2|383499-383609|CRISPRCasFinder
CAGCTTCCTTTACCCGATAGCGAGTAGAAAGAAAATCATTATGCCAATACAACCCAGATCATCTCAGACACCTTCCTCTCGTGAACAGCTTCCTTCACCCGATAGCGAGTA

>CP035758|2|2|383499-383609|CRISPRCasFinder
CAGCTTCCTTTACCCGATAGCGAGTA	GAAAGAAAATCATTATGCCAATACAACCCAGATCATCTCAGACACCTTCCTCTCGTGAA
CAGCTTCCTTCACCCGATAGCGAGTA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD74782.1|377960_379625_+|beta-N-acetylglucosaminidase	unknown	unknown	gnl|CDD|119333
CP035758.1|QBD74792.1|390679_391483_-|creatininase-family-protein	unknown	unknown	gnl|CDD|376872
CP035758.1|QBD74796.1|396278_396881_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
CP035758.1|QBD74788.1|385061_386246_-|Gfo/Idh/MocA-family-oxidoreductase	unknown	unknown	gnl|CDD|223745
CP035758.1|QBD74785.1|381443_382457_-|chitin-binding-protein	unknown	unknown	gnl|CDD|376983
CP035758.1|QBD74790.1|388284_389865_-|hypothetical-protein	unknown	unknown	gnl|CDD|198374
CP035758.1|QBD83345.1|386496_386907_+|OsmC-family-peroxiredoxin	unknown	unknown	gnl|CDD|182688
CP035758.1|QBD74789.1|387094_388276_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD74780.1|375898_376630_-|SMI1/KNR4-family-protein	unknown	unknown	gnl|CDD|378155
CP035758.1|QBD74778.1|373914_374724_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
CP035758.1|QBD74783.1|379684_380653_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	unknown	unknown	gnl|CDD|235580
CP035758.1|QBD74791.1|389861_390680_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225099
CP035758.1|QBD74776.1|371908_372742_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
CP035758.1|QBD74784.1|380997_381261_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl|CDD|225170
CP035758.1|QBD74793.1|391636_392389_-|HD-domain-containing-protein	unknown	unknown	gnl|CDD|238032
CP035758.1|QBD74795.1|395000_395762_-|hypothetical-protein	unknown	unknown	gnl|CDD|197320
CP035758.1|QBD74779.1|375285_375753_+|NUDIX-domain-containing-protein	unknown	unknown	gnl|CDD|240043
CP035758.1|QBD74794.1|393148_394888_+|peptide-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl|CDD|173869
CP035758.1|QBD74777.1|372984_373836_+|SMP-30/gluconolactonase/LRE-family-protein	unknown	unknown	gnl|CDD|369882
CP035758.1|QBD74781.1|376820_377762_+|EamA-family-transporter	unknown	unknown	gnl|CDD|273359

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD74782.1|377960_379625_+|beta-N-acetylglucosaminidase	gnl|CDD|119333	cd06563, GH20_chitobiase-like, The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a chitinase hydrolyzes the chitin to oligosaccharides and disaccharides such as di-N-acetyl-D-glucosamine and chitobiose, ii) chitobiase then further degrades these oligomers into monomers. This GH20 domain family includes an N-acetylglucosamidase (GlcNAcase A) from Pseudoalteromonas piscicida and an N-acetylhexosaminidase (SpHex) from Streptomyces plicatus. SpHex lacks the C-terminal PKD (polycystic kidney disease I)-like domain found in the chitobiases. The GH20 hexosaminidases are thought to act via a catalytic mechanism in which the catalytic nucleophile is not provided by solvent or the enzyme, but by the substrate itself.	0
CP035758.1|QBD74792.1|390679_391483_-|creatininase-family-protein	gnl|CDD|376872	pfam02633, Creatininase, Creatinine amidohydrolase. Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyzes the hydrolysis of creatinine to creatine.	3.70529e-70
CP035758.1|QBD74796.1|396278_396881_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.53533e-15
CP035758.1|QBD74788.1|385061_386246_-|Gfo/Idh/MocA-family-oxidoreductase	gnl|CDD|223745	COG0673, MviM, Predicted dehydrogenases and related proteins [General function prediction only].	4.776e-25
CP035758.1|QBD74785.1|381443_382457_-|chitin-binding-protein	gnl|CDD|376983	pfam03067, LPMO_10, Lytic polysaccharide mono-oxygenase, cellulose-degrading. This domain is found associated with a wide variety of cellulose binding domains. This is a family of two very closely related proteins that together act as both a C1- and a C4-oxidising lytic polysaccharide mono-oxygenase, degrading cellulose. This domain is also found in baculoviral spheroidins and spindolins, protein of unknown function.	5.37821e-66
CP035758.1|QBD74790.1|388284_389865_-|hypothetical-protein	gnl|CDD|198374	cd07808, FGGY_D-XK_EcXK-like, Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases. This subgroup is predominantly composed of bacterial D-xylulose kinases (XK, also known as xylulokinase; EC 2.7.1.17), which catalyze the rate-limiting step in the ATP-dependent phosphorylation of D-xylulose to produce D-xylulose 5-phosphate (X5P) and ADP. D-xylulose has been used as a source of carbon and energy by a variety of microorganisms. Some uncharacterized sequences are also included in this subgroup. The prototypical member of this CD is Escherichia coli xylulokinase (EcXK), which exists as a dimer. Each monomer consists of two large domains separated by an open cleft that forms an active site. This model includes both the N-terminal domain, which adopts a ribonuclease H-like fold, and the structurally related C-terminal domain. The presence of Mg2+ or Mn2+ is required for catalytic activity. Members of this subgroup belong to the FGGY family of carbohydrate kinases.	8.53305e-119
CP035758.1|QBD83345.1|386496_386907_+|OsmC-family-peroxiredoxin	gnl|CDD|182688	PRK10738, PRK10738, OsmC family protein.	3.78516e-32
CP035758.1|QBD74780.1|375898_376630_-|SMI1/KNR4-family-protein	gnl|CDD|378155	pfam09346, SMI1_KNR4, SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.	0.00526481
CP035758.1|QBD74778.1|373914_374724_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.12306e-15
CP035758.1|QBD74783.1|379684_380653_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha	gnl|CDD|235580	PRK05724, PRK05724, acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated.	7.52284e-159
CP035758.1|QBD74791.1|389861_390680_-|GntR-family-transcriptional-regulator	gnl|CDD|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	1.39873e-56
CP035758.1|QBD74776.1|371908_372742_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.01823e-19
CP035758.1|QBD74784.1|380997_381261_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl|CDD|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	1.85677e-06
CP035758.1|QBD74793.1|391636_392389_-|HD-domain-containing-protein	gnl|CDD|238032	cd00077, HDc, Metal dependent phosphohydrolases with conserved 'HD' motif.	0.00416506
CP035758.1|QBD74795.1|395000_395762_-|hypothetical-protein	gnl|CDD|197320	cd09086, ExoIII-like_AP-endo, Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases. This subfamily includes Escherichia coli ExoIII, Neisseria meningitides NExo,and related proteins. These are ExoIII family AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiencies. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity. For example, Neisseria meningitides Nape and NExo, and exonuclease III (ExoIII) and endonuclease IV (EndoIV) in Escherichia coli. NExo and ExoIII are found in this subfamily. NExo is the non-dominant AP endonuclease. It exhibits strong 3'-5' exonuclease and 3'-deoxyribose phosphodiesterase activities. Escherichia coli ExoIII is an active AP endonuclease, and in addition, it exhibits double strand (ds)-specific 3'-5' exonuclease, exonucleolytic RNase H, 3'-phosphomonoesterase and 3'-phosphodiesterase activities, all catalyzed by a single active site. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes ExoIII and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	1.91308e-21
CP035758.1|QBD74779.1|375285_375753_+|NUDIX-domain-containing-protein	gnl|CDD|240043	cd04687, Nudix_Hydrolase_28, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	4.86022e-42
CP035758.1|QBD74794.1|393148_394888_+|peptide-ABC-transporter-substrate-binding-protein	gnl|CDD|173869	cd08504, PBP2_OppA, The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold. This family represents the periplasmic substrate-binding component of an ATP-binding cassette (ABC)-type oligopeptide transport system comprised of 5 subunits. The transport system OppABCDEF contains two homologous integral membrane proteins OppB and OppF that form the translocation pore; two homologous nucleotide-binding domains OppD and OppF that drive the transport process through binding and hydrolysis of ATP; and the substrate-binding protein or receptor OppA that determines the substrate specificity of the transport system. The dipeptide (DppA) and oligopeptide (OppA) binding proteins differ in several ways. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	6.17748e-110
CP035758.1|QBD74777.1|372984_373836_+|SMP-30/gluconolactonase/LRE-family-protein	gnl|CDD|369882	pfam08450, SGL, SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyze diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.	7.82677e-52
CP035758.1|QBD74781.1|376820_377762_+|EamA-family-transporter	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	8.12744e-24

Protein sequences

>CP035758.1|QBD74785.1|381443_382457_-|chitin-binding-protein
MAASLAFIIKKRWALICVVFLIVTSVLVLPEIASPVQAHGAMSVPISRVYGCFLEGPEHPTTPACQYAVSVGGTQPLYDWNEVHLLNANGQSRQLIPDGHLCSAGTTKYAVFDTPRTDWPSTNVQAGVPYTFQYRATAPHRGTFDLYITKDGYDPTQPLKWSDLEDQPFLSATDPPLVNGVYQMQGTMPAGKTGHHLIYSIWQRSDSPEAFYTCSDVIFGGSGPTPTPTPVPPTGSCKANVNIDSSWQSGYQATITVQNTGTAAVDDWMVDWTMPAGVTITSGWNATVSQDGTMGMAKAPSWARTLDAGASVSIGFNATGSSSPPPSGVVLDGISCT
>CP035758.1|QBD74784.1|380997_381261_+|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MLTAILVWLLVGLIAGFLASVVMRGGGYGVVGDIIVGLVGALIGGFLANLLGLGASGLIGSIIIAFIGACILIAILRAVSSSTRRAL
>CP035758.1|QBD74783.1|379684_380653_-|acetyl-CoA-carboxylase-carboxyltransferase-subunit-alpha
MAYDLPFEKPLADLEARIAKLKRKGERLKADERAQLQQAEQELQQLTQEIYGKLSAWQTVMVARHKDRPHAIDYLNLICDAFFELHGDRRAADNPTIVGGPANFGGRTVMFIGQEKGRGLKDQRLRHAGQTHPEGHRKAYRLMQQAEKFHFPIVYLIDTPGASIALEDEERGQATSVAENLYLMASLKVPTISVIIGEGGSGGALALGIADRVLMQAYSYYTVASPESAATIMWRDAKYAPEAAEAMQITARQVKTHGLIDDIIAEPAGGAHKDHQAAALLLKEKLLVHLQALCQLSLDELLVQRYSKLRSVGRFAEPGIAS
>CP035758.1|QBD74782.1|377960_379625_+|beta-N-acetylglucosaminidase
MDQQTHNAHFNSAILPQPVSITYDEGYFQLTPNTVIVADEQTQAIGTLLAETLAPASGYALRVVTNKPQDLAVISLAIDPTLTHLGKEGYALQVTRQQVTIRGTHPVGVFYGTQTLRQLLPTDIFSTTLIKRDWPIPAVSIEDYPHFAWRGLMLDPARHFIPKDGILKFIDLLALHKMNVLHLHLTDDQGWRIEIKRYPKLTEIGSQRKETIIGHNNNPKGYDGKPHGGFYTQDDIREIVAYASARGITVVPEIDMPGHAQAAIASYPELGVIDEPVEVGTHWGINPYLYSPSDETIEFLHNILAEVIELFPSLYIHVGGDEATKEQWQASAKVQARIKELGLKDEDELQSWFIQQMGIFLKQKGRKLLGWDEILEGGLPPEATVMSWRGIVGGIEAARARHDVIMAPFTHVYFDYYQSNDPKEPLAIGGYTPLSKVYAFNPYPAELTAEELQHILGAQCTLWSEYIDSPSHLEYMAFPRAIAVAEVVWTPKERCDFTSFCQRLAVHEARLTHLEVNFRPIESLTHESTFPERLSPWQLAASESTLSEDEGESA
>CP035758.1|QBD74781.1|376820_377762_+|EamA-family-transporter
MPKWFARTRGLALANIAVLFFGLAGVLGKLSALPSPIITLTRVVFAGLVLIIVALFQRTPLRPASRRDGWILCAQGALLALHWTSFFQSINVSSVAIGLLSFSSFPLLTALLEPLILQQRPTRIQIFAALLVLPGIYLLVPSFSVQNNTTLGVLWGLLAGATFALLSVTNRWLGRSYPSLTISLYQDSVAALVLLPTLFLIPVTLSWTPRELLILLILGICCTALAHTLFISSMRTITAQAASLLANLEPVWGILFGIALLHEFPAPSTWLGGAIILFATLLPAFFGLLRQRREQQPSHNPQTIDKPSNLKNL
>CP035758.1|QBD74780.1|375898_376630_-|SMI1/KNR4-family-protein
MANSIPQHFDEAFLRWFQERTELAWQSYQTRTFEDFVASGVGGRDWQQGTCWSGGLSEQEIVAVEQRFHTHFPPDYRLFLQQLHSVDRLLVGARYADDNTMIPITAPSFYHWQRDTEAIEAAYAWLVKGLYFDVQHANLWPQSWGAKPASAEAQEARVRELVSAAPKLIPILGHRYLLAEPCKAGNPVLSIYQSDMVVYGDNLHNFFLKEFGGLFGVKSFEIPRLALVDFSAYELIPFWGEFL
>CP035758.1|QBD74779.1|375285_375753_+|NUDIX-domain-containing-protein
MYPRSSVAAVIIHDEKLLVVKKRDVKGIVYSFPTGGQEPGETLTQAVQREVLEEVGCTVQVGPLLWVREYIGKHHENADLEGDVHVVCHLFHCTINELSGALQGSSPDSTQEGVEWLPLEQLATIRFYPQALIPFLFEQAHAIPPIASLYVGDVN
>CP035758.1|QBD74778.1|373914_374724_-|alpha/beta-hydrolase
MEEKNTPLLVDIGGRLLAVRTEGEGVPTVVLEMGLGAAGSIYDAIAKQIAYFTRAVWYDRAGLGLSDPASTPRTIQDLARDLHFLLQKTGIPGPYVLAGHSLGGPVVRFYRERYPDEVAALILIDSSHEDQRERCLALLPPKSSDEAGNLAQLRLALERQWKDPNANEEKIDNLANSQLLRTCQSLDDLPVTVVSRGRSAQDPTKYPPGLVEAMEQAWRQMQCELARLSPKTQHVIATRSGHMINKDEPEVIVEAIRQMVIQVREQCKL
>CP035758.1|QBD74777.1|372984_373836_+|SMP-30/gluconolactonase/LRE-family-protein
MSHEPKPQILLTNLSFGESPRWHAGKLWVSDWGTRELLTVSQDGKREVAVKLGFPSFQPICMDWLPDGRLLIVSSAEGRLLCRQADGSLTTYAELSQFSSQPWNEIVVDSRGNAYINGEVLLLITPDGTVRQVANNLAFPNGMAITPDNTTLILAESYARQLTAFDIASDGSLSQRRIWAELGDGTPDGICLDAEGAVWYADVPNKRCVRVREGGEVLQTITLDRGCFACMLGGDARKTLFLVTREWRGWEAEMQAASEKAADEIRTGQLLAVEVQVPGAGQP
>CP035758.1|QBD74776.1|371908_372742_+|alpha/beta-hydrolase
MSTKQKHYKLPNGDVQLAVSETGQGQTLLFFNGGGATQVAWKRLISELQGQYRLVTFDFRNHGKSTTSRNTSLESFMTDAETIMNEMAGDRPILIGWSLGADLAVWYAASHPGKVAGLFLIDGAVPVNLVSDPEDVRRRLDTPMMRIGPLLLYLTGMGYRLTPDQFATLTIELNKRREQLLAAYEQLDCPVELVLATKSAGEKGERAERTNALWRAGGEQLAQAFPELSLSMVDNTHLLPIKEPAALAQLLEAFVQRCQSGAQSDTPSDGSLSTSNS
>CP035758.1|QBD74788.1|385061_386246_-|Gfo/Idh/MocA-family-oxidoreductase
MIAPRCSLLTISGGISALSNPTDANHKIKVAFLGIRHPHVFVRVELAQRDAELKIVGFYEEDGEIAERFAAQTTLQRFASAEALLSTKPDLVIIEALDTQVPALALLAAPHTRALLLEKPGAPDRSSMDALVEQLAQYDIEVEVSYQLHYSESVAMCREILQAGALGQITQARFHAGCPIGCGAELWQSVPGDLGGVVYTEACHILELMVDMLGMPGRIFAAVQKLPPGASVVSDVVKPDLFAGTGLPTTLRVGELMYEDVGAAIFSYPDKLVTLDVTAWEATDWVQGWRMEFYGTNGSLSAIPNPPTVQLFLPAPVAGYRAGDLLFQGQGPRGPENSLVPDQTYERQFERLITVLRERQPASQEGLRRGQDVVHILDAIYRSAREGRAIDYPG
>CP035758.1|QBD83345.1|386496_386907_+|OsmC-family-peroxiredoxin
MSVRATNTGESSFTIETGSGHSITLSGMPENQGPRPMEMLLVGLAGCAGVGILSILRKMRQNVTNYEVRVRGERADTDPKVFTTIYVEHIFTGSNLQAESIQRAIDLDTTDYCGANVMLSTSATIKHSFQIKEASA
>CP035758.1|QBD74789.1|387094_388276_-|hypothetical-protein
METRISLWAYLWDINAVGPQVALQEMKETGINTVSVALSYHAGHFLEPRNPLHKVYFPEDGTIYFQPEQDYGRIKPEVASFVSEQNLPGSVTAKALDAGLQVASWTVCLHNTRIGMLYPDVTTQNAFGDKNIYNLCPSHPAVQQYIGALIRDISSLPGVSSIELEALNYMGFEHEFHHEKDAVGLTALDNFLFSVCFCPSCMQGAQKQGIDAEAARQYVRETLSKNLEREIPLQSESQDFLAQGQAYFAKHRAFHSYLSWRSEPVTALLQRVKAAVAPGVKLFFLDLMGPHSDWMFGVDFASLGENCDGIVVCCYGLEASEVDAAISEVRRHLSETEIVAGFRLYYPEITGPAALKERVLAARQAGANGMALYNYGLVPRARLRWAQDACALW
>CP035758.1|QBD74790.1|388284_389865_-|hypothetical-protein
MIALGIDVGTSSVKVLALDAQGRVLGTASAGYIFRHDPLQGSFEIDAEEWWQATCKATRECLAACRISSAEIALVGLTGNMSSVVLVDDSGLPVRPALLLADARGSAECGEVAPELLAEIRETTHNAPDNTAFVITKLLWLQRHAAPDIARAHAWLAAKDYVRLRLTGKPGVELTDAGNWLLVDTQACTWRWPWIEALGLPGRLFPHLHASADIVGGITPQAALMTGLREGTPVSAGAADMATAAIGSGTLRPGQLGVSMGTSTTLIAPLGSAAFPQFWRDKLTCHPFPHPFGNYALGSLLTGGLALNWLRSLQEAPQHKVELPQHPATSVIPADQEPGANKSGTGLLELSEAQALSPESLSPLVFLPYLAGYGTPSFDPQLRGTLFGLSPQSSLQDIYVALFEAVAFDIAAVIELLGQIPLDKIRVSSGGANLGIWLQIITDVAGIPVEVTAEKNVSALGAALLAACSSGMFAQLEEAVERVVAIQQVYRPRAHFAQAWKRRRQRYGRALALARDYYHFSEEERR
>CP035758.1|QBD74791.1|389861_390680_-|GntR-family-transcriptional-regulator
MQKLDPSVLGPIDRQSFTPLYRQIADEIESHLQALPVGTMLPSETEIVAHYNVSRGVAVQALKELLHRNVIVRMQGSGTFKASVMPARFTRSLNEVKLPSFSEDLKRTGHKTSERVYECELVAGTKAVRQALKLSEGGQAWKLARTILADQEPVVYLISYLSAEIYSEIDTTKVARQSLYGYLEASYGAGYRPAWAEEEYSAIVAPPWLRQFLEVDENSPLLTSTRIAYLADGRPSEYVQSYMRGELYHVKVTVLPALEPTNIGKLELEMRR
>CP035758.1|QBD74792.1|390679_391483_-|creatininase-family-protein
MQSLFCQIVKNFCQYFLMKGNRLMPEWAKLYWTDVAQAVETSRIALLPLGAIEEHGPHMNLGSDWYAVESLTARLAEAANLLVLPALPYGQVWSLSRFPGSLSISDQTLVNIIVEIAAGLAQVGIKGLILMSGHLGNMSALKTAARRLLESYDLPTLFLFYPGLEKICKQVSETERSRATIIHADEIETSILLALAPECVDMSRAQREYPHYPEDFDYSPLYWDEVSVSGVFGDPTAANQEKGKIIVEYVLQQTLRIIQAWRERGGF
>CP035758.1|QBD74793.1|391636_392389_-|HD-domain-containing-protein
MEIPFCLETELEKQICADPDWCRGARWGKVRPGHREGKVINHIADVLKNVDRHATNAEERRILRLVALLHDTFKYQCTPDEPDHEIHACNFARRYLNEQAIFEIVELHDKAGDAWRKGTHHAQWPIAERMIDTLIERLDKMSLLNLYLQFMRCDTQTSSKNQAPLRWFEDHLRQRGYAVLPEPAPYRRPFKELPLRILLWTQRRLKRLLRLRATKSASQLMLPAPQNYHEQSLEQGGHIVLYPRELCRPK
>CP035758.1|QBD74794.1|393148_394888_+|peptide-ABC-transporter-substrate-binding-protein
MSIRRGLTGRFGFIGLVMLTLLLAACGGGTPQTNSSNNNGMSNNQTLIYSTQGQLDVTDFDPAYSGGPIGPNFYFTGLVELNEKNELIDQLAQSHELASDGVTWTFHLKPNLTFSDGSPLTSEDVIYCIERALKPETKSGNGPAYLGAIKDAIKLNSGKIKTIIGDSLLAPDPRTVVIVTEQKAAYFLQTLTYNTSFTVSKKYAEKYGNKLSDHLTDPIAAGPFVISQVQDQKIIFTPNEHYYGPKPKLKKIIMAFYPDVDASYKAYLVGQVSLAKVPSVQRQSAKALPGNQYHQTPILGTSYYTMNYLTKPFDNIKIRQAFALAINKDQVAKSVFNDTVVPTNHIIPSGMPGYNPDLKGPSGISNTSGDPEMAKKLFDEGLKEEGLTRQSLPPLTLTIYNVSADDGREASVVQQMWQQVLGVSVKVDSMESNAYRKAVDATAHNPKGLIMWGAYWKADYPDPQNWMSTLFDKDAYFNSENYSVNQSSNVADQQKAVDLMKQADANMDQTARMKQYNQAEQQVVNDVAWIPMYQMENLKVVKPCVQNYPYDAQFVPAPDSWANIYISNNPICTSANAAG
>CP035758.1|QBD74795.1|395000_395762_-|hypothetical-protein
MSLRILSYNILEGGEDRLSHIAHTIERQRPDVVALLEANSRTNAETLAQQLGMSLSFGEGNSEYYVAWLSRLPVVRTENYRRSVFSKTLLKIEVPWENTIVALFATHLSAGRKQENEQDRVAEMREILSILQQHKQQPHVLVGDMNSLCPGDEIDIATYLATATEKGEEKMRPDEFVREVVALVLQAGYTDCYRKLHPQERGYTYKLPSRPSLRLDYIFASPDLTAHLTACDIVADDEARSASDHLPIWAQFS
>CP035758.1|QBD74796.1|396278_396881_+|TetR/AcrR-family-transcriptional-regulator
MPRSEAANQRIREERREHILDASALVFARKGLAATKIADIAEASNISQGLIYRYFVNKEEIFTALIERALDATASIAQAALKQSGSPLAKLHWLLENFFSGMWEQPEYAQMIMQALSSDTTPEEVNMLVAKHISPIIKAFYHLIVEGQACGEIIADDASMLTFMVLSCLQGTIRGMLHQELLPKPVGPPNPEIIIRMLKA

Crispr_ID: CP035758_3

• CRISPR_ID: CP035758_3
• CRISPR_location: 850736-850877
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of CP035758_3

Consensus_repeat	Method
TTTAGAGAGTCAAAACTATATATT	PILER-CR

spacers of CP035758_3

>3.1|850760|33|CP035758|PILER-CR
CAGATTTTTCTACGATTTGCAGGATATCAAATT
>3.2|850817|43|CP035758|PILER-CR
ACCTGGGGATAACTCTAAATTTAAGAGGCTGATGAGTACAAAG

CRISPR arrays and Neighbor proteins around CP035758_3

CRISPR arrays

The CRISPR arrays of CP035758_3

>merge|CP035758|3|850736-850877|PILER-CR
TTTAGAGAGTCAAAACTACAGATTTTTCTACGATTTGCAGGATATCAAATTAAAAGAGAGTCAAAACTATATATTACCTGGGGATAACTCTAAATTTAAGAGGCTGATGAGTACAAAGTTTGGAGAGTCAAAGCTATATATT

>CP035758|3|1|850736-850877|PILER-CR
TTTAGAGAGTCAAAACTACAGATT	TTTCTACGATTTGCAGGATATCAAATTAAAAGA
GAGTCAAAACTATATATTACCTGG	GGATAACTCTAAATTTAAGAGGCTGATGAGTACAAAGTTTGGA
GAGTCAAAGCTATATATT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD75167.1|853749_853983_-|WGR-domain-containing-protein	unknown	unknown	gnl|CDD|153425
CP035758.1|QBD75161.1|847406_847931_-|MarR-family-transcriptional-regulator	unknown	unknown	unknown
CP035758.1|QBD75173.1|860379_860664_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	unknown	unknown	gnl|CDD|368240
CP035758.1|QBD75159.1|843634_846610_-|Tn3-family-transposase	unknown	unknown	gnl|CDD|376561
CP035758.1|QBD75155.1|838845_839166_-|EthD-family-reductase	unknown	unknown	gnl|CDD|131173
CP035758.1|QBD75157.1|841833_842712_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75168.1|854788_855289_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75172.1|859243_859906_-|DNA-methylase	unknown	unknown	gnl|CDD|184255
CP035758.1|QBD75156.1|839419_840496_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|236196
CP035758.1|QBD75158.1|842799_843078_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75163.1|848494_849433_-|hypothetical-protein	unknown	unknown	gnl|CDD|227316
CP035758.1|QBD75169.1|855748_857260_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75160.1|846796_847384_+|recombinase-family-protein	unknown	unknown	gnl|CDD|239737
CP035758.1|QBD75171.1|858705_859146_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75166.1|852411_853200_-|ParA-family-protein	unknown	unknown	gnl|CDD|224113
CP035758.1|QBD75154.1|838445_838757_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75164.1|850888_851962_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75170.1|857667_858675_-|hypothetical-protein	unknown	unknown	gnl|CDD|370551
CP035758.1|QBD75162.1|847955_848381_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75165.1|852074_852410_-|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD75156.1|839419_840496_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|236196	PRK08241, PRK08241, RNA polymerase subunit sigma-70.	8.64551e-133
CP035758.1|QBD75167.1|853749_853983_-|WGR-domain-containing-protein	gnl|CDD|153425	cd07996, WGR_MMR_like, WGR domain of molybdate metabolism regulator and related proteins. The WGR domain is found in the putative Escherichia coli molybdate metabolism regulator and related bacterial proteins, as well as in various other bacterial proteins of unknown function. It has been called WGR after the most conserved central motif of the domain. The domain appears to occur in single-domain proteins and in a variety of domain architectures, together with ATP-dependent DNA ligase domains, WD40 repeats, leucine-rich repeats, and other domains. It has been proposed to function as a nucleic acid binding domain.	5.22494e-26
CP035758.1|QBD75163.1|848494_849433_-|hypothetical-protein	gnl|CDD|227316	COG4983, COG4983, Uncharacterized conserved protein [Function unknown].	1.8495e-37
CP035758.1|QBD75160.1|846796_847384_+|recombinase-family-protein	gnl|CDD|239737	cd03768, SR_ResInv, Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.	4.63233e-56
CP035758.1|QBD75173.1|860379_860664_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin	gnl|CDD|368240	pfam05016, ParE_toxin, ParE toxin of type II toxin-antitoxin system, parDE. ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.	5.57229e-16
CP035758.1|QBD75159.1|843634_846610_-|Tn3-family-transposase	gnl|CDD|376561	pfam01526, DDE_Tnp_Tn3, Tn3 transposase DDE domain. This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.	3.84424e-160
CP035758.1|QBD75155.1|838845_839166_-|EthD-family-reductase	gnl|CDD|131173	TIGR02118, TIGR02118, conserved hypothetical protein. This model represents a small family of proteins of unknown function, each about 105 amino acids in length. Conserved sites in the multiple alignment include a pair of aromatic residues, a histidine, and an aspartate. [Hypothetical proteins, Conserved].	1.52225e-23
CP035758.1|QBD75172.1|859243_859906_-|DNA-methylase	gnl|CDD|184255	PRK13699, PRK13699, putative methylase; Provisional.	8.15152e-98
CP035758.1|QBD75166.1|852411_853200_-|ParA-family-protein	gnl|CDD|224113	COG1192, Soj, ATPases involved in chromosome partitioning [Cell division and chromosome partitioning].	3.41473e-43
CP035758.1|QBD75170.1|857667_858675_-|hypothetical-protein	gnl|CDD|370551	pfam09538, FYDLN_acid, Protein of unknown function (FYDLN_acid). Members of this family are bacterial proteins with a conserved motif [KR]FYDLN, sometimes flanked by a pair of CXXC motifs, followed by a long region of low complexity sequence in which roughly half the residues are Asp and Glu, including multiple runs of five or more acidic residues. The function of members of this family is unknown.	0.0016708

Protein sequences

>CP035758.1|QBD75163.1|848494_849433_-|hypothetical-protein
MVLADGGIAERIHSGNVPELLKSIPQWVLWKYQHIPGKDKPKKPPFQPGGRAASVDDPQGWCSYTQAMAALDTGHYQGVGFMLENSGIVVIDLDNCLRDIDGVRRITRTARQVFDLAQSYTEVSPSGKGLHIFLRGSLPAENGHPVLGMKSDKGEMYAAKRYITITGERVGEQREIRTDQEAIHQIYALLKPPRQQPRPEPETIRRYQPITRDDQALLKKAGEARNGAKFTRLCSGDITGYRSRSEAQLALIAMLVYWTNGDEGQVERLFKASNMYRQDEELQQKWDTVHRSDGATYGEMTIEKATQTSRQL
>CP035758.1|QBD75162.1|847955_848381_-|hypothetical-protein
MKTGPSPQWLKITEMPRVAWMIDGMLEAAEEVYGSLQQAREKPHVMDDLAINRVYEVHGSQLEDLWLYEEQLRRFEKEMTSADQGKEIDRLTAQLVKLRGVLAASLKLADEIREGTLNRIMEMDDGQLAIEVMQGKRKPPV
>CP035758.1|QBD75161.1|847406_847931_-|MarR-family-transcriptional-regulator
MTILAEKIISTLQQFSGLTDRELTNKILGKNSLQQPVNSVCRLLAQRKVVNRIHRDDGKIGNYLLDTAPLRIQPNSPNAAFDVHSEDAVKQHIANWLAADGWNYDVKWGKTRGIDIHASKGNARWIIEVKGIGSYPSMRVNYFLGALAELLQRMDDPKGVMAEYSQNRTLRTRI
>CP035758.1|QBD75160.1|846796_847384_+|recombinase-family-protein
MNKQVGYARVSSHAQDLQLQIDALRKAGCAEEHIFIDKVSGARTERPGLNASLELLQPGDTLTVWRLDRLGRSMPHLVALVEGLLKRKIGFRSLCDGSIDTTTASGELMFNIFSSLAQFERRLIQERTKAGLAAARARGRKGGRKQTISDDPRVKTAKRMHKDHGMSIAHICQILKISRATFYRYIALPEEKSAA
>CP035758.1|QBD75159.1|843634_846610_-|Tn3-family-transposase
MKKHEILSAQSRTALFNPPTDPATIIKYYSLSEDNMALIRKRRRPENRLGFAVHMAYMRYPGRVLGQDETPPEELLGFIAEQLAIAPKVFQRYAQRDETRREHSSELLSYLGMRSFQASDLRALSKAAVTEANGTEKGEAIVAAMLTWLQQKRILLPATAMIERIALAARATARQQAYKSLTAGLDAACKIALEALLIVKEEEKTSPFAWLRQWQEMPKLKNLTGILERLNTVRRLAVAPDREQRIHRARYMAIVREVAIMDAQHLSRQDEARRIASLIVFARETETLLIDAALAMAGKMIGTVFRSAEKSHKEHLSERAKVLKKTSKTLLKLAKSVLAAHDTGGDTDSAIEKDIGWDRLAEVVKAAEAAIQATRDDSLEDVLERHATIRRLAPLLLEHFTFCAATPGDPLLAALEMLRGMYATHRRVAKENLPVAFLQPKWKKLMWAAEVKKKRQVWEVAVMVELRDRLAGSIWVEGSRAFRPFDEYLLPKTVYIEKKEKGDLNLGIPTRFEDWRDQRMEALETRMKTVADLAESGQLPDAVLNEEGLSISPIKRSTPPEAEELSYRLYRMLPRVRITDLLMEVNHWTGFADCFGHLRNGEPPSDMLALMSVLLADATNLGLSRMARSSGELTHAKLVWIAEWYVRDETYKPATALLVDALHAEPLAAFWGSGQISSSDGQFFLSGGRGKDRAGHNAKHGIDPGLLLYGHQSDMFGGFGLQPIAPSIGEAPYVLDAIMHHETTLKIIEHFTDTAGAVDHIFALFHLLGIRFSPRIRDLAERKLYRMPESTHYEVFSPLMGGTVDLRHIEATWEETLHFAASIKAGSCAPSVLLRKLRAYPRQHSLAKAQKEIGKIERSCFTLDWISDPELRKRSHGTLNKGESRHSLARSVFFHRHGEFHDRTLENQRYRASGLNLVVSAIILWNAVYLNRAITELRNSGVIIPDELLPHTSPLGWEHISLNGDYIWPKEPLQAPFRPLRNPNAEWFKRE
>CP035758.1|QBD75158.1|842799_843078_-|hypothetical-protein
MLDNSMFSFVEPIIEPTEDSFSEFVTQLDAFFDFMEEQGKPVPVPRPLNEETYKDMWMLRYQQHLGHITFLELLDRYEEMLGISVPKGSSGT
>CP035758.1|QBD75157.1|841833_842712_+|hypothetical-protein
MIRESWKTIALARAEIITDLWEVAKAYAGRAAEWVLFLCMVVNIVEMLPGVNIAGWILNTVLGVQVVMLDIGGMSLGTMASHIREQGNAEAAKKADVTSKFLIGLMVVTLLLVSIGMLFPAIKLYTDMGEKGLILVRVVMTVIYGHVIHSLRSTSKTQPVPATPPAAVPDSAELEAIIRGILVPVLAQYRTDARADIAEQVKQALSLVAIAGEKEMPSVSSSDRKRLSPAPTSLASVRRMEEGYASRETRLSDAHQALLQEGIRPTGDTLSRRARCNRAVALNWLKAQKIAG
>CP035758.1|QBD75156.1|839419_840496_+|sigma-70-family-RNA-polymerase-sigma-factor
MYSVTGKHRQADCMNEAPITDQASLDQSSCGLLFESYRHELLLHCYRLLGSLHDAEDAVQETMLRAWRHFDTFTQKGPGSLRAWLYKIATNTSLDLLKKRLPRTLPTAATPPWDPDRPVAKREAEELWLEPFPNSWLAEATENPEARYTRGESVSLAFLTALQLLPPRQRAILLLSDVLDWRAVEIAQLLEISGGAVNSALHRARVTLEKNYPSLQREMAQVDRVDAATKMLLTRYLQAWETGDVNGLVALLKEDATLSMPPIPSWYQGREAIRTFFRAVLFPSGVQNRWRLSPTRANGQPAFVVYRADEATRAYRAFALQVVTLDATLSDLPQVASVTAFLEPELVTSFGFPLQLCQ
>CP035758.1|QBD75155.1|838845_839166_-|EthD-family-reductase
MVKFLVLWNTPADPVAFERHYREVHIPLVRQLPSLRRYTAGCHATALRGEPYYWIAEAEWDTMEALQKAFQSPQGQAVSQDVANLAHHAQVRSMVYEVEELESAHD
>CP035758.1|QBD75154.1|838445_838757_-|hypothetical-protein
MIITHIQYTVRAEYAAENQKYIRRILEDLRTLGRTDIGSSIFVKEDGKTFLHFLFCEHEEAEQTFFQLGSLQAWRTALVESSPEVPLTAPTRLSVVGSTAKLL
>CP035758.1|QBD75164.1|850888_851962_-|hypothetical-protein
MTTSKSKKKLDEAPKVLAVAVSKKLENYDHSKPQQLTLFEMLLPQDKDYSNTIELYDFIPKYTYGKVERIADKFLDLLEREFECRTHKYKVQISPAVIKDKDGIARYYYPSKREEIIEDALRKFMAEGQGYFLDGMAGVTFTLYQLQEELKKNDHSYSIQQLKDALMICARTNLTVTNEEGKAIVISNIFETVGLQTREDWKTKGKSTKAFVRFNSLVTKSIEDLTFRQINYEKVMSYRSVIARQLHKRMSHHFTQASIHIPYTISLTTIIRDFGLTKYAKLSGNLRDVEIALEEMKEKKILIIYHIDKVLESSKRSKLIDAMFSLHPNPHFVSDSIKANTRTKEIKHKIYSSDSPK
>CP035758.1|QBD75165.1|852074_852410_-|hypothetical-protein
MPAQKTAPQTRQRPKIKSSFGAVLSTQQQVIEQDTNTLVSQLPDIPVSQDTAIPVSQHKKAKEQRTKKGVYLKPSTAKWLDIQAATEGREISEITEEALILLQKAKSENQC
>CP035758.1|QBD75166.1|852411_853200_-|ParA-family-protein
MWHIQQQGGVGKTTTTISLGTAAARRGLKTLLVDMDGQSSLTEYFIDLETKEAINPSMAEMLLDKRGQVRIEPVQLMENLYILPANTKLAEAELVIASYNNPQALLRQRLRLYDGEFDICLMDSPPAIGLLTRNVLGASDFVIVPMATEEMGIRTLPQTLAQIDEIKESEVNTAIKLWGIIATMYDIREGEDRRILEILRSDYAQELYSEVLPRRTGYKKAVGNRADISDVDKDLGKYWSRLARTLFKDTLTKNRLQTKEIA
>CP035758.1|QBD75167.1|853749_853983_-|WGR-domain-containing-protein
MAPAPVTLYHIDPARNMKRFYRLDLQPDLFGNQCLIREWGRIGRPGQVRSIPYPTSDEAQVAFQKQRATKERRGYIT
>CP035758.1|QBD75168.1|854788_855289_-|hypothetical-protein
MGTRSNIGIQNLDGSYDVIYCHWDGYPSHNGKILYEHYQDIEKIKQLLALGDLSSLGEEIGEKHPFDTIHMTEAQRQAHEKKYGKICTAYARDRNETDTEARHYKNYDELCAMLEEAWTEWVYFYRMEDGKWYYTNNPSPTWFKCCGTEQMQTSLLTPEAWQNKVI
>CP035758.1|QBD75169.1|855748_857260_-|hypothetical-protein
MINNAYGGWTPLRNALRKLDLNDTLGVIKVYSAFKAVRTPSPFPADMEVHRAVYSDERLILPWEMEILAREAIIVCNSQPSTRYTGRKWDTFASLINKLRELENYISQYLVDDKKILQEVTVRIPHQQFKYQTEHPSKAAMVRYSHIFGHLSVEPIVKAKTGLLPKQLFTIGAILWIKYVTQYLGVHYPLDDLSLPGITQADYDKFIQLYSLPMKELKQRLTAERKLDNTFMYQFHTLQSYPLILTELNNRASHICPIPTLLFWRISSGLFYDLVKEPGFDQAFGTAFQDYVGDMLEKTLIGTSSTVYPEEPDTRPKRADWIIDQPTSFMLVECKTKRMTIGARTNIQDDMELHAQLEVIGKAAVQSYQALEAYKNGKYRPQQYPYNPMKRPFICVVTLENWRLMGPELERLREIVRNKLVEAGLASTLIEQAPLILCAVNEMEEFAYLLKTKSLEDLVLDYWNDQEKSSWSFIGYLSDRFKHELESYQHVFAGEFEIIFTVK
>CP035758.1|QBD75170.1|857667_858675_-|hypothetical-protein
MFDNILRELKKIEAGSQITISMPTDNDGYFDRRCPSEACQADFKVLMEDWKQKVSDAQVFCPICREEAKATEWSTSEQQEYIRQAGINYIQGKIGQALSQDARDFNRRQRPGFINMSMSYKPGAPTLIIPISAAEELRQKFTCEQCGCRYSSLGAAFFCPACGHNSAESTFSQTIEAVQKSLSALLAIREAVQAVADADAAKNTVREILENNMGRLVGAFQRLAEALFDRTPAAPTTRRRKNVFQNLSEGSALWNAATGKGYADLLTPAEMADLLRLFQQRHLFAHCEGIVDQDYITKSGDTTYVIGQRLVIREGAVSRLAELVTKLADELRKLV
>CP035758.1|QBD75171.1|858705_859146_-|hypothetical-protein
MIQRIPQRGKTDCTICVVAMVMGHQYSYERVLQDSEKYPKISEEGKFYGWWETYLRDEGFLIEYRPFMELYSLPQYRGSVVGLLMFDVPHIKYSHIVAVDELGIIDPADNAPPHVDIGEYILQRRSQGAVFHNEFLAVADSKTVTY
>CP035758.1|QBD75172.1|859243_859906_-|DNA-methylase
MTSAPLTFETINSNTIIHGDCLRVMPQISAGSVDFILTDPPYITRYQDRSGRSIQNDDNDAWLKPAFAEMYRVLARNSFCVSFYGWPQADRFMNAFRAAGFRIVGHLVFPKRYTSGSRHLRYQHECAYLLAKGYPNEPEYPIGDVIDFVYSGNRLHPTEKPLSALLPLVETFSTYDGLVLDPFAGSGSTLHAAKSLGRRYLGIELDTRYHALAANRLCAV
>CP035758.1|QBD75173.1|860379_860664_-|type-II-toxin-antitoxin-system-RelE/ParE-family-toxin
MFCIFTAQAETDLESIADYIALDNPARALSFVQEIRERCRHIAHAPRGYPLAPEYGEDIRKLPFGNYLILYTLQADDIVILHIPHSARDLPVHS

Crispr_ID: CP035758_4

• CRISPR_ID: CP035758_4
• CRISPR_location: 1195165-1195254
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP035758_4

Consensus_repeat	Method
TATCTGGCCTTCTTGCTTGGCCAGAGC	CRISPRCasFinder

spacers of CP035758_4

>4.1|1195192|36|CP035758|CRISPRCasFinder
TCTTAGCGCTGAGGCAGAAGCAGCGATCATAAAGAC

CRISPR arrays and Neighbor proteins around CP035758_4

CRISPR arrays

The CRISPR arrays of CP035758_4

>merge|CP035758|4|1195165-1195254|CRISPRCasFinder
TATCTGGCCTTCTTGCTTGGCCAGAGCTCTTAGCGCTGAGGCAGAAGCAGCGATCATAAAGACTATCTGGCCTTCTTGCTTGGCCAGAGC

>CP035758|4|3|1195165-1195254|CRISPRCasFinder
TATCTGGCCTTCTTGCTTGGCCAGAGC	TCTTAGCGCTGAGGCAGAAGCAGCGATCATAAAGAC
TATCTGGCCTTCTTGCTTGGCCAGAGC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD75494.1|1204614_1207335_-|hypothetical-protein	unknown	unknown	gnl|CDD|225461
CP035758.1|QBD75478.1|1187134_1187845_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|378924
CP035758.1|QBD75475.1|1184046_1184991_-|LLM-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|200301
CP035758.1|QBD75483.1|1193583_1194369_+|hypothetical-protein	unknown	unknown	gnl|CDD|350158
CP035758.1|QBD75482.1|1191797_1192874_-|iron-permease	unknown	unknown	gnl|CDD|272930
CP035758.1|QBD75490.1|1200708_1200954_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75489.1|1200152_1200383_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75491.1|1201099_1201339_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75493.1|1202725_1204603_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
CP035758.1|QBD75492.1|1201526_1202576_+|signal-peptidase-I	unknown	unknown	gnl|CDD|274044
CP035758.1|QBD75486.1|1198488_1199028_+|hypothetical-protein	unknown	unknown	gnl|CDD|284659
CP035758.1|QBD75485.1|1195405_1198285_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|276809
CP035758.1|QBD75479.1|1188143_1189562_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
CP035758.1|QBD75488.1|1199757_1200015_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75474.1|1180461_1183704_+|peptidase	unknown	unknown	gnl|CDD|227282
CP035758.1|QBD75476.1|1185089_1185422_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75487.1|1199079_1199661_+|TlpA-family-protein-disulfide-reductase	unknown	unknown	gnl|CDD|131709
CP035758.1|QBD75480.1|1189595_1190255_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
CP035758.1|QBD75477.1|1186053_1186986_+|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133382
CP035758.1|QBD75481.1|1190631_1191702_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD75494.1|1204614_1207335_-|hypothetical-protein	gnl|CDD|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	2.25046e-123
CP035758.1|QBD75478.1|1187134_1187845_+|alpha/beta-hydrolase	gnl|CDD|378924	pfam12697, Abhydrolase_6, Alpha/beta hydrolase family. This family contains alpha/beta hydrolase enzymes of diverse specificity.	0.000112615
CP035758.1|QBD75475.1|1184046_1184991_-|LLM-class-F420-dependent-oxidoreductase	gnl|CDD|200301	TIGR03621, F420_MSMEG_2516, probable F420-dependent oxidoreductase, MSMEG_2516 family. Coenzyme F420 is produced by methanogenic archaea, a number of the Actinomycetes (including Mycobacterium tuberculosis), and rare members of other lineages. The resulting information-rich phylogenetic profile identifies candidate F420-dependent oxidoreductases within the family of luciferase-like enzymes (pfam00296), where the species range for the subfamily encompasses many F420-positive genomes without straying beyond. This family is uncharacterized, and named for member MSMEG_2516 from Mycobacterium smegmatis. [Unknown function, Enzymes of unknown specificity].	1.50351e-113
CP035758.1|QBD75483.1|1193583_1194369_+|hypothetical-protein	gnl|CDD|350158	cd09007, NP-I_spr0068, uncharacterized subfamily of the nucleoside phosphorylase-I family. This subfamily is composed of uncharacterized members including Streptococcus pneumoniae hypothetical protein spr0068. The nucleoside phosphorylase-I (NP-I) family members accept a range of purine nucleosides as well as the pyrimidine nucleoside uridine. The NP-1 family includes phosphorolytic nucleosidases such as purine nucleoside phosphorylase (PNP, EC. 2.4.2.1), uridine phosphorylase (UP, EC 2.4.2.3), and 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP, EC 2.4.2.28), and hydrolytic nucleosidases such as AMP nucleosidase (AMN, EC 3.2.2.4) and 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase (MTAN, EC 3.2.2.16). Members of the NP-I family display different physiologically relevant quaternary structures: hexameric (trimer-of-dimers arrangement of Shewanella oneidensis MR-1 UP); homotrimeric (human PNP and Escherichia coli PNPII or XapA); hexameric (with some evidence for co-existence of a trimeric form) such as E. coli PNPI (DeoD); or homodimeric such as human and Trypanosoma brucei UP. The NP-I family is distinct from nucleoside phosphorylase-II, which belongs to a different structural family.	1.52134e-38
CP035758.1|QBD75482.1|1191797_1192874_-|iron-permease	gnl|CDD|272930	TIGR00145, Uncharacterized_protein_slr0964, FTR1 family protein. A characterized member from yeast acts as oxidase-coupled high affinity iron transporter. Note that the apparent member from E. coli K12-MG1655 has a frameshift by homology with member sequences from other species. [Unknown function, General].	4.41552e-13
CP035758.1|QBD75493.1|1202725_1204603_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	9.55334e-100
CP035758.1|QBD75492.1|1201526_1202576_+|signal-peptidase-I	gnl|CDD|274044	TIGR02227, Inactive_signal_peptidase_IA., signal peptidase I, bacterial type. This model represents signal peptidase I from most bacteria. Eukaryotic sequences are likely organellar. Several bacteria have multiple paralogs, but these represent isozymes of signal peptidase I. Virtually all known bacteria may be presumed to A related model finds a simlar protein in many archaea and a few bacteria, as well as a microsomal (endoplasmic reticulum) protein in eukaryotes. [Protein fate, Protein and peptide secretion and trafficking].	5.60203e-26
CP035758.1|QBD75485.1|1195405_1198285_-|tetratricopeptide-repeat-protein	gnl|CDD|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	2.12614e-14
CP035758.1|QBD75479.1|1188143_1189562_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.40683e-50
CP035758.1|QBD75474.1|1180461_1183704_+|peptidase	gnl|CDD|227282	COG4946, COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown].	4.46936e-148
CP035758.1|QBD75487.1|1199079_1199661_+|TlpA-family-protein-disulfide-reductase	gnl|CDD|131709	TIGR02661, Methylamine_utilization_protein_MauD, methylamine dehydrogenase accessory protein MauD. This protein, MauD, appears critical to proper formation of the small subunit of methylamine dehydrogenase, which has both an unusual tryptophan tryptophylquinone cofactor and multiple disulfide bonds. MauD shares sequence similarity, including a CPxC motif, with a number of thiol:disulfide interchange proteins. In MauD mutants, the small subunit apparently does not form properly and is rapidly degraded. [Protein fate, Protein folding and stabilization, Energy metabolism, Amino acids and amines].	3.2274e-14
CP035758.1|QBD75480.1|1189595_1190255_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	1.42224e-75
CP035758.1|QBD75477.1|1186053_1186986_+|MerR-family-transcriptional-regulator	gnl|CDD|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	6.61261e-39
CP035758.1|QBD75486.1|1198488_1199028_+|hypothetical-protein	gnl|CDD|284659	pfam07291, MauE, Methylamine utilisation protein MauE. This family consists of several bacterial methylamine utilisation MauE proteins. Synthesis of enzymes involved in methylamine oxidation via methylamine dehydrogenase (MADH) is encoded by genes present in the mau cluster. MauE and MauD are specifically involved in the processing, transport, and/or maturation of the beta-subunit and that the absence of each of these proteins leads to production of a non-functional beta-subunit which becomes rapidly degraded.	1.23582e-06

Protein sequences

>CP035758.1|QBD75483.1|1193583_1194369_+|hypothetical-protein
MNSIFTNFHLWREENCYVTAQEDLLHHHIDPQGIDLGTTCLVTFSSSLFERLLETYTVEQNDFWPYSTTPLRVCHTPTGKKFALHFPSYGGPRIANSLEQLAACGIRSVIGLGLGGTPQEHLNIGDILLLEGAMRGDGVSRYYAPMEYPAIADLALTARIRAQLEKRGEKFVSGLSFGTDALYREDKHLVAQLRTLGIISVELESSALLTIARRLGLACSWVGVVSDRLTPTLHEGNIHAEHIMDTLQRLARLLTELIDEL
>CP035758.1|QBD75482.1|1191797_1192874_-|iron-permease
MGISSLTPTHKRFYLFGTIGLICAAIVLAAFLTWQGVTAAGAPDPTVPHTSPLVAVLDIAALVFREGIECVVVLTAVTASLRGANRSYRGPIGMGVVVGMVATLITWFIAVGILSDLTTVVPALSLQAWTGLLAVIVLLVVMNWFFHKVYWTGWISFHNRKKKDLLELAKTPEGSKLAVLWGLGLLGFASFYREGFEVVLFLQSYRLQLGGTVVLYGALVGIIFSGILAFLSFVGNHRVPYKRMLVLTGVLLAMVLFIMVGEQVFEMEQAGWFSAMPISWLKWIPDWAGVWLSIYPDLPTIIAQVIAMALVFGSYFVSRYQAVFLPKKHGAAPYRWREAAPTVEVVGTSLAQGDAREG
>CP035758.1|QBD75481.1|1190631_1191702_+|hypothetical-protein
MLKIADEQATYSHGWLTRWPDWIAYATMVWSLLYALLGLFWTLGSKGFPFGAGDPNPEYSIFRGLPVEVGAPLIAALGCLCTVVALCLASGWGRGIVRGAGRAFAWVCALLLLLVIPDDRLLACVAHSFLLHFEMFNWTVINEFYCILGGILWIGTAVVAGREAHQACLYCGRRSDIAIGWTRPEQALKWGRWAVAVAVFVPLIYCTTRWAFALGIPLGVSAEFLSSMERENPGIWLGGASIATLGLGGALLTLGLIQRWGEVFPRWMIGLAGKRVPPLLAIIPATVVSIIVIEAGIGLIRHTINGTGVFSAQALAQDPSTVVPGLFWPLWGIALGLATLAYYYRRRGRCTHCGQE
>CP035758.1|QBD75480.1|1189595_1190255_+|response-regulator-transcription-factor
MQDTEVITILIVDDHAIVREGIRAFLDVQEDCSVVGEAESGAAALQMATELVPDVILMDLMMPGMDGVEAIRRLKQVSPHSQMIVLTSFHDDAHIFPALRAGALSYVLKDIPPDELVEVVRKAVRGESVLHPRVAARVVEELRGNRQATPNPFIELSERELEVLRLIASGRINAEIATQLSISEKTVKGHLSNILSKLHLMDRTQAAIFAWQQGLVNRD
>CP035758.1|QBD75479.1|1188143_1189562_+|sensor-histidine-kinase
MNSAIPLPWHFHRLRWKLTISYLLTSLIVLLVLELLVILIGTTATEAQRKTLLSGQAQRLVQAASLTAPAAGATRQQQFQALWDLLKDNAIDIQGYLAVISPDGQVIRMAGNAAPSTNAGLPGSVQQDIRQARSAQPAPSSQARVSFVADSAYAVAPFGESGIQHEVLLARVQSARSNGFPDLLVFFGASALIFFLGAGSVGLAFGFVTARGLVRRLQHIAVAVEGWSRGNFSIFVSDDSRDELGQLAHRLNLMAHQLQELLSTRQDLATLEERNRLARELHDSVKQQVFAVSLHISTTRAFMGRNEQAAQTHLLKAEGLIRQAQSELTTLIRELRPVALEGRSLAEALRDFTHSWQEQTGIAVELRLEGAQEVPLAIENAFFRIAQEGLANVARHSQATAATVHLSCKEMISLTISDNGRGFVLSERARQGFGLSSMRERAQALGAHFEVESTKNAGTTITVQCQQTQREA
>CP035758.1|QBD75478.1|1187134_1187845_+|alpha/beta-hydrolase
MDALIVLVHSPLVGPFSWSLVAEHLQNAGFSVLVPTLTDSGITPPAYWQQYAASLQQALAPIPQERPLILIGHSGAGYFLPVLAQATHHPIKAYIFADAGLPHPDQSQLDELQNKAPAIAQQLRQLLTQGASFPDWKFEEMGEIVPDENTRRLLLAEMQPRSFDYFAEVMPSVPGWPDAPCAYLLFTQSYLPYFEQAHSAGWPCRRLEAQHFHMLVDPVSVSTALVELIKQIDTQA
>CP035758.1|QBD75477.1|1186053_1186986_+|MerR-family-transcriptional-regulator
MTAFPLTLSLHEGVCSPCRASLRWRLMKEDTILKIGEFARINQISVATLRYYDQWDLLKPAVLDPDTGYRYYSLEQLPRLNRILALKELGFPLEQIAVLIEEDLSLEQLHGMFMLKQAQTQHMIDVEQARLSRIAARLRYIEEEGKMPAYEILLKQAESIRVASLREFMPLQDGFKQNYHKIATYLAQHHVQPGRPALLLLYARSEQGEGGLYIDAETAIPLSTELPGNAQIRVHTLQEQLLACTVHTGANLFIGQAYIALYSWLKDNSYQLVGPPRQVYHRWEKDLSPEQQIIELQFPVAKQASSPHES
>CP035758.1|QBD75476.1|1185089_1185422_-|hypothetical-protein
MMNALSSAQQNPQDNHSLAQSTRFSPLVTMVAWIAILLGSAASRVLWVEGLGYRASPHARRDLAYARRHRQDQERRLSMCCHDAFARCAITSSLAMPSEMASDPLRKSID
>CP035758.1|QBD75475.1|1184046_1184991_-|LLM-class-F420-dependent-oxidoreductase
MAIQHLFRFGVVVTTGAPSREQWISKARNIENLGYATLLVADHFSHAFSPLVALQAAADATTKLRVGSFVFDNDFRHPAVLAKEVATLDVLTDGRFDLGLGGGWNQEEYQQIGLPFEAAGVRLSRLEESIRIIKGLFADEPATFTGKHYTIHNLDGLPKPVQRPHPPLFIGGGGKRLLTLAAREAEIIGIHYKVNQDGTIDQEEYTSAGLARKVAWIRETAGERFNQLEFNLLIAHVEITENRQQAIERFLQEKRWQNLTIEQVIDMPYVLIGTEEQIIEELLMQREQSHISYFTVFDKHYETFAPIVERLAGR
>CP035758.1|QBD75474.1|1180461_1183704_+|peptidase
MGTTGYLRFPTIYRDQLVFTAEDDLWRVSINGGRAERLTAGVAAATRAHFSPDGQQIAFTGNDEGPDEVYVMPADGGPSRRLTYHAGHAEVVGWQPDGAQILYASSDGLPSLRWRMLSGISPQGGEPVRLPYGIANAIAFGPNGAVVLGRNMREPAFWKRYRGGTVGYLWIDAQGTGEFKRLLDLNSNIATPCWVGNRIFFLSDHEGISNVYSCLPSGEDLRRHSSQETFYARNLATDGHRCVYHAGGDLFVLDPASNQETRLKVDLAGSQAQRARQFVSAGKFMDSYALHPKGQAVALTTRGKAFSLSNWEGAGVQHGQKDGPRYRLIDWLADGKRLVAVSDAGDEPRLIVFRADGSTPDRTLGQLDIGHVTALRAAPVGDLVLLVNHRNEVLLVDLAAETLRVLDRSDYGRLEDGELVHGIAWSPDGRWVAYEQAIQAQQSIIKLCRLESGETYQVTDAVRRDTKPAFDPAGRYLYFLSARDFDPVPDAMHFEFSFPKGVRPYLITLRKNLRSPFQPESSLLTSEDEVKKAEKAGGNPSEPERVEIDLDGITDRIVAFPVPEGRYGRVIGARNGAFFTSLPIEGIRTDEMLGYKPKSNGSLEWYDFEKRKQEHIADEIGDIRGNADGTMVLCYSHDRLRVLKAGEKPPEGSSSSAADKPGRESGWLDLERLKVSIRPGAEWRQMFGEAWRLQREQFWVADLAGVDWQGVYARYSPLVERLTSRGELSDLLWEMQGELGSSHAYEFGGEYRSHPEYHQGFLGVDWRFDADEGVYRIAHIVRGDPWNAKETSPLLAPGVDAKVGDAVLAINGQHLTAEQGPQQPLVNQAETEVQILLQPTNGPARSVTVRALASEFGARYRDWVEANRRLVHEKTHGRVGYVHIPDMWADGYAEFHRYYLAEYDHEGLIVDVRWNGGGAVSGLVLEKLARPRLGYAFQRWSTPDPYIYNSPRGKLVAITNENAGSDGDIFSHTFKLMGLGPLIGKRTWGGVIGISPYMPLADGTITTQPEFSFWFKDVGWGVENYGTDPTIDVDYTPQDYARGFDPQLERGIAEALRLIEEYPAATPTPEQHPYRGYPKK
>CP035758.1|QBD75485.1|1195405_1198285_-|tetratricopeptide-repeat-protein
MEMGNRTPDSFGALLKEFRVRRHLTQQQLADVIGVHRNVIGRWEQGNVLPATKSTVLELIKHLQLDGQEARSLLEASLTGLSPYWLVPFHRNLRFTGREEVLKVLHMHLLPERALALTQSCALYGLGGIGKTQIALEYAYRYALEYTAVFWISAETTESIVASFLSIAEVLHLPERRETNQRQIVSAVRRWLTSHGQWLLIWDNMEELELLERFLPPTRHGCVLITARRQAFGTLAHALELSALEQEEGVLFLLRRTNLLGSCATNEDVCQLAQRLPAEYAAARELVQLMAGLPLALDQAGAYVDESGCSIASYLLQYRCQYHQLLARRGTLTTNHPHSVATTLLLSCQQVEQHNPGALELLRHCAFLFPDTIPEELFVVGAPYLSQEIGSVASDSYRFDQALAALRLFSLIRRHPETQTLSIHRLIQVILLAEMSKQERAEYQRRVISMLYELFPEVEYGSFLWGACERLLPHVLAAVSIAPDDAGRQKVAGILRKAASYLRECARYEQAESLFKRAIGIYEQVAGPEHPELAAAFNGLAHLYYDRAHYRQAESLFRRAIGIYERVSGPEHLDLASPLRGMALLFYRQGKYKHAEELYQRALRIQIAALGPEHQQTAYLLDNMAILYVELGKYEKAEPLLQRALQIWEQALGPEHSQISRPLNNLADLYLEQGRYEKAEPLLQQSLRILELTLGSQHPRIAYAVHNLADIYLEQGRYEKAELFYKRALRLWERAFGDEHPNRAYSLHGLARMHRAKGEYGQAERLYKQAIGLRARHRGLKHYETAKSMYGLAELHVEKGEYMRAERLYIQAVKIFEHSLGLTHPQVVKLRTAYSCLLEKRKRGTNERNLLVRLFYARNRSDGAIRTLTREKPATQILESEALTAFLVACCDLHPQAWARSADLWRTYQQWVQEHQERFPLSRQAFTSYLKAHGCQAARTNSARIWRGIGIIDRRRDMA
>CP035758.1|QBD75486.1|1198488_1199028_+|hypothetical-protein
MLVSYIFAFCRVAIGLLFLASFIGKLRAGTQFRQTINDFRLISPRLSQGAATLFLCCELAIVVCMIFGNFLLLPGFLLATLLLCVFSGAIALGLLRKRQVPCNCFGASSQVISPVDLYRNAGLLLCAAGGCGIQSLLKQALQALNWVEWLPVALGAAIFVLLWTQLGELIQLFRPARNI
>CP035758.1|QBD75487.1|1199079_1199661_+|TlpA-family-protein-disulfide-reductase
MEGFLLASTILLWVVVLVNLLLTLALIRRVNTAEPVRRSVDMQTGPAVGSQAPDFSANTLDGQQMSLDSYAGHPTALVFVGPGCQPCHELIPSLKLLAAQAKEAGAELVLVSNGPRDETEKMARDLAIELPILIAPKTENSFLTLYNISMTPSYCSLDEHGVVLGAGHPDPHDAHWQELTSGWSRQESLVERR
>CP035758.1|QBD75488.1|1199757_1200015_-|hypothetical-protein
MDMPTTLRSLAVAAVIFSYGDVCARVKDSYLAKHCVSAIDLSAIIVVLKAAVGLSPGLWRNALSERVQQMVKRAEFAKQGISMIE
>CP035758.1|QBD75489.1|1200152_1200383_+|hypothetical-protein
MQHLLTSADALLSKLGPFNHLLDSLAQHIAPQASAQASTCPQCECYDYCTEIRCSHGYARLERCYQGPDRRIGCDC
>CP035758.1|QBD75490.1|1200708_1200954_+|hypothetical-protein
MQTLLNNTDALISKFAPLSHLLDSLAQRVAPQGKARAGALACVHCYYYCTEARCSHHQARRLHCYDQCDGSVSDVAAGCVC
>CP035758.1|QBD75491.1|1201099_1201339_+|hypothetical-protein
MQTLLNNTDALISKFAPLSHLLDSLAQRIAPQARAKADTCEWCYYYCSKVRCGHGQALRLRCYDECQGTMSDSYAGRCC
>CP035758.1|QBD75492.1|1201526_1202576_+|signal-peptidase-I
MTGVRGNSPSHTSLSSLTQEYIMLQITFLLLLVIVFIAGFIFLLFRTIFLVITVEGASMLPLLQHGDRLLVLRHFGIRQLRKGEVVIIKPPAEIQKGFASGEPAQVYYVKRLVALAGETVTDTLPVSLQAKMPVTREAEGQVEPRLKSWQVPAKHIFVCGDNRQNSLDSRTWGPLPQRSIVGIMLRKLAPSRNATYAKVSTRLEAVPSANFLPPGTPAPAFSAATVNGEICELATYAGKPLVLFFIASERLSRLFIPNYATLARQIAGQSNPAILFACGVELAQAQALVEEFQIEVPVLVTPRATHSLFHDYKIIGTPCYCLIDAQGRLKRDGFLSSGSPQPNRRLSPI
>CP035758.1|QBD75493.1|1202725_1204603_+|ABC-transporter-ATP-binding-protein
MLKNLHNQWKRLIHGFALLWEMLKLAWRAQPLCLLILLLLQVFEGLIPVASGYISKGLFDELSQVFRGIPFTQLLQGLIFLLLAQAAISVVGQLTSPLQDYLQAELNRQLTLSIRQALYKKMNSLSGLAHFEDPHFHNTLQVVASHVQFAPAQTLQTFARLLQGLITLISFFAVLFLLSPLLALGLGLAVIPHLIVQLKLNRQQFSLYMENSPQERRAAYYSQVLSWIPFAKEVRLFLLGDHFLQRFTQTTEHIYEAQRKFQLRELRWQGLLSMLTSCVSTGAFIIVVLQAFSGRISLGDMALYIQAVDNTQKTLMSMAFALSRLGENLLFFKQYQEVQALPDRISHTAHPRPVPQLTQGITFRNVSFRYSENHPWIVRHLNLSLPAGRCLALVGLNGAGKTTLVKLLTRLYDPSEGEILWDGIDIREFEPTEYRRHLGTIFQDFVRYELSAQENIGLGATELLEDLPSIEDAARKAGVHERLSALPHGYQSMLSRWMAEETDGEEDEGTDLSGGEWQKLALARMFLRNAEAIILDEPTASLDAQTEYELFQQFRKLMQNHTCLLITHRFSTVRMADFIAVLEQGSVSEYGSHEELVEHAGTYARLYNMQVESYIGKVPVQEQIG
>CP035758.1|QBD75494.1|1204614_1207335_-|hypothetical-protein
MLEKKPLLTPKFFMPVLPEQALPRSHVLKLLAPSLHRKLTLISAPAGFGKTTLLTLWLHSLTQAGQGAPHVVWISLDQSDDNAYRFWEYILTALVPLTGRAALQALLTLPPPPLEEVLTILINTLAELPEPIVLALDDYHMVSDSAIHAHLIFFLEHLPPCMHLVLATRYDPPLALARWRGKGQLVEIHAEQLRCSREEMATFLAQIMGHALSEEAIALIAERTEGWLVGLQLLALMLQHQPDATQVLQELSGSQRPLLQYLTEEVLDEQPAELRTFLLRTAILERLSAPLCAAVMQNSVAACQDMLEQLERRHLFIVALDTQGRWYRYHHLFAEALRHLLARDMEEAKLWQLYQQVSDCYEQQGMLAEAIEAAFAAQDFARAARLLVKCCQTAPFRSHYLTLRRWLERLPRPWLETSAELCQSYVLVQVLTGQQGNEKLLQLAERHWKSLNQPQRLGQVQVIRALLALKQGGDISSCVALAQQALDYLPREDVYWRSHCVQYISEHLLFNGRGEEVRSMLEEAYALAQQANNLYSMFKIRLHQGSLLQVQGKLHQAASYFHELDTTKELAEFPYLAYVRLLRLVSLYYEWNELARAEFYLARAESLLPHLEKVLLLPQCALYRALIAFARGDYALAEDYCFQAERIAQNSGFVLAVEEVLLYQTRLYLARTDLSSALACLSKASLSPELLLNEMPANEHLDWYSCLIRLLLAQGRNDQARSLAERQALLQKENFASYIEFQLLEILALQAQGQQQSALEELRRLLVRCRPEGYIRIFVDEGKDLVPLLQALSSHEREPFMLSYIERLLQAFAPIQPSAEIAGLAANKQPVCASTSLPESDLLSEREREVLHLLARGASNHEIAEALVITYNTTKRHVHNILEKLQASNRTQAVAQARKLGLLSTE

Crispr_ID: CP035758_5

• CRISPR_ID: CP035758_5
• CRISPR_location: 1371918-1372398
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 6 spacers

Consensus repeat of CP035758_5

Consensus_repeat	Method
GTTACAATCCCTGCCGGGTTCCTCTT	CRT
GTTACAATCCCTGCCGGGTTCCTCTTCCTTTTCTGAC	PILER-CR
GTTACAATCCCTGCCGGGCTCCTCTTCCTTTTCTGACT	CRISPRCasFinder

spacers of CP035758_5

>5.1|1371944|48|CP035758|CRT
TCCTTTTCTGACCTTGGCGAGCCTGGAGCGCTATCTTGGCATCCCATG
>5.2|1372018|47|CP035758|CRT
CCTTTTCTGACTCCAGCGCGTTCGCCAGGAAGCTCGGTTGTTAGCCT
>5.3|1372091|46|CP035758|CRT
CCTTTTCTGACTTTGTCGTATTGTAACTATCCGAGATGGTCTTGTT
>5.4|1372163|49|CP035758|CRT
CCTTTTCTGACTGGATACCTTTTACCGTGTATAAAGACGGTAGCATAAG
>5.5|1372238|51|CP035758|CRT
TCCTTTTCTGACCAGACTACAAAAGCTTATGCGACACTCCCATATTTCCAC
>5.6|1372315|46|CP035758|CRT
CCCTTTCTGACTTTTGCAAAGAAGCTGACAAAATTATTCGTTTTCG
>5.7|1372030|36|CP035758|PILER-CR
TCCAGCGCGTTCGCCAGGAAGCTCGGTTGTTAGCCT
>5.8|1372104|35|CP035758|PILER-CR
TTTGTCGTATTGTAACTATCCGAGATGGTCTTGTT
>5.9|1372177|38|CP035758|PILER-CR
TGGATACCTTTTACCGTGTATAAAGACGGTAGCATAAG
>5.10|1372253|39|CP035758|PILER-CR
CAGACTACAAAAGCTTATGCGACACTCCCATATTTCCAC
>5.11|1372330|35|CP035758|PILER-CR
TTTTGCAAAGAAGCTGACAAAATTATTCGTTTTCG
>5.12|1372030|35|CP035758|CRISPRCasFinder
CCAGCGCGTTCGCCAGGAAGCTCGGTTGTTAGCCT
>5.13|1372103|34|CP035758|CRISPRCasFinder
TTGTCGTATTGTAACTATCCGAGATGGTCTTGTT
>5.14|1372175|37|CP035758|CRISPRCasFinder
GGATACCTTTTACCGTGTATAAAGACGGTAGCATAAG
>5.15|1372250|39|CP035758|CRISPRCasFinder
CAGACTACAAAAGCTTATGCGACACTCCCATATTTCCAC
>5.16|1372327|34|CP035758|CRISPRCasFinder
TTTGCAAAGAAGCTGACAAAATTATTCGTTTTCG

CRISPR arrays and Neighbor proteins around CP035758_5

CRISPR arrays

The CRISPR arrays of CP035758_5

>merge|CP035758|5|1371918-1372398|CRT,PILER-CR,CRISPRCasFinder
TCCTCAATCCCTGCCGGGTTCCTCTTTCCTTTTCTGACCTTGGCGAGCCTGGAGCGCTATCTTGGCATCCCATGGTTACAATCCCTGCCGGGCTCCTCTTCCTTTTCTGACTCCAGCGCGTTCGCCAGGAAGCTCGGTTGTTAGCCTGTTACAATCCCTGCCGGGTTCCTCTTCCTTTTCTGACTTTGTCGTATTGTAACTATCCGAGATGGTCTTGTTGTTACAATCCCTGCCGGGTTCCTCTTCCTTTTCTGACTGGATACCTTTTACCGTGTATAAAGACGGTAGCATAAGGTTACAATCCCTGCCGGGTTCCTCTTTCCTTTTCTGACCAGACTACAAAAGCTTATGCGACACTCCCATATTTCCACGTTCCAATCCCTGCTGGGTTCCTCTTCCCTTTCTGACTTTTGCAAAGAAGCTGACAAAATTATTCGTTTTCGGTTACAATCCCTGCCGGGTTCCTCTTCCCTTTCTGACT

>CP035758|5|1|1371918-1372386|CRT
TCCTCAATCCCTGCCGGGTTCCTCTT	TCCTTTTCTGACCTTGGCGAGCCTGGAGCGCTATCTTGGCATCCCATG
GTTACAATCCCTGCCGGGCTCCTCTT	CCTTTTCTGACTCCAGCGCGTTCGCCAGGAAGCTCGGTTGTTAGCCT
GTTACAATCCCTGCCGGGTTCCTCTT	CCTTTTCTGACTTTGTCGTATTGTAACTATCCGAGATGGTCTTGTT
GTTACAATCCCTGCCGGGTTCCTCTT	CCTTTTCTGACTGGATACCTTTTACCGTGTATAAAGACGGTAGCATAAG
GTTACAATCCCTGCCGGGTTCCTCTT	TCCTTTTCTGACCAGACTACAAAAGCTTATGCGACACTCCCATATTTCCAC
GTTCCAATCCCTGCTGGGTTCCTCTT	CCCTTTCTGACTTTTGCAAAGAAGCTGACAAAATTATTCGTTTTCG
GTTACAATCCCTGCCGGGTTCCTCTT

>CP035758|5|2|1371992-1372397|PILER-CR
GTTACAATCCCTGCCGGGCTCCTCTTCCTTTTCTGACT	CCAGCGCGTTCGCCAGGAAGCTCGGTTGTTAGCCTG
TTACAATCCCTGCCGGGTTCCTCTTCCTTTTCTGACTT	TGTCGTATTGTAACTATCCGAGATGGTCTTGTTGT
TACAATCCCTGCCGGGTTCCTCTTCCTTTTCTGACTGG	ATACCTTTTACCGTGTATAAAGACGGTAGCATAAGGTT
ACAATCCCTGCCGGGTTCCTCTTTCCTTTTCTGACCAG	ACTACAAAAGCTTATGCGACACTCCCATATTTCCACGTT
CCAATCCCTGCTGGGTTCCTCTTCCCTTTCTGACTTTT	GCAAAGAAGCTGACAAAATTATTCGTTTTCGGTTA
CAATCCCTGCCGGGTTCCTCTTCCCTTTCTGAC

>CP035758|5|4|1371992-1372398|CRISPRCasFinder
GTTACAATCCCTGCCGGGCTCCTCTTCCTTTTCTGACT	CCAGCGCGTTCGCCAGGAAGCTCGGTTGTTAGCCT
GTTACAATCCCTGCCGGGTTCCTCTTCCTTTTCTGACT	TTGTCGTATTGTAACTATCCGAGATGGTCTTGTT
GTTACAATCCCTGCCGGGTTCCTCTTCCTTTTCTGACT	GGATACCTTTTACCGTGTATAAAGACGGTAGCATAAG
GTTACAATCCCTGCCGGGTTCCTCTTTCCTTTTCTGAC	CAGACTACAAAAGCTTATGCGACACTCCCATATTTCCAC
GTTCCAATCCCTGCTGGGTTCCTCTTCCCTTTCTGACT	TTTGCAAAGAAGCTGACAAAATTATTCGTTTTCG
GTTACAATCCCTGCCGGGTTCCTCTTCCCTTTCTGACT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD75640.1|1372695_1374003_-|Y-family-DNA-polymerase	unknown	unknown	gnl|CDD|176454
CP035758.1|QBD75644.1|1376863_1380061_+|hypothetical-protein	unknown	unknown	gnl|CDD|225461
CP035758.1|QBD75645.1|1382291_1382936_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379883
CP035758.1|QBD75637.1|1366011_1366686_+|hypothetical-protein	unknown	unknown	gnl|CDD|340863
CP035758.1|QBD75646.1|1383028_1384003_-|SDR-family-NAD(P)-dependent-oxidoreductase	unknown	unknown	gnl|CDD|236099
CP035758.1|QBD75632.1|1358294_1359293_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75643.1|1375313_1376717_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75636.1|1365402_1365951_+|MFS-transporter	unknown	unknown	gnl|CDD|340863
CP035758.1|QBD75647.1|1384252_1384657_+|ATPase	unknown	unknown	gnl|CDD|176907
CP035758.1|QBD75635.1|1361962_1365073_+|hypothetical-protein	unknown	unknown	gnl|CDD|225461
CP035758.1|QBD83386.1|1380412_1381297_+|NmrA-family-transcriptional-regulator	unknown	unknown	gnl|CDD|187542
CP035758.1|QBD75634.1|1360964_1361681_+|ClbS/DfsB-family-four-helix-bundle-protein	unknown	unknown	unknown
CP035758.1|QBD75639.1|1369021_1371787_-|hypothetical-protein	unknown	unknown	gnl|CDD|225461
CP035758.1|QBD83387.1|1381385_1382285_+|alpha/beta-hydrolase	unknown	unknown	unknown
CP035758.1|QBD75642.1|1374684_1374936_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75631.1|1357109_1358093_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224054
CP035758.1|QBD75641.1|1374014_1374449_-|translesion-error-prone-DNA-polymerase-V-autoproteolytic-subunit	unknown	unknown	gnl|CDD|224885
CP035758.1|QBD75633.1|1359440_1360820_+|hypothetical-protein	unknown	unknown	gnl|CDD|284250
CP035758.1|QBD75638.1|1367967_1368882_+|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|375319
CP035758.1|QBD83385.1|1366933_1367812_-|oxidoreductase	unknown	unknown	gnl|CDD|381314

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD75640.1|1372695_1374003_-|Y-family-DNA-polymerase	gnl|CDD|176454	cd01700, PolY_Pol_V_umuC, umuC subunit of DNA Polymerase V. umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.	4.12729e-140
CP035758.1|QBD83386.1|1380412_1381297_+|NmrA-family-transcriptional-regulator	gnl|CDD|187542	cd05231, NmrA_TMR_like_1_SDR_a, NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs. Atypical SDRs related to NMRa, TMR, and HSCARG (an NADPH sensor). This subgroup resembles the SDRs and has a partially conserved characteristic [ST]GXXGXXG NAD-binding motif, but lacks the conserved active site residues. NmrA is a negative transcriptional regulator of various fungi, involved in the post-translational modulation of the GATA-type transcription factor AreA. NmrA lacks the canonical GXXGXXG NAD-binding motif and has altered residues at the catalytic triad, including a Met instead of the critical Tyr residue. NmrA may bind nucleotides but appears to lack any dehydrogenase activity. HSCARG has been identified as a putative NADP-sensing molecule, and redistributes and restructures in response to NADPH/NADP ratios. Like NmrA, it lacks most of the active site residues of the SDR family, but has an NAD(P)-binding motif similar to the extended SDR family, GXXGXXG. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Atypical SDRs are distinct from classical SDRs. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.60241e-65
CP035758.1|QBD75645.1|1382291_1382936_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|379883	pfam16859, TetR_C_11, Bacterial transcriptional repressor C-terminal. This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli.	5.07276e-19
CP035758.1|QBD75637.1|1366011_1366686_+|hypothetical-protein	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.5938e-15
CP035758.1|QBD75646.1|1383028_1384003_-|SDR-family-NAD(P)-dependent-oxidoreductase	gnl|CDD|236099	PRK07791, PRK07791, short chain dehydrogenase; Provisional.	4.08107e-117
CP035758.1|QBD75644.1|1376863_1380061_+|hypothetical-protein	gnl|CDD|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	7.74994e-106
CP035758.1|QBD75636.1|1365402_1365951_+|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.59546e-26
CP035758.1|QBD75635.1|1361962_1365073_+|hypothetical-protein	gnl|CDD|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	1.69366e-116
CP035758.1|QBD75647.1|1384252_1384657_+|ATPase	gnl|CDD|176907	cd08898, SRPBCC_CalC_Aha1-like_5, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	3.45353e-26
CP035758.1|QBD75631.1|1357109_1358093_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	4.92291e-92
CP035758.1|QBD75639.1|1369021_1371787_-|hypothetical-protein	gnl|CDD|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	3.6101e-132
CP035758.1|QBD75641.1|1374014_1374449_-|translesion-error-prone-DNA-polymerase-V-autoproteolytic-subunit	gnl|CDD|224885	COG1974, LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms].	7.47168e-31
CP035758.1|QBD75633.1|1359440_1360820_+|hypothetical-protein	gnl|CDD|284250	pfam06782, UPF0236, Uncharacterized protein family (UPF0236).	0.000411939
CP035758.1|QBD75638.1|1367967_1368882_+|XRE-family-transcriptional-regulator	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	4.16083e-48
CP035758.1|QBD83385.1|1366933_1367812_-|oxidoreductase	gnl|CDD|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	1.27688e-120

Protein sequences

>CP035758.1|QBD75639.1|1369021_1371787_-|hypothetical-protein
MGIEPKEKKDPQREANINPILHAKLSIPTARIKLLPRPHLIAQLAQSAHHKLTLLSAPAGSGKTLLLSAWSKQIDAPLAWLTLDESDNDPARFWNYLLTALAKLYPEPHISLSNSSYAPLAQTIPSILTLLINALAELQHDRFLILDDYHLVQDQTIHASLAFLLEHLPVHIHLVLASRSDPPLPLSRLRVSGELLELRSADLRCSPSEVASFLRDCAELHLSPNASELLARRTEGWWAGLQLAALSLQKMADDNQREQFVRTFSGQDRYILDYLLEEVLQHQPPSVQRFLLETSILTDLNGSLCSALCPWGNTQEILENVVRANLFLVPLDHERHWYRYHQLFAAALRHRLHLAQPEHVPQLHQRAANWLASHAMLVPAIEHALAAGNVAQASQLIIQVAETLLMRGEVSRMQQWLDGLPTSLVRAHPFLSVAYAFLLLMRTQLEDIEERLQDAERALAHEQSALALVESEALTPARLRGMIATVRSTVSVNLGDTEQAVNAAQYALEYLSPQDHALRGLILHNLGDTYKMRGETATAMQMLQKAVALNQDSGNLFVALTALCDVGKLQAIQGQLRQAADTYYRALELGALPAQQGGSSLLSAGKAQVYLSELLYEWNELDNALYYAQESVQRCKEWSHIRHLLEGYIVLAQVHYARTNIQAAHDTLNIALGLTDEIKAASQHLVTNRQDMRLLELIERVETLQAHFWLVEGEIERAELWLRERGFNLEIHPCLHPYAALALSRLLLLQKRPELAQRLLEPLIQETEAKGEILQLIDLLAWQALTLQQQGQLERALSAIARALALAEAEELVRTFVDKGHAMFVLLQRAAHQGIAPRYCQRLLLAFSLPGVQGETLVELSKRELEILQLLASGKTNREIGALLTLTTGTVKWYVHEIYNKLGVGNRTRAIAEARRLHILT
>CP035758.1|QBD75638.1|1367967_1368882_+|XRE-family-transcriptional-regulator
MENVQRREMLAQFLRTRRARLSPADVNLPVGQHRRTPGLRREEVAHLANIGVSWYTSLEQGRDISPSPEVLHSLAIALRLTAVERQHLFLLAGQPSAFSAAKIVEEEDISPTVLRLLEDLNPSPAYIMDWRWNYICWNTAASALGVTRTSPPYASNIVWRTFTSRPEPAEYADWVAIAQKILAEFRAESMQYADDEWLQQLIADLHRVSPEFREWWSLQDVRERSDGKKAFDHPLVGRLHFEHTTLQVAAHPGLKIMIYRPLPGTDTASKLHRLFEINMSTESAVNWVKSARLLRESDKTSMKS
>CP035758.1|QBD83385.1|1366933_1367812_-|oxidoreductase
MEEQHTISAWAAGTLTLGKDLVVNRLGFGAMQLPGPGVWGEPASPEEAKAVLHRAVELGVNFIDTAAFYGPEVANRFIQEALYPYPEGLVIATKVGAKRGKDQSWSADMRPERLRAACEENIRQLRLDPLPLVHCRYMEDADVPFGEAVGTLAELQRKGMIRHIGVSNVSLQQLREAQAVTSIVSVQNFYNFAYRQGEDLFEVCRREQIAFIPAFPLAMGQFEHFGSRLDALAQRYHATTAQTALAWLLTCSPIMLPIPGTSSRVHLEENIAAAGIRFTEEEMMLLEDHGSH
>CP035758.1|QBD75637.1|1366011_1366686_+|hypothetical-protein
MFFIRGVHPAKAVNATTSGIVAQPLTFWHLLSHSFVLQLLLLLIVSVSIGTGAMFEVALPALLHNQLHTSASGYGVIMAAFSIGTVAGSLAAGGLGKVPYRLALSLVCFLIEAALVILLPFMGSVSIGVVIMLGMGLLNGLVVVTVMSVIQGQLPMHLIGRVMSLISFAIYGPYPISVALAGVIVPRYGSTPVFLAVGLLIGVPALVGCLQRSFWQRGGVKLIR
>CP035758.1|QBD75636.1|1365402_1365951_+|MFS-transporter
MMPGPLSNKHQAPKLFSIRSMFVPLHNRNFSLLFGGQLISNIGDALYYVALPWFMLSNGGGAQALGIVLGVFGVARIGGTLLGGALSDKLQPRRVMFVTDIMRMVLMAFLSFLMFQRHPMLWSLCLVSALLGFFGGLFLPASMSMVPSLLDGDELQAGNSLMNSATQLASAAGLGMAGIVVA
>CP035758.1|QBD75635.1|1361962_1365073_+|hypothetical-protein
MAAAYTLIWLPEQQAYALSLRGQTSMQLFSGEDERWFAWLATCSSFAFQGQSGHLTLRKETRKRGKGYWYAYRTRRQRTRKRYAGRSDDLTPARLEACAASFTDTEHASTSLPIPVPLPNLSPVLEPKLHLPHLQDPLVTRSRLLTRLNAALQHKMILISAPAGFGKTILVRQWIETQSQDTQTAWLSLDPEDDDPIRFWHYVLTACLAFSGQPSQHALRHLSTDGPFFPLSLLKKILTAFLNDLIKLPSPCLLVLEDYHVITSSQIHESLAFVIDHLPPTLHLVLTTRAEPPLPLASWRAHRELVELRANELRFSHDEITTFLHQALPFALPTELLQPLEAHMEGWPTGYLLLSLALQGKSERKDIEQVLANFSGSHRYVLDYFALDVLSAQPKAFQRFLLQTSLLGRMTSSLCAAVTGYQNSQQLLSEAERAGLFLQALGGEPAWYRYHALFAEALQEEARHRLEKEEWQGCLSRASTWYEQHGMFAEGIEAALEAEAWTRAATMMERFLNMQNRSIMYEHATVLRWLERLPDQTLETHPGLCINYAAALLFTLDRYSPATMALIEELLSRAERLHEREEAWDKLSEALSCHAEVARWQGNVPQAIRLARQALHLPADSQAPWQGTSIVALATGELCAGRPQEARRLMLEGMARFETPLPWYDTRGVAFTLADISLRQGELRQAEQSYRHLLATANDNPVERVQAHLGLAQLAYEWNDLIVAGEHVAQALELGRTHLEELGPYYVETGIRFPCELLQARLQQARGNYAQALQTLQALVSHAQEQLWNYRYYVQLWSYLYRVALAQQAELSLACGELTAVERWQETCRQLGEHFHVFQQEQEALLCAHFLILRGEIPQALHLLKRWQDDARANRRLRSELEISLLMALAYAASSQPSQAEQALTEALRLGQAQSFQRLFLEKGETLATLLRAYLLDAREESLICYGRDVLRAFAGSGTKSYPASQATSIGLWESLTEAEQRVLGLLVAGRSNPQIAEALVVSINTIKTHVQSIYRKLGVKSRWEACEAARRLDIF
>CP035758.1|QBD75634.1|1360964_1361681_+|ClbS/DfsB-family-four-helix-bundle-protein
MTVQPFKSLILELLQQGHHDEEAFLQELSEAELNANGTWKLWSVKDHMAHKTFWHQHLIEKLTAILQHQALPPGEEDEEQLNSITFEKHKLQPFSALHAESERVYVQLIKIVEQLSEEELTTSRRFSAISDDYPLYTVFLGSCYEHDEEHLAYYYKDRHDLLRAIQIRERCASRIMQAEIVPDWVKGSFLYNLACFYTEQKQWENAAARLQEAVARNPDLKERAKSDPELAALHNQSA
>CP035758.1|QBD75633.1|1359440_1360820_+|hypothetical-protein
MRIQVSLTLELNASADLSQMEAQIQEAGQSCMRQALKKAVGAWEQAHRSCPRCGSQLVRTEGTIPRSILTLFGPVDLTRRRFRCQRCQRRFTPSGILLAGLQLRRVRAPLKEAAVLAGASWPYRHAAAWLARLRGAHISAEEIRLLTNQAGASCAQRHLSQASQQLTSPPAPAQAATANRSSSPQELAVIGLDGGWVCSREQRGGMEGKVGVIASGYEGGKEPEEPNGNMTWFHLARYVQSHRHPPRVRSRWNTRRYVATFASSRILGTLAAQALQELGLASQPQVVVADGAGWIKKETDTHFPEAQRILDWPHLWRTMRKAANAVRLLRACSAKAHAQQVEHLGTWLWNGQVERAQALLETWRQELAARQGPAGPALRQAITSLQQQRDWIGSYQRWKEQGFPVGSGIIERAVALVINRRMKRRGMRWLRTNASAVVALRVDLLNADWQRPRSSRCFP
>CP035758.1|QBD75632.1|1358294_1359293_+|hypothetical-protein
MKKQTKQQAILHQLRSLADQPREQAHYALEVLERERGQQVASAALAVLTDIPLPAGRPLLRQLYEHYAEAGVKRDAGGALRIALIGALLPIVEPQDQALAERAISTYEFMPPNREECTSGLRTAGLVLLSNLNHVLASFHCTRLLFDEYTSCMSGEPAVSAVRLLASLESNLLYQGHLLPLYSYLFQRKCHPEVEGECLRQLAKAPEEIVENILSHYTTRISVGTGALVPRHVGKDDVVLLGLFDLLLAHSKGSSLSFIEEFLHETRRYNIYHYVLTMIIANHSSQAWELLLKVAQDEQEPEKIQLLLAALTLVQHDPAIEKLMHQLRQKAV
>CP035758.1|QBD75631.1|1357109_1358093_-|ABC-transporter-ATP-binding-protein
MDTSAKSLPAISITALSKHYRLAGKSVRKAVDQLDLSIAQGQIYGLLGANGAGKTTIIKMLCGLIIPTSGHIVINGYDLARERYRAVQQIGAVLEGTRNVYWRLSAWENLLYFGRLKGCRERELRIRARQLLEELELWERRNSAVRTFSRGMQQKVAIACAVIADPSIVLLDEPTLGLDIQAARTVKDWVAKLAREQGKTVILTTHQLDIAQQLCERVAIMRHGQLLADQPLTHLLKYFREEHYQIRLRGQLSSEQAALFAPLNMSYADGESCLTGLIGNQAQLYRYLADIERLQLPLLAVQLLEPSLEEVFMRLLSAGKEVKDHVA
>CP035758.1|QBD75640.1|1372695_1374003_-|Y-family-DNA-polymerase
MQRTFALVDCNNFYVSCELVFRQAHSYQPVVVLGNNDGCVVARNQAAKALGIAMGTPYFRCRCLLEQHDGLVFSSNYALYQDFSDRVMQVLASFCQRMEVYSIDEAWLDLSFLPPEKVTRYGQQIRAQVLQRTGIAVSIGLASTKTLSKIACYLVKHAPGYRGVLNLADLSEEELDGHLGLIDAQEVWGIGRQTAQALQRRSILTARGLKYADHRWLRHLLNVTVQRAALELRGICCSPVTSKAKRCQDLLTSLSFGRPIERLEELEEAVAFYAARAGEKLRKQRLQASRIGIFIHTNPFERGSAQYAGSAELTLPFPSAFTPELITATKRLLRQIYRPGYRYKKAGVYLSELRPSYVLQPDLFGAFSWEEEARKARLMAVVDLVNEYVGRGALFWGAQGLQRSWEMKRQRLSPRYTTRWPEILRVPTASEYHGP
>CP035758.1|QBD75641.1|1374014_1374449_-|translesion-error-prone-DNA-polymerase-V-autoproteolytic-subunit
MSNVSVFFPAAAGFPSPASGWEERRLDLGDLLVSDPEATFFVRVQGHSMQEAGIHDGDLLVVNRALEPVHRSIIVAVLHGTLMVKRLLIEGERRLLKAEHPRYPPFVLKENTDFAIWGVVTAIIHPLVPSPLVQTLRRSSFHRP
>CP035758.1|QBD75642.1|1374684_1374936_-|hypothetical-protein
MTNERTAQSSPAQQDVLNVLEQLNRAHRAYDVALPSEKRLQIATTFHHLYMWLLQRHIPFRYDPSRHCYFLTESYVRQEVKSL
>CP035758.1|QBD75643.1|1375313_1376717_+|hypothetical-protein
MDALFYWGEGGQYGPYHAQRDGWPNAGEVQRDYREKRRLSATEFAECYSEALQKLGKQNKKGKAGAQGKISGTWILNMEKQNRVPTDIERRRIIAELLDIPPILLGLATLQDVILQPQKEISMQPAGPHILNKLATDLTKYEKNVRVALHIHRTSSAQGLLHDINTELQDLKKLASQAKGNFLSQVRELLLSNNLLATRIMKDAREYALAYMYANDAVQVARSMDDADLIATAYYMRGCAKAEWGRRGTVKQGIFQLEPAKIQEAILDFQKVLALAHKKRGRIHPQLEGFTKLQLSRASGMLKEGERDSRIAQALTMSEEVADVVGADPIDDFYTRALITGTLSGLHMGGYHLGRAETFNAVGLHGKALNELNHVKKLTEGTYGGDETRYQAWFDVLMAESLVGLKDYSEATERARSALLIFHNIHSLRNIASIKDIYSRIAASSYGPSADVKELGAMLKEWYKDEG
>CP035758.1|QBD75644.1|1376863_1380061_+|hypothetical-protein
MAKTRQAALIWSQEDQQYLWCDEHATDAIDVRERPEAWLTRLATSTSFSFQGREGHLTLLKEARPRGGDGYWYAYRRQGKRTAKKYVGRTTNLSATRLEQMARALWYPAEQRNRDHSNEVGGGAANGREWRTSNMVEQQQTNVSPIPQLPLLVPKFHLPPLHPGLVPRERLLTQLDRALEHKFTLVSAPAGFGKTTLVRQWVAQRSTQPHVPPMAWVTLDGGDNDPVRFWRYLMTACQAFGDNIAQEALMLLLSTPQPPFEASLTEAALTIFLNALAQREQGGILLLDDYQAITSQRIQQTMTFFLAYLPANIHVVMMTRSDPPFPLAQLRARNELCDVRSSDLRFTQAEISAFLQLELSVPLAPEVAQCANAYLEGWAAGLRLLLIALREPAAPREIEPLLKVLAGGKPALQDYFITEVFNTQPEPVQRFLLQTSVLTLLTGSLCEALTGARESEQILETAARANLFLEPLGSPTRHPSPAQQWYRYHGLFAETMRAEARRRLGEEKIRELSAQASLWYEAHHLLTEAVESALYAQDYLRAAALIELILREPPTAYQANEYHTLSTWLQQLPEALLAGSPALCLGYARALLYRAEAWRLSPATQALLEKLFKMAEERYQAEHDLPRLGEVFAFRSLAAWRREDAIEAANYARQALAWLPEEQQVWRALSLGVVGKVELLYKGRVEEAQEMLEEACAWCEETDQRHARLTRATINILAHALFEQGKLHRSYEYYQKALHKAKEEYVHRDIMAHTLCGLARISYERNELEQARQQAEELLAIGRDLALEYHEVQASLLLARIQHAQGETTGARQRLDTLLARLPATQLDSAWPLSRELLILQARLALADGDLLAVQRWIASLEQADSTQFPFASEQEMLMLARWHLTLGRKEVALGLLQDLLQEAQKAGRRHSTFEVLALQTQAYAEHEQQAQQILLELLAQTCPEGYLRLFLDEGEAMAALLRSLVLHVREQPVLASLQSIIRAFPGSSSKLASSPATLLAEPLSSQELRVLHLLVPGRSNAEIAGELVVSVNTVRTHIQNIYRKLDAHNRAAAIEVARQLHLIS
>CP035758.1|QBD83386.1|1380412_1381297_+|NmrA-family-transcriptional-regulator
MIVVTAPTGLIGHQVLNNLLASSEPIRVIVRDPSRLPAHIRDRVEVVQGSHSNPDVVTRAFAGADAVFWLVPPDPQAESVHAAYVDFSRPACDAFKSQGVKRVVGVSAFGRGAAVSGNAGYVTASLAMDDLIASTGVGYRALAMPGFMDNLLHQVESIKNQGMFFDIISGDLKQPTCATRDIATVATSLLLDHTWSGVASCPVLGPEDLSYNDMAQIMSEVLDKPVRYQQIAGSALKAMLTGSGMSNAMAQGMLDMMMAYDQGLATAEPRTPESTTPTSFRQWCTEVLKPAVLA
>CP035758.1|QBD83387.1|1381385_1382285_+|alpha/beta-hydrolase
MLQQIADGYGQQRRSPVMHTPAELGLDYENVTFPSRDGVPLEGWFIPAAGSNRLIIANHPLGFSRSGLPTQFEPWHSQWAPSGNGFEINFIPDYKILHDAGYNVLAYDLRNHGFSGAANGGIASGGIFEARDVVGSLQYARSRAETRDMAIGLFSRCLGCSSTFSAMAQFPEAFNDVRCLVAPQPVSTQIIMQRRLALAGVAAERIKDLEQRIILRTGLGFAARNPREWAKHVCIPTFLYQVHDDILTQPSDVQTMFDNIPIAEKQLLWIYGTTARWDGYVEFQRRPQPMLEWFAQYMS
>CP035758.1|QBD75645.1|1382291_1382936_-|TetR/AcrR-family-transcriptional-regulator
MRSIPESSEDEPRRKPGRPRSKEAHQAILDATLEILAEVGLQAMSIEQVAARAAVGKKTIYRRWSSKEALVSEAIRNLQADMPVIDTGHLRADLISMYRTAWQSLQNRPLIRPLYLRLLSECEANPAVFQVFVAQLALPRFQQFVQMVEKAQARGEIRQDLDLQLVTDLLIGPILFRWLATSTLLPAATQADLASFSEQMTDLILHCLAGQAAR
>CP035758.1|QBD75646.1|1383028_1384003_-|SDR-family-NAD(P)-dependent-oxidoreductase
MGSLAGRVAIITGAGQGIGREHALFFASEGAKVVVNDPGVAVDGSGGDSSLAQRVVDEIRAAGGEAVANTDSVADWQGAQRLIRSAVEAFGDLHVVVNNAGILRNELLLNMSEQEFDTVIAVHLKGTFAVSHWAALYWREQSRAHPQVDRAIVNTSSGSGLHNPLPTEVNYAAAKAGVAAMTIVAAIELQPYHVRVNCIAPSRARTRATVDLPGIGGATQDGQFDPFHPGNVSPVVAYLCMADCPFNGQVFSLHGGTVIRYHGWSLGEEIRSDQRWSIYDLTRAMQTLPNPDPLANLLSALGVLGPEAQEQMRHMIEASLTKER
>CP035758.1|QBD75647.1|1384252_1384657_+|ATPase
MEPVVIERSIVVKADRERAWKAITTPELIEKWFEPIYFERLAVGEALTFTWGGKGSIALVEPMERFGFRWQSAKPHPAQTLVIFVLETVSEGTRITVTEQGFEALPEEIRQAHFQQNTQGWEKELGELSAYLQG

Crispr_ID: CP035758_6

• CRISPR_ID: CP035758_6
• CRISPR_location: 1520798-1520909
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of CP035758_6

Consensus_repeat	Method
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	CRISPRCasFinder

spacers of CP035758_6

>6.1|1520835|37|CP035758|CRISPRCasFinder
ATGAGCATCTAGCGCTCACAGCGAGCTTGAAGCACCT

CRISPR arrays and Neighbor proteins around CP035758_6

CRISPR arrays

The CRISPR arrays of CP035758_6

>merge|CP035758|6|1520798-1520909|CRISPRCasFinder
AAAGCTCTACCCTCGAAACGGGCCATGCCTCCTCAACATGAGCATCTAGCGCTCACAGCGAGCTTGAAGCACCTCTTGCAGTGCCCTCGAAACGGGCCATGCCTCCTCAACC

>CP035758|6|5|1520798-1520909|CRISPRCasFinder
AAAGCTCTACCCTCGAAACGGGCCATGCCTCCTCAAC	ATGAGCATCTAGCGCTCACAGCGAGCTTGAAGCACCT
CTTGCAGTGCCCTCGAAACGGGCCATGCCTCCTCAACC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|372595
CP035758.1|QBD75749.1|1507982_1508516_-|HNH-endonuclease	unknown	unknown	gnl|CDD|224321
CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
CP035758.1|QBD75762.1|1529026_1529281_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274680
CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase	unknown	unknown	gnl|CDD|225031
CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187585
CP035758.1|QBD75759.1|1526060_1526387_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224393
CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein	unknown	unknown	gnl|CDD|319914
CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133399
CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein	unknown	unknown	gnl|CDD|235986
CP035758.1|QBD75757.1|1522114_1522402_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75750.1|1508612_1509938_-|MFS-transporter	unknown	unknown	gnl|CDD|340883
CP035758.1|QBD75763.1|1529346_1529598_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75765.1|1530086_1530371_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl|CDD|379079
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator	unknown	unknown	gnl|CDD|333815

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	1.7e-20	68.3	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase	gnl|CDD|372595	pfam13419, HAD_2, Haloacid dehalogenase-like hydrolase.	4.93133e-33
CP035758.1|QBD75749.1|1507982_1508516_-|HNH-endonuclease	gnl|CDD|224321	COG1403, McrA, Restriction endonuclease [Defense mechanisms].	6.8094e-05
CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.19268e-68
CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	5.7507e-41
CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase	gnl|CDD|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	2.53934e-42
CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase	gnl|CDD|187585	cd05324, carb_red_PTCR-like_SDR_c, Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs. PTCR is a classical SDR which catalyzes the NADPH-dependent reduction of ketones on steroids and prostaglandins. Unlike most SDRs, PTCR functions as a monomer. This subgroup also includes human carbonyl reductase 1 (CBR1) and CBR3. CBR1 is an NADPH-dependent SDR with broad substrate specificity and may be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds. In addition it includes poppy NADPH-dependent salutaridine reductase which catalyzes the stereospecific reduction of salutaridine to 7(S)-salutaridinol in the biosynthesis of morphine, and Arabidopsis SDR1,a menthone reductase, which catalyzes the reduction of menthone to neomenthol, a compound with antimicrobial activity; SDR1 can also carry out neomenthol oxidation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.92932e-89
CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator	gnl|CDD|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	0.00377578
CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein	gnl|CDD|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.84308e-35
CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator	gnl|CDD|133399	cd04772, HTH_TioE_rpt1, First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE. Putative helix-turn-helix (HTH) regulatory protein, TioE, and related proteins. TioE is part of the thiocoraline gene cluster, which is involved in the biosynthesis of the antitumor thiocoraline from the marine actinomycete, Micromonospora. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Proteins in this family are unique within the MerR superfamily in that they are composed of just two adjacent MerR-like N-terminal domains; this CD contains the N-terminal or first repeat (rpt1) of these tandem MerR-like domain proteins.	4.54058e-14
CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.48211e-32
CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein	gnl|CDD|235986	PRK07313, PRK07313, phosphopantothenoylcysteine decarboxylase; Validated.	3.01045e-17
CP035758.1|QBD75750.1|1508612_1509938_-|MFS-transporter	gnl|CDD|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.29004e-65
CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator	gnl|CDD|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	4.39206e-22
CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein	gnl|CDD|379079	pfam13229, Beta_helix, Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	3.04827e-15
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	5.7578e-18

Protein sequences

>CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator
MASRPLRTSDIARELGVHVNTIRLYESWGYFSDIPRGTNGYRQFSTLHLEQARLAHLTLSTPYLGDKNLLIDLVKYAAHGDFAQALEQAYRYLAYVRMEITTTEAALEFLERWAVGQIRETTHQKMHIRQAAQYLNVTVDMLRNWERNGLITVPRDSSNGYRLYGPSEFGRIRVIRTLVQSGYSLMAILRMLQQFDAGHTENLHATLEIPREESDVEYIEIIADRWHSTLLELENRAQAIIRQLGSLIEMTHAS
>CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein
MPQHQFYVAPQGKDCWPGTYAQPFATLQQAQQHVRANTANQRSDIIVNLRAGTYFLATPLQFLAASGDSGEHGYDVIYQAYGYGTNKQEHVVLSGGREISGWQPYDEDSAIWQAEVGDLNTRQLFVDGQQAQRASLPSIPTLTRTETGYVVHDTTPQSWRSPADIEFVYQGIYPWSSARCGVASITGDQHSTTITMDQPAFSWANQLYTVEGRDRANWTGLGSPTAIENSVSFLTQPGTFALDRSRPGHHILFYMPRPGEDLARVSVIAPLLETLVSGQGTAEAPLHNLSLRGITFAHATWLQPSKPEGFLHYHGITYYNGGHIETVIYDPETQSSVTVPSDPARMPGNVTFSSATHILIEGCRFSHLGANALEFSKDCQDNLIRGNVIHDVSAAGIVIGTGASSRENRGNRIENNWVHHTGLEYHGSPAIYLAETQDSTIVHNQINDVPHCGIVVYGGSTARNTSVLNNLVFNTMKVLADGGGIYISSNQGASFASGTVVRGNVIHDTITSYNFGLYVDYGASWVTMQANVVYNSDTPTALQVEPPLQHVAFIGNFWDMNPDGYDNPPEYVTVAGNTRLPRDGFEPALLDNPASADIVTNAGLEPSYLHLLQM
>CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator
MESSVLDIPKMTRLLTALGEPARLEIIDQLAKQEQMNVGDLASKFSLSRPTISHHLKILKEAGVVQAEKSGQETYYRVNRDMLILGLQDIADTLKRCWTHTEP
>CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase
MPQPQKIALITGANQGIGLEVARQLGKQNILVLIGSRNWTRGKEAAQQLVAERIEAQAIQLDVTDQQSIEEAARQINDSYGRLDILVNNAAIAPVQDSQPKERPLDKIRAIFETNVFGLFAVTQAMLPLLHRSSAGRIVNVSSGLASLGTLSNAPAAALRPFSWPYPSSKTAVNSITIFLAKQLEQSAIKVNAVDPGRTATAMNPQATRTPAQAAQTIVHYATLASDGPSGGFFGEAGSLPW
>CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450
MVTDTAVPRPRSSLPGPQGLPLLGAKMHLLQLYLHPFVRLRELYTTYGDIVVLTRNNPMLVFAFGPQHNFSLLSNPDLFYASSEKSFEKVPRGTAFTHILRNNLQHLDGEPHQRQRHLMMPAFHERQIVNYHRDIVEQTQSLLDSWGIGRELDLAREMQRLTQNVVDKTLFGLADDEKVARLRAQIHKLTKVMALGAGLPIDFPGLPYRQALQLAQKFATEMRELIEQKRGQAEATDMLTVLSQSHDEVGEKLTDDQVIGQVFAFYTTAYQTIANALTWTNFLLMQHPHILANLLAELDEKLHGAPPTSAQLSQLPLLEGVIKEGLRLFPPAIIGKRIAMSTCELGGYELAAGTTIVYSEFLTHRLPELYTEPNRFRPERWLTLEPSPYEYLPFSAGQHRCIAAPFAMQELKIVLAIMLQRYRLALRPNLKLSVDFTMRAKPGMPVRIFAQDRQFKRTPVRGPILDMLEGI
>CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator
MPEKLPISQEGATKASDNAPPLPKLLASSQELGWEGIAVQAYHEPAELEWSGPGSPDSSLILVARGSLHMEHRPVNGSWSGKSFYQGDLLLQPGVTTASELHWKGLSSEPLHLLYIHLSQELLSRTAQELTKHDPARLDLIGHAGFHDPLLSQLALALWRELEQSAPAGKLYGQAAAQMLAVHLLRHYTAFSIDIQERSQGFTPRQMNHLVDFILAHLSENLSLETLAQQVGFSPYHFARLFQETTGKSPHQFVKQQRIERAKKLLRETDVPLAQVALESGFSNQSHLTRVFKHHLNLTPRVYRHDRSISAPF
>CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein
MKPRVTVITLGVNDLEKSLQFYRDGLGLPTQGIIGREFEHGALALFDLQHGLKLAIYPRNDLAFDAKVPLSVPNATECTVGHYLKNKAEVDAVMEQARQAGALITDQAHDRPWGIYSGYFQDPDGHLWEVVWDPRFETEIIE
>CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase
MQYGIHVPIFGPYGEVRVLADLAHEAEEAGWDGIFLWDQVSRTTLSPTLDPMIDPWIALTAIALRTHTIRLGPLVALLPRRRPWIIARQTLSLDHLSSGRLILGVGSGGSYFDFEALGEATDPKTLAGMLDESLEVLTGLWRGEPYRFEGKYYHIKEAQFLPRPVQSPRIPIWVAGEWPAKAPMRRAARWDGVAPLGRNISLTAMLTPEQMEEMVNYVRSQPGYSAPFEVVHSGFTSGTNRAKDRDIVAAYQQVGVTWWIEKILPERWGSWTDWPLEAMRQRIRSGPPR
>CP035758.1|QBD75750.1|1508612_1509938_-|MFS-transporter
MHTMSSEHEKTNTADLGRADVTSTGQHVDRKKRINKSLFILPASLALIMTGFGIIIPVYPQRLEALGLGAETLALMEGGFGLGMFLFSTPMGVWANRFGRKPLVLLALLGFVATNLLLAFVNIPAFFIAIRFLEGILVAGFMPAAMAMIGDAIPPEKQGRWMGVMTTAQAGGVALGPAIGGVLYQSWGFTSPFLLSAAFALASALLAIFMLPETLPEQVRAEALANRDRKKRGEKELDVNRVSLIHLAWAFAALLFIDFGSMFVFPFALPQYPFFFENTLHYSAAQYGLIISADGLAMALFPLVLGRLSDTLPKKPLVIIGSLLSASLNLAMLFLHQYPLLIVSSLMTGVGFALLMPSMSTIYLQATSDKNRSQLMGIRSTAISFAMLAAPLAQAAIAPWITPQITFAISSVLSLLMVIFAIVALKSPRQSSPEDASKIAA
>CP035758.1|QBD75749.1|1507982_1508516_-|HNH-endonuclease
MILSRYIEQFQGGKVDNSILIPLAIVIAVLIVGYIFLRPKRKRHYSRRRLPLPTLRRDYGAHIAKKHGRERSAEWERVAREHRLREPACVACGYRGHKLQVHHIKPFHLHPELELDPNNLITLCEARGREHHLLLGHLGAWDSYNEHIRADIKHFYRKTAAQIRADVNWLKKMQLRP
>CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase
MGKKYILFDHDGVLVDTEFWYYKAGERALADIGFTLDKDQYLRDMKDGLGAWAQARAAGIDEQTISRQREIRNAYYQEYLRTEAIEIEGVVETLAELAKYVRMAIVTTAKRVDFEIIHEKRQITQFMEFVLVREDYQLAKPHPEPYLTGLKRLGATKEETLVVEDSSRGLTSAVAAGIDCAIVSNDFTKAQDFSQASYRIETLIELKDIILQGT
>CP035758.1|QBD75757.1|1522114_1522402_-|hypothetical-protein
MKRYGIIFVAAGLLIGGFIGSLIPFGHGSALGIGCIVGGLLCAFLVDWKWRKIIAPPDATLTREQMEATHNNSYEAEVQMQHTGSDWRSGIGGLR
>CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein
MVNEEQQHVLYIIACAAGAAVQLYDHIPLLQADGWQVCVILTPSATGFVENERLTQLTGHPVRSSYKRPGDPDVLPPADALLVFPATFNTINKWALGISDNLALGLLCEFTGMKVPILAVPVVRKGKLAEHPAFGRSLKLLEEYGVHIFYHPELYPPRNEVPGGMLVSEVRKLKGDM
>CP035758.1|QBD75759.1|1526060_1526387_-|hypothetical-protein
MAQNEPTRRRYVDQAQEILQGTLEELDRSTRHRPPTLIVDVATTYALQGKKGQALQYALQAAQSLSETRFISRVPVLRLQSLQAFLCHVGASPTELGALDEAMKHLPL
>CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase
MAAPALLPTEGSRVLAILAHPDDAEFLCGGTIARLVEEGYEVHYLLVTRGEKGSDDPEMTAARLAEIREHEQRKAAFALGVQSVTFLEGYVDGEVEVTLTLRRELVWHVRKLRPNVVLTFDPWKKDEPHPDHRAVGMCTLDALACARGRMYFPEQLVDGTGPHRVKDIYYFSTDRPNHWVDITSVIDKKIAALRCHACQMLNFDPEEYIRRKGSQAGAEHKYKYAEMFHRAVF
>CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator
MSDVSHYGKYRSGLYGLPHMGEVIADYRVKRGWKSQGAFAIVCGVDRQTVAYWEKLEYLAEMKRRIFLCKVLRIPPMLLGLTWRSILDDAPAGCYADAPEHIKDLLHENAYGLYEDILMFAHTSLDRYSMTASYRFYKHLRELEELVHQSPGSEKENWQDLLSRFHQHAINIAQHHEQDAQALGHAEQAVELATSLQDKELLSSALYRRSRVHLTQHRHNKAREDIQAALSLAEHARGPLKGSCYLLRAEIEALFGEGDEKIKLQCRKWQDAAANLIYKGKVEPDETFLTFSLYAVHHERAKTLTRFALYHTTDDELVALLKQPHRRAKKELLRDAQESLLTAEKHLQQNNLPIGMYLPLTEAKCYLVDREFEKSAKTAKQALQYARVASSQQGIVETTRLYNMLSELAPNNPYICNLGVELGLY
>CP035758.1|QBD75762.1|1529026_1529281_+|hypothetical-protein
MSNASNNQSCPPTQQTILTVLGRLNQAYRAYNPSLPSHMRVQLTTTFYQHYRWLLSWRIPFRFDQVQRCYLPLASLYNSMSGAY
>CP035758.1|QBD75763.1|1529346_1529598_+|hypothetical-protein
MKNAGEGGLKPSRQTILIVLDALSRAKMVLPIAQLAYEKEKLTETIRACVAWLDHYQVAYHYDKTCHMYVLDLPAEKQEGAEP
>CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator
MKPVCLLPALEPAVGSILVADDSPTVRKILEYTLRREGYLVRAFPDGVSMLRWLHGGGSVPRLIFLDLVMPRMDGYQVASHLRKQAAYAGTILVLHTRCNGLLDRLKARLIGIEGYLAKPSTTQQILSLAGHYCSPPLPEEVLWP
>CP035758.1|QBD75765.1|1530086_1530371_+|hypothetical-protein
MGQHREYLWVVDVVPAGEDGWDWSQLVRVYAVDEAQARTRAEQRLEQLAPFAWQLERLRCCPHGFLLYRRRYPGSRLVDDETGEIIEEQQQENS

Crispr_ID: CP035758_7

• CRISPR_ID: CP035758_7
• CRISPR_location: 1521920-1522031
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers
• Cas_protein_info: csa3

Consensus repeat of CP035758_7

Consensus_repeat	Method
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	CRISPRCasFinder

spacers of CP035758_7

>7.1|1521957|37|CP035758|CRISPRCasFinder
AACCCCTTATTTGCTTGTAGCAACCAATCCTCGAAAT

CRISPR arrays and Neighbor proteins around CP035758_7

CRISPR arrays

The CRISPR arrays of CP035758_7

>merge|CP035758|7|1521920-1522031|CRISPRCasFinder
CTTGCAGTGCCCTCAAAACGGGCCATATCTCCTTAACAACCCCTTATTTGCTTGTAGCAACCAATCCTCGAAATCTTGCAGAACCCTCAAAGCGGGCCATATCTCCTTAACA

>CP035758|7|6|1521920-1522031|CRISPRCasFinder
CTTGCAGTGCCCTCAAAACGGGCCATATCTCCTTAAC	AACCCCTTATTTGCTTGTAGCAACCAATCCTCGAAAT
CTTGCAGAACCCTCAAAGCGGGCCATATCTCCTTAACA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|372595
CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133399
CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
CP035758.1|QBD75762.1|1529026_1529281_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274680
CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase	unknown	unknown	gnl|CDD|225031
CP035758.1|QBD75766.1|1530590_1531838_+|ATP-binding-protein	unknown	unknown	gnl|CDD|365803
CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl|CDD|379079
CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224393
CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein	unknown	unknown	gnl|CDD|319914
CP035758.1|QBD75759.1|1526060_1526387_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein	unknown	unknown	gnl|CDD|235986
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
CP035758.1|QBD75750.1|1508612_1509938_-|MFS-transporter	unknown	unknown	gnl|CDD|340883
CP035758.1|QBD75763.1|1529346_1529598_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75765.1|1530086_1530371_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187585
CP035758.1|QBD75757.1|1522114_1522402_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator	unknown	unknown	gnl|CDD|333815

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	1.7e-20	68.3	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase	gnl|CDD|372595	pfam13419, HAD_2, Haloacid dehalogenase-like hydrolase.	4.93133e-33
CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator	gnl|CDD|133399	cd04772, HTH_TioE_rpt1, First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE. Putative helix-turn-helix (HTH) regulatory protein, TioE, and related proteins. TioE is part of the thiocoraline gene cluster, which is involved in the biosynthesis of the antitumor thiocoraline from the marine actinomycete, Micromonospora. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Proteins in this family are unique within the MerR superfamily in that they are composed of just two adjacent MerR-like N-terminal domains; this CD contains the N-terminal or first repeat (rpt1) of these tandem MerR-like domain proteins.	4.54058e-14
CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.19268e-68
CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	5.7507e-41
CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase	gnl|CDD|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	2.53934e-42
CP035758.1|QBD75766.1|1530590_1531838_+|ATP-binding-protein	gnl|CDD|365803	pfam00004, AAA, ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.	2.40632e-28
CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein	gnl|CDD|379079	pfam13229, Beta_helix, Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	3.04827e-15
CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator	gnl|CDD|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	0.00377578
CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein	gnl|CDD|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.84308e-35
CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.48211e-32
CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein	gnl|CDD|235986	PRK07313, PRK07313, phosphopantothenoylcysteine decarboxylase; Validated.	3.01045e-17
CP035758.1|QBD75750.1|1508612_1509938_-|MFS-transporter	gnl|CDD|340883	cd17325, MFS_MdtG_SLC18_like, bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters. This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.29004e-65
CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator	gnl|CDD|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	4.39206e-22
CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase	gnl|CDD|187585	cd05324, carb_red_PTCR-like_SDR_c, Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs. PTCR is a classical SDR which catalyzes the NADPH-dependent reduction of ketones on steroids and prostaglandins. Unlike most SDRs, PTCR functions as a monomer. This subgroup also includes human carbonyl reductase 1 (CBR1) and CBR3. CBR1 is an NADPH-dependent SDR with broad substrate specificity and may be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds. In addition it includes poppy NADPH-dependent salutaridine reductase which catalyzes the stereospecific reduction of salutaridine to 7(S)-salutaridinol in the biosynthesis of morphine, and Arabidopsis SDR1,a menthone reductase, which catalyzes the reduction of menthone to neomenthol, a compound with antimicrobial activity; SDR1 can also carry out neomenthol oxidation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.92932e-89
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	5.7578e-18

Protein sequences

>CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase
MGKKYILFDHDGVLVDTEFWYYKAGERALADIGFTLDKDQYLRDMKDGLGAWAQARAAGIDEQTISRQREIRNAYYQEYLRTEAIEIEGVVETLAELAKYVRMAIVTTAKRVDFEIIHEKRQITQFMEFVLVREDYQLAKPHPEPYLTGLKRLGATKEETLVVEDSSRGLTSAVAAGIDCAIVSNDFTKAQDFSQASYRIETLIELKDIILQGT
>CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator
MASRPLRTSDIARELGVHVNTIRLYESWGYFSDIPRGTNGYRQFSTLHLEQARLAHLTLSTPYLGDKNLLIDLVKYAAHGDFAQALEQAYRYLAYVRMEITTTEAALEFLERWAVGQIRETTHQKMHIRQAAQYLNVTVDMLRNWERNGLITVPRDSSNGYRLYGPSEFGRIRVIRTLVQSGYSLMAILRMLQQFDAGHTENLHATLEIPREESDVEYIEIIADRWHSTLLELENRAQAIIRQLGSLIEMTHAS
>CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein
MPQHQFYVAPQGKDCWPGTYAQPFATLQQAQQHVRANTANQRSDIIVNLRAGTYFLATPLQFLAASGDSGEHGYDVIYQAYGYGTNKQEHVVLSGGREISGWQPYDEDSAIWQAEVGDLNTRQLFVDGQQAQRASLPSIPTLTRTETGYVVHDTTPQSWRSPADIEFVYQGIYPWSSARCGVASITGDQHSTTITMDQPAFSWANQLYTVEGRDRANWTGLGSPTAIENSVSFLTQPGTFALDRSRPGHHILFYMPRPGEDLARVSVIAPLLETLVSGQGTAEAPLHNLSLRGITFAHATWLQPSKPEGFLHYHGITYYNGGHIETVIYDPETQSSVTVPSDPARMPGNVTFSSATHILIEGCRFSHLGANALEFSKDCQDNLIRGNVIHDVSAAGIVIGTGASSRENRGNRIENNWVHHTGLEYHGSPAIYLAETQDSTIVHNQINDVPHCGIVVYGGSTARNTSVLNNLVFNTMKVLADGGGIYISSNQGASFASGTVVRGNVIHDTITSYNFGLYVDYGASWVTMQANVVYNSDTPTALQVEPPLQHVAFIGNFWDMNPDGYDNPPEYVTVAGNTRLPRDGFEPALLDNPASADIVTNAGLEPSYLHLLQM
>CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator
MESSVLDIPKMTRLLTALGEPARLEIIDQLAKQEQMNVGDLASKFSLSRPTISHHLKILKEAGVVQAEKSGQETYYRVNRDMLILGLQDIADTLKRCWTHTEP
>CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase
MPQPQKIALITGANQGIGLEVARQLGKQNILVLIGSRNWTRGKEAAQQLVAERIEAQAIQLDVTDQQSIEEAARQINDSYGRLDILVNNAAIAPVQDSQPKERPLDKIRAIFETNVFGLFAVTQAMLPLLHRSSAGRIVNVSSGLASLGTLSNAPAAALRPFSWPYPSSKTAVNSITIFLAKQLEQSAIKVNAVDPGRTATAMNPQATRTPAQAAQTIVHYATLASDGPSGGFFGEAGSLPW
>CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450
MVTDTAVPRPRSSLPGPQGLPLLGAKMHLLQLYLHPFVRLRELYTTYGDIVVLTRNNPMLVFAFGPQHNFSLLSNPDLFYASSEKSFEKVPRGTAFTHILRNNLQHLDGEPHQRQRHLMMPAFHERQIVNYHRDIVEQTQSLLDSWGIGRELDLAREMQRLTQNVVDKTLFGLADDEKVARLRAQIHKLTKVMALGAGLPIDFPGLPYRQALQLAQKFATEMRELIEQKRGQAEATDMLTVLSQSHDEVGEKLTDDQVIGQVFAFYTTAYQTIANALTWTNFLLMQHPHILANLLAELDEKLHGAPPTSAQLSQLPLLEGVIKEGLRLFPPAIIGKRIAMSTCELGGYELAAGTTIVYSEFLTHRLPELYTEPNRFRPERWLTLEPSPYEYLPFSAGQHRCIAAPFAMQELKIVLAIMLQRYRLALRPNLKLSVDFTMRAKPGMPVRIFAQDRQFKRTPVRGPILDMLEGI
>CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator
MPEKLPISQEGATKASDNAPPLPKLLASSQELGWEGIAVQAYHEPAELEWSGPGSPDSSLILVARGSLHMEHRPVNGSWSGKSFYQGDLLLQPGVTTASELHWKGLSSEPLHLLYIHLSQELLSRTAQELTKHDPARLDLIGHAGFHDPLLSQLALALWRELEQSAPAGKLYGQAAAQMLAVHLLRHYTAFSIDIQERSQGFTPRQMNHLVDFILAHLSENLSLETLAQQVGFSPYHFARLFQETTGKSPHQFVKQQRIERAKKLLRETDVPLAQVALESGFSNQSHLTRVFKHHLNLTPRVYRHDRSISAPF
>CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein
MKPRVTVITLGVNDLEKSLQFYRDGLGLPTQGIIGREFEHGALALFDLQHGLKLAIYPRNDLAFDAKVPLSVPNATECTVGHYLKNKAEVDAVMEQARQAGALITDQAHDRPWGIYSGYFQDPDGHLWEVVWDPRFETEIIE
>CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase
MQYGIHVPIFGPYGEVRVLADLAHEAEEAGWDGIFLWDQVSRTTLSPTLDPMIDPWIALTAIALRTHTIRLGPLVALLPRRRPWIIARQTLSLDHLSSGRLILGVGSGGSYFDFEALGEATDPKTLAGMLDESLEVLTGLWRGEPYRFEGKYYHIKEAQFLPRPVQSPRIPIWVAGEWPAKAPMRRAARWDGVAPLGRNISLTAMLTPEQMEEMVNYVRSQPGYSAPFEVVHSGFTSGTNRAKDRDIVAAYQQVGVTWWIEKILPERWGSWTDWPLEAMRQRIRSGPPR
>CP035758.1|QBD75750.1|1508612_1509938_-|MFS-transporter
MHTMSSEHEKTNTADLGRADVTSTGQHVDRKKRINKSLFILPASLALIMTGFGIIIPVYPQRLEALGLGAETLALMEGGFGLGMFLFSTPMGVWANRFGRKPLVLLALLGFVATNLLLAFVNIPAFFIAIRFLEGILVAGFMPAAMAMIGDAIPPEKQGRWMGVMTTAQAGGVALGPAIGGVLYQSWGFTSPFLLSAAFALASALLAIFMLPETLPEQVRAEALANRDRKKRGEKELDVNRVSLIHLAWAFAALLFIDFGSMFVFPFALPQYPFFFENTLHYSAAQYGLIISADGLAMALFPLVLGRLSDTLPKKPLVIIGSLLSASLNLAMLFLHQYPLLIVSSLMTGVGFALLMPSMSTIYLQATSDKNRSQLMGIRSTAISFAMLAAPLAQAAIAPWITPQITFAISSVLSLLMVIFAIVALKSPRQSSPEDASKIAA
>CP035758.1|QBD75757.1|1522114_1522402_-|hypothetical-protein
MKRYGIIFVAAGLLIGGFIGSLIPFGHGSALGIGCIVGGLLCAFLVDWKWRKIIAPPDATLTREQMEATHNNSYEAEVQMQHTGSDWRSGIGGLR
>CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein
MVNEEQQHVLYIIACAAGAAVQLYDHIPLLQADGWQVCVILTPSATGFVENERLTQLTGHPVRSSYKRPGDPDVLPPADALLVFPATFNTINKWALGISDNLALGLLCEFTGMKVPILAVPVVRKGKLAEHPAFGRSLKLLEEYGVHIFYHPELYPPRNEVPGGMLVSEVRKLKGDM
>CP035758.1|QBD75759.1|1526060_1526387_-|hypothetical-protein
MAQNEPTRRRYVDQAQEILQGTLEELDRSTRHRPPTLIVDVATTYALQGKKGQALQYALQAAQSLSETRFISRVPVLRLQSLQAFLCHVGASPTELGALDEAMKHLPL
>CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase
MAAPALLPTEGSRVLAILAHPDDAEFLCGGTIARLVEEGYEVHYLLVTRGEKGSDDPEMTAARLAEIREHEQRKAAFALGVQSVTFLEGYVDGEVEVTLTLRRELVWHVRKLRPNVVLTFDPWKKDEPHPDHRAVGMCTLDALACARGRMYFPEQLVDGTGPHRVKDIYYFSTDRPNHWVDITSVIDKKIAALRCHACQMLNFDPEEYIRRKGSQAGAEHKYKYAEMFHRAVF
>CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator
MSDVSHYGKYRSGLYGLPHMGEVIADYRVKRGWKSQGAFAIVCGVDRQTVAYWEKLEYLAEMKRRIFLCKVLRIPPMLLGLTWRSILDDAPAGCYADAPEHIKDLLHENAYGLYEDILMFAHTSLDRYSMTASYRFYKHLRELEELVHQSPGSEKENWQDLLSRFHQHAINIAQHHEQDAQALGHAEQAVELATSLQDKELLSSALYRRSRVHLTQHRHNKAREDIQAALSLAEHARGPLKGSCYLLRAEIEALFGEGDEKIKLQCRKWQDAAANLIYKGKVEPDETFLTFSLYAVHHERAKTLTRFALYHTTDDELVALLKQPHRRAKKELLRDAQESLLTAEKHLQQNNLPIGMYLPLTEAKCYLVDREFEKSAKTAKQALQYARVASSQQGIVETTRLYNMLSELAPNNPYICNLGVELGLY
>CP035758.1|QBD75762.1|1529026_1529281_+|hypothetical-protein
MSNASNNQSCPPTQQTILTVLGRLNQAYRAYNPSLPSHMRVQLTTTFYQHYRWLLSWRIPFRFDQVQRCYLPLASLYNSMSGAY
>CP035758.1|QBD75763.1|1529346_1529598_+|hypothetical-protein
MKNAGEGGLKPSRQTILIVLDALSRAKMVLPIAQLAYEKEKLTETIRACVAWLDHYQVAYHYDKTCHMYVLDLPAEKQEGAEP
>CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator
MKPVCLLPALEPAVGSILVADDSPTVRKILEYTLRREGYLVRAFPDGVSMLRWLHGGGSVPRLIFLDLVMPRMDGYQVASHLRKQAAYAGTILVLHTRCNGLLDRLKARLIGIEGYLAKPSTTQQILSLAGHYCSPPLPEEVLWP
>CP035758.1|QBD75765.1|1530086_1530371_+|hypothetical-protein
MGQHREYLWVVDVVPAGEDGWDWSQLVRVYAVDEAQARTRAEQRLEQLAPFAWQLERLRCCPHGFLLYRRRYPGSRLVDDETGEIIEEQQQENS
>CP035758.1|QBD75766.1|1530590_1531838_+|ATP-binding-protein
MKQYELINEALRLPLSIIPYYVSQQLATLFPAKAIIETDDFFFNVEKYSEGEQCTIAPLLNQHNEVLHGWWEADYDFSAKEYKEGYLLRSAQNSWQEISWRGATFTLLTLHWILLEGNTSGRYWLLADTKQQAEHFMEEVCRWNSEIRNEILVYNNGCWDKDAHLFQAIKNVSLDNLVLQGTLKEDIFSDLQGFFAMREVYQSYTIPWKRGILFIGPPGNGKTHTVKALINALDKPCIYVKSFKTDGDDNEQNINQVFARTRKVAPCLLILEDLDSLITDENRAYFLNELDGFASNDGIVILATTNHPQEIDPAILDRPSRFDRKYHFELPALTERTRYIKLWNASLHDQMRLSEQTIVALAEAAQDFSFAYLKELFLSSIMRWMAVPQTGMDKLVFEQVELLKKQMLSAASYST

Crispr_ID: CP035758_8

• CRISPR_ID: CP035758_8
• CRISPR_location: 1522490-1523046
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 7 spacers
• Cas_protein_info: csa3

Consensus repeat of CP035758_8

Consensus_repeat	Method
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	CRISPRCasFinder
CTTGCAGAATCCTCAAAGCGGGCCATCTCACCTTAAC	PILER-CR

spacers of CP035758_8

>8.1|1522527|37|CP035758|CRISPRCasFinder
ACCGACTGAGGAAGATTCTTGCAGCTGCTCTACTTGT
>8.2|1522601|37|CP035758|CRISPRCasFinder
TCCTTCTTCTCGCCTGGCTGAGTACGCTCGATCTACA
>8.3|1522675|40|CP035758|CRISPRCasFinder
CCATTCATGCTGTAGTTGCTGCTCATATTAAGCAGCTGCA
>8.4|1522752|36|CP035758|CRISPRCasFinder
ATCTGTTTTTCAACCCGGCACGCCGTCGAGAGAAGC
>8.5|1522825|39|CP035758|CRISPRCasFinder
TGCGCGATTTCCTCATTGCGCGCGGTGTAACCTGCTACG
>8.6|1522901|35|CP035758|CRISPRCasFinder
TGCAAACAGTGCTCTCTACCGATCCTGCTCTTCCT
>8.7|1522973|36|CP035758|CRISPRCasFinder
ATTAGTGCCGTCAACGATGTCGATATACCCTTGAGC
>8.8|1522543|48|CP035758|PILER-CR
GCCTCCTCAAGACCGACTGAGGAAGATTCTTGCAGCTGCTCTACTTGT
>8.9|1522635|30|CP035758|PILER-CR
TTCTCGCCTGGCTGAGTACGCTCGATCTAC

CRISPR arrays and Neighbor proteins around CP035758_8

CRISPR arrays

The CRISPR arrays of CP035758_8

>merge|CP035758|8|1522490-1523046|CRISPRCasFinder,PILER-CR
TTGCGACCCTCCTCAAAGCGGACCATGCCTCCTCAAGACCGACTGAGGAAGATTCTTGCAGCTGCTCTACTTGTCTTGCAGAACCCTCAAAGCGGGCCATCTCACCTTAACTCCTTCTTCTCGCCTGGCTGAGTACGCTCGATCTACACTTGCAGAATCCTCAAAGCGGGCCATCTCACCTTAACCCATTCATGCTGTAGTTGCTGCTCATATTAAGCAGCTGCACTTGCAGTACCCTCAAAGCGGGTCATGCCTCCTCAAGATCTGTTTTTCAACCCGGCACGCCGTCGAGAGAAGCCTTGCAGTACCCTCAAAGCGGGTCATCTCACCCTAACTGCGCGATTTCCTCATTGCGCGCGGTGTAACCTGCTACGCTTGCAGTACCCTGAAAGCGGGCCATGTCTCCTTAACTGCAAACAGTGCTCTCTACCGATCCTGCTCTTCCTCTTGCAGTATCCTCAAAGCGAGCCATATCTCCTTAACATTAGTGCCGTCAACGATGTCGATATACCCTTGAGCCTTGCAGTACCCTGAAAACGGGCCAAGCCTCCTCAACT

>CP035758|8|7|1522490-1523046|CRISPRCasFinder
TTGCGACCCTCCTCAAAGCGGACCATGCCTCCTCAAG	ACCGACTGAGGAAGATTCTTGCAGCTGCTCTACTTGT
CTTGCAGAACCCTCAAAGCGGGCCATCTCACCTTAAC	TCCTTCTTCTCGCCTGGCTGAGTACGCTCGATCTACA
CTTGCAGAATCCTCAAAGCGGGCCATCTCACCTTAAC	CCATTCATGCTGTAGTTGCTGCTCATATTAAGCAGCTGCA
CTTGCAGTACCCTCAAAGCGGGTCATGCCTCCTCAAG	ATCTGTTTTTCAACCCGGCACGCCGTCGAGAGAAGC
CTTGCAGTACCCTCAAAGCGGGTCATCTCACCCTAAC	TGCGCGATTTCCTCATTGCGCGCGGTGTAACCTGCTACG
CTTGCAGTACCCTGAAAGCGGGCCATGTCTCCTTAAC	TGCAAACAGTGCTCTCTACCGATCCTGCTCTTCCT
CTTGCAGTATCCTCAAAGCGAGCCATATCTCCTTAAC	ATTAGTGCCGTCAACGATGTCGATATACCCTTGAGC
CTTGCAGTACCCTGAAAACGGGCCAAGCCTCCTCAACT

>CP035758|8|3|1522499-1522674|PILER-CR
TCCTCAAAGCGGACCATGCCTCCTCAAGACCGACTGAGGAAGAT	TCTTGCAGCTGCTCTACTTGTCTTGCAGAACCCTCAAAGCGGGCCATC
TCACCTTAACTCCTTCTTCTCGCCTGGCTGAGTACGCTCGATCT	ACACTTGCAGAATCCTCAAAGCGGGCCATC
TCACCTTAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|372595
CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133399
CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
CP035758.1|QBD75762.1|1529026_1529281_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274680
CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase	unknown	unknown	gnl|CDD|225031
CP035758.1|QBD75766.1|1530590_1531838_+|ATP-binding-protein	unknown	unknown	gnl|CDD|365803
CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl|CDD|379079
CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224393
CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein	unknown	unknown	gnl|CDD|319914
CP035758.1|QBD75759.1|1526060_1526387_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein	unknown	unknown	gnl|CDD|235986
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
CP035758.1|QBD75763.1|1529346_1529598_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75767.1|1531825_1532302_-|ATPase	unknown	unknown	gnl|CDD|176904
CP035758.1|QBD75765.1|1530086_1530371_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187585
CP035758.1|QBD75757.1|1522114_1522402_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator	unknown	unknown	gnl|CDD|333815

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	1.7e-20	68.3	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase	gnl|CDD|372595	pfam13419, HAD_2, Haloacid dehalogenase-like hydrolase.	4.93133e-33
CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator	gnl|CDD|133399	cd04772, HTH_TioE_rpt1, First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE. Putative helix-turn-helix (HTH) regulatory protein, TioE, and related proteins. TioE is part of the thiocoraline gene cluster, which is involved in the biosynthesis of the antitumor thiocoraline from the marine actinomycete, Micromonospora. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Proteins in this family are unique within the MerR superfamily in that they are composed of just two adjacent MerR-like N-terminal domains; this CD contains the N-terminal or first repeat (rpt1) of these tandem MerR-like domain proteins.	4.54058e-14
CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.19268e-68
CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	5.7507e-41
CP035758.1|QBD75766.1|1530590_1531838_+|ATP-binding-protein	gnl|CDD|365803	pfam00004, AAA, ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.	2.40632e-28
CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein	gnl|CDD|379079	pfam13229, Beta_helix, Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	3.04827e-15
CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein	gnl|CDD|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.84308e-35
CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase	gnl|CDD|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	2.53934e-42
CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.48211e-32
CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein	gnl|CDD|235986	PRK07313, PRK07313, phosphopantothenoylcysteine decarboxylase; Validated.	3.01045e-17
CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator	gnl|CDD|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	4.39206e-22
CP035758.1|QBD75767.1|1531825_1532302_-|ATPase	gnl|CDD|176904	cd08895, SRPBCC_CalC_Aha1-like_2, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	2.52137e-59
CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase	gnl|CDD|187585	cd05324, carb_red_PTCR-like_SDR_c, Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs. PTCR is a classical SDR which catalyzes the NADPH-dependent reduction of ketones on steroids and prostaglandins. Unlike most SDRs, PTCR functions as a monomer. This subgroup also includes human carbonyl reductase 1 (CBR1) and CBR3. CBR1 is an NADPH-dependent SDR with broad substrate specificity and may be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds. In addition it includes poppy NADPH-dependent salutaridine reductase which catalyzes the stereospecific reduction of salutaridine to 7(S)-salutaridinol in the biosynthesis of morphine, and Arabidopsis SDR1,a menthone reductase, which catalyzes the reduction of menthone to neomenthol, a compound with antimicrobial activity; SDR1 can also carry out neomenthol oxidation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.92932e-89
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	5.7578e-18
CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator	gnl|CDD|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	0.00377578

Protein sequences

>CP035758.1|QBD75757.1|1522114_1522402_-|hypothetical-protein
MKRYGIIFVAAGLLIGGFIGSLIPFGHGSALGIGCIVGGLLCAFLVDWKWRKIIAPPDATLTREQMEATHNNSYEAEVQMQHTGSDWRSGIGGLR
>CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase
MGKKYILFDHDGVLVDTEFWYYKAGERALADIGFTLDKDQYLRDMKDGLGAWAQARAAGIDEQTISRQREIRNAYYQEYLRTEAIEIEGVVETLAELAKYVRMAIVTTAKRVDFEIIHEKRQITQFMEFVLVREDYQLAKPHPEPYLTGLKRLGATKEETLVVEDSSRGLTSAVAAGIDCAIVSNDFTKAQDFSQASYRIETLIELKDIILQGT
>CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator
MASRPLRTSDIARELGVHVNTIRLYESWGYFSDIPRGTNGYRQFSTLHLEQARLAHLTLSTPYLGDKNLLIDLVKYAAHGDFAQALEQAYRYLAYVRMEITTTEAALEFLERWAVGQIRETTHQKMHIRQAAQYLNVTVDMLRNWERNGLITVPRDSSNGYRLYGPSEFGRIRVIRTLVQSGYSLMAILRMLQQFDAGHTENLHATLEIPREESDVEYIEIIADRWHSTLLELENRAQAIIRQLGSLIEMTHAS
>CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein
MPQHQFYVAPQGKDCWPGTYAQPFATLQQAQQHVRANTANQRSDIIVNLRAGTYFLATPLQFLAASGDSGEHGYDVIYQAYGYGTNKQEHVVLSGGREISGWQPYDEDSAIWQAEVGDLNTRQLFVDGQQAQRASLPSIPTLTRTETGYVVHDTTPQSWRSPADIEFVYQGIYPWSSARCGVASITGDQHSTTITMDQPAFSWANQLYTVEGRDRANWTGLGSPTAIENSVSFLTQPGTFALDRSRPGHHILFYMPRPGEDLARVSVIAPLLETLVSGQGTAEAPLHNLSLRGITFAHATWLQPSKPEGFLHYHGITYYNGGHIETVIYDPETQSSVTVPSDPARMPGNVTFSSATHILIEGCRFSHLGANALEFSKDCQDNLIRGNVIHDVSAAGIVIGTGASSRENRGNRIENNWVHHTGLEYHGSPAIYLAETQDSTIVHNQINDVPHCGIVVYGGSTARNTSVLNNLVFNTMKVLADGGGIYISSNQGASFASGTVVRGNVIHDTITSYNFGLYVDYGASWVTMQANVVYNSDTPTALQVEPPLQHVAFIGNFWDMNPDGYDNPPEYVTVAGNTRLPRDGFEPALLDNPASADIVTNAGLEPSYLHLLQM
>CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator
MESSVLDIPKMTRLLTALGEPARLEIIDQLAKQEQMNVGDLASKFSLSRPTISHHLKILKEAGVVQAEKSGQETYYRVNRDMLILGLQDIADTLKRCWTHTEP
>CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase
MPQPQKIALITGANQGIGLEVARQLGKQNILVLIGSRNWTRGKEAAQQLVAERIEAQAIQLDVTDQQSIEEAARQINDSYGRLDILVNNAAIAPVQDSQPKERPLDKIRAIFETNVFGLFAVTQAMLPLLHRSSAGRIVNVSSGLASLGTLSNAPAAALRPFSWPYPSSKTAVNSITIFLAKQLEQSAIKVNAVDPGRTATAMNPQATRTPAQAAQTIVHYATLASDGPSGGFFGEAGSLPW
>CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450
MVTDTAVPRPRSSLPGPQGLPLLGAKMHLLQLYLHPFVRLRELYTTYGDIVVLTRNNPMLVFAFGPQHNFSLLSNPDLFYASSEKSFEKVPRGTAFTHILRNNLQHLDGEPHQRQRHLMMPAFHERQIVNYHRDIVEQTQSLLDSWGIGRELDLAREMQRLTQNVVDKTLFGLADDEKVARLRAQIHKLTKVMALGAGLPIDFPGLPYRQALQLAQKFATEMRELIEQKRGQAEATDMLTVLSQSHDEVGEKLTDDQVIGQVFAFYTTAYQTIANALTWTNFLLMQHPHILANLLAELDEKLHGAPPTSAQLSQLPLLEGVIKEGLRLFPPAIIGKRIAMSTCELGGYELAAGTTIVYSEFLTHRLPELYTEPNRFRPERWLTLEPSPYEYLPFSAGQHRCIAAPFAMQELKIVLAIMLQRYRLALRPNLKLSVDFTMRAKPGMPVRIFAQDRQFKRTPVRGPILDMLEGI
>CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator
MPEKLPISQEGATKASDNAPPLPKLLASSQELGWEGIAVQAYHEPAELEWSGPGSPDSSLILVARGSLHMEHRPVNGSWSGKSFYQGDLLLQPGVTTASELHWKGLSSEPLHLLYIHLSQELLSRTAQELTKHDPARLDLIGHAGFHDPLLSQLALALWRELEQSAPAGKLYGQAAAQMLAVHLLRHYTAFSIDIQERSQGFTPRQMNHLVDFILAHLSENLSLETLAQQVGFSPYHFARLFQETTGKSPHQFVKQQRIERAKKLLRETDVPLAQVALESGFSNQSHLTRVFKHHLNLTPRVYRHDRSISAPF
>CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein
MKPRVTVITLGVNDLEKSLQFYRDGLGLPTQGIIGREFEHGALALFDLQHGLKLAIYPRNDLAFDAKVPLSVPNATECTVGHYLKNKAEVDAVMEQARQAGALITDQAHDRPWGIYSGYFQDPDGHLWEVVWDPRFETEIIE
>CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase
MQYGIHVPIFGPYGEVRVLADLAHEAEEAGWDGIFLWDQVSRTTLSPTLDPMIDPWIALTAIALRTHTIRLGPLVALLPRRRPWIIARQTLSLDHLSSGRLILGVGSGGSYFDFEALGEATDPKTLAGMLDESLEVLTGLWRGEPYRFEGKYYHIKEAQFLPRPVQSPRIPIWVAGEWPAKAPMRRAARWDGVAPLGRNISLTAMLTPEQMEEMVNYVRSQPGYSAPFEVVHSGFTSGTNRAKDRDIVAAYQQVGVTWWIEKILPERWGSWTDWPLEAMRQRIRSGPPR
>CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein
MVNEEQQHVLYIIACAAGAAVQLYDHIPLLQADGWQVCVILTPSATGFVENERLTQLTGHPVRSSYKRPGDPDVLPPADALLVFPATFNTINKWALGISDNLALGLLCEFTGMKVPILAVPVVRKGKLAEHPAFGRSLKLLEEYGVHIFYHPELYPPRNEVPGGMLVSEVRKLKGDM
>CP035758.1|QBD75759.1|1526060_1526387_-|hypothetical-protein
MAQNEPTRRRYVDQAQEILQGTLEELDRSTRHRPPTLIVDVATTYALQGKKGQALQYALQAAQSLSETRFISRVPVLRLQSLQAFLCHVGASPTELGALDEAMKHLPL
>CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase
MAAPALLPTEGSRVLAILAHPDDAEFLCGGTIARLVEEGYEVHYLLVTRGEKGSDDPEMTAARLAEIREHEQRKAAFALGVQSVTFLEGYVDGEVEVTLTLRRELVWHVRKLRPNVVLTFDPWKKDEPHPDHRAVGMCTLDALACARGRMYFPEQLVDGTGPHRVKDIYYFSTDRPNHWVDITSVIDKKIAALRCHACQMLNFDPEEYIRRKGSQAGAEHKYKYAEMFHRAVF
>CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator
MSDVSHYGKYRSGLYGLPHMGEVIADYRVKRGWKSQGAFAIVCGVDRQTVAYWEKLEYLAEMKRRIFLCKVLRIPPMLLGLTWRSILDDAPAGCYADAPEHIKDLLHENAYGLYEDILMFAHTSLDRYSMTASYRFYKHLRELEELVHQSPGSEKENWQDLLSRFHQHAINIAQHHEQDAQALGHAEQAVELATSLQDKELLSSALYRRSRVHLTQHRHNKAREDIQAALSLAEHARGPLKGSCYLLRAEIEALFGEGDEKIKLQCRKWQDAAANLIYKGKVEPDETFLTFSLYAVHHERAKTLTRFALYHTTDDELVALLKQPHRRAKKELLRDAQESLLTAEKHLQQNNLPIGMYLPLTEAKCYLVDREFEKSAKTAKQALQYARVASSQQGIVETTRLYNMLSELAPNNPYICNLGVELGLY
>CP035758.1|QBD75762.1|1529026_1529281_+|hypothetical-protein
MSNASNNQSCPPTQQTILTVLGRLNQAYRAYNPSLPSHMRVQLTTTFYQHYRWLLSWRIPFRFDQVQRCYLPLASLYNSMSGAY
>CP035758.1|QBD75763.1|1529346_1529598_+|hypothetical-protein
MKNAGEGGLKPSRQTILIVLDALSRAKMVLPIAQLAYEKEKLTETIRACVAWLDHYQVAYHYDKTCHMYVLDLPAEKQEGAEP
>CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator
MKPVCLLPALEPAVGSILVADDSPTVRKILEYTLRREGYLVRAFPDGVSMLRWLHGGGSVPRLIFLDLVMPRMDGYQVASHLRKQAAYAGTILVLHTRCNGLLDRLKARLIGIEGYLAKPSTTQQILSLAGHYCSPPLPEEVLWP
>CP035758.1|QBD75765.1|1530086_1530371_+|hypothetical-protein
MGQHREYLWVVDVVPAGEDGWDWSQLVRVYAVDEAQARTRAEQRLEQLAPFAWQLERLRCCPHGFLLYRRRYPGSRLVDDETGEIIEEQQQENS
>CP035758.1|QBD75766.1|1530590_1531838_+|ATP-binding-protein
MKQYELINEALRLPLSIIPYYVSQQLATLFPAKAIIETDDFFFNVEKYSEGEQCTIAPLLNQHNEVLHGWWEADYDFSAKEYKEGYLLRSAQNSWQEISWRGATFTLLTLHWILLEGNTSGRYWLLADTKQQAEHFMEEVCRWNSEIRNEILVYNNGCWDKDAHLFQAIKNVSLDNLVLQGTLKEDIFSDLQGFFAMREVYQSYTIPWKRGILFIGPPGNGKTHTVKALINALDKPCIYVKSFKTDGDDNEQNINQVFARTRKVAPCLLILEDLDSLITDENRAYFLNELDGFASNDGIVILATTNHPQEIDPAILDRPSRFDRKYHFELPALTERTRYIKLWNASLHDQMRLSEQTIVALAEAAQDFSFAYLKELFLSSIMRWMAVPQTGMDKLVFEQVELLKKQMLSAASYST
>CP035758.1|QBD75767.1|1531825_1532302_-|ATPase
MTNADSHASTRNEKFIKATPEALYRAFTDPSALAIWFAPGDMTGKVDHFDYRVGGGYQMSLYYPSTEITMRGKSAEREDRYTARFVELTPPERIVEAITFDTTNPDFSGEMSMEVTFEARNEGTNVSILFKNIPPGIRPEDNETGTQLTLEKLARYVE

Crispr_ID: CP035758_9

• CRISPR_ID: CP035758_9
• CRISPR_location: 1523146-1524580
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 19 spacers
• Cas_protein_info: csa3

Consensus repeat of CP035758_9

Consensus_repeat	Method
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	CRISPRCasFinder
CTTGCAGTACCCTNAAAGCGGGCCATNNCTCCTNAA	CRT
CTTGCAGTACCCTGAAAACGGGCCAT	PILER-CR
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	PILER-CR

spacers of CP035758_9

>9.1|1523183|35|CP035758|CRISPRCasFinder
GACTTTGCCAGAGGCGAGGCGAGCAAAGGCTACGG
>9.2|1523255|37|CP035758|CRISPRCasFinder
AGAACTGTTATTCGATGAATACAAGCTGTACGACATG
>9.3|1523329|38|CP035758|CRISPRCasFinder
GCTGGTAAGGGCTAGCATCAGCGGCGACCATTAATTTC
>9.4|1523404|35|CP035758|CRISPRCasFinder
TCAACTCGCTGAAAGTGTCCGCAAAAATGATATGT
>9.5|1523476|38|CP035758|CRISPRCasFinder
CAAAATCCTCCTCTGCTTCTTCCTTCGACTCAGATCCG
>9.6|1523551|39|CP035758|CRISPRCasFinder
AACGCGGTATACCGTAATGTACGCCTCGATTGTTCCATA
>9.7|1523627|35|CP035758|CRISPRCasFinder
TGGGTTGTATCAAATGATTGATAGGCTCGCGGAGT
>9.8|1523699|35|CP035758|CRISPRCasFinder
CATATGATACTGCCAACTCCCGTATCACCCTTGCA
>9.9|1523771|35|CP035758|CRISPRCasFinder
CAAATCGTTGGCGCTATATGCCTCTTTGGCGAACA
>9.10|1523843|38|CP035758|CRISPRCasFinder
TCAAGCAGGAACGCATAGAGACGATCCTCCGTGGACGA
>9.11|1523918|35|CP035758|CRISPRCasFinder
GACGCTTCCTTGCTCCTGCATCAGCAGTTACAGGA
>9.12|1523990|37|CP035758|CRISPRCasFinder
GCAGAAGCACGAGGCTTTAATCAATCCTCATTATCAC
>9.13|1524064|37|CP035758|CRISPRCasFinder
ATTGGATATGCACGTTACAAAGAAATGCAGCAGGAGC
>9.14|1524138|37|CP035758|CRISPRCasFinder,PILER-CR
ATGAGCGATAAAATACCAGAGCCCCGTTATGCCACAT
>9.15|1524212|37|CP035758|CRISPRCasFinder,PILER-CR
TTTGCTCTAAGCGAGTATCACACAGGTCCCGTTCCGG
>9.16|1524286|37|CP035758|CRISPRCasFinder,PILER-CR
GGTGTGGTTATTGGTTAATGGTGTCGAGACTGTACAG
>9.17|1524360|37|CP035758|CRISPRCasFinder,PILER-CR
GGCTTAAGGACGCTCATCGTGATATCACTGGACTCTG
>9.18|1524434|35|CP035758|CRISPRCasFinder,PILER-CR
ACCAGAAGAAAACCTGATGTGCTTAAGGCAGTAGT
>9.19|1524506|38|CP035758|CRISPRCasFinder,PILER-CR
AGGTAGATCTAAAAAATGTTCAGACCCTCAATGTCCAG
>9.20|1523182|36|CP035758|CRT
CGACTTTGCCAGAGGCGAGGCGAGCAAAGGCTACGG
>9.21|1523254|38|CP035758|CRT
CAGAACTGTTATTCGATGAATACAAGCTGTACGACATG
>9.22|1523328|39|CP035758|CRT
CGCTGGTAAGGGCTAGCATCAGCGGCGACCATTAATTTC
>9.23|1523403|36|CP035758|CRT
CTCAACTCGCTGAAAGTGTCCGCAAAAATGATATGT
>9.24|1523475|39|CP035758|CRT
GCAAAATCCTCCTCTGCTTCTTCCTTCGACTCAGATCCG
>9.25|1523550|40|CP035758|CRT
CAACGCGGTATACCGTAATGTACGCCTCGATTGTTCCATA
>9.26|1523626|36|CP035758|CRT
CTGGGTTGTATCAAATGATTGATAGGCTCGCGGAGT
>9.27|1523698|36|CP035758|CRT
CCATATGATACTGCCAACTCCCGTATCACCCTTGCA
>9.28|1523770|36|CP035758|CRT
CCAAATCGTTGGCGCTATATGCCTCTTTGGCGAACA
>9.29|1523842|39|CP035758|CRT
CTCAAGCAGGAACGCATAGAGACGATCCTCCGTGGACGA
>9.30|1523917|36|CP035758|CRT
CGACGCTTCCTTGCTCCTGCATCAGCAGTTACAGGA
>9.31|1523989|38|CP035758|CRT
CGCAGAAGCACGAGGCTTTAATCAATCCTCATTATCAC
>9.32|1524063|38|CP035758|CRT
CATTGGATATGCACGTTACAAAGAAATGCAGCAGGAGC
>9.33|1524137|38|CP035758|CRT
GATGAGCGATAAAATACCAGAGCCCCGTTATGCCACAT
>9.34|1524211|38|CP035758|CRT
GTTTGCTCTAAGCGAGTATCACACAGGTCCCGTTCCGG
>9.35|1524285|38|CP035758|CRT
GGGTGTGGTTATTGGTTAATGGTGTCGAGACTGTACAG
>9.36|1524359|38|CP035758|CRT
GGGCTTAAGGACGCTCATCGTGATATCACTGGACTCTG
>9.37|1524433|36|CP035758|CRT
GACCAGAAGAAAACCTGATGTGCTTAAGGCAGTAGT
>9.38|1524505|39|CP035758|CRT
GAGGTAGATCTAAAAAATGTTCAGACCCTCAATGTCCAG
>9.39|1523540|50|CP035758|PILER-CR
CCCTCCTTAACAACGCGGTATACCGTAATGTACGCCTCGATTGTTCCATA
>9.40|1523616|46|CP035758|PILER-CR
CCCTCCTCAACTGGGTTGTATCAAATGATTGATAGGCTCGCGGAGT
>9.41|1523688|46|CP035758|PILER-CR
ATCTCCTTAACCATATGATACTGCCAACTCCCGTATCACCCTTGCA
>9.42|1523760|46|CP035758|PILER-CR
ATCTCCTTAACCAAATCGTTGGCGCTATATGCCTCTTTGGCGAACA
>9.43|1523832|49|CP035758|PILER-CR
CTCACCTTAACTCAAGCAGGAACGCATAGAGACGATCCTCCGTGGACGA

CRISPR arrays and Neighbor proteins around CP035758_9

CRISPR arrays

The CRISPR arrays of CP035758_9

>merge|CP035758|9|1523146-1524580|CRISPRCasFinder,CRT,PILER-CR,PILER-CR
CTTGCAGTACCCTGAAAACGGGCCATCTCACCTTAACGACTTTGCCAGAGGCGAGGCGAGCAAAGGCTACGGCTTGCAGTACCCTGAAAGCGGGCCATCTCACCTTAACAGAACTGTTATTCGATGAATACAAGCTGTACGACATGCTTGCAGAATCCTCAAAGCGGGCCATCTCTTCTCAACGCTGGTAAGGGCTAGCATCAGCGGCGACCATTAATTTCCTTGCAGTACCCTGAAAGCGGGCCATCTCACCTTAACTCAACTCGCTGAAAGTGTCCGCAAAAATGATATGTCTAGCAGTACCCACAAAATGGGCCATGCCTCCTCAAGCAAAATCCTCCTCTGCTTCTTCCTTCGACTCAGATCCGCTTGCAGTACCCTGAAAGCGGGCCATCCCTCCTTAACAACGCGGTATACCGTAATGTACGCCTCGATTGTTCCATACTTGCAGTACCCTGAAAGCGGGCCATCCCTCCTCAACTGGGTTGTATCAAATGATTGATAGGCTCGCGGAGTCTAGCAGTACCCTGAAAGCGGGCCATATCTCCTTAACCATATGATACTGCCAACTCCCGTATCACCCTTGCACTTGCAGTACCCTGAAAACGGGCCATATCTCCTTAACCAAATCGTTGGCGCTATATGCCTCTTTGGCGAACACTTGCAGTACCCTGAAAACGGGCCATCTCACCTTAACTCAAGCAGGAACGCATAGAGACGATCCTCCGTGGACGACTTGCAGTACCCTGAAAACGGGCCAAGCCTCCTCAACGACGCTTCCTTGCTCCTGCATCAGCAGTTACAGGACTAGCAGTGCCCTCAAAGCGTGCCATATCTCCCTAACGCAGAAGCACGAGGCTTTAATCAATCCTCATTATCACCTTGCAGTGCCCTCAAAGCGTGCCATATCTCCTTAACATTGGATATGCACGTTACAAAGAAATGCAGCAGGAGCCTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAGATGAGCGATAAAATACCAGAGCCCCGTTATGCCACATCTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAGTTTGCTCTAAGCGAGTATCACACAGGTCCCGTTCCGGCTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAGGGTGTGGTTATTGGTTAATGGTGTCGAGACTGTACAGCTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAGGGCTTAAGGACGCTCATCGTGATATCACTGGACTCTGCTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAGACCAGAAGAAAACCTGATGTGCTTAAGGCAGTAGTCTAGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAGAGGTAGATCTAAAAAATGTTCAGACCCTCAATGTCCAGCTAGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG

>CP035758|9|8|1523146-1524580|CRISPRCasFinder
CTTGCAGTACCCTGAAAACGGGCCATCTCACCTTAAC	GACTTTGCCAGAGGCGAGGCGAGCAAAGGCTACGG
CTTGCAGTACCCTGAAAGCGGGCCATCTCACCTTAAC	AGAACTGTTATTCGATGAATACAAGCTGTACGACATG
CTTGCAGAATCCTCAAAGCGGGCCATCTCTTCTCAAC	GCTGGTAAGGGCTAGCATCAGCGGCGACCATTAATTTC
CTTGCAGTACCCTGAAAGCGGGCCATCTCACCTTAAC	TCAACTCGCTGAAAGTGTCCGCAAAAATGATATGT
CTAGCAGTACCCACAAAATGGGCCATGCCTCCTCAAG	CAAAATCCTCCTCTGCTTCTTCCTTCGACTCAGATCCG
CTTGCAGTACCCTGAAAGCGGGCCATCCCTCCTTAAC	AACGCGGTATACCGTAATGTACGCCTCGATTGTTCCATA
CTTGCAGTACCCTGAAAGCGGGCCATCCCTCCTCAAC	TGGGTTGTATCAAATGATTGATAGGCTCGCGGAGT
CTAGCAGTACCCTGAAAGCGGGCCATATCTCCTTAAC	CATATGATACTGCCAACTCCCGTATCACCCTTGCA
CTTGCAGTACCCTGAAAACGGGCCATATCTCCTTAAC	CAAATCGTTGGCGCTATATGCCTCTTTGGCGAACA
CTTGCAGTACCCTGAAAACGGGCCATCTCACCTTAAC	TCAAGCAGGAACGCATAGAGACGATCCTCCGTGGACGA
CTTGCAGTACCCTGAAAACGGGCCAAGCCTCCTCAAC	GACGCTTCCTTGCTCCTGCATCAGCAGTTACAGGA
CTAGCAGTGCCCTCAAAGCGTGCCATATCTCCCTAAC	GCAGAAGCACGAGGCTTTAATCAATCCTCATTATCAC
CTTGCAGTGCCCTCAAAGCGTGCCATATCTCCTTAAC	ATTGGATATGCACGTTACAAAGAAATGCAGCAGGAGC
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	ATGAGCGATAAAATACCAGAGCCCCGTTATGCCACAT
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	TTTGCTCTAAGCGAGTATCACACAGGTCCCGTTCCGG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	GGTGTGGTTATTGGTTAATGGTGTCGAGACTGTACAG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	GGCTTAAGGACGCTCATCGTGATATCACTGGACTCTG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	ACCAGAAGAAAACCTGATGTGCTTAAGGCAGTAGT
CTAGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	AGGTAGATCTAAAAAATGTTCAGACCCTCAATGTCCAG
CTAGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG

>CP035758|9|2|1523146-1524579|CRT
CTTGCAGTACCCTGAAAACGGGCCATCTCACCTTAA	CGACTTTGCCAGAGGCGAGGCGAGCAAAGGCTACGG
CTTGCAGTACCCTGAAAGCGGGCCATCTCACCTTAA	CAGAACTGTTATTCGATGAATACAAGCTGTACGACATG
CTTGCAGAATCCTCAAAGCGGGCCATCTCTTCTCAA	CGCTGGTAAGGGCTAGCATCAGCGGCGACCATTAATTTC
CTTGCAGTACCCTGAAAGCGGGCCATCTCACCTTAA	CTCAACTCGCTGAAAGTGTCCGCAAAAATGATATGT
CTAGCAGTACCCACAAAATGGGCCATGCCTCCTCAA	GCAAAATCCTCCTCTGCTTCTTCCTTCGACTCAGATCCG
CTTGCAGTACCCTGAAAGCGGGCCATCCCTCCTTAA	CAACGCGGTATACCGTAATGTACGCCTCGATTGTTCCATA
CTTGCAGTACCCTGAAAGCGGGCCATCCCTCCTCAA	CTGGGTTGTATCAAATGATTGATAGGCTCGCGGAGT
CTAGCAGTACCCTGAAAGCGGGCCATATCTCCTTAA	CCATATGATACTGCCAACTCCCGTATCACCCTTGCA
CTTGCAGTACCCTGAAAACGGGCCATATCTCCTTAA	CCAAATCGTTGGCGCTATATGCCTCTTTGGCGAACA
CTTGCAGTACCCTGAAAACGGGCCATCTCACCTTAA	CTCAAGCAGGAACGCATAGAGACGATCCTCCGTGGACGA
CTTGCAGTACCCTGAAAACGGGCCAAGCCTCCTCAA	CGACGCTTCCTTGCTCCTGCATCAGCAGTTACAGGA
CTAGCAGTGCCCTCAAAGCGTGCCATATCTCCCTAA	CGCAGAAGCACGAGGCTTTAATCAATCCTCATTATCAC
CTTGCAGTGCCCTCAAAGCGTGCCATATCTCCTTAA	CATTGGATATGCACGTTACAAAGAAATGCAGCAGGAGC
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAA	GATGAGCGATAAAATACCAGAGCCCCGTTATGCCACAT
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAA	GTTTGCTCTAAGCGAGTATCACACAGGTCCCGTTCCGG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAA	GGGTGTGGTTATTGGTTAATGGTGTCGAGACTGTACAG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAA	GGGCTTAAGGACGCTCATCGTGATATCACTGGACTCTG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAA	GACCAGAAGAAAACCTGATGTGCTTAAGGCAGTAGT
CTAGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAA	GAGGTAGATCTAAAAAATGTTCAGACCCTCAATGTCCAG
CTAGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAA

>CP035758|9|4|1523514-1523906|PILER-CR
CTTGCAGTACCCTGAAAGCGGGCCAT	CCCTCCTTAACAACGCGGTATACCGTAATGTACGCCTCGATTGTTCCATA
CTTGCAGTACCCTGAAAGCGGGCCAT	CCCTCCTCAACTGGGTTGTATCAAATGATTGATAGGCTCGCGGAGT
CTAGCAGTACCCTGAAAGCGGGCCAT	ATCTCCTTAACCATATGATACTGCCAACTCCCGTATCACCCTTGCA
CTTGCAGTACCCTGAAAACGGGCCAT	ATCTCCTTAACCAAATCGTTGGCGCTATATGCCTCTTTGGCGAACA
CTTGCAGTACCCTGAAAACGGGCCAT	CTCACCTTAACTCAAGCAGGAACGCATAGAGACGATCCTCCGTGGACGA
CTTGCAGTACCCTGAAAACGGGCCAAGCCTCCTCAACGACGCTTCCTTGCTCCTGCATCAGCAGTTACAGGACTAGCAGTGCCCTCAAAGCGTGCCATATCTCCCTAACGCAGAAGCACGAGGCTTTAATCAATCCTCATTATCACCTTGCAGTGCCCTCAAAGCGTGCCATATCTCCTTAACATTGGATATGCACGTTACAAAGAAATGCAGCAGGAGCCTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	ATGAGCGATAAAATACCAGAGCCCCGTTATGCCACAT
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	TTTGCTCTAAGCGAGTATCACACAGGTCCCGTTCCGG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	GGTGTGGTTATTGGTTAATGGTGTCGAGACTGTACAG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	GGCTTAAGGACGCTCATCGTGATATCACTGGACTCTG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	ACCAGAAGAAAACCTGATGTGCTTAAGGCAGTAGT
CTAGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	AGGTAGATCTAAAAAATGTTCAGACCCTCAATGTCCAG


>CP035758|9|5|1524101-1524580|PILER-CR
	CCCTCCTTAACAACGCGGTATACCGTAATGTACGCCTCGATTGTTCCATA
CTTGCAGTACCCTGAAAGCGGGCCAT	CCCTCCTCAACTGGGTTGTATCAAATGATTGATAGGCTCGCGGAGT
CTAGCAGTACCCTGAAAGCGGGCCAT	ATCTCCTTAACCATATGATACTGCCAACTCCCGTATCACCCTTGCA
CTTGCAGTACCCTGAAAACGGGCCAT	ATCTCCTTAACCAAATCGTTGGCGCTATATGCCTCTTTGGCGAACA
CTTGCAGTACCCTGAAAACGGGCCAT	CTCACCTTAACTCAAGCAGGAACGCATAGAGACGATCCTCCGTGGACGA
CTTGCAGTACCCTGAAAACGGGCCAAGCCTCCTCAACGACGCTTCCTTGCTCCTGCATCAGCAGTTACAGGACTAGCAGTGCCCTCAAAGCGTGCCATATCTCCCTAACGCAGAAGCACGAGGCTTTAATCAATCCTCATTATCACCTTGCAGTGCCCTCAAAGCGTGCCATATCTCCTTAACATTGGATATGCACGTTACAAAGAAATGCAGCAGGAGCCTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	ATGAGCGATAAAATACCAGAGCCCCGTTATGCCACAT
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	TTTGCTCTAAGCGAGTATCACACAGGTCCCGTTCCGG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	GGTGTGGTTATTGGTTAATGGTGTCGAGACTGTACAG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	GGCTTAAGGACGCTCATCGTGATATCACTGGACTCTG
CTTGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	ACCAGAAGAAAACCTGATGTGCTTAAGGCAGTAGT
CTAGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG	AGGTAGATCTAAAAAATGTTCAGACCCTCAATGTCCAG
CTAGCAGTACCCTCAAAGCGGGCCATGCCTCCTCAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase	unknown	unknown	gnl|CDD|372595
CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133399
CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450	unknown	unknown	gnl|CDD|225035
CP035758.1|QBD75762.1|1529026_1529281_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274680
CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase	unknown	unknown	gnl|CDD|225031
CP035758.1|QBD75766.1|1530590_1531838_+|ATP-binding-protein	unknown	unknown	gnl|CDD|365803
CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein	unknown	unknown	gnl|CDD|379079
CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224393
CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein	unknown	unknown	gnl|CDD|319914
CP035758.1|QBD75759.1|1526060_1526387_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225117
CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein	unknown	unknown	gnl|CDD|235986
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	gnl|CDD|238042
CP035758.1|QBD75763.1|1529346_1529598_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75767.1|1531825_1532302_-|ATPase	unknown	unknown	gnl|CDD|176904
CP035758.1|QBD75765.1|1530086_1530371_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187585
CP035758.1|QBD75757.1|1522114_1522402_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator	unknown	unknown	gnl|CDD|333815

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	csa3	COG0640_csa3_CAS-I-A	1.7e-20	68.3	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase	gnl|CDD|372595	pfam13419, HAD_2, Haloacid dehalogenase-like hydrolase.	4.93133e-33
CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator	gnl|CDD|133399	cd04772, HTH_TioE_rpt1, First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE. Putative helix-turn-helix (HTH) regulatory protein, TioE, and related proteins. TioE is part of the thiocoraline gene cluster, which is involved in the biosynthesis of the antitumor thiocoraline from the marine actinomycete, Micromonospora. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Proteins in this family are unique within the MerR superfamily in that they are composed of just two adjacent MerR-like N-terminal domains; this CD contains the N-terminal or first repeat (rpt1) of these tandem MerR-like domain proteins.	4.54058e-14
CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	2.19268e-68
CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274680	TIGR03619, F420_Rv2161c, probable F420-dependent oxidoreductase, Rv2161c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes a domain found in a distinctive subset of bacterial luciferase homologs, found only in F420-biosynthesizing members of the Actinobacteria. [Unknown function, Enzymes of unknown specificity].	5.7507e-41
CP035758.1|QBD75766.1|1530590_1531838_+|ATP-binding-protein	gnl|CDD|365803	pfam00004, AAA, ATPase family associated with various cellular activities (AAA). AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.	2.40632e-28
CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein	gnl|CDD|379079	pfam13229, Beta_helix, Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	3.04827e-15
CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein	gnl|CDD|319914	cd07251, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.84308e-35
CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase	gnl|CDD|225031	COG2120, COG2120, Uncharacterized proteins, LmbE homologs [Function unknown].	2.53934e-42
CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator	gnl|CDD|225117	COG2207, AraC, AraC-type DNA-binding domain-containing proteins [Transcription].	1.48211e-32
CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein	gnl|CDD|235986	PRK07313, PRK07313, phosphopantothenoylcysteine decarboxylase; Validated.	3.01045e-17
CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator	gnl|CDD|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	4.39206e-22
CP035758.1|QBD75767.1|1531825_1532302_-|ATPase	gnl|CDD|176904	cd08895, SRPBCC_CalC_Aha1-like_2, Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins. SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain of a functionally uncharacterized subgroup of CalC- and Aha1-like proteins. This group shows similarity to the SRPBCC domains of Micromonospora echinospora CalC (a protein which confers resistance to enediynes) and human Aha1 (one of several co-chaperones which regulate the dimeric chaperone Hsp90), and belongs to the SRPBCC domain superfamily of proteins that bind hydrophobic ligands. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands.	2.52137e-59
CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase	gnl|CDD|187585	cd05324, carb_red_PTCR-like_SDR_c, Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs. PTCR is a classical SDR which catalyzes the NADPH-dependent reduction of ketones on steroids and prostaglandins. Unlike most SDRs, PTCR functions as a monomer. This subgroup also includes human carbonyl reductase 1 (CBR1) and CBR3. CBR1 is an NADPH-dependent SDR with broad substrate specificity and may be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds. In addition it includes poppy NADPH-dependent salutaridine reductase which catalyzes the stereospecific reduction of salutaridine to 7(S)-salutaridinol in the biosynthesis of morphine, and Arabidopsis SDR1,a menthone reductase, which catalyzes the reduction of menthone to neomenthol, a compound with antimicrobial activity; SDR1 can also carry out neomenthol oxidation. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold (alpha/beta folding pattern with a central beta-sheet), an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Classical SDRs are typically about 250 residues long, while extended SDRs are approximately 350 residues. Sequence identity between different SDR enzymes are typically in the 15-30% range, but the enzymes share the Rossmann fold NAD-binding motif and characteristic NAD-binding and catalytic sequence patterns. These enzymes catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) numbering). In addition to the Tyr and Lys, there is often an upstream Ser (Ser-138, 15-PGDH numbering) and/or an Asn (Asn-107, 15-PGDH numbering) contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. Extended SDRs have additional elements in the C-terminal region, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif. Some atypical SDRs have lost catalytic activity and/or have an unusual NAD(P)-binding motif and missing or unusual active site residues. Reactions catalyzed within the SDR family include isomerization, decarboxylation, epimerization, C=N bond reduction, dehydratase activity, dehalogenation, Enoyl-CoA reduction, and carbonyl-alcohol oxidoreduction.	3.92932e-89
CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator	gnl|CDD|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	5.7578e-18
CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator	gnl|CDD|224393	COG1476, COG1476, Predicted transcriptional regulators [Transcription].	0.00377578

Protein sequences

>CP035758.1|QBD75757.1|1522114_1522402_-|hypothetical-protein
MKRYGIIFVAAGLLIGGFIGSLIPFGHGSALGIGCIVGGLLCAFLVDWKWRKIIAPPDATLTREQMEATHNNSYEAEVQMQHTGSDWRSGIGGLR
>CP035758.1|QBD83393.1|1521064_1521709_-|HAD-family-hydrolase
MGKKYILFDHDGVLVDTEFWYYKAGERALADIGFTLDKDQYLRDMKDGLGAWAQARAAGIDEQTISRQREIRNAYYQEYLRTEAIEIEGVVETLAELAKYVRMAIVTTAKRVDFEIIHEKRQITQFMEFVLVREDYQLAKPHPEPYLTGLKRLGATKEETLVVEDSSRGLTSAVAAGIDCAIVSNDFTKAQDFSQASYRIETLIELKDIILQGT
>CP035758.1|QBD75756.1|1519382_1520147_-|MerR-family-transcriptional-regulator
MASRPLRTSDIARELGVHVNTIRLYESWGYFSDIPRGTNGYRQFSTLHLEQARLAHLTLSTPYLGDKNLLIDLVKYAAHGDFAQALEQAYRYLAYVRMEITTTEAALEFLERWAVGQIRETTHQKMHIRQAAQYLNVTVDMLRNWERNGLITVPRDSSNGYRLYGPSEFGRIRVIRTLVQSGYSLMAILRMLQQFDAGHTENLHATLEIPREESDVEYIEIIADRWHSTLLELENRAQAIIRQLGSLIEMTHAS
>CP035758.1|QBD83392.1|1517341_1519186_-|right-handed-parallel-beta-helix-repeat-containing-protein
MPQHQFYVAPQGKDCWPGTYAQPFATLQQAQQHVRANTANQRSDIIVNLRAGTYFLATPLQFLAASGDSGEHGYDVIYQAYGYGTNKQEHVVLSGGREISGWQPYDEDSAIWQAEVGDLNTRQLFVDGQQAQRASLPSIPTLTRTETGYVVHDTTPQSWRSPADIEFVYQGIYPWSSARCGVASITGDQHSTTITMDQPAFSWANQLYTVEGRDRANWTGLGSPTAIENSVSFLTQPGTFALDRSRPGHHILFYMPRPGEDLARVSVIAPLLETLVSGQGTAEAPLHNLSLRGITFAHATWLQPSKPEGFLHYHGITYYNGGHIETVIYDPETQSSVTVPSDPARMPGNVTFSSATHILIEGCRFSHLGANALEFSKDCQDNLIRGNVIHDVSAAGIVIGTGASSRENRGNRIENNWVHHTGLEYHGSPAIYLAETQDSTIVHNQINDVPHCGIVVYGGSTARNTSVLNNLVFNTMKVLADGGGIYISSNQGASFASGTVVRGNVIHDTITSYNFGLYVDYGASWVTMQANVVYNSDTPTALQVEPPLQHVAFIGNFWDMNPDGYDNPPEYVTVAGNTRLPRDGFEPALLDNPASADIVTNAGLEPSYLHLLQM
>CP035758.1|QBD75755.1|1516689_1517001_-|ArsR-family-transcriptional-regulator
MESSVLDIPKMTRLLTALGEPARLEIIDQLAKQEQMNVGDLASKFSLSRPTISHHLKILKEAGVVQAEKSGQETYYRVNRDMLILGLQDIADTLKRCWTHTEP
>CP035758.1|QBD75754.1|1515864_1516593_-|SDR-family-oxidoreductase
MPQPQKIALITGANQGIGLEVARQLGKQNILVLIGSRNWTRGKEAAQQLVAERIEAQAIQLDVTDQQSIEEAARQINDSYGRLDILVNNAAIAPVQDSQPKERPLDKIRAIFETNVFGLFAVTQAMLPLLHRSSAGRIVNVSSGLASLGTLSNAPAAALRPFSWPYPSSKTAVNSITIFLAKQLEQSAIKVNAVDPGRTATAMNPQATRTPAQAAQTIVHYATLASDGPSGGFFGEAGSLPW
>CP035758.1|QBD83391.1|1514336_1515752_+|cytochrome-P450
MVTDTAVPRPRSSLPGPQGLPLLGAKMHLLQLYLHPFVRLRELYTTYGDIVVLTRNNPMLVFAFGPQHNFSLLSNPDLFYASSEKSFEKVPRGTAFTHILRNNLQHLDGEPHQRQRHLMMPAFHERQIVNYHRDIVEQTQSLLDSWGIGRELDLAREMQRLTQNVVDKTLFGLADDEKVARLRAQIHKLTKVMALGAGLPIDFPGLPYRQALQLAQKFATEMRELIEQKRGQAEATDMLTVLSQSHDEVGEKLTDDQVIGQVFAFYTTAYQTIANALTWTNFLLMQHPHILANLLAELDEKLHGAPPTSAQLSQLPLLEGVIKEGLRLFPPAIIGKRIAMSTCELGGYELAAGTTIVYSEFLTHRLPELYTEPNRFRPERWLTLEPSPYEYLPFSAGQHRCIAAPFAMQELKIVLAIMLQRYRLALRPNLKLSVDFTMRAKPGMPVRIFAQDRQFKRTPVRGPILDMLEGI
>CP035758.1|QBD75753.1|1513227_1514169_+|AraC-family-transcriptional-regulator
MPEKLPISQEGATKASDNAPPLPKLLASSQELGWEGIAVQAYHEPAELEWSGPGSPDSSLILVARGSLHMEHRPVNGSWSGKSFYQGDLLLQPGVTTASELHWKGLSSEPLHLLYIHLSQELLSRTAQELTKHDPARLDLIGHAGFHDPLLSQLALALWRELEQSAPAGKLYGQAAAQMLAVHLLRHYTAFSIDIQERSQGFTPRQMNHLVDFILAHLSENLSLETLAQQVGFSPYHFARLFQETTGKSPHQFVKQQRIERAKKLLRETDVPLAQVALESGFSNQSHLTRVFKHHLNLTPRVYRHDRSISAPF
>CP035758.1|QBD75752.1|1512474_1512903_+|VOC-family-protein
MKPRVTVITLGVNDLEKSLQFYRDGLGLPTQGIIGREFEHGALALFDLQHGLKLAIYPRNDLAFDAKVPLSVPNATECTVGHYLKNKAEVDAVMEQARQAGALITDQAHDRPWGIYSGYFQDPDGHLWEVVWDPRFETEIIE
>CP035758.1|QBD75751.1|1510799_1511669_+|LLM-class-flavin-dependent-oxidoreductase
MQYGIHVPIFGPYGEVRVLADLAHEAEEAGWDGIFLWDQVSRTTLSPTLDPMIDPWIALTAIALRTHTIRLGPLVALLPRRRPWIIARQTLSLDHLSSGRLILGVGSGGSYFDFEALGEATDPKTLAGMLDESLEVLTGLWRGEPYRFEGKYYHIKEAQFLPRPVQSPRIPIWVAGEWPAKAPMRRAARWDGVAPLGRNISLTAMLTPEQMEEMVNYVRSQPGYSAPFEVVHSGFTSGTNRAKDRDIVAAYQQVGVTWWIEKILPERWGSWTDWPLEAMRQRIRSGPPR
>CP035758.1|QBD75758.1|1525453_1525987_-|flavoprotein
MVNEEQQHVLYIIACAAGAAVQLYDHIPLLQADGWQVCVILTPSATGFVENERLTQLTGHPVRSSYKRPGDPDVLPPADALLVFPATFNTINKWALGISDNLALGLLCEFTGMKVPILAVPVVRKGKLAEHPAFGRSLKLLEEYGVHIFYHPELYPPRNEVPGGMLVSEVRKLKGDM
>CP035758.1|QBD75759.1|1526060_1526387_-|hypothetical-protein
MAQNEPTRRRYVDQAQEILQGTLEELDRSTRHRPPTLIVDVATTYALQGKKGQALQYALQAAQSLSETRFISRVPVLRLQSLQAFLCHVGASPTELGALDEAMKHLPL
>CP035758.1|QBD75760.1|1526740_1527442_+|PIG-L-family-deacetylase
MAAPALLPTEGSRVLAILAHPDDAEFLCGGTIARLVEEGYEVHYLLVTRGEKGSDDPEMTAARLAEIREHEQRKAAFALGVQSVTFLEGYVDGEVEVTLTLRRELVWHVRKLRPNVVLTFDPWKKDEPHPDHRAVGMCTLDALACARGRMYFPEQLVDGTGPHRVKDIYYFSTDRPNHWVDITSVIDKKIAALRCHACQMLNFDPEEYIRRKGSQAGAEHKYKYAEMFHRAVF
>CP035758.1|QBD75761.1|1527517_1528795_-|XRE-family-transcriptional-regulator
MSDVSHYGKYRSGLYGLPHMGEVIADYRVKRGWKSQGAFAIVCGVDRQTVAYWEKLEYLAEMKRRIFLCKVLRIPPMLLGLTWRSILDDAPAGCYADAPEHIKDLLHENAYGLYEDILMFAHTSLDRYSMTASYRFYKHLRELEELVHQSPGSEKENWQDLLSRFHQHAINIAQHHEQDAQALGHAEQAVELATSLQDKELLSSALYRRSRVHLTQHRHNKAREDIQAALSLAEHARGPLKGSCYLLRAEIEALFGEGDEKIKLQCRKWQDAAANLIYKGKVEPDETFLTFSLYAVHHERAKTLTRFALYHTTDDELVALLKQPHRRAKKELLRDAQESLLTAEKHLQQNNLPIGMYLPLTEAKCYLVDREFEKSAKTAKQALQYARVASSQQGIVETTRLYNMLSELAPNNPYICNLGVELGLY
>CP035758.1|QBD75762.1|1529026_1529281_+|hypothetical-protein
MSNASNNQSCPPTQQTILTVLGRLNQAYRAYNPSLPSHMRVQLTTTFYQHYRWLLSWRIPFRFDQVQRCYLPLASLYNSMSGAY
>CP035758.1|QBD75763.1|1529346_1529598_+|hypothetical-protein
MKNAGEGGLKPSRQTILIVLDALSRAKMVLPIAQLAYEKEKLTETIRACVAWLDHYQVAYHYDKTCHMYVLDLPAEKQEGAEP
>CP035758.1|QBD75764.1|1529594_1530032_+|response-regulator
MKPVCLLPALEPAVGSILVADDSPTVRKILEYTLRREGYLVRAFPDGVSMLRWLHGGGSVPRLIFLDLVMPRMDGYQVASHLRKQAAYAGTILVLHTRCNGLLDRLKARLIGIEGYLAKPSTTQQILSLAGHYCSPPLPEEVLWP
>CP035758.1|QBD75765.1|1530086_1530371_+|hypothetical-protein
MGQHREYLWVVDVVPAGEDGWDWSQLVRVYAVDEAQARTRAEQRLEQLAPFAWQLERLRCCPHGFLLYRRRYPGSRLVDDETGEIIEEQQQENS
>CP035758.1|QBD75766.1|1530590_1531838_+|ATP-binding-protein
MKQYELINEALRLPLSIIPYYVSQQLATLFPAKAIIETDDFFFNVEKYSEGEQCTIAPLLNQHNEVLHGWWEADYDFSAKEYKEGYLLRSAQNSWQEISWRGATFTLLTLHWILLEGNTSGRYWLLADTKQQAEHFMEEVCRWNSEIRNEILVYNNGCWDKDAHLFQAIKNVSLDNLVLQGTLKEDIFSDLQGFFAMREVYQSYTIPWKRGILFIGPPGNGKTHTVKALINALDKPCIYVKSFKTDGDDNEQNINQVFARTRKVAPCLLILEDLDSLITDENRAYFLNELDGFASNDGIVILATTNHPQEIDPAILDRPSRFDRKYHFELPALTERTRYIKLWNASLHDQMRLSEQTIVALAEAAQDFSFAYLKELFLSSIMRWMAVPQTGMDKLVFEQVELLKKQMLSAASYST
>CP035758.1|QBD75767.1|1531825_1532302_-|ATPase
MTNADSHASTRNEKFIKATPEALYRAFTDPSALAIWFAPGDMTGKVDHFDYRVGGGYQMSLYYPSTEITMRGKSAEREDRYTARFVELTPPERIVEAITFDTTNPDFSGEMSMEVTFEARNEGTNVSILFKNIPPGIRPEDNETGTQLTLEKLARYVE

Crispr_ID: CP035758_10

• CRISPR_ID: CP035758_10
• CRISPR_location: 1706280-1707347
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 14 spacers

Consensus repeat of CP035758_10

Consensus_repeat	Method
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	CRISPRCasFinder
GTAGCAGGGAGGAAGNACCGTTAGAGGTTACTGTAAG	CRT
CTTACAGTAACCTCTAACGGTCCTTCCTCCCTGCTAC	PILER-CR

spacers of CP035758_10

>10.1|1706317|37|CP035758|CRISPRCasFinder,CRT
ATAGGCTTGTTCACAAAGCAGCAACGCACGGAGGTAA
>10.2|1706391|37|CP035758|CRISPRCasFinder,CRT
CGTTAATGGGGATCTCTGGGATCTGTTTTTCAACCCG
>10.3|1706465|38|CP035758|CRISPRCasFinder,CRT,PILER-CR
GATAATGTGAGCGCTATTGTCGTGCAGACGTATACTGC
>10.4|1706540|37|CP035758|CRISPRCasFinder,CRT,PILER-CR
CTCCGATAGCAGGGAGTGGTCAAGGACGAGTAGCGAC
>10.5|1706614|36|CP035758|CRISPRCasFinder,CRT,PILER-CR
AGCCAGGAGAATGCTATGGCAATCAAGCATACAAAG
>10.6|1706687|35|CP035758|CRISPRCasFinder,CRT,PILER-CR
CTCCTGGTCATTGCCGAAGGCATCTCTCTTCGTGA
>10.7|1706759|37|CP035758|CRISPRCasFinder,CRT,PILER-CR
TTCTGCCTGTTAATCGTAAGACTACTGAAACATCATA
>10.8|1706833|38|CP035758|CRISPRCasFinder,CRT
TGCTACGCATCGCTTACCGTATCATCTCAAGCAGCAGC
>10.9|1706908|38|CP035758|CRISPRCasFinder,CRT
ACAAAGAGGCTGATGCGAGAGCTTACAGGATAGGGTGT
>10.10|1706983|36|CP035758|CRISPRCasFinder,CRT
CCACTTTGTTGACCACCCGAATAGCCCACTAATTGA
>10.11|1707056|40|CP035758|CRISPRCasFinder,CRT
GCCAATAGCGAATCACATATCGGTAGCATTGTTCCCGCTG
>10.12|1707133|34|CP035758|CRISPRCasFinder,CRT
TTGGCTTCTTCAAAGAGACGCGGCTGCTCTTCTA
>10.13|1707204|29|CP035758|CRISPRCasFinder,CRT
TCCTTATCCACAGCATCTTTTGGAAGATT
>10.14|1707270|41|CP035758|CRISPRCasFinder,CRT
CCTTCAATAATGGGTACGCGTGTCTCTCTTTTAGAGGTCTT

CRISPR arrays and Neighbor proteins around CP035758_10

CRISPR arrays

The CRISPR arrays of CP035758_10

>merge|CP035758|10|1706280-1707347|CRISPRCasFinder,CRT,PILER-CR
GTAGCAGGGAGGAAGAGCCGTTAGAGGTTACTGTAAAATAGGCTTGTTCACAAAGCAGCAACGCACGGAGGTAAGTAGCAGGGAGGAAGAACCGTTCGAGGGTACTGTAAGCGTTAATGGGGATCTCTGGGATCTGTTTTTCAACCCGGTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAGGATAATGTGAGCGCTATTGTCGTGCAGACGTATACTGCGTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAGCTCCGATAGCAGGGAGTGGTCAAGGACGAGTAGCGACGTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAGAGCCAGGAGAATGCTATGGCAATCAAGCATACAAAGGTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAGCTCCTGGTCATTGCCGAAGGCATCTCTCTTCGTGAGTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAGTTCTGCCTGTTAATCGTAAGACTACTGAAACATCATAGTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAGTGCTACGCATCGCTTACCGTATCATCTCAAGCAGCAGCGTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAGGACAAAGAGGCTGATGCGAGAGCTTACAGGATAGGGTGTCTAGCAGAGAGGAAGAGCCGTTAGCGGTTACTGTAAGCCACTTTGTTGACCACCCGAATAGCCCACTAATTGAGTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAGGCCAATAGCGAATCACATATCGGTAGCATTGTTCCCGCTGGTAGCAGAGAGGAAGAGCCGTTAGAGGGTACTGTAAGTTGGCTTCTTCAAAGAGACGCGGCTGCTCTTCTAGTAGCAGAGAGGAAGAGCCGTTAGAGGGTACTGTAAGTCCTTATCCACAGCATCTTTTGGAAGATTGTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAGCCTTCAATAATGGGTACGCGTGTCTCTCTTTTAGAGGTCTTGTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG

>CP035758|10|9|1706280-1707347|CRISPRCasFinder
GTAGCAGGGAGGAAGAGCCGTTAGAGGTTACTGTAAA	ATAGGCTTGTTCACAAAGCAGCAACGCACGGAGGTAA
GTAGCAGGGAGGAAGAACCGTTCGAGGGTACTGTAAG	CGTTAATGGGGATCTCTGGGATCTGTTTTTCAACCCG
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	GATAATGTGAGCGCTATTGTCGTGCAGACGTATACTGC
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	CTCCGATAGCAGGGAGTGGTCAAGGACGAGTAGCGAC
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	AGCCAGGAGAATGCTATGGCAATCAAGCATACAAAG
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	CTCCTGGTCATTGCCGAAGGCATCTCTCTTCGTGA
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	TTCTGCCTGTTAATCGTAAGACTACTGAAACATCATA
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	TGCTACGCATCGCTTACCGTATCATCTCAAGCAGCAGC
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAGG	ACAAAGAGGCTGATGCGAGAGCTTACAGGATAGGGTGT
CTAGCAGAGAGGAAGAGCCGTTAGCGGTTACTGTAAG	CCACTTTGTTGACCACCCGAATAGCCCACTAATTGA
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	GCCAATAGCGAATCACATATCGGTAGCATTGTTCCCGCTG
GTAGCAGAGAGGAAGAGCCGTTAGAGGGTACTGTAAG	TTGGCTTCTTCAAAGAGACGCGGCTGCTCTTCTA
GTAGCAGAGAGGAAGAGCCGTTAGAGGGTACTGTAAG	TCCTTATCCACAGCATCTTTTGGAAGATT
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	CCTTCAATAATGGGTACGCGTGTCTCTCTTTTAGAGGTCTT
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG

>CP035758|10|3|1706280-1707347|CRT
GTAGCAGGGAGGAAGAGCCGTTAGAGGTTACTGTAAA	ATAGGCTTGTTCACAAAGCAGCAACGCACGGAGGTAA
GTAGCAGGGAGGAAGAACCGTTCGAGGGTACTGTAAG	CGTTAATGGGGATCTCTGGGATCTGTTTTTCAACCCG
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	GATAATGTGAGCGCTATTGTCGTGCAGACGTATACTGC
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	CTCCGATAGCAGGGAGTGGTCAAGGACGAGTAGCGAC
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	AGCCAGGAGAATGCTATGGCAATCAAGCATACAAAG
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	CTCCTGGTCATTGCCGAAGGCATCTCTCTTCGTGA
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	TTCTGCCTGTTAATCGTAAGACTACTGAAACATCATA
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	TGCTACGCATCGCTTACCGTATCATCTCAAGCAGCAGC
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAGG	ACAAAGAGGCTGATGCGAGAGCTTACAGGATAGGGTGT
CTAGCAGAGAGGAAGAGCCGTTAGCGGTTACTGTAAG	CCACTTTGTTGACCACCCGAATAGCCCACTAATTGA
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	GCCAATAGCGAATCACATATCGGTAGCATTGTTCCCGCTG
GTAGCAGAGAGGAAGAGCCGTTAGAGGGTACTGTAAG	TTGGCTTCTTCAAAGAGACGCGGCTGCTCTTCTA
GTAGCAGAGAGGAAGAGCCGTTAGAGGGTACTGTAAG	TCCTTATCCACAGCATCTTTTGGAAGATT
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	CCTTCAATAATGGGTACGCGTGTCTCTCTTTTAGAGGTCTT
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG

>CP035758|10|6|1706428-1706832|PILER-CR
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	GATAATGTGAGCGCTATTGTCGTGCAGACGTATACTGC
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	CTCCGATAGCAGGGAGTGGTCAAGGACGAGTAGCGAC
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	AGCCAGGAGAATGCTATGGCAATCAAGCATACAAAG
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	CTCCTGGTCATTGCCGAAGGCATCTCTCTTCGTGA
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG	TTCTGCCTGTTAATCGTAAGACTACTGAAACATCATA
GTAGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD75931.1|1712537_1712768_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75933.1|1714711_1715815_-|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|274368
CP035758.1|QBD75928.1|1709818_1710244_+|transcriptional-regulator	unknown	unknown	gnl|CDD|224647
CP035758.1|QBD75925.1|1704838_1705900_+|hypothetical-protein	unknown	unknown	gnl|CDD|224513
CP035758.1|QBD75927.1|1707726_1708467_+|IS3-family-transposase	unknown	unknown	gnl|CDD|222853
CP035758.1|QBD75918.1|1695876_1696170_+|Dabb-family-protein	unknown	unknown	gnl|CDD|214884
CP035758.1|QBD75924.1|1704333_1704558_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75930.1|1711744_1712188_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
CP035758.1|QBD75923.1|1701797_1702610_+|serine-protein-kinase-RIO	unknown	unknown	gnl|CDD|270696
CP035758.1|QBD75922.1|1700035_1701214_-|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|107206
CP035758.1|QBD75920.1|1699206_1699425_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD83399.1|1703323_1704070_+|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
CP035758.1|QBD75926.1|1707451_1707754_+|transposase	unknown	unknown	gnl|CDD|225511
CP035758.1|QBD75935.1|1716722_1717001_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75934.1|1715811_1716501_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
CP035758.1|QBD75929.1|1710735_1711611_-|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274648
CP035758.1|QBD75921.1|1699472_1699850_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75917.1|1693951_1695880_+|hypothetical-protein	unknown	unknown	gnl|CDD|198111
CP035758.1|QBD75932.1|1712828_1713944_-|epoxide-hydrolase	unknown	unknown	gnl|CDD|377658
CP035758.1|QBD75919.1|1696420_1697122_-|PIG-L-family-deacetylase	unknown	unknown	gnl|CDD|376836

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD75933.1|1714711_1715815_-|HAMP-domain-containing-protein	gnl|CDD|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	6.63895e-54
CP035758.1|QBD75928.1|1709818_1710244_+|transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.09886e-37
CP035758.1|QBD75925.1|1704838_1705900_+|hypothetical-protein	gnl|CDD|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	4.41039e-34
CP035758.1|QBD75927.1|1707726_1708467_+|IS3-family-transposase	gnl|CDD|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.37614e-43
CP035758.1|QBD75918.1|1695876_1696170_+|Dabb-family-protein	gnl|CDD|214884	smart00886, Dabb, Stress responsive A/B Barrel Domain. The function of this domain is unknown, but it is upregulated in response to salt stress in Populus balsamifera (balsam poplar). It is also found at the C-terminus of a fructose 1,6-bisphosphate aldolase from Hydrogenophilus thermoluteolus.It is found in the pA01 plasmid, which encodes genes for molybdopterin uptake and degradation of plant alkaloid nicotine. The structure of one has been solved and the domain forms an alpha-beta barrel dimer. Although there is a clear duplication within the domain it is not obviously detectable in the sequence.	1.54778e-19
CP035758.1|QBD75930.1|1711744_1712188_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.74621e-22
CP035758.1|QBD75923.1|1701797_1702610_+|serine-protein-kinase-RIO	gnl|CDD|270696	cd05145, RIO1_like, Catalytic domain of the atypical protein serine kinases, RIO1 and RIO3 kinases and similar proteins. RIO1 is present in archaea, bacteria and eukaryotes. In addition, RIO3 is present in multicellular eukaryotes. Both RIO1 and RIO3 are associated with precursors of 40S ribosomal subunits, just like RIO2. RIO1 is essential for survival and is required for 18S rRNA processing, proper cell cycle progression and chromosome maintenance. Although depletion of either RIO1 and RIO2 results in similar effects, the two kinases are not fully interchangeable. The specific function of RIO3 is unknown. RIO kinases are atypical protein serine kinases containing a kinase catalytic signature, but otherwise show very little sequence similarity to typical PKs. Serine kinases catalyze the transfer of the gamma-phosphoryl group from ATP to serine residues in protein substrates. The RIO catalytic domain is truncated compared to the catalytic domains of typical PKs, with deletions of the loops responsible for substrate binding. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).	2.21253e-49
CP035758.1|QBD75922.1|1700035_1701214_-|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|107206	cd01563, Thr-synth_1, Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.	1.95796e-115
CP035758.1|QBD83399.1|1703323_1704070_+|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	8.94427e-27
CP035758.1|QBD75926.1|1707451_1707754_+|transposase	gnl|CDD|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.15954e-07
CP035758.1|QBD75934.1|1715811_1716501_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.14222e-82
CP035758.1|QBD75929.1|1710735_1711611_-|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274648	TIGR03560, F420_Rv1855c, probable F420-dependent oxidoreductase, Rv1855c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity].	2.10496e-79
CP035758.1|QBD75917.1|1693951_1695880_+|hypothetical-protein	gnl|CDD|198111	smart01043, BTAD, Bacterial transcriptional activator domain. Found in the DNRI/REDD/AFSR family of regulators. This region of AFSR along with the C terminal region is capable of independently directing actinorhodin production. This family contains TPR repeats.	5.43274e-14
CP035758.1|QBD75932.1|1712828_1713944_-|epoxide-hydrolase	gnl|CDD|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	3.0733e-53
CP035758.1|QBD75919.1|1696420_1697122_-|PIG-L-family-deacetylase	gnl|CDD|376836	pfam02585, PIG-L, GlcNAc-PI de-N-acetylase. Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyzes the second step in GPI biosynthesis.	1.04872e-37

Protein sequences

>CP035758.1|QBD75925.1|1704838_1705900_+|hypothetical-protein
MKKALLIHSPGSGKSALLSQTIEGLQAAGIEVVEHIPISALGDGAAGRWAEQELDFVVAAGGDGLIGGLLSHVIGCKLPLGIIPLGTANDVARSVGIPLEIQAAAEAMASSVVREIDIGAAHPGLDEAEPAQGDEKSRKRASLLFAHALTVGINAQFARQATSSSVREQYGALTYPFALKEAVRTYAPIDVELRFHGLVEWSADGSCVTMTEEELSLSCRAAQATVVNAPIFWGPLQATVPGVSLRDRVLDIVVVEDASLQDLMLRLARFFNRQEQRPALPADWHARYPELLAAQRTDIPGIHHVQARGVTIATRGKCQDVTLDGEIACQTPVYARVAAERLRLLVPDPQAVV
>CP035758.1|QBD75924.1|1704333_1704558_+|hypothetical-protein
MQSQPVSRLLSRTELSNVSPSVTLQSQDQPALLAEQQASHSECLLEDSPDQQLESTGRAFERLFTRLFCRGLLF
>CP035758.1|QBD83399.1|1703323_1704070_+|PadR-family-transcriptional-regulator
MSRFFAMRGKRGFGPQGPFGPQDQGDLFGPGGPFGPEVPHGPRGPFGPRGPHGHHQRGQGPFEGRHFFGRGDVKYALLALMQERPMHGYEMMKALEERSNGLYVPSAGTIYPTLQMLEDRGLISVQEVEGKKVYSITDDGRKALADRQQEEDQFAHPFWGRFGPHAHRWDSPEIHALRSEAAGVAQLFVAAARQVFFDESKAQRLRAILERTRKDLSDLIYDTGAKPQEPNAASPEAGNQGEEKPETR
>CP035758.1|QBD75923.1|1701797_1702610_+|serine-protein-kinase-RIO
MSKRQKYTRSIEEQEELAALEELTLQQDSDPIAAELDPFIADGLITEVLYRVKSGKEATVYCCRAHPRTGVNYLAAKIYSSRNRRNFKNDSIYREGRVVLDSHLRRAIKKKSAVGRQAEFGMWIHHEFETLNVLHKAGSLVPRPYASSSSVIIMEYVGDEQQAAPGLYSAELKPGEAARIFDQLIANIQLWLGYNYVHGDLSSYNILYWQGQIKIIDFPQAVDPRFNGHAYNLLLRDIENVCKYAARYGLERDAQAIAGRMWEKFVRARL
>CP035758.1|QBD75922.1|1700035_1701214_-|pyridoxal-phosphate-dependent-enzyme
MAFQLVCSRCQQIYEPGSLLWRCPCGGLFDLATFPISFPRERINSRPPTLWRYLEALPFDPNYVGWQKVTMGEGYTPLVQLPIQQPGAWFKMDYSMPTLSFKDRGAAVLIAKAAELGVEHVIADSSGNAGTAIAAYAARAGITCDIYVPASASSKKLKQIAAHGASVHAIAGSREDTAAAAIAAVERGGVFYASHVYNPFFYQGTKTYAFEIWEQLGGHMPDSLILPVGNGTLVLGAYYGCQDLLRAGLIERLPRLLAVQAENCAPLAQAFEHNEADAAPVENKGTVAEGIAIAAPARSRQILAALRESHGAIITVSEAEIETARLGLARQGLYVEPTAAVPYAGYLCALNAPEGQNLANTSVAASYLNEMRQAIPQGQVVISLCGAGLKAA
>CP035758.1|QBD75921.1|1699472_1699850_-|hypothetical-protein
MMTPQMNADDGYSYRGYEGAQQQYETPHAPSGQERMYDDEFVDSLAQRLSQRMSQNAAGKVYAQPNKKSSNQRFVLAMISVIMIALMGAIVMASGSGFLGLVGAAVLSFIIFLVNAVFYNSPNHN
>CP035758.1|QBD75920.1|1699206_1699425_-|hypothetical-protein
MVAHQIPWLHCIEPKWVHGKRAIVEPTRLLTTQEVRQRVGAIFAVSRLNCSHKRLHASSLMEVHIRDYSASA
>CP035758.1|QBD75919.1|1696420_1697122_-|PIG-L-family-deacetylase
MTTSILLPPAAQRILVIFAHPDDAESYCGGTMARLAHEECEIMYLAVTRGDKGSNNPSMTPERLSPIRENEQRQAASILGVQSVTFLAGYYDGMLVPDLSLRKDLTLWIRKWRPDVVFTFDPWKRYELHPDHRATGICAFDALAVARDRFTFPDLNAEAPAHNVKQIYFFNTDEPNHWVDISNVIDKKIEARCAHASQVNPANPPDGYLRRWGVETGKACGYAFAEAFHHLGL
>CP035758.1|QBD75918.1|1695876_1696170_+|Dabb-family-protein
MILHVVLLRPKPEVSLAQIQIALDHVKDLQHKVPGILEVDAGANKNESNNKGYTYGFAMRFVDETHLQAYAPHPEHRVVGAELVQLCESIIDFDLPL
>CP035758.1|QBD75917.1|1693951_1695880_+|hypothetical-protein
MVGKEDPLVHVSVRLLGIFQVERKNEQDVWEPIDAPAWGSTYARPLFRRLLCTPGRCLSREQLIRDVLPAGRDDVTTDHYLHKCAYKIRQLFGKEAITTSSVSYRLADQTYIWSDLEAAETLMQKAERLERKQALPLLEEACKLFGRGEALEGETGQWHHAICAAVEREKKSCYLALGHIYEQQGMLWSAEKIYRDLAALYPLDEAALCAQLAFLQRAGMRTEAIAYYEQARAYFVEEGLELSAETQRLLKEISHSLPVQEIFAPQAASIPKNEVVLSWMLAQSPGILEEKASIKPEQKGQNMDQSRRDFLFTLGMVSTGLIATQDLHYESDNSSLPGASEASIGNLAIITHQFRAMQRRGDISIAQGLKTHIETIQGTLEITSNEKLRRELWRLLAQTQLIARLNPHKRSDLARLKTLNEMAIAAARNSGDVFLEAAAVGHLAHLYLREYHDLSKASQFFEDVYQKTHICQALRGWIALVMSSIAARQEDRPKCEVLMAEAMDIAIQIPQTPQNDDPYFTDFSILSISMFGGNNWLALGQARKAYEILSTRNIEELSANRQASAFYDLARTYIALGELEEAQKYAFRSIDTALVTGNNSILPRFITLANAIQEKYSGEPHATAIAEYAQSCMPMKGKVQYV
>CP035758.1|QBD75926.1|1707451_1707754_+|transposase
MQKRVHSREFKLDVVRQVATGQKRPAQACREYGLAESVLSRWRKEYQERGEAAFLPSPAEESTKQEQRIAELEQFCGQLALENQILKKTLQRWESRIATQ
>CP035758.1|QBD75927.1|1707726_1708467_+|IS3-family-transposase
MGVADRHAMITQAHQEHPELSIARLCDLLDVSRSWYYGRDNQVASEEIALRDEIERIILEFAGYGYRRVTRELARRGWRVNHKRVLRIMREESLLCQIKKRFVVVTTDSRHGFPVYPNLLAEKTLSAPDQAWVADFTYIRLRSAFVYLACILDAFSRRCVGWHLSREMNAQMTGRALQQAIGERRPQPGLIHHSDRGVQYASHEYIEQLLAVKAHISMSAMGNPYDNAKAESFFKTLKQEEVYLKE
>CP035758.1|QBD75928.1|1709818_1710244_+|transcriptional-regulator
METKQEIVPPRISIADVHCPVRQALDLITDKWTPLVIYLLRPGPLRYTQLKRQIGGITQKMLTQTLRKLEHEGLATRTVYPTSPPTVEYALTPLGESLSQPIEELFRWAWTRGIEMRTVREQRAQAEEPTSAQEPQVPVSK
>CP035758.1|QBD75929.1|1710735_1711611_-|LLM-class-flavin-dependent-oxidoreductase
MSNQLHFGIHTPQQHISYQRLLEIWLEADREPLIDHMWLFDHFMPLREPTDGPCFEGWTLLAALATRTERVRLGHLVTGNTYRHPAILARQAVTVDHISGGRLNFGIGAAAQEHQGYGLAYPGAAERVKRLDEACQVIRQLWTETTPTFEGHYYQLHEAHSEPKPLQRPFPPIIIAAAGDQMLRVVAKHANVWSAMSPTIEDFREKNARLTQLCEAIGRDPSMLERLAAFRLNPADTDFRQARETAQSWIEAGATHLVLSIVELYQQEEVIPRLLDEIIKPLKQSNEQKSA
>CP035758.1|QBD75930.1|1711744_1712188_-|MarR-family-transcriptional-regulator
MRMKTESFLQMFAYLSRIAKEACGQQLQRYGVHAGQHYLLELLWETPEGLTVGEIAERLAVEAPSITRTVRRMSRQGLVEKHPHPTDARLVIVKLTTKGKALEPVIPQVISHVEEQMLAGLSEVERAFLMRLLKHMLQNLEDIPSAP
>CP035758.1|QBD75931.1|1712537_1712768_+|hypothetical-protein
MTAWPALQNRWHDRLPHLASQVLTLNGSIDILGGAAGAGVGGRIVSTSRSRPWCGQEVRSRLRPFCFSYSAKGVIK
>CP035758.1|QBD75932.1|1712828_1713944_-|epoxide-hydrolase
MITPFTLAIPQADLDDLKARLARVRWANELSGVGTDYGVPLSPIKRLVKYWQEGYDWRIWEAKLNAYPQFTTTIDGQNIYFLHIRSREEGALPLLLTHGWPSSVVDYLDLIGPLTDPRSHGGEAAQAFHLVIPSLPGFGFSGPTHAVGWDRYRVARAWAELMHRLGYERYGLHGNDWGSIVSPEVGRCDPEHVVGVHVTQIFSEASGDPAEMEALSEEEKQQWQAIQWWEKNKGVYNLAQSTVPQTLAHALADSPVGQLAWNYQIYGDDESDDYILTNVMIYWLTNTAASSARFYYENAHAKHVPTEPTTIPLGLSKFANDYPAIRPFAERDHKNIVFWRIYDRGNHFATQTAPNLLINDIRAFFAQVRQG
>CP035758.1|QBD75933.1|1714711_1715815_-|HAMP-domain-containing-protein
MKRRPMRRWFARVWLLYAVLMFIAVGMIIITFVAAGSGNTGGQPLPLVPRLWLVAALILVILLVMQALLVAMTARFLHRSILMPLDAIGKASRQIGQGNLSFLLPSSSTMEMAEVITAFNAMGKALREALARQEKLEEERRFFISAVVHDLRTPLFSLRGYLEGIEAGVADTPEMIAHYIRVCCEKANDLEHLITDLFTYTRLELLELQPQREHVDMDELLQKVVEDMRPIAESSALTLTARCEGSPGLDTMVVDRRLITRALENLLDNAIRYTPRYGSIAFNWTWSEEHLLLTVADTGPGIAPQDLPHVFKPLHRGEASRNRQTGGAGLGLSIAQQIFQAHGGELSVTNRASGGAMFLGVLPISRT
>CP035758.1|QBD75934.1|1715811_1716501_-|response-regulator-transcription-factor
MNQPTTILIVDDDSAIAYLLRDFFKAEGFHVLVASDANKALNIVQETPVDCMILDVMMPGRSGFDLCRQLRETSDLPILFLSAYDSDRERLRGFGLQGDDYIAKSASPSEIVARVKAVLRRCQREKPSSRVYNFGRLMIDPVAHEVLRDGCPVPFTTREFALLCLLAEHPRQVFTREQLFERFWGEIGDRQTVTVHIRRIREKIEENPADPRYIITVRGVGYRFEGVSQ
>CP035758.1|QBD75935.1|1716722_1717001_+|hypothetical-protein
MNLLLHLILDFVPMVILFAVAASIYHRKGMRGKKWYRLMGVSIAVLLLVALCSFSVGGTLFSVLLPVVFGLLAVGSAIWWRPPTVKGEVTDR

Crispr_ID: CP035758_11

• CRISPR_ID: CP035758_11
• CRISPR_location: 1708806-1709643
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 11 spacers

Consensus repeat of CP035758_11

Consensus_repeat	Method
GCAGGGAGGAAGGACCGTTAGAGG	CRISPRCasFinder
TCTTACAGTAACCTCTAACGGTCCTTCCTCCCTGCAAC	PILER-CR

spacers of CP035758_11

>11.1|1708830|51|CP035758|CRISPRCasFinder
TTACTGTAAGTCCTTATCCACATGCGATTTGAGATGCTCGCATGTCATGTA
>11.2|1708905|48|CP035758|CRISPRCasFinder
ATACTGTAAGGGCTATTAGGGTAGAGATGGAATGCTGTGAAAAAAGGT
>11.3|1708977|48|CP035758|CRISPRCasFinder
ATACTGTAAGTGCTTGGCTGCAGCACCCGTCCGCAAAGAAGGCAAGTA
>11.4|1709049|51|CP035758|CRISPRCasFinder
ATACTGTAAGATCTATGAGCTCCTTGCCTATCTGCTGGAGCTGGTGATGTA
>11.5|1709124|51|CP035758|CRISPRCasFinder
ATACTGTAAGAGTGTGTTGGCAATCGTTTGCCAGGTGCAGCCCGCCCGGTA
>11.6|1709199|51|CP035758|CRISPRCasFinder
AGACTGTAAGGAAACCGAAGAGAAAGCCTTGGCTCGGGCGATGCTCTTGTA
>11.7|1709274|52|CP035758|CRISPRCasFinder
AGACTGTAAGATAATGTCTAGCATGTTTTGCTGAATATCAGGCAATTCAGTA
>11.8|1709350|48|CP035758|CRISPRCasFinder
AGACTGTAAGTTCTCGCACCAGGACCTACGAGAGAGCCGTATTGTGTA
>11.9|1709422|48|CP035758|CRISPRCasFinder
AGACTGTAAGTCGTCTATCAAAACCAGTACAATCTATGGTCTCTGGTT
>11.10|1709494|51|CP035758|CRISPRCasFinder
TTACTGTAAGAACAAGAAGCGCTTCCTGGATCAAGGGATCAGATGCCAGTT
>11.11|1709569|51|CP035758|CRISPRCasFinder
TTACTGTAAGAGCGCCTCTTTGGCGACGGCGTAGAATGACCTCCACAGGTG
>11.12|1709433|34|CP035758|PILER-CR
CGTCTATCAAAACCAGTACAATCTATGGTCTCTG
>11.13|1709505|37|CP035758|PILER-CR
ACAAGAAGCGCTTCCTGGATCAAGGGATCAGATGCCA

CRISPR arrays and Neighbor proteins around CP035758_11

CRISPR arrays

The CRISPR arrays of CP035758_11

>merge|CP035758|11|1708806-1709643|CRISPRCasFinder,PILER-CR
GCAGGGAGGAAGAGGCGTTCGAGATTACTGTAAGTCCTTATCCACATGCGATTTGAGATGCTCGCATGTCATGTAGCAGGGAGGAAGAGCCGTAGGAGGATACTGTAAGGGCTATTAGGGTAGAGATGGAATGCTGTGAAAAAAGGTAGCAGGAAAAAGGACCGTTCGAGGATACTGTAAGTGCTTGGCTGCAGCACCCGTCCGCAAAGAAGGCAAGTAGCAGGGAGTGCAAGCCGTTCGAGGATACTGTAAGATCTATGAGCTCCTTGCCTATCTGCTGGAGCTGGTGATGTAGCAGGGAGGAAGAGCCGTAAGAGGATACTGTAAGAGTGTGTTGGCAATCGTTTGCCAGGTGCAGCCCGCCCGGTAGCAGGGAGGAAGGACCGTTCGAGGAGACTGTAAGGAAACCGAAGAGAAAGCCTTGGCTCGGGCGATGCTCTTGTAGCCGAGAGGAAGAACCGTTAGAGGAGACTGTAAGATAATGTCTAGCATGTTTTGCTGAATATCAGGCAATTCAGTAGCCGAGAGGAAGAACCGTTAGAGGAGACTGTAAGTTCTCGCACCAGGACCTACGAGAGAGCCGTATTGTGTAGCAGGGAGGAAGGACCGTTAGAGGAGACTGTAAGTCGTCTATCAAAACCAGTACAATCTATGGTCTCTGGTTGCAGAGAGGAAGGACCGTTAGAGGTTACTGTAAGAACAAGAAGCGCTTCCTGGATCAAGGGATCAGATGCCAGTTGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAGAGCGCCTCTTTGGCGACGGCGTAGAATGACCTCCACAGGTGGGAGGGAGGACGAGCCGTAAGAGG

>CP035758|11|10|1708806-1709643|CRISPRCasFinder
GCAGGGAGGAAGAGGCGTTCGAGA	TTACTGTAAGTCCTTATCCACATGCGATTTGAGATGCTCGCATGTCATGTA
GCAGGGAGGAAGAGCCGTAGGAGG	ATACTGTAAGGGCTATTAGGGTAGAGATGGAATGCTGTGAAAAAAGGT
AGCAGGAAAAAGGACCGTTCGAGG	ATACTGTAAGTGCTTGGCTGCAGCACCCGTCCGCAAAGAAGGCAAGTA
GCAGGGAGTGCAAGCCGTTCGAGG	ATACTGTAAGATCTATGAGCTCCTTGCCTATCTGCTGGAGCTGGTGATGTA
GCAGGGAGGAAGAGCCGTAAGAGG	ATACTGTAAGAGTGTGTTGGCAATCGTTTGCCAGGTGCAGCCCGCCCGGTA
GCAGGGAGGAAGGACCGTTCGAGG	AGACTGTAAGGAAACCGAAGAGAAAGCCTTGGCTCGGGCGATGCTCTTGTA
GCCGAGAGGAAGAACCGTTAGAGG	AGACTGTAAGATAATGTCTAGCATGTTTTGCTGAATATCAGGCAATTCAGTA
GCCGAGAGGAAGAACCGTTAGAGG	AGACTGTAAGTTCTCGCACCAGGACCTACGAGAGAGCCGTATTGTGTA
GCAGGGAGGAAGGACCGTTAGAGG	AGACTGTAAGTCGTCTATCAAAACCAGTACAATCTATGGTCTCTGGTT
GCAGAGAGGAAGGACCGTTAGAGG	TTACTGTAAGAACAAGAAGCGCTTCCTGGATCAAGGGATCAGATGCCAGTT
GCAGGGAGGAAGGACCGTTAGAGG	TTACTGTAAGAGCGCCTCTTTGGCGACGGCGTAGAATGACCTCCACAGGTG
GGAGGGAGGACGAGCCGTAAGAGG

>CP035758|11|7|1709395-1709579|PILER-CR
GTAGCAGGGAGGAAGGACCGTTAGAGGAGACTGTAAGT	CGTCTATCAAAACCAGTACAATCTATGGTCTCTG
GTTGCAGAGAGGAAGGACCGTTAGAGGTTACTGTAAGA	ACAAGAAGCGCTTCCTGGATCAAGGGATCAGATGCCA
GTTGCAGGGAGGAAGGACCGTTAGAGGTTACTGTAAGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD75937.1|1718075_1718735_-|hypothetical-protein	unknown	unknown	gnl|CDD|366504
CP035758.1|QBD75931.1|1712537_1712768_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75933.1|1714711_1715815_-|HAMP-domain-containing-protein	unknown	unknown	gnl|CDD|274368
CP035758.1|QBD75928.1|1709818_1710244_+|transcriptional-regulator	unknown	unknown	gnl|CDD|224647
CP035758.1|QBD75925.1|1704838_1705900_+|hypothetical-protein	unknown	unknown	gnl|CDD|224513
CP035758.1|QBD75927.1|1707726_1708467_+|IS3-family-transposase	unknown	unknown	gnl|CDD|222853
CP035758.1|QBD75930.1|1711744_1712188_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
CP035758.1|QBD75924.1|1704333_1704558_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75932.1|1712828_1713944_-|epoxide-hydrolase	unknown	unknown	gnl|CDD|377658
CP035758.1|QBD75923.1|1701797_1702610_+|serine-protein-kinase-RIO	unknown	unknown	gnl|CDD|270696
CP035758.1|QBD75922.1|1700035_1701214_-|pyridoxal-phosphate-dependent-enzyme	unknown	unknown	gnl|CDD|107206
CP035758.1|QBD75920.1|1699206_1699425_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD83399.1|1703323_1704070_+|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224609
CP035758.1|QBD75926.1|1707451_1707754_+|transposase	unknown	unknown	gnl|CDD|225511
CP035758.1|QBD75935.1|1716722_1717001_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75934.1|1715811_1716501_-|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|223816
CP035758.1|QBD75929.1|1710735_1711611_-|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274648
CP035758.1|QBD75921.1|1699472_1699850_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD75919.1|1696420_1697122_-|PIG-L-family-deacetylase	unknown	unknown	gnl|CDD|376836
CP035758.1|QBD75936.1|1717325_1717709_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD75937.1|1718075_1718735_-|hypothetical-protein	gnl|CDD|366504	pfam01184, Grp1_Fun34_YaaH, GPR1/FUN34/yaaH family. The Ady2 protein is required for acetate in Saccharomyces cerevisiae, and is probably an acetate transporter. A homolog in Yarrowia lipolytica (GPR1) has a role in acetic acid sensitivity.	3.23351e-30
CP035758.1|QBD75933.1|1714711_1715815_-|HAMP-domain-containing-protein	gnl|CDD|274368	TIGR02966, Phosphate_regulon_sensor_protein_PhoR, phosphate regulon sensor kinase PhoR. Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems].	6.63895e-54
CP035758.1|QBD75928.1|1709818_1710244_+|transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	1.09886e-37
CP035758.1|QBD75925.1|1704838_1705900_+|hypothetical-protein	gnl|CDD|224513	COG1597, LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only].	4.41039e-34
CP035758.1|QBD75927.1|1707726_1708467_+|IS3-family-transposase	gnl|CDD|222853	PHA02517, PHA02517, putative transposase OrfB; Reviewed.	1.37614e-43
CP035758.1|QBD75930.1|1711744_1712188_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	5.74621e-22
CP035758.1|QBD75932.1|1712828_1713944_-|epoxide-hydrolase	gnl|CDD|377658	pfam06441, EHN, Epoxide hydrolase N-terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.	3.0733e-53
CP035758.1|QBD75923.1|1701797_1702610_+|serine-protein-kinase-RIO	gnl|CDD|270696	cd05145, RIO1_like, Catalytic domain of the atypical protein serine kinases, RIO1 and RIO3 kinases and similar proteins. RIO1 is present in archaea, bacteria and eukaryotes. In addition, RIO3 is present in multicellular eukaryotes. Both RIO1 and RIO3 are associated with precursors of 40S ribosomal subunits, just like RIO2. RIO1 is essential for survival and is required for 18S rRNA processing, proper cell cycle progression and chromosome maintenance. Although depletion of either RIO1 and RIO2 results in similar effects, the two kinases are not fully interchangeable. The specific function of RIO3 is unknown. RIO kinases are atypical protein serine kinases containing a kinase catalytic signature, but otherwise show very little sequence similarity to typical PKs. Serine kinases catalyze the transfer of the gamma-phosphoryl group from ATP to serine residues in protein substrates. The RIO catalytic domain is truncated compared to the catalytic domains of typical PKs, with deletions of the loops responsible for substrate binding. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).	2.21253e-49
CP035758.1|QBD75922.1|1700035_1701214_-|pyridoxal-phosphate-dependent-enzyme	gnl|CDD|107206	cd01563, Thr-synth_1, Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.	1.95796e-115
CP035758.1|QBD83399.1|1703323_1704070_+|PadR-family-transcriptional-regulator	gnl|CDD|224609	COG1695, COG1695, Predicted transcriptional regulators [Transcription].	8.94427e-27
CP035758.1|QBD75926.1|1707451_1707754_+|transposase	gnl|CDD|225511	COG2963, COG2963, Transposase and inactivated derivatives [DNA replication, recombination, and repair].	1.15954e-07
CP035758.1|QBD75934.1|1715811_1716501_-|response-regulator-transcription-factor	gnl|CDD|223816	COG0745, OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription].	2.14222e-82
CP035758.1|QBD75929.1|1710735_1711611_-|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274648	TIGR03560, F420_Rv1855c, probable F420-dependent oxidoreductase, Rv1855c family. Coenzyme F420 has a limited phylogenetic distribution, including methanogenic archaea, Mycobacterium tuberculosis and related species, Colwellia psychrerythraea 34H, Rhodopseudomonas palustris HaA2, and others. Partial phylogenetic profiling identifies protein subfamilies, within the larger family called luciferase-like monooxygenanases (pfam00296), that appear only in F420-positive genomes and are likely to be F420-dependent. This model describes one such subfamily, exemplified by Rv1855c from Mycobacterium tuberculosis. [Unknown function, Enzymes of unknown specificity].	2.10496e-79
CP035758.1|QBD75919.1|1696420_1697122_-|PIG-L-family-deacetylase	gnl|CDD|376836	pfam02585, PIG-L, GlcNAc-PI de-N-acetylase. Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyzes the second step in GPI biosynthesis.	1.04872e-37

Protein sequences

>CP035758.1|QBD75927.1|1707726_1708467_+|IS3-family-transposase
MGVADRHAMITQAHQEHPELSIARLCDLLDVSRSWYYGRDNQVASEEIALRDEIERIILEFAGYGYRRVTRELARRGWRVNHKRVLRIMREESLLCQIKKRFVVVTTDSRHGFPVYPNLLAEKTLSAPDQAWVADFTYIRLRSAFVYLACILDAFSRRCVGWHLSREMNAQMTGRALQQAIGERRPQPGLIHHSDRGVQYASHEYIEQLLAVKAHISMSAMGNPYDNAKAESFFKTLKQEEVYLKE
>CP035758.1|QBD75926.1|1707451_1707754_+|transposase
MQKRVHSREFKLDVVRQVATGQKRPAQACREYGLAESVLSRWRKEYQERGEAAFLPSPAEESTKQEQRIAELEQFCGQLALENQILKKTLQRWESRIATQ
>CP035758.1|QBD75925.1|1704838_1705900_+|hypothetical-protein
MKKALLIHSPGSGKSALLSQTIEGLQAAGIEVVEHIPISALGDGAAGRWAEQELDFVVAAGGDGLIGGLLSHVIGCKLPLGIIPLGTANDVARSVGIPLEIQAAAEAMASSVVREIDIGAAHPGLDEAEPAQGDEKSRKRASLLFAHALTVGINAQFARQATSSSVREQYGALTYPFALKEAVRTYAPIDVELRFHGLVEWSADGSCVTMTEEELSLSCRAAQATVVNAPIFWGPLQATVPGVSLRDRVLDIVVVEDASLQDLMLRLARFFNRQEQRPALPADWHARYPELLAAQRTDIPGIHHVQARGVTIATRGKCQDVTLDGEIACQTPVYARVAAERLRLLVPDPQAVV
>CP035758.1|QBD75924.1|1704333_1704558_+|hypothetical-protein
MQSQPVSRLLSRTELSNVSPSVTLQSQDQPALLAEQQASHSECLLEDSPDQQLESTGRAFERLFTRLFCRGLLF
>CP035758.1|QBD83399.1|1703323_1704070_+|PadR-family-transcriptional-regulator
MSRFFAMRGKRGFGPQGPFGPQDQGDLFGPGGPFGPEVPHGPRGPFGPRGPHGHHQRGQGPFEGRHFFGRGDVKYALLALMQERPMHGYEMMKALEERSNGLYVPSAGTIYPTLQMLEDRGLISVQEVEGKKVYSITDDGRKALADRQQEEDQFAHPFWGRFGPHAHRWDSPEIHALRSEAAGVAQLFVAAARQVFFDESKAQRLRAILERTRKDLSDLIYDTGAKPQEPNAASPEAGNQGEEKPETR
>CP035758.1|QBD75923.1|1701797_1702610_+|serine-protein-kinase-RIO
MSKRQKYTRSIEEQEELAALEELTLQQDSDPIAAELDPFIADGLITEVLYRVKSGKEATVYCCRAHPRTGVNYLAAKIYSSRNRRNFKNDSIYREGRVVLDSHLRRAIKKKSAVGRQAEFGMWIHHEFETLNVLHKAGSLVPRPYASSSSVIIMEYVGDEQQAAPGLYSAELKPGEAARIFDQLIANIQLWLGYNYVHGDLSSYNILYWQGQIKIIDFPQAVDPRFNGHAYNLLLRDIENVCKYAARYGLERDAQAIAGRMWEKFVRARL
>CP035758.1|QBD75922.1|1700035_1701214_-|pyridoxal-phosphate-dependent-enzyme
MAFQLVCSRCQQIYEPGSLLWRCPCGGLFDLATFPISFPRERINSRPPTLWRYLEALPFDPNYVGWQKVTMGEGYTPLVQLPIQQPGAWFKMDYSMPTLSFKDRGAAVLIAKAAELGVEHVIADSSGNAGTAIAAYAARAGITCDIYVPASASSKKLKQIAAHGASVHAIAGSREDTAAAAIAAVERGGVFYASHVYNPFFYQGTKTYAFEIWEQLGGHMPDSLILPVGNGTLVLGAYYGCQDLLRAGLIERLPRLLAVQAENCAPLAQAFEHNEADAAPVENKGTVAEGIAIAAPARSRQILAALRESHGAIITVSEAEIETARLGLARQGLYVEPTAAVPYAGYLCALNAPEGQNLANTSVAASYLNEMRQAIPQGQVVISLCGAGLKAA
>CP035758.1|QBD75921.1|1699472_1699850_-|hypothetical-protein
MMTPQMNADDGYSYRGYEGAQQQYETPHAPSGQERMYDDEFVDSLAQRLSQRMSQNAAGKVYAQPNKKSSNQRFVLAMISVIMIALMGAIVMASGSGFLGLVGAAVLSFIIFLVNAVFYNSPNHN
>CP035758.1|QBD75920.1|1699206_1699425_-|hypothetical-protein
MVAHQIPWLHCIEPKWVHGKRAIVEPTRLLTTQEVRQRVGAIFAVSRLNCSHKRLHASSLMEVHIRDYSASA
>CP035758.1|QBD75919.1|1696420_1697122_-|PIG-L-family-deacetylase
MTTSILLPPAAQRILVIFAHPDDAESYCGGTMARLAHEECEIMYLAVTRGDKGSNNPSMTPERLSPIRENEQRQAASILGVQSVTFLAGYYDGMLVPDLSLRKDLTLWIRKWRPDVVFTFDPWKRYELHPDHRATGICAFDALAVARDRFTFPDLNAEAPAHNVKQIYFFNTDEPNHWVDISNVIDKKIEARCAHASQVNPANPPDGYLRRWGVETGKACGYAFAEAFHHLGL
>CP035758.1|QBD75928.1|1709818_1710244_+|transcriptional-regulator
METKQEIVPPRISIADVHCPVRQALDLITDKWTPLVIYLLRPGPLRYTQLKRQIGGITQKMLTQTLRKLEHEGLATRTVYPTSPPTVEYALTPLGESLSQPIEELFRWAWTRGIEMRTVREQRAQAEEPTSAQEPQVPVSK
>CP035758.1|QBD75929.1|1710735_1711611_-|LLM-class-flavin-dependent-oxidoreductase
MSNQLHFGIHTPQQHISYQRLLEIWLEADREPLIDHMWLFDHFMPLREPTDGPCFEGWTLLAALATRTERVRLGHLVTGNTYRHPAILARQAVTVDHISGGRLNFGIGAAAQEHQGYGLAYPGAAERVKRLDEACQVIRQLWTETTPTFEGHYYQLHEAHSEPKPLQRPFPPIIIAAAGDQMLRVVAKHANVWSAMSPTIEDFREKNARLTQLCEAIGRDPSMLERLAAFRLNPADTDFRQARETAQSWIEAGATHLVLSIVELYQQEEVIPRLLDEIIKPLKQSNEQKSA
>CP035758.1|QBD75930.1|1711744_1712188_-|MarR-family-transcriptional-regulator
MRMKTESFLQMFAYLSRIAKEACGQQLQRYGVHAGQHYLLELLWETPEGLTVGEIAERLAVEAPSITRTVRRMSRQGLVEKHPHPTDARLVIVKLTTKGKALEPVIPQVISHVEEQMLAGLSEVERAFLMRLLKHMLQNLEDIPSAP
>CP035758.1|QBD75931.1|1712537_1712768_+|hypothetical-protein
MTAWPALQNRWHDRLPHLASQVLTLNGSIDILGGAAGAGVGGRIVSTSRSRPWCGQEVRSRLRPFCFSYSAKGVIK
>CP035758.1|QBD75932.1|1712828_1713944_-|epoxide-hydrolase
MITPFTLAIPQADLDDLKARLARVRWANELSGVGTDYGVPLSPIKRLVKYWQEGYDWRIWEAKLNAYPQFTTTIDGQNIYFLHIRSREEGALPLLLTHGWPSSVVDYLDLIGPLTDPRSHGGEAAQAFHLVIPSLPGFGFSGPTHAVGWDRYRVARAWAELMHRLGYERYGLHGNDWGSIVSPEVGRCDPEHVVGVHVTQIFSEASGDPAEMEALSEEEKQQWQAIQWWEKNKGVYNLAQSTVPQTLAHALADSPVGQLAWNYQIYGDDESDDYILTNVMIYWLTNTAASSARFYYENAHAKHVPTEPTTIPLGLSKFANDYPAIRPFAERDHKNIVFWRIYDRGNHFATQTAPNLLINDIRAFFAQVRQG
>CP035758.1|QBD75933.1|1714711_1715815_-|HAMP-domain-containing-protein
MKRRPMRRWFARVWLLYAVLMFIAVGMIIITFVAAGSGNTGGQPLPLVPRLWLVAALILVILLVMQALLVAMTARFLHRSILMPLDAIGKASRQIGQGNLSFLLPSSSTMEMAEVITAFNAMGKALREALARQEKLEEERRFFISAVVHDLRTPLFSLRGYLEGIEAGVADTPEMIAHYIRVCCEKANDLEHLITDLFTYTRLELLELQPQREHVDMDELLQKVVEDMRPIAESSALTLTARCEGSPGLDTMVVDRRLITRALENLLDNAIRYTPRYGSIAFNWTWSEEHLLLTVADTGPGIAPQDLPHVFKPLHRGEASRNRQTGGAGLGLSIAQQIFQAHGGELSVTNRASGGAMFLGVLPISRT
>CP035758.1|QBD75934.1|1715811_1716501_-|response-regulator-transcription-factor
MNQPTTILIVDDDSAIAYLLRDFFKAEGFHVLVASDANKALNIVQETPVDCMILDVMMPGRSGFDLCRQLRETSDLPILFLSAYDSDRERLRGFGLQGDDYIAKSASPSEIVARVKAVLRRCQREKPSSRVYNFGRLMIDPVAHEVLRDGCPVPFTTREFALLCLLAEHPRQVFTREQLFERFWGEIGDRQTVTVHIRRIREKIEENPADPRYIITVRGVGYRFEGVSQ
>CP035758.1|QBD75935.1|1716722_1717001_+|hypothetical-protein
MNLLLHLILDFVPMVILFAVAASIYHRKGMRGKKWYRLMGVSIAVLLLVALCSFSVGGTLFSVLLPVVFGLLAVGSAIWWRPPTVKGEVTDR
>CP035758.1|QBD75936.1|1717325_1717709_+|hypothetical-protein
MDENTSTAVVVAADYGKAPFLAHAYIIDKASERIIQTFDFHNDIVDAGFDGDTLYLFNDKLGYFVDTKSGAQLHNILETDNYRGLFESNGNRFVQSDITVSAITSTWHLIVRHHFHMSSVAYGCYLP
>CP035758.1|QBD75937.1|1718075_1718735_-|hypothetical-protein
MAQYGTTPRDQEHVDVIREDVASPAPLGLSILAFATALIGCFYAGFIIPYAVPAIRVALGPVLLISGIVLILAGMWEFRKNYTISATIFTTYGGFLAAVGLVFMPTLGIISALGGVRLLSLTLGLIFLCWTIVNAILFLGTLRTNVSLMVSMLLLTVAFLLLTIGQLAFDNRVLLAIGGWIAIVCALFTWLAAAASILSTTGVHGGFRLPLGQKIAAVE

Crispr_ID: CP035758_12

• CRISPR_ID: CP035758_12
• CRISPR_location: 2212214-2212311
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP035758_12

Consensus_repeat	Method
CACAAAAAAAGATGGGCACCATCAGG	CRISPRCasFinder

spacers of CP035758_12

>12.1|2212240|46|CP035758|CRISPRCasFinder
AATGATGACGGAAAAGCTCTCTCTGGGATTTCTAACGGGTCAGATT

CRISPR arrays and Neighbor proteins around CP035758_12

CRISPR arrays

The CRISPR arrays of CP035758_12

>merge|CP035758|12|2212214-2212311|CRISPRCasFinder
CACAAAAAAAGATGGGCACCATCAGGAATGATGACGGAAAAGCTCTCTCTGGGATTTCTAACGGGTCAGATTACACAAAAAAAGATGGCACCATCAGG

>CP035758|12|11|2212214-2212311|CRISPRCasFinder
CACAAAAAAAGATGGGCACCATCAGG	AATGATGACGGAAAAGCTCTCTCTGGGATTTCTAACGGGTCAGATT
ACACAAAAAAAGATGGCACCATCAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD76352.1|2209968_2211015_-|hydroxyacid-dehydrogenase	unknown	unknown	gnl|CDD|240663
CP035758.1|QBD76363.1|2221167_2222025_-|hypothetical-protein	unknown	unknown	gnl|CDD|273359
CP035758.1|QBD76346.1|2204039_2204666_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188483
CP035758.1|QBD76349.1|2206297_2207155_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
CP035758.1|QBD76357.1|2217202_2217457_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76358.1|2217453_2217891_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76359.1|2217910_2218807_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
CP035758.1|QBD76361.1|2219468_2220527_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76356.1|2216473_2217184_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76350.1|2207292_2207964_+|hypothetical-protein	unknown	unknown	gnl|CDD|224996
CP035758.1|QBD76360.1|2218877_2219093_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76347.1|2204742_2205087_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|369571
CP035758.1|QBD76344.1|2201314_2202034_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293807
CP035758.1|QBD76348.1|2205380_2205845_+|hypothetical-protein	unknown	unknown	gnl|CDD|223526
CP035758.1|QBD76354.1|2213734_2214889_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|275041
CP035758.1|QBD76355.1|2216222_2216429_-|hypothetical-protein	unknown	unknown	gnl|CDD|226728
CP035758.1|QBD76345.1|2202690_2203941_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
CP035758.1|QBD76362.1|2220634_2221075_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76351.1|2208218_2209838_-|hypothetical-protein	unknown	unknown	gnl|CDD|223104
CP035758.1|QBD76353.1|2211375_2212155_+|dienelactone-hydrolase-family-protein	unknown	unknown	gnl|CDD|223489

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD76352.1|2209968_2211015_-|hydroxyacid-dehydrogenase	gnl|CDD|240663	cd12187, LDH_like_1, D-Lactate and related Dehydrogenase like proteins, NAD-binding and catalytic domains. D-Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate, and is a member of the 2-hydroxyacid dehydrogenase family. LDH is homologous to D-2-Hydroxyisocaproic acid dehydrogenase(D-HicDH) and shares the 2 domain structure of formate dehydrogenase. D-2-hydroxyisocaproate dehydrogenase-like (HicDH) proteins are NAD-dependent members of the hydroxycarboxylate dehydrogenase family, and share the Rossmann fold typical of many NAD binding proteins. HicDH from Lactobacillus casei forms a monomer and catalyzes the reaction R-CO-COO(-) + NADH + H+ to R-COH-COO(-) + NAD+. D-HicDH, like the structurally distinct L-HicDH, exhibits low side-chain R specificity, accepting a wide range of 2-oxocarboxylic acid side chains. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain.	2.07432e-139
CP035758.1|QBD76363.1|2221167_2222025_-|hypothetical-protein	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.63914e-19
CP035758.1|QBD76346.1|2204039_2204666_+|TetR-family-transcriptional-regulator	gnl|CDD|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	7.64794e-19
CP035758.1|QBD76349.1|2206297_2207155_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.39766e-13
CP035758.1|QBD76359.1|2217910_2218807_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.25926e-13
CP035758.1|QBD76350.1|2207292_2207964_+|hypothetical-protein	gnl|CDD|224996	COG2085, COG2085, Predicted dinucleotide-binding enzymes [General function prediction only].	8.52299e-23
CP035758.1|QBD76347.1|2204742_2205087_-|cupin-domain-containing-protein	gnl|CDD|369571	pfam07883, Cupin_2, Cupin domain. This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).	4.11447e-16
CP035758.1|QBD76344.1|2201314_2202034_-|MBL-fold-metallo-hydrolase	gnl|CDD|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.09348e-65
CP035758.1|QBD76348.1|2205380_2205845_+|hypothetical-protein	gnl|CDD|223526	COG0449, GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane].	0.00560885
CP035758.1|QBD76354.1|2213734_2214889_-|methyltransferase-domain-containing-protein	gnl|CDD|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	4.47995e-61
CP035758.1|QBD76355.1|2216222_2216429_-|hypothetical-protein	gnl|CDD|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	1.65402e-05
CP035758.1|QBD76345.1|2202690_2203941_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	9.90957e-90
CP035758.1|QBD76351.1|2208218_2209838_-|hypothetical-protein	gnl|CDD|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	2.31723e-44
CP035758.1|QBD76353.1|2211375_2212155_+|dienelactone-hydrolase-family-protein	gnl|CDD|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	2.23605e-44

Protein sequences

>CP035758.1|QBD76353.1|2211375_2212155_+|dienelactone-hydrolase-family-protein
MMLDKASEHEIATEHVNVPVDEESATAPLGMYMAQPVEPGSYPGVIVGFELFGLTGYVRKVVERIARLGYVVVAPDFYHRSAPGIELAADAEGRTRGFALLHQLTRQQALNDVRAAMSYLRNVQGCAKLGIVGLSVGGHIAYLAATQLDLKATVAFYAGWLPGTEIPLSRPEPTLALTPGIASHDGYLLFLVGENDALIPREQRAVIATALNEAKVRHELVEYSGAPHGFFCDERESYEPVAAADGWRRLQSLFAAELV
>CP035758.1|QBD76352.1|2209968_2211015_-|hydroxyacid-dehydrogenase
MENNTQQNSSLVHALATTVNEEDGRYLNEHLGHVLSLRLTPALPQDMPASELSEVEILIPFVNTRIGREEIDAMPRLQLIATRSTGYDHIDTGYAAERGIAVANVPGYGETAVAEYTFALLLALSRKLRRILTRQNGTSIEELRGFDLHGKTLGVVGTGAIGLNVIRIANGFGMQVLAYDVRKKHFMAELLNFRYLPLPELLTDSDIITLHVPSLASTYHLLNRQNLPSLKPGALLINTARGTLVETEALVEALDNGILSGAGLDTLEGEEFLQAGDISAPDLQTDEQRKLLELYHSLQQRENVIITPHIAFASKEALKRILDTTIENVLAFLEGRSSNLVTPKAMVH
>CP035758.1|QBD76351.1|2208218_2209838_-|hypothetical-protein
MEKPFIMSEVSTESFITLLAMIGIVIIIAALLSGLIERTGFPQVAVFLVLGAVLGPFGLGVLNIGLDSPILRIVAPLSLVMVLFTDAISLNLNEIRRAGVLTLLVLGPGTLLSAALIALAAWGLLGLPLAAAVLLGAALSSTDPVLLRGLLRRRDIPATARTALSLESSLNDVVLLPIVIVTMTFLQQGHSPSGSDWGHLILDLFVLGPGAGILVGVCAVATLDVVRRHLTVRRDYESLFSLGIAFTAYAAAEAVHGSGFLAAFAAGLTISSLDVELCDCFTEYGETTTEMALLLTFVIFGSSLIWSGIEHITPILVLFAIIALLVRPVAFTVSLSRIRLSRYEKILTAWFGPRGLSSLLLIMLPVFANIPGSTQLFSICSLVVLFSVVVHGGSPFILSRRPPRRKRQIPQGTSPLEEEEATPAVATAPPPAVVPNEPTGTYHGSLITLQPPNRNRNPKKEEAPQFQTADPIRITLDELRQLWHTKARIILLDARKERSYSKSDKQAKGSLRVVPDETIVEQIRELDIPKETWIVAYCT
>CP035758.1|QBD76350.1|2207292_2207964_+|hypothetical-protein
MLELKICNQGEDTMTEEKQIIAVLGASNIGGTLGRKWHAAGHTVAFGVSDPQGKNAQAIRADLGNAVSIGTTTEVLRTNPNVVLIATPPTAVSEIVSANAAHLNGRTIIDATNRIGEAVLYDQQLFQRYVPKAHIFRAFNTLGWENFVNPLFDGVQADLFFCGAPARRAAVDALIRGIGLNPIYLGDVDQAELLDGITKLWFTLALKQGKGRHLAFKVLTDQA
>CP035758.1|QBD76349.1|2206297_2207155_+|GNAT-family-N-acetyltransferase
MSLVQGKMKEGLGEADHAHIRELLRVCHQFDGLEFPLSLEGMLYAPNNVLLCYQHETLLGMVYVMSEGDVELLGLVHPEYRRQGVGRSLLEAAKTFCRRKQVSHLSLVCFEAMPAGEAFCRAVGGQYEKSEFHMVLDMQVLRPLEPLDVALSLRQADAADARTLAHFLAQEFEEAEEEMYSWIEADLKKPGRRAFLVVLGEEPIGTLRMFEDDSSVEITAFGILPPYRRHGYGRRILLQAVHMLLTEGWQHIALDVETENRKALALYLSCGFRQTREDRFYRLDL
>CP035758.1|QBD76348.1|2205380_2205845_+|hypothetical-protein
MPNTLATELENSGRTVEVIAAYVQHYVNERYQQAWQEMLPELEQTYATKGEPAYGLYCIRFFQPLKEELEQVGLQAEQNLPGNFPSSIEEWGPRDYRERRFWTVLRESNGEKLGTLVTRIFHDHTKLRLPQAPAVLPLSQTDDEAIKQFVMQID
>CP035758.1|QBD76347.1|2204742_2205087_-|cupin-domain-containing-protein
MDYTLLQRKELPRDGNTYEFEGKRYGETDISFIWVDMPPGESVRLHRHAYKEIFLVQEGSATYTVGTETLEIQAGQIVIVPAGIPHKFRNSGTVPLKQVDLHLSKQIVTEWLED
>CP035758.1|QBD76346.1|2204039_2204666_+|TetR-family-transcriptional-regulator
MSDTFFTRDDSAQRISLRERKKRLVQTTIEETALRLFQQQGYEQTSIQDIAEAVMMSTRTFFRYFASKEEVLFGPIHTSLYESMRVLQQVAPTATPHAALRTTFMHMADLYQQQRASFLIRYQVAAQTPSIASIYLYTMMEKEPEICDVLCSRLDGSMDYHEMRLLVGMYMAVFRIAVEIWLKQKAQGDLVSLLREYLDLCSSLSHNI
>CP035758.1|QBD76345.1|2202690_2203941_-|cytochrome-P450
MNTPEQATFSLFSGELAENPFTLLAQLRSLGAIVPVPFPLGGTERQVWVVTRMEEAVRILKDHVHFTVDRRIISDTSLFGQNAEEHTNLSAPPSFFSAGTSMLTVDMPDHRRLRTLISKAFTPRYIEGLRPRVQQIADELLNQVQEQGQMDLVEEYAFPLPINVISEMLGVPQADRARVRVWSAALATGLGLGKREPGIIAHIQAFADYAAHLVADKRQHPADDLVSQLTAIEEQGDRLSEAELLSMITLLIFAGHETTSNLIATGTLMLLDHPAQFEKLKADLSLVPLAIEELLRFNGPAMIAGPRYATEEIEVAGQRIQQGDIVIPILRSANRDESQFTEPDELDIARALNRHIAFGQGIHTCLGAPLARLEGDIAFTTLLRRMPGLRLNIPRDNITWHFSLNSQSLAALPIAF
>CP035758.1|QBD76344.1|2201314_2202034_-|MBL-fold-metallo-hydrolase
MKITAHGSHLIQLCYLGMMNCYFIRENDGLTLIDTALASCAKPIMQAAQQLGQPIVRIVLTHAHSDHVGGLDALHELLPEAEVAIMARDARFLKGDMSLDPDEPQVKLRGGYPICKTQPSRLLHEGEHIGSLEVVATPGHTPGHAAFLDTRDRTLIAGDALQTLGGVAVSGTLKPFFPLPALATWHKPSALASARKLLALEPSRLAIGHGRVLEQPQAAMDQAIEVLARELMRQGAKVG
>CP035758.1|QBD76354.1|2213734_2214889_-|methyltransferase-domain-containing-protein
MKEMCMESSAVSETIAECAQLVQEIEQQLGRALQEPVREAFLMVPRHVFVSQYYKQKGSKLEWDLVQASHTQIYRDEPLVTQIDRRGMPSSSSSQPSVMVLQLEALDLQEGQRILEIGTGTGYNAALMGRLVGKSGTVVSIDIDDGLVEEAKRHLFQAGSENVIATVADGYEGYAPLAPYERVIATCGLHRVPRCWLAQLRPGALLVANILLELVSPIIRVKQVGTQTLKGSFLPLEDVRYMPMRQHGEEPASRQGMRWKKYNELPRAEVELAGDLEALLKQAGFALLLHCLVPTVSSHYRWQEGDEQPKMYLLNDRSGETAIQVLGAGTVYAYRDAEDLLNGVRQAMRVFEQLGAPALDRFQVTIEEVQTLIEVDDQVFSLPI
>CP035758.1|QBD76355.1|2216222_2216429_-|hypothetical-protein
MLQRIQCWDHWKEVGRVAQKEYGVSEEDYQRLLPEYQKFLALIANYRVGMLSKDIDRLWHAHILRASP
>CP035758.1|QBD76356.1|2216473_2217184_-|hypothetical-protein
MLFVCDVDGTIAGTLDWTQEEVRETLARMCKEQLGLSFSLEGVCSGKALMQLPEVLSYRQAHEDRWRALIHQYRSSIEGMRDARPMPKAVSGMQQLAQVGAVRYYTIRKSDTDAQLNQSIQETTRAWLAENKFPYPDDVVFCQSFIHKLASVAREEEEQIAFIDDCWQELLEAYTLIAAGEYPKIAHIAEDLKRRLVIVAFGASEIAARHGDLRVVPLPSWENAGNLLHSFEVYPV
>CP035758.1|QBD76357.1|2217202_2217457_-|hypothetical-protein
MRDLPLENVLRGLNDVEREWKLYEDEIIRRAQQQAVVELLYNEVLKLYKDCIELMGQLEKGETVSQEWCKRKDALMMRLQEYSI
>CP035758.1|QBD76358.1|2217453_2217891_-|hypothetical-protein
MISLEDLRAWAEQELEQAQQSSTCVHSETYLTALAAIAEVSGRRGDANDVLLALVQWARARGEMKNAAFIKIRQKIQASCSWVIWRRKREMYVPLGEEGIFNSLYEAWNRTYELWEQTGGHYLVALEGGRFEREMLVRSETGGVW
>CP035758.1|QBD76359.1|2217910_2218807_-|class-I-SAM-dependent-methyltransferase
MVMHLFRFFRRSRVQNVPTHWEPGPLPLTSVKGGRRWREDIPYALPKDLQEKDRLHYQHYVFKTLLGGNYHAPLERVGDMLDVGCGPGYWMLEMARQFPQARICGLDTEFALPHGPVASNCRFVQGNILHGLPFAEESFDYTHQRLLVAALPAQAWPWEIKELLRVTRSGGWVELVEAGDGFSNPGPQTERFLGWVREALRARGIDPSAIAQIGRWLEEAGAHQVFFRTIPCPLGSWAGHEGELWGKDVFAGFHAVKGLVSAQLGIPLQEIELALAKVPQEWAKYHTSNNIYVAYGKK
>CP035758.1|QBD76360.1|2218877_2219093_-|hypothetical-protein
MKSEVARLKQQITLECEAMKHAVSGYAITGKHEMIQHKYNQLGTSQGQLAQIVGEQRAAEIVASIYVETME
>CP035758.1|QBD76361.1|2219468_2220527_+|hypothetical-protein
MWEEYNKVPKSPKRRYVLARLLDISFATFGLDALGGAGLSLEGVETNRVNVPAARARLQKFKQKNHTVGIGNMLENVMGVIYDIHDELPYATGQRQKELLLLLCDFQQFIAGIFRDHSQYDQSLTYQNKAYAIAKSLNDNEVKSLVLWRRGLTYHEQGDLVAASNDLSKALTFNSSSVLLEGGIRASLGHVLAHAATDKTDFLEAFKMLDKAGSLLDAAKKEPDPHFIKFNTEGYQLNRASSWIGVPAKMLRSSENALQEVSLVPVGVGRKRRYAYSSYLQARAWFDTGDYPLATKLAQDALNVASEIKSHVNVNRIHLLYVDLQATKYGKSQEVAALGADLLKAQHPEIFA
>CP035758.1|QBD76362.1|2220634_2221075_+|hypothetical-protein
MDDKQLLLATLQEDWKHAHKAEDKRHIIAALNLILATACQIALALLGFSPRLLPLTLWLIIIGIYGIAASSKLYERSQYHNMRAKEVRGQLDPESVVNQSYQAAEEKHRKHYPVLMHIRLNNIWLGMHVVVALLGLIYTVLCLRGA
>CP035758.1|QBD76363.1|2221167_2222025_-|hypothetical-protein
MAARYLLTSEKNGVALSPLLLAALRFSIASLFFLFPLWRALKQRHVTLRALLVMALLGQLAFSLYYWLQYIGIQETDASISAVLGIGLIPIFTALLARITGKERWGWLFLMCLILGFLGVALVGFQKPPALHPGFFLGVLCLVVNTFLFALYTHLSKQWMQEDIPPVVMTAGTMISGAIGLLFLSLLHPSDWRVIIYLSKVQWAAILFLAVGCSALAYFAYNAALSQMDASRVTIYFYFEPVISIVLAIVLLGEQLTWQTVVGAVAISGAVIVAHAIGRQMHSNR

Crispr_ID: CP035758_13

• CRISPR_ID: CP035758_13
• CRISPR_location: 2212702-2213464
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 10 spacers

Consensus repeat of CP035758_13

Consensus_repeat	Method
GTTACAATCCCTGCCGGGCTCCTCTTTCCCTTCTGAC	PILER-CR
GTCANAAGGGAAAGANGAGCCCGGCAGGGATTGTAAC	CRT

spacers of CP035758_13

>13.1|2212739|35|CP035758|PILER-CR,CRT
TGTACGTAACTATAAGCGCCAGGCCATATAGAAAA
>13.2|2212811|35|CP035758|PILER-CR,CRT
TGACGTCTGATACTTCGGGTATCTCAAGTGCTAAA
>13.3|2212883|38|CP035758|PILER-CR,CRT
TTACAGTAACGGCCTATAACTGGAAGGATCTTTGAGAG
>13.4|2212958|37|CP035758|PILER-CR,CRT
CTTCGTAGAACTCTTCCTTAGCGCGCTGATAATCCTC
>13.5|2213032|34|CP035758|PILER-CR,CRT
CAAGCAAGGCGGCCATGCCAACGTACCCATCGGC
>13.6|2213103|34|CP035758|PILER-CR,CRT
CTTCTTTCCCATTTCACTAATGCTTTCTCTTGTC
>13.7|2213174|38|CP035758|PILER-CR,CRT
CTGCCTTTCTTGAAAGAAATGAACTACGCTGTAGATAT
>13.8|2213249|37|CP035758|CRT
CAAGCGCATCATTCAGATTGGCTAGAGGCCGTATAAG
>13.9|2213323|31|CP035758|CRT
GTCCTACTTCCAAAGGTGCATTAACTCCCGT
>13.10|2213391|37|CP035758|CRT
GTGTGCCAGTCGTGCTGGCTGACCGTCGCCGGATCAG

CRISPR arrays and Neighbor proteins around CP035758_13

CRISPR arrays

The CRISPR arrays of CP035758_13

>merge|CP035758|13|2212702-2213464|PILER-CR,CRT
GTCAGAAGGGAAAGAAGAACCCGGCAGGGATTGTAACTGTACGTAACTATAAGCGCCAGGCCATATAGAAAAGTCAGAAGGGAAAGAAGAACCCGGCAGGAATTGTAACTGACGTCTGATACTTCGGGTATCTCAAGTGCTAAAGTCAGAAGGGAAAGAGGAGCCCGGCAGGGATTGTAACTTACAGTAACGGCCTATAACTGGAAGGATCTTTGAGAGGTCAAAAGGGAAAGAGGAGCCCGACAGGGATTGTAACCTTCGTAGAACTCTTCCTTAGCGCGCTGATAATCCTCGTCAAAAGGGAAAGAAGAGCCCGGCAGGGATTGTAACCAAGCAAGGCGGCCATGCCAACGTACCCATCGGCGTCAGAAGGGAAAGAGGAGCCCGACAGGGATTGTAACCTTCTTTCCCATTTCACTAATGCTTTCTCTTGTCGTCAAAAGGGAAAGAGGAGCCCGACAGGGATTGTAACCTGCCTTTCTTGAAAGAAATGAACTACGCTGTAGATATGTCGGAAGGGAAAGAGGAGCCCGGCAGGGATTGGAACCAAGCGCATCATTCAGATTGGCTAGAGGCCGTATAAGGTCGGAAGGGAAAGAGGAGCCCGGCAGGGATTGTAACGTCCTACTTCCAAAGGTGCATTAACTCCCGTGTCAGAAGGGAAAGAAGAACCCAGCAGGAGTGGAACAGTGTGCCAGTCGTGCTGGCTGACCGTCGCCGGATCAGTTCAAAAGGGAAAGAGGAGCCCGGCAGGGATTGGAAG

>CP035758|13|8|2212702-2213248|PILER-CR
GTCAGAAGGGAAAGAAGAACCCGGCAGGGATTGTAAC	TGTACGTAACTATAAGCGCCAGGCCATATAGAAAA
GTCAGAAGGGAAAGAAGAACCCGGCAGGAATTGTAAC	TGACGTCTGATACTTCGGGTATCTCAAGTGCTAAA
GTCAGAAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC	TTACAGTAACGGCCTATAACTGGAAGGATCTTTGAGAG
GTCAAAAGGGAAAGAGGAGCCCGACAGGGATTGTAAC	CTTCGTAGAACTCTTCCTTAGCGCGCTGATAATCCTC
GTCAAAAGGGAAAGAAGAGCCCGGCAGGGATTGTAAC	CAAGCAAGGCGGCCATGCCAACGTACCCATCGGC
GTCAGAAGGGAAAGAGGAGCCCGACAGGGATTGTAAC	CTTCTTTCCCATTTCACTAATGCTTTCTCTTGTC
GTCAAAAGGGAAAGAGGAGCCCGACAGGGATTGTAAC	CTGCCTTTCTTGAAAGAAATGAACTACGCTGTAGATAT
GTCGGAAGGGAAAGAGGAGCCCGGCAGGGATTGGAAC

>CP035758|13|4|2212702-2213464|CRT
GTCAGAAGGGAAAGAAGAACCCGGCAGGGATTGTAAC	TGTACGTAACTATAAGCGCCAGGCCATATAGAAAA
GTCAGAAGGGAAAGAAGAACCCGGCAGGAATTGTAAC	TGACGTCTGATACTTCGGGTATCTCAAGTGCTAAA
GTCAGAAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC	TTACAGTAACGGCCTATAACTGGAAGGATCTTTGAGAG
GTCAAAAGGGAAAGAGGAGCCCGACAGGGATTGTAAC	CTTCGTAGAACTCTTCCTTAGCGCGCTGATAATCCTC
GTCAAAAGGGAAAGAAGAGCCCGGCAGGGATTGTAAC	CAAGCAAGGCGGCCATGCCAACGTACCCATCGGC
GTCAGAAGGGAAAGAGGAGCCCGACAGGGATTGTAAC	CTTCTTTCCCATTTCACTAATGCTTTCTCTTGTC
GTCAAAAGGGAAAGAGGAGCCCGACAGGGATTGTAAC	CTGCCTTTCTTGAAAGAAATGAACTACGCTGTAGATAT
GTCGGAAGGGAAAGAGGAGCCCGGCAGGGATTGGAAC	CAAGCGCATCATTCAGATTGGCTAGAGGCCGTATAAG
GTCGGAAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC	GTCCTACTTCCAAAGGTGCATTAACTCCCGT
GTCAGAAGGGAAAGAAGAACCCAGCAGGAGTGGAACA	GTGTGCCAGTCGTGCTGGCTGACCGTCGCCGGATCAG
TTCAAAAGGGAAAGAGGAGCCCGGCAGGGATTGGAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD76352.1|2209968_2211015_-|hydroxyacid-dehydrogenase	unknown	unknown	gnl|CDD|240663
CP035758.1|QBD76363.1|2221167_2222025_-|hypothetical-protein	unknown	unknown	gnl|CDD|273359
CP035758.1|QBD76346.1|2204039_2204666_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188483
CP035758.1|QBD76349.1|2206297_2207155_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
CP035758.1|QBD76357.1|2217202_2217457_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76358.1|2217453_2217891_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76359.1|2217910_2218807_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
CP035758.1|QBD76361.1|2219468_2220527_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76356.1|2216473_2217184_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76350.1|2207292_2207964_+|hypothetical-protein	unknown	unknown	gnl|CDD|224996
CP035758.1|QBD76360.1|2218877_2219093_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76347.1|2204742_2205087_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|369571
CP035758.1|QBD76344.1|2201314_2202034_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293807
CP035758.1|QBD76348.1|2205380_2205845_+|hypothetical-protein	unknown	unknown	gnl|CDD|223526
CP035758.1|QBD76354.1|2213734_2214889_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|275041
CP035758.1|QBD76355.1|2216222_2216429_-|hypothetical-protein	unknown	unknown	gnl|CDD|226728
CP035758.1|QBD76345.1|2202690_2203941_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
CP035758.1|QBD76362.1|2220634_2221075_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76351.1|2208218_2209838_-|hypothetical-protein	unknown	unknown	gnl|CDD|223104
CP035758.1|QBD76353.1|2211375_2212155_+|dienelactone-hydrolase-family-protein	unknown	unknown	gnl|CDD|223489

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD76352.1|2209968_2211015_-|hydroxyacid-dehydrogenase	gnl|CDD|240663	cd12187, LDH_like_1, D-Lactate and related Dehydrogenase like proteins, NAD-binding and catalytic domains. D-Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate, and is a member of the 2-hydroxyacid dehydrogenase family. LDH is homologous to D-2-Hydroxyisocaproic acid dehydrogenase(D-HicDH) and shares the 2 domain structure of formate dehydrogenase. D-2-hydroxyisocaproate dehydrogenase-like (HicDH) proteins are NAD-dependent members of the hydroxycarboxylate dehydrogenase family, and share the Rossmann fold typical of many NAD binding proteins. HicDH from Lactobacillus casei forms a monomer and catalyzes the reaction R-CO-COO(-) + NADH + H+ to R-COH-COO(-) + NAD+. D-HicDH, like the structurally distinct L-HicDH, exhibits low side-chain R specificity, accepting a wide range of 2-oxocarboxylic acid side chains. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain.	2.07432e-139
CP035758.1|QBD76363.1|2221167_2222025_-|hypothetical-protein	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.63914e-19
CP035758.1|QBD76346.1|2204039_2204666_+|TetR-family-transcriptional-regulator	gnl|CDD|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	7.64794e-19
CP035758.1|QBD76349.1|2206297_2207155_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.39766e-13
CP035758.1|QBD76359.1|2217910_2218807_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.25926e-13
CP035758.1|QBD76350.1|2207292_2207964_+|hypothetical-protein	gnl|CDD|224996	COG2085, COG2085, Predicted dinucleotide-binding enzymes [General function prediction only].	8.52299e-23
CP035758.1|QBD76347.1|2204742_2205087_-|cupin-domain-containing-protein	gnl|CDD|369571	pfam07883, Cupin_2, Cupin domain. This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).	4.11447e-16
CP035758.1|QBD76344.1|2201314_2202034_-|MBL-fold-metallo-hydrolase	gnl|CDD|293807	cd07721, yflN-like_MBL-fold, uncharacterized subgroup which includes Bacillus subtilis yflN; MBL-fold metallo hydrolase domain. This subgroup includes the uncharacterized Bacillus subtilis yflN protein. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) from which this fold was named are only a small fraction of the activities which are included in this superfamily. Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	1.09348e-65
CP035758.1|QBD76348.1|2205380_2205845_+|hypothetical-protein	gnl|CDD|223526	COG0449, GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane].	0.00560885
CP035758.1|QBD76354.1|2213734_2214889_-|methyltransferase-domain-containing-protein	gnl|CDD|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	4.47995e-61
CP035758.1|QBD76355.1|2216222_2216429_-|hypothetical-protein	gnl|CDD|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	1.65402e-05
CP035758.1|QBD76345.1|2202690_2203941_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	9.90957e-90
CP035758.1|QBD76351.1|2208218_2209838_-|hypothetical-protein	gnl|CDD|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	2.31723e-44
CP035758.1|QBD76353.1|2211375_2212155_+|dienelactone-hydrolase-family-protein	gnl|CDD|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	2.23605e-44

Protein sequences

>CP035758.1|QBD76353.1|2211375_2212155_+|dienelactone-hydrolase-family-protein
MMLDKASEHEIATEHVNVPVDEESATAPLGMYMAQPVEPGSYPGVIVGFELFGLTGYVRKVVERIARLGYVVVAPDFYHRSAPGIELAADAEGRTRGFALLHQLTRQQALNDVRAAMSYLRNVQGCAKLGIVGLSVGGHIAYLAATQLDLKATVAFYAGWLPGTEIPLSRPEPTLALTPGIASHDGYLLFLVGENDALIPREQRAVIATALNEAKVRHELVEYSGAPHGFFCDERESYEPVAAADGWRRLQSLFAAELV
>CP035758.1|QBD76352.1|2209968_2211015_-|hydroxyacid-dehydrogenase
MENNTQQNSSLVHALATTVNEEDGRYLNEHLGHVLSLRLTPALPQDMPASELSEVEILIPFVNTRIGREEIDAMPRLQLIATRSTGYDHIDTGYAAERGIAVANVPGYGETAVAEYTFALLLALSRKLRRILTRQNGTSIEELRGFDLHGKTLGVVGTGAIGLNVIRIANGFGMQVLAYDVRKKHFMAELLNFRYLPLPELLTDSDIITLHVPSLASTYHLLNRQNLPSLKPGALLINTARGTLVETEALVEALDNGILSGAGLDTLEGEEFLQAGDISAPDLQTDEQRKLLELYHSLQQRENVIITPHIAFASKEALKRILDTTIENVLAFLEGRSSNLVTPKAMVH
>CP035758.1|QBD76351.1|2208218_2209838_-|hypothetical-protein
MEKPFIMSEVSTESFITLLAMIGIVIIIAALLSGLIERTGFPQVAVFLVLGAVLGPFGLGVLNIGLDSPILRIVAPLSLVMVLFTDAISLNLNEIRRAGVLTLLVLGPGTLLSAALIALAAWGLLGLPLAAAVLLGAALSSTDPVLLRGLLRRRDIPATARTALSLESSLNDVVLLPIVIVTMTFLQQGHSPSGSDWGHLILDLFVLGPGAGILVGVCAVATLDVVRRHLTVRRDYESLFSLGIAFTAYAAAEAVHGSGFLAAFAAGLTISSLDVELCDCFTEYGETTTEMALLLTFVIFGSSLIWSGIEHITPILVLFAIIALLVRPVAFTVSLSRIRLSRYEKILTAWFGPRGLSSLLLIMLPVFANIPGSTQLFSICSLVVLFSVVVHGGSPFILSRRPPRRKRQIPQGTSPLEEEEATPAVATAPPPAVVPNEPTGTYHGSLITLQPPNRNRNPKKEEAPQFQTADPIRITLDELRQLWHTKARIILLDARKERSYSKSDKQAKGSLRVVPDETIVEQIRELDIPKETWIVAYCT
>CP035758.1|QBD76350.1|2207292_2207964_+|hypothetical-protein
MLELKICNQGEDTMTEEKQIIAVLGASNIGGTLGRKWHAAGHTVAFGVSDPQGKNAQAIRADLGNAVSIGTTTEVLRTNPNVVLIATPPTAVSEIVSANAAHLNGRTIIDATNRIGEAVLYDQQLFQRYVPKAHIFRAFNTLGWENFVNPLFDGVQADLFFCGAPARRAAVDALIRGIGLNPIYLGDVDQAELLDGITKLWFTLALKQGKGRHLAFKVLTDQA
>CP035758.1|QBD76349.1|2206297_2207155_+|GNAT-family-N-acetyltransferase
MSLVQGKMKEGLGEADHAHIRELLRVCHQFDGLEFPLSLEGMLYAPNNVLLCYQHETLLGMVYVMSEGDVELLGLVHPEYRRQGVGRSLLEAAKTFCRRKQVSHLSLVCFEAMPAGEAFCRAVGGQYEKSEFHMVLDMQVLRPLEPLDVALSLRQADAADARTLAHFLAQEFEEAEEEMYSWIEADLKKPGRRAFLVVLGEEPIGTLRMFEDDSSVEITAFGILPPYRRHGYGRRILLQAVHMLLTEGWQHIALDVETENRKALALYLSCGFRQTREDRFYRLDL
>CP035758.1|QBD76348.1|2205380_2205845_+|hypothetical-protein
MPNTLATELENSGRTVEVIAAYVQHYVNERYQQAWQEMLPELEQTYATKGEPAYGLYCIRFFQPLKEELEQVGLQAEQNLPGNFPSSIEEWGPRDYRERRFWTVLRESNGEKLGTLVTRIFHDHTKLRLPQAPAVLPLSQTDDEAIKQFVMQID
>CP035758.1|QBD76347.1|2204742_2205087_-|cupin-domain-containing-protein
MDYTLLQRKELPRDGNTYEFEGKRYGETDISFIWVDMPPGESVRLHRHAYKEIFLVQEGSATYTVGTETLEIQAGQIVIVPAGIPHKFRNSGTVPLKQVDLHLSKQIVTEWLED
>CP035758.1|QBD76346.1|2204039_2204666_+|TetR-family-transcriptional-regulator
MSDTFFTRDDSAQRISLRERKKRLVQTTIEETALRLFQQQGYEQTSIQDIAEAVMMSTRTFFRYFASKEEVLFGPIHTSLYESMRVLQQVAPTATPHAALRTTFMHMADLYQQQRASFLIRYQVAAQTPSIASIYLYTMMEKEPEICDVLCSRLDGSMDYHEMRLLVGMYMAVFRIAVEIWLKQKAQGDLVSLLREYLDLCSSLSHNI
>CP035758.1|QBD76345.1|2202690_2203941_-|cytochrome-P450
MNTPEQATFSLFSGELAENPFTLLAQLRSLGAIVPVPFPLGGTERQVWVVTRMEEAVRILKDHVHFTVDRRIISDTSLFGQNAEEHTNLSAPPSFFSAGTSMLTVDMPDHRRLRTLISKAFTPRYIEGLRPRVQQIADELLNQVQEQGQMDLVEEYAFPLPINVISEMLGVPQADRARVRVWSAALATGLGLGKREPGIIAHIQAFADYAAHLVADKRQHPADDLVSQLTAIEEQGDRLSEAELLSMITLLIFAGHETTSNLIATGTLMLLDHPAQFEKLKADLSLVPLAIEELLRFNGPAMIAGPRYATEEIEVAGQRIQQGDIVIPILRSANRDESQFTEPDELDIARALNRHIAFGQGIHTCLGAPLARLEGDIAFTTLLRRMPGLRLNIPRDNITWHFSLNSQSLAALPIAF
>CP035758.1|QBD76344.1|2201314_2202034_-|MBL-fold-metallo-hydrolase
MKITAHGSHLIQLCYLGMMNCYFIRENDGLTLIDTALASCAKPIMQAAQQLGQPIVRIVLTHAHSDHVGGLDALHELLPEAEVAIMARDARFLKGDMSLDPDEPQVKLRGGYPICKTQPSRLLHEGEHIGSLEVVATPGHTPGHAAFLDTRDRTLIAGDALQTLGGVAVSGTLKPFFPLPALATWHKPSALASARKLLALEPSRLAIGHGRVLEQPQAAMDQAIEVLARELMRQGAKVG
>CP035758.1|QBD76354.1|2213734_2214889_-|methyltransferase-domain-containing-protein
MKEMCMESSAVSETIAECAQLVQEIEQQLGRALQEPVREAFLMVPRHVFVSQYYKQKGSKLEWDLVQASHTQIYRDEPLVTQIDRRGMPSSSSSQPSVMVLQLEALDLQEGQRILEIGTGTGYNAALMGRLVGKSGTVVSIDIDDGLVEEAKRHLFQAGSENVIATVADGYEGYAPLAPYERVIATCGLHRVPRCWLAQLRPGALLVANILLELVSPIIRVKQVGTQTLKGSFLPLEDVRYMPMRQHGEEPASRQGMRWKKYNELPRAEVELAGDLEALLKQAGFALLLHCLVPTVSSHYRWQEGDEQPKMYLLNDRSGETAIQVLGAGTVYAYRDAEDLLNGVRQAMRVFEQLGAPALDRFQVTIEEVQTLIEVDDQVFSLPI
>CP035758.1|QBD76355.1|2216222_2216429_-|hypothetical-protein
MLQRIQCWDHWKEVGRVAQKEYGVSEEDYQRLLPEYQKFLALIANYRVGMLSKDIDRLWHAHILRASP
>CP035758.1|QBD76356.1|2216473_2217184_-|hypothetical-protein
MLFVCDVDGTIAGTLDWTQEEVRETLARMCKEQLGLSFSLEGVCSGKALMQLPEVLSYRQAHEDRWRALIHQYRSSIEGMRDARPMPKAVSGMQQLAQVGAVRYYTIRKSDTDAQLNQSIQETTRAWLAENKFPYPDDVVFCQSFIHKLASVAREEEEQIAFIDDCWQELLEAYTLIAAGEYPKIAHIAEDLKRRLVIVAFGASEIAARHGDLRVVPLPSWENAGNLLHSFEVYPV
>CP035758.1|QBD76357.1|2217202_2217457_-|hypothetical-protein
MRDLPLENVLRGLNDVEREWKLYEDEIIRRAQQQAVVELLYNEVLKLYKDCIELMGQLEKGETVSQEWCKRKDALMMRLQEYSI
>CP035758.1|QBD76358.1|2217453_2217891_-|hypothetical-protein
MISLEDLRAWAEQELEQAQQSSTCVHSETYLTALAAIAEVSGRRGDANDVLLALVQWARARGEMKNAAFIKIRQKIQASCSWVIWRRKREMYVPLGEEGIFNSLYEAWNRTYELWEQTGGHYLVALEGGRFEREMLVRSETGGVW
>CP035758.1|QBD76359.1|2217910_2218807_-|class-I-SAM-dependent-methyltransferase
MVMHLFRFFRRSRVQNVPTHWEPGPLPLTSVKGGRRWREDIPYALPKDLQEKDRLHYQHYVFKTLLGGNYHAPLERVGDMLDVGCGPGYWMLEMARQFPQARICGLDTEFALPHGPVASNCRFVQGNILHGLPFAEESFDYTHQRLLVAALPAQAWPWEIKELLRVTRSGGWVELVEAGDGFSNPGPQTERFLGWVREALRARGIDPSAIAQIGRWLEEAGAHQVFFRTIPCPLGSWAGHEGELWGKDVFAGFHAVKGLVSAQLGIPLQEIELALAKVPQEWAKYHTSNNIYVAYGKK
>CP035758.1|QBD76360.1|2218877_2219093_-|hypothetical-protein
MKSEVARLKQQITLECEAMKHAVSGYAITGKHEMIQHKYNQLGTSQGQLAQIVGEQRAAEIVASIYVETME
>CP035758.1|QBD76361.1|2219468_2220527_+|hypothetical-protein
MWEEYNKVPKSPKRRYVLARLLDISFATFGLDALGGAGLSLEGVETNRVNVPAARARLQKFKQKNHTVGIGNMLENVMGVIYDIHDELPYATGQRQKELLLLLCDFQQFIAGIFRDHSQYDQSLTYQNKAYAIAKSLNDNEVKSLVLWRRGLTYHEQGDLVAASNDLSKALTFNSSSVLLEGGIRASLGHVLAHAATDKTDFLEAFKMLDKAGSLLDAAKKEPDPHFIKFNTEGYQLNRASSWIGVPAKMLRSSENALQEVSLVPVGVGRKRRYAYSSYLQARAWFDTGDYPLATKLAQDALNVASEIKSHVNVNRIHLLYVDLQATKYGKSQEVAALGADLLKAQHPEIFA
>CP035758.1|QBD76362.1|2220634_2221075_+|hypothetical-protein
MDDKQLLLATLQEDWKHAHKAEDKRHIIAALNLILATACQIALALLGFSPRLLPLTLWLIIIGIYGIAASSKLYERSQYHNMRAKEVRGQLDPESVVNQSYQAAEEKHRKHYPVLMHIRLNNIWLGMHVVVALLGLIYTVLCLRGA
>CP035758.1|QBD76363.1|2221167_2222025_-|hypothetical-protein
MAARYLLTSEKNGVALSPLLLAALRFSIASLFFLFPLWRALKQRHVTLRALLVMALLGQLAFSLYYWLQYIGIQETDASISAVLGIGLIPIFTALLARITGKERWGWLFLMCLILGFLGVALVGFQKPPALHPGFFLGVLCLVVNTFLFALYTHLSKQWMQEDIPPVVMTAGTMISGAIGLLFLSLLHPSDWRVIIYLSKVQWAAILFLAVGCSALAYFAYNAALSQMDASRVTIYFYFEPVISIVLAIVLLGEQLTWQTVVGAVAISGAVIVAHAIGRQMHSNR

Crispr_ID: CP035758_14

• CRISPR_ID: CP035758_14
• CRISPR_location: 2215235-2216159
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 12 spacers

Consensus repeat of CP035758_14

Consensus_repeat	Method
GTTACAATCCCTGCCGGGCTCCTCTTTCCCTTTTGAC	PILER-CR
AAGGGAAAGANGANCCCGGCAGGGATTGNAAC	CRT
GGAAAGAGGAGCCCGGCAGGGATTGTAAC	CRISPRCasFinder

spacers of CP035758_14

>14.1|2215272|35|CP035758|PILER-CR
AATAGATATTGCGGAAACAACTGCTTCCGCAAGTT
>14.2|2215344|36|CP035758|PILER-CR
ATCCGGCGTCATGAGTGGGCACTGTCCCCATGAGGT
>14.3|2215417|37|CP035758|PILER-CR
CTTCGTAGAGCTCTTCCTTAGCGCGCTGATAATCCTC
>14.4|2215491|39|CP035758|PILER-CR
TGATCGTCACTGTAAAGACCCGTCCGCGTGGCTGCTTAT
>14.5|2215272|40|CP035758|CRT
AATAGATATTGCGGAAACAACTGCTTCCGCAAGTTGTCAA
>14.6|2215344|41|CP035758|CRT
ATCCGGCGTCATGAGTGGGCACTGTCCCCATGAGGTGTCAA
>14.7|2215417|42|CP035758|CRT
CTTCGTAGAGCTCTTCCTTAGCGCGCTGATAATCCTCGTCAA
>14.8|2215491|44|CP035758|CRT
TGATCGTCACTGTAAAGACCCGTCCGCGTGGCTGCTTATGTCAG
>14.9|2215567|41|CP035758|CRT
TCCTGGATCACATCTCCTACTGAAGTACCACGCAAGGTCGG
>14.10|2215640|40|CP035758|CRT
ATCGCTTAAAGCGGCGGAGCGCTTGGCGAAAGCGGGTCAG
>14.11|2215712|42|CP035758|CRT
AGTAGTTTTTCCCGCCACATATGCGTGCAGCAATTTGAGTCA
>14.12|2215786|42|CP035758|CRT
ATAAGTAATAGAGTGGTACGACATCGGTGCCCTTGACGTCAG
>14.13|2215860|43|CP035758|CRT
TTTCGGAGGGCTTCAACCTCCGACACAGGTCATCTAAAGTCAG
>14.14|2215935|44|CP035758|CRT
CCAATGATATGAATCTTGTTGGACATGAGAACTTTACTCGTCAA
>14.15|2216011|42|CP035758|CRT
AGCATGAGCAACGTTTCGGGACCAGCTTCATAGGAATGTCAA
>14.16|2216085|43|CP035758|CRT
AAGCCGTGTGTCATGTTCGCACGAAAGGCGCGGCGTACGTCAA
>14.17|2215272|43|CP035758|CRISPRCasFinder
AATAGATATTGCGGAAACAACTGCTTCCGCAAGTTGTCAAAAG
>14.18|2215344|44|CP035758|CRISPRCasFinder
ATCCGGCGTCATGAGTGGGCACTGTCCCCATGAGGTGTCAAAAG
>14.19|2215417|45|CP035758|CRISPRCasFinder
CTTCGTAGAGCTCTTCCTTAGCGCGCTGATAATCCTCGTCAAAAA
>14.20|2215491|47|CP035758|CRISPRCasFinder
TGATCGTCACTGTAAAGACCCGTCCGCGTGGCTGCTTATGTCAGAAG
>14.21|2215567|44|CP035758|CRISPRCasFinder
TCCTGGATCACATCTCCTACTGAAGTACCACGCAAGGTCGGAAG
>14.22|2215640|43|CP035758|CRISPRCasFinder
ATCGCTTAAAGCGGCGGAGCGCTTGGCGAAAGCGGGTCAGAAG
>14.23|2215712|45|CP035758|CRISPRCasFinder
AGTAGTTTTTCCCGCCACATATGCGTGCAGCAATTTGAGTCAGAA
>14.24|2215786|45|CP035758|CRISPRCasFinder
ATAAGTAATAGAGTGGTACGACATCGGTGCCCTTGACGTCAGAAG
>14.25|2215860|46|CP035758|CRISPRCasFinder
TTTCGGAGGGCTTCAACCTCCGACACAGGTCATCTAAAGTCAGAAG
>14.26|2215935|47|CP035758|CRISPRCasFinder
CCAATGATATGAATCTTGTTGGACATGAGAACTTTACTCGTCAAAGG
>14.27|2216011|45|CP035758|CRISPRCasFinder
AGCATGAGCAACGTTTCGGGACCAGCTTCATAGGAATGTCAAAAG
>14.28|2216085|46|CP035758|CRISPRCasFinder
AAGCCGTGTGTCATGTTCGCACGAAAGGCGCGGCGTACGTCAAAAA

CRISPR arrays and Neighbor proteins around CP035758_14

CRISPR arrays

The CRISPR arrays of CP035758_14

>merge|CP035758|14|2215235-2216159|PILER-CR,CRT,CRISPRCasFinder
GTCAAAAGGGAAAGAGGAGCCCGGCAGGGATTGTAACAATAGATATTGCGGAAACAACTGCTTCCGCAAGTTGTCAAAAGGGAAAGAGGAGCCCGGCAGGGATTGTAACATCCGGCGTCATGAGTGGGCACTGTCCCCATGAGGTGTCAAAAGGGAAAGAGGAGCCCGGCAGGGATTGTAACCTTCGTAGAGCTCTTCCTTAGCGCGCTGATAATCCTCGTCAAAAAGGAAAGAAGAGCCCGGCAGGGATTGTAACTGATCGTCACTGTAAAGACCCGTCCGCGTGGCTGCTTATGTCAGAAGGGAAAGAGGAGCCCGGCAGGGATTGTAACTCCTGGATCACATCTCCTACTGAAGTACCACGCAAGGTCGGAAGGGAAAGAGGAGCCCGGCAGGGATTGGAACATCGCTTAAAGCGGCGGAGCGCTTGGCGAAAGCGGGTCAGAAGGGAAAGAAGAACCCGGCAAGGATTGGAACAGTAGTTTTTCCCGCCACATATGCGTGCAGCAATTTGAGTCAGAAGGGAAAGAGGAGCCGGCAGGGATTGTAACATAAGTAATAGAGTGGTACGACATCGGTGCCCTTGACGTCAGAAGGGGAAGAAGAACCCGGCAGGGATTGTAACTTTCGGAGGGCTTCAACCTCCGACACAGGTCATCTAAAGTCAGAAGGGAAAGAGGAACCCGGCAGGGATTGTAACCCAATGATATGAATCTTGTTGGACATGAGAACTTTACTCGTCAAAGGGGGAAGAGGGACCCGGTAGGGATTGTAACAGCATGAGCAACGTTTCGGGACCAGCTTCATAGGAATGTCAAAAGGGAAAGAGGGACCCGGCAGGGATTGGAACAAGCCGTGTGTCATGTTCGCACGAAAGGCGCGGCGTACGTCAAAAAGGAAAGAAGAACCCAGCAGGAGTTGGAAG

>CP035758|14|9|2215235-2215566|PILER-CR
GTCAAAAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC	AATAGATATTGCGGAAACAACTGCTTCCGCAAGTT
GTCAAAAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC	ATCCGGCGTCATGAGTGGGCACTGTCCCCATGAGGT
GTCAAAAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC	CTTCGTAGAGCTCTTCCTTAGCGCGCTGATAATCCTC
GTCAAAAAGGAAAGAAGAGCCCGGCAGGGATTGTAAC	TGATCGTCACTGTAAAGACCCGTCCGCGTGGCTGCTTAT
GTCAGAAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC

>CP035758|14|5|2215240-2216159|CRT
AAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC	AATAGATATTGCGGAAACAACTGCTTCCGCAAGTTGTCAA
AAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC	ATCCGGCGTCATGAGTGGGCACTGTCCCCATGAGGTGTCAA
AAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC	CTTCGTAGAGCTCTTCCTTAGCGCGCTGATAATCCTCGTCAA
AAAGGAAAGAAGAGCCCGGCAGGGATTGTAAC	TGATCGTCACTGTAAAGACCCGTCCGCGTGGCTGCTTATGTCAG
AAGGGAAAGAGGAGCCCGGCAGGGATTGTAAC	TCCTGGATCACATCTCCTACTGAAGTACCACGCAAGGTCGG
AAGGGAAAGAGGAGCCCGGCAGGGATTGGAAC	ATCGCTTAAAGCGGCGGAGCGCTTGGCGAAAGCGGGTCAG
AAGGGAAAGAAGAACCCGGCAAGGATTGGAAC	AGTAGTTTTTCCCGCCACATATGCGTGCAGCAATTTGAGTCA
GAAGGGAAAGAGGAGCCGGCAGGGATTGTAAC	ATAAGTAATAGAGTGGTACGACATCGGTGCCCTTGACGTCAG
AAGGGGAAGAAGAACCCGGCAGGGATTGTAAC	TTTCGGAGGGCTTCAACCTCCGACACAGGTCATCTAAAGTCAG
AAGGGAAAGAGGAACCCGGCAGGGATTGTAAC	CCAATGATATGAATCTTGTTGGACATGAGAACTTTACTCGTCAA
AGGGGGAAGAGGGACCCGGTAGGGATTGTAAC	AGCATGAGCAACGTTTCGGGACCAGCTTCATAGGAATGTCAA
AAGGGAAAGAGGGACCCGGCAGGGATTGGAAC	AAGCCGTGTGTCATGTTCGCACGAAAGGCGCGGCGTACGTCAA
AAAGGAAAGAAGAACCCAGCAGGAGTTGGAAG

>CP035758|14|12|2215243-2216159|CRISPRCasFinder
GGAAAGAGGAGCCCGGCAGGGATTGTAAC	AATAGATATTGCGGAAACAACTGCTTCCGCAAGTTGTCAAAAG
GGAAAGAGGAGCCCGGCAGGGATTGTAAC	ATCCGGCGTCATGAGTGGGCACTGTCCCCATGAGGTGTCAAAAG
GGAAAGAGGAGCCCGGCAGGGATTGTAAC	CTTCGTAGAGCTCTTCCTTAGCGCGCTGATAATCCTCGTCAAAAA
GGAAAGAAGAGCCCGGCAGGGATTGTAAC	TGATCGTCACTGTAAAGACCCGTCCGCGTGGCTGCTTATGTCAGAAG
GGAAAGAGGAGCCCGGCAGGGATTGTAAC	TCCTGGATCACATCTCCTACTGAAGTACCACGCAAGGTCGGAAG
GGAAAGAGGAGCCCGGCAGGGATTGGAAC	ATCGCTTAAAGCGGCGGAGCGCTTGGCGAAAGCGGGTCAGAAG
GGAAAGAAGAACCCGGCAAGGATTGGAAC	AGTAGTTTTTCCCGCCACATATGCGTGCAGCAATTTGAGTCAGAA
GGGAAAGAGGAGCCGGCAGGGATTGTAAC	ATAAGTAATAGAGTGGTACGACATCGGTGCCCTTGACGTCAGAAG
GGGAAGAAGAACCCGGCAGGGATTGTAAC	TTTCGGAGGGCTTCAACCTCCGACACAGGTCATCTAAAGTCAGAAG
GGAAAGAGGAACCCGGCAGGGATTGTAAC	CCAATGATATGAATCTTGTTGGACATGAGAACTTTACTCGTCAAAGG
GGGAAGAGGGACCCGGTAGGGATTGTAAC	AGCATGAGCAACGTTTCGGGACCAGCTTCATAGGAATGTCAAAAG
GGAAAGAGGGACCCGGCAGGGATTGGAAC	AAGCCGTGTGTCATGTTCGCACGAAAGGCGCGGCGTACGTCAAAAA
GGAAAGAAGAACCCAGCAGGAGTTGGAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD76352.1|2209968_2211015_-|hydroxyacid-dehydrogenase	unknown	unknown	gnl|CDD|240663
CP035758.1|QBD76363.1|2221167_2222025_-|hypothetical-protein	unknown	unknown	gnl|CDD|273359
CP035758.1|QBD76346.1|2204039_2204666_+|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|188483
CP035758.1|QBD76349.1|2206297_2207155_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
CP035758.1|QBD76357.1|2217202_2217457_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76358.1|2217453_2217891_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76364.1|2222409_2223243_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187572
CP035758.1|QBD76361.1|2219468_2220527_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76356.1|2216473_2217184_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76350.1|2207292_2207964_+|hypothetical-protein	unknown	unknown	gnl|CDD|224996
CP035758.1|QBD76360.1|2218877_2219093_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76347.1|2204742_2205087_-|cupin-domain-containing-protein	unknown	unknown	gnl|CDD|369571
CP035758.1|QBD76359.1|2217910_2218807_-|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
CP035758.1|QBD76348.1|2205380_2205845_+|hypothetical-protein	unknown	unknown	gnl|CDD|223526
CP035758.1|QBD76354.1|2213734_2214889_-|methyltransferase-domain-containing-protein	unknown	unknown	gnl|CDD|275041
CP035758.1|QBD76355.1|2216222_2216429_-|hypothetical-protein	unknown	unknown	gnl|CDD|226728
CP035758.1|QBD76345.1|2202690_2203941_-|cytochrome-P450	unknown	unknown	gnl|CDD|225035
CP035758.1|QBD76362.1|2220634_2221075_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76351.1|2208218_2209838_-|hypothetical-protein	unknown	unknown	gnl|CDD|223104
CP035758.1|QBD76353.1|2211375_2212155_+|dienelactone-hydrolase-family-protein	unknown	unknown	gnl|CDD|223489

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD76352.1|2209968_2211015_-|hydroxyacid-dehydrogenase	gnl|CDD|240663	cd12187, LDH_like_1, D-Lactate and related Dehydrogenase like proteins, NAD-binding and catalytic domains. D-Lactate dehydrogenase (LDH) catalyzes the interconversion of pyruvate and lactate, and is a member of the 2-hydroxyacid dehydrogenase family. LDH is homologous to D-2-Hydroxyisocaproic acid dehydrogenase(D-HicDH) and shares the 2 domain structure of formate dehydrogenase. D-2-hydroxyisocaproate dehydrogenase-like (HicDH) proteins are NAD-dependent members of the hydroxycarboxylate dehydrogenase family, and share the Rossmann fold typical of many NAD binding proteins. HicDH from Lactobacillus casei forms a monomer and catalyzes the reaction R-CO-COO(-) + NADH + H+ to R-COH-COO(-) + NAD+. D-HicDH, like the structurally distinct L-HicDH, exhibits low side-chain R specificity, accepting a wide range of 2-oxocarboxylic acid side chains. Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxyacid dehydrogenase superfamily include groups such as formate dehydrogenase, glycerate dehydrogenase, L-alanine dehydrogenase, and S-Adenosylhomocysteine Hydrolase. Despite often low sequence identity, these proteins typically have a characteristic arrangement of 2 similar subdomains of the alpha/beta Rossmann fold NAD+ binding form. The NAD+ binding domain is inserted within the linear sequence of the mostly N-terminal catalytic domain, which has a similar domain structure to the internal NAD binding domain. Structurally, these domains are connected by extended alpha helices and create a cleft in which NAD is bound, primarily to the C-terminal portion of the 2nd (internal) domain.	2.07432e-139
CP035758.1|QBD76363.1|2221167_2222025_-|hypothetical-protein	gnl|CDD|273359	TIGR00950, Uncharacterized_inner_membrane_transporter_YicL, Carboxylate/Amino Acid/Amine Transporter. [Transport and binding proteins, Amino acids, peptides and amines].	1.63914e-19
CP035758.1|QBD76346.1|2204039_2204666_+|TetR-family-transcriptional-regulator	gnl|CDD|188483	TIGR03968, transcriptional_regulator_TetR_family, mycofactocin system transcriptional regulator. Members of this family are TetR family putative transcriptional regulators that occur in genome contexts near proteins of the mycofactocin system. These include the precursor peptide (TIGR03969), a radical SAM peptide maturase (TIGR03962), and a putative carrier protein (TIGR03967). [Regulatory functions, DNA interactions].	7.64794e-19
CP035758.1|QBD76349.1|2206297_2207155_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	5.39766e-13
CP035758.1|QBD76364.1|2222409_2223243_-|SDR-family-oxidoreductase	gnl|CDD|187572	cd05262, SDR_a7, atypical (a) SDRs, subgroup 7. This subgroup contains atypical SDRs of unknown function. Members of this subgroup have a glycine-rich NAD(P)-binding motif consensus that matches the extended SDRs, TGXXGXXG, but lacks the characteristic active site residues of the SDRs. This subgroup has basic residues (HXXXR) in place of the active site motif YXXXK, these may have a catalytic role. Atypical SDRs generally lack the catalytic residues characteristic of the SDRs, and their glycine-rich NAD(P)-binding motif is often different from the forms normally seen in classical or extended SDRs. Atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), progesterone 5-beta-reductase like proteins, phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.84957e-104
CP035758.1|QBD76350.1|2207292_2207964_+|hypothetical-protein	gnl|CDD|224996	COG2085, COG2085, Predicted dinucleotide-binding enzymes [General function prediction only].	8.52299e-23
CP035758.1|QBD76347.1|2204742_2205087_-|cupin-domain-containing-protein	gnl|CDD|369571	pfam07883, Cupin_2, Cupin domain. This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).	4.11447e-16
CP035758.1|QBD76359.1|2217910_2218807_-|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.25926e-13
CP035758.1|QBD76348.1|2205380_2205845_+|hypothetical-protein	gnl|CDD|223526	COG0449, GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane].	0.00560885
CP035758.1|QBD76354.1|2213734_2214889_-|methyltransferase-domain-containing-protein	gnl|CDD|275041	TIGR04188, conserved_hypothetical_protein, methyltransferase, ATP-grasp peptide maturase system. Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).	4.47995e-61
CP035758.1|QBD76355.1|2216222_2216429_-|hypothetical-protein	gnl|CDD|226728	COG4278, COG4278, Uncharacterized conserved protein [Function unknown].	1.65402e-05
CP035758.1|QBD76345.1|2202690_2203941_-|cytochrome-P450	gnl|CDD|225035	COG2124, CypX, Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism].	9.90957e-90
CP035758.1|QBD76351.1|2208218_2209838_-|hypothetical-protein	gnl|CDD|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	2.31723e-44
CP035758.1|QBD76353.1|2211375_2212155_+|dienelactone-hydrolase-family-protein	gnl|CDD|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	2.23605e-44

Protein sequences

>CP035758.1|QBD76354.1|2213734_2214889_-|methyltransferase-domain-containing-protein
MKEMCMESSAVSETIAECAQLVQEIEQQLGRALQEPVREAFLMVPRHVFVSQYYKQKGSKLEWDLVQASHTQIYRDEPLVTQIDRRGMPSSSSSQPSVMVLQLEALDLQEGQRILEIGTGTGYNAALMGRLVGKSGTVVSIDIDDGLVEEAKRHLFQAGSENVIATVADGYEGYAPLAPYERVIATCGLHRVPRCWLAQLRPGALLVANILLELVSPIIRVKQVGTQTLKGSFLPLEDVRYMPMRQHGEEPASRQGMRWKKYNELPRAEVELAGDLEALLKQAGFALLLHCLVPTVSSHYRWQEGDEQPKMYLLNDRSGETAIQVLGAGTVYAYRDAEDLLNGVRQAMRVFEQLGAPALDRFQVTIEEVQTLIEVDDQVFSLPI
>CP035758.1|QBD76353.1|2211375_2212155_+|dienelactone-hydrolase-family-protein
MMLDKASEHEIATEHVNVPVDEESATAPLGMYMAQPVEPGSYPGVIVGFELFGLTGYVRKVVERIARLGYVVVAPDFYHRSAPGIELAADAEGRTRGFALLHQLTRQQALNDVRAAMSYLRNVQGCAKLGIVGLSVGGHIAYLAATQLDLKATVAFYAGWLPGTEIPLSRPEPTLALTPGIASHDGYLLFLVGENDALIPREQRAVIATALNEAKVRHELVEYSGAPHGFFCDERESYEPVAAADGWRRLQSLFAAELV
>CP035758.1|QBD76352.1|2209968_2211015_-|hydroxyacid-dehydrogenase
MENNTQQNSSLVHALATTVNEEDGRYLNEHLGHVLSLRLTPALPQDMPASELSEVEILIPFVNTRIGREEIDAMPRLQLIATRSTGYDHIDTGYAAERGIAVANVPGYGETAVAEYTFALLLALSRKLRRILTRQNGTSIEELRGFDLHGKTLGVVGTGAIGLNVIRIANGFGMQVLAYDVRKKHFMAELLNFRYLPLPELLTDSDIITLHVPSLASTYHLLNRQNLPSLKPGALLINTARGTLVETEALVEALDNGILSGAGLDTLEGEEFLQAGDISAPDLQTDEQRKLLELYHSLQQRENVIITPHIAFASKEALKRILDTTIENVLAFLEGRSSNLVTPKAMVH
>CP035758.1|QBD76351.1|2208218_2209838_-|hypothetical-protein
MEKPFIMSEVSTESFITLLAMIGIVIIIAALLSGLIERTGFPQVAVFLVLGAVLGPFGLGVLNIGLDSPILRIVAPLSLVMVLFTDAISLNLNEIRRAGVLTLLVLGPGTLLSAALIALAAWGLLGLPLAAAVLLGAALSSTDPVLLRGLLRRRDIPATARTALSLESSLNDVVLLPIVIVTMTFLQQGHSPSGSDWGHLILDLFVLGPGAGILVGVCAVATLDVVRRHLTVRRDYESLFSLGIAFTAYAAAEAVHGSGFLAAFAAGLTISSLDVELCDCFTEYGETTTEMALLLTFVIFGSSLIWSGIEHITPILVLFAIIALLVRPVAFTVSLSRIRLSRYEKILTAWFGPRGLSSLLLIMLPVFANIPGSTQLFSICSLVVLFSVVVHGGSPFILSRRPPRRKRQIPQGTSPLEEEEATPAVATAPPPAVVPNEPTGTYHGSLITLQPPNRNRNPKKEEAPQFQTADPIRITLDELRQLWHTKARIILLDARKERSYSKSDKQAKGSLRVVPDETIVEQIRELDIPKETWIVAYCT
>CP035758.1|QBD76350.1|2207292_2207964_+|hypothetical-protein
MLELKICNQGEDTMTEEKQIIAVLGASNIGGTLGRKWHAAGHTVAFGVSDPQGKNAQAIRADLGNAVSIGTTTEVLRTNPNVVLIATPPTAVSEIVSANAAHLNGRTIIDATNRIGEAVLYDQQLFQRYVPKAHIFRAFNTLGWENFVNPLFDGVQADLFFCGAPARRAAVDALIRGIGLNPIYLGDVDQAELLDGITKLWFTLALKQGKGRHLAFKVLTDQA
>CP035758.1|QBD76349.1|2206297_2207155_+|GNAT-family-N-acetyltransferase
MSLVQGKMKEGLGEADHAHIRELLRVCHQFDGLEFPLSLEGMLYAPNNVLLCYQHETLLGMVYVMSEGDVELLGLVHPEYRRQGVGRSLLEAAKTFCRRKQVSHLSLVCFEAMPAGEAFCRAVGGQYEKSEFHMVLDMQVLRPLEPLDVALSLRQADAADARTLAHFLAQEFEEAEEEMYSWIEADLKKPGRRAFLVVLGEEPIGTLRMFEDDSSVEITAFGILPPYRRHGYGRRILLQAVHMLLTEGWQHIALDVETENRKALALYLSCGFRQTREDRFYRLDL
>CP035758.1|QBD76348.1|2205380_2205845_+|hypothetical-protein
MPNTLATELENSGRTVEVIAAYVQHYVNERYQQAWQEMLPELEQTYATKGEPAYGLYCIRFFQPLKEELEQVGLQAEQNLPGNFPSSIEEWGPRDYRERRFWTVLRESNGEKLGTLVTRIFHDHTKLRLPQAPAVLPLSQTDDEAIKQFVMQID
>CP035758.1|QBD76347.1|2204742_2205087_-|cupin-domain-containing-protein
MDYTLLQRKELPRDGNTYEFEGKRYGETDISFIWVDMPPGESVRLHRHAYKEIFLVQEGSATYTVGTETLEIQAGQIVIVPAGIPHKFRNSGTVPLKQVDLHLSKQIVTEWLED
>CP035758.1|QBD76346.1|2204039_2204666_+|TetR-family-transcriptional-regulator
MSDTFFTRDDSAQRISLRERKKRLVQTTIEETALRLFQQQGYEQTSIQDIAEAVMMSTRTFFRYFASKEEVLFGPIHTSLYESMRVLQQVAPTATPHAALRTTFMHMADLYQQQRASFLIRYQVAAQTPSIASIYLYTMMEKEPEICDVLCSRLDGSMDYHEMRLLVGMYMAVFRIAVEIWLKQKAQGDLVSLLREYLDLCSSLSHNI
>CP035758.1|QBD76345.1|2202690_2203941_-|cytochrome-P450
MNTPEQATFSLFSGELAENPFTLLAQLRSLGAIVPVPFPLGGTERQVWVVTRMEEAVRILKDHVHFTVDRRIISDTSLFGQNAEEHTNLSAPPSFFSAGTSMLTVDMPDHRRLRTLISKAFTPRYIEGLRPRVQQIADELLNQVQEQGQMDLVEEYAFPLPINVISEMLGVPQADRARVRVWSAALATGLGLGKREPGIIAHIQAFADYAAHLVADKRQHPADDLVSQLTAIEEQGDRLSEAELLSMITLLIFAGHETTSNLIATGTLMLLDHPAQFEKLKADLSLVPLAIEELLRFNGPAMIAGPRYATEEIEVAGQRIQQGDIVIPILRSANRDESQFTEPDELDIARALNRHIAFGQGIHTCLGAPLARLEGDIAFTTLLRRMPGLRLNIPRDNITWHFSLNSQSLAALPIAF
>CP035758.1|QBD76355.1|2216222_2216429_-|hypothetical-protein
MLQRIQCWDHWKEVGRVAQKEYGVSEEDYQRLLPEYQKFLALIANYRVGMLSKDIDRLWHAHILRASP
>CP035758.1|QBD76356.1|2216473_2217184_-|hypothetical-protein
MLFVCDVDGTIAGTLDWTQEEVRETLARMCKEQLGLSFSLEGVCSGKALMQLPEVLSYRQAHEDRWRALIHQYRSSIEGMRDARPMPKAVSGMQQLAQVGAVRYYTIRKSDTDAQLNQSIQETTRAWLAENKFPYPDDVVFCQSFIHKLASVAREEEEQIAFIDDCWQELLEAYTLIAAGEYPKIAHIAEDLKRRLVIVAFGASEIAARHGDLRVVPLPSWENAGNLLHSFEVYPV
>CP035758.1|QBD76357.1|2217202_2217457_-|hypothetical-protein
MRDLPLENVLRGLNDVEREWKLYEDEIIRRAQQQAVVELLYNEVLKLYKDCIELMGQLEKGETVSQEWCKRKDALMMRLQEYSI
>CP035758.1|QBD76358.1|2217453_2217891_-|hypothetical-protein
MISLEDLRAWAEQELEQAQQSSTCVHSETYLTALAAIAEVSGRRGDANDVLLALVQWARARGEMKNAAFIKIRQKIQASCSWVIWRRKREMYVPLGEEGIFNSLYEAWNRTYELWEQTGGHYLVALEGGRFEREMLVRSETGGVW
>CP035758.1|QBD76359.1|2217910_2218807_-|class-I-SAM-dependent-methyltransferase
MVMHLFRFFRRSRVQNVPTHWEPGPLPLTSVKGGRRWREDIPYALPKDLQEKDRLHYQHYVFKTLLGGNYHAPLERVGDMLDVGCGPGYWMLEMARQFPQARICGLDTEFALPHGPVASNCRFVQGNILHGLPFAEESFDYTHQRLLVAALPAQAWPWEIKELLRVTRSGGWVELVEAGDGFSNPGPQTERFLGWVREALRARGIDPSAIAQIGRWLEEAGAHQVFFRTIPCPLGSWAGHEGELWGKDVFAGFHAVKGLVSAQLGIPLQEIELALAKVPQEWAKYHTSNNIYVAYGKK
>CP035758.1|QBD76360.1|2218877_2219093_-|hypothetical-protein
MKSEVARLKQQITLECEAMKHAVSGYAITGKHEMIQHKYNQLGTSQGQLAQIVGEQRAAEIVASIYVETME
>CP035758.1|QBD76361.1|2219468_2220527_+|hypothetical-protein
MWEEYNKVPKSPKRRYVLARLLDISFATFGLDALGGAGLSLEGVETNRVNVPAARARLQKFKQKNHTVGIGNMLENVMGVIYDIHDELPYATGQRQKELLLLLCDFQQFIAGIFRDHSQYDQSLTYQNKAYAIAKSLNDNEVKSLVLWRRGLTYHEQGDLVAASNDLSKALTFNSSSVLLEGGIRASLGHVLAHAATDKTDFLEAFKMLDKAGSLLDAAKKEPDPHFIKFNTEGYQLNRASSWIGVPAKMLRSSENALQEVSLVPVGVGRKRRYAYSSYLQARAWFDTGDYPLATKLAQDALNVASEIKSHVNVNRIHLLYVDLQATKYGKSQEVAALGADLLKAQHPEIFA
>CP035758.1|QBD76362.1|2220634_2221075_+|hypothetical-protein
MDDKQLLLATLQEDWKHAHKAEDKRHIIAALNLILATACQIALALLGFSPRLLPLTLWLIIIGIYGIAASSKLYERSQYHNMRAKEVRGQLDPESVVNQSYQAAEEKHRKHYPVLMHIRLNNIWLGMHVVVALLGLIYTVLCLRGA
>CP035758.1|QBD76363.1|2221167_2222025_-|hypothetical-protein
MAARYLLTSEKNGVALSPLLLAALRFSIASLFFLFPLWRALKQRHVTLRALLVMALLGQLAFSLYYWLQYIGIQETDASISAVLGIGLIPIFTALLARITGKERWGWLFLMCLILGFLGVALVGFQKPPALHPGFFLGVLCLVVNTFLFALYTHLSKQWMQEDIPPVVMTAGTMISGAIGLLFLSLLHPSDWRVIIYLSKVQWAAILFLAVGCSALAYFAYNAALSQMDASRVTIYFYFEPVISIVLAIVLLGEQLTWQTVVGAVAISGAVIVAHAIGRQMHSNR
>CP035758.1|QBD76364.1|2222409_2223243_-|SDR-family-oxidoreductase
MRVFVTGATGFVGSAVVSELLAAGHQVVGLTRSDNGARALEESGAEVHHGTLDDLGSLRTAAAAVDGIIHLAFGQNLPDFAAALTTDLHAVETMGKALEGTGKPFVITAHLNGEASDNTVLSLAGVRASIVTLSPFVHGKGDKRGFMPRLISIARERGTSAYVGDGSNRWPAIHRLDAARLFRLALESGPGGSQLQGVGEEGVPFRDIASVIGRHLNLPVVSLSPKEADAHFSSLSSLSALVALDLPRSSAQTQELLGWRPLHLGLLADLEEHYFNN

Crispr_ID: CP035758_15

• CRISPR_ID: CP035758_15
• CRISPR_location: 2498557-2498813
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of CP035758_15

Consensus_repeat	Method
CCCGAAAGGGAGAGAAGAGCCTGGCAGGGATTGGAAC	CRISPRCasFinder

spacers of CP035758_15

>15.1|2498594|36|CP035758|CRISPRCasFinder
CGGTTGAAATTTCAGGCGGCATCGTCCCAAAGAGCC
>15.2|2498667|35|CP035758|CRISPRCasFinder
TTCACGAATAACAATGGGCTCAATCAACCCATGTT
>15.3|2498739|38|CP035758|CRISPRCasFinder
GCTTGTAGCCGATGTAAATCAAAGGAGAATATGCTGCC

CRISPR arrays and Neighbor proteins around CP035758_15

CRISPR arrays

The CRISPR arrays of CP035758_15

>merge|CP035758|15|2498557-2498813|CRISPRCasFinder
CCCGAAAGGGAGAGAAGAGCCTGGCAGGGATTGGAACCGGTTGAAATTTCAGGCGGCATCGTCCCAAAGAGCCCCCGAAAGGGAGAGAAGAGCCTGGCAGGGATTGGAACTTCACGAATAACAATGGGCTCAATCAACCCATGTTCCCGAAAGGGAGAGAAGAACCCGGCAGGGATTGTAACGCTTGTAGCCGATGTAAATCAAAGGAGAATATGCTGCCCCCAAAAGGGAGAGAAGAGCCCGGCAGGGATTGTAAC

>CP035758|15|13|2498557-2498813|CRISPRCasFinder
CCCGAAAGGGAGAGAAGAGCCTGGCAGGGATTGGAAC	CGGTTGAAATTTCAGGCGGCATCGTCCCAAAGAGCC
CCCGAAAGGGAGAGAAGAGCCTGGCAGGGATTGGAAC	TTCACGAATAACAATGGGCTCAATCAACCCATGTT
CCCGAAAGGGAGAGAAGAACCCGGCAGGGATTGTAAC	GCTTGTAGCCGATGTAAATCAAAGGAGAATATGCTGCC
CCCAAAAGGGAGAGAAGAGCCCGGCAGGGATTGTAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD76592.1|2506167_2506812_-|isochorismatase-family-protein	unknown	unknown	gnl|CDD|238494
CP035758.1|QBD76581.1|2494642_2495326_+|hypothetical-protein	unknown	unknown	gnl|CDD|225312
CP035758.1|QBD76589.1|2502960_2504469_-|IS66-family-transposase	unknown	unknown	gnl|CDD|376980
CP035758.1|QBD76583.1|2496019_2496595_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76580.1|2491005_2494272_-|hypothetical-protein	unknown	unknown	gnl|CDD|225461
CP035758.1|QBD76584.1|2497076_2498195_-|DNA-topoisomerase-IB	unknown	unknown	gnl|CDD|226099
CP035758.1|QBD76579.1|2489120_2490761_-|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|235704
CP035758.1|QBD76577.1|2488391_2488646_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76576.1|2488056_2488275_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76591.1|2504960_2505827_-|EamA-family-transporter	unknown	unknown	gnl|CDD|274527
CP035758.1|QBD76582.1|2495494_2495773_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379188
CP035758.1|QBD76594.1|2508225_2509572_+|MFS-transporter	unknown	unknown	gnl|CDD|340863
CP035758.1|QBD76588.1|2502098_2502629_+|hypothetical-protein	unknown	unknown	gnl|CDD|284659
CP035758.1|QBD76593.1|2506992_2507589_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
CP035758.1|QBD76578.1|2488665_2489049_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76585.1|2498829_2499756_+|haloacid-dehalogenase-like-hydrolase	unknown	unknown	unknown
CP035758.1|QBD76586.1|2499877_2500624_-|nicotinamide-nucleotide-amidohydrolase-family-protein	unknown	unknown	gnl|CDD|234789
CP035758.1|QBD76575.1|2486766_2487888_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
CP035758.1|QBD76590.1|2504586_2504847_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76587.1|2501466_2501799_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD76581.1|2494642_2495326_+|hypothetical-protein	gnl|CDD|225312	COG2514, COG2514, Predicted ring-cleavage extradiol dioxygenase [General function prediction only].	2.37132e-09
CP035758.1|QBD76589.1|2502960_2504469_-|IS66-family-transposase	gnl|CDD|376980	pfam03050, DDE_Tnp_IS66, Transposase IS66 family. Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.	7.26585e-50
CP035758.1|QBD76591.1|2504960_2505827_-|EamA-family-transporter	gnl|CDD|274527	TIGR03340, phn_DUF6, phosphonate utilization associated putative membrane protein. This family of hydrophobic proteins has some homology to families of integral membrane proteins such as (pfam00892) and may be a permease. It occurs in the vicinity of various types of operons for the catabolism of phosphonates in Vibrio, Pseudomonas, Polaromonas and Thiomicrospira.	4.7759e-27
CP035758.1|QBD76580.1|2491005_2494272_-|hypothetical-protein	gnl|CDD|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	2.93068e-101
CP035758.1|QBD76579.1|2489120_2490761_-|FAD-dependent-oxidoreductase	gnl|CDD|235704	PRK06126, PRK06126, hypothetical protein; Provisional.	2.39535e-114
CP035758.1|QBD76588.1|2502098_2502629_+|hypothetical-protein	gnl|CDD|284659	pfam07291, MauE, Methylamine utilisation protein MauE. This family consists of several bacterial methylamine utilisation MauE proteins. Synthesis of enzymes involved in methylamine oxidation via methylamine dehydrogenase (MADH) is encoded by genes present in the mau cluster. MauE and MauD are specifically involved in the processing, transport, and/or maturation of the beta-subunit and that the absence of each of these proteins leads to production of a non-functional beta-subunit which becomes rapidly degraded.	7.07049e-05
CP035758.1|QBD76592.1|2506167_2506812_-|isochorismatase-family-protein	gnl|CDD|238494	cd01012, YcaC_related, YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.	1.08476e-40
CP035758.1|QBD76582.1|2495494_2495773_-|XRE-family-transcriptional-regulator	gnl|CDD|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	0.000109514
CP035758.1|QBD76594.1|2508225_2509572_+|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.06785e-74
CP035758.1|QBD76593.1|2506992_2507589_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.5945e-11
CP035758.1|QBD76586.1|2499877_2500624_-|nicotinamide-nucleotide-amidohydrolase-family-protein	gnl|CDD|234789	PRK00549, PRK00549, competence damage-inducible protein A; Provisional.	2.87334e-56
CP035758.1|QBD76575.1|2486766_2487888_-|XRE-family-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.49344e-07
CP035758.1|QBD76584.1|2497076_2498195_-|DNA-topoisomerase-IB	gnl|CDD|226099	COG3569, COG3569, Topoisomerase IB [DNA replication, recombination, and repair].	3.60954e-118

Protein sequences

>CP035758.1|QBD76584.1|2497076_2498195_-|DNA-topoisomerase-IB
MTASLKHHTQPVSEASQTCATADASEVAQEAGLLYVSDTAMPGITRKRVGKHFTYKDTHGRPIHDPTELKRIKSLGIPPAWTDVWICPYPQGHLQATGRDAKKRKQYRYHPHWRQVRDTTKYDSLIAFGETLPIIRKRISQDLALRGLPQAKVLATIVRLLDTTLIRVGNEEYARENASYGLTTLRNRHVDIDGSQVIFHFRGKSGKEHVIDVKDKQLARIVKRCQDLPGHVLFEYRDEDEQLRTVDSSDVNDYLRSISGQDFSAKDFRTWGGSIIAAHALKDLGGFENQTQAKKQIAEAIKTAASDLGNTPAICRKCYVHPAIIEGYLDGSLLPFLNERAKKVISKAPDELHDDEAIVLAFLKQAIHNEKA
>CP035758.1|QBD76583.1|2496019_2496595_-|hypothetical-protein
MNFYLLALFIHILGVIMLFVAIGFEWTSLLRLQRAQTIAQVYEYTGLLTFQTFFLGAGVLLAILTGIYMTIIKWSWGTGWIDIALLIIVMDGILAARINLPGLKAIREAAQISETASSSGNISQQLEFMISQPVLCISVQIHAITSLGIVFLMSVKPELPGALIAFAASLLVSFIAAQLIRRGTPQTVPNI
>CP035758.1|QBD76582.1|2495494_2495773_-|XRE-family-transcriptional-regulator
MPVTCHLRILLARLNVEHAKQGKPTISLRRLSEESGVSLSVLVSLHTGQSHRIDYTTVDRLLTYFNRSLPVSMNDLLVWEPAVQDEATLAAV
>CP035758.1|QBD76581.1|2494642_2495326_+|hypothetical-protein
MRIAEISLCAPDLVTQQEFYTGILGLPLVQATDTSFTVQAGETRLNFQPIKRGRALYHFAFAIPCNKFAQAEEWLKKRVPILGRGGKETFFWPEWNAASMYFYDANGNVVELITHYDLAVQASGEFGPQDLLYVSEISLVVDDVPMRIGRLKAKLGLETYRCCEDTCALLGDIHGLFTVVQAGYLWFPTRNKEALVTPVCVKLDGRQEQHLRFSPFPYTIDVVPTIS
>CP035758.1|QBD76580.1|2491005_2494272_-|hypothetical-protein
MPKQAQYHLHWSPAKGQYELWEQNQLIYTFQEQERGWWFSWLGTHSSFSFQGKQGKLTLLKEPRARGTVYWYAYRSHKRRTVKQYAGRTSDLSPTHLEEIASSFAQKVSAPAELAVPVDKTVATSQNYHLQRDNKKKQSTNRQESIASPPLSSPTAQPLPLLQQKFQPPLPHISLIERKALLQKLDTIRDHKLTLITAPAGFGKTTAISQWMERNRRQEHAQPVAWLSLEQHDNDLLRFWRYLAGACQSLYAEPAQASYELLATDLFSFEIPSHELILTLLLNDIVRHGCHGILILDDYHLITDIHIHEMLTFSLDHLPPQLHMVLIGRSTPSIALAGLRSRGDLYEIQTADLRFSLQETTEFLQRLSAPALSQLPPTLSAQISTRLEGWAAGLRLLALSLQGSAAQQDLEHILMTFTGEQRAFQDYFLTEVLRAQSAERQDFLLRTSMLDRLTAEICNAVTKRSNSQLLLEEIERAGIFLEALDQAGIWYRYHALFAEAMQLEARRRLGEDVLHNLALRASQWYAQQGMHTQAVEAAFQAEDTARAAKLIEDILIREKYLILSLQSFQQENGFHTLRRWLTQLPESLLRKHPILFLGYAAALLFTLIVERPALSQGYTAKLDESVFSMQAFWATIEHLLQMAEEEFRAIMDGPRLGQTLAFRALIAREQGNLREAISYAEKSLNLLTEEEAGWYNLSLNVIGMGKIAAGQLEEAKQIFLELYALCEMLGGKRAILRAHTVLLNTINYEQGKLRQSAEYFRQMLAEAREDNDEDDIAHASLFLARLSYEWNDMQSAEEQAQEALNCGRILGNEEFEVQASLVLAHIEHARGETERARQRCRALLVRFPATSQLRTRLNREIQMTQVSFSLDLGDVSSAELWQSNLDMHMELPLIQREQEELLAARCQLVQGHTTAARNALLNLLTEAQQMGHMRSALRIQAALVLAWLAAGNIAQTRETLQTLLSYAHTEGYVRLFLDSGESMIRLLRVSLPQLREQTLIAYTHQILKAAAPTTTPSTLAYTLLAEPLSAQEERVLRELLAGRTNPEIARKLIISINTVKAHLKSIYRKLHVETRQQACEAARKLEFR
>CP035758.1|QBD76579.1|2489120_2490761_-|FAD-dependent-oxidoreductase
MTQEHVPVLIVGGGIVGLSASLFLSEHGIRSLLVERHRGTSIHPRARGVNARTMELYRELGIAEAVRAAGAELAPSMGIFKGRALFEVIEPRRRKEGKRKLPAAGLFQKLGPVAGARGTQDKIEPVLLQAAREHGGDLRFYTELIEFAQDETGVTATIRERESGTLSTIRADYLLAADGASSPTRQMLGVSTSGRGVLGHLLNILFQADLHELVRGREFSLCQIERPEVRGLFTSINNSDLWVFHLSYDPNLGEQAADFPAERCKELLHIALGLPDIEIEIKSILPWQSAVRVADGFQHGRVFLAGDAAHQMPPWGGQGANTGVADAHNLAWKLAAVLKGKAGPELLSTYDSERRPVGRLAAEESGAAADEHGLISMKKSLTHIIGMVRRMPRLLGYGYEYTSQAIISAGSPAQGIVRQLLSGTLGLDGRPGTRAPHIWVQYQGQRISTLDLFGKNFVLLTGSAGADWLQAAVAVREHLDVELDAYRIGPSGELLADQKQWPARAGISEYGALLIRPDGFVAWRSREQPGNPQAALEQVLKQVLFR
>CP035758.1|QBD76578.1|2488665_2489049_+|hypothetical-protein
MSGTFDNRKREAASSQHPQTETISLVVDRHAIHEHVLALIADQKQTWITYEPWGGTHWRVHIRGSGRAVSQDEVPDLLTAMQDAHAVLILKSCIMPQLLFLQSPSGRLLYGEDLLWRQRSFLTIAPE
>CP035758.1|QBD76577.1|2488391_2488646_+|hypothetical-protein
MMELDISQQDTLPLPLLDSLRAYMERHHLTWVAVARLSGVRVITVWRMWSDLPVSTADAMRVRVAVQCFTGYAYLGPLLTYELL
>CP035758.1|QBD76576.1|2488056_2488275_+|hypothetical-protein
MKENTSEVVQLLDRIDQEYQAAQWALKGLAYGTARHDFINERLVNLQALHEQIIEQVGPDAAPQLIARAYSS
>CP035758.1|QBD76575.1|2486766_2487888_-|XRE-family-transcriptional-regulator
MSGRDAKPRPPTALGRALKIYRDQHKFTQEQLAALLDEDTRQIRRWENAETQLTDTRELKRIADRLGIPYKDLGIATSIYAPIRLDEIDTKVDRIWNLVDKAHVDEAYAVAENLILEASQHTGTSDILALRTLARMYHATAHAASLSLKTEEVGHILYYYQQMEYFAQQLKDDTLINISLAYQGDMLRRKGDIANAIHYLERARDTTPLADKAAQGNALQLLARTYMQGYKLENFDRTIKEAEDLARSIDQQNNSVRQFNLGYVFEEYAKSFCRLGKTQRALDYIDQAEKYRNPTKSSEILMKVARAEILVREGDVRNATPLAIQAATYSREHGHNRRLERIYAIKRYMYQQVTKYSKAEWELNEALEGPNEY
>CP035758.1|QBD76585.1|2498829_2499756_+|haloacid-dehalogenase-like-hydrolase
MHKRYLDCNASELRSISKPDLLDALRASEGRIVVSETIGAVQPLLQTITNAELAASQGADVLLLNLLDVDTPAIHGMPAGIEPEDIIHALQHLTGRVIGVNLEAVDPAFRQEQGSLWDIKEGRVASARNAQKLLTMGAKFIVLTGNPGNGITNSAITSSLQEIHAAVGEKIILVAGKMHAAGVLSEGGESILTLDDITEFRESGADIILLPAPGTVPGITLEYARGLIVHAHKLGAMAMTAIGTSQEGANIETIRHIALMCKMAGADLHHIGDTGYVGIALPENINAYSIAIRGIRHTYARMARSVNR
>CP035758.1|QBD76586.1|2499877_2500624_-|nicotinamide-nucleotide-amidohydrolase-family-protein
MNKQNICTRTFYIVELKEETIRKRLQALLELADPELSIQNSAQYITLRLCTQAPTRAEGEGLLDRAEQRIRALLTNYVLSAEEASLQKIIGTYLDKGPLTVSTMESLTGGLIASALTDVHESAAHFIGGIVSYSTPLKERMGVPHETIEQYGVVSEETARAMAQAVRKFLDTDIGLGITGIAGPDKQEDKPVGTVYIAIDGPYGMLTGTGSERCAGPEREENKQAAAISALNLLRRYLERRASPASQD
>CP035758.1|QBD76587.1|2501466_2501799_+|hypothetical-protein
MEQSQKRIGGKPLPPPPSGPPPWFKDVPGTLEVKVRVLTRDHPEYEGSKHRIQTVDRFLANSPKASNGNPYTIEWMDPFHGKKHTIDLTQWATDARDALVNIECSFHPAK
>CP035758.1|QBD76588.1|2502098_2502629_+|hypothetical-protein
MIFNLFTGTLYKQGILPLWSIKWVSKIFPWIEIGLSLLLTAGFLEKLVSFLVVSLFVIFLSIKLTLFFKKAHVSCGCNSQSTSEVVDGVSIFVAIIYIALSTFHMILAVLNTPISIFWHLVESGCIILLWSLLLIGCIIHYKRQLKINPQEVEVTSQKPVFFFRDEEGNTLTIIDY
>CP035758.1|QBD76589.1|2502960_2504469_-|IS66-family-transposase
MNKDDELEQLRQENDALRHTNRTLHECVRESIQAIGSLHKQIKELEGVIASQQEHIKALEGQVAKDSHNSSLPPSSDRFVRVPKSLRQPSGKKPGGQKGHRGHHLRQVQTPDEILVHPVLACSHCHRDLSGLPAALPERRQVIDLPSQRLWIKEHRVEEKQCPVCYHLTRASFPASVKAPTQYGRGIQTLATYLVQGQALPYARASQLLQELLGVQLSAGSIASFVKTCYHQLEEVETRLRAAVVKAKVLNQDETGMRVGTEGWWVHVCSTARLTYYAAHPSRGRVALDAIGIAPQFRGTSVHDGLQSYQSYCFTQALCNVHHLRELTFIEEELGQVWARAMKELLLDMKAEVERAKTHGQPQLDLLVLARLLCRYDEILAEGYLAHPPPGPPKKSAQGKRLPGRAKQSPARNLLDRFSQRKWEVLRFLHDFAVPFDNNQAERDLRMIKVQQKVSGCFRTELGIAMFCRIRSYLSTLRKQGIALFSAFDHLFSGTPVLPAFS
>CP035758.1|QBD76590.1|2504586_2504847_-|hypothetical-protein
MNKQNICTRTFYIVELKEETIRKRLQALLELADPELSIQNSAQYITLRLCTQAPTLAEGEGSLTALSHLPNDLALQAFCSACLLST
>CP035758.1|QBD76591.1|2504960_2505827_-|EamA-family-transporter
MGHLALGLVLISACLHASWNYLAKRAGNSAAFVWLFSALSALIYLPLLIALILLGQAHLRGLQYVFVLGTAILHVAYFLLLQRGYRVGDLSLVYPLARGTGPLLSTGAAMLLFGERPTLAALFGIALIISGVAFLVGNPLTLLHAGLRMRPAIGYALLTGIFIASYTLWDKYAVSTLQIPPLLLDASSNILRALILTPFVIGQRNTLRESWQRYSLEALGVAILSPLAYILILFALTMSPVSHVAPLRECSVLIGTLLGARLLSEGHKWQRLGAAGIIMLGSILLALN
>CP035758.1|QBD76592.1|2506167_2506812_-|isochorismatase-family-protein
MTNLEPVTPENSSIILIDYSVGFANLIGSTTVEHNVNSVTALAKVALTFNVPLIVTNGQDTDTPGPIYPALHHLIADHPVVRRGGNFNAFETPEFAAAVEATGRKKLIMAGLMTEGCLLLTALEGLRRGFDVYVVIDACGGETVETHQIAVSRLVQAGAIPVSWFSLAAEYQRSWARQETVEDFLHVVLEHSPAFALNLAHHTAAQQSGHRVQA
>CP035758.1|QBD76593.1|2506992_2507589_+|TetR/AcrR-family-transcriptional-regulator
MNKQVSSPNRQARRTRQLLHDALKRLLQEKSFHALTVNDLAEQAGLNRGTFYLHFTDKYALLDDYIREEFQHVLLARLSPSASLSRETLHLLALTTLEYLAQTYERCRSSDKPVESLLERAVQQEVYHTVLKWLTQDQKPATSSLVSAETMAMVVSWSIFGAGIQRRQGHREISSEALAQQITTALLNALSSRILVLE
>CP035758.1|QBD76594.1|2508225_2509572_+|MFS-transporter
MGANHMAQKPDSSDLYTDDLAASVHAEVPSRERRPDPPLWRNRDYMLLWSGQMISSIGTQVSQITLPLLVLALTFSPVQAGLVGALRGLPFAIFSLPAGALVDRWDRRKVMLLCDTGRALALGSIAVALWLGCLSLLQLCLVALIEGTLFTFFYPADVACLPRVVSREQLPAATAQNFASDSLSSLLGPFLGGMLYGIGHAVPFLCDAFSYVCSVIGLFFMRTKFQQERTQVSSPIWREVMEGLTWLWQNPLLRLLALLYCGLSTPIYGYALAWITLAQRLHATPFVIGALFACSGIGSIAGALLAPAVQKRLPFGRLIVCSAWIWAIGWLIYAYVPNLLIFGVIVSLAFINVSIFNATQFSYRLIVTPDHLQGRVNSIFRLIAFGGQPLGLLVTGWLIQWTGPNWAVIILFVPQGLVALMAALSPTLRGTPFLSQLGQKKIEDAHWE

Crispr_ID: CP035758_16

• CRISPR_ID: CP035758_16
• CRISPR_location: 2535981-2536230
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of CP035758_16

Consensus_repeat	Method
CTCGAAAAGAAGGGAAGCCCGTTAGAGG	CRISPRCasFinder
GAAAAGAAGGGAAGCCCGTTAGAGG	CRT

spacers of CP035758_16

>16.1|2536009|45|CP035758|CRISPRCasFinder
GATTGGAACATGTAAATTGAGCAACGTGGCAACTTCATACTCGCC
>16.2|2536082|45|CP035758|CRISPRCasFinder
AATTGGAAGTTGTTCAATCAGTTTGTCCAGGCTATTGGCCGACTG
>16.3|2536155|48|CP035758|CRISPRCasFinder
AATTGGAAGCTCAAGAGGATAATACTCGTAGAAGCCTGATTGATTAAG
>16.4|2536009|48|CP035758|CRT
GATTGGAACATGTAAATTGAGCAACGTGGCAACTTCATACTCGCCCTC
>16.5|2536082|48|CP035758|CRT
AATTGGAAGTTGTTCAATCAGTTTGTCCAGGCTATTGGCCGACTGCCT
>16.6|2536155|51|CP035758|CRT
AATTGGAAGCTCAAGAGGATAATACTCGTAGAAGCCTGATTGATTAAGCCT

CRISPR arrays and Neighbor proteins around CP035758_16

CRISPR arrays

The CRISPR arrays of CP035758_16

>merge|CP035758|16|2535981-2536230|CRISPRCasFinder,CRT
CTCGAAAAGAAGGGAAGCCCGTTAGAGGGATTGGAACATGTAAATTGAGCAACGTGGCAACTTCATACTCGCCCTCGAAAAGAAGGGAAGCTCGTTAGAGGAATTGGAAGTTGTTCAATCAGTTTGTCCAGGCTATTGGCCGACTGCCTGAAAAGAAGGGAAGCCCGTTAGAGGAATTGGAAGCTCAAGAGGATAATACTCGTAGAAGCCTGATTGATTAAGCCTGAAAAGAAGGGAAGCCCGTTAGAGG

>CP035758|16|14|2535981-2536230|CRISPRCasFinder
CTCGAAAAGAAGGGAAGCCCGTTAGAGG	GATTGGAACATGTAAATTGAGCAACGTGGCAACTTCATACTCGCC
CTCGAAAAGAAGGGAAGCTCGTTAGAGG	AATTGGAAGTTGTTCAATCAGTTTGTCCAGGCTATTGGCCGACTG
CCTGAAAAGAAGGGAAGCCCGTTAGAGG	AATTGGAAGCTCAAGAGGATAATACTCGTAGAAGCCTGATTGATTAAG
CCTGAAAAGAAGGGAAGCCCGTTAGAGG

>CP035758|16|6|2535984-2536230|CRT
GAAAAGAAGGGAAGCCCGTTAGAGG	GATTGGAACATGTAAATTGAGCAACGTGGCAACTTCATACTCGCCCTC
GAAAAGAAGGGAAGCTCGTTAGAGG	AATTGGAAGTTGTTCAATCAGTTTGTCCAGGCTATTGGCCGACTGCCT
GAAAAGAAGGGAAGCCCGTTAGAGG	AATTGGAAGCTCAAGAGGATAATACTCGTAGAAGCCTGATTGATTAAGCCT
GAAAAGAAGGGAAGCCCGTTAGAGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD76608.1|2531377_2531791_-|DUF3224-domain-containing-protein	unknown	unknown	gnl|CDD|371584
CP035758.1|QBD76617.1|2543239_2543806_-|TetR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
CP035758.1|QBD76621.1|2546869_2547532_-|trimeric-intracellular-cation-channel-family-protein	unknown	unknown	gnl|CDD|225415
CP035758.1|QBD76607.1|2530574_2531237_+|HxlR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|334619
CP035758.1|QBD76616.1|2542718_2543237_-|DUF4440-domain-containing-protein	unknown	unknown	gnl|CDD|379209
CP035758.1|QBD76613.1|2538294_2541099_+|hypothetical-protein	unknown	unknown	gnl|CDD|238121
CP035758.1|QBD76604.1|2527708_2528491_-|DUF1211-domain-containing-protein	unknown	unknown	gnl|CDD|377696
CP035758.1|QBD76615.1|2542272_2542677_-|tautomerase-family-protein	unknown	unknown	gnl|CDD|379645
CP035758.1|QBD83442.1|2529568_2529964_-|hypothetical-protein	unknown	unknown	gnl|CDD|259988
CP035758.1|QBD76618.1|2544113_2544920_+|N-acetyltransferase	unknown	unknown	gnl|CDD|379228
CP035758.1|QBD76610.1|2532993_2533959_-|NADP-dependent-oxidoreductase	unknown	unknown	gnl|CDD|176191
CP035758.1|QBD76609.1|2532101_2532953_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
CP035758.1|QBD76612.1|2536891_2537917_+|IMP-dehydrogenase	unknown	unknown	gnl|CDD|176247
CP035758.1|QBD76620.1|2546042_2546594_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|173926
CP035758.1|QBD76603.1|2526425_2527670_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
CP035758.1|QBD76611.1|2535069_2535654_-|Crp/Fnr-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223736
CP035758.1|QBD76619.1|2545201_2545927_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|379312
CP035758.1|QBD76606.1|2529978_2530392_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76614.1|2541212_2542058_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD76605.1|2528588_2529386_-|hypothetical-protein	unknown	unknown	gnl|CDD|238204

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD76608.1|2531377_2531791_-|DUF3224-domain-containing-protein	gnl|CDD|371584	pfam11528, DUF3224, Protein of unknown function (DUF3224). This bacterial family of proteins has no known function.	3.21565e-28
CP035758.1|QBD76617.1|2543239_2543806_-|TetR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.68959e-12
CP035758.1|QBD76607.1|2530574_2531237_+|HxlR-family-transcriptional-regulator	gnl|CDD|334619	pfam01638, HxlR, HxlR-like helix-turn-helix. HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.	2.02907e-30
CP035758.1|QBD76616.1|2542718_2543237_-|DUF4440-domain-containing-protein	gnl|CDD|379209	pfam13474, SnoaL_3, SnoaL-like domain. This family contains a large number of proteins that share the SnoaL fold.	0.00104435
CP035758.1|QBD76613.1|2538294_2541099_+|hypothetical-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	6.41946e-87
CP035758.1|QBD76604.1|2527708_2528491_-|DUF1211-domain-containing-protein	gnl|CDD|377696	pfam06736, DUF1211, Protein of unknown function (DUF1211). This family represents a conserved region within a number of hypothetical proteins of unknown function found in eukaryotes, bacteria and archaea. These may possibly be integral membrane proteins.	1.60672e-23
CP035758.1|QBD76615.1|2542272_2542677_-|tautomerase-family-protein	gnl|CDD|379645	pfam14552, Tautomerase_2, Tautomerase enzyme.	6.54042e-41
CP035758.1|QBD83442.1|2529568_2529964_-|hypothetical-protein	gnl|CDD|259988	cd13921, Amicyanin, Amicyanin is a type I blue copper protein that plays an essential role in electron transfer. In Paracoccus denitrificans bacteria, amicyanin acts as an intermediary of a three-member redox complex along with methylamine dehydrogenase (MADH) and cytochrome c-551i. The electron is transferred from the active site of MADH via the amicyanin copper ion to the cytochrome heme iron. The electron transfer from MADH to cytochrome c-551i does not involve a ternary complex but occurs via a ping-pong mechanism in which amicyanin uses the same interface for the reactions with MADH and cytochrome c-551i.	1.13815e-10
CP035758.1|QBD76618.1|2544113_2544920_+|N-acetyltransferase	gnl|CDD|379228	pfam13508, Acetyltransf_7, Acetyltransferase (GNAT) domain. This domain catalyzes N-acetyltransferase reactions.	2.04746e-09
CP035758.1|QBD76610.1|2532993_2533959_-|NADP-dependent-oxidoreductase	gnl|CDD|176191	cd05289, MDR_like_2, alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases. Members identified as zinc-dependent alcohol dehydrogenases and quinone oxidoreductase. QOR catalyzes the conversion of a quinone + NAD(P)H to a hydroquinone + NAD(P)+. Quinones are cyclic diones derived from aromatic compounds. Membrane bound QOR actin the respiratory chains of bacteria and mitochondria, while soluble QOR acts to protect from toxic quinones (e.g. DT-diaphorase) or as a soluble eye-lens protein in some vertebrates (e.g. zeta-crystalin). QOR reduces quinones through a semi-quinone intermediate via a NAD(P)H-dependent single electron transfer. QOR is a member of the medium chain dehydrogenase/reductase family, but lacks the zinc-binding sites of the prototypical alcohol dehydrogenases of this group. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	3.82516e-89
CP035758.1|QBD76609.1|2532101_2532953_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	4.06088e-28
CP035758.1|QBD76612.1|2536891_2537917_+|IMP-dehydrogenase	gnl|CDD|176247	cd08287, FDH_like_ADH3, formaldehyde dehydrogenase (FDH)-like. This group contains proteins identified as alcohol dehydrogenases and glutathione-dependant formaldehyde dehydrogenases (FDH) of the zinc-dependent/medium chain alcohol dehydrogenase family. The MDR family uses NAD(H) as a cofactor in the interconversion of alcohols and aldehydes, or ketones. FDH converts formaldehyde and NAD to formate and NADH. The initial step in this process the spontaneous formation of a S-(hydroxymethyl)glutathione adduct from formaldehyde and glutathione, followed by FDH-mediated oxidation (and detoxification) of the adduct to S-formylglutathione. The medium chain alcohol dehydrogenase family (MDR) has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The N-terminal region typically has an all-beta catalytic domain. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit.	0
CP035758.1|QBD76603.1|2526425_2527670_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.16779e-48
CP035758.1|QBD76611.1|2535069_2535654_-|Crp/Fnr-family-transcriptional-regulator	gnl|CDD|223736	COG0664, Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms].	1.74493e-17
CP035758.1|QBD76619.1|2545201_2545927_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	1.004e-23
CP035758.1|QBD76620.1|2546042_2546594_-|GNAT-family-N-acetyltransferase	gnl|CDD|173926	cd04301, NAT_SF, N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate. NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.	0.00829219
CP035758.1|QBD76621.1|2546869_2547532_-|trimeric-intracellular-cation-channel-family-protein	gnl|CDD|225415	COG2860, COG2860, Predicted membrane protein [Function unknown].	3.33781e-56
CP035758.1|QBD76605.1|2528588_2529386_-|hypothetical-protein	gnl|CDD|238204	cd00333, MIP, Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.	2.39417e-50

Protein sequences

>CP035758.1|QBD76611.1|2535069_2535654_-|Crp/Fnr-family-transcriptional-regulator
MSAYEQFASFLRAWTAVPDRELAKAAEIFQPAAVPRGTIFLHAGEIPQTISFIVSGLARLYYIEPSGLERTKAFRLENQFVCAYSALLRGEPSRLFIQMLEPSSLLIAPYQAYQRLAAGHVCWQQVSLKIAEWLYVEQEQRQSELLLDDATTRYLKFLAEYPGLTTRVKQLHIASYLGITPVSLSRIRAQLSNS
>CP035758.1|QBD76610.1|2532993_2533959_-|NADP-dependent-oxidoreductase
MSHGMMRVAAIERFGDPEQLSIQKVPLPDPGPGQVRMRIAAAAVNPADLGMVTGVYRWKEEVSFPLVPGYDAAGSVDALGEGVSSFQVGDQVIACSQHSLTQVGTYAEYAILSEHYLAPAPQGIELIAAASLPLAGLTALQALEQLQLAPGQTLLINGPLGAVGGFALQLVALRGIQVLAPTFAHEAELARTLGATFMLDREQDIPAQVKQAVPSGVDAALDVIGGVAARSAFEAVHDGGLYVTVVPEFWVPGGQFVPQRGITPRVVGVRSNTLQLIELSSLLANGQLTTRVAKVFSLEHASTAHRLLAAGSIHGKIILLP
>CP035758.1|QBD76609.1|2532101_2532953_+|class-I-SAM-dependent-methyltransferase
MPQQTPQESSYPVEVENIAEMARLTRQARVFTGATNLLPDDIHLSAGQALDIGCGPGEWVLALAEQYPDLNVVGIDVSEVMTRYAQALAVEKELSHVRFRVMDVCKGLAFPEASFDLLHIRTAIAFLTPALWSAFLRECYRVLKPGGILLGVEGDDGGSNSPSLTRLMVLMMQALRKVGHCFTSEGTNSGIVSMYPRLLREAGLSVIRREAFLLDYSYGTPAHGEMTQDLAIAFRLATSFFSHLTNESEEEIEILRQRALEEIQAPDFCASFFIQRISAMKPA
>CP035758.1|QBD76608.1|2531377_2531791_-|DUF3224-domain-containing-protein
MIQANTTRKVKGWQRKTWHHKTEVPGTNLFRIEMIHHYEGALEGEGSIQYLIAQNKNLTGSVIALEKVTGSIAGRAGSFVFQQIGTFEHGRLKLNLTVVPGSGTDQLSGLRGQAKLESELHQEVYLLPFEYTFEESE
>CP035758.1|QBD76607.1|2530574_2531237_+|HxlR-family-transcriptional-regulator
MSRVKKTTVCPLGGVGIGGKWMFWIWYHLLSGTKRFGELQRLVPEASRQMLTLELRQLEQVGVLRRQVYVQVPPKVEYSLTEVGRKAEPIVRQLAAWGQWYGGQVNLEFDWMISLGGRWKFWIWYHLLSGSKRFNELQKLLPKISRQMLALELRELERMKVLSRQAPAHGSLRAEYELTELGRNSGPVLRQLYAWGRWICEELDLEFDWPVLDEAEVRAS
>CP035758.1|QBD76606.1|2529978_2530392_-|hypothetical-protein
MKTIVNILHWIGGLAGLGVLALGLFIWISGMSPITLQIVHALLGLTFVLALLILGIIAVISRETRLQGIMCIVYAPLVPIFGMLQMTLLVGDLHWLIRGAHLLIGLAAFILFGTTGMRYLRVKEPVHKVGKQPQLIR
>CP035758.1|QBD83442.1|2529568_2529964_-|hypothetical-protein
MMAKLFSRLALGFLLVTILTACMAAGTSTQTTAGTEVHMDSSRFSQTEITIQKGQSVTLINDDPLTPHVIANGTWENGTAKPGIEPNTPKVKDLQINGSARATLGPFNASGTFRFYCTIHPGMSLTVIVRR
>CP035758.1|QBD76605.1|2528588_2529386_-|hypothetical-protein
MMSQEQQSPDDEQAKTHDQPEDSREAEAQKLSSAQRMREELRRLLAEVIGTFMLVIVEAGGIVVADLFHQDINSAAHYASCGLIVMAIIYALGSVSGAHINPAITFAFALRKDFPWKRVPGYWIAQLIGALAAAALIRLLFGNVRQLGATIPHMEAMHVFAVEALLTFILVTVVLGVAPKGELVGNNMAISVGGTIALCGLFAGHISGASMNPARSFGPYLVSGQLGEVWIYILAPFVGALIAAGLAWLLRGRTTSKAVEAAKGK
>CP035758.1|QBD76604.1|2527708_2528491_-|DUF1211-domain-containing-protein
MSRPIRPPLESLFGKPVQEEHSPGEDRLVMLCDGVFAIAITLLVLDIKLPPIPAHIADPAGFVHNNIMGLLPKIVIYLITFFLLAQLWQDHRTMMRYIQRLDKVFISLTFLFLAFIVFFPVAFNIAAEYSDFPEGVVFYTLSLIGCGCSAQLLWLYASWRHRLTGPETNSTLIASRSIHSLIVPVYFCLSLLLLLIPSFHDQPSKVYWSWIFLPIFAVFIGRILHRFFPALEVPPADKAQNLPSEESNKDDEKYQKIEQQ
>CP035758.1|QBD76603.1|2526425_2527670_+|sensor-histidine-kinase
MEVVPSPTQVITYTLCRWYTKEVLPSREGDSQLMFRFYARESEPVMLKPFSPRPSRSSKRPFFPFPGFASLQMRLGCAYMWTNMLLVVVFLVLVVVVNWLAFWLPHHSPAGQILWWASIFLPGAALLLGVALPIFALIGGLFGLWTSRKLVLRLRQLAHATRIIANGDYYTLRVPVQRKDEVGVLEEQFNRMAQQLAESQQREQELLAQNVRWEERARLARELHDAISQNLFSLRLLAEGMQTSQLEPAVFKEKLALVGRTAETITREMRVLLLELRPVQLEDLGLKEALEELAVMYHARLDLAIVTDIAELALPDQMEHALFRIAQEAISNAVRHAQASWISLKLAARQEQVMLCVEDNGKGFKPLMQESYYGLGLQSMQERVRELKGTLQIQSMPMQGTSISVYLSYKGKNE
>CP035758.1|QBD76612.1|2536891_2537917_+|IMP-dehydrogenase
MQGTLLYGPRDVRFEERADPKISEPTDAIIKIVATCVCGSDLWPYRGIEELSQPQPMGHEYVGIVEDVGSAVKNIKVGDFVIGSFAISDNTCEICKAGYQSRCVHGQFVSQTIGTQAELARIPLADGTLVATPGRPDRDLIPSLLAASDVLGTGWFAADAASVGPGKTVVVIGDGAVGLLAVLASRQLGAERIIAMSRQAKRQELAREYGATNILTERGEAGVEKVKELTSGLGAHSVIEAVGTQESMLQAIRSTRPGGFIGYVGVSHNVKLDGEELFFSEVHLHGGPAPVRRFLPDLIERIWKRQINPGKVFDLQLPLAQVAEGYRAMDERRAIKVLLWP
>CP035758.1|QBD76613.1|2538294_2541099_+|hypothetical-protein
MQTRIGQYLGNYRLTHFLGRGGFAEVYLGEHRRLQSQAAIKILSTQLAGNDEAKFLAEARTLAHLDHGHIIRILDFDVQEGTPFLVMYYAPNGSLRQRHPRGSRLALSTVVEYVQQIAQALQYAHERQIIHCDVKPENILVGRHNELLLSDFGISLVAQEAQAIGIHKGLGTPLYMPPEQFQGQPHLVSDQYALAIMIYEWLTGACPFAGTFPELYGQHLSVLPPSLHERVPSLPAMVDQVLKVALAKDPHRRFKSVGAFARAFEYASRNPQTSSLLPHSSSEWRILGEQQAPSADASEHTIRAKGHQSGIRRRMTKPIPAVGKEASAGKQSSAAKSARPSLATVRPALLYTYKGANLAETYVVAWSPDGRHIASSDSAGEVQIWDAHNGQVVYTYRGHRDAVYALSWSPDGKRIASGGDDQTVQVWDALDGGNIYIYRGHTDVVYAISWSLDGTRIASGGKDMTVQVWDATNGNNVSNYKDHTDMIYALSWSPDGKRIASGGKDKTVQILDAMNGNAVQVYQGHAEPVHALSWSLDGTRIASGGRDRTVQILDVEGGSNIYNYKGHEDIVFTVSWSPDGTKIASGGGDRTVQIWDATNGENLCTYQGHRKSVYTVSWSPDGTRIVSVSRDIKGAVWDVVSGRTIQLFKEPINPIYAVSWSPGGTRIAAGGEDATVQVWDAANGKNLCIYKGHSKIALALSWSPDETKIASASVDGTVQVWNALNGKKLYSYQGHSKSVYAVSWSPDGQRIASGSFDGTVQVWDALDGANMSIYKGHSKAVYAVSWAPDGKQIASGSIDGTVQVWNALDGRSLHVYKGHGSAVYTVSWSPDGTKIASGSADGTAQIWTVAGKGKVITYGGHNKTVLAVKWSVDGSHIASGGFDGTVQVWDTTNGRDHYTYRGHSNAVYAVGWSPDGTKIASGSVDGSVQVWQIF
>CP035758.1|QBD76614.1|2541212_2542058_-|hypothetical-protein
MSMLLLKLIAAPLLIGIASVAGRRWGPAVSGWLVGLPFTSGPVIFFLALDHGRAFGTAAAIGTLTGTISQAAFSLTYAWLAFTGRWPLALGGSCLAFLLATFALQYFTLPVLPLYLLILVVIVATLLLLPRTSSALVARAPARWDIPLRMLIATVFVLALTTLAPLLGPQLSGLLTPFPLYATILSVFAHSTQGPGASANVLRGLQFGLFAFITFFLVLALLIQQGSLGLAFLIATACALIVQACMLVVFRRLTRAQAVKPALLNEPHDQQSGSHTHPLTR
>CP035758.1|QBD76615.1|2542272_2542677_-|tautomerase-family-protein
MPLVHINLRQGKSTSYIRSICEAVQQALVECLDVPVRDKFQIVHEHSAEHLIYNPHYLDIDRSDDIAIIQVTLSKGRSTAQKQAFYARLATLLQEKPGMRPQDIMIGLVENTREDWSFGFGEAQYLTLPREQWK
>CP035758.1|QBD76616.1|2542718_2543237_-|DUF4440-domain-containing-protein
MSLEQAYTITYLDETVITGAQNRQTEMQQATFEGALAALETFYHGFNTHSLELLGQNWLDAPLAQLNNPVGGIVRGAKAINNVYARIFAGPVNVQVEFYDIVAYASSGMVVFAGRERGTYGSKDKANPVDIRTTRIFAYNSEQGGWRQVHHHGSIDNAERLAHYVDTVLGAR
>CP035758.1|QBD76617.1|2543239_2543806_-|TetR-family-transcriptional-regulator
MSTREHLVTATMELLWERGYEATSPRAILERSGAGQGSLYHHFKSKADLVATALNEVSNEMQGIVDATLHSNKPPLERVRDYLTQPREALRGCRLGRMIQEPAITQDALLRDPISSYFTYSKRELTAALAQAQQDGTLSPSINVADLATTLIAVVQGGYVMARALQDAEAMEQAIRGALALLEASERR
>CP035758.1|QBD76618.1|2544113_2544920_+|N-acetyltransferase
MKAALQDLSPSKIALAYDANHIAERTLFCQLPKAELHKDPGILWFATGSEIDSFNGVLQTQLEPDSLSSAIERICSYFQWRRLPFLWFVGPSSRPAKLGQSLETHGFIHAETEPIMAIDLLKMNEDIPVSSRLHVQRVATNEQLLQWLRVCFSDCSEEIIQQCLALYSGLPLDLQCPMRLYLGTIDGEPVATSQLFLGLEAVSLGRISTLPQHRGQGIGAAMTLTALREALACGYHMALLAASSLGLPLYQRIGFQECGIFSVYYMAT
>CP035758.1|QBD76619.1|2545201_2545927_+|class-I-SAM-dependent-methyltransferase
MSHTSYNDIAGWYDQYIRESPLYRGVFLPQFWDLLGDVEGQTVCDLACGQGWIARELARRGAHVTGIDLAENLLALAKRAEEQKPLGIVYLQGDAQNPQAFIKGSFDGLVCVLSLMDIADLQAVFQTMQRMLKPGGWLVFAITHPCFQAPHAQWITTDSGEVARVVRGYFKEGFWMTATPGGVRSRVGAHHRMLSTYLNALVAANFTLEQMLEPMATGERARQVPGDCEVPSLLLIRAHLL
>CP035758.1|QBD76620.1|2546042_2546594_-|GNAT-family-N-acetyltransferase
MVFATWWRRDPLPTLSPLPSVSAHLSTDAQLIAQLTNFSLQTITTRFQAGKRLYLAFMSDVPVAYGWVATREGRISDLQLTFALPARNCYLHGFLTLPEWRGRGIYSHFLQSIIRQEPSFDRFWIGYLPNNTASGRGISKAGFHVVSDLVVTGDRACGLTLFESSERALASVDVFHLPVVAAP
>CP035758.1|QBD76621.1|2546869_2547532_-|trimeric-intracellular-cation-channel-family-protein
MHPVVFNPTLEEVLNFVGTFVFAVSGSLLAVRKSYDIVGMAVLAVITAIGGGVIRDLVIGAVPPAAFQDVSYLWIPLLATILTFFAHVEINRLRAAMLIFDAAGLAVFCVSGTAKALNYGLGPGAAIALGTLTAVGGGIMRDVLAHDEPAIFLPHSELYALPAVVGSVIVVFIPRLPLNNSIAAGLTAVFVFVLRLLALRFGWKAPRPWRTTRQEESDES

Crispr_ID: CP035758_17

• CRISPR_ID: CP035758_17
• CRISPR_location: 3781286-3781600
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 4 spacers

Consensus repeat of CP035758_17

Consensus_repeat	Method
GTTAGAATCCCAGGCGGGCTCA	PILER-CR
GTTAGAATCCCAGGCGGGCTCA	CRT

spacers of CP035758_17

>17.1|3781308|51|CP035758|PILER-CR,CRT
GTCTCCCTTTCCGACCTGTCCTGGTGGGTGTGCCTGATGGTATAGGTTGCG
>17.2|3781381|52|CP035758|PILER-CR,CRT
TACTCCCTTTCCGACTACGCCCCAACTATGTCTGAACCTCTTTGTTCAGGCA
>17.3|3781455|51|CP035758|PILER-CR,CRT
GTCTCCCTTTCCGACGGAAGCAATATACAGTACACCGGCAAACTGAGGATG
>17.4|3781528|51|CP035758|PILER-CR,CRT
TACTCCCTTTCCGACGTTGTAACTGTGCTCTGAAGATGCTGGTACTGGTTG

CRISPR arrays and Neighbor proteins around CP035758_17

CRISPR arrays

The CRISPR arrays of CP035758_17

>merge|CP035758|17|3781286-3781600|PILER-CR,CRT
GTTAGAATCCCAGGCGGGCTCAGTCTCCCTTTCCGACCTGTCCTGGTGGGTGTGCCTGATGGTATAGGTTGCGGTTAGAATCCCAGGCGGGCTCATACTCCCTTTCCGACTACGCCCCAACTATGTCTGAACCTCTTTGTTCAGGCAGTTAGAATCCCAGGCGGGCTCAGTCTCCCTTTCCGACGGAAGCAATATACAGTACACCGGCAAACTGAGGATGGTTAGAATCCCAGGCGGGCTCATACTCCCTTTCCGACGTTGTAACTGTGCTCTGAAGATGCTGGTACTGGTTGGTTAGAATCCCAGGCGGGCTCA

>CP035758|17|10|3781286-3781600|PILER-CR
GTTAGAATCCCAGGCGGGCTCA	GTCTCCCTTTCCGACCTGTCCTGGTGGGTGTGCCTGATGGTATAGGTTGCG
GTTAGAATCCCAGGCGGGCTCA	TACTCCCTTTCCGACTACGCCCCAACTATGTCTGAACCTCTTTGTTCAGGCA
GTTAGAATCCCAGGCGGGCTCA	GTCTCCCTTTCCGACGGAAGCAATATACAGTACACCGGCAAACTGAGGATG
GTTAGAATCCCAGGCGGGCTCA	TACTCCCTTTCCGACGTTGTAACTGTGCTCTGAAGATGCTGGTACTGGTTG
GTTAGAATCCCAGGCGGGCTCA

>CP035758|17|7|3781286-3781600|CRT
GTTAGAATCCCAGGCGGGCTCA	GTCTCCCTTTCCGACCTGTCCTGGTGGGTGTGCCTGATGGTATAGGTTGCG
GTTAGAATCCCAGGCGGGCTCA	TACTCCCTTTCCGACTACGCCCCAACTATGTCTGAACCTCTTTGTTCAGGCA
GTTAGAATCCCAGGCGGGCTCA	GTCTCCCTTTCCGACGGAAGCAATATACAGTACACCGGCAAACTGAGGATG
GTTAGAATCCCAGGCGGGCTCA	TACTCCCTTTCCGACGTTGTAACTGTGCTCTGAAGATGCTGGTACTGGTTG
GTTAGAATCCCAGGCGGGCTCA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD77570.1|3787415_3788534_-|FHA-domain-containing-protein	unknown	unknown	gnl|CDD|366133
CP035758.1|QBD77559.1|3776803_3777013_+|hypothetical-protein	unknown	unknown	gnl|CDD|376564
CP035758.1|QBD83496.1|3789701_3790721_+|ADP-ribosylglycohydrolase-family-protein	unknown	unknown	gnl|CDD|224315
CP035758.1|QBD77572.1|3790746_3792219_+|cytosine-permease	unknown	unknown	gnl|CDD|271377
CP035758.1|QBD77560.1|3777301_3777466_+|hypothetical-protein	unknown	unknown	gnl|CDD|376773
CP035758.1|QBD77562.1|3777954_3778239_+|transposase	unknown	unknown	gnl|CDD|377531
CP035758.1|QBD77571.1|3788924_3789647_+|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|225099
CP035758.1|QBD77558.1|3776538_3776778_+|hypothetical-protein	unknown	unknown	gnl|CDD|376564
CP035758.1|QBD77568.1|3785282_3786503_-|glycosyltransferase-family-1-protein	unknown	unknown	gnl|CDD|340842
CP035758.1|QBD77569.1|3786521_3786959_-|divergent-PAP2-family-protein	unknown	unknown	gnl|CDD|376897
CP035758.1|QBD77556.1|3774340_3774883_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD77565.1|3779781_3780642_-|hypothetical-protein	unknown	unknown	gnl|CDD|367446
CP035758.1|QBD77557.1|3774780_3775578_+|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
CP035758.1|QBD77573.1|3792215_3793202_+|sugar-kinase	unknown	unknown	gnl|CDD|238919
CP035758.1|QBD77575.1|3795031_3795403_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
CP035758.1|QBD77561.1|3777482_3777773_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD77564.1|3778713_3779613_+|hypothetical-protein	unknown	unknown	gnl|CDD|372705
CP035758.1|QBD77574.1|3793637_3794867_+|histidinol-phosphate-transaminase	unknown	unknown	gnl|CDD|178597
CP035758.1|QBD77567.1|3783214_3785239_+|hypothetical-protein	unknown	unknown	gnl|CDD|238121
CP035758.1|QBD77563.1|3778327_3778672_+|hypothetical-protein	unknown	unknown	unknown

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD77570.1|3787415_3788534_-|FHA-domain-containing-protein	gnl|CDD|366133	pfam00498, FHA, FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.	7.20752e-21
CP035758.1|QBD77559.1|3776803_3777013_+|hypothetical-protein	gnl|CDD|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	2.77833e-15
CP035758.1|QBD83496.1|3789701_3790721_+|ADP-ribosylglycohydrolase-family-protein	gnl|CDD|224315	COG1397, DraG, ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones].	4.26019e-77
CP035758.1|QBD77572.1|3790746_3792219_+|cytosine-permease	gnl|CDD|271377	cd11484, SLC-NCS1sbd_CobB-like, nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain. This NCS1 subfamily includes Escherichia coli CodB (cytosine permease), and the Saccharomyces cerevisiae transporters: Fcy21p (Purine-cytosine permease), and vitamin B6 transporter Tpn1. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. NCS1s belong to a superfamily which also contains the solute carrier 5 family sodium/glucose transporters (SLC5s), and solute carrier 6 family neurotransmitter transporters (SLC6s).	1.20116e-44
CP035758.1|QBD77560.1|3777301_3777466_+|hypothetical-protein	gnl|CDD|376773	pfam02371, Transposase_20, Transposase IS116/IS110/IS902 family. Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with pfam01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	7.51847e-07
CP035758.1|QBD77562.1|3777954_3778239_+|transposase	gnl|CDD|377531	pfam05598, DUF772, Transposase domain (DUF772). This presumed domain is found at the N-terminus of many proteins found in transposons.	1.49217e-07
CP035758.1|QBD77571.1|3788924_3789647_+|GntR-family-transcriptional-regulator	gnl|CDD|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	2.1773e-46
CP035758.1|QBD77558.1|3776538_3776778_+|hypothetical-protein	gnl|CDD|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	1.51572e-05
CP035758.1|QBD77569.1|3786521_3786959_-|divergent-PAP2-family-protein	gnl|CDD|376897	pfam02681, DUF212, Divergent PAP2 family. This family is related to the pfam01569 family (personal obs: C Yeats).	3.79451e-53
CP035758.1|QBD77574.1|3793637_3794867_+|histidinol-phosphate-transaminase	gnl|CDD|178597	PLN03026, PLN03026, histidinol-phosphate aminotransferase; Provisional.	1.53376e-104
CP035758.1|QBD77565.1|3779781_3780642_-|hypothetical-protein	gnl|CDD|367446	pfam03318, ETX_MTX2, Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2. This family appears to be distantly related to pfam01117.	3.52421e-17
CP035758.1|QBD77557.1|3774780_3775578_+|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	1.16742e-46
CP035758.1|QBD77575.1|3795031_3795403_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	6.8366e-12
CP035758.1|QBD77568.1|3785282_3786503_-|glycosyltransferase-family-1-protein	gnl|CDD|340842	cd03814, GT4-like, glycosyltransferase family 4 proteins. This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.	5.27911e-116
CP035758.1|QBD77564.1|3778713_3779613_+|hypothetical-protein	gnl|CDD|372705	pfam13751, DDE_Tnp_1_6, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	3.3545e-30
CP035758.1|QBD77567.1|3783214_3785239_+|hypothetical-protein	gnl|CDD|238121	cd00200, WD40, WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.	3.29835e-100
CP035758.1|QBD77573.1|3792215_3793202_+|sugar-kinase	gnl|CDD|238919	cd01944, YegV_kinase_like, YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time.	4.3811e-77

Protein sequences

>CP035758.1|QBD77565.1|3779781_3780642_-|hypothetical-protein
MFQRGCAKREKETAVTTSVDVDKHIGESIATLVRESSPLITHAQVHELQYGELRFAGDISYAQQWTPGTTFDTIDEIEENNRTPNPQTAHIERNETVMNSYTWATEEAISLGMSVSASFKVPFVGGIDTSISTDYSFTSTETVTETKERGWKFIQDVLVPPHSKLTAVLKIEKTIPRVPFEMTGAFTGHMITDVSIWMGPLQSMLHAVRYPITTIFERRPLPNARVEGNTVYLTLKGVFTAAEGMKAIIDLTEVPLGGLDQAPKHWIVDVTPEHEIHVPQLPAEAK
>CP035758.1|QBD77564.1|3778713_3779613_+|hypothetical-protein
MMSGLRASSAFAAMRIFLQVSSSSTPLMIKKPAMVKSVKRDGLVTSVHLTETCEDDAPHLIAHVTTSAAATTDEAMTETIHAELEQKKLTPRQHLLDSGYITAPILVSSHQQYGIEVIGPARGDVKWQANTEGGIDASQFHIDWEQKLAICPAGQRSINWTPAIDDRKNEVIKIKFSTTDCSHCPRQVGCIRSEKKSKRRTITVRPQAQHEALQAARRRQKTSAFARQYVLREGVEATMSQGVRAFGMRRSRYIGLAKTHLQHLGIAAAINLVRVGAWLGGEDLTPTRFSAFQRLCFEA
>CP035758.1|QBD77563.1|3778327_3778672_+|hypothetical-protein
MPCWSYLKSGVGGSERQRQRTDSTHVLARVRAIHRLMCVGEAMRFALNSLAIIAGDWLLAHSDPQWVDRYGHRIEEPRLPRNQQDRQAIAEQIGPDGSQLLADLYAREAPAFFT
>CP035758.1|QBD77562.1|3777954_3778239_+|transposase
MTFHSQNEFSIPEETARVACAAYPKGNLYMQMHIALGTIYQDEAFAHFFPQNGRPAEAPWRLAFITVVQFLEGLPDRQAADAVRGRIDLKYALG
>CP035758.1|QBD77561.1|3777482_3777773_+|hypothetical-protein
MRATLVQAAHGARRSKTYLGERYRRLKKRRGSKRAALAVGHNILVIYSQMMKTGEPYREKGEAFFHQTNLDQVEHRLIHRLEQLGYQVSRQPQPAA
>CP035758.1|QBD77560.1|3777301_3777466_+|hypothetical-protein
MKRLTGVSREGIHVLMAEVGTNLERFPDAEHLSSWAGVCPGKTGKRRQTTQRKS
>CP035758.1|QBD77559.1|3776803_3777013_+|hypothetical-protein
MKAVPGRKTDVQDAEWIADVLQHGLLTASFVPSQHQQELRDLTRLRVSLVQERGRLINRVRHPSLKRQA
>CP035758.1|QBD77558.1|3776538_3776778_+|hypothetical-protein
MQVMYERCAGIDVHQRFLVVCLSSVEAGELRKEIRSFRDETSDLLALREWLVQVKGTHVGMESTGVYWMQVYRRQDRLL
>CP035758.1|QBD77557.1|3774780_3775578_+|ABC-transporter-ATP-binding-protein
MYQQDRQIVVPRSLVGFGWGGLSTLANAAISIYIALQAISRAITIGSLNMYAQAVMQVGSSFQGMLADISGIYENNLYVDTLYEFLEYQPRILSPADPRSIERDPVVPGLSIEFRDVSFTYPDKDPETETALHHVSFTIKAGEAIALVGRNGAGKTTLVKLLTRLYDPDEGQILIGGRDMRDYSIEELRHVVGVIFQDYVTYFLTARENIGVGKVEEIDNLDLVERAAGKSGANAVITNLPSGYETLKQEARVAELEAKLAGLEP
>CP035758.1|QBD77556.1|3774340_3774883_+|hypothetical-protein
MQERLGNRVQSMILHKVETLDLTFFENADFYDELRNASDESIYKPMQMISQVFDVLKTVMTLFSRLALLLSLAWWLAMSALLMPIPSFLSSSRYGWHSYQKMCRQSPQRRRLHYLVRLMTTDTYNKEIKLFNLGPFFSTSMTRWPRSCINRTGKLWCRVPWSVLAGAASLPWPMQPSPST
>CP035758.1|QBD77567.1|3783214_3785239_+|hypothetical-protein
MGDRTGQQLNNYRLLHLLGTSNSAEVYLAEHISMGTQAALKILRRPLSEQKQQDLRQEVWALSQLKHPHILRMIGAGSSEDEHIPFLVMEYAPGGSLREHYPPDKIMPLASLIPYTRQIAEALQYAHSEGFIHRNVRPQNILFAENGTLQVSDFAITATSQMLPLQHEAYYMAPEHIQGHAYPESDQYALACCVYQWLTGHLPFTGTHIAEIISHQLYDSPRPPRIYVPDISPAIEEAVLTAMSKDEGERFGSVLAFALALEEAANLPAPIKPTVYILSGPQSTRTEQGASLAPLALASSETVSPNQSSSGAATPTEPQDAKPTQRTTDEVSSHSHGTNTLKKPAVPISRRAILIGLAGLTISGGLALWQLPQASHIISPNADLIFTYQGHKSHVNSVAWSSDSKRIASAGDDFTVQVWDATDGNNPYTYTGHTDDVFAVSWAAKGKLIASAGRDHTVQIWNSSNGTLLRIYRGHKAQVNTVTWSPNGSLIASGSSDHTVQIWNPATGKLLYTYKGHGDSVNAVAWSPNGQHIASAGLDKTIQVWHPVDGSLLYIYRGHSASVNSIAWAPNSKRIASASNDSTVQVWDATAGTHVLTYKGHTNLVWTVTWSPEGSYIASGGWDETVQVWNANTGAHRYTYGDHTNIIHAVAWSPDNQFIASASLDHTVQVWSSP
>CP035758.1|QBD77568.1|3785282_3786503_-|glycosyltransferase-family-1-protein
MRIAFFSETFLPQTNGIVTRLCHTLSELKARYADRVLLVAPEMPGLPTHYDGISVLGVPSVDLPFYRGFRFGLPWLHTRAGAALEQFAPEIIHAVNPASGIGLLALHYAARYRVPLVASFNTDLPGYVRHYGLSVLEEPLWQYLRWIHSQAALNLCPSRPVQERLNARGIHNVALWRSGVDTALFHPQHFSCGWREKLTNGDPDVTIILSVGRLAAEKGLDKLISTLPQLAGCHLAIVGDGPAAEQLRQQANGLPITFLGTLQGEDLATAYASADIFAQPSTTETFGFVTLEAMASGLPVVAARRGGSLDLVLEGETGLLFEPDQPQALERAVRYLAEHRRERKQMGNAARLYIEGSEWSWRTATAELHRSYEQVLAKAKTGSSDEALPPLQHDADSQKHSLPFAR
>CP035758.1|QBD77569.1|3786521_3786959_-|divergent-PAP2-family-protein
MDALLNNRVLIASFLAWAIAQIVKTIYAALSQHKLMLSSLVSSGGMPSAHSALVACMATAAGRLDGISSPAFAVAVVLAGIVMYDAAGVRRAVSVQARLLNQILDKLFQGQILSQQKLYELVGHTPIQVFAGGLLGILVGLVMTR
>CP035758.1|QBD77570.1|3787415_3788534_-|FHA-domain-containing-protein
MEAFLNGPMGRIPLGASLLTLGRSPDNQVVVSDRQASGHHAELRLEGQAYYIVDRGSTNGTFLNEQRLGSNMPRMLMSGDNIRIGSTILTYESVGGSVERTVLAPPGQDVANANVSTYPASYNMGQSGSGFPPQQPPFQVQPPQQPQAPFQGQPQPFQAYQRSGVNYPQQGYPGQPAGYPAQPPQPGHQPQLPPLPQYPGGSNNLQSKRNGLLGPLILVLVLIVIVGAGYLVIVKGASNQNSKKQASTTAVAATPSPMPSPTPAKPKETVQQVMTNYCTYVKREDTHSMYNQLSKRQKSQTTEQQFTQDLKQKEALTGPPTGCQVSNVRENGSTATADATLTFAAYPQPVVTHVTLVKEDSDWKVDNAKTDQ
>CP035758.1|QBD77571.1|3788924_3789647_+|GntR-family-transcriptional-regulator
MSRQDSAYLRICNAIEYDIRAGKFRHGHRLPGEHWLAQHFGVSRMTIRQALSELARKQLITTRAGSGSYITFDNQHLEWTQGWSRAMTLHGARVEARVLHFGPLDDPELAARFQIKSRFIALDRLRLLDGTRAISLERSRIPLNAETEALLDIDFAHESLMDALSNRAGLFPASSEEWIEVARLRTEEAHLLERAIGEAFLLSRRVTRDQKGALIEHVSSLLDPSHFRLHINFDLNERQK
>CP035758.1|QBD83496.1|3789701_3790721_+|ADP-ribosylglycohydrolase-family-protein
MDAMRQRALGALAGLAIGDALGMPTQLLPRQKILQLFPTLDNFADGPPENEISAGQLAGSVTDDTQQALIIARLLIAGNGHIDTSQFIAQLLAWSREAEANGSEQLGPSSRRALEAIQQGLPIEQAGRRGDTNGAAMRIAPVGIAVPPAPLEALIDLVEDVCRPTHFTGLGIAGAAAVAAAISAGVSGATFSEALPIARQAARLGQQRGNYSPGASIGERLVWAVDLVSQLDESSALDAIYDLIGTGVAMQEAVPAAFALASLWPDDPWQACLAAAHLGGDSDTIGAITGAILGACCGIEAFPPQAISTIERVNKLDLHALSTPLLAVRATISTAPSTS
>CP035758.1|QBD77572.1|3790746_3792219_+|cytosine-permease
MNEQQQPPQSDKVWSIELHGIEPIADNERHGTAFELFWVWFAANIGILGIVYGGILATSGLNLWQSILVALIAPAASFALVGVLSIAGKWGGAPTLTLSRAPFGTRGNLGPTLISWISLVGWETISVITAAYALLGLLNLVGLPSNVFWTIVSLIIIAVLVVVIGLLGHATLVWIQQAATWIFGALTLVVVVFLLARTNWSAVLAAQPGPWDTGVLATLSIIIAGTGIGWANAGADYARYLPHKVKGSSIVGWTVFGSTLPLFVLILTGRLLASHLSNLASAENPVLAIGSALPSWMAIPYLITAIGGLVAGADLSIYSSGLNLLAIGLKIERYKTVIIDGVLMIAGAIYVMLIAQNFFTPFESFLQLLADGLTAWSAIFLIDMLKRRSYNIAGLTDTSARSSYFYIAGINRAALIAWLLGILAGLAFTVSPWFSGPFAIGIFATSSLGYLIGFLVSALIYWLLFVWGAKGQSSADQQSSSYELPREVTL
>CP035758.1|QBD77573.1|3792215_3793202_+|sugar-kinase
MKSAARRQPQRLVLIGSVLIDILMYVDHLPERGGDSVARRTMLTSGGGFNLLAGARRLGLSAAYAGRVGDGPMGNQVIADLEAAGIPLLLPRVRGEDSGFDIALVEQDAERTFVTAPGIESRLRLEDLRQLFLQPGDAVYVSGYELCYPISGASLESWLPGLSEQVLLVFDPGPLVAEIPATRLEHLLTRVDIISLNAREAHILTGTTKLDDATASLVPRIASRGLVIARAGAEGCWIASSTHAPQHIPPRPTRAVDTTGAGDTHVAALLARLAAGDDFASAAYQANVAASISVERPGPATGPTLQELASTLEAMHGSSLPIFSSQPH
>CP035758.1|QBD77574.1|3793637_3794867_+|histidinol-phosphate-transaminase
MLEKSPSVRILQAPNDEFHIPVRPEIARLAPYIPGESSQEFSKRTGFPLEALLKLNCNESPYGPVAAFQRQLQNYTFYQQYPDTQSYQLKTALAAYTGVHEHAIVLGHGSMELITLLWSLFLSPGDEIISCPPTFSLYATAAALCGAQLVSVRRRADYEIDTRAILASLNPSTKMIVVCSPNNPTGNLLAQEDLLTLLDTGRIVVVDEAYIEFSTRPAGYAHLVGRYENLVVLRSFSKWAGLAGLRIGYGLFPEWIASYLRRMQNPFEVNVLGHIAVIETLAHLEEAMEKVQRVIEERGRLYRMLAQQPFLDPIPSQGNFVLARILTEQVALPQIRKAVEADGILLRYFPNLLDGQDFLRVTVGLPEHTARLRSALAHVGLPSAECLTSNSLHWRFLEEFLCDLNSWAT
>CP035758.1|QBD77575.1|3795031_3795403_-|CPBP-family-intramembrane-metalloprotease
MMGKHMGAKKLLNTFISPGIEEEIAFRGVLMTRLIRAFGTSWGIVVASLIFGVYHVFTNITLLHLPVAVAVMQTITFQAVFGVTLAFVLLRTRNIVASILYHGVLDALNFTVLSIVLPLLLLH

Crispr_ID: CP035758_18

• CRISPR_ID: CP035758_18
• CRISPR_location: 4005919-4006008
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP035758_18

Consensus_repeat	Method
TCGTATTACGATATATTTATTATAAATTTTG	CRISPRCasFinder

spacers of CP035758_18

>18.1|4005950|28|CP035758|CRISPRCasFinder
TTAGTTTTGCTCTTGCTTGCCAGTTATA

CRISPR arrays and Neighbor proteins around CP035758_18

CRISPR arrays

The CRISPR arrays of CP035758_18

>merge|CP035758|18|4005919-4006008|CRISPRCasFinder
TCGTATTACGATATATTTATTATAAATTTTGTTAGTTTTGCTCTTGCTTGCCAGTTATATCGTGTTACGATATATTTATTATAAATTTTG

>CP035758|18|15|4005919-4006008|CRISPRCasFinder
TCGTATTACGATATATTTATTATAAATTTTG	TTAGTTTTGCTCTTGCTTGCCAGTTATA
TCGTGTTACGATATATTTATTATAAATTTTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD77728.1|3994649_3995570_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223999
CP035758.1|QBD77736.1|4008820_4010113_+|NAD(P)/FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|224154
CP035758.1|QBD77739.1|4011615_4012374_-|VCBS-repeat-containing-protein	unknown	unknown	gnl|CDD|379232
CP035758.1|QBD77730.1|3999105_3999321_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD77727.1|3994029_3994461_+|response-regulator	unknown	unknown	gnl|CDD|225114
CP035758.1|QBD77724.1|3991256_3992429_+|hypothetical-protein	unknown	unknown	gnl|CDD|226855
CP035758.1|QBD77729.1|3995922_3998592_+|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|226418
CP035758.1|QBD77731.1|3999605_4002749_+|hypothetical-protein	unknown	unknown	gnl|CDD|225461
CP035758.1|QBD77737.1|4010155_4011049_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|132002
CP035758.1|QBD77726.1|3993366_3993822_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD77725.1|3992425_3993343_-|MBL-fold-metallo-hydrolase	unknown	unknown	gnl|CDD|293840
CP035758.1|QBD77738.1|4011200_4011560_+|hypothetical-protein	unknown	unknown	gnl|CDD|259853
CP035758.1|QBD77740.1|4012782_4013817_-|heme-A-synthase	unknown	unknown	gnl|CDD|224528
CP035758.1|QBD77733.1|4004454_4005546_-|S58-family-peptidase	unknown	unknown	gnl|CDD|239071
CP035758.1|QBD77741.1|4013983_4014937_-|RluA-family-pseudouridine-synthase	unknown	unknown	gnl|CDD|223638
CP035758.1|QBD77742.1|4014923_4015538_-|signal-peptidase-II	unknown	unknown	gnl|CDD|376504
CP035758.1|QBD77732.1|4002888_4004361_+|hypothetical-protein	unknown	unknown	gnl|CDD|311610
CP035758.1|QBD77734.1|4006094_4006589_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224759
CP035758.1|QBD77735.1|4006849_4008118_-|glycosyltransferase-family-9-protein	unknown	unknown	gnl|CDD|223928
CP035758.1|QBD77743.1|4015637_4016036_-|TraR/DksA-family-transcriptional-regulator	unknown	unknown	gnl|CDD|274340

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD77735.1|4006849_4008118_-|glycosyltransferase-family-9-protein	gnl|CDD|223928	COG0859, RfaF, ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane].	2.6196e-52
CP035758.1|QBD77736.1|4008820_4010113_+|NAD(P)/FAD-dependent-oxidoreductase	gnl|CDD|224154	COG1233, COG1233, Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism].	2.64551e-32
CP035758.1|QBD77737.1|4010155_4011049_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|132002	TIGR02957, putative_sigma_factor, RNA polymerase sigma-70 factor, TIGR02957 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building and bidirectional best hits, to represent a conserved family. This family is found in a limited number of bacterial lineages. This family includes apparent paralogous expansion in Streptomyces coelicolor A3(2), and multiple copies in Mycobacterium smegmatis MC2, Streptomyces avermitilis MA-4680 and Nocardia farcinica IFM10152.	1.60989e-105
CP035758.1|QBD77724.1|3991256_3992429_+|hypothetical-protein	gnl|CDD|226855	COG4447, COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only].	5.01351e-05
CP035758.1|QBD77727.1|3994029_3994461_+|response-regulator	gnl|CDD|225114	COG2204, AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms].	8.82558e-14
CP035758.1|QBD77742.1|4014923_4015538_-|signal-peptidase-II	gnl|CDD|376504	pfam01252, Peptidase_A8, Signal peptidase (SPase) II.	3.05065e-39
CP035758.1|QBD77728.1|3994649_3995570_-|alpha/beta-hydrolase	gnl|CDD|223999	COG1073, COG1073, Hydrolases of the alpha/beta superfamily [General function prediction only].	6.69262e-15
CP035758.1|QBD77731.1|3999605_4002749_+|hypothetical-protein	gnl|CDD|225461	COG2909, MalT, ATP-dependent transcriptional regulator [Transcription].	4.28168e-97
CP035758.1|QBD77729.1|3995922_3998592_+|XRE-family-transcriptional-regulator	gnl|CDD|226418	COG3903, COG3903, Predicted ATPase [General function prediction only].	8.98066e-70
CP035758.1|QBD77743.1|4015637_4016036_-|TraR/DksA-family-transcriptional-regulator	gnl|CDD|274340	TIGR02890, conserved_hypothetical_protein, regulatory protein, yteA family. Members of this predicted regulatory protein are found only in endospore-forming members of the Firmicutes group of bacteria, and in nearly every such species; Clostridium perfringens seems to be an exception. The member from Bacillus subtilis, the model system for the study of the sporulation program, has been designated both yteA and yzwB. Some (but not all) members of this family show a strong sequence match to Pfam family pfam01258 the C4-type zinc finger protein, DksA/TraR family, but only one of the four key Cys residues is conserved. All members of this protein family share an additional C-terminal domain. Smaller proteins from the proteobacteria with just the N-terminal domain, including DksA and DksA2 are RNA polymerase-binding regulatory proteins even if the Zn-binding site is not conserved. [Unknown function, General].	1.19021e-16
CP035758.1|QBD77725.1|3992425_3993343_-|MBL-fold-metallo-hydrolase	gnl|CDD|293840	cd16282, metallo-hydrolase-like_MBL-fold, uncharacterized subgroup of the MBL-fold_metallo-hydrolase superfamily; MBL-fold metallo hydrolase domain. Members of the MBL-fold metallohydrolase superfamily are mainly hydrolytic enzymes which carry out a variety of biological functions. The class B metal beta-lactamases (MBLs) for which this fold was named perform only a small fraction of the activities included in this superfamily.Activities carried out by superfamily members include class B beta-lactamases, hydroxyacylglutathione hydrolases, AHL (acyl homoserine lactone) lactonases, persulfide dioxygenases, flavodiiron proteins, cleavage and polyadenylation specificity factors such as the Int9 and Int11 subunits of Integrator, Sdsa1-like and AtsA-like arylsulfatases, 5'-exonucleases human SNM1A and yeast Pso2p, ribonuclease J and ribonuclease Z, cyclic nucleotide phosphodiesterases, insecticide hydrolases, and proteins required for natural transformation competence. Classical members of the superfamily are di-, or less commonly mono-, zinc-ion-dependent hydrolases, however the diversity of biological roles is reflected in variations in the active site metallo-chemistry.	2.23924e-30
CP035758.1|QBD77738.1|4011200_4011560_+|hypothetical-protein	gnl|CDD|259853	cd13831, HU, histone-like DNA-binding protein HU. This subfamily includes HU and HU-like domains. HU is a conserved nucleoid-associated protein (NAP) which binds non-specifically to duplex DNA with a particular preference for targeting nicked and bent DNA. It is highly basic and contributes to chromosomal compaction and maintenance of negative supercoiling, thus often referred to as histone-like protein. HU can induce DNA bends, condense DNA in a fiber and also interact with single stranded DNA. It contains two homologous subunits, alpha and beta, typically forming homodimers (alpha-alpha and beta-beta), except in E. coli and other enterobacteria, which form heterodimers (alpha-beta). In E. coli, HU binds uniformly to the chromosome, with a preference for damaged or distorted DNA structures and can introduce negative supercoils into closed circular DNA in the presence of topoisomerase I. Anabaena HU (AHU) shows preference for A/T-rich region in the center of its DNA binding site.	1.93495e-21
CP035758.1|QBD77740.1|4012782_4013817_-|heme-A-synthase	gnl|CDD|224528	COG1612, CtaA, Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones].	3.62451e-44
CP035758.1|QBD77733.1|4004454_4005546_-|S58-family-peptidase	gnl|CDD|239071	cd02253, DmpA, L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active heterodimeric form. The cleavage results in two polypeptide chains, with one chain containing an N-terminal nucleophile. This group represents one of the rare aminopeptidases that are not metalloenzymes. DmpA shows similarity in catalytic mechanism to N-terminal nucleophile (Ntn) hydrolases, which are enzymes that catalyze the cleavage of amide bonds through the nucleophilic attack of the side chain of an N-terminal serine, threonine, or cysteine.	1.468e-157
CP035758.1|QBD77732.1|4002888_4004361_+|hypothetical-protein	gnl|CDD|311610	pfam07745, Glyco_hydro_53, Glycosyl hydrolase family 53. This domain belongs to family 53 of the glycosyl hydrolase classification. These enzymes are enzymes are endo-1,4- beta-galactanases (EC:3.2.1.89). The structure of this domain is known and has a TIM barrel fold.	6.7371e-05
CP035758.1|QBD77734.1|4006094_4006589_+|MarR-family-transcriptional-regulator	gnl|CDD|224759	COG1846, MarR, Transcriptional regulators [Transcription].	7.8121e-11
CP035758.1|QBD77741.1|4013983_4014937_-|RluA-family-pseudouridine-synthase	gnl|CDD|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	1.63038e-117
CP035758.1|QBD77739.1|4011615_4012374_-|VCBS-repeat-containing-protein	gnl|CDD|379232	pfam13517, VCBS, Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella. This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	0.00545311

Protein sequences

>CP035758.1|QBD77733.1|4004454_4005546_-|S58-family-peptidase
MPRMRLRDLGIRIGRFPTGVFNAITDVPGILVGHKTLIHDEPRVARTGVTMIVPRNGEIWQDHAFAGYFSFNGCGEMSGVQWVEESGKIHTPIGITNTNSVGTVRDAIAAYPAERRDKNLAPAAAAATWDGTLPVAAETWDGWLSDINAFHIAKEHVFEALESAQSGPVAEGNVGGGTGMICHEFKGGIGTSSRLVECPAGQYTVGALVQANYGDRHLLRVNGVAVGRELGFEHVPSPWIEQPKGGSIIVIVATDAPLLPVQCKRLARRATVGLARVGGVGSDGSGDIFLAFATGNHLPYKSGAIHDVKMLSHDQLTLFFEATAEAVEEAILNVLTSAETMTGWRGRTAYALPLDELRRVMGI
>CP035758.1|QBD77732.1|4002888_4004361_+|hypothetical-protein
MSRYSIANQGDGTDMHLIKDSLFGIVRGPLYGHLGAKADVFMPQVHQLGAHLVRLFLFWSQLEPERDHFVWDALDTLLAQLEPHDEVWITLNASSLWASRHATNFQPPSPARDPDEYQRFVTALVSHCQGRISYWQCENEPTNPLLWEGTAQEYAQHLKIFSQAVKQVDPTARVILAGAVDNFHIPADAEHPDAQTEQAFFDHLLRESAAYFDIFDLHAYGELYAIPANILAVRQKMLALGYKKPIVIGEYNGPSFFNFAENLPIMQRLFESIYANPHRDTLAQAIQSEAIAELYAQMADLPPQAQMFMEGCSPELEQKRQRINCRELVIRSVLALSAGVCKLFCWNLANEKVDPHNMMHLLFDKYKLVDYEKGIFKQPYPAAETFRRMVHILAGLEHIQRIEVPEQPDIYLFAVQRKERSPLLISWERRDAFSGEDEPPTPFTWPWPASRAQAIDVFGNELPLKLQAGSLYLSLSATPVFIAAQDESEQ
>CP035758.1|QBD77731.1|3999605_4002749_+|hypothetical-protein
MPRRALNLLKWSQQSQSYELSSSKASAIHEIIPESQAWREWLDTISSFAFHSRCGMRYTVRKEAVQQNGSYWYGYRSWQGRTSKRYLGRTSDLTLARLEEIANNFTAEAASRAGQSLSSTEPLLISRLHPPRLPLGLIERTHLFARLAAWRTYKLTLLRAPAGFGKTTLANSWLAQQQKQQAISHLAWISLQASDNDQLHFWRTIISAYQSWQGEPGKTALTRLASAFRPPFAAVPLETILALFLNDLAKQAGNSILVLDDYHLITEPRLHEALSFFIEHLPLQVHVVILTRNEPNLPLTRWRAQGYLQELSSQDLRFSTIETATFLELTVAASLSAAQLAQLDALLQGWAAGLRLLILAGKMEQAGIERLLSGLEQQQPSNSFRQQLLDYFISEVLDAQPEALQRFLLQTSVLGRLTGSLCDTIMDGQNSSEVLETLELSGLFLEALDEAVRAQTSTILPWYRYHALFAEAMRAEAQRRFGEERLRTIARQASYWYEQHELADAAIEAALQAHDMERAALLIERFSSGAQQIELHILQSWLAQMPEATIDAHPTLCLYAAITLQFQAEPAHPSHSNRTRISALLQKAEEGWRSSGQLTEVGVVFAFRALIASLRETAEQEAVENASKALNLFAVEPGENHIRPTTWQWRTICLGIVGTTAMHQGRFEESQQLLLEALADCQTDGNQEFLREICLRLGTLYQILGKLYQAYEYFQRTLSLGLSQRDYTDCQRALRGLAQLSLEWNDLDAVEQRIHEALELMEQNNQERREDIDYLLALLSFAHGQNISAQLRVSALLARLQTTLIPAVQELLTEVLSLQTRLQLDAHDYLAAQNSLHLLSSSAHELSFGQQMVLHILQVRLLLAQGMEKEAIALLAQLLPVTQEKQYMRGQLELLILLALAHATCKQKAEAHKWLYKALSLAYSEGFLRVFLQEGDAMAHLLRSLLPAIREKTVRAYGQAILRALLSTDAASTPPVSLNDNLPFEPLSGQEQRVLRLLLAGYSNLEIAAELIISVNTVKDHLKHLYRKLGVSNRREVRKAARNLKLS
>CP035758.1|QBD77730.1|3999105_3999321_-|hypothetical-protein
MTFPMLIGIVAIAAIVGFFLLRGRTEPVSCIGLILGCILISMVVLNWNAIGQAVLQMAQTQILPIRLIAVP
>CP035758.1|QBD77729.1|3995922_3998592_+|XRE-family-transcriptional-regulator
METKRSEKNLMPHATPEGELATPDQLLRLFRVRPRVGCKKKLRQIDMAALVGIETRTLQLWECGERLPSPDNLQRLIGALLAERLLLPGEEEQEAQLLWKTVAQAYEERPGTYRLYPPFDERWFRRLLHDATHMLTAEQGLHQEVQAEKRGEHTGSGVPYTPTNLRPHPTSFLGRGPDLAEIKQLLVHTHFVTLTGAGGCGKTRLAQQVGEDMLDQYTDGVWLVELATLTDAALLPGLIATTLALAEQPRHTLLETLVAVLQHKRMLLILDNCEHLVEACASIAEHLHASCPELSLLITSREALNADDETVWQVAPLAVPARSLQSVTAAQIRHTEAVQLFLARARLLLPHFELTDQNAPTIASICQRLDGIPLALELAAARMNLLSLEQLAERLEDRFHLLTAGRRTALPRHQTLRATLDWSYESLSQKEQQLFRRLSVFAGEWTLEAIETICVWPAMETESVGMTIEPREVLDLLAKLVNKSLVLTVSTAQEAGPHAFRYRLLETMKRYGQEQLEEWRGKSTQEQLLLQKHHARYYMELVEQADRHLRSGARETWLVRLRAAQENLRAALAWSLSLQGELEVGMRIAGMLYWFWLHEGIWSEGRSWLEKLLAQAPRYAEHVPLARAVHGLSVLVWVQGERQQAEHLAREAAALALRSGDDCLFATALRLLVQVELSQGNQKTARKFAEESVRLAREQGDHWNLASSLSVLGTVLQAQEEYLQAEQIYQESLHGFEETGDRWEQTGPLRSLGHLAWMQGKYEQAAHFYTRSIALCQGMRGTWLLTRGLEGLARVVCAQGNFPRAVALLAAAEEQRSALGAVVLPTMRADYNHMLSVLRTSLSSQAFEEAWRFGSSMSAEQSMAYALGDDAISLHGRRLSEDSGEHAHE
>CP035758.1|QBD77728.1|3994649_3995570_-|alpha/beta-hydrolase
MQQKAIRYWSEGTACAGTLYLPDTLIPAHKAPAVVLGHGTTYVKEMHLPHFARAFVDAGLIVLTIDYRYLGESQGEPRYKVDPREQAQDYSNAITWLQQQPEVDAEHIGIWGTSKSGGIVLQVAAFDRRVKAVVAQVPDISFWYYMTNALPPEAIQTFLDLMQEERKHMSIGGAPRQIRFSAPQGEASIVGPDWFFWFEQAERDFPTYHNAITVRSIEYMATFDAGAFLNLIAPTPLLMILAEKDEFIPVPFNRAHFDRAGEPKRLFTYNGGHTASYDDPVTREMTAGVARDWFVQYLLRDGRKNQ
>CP035758.1|QBD77727.1|3994029_3994461_+|response-regulator
MAQVGLLEDNARIAKLCSTMLHYAGHEVTIYEGARDCLSALLPQLQLEENNQHGPQLPPSSSLPIDVLILDLHLPDIDGMEVLYSLRSHPQTQTLPLVFCTAAGPSEITRALRIAPQANFVEKPFTFQELITAIANALEAPVS
>CP035758.1|QBD77726.1|3993366_3993822_-|hypothetical-protein
MSEDDNVRKFPISVVRFGMGKEIQLYNDEIVVTGQEDQEIRLQLSVIKRLTLMPGDPNPSKLVLMADLDDGTALILAEGMTNARGFRAMLPQLQELIPDLELDPPDMSEQLRQALNTRRAWTLTCYGTFILVCVLLYALYLIVSYIGAHHH
>CP035758.1|QBD77725.1|3992425_3993343_-|MBL-fold-metallo-hydrolase
MPSSSDQLISVPQMSNDSRVRVFRRHFSEKGEFEGLEVDGYVIISNRYVIVCDTLLCPEDMDILMDEIREELTGRQLLVVNSHADWDHAWGNHYFADSLAVAIIGHEGCRARLLGQEARTELASFQQRYATFSNVVLTPPNVTFKQGMTIYGGDLTIELFHAPGHCHDHIAIWLPEISLLLAFDAAEMPLPIIENRFAVPAMFATLEHFLSLKPQRVLCSHGKTIGVDLVGKNLAYLQEVERRCKMLLQKQRPDAQELEHAAALIQYPLDEVVAGATASKGPVDEAFYSWAHDNNVRCILQWLMR
>CP035758.1|QBD77724.1|3991256_3992429_+|hypothetical-protein
MLTILLCLLLTTLSSCGPSTGIFATGNWQDSGLHQHIRALAVDPNNPGTLYAADTQGHIFYSTDAAQHWNERSTGLSLPNPVHALALDIPGKKLYAATAQGLFVSTDAAQHWNSVLTPTAGLPPDSYTALAFNGNAPDIFYTATAGHGIFISTNGGSSWTSASNGLPQGSAITSLSFAPDTNQLWAATSSHIYQADSKATSWQAADTGLPADISINTVHPASESGGPHGFIYAGTNRGFYLSRDSGKHWSRGQVPLSGTSIHCMLVDFRNTQTTAIYVGTDVGVLASDDNGQNWRNIGSGFPKGQPVYALVLGAESYSQLFAATDNSVYMFPGTNTGFGLTRIITIAAIIVFFYLLYRVADLSRKRRRKNKQAEQTEQAPSEPLPPAPKD
>CP035758.1|QBD77734.1|4006094_4006589_+|MarR-family-transcriptional-regulator
MLMNTKNEIPLADYRALAEFRYQIRRFHHFSEQMARTAGLEPQQHQLLLAIKGLPLGKQATIGELAERLQIQHHSAVELVSRMVDRGFVARQRDEKDQRRVIVHLTTKGEEILLKLSSIALAELRSTGPDLVHALNMLARDKENNLSDENTSEHTAIHKLEDIF
>CP035758.1|QBD77735.1|4006849_4008118_-|glycosyltransferase-family-9-protein
MKQVLHRMFFWLLRLVGSIGMPASSRLASRSNSSAIRILLVHPGHLGSVVLATPVLHAIKLCLPDSHISLLVAPWAKEVVEHHPDVDEVLTCPFPSRREGTLHPIKALPLLWQTGRQLRQGRYDLAINLRRRFWWGAALLLFAHAPLRVGWAVPDAERFLTTAVPRPQRQHVTISFLMIVSAGLQALGYPALDEPYTAERYPEVFVPDEQERQWVETSLQDKNISTDEYVVIVHPGSGAAVKQWRLEGWISCISQIYQAMSATSPVQFILTGSAHERPLLEKIRQGTEAPTTIIPTSTTGQLAALLQRADLVLGVDSGPLHLAVAVGTPTVRIFGPTDPQTYGPWGKVEQHTVITSTSRCASCVEMPCNRLDIPLSQLAKHDCTQRVPEGPVVAATLKQIGWHEEKACQYPRVHAEASTGLD
>CP035758.1|QBD77736.1|4008820_4010113_+|NAD(P)/FAD-dependent-oxidoreductase
MQEVSTTSFDAVIVGGGLAGLTAATILARGGRSVLLLEKASQLGGRAITTEQHGFLFNRGIHALYLTGPGQAILRELDVPYRGKPSERELYEAYTQNSFHTLPINPANLRTTTLLNEEGRTELSSLLKNLTALHPEQLIGTSLQDWLDRSITHPVVRRFVEAMARLATYTHAPHLLDASYTLELVMKRPDALHVDGGWKTLVEGLKNSATAAGAQLETRASVATIETGETEHSIRLTNGKAFQARAVILALEPKIAAQLVVNGPQEILRSYAAQTVPLYAACLDLALRRLPNPERPTVLHFERPMFYSNHARRARLAPEGGALLHLIKYHGPGEKGNADNDRAKLETWLDQVQPGWRDELVAEQFLPHIMVSSDMLQAQRKGLAGRPEPTVPSANHLYIAGDWVGSVDHLANASLVSAAQAARLILARIR
>CP035758.1|QBD77737.1|4010155_4011049_+|sigma-70-family-RNA-polymerase-sigma-factor
METEAIFRNFQPLLFSLAYNMLGSIMDAEDCVQETLLRWEDALKQEEKEAIHSPRSYLCAIATNWCLDHLRKAHVKRETSLSNWLPEPVVRTNLEEQVEIAETLSIAVLRLLEQLTPLERAVFLLRQVFDYEYAEIARMVGKSEHSCRQIIYRARQHLASKRPRYPVSKELHEQFLQRCLQATSQGDMQALLDLLAEDVTLYCDGGELRWPMPLHGSSDVARYLLAINEKVSRETEWSWKLATVNGAPGMLVHAYGRIDAVISCELREGRIQEIDLIVRPDNLQHLQQESIWWGSVY
>CP035758.1|QBD77738.1|4011200_4011560_+|hypothetical-protein
MRSSSSEKNNAILGKDELIHQVAAKAGLNLKETNKVIDAFTEVVREGIAQGHEVRLMGFGTWNLRNVAARKVKSIRGGTQITIPARKRVGFSVGAVLSQAAQDAVEKPSKHINHQTHSR
>CP035758.1|QBD77739.1|4011615_4012374_-|VCBS-repeat-containing-protein
MPVLDTTDKITPKSVLRYRPMGERVAPARKRSIVTTATLPVVPRASRAYYHADVSEDTEEWLRDETEEGISEGSKRYTSRPPVTGASAARPKRKVKRKIHPVLYLSSGMLAMLMLGTIGSAVFGWFNTTLDDLRFGRPRTFQTDAWVGHNEQNGTPSHFIAINLNRHIEIIELPGGDAAHAHIYVGPQLYAQDDDLVPVTLSFADVNGDHKPDMIATYQGTRAVFINTGDGYRPLSEAERPQVEQFLQHLGR
>CP035758.1|QBD77740.1|4012782_4013817_-|heme-A-synthase
MIAHRLMKILAVITSIGAYLMLILGVLVTKTGSGQGCGNSWPFCHGEIIPGTITIAGVVEYSHRIMSSADGFLVLVLTICAWILYKRDFRVKLFAFMSLFFVLLQGALGALTVMYEGTFALKWLLSIHFGLSLIAFASVILLTIRLFQIDREQAGASKGPEAVRKLQYPALGLAIYTYIVVYTGALVAHTGAVTGCGYQIAGCGSTIFPNLTSLAGIQVLHRYGAGLLWLLVLGFLIFALRQARERRDVVRGAWWALILISLQAVSGIINVLTMGQLLAALLHTTLISIFFCELCYLCMQVGWPWKRRNQAAQKVEGSNWSSIQSRKGNSIRFCSLLYLVCDCS
>CP035758.1|QBD77741.1|4013983_4014937_-|RluA-family-pseudouridine-synthase
MYNPDLKSKNENQIWQIDAEQVGQRLDRYLVSVLSDISRTGVQQLIADGLILVNGRPAKAGYLLRLHDEIEALQTAQPQQPLDVQPRAIPLDIAYEDDDLLVVNKAAGMVVHPAPGHYDDTLVNALLARYPQLQAVEGDVRPGIVHRLDRDTSGLMLVAKNVRAQAALIEQMKRHEIMKRYLALVDGNVSLDQGSIDAPIGRDPRHRQQMAVTAVGSRQAITHFRVLQRFARHTLLLVQLETGRTHQIRVHLQAIGYPIVGDPVYGSGNKLRGIALQRQFLHSYQLELIHPASRQKLEIEAPLPDDLQAVLMDESAL
>CP035758.1|QBD77742.1|4014923_4015538_-|signal-peptidase-II
MVIAKRARIYDALALLTVIIVVGFDQWTKALVVENFSPAESKPFVPLIGHYLGILYIQNRGAAFGMLANSEGNILLAALMIVAIGVVLYLYFRMLNSGTLAYKLIFGLIIGGALGNLIDRAHNGGYVVDFLSFRIPEINYYFAIFNIADACISVGVFLLFVFVLFGGFRHGEDNRKEREASPHPLSSSGQKSGALRTTEQDVQS
>CP035758.1|QBD77743.1|4015637_4016036_-|TraR/DksA-family-transcriptional-regulator
MTLDMQQIKQRLESKRADLKRQIGDLTEAHPKPVDPIELSEGPQEFEETAVDFLETQKEQSVLVNEQALLTEVNEALKRIKDGSYGRCVVDGEPIPEKRLEAIPWAARCAKHEQALEERNLSEEELYNADTQ

Crispr_ID: CP035758_20

• CRISPR_ID: CP035758_20
• CRISPR_location: 5649300-5649411
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP035758_20

Consensus_repeat	Method
ATCAAACGTTTCTCTGGTCAGCACTTT	CRISPRCasFinder

spacers of CP035758_20

>20.1|5649327|58|CP035758|CRISPRCasFinder
CGACTCTGCATCATGCATAACTTTCCTTCCTTGAAGAAAGAGTGAAACTGCGGATAAG

CRISPR arrays and Neighbor proteins around CP035758_20

CRISPR arrays

The CRISPR arrays of CP035758_20

>merge|CP035758|20|5649300-5649411|CRISPRCasFinder
ATCAAACGTTTCTCTGGTCAGCACTTTCGACTCTGCATCATGCATAACTTTCCTTCCTTGAAGAAAGAGTGAAACTGCGGATAAGATCAAACGTTTCTCTGGTCAGTACTTT

>CP035758|20|17|5649300-5649411|CRISPRCasFinder
ATCAAACGTTTCTCTGGTCAGCACTTT	CGACTCTGCATCATGCATAACTTTCCTTCCTTGAAGAAAGAGTGAAACTGCGGATAAG
ATCAAACGTTTCTCTGGTCAGTACTTT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD78996.1|5654029_5655199_+|hypothetical-protein	unknown	unknown	gnl|CDD|237885
CP035758.1|QBD78993.1|5650468_5652529_-|PAS-domain-S-box-protein	unknown	unknown	gnl|CDD|227335
CP035758.1|QBD79000.1|5659192_5659513_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD78985.1|5643993_5644227_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD78992.1|5649793_5650345_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
CP035758.1|QBD78984.1|5643502_5643811_+|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|225209
CP035758.1|QBD78990.1|5647449_5648373_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
CP035758.1|QBD78999.1|5658638_5659196_+|ubiquinol-cytochrome-c-reductase-iron-sulfur-subunit	unknown	unknown	gnl|CDD|223795
CP035758.1|QBD78982.1|5642643_5643186_+|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224759
CP035758.1|QBD78983.1|5643188_5643428_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD78987.1|5644948_5645626_+|hypothetical-protein	unknown	unknown	gnl|CDD|319918
CP035758.1|QBD78981.1|5640234_5642154_-|hypothetical-protein	unknown	unknown	gnl|CDD|380492
CP035758.1|QBD78997.1|5655361_5657647_+|formate-dehydrogenase-subunit-alpha	unknown	unknown	gnl|CDD|239155
CP035758.1|QBD78988.1|5645775_5646243_-|4-oxalocrotonate-tautomerase	unknown	unknown	gnl|CDD|224853
CP035758.1|QBD78998.1|5657815_5658625_+|4Fe-4S-ferredoxin	unknown	unknown	gnl|CDD|319891
CP035758.1|QBD78989.1|5646339_5647230_-|RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|224511
CP035758.1|QBD78995.1|5653308_5653671_+|DUF488-domain-containing-protein	unknown	unknown	gnl|CDD|225730
CP035758.1|QBD78994.1|5653046_5653265_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD79001.1|5659644_5660352_+|HPP-family-protein	unknown	unknown	gnl|CDD|377434
CP035758.1|QBD78986.1|5644236_5644611_-|VOC-family-protein	unknown	unknown	gnl|CDD|319962

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD78996.1|5654029_5655199_+|hypothetical-protein	gnl|CDD|237885	PRK15033, PRK15033, tricarballylate utilization 4Fe-4S protein TcuB.	0.00403466
CP035758.1|QBD78997.1|5655361_5657647_+|formate-dehydrogenase-subunit-alpha	gnl|CDD|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
CP035758.1|QBD78986.1|5644236_5644611_-|VOC-family-protein	gnl|CDD|319962	cd16355, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) superfamily. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	0.000130615
CP035758.1|QBD78992.1|5649793_5650345_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	0.000200416
CP035758.1|QBD78984.1|5643502_5643811_+|antibiotic-biosynthesis-monooxygenase	gnl|CDD|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	7.52442e-09
CP035758.1|QBD78990.1|5647449_5648373_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.01896e-24
CP035758.1|QBD78999.1|5658638_5659196_+|ubiquinol-cytochrome-c-reductase-iron-sulfur-subunit	gnl|CDD|223795	COG0723, QcrA, Rieske Fe-S protein [Energy production and conversion].	2.20414e-20
CP035758.1|QBD78982.1|5642643_5643186_+|MarR-family-transcriptional-regulator	gnl|CDD|224759	COG1846, MarR, Transcriptional regulators [Transcription].	3.29975e-19
CP035758.1|QBD78987.1|5644948_5645626_+|hypothetical-protein	gnl|CDD|319918	cd07255, VOC_BsCatE_like_N, N-terminal of Bacillus subtilis CatE like protein. Uncharacterized subfamily of VOC superfamily contains Bacillus subtilis CatE and similar proteins. CatE is proposed to function as Catechol-2,3-dioxygenase. VOC is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	4.03193e-10
CP035758.1|QBD78981.1|5640234_5642154_-|hypothetical-protein	gnl|CDD|380492	cd06268, PBP1_ABC_transporter_LIVBP-like, periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type 1 periplasmic binding fold protein superfamily. They are mostly present in archaea and eubacteria, and are primarily involved in scavenging solutes from the environment. ABC-type transporters couple ATP hydrolysis with the uptake and efflux of a wide range of substrates across bacterial membranes, including amino acids, peptides, lipids and sterols, and various drugs. These systems are comprised of transmembrane domains, nucleotide binding domains, and in most bacterial uptake systems, periplasmic binding proteins (PBPs) which transfer the ligand to the extracellular gate of the transmembrane domains. These PBPs bind their substrates selectively and with high affinity. Members of this group include ABC-type Leucine-Isoleucine-Valine-Binding Proteins (LIVBP), which are homologous to the aliphatic amidase transcriptional repressor, AmiC, of Pseudomonas aeruginosa. The uncharacterized periplasmic components of various ABC-type transport systems are included in this group.	3.70551e-24
CP035758.1|QBD78993.1|5650468_5652529_-|PAS-domain-S-box-protein	gnl|CDD|227335	COG5002, VicK, Signal transduction histidine kinase [Signal transduction mechanisms].	4.78059e-45
CP035758.1|QBD78998.1|5657815_5658625_+|4Fe-4S-ferredoxin	gnl|CDD|319891	cd16369, DMSOR_beta_like, uncharacterized subfamily of DMSO Reductase beta subunit family. This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.	9.37584e-89
CP035758.1|QBD78989.1|5646339_5647230_-|RNA-polymerase-sigma-factor	gnl|CDD|224511	COG1595, RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription].	2.64938e-23
CP035758.1|QBD78995.1|5653308_5653671_+|DUF488-domain-containing-protein	gnl|CDD|225730	COG3189, COG3189, Uncharacterized conserved protein [Function unknown].	1.08904e-51
CP035758.1|QBD79001.1|5659644_5660352_+|HPP-family-protein	gnl|CDD|377434	pfam04982, HPP, HPP family. These proteins are integral membrane proteins with four transmembrane spanning helices. The most conserved region of the alignment is a motif HPP. The function of these proteins is uncertain but they may be transporters.	6.21749e-24
CP035758.1|QBD78988.1|5645775_5646243_-|4-oxalocrotonate-tautomerase	gnl|CDD|224853	COG1942, COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only].	6.20417e-07

Protein sequences

>CP035758.1|QBD78990.1|5647449_5648373_+|alpha/beta-hydrolase
MEKKALLALSAATLTGLGALTVTENYQQWQRSELARLESGSQLIETALGPTEFASSGSGPTILILHGSPGGYDQALNLGPALGLTNFSILAPSRPGYLRTPLSSGRSPEAQADLCAALLDALHIETAIVLGISGGGPSALQFALRHPEHCRALITLCAVTQRYNESEVYAQLALHQRLLNQLTDAALLSNACIYILQGLTDLVSTSEHPETKDMLKSFSLPSLRRPGYDNDMQQFASMDIYPVEQLAMPTFIAQGTADTSVPFAQAQWLASKVPQARFVAVEGAGHMFFATHKDQVVPQLHSFLHAL
>CP035758.1|QBD78989.1|5646339_5647230_-|RNA-polymerase-sigma-factor
MVEYDLLKHTLEDSVEAAKTGDRAALEAVIASIQDRIYGIAMRMLGHPQDAQDATQEILVKIALSLRSFRQETLFSIWAYRIAINHLITIRKRRNKMSALSFEQFSQFLEAGLLNSSLAPASVDQQLLMEEVKIGCTQGMLLCLNQELRVAYILGEVFEVNSQEGADILDITPEAFRKRLSRARKLLRGFMYKNCGIINPANPCRCHKQVGPAIQAGLIKEDSLMFACHPTRVSSTRTQEVRELEKLDRVAGLYRNHPDYAAPEAFVIAMKELLASRQFALLSSEEENAQVENISS
>CP035758.1|QBD78988.1|5645775_5646243_-|4-oxalocrotonate-tautomerase
MPMIDLTLPEGILNAQGKQDLMAHLSSIILKWEGAPDTPQAKAIAWIYVHEIKKEEMMVGGAFPAHPRYRVIATVPQWSLDDERKQGLVEEVTRAILDAEGASWDAENRARVWCIVQEVADGNWGAGGQIFRLRDIVRLVGGDPDSARFRGLPIS
>CP035758.1|QBD78987.1|5644948_5645626_+|hypothetical-protein
MHIQELVLYTSSLASQKQFYSQALGLSLVDERPDSFTVQAGLTRLSFHETKQNVLYHIAFTIPRNKFARAKDWLVRQQIPFLRKDGEDEIFFDNINARSCYFPDPDNNILEFIVHYNLARETDGDFSPADVLHVSEIGLPVEDVPALATKFEETLGLKPYGGPVSEGFAFMGDITGQLVVTKIGRPWLPTLTVPAAPSPVQVTLSGTRKQWLDLAPYPYILTAHQ
>CP035758.1|QBD78986.1|5644236_5644611_-|VOC-family-protein
MKVLQVLTRIFLSREQLEASVSFYESLFSTQSSLRESFEGGIEAVQVGPLLLIAGPEQALGALKATQANFLVDSLSEWQAYLRKNGATILDGPKQAPTGMEMRVRHPDGTWIKYVQYEDSVYSC
>CP035758.1|QBD78985.1|5643993_5644227_+|hypothetical-protein
MHANLPALQAVLKQLAKALARYATLVFHNGYYSLEQHATSYDDHEIFQTFEQRQVPDRELLYRVFFGGRLKTGQAEP
>CP035758.1|QBD78984.1|5643502_5643811_+|antibiotic-biosynthesis-monooxygenase
MSIVLINPFEVPLGQEENFRQGWQAAAEHLRQAPGFISTRLHESLDKEARFRFINVAEWESPQHFQAAMRSEAMAQVRQHMHFTAYPALYQVIVEEKSSSSH
>CP035758.1|QBD78983.1|5643188_5643428_+|hypothetical-protein
MPARKVSNKQIRDIQRIVHLIAALVLLFYVYGPLDGAPGLAPLLRFAVLPLLVVTGLLMWQWTRLRKLVTPSLRGTALP
>CP035758.1|QBD78982.1|5642643_5643186_+|MarR-family-transcriptional-regulator
MQERESPSYQIVRSRDDLKDLESQGDPAQIFIIEESLGYLVNYLARLFSQIHTAYLASHGVHLGQWGVLMYLWVKDGQTQRELSRQVAIDEASMVSSIDRMERNGLVRRVRNDHDRRQINIFLTEKGRALRDKLIPGALANNAISVNGLSEAEKNQLFTLLRRMIVSLEEALAHQQERTT
>CP035758.1|QBD78981.1|5640234_5642154_-|hypothetical-protein
MSQQNQSSGNQQNGPASPNPPATNTNIIPWFQLLVAIISNIAYIKINAPDLFSLLLFNVVALGGISLYKIHPDTINNINGWIDNAFGKVFGPVKRRFSKMFSGTQTTSQLRARKHFTHVVLYLAYILIIIIFLFQNFFIAKLSAAADYACVKGGVQLFCAPGIGVSSLMAPDHTMVRVGLISNTNEMELPFDWTGSSGADQEIEVEKKILQEQNIQNHACSGKHITLAVVTILSRTVSDSALSADVGLEDLRGAYLAQQDYNSRPNVDNARLCLVIANIGTQATAQEALPGVVRQLILYAKSDPSFLGIVGVPFSAQADQALQALNNWGQGAIPIISPSVTSDDFSHKPNFYRIAAPDEVQSDMMAKFIKRYFVSGPCPQVKPTIAVFYDINKGTNQPDQYSNSLASAFINALQNNGVCAKPVSVPYIIGDNTVIEANVQDAIVNKAATMIFFAGYANDIDAVEYGVQLAQQQQSPAAKVSIPIFAGDAVYDLTRYVDNTYSIVYSTIYAPPLNRQSDFVRAYYQAFPQPLPTSKVVTLNAYTLLPPHAILSYDATKAFLQAFENTRDKTDQQDFDKHLATVEFTGVNDEDIVLQGNNSSNPGHKSVYILCTDHAHAIQVAAASDGSYPSLGDVQRCTK
>CP035758.1|QBD78992.1|5649793_5650345_-|GNAT-family-N-acetyltransferase
MTFATWWRGDPLPDLAPLPTFSAHLSSDIHLISQVTNRPLEAITPRLQEGNRPYLAFMGEAPVAYGWVATQEGSISDLGMYFALPAGNCYLHSFRTLPAWRGQGIYPRLLQTIIQQEQSFERFWIGYMPSNIASGRGIQKAGFHVVSDLAFVKGRVCGITLFEKSERALASAAVFQLPVVSTT
>CP035758.1|QBD78993.1|5650468_5652529_-|PAS-domain-S-box-protein
MPARKGTMEHEQQFMGPPGEGDDALSDQAAISQRMSPKHSADRLRALAAATADLLWFVAERQEAQEDNAAWLAFTGQASESMWSWLAAVHVEDQQRIKEACTAMATGADAEEIIECRIRRYDGQFRVFRVRLLPLREPDGELYELMCVGTDITDEQQKGRALAERVTLLEAVFEHMDDAVYVYDTLGQPIYVNTAGRELFAGEYLPGMPFSIDPGGIHVCAYDEQENLLPSERWPLVRVFQGEELNPGQLVHIYARKGHEDPRHVHISARAIIDNQGQVLGAVVVCCDVTERYLLEQVERRRAQENDARRAMLQLILDELPYGVYLVRGQDARLVFINRAAAELWGALWQIGQPMQEFLQQQRLAVFKHDGSQEDREQMAAFRVIRSGRPVHDHWVAIRRQDNKSVPVLINAVRLSGELLSLLITDEPEEAANELDVAALVVMQDVTTLHEGEQLKDQFISLIAQELREPLGLVKDFAQTLVQQAVREDSVAFTEWQLEAIRSILNASVYLTELTDDLFDVTRLEAGLLTLQRSSADLVALVRQVVARLQDSTSRHTLMIFTSLERLFVSVDPVRIEQVLSHLIGNAIKYSPQGGPIEITLRKDVRANDVLISIRDYGIGIPQPSQVDIFDRFTRAANARAYGIAGTGLGLYLCRELVERHGGRLWFGATEGRGSTFFITLPAESS
>CP035758.1|QBD78994.1|5653046_5653265_+|hypothetical-protein
MIDKRNVFDEEVFTYRLTKDNKVFLFWYNKHVKTLKGPEAQKFLRQIAGAEKTEQQLIMAKLTGNFKRGNER
>CP035758.1|QBD78995.1|5653308_5653671_+|DUF488-domain-containing-protein
MSEHIAIKRAYDEPATEDGKRILVDRLWPRGLSKERAHIDLWLKEVAPSSELRKWFGHEPEKFAEFRRRYTAELSAGQGQQALDQLAAIARQEPLTLVYAAHDSAHNNAAVLRELLSQVH
>CP035758.1|QBD78996.1|5654029_5655199_+|hypothetical-protein
MAQSSVQATMQETRAAQPSPGKRRSNLRLRSIFYGILAAIVVTALIAIGSRGFHWFDAALIGYAVATVFAVAAVTYKYSFWLMRPPTGRYWKRSWQLFLSYANFRRYTTLIPGAIGDLFVQSFIRRRGLYRWLTHQCIFWGVILSCLITFPLTFGWLRFTQTTTGLYQVWFFGFPLIVFPVASVQGFVLYHALDITALILFVGLVLAFHRRFHDLALIAVQRFRFDLVPLALLMAIAVTGLALTADSSWLRGSYYWYISLVHEAVVVLWLISLPFGKFFHLIERPATVGIELYWRTGEETEKQHCARCGQEFAPVRFIQDLKKTLYEVGENYTLRDTPALPEQKLAANASPLERETSKLWWQDLCPSCKRVMRGQANLAALGREGNKFL
>CP035758.1|QBD78997.1|5655361_5657647_+|formate-dehydrogenase-subunit-alpha
MSVDKGIFRRNKQAETFDFHSGQRPAHWKSEEQIDRYVPTHCCYCGVQCGMYLKVANGKVVGVEPRADFPLNHGMLCPKGSTAYQTVNHPDRLTYPLMRRNGKDSPLERASWDEVLDTIARRFRELQAQYGNDTVSIYSGSSMTNEKCYLMGKFARVAVGTRHTDYNGRLCMSSATGANERSLGIDRAANPISDMLHADCIFVIGANVGECFPITTSYLWQARDRGCKLIVADPRQTPIARTADVYLPLRSGTDSALLNGMLHVIVKEGLIDEDFIRERTNGWEETMALVEQYPPERVAKVCGLRPEAIVEAAHMYGRANAALIYTARGLEHQSKGVDNGVTAANLALATGNFGRPGAGYGTLTGQGNGQGGREMGQKASQLPGERDVEDPEDRAYICSVWGIDEKDLPHSGYPATLMIPAMLRQEIRACFMICSNPMVSLPDQHTVERALRGLDLFVVTDFFLSETAELADIVLPGSVWAEDEGTVTSLEGRVIKYNKAVEPPGEARVDWEIVCDLARRLGKGQYFDFHSARDIFNELRKCTKGAKSDYWGITYEKIAEQNGVFWPCPSEDHPGTPRLYEKRFGFPDGKARFHPIPYIPPAEEPNAEYPLVLTTGRVIYHYLSGNQTRRTPFLKEMAPYPWVEIHELTAARLEINDGDWVTVSTRRGEMTAPALVVRSIRPDTLFIPYHYGHTQAVNQLTNPVLEPMLKIPEYKVCAAKAVRASQRPDWAKDIDVHELIEARKHRHELPMAQNKPVPTFR
>CP035758.1|QBD78998.1|5657815_5658625_+|4Fe-4S-ferredoxin
MVDTIKRIFLDPSRCIGCRSCVAACRECDTHKGESMVYIDYVERHNTVATSPSLCMHCEDPLAPCAQVCPAQAILVSPDGVVQSADETRCIYCENCGYACPFGIPKFNMAGHYMQKCNLCYDRTSQGKGPMCATVCPTQAIFYGTYEDWLEAGRGRQGAKPVNTFYFGHQRVRTRNYVVMTQEDEGLDLLALVEEANLGQGMHLPAPTANDNYEEWVPAETAGIPERAAPPQPWTPRTPEPQPGREPVPSHSTNRVAEPISVVRVPTNF
>CP035758.1|QBD78999.1|5658638_5659196_+|ubiquinol-cytochrome-c-reductase-iron-sulfur-subunit
MIQEVDPQSEATKQRRSTGEANPPARRNEEWREEFPYPWDEDEIVTRRDTLRFLLGGSGALFAATGILAILGNLPKGPDVQAVPVAKLGELKENEWKVFDFPDQYAQGILINLPRKGLVAYSDVCTHLSCAVVYRENGTLHCPCHEGLFDASTGNVLAGPPTRPLPLIELAIEGDTIYAVKVVPR
>CP035758.1|QBD79000.1|5659192_5659513_+|hypothetical-protein
MSKRIQIHQPVANPDDPPVQKPPQGPKGPLPGPNYLGLAGRIAIVQGQVFIVAIILIAQLWIITDALYELLSGRTDSLGWLTLVSAIGFALALLVTFWPRRSIEGS
>CP035758.1|QBD79001.1|5659644_5660352_+|HPP-family-protein
MDPETRPPSQPTQAKPTSPLPPGYARIDREHPIGGQMSDIVQGLFTRTRLPWLLQHHSQVAVLAIFSFINGCISIGLMSILAVITGSPFIFPSLGPTAFLFFYTPTAPSASPRNTLVGHAVGALAGYLSLIITGLTTAGPALSVGVTWPRVFAAALSLGLTAGVMVLLKSPHPPAGATTLIVSLGILKEPWQLLLLMIAVLLLTLQAIAINRLAGIPYPLWSPLRNPPADLGKGT

Crispr_ID: CP035758_23

• CRISPR_ID: CP035758_23
• CRISPR_location: 7060633-7060729
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP035758_23

Consensus_repeat	Method
CCCCGTGTTCCCCTTCTTGTGGAGTGGAG	CRISPRCasFinder

spacers of CP035758_23

>23.1|7060662|39|CP035758|CRISPRCasFinder
ATGCAAGGGACGTCAGAACCTTGCCGGGGTACGGGGTGC

CRISPR arrays and Neighbor proteins around CP035758_23

CRISPR arrays

The CRISPR arrays of CP035758_23

>merge|CP035758|23|7060633-7060729|CRISPRCasFinder
CCCCGTGTTCCCCTTCTTGTGGAGTGGAGATGCAAGGGACGTCAGAACCTTGCCGGGGTACGGGGTGCCCCCGTGTTCCCCTTCTTATGGAGTGGAG

>CP035758|23|20|7060633-7060729|CRISPRCasFinder
CCCCGTGTTCCCCTTCTTGTGGAGTGGAG	ATGCAAGGGACGTCAGAACCTTGCCGGGGTACGGGGTGC
CCCCGTGTTCCCCTTCTTATGGAGTGGAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD80117.1|7065833_7066304_+|50S-ribosomal-protein-L13	unknown	unknown	gnl|CDD|181703
CP035758.1|QBD80100.1|7053933_7054119_+|type-Z-30S-ribosomal-protein-S14	unknown	unknown	gnl|CDD|181216
CP035758.1|QBD80102.1|7054604_7055180_+|50S-ribosomal-protein-L6	unknown	unknown	gnl|CDD|235495
CP035758.1|QBD83640.1|7066373_7066748_+|30S-ribosomal-protein-S9	unknown	unknown	gnl|CDD|178888
CP035758.1|QBD80111.1|7061628_7062012_+|30S-ribosomal-protein-S13	unknown	unknown	gnl|CDD|235358
CP035758.1|QBD80112.1|7062034_7062433_+|30S-ribosomal-protein-S11	unknown	unknown	gnl|CDD|180007
CP035758.1|QBD80104.1|7056696_7056891_+|50S-ribosomal-protein-L30	unknown	unknown	gnl|CDD|180163
CP035758.1|QBD80110.1|7061444_7061561_+|50S-ribosomal-protein-L36	unknown	unknown	gnl|CDD|376334
CP035758.1|QBD83639.1|7055669_7055894_+|hypothetical-protein	unknown	unknown	gnl|CDD|235524
CP035758.1|QBD80115.1|7064354_7064984_+|50S-ribosomal-protein-L17	unknown	unknown	gnl|CDD|376486
CP035758.1|QBD80114.1|7063372_7064353_+|DNA-directed-RNA-polymerase-subunit-alpha	unknown	unknown	gnl|CDD|235359
CP035758.1|QBD80105.1|7056877_7057408_+|50S-ribosomal-protein-L15	unknown	unknown	gnl|CDD|235523
CP035758.1|QBD80103.1|7055986_7056685_+|30S-ribosomal-protein-S5	unknown	unknown	gnl|CDD|234790
CP035758.1|QBD80107.1|7059104_7059755_+|adenylate-kinase	unknown	unknown	gnl|CDD|234711
CP035758.1|QBD80109.1|7061037_7061259_+|translation-initiation-factor-IF-1	unknown	unknown	gnl|CDD|178954
CP035758.1|QBD80116.1|7065022_7065850_+|tRNA-pseudouridine(38-40)-synthase-TruA	unknown	unknown	gnl|CDD|234577
CP035758.1|QBD80108.1|7059827_7060577_+|type-I-methionyl-aminopeptidase	unknown	unknown	gnl|CDD|235576
CP035758.1|QBD80106.1|7057657_7058995_+|preprotein-translocase-subunit-SecY	unknown	unknown	gnl|CDD|236412
CP035758.1|QBD80113.1|7062476_7063103_+|30S-ribosomal-protein-S4	unknown	unknown	gnl|CDD|235411
CP035758.1|QBD80101.1|7054195_7054591_+|30S-ribosomal-protein-S8	unknown	unknown	gnl|CDD|234658

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD80117.1|7065833_7066304_+|50S-ribosomal-protein-L13	gnl|CDD|181703	PRK09216, rplM, 50S ribosomal protein L13; Reviewed.	3.19363e-91
CP035758.1|QBD80100.1|7053933_7054119_+|type-Z-30S-ribosomal-protein-S14	gnl|CDD|181216	PRK08061, rpsN, type Z 30S ribosomal protein S14.	4.74283e-34
CP035758.1|QBD80102.1|7054604_7055180_+|50S-ribosomal-protein-L6	gnl|CDD|235495	PRK05498, rplF, 50S ribosomal protein L6; Validated.	9.69375e-96
CP035758.1|QBD83640.1|7066373_7066748_+|30S-ribosomal-protein-S9	gnl|CDD|178888	PRK00132, rpsI, 30S ribosomal protein S9; Reviewed.	2.12037e-57
CP035758.1|QBD80111.1|7061628_7062012_+|30S-ribosomal-protein-S13	gnl|CDD|235358	PRK05179, rpsM, 30S ribosomal protein S13; Validated.	4.68293e-78
CP035758.1|QBD80112.1|7062034_7062433_+|30S-ribosomal-protein-S11	gnl|CDD|180007	PRK05309, PRK05309, 30S ribosomal protein S11; Validated.	8.18509e-87
CP035758.1|QBD80104.1|7056696_7056891_+|50S-ribosomal-protein-L30	gnl|CDD|180163	PRK05611, rpmD, 50S ribosomal protein L30; Reviewed.	1.58458e-26
CP035758.1|QBD80110.1|7061444_7061561_+|50S-ribosomal-protein-L36	gnl|CDD|376334	pfam00444, Ribosomal_L36, Ribosomal protein L36.	1.14005e-11
CP035758.1|QBD83639.1|7055669_7055894_+|hypothetical-protein	gnl|CDD|235524	PRK05593, rplR, 50S ribosomal protein L18; Reviewed.	1.2175e-23
CP035758.1|QBD80115.1|7064354_7064984_+|50S-ribosomal-protein-L17	gnl|CDD|376486	pfam01196, Ribosomal_L17, Ribosomal protein L17.	1.34348e-25
CP035758.1|QBD80114.1|7063372_7064353_+|DNA-directed-RNA-polymerase-subunit-alpha	gnl|CDD|235359	PRK05182, PRK05182, DNA-directed RNA polymerase subunit alpha; Provisional.	4.14192e-160
CP035758.1|QBD80105.1|7056877_7057408_+|50S-ribosomal-protein-L15	gnl|CDD|235523	PRK05592, rplO, 50S ribosomal protein L15; Reviewed.	5.21246e-58
CP035758.1|QBD80103.1|7055986_7056685_+|30S-ribosomal-protein-S5	gnl|CDD|234790	PRK00550, rpsE, 30S ribosomal protein S5; Validated.	1.28241e-82
CP035758.1|QBD80107.1|7059104_7059755_+|adenylate-kinase	gnl|CDD|234711	PRK00279, adk, adenylate kinase; Reviewed.	9.01278e-104
CP035758.1|QBD80109.1|7061037_7061259_+|translation-initiation-factor-IF-1	gnl|CDD|178954	PRK00276, infA, translation initiation factor IF-1; Validated.	8.314e-37
CP035758.1|QBD80116.1|7065022_7065850_+|tRNA-pseudouridine(38-40)-synthase-TruA	gnl|CDD|234577	PRK00021, truA, tRNA pseudouridine(38-40) synthase TruA.	1.42832e-111
CP035758.1|QBD80108.1|7059827_7060577_+|type-I-methionyl-aminopeptidase	gnl|CDD|235576	PRK05716, PRK05716, methionine aminopeptidase; Validated.	2.6025e-131
CP035758.1|QBD80106.1|7057657_7058995_+|preprotein-translocase-subunit-SecY	gnl|CDD|236412	PRK09204, secY, preprotein translocase subunit SecY; Reviewed.	1.35174e-172
CP035758.1|QBD80113.1|7062476_7063103_+|30S-ribosomal-protein-S4	gnl|CDD|235411	PRK05327, rpsD, 30S ribosomal protein S4; Validated.	1.28389e-112
CP035758.1|QBD80101.1|7054195_7054591_+|30S-ribosomal-protein-S8	gnl|CDD|234658	PRK00136, rpsH, 30S ribosomal protein S8; Validated.	3.61253e-77

Protein sequences

>CP035758.1|QBD80108.1|7059827_7060577_+|type-I-methionyl-aminopeptidase
MAIILKSKEERAKIRETGRIVAEILAELRNAVHPGITTAEIDKLCREALARRGAKSSSLGYHGYPASLCTSVNDEVVHGIPGERVLAEGDIITLDLAASYNGWHADSAITVPVGTVKAEDQQLLKVTEDALYQGIAAARAGNHLQDIGRTVQQFVEAAGYSVVRQYGGHGVGRHMHEDPQVLNYVERGYPNYILKPGMVFAIEPMVIMGKKETQVLADDWTVISADHSMTAHFEHTIAVTTGDAEILTL
>CP035758.1|QBD80107.1|7059104_7059755_+|adenylate-kinase
MNIILIGAQGSGKGTQAEKLAQVLGVLHVASGDLFRSAIAQGTELGMKAKIYIDRGDLVPDDITVAMVLSRLQEPDCARGVLLDGFPRTLEQAKALDRGLQEADRFIDTAVYLEVPREILLKRLSGRYICRANQHIYNINTRPPKVPGICDLDGSELYQRSDDQGEAVQKRLDIFFNGTFKLLDYYRDEGKLATVNGNQDVEKVHKDLVKAITDRL
>CP035758.1|QBD80106.1|7057657_7058995_+|preprotein-translocase-subunit-SecY
MWERLRSIWKAPDLRNKILFTLGLLLVFRVLANITVPLTPDEHNALVQLFNTNKNGNLGQLLGLMDVFSGGSLQTFSIVAFGVYPYITATIVMQLLQPIIPALQNLSTQGEAGRLKFSQITRIITVPLAFLQALGQCAIYQKAGVLKNFSLIDPQYALNTWAIMFALIAGTMILVWLGELITEKGIGNGISLIIFGGIVSRIPQFVQQGYIAATSGGGSGSGVISIAVFLIIGLITIVGIVYIYQGQRRVPVQYPTKRQVGRGMLVGSAQTTYIPMQVNSAGMIPLIFAQSMLLFPAVISQYLTTSNVGWLKDISVWVATYLVNTQQWWYWALYFLLVVAFTYFYAYVMWQQQNIPENLQKQGAFIPGYRPGEPTSRYLSNILNRITLGGALFLGIVAILPFVARVGANQLLGSASLLIVVGVVLDTVRQLESQMVMRNYSGFLS
>CP035758.1|QBD80105.1|7056877_7057408_+|50S-ribosomal-protein-L15
MKLSDLRPAPGSHKAERRVGRGHGSGRGKTAGRGTKGQKARTGGSIHRAFNGGQTRLSKRLPFQRGMGAARNSFSALQDVYTVINVVDLVDLFEAGAQVRPENLVEQKVLTPAEARGLIKILGDGEIDRPLTVHAHKFSASARAKIEAAGGSVEIIPTKVYEKTKRRKDDTAKAQQ
>CP035758.1|QBD80104.1|7056696_7056891_+|50S-ribosomal-protein-L30
MAKLRVKWVKSSIGYPKDQKTTIRALGLRKLQQTVEQDDQPAVRGMIRKVRHLVQVEEIISETL
>CP035758.1|QBD80103.1|7055986_7056685_+|30S-ribosomal-protein-S5
MARIDASKLNLEETVVEVSRVSKVHQGGRRFSIRALVVVGDRNGYVGFGFGKAGEYTEAIRKGVEDAKKHLIQVPLAGTTIPFMVKTTFGASEVLLKPAAPGTGVIAGGAVRAVMEAAGVRDILTKTLGSTNKANTVQACLQALRELRSPEAEAARRGKTVAEILGKKRAEQIAVAAANAAEQAAAARAAREEEARENRALAGRRGGDRDRRGGDRGDRGSRRSGGSGDRRR
>CP035758.1|QBD83639.1|7055669_7055894_+|hypothetical-protein
MPAAQKGETKTPVEALVAIANNRRVALAREVGKLVAQRAKEQGVSRVVFDRGGYAYHGRIAALAEGAREVGLDF
>CP035758.1|QBD80102.1|7054604_7055180_+|50S-ribosomal-protein-L6
MSRIGRAPIAVPPKVQVSWNEDNLVTVKGPKGELSYKVDSALQLKLEDGQLTINRPSESKEHKAKHGLYRTLVNNMVVGVTSGYTKQLEIHGVGYRASKVGDSLIILVGYSHPVEVQPPTGITLNIDGVDAATKATKVSVSGIDKQLVGEVAASIRRIRKPEPYKGKGIRYAGEKIRRKAGKAGKVGGKKK
>CP035758.1|QBD80101.1|7054195_7054591_+|30S-ribosomal-protein-S8
MNMTDPIADMLTRIRNAATARHTRVLIPASKMKLGIARVLKEEGYIKDIEILKDNPQGTIRLTLRYVDKKPVLTQLKRVSKPGLRVYTKKAGIPRVRGGLGVAILSTPRGLMTGSSAYKQGLGGEVICYVW
>CP035758.1|QBD80100.1|7053933_7054119_+|type-Z-30S-ribosomal-protein-S14
MAKISMIVKSQRKPKFKVQQHNRCNVCGRPRAYIRKFGLCRICFRERALRGELPGVTKSSW
>CP035758.1|QBD80109.1|7061037_7061259_+|translation-initiation-factor-IF-1
MPKKDEIEVEGRVVEALPNAMFKVEIDEHHEVLAVLSGRIRMNFVRIVPGDKVRVVLSPYDLTRGRITWRVKA
>CP035758.1|QBD80110.1|7061444_7061561_+|50S-ribosomal-protein-L36
MKVRASVKPRCDGCKIIRRNRVVMVICSKDPKHKQKQG
>CP035758.1|QBD80111.1|7061628_7062012_+|30S-ribosomal-protein-S13
MARIAGVDIPREKRVEISLCYIFGIGLTTSRKILERTRINPDTRVKDLTEEEVNRLREVIDREHKVEGDLRREVDMNIKRLIEIGCYRGMRHRRNLPVRGQRTRTNARTRRGPKRTVAGKKKASAKK
>CP035758.1|QBD80112.1|7062034_7062433_+|30S-ribosomal-protein-S11
MADKKRPTGKVRRRERKSVPRGQAHIQATFNNTIVTLTDPNGNVLSWGSAGSQGFKGSRKSTPYAAQVTAETAARKAMDHGLRQIDVYVKGPGSGREAAIRSLQSAGLTVSSITDVTPIPHNGCRPPKRRRV
>CP035758.1|QBD80113.1|7062476_7063103_+|30S-ribosomal-protein-S4
MARYTGPVCKLCRREGVKLFLKGDKCMTHCTLERRSSKPGQHGSGRSRKESGYAKQLREKQRVRRTYGILERQFHKHFDAAARRPGKTSENLLQILEMRLDNLVYRLGFADSRAQARQLVCHGHFAVNGRKTDIPSFIAKPNDVITVRERSKGLEYFKARALLLAQKGVPAWLSLDTNEMSGRVITVPSRADLELPFDEQMVVEYYQR
>CP035758.1|QBD80114.1|7063372_7064353_+|DNA-directed-RNA-polymerase-subunit-alpha
MLDITLPRIKNTKTQGNYASYDIEPLEAGYGMTLGNALRRVLLSSLPGAAVTSIRIEGVQHEFQDIPGVMEDVTDIVLNVKRLRLRSFSDHPVSMRLEVSGEREVTAADIAAPSTIEIVNPELHIATLDSDNARLDMELVVEAGRGYVPADSKEDQPIGVIPVDAIYTPVQKVNYTVEHTRVGQMTNYDKIVLEILTDGTITPDDALHQSADILVRHFTLLANYRAAVPEIEKPPLSSLPIPQKIYDTPIEELDLSVRAYNCLKRSNITKVGQVLSMNEEDLLGVRNFGEKSLQELRERLLARNFLPNPRTSTVGADTDGDHEMEE
>CP035758.1|QBD80115.1|7064354_7064984_+|50S-ribosomal-protein-L17
MRHRVAGNRMNMPEPRRRSARRNMMAGLIRYDRIQTTEARARAIRGEVEKLIHKAIEGHKSAQAYLAAAVPDQEKAAQILAFARRGRFSLDLKVASNNEERLAQGKSPLTSQGRKFLEDKLKGRRDELLRIFSDEGEAEKALQAAYQAMVIELHARRTILSALPDELVVKKMFEELAPRYATRNGGYTRITKLGRRKGDAAEMAQIALV
>CP035758.1|QBD80116.1|7065022_7065850_+|tRNA-pseudouridine(38-40)-synthase-TruA
MYAKIYAMNIACTVEYDGTDYHGFQRQPDSHGPTVQGTLEAAIARISGEMSTVHGAGRTDAGVHASGQMINFHTRSHLTPQVWQRALNAVLPGTVAIRWAGEVPERFHSRFSALSRSYRYTIWNNGARSALRARYSFHSPRPLDVDLMQEACQLLLGRKDFGAFGRSPDETNPLKPGPHHCIRTMLEARCLREEAQQGLIFCDFTADAFLTGQVRRMVGTLVLVGQKRLCLAEFASIVERADKTHPGSVAPSHGLCLVRVRYPEKFGVTNNDEDI
>CP035758.1|QBD80117.1|7065833_7066304_+|50S-ribosomal-protein-L13
MMKTYSAKAADLQPTWYVIDAEGQILGRVASQIAQILRGKHKPTFTPHLQSGDFVVVINADKIAVTGRRLDQKIYYRHSQYPGGLKQRTLRQTLEGKHPERALEHAVRGMVMHNRLGADIMKRLKVYAGSEHPHQAQKPVPWTGPEALLKQPAKAE
>CP035758.1|QBD83640.1|7066373_7066748_+|30S-ribosomal-protein-S9
MGRRKTAVARVRVFPNGDGSITVNGKNAQAYFGQREAYMATIAAPFRALDLNNNYTITIRVVGGGTNGQAGAIRHALARALVRMNGDFKASLRKAGYLTRDPRMKERKKPGLKRARKAPQYTKR

Crispr_ID: CP035758_24

• CRISPR_ID: CP035758_24
• CRISPR_location: 7307552-7307644
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP035758_24

Consensus_repeat	Method
TCTTTTTTAAGACTTTCTGCTTAT	CRISPRCasFinder

spacers of CP035758_24

>24.1|7307576|45|CP035758|CRISPRCasFinder
ACCCCTAGAGTGATCACAGAATTTGGCTCACCATGGGCAAGTCCC

CRISPR arrays and Neighbor proteins around CP035758_24

CRISPR arrays

The CRISPR arrays of CP035758_24

>merge|CP035758|24|7307552-7307644|CRISPRCasFinder
TCTTTTTTAAGACTTTCTGCTTATACCCCTAGAGTGATCACAGAATTTGGCTCACCATGGGCAAGTCCCATCTTTTTAAGACTTTCTGCTTAT

>CP035758|24|21|7307552-7307644|CRISPRCasFinder
TCTTTTTTAAGACTTTCTGCTTAT	ACCCCTAGAGTGATCACAGAATTTGGCTCACCATGGGCAAGTCCC
ATCTTTTTAAGACTTTCTGCTTAT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD80318.1|7314950_7315694_+|50S-ribosomal-protein-L10	unknown	unknown	gnl|CDD|234632
CP035758.1|QBD80311.1|7309534_7309762_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD80300.1|7296534_7296696_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD80302.1|7298895_7299285_-|PPOX-class-F420-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274679
CP035758.1|QBD80319.1|7315724_7316108_+|50S-ribosomal-protein-L7/L12	unknown	unknown	gnl|CDD|234671
CP035758.1|QBD80304.1|7300878_7301271_+|transcriptional-regulator	unknown	unknown	gnl|CDD|224647
CP035758.1|QBD80308.1|7306478_7307525_+|ribosome-small-subunit-dependent-GTPase-A	unknown	unknown	gnl|CDD|234631
CP035758.1|QBD80313.1|7312144_7312315_+|50S-ribosomal-protein-L33	unknown	unknown	gnl|CDD|234783
CP035758.1|QBD80306.1|7302852_7303308_-|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
CP035758.1|QBD80310.1|7309068_7309500_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	unknown	unknown	gnl|CDD|367091
CP035758.1|QBD80316.1|7313623_7314046_+|50S-ribosomal-protein-L11	unknown	unknown	gnl|CDD|234661
CP035758.1|QBD80317.1|7314118_7314826_+|50S-ribosomal-protein-L1	unknown	unknown	gnl|CDD|180071
CP035758.1|QBD80312.1|7310824_7312030_+|elongation-factor-Tu	unknown	unknown	gnl|CDD|234596
CP035758.1|QBD80305.1|7301395_7302505_-|hypothetical-protein	unknown	unknown	gnl|CDD|370676
CP035758.1|QBD83652.1|7303446_7304415_-|amidohydrolase	unknown	unknown	gnl|CDD|225070
CP035758.1|QBD80315.1|7312818_7313391_+|transcription-termination/antitermination-protein-NusG	unknown	unknown	gnl|CDD|180161
CP035758.1|QBD80314.1|7312384_7312786_+|preprotein-translocase-subunit-SecE	unknown	unknown	gnl|CDD|376355
CP035758.1|QBD80303.1|7299401_7300484_-|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|187652
CP035758.1|QBD80307.1|7304557_7305391_-|MerR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|133382
CP035758.1|QBD80301.1|7296956_7297619_+|esterase	unknown	unknown	gnl|CDD|366286

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD80318.1|7314950_7315694_+|50S-ribosomal-protein-L10	gnl|CDD|234632	PRK00099, rplJ, 50S ribosomal protein L10; Reviewed.	8.51252e-48
CP035758.1|QBD80313.1|7312144_7312315_+|50S-ribosomal-protein-L33	gnl|CDD|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	2.80171e-17
CP035758.1|QBD80302.1|7298895_7299285_-|PPOX-class-F420-dependent-oxidoreductase	gnl|CDD|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	6.53253e-38
CP035758.1|QBD80319.1|7315724_7316108_+|50S-ribosomal-protein-L7/L12	gnl|CDD|234671	PRK00157, rplL, 50S ribosomal protein L7/L12; Reviewed.	1.77691e-39
CP035758.1|QBD80304.1|7300878_7301271_+|transcriptional-regulator	gnl|CDD|224647	COG1733, COG1733, Predicted transcriptional regulators [Transcription].	4.98106e-38
CP035758.1|QBD80308.1|7306478_7307525_+|ribosome-small-subunit-dependent-GTPase-A	gnl|CDD|234631	PRK00098, PRK00098, GTPase RsgA; Reviewed.	1.68878e-108
CP035758.1|QBD80306.1|7302852_7303308_-|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.61185e-13
CP035758.1|QBD80310.1|7309068_7309500_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin	gnl|CDD|367091	pfam02452, PemK_toxin, PemK-like, MazF-like toxin of type II toxin-antitoxin system. PemK is a growth inhibitor in E. coli known to bind to the promoter region of the Pem operon, auto-regulating synthesis. This family represents the toxin molecule of a typical bacterial toxin-antitoxin system pairing. The family includes a number of different toxins, such as MazF, Kid, PemK, ChpA, ChpB and ChpAK.	3.0747e-09
CP035758.1|QBD80316.1|7313623_7314046_+|50S-ribosomal-protein-L11	gnl|CDD|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	8.18719e-88
CP035758.1|QBD80317.1|7314118_7314826_+|50S-ribosomal-protein-L1	gnl|CDD|180071	PRK05424, rplA, 50S ribosomal protein L1; Validated.	1.00598e-131
CP035758.1|QBD80312.1|7310824_7312030_+|elongation-factor-Tu	gnl|CDD|234596	PRK00049, PRK00049, elongation factor Tu; Reviewed.	0
CP035758.1|QBD80305.1|7301395_7302505_-|hypothetical-protein	gnl|CDD|370676	pfam09770, PAT1, Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.	0.000303303
CP035758.1|QBD83652.1|7303446_7304415_-|amidohydrolase	gnl|CDD|225070	COG2159, COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only].	1.0037e-45
CP035758.1|QBD80315.1|7312818_7313391_+|transcription-termination/antitermination-protein-NusG	gnl|CDD|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	9.32665e-90
CP035758.1|QBD80314.1|7312384_7312786_+|preprotein-translocase-subunit-SecE	gnl|CDD|376355	pfam00584, SecE, SecE/Sec61-gamma subunits of protein translocation complex. SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates protein from the cytoplasm to the ER. Archaea have a similar complex.	7.02747e-13
CP035758.1|QBD80303.1|7299401_7300484_-|SDR-family-oxidoreductase	gnl|CDD|187652	cd08948, 5beta-POR_like_SDR_a, progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs. 5beta-POR catalyzes the reduction of progesterone to 5beta-pregnane-3,20-dione in Digitalis plants. This subgroup of atypical-extended SDRs, shares the structure of an extended SDR, but has a different glycine-rich nucleotide binding motif (GXXGXXG) and lacks the YXXXK active site motif of classical and extended SDRs. Tyr-179 and Lys 147 are present in the active site, but not in the usual SDR configuration. Given these differences, it has been proposed that this subfamily represents a new SDR class. Other atypical SDRs include biliverdin IX beta reductase (BVR-B,aka flavin reductase), NMRa (a negative transcriptional regulator of various fungi), phenylcoumaran benzylic ether and pinoresinol-lariciresinol reductases, phenylpropene synthases, eugenol synthase, triphenylmethane reductase, isoflavone reductases, and others. SDRs are a functionally diverse family of oxidoreductases that have a single domain with a structurally conserved Rossmann fold, an NAD(P)(H)-binding region, and a structurally diverse C-terminal region. Sequence identity between different SDR enzymes is typically in the 15-30% range; they catalyze a wide range of activities including the metabolism of steroids, cofactors, carbohydrates, lipids, aromatic compounds, and amino acids, and act in redox sensing. Classical SDRs have an TGXXX[AG]XG cofactor binding motif and a YXXXK active site motif, with the Tyr residue of the active site motif serving as a critical catalytic residue (Tyr-151, human 15-hydroxyprostaglandin dehydrogenase numbering). In addition to the Tyr and Lys, there is often an upstream Ser and/or an Asn, contributing to the active site; while substrate binding is in the C-terminal region, which determines specificity. The standard reaction mechanism is a 4-pro-S hydride transfer and proton relay involving the conserved Tyr and Lys, a water molecule stabilized by Asn, and nicotinamide. In addition to the Rossmann fold core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids, and typically have a TGXXGXXG cofactor binding motif. Complex (multidomain) SDRs such as ketoreductase domains of fatty acid synthase have a GGXGXXG NAD(P)-binding motif and an altered active site motif (YXXXN). Fungal type ketoacyl reductases have a TGXXXGX(1-2)G NAD(P)-binding motif.	1.14251e-133
CP035758.1|QBD80307.1|7304557_7305391_-|MerR-family-transcriptional-regulator	gnl|CDD|133382	cd01107, HTH_BmrR, Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator. Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BmrR and YdfL of Bacillus subtilis, and related proteins; N-terminal domain. Bmr is a membrane protein which causes the efflux of a variety of toxic substances and antibiotics. BmrR is comprised of two distinct domains that harbor a regulatory (effector-binding) site and an active (DNA-binding) site. The conserved N-terminal domain contains a winged HTH motif that mediates DNA binding, while the C-terminal domain binds coactivating, toxic compounds. BmrR shares the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements.	1.06482e-38
CP035758.1|QBD80301.1|7296956_7297619_+|esterase	gnl|CDD|366286	pfam00756, Esterase, Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.	1.91072e-10

Protein sequences

>CP035758.1|QBD80308.1|7306478_7307525_+|ribosome-small-subunit-dependent-GTPase-A
MLINDPAILTGIVLSGTHGIYDVHTDNGILRCTLRGKLRKAFARTQSAKSISKTRPRPDTLYATSSYQRRERIEKRDSSETPVPPRLSVGDYVKLRQLDNSNGLIEEILPRQSELTRKDTASTARKSIQQTMLANLDQVVIVFATAEPEPHFGLLDRYLTICEAAELKALICLNKVDLPHGVSVEEAAQLYTSLGYTVIWSSTQTNEGIETLRLLLKDHTSLFTGPSGVGKSSLVNALEPGMAIRTGLVSSATGKGRHTTTGSQLYPLSTGGWLADSAGIRALVAWDIPAEELAACFTEFRPYLDECEYSDCAHIDEEGCAIIQAVTDGVISERRYKSYVRMYTEEER
>CP035758.1|QBD80307.1|7304557_7305391_-|MerR-family-transcriptional-regulator
MIKIRDFAEIAQVATSTLRYYDEIGLFKPVYVDPDTGYRFYAIEQLLRLNRILALKDLGLELGQIVQLLDEEVSIEALQGMLRLKQARLQQHIQDEQEQLVRIEARLRYIAQEGHRLAREVVLKEVKPLTVIAGYTHVAGFLPNRQYANALLAMLKQNAICPAGPVLYIYHEGTSETIDFNVEVAVPVEPGSVNLAKLSPDWNRRVVLRELPAVSIMASLIHHGNPHGSVEAYQALGVWIQTNGYTVTGPCRKLSLRWSGELDDYLTEIQYPIEMKR
>CP035758.1|QBD83652.1|7303446_7304415_-|amidohydrolase
MRVIALEEHFVSPAFLDGPGRYIKEQARTPASSQFLAWLSDLDTGRIAAMDTAGITVQVLSLGSPGVEQLDAAEAISVSRETNDYLAAAIRRHPERFVGLAALPTAAPAVAADELERAVRELGFRGALINGHTRGRYLDDQFFWPILERAETLQVPLYLHPTPPPQSIVETSYAGFAPEVTARLSTYAWGWHVETAIHVLRLVLGGVFDRYPRLQFVVGHMGEGLSFMLPRIERYLPAEVTKLQRSIGAYLRENLYYTFSGFTWTSMFLNLLLELGSERIMFSVDYPNASMVETRDFLERLPVRPSDKELIAHGNAERLLRL
>CP035758.1|QBD80306.1|7302852_7303308_-|GNAT-family-N-acetyltransferase
MSDINIRLARPDEQETVSACVNIAFTKYVERMGRKPVPMLADYAELIARGVVYVALLQDVVVGVLVMMPDAEGLFIDTLALHPEYQGHGLGRRLLQFAEQYARAANLGRLHLYTNKLMTENLSFYPHLGFVEVEHKAEHGYQRVFFEKVLP
>CP035758.1|QBD80305.1|7301395_7302505_-|hypothetical-protein
MQQPPNPNQPSQPWSNQPWDDQTQAQIPYQGAGQYPPYQQPFYGSQQSPTYISPGQFANTPPPPPPPHIGPGQPQPYSRPYGGLILATLILVYVAAWIIGFAGMSGITTSLILGLIVSLLIIDWRGFTSLQDLIKWKQMRGSKRFWLGLLFICTFYIMLGIYLCRACIPTQPATVAYKPRSRGRSAVGLVVGTVLTMFFMLIAASNPSAAKTSAGQTVVQGTVQIQSSPTATRQKSAVITPTTSISVSPTAVPTIVATSVPASTPTIEPTQVPTVVPTQPPMPTPTVAPTQPPAHTGVNGNPWGYDFNSSGNKISDPPAEFCNYFSCIKSFWNGTGYVIECQDNTFSKSGGNQGSCSHHGGDKATLFSH
>CP035758.1|QBD80304.1|7300878_7301271_+|transcriptional-regulator
MERTSTAPSPHSVLIEHCPSRQVLDLIADKWTALIFALLERHPTRFNEMQRAIGGISHKMLTQTLRSLEQRGIVQRKITLTNPPAVEYSLSPLGTTLIPLMAALRQWAEEHMEEVEQIRQAYIEQEDKTD
>CP035758.1|QBD80303.1|7299401_7300484_-|SDR-family-oxidoreductase
MNARDARANEKTRKVALVVGAQGVIGRNLIEYLSTLDDWDIIGLSRRHGEATERVRYVTVDLLNREDTHAKLGKLTQVTHIFFVAYQDRPSWAELVEPNLTMLVNVVEAMEPVAPNLQHISLMQGYKVYGAHLGPFKTPARESDAGHMPPEFMVDQQNFLEQRQKGKAWSWSAIRPSVVAGFALGNPLNLAMVIAIYASISKELGLPLRFPGKLGAYDKLLEMTDAGLLARAIVWAATNERSANQAFNINNGDLFRWSEMWPKIARYFDLEVAPPLQMSLNVVMADKEPLWNSMIEKYGLENIPYEDVSSWNFGDFVFSWDYDMFADGSKARRFGFHEYVDTEAMFKDIFDDFRRRKIIP
>CP035758.1|QBD80302.1|7298895_7299285_-|PPOX-class-F420-dependent-oxidoreductase
MADLQNPKVQKILHSKAFAHLATIGADGAPQSSPMWFLWDGEHIKFTHTTNRQKYRNIQHDPRVAISIRDLDDPYAYAEFRGIVERIEEDPTGAFYDTLAEHYGSPARYRGDPRVILYVKVQRVVGQNL
>CP035758.1|QBD80301.1|7296956_7297619_+|esterase
MNDRAIAGAFVPETFDYDGGRPVTVYVPPDPPEAVVFAGDGQGISQWGRFLEAADVPPTMIVGVHGLTDEKLRLQEYSPVFDAERFTAHEKFFVEDVRRWTESRFGVTLPTARTAVLGTSAGGELALALGLRHPDVYGAIFCASPGAGYKPTEVMPSRIPRTYLVAGTQEPFFLENATRWATALRNSGANVVLKERVGSHGGAFWQKEFPLMVAWAFGRE
>CP035758.1|QBD80300.1|7296534_7296696_+|hypothetical-protein
MLKEEKTLAQIASEYEVHPTQLKNWRSIALEGMASLFENQDSTAELKAAHEQQ
>CP035758.1|QBD80310.1|7309068_7309500_-|type-II-toxin-antitoxin-system-PemK/MazF-family-toxin
MPHPPDLAPDALTYQTPVQFGMVYWVNFGYPSLPPGIEEKRILDWHPALVVSGDPFCRHAGAVNVVALTSYRGKLRPYHHLLLKRDYPLLDTDSLVKTELMYPVLRTLLADQFAICRLNDADLRAIMAKVANSLAITMFYSLH
>CP035758.1|QBD80311.1|7309534_7309762_-|hypothetical-protein
MATNCDFSRSSLLSEQYQRDMELIAVALQEESQDERDERLSLVARAWSLTSACFHKQLEPAEAPAYTASVAFARP
>CP035758.1|QBD80312.1|7310824_7312030_+|elongation-factor-Tu
MAKKKFERTKPHVNVGTIGHIDHGKTTLTAAITKVLASAQLAKYAAFDSIDKAPEERERGITIAIAHLEYETEKRHYAHVDCPGHADYIKNMITGAAQMDGAILVVSAPDGPMPQTREHILLAHQVNVPAMVVFLNKVDMLEDEELLELVELEVRELLSKNSFPGDDVPVVRGSALKALESKGDLSRNDPAAKCIWELMDQVDSYIPTPERPLDKPFLMPVEDVFGIKGRGTVATGRIERGSVKTGENVEIVGMKEESRTVVVTGVEMFQKTLDEGLAGDNVGCLLRGVERTDIERGQVLAKPGSIKPHKTFLAQVYVLSKEEGGRHTPFFNGYRPQFYVRTTDVTGAIKLPEGVEMVMPGDNIEMTVELIQPVAMEEGVSFAIREGGRTVGAGVCTKVIA
>CP035758.1|QBD80313.1|7312144_7312315_+|50S-ribosomal-protein-L33
MASKGKENRIVVTLACTTCKSRNYTTSKNKKNNPERLEFRKFCNTCRVHAPHRETK
>CP035758.1|QBD80314.1|7312384_7312786_+|preprotein-translocase-subunit-SecE
MASKMAEKKKNASRSQVADVKARNSEKEQSTRSAKAASRDERKESSKRDNRSKQRSSSAKAPSPLVLRFRNSAIGRFIIEAYYELRHKVTWPTFEEARNMTIAVIALSAVIGGILAIEDFGLYHLVLLISGGK
>CP035758.1|QBD80315.1|7312818_7313391_+|transcription-termination/antitermination-protein-NusG
MVTEHTSENGQTNQPERAWYAIHTYSGYENKVKSHLEARIASMDMRNKIFRVIVPMEEEVEIKQGQRRTVQRKVFPGYVLVEMIMSDEAWYVVRNTPGVTSFVGSGTRPVPLQEHEIKTILKQVTKESDKPKAKVSFSKGQNVRVIDGPFTEFIGTVSDINLDRNKVTVLVSFFGRETPVVLDFLQVEKI
>CP035758.1|QBD80316.1|7313623_7314046_+|50S-ribosomal-protein-L11
MAKRIKAVVRLEIPAGKANPAKPVGTALGPHGVNIMMFCKEYNARTADQAGMIIPAEITIYEDRSFTFITKTPPVAFLLRTAAGIEKGSPTPNKAKVGTISHAKLREIAELKLKDLNATDVEAAERIVAGTARSMGVDIE
>CP035758.1|QBD80317.1|7314118_7314826_+|50S-ribosomal-protein-L1
MKNEHGKKYLEAAKLVDPAKLYEPQEAVSLLKKINYVKFDPTIEIHMKLGVDPRHADQMVRGVAMLPAGTGKEVKVLVFTQGEKVAEAESAGADFVGLDDLIKQIEGDWLGFDVAIATPDVMGKVGRLGKKLGPRGLMPSPKAGTITFDLAKTIREVKAGRVEFKVDRTALLHIPAGKLSFSEDALMSNISSVIDAVVRARPSGAKGTYVKSVVLTSTMSPSLRLDVPTALALKP
>CP035758.1|QBD80318.1|7314950_7315694_+|50S-ribosomal-protein-L10
MPQAYKRRKRRLAEGSHKALTLCCAIFREQRHEQQNDFSRPSVVEIEGLFLYHLAFRSDYLSSERREAYMPTQAKAEKIEELTDKLSRATVAILMQTQGLSVKDMTELRSKMRAAKLELQVTKNTLLRIASERNNMTEVDKGIFNGQTTVAFGYEDEVAAAKAVADYVRTSKVAQLKSAILGGRTLNANQVEDLGKIPGGKDSIKAQVVGTVQGPMSTTYSLLTAPLRDLCYVLQARADQLGESKAE
>CP035758.1|QBD80319.1|7315724_7316108_+|50S-ribosomal-protein-L7/L12
MSVANIIEEIEKLNVLELVELSKTLQEKWGVSAAPVAAGPAVAAAAAPTEAAAPVEEKTEFDAVLTDVGSNKIQVIKVVRELTGLGLKEAKAVVDEAPKPVKEGVSKEEAEKVVAKLAEVGAKVEIK

Crispr_ID: CP035758_26

• CRISPR_ID: CP035758_26
• CRISPR_location: 7354601-7354688
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP035758_26

Consensus_repeat	Method
TGTGGATAACTTATCCACATTTA	CRISPRCasFinder

spacers of CP035758_26

>26.1|7354624|42|CP035758|CRISPRCasFinder
TTACCGGCCGGTGGATAAGCCGCCTAAGTTATCCACCGGAGC

CRISPR arrays and Neighbor proteins around CP035758_26

CRISPR arrays

The CRISPR arrays of CP035758_26

>merge|CP035758|26|7354601-7354688|CRISPRCasFinder
TGTGGATAACTTATCCACATTTATTACCGGCCGGTGGATAAGCCGCCTAAGTTATCCACCGGAGCTGTGGATAACTTATCCACATTGA

>CP035758|26|23|7354601-7354688|CRISPRCasFinder
TGTGGATAACTTATCCACATTTA	TTACCGGCCGGTGGATAAGCCGCCTAAGTTATCCACCGGAGC
TGTGGATAACTTATCCACATTGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD80354.1|7366964_7368851_-|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl|CDD|224055
CP035758.1|QBD80346.1|7355518_7357618_+|DNA-primase	unknown	unknown	gnl|CDD|235551
CP035758.1|QBD80338.1|7340961_7341732_+|thymidylate-kinase	unknown	unknown	gnl|CDD|223203
CP035758.1|QBD83654.1|7364521_7365745_+|sulfite-exporter-TauE/SafE-family-protein	unknown	unknown	gnl|CDD|376667
CP035758.1|QBD80350.1|7361194_7362208_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|223135
CP035758.1|QBD80343.1|7349598_7350375_-|transporter-substrate-binding-domain-containing-protein	unknown	unknown	gnl|CDD|270225
CP035758.1|QBD80336.1|7339504_7339906_+|hypothetical-protein	unknown	unknown	gnl|CDD|224469
CP035758.1|QBD80337.1|7340200_7340965_+|thymidylate-kinase	unknown	unknown	gnl|CDD|223203
CP035758.1|QBD80349.1|7359988_7361185_-|phosphoglycerate-kinase	unknown	unknown	gnl|CDD|376298
CP035758.1|QBD80352.1|7365958_7366558_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|131997
CP035758.1|QBD80340.1|7343164_7346986_-|hypothetical-protein	unknown	unknown	gnl|CDD|223496
CP035758.1|QBD80348.1|7359114_7359909_-|triose-phosphate-isomerase	unknown	unknown	gnl|CDD|234589
CP035758.1|QBD80344.1|7350371_7350602_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD80347.1|7357760_7359035_+|RNA-polymerase-sigma-factor-RpoD	unknown	unknown	gnl|CDD|236413
CP035758.1|QBD80339.1|7341808_7342138_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD80342.1|7348887_7349604_+|HD-GYP-domain-containing-protein	unknown	unknown	gnl|CDD|225116
CP035758.1|QBD80345.1|7350879_7353396_+|hypothetical-protein	unknown	unknown	gnl|CDD|283786
CP035758.1|QBD80341.1|7347037_7348345_-|hypothetical-protein	unknown	unknown	gnl|CDD|277319
CP035758.1|QBD80353.1|7366547_7366742_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD80351.1|7362530_7363967_-|pyridoxal-phosphate-dependent-aminotransferase	unknown	unknown	gnl|CDD|99734

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD80346.1|7355518_7357618_+|DNA-primase	gnl|CDD|235551	PRK05667, dnaG, DNA primase; Validated.	4.23756e-163
CP035758.1|QBD80338.1|7340961_7341732_+|thymidylate-kinase	gnl|CDD|223203	COG0125, Tmk, Thymidylate kinase [Nucleotide transport and metabolism].	5.90385e-31
CP035758.1|QBD83654.1|7364521_7365745_+|sulfite-exporter-TauE/SafE-family-protein	gnl|CDD|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	3.45574e-27
CP035758.1|QBD80350.1|7361194_7362208_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl|CDD|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	0
CP035758.1|QBD80343.1|7349598_7350375_-|transporter-substrate-binding-domain-containing-protein	gnl|CDD|270225	cd01004, PBP2_MidA_like, Mimosine binding domain of ABC-type transporter MidA and similar proteins; the type 2 periplasmic binding protein fold. This subgroup includes the periplasmic binding component of ABC transporter involved in uptake of mimosine MidA and its similar proteins. This periplasmic binding domain belongs to the type 2 periplasmic-binding fold protein (PBP2) superfamily, whose members are involved in chemotaxis and uptake of nutrients and other small molecules from the extracellular space as a primary receptor. PBP2 typically comprises of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two receptor cytoplasmically-located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	3.302e-55
CP035758.1|QBD80336.1|7339504_7339906_+|hypothetical-protein	gnl|CDD|224469	COG1552, RPL40A, Ribosomal protein L40E [Translation, ribosomal structure and biogenesis].	0.00643691
CP035758.1|QBD80337.1|7340200_7340965_+|thymidylate-kinase	gnl|CDD|223203	COG0125, Tmk, Thymidylate kinase [Nucleotide transport and metabolism].	6.72941e-32
CP035758.1|QBD80349.1|7359988_7361185_-|phosphoglycerate-kinase	gnl|CDD|376298	pfam00162, PGK, Phosphoglycerate kinase.	0
CP035758.1|QBD80352.1|7365958_7366558_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|131997	TIGR02952, RNA_polymerase_sigma-70_factor_ECF_subfamily, RNA polymerase sigma-70 factor, TIGR02952 family. This group of sigma factors are members of the sigma-70 family (TIGR02937). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is found in a limited number of Gram-positive bacterial lineages.	2.37719e-17
CP035758.1|QBD80340.1|7343164_7346986_-|hypothetical-protein	gnl|CDD|223496	COG0419, SbcC, ATPase involved in DNA repair [DNA replication, recombination, and repair].	3.81223e-25
CP035758.1|QBD80348.1|7359114_7359909_-|triose-phosphate-isomerase	gnl|CDD|234589	PRK00042, tpiA, triosephosphate isomerase; Provisional.	6.02644e-126
CP035758.1|QBD80354.1|7366964_7368851_-|ABC-transporter-ATP-binding-protein	gnl|CDD|224055	COG1132, MdlB, ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms].	0
CP035758.1|QBD80347.1|7357760_7359035_+|RNA-polymerase-sigma-factor-RpoD	gnl|CDD|236413	PRK09210, PRK09210, RNA polymerase sigma factor RpoD; Validated.	0
CP035758.1|QBD80342.1|7348887_7349604_+|HD-GYP-domain-containing-protein	gnl|CDD|225116	COG2206, COG2206, c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms].	1.49537e-59
CP035758.1|QBD80345.1|7350879_7353396_+|hypothetical-protein	gnl|CDD|283786	pfam06202, GDE_C, Amylo-alpha-1,6-glucosidase. This family includes human glycogen branching enzyme AGL. This enzyme contains a number of distinct catalytic activities. It has been shown for the yeast homolog GDB1 that mutations in this region disrupt the enzymes Amylo-alpha-1,6-glucosidase (EC:3.2.1.33).	1.43536e-95
CP035758.1|QBD80341.1|7347037_7348345_-|hypothetical-protein	gnl|CDD|277319	cd00840, MPP_Mre11_N, Mre11 nuclease, N-terminal metallophosphatase domain. Mre11 (also known as SbcD in Escherichia coli) is a subunit of the MRX protein complex. This complex includes: Mre11, Rad50, and Xrs2/Nbs1, and plays a vital role in several nuclear processes including DNA double-strand break repair, telomere length maintenance, cell cycle checkpoint control, and meiotic recombination, in eukaryotes. During double-strand break repair, the MRX complex is required to hold the two ends of a broken chromosome together. In vitro studies show that Mre11 has 3'-5' exonuclease activity on dsDNA templates and endonuclease activity on dsDNA and ssDNA templates. In addition to the N-terminal phosphatase domain, the eukaryotic MRE11 members of this family have a C-terminal DNA binding domain (not included in this alignment model). MRE11-like proteins are found in prokaryotes and archaea was well as in eukaryotes. Mre11 belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	1.03748e-16
CP035758.1|QBD80351.1|7362530_7363967_-|pyridoxal-phosphate-dependent-aminotransferase	gnl|CDD|99734	cd00609, AAT_like, Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.	1.0112e-34

Protein sequences

>CP035758.1|QBD80345.1|7350879_7353396_+|hypothetical-protein
MLCYTMRVYDAKLRTFTQINCPYLVTAHLIEGLGGSGMPITFDRSTCCDLNEIISREWLVTNGLGGYAAGTVAGVLTRMQHGLLVIVPPDTVQPQLLLAKLDEEIAFDQRTYYLGTNEYRDGTLSPAGFVHLESFHLEQGFPVFNYRLGGPHGILLEKRIWMLQGSNTTYIRYRVRRMPSQEETSNYARQGLASRYYDHTSGSGRDMRLSITLLPFAAQRPYNQPQYGNNAWHFLVQPQPGRELIDEDEWSPGIRSSRPRLMTGCTLQASEEARPYHILAIGHPESQVTFIPTGVWYWNFLRRHDARAGLLATDDLYLPGVFRATLWPEEDATLTLVISAEALSSPELRLHQLNLSYEQALEQQKDLLRDALQPQRYFGEGGEAAQAHHLHVLPLTTTSDPYAGGEDFLHQLLQASEHFLTWRKASADRQRKTRHGLFHTPERMPALCSGYFDLEYKTRDALIALPGLLLVTERYDEALKILRELIRHVKGGLLPDHLPVPGQRLSECDYNSADTTLWYIYALDHYLRVTHNYAFLEEAYYILTECINRYMRGTYHGIHVNSTDGLLYAGREGKALTWMDAMANGTPVTPRAGKPVELNALWYHALSLMHEWSQYFTHQSSLRYHTAFYQELLTRNRRSFQERFWYSEGGYLYDVIDGPQGNDASLRPNQLLALSLRYSVLDNQCCESIFEAVTQHLLTPYGLRSLAPHDPAYRGHAGSTREEQQRVLHQGNVWSWLIGPYIEAMLSIKLHASAAPSSDEKTLFQEYLWRKGLQLLEPFKNRFTVGLLSMNEGTFNGDAPFHPTGQYLASASCTGELLRIYDMLARMRSLPLTYTLSR
>CP035758.1|QBD80344.1|7350371_7350602_-|hypothetical-protein
MRFSLFKTRRQLSLLQPRLIGIAMLLCLLLSACSNLGLKLNTPEPTPAVSRIMPHDLLTPGFLTVGNYPNYPPRNR
>CP035758.1|QBD80343.1|7349598_7350375_-|transporter-substrate-binding-domain-containing-protein
MNTSTKEIQGFDIDLINAVAQHLGLKTKIVPEDFHTIIDKLVDQDFDVVISAVSITDELRQKVDFVPYFSGGESLMVRKGNPGQIRSLADLCGLKVGAQNNTLEQNDLKIASKDCQQQHKVAIDMVIVQDQAAVMSLLEEKKVVAVYQDSPVTDYMVKQHPDLFEPGGLVTNANLEGIVVRKGDSLMLSAIQSAFSAVEGDGTYHKLIMKWGLVNEEIQLARTSHSAQITPQLQRNPEPSPGSAAYSSGACWQRRPYL
>CP035758.1|QBD80342.1|7348887_7349604_+|HD-GYP-domain-containing-protein
MAARCTCEVGESVVGATHTEKERETRKVLLSFAKSIQERDIVTYEHSRRVAIYVQRLAWYLGWSRREARDLGLAALVHDLGKTWITNDILNKSEGLSEEEWNKMKRHPVIGARILIGCDVQPFYVEAVLYHHEAWNGHGYPAGLKGEEIPLSARLLTVADVYDVLTSQRPYKTALSQDAARERLLLDSGTSFDPTILQAFVHLLDTVPNFTLPQYNYISAKKEALPPIPRRLFMTTGS
>CP035758.1|QBD80341.1|7347037_7348345_-|hypothetical-protein
MAEDTVEQDAKQDVSTEQAERHEEVVSIVLTSDNHLGYTAFRQHPRKREELLRRLRRAFQQATDFAIEHKVDLFIQAGDLFDTTTPDERDRSFVATRLAQLKQAGVRAFALGGVHDTPGEAQSLLGEAVLAPQISYARLDALHYFPPAPEEELEPVLLDVRDTKLGICALGVLVGQEGDPLAHLQVKESLKDAAIPLLLLHAPIEGLANGSSLLDTRAMVSQESIAGQTLFRYILAGYHHSHYQLHLGQVDVVVAGATQHLDFSTPDHAPGFVYLGLAADGIQWCKHIPVDTLLLQRLTINTKELWSDDSAAAQQLPTEIILEQLRPLCNADTLLQLRLEGELTRGQYHQLDLNQIRRYGEEHCFALAIDDSVLSLLPEQEAVSAETGERFSPREELIALADEWIADAPDEQEKKALQITKEELLRAMDDMKGKR
>CP035758.1|QBD80340.1|7343164_7346986_-|hypothetical-protein
MIILKHLTVERFRLLRELNLHFPQRGSILIQGPNEAGKSALIESIYFALYGEALASAKPSLDDLVLYGATTATVSLTLSVGATEMTITRSLERGKGQKVALNVRRLGMPEEKPIVDLAAANERIIQELGCLDGETVRNACLIEQKGLDRLEKLSGAEREASARKVLGLEKLMRLTEHFKIGADDEKQLHESRERLRLAEMQARIPEVSRKLGKVEAALDALKVAVDLEEISAQELDIAEQEQTLEQIRIRRQEIRNRLSRVQQLKKADATLEEIIAAYEAIAEARHQIPELEKQIAELERREHEELPILEKRVTDLAELTRSFGTLQRMSNDLLAVVDTIKEHEQELRKFGEVKDDLHSVDEQVAHARSRLEQAQQALHDLEERRRAGLPQLEARLQRMRALSERLAALRQQENQYLHRLKDKSLAEQNRAHFSTVQGELQETEQELKLVESEARQTQSQADGLERRWRQLAVRRQIEEWQRLKGLAQGLAEAEQHVRLAYQHQEKLNLAAMEARSASRKYLIIAAISVVLLLGLAAAAFVLFSQNVPIVASIAGILALVMGAIGFLNFQSYGKAREEEKVADQQMQEAINQVGMMVAARETALRMSGDNEALLQVEHEIRSLGGNIPRSLEDAQSYLMQVKDQGESLADLQRQMREKIEEANAARNQVNVTMEAVANLRKERARLEDEYKRGDWAHIEEHLRDDQSTIERMHEEVALLTEQEGLTLPSIGERLQSTASLGFSRSDPISRDNSQAGIPELEAIIESNISATERELATLDGKMDLVTDLSAQVKIHQDALDVLLTRRRAFEERVARFEESNPALKIERAREQQMALREALQALQDSLRQRVRPLGVSFGQAAINHAETVARKQLEELHITLGNRIMLQERHGNYVVQLKELQEALSEYYKQLAKYSNSLGSWIVPLNPFAEALIALRTRCQRELTEAREAEAVKELDTLSEQEGAAKIKIELCQNEIEGAEERISAMLAQRNRPAVKTYTVSEIIAVWPLVGEYTSRDRHGLEEERVTFEEELTQLEEQELELSKQLQTGRAPLDLKQSRAEMDKQERSYETKKRANMLVQGVHDRLMRKMLPRTEYYMQQLLPLLTGGRYHDAHLITQPEQGAASGGPFQISVWEPAASAYVSKSALSGGAADQFSLALRLAFAIASLPRELNAAPGFVVMDEPLSSFDRGRAQALVNVINGEILGQHFEQIILVSQNNAFDPAMFPYHVYLDNGIVEESNLPLVPGLPAVDADEYTDETMLRIPVPMRVTVQ
>CP035758.1|QBD80339.1|7341808_7342138_-|hypothetical-protein
MIPGFHALDLIIFLFIALNLPMLLHCLLNRALSWKQKVLWLLVIGLCHILGALLYFCVVLVGGLGKKKPSLYSTPANEIFSMARQDPPSEEFPLTIYEQPQASYPEDKR
>CP035758.1|QBD80338.1|7340961_7341732_+|thymidylate-kinase
MNFREEDDGREAYRSATIRVAEREDMTDLAFYGIDAIGLRERDEVLPGRLIVIEGTDGVGRTTQLNLLRPWLESSGYAVVDTETTRSVLAGPGLKQAKEGHTLGPITLNLFYATDFVDRFENQMLPALRAGFIVLTDRYVYSLIARALVRGADARWIRSIYGLALKPDAIFYLHIHLHELIPRVLQRGGFDFWESGMDMRLGADLYESFVNYQTRLLAEYEKMIPIYNFQVIDATLPVEQISEQLKLKILPLLPQG
>CP035758.1|QBD80337.1|7340200_7340965_+|thymidylate-kinase
METYGLHQYPGKLFIVEGVDGSGKSTQIALLRQWLISEGYTVFFSEWNSSPLVKKTTSKGKKKQLLTPTTFSLIHATDFADRTEHDIIPPLKAGAIVLADRYIYTAFARDAARGVDRLWLRELYQFAVKPTVAFYYRVPLDVSLKRILTSRNELKYYEAGMDMGLSNDPYESFKLFQQRIVNEYETMVDEFGLTAMDATLPIPEQQRQMRRLVRPHLQGVRRLRASAQNIALSGLIQETHLFNNLAHELKGAER
>CP035758.1|QBD80336.1|7339504_7339906_+|hypothetical-protein
MPSFEPAQNMSLCMRCGRPLPTAGFVCRACRPAALRPIRLHAYDHEQFAEVDELTDVEQIASLPTTPANLSLLLMQHVDAYLARGYILVDRGSEYAILQQKKSGAPAITPPRTEIHILIVDSRNTAIHIYKLI
>CP035758.1|QBD80346.1|7355518_7357618_+|DNA-primase
MASIIDIVKAKIDIVEEIGLVVALQKSGKSLKGLCPFHNERTPSFYVFAESQTWHCFGCNEGGDVFSFVQKQQGLEFREALLYLAEKAGVEVEEHGGPSPEEAREISAAKERLRKLNEDALLWFHQMLLRAKEATEARAYVQSRGISADTVIGFGLGYAPDHWDALTHYLQGQGYSQQELVSGGLARERNSQESEGREGGVYDYFRNRLIFPIRDIRGRVIGFGGRALGDGKPKYLNSPQTLLFEKNSVLYAIDMAKDAIKDAGQVVIVEGYVDAVIAHQYGTKQTVACIGSAITEKHIQQLKKMTRQVTLALDPDAAGSAATELGIQEALKTFDRTVVPVPLAAERTERQRSGQGKHKQQVRGIIRLEEQVDAEINVLQLPAGEDPDEVIKRDFSAWLYAVTHPLPLVDYYFVVKTAELNLREPAGKTEAARRLLPVIGMISDRIKRDAYIRKLAGMISIDERSLYEELQKVLKGQKANGVTAAFSAPMGQQAAGKSGPLGGWNAAAQSVKSEVSAGSKDGEKEAQSALEGSGQGPSIRLDRNRDNRLQWEDYLIGLLLQNPGLSQNVCGIINDGDFAGTDTRELYRILNSVYQQRASSPSHQPFEQHVPSALLATVARAQKCVESRYPRDGEPVKEAIQCATRLKRTRLLQLNTELKYLIHEAAEAGDSVAVRQFLLQVSQIERQLRTINTAMRLHG
>CP035758.1|QBD80347.1|7357760_7359035_+|RNA-polymerase-sigma-factor-RpoD
MVNRDQEVIDLVHNGHVSTEPLRDVFTIEPFDESMLNDTENVFELDTVGHAHATTEGSLVVTLDENELDLFKLQDEEPMDALDPTKEPPADWEPGPEDVVDVDADILADPKWEDLQDGFGIVVADLESSLDDPVRMYLREIGRVPLLTAEEEVRLAQLMERGKQERLRAERLKVPPMRRYIEEGEEAQRRLTEANLRLVVSVAKKYIGRGMNLLDLIQEGNIGLIRAVEKFDYNKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINRLIRISRRLLQDLGREPTSEEIAEQMEISAEKVREIIKVSQEPVSLETPIGEEDDSHLGDFIEDHTALAPADAASHQLLKEQVEDVLDSLTERERKVLQLRFGLDDGRSRTLEEVGKEFHVTRERIRQIEAKALRKLRHPSRSRKLKDYLD
>CP035758.1|QBD80348.1|7359114_7359909_-|triose-phosphate-isomerase
MTAARTAIIAGNWKMNYGPQKASSFSMEIIPRLGPLLRSYQEIMCILCPPAISLCSVREVLDAFPTPRLELGAQNMYFEEQGAFTGELSPSMVSEMCSTVILGHSERRTYFGESDELVNKKALAALKHGLRPIVCIGETLEQHEAGKTQEVIRRQVQHSLANFAPQQAREVVIAYEPIWAIGTGKAATGANAGQVTHLIRQLYREMYGQEAAEALRILYGGSVTSDNTSEFMAQEDIDGALVGGASLKPDFVEIVHKTIETMQS
>CP035758.1|QBD80349.1|7359988_7361185_-|phosphoglycerate-kinase
MNKQTIRDIDVAGKRVLLRVDFNVPLDAEQHITDDTRITAALPTIEYLLSKGAAVVLMSHLGRPDGKAVEKLRMAPVARRLSELLHRPVQTATDSVGPEVEAQARALQPGQVLLLENLRFHKEEEKNNQDFARQLAALGDLYVNDAFGTAHRAHASTEGATHYLPGVAGFLMEKEINFLGSALENPQRPFAAIVGGAKVSDKIAVLERLISIADIILIGGGMANTFLKAEGKEIGDSLYEESKVGEAGELLKKAQQRGITLQLPGDVVIADRFAADADHKVVASDKVPAGWRILDIGPATVKSFRAALEPARTIVWNGTLGVAEMPAFAKGTKAVIEILAERTKAGATTIIGGGDSAAAVEQAQAGDQMTHVSTGGGASLEFLEGRTLPGVAALQDKK
>CP035758.1|QBD80350.1|7361194_7362208_-|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MTIRVGINGFGRIGRQSLKAMLERHPEDIEVVAVNDLTDTKTNAHLLKYDSTYGRFPGEVEATPDSLIVNGRTIKVISQRDPAQIPWGDLGVQLVIESTGLFTDAEKASAHLRGGAKKVIISAPAKGEDLTIVLGVNDSMYDPAKHHIVSNASCTTNCLAPTAKVLNDTFGIEHGLMNTIHSYTNDQRILDQVHKDLRRARTAGANIIPTTTGAARALALVIPELKGRFDGMSLRVPTVTVSIVDFVATTRKEVSKEAVNQAFKEAAAGPLKGILEYTEEPLVSSDFRGDSHSSIVDGLSTMVLGGNMVKVLAWYDNEWGYSSRVADLADFIGKKGL
>CP035758.1|QBD80351.1|7362530_7363967_-|pyridoxal-phosphate-dependent-aminotransferase
MITHDSSVNSPTTSLQEQQTLLRQLRSELLRHYRPLLLSGPGPIRVMARIVAELEQECRKRNIAPEVQRTEIVNRTIGDVNLRLVTECEGEPGGPSDYRLLADELGIALPGEQLHDYTATGEAYLWLRNQMMECERLLLSNHFDPRIYDIYGVGNPVLRSWLVQEMQKWSIQVSVNQLYLSLGAMDGIDKVLRGMAFHLRQQSDESIGILFPQPGFNVPEWQARSYGYHLHGYPTSPEQRFKLTPHQLEQILQSWPDIRLIYLTVTNNPTTFAYTADELNALHAVLRRYWEQGRTLYILADLAYIGTGKPEEDLARMATFTAPDVLQHTIFVSSFSKNFTLTGERFGWVTFGDPAIATAIVASWTNSMASLPGEWQIRYMAYYRLLQERPWLNEKLRAFYRYRRKRLIAQLERIKAEQGLFAEVYIDDDATVYNWSRLQSEEDAFSLFEKTGIAGVPGSGFSYTDEYIRFSIGVIPIE
>CP035758.1|QBD83654.1|7364521_7365745_+|sulfite-exporter-TauE/SafE-family-protein
MLKGIVTVLQIGVLSSALLILLGLCLQPFRPGGFSAERLVTFPQTLNQVWAEISSYFGPQAVITLGLLLLVTTPVLRVGVSLLGFARERNRKFVVITSLVLLILLLSLLLVSQGQRAGYVSDIHHLHFSFLVLALIFAGSICAGLLGALVGLGGGVLIVPLLTLVFGLPIHFAIGASIISVIATSSGAAVAYVRDQVTNVKLGMFLELATTTGAVSGAFLAGLLAPATLSIVFGVILLLSSLPILFKLGEEIPKDVQNDRLASWLDLAGSYPDRRSGRTISYHVTRTPIGLAMMYVAGVISGLLGIGSGEFKVLALDTLMHLPMKVSSTTSNFMIGVTAAASAGIYFSRGDIPPLLAGPVALGILLGALLGARLLMHMSNKALRLVFLPVIALAALEMVLHGLGLGL
>CP035758.1|QBD80352.1|7365958_7366558_+|sigma-70-family-RNA-polymerase-sigma-factor
MRRFTLTGNVRRHAAGPGVRTENEVSALHDERVHAAAFKELFKRYLGRVYRYLRVRVACEEEAVRLTHVVFLRALEALPQYQPLRGSFVAWLVSVARRVVEEPGARRGGVRGVSDALPVLLHPEVRYGRQFATLPQEAIARLGLLISRLSQPERDLLALYFAAELNVLEIAQVLERRPEAVKKQLGSLLLAIKERYYAV
>CP035758.1|QBD80353.1|7366547_7366742_+|hypothetical-protein
MQSRPAEEICTELDMQADARLLQLIHDLAMAYGEPEPALELKQAWELLPASHRLSGSLDDTPLS
>CP035758.1|QBD80354.1|7366964_7368851_-|ABC-transporter-ATP-binding-protein
MSDARAKDQQNRGGFFGRGGPVGGLIMPVQKAKDFKGTLKRLASYLLPQKYALLAVIITAVISTIFTIVSPKILGDATTIIFQGLMQKIKGVPGAGVDFSAIMHILIILGILYVISAIFNFIQQYIMASVAQKTTYELRKQVDEKLTRLPLKFFDSRTHGEIMSRAVNDMDNISSTLQQSLTQLIMSIVTLVGVVVMMLSINLLLTIVVLLTLPLSLFVTTVIAKRSQGYFMQQQSSLGELNGHVEEMFTGHKIVKAFGHEGKAVARFDELNGTLYDAGWKAQFVSGIIMPLMMFIGNIGYVLVSIIGCLLVTQRAIQIGDVQAFIQYARQFSQPITQLANIANIIQSTVASAERVFELLDEEEEIPDPATAKIIEAPQGDVQFEHVKFGYKDDAILIEDMNINVKSGQMIAIVGPTGAGKTTLVNLLMRFYELNGGKILIDGVETTQLRRGDLRRMFGMVLQDTWLFSGTIRENIAYGRAGATEEEIIQAATAAHADHFIRTLPAGYDTVLNEEASNISQGQKQLLTIARAILADPAVMILDEATSSVDTRTEVFIQEAMNELTKGRTSFVIAHRLSTIRNADLILVMNHGSIIEQGTHSGLLAKGGFYADLYNSQFTSSVLQENAM

Crispr_ID: CP035758_27

• CRISPR_ID: CP035758_27
• CRISPR_location: 7967871-7967968
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 1 spacers

Consensus repeat of CP035758_27

Consensus_repeat	Method
GGCTGCTGTGGATACTGCGGTTG	CRISPRCasFinder

spacers of CP035758_27

>27.1|7967894|52|CP035758|CRISPRCasFinder
CGGGTAAGCTGGATATTGCTGCTGCCCATATGGATTCGCCTGTTGTGGGTAT

CRISPR arrays and Neighbor proteins around CP035758_27

CRISPR arrays

The CRISPR arrays of CP035758_27

>merge|CP035758|27|7967871-7967968|CRISPRCasFinder
GGCTGCTGTGGATACTGCGGTTGCGGGTAAGCTGGATATTGCTGCTGCCCATATGGATTCGCCTGTTGTGGGTATGGTTGCTGTGGATACTGCGGTTG

>CP035758|27|24|7967871-7967968|CRISPRCasFinder
GGCTGCTGTGGATACTGCGGTTG	CGGGTAAGCTGGATATTGCTGCTGCCCATATGGATTCGCCTGTTGTGGGTAT
GGTTGCTGTGGATACTGCGGTTG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD80815.1|7972821_7974384_-|PucR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|377939
CP035758.1|QBD80806.1|7960569_7960947_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD80818.1|7977042_7977747_+|N-acyl-homoserine-lactonase-family-protein	unknown	unknown	gnl|CDD|293815
CP035758.1|QBD80803.1|7958426_7958840_-|peptide-methionine-(R)-S-oxide-reductase	unknown	unknown	gnl|CDD|376583
CP035758.1|QBD80817.1|7975557_7976628_-|DUF917-family-protein	unknown	unknown	gnl|CDD|226065
CP035758.1|QBD80808.1|7962044_7962782_-|DUF1453-family-protein	unknown	unknown	gnl|CDD|377808
CP035758.1|QBD80814.1|7971974_7972643_-|AroM-family-protein	unknown	unknown	gnl|CDD|369307
CP035758.1|QBD80810.1|7965229_7966963_-|hypothetical-protein	unknown	unknown	gnl|CDD|223864
CP035758.1|QBD80819.1|7978228_7979404_-|winged-helix-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|377630
CP035758.1|QBD80821.1|7980084_7980567_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|281995
CP035758.1|QBD80805.1|7959939_7960449_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD80811.1|7967035_7967410_-|nuclear-transport-factor-2-family-protein	unknown	unknown	gnl|CDD|379639
CP035758.1|QBD80807.1|7960967_7962014_-|hypothetical-protein	unknown	unknown	gnl|CDD|372574
CP035758.1|QBD83677.1|7964505_7965126_+|response-regulator-transcription-factor	unknown	unknown	gnl|CDD|225107
CP035758.1|QBD80813.1|7970308_7971934_-|OPT-family-oligopeptide-transporter	unknown	unknown	gnl|CDD|224216
CP035758.1|QBD80812.1|7968564_7970214_+|sigma-70-family-RNA-polymerase-sigma-factor	unknown	unknown	gnl|CDD|274357
CP035758.1|QBD80809.1|7963130_7964450_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
CP035758.1|QBD80820.1|7979400_7979934_-|VOC-family-protein	unknown	unknown	gnl|CDD|319910
CP035758.1|QBD80816.1|7974589_7975549_-|DUF1177-domain-containing-protein	unknown	unknown	gnl|CDD|377684
CP035758.1|QBD80804.1|7959210_7959753_-|DNA-binding-protein	unknown	unknown	gnl|CDD|378935

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD80815.1|7972821_7974384_-|PucR-family-transcriptional-regulator	gnl|CDD|377939	pfam07905, PucR, Purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.	3.30594e-34
CP035758.1|QBD80811.1|7967035_7967410_-|nuclear-transport-factor-2-family-protein	gnl|CDD|379639	pfam14534, DUF4440, Domain of unknown function (DUF4440).	4.93572e-26
CP035758.1|QBD80818.1|7977042_7977747_+|N-acyl-homoserine-lactonase-family-protein	gnl|CDD|293815	cd07729, AHL_lactonase_MBL-fold, quorum-quenching N-acyl-homoserine lactonase, MBL-fold metallo-hydrolase domain. Acyl Homoserine Lactones (also known as AHLs) are signal molecules which coordinate gene expression in quorum sensing, in many Gram-negative bacteria. Quorum-quenching N-acyl-homoserine lactonase (also known as AHL lactonase, N-acyl-L-homoserine lactone hydrolase, EC 3.1.1.81) catalyzes the hydrolysis and opening of the homoserine lactone rings of AHLs, a reaction that can block quorum sensing. These enzymes belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.	3.65884e-54
CP035758.1|QBD80803.1|7958426_7958840_-|peptide-methionine-(R)-S-oxide-reductase	gnl|CDD|376583	pfam01641, SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterized with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidized methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR, evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain pfam01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family. This family has methionine-R-sulfoxide reductase activity.	2.24863e-82
CP035758.1|QBD80817.1|7975557_7976628_-|DUF917-family-protein	gnl|CDD|226065	COG3535, COG3535, Uncharacterized conserved protein [Function unknown].	2.30739e-73
CP035758.1|QBD80808.1|7962044_7962782_-|DUF1453-family-protein	gnl|CDD|377808	pfam07301, DUF1453, Protein of unknown function (DUF1453). This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown. Members of this family seem to be found exclusively in the Order Bacillales.	0.00127442
CP035758.1|QBD80814.1|7971974_7972643_-|AroM-family-protein	gnl|CDD|369307	pfam07302, AroM, AroM protein. This family consists of several bacterial and archaeal AroM proteins. In Escherichia coli the aroM gene is cotranscribed with aroL. The function of this family is unknown.	2.39071e-89
CP035758.1|QBD80810.1|7965229_7966963_-|hypothetical-protein	gnl|CDD|223864	COG0793, Prc, Periplasmic protease [Cell envelope biogenesis, outer membrane].	3.85476e-16
CP035758.1|QBD80819.1|7978228_7979404_-|winged-helix-DNA-binding-domain-containing-protein	gnl|CDD|377630	pfam06224, HTH_42, Winged helix DNA-binding domain. This family contains two copies of a winged helix domain.	1.23716e-44
CP035758.1|QBD80821.1|7980084_7980567_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl|CDD|281995	pfam04075, F420H2_quin_red, F420H(2)-dependent quinone reductase. This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.	2.62743e-32
CP035758.1|QBD80807.1|7960967_7962014_-|hypothetical-protein	gnl|CDD|372574	pfam13349, DUF4097, Putative adhesin. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.	2.4408e-10
CP035758.1|QBD83677.1|7964505_7965126_+|response-regulator-transcription-factor	gnl|CDD|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	6.35635e-66
CP035758.1|QBD80812.1|7968564_7970214_+|sigma-70-family-RNA-polymerase-sigma-factor	gnl|CDD|274357	TIGR02937, RNA_polymerase_sigma_factor, RNA polymerase sigma factor, sigma-70 family. This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.	5.1942e-31
CP035758.1|QBD80813.1|7970308_7971934_-|OPT-family-oligopeptide-transporter	gnl|CDD|224216	COG1297, COG1297, Predicted membrane protein [Function unknown].	3.03985e-59
CP035758.1|QBD80809.1|7963130_7964450_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	1.05444e-39
CP035758.1|QBD80820.1|7979400_7979934_-|VOC-family-protein	gnl|CDD|319910	cd07246, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	9.89193e-40
CP035758.1|QBD80816.1|7974589_7975549_-|DUF1177-domain-containing-protein	gnl|CDD|377684	pfam06675, DUF1177, Protein of unknown function (DUF1177). This family consists of several hypothetical archaeal and and bacterial proteins of around 300 residues in length. The function of this family is unknown.	0
CP035758.1|QBD80804.1|7959210_7959753_-|DNA-binding-protein	gnl|CDD|378935	pfam12728, HTH_17, Helix-turn-helix domain. This domain is a DNA-binding helix-turn-helix domain.	5.82045e-08

Protein sequences

>CP035758.1|QBD80811.1|7967035_7967410_-|nuclear-transport-factor-2-family-protein
MNHSLEEIVHAEKQLQQAMVNNDVQALERLLHDDLVFIDAEGNVQGKREDIESHASGAMVQTAMEFVEEPIMQFYGESAVVAVKAHVKVQLQGKPLEAFCRYLRIWQFQDERWQIIAGTVRIIS
>CP035758.1|QBD80810.1|7965229_7966963_-|hypothetical-protein
MYRLFWQMYYNTVFVDKLPGLSLIDILFDWDKLTGKSQLSGVYEEQMHKYFSHAQGRACFCAAYLITCYLLFLIFPFHWPTLVLFAGLALLLILVSFSPSALLSNGLSALAWLLLLTYGIIYALGLQEYWLLAFASAGTILQMVAPILWRKRKQVTRAALPRRRFVSLLLILILLPASFIPCLRYVILPQPAVYLASALWLMRTNAYRSSQLDWPQVIHNAEGMIQQARSSEDTYSTINYVLTSLGDHHSALIGAQQALDLSTGIGHGPGFLVEKVLATSWLQHKAVAVAFVFPGSSADRAGIKPGDIVTLLRRTPTEIKLLWQPGHSWQKKAISLDLRIPYAGELGTNGYRLADNIGYVNLYGTTGNAPQHYASQLQNLIKRLDTQPTCGWIIDLRLNTGGNIYPMLQGLGPILGAGSNLLSYVGPNGKVNVSFGYRNGAILIKGSPASFVPPLVPAYQPKIAQPPVALLISGNTASSGEGVLMAFLGRPATRTFGETTAGLSSSNITYQLIDGALLNIMSDIGMDRSGKVYGSTIQPDEAVKIDWSHYGTSQDPVIQRAERWLSTQAMCKASTAR
>CP035758.1|QBD83677.1|7964505_7965126_+|response-regulator-transcription-factor
MREGLRIILEDTADIEVIGEAQDGLGAIKQAEELEPDVILMDIRMPLCDGIEATERIRQQANGPRPRVLLLTTFDTPELVIEGMRAGASGYLLKDCSAEEVGSAIRTVARGQVLLQASSAVDLLAGLANAQASRPTSPTQGETFGLTARELDVVRLIAKGRNNAEIAQELSVSDSTVKTHINHIFTKLGARDRAHLVVLAHQFGLS
>CP035758.1|QBD80809.1|7963130_7964450_+|sensor-histidine-kinase
MNMLLDICLFEEGPKDEGTEHRPGLWSNIRAVRGIPRIFFTGDLLFSDLAALFLAVYIVVTSLSMPLPLLVLTESIYLILAVLIIASRGLNRFPLVFLMYCAALLCSLLLNVLVPNNWGAYGLYTICGLVLYRFPRRWSLPLIAADILILLATNHHLQNPWQWSNLESLLLSFGIAVAIGWGGWSQRTQYLLVARLHEVQEQLRVEMERTRELAAEHERTRIARDIHDVLSHTLSVLSIQVQAARHLLKRDPERLTAKLDDMAVLIRESIAESRRVVGLLREPSSVQASAPDSVGAGLRNTLTLFSERTGIRCKFEEAGTPSALSQEQIETLHYALREILTNAHRHGAARNVLITLRWREAAVILQGRDDGRGEAASASGPLSDKISMGSGGHHGLQGMRERANALGGELAAGPGEAGGFEVILRLPFNSSEQLQINSR
>CP035758.1|QBD80808.1|7962044_7962782_-|DUF1453-family-protein
MNGAGIILIVVVIVGFAIVRMLSEQPVTRSDIVAPVVAALVLGYIYLQKADPSMLALTIGGAFVGGLLGFIIAQFVHVWVDGTTGQVRQKGSWPFIGAYLGIAALRLAAEVVLHTSGLSQVLPLNEALLAMSIGIYLGRDLNIGLRALALTNWDINSLLNSDGSRNEPLSIFQGMRNQRWDNSMPPSSGPRWNNNQPMPYRDQRDQYWDNNQSTPYGDTRDQYWDDEMPQAGYRDRRVRRRDRYE
>CP035758.1|QBD80807.1|7960967_7962014_-|hypothetical-protein
MHNQEGMFAEQGMPEGTRERASRAMYEQPSRERAEYNYGEYNESYAEPGSRQQGGAKLRAPQQRSGRISIPMIVVLLLLIVLGVSGCLGLRLFESPLRDYTEASASHNFTVSSHPVLEIKGAKGDVHIHRGNTDQVTITAKMSGLDRAINANAIPVSYSQQGDTIAVTVSQSRDHFFAASTNLDVLAPETTSVQLDKQSGDVKIEDINGPITSHLADGHTELDNVQGRVDLESVKGDIELKNFTGQLNATTVHGHISLRDSELSGKSHLQTTEGDIEVEGSLDAQSNSSLSTDDGNIKLKLPPDAILQVSEHTSSGEYKNELAETSDNGPHPLLQLKTRKGDIRIEKQ
>CP035758.1|QBD80806.1|7960569_7960947_+|hypothetical-protein
MEQQYNSDRLPTISLNQRELQAINAIIEGYLPHLRRKLPYPYKTIKLLDDVRRKLAPALKPGAFPAGEALALSLEELQAIGIALQGFVALIYKIIPHSPERNATLEDLNKLRAAIEAILHPGEGA
>CP035758.1|QBD80805.1|7959939_7960449_+|hypothetical-protein
MMANSLYQLDLKNLIPVLASQRRSGRLIAELSSLPAVPIHKKCYTFAHILVRDGKPFAYEIWVNGELFIRGRRVIQALLLAGKLAWTLLNPEKQAQASQHDPSTQFPHRLQEPGRAEFMSWPRRRRQVYWLVDGGNSLARIAQLLSLPISQVTAELQSLRHQRWISFEV
>CP035758.1|QBD80804.1|7959210_7959753_-|DNA-binding-protein
MKEDKDIPKLSGYVSVKEAAEMLNVSDKMIYFYIDHKRLNAVRASNLLLIPTEELENFKQKSVGRPRTRTPAWRISSKDNALFVTSISVQIEAGQQDVLLKKLSAIRRKAAHEFPGTVARYIINYETTPNAIEILLIWKMGTMPDEVSREQALEAFRQELAEVLDWQSAQYKHGNAILHS
>CP035758.1|QBD80803.1|7958426_7958840_-|peptide-methionine-(R)-S-oxide-reductase
MSDLRNQPESYWKEKLTPEQYQVCRQKGTEPAFSGALYYNHDQGVYACAACGQPLFSSDAKFESGSGWPSFDQPMNREHVELHDDNSFFMHRTEVVCKNCGAHLGHVFDDGPRETTGKRYCINSLALDFQPKAAEAK
>CP035758.1|QBD80812.1|7968564_7970214_+|sigma-70-family-RNA-polymerase-sigma-factor
MNVAITEETTDAELVKLALADNKDAFRLLIERYQVMAICLTVRFTRNVEIARELVQEAMLQAYLSLDKLHDATRFKSWFYSITLNICRNWLRTHKEILSLDTQEGSQLLEQSSCLIQDPQEQLVTQEIQQIVGEAVRMLSTPYRDVAYLFYYEEMSMQKIAHHLHISLPAVKSRLHRGRKQLRQHLNALYPEEVYSTTAKRQRRTLLRTIFTGVIHPRYARADLVFLLHTQRHRTSSLLLQSQEQTAAGKALPDSTRQDVSAETDDMTQQSSASNQVNIRSKYMGGTMQNDQGRSFRFSAIWAGIIILGLPLSLGLAQLITNNTIKLISLGLTLSTWFAFCVALAFLTRGLRKHKIFNMGYMLPLVLPLVILLFIVISTFHIARNLGLDDSGSLLIAFALLAAWSSISILLSRTARSRYLALHALNWLFWLGMAIALAPWQLYASLYMGMTGLLAPWQILLFLAFPLSISLVLLSFYKTIIQRQQSFFQRGNSSSVMPKSDNQQSYEQGYRQSYSEGGTIYTYASQHEEPVAGYPWQDDMLTMKIEERP
>CP035758.1|QBD80813.1|7970308_7971934_-|OPT-family-oligopeptide-transporter
MEDATSRQEKHHPRLLEPVSLILNLLVAVLGAIIGLQLIVTLGVTPNTAIIGAIIAILVSRIPLHIFAKFRSVHRQNLMQTTISGATFGAANALLLPIGIPYLFGRADLVWPTLIGVACAMVVDAVVLFLIFDSRIFPASNAWPAGVATGEAIIAGDKGGRRGLLLVAGTVLGIVGSMLGASMSAFGVAFIGNIWALAMFGIGLLIKGYDKALFHMNIDTLYIPHGIMIGAGVVALFQVIWLLLKRRGNEQEGQAEENTDEALGISRQLTRTSRDVGNAVKWGFVAFLGCAIVLAVGTGLFTHMPLPQFIGWIIFAAIIAMAHELIVGLSAMHAGWFPAFAVALISLIVGMLLGFPPIALVILVAYAASTGPAFADMGYDFKTGWILRAGESQQFELEGRRQQFLSTLAGFVVAVVVVALIQHSYFSKGLIPPVDKVYVATIKAGLSNGGIATSLLIWAIPGALIQLIGGPSRQIGILLATGLLINNPMAGWSVIAGLIIRLIVLKLYGKKAEGPMSILAAGCIAGDALYSFFSSVWKASR
>CP035758.1|QBD80814.1|7971974_7972643_-|AroM-family-protein
MQKIGTITIGQSPRVDIVPELKTWLRADCEIIEKGALDGLSHAEIARLAPHEPQQDVLVTRLADGSSVTITHEAVIPRVQQCIRELEKEVSTILLLCTGTFPAFTTQVPLLIPEHLLYNFVRGIINPAFKLGVLTPSPDQVPHQQQRWQKNVAHVSVAAATPYADIAHVIEAGVALGKQGVDAIVLDCMGYTLEMKQRIRERVDCPVILSRAVLARVAAELA
>CP035758.1|QBD80815.1|7972821_7974384_-|PucR-family-transcriptional-regulator
MDQASLTVEELLQLPVLQNAQLVSGANGLQNEIRYIDVMEIPDLAGWLRPHEFVLTTGYAFQNNPYALGKLLDEMHKAGGAAVGVKQRRFGYQVSAEARHKSDSYAIPIIDIPPELTTIDITHSVMEKILNRQFVVLNKARAVNSELMKLLLRRRSAEIVTMIGNLLHCCVAVLNAGGSVLNATPGFDLSQVAQTREIRAANTILGYLVITEQPTQDDLFAQMCLDQATTALALEFTIQDAAKNRKEHAREEFLVELLSAPTRAEEALLVRAQRLDFPYGLYQFMLVVQPIFSAPALEELREDLWEQIHMLIVEGMSRGENGRKHLTVPLGESFAVLCVSSDAEIREAATQTAEQLYTRLQQRLANVEFSIGIGSIVNQLSALHESYSQARHAVEAGRKVFPARHIVHYEDVYIEDMLLSIGRHPALKMMYDSLLLPLCQYDQRNGTELLKTLEALLRHGGNTREVAEELYIHRNSVSYRLERIQDILQVNIFAPEIHIRLDLLMRAWKLQLLPLPEGTR
>CP035758.1|QBD80816.1|7974589_7975549_-|DUF1177-domain-containing-protein
MSLKQTIEIFELLDDSTVSGEKVKAFLEARGARHVTVTTVEGEKGSTDFVRVVIPGQRGKVLGGKAPTLAIVGRLGGIGARPERIGLVSDGDGAIAAMACALKLADMQTKGDILPGDVIISTHICPHAPTRPHHPVAFMDSPVDILTVNRHEVSQEMDAILSIDTTKGNRLFNHRGIAISPTVKEGYILKFSDDLINLLEMSTGQPAHTFGITMQDITPYGNGLYHVNSILQPAVATAAPVVGVAITAETVVPGCATGASHEVDIALAVKFSLEVAKAFGDEQCAFYDPQEFARMQQLYGSMAHLQTLGKSLPAAGKVS
>CP035758.1|QBD80817.1|7975557_7976628_-|DUF917-family-protein
MASYILSTADVQAAVLGGALLGGGGGGSLTQGSTMGELALAVGTPQLLSLDELADDDLLAVVALVGAPSAREQYLKPVHYIRAIELLQARLGRKLAGITTNENGAGTTVNGWFQAAMLGLPVIDAPSNGRAHPTGVMGSMGLQQDASYVSIQAAAGGRADKYIETVVSGSLTTCASLIRKASVEAGGLVAVARNPVTVRYAREHAACGAIGQALELGRLMLKQQTKGGDAVARAAMEFLGGKIICQGTVENVTLNMQGGFDVGTVEIKDYALTFWNEYMTLEQGGERLGTFPDLIMTLQRATGIPIPTAELQQGEEIILVHVPRQRLLLGAGMRDPQLFKPIEQVIGKPVLSYIFA
>CP035758.1|QBD80818.1|7977042_7977747_+|N-acyl-homoserine-lactonase-family-protein
MSRNAVKRLYLMLVGSMPQYQIPIVCYLVQTGDGKNILIDSGLPEIIPEEDAEFENGQDVIKQLASIGLKPDDIDIVISTHYDIDHAGRHAAFTKAQYVVQRVHHLDAASNPRFAANRPQWDQPMERIQLVDGDTELLPGLELIETSGHVPGHQSVLVRLPKTGAILLPIDAVPFGEGFTRDAQDDGSNPDAEAIRASTIKLLDLVEREHIRLVIFGHDKGQWEGLKKLPEYYE
>CP035758.1|QBD80819.1|7978228_7979404_-|winged-helix-DNA-binding-domain-containing-protein
MMQSTTGELSLSWSQVAARRLVRHGLDTPAQGARPAEIVRALCGAHAQVVSAAFWSIGLRSASLTSTAVKDALWSEHSLIKTFGPRGTVHLLAAQDLPLWAGALSALPPSHNGQSQEVRLTPEQTDEVVKVIAAALSDTELTIDELSEAVIAATGSWAGELVMPAFNGMWPRWRMALAQAGICGALCFGPNRGSKVTYTNPRRFLPEFAPVEERRALTWLLKSYLSAYGPATPQHFAQWLNAPRSWAKELFNALSAELEPVKVNGSLAWVVAGDSTFPSSLPQSVRLLPYFDAYAVGGQPRELLFPGRATQRALTPSGQAGNYQVLLVDGIVAGVWHQRRSGRRLDITVEAFEQLSATQRRELDEQVERIGAFLNAQPCLTLGPVNVGAHA
>CP035758.1|QBD80820.1|7979400_7979934_-|VOC-family-protein
MTPQNNVQAIPEGYHSVTPWIISRDTARFLDFISKAFGAQELGRVYNEDGSIGHAEARIGDSIVMAFDAHEGWPDTPCFLRLFVPDGDAVYQQALAAGATAVSEMTSLAFGDRVGRLRDPFDNLWWIQTRLENLTFEEMAKRAAEPQYSEAMRSFQASLEQEMKRRSEAESHKDASR
>CP035758.1|QBD80821.1|7980084_7980567_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MNFVRLIGEEYMSMNYEEAARRAKTLNPQIIEEFRANGGKVKNFPGPEFLLLHTRGARTNQPHITPVRYIKDGHAYVIVASNAGSPRNPNWYYNILAHPNEVMIEVGTEQLNVHATVAPPAERERLFAELVRQAPDFAKAQEGTSRIMPMVLLERVAEKG

Crispr_ID: CP035758_29

• CRISPR_ID: CP035758_29
• CRISPR_location: 8358829-8360056
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 16 spacers

Consensus repeat of CP035758_29

Consensus_repeat	Method
GTAGAAGAGGGAAGNCCCGNNNNGAGGGTACTGNAAGN	CRT
GGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	CRISPRCasFinder

spacers of CP035758_29

>29.1|8358866|37|CP035758|CRT
GGTCAAACAGCATTTGTCGCGCATGAACATACGTTTG
>29.2|8358940|37|CP035758|CRT
AGTTCATGACATTATGAGCTTCTGCTTGGCTCATCCT
>29.3|8359014|38|CP035758|CRT
ACCAACTACCGGTACTCGGGGTGGAACTCCTTGTAGAG
>29.4|8359089|35|CP035758|CRT
AGATGAGCGCAAAGCTCGCTGCCTGTTGCGCAGGC
>29.5|8359161|36|CP035758|CRT
AGTTTCCGGAGATATGCCTAATACTTCTTGTAGTGC
>29.6|8359234|38|CP035758|CRT
AAGATTGCGGAATTTGAGCCAGCGGCCTGGTGCGTACT
>29.7|8359309|37|CP035758|CRT
ACATTTTTGCGGGTTGTGGCACACTCTGGGAGGTACG
>29.8|8359383|34|CP035758|CRT
TGGAAAGGAAAGACTCGTCCAGAACCTTGCGAAG
>29.9|8359454|39|CP035758|CRT
GCTGTGGTGAGCCAGACGAAGGAAGGTATGGCTCGTAAG
>29.10|8359530|38|CP035758|CRT
AGGCGAAGCCGCTGGTGCGTTGTTCTGGTGTAAATAAA
>29.11|8359605|37|CP035758|CRT
TGGCAGCTCGATCTCGTCGAGCGTGATTACGCCAGCT
>29.12|8359679|39|CP035758|CRT
ATACTTGATCTCTAAAATGTGGCAATAGAGGTTACATTG
>29.13|8359755|37|CP035758|CRT
GCCTTCTCCAGATGATATGGCACGGGCAGGGCCAGAG
>29.14|8359829|37|CP035758|CRT
TTCGCCTACTTCTTGAAGTAGGAGTGATTCTGGTAAA
>29.15|8359903|38|CP035758|CRT
TGAAGTGGCAGGGGCTCTAGCACAACTGGAGACAGAAT
>29.16|8359978|42|CP035758|CRT
CCAGAGCTTTCTCCTTCCACCTGATTCTCGATTGGTTCTCCA
>29.17|8359754|37|CP035758|CRISPRCasFinder
TGCCTTCTCCAGATGATATGGCACGGGCAGGGCCAGA

CRISPR arrays and Neighbor proteins around CP035758_29

CRISPR arrays

The CRISPR arrays of CP035758_29

>merge|CP035758|29|8358829-8360056|CRT,CRISPRCasFinder
GTTGGAGAGGGAAGGCCCGTTAGAGGGTACTGAAAGTGGTCAAACAGCATTTGTCGCGCATGAACATACGTTTGGTAGAAGAGGGAAGACCCGTGAAGAGGGTACTGCAAGAGTTCATGACATTATGAGCTTCTGCTTGGCTCATCCTGTAGGAGAGGGAAGACCCGTGAAGAGGGTACTGCAAGACCAACTACCGGTACTCGGGGTGGAACTCCTTGTAGAGGTAGGAGAGGGAAGACCCGTGAAGAGGGTACTGCAAGAGATGAGCGCAAAGCTCGCTGCCTGTTGCGCAGGCGTAGGAGAGGGAAGACCCATAGAGAGGGTACTGAAAGAGTTTCCGGAGATATGCCTAATACTTCTTGTAGTGCGTAGAAGAGGGAAGGCCTGGTTCGAGGGTACTGAAAGAAGATTGCGGAATTTGAGCCAGCGGCCTGGTGCGTACTGTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAAAGACATTTTTGCGGGTTGTGGCACACTCTGGGAGGTACGGTAGAAGAGGGAAGATCCGTGTAGAGGGTGCTGAAAGTGGAAAGGAAAGACTCGTCCAGAACCTTGCGAAGGTAGAAGAGGGAAGTCCCGGTTCGAGGGTACTGAAAGGCTGTGGTGAGCCAGACGAAGGAAGGTATGGCTCGTAAGGTAGAAGGGAGACGGCCATTTTAGAGGGTACTGAAAGAGGCGAAGCCGCTGGTGCGTTGTTCTGGTGTAAATAAAGTAGAAGAGGGAAGGCCCGGTGTGAGGGTACTGTAAGTGGCAGCTCGATCTCGTCGAGCGTGATTACGCCAGCTGTAGAAGAGGGAATGCCCGTGTAGAGGGTGCTGAAAGATACTTGATCTCTAAAATGTGGCAATAGAGGTTACATTGGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAGTGCCTTCTCCAGATGATATGGCACGGGCAGGGCCAGAGGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAGATTCGCCTACTTCTTGAAGTAGGAGTGATTCTGGTAAAGTAGAAGAGGGAAGGCCCGGAACGAGGGTACTGCAAGTGAAGTGGCAGGGGCTCTAGCACAACTGGAGACAGAATGTAGAAGAGGAAAGGCCCGTGTAGAGGGTACTGAAAGCCAGAGCTTTCTCCTTCCACCTGATTCTCGATTGGTTCTCCAGCAGAAGAGGGAAGGCCCGGAACGAGGGTACTGCAAG

>CP035758|29|10|8358829-8360056|CRT
GTTGGAGAGGGAAGGCCCGTTAGAGGGTACTGAAAGT	GGTCAAACAGCATTTGTCGCGCATGAACATACGTTTG
GTAGAAGAGGGAAGACCCGTGAAGAGGGTACTGCAAG	AGTTCATGACATTATGAGCTTCTGCTTGGCTCATCCT
GTAGGAGAGGGAAGACCCGTGAAGAGGGTACTGCAAG	ACCAACTACCGGTACTCGGGGTGGAACTCCTTGTAGAG
GTAGGAGAGGGAAGACCCGTGAAGAGGGTACTGCAAG	AGATGAGCGCAAAGCTCGCTGCCTGTTGCGCAGGC
GTAGGAGAGGGAAGACCCATAGAGAGGGTACTGAAAG	AGTTTCCGGAGATATGCCTAATACTTCTTGTAGTGC
GTAGAAGAGGGAAGGCCTGGTTCGAGGGTACTGAAAG	AAGATTGCGGAATTTGAGCCAGCGGCCTGGTGCGTACT
GTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAAAG	ACATTTTTGCGGGTTGTGGCACACTCTGGGAGGTACG
GTAGAAGAGGGAAGATCCGTGTAGAGGGTGCTGAAAG	TGGAAAGGAAAGACTCGTCCAGAACCTTGCGAAG
GTAGAAGAGGGAAGTCCCGGTTCGAGGGTACTGAAAG	GCTGTGGTGAGCCAGACGAAGGAAGGTATGGCTCGTAAG
GTAGAAGGGAGACGGCCATTTTAGAGGGTACTGAAAG	AGGCGAAGCCGCTGGTGCGTTGTTCTGGTGTAAATAAA
GTAGAAGAGGGAAGGCCCGGTGTGAGGGTACTGTAAG	TGGCAGCTCGATCTCGTCGAGCGTGATTACGCCAGCT
GTAGAAGAGGGAATGCCCGTGTAGAGGGTGCTGAAAG	ATACTTGATCTCTAAAATGTGGCAATAGAGGTTACATTG
GTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAGT	GCCTTCTCCAGATGATATGGCACGGGCAGGGCCAGAG
GTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAGA	TTCGCCTACTTCTTGAAGTAGGAGTGATTCTGGTAAA
GTAGAAGAGGGAAGGCCCGGAACGAGGGTACTGCAAG	TGAAGTGGCAGGGGCTCTAGCACAACTGGAGACAGAAT
GTAGAAGAGGAAAGGCCCGTGTAGAGGGTACTGAAAG	CCAGAGCTTTCTCCTTCCACCTGATTCTCGATTGGTTCTCCA
GCAGAAGAGGGAAGGCCCGGAACGAGGGTACTGCAAG

>CP035758|29|29|8359717-8359827|CRISPRCasFinder
GGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	TGCCTTCTCCAGATGATATGGCACGGGCAGGGCCAGA
GGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD81137.1|8346094_8349781_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81145.1|8354430_8355771_+|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
CP035758.1|QBD81146.1|8356058_8356451_+|hypothetical-protein	unknown	unknown	gnl|CDD|290790
CP035758.1|QBD81152.1|8366978_8369378_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl|CDD|223394
CP035758.1|QBD81139.1|8351137_8351575_-|VOC-family-protein	unknown	unknown	gnl|CDD|319941
CP035758.1|QBD81148.1|8363326_8363668_+|divalent-cation-tolerance-protein-CutA	unknown	unknown	gnl|CDD|376987
CP035758.1|QBD81149.1|8363841_8364546_+|UMP-kinase	unknown	unknown	gnl|CDD|239786
CP035758.1|QBD81138.1|8350464_8351079_-|aminoglycoside-adenylyltransferase	unknown	unknown	gnl|CDD|371202
CP035758.1|QBD81154.1|8372137_8372527_+|RidA-family-protein	unknown	unknown	gnl|CDD|223329
CP035758.1|QBD83693.1|8361149_8361890_+|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
CP035758.1|QBD81144.1|8353803_8354049_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81153.1|8369520_8371959_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl|CDD|223394
CP035758.1|QBD81140.1|8351938_8352730_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
CP035758.1|QBD83692.1|8360506_8361133_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
CP035758.1|QBD81147.1|8361929_8363045_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|316372
CP035758.1|QBD81143.1|8353488_8353740_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81150.1|8364667_8364976_+|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|224278
CP035758.1|QBD81141.1|8352732_8352993_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81151.1|8365744_8366053_+|zinc-binding-protein	unknown	unknown	gnl|CDD|379193
CP035758.1|QBD81142.1|8353063_8353492_-|response-regulator	unknown	unknown	gnl|CDD|333815

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD81145.1|8354430_8355771_+|XRE-family-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	0.000484566
CP035758.1|QBD81146.1|8356058_8356451_+|hypothetical-protein	gnl|CDD|290790	pfam14083, PGDYG, PGDYG protein. This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There is a conserved PGDYG motif.	0.000606464
CP035758.1|QBD81152.1|8366978_8369378_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl|CDD|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
CP035758.1|QBD81147.1|8361929_8363045_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|316372	pfam13847, Methyltransf_31, Methyltransferase domain. This family appears to have methyltransferase activity.	1.2339e-27
CP035758.1|QBD81148.1|8363326_8363668_+|divalent-cation-tolerance-protein-CutA	gnl|CDD|376987	pfam03091, CutA1, CutA1 divalent ion tolerance protein. Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).	2.98639e-30
CP035758.1|QBD81149.1|8363841_8364546_+|UMP-kinase	gnl|CDD|239786	cd04253, AAK_UMPK-PyrH-Pf, AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and via gene repression of carbamoyl phosphate synthetase (the first enzyme of the pyrimidine biosynthesis pathway). The UMP kinase of Pyrococcus furiosus (Pf) is known to function as a homohexamer, with GTP and UTP being allosteric effectors. Like other related enzymes (carbamate kinase, aspartokinase, and N-acetylglutamate kinase) the E. coli and most bacterial UMPKs have a conserved, N-terminal, lysine residue proposed to function in the catalysis of the phosphoryl group transfer, whereas most archaeal UMPKs (this CD) appear to lack this residue and the Pyrococcus furiosus structure has an additional Mg ion bound to the ATP molecule which is proposed to function as the catalysis instead. Members of this CD belong to the Amino Acid Kinase Superfamily (AAK).	2.64326e-60
CP035758.1|QBD83692.1|8360506_8361133_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.22683e-08
CP035758.1|QBD81154.1|8372137_8372527_+|RidA-family-protein	gnl|CDD|223329	COG0251, TdcF, Putative translation initiation inhibitor, yjgF family [Translation, ribosomal structure and biogenesis].	7.68378e-26
CP035758.1|QBD83693.1|8361149_8361890_+|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.17328e-13
CP035758.1|QBD81139.1|8351137_8351575_-|VOC-family-protein	gnl|CDD|319941	cd08353, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.8425e-74
CP035758.1|QBD81153.1|8369520_8371959_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl|CDD|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
CP035758.1|QBD81140.1|8351938_8352730_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.27667e-17
CP035758.1|QBD81150.1|8364667_8364976_+|antibiotic-biosynthesis-monooxygenase	gnl|CDD|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	4.04653e-19
CP035758.1|QBD81138.1|8350464_8351079_-|aminoglycoside-adenylyltransferase	gnl|CDD|371202	pfam10706, Aminoglyc_resit, Aminoglycoside-2''-adenylyltransferase. This family is conserved in Bacteria. It confers resistance to kanamycin, gentamicin, and tobramycin. The protein is also produced by plasmids in various bacterial species and confers resistance to essentially all clinically available aminoglycosides except streptomycin, and it eliminates the synergism between aminoglycosides and cell-wall active agents.	5.26528e-06
CP035758.1|QBD81151.1|8365744_8366053_+|zinc-binding-protein	gnl|CDD|379193	pfam13451, zf-trcl, Probable zinc-ribbon domain. This is a probable zinc-binding domain with two CxxC sequence motifs, found in various families of bacteria.	7.37913e-22
CP035758.1|QBD81142.1|8353063_8353492_-|response-regulator	gnl|CDD|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	1.4271e-20

Protein sequences

>CP035758.1|QBD81146.1|8356058_8356451_+|hypothetical-protein
MIEFKKYRKVAPTFARVLTVEDHEERHGVVQAPEGLLPFVPGDYLARDAKGEWVIRQATIQNRYQRMVPEDEEGFAQYLRTDVSFAAAMPEPFVIDGMRGKAGDYLIVNNESGGWPVDREIFEQTYQLVE
>CP035758.1|QBD81145.1|8354430_8355771_+|XRE-family-transcriptional-regulator
MRKAEIAAKIGISKNTMSRYIQGSHPVPNHIRQRFADVLGIPEALLFPPQVSPSPQQHLSLLQASMNPSGVIIQSEKGRFDITQKEEEGFMDPARRNILMKTVTAAAVFAGEQLAAPSAQELVERLSRIFGSAPPHLIDKQSVEYLQLRLERSWADQRARHLPPQALLRYLLKDLSELTNLLERSLPLSLRPRIVTITGATALLAGILSYEAWNDAQSQSFYQIAINAARETENPALEAVAWGWNSLLAQYSGHPEQALHYVQHGLISQAQVHQEIVGWLAAIEAELYATLGNARASLQALQRASEIKGEPGRNWGETFWAHFEPSQYRGYQGICYLRLAQNEPAKRRYVDRAQEVLQGTLEELDRSTRHRRPTLIVDVATTYALQDKKEQALQYALQAAQSLSETRFISRVPVLRLQSLQAFLCHVGASPTELGALDAAMKHLSL
>CP035758.1|QBD81144.1|8353803_8354049_-|hypothetical-protein
MEDRKQSPLTRQMVLDVLSQLNQAYRAYNTSLPSHIRVQLRTIFYQHYKWLLRWRIPFRFDQVQGCYLPPTLLHNSMSGAY
>CP035758.1|QBD81143.1|8353488_8353740_-|hypothetical-protein
MNEYSKSERKPSRQTILIVLDALSRAKIVQPIAHLVYEKEKLRETIRACETWLEHHKVAYHYDETCHMYVLDLPVERQEGTEP
>CP035758.1|QBD81142.1|8353063_8353492_-|response-regulator
MKPVCLLPALEPAVGSILVADDSPTVRKILEYTLRREGYAVRSFPDGVSMLRWLRDGGSVPRLILMDLVMPRLDGYQVAILLRKQATYAGTVLVLHTRCNGLLDRLKARLVGFEDYLTKPSTTQQILTLAALYCSPPRPESS
>CP035758.1|QBD81141.1|8352732_8352993_-|hypothetical-protein
MGQHREYLWIVGGVPAGEGKQEWGQLVRVYAVDEEQARARAEQRLEQLAPFAWQIERLHCCPHGFLIYRRIIPGSRLVDDETGEVC
>CP035758.1|QBD81140.1|8351938_8352730_+|alpha/beta-hydrolase
MSSKHTQRSKVSNGDVKLAVSLTGKGQQLIFFNGLGATQAIWKSVIRHLTGQYQVVTFDFRGHGKATGAKDYSFDSFLTDAEAVLAAWGKDKPLLVAWSMGADLAIRYAAAHPGSVGGILIIDGALPAQLIDDPEEVKRLLHNPWMRLGFFALGLIGMGYQLSPDEQLTLNMQLDASRKLILQVYEKLDCPVELILASKTAGEKGAYASRINMLWLAAAERLASTYPALPIHWLESIHQLPLKKPVELARAIDDFSRRVKREG
>CP035758.1|QBD81139.1|8351137_8351575_-|VOC-family-protein
MKIQRIDHVGVIVNDLAAAKAFFLDFGLEVLGEGEMEGKMLDRIVGLNDARTAFVMLGTSDGQANIELVKYYSPPDEQGIRPSLANTPGIRHIAFVVEDIEAIVAKLKKRGMEIFGEIQHFEGSYKLCYVRGPEGIILELAEQIK
>CP035758.1|QBD81138.1|8350464_8351079_-|aminoglycoside-adenylyltransferase
MTNQFGSWQPWQPEDVARFFSSLTVPWWIAGGWALDLFLGVQTREHEDIDILFLRRDQHEIRALLQGWDVQEAHPELLPGSWPFQEWKRDAPLAASVHDIWCRQHKNAPWALQLMVIDAEQDQWISRRTAQIRGPLSTLGSINEDGIPYLAPEIQLFYKAKGLRPKDEADFARTLPALDGKRREWLAQSLALVHPGHTWLTKLT
>CP035758.1|QBD81137.1|8346094_8349781_-|hypothetical-protein
MMAKARSGLLNEAEIRRAYALLTEPEQVIEVRCLDASLRNDSYYSGTYGGYFNNVGSLLAALASLREAHGIYLTLQSCRSELINRACNKLIRQKTGKGTSDKDITRYAWLPVDCDPQRVSGISASAHEHELALAQARLIREALREQGWPEPVLADSGNGAHLLYKIDLAVNDKQLVERVLKALAVNFSTAMVKVDQSVHNPARIWKLYGTLACKGDNTAERPYRMSRLLEVPNQVLTVPKTLLEAFAALADSISQLEEPEPSRAAERQRSQSRSFDLAQWIQEYNIATYGAQSWQDGTKWLLKQCPFCKECDRSAVLIQFAGGALSYKCQHERCKDKGWSEFRTYYEPEAYERKILAFPQTTAADQAPTHGSAEALSQAHTQRLKTTGAGAPGSHSSDDGTAMPRPAFRSQIPPKADCGLPRFIIGGQLREQIENALTLIEQANHQEPRLFLYLSTVSKVEQDENGRPFTMQIDRAALRNELNEVANFYILKKEGEQVNFVDSKPPRDLADQLLALPPGKWPLPPLKAIVEAPVLRANGTILDKPGYDAQTGLYYVPARGMERCQIPEQPTPEDVQAATSLIEKIFVDFPFEGQADRANAYALLLTPFVRYAVKKDIQLALLDANNAGTGKGLLANLVSIAATGETTSPMSAKNDDDEWRKAILTELLQSPRMVIIDNIRGMLESATLELMLTGGGLNERILGQSKSAKPKNEATWIATGNNLLIGGDLARRSYRIRLLSQTAKPEERTDFAIADLEQWMYDHRPEVVSALLTLARAWYVAGQPQPLHVPRLGSFTHWAQTVGGILEYAGIEGFQQNRDELKSRNNEEAQECEVFLAAWYEAYQGKWLSTAEITRHLQTEQNRRETQFENEPSANALFDALPASLRKALAERPKSFDVTLGRWLGKRIETVYGLAGYHLEKTVDSHTRASQWRVLLRVAEGCSTQGENDFGEHSLSPNQGAPAGFNLQQPSATTAAGQESLLQDAASGSATGSSMLISEKSTAHEAAEGSANLSSGAHSLESATENSTKPSSHTYSLENMEGSARPSSGDLSANDQLLSTDHKKIERPQTSLMSDAVENTATDAQPSPQAETNENIRYAQPLASTEDLTTIVLEEQAKATPGATTAGESPHSVQQENAANTAEDELSQYRELYYACVAQLKKKPPKFGDMLWYGPGSGWKNGFVSPQAYLQRLRELGHSEDRLKFWAGYYVMIRDLGRDDRRRKPEED
>CP035758.1|QBD83692.1|8360506_8361133_+|TetR/AcrR-family-transcriptional-regulator
MSEQRRQRLRMEISREAARLFWLQGIEATTGEQIADAVGLSVRTIWRYFRNKESCAEPVLMYSVEWFLSVLRSWPLECSFEEHYATELTKLAKRYREPDEEADDLAASKMIVLANTEPALRTTWLMACDQVEREFAVIIARRLQRATDDVEVRMHAAAATAVVRVFSEALNAAYLSGTDLATIGDPREHLARAVRQATGGAIGDPVVS
>CP035758.1|QBD83693.1|8361149_8361890_+|CPBP-family-intramembrane-metalloprotease
MPPVPPNHSQDSVNTGEALVRPAPNAVSRPGWPEIIVGLLVLVVVGYGVGSQLGRLGLNPIVYGLIFTALSGVAGIAGFVAAALLRIRSLSAFGVRRVPWRWLLIGIGAGLLAFVLKILVTMAYVRITNDTNNIQNVYAQGGSGGVLSLVLATVFLALLTPLGEELLFRGVITTALLRYGPVIGVVGSAVIFGLAHGINIVLPTALVVGLVNAELRRRSGSVWPGVIAHAVVNLPTVAVMVAAGIH
>CP035758.1|QBD81147.1|8361929_8363045_+|class-I-SAM-dependent-methyltransferase
MQRPARLADNKWKELKSLEISFHVFPPAEKSARPIELQSPQKPQEFPSPSSYQHAILAQKSKKCLIFRFQNSLFFWARNKRHLLSINQGEKKMHEQTPSTDNYVMGRAPAETRRLQAQSQLMNPATQRMIEQAGITAGMLVLDVGSGAGDVAMLLAERVGPRGSVLGIDIDPTVIETARARVEAAGYTNVSFLVGDIATLPLEAEFDAIVGRLVLVYQPSPTAIVRRLAHFLRPGGIIAFQEMDMVHSATAPAHPSNQLFERVVTWSVEAFRHAGLPIRMGLELYTVFTDAGLPAPHLSGEATFLVGTDWTAYDWTAETTRSLLPLILKFGVATAEEVQIETLAERLRAEALSQRLVVRGPDLIAAWTRIP
>CP035758.1|QBD81148.1|8363326_8363668_+|divalent-cation-tolerance-protein-CutA
MQEFIQIITALSSEELVRKITDTLIDKRLAASVWISGPMTSTYRWQGKIESTTDWVCTINTRRELYNAVEQAIKELYPSDDLGILALPVLTGNKSYLEWITQETQNATDRSSE
>CP035758.1|QBD81149.1|8363841_8364546_+|UMP-kinase
MALDYTETHVLKLGGSLFYPHDGLAISYIQQFAQFIRQQVAERKVRYFIFVGGGLIARQYRDAGRQILGHGVDDEDLDWLGIHATRLNAHLLRTVFRDIAHPNIIKDYSVIQKPEKPIVIASGWKPGWSTDYPAVILAKDYRVSSIIKLSNIDYVYDKDPRTSSDARPFEHLSWSEYRTMIDAEWKPGSNAPFDPIASEQAAELGITVKLVNGTKFANLEKALKGEPFIGTVIE
>CP035758.1|QBD81150.1|8364667_8364976_+|antibiotic-biosynthesis-monooxygenase
MYVIVVGLQIKPEHRQDFIEAAFQNSHDSRLNEPGTRRFELIKDESDPNRFYLSEAYEDKAAFEAHANGSYFQTFVAASSKCYAQKPVWLVKGTMMAPSDEA
>CP035758.1|QBD81151.1|8365744_8366053_+|zinc-binding-protein
MSFVDKTLKCRDCGNDFVFTAGEQEFYQQKGLMNQPSRCPECRAARRSAAGGVGTRSERAPREMHTVICAECGAETQVPFLPKNDRPVYCSPCYDKVRVARN
>CP035758.1|QBD81152.1|8366978_8369378_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MATNSDKVMNESTSVAQTMRKRDFPLSRMTLEDLLKETQQYLTPHDMERIKSAYDLANQAHKGAVRRSGEPYIQHPLEVALLLAGMRIDADGIMAALLHDVVEDTDYSLEDLSEQFGPGVANIVDGVTKFDALAGKQAPNEKDKAAETPAEAEPAPPPSLVDKRRLRSETVRKMLLAMAEDPRVVVLKLADRLHNMRTLSAMSPTQQQNTARETSEIYSPLARRLGMAIVQAELEDLAFSYLEPEKYLRLAREVEEEVRKRQPYIERVCQSLNEEMKRAGIRAEVCAWQKHLASINRKLMSSGEIGQIHDLISFRILVDTDNECYLALGHIHALWRPKDGRIKDFIANPKLNGYQSLHTTVFGLDNRLAEIQIRTHDMQRTADYGLASYWYLKERVGKEASPNSWRLSYREMVAWIEQLREWQRELPQSADEFVEAVKGDIFQEQIFVFTPKGEVKDLPRGSTPLDMAYRIHTDIGDHCAGARIITNMDDSGHLVTRLVPLDYELKGGEIVDIVTNRTVHPTRDWLSFARTAAARNKIRRYLKTYEREINLQLGRERLDLALKASGTAGINERIDELLQQIRAENSSASATLKKYATLDDIYVALGREDLYVENVLEYLLPLLRAQSEQAQEGEECSDGLNGHYHLGEGEVSGRSLVKLARCCCPIPGDSIVGVLHPSKGMYVHRSDCRVLRRYRDQTPGALVELNWLQIEPEYYMAPVNIVAHDRSGLLRDVAAVVADAGINMTAVTSTTNASLQKAVITATLEIPAVEGVLDQIERILRRLRQVKNVVSVERALSSK
>CP035758.1|QBD81153.1|8369520_8371959_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MAMLNSFVEQPFVPRETPDALSRLHALALRYMTSEEINLIIQAFHLAREAFQKSENSAAAPLLFRALDVASILADLMHVDAVGVAAGLVFEAVDADALSLNQVEEVLGASTARVVGSMLRLNILERRKQEVSAAGSRRSLEEDAGSSSSAESKKPRIREALRRQQAETVRKMFVAMAEDPRVVLLKLAYRLQAMRQMCQPTFKGDPQEMITMAQETREIYAPLAGRLGMSRIESELEDQAFQILEPDKFVWVRDLVELESKQWRSYVERVCTILRAEMAAIGVKAEVSGRVKHLYSFYKKLARTAGDVDDLEALKAAADINQIHDLIAFRILVTSTPDCYTALGHVHSLWKPKEGRIKDFIANPKPNGYSALHTTVFCLDDHLVEVQIRTHSMHEMAEYGVAMHWHYKDVGDNASASARELLTWLRQLSEWQHELRASDASDTEFVEAVKGDIFQEQIFVFTPKGEVKDLPVGSTPLDFAYRIHTKIGDSCAGARIITEAGSGETARLMTRMVPLDYELKSGEIVDIITSRSAHPTRDWLSFARTAAAKSKIRRYLKLHERDINIQIGRERLERELKMVTGRVLDAVSEDLENYLSDEYHLESFDDILAAVGADDVRPRAVVQRMIEYWQLREGKEGRENKDEEETVKLPAVSSVKPTTEARLKVAGVSGLLTRLANCCCPLPGDPIVGFVSRGKGVIVHRTDCRNIAGFRQREHERLIHVSWQGMSPMSYMAPIVITGRDRVGLTRDIVSTIADAGISLISIHSNVSGKGTVVVTTATLELDDLEQMYRLFTRLEKIKGVMHVARDLGGHR
>CP035758.1|QBD81154.1|8372137_8372527_+|RidA-family-protein
MTHISHNPAQVTAPIGGYSHGLEVKAGARLLFISGQIPETPDGYVPQQFAEQCRAIWNNIFAILQSAGMDKEHLVKVITFLTDASQVQANSEIRQQLLGDCHPALTVMIAQTLQSEWLLEIEAVAASYY

Crispr_ID: CP035758_28

• CRISPR_ID: CP035758_28
• CRISPR_location: 8356940-8358735
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 24 spacers

Consensus repeat of CP035758_28

Consensus_repeat	Method
TCTTTCAGTACCCTCACAGCGGGCATTCCCTCCTCAAC	PILER-CR
GTNGAAGAGGGAANGCCCGNNNNGAGGGTACTGAAA	CRT
GGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	CRISPRCasFinder
AGCGGGCATTCCCTCTTCTACC	PILER-CR
GGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	CRISPRCasFinder
GGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	CRISPRCasFinder
CGGGC----CTTCCCTCTTCTAC	PILER-CR
GGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	CRISPRCasFinder

spacers of CP035758_28

>28.1|8356978|35|CP035758|PILER-CR
GGAATACGCTGCTGCTGTGTCCCGGCGGGCAACGT
>28.2|8357051|35|CP035758|PILER-CR
TATTCACATGTTCCGAGGCGAATTGCACTAGAGCA
>28.3|8356976|38|CP035758|CRT
GAGGAATACGCTGCTGCTGTGTCCCGGCGGGCAACGTG
>28.4|8357049|38|CP035758|CRT
GATATTCACATGTTCCGAGGCGAATTGCACTAGAGCAG
>28.5|8357122|40|CP035758|CRT
GAAGCTATGCAAAAGATGCTCCTGAGCTTGCTACGGGAAG
>28.6|8357197|36|CP035758|CRT
GAGCTCTTGAGCAGCTTGTGTCGCATTTACATAATA
>28.7|8357268|38|CP035758|CRT
GGCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAA
>28.8|8357341|39|CP035758|CRT
AGTCGTCGAGGCGACTGGTCTCAACAATCTCATGCAGAC
>28.9|8357415|39|CP035758|CRT
AGTGTAATATTGCTCTATTTTTTTCTTGTACGCCTAGAG
>28.10|8357489|38|CP035758|CRT
AGTAACAAGCGAGATAAGTTCTTACGATGGGCAGAAGA
>28.11|8357562|38|CP035758|CRT
AGTCCTTTTGCCAAAGCGTCGCAGCCAGAGCGACCAGG
>28.12|8357635|38|CP035758|CRT
AGATAGGCAACACGGCTACAGCCTGGATATAATTCTTG
>28.13|8357708|39|CP035758|CRT
AGTTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTTG
>28.14|8357782|39|CP035758|CRT
AGACACATACCCGTGGACACAAATGCGGACGCGGATCTC
>28.15|8357856|37|CP035758|CRT
AGAAACTAAAGTATGTGCAAACTTGATATCTTCTTGC
>28.16|8357928|40|CP035758|CRT
AGCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGGT
>28.17|8358003|38|CP035758|CRT
GTATCCGGTTCACCACTGCTGACCGAAATTTGTGCAAG
>28.18|8358076|39|CP035758|CRT
AGACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
>28.19|8358150|37|CP035758|CRT
AGACCAGACCATTTGCAATCGCGGAGTAACACCGGAA
>28.20|8358222|38|CP035758|CRT
AGACTGGCAAGACGTGGACCCACTGGTTGACGACCAAC
>28.21|8358295|38|CP035758|CRT
AGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTAC
>28.22|8358368|40|CP035758|CRT
AGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATA
>28.23|8358443|40|CP035758|CRT
AGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGAC
>28.24|8358518|37|CP035758|CRT
AGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAAC
>28.25|8358590|36|CP035758|CRT
GAAGGTGGCGTCAACAGAATACGTGGCAACGAAGGC
>28.26|8358661|40|CP035758|CRT
GACGCCTGGAGCAAGCAGATAGGTTCGTAGTCGTCTTCAG
>28.27|8357269|37|CP035758|CRISPRCasFinder
GCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAA
>28.28|8357621|51|CP035758|PILER-CR
GTGAGGGTACTGAAAGATAGGCAACACGGCTACAGCCTGGATATAATTCTT
>28.29|8357694|52|CP035758|PILER-CR
TCGAGGGTACTGAAAGTTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTT
>28.30|8357768|52|CP035758|PILER-CR
TCGAGGGTACTGAAAGACACATACCCGTGGACACAAATGCGGACGCGGATCT
>28.31|8357636|37|CP035758|CRISPRCasFinder
GATAGGCAACACGGCTACAGCCTGGATATAATTCTTG
>28.32|8357710|37|CP035758|CRISPRCasFinder
TTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTTG
>28.33|8357929|38|CP035758|CRISPRCasFinder
GCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGG
>28.34|8358004|36|CP035758|CRISPRCasFinder
TATCCGGTTCACCACTGCTGACCGAAATTTGTGCAA
>28.35|8358077|38|CP035758|CRISPRCasFinder
GACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
>28.36|8358060|55|CP035758|PILER-CR
TAGTGAGGGTACTGAAAGACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
>28.37|8358134|66|CP035758|PILER-CR
GTTCGAGGGTACTGAAAGACCAGACCATTTGCAATCGCGGAGTAACACCGGAAGTTTAAAGGAAAC
>28.38|8358219|54|CP035758|PILER-CR
CTGTGAGGGTACTGAAAGACTGGCAAGACGTGGACCCACTGGTTGACGACCAAC
>28.39|8358292|54|CP035758|PILER-CR
CTGTGAGGGTACTGAAAGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTAC
>28.40|8358365|56|CP035758|PILER-CR
TAGTGAGGGTACTGAAAGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATA
>28.41|8358440|56|CP035758|PILER-CR
TAGTGAGGGTGCTGAAAGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGAC
>28.42|8358515|53|CP035758|PILER-CR
TAATGAGGGTACTGAAAGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAAC
>28.43|8358591|34|CP035758|CRISPRCasFinder
AAGGTGGCGTCAACAGAATACGTGGCAACGAAGG

CRISPR arrays and Neighbor proteins around CP035758_28

CRISPR arrays

The CRISPR arrays of CP035758_28

>merge|CP035758|28|8356940-8358735|PILER-CR,CRT,CRISPRCasFinder,PILER-CR,CRISPRCasFinder,CRISPRCasFinder,PILER-CR,CRISPRCasFinder
GTTGAGGAGGGAATGCCCGCTGTGAGGGTATTGAAAGAGGAATACGCTGCTGCTGTGTCCCGGCGGGCAACGTGTTGAGGAGGGAATGCCCGCTGTGAGGGTACTGAAAGATATTCACATGTTCCGAGGCGAATTGCACTAGAGCAGTTGAGGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAGCTATGCAAAAGATGCTCCTGAGCTTGCTACGGGAAGTTGAGGAGGGAATGCCCGTGAAGAGGGTACTGAAAGAGCTCTTGAGCAGCTTGTGTCGCATTTACATAATAGTAGAAGAGGGAAGACCCGTTGGAGGGTACTGAAAGGCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAAGTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAAAGTCGTCGAGGCGACTGGTCTCAACAATCTCATGCAGACATTGAAGAGAGAAGACCCGTGAAGAGGGTACTGAAAGTGTAATATTGCTCTATTTTTTTCTTGTACGCCTAGAGGTAGAAGAGAGAAGATCCGGTTCGAGGGTACTGAAAGTAACAAGCGAGATAAGTTCTTACGATGGGCAGAAGAGTAGAAGAGGGAAGGGCCGAAGAGAGGGAACTGAAAGTCCTTTTGCCAAAGCGTCGCAGCCAGAGCGACCAGGGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGATAGGCAACACGGCTACAGCCTGGATATAATTCTTGGTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGTTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTTGGTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGACACATACCCGTGGACACAAATGCGGACGCGGATCTCGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAACTAAAGTATGTGCAAACTTGATATCTTCTTGCGTAGAAGAGGGAAGACCCGTTGTGAGGGAACTGAAAGCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGGTGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAGTATCCGGTTCACCACTGCTGACCGAAATTTGTGCAAGGTAGAAGAGGGAAGACCCGTAGTGAGGGTACTGAAAGACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCGGTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGACCAGACCATTTGCAATCGCGGAGTAACACCGGAAGTTTAAAGGAAACGGCCCGCTGTGAGGGTACTGAAAGACTGGCAAGACGTGGACCCACTGGTTGACGACCAACGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTACGTAGAAGAGGGAATGCCCGTAGTGAGGGTACTGAAAGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATAGTAGAAGAGGGAATGCCCGTAGTGAGGGTGCTGAAAGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGACGTAGAAGAGGGAAGGCCCGTAATGAGGGTACTGAAAGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAACGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAGAAGGTGGCGTCAACAGAATACGTGGCAACGAAGGCGTTGAGGAGGGAAGGCCCGTTAGAGGGTACTGAAAGACGCCTGGAGCAAGCAGATAGGTTCGTAGTCGTCTTCAGTTGAAGAAGGAAGGCCGGTAGAGAGGATACTGAAA

>CP035758|28|12|8356940-8357123|PILER-CR
GTTGAGGAGGGAATGCCCGCTGTGAGGGTATTGAAAGA	GGAATACGCTGCTGCTGTGTCCCGGCGGGCAACGT
GTTGAGGAGGGAATGCCCGCTGTGAGGGTACTGAAAGA	TATTCACATGTTCCGAGGCGAATTGCACTAGAGCA
GTTGAGGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAGCTATGCAAAAGATGCTCCTGAGCTTGCTACGGGAAGTTGAGGAGGGAATGCCCGTGAAGAGGGTACTGAAAGAGCTCTTGAGCAGCTTGTGTCGCATTTACATAATAGTAGAAGAGGGAAGACCCGTTGGAGGGTACTGAAAGGCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAAGTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAAAGTCGTCGAGGCGACTGGTCTCAACAATCTCATGCAGACATTGAAGAGAGAAGACCCGTGAAGAGGGTACTGAAAGTGTAATATTGCTCTATTTTTTTCTTGTACGCCTAGAGGTAGAAGAGAGAAGATCCGGTTCGAGGGTACTGAAAGTAACAAGCGAGATAAGTTCTTACGATGGGCAGAAGAGTAGAAGAGGGAAGGGCCGAAGAGAGGGAACTGAAAGTCCTTTTGCCAAAGCGTCGCAGCCAGAGCGACCAGGGTAGAAGAGGGAATGCCCGCT	GTGAGGGTACTGAAAGATAGGCAACACGGCTACAGCCTGGATATAATTCTT
GGTAGAAGAGGGAATGCCCGGT	TCGAGGGTACTGAAAGTTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTT
GGTAGAAGAGGGAATGCCCGGT	TCGAGGGTACTGAAAGACACATACCCGTGGACACAAATGCGGACGCGGATCT
CGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAACTAAAGTATGTGCAAACTTGATATCTTCTTGCGTAGAAGAGGGAAGACCCGTTGTGAGGGAACTGAAAGCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGGTGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAGTATCCGGTTCACCACTGCTGACCGAAATTTGTGCAAGGTAGAAGAGGGAAGACCCG	TAGTGAGGGTACTGAAAGACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
GTAGAAGAGGGAATGCCCG	GTTCGAGGGTACTGAAAGACCAGACCATTTGCAATCGCGGAGTAACACCGGAAGTTTAAAGGAAAC
GGCCCGCTGTGAGGGTACT	GAAAGACTGGCAAGACGTGGACCCACTGGTTGACGACCAACGTAGAAGAGGGAA
TGCCCGCTGTGAGGGTACT	GAAAGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTACGTAGAAGAGGGAA
TGCCCGTAGTGAGGGTACT	GAAAGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATAGTAGAAGAGGGAA
TGCCCGTAGTGAGGGTGCT	GAAAGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGACGTAGAAGAGGGAA
GGCCCGTAATGAGGGTACT	GAAAGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAACGTAGAAGAGGGAA


>CP035758|28|9|8356941-8358735|CRT
TTGAGGAGGGAATGCCCGCTGTGAGGGTATTGAAA	GAGGAATACGCTGCTGCTGTGTCCCGGCGGGCAACGTG
TTGAGGAGGGAATGCCCGCTGTGAGGGTACTGAAA	GATATTCACATGTTCCGAGGCGAATTGCACTAGAGCAG
TTGAGGAGGGAATGCCCGCTGTGAGGGTACTGAAA	GAAGCTATGCAAAAGATGCTCCTGAGCTTGCTACGGGAAG
TTGAGGAGGGAATGCCCGTGAAGAGGGTACTGAAA	GAGCTCTTGAGCAGCTTGTGTCGCATTTACATAATA
GTAGAAGAGGGAAGACCCGTTGGAGGGTACTGAAA	GGCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAA
GTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAA	AGTCGTCGAGGCGACTGGTCTCAACAATCTCATGCAGAC
ATTGAAGAGAGAAGACCCGTGAAGAGGGTACTGAA	AGTGTAATATTGCTCTATTTTTTTCTTGTACGCCTAGAG
GTAGAAGAGAGAAGATCCGGTTCGAGGGTACTGAA	AGTAACAAGCGAGATAAGTTCTTACGATGGGCAGAAGA
GTAGAAGAGGGAAGGGCCGAAGAGAGGGAACTGAA	AGTCCTTTTGCCAAAGCGTCGCAGCCAGAGCGACCAGG
GTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAA	AGATAGGCAACACGGCTACAGCCTGGATATAATTCTTG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAA	AGTTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTTG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAA	AGACACATACCCGTGGACACAAATGCGGACGCGGATCTC
GTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAA	AGAAACTAAAGTATGTGCAAACTTGATATCTTCTTGC
GTAGAAGAGGGAAGACCCGTTGTGAGGGAACTGAA	AGCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGGT
GTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAA	GTATCCGGTTCACCACTGCTGACCGAAATTTGTGCAAG
GTAGAAGAGGGAAGACCCGTAGTGAGGGTACTGAA	AGACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAA	AGACCAGACCATTTGCAATCGCGGAGTAACACCGGAA
GTTTAAAGGAAACGGCCCGCTGTGAGGGTACTGAA	AGACTGGCAAGACGTGGACCCACTGGTTGACGACCAAC
GTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAA	AGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTAC
GTAGAAGAGGGAATGCCCGTAGTGAGGGTACTGAA	AGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATA
GTAGAAGAGGGAATGCCCGTAGTGAGGGTGCTGAA	AGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGAC
GTAGAAGAGGGAAGGCCCGTAATGAGGGTACTGAA	AGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAAC
GTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAA	GAAGGTGGCGTCAACAGAATACGTGGCAACGAAGGC
GTTGAGGAGGGAAGGCCCGTTAGAGGGTACTGAAA	GACGCCTGGAGCAAGCAGATAGGTTCGTAGTCGTCTTCAG
TTGAAGAAGGAAGGCCGGTAGAGAGGATACTGAAA

>CP035758|28|25|8357232-8357343|CRISPRCasFinder
AGTAGAAGAGGGAAGACCCGTTGGAGGGTACTGAAAG	GCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAA
GTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAAAGTCGTCGAGGCGACTGGTCTCAACAATCTCATGCAGACATTGAAGAGAGAAGACCCGTGAAGAGGGTACTGAAAGTGTAATATTGCTCTATTTTTTTCTTGTACGCCTAGAGGTAGAAGAGAGAAGATCCGGTTCGAGGGTACTGAAAGTAACAAGCGAGATAAGTTCTTACGATGGGCAGAAGAGTAGAAGAGGGAAGGGCCGAAGAGAGGGAACTGAAAGTCCTTTTGCCAAAGCGTCGCAGCCAGAGCGACCAGGGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAA	GATAGGCAACACGGCTACAGCCTGGATATAATTCTTG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAG	TTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTTG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGACACATACCCGTGGACACAAATGCGGACGCGGATCTCGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAACTAAAGTATGTGCAAACTTGATATCTTCTTGCGTAGAAGAGGGAAGACCCGTTGTGAGGGAACTGAAA	GCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGG
TGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	TATCCGGTTCACCACTGCTGACCGAAATTTGTGCAA
GGTAGAAGAGGGAAGACCCGTAGTGAGGGTACTGAAA	GACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGACCAGACCATTTGCAATCGCGGAGTAACACCGGAAGTTTAAAGGAAACGGCCCGCTGTGAGGGTACTGAAAGACTGGCAAGACGTGGACCCACTGGTTGACGACCAACGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTACGTAGAAGAGGGAATGCCCGTAGTGAGGGTACTGAAAGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATAGTAGAAGAGGGAATGCCCGTAGTGAGGGTGCTGAAAGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGACGTAGAAGAGGGAAGGCCCGTAATGAGGGTACTGAAAGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAACGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	AAGGTGGCGTCAACAGAATACGTGGCAACGAAGG


>CP035758|28|13|8357599-8357841|PILER-CR
	GGAATACGCTGCTGCTGTGTCCCGGCGGGCAACGT
GTTGAGGAGGGAATGCCCGCTGTGAGGGTACTGAAAGA	TATTCACATGTTCCGAGGCGAATTGCACTAGAGCA
GTTGAGGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAGCTATGCAAAAGATGCTCCTGAGCTTGCTACGGGAAGTTGAGGAGGGAATGCCCGTGAAGAGGGTACTGAAAGAGCTCTTGAGCAGCTTGTGTCGCATTTACATAATAGTAGAAGAGGGAAGACCCGTTGGAGGGTACTGAAAGGCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAAGTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAAAGTCGTCGAGGCGACTGGTCTCAACAATCTCATGCAGACATTGAAGAGAGAAGACCCGTGAAGAGGGTACTGAAAGTGTAATATTGCTCTATTTTTTTCTTGTACGCCTAGAGGTAGAAGAGAGAAGATCCGGTTCGAGGGTACTGAAAGTAACAAGCGAGATAAGTTCTTACGATGGGCAGAAGAGTAGAAGAGGGAAGGGCCGAAGAGAGGGAACTGAAAGTCCTTTTGCCAAAGCGTCGCAGCCAGAGCGACCAGGGTAGAAGAGGGAATGCCCGCT	GTGAGGGTACTGAAAGATAGGCAACACGGCTACAGCCTGGATATAATTCTT
GGTAGAAGAGGGAATGCCCGGT	TCGAGGGTACTGAAAGTTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTT
GGTAGAAGAGGGAATGCCCGGT	TCGAGGGTACTGAAAGACACATACCCGTGGACACAAATGCGGACGCGGATCT
CGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAACTAAAGTATGTGCAAACTTGATATCTTCTTGCGTAGAAGAGGGAAGACCCGTTGTGAGGGAACTGAAAGCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGGTGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAGTATCCGGTTCACCACTGCTGACCGAAATTTGTGCAAGGTAGAAGAGGGAAGACCCG	TAGTGAGGGTACTGAAAGACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
GTAGAAGAGGGAATGCCCG	GTTCGAGGGTACTGAAAGACCAGACCATTTGCAATCGCGGAGTAACACCGGAAGTTTAAAGGAAAC
GGCCCGCTGTGAGGGTACT	GAAAGACTGGCAAGACGTGGACCCACTGGTTGACGACCAACGTAGAAGAGGGAA
TGCCCGCTGTGAGGGTACT	GAAAGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTACGTAGAAGAGGGAA
TGCCCGTAGTGAGGGTACT	GAAAGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATAGTAGAAGAGGGAA
TGCCCGTAGTGAGGGTGCT	GAAAGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGACGTAGAAGAGGGAA
GGCCCGTAATGAGGGTACT	GAAAGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAACGTAGAAGAGGGAA


>CP035758|28|26|8357599-8357784|CRISPRCasFinder
	GCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAA
GTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAAAGTCGTCGAGGCGACTGGTCTCAACAATCTCATGCAGACATTGAAGAGAGAAGACCCGTGAAGAGGGTACTGAAAGTGTAATATTGCTCTATTTTTTTCTTGTACGCCTAGAGGTAGAAGAGAGAAGATCCGGTTCGAGGGTACTGAAAGTAACAAGCGAGATAAGTTCTTACGATGGGCAGAAGAGTAGAAGAGGGAAGGGCCGAAGAGAGGGAACTGAAAGTCCTTTTGCCAAAGCGTCGCAGCCAGAGCGACCAGGGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAA	GATAGGCAACACGGCTACAGCCTGGATATAATTCTTG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAG	TTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTTG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGACACATACCCGTGGACACAAATGCGGACGCGGATCTCGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAACTAAAGTATGTGCAAACTTGATATCTTCTTGCGTAGAAGAGGGAAGACCCGTTGTGAGGGAACTGAAA	GCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGG
TGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	TATCCGGTTCACCACTGCTGACCGAAATTTGTGCAA
GGTAGAAGAGGGAAGACCCGTAGTGAGGGTACTGAAA	GACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGACCAGACCATTTGCAATCGCGGAGTAACACCGGAAGTTTAAAGGAAACGGCCCGCTGTGAGGGTACTGAAAGACTGGCAAGACGTGGACCCACTGGTTGACGACCAACGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTACGTAGAAGAGGGAATGCCCGTAGTGAGGGTACTGAAAGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATAGTAGAAGAGGGAATGCCCGTAGTGAGGGTGCTGAAAGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGACGTAGAAGAGGGAAGGCCCGTAATGAGGGTACTGAAAGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAACGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	AAGGTGGCGTCAACAGAATACGTGGCAACGAAGG


>CP035758|28|27|8357892-8358152|CRISPRCasFinder
	GCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAA
GTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAAAGTCGTCGAGGCGACTGGTCTCAACAATCTCATGCAGACATTGAAGAGAGAAGACCCGTGAAGAGGGTACTGAAAGTGTAATATTGCTCTATTTTTTTCTTGTACGCCTAGAGGTAGAAGAGAGAAGATCCGGTTCGAGGGTACTGAAAGTAACAAGCGAGATAAGTTCTTACGATGGGCAGAAGAGTAGAAGAGGGAAGGGCCGAAGAGAGGGAACTGAAAGTCCTTTTGCCAAAGCGTCGCAGCCAGAGCGACCAGGGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAA	GATAGGCAACACGGCTACAGCCTGGATATAATTCTTG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAG	TTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTTG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGACACATACCCGTGGACACAAATGCGGACGCGGATCTCGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAACTAAAGTATGTGCAAACTTGATATCTTCTTGCGTAGAAGAGGGAAGACCCGTTGTGAGGGAACTGAAA	GCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGG
TGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	TATCCGGTTCACCACTGCTGACCGAAATTTGTGCAA
GGTAGAAGAGGGAAGACCCGTAGTGAGGGTACTGAAA	GACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGACCAGACCATTTGCAATCGCGGAGTAACACCGGAAGTTTAAAGGAAACGGCCCGCTGTGAGGGTACTGAAAGACTGGCAAGACGTGGACCCACTGGTTGACGACCAACGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTACGTAGAAGAGGGAATGCCCGTAGTGAGGGTACTGAAAGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATAGTAGAAGAGGGAATGCCCGTAGTGAGGGTGCTGAAAGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGACGTAGAAGAGGGAAGGCCCGTAATGAGGGTACTGAAAGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAACGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	AAGGTGGCGTCAACAGAATACGTGGCAACGAAGG


>CP035758|28|14|8358041-8358573|PILER-CR
	GGAATACGCTGCTGCTGTGTCCCGGCGGGCAACGT
GTTGAGGAGGGAATGCCCGCTGTGAGGGTACTGAAAGA	TATTCACATGTTCCGAGGCGAATTGCACTAGAGCA
GTTGAGGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAGCTATGCAAAAGATGCTCCTGAGCTTGCTACGGGAAGTTGAGGAGGGAATGCCCGTGAAGAGGGTACTGAAAGAGCTCTTGAGCAGCTTGTGTCGCATTTACATAATAGTAGAAGAGGGAAGACCCGTTGGAGGGTACTGAAAGGCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAAGTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAAAGTCGTCGAGGCGACTGGTCTCAACAATCTCATGCAGACATTGAAGAGAGAAGACCCGTGAAGAGGGTACTGAAAGTGTAATATTGCTCTATTTTTTTCTTGTACGCCTAGAGGTAGAAGAGAGAAGATCCGGTTCGAGGGTACTGAAAGTAACAAGCGAGATAAGTTCTTACGATGGGCAGAAGAGTAGAAGAGGGAAGGGCCGAAGAGAGGGAACTGAAAGTCCTTTTGCCAAAGCGTCGCAGCCAGAGCGACCAGGGTAGAAGAGGGAATGCCCGCT	GTGAGGGTACTGAAAGATAGGCAACACGGCTACAGCCTGGATATAATTCTT
GGTAGAAGAGGGAATGCCCGGT	TCGAGGGTACTGAAAGTTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTT
GGTAGAAGAGGGAATGCCCGGT	TCGAGGGTACTGAAAGACACATACCCGTGGACACAAATGCGGACGCGGATCT
CGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAACTAAAGTATGTGCAAACTTGATATCTTCTTGCGTAGAAGAGGGAAGACCCGTTGTGAGGGAACTGAAAGCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGGTGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAGTATCCGGTTCACCACTGCTGACCGAAATTTGTGCAAGGTAGAAGAGGGAAGACCCG	TAGTGAGGGTACTGAAAGACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
GTAGAAGAGGGAATGCCCG	GTTCGAGGGTACTGAAAGACCAGACCATTTGCAATCGCGGAGTAACACCGGAAGTTTAAAGGAAAC
GGCCCGCTGTGAGGGTACT	GAAAGACTGGCAAGACGTGGACCCACTGGTTGACGACCAACGTAGAAGAGGGAA
TGCCCGCTGTGAGGGTACT	GAAAGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTACGTAGAAGAGGGAA
TGCCCGTAGTGAGGGTACT	GAAAGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATAGTAGAAGAGGGAA
TGCCCGTAGTGAGGGTGCT	GAAAGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGACGTAGAAGAGGGAA
GGCCCGTAATGAGGGTACT	GAAAGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAACGTAGAAGAGGGAA
GGCCCG

>CP035758|28|28|8358554-8358662|CRISPRCasFinder
	GCCTGGGCCTGCGAGAAAGCCACAAGCCCCTTATCAA
GTAGAAGAGGGAAGGCCCGGTTCGAGGGTACTGAAAGTCGTCGAGGCGACTGGTCTCAACAATCTCATGCAGACATTGAAGAGAGAAGACCCGTGAAGAGGGTACTGAAAGTGTAATATTGCTCTATTTTTTTCTTGTACGCCTAGAGGTAGAAGAGAGAAGATCCGGTTCGAGGGTACTGAAAGTAACAAGCGAGATAAGTTCTTACGATGGGCAGAAGAGTAGAAGAGGGAAGGGCCGAAGAGAGGGAACTGAAAGTCCTTTTGCCAAAGCGTCGCAGCCAGAGCGACCAGGGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAA	GATAGGCAACACGGCTACAGCCTGGATATAATTCTTG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAG	TTATAGATTTCGAGATAGCGGGAGGAGGAGCGTCTTG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGACACATACCCGTGGACACAAATGCGGACGCGGATCTCGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGAAACTAAAGTATGTGCAAACTTGATATCTTCTTGCGTAGAAGAGGGAAGACCCGTTGTGAGGGAACTGAAA	GCTATGCCAGAGACAGAGGGCGAAGAAGAGTGCATCGG
TGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	TATCCGGTTCACCACTGCTGACCGAAATTTGTGCAA
GGTAGAAGAGGGAAGACCCGTAGTGAGGGTACTGAAA	GACCTGGGTATAGCGCAACGTCGTTTGCAATGAGGGCG
GTAGAAGAGGGAATGCCCGGTTCGAGGGTACTGAAAGACCAGACCATTTGCAATCGCGGAGTAACACCGGAAGTTTAAAGGAAACGGCCCGCTGTGAGGGTACTGAAAGACTGGCAAGACGTGGACCCACTGGTTGACGACCAACGTAGAAGAGGGAATGCCCGCTGTGAGGGTACTGAAAGTGGAAGATGAGATAGCCGAGTTGAAAGCACGGCTACGTAGAAGAGGGAATGCCCGTAGTGAGGGTACTGAAAGTGCTCACAAAGAAACTCCATCGCCTCTATCAATTCATAGTAGAAGAGGGAATGCCCGTAGTGAGGGTGCTGAAAGAGCTTTGGCGTGTCCATTCCACACGCCGGATACGAGACGTAGAAGAGGGAAGGCCCGTAATGAGGGTACTGAAAGAGCGTCCGTAGATGTTACTTTGATGGCTGGCCAACGTAGAAGAGGGAAGGCCCGTTGGAGGGTACTGAAAG	AAGGTGGCGTCAACAGAATACGTGGCAACGAAGG
CGTTGAGGAGGGAAGGCCCGTTAGAGGGTACTGAAAGA

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD81137.1|8346094_8349781_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81145.1|8354430_8355771_+|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
CP035758.1|QBD81146.1|8356058_8356451_+|hypothetical-protein	unknown	unknown	gnl|CDD|290790
CP035758.1|QBD81152.1|8366978_8369378_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl|CDD|223394
CP035758.1|QBD81139.1|8351137_8351575_-|VOC-family-protein	unknown	unknown	gnl|CDD|319941
CP035758.1|QBD81148.1|8363326_8363668_+|divalent-cation-tolerance-protein-CutA	unknown	unknown	gnl|CDD|376987
CP035758.1|QBD81149.1|8363841_8364546_+|UMP-kinase	unknown	unknown	gnl|CDD|239786
CP035758.1|QBD81138.1|8350464_8351079_-|aminoglycoside-adenylyltransferase	unknown	unknown	gnl|CDD|371202
CP035758.1|QBD81154.1|8372137_8372527_+|RidA-family-protein	unknown	unknown	gnl|CDD|223329
CP035758.1|QBD83693.1|8361149_8361890_+|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
CP035758.1|QBD81144.1|8353803_8354049_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81153.1|8369520_8371959_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	unknown	unknown	gnl|CDD|223394
CP035758.1|QBD81140.1|8351938_8352730_+|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
CP035758.1|QBD83692.1|8360506_8361133_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|366102
CP035758.1|QBD81147.1|8361929_8363045_+|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl|CDD|316372
CP035758.1|QBD81143.1|8353488_8353740_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81150.1|8364667_8364976_+|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|224278
CP035758.1|QBD81141.1|8352732_8352993_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81151.1|8365744_8366053_+|zinc-binding-protein	unknown	unknown	gnl|CDD|379193
CP035758.1|QBD81142.1|8353063_8353492_-|response-regulator	unknown	unknown	gnl|CDD|333815

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD81145.1|8354430_8355771_+|XRE-family-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	0.000484566
CP035758.1|QBD81146.1|8356058_8356451_+|hypothetical-protein	gnl|CDD|290790	pfam14083, PGDYG, PGDYG protein. This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There is a conserved PGDYG motif.	0.000606464
CP035758.1|QBD81152.1|8366978_8369378_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl|CDD|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
CP035758.1|QBD81147.1|8361929_8363045_+|class-I-SAM-dependent-methyltransferase	gnl|CDD|316372	pfam13847, Methyltransf_31, Methyltransferase domain. This family appears to have methyltransferase activity.	1.2339e-27
CP035758.1|QBD81148.1|8363326_8363668_+|divalent-cation-tolerance-protein-CutA	gnl|CDD|376987	pfam03091, CutA1, CutA1 divalent ion tolerance protein. Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).	2.98639e-30
CP035758.1|QBD81149.1|8363841_8364546_+|UMP-kinase	gnl|CDD|239786	cd04253, AAK_UMPK-PyrH-Pf, AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and via gene repression of carbamoyl phosphate synthetase (the first enzyme of the pyrimidine biosynthesis pathway). The UMP kinase of Pyrococcus furiosus (Pf) is known to function as a homohexamer, with GTP and UTP being allosteric effectors. Like other related enzymes (carbamate kinase, aspartokinase, and N-acetylglutamate kinase) the E. coli and most bacterial UMPKs have a conserved, N-terminal, lysine residue proposed to function in the catalysis of the phosphoryl group transfer, whereas most archaeal UMPKs (this CD) appear to lack this residue and the Pyrococcus furiosus structure has an additional Mg ion bound to the ATP molecule which is proposed to function as the catalysis instead. Members of this CD belong to the Amino Acid Kinase Superfamily (AAK).	2.64326e-60
CP035758.1|QBD83692.1|8360506_8361133_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|366102	pfam00440, TetR_N, Bacterial regulatory proteins, tetR family.	3.22683e-08
CP035758.1|QBD81154.1|8372137_8372527_+|RidA-family-protein	gnl|CDD|223329	COG0251, TdcF, Putative translation initiation inhibitor, yjgF family [Translation, ribosomal structure and biogenesis].	7.68378e-26
CP035758.1|QBD83693.1|8361149_8361890_+|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.17328e-13
CP035758.1|QBD81139.1|8351137_8351575_-|VOC-family-protein	gnl|CDD|319941	cd08353, VOC_like, uncharacterized subfamily of vicinal oxygen chelate (VOC) family. The vicinal oxygen chelate (VOC) superfamily is composed of structurally related proteins with paired beta.alpha.beta.beta.beta motifs that provide a metal coordination environment with two or three open or readily accessible coordination sites to promote direct electrophilic participation of the metal ion in catalysis. VOC domain is found in a variety of structurally related metalloproteins, including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases. A bound metal ion is required for protein activities for the members of this superfamily. A variety of metal ions have been found in the catalytic centers of these proteins including Fe(II), Mn(II), Zn(II), Ni(II) and Mg(II). The protein superfamily contains members with or without domain swapping. The proteins of this family share three conserved metal binding amino acids with the type I extradiol dioxygenases, which shows no domain swapping.	2.8425e-74
CP035758.1|QBD81153.1|8369520_8371959_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase	gnl|CDD|223394	COG0317, SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription].	0
CP035758.1|QBD81140.1|8351938_8352730_+|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	5.27667e-17
CP035758.1|QBD81150.1|8364667_8364976_+|antibiotic-biosynthesis-monooxygenase	gnl|CDD|224278	COG1359, COG1359, Uncharacterized conserved protein [Function unknown].	4.04653e-19
CP035758.1|QBD81138.1|8350464_8351079_-|aminoglycoside-adenylyltransferase	gnl|CDD|371202	pfam10706, Aminoglyc_resit, Aminoglycoside-2''-adenylyltransferase. This family is conserved in Bacteria. It confers resistance to kanamycin, gentamicin, and tobramycin. The protein is also produced by plasmids in various bacterial species and confers resistance to essentially all clinically available aminoglycosides except streptomycin, and it eliminates the synergism between aminoglycosides and cell-wall active agents.	5.26528e-06
CP035758.1|QBD81151.1|8365744_8366053_+|zinc-binding-protein	gnl|CDD|379193	pfam13451, zf-trcl, Probable zinc-ribbon domain. This is a probable zinc-binding domain with two CxxC sequence motifs, found in various families of bacteria.	7.37913e-22
CP035758.1|QBD81142.1|8353063_8353492_-|response-regulator	gnl|CDD|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	1.4271e-20

Protein sequences

>CP035758.1|QBD81146.1|8356058_8356451_+|hypothetical-protein
MIEFKKYRKVAPTFARVLTVEDHEERHGVVQAPEGLLPFVPGDYLARDAKGEWVIRQATIQNRYQRMVPEDEEGFAQYLRTDVSFAAAMPEPFVIDGMRGKAGDYLIVNNESGGWPVDREIFEQTYQLVE
>CP035758.1|QBD81145.1|8354430_8355771_+|XRE-family-transcriptional-regulator
MRKAEIAAKIGISKNTMSRYIQGSHPVPNHIRQRFADVLGIPEALLFPPQVSPSPQQHLSLLQASMNPSGVIIQSEKGRFDITQKEEEGFMDPARRNILMKTVTAAAVFAGEQLAAPSAQELVERLSRIFGSAPPHLIDKQSVEYLQLRLERSWADQRARHLPPQALLRYLLKDLSELTNLLERSLPLSLRPRIVTITGATALLAGILSYEAWNDAQSQSFYQIAINAARETENPALEAVAWGWNSLLAQYSGHPEQALHYVQHGLISQAQVHQEIVGWLAAIEAELYATLGNARASLQALQRASEIKGEPGRNWGETFWAHFEPSQYRGYQGICYLRLAQNEPAKRRYVDRAQEVLQGTLEELDRSTRHRRPTLIVDVATTYALQDKKEQALQYALQAAQSLSETRFISRVPVLRLQSLQAFLCHVGASPTELGALDAAMKHLSL
>CP035758.1|QBD81144.1|8353803_8354049_-|hypothetical-protein
MEDRKQSPLTRQMVLDVLSQLNQAYRAYNTSLPSHIRVQLRTIFYQHYKWLLRWRIPFRFDQVQGCYLPPTLLHNSMSGAY
>CP035758.1|QBD81143.1|8353488_8353740_-|hypothetical-protein
MNEYSKSERKPSRQTILIVLDALSRAKIVQPIAHLVYEKEKLRETIRACETWLEHHKVAYHYDETCHMYVLDLPVERQEGTEP
>CP035758.1|QBD81142.1|8353063_8353492_-|response-regulator
MKPVCLLPALEPAVGSILVADDSPTVRKILEYTLRREGYAVRSFPDGVSMLRWLRDGGSVPRLILMDLVMPRLDGYQVAILLRKQATYAGTVLVLHTRCNGLLDRLKARLVGFEDYLTKPSTTQQILTLAALYCSPPRPESS
>CP035758.1|QBD81141.1|8352732_8352993_-|hypothetical-protein
MGQHREYLWIVGGVPAGEGKQEWGQLVRVYAVDEEQARARAEQRLEQLAPFAWQIERLHCCPHGFLIYRRIIPGSRLVDDETGEVC
>CP035758.1|QBD81140.1|8351938_8352730_+|alpha/beta-hydrolase
MSSKHTQRSKVSNGDVKLAVSLTGKGQQLIFFNGLGATQAIWKSVIRHLTGQYQVVTFDFRGHGKATGAKDYSFDSFLTDAEAVLAAWGKDKPLLVAWSMGADLAIRYAAAHPGSVGGILIIDGALPAQLIDDPEEVKRLLHNPWMRLGFFALGLIGMGYQLSPDEQLTLNMQLDASRKLILQVYEKLDCPVELILASKTAGEKGAYASRINMLWLAAAERLASTYPALPIHWLESIHQLPLKKPVELARAIDDFSRRVKREG
>CP035758.1|QBD81139.1|8351137_8351575_-|VOC-family-protein
MKIQRIDHVGVIVNDLAAAKAFFLDFGLEVLGEGEMEGKMLDRIVGLNDARTAFVMLGTSDGQANIELVKYYSPPDEQGIRPSLANTPGIRHIAFVVEDIEAIVAKLKKRGMEIFGEIQHFEGSYKLCYVRGPEGIILELAEQIK
>CP035758.1|QBD81138.1|8350464_8351079_-|aminoglycoside-adenylyltransferase
MTNQFGSWQPWQPEDVARFFSSLTVPWWIAGGWALDLFLGVQTREHEDIDILFLRRDQHEIRALLQGWDVQEAHPELLPGSWPFQEWKRDAPLAASVHDIWCRQHKNAPWALQLMVIDAEQDQWISRRTAQIRGPLSTLGSINEDGIPYLAPEIQLFYKAKGLRPKDEADFARTLPALDGKRREWLAQSLALVHPGHTWLTKLT
>CP035758.1|QBD81137.1|8346094_8349781_-|hypothetical-protein
MMAKARSGLLNEAEIRRAYALLTEPEQVIEVRCLDASLRNDSYYSGTYGGYFNNVGSLLAALASLREAHGIYLTLQSCRSELINRACNKLIRQKTGKGTSDKDITRYAWLPVDCDPQRVSGISASAHEHELALAQARLIREALREQGWPEPVLADSGNGAHLLYKIDLAVNDKQLVERVLKALAVNFSTAMVKVDQSVHNPARIWKLYGTLACKGDNTAERPYRMSRLLEVPNQVLTVPKTLLEAFAALADSISQLEEPEPSRAAERQRSQSRSFDLAQWIQEYNIATYGAQSWQDGTKWLLKQCPFCKECDRSAVLIQFAGGALSYKCQHERCKDKGWSEFRTYYEPEAYERKILAFPQTTAADQAPTHGSAEALSQAHTQRLKTTGAGAPGSHSSDDGTAMPRPAFRSQIPPKADCGLPRFIIGGQLREQIENALTLIEQANHQEPRLFLYLSTVSKVEQDENGRPFTMQIDRAALRNELNEVANFYILKKEGEQVNFVDSKPPRDLADQLLALPPGKWPLPPLKAIVEAPVLRANGTILDKPGYDAQTGLYYVPARGMERCQIPEQPTPEDVQAATSLIEKIFVDFPFEGQADRANAYALLLTPFVRYAVKKDIQLALLDANNAGTGKGLLANLVSIAATGETTSPMSAKNDDDEWRKAILTELLQSPRMVIIDNIRGMLESATLELMLTGGGLNERILGQSKSAKPKNEATWIATGNNLLIGGDLARRSYRIRLLSQTAKPEERTDFAIADLEQWMYDHRPEVVSALLTLARAWYVAGQPQPLHVPRLGSFTHWAQTVGGILEYAGIEGFQQNRDELKSRNNEEAQECEVFLAAWYEAYQGKWLSTAEITRHLQTEQNRRETQFENEPSANALFDALPASLRKALAERPKSFDVTLGRWLGKRIETVYGLAGYHLEKTVDSHTRASQWRVLLRVAEGCSTQGENDFGEHSLSPNQGAPAGFNLQQPSATTAAGQESLLQDAASGSATGSSMLISEKSTAHEAAEGSANLSSGAHSLESATENSTKPSSHTYSLENMEGSARPSSGDLSANDQLLSTDHKKIERPQTSLMSDAVENTATDAQPSPQAETNENIRYAQPLASTEDLTTIVLEEQAKATPGATTAGESPHSVQQENAANTAEDELSQYRELYYACVAQLKKKPPKFGDMLWYGPGSGWKNGFVSPQAYLQRLRELGHSEDRLKFWAGYYVMIRDLGRDDRRRKPEED
>CP035758.1|QBD83692.1|8360506_8361133_+|TetR/AcrR-family-transcriptional-regulator
MSEQRRQRLRMEISREAARLFWLQGIEATTGEQIADAVGLSVRTIWRYFRNKESCAEPVLMYSVEWFLSVLRSWPLECSFEEHYATELTKLAKRYREPDEEADDLAASKMIVLANTEPALRTTWLMACDQVEREFAVIIARRLQRATDDVEVRMHAAAATAVVRVFSEALNAAYLSGTDLATIGDPREHLARAVRQATGGAIGDPVVS
>CP035758.1|QBD83693.1|8361149_8361890_+|CPBP-family-intramembrane-metalloprotease
MPPVPPNHSQDSVNTGEALVRPAPNAVSRPGWPEIIVGLLVLVVVGYGVGSQLGRLGLNPIVYGLIFTALSGVAGIAGFVAAALLRIRSLSAFGVRRVPWRWLLIGIGAGLLAFVLKILVTMAYVRITNDTNNIQNVYAQGGSGGVLSLVLATVFLALLTPLGEELLFRGVITTALLRYGPVIGVVGSAVIFGLAHGINIVLPTALVVGLVNAELRRRSGSVWPGVIAHAVVNLPTVAVMVAAGIH
>CP035758.1|QBD81147.1|8361929_8363045_+|class-I-SAM-dependent-methyltransferase
MQRPARLADNKWKELKSLEISFHVFPPAEKSARPIELQSPQKPQEFPSPSSYQHAILAQKSKKCLIFRFQNSLFFWARNKRHLLSINQGEKKMHEQTPSTDNYVMGRAPAETRRLQAQSQLMNPATQRMIEQAGITAGMLVLDVGSGAGDVAMLLAERVGPRGSVLGIDIDPTVIETARARVEAAGYTNVSFLVGDIATLPLEAEFDAIVGRLVLVYQPSPTAIVRRLAHFLRPGGIIAFQEMDMVHSATAPAHPSNQLFERVVTWSVEAFRHAGLPIRMGLELYTVFTDAGLPAPHLSGEATFLVGTDWTAYDWTAETTRSLLPLILKFGVATAEEVQIETLAERLRAEALSQRLVVRGPDLIAAWTRIP
>CP035758.1|QBD81148.1|8363326_8363668_+|divalent-cation-tolerance-protein-CutA
MQEFIQIITALSSEELVRKITDTLIDKRLAASVWISGPMTSTYRWQGKIESTTDWVCTINTRRELYNAVEQAIKELYPSDDLGILALPVLTGNKSYLEWITQETQNATDRSSE
>CP035758.1|QBD81149.1|8363841_8364546_+|UMP-kinase
MALDYTETHVLKLGGSLFYPHDGLAISYIQQFAQFIRQQVAERKVRYFIFVGGGLIARQYRDAGRQILGHGVDDEDLDWLGIHATRLNAHLLRTVFRDIAHPNIIKDYSVIQKPEKPIVIASGWKPGWSTDYPAVILAKDYRVSSIIKLSNIDYVYDKDPRTSSDARPFEHLSWSEYRTMIDAEWKPGSNAPFDPIASEQAAELGITVKLVNGTKFANLEKALKGEPFIGTVIE
>CP035758.1|QBD81150.1|8364667_8364976_+|antibiotic-biosynthesis-monooxygenase
MYVIVVGLQIKPEHRQDFIEAAFQNSHDSRLNEPGTRRFELIKDESDPNRFYLSEAYEDKAAFEAHANGSYFQTFVAASSKCYAQKPVWLVKGTMMAPSDEA
>CP035758.1|QBD81151.1|8365744_8366053_+|zinc-binding-protein
MSFVDKTLKCRDCGNDFVFTAGEQEFYQQKGLMNQPSRCPECRAARRSAAGGVGTRSERAPREMHTVICAECGAETQVPFLPKNDRPVYCSPCYDKVRVARN
>CP035758.1|QBD81152.1|8366978_8369378_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MATNSDKVMNESTSVAQTMRKRDFPLSRMTLEDLLKETQQYLTPHDMERIKSAYDLANQAHKGAVRRSGEPYIQHPLEVALLLAGMRIDADGIMAALLHDVVEDTDYSLEDLSEQFGPGVANIVDGVTKFDALAGKQAPNEKDKAAETPAEAEPAPPPSLVDKRRLRSETVRKMLLAMAEDPRVVVLKLADRLHNMRTLSAMSPTQQQNTARETSEIYSPLARRLGMAIVQAELEDLAFSYLEPEKYLRLAREVEEEVRKRQPYIERVCQSLNEEMKRAGIRAEVCAWQKHLASINRKLMSSGEIGQIHDLISFRILVDTDNECYLALGHIHALWRPKDGRIKDFIANPKLNGYQSLHTTVFGLDNRLAEIQIRTHDMQRTADYGLASYWYLKERVGKEASPNSWRLSYREMVAWIEQLREWQRELPQSADEFVEAVKGDIFQEQIFVFTPKGEVKDLPRGSTPLDMAYRIHTDIGDHCAGARIITNMDDSGHLVTRLVPLDYELKGGEIVDIVTNRTVHPTRDWLSFARTAAARNKIRRYLKTYEREINLQLGRERLDLALKASGTAGINERIDELLQQIRAENSSASATLKKYATLDDIYVALGREDLYVENVLEYLLPLLRAQSEQAQEGEECSDGLNGHYHLGEGEVSGRSLVKLARCCCPIPGDSIVGVLHPSKGMYVHRSDCRVLRRYRDQTPGALVELNWLQIEPEYYMAPVNIVAHDRSGLLRDVAAVVADAGINMTAVTSTTNASLQKAVITATLEIPAVEGVLDQIERILRRLRQVKNVVSVERALSSK
>CP035758.1|QBD81153.1|8369520_8371959_+|bifunctional-(p)ppGpp-synthetase/guanosine-3',5'-bis(diphosphate)-3'-pyrophosphohydrolase
MAMLNSFVEQPFVPRETPDALSRLHALALRYMTSEEINLIIQAFHLAREAFQKSENSAAAPLLFRALDVASILADLMHVDAVGVAAGLVFEAVDADALSLNQVEEVLGASTARVVGSMLRLNILERRKQEVSAAGSRRSLEEDAGSSSSAESKKPRIREALRRQQAETVRKMFVAMAEDPRVVLLKLAYRLQAMRQMCQPTFKGDPQEMITMAQETREIYAPLAGRLGMSRIESELEDQAFQILEPDKFVWVRDLVELESKQWRSYVERVCTILRAEMAAIGVKAEVSGRVKHLYSFYKKLARTAGDVDDLEALKAAADINQIHDLIAFRILVTSTPDCYTALGHVHSLWKPKEGRIKDFIANPKPNGYSALHTTVFCLDDHLVEVQIRTHSMHEMAEYGVAMHWHYKDVGDNASASARELLTWLRQLSEWQHELRASDASDTEFVEAVKGDIFQEQIFVFTPKGEVKDLPVGSTPLDFAYRIHTKIGDSCAGARIITEAGSGETARLMTRMVPLDYELKSGEIVDIITSRSAHPTRDWLSFARTAAAKSKIRRYLKLHERDINIQIGRERLERELKMVTGRVLDAVSEDLENYLSDEYHLESFDDILAAVGADDVRPRAVVQRMIEYWQLREGKEGRENKDEEETVKLPAVSSVKPTTEARLKVAGVSGLLTRLANCCCPLPGDPIVGFVSRGKGVIVHRTDCRNIAGFRQREHERLIHVSWQGMSPMSYMAPIVITGRDRVGLTRDIVSTIADAGISLISIHSNVSGKGTVVVTTATLELDDLEQMYRLFTRLEKIKGVMHVARDLGGHR
>CP035758.1|QBD81154.1|8372137_8372527_+|RidA-family-protein
MTHISHNPAQVTAPIGGYSHGLEVKAGARLLFISGQIPETPDGYVPQQFAEQCRAIWNNIFAILQSAGMDKEHLVKVITFLTDASQVQANSEIRQQLLGDCHPALTVMIAQTLQSEWLLEIEAVAASYY

Crispr_ID: CP035758_30

• CRISPR_ID: CP035758_30
• CRISPR_location: 8547329-8548399
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 14 spacers

Consensus repeat of CP035758_30

Consensus_repeat	Method
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	CRISPRCasFinder
CTTGCAGTATCCTCAGNNCGGATCANGCCTCTGTAAC	CRT
CGGATCACGCCTCTGTAAC	PILER-CR

spacers of CP035758_30

>30.1|8547366|38|CP035758|CRISPRCasFinder,CRT
TATTCTTCGAGAACAGCTTTTACTACATTGTAATGCAA
>30.2|8547441|37|CP035758|CRISPRCasFinder,CRT
AACGCCAGATACTTCACATGAGGTCCTAAGCAAGGTT
>30.3|8547515|37|CP035758|CRISPRCasFinder,CRT
CTGACTATTGAACAGATAGCTGCCTTGATAGGAAAGC
>30.4|8547589|37|CP035758|CRISPRCasFinder,CRT
GACGAAAGAGCAGAGCCACCCCTACCAGCGCCAGGAA
>30.5|8547663|36|CP035758|CRISPRCasFinder,CRT
AGCACGGTCTGATCCTGGTGGAGAACAAGAACACCC
>30.6|8547736|37|CP035758|CRISPRCasFinder,CRT
TGCTCTATATTCCGCGCAATGTTCCAGAACCTGTCTA
>30.7|8547810|37|CP035758|CRISPRCasFinder,CRT
GCCATCCTCTCTATTCTAGCGCCTTTCTCTTTTATGT
>30.8|8547884|38|CP035758|CRISPRCasFinder,CRT
CGAAAGTACAGTGCAGCTCACGGCTGCACAATGCGAGA
>30.9|8547959|35|CP035758|CRISPRCasFinder,CRT
TAGTACAACGGTGGAAGCTCTGTCCAGCTTGTACC
>30.10|8548031|35|CP035758|CRISPRCasFinder,CRT
CACAATACAAGTTGGTTGACCATACAAGAATCAAG
>30.11|8548103|36|CP035758|CRISPRCasFinder,CRT
CTTAACAACATTAAGCACGAGATGGCTAATATTTCC
>30.12|8548176|38|CP035758|CRISPRCasFinder,CRT
ATGCACTTTCATATACTACTGCCTTCCTACAGCGGACT
>30.13|8548251|37|CP035758|CRISPRCasFinder,CRT
GCCATCTCCTGCATGCTACCAGCTCCTTGAAATGGAA
>30.14|8548325|38|CP035758|CRISPRCasFinder,CRT
CTAGAGGTGCCTGAGGCGATCTTAATAGCAGGTGTCTT
>30.15|8547366|56|CP035758|PILER-CR
TATTCTTCGAGAACAGCTTTTACTACATTGTAATGCAACTTGCAGTATCCTCAGAC
>30.16|8547441|55|CP035758|PILER-CR
AACGCCAGATACTTCACATGAGGTCCTAAGCAAGGTTCTTGCAGTATCCTCAGGA
>30.17|8547515|55|CP035758|PILER-CR
CTGACTATTGAACAGATAGCTGCCTTGATAGGAAAGCCTTGCAGTATCCTCAGGA
>30.18|8547589|55|CP035758|PILER-CR
GACGAAAGAGCAGAGCCACCCCTACCAGCGCCAGGAACTTGCAGTATCCTCAGAC
>30.19|8547663|54|CP035758|PILER-CR
AGCACGGTCTGATCCTGGTGGAGAACAAGAACACCCCTTGCAGTATCCTCAGGA
>30.20|8547736|55|CP035758|PILER-CR
TGCTCTATATTCCGCGCAATGTTCCAGAACCTGTCTACTTGCAGTATCCTCAGAC
>30.21|8547810|55|CP035758|PILER-CR
GCCATCCTCTCTATTCTAGCGCCTTTCTCTTTTATGTCTTGCAGTATCCTCAGAC
>30.22|8547884|56|CP035758|PILER-CR
CGAAAGTACAGTGCAGCTCACGGCTGCACAATGCGAGACTTGCAGTATCCTCAGAC
>30.23|8547959|53|CP035758|PILER-CR
TAGTACAACGGTGGAAGCTCTGTCCAGCTTGTACCCTTGCAGTATCCTCAGAC
>30.24|8548031|53|CP035758|PILER-CR
CACAATACAAGTTGGTTGACCATACAAGAATCAAGCTTGCAGTATCCTCAGAA
>30.25|8548103|54|CP035758|PILER-CR
CTTAACAACATTAAGCACGAGATGGCTAATATTTCCCTTGCAGTATCCTCAGAA
>30.26|8548176|56|CP035758|PILER-CR
ATGCACTTTCATATACTACTGCCTTCCTACAGCGGACTCTTGCAGTATCCTCAGAA

CRISPR arrays and Neighbor proteins around CP035758_30

CRISPR arrays

The CRISPR arrays of CP035758_30

>merge|CP035758|30|8547329-8548399|CRISPRCasFinder,CRT,PILER-CR
CTTGTAGTATCCTCAGACCGGATCACGCCTCTGTAACTATTCTTCGAGAACAGCTTTTACTACATTGTAATGCAACTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAACAACGCCAGATACTTCACATGAGGTCCTAAGCAAGGTTCTTGCAGTATCCTCAGGACGGATCACGCCTCTGTAACCTGACTATTGAACAGATAGCTGCCTTGATAGGAAAGCCTTGCAGTATCCTCAGGACGGATCACGCCTCTGTAACGACGAAAGAGCAGAGCCACCCCTACCAGCGCCAGGAACTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAACAGCACGGTCTGATCCTGGTGGAGAACAAGAACACCCCTTGCAGTATCCTCAGGACGGATCACGCCTCTGTAACTGCTCTATATTCCGCGCAATGTTCCAGAACCTGTCTACTTGCAGTATCCTCAGACCGGATCAAGCCTCTGTAACGCCATCCTCTCTATTCTAGCGCCTTTCTCTTTTATGTCTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAACCGAAAGTACAGTGCAGCTCACGGCTGCACAATGCGAGACTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAACTAGTACAACGGTGGAAGCTCTGTCCAGCTTGTACCCTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAACCACAATACAAGTTGGTTGACCATACAAGAATCAAGCTTGCAGTATCCTCAGAACGGATCAAGCCTCTGTAACCTTAACAACATTAAGCACGAGATGGCTAATATTTCCCTTGCAGTATCCTCAGAACGGATCAAGCCTCTGTAACATGCACTTTCATATACTACTGCCTTCCTACAGCGGACTCTTGCAGTATCCTCAGAACGGATCAAGCCTCTGTAACGCCATCTCCTGCATGCTACCAGCTCCTTGAAATGGAACTTGCAGTATCCTCAAGACGGAAGAAGCCTCTGTAACCTAGAGGTGCCTGAGGCGATCTTAATAGCAGGTGTCTTCTTGCAGTATCCTCAAGACGGAAGAAGCCTCTGTTAC

>CP035758|30|30|8547329-8548399|CRISPRCasFinder
CTTGTAGTATCCTCAGACCGGATCACGCCTCTGTAAC	TATTCTTCGAGAACAGCTTTTACTACATTGTAATGCAA
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	AACGCCAGATACTTCACATGAGGTCCTAAGCAAGGTT
CTTGCAGTATCCTCAGGACGGATCACGCCTCTGTAAC	CTGACTATTGAACAGATAGCTGCCTTGATAGGAAAGC
CTTGCAGTATCCTCAGGACGGATCACGCCTCTGTAAC	GACGAAAGAGCAGAGCCACCCCTACCAGCGCCAGGAA
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	AGCACGGTCTGATCCTGGTGGAGAACAAGAACACCC
CTTGCAGTATCCTCAGGACGGATCACGCCTCTGTAAC	TGCTCTATATTCCGCGCAATGTTCCAGAACCTGTCTA
CTTGCAGTATCCTCAGACCGGATCAAGCCTCTGTAAC	GCCATCCTCTCTATTCTAGCGCCTTTCTCTTTTATGT
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	CGAAAGTACAGTGCAGCTCACGGCTGCACAATGCGAGA
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	TAGTACAACGGTGGAAGCTCTGTCCAGCTTGTACC
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	CACAATACAAGTTGGTTGACCATACAAGAATCAAG
CTTGCAGTATCCTCAGAACGGATCAAGCCTCTGTAAC	CTTAACAACATTAAGCACGAGATGGCTAATATTTCC
CTTGCAGTATCCTCAGAACGGATCAAGCCTCTGTAAC	ATGCACTTTCATATACTACTGCCTTCCTACAGCGGACT
CTTGCAGTATCCTCAGAACGGATCAAGCCTCTGTAAC	GCCATCTCCTGCATGCTACCAGCTCCTTGAAATGGAA
CTTGCAGTATCCTCAAGACGGAAGAAGCCTCTGTAAC	CTAGAGGTGCCTGAGGCGATCTTAATAGCAGGTGTCTT
CTTGCAGTATCCTCAAGACGGAAGAAGCCTCTGTTAC

>CP035758|30|11|8547329-8548399|CRT
CTTGTAGTATCCTCAGACCGGATCACGCCTCTGTAAC	TATTCTTCGAGAACAGCTTTTACTACATTGTAATGCAA
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	AACGCCAGATACTTCACATGAGGTCCTAAGCAAGGTT
CTTGCAGTATCCTCAGGACGGATCACGCCTCTGTAAC	CTGACTATTGAACAGATAGCTGCCTTGATAGGAAAGC
CTTGCAGTATCCTCAGGACGGATCACGCCTCTGTAAC	GACGAAAGAGCAGAGCCACCCCTACCAGCGCCAGGAA
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	AGCACGGTCTGATCCTGGTGGAGAACAAGAACACCC
CTTGCAGTATCCTCAGGACGGATCACGCCTCTGTAAC	TGCTCTATATTCCGCGCAATGTTCCAGAACCTGTCTA
CTTGCAGTATCCTCAGACCGGATCAAGCCTCTGTAAC	GCCATCCTCTCTATTCTAGCGCCTTTCTCTTTTATGT
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	CGAAAGTACAGTGCAGCTCACGGCTGCACAATGCGAGA
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	TAGTACAACGGTGGAAGCTCTGTCCAGCTTGTACC
CTTGCAGTATCCTCAGACCGGATCACGCCTCTGTAAC	CACAATACAAGTTGGTTGACCATACAAGAATCAAG
CTTGCAGTATCCTCAGAACGGATCAAGCCTCTGTAAC	CTTAACAACATTAAGCACGAGATGGCTAATATTTCC
CTTGCAGTATCCTCAGAACGGATCAAGCCTCTGTAAC	ATGCACTTTCATATACTACTGCCTTCCTACAGCGGACT
CTTGCAGTATCCTCAGAACGGATCAAGCCTCTGTAAC	GCCATCTCCTGCATGCTACCAGCTCCTTGAAATGGAA
CTTGCAGTATCCTCAAGACGGAAGAAGCCTCTGTAAC	CTAGAGGTGCCTGAGGCGATCTTAATAGCAGGTGTCTT
CTTGCAGTATCCTCAAGACGGAAGAAGCCTCTGTTAC

>CP035758|30|15|8547347-8548250|PILER-CR
CGGATCACGCCTCTGTAAC	TATTCTTCGAGAACAGCTTTTACTACATTGTAATGCAACTTGCAGTATCCTCAGAC
CGGATCACGCCTCTGTAAC	AACGCCAGATACTTCACATGAGGTCCTAAGCAAGGTTCTTGCAGTATCCTCAGGA
CGGATCACGCCTCTGTAAC	CTGACTATTGAACAGATAGCTGCCTTGATAGGAAAGCCTTGCAGTATCCTCAGGA
CGGATCACGCCTCTGTAAC	GACGAAAGAGCAGAGCCACCCCTACCAGCGCCAGGAACTTGCAGTATCCTCAGAC
CGGATCACGCCTCTGTAAC	AGCACGGTCTGATCCTGGTGGAGAACAAGAACACCCCTTGCAGTATCCTCAGGA
CGGATCACGCCTCTGTAAC	TGCTCTATATTCCGCGCAATGTTCCAGAACCTGTCTACTTGCAGTATCCTCAGAC
CGGATCAAGCCTCTGTAAC	GCCATCCTCTCTATTCTAGCGCCTTTCTCTTTTATGTCTTGCAGTATCCTCAGAC
CGGATCACGCCTCTGTAAC	CGAAAGTACAGTGCAGCTCACGGCTGCACAATGCGAGACTTGCAGTATCCTCAGAC
CGGATCACGCCTCTGTAAC	TAGTACAACGGTGGAAGCTCTGTCCAGCTTGTACCCTTGCAGTATCCTCAGAC
CGGATCACGCCTCTGTAAC	CACAATACAAGTTGGTTGACCATACAAGAATCAAGCTTGCAGTATCCTCAGAA
CGGATCAAGCCTCTGTAAC	CTTAACAACATTAAGCACGAGATGGCTAATATTTCCCTTGCAGTATCCTCAGAA
CGGATCAAGCCTCTGTAAC	ATGCACTTTCATATACTACTGCCTTCCTACAGCGGACTCTTGCAGTATCCTCAGAA
CGGATCAAGCCTCTGTAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP035758.1|QBD81292.1|8543106_8543622_-|DUF664-domain-containing-protein	unknown	unknown	gnl|CDD|225200
CP035758.1|QBD81303.1|8553610_8553895_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81297.1|8549397_8550114_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
CP035758.1|QBD81295.1|8546572_8547172_+|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224228
CP035758.1|QBD81301.1|8552871_8553123_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81291.1|8542046_8542907_+|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|375319
CP035758.1|QBD83698.1|8539839_8540262_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|281995
CP035758.1|QBD81294.1|8545367_8546390_-|LLM-class-flavin-dependent-oxidoreductase	unknown	unknown	gnl|CDD|274651
CP035758.1|QBD81299.1|8551815_8552043_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|379188
CP035758.1|QBD81300.1|8552560_8552806_+|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81289.1|8540967_8541477_+|Lrp/AsnC-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224439
CP035758.1|QBD81296.1|8548766_8549207_+|GNAT-family-N-acetyltransferase	unknown	unknown	gnl|CDD|366181
CP035758.1|QBD81288.1|8540367_8540796_-|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase	unknown	unknown	gnl|CDD|274679
CP035758.1|QBD81290.1|8541586_8541895_-|hypothetical-protein	unknown	unknown	unknown
CP035758.1|QBD81298.1|8550260_8551478_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
CP035758.1|QBD81302.1|8553119_8553557_+|response-regulator	unknown	unknown	gnl|CDD|333815
CP035758.1|QBD81304.1|8554093_8554513_-|ester-cyclase	unknown	unknown	gnl|CDD|377824
CP035758.1|QBD81305.1|8554647_8555721_-|dipeptide-epimerase	unknown	unknown	gnl|CDD|239435
CP035758.1|QBD81293.1|8543949_8545032_+|alpha-hydroxy-acid-oxidizing-protein	unknown	unknown	gnl|CDD|376451
CP035758.1|QBD81287.1|8538650_8539223_-|dihydrofolate-reductase	unknown	unknown	gnl|CDD|223340

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP035758.1|QBD81292.1|8543106_8543622_-|DUF664-domain-containing-protein	gnl|CDD|225200	COG2318, DinB, Uncharacterized protein conserved in bacteria [Function unknown].	0.000577027
CP035758.1|QBD81297.1|8549397_8550114_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	7.2273e-11
CP035758.1|QBD81295.1|8546572_8547172_+|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	8.67864e-11
CP035758.1|QBD81291.1|8542046_8542907_+|XRE-family-transcriptional-regulator	gnl|CDD|375319	pfam17765, MLTR_LBD, MmyB-like transcription regulator ligand binding domain. This domain is found in a family of actinobacterial transcription factors. The structure shows it has a PAS domain like fold and it is bound to Myristic acid.	2.49236e-54
CP035758.1|QBD83698.1|8539839_8540262_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase	gnl|CDD|281995	pfam04075, F420H2_quin_red, F420H(2)-dependent quinone reductase. This family of proteins is found in the genera Mycobacterium and Streptomyces. Member protein Rv3547 has been characterized as a deazaflavin-dependent nitroreductase. Rv1558 is an F420H(2)-dependent quinone reductase involved in oxidative stress protection.	1.24303e-32
CP035758.1|QBD81294.1|8545367_8546390_-|LLM-class-flavin-dependent-oxidoreductase	gnl|CDD|274651	TIGR03564, F420_MSMEG_4879, F420-dependent oxidoreductase, MSMEG_4879 family. Coenzyme F420 is produced by methanogenic archaea, a number of the Actinomycetes (including Mycobacterium tuberculosis), and rare members of other lineages. The resulting information-rich phylogenetic profile identifies candidate F420-dependent oxidoreductases within the family of luciferase-like enzymes (pfam00296), where the species range for the subfamily encompasses many F420-positive genomes without straying beyond. This family is uncharacterized, and named for member MSMEG_4879 from Mycobacterium smegmatis. [Unknown function, Enzymes of unknown specificity].	1.24065e-50
CP035758.1|QBD81299.1|8551815_8552043_-|XRE-family-transcriptional-regulator	gnl|CDD|379188	pfam13443, HTH_26, Cro/C1-type HTH DNA-binding domain. This is a helix-turn-helix domain that probably binds to DNA.	8.88167e-12
CP035758.1|QBD81289.1|8540967_8541477_+|Lrp/AsnC-family-transcriptional-regulator	gnl|CDD|224439	COG1522, Lrp, Transcriptional regulators [Transcription].	1.65109e-34
CP035758.1|QBD81296.1|8548766_8549207_+|GNAT-family-N-acetyltransferase	gnl|CDD|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.39723e-08
CP035758.1|QBD81288.1|8540367_8540796_-|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase	gnl|CDD|274679	TIGR03618, Rv1155_F420, PPOX class probable F420-dependent enzyme. A Genome Properties metabolic reconstruction for F420 biosynthesis shows that slightly over 10 percent of all prokaryotes with fully sequenced genomes, including about two thirds of the Actinomyces, make F420. The Partial Phylogenetic Profiling algorithm identifies this members of this protein family as high-scoring proteins to the F420 biosynthesis profile. A member of this family, Rv1155, was crytallized after expression in Escherichia coli, which does not synthesize F420; the crystal structure shown to resemble FMN-binding proteins, but with a recognizable empty cleft corresponding to, yet differing profounding from, the FMN site of pyridoxine 5'-phosphate oxidase. We propose that this protein family consists of F420-binding enzymes. [Unknown function, Enzymes of unknown specificity].	1.54691e-25
CP035758.1|QBD81298.1|8550260_8551478_-|XRE-family-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	1.17039e-06
CP035758.1|QBD81302.1|8553119_8553557_+|response-regulator	gnl|CDD|333815	pfam00072, Response_reg, Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	4.09779e-22
CP035758.1|QBD81304.1|8554093_8554513_-|ester-cyclase	gnl|CDD|377824	pfam07366, SnoaL, SnoaL-like polyketide cyclase. This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalyzing intramolecular aldol condensation.	1.02587e-35
CP035758.1|QBD81305.1|8554647_8555721_-|dipeptide-epimerase	gnl|CDD|239435	cd03319, L-Ala-DL-Glu_epimerase, L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of the murein peptide of peptidoglycan, of which L-Ala-D-Glu is a component. L-Ala-D/L-Glu epimerase is a member of the enolase-superfamily, which is characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion.	2.2748e-113
CP035758.1|QBD81293.1|8543949_8545032_+|alpha-hydroxy-acid-oxidizing-protein	gnl|CDD|376451	pfam01070, FMN_dh, FMN-dependent dehydrogenase.	1.68615e-154
CP035758.1|QBD81287.1|8538650_8539223_-|dihydrofolate-reductase	gnl|CDD|223340	COG0262, FolA, Dihydrofolate reductase [Coenzyme metabolism].	1.89606e-18

Protein sequences

>CP035758.1|QBD81295.1|8546572_8547172_+|TetR/AcrR-family-transcriptional-regulator
MAKRGPRPGFDRNEALRKALLTFWENGYEGTTIAQLREAMGDLCAPSVYAAFGSKDTLFREVVELYNLERAPYWQQAFAEPSTRGAIEALLRGAAISYTTPDQPRGCLIDLGTKGSSPGNTAIQDYLRACRQEHKERIKKRLQQGIAAGELDPGCDVEVLANFYYAVLRGLSSEANDGASREALLAIVDTTMKAWPGSR
>CP035758.1|QBD81294.1|8545367_8546390_-|LLM-class-flavin-dependent-oxidoreductase
MCERKDKKTMVQEQAATQISATTRPLRERVGISIKNGLKARYTVQEVVESIQKAEAAGIQQIWMPQIGPLDTPTIFTAAALQTQQIRFNVGVVPTYTRHPLILAQQALAFDQVAPGRLRLGIGSSNKVLIEDVYGVPMGKKPLSQTREYMSVLRAAIETGQVEYQGEFFQVHYHEETTASIPLIISALGEKAFETAGEISDGALPWLAPIPYLLEKALPALKKGAQSQQRPAPPIIAGVLVALSEDQQAVQRAVLQQIEHYLGLPYYIRLFANAGIPLGPDGTGSEELISALVAQGSAAAVEQRLRQILATEIGELNLTLIPVVDEQKEYAQLLRIIGNL
>CP035758.1|QBD81293.1|8543949_8545032_+|alpha-hydroxy-acid-oxidizing-protein
MVLPPLNLFEYEKQAQEHLDTAVWDHYQGGSDDEVTLRACRDAFAQVWLRPRALVDVSSCDLRTTVLGTPISVPVLVAPTGGQGLAHSEGELATVRGAGAAGTLMVVAMFSTRSLEEIAQQATGPRWLQLYVRSRAQTRHVVQRAQAAGYQALVLTVDSPRPARCERDWRNGFAGFPFGNYDEAEFIDPRATEGDKALIQDAVTWEMLDWLRSLTSLPIVLKGILTAEDARFALEHGVAGLIVSNHGGRRLDGSVPALMALPEVIEAVAGRCEVYLDGGIRRGTDVLKALALGARAVLVGRPVLWGLAVNGEQGVRHVLSILSQELETAMALAGCPGVKQIHSSLVRQRGTFGSREPASL
>CP035758.1|QBD81292.1|8543106_8543622_-|DUF664-domain-containing-protein
MAEQASPLVTFYKLGWENHHQALVKTIAQLSAEQLANNLVAAHYISIGELLAHMIAARITWFCGWMGEGKAAREQWHEVQSRTDPAELIAIFEKTWQVISSAMDRWTSTDLEQLILPPASHQAWLRAKGLEEEPPHTRQWIIWHVLEHEIHHGGELSLALGTHGLDDFYTW
>CP035758.1|QBD81291.1|8542046_8542907_+|XRE-family-transcriptional-regulator
MKAMSEKERREELAKFLRTRRERITPQQAGFPAGLRRRTPGLRREELAQLAGVGATWYTWLEQGRAISVSAQVLESLARALQLDADERAHLFILARQQVPADPFPLTQTIDADLQLILDTMGIYPAWVLNPRWDIVAWNQAACHAFGDIGALTSRERHLLWLLFADPYYRTMFVDWEASAQHTLAFFRGSTQRYIGEPWLTQLIDELSQVSPEFREWWPRHDIQGRQTEQKQLKHPLVGLLELQPRTFQVVDRPDLQMIIYTPVSGTKTAAKLEQLSQSSMLSNHA
>CP035758.1|QBD81290.1|8541586_8541895_-|hypothetical-protein
MVLTIILALMAGFWSTNGIPHYLTGILGQEAPTPFGKSSVVNLFEGYAAFLIGGVFWYLTWLQQGNPVLVFISAAIGALAVDLFHAHYWRAGIGAAFRREKA
>CP035758.1|QBD81289.1|8540967_8541477_+|Lrp/AsnC-family-transcriptional-regulator
MTLRSEKPLDSTDWKILRELQRDARLSFNELGRRVGLSSPSTAERVRRLEEAGILTDYGARVEPTRVGLPVQAFIQLRCAPGMCLFKTGSAEQFPEVLEMYKLSGNHCALLKVAVSSLPHLEALNERLGRYGEQITNIITSNVLTHRIIDQEQPEMDAHPPTNQSWNVQ
>CP035758.1|QBD81288.1|8540367_8540796_-|TIGR03618-family-F420-dependent-PPOX-class-oxidoreductase
MIPQDMYDLLRQRNPAIVGVDRPSGSPHLSPVWFLWGDDSFYFRIDKSTAKYRHLKRNPAISLLINDHTGFRFLTVYGQAQIMEDNPADIAAQIVHKYYAPALAPERMPPEEEPDVVTIKLRPEKVVAIVEEIAREAANSWS
>CP035758.1|QBD83698.1|8539839_8540262_-|nitroreductase-family-deazaflavin-dependent-oxidoreductase
MQSQKEYNQKVIAEFHANGGKVADFGSTPLILLTTIGAKSGQERITPLAYTIDNDRFILIASDKGSPVHPGWYHNILAQPLVTVETSSERFQARAVVTEEPERSRLFTQMAEQMPAFAEYQERTSRKIPVIALVRLGTTC
>CP035758.1|QBD81287.1|8538650_8539223_-|dihydrofolate-reductase
MRKVIVMMHISLDGFAVSNEGTGLEWTFRGISDEVSQAAYENMRDVDTIIWGRSTYQGMYSYWPTVPANPESKPDEIEHAHWLDRTTKLVFSTTLETAEWVNSKLIKGNIAEEINTLKRQEGQNMLILGSPRLAHSFMALNLIDEYRLFLHPVTLGEGLPLFKEQAYLKLSATKTFANGVVHLRYQPDAQ
>CP035758.1|QBD81296.1|8548766_8549207_+|GNAT-family-N-acetyltransferase
MDYQLKTSFEAEPEFAAYLNERINEFNYQHSPPHNQARAEGAITPVRIMVVDSAGQWQGGISADLYWNWLELKDFWLSETLRGQGLGSSVLAQIEQIGRERGASKVLLTTFEFQARTFYERHGYKVVGMIEDYPPGSSYYTMVKVL
>CP035758.1|QBD81297.1|8549397_8550114_-|alpha/beta-hydrolase
MMATYVFVAGGGWGGFIWREVASRLRGHGHEAFTPTLTGVGERVHLASPQIDLETHVQDILGVLEYEDLHKVILVGHSYGGTVITAVAERVPERLAQLVYLNGLIPQDGQSAWDVTDPGLRARMQQRVREQGDGWRLLPPPGAPARITAHPFKPLTQPLTIQNPAAARLPHTFVYCTQIRVKGKLTIDAIAARVRAEGWHFYEVEADHMAMVTAPKAVTDILLEISEAPWLKSSRETV
>CP035758.1|QBD81298.1|8550260_8551478_-|XRE-family-transcriptional-regulator
MAFHYGQIIKEYRERHKMTQAKLAELWPKKDGGVGVNTRYVQDVEYGSKKIDDQGTLRKLATLLEIPLWRFGLSEYDPFNPASLPGAGVKLYNETLDVTEGFIKQTLAMRRTASLPEVQRSAQSLQRLFDYFSTYTPPSTRLEPRFLSLYAQGQSLQGLMYFEHRQYAQALETFEAMYATSQQLGDPVLQVHALQKLAVELNRARRKQEAVQAMEEARDLSFKASKYVAAFANAYLAHIYAAAGEALRFERAITTAQSLAASLGSSYGDGTDFVVHKMSSILQLRSRGYLRIGEPRKTLALHDELRSQIQQDSNLWLDFRLQLYRAKAYLMLHDVEACLEAAREFFRDVVDWRSPHRLSRGDELLRELEAAGYGELKAVKELKEELREAARNMASHQQNKTDARD
>CP035758.1|QBD81299.1|8551815_8552043_-|XRE-family-transcriptional-regulator
MLRLRVKEVAQDKGLSQGRLSRKANVDPTTLRRIYHDPFTIITTETLARLAEALNVPAAELIEDVPSASQGENQQ
>CP035758.1|QBD81300.1|8552560_8552806_+|hypothetical-protein
MMEEKKQQPLTNQVLYVLGQLNQAYRAYNTSLPSHIRVQLTTTFYQYYKWLLHWRIPFRFDQVQRCYLPPASLHNSMSGAY
>CP035758.1|QBD81301.1|8552871_8553123_+|hypothetical-protein
MKNAEQGGLKPSRQTILIVLDALSRAKMVLPIAQLAYEKEKLTETIRACVAWLDHYQVAYHYDKTCHMYVLDLPAEKQEGAEP
>CP035758.1|QBD81302.1|8553119_8553557_+|response-regulator
MKPVCLLPALEPAVGSILVADDSPTVRKILEYTLRREGYLVRAFPDGVSMLRWLHGGGPVPRLIFLDLVMPRMDGYQVASHLRKQAAYAGTVLVLHTRCNGLLDRLKARLIGIEGYLAKPSTTQQILTLAGHYCSPPLAEEVLWP
>CP035758.1|QBD81303.1|8553610_8553895_+|hypothetical-protein
MGQHREYLWVVGAVPAGEDMRDWSQLVRVYAVDEAQARIRAEHRLEQLAPFAWKLERLRCCPHGFLLYRRRYPGSRLVDDETGEVIEEHQQENS
>CP035758.1|QBD81304.1|8554093_8554513_-|ester-cyclase
MSIDQIKEVVRRFNIEVIQEGNLNSFQELMASDFINHSAPPNQPNGPESMWNTFQNVLRPALSNLTVTILDQVAEGDKVTTRKTITGVHTGVLLGVAATGRPVTIEVIDIVRVRDGRYSEHWGINTLPTVLAQLKQGSA
>CP035758.1|QBD81305.1|8554647_8555721_-|dipeptide-epimerase
MSGTTIKSINVEPLNIPLLEPFTIATGSVNSARNVLITVTLQDGSRGYGECAPFPPSTGESQETALAAAQGCAELLKGRDAAHWRVLAKLMRSVFYSQTTACAGMEMALLDALTRSYGIPLYTFFGGASSFVETDMSIPIVTPERGYELAKETVERGITSIKIKVGSDLREDVERVEAIRSGAPNLPLTLDANQGYTANEALLCLEALDDHDIRPILMEQPVHKDDYEGLRYVTQHTTVPVAADESAANSAAVARLIGMGAANVVNVKLMKSGIVDALDIAALCRAHHIQLMVGAMIESRLASSMAAHLVAGLGGFSFVDLDTPMLLAEDPFTGGYEQRGGIYDLSSVKSGLGIELK

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP035758_10	10.13|1707204|29|CP035758|CRISPRCasFinder,CRT	1707204-1707232	29	KF301602	Caulobacter phage Cr30, complete genome	24611-24639	5	0.828
CP035758_19	19.2|4437414|29|CP035758|CRT	4437414-4437442	29	NZ_AP022578	Mycolicibacterium aubagnense strain JCM 15296 plasmid pJCM15296, complete sequence	46374-46402	5	0.828
CP035758_18	18.1|4005950|28|CP035758|CRISPRCasFinder	4005950-4005977	28	MK493325	Synechococcus phage S-RIM8 isolate RW_62_0316, complete genome	95081-95108	6	0.786
CP035758_18	18.1|4005950|28|CP035758|CRISPRCasFinder	4005950-4005977	28	KX349286	Synechococcus phage S-RIM8 isolate RW_03_0807_WH8101, complete genome	95170-95197	6	0.786
CP035758_18	18.1|4005950|28|CP035758|CRISPRCasFinder	4005950-4005977	28	KX349290	Synechococcus phage S-RIM8 isolate RW_25_1112, complete genome	95081-95108	6	0.786
CP035758_18	18.1|4005950|28|CP035758|CRISPRCasFinder	4005950-4005977	28	KX349287	Synechococcus phage S-RIM8 isolate RW_06_0613, complete genome	95081-95108	6	0.786
CP035758_19	19.3|4437471|29|CP035758|CRT	4437471-4437499	29	JQ432563	Uncultured bacterium plasmid pMBUI1, complete sequence	1170-1198	7	0.759
CP035758_5	5.16|1372327|34|CP035758|CRISPRCasFinder	1372327-1372360	34	NZ_CP011399	Listeria monocytogenes strain CFSAN008100 plasmid pCFSAN008100, complete sequence	63067-63100	8	0.765
CP035758_5	5.16|1372327|34|CP035758|CRISPRCasFinder	1372327-1372360	34	NC_009813	Listeria phage B054, complete genome	42217-42250	8	0.765
CP035758_10	10.13|1707204|29|CP035758|CRISPRCasFinder,CRT	1707204-1707232	29	NZ_CP043619	Rhodobacteraceae bacterium SH-1 plasmid p1, complete sequence	9217-9245	8	0.724
CP035758_19	19.1|4437357|29|CP035758|CRT	4437357-4437385	29	NC_016623	Azospirillum lipoferum 4B plasmid AZO_p3, complete sequence	60822-60850	8	0.724
CP035758_13	13.9|2213323|31|CP035758|CRT	2213323-2213353	31	NC_010478	Synechococcus sp. PCC 7002 plasmid pAQ4, complete sequence	19228-19258	10	0.677
CP035758_29	29.14|8359829|37|CP035758|CRT	8359829-8359865	37	NZ_CP046318	Campylobacter coli strain FDAARGOS_735 plasmid unnamed1, complete sequence	7171-7207	10	0.73
CP035758_29	29.14|8359829|37|CP035758|CRT	8359829-8359865	37	NZ_CP046318	Campylobacter coli strain FDAARGOS_735 plasmid unnamed1, complete sequence	15049-15085	10	0.73
CP035758_19	19.6|4437471|34|CP035758|CRISPRCasFinder	4437471-4437504	34	NC_042014	Arthrobacter phage Piccoletto, complete genome	35921-35954	11	0.676
CP035758_29	29.14|8359829|37|CP035758|CRT	8359829-8359865	37	NZ_CP046318	Campylobacter coli strain FDAARGOS_735 plasmid unnamed1, complete sequence	22926-22962	11	0.703

1. spacer 10.13|1707204|29|CP035758|CRISPRCasFinder,CRT matches to KF301602 (Caulobacter phage Cr30, complete genome) position: , mismatch: 5, identity: 0.828

tccttatccacagcatcttttggaagatt	CRISPR spacer
accttatcaacagtatcttttggaagttg	Protospacer
 ******* ****.************ * 

2. spacer 19.2|4437414|29|CP035758|CRT matches to NZ_AP022578 (Mycolicibacterium aubagnense strain JCM 15296 plasmid pJCM15296, complete sequence) position: , mismatch: 5, identity: 0.828

cgccctcggctccgggcaatctggacagt-	CRISPR spacer
agccgtcggctccgggcaatct-gacatcg	Protospacer
 *** ***************** **** . 

3. spacer 18.1|4005950|28|CP035758|CRISPRCasFinder matches to MK493325 (Synechococcus phage S-RIM8 isolate RW_62_0316, complete genome) position: , mismatch: 6, identity: 0.786

ttagttttgctcttgcttgccagttata	CRISPR spacer
ttgcggatgctcttacttgccagttata	Protospacer
**.    *******.*************

4. spacer 18.1|4005950|28|CP035758|CRISPRCasFinder matches to KX349286 (Synechococcus phage S-RIM8 isolate RW_03_0807_WH8101, complete genome) position: , mismatch: 6, identity: 0.786

ttagttttgctcttgcttgccagttata	CRISPR spacer
ttgcggatgctcttacttgccagttata	Protospacer
**.    *******.*************

5. spacer 18.1|4005950|28|CP035758|CRISPRCasFinder matches to KX349290 (Synechococcus phage S-RIM8 isolate RW_25_1112, complete genome) position: , mismatch: 6, identity: 0.786

ttagttttgctcttgcttgccagttata	CRISPR spacer
ttgcggatgctcttacttgccagttata	Protospacer
**.    *******.*************

6. spacer 18.1|4005950|28|CP035758|CRISPRCasFinder matches to KX349287 (Synechococcus phage S-RIM8 isolate RW_06_0613, complete genome) position: , mismatch: 6, identity: 0.786

ttagttttgctcttgcttgccagttata	CRISPR spacer
ttgcggatgctcttacttgccagttata	Protospacer
**.    *******.*************

7. spacer 19.3|4437471|29|CP035758|CRT matches to JQ432563 (Uncultured bacterium plasmid pMBUI1, complete sequence) position: , mismatch: 7, identity: 0.759

tacgccgggcgctagccagcctagcagta	CRISPR spacer
gccaccggccgctagccaggctagcagcc	Protospacer
  *.**** ********** *******. 

8. spacer 5.16|1372327|34|CP035758|CRISPRCasFinder matches to NZ_CP011399 (Listeria monocytogenes strain CFSAN008100 plasmid pCFSAN008100, complete sequence) position: , mismatch: 8, identity: 0.765

tttgcaaagaagctgacaaaattattcgttttcg	CRISPR spacer
tgtctaaagaagatgacaaaatgattcgtcatct	Protospacer
* * .******* ********* ******. ** 

9. spacer 5.16|1372327|34|CP035758|CRISPRCasFinder matches to NC_009813 (Listeria phage B054, complete genome) position: , mismatch: 8, identity: 0.765

tttgcaaagaagctgacaaaattattcgttttcg	CRISPR spacer
tgtctaaagaagatgacaaaataattcgtcatct	Protospacer
* * .******* ********* ******. ** 

10. spacer 10.13|1707204|29|CP035758|CRISPRCasFinder,CRT matches to NZ_CP043619 (Rhodobacteraceae bacterium SH-1 plasmid p1, complete sequence) position: , mismatch: 8, identity: 0.724

tccttatccacagcatcttttggaagatt	CRISPR spacer
agtggatccactgcatctcttggaagatg	Protospacer
  .  ****** ******.********* 

11. spacer 19.1|4437357|29|CP035758|CRT matches to NC_016623 (Azospirillum lipoferum 4B plasmid AZO_p3, complete sequence) position: , mismatch: 8, identity: 0.724

tgccttcggccctaaccagcctagcagca	CRISPR spacer
tgccttcggccctgaccagcccgtcgaag	Protospacer
*************.*******.. *.. .

12. spacer 13.9|2213323|31|CP035758|CRT matches to NC_010478 (Synechococcus sp. PCC 7002 plasmid pAQ4, complete sequence) position: , mismatch: 10, identity: 0.677

gtcctacttccaaaggtgcattaactcccgt	CRISPR spacer
ttcctccttcaaaaggtgcattaaaagtaaa	Protospacer
 **** **** *************   . . 

13. spacer 29.14|8359829|37|CP035758|CRT matches to NZ_CP046318 (Campylobacter coli strain FDAARGOS_735 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.73

ttcgcctacttcttgaagtaggagtgattctggtaaa	CRISPR spacer
agctcctacttctttaagtaggagtggttcacaataa	Protospacer
  * ********** ***********.***  .  **

14. spacer 29.14|8359829|37|CP035758|CRT matches to NZ_CP046318 (Campylobacter coli strain FDAARGOS_735 plasmid unnamed1, complete sequence) position: , mismatch: 10, identity: 0.73

ttcgcctacttcttgaagtaggagtgattctggtaaa	CRISPR spacer
agctcctacttctttaagtaggagtggttcacaataa	Protospacer
  * ********** ***********.***  .  **

15. spacer 19.6|4437471|34|CP035758|CRISPRCasFinder matches to NC_042014 (Arthrobacter phage Piccoletto, complete genome) position: , mismatch: 11, identity: 0.676

tacgccgggcgctagccagcctagcagtattaac	CRISPR spacer
ccagtgtggcgcgagccagccgagcagtatttcg	Protospacer
.  *.  ***** ******** *********   

16. spacer 29.14|8359829|37|CP035758|CRT matches to NZ_CP046318 (Campylobacter coli strain FDAARGOS_735 plasmid unnamed1, complete sequence) position: , mismatch: 11, identity: 0.703

ttcgcctacttcttgaagtaggagtgattctggtaaa	CRISPR spacer
agctcctacttctttaagtaggagtggttcacaatat	Protospacer
  * ********** ***********.***  .  * 

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	861295 : 875577	7	Liberibacter_phage(33.33%)	NA	NA
DBSCAN-SWA_2	2429883 : 2468736	32	Acidianus_tailed_spindle_virus(25.0%)	transposase	NA
DBSCAN-SWA_3	3362951 : 3435333	47	Tupanvirus(60.0%)	transposase	NA
DBSCAN-SWA_4	3448468 : 3500639	48	uncultured_virus(33.33%)	transposase,integrase	attL 3443369:3443383|attR 3503768:3503782
DBSCAN-SWA_5	8739719 : 8747922	7	Tupanvirus(50.0%)	NA	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>CP035758|861295:875577|DBSCAN-SWA
GATGGTTAGCCAAGAATTAAAAAAGACGCTTTGGGCGGCGGCAGATAAGCTACGTTCCAACATGGACGCAGCCGAGTATAAGCATATTGTCCTCGGCCTTATTTTCCTCAAATATGTTTCCGACACGTTTTCTGAACGCCAGACAGAGCTGCGCCACAAGTTCACTGATCCCGATGATGAATATTATCTTCCCGACCAGGACAGCCTGGAAAGAGAACTGGAAGATCGTGACTATTATACGGAGGCCAATGTATTCTGGGTGCCGGAAGATGCACGTTGGGAGAGTATACGCAATAATGCGAAGCAGCCCAACCTGGGTAAGCTGATAGATGACGCGCTCGTTGCCATTGAGACTGAGAACCCTCGCCTGAAGAATATCCTGGATAAACGCTTTGCCCGGACGGAGTTGGAACCTGGCAGGCTGGGCGAGCTGGTTGACCTTATTTCCAAAATTGGTTTTGGGGGAAAGGAAAAAGCTCGTGACGTATTGGGCGAGGTCTATGAGTATTTCCTCGGCCAGTTTGCCACCGCTGAAGGAAAGAAGGGTGGGCAGTTCTATACTCCTGCCTCTGTTGTCAAAGTGATTGTGGAAATCATCGCACCACATAGAGGCAAGGTATATGATCCCTGCTGCGGCTCCGGCGGGATGTTTGTACAGTCTGAGAAATTCATCGAATCTCATGGCGGGAGATTTGGCGACATCAGCATTTACGGGCAGGAAGGCAATCCTACGACCTGGAGGCTGGTGGCAATGAACCTCGCTATCAGGGGAATGGATTTCAACCTGGGCAAAGAGCCTGCTGATAGTTTCACCCGCGATCAGCACCCAGACTTACGGGCGGATTATATTATGGCGAATCCTCCTTTTAATATCTCCGACTGGTGGAATGAAAAACTGACTGGGGACGCACGCTGGGAGTATGGTACTCCGCCTGCTGGCAATGCAAACTATGCGTGGCTGTCACATATTTTGTATCACCTGAAACTTTCCGGTTTGGCAGGCGTCGTGTTGGCAAATGGTTCTATGTCTTCTACCCAGAACAGCGAGGGGGCAATCCGCAAAGAAATGATCGAGCGTGATGTCGTGGATTGCATGGTGGCCTTGCCCTCACAACTTTTCTTCAATACACAGATTCCGGCTTGCCTCTGGTTCCTGGCAAAAGATAAACGCACTAATGGTCGTGACCGGCGCGGAGAAACCTTATTCATTGACGCCCGCAAGTTGGGACGTATGGATACCCGCGTAACTCGTGTGTTTGATAACGAGGATATTACCAAAATTGCAACTGTTTACCATGCTTGGCGAGCAGATAGCGAAACCACAGAAAAATACCAGGACATTCCTGGCTTTGCATATGCTGCTAAAAAAGAGGAGATTAAGGAGAACGGTTATGTTCTTACGCCAGGGCGCTATGTTGGAGCAGAAGAAACTGAAGATGATGACGGAGCTTTTGGTGAAAAGATGGTCTATTTAACACAACAACTAAAAGAACAGATGGAAGAAGGGGAGAGCCTGGACAATGAAATCCGCCAGCAACTTAAGAAGGTGGGGTATGGATTCTGATGAGCGAATACCTATTTAAAGACATTCTGCTAGAAACAAAGGATGGCGAATGGGGAAAAGGAGAACCGGGGGAAGATCTTGTCAGAATGAAGGTTATCCGGGGAACTGATTTTGAGGCCGTCAGAAATTTTCGGCTCGACGACGTTCCAGAACGATTTATTCCTCGCCATATTGCAGAGCGTAAATCTCTCAAGCCATACGATATTCTTCTTGAAACGGCGGGTGGTACGAAAGACCAACCTACAGGCCGTTCTGTGATTCTGAAACCTGAACTTTTTAATAAAACAGATTTGCCTATCACTTGCGCAAGTTTCAGTCGTTTCTTGAGAGTTCATTCTGATATTGCAGACCCAGAGTATATATTCTGGTGGCTTCAATATATGTATGAAAGCAGAAGGATAGAAGTCTTCCATGTACAGCATACAGGCGTTGCACGTTTCCAATATACACTATTTGCAACCACAACAAGTATCAACTTGCCTCCGAACGATGAACAACGCGAAGTCGTAAGGCTTCTTTCCTGCCTTGATAAGAGAATTGAACTGAACCAGCGTATGAATAAGACGCTTGAAGGCATAGCACAGACGCTTTTCAAATCATGGTTCGTGAATTTTGATCCAGTAAAAGCCAAAGCCGAAGGGCGCAAGCCTGAAGGCATGGATGAAGCTACTGTTGCACTGTTTCCTTCAACTTTCATTGAATCCATACTTGGACCTATTCCAAAGGGATGGGCAATAAGCGAAATAGGAAAAGAAGTTGAAGTAGTAGGAGGTTCAACACCGAGCACGCAAGAAGCAGCTTACTGGGAGAATGGTGATTTTTACTGGGCTACACCTAAAGACCTTTCTAAACTAAAATCTCCAATTCTACTTGATACAGAACGTAAAATTACGGAGCTTGGAGTAAGACAAATCGCTTCGGGTCAATTACCTATTGACACGATTCTTCTCTCTTCTCGCGCACCAGTAGGATATATAGCGTTAGCAAAGGTTCCTACTTCGATAAATCAAGGTTTTATTGCAATGAAGTGCACCAAAGAGCTTTCTTCATATTTTGTTTTAAATTGGACATACCATACATTAGAAGAAATTAAAGCGCGGGCTACAGGGACTACTTTTGCGGAAATCAGCAAATCTGTTTTCAGACCTATCAAGGTTATAGTTCCCAGCAAATCTATAATCCAAGAGTTTAATAGTATTGCCAAACCAATTTACGATAGAATAGCAGAAAATGATCTCAACATATCTTCTTTAATGAATCTTCGCAATTTACTACTTCCTCGCCTCATCTCTGGCAAACTGCGGGTAGACAAGGTTAGTGAAACAGTAGAGGCATTGGCACTATGACACACATCACGGAAGATCAGCTTGAACAAGCGGCATTGGGCTGGTTCCGGGAACTAGGCTATCAGGTGGTCTTCGGCCCGGACATAGCCCCACCGCCAGACGGAACTGCACCTGAGCGCGATAATTACCGCCAGACCATCCTTATGGAGCGCCTGAAAACCCGGCTCCAGATTATCAATCCGGCCATTCCTGCGGCTGCCATAGATGATGCTATTCACCAGATTCTTGCACCAAACCTGCCCACTGTGATCCAGATTAACCGGCAGTTCCACCACTGGCTGCGCGATGGCGTCAAGATACAATATCAGCGGGGTAACGAGACTGTGGGTGATCAGGTCTATCTGGTGGATTTCACTGAACCGACAAAGAATGACTGGCTAGTGGTCAACCAATTTTCCATTCGAGGCACTCAACATACGCGCCGCCCTGACATTATCGTCTTCCTGAACGGACTGCCGGTAGCCGTGTTGGAGCTGAAGAACCCTGCTGATGAGGAAGCCGATATCTGGAAAGCTTTCGACCAGCTTCAAACCTACAAAGAGCATATCCCCGACTTGTTCAACACCAATGAAATGCTGATTATCTCCGATGGCGTAACAGCTCGCATGGGGTCATTGACTGCCGATAAGGAGCGCTTCTCCACCTGGCGCACCATTGACGGCCACGCTATTGACCCGCTAGGCACAATGAGAGAACTGGAAACGCTGATAAAAGGCGTCTTCAACAAGGAATTTCTACTGGATTACCTCCAGAACTATATCCTTTTTGAGGAAGATAAAGAAGGAATCGTCAAAAAAATCGCCGGATATCACCAGTTCCATGCAGTACGATTGGCTATGACCAGGACGCTTGCCGCCGCTGCGGTTGACGGCGACCGCAAGGCTGGCGTGGTATGGCATACGCAAGGCTCCGGCAAGAGCATCTCTATGGCCTGTTATGCTGGTAAGGTCATGACGAACCCGGAAATGAAGAATCCGACTATCGTCGTCGTTACCGACAGGAACGACCTGGACGGCCAGCTTTTCGGCACCTTCAGTATGGCAAAGGATTTACTCCGCGAAACGCCAGCACAGGCTGATAACCGCAAAGGCTTACGGGAATTGCTTGCTAACCGGCCATCGGGCGGTATTATCTTTACCACCATCCAGAAATTCACGCCGGGTGAGGATGAGGATAGCTTTCCCTTGCTATCCGAGCGGCATAATATCGTCGTTATCTGTGATGAAGCTCACCGTACTCAATATGGCCTGGAAGCCCGCCTGAACAAAAAAGGCGAGTTTGAATACGGGTATGCAAAGCATATGCGCGATGCCCTGCCCAATGCAACCTTCATTGCCTTCACAGGAACGCCTGTTTCCCAGACCGACCGTGACACGCGGGCGGTATTTGGGCCGGATATCCATGTCTATGATATGGAGCAGGCGGAAAAAGACCAGGCCACGGTTAAAATCTACTATGAGGGACGGCTCGCCAAGCTGGAGCTGAACGATGACGAAAATCTTCGGATTGACGAAGAAGTCGAGGAGCTGACGGAAGACCAGGAGGAAAGCGCGGCTGCAAAGACCAAATCCCGCTGGGCGGCACTCGAAAAACTGGTCGGAACAGAACCACGCTTAAAGCAAATCGCCGCCGATATCGTACAGCATTTTGAAAATAGGCTCAGGGTTATTGACGGGAAAGCAATGGTCGTCGCCATGAGCCGTGACATCTGCGCCCGCCTGTATAATGCTATCATTGAGTTACGCCCCGAATGGCACGATGATGACCCCAAAAAGGGTGTCATAAAGATAGTTATGACAGGTTCCGCCAGCGATAAAGCCATCTTGCGCCCTCATCTGTACTCCAAGCAAGTCAAAAAGGATTTGGAGCAACGGTTTAAAGACCCTGGTGATCCCTTCAAAATCGTCATTGTGCGGGACATGTGGCTTACAGGCTTTGATGCACCCTGCCTGCATACCATGTACATTGATAAGCCCATGCGTGGGCATAGCTTAATGCAAGCCATAGCCCGCGTGAATCGTGTCTTTAAGGATAAACCTGGTGGTCTGGTTGTCGATTATATCGGCATCGCAAACGAACTGCGTGAAGCGCTGAACGAATACACTGCCAGTGGCGGAAAAGGGGAGCCAACGGAAGTTATTGAGAAAGCCTTTGATTTCTTCCTTGAAAAACTCAGCGTAGCGCGTGGCATGATGCATGGCTTTGATTATTCGGATTATGAAACCGATGCCTTTGAGCTATTACCTGGCGCGGCGGATCATATCCTGGGTCAGAAAGATGGGCTGAAACGCTTTGCCGATTGCGTCAGTGCCATGAGCCAGGCGTTTGCCTTATGCAGTACCTATGAAGACGCGATTCCACACCGGGAAGAAGTGGCCTTCCTGCAAGCCATTAGAGCCGCTATTACCAAGCACGACACCGCATCCAGCAAAATTGATGATGAGCGGCGGGAACATGCGCTCAGGCAAATTGTCAGCAAAGCGATTGCCGCAGACGGAGTGGTGGATATCTTCGCAGCGGCAGGGCTGAAGAACCCGAATATCGGACTTTTATCCGATGATTTTCTCAATGATGTACGCCTGCTTCCTCATAAGAATCTGGCGGTGGAGCTGCTGGAACGACTGCTCAAGAATGATATTCAATCCCGTTTTAAGAACAATGTAGTGCAAAATAAGAAATTCTCCGATCTCTTGCAGCAATCCCTCAACAAATACCGCAACCGCTCTATTGAAACGGCCCAGGTGATCGAAGAATTGATAGCGATGGCCCAGGAATTTAAGGCAGCGGCGGAACGTGGCGAGGATTTAGGATTAAGTGCCGAGGAAATAGCATTTTACGATGCCCTGGAAACAAATCAGGCAGCAGTAAGGGAATTGGGTGATGCGGTGCTTAGGAAAATTGCGACAGAACTCACTACCCAACTGCGTAAAAATATATCGGTTGATTGGTCTGTACGCGATACAGTCAGGGCAAGGCTGAGGCTTTTAGTAAAGCGGATACTACGAAAATACAAATATCCGCCTGATTTAGAGCAACGCGCCATTGATTTAGTGCTCCAGCAAGCTGAAACATTATCGGCAACCTGGGTATAGCTACGGCTACGCCGCCGTTTCGGCCACCCATACCTTTGCTTTGTCCCCCTCGGCGGTCAGGCAATGCATTTTAACTTGCTATCGGCAATTCGGTTATCTGAGTGGTGTAATTCTGGCTTTTCATACTGCGCATCATCTGCCATTCCTGTTTTATGCCTGCTGCCGCATAAAACAGGGTATTGTCTCCGTACTTCCTGTTTACTTTATCGAGAGCAATCATAATCGTTTCCTGCTTCTTCTCATCGTTGGAAGTTAACAGGTCAAACTGCCGCTGACTTGCTGGCTTAAGCTCTAACAGTATGATACCGCCCTTGCGGTAGCGGTAGCCCGCCTTAAATATCTTCCTCACTGCCGAAACGGTCGCCTTTATAATATCGGGTGTATAACAGGTTTCTTTCGGCAGATTTACCACACAGGACGGATGATACTGTGCGCCGTTGAATCTGCTGGTTTCAAAATAAACAAGTATATCCCTGGTAACTTCCTTCTGCTCCCGCAAACGTTCCGCTGCGCGTGTAGCATAGTATGTCATCGCCTCTTCCATATCCTTAAGCGTGGTTATGAAATAGCCGAAGGAACGGGAACATATTATCTGCTGCTTTGCTGGCGGCTGTGCTTCAAGCGGGATGCAGGGTATACCTTTTAGCTCATATACCATACGCAGGCCAGTTATCGTCATCTTCTTGCGTACCCAACTATCAGGCATGTTTCTTAGTTCCCAGGCGGTGCGGATGCCCCTTTGCAGGAGCATTTCAAGCCGCTTATTTCCTACTCCCCATATATCCTCTACCGGAAAGCTTCTTAATGCCTCCTCGATTTTCTGTGGGGTATCGAGCAGGACAACCCCGGAGCTTTTCTTGGCGATCTTATTCGCAACCTTTGCCAGTGTCTTTGAAGGGGCGATGCCGACCGAAACAGGGATATGCGTCCATTTTTTTACCGTGTCACGGATGGTATTTCCGTAGGCCAGCAGATCATAACTCTTGAATGCTTTCAGATCTGCAAAGACTTCATCAATCGAATAAATTTCAATATCAGTGGTCAGCTCGCGCAAAGTCTGCACCACACGGCGGCTAAAATCGCCGTATAAGGTGTAGTTGCTGGAGAACACCGCCACATTGTGCTTCTTCAGCACATCCTTGATTTCAAAATAAGGCATTCCCAAATCAAGGCCAAGTGCTTTTGCTTCATTGCTCTTGGCTATCACCATACCATCGTTGTTAGAAAGCACCACAACCGGCTTGCCGTTTAGCTTGGGCTGAAACACACGCTCACACGACGCATAGAAATTATTGCAGTCGATAAGGGCGAACATAAGCCTTATTCCAGAGTGGGTATTTTAAAGGGCTTGGTATTGCGGGATTGGGTCTTGCGTATTAATCCATCGTAGCGACCAAAAATACTGAAATCCATTTCCTCGGTTATCTTGATGGGTTTGAATTCAGGATTGGCAGGCACTAGCCATACCTGGTTTTTCACTTTGCGATAATACTTGCACGTATATTCACCCAGGACGGAAGCGACGACAATATGGCCGTCCTGTACCTCCAATGCGCTATCGACAATAATAATATCGTCATTGAATATTCCGGCTTCTATCATGGAATTGCCACCAATTCTGAAGAGGAACACCGAAGCGCGGCGATGCCCCAGCATGAAGTTAGTTATATCAAGCTCTTGCTCCATGTAATCCTGGGCAGCAGAGGGATAACCGGCAGGCACCTGAAATATGGGCCGGAGGACAGGCGCGGAATATACCGGCTTCAATAGCGTTGCCGTATCTAACGGTCTAGCTACAGAGAGTTTATGCATATGATGTCCTTGTTGCTGGGGCTATTTACCGCCTTGCTGACTTTCCATGATTGCATCAAAGAAGCAGGGAACGGTTCCACCAGCAATTTCAAAGTTTCGACGGTAGAATTAGGAGCAAGCCATTGATAGACGGCATTATGACCTAAAATAACAGGCATTCTGCCATGTATGGGCTGCACTAACTCATTAGCACTTACGGTCAGTATTGTAAAGCAAAGGCCAGTTCTGCCTTGCATCCATAATCCTGCAAAAGAAAAAATTCCCTGCTTAGGGCTGAAATAATAAGGCTGCCTGTCCTTTGGGCTAACTTTCTCCCACTCATAAAATCCATCGGCGGGAATAACGCAGCGTCTAAACTTGAAATCCTCTCTGGTAGCCGCTTTCTCGGATTGGACGTTTAACAGGAGAAATGACTTGCCCTTTATGGTCATAGGCATACCGAATCTGGCAAGTTTCAGCTCCCTTTCCTGGGAGGTAGTTTCGATAATGACCGGAGCGAGTTCTGTGGGCGCTATGTTGTAACTACCAGGCCATTCTATATTGCCTTCGGCTGCATAGAGTTGTTTTAACTCCGTAATCTTACGAGCCTGCCCAAAGCGACCGCACATGGCTTAATTCCATCTTCTTTATTCTTTAGTAGAATAGCACGGTATCAGGAATGAACTTAAAGAAGCGATTAACATTTTTTTTATAAAAAATATAATCCAATTTCAGCACGCAGCAATAACTGTCATGAAATAGTCGTCATTATGAGGTATATCCCCTTAGCCTACGCCGCCGGTTCCGCCACCCTTGCCCTAACTTTTCCGCGCCCGGCTTCCAGACGGGACACATAGCCTTCCTGGGCTTTCTCTTCCTCCTCCTGCGGCGCATTGTCGTTGGCCGCTGCGGCCTGCACGTCGCCCTTGTCGAGGTCAAGTTGTTTGTTGATGTCCTGCTGCCTGACGAATAGCTCGCGGAGCTTTTCCTCATGCTCAAAGGGACGCGTGAGCTGTTCGCGGAAATCGGTAAGCGCCTTCTCCATGCGCCCGCAGGTGGCCTGCTCCTTTTCGGCGTCCCGGTCAAGATTGCGGAGCGCGTGTTCGATGCTCGCTATGGTGCCGAGCGGGTTTTCCGGGTTGAAGTTGACTTCATAATAGGCGCTCGCGCCGCGCAGGTACAACTCCGGCATGCCGCCTTCGCGCCGACTCGGCCTGCTCCATATCTCAAAGCCTTTGGTGTGGCCGCGTGACATCAATTTCTCGCTGTCCTCCCAGAGCGCGGATGTGATGGCCTGAGTAAGCGCCTTGCCCGCTTCCTCGCGGGCGTTCTTGCCGGTATATTCCTTGTCTCCTATGGTCATGGTGAATTTCTCTCCCCCATGCGCATCGCGGGTGGCGATGTCGGCGCGTAGTGCGGCAAGCGATTGCTTGACCCGTTCAATCCGTCCGGGCAAGGCTCTTACTTCCTGGCCGATTTCATACTGCTGGTTTATATGTGCCGCCCGCAGCATGTCGAGCCTGCGCACTTCGGTATCAATGCGCACCTTCTCCATCACTGCCGGATTGCCGGAGGCGATGGCCTTAATTTCTGCAAAGTTCAGGGCGCTGCTCTCCAGATCCTCCGCCTCGCGCACGGTGACATCGCCGCTCATAATCTGGCTGATGAAGCGCTGCTTCGTCTCTAGCGTCTGCCACATATAGGCATCGAACGAGCCTTCGGTGACGTAGCGGTAAATCTCCACGCTCTCGTTCTCATTGCCCTGACGCAGGATACGCCCGTCGCGCTGTTCCATGTCGCGGGGACGCCAGGGGCAATCCAGGTCATGCTTGGCTTTCAGCTTCTTCTGGACGTTGGTGCCTGCGCCCATTTTTTCAGTGCTGCCCAGCAGGATGCGGACGCGCCCGGCATTGACCGCATCGAACAGCGTCTTTTTCCTGGCGTCGGTATCGGCGTCATGGATAAAGGCGATTTCTTTTTCCGGGATGCCGCGTGCTATCAGGTGGGTTTTGATTTCGTCATAGACGTTGAACTTCCCCGGCGCGGGCGTGGACATGTCGCAGAACACCACCTGTGTTGACTTTTTACCGGCGGTGGTTTTCCAGATGCGGAAGATATTATCAATGGCCTGTCTGACCTTCGTATCCTGGCCCGCGCCGTTTTCCTGGCCCACCAGGCGCATATCGAGCGCGGCTTTCCTGCCGTCGCCCGTGATTTTGAGCATGTTGTCGATCCACGGGTCAACCGTGCCCTGGCGAATCAATTTCGCTCGCCTGACCAGACCGGAGACATATTCTTTCAGCGCTGGTGACGCAGGGGATACCATCACCTGTGGCTTGCCGCCTTCGAGCTTCGGACGCGGCAGCTTCAGCATCTGTGCCGTCTGGATGTCGGCGAAGGTGCGAAACTGTGAAAGCAGCTCAGGGAGGTTCACGAACTTGGCGAACCGCGTATTCATCCGGTAGCCGCTGCCGTCCGGGGCCAGCTCCAGCGCGGTCACGGCTTCCCCGAAGTTCGCGGCCCAGGCGTCAAAATGCGCTACCCCTGCCGCTTCCAACTGCTCCGGCGCAAGGTAGCGCATGAGCGTGTACATCTCGGCCATCGTGTTGCTGATGGGGGTGCCGGTGGCAAAGGTGATGCCACCGCCGCGTTCGCTGACATACCGGGTCTTCATGAACATATCCAAAGCCCGGTTGCTCTCGCTATTGGGTATTCCGGCCAGCCTGCCCATCTTGGTCGTAAAGCTCAAATTCTTGAAAAGATCAGCTTCATCCACAATAATCTGGTCAATGCCCAGCTCCTCGAACGTTACACCGTCGTCCTTCTTCTCGCGCCCGGCGCGGTTCTTGATTTTGGCCTCCAGGCGTTTCTTGGCTTTTTCCAGGTCTTTGACTACGGAACGGTTGCCGCCGCGATCCGCCTTCGCTTCCAGTATGGCATCCTCTAACGCATCCAGTTGTTGCTGGACGAAGCGCTGGAAGGTTCTGTCGGCAACAGGAAGCTTTTCAAAGGACTTGTGGGAGAGTATCACCGCGTCATAGTTGCCGCTGGCGATACGCGCCATCGCCTTTTCGCGCTTGCCCTCCTCAAAGAATTCCTTGCCCGCCACAAAGATATTGGCATGGGGATAGAGCTGGAGGAATGCCGCGCCCCATTGCTCCACCAGGTGGTTCGGCACGACAATCATCGGCTTGGAACGTAAGCCCAGACGCTTTAATTCCATACAGGCGGCGGTGCAGGTGGCCGTCTTGCCCGCGCCCACACAATGGCCGATGAGCGCGTTCCGGGTCTGTAAGATGCGCCATACGGCGTTTTTCTGGTGAGGGTCGAGGTCATTACCCCTGAGTCCCACCCGGTTCATGCCGGGGAGCGTCAGGTGTGAGCCGTCATAGGTACGCAGACGAATGTTATTGAAGCGGTCGTTATAAGCCCTAGCCAGGCGCTCGGTGCGTTCCGGGTCTTCCCATATCCACCTGGCGAAGCGGTCTTTGAGCTTCTGCTGCATCTCGCGGGCGGCAATGGTTTCCGTCTGGTTGACGGTGGTTTTTCCATCGGCATCCGTATCTTGGATGGTGGGCGTCTTCATATTGAGCGCCGTCTCCACGAGCGATGCCGCGTCCATGCGCCTTGTGCCCCAGGTGGTGCTGTTGCTCACCGATTGCGCGGCGTATTGGCCTAAATCCACTGACCAGGTAGCGATCAGCCCGGAATGCCCGACCTTCACCTGGTCTTGGGACACCTGGAGCAGCCCGGCAATAAAATCACGGATGTCGTTGCGCGGTATCCACGATGCGCCCAGCCTCGCGTTGATGTCGCCCGGCTGGATGTCGGGCGGCTGCACTTCTTTAAGCGCAAGGACATTGGGGCGGTATTGTGCGTGAAGCCCGGCAGCGTCTTCCGCCACTTTGAGCTTCCTGCGCACATCGCCGCTCAGATACTCGTCCGCCGTTTCCCAATCGCCTTCGGGATTGAGATAAACCTGGCCTTCGAGTTCCGCCTGCATCACCTTGACGCTGTTGCCGGTCAAGGATGCCATGCGCTGCCAGTCAATCGCGCCGGTTTCGTTCAACGAAATAGCCAGGGCCTCCGAGGCGCTTTCGACATGCTCCAGCGGCTTCGCCCGCTGCAAGGTGCGCTGCGTGAAGATGAGCGTCTTCGCGGCGGATTTCTTTTCGGCGTTGTAATCTTCGAGGGAAAGCAGGAGGGGGTGGTCGGGATCGCAGGTGAACACCCGGAGGTTTTCTTTGTCGTGGATGCAGCCATATTGCCTGGTGAAGCGGTCATAGGCCCGGTTGAGTTCAGCTCTGGCTCTCGTGATGGCGGCATCCGGTGCATCGTCGAGCTGCGTTCGGAACACCTCGCGCACCGCATCACGCACCTGCATCAGGCCGCGCACTCTGGCGCTCGCGGAAGCGGAGAGGGCGGTAGGAGTGAAACTATGGCCGGTGCGGATGACAATCTTGCCGTCTACTTGCGTATAGGCACCGTCCTTAACGCCGCTGAACGCTTCCGGGTCGGCAATCGGTAGGGCAGGCGGCGACCGGCCTTTCGCACGGGGAGTCAGCACGCCCCCCGGCAGCGCCCGCATGGCTGCTTCCAGTTTCTCCGGCGTGAGTTCGCCGGAGAGCGTCAGCTCCTTGTCACGGTGCATCGAGCCTTTAAGCGTCAGCTCGCCCAGCATCCTCTCCGGGTGGTGGATGTAATACTCATTCAGGAACACCTCGCGGCCTTCCACCTTGACGGTCTGGCTTTCTGTCCATGCTTCGCCTGCCGCTTCCTTCCCTGCGGCTCTTTTGCGCAAAAACAGGATATCCGTCACCACTTCCGTCCCGGCGTTGCCCTTGAAGGCGGTGTTCGGGAGCCGTACCGCGCCTATCAGGTCTGCTTGCTGCGCCAGGTGTTTGCGAATAATATCGTCTTTCTTATCCATCGTGTAGCGGCTGGTCACAAGCGCCATGATGCCGCCCGGACGGAGCTTTGTGAGCGTCTTCGCAAAGAAATAATCGTGAATAGGATGCGTGAATTTCTTCAGCTTCTCGTCCGGGTCATGCACGCCATAATCCCCGAACGGCACATTACCGACCGCCACATCGAAGTAATTATCCGGTAGCGCGGTTTCCTCAAATCCTTTATGAAATATCCTAGAATCTGGGTAGAGCTGCTTCGCAATCCGCGCCGTGAGGGAATCGAGTTCTACCCCGGTTCTCTGGCAGCCCTGCAAGCTTTCCGGCATCAGCCCAAAGAAATGCCCGATACCCATTGAAGGTTCCAGCACGCACGCATCCCGCTTGACGCCCAGCTTTTCCAGCCCCTTCCATATGGCCGTAATCACCAGGGGCGACGTAAAATGCGCGTTCGGGGTCGTGGCCTTTGCGGATCGGTATTCTTCCTCTGTCAAAAGCTGCTGCAACTCTGTGGCGGGGACTTTCCATTCCGGTCGGAGCTTCCATTCCGGCTCAAACACCTGTGCAAGTGCTCCCCAACCGGAATAACGCACCAGCACGGCCTTTTCCTCGGTCGTAGCCTCGCGGTTCTCGGCTTCGAGGGTTTTGAGGCACCGGATGGCGGCGATATTGGCGCGAGCCTTTTCATGGAGTCCCCCGGAACCGACACCGTGCGCCTCCGTGATGCGGAAATCGCGGGAGGGCGTTAGCTCGGATTCGGGTTCGTCGAGGACGATTCTTCTTCCGGCAGAAAGAACTGATTCACTATCATCTCCCTGGCTGCCGGGTAGCTCATCTTCTTCACCGCTATCAGCTCGTACTCCAGGTCGGTGATGTGCTGCGCTGTCCTCTCCAGCTCCGTTGCCAGGCGGTTCTCCTTCTGGAATTGCGCCAGCAGTTTCGGACAATGGTTCTGCCAGTGCGTCAAAATCTGGTTGCTCAGGGCGTCGTGGCTGTGCTTGCTGTCTGGGTTCTGGTCGCTCATAGGCTAGCTCTCCTTCCAGGGTTGGGGTTGCGGACGTTGCCGCCTCGCCGGAGGCGGCAAACAGCGTAGGTTGCTCCATACCTTCCGGCAAGCCGGTTTTCTTTTTTTCCTTCGTGCGCCTGCGCGGCGCGGGCCGGTAGACCTCTTCGGGTTGCTGGCTGGCTTCCGGCTCCGGCCAGGCAAAAGGGGAGGTGCTGGCGAAAAGATCATCCAGGGTGAGTTGTGTAGTGCCTTCGGGCAAGACGGTGGATTTCTTCGTCTTTCTGCGGCCTCGCGCAGCACGGCTTGCCGCGCCGCCATTGCAGAGGGAAGATTTCCAGCTTCCGGCGTCCGGTTCCTGTTCCGCGAGCGCGAAAAAATCAAGCTGGCTGACCTGGCCGGGAGGCGCTACATAGGATGACCGTGCTTCTATGGCAGGGACGGGGAGGGGAGTCGGTTGTGCCTGGATGTCAGGAAGCGAGAAAAGCGTCTCCAGTCTATGCTGCTCCAAGCCCACCGGCAATGCGCGGGATTTCCTTTTCTTGCGGACGGGTGGCGTTTCAGGCGGAGCAGCGACAGCCAT

Protein sequences of DBSCAN-SWA_1

>CP035758|861295:875577|869089_869716_-|QBD75178.1|DBSCAN-SWA
MCGRFGQARKITELKQLYAAEGNIEWPGSYNIAPTELAPVIIETTSQERELKLARFGMPMTIKGKSFLLLNVQSEKAATREDFKFRRCVIPADGFYEWEKVSPKDRQPYYFSPKQGIFSFAGLWMQGRTGLCFTILTVSANELVQPIHGRMPVILGHNAVYQWLAPNSTVETLKLLVEPFPASLMQSWKVSKAVNSPSNKDIICINSL
>CP035758|861295:875577|864209_867296_+|QBD83366.1|DBSCAN-SWA
MTEDQLEQAALGWFRELGYQVVFGPDIAPPPDGTAPERDNYRQTILMERLKTRLQIINPAIPAAAIDDAIHQILAPNLPTVIQINRQFHHWLRDGVKIQYQRGNETVGDQVYLVDFTEPTKNDWLVVNQFSIRGTQHTRRPDIIVFLNGLPVAVLELKNPADEEADIWKAFDQLQTYKEHIPDLFNTNEMLIISDGVTARMGSLTADKERFSTWRTIDGHAIDPLGTMRELETLIKGVFNKEFLLDYLQNYILFEEDKEGIVKKIAGYHQFHAVRLAMTRTLAAAAVDGDRKAGVVWHTQGSGKSISMACYAGKVMTNPEMKNPTIVVVTDRNDLDGQLFGTFSMAKDLLRETPAQADNRKGLRELLANRPSGGIIFTTIQKFTPGEDEDSFPLLSERHNIVVICDEAHRTQYGLEARLNKKGEFEYGYAKHMRDALPNATFIAFTGTPVSQTDRDTRAVFGPDIHVYDMEQAEKDQATVKIYYEGRLAKLELNDDENLRIDEEVEELTEDQEESAAAKTKSRWAALEKLVGTEPRLKQIAADIVQHFENRLRVIDGKAMVVAMSRDICARLYNAIIELRPEWHDDDPKKGVIKIVMTGSASDKAILRPHLYSKQVKKDLEQRFKDPGDPFKIVIVRDMWLTGFDAPCLHTMYIDKPMRGHSLMQAIARVNRVFKDKPGGLVVDYIGIANELREALNEYTASGGKGEPTEVIEKAFDFFLEKLSVARGMMHGFDYSDYETDAFELLPGAADHILGQKDGLKRFADCVSAMSQAFALCSTYEDAIPHREEVAFLQAIRAAITKHDTASSKIDDERREHALRQIVSKAIAADGVVDIFAAAGLKNPNIGLLSDDFLNDVRLLPHKNLAVELLERLLKNDIQSRFKNNVVQNKKFSDLLQQSLNKYRNRSIETAQVIEELIAMAQEFKAAAERGEDLGLSAEEIAFYDALETNQAAVRELGDAVLRKIATELTTQLRKNISVDWSVRDTVRARLRLLVKRILRKYKYPPDLEQRAIDLVLQQAETLSATWV
>CP035758|861295:875577|861295_862858_+|QBD75175.1|DBSCAN-SWA
MVSQELKKTLWAAADKLRSNMDAAEYKHIVLGLIFLKYVSDTFSERQTELRHKFTDPDDEYYLPDQDSLERELEDRDYYTEANVFWVPEDARWESIRNNAKQPNLGKLIDDALVAIETENPRLKNILDKRFARTELEPGRLGELVDLISKIGFGGKEKARDVLGEVYEYFLGQFATAEGKKGGQFYTPASVVKVIVEIIAPHRGKVYDPCCGSGGMFVQSEKFIESHGGRFGDISIYGQEGNPTTWRLVAMNLAIRGMDFNLGKEPADSFTRDQHPDLRADYIMANPPFNISDWWNEKLTGDARWEYGTPPAGNANYAWLSHILYHLKLSGLAGVVLANGSMSSTQNSEGAIRKEMIERDVVDCMVALPSQLFFNTQIPACLWFLAKDKRTNGRDRRGETLFIDARKLGRMDTRVTRVFDNEDITKIATVYHAWRADSETTEKYQDIPGFAYAAKKEEIKENGYVLTPGRYVGAEETEDDDGAFGEKMVYLTQQLKEQMEEGESLDNEIRQQLKKVGYGF
>CP035758|861295:875577|868616_869108_-|QBD75177.1|DBSCAN-SWA
MHKLSVARPLDTATLLKPVYSAPVLRPIFQVPAGYPSAAQDYMEQELDITNFMLGHRRASVFLFRIGGNSMIEAGIFNDDIIIVDSALEVQDGHIVVASVLGEYTCKYYRKVKNQVWLVPANPEFKPIKITEEMDFSIFGRYDGLIRKTQSRNTKPFKIPTLE
>CP035758|861295:875577|869877_875577_-|QBD75179.1|DBSCAN-SWA
MAVAAPPETPPVRKKRKSRALPVGLEQHRLETLFSLPDIQAQPTPLPVPAIEARSSYVAPPGQVSQLDFFALAEQEPDAGSWKSSLCNGGAASRAARGRRKTKKSTVLPEGTTQLTLDDLFASTSPFAWPEPEASQQPEEVYRPAPRRRTKEKKKTGLPEGMEQPTLFAASGEAATSATPTLEGELAYERPEPRQQAQPRRPEQPDFDALAEPLSETAGAIPEGEPPGNGAGEDSAAHHRPGVRADSGEEDELPGSQGDDSESVLSAGRRIVLDEPESELTPSRDFRITEAHGVGSGGLHEKARANIAAIRCLKTLEAENREATTEEKAVLVRYSGWGALAQVFEPEWKLRPEWKVPATELQQLLTEEEYRSAKATTPNAHFTSPLVITAIWKGLEKLGVKRDACVLEPSMGIGHFFGLMPESLQGCQRTGVELDSLTARIAKQLYPDSRIFHKGFEETALPDNYFDVAVGNVPFGDYGVHDPDEKLKKFTHPIHDYFFAKTLTKLRPGGIMALVTSRYTMDKKDDIIRKHLAQQADLIGAVRLPNTAFKGNAGTEVVTDILFLRKRAAGKEAAGEAWTESQTVKVEGREVFLNEYYIHHPERMLGELTLKGSMHRDKELTLSGELTPEKLEAAMRALPGGVLTPRAKGRSPPALPIADPEAFSGVKDGAYTQVDGKIVIRTGHSFTPTALSASASARVRGLMQVRDAVREVFRTQLDDAPDAAITRARAELNRAYDRFTRQYGCIHDKENLRVFTCDPDHPLLLSLEDYNAEKKSAAKTLIFTQRTLQRAKPLEHVESASEALAISLNETGAIDWQRMASLTGNSVKVMQAELEGQVYLNPEGDWETADEYLSGDVRRKLKVAEDAAGLHAQYRPNVLALKEVQPPDIQPGDINARLGASWIPRNDIRDFIAGLLQVSQDQVKVGHSGLIATWSVDLGQYAAQSVSNSTTWGTRRMDAASLVETALNMKTPTIQDTDADGKTTVNQTETIAAREMQQKLKDRFARWIWEDPERTERLARAYNDRFNNIRLRTYDGSHLTLPGMNRVGLRGNDLDPHQKNAVWRILQTRNALIGHCVGAGKTATCTAACMELKRLGLRSKPMIVVPNHLVEQWGAAFLQLYPHANIFVAGKEFFEEGKREKAMARIASGNYDAVILSHKSFEKLPVADRTFQRFVQQQLDALEDAILEAKADRGGNRSVVKDLEKAKKRLEAKIKNRAGREKKDDGVTFEELGIDQIIVDEADLFKNLSFTTKMGRLAGIPNSESNRALDMFMKTRYVSERGGGITFATGTPISNTMAEMYTLMRYLAPEQLEAAGVAHFDAWAANFGEAVTALELAPDGSGYRMNTRFAKFVNLPELLSQFRTFADIQTAQMLKLPRPKLEGGKPQVMVSPASPALKEYVSGLVRRAKLIRQGTVDPWIDNMLKITGDGRKAALDMRLVGQENGAGQDTKVRQAIDNIFRIWKTTAGKKSTQVVFCDMSTPAPGKFNVYDEIKTHLIARGIPEKEIAFIHDADTDARKKTLFDAVNAGRVRILLGSTEKMGAGTNVQKKLKAKHDLDCPWRPRDMEQRDGRILRQGNENESVEIYRYVTEGSFDAYMWQTLETKQRFISQIMSGDVTVREAEDLESSALNFAEIKAIASGNPAVMEKVRIDTEVRRLDMLRAAHINQQYEIGQEVRALPGRIERVKQSLAALRADIATRDAHGGEKFTMTIGDKEYTGKNAREEAGKALTQAITSALWEDSEKLMSRGHTKGFEIWSRPSRREGGMPELYLRGASAYYEVNFNPENPLGTIASIEHALRNLDRDAEKEQATCGRMEKALTDFREQLTRPFEHEEKLRELFVRQQDINKQLDLDKGDVQAAAANDNAPQEEEEKAQEGYVSRLEAGRGKVRARVAEPAA
>CP035758|861295:875577|863238_864204_+|QBD83365.1|DBSCAN-SWA
MYESRRIEVFHVQHTGVARFQYTLFATTTSINLPPNDEQREVVRLLSCLDKRIELNQRMNKTLEGIAQTLFKSWFVNFDPVKAKAEGRKPEGMDEATVALFPSTFIESILGPIPKGWAISEIGKEVEVVGGSTPSTQEAAYWENGDFYWATPKDLSKLKSPILLDTERKITELGVRQIASGQLPIDTILLSSRAPVGYIALAKVPTSINQGFIAMKCTKELSSYFVLNWTYHTLEEIKARATGTTFAEISKSVFRPIKVIVPSKSIIQEFNSIAKPIYDRIAENDLNISSLMNLRNLLLPRLISGKLRVDKVSETVEALAL
>CP035758|861295:875577|867366_868620_-|QBD75176.1|DBSCAN-SWA
MRLMFALIDCNNFYASCERVFQPKLNGKPVVVLSNNDGMVIAKSNEAKALGLDLGMPYFEIKDVLKKHNVAVFSSNYTLYGDFSRRVVQTLRELTTDIEIYSIDEVFADLKAFKSYDLLAYGNTIRDTVKKWTHIPVSVGIAPSKTLAKVANKIAKKSSGVVLLDTPQKIEEALRSFPVEDIWGVGNKRLEMLLQRGIRTAWELRNMPDSWVRKKMTITGLRMVYELKGIPCIPLEAQPPAKQQIICSRSFGYFITTLKDMEEAMTYYATRAAERLREQKEVTRDILVYFETSRFNGAQYHPSCVVNLPKETCYTPDIIKATVSAVRKIFKAGYRYRKGGIILLELKPASQRQFDLLTSNDEKKQETIMIALDKVNRKYGDNTLFYAAAGIKQEWQMMRSMKSQNYTTQITELPIAS

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBD75175.1|861295_862858_+	SAM-dependent DNA methyltransferase	A0A220A2U5	Liberibacter_phage	6.6e-49	29.7
QBD83365.1|863238_864204_+	restriction endonuclease subunit S	NA	NA	NA	NA
QBD83366.1|864209_867296_+	type I restriction endonuclease subunit R	A0A220A398	Liberibacter_phage	2.7e-70	28.8
QBD75176.1|867366_868620_-	Y-family DNA polymerase	I6RSM4	Salmonella_phage	3.6e-90	45.9
QBD75177.1|868616_869108_-	translesion error-prone DNA polymerase V autoproteolytic subunit	A0A1W6JNS2	Morganella_phage	2.1e-17	39.3
QBD75178.1|869089_869716_-	SOS response-associated peptidase	V9IQW7	Stenotrophomonas_phage	1.3e-19	34.6
QBD75179.1|869877_875577_-	N-domain protein, SNF2 family	I3PUW5	Vibrio_phage	0.0e+00	39.2

Sequences of DBSCAN-SWA_2

Nucleotide sequences of DBSCAN-SWA_2

>CP035758|2429883:2468736|DBSCAN-SWA
GATGGCAAAACAAGGACAGAAACTCTTACGCGTGGGTGCAGCGGCCCATGAACTGGGTTTACACCCGATGACCGTGCGGCGCTGGATCAAATCCGGGCGTATTCAGGGAGTGCAGGTAGGTCGGGAGAGGCGCATTCCACGTACAGAGATTGAGCGGGTGGTTGGAAGCGTGGATGGTCGGCTGCTCATTCTGTACGGACGGGTGAGTGGACATGGACAAAAAGATGACCTGGATATTCAGCTCCAACGCCTGCAAGTCTGGGCAGCCACTGAACGCAAAGGGCAGGAAACTCTGGTGCTTTCCGATATTGGCTCGGGGCTCAAAGCAACACGGCGTCAGTTGCAACGGCTCCTCAAGCTGGTGTGCGAGGACAAAGTGGCTGAAGTAGCGATTACCTACGAAGATCGCTTAACGCGCTTTGGGCAAGAATATCTTGAAACGCTCTTTGCCTGCTTTGGAGTGACGCTGACCGTGTTAGAGACAGGGGAAGAGAAAACAGCGGAGCAAGAGTTGACTGATGACTTGCTGGCCTTGATCGCCTCGTTGTCGGGACGGCTCTATGGGATGCGCTCTCATAAGCAACAGGCACTCGTCGCCTGCGCAAAGCAGGTGATGGGAGAAGAGGAGTCATGAGGTGGCCAAAACGCAAATGCTGTCCTTCCCCATTCGCTTGCCTGAAAGCATGCAAGCTGGGGCGTTGCGGTTGTTGGATGTTTCTCGCTCCTCGATCAATCAGATCATCAGAGATCTGTGGCCTCAGCTTGAGGTCTTTGCCTCAGATCGCACAGGACCGGCGTGGAAGCAGGTGGAACGTCATCTCATCACTCGCTCTGGCCACGGCAGTCGTCAGGAACGGTGCGAGATGGAGCAGGCAGGCCGTCTGCTGCGTGCGCAAGCCTCGCGCTCCCTACTCTTTGAGACCATCTTGCCGCTGCTCTCGGGGGGCTCATCAAACAGGCCACAGACAAGCGTCCTGCCCACAAAGATTACGGACGCATCAAGGAAGAGGTGCATGCCTTTCGAGCGGCCCAAAAAGGGGCAGGAGACGAGCAGGACGCCTTCCTTGCCATGACCAATCTGCTCGAACAAGCCTGTAATCACTTTCTCAAAGAAGAGGCGTTTCCCACCTCCTATGCCCAGATGCAAGAGCCCCCCATGCTCTCCGTTGGCTGTCTGACCTTCGCGGGCGACGATGGCATGATGCTTGGACAGACGTACCGCGCCCGCATTGACCTCGTGACCTGCTGCGACCTCAGCACGCGACGCGAACTGCATCAAGCAACCCTCGCTCTGCGGCTGCGTTCCCCCGATGAACAGGGCAAGTGGGGATGGACTCCCTGGGTGGAGAAGATCCCTTTGCCTGAAACTCTGTACACCTATCTGGAGCAGAGAGCCGTTCTCCAGGCCCCGACGCTGCGAGAACTGCGTCAGGCCGATGGTGAACGCGTGGCCGTTCTCGATCTGATCCTGGAGGTCCCAGCGCGTCTGGTCTTCCCTCTTGAACAGGAACGCCGCGTGCTCGGATGGGACTGGGGGGTTCGCTCGCTCATCACGGTCTCCATCCTCGAACTGTCCGAAGACTGGCGTGAGAAGCCAGATGCGCCGTTTACCCAGCTCTCACGTCCCCTGTTTTTGGACACCGGAGGGCTGGACGGCAGACAGGCGCGGCTGCGTCGGGAGATTGATCGGCTCAAAGCTTGCAAAGAACGCTATGAACGGCTCATCAGCATCGCCACCCGAACGCACCAGGAGAAACCTACGCCTTTGCCTGCCGAGTACGATGGCTGGCTCAGCCGGGTTCGCGGGTATGAGGAGCGCATTGCGGCGTGTTGGCACAGGTACGAACGCAGAAATCGCGAACTCGCACATCTGGCCTCCAATCTGCTCATCCTCCTCGCGCTGATCTATGACTGCCATCTGATCTGCGGAGAGAACCTGAGTACCCTCAAAACCATCGGACGCGGGCGCGGGGTGCGCGGGCGCTTTCGCAACTGGCGCAATAACTCCATGGTCAGGGGGGAGCTGTGGCGCGTGCTGAAGTATAAATGCCATCTGCTGGGGATTCGCACGCGGCAGGTGGAACCGCGTGGGACGACGCACACGTGCCCACGTTGTCATGAACCAGCGAAAACCTACGCCTCTCCTGCCGCAAGAGATCGAAAAAAGGCCATTGACTGGGGGCCGTTTCTCTGTTGTGCGAACCCGGATTGCCGCTGGTCCGGGGCCAGAGACTATGCCGCGTCTCTGAACATCGCACGGCTGGGCCTCGCCTTTTTGCGCACCGCTCTGAGAAGCTCGCGATACACGTCGTATCGCATGGCCGATGCGTCGGTCAACCCTTGCTCCTATACGGGGCAGGGGGCACTCCTACTGTTGCGAGTGCAAGGGATCAACCCCTGCCCCATCATGGGCAAACAGGTCTACTATGCCGGATGGATACGTTCCATGAGATTATGTACATCCCAAACAACCCAGACCCTTTCTTTGCTTTCTGCATCTCAACTCAGAAAGACCGTGTTGTTGCGTGCATGATGTTCGGATAGTTCTCTGTTTTTGCAACGGTAGCTAGGAGAGATTTTGTAGCCATCGTGAATGGAAGTGCCATCAAATCCAGCGAGGATGCCGATGTCGTTGAGCGCGGATCGGCCCCGGCTGGGATGAGAGCCAAAATGCGTCAACCGAGAAGTCGAGCACACATGCACATACGAATGATGCTTGCGCACACACACGTCCGTTTCATCCTGGTGGATCACTCCAGCCTTGCGCAGCCCCTCTTTGATGCGGGTTTCGACCTCGGTGAGGGCCTGGGAACAGGTGCGTACCCACCCGAGCAGACTTCCCGCCGACACCTGCAGACCAAAGACCTCGCATAGGGGATCATCTGGCCCTCAACCAGATAGACTCCCAGCACTTGGAGGTGCGGGCCATAATACTATGCGCCGCTGCTTTAGCTGGTTCAGTTCAAGAAAGATAAGAGAAGAGCAAATCACTGAACAATAACTCTTACTGACGGCTCCTGGATCGGTAAGAGTGAGGCGGAAAGCTGCGTAGTGCTTGTTGCTATTTGTTTATGGATGTTCTTGAATATATCGATCCCGGTAGAAGGTGATCGGCCTGGAACACCTTCTACCGGGATTTGTTACTGTGTTAGCTATTGCTTTGCAGGCGAGACCCAGCTGGCCTCAGCGGCGGCGTGCGGGGATTCGGCCACGATCTGCATCAGCTCGATGGCGTTGCCATCGGGATCGTTTAACCAGTACTGCCAGTTATGATCAAGTCCCTGCTGCGGGCCGCCGCTGATTGTCAGGCCCCGCTTTTCCAGAGCCTCTAAGGTAGCCGATAGATCATCGACAACCAGGCAGAAATGATTATAGCCAACCTTATCGCCGCCTGCCGGATTTTCACCTTGAGCACCGGGGAATAATTCGATAAACTGATTGGGGGCAACCTGGATATAGACAATCCAGGGAGATGGCTCACCCTCGCGCTCTAGCCGAAAGGCCTCCCGAAAACCAAGCTTATTGCAATAGAAATCGAGAGCTTTCTCAAGGTCGGTGATGCGGAAAGCTACGTGTCCAAGCCCTGTAATCATAGCTGGCTCCTTATTCTTTAAATATGCTTGAGCACTTCTTGTGCTATCTGGATGGCTGTATCTGTCCCTTTATTTTGCGTCGAGACGGCTACGTATATATAGTTATTGCCTTTCTGAACCATGATATCGCCCTTAGACATCTCTATCGCACTATCGCCAACTCCGCTGATGGCCTGGCCGTTAGCTATCGTGGATAGTTCTGTCTGCGGACCAGTGAAGAGCCCAATCCCTACAGTGTCAGTCATTGCTGTCTCGGCTGTGTAGAAACACACTTGCGTGCTCTGGACTCCAGGAATGGTCGGAAGCGGAGGCATAGATTTAGCTGGTTGCATTGACTCACCCATAATCTTGCTCAGTGAATTTACATCTATTATAGTATCACAGGATTGGCCGCCAGATGTAGTTGTGGGCTGGTTAGATGCAGATTGTGCAGAAATGGGCTGGGAGGTAGAGGTATCCGTGGTGGCATTAGAGGTTGGCCCATTATCGGTGGGGGTAGATGCGTTTCCTCCTCCACAGGCAGCCAATAAAATAGCCAGAATGATAACAGGGATGATAGCTATTTGGGGCGGTAGGCGAAAAGTCGTAGGAAAAGAATTGCGAGATTCTCGCAGCATAGTTACGCTCCTTATCAAAATCTTTCAAAAAAGTTATCAAGCTTAGATCTTTTATTATAGAGCTATAGAAGCGAAATAGTAATAAGAAGCACTAGAGAATATTACTTTTAGGAACTATCTTTGTGGAAAAACTTCTAACCAGTTATATGGGAGAAGGCAAAATTTACCTGTGTATTTTTGGGAAAACCAGTACATTGCGTTCTTTACTAGCAAAACCGTTTGAAAAAGGGAACAAAAAGTAACCCATCGCTGACTGACAAAGAGCTGTTCTATAGAGGCCGGCTGCCAGGTTATTGAAGCATTCTTTTCTGGTGCAGGCGGTTCATACTCTCGTCTACGTCGCCTATCTTGAGACCTGTGAGGGCAGCAATGGCTTGAGGAGTCGCTCCCGGCTGATAGGCTCGATAGACCACCTGATCAATTTCGACCTTGCCAACCTCTGAGAGCATGATGGACAGCACTTCGTCAATAAGCTTGCCTGCACTCTTAATGGGAACGTAGCGTCCGCCGCTCGTCCCGGCGATTTGCTCAAAACTTTTCTGCATGGCCTGATTATCACCAATGCCCAGGCTAAAGATCGTAATCCCGCGCTGGCGGGCATTCTGGGCTATAGAAATAACCGTGCCATGCTCGGGTTCGCAAGGGCAGCCCTTGGGATATCTATCGCGCCGATTGCCCCAGCCATGCGGAGGAGCATCGCCGGCCAGCAGGATCACCTTGTGGGCATTTTCGCGCCACTTCATAACGTAGCAGGCGTCATAAAGCCCATCGACGACTGCCTCCGCGCCATCTCCACCGCCGCCTTTGGCATGGGCTTCGTTAAGTGCCTGTTGGAGATCATCTAGCTGTTCCGTGAAGGCGTAGCGGCGCGTGACCCAATTCTTTTCGGTGGCAGGATGGTCGCGATAGAGAACCAGGCCATAGGCCAATTGAGGTTGAACCGGATGGAGAGACAGCTTCTGGACAAAAGCCTGCAGATTTTTGCGCGTCATCTCGATGTAGTCTTGCATGCTTCCGGTGGCATCCATGACAATGCAGAGATCAAGTTGCCTGAGCAGCTCATCGCCCTTGCGCGAAGGGAGGGCCGTGCCTGGGGTGGGTAAATTGTTACCGCAGCGTGCGCAAAATCTTGCGGCTTCTCGATTTTTGCTGCCACATGCTGGACAAAACATAGCTCTCTCCTCCATAAGCGGCTTTCCGGTATTATGCCCATTTTAACATACATGAGCCGTCTAAGACCATATGCTTAGGGAATTTTTAAGGGTGCGGCGAGCTATGCTTTGCCTAGCTTGCAACTATCTCTCGCTTACAGCCAGGCGTACACCCAATCCGATCAGGACGCAGCCACTAATCCAGGCCAGCCATTTGCTCACCTGGGGCAGACGCTGAAGCCAGAGCGAGATGCTGCCGGCGAAGAGCGCCAGGCAGGAAAGGAAGAGAAGATCCATTACTGCCAGCGTTAAGCCTAGCCCAAGCAACTGCTCATGAACATGCCCGATGGATGGACGTACAAACTGGGGTATGAACGCAAAGTAGAAAAGGATGGTCTTTGGGTTTAAGAGATCGTTAAGCATACCCTGGACAATCAGGCGCTTATCAGATGAGACGCTCTTCAGCTCTTTAGTAGCCAGAAATTTGTCCCGATGCCTGATGGTCTGGATACCCAGGTATATGAGATACACAGCTCCTACATATTTAATGACAAGAAAGGCGGGCAAGGAGGCGGCCAGGATGCCAGCCAGGCCAAGCACTGTTAATAGTGTGTGAATTGTCTCCCCCAAAACTATACCGAGCGTCGAAAACAGGCCTGCTCTTCTGCCCTGACTCATGGAGCGGGCCAGCACGTAGAAAATGTCGGGACCGGGCATGACAATGGCAGCCATTGTCGCAATCACGAATAAGCCAAATTGAGTATCAAACATGTAAGTATCTCCTCTCTAGACAATCGAACTACGATGCTGGCACGGCTTAAGACCAGGGCTAGAACGGCGGATCGAAATTGGTTAATGGCGATCCGCCAGATGTAATATATTGTTAGTTGAGATGACGCGCTAAGCTACTTACTGCTGCTGAGAGCCTGCATAGAACTCATCAAGCAAGCGCCTGGTCTCGGTATCTGCCTTGATCGCCTTGATTGCCTGCGCAAGTTGCTGTGCGGCGGCGTCAAGAAGTTGTTCGCCTATCTCTGCCGTCGCCGGACGGGCATCGCCAGCATAGTGTGTGGGATAATCAGCGTACCACCAGATTCCCGTCTGCACGCCCACGGCTTTAAGCGCTTGTAGATGCTCGCGGGCCTTGCTTTCGTCATCGCTGGGAATCTGTTGCCTGGCAACCAGATCAGGTCGGATGGCCAGCATCATGCTGGTTTCGCCTGGGCCAGCGTGTCCATCGCTCGCAGGCTCCCAGGGAACCTCTAGCGCACCTCTGGTATTGGTGTACGGATGGGTAACGTAGATTACATAGTCGCGTGGACCATATAATTGCAACTCGTTGAAGAAGGCCAGCAGATTGCGATTGCCTCCATGCGCATTGACAAGAACTATCTTCTTTAATCCGTTGCGTGCGATCTCGCGACAGACGTTATCGAGCAGGCGCAAGATGAGATCCCCATCGATGCTGATCGTGCCGGGACAGTGGCGCGCCTCTGGAATCTGGGTAAGGATATGATCAGGAAATATGAGCGCGGGCTCTAAGGCTGCGGCCCGCTTCAACAATTCACGTCCCTCATACATATCGGTTCCCAAGGGCAAATGGTGGCCATGCCGCTCAATTACCGATAAGGCAACCAGGCATACACCTTCACACTGCTTAACGGCTGCAGGAAACTGATCGCTGCTCAATTCTTCCCATCGCATGCTTTTGCCTCCTTTATACTATATACGTTGGCGCACTAAGATATATTTCAAGCTCTGGATATGTAAGCGGAAATTGCTGTGTTTCTCGGGCGGTTAGCTTAACTGGAGCCTGGCCAGCTATACGCTCAATCCTTGCTTCGTTCTAGACGAGGGCTATAGCGCGTTTACCGCACGTAGCCAGGCCTGAGCCATCAGGGCATGACCGGCCGGGGAAGGATGCACACCATCGGCGGCCCAGAAAGCCGACTCGCGCTGTGCCGCGGCCTGAGCAAATAGCCCGTCAAAGGGCACGTAGAGCGCGCCATACTCGCGCGCCAGCTTGCGCACTACATCAATTTTTGGGTCCAGATCTTCGCGCCAGGTCTCGCGATCGGCTGACACGGACAGGACAAACGGCTCGCAAAGGATCAAGCGCGCGTTCAGGGCTGCCTTTGTGCGCTCCAGTAAGGAACGATAGACATCCTCGTAATCCTGCGTCGAGGTCGGATCGTTGCTGTCATAACGTCTCCACGTGTCGTTAATGCCAACCAGGATAGAGACCCAGCTCGGATGCAGATCAAGGCAATCTTTCTGCCAGCGCTTTAGCAGATCTTTGGCGCGGTCGCCGCCGATGCCACGATTTAAGAAATTGACATTTTTGCTGGGATAAAGGGCTTGAAACCAGGAGGAAGCTATCATGGCATAGCCTGCCCCCATACTCCGTGGGTCCAGGCGATCACGGCCGGCATCGGTGATGCTATCGCCTTGAAATAGAACTACATCCCCATCATTAAAAAGTGGTGACATGAACATCTCCTTGCCCTAAGTGGGCTAACGCTGGGCGCAGGTATTGCCCAACAATCGGTGGCGCACTCCAATCGCGCAACCAGGCTGTTCGGCATACATGCCCGTGGGCTTAACAAACTGAAATATCTAAGCGAGGGGGCATATGGTGATCGAAGCGCTTTTCCTTGTGCTTGCCCGTATAGAGAATCTATACGGAGAAGGAAGCTATGCCATAATTCCCCATTGCCATAGCTATGAGAGGACTTTACCTTCAGGAAAGGTTGCGATATCTCCTTAAAGAAATAACTCCAGATAGATATTTTGTCTTATAGCCATATTGAAAATGTCCTCGAATCGCGACAATATAGTATTATAATATAAAACCAGGCTGTCAGTGTTGGGCCTGCGCGCTCTCGATCCAATGACCTTGTAACGCAAGAGCCAAGGAGGAACTTGCTACGGTTTGTCCACTGAGTACCTTTGCCTGTCGTTAGGCCTGAACTTCATGCTTTGATATGGTCTATGGCAAGTAGTCAAAGAAGAAAAAGGATAGTGCAACATGAGCGAATCAACCTATCGATCCTCCCGGTATCCCTTTGTGCCTTATAAGCCACCTCGCTTTAGCATAGAAGAGCAGAGAGCCGGTGTTCAGCTTTATTTAAACAGGATGTCACGCCGTCGCACAGTCCGTGAATATTCTGACGAACCCGTCCCCTATGAAATTATCGAGAAGGCTATCCAGGCGGCCAGCCTGGCACCAAGTGGCGCGAACCAGCAGCCCTGGAGCTTTGTTGTCGTCAGTGATCCTGAACTCAAACGCCAGATCCGCCTTGCCGCAGAGGAGGAGGAGAAAGAGAGCTATGAGCATCGGATGTCCCAGGAATGGCTTGATGCGCTGGCTCCCCTGGGTACAGACTGGCACAAGCCCCATATAGAAGAGGCTCCCCATGTTATTGTGGTATTCGCCCAGATCTATGGCTTAGAGACACTGCCAGATGGCACTCAACACAAATACAAACATTACTATGTTCAGGAATCTGTTGGCATCGCTGTAGGTATGCTGCTCTCTGCCCTGACCTTTGCCGGCCTGGCTACTCTGACCCACACCCCCAACCCTATGGGCTTCCTGGGGCAGATCCTTCAGCGCCCGGCCAATGAGCGCGCATTTGTTCTCATTCCGGTGGGCTATCCGGCTGAAGATGCTGAGGTTCCTGCCATCACCAAGAAGCCTCTCGATCAGGTGGCGATACATTTCGAGAAAAAATCCTGACGGTAGTTGCAGAGCGCCAACCGGCAAGTGACCTTCCCTCAATGGCCTGGCTCGAACGATAGTATGAAGCAGTCAGCGATCAACCCATCAAATTGAACAGTGCGGGCGACCATCTCGGTCGTCCGTATCACATTGTCACCTCAGCAGCGCCCCTCCTGTATTACATCCCACAGGGATTGCCAGGCCCAATTATACCTACTTATTCTACTAGACATCAACTCAAAGGTGTACATACCACCTCATCCAGCTTCTCAGCAGGCGTGAGGAGGAGCAGCATCGAGCGGCTGTTTTACCGCTTTTACCTCTCAAGATACTCCTTCCTGAAAAGCATGCTATATCCCCCTTACCCAAAACAAGAGAAATATCCCTGTTCTTCTTCTCTAGTATATAGAAAATGAAGATACATGTCGAGTGAGAAAGTGAAAGGAGTGTCAAGAAAGCGATGATTTCACTTGTTTTGCTTTAACAAAAGCGCTTCCACGTGACATGTAATGAACGGGGATTGTTTGTATGAAAAATAGGTGAAATAGTTCTCTTTCTGTAATACTGTATGAAATCATTGAAAGCAGCTTTTCTTTGCGCAGCGTGACAGCTCACTTCTCTCCTCCTAATTACGGGACATACCTCGGAAGAAGTGCGCGAGTTCCTGGCGACGTTGGAAATCCCGTATCGGGAACTGTTTCCCCAACTGAACTTGCGCCAATGGTCAGGCATCATCTACACCTGGCTCACTCACGCGCTTCTTGATCCAACCAATTCTGGCCGTGCAACGATGGATAACCTGATGTGCGCCGCTTCGGCACGTATTGAATAGCCCCACAGGGGCAGAAAGTTGAGAGCAGATGACTTTCTAGGACACTGACTCTACTTGGCGGGGAAACCCAAAGGGGAAAACAGCATAGTCGGAAAGCGGAGAAGCGCGAAGGTATGTAGCGTAGTTTGTATCCGCAAGTCCTGTGTGTATGGTCAAGCCTAAACTGGCTGAAACCCAGCTTCCAGCGGTGTAATGTTCCGCCCATCGCAGCATACCTGAAGCGATGATGTCGAAATACGTATGGGTCATCAGAACATACGAAACCGCCAGGTTGCAATCCTGGCGTAAACGCTCTCTTCGGCAAGCGACCCCTAACGAAGTGGTAGAAGGAGGCGAACGGGAGACCTGGAGCACACTAGACGTTCGATACGTGCAAATGCGGGATCGCCTACAAGGGGATGACCCTCATGGCGACGGAGTTCCCATAGGAGCCAAATGCTCAGGGTAATGCCTGAGACAGGACGAAGGGGAACAGGCATCGTTGAAGAACCAAAGATAGCGAGGTGCGTGAGATGCGTACAGCCGACACTATCCTCGGTCTCATCAAAGAGAGAGGCAAGAAGGGATTGCCTTTAGAGCGAGTCTGAGCTTGACCCACTTTTGTGGACAGGACCAATGGGTGGTTCAGACCATTCTGTTTTCAAACTGAGAAGGGCTGACGTATCCCAAAGACGAATGAAGACGCTGACGATTGTAAAACACTTCGATCCATTCAAAGATCACTTGTCGAGCTTGCGAACACGTCGCGAAACTGGTGCGATGCACACATTCCCATTTGAGTGTGCTCCAAAACGACTCCATAGAGGCGTTATCGTAGCAATTGCCAGTTCAGCTCATACTCACCACCATTGCCGCCTCGGCTAACGCCTGCTGGTAGCCCAGGCTGGTGTGACTTTCTCCCACGATCCGAATGATGCAGCAGTCCTGGTTGAGGACAACGACGTTGCACTGCCATCTGCAACGCGTGTTGGACGAGTTCCTCATCTTGAACAGCAGCCATCGCCCATCCGACCAGCGAACGAGAGTAGAGATCGAGGACCCCAGCGACATAGAGCCAGCCCTCCTGTGTCCACACCGCCGTCACATCCGTCACCCACTTGCGATTGGGAGCACTGGCCTCAAAATCCTGATTGAGGACATTGGCGGCTTTCTGATGAGCAGGATGTTGCCGTGTCGTGTGAGCACACCTGCCAGGCTCTCGTGCAGACCAGCCCTGTTGCCGGATCAGGCGAGCCACCCGCTTGCGCGAACACCGATGACCTTGCCGTTGCAAGCAGACATGCACGCGTGGACTGCCATAGGTCTCTCGACTCTGTTGGTAGCAGACTTCAATGGCCTCTTTCAACTCGCCATCTTCCCGCTCATGCTGGCTGACTGGGCGCGCTTTCCACGCGTAATAGCCGCTCTTTGAGACGCTCAGCACGCCACACAATCTCACGACCGGATAGTCATGACCCATCTGATCGATGAAGGTATAGATCATCGCTGGGGTTGTGAGAAGATGGCCAAGGCTTTTTTTAAGATATCACGCTCTTGACGTAAAATCTCATTTTTCCGACGTAAGCGGCGCATCTCTTCCTCTTGTGGGGTTTGATGTCCGCTTCCAGGAAACGCATTTTGATCATGCTTTTGTGCCTGCTGTTTCCACCCTTGAAGGGTATTATCTGAGATCCCTAAGTCGCGAGCGACCTGGGCCAGCGGTTTCCCTGTGGTTTCTACCAGATGTAAGGCTTCTCGCTTGAACTCGGCATCAAAGGTCCGTTTCGGTTTTTCCATCGCATATCTCTTTCATGGATAGTATACCTGTCTTCCTTCTGTCCATGAAAGTGGGGCAAGGGCACCCTTCGGCGGAACCAAAGAATTATACAAAGGGCAACAGTTCCCCATGCTCCATTGCAAGATTTTTCCTCCAAGAATGCTGTCTGGTTGTTTGTTCGTGATCCTTCCCAACTCGATGAGAAAGAGCAGATGACTCTCTCGATCATTTGTCAGACAAGCGAGACGACGAAGCAGACGTACCAATTCGTTCAGGAGTTTCGGTGCTTGCTTCATAATCGCGAAGGGGCTAAGCTTGATGACTTGCTAGAAAGAGTCCGAGCAAGTCAGATTCGTGAACTCCAACGTTTTGTCACTGGTGTTGAGCGCGACAAGGAAGCAGTTGTTGCTGGGCTGACCCTTCCTTTCAACAACGGTCTTGTCGAAGGAAAAGTAAACAAGCTCAAGCTGCTTAAAAGGATGGGGTATGGACGTGCAAGCTTTGCATTGGTACGCCAGCGTGTGCTCCACGCTCTTTAATCACGATATATTATATTTTTATCATCTATCACCAAAAGTGGGACAGAACCGTGATATGCGACAAAAACTTGCCTCTTTCATTGATCTCAGGTATACTCTTCATCAAAGGCAGATGACCATGCACAACTTCGCTGGTTAAAACTAGCTGAACAAGAGGTCAATTGGTCTTTGGTGTATTTTTCACGAAAGGGTAGCCACGTGCGATAGAAGGATTCGAGCAGCCAGAAAAAGGAGAGATAAGGATGACACATCGCGCTGGTCAACAATTGGGGAACTATCGACTGACTCACCTTTTGGGGGAAGGTGGCTTTGCTGAAGTGTACTTAGGTGAACATCTTCACCTTGGTACTCAGGCAGCGATTAAAGTGCTCCATACCCAGCTCACAAGCGATGATATCGAGAGCTTTCGTGCAGAGGCGCGAACGATTGCTCACCTTATCCATCCACATATTGTACGAGTACTCGAATTTGGTGTAGAGGGCAAAACTCCTTATCTGGTGATGGACTATGCTTCTGGTGGCACGTTGCGAAAACTGCATCCTAAAGGTACACGTATTCCCTTGGCTCCTGTTGTCTCCTACGTCAAACAAGTTGCAGATGCTCTCCAATGTGCTCATGATGAAAAACTCATTCATCGCGATGTCAAACCAGAGAATATGCTGCTGGGAAGGCGAAATGAGGTGCTCCTCAGTGACTTTGGGATCGCCTTGGTGGCCCAAAGTTCGCGTTATCAAAGCACGCCAAGATATGGCAGGGACGATCGCGTATATGGCTCCCGAACAAATTCAGGGCAAGCCGCGTCCTGCCAGTGATCAGTACGCTCTTGCAGTAGTCGCCTACGAGTGGTTGAGTGGGGATCGACCTTTTCATGGATCATTTACTGAGATTGCTGTTCAGCATGCAGTTGCAACTCCTCAGCCCCTAAGAGAGCGAGTTCCTGTTTCTCCAGCAATTGAGCAAGTAATCATGATAGGGCTTGCGAAAGAGCCAAAGGAGCGTTTTAGCAGCGTACAAGCTTTCGCTAGCGCACTCGAGCAGGCTTTTCAAAAAGAGCAAGCAACAACCGTCTCCCTGCAGTTTCCTTCAGCACATGTATTATCTCCTCCCTCTCTCCCATTAACAGTTGCACCATCAATTGCCACAACGCACCCTGGGACATCTCCCGCTTCTGTAGGAAAACACCTTTTCTCCTATCGCAATCATATTGCTCCGGTGTCAAGCATTGCCTGGTCGCCTGATAGCGCACGTATTGTCTCTGGGAGCAGTGATAGGACTGTCCAAATTTGGGAAGCACAAACAGGAAGAACTGAAACGGTATGGAATTTCCACTCATCCCCTGTACGGACTGTTGCCTGGACAAAGAATGGTACATATATTGCTTCTGCGGGTGAAGACACAACAGTTTCGATATGGGAGACTCTGACGAGAAGAAGTGTGATGACTTATCAAGAGCATAAAAAGTGTGTGAGTGCTCTTGCCTGGGCCCCTGATAGCGATCATATCGCTTCTGGCGGTTTTGATAAAACAATTCACCTTTGGAGTGCAGTAACGGGCAGGAAAGTCCTGACCTATCAGGGCCATACGAGGAACATGGGAGCTTGGGTCAAAGCGGTGGCATGGTCTCCCAATGGAAGGTGTATAGCTTCTGGAGATTACAATGGGGAAGTCTTCGTGTGGGACACAGTAACTGGGGAATACCGTTTACACTTATCAGCCTCTAGGAGTGTCAATGGTTTGGCATGGTCTCCTGACAGTGATCGTATTGCCATTGCATGCAGTTCTGGTAGACTCCTCCTTGTACAGAGTTTGGCTCAAGAGAGCACTTCCAGACATCATATGAATCAAAATGAGGACATCGGCCTGACATCAGTCGTCTGGTCACCCGATGGCAAGTTTATCGCGCTTGGAGACGAGCGTCATCAAGTTCACATCTGGGACCCAGTAAGTGAAAAACTTCTCTATACCTATCAAGGACATGCCAACCGTGTACTAGCAGTAGCTTGGTCTCCCGATGGGCACCAAATTGCCTCTGCAAGTGCTGATAAAACTGTGCAGGTTTGGCAGGCACCATAGGAAGAATTCCTAAAATTACAGAAGTTATTATCTAGAATTAAATGAATGAGGGATAAATTCACTGTTTTACAGCCTAAATGGCCCAACATTTCGTGCTTTGTCGTCGTATCCTGTATTCCCTCATCAAAAACCCTGAAGGGTCGATGGAGAGAAGAGTCTTAACTCATGCTAACAGGTGAGGAATTTCGCACTTGGTGCCAGCGTAACAAGATCTCGTCAGAGACGGAAGCCGTCATTGCCCGTATTCGTTCCTCCCCTCCAGCTCGTCGCGTGCGTGGGCGAGCTTCGAATATGAGTGGGCGGTATCCATCTGTGAAAATGGGCTACTCCATCCAGTTTGAAAGTCAGGTGGAGTTTTTGGCGATCTACGCGATGGAGCGCGATGATGATGTCCTGGAGTATTACGACCAGCCAACACGCATCCAGCTTCACTACCGCTCTTTGAGCGGTCACAAGACCTCACCGTGGCATACCCCTGATTTCCTGGTGATCCGCCGCAATGGGGCAGGCTTTGAGGAGTGGAAGCCGGAGAATGCGCTCGAAGGGTTAACGACCCGCATGCCTGAGCGGTATCAACCCGATCCACGAGGTGGATGGCGCTGCCCTCCTGGCGAGCAGACGGCAGGCGATCTGGGACTCGCGTATCGGGTACGTACCTCTGGCGAATACCACCAACAGTACATCGACAATTTGAAGTTTCTCCAAAATTTCTGGACCCATCCCTTTTCCGTTCCTCAAGCTGCAGAGCAACAGATTCGAGACGCTCTCGCCGTGTACCCAGGCATCATTGTGGACGCACTACTCCAGGCGCACCACGATCTCGTGGTTGATGTCGTCTGGGCCATGCTTACCACTCAGTCCATTTTTACCGATTTGACCGCGGCCTCGCTTATGGACTGGGAGCGTGTCTTTTTGTACGCATCAGCCTTGGAGGTTGAGGCTGTACGACAGGGAGCCAATGATGTCTCCCCTGATCCACTCATTGCCTCGCCGCTGATCATTGATGGGCGGCTGTGGGAAGTCGAAATGCAGGACACACAGGTGCTGCTGCGTCCAGAAGTGGGAATGCCCTTCTCCCTCCCAGTCGAGCAGTTTCACTACATGATAGCCTCGGACCTGATTGCGCCTGCTTCATTCTCCACCCCTTTGCCGCTCTCCGAAGTCGCACGTGCGCGCATCGCCAAAGCTTCCCTCAAGGGCCAGGAAGCTGCCAACAAACGCTGGCGCGAAATTCTTGCGTATGCTCGCGGGGATGTGCTCACCGTCACGACACGCTCCGTGCAGAACTGGATAGCTGCTTTCCGCCAAGCGGAAGCCGACTTCGGCTGTGGATACATCGGATTGCTCGACCGTGTTGCTGAGCGCGGGAATCGTGCTCCTCGTGTGCCCGATGCCTCCAAGGAATAGCTCAATGTGTATCTCACCACGCACTACGCCGCTCCTGTCTGCAAACGGGCGATAGCCGTGTACCGCCTCTACCGAGAGGAAGCCTTAAAGCAAGGCATCTCGCCCGTCGGCGAGCGCACCTTTTATCGAGAACGTGCCGCCTTTAAGGACGCCCAAGTTGTGGTCTCACGCCGAGGAAAACGCGCCGCCTATGCCCTCGAACCGGCCCTGGCTTATCTGGATCAAATGACCCCTCGGCATGGTCAGCGTCCCTTTGAGCGAGTCCATCTCGATCATACACAATTAGACATCATGCTCGTCTCCTCGGTCACAGGAAAACCTTTCGCAAAACCGTGGGCCACCTTCATGACTGATGCCTACAGCCGCCGGATTCTTGCCTGCTACGTGACCTATGATCCACCAAGCTATCGCTCGGTGATGATGGCGTTTCGGCACTGTGTGAAACACTATGGACGCCTCCCCCAGGAGTTGGTAGTGGATCGCGGCCCCGAATTTCAGAGTGTGTATTTCGAGACCTTGCTCTCGCGCTGCTTTGTAACCAAGTTGGAGCGGCCTCCTGGGCAACCGCGCTTTGGGTCAGTGATTGAGCGCCTGTTTGGCACCACCACGACCGAGTTGCTCAATCAGCTTCGAGGCAATACTCAGGCCAGCAAGATTCCCCGACAGGTAACGAAGGCCGTTGATCCCAAGCGCCTGGCCGTCTGGACCCTGGACGCTTTTGCACGTCGCCTGGCTGAGTACTGTCTGGAAGTCTATGACCAGATGGAGCATCGTGCCCTCTTTCAAAGCCCACGAGAAGCCTTCGCGCAAGGGATGCTGCGTGCGGGCAGCCGGACACGGTGATTCCTTACTCAGAAGATTTCCTGATCCAAACCAGGCCCTCGACCCGCACAGGGGTCGTAAAAATTCACCAGGGCCGAGGGATCACCGTGAACGGCTTACAGTACTGGCATGAGTGCATGCGCTCTCCTTCCGTCGCCGGAAAAACCGTTCCGGTTCGCTATGAGCCTTCCAATATGGGATTTGCCTATGCCTACATTGATGGACAGTGGGTCGAGTGTATTGCAGACGCTTTCCTCCAGGTGCATGGACGCTCTGAACACGAATGAAATCTCATTCTGGAGGAATGGCGTGAACACCAGCACCAGCATCACGAGAAACGCGTGACCCTCAACGGGAAGCTCCTGGTCGAGTTCTTGCACAAACTAGAAAAGGATGAGGCGTGGCAGCTCCAGCACCTGCGGGATCTGGAAGAACAGCCACAACGCGAAGCCTTGCTCCTGCTCGGCAATCGCCCGGTGGAGGTGATTGCCGAGACAGAGACAGCCCCAATCGAAGTAGATTTGTCCTCTCTTCCAACCTATGAGGTGTATCTCTGATGCAGACCATTGATCTCGCCAACGTCGAACTACTCGAAGACTTCAGAACCTTGAGGGTTGGTTTTAATTGTATTGCATATAGAGTCTAAAAATGGGAAAAGATAGTTTTCTAGATAGTGAACCTCAGAACACAGCAGATAACTCTTTTCTCTTTTCTACTGTATTCCGAAATTTCTACAGAAAACTCTGCTTCTCCACGACAAAGGGCCTTGGTGTTCACGGGCTGCCATGATGATGAGATTTCTCGTCTGGCGAGCGCCTCCGCATTGAAGAGCGCACCCTTTCCATACAGGCTGTTACCCTTTACCGGCGAATAGGCGCATCTTCTGTCGGTCCATGCACACCGAGGGCTGGAAGAAGTATCCGATCAACGATGGCGACGATTTCGGTATCATCAGGTGATGACCCCTGCAAGAGCTGTTGCATAATCATCATAGCTCGACCTGCCTGGCAGACTTGAGGCGTAATCACTTCCCGGCGAATCTCGCCACGTTCGGTGCTGCGCTCAAGGACCTGAAGGATCTGAGAGTGTGGTTCAAAAATCTTCGTGCGAATTGCTGCGATTAAATCTGGGTGATGGAGTCTATCCCCAATGATGGCTCTCATCGTCGTGCCGACCGGGCTATTCATAAGCTCTCTGATGTTCTTGTGTACTTCAATGAGATCCTCCCGAAGATTCCCGGTATCTGGCGTGTGCGTTGTGTTCTCCTCAAGAGCATTAGTCAGGGCATCAAGGACTAATTCTTGCACAGAGGCCCAGCGCCGATACAACGGCATTTTGCCGGTGCGCGCTCGGAGTGCGATTCTATCCATCGTGAGATGACCAAAACCGGCATCGGCCAGTTCTCCCAACACGGCAGCGTAGATCGCCTGTATAAGAGCATCTCCTCGTCGCCGCCTTGAAGATGGTTGCTCATGCTTTGCTCTCTTCATCTTCTTGTTTCTCTCCTCAATTTCCTACCCAAATTAAGATACTATTGTGTATCTTCCTTATCTAGTATATACTACGCCTAGATAAGATACTATTTTGTATCTTATAGAGTGCCGGAGAAGTTCTGGCCTGACTTCCCTTCGTCTGGCCGACTGCAAAAGGCCAGGTGAGGTCATACGTTTTTGTGTTCAGGAGGTATCAATCTATGGGTCTTTTCACTGAGGCTGAAATTGCCTATTTGCAGAAGCAGCGCCTGGGGCGTCTGGCTACAGTTACGAAGACTGGCAATCCTCATGTTGTTCCAGTCAGCTTTCTTTATAATCCAGAATTTGAGAGCATTGACATCGTTGGGAGAACACTTCCCACATCTTTAAAATATAAAAACATCGTCATTAATGGACGAGTGGCCTTTGTTGTTGACGATATTGCTTCTCTTTCTCCTTATCTGGCACGCATGATCGAGATTCGTGGGTACGCTGAAATTGTGCTCCGCGATGAAAATGATCCTCTTCCACATGCTTTAGAAATGTCACTTGAAATGAGACGTACTATAGCCAGGAATGTCGCGCCCGAAATGATACGTATTAGAGCGAAAAGGATCATCTCTGCTGGCCTGGGAAGCAATCCACTGAGCATGAGCCGTCGCACCATTGCGGACGATGGCTCGGTGACAGAAGCTCGCACACCTCTTCAGCCTATTCAGTTCGACGCGGAAAAATAGGATACGATCAGTAGATCAACATAGTCGCATCAAATACAGGAGAAACTATGCTAGATCCGAAAGATTGGAACCGCCGCCTGATTGAGGAGTTTCGTGCAAACGGAGGCAAGGTTGGTGGACCATTAGAACACATGTCGTTGCTCTTGCTTACAACTACTGGTGCCAGGAGCGGGAAGCCTCGCACGACGCCAATGGGGTATTTCTCCGATGGCGACTGCCTGATAGTGGTTGCCTCTAATCGTGGTGCATCAACGCATCCTGCCTGGTATCATAACCTACTGGCACACCCGGAAGTCACCGTCGAGGTTGGGACTGAGACCTTCGAGGCCATTGCTATTGTCACAAAAGATGCAGAGCGAGATCGGCTGTGGGCTAGAGCTGTAACGTTGTTCCTCACCTTCGCCGAGCACCAGGCAAAGACAACGCGCCTGATCCCCGTGATCACGCTCTCCCGACGAGCAAGCTAAAGACCATCTATGCCTCATTATGCTTGAGGCACACCGATTGTTTATTCAATCTTCCAGAAAGGAAGGTTTCTGATGACCACTGTATGGATCATCGTATGGATAGCCCGTCTAGCAGGCATAGTCGCGCTTGTGCTGGGCCTGTTCTTCTGGATCACCAGCATAGATGTGGTCAATGTTCATATGATCTTTGGCCTGATGCTTGCCCTTTCGCTTCTCATACTTGGGATCATCATGCTTTGCTCCAGAGGTGCCCGGCTTCTGGGAGTTGCTGGCATCGGATATGCCTTTTTACTTCCGATCTTTGGCTTAGCACAGGCCAGTTTACTCATGGAGCACATGCACTGGCTAATTCAGATCGCTCATCTGTTCGTTGGGATTGGCGCAGGCGCGTTGGTTCAGGGAATCTCTGTGCGTTACAGGCGTCTCAAGCTAACCACCACTTCAGAAACTCCGTCGTCTCAAGCAATACGGCAAGCATGGAGAAAAAAACATGTTTAAAACATTGCTAGCAATTCTGGGAGTAAGTTGTCTCATTACCGGGTTGCTAATCGCCTGTGGCAACGGCTCCAATGCGAGCATAGGTCCCAATCCCATCCATATGAACGCCACGAATTTTCTTCAGACCTCGATTACAGTGAAAAAAGGCGAGCGCATTACACTCATCGATGATGATCTCTCAGTGCCACACATTATCGCCAACGGAACGTGGGAGAATGGCACGGTGAAACCAGCCAGAGAAGCAGGCGCTCCAGAGATCAACAACGTGCAAATCAATGGAAACAGCTCAGAAACCATTGGCCCTTTCCCCTCTGCTGGCACATTCAAGCTCTATTGTACCATTCACTCTGGTATGAACCTGACTGTTGTTGTGCAATGAGGGCGTGATCTCTCATGACCAATTTGACCGTCTTCGTAAGAAAAGAGACCAGTCACATGAAGAGGATTCCGAGACGAAAGAGCCTCTCGGGATTCTCTTCATGCGGGGATGAATGCTTCCCTCTTTGAGGCATGAGCATGTGCAAGCGTTTGAAGAAAGAAGGTCGCATCTCATGCGACCTGCCTCTCCCTGTTTTGACCAACAGATGCTCGCGCAGATGCAAGACAATGATCCAGTGGTTCTCCGCTATCGAACCTTGTTTGCGCTGCTAGATTGGGGTCTGGTCCCCGAGCGCCAAGCGCTCCCTTCTCACCCAGGGAGACGCCCACATCCAGAAATAGCCTACGTCAAAGCGTTGCTCATCAAATTCGACTCCTGTACCCAACTCCGACGCTTCCTGCTGGAACATCCGCTTTTGGTCTTGGAACTGGGCTTTCGTCCCAAGCCCTCTCCTCACAGTCCCTATGGCTTTGATATCGAGCGCACGGTGCCTTGTGACCGCTGGTTGCGCTATAAACAGCAGACATTGAATGCAAGCGTTCTTCATGCTTTGTTTGTTCATACTGCTCATGCGCTAAAAGCAGCCATTCCCGGCTTAGGCGAGAAAGTAGCCATCGATGTGAAGCACTTGTACGCCTGGGTGCAAGAGAATAACCCCAGCCCTTATGTCAAAGAACGTTATAATCCCCAACGCCAGCCCAAAGGTGATCCCGACTGCCGGCTGGGCGTCAAACGTAGCAGCAATCAAGAGCAGCCCAATGGCTCCACCAAAGTTGTTAAAGAGTACCTCTGGGGATATGGCAGTGGTCTGATCAGTGCCATATCCCAGAATATGGCGATCTCATCTTAGCTGAATATACTCAACCTTTCAACAAGAATGATATCACATATTACCATTCGCTCTACCAACAGATAGTTGCTACACTAGGCTTCCGTCCTCGCCAAGTCACCGCTGATGCTGCCTTTGATGCTTGGGATGTCTACCAAACCTGTGCCGAACATGGTGGCATCGCGGCTATTCCAATCAATGCTCATGGCCACCCTCTGCCCAATCGTGAAACTGATGGCACCCCCCGTTGTGACAGAGGGCTGCGCATGTTCGCCTCCTACCAATTTGATCATACCAATGGCTATCGCGCCCAACGCTTCTGTTGTCCTCTCTTGTATCCTGTTCCGATGGGGCAAACCTGTGAGCATAAGCAATTTCTCAAGGAGAAAGGTTGTGTCAAAGACATCAATATCGAGCTCGGCGGTCTCCAAAGAGTGCTGCTGGATCGCACCTCCCAGACCTACAAAACAATCTATCGACAACGCACCTCTGCTGAACGCATCAACAGTCAAGCTAAGTCCTGGGATATTGAGCGCCCCAAGGTTTGTAATGGGCACTCCGTTGCTAATCTCAATACACTCACCTACATCCTCATCAATGTTAGAGTTTTACAACGTGTATATGCTGTTAATCTCGTATATCGTCGTTGTTGATTTACAACCGACCCACCATATGAGGAGACGCAAACGCAAAGACAGCGATGGGACAACTTCTCGCGCTAGGGCAGTGGAAGATGAGAAGGTGCAATCCTCTTCTGCACAAGAGCTCTACTAAGCTTCGTTGATGTGGCAGGGGAAGTATCCCTCCTTGCTCCTTCAAATCCAGGGCAGGAGTGAGGAGGAGTCCAAACACCCCGCACAAGAGCGTTGGGCCGTGGAAAATTCCACAGCCAGTGGCAGAGTTTTCCACATCGTGTCCGTATGCGCATTTTCCTCCTGTCTGCCTCCCGCGTTCCTTCCCGTAGCAGGCTCATCGTCTCGCGACCACCACGATTGCGCGCAGCCTGCAAGATCAGCCCACTGAACTGCTTGAGATGGACAACGGTGCCGGAGGAAGAGAGGAGGAGCTGCCGCAGGTGCTCCTGGGACAGAGCCTGTGCTAAGGTGGGAGAGCAGCACAGCAACAGATCGCCCTCCTCTAGCTCCTGCTGCCAGATCTCCTCCTCGGCGCCCACTGAGCAGAATAGAGGCAGCAACGTTGCCTGCTGCTGCCGATTCTAGAGCCAGGAGTGCGCCCAATGCCCAGAGAAAGCCAGGAGGTACTGGAGGCAGCGAGAAACGCCAGGGACCTCGCCAGCCAGCCGCCGGCAGCAGACGTGCTGGGGAGAGCGCCACAAACAGACCTACGCACGCCAGCAGGCTTTGCCAGAGCAGTAGGACGCTCAAGGCAGCGAGCACACTCCAGAAGCGTGCTGACATCCAGGCCGGCAGGCGCGCCTGGGGCAGGCCGCTCAAGAGGATACCCAGCAGCAGCAGACTGCTCACCGGCAGGTGCCAGCTCTGCCACGCCGCAAAGCCAGTGCCAAACGACCTTTGGAGCTCAATCAAGCTCATTGGTGTATCGAGAATCGCCTCCATTATCGTCGGGATGTGACCATGAAGGAGGATGCCAGTCAAGCTTCGCATCAAAGGAGCTCCTCAAGTGCTTGCCGCCTTACACAGCGCTATCCTGGCTTTGATGGATTGGTTAGGTGTTTGCAATATGGCTTCGCAGATGAGGCATTTTGATGCCCATCCTCACGAAGCCCTCCAATTGCTGCTTGGAAGGCTTTCGCGGTAATTCCGGTACACTAAAAAGCCCTGTTCAAAGGTGTAGCAGGCTTGACAACAGGCATAGCTCCATTCATACTGGTAATGAGTGTGGGAAGAGGAAGCCGTGTCTCCTCCTCACGAGAGCATATATGAGTGGGCAAAGGATGGTCTTTGCCCGAAAGAAAGGCTGTATGCTGATGACCACTCCTCCTGGAGAGAACCGCCTGGTCACAGACCCAGAACTTTTGACAGAATTGGTTCGGCTCGATGGCCAGGGCGAAATGCTCACCCGGAGTATGGGAGGAGTCCTTCCCGAACTAAGCCGAGCTGAGCGCAACGGGATTCAGGATGTGCTTGACCTTGCCTGTGGTCCGGGGGAGTGGGTGCTCCAGCTTGTCTTTGAAAACCCGAAGATGCATGTGGTCGGAGTGGACATCAGTCACAGAATAATCAATTATGCCAACGCGAAGGCTCAAGAGGAACAAAGTCCAGCAACCTTCCAGATCCTGGATGTCTTGTCTCATCCGCTGCCATTTGCTGATGGCTCCTTCGACCTGGTGAATATGCGCCTGGGGTTTTCTTTTTTGCTGCCTGGGCAGTGGCCTTCCCTCCTGGCTGAATGTCTTCGCCTTCTCCGGCCTGGTGGTCTCATTCGTCTCTGTGAGACGGAACGAAGCCTCTCTAATAATGCGGTGTTCGAGAAGTACATGACCCTCTGGACAGACACCTTTTTCCGCGATCATCGCACCTTTTCCCCAGATGGTCTTCATTACGGCTTACTTCCCATGGTCAAGCTCCTTCTGGAACAAGCAGGGTTTATGCAGCTTCGGCATGTTCCCTATATGATCGACGTATCAGCAAATAGTCCGACGCACCAGACCTTCTTTGCAGATATGCTGGCCCTGCTGCAAGATGGCCTCCCGTTTTTACGGCGAATGGCACGTGGCCCCTCTGAACTGGAAGAGCTTGAGGCGATCTATGATCAGCTTCGTGGACTCGTCAATCAGGAGGATTTTTGTGCCTACTGGCCGCTGATGACGTTTCTCGGTTCCAAACCCAAGATGCCGTAAGAGCACCTCACCAAAAGCTGGTAGGCAGGAGACGCGTTTGGGCAATTCGTCGGAGGACCACCGTCGCCAGACTATGAAGCTGTTCTTGCCGTTCAAGTGGGTCGTTTTTTCATCTGGAAGCTCATCGAGCAAGGAAGCAAGTTTCGGTTCCCAGCACGCCAACGTCTCCGGCGTTATCTGTCAGCGAATGGCTCCCGCGTCCATCCGTGAGCGATGCGTTCCAGCAAAGCGAATGGCCCTGCGATCCTGGCCGACCAGGAGCCACGAGGCCTCCCATGAGGCGCCTGCCCAAGGAGTCCAGAGCACTGTTTCAGGAGGAAGATCTGTGGGGAGAGGGATGGGGCATGGAATCCACTTATCATCAGGGCCAGATTGCCGCCAGCACCACCAGTCAGGTTCCTCGGGAGCCATTGAAGTGGGCAGAAAGCCCTTGCGTTGATCCTGTACCAAAAGCCTGTAAATAAAAACAGCAGCGGCGTTTGACGGATCAGGAATACCATGTTCTCGAAAGCGCAAGAGCCCTTTCCCTCGCCAGTACTCGATGCTCTCATTTGGAGAGCAAAGCCCAGGCGCGTATGGGCATGACGTCGAGGGGCGAGAAGAGTACGATCACGGTCATCAAGATGGAAGTAGAGGGCCAGTTGTTCAGGAGACGGCTCTCCGATAGAACAGCCATAGCGGCTTCGTTGTTCAATCGTGAGAAACGCAACGGGCATCGGACAAGCATCCTCTTTCGTATGAGCGTGCCACTCCTCATAGGGTAGAGAAGCGTGGATGGAGCTACCATAGCAGGAGAGGCCACCTCACGACAAGCCATCGACACACAAATAGGACCAATGTCAGATACTGTTTTCGTCGTCCAACAAACGTCACCAGTGGGCCGAAGTTGAGCATGGCGTTGTCTAGGAGAAAACGGACGTTATCCCACATACAGACTGGACTGTGTTCTACTTGCTCTCACCCATACAGATTGTCTCCGTCTTGTGGGAGAAAACAGGTTAAGAGGATACACCCCAAAAAATGAGCAAGACCATTGCCTATTTGAGAACCGCCGCCGACAAACAGGATCTCAACAACCAGAAGTTAGAGATCCTGGAATGGGCCAGGAAAAAAGACCTGAAGATTGACGAGTTTGTCGAAATCACGATGTCTTCTCGTAAGACCAGCAAACAACGACGGATCGAGGAAGTCCTGCGCATGCTGACCGACATGGATACCCTGGTCGTCACCGAGCTTTCATGCCTAGGCCGCAGTACGGCTGAAGTCATCGCCCTGATCAATGAACTGGTTGCTTGCAACATCCGCGTGATCATTCTCAAGCAGAATCTGGATATCTCCCAGCATGATATGCATTCGAAAGTGATGATAACCCTCTTTTCGTTTTTTTGCAGAGTTGGAGCGCGACCTGATTAGCCTGCGGACCAAGGAGGCGCTCGCGGCGAAAAACAACAGGGAGTCAGGTTGGGCAAGCCGAAAGGCACGCTCCAGAAAAGCAAGTTTGACGCCGATCAAGAGAGGATCAAGGAACTTCTGAAACTGGGACTCTCAGTGCACAAAATCGCTGCCCTCCTGGGGTAGAAAAACCATCTCGCGCTCAATACCTACATCACCAAACGCCAACTCCGCGAACAAAGCTCATAGGTGCCTTAGCGGGAAAAATGGCACGAAAAAATGTTATCACCCCTAAAAGCGCAGCAATCGAAAGAGGTATCGTCATTGAGTGCAAACACACCCTCGTGTCGCGCCTATTCATGATGCTAGCTCACGCAACAGCATCAGTATCAAACTTTCGCCAGTCCTCGTTCGCAAATTTACACTGTGGTATCATCGCTTGTATCGTTTCTTCATTTTGATGAGCAACATGGCTTGAAAAGAGAAGACCTTCTGACTCCTTTTTACCACTAGAGAGAGATACATCTGTTAGAAAGGCTACCTACTATACGATGGAAGAGAGATCAGATGCTGAGCTGGTCAGATTGGCCCGCGCTGGCAGTAAATACGCGTTTCATCAGTTGATCGAACGCTATCAACTGATGGCAATGGGTCTCGCTTTGCGCCTGTGTCGTGAAGAGGAGACCGCGCGTGATCTGGTACAAGAGGCAATTCTCCAGGCGTTCCTCTCGCTTGACCATTTGCAGGACCCCACTCGCTTCAAAAATTGGTTGTATGGAATTGTCTTCAACGTCTGTCGCAATTGGAGACGCACCGTAGCGCAGAGGCCATCTCTTTCTCTGGAAGCACAGGAGGAAGAGACCCTTCATCAAAGGCTGTTCTCCTACAGATCTGGCGAGTTGTCTGTAGACCCGCTGACCATGATCGAGACAGATGAACTGCGACGGCTGGTACAAGAAGTGCTCCAACTTCTCTCGCCGAAAAATCGCCTGGTCGCGCAGCTCTTCTACTACGAAGAGTTGAGTGTGCAGGCGATAGCGAGCCACTTGAACATCTCCCAGACAGCCGTGAAGAATCGCCTGCACAAAGGACGAGAACAGCTACGTACACACCTGCTACCTCTCTATCCCGAACTCGCCTATAGAGGAACAAACAGATCAGTGGAGGAAAAGATGATCCCAGTCACAGTAGCCAGAGTGGTGCAGCAGGACACGCAGGCCCGCAGCGCTGTCATTTTGGTAGATAGGCACAAGCAGCGTGCCATGCCGCTCTGGTTTCCCCAGCAGGAGAACATGACCCTGCGGCAACACATGCAAATGTTCTCAATGTTCTCGCAGCAGGATCGTGTTGCCGAACCCACAACACTCGATTTGATGGTTGCCATGCTGACTTCGCTGGGTAGCGAGATCAAGAAGGTGGAGATCGATGCATTCCAGGGCCATATACTCTATGCTCAGCTCTCCCTACGCAGTTCGCGCGGAAAGCAGACGCTCAAGGCTCATCTCAACGATGCGCTGCCGTTGGCCGTGCAACTGCACTGCCCATTTTTCGTCAGCGGAGAGGTCTGGCGGCAAAGAGGAATCGATCTCCAAGGAAAAGGAGCGACCCTTGCAGAGCAGCTTGATACCCTGATAGCACTGGTGAGCACGACATTCTCACCCCTGACGACGAAAAGCTCTGGCAAGTTGGATTTTGTAGATGGGCTAGCCGACTGGACAATCCGCCTGGACCGCAAACAGTGCGACTATCGTCTGGATAGCCAAACGACCTACACAGGAAAGCCTGCCTTACTCATCACCTTACAGGACTGTCGGGGAATGGTGCAATTGTGCCATGAAGAAGATGCTGGCCGAGCCGTACCATGGGCGCCGCATTCGCCTGGTGGCCTACATAAAAACAGAAGATGTGCAGCGCGCCAGCCTCCATCTCTCCGTGACCATGCCTTCGCGAAATCCTCAGGAGCTATTTCCCGATTTCCTTTCGGTAGAAAATGAACCGCCCATTGAGCCTACACAGGACTGGCGGCGGTATGAACTGGAGATCGATGTGCCTGAGGATGCCTCTAGCTTGCATCCTGTGTTCAATGTGTGGAACACAGGAAAAGTATGGCTGGATGGCTTTCGCATCGAAGTAGTAGATACTCAGGCGTATAAAAAAGAGGAGGAACACAGATGATTTCCGCCAACGTAGCGAATGTACAAAGTGCTGAGCGCATGGGGATGATTATTGTTTACGATAACTAACATGCGGCTCATCCTCACATTAAATGAGCTTGGTTGATTGTGAGAAAAGAACTCTCTTGAGGGAGTACAACGAGGGAGGGTGTGTAGAAACGGAACGCCGAGGGCTAAACCCGGCAGAGGACGCGCAGCCGCAGGAGATCGAAGTTTGCTCGTCCGAAGACGATCCGCTTCTGAAGTTTGAGGCAATTGACCTGCGCCTCGACCTGACCATTACTCCAGATGCTCGAAAATGCGGCACGGACGGCTGCATAATCGAGACGAATTCCCCTCGCCATCTTGCGGAATTCGGGAAGGATGCTTTGTTCAGCGGTCTGAAGCCATGCATCCAGATCCCTGTCTCGATGCTCGGCCAGCATCATGACAAATTGTTGCCCTAATTGGTAGGCTGTTTCCAGATCGGGATGACCTTCTCGGATTTGCTCAACGTACTTGCGTTGCTGTTCATCCAGTTTTTCTGATCGACTGACAAGAAGCCAGGAAGCCCGCGTGGGAGACATTCGACGTTTCACCAGGGGTTGGGGAGGAGGCGAAGCCGAAGTTTCGATGGGAGGGGTTAAAGCCTGATGTACTACTTCCACTGCTCTCGCTGCCTTGTATTGCTTGCGAACACTGGCAAGAAAATTTCTGAGCAGAGATGTTGACCCGGTATAGCCACGAGCTTTGATCTCATCGTAAAGCTGAACACTGTTTCTACAGCCCTGTTCCCAACGCTCCCGGATGTAGGGCTTGTACTGATCCAGCATGCTGCCCCGTGGTCCTCTTCGGTGTGAGGCCATTTCAGGATACTCTTCAGCTTTGAGAAAACGACGAACGACCTCGCGGCACACCTTCAACTGTCGAGCGATGGCACGAACGCCAATCCCAAGCGTGTTCAGCCTTCGTACTTCTTCATACAAGCCATAGCGCCTCTCCCGTCGTGCCTGCCGGTGTAATTGTCGAGAATTGTCTGGCGGGGGTCGCCAATAGGGGGTCGGCGGGATCGTTCGATAGTGTTTTTCATCTGCCACCTCGACAGATGGGGGAACTGACTCCTTGGTGGGTGATCCTTTGATCCCTCGTGCGCGAGCAGGGATCGCATCAGCCCTGGTTGAAGCCTCGTGGGGTAAACAGGAGTGTCTCCGGTCCATTACCTCCTTGATCCTCTCTCGAAGGTTTTTCAGCAAATGGAATTTGTCGGCCACCTGCTCGGCTTGTGGAGCACCACGTTTGGCTGCTGCCGCATAATCTCCCCCTCGATCACGGCTGACCAATGTAATCTCTGGATGCGATCTCAGCCAGGTTTCCGCTGTTTGGGCGCTGCGATCTTCTAAGAGTTCAATCGGGCGACGACTTTGGAGGTCTACGACCAGCGTGCCATAGGTCATACCTTTCTTCCACGCCCAATCGTCGATCCCAACAATGGGCACAGACGTAGGTGGGGTGTAGATGCGTGCTCGCATCCTGCGCAACAATGTTGGTCCAGAAACCTGCATCCCCAGTTTGGGTGCAAGACGCTCTCCCAGTTCTCCGCAGGTGGCAAATCCAAGTGTCTGGAGGGTCTCTGAAAGCCGATTGGTCATGCGAGCATAGGAATGCACCAGAGAATCGAGGCGCTCCGTAAATATGCTGTGTGAGCAAGTGGATGTGGGACAGACAAAGCGGCGCACTCTCAGCTTCAAAATGACGCGCCGACCCCCAGCTGGCAGATCCGCCACGGTCCTGACATAGGCTCCGTGTATCCGATCAGATGAACAGCTACAGCCTGGACAGAGCGCGCATGGGTGATGGCAAGCAATGTGAACCAAGACACTGGTTGCGTCTTCCTCAACAGAGGTGATGCTCACCCCTTCTGGCAGAGGTAAAAAGGGCGAAGTGGGGTCTGTCTGGCTCATCGATGATGTTCTCCTTGCAACGTAACAACACACAACCATCGATGAGAGTCTATCAGAAAACTTTACAGCGGTTCAAGTAACCAAGCTCATTTAATGTGAGGATGAGCCTAACATGCCTACCACCTATCCTCCAAAAGTTACCTTAACCAACCAATCAGGCTGCAATAAAAAGTTAATGACAATTTGGTAATAAAGTGTAAAAAAGGCGAAATTGTTAAAGAAAAACCTTGCCATCATTCCCTCTTCTCAGGTACGATGAGATCGAGAATAGCAAATGGCTTAGTCGAGAGGAGAGAGCGATATGCTTACCCCTGACGAGCGTGAACGGATACGGCGTGCCTACCATTTTGATCATAAAAGCATCAGACAGATAGCGCATGAAGAACAACGCAGCCGTGAGGCTATCAAACAAGCACTGGAGGATGCGCCTTCTGCCCCCATCCTGTTTCTCGTTCTCGCTTGGCTCCTGTCTTTGGACCCTACAAAGCGCGGGTAGACGCACTTTTGAAACAAAATGAACAGCTTCCTCGCAAACAGCAATACACTTCCCCCAAAATTTTTGAGATCATCCGAACCGAGGGATATCAAGGATGTGAGTCTCGCATCCGACAACATGTGGCGGAGTGGAATCGAACGCGCAAGCAAGAAGTTTTTCTTCCTTTGGAGTTTGAACCCGGCCAAGATGCCCAATGCGATTGGGGAGAAGCATACGTCGTCCTGGGTGGAGAGCGCAAGAAGGTCCAGATCTTTACCATGCGGCTCTGTTACTCGCGTCGCACCTTTGTTACCGCCTTTCCTACCCAGAAGCAGGAAAGTTTTCTGTATGGTCATGTTCTGGCATTCAACCACTTTGGAGGCATTCCTTATCGCATCAGTTATGACAACCTGGCAACAGCGGTGAAAATGGCTTTTGATCGCCCAAAACAACGAGGCCGACCGCCTCGTCAGGAGCAAAGAGCGTTTCAGTCTTTTCGCAGCCACTACTTGTTTGAGTCGCATTTTTGTACCGTTGGTTTGCAAGGTGCTCATGAGAAAGGCCAGGTCGAGCATGGCGTTGGTTTCGTTCGCCGCAACTACCTCGTTCCTCTTCCAGAGGTCGCATCTTTTGAGGAACTCAATCAACTTCTCAAGGAGCGTTGTCTGGCTGATGATGAGCGACGCGTTTCCCGTCAACCTACGACCATTGGACAAGCCTGGCAAGAGGAGCGTTCTGCCCTGCGCCCGCTGCCCACATTCGATTACGATTGTTGCGAGATCACGACTGCACGCCTGACGCCTTACAGCCAAGCCACCTATGAAACGAATCGCTATTCTGTTCCGGTCAAACGGGCGAGGAGTGCTGTAACGGTCAAAGCCTATCCCTTTCACGTTGAGATTCTGGATGGGACGACTGTTCTGGCACGCCATCCTCGCTGTTACGGCAGGGAGCAAGACCTGTTTGATCCCTTTCATTACCTTCCCCTGCTTGAGCAACGACCAGGAGCATTTGACCATGCCAAACCACTCAAAAAATGGCGTCGAGACTGGCCGGAGTCTTACCATCTTCTGCTACGAAAGTTGCGCGAGAAATGGCCCGAAGGACGGGGAATACAAGAGTTTGTGCGTGTGCTCATGCTTCACCAAGACTATCCTTCGGAGGAAGTCGCTCAAGCAGTTGAACAAGCCCTGGATCTGGGATGTATCCATCTCGATGGTATTTTGCATTGCTTGCATCAGATCAGCACTTCCCCAACCTCTGCCCCGTTGGATCTCTCAGACCGACCAGATCTGGATGCTGTTGGCAACCAACCCATTGATTTGTCTCGCTATGAACAATTGTTGAAGCAATCTTGGTAGAGGAGGAACGCCCATGCAACATCAAGCCCTGCTGGAAAGCTATCTCAGACAACTTCGCCTGCCGACCTTTGCCCAGAATTACCAAACATACGCCCAGGATGCCGCCCGTACAGATCTGTCCTATGAGCGCTTTTTGTTGGCTCTTTGTGAGGCAGAAGTAGCAGCGCGTGAGGCTCATCGAATTGAACGGGCGGTAGCTGCTGCCAAGATTCCTGTCCTCAAGGATCTTACCTCTTACGACTTCGCCGCCGTTGAGAATATCTCGAAACAAAAGGTGCTGGAACTGGCTGCGGGAGGCTATATTGCAAAAGCCGAAACGATTATCTTGATCGGAAATCCGGGACTCGGCAAAACGCACATTGCGAGCGGCTTGGCGCTGGCAGCCTGTCGGCAAGGAAAGCATGTTCGTTTCTACAGCGTCGCCAATCTCATTAATGACTTGCAAGCGGCCCAAAAAGACCTGCGACTGTCCCGTTTCACCTCTCACTTTACCAAGCTGGATTTGTTGGTCCTTGATGAGTTAGGGTTTGTCCCTTTTGCCGGTGAAGGAGCAAAATTGCTCTTTCAGCTCTGTTCCGATTTGCATGAACGAGTCTCCATTATCCTGACCACGAATTTACGTTTTGCTGACTGGAACTCAATTTTTGGGGACGAACGCATGACAGCGGCTCTTCTCGACCGACTTACATTCAAATCGCACATTCTCGAATTTGTGGGAGAGTCCTATCGCTTTCGCAGCCGCATGCGGCAGGAAGAGGCTAAAGATTCCGCTTGAAACCGCTCGGATGGAGGAGCAAGGAACCTTTTGCTCCCCCATCCTCTCCTCATTTTTGTCCAGGCAGGCCGTCCTCTTGTTAACTTTTGGCAAGGTTTTTCGGGTAACTTTTCCTTGAGCCTCCCCGGCTTTGGCTGGTTTCTTCGATAACTGTTAGCCTGGTTTGTTGTTATCGTAAACAATTATTACAAGGATGCTCCTTGTAGACGAACAACGACAGCGCGCTATGCTGCTCACGGTGTGTCAGTTCGACCGCACTTCAGTGGAAGGCATCTCTCTTCATGCTTCGCTGGAAATGGATACAGCCACGACTGCTCTCATGCGACCACGCACACTTGATCTCTTGAGCAAACTCCTCCAGGCGTCAGGCGGCGAACTGGAAAGGATCTGTATTGATGTCCTGCAAGATGAGATGCTCTATGCGCAGGTGCATCTGCGTGACCAGTACAGCCAGCATACGATCGCGGCAGGCCTGGGTGATGCGCTCTCCCTGGCGCTACAGTTGCATACTCCTATCAACGTGAGCGATGCGGTCTCTGCAAGGAGATGGATCAACCTGATCGAATATGGTGCGACACTGCAACAGCAACTTGAGGCGATTGCGCCTCTGATGCAGACAAGCCCAGAAGCCCTGTTCCTCAAAAAAGAGCCATGGAATAGAGATTTCGCGCAAGGTCTGCAGGGCTGGCAGTTCCTAGGCAATCCTGAGTGCACCAGCTACCGTCTTGACACTCAGGCCACCCACACAGGTCCGGCCAGTTTGGCAATAGATCTCCGTGAATCGCCTGTCCATGCCATGGCCCCAATTGGGGCACTCGTACACCACGAAGGGTTTCTTGCGCACCCGTATCAAGGGCAGCGCCTGCGCCTGCTTACGCACATCAAAAGCGAGCACATTCAGCAGGTGATGATGCAGTTGCACGTGGCTGGACCTCCAGCCAAGCAACTGGACGAGTCTACAGGAGTATATCTTCCTACCAGTACCTATGAGACGCATACTATCTTCCATCCTGCCACAGACCTCTGTGATTGGACACGCCTGGAACTCGTCATCGAGGTCCCCCTCGATGCCTTCACTGCTTTTTTCAACTTCTCAATAGAAGGTTCGGGCAAGCTGTGGATAGATGCAGTGGGCTTCGAGTGCGTAGATACGGGCTTGCGCTGACGCCGCTCACCTCCTGGTCACGCAAAGGACAGAAATGAGAGAGGACATCTCTGCTGAATGAAACTTTTATCTAGCCCATTTTAAAAGAAAGGTGACCATTTTCCTCCTTGTCGCCCCGCCGCTCTGAGAAATCTGGCATCAGGAGATGACGAGCAGCAAAGGACAAAAAACATGATTCAGGCTTCTATCGCCATTGAACAATGCGCACAGGAACACCAACTGGGAGAATTACAAAACGTCTCTGCCGAGTTTTCCTCATTCTCAAAGTCTGTCCTGAGAACCATCGTTCTGGGCATGGCATCCGTCATGTGGATCTGAATGGGATCACTCCTCATGCAAACAATGCCTCTCTGGGGGACACCTCGCCGTATGGTGCTGGGTCTCCCGCCATTTTGATGATTCGGGGACGTGTTCGCCTCAGAAGCTTTTACTAGGAGCATTGCAGCACCCGCTTGCGTAACGTCTCGAAGCTCGCTTTGCCATACATTTGACGCTTTAACAGCTTCAATCTGTGAACATGTCCCTCGACAGGACCTTGAGACCAGGAGAGCGTGAGCCCTGCTTTGACAGCATCATAGTCTTTTTGCAGTCCTCGTGCGAAGTTTTTCAACTCGGCGACCTCCTGGGACTCGACCTGTTTGAGCCAGGTATCCAGCCGCTCTCCTTGCCGCTCTCGCAGCATCGTGGCAAAGTCCTGGATCAGAGAAAAGGTTTGGGCGATGATCGGGTCAGCTTCACACAGGCGGATCAGGTAGGCGTTTTGCCAGTCCAGCCGCTGCTCCTCTGTAAAGCTCATCCATCGTGCTACCTGGAGTGCTGTCGGCGGACGCCGCACCTGTGCATCCTTTTTGGTCGCGATGGCTTCTGGAGTCGGTTCCACCTGCTTAAATCCTCTGGGCTTGCCTTTCGTCGTGCGCAAGTTCTTGAGGAAACGGCTCACATTGGACATCGAGGCCGCGTATCCTCTTTTGACGATTTCTCGGTAAAGTTCTGAGGCGTTGCGGCAACCATCGTTCCAGCGTTCGATGAGGTAGGGCTTGAACGGCTCGAGCAAGTGCGTGCGCGTACGGCGCGGCGTTCTTCTCTCCGGCGGTTGGTCCATGTGAATATAGCGAGTGACGGTCTGGCGGCTGGTTCCTACCAATTGTGCAATGATCCCCTGATGGACCTTTTTCGCGTGCAGTTCATGAATCTTTCGATACATTTCCACCTTTTCCTGATGGCGCTCTCTGCTCACTTCTTCGAGCCTGCGGGTATTGCCCATAGGACTCTCTTGCAAGGGGGAAGGATTCGTGGCCACTCCTGTTGGGTCCAGCATGGCGGCTTTCAGATGGGATTTCTTGCTGATGAAAAAGCCTTCCAGAGCCTCTCCCAAATTTTTGAGGATGTGCCACCTGTCTGCTACCTGCTGTGCCTGTGGCGCGCCAAGAGTGGCACCATCCGCATAGGACCCACCGCGATCACGGCTAATGATTTCGACTCCCGGATGTTCTTGTAACCATTTTGCCAGGGAAGACGCCTCACGGTCGGGCAAGAGTTCAATCGGAATGCGCTTTTCCAGATCAATGAGGATCGTGCCGAACTTTCGACCCCGGCGAAAGCTCCAGTCATCGACTCCAAGAACACGAGGAGTAGCATGAGCGGTCTCTGGGGCGCGCTCGATAAGTCGAAGCAGTGTGTCAGGGCTGCTAGAGAGACCCATGCCTGCCACCAGGCGTTTCCCTGCTTCTCCACCCAGGGCAAATCCAATGAGCGTGAAGACATCCGTGAGTCTATTGGTACGCCGCGCATAGGGAGCAACGACGGTAGGAAGCCGTTCGGTAAAAATCCGGCGTGAGCATTCTGGATTCTGGCAAAAGAACCGACGAGTATGCAGGTCAAGCTGTACTGCCCAGCCCATCCACGGCAGATCAGCGACCAGACGTGTGTACCGTGAATGCACTTTTTCTGAGGAGTGCAGGCATACTGGGCACTGCGCCTGTGGAAAAGTTGTTGCCACCACGGCTGTAATGCGTCTAGGAAATGCTTGCAGGCAGACCAGATGTAAACACGCTGAATCAGGTAACAACGTTGGATGAGCTTCTGATGCCATCGGGTGAACTCCTTCCATCATCTCCTTCCAGATCGCTCATGGTATGAGTGTAGCAGAAGGATGTTTCCGATGGCATAAAAAACTCATGAAAATCCGTGTCGATCAAGCAAACAGCCAGTATTTTTCATCAAAATGGCGGGAGACCCATGGTGCTTGAAAGGGGTGCGCACTCAAATTGGGCATAAAACGCCAGGAGACTTGAAAATGGCAAAAAATCTGGGTACGATTGACTCATCAGCCTATCTCATCGTGTTGGGGGTACGCGATGCCAAAGCGCAAGCGTGTTCAGAGAGAGCACATCGAAGATTGGCAAACCATTCAACACTATACATTGTGGCCGGAGCAGACGGCCTATGAACTCTTGAGACCTGCCGTACTTTTCGGTGATCCGGCTATTCAACGGACACAAGAGACAGGAGAGCTGCCCTCCAGCCTGGAGCGCAAAGCCGACGCTTTTGATGAGCAGGGCATGGTCAGCTTCTTTGCTTCCAGGCCCCGTAAGCAGCCACTGGAGACAGCACGAAGCCTGCCGCCAGATATGCGCCAGTTGATCGTCGACCTGCGCGTGGAAATGCCCAACATGTCCATCCGTGAAATTGCAGAAATTTGCGATGCTCGTTTTCAGCGGCGACCCTCTTACCATTCAATTAAGATGGTACTGGCTTTTGGCCCGCCTCCATCGATCACTATGCGCCGCTTCCCTCTCTTGAACTCCATTCCCGATCCTGCGCAGTGTTGCCACAACATCGTGCAGCTTCACGCGGAAGGATGGTCCGTTGCTTCCATTGCTGAGTATTGGCAAGGAAGCAAACAGGCAGTGGACACAACGCTGAAACGCTGGGTGCAAGAGGGAGTCAAGGGGCTGGATGACAAGTCACATGCCCGCAAAGCGTCCCGTGTGGTCACGCTTGAAGTTGCCAATGAGATTCGCAAAAAGCAAGAGAATCCGCTCATTGGTGAATGGAGACAGCGTTTACTCGCCGGCTTGATCGATCAGGATAGATCCGTTTTCGTCGGTGGTGCTTCTATGCAGAATCCGGGCTAGCGAAACGGGAAGTTGAGGTGAGCCTTGACACCAGCACGCTCAAGATCGAATATCAGGACACGGAGCTGGCCTTCTACACCATGGAGTGGGCGGAGGAGAATAAACACATCGAGCGCGTAAAAAATCCGCGCCTCATCGAGACGGGCTACCAGTCTCCGCAGCCAAGCTGTGGACGTTCGGACCTGATGAGTGGCTGCTCTTTCTGAAATTACCTGGTTATGCAGCGCGGAAAAAGCTGAGAGGGGTGCCGGGTGTGATCCAACTTCCTCTGCCAGATGGAGGTGGGAATCCGCAGGAAGCAACCTCATCCTAATTCGAGGAGGACCACCTTACAGACTGAGCCAACTTGCCAACAGCGTCGTTGGTTTGACTGGCGTTTGGCGTGTTCCTCACATCCTACGGCTGCGATGCGACGCGCCTTCGAGATCAGATCAGATGACTGCCAAACAACAGAAAGAGGGACACAATGGAGACACCACCCCAAACCGCCCTGGTGCTTGCTGCTCAAGCGGGCGATGAGTCAGCGTTCGAGATCCTGGTGGGCGCATATCGACGTGAACTGCTCGTGCATTGTTATCGGATGTTGGGCTCGCTCTCCGACGCTGAAGATCTGGTGCAAGAGACCTTGCTGCGAGCATGGGAGAAACGTGCGACGCTCACCAGTCCACAATCCTACCGTGCCTGGTTGTACCGCATCGCCACCAATCTCTGCCTCAATCGGCTCGCACGTGCTCCTCGACGTTTCTTGCCATCAGAAACCCATCCACCGAGCGATCCTAGCAGCCCTGCACCTCCACGACTGCGGGAGCCGATCTGGCTGGAACCGTTTCCCGATGATCTGCTCGCAGCTCCTGAGGCTGATCCCGAAGACCGCGCGGAGAGGAGCGAACGAATCACCCTGGCCTTTCTGATGGCGCTGCAGCACTTAACTCCCGTGCAACGGGCTATTTTGCTCTTGCGTGAAGTGTTGGAGTGGGAAGCCTCCGAAGTCGCCCAATGGCTTCACCTCTCGGTTCCCGCCGTCAACTCCGCCTTGCAGCGTGCTCGACGGGCTTTGCGCCAGCGCAATGTTGGAAGCGAGGTGCAAATGGCTCTACCTCGACAAGAGTTACAAGAGCTGCTTGATCGCTATGTAACCCTCTGGGAACAAGCTGACATCCCCGGTCTCGTGGCGCTGCTGCGAGAGGATGCCTGGTTCACCATGCCGCCGCTTCCTGTCTGGTACCAGGGACGAGCGGCTATCGCCACACTATTGCAGACGAGTCTGTTTCCTCCCGGCTTGCAATGGCACCTGCTTCCAACTCGCGCCAACGGCAGTCCAGCGTTCGGACTCTATCGGCGGAAGGCTCTTGCAGACGACTATCAGCTTGTTGGCTTGATGGTTCTGGAGGTGGAACGCGCCCAGATTGTTAGCCTGGTCGCGTTCCTGGAGGTGTCCAGCCTCTCACGCTTTGCCCTGCCGCCCCTACTCGAAGATAGGTAAGCGCGGCTTGGACATTCCCCATTCACCACAGTACTGGTGGATCTCGGGATGTCAAGTACCTAAGGCTTTAGACAGTTAAAGAAGGGAAAGAGAGGAGATCCGCTCCAAATTATGTAGCTCAGCATACTGCTGAGGAGACAGATTGCCTAATCCTTCGTGAGGGCGTTCTCGATTGTAAAAATTGACCCAATTCTGAGCGGCTTGCAAAAACTGGCCCAGGCTGCGATAAGGACGCCGCTCAGCTACAGCCAGCTTAAAGAGGCCCACAAAGCGCTCGGCATAGCCGTTATCGGTCGGCGTTCCGGCTCGACTCATCGACTGCAGAAACCCTTTCTGCAACAGCAGGGTGCGCGTTGGCTCAGCTCCATACTGCTTACCTTGATCGCTGTGCCAGATCCAGCCGGGCGTCTCGAATGAGAGCGTCTGGATCAGCTCCGTCACCAGGTGGGCGCGCATGTGGTAATCGAAGGCCAGCCCCAAAATGTGGCGCGTCTGCTTGCGCAAGGCAAAACATCCCCGCACCCGCGACCCATCGGCCAGGCGCACCTCGAAGATATCCGAAAAGACGACATCGGGAGCCTGAGCGTCCCTGCCCTCACGCAAAAGGTTCGGGGCGGTCTGCGCTGCTTTGCCGGGATAGACGTATTTCTTGCGCTTGCGTCGGGCTGCAAGACCATATTTGCGCATGATTCGCTTCACGCGATTCTTGCCCGTGCCTAGCAGGACCGCCAGCTTGCGATGCCCCATGGTGTCATCGTGCTCATGCAGCGCTTCAATGCGCACCGCCAGTTCCTTATCCATCTTGGGACGCTTCGGATGAGTATACAAGCTACTGCGTGCAATGCCGAGTGTGCGGGCCAACTGGCTTTTGTTGATCGGACTGCCGGAAGCGCACAAGGTGCGCGCCAGTTCCACTTTCTGCTGCTTGGTTAGTGGTCCAGCAGTCCGCGGGATTTTTTTAAGATTTCATTCTGGACCGTCAACTCGCCGATCAAGTGCTTGAGTTCGTCGGGCGACTCCCCAGGAGCAAATCCCTGTGTCTTGCGGCGTGCCTCCTGGTCCCGTTTGTCGGCAAAGACGGCGGGGCCGTGTTCTTGAAACTCCTTGCGCCACCGATGGATCACCGAGGAGGCCAGGCCGAACCTGCGGCACACCTCTTCTATCGTCGTATCGCGCTGGTAGCTCTCTAGCACCACCTTGAATTTAAATTCGGCACTGTACTGTTTTTTCTGTGTCAT

Protein sequences of DBSCAN-SWA_2

>CP035758|2429883:2468736|2434382_2435279_-|QBD76533.1|DBSCAN-SWA
MEERAMFCPACGSKNREAARFCARCGNNLPTPGTALPSRKGDELLRQLDLCIVMDATGSMQDYIEMTRKNLQAFVQKLSLHPVQPQLAYGLVLYRDHPATEKNWVTRRYAFTEQLDDLQQALNEAHAKGGGGDGAEAVVDGLYDACYVMKWRENAHKVILLAGDAPPHGWGNRRDRYPKGCPCEPEHGTVISIAQNARQRGITIFSLGIGDNQAMQKSFEQIAGTSGGRYVPIKSAGKLIDEVLSIMLSEVGKVEIDQVVYRAYQPGATPQAIAALTGLKIGDVDESMNRLHQKRMLQ
>CP035758|2429883:2468736|2432381_2432738_-|QBD83440.1|DBSCAN-SWA
MQVSAGSLLGWVRTCSQALTEVETRIKEGLRKAGVIHQDETDVCVRKHHSYVHVCSTSRLTHFGSHPSRGRSALNDIGILAGFDGTSIHDGYKISPSYRCKNRELSEHHARNNTVFLS
>CP035758|2429883:2468736|2450735_2451428_+|QBD83441.1|DBSCAN-SWA
MGIWQWSDQCHIPEYGDLILAEYTQPFNKNDITYYHSLYQQIVATLGFRPRQVTADAAFDAWDVYQTCAEHGGIAAIPINAHGHPLPNRETDGTPRCDRGLRMFASYQFDHTNGYRAQRFCCPLLYPVPMGQTCEHKQFLKEKGCVKDINIELGGLQRVLLDRTSQTYKTIYRQRTSAERINSQAKSWDIERPKVCNGHSVANLNTLTYILINVRVLQRVYAVNLVYRRC
>CP035758|2429883:2468736|2438271_2438982_+|QBD76537.1|DBSCAN-SWA
MSESTYRSSRYPFVPYKPPRFSIEEQRAGVQLYLNRMSRRRTVREYSDEPVPYEIIEKAIQAASLAPSGANQQPWSFVVVSDPELKRQIRLAAEEEEKESYEHRMSQEWLDALAPLGTDWHKPHIEEAPHVIVVFAQIYGLETLPDGTQHKYKHYYVQESVGIAVGMLLSALTFAGLATLTHTPNPMGFLGQILQRPANERAFVLIPVGYPAEDAEVPAITKKPLDQVAIHFEKKS
>CP035758|2429883:2468736|2467573_2468452_-|QBD76558.1|transposase|DBSCAN-SWA
MPRTAGPLTKQQKVELARTLCASGSPINKSQLARTLGIARSSLYTHPKRPKMDKELAVRIEALHEHDDTMGHRKLAVLLGTGKNRVKRIMRKYGLAARRKRKKYVYPGKAAQTAPNLLREGRDAQAPDVVFSDIFEVRLADGSRVRGCFALRKQTRHILGLAFDYHMRAHLVTELIQTLSFETPGWIWHSDQGKQYGAEPTRTLLLQKGFLQSMSRAGTPTDNGYAERFVGLFKLAVAERRPYRSLGQFLQAAQNWVNFYNRERPHEGLGNLSPQQYAELHNLERISSLSLL
>CP035758|2429883:2468736|2433034_2433475_-|QBD76531.1|DBSCAN-SWA
MITGLGHVAFRITDLEKALDFYCNKLGFREAFRLEREGEPSPWIVYIQVAPNQFIELFPGAQGENPAGGDKVGYNHFCLVVDDLSATLEALEKRGLTISGGPQQGLDHNWQYWLNDPDGNAIELMQIVAESPHAAAEASWVSPAKQ
>CP035758|2429883:2468736|2453769_2454312_-|QBD76547.1|DBSCAN-SWA
MPVAFLTIEQRSRYGCSIGEPSPEQLALYFHLDDRDRTLLAPRRHAHTRLGFALQMRASSTGEGKGSCAFENMVFLIRQTPLLFLFTGFWYRINARAFCPLQWLPRNLTGGAGGNLALMISGFHAPSLSPQIFLLKQCSGLLGQAPHGRPRGSWSARIAGPFALLERIAHGWTREPFADR
>CP035758|2429883:2468736|2459561_2460938_+|QBD76551.1|transposase|DBSCAN-SWA
MAPVFGPYKARVDALLKQNEQLPRKQQYTSPKIFEIIRTEGYQGCESRIRQHVAEWNRTRKQEVFLPLEFEPGQDAQCDWGEAYVVLGGERKKVQIFTMRLCYSRRTFVTAFPTQKQESFLYGHVLAFNHFGGIPYRISYDNLATAVKMAFDRPKQRGRPPRQEQRAFQSFRSHYLFESHFCTVGLQGAHEKGQVEHGVGFVRRNYLVPLPEVASFEELNQLLKERCLADDERRVSRQPTTIGQAWQEERSALRPLPTFDYDCCEITTARLTPYSQATYETNRYSVPVKRARSAVTVKAYPFHVEILDGTTVLARHPRCYGREQDLFDPFHYLPLLEQRPGAFDHAKPLKKWRRDWPESYHLLLRKLREKWPEGRGIQEFVRVLMLHQDYPSEEVAQAVEQALDLGCIHLDGILHCLHQISTSPTSAPLDLSDRPDLDAVGNQPIDLSRYEQLLKQSW
>CP035758|2429883:2468736|2450118_2450796_+|QBD76544.1|DBSCAN-SWA
MRPASPCFDQQMLAQMQDNDPVVLRYRTLFALLDWGLVPERQALPSHPGRRPHPEIAYVKALLIKFDSCTQLRRFLLEHPLLVLELGFRPKPSPHSPYGFDIERTVPCDRWLRYKQQTLNASVLHALFVHTAHALKAAIPGLGEKVAIDVKHLYAWVQENNPSPYVKERYNPQRQPKGDPDCRLGVKRSSNQEQPNGSTKVVKEYLWGYGSGLISAISQNMAISS
>CP035758|2429883:2468736|2442706_2444164_+|QBD76539.1|DBSCAN-SWA
MMKNSFIAMSNQRICCWEGEMRCSSVTLGSPWWPKVRVIKARQDMAGTIAYMAPEQIQGKPRPASDQYALAVVAYEWLSGDRPFHGSFTEIAVQHAVATPQPLRERVPVSPAIEQVIMIGLAKEPKERFSSVQAFASALEQAFQKEQATTVSLQFPSAHVLSPPSLPLTVAPSIATTHPGTSPASVGKHLFSYRNHIAPVSSIAWSPDSARIVSGSSDRTVQIWEAQTGRTETVWNFHSSPVRTVAWTKNGTYIASAGEDTTVSIWETLTRRSVMTYQEHKKCVSALAWAPDSDHIASGGFDKTIHLWSAVTGRKVLTYQGHTRNMGAWVKAVAWSPNGRCIASGDYNGEVFVWDTVTGEYRLHLSASRSVNGLAWSPDSDRIAIACSSGRLLLVQSLAQESTSRHHMNQNEDIGLTSVVWSPDGKFIALGDERHQVHIWDPVSEKLLYTYQGHANRVLAVAWSPDGHQIASASADKTVQVWQAP
>CP035758|2429883:2468736|2433492_2434092_-|QBD76532.1|DBSCAN-SWA
MLRESRNSFPTTFRLPPQIAIIPVIILAILLAACGGGNASTPTDNGPTSNATTDTSTSQPISAQSASNQPTTTSGGQSCDTIIDVNSLSKIMGESMQPAKSMPPLPTIPGVQSTQVCFYTAETAMTDTVGIGLFTGPQTELSTIANGQAISGVGDSAIEMSKGDIMVQKGNNYIYVAVSTQNKGTDTAIQIAQEVLKHI
>CP035758|2429883:2468736|2465235_2466015_+|QBD76555.1|DBSCAN-SWA
MPKRKRVQREHIEDWQTIQHYTLWPEQTAYELLRPAVLFGDPAIQRTQETGELPSSLERKADAFDEQGMVSFFASRPRKQPLETARSLPPDMRQLIVDLRVEMPNMSIREIAEICDARFQRRPSYHSIKMVLAFGPPPSITMRRFPLLNSIPDPAQCCHNIVQLHAEGWSVASIAEYWQGSKQAVDTTLKRWVQEGVKGLDDKSHARKASRVVTLEVANEIRKKQENPLIGEWRQRLLAGLIDQDRSVFVGGASMQNPG
>CP035758|2429883:2468736|2435387_2436014_-|QBD76534.1|DBSCAN-SWA
MFDTQFGLFVIATMAAIVMPGPDIFYVLARSMSQGRRAGLFSTLGIVLGETIHTLLTVLGLAGILAASLPAFLVIKYVGAVYLIYLGIQTIRHRDKFLATKELKSVSSDKRLIVQGMLNDLLNPKTILFYFAFIPQFVRPSIGHVHEQLLGLGLTLAVMDLLFLSCLALFAGSISLWLQRLPQVSKWLAWISGCVLIGLGVRLAVSER
>CP035758|2429883:2468736|2429883_2430516_+|QBD76530.1|transposase|DBSCAN-SWA
MAKQGQKLLRVGAAAHELGLHPMTVRRWIKSGRIQGVQVGRERRIPRTEIERVVGSVDGRLLILYGRVSGHGQKDDLDIQLQRLQVWAATERKGQETLVLSDIGSGLKATRRQLQRLLKLVCEDKVAEVAITYEDRLTRFGQEYLETLFACFGVTLTVLETGEEKTAEQELTDDLLALIASLSGRLYGMRSHKQQALVACAKQVMGEEES
>CP035758|2429883:2468736|2452501_2453596_+|QBD76546.1|DBSCAN-SWA
MPILTKPSNCCLEGFRGNSGTLKSPVQRCSRLDNRHSSIHTGNECGKRKPCLLLTRAYMSGQRMVFARKKGCMLMTTPPGENRLVTDPELLTELVRLDGQGEMLTRSMGGVLPELSRAERNGIQDVLDLACGPGEWVLQLVFENPKMHVVGVDISHRIINYANAKAQEEQSPATFQILDVLSHPLPFADGSFDLVNMRLGFSFLLPGQWPSLLAECLRLLRPGGLIRLCETERSLSNNAVFEKYMTLWTDTFFRDHRTFSPDGLHYGLLPMVKLLLEQAGFMQLRHVPYMIDVSANSPTHQTFFADMLALLQDGLPFLRRMARGPSELEELEAIYDQLRGLVNQEDFCAYWPLMTFLGSKPKMP
>CP035758|2429883:2468736|2463308_2464991_-|QBD76554.1|transposase|DBSCAN-SWA
MMEGVHPMASEAHPTLLPDSACLHLVCLQAFPRRITAVVATTFPQAQCPVCLHSSEKVHSRYTRLVADLPWMGWAVQLDLHTRRFFCQNPECSRRIFTERLPTVVAPYARRTNRLTDVFTLIGFALGGEAGKRLVAGMGLSSSPDTLLRLIERAPETAHATPRVLGVDDWSFRRGRKFGTILIDLEKRIPIELLPDREASSLAKWLQEHPGVEIISRDRGGSYADGATLGAPQAQQVADRWHILKNLGEALEGFFISKKSHLKAAMLDPTGVATNPSPLQESPMGNTRRLEEVSRERHQEKVEMYRKIHELHAKKVHQGIIAQLVGTSRQTVTRYIHMDQPPERRTPRRTRTHLLEPFKPYLIERWNDGCRNASELYREIVKRGYAASMSNVSRFLKNLRTTKGKPRGFKQVEPTPEAIATKKDAQVRRPPTALQVARWMSFTEEQRLDWQNAYLIRLCEADPIIAQTFSLIQDFATMLRERQGERLDTWLKQVESQEVAELKNFARGLQKDYDAVKAGLTLSWSQGPVEGHVHRLKLLKRQMYGKASFETLRKRVLQCS
>CP035758|2429883:2468736|2461906_2462878_+|QBD76553.1|DBSCAN-SWA
MLLVDEQRQRAMLLTVCQFDRTSVEGISLHASLEMDTATTALMRPRTLDLLSKLLQASGGELERICIDVLQDEMLYAQVHLRDQYSQHTIAAGLGDALSLALQLHTPINVSDAVSARRWINLIEYGATLQQQLEAIAPLMQTSPEALFLKKEPWNRDFAQGLQGWQFLGNPECTSYRLDTQATHTGPASLAIDLRESPVHAMAPIGALVHHEGFLAHPYQGQRLRLLTHIKSEHIQQVMMQLHVAGPPAKQLDESTGVYLPTSTYETHTIFHPATDLCDWTRLELVIEVPLDAFTAFFNFSIEGSGKLWIDAVGFECVDTGLR
>CP035758|2429883:2468736|2460951_2461713_+|QBD76552.1|DBSCAN-SWA
MQHQALLESYLRQLRLPTFAQNYQTYAQDAARTDLSYERFLLALCEAEVAAREAHRIERAVAAAKIPVLKDLTSYDFAAVENISKQKVLELAAGGYIAKAETIILIGNPGLGKTHIASGLALAACRQGKHVRFYSVANLINDLQAAQKDLRLSRFTSHFTKLDLLVLDELGFVPFAGEGAKLLFQLCSDLHERVSIILTTNLRFADWNSIFGDERMTAALLDRLTFKSHILEFVGESYRFRSRMRQEEAKDSA
>CP035758|2429883:2468736|2448086_2448602_+|QBD76541.1|DBSCAN-SWA
MGLFTEAEIAYLQKQRLGRLATVTKTGNPHVVPVSFLYNPEFESIDIVGRTLPTSLKYKNIVINGRVAFVVDDIASLSPYLARMIEIRGYAEIVLRDENDPLPHALEMSLEMRRTIARNVAPEMIRIRAKRIISAGLGSNPLSMSRRTIADDGSVTEARTPLQPIQFDAEK
>CP035758|2429883:2468736|2466032_2466221_+|QBD76556.1|DBSCAN-SWA
MSLDTSTLKIEYQDTELAFYTMEWAEENKHIERVKNPRLIETGYQSPQPSCGRSDLMSGCSF
>CP035758|2429883:2468736|2457335_2459141_-|QBD76549.1|transposase|DBSCAN-SWA
MVVCCYVARRTSSMSQTDPTSPFLPLPEGVSITSVEEDATSVLVHIACHHPCALCPGCSCSSDRIHGAYVRTVADLPAGGRRVILKLRVRRFVCPTSTCSHSIFTERLDSLVHSYARMTNRLSETLQTLGFATCGELGERLAPKLGMQVSGPTLLRRMRARIYTPPTSVPIVGIDDWAWKKGMTYGTLVVDLQSRRPIELLEDRSAQTAETWLRSHPEITLVSRDRGGDYAAAAKRGAPQAEQVADKFHLLKNLRERIKEVMDRRHSCLPHEASTRADAIPARARGIKGSPTKESVPPSVEVADEKHYRTIPPTPYWRPPPDNSRQLHRQARRERRYGLYEEVRRLNTLGIGVRAIARQLKVCREVVRRFLKAEEYPEMASHRRGPRGSMLDQYKPYIRERWEQGCRNSVQLYDEIKARGYTGSTSLLRNFLASVRKQYKAARAVEVVHQALTPPIETSASPPPQPLVKRRMSPTRASWLLVSRSEKLDEQQRKYVEQIREGHPDLETAYQLGQQFVMMLAEHRDRDLDAWLQTAEQSILPEFRKMARGIRLDYAAVRAAFSSIWSNGQVEAQVNCLKLQKRIVFGRANFDLLRLRVLCRV
>CP035758|2429883:2468736|2466481_2467498_+|QBD76557.1|DBSCAN-SWA
METPPQTALVLAAQAGDESAFEILVGAYRRELLVHCYRMLGSLSDAEDLVQETLLRAWEKRATLTSPQSYRAWLYRIATNLCLNRLARAPRRFLPSETHPPSDPSSPAPPRLREPIWLEPFPDDLLAAPEADPEDRAERSERITLAFLMALQHLTPVQRAILLLREVLEWEASEVAQWLHLSVPAVNSALQRARRALRQRNVGSEVQMALPRQELQELLDRYVTLWEQADIPGLVALLREDAWFTMPPLPVWYQGRAAIATLLQTSLFPPGLQWHLLPTRANGSPAFGLYRRKALADDYQLVGLMVLEVERAQIVSLVAFLEVSSLSRFALPPLLEDR
>CP035758|2429883:2468736|2447253_2447883_-|QBD76540.1|DBSCAN-SWA
MKRAKHEQPSSRRRRGDALIQAIYAAVLGELADAGFGHLTMDRIALRARTGKMPLYRRWASVQELVLDALTNALEENTTHTPDTGNLREDLIEVHKNIRELMNSPVGTTMRAIIGDRLHHPDLIAAIRTKIFEPHSQILQVLERSTERGEIRREVITPQVCQAGRAMMIMQQLLQGSSPDDTEIVAIVDRILLPALGVHGPTEDAPIRR
>CP035758|2429883:2468736|2449559_2449946_+|QBD76543.1|DBSCAN-SWA
MFKTLLAILGVSCLITGLLIACGNGSNASIGPNPIHMNATNFLQTSITVKKGERITLIDDDLSVPHIIANGTWENGTVKPAREAGAPEINNVQINGNSSETIGPFPSAGTFKLYCTIHSGMNLTVVVQ
>CP035758|2429883:2468736|2459403_2459598_+|QBD76550.1|DBSCAN-SWA
MLTPDERERIRRAYHFDHKSIRQIAHEEQRSREAIKQALEDAPSAPILFLVLAWLLSLDPTKRG
>CP035758|2429883:2468736|2448649_2449069_+|QBD76542.1|DBSCAN-SWA
MLDPKDWNRRLIEEFRANGGKVGGPLEHMSLLLLTTTGARSGKPRTTPMGYFSDGDCLIVVASNRGASTHPAWYHNLLAHPEVTVEVGTETFEAIAIVTKDAERDRLWARAVTLFLTFAEHQAKTTRLIPVITLSRRAS
>CP035758|2429883:2468736|2442333_2442903_+|QBD76538.1|DBSCAN-SWA
MTHRAGQQLGNYRLTHLLGEGGFAEVYLGEHLHLGTQAAIKVLHTQLTSDDIESFRAEARTIAHLIHPHIVRVLEFGVEGKTPYLVMDYASGGTLRKLHPKGTRIPLAPVVSYVKQVADALQCAHDEKLIHRDVKPENMLLGRRNEVLLSDFGIALVAQSSRYQSTPRYGRDDRVYGSRTNSGQAASCQ
>CP035758|2429883:2468736|2436152_2436947_-|QBD76535.1|DBSCAN-SWA
MRWEELSSDQFPAAVKQCEGVCLVALSVIERHGHHLPLGTDMYEGRELLKRAAALEPALIFPDHILTQIPEARHCPGTISIDGDLILRLLDNVCREIARNGLKKIVLVNAHGGNRNLLAFFNELQLYGPRDYVIYVTHPYTNTRGALEVPWEPASDGHAGPGETSMMLAIRPDLVARQQIPSDDESKAREHLQALKAVGVQTGIWWYADYPTHYAGDARPATAEIGEQLLDAAAQQLAQAIKAIKADTETRRLLDEFYAGSQQQ
>CP035758|2429883:2468736|2451590_2452259_-|QBD76545.1|DBSCAN-SWA
MSSLLLLGILLSGLPQARLPAWMSARFWSVLAALSVLLLWQSLLACVGLFVALSPARLLPAAGWRGPWRFSLPPVPPGFLWALGALLALESAAAGNVAASILLSGRRGGDLAAGARGGRSVAVLLSHLSTGSVPGAPAAAPPLFLRHRCPSQAVQWADLAGCAQSWWSRDDEPATGRNAGGRQEENAHTDTMWKTLPLAVEFSTAQRSCAGCLDSSSLLPWI
>CP035758|2429883:2468736|2437100_2437733_-|QBD76536.1|DBSCAN-SWA
MSPLFNDGDVVLFQGDSITDAGRDRLDPRSMGAGYAMIASSWFQALYPSKNVNFLNRGIGGDRAKDLLKRWQKDCLDLHPSWVSILVGINDTWRRYDSNDPTSTQDYEDVYRSLLERTKAALNARLILCEPFVLSVSADRETWREDLDPKIDVVRKLAREYGALYVPFDGLFAQAAAQRESAFWAADGVHPSPAGHALMAQAWLRAVNAL
>CP035758|2429883:2468736|2468427_2468736_-|QBD76559.1|transposase|DBSCAN-SWA
MTQKKQYSAEFKFKVVLESYQRDTTIEEVCRRFGLASSVIHRWRKEFQEHGPAVFADKRDQEARRKTQGFAPGESPDELKHLIGELTVQNEILKKSRGLLDH
>CP035758|2429883:2468736|2455539_2456982_+|QBD76548.1|DBSCAN-SWA
MEERSDAELVRLARAGSKYAFHQLIERYQLMAMGLALRLCREEETARDLVQEAILQAFLSLDHLQDPTRFKNWLYGIVFNVCRNWRRTVAQRPSLSLEAQEEETLHQRLFSYRSGELSVDPLTMIETDELRRLVQEVLQLLSPKNRLVAQLFYYEELSVQAIASHLNISQTAVKNRLHKGREQLRTHLLPLYPELAYRGTNRSVEEKMIPVTVARVVQQDTQARSAVILVDRHKQRAMPLWFPQQENMTLRQHMQMFSMFSQQDRVAEPTTLDLMVAMLTSLGSEIKKVEIDAFQGHILYAQLSLRSSRGKQTLKAHLNDALPLAVQLHCPFFVSGEVWRQRGIDLQGKGATLAEQLDTLIALVSTTFSPLTTKSSGKLDFVDGLADWTIRLDRKQCDYRLDSQTTYTGKPALLITLQDCRGMVQLCHEEDAGRAVPWAPHSPGGLHKNRRCAARQPPSLRDHAFAKSSGAISRFPFGRK

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBD76530.1|2429883_2430516_+|transposase	IS607 family transposase	A0A125SJ73	Acidianus_tailed_spindle_virus	7.5e-28	38.2
QBD83440.1|2432381_2432738_-	hypothetical protein	NA	NA	NA	NA
QBD76531.1|2433034_2433475_-	VOC family protein	NA	NA	NA	NA
QBD76532.1|2433492_2434092_-	hypothetical protein	NA	NA	NA	NA
QBD76533.1|2434382_2435279_-	VWA domain-containing protein	NA	NA	NA	NA
QBD76534.1|2435387_2436014_-	LysE family translocator	NA	NA	NA	NA
QBD76535.1|2436152_2436947_-	creatininase family protein	NA	NA	NA	NA
QBD76536.1|2437100_2437733_-	GDSL family lipase	NA	NA	NA	NA
QBD76537.1|2438271_2438982_+	nitroreductase family protein	NA	NA	NA	NA
QBD76538.1|2442333_2442903_+	serine/threonine protein kinase	A0A0H4Y184	Salmon_gill_poxvirus	1.9e-09	27.8
QBD76539.1|2442706_2444164_+	hypothetical protein	NA	NA	NA	NA
QBD76540.1|2447253_2447883_-	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
QBD76541.1|2448086_2448602_+	PPOX class F420-dependent oxidoreductase	NA	NA	NA	NA
QBD76542.1|2448649_2449069_+	nitroreductase family deazaflavin-dependent oxidoreductase	NA	NA	NA	NA
QBD76543.1|2449559_2449946_+	hypothetical protein	NA	NA	NA	NA
QBD76544.1|2450118_2450796_+	hypothetical protein	NA	NA	NA	NA
QBD83441.1|2450735_2451428_+	hypothetical protein	NA	NA	NA	NA
QBD76545.1|2451590_2452259_-	hypothetical protein	NA	NA	NA	NA
QBD76546.1|2452501_2453596_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
QBD76547.1|2453769_2454312_-	DUF4158 domain-containing protein	NA	NA	NA	NA
QBD76548.1|2455539_2456982_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
QBD76549.1|2457335_2459141_-|transposase	ISL3 family transposase	A0A2L1IVA1	Escherichia_phage	4.0e-05	34.0
QBD76550.1|2459403_2459598_+	hypothetical protein	NA	NA	NA	NA
QBD76551.1|2459561_2460938_+|transposase	IS21 family transposase	NA	NA	NA	NA
QBD76552.1|2460951_2461713_+	AAA family ATPase	U5N3V8	Enterobacteria_phage	2.6e-35	35.1
QBD76553.1|2461906_2462878_+	bifunctional nuclease family protein	NA	NA	NA	NA
QBD76554.1|2463308_2464991_-|transposase	ISL3 family transposase	NA	NA	NA	NA
QBD76555.1|2465235_2466015_+	hypothetical protein	NA	NA	NA	NA
QBD76556.1|2466032_2466221_+	hypothetical protein	NA	NA	NA	NA
QBD76557.1|2466481_2467498_+	sigma-70 family RNA polymerase sigma factor	NA	NA	NA	NA
QBD76558.1|2467573_2468452_-|transposase	IS3 family transposase	NA	NA	NA	NA
QBD76559.1|2468427_2468736_-|transposase	transposase	NA	NA	NA	NA

Sequences of DBSCAN-SWA_3

Nucleotide sequences of DBSCAN-SWA_3

>CP035758|3362951:3435333|DBSCAN-SWA
AATGTGGAATATACGAGACTCGACCAAACGGGGGAGAAAAATGTCTAAAGAGCAAAAAATCTACACGAAAGAATTCAAAATTGAAGCCGTTCGCCTGGCCGAAACGAGTGGCAAGCCAATCACGGAAATCGCACGAGATCTGGGAGTTTCAGATAGCACGATCCACAATTGGCGTAAACAGTTCTCCGAGCATGGCGAGCAGGCATTTCCAGAAAGTGAACACCAGACGCCAGAAGCCGAAGAACTGCGCCGCCTCAAACGCGAACTGGAAGTCGTGAAACAAGAACGAGACATTGTAAAAAAAGCTCTTCGCATATTTTTACGACAAGAGCGATGAAATTCCAGTTTATTGAAGAGCACAAGCGAGAATATGCAGTGAAGACGATGTGCCGCGTGCTTTCCGTCTCCGAATGTGGCTCTTCTGCCTGGCGTAAGCGCCCAAAGAGTGAGTGTGAACAGAAGAATGAAGCACTCACACAGCATATTCGGCAGCTTTTTGAGCACAATCGCCAGATCTCTGGAAGTCCGCGCAAATGGCACTGCTACAGCGACGTCCCAAGCCAGGTGTGATGCATCACACGGATCGAGGAAGTCAGGAGACGAGTCAGGCATAGCAAGCTCTTTTAGCTGCTGCGGGAATCACGTGTAGTATGAGTCGGAAAGGCAACTGTTGGGATAACGCTCCCACTGAAAGCTTCTTTGGGACGCTCAAACGAGAATGGACTCATCGACTAAGCTATCAGACCCAAGCCCAGGCCCGCCAGTCCGTTTTAACTCGAGAGAAACGTTCTCCAACCGCAAGCGCCGTCATTCTGCGCTCGGTTATCTCAGTCCTGTAGCCTTTGAGCAACGAACGCGAAAGGAGCCTGAAGAAAACGTTGAAAACGTTGACGTAACGTATGTTATCTGCTATATTAAAATTACGTTTAAACGTTTTACGTAACGTTCTCAACGTTTTCTTCATCGAGAGTCTCTTTCCTTGACTTGGAACTCTCAAACGTCCTCCACTTTCTCGACTCTCCTAAAACGGGTCAAGCTCAGTCGTTGGAGACGTTGTTATACCCAGACGGTCAGCCAATCGTGCTCCCCCTTCCCACAGGTAGAGAGGCCAATGGCTTCGATAGCTTCGTGTGACCGCTTCGTCTGACGCGCCCAAGCTTCCACAAAGGAATCTAGATGTTCAGCAAAGACTTTGCGTGGGCAAGTAGCAGTATCACAACGAAACTTACGGACATGGAAAAGCAGTTGGACGTGCTGACCTGCCCATTGCAGGTCAGAAACCTTCCGCGTGTAGTAGCTGCAGACGTGGGTAGCAAATTCACTACAGAGAGGGTATGCCTTTATTGGAGAAGTAGTCACGACATGAACGATCACAAGATCGGAGGTCTCAGTAATTTCGGCGATTTCTAATCCAGCCGGAAGAGAAAGCAAAGATGACACTTCCAACATCATCAGACTCCTCGTAGCGGCATAGAATGCTGACCACCAGAAGAGATGCCTCTCATTCCATCGCCCCTAATGTCTTGAATTGAGAGTTTACGGCCACAGAACCGAACCAAAAATGGGCGACAGATATCGCCTCTATTCCAACTACCCAAGGCTGGCTTTACCTTTTGGTGATCCTGGATGTGAGTCCGCTCAGGTATGAAAAGATGGGGAACCCAGCAAGCTAAACGTAACGTTTGACGCTTTATCATTTATTGGATTATAATAACAACGCCAACGTTACGTAACGTAGAAACGTCTCTCATCCTCCTCAGTTCCAATCGGTGGAGGCTCTACAAAAATGGGTCAAAGTCAAGGAGGCCAGGATTGCTATCTCCGTAAAAAAGGGCCTTCCCTGACCTCTGGAGCAGGAAAAGAGCCCTTCTTTCTACTTCTTTTCATCTCAAATTTGTTGAATATTTCTCTTGCCTGGAGGGGATTTTGCTGAGAGAAAATGTTGGGATCCCGTATACAACTGAAGAGTTTTTATGCTTAGTTCAGGGGATGAAACATGAACAACAGGCTAGAGCGAGAGGCAGAGTATGTAGATTACTTTGTTCATCTCACGTCAGTCACCGAAACTCTATGCGGCCATGCCGAGGGCGTTGCGAACAAACTGTGCGAGGAAGTAATGAAAGTAACCAAGGGGAACGCAATAATCGTGATGAATTCGCCTCAGTTAAATCTGCAAACAACCTTATTACGCTGCGATCCCATCTCTGTAAGGTTTCCTGTTAGATTTCGTGGAATCGTCTATGGTGAGATGTATATCAAAGCCAGCCCTCACCATCCCAGCTATCCTTCCTTACCTCTACCTATTGCTCATGCTCTGGCCCAGACCTGCGGCTTGATCCTGCATACCCTGGAAGTCTCTGCCCTGACACTCAACCGCAACCAGGGAAATAAAGGCCTCCATGGCGCGATTACCAAACGTCAGCGCGAAGTTCTTGTATTAATGATGCACGGATACGATCAAGATGCTATTGCCGAGGCGCTTTCCATCTCGCGTGCAACAGTTAGTAAGCATCGTCAGAACATTTATCAGGAACTAGGCGTCCATAACGAAAAAGACGCCCTCCTTGTTGCTTACCAGGCAGGCATAGTTTCTCCTATTGAAGACATTTCTGCGAACGATTAACTCTTCCCATCAGCTAGAACTGGAGTGCTTGGCATGCCCTTTGCACTCCCTCCAATAAACTCTTAGATAATCTTTTCAGGTAATCGCGGTTGCGCCACAGAGATACATGTTGCGTCTGTTGTGCTGGTCTATCTTGACGTTCTGGCTCTACTGGCGTGGTGACTTGCAAGCCTTTTCTGGCTATATTTGCCATGCGGTCTTCCCTTCAATGGCATAAGGAACAGAGATGGATGCTCTGTTATCTCTTGCACCTGTCTATTGATGTTTGCTCTGTTGCTTGAAACCCATTGCCGTGCCTTGAGACCATCTTTGCGTTGTAACCCAGGTAAGGATACCTGAGAGTGAGCGAAAGTCCTGCTCAAAGGGAAGTGTTTTCAAACCTCTTTTCTACAGATAAAGGGGCAGGTGTGGGGGGATTGATCTACCCTTGTGACAGTAACTGCTGCATGAGGCGTGGCTGAGCCGAAACTTGCAGTGGCGAGACAGAAGTACGATAGCTATCACAAATCTGGCTGGTTCTCGTTTTTGGTGGAACCAGCGTGGCCCCAGCAACAGAGCAAAAAAAAAGTCGTCTTACGCCAATGTGAGCCGCTTTAGTGCCCTCATAAGGAATAATGGTGCTCTCACGCCAGGTAGTACACCGGAGACAGTGGATGAGATGTCAATGCACGCCGTTTAACGCAGCCATATATTGCTCCTGCAAGGCAAGTTATTCTGCTGTTAAAACGGTAACGCCATTCGTCAGGATTGCCATTCAAGTTGTATAAAACGCAAAAGTAAACACTCTTATCTGAGCATGACTTTCCAGTCAGATTTATGTACCATTTATTCGTGCAGTATTGAATACAACATCTTTAACCTGTTCTGTAAATAGGTGGGCATTTCACGTCTCCCATATACAGGAAATGAAAAGTATCGTTCAGCACTTTAGGATCACTAATCCCGAAATGTTGTTAATCTGTGGAAGAAAAGGGCTTTATGACCGATAGACATCTGCGTATAGCGGCGCTTCCACCAGAAAAGCGCCATGAACTTCTGCAAAAATTAGCCGAAAGAAAGCAACAGCAGGAGCGTTCAGAAGCAAAGCTTATACATCTCGGGCGGCAGACCAGGAGCTTCCCGCTCTCGTTTGCCCAGCAGCGACTGTGGTTCCTTGATCAGTTGATCCCAGCCAGCCCCCTTTACACCATTCCGTATGCAGTGCGCATCTCCGGCCTGTTAGAACCTGAGATCCTGCGGGCCAGTCTGCAACAAATAGTTGAACGCCATGAGAGCTTACGCACCCGTTTTATCACGGAAAATGGGCAGGTCCGGCAGATCATCGATGAGTACAAGCAATTGTCTCTGACCGTGAGTACTCTGGAAGGAACGCCTGAGCAACAGGCACAGATCATCCAACAGCAACTGCTCGCAGAGGTCCGGCGGCCCTTCGATCTTGAGCATGGCCCACTCATACGTGCCTCGCTTCTCCAGACAGGACCAGCAGAATATATTCTCCAATTGCCTATGCACCATATCATCTCTGATGGGTGGTCCAACGCAATCTTGATGCGCGAACTAATGGAGATATATACATCACTGCTGGATGGCCGGGACGCTAAACTTGATCCGCTGGCTGTGCAGTACCCAGACTTCGCCGTCTGGCAACGTCAGTGGCTTCAGGGTTCTCTTCTCGATCAGCAGCTCACTTACTGGCAAAAACAACTCGCCGGTGTACCGGAGGCTATGGACCTGCCCATCGACCACCCCTATCCGGCGCAGCAGACCTATCGGGGAGCGCTGGAACGGCTCAGACTACCCGTACCTCTTGTCAAACAGATGCGAGCAGCATGTCAGCGCGAAGAAGTCACCTTGTTTATGTTCCTGCTTACGGCCTTTCAGGTTCTACTGGCCCGCTATACACGTCAGGATGATATCGTCGTCGGCACCGATGTCGCCAATCGAAGCCGTCGAGAAACCGAGCAGCTCGTCGGCTTTTTTGTCAACCAGCTTGTTCTGCGCACCGACCTGAGCAACAATCCCACCTTTCGTCAGGCCCTCAAACGAGTACGTGAAGTGGCACTAGGAGCCTATGCCCATCAGGATATGCCCTTTGATAAACTGGTAGAGATCCTGCAACCCGAACGAGACCTCCGCCATCATCCACTTTTTCAGGTCTCATTCGTCCTGCAAAATACGCCGAATCCGTTCCAACAGGCAGGCAACCTGAGCATCCAACCGTTGGAGATCAATAGCGGCATTGCCAAACTGGCCCTGGATCTAACCATCGATGAAAAAGGCGATGAACTGGCTCTGACGCTCCGTTATCAGCAGGATATTTTTGAAGCCGGGACCATGCAACGCATGCTTGCTCATTACCAGCAACTTCTACAGAGCGCAGTCGAACATGGAGAAGATCCTATTGCCTCGCTAAACCTGTTAACACCCTCTGAGCGTCATAACCTCCTCTACAGGTGGAATGTAAATGAGGGGATCGCCGAAGAAAACCAGCATTGTTATCATGAACTTTTTGAACAACAGGTCGAACGTACGCCCGAGGCCAGAGCTGTTATCGACGGTGATCTGGAATTCACTTACGCGCAGGTTAATCGGCTTGCCAATCGCCAGGCCCACCGTCTGCAAGATGTGGGGGTGGAACCTGGAGTACTGGTAGCGCTGGGCATGACACGCGGAATTTCGCTCCTTCTCTCCATCCTTGCTGTCTTCAAAAGTGGCGGGGCATATCTTCCTCTAGAAACTACTGATCCCGCCGAACGGCTGGTGGGCATGCTCAAGGATAGCGGCAGCCAGTTGCTTCTGACTACACGCGCCCTGGCTCCAACTCTGGATGAGGTCTGTCAACAGGGACAGATTGCGCCAAGGATCATGCTAGTCGAGGATCTTTTAGCGGTCGAGCAGCGCAACACAAATCTCACTGTTACCCAGACGCCGCGTGATCTTGCCTATATTATCTATACCTCAGGCTCAACTGGACGGCCGAAAGGCGTGATGATTGAACAAGAAGGCATGCTGAACCATCTGCGAGCAAAGGTGCAGATCTTGCACCTGGATGAGCACGATATTGTGCCACAGACTGCTTCGCACTGCTTTGATATCTCGATCTGGCAATTTCTTGCCGCACTGCTCGTCGGCGGCACGGTCCAGATCTTCCCTGACACCATTACTCAGGAGCCGCAACAACTGCTACCCAGGCTAGACCAGGCCGGAGTTACGCTCCTAGAGGCTGTTCCCTCGGTACTTCAGGTTATGCTGGACACAGCAATGGAGAGCGGCGATGGACTGCCCACGCTTGCATCTATGCGCTGGTTGATCTCGACTGGTGAGACGTTGCCAGTTCAACTCTGCCGGCGCTGGCAGCAACGCTATCCGGCGATACCGGTGATCAACACCTATGGCGCAACAGAGTGCTCAGACGATACGGCTCACCATATCCAGCAACAGCTTTTGGGTGAGAATGAACTCCAGGTCCCCCTGGGTCTGCCCATCGCCGGTGCGCGTCAGTATGTGCTCGATCAGGAACTTCAACCGGTCCCGGTCGGTATTATTGGCGAAGTCTATCTGGGCGGTATCCCGGTTGGTCGGGGCTATGTTGGCGATCCAGTACGTACTGCGGCAGCCTTTCTTCCTGATCCATTTAGCACTCGGCCAGGAACTCGCCTCTACAAAACTGGCGATCTGGCCCGGCTTCAACCAGATGGCAATCCTCTCTTCGCCGGGCGCATTGACGATCAGGTGAAGATACACGGTCATCGCATCGAACTGAGCGAAATTGAGGCCGTACTGGCCAGCCATCCCTGTGTACGTGAATGCACGGTCATTATACGTGAGGACATGACACAGGACAAGGAGCTGGCGGCATATATTGTGCCTGAGCGCGGCCAGACCCTTTGCCCGGTGGACGAACTGCGCAGCTACTTGCAACGCCGACTCCCGAACTATATGCTTCCCACCGGTTTTGTTGAACTGACCACTCTTCCCCTAACCAGCAATGGCAAGCTCAATCGCAGAGCGCTTCCCAAACCAGAACGCATGGCCATCGCCTCGACGGCTGCATTTTTACCGCCTCGCAATGACGTAGAAGAGGTGATCGCTGGAATCTGGTCCGAAATCCTGCAAGTCGAGCATATCGGACGCACTGATAACTTCTTCGCACTCGGCGGCCATTCACTGTTAGCTACCCGCATCATTGCCCAGGTACGCGCTGTTTTTCGGATACCTTTGCCCCTACGTGTCCTCTTCGAGCAGCCTACTGTCGAAAAACTTGCCAGTATTCTGGTAGACCAGGAGCCAGTGCCGGGGCAGGTGGAGAAAATCGCCCGGCTGATGAAACAGGTGGAACAGATGTCAATTCCTGAAAAGCAAAAGAGCCTGGAACCTGGACAAGGGAAGGAGAATGAGTGATGAGCGAGCCCGAAACTCTTCAGGAGATGAACAAGAAGCTGGCCCTGCTTAATCGTTTACTTGAGCAAACGCCAGGGATACAGCAGATTGGCGAGGAGGTGCCTCGTATAACACGGCGCGCAAAGGATGTCGCTCCGCCGCTCTCCTTTGCTCAGGAGGGCATGTGGTTTATTGACCAGTTGCAGATGGATCGCAACGCCTATGTGATGCCTGTAGCTTATCGCATCGAAGGGATGCTGGATAGCTCTCTGCTGGAGCGCTGTCTTAACGAAATCATTCGGAGGCACGAAAGCCTGCGCACAACCTTCGCCCTGCGTGATGGCGCACCAGTGCAACAGATCGCGCCTGAACTCATGATCAAACTGACCGATGTTCATATGCAGATGCTCGATGACGGCGAGCGGGAACAGCAGGCACACGCGCAGATCCTTGCCCTGGCCAGCCAGCCCATGAACTTGCACACCGGTCCACTGGTACGAGCCACGCTCTTTCATCTGGAAAAGGATGTTCACATATTCCTCTTTGTAATCCATCATATCCTGTTTGATGGCTGGTCAACTGGCTTGCTCTTAAAGGAGATCGCTGCACTCTATGAGGCCTTTAGCCAGAAACAGCCCTCGCCTCTGGCGGAACTCCCGATTCAGTACGCAGACTATGCCATCTGGCAACGCCAATGGATGCAGAACTCCAGCCAGCAGGTTCACTTGGATTACTGGCAACAGAAGTTAGAGAGCGCTCCACATCATTTGGAACTGGCTACTGACCATGCGCGACCACTGACCCCGACCTTCCACGGTGATGCCCACACCCTGCGCATATCCAGAGAACTGACCAACGCCCTCCAAAATCTCAGCCTGCAAGCGGAGGCTACACCTTTTATGACCTGCCTGGCGGCTTTCATCATCCTGCTGGCCCGCTATACAGGCCAGAACGATATTGTTGTGGGATCAGCTATTGCGGGCCGTCAGCAGCTTGAAGTGGAACATTTGATGGGTCTCTTTGTTAATACCCTGGTCTTACGCACCCGGTTAGATAGCGAGCAGACGTTTCTGGATGTTCTGGCAGAGGTGCGAGAGACTGCATTGGAAGCCTATACTCATCAGGATGTACCCTTTGCGAAGCTTGTGCAGTTGCTCCAGCCTGAAAGGCAGAGTGGACGCAATCCCTTGTTCCAGGTTCTGTTTGCCTTTGAACAGTTAAGTACTGATCAGGCCACTTTTGCTCAGATGCGCTGGCAGGACTATGCCATCGGCCAGGAGACCACAAAATTCGACCTCTCTTTGTATGTACACCAGATTGATCAGCACTTTGAGATCACCCTTGCGTATAACACCGATCTCTTTGAATCGGCAACAACTCTGTACATGTTGCAACACTATCAGACCCTCCTTGAGCAGATTGTCGTAGCGCCGCAACAGCGGCAGGCAACCATTAGCCTGTTGTCCGACAGTGAACGCAAACAGATCCTGGGGGAGTGGTACCAAACCGCAGCGATATATCCCGATCAAAGCACACTGCAAAGCCTTTTTGAAAACCAGGTGGACCAGGCCCCAGAGCATGTGGCTGTGGTTTTCCAGGACCAACATCTGACCTATCAGGTTCTGAACCAGCGGGCTAATCGTCTGGCTCATGACTTGCTCAGACAAGGGGCTGGTCCAGGCACTCAGCTTGGCATCTGCGTCGAGCGTTCGCTGGATATGCTGATTGGTATTTTGGCTATCATCAAAACAGGAGGAGCCTATGTGCCGCTCGATGCCACCTATCCAGAGGAAAGGCTTGCCTTTATGGTGCGCGATGCCGATGTCCACCTGATCCTGACCCGGCACAATCTGCTGCCATATCTGCCAGCTCAGGCCTGTACCTTTATCTGTCTTGATGATAACCCTGGGAGTGAGCAGGAGCACAATCCTGCTGACCTGGCCTGTGCCGACGATCTGGCCTATATTATGTATACATCAGGTTCTACGGGCCAGCCCAAGGGTGTGAGCGCAGTTCAGAGAGGTGTGATACGGTTGGTTAAAAATACTAACTACATGTGCTTTGATCGTTCTGAGACCTTTCTGGCTTTCGCGCCTATCTCCTTTGATGCCTCAACTCTGGAAATCTGGGGACCTTTGCTAAACGGTGGTCGGTTGGTGATTCTACCACCCGCTATACCTGCGTCAGAAGAACTGACCAACACTCTCACACGGTACGGCGTGACCACTCTCTGGCTCACGGCTGGCCTGTTCCATCAGGTGGTTGAACAGAACCTTGATGATCTCACAACCGTGCGTCAATTGCTGGCCGGAGGTGATGTACTCTCCATTGCCCATGTGCAAAAGGTACTCCGCTCAGGCAAGGTTGAGCGCCTGATCAACGGCTATGGGCCAACTGAAAATACCACTTTTACTTGCTGCTATAGTATGCAGAAGCCTCTCCCTGATGGCCAAACCTCGGTCCCGATCGGGCGACCTATCGCCAATACTCAGGTCTATCTGCTTGATGACGACATGCAACCTGTGCCTGTTGGCATCCCTGGCGAGCTCTACATCGGGGGCGATGGTCTGGCCCGTTCATATTATAAACGGCCAGGCCTGACCGCGGAACACTTCCTACCCGATCCGATCAGCGGACAAGCTGGCGCACGCCTCTACCGCTCTGGCGATCTCGCCCGCTACCTGCCTGATGGAACCTTACAGTTTCTGGGCCGCAACGATCGTCAGGTCAAGGTACGTGGGTTTCGCATCGAACTTGCCGAAATCGACGCTGCTATTGGCCAGTTACCTGGCATTTTACAGGTCTCCACTCAAGTCTATACAGAAAGCGAGAGCGACAATAAGATCCTGATCGCTTATCTGGTTGTTGATCCGGCTCAGCCATTTACCAGTGAACAAATGCGTTCCGCCTTGCAAGAACGGCTCCCTGCCTATATGGTTCCTGCGCTCTTTATAAAGTTGCCAGAACTCCCTTTAACTCCCAATGGCAAAATTGATCGTGAGGCCTTACCTGGCCCGGAGTTTGCGCGGTCCAATATGCTGGAGCACTTTGTAGCTCCGGCAAGCACCGGGGAAAAGCTGCTGGCAGATATCTGGAGCAAGGTTCTGGGGATCTCAGAGATTGGCATCTACGACAATTTCTTCGCTCTAGGTGGCGACTCCATACGCAGTATCCGTATCCGTAGTCAGCTCAAACAGGCTGGCATTGACTTGAGCCTGCAACAGATCTTCCAGCACCAGACTATCCACGCCCTGGCTCAAGTATTGCCAGCAGAGGGAATAAAGCAGGGAGCAGCTCTGCCGACCTCGGCCTTCAGCCTTATCTCTGAAAATGACCGGGCGCATCTACCAGCCGAAGTCGAAGATGCCTATCCCTTAACCAGATTGCAGGCTGGTATGATCTACCATGCTGAATTGGCAGGAGATGGCAGTGTCTACCACAACGTTCTGAGTCTGACCTTGCACAGCAAGCAGATCGACCTTGACCTTCTGGAGCAGGCTATCCTTCAGGCGATTCATCAGCACCCTGTTCTGCGCACAGCCTTCGATATGAGCACTTATAGCCAGCCCCTACAGCTTGTCTATCGAATCGCAAAACCAGTTATTTTTAGAGAAGACATTCAGCATAAGACTGATGCGGAAAAGCAGATAAGCATTGACAATCTAATTAGGTATGAGCGCTCTCATACCTTCGATCTCAACCAGCCCTGCCTGTTGCGTTGCTTCGTCCATTTGCGCTCCGCTACAACCCTGCAATTGACAGTCACGTTCAGCCACACCATTCTTGATGGTTGGAGTCTGTACGGGATCCTCGCTGACATCTTCACTGCCTATACTACCGGGCTCGCAAAGGGGCAATTACCGCCACTGGATACGTTCAAGACATCCTTCCGCGACTTCGTTTATCTTGAACAGCAGGCCTTGCAATCCTCAGAAAACAGAGCATACTGGCAGAAGCAGTTACAGGACGCCAGTATTCTCACGTTGCCGCGCTGGCCACAACGCACAAAAGCAGGCGATCGACGCATCAAGACGCTCCGCTACATAGTGCCGCAAGAGGGCCTCAAGTCTCTGGCTCGCCTCGCCTCGGTCCCTCTGAAAAGTGTCCTGCTGGCCGCGCATAGCAAAGTGTTGCAAATGATCAGCGGCCAGAGCGACATCCTGACCGGCGTAACCACTGATGGCAGACCTGAAGAGCTCGATGGGGATCGAATACGCGGCCTCTTTCTGAATGTTCTGCCATTCCGTATACAATTGTGTGCAGAAAGCTGGTATGATCTGGTACAAAAGTGCTTCCAAATCGAACGTGAGGCGCTTCCTTTCCGCCGCTATCCGCTCAGTGAAATGCAAAACGCCATCGGCGGTCAGGAGCTTTTGCAGACGCTCTTTACCTTTGAACACTTTCATACCATTCAGCAGGCCAACGAGACTGGGGCGATCAGCATTCTGGACTCCATCAGCTATGGCGATGCCAGTTTTGCTCTGAGCGTCGATTTTGGTCTGGACCCTGCCTCGCACCAATTGACGCTGAGACTTGATTTTGCCCGGGCTGTGTTTTGCGATGAGCAGATGGAGGCCATCTGTGCCTATTATCAGCAGATCCTGCATGCTATGGCCACGCGACCAGAGGAGCACCATGAGACGCGCTCTTTCCTTACTTCAAGCGAGTACCAGCGTCAGATTGAGACATGGAATCGCCGTCTAACCGAAACAACCGGAACAAAAGGGTTCTCTCAACTCTTCAATGAGCAAGTAGCGCGAACACCCGACGCTCTGGCAATTATCACTCAAGAACGCCATGTAACGTATCATGAATTGCAGCAGGAGGTTGAACGGCTGGCCGCCCATCTACAACATCTGGGAGTGGGACCGGAGCAGATTGTTGCCCTGCTGCTTGAGCGGGGTATAGAACTGATTAGTGCATTCCTGGCTCTCTGGCAAATCGGCGCAGCCTGTCTGCCGTTAGATCCCACGCATCCAGACAACCGCTATCAACAGATGTTCAGTCAGAGCAGAAGCAGGCTTGTGCTGACCATGCATCAGCATGTCGAGAGGATACAACGGGTCGTCGCAGCATGGCCGGAAGAGGAACGGCCTGCTATCGTACAGCTTGAGAAATTGCCACCACAGAGGGGGCTTCCCCTGGAACCGGTGGCCTATCAGCCGCAGAGGCTGGCCTATATCATGTTTACATCTGGGTCAACCGGCATACCTAAGGGCGCATGTGTCGAACAGGAAGGCATGCTCAATCATATGCAGGCAAAAGTGGCAGATGTCGAACTTAGAGCAGGCCAGAGGCTAGCCCAGAATAGTCCTGTTGGCTTCGATATCGTGATATGGCAATGCCTGGCCCCCTTCCTGGTGGGAGCCACCGTCACCGTCGCTGGAGATGAACTGGCTTTCGATCCAGGCAATCTGCTACGCTGGCTCCAGAAACAGCGAATCAGTGTCTTGCAAGTTGTTCCATCGATGATGCGAGCACTGCTTCAAGAAGTCGAACACACATCTATCGTGCTCCCTGACCTGCACTGGATTGTTCCGACTGGTGATGCCTTGCCCACCGACGTGTGTACGCGCTGGCTGAACCTCTTCCCACAGATCCCGGTACTCAACACCTATGGCTCAACTGAGTGCTCGGATGACCAGTGCCATGTAGCTATACGGCATGCGCCGGGAAGCGACTACGAACTCCCCATTATCCCGATCGGCCATCCCATTCCCGGTATGCGGGCCTATATCCTCGATCAATGGTATATGCCCGTACCAGTGGGGGTTGCAGGCGATCTGTATATTGGCGGCACAGGCGTAGGCCGGGGCTATCTGCACGATCCAGCGAAAACGGCTGAGGTCTTTCTACCTGATCCCTTCGCACGTGCAGCCGGAGCCAGGATGTATCGAACCAGGGATCTGGCGCGTTTCCTGCCCGGAGGGGAGATCGAATTCCTGGGCAGAGTCGATCAGGTCATTAAGATTCGTGGGCACCGCATCGAACCGGGAGAAATTGAAAAGACGCTCCTTCAGCACCCGGCAGTGCAGGACTGCGTAGTTGTGGTTCATCAAGAGGAACAGCGCGACAAAATCCTTGTCGCTTATATCGTGCCGCAGCAGCCCGGTGGAGAGGAAAAGACCGGGATAGGAGAGATGCTGCGACAGTTTCTAGGCGAAAAATTGCCCGCCCATATGGTCCCAGGAGTCTTTGTGCTGCTTGAGACGTTGCCGCTCAATAGCAACGGCAAGGTGGATCGCAAACAACTCCCACCTCCTACCGGGCAGCAGGCGAGAGACGGCGAGGTCTTTGTCACGCCGCGTACGGCGCTGGAACAGATTATCAATGATATTTTTGCAGAGATACTTCATCGAGAGCGGATCAGTATTCATGAGCATTTCTTTGAATGCGGTGGACATTCCCTGCTGGCCACCCAGGTCATCTCTCGCATAAGGTCAATGCTTCAGATCGATTTACCCTTAAAAATGCTGTTTACTTATCCTACGACTGCTCGTCTGGCGGCAGCCATCCTTGAGCATAAGGCCGAACAACGTCAGCAGATCGAGAAGATAGCCCTGCTCCTGGTAGAGTTAGCTGCGCTTTCAGACGAAGAGGTTGACCAGCTTTTCGCCGAGAAGATCGTGACAACAGAGGAGAATAACTAAGTCATGATAAACCCATCCTCCGAGCAAAAGAGGCGAGAGATTGCCAATAAGCGGCGAGCCTTACTGGACATGCGTCTGCGCGACGAAGGCATCAAAGAGTTGGCCAGCCAGAGCATTCGACCCAGAGATCCTCAGACGAGGCCAGTACCTTCTTTTAGTCAGCGGAGCCTATGGTTTCTCAATCAGCTTGAGCCGGAGAGCGGTCTGTATAATATTACTCATGCCTACCGGCTCTCTGGCAAACTCGACATCCTTGTACTACGACGCAGCCTGAACGCAATGCTGCGCCGCCACGAGAGCCTGCGGACCACCTTTGGTATTATCAAAGATGAGGTCATTATTCAGTTGACTGACGCCCAGGAGAGTGAGCTGGAAATCTATGATCTGCGTTCGCTCCCGGAGGTAGAACGGGAAATCAGAGCCAGAGAGATCACCAGACAGCAGGCGCAGCGAGCCTTTAATCTGGCCAGGGGACCGCTTTTACGGACCATGGTTATACTGATCAACAATCAGATGCAGATCCTGATCATCCAAATGCACCATAGCATCTCTGATGCCTGGTCTATGAGTATCTTCTCCAAGGAACTGTCCCAGATCTATACCGCCTGTATGCAAGGGCTGGCATTCTCCTTGCCCGAACTGCCAGTGCAGTATCCCGATTTCGCCCTCTGGCAGCGCTCGCGGCTCCAGGGAGCATATCTTCAGCAACAGATCGACTACTGGAAAAATCAGCTACAGGATAGCCCGGCCTTGCTCCAACTGAGCGGTTCCAAGCCACGGCCAGCCGTGCTAGACCACTGGGGGGCCTGGATCAACTCTACGTTGCCACGCGAGCTGGTGAGGAATCTGAAACTCCTGAGTCAGCGTACCGAATGCACGATGTTTATGATTCTGTTAGCAGCCTTTGCTGTACTGCTGGCCCGCTATAGTGGGCAGGACGATATTGTCATTGGCTCACCTATCGCTGGCCGCACTCTGGCAGAGGAGGAAACACTGATTGGTTTCTTCACCAATACACTGGTCCTGCGCATAAAGCTCCATAGCCAGGACAGTGTTCTGGATCTGTTGCAGCAGGTACGCGAGACAACGCTAGAGGCCTATACACACCAGGATATCCCCTTTGAGAAGCTGGTTGATGCCTTGCAGCCCGAACGCAGGCTGAACTACAATCCGCTCTTTCAGGTTCTGCTGGCTTTCCAGAGCGCACCTGCCTGCGATCTCAGTTTTGCACACCTTCAGGTCGAACCTTACGAAATTGGTCAACAACAAACCCGCTTCGACCTCGCCTGGTACGTCGATGCTCATGAGGAAGATCTCACCATCACAGCCGGGTATAGTCTTGAACTTTTTGATACCGCTCTCATTGAGCAGATGGTACAACACATGGAAACACTGCTCTGGAGCATGGCGACCAACCCTGAACAGCGTTGTGCTGACCTGAAGCTGATTAGCTCAGCAGAAAGCCTGCATCTTCTCAAGGAACGCAATCAGGTCACACGTGTAGAGAGACCGGGCTTGCTGATCCAGCAAATCATAACCCAAATGAGCACTGAGAAGCCGGACCTGCCTGCGCTTGCGATGGGCGAACTGACGCTGACATACGCAGAGTTAAATAGACAGGCTAACCAGCTTGCCCACTATCTGCAAGGCCAGGGAGTCGGTCCAGAGGTGCGGGTCGGGCTTCTGGTCGAGCGCGCCCCGGAGACGATTATAGCGCTGCTCGCCATTTTGAAGGCGGGCGGAGCCTTTCTTCCACTTGACCAAAGTTATCCTCTCAAACGCCTGCAAATGCTGTTGGATGACGCGCAGGTCAGGCTGGTCATCGGTAGAAAAACGCCAGCCTCCTCGCTAGATAGCCAACGGTATGATCTGATCTGTCTGGAAGAAATCAGCGAGATGCTGGCCAGACTGCCGGAAACTGATCCGATAAGTATGGTTGCAGAAGCCAATCTGGCCTATATCATCTATACCTCTGGCTCAACTGGTCGGCCCAAAGGCGTGACAATCGAGCACAGACAAATTATCAGCTACCTTGCCAGTATCCTGGCAAAACTGAGACCCGAGCCAGCGGCTACATTTGCCTTGACCACCACCCTGGCTGCCGACCTGGGCAACACCATTCTGTGGAGTGCTCTCTGCACTGGCGGCTGTCTGCATATACTGACACGTGAGCAGGTCGAAGACCCCATAGCTATGAGTGCCTACCTGCACTGGCATCCTATTGACTATATAAAAATGGTACCCACACACCTGAACGCTCTGCTCTCAATCAGTGAAGCAAGTGTTCCCCTACCACAGCAAGCCTTGATCCTTGGTGGCGAGGCCACAACGAGCGACCTCTTGCAGCGTATTCAGCAACTAGCTCCGGCCTGTTGTATTCTCAACCACTATGGCCCGACTGAGACCACAGTCGGCGTTCTAACCAGACAAGTCGAGGCAAACGAAACCTGTCCATTACCATTGGGGCAGCCACTTAACCATGTACGCATTTATGTGCTGGACCAGCATCTCCAGGCCGTTCCTATAGGGATTGCAGGCGAAATCTATATCGGCGGGGCCGGGGTAGCACGCGGTTACTGGCAAAATCCTGTCAGCAGCGCAGAGCGTTTCCTGCCTGACCCCTTTAGTAATGAAGCAGGCGCACGCATGTACCGCAGTGGCGACATTGCCCTCTATCGTTCCAATGGAGACTTGTATTTTCTGGGTCGGGCTGATTTTCAGGTCAAGATCCATGGATATCGTGTCGAGCTGGCTGAGATCGAAGCACGTTTAAGACAGCATCCGCAGATTAAAGACTGTCTGGTACTAGCCCATGCAGAGACAACAGGGATTTATCAACTGCTGGCTTATATCGTTCCCCAGACAGGTCAGCAACCAGAGGAGCAGGAATTACGCAGTTATAGCACGCAGTACTTGCCAGGCTACATGGTACCGGCCAGTTTTCTCTTCCTGGAAAAAATGCCTCTGACCGCTAATGGCAAAGTGGATCGGCACGCCCTACCCCTGCCTGATCCTGATGGTAACAAGGCGTCAACCAGAAGCTTTGTCGCCCCACGCACAGCGAGCGAACAACAACTTACCACAATCTGGAGCGAGGTTCTGCATAAAGAGCACATCGGTATTCACGACAACTACTTTTCCCTGGGCGGTGACTCCATTTTAAGCATCATGATCATCGCCAGAGCCAGGCGTGCGGGACTGTATCTGACGGCCAAAGATATGCTACAGTTTCAGACTATCGCCGAACTGGCTCCACGGATTAAGAGAGAAATCGTATCAGAGGCCGAACAAGGACTGGTGAACGGTCCGGTGCCGCTGACTCCCATTCAACACTGGCTTTTTGAACAGAACCTGCCAGAAGTGCAGCATCACAACCAGTCCCTCTTTGTACACATCGCCGAGCCGCTCGATAGCGAACTACTGAACATCGCCTTCGAGTACCTGATTACCCATCATGATGCCTTGCGTCTCCATTTTACCAGGAAAAATCAGATCTGGAAGCAAACAGGTGGGGAGCCATCCGAGGCCAGGGTCGCCTTTAGAACCGTCGATCTTGCGCTCATCGATAAGCAAGATCAACGAACTATTATGGAAGAACAGGCCAGGCAGGCCCAACAGAGCCTGAATCTGAGTGGGGGACCACTGATCCAGGCCCGCCTCTTCAAGGCGGGTTCTGCGGAGGATCAATATCTGCTGATTATCATCCACCACCTGATCGTCGATGGAGTCTCCTGGCGTCTGCTGCTGGAAGACCTGCAAAGCATCTACCGGCAACTCAGCCAGCGCCAGGAAGTTCATCTACCTGCAAAAACTACCTCATTTCGCTCGTGGGCCCAACAGCTTGCTGATTACGCCCTGACAGCTCAGGCTGAGCAAGAGGCCGAGTACTGGCTACAAGAGCTGGCTCGTCCCTTTGAGGCATTTCCACTCGACCATCCAAAATGCCCCAACCTGATGAGCACAGAGCGCACCATTACATGCCAGCTCAGTCACGAACAGACTTACCGGCTCTTACAAGATGTACCCGCCCGCTACCGCAGTGGTATGAACGATGGTTTACTGGCTGCGCTTGGCATGGCATATCGAGCCTGGAACGGCCAGAACATTTTGGCCATCACACTGGAAGGACATGGACGAGAAGAGTTGTTCAAACAGGTCGATCTTTCTCGCACGGTGGGCTGGTTTACCAGTCACTTCCCTGTCGTACTGGATCTGGGCGGACTCCAAGAACCGGCAGCAATCATCATGGCGGTCAAAGAACACCTCAATGCTATACCTCACCACGGCATTGGCTTTGGCATATTGCGTTACCTGGGACGGCCAGAGATCCGCGAACGCCTGAAGGCCACGCCAGTTCCAGGCATCAAATTTAACTACCTCGGCCAGTTCGATCAAAGCTTTACCGAGGGGGCGCTTTTTCAGAGAAGCGCTGAAGAAATCACCGGGCCGGATGTCAGCTCACGGGGATCCAGGCCATATATCGTTGAGGTAGACTGTAGCGTTATCAATGGTCAGTTTAACCACAACTGGCGCTATAGCGCCAACCTCCATAATCGAGAGACCATCGAACGGCTGGCCCACTGCTTCCAGCAGGCGCTACAACAAATAAGTACACCTGATGAGCACATGGGCGAGATGCATTTCAGCGCATCAGATTTTCCACTGGCAGATCTGGATGAAGAGCAACTTGGCACGCTGGCCAGTATGATGGCCGATGACAACGAGTAGACCCGCAAGCAAGAACGGAGACTGGCAAACAGGAGGAAGAAGATGAAAATAAAGAATGTTGAGGATATCTACCCCCTCTCTCCCATGCAGGAATTAATGCTTGTCCATACCCTTGCCAATCCCCAAGCACATATGCTCTCCCAGCACCTGCATTATATCCTGCATGGGCAAGTAGACCTTCTCAGGCTCAGAGCCGCCTGGGAACATACCGTGGCACGCCATGCGGTCCTGCGAACCGCTATTATATGGGAGCACATGAAAAAGCCACTACAGATTGTTCGCAGGCAGGTTGAACTGCCCTGGAGGGAAGAAGATTGGCGAGGACTTGCCACACAGATGCAAGACAAACAATTAGAAGCCCTGCAAGCAGAGAATCAGGTGCGAGGCATCGACATCAGTAAAGCACCTCTCATGCGCATTACCGTCATACGCACAGATGAGCAGATCGTCCATCTGATCTGGAACTTCCACCATATCCTGCTGGATGGATGGAGCAGAAATCTCATCTTTCAAGAAATGCTTCAGATCTATTCTGAGCTACAACAGGGAAAAGTGCAGGTGTGGGAGCCTGTACCACCCTATCGGGATTATATCGCCTGGCTAAAGCAGCAAGATATGGAAGCAGCCCGATATTTCTGGCAAGAGATGCTTTCAGGTTTTACCCAACCAACTATTTTGCAGGAGAGCGACGATACGAACCAGCGTATCGAGTCAGCGGAAGGACACCTGAGTGAAGAACTCATCTTGCTAGACCTGCAAACCACCGATAAGCTTGTCGCATTAGTGCGGGAAAATCAGCTCACTATGAATACATTACTACAGGGTATGTGGGCTTTGCTCCTGAGCAAATACAGTGGGCAGAAAGACATCGTTATAGGTATAACCGTCTCTGGACGTTCAGCCGATCTGGCTGGCATTTCCACCATGACCGGGCTTTTCATCAACAACCTTCCACTGCGTATCCAGTTGAGCAACAGTCAACAATGCGTCATGGCGTGGCTCAAAGACATACAAAGCTGGCAGAACCGCATGAGGCTCTACGAATACACACCACTCTCAGCGATTCAGGCATGGAGTGGCATCGACCTCGGCCAACGTCTGTTTGAGACCATGGTCATCTTCGAGAACTATCCCAAGGCCGAGCTGGAAAATGATCCTCATTTGAGCGTACAAGAGATCTCCGGCGGAGCCAGAACTGGCTATCCACTTACCTTAATCGCTGAAGGCGGCCCAATGCTCATCATGGAGGTCTCCTATGAAACCGGACGCTTTAGCCGCGACTTCATCCTCACCCTGCTGGAGCAGCTTCAACATCTGTTGGAGCAGTTCTGCAAGCAGCCGCAGCAGAGCGTGTCCGCGTTGCAGCATCTCTCTGGTATCCAGTGCAACAAACGAGTCCAACTCAAAGAGCAACCGATTGCTCAAATGCCGCAGGAGAATAGCACCGAACAGATCAGGAACAGATCAGGAACACGCTTTGTGGCTCCACGGGACGAAACGGAACAGAGAATGACTGCACTATGGGAAGAAATCCTCAACCAGCGACCCTTAAGCGTTAAAGACAACTTTTTCCGGCTTGGCGGACATTCCTTTATTGCCCTGCAACTCATGGAGCGTATCCGCCAGGAATTTGGCAGGGAACTGGCGCTCTCCACGCTTTTCCAGGGAGCCACAATCGAGAAACTTGCCGCTGCCATACATCATGAGGGCAACCAGGAATCTCCATCGCCACTTGTAGTTCTGCAAGGTCAGGGCCAGAAAATCCCGTTTTTTTGCATCCATCCCAGTGGAGGCAACGTTCTCTGTTACTACGATCTCGCAACGCATCTGGGAACAGAACAGCCATTTTATGCACTTGAAGATCTGAGCCTCTACGAAAAAGAGATCCGCCAGATCTCTATTGAAGAAATGGCCAGCGCCTATATCAAGGTCATCCGCCAGGTTCAACCCGCCGGTCCCTATCTTTTAGGTGGCTGGTCATTTGGTGGGCTGGTCGCCTTTGAAATGGCTCAACAACTCATCCAGCAAAGCAGCTCAACCGCCCTGCTGGCCCTGATCGACAGTCGCCCGCCTCAGGTCAGTATCCGGCTGACAGATGGGAATGAAGTCACCATCCTTGGACGCTTCGCCTATGACGAGGGGCAAAGGAACGGCCTGGAACTGGACATCCCGCTGGCTAACTTGCGTCAGCAGCCCAGGGATGAAGCTCTGCAATACATCCTTACACAGATGAAGCTGGCCGGAATCGTTGGTCCAGAGATTGGCCTCTCATGGGTACATAACTTTGTCAAACGGGCGAAAGCCAAAATCTGGGCCGTTGCTAATTATCAGGCACAGATTTACAAAGGTCACATCACTCTGTTTAGAACGCAAAAGGGCATCCAGCAAGACCTGCAACGGCTGGAACTAGCAGTGGACAAGCAGTATTACGACGAAACGTATGGGTGGAGTAGCCTCTCTAGTCAGCCAGTCACCGTCAAGACGATCGCGGCCACCCATCTGAGCATCGTCATTGAACCTGCTGTTCGGGAGCTGGCACGCCAGCTTCAAACCAGCATTGAAGCTATACAGACGGCGCGTATACAGCGCTAACCAGCCTTTTTTCTCGTAAAGGATCATACAAGAGAAAAAGAGTACAAGAAAGGGATATTCATGAAATAAGAATAGAGCGAATTTGAGCGTATCTATAAAGTAACAGTCATCAATAAGATCAATACTCCATCTGGTTCGCCGAGCGGCCTAACCCTAATGGCTGGCAGGATGCAGGTAAAACCGGCACGAAGGACAACTGCCTGGCCTATATAAAGAAGTCTAGACAGACATGAGGCCATTAAGCTTGCGCCAACGCATGGAAGAAAGGCGTCTCGCGTAAAATCGTGTTCACACCCATCGGCTTTACCGAAGAGAAATGAGTGCGTTAGAGGAGATAAAATGAGTATGCAGGACGAGAAAAAGATGCCAGCCAACCTGACCGGAAGAATAGCGGCTGGCCCGCATACATCGCTCGACGAAGACATCCTGACCCCACAATTTCATTACGACCTGGCGTACCTGCTGCCCTGGTATATACAGATCGAGAAAGTGCTGCTCCTTGAATACAGGCGAATGGATCTGCTCAATCTTGAGGAAGCGCTATCTATCGGCACTATCCTCAACAGCATCAGAAGAGATACTCTCCAGCCTAAGAGAGAGGAGAATATGTCCGATATTGCCTTTGCCATTGAGCGCCAGGTTGAACAATCCCTGTCGCACCTGCCAGGCGCATGGCATGTTGATCGCAGCAGAAACGACTTTCAGGCCTGCGCACAGTTGCTTTCAGGTCGTGAGCAACTTCTGGCCATCATAGATCAGATGGTGAGCTTTGCCTGGGCAGTTCATAGGCGAGCGAGCGCAATGACGGAGATGATCATGCCAGGCTATACCCACTATCAGGCCGCGCAGGTCATCAGTCCTGGCTTCTATCTCACTGCCCTGATCGAAGAGATGCTTGCCTCGACCACTGCCCTGCTTAACATCTACGACGGTCTGAATACCTGCCCTCTGGGCGCAGGCGCGATGGCAGGCCAGCAACTGCCCTGGGACCGGGTACGCATGGCAAGTCTGCTGGGTTTTGACCGACCACAGAGGCATGCCTTGGTCTCGGTCGCCTCGCGGGACTGGCGTACACGTATTGCCGCAGAACTCTCAACTATTGGTGCTACTCTGAGCCGCTTTATCACCGATCTGATCGCCTGGGGCAGTGGACCCTATGCCTTTATTAGTCTGCCTGATGAGTTTTCAGGCATATCCTCGGCCATGCCACAAAAAAAGAATTTTCCCGTCCTTGAACGCTTGAGAGCCAGAACTGCCCACCTGACGGCCTACTACCAGGACTTCATTATGGGTCAGCGCAACACCTCCTATACCAATCTAGTCGAAGTATCAAAAGAGGCTGGAAGCCAGCTCAGCAGTATGTTTACGACTATGGCCTCACTTCTACGCATCTTCACCCTGGTCATCGATCAGATGGAGTTTCAGAGCGAGACCATGCGCCATGCCTGTACCCAGGAATACTTCGGTGGCTTTGCGCTTGCCAACCATCTGACCTTGCAAGCGGGCATCTCCACTCGTCAGGGTCAGGTTGCAGCGGGCAAGTACATCGTACAGGCCATACAGCAAGGCTTCACACCCGGCCAGGGGAGTGCGCACCTCTTACATGCCATCTGCCAGGCTCAGGGATATTCCGCCGATATTGCTTACCATACCTTGCAAGAGCTTTTCGATCCTGAGCACAACCTCCAAGAAAAACACACCTCCGGATCAACTGGGACACAGGCAGTTGAGCAGATGTTGCGCGAACAGACAAACGATCTTCAGCACGTTCAGACAGTTCGGCAAAGCAAACAGTTCCAGATAGAACAGGCATTGCGCGAAATTGATAGACAACTTTCTGGCGAAAAGGAAGTGGAAGACCTATGATCTCAGGCCATTTAACCGCACCAGGGAGAGACACGTCCGGCAGATTGATTGGCACAGGCAAAGCATTTGGCACATTTGGAGAACTGTTGCAAGGTTCACTTGGACCTGAACACAACAATTTTCTGGTTACTTTCCCGATTGATTGCTACTCATACGCCACGTTTATCGCAGAGCCGGACAACACGCGAGTCAGCGTGTGGCCTGACTTTAAATGGAAAGCCCAGACCCTTGCCACTGCTATTCTAAAATACTATCATCTGCAACCGGGGGGCAAACTCAAAATTGTCAGTGAACTGCCCGTGGGCAAAGGTCTGGCTAGTTCCTCAGCCGATCTGGTAGCCACAGCGCGGGCCATCGCCTCATGCTTTCATCTATCCATTCCCCTGGCGTTGCTCGAACAATGGATGCAGCAGATCGAGCCGTCAGATGGCGTGATGTATCCCGGTATTGCCGCCTTTTACCATCAGCAGGTTCGGCTACACACCTTCTTCGGAAATCTGCCCTCACTAACCATTATCGGTTTGGATGAGGGTGGTTCAGTAGATACCATTGCTTTTAATCACTATCCAAAACCATTCACTCAAGAAGAGGTGGCAGAATATAAACGCCTGCTGGAAATGACCGCCATGGCCGTGCGTCAGCAAGATCTGGCCAGCCTGGGATACATAGCGACCCGCAGCGCCCAGTTGAATCAGGCCCTGAATCCCAAAAGAACACTCAAGAATCTGCAAGAAATCTGTCAGAGCATCAGTGGGCTAGGAGTAATCGTGGCCCATAGCGGAACATGCCTGGGCCTTCTGCTCTCTCCGCAATACCCTGCATACCGAGAACAACTCAGACAAGCTTATGATCAAATCTCTGATCTGGCCAGTACCGTACTGGTCTATCATTCGTTATGTTGCGTCAATACTACTTTGAGAGAGCATATCTCTTAAAGGAGAGGAGAGCACTATGCTGTACAAAAACATCATCGAGAGTATAGGCAAAACCCCACTGGTGCAACTGCAATTGGATGGAGGGGCGCAAGGAAATGTCTATGGCAAACTGGAATTGCTCAATCCCTTTGGCATGAAGGACCGGGTAGCCAAGCAGATTATCCTGGATGCCCGCAGAAAAGGCGTGCTCAAAGATGGTGCTCCCATTATCGAAAGTTCATCTGGCACTATGGCCCTCGGCATAGCACTGGTAGGAACGGCTCTTGGCCATAGCGTCCATATCGTTACAGATCCACGGATCGATACCTTGACCCTTACCAAGTTGCGTGCCCTGGGCTGCACAATCCACGTTGTAGATAAAATGACCGACAAGGGCTGGCAGGGAGCACGTCTGGAACGCCTGCATGAATTGATGAATCTCCATTCTGGGGCCTTCTGGCCACGTCAGTATGAGAATCCAGGCAATCCCTATGCTTATACTGACCTGGCCAACGAATTGATCGAGGATCTGGGGCAAGTCGATATCCTTGTGGCCAGTGTGGGTAGTGGAGGCTCCCTGAGCGGAACCGCACGAGCACTACGCCAAAGGCAGCAGAGCCTGCATGTCGTTGCGGTAGATGCCGTGGGCAGCGTTATTTTTGGGCAGCCAGACTCCCCCAAACGTCTGCAAAGCGGCCTGGGAAACAGCCTGGTTCCGAAAAATGTCGCGCATGCCCTGGTCAATGAGGTACACTGGCTCAATGATGCGGAAGCCTTTGCCGCCACGCTGGATCTAGCCCATACCGAAAAGATTTTCGCAGGCAATAGTTCAGGCTCGGTCTACGCCGTAGCTCGCTGGCTCAGCCATACAGTCAAGGCCGGGACTAACATCGTAGCCATCTTCCCCGATCGGGGCGATCGATACCTCAACACCATCTACAACGAGTCCTATCGCATCGACAAAGGGGTCAATCAAGGCCATCTCCCGGCCCAACCAGAGCAGGTCACTCCCGATACAGCTGTGCAGAGCTGGTCCTTTACTCAATTGAAACGTTTGCCGCTTGGCGCTGGCGCACGAGCCTGAGCAGTAAACGATAACTTCCGGGGCTGGATATCTCCCTGGTCAAGACCTATGTGATGAAAGAGGCAGTGACATGTCGCCAAAACTTGTCTTTGTAGAATCGAATACCACAGGCACCGGCCTGCTTGCCTTGAGTAAGGCCAGGGAAATGGGCCTGACGCCTATCTTCCTGACCAACAATCCACAACGTTATCCTGGCTTAGAACAACAACCCTGTCGGGTTATTATTTGCGATACCAATTCCGGTGAGCGCCTCCAGGAGACTATCGATGTACTCGATCCCGACAGTATCTGTGGAATCACCACAACCAGCGAATTTTACCTGGTTAACGTGGCTCAACTGACACAACTGCATGGTCTGCCCGGTAATCCAGCACAGGCAGTAGCTCGTTGCCGCAATAAGGCAGCCATGCGCCACTATCTTGCCGCAGTAGGTATGCAGCAACCGGCTTTTGTTGAGGTACGCAGGTTGAGCGATCTGGACACGGCCATTGAGCAAGTAGGCCTGCCCTGCGTTGCCAAACCAGTCGACGATACTGCCTCAAACGCAGTACGCTTCTGCGCCAGCAGACAAGACGTGGAGGAACAGGTAAGCAGTATACTGTCTCTGACCAGAAATATTCGTGGGCAGCGGACTGCTCAGGCAGCCCTGCTGGAAGCCTTTATTGATGCCGCCGAGTATAGTGTAGAAACCTTTAGCTGGCAGGGCCATACGACCTGCCTGGGCATTACTGAGAAACACCTGACAGCCTTTCCCTACTTTGTAGAAGAGCGCCACTTCTTTCCAGCAGCACTCTCGCCAGCGAGTGAGCAAGAGATGCGCAACACGGTACTGCAAGCACTGGAAGCTCTGGGTATCGCTCATGGACCGGCCCATACAGAGGTCAAACTTACCACGCATGGTTGCCAGATCATCGAGATTAATGCACGTCTGGCTGGTGGAATGATTCCCGAATTGATCCGCTATACCAGCGGGATCGACCTGATAGAGCAGCAGATAAAAGCGGTTACGGGGCATGAACCTGATCTGAACCTCAGAGCGCAAGGATGCGCGGGCATTCAGTTTCTGGTCTCAAGGGAACAGGGCTGGACGAAAAACATTGAGGGACTGAGCGTAGCCAGGGCTGTCAATGGGATTAAGCAGATCACCTTGACCAGCGCTCCCGGGAAGCAGGTCAATCCGCCTCGGAGTGCCTATGACCGCCTGGGATATATTATTGCGCATACCGCCAGCTATGAGCAAACAACTTGTGCCTTACAGACCGCGAGCTCACAAATCCACCTGGCCGTGCGCAACGATAGCGGAAACAGGGTAGTAGAGGAGTTTCATGTATGATCGAACTGCGTAGCGACACATTCACTCTGCCCACAGACAGCATGCGAGCTGCCATTACCCAGGCCGTCCTCGGTGATGATGTCTATGGGGAAGATCCCACTGTGCGTCGGTTAGAAGAGCTGGCCGCGTCCATCTGTGGGAAAGAGAATAGTTGCCTGATGCCCAGCGGCACCATGGCCAACCTGGTCGCCCTGCTAGTTCATTGCCCCAGAGGTTTCAAAGCACTGGTCGGCAACGAATCAGACATCTACATCTATGAAGCAGGTGGAGCTTCGGTGTGCGGAAGCATCATGTACGAACCGATTCCCACACAGCCAGACGGGAGCCTGCTAATCAGCGATCTGGCCGCAGCAATGCCGGAGGAACGAGACGATCCACAGTACGCCTTGCCAGCATTGCTCTGCCTGGAAAACACCCATAATCGCTGTGGTGGCGTTGTTCTCGACCCTACCTACCTGCGCCGGGCCGCGGCCTTTGCCCACGAGCAGCAGATGAACATTCACCTGGACGGAGCCCGAATCTTTCACGCCGCTACCGCCCTGCGCGTCGGTGTAGCTGAGTTGGTTCACGAGATGGACTCGCTCCAGTTCTGCCTCTCAAAAGGGCTTGCTGCACCCATTGGCTCCATGCTGGTAGGTAGCCGGAGCTTTATTGAGCAGGCCCGCCGCATGCGCAAAATGCTTGGGGGAGGCATGAGGCAGGCTGGCATTATTGCGGCGGCAGGCCTTGTTGCCCTGGAACAGATGACAGATCGTCTGGAGGAAGATCATCGCCATGCTCGCCTGTTTGCTGAACGGCTGGCCGAGTGGCCAGAGATAGCCATAACGCTCAAGAATGTCCAGACGAATATCGTCCTGTTCAAGGTCATTCATGAGCGCTTTACCTCTAAAACAGTCATCGAGGCTGCGCATCAGCGTGGCTTGAACTTGAGCGAACTGGGGCATGGCAACATACGAGCCGTATTCCACTATGGTATTACAGAGAAAAATGTCGAGCAAGCACTTGAGATTATCTCAGGGCTACTCCACACTACCAACCAGGGCTGAACTCAAAAAGAGGATAGCAACCATCTCATGTATGCCCACTCAAGGGCCTGCAACCAGAAAAAAGGAGTTAGCATGTTTCACCCCTATAACCCGGCTCCGTTTGCATCCGGGATCTCGCCTCTCCAACGCGACAATACCGCTCCGAGGAGCGGACTATCCAGCATGCAACAGCTTTTCGAAGAACAGAAGGAGCGCAGCCCCCAGGCCCTGGCGGTCTGCGATCAGCAGCAAACCCTGACCTACTGCGAACTTGATGAGCGCGCAACTCGCCTTGCTATATACCTTCGTATGCTGGGCGTGCAAGCGGAAATGCGTATTGGCCTGTGCTTGCCCCGGCAATTAGATTTGCCTGTTGCTCTGCTGGCCATTCTCAAGGCCGGTGGCACCTCGGTTCCGCTTGATCCAGCCTATCCTCAGGAACGGTTCCATTTTCTCCTGGAGGATGCTCAGGTCTCATTCGTGATTACGAACTCACAGATCCTGCAGAACCTTCAATTGAGCGATACGGAGACTTTGCAGTATCTCTGTCTGGATCTGCTCACCGATCTGCCTGGGTTAACCGCCGAGAATCTTGCCCGGCTTGCACCAATCTACCCTGAACAACTTGCTTATGTCATCTATACCTCTGGCTCGACCGGTCAGCCTAAAGGTGCTGCCATTACGCATCGCAGCGCCTTCGCACTCCTCCAATGGTGCCAGCAACGCTTCTCTACCGAGGAACTGGCGGGTACACTGGCCAGCACCTCCATCTGTTTTGACCTTGCGATCTTTGAGTTCTTTGCTCCCTGGAGCGTCGGTGGTTGCGTTCTGCTGGTCGAGAATGCTCTGTTCCTGCCCTACTTGAACACGTCCCAGCCTGTCACGCTTATCAATACGGTCCCTTCAATTCTGCGTGAGCTGTTGCGCCTGGGGCCACTGCCTCAAAGCGTCAAGACTGTGTGTCTGGCCGGTGAGGCCCTTCCCCTGGCACTGGTGCAGCAACTGGCCGAACAGCGACAGATTTCTCGCCTGTACAACTTGTATGGACCCAGTGAAGATACTACCTACTCAACAGAGGCTCTTCTCCCCCTGGATATCCAGAAGGTGACTATTGGTTGCCCCATCACCGGTACCAAGGCATACATACTCAATGAAGAGGGGTCACGTGTAGCCCCAGGCGAGACTGGTGAACTCTATCTCGCTGGCTCAGGACTGGCCCGTGGCTATCTGAATCGACCAGAATTGACAGCTGAACGCTTTGTACCCTGCCCCTGGGAACCGGCTGGTGGACGCATGTATCGCACCGGCGACCTGGTTTGCCAGGAGCCTGATGGCCAGCTTCGCTACCTGGGGCGGAGCGATCAGCAGGTCAAGTTACATGGTTATCGCGTGGAACTTGGCGAGATCGAAACGGTCATTAACCGCATGCCTGGCATCGCTCAGGCTATTGTGATGGTTCGTAATCGCCGCGAAGACGACCAACGTCTGGTTGCTTATATAGTAGCATCAGATACCAACCATGGACCTGATGCCGAGCAACTGCGCACCTGGGTAGGCCAGAGATTACCTGCATATATGGTACCTGCCCTGGTTCATGAACTGACCGCCTTCCCCTTGACACCAAACGGCAAAATCGACCGCAAGCAATTGCCTGAGCCAGATTGGTCTATCCTCCATGAGATACGCAGCCAGGGAACCCCACCCGCAAGCGAGGAAGAACGGCAAATCGCAGCCATCTGGGAAGAGGTTCTGGGCCTGAAGGGCATCTCCCGTGAGGAAAACTTCTTTACCCTGGGCGGCCACTCCCTACTCGTGCTGCAAGTACTGGCGCGACTACAGGAAAGGCTGCATGTCCACGTACCTGTCCGTGTCATTTTTGAACAGGCTACGATCACACAACTCGCGGCCTTTATCTCCGCGACCCGCTCAGACGGTTTTACAGACAGTATACCCTTTGTCAAAGTACCGCAAGACCAGGTTATCCCCGCATCCTCGTCACAGGAACGAGTCTGGTTTATCCAGCAGCTCATTCCTCACAATCAGGCCTACCACTTTCAGGCAACCCTGAGACTGAATGGCAAATTGCATCTGAACGCCCTGGAAGCGAGCCTGAGCGAAATTATCAGTCGTCACGAGATCTTTCGCACTACCTTCCCCAATCAGGGTGGCAAACCCATCCAGGTTGTTCATCAAGCTGAGCCGGTGCATGTGCCTATTATCAATCTGGAGCAGGAACCACAAGAGCAACGCGAAGCTACTCTCAAAGAGCTGATTGCCAGAGAACTCGACCGGGACATGGACATCAATCAACTCCCTCTGATTCGCTGGACCCTTTTCCGCATCAGTGAACGAGACAATCTTCTCCTACACGTCGAGCACCATCTCGTCCATGATGGCTGGTCCTTCAACATCTTTTTACGCGAATTTGTTGCACTTTATACGGCGTCTATCGAAGAGCGCCCCTCGCCTCTGCCAGAGCTTGCCTTCCAGTTTCGTGATTACACCTACTGGCAGCAACAATGGCTGCAGAGCCAGGAAGCTCGCGACCAGATCGCCTATTGGAAAACACAATTAGCCGATAGCCCTCCTGTGCTGGCCATGCCGACAGATCATCCACGTCCCGACGTACCCACATTCACTGGTCGAGTGCCACGTATTGAATTGCCAGTAGAACTCTGCCGCAAATTGCGAGCTTTAAGCCATGAAGCCGGCGTCACGCTGTTCATGACTATGCTCGCGGCTTTCCAGATCCTGCTCTATCGGTACACCAATCAACCGGATCTCTGTGTGGGCACAGCCGTAGCCAACCGCAACCGCAAGGAAACGGAAACGATCATTGGTATGTTTGTCAATAACGTCACGCTGCGCACCCGCATCAATGATCATGAGAGCTTTTTTCAACTGCTCAAGCAGGTAAGAACTGTCACGCTTGACGCCTATGCCAACCAGGATGTCCCCTTTGATAAAGTTGTCGAAGCAGTTCATCCTATACGCGAGTTGCGCTATAATCCCCTTTATCAGGTGATGTTTAGTTTCCACGATTCACCTCTTCCCGATATGCGGGTTCCGGATGTCCATATTACCCTTACCGAAGCGATCAGCAATGGCTCGGCCAAATTTGATCTGGCCATCATTGCCATTCCACGCGCTGAGCAGCGCGTCGGGCAGCACCACACTGAGCATGCAGATGCTGAAGGCATTACTTTACTCTGGGAATACAGCCATGATCTCTTTACCGATAGCAGCATGGAACGTATGATTGACCACTATCAACGTCTCTTAACTGATATCGTTGCTGATCCGACGAAAAGCCTGAGAGACTTCAAGCTGTTATCTGAAGAGGAAACGGCACAGGCCATCACCACCTGGAACAACACCTATCAGCCTCGCCCCCTGGCATTGCCGCTGATTGCGGAACAATTTGCTATGCAGGTCGCCCGAACGCCCGACAATCAAGCCCTGAGCTTTGCTGGTGAGCAAATCACCTATTATGAACTTGATTGCCGGGCTAACCAGCTAGGGCATCATCTGCGCTCTCTGGGAGTGGGTCCAAATACGGTGGTGGGTGTTTACCTTGAACCATCGCTCGAAATGATTGTGGCCGTGCTTGGGTTGCTCAAAGCCGGTGGGGTTCTGCTGCCAGTCGATAGCAGCCTGCCCCTCGCTCAGATAGTCTACCTGCTCCAGGACACGGGGGCGAGGACCATCCTCTCGCATACCCAGAACAGAGCAGTGCTCCAGGCGCTAGCACAGGAATTACCGCAGCAACTAAGCAATCTGGTCCTGCTCGATCAGTCAGAGGAGACGTTCGATCTACCCGCCGAACTTCAGGTCTGGACAAGGAATGATACCAAAGGCTTTCCTGACACGTCCTGCCCATTGACAGTTAAAGGAACTGACCTGGCCTATATCATCTATACCTCTGGCTCAACTGGTAGGCCAAAAGGTGTGGCGATTACACAGCGCAACATTGCGGAGTACTTCGACGCTGCCCTGGATCACTATGCGCCTCAGCCCGATGATCGCGTCATTCAAAATCATCGGCTGAGTTTTGATTTCTCCATCTGGGAAATCTTTGGACCATTGTTGAGAGGTGCCAGTCTATACCTGGTTCCACGCCAGGTTTCACGCGACATTGGAGCGCTTACCCAGCTTATCAGCGAACAGCAGATCACCATTTTAAATATGACGCCCTCGCAGTTTACAACCTTGCTTGAGTACGTTCTGTTGCTTCAGCCCACGGCCTTACAGTCCCTGCGCCTGATCGTCATGGGAGGAGAGACCTTCCCTTTGGCTCTGGCCAGAAAAGCGCTAAATATCCTACCAGAAAACTGCAAGCTCTACAATGATTATGGACCAACAGAAGCAACCATTGGTTGCACCGCCTTCCACGTCACACAGGCCAATCTGGAGAAGTACAGCAATCTAGCCAGCGTGCCTATTGGCAAGCCAATGAACAACATGCAACTGTATGTGCTGGACAACGCCATGAACCCGGTACCAGTCAACGTAGCAGGAGAACTGTACATTGGAGGTGTCTGCATTGGATCGGGCTACCTCAATCGGCCAGAATTGACCGCAGCATGCTTTGTGGTCGATCCCTACGGTCAGGAGGCGGGAACAAGGCTCTACAAAACGGGTGATCTGGCTCGCTATCTACCCGATGGGGCGATAGAGTTACTAGGACGTATCGACGATCAGATCAAATTTCGCGGCTTCCGCATCGAACTTGGAGAGATCGAGGCGGTATTGAGAGAGCATCCCCAGGTGCAGGAGGCGGTGGTCATCCTGCATAAACGGGCAGAGAATGACCAGCAGATAATCGCCTATATTCACATGGGAAGCGGGCAAACTGCCTCTTTGAACGAGCTGCGCACCCATCTGAAAGCCAGGCTGCCAGAGTATATGATCCCGTCTACTTTTATCTTCATTGAGCAGATGCCCTTGAACACGAATGGCAAAATTGACCGCAAGGCTCTGCCAGAACCGGATCAGACTGCTAGAATGTCGGCAGAGGTGCAGTATATCGCGCCACGCAATCAGATTGAGGAGACAGTAGCCATGATCTGGGCGGACATTCTCAATGTCAACCCCATCAGTACCCAGGCCAACTTCTTTGAGTTGGGGGGCCATTCCCTGCTTGCGACCCAGGTTGTATCCCGACTTCTGGAGGCGTTCCACATACTCATCCCAATACGGAGTATCTTTGAAAAGCCCACTATCGCCCAACTCTCTGCGGAGATTGGCGATACGCTCATCGAGCAGGCTGACAACGACACTCTAGAGAAACTCCTTATCGAATTGGAGTCATAAGCCGCATGAACGCTCCAACCAGAGTAGCCTGTCTGCATGCCTGGCCCAGTGTTATGCAAACTGTCATGAAGCGCAAAGTAACTTGCATCTCGGGCTTACATGGAAAAAACGAACAAACCGCCGTTGTTGTGAAGGCGATACGGCACACTCTCAAACAGAGACTGCATAGATGCTCACGTAAACTTAAACAAATGAACGCGGCTGAACCACCTGGCCAAAAGCGCGATCATAGTCCTACCATCGAGGTACTTGCGACAGCTTAATAGAAATGGGCGAGATATGGGTAAAGTAACATCTTACAAGGTAACAGGCAAAGATGAATCAGCTAAAAGCGTAAAAAGCTTTGAAGATCTCAGAGCGATAGGAAATACAGAACGTGTTGAAATGGAATACGCCTATGGGCCTGATCTTTTACCAGCAAACCCATGGTCAAATAGCGGTATGTGGCGCTATCTTGCGCTGTTACCAACTCAGGATGAAATTTTGTATCCGCTGGCAGTCGGAGGAACTCCCCTACTCGCTCCGCTGCCGCTACGACAACTTGCAGGTCTACCAGGATTATGGTTGAAGGATGAGACACGCTCTCCAACTGGCTCGAATAAGGATCGGGCCACAGCTCTGAGCCTGGAATATGCTCTCCATAATAAGATTCAGACCATCAGTTGCGCTTCAACAGGGAATGTTGCCTTATCTTTGGCAGTGGGGGCTGCTGCCTGTGGACTTAAAGCTGTTATCTTTGTTCCCGCTAGTATCCTGGATAGTAAGTTGCAGTATATGCGCGTGACTGGTGCTACGATTTTCAAAGTAAAAGAGGGCTACGAAGCAGCGGTTCGCCTCTCCAGAGAGGCTGCACATGCCTTTGGCTGGTACGATCGCAATACTGGCTATAATCCTCTTACGCTGGAAGCAAAAAAGACGGTGGCCTTTGAGATCTGGGAACAGATGGGGCATCAGGTTCCCGATAGCGTTGTAGTGCCGGTCGGCGACGGAGTGACATTAAACGGCCTTGCCAAGGGTTTCCGAGAGCTAATGTTTTGTGGAGCGACCACAAAATTGCCGCGCATTATTGGAGTGCAAGCAGAAAACTGCCAACCATTAAAAAGAATGTGGGAAGGTCACTCCGTATTCCCCTGCGACCATAAGTCAACTATTGCTGATGGTATTGCTGTAGAAGCTCCTATTAACGCAGGTATGGCTTTACGAGACATCCGTGAAAGTAGGGGAGGTTTTGTGGCAGTTTCTGAAGAGGCTTTGCTTAATGCTATCGCCCTCCTTGCTACTACGAGTGGCATTTTAGCCGAGCCAGCAGGTGCGGCAGCCCTGGCCGGGATCCGCCCGGCTGTTGAACAGGGCCTTTTAAAGGTGCATGAAACGTTTGTGGTGCTGGTAACAGGATCTGGCTTCAAAACACCGCAATATTTGCGCCCGCCAACTCACTCACCAGTCTATGAGATACTTGCTGATATCAATGAACTCAAGCAGATCCGAGCACACTCCAATTGCAAATGAGCATTCCCCATTTGGTAGCGTCAGAAAGGTGAGATAGACGAGACGCTATCAAATGGGGGAATGAAGATGTCCAGGGAACAAAAAATCTACACGAAAGAGTTTAAGATCGAAGCTGTCCGACGAGCAGAGGCCAGCGGCAAGCCGATCGTCGAGATCGCACGGGAGTTGGGAGTCTCTGAGAGCACGATTCATAATTGGCGCAAACAATTTCCCCAACACAGTGAGCAGGCGTTTGCGGGCAGTGGTCATCAAACACCAGAGGCCGAAGAGCTGCGCCGCCTCAAACGAGAGCTGGAAGTCGTGAAGCAAGAGCGTGGCATTGTAAAAAAAGCTCTTCATATATTTTCACGACACGAGCGATGAAATTTCAGTGTATCGAGATCAAGAATATGCAGTGAAAACGAGGTGTCAGGCGCTTTCTGTCTCTGAATGGAGGCAAGCAAGTAATCCATTACTGGATTTGAGCCTTTTTCCCTACTCGGGATCGATCCAGAATTCACAGAAATAGCGTCGCAAGTAATTCCCTGCTGGAAATCAGGCCGATGCCTCCTCTTTTTGCAGAAAAACACTGATTGAGCTTCACTTTTTCTTTCCTTCTCTTTCCAGTATTTCTCTCGCAAGGAATTCATTGCTGGAAAACTGCTTTTGCCCAATCATACCTCTTGACAAAAGAAAAACTCTTTTGCAGAGTTGGGATATCAACACACACATTCCACTCATACAAAGGAGTTTCCTGCTATGATACCCTCTTCGGCTCACTTTGACCAGTCCACTCTTGCCCTTTTGCTTTCTCATGATCTCTTGGTCCAGTAGTATCGTGCCTTCTTCTCGCACCTCGATTGGTCCCTCGTCGAGCAGTGGCACGCCCAGCGTTCTTCTAGGGGTCGGCCTGCCCATCCTGAAAGCGCCTATCTCAAGGCCTTCCTCATTCGTATCCGCGAAGGCCTCAGTTCTACCAGCCAGCTGCGTCGCTTCCTGCTGGCCCATCCCCTCCTCGTCCTCGATCTTGGTTTTCACCTCGTGCTTGACCCCCTCCAACTCTACGGCTTCGACTGTCACCAAACCTTGCCGTGCGAGTTCTGGTTTCGTCAGAAACTGCGCTGCTTTGATCCCTCCTTGCTCCAAGCCCTGCTCCAGGCCACCGCCGCGCTCTCAAGCATGAGATCCCTGGACTCGGTGAGGTCGTCGCTTTTGACGTGAAGCATATTTACGCATGGGGAAAAGAAAACAATCCACGAGCCTCTGTTAAGGAACGCTACGACAAAACCAAAGTGTTGGCAGGTGATCCTGACTGCAAACTCGGCGTCAAACGCTCGACCAACCGAGAGCAACCAGATGGTTCGACCAAAGAAAAGAAAGAGATGCTTTGGGGATACGGCTCTGGCGTCGCTGCTGCTACTACTCCTGACTATGGTGATGTTGTCTTGGCTGAACACACCCTTCCTTTCGATGAAGGCGATGTGCGTTATTTCCAGCCTCTGTATCAACACATTCCCAACCCATATCACTGCTGATGCTGCTTATGATGCCTGGTATGTCTATGAGCAGGTAGCCCGCCATGGCGGCATTGCTGCTGTTCCCCTCAATGCACATTCCTCCCATCTCAGCCCTCGTGCTAGTGATGGCGTTCCTCTCTGCGCTCAAGGCTTGCGGATGGTTCCTCTCTTCCAGTTTGCTCATCCTTCTGGCTATCGTGCCAACACTTCCAATGCCCTCTGCTCTTTCCTGCTCTCACCGGTGAGACCTGTGACCATCCACAATTTCTCAAAGGGAAGGGCTGTGTCAAAGATCTCAATTGGGAGTGAGGAGGACTCCAGCGCGTGCTCTTGGATCGAGGCGCCCCGCTTTACACAGCCATTTACTCTCAACGCACCAGTTGTGAACGCATCAACAGCCAAGCCAAAGAACTCGGCATCGAACGTCCGAAAGTGCGCAATCGCCGCTCTGTTGCTCACCTTAACACGTTGATCTCTGTGATTAGTAACGTACGAGCTCTCAATCGAGCCAAATCCATCAATAGGAGACTTCTACTTATGAATTAGTTGCACCCCTCCTCCGATTAGGTCCCGCGGAAGAGCGATGCTCCTAATTACTTACATGATCCCAATTGAGTACAAGTTCCTCAGTTCCCACTTTCAGTGCCCTCAGTCTTTCAGTATCCTCAGTAGAGAGATGCACCGATGCGTTGAGCCGCAATCCAGAGGGTTTCTTGCACAGCATCTTCAACATCCTCAGGAGTCGCGCAGAACTTGCGCGCAAAGCGAGTCACAGATGGATGATACTTGCCCAGCAGTTGTTCTATCGCTGCGGGATCACCGTCTACTGCATCGGGTATCAGTTGGGCGTCAGGTACTGAGTTCATGATGGACGCTGGCTTGACATGAGCTTGCGTCCAACCAGAGCACAGGCAGGGCACCATCCGAAGAAGCCGGTCGCAGCCACGAAGAGGGCTGAGACAAGCAATACCAGGGCGAGCAGCACTGCCCATGCCCCATGCATGAGCTGAAGATACACCCACCCAGCACACACCGCCAGGCCACTGCCTACCAGGACGCGTACTATCCGCTCGAAAGTGGGGACATTTTTCACATAGACCATGTTGATCCTCCTTTGTACCTCTGAACGTTCTCTTGATTCAGATCGTTCTCTCTCTAGTAAGAGACCAAAAAAGGGTGAAAGGATTCATCTCCTGGAGATTTCTCTGAAAATCTCTCTGACAAGTACAGCTTCAGTTGTAAGAAAAGGCCACAGGAAGTCTGCGGAGTCCTGATCGAAGCCGGGCTCCTCGTTTCCATGTCCCATGACCAGATGTGGTGAGTGGAGATGAGGGTTATTTCTCCAGACGCCCGATGATGATCCGTTGGAAAGGGGGCTCCTCAGGAGAGTATGCAATCATTCCTCAGTTTACGCCATCTTCACGCAAGTTAATTGTCAGTTGACCCACTAGTACAATTGTCTGAGGTAGTACGCTGGAGCTTGTTGATGACTCAGCAGCGCCTCATATACTTGCGAACGGGATCTGGGACGATGGAAGCCCCAAATCCATGCAAGAGAGCGAAGCACCAGCTATGAATAATATGCAGATCAGCGGGAATGGAAGTCAGATAACCGGACCTTTCACGACAGCTGGTACGGATCACGTGTATTGTTCAGTTCATCCGGGAATGAAGCTGACCGTCATTGTGCAGCATGAGAGCAAAAAGCAGAGAGAGATCGCTTGCCCTCTGCTTTTTGCCATAGTTGTGAGAATCCGGCGCTTATTTGTTGGTCATTTGTGATTTCGAGATACTATACTGTTCGCCAAGGATTCCGTTAAGCGGTGGTCTCCTTAAGCTCTTTATTCACCATCTCTGGTTCACTGACTATCCGGCGGAAGAACAGCGCAGCCTCTTCTTGAACAACATCGCGAAAGCTCTTTGACAGATCAAATCCATGGGATTGCCCGCTGTAAAGGTGCAGATCGCACTGAACGCCAGCAGCCAGCAGCGCCTGATGGAAACGCACGGTTGGCGGATAGGGTACGTGGATATCGGAGGTTCCGTGCAGCAAAAGAGTTGGCGGAAACGCAGGCGAGATATATGAGAAAGGACTGACCTGCTGCATAGCCTCTGCCGTTGCGTTCAGCCCAAGCAGCGGCCAGGACGGAAAGCCCTCCTGATTGAGCTTATGTTGTTCCCACGCCGCCTCGTCGGCGGGCGGATAGTGATTGCCGAAAATTGCTTCTTCTGGATCGCGAAAGAATACCAGCGCCGGATAGACTGCCATGGCCGCCGCCACACGAGTAGAAACGCCAGCGCAGCCACCCTTGCCCTCAAATTCAGACTGATCGGGTGTTCCAGCCGCGATCAGGGACAGGTGTCCGCCAGAACTATATCCCTGCAAGACGATACGCTCAGGGTCGATGCCTAGTTCCTCAGCATGAGAGCGTGCCCAACGAATGGCTGCCTTCACATCGTGCAGCGGAGCAGGCCAAGGTGCTTCTTGAACGAAGCGATATTCGACGGTACAACAGGTAAAGCCAAGGCTGCTTAGTTTCTCCGCATGAGGGCGTAGCATATGGCGGCTATTCCGGCGCCAGCCTCCTCCATGAACTAGTAGCACAGCCGTTCGCTGGTTCTTGTGCGGATCAGGAGGAAAAATATCGAGTCTCAGTTCGCGGTCATTGCCTAGACCATACACGACATCAGCGTGAAAAGCCATTATTCTGCCTCTTTCTGAAAAGCGATACTTCTTAAAACAGAACATATACTTTCCTTATTCCATCTGAGTGGTACCAAAATCTCCATGACGCTCCTTCTGATCCGCTTTCATCCCAAGCTTTTCTTTCAATCCGTCACAATCCGAGCCTTGTTCAGAGCCTGTCTAAAGCCTGTGGCTATCAGGAAAACCCCAGCCGCCTTCAGCAACAGCTCTGGGAGAATCCCATGTTTGCGGCGAGGAGATAACCACTCAGGCCTCTGGTTCCCAGGAGATGGGATTAGCCCGATGAGCAAGATCTTGAAAGGATTGCTCATTGCAGCAAAAAATTTTCGCTCCAGCACCTTGAAAACAAAAGCTTCTATTACCGTCCATACAAGATCAGGAGACCGAAAATATCGAAACCGATAAGCATGCATATCAAGGCGAGGCCACAGTAAATAAGCCATTTCCTCCATCTTTGTTGAATTAGGAGGATCTGGCTCGATGTTTCTTGCGGAAGAACAGTCGCATTGCCATTGAGAGGTGGGTATTGCTCATCAAAGAACATGTTCAATGCACTGCGGGTTTGCAGCAGTGACGGCAGCAAATGTGCAAGACTGTACAATTGATTACATTGAGCTCTGAGGCGTTCGCTCAAAGCATTTGAAAATGCTGCATGAAGTTCATCTTCACAAAGGAAGGAAAAAATAGATGAGGCTACCGGTATTAGCTGAGTAGCATAGGGACTTTCTGTTTGTAATGTATCGCCATGTTCTGCTCGCTCTAATTGTTCTGTGCATGAAGCTTTTTCCAACTGAAGTATCATTTAACTTAATTTGTGCGCGTTTATCCCAGATAACTTGCCAACGACTGGCTTGAGAAGCACGTTAAGACGAGAATTGAGCAAAGTTTCTCTCACATAACATGGCGTAGCACCTTAGCTCATCTACTAAGACAAGGTTTTGGATCGATGAAATGTCTGATTTCTCTCAGAATGTGTATGACTCCCATGATACTCGGAGGGAGCACCCCTTTTGGATGCGTTCTATTGATCTGGCAAAAAGAGAAAAAGATGAAGGGAGAGCAAGATGCGTGGCTGCGCTTGGAGAGACGATAGAGTGGTGAGATGATAGAGGAGGAAGAAACAGCGTTTTTTAGAAGAGTCACCAACCAGGAGCATATGCGATGTATCGAACACGTCTGTATCGAAACTATCCCTCCAACTTGACGGATGAGCAGTGGGAGATCTTAGCATCTTTGATCCCACCTATCAGCCCCAATGCTGCTTTTTATCTGCATGAACGGCGTTCGATTGTTGACGCGATCTTGTATGTGTTGCGCAGCGGCTGTCCTTGGCGTAGCCTCCCCCATGACTTTCCAGCTTGGCAGACCGTTCACCACTACTTTCGGATGTGGCGACGTGCAGGCATCTGGGATCAAGTGCTCACTGCATTGCGGATGCAGGTTCGGGTCAAGCAAGGCCGAGATCCTGAGCCAAGTGCGGCCATCATCGACAGTCAAAGCATCAAAACCAGCGGAGTGCGTGGCCAAGAGAAAGGTTACGATATGGGGAAAAAAAATCTACGGACGCAAACGGCACGCCCTTGTGGATACCCAAGGCCAACTGCTGGAGGTGAAAGTGACAGGAGCCGAAATCTCTGATCAAGCGGGAGGCAGAGACTTGCTCTTGCCTCTCAAAGAACGATTTCCTAGACTTCTGCTCCTCTGGGGGGACAGTCATTATGGAGGTGAGTTTCTCAAATGGCTCAAATACACCCTGGGATGGACAATGCAAACAGTCAAAGGGCTTAGTGTACCCAAACGCGGCCTGCTCGTCCCGGAAGGAGAAGAGGTGGATTGGGCACACCTCTTTCCCTCTGGCTTCCGCCCTCTCCCCAGGAGATGGGTCATTGAACGCTCATTTGCCTGGATCGTCAGATGGCGTCGGCTCTGCCGCGACCATGAGGGCTTGCCCCAAAGCAGCGAGGCCTTCATCAAACTCTCTGCCAGCTACCGCATCTTGACCAAGCTCGCTCCACGAATTCCATCGTGATGGGAGTCATACACATTCTGAGAGAGGTCGTCACCTTTCCTCTCATCTATAAGAGGAAGGCTATCTGTAATGGCACCGACGCCGGCCCTCCTGACGGCTCTCCAAAGTGCAACGAACACAGGCATTGAACGCTTGACGATCATCCGTCCAGCACGAGAAAAGGAGATGACGCAAGCGGAAGGAGCGCGTACTTCGTAGATTGTCTTTCTACTAGAAAGAGATTTTTCTCTCCCAGGGTGAGCAGAACAAGCTTTCCATGTGCTTGGCCATTGAATGCACTGGTGAGAGACAACACATGCAAGATTGGAAGATAGGAAAACGTTTCGCGGAAAACAAGAAAAGGAGAAGGCTATGGCAAATTTCGACGGGGAGTTTTTTATTTTTAACCGCAACAGTGGGAAAGTTATTGTTGTTGCCGGGGGATCTAGGGACAACGGGGCAAACATCTGCCAGTGGCAGTATTCTGGGAACGATGATCAAAAATGGACCCTGGAAACTACAGATGGGGAGTACTACACGATCAAGAATCGTAACAGTGGGAAAGTTATTGTTGTTGCCGGGGGATCTAGGGACAACGGGGCAAACATCTGCCAGTGGCAACATAGTGGTAATACTGATCAACAATGGAGTCTTTTGAAGATAACAAAATAAGATCCTAACGAACATGGTATGTATGCAGATGGCCTACGGAACAGGTGCCAATGCATACATGCTCTTTCGCTCATGATCTCGGCATGGTCATAAATACAGCGGCAATTGTAGATCATGAGTCTTTTACGCTCCCCTACTGAATAGATACCATTTTTAGCCATGCTTGCTACCAGTTATCCGCTGTCGAGCATCTCGCCTATCTGGGGGCGCAGCAAGTTGACGATCCTTTCGCTCCCTCTGGACTGACGCGATAGTATCAGACGCGCTTCTGGGCACGGGTCCATCTGGAAGCGTTTCATCCCCTCTTTGAAACACGTCGTCGAACGCTTGCCACACCAAAAGATTTTTTATCACTGTTATCGTGGGGGCAAACAAACATAGCGCAAGCGCTGGTTACTATCGCGACTGAGCAAGAACGGCTATTCTCTTCTGCTCTCTCAGAGTAACTGTTCTCTCTTCCCTGAGAGGGGAAACGCTACGTAAGGTGACACCAGCCGCAAGATAGCTGCCAATACAATATAACGAGCAATAGAAAGATCAAGGGCATTTTCCCCACTTTCTTGGATGTTTCGAGAACACATCTCCAATTTCTTCGTTATTTCGCCACCAAAGACACAATCCAGATCAAATCCGTCCACCTCTATATGTGTGATTTGACTTGTCATAGTCCTGCCGCTGTTTTGGGCTGGATCAAAGGTGTTCAGCCCGGACCGAAGTTGATGTATCAGGCATTTTCAGCTATTTGCGAAACGCGAAGGTTGAACAAAGCGGGTTACGCGCGCTTCAGAAACTTTTACCTGTATGGTGAGCGTAACCTTGCCGGAGAAACGGCTCTGGTCAATATTTTCAAGATGTCTTGACTCTTGAATATGATCAGGAGCGACTGTCGCGGTACTCGGTGGAGTGGCAACCGGATGATCGCCATCTTTCTCGTGTAGGTGCCCCTCGGCTCTATCAACACGGATATCAGTCTGCGCAACTGGAGCTGTGGCAACCAGGTGAAGTCGAGTGGTTTGTGATTATTCGGGATTCCTCACCCGCACGGCGGCGCAGGCGTGCAGCTCGTATCCTGGTGATCCAACCTCCTTTACTCTCCGATGGAACACAAAGATCATGATGCAGAGACACCCTGCCCTATGATGCGCAGATTAGGTGGTAAATGACTTGCGCATGTGGTCACTTCTTACCCTCAAACCGACACTTTTGCGCCTTTCTGGTGGGCAGTCGTGATCCATCATCGCCAGAATATGGCGCGCAGCCAGCGGATCAGGATGTCTGACTACGGTACATTCACGATACGGCTGAGGCGAGCAAGAAGTGTCTCATCGGGAGAACAGGGAAGCAAGCGTAGAGCAACGGTCGGTTGGCGGAGGCAGAAGGAGGGATGTTCTTTTCAGGCATCCCTCAACTATCTCTTAGATTCCTATGGCTCCTATGAGGTAGGCTCCTGTGAGATCGGTGCTTTGGAGGTGGGCTCTTTGGAGGTTGGCACATCCGAGGTAGGCTCCTGTGAGGTCGGCAATTTGGAGGTTGGCTTCTCCGAGGTAGGCTCCGCCGAGGTTGGCATTGTTCAAGTTGGTGTGATGGTCGAAGCCGGCTCCCCTGAGGTAGGCTCCTGTGAGGTCGGCACATCCGAGGTAGGCTCCTGTGAGGTAGGCTCCTGTGAGGTTGGCATTGTTCAAGTTGACGCCTGTGTTGAATTCAGGTCCTATGAGGTAGGCTCCTGTGAGGTCGGCGTTGCTGAGATCAGGTGTAATCGATGGATTCTGCTCTCTCCAGGCATTCCATTCCTGCACTGACTTTTTGAGAAGATTCACGTGGTTCTGATTTGCCATGCTGTTTTGCTCCTTGTTTCTTTGGTTCTTACGAGACAAAAACACGCCTCTGTATATAGAGGCATTATCGTCTTTTCAGTATATCACTGGCAGATGGCTCAAAGCGAAAAGATTTCCCGGCCACTTTTGTCGCAACGGAAGGTTTCAATAGGTGTAACCACTCATAGTGGTCGGTATGGAGCGAAACCCCGCCAGGACCTTGGTAATGTCCGTGTGCAGTATCTCTTGCAACAAAACACGCTCAAAAGCACGGAAGTGGGCAGATCTTTCTGCAACGAATATTGCACACCTTTTTATCAAGGTCCTGGCGGGGTTTGAGAGCCCATGTGTATATTCGCTCTCCTGCCTCTGAGGTGGAGCAAGGCTAATCATGGTAAGGTGTCGTGCCTACGAGCTTCAGCACTTTTATTTCATCAAGCTCTCCCCATTTTGCCTCTAGTACTCTATTGCCGTTGTAGAGGCTAACGCTCTTCTGGATATTGCCCCCCAAGGATCGCCGATCATCTGGCAGACACAAGCATGAGAGAACGTTCTGGGTATGGGCTTCTGCATGAGCTACGGCTGCATGCTCCTAAGTGGCGCTTGGACTTTGCAACTGCTGAAGCTCGCTCTCTTGTTGCTGCCGATGAGCTCCCCAAACGTGCAACGGTTGCGCATTTGGGGACAAGTGGACAAGCGCCTAGCCGCGATCTGGGCCAGTGTCAGCAGGAAGCCATAGGAACGCTTGCCCTTCTTCGCAGCAATGAAGGTGCTCATCACCCATTGCTGCCTGAGAGGCGATTCATCTGCTTGTGATGTCGTCCCTCTCTCAGGCAACTTTTCTCTGCGTTTCCCCCATGCACAAGGAGGCTCCACTCCTGCTCCATGTGCAGCTCTCGTCCTTTCCTCAAACTCCCACCTCCCCTTGCTTGCCACTGGTAGCTCTATTTCGAGCAAGCCTGCTAGCTTCTCCGTCAAGCTCTTCATCTCCTCTAGTTATATCGGGACCCCATTTTCTACGAGGTGAGGGCCCAAGCAGTCATAGAGCGCTTGGAACAAGTCAGCGTGACACCGTAGTATCGTCCTTATGAGCCACTTGGCAGAAGAGGATGAACACTCTGAGAGCGCTGTGATTTTATAGAAATTATGGCACTCGCTCTTCCCCATATCATGACAGAAGCTTGAGACCAGAAGCGGCTTTACACTGATGAGCTACGAAGCATTCTGTCGTCTGTCAGGGCCTCGATTCACATGTGTGACCCATATGGCGGCAGTGAGGAGAGGTGCCTGAATGCACCTCAAAAAGCAGAACTTATGAGCCGATTTTGCTGCGCATGCCGAACGGCAACCCCAACAAGTCGTCCAGAACTGCTCCCGTTCCATAGAGACCATCAAGCCGCAGTAATGCAGACGCTTCCGGCAACTGGTGCGCCCGTAGGTACGACTGGATCGTTTCCTCCGCGCGGCGTAGCTCCTTGCGGTATTCGCCATTGCCCGGATTGCCAAACGTGCCGAGCCATTGAGCGGTATGGGCCTGCAGAACGGTCGTCCGGGTTCGCACAACTTCCCCTCGTTTGCGACCCGTGTAGCCTGCAGCCGCACACCTCATCAAGACGACGTGCGGCTGCAGGCTGGCCCTCCCTCTTTGACAAGGCGCGCTGGCGGGCCGCCTCTCGTGTCCCATCGATGTCGAAGACCTTCCACAGCTTCCCTGTTCGGTCAGTCAGCCCGCAGGGGCGCTGCGGCAGCCGTCTGCTCGCCGCTCCTGCAGATCTTCGAGAAAGAGCGTGCGCAAGGCTTCGATTGGCCCTGCTGTCAGAGCCGCCAAAAAGCGCGAGAGGGTCGAACGAGCTGGAAGTTGGTCACGCTCAAACAAGGCCATGAATGGGGCGGCAAAGGGCCGAAGCCGCTCGTAGAAGGTCTCCAGGGCGCATTGCAAAGTGCACTCGCTCACTGATCCTGGCCAGAACACCGTGCTTGCGAAGATATTCAACAATCAGCACAACTTCGCCAAACCAGGCTGGCACAGTGGGAGCCGACTCAGCGGAGGTCTGAATAGTGAGAGAGGGCTGATCGGGACCGTTCATATATAGAACACGTGAGGAGAGCTCCTTTCTGTGCTTTCATCGTTCTTTCGCCTTCCATTTTACCTGGCGAAGCCAAGCAAGGACCATGCTCTGTCTCACTCCTCGACCCGCGTTCCAATGGTCTTTGGATTCGGATGAAGGGTGACGATCCGCAAGATCCCCGAGCCCGCGTTGCTGAACTTGTGAGGCACACCGGCTGGCCCGATCACGACATTTCCAGCTTCGACTTCTAAGCTGCTCTCACCCACAGTAAACGTGGCGCGACCCTCCAGGATGAGAAAGATCTCATCATACGGGTGAAAGTGGAGTTTAGGGCCTTCGTCAGGGGGGAGCTGCATCCAGAAAAACGAAAGGGGAACGCCTCCATAGTCCTTTCCTTGAAACAGGTAGCCATTCTGAAGCTGCTCCTTGGGAATGATAGGTGCCATATGTTTTTTCCTTTCATCGTCAAATGGTGTCGAAAGCAAAACAGACAGGTTTGCAGTCTTGTACAGAGAATCCGCTCAGCGGACGCGAGAACTCCCCCACAGAACCAGCGAAAAGCGCGAAAGCAGACCTATTCAAGGTACCCAAATCAGAGAGCTGCCACAGCGGGAATGACCTCTCGGCCAATCACCTCCAGCGGGGTGATGGTATCGATCTGTGGAATCACCCCAAGCACTGTTTGTATTCCCATTCCGGCGAGCCAGCGCAGGTGCTCGATGAGCTCGCTCGCTTTAGAACCATCCTTGCCAACGTCAAAGGCGAACATACAGGTCTTCTCAATCGTGTCATACTCGCGCTTTTCCGTCTCACAATGCTGGCGCAGGATCGCCAATTTCTTTGGAATCTCTTGGCCGGGTCGCAGGTTGCACGCATCGGCGTAGCGCGCGACCAGGCGCAGCGTTCTTTGCTCACCACTTCCGGCGATCAGAATCGGCGGATGGGGTCGAGTGAGGCTCTGTGGAACGTTCAGCGGGCGCGGGATCTGGTAAGAGGTTCCCTCAAAGGGGCGCTCGTCTCCCCGCTCGCCGTGCCACATGCGCAGGCAGATCTGGATCGCCTCCTCCAGCATCTCATAGCGCTCTTTCGTTGGAGGGAAAGGCAGGCCTGATCCACGGGCTTCCTCTTCGTAATCTCCCGCGCCGATGCCCAGCCACGCCCGCCCCCCAGAAAGTACGTCCAGCGTGGTCACAGTCTTGGCGAGTCGAATGGGTTGCCAGTAAGGCGTTGCTGTGACCATCGCAATGAGCTTGATCCGGCGAGTATGAGCAGAAAGGTACGCCAGCGTTTCATAGCAGGAGAGTTGCTCGCGCTCCACCCCACCGAGATAGGCGGATTGCCAGACATGATCTCCGAGACTGATGCGATCAAATCCCGTTACGTCGGCTATCTGTGCGATCTTGACCAGCGTGGGGCCAATCAGGCTCGCTCCCCCCTGCCAGGTAAAATCGTTCATATGGAGTCCCAGTTTCATAACATCTTTCCTTCCCGTTTTTCAGCATGCTCACTCTTCGCGTCAAGAGTGTTACCCTATTTCTCATTCTGCACGCTTTCTCCTCCCGCCTAGTGTCCCGAAGAAGTGAGGGAGAGATGTTAGTATAGCAACCTGAGATGACAGAGGTATGAACTTTTTCCGCGATTTTGTCATCAATTTGTCACCTTGCTGGGGATTGTCGCGCCCACGGATAGCACAACGAGATGCATGTATGTGCTGAGATGTCTTCACAGGCCCGTTTAGTGCTCCAACTTTTTGCCTACCAAGGAATCGAAAATCCCTCTGCATGATGAAAACAGGAAAGCCGCGAAGAACCTCTCAAGCTAAATCATTGCTGAGATAAAACTCGTTGCGCAACCCGGGGGCAGACTCACTTCGTAGGGCATTTACCAGTAACACCCTTGCTCTGACGAAAAGATATGCGGCAGAAACTCTGCCTCCTTCTTCCTCTTCATCGCCCTTCCCAGGCGGCTTGAGTGGGATAAGACGAAAAGATTTGTGCCTGAAGAAACGCAGATTGATCTGGCAAACAACACCTGGTTCTGGTAAAGTGTGAAAAGGCGATTGCTTTACACTGCATCGAGAGAGCAGATATACTGTGAGAAAGTCATACGCTTGGCCCTTCCCAGGAAAGGGGTGATCGTTATGGCAAAACAAGACGTCCCGTGAGAAGGGTAGTGAGATGAGCAAGCTTCTCTTTGTTCCGACAAAAACATCTCGTCGCTTGTGCGCTGGTATGCGCGAGCGCTGCTGCATTTGTTTATCAGCTGCTCATACAGGGAGAATCGATTGTCCAGATCAACAAGACGCAAAGCGTGATCACAAAGGTCGCCGAAGTGGCACAGAGGAAGAGGTTTTCCTATGCCTGAGTCATCTTTGCTGGTGACCAAGTTCACCATCCCACCTCTTCGTTCCACGCTGTTACCACGCGAGCACCTGTTCACGGTCCTCAATCAGAGCCGCTCGTATCCCTTGACGCTACTCTCGGCCTCAGCTGGTTACGGCAAAACAACCCTGCTCTCAGCCTGGGCGAGCCAGAGATCTGGTCAGGTCGCCTGGCTTGCACTCGATGAGCAAGACAACGATCCAGCACGCTTCTGGGCATATGTGATTGCCGCACTCAGGAAAGCTGGCTCTCCAGCAGGAGAGGCGACGCTCGCGATGTCGCACTTCCCACAACCGGCGCACCTTTCCAGTGCTCTGACTTTGCTCATCAATGAACTCTCCACGCTTGGGCAGGAAACGATCCTGATTCTGGATGACTACCATCTCATCAAGGAACCGACTATTCACGAGTCCCTTCAGTTCTTGCTCGATCATCTTCCCGCTTGCCTGCACCTGCTGCTTGCCACTCGTGGTGATCCTCCGCTGGCGCTTGCTCGTCTGAGGGCACGAGGACAGATGGTCGAGATTCGCGACACTGATCTGCGCTTGGACAGCGCAGAGGCGGCCAGTTTTCTGACCCAGGTGATGGTTCTCTCGCTCTCAGAAGAAGAGATCCGTCTCCTGGAGACGCGCACCGAGGGATGGGTTGCTGGACTCCAACTCGCGGCCCTTTCCCTGCGGAGACACGCTGACGTGTCGGCCTTTCTCCAGGCATTTAGCGGCAGCCAGCGTTTTATTCTGGACTATGTGCAGGAGGAAATTCTAGGACCGCTGCCTGAGTCGTACCAACGTTTCCTGCTCTACACATCGGTGCTTGAGCGGATGAATGCCGAAGTTTGCCAGGCACTCTCTGGGGAGCAGGCCAGTCAGCAGATGTTGGAAGCGCTGGAACGGGCCAACCTCTTTCTGGTTCCACTTGATGAGGAGCGGCGCTGGTATCGCTTTCACACCCTTTTCCGCGAGGTACTGCTGGCGCGTTTACAAGCCACCCAGCCGGAGCAGGTGTTGCACCTGCACCGCGAGGCGGCGCTCTGGTATCACCAGCAGGGATGGCCGCACGAGGCGATATCCCACGCGAGGGCCACGCAGGACGCGCTTTTCATGGCAGAGTTGCTGGAGGGCTATGTCGAGCAGTTGTATCTGCAAGGGGAGATCAAAACGCTGCTGGCCTGGATCAAGCTCCTCCCTCAGGAGATCTTGCGCGCGCATCCTCTCCTTGCCACGAGCTACATTTTCGCGTTCAGGATGCTGTCCCCTTTCTCTGATCAGGAGGAAAGAGTGTATCTGCACCAACTCCGAGAAGGTGTGGAGCAGACCGTGCAGAGCGAAGACCAGCGTCGCCTTTCGCTCGCTGAGCAAGAGCGGCTGCGCTATCGGCTTACTCTTCTCGACGGCTGGGAACTGATGACACAGGCGCTCGCTGATGGCAATGGGGAGCAACTGAGCAGGGCTGCTGAGCAGATGGAGCATCTGGAGTTTTCTGACGACACCATGTGGCAGCAGCATCGGCTGGCACCATTCGCCATCGCCTGGCGCATGGCAGGGGATTTTCTCCCGATGGTGACAGCCTTGCAGGAAAGTCGGAAGAGAACCCGAATGGCGCAAAATCGCTATCAGGAGGCCCAAATCCTCTGGGGATTGATTGCCGCACTGATTGCCTTGGGACGCCTCTCACAAGCACACGACCATAATCAGGAACTCCAACAGTTGGTCAACCGTCTGGGAGGACCCCTCCCAGAGGCGGCGTATCCCAACCTGTTCCAGGCTCAGCTTGCGTACGCGTGGAATCGACTGGAAGAGGCAAAAAGCGCTGCGCACAAAGCGATTGAGCAGACAGCACCGTTGCAGTACCTCGACATTCTCATAGGGGCCTCTGAGGTGCTGATCTCTCTCTATCTTGCTCAAGACGATCAGGCTTCCGCTGAACAAGTGGTACGCGAGATGGAACGGATGCATCACGCTGCCGAGATCGCGCTCATTCGCCCCTGGCTCGAAAGTTTCCGGGTCCATCTCTGGCTCGCCCAGGGCGACCTGACGCGAGCCGCGAACTGGGCCGAACACACCTCCTCTCGCCAGGAATCCCTCATCTACAGCCGTGAAAGCGCCTCTCTGGCGCTGGTACGCGTCTATCTAGCGCAGCAGAGATATCCACAGGCTTTGCATCTGCTCACAGATCTCCTGGAGAGCGCCGAGCAGGTTGCCAGAAGAGGGAGTGTGATCTCCATCCTGGCGCTACAGGTCGTGGCTCTCCAGGGGTTAGGTGCCACACAAGGGGCGCTGCGCGTTCTCCATCGACTGCTCACATTGACCGAGCCTGAAGGGTACGTGCGCGTCTTTCTCGATGCTGGCCAGCCGATGCACCAGGCTCTTCAGGCATGGCTCACGACAAAGCACATGCGCGCCGCCATCTTCCCTGCCCCACCGGCACTTGTTTCCTATGTTTCTACTGTGCTCGCCTCCTTTGCCAGCGAGCAGCACCAGATCGTTCAGCAGGAAATCATCCTCCCTGGCTCAAAAGCTCTACCACGCCCCTCCTCTCAAACTGCCCAACAGCTCCTTGAGCCGCTCACGCCACGGGAGCTGGAGGTCTTGCACCTGCTTGCCGCGGGTGCTTCCAACCAGGAGATTGCCAACCAGCTGGTGGTTTCGCTCGCCACTGCCAAGAAACATGTCGCCGGTATTCTCAGCAAGCTCGGGGCAGAGAATAGGACGCAGGCCATTGCCTATGCACGTGCGCTCTCCTTACTCTGAGCTCGTGATTGTGCGTCAGCGCTAGCCCTACATTGCCTGGATCGCTCCGATCCAGGCATCAAGCAGGTATCCTTTTGGCTATTCTGGGCGCTTCTCTGCGCGCTGCTTCTCTCCACACAAGAGAGTATCCTTCTCCTATCCTTTTGGCTACTGTGTTCCACCTATCGAGAGAGTATGCTTCTTCGTAGACGACAAGAGATGGACACGATAGAGAACTCTTCTCAGAAGAGTTCACAAAAGGATAGTAACACATGCACACGAAAACGACCAGCAACAATCAAGCGACTACTCCCGTGCGGGAGCACTACACAACTGGCATCGTCACCTCGCAAGATGGCACCAGCATCGGCTACCGCCAATACGGTCACGGTCCGAGCATTGTCCTCGTACAAGGAGGCATGGGGTCAGCCCATAACTTCCATCAGCTTGCAGGAACCCTGGCTGATACTTTCACTGTCTATGTGCCAGACCGGCGTGGCCGCGGTCTCAGCAGCCCACATAGCAACGATTACAGCATCCAGAAGGATGTTGAAGATCTCGATGCCCTCTTGATGAAAACAGACGCCCGCCAGGTCTTTGGGCTGAGCACCGGAGGCCTGATCGTGCTCCGCTCGGCACTTGTCCTCCCCACCATTCACAAGCTTGCTATCTACGAACCAGCGCTCTCTGTCAACGGCTCTACTCCCCTTGACTGGGTGAAGCGCTATGACAAAGAGATGGCCCAGGGCAACGTGGCAGCAGCGCTCATCACGGGCATGCTCGGCCCGAAGATGGGGCCACCGATTATGCAATACATCCCCCGTCTGCTGCTCGAATTCCTAACAAAAATGATGTTGGCGCGGGAGGACAAGAACGGCAGCGGCGAGTACCTATCGATGAGGACGCTCGCTCCGACCCTTCACCACGATGGACAGGTGCTCTTCGAGATGAGTGAAACGCTGGAAAACTTCCACACTGTGCAGGCCAAGGTACTCTTGCTCGGCGGCTCCAAGAGTGCGGCGTTCCAGAAAGCGAGCCTTGACGCCCTGGAGAAGGTCTTACCTCATGTGACACGTGTTGAGTTCCCTGGACTCGATCATGGCTCTGTCTGGAATTACGATAAACAAAGGAACCCAGGCGGCAAACCGGAACTGGTGGCACAAGAACTGCGCCGTTTTTTTGCCGAACCATAACATGCTTCATATGCGTATGACAAGCGATAGAAAGAAAAGACGACAGGCCAAAAATTCGAGATGGTCTGAGAGGCTCGCGTACAGCCCTATTTCACTGGTCAAGCATATGGATAGAGTCGAGCAGAGTTAGGAAAGAACGTATGGATACCATCACTTCACCATCTTCATCATCGTCGGGACAGCCAGTGCCTCGCTGTCCTATGTTCTTTGCGAAGCAGTTCCAAGACTTGCTCGATCAACGGAACTGGACGATCACTTTCCAGGGCCAAGGGAAGCAGTTCGCGTGTTAACTACAAATACTCTCTCCACCCACACTCACGAAATTTGCATTTCTGCCGTATTTCGTCCAAGTGCTCATAGAGGGTATTGTCGCGGTCCCCGTAACGAGCAAACGCGGATGCTGAAACCTGGATTTGGTCAGCAATGGCTGCCAGTACCCTGCACGCAATCCCCGCTAAATCTTTCAATGGTCGTCCCGGAAAGCGTAATACGGCGAGCTGAACCGCAAATCCCAGGCGATTATAAAGTCGCCTCCTTTGCTTAATGAGATTGGGATCTTGCTGCGTAAAGGTGTTGTAGCGAACAATCTCTCGATCCGGAAGGTCAGCCGGGATTTGGGTCAGGGTATGACGCTGTTCAGGAGTTAAGTAGGGTGGTGTTTTGGAAGTGAAAGGCACGTTCTTCTCCACATACACATAATCAATGCTCTTTTCTTATCATGTGTATGTGAATAGTGTCAATGAAACCGCCACGAACGGGACCGGAAGGCTATCGGCTGCCTTAGTGAGAAAGAGATTCTGGCCCATTCTTGCTCTACCAAGCCTTAGCGGGGAAATATGTACGAAAAATGTTACGATCCCAAGTAGGAGAAAAGAGCAGCAAAGACTGCATGGAAAAGAAAGCAAATAGAATGAGAAGTGCTTGGAGAAAGAGGGAAGAGCTCCATGTGCATGTTCGCTCTCCTGCCTCTGAGGTGGAGCAAGGCTAATCATGGTAAGGTGTCGTGCCTACGAGCTTCAGCACTTTTATTTCATCAAGCTCTCCCCATTTTGCCTCTAGTACTCTATTGCCGTTGTAGAGTCTGACGCTCTTCTGGATATTGCCCCCCAAGGATCGCCGATCATCTGGCAGACACAAGCATGAGAGAACGTTCTGGGTATGGGCTTCTCATGAGCGATGGCTGCATGCTCCTAAGTGGCACTTGGACTTCGCAACTGCTGAAGCTCACTCTCTTGTTGCTGCCGATGAGCTCCCCAAACGTGCAACGGTTGCGCATTTGGGGACAAGTGGACAAGCGCCTAGCCGCGATCTGGGCCAGTGTCAGCAGGAAGCCATAGGAACGCTTGCCCTTCTTCGCAGCAATGAAGGTGCTCATCACCCATTGCTGCCTGAGAGGCGATTCATCCGCTCGTGATGTCCCCCTCTCAGGCAACTTTTCTCTGCGTCTCCCCATGCACAAGGAGGCTCCACTCCTGCTACCTGTGCAGCTCTCGTCCTTTCCTCAAACTCCCACCTCCCCCTTGCTTGCCACTGGTAGCTCTATTTCGAGCAAGCCTGCTAGCTTCTCCGTCAAGCTCTTCATCTCCTCTAGTTATATCGGGACCCCATTTTCTACGAGGTGAGGGCCCAAGCAGTCATAGAGCGCTTGGAACAAGTCAGCGTGACACCGTAGTATCGTCCGTATGAGCCACTTGGCAGAAGAGGATGAACGCTCTGAGCGCGCGCTCACGCACCCTTCATCGTCTCTGCAGATGGTTGTAGAGCCCTGCGAGGAGGGAAGAAGAGAACGGCTCTGGCAGGTGGGTACGAGCAACAAAGCGTGACTGTCTCCGCCATCACAGCGGCTCTCTCTCCTGGCGACTACAAGGTTCGAGGAGGCTTCTCGCAGAGGCCTCCTACATATTTTGTGGCAGTGCAAAAGCTGAGTATCATAAACGTTCCAGCCTGTTGAAAAACTCCTTGCTGAGCTTACAAGTGGGCCCATGAGTTTGACGGAGCGAGGGTTCCGCCAAGTGGAGAGAAGGGTATAAGGATAAAAAGTGCATGTGAACGGGAAAAGAGGAGAAGCTGAGATTGACAAAGGAGGAAAAAGGCGATGCAATGGGGACGAGGAGGAGCAAGAACTATGATGGGTTTCAAAGAGCGGGCCTTTGCCCCTTTAGTCGCAGTTTCCCTGGAGGAGTTGGTTCCTCAGGATCATTTTTACCGGCATCTGCAAAAAGCCCTGGATCTCTCGTTTGTCTACGATCACGTTCGCGGGCATTACGCTGTGGCTGGGCGACCGTCCATCGATCCGGTGGTCTTTTTCAAGCTCCAGTTGGTGATGTTCTTTGAAGATATTCGCTCGGAACGCCTCCTCATGCGCCAGGTGGCAGATCGGTTGAGCGTACGCTGGTATGTGGGCTATGAACTGGATGAGCCACTGCCGGATCATTCCACGCTCAGCAAGATTCGCACTCGTTACGGCTTGGAGATATTTCGCCGCTTTTTTGAGACCATTGTGGAACAATGTCGCCAGGCAAAATGAGTCTGGGGCAAGGAACTCTCCTTTGACGCCACACAAGTTGAAGCCAATGCTGATCTCGATTCATTGGCCCTACGTTTTGCCGTGGAAGCTCGCGAAGCCATCCGAGAACACCTCGCTGCTCTGTTTGCCTCTGAACCAGCAACACCTGAGCAGACCGAGGAAACGCATGGGGGCTCCGCTGTTCTCGAACCCATCTCACCGGAGGAAGCCTCTCCAGGACCCTTTCCGCTCCCCACATCCCTTTCCCAGACGCGGCGTGATGACCTTGCTGCCGACAATGCGGCTCGACATGACTGGATCGCTGAGGAGGGTCGGCCCCAACGCGAAGTCCATGGCACCTATCAACGGACAGCGGACCTGCGGATCAGCACGACTGATCCCGACGCCACGCCCATGCGTCTCAAAGGAGGAGGGACACACCTGGGCTACCATACACATTACGTTGTGGACGGAGGGAGAAGTCGGATCATTCTGTCGGTGCTGGTGGTGCCAGGGGAGGTCAATGACAATCAACCCATTCTCGATCTGATCTGGCGGATCCTCTTTCGCTGGCGTCTCCGACCCAGGCAGGTGACAGGTGACATGATGTACGGAACCATCGAGATCATCAAAGCCCTAGAAGATGCCCACATCCGTGCGTACATTCCTGTTGCCGAGAGAGGGCAACGCGCTGGCTATTACGGATTAGCGCAATTCACGTATGATGCATTCCATGATCAGTTTACCTGCCCTCAAGGACACATCTTGCGGCCTGCGTACCGCTTGGAGGGGTCACAGGAAGTACAATATCGCGCAGACGCTGCCATCTGTAACGCTTGTCCAGTGAAGAGTGCGTGTACCGAAAGCAACCGTGGTCGGCATGTCCATCATCCTTTTTTGGCCGACTACCTTGACCGTGTGAAAGCCTACGAAGCCATCTTTGCGTATCAAAAAGCGCTCAACAAGCGCAAAGTCTGGGTCGAACCACTCTTTGGAGAGGGCAAGCAGTGGCATGGGATGCGGCGTTTTCGTTTGCGACGACTCTGGCGGGTCAACTGTGAGGCGCTCGTCATTGCCTCTGGTCAGAACCTCAAACGCTTGCTCCAGAAACGAGGTTGGGGGCGACGTCCGTTTCCCTCCGAAGCCGTGGCCATGGCTCTTCCCCTGGCTTCGCCGATAGAGAAACCTCCCACCAACAGAAGCAAGACCATCCATAGGCGCAAGGTCGCCGTGGCAGAAATGATCTCTCTTGGCCTCAACAACAGGCAATCTTACGCATATATCCTTTGTTTTTCTTTGAATAGTCATTTTATGACTATTTTCCTTATTTTATCCTCATCTCCTATTTCACTTTTGCCTTCGTTTTTGCTCTACCAAATTGAGATGGGGAATTTTTTAGCTCATCCTTTCTCATAAACTCTGCTGGGCATTTTTCAACAGGCTGGTTCGTTTCTTGTGACGTGTAACGGAGTTCACCTGAGTCGTCATGGAAGTGCCTATTTCTTGGGAGTTCCCTCCTGGCATGGACGTAGGTCCTTTGCATCCTCTTGTTGATGCCTCCCGCTCTCTTTGGTGCCATCCGGCCACAGCAGAGTACGAGGTGTCGTTCCCTCCAAGCTTGAGGGGTCACAGGTTGTTGAGGTTAATCTCTACCCGCTGCTCGATCGGAGTTCCATTCACCTGCCCTCCAACATTGATCCATGCTGCTTGCATTTCTGCCTTGTAGATGCGAAGCGGGGAATTCCCCCTCACGATCTCTATCGCAGGAGGCTGTTCACCTGCTCGCCCAAAAACGGCGAGCAGCCCAGACGCTATCTCGTCTGGATCTGACAATTCCTGTGCGATGGCTTGGATATAGACCCCCTTTCCAGTTCCTTCAGAAACGGTTGAATCATAGAGAACCGCTGCGATCTGCCTGTGTTCTCTGATATTCTGGGAGTGATGGGCTTGCCGCGCTGATATCCAGTAAAAATGGTGATTGCGATCAAAAGCCACATAGACCGGAGAGCACCAGGGAAGACCGCTTTGTGAGGTAGTCGCAAGACTTGCATAACAAATATGAGCAAGAATGTTTTTTGCAATCCTTGTGTTCATGAGCTATCTCCTCTCCTCCAGTTCGGGTGGCTTACGGAAGACATAGGGAGCTATCTCACCGTCCTGACTCTCGGGGGCAGCAACCGCAAAACCATACTTACGCAAGAGCCACCGGTCAATATGGAGTCCGACCAGGAACCGAGCAAAGGGAGAAAGGGGGCAAAAATAGCCGTACTGCCCCTGAAGATGACACCCCAACCGTTGTTTGTTCGCCTCATGTGAAATCCCAAAATCAATCCGCTCAAAGCAGTGGTCAATGGCGTAGCGAATAATTTCATACTCGGCATACCGATGAGCAGGAATGTTGCCAATAAGCGCATAATCCACGCCGCTATGACCGGCCTCAAGCGTGGAGGCATGCTCAAAGGTGAGAATGAAAGTGAGGAGGTGTCCCAGTCGTTGCACGAGAAATACTCGACAGCCTGGCAGCGTCAGCGCTTGACTGAAATAGGCTGGGGGAAGAAGGAGTTGATCAGGGTCCTGATGCTTCCAATACGACTGGAGCCAGAGCCGATGCAAATCGGGAAGAAAGGCACGGGCCTCCGATCCTGGGAGGACCTGCAAGGTGCATTGGGCCTGTTGCACCCGGCGTAGGTCTCGGTGAACCAACTCACGGTAACGAGCACGCAACGCCGTGAGGTAGTCGTCAAAGGTTACCCACCGAAGGTGGAGCCATGCCTGTTGAAACAACGGCTGGCGATGGAAGCCGAGTGTCCTACAGGTGTCCTCAAGCGCCTTGAAAGTGGTCAAGGTTTCTTTGTTCACATCGCGCAACACCATCATTGCGGCATGTTGGGTGCTTGCTTCCCGGATCATGCCATCGATCAAGGTGCGAAGAATCTCCTGATCGGAGCAAGACTGGGAGAAGCCGAAAGGGAAGCCTATCGTGAGCGGTGAGGCCCCGATAAAGACCCTGGGATGAAGCAGGGGAAAGAGGGGAAAACGAGTGAGATAGCCAAAACTCGTTCCCACGACCTGACCGTCCTTGCGGGCCACAAAATAGCGGAAGGTACAATCGAGCTCACAACGGGCAAGAGCCTGGAGGTAGTCAGCAGAAAAGGCGCTCTCCGCTGCACAACAGCCATTCCAGTCCCTTGCCTCAATCTGGTCCAGTTGCTCGAAAACCTGAATCGTTAGTGCTGAGAGATTTTTCTGGGTATCCATGAGCAGCCACCTTTGAGAGATTGAGGGCTATATCCCATAAGCAGATGCAGCACATTCAATCAGCGTGTTGCCTGATGTTAAGCGATGAGCTGAGCAAATTTCCAGATCTGCGCAGTGAGCAAGGTTCGCATAGGTTTCCAAGGATCGTATCTGACCTCCGAGTAAAACCAGGGTGAGTAATTCCTCAGCCGTCACCGGGCGAGGAATGGGCTCCTGACCGCTGAGTGGTTCCAGGATGAGCACACGTCCTTGTGGTCCAATGGCTTGTGCACAACGACGAAGGATCTCAATCGCGGGTGCATCATCCCAGTTGAAGAGCACACAAGAGAGGAGATAGATATCCTTCCCAGGAGGAAGCGGCTCGAAAAAGCTCTTTCCAACGATGCTACAGCGCTCTAGCAGTCCTCGATCAGCAAACGTGGCCTGAGCACGGGCCGCTGTTTCAGGCAACTCAATGAGTGTCCCAGAGAGTGCAGGATACGCGTGAAGAAGTGCAGCAAGCACGCTTCCCATTCCTCCGCCGACATCAACGATATGACCTACCCTTGTCCAATCATAGCTCTTGACCAGGGCATCGGCATCCTCTGTCGAAAGCCTGATCATCAAGGGATGAAACCAGGCGCTCAGGCTGGCGTTGGTGCTTAATGCTTCCCAGAACGTACATCCGTAGATGGCTCGATAGGCAGCTTGACCTGTGCGAATCGAGTCGAGGAGCCCTATCCATACTCGATCCATGTTTCCTCCCACCCCTTCTTGGTCGAGCTGTTCTCGCAGATGCTGGGGATGATCATCGAGAAGCATACGGGCTGCATGGGTCAGTTCAAAGTGTTCTGGGGCTCGTTCGGTAAAGATCCCAGAGGCGCTCAGATAGCGCAAGAGCATACCAAGTGCACCTGGATGCACCTGCGCTCGGCTGGCAAGATCCTCCAAGTGGGTCACGCCCCCAGCGATGAAATCGGCCAGGCGTAATGTCGCGGCGACTCGGATGGCCCAGGGCAGAGCGAGTTCTGCTTGCTGATCCAGGCTCAATCCTCTTTGTTTCTTGGTGCTCATCGTTGCACCTCCTTCCTGCCCTGTTTCAATGAATACTGCTGCTCTCGTTGGAGGCCGAGATCACCACTGATGACCAGCAAGAGCGAGCCAATCTTCATCAAACGCATCGACCCGTTGAACCAGAGGTCGCCAATGGCTACGATCATCGCCGTGCCCAGCGTGGATCAGAGGCAGAGGCCATCCCAACGTCCATCTTTGTGAGCACCAATGAAAGCAGAGAGATGTTGCAGACAGAAGCGATTCTTGCCAGAAGCGTAAGCAAGAGCTGTGAAAAACCATAGGAGCATTTTAGGAGTGTTGTTCCAAGCATTTCACAAAAGATGGAGAGGACGAGAGAGATGTGGGTCATCGTGGCACCTCGATTTAAAACTGATAGTCTTCTTTGACGGCAGTAAGGGCTTGAAGGAAGCCCTCGATCTGCTCTGAAGTATGCATCCTATTGGGCAGAATCCGAATCATGGCGTGGTTGAACCGGACAGCAGGATAATGGAAAACAGTCACCAGATAGCCCCGCTCGAACAATCCACGACGAACCGGTTCTACTTTCTCATCATCGCCCACCAGGATCGAAGTGATGTAGGTCGGAGTTGGGTTGAGGCGACAGCCTATGGCTTCAAGCCGACGGCGAAAGAGCGCGACTTGCTCTAAGTAGCCGTCCACAAGAGCAGGCTGTTCGACGAGTTTGTGCATAATGAAATGAATCGTGCTAGCGGTTGGGGGTTGGATAGCAGCAGTAAAGATCGATGTTCCTGAGAGAAATTCAAAGGCGCGTATGGCATCAGCGGGACCTGCAATGATCCCTCCTTCCAGGCCAACGGACTTGGAAAAGGAGGTCATCACAAAGGTTGCTCGCCCAAGGTGGGCAAACTCCTGAGCAAAGGGTCGCTGCGATGGTCCATAGATCAAAAAACCGTTGGCATCATCCACAAAGCTGACAGCCCCATAGCGCTCACAGACATCTAAGAGCGTACCAATAGGGGCGACTCCTCCATCCGTGGAATAAACGCTCTCGAAAACGACGACGATTTTTGCCCCCTGCAGCCTGGCGAGCATCTGTTCTAAATGGATCGGGTCGTTATGGGGAAAATACTCATGCTGTGGAAATCCCTCAACACCTTTGCGTAGGCTCCAGTGGCAATCCCGATCTAAGAGGAACACGGTTTCCCGATTATCGAGCCCACAGAGCTTTTTTGTTCCGAAACGTGTTCCCATGGCGTGCAGAAAACCCAGGTTCGCTAAGCAGCCAGAAGCAAACGATAATGCTCGTTCTTTGCCAGTAAGGTGGCAGTAGAATTCTTCGACTTGCTGATGGGCCTGGCTTACCCCTTGAGCTAAGCGCGAACCCGCTGTCACGATCCCATATCGACGGGTGGCTTCCAGGAAATGCTCCAGGATTTCTTCATCCTGTTGGAATCCAAGAAAACTGATCCCAGCCAGATTCACCAGCTCCTTCTGCCCTAAGCGGATGGTATCATAGGCGGGACTTTCTAGAAAAGAAGGCTCATGCCAAAGGCTCCGCTCTTGGAGCGCCGCAACAAACGAGGTGAACCCCCATGCGTCCAGAAGAGACTGTTGGTGTACCATTCGTTCTCCTTCTCTAGCCTCTCGGCTTCATTTCCTCCTCTCCCAGTGAAAAGGAGTGTTGAAGCATCCTTGTGCAACTCGTTCCTTCTTGTTTCTCAGAAACCAGAGATGATGGTGAGAAGCCTCCCTTCCCTTCTGCAGTTCAGCCTCACCAGAACTGACCACGGACGGACAATGACGAAGGAAAGATCCCTTCGTTGCTGCCACGAGACTGTCTCCTGGATGGTGACAAGGGAGGGACGGGGACTCGAATGGCGTCATCCTCATGAGCCTTGGCAGGAAGCAGAGAAAAAGACGCCACGCCTCCCGCTTTTTCCGCAAACGTCGTTTTACGGGGAAGTGTCAATATCGACCCTTTTTTTGGAACGGATTGCAGCGTCGCAAAACCGTTCGTTTCTTGGGATCAAGGGCAAGAGCGCCTGGCAACGATCCTCTCTCGCACTCACGTTGAGCTTCTGCCTGGCACGAAGGTAACGCCTGATCCGCAGCTGACCTTACGTCCACGTGATGAGATCTGGGTGACGATGAACAGCACACAGGCATGAAAAAGGGGAAACAATGAGATGAGACCTTATAGCCCAGACACGCATGGCTTCGTCGCATGGTATCGTTCTGCGTGAGTGAATTTCTTGCCCTCTGCCTGACGGCGTTAGTGTGCGTACCAGTTCCACCTTCTCCTGCCTACTTAGTGGGAAAGCCTCCCTCGGAATTTTTTTAGCATCTCGTTTTGGACCGTCATTGAAGGCATCGAGCAGAGAGGATCGCGGATGAAGGACAATGAGAGACAACGGTGATAAAGAGGCGCTGGTGGATGGATATGTACCAACTTTTCGGAGGCGGTTGAGCAGTTTTTCTGCCCTGCTAGACTAATAGTAGACATTCTGTCCACATTCTGAATGAGCAAGTTCGTCAGTATTTCCTAGAGTCAAAGTTTGTTGGCGAGAAGGCTTCTCGCTTTCCTATGAGAAACAGAAGATCTGTTTCTTAGAAAATCCTTTTTTGGAGGAGACATGAACGCACCTGAACCAAGTCCCGCTTCAACATATGGTGGAGAAGTAGAGACCTTAGCAGTAGAGGGCAATACGGGACGCTTGTTTCCAGTCGCTTCTCTTTTACAACAACACGCCCAAAAAATACTCAGCCAGGATAGGGAACTCTCTCTGCAGCGCGTAGTTCTTGATTATGATGAAGCGGAACATATTCTTGAGTTTCGAGGGGTAGTTGCTCACCACCTTCCTCAACTCATTTCAACGTATCGCCGTTCCCTTGTGCTTGTCCAAGAGCTTTTGCGTCAACACTCACCCGCAAGCTTGCTTTCTTCCTCCTTTCACCCCTTAGAAGACCCCTCTTTTGCCTATCAGTATGTCGTTCCTAAACCCCTCTATGAGCTCTTTCAGGGGCCTTTGCAGGTAGGATCGCATGTCCCCTTCTCTGCCCTCTCAAAGATCTATCCCACAAACCCTGAAAGAGGGCGCGGCTGGTCACTTGAGCTCGGAGCGATGGCTGCTTCGATCCAACCCTGGAACTCCTTGCCTCTTGAAGGGGCAGCCTCACAGATAGCCTTGCTTCAGGCAATGGGATGGATGTTCAATTTATTGACAGCCAACTCACCTTTTTTGCAAGGAACGCTCTCAGACAAACGCGATTACCGCCTGGAAGTCTGGGGAGATCACGGCTTGCTCGCAAGCAGCCGTTACCTTACAGATTTGGCATTGACCAAGAATCTGCCCACACGCCCTGCAGGTTTAACTGACTACTATCGGTACGTGTTGCGTCAGCAAAGACCGCTTGTTCTACCACTGCGCAAAGAAACAGGCTCTGCCAACGAATATAAATACACCTTTTTAGGTATTATTCAGCCAAACGATACCCGGGAATTCAACGCGCTGACCTATTTACAAATGGATCAGGTAAGAGCTGTCGACATAGAGACTGGAGAAGAGCAGGACGTTCATCCCAGCGTAGCTCATCTTTTTAATGGTTTTGATTTTCTCTACTATCCCCGCTATGGAGCGAGAATCCGTTTGCATCTTCCTGAGGCTGATCAGCTTGACCCCAAACTCTTTGCACAAGCCGTTGAAAGCCGCAATGAGCCATTGTTTCATTCCTTGCTGCGGCAAGCAAAGGTGCAAACAGGCTTTCTCTGTGCAGAAGGACGTATTCCAGCTACTGTTTTACCTACACACACACATCCAGGGTGGGAGCGATTCAGTATTCCTTTTGTGCTCCAAACGGCTCTGGTGCGTAGCCAGCGGGAAGTCTTCACCTTTCTTGCGTCAACCCCACTCACCTGGTATGACTTAGCACATCGGCTCCCTTCACTCTGCAATGAGCGCACACAGGGGTTTTCTGCCTGTGTGAAAGGAATCAATGCCACGGAGCTGGCGCGTCAGATCTGGGCACTTGCTCGACAACGGTTGACTGAGGAAGAGGTGGCCTGTGTCAACAACGAGATTGAGGAAATCCTGGACACGCGCATGGCTCCTGCCGAGGAACAGGTTGCACTCTTTGAAACGCTTTCTCAGCGCACGACGAAACCATCAGCCTTCCGACAAGTGATAGAGCACTGTTCTATGATATAGAAAGATAGGATCTTTCGGCAGAGAGCGAGGAGCGTTGGCCCTTCTGAGCTTAGGAGAAAGGAGCCATTCCCATGCCTTCTTTCTCCCGGAGACAGGTTTGTGAGCTTCTTGCACATCGTTTGCCCAGCTATCCAGAAGCCACGAGCATGATCTCTTAGGGCTTCAGGCACGTGGCTCATGTATCCCCACATGAAGCTCATTCAAGCCACGTAGGCCGAGATTGGCCCGCCAGGAAATGGGCTGTGGTTCTAATTGGAGAGATGGCATGCGCCGTAGCACAGACTCAAAGGCAATCTGTCCTTCAAGCCGGGCCAGAGGAGCACCGAAACAAAAGTGGTTCCCCCAAGCAAAGGCCACGTGACGATTATCTTGACGACCAAGGTCGAGCAGATCTGGATCTGGAAAACGTTGCGGATCACGATTGGCAGCCCCCATCACTGCAATAACAGCCTCGCGCTTGCTGATGTGCTTGCCACCCAGTTTCACGTCTTGAGGAGCGAGGCGTGCCGTATGCTGGCTGGGACTTTCGAAGCGTAACAGTTCCTCAATGGCAGAGGGAAGGAGAGAGGGGTCTTGCCTCAATCTCTCTAACTGGTCGGGATGACGAAGCAAGGTCAACATTCCATTGCCAATCAAATTTGTTGTTGTTTCTTGCCCACCAACCATCGTGACAATAGTATTGGCAATCACCTCTTCTTCTGTCAGACGATCACCGTTGATCTCTGTTATAAGTAAGGCATTGAGCAGTCCTTCTCGCGCATGGGCCCGTTGTTGCTTCACCGCTGCCTGAAAGTAGGCAATCATCTCTTCAAGACTTTTGAGCGCCCGGGAGGCAAAATCGGGATTGTGTTGAAAATTTCCCAGGACCTGGGCGAAATCAGCAGACCAAGCGGTGAGTTGAGGCCAATCCTCAGTTGGAACTCCCAACATTTCTGCTGTAACGATGGCCGGAAGTGGGTAGGCCAGATCTTTAATGACCTCCATGTGCCTTTTCTGCAAAACAGCATCCAGTAGGGTATTGGTGATATCCTGGATATGAGCGCGTAGCACTTCAATACGTCGAGGGGTAAAGGCTCGGGAAGCCAGGGTCCGTACACGGCTATGAGCCGGAGGATCGAGAAAGAGCATTTGATGGACCATCACCTGGGCTAATGGGGCAAGCTTGTGAAGCCCTAAGGCGCTCAACTGCTGCGATGTCGGGGTACGATTGGCAGAAAAGCGTTGGAAAACTGTCACTACATCTGCATAGCGCGTGACCACCCAGGCATGTAAATAGGGGTCCCAATGCACCGGATCAGTACTGCGGAGTTGATGATAGAGAGGATAAGGATTAGCAAGCACTTCGGGATCGAGAAGATGATAGAGACTGAGCGTTTCATTTTTCTCCTGACCTGACGATAAGGCCATGATATATTTCCTCCAGACTTCTACGATGAATATTGCCAACATTACATTCGTTTAGAGCACAAGCAGCTCTGGCTGCTTGTGCCCTCAGCGAGACACTCAAAGAAGTACATCACTTTTTTCTCAGTATACCAACGAGGGAATGAAGCTGTGCACGGCTCTGGTTACTATGCGATTCTGCCATCAAGAAGCATAGATATCCTGGTATCCTCAAGAAAATACTTCCCAGGTCGATCTCTACTAGAAGCACAGGAAATTGTACTTCTCTCTCCAGAGGGGGAGGAGAGAAGAGAATGAAGAGAAGAGGTGGACGATGTATATTTCTACAGAAGGCTTCCAGATGCGAGAGCATCAGCAATGGCCAGCGATGAACCTGAAGAAGGTTGAAGAGGTCCTGAACTGCCATCCAGACATCCAGAAGGCGGTAGTTATAGTACAGGAGGATACCTTTGGACAAGAGCATCTCGTCGCATATCTGGTTCCAGATCCTTCACGCTCAGGCCCTCTTGGCCAGTTATTGCGCCTGGAATGCGCAGGGACTCTTGCCCAACATCCCACGTATGAACTCCCCAATGGTATGACGGTCTTTCAGAAAGGCCGCAATGAAACAGAGTTAATTTATCGAGAGATATTTGAGGACAAGCACTATCTGAGCGAAAGCATGTGTTTGCCTGAGCACGCTTGCGTGTTTGATGTAGGAGCAAATATCGGTCTTTTCTCTCTGTTCATCCATCAACTTTGCCCTACAGCTTGCATTTACGCTTTTGAGCCGATTCCTTCTGTTTTTGAGTTGTTACAACTCAACATGTCACTCTATGCAGTCCAAGCTCATCCTTTTGCCTGCGGTCTCTCTAAGGAGGACAAGAGTGAACTCTTCACGTATTATCCACACTGCTCGCTCCTATCCGGCTTTTTGGCCCAGGATGAGCAAGAGCGCGATGTCGTCAAGACTTTCCTCCTCAATCAACAACAGATCAACGAGAGCAAGCAGATACCTTCCCTTGATGAGCTAGATACATTGCTGAAAGAGCGCTTGATCACTGAGCAGTTTGTTTGCCCTGTAAAAACAGTTTCGTCGATCATGCGCGAGCAGGAGATAGAACAGATTGACCTTTTGAAAATCGATGTGGAAAAAAGCGAACTGGATGTACTGCTGGGGATAGAAGAGCACGATTGGCTCAGGATTGGACAAATTGTTATCGAAGTGCATGACCTTGATGATCGTGTAGCACAGATTCAAGCTCTCCTCCAAAGGCACGGCTATCGCCTGCATCTCACACAAGATCGTTTCCTCGAAGGAACTGGTCTGCACTATATATCTGCAGTGCAGGAGCGCTATCGCCCTACATCCACTGCCAAGATAGACCTTCATAGGGAGCAGACAGAAGATCGCGGATGGCAGAGTCCAAAAGCACTTTGCGATGCGGTCATGCAATTTTCAACCACGTACTTAGCGCCCTGGGAGCTTCCTTCTGATTTCATCCTCCTGGAACACTTTCCCCTCTTCCCTGATGGCAGGGTTGATACATCAGCGCTGCCTCCCCTTAGAGAGCAGGCATGCTCTTCCAAACGCAGTTACACGCCTGAGACCGATGAGGAGCGTATACTTGCAGACATCTGGACGCAAATCCTCCCTGTGGCTAAAGTGCAACGGCATGACAACTTTTTTCTGCTTGGAGGAGACTCCATCCTCGGTATGCAGGTCGTAGCTCAAGCCAGAGAAAAGGGTATAGACATGAACATCATGCATCTGTTCCAGCACCCCATCCTGACAGAGTTGGCTGCTACTGTTCCCTCCCTTCCTTCCACCACAAAAGAGGAGCGGTAAAAGCGTACATACTGATTGGATTGCTCATAGAAAGGAAAGATCTTAATGGTATCTGAACGGCACCCGGATTTTCATACCTGGGTGATCAGAGCTCGTCCCAATCCTCATGCTCGTCTACGACTCTTCTGTTTTCCCTACTCGGGGAAAGGTGCATCGCTCTTTCATACCTGGTCACAAGAGTTGCCACCAGACATAGAGGTGTGTGCGATAGAGCTTCCAGGCCGAGAAAGTCGGTTCCGAGAACCTCCTTTTACCCAACTTGTGCCTCTTGTCCAGGAATTAGCAGAAGTGCTTCATCCCTATCTTGATGTTCCTTTCGCATTTTTCGGACATTGCGTCGGCAGTCTCATCAGTTTTACCCTTGCTCGCCAGCTACGACGATCTTATCAAGTGACCCCAGCTTTCCTCTTTTTGGCGGCTCATCGTGCCCCTCAATTGCCCAGCAGGCAGATCCCTCTTCATGCACTGCCCGATTCAGAATTTCTGGAAGGTGTTCATTGCTTGAATGGCATAACTGAAGAAACATTCCAGAATAGTATGCTCATGCAACTTGTCCTCCCAAGTCTACGAGCAGATTTTACCCTGGGCGAGACTTATCAGTATGAGGAGGATGAACCCTTTGCCTGCCCCCTGGTTGTCTTTGGTGGTCGAAAGGATCATCTGGTCAGCAATGAAGAGCTTGTAGCCTGGCATATCCAGACACGAAGTGATTTTACCTTTCATCTCCTGGAGGGTGGACACTTTTTTCTCCACGAGAGTCGCCAGGAGTTGCTCAGTGAGATCAGCAAGAAGATCCTGTACTGGAGTGACGGCACACTACGTCCCAACCAGTCTCTCTCCCCTAATACCTCATGGAGATGAAGCGAGCACTATGTGTAAGCAATCGTAGAACTCATTCTAGAGAGGAGAGCACCTATGTGTGCAAAGCGAAACCCAAATACGGCTACTCAGCAGCAGTATCCACAAGCTCGTTGTATTCATCAACTCATCGAACAACAAGTCCGCTGCACACCTCAAGCCTTGGCACTTACCGATGGGCAACAAACAATGAGCTATAGAGAACTTAATGAGCGGGCCAACCAACTTGCCCACTGTTTACAAACCTTAGGGATAAAACCTAACGTTCCTGTAGGAGCCTGCCTGGAGCGTGGGATTGAGCTCATCATAGGGCTGCTTGGTATTCTCAAGGCAGGAGGAGCTTATGTACCGTTCGATCCCACTTCTCCCACCGAACGGCTGGCCTTCATGAGAGAAGATGTGCAAGCCCCAGTACTTGTGACTCAGAGTAAGCTGGCATCTCGTTTTTCTTCACAAGGTACTTCCGTGCTCTGTCTGGATACGGATGCCTGCTGGCTTACCCAGCAGAGCATGGATGACCCATACTCTGGCGCAACAGGAAATGATCTGGCCTATGTGCTTTATACGTCAGGTTCAACCGGGATGCCCAAAGGAGTGCAAATTACACACAGCAATGTCCTCAATCTCGTTTTTTGGCATCAAAACGCCTTTTCGCTTGTCCCATCAGATCGCGCCTCTCAGCAAACGAGCCCGGCCTTTGATGCAGCAGGGTGGGAAATATGGCCATATCTGACCTGTGGAGCCAGTGTCCATGTGATTGCAGAGAGCATACGCAAGCAGCCACTAGCACTTCGCGACTGGTTTCTCGCCAAAAACATCACGATGGCGTTCCTCCCGACACCACTTGCAGAGCAAGTGATAACGCTTGAATGGCCACACTGCACGTCCCTCCGTTTCTTGCTGACAGGGGGAGATACGCTTCATCGGTATCCTCCCGCCTCTCTTCCATTTACTCTGGTCAATAATTATGGACCAACAGAAACGACAGTCGTCGCCACTTCTGGTCCTATTCTGCCGGCGGCACGGAGTGCCTCTCCTCCAACCATAGGACGTCCTATCGCTAATACGCAGATCTACATTTTAGATGAAGAAGGGCAGCAAGTAGCGCCTGGCGTAGTGGGGGAACTCTACATTGGGGGGATGGAGTTGCTCGTGGCTACTTTCATCGACCGGAGCTCACAGCAAAACAGTTTATCGCCAATCCCTTTACGAAGAAGCCTGGGGCTCGTTTGTATAGAACAGGTGATAGGGGCCGTTATCGTGAAAATGGAGAAATAGAGTTTCTTGGGCGCACTGACTTTCAGATCAACCTTCACGGCTATCGGATTGAACCCAATGAGATCGTCACCTTATTAAATGAACAGGCAGGTGTGAAGACAAGTGCCGTCATCGCCCGCGAGGATTCTGTGAGAGGGAAATACCTGGTTGCCTATATCGTACCCGAAGCGGATTCATGCATTTCAGAGAACGCTTTACGAGCGGTCTTAGAGAAACGTTTGCCTCACTACATGATCCCCACCACCTTTGTTCAGCTAGAGACGCTTCCCTTAACGGCTCATGGAAAATTGGATCGAGCCGCCTTTCCTGAGCCTCATTTGCTCAATAGCTTGCACGATAATGCTGCCGAGCAAACTCAAACGCCTCTGGAAGCACAACTTGCAGTGATCGTTACTCAGTTAATGGGGCTAGAGCGGGTGGGAAGGGATGAGAATTTCTTTCTCCTTGGAGGTCATTCCTTGCTAGGAACGCAACTTATAATGCGGATAGCAGCAACCTTTGGCGTGGAGCTCCCATTACGAACGCTGTTCGAGTATCCAACCATACGGCATCTCGCAGCAGAAATAGAGCAGCGTATTCCTGCTGGCGGTCTTCTACCCGAGGAGAAGGAGAAAAGTGCCTTCTCCTCACAACAGTAGCCTCCTCACCAAGAGAAAGGCTTCCTCTGCCCCTGTTTTCTTGGTTCTGCTTGCTTTGGCCATAGGCTTCTCCAGGGTCTGCAGTAAACCTTCATTCAAAGAAATGATGTGTAGGCAACGGGGTAGATGAGAATGACAAAATAGCTAGCACTTAGCTCTGTAAACTTGCTTATGGGGTCTGGCACAAACTTGATACTGCTGGCGAACCCAGATAGACTCTACGCCACCGGACGGAGGAGTTGAAGCAAAGGGGAATGCCTAGTTTGCGCATGGGGAACGCCATCCTGCCAGCGCACGACCCGAACGATATTGAGAGCAGCAGCCGTCGCGACGTGTTGGAGATGGGTCTTTTCTTGACCGATGTAGCGTGATCGTCGCAGCCCCATCACACGGACGCCTTGCGAAATGGTCCCTTCCACTCCGGCACGCTGGGCATACAAGGTTTTGACTTCCTCAGTTGTGGCACGTGCCCTGGCGCGCTGTAAGGCTTGATGTGCTTGTTCTCGGCGCACGGTGATGGTCCGACGCGGGACCCGTGTCGAGTGGGTACACAAGGGGCGACTAGGGCAACTTTGACAATCCTTGGTGGAAAACTTGATTTTGATGACCTCATTGTGGCGGTTGTCGATGGCTGGAGTCCAGCTCATGCTGGCGTGGCCTTCCGGACAAACGGCTTGTTGCGTTTGCCAGTCGATGGCAAACTGCCCTGCTGCGAAGCCTGTCTGTTGGCGGGCTTGCCATTTGACATCAGGATGAGGGGGACCGACGAGATCAATATCGTAATCCTGCTGGCTCTGATGGAACAGTTGGGCATCCACATATCCAGCATCGACAATGTGCTGTTCCGGGAGCAGGCCTTTGTGCCTGAGTCCTTCATGAATGGTTGGGGTGCTGACATCATCGCTGATGGGGGCGGTCGTTGTTTCCACATGCGTGATCAGGTGTGGCTGATCTTTCTCACGGGTTTCTGTCAGATGGACCTTGAAGCCAACCCAACTGGTAGTGCGCTTCTTGCCGTAATGCGCATCCACATCGTAGGGCGAGCTCAGGTAGAGGGTCGCAGGAGGGATATTGTCCGCAGCGCGCCAACAGAGCTTCCCCTCGCTCCACAGATAGTTCTGAGTCCACACGCGCCGCAAGATCTCGACAGCAGGGACTTCTCGCAACCAGGCGGGGGCCTCCGGCTCATAGAGAGCGCTGAGGACATTGGCGCCGTCTTGTCCCACATGCCGTATCCACTCCTGTCGCTCTTCTTCTCCAGAGGGCAATCGCGAGTCTTCCAGACGCACCCCAGAGCAATCCGCCCACTCTGGCTGGCTGTGTTCACGCAGCCACTCTGGAGCCACGATCGCCAAACATTTGAGCGTATGGCGCAGGGTTTCTCCGACGCAGACCAGTCGATTGAGGGCTCGAATCTTGGCCAGGACATGGGTTGAGTCCGTACGCTGTTTCCCACGTGCTTTTAGCCAGCCCCGCTGCTTGAAGAGCGTGAGCATTGCCGTCAACAATTGCTCCTCCCCCTGGCCTGCAATCAAGCGGGCACGAAATTCACTCAACACTGAGGCATCAAAGCCTGAGTCGGAAAGCTCCAACCCGAGGGCATATTTGAGGTAAATGCGACCTCGCACCGCATCAGCGGCTTGTCGATCTGAGAGTCCTTCAGCGAACTGGATGATCGTCACCAGGGCGAAACGCCACGGCGCCTCGGCTGGTTGCCCATCCTTGGGAAAGAGCGCGGCGAAGGACTCATCTTCATAGATGGTCCCCAACTCATCCCGCATGTGTATGGACACGTTCCCTTTCGGGTAGACTGCTCGCGCAATCCGAACCGTTTCTTCGGGGACAGGATTGATTGGCTGTGACTTGAGTGACATCGCTTGTCTCCTTCTAGCTCCTCTTGATCAGTTTTGGCTATCATACCAAAACCTCTCACTGAGTGCTACTTCCCCCAGGCCAGAGAGGTTCGCCAGCAGTATCAAACTTGAGGATGTTCTCCTCTTCTCTCTGTTCAACACGTTCTCAGGACGAATGGATCTCGCAGGAGTGCGCCGATCCATCATAAGAGGTCACGAGTGGGTCACATGAAAGAGAACTGAACGGTCCAGGGGCAAGAGCGGGGCGTGCTCTCCCCAGGTACACGCTTGCAGTGCGGGAAAAGAGACCTGAGAAGCCGTTTTTCTCCGCAATCTCGTTTGATCGCTTTCCTCATGCTTGCTTGTCTGAGTGGCAGCGCTCCAACATTCTTGAGAAAGACAGATGCAAAATCGACCCTTTTTTGACACTCATCGTTCAGCTTTTCTTCCCACGGGATGCATCCTCTCCGCGAGTGTGAACTTTGAGTTTGGGGCAGTCTCAAAAAATGTGCCAGAATCAAAGTGTCATTTTCCGCTAGGTGAGATGAGTAAGTGACACTTACAGTAGAGGTTTTTATGAAGGTTGGTTACATTCGTATCTCCAAACACGAGCAAAACGAGGCGTTACAGCGAGACGCTTTGAAAGAGGCGGGATGCGAGAAATATTTCAGTGATACCATGACTGGGGTCAAGTTCGAGCGAAAGGGATGAGAAAAAGCGCTGGCATTTCTCAGACCAGAAGATACGCTTGTCGTGTGGAAGCTTGACCGCCTGGGGCGCTCCCTTAAAGACCTCATTGAGACGCCAGGGCAAACGCATGAGAAATTGCACACACTAGTCCGACAGGTTACCGTATGGTCGCTGTGAAATCCGTCATGATCGTATGCAGTCGCTCGCTACTTTCAGCAAAGGCTTGCATGCGCTGAATAAGAAGCTCGTAACTTGAAGTGAGTCGTTCAAGCACGAAGCATTCACGGAGATCCCCTCTCACCATCAAGGATGCACACGTTGGATTTCATCGGATGGGAAAGGCACCGTTCGATTTTCCCCATGCAATTTCCAATACAAGTCGTTCATGATGGCTGCGATCGGTGCGTAGCGTTTGATGGTCGCCGCAATTGAAGTTGGCATGTTGATAGGATTGGCGCCCTGGGCATATCGGCGGATATATTCGTTGCGGACGCTGGCACTACGCGCGTCTGTGTAAACCATAACCAGCCAGTTGACCAGTTGTGTGACAGTGTAGCACTCGTCATGACTCATGTGGAGACCGAGAAAGGCCACCTCGGCCTCAGAAAGTTCGAAGCGCGGGGATGTGGCTAGACCGAAGTCGGCAAAATAGAGATGCCGACCGTCGGTCAGAATATTGTGGAAATGTGTGTCAAAATGCAGCAACCCCATCGCCTTCATGACCGCTACCCCCGTTTGCAAGCCTCGCTCCACGCTGGCGATGGCTTGCTCGACCGCCTCGCCGCCAAGAGCGAGCTGTGTTGTGAGCCATTGCTGGAGGTTCTGCGGGATGTATTCGAGAAACAGCACGACCTGGGCCGATGCTCGCGCAATCGCCTCAAGCCGCTCGCGCACCGCTGGGGAACCGTCCCAATATGCAACCATATGCTCTCTTTCCGCTTGCTCATCAGACATTGGCGCTTGTGTTGGGGATGGCCCTGGCAGCACGCGCCAGTGATACAGCAGCGGGAAGCACTCGCATTGCATTCCAAGCACCTCGTTGGTCGTCATCACATGTGTGGCCAGTTCCCGCCACGCGCCGAATCCGGTCGATCCTACGCCGTACTGGTAGAACGGAGGAAGATGGAATAGTAACCTTACTATAACTCCTCAGCCTCTTATGCGCAATTTCTTATGCGTTTGCCCTGCCCTTCCTCCTGATCTTGCTAGTACTGCGAATGTGGGTCAGGTTCTCAATCACGATAGTAGAGCCAGGGGTGGCGTTCTGAACGATATGTTTGGAGAGGACGTGAAAGCAGTCCCGGTGAAATCGCAAAGAGCGACCAGACAACTTTTTGAGATGTCGTTTTGCACTTTTTGTTCCTTTGGACTGAAGCTTACGGCGGCGCTCAACCTCCTTCCAGTGGTGAGAGCCAAGAAAGTGACGATTGGATGTGACAGCTGGGCGGTTGAGTCCCAAATCAACCCCAATTATCTCATCACTTTGAGACCCATCAGGGGCAGGGACACTCACCACAACATGCAACCAGTAGCGCCCATTGCGGATACACAGATCAGCAGTAGTGACCTGATAGCCTGCATACTTGCTGCTGTAGGGTGGAACTTGAAAGGGGATAAGAATACGCCCTTCAAGAGTGGAAAGGCTGACTTCTTGTGTCTGCCAGTTAAGGACATAGGTACGCTCATTGTAGCGAATAGGGCAGAGCTTGGATTGAGGTTGCCCTGCTTTACGTCCTTTTGCTTTGCGATCAAAGGCAGACTTCAA

Protein sequences of DBSCAN-SWA_3

>CP035758|3362951:3435333|3389116_3390166_+|QBD77258.1|DBSCAN-SWA
MIELRSDTFTLPTDSMRAAITQAVLGDDVYGEDPTVRRLEELAASICGKENSCLMPSGTMANLVALLVHCPRGFKALVGNESDIYIYEAGGASVCGSIMYEPIPTQPDGSLLISDLAAAMPEERDDPQYALPALLCLENTHNRCGGVVLDPTYLRRAAAFAHEQQMNIHLDGARIFHAATALRVGVAELVHEMDSLQFCLSKGLAAPIGSMLVGSRSFIEQARRMRKMLGGGMRQAGIIAAAGLVALEQMTDRLEEDHRHARLFAERLAEWPEIAITLKNVQTNIVLFKVIHERFTSKTVIEAAHQRGLNLSELGHGNIRAVFHYGITEKNVEQALEIISGLLHTTNQG
>CP035758|3362951:3435333|3420995_3421202_-|QBD77281.1|DBSCAN-SWA
MTHISLVLSIFCEMLGTTLLKCSYGFSQLLLTLLARIASVCNISLLSLVLTKMDVGMASASDPRWARR
>CP035758|3362951:3435333|3423447_3425019_+|QBD77283.1|DBSCAN-SWA
MNAPEPSPASTYGGEVETLAVEGNTGRLFPVASLLQQHAQKILSQDRELSLQRVVLDYDEAEHILEFRGVVAHHLPQLISTYRRSLVLVQELLRQHSPASLLSSSFHPLEDPSFAYQYVVPKPLYELFQGPLQVGSHVPFSALSKIYPTNPERGRGWSLELGAMAASIQPWNSLPLEGAASQIALLQAMGWMFNLLTANSPFLQGTLSDKRDYRLEVWGDHGLLASSRYLTDLALTKNLPTRPAGLTDYYRYVLRQQRPLVLPLRKETGSANEYKYTFLGIIQPNDTREFNALTYLQMDQVRAVDIETGEEQDVHPSVAHLFNGFDFLYYPRYGARIRLHLPEADQLDPKLFAQAVESRNEPLFHSLLRQAKVQTGFLCAEGRIPATVLPTHTHPGWERFSIPFVLQTALVRSQREVFTFLASTPLTWYDLAHRLPSLCNERTQGFSACVKGINATELARQIWALARQRLTEEEVACVNNEIEEILDTRMAPAEEQVALFETLSQRTTKPSAFRQVIEHCSMI
>CP035758|3362951:3435333|3400011_3400245_+|QBD77264.1|DBSCAN-SWA
MQESEAPAMNNMQISGNGSQITGPFTTAGTDHVYCSVHPGMKLTVIVQHESKKQREIACPLLFAIVVRIRRLFVGHL
>CP035758|3362951:3435333|3385785_3386724_+|QBD77255.1|DBSCAN-SWA
MISGHLTAPGRDTSGRLIGTGKAFGTFGELLQGSLGPEHNNFLVTFPIDCYSYATFIAEPDNTRVSVWPDFKWKAQTLATAILKYYHLQPGGKLKIVSELPVGKGLASSSADLVATARAIASCFHLSIPLALLEQWMQQIEPSDGVMYPGIAAFYHQQVRLHTFFGNLPSLTIIGLDEGGSVDTIAFNHYPKPFTQEEVAEYKRLLEMTAMAVRQQDLASLGYIATRSAQLNQALNPKRTLKNLQEICQSISGLGVIVAHSGTCLGLLLSPQYPAYREQLRQAYDQISDLASTVLVYHSLCCVNTTLREHIS
>CP035758|3362951:3435333|3363283_3363520_+|QBD77247.1|DBSCAN-SWA
MKFQFIEEHKREYAVKTMCRVLSVSECGSSAWRKRPKSECEQKNEALTQHIRQLFEHNRQISGSPRKWHCYSDVPSQV
>CP035758|3362951:3435333|3413115_3414036_+|QBD77274.1|DBSCAN-SWA
MHTKTTSNNQATTPVREHYTTGIVTSQDGTSIGYRQYGHGPSIVLVQGGMGSAHNFHQLAGTLADTFTVYVPDRRGRGLSSPHSNDYSIQKDVEDLDALLMKTDARQVFGLSTGGLIVLRSALVLPTIHKLAIYEPALSVNGSTPLDWVKRYDKEMAQGNVAAALITGMLGPKMGPPIMQYIPRLLLEFLTKMMLAREDKNGSGEYLSMRTLAPTLHHDGQVLFEMSETLENFHTVQAKVLLLGGSKSAAFQKASLDALEKVLPHVTRVEFPGLDHGSVWNYDKQRNPGGKPELVAQELRRFFAEP
>CP035758|3362951:3435333|3429166_3430387_+|QBD77287.1|DBSCAN-SWA
MCAKRNPNTATQQQYPQARCIHQLIEQQVRCTPQALALTDGQQTMSYRELNERANQLAHCLQTLGIKPNVPVGACLERGIELIIGLLGILKAGGAYVPFDPTSPTERLAFMREDVQAPVLVTQSKLASRFSSQGTSVLCLDTDACWLTQQSMDDPYSGATGNDLAYVLYTSGSTGMPKGVQITHSNVLNLVFWHQNAFSLVPSDRASQQTSPAFDAAGWEIWPYLTCGASVHVIAESIRKQPLALRDWFLAKNITMAFLPTPLAEQVITLEWPHCTSLRFLLTGGDTLHRYPPASLPFTLVNNYGPTETTVVATSGPILPAARSASPPTIGRPIANTQIYILDEEGQQVAPGVVGELYIGGMELLVATFIDRSSQQNSLSPIPLRRSLGLVCIEQVIGAVIVKMEK
>CP035758|3362951:3435333|3414326_3414740_-|QBD77275.1|DBSCAN-SWA
MDYVYVEKNVPFTSKTPPYLTPEQRHTLTQIPADLPDREIVRYNTFTQQDPNLIKQRRRLYNRLGFAVQLAVLRFPGRPLKDLAGIACRVLAAIADQIQVSASAFARYGDRDNTLYEHLDEIRQKCKFRECGWREYL
>CP035758|3362951:3435333|3381373_3383923_+|QBD77254.1|DBSCAN-SWA
MKIKNVEDIYPLSPMQELMLVHTLANPQAHMLSQHLHYILHGQVDLLRLRAAWEHTVARHAVLRTAIIWEHMKKPLQIVRRQVELPWREEDWRGLATQMQDKQLEALQAENQVRGIDISKAPLMRITVIRTDEQIVHLIWNFHHILLDGWSRNLIFQEMLQIYSELQQGKVQVWEPVPPYRDYIAWLKQQDMEAARYFWQEMLSGFTQPTILQESDDTNQRIESAEGHLSEELILLDLQTTDKLVALVRENQLTMNTLLQGMWALLLSKYSGQKDIVIGITVSGRSADLAGISTMTGLFINNLPLRIQLSNSQQCVMAWLKDIQSWQNRMRLYEYTPLSAIQAWSGIDLGQRLFETMVIFENYPKAELENDPHLSVQEISGGARTGYPLTLIAEGGPMLIMEVSYETGRFSRDFILTLLEQLQHLLEQFCKQPQQSVSALQHLSGIQCNKRVQLKEQPIAQMPQENSTEQIRNRSGTRFVAPRDETEQRMTALWEEILNQRPLSVKDNFFRLGGHSFIALQLMERIRQEFGRELALSTLFQGATIEKLAAAIHHEGNQESPSPLVVLQGQGQKIPFFCIHPSGGNVLCYYDLATHLGTEQPFYALEDLSLYEKEIRQISIEEMASAYIKVIRQVQPAGPYLLGGWSFGGLVAFEMAQQLIQQSSSTALLALIDSRPPQVSIRLTDGNEVTILGRFAYDEGQRNGLELDIPLANLRQQPRDEALQYILTQMKLAGIVGPEIGLSWVHNFVKRAKAKIWAVANYQAQIYKGHITLFRTQKGIQQDLQRLELAVDKQYYDETYGWSSLSSQPVTVKTIAATHLSIVIEPAVRELARQLQTSIEAIQTARIQR
>CP035758|3362951:3435333|3426736_3428251_+|QBD77285.1|DBSCAN-SWA
MYISTEGFQMREHQQWPAMNLKKVEEVLNCHPDIQKAVVIVQEDTFGQEHLVAYLVPDPSRSGPLGQLLRLECAGTLAQHPTYELPNGMTVFQKGRNETELIYREIFEDKHYLSESMCLPEHACVFDVGANIGLFSLFIHQLCPTACIYAFEPIPSVFELLQLNMSLYAVQAHPFACGLSKEDKSELFTYYPHCSLLSGFLAQDEQERDVVKTFLLNQQQINESKQIPSLDELDTLLKERLITEQFVCPVKTVSSIMREQEIEQIDLLKIDVEKSELDVLLGIEEHDWLRIGQIVIEVHDLDDRVAQIQALLQRHGYRLHLTQDRFLEGTGLHYISAVQERYRPTSTAKIDLHREQTEDRGWQSPKALCDAVMQFSTTYLAPWELPSDFILLEHFPLFPDGRVDTSALPPLREQACSSKRSYTPETDEERILADIWTQILPVAKVQRHDNFFLLGGDSILGMQVVAQAREKGIDMNIMHLFQHPILTELAATVPSLPSTTKEER
>CP035758|3362951:3435333|3404706_3404967_+|QBD77268.1|DBSCAN-SWA
MTLEYDQERLSRYSVEWQPDDRHLSRVGAPRLYQHGYQSAQLELWQPGEVEWFVIIRDSSPARRRRRAARILVIQPPLLSDGTQRS
>CP035758|3362951:3435333|3431243_3432899_-|QBD77289.1|transposase|DBSCAN-SWA
MSLKSQPINPVPEETVRIARAVYPKGNVSIHMRDELGTIYEDESFAALFPKDGQPAEAPWRFALVTIIQFAEGLSDRQAADAVRGRIYLKYALGLELSDSGFDASVLSEFRARLIAGQGEEQLLTAMLTLFKQRGWLKARGKQRTDSTHVLAKIRALNRLVCVGETLRHTLKCLAIVAPEWLREHSQPEWADCSGVRLEDSRLPSGEEERQEWIRHVGQDGANVLSALYEPEAPAWLREVPAVEILRRVWTQNYLWSEGKLCWRAADNIPPATLYLSSPYDVDAHYGKKRTTSWVGFKVHLTETREKDQPHLITHVETTTAPISDDVSTPTIHEGLRHKGLLPEQHIVDAGYVDAQLFHQSQQDYDIDLVGPPHPDVKWQARQQTGFAAGQFAIDWQTQQAVCPEGHASMSWTPAIDNRHNEVIKIKFSTKDCQSCPSRPLCTHSTRVPRRTITVRREQAHQALQRARARATTEEVKTLYAQRAGVEGTISQGVRVMGLRRSRYIGQEKTHLQHVATAAALNIVRVVRWQDGVPHAQTRHSPLLQLLRPVA
>CP035758|3362951:3435333|3403550_3403850_+|QBD77267.1|DBSCAN-SWA
MANFDGEFFIFNRNSGKVIVVAGGSRDNGANICQWQYSGNDDQKWTLETTDGEYYTIKNRNSGKVIVVAGGSRDNGANICQWQHSGNTDQQWSLLKITK
>CP035758|3362951:3435333|3418168_3418636_-|QBD77278.1|DBSCAN-SWA
MNTRIAKNILAHICYASLATTSQSGLPWCSPVYVAFDRNHHFYWISARQAHHSQNIREHRQIAAVLYDSTVSEGTGKGVYIQAIAQELSDPDEIASGLLAVFGRAGEQPPAIEIVRGNSPLRIYKAEMQAAWINVGGQVNGTPIEQRVEINLNNL
>CP035758|3362951:3435333|3405265_3405685_-|QBD77269.1|DBSCAN-SWA
MANQNHVNLLKKSVQEWNAWREQNPSITPDLSNADLTGAYLIGPEFNTGVNLNNANLTGAYLTGAYLGCADLTGAYLRGAGFDHHTNLNNANLGGAYLGEANLQIADLTGAYLGCANLQRAHLQSTDLTGAYLIGAIGI
>CP035758|3362951:3435333|3390193_3395458_+|QBD77259.1|DBSCAN-SWA
MYAHSRACNQKKGVSMFHPYNPAPFASGISPLQRDNTAPRSGLSSMQQLFEEQKERSPQALAVCDQQQTLTYCELDERATRLAIYLRMLGVQAEMRIGLCLPRQLDLPVALLAILKAGGTSVPLDPAYPQERFHFLLEDAQVSFVITNSQILQNLQLSDTETLQYLCLDLLTDLPGLTAENLARLAPIYPEQLAYVIYTSGSTGQPKGAAITHRSAFALLQWCQQRFSTEELAGTLASTSICFDLAIFEFFAPWSVGGCVLLVENALFLPYLNTSQPVTLINTVPSILRELLRLGPLPQSVKTVCLAGEALPLALVQQLAEQRQISRLYNLYGPSEDTTYSTEALLPLDIQKVTIGCPITGTKAYILNEEGSRVAPGETGELYLAGSGLARGYLNRPELTAERFVPCPWEPAGGRMYRTGDLVCQEPDGQLRYLGRSDQQVKLHGYRVELGEIETVINRMPGIAQAIVMVRNRREDDQRLVAYIVASDTNHGPDAEQLRTWVGQRLPAYMVPALVHELTAFPLTPNGKIDRKQLPEPDWSILHEIRSQGTPPASEEERQIAAIWEEVLGLKGISREENFFTLGGHSLLVLQVLARLQERLHVHVPVRVIFEQATITQLAAFISATRSDGFTDSIPFVKVPQDQVIPASSSQERVWFIQQLIPHNQAYHFQATLRLNGKLHLNALEASLSEIISRHEIFRTTFPNQGGKPIQVVHQAEPVHVPIINLEQEPQEQREATLKELIARELDRDMDINQLPLIRWTLFRISERDNLLLHVEHHLVHDGWSFNIFLREFVALYTASIEERPSPLPELAFQFRDYTYWQQQWLQSQEARDQIAYWKTQLADSPPVLAMPTDHPRPDVPTFTGRVPRIELPVELCRKLRALSHEAGVTLFMTMLAAFQILLYRYTNQPDLCVGTAVANRNRKETETIIGMFVNNVTLRTRINDHESFFQLLKQVRTVTLDAYANQDVPFDKVVEAVHPIRELRYNPLYQVMFSFHDSPLPDMRVPDVHITLTEAISNGSAKFDLAIIAIPRAEQRVGQHHTEHADAEGITLLWEYSHDLFTDSSMERMIDHYQRLLTDIVADPTKSLRDFKLLSEEETAQAITTWNNTYQPRPLALPLIAEQFAMQVARTPDNQALSFAGEQITYYELDCRANQLGHHLRSLGVGPNTVVGVYLEPSLEMIVAVLGLLKAGGVLLPVDSSLPLAQIVYLLQDTGARTILSHTQNRAVLQALAQELPQQLSNLVLLDQSEETFDLPAELQVWTRNDTKGFPDTSCPLTVKGTDLAYIIYTSGSTGRPKGVAITQRNIAEYFDAALDHYAPQPDDRVIQNHRLSFDFSIWEIFGPLLRGASLYLVPRQVSRDIGALTQLISEQQITILNMTPSQFTTLLEYVLLLQPTALQSLRLIVMGGETFPLALARKALNILPENCKLYNDYGPTEATIGCTAFHVTQANLEKYSNLASVPIGKPMNNMQLYVLDNAMNPVPVNVAGELYIGGVCIGSGYLNRPELTAACFVVDPYGQEAGTRLYKTGDLARYLPDGAIELLGRIDDQIKFRGFRIELGEIEAVLREHPQVQEAVVILHKRAENDQQIIAYIHMGSGQTASLNELRTHLKARLPEYMIPSTFIFIEQMPLNTNGKIDRKALPEPDQTARMSAEVQYIAPRNQIEETVAMIWADILNVNPISTQANFFELGGHSLLATQVVSRLLEAFHILIPIRSIFEKPTIAQLSAEIGDTLIEQADNDTLEKLLIELES
>CP035758|3362951:3435333|3363600_3363789_+|QBD77248.1|DBSCAN-SWA
MSRKGNCWDNAPTESFFGTLKREWTHRLSYQTQAQARQSVLTREKRSPTASAVILRSVISVL
>CP035758|3362951:3435333|3434739_3435333_-|QBD77291.1|transposase|DBSCAN-SWA
MKSAFDRKAKGRKAGQPQSKLCPIRYNERTYVLNWQTQEVSLSTLEGRILIPFQVPPYSSKYAGYQVTTADLCIRNGRYWLHVVVSVPAPDGSQSDEIIGVDLGLNRPAVTSNRHFLGSHHWKEVERRRKLQSKGTKSAKRHLKKLSGRSLRFHRDCFHVLSKHIVQNATPGSTIVIENLTHIRSTSKIRRKGRANA
>CP035758|3362951:3435333|3425181_3426426_-|QBD77284.1|DBSCAN-SWA
MALSSGQEKNETLSLYHLLDPEVLANPYPLYHQLRSTDPVHWDPYLHAWVVTRYADVVTVFQRFSANRTPTSQQLSALGLHKLAPLAQVMVHQMLFLDPPAHSRVRTLASRAFTPRRIEVLRAHIQDITNTLLDAVLQKRHMEVIKDLAYPLPAIVTAEMLGVPTEDWPQLTAWSADFAQVLGNFQHNPDFASRALKSLEEMIAYFQAAVKQQRAHAREGLLNALLITEINGDRLTEEEVIANTIVTMVGGQETTTNLIGNGMLTLLRHPDQLERLRQDPSLLPSAIEELLRFESPSQHTARLAPQDVKLGGKHISKREAVIAVMGAANRDPQRFPDPDLLDLGRQDNRHVAFAWGNHFCFGAPLARLEGQIAFESVLRRMPSLQLEPQPISWRANLGLRGLNELHVGIHEPRA
>CP035758|3362951:3435333|3410089_3412864_+|QBD77273.1|DBSCAN-SWA
MPESSLLVTKFTIPPLRSTLLPREHLFTVLNQSRSYPLTLLSASAGYGKTTLLSAWASQRSGQVAWLALDEQDNDPARFWAYVIAALRKAGSPAGEATLAMSHFPQPAHLSSALTLLINELSTLGQETILILDDYHLIKEPTIHESLQFLLDHLPACLHLLLATRGDPPLALARLRARGQMVEIRDTDLRLDSAEAASFLTQVMVLSLSEEEIRLLETRTEGWVAGLQLAALSLRRHADVSAFLQAFSGSQRFILDYVQEEILGPLPESYQRFLLYTSVLERMNAEVCQALSGEQASQQMLEALERANLFLVPLDEERRWYRFHTLFREVLLARLQATQPEQVLHLHREAALWYHQQGWPHEAISHARATQDALFMAELLEGYVEQLYLQGEIKTLLAWIKLLPQEILRAHPLLATSYIFAFRMLSPFSDQEERVYLHQLREGVEQTVQSEDQRRLSLAEQERLRYRLTLLDGWELMTQALADGNGEQLSRAAEQMEHLEFSDDTMWQQHRLAPFAIAWRMAGDFLPMVTALQESRKRTRMAQNRYQEAQILWGLIAALIALGRLSQAHDHNQELQQLVNRLGGPLPEAAYPNLFQAQLAYAWNRLEEAKSAAHKAIEQTAPLQYLDILIGASEVLISLYLAQDDQASAEQVVREMERMHHAAEIALIRPWLESFRVHLWLAQGDLTRAANWAEHTSSRQESLIYSRESASLALVRVYLAQQRYPQALHLLTDLLESAEQVARRGSVISILALQVVALQGLGATQGALRVLHRLLTLTEPEGYVRVFLDAGQPMHQALQAWLTTKHMRAAIFPAPPALVSYVSTVLASFASEQHQIVQQEIILPGSKALPRPSSQTAQQLLEPLTPRELEVLHLLAAGASNQEIANQLVVSLATAKKHVAGILSKLGAENRTQAIAYARALSLL
>CP035758|3362951:3435333|3406204_3406480_+|QBD77270.1|DBSCAN-SWA
MRERSGYGLLHELRLHAPKWRLDFATAEARSLVAADELPKRATVAHLGTSGQAPSRDLGQCQQEAIGTLALLRSNEGAHHPLLPERRFICL
>CP035758|3362951:3435333|3401528_3401960_-|QBD77266.1|DBSCAN-SWA
MEKASCTEQLERAEHGDTLQTESPYATQLIPVASSIFSFLCEDELHAAFSNALSERLRAQCNQLYSLAHLLPSLLQTRSALNMFFDEQYPPLNGNATVLPQETSSQILLIQQRWRKWLIYCGLALICMLIGFDIFGLLILYGR
>CP035758|3362951:3435333|3395737_3396967_+|QBD77260.1|DBSCAN-SWA
MGKVTSYKVTGKDESAKSVKSFEDLRAIGNTERVEMEYAYGPDLLPANPWSNSGMWRYLALLPTQDEILYPLAVGGTPLLAPLPLRQLAGLPGLWLKDETRSPTGSNKDRATALSLEYALHNKIQTISCASTGNVALSLAVGAAACGLKAVIFVPASILDSKLQYMRVTGATIFKVKEGYEAAVRLSREAAHAFGWYDRNTGYNPLTLEAKKTVAFEIWEQMGHQVPDSVVVPVGDGVTLNGLAKGFRELMFCGATTKLPRIIGVQAENCQPLKRMWEGHSVFPCDHKSTIADGIAVEAPINAGMALRDIRESRGGFVAVSEEALLNAIALLATTSGILAEPAGAAALAGIRPAVEQGLLKVHETFVVLVTGSGFKTPQYLRPPTHSPVYEILADINELKQIRAHSNCK
>CP035758|3362951:3435333|3428296_3429112_+|QBD77286.1|DBSCAN-SWA
MVSERHPDFHTWVIRARPNPHARLRLFCFPYSGKGASLFHTWSQELPPDIEVCAIELPGRESRFREPPFTQLVPLVQELAEVLHPYLDVPFAFFGHCVGSLISFTLARQLRRSYQVTPAFLFLAAHRAPQLPSRQIPLHALPDSEFLEGVHCLNGITEETFQNSMLMQLVLPSLRADFTLGETYQYEEDEPFACPLVVFGGRKDHLVSNEELVAWHIQTRSDFTFHLLEGGHFFLHESRQELLSEISKKILYWSDGTLRPNQSLSPNTSWR
>CP035758|3362951:3435333|3366551_3369974_+|QBD77251.1|DBSCAN-SWA
MTDRHLRIAALPPEKRHELLQKLAERKQQQERSEAKLIHLGRQTRSFPLSFAQQRLWFLDQLIPASPLYTIPYAVRISGLLEPEILRASLQQIVERHESLRTRFITENGQVRQIIDEYKQLSLTVSTLEGTPEQQAQIIQQQLLAEVRRPFDLEHGPLIRASLLQTGPAEYILQLPMHHIISDGWSNAILMRELMEIYTSLLDGRDAKLDPLAVQYPDFAVWQRQWLQGSLLDQQLTYWQKQLAGVPEAMDLPIDHPYPAQQTYRGALERLRLPVPLVKQMRAACQREEVTLFMFLLTAFQVLLARYTRQDDIVVGTDVANRSRRETEQLVGFFVNQLVLRTDLSNNPTFRQALKRVREVALGAYAHQDMPFDKLVEILQPERDLRHHPLFQVSFVLQNTPNPFQQAGNLSIQPLEINSGIAKLALDLTIDEKGDELALTLRYQQDIFEAGTMQRMLAHYQQLLQSAVEHGEDPIASLNLLTPSERHNLLYRWNVNEGIAEENQHCYHELFEQQVERTPEARAVIDGDLEFTYAQVNRLANRQAHRLQDVGVEPGVLVALGMTRGISLLLSILAVFKSGGAYLPLETTDPAERLVGMLKDSGSQLLLTTRALAPTLDEVCQQGQIAPRIMLVEDLLAVEQRNTNLTVTQTPRDLAYIIYTSGSTGRPKGVMIEQEGMLNHLRAKVQILHLDEHDIVPQTASHCFDISIWQFLAALLVGGTVQIFPDTITQEPQQLLPRLDQAGVTLLEAVPSVLQVMLDTAMESGDGLPTLASMRWLISTGETLPVQLCRRWQQRYPAIPVINTYGATECSDDTAHHIQQQLLGENELQVPLGLPIAGARQYVLDQELQPVPVGIIGEVYLGGIPVGRGYVGDPVRTAAAFLPDPFSTRPGTRLYKTGDLARLQPDGNPLFAGRIDDQVKIHGHRIELSEIEAVLASHPCVRECTVIIREDMTQDKELAAYIVPERGQTLCPVDELRSYLQRRLPNYMLPTGFVELTTLPLTSNGKLNRRALPKPERMAIASTAAFLPPRNDVEEVIAGIWSEILQVEHIGRTDNFFALGGHSLLATRIIAQVRAVFRIPLPLRVLFEQPTVEKLASILVDQEPVPGQVEKIARLMKQVEQMSIPEKQKSLEPGQGKENE
>CP035758|3362951:3435333|3362951_3363287_+|QBD77246.1|transposase|DBSCAN-SWA
MWNIRDSTKRGRKMSKEQKIYTKEFKIEAVRLAETSGKPITEIARDLGVSDSTIHNWRKQFSEHGEQAFPESEHQTPEAEELRRLKRELEVVKQERDIVKKALRIFLRQER
>CP035758|3362951:3435333|3386740_3387787_+|QBD77256.1|DBSCAN-SWA
MLYKNIIESIGKTPLVQLQLDGGAQGNVYGKLELLNPFGMKDRVAKQIILDARRKGVLKDGAPIIESSSGTMALGIALVGTALGHSVHIVTDPRIDTLTLTKLRALGCTIHVVDKMTDKGWQGARLERLHELMNLHSGAFWPRQYENPGNPYAYTDLANELIEDLGQVDILVASVGSGGSLSGTARALRQRQQSLHVVAVDAVGSVIFGQPDSPKRLQSGLGNSLVPKNVAHALVNEVHWLNDAEAFAATLDLAHTEKIFAGNSSGSVYAVARWLSHTVKAGTNIVAIFPDRGDRYLNTIYNESYRIDKGVNQGHLPAQPEQVTPDTAVQSWSFTQLKRLPLGAGARA
>CP035758|3362951:3435333|3369973_3376603_+|QBD77252.1|DBSCAN-SWA
MSEPETLQEMNKKLALLNRLLEQTPGIQQIGEEVPRITRRAKDVAPPLSFAQEGMWFIDQLQMDRNAYVMPVAYRIEGMLDSSLLERCLNEIIRRHESLRTTFALRDGAPVQQIAPELMIKLTDVHMQMLDDGEREQQAHAQILALASQPMNLHTGPLVRATLFHLEKDVHIFLFVIHHILFDGWSTGLLLKEIAALYEAFSQKQPSPLAELPIQYADYAIWQRQWMQNSSQQVHLDYWQQKLESAPHHLELATDHARPLTPTFHGDAHTLRISRELTNALQNLSLQAEATPFMTCLAAFIILLARYTGQNDIVVGSAIAGRQQLEVEHLMGLFVNTLVLRTRLDSEQTFLDVLAEVRETALEAYTHQDVPFAKLVQLLQPERQSGRNPLFQVLFAFEQLSTDQATFAQMRWQDYAIGQETTKFDLSLYVHQIDQHFEITLAYNTDLFESATTLYMLQHYQTLLEQIVVAPQQRQATISLLSDSERKQILGEWYQTAAIYPDQSTLQSLFENQVDQAPEHVAVVFQDQHLTYQVLNQRANRLAHDLLRQGAGPGTQLGICVERSLDMLIGILAIIKTGGAYVPLDATYPEERLAFMVRDADVHLILTRHNLLPYLPAQACTFICLDDNPGSEQEHNPADLACADDLAYIMYTSGSTGQPKGVSAVQRGVIRLVKNTNYMCFDRSETFLAFAPISFDASTLEIWGPLLNGGRLVILPPAIPASEELTNTLTRYGVTTLWLTAGLFHQVVEQNLDDLTTVRQLLAGGDVLSIAHVQKVLRSGKVERLINGYGPTENTTFTCCYSMQKPLPDGQTSVPIGRPIANTQVYLLDDDMQPVPVGIPGELYIGGDGLARSYYKRPGLTAEHFLPDPISGQAGARLYRSGDLARYLPDGTLQFLGRNDRQVKVRGFRIELAEIDAAIGQLPGILQVSTQVYTESESDNKILIAYLVVDPAQPFTSEQMRSALQERLPAYMVPALFIKLPELPLTPNGKIDREALPGPEFARSNMLEHFVAPASTGEKLLADIWSKVLGISEIGIYDNFFALGGDSIRSIRIRSQLKQAGIDLSLQQIFQHQTIHALAQVLPAEGIKQGAALPTSAFSLISENDRAHLPAEVEDAYPLTRLQAGMIYHAELAGDGSVYHNVLSLTLHSKQIDLDLLEQAILQAIHQHPVLRTAFDMSTYSQPLQLVYRIAKPVIFREDIQHKTDAEKQISIDNLIRYERSHTFDLNQPCLLRCFVHLRSATTLQLTVTFSHTILDGWSLYGILADIFTAYTTGLAKGQLPPLDTFKTSFRDFVYLEQQALQSSENRAYWQKQLQDASILTLPRWPQRTKAGDRRIKTLRYIVPQEGLKSLARLASVPLKSVLLAAHSKVLQMISGQSDILTGVTTDGRPEELDGDRIRGLFLNVLPFRIQLCAESWYDLVQKCFQIEREALPFRRYPLSEMQNAIGGQELLQTLFTFEHFHTIQQANETGAISILDSISYGDASFALSVDFGLDPASHQLTLRLDFARAVFCDEQMEAICAYYQQILHAMATRPEEHHETRSFLTSSEYQRQIETWNRRLTETTGTKGFSQLFNEQVARTPDALAIITQERHVTYHELQQEVERLAAHLQHLGVGPEQIVALLLERGIELISAFLALWQIGAACLPLDPTHPDNRYQQMFSQSRSRLVLTMHQHVERIQRVVAAWPEEERPAIVQLEKLPPQRGLPLEPVAYQPQRLAYIMFTSGSTGIPKGACVEQEGMLNHMQAKVADVELRAGQRLAQNSPVGFDIVIWQCLAPFLVGATVTVAGDELAFDPGNLLRWLQKQRISVLQVVPSMMRALLQEVEHTSIVLPDLHWIVPTGDALPTDVCTRWLNLFPQIPVLNTYGSTECSDDQCHVAIRHAPGSDYELPIIPIGHPIPGMRAYILDQWYMPVPVGVAGDLYIGGTGVGRGYLHDPAKTAEVFLPDPFARAAGARMYRTRDLARFLPGGEIEFLGRVDQVIKIRGHRIEPGEIEKTLLQHPAVQDCVVVVHQEEQRDKILVAYIVPQQPGGEEKTGIGEMLRQFLGEKLPAHMVPGVFVLLETLPLNSNGKVDRKQLPPPTGQQARDGEVFVTPRTALEQIINDIFAEILHRERISIHEHFFECGGHSLLATQVISRIRSMLQIDLPLKMLFTYPTTARLAAAILEHKAEQRQQIEKIALLLVELAALSDEEVDQLFAEKIVTTEENN
>CP035758|3362951:3435333|3408325_3409207_-|QBD77272.1|DBSCAN-SWA
MKLGLHMNDFTWQGGASLIGPTLVKIAQIADVTGFDRISLGDHVWQSAYLGGVEREQLSCYETLAYLSAHTRRIKLIAMVTATPYWQPIRLAKTVTTLDVLSGGRAWLGIGAGDYEEEARGSGLPFPPTKERYEMLEEAIQICLRMWHGERGDERPFEGTSYQIPRPLNVPQSLTRPHPPILIAGSGEQRTLRLVARYADACNLRPGQEIPKKLAILRQHCETEKREYDTIEKTCMFAFDVGKDGSKASELIEHLRWLAGMGIQTVLGVIPQIDTITPLEVIGREVIPAVAAL
>CP035758|3362951:3435333|3416626_3417958_+|QBD77277.1|DBSCAN-SWA
MALRFAVEAREAIREHLAALFASEPATPEQTEETHGGSAVLEPISPEEASPGPFPLPTSLSQTRRDDLAADNAARHDWIAEEGRPQREVHGTYQRTADLRISTTDPDATPMRLKGGGTHLGYHTHYVVDGGRSRIILSVLVVPGEVNDNQPILDLIWRILFRWRLRPRQVTGDMMYGTIEIIKALEDAHIRAYIPVAERGQRAGYYGLAQFTYDAFHDQFTCPQGHILRPAYRLEGSQEVQYRADAAICNACPVKSACTESNRGRHVHHPFLADYLDRVKAYEAIFAYQKALNKRKVWVEPLFGEGKQWHGMRRFRLRRLWRVNCEALVIASGQNLKRLLQKRGWGRRPFPSEAVAMALPLASPIEKPPTNRSKTIHRRKVAVAEMISLGLNNRQSYAYILCFSLNSHFMTIFLILSSSPISLLPSFLLYQIEMGNFLAHPFS
>CP035758|3362951:3435333|3387857_3389120_+|QBD77257.1|DBSCAN-SWA
MSPKLVFVESNTTGTGLLALSKAREMGLTPIFLTNNPQRYPGLEQQPCRVIICDTNSGERLQETIDVLDPDSICGITTTSEFYLVNVAQLTQLHGLPGNPAQAVARCRNKAAMRHYLAAVGMQQPAFVEVRRLSDLDTAIEQVGLPCVAKPVDDTASNAVRFCASRQDVEEQVSSILSLTRNIRGQRTAQAALLEAFIDAAEYSVETFSWQGHTTCLGITEKHLTAFPYFVEERHFFPAALSPASEQEMRNTVLQALEALGIAHGPAHTEVKLTTHGCQIIEINARLAGGMIPELIRYTSGIDLIEQQIKAVTGHEPDLNLRAQGCAGIQFLVSREQGWTKNIEGLSVARAVNGIKQITLTSAPGKQVNPPRSAYDRLGYIIAHTASYEQTTCALQTASSQIHLAVRNDSGNRVVEEFHV
>CP035758|3362951:3435333|3400279_3401212_-|QBD77265.1|DBSCAN-SWA
MFCFKKYRFSERGRIMAFHADVVYGLGNDRELRLDIFPPDPHKNQRTAVLLVHGGGWRRNSRHMLRPHAEKLSSLGFTCCTVEYRFVQEAPWPAPLHDVKAAIRWARSHAEELGIDPERIVLQGYSSGGHLSLIAAGTPDQSEFEGKGGCAGVSTRVAAAMAVYPALVFFRDPEEAIFGNHYPPADEAAWEQHKLNQEGFPSWPLLGLNATAEAMQQVSPFSYISPAFPPTLLLHGTSDIHVPYPPTVRFHQALLAAGVQCDLHLYSGQSHGFDLSKSFRDVVQEEAALFFRRIVSEPEMVNKELKETTA
>CP035758|3362951:3435333|3421216_3422437_-|QBD77282.1|DBSCAN-SWA
MVHQQSLLDAWGFTSFVAALQERSLWHEPSFLESPAYDTIRLGQKELVNLAGISFLGFQQDEEILEHFLEATRRYGIVTAGSRLAQGVSQAHQQVEEFYCHLTGKERALSFASGCLANLGFLHAMGTRFGTKKLCGLDNRETVFLLDRDCHWSLRKGVEGFPQHEYFPHNDPIHLEQMLARLQGAKIVVVFESVYSTDGGVAPIGTLLDVCERYGAVSFVDDANGFLIYGPSQRPFAQEFAHLGRATFVMTSFSKSVGLEGGIIAGPADAIRAFEFLSGTSIFTAAIQPPTASTIHFIMHKLVEQPALVDGYLEQVALFRRRLEAIGCRLNPTPTYITSILVGDDEKVEPVRRGLFERGYLVTVFHYPAVRFNHAMIRILPNRMHTSEQIEGFLQALTAVKEDYQF
>CP035758|3362951:3435333|3433871_3434621_-|QBD77290.1|DBSCAN-SWA
MMTTNEVLGMQCECFPLLYHWRVLPGPSPTQAPMSDEQAEREHMVAYWDGSPAVRERLEAIARASAQVVLFLEYIPQNLQQWLTTQLALGGEAVEQAIASVERGLQTGVAVMKAMGLLHFDTHFHNILTDGRHLYFADFGLATSPRFELSEAEVAFLGLHMSHDECYTVTQLVNWLVMVYTDARSASVRNEYIRRYAQGANPINMPTSIAATIKRYAPIAAIMNDLYWKLHGENRTVPFPSDEIQRVHP
>CP035758|3362951:3435333|3364006_3364402_-|QBD77249.1|transposase|DBSCAN-SWA
MMLEVSSLLSLPAGLEIAEITETSDLVIVHVVTTSPIKAYPLCSEFATHVCSYYTRKVSDLQWAGQHVQLLFHVRKFRCDTATCPRKVFAEHLDSFVEAWARQTKRSHEAIEAIGLSTCGKGEHDWLTVWV
>CP035758|3362951:3435333|3430338_3431025_+|QBD77288.1|DBSCAN-SWA
MYRTGDRGRYRENGEIEFLGRTDFQINLHGYRIEPNEIVTLLNEQAGVKTSAVIAREDSVRGKYLVAYIVPEADSCISENALRAVLEKRLPHYMIPTTFVQLETLPLTAHGKLDRAAFPEPHLLNSLHDNAAEQTQTPLEAQLAVIVTQLMGLERVGRDENFFLLGGHSLLGTQLIMRIAATFGVELPLRTLFEYPTIRHLAAEIEQRIPAGGLLPEEKEKSAFSSQQ
>CP035758|3362951:3435333|3376606_3381331_+|QBD77253.1|DBSCAN-SWA
MINPSSEQKRREIANKRRALLDMRLRDEGIKELASQSIRPRDPQTRPVPSFSQRSLWFLNQLEPESGLYNITHAYRLSGKLDILVLRRSLNAMLRRHESLRTTFGIIKDEVIIQLTDAQESELEIYDLRSLPEVEREIRAREITRQQAQRAFNLARGPLLRTMVILINNQMQILIIQMHHSISDAWSMSIFSKELSQIYTACMQGLAFSLPELPVQYPDFALWQRSRLQGAYLQQQIDYWKNQLQDSPALLQLSGSKPRPAVLDHWGAWINSTLPRELVRNLKLLSQRTECTMFMILLAAFAVLLARYSGQDDIVIGSPIAGRTLAEEETLIGFFTNTLVLRIKLHSQDSVLDLLQQVRETTLEAYTHQDIPFEKLVDALQPERRLNYNPLFQVLLAFQSAPACDLSFAHLQVEPYEIGQQQTRFDLAWYVDAHEEDLTITAGYSLELFDTALIEQMVQHMETLLWSMATNPEQRCADLKLISSAESLHLLKERNQVTRVERPGLLIQQIITQMSTEKPDLPALAMGELTLTYAELNRQANQLAHYLQGQGVGPEVRVGLLVERAPETIIALLAILKAGGAFLPLDQSYPLKRLQMLLDDAQVRLVIGRKTPASSLDSQRYDLICLEEISEMLARLPETDPISMVAEANLAYIIYTSGSTGRPKGVTIEHRQIISYLASILAKLRPEPAATFALTTTLAADLGNTILWSALCTGGCLHILTREQVEDPIAMSAYLHWHPIDYIKMVPTHLNALLSISEASVPLPQQALILGGEATTSDLLQRIQQLAPACCILNHYGPTETTVGVLTRQVEANETCPLPLGQPLNHVRIYVLDQHLQAVPIGIAGEIYIGGAGVARGYWQNPVSSAERFLPDPFSNEAGARMYRSGDIALYRSNGDLYFLGRADFQVKIHGYRVELAEIEARLRQHPQIKDCLVLAHAETTGIYQLLAYIVPQTGQQPEEQELRSYSTQYLPGYMVPASFLFLEKMPLTANGKVDRHALPLPDPDGNKASTRSFVAPRTASEQQLTTIWSEVLHKEHIGIHDNYFSLGGDSILSIMIIARARRAGLYLTAKDMLQFQTIAELAPRIKREIVSEAEQGLVNGPVPLTPIQHWLFEQNLPEVQHHNQSLFVHIAEPLDSELLNIAFEYLITHHDALRLHFTRKNQIWKQTGGEPSEARVAFRTVDLALIDKQDQRTIMEEQARQAQQSLNLSGGPLIQARLFKAGSAEDQYLLIIIHHLIVDGVSWRLLLEDLQSIYRQLSQRQEVHLPAKTTSFRSWAQQLADYALTAQAEQEAEYWLQELARPFEAFPLDHPKCPNLMSTERTITCQLSHEQTYRLLQDVPARYRSGMNDGLLAALGMAYRAWNGQNILAITLEGHGREELFKQVDLSRTVGWFTSHFPVVLDLGGLQEPAAIIMAVKEHLNAIPHHGIGFGILRYLGRPEIRERLKATPVPGIKFNYLGQFDQSFTEGALFQRSAEEITGPDVSSRGSRPYIVEVDCSVINGQFNHNWRYSANLHNRETIERLAHCFQQALQQISTPDEHMGEMHFSASDFPLADLDEEQLGTLASMMADDNE
>CP035758|3362951:3435333|3397027_3397330_+|QBD77261.1|transposase|DBSCAN-SWA
MKMSREQKIYTKEFKIEAVRRAEASGKPIVEIARELGVSESTIHNWRKQFPQHSEQAFAGSGHQTPEAEELRRLKRELEVVKQERGIVKKALHIFSRHER
>CP035758|3362951:3435333|3399325_3399565_-|QBD77263.1|DBSCAN-SWA
MVYVKNVPTFERIVRVLVGSGLAVCAGWVYLQLMHGAWAVLLALVLLVSALFVAATGFFGWCPACALVGRKLMSSQRPS
>CP035758|3362951:3435333|3418639_3419800_-|QBD77279.1|DBSCAN-SWA
MDTQKNLSALTIQVFEQLDQIEARDWNGCCAAESAFSADYLQALARCELDCTFRYFVARKDGQVVGTSFGYLTRFPLFPLLHPRVFIGASPLTIGFPFGFSQSCSDQEILRTLIDGMIREASTQHAAMMVLRDVNKETLTTFKALEDTCRTLGFHRQPLFQQAWLHLRWVTFDDYLTALRARYRELVHRDLRRVQQAQCTLQVLPGSEARAFLPDLHRLWLQSYWKHQDPDQLLLPPAYFSQALTLPGCRVFLVQRLGHLLTFILTFEHASTLEAGHSGVDYALIGNIPAHRYAEYEIIRYAIDHCFERIDFGISHEANKQRLGCHLQGQYGYFCPLSPFARFLVGLHIDRWLLRKYGFAVAAPESQDGEIAPYVFRKPPELEERR
>CP035758|3362951:3435333|3407846_3408179_-|QBD77271.1|DBSCAN-SWA
MAPIIPKEQLQNGYLFQGKDYGGVPLSFFWMQLPPDEGPKLHFHPYDEIFLILEGRATFTVGESSLEVEAGNVVIGPAGVPHKFSNAGSGILRIVTLHPNPKTIGTRVEE
>CP035758|3362951:3435333|3416131_3416563_+|QBD77276.1|transposase|DBSCAN-SWA
MQWGRGGARTMMGFKERAFAPLVAVSLEELVPQDHFYRHLQKALDLSFVYDHVRGHYAVAGRPSIDPVVFFKLQLVMFFEDIRSERLLMRQVADRLSVRWYVGYELDEPLPDHSTLSKIRTRYGLEIFRRFFETIVEQCRQAK
>CP035758|3362951:3435333|3419827_3420853_-|QBD77280.1|DBSCAN-SWA
MSTKKQRGLSLDQQAELALPWAIRVAATLRLADFIAGGVTHLEDLASRAQVHPGALGMLLRYLSASGIFTERAPEHFELTHAARMLLDDHPQHLREQLDQEGVGGNMDRVWIGLLDSIRTGQAAYRAIYGCTFWEALSTNASLSAWFHPLMIRLSTEDADALVKSYDWTRVGHIVDVGGGMGSVLAALLHAYPALSGTLIELPETAARAQATFADRGLLERCSIVGKSFFEPLPPGKDIYLLSCVLFNWDDAPAIEILRRCAQAIGPQGRVLILEPLSGQEPIPRPVTAEELLTLVLLGGQIRSLETYANLAHCADLEICSAHRLTSGNTLIECAASAYGI
>CP035758|3362951:3435333|3384268_3385789_+|QBD83483.1|DBSCAN-SWA
MQDEKKMPANLTGRIAAGPHTSLDEDILTPQFHYDLAYLLPWYIQIEKVLLLEYRRMDLLNLEEALSIGTILNSIRRDTLQPKREENMSDIAFAIERQVEQSLSHLPGAWHVDRSRNDFQACAQLLSGREQLLAIIDQMVSFAWAVHRRASAMTEMIMPGYTHYQAAQVISPGFYLTALIEEMLASTTALLNIYDGLNTCPLGAGAMAGQQLPWDRVRMASLLGFDRPQRHALVSVASRDWRTRIAAELSTIGATLSRFITDLIAWGSGPYAFISLPDEFSGISSAMPQKKNFPVLERLRARTAHLTAYYQDFIMGQRNTSYTNLVEVSKEAGSQLSSMFTTMASLLRIFTLVIDQMEFQSETMRHACTQEYFGGFALANHLTLQAGISTRQGQVAAGKYIVQAIQQGFTPGQGSAHLLHAICQAQGYSADIAYHTLQELFDPEHNLQEKHTSGSTGTQAVEQMLREQTNDLQHVQTVRQSKQFQIEQALREIDRQLSGEKEVEDL
>CP035758|3362951:3435333|3399128_3399329_-|QBD77262.1|DBSCAN-SWA
MNSVPDAQLIPDAVDGDPAAIEQLLGKYHPSVTRFARKFCATPEDVEDAVQETLWIAAQRIGASLY
>CP035758|3362951:3435333|3364946_3365573_+|QBD77250.1|DBSCAN-SWA
MNNRLEREAEYVDYFVHLTSVTETLCGHAEGVANKLCEEVMKVTKGNAIIVMNSPQLNLQTTLLRCDPISVRFPVRFRGIVYGEMYIKASPHHPSYPSLPLPIAHALAQTCGLILHTLEVSALTLNRNQGNKGLHGAITKRQREVLVLMMHGYDQDAIAEALSISRATVSKHRQNIYQELGVHNEKDALLVAYQAGIVSPIEDISAND

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBD77246.1|3362951_3363287_+|transposase	transposase	NA	NA	NA	NA
QBD77247.1|3363283_3363520_+	hypothetical protein	NA	NA	NA	NA
QBD77248.1|3363600_3363789_+	hypothetical protein	A0A0P0I4A4	Acinetobacter_phage	2.6e-05	48.8
QBD77249.1|3364006_3364402_-|transposase	transposase family protein	NA	NA	NA	NA
QBD77250.1|3364946_3365573_+	response regulator transcription factor	NA	NA	NA	NA
QBD77251.1|3366551_3369974_+	amino acid adenylation domain-containing protein	A0A2K9KZV5	Tupanvirus	1.2e-90	25.7
QBD77252.1|3369973_3376603_+	amino acid adenylation domain-containing protein	A0A2K9KZV5	Tupanvirus	8.2e-133	25.9
QBD77253.1|3376606_3381331_+	amino acid adenylation domain-containing protein	A0A2K9KZV5	Tupanvirus	9.5e-91	26.7
QBD77254.1|3381373_3383923_+	non-ribosomal peptide synthetase	A0A2K9KZV5	Tupanvirus	6.6e-06	32.5
QBD83483.1|3384268_3385789_+	argininosuccinate lyase	NA	NA	NA	NA
QBD77255.1|3385785_3386724_+	kinase	NA	NA	NA	NA
QBD77256.1|3386740_3387787_+	cysteine synthase family protein	A0A1W6JIM2	Lactococcus_phage	4.4e-41	35.8
QBD77257.1|3387857_3389120_+	ATP-grasp domain-containing protein	NA	NA	NA	NA
QBD77258.1|3389116_3390166_+	threonine aldolase	NA	NA	NA	NA
QBD77259.1|3390193_3395458_+	amino acid adenylation domain-containing protein	A0A2K9KZV5	Tupanvirus	3.1e-90	24.1
QBD77260.1|3395737_3396967_+	pyridoxal-phosphate dependent enzyme	NA	NA	NA	NA
QBD77261.1|3397027_3397330_+|transposase	transposase	NA	NA	NA	NA
QBD77262.1|3399128_3399329_-	hypothetical protein	NA	NA	NA	NA
QBD77263.1|3399325_3399565_-	DUF2892 domain-containing protein	NA	NA	NA	NA
QBD77264.1|3400011_3400245_+	hypothetical protein	NA	NA	NA	NA
QBD77265.1|3400279_3401212_-	alpha/beta hydrolase	NA	NA	NA	NA
QBD77266.1|3401528_3401960_-	hypothetical protein	NA	NA	NA	NA
QBD77267.1|3403550_3403850_+	hypothetical protein	NA	NA	NA	NA
QBD77268.1|3404706_3404967_+	hypothetical protein	NA	NA	NA	NA
QBD77269.1|3405265_3405685_-	pentapeptide repeat-containing protein	NA	NA	NA	NA
QBD77270.1|3406204_3406480_+	hypothetical protein	NA	NA	NA	NA
QBD77271.1|3407846_3408179_-	cupin domain-containing protein	NA	NA	NA	NA
QBD77272.1|3408325_3409207_-	TIGR03560 family F420-dependent LLM class oxidoreductase	NA	NA	NA	NA
QBD77273.1|3410089_3412864_+	hypothetical protein	NA	NA	NA	NA
QBD77274.1|3413115_3414036_+	alpha/beta hydrolase	NA	NA	NA	NA
QBD77275.1|3414326_3414740_-	DUF4158 domain-containing protein	A0A1B0V7H9	Salmonella_phage	3.4e-13	38.5
QBD77276.1|3416131_3416563_+|transposase	transposase	NA	NA	NA	NA
QBD77277.1|3416626_3417958_+	hypothetical protein	NA	NA	NA	NA
QBD77278.1|3418168_3418636_-	pyridoxamine 5'-phosphate oxidase family protein	NA	NA	NA	NA
QBD77279.1|3418639_3419800_-	GNAT family N-acetyltransferase	NA	NA	NA	NA
QBD77280.1|3419827_3420853_-	hypothetical protein	NA	NA	NA	NA
QBD77281.1|3420995_3421202_-	hypothetical protein	NA	NA	NA	NA
QBD77282.1|3421216_3422437_-	pyridoxal phosphate-dependent aminotransferase family protein	NA	NA	NA	NA
QBD77283.1|3423447_3425019_+	hypothetical protein	NA	NA	NA	NA
QBD77284.1|3425181_3426426_-	cytochrome P450	NA	NA	NA	NA
QBD77285.1|3426736_3428251_+	FkbM family methyltransferase	NA	NA	NA	NA
QBD77286.1|3428296_3429112_+	thioesterase	NA	NA	NA	NA
QBD77287.1|3429166_3430387_+	hypothetical protein	A0A2K9KZV5	Tupanvirus	2.0e-37	30.2
QBD77288.1|3430338_3431025_+	hypothetical protein	NA	NA	NA	NA
QBD77289.1|3431243_3432899_-|transposase	IS1182 family transposase	NA	NA	NA	NA
QBD77290.1|3433871_3434621_-	protein kinase family protein	NA	NA	NA	NA
QBD77291.1|3434739_3435333_-|transposase	transposase	A0A1P8DJG9	Virus_Rctr71	1.3e-18	34.0

Sequences of DBSCAN-SWA_4

Nucleotide sequences of DBSCAN-SWA_4

>CP035758|3448468:3500639|DBSCAN-SWA
CATCGCTCAGCAAAAGGAGAACCAACCCCCATCGCAGGAGCAGCAGCAGCTCTCACCCTCAACCGTATCAGGAGCTTCTTCTGAGCAGGGGAACGGAGCCTCTTCTTTTCCAGTCACGAGCCTGGGCTTAGAGGGATATGCGAAAGCGCTTGAGCGTTTGGATGGGATTACCGGTGTCAACCGGAGGATAGCCGAAATCATCTTAGCCGAGATCGGGATCAATATGGATCAGTTCCCCAGTGATGGTCATCTCGCATCATGGGCTGGCATGTGTCCAGGGAGCAAAGTGAGTGCTGGGAAGCGATTGAGCGGGAAAACTACCAAAGGCAGTCCCTGGTTACGATCAGCTCTCGTTGAAGCGGCTCATGGAGCTGCTCGTAGTAAGGGCAGCTATCTGGGAGAACACTATCGGCGCTTAGCGAGACGTATTGGCAAGAGAAAGGCGATCATTGCGGTCGCCCACAGTATTTTGGTGATTATCTACCACATCCTCAAGGAAGAAAAAACCTATCAAGAGCTTGGGAGCACATACTTTGAAGAGCGGGAACATGATGCTGTCAAGCGGCGTGCCCTTCGCAACTTAGAACGACTCGGCTATGAAGTTGCTCTTCAGGAGAAAGAGCAAGCTGCATAATGTAGCTGCATTTTCTTACAATTGAGGAACATTTTCAGGAGATCCTTGTGAGGATGTTGTTATGAGGTCCACCGCATGCTACCCTCGTTGAGAGGAGGGGATGAAGCTCGGGTGCGTAACGTTAGGGCCGACCGTGTATTTGACATGGGATCTGTAAGCCCGCTTCCTTGTTTGATCGCTAGACCGACACGGGCTTATAGGACACAAAAGGCCGAAGCGAGGACGGCTGTATCAGCACTGCTACCTGTTCAGCGGGATACTGAGTTTCTTGAAATATTCTTACGAGATTGTGATGTTCTTGTTCTCCGGCTAGGGACCAACCCAAGATGTTGGAAAATGTCGAAATCGTGGGAAACGACTCTCCCATCTTGTACTCCGTTGCACCATTGAATGGAACATTCGCCCTTCTATACTTGGAATAGAGCCTGCAAATTTTATACGATGCCGGCCACTGACGCTTCAGGTACTTGAGGACAGGATAGAGGTCTTCCGATGGAGATTGTGTTGGAAGATGTTAACGTAATCCATCCTTCTTGTACTTTCATCGCAGATGCGGCAGTACGTCTTCGGAGAAAGACGGTTCAAACCATGATCAGTTCAAAGCCGAAAGGAGTTTTCCATGAAATTTCGCTTCCTTACTCTTTCACAGCATACCCCAAGGTTGCTTGCTCTCGGCCTCTGTGCCATTTTATTACTTACTGGTTTGGCAGTGTTTGCCGTGACTGGCCCAAATCCTGATGGGATACGCGTCAACGGGATCAAAGTTTCAAATCCTGATGCAGTACGTATAAATGGCATTGAAGCTTCAAATCCTGATGGGATACGCGTCAACGGGATCGAAGCTTCAAATCCTGATGGGATACGCGTCAACGGGATCGAAGTTTTCACTTCTGGGACAGCCTATCCCACCAGCATTGAGGCTTAGCACAATGCATCGCATCAATCGCATGCAATTCCAGACGCGGCAAGAGGCGCGATCGGTCATTTTTGAGTGCTTGGAGGGCTTGTACAATCCTGTCCGGTTCCATTCAACCTTCCAGTCTATGAGTCCAGGAGCTTTTGCTCATTTTCCTTTTCTTCCATGTCTGCCGATCGGACGTGTGGTGCTCTCGCTTGCTCAGAGGCAACTGAATTCGTCTTTTCTGTTGAAAGGATCGATAAATTTCCTAATTCCTTGAAACGCTCAGATAAGACATACGCATTGAGCGAGATGGATCAGGTATCGGGCAACATCATCCTGCTTGTTTCTCTATATCGGGGAGGAGAGGGCTATGACCATACATAGTGAAGTGATTGGAAGTTTACTCAGGCCGGCCTATTTACTTGAAGCGCGCAGACAGGTCGAGACAGGTCAGATCAGCGCTGCCACCTTCAAAGCCCTTGAGGACAGGGCAGTCGATGAGGCGATTGGCTTGCAGGAGGTAGCAGGCATCGAGGTGATTACCGATGGGGAGATGCGACGAGCTAGTTTCTTTGGGCATCTGGTCGACGCGCTCGAAGGTTTCGACCCCTCAGGAGGCCGGCGTCTTCCTATGAAGGATGAGGAAGGCGGACAATTCTTCGCTCCGACACCCGTGGTGGTGGAGAAACTCAAGTGGCGCAGGAGCATGTGCGCTGAAGAGTGGGTCTATCTGCGTGCGCGTCGAAAGGGCCCTCTCAAAGTTACGCTGGTCAGTGCCCAACCGTACTATGATCCTCAGAAATCAAGAGAGGCCTATCCTTCTTACGATGCCTATCTGGCGGATGTAGTGGAGATTGCACGGCGTGAGGTGCAGGAACTGCGTCGACTGGGGTGTTCGTATATTCAACTCGATGCACCTCAGTACGCCTCATTGCTCGATCCAGATATCCGAGCAGCATTGCGCCAACGAGGCATTGATCCTGACAAGAGTCTAGATCTCCAGATTGCATGCGATAATGCGATTATTGACGCGCAGCCAGGCGTCACCTTTGGCCTTCACATCTGTCGTGGCAATAATCAGAGCAAATTTTACGCCAGTGGAGATTATGAGCCGATTGCACGGGTATTTAGGCAAACACGTTTTCAGCGTTTCTTGTTGGAATATGATGATCCACGCTCAGGAGGATTTGAGCCTCTGCAGCATGTACCACAAGACCGTTTCGTAGTCCTGGGTCTGGTCAGCACAAAACGGCCGCAGCTAGAAACAGCTGCCCAGTTACGAGAGCGCATTGAGCAAGCTGCACGTTTTTTCCCTCTGGAGCAGCTGGCACTCAGCCCGCAATGCGGTTTTGCTTCGACGATGGAAGGAAATTCTCTCTCGCCTCAAGATCAGCAGCGCAAGTTGAAGCTGGTAGCTCAAGTGGCCAGACAGGTCTGGGGATAAGAGTGTTATTCATAAGGTTTGGGATATAGCTGCTAATTTTATGGACATGCATTTCAATGTCCACGAAACCAGCGTTAAGCTACGTCCGTTGCAGCTGGTGGGATCTCCCACAAACCCAACTAAACTGAGTATAGCATAGGACGGAACCAGCAAACAAGAGCGTTCGTTTGTCATAGTTTCGATACAAGCAAATAATTGACTATTTTCAGACACCCCAACGCCTTTTCCTGTGTTTAAGGTCGAACATATGGTTGACCTGTATCAACTCGTAGTTTTCACCGCTAGTATAATGATCATCAGCTTAGGAAAACCAAGGCAGCAACAATCGCAGAGGCGTTCACTAGATCGTTTGCAGGCCGATAAAAACGTCATAAATGTTTTTCGAGGGCATGCTCATAATCGTTTTTGACCCTGAGAGTCCTTGGATGCGTTTTCCCTAGATGCTGCTCGTAAATGGCGAGGACGCGTTGATAGAGTGCATCAGCCTGTTTATTTTTGCCCTGCCTCTGATAGAGGAGCGCAAGACTGTGTAGAGCCAGGCCCGTGGCGGGATGGTCTGGTCCTGAAAGTCGTTCGCGGGTAGCTACAGCCTGCTGTAACAGCGGTTCGGCCTTGCTATAACTTCCTTCGCCTCGATAGAGAATCGCCAGATGTCCAAAACACTGGGCAGTACTCTGGTGGCCTGAACCCAGGTGCCGCTCGCGGATGGCTAGTGCTCGTTGGAACAACGTTTCAGCCAGATCGTAGTTTCCCAATGTTTGGTAGAAAATTCCCAACGATATTATGCCCGCTGAGGTGCTCAGATTTTCCGGACCCAGGTGTTTTTCATAAATTGCTAGCGATCTATGTAAATAAATCCCGGCCTGTTCGTATTTGCCCTGGTACCTGTAGAGTTCAGCCAGATTATCGAGCACAGCCGTCAGTTAAAGCTCATCAGTTCCACTCGTCGACTCTGTAAGTGTAAGTAACCGCTCTAGCAAAAGCACAGCCTCATCATAGCGCCCACGCTCCAGGAGATAGCCACCCATTTTTTGTAGCAAGGACCTTGCCTCCGGGCGATTCATACCTGTTTGTTCGATCAGCAGCCGACAGGCCTGAACGTGGGGAGCGCATTGCTCCCAGCTAACCCAGTTTGAGTTTTTTTCGTTCTCAATACATATTGCGTTTACAGCAACTACTGCCCGTTCTGTCCATTAATATTCCGTTGCCTGATTCATACCAGCACGCAATACGACCTGTACCAGGCGATGTGTCGAGAGGGTATGATCTTTTGCATTGCGGCTGAGCAGCGAATACGCAGAAATCGTACGCAAAGCCTTGTTTAATTGCAAAGGGTCAGCCGCCACAGGTCCAAGTGCTTCCCCAGGTAAGGTGCTCCCTTGACGATGATCTCTTCAGGGATAGCATCGGGATGCAAAAATGCACAGAGCCTCAGTAAATCGGCAGCAGCGACATTGGTTTGCTCAACCTTCTCAAAGGAGAGACCAGGTGGTAACAACCGAAGCAGGGTGGTCAAGGATAGTTTCTCCTCACCATTTCAGTAACTCCGCTTGCCTGGTTTCGTAAAGATGTATATAATCCGTCAAACTGCATGGCGTTTCCTCGATGTACGCACCTACCTGATCGAGTGCCAGGGGTAGACCGCCCATCATTGTCATTTATCAGATAAAATTTACTGTTCTCAGAAAACGAGCCATGCTGCCAAGCGCTTTCAGCGCATCAGCTTTCTCACAGAACTTGGCGTAGCGTCGCCTCTCATTCTTTTTCAGCTCTTCCCTTCTCTCCTTCATAAAATCTTGCCACATTTTTGCCACCATATCTGAGAAATACGCCAACACATGGGGAAAAATGGTCGCATTTCTGGCGCATCTCAGGTATACTTGCACGTGAGAAGGAGACATGCGATTCTAGCACAACGCAAGGGAAAACGGTCATGAAAGTGAGAGGTTCTCTTGATTCCGAAACGAGAAGCAGGAGGCCTTGATGAAGCATCATCGCCCCGTCAGAGGGGCATTAGGGGTCTTCTGGCTGTTCTGGGTGGCACTGGTTCTCAGTGGCTGCGCGACTGCCTTGTCGCAGGCGCGTTCGACGCCAACTGCGCCCTCGCCACGATCAGCATCTTCGCCTTGGGCTCCTCCTCCCTGTCAAACCCAGCACCTCCTGCTCGCTTTTGGCACCTTCGACGCCGCTACCAGCAACGAGGCCGCACAGTTTGTCCTGGTGAACCAGTCGAAGCAGAGTTGTCCGCTCTCCGGCTATCCAGCGGTCCAGCTCCTTGATGCTCGACACCAGCCCATCCGAGCACACGTCAGGCAAGTCACGCAGGGGTTTCTGTATCTCCCGCAGGTGCCCCATCAGTTTGTCCTTCAGGCGGGGGGAAAGGCGTATTTCGTGGTCTCCTGGGCCAACTTGGGCTGTGGGAAGCTCCCTCCAGGTGTAGGCCCTCCAGGATCCTTTGCTTCCCCAGTCTCCTTTCTGCGAGTCACCCCGCCTCTCAATCAGGCATCCCTGCTGATCGCCACCCAGTGGGGGGCCCGTTCTGTCCGTTCAGAAACTCTGTGGACATCTCTCCTCTGGAGCCGTACAATATCTTGCAGCAGCCTCGATGATCTCCAAGCTGAAGCCGCGTACTTCCGCGAAGCCAGCCACTGCGTGCGCGCGTTTCATGGAGCAGTGAGGGAACTGCGTGAGCGATCAGCTCTCCTTTTGAGAGGGGAGCCACGAGACGCGAGAGAGCCGATTTTTGCTCACGCAGTTCCCAAATGAACACTTCGGCATCAAAGCAGAGACCAGTTCGTTTGGCTTTTCAGCTTTGCGCCCGCGTTCTGCTTGCATAAAATCGTGCAGCCTCCTCGCGCTGCTTCTGGGAGTGACGCGCCAGATGATGAGAGAGACACTGGTCATTTCATCAGAGCTTCACAGCGCGGAAGAGATGAGATAAGATGTCGCGCCAACTAATACGAGAGACCAATGTGCTGAATGCACCTCTCAAGCCGATATGGGCAAGTTATCTGAGAGAAACGCGCCAGGAATTGAGTCTGGCACACTCTCGGTGATTGAGGCCGTTTGCTTCCTGTGATATGATCATTTCCACCAACCGTAGAACTCCCCATGCAACCCTATTTGATGAGGCTGGTCGATCTTACTGTTCCAGCAAAAGGATGACGTCATGAAGCGAATTCTGTTGACGGGAATGTCTGGAACCGGCAAGTCCACGGTCATTCGCGAACTTGCTGCTCGCGGATACAAGGCCGTGGATGCCGATAGCGACGAGTTCTCCCAGTGGGTGGAGATCGAAGGCGAAGCTTCTGCCGAAGTCACGCCGGTGGACGGAAACAGAGATTGGGTATGGCGAGAGGACTGCATCCAAGATCTTTTGTCCACGGAGGACACCGATGTGCTGTTTGTCAGCGGGTATGCGGAGAATATGCCGACGTTTTTTCCCCAGTTCGATCTCATCGTCCTGCTGAGCGCACCAGCTTCGGTCATCGTCGAACGATTGCGCACCAGAACCACCAATCAGTACGGCAAGCGGTCCGAGGAGGTCGCTCGCGTGCTGAGTTTAGTGGAAAGCATCGAGCCGAGGCTCAGATGCGCTGCGGGATACGAGATCGATACCAGAATCCCGCTTTCGGAGGTCGTGGCGACCCTGCTTCAACTGGTGCAATCACAGCCATGATGCCTGATCTTGTGCAGGCATGGGCCGGGGAAGGATTGGGTTGCGCGTCCAATGGGGAGGAATCACCTCAACCACTCGGATTGGTTGAATCCCAAAATTTACACCTGGTTGAGATTTTTACACTATCCCATTCCCTGAGTTTTCCTCGTTGCGCATTTCGTGGGACTAACAAATTCAATGTGAGGAGAATAGCATGCAAGTCCGTACAATCGGTGTGATAGGAGCAGGCGTGATGGGCATTGGTGTAGCCCAGGTTCTGGCGCAGCATCTACTTGTGCTCCCCAAAGGCACAGGGACACTCTTCGGAAACAAAGAATCGCAGAAGCTTGTGCTATATGGGCCAAAGGTATAAATGAGTGATCTCATACCACCAGGCAATTGTCTTGGAACATACTACCACAGGTACAGCTTTCCACACCCGACTTTCCAGGAATATCTGACTGCTCGCTATATTGCCGCACAGCCCAATCCCGACTACATCGACATGGTGATGGCACACCTGCATGAGGACTGGTGGCAGGAGGTACATCTTCTCACGATTGCTCACTTGGGATCGGGGAAAAGTGGAAACGCCTGCGACAGTGACACGCAGTTGTGGTGGTCCCCACCAGGCATTACAGGCGAGTCGGTCGAGCCAACTCCAGTGATAACGCGAACACGTGGTAGAGGGAAAACCTTCTCAGGATGCCTACTGCACCGCAGGAACAACCGATCTCTGAGATTTATGCACCAGTTGTCATAGCGCCCAAAAAACACAATAGAATTGTGTATCTCTTGCTGTATAATTACTTTAGCTTCGATTTTCTCCTTTGCGTTTCTTTTCGAGTATCTCACTGGAAAAGGATGGAGAAGGGAAAGAAAGTCGAAGTCAAACGTCATGAAGCGACCCGGGCACATTTAGCTAGAAAGAGGAGATCCCTGTATGACTGAAAATGATTTCGAGCTGGATATTCAGCTTTCTTCTGAGGAAACAGAGGAGCAAGACGCGAATATTCCTGATGCCTATACTTGGGGCAATACCTGCACAGGGCATTACCTGTGTACTACAGAACCGTGCGAATGCGGGGCGTTGCCGCCAAACAATTGAATAGGCGGTGAACCCTCATGGCATCTTGGCGCAACGTTCTTAATCCATCTTTGGCGGCAGCAGCAGTTGCTGCTGCCAAAGATGTGGCATTTCGCTTGCAGGACCCGGAACTGCTTCAGAGAGCGATCAACAACATAAGACAGCAAACCCAGACATCCGTGTACGATACAGATCCTGCTGCTTCCTGTTACGCGGGCCACGCTGGTGCAGCACTGCTCTTCTCAGAACTGGATCGTCGCTTTCCAACAGAGGGATGGGATGTCGCTGGTCACCATTGTATGCAAGTTGCGGTATGCAGCGTCAAAAGGTCGTCCTGGTCGCCTCGACGGCTTGGGCTTGGCGCTCTTAGCGGCCTTTTGTTCGTCACCTGGTCATTAAGTCATGGGGAAACGCGCTATCTAAGGACATTGACTGCCTTAGAACAGCAAGCGTTACCAGCAATCCGCACTGTGGCAGAAAACGTTATTGCTGACCAGGTCCATGGGTGTACAGAATCGCTTTACGATCACATTAGCGGGCTTACAGGAATGGGAGTGCACCTGCTTTGCCGCCGTCATGTTCCAGCGGTAACCGAAACACTGGAAGCAGTGCTTCAGGCACTGATCTACCTGGCAGAAGAAACTGACGGGATTCCTCATTGGTATATCCCTTCTTACTTGTCAGATCCTGGCTGGCTCAGCAAATTTCCTCATGGTCATCTCAATTGTGGATTGGCACACGGAATCCCTGGGCCTCTGGCTCTACTCTCTCTTGCCAAATCCAGTGGGATACACGTGCCGTCTCTGGATATGACCATTCGCCGGATAGCAGATTGGGTAGTCGCTCATCATCGGGCAGATACCTGGGGCATCGATTGGCCCAACGCGTCCCCACCAGGAGACGCTCCGGTTGAAAGCGGAACTACACGCACGGCATGGTGCTATGGCATTCCTGGTGTAGCTCGTGCCCTCTGGCTGGCAGGGAAGGCAGTAGATTGCACGACCTATCGAGACGTTGCGTTGCTCGGAATGCGCAGTGTCTATCGACGATCAGTCGAGGCTCGTCGTCTTGATCCATCTGGCTTTTGTCACGGTATTGCTGGTCTTTTGCAGATTACCTTGCGCTTCGCTGCTGAGACAGGAGATACTTGTTTTATTGAGCCTGTAAATACCTTATGCGAGCAAATGCTTGCCAACTACGAACCCGAGACACTGCTAGGATATCGAGCACGGCGAATAGGAGGAGATCTGCTTGATGATCCCGGCCTGTTAAACGGAGCCGCTGGCAATGCACTGGTGCTTTTGGCCGCCTCCACTCCCCATGAGCCAACCTGGGATCGCTTTTTCCTTCTCTCGTAAGTTTTGTATGTAAGAAAGCTAACTCGTATATGCATTCATCAACTCGAACATTTTCGCCAACTGAGTTATTGACATCGCACGCAGTCCGCTATACTCCGTTGGATTTTATTCAGGTCCGAGCGCCTCTTTTTCCGATTGAAGCCTACCTTTCCCTCCAACAGCCGTCAGCGGTCGCAGCCTCCGGCTTACATCCCCAAAACCCACTTGTGCGGCGAGCCCTGGCAATCGGCAGCATTGATTTCTTGGAAGAACTGGACCGTCAAGCATCCTCTCCACGCGACAGAGATCGCTGGGAACGTAAATTGCTCCGCTACCTGATTCGCATGGCAACGCGCCCGACTCCCTATGGATTGTTCGCCGGTGTTTCCCTGGCGCGTTGGGGAGAGCAGACCAATGTGCAGATTGCCAACCGCCCTCGCATACTCTTTTCTCGCCCGGATTTGAACTGGCTCCTGCCCTTGCTCTGGGAGCTAGAAACTCTCCCAGAGATACGCCGTCATCTGCATTATCTTGCCAACCGGGCTGCGTTTGTACGCAATGGTCGCATCTTTCTGCAGGAACAGCTTGCACTGGGTCAACCCAATCAGAACGAAACTGTCTCGCTACGGGCTACTCCAGTTGCGCTGCTCACGCTCAAACTAGCCCGCCAGCCTATCTCCCACAGTGATCTGGTGCAAGAACTGTTGGCTGCCGTCCCTAGAGCTACGCTCTCCCAGGTGGAAGAGTTGATCACGTCACTCTGGCAGTATACCTTGCTCTTCACTGATCTGCATCCTCCCTTCACCGGGCAGACCTTGCCTGCCCAATACGTGGTACAACGTCTGGAGAACATTCCATTTGCTGCCCCTGTCGCTACGCTTCTGCAGAACTTTTTACGCGCTTTAAGGGTATGGGACCAAACGAACGACGAGGAAAGTATCGAACGCTATCATGACTTGCAGTATTGCGCTCAGGAGATTAACACAAAGGTAGAGACATTACGTTGTGCAAGCCAGCCAACCTACCTCCGTCAAGTGAAGCAGAACTGGGCGCACTTTCCATCCAGCACCTTCGTGCAAACCGATAGCTCCTTTTCTCTGGTTGGCCAACAACTCGCTCGGAAAATTGGTCAAGAGATCGAGAACGTTGCGCCACGGCTACTACGCCCGCAGCGTCCCCACTACTTGCAGGCGTATCGCATGGCCTTTCTCGAACGCTATGGTACTGATCGTGAGGTACCCTTGTTGGAGGTAATGGACTCCCAGATTGGCCTGGGAGTTCCTGCGTTTGCACTGAAAAGCGTCTCGGATGAGATGGGCAAACAGAGCGAACGCGATCAAGAATTATCTCGCCTGGCTCTGATGGCGTTGCATGAACGGCAAGGAGTGATTGCGCTCGATGAAGAGAGCTTGCAACGTCTGGCATTGGTTCCTCCTAGCGATAAGGTTCGACTACCGCTCTCGTTTGACCTTTTTGTCTGGCTGGCGGCAACCTCACGCCAGGCTCTAGCAGAGGAGAAATACCAGATCGTCATTGGGCCACATGGGACCTATCAGGCAGGTCAAAGCCTGGGTCGTTTCGCCTCTTACCTTGGTACAGAGGCTGTACAGGTGTTAGAACACAGCGCGCAACAGGAAGCGGAACGAGAGCCCCACGTTCTCCAGGCAGAGTTGGTCTATACCTCCTCTACTCCTCGTTCGATGAATGTCGCACTTCGGCCCGCAATTCGCAGATACGAGGTGATCTATGGTGTTGTACCTGGCGTGAGCATGGCAGACACGATACCCCTCGATGAACTTGTTCTAGGGGTGCAAGGGGAGCGCTTTTATCTGTACTGGCCCAGGCAACAGATGGAAGTGCGTCCATGCTCTAGTCATTTGTTGCAGTCAAGAACTGCTCCATCGATCATGCGGTTCCTTTCTGACCTCAGTTTGGATGGCACATACAATCTTTCTCCGTTCCATTGGGGAAGATGCGTCCATTTTCCTTTTCTTCCACGCCTCCAGATCGGACGCGTGGTTCTCTCGCTCGCTCAGTGGTCGCTTAGTGCATCTTTTCATGAGAATGAACTGTGTTTAGCGTCACCCGAACAATTCCAGGAAACCCTCTCCTGCTGGAGAGAACGTTGGCGAGTACCCCGTTATGTCTATCTTGCTGAAGGTGACAATCGCCTGCTGCTCGACCTGGAACAGGTCGCTCAGGCCGAGGAGCTTCGATCCACGTTGCGAGCACGCAAAAAGACGCAGACGGTGATGCTGCAGGAAGCGCTCCCGGGACCTGAACATGCCTGGTTAGAGGGACCCGATGGACATTATCTTTCAGAATTTGTCGTGCCACTCATAAGGTGCTCATCTACACCATCGAGGGAGAGACTCGTTGCACACTCCCCTCTCCCGAGCAAACAAATAGCAATCGTGAATGCAGAGCGCCTGAAAGCACCTGGCAGTGACTGGCTATTTCTCAAACTGTACAGTGCACCGACACTGCATGAAGAGCTCATTGCCGATCCCTTACGTACTCTCGTGCAAAAGGTCTTTACGCAGAAGCTGGCTGAGTCATGGTTTTTCATTCGCTACACTGATCCTGATCCTCATCTTCGTCTGCGCTTCCGGGGCAATCCCTCTCTTTTGACATCACAGCTCTTTCAAACGTTGTGTAGTTGGGCCTCTCAATTAGTCTCTGATGGGAGGTGCCTCAAATTCGCGTTTGATAGCTATGAGCGAGAAATCGAGCGTTACGGTGGTCTAGAGGGTATGGCTCTAGCCGAAAAGCTCTTTGATGCGGACAGCAGTGCAGTGATAGAACTGCTACACCTGAAACGGGCTCGCAGGCTGACACTAGCTCCCCAGATGTTGGCAGTTCTGACCACTGATGATTTACTGGCAAGCCTGGAACTGTCTCCCCAAGAACGTCTGCACTGGTACCGTCAATCCCTTTTCAATACGAAAGAGGTTGGGATGACCTATCGTCTGAAAAGTGCGGAGTTACGTGCTTTGCTGAAAGATACGCATTATATACAAAAGCTGGAGGGAGGGATGCAACTGCTGAAAATTCTGAATACGCGGCGTATTTGCATCTCTCAGATAGCACAACAGCTTTCGGATCTCGAGACGCAACAGGGTTTGATGCAGCCGTTGAGCCGGATGTATGCCAGCTTTACACACATGCACTATAATCGGTTGCAGGGTATCAATCGCCAGAGAGAACGGGATATCTCAGAGTTAGCACTGCGGACCTGGATGGGCCTTTTAGGAGATCCTCGCACAACATAACTGAGGTGCCTTTATCGATGATAGCGAGCGTTTCCATCACCTGCTGCTTTGGCTAGAGCCATCAGCGGAGTGATATTTTCCAAAGTCAAGGCCTCTCCTGTGTCTTGATTGTGCTGTATGCAGCGGTTGAGCGGTTTAGACCCCCGAAGAAACAAGCAGAGCATTCTGTCCCGAAGCCGCCCCAAAGAGGAAAGGGGCTTGTTCTTCAGCTCAAAGCGAGGTATGCTCTGAGAGAAACACTTGCGATGCAGGAGGATGGTATGCAGAAAACAGCAAGCATGCAACGCAGCTCAAGATCCGTTTGCCTCGGGGAACTCCTCTTTGGTGGGGTGATGCTTCCTCTGGAAAATCTCCTTTGTCACCTTACCGTCGAGGTTACGCATCGTACTTAACAACTCTACCAGAGCATGGATAGGATTCTGGACTGCGCCTCCATACATACTACCAGAATGTAAATCTGTCCCGGCGCCTTTGACGTTAATCTGGAACGCCACCAATCCACGTAAGCCATAACACACAGCAGGCTGGTTGGGTCCCAATATAGCCGTATCTGAAATGACAACCACATCTGCAGCAAAACGTGCTTGTTGCTGTTGTAACACTTGTGTGACATGTTCACTCCCAATCTCTTCCTCTCCCTCTATACAGAATTTTACATTGACCGGCAGGTTGCTGGCAGTAGCAAATATTACTTCAAATGATTTTATATGCATAAAAACTTGATTTTTATCATCGCTTGCGCCACGCGCATAAAGTTGACCATCGCGGATTGTTGGTTCAAATGGTGGGCTCTCCCAGAGTTCAAGCGGCTCAACCGGTTGTACGTCATAATGTACATAGACCAGGACAGTTGGCTTTCCAGGCGCATGCAACCCATCAGCATATACGATAGGGTGACCGCGAGTTTCGAGAAGCTGCACATGCTCAAAACTGGTATCACGTAAGTGCTCGGCTACCCATCCAGCACACCGGTGTATATCATCTTTAAACTCGTTAAGCGTGTTTATACTAGGAATAGTCAAAAATTGCTTGAGCTGTTCAAGGTGCAATGTGTGTTTCACAGAGAGATAGTGGTCGAGGGATTCGATCATGACAGAGACCCCTTTTGCTTGTAGTAACTCGATGTTATCTATATATTCAGCGCTTCAGATTTGGCACCTTCCAAGAGCTTCCGTCTTCAATAGAAGCCTCCCATCCTTCAGGAAGAGCGTATCATCTACCCATACTTCTCCCTCAAGGCGTAGGTCACAGATAATATCCCAGTGAATGGCTGAACGATTGACTACGCCCGCCTCAGGAAAGCTGTCACCCAGAGCTAGATGCACAGTTCCTCCCATCTTCTCATCAAAGAGGGTATTATGGATGACTCGCATGACGCGTGGATTGTTACCAAAGGCAAATTCACCCAGGTAGCGCGCGCCCTCATCTAAAGACAGCATCCTTTCCAGATATTATTGTCCCGGTGTTGCGCTGGCCTCGATAACTCTGCCACGCTGAAAAACCAGTCGAATCCCTTCAACCAGGTGCCCGTATACCAGAGACGGGATATCAAAGTGGATGATGCCAGTGGTACTTTGATCCAATGGACTTGTATAGAATTCCCCACTGGGAAAGTTGCGTCTGCCGTCACCATTCACAAATCTACGTCCCTCAATAGAGAGAGTAAGGTCGGTTCCTCCACTGAGTATATGTACTTGCTTGCGGCCTGCGAGCCAATCTATCAATCGCTGTTGCTCTGTACCCAGTTTCTGCCAACATTGTATAGGATTGTGATCGTTGAGGAAACACGCATCAAAGGCAAACTCTTCAAGATCATTCAGAGACATATTGGCATTCTGAGCTAGAGCATTGGTAGGGTAGCGCGTCAACGTCCAGCGCGCCTGTTTGCGACGAGCGTAGATATTGTCTGTTGCCTCTCTTCTCAGCAGAATGCGTGCCGGATTAACCGCATTCAATCCGCTCGAATTCTCCTCTGCGCGGATCACCAGCAGAGCATCGACCTCTTCTGCTATCACTTCCTGTAGACGTGTCGACTGACATATCTGTTCATTATTCCCATCACGCAGTAGGATTTCGTCTAAGCGCTCCAGTGACAACAGCACTATTGGAGATGCGCCTGCCCTTATTATTTCTTGATAGACTGCCTCAATCAGAGGTGCAGTCAAAGGGCACGACTCAATACCTACCCTCTCTCCTTGTTGGACTGAGAGACAATAGCGTACTAATGTATTGAGCCCATCGTACAACACGGGGATCTTGCATACTTAGTGCTCCTTATCCAGATGAGCATAGGACTACTCCTTGACTATCGTACCATAAGGCACCTCTTTCGGATCGGGCGAAATACATCGCCGAGTGAGATTGTGATCCCTCCAATAATCAGGGTTATAAATAGTCCTAAAGTAACGATCCCCCCTATCGGGAAAGATCACGGCTATTGTGCTCTCCAGAGGCATTTGAGTACTGAGCCAACAGGCGACCAAATAGGCAGAGCCAGAAGAATTTCCTGCAAAAATCTGCTCGCTTGCAGCCAATTGTAGAGTAGCATTAAATGCCTCCTCATCATTTAACCAATGTACTTGATCTATCAGCGTTTTATCAACATTTTCGGAGATTATACTATTTCCCAGTCCACTCTGAAGCCTATTTTTTAGATCAGGTTGATCAAAAGTGATGCTGCCCACGGCATCTACACCTACAACGAGCAGGTCAGGTAAGAATTTTCTTAAGAAACGAGCGGAGCCACAGAGTGATCCACCACTTCCTACAGGTCCAACCAGGGCATCTATGTGATTTACATCCTCAAGCAACTCTTTTGCAAGTTGCGTGTATGATAGAGGATTTTGAATACTGGTAAATTGTCTCGGCCAGAAAGCACCTGGATGCTCCTCCATTAATTGAAGAACCTTCTGGCGTCTTGTCCCTTGCCAGCCGCCCTCTGTCATCTGCTCGACCATATGTACGATAGCACCCAGTGTTCGAAGCTTTGCCAGGGTGAGAGCATCGACACGGGGATCGAGCACAATATGTACCTCATGTCGAAGAGTGCGCCCAACGAGAGCCAATCCAATCGCCAAAGTACCAGACGAACTTTCTATAATAATGCCGTCATCTTTGAGTTCACCGTTCTCCTTAGCTGCCAAGATACTATTGAGAGCAACACGGTCCTTCATTCCAAAGGGATGTATCAGAGCACAAAGTTCTTCAGAAGAATTACCATCCGCTCCATCGAGACGGGCTAAATTGCCAAGAAGCCGCTCTCGCCAGCCGCGTCGCACAGAAACAGCACATAGTCCAGATATCTACCGTGCATCTTCGGCCAATTCCTCTGCTGCAGTTTTCACGAATCTTCCTGGAGGGCACTGCACCAACCAGCAGACAACCTCAACAGGGAAGTGGAATGCGAAGCTGTATGCGCAAGCCTCTTTATGGTGACGATATGGGCATATCTTCTTTTATAGAACTCAGCGCGCCTGAGGCCCTTTACATTCTATTGTGGTAGAAAACATATTTGAACATGACATGGGATTATGCGTAAACATAAACCGGAATTATTTATACACCTATTTTGTCTCCTCTCAAAATACGCTATGAGAGGATGGAAGCGAGATGGTAAACGATAGAGCCATAAAAGTTTTTTATTTTTGTGTACCTGCAGATGAACTGTACTGTCAAAGACTAGAAATGAATTTGGTGATATTGAAGCGCCATGGGGCGATTCAATCTTGGGCGAGCAATATCACCACAGATCCGTCAAATCTCATTGATGAGCTCAAAACGGTTGATATAGTCCTCTTTCTCATCAGCCCAGATTTTCTCGCAGCCGATCACAATTTCCGTGCCGATTTCCAGATCATTCTTGAACATCAGAATGATCGCAGAATCTATGCGGTTCCACTGCTCGTACGTCCCGTATATATGGAAGGCAGTCCTTTTAGCTATATAGAATCCTTGCCAACTGGTAGCAAGCCCATAGCAAAATGGAAGAATGAAGACGAAGCTTGGGTGAATGTCTCTTGGGGCATCAGCAAGATCGCTTCTCATTTACAAGCCATGCGGCGATACGAGAGAAGTCATCCAAGCCTTGCTCCAGCTCCAATCGATCCTTTTACTGTAGCAGCTGCAGGTACTGCGATAGCTCAGGTAATACTCATGGTAAGTGACATGTGGTCGAGAAGGGAGAGAAAGGGAGAGGAACACAAACAGGACGAGGTGAAAGAAGTTCGTGTCCTCACCGGGAGTGGCCAGTGGGTACATTTCCGTAGTACGGAACAAGCAGGTGGAGCATGGAATCAGGTACAGAAAGTTCGTGCATTAATGAGCGATAATCATTGGATAGAGCTGCAAACTGAGGACGAATTACAGTACAGGAGCAGTACTACGACTCCTGCTAAGGTCAGAGTCAGAGCGGTAAAGTAGGCAAGGGACTAACCGACATAGCCAACTCCACCCATGAGGACAAGCCCCAGAAGAGCGGGACCACGAGGAAAAGGAATGCTGCGCACACGCATCACACCTACCATGATGAGAGCAGCGAGAGCGAAGCGAAGAAGCAGCACTGTGGTAGGAGTGGCCCCTGCTGCATAGGCCAGACGTGCGAAGATCGGCAACGTGCCAAACGAGATAGCCGGGATGCCGGTGAGGAGCGAGCTGATCCAACGGCTGGTAGTTCCAGTGTTCGTGCCATGCATCAATTCATCCTCAACGCTCGATGTAACCTGGCCGCCCGTGGGTGGCAACAGGCGTGGTGGGCAAATATGAGAACGCGGAGGGAACACTTAGGTGTTCCCTTCCTTCCGCATCCGCCTGTGTTCTGCAGCAAGTGTGGCATAGGCCGTGGCCCCATAAAGGATACGCCGGTGATCGGCTTCGGTGAGAGGCCGTACCACCCTGGCAGGAATTCCCAGAACCAGCACACCTGAGGGGATAGTCGCACGTTCGCTCACGAGAGCCGACGCCCCAATCAGGGTGTCAGAGCTAATCTGTGCATAGGAGAGGACAACGGCATGCATGCCGACCAGGACATGGTTGCCGATGGTTGCCGCATGCACAATAGCATTATGGCCGATGGAGCATTCCTCTCCAATCGAGAGGGGGCCATTAGCCTCAACATGCAGTGTGCAGTTGTCCTGAATATTGGTCCCACGTCCAATGCTGATAGGAGACAGATCCGCACGAATCACCGTATTGTACCACACGCTGGCTCCTTCATGCAATATCACGTTGCCAATAATCATGGCGCCGGGAGCAATGAAGACGTTGTCAGCGAGAGTCGGCCAGATTCCCTGAAAGGGAAAGAGGGGCATATGTTGCTCCAATCTGTTTGAGAACGAGATACTACTAAAGGAATGATACACCAGAAAACAGCGAAAGTACATGGCAACTTGAAGGAAATGGTGCCATTCTACCTTGAGATTTAATGGAAAGCATCAGGAAAGATCTCCATTGTCCATCTTTTCCGGTCTTCTGCTGCCTACACCCTTGCCAGAGGATGCGTACAGAAAAAAACCAAGAACGGCAATCATGTCTGGAGCAAGCGAGCTTCAATGGCAGCAAGATAAGCCGTGGGATCTTTTCGGAAGCGATATTGCTTGCGACGAGTTTCCTCCCGATACGAGAGGTGTTCGCGTAAATGCCGCCAGGCTTGATAATCGTAGGGATGGAGTTCAAGCACTGCTCAAAGAATGGAGCCGCGTAGCAACTGTTGTGAGCACACGCACCGACCCGCGAACCACCACGCCGAGGATCGCTCCACGCCGCCCGGTCGCTCGCCGCTCATGCTATCGTGCTGAGGCAAAGCACTGTTCGAGCGCGTTGTTGGTGGCGGGCAGGTCAGCGATGTCGTAACAGTGGAAGAGTCCAGGAGCAAAGCTCTCGGTGATCTTACGAAAATGATCAACCGCTTTGCTAAGGTTGCCAATCTGGCTCTTGTGGCTATCCATCTGTCCCAGCAACTGCTCATACTAAGCACAGACCTCTTTTCCAGCAAGCTTCTCATGATTGGCAAGGACATGAGCCGCCTGCTGGACCCACTCATAAGCGACCTGAAGAGGAGGCCACAGAGAGGAGGTAGCTGCCAGAGCGAGTGTAAGCAGGTGATGCAACTGCTTTAAGGACAGATGGAGTCGCCCTTTTTTCTGCTACGCGGGCAATCGGATCGTTGATATGTGTCAGCCACTCATGGAGCTTGAGTCCAGAAGCACAGACAGGGGGGCGTCCGTTATCAGTCAAGGCACTGCGCACGGCCAAACAATAATCGCGAATGGTCTCCGTTTCGGCATCACGGCCCTCTTCTCATGCCCGCTCGATTGGACGATTGCCTCGCACGTGCTTTTTCAACTCCGTCTTGGCATGTCGGTCGGCTTCAAAAATGAGCATGGCTGCATCATGGAGGTAATGAAGCTGGCAGAGTTGATGGGGGATTTGGGAAAACACGAAGGCCACGGCTGACCGGATCGTCTCCTGTCCATCCGAAATCACTCCTTTTACTGGAACCGGCAACTGGTTCTTTACTTCCATGAGCAAAGCGCTGAGATCACCCTGGGTTCCACTGAGCAGTGCACGCGCTAAGAGGATTTTGCCAGAGAGACAATCACGAATGAGTCCCGTGCACTTCGTGCCCGACATAGGATTGGTGTAAATCGAGAATATAGATGAGGGTGAAATTGCGGAGCCAAGTGAGTGGTAGGATGTAATAAAATAGGTAAAAGAGGAAATAAATAGAAGAAGGTGTATCGAAACAGCGCGTTCCCTCAGAGATCGCCAAAGAAAGCGCCTCAAGGAAAGAGCGAAACTGGACTCAAAAGAGCGAGGAAAAAGGGGGTGGAAAAGAGAAAGGCGGATGGAATGCGAGATGCCTGCGGATGAGGAGGGACCGCTTGCCCTGGGAAGCGTGGTGTGGAGCGCACTCGTCAGGTCTTCAAGAAGCGTGTTTTGCTGCGCTTGTCGGATGTACTCTTTGAGCTTTTCATCCAATTGCCGATGCAAGACCTCCTGCATCTGAGCGTGGTTAATAGCTTGAAAGTAATGTTCATACGCTTTCAACGTCTCAGGGCTTCGCCAGGCCATGTAACGGACCATTTCCTCCTTGCGGCGTTCCACTTCTCCTGGAGTCTCGGCAATCCCATGAATCAGTCGCATCATTTGGCAAACATGCCAGTGGCGAAGCCCATGGATATTGAGGTCAACGCCAATCGTTCGGCGCAACCGTTCCCAATGAGGGACGAAAGCATCATAGCTGTAAGGTTTGTGCCTGGCCAACAGGAACAATGGCTCGTGGTCACGTAACTGAGCGAGAGTACGATGGTGCGGATCGACACGAACACGATCTTCGTTCACATAGCGATGCAGGAGCTTCGCCGTTTCCATGCTAAAGCGAATGATTTTCACCCGTCGCCCGTGGCTCTCTTTGTTACAGGCCGTGGCTTCCTGTTTCCCACCGCGCTTTCGCCAATCGCCTACTGTGAGGGTGAGCAATTCAGTGATTCGCGCACCAGCTTCGTAGGCCGTGCGTATGACGATCTGGTCACGCCTCGTTACCTTGGCTTGCTCGAACCCTCCAATGAGTCGGAGGTGCAGAGCGGGGTCATCAATGGGTTTTGGAATCTACTTGTCGTCTACCAAACGAAAGTAGTTGTCCGAGGTTCGCTCTTGCTCCCCTCGGTAACATTCTTATTTGAGGGAAGTGTACCTTGTTCAGTAACATTTTACCTGAGGGAATGCGAGGGCTTGATTTTTGGCAGGAAATAGTGTATACTTGATTGTGTTAGTTACAAGAGAGCCATTGATTGGTTCTCTTTTTTTGTGCTCAAAGGCTTCATGCTCCTCCTCTCTCTTGCCCCGCTTTAGGAGCGCGGTCAGAGGGTTGTCCACAGTCGATCCACCGTCGAGGTGAGTTCTCCACACCTTTATCCCCATTTTTAGAGCGAAATTGGTGGATAAAGGGATTGCCACCCTCTCCCTTCTTCAGGTACACTTGTTCTTATCAAGAGACTTCTCGCTCTCATCTCGTGCCTATTTCATCACTGGATTATCGTTCATTCGCACACAAACGAGAGGAGAAGTCGTATGGTTTGCCTTTACGGGACCCTTCCTCCCTTTCCAGGTGGAAAAGCCTTTATCCTCATGGCGCTTCAATGGACGCGAATGAAGCCGTGTCCGCATACGGCAGGCGGGCTTTCATCCGCCTTGAGGTTCAGCACGGTTCTCTCTGGTCACGCTTCGTGTGTTGTCTGCATCTCATAGGCTTCAAGAGGAGGAAGATCATGCCAGCCCTGGCCCCAAAAAGTGCTGTTCGGTATCGTCCAGTTGACCCGGATGTTGCCACCGAAGAGCCACCGCGCATTCCTCGTGCCTCACGCACCCAGCCAACCTCCAAGCTGCCAGAGCGAAGGCAGTGTCCTCTCTCTTGTCAGCCCCTCTGGCTCCTGCCTGTTGGTGTGGGCATGATCCTGATGCTCTTCATCGTCATCGCGGGATCAGTGGTGCTGGGATGGGTGCAGACGGCTTCAGACGATCTGCACTATGGCCGTCCTCGCACCTTCCAGATGGATGCCTTTGTGGGGCATGAAACCGGTAGCACCTCCAGCCACTTCATCGCGCTTAATTTGCAAGGAAAGATTGAGATCATTGAATTGCCTGGAGGTGATCCAACGCGAGCGAGAATGTATGTTGGGCCTAAAATCTATGGACCAGGAGCAGATCTGGTTCCAGTGACGTTGCGCTTCGTGGAAGGAGCCCAGCCTCATCATCCGGAGATGCTTATTCTCTTCCAGAACACGCAAGTGGTCTTTCGCAATGCCAATGGCACCTTTGCGCCTGCAACTCATACGTAGTGGGCGTGTCCTGCCAAAACCTCGTCATCCGGTGGCGTGCAGGGCTGCTGGCAGGGTAGCCTCTATGTGGAGAACGTCGCCGTCAAAACCCATCAGGAAGAAGGCTTGATTTTGGGGGAAAATCGGGTATAGTTGATTCTGTTAGCTACAAGAGAACCATTGAATGGTTCTCTTGTTTTTGTGTTCAAAAGTTTCGTTTTCTCCATTTCTCTCGCCCTCATATGATACCTTCACCCCGTGTCATTGGGGGAACGACAAATTATGTTCCCTCAATTAAGGAACCTCTATCAATTATTGGTACATCAGTCATTGTTCCCCCACACATCTACAATTCAGAGTAACAATGGCAATTGTTACTCTATCTGATCGAGAAACGAGGGAGAATATAGTCTTTATAGGAGGGCACATCAGGCTGTAAATCGACAAAATAGATGAGGGTAAAATTGGCGGGATAAGTGAGTGGTAAAAAAGAAGGGAAGAAGCAGAGAGTGAGAAATGGAGGAGAAGATGGAAGGAGCCAGGGGAAAGCCCTCAAAGAAGCTGTTCAAAGAAGCATCAGGGAAGGTGTGAAATAGGGGCAAAAAGCAGCGGAGAGGAATGGTGAAAAGGAGTCGTCACAGGTGGTGAAAACGGAGGAGGAGAGGGAGAGAGAGACATAGAGGGTATGGGGAAAGCGCGTGTGGAGCGTGCCGATAGGGATCTATCAAAGACTGTGCAAAAAAGAGCCTCAAAGAAAAGAAAGAAAAGGATAGCCCCATTTTTTTGCGAAATAGATGAGGGGAAATCTGGAGGAGAACATGAAGTGGCTGGGTAAAAGAGGTGATATATGGGGAAAGATGTAAATAAGATAGGTCTATCTGGTGAGAGAGGGAGACAAGAGCAGGAAAAGGAGAGGTCTCGGCATCTCTAAGAGAAGCTGGAGACCTCACTTTTTATGGAAAATTGATGGAAAAGGGAGAGGAATATACTGGCTCATGGGGTGAGAGGGAGGAGGAAACAACAGGGAGGGAGTATGAAGCAAGAGAGAAGAGTGCCGAGCCTCACGGAGTTGACGGAAGAGCAACGGACAGAGGCATATAGGCGCTATGAAGTGGTGAAAGAGTGTGTGGAAGAAGGAGTGCCGCAAACGGAGGTGGCGCGGGAATATGGAGTGCCGCTCTCGACATTGCAGCGCTGGGTGCATCAGTATCGGGAAGATGGGCTGTGTGGATTGGCCCGGCAACCGCGTGCGGATCGAGGGACGCGGCGCAATCTCTCGGAAGAGGTGGTGAAAGTGATCGAGGGATTGGCCTTACGCAAACCGCGCAGATCGATGGCAACGATCCATCGGCAGGTGAGTGCGATTGCGCTCACGCAGGGATGGGAAGAACCCAGCTATGCGCAGGTGTATCGAATCGTGAAAGCGTTGTCACCAGCGTTGGTGACGTTGGCGCAGGAGGGGGCCGGGAGCTATCGAGAGGAATATGAGCTGTTGTATCGGCGAGAAGCGGGAAGGGCCAACGAGATCTGGCAAGCGGATCATTGTCTGTTACCAATTTGGGTCAAAGATGGGCAGGGCAAGAGCGCTCGACCGTGGTTGACGGTGATCGAGGATGATAAGAGCCGAGCCATAGCTGGCTATCGGTTCTCGTGGTCAGCCCCCAGTGCGATCCAAACGGCACTAACACTCCGGCAGGCGATCTGGCGCAAAGAAGATCCACAGTGGCAGGTGTGTGGTATCCCCGAGGTGTTCTATACCGATCATGGGAGTGATTTTACGAGCGTGCATTTGGAGCAGGTGGGAGCGGATCTCAAGATGCAGTTGGTGTTTTCGCAGGTGGGAAGGCCGCGAGGGCGAGGCAAGATTGAGCGATTTTTTCAGAGTGTGGAACAACTCTTTTTAGAAAGACAGCCCGGCTATGCGCCATCGGAAGCGTGGCCGAAGTCTGTGGGGCAGGGAGCCGGGAAGGAGAGAGCAGGGGTGCTGACGCTCTGGGAGTTGGAGCAGTGCTTTCGGGAGTGGTTGCTCTCGGACTATCACCGTCGGGTGCAAAAAGGGCACAGCAGGGGACCGCAGGAGCGCTGGGAAGAAGGGGGATTGTTGCCGAGGATGCCGGAGTCGTTGGAACAGTTAGATCTGTTGTTGGTGCAGGTGGCAAGGAAGCGGCGGGTGCAACAGAGCGGGATTGCTTTTGAAGGATATACGTATCTGGATCCCACCCTCTCGGCCTATGTGGGGGAGGAGGTCATGATCCGGTATGATCCGATAGATCTCGCAGAGATCAGAGTGTTTTTTCAAAATCGGTTTGTCTGCCGGGCGATCTGTCCAGAATTGTCGGGACAAACAGTGAGTTTGAAGGAAATTGTGGCAGCCCGGCAGGCAAGGAGAAGGGATCTGAGAGGAGAACTAGCAGAGCGAAAAGCGTTAGTGAAGCACTATGTGAAACGCGAAGCCGAAACCAGCCGCAGGGCTACGGCAGAGCAAGCAGTGGGGGGAGAAAGCGGCAGCAGTGAAGCTGGAAGTTCGCCAGCCAAGATGCAGGAGCAAGAGGCCCCTGTGTCAACGAAAACGCGTCTGAAGAGGTATAGGAATGAGTAAGGCGAAGACGAAGGAGCTCATGGGGCCGGTTGCGAGAGAAGGAGTGGTGGTCTGGGAAGGGCTGGGTGAGGAGCAAGAGGAAGAAGAGGTGCATCGTCGGCTGTGGAAGCGGTTTGTGCAGACGAAAGAGTATGGGAGATTTGTAGAGTTCTGTGAGGAGTGCCGAGCCTCGCGCTATATCGGGGTGTGCTATGGAGCAGCAGGAGTAGGAAAAACCGAGTCGGCGAAGGAATATGCACGCTGGGATGAAATTGAGCCATTGTTGTCCTGGCATGGGGTGGTGCAGCCCCGGTTGTCGCCAGAGAATCCCAGGCCGACAGTCGCGCTCTATACGCCCACGGCGACGGTGACGGCCAGGCAAATAGAGAAAGACATTGCGCTGCTGCGCTGGAGTCTGCGGGTGATTGGAGAGGCGGCCCGCGCCGTGCCCCAAGAGGTGGAGACGGTGGAAGGGATGGTGCGTCCGGGGCAGGTAGACCTGTTAGTGGTGGATGAGGCAGATCGACTCAAACCACAAGCCGTGGAGGTGCTGCGAGATGTGTATGATCGAAGTCCCACGGGGCTAGTGTTGATCGGGATGCCTGGGCTGGAGAAACGTTTGGCCGCTATCCGCAACTGTATTCGCGGGTGGGTTTTGTCCATCAATATCGGACGTTGGGAAAAGAAGAACAGCAGGAGCTTGTTGAACAACAGGTGCGCTCTTTTGGCGGAGGAAGAGGTGAGGGAGGAAGATCGAGAAGGAGGCAGTGGCGCAGATTATTCGTATGACGGGCGGGAATTTTCGGCAGATGGAACGGTTGCTCTTGCAAATGAAACGGATCATCGAGATTAATCCAGAGGTCGAACAGGTGAACCGAGAAGTGGTAGAAGCAGCGCGAGAGCAGTTAGTGTTTGGAAGAGGTGTCTAAACCGAGAGCAGGAGGAGGCTCTCTTCTGGTTTGCCTTTTCAAGACAGAGAAAGAAAGCATGTGTTTTTCTCTGTCTGAGCATTGTTCAGAGATGCGTTAATGATGGCCCAGGATGCGCTTGCGAGTAGTGCGTTGCTGGACTTCTGTCGCTTCTCTTTCATCGATTTCATCTTGTACATGGCGTGGTTGGAGGGATTGTTTCTCGATGTGTAAATATTCAACCTGATCTTTCTCGTGATTGAACACGGCGATCCATGTGTATGTGCGCCCTTGACGTTTCACCACCGCCGGGGTGATTTCCGAGGGTGATTTTATCCAATAAACTTGCATGAGCATTTCTCCTTTCACTCTGTTCTACAGAAGGTTCCAGTCATTTTCCTGGTATCGCTTTTGCGTTGCGCACTTCTTATAGTCTTTTGGGAGAGAGAAAATTGGGGATCTGGAACTCACCACCGATCCATGCGTGGTTTTCGTGCCCGCTCTCCCTGTGAACGGCTCGGATGACGCGCACATGAGCAATGTCCAAAGGAGTCTAGTATATTTACGAGAGGATGTGAGGTAAAGCCTTGACATGTACCAAAGAATTATAGTACAATGATAAGTAATGACGACGGAACAAGAAAGAGGAGGTGTGCTCTATGGGAGAAATGACACGCTGGCAACACGAGTGCTTGTTTGCAGCGGGCGGATTGCTGGATCGGTTGCGCCCCTTAGGGGTGACTGAGGAACGGGAGATTGAGCGTCTCTGTCAAGAGGAAATCGCGGCCTGGCGTGCGCGTCCGACGATGGTCGTCGAAAGTTCCCTCCAGGAGCCGCTGCGGCATGCCCGCAATGCCATTCGGGAGCATCTTCCTCTCACTGGTGCTAATCGGTGGAAGAATCCGAAGACGAAGAAGTACGAGCACATTGCGCTCAAGTATCTCAACTTTTCATTGGAGGAGTGGCAGCGCATCAATACCGATAGCGAGGAGCGCTTTGCCCAAAGAATACGCTCGCAGCAACGCATTGACGATCCCGATGCGGTTGTGTGTCTCTCCGAAGACCTCTTGCGCAGGCCTGAGTGGTATAACTTGGCACTCGGGGTGACCATCAACACCGGGCGTCGGAGCACCGAAGTGCTCAAAACGGGGGTCTTCTCTCCCAAGACCGCCTATACACTCTGGTTTAAGGGCAATTAAAGACGAAGGATATGATTTAGAGGCGTATGAGATCCCCACGCTGGTGCCCGCGGATCTGGTGCTTGCGGCTATTGCTCGCTTGCGGCAGCTCCTGGATTGCTCTCAGATGAGCAATGATGCGGTCAGTCAGCGCTTTGGCCCGGTGATGCGTCAAATGGCGGATCAGCACTTACGTGACCTGATCCCCAAGAAAGATGAGGGGCAAAACCTGTATACGCATCTGTCCCGTTCCATTTATGGGCGCTTGTGTGTGCTCTATCACTGCCCCCCTGCCGTGTTCGATTTACAGTATATGGCGCATATTCTCGGCCACTATTGGTATTTTCGTGAGCAGGACGAGAAGAAACGGGCGAATCTGGATAGCACCTTGCATTATATGGACTATGTGATTGGTGATGGCCATGGCAACTTGGACGGTCGTCGTGGCATTTGGCTGGGTACGAAACCGGGCGTTGAGGTGCTTGATGCCTTTCGAAAGGAGTGGGAGGAGATGACACAGCCACCCGTGATACGAACAGGTCATTCTGGAAAGAAGAAAGAGCCAATGGGAGAGCAGCATCCGGTGAGACCCAAGAAGCGTTCCATCCTCAATTGTTTGCCCCAACAGAAGACCCTGTTTGATGCCGAGATGGAGCGGCGAAGCCTGGCCCATCAGCATGAATTGGTTGGCGCGCTCTTGAATGAAGCGGCCTGGTATCGGCAGATGGATGCGGAACTTTCCCCTCTTTCCGAAGCGCTGCAAGCGTCTACCCCATTGGGGACTCTGAGATCCTCATTGCAGTGTATCAGGGGGAGAAGCAAGACGTGGCAGTCAGCACCCATCTCCAGCAACGCTGGGGGGTGTCGCTTGACCAGATCGATGCGCTCTTTGAGAAGGCCGTCGAGGATGGCTATAAGGAGCCTCTCAAATACTTTGAGGGCACCCTAGAAAAACGGGAGAGCTATAAAGCAGGGGCGCAGAAGCGGGCCCAAAAATACCAGCAAACGGATTTTACCCTGCTTCCCTATTCCCAACTGGAACATATTCGGATGCCTGAAGCGGCGCAGGAGCGGGTTCGTCGCATTGTCCTGACCATCATGCGGCACAATGAACGGGCCCAACCCGTGATCGTTGGTATATCAATGCTGGACTCATCTACCAACTCAAAACGATCCGCATGAGCTGATCAATGCCTATCTCAAGGAACATGAAGAAGAGATCAAAACCATCATCGCCAGTTGGGTATTGAACCCCGGTATAATCGCAAAATGGAATCGATTCGGGAAATGTCACCATTCCTGAGGAACCTCTCCCTTAAATGGGTCTCTCCATGCTCTTCCTAAAGAAGTAACATCTCTTGCCTTTTGGTTGTGCTGTCGTCATACAAAAATTGTACAATAGAATTGTTGGTATGTAAATTATTTGGTATAGTTATGATTATACAAAAGAATATCAGGTACAATATGTTACGGAGGTATTACCTGTACCTGATATTCTTTTGTATAATCATTTAAGGGATGGGAAACCTCAACTTGTTGTACTTTAGAAATTGATGTACAGATTTATGGAGAGAGAACAACTATTTGCCCCGATTTCTCGTACCATAGATAACATAGTACGCAAAATATCTATACAACACAACCTAATGTAAAGAAAACGAACTCCATACTTGTAATGATGACCGGTCTATTTTCTTCGTCACGTGTATCTATTGTGTACACAATAGATACACGTGACGAGAAAATAGACCGGTCATCATTACAAGTATTGGAGTTCGTTTTCTTTACATTAGGTTGTGTTGTATAGATATTTGCGTACTATGTTATCTATGGTACGAGAAATCGGGGCAAATAGGTTGTTCTCTCTCCATAAATCTGTACATCAATTTCTAAGTACAACAAGTTGAGGTTTCCCATCCTTAAATGATTATACAAAAGAATATCAGGTACAGGTATACTCCGTAACATATTGTACCTGATATTCTTTTGTATAATCATAATCTATACCAAATAATTTTACATACCAACAATTCTATTGTACAATTTTGTATGACGACAGCACAACCAAAAGGCAAGAGATGTTACTTCTTTAGGAAGAGCATGGAGAGACCCATTTAAGGGAGAGGTTCCTCAGGAATGGTGATCATTTCCGAATCGATTCCATTTTGCGATTATACCGGGGTTCAATACCCAACTGGCGATGATGGTTTTTGATCTCTTCTTCATGTTCCTTGAGATAGGCATTGATCAGCTCATGGCGGATCGTTTTGAGTTGGTAGATGAGTCCAGCATTGATATACCAACGATCACGGGGTTGGGCCCGTTCATTGTGCGCATGATGGTCAGGACAATGCGACGAACCCGCTCCTGCGCCGCTTCAGGCATCCGAATATGTTCCAGTTGGGAATAGGGAAGCAGGGTAAAATCCGTTTGCTGGTATTTTTGGGCCCGCTTCTGCGCCCCTGCTTTATAGCTCTCCCGTTTTTCTAGGGTGCCCTCAAAGTATTTGAGAGGCTCCTTATAGCCATCCTCGACGGCCTTCTCAAAGAGCGCATCGATCTGGTCAAGCGACACCCCCAGCGTTGCTGGAGATGGGTGCTGACTGCCACGTCTTGCTTCTCCCCCTGATACACTGCAATGAGGGATCTCAGAGTCCCCAATGGGGTAGACGCTTGCAGCGCTTCGGAAAGAGGGGAAAGTTCCGCATCCATCTGCCGATACCAGGCCGCTTCATTCAAGAGCGCGCCAACCAATTCATGCTGATGGGCCAGGCTTCGCCGCTCCATCTCGGCATCAAACAGGGTCTTCTGTTGGGGCAAACAATTGAGGATGGAACGCTTCTTGGGTCTCACCGGATGCTGCTCTCCCATTGGCTCTTTCTTCTTTCCAGAATGACCTGTTCGTATCACGGGTGGCTGTGTCATCTCCTCCCACTCCTTTCGAAAGGCATCAAGCACCTCAACGCCCGGTTTCGTACCCAGCCAAATGCCACGACGACCGTCCAAGTTGCCATGGCCATCACCAATCACATAGTCCATATAATGCAAGGTGCTATCCAGATTCGCCCGTTTCTTCTCGTCCTGCTCACGAAAATACCAATAGTGGCCGAGAATATGCGCCATATACTGTAAATCGAACACGGCAGGGGGGCAGTGATAGAGCACACACAAGCGCCCATAAATGGAACGGGACAGATGCGTATACAGGTTTTGCCCCTCATCTTTCTTGGGGATCAGGTCACGTAAGTGCTGATCCGCCATTTGACGCATCACCGGGCCAAAGCGCTGACTGACCGCATCATTGCTCATCTGAGAGCAATCCAGGAGCTGCCGCAAGCGAGCAATAGCCGCAAGCACCAGATCCGCGGGCACCAGCGTGGGGATCTCATACGCCTCTAAATCATATTCCTTCGTCTTTAATTGCCCTTAAACCAGAGTGTATAGGCGGTCTTGGGAGAGAAGACCCCCGTTTTGAGCACTTCGGTGCTCCGACGCCCGGTGTTGATGGTCACCCCGAGTGCCAAGTTATACCACTCAGGCCTGCGCAAGAGGTCTTCGGAGAGACACACAACCGCATCGGGATCGTCAATGCGTTGCTGCGAGCGTATTCTTTGGGCAAAGCGCTCCTCGCTATCGGTATTGATGCGCTGCCACTCCTCCAATGAAAAGTTGAGATACTTGAGCGCAATGTGCTCGTACTTCTTCGTCTTCGGATTCTTCCACCGATTAGCACCAGTGAGAGGAAGATGCTCCCGAATGGCATTGCGGGCATGCCGCAGCGGCTCCTGGAGGGAACTTTCGACGACCATCGTCGGACGCGCACGCCAGGCCGCGATTTCCTCTTGACAGAGACGCTCAATCTCCCGTTCCTCAGTCACCCCTAAGGGGCGCAACCGATCCAGCAATCCGCCCGCTGCAAACAAGCACTCGTGTTGCCAGCGTGTCATTTCTCCCATAGAGCACACCTCCTCTTTCTTGTTCCGTCGTCATTACTTATCATTGTACTATAATTCTTTGGTACATGTCAAGGCTTTACCTCACATCCTCTCGTAAATATACTAGACTCCTTTGGACATTGCTCATGTGCGCGTCATCCGAGCCGTTCACAGGGAGAGCGGGCACGAAAACCACGCATGGATCGGTGGGTGAGTTCCAGATCCCCAATTTTCTCTCTCCCAAAAGACTATAAGAAGTGCGCAACGCAAAAGCGATACCAGGAAAATGACTGGAACCTTCTGTAGAACAGAGTGAAAGGAGAAATGCTCATGCAAGTTTATTGGATAAAATCACCCTCGGAAATCACCCCGGCGGTGGTGAAACGTCAAGGGCGCACATACACATGGATCGCCGTGTTCAATCACGAGAAAGATCAGGTTGAATATTTACACATCGAGAAACAATCCCTCCAACCACGCCATGTACAAGATGAAATCGATGAAAGAGAAGCGACAGAAGTCCAGCAACGCACTACTCGCAAGCGCATCCTGGGCCATCATTAACGCATCTCTGAACAATGCTCAGACAGAGAAAAACACATGCTTTCTTTCTCTGTCTTGAAAAGGCAAACCAGAAGAGAGCCTCCTCCTGCTCTCGGTTTAGACACCTCTTCCAAACACTAACTGCTCTCGCGCTGCTTCTACCACTTCTCGGTTCACCTGTTCGACCTCTGGATTAATCTCGATGATCCGTTTCATTTGCAAGAGCAACCGTTCCATCTGCCGAAAATTCCCGCCCGTCATACGAATAATCTGCGCCACTGCCTCCTTCTCGATCTTCCTCCCCTCACCTCTTCCTCCGCCAAAAGAGCGCACCTGTTGTTCAACAAGCTCCTGCTGTTCTTCTTTTCCCAACGTCCGATATTGATGGACAAAACCCACCCGCGAATACAGTTGCGGATAGCGGGCCAAACGTTTCTCCAGCCCAGGCATCCCGATCAACACTAGCCCCGTGGGACTTCGATCATACACATCTCGCAGCACCTCCACGGCTTGTGGTTTGAGTCGATCTGCCTCATCCACCACTAACAGGTCTACCTGCCCCGGACGCACCATCCCTTCCACCGTCTCCACCTCTTGGGGCACGGCGCGGGCCGCCTCTCCAATCACCCGCAGACTCCAGCGCAGCAGCGCAATGTCTTTCTCTATTTGCCTGGCCGTCACCGTCGCCGTGGGCGTATAGAGCGCGACTGTCGGCCTGGGATTCTCTGGCGACAACCGGGGCTGCACCACCCCATGCCAGGACAACAATGGCTCAATTTCATCCCAGCGTGCATATTCCTTCGCCGACTCGGTTTTTCCTACTCCTGCTGCTCCATAGCACACCCCGATATAGCGCGAGGCTCGGCACTCCTCACAGAACTCTACAAATCTCCCATACTCTTTCGTCTGCACAAACCGCTTCCACAGCCGACGATGCACCTCTTCTTCCTCTTGCTCCTCACCCAGCCCTTCCCAGACCACCACTCCTTCTCTCGCAACCGGCCCCATGAGCTCCTTCGTCTTCGCCTTACTCATTCCTATACCTCTTCAGACGCGTTTTCGTTGACACAGGGGCCTCTTGCTCCTGCATCTTGGCTGGCGAACTTCCAGCTTCACTGCTGCCGCTTTCTCCCCCACTGCTTGCTCTGCCGTAGCCCTGCGGCTGGTTTCGGCTTCGCGTTTCACATAGTGCTTCACTAACGCTTTTCGCTCTGCTAGTTCTCCTCTCAGATCCCTTCTCCTTGCCTGCCGGGCTGCCACAATTTCCTTCAAACTCACTGTTTGTCCCGACAATTCTGGACAGATCGCCCGGCAGACAAACCGATTTTGAAAAAACACTCTGATCTCTGCGAGATCTATCGGATCATACCGGATCATGACCTCCTCCCCCACATAGGCCGAGAGGGTGGGATCCAGATACGTATATCCTTCAAAAGCAATCCCGCTCTGTTGCACCCGCCGCTTCCTTGCCACCTGCACCAACAACAGATCTAACTGTTCCAACGACTCCGGCATCCTCGGCAACAATCCCCCTTCTTCCCAGCGCTCCTGCGGTCCCCTGCTGTGCCCTTTTTGCACCCGACGGTGATAGTCCGAGAGCAACCACTCCCGAAAGCACTGCTCCAACTCCCAGAGCGTCAGCACCCCTGCTCTCTCCTTCCCGGCTCCCTGCCCCACAGACTTCGGCCACGCTTCCGATGGCGCATAGCCGGGCTGTCTTTCTAAAAAGAGTTGTTCCACACTCTGAAAAAATCGCTCAATCTTGCCTCGCCCTCGCGGCCTTCCCACCTGCGAAAACACCAACTGCATCTTGAGATCCGCTCCCACCTGCTCCAAATGCACGCTCGTAAAATCACTCCCATGATCGGTATAGAACACCTCGGGGATACCACACACCTGCCACTGTGGATCTTCTTTGCGCCAGATCGCCTGCCGGAGTGTTAGTGCCGTTTGGATCGCACTGGGGGCTGACCACGAGAACCGATAGCCAGCTATGGCTCGGCTCTTATCATCCTCGATCACCGTCAACCACGGTCGAGCGCTCTTGCCCTGCCCATCTTTGACCCAAATTGGTAACAGACAATGATCCGCTTGCCAGATCTCGTTGGCCCTTCCCGCTTCTCGCCGATACAACAGCTCATATTCCTCTCGATAGCTCCCGGCCCCCTCCTGCGCCAACGTCACCAACGCTGGTGACAACGCTTTCACGATTCGATACACCTGCGCATAGCTGGGTTCTTCCCATCCCTGCGTGAGCGCAATCGCACTCACCTGCCGATGGATCGTTGCCATCGATCTGCGCGGTTTGCGTAAGGCCAATCCCTCGATCACTTTCACCACCTCTTCCGAGAGATTGCGCCGCGTCCCTCGATCCGCACGCGGTTGCCGGGCCAATCCACACAGCCCATCTTCCCGATACTGATGCACCCAGCGCTGCAATGTCGAGAGCGGCACTCCATATTCCCGCGCCACCTCCGTTTGCGGCACTCCTTCTTCCACACACTCTTTCACCACTTCATAGCGCCTATATGCCTCTGTCCGTTGCTCTTCCGTCAACTCCGTGAGGCTCGGCACTCTTCTCTCTTGCTTCATACTCCCTCCCTGTTGTTTCCTCCTCCCTCTCACCCCATGAGCCAGTATATTCCTCTCCCTTTTCCATCAATTTTCCATAAAAAGTGAGGTCTCCAGCTTCTCTTAGAGATGCCGAGACCTCTCCTTTTCCTGCTCTTGTCTCCCTCTCTCACCAGATAGACCTATCTTATTTACATCTTTCCCCATATATCACCTCTTTTACCCAGCCACTTCATGTTCTCCTCCAGATTTCCCCTCATCTATTTCGCAAAAAAATGGGGCTATCCTTTTCTTTCTTTTCTTTGAGGCTCTTTTTTGCACAGTCTTTGATAGATCCCTATCGGCACGCTCCACACGCGCTTTCCCCATACCCTCTATGTCTCTCTCTCCCTCTCCTCCTCCGTTTTCACCACCTGTGACGACTCCTTTTCACCATTCCTCTCCGCTGCTTTTTGCCCCTATTTCACACCTTCCCTGATGCTTCTTTGAACAGCTTCTTTGAGGGCTTTCCCCTGGCTCCTTCCATCTTCTCCTCCATTTCTCACTCTCTGCTTCTTCCCTTCTTTTTTACCACTCACTTATCCCGCCAATTTTACCCTCATCTATTTTGTCGATTTACAGAGGCCCGAGGGAATCGTGAGTCAATTTGAACGGATTGTGGGGAATGGCCAGGGACACCCCCATCTTGCATTAACACGACTGTACCAGCAACTCTGCCAGGAACTTTCTGATGGAACTGCCCATACCTATCTCCAAGCATTGCTTCCTTGCTTTTCGTTCTTGGAGACCTGATCCCTGGCGTAAGCAGCGTCAGGATTGTTGGGATAGTCCACCAGAAAGCATTCGGGAATCGGTACGGGATTACCTGCTTCAGCAATTACACTGCAAAGTGCGCCGCTATGGCATGTATGAAATGGTAAGACTTTCTGTACAGAGCCCAAGCACTGTGCGCACGACCTCTAGTTCCCGCTTGAGTTGACGGATCTCCTCCTGTTCAGGCAATTGGTGTCCGCTGCCAGGAAAAGCTTGCTCACCATGTGCACCCTATTCCTGACACCAGCGGCTCAAACTGCTGTCAGAGATGCACAGGTCCTGTGCGATCTGGCTCTTTGATTTGCCACTGGTCTCGGCCAACTTGACTGCTCCTACTTCCAATTCTTTTGTTACGTTGAATGCCCGTTTTGCATAGATACTGTCCTCCCTTTGGAGCCTCTCTTCCCAACTTACACCTTCCACTAAAACAGCACAATTACAGTCTGGAAGTTCGCGGAAAAAGGAATAAGCGTTTCCACCTGGGACTATGCCGTCAACTATCGTATAACACGGTCATGATGATTTGGTGGTTGAGATCTGGTCAGAAGCCCTCAATCGCCTGTTTGTATCACTCCCAACGTGTAACGAAGCAGATCTGTCTCCGTATCTTGTGGCTCTCTGCGGAGCAAAATACCACGCCCATAGGAGCGAGAAATTCTGCCGTCAGGATGAATGGCACAACACCAAGTTGACCCGTGAGATGTTCCCTTTCAGCAAGGGGCTTCCAGAAAGCTTCTGGGCACACTTTCGGGAGAGGTTGCTTGCTTCCATGAGGCTAGCTTGTAAGAGAGCGGGACTGGCTCGCCAAAAAGTGCCCACATTTCACGTCATTTACCATCAAGGGAAAGGACAGGGGGAAAGAGCGACCTCCTGCGTCAGCACGTTCTTCACCGATTCATCATAATCATCAAAAGTGCGTCAAGCCTCTGAAACGATCAAGATCCAGATGGGCGAGTCGAATGATCAGGTTGTGCGGTAAAATCATCTATTGTGCTTGCAAAGGCTGCACGAATCAAGCAGATTTGTCGCTGTAAGTCCTCTTCGTTAAGTTGGGTAAGCAGTTTTCTGGCTTGAGAGATACTTGACTCAGGAAAAAATCTGGGGATGCTTTTTCCCTCGCTTGAAAAAAGATCCCGGCTTGATGGTGTGGTGGTAAACAAAGGAATATCTCCACGAAGTAGGTCAGCCCGTTCAGCAGGAATGAGCCTCTGCAGAGAGGGCTGAAACTCAACCGCCATCCATAAGCGATCAAAGAGGCGCTCCTGCCTCAAAGCGTCCCGCAAGTTATTCGGATGAAAACTTTCTGTGAGGAGATGACCATAGCTGCTCGTGGGACGAGCTACGAAGCGGATCTCATCATGGGCAAAACGCGGAAGGATCTTTGCCAGGAAAATTTCCCGATGCTCGATGAGTAAGCGATAGATAGCAACAAAACCTCTCTCGATGCATTCAATATACTCGGATGCCTGCACATACTTGCCAGCCAGTTTCGGGCAATTCTTACCTCCCTGCAGCTTTACCTGCTCACGTATCACCTTCATTTCGTCTGTCCCCAGCCCTTCCCATCGCGGCACTGGTCGTGGGCTGAGTTGCCCCTCAGGATTGCCAAGCCCGCTTATGTCGACTCCTTTGGACGCATCATTGGACCAGAAACGCTGTGGCAGTAAGGCAATGCGCATAACAGAATGATCGAGCGCTTGCTGTGCAGGACGTTGCAGAGCAGTGATGCTTTCTTTGCTCACACGAGGATGAAAGAGCGCTTCCAGGTCTATCAAGAAGGGATGTTCGCCAGAGGCAATGATATTCTCATAATGAAAGTCAGAGGCTTCCAGAACATAGAGAAGAGCCAGATAACCTCCTTGCCGTTCATAAAAGCTGATGACTTCTTCCTCAGAAGAGCATGCGGCAGCTGAGACGCATTCAGCCCACCCATGTGTTCCATAGTTGATGAGCTTCAAGGGACGAAAGGATGGATGATTACCATAGGTGTTTAACCAGCTCAGTACCTCTTGAAAATGAATATCAATACTCAGAGATCTGGGCTTGTAGACAAGTTGCCAGCCTGAGCGAAATGTCAGGATCATCACGCTCCGGCCATGGCGATGGAGATCACCAACTTCGGCCTGCACTTCGGTAAGCTGACCAGGATTCTGCTCCAGAAAGAATGTCGTCAGGATCTCCTCCCAGTCCTGACAAAGGTGGCGTAAGAATTCGATGCGGCCTTCGACCCAAAGATCGAGCGTGATCATCAGCTGACGGGCCAGGACACAGTACTCTTCCAGGAAATTCAGGAGATGCTCTGGCTGGCTCAAACGCTCTATGTAAGATTGGAAACGTTCTTCCGGCGTTTCTCCCAGCAAGAGTCCTCGCAAACGGGCAATATGCATTTCAAGCACCACGGCTCTATTTAGCCTGGCAATCCATTGACGAAACAGATGCGGTAGGAAGAGTGAGAGGAGTGATTCAGGCTCAAATGGGAGATGATGATACTGCTCAAAAAGCTCACGTATCAGCTTTTGTAAGCGTTTCACTCCTCCTTGGAGCAATGGATAGAAGGGATATAAGATCCGGTAAGCACCGCGCTCTGGCTCTACATCTGTGAAGAAACGCCTCATGGTCGTGGGCGAGACCTCTGTTGCAAGGGCCTGCTTAAGCGCGACTAGCCAATCAGGAGGTTCTCTTTGCGACAGGCGCGTGTACAATGCCTCGCCTGGCTCAGCCAGTAGGGCACACAACTCTTGTTCGCTGAGAGCATCCATTGCCAGACGATCGGAGAAAAGTCTTCCCTTCTTAAAAGGCTTTTGCTCCTTCCAACGCTTGAGCTTTTTTAGCGCCTGCTCGGTGATTTCCTGGCTCTTGAGAAAATGCAGCCTTTCTTCCAGAGGAAGGGAGGCGATGCGTTCAGTAAGCGTTGTAGCCTGATACCAACGCACCCCCTCTATACCTGATGACGTATCTTCAAGCGGGAATATGGGGTCAGTCTCCATGTATTTCTTCCCTTCTTTTTTCATTGCTTGTCATCAAAGGATGCACTCATTTTGACGTTATTCCCACAGCAGCACTGACGGCAATAGCTCTGGATAGAGCATACGCAGCAAGGTATAGCCAATACCGGATGTGCCATGAAAAAAATGAGGTAGCGAAGCCCACGCTGGCAGAAAAGTAGGCAAGGCAAACGCTCCTCTTTGTTCAGCCTTGATGATCATTCTCACGATATGCTGTTGCGCTATCTCTGCGAGGTCTGATCGCTTCAAATGCAGAGCGGCTGTCCAGAGCAGCTCTGTACGTCCGCTGTTCCCGCAACAAAGGTGATCAAATGCCTGTACTCCAAAGCGCTTTGTTGTTTGCAAAGCTGCCTCAATATCCCGCTGAATCTGCGGACTGGCCAGTAGGGGTAAGCCGCCGATACGCGCAAGTCCAATGCCAGGTGCGCCATGACACCACGTCATCCACGACTTGGATGCTCTCTCTCCCAGTTCCTCTGCCCAATTCTCTACTTCGGGCCGAAATGCGCCATCTTCGTAGATCAAGCCCTCGCGGGCCGCATCCAACAAATCAGCATCTCTCGCCACAGCGTAAAGCCGAAGTAAAGCATACACAATACCAGCCACCCCATGGGAGAAACCAGTATGATGTGTTCCTCCGTACGTTGGCCATACCTGGCATCTTGCTGCGCTCATCGTTCTGGTCTGCAGCAAGTGTTTGCCGCAAAGAATGGCACGGTCCAGAACCCATTGATCCCCCGTCCTTTCATGAAGAGCCAGCAACCCAAGAAGAGCGCCAGCTGTTCCTGATACGATATCCAGCCTCCGGTCGGCGGCAATCTCTTCAGCAGTGATCAATCTGGCCACATCTTGAGCCGAAGCCAGAAACCGCGCATCATCAAGTAACTGACTGATACGCGTGAAGGTATACACTAGAGAACCGATACCAACCGCACCACCTATCCCCATCTCCTGGGCTAGCAATTGACCATTTCCATGCAACATCTGTTGTATCGGCTGGAGAGCCGCACCCACAAGTTTTAGATAACTGGCATCCTCTGAGATTTTGGCTATAGCAGCCAGGAAGAGTGCAATACCAGCTGTTCCCTGAAACAAGCTAAAGCCCATTGATCGAAGCTGATGACACCGCGCACACTTTAAAAACTGTGCTCCTACCCATGTTACCCCTCCATCTCCCAGAGGTATGGCTTGCATAGCGATATCATTAGCGATTTTCCAGGCGTGAGGGAGCAAGATATCAGAAAAATCCAGATTCAGCTCTCCAGCAGAAGCCGGACCATCTTCAGTCGCTTTCCTGGGCACGGAACTGACAACTCCTGAAGTGATATCCCGCCTGAGCGCACGTTGGAGCAGGTGTAGTTGGAACTGCATATCTGCTTCGCACCAGGAATTTAAGCGAGCTTGTAGCAGGTCGAAAGCTGATTGGTGCAGTCTGAAGGGACCTGCTTGCATATGGGCCACGAGCGGCAGGTTTTTCTCTACGGGCAGGCGAAAAACCGGGATGTCTCCCTGGAGGAGAGCCCTCTTCTCGGCTTCGATTATAGCTTGCCATAGACTATCCTTTGCTGCGCCTCCCATATTCTCCAGGGACTTCAACAAGAAATGACGCCTGTTCTGGTCACTGAGGGCTTGCGGGGTCAATAGCTTTGGCAGAAGATCTCTATATTCCCGAGGAGCACGAGAAATAACGCGCACAGATTGCTCATGTAGGGCAAGCAGAGAACTACCCTCAGCTAACAGCGCGGTCCGATAATGAAATATCAGTTGATACATACGTCGAAATCCGTTGCTCACTTCATTGCTCTGCTCCTCTAGCTGCAGCGGGCAGCCACGATACATAGCAGTATTATAACGGGGGCGCGGTTTGAGAGATCCATACGCGAGAATCATATCCTGGCGGAACGGAAGTGTAAGGGCGTCTTCCTGGGCATAAATCTTTTTCCTGGCGGCCATAGCAAAGCCACTAATATCGCTGTACTGACCCCCAGCAGAAGGTTTCTCAGCCTGCTGCCAGGTTGGCAGTAGCCCGGTGTGTAGTACAGAATAGCTCGCCTGCTCCCAATCGAAACTCTGAGCCTGCAAAGCTGATTCCTGGCTATCAAAACAAGGAGATGTGTGTAGAAGTACTTCTGGATCGACGAGTACAGGGTACTCTCCATGAGCAACAAGATGCTCATGGAAACAATTCGTTCCACCAAGGAGATAGACGATACAGAGTAGCATGCCAACGCGTTGGCAGTAACGCTGTGTTGCCGCAAAGTCCTGGCAGGGCTCCTGCTGTACAAACTCGACCCATCCATACTCGACACGCTTGAGAATGGGAAGGATCTTCATAGGAGGCGTGAGCCCTTGCATATTACACCAGTTCAGCAGATCATAATAGCCTGCTTCTAACCCTATATTTTTGGGTTTGTAGACTAACTTGAGGCCGGAGGCAAACTGTAGCGCCATCACGCACCGCCGTCCAGTATGTGGATCAGAAAGCGTTGGCTGAATCGTTATCACGTTCCCTATTTCAGTGTCTTTGCCGAATATTTGCTGAATATCCTGCCAATCAGCGGCCAGGCGCTGAAGAAACTCGATATGAGCGTTTACCCAGAGGTCGACAGTAGTGGCAAGCAACTGGGCCAGAACATAGTACTTGCGGAGAAAGGTAATCAGCCCGCCCGCATACATCTGCTCGATGAAGCGCTGATACACCATCTCTTCATTGGCAGATGCTTTGCCGATTGTATCCAGGCGTCCAGCCGAGCGCCAATAGCCCTGAGCATATGCCTGGAATGCTGTGTGTAGCGCCTGTATCGATAGAGAGGTGAGAATCTGTAATAAAGAGCGTTGCAAGCTCAGATGTGCCTTCTCTGTTAGCAAGTAAGCCGCTGCTCCAGCCTGATCCATATAGCGTTGCTGTGCTACCCCGATAAATGGTGCTAGAATTTCTTCAAAAGGGGAAGGATTCGAGAGATCAAGAAAGCTCCACTGCCTCTTCTCCAACATAACTGACTCGCCGGCCATCATCTCTACAAGACGCAATACATCCTGTAAAGTGTTAGTCCAGTTTGGCAGCGACGCCCGCTTGCCAGACAGTTCTTGATCCGCAGCGCTTGTGCCGGAAGCAATGCCCATCATTGCATACAGGTCAGACAGTGAAAGAGGCATAGTGAGTAAATCCTTCCTTACTCGTCAAGATAGAAATTTTCGCAACGCATCTCCGGGGTACTGGCCCCTAAAATCCTTTTAGAGGCCAGCGCACTATATTTGGACCAGGAGAGCATAAGCCCATCTTTTAACAAGCATCTCAAGCCTGTGTCTGTCCAGGATGGCTTACCGGTGATATGGTGATAAACCACTGATCACACATAGTACAGACACCCCCGATGCCAACGACCTCTTCAAGTTCCTGCTCGGTGAGCTCTTCACCAACAGGAATGACGGGTATGGAAGAACTCCATTCGTCCCCACTTTCTTCTTCGGCTTTCCAGGCCTGGATAATGCTCTCGATATTCATTATGGGTCTCCTAGCATATGATGCTGCTTTCAAGTCCTCTTTACCAGGAAGAGCCGGAACCAACTCTGTGTTGATACCTCTGCTGGGGAAGAGACTACGTTCTCAATATAATTTGGCGCGGGAGAAAGAAGGGCGATCTTTCTTCACTTGTTGCATTGTTCGGCTAACCTCTAGCTGGACGCTGCTAGAGGTTAGCGTAGCACATGAGCTCTAAGCCGTTCTAGCGTTTCGTAGAAAACGCCTCAGCTCGCATACTACCAGTCGCCACCCGCCCTACAGACTGTAACGGATTCTTCACCACATTGGCCTCCAACGACCTCTTCGAGCTCCTGCTCAGTAAGCTCTTCACCAATGGGGAGAGCTGGCATGAGCGAAACCCATTCATTGCTTTGTTCTTCTTCGGCTTTCCAGGCCTGGATGATGCTCTCGATATTCATCATGGATTCCCTTTCTTTTTACAAAATCTTTTCAGGATAGCTTCCAGCATTTTGCTAGAGCCATCGCACACCACTTCAATACCTTCCAGGTACTTTATAAAGAAGCGAGCACCTGCGCTCTGCTCCTACCACTCCTGTCCATCAGCACATTGTCGGCCGGTGAAAGCATGCTGCCCACAAAATCCCCCGACGACCTCTTCAAGCTCTTGCTCAGTGAGCTCTTCGCCAACAGGGAGAGCTGGCATGAGCGAAGTCCAGCCATCTCTCGCCTCTTCTTCGGCTTTCCAGGCCTGGATAATGCTCTCAATATTCATCATAGGGTTCCTTTCTTCTTGTACAGCATTCCATTTACAACCTACAAAGAACAACGATGAATCATCTATGGCAACGGCCAAACACTCGTTCCGATGATAGCCTTCATCAGGACGAACCAAGCTTTCCAGAAAATTCCTGAATGCACTGGTTTCTGGCAAACAAGGTGCTGTACTGGCCGATATGCCTCATTTCAAGATAACCTCGCCTATCTCACTTACCGTCCTCGTCGTTGTGAGTCAACTGGCTCTGGATCAACTGGGCATAATACCCATTGCACTTGAGCAATTCCTGATGTGTTCCGCGCTCAACGATTGAACCCTGATCAAGCACCAGGATAAGATCAGCGTCACGAATGGTGCTCAAACGATGAGCGATAATGATCCTTGTACAGGCCAGCACACTGAGGTTGTGCTCCACAGCCTTCTCGGTTACCACATCCAGAGAACTAGTTGCCTCGTCCAGCAGAAGTAGAACAGGATCATTGAGCAATGCCCTGGCTAATGCGAGGCGCTGGCGTTGTCCACCGGAGAGTGCGTTTCCACTTTCTGCAATATGGGTCTCGTACTTCATCGGCATCTTCATTACATCGTCATGCAAGGCAGCCATTTGCGCTGCTCGTACGACGTCATCTATACTGGCGCTAGGATTACTTAAGGCAACATTTTCGCGGATTGACCCACTAAATAAGCTGGTATTTTGCGTGACCACTCCAAAACGCGAGCGTACCGCCTGGAAATCCAACTTCTTCAAAGGAATATCGTCGTAAAAGACCTCCCCACTGCCTGCTTGATGCAGGCCCAGAAGTAGATTGCCCAGGGTGCTTTTGCCCGAGCCGGTACGGCCCACAATCGCAACTTTTTGTCCGGCATGAATGCTAACAGAGATATCTTGCAAAACTGGAACGGCATCGGGCGCATATTGGAAAGATATCCCTTCGAGACGTATGCTCCCGGTCAACTGTAATGGCAATTGCGCAGCCTTGCCACCCTGCTCTGGTTGTGCCTCCAGGACATCAGCAATGCGCTCCAGATGGGAGTGAATTAATTGAAAACTCTTGCTATTGTTGACCAACGTGGCAATAGGCGTGAGAAAAGTAATCGCCAGTGCGTTCAATCCCAGCATCGCCCCAACGGGAAGCGTACCGCTAATCACCTGCCATGTACCAAACCAGAGCAAGGCAAGAGGTGCACCTACTCGCAATGTGACCAGCACAGTATTCGTCAGGGCGGAAACCAGGTTGCGCCGTGCTGAGATATTGAGCTGCTCGAAGTACAAGTTAGAGCAGCGTTCGAGTGCCTGGTCCTCAATCCCCATAGCCTTGAGCGTCATCATGCCAGCAAGTACTTCCGTCATATATCCCTGGGTTTTACCCTGGGCAGTCAACTCTCGATATGAGAGCTCACGGACGAGACGATTGGTACCCAGCAGAATAGCTACTTGCAGTAAGCCGAGACCCAATACTAGCAAGCTAAAGAGCGGTGACAGCGTGAAAAGAATGATGAAATCGATAATCACAAAACTGCCATCCAGTACCGTCGAGATCAACTGGTTACTTAGGAGATCGCGTATCACAAGGTTACTATTCATACGCGCCAGCAGATCACCGCTCGCGCGCTGCAGGAAAAAGAGCAGAGGCAACCTGAGCAGGTGCTCAAAGAAGCGCAACATCGTACGCATATCGGTATGCATCTGCATATAGAGCATGAGCAGTTCACGCAGAAGAGAGACCACGAGCTGGGCAAGAAGTACGATTACTATGCCAAGGCCCAGCAAAGTCAGGACATCGTGTAACCCCGAAAGGACAACATGGTCAATAACCACCTCTGTTAGAGCTGGAGTCGCCAGGGCCAGTAACTGTAAAAGTAAGGAGGCACCTATGATTTGCAGGAATGCTACAGGTACTTGCTTTACATAATTTGCAGCGTACTTACGCAAATTCACCTGCTCCCTTACGTTGCTGGGATCAAATAGGGCTCCTGGCTCAAGCAGAATGACCACACCGGTAAAACTGCGGCAAAATTCCTCTATAGCCATGCGCATCCGTCCTGTAGCGGGATCGACCAGATCAACGTATCCAGGCGACCAGCGTTCCAAAACCTGAAAGTGATTGAAATTCCAGTGGACAATGGCCGGTATAGGGACAAAGCGGAGATCGCTTGCATTCTTTAAGGTGATGGCGCGTGTTAGCAGGCCAAAGGAGCGAGCTGCTTTAACAACAGCAGAAGCAGAAAGACCGTCGCGTCCGACGCCACAGCGCTCTCGGACCTCAGAAACGCTGGTCTTGCGTCCATAGTAGGTCAAAATCATGGCCAGACAGGCTGCTCCGCACTCGGCTATGGTCAACTGATGTAAGACCGGTACACGCTTCCTCCATGGACTTCTCATAGACGACCGTTTCCGTCTAGCCATTTCTCGTAGAGCCTTTGGCTTTCTAGAGGCTGGGGGCACCTGCCGCTGCTCCAGTGTGAGAGCCTTATCTGAATCAAACTGAGGCATGGTATGCTTCTCCCGTCGATGCAACAGGCTTTGAGATAATCAAAGACAGGACAGATGCTGAGCCAATCTGAACTTGGGCAGAGACAAGGCTGTTGGCATAGAATTGAGCAGGTAATGGGATGGCAGATTTGACGAAGGCAGCTATGGATGGCCCTGAAATGATCTGTGAAAGCCGACCATCAAGCCTGTAGCGTTGCTGCGCCTCGGCTGGACTCAACACCTCTGGTACGATGATATCAACAGTCCCATTGATCTGCTGCTCAGATATTCCTATATGGAAGTGAACACGAGCGCCTGTATGCAATTGCAAGGGATGTATAGGAGTGATTGGGAAGAAAAGGAGCACTGTGCTCTCCTGCATGACCTGCTTGCTCTGTATGGAATGCTGTGCAAGCACTACCCCGGAGCCACTTGCATAGATTGGTATCTGACCAAGTGAAGCAATCACAACCATCAAGGCGAATAGGCACATCAGTATCCAGAGAAACAGAAACACGGGCGGTGCTACCAGACGTGGCAGCACATTCTGTTCTTTGCTTTGTCGATAATAGTCCAACGCTTCTTTACGAAACAATGAAGATGTAGATCGCTGCATGCTCAAACCTTTCCAAAGCCCCTCTGAATTCCTCTCGTATTCACTAACTTATCTGCCTGGAAGTGTACACGGAGTGCAGAAGAAAACACATCTCCCGTTCGAGGTATTTTTATGGGAACTGAATTCTGGATGAGAGAAGGTTTTCTCCCCCTAACGGTGGAGGGATGCAACAAGCCATTTGCCGTTTAAAAATACTTCGGTCGAGGGATGCGGGCTCAGCACTGTTGCGGATAAAGTTTGAGGAGAGCGATATTCAGTAAGAAGGCCACTCATTTGCACACAGCTTTCTCTGGCGCACCCAATCGTTTATGCGCGCAAGGTATCGTTTGTTCAGGCCCTTTGCCGAATGGGCATGTCTTGATATTACCTTAAAAGGAAATGTAACCAATGCAAGCTGCTCAAATACCCATGCATGTCAGCCCCTGGCCAACACTCTTAAAGTTTGACCATCAGGTTCCTATCCTGAACTGGACCTATCCCTTCACGCCCTATGAGCCACCAATGCCTGATCCCTTCTCGATTTATAAGCAGATTGCTTCAAAGCCTCGCAGACGGGCGCTCTATCTGCACGTGCCATTCTGCGACACCATCTGTAGTTTCTGTCCATTTACGCGCGGCCCCTTCCAGGGAACTGATGAGCTCGATCTCTATGTGCAAGCGCTGTTACGGGAGATTGAAATCAAACACAGGCACCCAACTATCCATTCAACCCCGGTCGATTGCATCTTCTTCGGCGGAGGAACTCCCTCGGTTCTGCGTGCCGAGCATTTTTATCAATTAGGTGAAGCATTACATCGCTCGTTTGACCTGAGCCGGCTCAAAGAATTTACGATTGAATGCGAGGTCAAGAGTGTGACCCTGGAAAAGCTCAAAGCCTTTGAGCAGATCGGGGTCAATCGCGTGAGTTTCGGCGTGCAGACCTTTAACTCGCTCTATCGTGAGCTCTTCACCATGACGGCAACCGTAGATCAGATTCGTCGGGTAGCTGATTGGGTCAACGAGCGCTTCCCCTTGACGGGCGTTGATCTGATTTATGGGATGGCTGGGCAAACGCTTGATGATTTCGTCACAGATATCGACCTGATCAAGGAATTAGGAACGAGAACCATCGATTTCTACCCCCTTAACAACTGTTCCTCCCAGCTGCGCTTGCATCAGGCTTTTGCTAAACATGGGCTGAAGCCACTTTCCGCGAATACAAAGCTCAGCTACCGTATGTTTCTCAATGAATACATGCGGGCCCAGGGGTATGTTCCTCATAATGGTCATTCCTTCACACGCAATATAGCGCCTGCTGACCATCCACGCGTTGTCGTACAGCGTAACGGAGCCACCTTCCTGTATCACGATCTGTTCAATGGGTACGCTGAGGACTTTATTGACGGCTATGGCGCAAGTGCGGCCAGTTTCTTTGGCTCTCAGCTCGTCTACAACGTCAAAAGCCGGAAGCAGTATATGGATCGGCTGCTGGGCGGAGAAGAGCGAGCATGGTTTCATGCTTATAACGGAGTGAAAGTTGCCGGAAAAGGGATTGTCGCTTTCCCTTATCGTGGAGTCTTAGAAAAGGCAAACATTGATTGGAACAATGTCGATCCCGAAACACGTGCGGCCTTCGAAGAATCGGTGGTTCAGGGGCTGGCTGCTGATCGTGGCACATCCTATGAAATTACTGAGACTGGCTGGCTCATGTATGTCAATTATATGTATGCACTGATGCCTCGCCAGGATCAGAGAAGGTATACGAAAGCAGTTATTCGTTATCTCTCTGATGGACGTCCAATTGAAGAGATGGCATTTTTCCCCACTCGGAGCAAACGCGCGTCCATTCCTATAAGAGTAGGAGCAACAGAACTGAGATAGAGCCACAAACGCCTTGGCTACTAGAGCAGGTTTTGCTCTAAGGCATAGCGGGTAATTGCACTGCGGGTTGAGACGCCTACTTTGCGATAGATGGAGCGGATATGGGACTGCACTGTCAACGGGCTAATGATTAACTTATGAGCAATCTGTGCCCTGGTGAGCCCCTGCGCCAGGTGGCGCAAGACCTCAACTTCCCGTCTGGTCAGATGATCAGGAAGGATAGGTTGCGGTGGTGTGCATCCGCTCTGAAAGGCCAGATTAGTAGTAGGGGCGAGATCCTCTAGCATAGCACAACCGGAGTGGTAGCCCTCCCGCCAGGCTTCGAGAAAGGTATCCGACCCGACACTTGCGCGCGCTTCAGCCTCTGCCGCAGCAAAGATAGCACGCTCACGAGCTGACAAGGGAAAATGGAACTGTTCGCGTAAGGCCTGGGCCTGGCCCCACAGGGATGCCGCTTTTCGACCCTGCTGCCGCACCGCATGACTTCTGGCCAGAACTTCTAAAGGCAAAGCAGCCCAGGCATAGCCCTTGCTCTTCAGATAATAGGAGAGGCTGGCTGAGCAGAGTGCTTCAACCTCAGTATAATTGTGCTCGCACAGTTCTGCCTCTGCCTGCCGAACGCTCAAGACGGCTATTTTTCGCTTATCCCCCATCCGGGTCATTGCTGCCAGGCATTCCGTAAACTGCTGGCGCGCCCTGAGCACATCACCCTGACTCAGGGCCAGTTCTCCCAAGAGGACGAGATAGTTAGTTGGATAGATGGTGTTGGCCAGGGTAACCGGAAGCGCCTGGCTCTCTTCAAGCAATTCCTGGATACGTGGGAGATCCTCTTGGGCTGCAAAGAGCGACTCGGCCAGGCAGAGCAGTACATTGGCCTGGCTAGAGACGTCTTCTAGCTTTCGAAAAAGCGCGAGACTCTCCTCTAGCTGGAAGACTGCCTGGGGATACTCTGCCTGTAACGAGGAGAGAAAGCCCAGAGAATATAAGCAGAGCGCGCGGCCGATCTGATTCTCCACTGAAGCATTGAGTTGTAAGGCCTGCTCACCCAATCGTGTGGCCTCGGGCAAATGGCCTCGATTCGCTTCTGCCCAGCTCCAGCAGTAGAGCACCGATGCGCTTAAGGCGGGACGATTTTCTTTCTGAGCTAGGAGTAGCCCCTCTTGGCAGAGAAGTACACACTGCTCGTAGTCATCCTGAAACAAGGCTAGAAAAGCGGCAGTAGTGAGCGCAATGATGTGGGTGGAGATGGAAACCGTTGCAGCTCTCTCTAGCGCACGCGCGAGAAATTGTCGTCCCTCGCTCAAATGTCCACTCATATACCAGAAACCGGAGAGCGATGTACACAAACGTAAGGCCATCTCAGAAGTGTGTAGGATTTGCTCACTCTTCTCGGGCTGCTCTAATAACCAGAAAAGAGCCATTCTAACATTATCGTAAGCCTGACTGATCTCTGCCAACCTATCTGGTTGCGAAGAGGACTGAAGCCCAAAGGGCATGATCCTGTCAACCAGGTGCAGATAATACCTCGCATGCGCTAGCTGAACCTGGAGGAGTCTTCCTGTGGAGGTCAAGACCTCCAGCCCATATTCGCGCAGCAGATCGGGCAGAACCAGGTAACTTTGCCCATTCTGCAGTTCCTGCCGCTCCACAATATGGGCCTCGATCAAGGAGGCAAGTCCGTCGAGCACCTGTTGCTCACTGCATCCCATGGCCAGAGCAACATCCTCAAGGGCCTCAAATGAACAACTTCCTGCAAAGACCGCCAGATAGTGGAAGAGATGCTGTCCCTGCGAAGAGAGCAGCTGATAGCTCCAGGCAATTGTTTGTCGCATACTTTGTTGATGCTTAGGCAAGTCAGTACTACCCCGTGTAAGCAGAGCAAGGCAATGTTGTTGGAGCCGCATGATCAATGCTTGAGGGGAGAGTGTCTGAAGCCACCCGGCCGCCAGTTCCAGGGCCAGGGGAATCCCTGCGACACGTGTGCTGATCTGCGCCAGAGCTAACAGTTGTTCATCTGTAAGCTGGTAGGAGGAGTCTACGCGTTGGACATATCCTAGTAAAAGTTGCACAGAAGGATTTTGAAGAAGTTCTTCACGCGTTGGGTCTTGGGCCAGATCAGGGACGGCAAGCGGAGGAACCACTAAGAGTTGTTCGCCGCGCAGTCTCAGGGCAACGCGGCTAGTCACTAACACTTTCACCTGAGGTGAGAAGAACAACACTTCCGCGAGCAAAGGAGCAGCCGGCAGAAGTTGCTCAAAGTTATCAAGTACCAGAAGCAGCTGCTTATCCTGGAAATACGTTTGGAGTTGTTCAAGCAGTGGCTGGGTATTCCGATTGCCCAGTCTGAAGTGTGCCGCAATTGTAGGAAGAAGCAGCGTTGGGTCCTGAATTCCTGCAAGCGGCAGCAATGCGAGCCCATCTGGAAAGTCCGCTGCGAGGCGAGCGGCAGCCTGCAAGGCCAGGCGTGTTTTACCTACTCCTGCCTGCCCGGTTACGGTAAGTAGACGCACCTCGGATCGTTGCAAGAGCGCGGCAAGCGCTTCCGGCTCCTGCCATCGTCCAATCAGAGGAGTCAAAGGAACAGGCAATGGCTCTCCTCGCTGTCTGGGTAGGGCGAGAGAGGTCTTTCCTACCTCCAGCTCTCCATGAGCTGCTCGTTTTCCAGGCAAAGAGTGTTCTGTTTCTTGTGTGCTCCTGGGAGCTTGGTTTTCTCTCGATGAAGTGTAAGCATCCATCAAGAAAAAATACGCTCTTACGTGTCGTTTTTTGGGGGTGATTTTCGCCATGGGAGAAACGGCATCAAGCTCGGGAACGAACAAAGCTATCTGAAGAGGGCGGGAGGCTGCTGGTATAGCTATCTTTAATGCCCTTCTAGGTTTTGCTGCGCTCTTGCAGGCAATCACACCTTCTCTTGTGTCGCACATCCAGCAAGGGTCACTTCAATCCGATTATCGTGGTACACAGCCCCCGAACCCATATCGGCGTCACGTTCAGCTACTGTCGCATTGACATTGGAGTCACTTTCCGACTGCCCAGGCCAATATCCTTTAGTTGTGGCTGCAACCCCTGGTCGCACATGATCGCTCATATCAAATCTGTTTAAGTAGTGTCTAAAGAAGCAGGCCATCAATGAAAGGATGTGCAACCCCGAATCACTTCAGGATGAGCTTGTAACCAGCGACAGCGCTCGGCCTCAACGTCTTACAGTTCATCAAGCGAACGGAAGATCCGATTGGCGAGCGGCTCGTTGGTAAGCGGCCACAAGCGTTCTGCTGGTTGGAGTTCAGGCGAATGCGGGGGCAAAAACAGCAGATGCACGCCTTCGGGAATCTGGAGTCCGGCACTCTTATGCCAACCAGCCTGATCGAGAACCAGAAGAATGTGCTTGTGTGGTCCAACGCCCTGTTCCTGGGCAAAGGAGGCCAGAGCCAGAGAAAAGGCTGGTGTATTCACCGTAGGCAGAAGCGCCCAACTGGTTGCTCCGCTTTGAGGCTGGACAAACCCATAGAGATACATCCACTGATAGCGCGGTCGCACCACGGCCTGCACTCGGCTGCCCTTGCGAGCCCAGACCCGACGCAGGATCGGTTTGAGGCCGATGCGATGCTCATCCTGGCTCCACAGGTCAATCTGGGCTTCTGGATACTGCTCTCGCAGCTTTTCGACCTCCTCTGGCAGTTTTTTTCAACGCCTGCTGGGCGCCTTGGTCGCTCTGCTCATGCTGCGGGCGGAGGACGCAAGTGCTTCTGCCTAGTCGCTGCAAGTACTCCCAGCCAAGGCGAGGGTCCACCGGTCGTCCTAGACGCTGCGCCATCCAGGCCGCCACTTTGGGACCGTTCCACAGGCCACCATCAGCAGGCGGCTGATCTAAGGCGTGATCAAGTTCCTGCTGTTGCTCGACGCTCAGGAGGCAGGGAGCGCCTTTCAGCGTGAGCCTGTGGTCAACAATGCCTTGCTCTCCAGCCCTATTCCAGCGCTGGACTATCGTGCGAACCCACCTGGCTGTATAGCCGAGCAGGGATGCTATTTCGTCTGGCGTGTGGCCCTCCTTCATCAGCCACAGGATATGCCAGTGGGTCCGCTCGACAGAATTGGTGGCGCTTCGATAGTGGTCATGAAGCTCTTGTGATGTGAGGTCGGCCTGGACTGTCACGCGTTTCGCCATACCTTTAGTATATTACCTAAACGGATTTGATACCACTGGCCTGCGCGCATCAACGACAGCACGTAAGCAAGAAACAATTGAGCGTCTACGTGCCGCCAATGCCTCACTCAACGAGAAAAAACAGGATATTACCGCGCAGAGCGTCTACGCTGAATGTGGTTTGCATTACTCCTCGTATGTCCACAATGAGGATGCTATCGCGCTGTTCCGGGCCAGCAGCACCAACGAACCAAACGCAAGCGAAAAACCAGTGATGATACATCTTCACTGCCATCCCCTCGTGATCGGTTGCTCAACTACAAATAATCTCAGTTAGTCATGCGCTTGCGAAAGGCGCAACAGGAGATCGAGGACCTGCAACAACAACTTGCCACGCTGGCTAATGCATGTCTACAACGTGATGCACGGATGGTAGAGCTAGAGGCGAAGTTGGCGGAACTGGAGCCGTATCGGAGCTTTGTTGAACAAGTACGCGTGCGCATTCGGCGGCGGGAAGAACATGAGCAGGACGCCCCATCCTCGTAGTCCTCAACTCTTCCCTAACGTTTCTCCTGCACTCGGGTAAAGAAATGATCAGCAGTCCCAAACAGCAGAGCCGATCCTGTTGCACTCATCCCAATGATGACCCCATGAGCATCTTCTTCAAAGGTAATCTGGAACGGCAGTGACTCAACAGCAAATATATTGTGTGATCGCGGAATGAGTCTCGTCCTTGTCCAGACCTGTGGCATGCCATCGACGATGAGATGATCCTCTTCGAGCAGAATTAGACAAGCATGTTGGCCTCCATCTTCCTCAAAGGAGTATGTTCCAACAAAGTGCTCAAACTCGGAAGATGCAACGGCTGCCTTTTCCTGTGGAGGGAGGCGAAGAAATGTTATGACACTCTGTTCGTACGTCGTCCAGGAGCCCGCCGAATTCTCTAGAGCCATCTTAGAGGCATCGAACTGGGAGAATGCCGTCTCGATGAGGTGACGGAAATCCTTCCAGTAGGTGACCATTCCATCAAATCCCTGGAGTTGGCGCTGCTTTCCATAGGATGATTGGGTCGCACCTGCAATGAAGCGAGATTGTGTCTCACCACCTCTCCTCTCACAAATCTTCTCAAGCGCACGCGCCACATCTTGTTGATACAAGTAGATGAGGCAGGGGTGAAGAGGATGGAGAATCTGTTCCACCTGAGAAAGATAGCTCTGGATCTCGTCGGCTGGAACGTTCAGTGGGAACAAGCTCCAGGTGAGATAGCCAAAGAGACATCCATCGAGAATCACAATGGTCTCCGAGGATTGAAGTTGCTGTGAGAACTCCTTCCATTTCAGCAGAACAGCCTCTATAATCTGATGGTAGCCCCCAGCCGTCAGGGTATCAATGGTCTGCTGCAAGGACGCATGATCGTGAAAGACATAGAGTGGATGATCTTTTTCTTCCTCGTACCACCATCGGCAGGCAATCCCAGAGCGTGTGAGAGCATGGGTGACGGATTGTGCCAGGGTAGACTTGCCGGATCCAGGTATTCCTTCAATCAAGATCAATTTTGTATTCCGCATGCCGCAACTCTTTCAAAAGCAGTTTTGAGGATCTCAGAAGGGTCTGTCCTGATCCTTCTTTTGCCTTTTTCATTATCCATGCCATCAATGAGCACGTCAATCCCGAAACCTCTCACCAGCCAAAAATGGAGAGGGATATCCTCTGGGCAAAGTGTCACGACACACGCGAGTAGCAGATGTTCGTCGGACGACGTAAAAGGAGATAGAAAGCAGGGAGAACCAATACAAACTGTTTACTCCACCAAACTGGGCAACTCCGAGAGAAACAGGGCCTCTGCTCATGGCAATGGTTCGCCGATGGATCAGGTAAGTCCGCAAGGGTTCGCCTGTGATAGCTGAGTAGGGAACGACGCACTCTCGGTTTCCTTTGGCAACCTCGGCTCGGATGCGCACCATGCGCTGAGATGGATCGAGATCGTCGCCTCGCACAGAACACACTTCTTCGTGGCGGAGCCCTGCATCATAGGCCAGGGCAGCCATACAGCACGTCCGCAGCGGAGCTTGCTTGACCACAGCCAGAAAGGCCCTCCACTGCTCATCGCTCGCAATCCACAGCATGGTATAGAAGCGGGGCAC

Protein sequences of DBSCAN-SWA_4

>CP035758|3448468:3500639|3492878_3494351_+|QBD77342.1|DBSCAN-SWA
MQAAQIPMHVSPWPTLLKFDHQVPILNWTYPFTPYEPPMPDPFSIYKQIASKPRRRALYLHVPFCDTICSFCPFTRGPFQGTDELDLYVQALLREIEIKHRHPTIHSTPVDCIFFGGGTPSVLRAEHFYQLGEALHRSFDLSRLKEFTIECEVKSVTLEKLKAFEQIGVNRVSFGVQTFNSLYRELFTMTATVDQIRRVADWVNERFPLTGVDLIYGMAGQTLDDFVTDIDLIKELGTRTIDFYPLNNCSSQLRLHQAFAKHGLKPLSANTKLSYRMFLNEYMRAQGYVPHNGHSFTRNIAPADHPRVVVQRNGATFLYHDLFNGYAEDFIDGYGASAASFFGSQLVYNVKSRKQYMDRLLGGEERAWFHAYNGVKVAGKGIVAFPYRGVLEKANIDWNNVDPETRAAFEESVVQGLAADRGTSYEITETGWLMYVNYMYALMPRQDQRRYTKAVIRYLSDGRPIEEMAFFPTRSKRASIPIRVGATELR
>CP035758|3448468:3500639|3451814_3452369_-|QBD77307.1|DBSCAN-SWA
MTAVLDNLAELYRYQGKYEQAGIYLHRSLAIYEKHLGPENLSTSAGIISLGIFYQTLGNYDLAETLFQRALAIRERHLGSGHQSTAQCFGHLAILYRGEGSYSKAEPLLQQAVATRERLSGPDHPATGLALHSLALLYQRQGKNKQADALYQRVLAIYEQHLGKTHPRTLRVKNDYEHALEKHL
>CP035758|3448468:3500639|3456229_3457549_+|QBD77312.1|DBSCAN-SWA
MASWRNVLNPSLAAAAVAAAKDVAFRLQDPELLQRAINNIRQQTQTSVYDTDPAASCYAGHAGAALLFSELDRRFPTEGWDVAGHHCMQVAVCSVKRSSWSPRRLGLGALSGLLFVTWSLSHGETRYLRTLTALEQQALPAIRTVAENVIADQVHGCTESLYDHISGLTGMGVHLLCRRHVPAVTETLEAVLQALIYLAEETDGIPHWYIPSYLSDPGWLSKFPHGHLNCGLAHGIPGPLALLSLAKSSGIHVPSLDMTIRRIADWVVAHHRADTWGIDWPNASPPGDAPVESGTTRTAWCYGIPGVARALWLAGKAVDCTTYRDVALLGMRSVYRRSVEARRLDPSGFCHGIAGLLQITLRFAAETGDTCFIEPVNTLCEQMLANYEPETLLGYRARRIGGDLLDDPGLLNGAAGNALVLLAASTPHEPTWDRFFLLS
>CP035758|3448468:3500639|3476763_3477660_-|QBD77329.1|DBSCAN-SWA
MPTLVPADLVLAAIARLRQLLDCSQMSNDAVSQRFGPVMRQMADQHLRDLIPKKDEGQNLYTHLSRSIYGRLCVLYHCPPAVFDLQYMAHILGHYWYFREQDEKKRANLDSTLHYMDYVIGDGHGNLDGRRGIWLGTKPGVEVLDAFRKEWEEMTQPPVIRTGHSGKKKEPMGEQHPVRPKKRSILNCLPQQKTLFDAEMERRSLAHQHELVGALLNEAAWYRQMDAELSPLSEALQASTPLGTLRSLIAVYQGEKQDVAVSTHLQQRWGCRLTRSMRSLRRPSRMAIRSLSNTLRAP
>CP035758|3448468:3500639|3450372_3451446_+|QBD77306.1|DBSCAN-SWA
MTIHSEVIGSLLRPAYLLEARRQVETGQISAATFKALEDRAVDEAIGLQEVAGIEVITDGEMRRASFFGHLVDALEGFDPSGGRRLPMKDEEGGQFFAPTPVVVEKLKWRRSMCAEEWVYLRARRKGPLKVTLVSAQPYYDPQKSREAYPSYDAYLADVVEIARREVQELRRLGCSYIQLDAPQYASLLDPDIRAALRQRGIDPDKSLDLQIACDNAIIDAQPGVTFGLHICRGNNQSKFYASGDYEPIARVFRQTRFQRFLLEYDDPRSGGFEPLQHVPQDRFVVLGLVSTKRPQLETAAQLRERIEQAARFFPLEQLALSPQCGFASTMEGNSLSPQDQQRKLKLVAQVARQVWG
>CP035758|3448468:3500639|3449720_3450026_+|QBD77305.1|DBSCAN-SWA
MKFRFLTLSQHTPRLLALGLCAILLLTGLAVFAVTGPNPDGIRVNGIKVSNPDAVRINGIEASNPDGIRVNGIEASNPDGIRVNGIEVFTSGTAYPTSIEA
>CP035758|3448468:3500639|3466323_3466647_+|QBD77320.1|DBSCAN-SWA
MSGASELQWQQDKPWDLFGSDIACDEFPPDTRGVRVNAARLDNRRDGVQALLKEWSRVATVVSTRTDPRTTTPRIAPRRPVARRSCYRAEAKHCSSALLVAGRSAMS
>CP035758|3448468:3500639|3482055_3482304_+|QBD77334.1|DBSCAN-SWA
MELPIPISKHCFLAFRSWRPDPWRKQRQDCWDSPPESIRESVRDYLLQQLHCKVRRYGMYEMVRLSVQSPSTVRTTSSSRLS
>CP035758|3448468:3500639|3489210_3489402_-|QBD77339.1|DBSCAN-SWA
MMNIESIIQAWKAEEEARDGWTSLMPALPVGEELTEQELEEVVGGFCGQHAFTGRQCADGQEW
>CP035758|3448468:3500639|3498481_3498832_+|QBD77347.1|DBSCAN-SWA
MRSAWTVTRFAIPLVYYLNGFDTTGLRASTTARKQETIERLRAANASLNEKKQDITAQSVYAECGLHYSSYVHNEDAIALFRASSTNEPNASEKPVMIHLHCHPLVIGCSTTNNLS
>CP035758|3448468:3500639|3463094_3463973_-|QBD83485.1|DBSCAN-SWA
MKDRVALNSILAAKENGELKDDGIIIESSSGTLAIGLALVGRTLRHEVHIVLDPRVDALTLAKLRTLGAIVHMVEQMTEGGWQGTRRQKVLQLMEEHPGAFWPRQFTSIQNPLSYTQLAKELLEDVNHIDALVGPVGSGGSLCGSARFLRKFLPDLLVVGVDAVGSITFDQPDLKNRLQSGLGNSIISENVDKTLIDQVHWLNDEEAFNATLQLAASEQIFAGNSSGSAYLVACWLSTQMPLESTIAVIFPDRGDRYFRTIYNPDYWRDHNLTRRCISPDPKEVPYGTIVKE
>CP035758|3448468:3500639|3473758_3474298_+|QBD77326.1|DBSCAN-SWA
MGEMTRWQHECLFAAGGLLDRLRPLGVTEEREIERLCQEEIAAWRARPTMVVESSLQEPLRHARNAIREHLPLTGANRWKNPKTKKYEHIALKYLNFSLEEWQRINTDSEERFAQRIRSQQRIDDPDAVVCLSEDLLRRPEWYNLALGVTINTGRRSTEVLKTGVFSPKTAYTLWFKGN
>CP035758|3448468:3500639|3461945_3462239_-|QBD77315.1|DBSCAN-SWA
MLSLDEGARYLGEFAFGNNPRVMRVIHNTLFDEKMGGTVHLALGDSFPEAGVVNRSAIHWDIICDLRLEGEVWVDDTLFLKDGRLLLKTEALGRCQI
>CP035758|3448468:3500639|3465227_3465578_-|QBD77318.1|DBSCAN-SWA
MFPPRSHICPPRLLPPTGGQVTSSVEDELMHGTNTGTTSRWISSLLTGIPAISFGTLPIFARLAYAAGATPTTVLLLRFALAALIMVGVMRVRSIPFPRGPALLGLVLMGGVGYVG
>CP035758|3448468:3500639|3488438_3488648_-|QBD77337.1|DBSCAN-SWA
MNIESIIQAWKAEEESGDEWSSSIPVIPVGEELTEQELEEVVGIGGVCTMCDQWFITISPVSHPGQTQA
>CP035758|3448468:3500639|3485182_3488299_-|QBD77336.1|DBSCAN-SWA
MPLSLSDLYAMMGIASGTSAADQELSGKRASLPNWTNTLQDVLRLVEMMAGESVMLEKRQWSFLDLSNPSPFEEILAPFIGVAQQRYMDQAGAAAYLLTEKAHLSLQRSLLQILTSLSIQALHTAFQAYAQGYWRSAGRLDTIGKASANEEMVYQRFIEQMYAGGLITFLRKYYVLAQLLATTVDLWVNAHIEFLQRLAADWQDIQQIFGKDTEIGNVITIQPTLSDPHTGRRCVMALQFASGLKLVYKPKNIGLEAGYYDLLNWCNMQGLTPPMKILPILKRVEYGWVEFVQQEPCQDFAATQRYCQRVGMLLCIVYLLGGTNCFHEHLVAHGEYPVLVDPEVLLHTSPCFDSQESALQAQSFDWEQASYSVLHTGLLPTWQQAEKPSAGGQYSDISGFAMAARKKIYAQEDALTLPFRQDMILAYGSLKPRPRYNTAMYRGCPLQLEEQSNEVSNGFRRMYQLIFHYRTALLAEGSSLLALHEQSVRVISRAPREYRDLLPKLLTPQALSDQNRRHFLLKSLENMGGAAKDSLWQAIIEAEKRALLQGDIPVFRLPVEKNLPLVAHMQAGPFRLHQSAFDLLQARLNSWCEADMQFQLHLLQRALRRDITSGVVSSVPRKATEDGPASAGELNLDFSDILLPHAWKIANDIAMQAIPLGDGGVTWVGAQFLKCARCHQLRSMGFSLFQGTAGIALFLAAIAKISEDASYLKLVGAALQPIQQMLHGNGQLLAQEMGIGGAVGIGSLVYTFTRISQLLDDARFLASAQDVARLITAEEIAADRRLDIVSGTAGALLGLLALHERTGDQWVLDRAILCGKHLLQTRTMSAARCQVWPTYGGTHHTGFSHGVAGIVYALLRLYAVARDADLLDAAREGLIYEDGAFRPEVENWAEELGERASKSWMTWCHGAPGIGLARIGGLPLLASPQIQRDIEAALQTTKRFGVQAFDHLCCGNSGRTELLWTAALHLKRSDLAEIAQQHIVRMIIKAEQRGAFALPTFLPAWASLPHFFHGTSGIGYTLLRMLYPELLPSVLLWE
>CP035758|3448468:3500639|3455477_3455867_+|QBD77311.1|DBSCAN-SWA
MSDLIPPGNCLGTYYHRYSFPHPTFQEYLTARYIAAQPNPDYIDMVMAHLHEDWWQEVHLLTIAHLGSGKSGNACDSDTQLWWSPPGITGESVEPTPVITRTRGRGKTFSGCLLHRRNNRSLRFMHQLS
>CP035758|3448468:3500639|3488902_3489088_-|QBD77338.1|DBSCAN-SWA
MMNIESIIQAWKAEEEQSNEWVSLMPALPIGEELTEQELEEVVGGQCGEESVTVCRAGGDW
>CP035758|3448468:3500639|3497250_3497439_-|QBD77344.1|DBSCAN-SWA
MSDHVRPGVAATTKGYWPGQSESDSNVNATVAERDADMGSGAVYHDNRIEVTLAGCATQEKV
>CP035758|3448468:3500639|3473216_3473450_-|QBD77325.1|DBSCAN-SWA
MQVYWIKSPSEITPAVVKRQGRTYTWIAVFNHEKDQVEYLHIEKQSLQPRHVQDEIDEREATEVQQRTTRKRILGHH
>CP035758|3448468:3500639|3464409_3465219_+|QBD77317.1|DBSCAN-SWA
MVNDRAIKVFYFCVPADELYCQRLEMNLVILKRHGAIQSWASNITTDPSNLIDELKTVDIVLFLISPDFLAADHNFRADFQIILEHQNDRRIYAVPLLVRPVYMEGSPFSYIESLPTGSKPIAKWKNEDEAWVNVSWGISKIASHLQAMRRYERSHPSLAPAPIDPFTVAAAGTAIAQVILMVSDMWSRRERKGEEHKQDEVKEVRVLTGSGQWVHFRSTEQAGGAWNQVQKVRALMSDNHWIELQTEDELQYRSSTTTPAKVRVRAVK
>CP035758|3448468:3500639|3497976_3498516_-|QBD77346.1|transposase|DBSCAN-SWA
MAKRVTVQADLTSQELHDHYRSATNSVERTHWHILWLMKEGHTPDEIASLLGYTARWVRTIVQRWNRAGEQGIVDHRLTLKGAPCLLSVEQQQELDHALDQPPADGGLWNGPKVAAWMAQRLGRPVDPRLGWEYLQRLGRSTCVLRPQHEQSDQGAQQALKKTARGGRKAARAVSRSPD
>CP035758|3448468:3500639|3448468_3449101_+|QBD77304.1|transposase|DBSCAN-SWA
MAQQKENQPPSQEQQQLSPSTVSGASSEQGNGASSFPVTSLGLEGYAKALERLDGITGVNRRIAEIILAEIGINMDQFPSDGHLASWAGMCPGSKVSAGKRLSGKTTKGSPWLRSALVEAAHGAARSKGSYLGEHYRRLARRIGKRKAIIAVAHSILVIIYHILKEEKTYQELGSTYFEEREHDAVKRRALRNLERLGYEVALQEKEQAA
>CP035758|3448468:3500639|3499055_3500063_-|QBD77349.1|DBSCAN-SWA
MRNTKLILIEGIPGSGKSTLAQSVTHALTRSGIACRWWYEEEKDHPLYVFHDHASLQQTIDTLTAGGYHQIIEAVLLKWKEFSQQLQSSETIVILDGCLFGYLTWSLFPLNVPADEIQSYLSQVEQILHPLHPCLIYLYQQDVARALEKICERRGGETQSRFIAGATQSSYGKQRQLQGFDGMVTYWKDFRHLIETAFSQFDASKMALENSAGSWTTYEQSVITFLRLPPQEKAAVASSEFEHFVGTYSFEEDGGQHACLILLEEDHLIVDGMPQVWTRTRLIPRSHNIFAVESLPFQITFEEDAHGVIIGMSATGSALLFGTADHFFTRVQEKR
>CP035758|3448468:3500639|3454615_3455125_+|QBD77310.1|DBSCAN-SWA
MKRILLTGMSGTGKSTVIRELAARGYKAVDADSDEFSQWVEIEGEASAEVTPVDGNRDWVWREDCIQDLLSTEDTDVLFVSGYAENMPTFFPQFDLIVLLSAPASVIVERLRTRTTNQYGKRSEEVARVLSLVESIEPRLRCAAGYEIDTRIPLSEVVATLLQLVQSQP
>CP035758|3448468:3500639|3483073_3485149_-|QBD77335.1|DBSCAN-SWA
MKKEGKKYMETDPIFPLEDTSSGIEGVRWYQATTLTERIASLPLEERLHFLKSQEITEQALKKLKRWKEQKPFKKGRLFSDRLAMDALSEQELCALLAEPGEALYTRLSQREPPDWLVALKQALATEVSPTTMRRFFTDVEPERGAYRILYPFYPLLQGGVKRLQKLIRELFEQYHHLPFEPESLLSLFLPHLFRQWIARLNRAVVLEMHIARLRGLLLGETPEERFQSYIERLSQPEHLLNFLEEYCVLARQLMITLDLWVEGRIEFLRHLCQDWEEILTTFFLEQNPGQLTEVQAEVGDLHRHGRSVMILTFRSGWQLVYKPRSLSIDIHFQEVLSWLNTYGNHPSFRPLKLINYGTHGWAECVSAAACSSEEEVISFYERQGGYLALLYVLEASDFHYENIIASGEHPFLIDLEALFHPRVSKESITALQRPAQQALDHSVMRIALLPQRFWSNDASKGVDISGLGNPEGQLSPRPVPRWEGLGTDEMKVIREQVKLQGGKNCPKLAGKYVQASEYIECIERGFVAIYRLLIEHREIFLAKILPRFAHDEIRFVARPTSSYGHLLTESFHPNNLRDALRQERLFDRLWMAVEFQPSLQRLIPAERADLLRGDIPLFTTTPSSRDLFSSEGKSIPRFFPESSISQARKLLTQLNEEDLQRQICLIRAAFASTIDDFTAQPDHSTRPSGS
>CP035758|3448468:3500639|3479801_3481346_-|QBD77333.1|transposase|DBSCAN-SWA
MKQERRVPSLTELTEEQRTEAYRRYEVVKECVEEGVPQTEVAREYGVPLSTLQRWVHQYREDGLCGLARQPRADRGTRRNLSEEVVKVIEGLALRKPRRSMATIHRQVSAIALTQGWEEPSYAQVYRIVKALSPALVTLAQEGAGSYREEYELLYRREAGRANEIWQADHCLLPIWVKDGQGKSARPWLTVIEDDKSRAIAGYRFSWSAPSAIQTALTLRQAIWRKEDPQWQVCGIPEVFYTDHGSDFTSVHLEQVGADLKMQLVFSQVGRPRGRGKIERFFQSVEQLFLERQPGYAPSEAWPKSVGQGAGKERAGVLTLWELEQCFREWLLSDYHRRVQKGHSRGPQERWEEGGLLPRMPESLEQLDLLLVQVARKRRVQQSGIAFEGYTYLDPTLSAYVGEEVMIRYDPIDLAEIRVFFQNRFVCRAICPELSGQTVSLKEIVAARQARRRDLRGELAERKALVKHYVKREAETSRRATAEQAVGEKAAAVKLEVRQPRCRSKRPLCQRKRV
>CP035758|3448468:3500639|3478541_3478775_+|QBD77331.1|DBSCAN-SWA
MQVYWIKSPSEITPAVVKRQGRTYTWIAVFNHEKDQVEYLHIEKQSLQPRHVQDEIDEREATEVQQRTTRKRILGHH
>CP035758|3448468:3500639|3462251_3463055_-|QBD77316.1|DBSCAN-SWA
MPVLYDGLNTLVRYCLSVQQGERVGIESCPLTAPLIEAVYQEIIRAGASPIVLLSLERLDEILLRDGNNEQICQSTRLQEVIAEEVDALLVIRAEENSSGLNAVNPARILLRREATDNIYARRKQARWTLTRYPTNALAQNANMSLNDLEEFAFDACFLNDHNPIQCWQKLGTEQQRLIDWLAGRKQVHILSGGTDLTLSIEGRRFVNGDGRRNFPSGEFYTSPLDQSTTGIIHFDIPSLVYGHLVEGIRLVFQRGRVIEASATPGQ
>CP035758|3448468:3500639|3461090_3461891_-|QBD77314.1|DBSCAN-SWA
MIESLDHYLSVKHTLHLEQLKQFLTIPSINTLNEFKDDIHRCAGWVAEHLRDTSFEHVQLLETRGHPIVYADGLHAPGKPTVLVYVHYDVQPVEPLELWESPPFEPTIRDGQLYARGASDDKNQVFMHIKSFEVIFATASNLPVNVKFCIEGEEEIGSEHVTQVLQQQQARFAADVVVISDTAILGPNQPAVCYGLRGLVAFQINVKGAGTDLHSGSMYGGAVQNPIHALVELLSTMRNLDGKVTKEIFQRKHHPTKEEFPEANGS
>CP035758|3448468:3500639|3470646_3472212_+|QBD77323.1|transposase|DBSCAN-SWA
MKQERRVPSLTELTEEQRTEAYRRYEVVKECVEEGVPQTEVAREYGVPLSTLQRWVHQYREDGLCGLARQPRADRGTRRNLSEEVVKVIEGLALRKPRRSMATIHRQVSAIALTQGWEEPSYAQVYRIVKALSPALVTLAQEGAGSYREEYELLYRREAGRANEIWQADHCLLPIWVKDGQGKSARPWLTVIEDDKSRAIAGYRFSWSAPSAIQTALTLRQAIWRKEDPQWQVCGIPEVFYTDHGSDFTSVHLEQVGADLKMQLVFSQVGRPRGRGKIERFFQSVEQLFLERQPGYAPSEAWPKSVGQGAGKERAGVLTLWELEQCFREWLLSDYHRRVQKGHSRGPQERWEEGGLLPRMPESLEQLDLLLVQVARKRRVQQSGIAFEGYTYLDPTLSAYVGEEVMIRYDPIDLAEIRVFFQNRFVCRAICPELSGQTVSLKEIVAARQARRRDLRGELAERKALVKHYVKREAETSRRATAEQAVGGESGSSEAGSSPAKMQEQEAPVSTKTRLKRYRNE
>CP035758|3448468:3500639|3476524_3476851_-|QBD77328.1|DBSCAN-SWA
MSLDQIDALFEKAVEDGYKEPLKYFEGTLEKRESYKAGAQKRAQKYQQTDFTLLPYSQLEHIRMPEAAQERVRRIVLTIMRTMNGPNPVIVGISMLDSSTNSKRSAMS
>CP035758|3448468:3500639|3497552_3498029_-|QBD77345.1|transposase|DBSCAN-SWA
MPEEVEKLREQYPEAQIDLWSQDEHRIGLKPILRRVWARKGSRVQAVVRPRYQWMYLYGFVQPQSGATSWALLPTVNTPAFSLALASFAQEQGVGPHKHILLVLDQAGWHKSAGLQIPEGVHLLFLPPHSPELQPAERLWPLTNEPLANRIFRSLDEL
>CP035758|3448468:3500639|3472204_3473044_+|QBD77324.1|DBSCAN-SWA
MSKAKTKELMGPVAREGVVVWEGLGEEQEEEEVHRRLWKRFVQTKEYGRFVEFCEECRASRYIGVCYGAAGVGKTESAKEYARWDEIEPLLSWHGVVQPRLSPENPRPTVALYTPTATVTARQIEKDIALLRWSLRVIGEAARAVPQEVETVEGMVRPGQVDLLVVDEADRLKPQAVEVLRDVYDRSPTGLVLIGMPGLEKRLAAIRNCIRGWVLSINIGRWEKKNSRSLLNNRCALLAEEEVREEDREGGSGADYSYDGREFSADGTVALANETDHRD
>CP035758|3448468:3500639|3498834_3499041_+|QBD77348.1|DBSCAN-SWA
MRLRKAQQEIEDLQQQLATLANACLQRDARMVELEAKLAELEPYRSFVEQVRVRIRRREEHEQDAPSS
>CP035758|3448468:3500639|3477692_3478232_-|QBD77330.1|DBSCAN-SWA
MGEMTRWQHECLFAAGGLLDRLRPLGVTEEREIERLCQEEIAAWRARPTMVVESSLQEPLRHARNAIREHLPLTGANRWKNPKTKKYEHIALKYLNFSLEEWQRINTDSEERFAQRIRSQQRIDDPDAVVCLSEDLLRRPEWYNLALGVTINTGRRSTEVLKTGVFSPKTAYTLWFKGN
>CP035758|3448468:3500639|3467094_3468405_-|QBD77321.1|DBSCAN-SWA
MPKPIDDPALHLRLIGGFEQAKVTRRDQIVIRTAYEAGARITELLTLTVGDWRKRGGKQEATACNKESHGRRVKIIRFSMETAKLLHRYVNEDRVRVDPHHRTLAQLRDHEPLFLLARHKPYSYDAFVPHWERLRRTIGVDLNIHGLRHWHVCQMMRLIHGIAETPGEVERRKEEMVRYMAWRSPETLKAYEHYFQAINHAQMQEVLHRQLDEKLKEYIRQAQQNTLLEDLTSALHTTLPRASGPSSSAGISHSIRLSLFHPLFPRSFESSFALSLRRFLWRSLRERAVSIHLLLFISSFTYFITSYHSLGSAISPSSIFSIYTNPMSGTKCTGLIRDCLSGKILLARALLSGTQGDLSALLMEVKNQLPVPVKGVISDGQETIRSAVAFVFSQIPHQLCQLHYLHDAAMLIFEADRHAKTELKKHVRGNRPIERA
>CP035758|3448468:3500639|3469064_3469634_+|QBD77322.1|DBSCAN-SWA
MPALAPKSAVRYRPVDPDVATEEPPRIPRASRTQPTSKLPERRQCPLSCQPLWLLPVGVGMILMLFIVIAGSVVLGWVQTASDDLHYGRPRTFQMDAFVGHETGSTSSHFIALNLQGKIEIIELPGGDPTRARMYVGPKIYGPGADLVPVTLRFVEGAQPHHPEMLILFQNTQVVFRNANGTFAPATHT
>CP035758|3448468:3500639|3452767_3452962_-|QBD77308.1|DBSCAN-SWA
MTTLLRLLPPGLSFEKVEQTNVAAADLLRLCAFLHPDAIPEEIIVKGAPYLGKHLDLWRLTLCN
>CP035758|3448468:3500639|3457578_3460800_+|QBD77313.1|DBSCAN-SWA
MHSSTRTFSPTELLTSHAVRYTPLDFIQVRAPLFPIEAYLSLQQPSAVAASGLHPQNPLVRRALAIGSIDFLEELDRQASSPRDRDRWERKLLRYLIRMATRPTPYGLFAGVSLARWGEQTNVQIANRPRILFSRPDLNWLLPLLWELETLPEIRRHLHYLANRAAFVRNGRIFLQEQLALGQPNQNETVSLRATPVALLTLKLARQPISHSDLVQELLAAVPRATLSQVEELITSLWQYTLLFTDLHPPFTGQTLPAQYVVQRLENIPFAAPVATLLQNFLRALRVWDQTNDEESIERYHDLQYCAQEINTKVETLRCASQPTYLRQVKQNWAHFPSSTFVQTDSSFSLVGQQLARKIGQEIENVAPRLLRPQRPHYLQAYRMAFLERYGTDREVPLLEVMDSQIGLGVPAFALKSVSDEMGKQSERDQELSRLALMALHERQGVIALDEESLQRLALVPPSDKVRLPLSFDLFVWLAATSRQALAEEKYQIVIGPHGTYQAGQSLGRFASYLGTEAVQVLEHSAQQEAEREPHVLQAELVYTSSTPRSMNVALRPAIRRYEVIYGVVPGVSMADTIPLDELVLGVQGERFYLYWPRQQMEVRPCSSHLLQSRTAPSIMRFLSDLSLDGTYNLSPFHWGRCVHFPFLPRLQIGRVVLSLAQWSLSASFHENELCLASPEQFQETLSCWRERWRVPRYVYLAEGDNRLLLDLEQVAQAEELRSTLRARKKTQTVMLQEALPGPEHAWLEGPDGHYLSEFVVPLIRCSSTPSRERLVAHSPLPSKQIAIVNAERLKAPGSDWLFLKLYSAPTLHEELIADPLRTLVQKVFTQKLAESWFFIRYTDPDPHLRLRFRGNPSLLTSQLFQTLCSWASQLVSDGRCLKFAFDSYEREIERYGGLEGMALAEKLFDADSSAVIELLHLKRARRLTLAPQMLAVLTTDDLLASLELSPQERLHWYRQSLFNTKEVGMTYRLKSAELRALLKDTHYIQKLEGGMQLLKILNTRRICISQIAQQLSDLETQQGLMQPLSRMYASFTHMHYNRLQGINRQRERDISELALRTWMGLLGDPRTT
>CP035758|3448468:3500639|3489610_3491896_-|QBD77340.1|DBSCAN-SWA
MPQFDSDKALTLEQRQVPPASRKPKALREMARRKRSSMRSPWRKRVPVLHQLTIAECGAACLAMILTYYGRKTSVSEVRERCGVGRDGLSASAVVKAARSFGLLTRAITLKNASDLRFVPIPAIVHWNFNHFQVLERWSPGYVDLVDPATGRMRMAIEEFCRSFTGVVILLEPGALFDPSNVREQVNLRKYAANYVKQVPVAFLQIIGASLLLQLLALATPALTEVVIDHVVLSGLHDVLTLLGLGIVIVLLAQLVVSLLRELLMLYMQMHTDMRTMLRFFEHLLRLPLLFFLQRASGDLLARMNSNLVIRDLLSNQLISTVLDGSFVIIDFIILFTLSPLFSLLVLGLGLLQVAILLGTNRLVRELSYRELTAQGKTQGYMTEVLAGMMTLKAMGIEDQALERCSNLYFEQLNISARRNLVSALTNTVLVTLRVGAPLALLWFGTWQVISGTLPVGAMLGLNALAITFLTPIATLVNNSKSFQLIHSHLERIADVLEAQPEQGGKAAQLPLQLTGSIRLEGISFQYAPDAVPVLQDISVSIHAGQKVAIVGRTGSGKSTLGNLLLGLHQAGSGEVFYDDIPLKKLDFQAVRSRFGVVTQNTSLFSGSIRENVALSNPSASIDDVVRAAQMAALHDDVMKMPMKYETHIAESGNALSGGQRQRLALARALLNDPVLLLLDEATSSLDVVTEKAVEHNLSVLACTRIIIAHRLSTIRDADLILVLDQGSIVERGTHQELLKCNGYYAQLIQSQLTHNDEDGK
>CP035758|3448468:3500639|3474272_3475226_+|QBD77327.1|DBSCAN-SWA
MHSGLRAIKDEGYDLEAYEIPTLVPADLVLAAIARLRQLLDCSQMSNDAVSQRFGPVMRQMADQHLRDLIPKKDEGQNLYTHLSRSIYGRLCVLYHCPPAVFDLQYMAHILGHYWYFREQDEKKRANLDSTLHYMDYVIGDGHGNLDGRRGIWLGTKPGVEVLDAFRKEWEEMTQPPVIRTGHSGKKKEPMGEQHPVRPKKRSILNCLPQQKTLFDAEMERRSLAHQHELVGALLNEAAWYRQMDAELSPLSEALQASTPLGTLRSSLQCIRGRSKTWQSAPISSNAGGCRLTRSMRSLRRPSRMAIRSLSNTLRAP
>CP035758|3448468:3500639|3494371_3497275_-|QBD77343.1|DBSCAN-SWA
MCDTREGVIACKSAAKPRRALKIAIPAASRPLQIALFVPELDAVSPMAKITPKKRHVRAYFFLMDAYTSSRENQAPRSTQETEHSLPGKRAAHGELEVGKTSLALPRQRGEPLPVPLTPLIGRWQEPEALAALLQRSEVRLLTVTGQAGVGKTRLALQAAARLAADFPDGLALLPLAGIQDPTLLLPTIAAHFRLGNRNTQPLLEQLQTYFQDKQLLLVLDNFEQLLPAAPLLAEVLFFSPQVKVLVTSRVALRLRGEQLLVVPPLAVPDLAQDPTREELLQNPSVQLLLGYVQRVDSSYQLTDEQLLALAQISTRVAGIPLALELAAGWLQTLSPQALIMRLQQHCLALLTRGSTDLPKHQQSMRQTIAWSYQLLSSQGQHLFHYLAVFAGSCSFEALEDVALAMGCSEQQVLDGLASLIEAHIVERQELQNGQSYLVLPDLLREYGLEVLTSTGRLLQVQLAHARYYLHLVDRIMPFGLQSSSQPDRLAEISQAYDNVRMALFWLLEQPEKSEQILHTSEMALRLCTSLSGFWYMSGHLSEGRQFLARALERAATVSISTHIIALTTAAFLALFQDDYEQCVLLCQEGLLLAQKENRPALSASVLYCWSWAEANRGHLPEATRLGEQALQLNASVENQIGRALCLYSLGFLSSLQAEYPQAVFQLEESLALFRKLEDVSSQANVLLCLAESLFAAQEDLPRIQELLEESQALPVTLANTIYPTNYLVLLGELALSQGDVLRARQQFTECLAAMTRMGDKRKIAVLSVRQAEAELCEHNYTEVEALCSASLSYYLKSKGYAWAALPLEVLARSHAVRQQGRKAASLWGQAQALREQFHFPLSARERAIFAAAEAEARASVGSDTFLEAWREGYHSGCAMLEDLAPTTNLAFQSGCTPPQPILPDHLTRREVEVLRHLAQGLTRAQIAHKLIISPLTVQSHIRSIYRKVGVSTRSAITRYALEQNLL
>CP035758|3448468:3500639|3500159_3500639_-|QBD77350.1|integrase|DBSCAN-SWA
MPRFYTMLWIASDEQWRAFLAVVKQAPLRTCCMAALAYDAGLRHEEVCSVRGDDLDPSQRMVRIRAEVAKGNRECVVPYSAITGEPLRTYLIHRRTIAMSRGPVSLGVAQFGGVNSLYWFSLLSISFYVVRRTSATRVCRDTLPRGYPSPFLAGERFRD
>CP035758|3448468:3500639|3478871_3479789_-|QBD77332.1|DBSCAN-SWA
MSKAKTKELMGPVAREGVVVWEGLGEEQEEEEVHRRLWKRFVQTKEYGRFVEFCEECRASRYIGVCYGAAGVGKTESAKEYARWDEIEPLLSWHGVVQPRLSPENPRPTVALYTPTATVTARQIEKDIALLRWSLRVIGEAARAVPQEVETVEGMVRPGQVDLLVVDEADRLKPQAVEVLRDVYDRSPTGLVLIGMPGLEKRLARYPQLYSRVGFVHQYRTLGKEEQQELVEQQVRSFGGGRGEGRKIEKEAVAQIIRMTGGNFRQMERLLLQMKRIIEINPEVEQVNREVVEAAREQLVFGRGV
>CP035758|3448468:3500639|3465578_3466106_-|QBD77319.1|DBSCAN-SWA
MPLFPFQGIWPTLADNVFIAPGAMIIGNVILHEGASVWYNTVIRADLSPISIGRGTNIQDNCTLHVEANGPLSIGEECSIGHNAIVHAATIGNHVLVGMHAVVLSYAQISSDTLIGASALVSERATIPSGVLVLGIPARVVRPLTEADHRRILYGATAYATLAAEHRRMRKEGNT
>CP035758|3448468:3500639|3453429_3454212_+|QBD77309.1|DBSCAN-SWA
MKHHRPVRGALGVFWLFWVALVLSGCATALSQARSTPTAPSPRSASSPWAPPPCQTQHLLLAFGTFDAATSNEAAQFVLVNQSKQSCPLSGYPAVQLLDARHQPIRAHVRQVTQGFLYLPQVPHQFVLQAGGKAYFVVSWANLGCGKLPPGVGPPGSFASPVSFLRVTPPLNQASLLIATQWGARSVRSETLWTSLLWSRTISCSSLDDLQAEAAYFREASHCVRAFHGAVRELRERSALLLRGEPRDAREPIFAHAVPK
>CP035758|3448468:3500639|3491882_3492491_-|QBD77341.1|DBSCAN-SWA
MQRSTSSLFRKEALDYYRQSKEQNVLPRLVAPPVFLFLWILMCLFALMVVIASLGQIPIYASGSGVVLAQHSIQSKQVMQESTVLLFFPITPIHPLQLHTGARVHFHIGISEQQINGTVDIIVPEVLSPAEAQQRYRLDGRLSQIISGPSIAAFVKSAIPLPAQFYANSLVSAQVQIGSASVLSLIISKPVASTGEAYHASV

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
3443369:3443383	attL	NA	NA	NA	NA
QBD77304.1|3448468_3449101_+|transposase	IS110 family transposase	NA	NA	NA	NA
QBD77305.1|3449720_3450026_+	hypothetical protein	NA	NA	NA	NA
QBD77306.1|3450372_3451446_+	methionine synthase	A0A218MNE0	uncultured_virus	3.4e-44	33.1
QBD77307.1|3451814_3452369_-	tetratricopeptide repeat protein	NA	NA	NA	NA
QBD77308.1|3452767_3452962_-	hypothetical protein	NA	NA	NA	NA
QBD77309.1|3453429_3454212_+	DUF4232 domain-containing protein	NA	NA	NA	NA
QBD77310.1|3454615_3455125_+	shikimate kinase	NA	NA	NA	NA
QBD77311.1|3455477_3455867_+	hypothetical protein	NA	NA	NA	NA
QBD77312.1|3456229_3457549_+	hypothetical protein	NA	NA	NA	NA
QBD77313.1|3457578_3460800_+	hypothetical protein	A0A2H4PQG8	Staphylococcus_phage	1.9e-42	21.3
QBD77314.1|3461090_3461891_-	M20/M25/M40 family metallo-hydrolase	NA	NA	NA	NA
QBD77315.1|3461945_3462239_-	hypothetical protein	NA	NA	NA	NA
QBD77316.1|3462251_3463055_-	aminopeptidase	NA	NA	NA	NA
QBD83485.1|3463094_3463973_-	cysteine synthase family protein	NA	NA	NA	NA
QBD77317.1|3464409_3465219_+	hypothetical protein	NA	NA	NA	NA
QBD77318.1|3465227_3465578_-	hypothetical protein	NA	NA	NA	NA
QBD77319.1|3465578_3466106_-	gamma carbonic anhydrase family protein	NA	NA	NA	NA
QBD77320.1|3466323_3466647_+	hypothetical protein	NA	NA	NA	NA
QBD77321.1|3467094_3468405_-	hypothetical protein	NA	NA	NA	NA
QBD77322.1|3469064_3469634_+	hypothetical protein	NA	NA	NA	NA
QBD77323.1|3470646_3472212_+|transposase	transposase	NA	NA	NA	NA
QBD77324.1|3472204_3473044_+	ATP-binding protein	NA	NA	NA	NA
QBD77325.1|3473216_3473450_-	hypothetical protein	NA	NA	NA	NA
QBD77326.1|3473758_3474298_+	hypothetical protein	NA	NA	NA	NA
QBD77327.1|3474272_3475226_+	hypothetical protein	NA	NA	NA	NA
QBD77328.1|3476524_3476851_-	hypothetical protein	NA	NA	NA	NA
QBD77329.1|3476763_3477660_-	hypothetical protein	NA	NA	NA	NA
QBD77330.1|3477692_3478232_-	hypothetical protein	NA	NA	NA	NA
QBD77331.1|3478541_3478775_+	hypothetical protein	NA	NA	NA	NA
QBD77332.1|3478871_3479789_-	ATP-binding protein	NA	NA	NA	NA
QBD77333.1|3479801_3481346_-|transposase	transposase	NA	NA	NA	NA
QBD77334.1|3482055_3482304_+	hypothetical protein	NA	NA	NA	NA
QBD77335.1|3483073_3485149_-	type 2 lantipeptide synthetase LanM	NA	NA	NA	NA
QBD77336.1|3485182_3488299_-	type 2 lantipeptide synthetase LanM	NA	NA	NA	NA
QBD77337.1|3488438_3488648_-	hypothetical protein	NA	NA	NA	NA
QBD77338.1|3488902_3489088_-	hypothetical protein	NA	NA	NA	NA
QBD77339.1|3489210_3489402_-	mersacidin/lichenicidin family type 2 lantibiotic	NA	NA	NA	NA
QBD77340.1|3489610_3491896_-	peptidase domain-containing ABC transporter	W8CYL7	Bacillus_phage	4.4e-33	27.4
QBD77341.1|3491882_3492491_-	hypothetical protein	NA	NA	NA	NA
QBD77342.1|3492878_3494351_+	radical SAM protein	NA	NA	NA	NA
QBD77343.1|3494371_3497275_-	hypothetical protein	NA	NA	NA	NA
QBD77344.1|3497250_3497439_-	hypothetical protein	NA	NA	NA	NA
QBD77345.1|3497552_3498029_-|transposase	IS630 family transposase	NA	NA	NA	NA
QBD77346.1|3497976_3498516_-|transposase	transposase	NA	NA	NA	NA
QBD77347.1|3498481_3498832_+	hypothetical protein	NA	NA	NA	NA
QBD77348.1|3498834_3499041_+	hypothetical protein	NA	NA	NA	NA
QBD77349.1|3499055_3500063_-	hypothetical protein	NA	NA	NA	NA
QBD77350.1|3500159_3500639_-|integrase	site-specific integrase	NA	NA	NA	NA
3503768:3503782	attR	NA	NA	NA	NA

Sequences of DBSCAN-SWA_5

Nucleotide sequences of DBSCAN-SWA_5

>CP035758|8739719:8747922|DBSCAN-SWA
CTTACTCGGAAGCGGTCTCAACCTTATGACCGTTAGCCTGCTCCGGGATAGGGCTTTTTTCAGCTTTGGGAGTGTGTTCCTCCCTGATGAAAGCCTCTGCCATCTCGTGGGCAACATCATCGTGGTATTGTACGGGAGGAGATTTCATCAAGTACGCGCTAGGTCCTTCAAGCGTGCCACTGATACCACGGTCAAGCGCGAGCTTAACCATGCGTACGGCGTCGATCACGACTCCTGCCGAGTTAGGGGAGTCCCAAACCTCAAGCTTTAATTCCATGTTCAAGGGAACGTCGCCAAAGGTGCGGCCTTCCAGGCGGATATAGGCCCATTTGCGATCAGCGAGCCAGGCCACGTAGTCCGAGGGCCCGATATGGACGTTTTCGGCTCCCATCTCGTAATCAAGCTGGCTGGTTACAGCGTTGGTCTTGCTAATCTTTTTCGATTCCAGGCGCTCGCGCTCCAGCATGTTATAGAAGTCAGTATTGCCGCCGACGTTGAGCTGCATGGTTCGCTCCACCTTGACGCCCCGTTCGCGGAAGAGGCGCGTGAGCATACGATGGACGATGGTAGCGCCTACCTGGCTCTTAATATCGTCGCCGATCATGGGCAGGCCTGCATCTTTAAAGCGATCCTGCCAGTATTTTTCGCGCGCGATAAAAACTGGAATACAGTTAACAAAACCTACGCCTGCCTGCAGAATCTGCTCAACGTACCACTTGGTCGCCGTTTCTGAGCCGACTGGTAAGTAATTGACAACGACATCGGTTCCGCTGTCCTTAAGAATCTTAACAATATCTGATGTCTGGCCAGGAGCTTTGCTAATCACCTGGGAGAGATACTTGCCAAGTCCATCATGGGTCATGCCCCGCTGTACCTTCGTGCCAAGCTTTGGCACATCGGCGAAGCGATAGGTGTTGTTGGGCGCCGCGTAAATGGCCTCGCTAAGATCCTTGCCGACCTTGTTTACGTCAATGTCGATAGCTGTCGAGAATTCGATATCGTGGATGTGATAGCCGCCAAGATTCACATGCATCAAACCCGGTATAAAGTCATCGGGGTTGGCCTCACGATAGTAGTGGACGCCCTGAACGAGTGAACTGGCACAATTGCCTACACCGATGATACCAACGCGTACTTTTTTACTGCTCGTCATGAATGACTCCTCTGCTGGTTATCTCTGAAGTTGAGATTGCCCCGCTACGCTTATCCCCAGACCTGATCTCATATAGCATACTATAACTTGTTTTTTGCGTGTATGCTATGTGCTTGCTTACAGGCGCCATGTGAACTGGCTTACTACCTTGCTTGTTTTTCCTCGTAGGCCAGGCCTCAAGCCTGTAGGGTTTGCTGTAACCTATTGTGACGGCTGTTGCTCTTTTGCACCAGATATAGCCCATTTAGGCTGTGCTCCTCCCCATAAAGAGCAACAGATGTTACATTGTAGTGGTAGTGGTAGGGAGCGAAGAGGTTGAGTAAATATAACAGAGGCAAAAAATTTGCAACCGCTTCTATACTCCTCGGTAACACGTTTCGTCGAGTGATAGTGGTATGCTCAGTACCGAACACGTAGGTAGAGAGACTTCAATTTAAGCCTTGAGAACAATCAGTAGATAATAAAATGGTGTTGGATCTCTCATCTATGCTAGAAGTAGAGATAGAAGTGCTGATGCGACGTTATGAAAGGCAAGTTTGCTCATGGGTAAACAAAAAAGAGTCCTGGTAATTGGACTGGACTGCGCTCCTCCCGAGCTGGTGTTTGAGCAGTGGCGTGATGAGTTGCCGAATTTCAGGCGCGTAATGGATAATGGGGTATGGGGCAAACTGGAAAGCTGTATTCCAGCGATTACTGTTCCGGCCTGGAGTTCGATGATGTCGAGTAAGGACCCCGGCACGCTGGGTTTTTATGGTTTCCGCAATCGTGGCGATCACACCTACGATAAGCACGTGCTGGCCAATTCGAACTCTGTGAAGACAGACCGAGTGTGGGATGTTTTGTCGCGCGCGGGTAAAAAGGTCATCACTGTTGGCGTCCCGCAGACCTATCCTCCAAAACCAGTCAACGGCATTCAAGTTGGTTGTTTCCTTTCCCCTTCAACCAAGAATCCAGAGCGACCCTATACCTATCCTCCTTCGGCTATGAAGGAGATCGAGGCGGCTGTGGGCGAATACCTGGTCGATGTGCCTAATTTCCGTACCAACGATAAAGATTATCTACTGCGCCAGATCTATACAATGACTGAAAAACGTTTTAAACTGGTCAAGAAATGGCTTGTGGAAAAAGAGTGGGATTTCTTTATGTTTGTGGAGATGGGCACTGATCGTATCCACCACGGTATGTGGAAGTATCACGACCCCACCCACCATAAATATGAAGTTCATCCGGTTTATAATAATAGTATTCATGACTATTATCGCTATATCGATAACGAGATTGGCCAGATTCTGGACCTTGTAGATGACGATACGACTGTCTTTATTGTCTCCGATCATGGGGCCAAGAAGATGGATGGCGGCCTCTGCGTCAATGAGTGGCTGATCAAAGAGGGCTATCTGACGCTGAAGTCCTATCCTTCTAAGATTACGGCCCTTGATAAGTGCGAAATCGACTGGAGTAAGACCAAGGTCTGGGGCGATGGCGGTTACTACGCGCGCATCTTCCTTAATATCGAGGGACGAGAGCCGCAGGGCATTGTTAAGCCTGAAGAGGTTGAGGCACTGCGCAATGAGCTGAAGACGAAGTTTGAGGCAATCGTCGATCCCGATGGCGTGAATATCGGTACAACGGTCTATAAGCCCCAGGAAGTGTATAAGCAATGTAACGGCGTGCCGCCCGACTTGATTGTGTACTTCGGCGATTTGCTGTGGCGCTCTGTAGGTACTGTTGGCTATAATTCTATCTATACGTTCGATAACGATACTGGCCCTGATGATTGTAACCATGCTCAGTTTGGTATTGTAATCAAGCATAGTGCGGATGCGCATGAAGGACCTGGCGGCCGCGAGTTGCAGGGACTTCAGCTGATGGACATGGCTCCAACGATTTTGAAGGAGCTGGATGTACCTGTTCCTGCCGATATGCAGGGCAAAATTTTCTAAAGCCGTAACCTGGAGAAAGCATCCCTGGCTGTTCAGCTGGCTGGCAAGGCTCAGACCTCCGGTCTATTGAGATTGGGCCTTCCTGCTCGCTTTTCCTTTCCTCTGCTGCCTTCGTCGGGCGCTGGGAAAACGAGAGGTGGAAAGCCCCGAGAGAGGAGCTGGGACGGGGATGCTGTACAAGCTAACTTAAGGAGACTACTAATAGATGGCGAACACTGGTTTTACTATCTGGTTTACAGGTTTGTCCGGTTCAGGCAAGAGTACCCTTTCTGACGCTATTCAGGAGCGTCTGGCCGCTCGCGGGCGCAATGTTGAGATCCTGGACGGGGATGTTGTGCGTACCCATCTGAGCAAAGGGCTTGGTTTCAGCCGCGAGGATCGCGATACAAATATCAAGCGTATAGCTTTCGTTTGCTCCCTGCTCACCCGCAATGGCGTGGCCTGCATTTCTGCAGCTATTGCCCCTTATCGCGAGGCGCGCGAATGGGCCCGTAAGGAAATTGGAAATTTTGTTGAAGTCTATGTAAAATGCCCGCTTGAAGTATGCCGCCAGCGCGACGTCAAGGGTCTTTATAAGCTCGTCGATGAGGGCAAGATTAAGAACTTCACAGGCGTAGATGATCCCTATGAAGAGCCAGAGCATCCCGAGCTCATTGTCGAGACAAATAAGGAGTCGGTTGAGGAGAGCGTCAACCGCATTATCGCCAAGCTTGAGGAATTGGGCTATCTGGAACCCGAAGAAATGAATGAGGATGAGTCAAAAGTAGTAACTGACCGCCTGGCTGCTTTGGGATACCTGTAAAATTGGTGTAAAATAGCTGAAGAAGGGAAATAGAGAAGAAGGTTAGCATGACAGATGGATTGATTGCTCCTCATGGAGGAGAGCTAATTATAAATATGGCCGCTGAGGCCGAGCGGGCTGCGTTAGAAGAAAAGGCTAAGAGCCTACCAACCATTACTGTTGGCTCTCGCCAACTGGCGGACCTGGAGATGCTGGCTAACGGCGCGTATAGTCCGCTTGGTGGTTTTATGGGCCAGGCCGACTATTTGAGCGTCGTAAAAGAGATGCATTTGAGCAATGGTTTGCCCTGGACTGTTCCGATAACCCTGCCGATAACGCCTGAGCAGGCCGAGGCCATCAAGACTGATTCCCAGGTTGCTCTTGTTAACGCTGAGGGCGAGTTGCAGGCTGTGATGACTGTAACTGAGAAGTATGGCTATGACAAGCACCTTGAGGCGCGTGAGGTCTATCGTACGGAGGAAGAGGCCCATCCTGGCGTAAAGAACGTCTATCAGCAGGCTGATGTGCTGCTGGGTGGTCCTGTTCGCGTGGTAAGGCTGCAGAACCAGGCTTTTGCCAAATATCGCTATACGCCTACCCAATCGCGCGCTTTGTTCGCCGAGCGCGGCTGGAAGCGGGTAGTGGGCTTCCAGACCCGCAACCCTGTGCATCGGGCCCATGAGTATATCCAGAAGTGCGCGCTAGAAACTGTTGATGGCCTTTACCTGCATCCGCTGGTTGGCGATACCAAGGGTGATGATATTCCGGCCGATGTGCGTATGCGCTGCTACGAAGTATTATTCGAGAACTACTATCCCGCTAACCGCGTGATCCTCGGTGTCTTGCCGGCGGCTATGCGCTATGCTGGACCACGTGAAGCCGTCTTTCATGCCCTGATGCGTAAGAACTATGGCTGCTCGCACTTCATAGTTGGTCGCGATCATGCAGGCGTAGGAAACTACTATGGAACCTACGATGCCCAGCATATCTTTACCAACTTTGATCCCGCCAAGCTAGGCATCACGCCTATGGCTTTTGAGCATGCTTTCTTCTGCCGCGTCTGCAATTCGATGGCCTCAACCAAGACTTGCCCGCATGGCAATGATCAGCATGTTGTGCTTAGCGGAACGAAGGTACGCCAGATGCTGCGCGCCGGGGAATGCCCGCCGCCAGAGTTCTCGCGTCCAGAGGTGGCTAAAGTGCTGGTCGAGGCAATGCGTCAGCCCGTCTCGCAGTAAAAATTTGTAGAGCCAGCTAAGGCAGGAACCTGTTCTCATTCTGTAATGATGCGGGATGAGAATATGTTCTCGCCTTTTCTGTTTCAATAATATGGCTCACAGGCAGGAGGAATGTACATGTTAATTGCCAGGGCTCCAATGCGTATTAGTTTTGGTGGGGGTGGAACTGATCTTGAGGCGTACTATGCAAAATATGGCGGCATGGTGATCAGTACGGCGATCAATAAATATTTTTATGCCATTGTGACCACTGATGAATCGGAGGATCTCCAGGTCATCTCGGCCGATTTTCGCTCGTTGTTTCGCCACTCGCCCTACAATGATCTCTTCTGGGATGGTGATCTTGCGCTCCCTAAAGCAATCTTGCATCATTTTGGGGTTCGTCGAGGCATTAACCTTTTCATTGCCAGTGAAGTGCCTCCTGGCACTGGCCTGGGGTCATCAAGCGCTGCCGCTGTAACCCTGGTGCGGGCTATTTCAACGCTGGTTGAGCAGCCAATGACCAAGCAGCAGGTTGCAGAATTGGCCTCGTATATTGAAATCGAGAAGATGGGGATGCCTATCGGCAAGCAGGATCAATATGCGGCAGCCTTTGGCAGTTTGAATAAGATTACCTTTACCAGTGAGGGTGTAAGCGTTGAGCCCGTGAAGGTTGCTCCCGAGGTGCGGCAGACGCTTGAGAGCCGCCTGATGCTCTTCTTCACCGGCAGCTCGCGCGAATCAACGTCGATTTTGAAGCATCAGCGTAAGTCTACCCAGAATCAGGATGAGTCGGTTCTGCGGGCCTTGCACAATATTAAACGTGTGGCCGAAGAGGTCCAGGCATGTCTGGAAAAGGGCGATCTTGATGAGTTCGCTCGCCTCCTGCATTATTCATGGCAAGAAAAACGCCGTCTCGCACCCAATCTCTCAACCGGTTTTATTGATGAGTGCTATGAGCTTGCGCTGCGTTGTGGAGCCTCGGCGGGCAAAATTAATGGCGCGGGAGGTGGCGGTTTCCTGATGATCTACTGCCATGAGCATGCGCAAGAGGATGTCACGCAGGCTCTTGAGGAACGCGGTTTAAAGCGGATGAACTTCCACTTTGATCAGCAGGGCGCAACTGTCATTTTGAATACTGCTAATTTTAGTAATCTATGGGTTGAGCCCTACGCTGCTCCAACAAACTCATAAGGAAGAAGGGTACGCATCTTGGAGTCGATAAGCATTTACATCAGTGAACTTGAAGAGATGGTGCGCTCTATTTCGTTGCCGCATCTGCAGAAGGTGCTGCAGTTGCTCGAACAGGCCTATCACAGCGGGCACCGCATCTTTATCATGGGTAATGGCGGTAGCGCGGCAACTGCCTCGCACTTTGCCCTTGATCTGGCTAAAAATACGATTGTCCCTGGCGCGCCTCGCCTGAAGGCTATTTCTTTGACTGATCACGTGCCGCTGATTACTGCCTGGAGCAATGATACTGCCTATGAGCATATTTTTGCCGAGCAGCTGGCCAACCTTATTGAGGCCGGGGATGTGGCTATCGGCATTAGCGCGAGTGGAAATTCGCGAAATGTGATTAATGCTCTCCACCTGGCCGGACGCTCGGGAGCTTTTACGATTGGCCTGTTGGGAGCGACCGGGGGCAAGATTAAGGATATGGTAGATGCTTATGTGCTGGCTCCAGGCCGCAATATTGAGCAGGAAGAGGACGCTCATATGATCCTGGCCCATATCATTACCAGGCATATGCGCCAGGTAGTGACGACGTATGCGCAAAAACTTGCCCTGGCTGGAACCAACGGCCAGGCTAACTAATTTGTTGGGATGCGCTTGCTCAGCGGAGCCGGAGAAAAAATCTCAAATGCTTCTCTGTGCTCCCTGGGCAGATATAGCTCGCGTGTTGAAGCTAGTTTAATATCAAATCCGCTTGAAAAGCTATCACAAGGGGATTTGGGATATCCTCAAGTAATCATTATTTAAACTGATTTGATATAACTCAGTCGTGCTAGATGTTAAAAAGCTTTGCCATACTCTCCAGAATGCGTGCCTCTGCGGCAAACTACCCTCTGCGTGGTTTGCCTCGTTACAACAGCCAAAATCTCAATTCCACGCTGAAGCTGCTTTGTTTGGGAAAATAGAGATAGGACCAGAAGCCTGGTCCATCTCTATTGGGTATGCTTGCTTTATTGGCGGAAGAAATCGACTGTGGCTTTGACGCCCTCTTCGAAAGATTTTGTGGGCTGCCAGCCTAGAAGGCGCGCGGCCTTGCTGGAGTCAAAATAGGCCATGTAGATATCGCCAGGGCGCTTGGGAGCTTTGATGATCTCTGGCGTATAGCCGGTCAGGGCCTGTAGGGTCTGGAAGATCTCGTTGACGGAGGTTGCCTTGCCGGTGCCAATGCAGAAGATCTCGTTGTCCCCTTTGCCGGCGGCCAGCAAATTAGCTCTGGCCACATCCTCGACGTATACATAGTCCTTGCTCTGGCCACCATCCCAGTCGATGCGTACCTTCTCATGGGCCAGGAAACGTTTGGCAAAGATGGCAATCACCCCAGCCTCTCCGTTGGGGTCCTGGCGAGGACCATAGACGTTTCCATAGCGCAGGGCGGTATAGGTGAGTCCATAAGCCTCCTGCCAGTAGCGCAGGTAGTGTTCGGCAACCATTTTTGTAATGCCGTAGGGTGATTCTGGCCGCTGCACAACCTCTTCGTTCAAGGGCAGGCTGGCAGGCGTACCGTATGTTGCGCCAGAAGAGGCGAAGATGATCTTGCGCGTACCTACGCGTACACAATTGCCAAGAACATTAAGTAAGCCCAGCACATTGACGCGCGCATCTAGCTGGGGATTCTTGGTAGAGACCGCTACGCTGTGCTGAGCCGCCTGGTGGCTAACGATCTCAGGCTGGATCTCGCTAAAGATCTGTGTCAGGCTTGCCTCATCTGTAATATCGGCGCGATAGAAACGTGCCTTTGGATTAAGATTAGTTTGTTTGCCGCCCCCTTCTTCCCAGAGATTATCTATAATGGCAACTTCGTGTCCGGCTGCTATATATTGATCAACAATGTGCGATCCAATAAAACCCGCACCACCTGTGACAAGTACTCGCAT

Protein sequences of DBSCAN-SWA_5

>CP035758|8739719:8747922|8746063_8746630_+|QBD83711.1|DBSCAN-SWA
MVRSISLPHLQKVLQLLEQAYHSGHRIFIMGNGGSAATASHFALDLAKNTIVPGAPRLKAISLTDHVPLITAWSNDTAYEHIFAEQLANLIEAGDVAIGISASGNSRNVINALHLAGRSGAFTIGLLGATGGKIKDMVDAYVLAPGRNIEQEEDAHMILAHIITRHMRQVVTTYAQKLALAGTNGQAN
>CP035758|8739719:8747922|8741413_8742814_+|QBD81452.1|DBSCAN-SWA
MGKQKRVLVIGLDCAPPELVFEQWRDELPNFRRVMDNGVWGKLESCIPAITVPAWSSMMSSKDPGTLGFYGFRNRGDHTYDKHVLANSNSVKTDRVWDVLSRAGKKVITVGVPQTYPPKPVNGIQVGCFLSPSTKNPERPYTYPPSAMKEIEAAVGEYLVDVPNFRTNDKDYLLRQIYTMTEKRFKLVKKWLVEKEWDFFMFVEMGTDRIHHGMWKYHDPTHHKYEVHPVYNNSIHDYYRYIDNEIGQILDLVDDDTTVFIVSDHGAKKMDGGLCVNEWLIKEGYLTLKSYPSKITALDKCEIDWSKTKVWGDGGYYARIFLNIEGREPQGIVKPEEVEALRNELKTKFEAIVDPDGVNIGTTVYKPQEVYKQCNGVPPDLIVYFGDLLWRSVGTVGYNSIYTFDNDTGPDDCNHAQFGIVIKHSADAHEGPGGRELQGLQLMDMAPTILKELDVPVPADMQGKIF
>CP035758|8739719:8747922|8739719_8740871_-|QBD81451.1|DBSCAN-SWA
MTSSKKVRVGIIGVGNCASSLVQGVHYYREANPDDFIPGLMHVNLGGYHIHDIEFSTAIDIDVNKVGKDLSEAIYAAPNNTYRFADVPKLGTKVQRGMTHDGLGKYLSQVISKAPGQTSDIVKILKDSGTDVVVNYLPVGSETATKWYVEQILQAGVGFVNCIPVFIAREKYWQDRFKDAGLPMIGDDIKSQVGATIVHRMLTRLFRERGVKVERTMQLNVGGNTDFYNMLERERLESKKISKTNAVTSQLDYEMGAENVHIGPSDYVAWLADRKWAYIRLEGRTFGDVPLNMELKLEVWDSPNSAGVVIDAVRMVKLALDRGISGTLEGPSAYLMKSPPVQYHDDVAHEMAEAFIREEHTPKAEKSPIPEQANGHKVETASE
>CP035758|8739719:8747922|8743019_8743616_+|QBD81453.1|DBSCAN-SWA
MANTGFTIWFTGLSGSGKSTLSDAIQERLAARGRNVEILDGDVVRTHLSKGLGFSREDRDTNIKRIAFVCSLLTRNGVACISAAIAPYREAREWARKEIGNFVEVYVKCPLEVCRQRDVKGLYKLVDEGKIKNFTGVDDPYEEPEHPELIVETNKESVEESVNRIIAKLEELGYLEPEEMNEDESKVVTDRLAALGYL
>CP035758|8739719:8747922|8743663_8744833_+|QBD81454.1|DBSCAN-SWA
MTDGLIAPHGGELIINMAAEAERAALEEKAKSLPTITVGSRQLADLEMLANGAYSPLGGFMGQADYLSVVKEMHLSNGLPWTVPITLPITPEQAEAIKTDSQVALVNAEGELQAVMTVTEKYGYDKHLEAREVYRTEEEAHPGVKNVYQQADVLLGGPVRVVRLQNQAFAKYRYTPTQSRALFAERGWKRVVGFQTRNPVHRAHEYIQKCALETVDGLYLHPLVGDTKGDDIPADVRMRCYEVLFENYYPANRVILGVLPAAMRYAGPREAVFHALMRKNYGCSHFIVGRDHAGVGNYYGTYDAQHIFTNFDPAKLGITPMAFEHAFFCRVCNSMASTKTCPHGNDQHVVLSGTKVRQMLRAGECPPPEFSRPEVAKVLVEAMRQPVSQ
>CP035758|8739719:8747922|8746998_8747922_-|QBD81456.1|DBSCAN-SWA
MRVLVTGGAGFIGSHIVDQYIAAGHEVAIIDNLWEEGGGKQTNLNPKARFYRADITDEASLTQIFSEIQPEIVSHQAAQHSVAVSTKNPQLDARVNVLGLLNVLGNCVRVGTRKIIFASSGATYGTPASLPLNEEVVQRPESPYGITKMVAEHYLRYWQEAYGLTYTALRYGNVYGPRQDPNGEAGVIAIFAKRFLAHEKVRIDWDGGQSKDYVYVEDVARANLLAAGKGDNEIFCIGTGKATSVNEIFQTLQALTGYTPEIIKAPKRPGDIYMAYFDSSKAARLLGWQPTKSFEEGVKATVDFFRQ
>CP035758|8739719:8747922|8744950_8746006_+|QBD81455.1|DBSCAN-SWA
MLIARAPMRISFGGGGTDLEAYYAKYGGMVISTAINKYFYAIVTTDESEDLQVISADFRSLFRHSPYNDLFWDGDLALPKAILHHFGVRRGINLFIASEVPPGTGLGSSSAAAVTLVRAISTLVEQPMTKQQVAELASYIEIEKMGMPIGKQDQYAAAFGSLNKITFTSEGVSVEPVKVAPEVRQTLESRLMLFFTGSSRESTSILKHQRKSTQNQDESVLRALHNIKRVAEEVQACLEKGDLDEFARLLHYSWQEKRRLAPNLSTGFIDECYELALRCGASAGKINGAGGGGFLMIYCHEHAQEDVTQALEERGLKRMNFHFDQQGATVILNTANFSNLWVEPYAAPTNS

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBD81451.1|8739719_8740871_-	inositol-3-phosphate synthase	A0A0H4IPK5	Stenotrophomonas_phage	8.8e-83	45.3
QBD81452.1|8741413_8742814_+	phosphodiesterase	NA	NA	NA	NA
QBD81453.1|8743019_8743616_+	adenylyl-sulfate kinase	A0A2K9L4R9	Tupanvirus	5.3e-31	46.5
QBD81454.1|8743663_8744833_+	sulfate adenylyltransferase	A0A2K9L0F0	Tupanvirus	2.1e-44	30.7
QBD81455.1|8744950_8746006_+	GHMP kinase	A0A222YW25	Synechococcus_phage	1.8e-42	33.2
QBD83711.1|8746063_8746630_+	SIS domain-containing protein	A0A067XQR2	Caulobacter_phage	1.0e-20	36.7
QBD81456.1|8746998_8747922_-	SDR family NAD(P)-dependent oxidoreductase	A0A2K9L0I7	Tupanvirus	5.8e-45	37.1