CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
LR134274	Streptococcus salivarius strain NCTC8618 genome assembly, chromosome: 1	2 crisprs	DEDDh,csa3,DinG,WYL,cas3	0	1	5	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: LR134274_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134274_1

269618-269711

Orphan

Consensus_repeat	Method
TGTTCTAAAATTCGAGTTGGCAATTAA	CRISPRCasFinder

1 spacers

The CRISPR arrays of LR134274_1

>merge|LR134274|1|269618-269711|CRISPRCasFinder
TGTTCTAAAATTCGAGTTGGCAATTAAGAGCTGTTCCCACCCTAAATGTTATCTTAGTTATAAGATGTGTTCTAAAATTCGAGTTGGCGATTAA

>LR134274|1|1|269618-269711|CRISPRCasFinder
TGTTCTAAAATTCGAGTTGGCAATTAA	GAGCTGTTCCCACCCTAAATGTTATCTTAGTTATAAGATG
TGTTCTAAAATTCGAGTTGGCGATTAA

Protein	Signature genes	Signature genes Name	Protein_function
LR134274.1\|VED87239.1\|275803_276646_+\|putative-ABC-transporter,-integral-membrane-protein	unknown	unknown	gnl\|CDD\|224428
LR134274.1\|VED87235.1\|274177_274591_+\|Protein-of-uncharacterised-function-(DUF2992)	unknown	unknown	gnl\|CDD\|378596
LR134274.1\|VED87228.1\|269054_269540_+\|phosphatidylglycerophosphatase-B	unknown	unknown	gnl\|CDD\|238813
LR134274.1\|VED87241.1\|276664_277120_+\|transcriptional-regulator,-LytTr-family	unknown	unknown	gnl\|CDD\|335768
LR134274.1\|VED87213.1\|263712_264018_-\|Protein-of-uncharacterised-function-(DUF2752)	unknown	unknown	gnl\|CDD\|378499
LR134274.1\|VED87219.1\|265469_267797_+\|penicillin-binding-protein-2A	unknown	unknown	gnl\|CDD\|273955
LR134274.1\|VED87243.1\|277129_277561_+\|membrane-protein	unknown	unknown	gnl\|CDD\|378668
LR134274.1\|VED87233.1\|271501_274003_+\|leucyl-tRNA-synthetase	unknown	unknown	gnl\|CDD\|234743
LR134274.1\|VED87226.1\|268383_268923_+\|transcription-antitermination-protein	unknown	unknown	gnl\|CDD\|180161
LR134274.1\|VED87229.1\|269738_270548_-\|cof-family-hydrolase	unknown	unknown	gnl\|CDD\|319818
LR134274.1\|VED87245.1\|277642_278353_+\|MerR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|133381
LR134274.1\|VED87221.1\|267845_267998_+\|50S-ribosomal-protein-L33	unknown	unknown	gnl\|CDD\|234783
LR134274.1\|VED87215.1\|264017_264350_-\|TM2-domain-containing-protein	unknown	unknown	gnl\|CDD\|377473
LR134274.1\|VED87231.1\|270540_271308_-\|DeoR-family-transcriptional-regulator	unknown	unknown	gnl\|CDD\|224268
LR134274.1\|VED87217.1\|264534_265404_-\|RNA-pseudouridine-synthase-yhcT	unknown	unknown	gnl\|CDD\|223638
LR134274.1\|VED87223.1\|268006_268183_+\|preprotein-translocase-SecE-subunit	unknown	unknown	gnl\|CDD\|236066
LR134274.1\|VED87209.1\|261073_262693_+\|Chaperonin-GroEL-(HSP60-family)	unknown	unknown	gnl\|CDD\|234573
LR134274.1\|VED87247.1\|278564_279248_+\|macrolide-export-ATP-binding/permease-protein-MacB	unknown	unknown	gnl\|CDD\|213222
LR134274.1\|VED87211.1\|262776_263622_-\|Uncharacterised-protein	unknown	unknown	gnl\|CDD\|379585
LR134274.1\|VED87237.1\|274937_275804_+\|multidrug-ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054

Protein	Function_ID	Function_description	E-value
LR134274.1\|VED87239.1\|275803_276646_+\|putative-ABC-transporter,-integral-membrane-protein	gnl\|CDD\|224428	COG1511, COG1511, Predicted membrane protein [Function unknown].	0.000402127
LR134274.1\|VED87235.1\|274177_274591_+\|Protein-of-uncharacterised-function-(DUF2992)	gnl\|CDD\|378596	pfam11208, DUF2992, Protein of unknown function (DUF2992). This bacterial family of proteins has no known function. However, the cis-regulatory yjdF motif, just upstream from the gene encoding the proteins for this family, is a small non-coding RNA, Rfam:RF01764. The yjdF motif is found in many Firmicutes, including Bacillus subtilis. In most cases, it resides in potential 5' UTRs of homologs of the yjdF gene whose function is unknown. However, in Streptococcus thermophilus, a yjdF RNA motif is associated with an operon whose protein products synthesize nicotinamide adenine dinucleotide (NAD+). Also, the S. thermophilus yjdF RNA lacks typical yjdF motif consensus features downstream of and including the P4 stem. Thus, if yjdF RNAs are riboswitch aptamers, the S. thermophilus RNAs might sense a distinct compound that structurally resembles the ligand bound by other yjdF RNAs. On the ohter hand, perhaps these RNAs have an alternative solution forming a similar binding site, as is observed with some SAM riboswitches.	2.09155e-40
LR134274.1\|VED87228.1\|269054_269540_+\|phosphatidylglycerophosphatase-B	gnl\|CDD\|238813	cd01610, PAP2_like, PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.	9.25451e-13
LR134274.1\|VED87241.1\|276664_277120_+\|transcriptional-regulator,-LytTr-family	gnl\|CDD\|335768	pfam04397, LytTR, LytTr DNA-binding domain. This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.	8.01744e-21
LR134274.1\|VED87213.1\|263712_264018_-\|Protein-of-uncharacterised-function-(DUF2752)	gnl\|CDD\|378499	pfam10825, DUF2752, Protein of unknown function (DUF2752). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	8.31344e-07
LR134274.1\|VED87219.1\|265469_267797_+\|penicillin-binding-protein-2A	gnl\|CDD\|273955	TIGR02074, Includes:_Penicillin-insensitive_transglycosylase, penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
LR134274.1\|VED87243.1\|277129_277561_+\|membrane-protein	gnl\|CDD\|378668	pfam11457, DUF3021, Protein of unknown function (DUF3021). This is a bacterial family of uncharacterized proteins.	4.11258e-09
LR134274.1\|VED87233.1\|271501_274003_+\|leucyl-tRNA-synthetase	gnl\|CDD\|234743	PRK00390, leuS, leucyl-tRNA synthetase; Validated.	0
LR134274.1\|VED87226.1\|268383_268923_+\|transcription-antitermination-protein	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	3.28618e-82
LR134274.1\|VED87229.1\|269738_270548_-\|cof-family-hydrolase	gnl\|CDD\|319818	cd07516, HAD_Pase, phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily. Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	4.37576e-76
LR134274.1\|VED87245.1\|277642_278353_+\|MerR-family-transcriptional-regulator	gnl\|CDD\|133381	cd01106, HTH_TipAL-Mta, Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA. Helix-turn-helix (HTH) TipAL, Mta, and SkgA transcription regulators, and related proteins, N-terminal domain. TipAL regulates resistance to and activation by numerous cyclic thiopeptide antibiotics, such as thiostrepton. Mta is a global transcriptional regulator; the N-terminal DNA-binding domain of Mta interacts directly with the promoters of mta, bmr, blt, and ydfK, and induces transcription of these multidrug-efflux transport genes. SkgA has been shown to control stationary-phase expression of catalase-peroxidase in Caulobacter crescentus. These proteins are comprised of distinct domains that harbor an N-terminal active (DNA-binding) site and a regulatory (effector-binding) site. The conserved N-terminal domain of these transcription regulators contains winged HTH motifs that mediate DNA binding. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements. Unique to this family, is a TipAL-like, lineage specific Bacilli subgroup, which has five conserved cysteines in the C-terminus of the protein.	3.89753e-46
LR134274.1\|VED87221.1\|267845_267998_+\|50S-ribosomal-protein-L33	gnl\|CDD\|234783	PRK00504, rpmG, 50S ribosomal protein L33; Validated.	2.86471e-18
LR134274.1\|VED87215.1\|264017_264350_-\|TM2-domain-containing-protein	gnl\|CDD\|377473	pfam05154, TM2, TM2 domain. This family is composed of a pair of transmembrane alpha helices connected by a short linker. The function of this domain is unknown, however it occurs in a wide range or protein contexts.	3.06279e-13
LR134274.1\|VED87231.1\|270540_271308_-\|DeoR-family-transcriptional-regulator	gnl\|CDD\|224268	COG1349, GlpR, Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism].	1.4042e-69
LR134274.1\|VED87217.1\|264534_265404_-\|RNA-pseudouridine-synthase-yhcT	gnl\|CDD\|223638	COG0564, RluA, Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis].	7.89354e-84
LR134274.1\|VED87223.1\|268006_268183_+\|preprotein-translocase-SecE-subunit	gnl\|CDD\|236066	PRK07597, secE, preprotein translocase subunit SecE; Reviewed.	2.68913e-10
LR134274.1\|VED87209.1\|261073_262693_+\|Chaperonin-GroEL-(HSP60-family)	gnl\|CDD\|234573	PRK00013, groEL, chaperonin GroEL; Reviewed.	0
LR134274.1\|VED87247.1\|278564_279248_+\|macrolide-export-ATP-binding/permease-protein-MacB	gnl\|CDD\|213222	cd03255, ABC_MJ0796_LolCDE_FtsE, ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein. This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. An FtsE null mutants showed filamentous growth and appeared viable on high salt medium only, indicating a role for FtsE in cell division and/or salt transport. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.	8.78416e-103
LR134274.1\|VED87211.1\|262776_263622_-\|Uncharacterised-protein	gnl\|CDD\|379585	pfam14373, Imm_superinfect, Superinfection immunity protein. This family includes the E. coli bacteriophage T4 superinfection immunity (imm) protein. When E. coli is sequentially infected with two T-even type bacteriophage the DNA of the superinfecting phage is excluded from the host, into the periplasmic space. The immunity protein plays a role in this process.	9.2204e-08
LR134274.1\|VED87237.1\|274937_275804_+\|multidrug-ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	5.56217e-79

>LR134274.1|VED87228.1|269054_269540_+|phosphatidylglycerophosphatase-B
MNYKRFYDRISAPLRSYAKVLEGLNKLITRTFYLLFPIFLIWVWLRNGWFVLSTTVLIMGGGFFLLSLGRSLYNRPRPYQTWAIQPLIKKDSLGKSFPSRHVFSATVIAMLALALNPWLGGAMLFLAGALALLRVLGGVHYPSDVLAGYAIGILVGLLLYL
>LR134274.1|VED87226.1|268383_268923_+|transcription-antitermination-protein
MLDSFDKGWFVLQTYSGYENKVKENLLQRAQTYNMLENILRVEIPTQTVNVEKNGKVKEVEENRFPGYVLVEMVMTDEAWFVVRNTPNVTGFVGSHGNRSKPTPLLEEEIRQILISMGQTVDVFDTNIKVGDVVQIIDGAFMGQEGRVVEIENNKVKIMINMFGSETAAELELYQIAEL
>LR134274.1|VED87223.1|268006_268183_+|preprotein-translocase-SecE-subunit
MRQTGSIFKVLKDTTWPDRKQRWHDFISVLEYTAFFTVIIYAFDELLSRAMSALINFF
>LR134274.1|VED87221.1|267845_267998_+|50S-ribosomal-protein-L33
MAQKKASLACAECGSRNYSINVSSTPKPTRLEVNKFCKHCKKYTLHKETR
>LR134274.1|VED87219.1|265469_267797_+|penicillin-binding-protein-2A
MTFFDNLKNKLFKEENSGKGKDSQPAEKSKNLQNKIKGLFAKKPDEVEQAVEDLDMSQESQETSRYQRSKQKKPIDTTQPLGKVQAFLSKFTLSPRNPIRRFWRRYHIGKILFILVAMLVLTVGSYLFYIAKTTNVSDLQDALKATTVIYDKEGNQAGSLSGQKGTYVELDAISDSLENAVIATEDRTFYENSGVNVKRFLLAIVSMGRFGGGSTITQQLAKNAFLTQEQTVTRKAKEFFLSLELTKKYSKQEILTMYLNNAYFGNGVWGVEDASQKYFGTSAANLTVDEAATLAGMLKGPEIYNPIDNIKNATNRRNTVLANMVDDKKLSQADADSAAGVDMASRLDDTYQGTGDDYKYPSYFDAVIEEATKTYGLSEDEIVKNGYKIYTEMDANSQANMQQTYENTYLFPTSESDGSTAQSASVALDPTTGAVRGLVGRVGGTSDTTFRNFNYATQGKRSPGSTIKPLVVYAPALASGWSINKDLPNKPIDYNGYTPTNYGGVETEDVPMYQALANSYNIPAVYLFNQIGIQKGISYGQKFGLNFDNVPEELGISLGGGVTASPLQMAQAYATFANGGEMNTAYFITKIENASGDIIATHSKKSKRVISQSVANQMTSMMLGTFSNGSAVNANYTGYTMAGKTGTVQAEFNKDLTSDQWVIGYTPDVVMTTWIGFDKTDESHYLTGASSGTASTIFSYIAADVLPNTPGTEFTVENAYAADGQTLDYTADPNDSRNSSNKSWTDKASDVVNDVKDQASSLWDKITDSFSGLFR
>LR134274.1|VED87217.1|264534_265404_-|RNA-pseudouridine-synthase-yhcT
MTLHVEIINPYPVTTVKDLLETKLLIPRKIRHFLRTKKHVLINGETINWQSPVEKGDKISLTFDTEDYPEKIIPMGNASLVEPLYEDQHLIVVNKPEGMKTHGNEPTEIALLNHVSAYCGQTCYVVHRLDMETSGAVLFAKNPFILPILNRLLEDKKIQRQYWALAEGKFQTKETVYKDKIGRDRHDRRKRVVDPRKGQVAYTTITRLKAFKGASLVNCQLKTGRTHQIRVHLAHHGHAILGDPLYSHRPASRLMLHAHTLSFTHPLTLDKITVKASSDSFEQGLKNHK
>LR134274.1|VED87215.1|264017_264350_-|TM2-domain-containing-protein
MNPVDQWLAINAKYFPTEQVQYIRQRLEALPEQQLSMLYSISFQDPTMMLVISLFGGSLGIDRFILGQVGLGVGKLLTCGGCGIWSIVDWFLIMDATRQSNAQKLFAVIG
>LR134274.1|VED87213.1|263712_264018_-|Protein-of-uncharacterised-function-(DUF2752)
MKNYFTRLWAYHQRFFRLYLLVSVAVYGVYLLHLPTPLSLILRPFGLKGWSAGLTRASVRLLHLDWQGAWDYNPLIYPLVVYILTYFFLFPIFSVKKIIRK
>LR134274.1|VED87211.1|262776_263622_-|Uncharacterised-protein
MKQQDWIDFFQAVNGRNPSIQEMAEAAQKGEFVRETPKQTVEVTETVSQKETVETKQDSKVVEPVESAPSTEVVETAEKDVDSYDVAEEPLTNSMVDEEETFQATNLAQENQSKTFQEQVKPVVETASQTVNQFANQTGETFQQASKNLNETWKKQDKKTQTNLIMLAVASIPAILWALGMILLGIASDDLSAGLITALLSVIINFPLVVLLILPALLNKTDKKWPIFILSFLLGWTFIGWIILLAVSINTNKEAERIRQQQMMMQMAGQQGSSDTFNPFQ
>LR134274.1|VED87209.1|261073_262693_+|Chaperonin-GroEL-(HSP60-family)
MAKDIKFSSDARAAMVRGVDTLADTVKVTLGPKGRNVVLEKAFGSPLITNDGVTIAKEIELEDHFENMGAKLVSEVASKTNDIAGDGTTTATVLTQAIVREGLKNVTAGANPIGIRRGIEAAVATAVEELKAIAQPVANKEAIAQVAAVSSRSEKVGEYISEAMERVGNDGVITIEESRGMETELEVVEGMQFDRGYLSQYMVTDNEKMVADLENPFILVTDKKISNIQDVLPLLEEVLKTSRPLLIIADDVDGEALPTLVLNKIRGTFNVVAVKAPGFGDRRKAMLEDIAVLTGATVITEDLGLELKDATMAALGQASKVTVDKDSTVIVEGAGSTEAIANRVNLIKSQLETTTSEFDREKLQERLAKLSGGVAVVKVGAATETALKEMKLRIEDALNATRAAVEEGIVAGGGTALVNVIAKVAELDLEGDDATGRNIVLRALEEPVRQIAYNAGYEGSVIIDKLKNSPVGTGFNAANGEWVDMVEAGIIDPVKVTRSALQNAASVASLILTTEAVVANKPEPEAPAAPAMDPGMMGY
>LR134274.1|VED87229.1|269738_270548_-|cof-family-hydrolase
MSNIRLIISDIDGTILTSNHQVDEQLIEVMPELEKANIPFVLASARSPLGMQPIAHKLGLHDNPIACYNGALVLEGDRTIIQHPVDKAEIQDLLNYLSTDYPSVSVNIYSGKDWITNELDKWSQLEGSITGESPIIKELQDTVSDSEPPIHKLLLIDEPEVIQDLHQKLLSMDFPQTAFYLSKDNYLEVTAKHVSKEHALLELSKYYDLPLEQVMTIGDNFNDSPMLALAGLGIAMGNAPEGVKETANLVTASNDEHGVAQAIRKHVLN
>LR134274.1|VED87231.1|270540_271308_-|DeoR-family-transcriptional-regulator
MYQEQRLEKILTLLEERGSLSVKEMVDALGVSKDTVRRDFDCLSQRNLAQRTHGGILPVKNTTVLGFQERQEELTEDKKKLADLALSFVKDQSLLFFDVSTLMLEVSQKLTKSVTVYSHSLDNALVLSGKEGIDFHLLGGRFYSKNRFYYSLHETQLLQHLQFDLAFFGAASLSQGVVSYEDEEDVAVKQLAMQAARTKILIAESDKYEKHSKYILSKIEDFDYWITDKEPDPDLVESLKDKVTILYDGKDSDYE
>LR134274.1|VED87233.1|271501_274003_+|leucyl-tRNA-synthetase
MSFYNHKEIEPKWQKYWADHHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGYNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDDLDWPESIKDMQRNWIGKSTGANVTFKVKGTDKEFTVFTTRPDTLFGATFTVLAPEHDLVDAITTPEQAEAVADYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEIPIWIADYVLASYGTGAVMAVPAHDERDWEFAKQFDLPIVEVLEGGNVEEAAYTEDGLHVNSDFLNGLNKEEAIAKIVAWLEEKGFGQEKITYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLFNQGMILGTSYRDHRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITSKEIVEENNGALDKVYNETVKSVTEQIESMKFNTAIAQLMVFVNAANKEDKLYVDYAKGFIQLIAPFAPHLAEELWQTVAETGESISYVAWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDLSREELQEVALANEKVKAEIDGKEIVKVIAVPNKLVNIVVK
>LR134274.1|VED87235.1|274177_274591_+|Protein-of-uncharacterised-function-(DUF2992)
METISIGLTVYFEDGFWHGLFEQVYRESYQVCRVTFGQEPKDDEILEILQTQFTQLSFSPETTAKQHVKIKNPKRLQRAVKKQVNQKVSSKSKELLQLQYEERKKISKHQSSVQKQLLKQEKFERKQQKRRDKHKGH
>LR134274.1|VED87237.1|274937_275804_+|multidrug-ABC-transporter-ATP-binding-protein
MILQAKNISKRYGNYLAVNDIHLQFEKGTFNAILGPNGAGKSTTISMLIGLKQPTKGEIIYEPGTKIGVVFQTSVLDEMLTVRENLAIRARQYKGLKPNRVSDLIGRLGLSTFQKQRYGTLSGGQKRRVDIARALLSQPDILFLDEPTTGLDIQTRKSIWDLLYQLQREEGMTVVLTTHYLDEADEADLIYIVDHGKVIVQGSALDIKSQYAKNILKIRFKEIQQIESLKTSGMSVEQQSQLEYVFQPESEREAIDYLAQVRDNLAHFEFRSGTMDDAFIALTGREVR
>LR134274.1|VED87239.1|275803_276646_+|putative-ABC-transporter,-integral-membrane-protein
MLALLKRNFLLYFRNRSGVFFSLLGALISFILYIIFLQKNLTDAWAQLPNNGPLLNNWLMSGTLAVTGITTSLAALTQLVKDREHQVDQDLYLSDQGKWRLPFSYLASAIIISFAMQVLMYVLMCGYFREVPKLSILPEVLLIMLLSSLLSSLVNAIFVHFFQSVDSLGKFATIVGTASGFLVGTYVPLGVLPNFAQLLMKCTPATYIAALYRQVLMNETLSETFKDQDDLRQEFQEKMGVQLKWQELLTKENTYLIVLGGILLVGILWAVLVKKSSKKK
>LR134274.1|VED87241.1|276664_277120_+|transcriptional-regulator,-LytTr-family
MKLRFEEKSGISTKDPCVVIQAERLSDQAREVMDYLEQFSVVNQVVIPIKTDDHLVMVKIDDIILAEIDKNVLTIYTIDKTYTMKETLTNFQHRINRRSFLQISRHAVMNIDHLESLSDSFSGNMMAKMTGGVKSSVSRKYVKSLMDYLGV
>LR134274.1|VED87243.1|277129_277561_+|membrane-protein
MKRLIAYFVSGVRTGSFFYLALLLLGQLIPQLIYPKVSVGNILALFMMSGLMGMLSWILEELDRMSYRFRVILHFLLTAIVLTVTCLISGWYEALTNPAIWIVFIFVYIIIWLYLIWQMHMRTQRINQALLHRRSQKKKSNKL
>LR134274.1|VED87245.1|277642_278353_+|MerR-family-transcriptional-regulator
MKSVKEVSQLSGVSVRTLHYYDEIDLLKPSVVAENGYRYYNRDAVVRLQEILLYRELDFPLKKIKEIVGQPGYDKVQALRDQIKLLELKKSRLEAVIAHAKALQMEEEEMSFEAFDQKAVEAFQEEAQARWGQTEAYQAFVAKGEESFPEVTKEMTAIMSTFGQLKEYNPGDDSVQEQVKALQDYISQHFYPCDQTVLVGLGQMYQTDNRFSSFIDKVGGRGTAAFLAEAIRIYCQ
>LR134274.1|VED87247.1|278564_279248_+|macrolide-export-ATP-binding/permease-protein-MacB
MSILTIDHISKYYNLDGTNQERALNDVTLEIAPGKITAIYGPSGCGKTSLLSIISGLDSQYQGNLYFKNQNMRDFSERDLTYFRKAHIGFVFQNFNLIPHQSVLENVKMPLYVKNMTDKEMVKIAERELSRLGIGDFIKKNVKQLSGGQKQRVAIARALVNNPEMIVADEPTGSLDSQSQENVLEIFKELAEAGKTVIIVTHNPEVADYADVVIKMKDGEVVETIEK

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Crispr_ID: LR134274_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134274_2

685076-685178

Orphan

Consensus_repeat	Method
GGACAAACCCGAGAATGTCCCTG	CRISPRCasFinder

1 spacers

The CRISPR arrays of LR134274_2

>merge|LR134274|2|685076-685178|CRISPRCasFinder
GGACAACTTCGGGAATGTCCCTGTCCCTGAGGGACAAACCCGAGAATGTCCCTGTGTCCCTGAGGTGTCTCTAGGGACAAGGACAAACCCGAGAATGTCCCTG

>LR134274|2|2|685076-685178|CRISPRCasFinder
GGACAACTTCGGGAATGTCCCTG	TCCCTGAGGGACAAACCCGAGAATGTCCCTGTGTCCCTGAGGTGTCTCTAGGGACAA
GGACAAACCCGAGAATGTCCCTG

Protein	Signature genes	Signature genes Name	Protein_function
LR134274.1\|VED87987.1\|685670_686069_+\|phage-protein	unknown	unknown	gnl\|CDD\|226936
LR134274.1\|VED87991.1\|686292_686568_+\|Gp89	unknown	unknown	unknown
LR134274.1\|VED87978.1\|680621_681185_+\|phage-protein	unknown	unknown	unknown
LR134274.1\|VED87980.1\|681184_682768_+\|DNA/RNA-helicase	unknown	unknown	gnl\|CDD\|223989
LR134274.1\|VED87994.1\|686689_686848_+\|Uncharacterised-protein	unknown	unknown	unknown
LR134274.1\|VED87970.1\|676107_676263_+\|Uncharacterised-protein	unknown	unknown	unknown
LR134274.1\|VED87998.1\|686983_687232_+\|Protein-of-uncharacterised-function-(DUF1642)	unknown	unknown	gnl\|CDD\|369557
LR134274.1\|VED87976.1\|679509_680607_+\|phage-protein	unknown	unknown	gnl\|CDD\|379213
LR134274.1\|VED87968.1\|675698_675938_+\|Phage-excisionase	unknown	unknown	unknown
LR134274.1\|VED87992.1\|686522_686693_+\|Uncharacterised-protein	unknown	unknown	unknown
LR134274.1\|VED87984.1\|685429_685681_+\|Uncharacterised-protein	unknown	unknown	unknown
LR134274.1\|VED87989.1\|686065_686293_+\|phage-associated-protein	unknown	unknown	unknown
LR134274.1\|VED87982.1\|682778_685028_+\|ATPase	unknown	unknown	gnl\|CDD\|226126
LR134274.1\|VED88002.1\|687610_688015_+\|phage-protein	unknown	unknown	gnl\|CDD\|273746
LR134274.1\|VED87965.1\|675332_675656_-\|Uncharacterised-protein	unknown	unknown	unknown
LR134274.1\|VED87972.1\|676470_678192_+\|lpxtg-cell-wall-surface-protein,-collagen-binding-domain-protein	unknown	unknown	gnl\|CDD\|227268
LR134274.1\|VED87996.1\|686835_686991_+\|Uncharacterised-protein	unknown	unknown	unknown
LR134274.1\|VED87974.1\|678196_679510_+\|chromosome-segregation-ATPases	unknown	unknown	gnl\|CDD\|274009
LR134274.1\|VED88000.1\|687296_687614_+\|phage-protein	unknown	unknown	gnl\|CDD\|254062
LR134274.1\|VED87963.1\|675212_675344_+\|Uncharacterised-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
LR134274.1\|VED87982.1\|682778_685028_+\|ATPase	gnl\|CDD\|226126	COG3598, RepA, RecA-family ATPase [DNA replication, recombination, and repair].	5.06713e-117
LR134274.1\|VED87980.1\|681184_682768_+\|DNA/RNA-helicase	gnl\|CDD\|223989	COG1061, SSL2, DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair].	1.50454e-86
LR134274.1\|VED88000.1\|687296_687614_+\|phage-protein	gnl\|CDD\|254062	pfam07116, DUF1372, Protein of unknown function (DUF1372). This family consists of several Streptococcus bacteriophage sequences and related proteins from Streptococcus species. Members of this family are typically around 100 residues in length and their function is unknown.	3.01788e-40
LR134274.1\|VED88002.1\|687610_688015_+\|phage-protein	gnl\|CDD\|273746	TIGR01671, hypothetical_phage_protein, phage uncharacterized protein TIGR01671. This model represents an uncharacterized, well-conserved family of proteins found in bacteriophage and prophage regions of Gram-positive bacteria. [Mobile and extrachromosomal element functions, Prophage functions, Hypothetical proteins, Conserved].	1.62623e-16
LR134274.1\|VED87976.1\|679509_680607_+\|phage-protein	gnl\|CDD\|379213	pfam13479, AAA_24, AAA domain. This AAA domain is found in a wide variety of presumed phage proteins.	6.16741e-82
LR134274.1\|VED87972.1\|676470_678192_+\|lpxtg-cell-wall-surface-protein,-collagen-binding-domain-protein	gnl\|CDD\|227268	COG4932, COG4932, Predicted outer membrane protein [Cell envelope biogenesis, outer membrane].	1.42965e-18
LR134274.1\|VED87998.1\|686983_687232_+\|Protein-of-uncharacterised-function-(DUF1642)	gnl\|CDD\|369557	pfam07852, DUF1642, Protein of unknown function (DUF1642). The sequences making up this family are derived from various hypothetical phage and prophage proteins. The region in question is approximately 140 amino acids long.	0.000327687
LR134274.1\|VED87974.1\|678196_679510_+\|chromosome-segregation-ATPases	gnl\|CDD\|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.81435e-09
LR134274.1\|VED87987.1\|685670_686069_+\|phage-protein	gnl\|CDD\|226936	COG4570, Rus, Holliday junction resolvase [DNA replication, recombination, and repair].	4.86431e-39

>LR134274.1|VED87982.1|682778_685028_+|ATPase
MSEGTFDLIPLLDYIDPSTLSYQEWVNVGMALKQEGYTAMDWDTWSQSDSRYKKGECFSKWDTFQYDGGGAVTGATITQMAKDNGWEPMNKSGKSYELDWDSTIDRDYQIVDKNWVESKEIREPINWHPVQDLVKYIETLFEMTDLVGYVTSTYPIETENGPIYKPTQGNYDRTAGELIKELQSNGDDIGAVFGDYKEEAGAWIRFNPLDGKGVKNDNVTDFRYALVESDSMELGKQYALFKELELPIATLVHSGHKSLHAVVRVDARDYQEYRKRVDYIYQICKKNGLDIDTQNRNPSRLSRMPGVIRNGHKQFLIDTNLGKANYEEWYQWVEDLNDDLPDPETLADEWDHLPDLAPELIHGVLRQGHKMLIAGPSKAGKSFALIELSIALAEGKEWLGWQCEQGRVLYVNLELDRPSALHRFKDVYTAMGIEPKCVANIDIWNLRGKTVPMDKLAPKLIRRSLKKNYQAVIIDPIYKVLTGDENSADQMAHFTNQFDKVATELGCAVIYCHHHSKGSQGGKKSMDRASGSGVFARDPDALVDLVELDLNEDIINARIEKATAKIYQRALQEQANDYYQHYVSLDDLESRYQMQQHFDKGIPDIMKREPYLKEVKDTVRSIEIASAWRVEGTLREFAKFPPRNMWFSYPVHEVDTTGVLADIQLEDAAPGWKKNLDSKKGNESKKKTADERFTTAMQVLFDGITPVELNDVVEYFSTEDKPVSEKTIRRWVKNNGDFEVKNNQILPKK
>LR134274.1|VED87980.1|681184_682768_+|DNA/RNA-helicase
MQLRPYQEEARVKVQQEWKEGRKRTLLVLPTGCGKTIVFSKIIEDRVKMGERVLVLAHRSELLEQASDKLMTATGLGTALEKAENTSIGSWFRVVVGSVQTMQREKRLSQFPPNHFDTIVIDEAHHAISDGYQRVLEHFGEANVLGVTATPDRGDMRNLGSYFDSLAYEYPLVDAIKSGYLSKITAITIPLELDLSTVSQQGGDFKASEIGTALDPYLEQIADEMVKQCKNRKTVVFLPLVKTSQKFRDILNEKGFRAAEVNGESKDRAEILEDFDKDKYNVLCNSMLLTEGWDCPTVDCVVVLRPTKVRALYSQMVGRGTRLAPGKENLLLLDFLWHTERHELCRPAHLIASSPEVAKKMTENMAEDTEVEFSLLEAEEQAGKDVVAEREEALAKQLAEQRKKKRKLVDPLQFEMSIQAEDLADYVPSFGWEMAPPSEKQLKALEKFGIYTEEIGNAGKAGKLLDRLNKRKDSGLTTPKQIRLLEGRGFRNVGMWKFEDASNLINRIAASGWRMPKGIIPATYQPE
>LR134274.1|VED87978.1|680621_681185_+|phage-protein
MTTLNNNFQREFGWDDTIQEDAKEFITLTPGDYVFTVTNFERGRHAPNPQNPGKLPACNKAIITIQVETEEGLATMTHNLFLHSSTEGMLSAFFGAIGQKKRGEPLQMNWNTVVGSTGVCRVGNRTYNDTVYNDVKQMIYADSVDWTKVLNANVAPQGGQQAPQQNQGYQQPQQPQQAPNGGGFGGF
>LR134274.1|VED87976.1|679509_680607_+|phage-protein
MQITRGIKARAQKVVIYGPEGIGKSSFAAQFPDPVFIDTEGSTDNMDVARLDKPSSWTMLMNEIAFIKANPDSCKTLVVDTIDWAESLAVESVCAQHGKKGIEDFGWGNGYTYVREEIGRFLNSLSELIDLGINVVLTAHAQIKTFTQPDEMGSYDRYELKLGKKTSSQTAPLVKEWADMVLFCNYETIVMTDEKSKKSKAQGGQRVMYTQHHPAWDAKNRHNLPNKLPLDYAGIAHIFNNVQAAQQPAKVQTPPPAPKEPTVPAEETPIQTQTPTPTPQEPVNPAPVERGAYQEPAPFIEPALRDLMIANQVTEQELQQAVASKGYYPIETPISMYDKSFIDGALVATWDRVFEMVKEIRGSEF
>LR134274.1|VED87974.1|678196_679510_+|chromosome-segregation-ATPases
MSIAINKLEIENVKRIKAVKVEPSPTGLTVIGGNNNQGKTSVLDSIAWALGGNRFKPSKAAREGSVVPPSLKITMSNGLIVERKGKNSSLKVIDPNGNKGGQQLLDSFVEELAINLPKFMDSTAKEKADILLQIIGVGPQLAELEIKEKQLYDQRHAIGVIADQKEKFAKEQTYYPDAPKELVSIADLIAEQQEVLAKNGENARKRQNAQQIKTAYEGKLAEVNRLAEQLKAAQAELETLENDLQIATDLTIDLIDESTEEIESNIANIEQTNLKVRANLDKEKAEEEARVQREEYNRLSSEIEAVRKDKRDLLTNADLPLEGLSVNDGKLLYLGQEWDNMSGSQQLMVATAIVRKLKPDCGFVLIDKLEQMDQITLDQFGKWLEDEGLQAIATRVSTGDECSIIIEDGYSLDNKTHQPTTEAKSETPQTPSWQGGF
>LR134274.1|VED87972.1|676470_678192_+|lpxtg-cell-wall-surface-protein,-collagen-binding-domain-protein
MKTLNTQTVAKPGFTKSKAFGLCGTLAIATALLIGAGQVSADETTAPVADTQPAVSNVYTADNAGNVTVTPSETAAPVESQPIAEAPATTTEVAQPVAETPAAPTTVTKEGDTINVENPNVEVTFPNGNGKYSPFEVEYKDIQIPDDVPVNAGDKVTFDLPEEVKFQTSYEFDVHNPEKAVVGKATADATTNKVTTVFNDYFKTHPLNKSMSLKLDASWTDKVVAGKPVNINFNGTVVTANIGSEQVIGKDELIAKWGFQDKEDPTVINWTARVNYAKRVLNYVSIIDTMSDNQKLVDNYFEIKSIESVDPWIDKGSAMDLVKSISKSDHGFTIKMDRLDHMIYINYKTKLINAVKDSVNPTNKIELKAESDGAISHSYVQLVGGKGDASGENKPEPTFEIPHDAPKYEKPEFEGGIPGIPEVRELPEYTEPIGTVPNEAPVYDKPEWNGGIPGIPEVRELPPFEGGVVPNDAPILDLPELEIPVEPDKPVTPKELPSKPVDAPKTKEAEYATVSYNFVPVSKETPKTAVYGGVLPNTGEKEGIASALGLVVIAAGITTLGLSFKKYNEEKED
>LR134274.1|VED87970.1|676107_676263_+|Uncharacterised-protein
MKKLFAWLWSKKQQEPEYFFEPVWTPREINDQKYEARQKRERELLAKYGNR
>LR134274.1|VED87968.1|675698_675938_+|Phage-excisionase
MKITYKPAGINETAEWGDYEHLMQRWEGLGKSMAKNLIREMRDNKDFRGYVVNPTHKLVFINYEGFKSFIEWKTRNRFK
>LR134274.1|VED87965.1|675332_675656_-|Uncharacterised-protein
MIETVSKQARKLLKEMIEVIDDSNCVIYEDYSDLIEQDLLAIEELISLSFIEQYLTNDFRITSRGLIFLRQYKTFSRQLWLTSFWIPLFVSVFGTAITLLIQNWLFN
>LR134274.1|VED87963.1|675212_675344_+|Uncharacterised-protein
MKTLKKLKEFFESNLDGYDVALAIIGSLIGVVIGTAIFWLLVK
>LR134274.1|VED87984.1|685429_685681_+|Uncharacterised-protein
MARKKKTYSVKLDIGKKMPPLYHTLPGQDFWYSDSEVLKWIANQPILLNWVKDQLKTAGYITYDRQTGKWTGIDYRDEVGYDD
>LR134274.1|VED87987.1|685670_686069_+|phage-protein
MMIEFFVPMKKIPTTTHQQKKVAVVNGKPKFYEPQKLKEARDLFLTLLAPYTPNEKIEGPIRLTVKWLFPKIKKATHGQYKTTKPDTDNLQKLLKDCMTDLEYWEDDAQVASEIAEKFWSDTVGIYVKVEEL
>LR134274.1|VED87989.1|686065_686293_+|phage-associated-protein
MNYINFFESEVPNWMRENNQMMQQVGFNTPAYWEWVVVSIDKVCEKYNNDTLVKNQFHIIWDFLDEKAREVSGNN
>LR134274.1|VED87991.1|686292_686568_+|Gp89
MVKRWNDRMAGVKYAPRPYEPATVLECVEVFSRWFYTTHQKKGVVATKLGIGNKKLNRILTLEQLPDEELLKEMMKLCERKSLHSTRVKNC
>LR134274.1|VED87992.1|686522_686693_+|Uncharacterised-protein
MRAKEFALYKGEELLAMGTKREIAKQLGVSASTVGYYGTPVYARRTSENGRRLVEL
>LR134274.1|VED87994.1|686689_686848_+|Uncharacterised-protein
MKYKVIVYYDNMEDSEHIFSNKNDAINELHRLRGVKYRNSRMYTVELVECGG
>LR134274.1|VED87996.1|686835_686991_+|Uncharacterised-protein
MRWIVRVARTMDDVKECYFTDKDKALKHIEALKKLSMAVDDATVWMEEIDD
>LR134274.1|VED87998.1|686983_687232_+|Protein-of-uncharacterised-function-(DUF1642)
MIRTKWLEVDKETRYTVRVKGIDGYCKYLNRDTKTQKWLFASKTELERFRAHHTRKELEKADFGWVFDCPGVEVKEVDDGND
>LR134274.1|VED88000.1|687296_687614_+|phage-protein
MTNLKRSQKKRIYNELAVATILLLVSLAINVTTVLRVVNRPIETVVIHKADNAVELHGKVTGKSKIKNLYTLDCGAYGKFLVSKEQYDSVNVGDDIPSYLRGRGQ
>LR134274.1|VED88002.1|687610_688015_+|phage-protein
MIPRLRAWDKEFKEMVQVDALVFDEQIIKATYKNGNVVKEDLKNYVLMQSTGLKDKNGKEIFEGDILTTGKRTGVVKNHRTLGFYMNDARGNNWWFGSDVDLAEFEDFTRDVARKIGILGNIYTNPELAEVKHD

You can click texts colored in the table to view more detailed information

Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Identity
LR134274_2	2.1\|685099\|57\|LR134274\|CRISPRCasFinder	685099-685155	57	MK448979	Streptococcus phage Javan534, complete genome	13372-13428	1.0
LR134274_2	2.1\|685099\|57\|LR134274\|CRISPRCasFinder	685099-685155	57	MK448799	Streptococcus phage Javan535, complete genome	13372-13428	1.0
LR134274_2	2.1\|685099\|57\|LR134274\|CRISPRCasFinder	685099-685155	57	MK448800	Streptococcus phage Javan539, complete genome	13373-13429	1.0

1. spacer 2.1|685099|57|LR134274|CRISPRCasFinder matches to MK448979 (Streptococcus phage Javan534, complete genome) position: , mismatch: 0, identity: 1.0

tccctgagggacaaacccgagaatgtccctgtgtccctgaggtgtctctagggacaa	CRISPR spacer
tccctgagggacaaacccgagaatgtccctgtgtccctgaggtgtctctagggacaa	Protospacer
*********************************************************

2. spacer 2.1|685099|57|LR134274|CRISPRCasFinder matches to MK448799 (Streptococcus phage Javan535, complete genome) position: , mismatch: 0, identity: 1.0

tccctgagggacaaacccgagaatgtccctgtgtccctgaggtgtctctagggacaa	CRISPR spacer
tccctgagggacaaacccgagaatgtccctgtgtccctgaggtgtctctagggacaa	Protospacer
*********************************************************

3. spacer 2.1|685099|57|LR134274|CRISPRCasFinder matches to MK448800 (Streptococcus phage Javan539, complete genome) position: , mismatch: 0, identity: 1.0

tccctgagggacaaacccgagaatgtccctgtgtccctgaggtgtctctagggacaa	CRISPR spacer
tccctgagggacaaacccgagaatgtccctgtgtccctgaggtgtctctagggacaa	Protospacer
*********************************************************

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

386397 : 391879

Streptococcus_phage(66.67%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VED87447.1\|386397_387162_+	branched-chain amino acid ABC transporter ATPase	A0A2H4PQG7	Staphylococcus_phage	5.2e-15	24.8
VED87449.1\|387161_387872_+	high-affinity branched-chain amino acid transport ATP-binding protein livF	A0A2H4PQG7	Staphylococcus_phage	6.3e-15	26.9
VED87451.1\|388006_388666_+	AcuB family protein	M1NSC5	Streptococcus_phage	1.9e-66	58.7
VED87452.1\|388850_389777_-	cysteine synthase	A0A1X9I5K7	Streptococcus_phage	9.4e-144	81.8
VED87454.1\|389878_390505_-	Xaa-Pro dipeptidase	A0A1X9I5T8	Streptococcus_phage	3.5e-70	62.3
VED87456.1\|390559_391879_+	late competence protein required for DNA uptake	A0A1X9I5S6	Streptococcus_phage	1.5e-123	52.8

DBSCAN-SWA_2

655035 : 744105

102

Streptococcus_phage(72.31%)

protease,tRNA,terminase,tail,holin,integrase,capsid

attL 671627:671670|attR 712557:712600

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VED87919.1\|655035_655533_+\|protease	putative metalloprotease ykjF	NA	NA	NA	NA
VED87921.1\|655513_655918_+	diacylglycerol kinase	NA	NA	NA	NA
VED87923.1\|655940_656840_+	GTP-binding protein Era	NA	NA	NA	NA
VED87925.1\|656884_657706_+	formamidopyrimidine-DNA glycosylase	G3MA33	Bacillus_virus	7.5e-28	33.3
VED87927.1\|657681_658296_+	dephospho-CoA kinase	NA	NA	NA	NA
VED87929.1\|658346_659570_+	multi-drug resistance efflux pump	NA	NA	NA	NA
VED87931.1\|659751_659988_+	preprotein translocase subunit SecG	NA	NA	NA	NA
VED87933.1\|660050_662504_+	ribonuclease R	Q0GXV6	Lactococcus_phage	6.4e-91	39.9
VED87935.1\|662525_662990_+	SsrA-binding protein	W5RAM5	Staphylococcus_phage	1.1e-41	56.4
VED87937.1\|663136_664543_+	putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase	A0A1V0S9I2	Catovirus	1.6e-25	43.5
VED87939.1\|664544_664913_+	general stress protein GSP13	NA	NA	NA	NA
VED87941.1\|665012_666095_-	Xaa-Pro dipeptidase	NA	NA	NA	NA
VED87943.1\|666407_667409_+	catabolite control protein	NA	NA	NA	NA
VED87944.1\|667468_668536_+	MmcQ protein	NA	NA	NA	NA
VED87946.1\|668548_669664_+	glycerate kinase	W6LM47	Streptococcus_phage	6.0e-137	86.3
VED87948.1\|669703_670159_-	glycogen synthase	W6LLD2	Streptococcus_phage	2.9e-66	82.8
VED87950.1\|670365_671670_+	Enolase	W6LP63	Streptococcus_phage	1.4e-246	99.5
671627:671670	attL	NA	NA	NA	NA
VED87952.1\|671727_672894_-\|integrase	phage integrase family protein	W6LMU7	Streptococcus_phage	3.6e-209	95.3
VED87953.1\|672995_673388_-	cI-like repressor, metallo-prtoeinase motif protein	F8HGP6	Streptococcus_phage	8.2e-57	88.4
VED87955.1\|673403_673976_-	orf73	O48382	Streptococcus_phage	3.5e-32	95.9
VED87957.1\|673968_674397_-	Uncharacterised protein	A0A1S5SEV0	Streptococcus_phage	2.7e-21	35.5
VED87959.1\|674398_674782_-	prophage LambdaSa03, transcriptional regulator,Cro/CI family	O34035	Streptococcus_phage	7.5e-31	58.5
VED87961.1\|674951_675188_+	prophage pi2 protein 05	A0A286QMT7	Streptococcus_phage	6.7e-22	73.9
VED87963.1\|675212_675344_+	Uncharacterised protein	NA	NA	NA	NA
VED87965.1\|675332_675656_-	Uncharacterised protein	NA	NA	NA	NA
VED87968.1\|675698_675938_+	Phage excisionase	W6LM55	Streptococcus_phage	1.2e-39	92.4
VED87970.1\|676107_676263_+	Uncharacterised protein	F8HGQ3	Streptococcus_phage	9.1e-20	90.2
VED87972.1\|676470_678192_+	lpxtg cell wall surface protein, collagen binding domain protein	A0A2H4IZY2	uncultured_Caudovirales_phage	1.4e-169	65.6
VED87974.1\|678196_679510_+	chromosome segregation ATPases	Q5YA97	Bacillus_phage	1.2e-141	66.6
VED87976.1\|679509_680607_+	phage protein	A0A0K2CZH1	Paenibacillus_phage	2.5e-111	55.9
VED87978.1\|680621_681185_+	phage protein	A0A097BY29	Enterococcus_phage	3.0e-36	50.7
VED87980.1\|681184_682768_+	DNA/RNA helicase	A0A097BY72	Enterococcus_phage	1.2e-236	78.4
VED87982.1\|682778_685028_+	ATPase	Q5YA88	Bacillus_phage	2.2e-279	62.5
VED87984.1\|685429_685681_+	Uncharacterised protein	NA	NA	NA	NA
VED87987.1\|685670_686069_+	phage protein	Q5YA86	Bacillus_phage	1.1e-40	60.3
VED87989.1\|686065_686293_+	phage associated protein	NA	NA	NA	NA
VED87991.1\|686292_686568_+	Gp89	A0A286QRW8	Streptococcus_phage	3.0e-29	78.0
VED87992.1\|686522_686693_+	Uncharacterised protein	A0A286QMT9	Streptococcus_phage	2.3e-16	76.8
VED87994.1\|686689_686848_+	Uncharacterised protein	A0A2H4IZX2	uncultured_Caudovirales_phage	1.5e-22	98.1
VED87996.1\|686835_686991_+	Uncharacterised protein	A0A2H4J2W3	uncultured_Caudovirales_phage	2.9e-10	82.9
VED87998.1\|686983_687232_+	Protein of uncharacterised function (DUF1642)	L0P2R5	Streptococcus_phage	1.6e-18	61.4
VED88000.1\|687296_687614_+	phage protein	A0A286QMU5	Streptococcus_phage	1.5e-37	84.9
VED88002.1\|687610_688015_+	phage protein	A0A286QNB5	Streptococcus_phage	3.7e-20	39.3
VED88004.1\|688007_688712_+	Protein of uncharacterised function (DUF1340)	F8HGR9	Streptococcus_phage	1.5e-93	72.7
VED88006.1\|689050_689473_+	Uncharacterised protein	NA	NA	NA	NA
VED88008.1\|689555_690038_+\|terminase	putative terminase small subunit	A0A286QNY9	Streptococcus_phage	2.2e-64	84.5
VED88010.1\|690024_691329_+\|terminase	putative phage terminase large subunit	A0A286QNX6	Streptococcus_phage	3.7e-223	87.8
VED88012.1\|691340_692849_+\|capsid	Minor capsid protein	C5IUJ2	Streptococcus_phage	5.1e-264	91.6
VED88014.1\|692855_694046_+\|capsid	phage minor capsid 2 family protein	A0A286QMS2	Streptococcus_phage	2.1e-124	55.4
VED88016.1\|694243_694861_+	putative scaffolding protein	A0A286QP26	Streptococcus_phage	1.3e-77	80.5
VED88018.1\|694869_695715_+	MHP	A0A286QMT1	Streptococcus_phage	1.5e-140	91.5
VED88020.1\|695714_695900_+	transcription termination factor	A0A286QMS5	Streptococcus_phage	1.5e-16	73.8
VED88022.1\|695918_696308_+	phage protein	C5IUJ7	Streptococcus_phage	2.4e-56	83.7
VED88024.1\|696297_696633_+\|capsid	putative minor capsid protein 2	A0A286QMS6	Streptococcus_phage	6.3e-34	61.3
VED88026.1\|696632_697028_+\|capsid	putative minor capsid protein	A0A1S5SA80	Streptococcus_phage	1.5e-29	55.6
VED88028.1\|697027_697432_+	phage protein	A0A286QML6	Streptococcus_phage	1.5e-53	77.6
VED88029.1\|697432_698011_+\|tail	tail shaft protein	A0A286QNY7	Streptococcus_phage	1.8e-76	85.4
VED88044.1\|698101_698464_+	Uncharacterised protein	A0A286QNZ4	Streptococcus_phage	2.3e-37	67.8
VED88046.1\|698466_699081_+	phage protein	A0A286QMS7	Streptococcus_phage	1.6e-86	72.7
VED88048.1\|699097_703705_+	phage protein	C5IUK3	Streptococcus_phage	2.1e-228	88.2
VED88050.1\|703701_704430_+	prophage Lp1 protein 51	A0A286QMT6	Streptococcus_phage	1.0e-108	76.9
VED88052.1\|704426_706292_+	putative membrane metallo-endo-peptidase	C5IUK5	Streptococcus_phage	1.2e-166	57.8
VED88054.1\|706291_708463_+	pectinesterase	A0A1S5SA51	Streptococcus_phage	5.8e-277	65.6
VED88056.1\|708474_708909_+\|holin	putative holin	F8HGP0	Streptococcus_phage	1.4e-57	81.6
VED88058.1\|708901_709132_+\|holin	holin	A0A2I6QR05	Streptococcus_phage	1.4e-29	89.5
VED88060.1\|709134_709587_+	phage protein	A0A2I6QR28	Streptococcus_phage	1.1e-70	89.3
VED88062.1\|709599_709926_+	Uncharacterised protein	A0A2H4J011	uncultured_Caudovirales_phage	2.2e-39	78.7
VED88064.1\|709938_710211_+	Uncharacterised protein	A0A2H4J827	uncultured_Caudovirales_phage	3.0e-26	83.1
VED88066.1\|710229_711615_+	Phage lysin, N-acetylmuramoyl-L-alanine amidase	A0A286QS50	Streptococcus_phage	3.0e-247	90.0
VED88068.1\|712752_712938_-\|tRNA	Isoleucyl-tRNA synthetase, putative	W6LMT3	Streptococcus_phage	1.9e-24	93.4
712557:712600	attR	NA	NA	NA	NA
VED88070.1\|713112_715299_-	glycerol phosphate lipoteichoic acid synthase 2	W6LM83	Streptococcus_phage	0.0e+00	95.3
VED88072.1\|715460_716624_+	methyltransferase	W6LLI2	Streptococcus_phage	1.7e-211	94.6
VED88074.1\|716620_717298_+	3-dehydroquinate dehydratase	W6LP76	Streptococcus_phage	3.3e-114	92.9
VED88076.1\|717287_718145_+	shikimate 5-dehydrogenase	NA	NA	NA	NA
VED88078.1\|718157_719225_+	3-dehydroquinate synthase	NA	NA	NA	NA
VED88080.1\|719225_720392_+	chorismate synthase	A0A291AU41	Pandoravirus	9.3e-40	34.9
VED88082.1\|720421_721528_+	prephenate dehydrogenase	NA	NA	NA	NA
VED88084.1\|721537_721876_+	putative transcriptional regulator	A0A1X9I5Y8	Streptococcus_phage	2.1e-21	47.7
VED88086.1\|721964_722915_+	L-2-hydroxyisocaproate dehydrogenase	NA	NA	NA	NA
VED88088.1\|722995_724279_+	3-phosphoshikimate 1-carboxyvinyltransferase	NA	NA	NA	NA
VED88090.1\|724271_724763_+	shikimate kinase	NA	NA	NA	NA
VED88093.1\|724753_725578_+	prephenate dehydratase	NA	NA	NA	NA
VED88095.1\|725589_727011_+	cell envelope-like function transcriptional attenuator common domain protein	NA	NA	NA	NA
VED88097.1\|727025_727964_-	Exfoliative toxin A	NA	NA	NA	NA
VED88099.1\|727980_729045_-	Acyl-CoA dehydrogenase, short-chain specific	NA	NA	NA	NA
VED88101.1\|729084_729633_-	Macrophage infectivity potentiator protein	NA	NA	NA	NA
VED88103.1\|729846_731205_+	23S rRNA-methyltransferase	F5CA72	Streptococcus_phi-m46.1-like_phage	2.8e-205	79.6
VED88105.1\|731679_732000_+	TfoX domain family protein	NA	NA	NA	NA
VED88107.1\|732028_732418_+	glyoxalase	NA	NA	NA	NA
VED88109.1\|732554_733397_+	AraC family transcriptional regulator	D0R0F8	Streptococcus_phage	5.5e-127	80.6
VED88111.1\|733881_734415_+	GCN5-related N-acetyl transferase	NA	NA	NA	NA
VED88113.1\|734666_735236_+	Uncharacterised protein	NA	NA	NA	NA
VED88116.1\|735476_736265_-	abortive infection protein	NA	NA	NA	NA
VED88118.1\|736269_737157_-	transcriptional regulator	A0A0A7AQV8	Bacillus_phage	1.1e-05	30.4
VED88121.1\|737452_738229_+	alpha/beta superfamily hydrolase	NA	NA	NA	NA
VED88123.1\|738292_739465_-	major facilitator family transporter	NA	NA	NA	NA
VED88125.1\|739694_740537_-	DegV family protein	A0A1X9I5J4	Streptococcus_phage	1.7e-107	69.9
VED88127.1\|740662_741232_+	TetR family transcriptional regulator	A0A1X9I6A2	Streptococcus_phage	2.7e-16	47.8
VED88129.1\|741268_741904_+	copper homeostasis protein CutC	NA	NA	NA	NA
VED88131.1\|742027_742300_+	Uncharacterised protein	NA	NA	NA	NA
VED88133.1\|742466_743306_+	membrane associated lipoprotein	NA	NA	NA	NA
VED88135.1\|743355_744105_+\|protease	CAAX amino protease family protein	NA	NA	NA	NA

DBSCAN-SWA_3

1222109 : 1230054

Streptococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VED88956.1\|1222109_1223129_-	alcohol dehydrogenase 1 (Alcohol dehydrogenase I) (ADH I)	A0A2K9L339	Tupanvirus	1.0e-26	25.5
VED88958.1\|1223289_1223571_-	Uncharacterised protein	M1PG86	Streptococcus_phage	1.6e-22	58.4
VED88959.1\|1223548_1223926_-	Uncharacterised protein	A0A1B0RXA8	Streptococcus_phage	2.0e-20	45.8
VED88961.1\|1223922_1225338_-	SOS responce UmuC protein	M1Q231	Streptococcus_phage	1.0e-194	70.7
VED88963.1\|1225451_1226303_-	amino acid ABC transporter substrate-binding protein	NA	NA	NA	NA
VED88965.1\|1226315_1226945_-	glutamine transport ATP-binding protein GlnQ	G3M9Y6	Bacillus_virus	1.3e-32	40.7
VED88967.1\|1226953_1227595_-	ABC transporter permease	NA	NA	NA	NA
VED88969.1\|1227795_1228128_-	putative alkylphosphonate utilization operon protein PhnA	NA	NA	NA	NA
VED88971.1\|1228245_1230054_-	glucosamine-fructose-6-phosphate aminotransferase	A7IW18	Paramecium_bursaria_Chlorella_virus	2.5e-100	39.4

DBSCAN-SWA_4

2004984 : 2062477

Lactococcus_phage(22.22%)

tRNA,protease,transposase,bacteriocin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VED90116.1\|2004984_2005275_-\|transposase	transposase of family protein	A0A1P8BMC0	Lactococcus_phage	2.5e-10	39.0
VED90118.1\|2005651_2006065_-	esterase	NA	NA	NA	NA
VED90120.1\|2006082_2006418_-	thioredoxin domain containing protein	NA	NA	NA	NA
VED90123.1\|2017746_2018889_-\|tRNA	queuine tRNA-ribosyltransferase	A0A1B1IVQ4	uncultured_Mediterranean_phage	9.3e-85	42.8
VED90125.1\|2019193_2019484_-\|transposase	transposase of family protein	A0A1P8BMC0	Lactococcus_phage	2.5e-10	39.0
VED90126.1\|2019867_2020002_-	LSU ribosomal protein L34p	NA	NA	NA	NA
VED90127.1\|2020197_2020761_-	Flavodoxin-like fold protein	NA	NA	NA	NA
VED90129.1\|2020757_2021354_-	putative transcriptional regulator	NA	NA	NA	NA
VED90130.1\|2021483_2022527_-	r3H domain protein	NA	NA	NA	NA
VED90131.1\|2022538_2023393_-	preprotein translocase subunit YidC	NA	NA	NA	NA
VED90132.1\|2023460_2023796_-	ribonuclease P protein component	NA	NA	NA	NA
VED90134.1\|2023880_2025266_-	argininosuccinate lyase	NA	NA	NA	NA
VED90135.1\|2025592_2026792_-	argininosuccinate synthase	NA	NA	NA	NA
VED90136.1\|2027737_2028481_-	response regulator FasA	NA	NA	NA	NA
VED90138.1\|2028482_2029799_-	putative histidine kinase	NA	NA	NA	NA
VED90139.1\|2029822_2031103_-	sensor histidine kinase	NA	NA	NA	NA
VED90140.1\|2031124_2032015_-	putative histidine kinase of the competence regulon, ComD	NA	NA	NA	NA
VED90142.1\|2032074_2033382_-	putative histidine kinase of the competence regulon, ComD	NA	NA	NA	NA
VED90143.1\|2033834_2035289_-\|tRNA	glutamyl-tRNA synthetase	NA	NA	NA	NA
VED90145.1\|2035524_2037495_-	oligopeptide binding protein 3	NA	NA	NA	NA
VED90147.1\|2037675_2038365_-	50S ribosomal protein L1	NA	NA	NA	NA
VED90149.1\|2038464_2038890_-	50S ribosomal protein L11	NA	NA	NA	NA
VED90152.1\|2039061_2039415_+	integral membrane protein	NA	NA	NA	NA
VED90154.1\|2039510_2040008_-	carbonate dehydratase	NA	NA	NA	NA
VED90156.1\|2040158_2040854_-	HTH DNA-binding protein	NA	NA	NA	NA
VED90158.1\|2040939_2042187_-	DNA repair protein	NA	NA	NA	NA
VED90160.1\|2042297_2042816_-	Isochorismatase family	NA	NA	NA	NA
VED90162.1\|2042775_2043222_-	deoxyuridine 5'-triphosphate nucleotidohydrolase	Q332E8	Clostridium_botulinum_C_phage	8.5e-34	50.7
VED90163.1\|2043429_2044032_+	NADPH-dependent fmn reductase	A0A2P0ZL77	Lactobacillus_phage	2.0e-54	53.7
VED90165.1\|2044050_2045301_+	flavin reductase	A0A2P0ZL82	Lactobacillus_phage	7.6e-56	52.7
VED90167.1\|2045534_2046212_+	formate/nitrite transporter family protein	NA	NA	NA	NA
VED90168.1\|2046220_2046781_+	membrane-bound protein	NA	NA	NA	NA
VED90169.1\|2046899_2047922_+	glycerol-3-phosphate dehydrogenase [NAD(P)+]	NA	NA	NA	NA
VED90170.1\|2047939_2048854_+	UTP--glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (Alpha-D-glucosyl-1-phosphate uridylyltransferase) (Uridine diphosphoglucose pyrophosphorylase)	A0A127AW70	Bacillus_phage	3.7e-76	51.5
VED90171.1\|2048899_2049574_-	peptidase, S54 family	NA	NA	NA	NA
VED90172.1\|2049564_2050092_-	5-formyltetrahydrofolate cyclo-ligase	NA	NA	NA	NA
VED90173.1\|2050160_2051294_-	aminoacylase/N-acyl-L-amino acid amidohydrolase/hippurate hydrolase	NA	NA	NA	NA
VED90174.1\|2051370_2052069_-	2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase	NA	NA	NA	NA
VED90175.1\|2052154_2052907_-	haloacid dehalogenase-like hydrolase	NA	NA	NA	NA
VED90176.1\|2053020_2053860_-	methyltransferase domain protein	NA	NA	NA	NA
VED90177.1\|2054281_2054440_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
VED90178.1\|2054459_2054627_+\|bacteriocin	class IIb bacteriocin, lactobin A/cerein 7B family	NA	NA	NA	NA
VED90179.1\|2054674_2054929_+	Uncharacterised protein	NA	NA	NA	NA
VED90180.1\|2055013_2055532_-\|tRNA	tRNA-specific adenosine deaminase	NA	NA	NA	NA
VED90181.1\|2056291_2056684_-	single-strand binding protein	A1EAD1	Streptococcus_phage	2.6e-26	47.7
VED90182.1\|2057112_2057790_-\|protease	CAAX amino protease family protein	NA	NA	NA	NA
VED90183.1\|2058056_2058680_-	emap domain protein	NA	NA	NA	NA
VED90184.1\|2058711_2059236_-	Uncharacterised protein	NA	NA	NA	NA
VED90185.1\|2059239_2059554_-	thioredoxin	NA	NA	NA	NA
VED90186.1\|2059550_2059835_-	Uncharacterised protein	NA	NA	NA	NA
VED90187.1\|2059934_2061002_+	glutamyl aminopeptidase	NA	NA	NA	NA
VED90188.1\|2061017_2061788_+	pyrroline-5-carboxylate reductase	A0A1X9I6T5	Streptococcus_phage	6.2e-32	35.4
VED90189.1\|2061814_2062477_-\|protease	CAAX amino protease family protein	NA	NA	NA	NA

DBSCAN-SWA_5

2183639 : 2195070

Staphylococcus_phage(25.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VED90321.1\|2183639_2184335_-	immunodominant antigen A precursor	Q4Z8Z7	Staphylococcus_phage	5.9e-26	72.4
VED90322.1\|2184518_2185100_-	LysM domain-containing protein	A0A249XZV3	Enterococcus_phage	1.0e-23	55.2
VED90323.1\|2185400_2186195_-	cobalt ABC transporter permease CbiQ-like protein	NA	NA	NA	NA
VED90324.1\|2186187_2187030_-	cobalt import ATP-binding protein CbiO 1	A0A2H4PQG7	Staphylococcus_phage	6.3e-14	27.9
VED90325.1\|2187005_2187836_-	cobalt import ATP-binding protein CbiO 2	G9BWD6	Planktothrix_phage	1.8e-21	32.7
VED90326.1\|2187848_2188391_-	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	NA	NA	NA	NA
VED90327.1\|2188403_2189261_-	XRE-family DNA-binding domain-containing protein	NA	NA	NA	NA
VED90328.1\|2189319_2190597_-	peptidase	A0A2H4UVM3	Bodo_saltans_virus	1.5e-06	28.1
VED90329.1\|2190598_2191849_-	peptidase M16 inactive domain protein	A0A1X9I714	Streptococcus_phage	6.6e-92	40.3
VED90330.1\|2191926_2192304_+	S4 domain-containing protein YaaA	A0A1X9I5V8	Streptococcus_phage	3.9e-24	72.4
VED90331.1\|2192306_2193407_+	DNA replication and repair protein RecF	NA	NA	NA	NA
VED90332.1\|2193588_2195070_-	inositol-5-monophosphate dehydrogenase	A0A1V0SHK8	Klosneuvirus	2.6e-95	40.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. LR134274

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection