CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
LS483405	Lactobacillus brevis strain NCTC13768 genome assembly, chromosome: 1	2 crisprs	cas3,csa3,DEDDh,DinG	0	1	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: LS483405_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LS483405_1

124843-124997

Orphan

I-E,II-B

Consensus_repeat	Method
TAGTGTATTCCCCACATGTGTGGGGGTGATCCT	CRISPRCasFinder

2 spacers

The CRISPR arrays of LS483405_1

>merge|LS483405|1|124843-124997|CRISPRCasFinder
TAGTGTATTCCCCACATGTGTGGGGGTGATCCTCGTGGATTATATCACACCGATTCCCGAATAGTGTATTCCCCACATGTGTGGGGGTGATCCTAAGTCAGTGCTTAAGCCTATCCATTATGCAGCGTATTCCCCACATATGTGAGGGTGAACGG

>LS483405|1|1|124843-124997|CRISPRCasFinder
TAGTGTATTCCCCACATGTGTGGGGGTGATCCT	CGTGGATTATATCACACCGATTCCCGAA
TAGTGTATTCCCCACATGTGTGGGGGTGATCCT	AAGTCAGTGCTTAAGCCTATCCATTATG
CAGCGTATTCCCCACATATGTGAGGGTGAACGG

Protein	Signature genes	Signature genes Name	Protein_function
LS483405.1\|SQG74534.1\|127488_128331_-\|Aryl-alcohol-dehydrogenase-related-enzyme	unknown	unknown	gnl\|CDD\|381314
LS483405.1\|SQG74530.1\|125314_125890_+\|Transcription-regulator	unknown	unknown	gnl\|CDD\|224228
LS483405.1\|SQG74550.1\|135556_136303_-\|nitroreductase	unknown	unknown	gnl\|CDD\|380322
LS483405.1\|SQG74509.1\|115884_116148_+\|Uncharacterised-protein	unknown	unknown	unknown
LS483405.1\|SQG74547.1\|134748_135408_+\|mycofactocin-system-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224228
LS483405.1\|SQG74516.1\|118754_119183_-\|uncharacterized-HTH-type-transcriptional-regulator-yybA	unknown	unknown	gnl\|CDD\|224759
LS483405.1\|SQG74523.1\|121740_123228_-\|glucose-6-phosphate-1-dehydrogenase	unknown	unknown	gnl\|CDD\|235579
LS483405.1\|SQG74545.1\|133114_134584_-\|drug:H(+)-antiporter	unknown	unknown	gnl\|CDD\|341045
LS483405.1\|SQG74532.1\|125959_127387_+\|coniferyl-aldehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|143451
LS483405.1\|SQG74525.1\|123688_124510_+\|aminoglycoside-N3'-acetyltransferase	unknown	unknown	gnl\|CDD\|376807
LS483405.1\|SQG74518.1\|119267_119705_+\|acetyltransferase	unknown	unknown	gnl\|CDD\|225064
LS483405.1\|SQG74543.1\|132396_133011_-\|NADH-flavin-reductase	unknown	unknown	gnl\|CDD\|225462
LS483405.1\|SQG74536.1\|128570_129386_+\|Extracellular-protein	unknown	unknown	gnl\|CDD\|235640
LS483405.1\|SQG74506.1\|115158_115752_+\|Uncharacterised-protein	unknown	unknown	unknown
LS483405.1\|SQG74541.1\|130959_132306_+\|glycerol-3-phosphatase-transporter	unknown	unknown	gnl\|CDD\|340903
LS483405.1\|SQG74504.1\|114832_115144_+\|Uncharacterized-protein-conserved-in-bacteria	unknown	unknown	gnl\|CDD\|370809
LS483405.1\|SQG74514.1\|117167_118610_-\|6-phosphogluconate-dehydrogenase,-decarboxylating	unknown	unknown	gnl\|CDD\|236453
LS483405.1\|SQG74538.1\|129635_130802_+\|major-facilitator-superfamily-permease	unknown	unknown	gnl\|CDD\|340887
LS483405.1\|SQG74521.1\|119788_121522_-\|lipoprotein	unknown	unknown	gnl\|CDD\|372109
LS483405.1\|SQG74511.1\|116365_117001_-\|Uncharacterised-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
LS483405.1\|SQG74534.1\|127488_128331_-\|Aryl-alcohol-dehydrogenase-related-enzyme	gnl\|CDD\|381314	cd19088, AKR_AKR13B1, AKR13B family of aldo-keto reductase (AKR). Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.	2.34671e-134
LS483405.1\|SQG74530.1\|125314_125890_+\|Transcription-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	1.98151e-10
LS483405.1\|SQG74547.1\|134748_135408_+\|mycofactocin-system-transcriptional-regulator	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	4.61549e-09
LS483405.1\|SQG74516.1\|118754_119183_-\|uncharacterized-HTH-type-transcriptional-regulator-yybA	gnl\|CDD\|224759	COG1846, MarR, Transcriptional regulators [Transcription].	5.23633e-15
LS483405.1\|SQG74523.1\|121740_123228_-\|glucose-6-phosphate-1-dehydrogenase	gnl\|CDD\|235579	PRK05722, PRK05722, glucose-6-phosphate 1-dehydrogenase; Validated.	0
LS483405.1\|SQG74550.1\|135556_136303_-\|nitroreductase	gnl\|CDD\|380322	cd02146, NfsA-like, nitroreductase similar to Escherichia coli NfsA. This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.	1.05595e-79
LS483405.1\|SQG74532.1\|125959_127387_+\|coniferyl-aldehyde-dehydrogenase	gnl\|CDD\|143451	cd07133, ALDH_CALDH_CalB, Coniferyl aldehyde dehydrogenase-like. Coniferyl aldehyde dehydrogenase (CALDH, EC=1.2.1.68) of Pseudomonas sp. strain HR199 (CalB) which catalyzes the NAD+-dependent oxidation of coniferyl aldehyde to ferulic acid, and similar sequences, are present in this CD.	0
LS483405.1\|SQG74525.1\|123688_124510_+\|aminoglycoside-N3'-acetyltransferase	gnl\|CDD\|376807	pfam02522, Antibiotic_NAT, Aminoglycoside 3-N-acetyltransferase. This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyze the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic. The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.	3.04712e-82
LS483405.1\|SQG74518.1\|119267_119705_+\|acetyltransferase	gnl\|CDD\|225064	COG2153, ElaA, Predicted acyltransferase [General function prediction only].	1.98458e-34
LS483405.1\|SQG74543.1\|132396_133011_-\|NADH-flavin-reductase	gnl\|CDD\|225462	COG2910, COG2910, Putative NADH-flavin reductase [General function prediction only].	1.5499e-53
LS483405.1\|SQG74536.1\|128570_129386_+\|Extracellular-protein	gnl\|CDD\|235640	PRK05901, PRK05901, RNA polymerase sigma factor; Provisional.	0.00230747
LS483405.1\|SQG74541.1\|130959_132306_+\|glycerol-3-phosphatase-transporter	gnl\|CDD\|340903	cd17345, MFS_GlpT, Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters. Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.09754e-142
LS483405.1\|SQG74504.1\|114832_115144_+\|Uncharacterized-protein-conserved-in-bacteria	gnl\|CDD\|370809	pfam10078, DUF2316, Uncharacterized protein conserved in bacteria (DUF2316). Members of this family of hypothetical bacterial proteins have no known function.	1.18782e-41
LS483405.1\|SQG74514.1\|117167_118610_-\|6-phosphogluconate-dehydrogenase,-decarboxylating	gnl\|CDD\|236453	PRK09287, PRK09287, NADP-dependent phosphogluconate dehydrogenase.	0
LS483405.1\|SQG74538.1\|129635_130802_+\|major-facilitator-superfamily-permease	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.26943e-63
LS483405.1\|SQG74521.1\|119788_121522_-\|lipoprotein	gnl\|CDD\|372109	pfam12440, MAGE_N, Melanoma associated antigen family N terminal. This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumor rejection antigens which are expressed on HLA-A1 of tumor cells and they are recognized by cytotoxic T lymphocytes (CTLs).	4.58198e-05
LS483405.1\|SQG74545.1\|133114_134584_-\|drug:H(+)-antiporter	gnl\|CDD\|341045	cd17502, MFS_Azr1_MDR_like, Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.21799e-55

>LS483405.1|SQG74525.1|123688_124510_+|aminoglycoside-N3'-acetyltransferase
MTNWQEREITRVTTAIDLYDLFDRLGLRATDSCLVHTSLSAFGYIPGGEQTLVTALKTTLSQGNIVMPAQSADYTDPREWLYPPVRQDLQAKVMAGMPAYDRTLTPCHFIGITPEYFRTLPDTQRSGHPTCSMTAWGRNAAQICATPTLDLPFGAQGPLQKLYDLNAKVVCLGTDFETATAIHLAESIIGRPVFEEQAPISVAGKPQWRSYQMVELEPYDDFNVMGAAFCQAHPEQVVQQPLGQHHQARAIGMRTLVDFAREYYREKDRREMS
>LS483405.1|SQG74523.1|121740_123228_-|glucose-6-phosphate-1-dehydrogenase
MATERTALFMFFGGTGDLAYRKLYPSLFNLYRKGNLRTHFAVIGTSRQSIDDDKFRAAVKKSLADSGNRADSKEASDFISHFYYQSHDVTDTAHYSVLKELAEKLDKKYKLQGNRIFYLSMAPQFFGTIAQDLKTQGLMSTDKDAFNRLVIEKPFGRDFDSAKQLNDALSKSFEEEQIFRIDHYLGKEMIQNIEALRFGNTLVESLWNNRYIDNIQVTLSEKLGVEERASYYDNSGALRDMVQNHIMQIVSLLAMEQPVAFTDTDIRAEKVKALRSLRVYNVADAATNFVRGQYGSVNDQPDYRHEDNVPVDSTTETFVAGKLLFDNYRWSGTPFYVRTGKMLADKFTRVDVVFKRPLVDIFAFPQSQNTPLAANVLTIFVEPHAGFSLQLNAKTNDTGFQTEPIKLDYIVGAEKSKDTPEPYERLIHDVLKGDGTNFSSWPEVSYAWKFVDQIRRVWDLQEPNFPNYTPHSMGPAAAEELIQRDHREWIYRLNN
>LS483405.1|SQG74521.1|119788_121522_-|lipoprotein
MTFSPLNVPILLLSTSLLTLTLANVQPVTAHATATSVSLAEKTTTSTATAQLFTSPVNQPLTLTADTYPLYNNEGQETTDTLPGKQQLTTTKILVDPLAGTTYYRVQENPDRFIKYDATTVNLKHTLTLNFFNTSGGLIANPVSFRMTQGNDFDAIASDLKDQYAAVIDGFVFNKTTVDNTTDPYNTQFNFSYDKAGSSSTDESHTSIPASSLPSLSTLTNEKIRLTSPNDYSLYDNGGNNLTTGKTTVAGSSYYSATGLYLFHQKLTNADNVFYQISPDAFIKGDNTTALTSPITFKYETSDGQSIKTDSMLDTGLVTGDDLNNLIKELQTWQPTIDGYTYQSVNPTADTLTFKYTPTSTSSSSDTSSPSSDSSQSSSSTSTDSTASSSQTSSSTSTDSTASSDTHNSVVTSASSTRPDKSIVPKGAAVTAIRKIGVYRDVQFTKQNRRHWYQRQPQTKRPQFVVTGYARTKAGTLRYQIRGVNHHSATDGQRGYITANSKFVMPTYYQAAPKRIKVISPHGVNAYRQINLTQKKRHYRVGTTITVKAIKSYHLTTRLVLSNGTYVTANKILVAKK
>LS483405.1|SQG74518.1|119267_119705_+|acetyltransferase
MEWQAKSFDELSREEFFDIAYERIRTFVIAQHRPYQEIDATDKVARHILGYQAGQLVAYARVFREAGHVTFGRVLTIPEQRGTGLGRQLMVQIEAEIRRNFAGEAISIEAQIDKQHFYEKFGYAAIGAVFDFNGTPHIRMDKAGL
>LS483405.1|SQG74516.1|118754_119183_-|uncharacterized-HTH-type-transcriptional-regulator-yybA
MPNAFRSIGLIARATAAMGNKLFQADDLNNNQFIFLMRIVETPGITQAELATQLHVDPSTCLRAVRKLIATQYVTRGTDAHDKKRRPLLATAKGQAMYPALEDYEQQILSVGTQGLSTGETALLEELLAKVARNVRDYQNQH
>LS483405.1|SQG74514.1|117167_118610_-|6-phosphogluconate-dehydrogenase,-decarboxylating
MADQKANIGVVGMAVMGKNLALNIESRGYTVGIYNRSANKTEQVMKDHSEKKLVPSYTVEDFVKSLETPRRILLMVKAGKPTDAVIHELLPLLDKGDVLIDGGNTNFHDTMARNAELDKSGINFIGMGVSGGELGALQGPSLMPGGQKEAYDLVAPILEKIAAKAPQDGKPCVTYIGPNGAGHYVKMVHNGIEYGDEELIDESYNIMRNVAGISVDDMADIFKEWNKGELDSYLIEITADILTRKDDLGDDKNLPIVDAIKDRGNNKGTGKWSSEDALDVQVPQSVITESVYARYISMLKDERVKASKVLPAAEKQGKADIADKDKFVEEVRQALFFGKLMSYAQGFEQLRFASEANDWDLKFGELAQIWRGGCIIRAQFLQNITDAFDKDPKLSNLLFDDYFKDIAGKYQQSIRDVVAMAVQAGIPVPSLSAAITYYDSFRAEVLPANLLQAQRDYFGAHTYERNDREGNFHYSWYEEQ
>LS483405.1|SQG74511.1|116365_117001_-|Uncharacterised-protein
MKQLLLRSTLTILFYGIWVIWLWRLDHVFMIDDSPAIWEAIGLLLSGIGLLLWIVWSLAHWKQDPELGLSGLLLLLLLPVIGILRGQLAPVIPLLSIITFWLLAGVCLGHPAKDRSLGWLLGGTVVLSLLCLLTPSTSARLYLAGYRSPAVAMRTQLSGDQYHQITTYKFSHPDTTEVQLVGSATDPFLSVDVHQVGCLYLPVEDKWWIGG
>LS483405.1|SQG74509.1|115884_116148_+|Uncharacterised-protein
MTENVVLAPPEALELAKHLDEWAKWRQTHDRTTADMDWDQFIAKSREKAQWQAGLATEIDHWESLHAIQLALTDNLMGTAHGGHTRQ
>LS483405.1|SQG74506.1|115158_115752_+|Uncharacterised-protein
MSRGEDIAEISELVARERLFRARHNPAIADCYYPDATVATSWQQGPLSTFLNAESTEVDPRFAIVGNNSGAVVHLNGRRAYVELPTCTHMRMMVNGTLAQIESYRRLLYRVEKRTTDWKISQMTSINENDDLRPVIAGQDLHINPQDLVGLRPSYQFLAYVRQAAGGKISANLLGTDRPADVDQLYAEAENWLRQTK
>LS483405.1|SQG74504.1|114832_115144_+|Uncharacterized-protein-conserved-in-bacteria
MSLNAQQLVATRQELHANFILTGLTKEQVAADLHISLTKLDHLFTLTQQSLNDPWILRNYLLERVVATGQDPVPFTALSGDWHRHWFLDSEVIDRREMSAGDR
>LS483405.1|SQG74530.1|125314_125890_+|Transcription-regulator
MREKDTAKQTSIIDEVSNIILNEGIAAVSMSKIAKASGISSSTIYVYFTDKEDVLKQVYLAKKEMLATFLLKNIEATTDNPVIFAQQFMRALYEFGMQHYEALMIIEQFNSSPVRNNLQISQAESYRGFERLFEATSHAPQFVTDSAAVILGFAYAPIVLYVKARKTNQLAAQTISIEQVIDMCMHALLKE
>LS483405.1|SQG74532.1|125959_127387_+|coniferyl-aldehyde-dehydrogenase
MTTNVEMTKIFEDQRQQYNRAQPMSLATRLTTLDQLERLLRENLNAFVEALQADFDQRDPLQIIGADLTGPLTTIAYTRKHLRKWMKPDKKRLGLMGLSGGREYVYNEPLGVVGIMSPFNAPIDLALDPAIEAIAAGNRVMVKISEYTPKAAALLQKLAKKYVSETTFAVITGEADVSVHFSALNWDKFVFTGGSETGKKILAAAAPNLTPVVLELGGKNPAVVLPDANQQLAAEKIARGRSGNSGQICLDVDYAMVPANQLTDYIHLIVEQLEQAFPTYSDNPEYSAIINDAAYKRITGMLAEAQQRGTQLLTINPNHDAVPDATKRLIPLTLAINPDPDLQIAKNEIFGPILSIFTYETLDEAIAFINTHEKSLAMYVFGKNKAQLDRVIRHTSSGGVDINELALHAGSHEMGFGGVGYSGMGRYKGGKVGFETFSNPKSIYKQGILAKYTTRFMVPIHSQRNEKRFKKMLGL
>LS483405.1|SQG74534.1|127488_128331_-|Aryl-alcohol-dehydrogenase-related-enzyme
MEKTFTFDSDLTVNRLGYGTMQLTGDGVWGPVADPDNAVKVIETAIDHGVNFIDTADAYGPFYANLYLRDALKNRPDNHVMVATKVGNTRQGPDVWTPVGVPAYLRQQVEMNLFTLGLDHIDLLQLHRVDPNVPLADQIGVLKDMQDEGKIKHIGLSQVSVDQLKEATAIAPIVSVQNMYNLSNRQDEDVLDYADAHHIAFIPWFPLATGELIKDATLTNIAQKYNASPAQIALAWLLKRSDVILPIPGTKSSDHELQNIQAQDIDLSQADFDALKALAK
>LS483405.1|SQG74536.1|128570_129386_+|Extracellular-protein
MKKFMVALTGLVTLATVGATVPATAVTTAHAATKSTYVSPSLKVNAIYTTSTKVAGTATKGSKITVKATKNAKTNLASGTASKTTGKYSIKLSKKLKKNANVYVYATNSKTKAYFYRIIRVQAASTKAATTKSTSTKKTTTKKTTTKKSTTSSKTSAASFSVKTPTGTWTSNTANKYSQKWVFSQKTGLNEYLYKNGKKVKTLVSYAKYSVSAKTPTFWKITYTPKGSKTKQTMYLRFTSAKKFKVVNSKNQVISTKAGVAPAAKWAFTKA
>LS483405.1|SQG74538.1|129635_130802_+|major-facilitator-superfamily-permease
MWKTKKEVSLVGILSATLLLNAAAACMWPLTTVYMHNQLHQTLALAGVALLGMSLCMIVGNWLGGWLFDNWSPFKSALVGTLCSFIPMLTLIVFHGWPIFGIMLLFIGLGDGIVMTVVNSFAANIKEISSRRVFNWLYIGMNLGVVVGTLMVGMLMDHGVQLVFMVASLSYAALLVIFVVDFRMDIQTKTHQHVKGPAKPAQLQLIWLIAAMVFCLYLSYSLWESVISVHMTNLGISFEKYSLLWTLNGLLIVFGQPLANRIGTYFKMSSQIAVGTLIFILSFLLLVFARDYTMFVVTMVILTVGEMTGFPGIPAWIDGLAGDNDKGKFQGIYNMAISFGRAVGPLYGGLIIEYGSYQLLFWSVTGLMLAALAAVMLRNHHNLTRVKK
>LS483405.1|SQG74541.1|130959_132306_+|glycerol-3-phosphatase-transporter
MFSFLKPAPDAKVKVPAEKVVGTYRLRQTGVLLSICIGYIGYYIIRLIFTTEQNDIMKAYGFTTADIGLVMSCFGIGYGISKLFMGALSDKSNPKWYLATGLFISAILNFGLGSTRNLYVMMLLMLVMSVAQGMGAAACQRTVQLWWGKKWRGTVYAVWSSAHNAGAFACVAVVQIATLMFTHSIAAVFYTASVVSIVIAIFIVLAGADRPATVGLPSIGEYTGDEVVLDDGQATRAELTDLSLWQIFVRYILTNKVVWAITLTSMSLYLVRYGIMSWIPSYLTQFKGFDPGTAKWLVGIFELAAVPGVILMGAISDLLKDRRAIVCIGCVIGLLICLTTYFFSTSHLAIIIVLLIMGSLIYAPLTLVGLMVNESVPKFAVGSSTGFMGFFQYIFGETLATALIGILVAKFGWIASNTVLYTAAGLALLLLCYIAIHEHHVAKIAAGE
>LS483405.1|SQG74543.1|132396_133011_-|NADH-flavin-reductase
MKLAIIGATGKTGNAVLEVARTRKITVTAVVRNAAKLTEPVSVIEKDIFALTPADLQGFDVVICAFASSKKSDYPRVNQHLVEILTGTDTRLIVVGSGATLFTDETRQKTVGDELPLIMRNSSRKHLQARQILQASRLNWTYMAPPMNYVPDGNATGSYQVGHDVLLYDRHGDSTISYADMALALVDEVEHPQNERQLMTVAWK
>LS483405.1|SQG74545.1|133114_134584_-|drug:H(+)-antiporter
MTETRRRIITFGLLLANIMAGFEGTIISTAMPTIVADLHGLSLMNWGFTIYFLFNAIGTPIWGRVADIIGRKRSFLFGTAIFVIGSLLEGLATNMIWLIIARGIMGIGAGGMLAIPFIIFSEIYPVDQRASVFGFTAAFGGISAVCGPLLGGWIIDVLNWHWVFFINIPIGIISILIVYFAFREESKERHAKIDVWGSLSLSIVILAFLLGIQLIGQSHTPVIWAIAFLLVAIVFGFLFVRIERNTHDPLIPLHLFKNKDMLLWDLMAFVGMGFYISFSVYIPMWAQGILLTSALAGGATQIPTAGLWYSGSRFGSYLSKKRNHHLTAVLALSFALIGTLVLLALGMTPNYAFFIIVGALLGIALGMLLTTSQVGVSEAVTSNDLAVATTLNRLFNTLGQTIMTAIYGLVFNIVVNHQATKLGLPSAKISGLTNSAVTSDSKAQLLIMHHVLFAGIKSVLIVAFVLLLVALILEIGNIYLTRIKKQSVQ
>LS483405.1|SQG74547.1|134748_135408_+|mycofactocin-system-transcriptional-regulator
MATENERRQQMIRRITQTIVQNGFADLKMEKIAKLMGVSRTKMYQYYSSKTAIMTDVVARYLEFMATRSVPQSVDAKTSVTNFPQVILNLANLIASSSQKFRRDLAQADEELSEQFEESYASWCHQVRDFLTNGVTNGAFNSSLQPELFLIQMEATVAALMQPRVLTQHKVVTQNVLREYLQMVITQVVAPKYRAQINLDAVEPDLEHLTLKYQQTLTK
>LS483405.1|SQG74550.1|135556_136303_-|nitroreductase
MNPTLTTLFNHRSIRQFTPEKLTTDEVATLITAAQHAATSTFSQQYSVISVTDPAKLAVLGDITGHHWLEKAGHYFVMVADQYRNQQLVPPTATTTTNLHSLDKLLAGVFDAAIATEAIVTAGESLNLGSTIMGSILNDAARVIDLLDLPKLTFPVLGLAIGHPTEHPEQKPRLPQDLMHFTNGYQALTADNARLAAYDQVIHDYYQQRGTHQRDETFSHHIVSEMSRDPQQRAGILQALQQQGFLTK

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Crispr_ID: LS483405_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LS483405_3

1127841-1127932

Orphan

I-E,II-B

Consensus_repeat	Method
TGTATTCCCCACGGGTGTGGGGGTGATCCTC	CRISPRCasFinder

1 spacers

The CRISPR arrays of LS483405_3

>merge|LS483405|3|1127841-1127932|CRISPRCasFinder
TGTATTCCCCACGGGTGTGGGGGTGATCCTCGTAATGAGCAAAAGGTCATGCTGAACCTGTTGTATTCCCCACGGGTGTGGGGGTGACCTCA

>LS483405|3|3|1127841-1127932|CRISPRCasFinder
TGTATTCCCCACGGGTGTGGGGGTGATCCTC	GTAATGAGCAAAAGGTCATGCTGAACCTGT
TGTATTCCCCACGGGTGTGGGGGTGACCTCA

Protein	Signature genes	Signature genes Name	Protein_function
LS483405.1\|SQG80838.1\|1131610_1131727_-\|Uncharacterised-protein	unknown	unknown	unknown
LS483405.1\|SQG80839.1\|1132042_1132633_+\|uncharacterized-protease-ydeA	unknown	unknown	gnl\|CDD\|153234
LS483405.1\|SQG80827.1\|1121457_1121943_-\|MarR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|197670
LS483405.1\|SQG80830.1\|1124125_1124572_-\|two-component-system-sensor-protein	unknown	unknown	gnl\|CDD\|378668
LS483405.1\|SQG80844.1\|1136900_1137551_+\|nitrobenzoate-reductase	unknown	unknown	gnl\|CDD\|380313
LS483405.1\|SQG80834.1\|1127319_1127631_+\|phage-protein	unknown	unknown	gnl\|CDD\|374224
LS483405.1\|SQG80842.1\|1134305_1135202_+\|Transcription-regulator	unknown	unknown	gnl\|CDD\|223656
LS483405.1\|SQG80840.1\|1132645_1132999_+\|MmcQ-protein	unknown	unknown	gnl\|CDD\|225197
LS483405.1\|SQG80831.1\|1124568_1125015_-\|response-regulator	unknown	unknown	gnl\|CDD\|197918
LS483405.1\|SQG80835.1\|1127938_1129723_+\|Cna-protein-B-type-domain-containing-protein	unknown	unknown	gnl\|CDD\|375630
LS483405.1\|SQG80825.1\|1120118_1120955_+\|short-chain-dehydrogenase	unknown	unknown	gnl\|CDD\|181334
LS483405.1\|SQG80841.1\|1133098_1134187_-\|Aryl-alcohol-dehydrogenase	unknown	unknown	gnl\|CDD\|176239
LS483405.1\|SQG80833.1\|1125750_1127190_+\|EmrB/QacA-subfamily-drug-resistance-transporter	unknown	unknown	gnl\|CDD\|129794
LS483405.1\|SQG80836.1\|1129824_1130787_-\|peptidase-M10A-and-M12B-matrixin-and-adamalysin	unknown	unknown	gnl\|CDD\|365934
LS483405.1\|SQG80826.1\|1120963_1121368_-\|transcriptional-regulator	unknown	unknown	gnl\|CDD\|133384
LS483405.1\|SQG80828.1\|1122051_1123485_+\|multidrug-efflux-transporter,-major-facilitator-superfamily-(MFS),-EmrB-family	unknown	unknown	gnl\|CDD\|129794
LS483405.1\|SQG80843.1\|1135744_1136767_+\|uncharacterized-oxidoreductase-YajO	unknown	unknown	gnl\|CDD\|381305
LS483405.1\|SQG80829.1\|1123471_1124065_+\|Oxidoreductase-(Putative)	unknown	unknown	gnl\|CDD\|377026
LS483405.1\|SQG80837.1\|1131164_1131395_-\|Uncharacterised-protein	unknown	unknown	unknown
LS483405.1\|SQG80832.1\|1125176_1125629_-\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133380

Protein	Function_ID	Function_description	E-value
LS483405.1\|SQG80839.1\|1132042_1132633_+\|uncharacterized-protease-ydeA	gnl\|CDD\|153234	cd03140, GATase1_PfpI_3, Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus. PfpI is an ATP-independent intracellular proteases which may hydrolyze small peptides to provide a nutritional source. Only Cys of the catalytic triad typical of GATase1 domains is conserved in this group. This Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.	5.92809e-62
LS483405.1\|SQG80827.1\|1121457_1121943_-\|MarR-family-transcriptional-regulator	gnl\|CDD\|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	9.4244e-09
LS483405.1\|SQG80830.1\|1124125_1124572_-\|two-component-system-sensor-protein	gnl\|CDD\|378668	pfam11457, DUF3021, Protein of unknown function (DUF3021). This is a bacterial family of uncharacterized proteins.	3.62874e-27
LS483405.1\|SQG80844.1\|1136900_1137551_+\|nitrobenzoate-reductase	gnl\|CDD\|380313	cd02136, PnbA_NfnB-like, nitroreductase similar to Mycobacterium smegmatis NfnB. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.	2.95681e-44
LS483405.1\|SQG80834.1\|1127319_1127631_+\|phage-protein	gnl\|CDD\|374224	pfam15919, HicB_lk_antitox, HicB_like antitoxin of bacterial toxin-antitoxin system. This is a family of HicB-like antitoxins.	1.83833e-05
LS483405.1\|SQG80842.1\|1134305_1135202_+\|Transcription-regulator	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	6.05575e-22
LS483405.1\|SQG80840.1\|1132645_1132999_+\|MmcQ-protein	gnl\|CDD\|225197	COG2315, MmcQ, Uncharacterized protein conserved in bacteria [Function unknown].	1.47301e-18
LS483405.1\|SQG80831.1\|1124568_1125015_-\|response-regulator	gnl\|CDD\|197918	smart00850, LytTR, LytTr DNA-binding domain. This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.	3.13323e-18
LS483405.1\|SQG80835.1\|1127938_1129723_+\|Cna-protein-B-type-domain-containing-protein	gnl\|CDD\|375630	pfam18202, TQ, T-Q ester bond containing domain. This domain is found in gram positive bacterial surface proteins. It contains a very unusual isopeptide bond between a conserved N-terminal threonine residue on the first beta strand of the Ig-like fold and and a glutamine residue in the final strand of the domain.	0.000967542
LS483405.1\|SQG80825.1\|1120118_1120955_+\|short-chain-dehydrogenase	gnl\|CDD\|181334	PRK08263, PRK08263, short chain dehydrogenase; Provisional.	5.92329e-88
LS483405.1\|SQG80841.1\|1133098_1134187_-\|Aryl-alcohol-dehydrogenase	gnl\|CDD\|176239	cd08278, benzyl_alcohol_DH, Benzyl alcohol dehydrogenase. Benzyl alcohol dehydrogenase is similar to liver alcohol dehydrogenase, but has some amino acid substitutions near the active site, which may determine the enzyme's specificity of oxidizing aromatic substrates. Also known as aryl-alcohol dehydrogenases, they catalyze the conversion of an aromatic alcohol + NAD+ to an aromatic aldehyde + NADH + H+. NAD(P)(H)-dependent oxidoreductases are the major enzymes in the interconversion of alcohols and aldehydes, or ketones. Alcohol dehydrogenase in the liver converts ethanol and NAD+ to acetaldehyde and NADH, while in yeast and some other microorganisms ADH catalyzes the conversion acetaldehyde to ethanol in alcoholic fermentation. ADH is a member of the medium chain alcohol dehydrogenase family (MDR), which has a NAD(P)(H)-binding domain in a Rossmann fold of a beta-alpha form. The NAD(H)-binding region is comprised of 2 structurally similar halves, each of which contacts a mononucleotide. A GxGxxG motif after the first mononucleotide contact half allows the close contact of the coenzyme with the ADH backbone. The N-terminal catalytic domain has a distant homology to GroES. These proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and have 2 tightly bound zinc atoms per subunit, a catalytic zinc at the active site and a structural zinc in a lobe of the catalytic domain. NAD(H) binding occurs in the cleft between the catalytic and coenzyme-binding domains at the active site, and coenzyme binding induces a conformational closing of this cleft. Coenzyme binding typically precedes and contributes to substrate binding. In human ADH catalysis, the zinc ion helps coordinate the alcohol, followed by deprotonation of a histidine, the ribose of NAD, a serine, then the alcohol, which allows the transfer of a hydride to NAD+, creating NADH and a zinc-bound aldehyde or ketone. In yeast and some bacteria, the active site zinc binds an aldehyde, polarizing it, and leading to the reverse reaction.	0
LS483405.1\|SQG80833.1\|1125750_1127190_+\|EmrB/QacA-subfamily-drug-resistance-transporter	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.20799e-89
LS483405.1\|SQG80836.1\|1129824_1130787_-\|peptidase-M10A-and-M12B-matrixin-and-adamalysin	gnl\|CDD\|365934	pfam00188, CAP, Cysteine-rich secretory protein family. This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organisms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumor suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how the cysteine-rich venom protein helothermine blocks the Ca++ transporting ryanodine receptors.	4.18016e-13
LS483405.1\|SQG80826.1\|1120963_1121368_-\|transcriptional-regulator	gnl\|CDD\|133384	cd01109, HTH_YyaN, Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB. Putative helix-turn-helix (HTH) MerR-like transcription regulators of Bacillus subtilis, YyaN and YraB, and related proteins; N-terminal domain. Based on sequence similarity, these proteins are predicted to function as transcription regulators that mediate responses to stress in eubacteria. They belong to the MerR superfamily of transcription regulators that promote transcription of various stress regulons by reconfiguring the operator sequence located between the -35 and -10 promoter elements. A typical MerR regulator is comprised of distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their N-terminal domains are homologous and contain a DNA-binding winged HTH motif, while the C-terminal domains are often dissimilar and bind specific coactivator molecules such as metal ions, drugs, and organic substrates.	3.12944e-44
LS483405.1\|SQG80828.1\|1122051_1123485_+\|multidrug-efflux-transporter,-major-facilitator-superfamily-(MFS),-EmrB-family	gnl\|CDD\|129794	TIGR00711, Uncharacterized_MFS-type_transporter_YhcA, drug resistance transporter, EmrB/QacA subfamily. This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other].	1.96679e-46
LS483405.1\|SQG80843.1\|1135744_1136767_+\|uncharacterized-oxidoreductase-YajO	gnl\|CDD\|381305	cd19079, AKR_EcYajO-like, Escherichia coli YajO and similar proteins. Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.	4.2019e-163
LS483405.1\|SQG80829.1\|1123471_1124065_+\|Oxidoreductase-(Putative)	gnl\|CDD\|377026	pfam03358, FMN_red, NADPH-dependent FMN reductase.	2.66358e-24
LS483405.1\|SQG80832.1\|1125176_1125629_-\|MerR-family-transcriptional-regulator	gnl\|CDD\|133380	cd01105, HTH_GlnR-like, Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators. Helix-turn-helix (HTH) transcription regulator GlnR and related proteins, N-terminal domain. The GlnR and TnrA (also known as ScgR) proteins have been shown to regulate expression of glutamine synthetase as well as several genes involved in nitrogen metabolism. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. A typical MerR regulator is comprised of two distinct domains that harbor the regulatory (effector-binding) site and the active (DNA-binding) site. Their conserved N-terminal domains contain predicted winged HTH motifs that mediate DNA binding, while the dissimilar C-terminal domains bind specific coactivator molecules.	3.35261e-20

>LS483405.1|SQG80834.1|1127319_1127631_+|phage-protein
MTKANIVTYPAVFHDNEAGGYIVTFPDIEEAMTSGQTLGESLVNATTVLGQTLHHHPMVLPTATTITELMHQYPMAFIQFVAVDLDQVIEHAVPTDQADLQLT
>LS483405.1|SQG80833.1|1125750_1127190_+|EmrB/QacA-subfamily-drug-resistance-transporter
MTTDITDKPYNRAMMVTILLIGTFLNVLNQTVLATAFPDLMKAFSINATTVQWLTTGFLLVNGIMIPLSAWLSTQFNSKWLWISAMTIFAGGTILCWAAPSFAMLLSGRLIQAVGVGVAMPLLQTIMFSIFPPEQRGSAMGLVGIAVGVGPAIGPTLAGFVVDNGSWRNIFGIMIPIAFVIILLSFFFMRPVIENRRTHLDVLSLILSSIGFGSVLYGFSTVGQNGWTDSTVITALAVGVIFVALFAVRQLTISEPFLELRVFAKGQFTVATILGAIANTAMTGAELVLPMYLQIVRGQSALISGLTLLPGAIVIALMNPITGRIVDRIGGRELSIIGLACLTLGTLPLCFLQSDTALWWIILVYAVRMLGVSMVLMPITTVGMNALDRSLIAHGTAVNNTVKQIFSSIGTALVVSIMANVTKGNMPNVRLYIKQPTLLHHLIMNANLDGYTAAFIVTAAMSFLGFLMAFLVKRSTKKA
>LS483405.1|SQG80832.1|1125176_1125629_-|MerR-family-transcriptional-regulator
MTVTDNFSNWLNLIQQVSQPEGITLGTSDLVKATGVPASQLRYWVEQGYIKPIDVPNERSRKFSYRVVFRVRAIKYFLDHGYTLSAAMDNVNQFRNLDIQLQRILTDHLTDLQLHEDGQIDISLGTVQDGQELLGLTIKDGSSQFWTKKV
>LS483405.1|SQG80831.1|1124568_1125015_-|response-regulator
MHVTFNLKASFIPPFITINAPAETPELQHLAANISQLTNSQLIAGISPRGTRELVPVNQIIRIHTDAKHVVMETKITTYTLPQRIYQLKQLLPSDLFLQLSSGELVNRQHIRHFSLTPSGLYQVLLSTGATTFVSRRCMQQIRKEFLK
>LS483405.1|SQG80830.1|1124125_1124572_-|two-component-system-sensor-protein
MKRLGILTSGAFLGLSIGFLCALFFSLTNHATTFMPSSPDFVAHFSSNTMATLAAAGLWATIGLLFGLTSLIFFNEHWSIARQTIWHFGLSYLGFTPLAILAGWFPLNVTWLLLYTLIFIGIYLVIWTYSMLRARKTVQHLNDTLSHH
>LS483405.1|SQG80829.1|1123471_1124065_+|Oxidoreductase-(Putative)
MMQINLVLGSSREKSLGRRVFNYLKNQQNDFEQQNAVHLNFIAVGDYQLPFFYEDVAPMNNQDRHLPAQQQAWLDDMEQASGYIFITPEYNHSFPAVLKNGLDYLAFQTAKKPALIMSYSDNARAGQFGGVDLTRLGMTVLPPLVGIGNVQKNFNEAGEFLVNAPSKDFYHQKLQQTVEKIAFYSRLFADNPFTPQS
>LS483405.1|SQG80828.1|1122051_1123485_+|multidrug-efflux-transporter,-major-facilitator-superfamily-(MFS),-EmrB-family
MKTQAIRWWVLACIGIMTFMDDLDASIVNVALPVINRALAINMGVAELIVSVYLITICVFLLPFGRLGDTFSKVRVFKWGMWLFVLGSLGCGLSPNIISLLLCRLIQGLGAAMTMSTNNGIITESFPINERGRALGWIGSFVALGMIAGPGIGGLLLSFLPWESIFWINVPIGLLLMGLGHAVLTTETGSDDRPVFDWLGSGLIGIGISGFFGYLYAGQQLGYGQPLLMGLLAVAMIATLVFILYEIKCQQPLLDLKIFRKTDFTVGVGTALLVFVANNFYMVLTPFYLENAKVIGASVAGLIMMILPVVQVLMAPIAGRIADNQGPFKLCLTGLLIILSAQIGFVLINQQTPLTLVGGLIGLLGLGNALFQSPNNALIMGAVEQTQLGVAGSVNALSRNIGMVLGNALATSLLFVIMSALTRSKVTNFDGHFKRAFITGQSWVYLLGSLLVLLAIGLVSFNTWKNKKMEALSDDAN
>LS483405.1|SQG80827.1|1121457_1121943_-|MarR-family-transcriptional-regulator
MISSANAKNLMACISQLLTQDTTVDQEKKWMLSQVATDTTLTATIKALRTADFHTIATISTLTPAYLKSLPEKTGLSQPTISRMMTRLSHHDLVEKYRTVTNSKDILVRLTPKGTQIAEIHAQLDQRILNNVAQVLEPYSQTEVTTTIQILQEIAKIDVNR
>LS483405.1|SQG80826.1|1120963_1121368_-|transcriptional-regulator
MEYTMSDVCQKFNLSEYTLRYYDKINLIPGVYRNEQNRRVFTEDAVGWLQFVIALRSTGMPIADVKKYIALTTTTDDSTIQARLTMLQKQAAKVDSQIADMHKQRQIIADKINHYQQAMKTAPDPTKKSYQRWV
>LS483405.1|SQG80825.1|1120118_1120955_+|short-chain-dehydrogenase
MTKTWFVTGSSRGLGRAIVENSLSNGDNVVATARNTASLADLATEYGEHIYPLSLDVTDVDAVDAAIQMAIQHFGTIDVLVNNAGFADMDSVEEMPLATFKAQMDTDFYGTLYTIRAVLPTMREAKSGRIINISSIGGRIGGAGLSAYQSAKFAVNGLSEVLAHEVQSFGIQVTTVEPGGMRTEWGGDSMKAASSDLYKDSVGQAISMIHDQWHHAGDRYVSEPDKVAAAIHTLSEMPQAPVHLLIGKDAEQAAQQNAETLAKNDMANRSLTESTGNR
>LS483405.1|SQG80835.1|1127938_1129723_+|Cna-protein-B-type-domain-containing-protein
MQQEDPSAHILHICRGGLNTGDGSSTGGNTDTGNGSSATGDDNSSSISVSISSNDSDEQIKQAVASLEKIAARYSLSTTALDNVVAKASDPMSATDKAEIVAAFSNVVSKIKDIQNSDQNTVDQNTGDNASDPNHANTGYTTNLSGTAAANKRLSENKLVPVKPDYDTTPINPHDKKYLIDTTGLRGQKMVMLEDMSTGQGTKEDQITSEVDVNNTKQTVRVTNPAIHTMQTVNNKKNFVLKGDGSNVQEPIVDKVSFTDFAPGEKMVLTAVEMDAGTQQPVILDNQYLIGRKSLTPTTSDGVATVQFNEFDGAPNARYMTPVLNSAGLVTNSVVNDGISSAQDSDNNSDAVNRDETNDEQADGSVTGAYQGVAGLGLGTDDTDAETDTTAYNINLQSLNSLAALSDGDQAKWVAYETAQSADGNVVAEHKDASDTGQTISITHNAGTTDNNAQGGLTVNNQNGQKQGNDGSLDSHNANNPSNGGSISNGSNPTNGSNPSNGGSLSNGSNPTTGSSTTPGSQYTTTQPGQNGTTTTQVPSQLPSQARSVFSQGQPLQGTTYVRPSVTRPTFGQTGGTDKLSNNWFYNFIYRFVK
>LS483405.1|SQG80836.1|1129824_1130787_-|peptidase-M10A-and-M12B-matrixin-and-adamalysin
MSTKAQKLLCIAFSALVGLSITAAVPTTSQAAKRKPGKVVRTMKYKTMKVKAKKGYVYTSTKLTKRGVHLTKYKNKTMTTKKAYLIKVPGKPAVWYDRVSSKNKKLNGYVYNNYLKVIKKTSTKGKTSTKSTNKVPVDPDANVPLKDLYSYGTNSKNNTTQKLGLDGDQSYFDTDVFSKYPANLDEFKSIFVELLNQERLSRGLSPVSVDSDLSKIADKRALDSQKINDLVHLDSAGNSIAAVYAKKAGLNVPPFSECLGFVENAPARMVARESLRDYIYQDAASDWGHRNILLNPSYTRIGVGITTAKNKMTVNAIEMY
>LS483405.1|SQG80837.1|1131164_1131395_-|Uncharacterised-protein
MNIEAAHNSVVLWENKTADLQEHIDGFCTILESHDDPEIKEMVQQAINEKARYNKELQKAQSDLDAAIGSILSSVH
>LS483405.1|SQG80838.1|1131610_1131727_-|Uncharacterised-protein
MFNFLKSFGNAIIVLSAIGAFEVIRFVITVVTTIAGLF
>LS483405.1|SQG80839.1|1132042_1132633_+|uncharacterized-protease-ydeA
MKQAIFIMMDHYADWEGAYLSSQLNQMADWVVKTASNQSEVTSIGGWTTLVDYQISELKPEMTLLVLIGGNAWQHDDPRLTALVQQCLQRKVIVGAICGAVDYLARNGLLTGYNHTGNAQFLWQSFPRYQNPTDFEPQQVVVDRQLVTANGTAALAFTSAVLKASGQLTTAAKQALDLQQLGYYEYTRQYGDPFKP
>LS483405.1|SQG80840.1|1132645_1132999_+|MmcQ-protein
MERTVIFQHVEDQYGIQPEYLWSKYPSYAILRQPQNHKWFAILMDVSADKLGLLTEQSVPIMVIKLEPEAVESLQADPAFLPAYHMNKSHWVSARLDQISTEESYRLLEHSYTLVSG
>LS483405.1|SQG80841.1|1133098_1134187_-|Aryl-alcohol-dehydrogenase
MQIKTAFSDGTSGQLKIIDATLDEPKANEVLIKMVATGVCHTDTAGRDGLTTPLPVSLGHEGAGIVEQVGSSVMDLQPGDHVVLSFAYCGRCQHCLTGHPGMCEHFNELNFAGHNFDGSHRIHTLDGQPISTFFGQSSFSTHAVVDQHNVIKVDPTVDLRLLGPLGCGIQTGAGTVLNYLQPKFGESLVIFGTGAVGLSAIMAAKITGANHIIAIDIFDNRLALAKELGATEVINSHQADVEATLKEILPTGADYTIDTTGVSPVVMNALHALKPGGECAVVGMGRDLTFNLMNDLMAEGKKISGVIEGDAIPQLFIPKLVDYYKKGRFPFDKLIKFYDFDQINDGFAASKDGSVLKPVVTF
>LS483405.1|SQG80842.1|1134305_1135202_+|Transcription-regulator
MEERQLILFVETVQLGSFQKTAELNLMSQRAVSKRISALETEIGATLFDRQKNKINLTAAGKHFLTRATELLNTMRMTTYEVQQITQQAKEQFSVGYFSPFEGALLRMALLDLPTTTNFLIEEAGIEHLISDVLLKKIDCAVIIDNPLFNAKIDQTNLDSVTLVTDHMTLGISPDLITDQTDSPADYLAKFPVIYYSSEESTYLEEVFKSSIGQFADTFSARRVNSYEQMQLLVGMGKAISFYPTELIKYMATPYDHITYLSLDGVTTAHSEFKLIYHHNNHQPLIKQIQRYFDNHQF
>LS483405.1|SQG80843.1|1135744_1136767_+|uncharacterized-oxidoreductase-YajO
MTQTSMQYTKLGHTEIMASKICVGAMSFGQPGTMHDWTLDYPASERVIGHALSLGINFFDTANGYSAGTSETYLGRALKAQRVARDQVVLASKVYFNPGRLSAKAIHHEIDGTLKRLGTDYLDLYIIHRFDYDTPIEETMAALNELVTAGKVRAIGASAMYGYQFNNMQQVAKDRGWAQFQTMENHYNLLYREDERELIPICQQQGVSLMPYSPLAAGHLSHSAWQVDTLRSQTDRVAMGKYDRTETEDQRIVARVAELAHKYQVSMTQIALAWQWAKGVAAPIVGSTKTSHLDEAVAALSVKLTTADIDYLEDLYRPHPIVGALDHNPAAGTILIDQKK
>LS483405.1|SQG80844.1|1136900_1137551_+|nitrobenzoate-reductase
MDVLEAIKDRHATRAFDDKAIDDQNLTAIVTDAQRTPSWGNSQPWEVYIATGKSLEQIKSRYAAAAQAGVTEAADLAKAHRGDFSTMANQNMGHWVGTFRPIIEADQTTYWDSRENLYRAPAIAYLVLGQNPNSWSIYDLGAFSQTLSLAATARGVQSLSSYELVKYPDILRQELAVPTDRTIAMGIALGYEKPDKVLNQFRTDRVATQQILHIQH

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	MN830254	Lactobacillus phage JNU_P2, complete genome	42714-42743	4	0.867
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	MN830255	Lactobacillus phage JNU_P4, complete genome	29237-29266	4	0.867
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	NZ_CP036260	Sporomusa termitida strain DSM 4440 plasmid pSPTER, complete sequence	59572-59601	7	0.767
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	NZ_LR135244	Enterococcus faecium isolate E6988 plasmid 2	136721-136750	7	0.767
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	NZ_LR135255	Enterococcus faecium isolate E7098 plasmid 2	116474-116503	7	0.767
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	NC_015963	UNVERIFIED_ORG: Enterobacter soli plasmid pENTAS01, complete sequence	39067-39096	7	0.767
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	MG945601	UNVERIFIED: Microviridae sp. isolate 4418-1801, complete genome	4149-4178	7	0.767
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	MG945777	UNVERIFIED: Microviridae sp. isolate 3995-1801, complete genome	4165-4194	7	0.767
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	NZ_CP030091	Lactobacillus reuteri strain YSJL-12 plasmid unnamed2, complete sequence	9293-9322	8	0.733
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	NC_012586	Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence	1642761-1642790	8	0.733
LS483405_3	3.1\|1127872\|30\|LS483405\|CRISPRCasFinder	1127872-1127901	30	MH319722	Marine virus AG-345-D19 Ga0172267_103 genomic sequence	11330-11359	8	0.733

1. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to MN830254 (Lactobacillus phage JNU_P2, complete genome) position: , mismatch: 4, identity: 0.867

gtaatgagcaaaaggtcatgctgaacctgt	CRISPR spacer
gcaatgagcaaaaggtcatgctgaacttaa	Protospacer
*.************************.*.

2. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to MN830255 (Lactobacillus phage JNU_P4, complete genome) position: , mismatch: 4, identity: 0.867

gtaatgagcaaaaggtcatgctgaacctgt	CRISPR spacer
gcaatgagcaaaaggtcatgctgaacttaa	Protospacer
*.************************.*.

3. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to NZ_CP036260 (Sporomusa termitida strain DSM 4440 plasmid pSPTER, complete sequence) position: , mismatch: 7, identity: 0.767

gtaatga-gcaaaaggtcatgctgaacctgt	CRISPR spacer
-cagcgatccaaaaggccatgctgaacctga	Protospacer
 .*..**  *******.*************

4. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to NZ_LR135244 (Enterococcus faecium isolate E6988 plasmid 2) position: , mismatch: 7, identity: 0.767

gtaatgagcaaaaggtcatgctgaacctgt	CRISPR spacer
gaaaggagcaaaaagtcatgctgaaatact	Protospacer
* ** ********.*********** .  *

5. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to NZ_LR135255 (Enterococcus faecium isolate E7098 plasmid 2) position: , mismatch: 7, identity: 0.767

gtaatgagcaaaaggtcatgctgaacctgt	CRISPR spacer
gaaaggagcaaaaagtcatgctgaaatact	Protospacer
* ** ********.*********** .  *

6. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to NC_015963 (UNVERIFIED_ORG: Enterobacter soli plasmid pENTAS01, complete sequence) position: , mismatch: 7, identity: 0.767

gtaatgagcaaaaggtcatgctgaacctgt	CRISPR spacer
aagaagaaaaaaaggtcatgctgagcctgt	Protospacer
. .* **. ***************.*****

7. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to MG945601 (UNVERIFIED: Microviridae sp. isolate 4418-1801, complete genome) position: , mismatch: 7, identity: 0.767

--gtaatgagcaaaaggtcatgctgaacctgt	CRISPR spacer
cgctagt--gcaaaaggtcatgctgaagctaa	Protospacer
   **.*  ****************** **.

8. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to MG945777 (UNVERIFIED: Microviridae sp. isolate 3995-1801, complete genome) position: , mismatch: 7, identity: 0.767

--gtaatgagcaaaaggtcatgctgaacctgt	CRISPR spacer
tgctagt--gcaaaaggtcatgctgaagctaa	Protospacer
   **.*  ****************** **.

9. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to NZ_CP030091 (Lactobacillus reuteri strain YSJL-12 plasmid unnamed2, complete sequence) position: , mismatch: 8, identity: 0.733

gtaatgagcaaaaggtcatgctgaacctgt	CRISPR spacer
tcaacgagaaaaaggtcatgctgaacgaca	Protospacer
 .**.*** *****************

10. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to NC_012586 (Sinorhizobium fredii NGR234 plasmid pNGR234b, complete sequence) position: , mismatch: 8, identity: 0.733

gtaatgagcaaaaggtcatgctgaacctgt	CRISPR spacer
accgggagcaaacggtcattctgaacctga	Protospacer
.. . ******* ****** *********

11. spacer 3.1|1127872|30|LS483405|CRISPRCasFinder matches to MH319722 (Marine virus AG-345-D19 Ga0172267_103 genomic sequence) position: , mismatch: 8, identity: 0.733

gtaatgagcaaaaggtcatgctgaacctgt	CRISPR spacer
aaacttcacaaaaggtcttgctgaacctga	Protospacer
. * *  .********* ***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

1276959 : 1286214

Staphylococcus_phage(42.86%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
SQG80989.1\|1276959_1277811_-	DegV domain-containing protein spr1019	A0A0N9SI50	Staphylococcus_phage	5.8e-15	33.6
SQG80990.1\|1277979_1278621_+	hemolysin III-like protein	NA	NA	NA	NA
SQG80991.1\|1278800_1279292_-	Dihydrofolate reductase	A0A0N9S8H6	Staphylococcus_phage	9.7e-23	37.2
SQG80992.1\|1279307_1280258_-	thymidylate synthase	A0A0N9SH48	Staphylococcus_phage	2.0e-117	62.1
SQG80993.1\|1280269_1282162_-	ABC transporter ATPase	A0A2K9L0W2	Tupanvirus	1.2e-49	29.5
SQG80994.1\|1282190_1283384_-	CCA-adding enzyme	G3MAR3	Bacillus_virus	2.1e-34	39.3
SQG80995.1\|1283517_1284456_+	UPF0750 membrane protein ypjC	M1Q1P6	Streptococcus_phage	2.2e-52	38.8
SQG80996.1\|1284573_1285833_-	TPR repeat-containing protein ypiA	NA	NA	NA	NA
SQG80997.1\|1285938_1286214_-	nucleoid DNA-binding protein	A0A0H3UZA0	Geobacillus_virus	3.1e-26	68.5

DBSCAN-SWA_2

1386351 : 1394295

Bacillus_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
SQG81090.1\|1386351_1387350_-	lactate dehydrogenase related 2-hydroxyacid dehydrogenase	A0A1J0F959	Only_Syngen_Nebraska_virus	3.3e-46	35.8
SQG81091.1\|1387433_1387703_-	URI-like endonuclease	A0A0C5AS36	Spodoptera_frugiperda_granulovirus	8.5e-05	37.1
SQG81092.1\|1387689_1388436_-	uncharacterized protein yabB	NA	NA	NA	NA
SQG81093.1\|1388531_1389173_+	1-acyl-sn-glycerol-3-phosphate acyltransferase	NA	NA	NA	NA
SQG81094.1\|1389234_1391028_-	putative ABC transporter ATP-binding protein exp8	W8CYL7	Bacillus_phage	8.7e-45	26.4
SQG81095.1\|1391017_1391335_-	probable multidrug resistance ABC transporter ATP-binding/permease protein YheI	W8CYT2	Bacillus_phage	2.6e-05	47.2
SQG81096.1\|1391371_1392778_-	probable multidrug resistance ABC transporter ATP-binding/permease protein YheI	F2Y302	Organic_Lake_phycodnavirus	4.0e-05	31.9
SQG81097.1\|1392909_1393134_-	UPF0154 protein LVIS_1358	NA	NA	NA	NA
SQG81098.1\|1393233_1393482_-	UPF0291 protein LVIS_1359	NA	NA	NA	NA
SQG81099.1\|1393665_1394295_+	LexA repressor	A0A1B2APZ1	Phage_Wrath	1.6e-14	50.7

DBSCAN-SWA_3

1573922 : 1580523

Lactobacillus_phage(83.33%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
SQG81275.1\|1573922_1574975_-	Lyzozyme M1 (1,4-beta-N-acetylmuramidase)	D6PSS2	Lactobacillus_phage	1.5e-153	82.4
SQG81276.1\|1574974_1575490_-\|holin	phage holin, LL-H family	D6PSS1	Lactobacillus_phage	1.9e-45	62.1
SQG81277.1\|1575486_1575891_-	Xin Secretion/Phage Lysis Holin	A0A097BY69	Enterococcus_phage	1.7e-17	41.4
SQG81278.1\|1575947_1576118_-	Uncharacterised protein	D6PSR8	Lactobacillus_phage	2.5e-18	83.9
SQG81279.1\|1576132_1576264_-	Uncharacterised protein	D6PSR7	Lactobacillus_phage	8.5e-11	79.1
SQG81280.1\|1576276_1576747_-	Uncharacterised protein	NA	NA	NA	NA
SQG81281.1\|1576759_1577242_-	Uncharacterised protein	NA	NA	NA	NA
SQG81282.1\|1577351_1577831_-	Uncharacterised protein	NA	NA	NA	NA
SQG81283.1\|1577942_1578386_-	Uncharacterised protein	NA	NA	NA	NA
SQG81284.1\|1578485_1578980_-	Uncharacterised protein	NA	NA	NA	NA
SQG81285.1\|1578990_1580523_-	Uncharacterised protein	A0A1S5RCQ5	Lactobacillus_phage	7.0e-11	29.5

DBSCAN-SWA_4

1608744 : 1619325

Lactobacillus_phage(71.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
SQG81320.1\|1608744_1609212_-	prophage P1 protein 33, phage ArpU family transcriptional regulator	D6PSV8	Lactobacillus_phage	1.2e-83	98.1
SQG81321.1\|1609305_1609494_-	phage-like protein with HTH-domain	D7RWH5	Brochothrix_phage	4.8e-07	43.5
SQG81322.1\|1609624_1610242_+	Uncharacterised protein	NA	NA	NA	NA
SQG81323.1\|1610238_1610415_-	Uncharacterised protein	NA	NA	NA	NA
SQG81324.1\|1610446_1610638_-	Uncharacterised protein	D6PSV7	Lactobacillus_phage	3.9e-28	96.8
SQG81325.1\|1610618_1611044_-	YopX protein	D6PSV5	Lactobacillus_phage	2.5e-35	57.8
SQG81326.1\|1611027_1611147_-	Uncharacterised protein	NA	NA	NA	NA
SQG81327.1\|1611139_1611364_-	Uncharacterised protein	NA	NA	NA	NA
SQG81328.1\|1611370_1611583_-	Uncharacterised protein	NA	NA	NA	NA
SQG81329.1\|1611579_1611780_-	Uncharacterised protein	NA	NA	NA	NA
SQG81330.1\|1611792_1611972_-	Uncharacterised protein	NA	NA	NA	NA
SQG81331.1\|1612141_1612405_-	Uncharacterised protein	NA	NA	NA	NA
SQG81332.1\|1612392_1612812_-	putative phage resolvase	D6PSU4	Lactobacillus_phage	1.4e-43	60.4
SQG81333.1\|1612804_1613314_-	uncharacterized protein HI_1422	D2IZW4	Enterococcus_phage	2.3e-35	45.0
SQG81334.1\|1613314_1613506_-	phage-related antirepressor	D2IYT0	Enterococcus_phage	1.5e-08	60.8
SQG81335.1\|1613502_1614414_-	prophage P2a protein 20, replication protein DnaD domain	D6PSU3	Lactobacillus_phage	6.6e-17	62.7
SQG81336.1\|1614425_1615229_-	prophage P1 protein 19	A0A0P0IZH9	Lactobacillus_phage	2.1e-38	37.1
SQG81337.1\|1615263_1616133_-	phage recombinase RecT	A0A1B0YA63	Lactobacillus_phage	8.1e-65	51.7
SQG81338.1\|1616133_1616349_-	Uncharacterised protein	NA	NA	NA	NA
SQG81339.1\|1616339_1616633_-	Uncharacterised protein	NA	NA	NA	NA
SQG81340.1\|1616623_1616746_-	Uncharacterised protein	NA	NA	NA	NA
SQG81341.1\|1616742_1616901_-	Uncharacterised protein	D6PST6	Lactobacillus_phage	1.6e-16	76.9
SQG81342.1\|1616906_1617182_-	Uncharacterised protein	D6PST5	Lactobacillus_phage	7.5e-25	60.9
SQG81343.1\|1617186_1617696_-	Prophage Lp2 protein 13	D6PST4	Lactobacillus_phage	5.7e-42	53.8
SQG81344.1\|1617756_1617921_-	Uncharacterised protein	NA	NA	NA	NA
SQG81345.1\|1618053_1618431_+	Uncharacterised protein	NA	NA	NA	NA
SQG81346.1\|1618416_1618542_-	Uncharacterised protein	NA	NA	NA	NA
SQG81347.1\|1618541_1618790_-	Cro-like protein	NA	NA	NA	NA
SQG81348.1\|1618956_1619325_+	prophage P2a protein 9, phage Cro/CI family transcriptional regulator	A8ATX5	Listeria_phage	5.9e-09	39.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. LS483405

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection