CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
CP032229	Streptomyces seoulensis strain KCTC 9819 chromosome, complete genome	3 crisprs	WYL,cas4,csa3,DEDDh,Cas9_archaeal,cas3,DinG	9	7	1	0
CP032230	Streptomyces seoulensis strain KCTC 9819 plasmid unnamed	0 crisprs	NA	0	0	1	0

1. CP032229

CRISPR-Cas detection and classification

Crispr_ID: CP032229_1

• CRISPR_ID: CP032229_1
• CRISPR_location: 14173-14738
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 10 spacers

Consensus repeat of CP032229_1

Consensus_repeat	Method
GGNNCGNCGGGNGGGNCG	CRT

spacers of CP032229_1

>1.1|14191|37|CP032229|CRT
GGATTGCAGATGGCGGGGTGGGGCTTGGAGCGCCTCC
>1.2|14246|46|CP032229|CRT
AGGCCCGCCGGGCGGGCGGGGCGAGGCCCGCCGGGCGGGCGGGGCG
>1.3|14310|37|CP032229|CRT
GGGGCAGGTGGCTCGGGTGGGACGAGGCCCGCGGGGC
>1.4|14365|28|CP032229|CRT
CGCGGAAGGAGGGCCGCCGGGCGGGACG
>1.5|14411|32|CP032229|CRT
GGGCCGGGGGCCCCGGTAGGACGAGGCTCGCC
>1.6|14461|33|CP032229|CRT
CGCGGGGCGAGGCCCGCCGGGTGGGGCGGGGCG
>1.7|14512|47|CP032229|CRT
GGGGCAGGTGGCCCGGGTGGGACGAGGCCCGCCGGGCGGGCGGGGCG
>1.8|14577|25|CP032229|CRT
GGGGCAGGTGGCCCCGGTAGGACGA
>1.9|14620|50|CP032229|CRT
GGCCGGGCGGGTGGCCGGGGCGGGACGGGCGGGTGGCCGGGGCGGGGCGA
>1.10|14688|33|CP032229|CRT
GGGCGCCTCCCCGGCCGGCGCGCCGGGGCCCGG

CRISPR arrays and Neighbor proteins around CP032229_1

CRISPR arrays

The CRISPR arrays of CP032229_1

>merge|CP032229|1|14173-14738|CRT
GGCCCGCCGGGCGGGGCGGGATTGCAGATGGCGGGGTGGGGCTTGGAGCGCCTCCCGCCGGGCGGGCGGGGCGAGGCCCGCCGGGCGGGCGGGGCGAGGCCCGCCGGGCGGGCGGGGCGGGATCGGCGGGTGGGGCGGGGGCAGGTGGCTCGGGTGGGACGAGGCCCGCGGGGCGGGTCGGCGGGTGGCCGGCGCGGAAGGAGGGCCGCCGGGCGGGACGGCGTCGGCGGGTGGCCGGGGGCCGGGGGCCCCGGTAGGACGAGGCTCGCCGGGCCGGCGGGTGGCCGGCGCGGGGCGAGGCCCGCCGGGTGGGGCGGGGCGGGGTCGACGGGTGGGGCGGGGGCAGGTGGCCCGGGTGGGACGAGGCCCGCCGGGCGGGCGGGGCGGGGTCGACGGGTGGGGCGGGGGCAGGTGGCCCCGGTAGGACGAGGCTCGCCGGGCGGGACGGGCCGGGCGGGTGGCCGGGGCGGGACGGGCGGGTGGCCGGGGCGGGGCGAGGCCCGCCGGGCGGGGCGGGGCGCCTCCCCGGCCGGCGCGCCGGGGCCCGGGGTCCAACTGCCGGGGCG

>CP032229|1|1|14173-14738|CRT
GGCCCGCCGGGCGGGGCG	GGATTGCAGATGGCGGGGTGGGGCTTGGAGCGCCTCC
CGCCGGGCGGGCGGGGCG	AGGCCCGCCGGGCGGGCGGGGCGAGGCCCGCCGGGCGGGCGGGGCG
GGATCGGCGGGTGGGGCG	GGGGCAGGTGGCTCGGGTGGGACGAGGCCCGCGGGGC
GGGTCGGCGGGTGGCCGG	CGCGGAAGGAGGGCCGCCGGGCGGGACG
GCGTCGGCGGGTGGCCGG	GGGCCGGGGGCCCCGGTAGGACGAGGCTCGCC
GGGCCGGCGGGTGGCCGG	CGCGGGGCGAGGCCCGCCGGGTGGGGCGGGGCG
GGGTCGACGGGTGGGGCG	GGGGCAGGTGGCCCGGGTGGGACGAGGCCCGCCGGGCGGGCGGGGCG
GGGTCGACGGGTGGGGCG	GGGGCAGGTGGCCCCGGTAGGACGA
GGCTCGCCGGGCGGGACG	GGCCGGGCGGGTGGCCGGGGCGGGACGGGCGGGTGGCCGGGGCGGGGCGA
GGCCCGCCGGGCGGGGCG	GGGCGCCTCCCCGGCCGGCGCGCCGGGGCCCGG
GGTCCAACTGCCGGGGCG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP032229.1|QBJ88879.1|20302_20515_-|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ88882.1|21624_22074_+|spore-associated-protein	unknown	unknown	gnl|CDD|225497
CP032229.1|QBJ88873.1|7787_9224_-|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|237865
CP032229.1|QBJ88884.1|23318_24734_-|alkaline-phosphatase-family-protein	unknown	unknown	gnl|CDD|366747
CP032229.1|QBJ88867.1|654_1218_-|nitroreductase	unknown	unknown	gnl|CDD|380312
CP032229.1|QBJ88869.1|2131_3133_+|LuxR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197715
CP032229.1|QBJ88872.1|7041_7635_-|TIGR00730-family-Rossman-fold-protein	unknown	unknown	gnl|CDD|129813
CP032229.1|QBJ88880.1|20701_20929_-|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ88885.1|24730_25900_-|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl|CDD|224007
CP032229.1|QBJ88868.1|1497_1809_-|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ88878.1|18367_18688_-|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ88870.1|3215_4520_-|Zn-dependent-hydrolase	unknown	unknown	gnl|CDD|236456
CP032229.1|QBJ88874.1|9264_11412_-|peptidase-M13	unknown	unknown	gnl|CDD|341056
CP032229.1|QBJ88875.1|11408_12869_-|MFS-transporter	unknown	unknown	gnl|CDD|340863
CP032229.1|QBJ88883.1|22168_23230_-|sugar-phosphate-isomerase/epimerase	unknown	unknown	gnl|CDD|224007
CP032229.1|QBJ88866.1|279_570_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|238045
CP032229.1|QBJ88877.1|15106_16360_-|hypothetical-protein	unknown	unknown	gnl|CDD|369647
CP032229.1|QBJ88871.1|4623_6561_-|S9-family-peptidase	unknown	unknown	gnl|CDD|224423
CP032229.1|QBJ88881.1|20971_21532_+|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ88886.1|25903_26779_-|hydrolase-TatD	unknown	unknown	gnl|CDD|224024

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP032229.1|QBJ88873.1|7787_9224_-|tetratricopeptide-repeat-protein	gnl|CDD|237865	PRK14951, PRK14951, DNA polymerase III subunits gamma and tau; Provisional.	7.23178e-07
CP032229.1|QBJ88884.1|23318_24734_-|alkaline-phosphatase-family-protein	gnl|CDD|366747	pfam01663, Phosphodiest, Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.	6.90129e-70
CP032229.1|QBJ88867.1|654_1218_-|nitroreductase	gnl|CDD|380312	cd02135, YdjA-like, nitroreductase family protein similar to Escherichia coli YdjA. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.	2.14857e-42
CP032229.1|QBJ88869.1|2131_3133_+|LuxR-family-transcriptional-regulator	gnl|CDD|197715	smart00421, HTH_LUXR, helix_turn_helix, Lux Regulon. lux regulon (activates the bioluminescence operon.	1.9853e-12
CP032229.1|QBJ88872.1|7041_7635_-|TIGR00730-family-Rossman-fold-protein	gnl|CDD|129813	TIGR00730, LOG_family_protein_YJL055W, TIGR00730 family protein. This model represents one branch of a subfamily of proteins of unknown function. Both PSI-BLAST and weak hits by this model show a low level of similarity to and suggest an evolutionary relationship of the subfamily to the DprA/Smf family of DNA-processing proteins involved in chromosomal transformation with foreign DNA. Both Aquifex aeolicus and Mycobacterium leprae have one member in each of two branches of this subfamily, suggesting that the branches may have distinct functions. [Hypothetical proteins, Conserved].	1.38566e-49
CP032229.1|QBJ88885.1|24730_25900_-|sugar-phosphate-isomerase/epimerase	gnl|CDD|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	5.22142e-10
CP032229.1|QBJ88870.1|3215_4520_-|Zn-dependent-hydrolase	gnl|CDD|236456	PRK09290, PRK09290, allantoate amidohydrolase; Reviewed.	9.2514e-144
CP032229.1|QBJ88874.1|9264_11412_-|peptidase-M13	gnl|CDD|341056	cd08662, M13, Peptidase family M13 includes neprilysin and endothelin-converting enzyme I. The M13 family of metallopeptidases includes neprilysin (neutral endopeptidase, NEP, enkephalinase, CD10, CALLA, EC 3.4.24.11), endothelin-converting enzyme I (ECE-1, EC 3.4.24.71), erythrocyte surface antigen KELL (ECE-3), phosphate-regulating gene on the X chromosome (PHEX), soluble secreted endopeptidase (SEP), and damage-induced neuronal endopeptidase (DINE)/X-converting enzyme (XCE). Proteins in this family fulfill a broad range of physiological roles due to the greater variation in the active site's S2' subsite allowing substrate specificity. NEP is expressed in a variety of tissues including kidney and brain, and is involved in many physiological and pathological processes, including blood pressure and inflammatory response. It degrades a wide array of substrates such as substance P, enkephalins, cholecystokinin, neurotensin and somatostatin. It is an important enzyme in the regulation of amyloid-beta (Abeta) protein that forms amyloid plaques that are associated with Alzeimers disease (AD). ECE-1 catalyzes the final rate-limiting step in the biosynthesis of endothelins via post-translational conversion of the biologically inactive big endothelins. Like NEP, it also hydrolyzes bradykinin, substance P, neurotensin, and Abeta. Endothelin-1 overproduction has been implicated in various diseases including stroke, asthma, hypertension, and cardiac and renal failure. Kell is a homolog of NEP and constitutes a major antigen on human erythrocytes; it preferentially cleaves big endothelin-3 to produce bioactive endothelin-3, but is also known to cleave substance P and neurokinin A. PHEX forms a complex interaction with fibroblast growth factor 23 (FGF23) and matrix extracellular phosphoglycoprotein, causing bone mineralization. A loss-of-function mutation in PHEX disrupts this interaction leading to hypophosphatemic rickets; X-linked hypophosphatemic (XLH) rickets is the most common form of metabolic rickets. ECEL1 is a brain metalloprotease which plays a critical role in the nervous regulation of the respiratory system, while DINE is abundantly expressed in the hypothalamus and its expression responds to nerve injury. A majority of these M13 proteases are prime therapeutic targets for selective inhibition.	1.39493e-178
CP032229.1|QBJ88875.1|11408_12869_-|MFS-transporter	gnl|CDD|340863	cd06173, MFS_MefA_like, Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	4.08306e-45
CP032229.1|QBJ88883.1|22168_23230_-|sugar-phosphate-isomerase/epimerase	gnl|CDD|224007	COG1082, IolE, Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism].	4.40323e-21
CP032229.1|QBJ88866.1|279_570_-|XRE-family-transcriptional-regulator	gnl|CDD|238045	cd00093, HTH_XRE, Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.	3.66566e-06
CP032229.1|QBJ88877.1|15106_16360_-|hypothetical-protein	gnl|CDD|369647	pfam08007, Cupin_4, Cupin superfamily protein. This family contains many hypothetical proteins that belong to the cupin superfamily.	1.05545e-29
CP032229.1|QBJ88871.1|4623_6561_-|S9-family-peptidase	gnl|CDD|224423	COG1506, DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism].	1.51054e-81
CP032229.1|QBJ88882.1|21624_22074_+|spore-associated-protein	gnl|CDD|225497	COG2946, COG2946, Putative phage replication protein RstA [DNA replication, recombination, and repair].	0.00261912
CP032229.1|QBJ88886.1|25903_26779_-|hydrolase-TatD	gnl|CDD|224024	COG1099, COG1099, Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only].	2.24829e-91

Protein sequences

>CP032229.1|QBJ88875.1|11408_12869_-|MFS-transporter
MTAITPPPPTATAAPAWRDVYVLAGMRGLSFAGDIAAATALTLLLQANGAGSYAVMALLLAAAVPPALLAPLTGRFADRFDSRRLIVTVASLQILACLAMTQTTTPALLIVLAVLLSTGLAFTHPVFAGLPAAMVGKDNIPRASAISQTTAMAGMVIAPGIAGFLTAHFGVRISLLLDAASFAVVVAGALTIRTRLHHTAPAAQSPADTGKQTGPAYRVSGDRFLRSILAVSGVVMAAASIINVLIVFYVRDTFGGSEETYGLIMSAWMAGLVPGALLVRRIKKLSHEALLIGSFLCISAGILATGLAPGAWWIVPCYIIGGFGNGAQATVTHIVINLRVPDSHRGRAFAALGAVSNTGPALGYLMGGVILGFIQPRYAFLLAGTCSLLAVLVFHRALLHTAATTPEPAPEPAPGPAAGPAAGPAADTVAGTAPESVTDTAAGTVRAESGLTVPEPAAGTVTGPALDTAREPAVPARPVPDKAASR
>CP032229.1|QBJ88874.1|9264_11412_-|peptidase-M13
MSADTAHDTSTGTGTGDTSTGTGTGDTSTGTGTGDAGTSTGFGAGDVDTDPSVRPQDDFHAHVNGRWLKAFRLPEHRAEATLLSLLAEKVQDDVVAVIRDSTPTPTPTPTATATATGTDAVPVAGAGRQIADLYASFMDEDALAVRGPADLTALLDAVRAVTAREELARLMGRLQREGVGGPVEATVDADTTGVRGYLLTLTQSGLALPGGPAAYLDPGHAPLREQYAAHVGAVLRLAGQADPQEAARTALRVESALAAAHTRPDASGRIRAQAEVTTAADLTATAAIAGGDGGGEGGFPWGAFLDGLGDIPSAARLQIRPGPYRGALDAWWSAHSVQELKLWLVWSQVHEAAPFAPPALFAENFRFYGQVLTGSRRARPRWMRATSFVQTVLGDEVGERYLRRHLAPGTLKAAADLVDALRAAYRGRLEQAGWMADSTRRAALAKLDALRVELGHPQDMAARGPLHTDPADLLGNVRRGRARSFERQLGRLAGPVDRGEWKVAPQAVTAYYRHGLNQVVVPAALLQPPLFDAGGDMTRNFALLGSVVCHEMSHAFDSRGSAYDGEGRLREWWSTEDRAEFTRRTALLISHYDRYVPGGLDGEHVSGARTAGENIADITGLTVAHTAFAAHLAASALTEAEQEAQTRRFFTLWATMWRVKRTPGRMRERLAHDRHAPPQVRCNAVLGHVPAFYRAFGVTETDSMFIPPEDRFTLL
>CP032229.1|QBJ88873.1|7787_9224_-|tetratricopeptide-repeat-protein
MAHTHPATPAPAAPGQSAPAPAAPAQGTSMVAAPVQAAQAPAVPAPALAAPVQAGSVMAAPAQPAPAPAASAPLRPCYAPGDGQVWHLLRLVPGPDIAVAAAASLLAVGAERAAVLLERLAGGGLCERTGPGRYRPRPAPPAHPAGVRPGDGEALRRLAGHYLHTAHHAERLLAPHRPQLPLAPVEPGCTPERFVSREAALAWLDEEHHALTAIRESARDRGERWTVFHLAACLNGHYVRRGHTALQQRQWADALRAAHALGDPEAQITAHRYAGQAASRAGRHPDALAHLQRAVRIAERHGRPGPQAWAYYILAWTEEMAGDDAAALTHAICAAGLFARAQQWRAQADALNAAGWYFTRLGDPVQAGRYCARALDLARRHRYLGGQAAALDSLGLLAQANGRHEDAVHAFTAALAHCRTLGNTYQEAGALDRLGDSYAATGRPADARTVWGSAAAVYRAQDRLDEAASVERRLTALA
>CP032229.1|QBJ88872.1|7041_7635_-|TIGR00730-family-Rossman-fold-protein
MEMPPEIAQSKKIAVFCGARDGARPGHLLLAREFGTALARRGLDLVYGAGGVGVMGAVAHSVIDAGGGVTGVVPRFLHERERADNAPGALFLVRSMHERKALMYRLSAGFAVLPGGFGTLDELLEVATWNQLSLMRKPIVVVNHQGFFDPLLGMLDHLVHEGFLKEAERSLIQEGRDVEDALDLLTAARTQPVPAAV
>CP032229.1|QBJ88871.1|4623_6561_-|S9-family-peptidase
MKFTDIDLLPVLGKPTLSGDGRFAAVAVTRPDLAADGYVSELWLAETDGSRPARLLTRGPHDAAPAFSPDGRHLAFLRPVPGGPGQIHLLPLDGGDARPVTSHPIGAGQPVWSPDSTRLAYMARVPAPGRYTGAPHTEAPRRITTLRYWADGFGFTVDRPRHLFVTDPFADDPAAATVQVTDGDFDHADVSWSPDGRLLAFTAARHQGAGDDLRNDLWVCAPDGTGLRALTGGGLILGCPRFAPDGATLCFAAEPLDENNNAYATMSYGLWSAPVDGSAPARRLTHEDYHLSFASQMIHPVADGVLFAADHRGEVHLLLVPYDGSTPTPLITGARQVNAYAAVDTPDGLTVAAVVSSATSAGDLLSLRAGEEHLLTGFGDRLTQQTDVLPVEEFTATTQDGYDLQGWIVRPRGEGPHPVLLQIKGGPYTQFGYTLNGPAALDEALVYASAGYAVVLGNPRGCSGYGQEHGMHVVDDLARKTAPDLLALLDTALEAPDLDGSRVGVMGGSFGGYMSAWMAAHHGARFRAFIGERGLYAVDSYAASSDDGVNVAIALYGADPARWAEKSPLTYADSITKPVLIIQSDEDRHCPMEQAQRLFVALKTRGVPVELLLFPGEGHDLSRSGLPSHRIARFEAVLEWWDRHL
>CP032229.1|QBJ88870.1|3215_4520_-|Zn-dependent-hydrolase
MSQPVAHRRTAQPAIDAERLLRRVEELGRIGRDPVTGGITREGFSRADREARTYVMRESRAAGLATSVDAAGNLMIRTRPPGTAPARPAVLMGSHLDTVVNGGRLDGAYGVLAALEVVQACAESGIETAYEPVAAAFSNEEGALFPQPFFGSSVLAGRLDGLPREPLDHDGHPLRGPLALAGGDLDALGSAVWPAEALAAYLELHVEQGPVLERARNRIGVVDGITGRTVLTLEISGSAGHCGTAPMPGRRDALAAAARATLAVERLATTLDLCRVATVGRLDIHPNSPNTIADTVRLTADLRDTDAARMHRAETVLTRELQDLAHQTGTRIETLARTHSAPVATSARLRALIEESCRETGAPYQSLPSGAGHDAQVVADLTPTAMIFVPSVGGVSHVPHEDTHPADLVLGAEILLRTALKTASGPCSTAPLRG
>CP032229.1|QBJ88869.1|2131_3133_+|LuxR-family-transcriptional-regulator
MLDLLGLDHQTESVYRAMLDHPEDGVEGLVARLGRPAKEIRDALDRLSELALVRFSTEDPTQLHAVSPHLGIEILLARQQAELAAQQQRVEASRAVAARLISEFAGQQEDVPEAGVQYLRGLESIRDYLTALNHQVRHEFLAFAPGGPQTEANMQASRPLNQRLLERGVQMRTIYLDSIRRDAATVAYAEWLVDKGGQVRTVPSLPNRMIICDRQVAIMAADSNATSVGAVVLSAPGLIAALCTLFDTTWQAAEALGTPPAGREQEGLTRQQAEVLHLLAEGHTDDAIARKLGVSPRTARRFANTLMAQLDARSRFQAGVRAVQYGHLPASVG
>CP032229.1|QBJ88868.1|1497_1809_-|hypothetical-protein
MYLVHVHVQPPVHGVLLPSGTADAVAACGRDVTGVEHVVVHADTHPHPVIGVYISAATLKAAEETAVTLWHHTLLHHHWLHPWTLLRAEVPLIPIDADRPGMS
>CP032229.1|QBJ88867.1|654_1218_-|nitroreductase
MDVMTAVLTRRSEHQLVEPAPSDAEFAYLLRAAATAPDHGRLRPWRWILVRGDARTALGRCFADDYDGPQPRRAHVQTKPQRAPLLATLVFTPQHATIPEWEQLAATSTMAGSLILLLHARGFGSVWRTGPFTQSQTTRHTLGLRPEERLLGWLYIGTPHHTRTPRRRTPDDITDHITVFTPELLTL
>CP032229.1|QBJ88866.1|279_570_-|XRE-family-transcriptional-regulator
MNMTLGERVRAATAALMHLTGENQADLATALGISQTQISRRQSGHAAWSLTDCEALATHYGIDVLDLLAGPTRACDTLAPHRRRTPAPAAAQGTPR
>CP032229.1|QBJ88877.1|15106_16360_-|hypothetical-protein
MYRLPPLRRIKAFRSTPSGIERNAMYDFTFEDLVGDEKVFFAEYFDKKPLLRKNAMPGDVRDILSVRKLDELLHMESIRPPYIKVNHNGSGVPEKGYTRSVVVQGVNITDTVVPEKIYELFRAGATVTWCSLNQIVPELRDFTRVISDKMAVRTDVVGFMTPTKKRGYLPHHDPVDLFIVQLEGTKRWKLWDLPAQREGDNASYTDEELGEPAIEVLLEPGDVLYLPYNTPHAAAAEDQVSLHLSIMMRPRMWKDLLRETFEQAASGPEFNQYPHIGALRDAGTEALFRQKIAALAARMDALDSGAELDRLAELGRTMPGSSHGTTFQTIAETDRITPSVLLRRTAAVVEFGANDGGRTQMTVNGHKIAVPTPVAETLAGLEADVPAGDIFPGVDPERATKAAQGLTRLGVLEVAPH
>CP032229.1|QBJ88878.1|18367_18688_-|hypothetical-protein
MRVRWWSGTVAGSWTVFRRTAGVRWPSLPRGMARCGRGWRRNCARGICRRRIWPSPPPSAPDPTGPDPTGPGLTGLLASPAPGLTGPGLTGPPGLTGPRAPCRLRS
>CP032229.1|QBJ88879.1|20302_20515_-|hypothetical-protein
MGRGCGDVGWLGCAGGCGGCGRGGGGWFGGGWGFGWCGFGFGWFFAGGGCGGGFCCGGFCGFCGCSGGFG
>CP032229.1|QBJ88880.1|20701_20929_-|hypothetical-protein
MSTVVWFGSLAAVSVPLTGAAGLFGLWVWLACAKLLQGVGESGLFVRRRAWVRVVVPLAVGGGDGSAVPGVGRGR
>CP032229.1|QBJ88881.1|20971_21532_+|hypothetical-protein
MYTRGRRLRFMVVSGMVVLALTGFSSSRGHGSRSHHSSGGGCSNSSQDHDSSSHSGSGGSYGSSTPDRDSDSYNSGGSTYRSRPTSRSSPTATARPLKDGTAVLKHCADTDDPYTTVEVRNPNTRDAYFTVKVSFKDASGFTMASTSDQVSVPAKGTATHRVFAARVGDVSRIEHCDVQRRADAYE
>CP032229.1|QBJ88882.1|21624_22074_+|spore-associated-protein
MRINRTTLTVGALAALALGAGTAMAAPASAAPNTTPQKVCGSSYRTVNSAAVGSLGTVYLTYNASNGKNCVTTIRNSPGTAVDMSAWLYVADTDQGDDDYGSFTSYAGPTYVYGKGHCVDWGGQIKNVYVQISGSNCASLKEKRVTYTR
>CP032229.1|QBJ88883.1|22168_23230_-|sugar-phosphate-isomerase/epimerase
MSRIANNDPELTHRLTRRGMLGVAAGATAAALLGAAAPASAATTVPTTGSAPAPAPAGGRGRPLLPPGRLGIQLYSLRDKVGTLGFAPVFAELEKYGYDEIEFAGYTQGSAGPITLPNLRRLARNHGLTPIGSHVGYYSDDPNAYTFAQNLEKVLDDAQALGLKHIGTASGPFRYGSTVDAWKRAAEEFNTYGAAARARGMKFYQHNHSDEFAFAADDPKVRLYDVLLAETDPDLVYLEMDIYWAYAGQFRFSKRPDGTTAPFEPLDYVLAHPHRYPLFHVKDGVSDPTNEYGYRMTDVGDGDIDYQRFISTVTHLRGQRSAHHWQTEHDTPPDSLSFARRSSAYLHSLREKC
>CP032229.1|QBJ88884.1|23318_24734_-|alkaline-phosphatase-family-protein
MTEHPAYPAQPTAGRPTPLLVLDVVGLTPRLLTHMPHVSALADQGSHAHLGTVLPAVTCAAQSTFLTGTTPAEHGIVGNGWYFRELGDILLWRQHNGLVAGDKIWDAARRAHPGYTVANICWWYAMGADTDFTVTPRPVYYADGRKEPDCYTRPPDLHDELSAEFGTFPLFQFWGPGAGLASSRWIIDATRHIQRTRHPDLTLCYLPHLDYDLQRYGPDDPRSLRAAADLDAAVAPLLADARAEGRTVVVLSEYGITRVDRPVDINRALRRAGLLEVHEQDGMEYLDPMASRAFAVADHQIAHVYVRRPEDLDATRAALTGLPGIAQLLDDEGKKDHHLDHPRSGELVALAEPDAWFTYYYWLDDARAPDFARLVEIHRKPGYDPVELFMDPLDPYVKVKAATALARKKLGLRYRMAVVPLDPSPIRGSHGRLPASDDDGPLLICSTPRAVGDRLAATDVKSLLLRLAGLT
>CP032229.1|QBJ88885.1|24730_25900_-|sugar-phosphate-isomerase/epimerase
MRFRHPDGTLVHLAYCTNVHPAETLDAVVAQLRDHCEPIRRRLGRDRLGIGLWLAKDAARTLENDPCALAALRAELDRRGLEVVTLNGFPYEGFGSQQVKYRVYTPDWADPERLRHTTALARILAGLLPDDIADGSISTLPLAWRTVATPARMETARTALRTLGDRLDALAELTGRSVRIGLEPEPGCVIETTADALTPLTDIAHPRIGICVDTCHLATSFEDPDTALDALARADVPIVKSQLSAALHAEHPHRPDVREALTAFDEPRFLHQTRTLTPTGRQGTDDLGEALQNGALPDSAPWRTHVHVPLHAAPAAPLTSTLPVLATALTRLVGGPHPLTRHLEVETYTWHALPAALRPRTRAQLTDGIAAELSLARDLLTDLGLKELP
>CP032229.1|QBJ88886.1|25903_26779_-|hydrolase-TatD
MRLFDPHIHMTSRTTDDYEAMRTAGVRAVVEPAFWLGQPRTSTASFLDYFDSLLGWEPFRAAQYGIAHHCTIALNPKEANDPRCTPVLDELPRYLVKDRVVAVGEIGYDSMTPAEDTALAAQLQLAADHGLPALVHTPHRDKAAGLRRTLDAVRESALAPDRVLLDHLNETTVKEAKDSGCWLGFSVYPDTKMDEERMVAVLRAHGPEQVLINSAADWGRSDPLKTRKVADLMLAEGFTEDDVDRVLWRNPVAFYGLSGRLDLDVTATDATHEGNTILRGAPRETAPAGQE

Crispr_ID: CP032229_2

• CRISPR_ID: CP032229_2
• CRISPR_location: 317309-317507
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 3 spacers

Consensus repeat of CP032229_2

Consensus_repeat	Method
CCCCGTGCGCGGGGAGCAG	PILER-CR

spacers of CP032229_2

>2.1|317328|42|CP032229|PILER-CR
TGGCGGGCCGAGCTCTGGGCGCGAGCCCCGTCGGGAAGAGCT
>2.2|317389|39|CP032229|PILER-CR
CGCGAGAGCCAGCACGCCGCGCCAGCTGGTCGGGCGTCC
>2.3|317447|42|CP032229|PILER-CR
TACACCCGGCTGCTGGAGGCGTACGGACGGCTGGGACCATCC

CRISPR arrays and Neighbor proteins around CP032229_2

CRISPR arrays

The CRISPR arrays of CP032229_2

>merge|CP032229|2|317309-317507|PILER-CR
CCCCGTGCGCGGGGAGCAGTGGCGGGCCGAGCTCTGGGCGCGAGCCCCGTCGGGAAGAGCTCCCCGCGCGCGGGGAGCAGCGCGAGAGCCAGCACGCCGCGCCAGCTGGTCGGGCGTCCCTGCGTGCGCGGGGAGCAGTACACCCGGCTGCTGGAGGCGTACGGACGGCTGGGACCATCCCCGCGTGCGCGGGGAGCAG

>CP032229|2|1|317309-317507|PILER-CR
CCCCGTGCGCGGGGAGCAG	TGGCGGGCCGAGCTCTGGGCGCGAGCCCCGTCGGGAAGAGCT
CCCCGCGCGCGGGGAGCAG	CGCGAGAGCCAGCACGCCGCGCCAGCTGGTCGGGCGTCC
CTGCGTGCGCGGGGAGCAG	TACACCCGGCTGCTGGAGGCGTACGGACGGCTGGGACCATCC
CCGCGTGCGCGGGGAGCAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP032229.1|QBJ89117.1|322898_323453_-|PadR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|378427
CP032229.1|QBJ89115.1|321252_322191_+|fibronectin-type-III-domain-containing-protein	unknown	unknown	gnl|CDD|238020
CP032229.1|QBJ89107.1|311018_311468_+|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ93938.1|310267_310765_+|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ89109.1|313683_314982_+|sensor-histidine-kinase	unknown	unknown	gnl|CDD|226951
CP032229.1|QBJ89119.1|325732_326107_-|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ89118.1|323492_325508_-|NADPH-dependent-2,4-dienoyl-CoA-reductase	unknown	unknown	gnl|CDD|239240
CP032229.1|QBJ89110.1|316563_317049_-|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ89111.1|318057_319050_+|dihydroxyacetone-kinase-subunit-DhaK	unknown	unknown	gnl|CDD|237724
CP032229.1|QBJ89104.1|302340_302712_+|BlaI/MecI/CopY-family-transcriptional-regulator	unknown	unknown	gnl|CDD|367747
CP032229.1|QBJ89106.1|306176_308864_-|hypothetical-protein	unknown	unknown	gnl|CDD|238871
CP032229.1|QBJ89112.1|319096_319708_+|dihydroxyacetone-kinase-subunit-L	unknown	unknown	gnl|CDD|274099
CP032229.1|QBJ89114.1|320154_320886_-|hypothetical-protein	unknown	unknown	gnl|CDD|369321
CP032229.1|QBJ89103.1|301777_302188_-|hypothetical-protein	unknown	unknown	gnl|CDD|182775
CP032229.1|QBJ89108.1|311692_311878_+|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ89113.1|319700_320111_+|PTS-fructose-transporter-subunit-IIA	unknown	unknown	gnl|CDD|131417
CP032229.1|QBJ89105.1|302708_303650_+|M56-family-peptidase	unknown	unknown	gnl|CDD|320685
CP032229.1|QBJ89116.1|322342_322894_+|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ89120.1|326191_327073_-|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ93939.1|315170_315989_+|hypothetical-protein	unknown	unknown	gnl|CDD|227049

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP032229.1|QBJ89117.1|322898_323453_-|PadR-family-transcriptional-regulator	gnl|CDD|378427	pfam10400, Vir_act_alpha_C, Virulence activator alpha C-term. This structure is homo-dimeric, and the domain here is the C-terminal half of the structure, often associated with PadR upstream, (pfam03551), which is a transcriptional regulator.	2.43229e-20
CP032229.1|QBJ89115.1|321252_322191_+|fibronectin-type-III-domain-containing-protein	gnl|CDD|238020	cd00063, FN3, Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.	1.33013e-12
CP032229.1|QBJ93939.1|315170_315989_+|hypothetical-protein	gnl|CDD|227049	COG4705, COG4705, Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown].	6.04199e-64
CP032229.1|QBJ89109.1|313683_314982_+|sensor-histidine-kinase	gnl|CDD|226951	COG4585, COG4585, Signal transduction histidine kinase [Signal transduction mechanisms].	2.75933e-26
CP032229.1|QBJ89118.1|323492_325508_-|NADPH-dependent-2,4-dienoyl-CoA-reductase	gnl|CDD|239240	cd02930, DCR_FMN, 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the flavin and iron-sulfur cofactors. Metabolism of unsaturated fatty acids requires auxiliary enzymes in addition to those used in b-oxidation. After a given number of cycles through the b-oxidation pathway, those unsaturated fatty acyl-CoAs with double bonds at even-numbered carbon positions contain 2-trans, 4-cis double bonds that can not be modified by enoyl-CoA hydratase. DCR utilizes NADPH to remove the C4-C5 double bond. DCR can catalyze the reduction of both natural fatty acids with cis double bonds, as well as substrates containing trans double bonds. The reaction is initiated by hybrid transfer from NADPH to FAD, which in turn transfers electrons, one at a time, to FMN via the 4Fe-4S cluster. The fully reduced FMN provides a hydrid ion to the C5 atom of substrate, and Tyr and His are proposed to form a catalytic dyad that protonates the C4 atom of the substrate and completes the reaction.	0
CP032229.1|QBJ89111.1|318057_319050_+|dihydroxyacetone-kinase-subunit-DhaK	gnl|CDD|237724	PRK14481, PRK14481, dihydroxyacetone kinase subunit DhaK; Provisional.	0
CP032229.1|QBJ89104.1|302340_302712_+|BlaI/MecI/CopY-family-transcriptional-regulator	gnl|CDD|367747	pfam03965, Penicillinase_R, Penicillinase repressor. The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.	1.37208e-17
CP032229.1|QBJ89106.1|306176_308864_-|hypothetical-protein	gnl|CDD|238871	cd01833, XynB_like, SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	1.92611e-32
CP032229.1|QBJ89112.1|319096_319708_+|dihydroxyacetone-kinase-subunit-L	gnl|CDD|274099	TIGR02365, dha_L_ycgS, dihydroxyacetone kinase, phosphoprotein-dependent, L subunit. Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.	1.19111e-80
CP032229.1|QBJ89114.1|320154_320886_-|hypothetical-protein	gnl|CDD|369321	pfam07335, Glyco_hydro_75, Fungal chitosanase of glycosyl hydrolase group 75. This family consists of several fungal chitosanase proteins. Chitin, xylan, 6-O-sulphated chitosan and O-carboxymethyl chitin are indigestible by chitosanase. EC:3.2.1.132. The mechanism is likely to be inverting, and the probable catalytic neutrophile base is Asp, with the probable catalytic proton donor being Glu. (see the Chitosanase web-page from CAZY).	1.30091e-25
CP032229.1|QBJ89103.1|301777_302188_-|hypothetical-protein	gnl|CDD|182775	PRK10847, PRK10847, DedA family protein.	0.00916856
CP032229.1|QBJ89113.1|319700_320111_+|PTS-fructose-transporter-subunit-IIA	gnl|CDD|131417	TIGR02364, dha_pts, dihydroxyacetone kinase, phosphotransfer subunit. In E. coli and many other bacteria, unlike the yeasts and a few bacteria such as Citrobacter freundii, the dihydroxyacetone kinase (also called glycerone kinase) transfers a phosphate from a phosphoprotein rather than from ATP and contains multiple subunits. This protein, which resembles proteins of PTS transport systems, is found with its gene adjacent to.	1.13231e-23
CP032229.1|QBJ89105.1|302708_303650_+|M56-family-peptidase	gnl|CDD|320685	cd07326, M56_BlaR1_MecR1_like, Peptidase M56-like including those in BlaR1 and MecR1, integral membrane metallopeptidase. This family contains peptidase M56, which includes zinc metalloprotease domain in MecR1 as well as BlaR1. MecR1 is a transmembrane beta-lactam sensor/signal transducer protein that regulates the expression of an altered penicillin-binding protein PBP2a, which resists inactivation by beta-lactam antibiotics, in methicillin-resistant Staphylococcus aureus (MRSA). BlaR1 regulates the inducible expression of a class A beta-lactamase that hydrolytically destroys certain ?-lactam antibiotics in MRSA. Both, MecR1 and BlaR1, are transmembrane proteins that consist of four transmembrane helices, a cytoplasmic zinc protease domain, and the soluble C-terminal extracellular sensor domain, and are highly similar in sequence and function. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. All members contain the zinc metalloprotease motif (HEXXH). Homologs of this peptidase domain are also found in a number of other bacterial genome sequences, most of which are as yet uncharacterized.	8.17736e-23

Protein sequences

>CP032229.1|QBJ89110.1|316563_317049_-|hypothetical-protein
MMHRDIPSHEHLLAPAAILEFSDDLRVADVRPLRNFLAARLSELARDQEEGTDARWAAEHLARTIDAACRDLADALVSWEIELTEGDINRPGHVQRLRQNLATGWDRLVQTAQRYAGHPDYLPRWRPLRYCCVEHAEFVEQALGDATDSGILYSGSPRHDE
>CP032229.1|QBJ93939.1|315170_315989_+|hypothetical-protein
MSTEQVLGQRPPATARVRIAEGANKVPEVTVYFWIIKVLTTGMGETASDFLARLLGPIPAVALGGIAFVASLVLQFAVRRYVAWVYWTAIVMVSVFGTMTADVLHVALGVSYTLSTPLFVIALAAVFAIWYASERTLSIHSIRTRRREVFYWAAVLATFALGTAAGDLTASTGLAYLGSIALFAVTIGIPALAFRMGALGAVAAFWTAYVLTRPLGASLADWMALAQIRGGLGWGLGPVTLSWTAAILGFVAFLTVTRKDVAETNRHARHAS
>CP032229.1|QBJ89109.1|313683_314982_+|sensor-histidine-kinase
MTLVTRTAHPVTVAGGESGGTGSLTALSSRLGERLRRADRAHPWVLNAAVVALVVSVFCVPDLLHGIDDGDEAGRFRLTPARLPVIEILALQAGLVLPLLWRRRRPALAFGVIAAVFFLQWFLGTALRADIALFVALYGVALRARTPQLLWSCGITASALVPAAVRVSGVLSVWVSLFFLLSTATAAVALGLTVRIRRAQLAGLRDRATRLETERDQRSRLAAAAERARVARGMHDVVGHNLAVVVTLADAGLRVNASGQRPGPEVLRSISDAGRQALGELRRVLGVLGEHAQDEGPGLMPQPRLADIGALCEGVRAVGLNVVHRTVGNVDDLDGKVQLTAYRIAQEALINSLKHAGPGARVKLVVVVSGPRLVITVRDGGPADGDSESRGRARQEGYGLAGMREHAARCGGRLHAGPAGRGWAVEAVLQTP
>CP032229.1|QBJ89108.1|311692_311878_+|hypothetical-protein
MGYGVVVEELAVEVMAQLPDDRARREVMALVEVARMDPHAWPDVRDPGSVEEIRETFGRRC
>CP032229.1|QBJ89107.1|311018_311468_+|hypothetical-protein
MGMDLNDVIDRAELHQEVARRFGNQPAPSLRPQVDAYLAGAWSLFETAMKTYDPANAQGLVLAAAEAHRRYTAPGALRTAGFLAFTFRELATNKRWDADLDLTPQAAWAARVVECVRAGLGDERFSHLIEGIGDILAELATEAEPVSVR
>CP032229.1|QBJ93938.1|310267_310765_+|hypothetical-protein
MPSAPIGGGAAADRIADALGTPNVIGEKANVTAFVVRRFVDRGLLVDLSANPDGTLHHPSQVAEVCRREDLADLVAADTPLGPEQAAARLQVRRADFDHMVRLGWLQSPQSIEVRFGTSRAGAVDVALYTTASVDAVIPAHPEVDWGQLRAVVKGRRSPLAALAK
>CP032229.1|QBJ89106.1|306176_308864_-|hypothetical-protein
MVVTGSALSAGPAAAATAREQDSGAACAAHATSFEVTAGAPAMSIRMGCAGDAGSLRTLAHSDSDLVVAFDYNVPERRDETRALAQDAVAAVQTDQTSGHTLAQALYDHARDNAVGLYPATDAGDYDGRITATGDSIVLVLPTAEVGTSATWWQKFIANGVGWAVSIGASAICLALTAPGAPLAAPVCLGVGGATGAFVTEAMNAAFDHASFGDPDTWGALLGAAFWGAVSGAASGYLVKWASDAAGTFVTGLQLSLRGFAAKIGNLGNPLTYISDRLNDMVPALLRRLNDLQRGVGGTDAPLRVMVVGDSMTQGYEGDWTWRYRLWKWFHDQRIDVDFVGPYKGTKAQAQPQPPARPALQDEVPGASLDNPDTSGGYAAGVDPAFDSDHFGVWGRQAMQDKKLIRGIVAQYKPDMILVGLGFNDMGWFVSGAQGTLDSMKTFVDEARVARPDVKFAVADVPQRTYIGGRDDLPLSTTQYDLMLRDAIPLWSTPVSPVQLVDWSGNYTCARDACPAGYDGLHPNALGEFQIAHAFETTLHDRYGIGQIVPDVPPSVPDRPSGIAANVRAVSSDLGVTVTWDRVYGARGYTVRSRLVGATAWTETPVQANRYDTTWTQDGWEWEYSVRVDDAGDGTSAWSPLVRATAHPHTAAPPTEILTHPTMDGVDVTWEPAAGPYSDSVDRYEIITLDKDTPGAVLQSTAVRGTSAHIGGLTTGHHYVVAVATWNTVGGGMPAIARPVTIGARTPPVPTDLRIKSVDATTVQLDWSGSPQAAGYRVWYHKRTTSNPWLSDETISDTPGRGIAFLFPGNWNFEFAVTAVNGQMESPRSDTVFVPEPPGTGGGSTGAPGTGTSDAFRKAARTGDASAPDVGQDLARLRNAPTTSPSSVPTAHPHT
>CP032229.1|QBJ89105.1|302708_303650_+|M56-family-peptidase
MITLLLVPLFLPWALPPLARRTVERVRPEIALWTVTCATVTLAIGVVASLGLLLLPLSLKLPPAAALAELVRPLAAGPRLLVLGVSALAGGSLALAGYQALRQAALEMAHLRAARRRVAGVPDAGGLCVLSDPRPDAFALPGGLRRADRIVVTTGMLRALDPVQREALLAHERAHLAAKHHLFLSAAQIAGWCHPALAAVTAHISFAAERAADEAAASRCGDRNVTAHAVGRAALAASRSRSATGAPALAPGATTGPVPARVKALLAPAPVRRMVPALLAMALVCSAAGASSTAGAVWLHHGVEIAQGERSSD
>CP032229.1|QBJ89104.1|302340_302712_+|BlaI/MecI/CopY-family-transcriptional-regulator
MTDAASERRPAGELEASVLTALCAATEPRTAAEVRAAIPQELARTTVATLLARLHDKGAVGRTPGRRGFLYFAVEDSHSLTAQRMHRELNQDDDRSTVLARFVKGLSPSDEAELKRLLEGGSR
>CP032229.1|QBJ89103.1|301777_302188_-|hypothetical-protein
MTLVHQAVPSLQLAVNLVDAQSLLAAFGTLGIAVAMFAEAGLLIGFFLPGDSPLFIAGLLRASGSTGASGRLSLGWVLVATATVGLVMAGYGLGASVPNVDRYFLPIIAVIVVVSLIPVGLELVRSRRSYAANGAA
>CP032229.1|QBJ89111.1|318057_319050_+|dihydroxyacetone-kinase-subunit-DhaK
MKMLINVPETVVADALRGMAAAYPDLNVDVENRVIVRRDAPVAGQVGLVSGGGSGHEPLHGGFVGPGMLAAACPGEVFTSPVPDQMARAAAAVDSGAGVLFIVKNYTGDVLNFDMAAELAEDEGIQVGKVLVNDDVAVTDSLFTAGRRGTGATLFVEKIAGAAAAEGQPLERVEAIGRQVNDSSRSFGVALSAVTTPAKGSPTFDLPPGELELGIGIHGEPGRERRPMMTSGEIADFAVNAILDDMTPRGPVLVLVNGMGATPLLELFGFNAEVQRVLAERGVAVARTLVGNYVTSLDMAGASVTLCQVDEELLRLWDAPVRTPALRWGM
>CP032229.1|QBJ89112.1|319096_319708_+|dihydroxyacetone-kinase-subunit-L
MLDADFFRRWITATAASVDREAQRLTALDSAIGDADHGSNLQRGFAAVLATLEKEAPQSPGAVLSLAGRQLISTVGGASGPLYGTLLRRAGKVLGDAPEVSEAQLAEALRAGVDGVMALGGAAPGDKTMLDALIPAVDALGEGFDAARRAAESGAVETTPMQARKGRASYLGERSIGHQDPGATSSSLLIAALVTAAEGGSDE
>CP032229.1|QBJ89113.1|319700_320111_+|PTS-fructose-transporter-subunit-IIA
MSDERYVGIVLVSHSAEVAESVAGLAKALAGGATTVPVAAAGGTEGGDFGTSAELISAAAAAVDQGAGVAVLTDLGSAVLTVKALLAEGDELPADTRLVDAPFVEGAVAAVVTAATGADLDAVVAAAGEAYAYRKA
>CP032229.1|QBJ89114.1|320154_320886_-|hypothetical-protein
MRDGVRNVPYGRFLSVRFPSLVPVLAGAALLAPTSPPAAATTHGVPPGAPVAAAELRARTRDCAQVSHGRYREDANGPAKVRVCGTRDAVFWKADLDIDCDGRPGTRCNRRTDPYFSPATAFPQSDGRPLDAERLPYIVIPPASALWDHRAHGVRGGSVAAVLYRDRVRYAVVGDTGPRDIIGEASYATARALGIDPDPRAGGVPSGVTYIVFRDTRTRPIEDHDETVAQGEQLARQFVGRTG
>CP032229.1|QBJ89115.1|321252_322191_+|fibronectin-type-III-domain-containing-protein
MPLCAALLLASCGTAGGASDEGPAPGAPARVTAEAGSATSVHVMWNAAGSGVHAYEVYRGPTKVTEVPAAQHMVDVPRLRPSTMYAFTVRARSAGGRLGPPSREVRARTPAYVAADHVAPSRPGRVTGKVVDGRAVQLSWAAAHDDRGVRSYAIQQGGVGIHVVGGAQTATVVTGLRPGTRYAFTVRAQDAAGNLSPASTPVRLTTPGAGDHRGTMPTGFDVVSRRTAGSYYLDLSWDPPDVDGVITEYQIRLDGDTDSSLVWGGTPPTGRARHSLYAGQKAGETHRVRLRARLPDGTWGGFSAERTVTTGR
>CP032229.1|QBJ89116.1|322342_322894_+|hypothetical-protein
MRRIRILPRYAAPLAAVLLPPALAGPSAAVSGISVSTSGTDVSVVTSACALNSGSWGTASLLGAQQTSFAQGRQVALSGTTVSQSAAWSGVTPGTYTVTVRCSNGVSAGSQVVIVPAAATPTPAPTRAATATAAPTRGVAGGLGGATRDYGTLTLGVGAALVGSAVIAGAWFLRRRPRSYRRY
>CP032229.1|QBJ89117.1|322898_323453_-|PadR-family-transcriptional-regulator
MSLPHAILTALLEKPSSGLELTRRFDKSIAYFWPSTHQQIYRELGKLEAEGFIRALPSAQPARGQKKSYEVLPAGRAELARWTAASQDPKPLRDAMLLRMRAAAVVGTAGLAADMRRHLELHENQLAVYREIEKRDFPPGRDTPQDRLRHLVLRAGIDLETFWAQWLAEALKELPDFEPDGPEG
>CP032229.1|QBJ89118.1|323492_325508_-|NADPH-dependent-2,4-dienoyl-CoA-reductase
MSRYPHLLSPLDLGFTTLPNRVLMGSMHVGLEEAEHGFERMAAFYAARARGGVGLIVTGGIAPNEEGRPWSGGAKLTTEAEAEEHRVVTDAVHQEGGRIALQILHFGRYAYHADLVAPSPLQAPISPHVPRELTDADVERTIEDYARTARLAQQAGYDGVEIMGSEGYLVNEFIAAGTNHRTDRWGGSYENRMRFPVEIVRRVREAVGEDFIIIYRLSMLDLVPGGSTLPEVVTLAKAVEAAGATLINTGIGWHEARIPTIATSVPRGAYTWVTKKLMGEVSVPLVTTNRINTPEIAEELLADGRADMVSVARPMLADPDFVAKAAEGRPEAINTCIGCNQACLDHTFSGKITSCLVNPRACHETELVLTPTRLKKRVAVVGAGPAGLACAVSAAERGHHVTLFDAASEIGGQLNVARKVPGKQEFDETLRYFRHQLDTHGVDVRLGTWITPGDLDAYDEVVVATGVTPRTPDIPGIDHPRVVGYLDVLRDNAPVGDRVAVLGAGGIGFDVAEFLTDAGDKAHEDPETYFRAWGVDMDYAAPGGLTAPSRPASPRTVHLLQRKATKVGAGLGKTTGWIHRTELKHRGVTMVPGVRYDRIDDAGLHITVGEESHVLEVDTVVLCTGQEPRRDLYEQLIAAGVSAHLIGGADVAAELDAKRAIKQGTELAAAL
>CP032229.1|QBJ89119.1|325732_326107_-|hypothetical-protein
MTNTEASHQETVSVEISGCSPDDARVVFDVLSACFASDRDAGETPQQQDEARPMVWLSTYDIADSRTGNCPPAKLSASVQADVQGGYWAVNRFREALDEMFTVEETATASGDQERELHLLLGSR
>CP032229.1|QBJ89120.1|326191_327073_-|hypothetical-protein
MPAPARKRRHALSAGLVTLATAAAVSLGAAAPASAADTWTETGSDRADPLTESQGLTSVEVPANSPNRYTGIGTIPVGVSSRGWNHVGDPDAPYNGYYIEPYQRDSGNSKMYRVQAPGGAWSEYTHTLAPGEAMNNSWSAISPDGQWMLSGEWGTMNRLLVFPTPGINPATSPSADLKLASNVTLDHPVRDVQGCDFSGPTTLLCSSDDPEGTLFGMTKPLLQIDLSAAPNGTSDVSGHVTALRQLPLRSSCSGSFEAEGIDYDRRTGILRVIVVSPGFCVITDSKTYKFTRG

Crispr_ID: CP032229_3

• CRISPR_ID: CP032229_3
• CRISPR_location: 3350709-3350981
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 6 spacers

Consensus repeat of CP032229_3

Consensus_repeat	Method
GTCNTCGGCGGGTGCGGGTGG	CRT

spacers of CP032229_3

>3.1|3350730|18|CP032229|CRT
CCCCGGAGGGGCGGAATC
>3.2|3350769|30|CP032229|CRT
GGGTGCGGGTGGGAACGGTGGGGCGGGGGC
>3.3|3350820|18|CP032229|CRT
ACTCGGTGGGGCGGGGGC
>3.4|3350859|18|CP032229|CRT
GCTCGGTGGGGTGGGGGC
>3.5|3350898|18|CP032229|CRT
GCCCGGTGGGACGGGGGC
>3.6|3350937|24|CP032229|CRT
GTGTTTGTCTTTGGGGGAGCATGG

CRISPR arrays and Neighbor proteins around CP032229_3

CRISPR arrays

The CRISPR arrays of CP032229_3

>merge|CP032229|3|3350709-3350981|CRT
TTCGTCGTCGGGTGCGGGTGGCCCCGGAGGGGCGGAATCGCCGTCGGCGGGTGCGGGTGCGGGTGCGGGTGGGAACGGTGGGGCGGGGGCGTCGCCGGCGGGTGCGGGTGGACTCGGTGGGGCGGGGGCGTCGTCGGCGGGTGCGGGTGGGCTCGGTGGGGTGGGGGCGTCTTCGGCCGGTGCGGGTGGGCCCGGTGGGACGGGGGCGTCTTCGGGGGGTGGGGGTGGGTGTTTGTCTTTGGGGGAGCATGGGGCTGTGGGGGATGGGTGGGG

>CP032229|3|2|3350709-3350981|CRT
TTCGTCGTCGGGTGCGGGTGG	CCCCGGAGGGGCGGAATC
GCCGTCGGCGGGTGCGGGTGC	GGGTGCGGGTGGGAACGGTGGGGCGGGGGC
GTCGCCGGCGGGTGCGGGTGG	ACTCGGTGGGGCGGGGGC
GTCGTCGGCGGGTGCGGGTGG	GCTCGGTGGGGTGGGGGC
GTCTTCGGCCGGTGCGGGTGG	GCCCGGTGGGACGGGGGC
GTCTTCGGGGGGTGGGGGTGG	GTGTTTGTCTTTGGGGGAGCATGG
GGCTGTGGGGGATGGGTGGGG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
CP032229.1|QBJ91567.1|3345919_3346612_-|GntR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|224715
CP032229.1|QBJ91572.1|3352695_3353037_+|YbaB/EbfC-family-nucleoid-associated-protein	unknown	unknown	gnl|CDD|234669
CP032229.1|QBJ91580.1|3360537_3361596_+|aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl|CDD|237845
CP032229.1|QBJ94183.1|3340605_3341487_-|XRE-family-transcriptional-regulator	unknown	unknown	gnl|CDD|376540
CP032229.1|QBJ91566.1|3344852_3345923_+|DUF4157-domain-containing-protein	unknown	unknown	gnl|CDD|379338
CP032229.1|QBJ91578.1|3358527_3359106_+|Uma2-family-endonuclease	unknown	unknown	gnl|CDD|368559
CP032229.1|QBJ91564.1|3342887_3343658_+|SDR-family-oxidoreductase	unknown	unknown	gnl|CDD|180604
CP032229.1|QBJ91575.1|3354421_3356701_+|tetratricopeptide-repeat-protein	unknown	unknown	gnl|CDD|315987
CP032229.1|QBJ91579.1|3359260_3360538_+|aspartate-kinase	unknown	unknown	gnl|CDD|235843
CP032229.1|QBJ91565.1|3343661_3344537_-|LysR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|223656
CP032229.1|QBJ91562.1|3341611_3342043_+|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ91573.1|3353089_3353689_+|recombination-protein-RecR	unknown	unknown	gnl|CDD|234616
CP032229.1|QBJ91576.1|3356756_3357182_+|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ91570.1|3348990_3350376_-|aspartate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|235687
CP032229.1|QBJ91563.1|3342035_3342686_-|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ91568.1|3346766_3347387_-|TetR/AcrR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|367243
CP032229.1|QBJ91569.1|3347378_3349007_+|FAD-dependent-oxidoreductase	unknown	unknown	gnl|CDD|236199
CP032229.1|QBJ91577.1|3357505_3358477_+|hypothetical-protein	unknown	unknown	unknown
CP032229.1|QBJ91574.1|3353681_3354341_+|DUF5063-domain-containing-protein	unknown	unknown	gnl|CDD|374737
CP032229.1|QBJ94184.1|3351502_3352393_-|SLATT-domain-containing-protein	unknown	unknown	gnl|CDD|375613

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
CP032229.1|QBJ91567.1|3345919_3346612_-|GntR-family-transcriptional-regulator	gnl|CDD|224715	COG1802, GntR, Transcriptional regulators [Transcription].	1.42652e-25
CP032229.1|QBJ91572.1|3352695_3353037_+|YbaB/EbfC-family-nucleoid-associated-protein	gnl|CDD|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	3.34926e-39
CP032229.1|QBJ91580.1|3360537_3361596_+|aspartate-semialdehyde-dehydrogenase	gnl|CDD|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	3.4997e-159
CP032229.1|QBJ94183.1|3340605_3341487_-|XRE-family-transcriptional-regulator	gnl|CDD|376540	pfam01381, HTH_3, Helix-turn-helix. This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within Neisseria gonorrhoeae NGO_0477, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family.	5.50267e-07
CP032229.1|QBJ91566.1|3344852_3345923_+|DUF4157-domain-containing-protein	gnl|CDD|379338	pfam13699, DUF4157, Domain of unknown function (DUF4157). This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. This domain contains an HEXXH motif that is characteristic of many families of metallopeptidases. However, no peptidase activity has been shown for this domain.	6.39258e-26
CP032229.1|QBJ91578.1|3358527_3359106_+|Uma2-family-endonuclease	gnl|CDD|368559	pfam05685, Uma2, Putative restriction endonuclease. This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. A small number of member proteins also contain pfam02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	3.46636e-21
CP032229.1|QBJ91564.1|3342887_3343658_+|SDR-family-oxidoreductase	gnl|CDD|180604	PRK06523, PRK06523, short chain dehydrogenase; Provisional.	3.66484e-104
CP032229.1|QBJ91575.1|3354421_3356701_+|tetratricopeptide-repeat-protein	gnl|CDD|315987	pfam13424, TPR_12, Tetratricopeptide repeat.	0.000290601
CP032229.1|QBJ91579.1|3359260_3360538_+|aspartate-kinase	gnl|CDD|235843	PRK06635, PRK06635, aspartate kinase; Reviewed.	0
CP032229.1|QBJ91565.1|3343661_3344537_-|LysR-family-transcriptional-regulator	gnl|CDD|223656	COG0583, LysR, Transcriptional regulator [Transcription].	2.0243e-37
CP032229.1|QBJ91573.1|3353089_3353689_+|recombination-protein-RecR	gnl|CDD|234616	PRK00076, recR, recombination protein RecR; Reviewed.	4.8627e-124
CP032229.1|QBJ91570.1|3348990_3350376_-|aspartate-aminotransferase-family-protein	gnl|CDD|235687	PRK06062, PRK06062, hypothetical protein; Provisional.	0
CP032229.1|QBJ91568.1|3346766_3347387_-|TetR/AcrR-family-transcriptional-regulator	gnl|CDD|367243	pfam02909, TetR_C, Tetracyclin repressor, C-terminal all-alpha domain.	3.712e-10
CP032229.1|QBJ91569.1|3347378_3349007_+|FAD-dependent-oxidoreductase	gnl|CDD|236199	PRK08244, PRK08244, monooxygenase.	1.14325e-96
CP032229.1|QBJ91574.1|3353681_3354341_+|DUF5063-domain-containing-protein	gnl|CDD|374737	pfam16702, DUF5063, Domain of unknown function (DUF5063).	7.12268e-53
CP032229.1|QBJ94184.1|3351502_3352393_-|SLATT-domain-containing-protein	gnl|CDD|375613	pfam18183, SLATT_2, SMODS and SLOG-associating 2TM effector domain 2. The SLATT domain contains two transmembrane helices. SLATT domains are generally predicted to function as pore-forming effectors in a class of conflict systems which are reliant on the production of second messenger nucleotide or nucleotide derivatives. SLATT domains are predicted to initiate cell suicide responses upon their activation. This SLATT family is the only prokaryotic SLATT family to exist as a standalone domain, with no as-yet discernable genome associations.	3.18775e-101

Protein sequences

>CP032229.1|QBJ91570.1|3348990_3350376_-|aspartate-aminotransferase-family-protein
MTPQPNPEQTPTPDPATGAAVKAADRAHVFHSWSAQDLIDPLAVAGAEGSYFWDYDGNRYLDFTSGLVFTNIGYQHPEVVAAIQEQAAKMTTFAPAFAVEARSEAARLIAERTPGDLDKIFFTNAGADAVEHATRMARLHTGRPKVLSAYRSYHGGTQQAVNLTGDPRRWPSDSGSAGVVHFWAPFLYRSRFYAETEEQECARALEHLETTIAFEGPGTIAAVILETIPGTAGIMIPPPGYLAGVREICDRHGIVFILDEVMAGFGRTGEWFAADLSGVVPDLMTFAKGVNSGYVPLGGVAISPEIADTFATRPYPGGLTYSGHPLACGAAVATLDVMAREGIVENAKHLGETVLGPTLATFAERHPSVGEVRGTGMFWALELVKDRETREPLVPYNASAATNAPMAAFAAAAKKNGLWPFINMNRTHVVPPCNITEPELKEGLAALDAALTTADEFTTSG
>CP032229.1|QBJ91569.1|3347378_3349007_+|FAD-dependent-oxidoreductase
MVHGDRVLAAAGPGVPGGCGPVAGGAALFRVHGDNYNLTRTLFVFRTVFVKTDVDVIVTGAGPVGLALAAELALAGVSVRVLERRDVPDPATRAQSINVPTAQALARRGLLPALEEIQRETLGVPRSRFTGHFAGMSLDPDRVDWADPELAAYTAVEGARMIPQPRLEALLAAHAERLGAAVLRGVEVTSLQDTGAGVVVGTDTGPMRAGWLVGCDGGHSTVRRLAGIAFPGTDPEITGCQAIVDIADPEKLAEGWSWSPRGVYRYGPQPGRVATVEFGGGPADRTAQVTLEDVQSSLRRVSGTDVTLTSLRAAPTRWTDNARQASAYRSGRVLLAGDAAHVHPPFGGQGLNLGMGDAVNLAWKLAAVVSGRAEEALLDTYDAERRPVGAWVLDWTRAQIGVLRGDPKSGALRGVLADLLGTRDGTTYAVKQIAGVTQRLPLPGSHPWTGRYVPDVVLSDGSPLADHAHEGGFLLLDRTPGAVFAESGKGRARIVRDGGTGVAGALIRPDGVVVWASDTTDPAGLEPALRQWAGSGPLSRTS
>CP032229.1|QBJ91568.1|3346766_3347387_-|TetR/AcrR-family-transcriptional-regulator
MDHVVETALGIIATEGYEALTMRRLSAALDTGPASLYAHVVNKADLDELLIGRLCARLTLPAPDPASWRDQLRGVCEALRDQYLQYPGISRAALAMAPTDLEALRVSEGMLAILLTAGIAPQRAAWTIDALLLYVAAHCLELSVAHRRAEDGDEVWPADRTDLLHRLTTLPAAAFPHTTRHAAELTTGTTRDRFDFTVGLMINGLG
>CP032229.1|QBJ91567.1|3345919_3346612_-|GntR-family-transcriptional-regulator
MPGYGAVTRSTLRQQIADALRDEVLAGRLLPGRAFTVKEIADLYGVSATPVREALVDLSAQALLEADHHRGFRVPEYSLADYRGMIEARSLVTEGMFRVLGQGHPAFADPGNPDTAAALATVRRRGEEAQRANAAGDLTVLIGYDLRFWRELSVLFGNPYLAEFLHRLRVRSWVCAVQHLRRLPEVRGRLWAGHIDLVDALSAHDPEAARAIVAAANAHALEMVEELAGG
>CP032229.1|QBJ91566.1|3344852_3345923_+|DUF4157-domain-containing-protein
MPISQHTRGERESGKTGRRTPAAPEKATTRPGPGSLAGLQGAVGNAAVVRMVQRAAPETHRHGAGCGHEEEADVQRAAVEEAVQRAAVHDVLSGSGRPLDQPTRTEMEGRLGADLSDVRVHTGRAATDSAAQMGARAYTSGSHIVIGKGGGDRHTLAHELTHVIQQRNGPVSGTDTGQGYSVSDPSDRFERAAEANARKVMSGPAPGGQGRTGEGGGDPGASRPAAGAPVQRKLETVTTESATVSHYAPTKEDAPVLNDLGIKRPKVVTGSIDPTSTKGRPAARPSTHWTTPCPTRPPTARAARRTAAGRPTSAWAARLRLPRAGSFCPRPSIPRTTVPTPTTPRAADDNDDAMST
>CP032229.1|QBJ91565.1|3343661_3344537_-|LysR-family-transcriptional-regulator
MSLRQFEYALAVAEEGSVTAAAERLRVAQPSMSQQIRGLERELGVELFARTPSGLTPTVVGRAFLREAQVAVSAARRATATARAGAAELVGELTVAAQMGFGTRQLPEALGELRRRFPRLEVTLSEEPSSAELDRLCRRGVLDLALMAKCDRTPADAHRLGEEEFVVVLGEGHQQLGSPRVELRDLKGEPWVRFDRDSALDGVLVEALRETDPEPDTVARVSQTATAVRWAAQGLGATLVPASAVPASHEHLARPVSPAVAQPVIAVVRNPAGPAETALLEFLRQENWSGS
>CP032229.1|QBJ91564.1|3342887_3343658_+|SDR-family-oxidoreductase
MATTENGTGTPELKGKRALVTGGTRGIGAGIVARLLEAGAEVLTTARSEPDEVPEGVRFVAADVRSREGAEELAAAAVDVLGGVDILVHNAGGASPYESATAIPDEVWLDALNLNLLASVRLDALLAPAMRERGSGAIVHVSSAAVPVAFPPFLHYTVAKAGLENYSKGLAAELAPAGVRVNTVTPGRVTTPGGEATREQWAKLDPTQSGEVSLVPLGRDGEPDDIARAVLFLVSDRASWVTGSNFVIDGGEFPRG
>CP032229.1|QBJ91563.1|3342035_3342686_-|hypothetical-protein
MACDLWLVPLVDVLCHTPDNPFAEELAVYNDALATAGLPPVPVYQYMPGLNGEVAPVAGFDYDALHFLRRAHLLQLCGLPVTPVGELGGDYEQLLEMFESTAQQSHLVWHYDHAGAYVPLDFTQPLSNDELLAGGGPLGSSHALLRELEQVAPAIGIDPANPPAAPTPPSAPTELEEPAVPAPYDPSPFARERHVWLGLHAAATRSLAQGSMIVFS
>CP032229.1|QBJ91562.1|3341611_3342043_+|hypothetical-protein
MNTQSHADIQWVPAMGIQLRRAGVQFDAVRVDGDRGRDIADRMARMTGGDPGPVVESGSGRRCVYFLVAPGSTAHHAWPAEATRLTSGPYRVSYIPVPALDGQTWPLGWRFPPTAPDRFVHTLLLRAALLDGSQGPPQPPELN
>CP032229.1|QBJ94183.1|3340605_3341487_-|XRE-family-transcriptional-regulator
MARAANKTAASGTARMIATFAKARREQLGLTQEELGRLIGYTASAISAMETCAQPASDKMLMELERVLGDGMGIFEMARKFILLDKYPAQFQDFALMEAEAVSLSSYETYVIAGLFQTENYARALIGGGSPALSKAEVDELVDARIARRALFDRTGPTPLIETVLDESALLRTIGSQDIMSEQLYALAEDAERDNVSLQVLRLNRGAKGAHAGTDGDMTLVTTSEHHHVVYLEAQDESVLVSDPVKVARLTHRYAKIRSQALSPDDSVSLLRKLAGEARNDQHPPVVQVELQQ
>CP032229.1|QBJ94184.1|3351502_3352393_-|SLATT-domain-containing-protein
MRRGGPEADGVWRSADGTRRAGSGTDGLPAGGPGGDGAWRGADGGDPGVSGGQPGDRGARAAAPDEVSEDVARLAGPGGDLVGRELPLGDWGEPAERLGELFRWVEAGALRTAEWYLADRVWRRRAARGLRGGTAAGVVVGAALPLLDATGAVAGCAPWGYLALLLGAACAGADRCFGLTSGWMRDLATAQAVQRRLQTLQFDWASESAREVLGPAEGTAGEAAERCLGILRRFSEDVTELVRTETSDWMQEFRGGRPPVSPPPPPSRPADPAPVSRYLPPAPRPNMPRQRPPDPR
>CP032229.1|QBJ91572.1|3352695_3353037_+|YbaB/EbfC-family-nucleoid-associated-protein
MIPGGGQPNMQQLLQQAQKMQQDLARAQEELANTEVEGQAGGGLVKATVTGSGDLRALKIDPKAVDPEDTETLADLVVAAVQAANENAQALQQQKLGPLAEGLGGGGIPGLPF
>CP032229.1|QBJ91573.1|3353089_3353689_+|recombination-protein-RecR
MYEGVVQDLIDELGRLPGVGPKSAQRIAFHVLQAEPTDVKRLAHALLEVKAKVRFCAACGNVAQEELCNICRDPRRDPSVICVVEEPKDVVAIERTREFRGKYHVLGGAISPIEGVGPDDLRIRELLARLADGTVTELILATDPNLEGEATATYLARMIKPMGLKVTRLASGLPVGGDLEYADEVTLGRAFEGRRLLDV
>CP032229.1|QBJ91574.1|3353681_3354341_+|DUF5063-domain-containing-protein
MSDATLHAIAQNPDDFAVQIADQIESFLVAVTEVAKGDEPGSTVPFLLLEVSQLLLAGGRLGAHEDFLPDERYEPDPGPEPDADGLRENLARLLDPVDVYSEVFDPYAPRTAPVAARISDDLADVITDLGHGMVHYRAGRTAEALWWWQFSYFSNWGPTASAVLRALQSVLIHVRLNQPLEELDGLDTDQDLGDEALEVEAGRVMAEEIGTPLGIRQVR
>CP032229.1|QBJ91575.1|3354421_3356701_+|tetratricopeptide-repeat-protein
MSALFDRRPVPAADASGAGAIAAGGSIAQALTGPGAIALHIENVGMLLPDACPPAESVSCPPRLTNLPFRAELFVGRSDELGLLRAAPATPGRPLAQVLRGLGGIGKSTLAARWSVECGPTHAPVWWIPAGSRSAIDAGVAALAAALQPSLVPLLPPEQMTEWGSRWLASHSGWLLVLDDVTNPADVEPLLSRAPSGRFLITSRRATGWHGVAEEIPLDVLSCDDAVRIFTRVRGGEDSDAAELCEELGCLPLAVTQAAAYCLETDCTVRVYLDDLAAYPDEMYAETYEGGDHERTVARVWHVTLDRLTNDPLAVRLLLTMAWYAPDGIPRGLFAHLGTPLAVRRALGRLAAHSMITLSGDTVTVHRLVQAVSRTRADADRHRNPEAIGDACAAAVKALARAVPEDVDDPSAWPAMRSLLPHVQALAEHVRPEEDTAAMAYVLTRTGDYMLTAGIRLAGGAYGLLQRAEAACVRHHGPGGEQTLYTRVLLARATRMLKSSEEAAPVAEEVLADCTRVLGPDHEVTLGALSNMHQVASLQGDTERALRLAEACLAGVARLRGAEARSTFEARKKLVMALTAVGEMTRADDLCDELLADCSRALGEEDPSTLSVRSLRTALAGQRELPETLIKLMAGVHSVGEEDEEGLIAALRVLIQQVGAVEPEQFTRATEEDVSAAERDLDTCRRVLGDDHADTVVARLVLLQVYAATRDPRYAEPAKDLLMEVLSVISANESALAFMLRVFGALHTVIDELPRPPDE
>CP032229.1|QBJ91576.1|3356756_3357182_+|hypothetical-protein
MTLKPWAWAGLGICGAGVATLVGFAFVDLGTADQVASVGGGAVGLIGFALAVIAQFGGTSASPSAPSGPSASARDVHASGERAIAAGGSIGVASTGGAASPGSPLPPRAPASGAPGPGSVTASGTGSIAAGGDIGSASTGN
>CP032229.1|QBJ91577.1|3357505_3358477_+|hypothetical-protein
MAKSGYGKRSAGDENPYGDPDFAHLSPRDREIAVFVDHLDDGHAMGYKAIAAVHPRYGQQAVRTSLKRVTAAGHLRHIREHLTVEDNSMRWVTRTYWSRTPRSPEWWAEFVRERKGLDVTDQYESGLARAAEAAPAALDEQLPEEPSDEPGAAYRTLAGLRDADPRIALSASDCRSLESLAARWLALGATPQEITKALTDGLPPAVTNPGGLARRRLEDKMPPTKAKIRQRGGRRARVSRVIMACATCDADERTTEIIDGICRECHAEIEADEAAEMEGLPVGYVPETFLRDPADDPGVVDVTHWAAELRRAAGLRPRAGRDV
>CP032229.1|QBJ91578.1|3358527_3359106_+|Uma2-family-endonuclease
MTPRTEDRPQMSVEEFEELERHAPETVRLEFLNGKVQVKPVTDGNHDHIIAWLQRLCMQHRPELWLYGDRGMKVERYRKGRARPDGVLAPFGFPAGHGDWSDAGGVLMAVEVTSHDSDTNQRDRVEKPGGYAAAGIPVYLLIDRDDGSVVVYNQPEDGRYLHAEKSPFGASVELPHPVDIILDTAPLKELVD
>CP032229.1|QBJ91579.1|3359260_3360538_+|aspartate-kinase
MGLVVQKYGGSSVADAEGIKRVAKRIVEAKKNGNQVVVVVSAMGDTTDELIDLAEQVSPMPAGREFDMLLTAGERISMALLAMAIKKLGHEAQSFTGSQAGVITDSVHNKARIIDVTPGRIRTALDEGNIAIVAGFQGVSQDKKDITTLGRGGSDTTAVALAAALDAEVCEIYTDVDGVFTADPRVVKKARKIDWISFEDMLELAASGSKVLLHRCVEYARRYNIPIHVRSSFSGLRGTWVSSEPIEQGEQQVEQAIISGVAHDTSEAKITVVGVPDKPGEAAAIFRTIADAEINIDMVVQNVSAASTGLTDISFTLPKTEGRKAIDALERNRPGIGFESLRYDDQIGKISLVGAGMKTNPGVTASFFEALSDAGVNIELISTSEIRISVVTRADEVPEAVRAVHTAFGLDSDTDEAVVYGGTGR
>CP032229.1|QBJ91580.1|3360537_3361596_+|aspartate-semialdehyde-dehydrogenase
MARTGRPTLAVVGATGAVGAVMLQILSQRADIWGEIRLLASPRSAGRKLAVRGEEVEVAALTEDAFDGVDVAMFDVPDEVAARWAPVAVARGAVVVDNSGAFRMDPEVPLVVPEVNPHTARMRPRGIVANPNCTTLSMIVALGALHAEYGLRELVVSSYQAVSGAGRAGIETLRAQLSLVAGTDLGTAPGDVRRAVGELTGPFPEPVALNVVPWAGSLREDGWSSEEMKVRDETRKILGLAALPVAVTCVRVPVLTTHSLTVHARFQDEVTVDGAREILATAPGVVLCDDPAAGEYPTPADVVGTDPTWVGRVRRALDDPTALELFVCGDNLRKGAALNTAQIAELVAAEMM

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
CP032229_1	1.8|14577|25|CP032229|CRT	14577-14601	25	CP032229.1	6336975-6336999	0	1.0
CP032229_1	1.9|14620|50|CP032229|CRT	14620-14669	50	CP032229.1	6336907-6336956	0	1.0
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	CP032229.1	6336856-6336888	0	1.0
CP032229_3	3.3|3350820|18|CP032229|CRT	3350820-3350837	18	CP032229.1	2170557-2170574	1	0.944
CP032229_3	3.4|3350859|18|CP032229|CRT	3350859-3350876	18	CP032229.1	2307125-2307142	1	0.944
CP032229_3	3.5|3350898|18|CP032229|CRT	3350898-3350915	18	CP032229.1	742690-742707	1	0.944
CP032229_1	1.5|14411|32|CP032229|CRT	14411-14442	32	CP032229.1	6336967-6336998	2	0.938
CP032229_4	4.1|5449657|20|CP032229|CRISPRCasFinder	5449657-5449676	20	CP032229.1	388702-388721	2	0.9
CP032229_5	5.3|6337134|31|CP032229|CRT	6337134-6337164	31	CP032229.1	6336967-6336997	2	0.935

1. spacer 1.8|14577|25|CP032229|CRT matches to position: 6336975-6336999, mismatch: 0, identity: 1.0

ggggcaggtggccccggtaggacga	CRISPR spacer
ggggcaggtggccccggtaggacga	Protospacer
*************************

2. spacer 1.9|14620|50|CP032229|CRT matches to position: 6336907-6336956, mismatch: 0, identity: 1.0

ggccgggcgggtggccggggcgggacgggcgggtggccggggcggggcga	CRISPR spacer
ggccgggcgggtggccggggcgggacgggcgggtggccggggcggggcga	Protospacer
**************************************************

3. spacer 1.10|14688|33|CP032229|CRT matches to position: 6336856-6336888, mismatch: 0, identity: 1.0

gggcgcctccccggccggcgcgccggggcccgg	CRISPR spacer
gggcgcctccccggccggcgcgccggggcccgg	Protospacer
*********************************

4. spacer 3.3|3350820|18|CP032229|CRT matches to position: 2170557-2170574, mismatch: 1, identity: 0.944

actcggtggggcgggggc	CRISPR spacer
acgcggtggggcgggggc	Protospacer
** ***************

5. spacer 3.4|3350859|18|CP032229|CRT matches to position: 2307125-2307142, mismatch: 1, identity: 0.944

gctcggtggggtgggggc	CRISPR spacer
gctcggtggggtgcgggc	Protospacer
************* ****

6. spacer 3.5|3350898|18|CP032229|CRT matches to position: 742690-742707, mismatch: 1, identity: 0.944

gcccggtgggacgggggc	CRISPR spacer
gccgggtgggacgggggc	Protospacer
*** **************

7. spacer 1.5|14411|32|CP032229|CRT matches to position: 6336967-6336998, mismatch: 2, identity: 0.938

gggccgggggccccggtaggacgaggctcgcc	CRISPR spacer
gggcaggtggccccggtaggacgaggctcgcc	Protospacer
**** ** ************************

8. spacer 4.1|5449657|20|CP032229|CRISPRCasFinder matches to position: 388702-388721, mismatch: 2, identity: 0.9

tggatgtcgggcacatggcc	CRISPR spacer
tgggcgtcgggcacatggcc	Protospacer
***..***************

9. spacer 5.3|6337134|31|CP032229|CRT matches to position: 6336967-6336997, mismatch: 2, identity: 0.935

ggcgagcctcgtcctaccggggcccccggcc	CRISPR spacer
ggcgagcctcgtcctaccggggccacctgcc	Protospacer
************************ ** ***

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP015585	Roseomonas gilardii strain U14-5 plasmid 1, complete sequence	33222-33244	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP015587	Roseomonas gilardii strain U14-5 plasmid 3, complete sequence	35969-35991	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NC_016113	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence	1596025-1596047	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NC_017585	Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence	217245-217267	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP050837	Klebsiella pneumoniae strain Bckp021 plasmid pBckp021-3, complete sequence	70977-70999	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP033823	Klebsiella sp. FDAARGOS_511 plasmid unnamed1, complete sequence	83744-83766	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	AP021850	Deinococcus grandis ATCC 43672 plasmid: pDEGR-1 DNA, complete genome	293538-293560	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP008843	Klebsiella michiganensis strain M1 plasmid pKOXM1B, complete sequence	63548-63570	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP024642	Klebsiella michiganensis strain F107 plasmid unnamed2, complete sequence	75787-75809	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP042547	Klebsiella michiganensis strain C52 plasmid pC52_002, complete sequence	2434-2456	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP018361	Klebsiella oxytoca strain CAV1752 plasmid pCAV1752-278, complete sequence	66470-66492	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP026718	Klebsiella oxytoca strain AR_0028 plasmid unitig_3_pilon, complete sequence	24653-24675	2	0.913
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP044111	Klebsiella michiganensis strain FDAARGOS_647 plasmid unnamed2	198771-198793	2	0.913
CP032229_1	1.8|14577|25|CP032229|CRT	14577-14601	25	NC_007974	Cupriavidus metallidurans CH34 megaplasmid, complete sequence	138713-138737	3	0.88
CP032229_1	1.8|14577|25|CP032229|CRT	14577-14601	25	NZ_CP046333	Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3	908514-908538	3	0.88
CP032229_1	1.8|14577|25|CP032229|CRT	14577-14601	25	NZ_CP044976	Hydrogenophaga sp. PBL-H3 substr. PBL-H3(B2) plasmid pPBL-H3_B2-1, complete sequence	245973-245997	3	0.88
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP016082	Streptomyces sp. SAT1 plasmid unnamed2, complete sequence	294100-294122	3	0.87
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NC_007960	Nitrobacter hamburgensis X14 plasmid 2, complete sequence	123648-123670	3	0.87
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP030074	Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence	160038-160060	3	0.87
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP030127	Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence	1088219-1088241	3	0.87
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NZ_CP021082	Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence	17108-17130	3	0.87
CP032229_5	5.6|6337284|23|CP032229|CRT	6337284-6337306	23	NC_016585	Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence	964725-964747	3	0.87
CP032229_1	1.4|14365|28|CP032229|CRT	14365-14392	28	NZ_CP040822	Paraoceanicella profunda strain D4M1 plasmid pD4M1D, complete sequence	67631-67658	4	0.857
CP032229_5	5.4|6337183|28|CP032229|CRT	6337183-6337210	28	NZ_CP040822	Paraoceanicella profunda strain D4M1 plasmid pD4M1D, complete sequence	67631-67658	4	0.857
CP032229_1	1.4|14365|28|CP032229|CRT	14365-14392	28	AB967974	Aurantimonas phage AmM-1 DNA, complete sequence	25140-25167	6	0.786
CP032229_1	1.6|14461|33|CP032229|CRT	14461-14493	33	NZ_CP021409	Celeribacter manganoxidans strain DY25 plasmid pDY25-E, complete sequence	49401-49433	6	0.818
CP032229_3	3.2|3350769|30|CP032229|CRT	3350769-3350798	30	NC_003903	Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence	77325-77354	6	0.8
CP032229_5	5.4|6337183|28|CP032229|CRT	6337183-6337210	28	AB967974	Aurantimonas phage AmM-1 DNA, complete sequence	25140-25167	6	0.786
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_CP009295	Novosphingobium pentaromativorans US6-1 plasmid pLA5, complete sequence	270-302	7	0.788
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_CP010862	Marinovum algicola DG 898 plasmid pMaD7	18998-19030	7	0.788
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NC_015579	Novosphingobium sp. PP1Y plasmid Lpl, complete sequence	86710-86742	7	0.788
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_CP025431	Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence	45953-45985	7	0.788
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_AP014705	Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence	811583-811615	7	0.788
CP032229_1	1.6|14461|33|CP032229|CRT	14461-14493	33	NZ_CP023152	Mycobacterium chimaera strain FLAC0070 plasmid pFLAC0070_1, complete sequence	36238-36270	8	0.758
CP032229_1	1.6|14461|33|CP032229|CRT	14461-14493	33	NZ_AP012556	Mycobacterium avium subsp. hominissuis TH135 plasmid pMAH135, complete sequence	105118-105150	8	0.758
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_CP022363	Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence	85143-85175	8	0.758
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NC_009427	Novosphingobium aromaticivorans DSM 12444 plasmid pNL2, complete sequence	212932-212964	8	0.758
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	MN304824	Catenulispora phage 69_17, complete genome	36486-36518	8	0.758
CP032229_3	3.2|3350769|30|CP032229|CRT	3350769-3350798	30	NZ_CP040937	Hymenobacter sp. DG01 plasmid unnamed, complete sequence	237668-237697	8	0.733
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_CP045548	Streptomyces sp. SYP-A7193 plasmid unnamed1, complete sequence	95181-95213	9	0.727
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_CP021082	Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence	175226-175258	13	0.606
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_CP054029	Rhizobium sp. JKLM19E plasmid pPR19E02, complete sequence	70330-70362	14	0.576
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_CP020613	Paracoccus contaminans strain RKI 16-01929T=LMG 29738T=CCM 8701T=CIP 111112T plasmid unnamed, complete sequence	33665-33697	14	0.576
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_CP023408	Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence	306739-306771	15	0.545
CP032229_1	1.10|14688|33|CP032229|CRT	14688-14720	33	NZ_CP040820	Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence	254147-254179	16	0.515

1. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP015585 (Roseomonas gilardii strain U14-5 plasmid 1, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgccccgccctcccggcgggccg	Protospacer
********** *********** 

2. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP015587 (Roseomonas gilardii strain U14-5 plasmid 3, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgccccgccctcccggcgggccg	Protospacer
********** *********** 

3. spacer 5.6|6337284|23|CP032229|CRT matches to NC_016113 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCAT, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgccccgcccgcccagcgggccc	Protospacer
**************.*******.

4. spacer 5.6|6337284|23|CP032229|CRT matches to NC_017585 (Streptomyces cattleya NRRL 8057 = DSM 46488 plasmid pSCATT, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgccccgcccgcccagcgggccc	Protospacer
**************.*******.

5. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP050837 (Klebsiella pneumoniae strain Bckp021 plasmid pBckp021-3, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgacccggccgcccggcgggcct	Protospacer
** **** ***************

6. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP033823 (Klebsiella sp. FDAARGOS_511 plasmid unnamed1, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgacccggccgcccggcgggcct	Protospacer
** **** ***************

7. spacer 5.6|6337284|23|CP032229|CRT matches to AP021850 (Deinococcus grandis ATCC 43672 plasmid: pDEGR-1 DNA, complete genome) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgccccgcccgcctggagggcct	Protospacer
*************.** ******

8. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP008843 (Klebsiella michiganensis strain M1 plasmid pKOXM1B, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgacccggccgcccggcgggcct	Protospacer
** **** ***************

9. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP024642 (Klebsiella michiganensis strain F107 plasmid unnamed2, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgacccggccgcccggcgggcct	Protospacer
** **** ***************

10. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP042547 (Klebsiella michiganensis strain C52 plasmid pC52_002, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgacccggccgcccggcgggcct	Protospacer
** **** ***************

11. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP018361 (Klebsiella oxytoca strain CAV1752 plasmid pCAV1752-278, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgacccggccgcccggcgggcct	Protospacer
** **** ***************

12. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP026718 (Klebsiella oxytoca strain AR_0028 plasmid unitig_3_pilon, complete sequence) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgacccggccgcccggcgggcct	Protospacer
** **** ***************

13. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP044111 (Klebsiella michiganensis strain FDAARGOS_647 plasmid unnamed2) position: , mismatch: 2, identity: 0.913

cgccccgcccgcccggcgggcct	CRISPR spacer
cgacccggccgcccggcgggcct	Protospacer
** **** ***************

14. spacer 1.8|14577|25|CP032229|CRT matches to NC_007974 (Cupriavidus metallidurans CH34 megaplasmid, complete sequence) position: , mismatch: 3, identity: 0.88

ggggcaggtggccccggtaggacga	CRISPR spacer
cgggcaggcggccccggtaggtcga	Protospacer
 *******.************ ***

15. spacer 1.8|14577|25|CP032229|CRT matches to NZ_CP046333 (Cupriavidus metallidurans strain FDAARGOS_675 plasmid unnamed3) position: , mismatch: 3, identity: 0.88

ggggcaggtggccccggtaggacga	CRISPR spacer
cgggcaggcggccccggtaggtcga	Protospacer
 *******.************ ***

16. spacer 1.8|14577|25|CP032229|CRT matches to NZ_CP044976 (Hydrogenophaga sp. PBL-H3 substr. PBL-H3(B2) plasmid pPBL-H3_B2-1, complete sequence) position: , mismatch: 3, identity: 0.88

ggggcaggtggccccggtaggacga	CRISPR spacer
ggggcaggtggccccggtgggttga	Protospacer
******************.** .**

17. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP016082 (Streptomyces sp. SAT1 plasmid unnamed2, complete sequence) position: , mismatch: 3, identity: 0.87

cgccccgcccgcccggcgggcct	CRISPR spacer
caccccgcccgcccggcgggcgg	Protospacer
*.*******************  

18. spacer 5.6|6337284|23|CP032229|CRT matches to NC_007960 (Nitrobacter hamburgensis X14 plasmid 2, complete sequence) position: , mismatch: 3, identity: 0.87

cgccccgcccgcccggcgggcct	CRISPR spacer
cgccccgcccgccctgcgggctg	Protospacer
************** ******. 

19. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP030074 (Streptomyces sp. ZFG47 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.87

cgccccgcccgcccggcgggcct	CRISPR spacer
cgccccgcccgtccggcgggctg	Protospacer
***********.*********. 

20. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP030127 (Indioceanicola profundi strain SCSIO 08040 plasmid unnamed1, complete sequence) position: , mismatch: 3, identity: 0.87

cgccccgcccgcccggcgggcct	CRISPR spacer
tgccccgcccgcgcggcgggccc	Protospacer
.*********** *********.

21. spacer 5.6|6337284|23|CP032229|CRT matches to NZ_CP021082 (Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence) position: , mismatch: 3, identity: 0.87

cgccccgcccgcccggcgggcct	CRISPR spacer
cgccccgcccgcccggcgtgctg	Protospacer
****************** **. 

22. spacer 5.6|6337284|23|CP032229|CRT matches to NC_016585 (Azospirillum lipoferum 4B plasmid AZO_p1, complete sequence) position: , mismatch: 3, identity: 0.87

cgccccgcccgcccggcgggcct	CRISPR spacer
ggccccgcccgccgggcgggccg	Protospacer
 ************ ******** 

23. spacer 1.4|14365|28|CP032229|CRT matches to NZ_CP040822 (Paraoceanicella profunda strain D4M1 plasmid pD4M1D, complete sequence) position: , mismatch: 4, identity: 0.857

cgcggaaggagggccgccgggcgggacg	CRISPR spacer
cggtgaaggaggggcgccgggcaggacg	Protospacer
**  ********* ********.*****

24. spacer 5.4|6337183|28|CP032229|CRT matches to NZ_CP040822 (Paraoceanicella profunda strain D4M1 plasmid pD4M1D, complete sequence) position: , mismatch: 4, identity: 0.857

cgtcccgcccggcggccctccttccgcg	CRISPR spacer
cgtcctgcccggcgcccctccttcaccg	Protospacer
*****.******** *********  **

25. spacer 1.4|14365|28|CP032229|CRT matches to AB967974 (Aurantimonas phage AmM-1 DNA, complete sequence) position: , mismatch: 6, identity: 0.786

cgcggaaggagggccgccgggcgggacg	CRISPR spacer
tggtcaaggagggccgcccggcgcgacg	Protospacer
.*   ************* **** ****

26. spacer 1.6|14461|33|CP032229|CRT matches to NZ_CP021409 (Celeribacter manganoxidans strain DY25 plasmid pDY25-E, complete sequence) position: , mismatch: 6, identity: 0.818

cgcggggcgaggcccgccgggtgg-ggcggggcg	CRISPR spacer
cgccgggcgaggcccgccgggcggtggcgcaac-	Protospacer
*** *****************.** **** ..* 

27. spacer 3.2|3350769|30|CP032229|CRT matches to NC_003903 (Streptomyces coelicolor A3(2) plasmid SCP1, complete sequence) position: , mismatch: 6, identity: 0.8

gggtgcgggtgggaacggtggggcgggggc	CRISPR spacer
cggtgcgggtgggggcggtggggccgtgtc	Protospacer
 ************..********* * * *

28. spacer 5.4|6337183|28|CP032229|CRT matches to AB967974 (Aurantimonas phage AmM-1 DNA, complete sequence) position: , mismatch: 6, identity: 0.786

cgtcccgcccggcggccctccttccgcg	CRISPR spacer
cgtcgcgccgggcggccctccttgacca	Protospacer
**** **** *************   *.

29. spacer 1.10|14688|33|CP032229|CRT matches to NZ_CP009295 (Novosphingobium pentaromativorans US6-1 plasmid pLA5, complete sequence) position: , mismatch: 7, identity: 0.788

gggcgcctccccggccggcgcgccggggcccgg---	CRISPR spacer
gggcgcctcccctgcccgcgcgcc---gctcgacgt	Protospacer
************ *** *******   **.**.   

30. spacer 1.10|14688|33|CP032229|CRT matches to NZ_CP010862 (Marinovum algicola DG 898 plasmid pMaD7) position: , mismatch: 7, identity: 0.788

gggcgcctccccggccggcgcgccggggcccgg	CRISPR spacer
gccccccgccccggccgccgcgccggggcctcg	Protospacer
*  * ** ********* ************. *

31. spacer 1.10|14688|33|CP032229|CRT matches to NC_015579 (Novosphingobium sp. PP1Y plasmid Lpl, complete sequence) position: , mismatch: 7, identity: 0.788

gggcgcctccccggccggcgcgccggggcccgg---	CRISPR spacer
gggcgcctcccctgcccgcgcgcc---gctcgacgt	Protospacer
************ *** *******   **.**.   

32. spacer 1.10|14688|33|CP032229|CRT matches to NZ_CP025431 (Paracoccus zhejiangensis strain J6 plasmid pPZ01, complete sequence) position: , mismatch: 7, identity: 0.788

gggcgcctccccggccggcgcgccggggcccgg	CRISPR spacer
gggcgccagcccggccggcgcgccatcgaccag	Protospacer
*******  ***************.  * **.*

33. spacer 1.10|14688|33|CP032229|CRT matches to NZ_AP014705 (Methylobacterium aquaticum strain MA-22A plasmid pMaq22A_1p, complete sequence) position: , mismatch: 7, identity: 0.788

gggcgcctccccggccggcgcgccggggcccgg	CRISPR spacer
gagcgcctcctcggctggcgcgccggcacgccg	Protospacer
*.********.****.********** .* * *

34. spacer 1.6|14461|33|CP032229|CRT matches to NZ_CP023152 (Mycobacterium chimaera strain FLAC0070 plasmid pFLAC0070_1, complete sequence) position: , mismatch: 8, identity: 0.758

cgcggggcgaggcccgccgggtggggcggggcg	CRISPR spacer
ggccgggcggggcccgccgggtgggctggctcc	Protospacer
 ** *****.*************** .**  * 

35. spacer 1.6|14461|33|CP032229|CRT matches to NZ_AP012556 (Mycobacterium avium subsp. hominissuis TH135 plasmid pMAH135, complete sequence) position: , mismatch: 8, identity: 0.758

cgcggggcgaggcccgccgggtggggcggggcg	CRISPR spacer
ggccgggcggggcccgccgggtgggctggctcc	Protospacer
 ** *****.*************** .**  * 

36. spacer 1.10|14688|33|CP032229|CRT matches to NZ_CP022363 (Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence) position: , mismatch: 8, identity: 0.758

gggcgcctccccggccggcgcgccggggcccgg	CRISPR spacer
ttcggcctcccccgccgccgcgccggggccggc	Protospacer
    ******** **** ************ * 

37. spacer 1.10|14688|33|CP032229|CRT matches to NC_009427 (Novosphingobium aromaticivorans DSM 12444 plasmid pNL2, complete sequence) position: , mismatch: 8, identity: 0.758

gggcgcctccccggccggcgcgccggggcccgg	CRISPR spacer
tggcgcctcccccgcccgcgcgccgatggacgt	Protospacer
 *********** *** ********. *  ** 

38. spacer 1.10|14688|33|CP032229|CRT matches to MN304824 (Catenulispora phage 69_17, complete genome) position: , mismatch: 8, identity: 0.758

gggcgcctccccggccggcgcgccggggcccgg	CRISPR spacer
cgccggtgccgcggccggcgcgctggggcccgc	Protospacer
 * ** . ** ************.******** 

39. spacer 3.2|3350769|30|CP032229|CRT matches to NZ_CP040937 (Hymenobacter sp. DG01 plasmid unnamed, complete sequence) position: , mismatch: 8, identity: 0.733

gggtgcgggtgggaacggtggggcgggggc	CRISPR spacer
cctacctggtgggcacggcggggcgggggc	Protospacer
     * ****** ****.***********

40. spacer 1.10|14688|33|CP032229|CRT matches to NZ_CP045548 (Streptomyces sp. SYP-A7193 plasmid unnamed1, complete sequence) position: , mismatch: 9, identity: 0.727

gggcgcctccccggccggcgcgccggggcccgg	CRISPR spacer
accagtcctcccggtcggcgcgccggggccggg	Protospacer
.   *.*..*****.*************** **

41. spacer 1.10|14688|33|CP032229|CRT matches to NZ_CP021082 (Deinococcus ficus strain CC-FR2-10 plasmid pDFI1, complete sequence) position: , mismatch: 13, identity: 0.606

-----gggcgcctccccggccggcgcgccggggcccgg	CRISPR spacer
cgggtgatgggcgcgccggccggggggcc---gccc--	Protospacer
     *.  * * * ******** * ***   ****  

42. spacer 1.10|14688|33|CP032229|CRT matches to NZ_CP054029 (Rhizobium sp. JKLM19E plasmid pPR19E02, complete sequence) position: , mismatch: 14, identity: 0.576

gggcgcctccccggccggcgcgccggggcccgg----------	CRISPR spacer
-------ttcggcgccggcgcgccgg---ccggggcggtcgac	Protospacer
       *.*   *************   ****          

43. spacer 1.10|14688|33|CP032229|CRT matches to NZ_CP020613 (Paracoccus contaminans strain RKI 16-01929T=LMG 29738T=CCM 8701T=CIP 111112T plasmid unnamed, complete sequence) position: , mismatch: 14, identity: 0.576

gggcgcctccccggccggcgcgccggggcccgg----	CRISPR spacer
----gcccgccccggcgcggcggccggggcgggcggg	Protospacer
    ***. *** * **  *** * *** * **    

44. spacer 1.10|14688|33|CP032229|CRT matches to NZ_CP023408 (Streptomyces fungicidicus strain TXX3120 plasmid p1, complete sequence) position: , mismatch: 15, identity: 0.545

gggcgcctccccggccggcgcgccggggcccgg---	CRISPR spacer
---ccgggtcccggcgcgccggctgggtcccgtcgc	Protospacer
   *    .******  **  **.*** ****    

45. spacer 1.10|14688|33|CP032229|CRT matches to NZ_CP040820 (Paraoceanicella profunda strain D4M1 plasmid pD4M1B, complete sequence) position: , mismatch: 16, identity: 0.515

-----gggcgcctccccggccggcgcgccggggcccgg	CRISPR spacer
tcgggaaccggcgcgccggccgggggcctgcgg-----	Protospacer
     .. ** * * ******** *  *.* **     

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	586925 : 616010	22	Moraxella_phage(33.33%)	tail,plate,transposase	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>CP032229|586925:616010|DBSCAN-SWA
GCTAGGTGTATTGATCACGAGCGTTGTTGACGCGGCTGATCGGTGGGTGGCCTCCGAGTGCGGTGTGGCAGCGGTGGTGGTTGTCGGTGTGGAGGAAGTCTGCCAGGGCGTCGGTGCGTTCGGTGTTGGTGGTGTAGGGCCGCTGGTAGGCCCATTCGTCGAGCAGGGTGCGGTTGAAGCGTTCGACCTTGCCGTTGGTCTGCGGCCGGTAGGGGCGAGTCAGCTTGCCGGCCGCACCGATCTCGGTGAGCACCTTTTTCCAGGCCAGGCCCTTGCGGTAGGCCCAGGCGTTGTCGGTCAGGACCCGCTCGATCCGGTCGATGCCCTGGGCGTGGAAGAAGGCGGCCGCGCGGGTCAGGAAGCCCGCGCAGGTCGCGGCTTTCTCGTCGGGGTGGATCTCGCTGTAGGCCAGGCGGGAGTGGTCGTCGACGGCGGAGTGGACGTAGTCGAAGCCCATGCCGCGGATCGGGCGGCCGGCCTCGCGGCCGTGGGTCTTGTGGCCGCCGCCGTCGGGGATCCGGCCCAGCTTCTTCACGTCCACGTGGATCAGCTCGCCGGGCCGGTCACGCTCGTAACGGCGGATGACGGTGCCGGTCGGCCGGTCGATCCAGGCCAACTGGTTGAGGCGGTGGCGGGTCAGGATCCGGTGCACGGTCGAGGTGGGAAGGCCCACGATCGGGCCGATCCGGGCCGGGCCCAGCTTGCGGCTCTGCCGCAGGTCGCAGACGCGGTCTTCCACCGCGGACGCGGTCCGGTGCGGCGTCGTGCGAGGTCGGCTGGAGCGGTCCTGCAGTCCCGCCTCGCCCTCGGTCCGCCACCGGCGGATCCATTTATGGGCGGTGGCGCGGGAGATACCCATCTCGGCGGCCACATGAGCGACCGGACGGCCTGAGCGGACACGTTCGACCAGCAGCCTCCTACCGAAGACGGTCAGCCGGGCATTACGGTGGGGCACGAAGACCTCCGTGCGGTGAGTTCCTAGACAGCTCCCACCACACCGGAGGTCTTCGCCATGTTCAAGACCACAGCCGTGTCAACAACGCTCGTGATCAATACACCTAGGCCGCTCCCCCGGTCGGCGCGCGCATCCCGCGAGGGGAGTCAGCCGACCTTGTCGGCCCGGCCCAGGCGGAGCGCGGAGACCAGGAAGAAGACCCCGCCCAGGAAGGCGTAGCCCGCCAGAGAACCCAAGGAGGCGTCCGGCTTTGCGGCCTGGGCGATGAACGAGGCTCCGGCGAGGGTGGAGATGGCGCCGCTGAGGATCATCGGCCACTGTCCGGCCATGCCGTGCCGGCGTCGCAGGGCGCCGACGATCAGCTGGACGGCTCCGGCGGTGACGGCCCAGGCGCCCCAGACGCGCAGGACCGCCGGGATGCCCGAGGTGGCCGCGGCGGCCAGACCGGCGGTGGTGAGGGTGCTGAGCGCGATGTTCGCGCAGAGACCCCGCACCGGGCCCTGGTTCGCCCTGGCGGACCTGAGGTCGACGACCGCGCACGCCACGTCGAACAGGGGATAGAGCACCAGCAGTGTCGCGCCGAGGGGACTCAGGGTGTGCGCGGTGGCGAACACCAGGGCGGCCCACACGGCGGCGAACGCGAAGCGGAGGAAGTACAGGCGGCGCAGTGCCGCGGTGTCGCTCTTGACGGGAACGGGGGCGGTGATGGACGAGGCCATGGGGTGCCCTTCCACAGGGAGTCGAAGAAGAGGGAGAACGTTCGGTCTCCCTCTTTCATCTAAGAGACCCCCATCCCCCCTGTCAAGACCGAACGTTCTCCCTCGCCGCCTGCTACCGTGGCCGCCATGAGCACCCGCACAGAAGGCAAGAGCACGTCCGAGGCGCGCGCGCGGCTGCTCGACACGGCGACCCGGATCTTCTACGCGGAGGGCATCCACTCCGTCGGCGTCGACCGGATCATCGCGGAGGCCCAGGTCACGCGCGCCACCCTGTACCGGCACTTCAAGGGCAAGGACGAGCTGATCCTCGCCTACCTCCAGCAGGCCGATCGCGGCATCCGGGGGCAGGTGGACGCCGTCCGGGCACAGGGCCTTCCGCCCGCCGAGACGGTCCGCGCCGTGGGCAGGTCCATCGCCGAGGGCATCCGGTCCCCCGGCTTCCGTGGCTGCGCCTTCCTGAACGCGGCGGCCGAGTACCCCGACCCGGCGCACCCCGTCCACCAGGCCGTACTGGCCCACCGGCAGTGGTTCCTGGAGACCGCCACGCAGCTCATGGACGACGCCGGCTGCTCCCCCGCCGAGGTGACCGGCCGCCACTTCGTCATGCTCCGCGACGGCGCGATGGCCGCCGGCTGCCTCTTCGACCCGGCGCTGATCTGCGCGACGTTCCTGGACGGAGTCGAGGGCATCCTGCGTACGGGCGCCTGAACTCCGCCTCCGTAGCGGCAGGGGCGGGTTCGCACACTCGGGGCGACTCTTCACTCGCCCCCTACCTGGGCGGCCATCCCCGCAGCGCCGCGTCTGCCATCGCCCGTAGCTCGTCCCGGCACACCCCACCGGCCGCCTGTACGGCGATGCCGTGGGCCAGCGTGGTGACGTACCGGGCCAGGAGCCCCGCGTCGGCTTCCGTCGACAGGTCGCCCTCCTCGACGGCCCGCTCGAACCGCTCCCGTATCCGCAGGTAGCCGTCGTTGCGCCAGCCGATCAGCAGTTCCCGGGCAGCACGGCCCGACTCGCCTGCGGCGAGCGCGCCCTGGACGCCCATGCAGCCCTGCGGTCCGGACGGAGCGGTGGTGGTCCGGATGACGCCCGCCAGGATCGCGGTGACGACACCGAGGGCGGTGGGCTGGTCCGCCTGGCGACGCCCGGCGCGGACGGTCCCACCGGGACGCTCCGGGACAAGAGCGGGGTGCTGCCTTGGTAAGCAGCGGCTTGAGAAGCGGTGCGTGCCCACCGAGGCGGGGGCCGTGGGTTCGAAGCGGAACTTCTCGTACCACGGTCACGGCGTGCCACGAGTTCGGCAGGCCGAGCCGCGCGGCCTCGGGCGTCTTGGCGCTCGGGCCCGTAAAAGCCGCCCCGCCGCATCCGCCGGGCCCTCACCGGGCGAAGTGTTCCGAGGACGTGAGAGGCGGGAGGCGTGGTGTGGAGATCCGGGGCGCGCGCGTTCTCGTCGCCGGGGCGACCGGTGACATCGGGTCGGCGCTGGCCGAGCGGCTGGCCGGGGTCGGAGCGGTGACCGCGCTCGCGGGGCGCGACCCGGCCCGGCTGGCCGGGGTGCGTGAGCGGTGCGGTCCCGGGCCCTCGCGGATTTTCGACGCCTGGGACCTCGACGGCGCCGAGGGCACGGCGGCCTGGGCGGCGCGGGAACTGGGCGGGCTCGACGCCGTGGTCGTCTGTGTGGGGGTGGCCGCGTTCGGGCCGGTCGGTGAGATCGGCGAGGCGGTCGCGGAACACGTGATGGCGGTGAACGCGCTCGCGCCGATGGCGATCCTGCGTTCCGCGTCCGCCCATGTGTCCCCGGGCGGCCTGCTCGCCGCCGTCACGGGGACCGTCGCCCGCTCGGCCCCGGCCGGCATGGCGGACTACGCGGCGGCCAAGGCCGCGCTGGCCACCTGGCTGACGGCGACCCGGCGGGAGTTGCGGCGAGCGGGGGTGGGGGTGCTGGAGGTCTGCCTGCCGCACGTCGAGTCCGGGTTCGCCGGGCGCGCGGTGACCGGCACCGCTCCGCCGCTGCCGCCGGGCATCACGGTGGCCGAGGCGGTCGACGTCATCGTGGAGGGGATGCGCATGGACGCGCGGGTCGTGGACAGCGCCCGGTCGAAGCGGGGTACGACGTGACGGCAGGTACGTCAGCTCACGTGGAGGACGTCACGCCCCTGTCCCCACGCCCCCTGTCGCGCGTCCTGTTCCGGCAATGGTGGCGTGAACTGGTCTTCCTGCACTGGGAAGTCGACCCCGACGAGGTGGCACGGCTGCTGCCTCCGGGGACGTGTCCCGACCTCCACGAGGGCCGCGCCTACGTCGGCCTCGTCTTCTTCCGCATGGACCACCTGGCCTTCGGACGGGGGCCCGCCGTCTCCTACCTGGGCAGCTTCGGCGAGGTGAATGTCCGCCTGTACAGCAGGGACGCCCTCGGGCGGCGCGGAGTGGTGTTCCGCTCCCTGGACTGCGACCGCCTGCTGCCCGTCCTGACGGCCCGGACGGCGTTCGGCCTGCCCTACCGCTGGGCCCGCATCCACACCCGCCGCACCGCCACCGGAATCTCCTACGCCAGCCTCCGGCGCGACGGTTCGGGAGCGGGCGCCCGCGTCCGGGCCGACATCTCCCCCGAGCCGTACGAGGCGACCACCCTGGAGCACTTCCTCACCTGCCGCTGGGGCCTGCACGCCCAACTCCGCGGCCGCACCTATTACTTGCCGAACACCCACCCCCGGTGGACGTTCACCCACTGCGACCTGACCTCGTACGACGAGTCAGCCATCGCGGCAGCCGGACTCCCCGCCCCGGCCGACGCCCCCGTCAGCGTCCTCCACGCCCCCGGCGTCCCCGTCCGCTTCGGCCCGCCTCAGCGGCTGCCCTAGGGACCCGAACCACCCGGACTTCGAGCTGCCCTCACGCACAGCATTGACGTGAGCACGACCCACCACTACGTTGCCACAGCGCTGAGACAACGTTGTCAGGTCGTCAGGGAGGTTCCCGGTCCCGCCTCGCTCTCCCCCACTTCTTCAGGAGGCACAGAACGATGTCCTGGATCTCGTCAGGCAGACCCCGGCGTGCGCGCCGGGGGTATGCGGTGGCTGCCGCCGTGGCAGGGGCCGCGCTGGTCGGTGCGTACGCGCTGCCCGCTTCCGCGGCGCCCGCGCGGGTCGCCGCTCTCGTGGCTCATCCGGCCGATCTGGTCAACCCGTTCATCGGTACGTCCAACGACGCCAATGACTTCCCCGGCGCGGACGTGCCGTTCGGCATGGTGCAGTGGAGTCCGGACACCTCGTCGCGGCCGCCGGGCGGGGGGTACGAGTACAAGGACGCCTCGATCACCGGGTTCAGCCTCACGCACATCGCCGGGCCCGGCTGCGGGGCGGCGGGGGACGTGCCGGTGCTGCCGACGGTCGGCGCGGTCAACAACTCGGCCACCGACTCCTTCTCGCACGCCAACGAGTCCGCCACGGCCGGGTCGTACAAGGTCGCGCTGGACAACAAGGTGACCACCGAGCTGGCCACCACCGCGCGGAGCGGGATGGCGCGGTTCACCTTCCCGGCCACCACTCAGGCGAACCTGCTGTTCAAGCTGAACAGCAGTCAGAACGGCGGGAGTTCGACCCAGTTCAACGTGGTGTCCAGCACCGAGGTCAGCGGCCAGGTCACGAGCGGCCGGTTCTGCGGGGCGGGCAACAGCTACACCGTGTACTTCGACATGGTCTTCGACCGGCCGTTCGCCACCAGCGGCAGCTCACTCGCGCCGGAGAAGCCCGCGCCGAGCGCGAAGCGGGCCGGGAAGAACGCGGCGGACAAGCCCAACCACCCGCGCCTGCACGGCACCGCGCCCAAGTCCGTCAAGGGCGGTGCGACTCCGAAGGCCGCCGCGTCCAACGCCCACGTCACCTTCGACACCAGCTCCAGTCAGACCGTCCAGGCCAAGGTGGGCGTCTCCTACGTGTCGATCGCCAACGCGAGCGCCAACCGGGTCGCAGAGAACCCCAACTGGAACTTCGACGCGATCCGCACCTCGGCGCACGACGCCTGGGACTCGGCGCTGGGCAAGGTGCTGATCGGTGGCGGCACCTCGGACCAGCAGAAGATCTTCTACACCGCGCTCTACCACTCGCTGCTGCACCCGAACGTCATCAGCGACACCAACGGCCAGTACTTCGGCTTCGACGGCAGGACGCACACGGTGGACTCCGGTCACAGGGCCGCGTACGCCAACTACTCGGGCTGGGACATCTACCGTTCCCAGGCCCAGCTGGAGGCGCTGGTCAGTCCCCAAGTGGCTTCCGACACCGCCCAGTCGATGCTCGACGACTACCAGCAGACCGGGATCTTCCCCAAGTGGTCGGAGAACAACGGCGAGTCCTACGTCATGGTCGGTGACCCGGCCGCCGCGATCATCGCCGACTACTACGCCTTCGGCGCACGGAACTTCGACACCTCGGCGGCGCTCGCGGGGCTGCTGAAGCAGGCGAGCACCGCCAACAACGACCGCCCCGGCCTCAGTTACCTCGACAACCCCGGCTACGAGCCGCACGACGGCAGCTACGGCTGCTGCAACTTCTACGGCCCCGTGGCCACCACCCTGGAATACAACACCGCCGACTTCGCCCTCTCCGCCTTCGCCGGCGCCCTGGGTGACAGCGGGAGCCAGAAGACGTACGCGCACCGGGCGCAGGACTGGCGTAACGTGCTCAACCCGGCCTCCGGCTTCGTCCAGCCGCGCAACCTCGACGGCAGCTGGACCGGCGGGTTCGACCCGACCAGCGGGACGGACATGGTGGAGGCCGACTCCTGGATCTACACCGGCATGGTGCCGTTCAACGTGGCCGGGCTCGCCACCGCCAAGGGCGGCAACAAGGTGATGGGCGACTACCTGGACACCGTGCTGCGCAGCTACACCGGTGCCAACGGCTACGCCTGGGTGGGCAACGAGCCGAGCATCGAACTCCCCTGGGAGTACGACTACATCGGCATGCCGTACAAGACCCAGGCGACGGTGCGCGCGGTCCAGGACCAGATCTGGTCCAACTCCCCGGCGGGGCTGGCCGACGGCAACGACGACCTGGGCGCGATGAGTGCCTGGTACGTATGGTCGGCGCTCGGCATGTTCCCGATGACGCCGGGCACGGCCGATCTCGCCCTCGGTTCCCCGCTGTTCCCGCAGGCGCAGGTCACGCTGCCCTCGGGCAAGACGCTGACCGTCAACGGCACCGGCGCGGCGGACAACGCCCCCTACGTCCAGTCCGCGACCTTCAACGGCTCGGCGTGGAACAACGCCTACGCCCCGACGTCCGCGCTCACCTCGGGAGGCACCCTCGGCTTCACCCTGGGCACCACCGCCAACACCGGCTGGGCGAGCGGGACTTCGGCCGCACCCCCGTCGTACCCCGATGACACCTCCGCCCCGGCCAAGCCCCGGGTGGGTCCGGTGAAGGCCGGTGTCAGCTCCTCGCTCTGCGTGGACGACGCCAACTCCGGTACGGCGGACCACACCGCGATCCAGCTCTGGACCTGCAACGGCACATACGCCCAGGACTGGACGGTCGCCTCGGACGGCACCCTGCGCACCCTCGGCAAGTGCCTCGACGTGACGAACAGCGGAACGGTCAACGGCACCCTCGTCCAGCTGTACGCCTGCAACGGCACCGGGGCGCAGAAGTGGACGGCCGGCTCGGACGGCTCCCTGAAGAACGCCAACTCCGGTCTGTGCCTGGACGATCCCAACTCCGCCACGGCGGAGGGCACCCGCCTGCAGATCTACACCTGCAACGGTTCGGCGGCCCAGAAGTGGACCCTTCCGGCGGCCTGAGCACCCGAGTGCGGCCCCGTCCCTCCCCGGGCGGGGCCGCACTCGGCCGTACGCAGGCCGGAGATGAGGCGGCGGACCGTAGTCCGGACTCAGGCGCCACCCGGCGAGCCCGAACGGGGCGATTCGCGGGCGGACTGGGAGCGGGTGTTGGGCGGGGTACGGGTGTCCCGGAAGCGCAGGTCGCGGCCGTGTCGCCGGAAGAGGTCGCTGACGAACTCGTCGAGCGCCAGGATCTCGTCCTCGCGCGAGTGGATGTCGGCGAGAGCGGCGCGCTGCTGCTGGTCGATCACGCGCTGTCCGTCGCGCCAGGACTGGTCCGCCGGCGCCTCGGGCAGGTTGTCGAACTCGTCCTGGGTGCGGACCTGGAAGGTCTCCACCGGCTCAAGGATCATTGGGCCGCCCGAGGGGTCCTCGCGGGAGCGGTAGACGACGAAGGACAGCCCGTCCACACGGTTGTCGGCGATGGAGGCGCGCAGCTCGGGCCACTCCAGGGTGCTGAGCACGCTGGATCCCACGGTGCCGTCCAGGGCGTGGGCGGTGACGGTGCCGGTGAGGGCCTGGACGTAGGTCGTCGACAGGCGCTTCCACAGCGCGGCCAGGGCGTCGGAGGCGCTCCAGGTCGGCAGGCCGAAAAGGAGGCCGTCGAAGATACGGCCCTGTATGGACGCCTCCAGCACCACACCGTGGCCTACGCTCGCGTCCTCGGTGGGGATGGCCGAGTTCATCTTGGACCAGAGATGCCCGTGCTCCGTCGAGCCGGCCGCGACCCGGTCGAGCGCCCCCTGGAACCCCTCCTTGCCCTGCTGCCGGACGAACCAGGAGTACTGGACACGGTGGCCCTGGACCCGGGGATCGTGGAAGCCGTCGATGATCCGGTCGATGGCGGCTCCGTCCACGGCGGTGGGCTGCCCGGCCTTCATGTCGGCCTCGATGTTGTCGAGGAAGGCGTCGAGTCCGGACATGAAGCCGGGCACGTTCTTCAGCACCTCGATCCGGCCGACGCGCCCCAGGAGTTCCGCCTTGTCCTGAGCGAACTTGATCTTCCGCCGGTCGACGGCGGTCATCGAGTGCGCGGACTCCTGGGAGCTCTCGGTCTCCTGCGAGTCCCCGGACTTCTGCGAGGTCCGCGAGGGCGGCCGCGAGGGCTCGGGCGACCGCTGCACGACGTCCTCGGTGCGGGCGTCCGCGACCAGCCGGGACACCGCCGCGTTGCCGGCCGACCGCTGGAGGGCCAGAAGCGGAGGCGCCGGCGCGCCGGCCCGCCGTGCCCGATCGGTGTCGGGACCGTGCGTTCCGTCCCGGTCCGTCCCGTGCCTGTGTGTGCGCAACGCGCTCCCTCACCCACTCGAGCGGAACCGGATCATGACGGTGAACCGGCTCCGATGCTTAGAGGAGATCAAGCCAAGTTTGATTCGTAGTCAATGGCGCCTACTTGCGGTTACCGAGAGAAATTCAGGCAAGACACCCGAACATAGTCGAGCAATTCGGTCACATGATCGACAGAACCGGGAGTCCTTTTTCCGGACTCCCGGCCCTGTCACGGCTTTGCATCACGGCGCGTCTCGCAGAGCATGGGCGTGACGCCCAAGTCACCTGATGTCGCTGAGCACTCCGCTGACGTTGAGCACCTCATGGCACTCCTGGGCCCGCCTGCCGGTGGCGGGGGTACCGGGCTTGGCACAGGTGACCTGGGCGGTGACCGTGTCGTTCGCGGAGATCCTGATGGGGGTGACCCAGTGATAGTCCTGGTTGCGGAAGGTCTCCAGCGCGATCGTCGTGATCTTCCGGTCACCGAAGTTGATGGTCAGCACCCCCTCGTCGCCCTGGAAGTTGGCCACGACGATGTCGGTGACCTGGAACACCTTGTCCGCGGGGACCGTGTAGGTGCCGGTCTTCTCCGCGCCGCCGCCCGTCTGCACGTCGATGGTGGCCGAGCTCTGGCCGCCGCCGGCTCCGCCGCCACCCCCGCCGTTGCCGGTTCCGGTCCCGGTGCCCGTACCGTCGCCGCCGCCCGTGCCCGGCTGACTGCCCGCGCCACCACCGCCGGTGCCGGGCCGCCCGCCGTCGGCTCCCGTGCCCTGGCCGGCCTGCTCGCTGCCGCCGGGGGTGGGCCGCTGCTGGACGACCTCGTCGGCCGCCTCCTTGGCCGCGCTGCGCACGGCGGGGCGCACCAGGGTGAACCAGGCGAGGAGCAGGGCGATCAGCGCGGCGAGCACCGCGAGCAGCCACTTGGGGAAGACGGGGATCTGGACGAACTCGGCGTCCAGCGAGGTACGGATGGTGTCCGGGCGCTCCGGCAGCGTCGCGTCCGGTGCCGCCGTCTCGGCGACGGTGACCGTGAACGGCCAGATGACCGGGGCGCCGAACCACACCGGCTTGCCGATACGGGCCCGCAGACCCACTTCCGCCGACTCGCCGGGCTCCAGCGCCTGTTCGGCGGGCTTGAGGGTGAAGCGGAGTTCCTCGCCGGGCTGGGCGGGCGTGAAGCCCAGCGTCACCGGGGAGTTGCCCTCGTTGCGCAGCGCGAGCCGGTAGCGGCCGCGCAGCCAGCCACGGCGGCGGCGCGGGGCGATCTCGGCGCGCAGCTCCCGGAACTCCTCGACCCGCACGGTCGATTCGGGCACCCGCACGGCCTCGGGGTGCTCGGTGGGCAGCACGCGTACGGCGAGCGGCACCTCACCGGCGCGGACCTCGGGGGACCTCGGGGGTTCGAGCCGGATGGTCACCGTCTCGGAGGTGCCCGGGTAGAGAGATACGCGCGCGGGCTCCACCGTGGCCCAGGCAGCGCAGTCGCCGACCACCTCGAGGCCGTATGCCTCGACGATGTCGCTGTCGTTGCGGACGGTCAGGGTGGTGGTGGCGAGCCCGCCGGGCGTCACCGACACCGCGGGGATGTCGGAACCGGGCGCGCCGGGGCTGGGGGTGGATGCTGGAGACGTCACCCGGCGACCGTATGACGCGGTCCCTTCCTTTCGGAGAGACGCGAGGGCAAGCCCGCGGGCAGCGCTCGTGCCCCGGACAGCACTCACCGACTCCCTTTTGGCTTACGCCAGTTGACCGAAGACCCGGCGCGGGCCGACTTCCGCCGCCCGGTCCCGCACGTTGCTCCACCGGCCCGTCGCACCACCCCCACACGTTCGATGGAATCAGGACTCATGACCACGAGCTGCCCCCAGGCCAACCATCCCGCTCCCGCCGCCCACACGGCCCCCTGGACCACCTCCGCCAGGCGGCCCGAACGGGTCTCTGTCACCGTCTATGCCCCCGATCCCGTGCTCTACGTCGGCATCGTGCACCAGTTGCGCCAGCGCCCCGAGATCGAGTTCGTGGAGGCCGGGGCCGCGGACAGCGCCCAGGTCTCCCTGATCACCGTCGACACGGTGGATGACGAGACATCGGCCCTGCTCAACCGGCTGCGCCACAACTCCGCGACCCGGACCGGCCTGGTCGTCGGCACCTTCGAGTCGGGTGACGCTCTCCAGCGCGCCATAGACAACGGGGTGGCGGCGGTGCTCCGCCGTGCCGAGGCCGACCAGGACCGGTTGCTGCGTCTGGTCCTCGCCATAGCCAACGGCGAGGGCATGCTGCCCGGCGATCTGCTCGCCAAACTCCTCACCCACGTCGGCAGCATGCAGCGTTCCTCCCCGCTGGACCCGAGGGCGGCCTCGCTGTCCACGCTGGCGCCCCGGGAGACGGAGATGCTGCGGCTGGTGGCGGAGGGCCTGGACACCGGGGAGATCGCCCGGAAGACCTCGTACTCCGAGCGGACCGTGAAGAACGTGCTGCACGAGGTGATCACCCGGCTGCAGCTCCGCAACCGGGCCCACGCGGTCGGCTACGCGCTGCGCAACGGCCTGATCTGAGAGGTGTACCGACCAGGGGCTGTCGGCACACTGCCCGAAAGCCCCTCCGCCGCTTCCCCCGGGAGCGTCCCGCCGGCCCTGCCGCACCAGGGACGGCGACGCCCAGGATGGCGGACGGTTGTGCGAAAGCTGGAGTGCGGACGGTGAGGTGGGCCCGTGACGGGCACGGACAAGGCCGGCGGGTGGCGGTACCCGCTGGAGCGGATCGGCCTGGCGTTGTTGCTGCTGGTCCCCCTGTTGGCGGTGACGGCGGCCGCCGGTCCCGGTACGGCGAAGGCCCGCCCCCGAGCCGGTGACGAGGGGGTCACCCGGATCGCCTACGCCGGCACCCGGCACCGCAGCCTGGGCCGGGTGGAGACGACGAAGTCCAGCGCCCCGCTGTTCGGCGTTGGCGCGACCCACTACGACGTGGAACCCTCGGCGCTGGGCGACCAGTTGGTCTTCGCCAGCCGCCGGGACGAGCGGAACCCGCAGGTCTACCTCCGGGCCGCCGACGGCTCCGTGGCCAAGCTGACCAGCGGCCGGGACGCGGCACACCCGCGGCTGACGCCCGACGGCCGCTCGGTCGTCTTCGACTCGGCCGAGCCCGGCGGTCCCGGCGGCGCCACCCAGCGCGACCTGTGGCTGGTGCGCACCGACGGCACGGGCCTGACCCGGCTGACGAACACCCCGGCCGACGAGGAGTGCCCGACGGTGTCGCCGGACGGGCAGCGCCTGGCGTACTCCAGTGACGCCGATCCCCTGGTGGGGCAGCAGGTCTACGTCCGCCCGCTCGGCGGCGGCACCGTGAACCGGGTCACCGATCCGGCGAACGGCACGGCGAGCGAACCGGCGTGGAACCCGCTGGACAACGCCGAGAAGCGGGACATCATCGCCTACACGGCGACCACCGCAGACGGCCCCAAGCTCCGCTATGTCTACGCGAGTTCGGGTGACGGCGGCCCGCTGCTGGGCGCCACGGAGGCAGGCTGGCGTACCCATGGGGCAGCCTGGTTGCCCGACGGGAACCAGTTGCTGTTCCTCAGCCCGGACCGCGACTGCACCTGCGAGGGCGACTTCGACCACGTCTTCAAGACGGTCGTGCACTCCGACAACGACGCCAACCGGTCGCTCGTCCTGACCGAGGACCGCGAGGTCGGCACGGTCACCTGGCTCGGACCGGTGGACGGCGGCGGGACCGTGGTGGACCGCACCACCGCCGCCGGACCGCACGTGGTGACCCTCCAGGACGCCCGCGCGGACGGTTCCGACCCCCGTGACCTGGGTCTGACGATCCTGAACGAGGACCCGGCGGCCGACACCAACACGGACCCGACGAAGGACCCGCTGTTCCAGCCCGCCGCCGGGTCCGACCCGTGGACGGAGCGGCAGAACTACACCCCGGACGGGCGGCAGATCGTGCTGACCCGGTTCGAGGACTCCGACGCCGGACGCATCGAGCGGATCTGGCTCGCCGACGCCGACGGCTCCAACGCGCGGCCGCTGCCGCTGGCCGGACGCGGCGCGAAGGACTGGGACACCGACCCGACCTTCTCCCCGGACGGCAGGTACATCGCCTTCCGGCGCACTTCGCCCGGCGGCACCGGCGACGCGGCCGGTCCCAGCAAGGTGCTCATCGCCGACGTGGCGACCGGCGCGCTGCGGGGCACGATCACTCCGCCGGCCGGACAGGCGCAGGGCACCGACGCCCAGCCGACCTGGTCCTCGGACGGCACCCAGCTCGCCTTCACCCGTACGCAGGTGATCAACGGGGGCAACGGCAACAAGCACATCTGGACCGTCCCGGTCGACCGTCTCGGCCAGCAGCGCGACCTCAGCGCCGCCGACTGCCCCGGCGCCTGTGACGTCATCGACGACAGCCCGGCCTTCTCGCCGGACGGGCAGACCATCGCCTTCAACCGCAAGGCCGGTGGCGGCCGGGTGGACCAGCAGGGCGGGCTCCTGCTGACCTCGGTGTCGGGCGACGACTGCCGGGTGCTGCTGCCCGCCGCCGGGCGCGGCCTGCCGGGCGCCTGCGGCCGGGAGCTGCCGAACGCGGGCACGGGTCCGTTCCAGCCGCGTGACGCCGCCTGGACCGCGGACGGCACCGCTCTGGTGTTCAGCTCGCGTGCCCAGCTCGCGGCGAACAGCCCGGAGAAGCTGAGCCGGGTGGACGTCGAGTCGGGCGCCCTGACCCCGCTCACCACCGGGCTGGCGGGCCGTCAGAAGGAGCCCTCGGTACAGCAGTCCGTGGACCTGGCCGTACAGGCACCGGACACCTCGGGGCAGGTGATCGTCGGCCGTACCGGCACCGTCCGGGTCGACGTCGTGAACCAGGGCCCCGCGGCCTCTCCCGGTACCCGCTTCACCGTGGCGCCGCCCCTCGGTGCGACCGTCACCGGGCTGACCGCGCCCGGCCGGAACTGCGACGTGCGCGGCCTCACCTGCGACCTCGGCGTGGTGCCGCCCGGCGCCACCGTCCCGGTGACCGTCACCTTCACCGGGGTCACGCCCGGCGACCAGCCCGTGGACTGGTCGGTGACCGGCGCGGTGATCGACCCCGACCCGAGCGACAACACCGACCGCACGGTGGTCCCGGTGCGCGAGGCGCCCGCCCCGCCCGACCCGACGCCGAGCCCTGCCCCGCCCACTCCGACCCCGCCCACGACGCCTCCGGTGCCGCCCGCGCCCCCGGCGCCGCCGGTCCCGGAACCCCCGGCGCCGAAGGCCGGTCCGGGTGTGACGGTCACCGCCAACCCGAACCCCGGCTATGTCGGCGGCCGCGTGGTCGTCACGTACACCGTCCGCAACGGCCGCAACGCGCTGGCCACCGGGCTCCGGCTGCGCATCGGGCTGCCGGCGGACATCCCGAACAACGGGCGCCCGCCCGGCTGTGACGCCAACTGGCTCTGCGCGCTGCCCGATCTGGCGCCCGGTGCCCGCAGCACCCTTCAGGTCGTGCTCACCCCGAAGAAGGCGCTGACCGCCGAGGTCACCGGCACCCTGACCACCACCGGTACGGACGCCGACCGAGGCGACAACTCCGCCCGGCAGCGGCTGCGTGTCCTCCAGCCCAAGATCGTCGCCGTGCCGCCGATCGGCAAGCCCGGCTTCGTGACCTCGGTGCGCGGCAAGGACTTCCCGCCGGGCGTGCCGGTCCGGTTCCGCTGGAAGCCCGGCATCACCGCGGCCGCCGCGCCGACGGTGCCGCTGCCGGACGGCACGTTCATCGGGCAGCTCCTGATCCTCGCCAAGGACCAGACGGGCCCGCGCACCATCACCGCGAGCGGCCCCGGCTTCTCCCCGGTGAAGACGGACTTCCTGGTCGTCAACGGCAGTGTGCAGCCGCCGGACGAGGTGACCCGCCGGTGATCCACGAGGTCGACGAGGCCCTGCGGGGCCTGCTGGAGGAGTCCGGGCTGGCAGCGTCGGGCGTCGAGGTGGTCTTCGACGCGCCGACCAGCGACTGGGCGGCCCGGCGCAGCGCGCCCACGGTGTGCGCGTTCCTGTACGACATCCGCGAGGACAACTCCCGGCGCAACAGCAGCGCGGGCGAGATCTACGACGAGGACGGCTTCGTCGTCGCCCGTCGCTCGCCCGCCCGGTGGTTCGAGCTGACGTACCTCGTCACCGCGTGGGCGAGCCGCCCGCAGGACGAGCACCGGCTGCTGTCCCAGGTGCTGTCCACCCTGGTGTCCACGGACACCCTGGCCCCGCGTCTGCTGACCGGTTCGCTCGCCGAACTGGGCCTGATCGTGGGCCTGGACGCGGGCGGCACCGGTCTGGACGCCCCGGCCGCGTCCGACGTGTGGTCCGCGCTGGGCGGCGAGCTGAAGCCGTCACTCGGGTTGCGGGTACGCGCCCCGCTGGCCGGCATCGAGCGGGTGGCCGCGCCCCCGGTCACCGAGGGCCTGGTCGTACGGTCGGTGCCCCACTCCCTGCCGGACGAGCCGGAGTCCACCCGCCGGCTGCGGTACGCGGAGATCGACGATCCAGGCGGCGAGGGCTTCGGCGGGTCCCGGGAGCGGCGGCCCGCGCCGGCCCGGCGCCGCAGGAGGGGTGACCGCCAGCCATGACGCACCCCGTGGAACCGGAGCTGTGGCACCGGCTGCACACCGTGGAGGAACGGGTACGCAAGGCGGTCGCCGCACGGCGGGCCGTCGACCCCGACCCGGACGACCCCTACCGGGGCCAGTACCTCACCCCCGAGGCCGCCCAGCGCGTCCTCGACACCCGCGCCGAGCCGTCGGCCACCGAGCCCGAACGGTCGGCGGAGGACACCCCCCTCGGCCGCCTGGCCCGGGACTTCGGTCTCAGCCCGCTCGACCTGGACCTGCTGCTGGTCGCCCTGGCGCCGGACCTGGACGCCCGCTTCGAGCAGCTCTACGGCTATCTGAACGACGACCTCACCCGGCGCCGGCCCACGGTCGGGCTGGCCCTCGAACTGTGCGGGCACACCGGGCTCTCCCCGGCCCGCTTCCGCCTCTCCCCCGGCGCCCCGCTCCTCGCGGGCGGGCTGCTGGAGGTCCACGAGCCGGAACGGCCGCCGCTGTCCCGGGTGCTGACGGTGCCCGACCGGGTGACCGCGCATCTGCTGGGCGACACCGCGCCGGACGCCCGCCTGGGTTCGGTGCTCGGGGAGCAGACGGCCGACCCGGCCGCCGACCCCGCGCTGGTCCGGCGGGCCGCGGCCGGGGTCCGGAGCGGCACCGGGCATGTGCACCTGCGGGCAGTCGGCGGTGCCCCCGAGGGCCTGGCGGACGCGGCGCTGCGCGAAGCGGGCCGCGTCCCGCTGGTGCTGGACGCGGTTGCCCTGGCCCGGCACGCCCGTGACCTGCCCTCACTCGCCGCGGCCGCCGCCCGCGAGGCCCGGCTGACCGGCGCCGGGGTGGTGCTCGGCCCGCTGGACGACCTCCCCGACAAGCCCGCCGAGCGGACCCATGTGCTGCGCACGGTGTGCGCGGCGCTGTCCGGCATCCCGCTGTTCACCTACGGCGCGCAGGTCTGGGACCCGGGGTGGGCCGTCCGTACCCCGGTGTCCTTCACGGTGGGCACCTCCTCGCCCGAACAGCAGGCCGTGCGCTGGCGGTTCGCGCTGGAGGCGTCCGGTGCCCCGGACGGCTCGGGCAGCGAGGACCTGGCGCGTGCCGTGGCCGCGCACCGGCTCGACTCGGGCCAGCTCCGGCGCGCGGCCGACGCCGCCGTGCGCACCGCCGGACTCGCCGGTCGCCCGGTGGACGCCGAGGACGTACGGGCCGCCGTACGGGCGCAGAACGGCGCGGGGCTGGCCCGGCTGGCGCGGCGGGTGGAGCCCGCGGTCGGCTGGGACGACCTGGTGCTGCCGCCGAGGACCCTGCGGGGTCTGCGCGAGCTCGCGGTGCGCGCCCGTCACCGCGATCAGGTGCTCGGCCGGTGGGGCATGCGGCCGGGCGGCGGCCGGGGGCGTGGCGTGATCGCGCTGTTCGCCGGGGAGTCCGGCACCGGCAAGACGATGTCCGCCGAGGTGGTCGCCACCGACCTCGGCATGGATCTGTACGTGGTCGACCTGTCGACCGTGGTGGACAAGTACATCGGCGAGACCGAGAAGAACCTGGAGCGGATCTTCACCGAGGCGTCGGCGGTCAACGCGGTGCTGCTGTTCGACGAGGCCGACGCCATCTTCGGCAAGCGCTCCGAGGTGAAGGACGCCCGCGACCGGCACGCCAACATCGAGTCGGCGTACCTGCTCCAGCGGATGGAGTCCTTCGACGGCATCGCCGTGCTGACCACCAACCTCCGGGCCAACCTGGACGAGGCGTTCACCCGGCGGCTCGACGTGGTGGCCGACTTCCCGATGCCGGACGCGGCGCAGCGGCTCGCGCTGTGGGAGCGGTGCCTGGGTGACCGGCTGCCGCGCGCGGAAGACGTCGACCTGAAGTTCTGCGCCGACCGGTTCGAGCTGGCGGGCGGCTCGATCCGGTCGTGTGCGGTGACGGCCGCGTATCTCGCGGCGGATTCGGGGAATGAGCTGACCATGCGGCAGGTCGTGCAGTCGGTCGCGCAGGAGTACCGCAAGCTCGGCCGGCTGGTGCTGGCCGCCGAGTTCGGTCCCTGGCTCGCGCAGGTCACGGCCGCCTGACCCTGCACGCGCGGTGCGGCCCGTCCGCCCGCGCGGGCAGTCGCGCTGCCCCCGGGCAGGGCCCGATGTCCCCTGCCCCGGGGCACGGCCTGAGGAAAGGGTGGAGGAGACCCGGACCGCAGGACCCGTGAAGGAGCGAGCATGCCGACGTACCTCACCCCAGGTGTTTACGTGGAGGAGGTGCAGTCCGGTGCTCGCCCGATCGAGGGTGTGGGCACCGCGGTCGCCGCGTTCGTCGGCTTCGCCGAGGACGGCCCGTTCCACGAGCCCACGCTGGTGACGAGCTGGGACCAGTACACCCGTACCTTCGGCGGTTTCGTGCAGGGCGCGTACCTGCCGCACTCCGTCTACGGCTACTTCGCCAACGGCGGCGGCTCCGCCTACGTGGTGCGCGTCGGCGGTTCCGCCGACGACTCCTCCGCCCCGGCCGGCAACGGTGACGGCGCGCGGCGCGAGCAGGCGGCGCTCGCCGTCGAGGTGGGCGGCTTCCAGATCGCGGCCAAGCCCGGTGTGAGCGGCGTGTCCATCGAGATCGCCGACCCGGAGGGCGAGAACCCGCCGGAGGACCGCTTCCGCGTCCTGGTCCGCCAGGGCGAGCAGGTGGCCGAGACCTACGACGCCTCGACCCGCCGGAACGTCAAGGGCTACCTGCCCACCCAGGCCCGCAACTCGAAGCTGATCGAGGTCACCGAGCAGCGCGGCGGGAACCAGACGCGGCCGGCGGCGCAGACCATCGCCGTCCCGGACGCCCCGGCCTCCCCCGCGCCCGCCACCTCCGGCCAGGTGGCCCGGCTGGACCCGGCCGAGTACGTCGGTGACGCCGACGCGCGCACCGGCTTCGCCGGCCTGGAGAGCGTGGACGAGATCACCATGGTCGCCGTCCCCGACCTGATGAGCGCCTACCAGCGCGGCGACATCGACGCCGAGGGCCTGCGCACGGTGCAGCTCGCCGTCATCTCGCACTGCGAGCAGATGGGCGACCGCGTCGCCGTCCTGGACGCCCCTCCCGGCCTCTCCGCGCAGCAGGTCCGCAACTGGCGCAACGACGAGGCGGGTTACGACTCCCGCTACGCCACCCTGTACTACCCCTGGGTCCGGGTGCTGGACCCGGCCGCCGGCCGCAACATCACCGTCCCGCCCAGCGGGCACGTGGCCGGCCTGTGGGCCCGCAGCGACACCGAGCGCGGGGTGCACAAGGCGCCCGCGAACGAGGTGATCCGCGGCGCGGTCGACCTGGAGCTGCGGCTGAGCAAGGGCGAGCAGGACCTGCTCAACCCGATCGGCGTGAACTGCATCCGTACCTTCCCCGGCCGGGGTGTGCGGGTCTGGGGTGCGCGCACCCTCTCCTCCGACCCGGCGTGGCGCTACCTGAACGTGCGCCGGCTGTTCAACTACCTGGAGGAGTCGATCCTGCTCGGCACCCAGTGGGTGGTGTTCGAGCCGAACGACGACCGGCTCTGGTCGAGCATCCGGCGCAACGTCAGCGCCTTCCTCACCGAGGAGTGGCGCCGGGGCGCGCTGTTCGGGCGGACGGCCGCCGAGGCGTTCTACGTCAAGTGCGACCGGGACAACAACCCGCAGGAGTCCATCGACCAGGGACGCGTGGTCTGCGAGATCGGTGTCTCGCCGGTCAAGCCCGCCGAGTTCGTGGTGTTCCGGCTGGCGCAGTTCTCCGACAGCACCAGCCTCGTCGACGAGTGACGTCCGTCGCTTCCGGCACTTATCCACCCAGAAAGGTGACAGACAGTCATGGCTGAGGGCGATGCTCTTTCCACCCATATCTTCGGCGTCCAGCTCGGCGGCTACCTGGTCGAATCCATCCAGGAGATCAGCGGCCTGAGCGTCGAGGAGGAGGTCGTCGAGGTCCGGCAGGTCAGCTCCGAGGGCAAGCAGATCATCCGCAAGCAGCCGGGCGCCCGCCAGGCCGGCGAGATCACGATCACCCGCGGACTCGACCAGAGCAGCGAGTTCACCTCCTGGATCAAGGAGACGCTGAACAACGGCGCGGTGGACACGGCGCGGCAGAACCTCACCATCGAGATCAAGGACTCCACCGGTGAGACCGTGCGGCGCATCCAGCTGATGCAGGGCTGGGCGTCCAAGTGGGAGGGCCCGTCCCTCAAGGCGGGCGAGTCGTCGGCCGCCACCGAGTCCGTGACCATCGTGTTCGAGGAGATCATCGTCGAATGAGGCGCCGTACGGTGACCGCGGGCAACCTGGACGAGATCCTCCAGGCGACGGCTCCCGCGAAGGACGAGGCGGAGGCGGTGTCCAAGCCGTTCACGCCCGCGGCGCCGCCGCGCCAGGAACCCGCGCTGCGCACGGAGTTCGAGTTCGAGCTGCCGCGCGGGTACGTCGACGAGGCGGGCACCGTGCACCGGCACGGCTCGATGCGCCTGGCCACGGCCCGCGACGAGCTGCGCCCGCAGATCGACCTGCGGGTCAAAGAGAATCCCGCGTACCTCAGTGTCGTGCTGCTCAGCCAGGTGATCACCCGGATCGGCACGGTCACCGATGTGCACGCGGGGATCGTGGAGCGGATGTACGCGACCGATGTCGCGTTCCTCCAGGACTTCTACCGGCGCGTCAACAGCGAGGGCCACACACGTGCGGCGGTCACCTGCCCGCACTGCGAGGGCGGCTTCGAGGTCGACCTCTCGGGTGGGCGCCTGGGGGAATCGTGACGTACGCGCCTTCCCGGCTGCGGGAGGAGATCGCGTACGTCGCCTACCACTTCCACTGGAGCCGTGAGGAGATCCTCGACCTCACCCATGCCGAGCGCCGGGAGTGGGTCACCGAGATCGCCCGCATCAACACCCGCGTGAACGAAGGCGGTTGACCGCATGGGATGGCGAGACAGGGTGCGTCGGCCCCGGCCGCCCGCCGCCGGGAACGCCGGCGACGCCGGCTCCGCGCCAGTGGAGCGGGCGTCCGCCGGCGTCGGCGTGCCCGAGAGCTGGGACGGCGGCTGGCGTGCCGCCGCCACGCCCGAACTGACGGTGTCCCGGGCCCCGTTGGCGGTCAGTGACGGCCTCGGTTTCCGTGCGGGGCTGGCGGCCTGGCGCGACCCGTCCTTCGACACCGGGCTCGCGCACGGGGTGCTGCCCTCGGCTCCGGCCGGTCTGGTGCGGGGCGTCGCCCGGCCCGCTTCCGCGTCCTCGGAGACGTTCAGCGGCGGCGGGCCGCTGCTGTTGCGTGCGGTACGGCGGGAGGAAGCGGAGGAGACCGCTCCTGCCGTCGGCGTGCGACAGGAGCGGGTGGTGGCCGCCCGGCCCCGGCAGGGCGAGCGGGCGGCGGGGTCCGGATCGGCGTCCCGGAAGGGCGCCGGGGCCGGGCGTTCCGGTGCGCCCGCGGTGCAGCGGCGTACGGCTGCCGACCCTGTCGGCGCTGTCACCTCTGTCGGCTCCATCGGCTCTGTCGAGGAGCAGCGGGGGCTCACGTCTTCGGGGTCTCCGGCTGTGCTGGGCGCCGGGGAGGCTCCGCCGGTGCAGCGGACGGCGGTTGCGTCGGCTGCGGCACCGAAGGCGTCGCTGCCGGTGGTGCGGCGCGTCGCGGTGGTGGAACCCCGTTCGGGCGGCGCTGCCTCGCCGGGTCCGGTGCCGACGCGCCCTTTCGCGCGGACCGAGAGCGTTTCGGCGCCGTCCGGCAGTGCCAGCGGGCGCGCCGCCGCCCCGGCCACCACGTCCGTGCGGCCGCTTCCGGTGGGCCGCTCGCTGATCGTGGCCCGGCGGCCGGCCGGTCCCGTGCGCCGGGTGACTCCGGTGGCGACCGCCGCCCCGAAGGCGACCGCGCCCACTCCGCAGGCCGAGCGGCAGCCGCAGGCCGAGCCGGAGCCGCAGGCCGCTCGGGCGGAGCAGGTGGACCGCGCGACGGTCCAGCGGCGCGAGGGGAGCCGTCCGCCACTGGGCGAACCCCTGACCCAACTCCCGCCCACCGCCGTGCCGATGAAGCATGGGGCCGTGGAAGGGAACACCGCGGGGCCCGCGCTTCCGGTGGTGCAGAGCAGGCCGGAGACGACGGCGGCCCGGGAGCGGCCCGCGCCGTCCACCGAGCCCGTCCAGCGCCGGGCCGAGGCGCCGGCTCCGCGTACCCGGTCGGGCCTGGGGGCACCCATGTCGGAGCTGCCGCCGACGGCCGACGTGCCCGGAAGCCGGGAGCGGTCCGGGCGGGCGCCGGTGCAGCGGTCTGCCGCGCCCGCGCATCAACAGCCGTCGCACAAGCCTCTGTTGGGCGGTGCTGCCGGCGCCGACAAGCCGACGCCCGACGCTGCCGTCCAGCGCCGCGCCACCACGGACTCCGCGTCGACGGGCACCCCCGCCGACTCGACCCCCCTGACCGTGGCCCGTCCGAGCGCCCCCGTGCAGGAGACACCCGGCGCCCCCGCGCGCCCCGCCGCGTCCCCCGAGGGCACGCGTCCTGCGGTCCAGCGCGCCCCGGCGAGCCCGGCTGCCACGCCCCGCACCTCCGAGCGCCCGACCCTGGGCGCCCCGGAGCGGCAGGGTCCCGTGTCCCCGGCCACGGCCCCCGACGGCCAGAGCCCCGCACGCCCGAGCACATCGGGCACCGCGTCCGGCACCGGCCAGAGCCCGGTGCCCCTGACCCCGGCGCGCCCCGGCACGTCGGCCCCGCAGGCGTCCGGCACCAACCCGGCTTCCGTACAACCGGCGTCCGTACAGCGGGCTTCGGCCCGCCCGAGCACGCCCGGCACCGCTCCCGGCACCACGTCCGGCGCTGCCCCCGGCACCGCGTCCGGCACCGGTCAGGGCTCGGTCCCCCTGACCCCCGCCCGCCCGGTCAGGCCCACCGTCCGGACCGCCCGTACCGACCAGCACCCCGCACACCCGGGCACCCCGGCCCAGCCCGCGCCCGGCACGGCCCAGTCCGGCATGCCCACCCGCCGGGGACCCGGCACCCCGGATGCCTCGGCACCCCGTACGCCAGGCTCCAGCCCGGCCTCCGCACCCGGCACCCCCGCAGCCTCGGCACCCCGCACCCCCGTACGCCCGCGCCCCACCCCCGGCACCACCCCCCTGGTCGTGGCCCGAGCGGTCACCCTCACCGGGCAGCCCGCCCCCACGGCCACCGCCAAGCCCTCCCCCACCCTGAACCTGCTGCCCGCCCGCCCCCTCACCCTCAGCACCGAGGAGGCACCGCCCATGGCCGCGCCCGCCCAGCGCAGGACGGCCGAACGCCCGGTGGTGGCCGCTCGTTGGGCACGTGAGCCGGCGGCCGGGACGCAGCAGCCGTCGGCCTCGGTCCAGCGGGCGCCCCGGTCCCCGGTCACGCCCTCCCCCTCCCGCGCCGCCCGCCCCACCCCGCTGGCCGCGACCCCCAGCGCCCCGGCGCCACGCCCGCTCCCGGTCACCGCGCCCCAGCCTCCGGCCGTACAGCCCTTCCTGGTGAACTCCCCCGCCCGCGAAGCCACCCCGGCGGCCCCCGCTCCGGTGGTCCGCCCCACGCGCGGCGGAGGCCCCGCCACGGCCGACGCCACGCCCCCGCTGGTCCGCCCCGCGCAGATCCAGCGCGACGTGGTCCCCACCGCGCCGACTCCCACACCCCCGGTGGTCCACACCCAGATCCAGCGGGACAAGACCGGCACCACCACCCCGCCCGCTCAGGGCACCCCCGCCGCGCAACCCGCGAACACCCCCTCGAAGCAGGGCAAGAGCTCCACCCGGAGCAAGCCCGCCGCCGCCGAGTCCTCCCCCGACCTCGACGACCTGGCCCGGCGCCTGCTGGACCCCGTCTCCCGTCTCCTGCGCAACGAGCTGCGCCGGGGCCGGGACCGCACGGGCCGCCCCTTCGACGGCCGCCGTTGAGGCACCCGCCGTCGGCCCACCCAAGACACCCCGCCACCCCTGAACGCCCCACGGACGGAACCCGAGCAGCATGACCGACAACATCTTCGCCACGAGCGTGTTCTTCCGGCTCGCCATCGGCGGGAACGACCTCGGTGCCTTCCACACGTGTTCCGGCATGGGGGCGCAGGTCGAGATGGAGACGTACGCGGAGGGCGGGAACAACGGGTTCACCTGGCAGCTGCCGGGCCGGGTGACCTGGTCGAACATCACGCTGACCCGACCGGTGACGGCGGACACGGCGAAGATCGGCCGATGGCTGGACGAGACGCTGCGCCGGGTGGAGCCGAAGGACGGCGAGATCGTGGCGCTGCGCCCCGACCTGAGCCGGATCATCGGCTGGCAGGTGTACGGGATCGTGCCGGTGCGCTGGCAGGGCCCGTCGTTCGACCCGGCCAGTTCCCAGGCGGCGGTGGAGACGCTGGAGATCGCGCACGAGGGGCTGGTCCCTTCCTGACCGCCCGCTCGTCCAGCCGAAGCCTCCGTTTCCCAGGAAGGAACCACCCATGTCCCCATCGGTCCGCGCCAGCCGGGCCAGGGCGCAGCTCACCCTCAAGGAGCCGCCGGCCTCGGTCGGCGCCAAGCCCGGCGGCACGCTCGCGCGGCTCGACCTCCAGTTCAACCCGTCGACGCTGGAGCTGAGCAAGTCCACCGAGTGGCGGCGCTCCCCCGCCCGCATGGCGGGCGAGTCGGCGCTGCCTGAGTTCGTGGGCAGTGGTCCCCGGGTGCTGAGCCTGGAGGTTTTCCTGGACGCGACGGCCACCCACGACAACTCCGTGGAGCAGGCCGTGGAGAAGCTGATGAAGGCGTGCGTGCCCACGCAGGCGAGCCTCGGCCGGAAGAAGCCGGCGAGCCCCTGGGTGCGGTTCGAGTGGGGCACGGCGCGTACGACGTCGTTCGACGGGGTGCTGTCCAGCCTGTCGGTGTCGTACACGCTGTTCGACGTGGACGGGAAGCCGCTGCGGGCCACCTGCTCGCTGTCCATCGAGGAGGCGAGCGTCGACCCGCCGGGGCAGAACCCCACCTCGGGCGCGCGGACGGCGCGCAGCACGCACACGCTGGTGGCGGGCGACAGCCTGGCGATGCTCGCCTGGCGGGAGTACGGGGACGCGACGGCCTGGCGGGCCATCGCCGAGGCGAACGGCATCGACGACCCGATGGCGCTGGAGCCGGGCACCGAACTGGTGGTGCCCGGACTGCGGGACGCCGGGTACGAGGAGGAGGAACGGTGACGGCTGCGGAGTCGGGTGACGTCCGGTCGTTCGCGGCCGACCCGGTCGTCGAGGCGCCGGGCGAGCTGCCGAAGACCTGGGCGACACAGCTGGTGAGCTGTGTCATCGAGGAGAGCGTGGGGCTGCCGGACACGGCGGTGCTGACCTACCGCGATCCGCAGCACGAGTTCCTCGCCGCGACCGGCGTCACGATCGGCACCCCGCTGAAGGTGTCGGTGGTGACGGTGAAGGGGCAGGCGAGCGAGCCGCTGTTCAGCGGTGAGGTGACGGCGCTGGAACTGGACCGGGACGGCACCGGCACGTTCACCGTGGTGCGCGCGTACTCCAAGGCGCACCGCTTGCAGCGCGGCCGGAAGGTGGTGGCGTACCGGGACATGACGACGGCGGCGATCATCCGCAAGGTCGTGACCTCGGCGGGGCTGGCCTGCGGCAAGGTGGAGGCGCCGGCGGTCACGCACAAGCAGCTCTCGCAGGCGAACGTCTCCGACTGGGACTTCCTGCAGTATCTGGCGGGCGAATGCGGGGCGCAGGTACGGGTGGACGACAAGGGGGTCGTCCAGTTCACGCGTCCGGTGAAGGCATCCGGGGCGCCGTCGCCGTCGACGCCCGCGACGCGGAGCCCGCTGGTGCTGGAGTACGGGCGGAACCTGCTGGCGCTGCGGGCGTCGCTGTCGATGGCGGACGCGGCGCAGAAGGTGCAGGTGCGCGGGTGGGACGCGACGACCAAGCGGGCGGTGGTGGCCGAGCAGGCGTCCATCACCAGCGGCACGGTGGTGCCGGGTCTGAATCCGGCGTCGGTGAACCGGTTCGGGAAGAAGACCCAGGTGACGGTGGCCGACACCCCGTACCGCACGCAGGCGGAGGCGGCGGCGGTGGCGCGGGCGACGGCGGAGCAGGTGAGCGCGTCCTACGGTGACCTGGAGGCGCTGACCACCGGAAATCCGGCGCTGCGCGCGGGCAAGGCGGTCGCGCTGGGCAACGTGGGGCCGGCCTTCTCGGGGCGGTACACGGCGACGGCGGTGCAGCACGTGCTGGAGCCGCACGGCGGTTACCGGACGACCCTGTGGGTCAGTTCCCGCCCGGACCCCTCGCTGACCGGGCTGTCCGGTGCCGGGGCCGGAGGATCGCGCGGTGCGCGCATTCCGGGTCTGGCGATCGGCGTGGTCACCGACGTACGGGAGCCGAACGGCGCGGAGCAGGGCGCGGTCCGGCTCAAGTTCCCCTGGCTGGACGATACTTATGTCTCGGACTGGACGCGTACCGTGCAGTGGGGCGGCAAGGGCGGCGGCGGTGTGGTCAGCCCCGAGGTCAACGACGAGGTGCTGGTCGGGTTCGAGCAGGGGCTGCTGGACAGTCCCTACGTCCTCGGCGGGCTCTACAACGGCGTGGACAAGCCGTCGAAGCACGATGTCCCGCTGATCGACAAGACCAGCGGGAAGGTCAACCGGCGCTCCGTCGTGTCGCGTTCGGGGCACCGGCTGGAGCTGCTGGACGCGCCCCGGCCGGGTCCGTCGGGGCTGCGGCTGGTGACGGCGGACAAGCGTCTGGAGGTCCGGATGGACGACCGCGAGGACCGGATCGAGGTGACGGTGTACCGCTCGCCGGGGCAGGTGGGCACGTCGATGGTGCTGGACAAGCAGGACATCACGCTGAGCGCGCCCCGGGGCGAAGTGACCCTGAAGGGGCGCCGGGTGACGATCGACGGACAGTCGCGGGTGTCCGTGTCCGGGCGCGCGGTGGCGGTGACCGGACGCTCCTCCGTCGAGGTGGACGGTGGTCTGCTGGGTGTCCTGAAGGCCAAGCTCATCCGGATCAACTGAGCTGTCCCGCAAGCTTGTTGTTGTCGATTACCGAGGAGTCCACGATGCCGGCCGCAGCCCGTACCGGTGATCCGACGAGCCATGGCGGCCGGATCACCACCCCGCCGCCCATGGCCGCCGCGCGGGTGGCGACCGTGCTGATCGGGGGCCGTCCGGCCGCCGTGGTGGGCAGCCTGCACGTGTGCGTGGTCCCGCCGCACGCGGCCACCGGCCCGGCGAACGTGATCATCCCCGACCCGATGGCGCTGGTCGGCGAGGGCGTGCTGATCGGTGGGCTGCCGGCCGCGACGATGGGCGACAAGACGGCGTGCCAGGCGCAGATCGTGATGGGTGAGTTGAGCGTGGAGATAGGTGGCGTGCTGTGAGCGAGCGGTTCATCGGCCGGGGCTGGGCGTTCCCGCTGCGGGTCGGCCCCACCGGCGGCATCGCCATGGTGGAGCGGGCGCGGGAGATCGAGGAGGCCATCCGGCTGGTCCTCGGCACCGCGCCCGGCGAGCGGCCGATGCGGCCCGAGTTCGGCTGCGGCATCCACGACTACGTCTTCGCGCCGGGCGACGGCGACACGGCGGGCCGGGTCGCGCAGCAGGTCCGGGAGGCCCTGGAGCGGTGGGAGCCGCGGATCTCCGTGGACGACGTGGTGGTGGCCTTCGACGCGGTGGACGCCGGGACGCTCTACATCGACGTGCACTACACGGTGCGGTCCACCAACGACCGGCGCAATCTGGTGTTTCCGTTCTACACGATCCCCTCCGAGGAGGGTGTCGAGGAAGTGGTCGGCGACTGATGGTCCTGCCCTCCCCCAATCTGGACGACCGGCGCTTCCAGCAGCTCGTCGACGAGGCGAAACGGTATGTGCAGCAGCGTGCCCCCGAGTGGACCGACCACAACGTGTCGGACCCCGGTGTCACGCTGATCGAGACGTTCGCCTATCTGGTGGACCAGCTGCTGTACCGGCTGAACCGGGTCCCGGAGAAGAACTACCTGGCGTTTCTCGATCTGTTGGGCATCCGGCTGTTCCCGCCGTCGGCCGCGGCAGCCGAGGTCGACTTCTGGCTCTCCGCGCCGCAGCCGGAGCCGGTGACGCTGAGTGCGGGCACCGAGGTGACGACGGCGGCCGGCGAGGACGAGGACTCCGTCGTCTTCGCCACCACCGGTGAACTGCGCATCGTGCCGAGCGAGTTGATCAGGCTGGTGACGGCGCCGCGCGGCGGTGAGCAGACCGACCGGACGAACGCGCTGGCCGAGGGCCGGGACGTGCCCTGCTTCCAGACCACGCCCGAGCCCGGTGACGCGCTGCTGTTCGGGCTGCCGACGGCGGTGCCGCGCTGTGTGGTCGCCGTCCGCCTGGACAGCCGGGTCGAGGGCGTCGGCGTCGACCCGCGCCAGCCCCCGCTGGTCTGGGAGGCGTGGGACGGCACGCGCTGGCTGCGCTGCGAGACCGGCGAGGACACCACGGGCGGTCTGAACCGGCCCGGCGAGATCATCGTGTACGTCCCGGCGTCGCACACGGCGTCGGTGATCGGCGGGACGCACGCGGGCTGGCTGCGCTGCCGGGTGGTGCCGGCCGAACCGGGCCAGCCGTTCTACTCCGAGTCGCCGACCGTGCGGGAGGCCGCCGTGTTCACGGTGGGCGGCACCATGACGGTGGAGCACGCGGAGACGGTGACGGACGTGCCGCTCGGCGCCTCCGAGGGCGTCGCGGGACAGACGTTCCGCCTCGACCGGCCGCCGGTGCTGCTGGACGGCGAGCCGCCCGTGGTGGAGGTGTCCTCCGCCGACGGCTGGCAGCGCTGGCAGGTGGTCGAGCACTTCGGCCGCTCCGGCCCCGAGGACCGGCATGTACGGGTGGACGCCACCTCGGGCGAGTTCGGGTTCGCGCCCGCGCTGCGCGAGCCCGACGGCACGCTGCGCCCGTGCGGCGCGGTGCCGCCCAAGGGCGCCCAGGTCCGGGTGGCCCGCTACCGCACCGGCGGCGGCCCGGCGGGCAACGTGGCGCGCGGCGCGATCAACGTGCTGCGCAGTTCGGTGCCGTACGTGGCCCGGGTCGGCAACCGGGAGGCGGCCCGTGGCGGGGTCGCGGGTGAGACGGTGGCCAACGCCCGGCTGCGCGCCCCGCAGGCGCTGCGCATGCAGGAGCGCGCGGTGACCGCCGAGGACCACGAGATCATCGCCCGGCAGGCGGCGCCGTCGGTGCGCCGGGTGCGCTGTCTGCCGGCCGCCGACGAGCCGGGCGCGGTCCGGGTGCTGGTGGTGCCGGACGCGGTGCCCGACGACGACGGCCGGGTTCGCTTCGAGCAGCTCATCCCGTCCGACCAGGTGCTCGCCGCGATCACCGAGGCCCTGGACGAGCGGCGCCTGATCGGCACCCGCCTGGTGGTGGAGCCGCCGGTCTACCAGGGCGTCACCGTGGTGGCCCGGCTCACCGCCCCGGCCGCCGTCGCGGACCGGGTACGGGCCACCGCACTGGCCGCGCTCTACGACCACCTGGACCCGCTGCACGGCGGCCCCGACGGCACGGGCTGGCCGTTCGGGCGCCCGGTGCAGTACGGGGAGGTGTTCGGCGTGCTCCAGCGTGCCGTGGGGGACGTGCTGGTGGAGGACATCCGGCTGTTCCCGGCCGACCCGGTGACCGGGCGACGCGGTACGCCGGTGGACCGGGTCGACATCGGCGCGGGCGCGCTGGTCTTCCCGTACCAGCACCAGGTGGTCGTCACTGCGGCGGAGCCGGAGGCGCGGGTATGA

Protein sequences of DBSCAN-SWA_1

>CP032229|586925:616010|591683_594398_+|QBJ89338.1|DBSCAN-SWA
MAGAALVGAYALPASAAPARVAALVAHPADLVNPFIGTSNDANDFPGADVPFGMVQWSPDTSSRPPGGGYEYKDASITGFSLTHIAGPGCGAAGDVPVLPTVGAVNNSATDSFSHANESATAGSYKVALDNKVTTELATTARSGMARFTFPATTQANLLFKLNSSQNGGSSTQFNVVSSTEVSGQVTSGRFCGAGNSYTVYFDMVFDRPFATSGSSLAPEKPAPSAKRAGKNAADKPNHPRLHGTAPKSVKGGATPKAAASNAHVTFDTSSSQTVQAKVGVSYVSIANASANRVAENPNWNFDAIRTSAHDAWDSALGKVLIGGGTSDQQKIFYTALYHSLLHPNVISDTNGQYFGFDGRTHTVDSGHRAAYANYSGWDIYRSQAQLEALVSPQVASDTAQSMLDDYQQTGIFPKWSENNGESYVMVGDPAAAIIADYYAFGARNFDTSAALAGLLKQASTANNDRPGLSYLDNPGYEPHDGSYGCCNFYGPVATTLEYNTADFALSAFAGALGDSGSQKTYAHRAQDWRNVLNPASGFVQPRNLDGSWTGGFDPTSGTDMVEADSWIYTGMVPFNVAGLATAKGGNKVMGDYLDTVLRSYTGANGYAWVGNEPSIELPWEYDYIGMPYKTQATVRAVQDQIWSNSPAGLADGNDDLGAMSAWYVWSALGMFPMTPGTADLALGSPLFPQAQVTLPSGKTLTVNGTGAADNAPYVQSATFNGSAWNNAYAPTSALTSGGTLGFTLGTTANTGWASGTSAAPPSYPDDTSAPAKPRVGPVKAGVSSSLCVDDANSGTADHTAIQLWTCNGTYAQDWTVASDGTLRTLGKCLDVTNSGTVNGTLVQLYACNGTGAQKWTAGSDGSLKNANSGLCLDDPNSATAEGTRLQIYTCNGSAAQKWTLPAA
>CP032229|586925:616010|594487_595726_-|QBJ89339.1|DBSCAN-SWA
MRTHRHGTDRDGTHGPDTDRARRAGAPAPPLLALQRSAGNAAVSRLVADARTEDVVQRSPEPSRPPSRTSQKSGDSQETESSQESAHSMTAVDRRKIKFAQDKAELLGRVGRIEVLKNVPGFMSGLDAFLDNIEADMKAGQPTAVDGAAIDRIIDGFHDPRVQGHRVQYSWFVRQQGKEGFQGALDRVAAGSTEHGHLWSKMNSAIPTEDASVGHGVVLEASIQGRIFDGLLFGLPTWSASDALAALWKRLSTTYVQALTGTVTAHALDGTVGSSVLSTLEWPELRASIADNRVDGLSFVVYRSREDPSGGPMILEPVETFQVRTQDEFDNLPEAPADQSWRDGQRVIDQQQRAALADIHSREDEILALDEFVSDLFRRHGRDLRFRDTRTPPNTRSQSARESPRSGSPGGA
>CP032229|586925:616010|604499_606059_+|QBJ89343.1|tail|DBSCAN-SWA
MPTYLTPGVYVEEVQSGARPIEGVGTAVAAFVGFAEDGPFHEPTLVTSWDQYTRTFGGFVQGAYLPHSVYGYFANGGGSAYVVRVGGSADDSSAPAGNGDGARREQAALAVEVGGFQIAAKPGVSGVSIEIADPEGENPPEDRFRVLVRQGEQVAETYDASTRRNVKGYLPTQARNSKLIEVTEQRGGNQTRPAAQTIAVPDAPASPAPATSGQVARLDPAEYVGDADARTGFAGLESVDEITMVAVPDLMSAYQRGDIDAEGLRTVQLAVISHCEQMGDRVAVLDAPPGLSAQQVRNWRNDEAGYDSRYATLYYPWVRVLDPAAGRNITVPPSGHVAGLWARSDTERGVHKAPANEVIRGAVDLELRLSKGEQDLLNPIGVNCIRTFPGRGVRVWGARTLSSDPAWRYLNVRRLFNYLEESILLGTQWVVFEPNDDRLWSSIRRNVSAFLTEEWRRGALFGRTAAEAFYVKCDRDNNPQESIDQGRVVCEIGVSPVKPAEFVVFRLAQFSDSTSLVDE
>CP032229|586925:616010|595987_597292_-|QBJ93966.1|DBSCAN-SWA
MPAVSVTPGGLATTTLTVRNDSDIVEAYGLEVVGDCAAWATVEPARVSLYPGTSETVTIRLEPPRSPEVRAGEVPLAVRVLPTEHPEAVRVPESTVRVEEFRELRAEIAPRRRRGWLRGRYRLALRNEGNSPVTLGFTPAQPGEELRFTLKPAEQALEPGESAEVGLRARIGKPVWFGAPVIWPFTVTVAETAAPDATLPERPDTIRTSLDAEFVQIPVFPKWLLAVLAALIALLLAWFTLVRPAVRSAAKEAADEVVQQRPTPGGSEQAGQGTGADGGRPGTGGGGAGSQPGTGGGDGTGTGTGTGNGGGGGGAGGGQSSATIDVQTGGGAEKTGTYTVPADKVFQVTDIVVANFQGDEGVLTINFGDRKITTIALETFRNQDYHWVTPIRISANDTVTAQVTCAKPGTPATGRRAQECHEVLNVSGVLSDIR
>CP032229|586925:616010|611444_613268_+|QBJ89349.1|DBSCAN-SWA
MTAAESGDVRSFAADPVVEAPGELPKTWATQLVSCVIEESVGLPDTAVLTYRDPQHEFLAATGVTIGTPLKVSVVTVKGQASEPLFSGEVTALELDRDGTGTFTVVRAYSKAHRLQRGRKVVAYRDMTTAAIIRKVVTSAGLACGKVEAPAVTHKQLSQANVSDWDFLQYLAGECGAQVRVDDKGVVQFTRPVKASGAPSPSTPATRSPLVLEYGRNLLALRASLSMADAAQKVQVRGWDATTKRAVVAEQASITSGTVVPGLNPASVNRFGKKTQVTVADTPYRTQAEAAAVARATAEQVSASYGDLEALTTGNPALRAGKAVALGNVGPAFSGRYTATAVQHVLEPHGGYRTTLWVSSRPDPSLTGLSGAGAGGSRGARIPGLAIGVVTDVREPNGAEQGAVRLKFPWLDDTYVSDWTRTVQWGGKGGGGVVSPEVNDEVLVGFEQGLLDSPYVLGGLYNGVDKPSKHDVPLIDKTSGKVNRRSVVSRSGHRLELLDAPRPGPSGLRLVTADKRLEVRMDDREDRIEVTVYRSPGQVGTSMVLDKQDITLSAPRGEVTLKGRRVTIDGQSRVSVSGRAVAVTGRSSVEVDGGLLGVLKAKLIRIN
>CP032229|586925:616010|610722_611448_+|QBJ89348.1|DBSCAN-SWA
MSPSVRASRARAQLTLKEPPASVGAKPGGTLARLDLQFNPSTLELSKSTEWRRSPARMAGESALPEFVGSGPRVLSLEVFLDATATHDNSVEQAVEKLMKACVPTQASLGRKKPASPWVRFEWGTARTTSFDGVLSSLSVSYTLFDVDGKPLRATCSLSIEEASVDPPGQNPTSGARTARSTHTLVAGDSLAMLAWREYGDATAWRAIAEANGIDDPMALEPGTELVVPGLRDAGYEEEER
>CP032229|586925:616010|597553_598261_+|QBJ89340.1|DBSCAN-SWA
MTTSCPQANHPAPAAHTAPWTTSARRPERVSVTVYAPDPVLYVGIVHQLRQRPEIEFVEAGAADSAQVSLITVDTVDDETSALLNRLRHNSATRTGLVVGTFESGDALQRAIDNGVAAVLRRAEADQDRLLRLVLAIANGEGMLPGDLLAKLLTHVGSMQRSSPLDPRAASLSTLAPRETEMLRLVAEGLDTGEIARKTSYSERTVKNVLHEVITRLQLRNRAHAVGYALRNGLI
>CP032229|586925:616010|606107_606548_+|QBJ89344.1|tail|DBSCAN-SWA
MAEGDALSTHIFGVQLGGYLVESIQEISGLSVEEEVVEVRQVSSEGKQIIRKQPGARQAGEITITRGLDQSSEFTSWIKETLNNGAVDTARQNLTIEIKDSTGETVRRIQLMQGWASKWEGPSLKAGESSAATESVTIVFEEIIVE
>CP032229|586925:616010|614051_616010_+|QBJ89352.1|plate|DBSCAN-SWA
MVLPSPNLDDRRFQQLVDEAKRYVQQRAPEWTDHNVSDPGVTLIETFAYLVDQLLYRLNRVPEKNYLAFLDLLGIRLFPPSAAAAEVDFWLSAPQPEPVTLSAGTEVTTAAGEDEDSVVFATTGELRIVPSELIRLVTAPRGGEQTDRTNALAEGRDVPCFQTTPEPGDALLFGLPTAVPRCVVAVRLDSRVEGVGVDPRQPPLVWEAWDGTRWLRCETGEDTTGGLNRPGEIIVYVPASHTASVIGGTHAGWLRCRVVPAEPGQPFYSESPTVREAAVFTVGGTMTVEHAETVTDVPLGASEGVAGQTFRLDRPPVLLDGEPPVVEVSSADGWQRWQVVEHFGRSGPEDRHVRVDATSGEFGFAPALREPDGTLRPCGAVPPKGAQVRVARYRTGGGPAGNVARGAINVLRSSVPYVARVGNREAARGGVAGETVANARLRAPQALRMQERAVTAEDHEIIARQAAPSVRRVRCLPAADEPGAVRVLVVPDAVPDDDGRVRFEQLIPSDQVLAAITEALDERRLIGTRLVVEPPVYQGVTVVARLTAPAAVADRVRATALAALYDHLDPLHGGPDGTGWPFGRPVQYGEVFGVLQRAVGDVLVEDIRLFPADPVTGRRGTPVDRVDIGAGALVFPYQHQVVVTAAEPEARV
>CP032229|586925:616010|606544_607042_+|QBJ89345.1|DBSCAN-SWA
MRRRTVTAGNLDEILQATAPAKDEAEAVSKPFTPAAPPRQEPALRTEFEFELPRGYVDEAGTVHRHGSMRLATARDELRPQIDLRVKENPAYLSVVLLSQVITRIGTVTDVHAGIVERMYATDVAFLQDFYRRVNSEGHTRAAVTCPHCEGGFEVDLSGGRLGES
>CP032229|586925:616010|602312_604358_+|QBJ89342.1|DBSCAN-SWA
MTHPVEPELWHRLHTVEERVRKAVAARRAVDPDPDDPYRGQYLTPEAAQRVLDTRAEPSATEPERSAEDTPLGRLARDFGLSPLDLDLLLVALAPDLDARFEQLYGYLNDDLTRRRPTVGLALELCGHTGLSPARFRLSPGAPLLAGGLLEVHEPERPPLSRVLTVPDRVTAHLLGDTAPDARLGSVLGEQTADPAADPALVRRAAAGVRSGTGHVHLRAVGGAPEGLADAALREAGRVPLVLDAVALARHARDLPSLAAAAAREARLTGAGVVLGPLDDLPDKPAERTHVLRTVCAALSGIPLFTYGAQVWDPGWAVRTPVSFTVGTSSPEQQAVRWRFALEASGAPDGSGSEDLARAVAAHRLDSGQLRRAADAAVRTAGLAGRPVDAEDVRAAVRAQNGAGLARLARRVEPAVGWDDLVLPPRTLRGLRELAVRARHRDQVLGRWGMRPGGGRGRGVIALFAGESGTGKTMSAEVVATDLGMDLYVVDLSTVVDKYIGETEKNLERIFTEASAVNAVLLFDEADAIFGKRSEVKDARDRHANIESAYLLQRMESFDGIAVLTTNLRANLDEAFTRRLDVVADFPMPDAAQRLALWERCLGDRLPRAEDVDLKFCADRFELAGGSIRSCAVTAAYLAADSGNELTMRQVVQSVAQEYRKLGRLVLAAEFGPWLAQVTAA
>CP032229|586925:616010|601608_602316_+|QBJ89341.1|DBSCAN-SWA
MIHEVDEALRGLLEESGLAASGVEVVFDAPTSDWAARRSAPTVCAFLYDIREDNSRRNSSAGEIYDEDGFVVARRSPARWFELTYLVTAWASRPQDEHRLLSQVLSTLVSTDTLAPRLLTGSLAELGLIVGLDAGGTGLDAPAASDVWSALGGELKPSLGLRVRAPLAGIERVAAPPVTEGLVVRSVPHSLPDEPESTRRLRYAEIDDPGGEGFGGSRERRPAPARRRRRGDRQP
>CP032229|586925:616010|588025_588598_-|QBJ89334.1|DBSCAN-SWA
MASSITAPVPVKSDTAALRRLYFLRFAFAAVWAALVFATAHTLSPLGATLLVLYPLFDVACAVVDLRSARANQGPVRGLCANIALSTLTTAGLAAAATSGIPAVLRVWGAWAVTAGAVQLIVGALRRRHGMAGQWPMILSGAISTLAGASFIAQAAKPDASLGSLAGYAFLGGVFFLVSALRLGRADKVG
>CP032229|586925:616010|586925_587879_-|QBJ89333.1|transposase|DBSCAN-SWA
MPHRNARLTVFGRRLLVERVRSGRPVAHVAAEMGISRATAHKWIRRWRTEGEAGLQDRSSRPRTTPHRTASAVEDRVCDLRQSRKLGPARIGPIVGLPTSTVHRILTRHRLNQLAWIDRPTGTVIRRYERDRPGELIHVDVKKLGRIPDGGGHKTHGREAGRPIRGMGFDYVHSAVDDHSRLAYSEIHPDEKAATCAGFLTRAAAFFHAQGIDRIERVLTDNAWAYRKGLAWKKVLTEIGAAGKLTRPYRPQTNGKVERFNRTLLDEWAYQRPYTTNTERTDALADFLHTDNHHRCHTALGGHPPISRVNNARDQYT
>CP032229|586925:616010|598477_601612_+|QBJ93967.1|DBSCAN-SWA
MLLLVPLLAVTAAAGPGTAKARPRAGDEGVTRIAYAGTRHRSLGRVETTKSSAPLFGVGATHYDVEPSALGDQLVFASRRDERNPQVYLRAADGSVAKLTSGRDAAHPRLTPDGRSVVFDSAEPGGPGGATQRDLWLVRTDGTGLTRLTNTPADEECPTVSPDGQRLAYSSDADPLVGQQVYVRPLGGGTVNRVTDPANGTASEPAWNPLDNAEKRDIIAYTATTADGPKLRYVYASSGDGGPLLGATEAGWRTHGAAWLPDGNQLLFLSPDRDCTCEGDFDHVFKTVVHSDNDANRSLVLTEDREVGTVTWLGPVDGGGTVVDRTTAAGPHVVTLQDARADGSDPRDLGLTILNEDPAADTNTDPTKDPLFQPAAGSDPWTERQNYTPDGRQIVLTRFEDSDAGRIERIWLADADGSNARPLPLAGRGAKDWDTDPTFSPDGRYIAFRRTSPGGTGDAAGPSKVLIADVATGALRGTITPPAGQAQGTDAQPTWSSDGTQLAFTRTQVINGGNGNKHIWTVPVDRLGQQRDLSAADCPGACDVIDDSPAFSPDGQTIAFNRKAGGGRVDQQGGLLLTSVSGDDCRVLLPAAGRGLPGACGRELPNAGTGPFQPRDAAWTADGTALVFSSRAQLAANSPEKLSRVDVESGALTPLTTGLAGRQKEPSVQQSVDLAVQAPDTSGQVIVGRTGTVRVDVVNQGPAASPGTRFTVAPPLGATVTGLTAPGRNCDVRGLTCDLGVVPPGATVPVTVTFTGVTPGDQPVDWSVTGAVIDPDPSDNTDRTVVPVREAPAPPDPTPSPAPPTPTPPTTPPVPPAPPAPPVPEPPAPKAGPGVTVTANPNPGYVGGRVVVTYTVRNGRNALATGLRLRIGLPADIPNNGRPPGCDANWLCALPDLAPGARSTLQVVLTPKKALTAEVTGTLTTTGTDADRGDNSARQRLRVLQPKIVAVPPIGKPGFVTSVRGKDFPPGVPVRFRWKPGITAAAAPTVPLPDGTFIGQLLILAKDQTGPRTITASGPGFSPVKTDFLVVNGSVQPPDEVTRR
>CP032229|586925:616010|590736_591459_+|QBJ89337.1|DBSCAN-SWA
MEDVTPLSPRPLSRVLFRQWWRELVFLHWEVDPDEVARLLPPGTCPDLHEGRAYVGLVFFRMDHLAFGRGPAVSYLGSFGEVNVRLYSRDALGRRGVVFRSLDCDRLLPVLTARTAFGLPYRWARIHTRRTATGISYASLRRDGSGAGARVRADISPEPYEATTLEHFLTCRWGLHAQLRGRTYYLPNTHPRWTFTHCDLTSYDESAIAAAGLPAPADAPVSVLHAPGVPVRFGPPQRLP
>CP032229|586925:616010|588724_589306_+|QBJ89335.1|DBSCAN-SWA
MSTRTEGKSTSEARARLLDTATRIFYAEGIHSVGVDRIIAEAQVTRATLYRHFKGKDELILAYLQQADRGIRGQVDAVRAQGLPPAETVRAVGRSIAEGIRSPGFRGCAFLNAAAEYPDPAHPVHQAVLAHRQWFLETATQLMDDAGCSPAEVTGRHFVMLRDGAMAAGCLFDPALICATFLDGVEGILRTGA
>CP032229|586925:616010|613629_614052_+|QBJ89351.1|plate|DBSCAN-SWA
MSERFIGRGWAFPLRVGPTGGIAMVERAREIEEAIRLVLGTAPGERPMRPEFGCGIHDYVFAPGDGDTAGRVAQQVREALERWEPRISVDDVVVAFDAVDAGTLYIDVHYTVRSTNDRRNLVFPFYTIPSEEGVEEVVGD
>CP032229|586925:616010|590020_590716_+|QBJ89336.1|DBSCAN-SWA
MEIRGARVLVAGATGDIGSALAERLAGVGAVTALAGRDPARLAGVRERCGPGPSRIFDAWDLDGAEGTAAWAARELGGLDAVVVCVGVAAFGPVGEIGEAVAEHVMAVNALAPMAILRSASAHVSPGGLLAAVTGTVARSAPAGMADYAAAKAALATWLTATRRELRRAGVGVLEVCLPHVESGFAGRAVTGTAPPLPPGITVAEAVDVIVEGMRMDARVVDSARSKRGTT
>CP032229|586925:616010|610247_610673_+|QBJ89347.1|tail|DBSCAN-SWA
MTDNIFATSVFFRLAIGGNDLGAFHTCSGMGAQVEMETYAEGGNNGFTWQLPGRVTWSNITLTRPVTADTAKIGRWLDETLRRVEPKDGEIVALRPDLSRIIGWQVYGIVPVRWQGPSFDPASSQAAVETLEIAHEGLVPS
>CP032229|586925:616010|607276_610177_+|QBJ89346.1|DBSCAN-SWA
MERASAGVGVPESWDGGWRAAATPELTVSRAPLAVSDGLGFRAGLAAWRDPSFDTGLAHGVLPSAPAGLVRGVARPASASSETFSGGGPLLLRAVRREEAEETAPAVGVRQERVVAARPRQGERAAGSGSASRKGAGAGRSGAPAVQRRTAADPVGAVTSVGSIGSVEEQRGLTSSGSPAVLGAGEAPPVQRTAVASAAAPKASLPVVRRVAVVEPRSGGAASPGPVPTRPFARTESVSAPSGSASGRAAAPATTSVRPLPVGRSLIVARRPAGPVRRVTPVATAAPKATAPTPQAERQPQAEPEPQAARAEQVDRATVQRREGSRPPLGEPLTQLPPTAVPMKHGAVEGNTAGPALPVVQSRPETTAARERPAPSTEPVQRRAEAPAPRTRSGLGAPMSELPPTADVPGSRERSGRAPVQRSAAPAHQQPSHKPLLGGAAGADKPTPDAAVQRRATTDSASTGTPADSTPLTVARPSAPVQETPGAPARPAASPEGTRPAVQRAPASPAATPRTSERPTLGAPERQGPVSPATAPDGQSPARPSTSGTASGTGQSPVPLTPARPGTSAPQASGTNPASVQPASVQRASARPSTPGTAPGTTSGAAPGTASGTGQGSVPLTPARPVRPTVRTARTDQHPAHPGTPAQPAPGTAQSGMPTRRGPGTPDASAPRTPGSSPASAPGTPAASAPRTPVRPRPTPGTTPLVVARAVTLTGQPAPTATAKPSPTLNLLPARPLTLSTEEAPPMAAPAQRRTAERPVVAARWAREPAAGTQQPSASVQRAPRSPVTPSPSRAARPTPLAATPSAPAPRPLPVTAPQPPAVQPFLVNSPAREATPAAPAPVVRPTRGGGPATADATPPLVRPAQIQRDVVPTAPTPTPPVVHTQIQRDKTGTTTPPAQGTPAAQPANTPSKQGKSSTRSKPAAAESSPDLDDLARRLLDPVSRLLRNELRRGRDRTGRPFDGRR
>CP032229|586925:616010|613312_613633_+|QBJ89350.1|DBSCAN-SWA
MPAAARTGDPTSHGGRITTPPPMAAARVATVLIGGRPAAVVGSLHVCVVPPHAATGPANVIIPDPMALVGEGVLIGGLPAATMGDKTACQAQIVMGELSVEIGGVL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBJ89333.1|586925_587879_-|transposase	IS481 family transposase	NA	NA	NA	NA
QBJ89334.1|588025_588598_-	hypothetical protein	NA	NA	NA	NA
QBJ89335.1|588724_589306_+	TetR/AcrR family transcriptional regulator	NA	NA	NA	NA
QBJ89336.1|590020_590716_+	SDR family NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
QBJ89337.1|590736_591459_+	DUF2071 domain-containing protein	NA	NA	NA	NA
QBJ89338.1|591683_594398_+	hypothetical protein	NA	NA	NA	NA
QBJ89339.1|594487_595726_-	hypothetical protein	NA	NA	NA	NA
QBJ93966.1|595987_597292_-	hydrolytic protein	NA	NA	NA	NA
QBJ89340.1|597553_598261_+	DNA-binding response regulator	NA	NA	NA	NA
QBJ93967.1|598477_601612_+	hypothetical protein	NA	NA	NA	NA
QBJ89341.1|601608_602316_+	DUF4255 domain-containing protein	NA	NA	NA	NA
QBJ89342.1|602312_604358_+	ATP-binding protein	A0A0R6PCP6	Moraxella_phage	5.1e-25	30.6
QBJ89343.1|604499_606059_+|tail	phage tail sheath family protein	J9PVC2	Bacillus_phage	2.7e-66	33.4
QBJ89344.1|606107_606548_+|tail	phage tail protein	NA	NA	NA	NA
QBJ89345.1|606544_607042_+	hypothetical protein	NA	NA	NA	NA
QBJ89346.1|607276_610177_+	hypothetical protein	NA	NA	NA	NA
QBJ89347.1|610247_610673_+|tail	phage tail protein	NA	NA	NA	NA
QBJ89348.1|610722_611448_+	LysM peptidoglycan-binding domain-containing protein	NA	NA	NA	NA
QBJ89349.1|611444_613268_+	type IV secretion protein Rhs	NA	NA	NA	NA
QBJ89350.1|613312_613633_+	hypothetical protein	NA	NA	NA	NA
QBJ89351.1|613629_614052_+|plate	baseplate protein	A0A1D8KT65	Synechococcus_phage	4.4e-08	31.2
QBJ89352.1|614051_616010_+|plate	putative baseplate assembly protein	NA	NA	NA	NA

2. CP032230

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	0 : 10694	8	Mycobacterium_phage(50.0%)	tail	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>CP032230|0:10694|DBSCAN-SWA

Protein sequences of DBSCAN-SWA_1

>CP032230|0:10694|9887_10694_-|QBJ94422.1|DBSCAN-SWA
MLLAKPKKYMRRGTSKFYFVPTIAATTMIPTRSELGAGTDFTAFIAAMDGWTVTNQEIDTPDMADTYDATIPGSDKADSSSFTFYEDEEDADLEQLFAKGTTGYVVILRKGDIPGNNSMDVFPIRVASQSPQYTADNEAAKFMATCSITSRPLQGAPVPASGTDEVQTVTITGTPTGGTFTLTFNGQTTSAIVYNATSSAVQSALEALSNIAPGDITCTGGPLPGSPVTVTFSGGAYDGTDVPQMTAAGSFTGGTSPAITVATTTPGG
>CP032230|0:10694|9227_9782_-|QBJ94421.1|DBSCAN-SWA
MTSTTRTKPQPPAAAVAADAHWAAKMDRLRSRALAETVFVVCDDQSVRDRYLRAQRDYDLAAQYAKANPKDTEAASDLTRATEARDDAKQAYDEVSIPIRFRALPRQALEALYEQHAPSETDTEDGKRWADSFPAALIAAACVDGMTETEAQELLNSWSLAEADAMFNAAYGVQNTTRTDLGKG
>CP032230|0:10694|1727_2663_-|QBJ94418.1|DBSCAN-SWA
MSFFPRPILTNGATHSAQQFRMLVRDLARGAEGITQGDDLKVTQRTTPGGGVLLADGSGVIRGRDNVFQGTYAFCNIGAVDVPIAATGASARSDMLIVRVEDPEYGYSRNPQTDDIVFPQIISGVSSSATSIPDGRTGIPLARIDIPANSGTITNAMITDLRKVANPRRDRRLYTQSPTADSSLIGSSTSYSYFSTAAGWNIAIPDWATTVRLRVDVSPLRYSVNDYVGNLRATFGASLTLQATGLDDNQGNVVRKIPAICADTLTVPAAYRATTQLLRAQANGGTGNAGRINVTSVTTLIADVEFEEAPR
>CP032230|0:10694|0_619_-|QBJ94416.1|DBSCAN-SWA
MDLGRELNLHSQRLDRLERASRLSHASIENTAIQVNDGNGSLRAIVGVQGDGTTAVNIVNGGPPPTPSTPTVSSGLGGLAVGWDGTSADGSIAPMDWSRVEVHVSPTAGFTPTTATLRATIETPQGGICYIPVTGASYVCLLARNTSGTASTATTPVGPYSPRPVAGDIGIGEIINTMISDGAVTTPKLYANAVTTPKIQAGSVDA
>CP032230|0:10694|618_1731_-|QBJ94417.1|DBSCAN-SWA
MTGPHIPDRILTQNIVTGAWLATALPVIEPEYGDELCGPGSFTGRLSPRLYSSNPNVVDPGNTFLFVESAGQLQWGGIVWDIRASGSDYAIEAASWSSYLQHRYDLDDEHGGRGPYTYADRCQVIRNIWAYAQSAADGDLGVTVDATTSTSTIGTPADPYQSNWWETPCLGDQIDDLVSGDSTPDYTCSTAWNTAKTGVVKRIRLGWPRLGARRTDLSFASGVNIIDEPEDALTGDDYAQVVVAAGAGEGRSRLRQTSAVRNGRLRMEYVLDLPDVNGIDILRARADRERTWRQTTVRGSVDQITVRDTPSAPFGSYQVGDDVMVRVNNPWTSYAGWCRITGWTRKPQAQGGPQTVLSLKPADSYQYGGV
>CP032230|0:10694|3564_8826_-|QBJ94420.1|tail|DBSCAN-SWA
MANWNLSVDLKGNGNDLSQALKSSAKRARSLGTAAKTAKTEVKELGLAAEAAGKHIKTLGTEARTAARRLNSLGDNAQTATRRLNRYGDAAQSAHRHVTSLGENSRTTGRQLARMSGQIDTAVRDLARLATAAQRADSRMARMGLRGSGSLRRYRDEASRAHSALKSLAGVGATLGLALGVHEVIEEGGQYQQAMNAFGATTGATQMQMKRASATANQLGNDLKLPGATAADAAEGMVELAKAGFRTDQAISATRSSVILASAAQVNAADSAKYLGDMMDQFGMGADQSAKAADTLAATANAASGEIIDIYYAMKYAGPVAHGLGLSMQETAAAVGMLGKAGILGQTAGTTLRGMMANLAAPTPQMIEGLKAMGIEAWDAQGNFKGLRNVIDGLSKAQHHMTQQDFAAAVKKSMGKPAMSGAIALAHQGVESYDNMLQAAHQVGAATDIAAAKGKGLAGAMLQLGTQAKQTGLTIYQGMAPGLEFLTRGVTAGLSEATPKIEHFFNYFNDLATLFGPEVSAAASREFAGIADAASNLAGPLKDLGEEALADFLHVLVNVGGAAVHVLENLAAGVQPVLGAFSGVAGESDAVSSSLDIVVAALDLAATAAEDLSGVLIPIGQVVGGLVSAFGSLPGPVQQFVLAALLVRRIQGPMVGLANTVNGRVRGAFQSLNQQMAVQRSLAGAAGMSLSRYGAAMATLQARVPIFGQMGAAFRTASAQGAGFAGTLRGVGAASMTATRAIGSGLMGALGGPVGLAITAATVGLGYLASRQQAAAAAAAEHRQQVSALSEALRQSNGAVDDNVRAVAAQTLMSQKAKSWYGDQKRLVDLAREAKVPFSQLVDAYTGQGTSLSALQRELSGVVKEHTKWTTDLESGAAVKAPDRIGKAAQALSQGLGGLSGDFSKAAADAKSYNEAVKGAQGGETAYGRLKDAVAALADKTGDADQRTRALRDALDLLSGGSVSLQAAQARVNEAITQANEAMQSGINKADGFGKALVNANGTLDTTTKNGQALFSTFNTIADGASNASIAAYDFAQSQGKSLPQSLAAAQKEMQTARDSAVKLAQGYGLSADQAGKVADSLGLIPGQVSILLETKGVDSTLAELLAVQAEFQKMPTAKTIRVDALGEEAKRELEDLGYKIKLIPGTREYKITAPTKAARSQLDLLISEMAKVPPGKDVRVDVHKVQAVAGLNEVQAQIKKTPSAKSVKVSTLNSAAIAALNAVGLKTKQLPDGHTAVYTANGQALGSINSVARALASLNGRTASTTITNTIITNSKTYRSVHDITKANGGIVNFADGGLTGRPAHRQHFANGTENHLAEIAPAGAWRIWAEDETGGEAYIPLALSKRRRSRAIAEETIRRLGGDPRTVQWNADGNVTDWRYDPTTGSLYSASDAGQAGHKTKKVKVKGKHGKTTTKEVDYFDVGAVEKKIKSAAKATTAWNKDLEKVADRAGGDVAEALAAMGEDGMKIAHKMATGSTKYINDMSKALRDLQKTAKASLTDYTRQLGSANTLNKKFSDNLAKLAAEGYGDLAQQLAAQNDEAAQQLADAAVKDPKKAGQANKAAKTANTALTADEVSELVSIIAAIKNPTTGIHQVAAATSLGEDEIISVANKAKGQISKSLGTRAVKFLADLGRANAHLSYADGGIRAGMYAAQGSIIRFAEPSTGGEAYLPLGAGKRSQAMPVLQDVARRFGVGLTDASGGRQVVIVRSGDTINVPVTAVRTGATASDIGSQVGRSYRRARRGGVAARAA
>CP032230|0:10694|8859_9273_-|QBJ94524.1|DBSCAN-SWA
MRRAEHHPDRPGKRLTQDARLRDELALCRQYQIPHSAFRGGDGTWTALDREKALAYENHLRGTCPQCGTRDSDWTDEAGEYQEAYIAVSHKCFGCEEIAAKQGEIPDGKAGAGMKVLLLPASVHAAQQALAELTSSR
>CP032230|0:10694|2675_3575_-|QBJ94419.1|DBSCAN-SWA
MPLSLNDWQYDIGGVIIGAGTPVQVIETTGLGRPPVRDNDVDQPSADGQFAGPDYWAGRQIQFDAAIRVPGDPAACHDVVAALQAATDGTAVRLVGGQGMTLRIKRPGRPVKSLTVRARKLDPEYKQVVHGYVPLDMEFLAHDPTFYADTDSTTEIPLGWLTGGGFAAPIAAPIFVQDGTVAADRPGWVTNAGTAPAWPVIRISGPCANVTVIHADSGRTLAMPTLNLAAGRWIEVDTRPGARTVTWDNGGNASTYLSPASRIDLFSLPPGQSEMRWTAFDNTNTARMRLTWRDAYTAL

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
QBJ94416.1|0_619_-	hypothetical protein	A0A249XNP1	Brevibacterium_phage	2.2e-16	32.0
QBJ94417.1|618_1731_-	hypothetical protein	A0A059VKH5	Mycobacterium_phage	6.4e-14	28.6
QBJ94418.1|1727_2663_-	hypothetical protein	A0A249XNP0	Brevibacterium_phage	2.0e-16	34.4
QBJ94419.1|2675_3575_-	hypothetical protein	A0A2D1G623	Propionibacterium_phage	8.8e-06	27.8
QBJ94420.1|3564_8826_-|tail	phage tail tape measure protein	A0A068F1L4	Mycobacterium_phage	4.3e-44	32.3
QBJ94524.1|8859_9273_-	hypothetical protein	NA	NA	NA	NA
QBJ94421.1|9227_9782_-	hypothetical protein	NA	NA	NA	NA
QBJ94422.1|9887_10694_-	hypothetical protein	A0A249XTY6	Mycobacterium_phage	6.9e-10	60.0