CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
LR134326	Bordetella bronchiseptica strain NCTC10543 genome assembly, chromosome: 1	6 crisprs	cas3,DinG,DEDDh,csa3,WYL	1	0	1	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: LR134326_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134326_1

496184-496267

Orphan

Consensus_repeat	Method
CTGTCCCCGCGGGGACAGGCACC	CRISPRCasFinder

1 spacers

The CRISPR arrays of LR134326_1

>merge|LR134326|1|496184-496267|CRISPRCasFinder
CTGTCCCCGCGGGGACAGGCACCCCGTCATACGCCAGAACGCTTGACGGCCAAGACGGTATCTGTCCCCGCGGGGACAGGCACC

>LR134326|1|1|496184-496267|CRISPRCasFinder
CTGTCCCCGCGGGGACAGGCACC	CCGTCATACGCCAGAACGCTTGACGGCCAAGACGGTAT
CTGTCCCCGCGGGGACAGGCACC

Protein	Signature genes	Signature genes Name	Protein_function
LR134326.1\|VEF39582.1\|501166_502039_-\|glmZ(sRNA)-inactivating-NTPase	unknown	unknown	gnl\|CDD\|235450
LR134326.1\|VEF39572.1\|493430_494177_-\|phosphoglycolate-phosphatase	unknown	unknown	gnl\|CDD\|319791
LR134326.1\|VEF39577.1\|497513_498116_-\|Phosphoheptose-isomerase	unknown	unknown	gnl\|CDD\|237567
LR134326.1\|VEF39567.1\|486922_488875_+\|Penicillin-binding-protein-2	unknown	unknown	gnl\|CDD\|274573
LR134326.1\|VEF39584.1\|502973_504260_+\|Alcohol-dehydrogenase-cytochrome-c-subunit-precursor	unknown	unknown	gnl\|CDD\|365823
LR134326.1\|VEF39566.1\|486345_486909_+\|Rod-shape-determining-protein-mreD	unknown	unknown	gnl\|CDD\|274574
LR134326.1\|VEF39574.1\|495340_496129_+\|D-methionine-binding-lipoprotein-metQ-precursor	unknown	unknown	gnl\|CDD\|224381
LR134326.1\|VEF39576.1\|496773_497514_-\|Osmotically-inducible-protein-Y-precursor	unknown	unknown	gnl\|CDD\|182907
LR134326.1\|VEF39579.1\|498715_499654_+\|Ribosomal-RNA-small-subunit-methyltransferase-I	unknown	unknown	gnl\|CDD\|223390
LR134326.1\|VEF39583.1\|502054_502963_+\|Cytochrome-c4-precursor	unknown	unknown	gnl\|CDD\|225418
LR134326.1\|VEF39578.1\|498115_498649_-\|Uncharacterised-protein-family-UPF0102	unknown	unknown	gnl\|CDD\|173148
LR134326.1\|VEF39568.1\|488871_490008_+\|Rod-shape-determining-protein-RodA	unknown	unknown	gnl\|CDD\|274033
LR134326.1\|VEF39580.1\|499650_500223_+\|Methylated-DNA--protein-cysteine-methyltransferase,-constitutive	unknown	unknown	gnl\|CDD\|223427
LR134326.1\|VEF39581.1\|500219_501170_-\|RlpA-like-protein-precursor	unknown	unknown	gnl\|CDD\|223868
LR134326.1\|VEF39571.1\|492805_493381_-\|Synthetically-lethal-with-a-defective-Min-system-protein-A	unknown	unknown	gnl\|CDD\|181894
LR134326.1\|VEF39575.1\|496285_496777_-\|Thiol-disulfide-oxidoreductase-resA	unknown	unknown	gnl\|CDD\|239264
LR134326.1\|VEF39569.1\|490033_491089_-\|L-lactate-dehydrogenase	unknown	unknown	gnl\|CDD\|376860
LR134326.1\|VEF39573.1\|494176_495079_-\|Acetylglutamate-kinase	unknown	unknown	gnl\|CDD\|234869
LR134326.1\|VEF39570.1\|491099_492593_-\|Inner-membrane-protein-ybhI	unknown	unknown	gnl\|CDD\|279307
LR134326.1\|VEF39565.1\|485474_486359_+\|rod-shape-determining-protein-MreC	unknown	unknown	gnl\|CDD\|237560

Protein	Function_ID	Function_description	E-value
LR134326.1\|VEF39582.1\|501166_502039_-\|glmZ(sRNA)-inactivating-NTPase	gnl\|CDD\|235450	PRK05416, PRK05416, RNase adapter RapZ.	1.18739e-149
LR134326.1\|VEF39572.1\|493430_494177_-\|phosphoglycolate-phosphatase	gnl\|CDD\|319791	cd02604, HAD_5NT, haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to Saccharomyces cerevisiae Phm8p and Sdt1p. This family includes Saccharomyces cerevisiae Phm8p (phosphate metabolism protein 8) and Sdt1p (Suppressor of disruption of TFIIS). Phm8p participates in the ribose salvage pathway, it catalyzes the dephosphorylation of nucleotide monophosphates to nucleosides, its preferred substrates are nucleotide monophosphates AMP, GMP, CMP, and UMP. Phm8p is also a lysophosphatidic acid phosphatase, dephosphorylating lysophosphatidic acids (LPAs) to monoacylglycerol in response to phosphate starvation. Sdt1p is a pyrimidine and pyridine-specific 5'-nucleotidase; it is an NMN/NaMN 5'-nucleotidases involved in the production of nicotinamide riboside and nicotinic acid riboside, and is a pyrimidine 5'-nucleotidase with high specificity for UMP and CMP. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.14842e-46
LR134326.1\|VEF39577.1\|497513_498116_-\|Phosphoheptose-isomerase	gnl\|CDD\|237567	PRK13936, PRK13936, phosphoheptose isomerase; Provisional.	1.25469e-125
LR134326.1\|VEF39567.1\|486922_488875_+\|Penicillin-binding-protein-2	gnl\|CDD\|274573	TIGR03423, pbp2_mrdA, penicillin-binding protein 2. Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	0
LR134326.1\|VEF39584.1\|502973_504260_+\|Alcohol-dehydrogenase-cytochrome-c-subunit-precursor	gnl\|CDD\|365823	pfam00034, Cytochrom_C, Cytochrome c. The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.	4.18466e-10
LR134326.1\|VEF39566.1\|486345_486909_+\|Rod-shape-determining-protein-mreD	gnl\|CDD\|274574	TIGR03426, shape_MreD, rod shape-determining protein MreD. Members of this protein family are the MreD protein of bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. It is highly hydrophobic (therefore somewhat low-complexity) and highly divergent, and therefore sometimes tricky to discover by homology, but this model finds most examples. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan].	7.62373e-19
LR134326.1\|VEF39574.1\|495340_496129_+\|D-methionine-binding-lipoprotein-metQ-precursor	gnl\|CDD\|224381	COG1464, NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism].	1.17353e-136
LR134326.1\|VEF39576.1\|496773_497514_-\|Osmotically-inducible-protein-Y-precursor	gnl\|CDD\|182907	PRK11023, PRK11023, divisome-associated lipoprotein YraP.	1.47763e-42
LR134326.1\|VEF39579.1\|498715_499654_+\|Ribosomal-RNA-small-subunit-methyltransferase-I	gnl\|CDD\|223390	COG0313, COG0313, Predicted methyltransferases [General function prediction only].	6.87023e-109
LR134326.1\|VEF39583.1\|502054_502963_+\|Cytochrome-c4-precursor	gnl\|CDD\|225418	COG2863, COG2863, Cytochrome c553 [Energy production and conversion].	1.01131e-12
LR134326.1\|VEF39578.1\|498115_498649_-\|Uncharacterised-protein-family-UPF0102	gnl\|CDD\|173148	PRK14685, PRK14685, hypothetical protein; Provisional.	3.44426e-89
LR134326.1\|VEF39568.1\|488871_490008_+\|Rod-shape-determining-protein-RodA	gnl\|CDD\|274033	TIGR02210, Rod_shape-determining_protein_RodA, rod shape-determining protein RodA. This protein is a member of the FtsW/RodA/SpoVE family (pfam01098). It is found only in species with rod (or spiral) shapes. In many species, mutation of rodA has been shown to correlate with loss of the normal rod shape. Note that RodA homologs are found, scoring below the cutoffs for this model, in a number of both rod-shaped and coccoid bacteria, including four proteins in Bacillus anthracis, for example. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Cell division].	3.23854e-160
LR134326.1\|VEF39580.1\|499650_500223_+\|Methylated-DNA--protein-cysteine-methyltransferase,-constitutive	gnl\|CDD\|223427	COG0350, Ada, Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair].	7.98182e-54
LR134326.1\|VEF39581.1\|500219_501170_-\|RlpA-like-protein-precursor	gnl\|CDD\|223868	COG0797, RlpA, Lipoproteins [Cell envelope biogenesis, outer membrane].	3.79567e-55
LR134326.1\|VEF39571.1\|492805_493381_-\|Synthetically-lethal-with-a-defective-Min-system-protein-A	gnl\|CDD\|181894	PRK09480, slmA, division inhibitor protein; Provisional.	1.59741e-107
LR134326.1\|VEF39575.1\|496285_496777_-\|Thiol-disulfide-oxidoreductase-resA	gnl\|CDD\|239264	cd02966, TlpA_like_family, TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a CXXC motif located in the periplasm. The TRX domains of this family contain an insert, approximately 25 residues in length, which correspond to an extra alpha helix and a beta strand when compared with TRX. TlpA catalyzes an essential reaction in the biogenesis of cytochrome aa3, while ResA and DsbE are essential proteins in cytochrome c maturation. Also included in this family are proteins containing a TlpA-like TRX domain with domain architectures similar to E. coli DipZ protein, and the N-terminal TRX domain of PilB protein from Neisseria which acts as a disulfide reductase that can recylce methionine sulfoxide reductases.	1.58284e-41
LR134326.1\|VEF39569.1\|490033_491089_-\|L-lactate-dehydrogenase	gnl\|CDD\|376860	pfam02615, Ldh_2, Malate/L-lactate dehydrogenase. This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyzes the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyzes the reactions: (S)-malate + NAD(+) <=> oxaloacetate + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively.	1.11307e-125
LR134326.1\|VEF39573.1\|494176_495079_-\|Acetylglutamate-kinase	gnl\|CDD\|234869	PRK00942, PRK00942, acetylglutamate kinase; Provisional.	1.71108e-158
LR134326.1\|VEF39570.1\|491099_492593_-\|Inner-membrane-protein-ybhI	gnl\|CDD\|279307	pfam00939, Na_sulph_symp, Sodium:sulfate symporter transmembrane region. There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.	2.68833e-115
LR134326.1\|VEF39565.1\|485474_486359_+\|rod-shape-determining-protein-MreC	gnl\|CDD\|237560	PRK13922, PRK13922, rod shape-determining protein MreC; Provisional.	9.0892e-90

>LR134326.1|VEF39574.1|495340_496129_+|D-methionine-binding-lipoprotein-metQ-precursor
MRMNFVRSALLASAFLLAGGAAQAEKLVVGATQVPHAEILEVVKPALAKEGVELDIKVFTDYVQPNLQLADKQLDANFFQHQPYLDTFNKDRKTNLVSVGLVHVEPFGGYSKKIKSLAELKDGATIAIPNDPSNSGRALLLLQKQGLLKLKDPSNIVATPIDIAENPKKLKFRELEAAMLPRSLDDLDLALINTNYALEAGLVPTRDALFIEGADSPYANLVAARPDNKDAPAVKKLVNALHSEAVRKFIIEKYKGAVVPAF
>LR134326.1|VEF39573.1|494176_495079_-|Acetylglutamate-kinase
MTDTPDPAAVLSPAVKAAVLSEALPYIRRFHGKTIVVKYGGNAMTEERLQRSFAHDVVLLKLVGLNPVVVHGGGPQIDDALRRIGKQGTFVQGMRVTDAETMEVVEWVLGGQVQQDIVMMINEVGGKAVGLTGKDGMLIQATKKLMVNKDDPSQPLDIGFVGDITRVEPAVVKALQDDQFIPVISPIGYGEDGTAYNINADVVAGKMAEVLGAEKLLMMTNTPGVLDKGGKLLRSLSAQTIDELFADGTISGGMLPKISSSLDAAKNGVNSVHIVDGRVPHCLLLEILTDQGVGTMISSH
>LR134326.1|VEF39572.1|493430_494177_-|phosphoglycolate-phosphatase
MQARRYLLRPAARLRRSRRIATAAPERLWLFDLDNTLHDTSHAIFPLIDRGMTEAVAETLAVDEATANRLRAEYWRRYGATVIGLVRHHGVDADAFLHRSHNFEVAPLVRAETALADKLRRLPGRKVLLTNAPLHYARAVLRHLGLLRQFDSIWAIEQMRMHGQFRPKPSDALLRYVLAREGVPAARAVLIEDTLDNLRSARRVGLRTVHVFHPGTPFARGHRQRPGYVDLRVNSVSDLLLRRRPLRG
>LR134326.1|VEF39571.1|492805_493381_-|Synthetically-lethal-with-a-defective-Min-system-protein-A
MASKPGERKTQILHTLAEMLEQPHAARITTSALAARMQVSEAALYRHFASKAQMFEGLIEFIETSIFTVVNQIAVSEPYGMGQARKTVAMLLAFAERNRGITRVLTGDALVTEDNRLQERINHINDRIEASLKQCLRVAVSDGALPADANIAAHASLLTHLVLGRWLRYAQSGWRVAPTTHLEEHLRLALG
>LR134326.1|VEF39570.1|491099_492593_-|Inner-membrane-protein-ybhI
MTAPAAVPAPQSPPKVKIPIGLIAGIIAMVVVLLLPLPAELPPAGHRMLAILAFAVVVWITEAVSYEASAIMITTLMAFLLGTAPNVKNPDVLYGTSAAISMALTGFSNSALALVTGALFIAAAMTFTGLDKRIALVTLARVGTSTRRILLGAIAVTIVLSLVVPSATARSAAVVPIMLGVIAAFGVDKRSNIAAGIMIIVAQATSIWNVGIQTAAAQNLLTVGFMDKMLGERVAWSDWLIAGVPWSLLMSAVLIFVVLRLLPPESDAIAGGKEAVEASLRELGPMTSAQKRLMLVSIMLLLFWSTEGKLHKFDTTSTTYFGLVLLMLPRFGVMTWKDVQTRIPWGTVIVFGVGISLGTALLTTQAGQWLGAQVVAHTGLDHLGPLGIFAILSAFLILIHLGFASATALTSAMLPILIAVLQTLPGDFNRLGMTMLLGFVVSYGFILPINAPQNMVALGTETFTAKQFAKVGIVLTIVGYLLMLLMSVTYWRWLGWM
>LR134326.1|VEF39569.1|490033_491089_-|L-lactate-dehydrogenase
MKLSIAQAIAFGQRLLAAQGVPDDIARDVAEHLVESDRVGYTSHGLSILPNYRRVLAEGFVKADGRARLLNDRGAMLAFDGDNGFGQHVGKAVMQQAIERARQYGQCIVTLRRTHHLGRMGYYGEMAAEAGLILLAFTNVVNRPPTVAPYGGAQACLTTNPLCFAGPLPGGRPPFLVDMATSSIAVNKARVLAARGEPAPDGALIDAQGNPTNDPNALFADPPGALLPFGGHKGYAMGLVAELLAGVLSGGGTIQPEHPRNGVATNNMFAILLDPQVDFNADWRTQEVGAFIDYLHACPPQPGVDRVQYPGEYEAMNRARHAEAIEFEGAIWDSLAKLAQDLGAADALPRA
>LR134326.1|VEF39568.1|488871_490008_+|Rod-shape-determining-protein-RodA
MKRLGLILLRVFTAFDWPLLLILILFTLLGLTVMHSAVGSTDWRFAEQSRNFLIAFAAMWAMALVPPNTLMKLALPFYVLGVILLLGVEFFGETSKGATRWLNLGVTRIQPSEMMKIAVPMMLAWYFQRHDGAVRIRDFFVAAAMLAAPFVLIVLQPDLGTALLVFGAGFFVIYFAGLSFKLLVPCLLAGIIAIGTLIYYEDQLCEPEVDWVVLHDYQKHRVCTLLNPSSDPLGKGFHTIQSMIAVGSGGLYGKGYMQGTQTHLDFIPERTTDFIFAVYAEEFGLYGGVALLVLYGLFMARGLAIASRASSQFGRLLAGAITMMMFIYVFVNVGMVTGILPVVGVPLPFMSYGGTALLTMGIACGILMSISRRRPAPA
>LR134326.1|VEF39567.1|486922_488875_+|Penicillin-binding-protein-2
MFEFKKTGQQQKQRFRLRAWVGGLFALACFGVLAGRFWYLQVDRYEGFSERADRNRIAVVPIPPRRGEILDRNGEVLARNYRTYTLEVVPAQAGNLDQLFDRLARVVYISPSDQRRFKRRVGESSRYASLQLRNNLNDTEAAWFSAHSFEFPGVELRARWVREYPQGEAAAHVVGFIGRIAENDIEELDKAGQLGNYRGTDVIGKKGIEKTWEAALHGRTGLEEVEVTAGGRPMRTLRRIDPVPGSDIMLSIDLELQKLAEQAFEGRRGALVALDPDTGEVLAFVSQPSFDPNLFVDGIDVENWRRLNESPDHPLINRPLYGTYPIGSTYKPFVALAALELGKRRATDRMPDPGYFEFGGQKFRNAGGAAYGMTDMHRAIVVSSDTYFYSLGPEIGVNALHDFSKQFGFGQITGIDLEGEKAGVLPSTEWKRKAYKDRDRQRWYAGETISVAVGQGYNSFTLLQLAQATSTLANSGLYRRPHLVHAIRDSRSGSVNPTEIAPDYRIPLKQENVDVIKRAMADVVRAGTARRAFAGAPYQAAGKTGTAQVFSLRGGQYRASAIDERLRDHALFMGFAPVEQPRIAVALIVENAGWGASAAAPIARTLFDNWLGRADAPSVVRAGAKPVAAEPEAAALELGATDGPMQERRQ
>LR134326.1|VEF39566.1|486345_486909_+|Rod-shape-determining-protein-mreD
MERTKVSVPARRKLGTPSNVEPERLARPAHGVFVWGTVLLVWLLSLLPWRQWPGSPDVLVLVIAFWCVHEPRRVGLLTAFVFGLLLDVHDAGLLGGHALSYTLTAYGAIALHRRLQRFDLWSQAMHMLPVFFLAQLVTQIILAWLAGKWPGWQWAVSVGLTVAIWPLAGWVLHMPQRRYDDVESSAV
>LR134326.1|VEF39565.1|485474_486359_+|rod-shape-determining-protein-MreC
MQRQATPPLFRRGPPAEVRLAVLVILALALLIVDSQLRVLEPVRRAVSVALYPFQRAVMAPRDLVQQVDEWINAASLIRSENEALQRQRIELAQVATHAAQLAAENAQLRRLLGVTDTVAQSAVVVEVLYEPPNAFHQRLVFNKGAKSGLAPGMPVIDEGGVVGQIVRVTPMTAEAALVTDERVSIPVQVLRNGLRLIAFGANTPGVIEVRYLAANADIKVGDTIVTSGVGGLFPAGLPVAKVASVERDTASGFARALGEPLAHPERYRHFLVLQVDVDQAESNRQEADVDGAD
>LR134326.1|VEF39575.1|496285_496777_-|Thiol-disulfide-oxidoreductase-resA
MKKIALVLIIAVAAGIGGWFMWRPAQTAPDVAFTTLEGQKITMQDLRGKVVLVKFWATSCVTCVKQMPDNIANYNQYHPQGYETIAVAMNYDPPNYVLNFAQTRKLPFPVALDTSGELAQAFGNVRLTPTAFLIDKQGQIIKRYLGEYDKAEFQATVQKALAG
>LR134326.1|VEF39576.1|496773_497514_-|Osmotically-inducible-protein-Y-precursor
MPDAKTAARPLLLAAALSAAALTLSACAPLVIGGAAATTAVVVTDRRTSGVQLEDQNIAFKAESQIAQKLGNTARVNAMVYGGHVLLTGDAPTEEAKAQATAIAQSIENVKAVTNQLTVGPAADFSTRSNDTWLTSKVKTALINTKYVPSGTISVTTSRGVVYLMGKVTQAEGDYAANAAAGVGGVARVVKLFETISREEAIRLSGSGTKSGEGSSDGTAAQKAPIESGAAPAGSGSNGVEAIPIK
>LR134326.1|VEF39577.1|497513_498116_-|Phosphoheptose-isomerase
MRAMDMTSRMTSHFRDAMALCEQSADALAAPLAAAVDLLFAALANNGRILACGNGGSAADAQHFIAELVGRFERERLPLAGIALNTDTSIMTAVGNDYGFDEIFERQVHALGQPGDVLVAISTSGNSPNVVRAMETAREREMHVIALTGKGGGVMGELITPHDVHLCVPHDRTMRIQEVHIILLHALCDGIDALLLGDTE
>LR134326.1|VEF39578.1|498115_498649_-|Uncharacterised-protein-family-UPF0102
MTDTATHLAFARAAQAQRRLHRRPPASPRASPGARDGGSPTQRRGQAYESAALRWLARQGLRPLARNLRCRAGEIDLAMRDGEVLVLVEVRARAHAGYGGAAASIGASKQGRLARAAALLLPVLLRRYWPGAPPPVRFDVVAFEAGRPHWLRGAFWLAEHAPAQGRRGQDAQGWRVR
>LR134326.1|VEF39579.1|498715_499654_+|Ribosomal-RNA-small-subunit-methyltransferase-I
MNQDVLSPTPGDAWSRVADRVAAQHWPAATLYVIATPIGNLGDLGLRAWQALVRADVIAAEDTRASRTLLDAWGVSTPLMAAHRHNEASAAQAICERLAQGQRVALVSDAGAPAVSDPGARIVRAVREAGYAVVPVPGPSAVIAALMGSGATSDENPAFAFAGFPPAKAVARQRWLRQWCALPAPVVMFESPHRLAATLADLREAGGPARLLTVARELTKRFEEIATMPLGEAADWLAADAHRGQGEFVLIVHQAPGAQDDEADPADPRTDALLDALLESLSVRDAARVAAKVTGLARDVLYARALARKEQP
>LR134326.1|VEF39580.1|499650_500223_+|Methylated-DNA--protein-cysteine-methyltransferase,-constitutive
MNPPSEQATDILYCDTDTPLGPMRLAARGQALCGAWFVDQRDCPAAAGWTPDAAHPALRQAAAELEQWFAGRRRAFEVDMQPEGTPFQRQVWQALLELPFGATISYGELARRVGRPKAARAVAGAVGRNPISILIPCHRIIGHDTSLTGFGGGLPRKQALLAHEGHRYLSRAARARRVSTTQMELPFGAA
>LR134326.1|VEF39581.1|500219_501170_-|RlpA-like-protein-precursor
MIRSRPLALLSTLLLALAIAGCSTPGKKRGGYYKDDGPDANPPSNLDNVPDATPRLEPLASGPNRPYVVFGKRYVPDTSERPFRQQGLASWYGKKFHGNSTSNGESYDMYAMTAAHPTMPIPSYARVTSKINGRTVIVRVNDRGPFHSDRIMDLSYVAAHKLGIIGPGSGPVTVERILPAEILAMNGGAAAPRPGPASATGPLPVAAPSAAAAVELHPATQLASNAPTPPRPATGAGSGIYLQLGAFSQPANAESLVSRINGQLDPASGIPPAVVEQANNLYRVRIGPYATREAALGAVQPVADRTGILPSLSATP
>LR134326.1|VEF39582.1|501166_502039_-|glmZ(sRNA)-inactivating-NTPase
MLRVVLITGISGSGKSVALRLLEDAGFTCIDNLPVRFLAEFIANARDDAMERVAVAIDVRSPGELAELPDVITASRAMGTSLSVIFLDANTDTLVQRYSESRRRHPLTDRLARGGKTPSLAECIALERELMAPLRDQEHVIDTSDLTPGQLRAWIRDLIQADRPPLVLTFESFAYKRGVPSDADLMFDVRCLPNPYYDRTLRPLTGRDEPVATWLGGFDIVTQMIDDIAAFIRRWLPQYTQDTRNYLTVAIGCTGGQHRSVYVVEQLARRFSDHDPLLVRHRTQLPDDPA
>LR134326.1|VEF39583.1|502054_502963_+|Cytochrome-c4-precursor
MEFDRPCAPAGICYGLGCRICACPDGGQAGILAVGQAADVPAGRARVNFDSPMLAFKSDLRIAMRAWRAACGVLAAAAGMLAMSQAVAQGEAALRPDTMAARVAACTACHGEQGRAGPDGYYPRLAGKPQDYLYHQLLNFRDARRQYPPMAHLLNGLPDAYLREMAAYFAGQDVPYPPPARVEASAALVERGRLLVREGDPARAIPSCASCHGASLAGVAPAIPGLLGLPRDYLVAQIGSWQNGLRRAAEPDCMAQVSLKLTPEDIGAVSAWLAGQPVGHPYTPQPAGSLTLPLECGSQAGH
>LR134326.1|VEF39584.1|502973_504260_+|Alcohol-dehydrogenase-cytochrome-c-subunit-precursor
MKIIKRVLVVAILALLAAVATLYWLGTRDHVPAGPQAAPATGSADELVEQGRYLARAGNCMACHTARGGQAYAGGTPIPTPFGTLYGPNITPDAETGIGGWSADDFWQALHNGKGPGGRLLYPAFPYTEYTRMTRADADALYAFLRTVEPVRQASRPHELASPYDQRLLLAAWRALYFEPGGPQADPGQSLQWNRGRYLTEGLGHCAACHTPRNSLGATRAAEALGGGMIDGLGWYAPPLTGQPGTGLGDWSAQDIAALLTTGIAPHSTVAGPMAEVVLGSTQYLSGDDALAIGTYLKSLPAAAPPPARRGAPSATVMELGGKLYGQHCAQCHQADGKGSFPAWPALAGNPSVIAAEPANVIRMVLDGGFAPATAANPRPHGMPPFAQALPDNDIAMLVSYVRNSWGNQAGAVTPLDVKRTRESGAGR

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Crispr_ID: LR134326_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134326_2

774593-774686

Orphan

Consensus_repeat	Method
GTGCCTGTCCCGGCGGGGACAGGCAC	CRISPRCasFinder

1 spacers

The CRISPR arrays of LR134326_2

>merge|LR134326|2|774593-774686|CRISPRCasFinder
GTGCCTGTCCCGGCGGGGACAGGCACGCCCGCACAGCGGGCGCAGCGTGGGGGTTTTCCTGGGCCCGGGTGCCTGTCCCGGCGGGGACAGGCAC

>LR134326|2|2|774593-774686|CRISPRCasFinder
GTGCCTGTCCCGGCGGGGACAGGCAC	GCCCGCACAGCGGGCGCAGCGTGGGGGTTTTCCTGGGCCCGG
GTGCCTGTCCCGGCGGGGACAGGCAC

Protein	Signature genes	Signature genes Name	Protein_function
LR134326.1\|VEF39825.1\|768869_769325_+\|Predicted-membrane-protein	unknown	unknown	gnl\|CDD\|226610
LR134326.1\|VEF39836.1\|779841_780627_+\|Probable-enoyl-CoA-hydratase-echA8	unknown	unknown	gnl\|CDD\|181723
LR134326.1\|VEF39833.1\|777036_777555_-\|putative-Mg(2+)-transport-ATPase	unknown	unknown	gnl\|CDD\|224204
LR134326.1\|VEF39834.1\|777665_778421_+\|integral-membrane-protein,-YkoY-family	unknown	unknown	gnl\|CDD\|223930
LR134326.1\|VEF39835.1\|778616_779849_+\|Formyl-coenzyme-A-transferase	unknown	unknown	gnl\|CDD\|367110
LR134326.1\|VEF39830.1\|773602_773947_+\|Uncharacterized-protein-conserved-in-bacteria	unknown	unknown	gnl\|CDD\|225984
LR134326.1\|VEF39840.1\|783977_785006_+\|putative-acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|366103
LR134326.1\|VEF39832.1\|774916_777040_+\|Elongation-factor-G	unknown	unknown	gnl\|CDD\|234569
LR134326.1\|VEF39841.1\|785071_786265_+\|Acetyl-CoA-acetyltransferase	unknown	unknown	gnl\|CDD\|180775
LR134326.1\|VEF39823.1\|767541_767937_-\|GtrA-like-protein	unknown	unknown	gnl\|CDD\|377229
LR134326.1\|VEF39828.1\|770999_771974_-\|carboxylate/amino-acid/amine-transporter	unknown	unknown	gnl\|CDD\|223769
LR134326.1\|VEF39827.1\|770343_771003_-\|Cysteine/O-acetylserine-efflux-protein	unknown	unknown	gnl\|CDD\|224199
LR134326.1\|VEF39822.1\|765983_767582_+\|Undecaprenyl-phosphate-alpha-4-amino-4-deoxy-L-arabinose-arabinosyl-transferase	unknown	unknown	gnl\|CDD\|224720
LR134326.1\|VEF39831.1\|774035_774506_+\|Putative-universal-stress-protein-SAV1710	unknown	unknown	gnl\|CDD\|366180
LR134326.1\|VEF39829.1\|772057_773503_+\|2-aminoadipate-transaminase	unknown	unknown	gnl\|CDD\|224089
LR134326.1\|VEF39837.1\|780693_781665_+\|Argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|270234
LR134326.1\|VEF39838.1\|781675_782653_-\|Ben-and-cat-operon-transcriptional-regulator	unknown	unknown	gnl\|CDD\|176106
LR134326.1\|VEF39824.1\|767955_768873_+\|Uncharacterized-protein-conserved-in-bacteria	unknown	unknown	gnl\|CDD\|212118
LR134326.1\|VEF39826.1\|769330_770254_-\|acetoin-dehydrogenase-E2-subunit-dihydrolipoyllysine-residue-acetyltransferase	unknown	unknown	gnl\|CDD\|378820
LR134326.1\|VEF39839.1\|782778_783951_+\|Acyl-CoA-dehydrogenase-fadE12	unknown	unknown	gnl\|CDD\|173841

Protein	Function_ID	Function_description	E-value
LR134326.1\|VEF39825.1\|768869_769325_+\|Predicted-membrane-protein	gnl\|CDD\|226610	COG4125, COG4125, Predicted membrane protein [Function unknown].	2.35069e-54
LR134326.1\|VEF39836.1\|779841_780627_+\|Probable-enoyl-CoA-hydratase-echA8	gnl\|CDD\|181723	PRK09245, PRK09245, crotonase/enoyl-CoA hydratase family protein.	2.06175e-156
LR134326.1\|VEF39833.1\|777036_777555_-\|putative-Mg(2+)-transport-ATPase	gnl\|CDD\|224204	COG1285, SapB, Uncharacterized membrane protein [Function unknown].	1.52093e-44
LR134326.1\|VEF39834.1\|777665_778421_+\|integral-membrane-protein,-YkoY-family	gnl\|CDD\|223930	COG0861, TerC, Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism].	1.14565e-78
LR134326.1\|VEF39835.1\|778616_779849_+\|Formyl-coenzyme-A-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	8.36236e-118
LR134326.1\|VEF39830.1\|773602_773947_+\|Uncharacterized-protein-conserved-in-bacteria	gnl\|CDD\|225984	COG3453, COG3453, Uncharacterized protein conserved in bacteria [Function unknown].	7.81389e-35
LR134326.1\|VEF39840.1\|783977_785006_+\|putative-acyl-CoA-dehydrogenase	gnl\|CDD\|366103	pfam00441, Acyl-CoA_dh_1, Acyl-CoA dehydrogenase, C-terminal domain. C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.	1.19321e-12
LR134326.1\|VEF39832.1\|774916_777040_+\|Elongation-factor-G	gnl\|CDD\|234569	PRK00007, PRK00007, elongation factor G; Reviewed.	0
LR134326.1\|VEF39841.1\|785071_786265_+\|Acetyl-CoA-acetyltransferase	gnl\|CDD\|180775	PRK06954, PRK06954, acetyl-CoA C-acetyltransferase.	6.15168e-175
LR134326.1\|VEF39823.1\|767541_767937_-\|GtrA-like-protein	gnl\|CDD\|377229	pfam04138, GtrA, GtrA-like protein. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.	8.84202e-15
LR134326.1\|VEF39828.1\|770999_771974_-\|carboxylate/amino-acid/amine-transporter	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	1.6581e-12
LR134326.1\|VEF39827.1\|770343_771003_-\|Cysteine/O-acetylserine-efflux-protein	gnl\|CDD\|224199	COG1280, RhtB, Putative threonine efflux protein [Amino acid transport and metabolism].	4.25651e-32
LR134326.1\|VEF39822.1\|765983_767582_+\|Undecaprenyl-phosphate-alpha-4-amino-4-deoxy-L-arabinose-arabinosyl-transferase	gnl\|CDD\|224720	COG1807, ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane].	3.37964e-50
LR134326.1\|VEF39831.1\|774035_774506_+\|Putative-universal-stress-protein-SAV1710	gnl\|CDD\|366180	pfam00582, Usp, Universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.	9.38587e-30
LR134326.1\|VEF39829.1\|772057_773503_+\|2-aminoadipate-transaminase	gnl\|CDD\|224089	COG1167, ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism].	6.70342e-111
LR134326.1\|VEF39837.1\|780693_781665_+\|Argininosuccinate-lyase	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	9.41954e-117
LR134326.1\|VEF39838.1\|781675_782653_-\|Ben-and-cat-operon-transcriptional-regulator	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	2.33368e-60
LR134326.1\|VEF39824.1\|767955_768873_+\|Uncharacterized-protein-conserved-in-bacteria	gnl\|CDD\|212118	cd10807, YdjC_like_3, uncharacterized YdjC-like family proteins from bacteria. This subfamily contains many hypothetical proteins, and belongs to the YdjC-like family of uncharacterized proteins from bacteria. The YdjC-family is represented by an uncharacterised protein YdjC (also known as ChbG) encoded by the chb (N,N'-diacetylchitobiose, also called [GlcNAc]2) or cel operon in Escherichia coli, which encodes enzymes involved in growth on an N,N'-diacetylchitobiose carbon source. The molecular function of this subfamily is unclear.	1.57664e-91
LR134326.1\|VEF39826.1\|769330_770254_-\|acetoin-dehydrogenase-E2-subunit-dihydrolipoyllysine-residue-acetyltransferase	gnl\|CDD\|378820	pfam12146, Hydrolase_4, Serine aminopeptidase, S33. This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.	3.53768e-21
LR134326.1\|VEF39839.1\|782778_783951_+\|Acyl-CoA-dehydrogenase-fadE12	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	6.87275e-84

>LR134326.1|VEF39831.1|774035_774506_+|Putative-universal-stress-protein-SAV1710
MFKKILIPTDGSPLSAQAANAGICFARSTGAEVVALHVTQPFAATIGFDGMAAAYAITDEDYEKASAEQAEKYLKLILDRAETAGVKAESRAVSNFNVADGIVQAAGEAGCDLIFIGSHGRSGLSRLLLGSVTAKVLSLAHTAVLVYRVKEDKDKK
>LR134326.1|VEF39830.1|773602_773947_+|Uncharacterized-protein-conserved-in-bacteria
MSAAIKPLTENFAVAPQLGPTDMADVAAAGYKSVIINRPDFEGGPDQPTAADVSQAAQALGLQVEYQPVVGSAMTAADVARFAELLRTMPGPVLAYCRTGTRCTNLFAAAQQLG
>LR134326.1|VEF39829.1|772057_773503_+|2-aminoadipate-transaminase
MTVATSSPSGAGWQPVRQADATLVTQLADDLARRIDEHGLRPGTRLPSIRRMAEQSGVSRFTVVEAYDRLVARGLVQSRRGAGFFVRARSASLTALASARVPQAAPETPVRVDVSWLLRNMFRETAAGMPGGAGLLPPEWLDPDMVAAAVRAVGRTVRGNLVSYGSPQGYAPLRQQLASMLQADGVPAHPERNLLTTNGVTHGLDIVARHLIKPGDTVLVEDPAWFVIFGRLAAFGARPVGVPRGPDGPDLAMLDRLAAEHKPRLYIINGAVHNPTGHTLSAGAAYDILRLAERHDFMVVEDDTYADLHPGGAMKLAALDRLERVILVGGFSKMLAASLRVGYIAAGAETLQRLTDLKMLAGLTSPELGERVVHRVLVEGQYRRHIERVRARVNEARLRSIQALQQLGLSVPHEPHAGMFVWADCGRDSEPVARNAAERGMLLAPGTLFSPSGAPSTMLRFSVAMVDTPGIWQSIAAVMAQ
>LR134326.1|VEF39828.1|770999_771974_-|carboxylate/amino-acid/amine-transporter
MRRHGKPGRPLSPIQRQIFPMSPPSAQASAPSASPHAPSWEGYGYGLIGVLVFALTLPMTRLAVGELSPLLVGLGRALLAAVPAAALLWLTRSRRPDRAEWSGIVLAAVGIVVGWPVASTLAMASVPAAHGAVFNGLLPLSTAVFAAWRSGERPSPAFWSFAVLGAVLVAGYALRQGHGALQPGDLWLLLAVVLGGMGYAEGARASRTLGGWRTICWALVVSVPALLPAVLWLAHDAAWPSLPVAGAFAYLAFGSMFLGFFAWYRGLAIGGIARVGQIQLLQPFLTVVAAALLFNEQVEPITYVFAVAVVLVIAGGRRAMVRKA
>LR134326.1|VEF39827.1|770343_771003_-|Cysteine/O-acetylserine-efflux-protein
MIGSDLSSLDQAPLASLSVLMPLVLFTLVNSLTPGPNNVMLASSGLTFGFRRTIPHLLGISVGFSIMLLMVGLGLGATLERLPWLYSTLKYGGAAYLLYLAWKIATSGPMESGAERGKPLTFIQAALFQWVNPKAWVMIVSVVATYTPQHGYFANLIIATLVCGVVNLPSVGVWAAFGMALRRWLHRPAAVRAFNVGMAVLLVVSLYPVGLDLLALYTG
>LR134326.1|VEF39826.1|769330_770254_-|acetoin-dehydrogenase-E2-subunit-dihydrolipoyllysine-residue-acetyltransferase
MVSLPFRLSWRRMAAVLLLAAGALGFNQLDAWQRQAIFSPQTDQQRWWREPPAGTEVFDLALPNGDKVHAWYWQSPRRDAPTVLYLHGARWNLNGSAFRMEGWTRMGYSMLAIDYRGFGQSTPLLPSEQSASQDAAAALQELARRQPDPARRFIYGHSLGGAIAIDLAARPDLPPFAGLIVESSFTSIGAMLGTMKWGWVPGATLLVTQPFASVDKLAALTTPMLLLHGTADRVVPHTMSDELYRAAQQVPADLKRLVKIEGASHSGAIRSGRIYEDAVADFVRDAGRGYAGRQGAPPPLTASRPGT
>LR134326.1|VEF39825.1|768869_769325_+|Predicted-membrane-protein
MSSSSKQTPKTIKERFLHAFFFEIIAIGLSAPVAAWAMDQPLFDMGVLTAVIAWIALLWNMVYNAGFERLERRFGVVRTMPVRVAHAVGFELGLVLIIVPLAAWWLAISFWEAFMLDIGLLMFYLPYAFFYNLAYDKLRARWWGRIEPAGA
>LR134326.1|VEF39824.1|767955_768873_+|Uncharacterized-protein-conserved-in-bacteria
MRNQAGDVRCRRIAVCGDDFGMNEAIDGALIELAGAGRLSAVSCMPLAPAFAADAPALARLDVDLGVHVDFTEAFAGAAPAAPGLAALLWRAYAGQLDPDWIDARLASQFDAFERAFGRAPDYVDGHQHVHQLPGILPRLRALLKRRYAGQRIWLRHTAPGLQFGLPLAEAAKARLIGALGAGALARAAGQEGWQTNRRMLGVYGFTGGPRRYAGLLHHWLMNARDGDLLMCHPGWPQVHGAAHASQRAAEYEVLAHPELGTWLARNGLRIVRLSQVRGRQASQESGKVRNVPHSGSFRRLASRL
>LR134326.1|VEF39823.1|767541_767937_-|GtrA-like-protein
MRGLLRQIAWFIAVGCAAAATHWAVAVACVEWAGLPPLGANVVGWLLAFVVSFTGHFRLTFRHLAASWTIAARRFFLVSALGFAINELSYAWLLHATSLPYDVLLALVLIGLAFLTFVASRLWAFRHRHAP
>LR134326.1|VEF39822.1|765983_767582_+|Undecaprenyl-phosphate-alpha-4-amino-4-deoxy-L-arabinose-arabinosyl-transferase
MQPHAVSPGQARPWPLPAAGWLLLAVGVWLAFLSWMRPLALPDEGRYAGVAWDMLRNGSFAVPLIDGMPYFHKPPLYYWLAELSFRLFGVNEWAARLPSALAAWASAVALYLFVRRHRDAASATLCVLVLATLPLFFGGAQYANMDMLVAGMITLCVLAGADTALRVRGGQAWRAMALATGVCAALAMLAKGLIGLVLPGAILLAWLAWRRDWRGLRALLWPPAILAFAVVAVPWFWLMQVRYPGFFQYFFVHQHFERFAQTGFNNVQPFWFYLPVIAGLALPWSLWAGGLLRKQFWAADADPDGLRRLALVWLAVIVAFFSMPQSKLVGYIMPVLPPLAFLLAEVVMGALRDPAVARATRRMARVSALVAVAICVTAVFVASFNARGSSRELALSLRGELRPDDTLVALHTYPFDLQLYAHAARPMWVVDDWSNPEIPKRDNWRRELYDAVQFEPALGERLLVSADTFQQRLCQAPEGSRYWVWGTAADEEAYAPLRGQAARFADARRSLWLVLVDEAFKGRVCDGTPTGG
>LR134326.1|VEF39832.1|774916_777040_+|Elongation-factor-G
MTRRTSIERYRNIGISAHIDAGKTTTTERILFYTGITHKLGEVHEGAATMDWMEQEQERGITITSAATTAFWRGMAGNYPEHRINIIDTPGHVDFTIEVERSMRVLDGACMVYDSVGGVQPQSETVWRQANKYGVPRIAFVNKMDRVGADFFRVQRQIVERLKGDAVPIQIPVGAEDHFEGVVDLVKMKAIIWDDASQGVRFEYRDIPPELQAQAEQWREKMIEKAAEANEALLEKYLSGQPLSEDEIKSGLRARTVANEIVPMLCGSAFKNKGVQAMLDAVIDYLPSPADVPAIIGHDERDREIERHPADDEPFSALAFKIMTDPFVGQLVFFRVYSGVVKSGDSVLNPLKSKKERLGRILQMHANERREISEVYAGDIAAAVGIKEITTGDTLTDPAHVIILERMTFPEPVISQAVEPRTKADQEKMGIALNRLAQEDPSFRVRTDEESGQTIISGMGELHLEILVDRMKREFGVEANVGKPQVAYRETIRSTVTDVEGKFVKQSGGRGQYGHVVLKLEPQEQGKGYEFVDAIKGGVVPREFIPAVDRGVRETLNTGVLAGYPVVDVKVTLVFGSYHDVDSNENAFRMAASMAFKEGMRRAKPVLLEPMMHVEVETPEDFTGNVMGDLSSRRGMVQGMEDIAGGGGKLVRAEVPLAEMFGYSTSLRSLTQGRATYSMEFKHYAEAPRQVAEQIIAARGSGAAARG
>LR134326.1|VEF39833.1|777036_777555_-|putative-Mg(2+)-transport-ATPase
MDTVWMEIWTTVRNEFADIPDVAEATRIVLRLGMAVALGGLLGYERERSGKAAGLRTHMLVALGAALFVLVPLQGGMEVGDLSRVLQGVIAGIGFLGAGAIIKLGNEGEIRGLTTSAGIWLTAAIGVAAGMGREATALASTLIALFVLAALRRLEKRIAARDDKRVVAQPPP
>LR134326.1|VEF39834.1|777665_778421_+|integral-membrane-protein,-YkoY-family
MDYLVSLAQQPAAWAALATLIAMEVVLGIDNLIFISILTNKLPPQHQTKARRIGIGMALILRLALLGTVAFIVQLTQPVFELFGHGFSWRDVILVAGGLFLVWKATKEIHHHVDPNPGDDMFGGKAATLGFAAAVAQILMLDLVFSIDSIITAVGMTEHIPIMFVAVIVAVAVMLLAAEPLARFIERNPTVVMLALAFLMMIGMTLIAEGFGAHVPKGYIYAAMAFSALVEGLNMMARRAREGRGAGAAGG
>LR134326.1|VEF39835.1|778616_779849_+|Formyl-coenzyme-A-transferase
MSGPLEGVRILDVTTVLMGPYATQILGDLGADVIKVEPPAGDNVRGIGPGRHADMGGIFLHANRSKRSIALDLKNPAGREALLKVAATCDVLVYNVRPQAMARLGLSYAEVAQANPSILYVGMYGYDQRGPYAARAAYDDLIQGAVGIPSLSVEAGSDIPRYAPSAMVDRIVGISAANAVTAGLYHRARTGQGQAIDVPMFETMAHLILGDHMMGQTFEPPLGPPGYPRILNADRRPYATRNGHICVLLYADKHWKAFFELIGQPGRDAADPRFRDIGTRTQHIHAIYRLVSDAIASRTTEEWLAAFEAADIPAMPVHTMASLLRDPHLEAIGFFGMVDHPSEGAVRMMAVPSRWSGTPPQPRGHAPRLGEHSVDVLKEAGYDDEAIAALVRNGAAIAAARQLPEGTDHD
>LR134326.1|VEF39836.1|779841_780627_+|Probable-enoyl-CoA-hydratase-echA8
MTDFLRHERHGGVLLLTMDRERTRNALSDADAVEALVQACARIGADLSVRAVVLTGSHGVFSSGGNLKTLSDTVGAGLGEPVHSRQAYRSGIQRIPLALYNLEVPTIAAVNGPAIGAGCDLACMCDIRLAARQASFAESFVKLGLTPGDGGAWLLPRIVGMSRACELAFTGRSIDAARARELGLVSEVFDADALLPAALALAQEIAQHSGHALRLTKRLLREGQHTRLDTLLELSAGFQALAHHTQEHAGALDAHLSRKRG
>LR134326.1|VEF39837.1|780693_781665_+|Argininosuccinate-lyase
MHSRTLALALLSVAALAQGGSARAASDYPAHPVKIIVSLPPGSGADTTARFLSKHLAERFKQPFVVENRPGGNSFIAAQAVATAPPDGYTLFVASNSPMTTNAAVFKNLPYDAVKDFAPVAPIARFPMALVVPANSPYRSVADLVAAARAAPGQLNFASGTATYQVVLELFHEQNGIKATHVPYKGTSAALADVAGGVVQYSVADVSAALPLIRGGKLRPLAVTSTRRIKDLPDVPTMQESGNKGFEAYAWTAAFFPAKVDPAIVARVSDAVQALVRSQEGKAFMEQLGGEPFVGGPNTLAAFQRDELASMRRIAKLANIQQE
>LR134326.1|VEF39838.1|781675_782653_-|Ben-and-cat-operon-transcriptional-regulator
MWTGQYIVHIASPAHHWRRAVELRQLKQLLVLSETLNFHRAAERLHMAQPPLSTAIKKLEQELGVQLFERLPAGLQPTPAAEVVLRYARATLFYADEIQRAAQEGASGKQGMLKVGFVGSSIYSLMPQLLSAFRKDYPRVDLVIEESTTVDLLRRLDAHTLDVALVRFPVLEPSTARITLLQADHLMLAVPAGSRYAQRDDVALDELADEPFIGYSRTHVPGMHALIMYAFQQYGVVPHIAQEAIQVQTILSLVESGLGLAIVPKVACRQAGSGVRLVNVPQLAETIKVGIALAVHPDNATPTTANFVDMACRLMQTEPAAGQAR
>LR134326.1|VEF39839.1|782778_783951_+|Acyl-CoA-dehydrogenase-fadE12
MGAILGTIIEALQLAAIPAHDEALRPAVRAFLDEALREMPADRRARSWMGHDAEFSRALARQGWLGLTLPVEYGGAGRSNFARFVLSEELLAAGAPVSAHWIADRQTAPLILRFGSPAQRAFYLPRIIRGEAFFAIGMSEPDTGSDLASVRTRATPVADGWLLNGRKIWTTNAHRSHYMCALVRTSGAPEDRHRGLSQMIFDLALPGIEIRPIRDIAGDAHFCEVLFDNVLLPHDALVGEEGSGWRQVMAELALERSGPERIYSSMVLLDGWLAHLRRDAAPQRAQVCLAGRLAARLAVLRSMSLAVSQRLEQGADASLAAVLVKDLGTEFEQAVPELIGQALHASPQPAPDDVLMRTLAYLTLINPTFSLRGGTRHILRGIIARELGLR
>LR134326.1|VEF39840.1|783977_785006_+|putative-acyl-CoA-dehydrogenase
MVSTMQQDLYETFARALAGLCPLERVRELEAAADPRAGAARAWNEVDALGYGDALSPAEHGGAGLSLADAEGLLRAAGAMALPFPFADTLLARALLRAAGQAVPDGPIALGVALPHGAGWRCAPIAGVALAQAVAVEHDGCLALWPAPDAVQPGLFRPRASGAPAWRGTPAQAGRAGAPAGAVQAWRNAADAAGMAGAMQAVLDRCVAYVQERQQFGRALGRFQAVQQDISMLAEQVAAVAMAARLACASGALFPDPALAACARLRACEAVPVVCALAHAVHGAIGITEELPLGLYTARLHEWRATGMSEDDCAELLGRRVLADGERTLLDVVRGMVSAAHA
>LR134326.1|VEF39841.1|785071_786265_+|Acetyl-CoA-acetyltransferase
MSVHPDPVVIVAARRTPIGAFQGALAHYSAPQLGAHALAAAVRQAGLQPDAAQEALMGCCLFAGLGQAPARQAVLGAGLPTDVQATTLSKMCGSGMKAAMLAHDMLRAGSADVVLAGGMESMSNAPHLIPKARQGYRLGDGQLLDHMYRDGLQDAYEGRLMGHYADLAAREYGFSREQQDAYAHESVLRAQRSVAEGEFAEEIAPIAGLARRGAPAAMVAVDETPGLCDVSRLASLKPVFNADGTVTAGNASSISDGAAALVLTRQAHAERLGLAPQARIVGHATAALPPGQFPAAPVRAIARLFERVGWDRDSVDLFEINEAFAVVTMIALRELGLPAERVNVNGGACALGHPVGATGARLIVTLMHALRRRGLRRGVACLCLGGGEATAIAVERA

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Crispr_ID: LR134326_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134326_4

3039607-3039704

Orphan

Consensus_repeat	Method
GTGCCTGTCCCGGCGGGGACAGGCACCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of LR134326_4

>merge|LR134326|4|3039607-3039704|CRISPRCasFinder
GTGCCTGTCCCGGCGGGGACAGGCACCCAGCCGCAGATGTCAGTCCCCATGCCGCTGGCGCATGACGGCGTGCCTGTCCCCGGCGGGGACAGGCACCC

>LR134326|4|4|3039607-3039704|CRISPRCasFinder
GTGCCTGTCCCGGCGGGGACAGGCACCC	AGCCGCAGATGTCAGTCCCCATGCCGCTGGCGCATGACGGCG
TGCCTGTCCCCGGCGGGGACAGGCACCC

Protein	Signature genes	Signature genes Name	Protein_function
LR134326.1\|VEF43134.1\|3048326_3049349_-\|2-keto-3-deoxygluconate-permease	unknown	unknown	gnl\|CDD\|235384
LR134326.1\|VEF43136.1\|3049598_3050525_-\|ectoine-hydroxylase	unknown	unknown	gnl\|CDD\|131461
LR134326.1\|VEF43116.1\|3037109_3038486_-\|Protein-of-uncharacterised-function-(DUF1446)	unknown	unknown	gnl\|CDD\|377804
LR134326.1\|VEF43118.1\|3038582_3039533_+\|HTH-type-transcriptional-regulator-gltC	unknown	unknown	gnl\|CDD\|176131
LR134326.1\|VEF43106.1\|3031663_3033298_-\|Glutathione-import-ATP-binding-protein-GsiA	unknown	unknown	gnl\|CDD\|224048
LR134326.1\|VEF43120.1\|3039803_3041141_-\|glycerol-3-phosphate-transporter-periplasmic-binding-protein	unknown	unknown	gnl\|CDD\|182876
LR134326.1\|VEF43110.1\|3034138_3035083_-\|Glutathione-transport-system-permease-protein-gsiC	unknown	unknown	gnl\|CDD\|223674
LR134326.1\|VEF43102.1\|3029372_3030134_-\|Pertussis-toxin-liberation-protein-F	unknown	unknown	gnl\|CDD\|132874
LR134326.1\|VEF43100.1\|3027798_3029376_-\|type-IVB-pilus-formation-outer-membrane-protein,-R64-PilN-family	unknown	unknown	gnl\|CDD\|274177
LR134326.1\|VEF43130.1\|3046056_3047112_-\|4-hydroxythreonine-4-phosphate-dehydrogenase-2	unknown	unknown	gnl\|CDD\|273137
LR134326.1\|VEF43127.1\|3044200_3045073_-\|Uncharacterized-Fe-S-protein	unknown	unknown	gnl\|CDD\|225758
LR134326.1\|VEF43114.1\|3036757_3037117_-\|Uncharacterised-protein	unknown	unknown	unknown
LR134326.1\|VEF43108.1\|3033290_3034121_-\|Glutathione-transport-system-permease-protein-gsiD	unknown	unknown	gnl\|CDD\|224094
LR134326.1\|VEF43132.1\|3047108_3048326_-\|Uncharacterized-protein-conserved-in-bacteria	unknown	unknown	gnl\|CDD\|377757
LR134326.1\|VEF43112.1\|3035135_3036710_-\|Glutathione-binding-protein-gsiB-precursor	unknown	unknown	gnl\|CDD\|173867
LR134326.1\|VEF43124.1\|3042597_3043644_-\|CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3--dehydrase-reductase	unknown	unknown	gnl\|CDD\|181058
LR134326.1\|VEF43104.1\|3030311_3031667_-\|Glutamyl-tRNA(Gln)-amidotransferase-subunit-A	unknown	unknown	gnl\|CDD\|223232
LR134326.1\|VEF43129.1\|3045149_3046052_-\|Uncharacterized-HTH-type-transcriptional-regulator-yegW	unknown	unknown	gnl\|CDD\|225099
LR134326.1\|VEF43122.1\|3041145_3042402_-\|Sarcosine-oxidase-subunit-beta	unknown	unknown	gnl\|CDD\|234819
LR134326.1\|VEF43126.1\|3043701_3044070_-\|Aspartate-1-decarboxylase-precursor	unknown	unknown	gnl\|CDD\|180090

Protein	Function_ID	Function_description	E-value
LR134326.1\|VEF43134.1\|3048326_3049349_-\|2-keto-3-deoxygluconate-permease	gnl\|CDD\|235384	PRK05274, PRK05274, 2-keto-3-deoxygluconate permease; Provisional.	9.56796e-132
LR134326.1\|VEF43136.1\|3049598_3050525_-\|ectoine-hydroxylase	gnl\|CDD\|131461	TIGR02408, putative_L-proline_4-hydroxylase, ectoine hydroxylase. Both ectoine and hydroxyectoine are compatible solvents that serve as protectants against osmotic and thermal stresses. A number of genomes synthesize ectoine. This enzyme allows conversion of ectoine to hydroxyectoine, which may be more effective for some purposes, and is found in a subset of ectoine-producing organisms.	0
LR134326.1\|VEF43116.1\|3037109_3038486_-\|Protein-of-uncharacterised-function-(DUF1446)	gnl\|CDD\|377804	pfam07287, AtuA, Acyclic terpene utilisation family protein AtuA. This family consists of several bacterial and plant proteins of around 400 residues in length. One member of this family has been characterized in Pseudomonas citronellolis as AtuA, a member of a gene cluster that is essential for the acyclic terpene utilisation (Atu) pathway.	2.30072e-160
LR134326.1\|VEF43118.1\|3038582_3039533_+\|HTH-type-transcriptional-regulator-gltC	gnl\|CDD\|176131	cd08440, PBP2_LTTR_like_4, TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold. LysR-transcriptional regulators comprise the largest family of prokaryotic transcription factor. Homologs of some of LTTRs with similar domain organizations are also found in the archaea and eukaryotic organisms. The LTTRs are composed of two functional domains joined by a linker helix involved in oligomerization: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal substrate-binding domain, which is structurally homologous to the type 2 periplasmic binding proteins. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcriptional repressor undergoes a conformational change upon substrate binding which in turn changes the DNA binding affinity of the repressor. The genes controlled by the LTTRs have diverse functional roles including amino acid biosynthesis, CO2 fixation, antibiotic resistance, degradation of aromatic compounds, nodule formation of nitrogen-fixing bacteria, and synthesis of virulence factors, to a name a few. This substrate-binding domain shows significant homology to the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	1.58441e-67
LR134326.1\|VEF43106.1\|3031663_3033298_-\|Glutathione-import-ATP-binding-protein-GsiA	gnl\|CDD\|224048	COG1123, COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only].	0
LR134326.1\|VEF43120.1\|3039803_3041141_-\|glycerol-3-phosphate-transporter-periplasmic-binding-protein	gnl\|CDD\|182876	PRK10974, PRK10974, sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB.	1.31172e-74
LR134326.1\|VEF43110.1\|3034138_3035083_-\|Glutathione-transport-system-permease-protein-gsiC	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.42336e-123
LR134326.1\|VEF43102.1\|3029372_3030134_-\|Pertussis-toxin-liberation-protein-F	gnl\|CDD\|132874	cd06911, VirB9_CagX_TrbG, VirB9/CagX/TrbG, a component of the type IV secretion system. VirB9 is a component of the type IV secretion system, which is employed by pathogenic bacteria to export virulence proteins directly from the bacterial cytoplasm into the host cell. Unlike the more common type III secretion system, type IV systems evolved from the conjugative apparatus, which is used to transfer DNA between cells. VirB9 was initially identified as an essential virulence gene on the Agrobacterium tumefaciens Ti plasmid. In the pilin-like conjugative structure, VirB9 appears to form a stabilizing complex in the outer membrane, by interacting with the lipoprotein VirB7. The heterodimer has been shown to stabilize other components of the type IV system. This alignment model spans the C-terminal domain of VirB9. CagX is a component of the Helicobacter pylori cag PAI-encoded type IV secretion system. Some other members of this family are involved in conjugal transfer to T-DNA of plant cells.	7.06997e-30
LR134326.1\|VEF43100.1\|3027798_3029376_-\|type-IVB-pilus-formation-outer-membrane-protein,-R64-PilN-family	gnl\|CDD\|274177	TIGR02520, putative_Type_IV_pilus_protein, type IVB pilus formation outer membrane protein, R64 PilN family. Several related protein families encode outer membrane pore proteins for type II secretion, type III secretion, and type IV pilus formation. This protein family appears to encode a secretin for pilus formation, although it is quite different from PilQ. Members include the PilN lipoprotein of the plasmid R64 thin pilus, a type IV pilus. Scoring between the trusted and noise cutoffs are examples of bundle-forming pilus B (bfpB). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking].	7.34755e-54
LR134326.1\|VEF43127.1\|3044200_3045073_-\|Uncharacterized-Fe-S-protein	gnl\|CDD\|225758	COG3217, COG3217, Uncharacterized Fe-S protein [General function prediction only].	6.93466e-61
LR134326.1\|VEF43130.1\|3046056_3047112_-\|4-hydroxythreonine-4-phosphate-dehydrogenase-2	gnl\|CDD\|273137	TIGR00557, pdxA, 4-hydroxythreonine-4-phosphate dehydrogenase. This model represents PdxA, an NAD+-dependent 4-hydroxythreonine 4-phosphate dehydrogenase (EC 1.1.1.262) active in pyridoxal phosphate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine].	4.07591e-117
LR134326.1\|VEF43108.1\|3033290_3034121_-\|Glutathione-transport-system-permease-protein-gsiD	gnl\|CDD\|224094	COG1173, DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	1.14667e-85
LR134326.1\|VEF43132.1\|3047108_3048326_-\|Uncharacterized-protein-conserved-in-bacteria	gnl\|CDD\|377757	pfam07005, DUF1537, Putative sugar-binding N-terminal domain. This conserved region is found in proteins of unknown function in a range of Proteobacteria as well as the Gram-positive Oceanobacillus iheyensis. Structural analysis of the whole protein indicates the N- and C-termini interacting to produce an interacting surface into which a threonate-ADPcomplex is bound, suggesting that a sugar binding site is on the N-terminal domain here, and a nucleotide binding site is in the C-terminal domain (manuscript in preparation). There is a critical motif, DDXTG, at approximately residues 22-25.	1.29197e-54
LR134326.1\|VEF43112.1\|3035135_3036710_-\|Glutathione-binding-protein-gsiB-precursor	gnl\|CDD\|173867	cd08502, PBP2_NikA_DppA_OppA_like_16, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
LR134326.1\|VEF43124.1\|3042597_3043644_-\|CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3--dehydrase-reductase	gnl\|CDD\|181058	PRK07609, PRK07609, CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated.	0
LR134326.1\|VEF43104.1\|3030311_3031667_-\|Glutamyl-tRNA(Gln)-amidotransferase-subunit-A	gnl\|CDD\|223232	COG0154, GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis].	6.98538e-115
LR134326.1\|VEF43129.1\|3045149_3046052_-\|Uncharacterized-HTH-type-transcriptional-regulator-yegW	gnl\|CDD\|225099	COG2188, PhnF, Transcriptional regulators [Transcription].	2.15288e-54
LR134326.1\|VEF43122.1\|3041145_3042402_-\|Sarcosine-oxidase-subunit-beta	gnl\|CDD\|234819	PRK00711, PRK00711, D-amino acid dehydrogenase.	0
LR134326.1\|VEF43126.1\|3043701_3044070_-\|Aspartate-1-decarboxylase-precursor	gnl\|CDD\|180090	PRK05449, PRK05449, aspartate alpha-decarboxylase; Provisional.	1.84176e-73

>LR134326.1|VEF43118.1|3038582_3039533_+|HTH-type-transcriptional-regulator-gltC
MRPQADLSTRQLRAFVMLADLRHFTKAAQACHLSQPAFSALIQSLEATLAMQLFDRSTRRVVLTQEGELFEPLARRLLADLGHAMTHIASFVELRRGRVHVAALPSLAAGWLPKVLHEFHAEHPDIELMLSDVLSDECIELVRSGQADFALASRGIRASDPAVLHARELCSDTFHLICRKDHPLAREPRLTLKHLAPWPFIHLTRNSSVRQTVEAALRPQVAKTILEVAQLATVAGMIEAGLGISVVPTFTLYQFERPGLLIRPISLPGLTRQIYIVRRQEERLSIAAQALYDLVVAKLGTPAAAKPRRRRTEKGR
>LR134326.1|VEF43116.1|3037109_3038486_-|Protein-of-uncharacterised-function-(DUF1446)
MRSLPSLLIGCAAGFSGDRVDAAGPVVDTLIARLGGVPANGRAFLIFETLAERTLALAQLRKRADAQAGYEPLLEDMLGPVLARCLAHGIRIVSNFGAANPEGAARHILRMAARLGLRKPRIAVVKGDDVSGAQHAGMLAEYLGEQYDPSSIVSANAYLGSEQIRDALDHGAEIVVCGRVADPSLTVGPAMSYFGWQADDWDRIGRATMAGHLLECGAQVCGGYYADPGYKDVPGLEQVGFPVAEIDEDGHCIIGKSDGTGGLVDEATVIEQLLYEVHDPAGYLTPDVVADISQAEVRRVADNQVRLTGVRGHPRPAAYKVNVCLEGGWLAEGEISYAGPRAEARARLAAEVVCKRLADLRIRTDLIGRVSIFGDDAGRLLAGAPAGDGEDVRLRLAAHAVTRQDAMRLTREVTALYCCGPAGGGGVRTTLTPRLDMVSCLLPRDLVRAGFEMVDADV
>LR134326.1|VEF43114.1|3036757_3037117_-|Uncharacterised-protein
MSDVLVPLFRVAHARTGDKGDRSNISVIAWDRALYPLLVEQLTPEVVLAQFAHRRPAGAQRYLLPKLGAMNFVLDAVLDGGVNGALNLDAHGKALSYLILKTEIAVPSDLVCRLAGSPG
>LR134326.1|VEF43112.1|3035135_3036710_-|Glutathione-binding-protein-gsiB-precursor
MRYLKSTYAAVLLAIGTAVPHATTLAQEVKVAAEAPLRLLDPVGTTAYITRNHAYMVYDTLFALDAQLKPQPQMVSTWSVSPDKLVYRFTLRDGLKFHDGSPVTAADCVASIKRWAQRDLTGLRMMAAAKEITAKDDKTFEIVLEQPFGAVIEGLSKASSLPAFIMPKRIADAPASQAITEVIGSGPFRFVASEYRPGLQVVYERNTDYVPRSEPPSGLAGGKVVNVDRVVWLSLPDIQTEANALAKGEVDYVQTVYPDVVQTLQASKDVVIQKLASTTTPTLRLNWLQPPFNNQKVRQALLHAVSQRDYMDAQVGDPKAYRVCWAMFGCDSPLASTAGVVSQDDEADLNAAKALLKESGYKNEKAVVLHATDYPPTSAIAPFTAQILRSIGMKAEVQSMDWATFLTRRGKQDPVEKGGWSVAYGSWNTLDLMSPIANLNLDGRGKEGYAGWTESAEMESLRTQYAQATEPASRQQIAAKIQQLAYDQVFYIPLGTYSNYAARRSNVTPLLDAPVTVFWGISKN
>LR134326.1|VEF43110.1|3034138_3035083_-|Glutathione-transport-system-permease-protein-gsiC
MQILRLLFLRLASAIPVVLVVVTVVFLLVRLTGDPATILAGDMASPEVVASVRADLGLDRPLLGQYAQWLWDLLQGNLGTSIVTKQPVATLIGERLESTLVLSLSALVVTVLLAVPLGVLAAWRHNTLVDRVVMIYAVIGFSLPSFVVGYLLILMFSVWLGWLPVQGYVSITDDIWLAAQHLVLPTLALAIFYMSLISRVTRASVLEVLNEDFVRTAKAKGVPPLRILSQHVLRNAAIPIVTVIGIGLAFLISGVVITESVFNLPGLGRLTIDAVLSRDYPVVQGVILFFACVYILVNLLIDMLYVVIDPRIRY
>LR134326.1|VEF43108.1|3033290_3034121_-|Glutathione-transport-system-permease-protein-gsiD
MTSILRHNRLALLGGGVLLLMVAISVAASWIASMDPAMMQPRMRLTPPGEAFLLGTDALGRDVYSRVVHGSRMSLAIGALVVVITIAIGTLIGLVAGASRIMDRVLMRIMDGVMAIPGILLAVALVSLFGASLASVVIAIAVPEIPRVVRLVRSVVLSVREEPYVEAAVGLGVPYPKVVWRHILPNCFAPLIVQASYVFAAAILLEAVLGFLGVGFPPEIPTFGNILAEARPVFQRAPWATVAPGLLLAVTVLAVNLLGDGLRDSLDPKLARRAND
>LR134326.1|VEF43106.1|3031663_3033298_-|Glutathione-import-ATP-binding-protein-GsiA
MIENTPKQRVLEVSGLAIRAGARTLVQDVTLSLAQGEILCLVGESGSGKSLTASAVMGLLPGNLGVSAGSIRLDGEDLTAASPARMQALRGDRMAMVFQEPMTSLNPLMRVGRQIAEVLQVHRPDLGAGQVRARVLELMGDVHLPTPEALMDAFPHQLSGGQRQRIMIAMALALEPALIIADEPTTALDVTTQAQVLKLFRQLLAKHSSAVLFITHDFDVVRDIADHVAVMQLGRIVEQGPAGQVLDAPRHDYTRKLLAAVPSGVPKTQQNASSDELLSVSGLNLVYESRGLLGPARRTHAVADVGFTLKKGETLGVVGESGSGKSTLGRCITRAHAPTSGRIVFDGVDIAGLSGKALRAVRRRVQMVFQDPYRSLNPRRRILHALIEGPIESGVDRKAACARAAELMALVGLPADGLQRYPHQFSGGQRQRICIARALAMEPDLIVADEAVSALDVSVQAQVLELFEDLQKRLGFAMIFITHDLRVAAQVCDRIGVMQKGRLLELGPVRQVIHAPQHPYTRHLFDSLPGRVGQAAEPAMELQA
>LR134326.1|VEF43104.1|3030311_3031667_-|Glutamyl-tRNA(Gln)-amidotransferase-subunit-A
MTSTDQHIARAGVAELARGIARGAFTPAEVTDVFLRRIQDLNPAIGAFVAVYEDEARHAARQATQALAQGQRLSPLHGIPFAVKDIVDVAGRFTTYGSRTGAGRQAGATAEYVRALLDAGMILLGKTHTVEFAFGGWGTNQRMGTPRNPLRADVPCATGGSSSGSGAAVGAQMVPFAVGTDTGGSIRIPSAFCGLTGMRPSMGRHSGAGVMSLSHTLDTIGPLARTVEDVQMLDDLLTGKTATDTAQPGSQAVARVRDARIGVLGAQWLGAIEPEVAHAYAQSLRAFEAMGATLVELALPFDREAFAQLTSTLIACEGLQFAGKYVHDPLSGMDEDVRARFLVGDRYDAAAYAELLGRRSAMIDTFTQAMAGVKALLMPTTPCVAQPLAGLEQSPYNPAVYTRMPAWLGCCALAVPNGSGAHGLPTSLQIVGLPESDRLVMSLGRAYQEYA
>LR134326.1|VEF43102.1|3029372_3030134_-|Pertussis-toxin-liberation-protein-F
MVRSLSIVCLLAVLQACAGPRPAAVAAAWDEAPAGQYRFDWQLSGDPAVAPLQVFDDARRIWLQFAPGQPIPAIFAHGAGGERPVPYLRRDPYIVVDGAWPALSLRGGRYVARIQRSGAPIPAGAPVVRAEGPAPVPATPSAVAPAEAAEAAPPAPRFRAAPPDLTLRAVLARWARAAGWTFEAEHWALDVDIPLAGKAELPGDFKTAVRALLAATELSERPAQPCFYANRVLRVVPLAQACDRTRAAAPGLT
>LR134326.1|VEF43100.1|3027798_3029376_-|type-IVB-pilus-formation-outer-membrane-protein,-R64-PilN-family
MKARRLAMAGLSLALGGCSLSQQMQAMRDAATSLRARLLEGQQAVGRAGERPAREAAQDVARPWLAGRAQPLAREVLLPPALRADVDTTLLFAGKATLPVLAERLHRATGIAVRVHPDALLPRAAFLPRLAGPAELAAEPPAQAELRAGPRPLADTLDALAAQLYVHWRYHRGAIEFYRTETRVFDVRTLALAASAQARLGRAGSGETGSFDHASSTVLSADAGKALQAVRDRVAAFLTRAGVIAEIEAGGSTLAVTDTPEALARIEKYLQGENRALTRRVRLVFEELTVRTMAAAEGGIDWQAVYASARAAASYAMPGGAGAAGALGARVLAGPWRDARALIAALSTMGAVLRHRSIPMLTLNRRAVTHAVRTTFSYVDQVQRLSPTAAAPGGRDAVPGLAVQQKRETVGTFLTLLPEARDDGRILLSISYDNTIAQPLRTLTFGEGGQQVSLQQIAIDGSGIVQQVELLPGQPVILSGFDHSEDQYERHRLFPDAPLAAGGHDRTARERVTTVVMVTAQIDEG
>LR134326.1|VEF43120.1|3039803_3041141_-|glycerol-3-phosphate-transporter-periplasmic-binding-protein
MKKLQMTGFARAMRASRRACVLGLAMAAMGVAQAADSVEIQVWHTLSGPNKAEFEKLAKQFNKEQGDVVVKLRDFGNQDDLKKEAVSAVKSKKGPNLVQLADNHSPEVVAEHKSILPLHQLLAKYPVKDLNWFLPSTTSFTRDGKGRLLAFPWMAEVPVMFYNTAYYKKAGLDPNKPARTWADLQAELLKLRDVANIDCPYATSDQVTVHLENLAPVNNQLYATLNNGLDVAKKGSPSMQFDTLYMRHVSLMVSWKRSLLLTAYSDDNKSDQLFAKGECAVLTTSSSALGQFLNTRSLSFGVAPLPYYDQVTKTGGRPFVSGSALWAMEGHPQAEEKATAKFLAWLSKPVIAAEWHQRTGYLPLTEAAFRASDVSFYNKVPGAQQLVELMRNPPAATSRGFRIANYERIEPVLNTQLTAAFDGKTPPVAALNNAASQARSLAAQR
>LR134326.1|VEF43122.1|3041145_3042402_-|Sarcosine-oxidase-subunit-beta
MKVAVLGSGIIGVSSAWWLSQAGHDVVVVDRCTGAAQETSLANGAQISVSYAEPWANPQAPFKLLKWMFQDDAPLLFRPQLDWRQWQWGLAFLRECLPSRLAPNIRAMVRMAEYSRATLQGMRAELGIQYDHLERGILNFYRDQREFETSQRAAGLMRDFGVERRVINADEVVAIEPALAPHRQTIVGGDYTPEDESGDVHLFAAALARRCEAAGVEFRFSTRVTRLLGEGGRVQGVELIEPDGRYGRLDADAFVVAMGSFSAQLVRPLGVPCMVYPAKGYSATFPVRPGALAPVVSLTDSSHKVVFSRLGERLRMAGTAELSGYSRGLNTGRCEAMTRLARELFPDALDFERVSYWSGLRPSTPSNVPLIGRTSVSNLYLNTGHGTLGWTMGVGSGRALADLLSGRRPEPEFPFLGL
>LR134326.1|VEF43124.1|3042597_3043644_-|CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3--dehydrase-reductase
MSFQVTIEPSKHQFQAEAGQTVLDAALAAGIVLPYSCRTGACSTCKGKVVAGEVDAGPYPAQILSPEDLAQGYTLFCQAKPQSDLVVESTEVRLASDIQIRKLPSRVQTIERVAPDVAVLKLQLPASEQFRYYAGQYIEVILKDGKRRSYSMAGAPHTGSPLELHIRHMPGGLFTDHVFGAGDTQMKEREILRLEGPFGSFFLREDSDKPIVLLASGTGFAPVKAIVEHMIHNQIQRPAVLYWGGRRPRDLYHDALAQSWAGSLPGFRYVPVVSDALDEDGWSGRTGYVHEAVMQDLSDLSGYEVYACGTPLMVDAARREFSAQCGLPAEAFYADAFTSEADLAKATP
>LR134326.1|VEF43126.1|3043701_3044070_-|Aspartate-1-decarboxylase-precursor
MQRIMLRAKLHRVTVTEADLHYEGSCGIDEDLLDAAGMREFERIELYNVTNGERFDTYIIKAARGSGAISLNGAAARRAQVGDLLIICTYGPMSEEQSATHKPQVVLVDDANRVKEIRKFPA
>LR134326.1|VEF43127.1|3044200_3045073_-|Uncharacterized-Fe-S-protein
MSTRIRSLHIYPVKSCAGIDLAESIVDRAGLAHDRRWMVTTAAGQFMTQRQYPQMARIRTALEDGMLVLRAPGMEDLRIPADGSELAERTQPVGVWRDTVIARAEHPRSAEWLSRFLGLPCRLLKIDLRADRSANPEWVDTWLERHPEWAEDFAGDHFFGFADGFPLLVANQSSLDELNERLAARGQAPVPMNRFRANIVVEGDWPAFEEDQTACIVAGGVRMAFVKPCTRCPMPNVDQVTAEVYDEPGLTLTTFRSLEIGVVFGQNAIVDRTAPAPLRVGDAVEIELDF
>LR134326.1|VEF43129.1|3045149_3046052_-|Uncharacterized-HTH-type-transcriptional-regulator-yegW
MALSAIEPFALDRSGATPLHAQVADAIRNHIRDHRLTAGTVLPSEAALCHSFGVARSVVRQALGALVAEGLIRRDPGRAPVVAPPREHRRMVQRSAGLYEQFAGLGVALRTRVLACRPAEPPPEVAAFFGTTETLLLERLRSVDAQPLAYVRTWLPRAAIAGLAADHLQDASLHRVLAQRFGLRPGRGRNRIRAVAAEAALAQALDVAPGSPLLMLEGQGLDQDGHPLEWFTTWHRPENLVFDVDVGQERESVQPALTCGTAAVAPPAVAAPPSGALDAVEQSLLQALQAVRRARGDQQE
>LR134326.1|VEF43130.1|3046056_3047112_-|4-hydroxythreonine-4-phosphate-dehydrogenase-2
MTQDATPSRIPTLAVTLGDVAGIGPEITAKMLLGHDELRQRARLLVVGDAAVLAQAVQAVGGDPARVRVIATPAEATNQPGSIEVIQAGPSLAHVPPGQLSAEAGDGSVRYVTTACALARDGLIDGIVTAPLNKAAMHMAGHKWPGHTELLAHEFGVKTFSLVLSAGDLYIFHATTHVSLRQAIEDVNPQRMRAVLRLAGSFARALGRADHPVAVAGLNPHAGENGIFGTEDAEILAPAVAQANAEGILAAGPIPADALFPQAVRGKWKFVIACYHDQGHAPFKSVYGDDGVNITVGLPVVRVSVDHGTAFDIAGKGIAREDSLVLAAERAAQLAPGWHQVWETARSTTGG
>LR134326.1|VEF43132.1|3047108_3048326_-|Uncharacterized-protein-conserved-in-bacteria
MGGPYIGIVADDLTGSGDTAVQFVRAGWATQLSVGGAEQALADPAVRQAEVLAVTTHSRPLAAADAAAVVRGEVERLRAAGVQRLYKKVDSTLRGAFKAEIDAARLAWGEDAIAVVCPAFPVTGRTVRQGVLYVGDRPVTETSAATDPVTPVTESHIPTLLGCAQLAAQAGETPAELARRIAAAAPVVVVDALDDADVQRLARAIGVLGQRAVPVGSGGLAAPLARVWAGGQAAGPVLVVVTSQHSAARQQAAALQHAGARTWAPTLAQLADDRNWAAWTAEVEAAEHGMPAVDALMLLAPEGRLAGLDADSVARRLGELAARLVLAHGAAGVVATGGDGASAVLAALQASGIALVDEVTGGVPLGTLTGGQAAGLPVVTKAGGFGEQDVLIRAAQAIRERRFTK
>LR134326.1|VEF43134.1|3048326_3049349_-|2-keto-3-deoxygluconate-permease
MTTEVSRVPFYTTMMKVPGGLMLLPLILGSLLGTFAPDALAIGGFTTALFKNSALPLIALLIFATGTQVNMRTGGPILATAGTILLMKTLVPATLIILLGHFVGLDGVMGISILAMLAAFDNSNGGLWLAYTGQYGDSRDRGAYVASAVNDGPFFSLLFLGASGLADIPTIALVAALVPFLLGVVVGNLDIEWRNVLKPVPNIVIPFFAFALGTGINLGAVISGGMSGLVLGLLISPITGALVYFGYRYILRRGGKSGLGFAAGTTAGNAIATPAVVAAADPSFQPYVATATAQVAACVLISSILAPVLASYFLKRAGELKPVEQEPQDERAGQPAEVSL
>LR134326.1|VEF43136.1|3049598_3050525_-|ectoine-hydroxylase
MISPAQDPYASRTDRSSAIIARQDPVVYGEGKFADALSADQVQSYERDGFLLLENLFSDEEVAALLAEVERMTRDPAIVRREEAITEPGSNAVRSIFMVHVLSPILGRLVRDPRLANAARQILGSEVYIHQSRANMKPGFKGKEFYWHSDFETWHVEDGMPSMRALSCSVLLTDNNETNGPLMLVPGSHRQFISCVGETPRDHYKQSLKKQEYGVPDPVSLQLLAEQGGISTMTGKAGSVVFFDCNTMHGSNSNISPWPRANVFMVYNSMENTLNPPKYGLNPRPEHIATRQAFKAVRPLDSLKLVER

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Crispr_ID: LR134326_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134326_5

3624584-3624670

Orphan

Consensus_repeat	Method
CTGTCCCCGCGGGGACAGGCACACT	CRISPRCasFinder

1 spacers

The CRISPR arrays of LR134326_5

>merge|LR134326|5|3624584-3624670|CRISPRCasFinder
CTGTCCCCGCGGGGACAGGCACACTGCCGTACGCCATCGACGCTAGCCCGCCAAGACGGTATCTGTCCCTGCGGGGACAGGCACACT

>LR134326|5|5|3624584-3624670|CRISPRCasFinder
CTGTCCCCGCGGGGACAGGCACACT	GCCGTACGCCATCGACGCTAGCCCGCCAAGACGGTAT
CTGTCCCTGCGGGGACAGGCACACT

Protein	Signature genes	Signature genes Name	Protein_function
LR134326.1\|VEF44194.1\|3632885_3633926_-\|alkanesulfonate-transporter-substrate-binding-subunit	unknown	unknown	gnl\|CDD\|270367
LR134326.1\|VEF44200.1\|3636014_3636341_-\|DNA-binding-protein,-YbaB/EbfC-family	unknown	unknown	gnl\|CDD\|234669
LR134326.1\|VEF44178.1\|3622997_3623897_+\|HTH-type-transcriptional-activator-CmpR	unknown	unknown	gnl\|CDD\|223656
LR134326.1\|VEF44186.1\|3628900_3629944_-\|Carbamoyl-phosphate-synthase-small-chain	unknown	unknown	gnl\|CDD\|237139
LR134326.1\|VEF44180.1\|3623907_3624552_+\|Phosphoglyceromutase	unknown	unknown	gnl\|CDD\|366010
LR134326.1\|VEF44184.1\|3625647_3628890_-\|Carbamoyl-phosphate-synthase-large-chain	unknown	unknown	gnl\|CDD\|235393
LR134326.1\|VEF44164.1\|3614126_3614603_-\|Transcript-cleavage-factor-greA	unknown	unknown	gnl\|CDD\|234693
LR134326.1\|VEF44196.1\|3634031_3635282_-\|Formyl-coenzyme-A-transferase	unknown	unknown	gnl\|CDD\|367110
LR134326.1\|VEF44190.1\|3631285_3632080_-\|Putative-aliphatic-sulfonates-transport-permease-protein-ssuC	unknown	unknown	gnl\|CDD\|223673
LR134326.1\|VEF44162.1\|3613169_3613772_+\|RNA-binding-protein-YhbY	unknown	unknown	gnl\|CDD\|198171
LR134326.1\|VEF44172.1\|3618759_3620082_+\|Phosphoglycerate-transport-regulatory-protein-pgtC-precursor	unknown	unknown	gnl\|CDD\|270236
LR134326.1\|VEF44198.1\|3635356_3635965_-\|Recombination-protein-RecR	unknown	unknown	gnl\|CDD\|234616
LR134326.1\|VEF44170.1\|3618341_3618659_+\|Uncharacterised-protein	unknown	unknown	unknown
LR134326.1\|VEF44182.1\|3624732_3625497_-\|Uncharacterized-oxidoreductase-SAV2478	unknown	unknown	gnl\|CDD\|235910
LR134326.1\|VEF44166.1\|3615232_3616864_+\|Aspartate-chemoreceptor-protein	unknown	unknown	gnl\|CDD\|185001
LR134326.1\|VEF44168.1\|3616894_3618208_-\|Putative-pyrimidine-permease-RutG	unknown	unknown	gnl\|CDD\|132655
LR134326.1\|VEF44176.1\|3621864_3622950_+\|Spermidine/putrescine-import-ATP-binding-protein-PotA	unknown	unknown	gnl\|CDD\|226361
LR134326.1\|VEF44192.1\|3632083_3632893_-\|Aliphatic-sulfonates-import-ATP-binding-protein-SsuB	unknown	unknown	gnl\|CDD\|224041
LR134326.1\|VEF44188.1\|3630281_3631244_+\|Transaldolase	unknown	unknown	gnl\|CDD\|235381
LR134326.1\|VEF44174.1\|3620158_3621868_+\|Spermidine/putrescine-transport-system-permease-protein-PotB	unknown	unknown	gnl\|CDD\|224099

Protein	Function_ID	Function_description	E-value
LR134326.1\|VEF44194.1\|3632885_3633926_-\|alkanesulfonate-transporter-substrate-binding-subunit	gnl\|CDD\|270367	cd13649, PBP2_Cae31940, Substrate binding domain of an uncharacterized protein similar to ABC-type transporter for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily. This subfamily includes the periplamic-binding protein Cae31940 which is phylogenetically similar to the ThiY/THI5 family. ThiY is the periplasmic N-formyl-4-amino-5-(aminomethyl)-2-methylpyrimidine (FAMP) binding component of the ABC transport system (ThiXYZ). FAMP is imported into cell by the transporter, where it is then incorporated into the thiamin biosynthetic pathway. The closest structural homologs of ThiY are THI5, which is responsible for the synthesis of 4-amino-5-(hydroxymethyl)-2-methylpyrimidine phosphate (HMP-P) in the thiamin biosynthetic pathway of eukaryotes, and periplasmic binding proteins involved in alkanesulfonate/nitrate and bicarbonate transport. After binding the ligand, They interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ThiY/THI5 proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	2.02712e-131
LR134326.1\|VEF44200.1\|3636014_3636341_-\|DNA-binding-protein,-YbaB/EbfC-family	gnl\|CDD\|234669	PRK00153, PRK00153, YbaB/EbfC family nucleoid-associated protein.	6.20353e-44
LR134326.1\|VEF44186.1\|3628900_3629944_-\|Carbamoyl-phosphate-synthase-small-chain	gnl\|CDD\|237139	PRK12564, PRK12564, carbamoyl-phosphate synthase small subunit.	0
LR134326.1\|VEF44180.1\|3623907_3624552_+\|Phosphoglyceromutase	gnl\|CDD\|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	1.32049e-70
LR134326.1\|VEF44184.1\|3625647_3628890_-\|Carbamoyl-phosphate-synthase-large-chain	gnl\|CDD\|235393	PRK05294, carB, carbamoyl-phosphate synthase large subunit.	0
LR134326.1\|VEF44164.1\|3614126_3614603_-\|Transcript-cleavage-factor-greA	gnl\|CDD\|234693	PRK00226, greA, transcription elongation factor GreA; Reviewed.	7.10406e-83
LR134326.1\|VEF44196.1\|3634031_3635282_-\|Formyl-coenzyme-A-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	4.60342e-142
LR134326.1\|VEF44190.1\|3631285_3632080_-\|Putative-aliphatic-sulfonates-transport-permease-protein-ssuC	gnl\|CDD\|223673	COG0600, TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism].	8.9481e-72
LR134326.1\|VEF44162.1\|3613169_3613772_+\|RNA-binding-protein-YhbY	gnl\|CDD\|198171	smart01103, CRS1_YhbY, Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly. GFP fused to a single-domain CRM protein from maize localises to the nucleolus, suggesting that an analogous activity may have been retained in plants. A CRM domain containing protein in plant chloroplasts has been shown to function in group I and II intron splicing. In vitro experiments with an isolated maize CRM domain have shown it to have RNA binding activity. These and other results suggest that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes. YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome.	1.06237e-30
LR134326.1\|VEF44172.1\|3618759_3620082_+\|Phosphoglycerate-transport-regulatory-protein-pgtC-precursor	gnl\|CDD\|270236	cd13518, PBP2_Fe3_thiamine_like, Substrate binding domain of iron and thiamine transporters-like, a member of the type 2 periplasmic binding fold superfamily. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. On the other hand, thiamin is an essential cofactor in all living systems. Thiamin diphosphate (ThDP)-dependent enzymes play an important role in carbohydrate and branched-chain amino acid metabolism. Most prokaryotes, plants, and fungi can synthesize thiamin, but it is not synthesized in vertebrates. These periplasmic domains have high affinities for their respective substrates and serve as the primary receptor for transport. After binding iron and thiamine with high affinity, they interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The iron- and thiamine-binding proteins belong to the PBPI2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.02894e-39
LR134326.1\|VEF44198.1\|3635356_3635965_-\|Recombination-protein-RecR	gnl\|CDD\|234616	PRK00076, recR, recombination protein RecR; Reviewed.	7.18255e-106
LR134326.1\|VEF44178.1\|3622997_3623897_+\|HTH-type-transcriptional-activator-CmpR	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	7.08863e-33
LR134326.1\|VEF44182.1\|3624732_3625497_-\|Uncharacterized-oxidoreductase-SAV2478	gnl\|CDD\|235910	PRK07024, PRK07024, SDR family oxidoreductase.	4.78988e-141
LR134326.1\|VEF44166.1\|3615232_3616864_+\|Aspartate-chemoreceptor-protein	gnl\|CDD\|185001	PRK15041, PRK15041, methyl-accepting chemotaxis protein.	5.29214e-118
LR134326.1\|VEF44168.1\|3616894_3618208_-\|Putative-pyrimidine-permease-RutG	gnl\|CDD\|132655	TIGR03616, Putative_pyrimidine_permease_RutG, pyrimidine utilization transport protein G. This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the uracil-xanthine permease family defined by TIGR00801. As well as the The Nucleobase:Cation Symporter-2 (NCS2) Family (TC 2.A.40).	0
LR134326.1\|VEF44176.1\|3621864_3622950_+\|Spermidine/putrescine-import-ATP-binding-protein-PotA	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	3.76041e-148
LR134326.1\|VEF44192.1\|3632083_3632893_-\|Aliphatic-sulfonates-import-ATP-binding-protein-SsuB	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	5.87905e-116
LR134326.1\|VEF44188.1\|3630281_3631244_+\|Transaldolase	gnl\|CDD\|235381	PRK05269, PRK05269, transaldolase B; Provisional.	0
LR134326.1\|VEF44174.1\|3620158_3621868_+\|Spermidine/putrescine-transport-system-permease-protein-PotB	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	1.44555e-89

>LR134326.1|VEF44180.1|3623907_3624552_+|Phosphoglyceromutase
MTEIWFIRHGETDWNRQRRLQGWQDIPLNESGREQARLLAERLRDTASEHPFAALYSSDLKRAHDTAASLSAALQLRVRTEPGIRERGFGVLEGLEMENLEQQAPQAAQAWRSRDPLRALEGGETLGQFQARIIATVDDLAARHAGERILAVTHGGALDIIWRHASGVPLDAPRYAALLNVSINRVAIAQRKWEVLGWGDVEHIGAETGNDVTP
>LR134326.1|VEF44178.1|3622997_3623897_+|HTH-type-transcriptional-activator-CmpR
MEIYQIRAFVTVARLGNLTKAAEALSLTQPAVTAQLKALEQSLGVALFDRAAGRLSLAKAGEALLPTAEALLVLGAQLKSEARQLQGQLQGVIDLGVPSEQPDFLRLGELAAALRQRLPLVELKTHVLPSTALLEQVGTARLAGALTIVAHPPRGVTWHALRSVRYRIALPASLADTLKRAGWRDIAQLPWLDGPSGSHLHLLLRDMFERHGLAPRVVMQNDDQSNLDALVRAGAGCALLREETALAGAAAGDFIVWGQARADATLGFIAPPEQAGEPMLVALISMIQKIWKPGAAVAT
>LR134326.1|VEF44176.1|3621864_3622950_+|Spermidine/putrescine-import-ATP-binding-protein-PotA
MKKVSVECRNIRLSYGRNEVLKDISIHIEPGEFFALLGPSGSGKSTLLRLIAGFNRQSHGQLLVDGRDIGATPPWDRNIGMVFQNYALWPHMTVWDNVAFGLVERRLPRAEIRDKVAAALELVGLADFGRRRPNQLSGGQQQRVALARTIVIEPQVLLLDEPLSNLDKKLRVQMRQDLLSLQRRLGITTIFVTHDQEEAMTTADRMAVLDHGVVQQIGAPSTLFDYPVNRFVANFVGTMNVLEGEVRERSRGGVVLAVDGVGELHLPVNGDAPQAGRLAASFRPHTVLIEMADGTGDARYVWLPGVVESSEFLGEFTRYQVQVGEQRLTADQHHLAGLSPFPVGAPVAVGLEPTQIRLLAA
>LR134326.1|VEF44174.1|3620158_3621868_+|Spermidine/putrescine-transport-system-permease-protein-PotB
MTSTGTFRLPAGPALAALLVLAFLALFLVFPVGTVFYTAFVNADGSFTLGHFGAFFNQPLMKEAFFNSLYVAGWSSLLASLIAVPLAYFTVRFEFRGALLIQTLGVLPLIMPPFVGAVAMQLIFGRSGSVNLLLDDWLGITLPFMDGLNGVIFVESLHYFPFILMNLVVALRNIDGSMEEAAFNLGSRGFRLFCRIIFPLALPGYLAGTSLVFVKVFDDLGTPLVLGTTNMLAPQAYLRITQVGLEDPLGYVISVIMIGFSILALWLSARVLKGKDYSTLQKGGNAIHKRRLRPVESVLAYAWIGAVLLLVLSPHLGVLLLSLASVWSYAPLPDGYTLAHYTAVFTESQGMIANTLLYCGLAAGVDVVLGTAIAYLMLRTRLPARQWLDFIASAALAIPGIVLAIGYLRTFRGVEIPGTGVLLTSSWVLIMIAYSVRRLPYALRSCVAALQQINVSLEEAAESLGASRLRTIRRIVVPLMAGGMLAGFVTSFITAAVELSATIMLVTRDSQAPMSYGIYLYMQSAAGRGPGAALGVLAVVAVGIGTYVSHLLVERASARQRPARSGESS
>LR134326.1|VEF44172.1|3618759_3620082_+|Phosphoglycerate-transport-regulatory-protein-pgtC-precursor
MQALRPVLAAAIMAACAPALAGTVTVITSFPKDLTQAYKAAFEKAHPDIKLEILNKNTVSGIAFVRETPAGQRPEVFWASAPDAFEVLGRDKLLAKAPDVANPAVPDKIGSYPINDPSGMYMGQALAGYGIIYNTRYIKANKLPAPVEWKDLLAPHWFGHVGITAPSRSGTMHLTVETILQGEGWNDGWGTLLRMSGNASAVTERSFGVPDGVNNGQFGAGPVIDFFGLSSKYSKFPVDFVYPSETAIVPANIALIEGAKNTEEGKKFIAFTLSQAGQELLLEPKISRLPVLPYAALAGKIPPGYPDPAEIAKRSKVHFDADLSQARYYVVQSLFDQTITFRLKELQAATKAIYDAEAKLGERAGQGKAAELLAQARQLAWTPLVDAQRAADPAFLKLFAGNKKDAAVNQQITQLEGEWNGKARANYEQAQKLAREAAAL
>LR134326.1|VEF44170.1|3618341_3618659_+|Uncharacterised-protein
MTVSSVSSRISAGAFDQYARQLRDRAAASGAKDEAGSPAAEALQALQRQLAAIMRQMRQVRESNATAEQQARQLQDLNRQAFAIQGQIQKLLEEQLRLAQRLAAR
>LR134326.1|VEF44168.1|3616894_3618208_-|Putative-pyrimidine-permease-RutG
MSNTYFPRWRLADDTVPGAVIAPDERLSWPKNIAMGAQHVVAMFGSTVLAPLLMGFDPNVAILMSGIGTLIFFLFVGGRVPSYLGSSFAFIGGVVAVTGYVAPGANANIGVALGAIIACGLVYALIGLVVWAASARGNGARWIEAMMPPVVTGAVVAVIGLNLAPIAAKGAMGSSGFEASMALMTILCVGGIAVYTRGMVQRLLILVGLVLACVIYAVCANGLGLGAPMDFAKVAAAPWFGLPSFAAPVFEPQAMGLIVPVAIILVAENLGHVKAVAAMTGQDLDRYVGRAFVGDGVATMVSGAVGGTGVTTYAENIGVMAVTRIYSTLVFVVAAVIALVLGFSPKFGALIQTIPGPVLGGMSVVVFGLIAIAGARIWVVNQVDFSDNRNLIVAAVTLVLGAGDFSVKLGDFSMNGIGTATFGAIILYALLGLARRR
>LR134326.1|VEF44166.1|3615232_3616864_+|Aspartate-chemoreceptor-protein
MLERIKVRTAMVAVFACFLAVLMLSGALTWRNAGRSAAEIEGLNQVAVNQVDPLFEASGAALRARVALLEALANLQANHLDPVATLHQQAGAAQRQAATQFQRYVDVPKEPAAAELAATLQTRWRAYQSVLDELAAAVDAGQAEPALAAMNRAQQAEHAFQRDMEAFLARVQAHSDEVRSGAEDTHVVARWSAIALAALGVLLTLAGWLFVRRAVLRPLLEAGHHFDRIADGDLTARIEVRSANEIGALFAALKRMQEGLTRTIAVMRRGVDEINVGAAEISAGNANLSSRTEEQAAALEETAATMEELATTVKQNADNAAQANQLAAVSMQVAQRGGESVAQVVQTMHGISASSRQIADIVTVIDGIAFQTNILALNAAVEAARAGEQGKGFAVVAGEVRSLAQRAAQAAKEIKALIESSVATVRAGSQQVASAGGTMDEVVASVQRVADIMGEISAASAQQASGIDQVSLAISQMDETTQQNAALVEQAAAAATAMEEQARHLAAAAAVFRTQGGAIIDVAAAPLAGPAGDHAALPPAAAR
>LR134326.1|VEF44164.1|3614126_3614603_-|Transcript-cleavage-factor-greA
MSAIPLTVRGAERLQQELHRLKTVERPAVISAIAEARAQGDLSENAEYDAARERQGFIEGRISELEGTLSNAHLIDPTALDAEGRAVFGATVEIEDLDSGDRLTYQIVGDVEADIKSNLISVSSPVARALIGKSEGDVVEVKVPAGVREYEVIGVRYL
>LR134326.1|VEF44162.1|3613169_3613772_+|RNA-binding-protein-YhbY
MPILELTSRERSDLRSAAHPLRPVVLIGDNGLTDAVLKEIDLALTAHELIKVRAGGDDREAREAMLATICDTLSCAAVHHLGKTLILFRPDLRAAAAKAAADTPAKRRPSEPHTPKKMAAEGKRLTKTRPARKAAEAAAPAAGARPGRDDLNQAGRPARPSTRKASPGHAIPRRSGSALSLRAGARGGLAGRKPARANKR
>LR134326.1|VEF44182.1|3624732_3625497_-|Uncharacterized-oxidoreductase-SAV2478
MQHVFITGASSGLGQALARRYAADGARLGLLGRRAQALEALASSLPGQHRCYAVDVRDRAALHAAAQDFIAHCGGRVDVVIASAGVSAGTLTEAGEDYAVFKEIVDTNLLATVATFEPFIAGMRAARAGRLVGIASVAGVRGLPGAGAYSASKAAVATYCESLRLELAQAGVRVVTIAPGYVKTAMTAHNPYAMPFLMEADAFAGRAHAAIARGVSYRVIPWQMGVVAKLMRLLPDAVYDRLARDAPRKPRRGQ
>LR134326.1|VEF44184.1|3625647_3628890_-|Carbamoyl-phosphate-synthase-large-chain
MPKRTDLKSILIIGAGPIIIGQACEFDYSGAQACKALKAEGYRTILVNSNPATIMTDPETADVTYIEPITWQAVEKIIEREKPDALLPTMGGQTALNCALDLAHHGVLKKHNVELIGANEHAIEKAEDRQKFKQAMTDIGLESAKSGVAHSMDEAWEVQRRIAADIGTAGFPVVIRPSFTLGGSGGGIAYNAEEFEVICRRGLEASPTKELLIEESLLGWKEFEMEVVRDKADNCIIVCSIENLDPMGVHTGDSITVAPAQTLTDKEYQIMRNASIAVLREIGVDTGGSNVQFAVNPQNGRMIVIEMNPRVSRSSALASKATGFPIAKVAARLAVGYTLDELRNEITGGATPASFEPTIDYVVTKVPRFAFEKFPQADARLTTQMKSVGEVMAMGRTFQESFQKALRGLEVGVDGLNQKTTDREKLQIELGEPGPERIWYVGDAFAQGFTLDEVHGLTRIDPWFLAQIKEIVDIELALEQKTLADLDYATLWELKRRGFSDRRLAFLLDSSESEVRKLRHQLNVRPVYKRVDTCAAEFATNTAYMYSTYEEECESQPTDRKKIIVLGGGPNRIGQGIEFDYCCVHAALALREDGYETIMVNCNPETVSTDYDTSDRLYFEPLTLEDVLEIVHKENPVGMIVQYGGQTPLKLARALEANGVPIIGTSPESIDVAEDRERFQKLLNKLGLRQPPNRTARTEAEALAHASEIGYPLVVRPSYVLGGRAMEIVHEQQDLERYMREAVKVSNDSPVLLDRFLNDATEVDVDCLADGQTVFIGGVMEHIEQAGVHSGDSACSLPPYSLSAEVIAEIKRQTTMMAKALNVSGLMNVQFAIQGGDVYVLEVNPRASRTVPYVSKATGLQLAKIAARAMAGRTLADQGITREVVPPYFSVKEAVFPFVKFPGVDTILGPEMKSTGEVMGVGNSFGEAFVKSQLAAGVRLPDSGTVFISVRNQDKPRAVEVARGLHNLGFKLVATRGTAAEIEAAGIPVQVVNKVTEGRPHIVDMVKNGEVSLVINTVEERRNAIADSRTIRTQALANRITFFTTIAGARAAVEGMQFMRQGLGLQVYPLQELHAGLTAQ
>LR134326.1|VEF44186.1|3628900_3629944_-|Carbamoyl-phosphate-synthase-small-chain
MAEVVFNTSMTGYQEILTDPSYAGQTVMLTYPHIGNTGVNPEDVEANRVYAAGLVVRDCPARVSNFRATQSLPEYLNAQGIVAIAGIDTRKLTRILRESGAQGSCILVGEDAERAVELARGFPGMSGQDLAKVVSIKERADWTQGTWELGSGYTQPAQDRFHVVAYDYGVKSNILRLLADRGCRVTLVPAQTTAEEAFKLQPDGVFLSNGPGDPEPCDYAVDATRAFLERKLPVFGICLGHQLMGLALGGKTVKMKTGHHGANHPVQDVQSGRVFITSQNHGFAVDAATLPANTRVTHISLFDGTLQGFELTDRPAFCFQGHPEASPGPHDIIVLFDKFISLMAGQK
>LR134326.1|VEF44188.1|3630281_3631244_+|Transaldolase
MPSQLEALRRHTVVVADTGDFEAMRALRPTDATTNPSLILKAVQQEAYRPLLVQTARAHQGASPAEITDRLLVAFGRQILDIVPGRVSTEVDARLSFDTRATVERARGLIALYQAAGVPRERVLIKIASTWEGIQAARVLQAEGIRCNLTLLFCLPQAAACADAGVQLISPFVGRIYDWHKKNAGAEWVEDARRGANDPGVQSVSRIYRYYKRFGIETEIMGASFRNVDQILALAGCDLLTISPELLTRLSQTEGEVPAALSPQAGHDDADAVRLDGGEVAFRTQLNEDAMASEKLSEGIRLFVADARKLDALVESHGAA
>LR134326.1|VEF44190.1|3631285_3632080_-|Putative-aliphatic-sulfonates-transport-permease-protein-ssuC
MSKLIKPGSLSLRFWQLLLFVVILLVWHAASRDPKVAFFFGEPLKVWGRIWAWFVSNGDIYGHLWVTLSETVLAFFIGTVSGLGFGLWLGLSPGASAILDPYIKAANSMPRVILAPIFGMWFGLGIWSKVALAVTLVFFIVFFNVYQGVREVSPTLLDNARMLGARRRQLLRHVYLPSATSWVFSSLHTSVGLAFVGAVVGEYLGSASGVGYLILQAEGTFDVNTVFAGIVVLTAFALLLDYVVGMGEKRLMKWQPKSGETEKL
>LR134326.1|VEF44192.1|3632083_3632893_-|Aliphatic-sulfonates-import-ATP-binding-protein-SsuB
MAEAALSLEGITCTFIAREDRSRRYTAVQDTSLAVAPGEFVSVVGPTGCGKSTLLNVGAGLLAPSSGTVRVFGQALAGINERAGYMFQGEALLPWRSALENVVAGLDFAGVPRAEADERGREWMRRVGLGGFETRYPHQMSGGMRKRVMLAQTLIRDPDIILMDEPFSALDIQTRQLMENEVLDLWMAKRKAVLFITHDLDEAIAMSDRVIVLSAGPGTHPIGEFAIDLPRPRDVAEVRTHPRFVELHAAIWGVLREEVLKGYAQQKRA
>LR134326.1|VEF44194.1|3632885_3633926_-|alkanesulfonate-transporter-substrate-binding-subunit
MSVTRRELLKLAGAAGAMSLAPAIVRAQKLEKAKVQIAVGGKPLIYYLPLTIAEVKGFFKDEGLDVSIADFAGGSKALQAVVGGSADVVSGAFEHTLSLQAKGQFYRAFALQGRAPMIGVGVSKKNLPGYKGPADLKGRKIGVTAPGSSTNMVVNFFLAKHGLKASDVSFIGVGAGAGAVTALRSGQIDAISNTDPVVSMLETSGDIQIIVDTRTLKDTKEIFGGNMPAGCLYAPQAFVDANPNTAQALTNAIVRADKWIQKAGADEIAKAVPEGYLLGDPAVYKAAIGKSMEGLSPDGVIPEDGAATALKALAAFVPDFDAAKVDPAKAWTNEYTRRANEKYPNG
>LR134326.1|VEF44196.1|3634031_3635282_-|Formyl-coenzyme-A-transferase
MSALKGLKVLELGTLIAGPFAARMFGEFGAEVIKVETPHGPDGTGGGDPIRSWRHLHRGDSLWWTVQARNKQSIALNLKKPRAQEIARRLALEADVVVENYRPGVLEKWGLGYEQLRAINPATIMVRLSGYGQTGPLRDLPGFGAIGESMGGLRYVSGHPDRPPVRVGISIGDSLAALHGVIGALMALRHRDATGGRWNGATGEQCQAGQGQMVDVALYESVFNMMESLVPEYDVAGVVRERTGGALPGIVPSNTYTTRDGQNIVIAGNGDAIFHRLMLAIGRSDLAHDPQLERNDGRARRATEIDSAIQRWCDTHTIEQALATLRAADVPVGKIYSVADMFTDPQFLARGMIEQHHFPDGSPVKLPAVVPKLSETPGGTRWLGPRLGEHTEEVLRSLGYDAAAIAELAQTGAIGR
>LR134326.1|VEF44198.1|3635356_3635965_-|Recombination-protein-RecR
MDPQLPEPEPLIALIEALRRLPGVGVRSARRMAYHLLQHDLQGADMLGRALSGAVQHLRHCARCNSFTEDEVCATCANPKRDPGLLCIVETPADQNMIESSHGYRGLYYVLMGRIAPLEGVGPRELDFQRVIERACDGVVQEVILATNFTAEGETTAHFLGDALSERGLKVTRLARGVPAGSELEYVDAGTIAWALMERRST
>LR134326.1|VEF44200.1|3636014_3636341_-|DNA-binding-protein,-YbaB/EbfC-family
MMKGQLAGLMRQAQQMQENMKKAQDALAEIQVEGAAGGGLVKVTMTCRHDVKRVAIDPSLLGEDKDMLEDLVAAAFNDALRKAEATSQEKMASVTAGMPLPPGMKLPF

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Crispr_ID: LR134326_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134326_6

3743313-3743437

Orphan

Consensus_repeat	Method
GTGCCTGTCCCCGCAGGGACAGGC	CRISPRCasFinder

2 spacers

The CRISPR arrays of LR134326_6

>merge|LR134326|6|3743313-3743437|CRISPRCasFinder
GTGCCTGTCCCCGCAGGGGGACTGGCACCCGCAAACTCTCGGGGTGCCTGTCCCCGCAGGGACAGGCACCAATCCACCTCCACGCCTGCCACTTCCCCGGCGTGCCTGTCCCCGCAGGGACAGGC

>LR134326|6|6|3743313-3743437|CRISPRCasFinder
GTGCCTGTCCCCGCAGGGGGACTG	GCACCCGCAAACTCTCGGG
GTGCCTGTCCCCGCAGGGACAGGC	ACCAATCCACCTCCACGCCTGCCACTTCCCCGGC
GTGCCTGTCCCCGCAGGGACAGGC

Protein	Signature genes	Signature genes Name	Protein_function
LR134326.1\|VEF44404.1\|3746368_3747244_+\|EamA-like-transporter-family	unknown	unknown	unknown
LR134326.1\|VEF44414.1\|3750920_3754382_-\|Uncharacterized-protein-involved-in-outer-membrane-biogenesis	unknown	unknown	gnl\|CDD\|377502
LR134326.1\|VEF44389.1\|3736924_3737644_-\|N-carbamoylsarcosine-amidase	unknown	unknown	gnl\|CDD\|238497
LR134326.1\|VEF44399.1\|3744221_3744527_-\|Uncharacterised-protein	unknown	unknown	gnl\|CDD\|379321
LR134326.1\|VEF44401.1\|3744590_3744896_-\|Uncharacterised-protein	unknown	unknown	gnl\|CDD\|379321
LR134326.1\|VEF44393.1\|3739075_3741730_-\|Aconitate-hydratase	unknown	unknown	gnl\|CDD\|236445
LR134326.1\|VEF44377.1\|3729498_3730884_+\|2-methylcitrate-dehydratase	unknown	unknown	gnl\|CDD\|377179
LR134326.1\|VEF44408.1\|3748835_3749339_-\|Putative-peroxiredoxin-sll1621	unknown	unknown	gnl\|CDD\|239311
LR134326.1\|VEF44402.1\|3745364_3746372_+\|Biotin-synthase	unknown	unknown	gnl\|CDD\|273075
LR134326.1\|VEF44379.1\|3730914_3731910_-\|Argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|270296
LR134326.1\|VEF44387.1\|3735912_3736914_-\|Uncharacterized-GTP-binding-protein-YjiA	unknown	unknown	gnl\|CDD\|223597
LR134326.1\|VEF44406.1\|3747357_3748758_-\|Uncharacterized-MFS-type-transporter-ycaD	unknown	unknown	gnl\|CDD\|341030
LR134326.1\|VEF44391.1\|3737677_3739051_-\|D-hydantoinase	unknown	unknown	gnl\|CDD\|238627
LR134326.1\|VEF44395.1\|3741959_3742853_+\|Carboxyvinyl-carboxyphosphonate-phosphorylmutase	unknown	unknown	gnl\|CDD\|119340
LR134326.1\|VEF44381.1\|3731978_3733355_-\|MmgE/PrpD-family	unknown	unknown	gnl\|CDD\|377179
LR134326.1\|VEF44397.1\|3743505_3744096_-\|HTH-type-transcriptional-repressor-nemR	unknown	unknown	gnl\|CDD\|224228
LR134326.1\|VEF44412.1\|3750018_3750903_-\|Carboxymethylenebutenolidase	unknown	unknown	gnl\|CDD\|223489
LR134326.1\|VEF44410.1\|3749577_3750009_+\|Uncharacterised-protein	unknown	unknown	unknown
LR134326.1\|VEF44383.1\|3733351_3734737_-\|Fumarate-reductase-flavoprotein-subunit-precursor	unknown	unknown	gnl\|CDD\|273816
LR134326.1\|VEF44385.1\|3734755_3735775_-\|Argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|270296

Protein	Function_ID	Function_description	E-value
LR134326.1\|VEF44414.1\|3750920_3754382_-\|Uncharacterized-protein-involved-in-outer-membrane-biogenesis	gnl\|CDD\|377502	pfam05359, DUF748, Domain of Unknown Function (DUF748).	2.18641e-36
LR134326.1\|VEF44389.1\|3736924_3737644_-\|N-carbamoylsarcosine-amidase	gnl\|CDD\|238497	cd01015, CSHase, N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.	9.42667e-40
LR134326.1\|VEF44399.1\|3744221_3744527_-\|Uncharacterised-protein	gnl\|CDD\|379321	pfam13663, DUF4148, Domain of unknown function (DUF4148).	0.000118779
LR134326.1\|VEF44401.1\|3744590_3744896_-\|Uncharacterised-protein	gnl\|CDD\|379321	pfam13663, DUF4148, Domain of unknown function (DUF4148).	0.00044027
LR134326.1\|VEF44393.1\|3739075_3741730_-\|Aconitate-hydratase	gnl\|CDD\|236445	PRK09277, PRK09277, aconitate hydratase AcnA.	0
LR134326.1\|VEF44377.1\|3729498_3730884_+\|2-methylcitrate-dehydratase	gnl\|CDD\|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	6.11988e-64
LR134326.1\|VEF44408.1\|3748835_3749339_-\|Putative-peroxiredoxin-sll1621	gnl\|CDD\|239311	cd03013, PRX5_like, Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5 suggests that it may have an important antioxidant role in organelles that are major sources of reactive oxygen species (ROS), as well as a role in the control of signal transduction. PRX5 has been shown to reduce hydrogen peroxide, alkyl hydroperoxides and peroxynitrite. As with all other PRXs, the N-terminal peroxidatic cysteine of PRX5 is oxidized into a sulfenic acid intermediate upon reaction with peroxides. Human PRX5 is able to resolve this intermediate by forming an intramolecular disulfide bond with its C-terminal cysteine (the resolving cysteine), which can then be reduced by TRX, just like an atypical 2-cys PRX. This resolving cysteine, however, is not conserved in other members of the subfamily. In such cases, it is assumed that the oxidized cysteine is directly resolved by an external small-molecule or protein reductant, typical of a 1-cys PRX. In the case of the H. influenza PRX5 hybrid, the resolving glutaredoxin domain is on the same protein chain as PRX. PRX5 homodimers show an A-type interface, similar to atypical 2-cys PRXs.	1.07728e-77
LR134326.1\|VEF44402.1\|3745364_3746372_+\|Biotin-synthase	gnl\|CDD\|273075	TIGR00433, biotin_synthase, biotin synthase. Catalyzes the last step of the biotin biosynthesis pathway. All members of the seed alignment are in the immediate gene neighborhood of a bioA gene. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	1.87441e-175
LR134326.1\|VEF44379.1\|3730914_3731910_-\|Argininosuccinate-lyase	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	8.03152e-150
LR134326.1\|VEF44387.1\|3735912_3736914_-\|Uncharacterized-GTP-binding-protein-YjiA	gnl\|CDD\|223597	COG0523, COG0523, Putative GTPases (G3E family) [General function prediction only].	4.74612e-64
LR134326.1\|VEF44406.1\|3747357_3748758_-\|Uncharacterized-MFS-type-transporter-ycaD	gnl\|CDD\|341030	cd17477, MFS_YcaD_like, YcaD and similar transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.74753e-92
LR134326.1\|VEF44391.1\|3737677_3739051_-\|D-hydantoinase	gnl\|CDD\|238627	cd01302, Cyclic_amidohydrolases, Cyclic amidohydrolases, including hydantoinase, dihydropyrimidinase, allantoinase, and dihydroorotase, are involved in the metabolism of pyrimidines and purines, sharing the property of hydrolyzing the cyclic amide bond of each substrate to the corresponding N-carbamyl amino acids. Allantoinases catalyze the degradation of purines, while dihydropyrimidinases and hydantoinases, a microbial counterpart of dihydropyrimidinase, are involved in pyrimidine degradation. Dihydroorotase participates in the de novo synthesis of pyrimidines.	3.34177e-142
LR134326.1\|VEF44395.1\|3741959_3742853_+\|Carboxyvinyl-carboxyphosphonate-phosphorylmutase	gnl\|CDD\|119340	cd00377, ICL_PEPM, Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate lyase (ICL), and 2-methylisocitrate lyase (MICL). Isocitrate lyase (ICL) catalyzes the conversion of isocitrate to succinate and glyoxylate, the first committed step in the glyoxylate pathway. This carbon-conserving pathway is present in most prokaryotes, lower eukaryotes and plants, but has not been observed in vertebrates. PEP mutase (PEPM) turns phosphoenolpyruvate (PEP) into phosphonopyruvate (P-pyr), an important intermediate in the formation of organophosphonates, which function as antibiotics or play a role in pathogenesis or signaling. P-pyr can be hydrolyzed by phosphonopyruvate hydrolase (PPH) to from pyruvate and phosphate. Oxaloacetate acetylhydrolase (OAH) catalyzes the hydrolytic cleavage of oxaloacetate to form acetate and oxalate, an important pathway to produce oxalate in filamentous fungi. 2-methylisocitrate lyase (MICL) cleaves 2-methylisocitrate to pyruvate and succinate, part of the methylcitrate cycle for the alpha-oxidation of propionate.	5.98205e-95
LR134326.1\|VEF44381.1\|3731978_3733355_-\|MmgE/PrpD-family	gnl\|CDD\|377179	pfam03972, MmgE_PrpD, MmgE/PrpD family. This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle.	2.66844e-95
LR134326.1\|VEF44397.1\|3743505_3744096_-\|HTH-type-transcriptional-repressor-nemR	gnl\|CDD\|224228	COG1309, AcrR, Transcriptional regulator [Transcription].	6.75019e-12
LR134326.1\|VEF44412.1\|3750018_3750903_-\|Carboxymethylenebutenolidase	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	6.22453e-65
LR134326.1\|VEF44383.1\|3733351_3734737_-\|Fumarate-reductase-flavoprotein-subunit-precursor	gnl\|CDD\|273816	TIGR01813, Fumarate_reductase_flavoprotein_subunit, flavocytochrome c. This model describes a family of redox proteins related to the succinate dehydrogenases and fumarate reductases of E. coli, mitochondria, and other well-characterized systems. A member of this family from Shewanella frigidimarina NCIMB400 is characterized as a water-soluble periplasmic protein with four heme groups, a non-covalently bound FAD, and essentially unidirectional fumarate reductase activity. At least seven distinct members of this family are found in Shewanella oneidensis, a species able to use a wide variety of pathways for respiraton. [Energy metabolism, Electron transport].	2.21541e-56
LR134326.1\|VEF44385.1\|3734755_3735775_-\|Argininosuccinate-lyase	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	3.91792e-114

>LR134326.1|VEF44395.1|3741959_3742853_+|Carboxyvinyl-carboxyphosphonate-phosphorylmutase
MSSAAKKFRDLLNSAEFIVSPGVYDGYSLRLVQAAGFKTACTSGAALSNALLGIADIGVMGLMENVNHCRMLARSVDIPLTADADTGYGNPVNVFHTVQMFEEAGVAGVNLEDQVSPKRCGHMPGKDVIPLEEMVKKIEAACLARRDDNFVIIARTDALAVEGIEGAARRAQAYAAAGADVIFPDAVRTAEDIGRIVEAAGVPVSVNMGFGVRQRPTTPLIPLPELKRLGVKRISLPRMLPAAAIHGMRSALEEMKQVIATGTPAHRPDLLVGIEDIMELMGYEAMRALEKKLTTLD
>LR134326.1|VEF44393.1|3739075_3741730_-|Aconitate-hydratase
MNASFLHLGTPIHYADVAAAAARSGVELASLPYVIRILLENLLRHRGRGRPVQEAEIEAVAHWQAHISEQISLHVERVILPDSSGLPVLQDLAALRDAVQAGGGDPARVDTRVPVDLIVDHSLQVDAWSTADAVRRNLDAEFARNEQRYRFLKWAQQAFDGLRVFAPGTGIIHQVNLEKLATVVSTSEHGGQQWACPDFVIGGDSHTPMVNGLGVLGWGVGGIDAESALLGRAYTFPIPEVVGVELKGAFRSPVTTTDAALLVTQRLRAEGVTGCMVEFFGEALPGLSVADRATIANMAPEYGATCGFFPVDAQTLDYLRLTGRTAEHIELVRAYCQANGLWRADPAASAVRYARVVRIDLAQAEPCMSGPRRPQDRLPIGQLAEDFRQRLPRPAAEGGFGLDAAALARAPGSAGLRHGSIVVAALTSCTNTSNPSVMLTAALVARAARQRGIAPPAWVKRSLAPGSRTVTDYLAATGLLQDLEALGFGVIGYGCTTCGGKSGPLAPEVAQDIADNQWVVCTVLSGNRNFEGRIHKLARANYIGSPPLVVAYALAGRIDIDFSREPIATDADGQPVWLHELWPGEAQLDEIMARALSPQGFRRVWGLEPEGASQWRALAEVSGQHWQWDDSNYLVEPPFFKAPAQQFGQRLAGARVLGLYGDSLTTDHISPSGEIPAEAPAGRYLLGLGVAQRDFNTYVARRSNFEVMTRATFGNIRIRNLLVPGTEGGYTRHFPSGEQLSIYDASRRYMAAGTPTIVLAGEEYGTGSSRDWAAKGTALLGVRAVLAKSYERIHRANLVGMGVIPFQFERGQGWRELGLDGSETFEFFDVLDGIRQGRPVRVAASRDDGMRVEFSVMPQALTESERELLLQGGIPASVLADYLQ
>LR134326.1|VEF44391.1|3737677_3739051_-|D-hydantoinase
MARPLDTLLANTLVFLEGQGLVPGSIGIADGRIAVIGSHGQDMPAARETIDCQGLWTLPGVIDPHVHFGFGSPETDFETESRNAALGGTTSVISFHRSADIRESFDAVRARAESQSCIDFGFHFGITSRLHVDTLDEISRRFGVSSYKLYMMYKGAAGLSKGFTDIDDGLLWGALNATRAIPGAVLGVHCENVEVIPWLRDPLRAAGRDDLAAWNEQSPDFLEAENVHRVCYFAGKTGTPVNIVHLSSREALREVRRHRHEGRAAPIYVETCPHYLFLDDRSPAGTYAKVNPPVRSAADIDAMWEGVCDGAITTIGSDHVPRKRATKDKDIWAASNGFPGTGMILPILLHEGYHRRQVPLETLMRVASGASARIYGMPAKGRIAVGNDADLVIVDPDLEKTVDPGELESHADYSPYEGMRLKGWPVRTLVRGRTVARDGRIADEARQTPGGRYLRRL
>LR134326.1|VEF44389.1|3736924_3737644_-|N-carbamoylsarcosine-amidase
MSETKRIWDAFLTERDKEVYKAAGYGKRGGFGKRPALFIIDVQYNFCGDKPEDILEGLKQYRTHCGAEAWDAVKHIVPLLELAREKNLPVFYTESGRRNDLLDSGVQVGKNHRGGEKTVLANTHATRTVEELAPLPQDIRIVKQKPSCFFGTIFMSHLNFFDVDTLILVGCTTSGCLRATTVDAYSYNFKVIIPEEASFDRFQSSHAMSLFDLNCKYADVIPTAEVADYLKALPAREAG
>LR134326.1|VEF44387.1|3735912_3736914_-|Uncharacterized-GTP-binding-protein-YjiA
MSTIPITLLTGFLGSGKTSLLRRLIHQPGFARCAVIINEFGEVGLDQALVADQSDDRDIQLLDSGCLCCLASSAIQDTLASLYYRRLRGEIPWFDRVLIETSGLAEPGPIINAVYGDGALARQFRFAGIVTTFDAGFGQVDVQAYAEAKTQLLMADTVVLTKLDLHPEARHLAAWLGELNPTARVYENSLPDDTLARLLLDPAADRPAPAAQGHPSAGAPQASALRHLLAYGIHSVTVDVPDAIGWPAWAAFVHEVQRTFADRLLRLKGVLAFEGQGRMAVHAVHHVFSAPEPAGAVPPALVGKLVFIVRDMEREEVLHAVRHLSGAPPADAA
>LR134326.1|VEF44385.1|3734755_3735775_-|Argininosuccinate-lyase
MNFFNFGFQPGAAHTRRRVTATVLALAAWAALPAQQAAAQPQWPQRPVTLIVPFAPGGPTDITARVLGEALGKEWKQTVVIENRAGAGGTVGAGFAAKAAPDGYTLLLGVTGSHGIAGSLYPSLTYDPKGDFEAISKVVFYPNAIIANPDVPANNLQELIALAKKDPKYQVYGTDGNGTASHLTMELLRERGGFPMQAVQYKGASPLINDIVAGFVPVGITGFPSAEPQVKAGKLKLIALTTDKDYSGNGYPTIAGQGFPGFAAAPWSGIFAPKGTPAPVVQKIAADIKTVMASPAVVEKMQKLGLTPSAVTLADFEAELDRERASWATAVKISGAKVQ
>LR134326.1|VEF44383.1|3733351_3734737_-|Fumarate-reductase-flavoprotein-subunit-precursor
MEFDMEFDVVIVGAGGCGLTAAVAIHDAYPQASIAVLDKAERACGNTVLSSGSIPAAGTRFQEAAGVHDTPRMFQEDLLTIAGEHEAMDLTRALTETSARLVEWLVDSAHVRLTLVETYKHIGHRVHRLHSPPSRRGADLVDDLLRECERRDIPVAWSNAVTGLIASEGRPRGVECATPDGAVTRVGARHVVLASNGYAANKSLLARFVPEVAAAPYGGGTGSEGEAILWGESLGAGLANMKAYQGHASLADPHGSLVTWTVIEKGGIIVDRSGQRFGDESIGYSAFAALELARTGPFWVIADTQVRDVTAAGQEEYAELVAHGGVLEGCLEELCARTGIDAAGLAATLQAARQCAADGGADAHGRAQWGLGPLGERLTATRIGPAIFHTQGGLRVDIDGRVLTDQAGVIDGLWAGGGAACGISGNRGSLGYMSGNGLLSALGLGLRIGQAIASRLGEEQA
>LR134326.1|VEF44381.1|3731978_3733355_-|MmgE/PrpD-family
MTHDFKGSLMAGATPTRALADWCAALRDSRPSEAVLRESARHVLDTLAACAAGMRQPLVRAAIELERGINAQPGPVALFGGPERWTVLESAGLMAVACHALEMDDGNREGSIHPATTVVPAVLALGWQQEADYLAFLCAVVAGFEVAVSIAETLHPHASQRGFQTTPVAGVVGAAAACATLLGLDGAGIESAMGLAASASGGLFAYLAGGGNVKKFHPGHAAREGLRAALMARQGVAQGPRGVIEGRAGLLQAFGGITQWDGSRARERAAPAIARSYLKPYPCCRHIHPAIDAVMALKARAAWQAADVAAIEVETYGAAMPHARLPWDTLEVAQLSFPWVMALACVDGEVTLAGFSEAARTRPDINALAARVSVAQTQECDSLYPASGPARVTLRLRSGERLSEWVADPLGSADRPLADEALDRKAAEAFGLAFPAARVRALIGQLRRLESWPLAELN
>LR134326.1|VEF44379.1|3730914_3731910_-|Argininosuccinate-lyase
MSRKFLSALRNAGMCGAMMLGGLSAAPAAAADAWPGQPIRMVVPFAPGGAVDTLGRLVAKQLTDVLGQTVVVENKPGAGGNIGSNIVAKAAPDGYTLLFGAAGNITINPSLFDNMPYDVEKDLAPAALAGQSMNVLVVPAALPVDSVAELIDYARKHPDKLNYGSSGNGGTTHLAGELFNAMAGTRITHVPYQGSGPAMIDLLAGRVQLMFDNLPSAMPHIQRGDLKALGVTGAMRSPQLPDVPTIAETGLAGFEATTWFGVFAPAGTPQAVLERLNGAVNQVMQSAPVEQKLQSMAAYFQPTTRAQFQTLIHDDTAKWARVIKAAGIKLN
>LR134326.1|VEF44377.1|3729498_3730884_+|2-methylcitrate-dehydratase
MNPALPATPSDRFAAGLAEVCQFVSTLSWDAIPDAVRQRAVDVLCDDLAAMAAAAPEPELRRYAALLTARAGTAESPLLSPALPRVGRMEAASWNALAGNWCELDEGFRLAICHAGIYTLPALLAEATATRARLRDVLTALTGAYELVTRCAMSFHVMPPPVHGHALWSAVGAAAAVSLLRGHDAQTLLRAVSGAITTASMGPRSHLMAGVLIRNGWAAAGAVNGMQCADWAECGFGGAPASMEEVCAGIVKASLREGEITRELGTRWSLSHGYQKLYSCCQHGHSAVQACLALRADPGFEPQRIRAIRLDTHALALTLDTVHPTTTLGARFSMPHMVAAALALGTGSAAAFSQSTLSDPAVAALREKVRMRLADAPMPAPHDRPAWLEVELDDGQVLRASCLSATGSPDNPVTPAQFEDKLARLGADVLPRLPQAIAPAAWQAALDEETGAWLAALARQA
>LR134326.1|VEF44397.1|3743505_3744096_-|HTH-type-transcriptional-repressor-nemR
MDTPSTNTTRDQLLDYAQKLIRTRGCNGFSYRDLADHVGVKTSSVHYYFPCKDDLLYEAVENYTGSALETLRGISPTLPAKERLDAYIAMVESHSCQADQLCLGGMLAAELNTLPERVRAALQAFFTVEENWLAKVLADGAREGTLRYASTPEKAARALFATVQGCLLGARLFQRPPDLREALGALYVQCGASPAH
>LR134326.1|VEF44399.1|3744221_3744527_-|Uncharacterised-protein
MNRIATALILSASVFGVAQAGELDYPPAIESANTLSHAQVQAELQAARTQGLMAAGEQDYPITAYAAASTVSREQVRDELAAARAQGLTESGELAYPPVAG
>LR134326.1|VEF44401.1|3744590_3744896_-|Uncharacterised-protein
MNRIATALILSASVFGVAQAGELDYPPAIESASALSHAQVQDELLAARAAGQMNSAELAYPPVVEQAATQVSRSQIRQELSAAKARGLDASGELDYPPVAG
>LR134326.1|VEF44402.1|3745364_3746372_+|Biotin-synthase
MHTAYIPVPTPVRPPSAERWPLAAVAELFELPFLDLLHRAQQVHRQHFDANTVQLSSLLSIKTGGCPEDCAYCPQSAHYDTGVDADKLMPLDEVVRAARAAQANGAQRFCMGAAWRSPKPHHLEAVAEMIGAVKALGMETCVTLGMLRDGQAEQLKAAGLDYYNHNLDTAPEFYGKIISTRTYQDRLDTLQQVREAGINVCCGGIVGMGESRRDRAGLVAQLANMEPYPESVPINNLVQVEGTPLAGAETLDPFEFIRTIAVARITMPLAKVRLSAGRETMSDSEQALCFMAGANSIFYGDVLLTTGNPQVEADRRLLQRLGMRAEGLPCAASQA
>LR134326.1|VEF44404.1|3746368_3747244_+|EamA-like-transporter-family
MNQGLLYLAASVACSVTVAVLLKLARRHAIDVRQAIAVNYAVAAALCWLLLRPDAQALRQAMQGAPVLAALAVLLPTVFVAMARSVRHAGIVKSDAAQRLSLFIPLLAAFALFGESLTARKLAAIALAFAALACLLRRRAPAGAAADDAPDDRRAAWMWPLAVWAGYGVIDILFKQLARSGTAFSAGLLATFVAAGLLTLAYLCIRRTRWQARHALAGVALGLANFGNILTYVRAHQSLPDHPALVFGAMNMGVITAGTLVGALAFRERLSALNLAGLALALAAIAAMLPW
>LR134326.1|VEF44406.1|3747357_3748758_-|Uncharacterized-MFS-type-transporter-ycaD
MLTTISSFSSLYFATLLMLIGTGLFNTYMGLRLTAQSVNEIWIGALIAGYYLGLVCGARLGHRLIIRVGHIRAFVACAAVATSMILAQALVDHLPLWLLLRLISGIVMVTEFMVIESWLNEQTENHQRGRVFSVYMVVSGLGTVLGQLALTAYATLDDGPLTLVAMCLVLCLVPIAVTARSHPPTPLPAPLDLRFFASRVPLSLTVLFVAGNLSGAFYGLAAVYAAKHGLSTSQSAIFVAAAVTAGLLSQWPMGWLSDRINRAGLIRFNAAVLVLLPVLMWGWIVLPYWAMVALSCVFGVLQFTLYPLGAAFANDHVEPERRVGLSAILLMTYGVGACLGPLIAGVMMSLGGPGMYYVFISACAVILVWQVRPARVTGAHQVDEAPVHFVPMPDTLQSSPAAVALDPRVDPDVDITMEMADPGPDVVEPPAPAGPPAPGADSESTSAPQAGEQAAPDDTAARRTGT
>LR134326.1|VEF44408.1|3748835_3749339_-|Putative-peroxiredoxin-sll1621
MTIKVGDRVPDGTLTEFIETETAGCTLGPNAFQVADLVKGKKIALFAVPGAFTPTCSAKHLPGYVEQAAALRAKGIDEIWCVAVNDAFVMGAWGREQQAGGKVRMLADGSALWTTALGLELDLVQRGMGVRSQRYSALIDDGVVKQLNIEAPGKFEVSDAATMLAQA
>LR134326.1|VEF44410.1|3749577_3750009_+|Uncharacterised-protein
MTRHFLAALLLAAASGAACAQAGADPAGQAIFDQIVLTSGAANGAARTCGASAPDLAQHAETWRLNLRRYADEYHYAFDSFDERYARGQQEGAEMMADMRASGVDGCTGALASFQRERTMTYDEMKQAIAEATDGLPEDQPAD
>LR134326.1|VEF44412.1|3750018_3750903_-|Carboxymethylenebutenolidase
MTDADPHFDSLLPPLTLTRRGFVVTSLAAGFSLAAGAAAAQSAIHTDAAGLTAGKVDIPTPDGKMPAYRAAPAGKKDLPTLLVVSEIFGVHEYIQDVCRRLARLGYQAVAPELFARYGDPTGYTDIGRLRAEVVDKAGDRQVLADLDAAAAWAAANGGNSSRLGILGFCWGGRIVWLYAAHNPGLKAGAAWYGQLGGQASELKPRSVLESIGDLKAPVLGAYGGKDAGIPLSDVDRMRLALAKGPRAARDSRIDVYPEAPHAFHADYRPSYRKAEAEQAWQRMLDWFGQHGLAA
>LR134326.1|VEF44414.1|3750920_3754382_-|Uncharacterized-protein-involved-in-outer-membrane-biogenesis
MPVRMPGVRLTRRTVKVLLATVLVVLLLAGLAAWQVPRIVRGALTQDVSAMLGRDVSVGKIRFNPFTLTLRAHDLALAQPEGAAPLLQVAELDVSASWMSLFWFAPVVDSLVVRQPRIALVREDVTRFNFSDIQQKVADMTAQSPPEPEPEAGPPRFSLNNMVLEGGEITLDDKVSGRQQRIDEIALGVPFISTFGYATDIDVQPRVHMRINGSPFDLTGVARPFDTVPSSTLDVSFAGLELEKWADAWPLPLPVKLERALLDSDLQVLFEQPKDAAPRIKVVGELGLRQLDVRESSGDVLAQWSALAVRRIAFEPMQRSLYVGEVELWSPQIQTRRYADQRLNWLDIAQKLQKLGAGDAPAKPAAAPAPTPAPAPAPAPAPAQASASATPAAAQAAAAPQASAAAAAPDAWHVVVDAINVRDAELHLRDAVTKLDYVMNGVGATVEGLELPQPPDRPIGLWLTMDSTIDGSWLRAKGPLTLEPLNLDVKVELDRLALARLAPAVRASAPILVEDGRLGAQARVRVAQRDGATQVVAEDAALRLSDLSLRDESVKPAVPVSVKQFEARFDRLAPDAQPSPFTLKADGVQGEGALAMQGSLTAQPLALKSSVDLARLDLAPFAPYIASSLNATVRAINLSARGDAEFAAAAGATPMKAAWRGALDVNDLDLADRVNRDDFMQWKRLGLAGMQVSVNGDAFAANLGDITLDDFYGRVLLNAEGRLNVMDLVAEPGQAGGSITQDTQTRARAAAPAKPGPMPDIAIGSVTLKGGKMTFTDRFVKPNYTAELSRIEGSVSAVSSRQPKPAKVNVAGRVYTSAPFSISGTVQPFAQFLSLDLKASAKGVDLPRFTTYSAKYVGYPIKRGKLSLDVQYQIKDRALQASNRVVLNQLTFGDKTDSPDAVKLPVLLAVALLKDSRGNIDINLPISGSLDDPQFSVGGIIVRVLVNLVVKAVTSPFTLLASAFGGGEELSYIEFDPGSAALTPEAESRIETLAKALNDRPGLKLDVAGRADPASDEEGLRQAWVERQIRLAKARDTAGRGKKPAPDGVEVAPAERAKYLEEVYDDTKIEGKPRNFIGMAKSIPAEQMEALLRGAAPLGADDLRKLADARAQAVYEKLQAEGPADRIFVVAPQLDADGIKDDGKPTRVDFSLK

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Crispr_ID: LR134326_7

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134326_7

5172295-5172432

Orphan

Consensus_repeat	Method
ATGTTCCACGTGAAACAAC	PILER-CR

2 spacers

The CRISPR arrays of LR134326_7

>merge|LR134326|7|5172295-5172432|PILER-CR
ATGTTTCACGTGAAACATGCGGCGCCTGTTCCGACCCTCAATAATGCGATTACATGTTCCACGTGAAACAACACTCCTTGATTCGGCATTGAGGCAGACTCACTCAAGCCGTCAGCATGATGTTCCACGTGAAACAAC

>LR134326|7|1|5172295-5172432|PILER-CR
ATGTTTCACGTGAAACATG	CGGCGCCTGTTCCGACCCTCAATAATGCGATTAC
ATGTTCCACGTGAAACAAC	ACTCCTTGATTCGGCATTGAGGCAGACTCACTCAAGCCGTCAGCATG
ATGTTCCACGTGAAACAAC

Protein	Signature genes	Signature genes Name	Protein_function
LR134326.1\|VEF46004.1\|5167934_5168741_-\|ribosomal-protein-alanine-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
LR134326.1\|VEF46010.1\|5177308_5177746_-\|Tripartite-tricarboxylate-transporter-TctB-family	unknown	unknown	gnl\|CDD\|377815
LR134326.1\|VEF46014.1\|5181663_5182938_+\|Major-Facilitator-Superfamily	unknown	unknown	gnl\|CDD\|340913
LR134326.1\|VEF46000.1\|5163574_5163856_-\|Preprotein-translocase-subunit-SecE	unknown	unknown	gnl\|CDD\|235587
LR134326.1\|VEF46006.1\|5169541_5170234_-\|Ribosomal-RNA-small-subunit-methyltransferase-G	unknown	unknown	gnl\|CDD\|234637
LR134326.1\|VEF46012.1\|5178975_5180439_-\|Sensor-protein-qseC	unknown	unknown	gnl\|CDD\|182388
LR134326.1\|VEF46013.1\|5180425_5181106_-\|Transcriptional-regulatory-protein-BasR	unknown	unknown	gnl\|CDD\|185376
LR134326.1\|VEF46001.1\|5164193_5165384_-\|Elongation-factor-Tu	unknown	unknown	gnl\|CDD\|234596
LR134326.1\|VEF46009.1\|5175788_5177312_-\|Tripartite-tricarboxylate-transporter-TctA-family	unknown	unknown	gnl\|CDD\|225870
LR134326.1\|VEF46016.1\|5184351_5185938_+\|Glutathione-binding-protein-gsiB-precursor	unknown	unknown	gnl\|CDD\|173863
LR134326.1\|VEF46015.1\|5182882_5184235_-\|tRNA-modification-GTPase-MnmE	unknown	unknown	gnl\|CDD\|235392
LR134326.1\|VEF46005.1\|5168747_5169545_-\|Sporulation-initiation-inhibitor-protein-soj	unknown	unknown	gnl\|CDD\|379293
LR134326.1\|VEF45998.1\|5162536_5162968_-\|50S-ribosomal-protein-L11	unknown	unknown	gnl\|CDD\|234661
LR134326.1\|VEF46008.1\|5174546_5175713_+\|Methionine-aminotransferase	unknown	unknown	gnl\|CDD\|181642
LR134326.1\|VEF46003.1\|5166973_5167891_-\|Probable-chromosome-partitioning-protein-parB	unknown	unknown	gnl\|CDD\|275105
LR134326.1\|VEF46002.1\|5165979_5166981_-\|Probable-L-asparaginase	unknown	unknown	gnl\|CDD\|199208
LR134326.1\|VEF46011.1\|5177850_5178855_-\|Tripartite-tricarboxylate-transporter-family-receptor	unknown	unknown	gnl\|CDD\|225722
LR134326.1\|VEF46017.1\|5185957_5186932_+\|Glutathione-transport-system-permease-protein-gsiC	unknown	unknown	gnl\|CDD\|223674
LR134326.1\|VEF46007.1\|5170230_5172150_-\|Glucose-inhibited-division-protein-A	unknown	unknown	gnl\|CDD\|235362
LR134326.1\|VEF45999.1\|5163031_5163565_-\|Transcription-antitermination-protein-nusG	unknown	unknown	gnl\|CDD\|180161

Protein	Function_ID	Function_description	E-value
LR134326.1\|VEF46004.1\|5167934_5168741_-\|ribosomal-protein-alanine-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	2.81187e-10
LR134326.1\|VEF46010.1\|5177308_5177746_-\|Tripartite-tricarboxylate-transporter-TctB-family	gnl\|CDD\|377815	pfam07331, TctB, Tripartite tricarboxylate transporter TctB family. This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	2.97032e-07
LR134326.1\|VEF46014.1\|5181663_5182938_+\|Major-Facilitator-Superfamily	gnl\|CDD\|340913	cd17355, MFS_YcxA_like, MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters. This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	6.81521e-33
LR134326.1\|VEF46000.1\|5163574_5163856_-\|Preprotein-translocase-subunit-SecE	gnl\|CDD\|235587	PRK05740, secE, preprotein translocase subunit SecE; Reviewed.	1.14356e-31
LR134326.1\|VEF46006.1\|5169541_5170234_-\|Ribosomal-RNA-small-subunit-methyltransferase-G	gnl\|CDD\|234637	PRK00107, gidB, 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG.	1.9819e-75
LR134326.1\|VEF46012.1\|5178975_5180439_-\|Sensor-protein-qseC	gnl\|CDD\|182388	PRK10337, PRK10337, sensor protein QseC; Provisional.	9.98232e-53
LR134326.1\|VEF46013.1\|5180425_5181106_-\|Transcriptional-regulatory-protein-BasR	gnl\|CDD\|185376	PRK15479, PRK15479, transcriptional regulator TctD.	2.3231e-75
LR134326.1\|VEF46001.1\|5164193_5165384_-\|Elongation-factor-Tu	gnl\|CDD\|234596	PRK00049, PRK00049, elongation factor Tu; Reviewed.	0
LR134326.1\|VEF46009.1\|5175788_5177312_-\|Tripartite-tricarboxylate-transporter-TctA-family	gnl\|CDD\|225870	COG3333, COG3333, Uncharacterized protein conserved in bacteria [Function unknown].	0
LR134326.1\|VEF46016.1\|5184351_5185938_+\|Glutathione-binding-protein-gsiB-precursor	gnl\|CDD\|173863	cd08498, PBP2_NikA_DppA_OppA_like_2, The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold. This CD represents the substrate-binding domain of an uncharacterized ATP-binding cassette (ABC) type nickel/dipeptide/oligopeptide-like transporter. The oligopeptide-binding protein OppA and the dipeptide-binding protein DppA show significant sequence similarity to NikA, the initial nickel receptor. The DppA binds dipeptides and some tripeptides and is involved in chemotaxis toward dipeptides, whereas the OppA binds peptides of a wide range of lengths (2-35 amino acid residues) and plays a role in recycling of cell wall peptides, which precludes any involvement in chemotaxis. Most of other periplasmic binding proteins are comprised of only two globular subdomains corresponding to domains I and III of the dipeptide/oligopeptide binding proteins. The structural topology of these domains is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the ligand-binding domains from ionotropic glutamate receptors, LysR-type transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	0
LR134326.1\|VEF46015.1\|5182882_5184235_-\|tRNA-modification-GTPase-MnmE	gnl\|CDD\|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
LR134326.1\|VEF46005.1\|5168747_5169545_-\|Sporulation-initiation-inhibitor-protein-soj	gnl\|CDD\|379293	pfam13614, AAA_31, AAA domain. This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	1.37402e-85
LR134326.1\|VEF45998.1\|5162536_5162968_-\|50S-ribosomal-protein-L11	gnl\|CDD\|234661	PRK00140, rplK, 50S ribosomal protein L11; Validated.	3.95413e-93
LR134326.1\|VEF46008.1\|5174546_5175713_+\|Methionine-aminotransferase	gnl\|CDD\|181642	PRK09082, PRK09082, methionine aminotransferase; Validated.	0
LR134326.1\|VEF46003.1\|5166973_5167891_-\|Probable-chromosome-partitioning-protein-parB	gnl\|CDD\|275105	TIGR04285, parB-like_partition_protein, nucleoid occlusion protein. This model describes nucleoid occlusion protein, a close homolog to ParB chromosome partitioning proteins including Spo0J in Bacillus subtilis. Its gene often is located near the gene for the Spo0J ortholog. This protein bind a specific DNA sequence and blocks cytokinesis from happening until chromosome segregation is complete.	3.93163e-80
LR134326.1\|VEF46002.1\|5165979_5166981_-\|Probable-L-asparaginase	gnl\|CDD\|199208	cd08964, L-asparaginase_II, Type II (periplasmic) bacterial L-asparaginase. Asparaginases (amidohydrolases, E.C. 3.5.1.1) are enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases. This model represents type II L-asparaginases, which tend to be highly specific for asparagine and localized to the periplasm. They are potent antileukemic agents and have been used in the treatment of acute lymphoblastic leukemia (ALL), but not without severe side effects. Tumor cells appear to have a heightened dependence on exogenous L-aspartate, and depleting their surroundings of L-aspartate may starve cancerous ALL cells. Type II L-asparaginase acts as a tetramer, which is actually a dimer of two tightly bound dimers. A conserved threonine residue is thought to supply the nucleophile hydroxy-group that attacks the amide bond. Many bacterial L-asparaginases have both L-asparagine and L-glutamine hydrolysis activities, to a different degree, and some of them are annotated as asparaginase/glutaminase.	2.58004e-128
LR134326.1\|VEF46011.1\|5177850_5178855_-\|Tripartite-tricarboxylate-transporter-family-receptor	gnl\|CDD\|225722	COG3181, COG3181, Uncharacterized protein conserved in bacteria [Function unknown].	3.55463e-94
LR134326.1\|VEF46017.1\|5185957_5186932_+\|Glutathione-transport-system-permease-protein-gsiC	gnl\|CDD\|223674	COG0601, DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism].	2.98362e-117
LR134326.1\|VEF46007.1\|5170230_5172150_-\|Glucose-inhibited-division-protein-A	gnl\|CDD\|235362	PRK05192, PRK05192, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG.	0
LR134326.1\|VEF45999.1\|5163031_5163565_-\|Transcription-antitermination-protein-nusG	gnl\|CDD\|180161	PRK05609, nusG, transcription antitermination protein NusG; Validated.	1.04532e-103

>LR134326.1|VEF46007.1|5170230_5172150_-|Glucose-inhibited-division-protein-A
MDFPREFDVIVVGGGHAGTEAALAAARAGAQTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDALGGAMAIATDEAGIQFRILNSSKGPAVRATRAQADRVLYRNAIRARLENQPNLWLFQQAVDDLMVQGDQVVGAVTQIGLRFRARTVVLTAGTFLNGLIHVGLQNYSGGRAGDPPANSLGQRLKELQLPQGRLKTGTPPRIDGRSINYSVLEEQPGDLDPVPVFSFLGKASMHPRQLPCWITHTNARTHEIIRGGLDRSPMYSGVIEGVGPRYCPSIEDKIHRFADKASHQVFLEPEGLNTHEIYPNGVSTSLPFDVQYELIHSLPGLENAHILRPGYAIEYDYFDPRALKSTLETKAISGLFFAGQINGTTGYEEAAAQGLLAGANAALQAQGKEPWVPRRDEAYLGVLVDDLVTRGVTEPYRMFTSRAEYRLSLREDNADLRLTEIGRRLGLVDDVRWDAFSRKRDAVAQEVERLKSTWVNPRVLPAHAAEALLGKAIEREYSLSDLLKRPNVSYEALMQARTDEGELLAGPGVLEDDVLAEQVETQVKYAGYIARQQDEVQKHLSHEQQPIPADIDYDAVTSLSFEVRQKLKTHRPETIGQAARVSGVTPAAISLLLIHLKRLHYGSRKQAA
>LR134326.1|VEF46006.1|5169541_5170234_-|Ribosomal-RNA-small-subunit-methyltransferase-G
MSAVPDIPGGPAQRLAQACDALRLPADAGQQQKLLRYIEQMQRWNRTYNLTAIRDPGQMLVQHLFDSLSVVAPLERGLPAAGSGARVKLFDVGSGGGLPGVVLAIMRAHWDVTCVDAVEKKTAFVRQMAGALGLPNLQAAHTRIEQLEPAQCDVVISRAFASLQDFAKLAGRHVREGGTLVAMKGKVPDDEIQALQQHGHWTVERIEPLVVPALDAQRCLIWMRRSQGNI
>LR134326.1|VEF46005.1|5168747_5169545_-|Sporulation-initiation-inhibitor-protein-soj
MKNIPPSKSARVFCIANQKGGVGKTTTAINLAAGLATHKQRVLLVDLDPQGNATMGSGIDKSTLESNLYQVLIGEAGIEQTRVRSESGGYDVLPANRELSGAEIDLVQMDERERQLKAAIDKIAGEYDFVLIDCPPTLSLLTLNGLAAAHGVIIPMQCEYFALEGLSDLVNTIKRVHRNINNELRVIGLLRVMFDPRMTLQQQVSAQLESHFGDKVFTTVVPRNVRLAEAPSYGMPGVVYDRASRGAQAYIAFGAEMIERVKELD
>LR134326.1|VEF46004.1|5167934_5168741_-|ribosomal-protein-alanine-N-acetyltransferase
MPAVLAVPAAHPAPAAGGELARLEEAALNATTVREQMLYEGWLVRWAPSRAKRARCVNVLGLSTRPLDERLAYCTRWYAGHGVPLIVRLTSIGPDFSLDAQLHERGFVAFDRTCVMAAPVVPFTAQAPSGLVFERTTPGRFAQEAGRLRGHDDAATAEHAARLQAAPLENLPLLVRDASGECIAAGLAAFDAELVGLFDIVTAPQRRRQGCGAAVLKYLLEQASHAGARQAYLQVEPQNTAARALYARFGFVDRYTYWYRSMSEATPV
>LR134326.1|VEF46003.1|5166973_5167891_-|Probable-chromosome-partitioning-protein-parB
MATKKPKGLGRGLDALLGADVPAIDNIGKAPAAAPEGPPATLPVSKMRAGKYQPRTRMDEGALNELAESIRTQGIMQPILVRALGADAPGQYEIIAGERRFRAAQLAGLKEVPVLVREVADENAAVMALIENIQREDLNPLEEAHGVRRLLDEFGLTHEQAAQAIGRSRSATSNLLRLLNLAAPVQTMLLAGDVDMGHARALLAVDAATQIQLANQVIAKRLSVREAEKLVARAQKDVDAAPRKKGNGASRDVTRLEEALSDHLGTRVALKVGAREKGQIVIDFHGWEHLNSLLERQGLSGVVDA
>LR134326.1|VEF46002.1|5165979_5166981_-|Probable-L-asparaginase
MPEARLPRIAVLATGGTIAGAQTDAASGAYRAGSYGVGQLLAAVPQLAGLARIGAEQIANVGSQNMSHAVWRQLALRAAALCDDPATDGIVITHGTDTLEETAYFLSLVLPVDKPVVLLGAMRPATALSADGPVNLYNAVALACHPAARGRGPLVVMNEDIHLARHVQKTAASGIAAFASPNAGRAGVMQGGRPVFHARAERQAADALLRPDELPQQAWPRVDIVHACVDLDGELIDFMAGRAQGIVLAGVGDGNATDAALQALQRASARGVAVVRASRTGSGRVGRNIEIDDDACGFIAAGDLSPQKARVLLTLGLCQTRDTARLQALFDSR
>LR134326.1|VEF46001.1|5164193_5165384_-|Elongation-factor-Tu
MAKGKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLSNKFGGEARGYDQIDAAPEEKARGITINTSHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLSRQVGVPYIIVFLNKADMVDDAELLELVEMEVRELLSKYDFPGDDTPIVKGSAKLALEGDKGELGEQAILSLAQALDTYIPTPERAVDGAFLMPVEDVFSISGRGTVVTGRIERGVVKVGEEIEIVGIKPTVKTTCTGVEMFRKLLDQGQAGDNVGILLRGTKREDVERGQVLAKPGSINPHTDFTAEVYILSKEEGGRHTPFFNGYRPQFYFRTTDVTGTIDLPADKEMVLPGDNVSMTVKLLAPIAMEEGLRFAIREGGRTVGAGVVAKIIK
>LR134326.1|VEF46000.1|5163574_5163856_-|Preprotein-translocase-subunit-SecE
MLDAQPMVARIGVFVGGLVVAALLAWFSEPGRRTLSFAGESYNEVKRVSWPTRKETIQMTGIVFAFVAVMGLLMWVLDKGIEWVLYGLLLGWK
>LR134326.1|VEF45999.1|5163031_5163565_-|Transcription-antitermination-protein-nusG
MSKRWYVVHVYSGMEKSVQKALNERIERAELQTSFGRILVPSEEVVEVKGGQKSITERRIFPGYVLVEMDLTDETWHLVKNTNRVTGFLGGSGNRPTPISEREVEKILNQMEEGVEKPRPKILFEVGEMVRVKEGPFADFNGNVEEVNYEKSKVRVSVTIFGRATPVELDFSQVEKT
>LR134326.1|VEF45998.1|5162536_5162968_-|50S-ribosomal-protein-L11
MAKKIVGFIKLQVPAGKANPSPPIGPALGQRGLNIMEFCKAFNAKTQGMEPGLPIPVVITAFADKSFTFIMKTPPATVLIKKASGVQKGSAKPHTDKVGTLTRAQAEEIAKTKQPDLTAADLDAAVRTIAGSARSMGITVEGV
>LR134326.1|VEF46008.1|5174546_5175713_+|Methionine-aminotransferase
MIRSKLPDVGTTIFTVMSRLAIEHKAINLGQGFPDFDPDPELCALVGKAMAAGHNQYPYMPGVAPLREAIAAKVKTLYGHAYDPETEITVTSGATEALMATVLAAVGPGDEVVVIEPCYDSYLPAIRLAGGTAVPVPLRAPTRDDPYYRIDWQRVRDAIGARTRLLMLNFPHNPTGAVLDESDLDALESIVRETGVLLLSDEVYEHIVFDGKPHASLSRRPLLAEHAFVISSFGKTYHTTGWKVGYCCAPRQLSAELRKVHQFMVFTVSSPMQFALAEYMANPKPYLDLPAFYQAKRDRLAAGLANTRFRPLPSPGTFFMLADYSEITKHAEADFARHLTIDHGVTVIPVSAFYQNPAAPESNHHLVRFCFAKQDATLDAAIERLAHV
>LR134326.1|VEF46009.1|5175788_5177312_-|Tripartite-tricarboxylate-transporter-TctA-family
MSGILDHLAIGFGVAFSLTNVLVAAIGSFFGTMVGVLPGLGPINGVAMLIPIAFAMNLPPETALILLAAVYVGAEYGGRITSILLNVPGEASAIMTTLDGYPLARQGLANVALSLSAWSAFFGAIVSVTGIILLAPLLAKWALAFGPAEYFVLMVFAFCCLTSLLGKQPVKGVLAAMIGLGISVVGVDSNSGVYRYTFDSVHLSDGIDFVVVVIALFAVSEMLEMLEKVVAGHSIEVKPSGRKLFNLKELSFTWWSVVRSSLVGFGVGVLPGAGASVAAAVAYSQEKRIIESKDPDAKFGKGDMRGLVAPESAATASAIGSFVPMLTLGVPGSGTTAVMMGALTLYNITPGPVLFDSKPELVWGLIASLFIANVLLFIMNVPMVRVFSKVLAVPAWMMVPGILCISYIGVYAINAGTFDLLMVVAIGALGYFLRKFGVPMAPLVLGVVLGDMMEQNLRRALSITNGDPVVLYSSPVSIGLWIAAAAVVIVPQLMRRLSARRRQAAQS
>LR134326.1|VEF46010.1|5177308_5177746_-|Tripartite-tricarboxylate-transporter-TctB-family
MNDRMLGVFALILAAFMTWAGWDIEAPFAYEPVGPRAFPMLVALIIGLCGLRLVYKGGHQVETNSAGANARIALMVAYAAAYAFLFQWLGFVIATALMTVAVGRLFGGNWIKCAIGGLIMGVLFFLLFDKVLDVVLPAGLLEGLL
>LR134326.1|VEF46011.1|5177850_5178855_-|Tripartite-tricarboxylate-transporter-family-receptor
MHTLAKFRATAAALAGLCALFIGNAAHAASDEPRRPECIAPAQPGGGFDLTCRLATEGLKQSGALKAPMRIVYMPGGIGAVAYNNIVAQHPGEAGTIVAFSGGSLLNLAQGKFGKYSVDDVRWLAGIGADYGVAVVRNDSPYTDLKGLMEAFKQDPTKIVLGAGGTVGSQDWMKAALTAKAAGVDFKKMRFVAFEGGGEAVTALRGGHIQAYMGDAAEAFTMLEGGAPIRVLAVFNSERLPGKLNNVPTAKEQGYDIVWPIIRGFYVGPKVSDKDYQFWVDAFDKTMTSPEYAKLREQQGLFPFSKTGKDLDDYVKQQVKNYAELADSFGLIKK
>LR134326.1|VEF46012.1|5178975_5180439_-|Sensor-protein-qseC
MTTRRQEKTRHRTLKTVLLWWLIPALVFVMTGALWLSNQQLRNQVDIAYDRSLSGALRSIDHNISTASGGLSLEQPYLMLEFFELTANGNVYYRVATEDGLAEIGNPQLPLPPQPLVSGQPQFFYAEYLGQPVRVAALARPMDPPLYNDKGGRIIVQVAESLETRQDFLHRALVRSVERDLAVVMISVLVVIWSVFMALRPLERLREEVASRSADDLSPVSASEMPGEVQPLIHAVNLHMARFTALARVQRQFLDDASHQLRTPLSVLRTQTAYALRETDPQEVRTALLAMQDGLDRAVRTTNQMLALARAKDASLAEGGLPLETVDLAELADGVIRALLPAARARQLDLGLDVQAAPVRVQAVEWLLREALSNLVDNAIRYTARGSEVTVKVHAEGGHAWLVVEDNGPGMSAEDIARASVRFRRGAAGKNKSGAGLGLAIVRTIIEIHGGQLVLENRQPQPGLRAALVFSLGFKGNAALPHEIVVI
>LR134326.1|VEF46013.1|5180425_5181106_-|Transcriptional-regulatory-protein-BasR
MRILLIEDEAELARWLSRSLARHAGFVVEWADDGLLAERRLAVEEFDAIILDLGLPGMDGHTLLTRIRARDDRTPVLVLTARDSLAERVGTLHQGADDFLPKPFVLEELEARLTALIRRSRGREHPRLTLGDLALDTASQRFTVKGQPLALSPREHAVLRALIQRSGEPLNKQQILDRIQSSDSDVNLEAIEVLVHRLRKKLADTGVQIVTMRGMGYCLENAVDNP
>LR134326.1|VEF46014.1|5181663_5182938_+|Major-Facilitator-Superfamily
MTRHSTPFAGRQVLAASFVMAIYGWGMGFYGPPVFLHAVVERTGWPLQWVAGMVTLHFVAGALAVANLRRLYRLAGIPMVTFCGALGSALGTFGWAVAATPWQLAIAALVSGASWAALGAAAINALIEPWFVVRRPAALGMAYNGASVGGIVFSPLWALLIQARGFAWAAGVVGASMVLVIAVLASLVFTRTPANTGQAPDGEAVAPRPAANPAPPARPAGRLREDRRFVTLAAAMSLGLFAQMGLVAHLYSLLVPTLGPGTAGLAMGAATGCAIAGRTIVGRIAGAGSDRRLLASHAYAIQALGALLLLAAGDTPALVWLGLLLFGSGIGNATSLPPLIAQNEFDPASVRRVVPLIVALSQAAYAFAPAVFGMLRGVSDAASAPWLFVAAAALQAAAIACLLAGRATCRCRNSKRSRPASRRW
>LR134326.1|VEF46015.1|5182882_5184235_-|tRNA-modification-GTPase-MnmE
MSLYAPIAAIATAPGRGGIGVVRISGPDLAELAQRLFGRPLTPRHAHYLPFRAADGEVIDEGLAIYFRAPHSYTGEDVLELQGHGGPAVLRRILARCLQAGHDLGLRPAEPGEFTRRAFLNERLDLAQAEAVADLIDASSEAAARGAMASLSGEFSQRVNDLSDRIIHLRMLVEATLDFPEEEIDFLEKYQARPTLQALTHDLDTLIAQARQGVILREGLHVVLAGKPNVGKSSLLNALAGDDIAIVTPIAGTTRDKVVQEIHIDGVPLHIVDTAGLRDTDDAVESIGIERTWKEIERADLILHLQDVTQPPDHLDAQIVRRLPARTPVLNVFNKVDLLDAAFQGRPDSLAISARGGIGLDALRQRLLQLAGWNPGAESPWLARERHLHALQQAAQHLEIATEHAREDDRVLDLFAEELRLAHEALTGITGKFTSDDLLGEIFSSFCIGK
>LR134326.1|VEF46016.1|5184351_5185938_+|Glutathione-binding-protein-gsiB-precursor
MISRLSRVVTCGSVIVALALGGASAALARDLVVALKTEPSSMDPQYHALTPNTQISQTIFDPIVRVDEQLKPQPALAESWTVDGKVWTFKLRPDVKFSDGTPFTAEDVVFTYDRIPKVPNSPSPFTLYLGAVAKTEAVDPLTVRITTKDVTPLLLVNLAQLPIMSKKAASGPAPEGKTTTELNSGNGLIGTGPYKFVSWKRGAEFVLARNENYWGKPPAWDKVTYRPMTNAAARVAALLAGDVDMIEDPPTDDLPKLKADKKLYVEETPSVRVVYLALDQYAEPSPGVQGTDKNPMKDKRVREALSLALNRDAIVDRVMGGVAKPAGNLLPYPMFGSSKEHSQAPKADVEKAKALLKEAGYPNGFSITLGSPSGRYVNDAKVAQAIASMWTRIGVKTSVDSMAPPVFFKNRDSYAFSAYLAGWSVTSGEMSNALTSLLVTRNPEAGLGTTNRSRYSNPAMDELVKQASSTMDDAKRAELLQKASNLAMDDYAMLPVHFELSVWAMKNDIRYTGRPDQTTLVQYATVKK
>LR134326.1|VEF46017.1|5185957_5186932_+|Glutathione-transport-system-permease-protein-gsiC
MLATIIRRLLQTVVVMLVMSALVFAGIYMVGDPVSMLASPEATEAQRTAIRVSLGLDQPLWKQYLIFMGQAVRGDFGNSFLTGEPAMRLILERMPATLELACVAMLLSVLIGVPLGIRAGLKPKAPASRVIMTGSVLGFSLPNFWVGLMLIMIFAVTLGWLPASGRGQTVSVAGLSLSVLTLDGWASLILPAATIALAKCAMIIRVTRAATRESLPQDYIKFARAKGLPEKRVLGVHLLKNILIPIVTVAGLEFGQVVAFAVVTETVFSWPGMGKLLIDSIINLDRPVVVAYLLLIVFFLVMLNLVVDIIYTVLDPRVRLDSRQ

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
LR134326_6	6.1\|3743337\|19\|LR134326\|CRISPRCasFinder	3743337-3743355	19	LR134326.1	1599198-1599216	0	1.0
LR134326_6	6.1\|3743337\|19\|LR134326\|CRISPRCasFinder	3743337-3743355	19	LR134326.1	3728639-3728657	0	1.0

1. spacer 6.1|3743337|19|LR134326|CRISPRCasFinder matches to position: 1599198-1599216, mismatch: 0, identity: 1.0

gcacccgcaaactctcggg	CRISPR spacer
gcacccgcaaactctcggg	Protospacer
*******************

2. spacer 6.1|3743337|19|LR134326|CRISPRCasFinder matches to position: 3728639-3728657, mismatch: 0, identity: 1.0

gcacccgcaaactctcggg	CRISPR spacer
gcacccgcaaactctcggg	Protospacer
*******************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

2837583 : 2845643

uncultured_Mediterranean_phage(28.57%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VEF42752.1\|2837583_2838465_-	Murein hydrolase activator NlpD precursor	A0A292GJG6	Xanthomonas_phage	4.6e-15	49.5
VEF42754.1\|2838482_2839262_-	Protein-L-isoaspartate O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	4.8e-32	46.9
VEF42756.1\|2839246_2840005_-	5'-nucleotidase surE	A0A1B1ITZ2	uncultured_Mediterranean_phage	6.2e-69	51.2
VEF42758.1\|2840142_2840778_+	G3P acyltransferase	NA	NA	NA	NA
VEF42760.1\|2840822_2841863_-	t(6)A37 threonylcarbamoyladenosine biosynthesis protein	A0A0R6PI74	Moraxella_phage	9.3e-92	51.6
VEF42762.1\|2841997_2843290_+	Probable adenine permease PurP	A0A0R6PHV4	Moraxella_phage	1.7e-66	36.0
VEF42764.1\|2843495_2844521_+	Alkanal monooxygenase alpha chain	NA	NA	NA	NA
VEF42766.1\|2844656_2845040_+	Thioredoxin-2	V9SJ74	Achromobacter_phage	8.1e-09	25.8
VEF42768.1\|2845058_2845643_-	IMPACT family member yigZ	A0A1X9I5T8	Streptococcus_phage	2.1e-16	46.8

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. LR134326

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CRISPR-Cas detection and classification

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection