CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
LR134361	Achromobacter insolitus strain NCTC13520 genome assembly, chromosome: 1	5 crisprs	WYL,csa3,DEDDh,DinG,PD-DExK	0	0	2	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: LR134361_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134361_1

213737-213886

Orphan

Consensus_repeat	Method
CCCCACGCTGCGCAAGCTTTGCTTGCTTGCTGCCCCCCGAGGGGG	CRISPRCasFinder

1 spacers

The CRISPR arrays of LR134361_1

>merge|LR134361|1|213737-213886|CRISPRCasFinder
CCCCACGCTGCGCAAGCTTTGCTTGCTTGCTGCCCCCCGAGGGGGCTGGCCCGCCTTGGGGCGGCCCGGCGGCGGGCCGGCTATTTTTGCGGAGGCTGTGTTGGTCCCCACGCTGCGCAAGCTTTGCTTGCTTGCTGCCCCCCGAGGGGG

>LR134361|1|1|213737-213886|CRISPRCasFinder
CCCCACGCTGCGCAAGCTTTGCTTGCTTGCTGCCCCCCGAGGGGG	CTGGCCCGCCTTGGGGCGGCCCGGCGGCGGGCCGGCTATTTTTGCGGAGGCTGTGTTGGT
CCCCACGCTGCGCAAGCTTTGCTTGCTTGCTGCCCCCCGAGGGGG

Protein	Signature genes	Signature genes Name	Protein_function
LR134361.1\|VEG65671.1\|210758_211625_+\|S-formylglutathione-hydrolase-yeiG	unknown	unknown	gnl\|CDD\|131868
LR134361.1\|VEG65668.1\|203199_204666_-\|Glutamate-synthase-[NADPH]-small-chain	unknown	unknown	gnl\|CDD\|237213
LR134361.1\|VEG65669.1\|204674_209414_-\|Ferredoxin-dependent-glutamate-synthase-1	unknown	unknown	gnl\|CDD\|236968
LR134361.1\|VEG65665.1\|200128_201373_-\|Arabinose-efflux-permease	unknown	unknown	gnl\|CDD\|340869
LR134361.1\|VEG65676.1\|217620_218433_-\|Isopentenyl-diphosphate-Delta-isomerase	unknown	unknown	gnl\|CDD\|239648
LR134361.1\|VEG65677.1\|218722_219880_+\|Cytochrome-c-oxidase-subunit-2-precursor	unknown	unknown	gnl\|CDD\|224537
LR134361.1\|VEG65682.1\|223001_223202_-\|Protein-of-uncharacterised-function-(DUF2909)	unknown	unknown	gnl\|CDD\|378564
LR134361.1\|VEG65670.1\|209761_210526_-\|Transposase-and-inactivated-derivatives	unknown	unknown	unknown
LR134361.1\|VEG65680.1\|221758_221983_+\|Protein-of-uncharacterised-function-(DUF2970)	unknown	unknown	gnl\|CDD\|378581
LR134361.1\|VEG65666.1\|201438_202311_+\|HTH-type-transcriptional-regulator-gltR	unknown	unknown	gnl\|CDD\|176133
LR134361.1\|VEG65681.1\|222021_222897_+\|Cytochrome-c-oxidase-subunit-3	unknown	unknown	gnl\|CDD\|238834
LR134361.1\|VEG65672.1\|211721_212411_+\|Uncharacterised-protein	unknown	unknown	unknown
LR134361.1\|VEG65683.1\|223241_224048_+\|Uncharacterized-conserved-protein	unknown	unknown	gnl\|CDD\|119401
LR134361.1\|VEG65664.1\|199135_200113_-\|Argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|270296
LR134361.1\|VEG65667.1\|202350_202989_-\|Outer-membrane-protein-W-precursor	unknown	unknown	gnl\|CDD\|182867
LR134361.1\|VEG65675.1\|214933_217624_+\|Sodium,-potassium,-lithium-and-rubidium/H(+)-antiporter	unknown	unknown	gnl\|CDD\|223104
LR134361.1\|VEG65674.1\|213909_214749_-\|3',5'-cyclic-adenosine-monophosphate-phosphodiesterase-CpdA	unknown	unknown	gnl\|CDD\|277347
LR134361.1\|VEG65673.1\|212579_213464_+\|Heat-shock-regulatory-protein-F33.4	unknown	unknown	gnl\|CDD\|235838
LR134361.1\|VEG65678.1\|219984_221592_+\|Cytochrome-c-oxidase-subunit-1-beta	unknown	unknown	gnl\|CDD\|238833
LR134361.1\|VEG65679.1\|221623_221749_+\|Uncharacterised-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
LR134361.1\|VEG65671.1\|210758_211625_+\|S-formylglutathione-hydrolase-yeiG	gnl\|CDD\|131868	TIGR02821, S-formylglutathione_hydrolase, S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well. [Cellular processes, Detoxification].	1.16677e-158
LR134361.1\|VEG65668.1\|203199_204666_-\|Glutamate-synthase-[NADPH]-small-chain	gnl\|CDD\|237213	PRK12810, gltD, glutamate synthase subunit beta; Reviewed.	0
LR134361.1\|VEG65669.1\|204674_209414_-\|Ferredoxin-dependent-glutamate-synthase-1	gnl\|CDD\|236968	PRK11750, gltB, glutamate synthase subunit alpha; Provisional.	0
LR134361.1\|VEG65665.1\|200128_201373_-\|Arabinose-efflux-permease	gnl\|CDD\|340869	cd06180, MFS_YjiJ, Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters. This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	1.31053e-55
LR134361.1\|VEG65676.1\|217620_218433_-\|Isopentenyl-diphosphate-Delta-isomerase	gnl\|CDD\|239648	cd03676, Nudix_hydrolase_3, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	8.54659e-65
LR134361.1\|VEG65677.1\|218722_219880_+\|Cytochrome-c-oxidase-subunit-2-precursor	gnl\|CDD\|224537	COG1622, CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion].	2.92448e-74
LR134361.1\|VEG65682.1\|223001_223202_-\|Protein-of-uncharacterised-function-(DUF2909)	gnl\|CDD\|378564	pfam11137, DUF2909, Protein of unknown function (DUF2909). This is a family of proteins conserved in Proteobacteria of unknown function.	5.90589e-17
LR134361.1\|VEG65680.1\|221758_221983_+\|Protein-of-uncharacterised-function-(DUF2970)	gnl\|CDD\|378581	pfam11174, DUF2970, Protein of unknown function (DUF2970). This short family is conserved in Proteobacteria. The function is not known.	2.7918e-20
LR134361.1\|VEG65666.1\|201438_202311_+\|HTH-type-transcriptional-regulator-gltR	gnl\|CDD\|176133	cd08442, PBP2_YofA_SoxR_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold. YofA is a LysR-like transcriptional regulator of cell growth in Bacillus subtillis. YofA controls cell viability and the formation of constrictions during cell division. YofaA positively regulates expression of the cell division gene ftsW, and thus is essential for cell viability during stationary-phase growth of Bacillus substilis. YofA shows significant homology to SoxR from Arthrobacter sp. TE1826. SoxR is a negative regulator for the sarcosine oxidase gene soxA. Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine, which is involved in the metabolism of creatine and choline. The topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis.	4.93326e-78
LR134361.1\|VEG65681.1\|222021_222897_+\|Cytochrome-c-oxidase-subunit-3	gnl\|CDD\|238834	cd01665, Cyt_c_Oxidase_III, Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. CcO catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, is believed to play a role in assembly of the multimer complex. Rhodobacter CcO subunit III stabilizes the integrity of the binuclear center in subunit I. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit III contains bound phospholipids in several crystal structures and is proposed to contain a "lipid pool." These phospholipids are believed to intrinsic constituents similar to cofactors of the enzyme.	3.2096e-93
LR134361.1\|VEG65683.1\|223241_224048_+\|Uncharacterized-conserved-protein	gnl\|CDD\|119401	cd06662, SURF1, SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring complex of the respiratory chain, is an assemblage of nuclear and mitochondrially-encoded subunits. Its assembly is mediated by nuclear encoded assembly factors, one of which is Surf1/Shy1. Mutations in human Surf1 are a major cause of Leigh syndrome, a severe neurodegenerative disorder.	9.05466e-46
LR134361.1\|VEG65664.1\|199135_200113_-\|Argininosuccinate-lyase	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	7.78288e-147
LR134361.1\|VEG65667.1\|202350_202989_-\|Outer-membrane-protein-W-precursor	gnl\|CDD\|182867	PRK10959, PRK10959, outer membrane protein W; Provisional.	9.29845e-75
LR134361.1\|VEG65675.1\|214933_217624_+\|Sodium,-potassium,-lithium-and-rubidium/H(+)-antiporter	gnl\|CDD\|223104	COG0025, NhaP, NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism].	8.50755e-66
LR134361.1\|VEG65674.1\|213909_214749_-\|3',5'-cyclic-adenosine-monophosphate-phosphodiesterase-CpdA	gnl\|CDD\|277347	cd07402, MPP_GpdQ, Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain. GpdQ (glycerophosphodiesterase Q, also known as Rv0805 in Mycobacterium tuberculosis) is a binuclear metallophosphoesterase from Enterobacter aerogenes that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. The GpdQ homolog, Rv0805, has 2',3'-cyclic nucleotide phosphodiesterase activity. GpdQ and Rv0805 belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.	3.14048e-69
LR134361.1\|VEG65673.1\|212579_213464_+\|Heat-shock-regulatory-protein-F33.4	gnl\|CDD\|235838	PRK06596, PRK06596, RNA polymerase factor sigma-32; Reviewed.	2.18193e-167
LR134361.1\|VEG65678.1\|219984_221592_+\|Cytochrome-c-oxidase-subunit-1-beta	gnl\|CDD\|238833	cd01663, Cyt_c_Oxidase_I, Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Only subunits I and II are essential for function, but subunit III, which is also conserved, may play a role in assembly or oxygen delivery to the active site. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Subunit I contains a heme-copper binuclear center (the active site where O2 is reduced to water) formed by a high-spin heme (heme a3) and a copper ion (CuB). It also contains a low-spin heme (heme a), believed to participate in the transfer of electrons to the binuclear center. For every reduction of an O2 molecule, eight protons are taken from the inside aqueous compartment and four electrons are taken from cytochrome c on the opposite side of the membrane. The four electrons and four of the protons are used in the reduction of O2; the four remaining protons are pumped across the membrane. This charge separation of four charges contributes to the electrochemical gradient used for ATP synthesis. Two proton channels, the D-pathway and K-pathway, leading to the binuclear center have been identified in subunit I. A well-defined pathway for the transfer of pumped protons beyond the binuclear center has not been identified. Electrons are transferred from cytochrome c (the electron donor) to heme a via the CuA binuclear site in subunit II, and directly from heme a to the binuclear center.	0

>LR134361.1|VEG65673.1|212579_213464_+|Heat-shock-regulatory-protein-F33.4
MKQPSTSLAAPGNALALAIANPGALGTIDAYISAVNRLPVLSAERETELGRRLRDQEDLGAARELILSHLRLVVSVARQYLGYGLPHADLIQEGNVGLMKAVKRFDPERGVRLVSFAVHWIKAEIHEYIIRNWRLVKVATTKAQRKLFFNLRSMRPDGQTLDPDQVDHIARELNVRREDVSEMEVRLSGRDMSLENQDDDDDSYAPIAYLSDEGRQEPTRVLERAARDQLQSAGLTDALEALDPRSRRIVEARWLQDDGGATLHELAQEFGVSAERIRQIEAAALKKMRGNLAS
>LR134361.1|VEG65672.1|211721_212411_+|Uncharacterised-protein
MINGIAPFVWILLGVVVVLLPGIVMLLGRGGPRDERGRRMFQFRPMRRLFGLMLVLLGCVSGLLALSLVQFFRLTTDEPVARIEVRQVADGQFQVSASAPGTGTKQYVLYGDQWQIDARVVRWRLPALMAGVPPLYRLERLSGRYSDAAREASATRSVHALDDWPAPDLASLKKNFPNWFPFVDVQFGSGAYMPLFDGARYQVLMDPRGALFIRPDGESTAEGLKRLGW
>LR134361.1|VEG65671.1|210758_211625_+|S-formylglutathione-hydrolase-yeiG
MAVALELISQHRCFGGWQRYYRHESAEIGLPMRFSVYIPPQAEQGPVPVLFYLAGLTCTEETFMIKSGAQRLAAELGVMLVAPDTSPRGANVAGEDESWDLGTGAGFYVDATTPAWRGHYRMYSYVTQELHGIVTGEALPGDASRTGIFGHSMGGHGALVLALRNPGKFRSVSAFAPIAAPSQCPWGKKAFGAYLGDKIEDWAAYDASELMRGATNPFPAGILIDQGESDQFLAEQLYPEVFEAACAAAGQPLNLRRQPGYDHGYYFISTFIEDHIRFHVERLGKPAP
>LR134361.1|VEG65670.1|209761_210526_-|Transposase-and-inactivated-derivatives
MARLPRLYAPGLPQLVQANFIQPLAAPSQPAPADILNQLATWLGESAQRHRVSVHGWLLANDRILLLATPADEEGLPRLMQTLGRNLAARLRGGRVFAGRYRSALLEPGAWVLPSLVWLETYPVRSGASQDPDSWPWSSASSHTGNTTAAPAQWQSDHADYWACGNTPFDRQANYRKRLQDGLSREETQRIDQAVSGQWALGGPAFIASLAHTASRRVAPGQRGRPRKKPAAATPADTEPNSSPPSTTPTSTSS
>LR134361.1|VEG65669.1|204674_209414_-|Ferredoxin-dependent-glutamate-synthase-1
MPQITPIDSCPPPKATPIDASRIGLPSAQGLYNPKNEHDACGVGFVAHIKGKKSHAIIQQGLKILENLDHRGAVGADKLMGDGAGILIQIPDTLYRDELGHQGITLPPPGEYGVAMVFLPKETASRLACEQELERSVRAEGQVVLGWRDVPVDVDMPMSPAVRACEPVIRQLFIGRGADVMVPDALERKLYVIRKTASHAIQNMHLAHGKEYFVPSASVRTVVYKGLLLADQVGRYYRDLADPRTVSALALVHQRFSTNTFPAWPLAHPYRMIAHNGEINTVKGNFNWLRAREGMMQSAVLGEDLKKLYPIVYEGQSDTATFDNCLELLVNSGYSLAHAMMMMIPEAWEQHTQMDESRRAFYEYHAAMMEPWDGPAAVAFTDGRQIGATLDRNGLRPARYLVTDDDMVILASEAGTLSIPENRIIKKWRLQPGKMFLIDLEQGRIIDDAEIKLQLANSRPYRQWIERLQIKLESLPAPRQAAVATQSSVSLLDRQQAFGWTQEDYKFILEPMATTGEEVIGSMGNDAPLAVLSDRAKPFYNYFRQLFAQVTNPPIDPIREQLVMSLVSFIGPKPNLLDINNVNPPLRLEVSQPVLDFAAMAQIRDIEQVTGKKFRSFELDITYPAAWGPEGIEARVAALCARAVDAVRSGYNILIVSDRLVDSERVAIPALLATSAVHQHLIRAGLRTNTGLVVETGSAREVHHFALLGGYGAEAIHPYLALESLGKMNDPEKAVKNFIKAIGKGLNKVMSKMGISTYMSYTGAQIFEAVGLQTALVNKYFTGTASNIEGIGIFQVAEEALRQHRAAFSTDPVLANDLDAGGEYAYRVRGEEHMWTPDSIAKLQHASRANNYRTYKEYAQIINDQSRRHMTLRGLFEFRFDPSRAIPLDDVEPAKEIVKRFATGAMSLGSISTEAHSVLAVAMNRIGGKSNTGEGGEDELRYRAEMREGKSTIKDGDTLASVLGSDRIEADVELKKGDSLRSKIKQVASGRFGVTAEYLSSADQIQIKMAQGAKPGEGGQLPGHKVSEYIAKLRYSVPGVGLISPPPHHDIYSIEDLAQLIHDLKNVNSKASVSVKLVSEVGVGTVAAGVAKAKADHVVIAGHDGGTGASPVSSIKHVGTPWELGLAETQQTLVLNRLRSRIRVQADGQMKTGRDVVIGALLGADEFGFATAPLVVEGCIMMRKCHLNTCPVGVATQDPVLRKKFQGKPEHVVNFFFFIAEEVREIMAQLGIRKFDDLIGRADLLDMRSGVEHWKAQGLDFARVFHQTQSDAAVRQTEEQDHGLAGALDHQLIERSKPALERGEKVSFIVPVRNRNRTIGAMLSGAVAARYGHDGLPDDTIHIQCNGTAGQSFGAFLAHGITMDLVGEGNDYVGKGLSGGRIIVRSPNDFRGFGPDHIIAGNTVLYGALAGEAFFNGVAGERFAVRNSGAATVVEGTGDHGCEYMTGGTVVVLGATGRNFAAGMSGGVAYVWDPERTLKQRANLSMVELESIVPHAEQVAQNNIDVWHSAQRGGERETDEAILRRLVEDHFRYTGSFRAREILGDWEASRGKFVKIMPTDYRRALGEMWRAANPQQLAA
>LR134361.1|VEG65668.1|203199_204666_-|Glutamate-synthase-[NADPH]-small-chain
MGKITGFMEFQRLQEASEAPQKRLKNWREFVLHLSDDQAKQQAARCMDCGIPFCNNGCPVNNIIPDWNDLVYRQDWKRALDVLHSTNNFPEFTGRICPAPCEAACTLNINSDAVGIKSIEHAIIDKGWAEGWVSPQVPARKTGKKVAVVGSGPAGLACSQQLARAGHSVTLFEKSDRIGGLLRYGIPDFKLEKHQIDRRISQMEAEGVEFAPSTYIGNPSDPVADGLTVRTPESLLAEFDAVVMSGGSETPRDLPVPGRELSGVYFAMDFLRQQNKAVAGDRLTNQTLAKGKHVVVIGGGDTGSDCVGTSNRHGAASVTQFELMPQPPESENKAMTWPYWPLKMRTSSSHEEGCERDWSVTTKLLAGSNGKVEKLVGARVEWFKDEATGQMKMREVEGSEFEIKADLVLLAMGFVSPVQTVLDAFGVDRDARGNVRANTDDYRTNVEKVFTAGDMRRGQSLVVWAIREGRQCARSVDAFLMGSSELPR
>LR134361.1|VEG65667.1|202350_202989_-|Outer-membrane-protein-W-precursor
MFSLNGRIRATAIAGLIAAGTLAAPAHAHEAGDVLFKVGVTQVRPSSNNGTVLNGSVGLDVNNNVRPSFTLTYMATRNIGIELLGAWPFQHDVSGSGLGKIGSTKQLPPTLSLQWHILPDSMIQPYIGVGINYTHFFDTKAEGALKGSDLKLGDSWGVAAQLGADFKINDRWFMNADIRYIDIRSKVKLDGQHIGTARIDPWVATLGVGYRF
>LR134361.1|VEG65666.1|201438_202311_+|HTH-type-transcriptional-regulator-gltR
MRNLDLDALQIFKAVADQGGVARAAAHLNRVQSNVSTRLKQLEASLEAPLFRRQNRRLVLSDQGRVLLSYADRLLRLADEAQAAVRDGSPQGVLRIGTMESTAAARLPPILAAYHAAWPQVRIELVTGTSAALAAKVRSYEIEAAFVAQPFPSEGLAAVDAFKEELALISPLAWDPIASPRDLGDRSVIAFASGCSYRRILESWLNQEGIAPGKVMEFASYHAIVACVAAGSGVAIVPRSVLAVLGAEHTVRVGALSGSHGRALTQLVWRADDDTPALQALRHKLQALQG
>LR134361.1|VEG65665.1|200128_201373_-|Arabinose-efflux-permease
MSTPIYPSVSHSRSAAALAWPAALALAAAMGIGRFAFTPVWPLMAQEAGLSLSEGGWLASANYAGYLLGALAAVAWPIRRPRGALAMSLLAVALLTLAMPLWHNMAAWCALRLAAGYASASAFICVAAWRAVPAGDPREAEASAVTYAGVGAGIALTGLACLALAAWDARADTVWMVLGGLALALSAAAWPGLRRQAAPTPARKASAAPAARLPRVIPALALHYGAFGVGYIIPATFLPAMAKEIIPDPAIFGWAWPLFGLAAAVSCLLVPRLARGGDSVQIWRAAQALMALGMLTVAVWHHIAAVILAAVLVGGTFMVITQAGMLAARRAAGASGPRAAALMTAAFAAGQILGPLAASWAAHWGADLPQALAASAALLALSAWRLGKITTDGNGAGHNAIASGPRGCAHQNHN
>LR134361.1|VEG65664.1|199135_200113_-|Argininosuccinate-lyase
MKPLRPLIAVLAAAAAFSGAAQAQTADWPAKPITMIVPYAPGGFADTRVRLLARKLGDTLGQPIVVENKAGAGGVVGTNLIARAAPDGYTIGTGNLAPMAVNPTLMKDMPYDPQKDLAPIILIENSPLVLSVNNDLPVKTLADLIALAKKEPGKLSFGSSGVGGAHHLSGEMFREQAKIDIVHVPYKGGSLAATDLMGGHISMMFEMGYSALPAIQGAKIHPIAVTSAKRLAVLPDVPTMAESGLPGFESYNWQGIVAPAGTPAPIIAKLNAEFNRILKEPDVQKAIADTGSQAGGGTPEEFGAFIKSETEKWAHVIKAGNIQLQ
>LR134361.1|VEG65674.1|213909_214749_-|3',5'-cyclic-adenosine-monophosphate-phosphodiesterase-CpdA
MARIHSLTRRDDAPAMLVQLTDSHLFGEPETSMLGVNTDASLRAVLRQIEADGKHPDLLLATGDMSQDGEAAAYRRLARVLSEAPALEQACIRCLPGNHDLPAVMRQELPEWSAPVTDVGAWRVVALDTTVPNSNAGHLPQSQLDLLEAALAEAPGRHTLIAMHHNPMQIDSHWHDSMMIDNPQALFKLLTRWPQVRVLLWGHVHHEFDRRRHNLRMLATPSTCFQFSIRDGKHVVDNMAPGYRWIKLYQDGSMATGVRRVQDALWHPALTSQDKAQAA
>LR134361.1|VEG65675.1|214933_217624_+|Sodium,-potassium,-lithium-and-rubidium/H(+)-antiporter
MDVGFLVFGLAGLLTLVCFMPPLAGRLKLPYSVLLAIVGCLLGIIVHVHGWAPSWIGDFLDSLERFEISSETFLMVFLPVLLFETALSMNVRRLMDDIGPILMMAIVAVVVCTVVVGVTLDAISSYGLVVCLLLGAIVATTDPVAVVGIFREVGAPKRLTTLVEGESLFNDAASIALYSVLLAVLGGHGELTASGIFNDFIVHFIGGGIAGFAMGRLACFLFAWLRGFPTAEITLTLTLAYLSFFISEHYLNVSGVVATVIAGLVVGSTGRTRMSPTTFEYLSSAWEQFGFWANSLIFLFAAMLIPKLMAAADWQELALVAVVFVATLVARAIVVFGLLPLLGLTRLGTKVSNPYKVVMLWGGLRGAVSLALALAVTEQTGVAEEARQFIAVATTSYVLLTLFINGISLRPLIRMLGLNQLSPVERTIRNQALAVALEDLQGKTEDVARAEHIGTEVRDRIRAVFDASLTSVHDGQVSQMTDDQRVAVGLAIVAQREEEMFFDILKAQIVDWRMAETLLARAERLEDAIRLGGIPGFERAIVADVRYSTGFRLALRLHYLFGFQGWLARELGQRFANLMSKRSVAQRLIAFAREQITPLLGEEATQRIVSLHQRRLDLIENAMQALNLQYPSYAQWLQESYLGRVAREMERIRYRDMLEQFLISGEVYADLMAQLKSRWAHIDKHPPLDIEMSAADLIKRVPLFEGLSADSLRAISKLLKPRLALPDQRVLTKGRHGEEMCFVASGAVAVHLPDHTMIELGSGEFFGELGLLGEEQLMPEVTSLGYSKLLMLSSRDFHALLARDEHLRERIQVVAKQRLRAIEVWKQFSQANAAPAPVSPPVSAPSPGQAAEAAEAAGASSGTDAQAASEVRDAQAPAQNGAPDAPSLGEPGVVRP
>LR134361.1|VEG65676.1|217620_218433_-|Isopentenyl-diphosphate-Delta-isomerase
MPKQLSDLYADLCARAQEPAPEGARALYIAGRRCGWATHAACDALRGAPGIAADGDTLRIGSDLQPGASLNDVLEQAAQLLRQANCLRGWRDELLDVLDGDEPLGVIERAAVRPLGLLTKAVHLNAWTPDGRLWVARRALSKSTDPGMWDTLVGGLASSREDLELALVRECGEEAGLDEPDLTQRSPLRTILRIHRRLPEGYQVEDVLTSTCVLSADVRPANRDGEVMEIATIDAATAVRQVAEGEFTLEAALVIIEDIMQRRAAGEIPA
>LR134361.1|VEG65677.1|218722_219880_+|Cytochrome-c-oxidase-subunit-2-precursor
MKKWRGILGACAMLIGSVAGAQVQDMPGGPKVNQLNLHEGVTAISRDIMWLHWMLLTICIVIFIGVFGVMFYSIWAHRKSRGHKAATFHEHLGVEVAWTVIPFIIVIAMALPATKTVVAMKDTSSADLTVKVTGYQWKWGYEYLDGSATGIKFLSTLSTPRAQIENREPKGEFYLMEVDNHLVVPVNKKIRIVLTAADVIHSWMIPDFGVKQDAIPGFLRDTWFNADKPGIYRGQCAELCGKDHAFMPIVVEVMAQADYDKWVEDQKKKMAANADDPNKEWTEAELVARGEKVFAANCVACHQANGKGIPGSFPPLDGDKVVLGPKAEQINTVLKGKPGTAMAAFGGQLNDVEIAAVISYTRHAWSNAGKGQDPTVQPKDVMAAR
>LR134361.1|VEG65678.1|219984_221592_+|Cytochrome-c-oxidase-subunit-1-beta
MSSVTVDHVSPGHGHGHDDHHHAIPTGWRRWLFATNHKDIGTMYLIFSFVMLLEGGTLALLLRTELFEPGLQFFRPELFNQFTTMHGLVMVFGAVMPAFVGFANWMIPMQIGASDMAFARMNNFSFWLLPVAAIMLTASFFVPGGATAAGWTLYAPLSLQMGPGMDLAIFALHIMGASSIMGAINIIVTILNMRAPGLTLMKMPLFCWTWLITAFLLLAVMPVLAAAITMVLTDRHFGTGFFNAAAGGDPVLYQHVFWFFGHPEVYIMILPAFGIVSAIVPAFARKKLFGYASMVYATASIAVLSFIVWAHHMFTTGMPVTGQLYFMYATMLISIPTGVKVFNWVATMWRGSMTFETPMLFSIGFIFVFTMGGFTGLILSVAPIDIQVHDTYYVVAHFHYVLVAGSLFALFAGAYYWVPKWTGRMYSEKLGKLHFWSTLISFNVTFFPMHFLGLAGMPRRYADYAGQFTTFHQMATIGAFWFGLSQLIFLWAMVRCYMGKGEPAAAKPWDGAEGLEWTVPSPAPFHTFETPPEVK
>LR134361.1|VEG65679.1|221623_221749_+|Uncharacterised-protein
MTPEQRRRNKIAGLVLLAFVIAVFAWTVLRGSALLSGVAVN
>LR134361.1|VEG65680.1|221758_221983_+|Protein-of-uncharacterised-function-(DUF2970)
MSDDLRETSQRKLSFLQTMKAVAWGFFGVRKGAGHREDVAKLNPVHVIVAGLLAAAIFVTVLVLIVRWAVSSLT
>LR134361.1|VEG65681.1|222021_222897_+|Cytochrome-c-oxidase-subunit-3
MSASHSVQGKEAPYYFVPADSGHPVRTAVALLFMGLSAAAWINGVSWAKWTLLAGFIGLIVVLYYWFGDAIHESEIGLNSKRIDGSYRWGMSWFIFSEVMFFAAFFGALWYTRTITTPWLGDMDHRLMLWPDFQAVWPNFGPAGVVEHFQTVGPFWLPTINTALLLSSGVTLTIAHHALRENHRGKTIFWLLATVVLGFVFVACQAYEYHHAYTELNLKFNSGAYGSLFYMLTGFHGFHVLLGATMLTVILIRLIRGHFTADHHFGFEGAAWYWHFVDVVWLGLYLFVYWF
>LR134361.1|VEG65682.1|223001_223202_-|Protein-of-uncharacterised-function-(DUF2909)
MRVFVVLAFIGILASLASALVYLMRDKGTTSRTVNALTVRIGLSVALFLFVLFAHHMGWIESTGLR
>LR134361.1|VEG65683.1|223241_224048_+|Uncharacterized-conserved-protein
MARPHSTRYTVAALLLLGVAVIILASLGQWQLRRGDERRAILAAIEAGRKQAPLPLTPATDPAEMTAWRSAQASGVWLPQFSVLLDNRNHDGKPGYWLATPLLLDADARRAVLVLRGWIPRVMGVQGQGPAQPQLPATPEGPQTVTGELSPRVPRLFELWSLGGPEQSALPASLPAAGGALPQVQNLPLDAYARATGLALLPTVLSQADGSADDGLVRDWPQPSVDFQQNTSYAVQWFAFASIAAVAWLVVLGGAIRRMRREKNTLGA

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Crispr_ID: LR134361_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134361_2

1437948-1438054

Orphan

Consensus_repeat	Method
TGCCGCAGGGCCGCCCCAAGGCAAAGG	CRISPRCasFinder

1 spacers

csa3

The CRISPR arrays of LR134361_2

>merge|LR134361|2|1437948-1438054|CRISPRCasFinder
TGCCGCAGGGCCGCCCCAAGGCAAAGGCCCCCTCGGGGGGCAGCAAGCCCGCATCGCGGGCGCAGCGTGGGGGCACCCTCTGCCGCAGGGCCGCCCCGAGGCAAAGG

>LR134361|2|2|1437948-1438054|CRISPRCasFinder
TGCCGCAGGGCCGCCCCAAGGCAAAGG	CCCCCTCGGGGGGCAGCAAGCCCGCATCGCGGGCGCAGCGTGGGGGCACCCTC
TGCCGCAGGGCCGCCCCGAGGCAAAGG

Protein	Signature genes	Signature genes Name	Protein_function
LR134361.1\|VEG66763.1\|1443490_1444096_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
LR134361.1\|VEG66764.1\|1444140_1444500_-\|Activator-of-Hsp90-ATPase-homolog-1-like-protein	unknown	unknown	gnl\|CDD\|226353
LR134361.1\|VEG66750.1\|1427814_1429197_+\|Uncharacterized-MFS-type-transporter-ycaD	unknown	unknown	gnl\|CDD\|341030
LR134361.1\|VEG66748.1\|1426558_1426981_-\|Uncharacterised-protein	unknown	unknown	unknown
LR134361.1\|VEG66753.1\|1431342_1432836_-\|CsgBAC-operon-transcriptional-regulatory-protein	unknown	unknown	gnl\|CDD\|225107
LR134361.1\|VEG66766.1\|1444919_1445855_-\|preprotein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
LR134361.1\|VEG66747.1\|1425076_1425955_+\|Carboxymethylenebutenolidase	unknown	unknown	gnl\|CDD\|223489
LR134361.1\|VEG66754.1\|1434240_1435296_+\|General-stress-protein-69	unknown	unknown	gnl\|CDD\|381328
LR134361.1\|VEG66760.1\|1441166_1441931_+\|PAP2-(acid-phosphatase)-superfamily-protein	unknown	unknown	gnl\|CDD\|239483
LR134361.1\|VEG66749.1\|1427224_1427728_+\|Putative-peroxiredoxin-sll1621	unknown	unknown	gnl\|CDD\|223750
LR134361.1\|VEG66761.1\|1441976_1442687_-\|Alanine--tRNA-ligase	unknown	unknown	gnl\|CDD\|225427
LR134361.1\|VEG66752.1\|1430085_1431105_-\|Biotin-synthase	unknown	unknown	gnl\|CDD\|273075
LR134361.1\|VEG66765.1\|1444496_1444811_-\|Transcriptional-repressor-smtB-homolog	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
LR134361.1\|VEG66757.1\|1438077_1438551_-\|Probable-rRNA-maturation-factor	unknown	unknown	gnl\|CDD\|237573
LR134361.1\|VEG66755.1\|1435302_1436931_-\|Apolipoprotein-N-acyltransferase	unknown	unknown	gnl\|CDD\|234721
LR134361.1\|VEG66756.1\|1436927_1437818_-\|Magnesium-and-cobalt-efflux-protein-CorC	unknown	unknown	gnl\|CDD\|226910
LR134361.1\|VEG66758.1\|1438540_1439566_-\|PhoH-like-protein	unknown	unknown	gnl\|CDD\|376820
LR134361.1\|VEG66762.1\|1442730_1443408_-\|Uncharacterised-protein	unknown	unknown	gnl\|CDD\|379203
LR134361.1\|VEG66751.1\|1429213_1430095_-\|EamA-like-transporter-family	unknown	unknown	unknown
LR134361.1\|VEG66759.1\|1439562_1440996_-\|(Dimethylallyl)adenosine-tRNA-methylthiotransferase-MiaB	unknown	unknown	gnl\|CDD\|237673

Protein	Function_ID	Function_description	E-value
LR134361.1\|VEG66763.1\|1443490_1444096_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	6.28377e-136
LR134361.1\|VEG66764.1\|1444140_1444500_-\|Activator-of-Hsp90-ATPase-homolog-1-like-protein	gnl\|CDD\|226353	COG3832, COG3832, Uncharacterized conserved protein [Function unknown].	1.38987e-13
LR134361.1\|VEG66750.1\|1427814_1429197_+\|Uncharacterized-MFS-type-transporter-ycaD	gnl\|CDD\|341030	cd17477, MFS_YcaD_like, YcaD and similar transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.55991e-92
LR134361.1\|VEG66753.1\|1431342_1432836_-\|CsgBAC-operon-transcriptional-regulatory-protein	gnl\|CDD\|225107	COG2197, CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription].	3.47486e-21
LR134361.1\|VEG66766.1\|1444919_1445855_-\|preprotein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	1.70829e-146
LR134361.1\|VEG66747.1\|1425076_1425955_+\|Carboxymethylenebutenolidase	gnl\|CDD\|223489	COG0412, COG0412, Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism].	1.29623e-69
LR134361.1\|VEG66754.1\|1434240_1435296_+\|General-stress-protein-69	gnl\|CDD\|381328	cd19102, AKR_unchar, uncharacterized aldo-keto reductase (AKR) superfamily protein. This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.	1.97717e-146
LR134361.1\|VEG66760.1\|1441166_1441931_+\|PAP2-(acid-phosphatase)-superfamily-protein	gnl\|CDD\|239483	cd03389, PAP2_lipid_A_1_phosphatase, PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.	1.41227e-47
LR134361.1\|VEG66749.1\|1427224_1427728_+\|Putative-peroxiredoxin-sll1621	gnl\|CDD\|223750	COG0678, AHP1, Peroxiredoxin [Posttranslational modification, protein turnover, chaperones].	1.23363e-75
LR134361.1\|VEG66761.1\|1441976_1442687_-\|Alanine--tRNA-ligase	gnl\|CDD\|225427	COG2872, COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only].	2.64325e-81
LR134361.1\|VEG66752.1\|1430085_1431105_-\|Biotin-synthase	gnl\|CDD\|273075	TIGR00433, biotin_synthase, biotin synthase. Catalyzes the last step of the biotin biosynthesis pathway. All members of the seed alignment are in the immediate gene neighborhood of a bioA gene. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin].	1.77047e-172
LR134361.1\|VEG66765.1\|1444496_1444811_-\|Transcriptional-repressor-smtB-homolog	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	6.34491e-16
LR134361.1\|VEG66757.1\|1438077_1438551_-\|Probable-rRNA-maturation-factor	gnl\|CDD\|237573	PRK13963, PRK13963, rRNA maturation RNase YbeY.	4.87087e-51
LR134361.1\|VEG66755.1\|1435302_1436931_-\|Apolipoprotein-N-acyltransferase	gnl\|CDD\|234721	PRK00302, lnt, apolipoprotein N-acyltransferase; Reviewed.	8.33705e-169
LR134361.1\|VEG66756.1\|1436927_1437818_-\|Magnesium-and-cobalt-efflux-protein-CorC	gnl\|CDD\|226910	COG4535, CorC, Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism].	7.27863e-107
LR134361.1\|VEG66758.1\|1438540_1439566_-\|PhoH-like-protein	gnl\|CDD\|376820	pfam02562, PhoH, PhoH-like protein. PhoH is a cytoplasmic protein and predicted ATPase that is induced by phosphate starvation.	2.26018e-140
LR134361.1\|VEG66762.1\|1442730_1443408_-\|Uncharacterised-protein	gnl\|CDD\|379203	pfam13468, Glyoxalase_3, Glyoxalase-like domain. This domain is related to the Glyoxalase domain pfam00903.	9.49209e-39
LR134361.1\|VEG66759.1\|1439562_1440996_-\|(Dimethylallyl)adenosine-tRNA-methylthiotransferase-MiaB	gnl\|CDD\|237673	PRK14325, PRK14325, (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional.	0

>LR134361.1|VEG66756.1|1436927_1437818_-|Magnesium-and-cobalt-efflux-protein-CorC
MSDPYPAPEATPARSAKPATKSLLDRLLSLVRREPEDREGIKAVLEAAHERELLDAESYKMIKGALAVSEGTVGDIMVPRSRMDLLDVTQPIPYLVASVIETAHSRFPVYEGDRDNIIGILLAKDLLRCMLEPNIEVRTLVRPAVFIPESKRLNVLLHEFRASRNHQAIVIDEHGGISGLVTMEDVLEQIVGDIEDEFDETEEDSIFPEGENQWRVLAATDISHFNDVFGCQLPDDEYDSVGGWMGGQLGRIPRRGDTAEFDGLRLEVARGDARRAIWLRVKRNAPSQASRPSDEA
>LR134361.1|VEG66755.1|1435302_1436931_-|Apolipoprotein-N-acyltransferase
MTQSPRSRKLRGAAGLMLAGAAHALTFSPGPLPAWALATTQVLMLAIAARVTLYAPSAKQAWARGWLFSFTSYALGLYWIFISLHRYGDLAAPLAVAAVLALSAFLALFPATASALARHYAPLEPGSAPARILSGTLAWAAMWAGFEWLRAVLLTGFPWLNIGYAQVDGPIAGWAPLLGVHGMAFLAAFAAAALASLWQPSRKAGTGSRHALAAGIALALAAAGWPLSRIDWSAPSGDPLNVRLVQGNIEQSQKFDPALLDQSLVRHLDLAAMPAAPGVPDPQLIILPETVLPIFQDQLDPRVWAVWRDLAAQRNTVIAMGVPLHDRVNGRDRYTNSVMGFDGSTPVEQLVAGTTSMRYDKRHLVPWGEYVPPGFHWFVEMLNIPLGDFDRGAVRQTPFAVGGQHIAFNICYEDLFGPDLLPSLQPGPNGEPGATILVNVSNLGWFGDSWALRQHLQIGRLRTMETARPMLTATNTGITAAIDAKGRVAAQLAPLQAGVLPVAVQGMTGLTPYARFGDKTALALIGLALIAAFGSGRKTRRA
>LR134361.1|VEG66754.1|1434240_1435296_+|General-stress-protein-69
MSSKTSFPTRPLGQSGMDITRIGLGAWAMGGNGWAIGWGPQDDADSVAAIRRAVERGINWIDTAAVYGLGHSEEIVRRALAQMAPDARPYVFTKCGLTWSPEQPQAMPRRTGAPASIRRELEDSLRRLGVERIDLYQMHWPAGDGTPLEVYWQELLDLKREGKVRAVGLSNHNLAQLQQAEALGHVDTLQPPFSAIQRAAASDLIPWCDRHGTGVIVYSPMQSGLLTGSFSMERARALPADDWRARNAEFTSPGIERNLALADAFKPIAERHGTTVAAVAAGWTLAWPGVTGAIVGARSAAQVDGLLGAASLELDAEDMEAIADAIERTGAGAGPLRPPEDGGALPSNLFA
>LR134361.1|VEG66753.1|1431342_1432836_-|CsgBAC-operon-transcriptional-regulatory-protein
MTANTAAPHPHRQHLQRIIAGLNEGIILLEADGAIAWANDSALRLHGTDTLDELGGTPAGYRKRYILTYRNHHRVPARQYPLDRLAASEPFDELLLDLARKDDDEFLRNVRASGLNLDSAEGTDYRVLILHDQTEQINAEERFERAFGANPAPALICQLSDLRYVKVNQGFLEMTGYARDAVLGKSAYELDVLDGSGDKDNAVAMLNEGQTIAQREGVLKLADGSTKFVIVAGQPIDMQGVPCMLFTFIDLEARKRTELALRESEERFSKAFRLAPVPMAVCDGETLLALDLNAAFASATGALPQDGIGHALADLGLQLQEELEASLKRAESARNHDVTLTAKDGNPLDCLLSAEPVTIGGQPRVLLAIQDITDRKRSETELLTAIEAVMQDTSWFSRSVIEKLAQLREPAPATRDVAELAQLTTREREVLGLMCQGHDDDGIAQSLKLSRNTVRNHVATIYSKIGVHRRSAAIVWARDRGITGHERARARDKRPKA
>LR134361.1|VEG66752.1|1430085_1431105_-|Biotin-synthase
MQTAYIPVPTVAKPATAPAWSAADIMALYELPFMDLVFRAQQAHRAHFDPNAIQLSSLLSIKTGGCPEDCAYCPQSSHYDTGLDADKLMPLADVVAAARKAQEGGAQRFCMGAAWRSPKPHHLEAVAEMVSAVKALGLETCVTLGMLREGQAEQLKSAGLDYYNHNLDTSPEFYGKIISTRTYQDRLDTLDRVRDAGINVCCGGIVGMGESRRERAGLIAQLASMEPYPESVPINNLVQVEGTPLAGVEALDPFEFVRTIAVARITMPRAAVRLSAGREAMDDALQALCFMAGANSMFYGDALLTTANPQMEADQRLLQRLGMRIDAAPHTHHDTSTCR
>LR134361.1|VEG66751.1|1429213_1430095_-|EamA-like-transporter-family
MPLTPGLLYLLASVACSVTVAVLLKLARRYQVDVRQAIAMNYAVAALLCWTVLRPDAAALLAPQTPWLVLAALGVLLPSVFLAMAAAVRHAGIVRSDAAQRLSLFIPLLAAFLLFGESVSGRKLAATALAACALYCLLRRPARPQIPGESASESGRAMWLWPLAVWVGYGVIDILFKQMARAGTAFAGGLLLAFVIAGLLMLAYLLWRRVRCQFRHLAAGAALGLANFGNILTYIRAHQSLPEHPALVFASMNMGVITLGTLVGALAFREPLTRLNLLGIALALTAIVLMAPW
>LR134361.1|VEG66750.1|1427814_1429197_+|Uncharacterized-MFS-type-transporter-ycaD
MLATISSFSSLYFATLLMLIGTGLFNTYMGLRLTAQSVNEVWIGALIAGYYLGLVCGARLGHKLIIRVGHIRAFVACAAIATSMILAQTLVDSMPLWLVFRVVSGIVMVTEFMVIESWLNEQTENHQRGRVFSVYMVVSGLGTVLGQLALTAYATLDLRPLTLVAMCLVLCLVPIAVTARSHPPTPLPAPLDIRFFMRRVPLSMTVLFVAGNLSGAFYGLAAVYGAKHGLSTSQAAIFVAAAVTAGLLSQWPMGWLSDRINRAGLIRFNALLLVLLPVVMWGWIVLPYWALVAMSCVFGVLQFTLYPLGAAFANDHVESERRVSLSAVLLMTYGVGACVGPMIAGVLMSLAGPSMYYVFISACALILVWHVRPTRVTGAHQVEEAPTHFVPMPDTLQSSPAAAVLDPRVDPATDIAMEMVQPETAPVATAEAPQAEPAVEASGDPADVAADDERERRTGT
>LR134361.1|VEG66749.1|1427224_1427728_+|Putative-peroxiredoxin-sll1621
MTIKVGDRVPDGTLTEFIETETAGCSLGPNAFQVADLTRGKTIALFAVPGAFTPTCSAKHLPGYVEQAAALKAKGVDEIWCVSVNDAFVMGAWGREQKTEGKVRMLADGSALWTKELGLELDLVQRGMGVRSQRYSALIVDGVVKQLNVEAAGKFEVSDAATMLSQV
>LR134361.1|VEG66748.1|1426558_1426981_-|Uncharacterised-protein
MRKILTGLALTLASAATAWAAPDAAEQAQYESFIIAAGASNGAARACGASEPDLAQHQATARKNLLQYAQEYGFTSGGYEGLFQKGQGQGTAMMEEMKRSGVDGCRGVLGGFQSERVMEYEDMKRALAEVSDGLPGEKAQ
>LR134361.1|VEG66747.1|1425076_1425955_+|Carboxymethylenebutenolidase
MNDQDAHFDSLLPPLRLDRRGFIATTVATGFSLAAGQAVAQTTITTDTSGLLAGKVDIPVQDGKMPAYRAAPKGKKDLPTVLVVSEIFGVHEYIQDVCRRLAHQGYLAIAPELFARQGDPSKYTEIPKLQAEIIGKVPDAQVTSDLDATAAWAASNGGNPDRLGIVGFCWGGRQVWLYAAHNPKLKAGAAWYGQLGGQPSELKPRSVLSQVNALKAKVLGAYGGKDAGIPMTDVDKMRLELAQGPAAAKASRIDVYPDAPHAFHADYRPSYRKAEAEQAWTRMLDWFKQNGL
>LR134361.1|VEG66757.1|1438077_1438551_-|Probable-rRNA-maturation-factor
MKPELSLSVQYGIEEARLPRWRLRRWAERALAGAAEDGLVEFSAAELSLRLVGAAEGRRLNRDFRGRDYATNVLTFEYGVDPLGVARGDIVMCVPVLVREAREQRKALLDHAAHLTIHGVLHALGYDHIKARDAKRMEALETATLAAMRIADPYVAA
>LR134361.1|VEG66758.1|1438540_1439566_-|PhoH-like-protein
MTTPRSRARRSMPIVVTLDGDNTHLANLCGPLDENLRQLADGMNVKLARRGSRVTIEGELAELAGRVLRRFHEQAVHRALSVDDIQLGLVEIGVGRQEQELKEEQAREADPLPALDDESDGIALRTKRSDLRPRTPRQRDYLNNILKHDITFGVGPAGTGKTWLAVACAIDAMERDTVQRLVLTRPAVEAGERLGFLPGDLAQKVDPYLRPLYDALYDLMGFEKVQRLFEKQTIEIAPLAYMRGRTLNHAFVILDEAQNTTPEQMKMFLTRIGFGSKAVITGDPSQVDLPRGQDSGLAHAVKVLHDVQGIATTRFTSRDVVRHPLVARIVDAYDRAAEDEA
>LR134361.1|VEG66759.1|1439562_1440996_-|(Dimethylallyl)adenosine-tRNA-methylthiotransferase-MiaB
MQETTLKRANAAHDGASAALPAADAGSPRKLYIRTFGCQMNEYDSDKMADVLRGDQGLELTDNPEDADVILFNTCSVREKAQEKVFSDLGRVQHLKKTNPNLVIGVGGCVASQEGEAIVKRAPYVDVVFGPQTLHRLPELIKRRRDEGRSQVDISFPEIEKFDNMPPPRVEGATAFVSIMEGCSKYCSFCVVPYTRGEEVSRPFEDVLVEVADLADQGVKEVTLLGQNVNAYRGRMTDSDEIADFAMLLEYVHEIPGIERIRYTTSHPKEMTQRMVDAYARLPKLVSFLHLPVQAGSDRVLAAMKRGYTTLEFKSVVRRLRAARPDLTLSSDFIVGFPGETEEDFEKTMKLIEDVGFDTSFSFVYSRRPGTPAADLHDDTPQDVKLRRLQRLQALINEQAATIARNMIGTRQRLLVEGPSRRDPNELMGRTENNRIVNFAAPARLIGQMVDVIITEAHTNSLRARVADVDRIPQEAE
>LR134361.1|VEG66760.1|1441166_1441931_+|PAP2-(acid-phosphatase)-superfamily-protein
MNTNPLTPSAAAPAIDAAAGRSEPDQFRNPFSALTWVLLGCALALAASACALWVDLPLAVWIKQSVSDSVNLSFEWIGELGESGPYIGVALAFYVIGLVGLARGWRNPVRMSYASMARGSLLMLSTLAVGGLVVLVLKRSVARARPELFFEKGIYGLGESFSRVQLYNSFPSSHTYAAFAVAVVLGILAPRWRWVFLLLAVLVAMSRLVNLDHYLSDVMTAAGIAVLVGHVLAPRVLGATYQWPLRAPWRWWKK
>LR134361.1|VEG66761.1|1441976_1442687_-|Alanine--tRNA-ligase
MLSTRKRFDEDPYLDRCDATVIAVGPEGVELDQTVCYARSGGQAGDCGTLTLADGRAWALTDTVYADDRKRILHVLEGGAALQVGERVSVAIDWPRRHRLMRLHTCLHLLGSLVPAPVTGCSISPDSARIDFDLPESTLDKADLTERLNALINARTGISINCITPEELAAEPDLVRTVGAAPPAGTASIRIVEIPGVDRQPCGGTHVANTGEIGAVAVTKIEKKSRTNRRVVVNFA
>LR134361.1|VEG66762.1|1442730_1443408_-|Uncharacterised-protein
MKLVIDHLVVAAADLDSGTDYVAGLLGIAPSGGGAHPRMGTHNRVLGMAGGLYLEVIAIDPQATAPSRPRWFGLDQDAVRARLAQGPYLAHWAARVEAPLDLSRMQAEHPARIPPAIPMERGHLRWRLTVPEDGSLPAWRVAGHAAGDGLLPTLIQWDVADYPGISLPRQNLTLRQLSGSHPQAGLLRQGLAWLGADHLIQLEQADGPPRLSAQIETASGLKILA
>LR134361.1|VEG66763.1|1443490_1444096_-|ATP-dependent-Clp-protease-proteolytic-subunit
MQDVMQYVPMVVEQSGRGERSFDIYSRLLRDRIIFLNGEVNDSVSALVCAQLLFLESENPTKPIHLYINSPGGVITSGLAMYDTMQFITAPVHTLCMGTARSMGSFLLMAGEPGERCALANASVHVHQPLGGFQGQASDVLIHAEEMRRTKDRVTRVYAQHCGRSYEEVERKLDRDCYMSAEEALEWGLIDRVIKRRDLDA
>LR134361.1|VEG66764.1|1444140_1444500_-|Activator-of-Hsp90-ATPase-homolog-1-like-protein
MKPTAPGDQPEDIVLEYELDAPPEKVWRAISIPEFREQWLPGQALASAEPTDSTPPEEICYRMRDEEPPFLESVVTFQLRPAADGRTVLRIVHALADARLEGGKLAAANDAGPFLMRAA
>LR134361.1|VEG66765.1|1444496_1444811_-|Transcriptional-repressor-smtB-homolog
MLENDIFKALADPTRRAIFEKLAAGGMNASALRVGMEISQPAMSQHLSVLRKARLVREQKQGRFVNYEVDPDGLALIAGWLTKYRAYWPTRIDALNALLKDMDQ
>LR134361.1|VEG66766.1|1444919_1445855_-|preprotein-translocase-subunit-SecF
MEFFRIHRTIPFMRHALVLNIISLVTFLAAVFFIITRGFHLSIEFTGGTVMEVNYAQTAQLENVRGVVSKLGYTDFQVQNFGTSHDVMIRLPLQEGQTSATQSETVMAALKTADSGVELRRVEFVGPQVGQELLHNGLMALLVVVIGIMVYLGFRFEWKFAVAGVIANLHDVVIILGFFAFFQWEFSLSVLAGVLAVLGYSVNESVVIMDRIRENFRKYRKADVQEVINSAITQTISRTIITHGSTQMMVLAMLFFGGPTLHYFAMALTIGIWFGIYSSVFVAAALAMWLGVKREDLVKPVKKEGEEGEAA

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Crispr_ID: LR134361_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134361_3

1453040-1453254

Orphan

Consensus_repeat	Method
CCGAGGGGCTGTTTCCCCTTGGGGCGGCTCGGCGGGAGGGAGGGCCCCCAC	PILER-CR

2 spacers

csa3

The CRISPR arrays of LR134361_3

>merge|LR134361|3|1453040-1453254|PILER-CR
CCGAGGGGCTGTTTCCCCTTGGGGCGGCTCGGCGGGAGGGAGGGGCCCCCCACGCTGCGCACGCTATGCGTGCTTGCTGCCCCCCCGAGGGGGGCTGGCCCGCCTTGGGGCGGCCCGGCGGCGGGCCGGCTATTTTTCTGGGGGGCCGTTTGTGCTTGCTGCCTCCGAGGGGCTGTTTCCCCTTGGGGCGGCTCGGCGGGAGGGAGGGCCCCCAC

>LR134361|3|1|1453040-1453254|PILER-CR
CCGAGGGGCTGTTTCCCCTTGGGGCGGCTCGGCGGGAGGGAGGGGCCCCCC	ACGCTGCGCACGCTATGCGTGCTTGCTGCCCCCCCGAGG
GGGGCTGGCCCGCCTTGGGGCGGCCCGGCGGCGGGCCGGCTATTTTTCTGG	GGGGCCGTTTGTGCTTGCTGCCTCCGAGGGGCTGTTTCCCCT
TGGGGCGGCTCGGCGGGAGGGAGGGCCCCCAC

Protein	Signature genes	Signature genes Name	Protein_function
LR134361.1\|VEG66767.1\|1445908_1447789_-\|preprotein-translocase-subunit-SecD	unknown	unknown	gnl\|CDD\|235615
LR134361.1\|VEG66766.1\|1444919_1445855_-\|preprotein-translocase-subunit-SecF	unknown	unknown	gnl\|CDD\|237275
LR134361.1\|VEG66782.1\|1465431_1466157_+\|Uncharacterised-protein	unknown	unknown	unknown
LR134361.1\|VEG66776.1\|1457308_1457893_-\|Probable-transcriptional-regulatory-protein-pdtaR	unknown	unknown	gnl\|CDD\|226230
LR134361.1\|VEG66763.1\|1443490_1444096_-\|ATP-dependent-Clp-protease-proteolytic-subunit	unknown	unknown	gnl\|CDD\|178955
LR134361.1\|VEG66768.1\|1447898_1448243_-\|preprotein-translocase-subunit-YajC	unknown	unknown	gnl\|CDD\|235518
LR134361.1\|VEG66772.1\|1451741_1452896_+\|Leucine-,-isoleucine-,-valine-,-threonine-,-and-alanine-binding-protein-precursor	unknown	unknown	gnl\|CDD\|380556
LR134361.1\|VEG66770.1\|1449497_1450556_-\|S-adenosylmethionine:tRNA-ribosyltransferase-isomerase	unknown	unknown	gnl\|CDD\|234666
LR134361.1\|VEG66773.1\|1453483_1454932_+\|D-alanyl-D-alanine-carboxypeptidase-dacB-precursor	unknown	unknown	gnl\|CDD\|224938
LR134361.1\|VEG66769.1\|1448364_1449501_-\|Queuine-tRNA-ribosyltransferase	unknown	unknown	gnl\|CDD\|234642
LR134361.1\|VEG66780.1\|1461341_1462562_+\|Rubredoxin-NAD(+)-reductase	unknown	unknown	gnl\|CDD\|224171
LR134361.1\|VEG66771.1\|1450690_1451506_-\|Pectin-degradation-repressor-protein-kdgR	unknown	unknown	gnl\|CDD\|224332
LR134361.1\|VEG66781.1\|1462565_1465292_+\|Nitrate-reductase	unknown	unknown	gnl\|CDD\|239155
LR134361.1\|VEG66778.1\|1459623_1460454_+\|Bicarbonate-transport-system-permease-protein-CmpB	unknown	unknown	gnl\|CDD\|130251
LR134361.1\|VEG66777.1\|1458287_1459589_+\|Nitrate-transport-protein-NrtA-precursor	unknown	unknown	gnl\|CDD\|372585
LR134361.1\|VEG66774.1\|1455117_1455756_+\|Uracil-phosphoribosyltransferase	unknown	unknown	gnl\|CDD\|234653
LR134361.1\|VEG66775.1\|1455788_1457204_-\|Siroheme-synthase	unknown	unknown	gnl\|CDD\|182606
LR134361.1\|VEG66764.1\|1444140_1444500_-\|Activator-of-Hsp90-ATPase-homolog-1-like-protein	unknown	unknown	gnl\|CDD\|226353
LR134361.1\|VEG66765.1\|1444496_1444811_-\|Transcriptional-repressor-smtB-homolog	csa3	COG0640_csa3_CAS-I-A	gnl\|CDD\|238042
LR134361.1\|VEG66779.1\|1460458_1461334_+\|Bicarbonate-transport-ATP-binding-protein-CmpD	unknown	unknown	gnl\|CDD\|224041

Protein	Function_ID	Function_description	E-value
LR134361.1\|VEG66767.1\|1445908_1447789_-\|preprotein-translocase-subunit-SecD	gnl\|CDD\|235615	PRK05812, secD, preprotein translocase subunit SecD; Reviewed.	0
LR134361.1\|VEG66766.1\|1444919_1445855_-\|preprotein-translocase-subunit-SecF	gnl\|CDD\|237275	PRK13022, secF, protein translocase subunit SecF.	1.70829e-146
LR134361.1\|VEG66776.1\|1457308_1457893_-\|Probable-transcriptional-regulatory-protein-pdtaR	gnl\|CDD\|226230	COG3707, AmiR, Response regulator with putative antiterminator output domain [Signal transduction mechanisms].	2.10802e-40
LR134361.1\|VEG66763.1\|1443490_1444096_-\|ATP-dependent-Clp-protease-proteolytic-subunit	gnl\|CDD\|178955	PRK00277, clpP, ATP-dependent Clp protease proteolytic subunit; Reviewed.	6.28377e-136
LR134361.1\|VEG66768.1\|1447898_1448243_-\|preprotein-translocase-subunit-YajC	gnl\|CDD\|235518	PRK05585, yajC, preprotein translocase subunit YajC; Validated.	8.43661e-43
LR134361.1\|VEG66772.1\|1451741_1452896_+\|Leucine-,-isoleucine-,-valine-,-threonine-,-and-alanine-binding-protein-precursor	gnl\|CDD\|380556	cd06333, PBP1_ABC_RPA1789-like, type 1 periplasmic binding-protein component (CouP) of an ABC system (CouPSTU; RPA1789, RPA1791-1793), involved in active transport of lignin-derived aromatic substrates, and its close homologs. This group includes RPA1789 (CouP) from Rhodopseudomonas palustris and its close homologs in other bacteria. RPA1789 (CouP) is the periplasmic binding-protein component of an ABC system (CouPSTU; RPA1789, RPA1791-1793) that is involved in the active transport of lignin-derived aromatic substrates. Members of this group has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP).	1.30675e-144
LR134361.1\|VEG66770.1\|1449497_1450556_-\|S-adenosylmethionine:tRNA-ribosyltransferase-isomerase	gnl\|CDD\|234666	PRK00147, queA, S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional.	0
LR134361.1\|VEG66773.1\|1453483_1454932_+\|D-alanyl-D-alanine-carboxypeptidase-dacB-precursor	gnl\|CDD\|224938	COG2027, DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane].	2.62567e-94
LR134361.1\|VEG66769.1\|1448364_1449501_-\|Queuine-tRNA-ribosyltransferase	gnl\|CDD\|234642	PRK00112, tgt, queuine tRNA-ribosyltransferase; Provisional.	0
LR134361.1\|VEG66780.1\|1461341_1462562_+\|Rubredoxin-NAD(+)-reductase	gnl\|CDD\|224171	COG1251, NirB, NAD(P)H-nitrite reductase [Energy production and conversion].	0
LR134361.1\|VEG66771.1\|1450690_1451506_-\|Pectin-degradation-repressor-protein-kdgR	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	7.25304e-54
LR134361.1\|VEG66781.1\|1462565_1465292_+\|Nitrate-reductase	gnl\|CDD\|239155	cd02754, MopB_Nitrate-R-NapA-like, Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored tetraheme cytochrome. Members of the MopB_Nitrate-R-NapA CD belong to the molybdopterin_binding (MopB) superfamily of proteins.	0
LR134361.1\|VEG66778.1\|1459623_1460454_+\|Bicarbonate-transport-system-permease-protein-CmpB	gnl\|CDD\|130251	TIGR01183, Nitrate_transport_permease_protein_NrtB, nitrate ABC transporter, permease protein. This model describes the nitrate transport permease in bacteria. This is gene product of ntrB. The nitrate transport permease is the integral membrane component of the nitrate transport system and belongs to the ATP-binding cassette (ABC) superfamily. At least in photosynthetic bacteria nitrate assimilation is aided by other proteins derived from the operon which among others include products of ntrA, ntrB, ntrC, ntrD, narB. Functionally ntrC and ntrD resemble the ATP binding components of the binding protein-dependent transport systems. Mutational studies have shown that ntrB and ntrC are mandatory for nitrate accumulation. Nitrate reductase is encoded by narB. [Transport and binding proteins, Anions].	3.55145e-73
LR134361.1\|VEG66777.1\|1458287_1459589_+\|Nitrate-transport-protein-NrtA-precursor	gnl\|CDD\|372585	pfam13379, NMT1_2, NMT1-like family. This family is closely related to the pfam09084 family.	7.15533e-128
LR134361.1\|VEG66774.1\|1455117_1455756_+\|Uracil-phosphoribosyltransferase	gnl\|CDD\|234653	PRK00129, upp, uracil phosphoribosyltransferase; Reviewed.	4.37052e-126
LR134361.1\|VEG66775.1\|1455788_1457204_-\|Siroheme-synthase	gnl\|CDD\|182606	PRK10637, cysG, siroheme synthase CysG.	0
LR134361.1\|VEG66764.1\|1444140_1444500_-\|Activator-of-Hsp90-ATPase-homolog-1-like-protein	gnl\|CDD\|226353	COG3832, COG3832, Uncharacterized conserved protein [Function unknown].	1.38987e-13
LR134361.1\|VEG66765.1\|1444496_1444811_-\|Transcriptional-repressor-smtB-homolog	gnl\|CDD\|238042	cd00090, HTH_ARSR, Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.	6.34491e-16
LR134361.1\|VEG66779.1\|1460458_1461334_+\|Bicarbonate-transport-ATP-binding-protein-CmpD	gnl\|CDD\|224041	COG1116, TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism].	3.94097e-118

>LR134361.1|VEG66772.1|1451741_1452896_+|Leucine-,-isoleucine-,-valine-,-threonine-,-and-alanine-binding-protein-precursor
MTPRRTLMAAALAALLAAGAAPALAQVKIGATLSTTGPQASLGIPERNTISLLPTEIGGVKVEYVVLDDASDTTRAVSNSHKLISENKVDLIVGSTTTPNTMAMLDTVASGTTPVITLASSARLIEPMDDKRRWVFKTPHSDSLMAEGIARHAAANGVKKLAFIGFNNALGETFWVEIEKAAKKHGIEVVGKEAFAPTDTSAVAQTLKVVGAAPDAVVVGASGTPAAMPARALRERGYKGKIYFNHGVANNDFLRVCGDACEGAWVPVGPVMVADLLPDDNPVKSTAQAFAKKYEAANGAGSVSLFAAYTWDVGLLLQQAIPVALKTAKPGTSEFRAALRDALENVKNLPTATGVVNMSPTDHNGLDERALVMATVASGKWRLK
>LR134361.1|VEG66771.1|1450690_1451506_-|Pectin-degradation-repressor-protein-kdgR
MSTTSSTGIQSAEIALDVLTRLAELGGALSVSELGRSLDMPRAKVHRYLVSLERRGYVEQDAASARYRLGPQALHTGLAALAEVDFVKLAAGCLDSLSAAIGQTVFISVWGQHGPTIVQWRDARLPVTVNVRVGSVLPLLNSATGRVFAAWLPESLALPRALSEWDALRSHDPDAAQVLDAAAAPTDPAAALRRQWQATRQRGYASVSGHLLHGIDSAAVPVLDAQGHLAGAITSLGLHGGFDLSPDGEPVRALVGAAADCSRRLGWSPAR
>LR134361.1|VEG66770.1|1449497_1450556_-|S-adenosylmethionine:tRNA-ribosyltransferase-isomerase
MTQSLTVSDFNYELPPELIAQAPAAERTGSRLLHLDGAGHLHDRQFADLASLLRPQDLLIFNDTRVIKARLNGHKITGGKIEVLVERITEPDRVLAHVRASKSPGPGMVLRLADAFDATVLGREGELFDIRFPGPVLELLDAHGATPLPPYITHEADTGDDERYQTVYAREPGAVAAPTAGLHFDQPTLDRLAAMGVERAFVTLHVGAGTFQPVRVDNLADHVMHAEWFTVPQATVDAIAVARSRGGRVIAVGTTSVRALESAAAQTEGRTAPGLPLASAQGDTRLFITPGYRYRVIDALVTNFHLPQSTLLMLVSALAGVEPIRRAYAHAVAERYRFFSYGDAMFIESPAP
>LR134361.1|VEG66769.1|1448364_1449501_-|Queuine-tRNA-ribosyltransferase
MTGLNFELLATDGGARRGRITLNHGVVETPIFMPVGTYGSVKAMLPHELKEIGSQIVLGNTFHLWLRPGTEIMEKHGGLHGFMQWDKPILTDSGGFQVFSLQGMRKITEEGVKFASPIDGARLFLTPEESMRIQRSLNSDIVMVFDECTPYEIDGRPATVEEAARSMRMSLRWARRSREEFDRLQNPNALFGIVQGGMYEALRDESLAGLQEIGFHGYAIGGLSVGEPKEDMMRILAHVTPKLPAQAPRYLMGVGTPEDLVEGVSRGVDMFDCVMPTRNARNGWLFTRFGDVKIRNAKYRDDTRPLDPSCGCHTCANFSRAYLHHLQRANEITGARLNTLHNLHFYLTIMKEMREAIAEGRFDAWRAQFAADRARGVD
>LR134361.1|VEG66768.1|1447898_1448243_-|preprotein-translocase-subunit-YajC
MSVIDTASLVVAQAAAPEGNALMGMLPIILMFVILYFLMIRPQMKRQKEHRNLIAALAKGDEVVTAGGLLGKVTKVNDSYVTVEVSELADKPVEVIMQKSSVSTVLPKGTIKAL
>LR134361.1|VEG66767.1|1445908_1447789_-|preprotein-translocase-subunit-SecD
MNRYPLWKYITVLVAVIIGLLYTLPNFYGESPAVQVSSAKATIKVDPAMLSRVEQILTDAKIPNEGVYYEQNGTLGTVRARFASTDLQLQARDLIDKSLNTVAGDPHYTVALNLLPASPAWMRALGWFAPKPMYLGLDLRGGVHFLLQVDMQGALTARYDSLAADVRSVLRDQKVNVAGVERSGMAIAATFANSDDRDRAISTLRSRLPDLEFTEREENGKPLLMAALNPAAVTRVQDSALKQNINTLHNRINELGVAEPVIQQQGGDRIVVQLPGVQDVAKAKELLGRTATLEIRMVDDTPAAQAALLGGSVPFGLERYNDRDGRPILVRRQVILTGENLQDAQPGRDSQTQQAAVHLTLDSKGARIFRDVTRDNIGKRMAILLFENGKGEVVTAPVIRSEIAGGQVQISGSMSSEEAADTALLLRAGALAAPMSIIEERTIGPSLGADNIAKGFYSTLYGFLAIAAFIILYYHLFGVFSTIGLTMNVLLLLALLSMLQATLTLPGIAAIALTLGMAIDSNVLINERIREELRAGASPQQAIHHGFERAWGTILDSNLTTLIVGLALLAFGSGPIRGFAVVHVLGILTSMFSSVVGVRALANLWYGRKKKLTSISIGEVWKPKTN
>LR134361.1|VEG66766.1|1444919_1445855_-|preprotein-translocase-subunit-SecF
MEFFRIHRTIPFMRHALVLNIISLVTFLAAVFFIITRGFHLSIEFTGGTVMEVNYAQTAQLENVRGVVSKLGYTDFQVQNFGTSHDVMIRLPLQEGQTSATQSETVMAALKTADSGVELRRVEFVGPQVGQELLHNGLMALLVVVIGIMVYLGFRFEWKFAVAGVIANLHDVVIILGFFAFFQWEFSLSVLAGVLAVLGYSVNESVVIMDRIRENFRKYRKADVQEVINSAITQTISRTIITHGSTQMMVLAMLFFGGPTLHYFAMALTIGIWFGIYSSVFVAAALAMWLGVKREDLVKPVKKEGEEGEAA
>LR134361.1|VEG66765.1|1444496_1444811_-|Transcriptional-repressor-smtB-homolog
MLENDIFKALADPTRRAIFEKLAAGGMNASALRVGMEISQPAMSQHLSVLRKARLVREQKQGRFVNYEVDPDGLALIAGWLTKYRAYWPTRIDALNALLKDMDQ
>LR134361.1|VEG66764.1|1444140_1444500_-|Activator-of-Hsp90-ATPase-homolog-1-like-protein
MKPTAPGDQPEDIVLEYELDAPPEKVWRAISIPEFREQWLPGQALASAEPTDSTPPEEICYRMRDEEPPFLESVVTFQLRPAADGRTVLRIVHALADARLEGGKLAAANDAGPFLMRAA
>LR134361.1|VEG66763.1|1443490_1444096_-|ATP-dependent-Clp-protease-proteolytic-subunit
MQDVMQYVPMVVEQSGRGERSFDIYSRLLRDRIIFLNGEVNDSVSALVCAQLLFLESENPTKPIHLYINSPGGVITSGLAMYDTMQFITAPVHTLCMGTARSMGSFLLMAGEPGERCALANASVHVHQPLGGFQGQASDVLIHAEEMRRTKDRVTRVYAQHCGRSYEEVERKLDRDCYMSAEEALEWGLIDRVIKRRDLDA
>LR134361.1|VEG66773.1|1453483_1454932_+|D-alanyl-D-alanine-carboxypeptidase-dacB-precursor
MTGRANKRVGGLKRWLAGGLLAAVASAAWAQVPGLPPNVVNAWKASKLPDSSLSLVVQEVGGPRLVALNAKESRNPASVMKLVTTWAALSELGPNYVWRTEFMTAPGARPDAKGVLSGPLYLRAGGDPQFLLQDLWVLLRELRLRGVKQINDLVIDRSIFGQVATDPGAFDGAPDRAYNASPDALMVGFGALRLLFTPDPAANKWVPLIDPPLPGLKIEGRVEWSDARCPGPPVVTTEPLITQQGVTIRVNGKVAGSCGEFSLYRLALSQPDYATEVFRMLWKELGGTFKGQVRSGMVPPDAVVLASHDSPTLAEAIRQINKRSNNVMARTLLLTLGAERGRRPATVASSEAVAKGLLAKQGLDMPELVIDNGAGLSRDARVSADSLASMLTVAWNSPVMPEYISSFAIAGVDGTVRRRLKGDGTAGMAHLKTGSLRDVRSIAGYVLGASGKRYVVVSIVNHEQAGAVRAFDDALIAWLTEQ
>LR134361.1|VEG66774.1|1455117_1455756_+|Uracil-phosphoribosyltransferase
MPVHEIRHPLIRHKLGIMRRADLSTKSFRELSQEVGALLTYEASKDLPLAPATVEGWCGPVEVEKIAGKKVTVVPILRAGIGMLDGVLSLIPGAKVSVVGVARNEETLEAHTYLERLVGELDQRLALIVDPMLATGGSMVAAIDLLKRAGCKEIRALVLVAAPVGIDAVLAKHPDVHIYTASIDDGLNEHGYIMPGLGDAGDRIFGTTQKTE
>LR134361.1|VEG66775.1|1455788_1457204_-|Siroheme-synthase
MTLFPIFADLKDRLVLVVGGGAVAERKTLSLLEASADVLVGAPALTPALAALAAEGRIRHLSGRFDPAWLNEAWLVVAATDDRVTNAAVSEAARARRIFSNVVDDPELSSFQVPSIVDRSPVIVAISSSGVAPVLARRIRERIESLFDHTLGQLAGLAASYRKRIRASHPDLGARRRFYDWLLDGPVAGFLRQQQPAQAEAALEAALAAPQAPATGSVVLVGAGPGDPGLLTLKALRALNEADVILHDRLVSDEVMGLARRDAERVSVGKLPGENHNATQARIHKLMVEHARAGRRVVRLKGGDAFIFGRGGEELEYLRAHGVRYEVVPGITAALACAAYAGIPLTHREHAQSVRLVTAHCREDEDNLDWPALAREKQTLAFYMGVGQLDLLTNRLLAHGRSPDTPFALIENGSRPEQRVLSGTLERLPSLAAEHAIQSPALLIVGEVAGLAPQLQWFSQHIEGQPEEVAA
>LR134361.1|VEG66776.1|1457308_1457893_-|Probable-transcriptional-regulatory-protein-pdtaR
MLKVMLLNDGEGRAASLRQTLAAAGVHVVAEATPGMDLAAAIAQAAPDVVLIDSDAPGRDTLENVCVASEHSDRPVVMFTDNGNRDTIRSALRAGVAAYVVGDVPAGRIEPLLTVAIERFAMEKSRREELREAQLRLADRQWVEKAKGILMKARSISEDEAHGLLRQRAMQSQKRLGEVAREVVEMNAWLGKST
>LR134361.1|VEG66777.1|1458287_1459589_+|Nitrate-transport-protein-NrtA-precursor
MTPSTRSPSTDAAAGGDLSANAGRRKWLSGTARAVAGASLLSLVDPLVRAGAWAAGTDAPEKTEVKIGFIPLTDCASVVMASVLGIDKKHGVTITPSKEASWAAVRDKLMNGELDMAHVLYGLVYGVHLGIGGPKKDMAVLMSLNQNGQAITLSDKLRVAGVRDGESLAKLMASDKREYTFAQTFPTGTHAMWLYYWLASYGINPMKDAKVITVPPPQMVANMRVGNMDGYCVGEPWGARAILDNIGYTAVTSQGIWTDHPEKVLGTSADFVSRHPNTARAVTAAILEAGRWIDASPANRQKTAETIAAKSYVNTDASGIVDRMLGRYEDGLGKRWTDEHAMRFYADGSANFPYLSDGMWFLTQHKRWGLLKEHPDYLAIAKQINRIDLYKQAAQAAGVALPPSEMRSSKLIDGVVWDGSNPAGYADGFKVRA
>LR134361.1|VEG66778.1|1459623_1460454_+|Bicarbonate-transport-system-permease-protein-CmpB
MSTVTSMNRGDAFIVFWRERLECALRAVVGPVAGFALFVLVWQVVAMRIPEIPTPGVTWRAAVELFSDPFYDNGPNDKGIGWNLLASLQRVAIGFGLAALIGIPVGFAIGRYAAVRAMFSPIVSLLRPVSPLAWLPLGLLLFKAANPAAIWAIFICSIWPMIINTAVGVSRVPQDYLNVARVLNLSEWKVTTKVLLPAVLPYMLTGVRLSIGTAWLVIVAAEMLTGGTGIGFWLWDEWNNLKVEHIVIAIFVIGIVGLLLETLLVALARRFTYTEE
>LR134361.1|VEG66779.1|1460458_1461334_+|Bicarbonate-transport-ATP-binding-protein-CmpD
MKKHVRIERVGQTFNTRKGNFVALRDVDLTVDQGEFITLIGHSGCGKSTLLNLIAGLARPSSGVLLCAEREITGPGPDRAVVFQNHSLLPWLSCFQNVHLAVERVFGASEKRAQLIERTRAALDLVGLLPAQSKLPREISGGMKQRVGIARALAIEPGVLLMDEPFGALDALTRAHLQDELLKIVAKTRTTTIMVTHDVDEAVLLSDRIVMLTNGPAATIGEILPVPLPRPRDRVRLANDAAYLACRASVVDFLHRRHGNPERSQAAAQANAALSAADEPLAEAGASRAAA
>LR134361.1|VEG66780.1|1461341_1462562_+|Rubredoxin-NAD(+)-reductase
MDTKQKLVVVGNGMAGMRTLEELLKLAPDLYDITVFGAEPYPNYNRILLSPVLTGEQTLRDIVLNDEDWYVRHGIRLLLNRKVVGVNRARRIALADDGTEAPYDRLLLATGSNPFILPVPGSNLDGVIAFRDIGDVNRMIEASSRYRHAVVIGGGLLGLEAANGLAARGMDVSVVHLGESLLDRQLDGGAAALLRRSLEARGLKFLLGRQTREILDGGSGRVRALRFADGEEIPADLVVMAVGVRPNTELAERCGLHVNRGVVVSDTLQTYDPRIYAVGECVSHRGTAYGLVAPLYEQAKVAANHLALHGIGRYQGSVTATRLKVTGIDLFSAGDFTGGPQTEAITLADTPGGVYKKLVIRDDKLVGACLYGDTADSGWYVRLIREGRRIGPLRERLMHGEGAAGE
>LR134361.1|VEG66781.1|1462565_1465292_+|Nitrate-reductase
MDGSKTRRIDIVDVAHGVSEVASVCCYCGTGCGLRVQTRDGAVLRVRGDEQHPANRGRLCSKGLALADTVRRDGARVLSAQWRETRAQPMRAIALGEALDIVAARLADTIARDGPDAVGFYLSGQLLTEDYAVFNKLARGLVGTNNIDTNSRLCMSSAVSGYKRTLGADAPPACYEDLDLADTVLIAGSNMAYAHPVLFRRLEAARARRPGMKVIVADPRRTDTAAFADLHLPLAAGTDVALFHAMLNVMEREGLLDHGYIQRHTQGFETLMARARKITPRAAQDICGVPAEDIIRAARWFGGAGAALSLYTMGLNQSTSGTDKNAALIHLHLATGQIGKPGAGPFSLTGQPNAMGGREAGGMATLLPGHRDPGSAADREETAALWGVHALPHAPGATALEMFDAALQGRIKVLWIAATNPAQSLPDQARVRAALERAEFVIVQEAFAGTETLAYADLVLPAATWPEKSGTVTNSERRISRVRAAIDPPGDAQPDWRLAQAVALRLAARIAPDKAALFAYREESEVFAEHARTTAGRDLDYSALDYATLDAQGPQQWPYRQGQGTARLYADAVFPTASGRARFCDVDYQQVAEPTTPAYPLRLTTGRLRDHWHTMARTSLAPALTQHVEEPWVSMHAEDMRQLKLEPGALARLASRRGSVVLPVQADDALPSGQVFLPMHWGSAYMAGQGVNALTSPAADPISRQPELKHCAIRAEPAGLAWQAAGWLQGDSAALRARLAPWLRRFEYAVVLPVGAGGVRMRLAARAAPQAAELEAIAGALDLLAPDVAFDDPARGQMRRVRMEQGVLRGFLLAGDLRPQDALLAWAGGGDAPAGVAALLLGRIAGAARSRAICVCNGVSEAAILAGIGRGCDLAALKASLGCGTGCGSCVPEIQALIGRAALAAAPV
>LR134361.1|VEG66782.1|1465431_1466157_+|Uncharacterised-protein
MRKMASLVFLAGALGAAAAAQAGVCDAQFMHDGGAVQLTGSGNLALGADLTFAEVTKSNGDNCRARVQGVATFSYAGLPPGKSKLDYLMTVKGGQATFLRYASAGEAPKPSEGQFDLRMLGLFAYDGKLSAGQKLPGSSFRLKIGKEAPVGGQPSTTVRIGEKTVGQKTSVNTALGAQSCHPITYTRNSDPTMATFQGLTIPIPGMNTTVTDWYCPAINLVMKQDIDQGGVKSAVEITQIK

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Crispr_ID: LR134361_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134361_5

2129655-2129763

Orphan

Consensus_repeat	Method
GGACCGCACCAAGGCGGGGCAGCCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of LR134361_5

>merge|LR134361|5|2129655-2129763|CRISPRCasFinder
GGACCGCACCAAGGCGGGGCAGCCCCCTCGGGGGGCAGCAAGCAAGCGCAGCTTGCGCGGCGTGGGGGCCCGGCCCACCGCCGGACCGCTCCAAGGCGGGGCAGCCCCC

>LR134361|5|4|2129655-2129763|CRISPRCasFinder
GGACCGCACCAAGGCGGGGCAGCCCCC	TCGGGGGGCAGCAAGCAAGCGCAGCTTGCGCGGCGTGGGGGCCCGGCCCACCGCC
GGACCGCTCCAAGGCGGGGCAGCCCCC

Protein	Signature genes	Signature genes Name	Protein_function
LR134361.1\|VEG67394.1\|2125208_2126357_-\|Acyl-CoA-dehydrogenase-fadE12	unknown	unknown	gnl\|CDD\|173841
LR134361.1\|VEG67399.1\|2130647_2131499_+\|4-chlorobenzoyl-coenzyme-A-dehalogenase-2	unknown	unknown	gnl\|CDD\|236220
LR134361.1\|VEG67397.1\|2128451_2129633_+\|Beta-ketothiolase-BktB	unknown	unknown	gnl\|CDD\|181625
LR134361.1\|VEG67402.1\|2134591_2135779_+\|Acyl-CoA-dehydrogenase-fadE12	unknown	unknown	gnl\|CDD\|173841
LR134361.1\|VEG67400.1\|2131495_2133580_+\|Uncharacterized-conserved-protein	unknown	unknown	gnl\|CDD\|223972
LR134361.1\|VEG67398.1\|2129764_2130535_-\|Acetate-operon-repressor	unknown	unknown	gnl\|CDD\|224332
LR134361.1\|VEG67401.1\|2133618_2134587_+\|Argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|270296
LR134361.1\|VEG67393.1\|2124192_2125197_-\|Crotonobetainyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|173838
LR134361.1\|VEG67388.1\|2119514_2120396_-\|Uncharacterised-protein	unknown	unknown	unknown
LR134361.1\|VEG67390.1\|2121478_2121919_-\|Hypoxic-response-protein-1	unknown	unknown	gnl\|CDD\|341391
LR134361.1\|VEG67403.1\|2135784_2136825_+\|putative-acyl-CoA-dehydrogenase	unknown	unknown	gnl\|CDD\|224871
LR134361.1\|VEG67406.1\|2138519_2139836_+\|Malonyl-CoA-decarboxylase-(MCD)	unknown	unknown	gnl\|CDD\|368376
LR134361.1\|VEG67389.1\|2120683_2121448_+\|Sulfite-exporter-TauE/SafE	unknown	unknown	gnl\|CDD\|376667
LR134361.1\|VEG67396.1\|2127610_2128408_+\|Probable-enoyl-CoA-hydratase-echA8	unknown	unknown	gnl\|CDD\|181723
LR134361.1\|VEG67395.1\|2126608_2127577_+\|Argininosuccinate-lyase	unknown	unknown	gnl\|CDD\|270234
LR134361.1\|VEG67407.1\|2139884_2140676_+\|Probable-enoyl-CoA-hydratase-echA8	unknown	unknown	gnl\|CDD\|119339
LR134361.1\|VEG67391.1\|2122000_2122906_-\|Hca-operon-transcriptional-activator	unknown	unknown	gnl\|CDD\|176106
LR134361.1\|VEG67405.1\|2137816_2138569_+\|Uncharacterized-HTH-type-transcriptional-regulator-ydfH	unknown	unknown	gnl\|CDD\|224715
LR134361.1\|VEG67404.1\|2136880_2137651_+\|spermidine-synthase	unknown	unknown	gnl\|CDD\|179854
LR134361.1\|VEG67392.1\|2122984_2124196_-\|Formyl-coenzyme-A-transferase	unknown	unknown	gnl\|CDD\|367110

Protein	Function_ID	Function_description	E-value
LR134361.1\|VEG67394.1\|2125208_2126357_-\|Acyl-CoA-dehydrogenase-fadE12	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	8.68578e-87
LR134361.1\|VEG67399.1\|2130647_2131499_+\|4-chlorobenzoyl-coenzyme-A-dehalogenase-2	gnl\|CDD\|236220	PRK08290, PRK08290, enoyl-CoA hydratase; Provisional.	1.71099e-139
LR134361.1\|VEG67397.1\|2128451_2129633_+\|Beta-ketothiolase-BktB	gnl\|CDD\|181625	PRK09051, PRK09051, beta-ketothiolase BktB.	0
LR134361.1\|VEG67402.1\|2134591_2135779_+\|Acyl-CoA-dehydrogenase-fadE12	gnl\|CDD\|173841	cd01152, ACAD_fadE6_17_26, Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26. Putative acyl-CoA dehydrogenases (ACAD). Mitochondrial acyl-CoA dehydrogenases (ACAD) catalyze the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. The ACD family includes the eukaryotic beta-oxidation, as well as amino acid catabolism enzymes. These enzymes share high sequence similarity, but differ in their substrate specificities. The mitochondrial ACD's are generally homotetramers and have an active site glutamate at a conserved position.	1.55045e-135
LR134361.1\|VEG67400.1\|2131495_2133580_+\|Uncharacterized-conserved-protein	gnl\|CDD\|223972	COG1042, COG1042, Acyl-CoA synthetase (NDP forming) [Energy production and conversion].	2.24237e-119
LR134361.1\|VEG67398.1\|2129764_2130535_-\|Acetate-operon-repressor	gnl\|CDD\|224332	COG1414, IclR, Transcriptional regulator [Transcription].	8.65119e-41
LR134361.1\|VEG67401.1\|2133618_2134587_+\|Argininosuccinate-lyase	gnl\|CDD\|270296	cd13578, PBP2_Bug27, Aromatic solutes transporter of Bug (Bordetella uptake gene) protein family; contains the type 2 periplasmic binding fold. Bug27 binds non-carboxylated solute nicotinamide, in contrast to BugD (aspartic acid transporter) and BugE (glutamate transporter) which both bind aliphatic carboxylated ligands. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) receptors present in a number of bacterial species, but mainly in proteobacteria. Bug proteins are the PBP components of the tripartite carboxylate transporters (TTT). Their expansive expansion in proteobacteria indicates a large functional diversity.	8.78552e-150
LR134361.1\|VEG67393.1\|2124192_2125197_-\|Crotonobetainyl-CoA-dehydrogenase	gnl\|CDD\|173838	cd00567, ACAD, Acyl-CoA dehydrogenase. Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC).	1.50534e-18
LR134361.1\|VEG67389.1\|2120683_2121448_+\|Sulfite-exporter-TauE/SafE	gnl\|CDD\|376667	pfam01925, TauE, Sulfite exporter TauE/SafE. This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.	0.0015028
LR134361.1\|VEG67390.1\|2121478_2121919_-\|Hypoxic-response-protein-1	gnl\|CDD\|341391	cd04623, CBS_pair_bac_euk, Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria and eukaryotes. The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).	4.06528e-55
LR134361.1\|VEG67403.1\|2135784_2136825_+\|putative-acyl-CoA-dehydrogenase	gnl\|CDD\|224871	COG1960, CaiA, Acyl-CoA dehydrogenases [Lipid metabolism].	2.61125e-18
LR134361.1\|VEG67406.1\|2138519_2139836_+\|Malonyl-CoA-decarboxylase-(MCD)	gnl\|CDD\|368376	pfam05292, MCD, Malonyl-CoA decarboxylase C-terminal domain. This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidized. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK).	1.55006e-134
LR134361.1\|VEG67392.1\|2122984_2124196_-\|Formyl-coenzyme-A-transferase	gnl\|CDD\|367110	pfam02515, CoA_transf_3, CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	6.85003e-163
LR134361.1\|VEG67396.1\|2127610_2128408_+\|Probable-enoyl-CoA-hydratase-echA8	gnl\|CDD\|181723	PRK09245, PRK09245, crotonase/enoyl-CoA hydratase family protein.	2.2328e-144
LR134361.1\|VEG67395.1\|2126608_2127577_+\|Argininosuccinate-lyase	gnl\|CDD\|270234	cd07012, PBP2_Bug_TTT, Bug (Bordetella uptake gene) protein family of periplasmic solute-binding receptors; contains the type 2 periplasmic binding fold. The Bug (Bordetella uptake gene) protein family is a large family of periplasmic solute-binding (PBP) proteins present in a number of bacterial species, but mainly in proteobacteria. In eubacteria, at least three families of periplasmic binding-protein dependent transporters are known: the ATP-binding cassette (ABC) transporters, the tripartite ATP-independent periplasmic transporters, and the tripartite tricarboxylate transporters (TTT). Bug proteins are the PBP components of the TTT. Their expansive expansion in proteobacteria indicates a large functional diversity. The best studied examples are Bordetella pertussis BugD, which is an aspartic acid transporter, and BugE, which is glutamate transporter.	4.37626e-124
LR134361.1\|VEG67407.1\|2139884_2140676_+\|Probable-enoyl-CoA-hydratase-echA8	gnl\|CDD\|119339	cd06558, crotonase-like, Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.	5.60778e-56
LR134361.1\|VEG67404.1\|2136880_2137651_+\|spermidine-synthase	gnl\|CDD\|179854	PRK04457, PRK04457, polyamine aminopropyltransferase.	6.58949e-53
LR134361.1\|VEG67405.1\|2137816_2138569_+\|Uncharacterized-HTH-type-transcriptional-regulator-ydfH	gnl\|CDD\|224715	COG1802, GntR, Transcriptional regulators [Transcription].	2.23784e-40
LR134361.1\|VEG67391.1\|2122000_2122906_-\|Hca-operon-transcriptional-activator	gnl\|CDD\|176106	cd08414, PBP2_LTTR_aromatics_like, The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold. This CD includes the C-terminal substrate binding domain of LTTRs involved in degradation of aromatic compounds, such as CbnR, BenM, CatM, ClcR and TfdR, as well as that of other transcriptional regulators clustered together in phylogenetic trees, including XapR, HcaR, MprR, IlvR, BudR, AlsR, LysR, and OccR. The structural topology of this substrate-binding domain is most similar to that of the type 2 periplasmic binding proteins (PBP2), which are responsible for the uptake of a variety of substrates such as phosphate, sulfate, polysaccharides, lysine/arginine/ornithine, and histidine. The PBP2 bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. After binding their specific ligand with high affinity, they can interact with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase domains. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. Besides transport proteins, the PBP2 superfamily includes the substrate-binding domains from ionotropic glutamate receptors, LysR-like transcriptional regulators, and unorthodox sensor proteins involved in signal transduction.	5.39213e-64

>LR134361.1|VEG67397.1|2128451_2129633_+|Beta-ketothiolase-BktB
MNEVIVASAVRTAIGDFGGALKDVPPCDLGATVIKAALERAAVKGDEVGHVAVGHVINTEPRDMYLSRVAAMNAGIAKETPAFNVNRLCGSGLQAIVSAAQTIMLGDAEIAVGAGAESMSRAPYIAPAQRWGARMGDSVMLDMMTGALSDPFGRMHMGVTAENVAAKFGISRQDQDAVAAESHRRAAAAIDAGYFRDQIVPVVLKSRKGEVVFDTDEHVRRDVTADSLAGLKPVFQKENGTVTAGNASGLNDGAGAVVLMNASVAAKRGVKPLARLVAYAHAGVDPQIMGIGPVPATQAALKRAGLTVDQLDVIEANEAFAAQACAVSRELKLDPAKVNPNGSGIGLGHPIGATGAIITVKALHELQRVGGRYALVTMCIGGGQGIAAIFERI
>LR134361.1|VEG67396.1|2127610_2128408_+|Probable-enoyl-CoA-hydratase-echA8
MTDLVQYQQNADGVVILTLNDPKTRNALTGSTMVDELLSAFARIERDPDARVLVITAAGPVFSSGGNVNDMQRQIGPEVGSAALRQEYRHGIQRLPLALHALEVPTIAAVNGPAIGAGCDLACMCDVRIAAEEATFAESFVKLGIVPGDGGAWFLPRLIGMARAAEMSFTGDAIDARTAAEWGLVSRVVPAAELLPTAQALAARMAKNSPDAVRLTKRLLRESQHLRLDSLLELSAAYQALAHKTPAHARAVEDFVARRAARKPG
>LR134361.1|VEG67395.1|2126608_2127577_+|Argininosuccinate-lyase
MNKLMRMLALACAAWLALPAGAARAAYPDKPIRLIVSFPPGSGTDSNARYVAKKMEERLGVAVTVENRPGGNSFIAAQAVAAADPDGYTLLLASNSPVATNAAMFKHLPYDPVKDFAPVARLGYGAMALAVKADAPYKTVADLVNAARQRPGELNFGSGSASYQIATELFLSMGGIKANHVPYRGAAPALTDLAGGQVDFVFADYGAVIPFVQSGRMRLLAVTGDTRLKSAPDTPTLQESGFPGYYMVNWTAAFAPARTPAAIIDTLSDTLVSIYRTPDAAEFLARTNWEVFPVGPKELGAFQREEIRKWDEAAQRAGIPKQ
>LR134361.1|VEG67394.1|2125208_2126357_-|Acyl-CoA-dehydrogenase-fadE12
MIDTLELTAIPPEDEALRVEVRSFLAETLDGLEPDERARSWMGFDAGFSRQLAERGWLGLTLPREHGGSARGHFARFVLSEELLGAGAPVSAHWIADRQSAPLILKYGTPAQQACYLPRICRAQAFFCIGMSEPGSGSDLASIRTRAQRSASGWLVNGSKIWTTNAHRSHYMIALVRTSGSAQDRHQGLSQLIIDLSLPGVTVRPIEDLAGDAHFSEVFFDNVELAEDALIGEEGAGWAQVNAELAFERSGPERLYSSMALLECWLAHCRGLDDNASNRETLGSLLTQMAVLRAMSLSVAGKLAAGRSPATEAALVKDLGTELEQAIPRLIGDALGRRPDQPAPLPLLRTLAYLEQVAPTFSLRGGTREILRGIIARGLGLR
>LR134361.1|VEG67393.1|2124192_2125197_-|Crotonobetainyl-CoA-dehydrogenase
MDNLLGDAAERLYAQTCTPDLIRLAEQGHAPVEAWQACEEAGFGDALVPAEHGGAGLSLPEALPVVLAAGRHACPYPIADTMLARAWLCLARRPQTAGSIAIAAHGLAIQGARIGGLNLPWIRTADHVLAEAGGQAWLLPTRAACIRPSGVHGSLAAEASWALSDAERIEHGPSLAPLAAAAYAGLIAGAMERVLAMTLDYANQRSQFGKPIGRFQAVQQQISVMAEQACAARMAAQLAFQGSDALPGPLLAALGKARASQAVPQVADIAHAVHGAIGVTEECDLQLYTRRLREWRLAGGSESYWHERIGAAALAHGSDALTYLRVALCDKESA
>LR134361.1|VEG67392.1|2122984_2124196_-|Formyl-coenzyme-A-transferase
MNANPRDDLPLAGIRVLDLSRVLAGPWCTQTLADLGAEVWKIEAPGQGDDTRSWSPPDIDGESTYFLCANRSKESVAINLKHPEGQRIVRDLARQADVLVENYRLGALEAFGLGYEDLAAINPGLIYCSITGYGRSGPRAAEPGYDFVIQAESGLMSITGESDGAPMKLGVAITDLITGMNGVQAILAALLARARSGRGQHIDLALLDGAISVLANVGAGYLAAGHKPQRLGNAHPTVVPYQIFATRDGSFALAVGNDAQFSRLCALLNRPEWSTHPDYATSRARVLNRATLIPQLESLFAAEDTAHWLARVRAAGIPAGAVRSVDQALDAPELAARGMIADTPDAKHGTVRLLRSPLHLRGTPPREPAAPPRLGEHTDAVLARALALDEEARAALRSQGAIA
>LR134361.1|VEG67391.1|2122000_2122906_-|Hca-operon-transcriptional-activator
MDFRHLQQFLVLAETLNFHRAAEKLHMSQPPLSVSIRKLEEMVGVPLFQRGRQGVKLTEAGLAALDEARRALFHAEQFRQAARAGAAGEGGTVRIGFVGSATHGVLPRILPAFRQRYPGVTVVLREATSIRIMQELEEDTLEVGIVRVPVAMGSNVRLAPLTTENFALAVPKSHPLARRGRIRLADLADEAFIMYTATEAAGLRMAAINACQLRGFTPRITQEAVQVQTLLSLVESGLGVALVPAGGRRHPGTSVVYKTLTDFPADASIGISLAWNPATERSATRNLREMASQAFRDKGAK
>LR134361.1|VEG67390.1|2121478_2121919_-|Hypoxic-response-protein-1
MKTVAEILREKANQSVVTVSPDASVFEAVRIMAERSIGAVVVVQGDEVLGMLTERDYARKIVLQDRSSRTTKVRDIMTDSVYYVGRSDTREHCMAMMTERHFRHLPVIEDGKLIGLLSIGDLVKDVMSEQKFIIHELERYITGERG
>LR134361.1|VEG67389.1|2120683_2121448_+|Sulfite-exporter-TauE/SafE
MSISQYLLFLACVALATYAQTMTGFAFGLVLLGLSGVFQLASVSEVANVVSVLSLVNAAVTLARAKPQVNWSLMRPAMASSLVGVGAGVAALAWISGSMSVLLQLLLGCTILGCAVLLVARAQPLARVSSRGSFVFFGAVSGVLGGLFSSAGPPMVYHLYRQPLPLAAIRNSLLILFSLNAVVRLALVTGQGAFMASSFWLSLLALPVVIGVTWVARRYSTAGSMKTVKRMVFVLLLAAGLGLIVPAFKVLAGS
>LR134361.1|VEG67388.1|2119514_2120396_-|Uncharacterised-protein
MTPKQTTINTVTLTCSTCGSAQFTKLDTNEYRCSHCHAVTLVEDNVAQRLEKILRGMQQPAPAPQLGPRAIAAVALAVAAVIAIPLVASLLGSKPAATRLPPAPPPIDASLVKLTDIQEIRVRDRTQLVMIMRNETGKKIDVPRVTASFFQGELSLPSNSGSAPARSLQPGEYTPITISTPSQAYSRYTLQVSQPTLARGKNNDVAASKVQLVRNDGAYRLVGLLKNNGANAANSSQVTVMLYGEDGKLIGIGNGYGAASPLAPNALTSFDVRCEMLAEGRVASYDYMVQSEN
>LR134361.1|VEG67398.1|2129764_2130535_-|Acetate-operon-repressor
MNNSSPTGGTQSMRRALGLLRVLAQHQEEGIDLQGVMAEAGLERSTAHRLLSCLLEEQFAERDAKTRRYRLGVDSMQLGFAALRRTPLLDALRPFAQKLARLSGDTVFLVIRQGDYALCLLREAGSFPVKVFTIDQGERRLLGVGAGGLALMATLPDEEIAALYARHSASYAQIGASSAALMKSVRQARAAGYSEIVDTITPGVSGVGAAFRVSELTWVAFSFGAISSRLDAPRRAQMGALLRAECEAWARDYLGK
>LR134361.1|VEG67399.1|2130647_2131499_+|4-chlorobenzoyl-coenzyme-A-dehalogenase-2
MEYATLAVERHDSVCRISLARESARNAQSQQMLDELDDALTRAEQDDSVRVVVLAGRGAHFSAGHDLKEAQAKRADFTVEERWEYESRRYYGYCLRIWDFSKPTVAQVQGACVAGGFMIANMCDLVVCSDTAYFSDPVGHTLAAAATEVLIHPWVMGLRKAKEMLYTGEKVDAQEALRIGMVNRVVPEAELDAATLALAQRIAQAPPFGLRLIKRSLNRTADAQGFRTALSAHFDTHQLSHLSEEFQAVRERGLAQAIQRNKQLPEGASSAPGQAGGKRGDAA
>LR134361.1|VEG67400.1|2131495_2133580_+|Uncharacterized-conserved-protein
MTAFLDPLLNPRSIAMIGASANAGRIGGMPLDLLTRYGYPGGIYPVNPKYQEVFGRRCWPDIESVPEPVDLAVLAIAAADVTPMLRRCHARGVRAAIVYAAGFAEAGGEGARLQQELEAFAAESGMAVAGPNCMGFANLNTQAYTAFASVFKTAPAQTGPGKVSLLTQSGNVCAAVYAIARRLDLPFSHFINTGNEACLDFSQYLEYLAADPQTEIVLGYIEQLRDGERFKRACRELERQGKLLIALKAGTTDKGAQAVQSHTSALAGDRRVYGAAFRQLNVIEATDFAQMAHLASLATLRHRTAGKRVAVLTMSGALGAILADKFIGAGLDLPDLPPDLQAVLRGGIPDYGMVGNPVDVTGNVVNDPAFVHTVLEALATTDAIDAVVVYAPGYMLDRMADALTDVSRRHRRLFIAIDTGLAQSRAALREAEVAVFEDLGLAVAALAPYLLWCEARGAKRIAAAPELAKAVVPALPCNEADAREYVAAFGLPQARVSAAASADEAVAQARAAGYPVALKVLSADIAHKTEAGGVALNLADDEAVRRASGEVARAAAAAQPQARIDGVMVQKMERGVVEIIVGATRDPVFGPVLTVGLGGVLTELYQDTSHRLLPVDEDIALQMLRELKAFALLDGYRGKPRADVAAACRSIVAVGNALLAAPAHVAEIEVNPLLIKEEGQGVAVLDALILPATP
>LR134361.1|VEG67401.1|2133618_2134587_+|Argininosuccinate-lyase
MMKRLLAGVALACIGVTGTSMAQDNYPSRPIRIVVPFSPGGATDIMSRLLAEKLSGKLGQPVIVENKPGGGTMIASDYVSRAEPDGYTLLMAASSLGIAPSIYAKVNYDPIKDFAPISQVASVVHVLEVHPSVPAKNVGELIAYLKANPGKVSYGSVGTGSSTHLEAELFNSMAGVQMTHIPYKGSAPALNDLVAGRLQVMFDAWASSGPFVKDGKLRVLAVTTAQPSASVPDLPTVAASGLPGYSAMPWLGLVAPARTPQPVVDKIYSNLAQILQQPDVKAQFTGLGLDIIGSDPKTFAAFIRQDVSTWAKVARDSNIRLE
>LR134361.1|VEG67402.1|2134591_2135779_+|Acyl-CoA-dehydrogenase-fadE12
MTQLESDAREDQAFRLDLRGWLESAYARFAQDWPGGADPRNLDFRRAWEDTLCANGWSGLGWPKEHGGRALPLSRQAVFHEEHARCGAPLGVNLIGHGILAPTLLHFGTEAQKRRFLPGILSNREVWCQGYSEPGAGSDLASVRTRAQPAPGGYRLHGHKIWTSFADRAQWCFVLARTDAQAPKHKGLSFLLVDMRSPGVRVEPIRQITGEAEFCEVFFEDVFVPQDGLLGEPNQGWKIAMAAASFERGTYFIPRLVRFAQELNQVRELALRADAYGHVPASSATVRHQWARLAADSHVLALKSQRALAGAMRGDPPGPEGSSTKIHWSEAHQRLLELSLQLLGEDACLADGAPDARTAELTHAYLWSRAETILAGTSEIQRNIIAEQMLGLPKA
>LR134361.1|VEG67403.1|2135784_2136825_+|putative-acyl-CoA-dehydrogenase
MDLHPTEDQRMLEDAARRFLADRHPLGVARAAAGKPFEARLAQWREIAGQGWPALLAPPDQDGLGLGMREAWIVAEAAGRHLLSLPLAANMVLLPTLCAAGAAGQAAQWAGAVMAGDDYFADAAIRPDGSAFIEGAGAGVRALAAHRVGDAVVRLELHAPTPGAAGLDPTMPVARVVQPEVLDSVDLEVAPGTWERLRTRLRLLRSAELLGASSSALDMAAVHARERRQFDRAIGANQAIKHRLAEDWMALDDARLAGVAAVAAHDAGAASAGRDSLFAPLLAVEAGRRAAQNAIQVHGALGVTWECDAHLYLKRVLRLAAALQAEVSRAELLERIWEGGDGRKAA
>LR134361.1|VEG67404.1|2136880_2137651_+|spermidine-synthase
MHKSNFPSELDQPTLSEVDGVRYLHFNTVWVQGAMRIKNPSELVLEYTAQMMAWLLFLEPPKDEPIGMLGLGAGSLARFCVKHTRSPLLAVEWNPRVTAACHMFFRLPGSNRLDVEHADAGVWVADPLNAGHCPVLMVDLYDASAEGPVRDSVKFYRDCRRVLGEVGVLAVNLFGRHESFGKNIDNLSKAFDDRIVLLPEVEAGNQIVLAFSGPSLAITPAELLARAEVVEARYGLPARRWARSLTRHAVDGVLHF
>LR134361.1|VEG67405.1|2137816_2138569_+|Uncharacterized-HTH-type-transcriptional-regulator-ydfH
MTLPIVRQALYLEVADRLRGMIHARSLRNGEWIDELRLAGELGISRTPLREALKVLATEGLVRLEPRRGCFVNELSAQDLEDIFPLMAMLEGRCAFEAARKASDAQLAELEPLHAALAGHAKAGRIDAYYKTNYLIHEAVQALAGNQWLSDMVGNLRKVLSLSRHRSLSLPGRIQESCAEHLAIFEALKARDSDAAQALAHTHLMRQLEALRALSQADAADPAPSDPIVIEEPAHVRTRQSRTRARRTHA
>LR134361.1|VEG67406.1|2138519_2139836_+|Malonyl-CoA-decarboxylase-(MCD)
MSAPANLAPARGARTPEPEADAVDAVAAAESASLMSRLGKLWERGRLPSESEVRRLFEARLTDVAANKLARRWCEQYSAADGKDRRLMLTALAQARGGYAGDGGEGARLFKRFNAQPQGLRFLVELRADMLRWRKQVAGIQALDKDLEGLLSAWFDVGLLELRPLTWDSPASLLEKLILYEAVHEITSWDDLRRRVSPDRRCYAYFHPQMPGVPLIFVEVAFASQMADNVQVLLDSTLPPQDLDKARWAIFYSISNTQPGLKGISFGNFLLKRVVEQLLQELPKLKSFATLSPIPGFADWLGKLDAEAVEAIVREDKVRAKSRKREGVPDGHRWAARLSKAAQGKVSDVVKRAGLRLTANYLQSMKNGMPVDPVARFHLGNGARIERLNWAADTSSKGLKQSCGMMVNYLYDLDELDDNLARLGEGKPQVSRGVGRVA
>LR134361.1|VEG67407.1|2139884_2140676_+|Probable-enoyl-CoA-hydratase-echA8
MTDNVAGRVLLEREGDLAWVTLSHPGRLNAITVGMWRELRDVFDAIARDGALRCVIVRGEGGNFAAGADIREFPAQRADAAGVQHYHREVLAPALRAVAMCPHPVVAQIEGVCVGGGLEIASQCDLRIAGESARFGVPINRLGFPMAPDEMSGLLALVGRAATLAILLEGRVFGAAEARELGLLTRVVPDDQVAIAARRSAERIAAGAPLAARINKRLSRRLAAGGALTEDEYQDYFSYADSRDHKEGVRAFLAGVDPSFSGD

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Crispr_ID: LR134361_6

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134361_6

3064766-3064872

Orphan

Consensus_repeat	Method
CCCCCCGAAGCGCTAGCGCGCTTCCCCCC	CRISPRCasFinder

1 spacers

The CRISPR arrays of LR134361_6

>merge|LR134361|6|3064766-3064872|CRISPRCasFinder
CCCCCCGAAGCGCTAGCGCGCTTCCCCCCCAGGGGGGCATGCCTGCGGACCGGCGGAGCCGGATCCGCAAGGTGGGCTCCCCCCGAAGCGCTACCGCGCTTCCCCCC

>LR134361|6|5|3064766-3064872|CRISPRCasFinder
CCCCCCGAAGCGCTAGCGCGCTTCCCCCC	CAGGGGGGCATGCCTGCGGACCGGCGGAGCCGGATCCGCAAGGTGGGCT
CCCCCCGAAGCGCTACCGCGCTTCCCCCC

Protein	Signature genes	Signature genes Name	Protein_function
LR134361.1\|VEG68245.1\|3054390_3055374_-\|2-aminoethylphosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270264
LR134361.1\|VEG68259.1\|3070270_3071113_+\|Uncharacterized-conserved-protein	unknown	unknown	gnl\|CDD\|180100
LR134361.1\|VEG68255.1\|3065742_3067026_+\|Neu5Ac-permease	unknown	unknown	gnl\|CDD\|224509
LR134361.1\|VEG68253.1\|3063713_3064760_+\|Neu5Ac-binding-protein	unknown	unknown	gnl\|CDD\|270320
LR134361.1\|VEG68262.1\|3073468_3074458_+\|leucine/isoleucine/valine-transporter-permease-subunit	unknown	unknown	gnl\|CDD\|119323
LR134361.1\|VEG68248.1\|3058376_3059309_+\|Gcv-operon-activator	unknown	unknown	gnl\|CDD\|182990
LR134361.1\|VEG68254.1\|3065125_3065746_+\|TRAP-type-C4-dicarboxylate-transport-system,-small-permease-component	unknown	unknown	gnl\|CDD\|377284
LR134361.1\|VEG68256.1\|3067099_3067783_+\|Protein-of-uncharacterised-function-(DUF2848)	unknown	unknown	gnl\|CDD\|371339
LR134361.1\|VEG68258.1\|3069294_3070200_+\|HTH-type-transcriptional-regulator-YofA	unknown	unknown	gnl\|CDD\|223656
LR134361.1\|VEG68257.1\|3067867_3069217_+\|Glutamyl-tRNA(Gln)-amidotransferase-subunit-A	unknown	unknown	gnl\|CDD\|235921
LR134361.1\|VEG68263.1\|3074438_3075161_+\|Glutamine-transport-ATP-binding-protein-GlnQ	unknown	unknown	gnl\|CDD\|213186
LR134361.1\|VEG68251.1\|3061333_3062293_-\|Predicted-permease,-DMT-superfamily	unknown	unknown	gnl\|CDD\|223769
LR134361.1\|VEG68261.1\|3072615_3073467_+\|LIV-I-protein-H	unknown	unknown	gnl\|CDD\|119324
LR134361.1\|VEG68247.1\|3057056_3058133_-\|Spermidine/putrescine-import-ATP-binding-protein-PotA	unknown	unknown	gnl\|CDD\|226361
LR134361.1\|VEG68252.1\|3062383_3063289_+\|HTH-type-transcriptional-regulator-YofA	unknown	unknown	gnl\|CDD\|223656
LR134361.1\|VEG68260.1\|3071319_3072567_+\|Leucine-,-isoleucine-,-valine-,-threonine-,-and-alanine-binding-protein-precursor	unknown	unknown	gnl\|CDD\|380563
LR134361.1\|VEG68250.1\|3060045_3061236_-\|Putative-reductase-YPO4104/y4119/YP_4011	unknown	unknown	gnl\|CDD\|237460
LR134361.1\|VEG68246.1\|3055396_3057043_-\|Putrescine-transport-system-permease-protein-PotH	unknown	unknown	gnl\|CDD\|224099
LR134361.1\|VEG68244.1\|3053620_3054298_+\|Lipoprotein-releasing-system-ATP-binding-protein-LolD	unknown	unknown	gnl\|CDD\|226647
LR134361.1\|VEG68249.1\|3059322_3060036_+\|Phosphoserine-phosphatase	unknown	unknown	gnl\|CDD\|319803

Protein	Function_ID	Function_description	E-value
LR134361.1\|VEG68245.1\|3054390_3055374_-\|2-aminoethylphosphonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270264	cd13546, PBP2_BitB, Substrate binding domain of a putative iron transporter BitB, a member of the type 2 periplasmic binding fold superfamily. The substrate domain of this group shows a high homology to the periplasmic component of ferric iron transporter (Fbp), but its biochemical characterization has not been performed. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.42786e-117
LR134361.1\|VEG68259.1\|3070270_3071113_+\|Uncharacterized-conserved-protein	gnl\|CDD\|180100	PRK05463, PRK05463, putative hydro-lyase.	0
LR134361.1\|VEG68255.1\|3065742_3067026_+\|Neu5Ac-permease	gnl\|CDD\|224509	COG1593, DctQ, TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism].	5.26727e-87
LR134361.1\|VEG68253.1\|3063713_3064760_+\|Neu5Ac-binding-protein	gnl\|CDD\|270320	cd13602, PBP2_TRAP_BpDctp6_7, Substrate-binding domain of a pyroglutamic acid binding DctP subfamily of the tripartite ATP-independent periplasmic transporters; contains the type 2 periplasmic binding protein fold. DctP6 and DctP7 groups of the TRAP transporters that involved in pyroglutamic acid transport. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	1.87145e-118
LR134361.1\|VEG68262.1\|3073468_3074458_+\|leucine/isoleucine/valine-transporter-permease-subunit	gnl\|CDD\|119323	cd06581, TM_PBP1_LivM_like, Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivM forms a heterodimer with another TM, LivH, to generate the transmembrane pore. LivH is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	3.41095e-64
LR134361.1\|VEG68248.1\|3058376_3059309_+\|Gcv-operon-activator	gnl\|CDD\|182990	PRK11139, PRK11139, DNA-binding transcriptional activator GcvA; Provisional.	5.25639e-79
LR134361.1\|VEG68254.1\|3065125_3065746_+\|TRAP-type-C4-dicarboxylate-transport-system,-small-permease-component	gnl\|CDD\|377284	pfam04290, DctQ, Tripartite ATP-independent periplasmic transporters, DctQ component. The function of the members of this family is unknown, but DctQ homologs are invariably found in the tripartite ATP-independent periplasmic transporters.	6.79471e-15
LR134361.1\|VEG68256.1\|3067099_3067783_+\|Protein-of-uncharacterised-function-(DUF2848)	gnl\|CDD\|371339	pfam11010, DUF2848, Protein of unknown function (DUF2848). This bacterial family of proteins has no known function.	2.2003e-89
LR134361.1\|VEG68258.1\|3069294_3070200_+\|HTH-type-transcriptional-regulator-YofA	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	1.01009e-42
LR134361.1\|VEG68257.1\|3067867_3069217_+\|Glutamyl-tRNA(Gln)-amidotransferase-subunit-A	gnl\|CDD\|235921	PRK07056, PRK07056, amidase; Provisional.	0
LR134361.1\|VEG68263.1\|3074438_3075161_+\|Glutamine-transport-ATP-binding-protein-GlnQ	gnl\|CDD\|213186	cd03219, ABC_Mj1267_LivG_branched, ATP-binding cassette component of branched chain amino acids transport system. The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).	1.5487e-103
LR134361.1\|VEG68251.1\|3061333_3062293_-\|Predicted-permease,-DMT-superfamily	gnl\|CDD\|223769	COG0697, RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only].	8.22035e-15
LR134361.1\|VEG68261.1\|3072615_3073467_+\|LIV-I-protein-H	gnl\|CDD\|119324	cd06582, TM_PBP1_LivH_like, Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of branched-chain amino acids (AAs). These types of transporters generally bind type 1 PBPs. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP, which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. E. coli LivH forms a heterodimer with another TM, LivM, to generate the transmembrane pore. LivM is not included in this subgroup. The LIV-1/LS transporter is comprised of two TMs (LivM and LivH), two ABCs (LivG and LivF), and one of two alternative PBPs, LivJ (LIV-BP) or LivK (LS-BP). In addition to transporting branched-chain AAs including leucine, isoleucine and valine, the E. coli LIV-1/LS transporter is involved in the uptake of the aromatic AA, phenylalanine.	1.00411e-70
LR134361.1\|VEG68247.1\|3057056_3058133_-\|Spermidine/putrescine-import-ATP-binding-protein-PotA	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	1.97433e-146
LR134361.1\|VEG68252.1\|3062383_3063289_+\|HTH-type-transcriptional-regulator-YofA	gnl\|CDD\|223656	COG0583, LysR, Transcriptional regulator [Transcription].	5.98707e-41
LR134361.1\|VEG68260.1\|3071319_3072567_+\|Leucine-,-isoleucine-,-valine-,-threonine-,-and-alanine-binding-protein-precursor	gnl\|CDD\|380563	cd06340, PBP1_ABC_ligand_binding-like, type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup includes the type 1 periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions. This subgroup has high sequence similarity to members of the family of hydrophobic amino acid transporters (HAAT), such as leucine-isoleucine-valine binding protein (LIVBP); however, their ligand specificity has not been determined experimentally.	2.3835e-145
LR134361.1\|VEG68250.1\|3060045_3061236_-\|Putative-reductase-YPO4104/y4119/YP_4011	gnl\|CDD\|237460	PRK13656, PRK13656, enoyl-[acyl-carrier-protein] reductase FabV.	0
LR134361.1\|VEG68246.1\|3055396_3057043_-\|Putrescine-transport-system-permease-protein-PotH	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	6.76175e-85
LR134361.1\|VEG68244.1\|3053620_3054298_+\|Lipoprotein-releasing-system-ATP-binding-protein-LolD	gnl\|CDD\|226647	COG4181, COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism].	1.6701e-112
LR134361.1\|VEG68249.1\|3059322_3060036_+\|Phosphoserine-phosphatase	gnl\|CDD\|319803	cd07500, HAD_PSP, phosphoserine phosphatase (PSP), similar to Methanococcus Jannaschii PSP and Saccharomyces cerevisiae SER2p. This family includes Methanococcus jannaschii PSP, and Saccharomyces cerevisiae phosphoserine phosphatase SER2p, EC 3.1.3.3, which participates in a pathway whereby serine and glycine are synthesized from the glycolytic intermediate 3-phosphoglycerate; phosphoserine phosphatase catalyzes the hydrolysis of phospho-L-serine to L-serine and inorganic phosphate, the third reaction in this pathway. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.	1.76856e-82

>LR134361.1|VEG68253.1|3063713_3064760_+|Neu5Ac-binding-protein
MKKSLVFAAVAASLLAGAVQAQDLPKTHLKIVGGLSNLTAYNDYEKPFWTKTIPELSKGQVTADIKGFNEMGLKGPELLRLMSQGVVEFGTATLAYFASDNPINEAIDLAGLAPDVKTARAVTDAFEPVYAKLYGEGNNVKLLGISTYPAQVLFCNAEIKGLADIKGKKVRTSSRTTAEFVEALGGSSVTMAFGEVVPALQNKVVDCAITGSLSGYSAKWYEVSTHLVALPINWNQQIHAVNQKAWDKLDPKVRTFLQTNVKTLVDNIWDAAARQTQEGYDCNTGAAACPFPVKGKMVLVQPTDADRALLKKVTEESVLPKWAARCSAQCVKDFNATVGKTLGVVANK
>LR134361.1|VEG68252.1|3062383_3063289_+|HTH-type-transcriptional-regulator-YofA
MIELRNIETFFWVATLGSFRAASEKLNTTQPAVSQRIASLEADLGVRLFEREARGVKLTAKGHELLSHAERMLQVRRDMFEAAREQNVMSGTVRIGVAETIVQTWLPTLIELIHSNYPALVLEIEVDTTHVLRSHLMSRQIDLAFLMGPVLEARVENLPLCTYPLAWVASPVLDLGPEPLTLERIGKLPIITYPSNSAPYRVVRDMLTRAGVNSPRMYGSASMSMMVRMTQDAIGTSVIAPVFLGKELARGELRILRVEADPLPELSFTATWVQGPDSHAVRVIAQMAQKVAEQAADGIPL
>LR134361.1|VEG68251.1|3061333_3062293_-|Predicted-permease,-DMT-superfamily
MTPADNGRARPALPATSGPMMGVLLLVLSMWTLSCLDASGKWVMNAGVPLLVLSWFRYAVHLALVLALVLPARGLGVFRSRKPREQILRGGSMFLATLMFFTTLSYIPQAEATAINFLAPLLVLSAAPWVLKEPARLSRFVAAGIAFIGVIIVIRPGGGLDPVGTVFGLLTACCFAVQFIATRRVAGDDPFTSLIWSGAVGTICLTLALPFILPPALPVLKALAPLDWVVLISTGITGGLGHLFQIGAYRRAPASTLAPFVYLQIISATSVGWLVWGHFPDPLTWLGIAIICASGIGIGLIEWRRSRAQAAPLAGADAR
>LR134361.1|VEG68250.1|3060045_3061236_-|Putative-reductase-YPO4104/y4119/YP_4011
MIIKPRVRGFICVTTHPAGCAANVRNQIDYVKAQGPVADGPKRVLVLGASTGYGLAARITAAFGCGAQTVGVFFERPGDKAKAGTPGWYNTAEFHEQAHAAGLYAKSINGDAFSDEIKRKTIALIKQDLGQVDQVIYSLAAPRRTHPKTGEVFNSTLKPIGQAVNLRGLDTDREVVKESVLEPATQAEIDATVAVMGGEDWQMWIDALLEAGVLAEGATTTAFTYLGEKITHDIYWNGSIGAAKKDLDQKVLEIRAKLAARGGDARVSVLKAVVTQASSAIPMMPLYLSLLFKTMKEAGTHEGCIEQVYGLYRDSLCGKTPILDQDGRLRADYKELAPEVQARVMALWDQVTNDNIYQLTDFAGYKQDFLRLFGFEIDGVDYEADTDPAVEIRGLA
>LR134361.1|VEG68249.1|3059322_3060036_+|Phosphoserine-phosphatase
MHSASTIPGLQWRGIAPPLALTDYKLIAFDMDSTLISIETLDEMADLMGKKAEVAALTEAAMRGEIKDYKQSLRERVALLAGMPQAALDEVYEQRVRLNPGVETLIAACKAAGLTCLLVTGGFTCFTDRLRVRLGLDDVRANVLEVENGRLTGRLLPQPWGDICDGEEKRRKLLEVCASLGVGPERAIAVGDGANDLPMMRAAGLSVGYRAKPAVREEVKVAIDEGGLDRLLELMAR
>LR134361.1|VEG68248.1|3058376_3059309_+|Gcv-operon-activator
MAGQSLPPLKALRVFEAAARLRSFTAAADELSITHSAVSQQIRILEEYVGQPLFAREARGVALLPCAQAYFPEIQASLERIAAATAKLKSPAYGGVLRVCATPSLTMKWLIPRLSAFQERHPGVDVQLTTQGRSFLDRGGDTGSDVLIRHGYMAHSDLACVHCLDDFHVPVASPRFIERNRLAAPADCLGHPLLKIAGGMDHWPRWFALAKVDVPAQLPGPVFDHQFLCMQAAMNDLGIALAPWCLLDDDIRADRLRPLFDGPQLPNAGIHALYRQDSPAAPSAQLFIEWLREQGRGPSRDPASEFSQPG
>LR134361.1|VEG68247.1|3057056_3058133_-|Spermidine/putrescine-import-ATP-binding-protein-PotA
MASITIDGIVKTFGGQQVLRNLSLHIPDGAFYTLLGPSGCGKTTLLRCIAGFYAPDGGRLLFDQDDVTHVSAHRRDIGMVFQDYALFPDKTAFDNVAYGLRARGVARAEITRRVNEALDKVGLLSLAERYPAQMSGGQRQRVALARALVIRPRVLLMDEPLSNLDAKMRLQMRDVILDLVREAGITTVFVTHDQEEALAMSDRIAIMDRGDIAQLGTPEELYGTPVNAYVADFIGSANVIPVPARNGQAGAPAGHVRYEICGLGFDGVQGSDTLDGKGVLIARPEELALMAPAPYVPNTLPGKVLRRQYLGFKTAYRIALENGSEIRVELHAGNMVAQFQPGEAVQVLIPADSRVVNA
>LR134361.1|VEG68246.1|3055396_3057043_-|Putrescine-transport-system-permease-protein-PotH
MKIKWWPWGILTAISLALLLFFVLYPLGVLFGNSVTGQDGGFSLEGFKALLADSQYLEAFGNTLILGLAVTTCTVLVGVPFAYMVARFDFPLKNLVAILPVLTIVIPEIIVGQSWLLILGNNGILTNLLGDAGISLPSFYGWTGMVFSMTLVYYTYIYLGVLAALRGFDGQLEEAGLSLGTPPLLTKLRVLVPVLLPAVLVNALVVFTLVVGNFALAMLLGSRVPLLSVMTYNTFVSEMGGSPTLQSAMSVVSIAIVAIVLFFQKRVVERKVYTMTQGRAPAATRVRSWTALLYTSGVGLIIFISLLPLIVVFIAAFTKTSGPVMQWGQWSLASMQRALHGAPEPILNSLKFASLATVLGVSFAVLVSYLTIKKRTASTQVLDYIVVLPLTISGTVLGIALVQTFNTGWLVLAGTSGIMVLCYTVRRLPFAVRNASSVLFNIPESIEEASISLGVSPLMTFFKVILPAMKASIISAAILMWLTTISELSASIVAYSGGLETMPIAIFRQVDGGRLGMASAYGAALVTVIVLPIIVSVKAFRIKLFSGK
>LR134361.1|VEG68245.1|3054390_3055374_-|2-aminoethylphosphonate-ABC-transporter-substrate-binding-protein
MQLKHLLQYSVLSAALATGAAQAQNVVLYSSNNTETIETALDAVKQKSPKLNVQPVTGGTGTMMKRIEAEAQNPRGDLFWSGGFGTLGAYRQHLQPYRPVDLDKIPAEFRGPDDLWVGTNVHVMVMMVNERQLKGLAAPATWSDLMQPQWKNKFAITDPSKSGTAYMLVYGLYKQFGQEGLDKIAANAVVTASSGTTYKGVAAGEYAVGMTLEYAAQEYVAGGQKEIKLVYPTEGSYLAPEGMFIIKGAKNMDAAKALYDGLLSKESQEAQLVKNFRRPTRTDVAVANLTTLPDLKSIKIFPVSQDAAAKEYEAVVSAWNQAVAKGK
>LR134361.1|VEG68244.1|3053620_3054298_+|Lipoprotein-releasing-system-ATP-binding-protein-LolD
MDSKNSIEVKGLGKQVADAGGTLSILEGIDFTVEAGSAVAITGSSGSGKSTLLGLLAGLDVPSAGSVRLAGQDLFALDEDGRARLRANHVGFVFQSFQLLPNLTALENVMLPLELAGQSARDAAQAMLERVGLGKRLHHYPRTLSGGEQQRVSLARAFVVQPDLLFADEPTGSLDAATGVTVIDLMFDLHREHGTTLVLVTHDPQLAARCGRQLVLAAGRLTNGA
>LR134361.1|VEG68254.1|3065125_3065746_+|TRAP-type-C4-dicarboxylate-transport-system,-small-permease-component
MTQSEHFRLLGGLLRRAESFSRLAVWAGGGLTVASVLLISFDVLARKFLGFTTGGADELSSYAFAISTSWALAFATLQRANVRVDVVYQYMPVRIAAVLDWISMVALSVFMVYLTYYAFEVVQTSWAQKSAANTPLATPLWIPQGLWALGLAWMCVTVALMLARASAALVTGDVELVKSICGVRSAQEEADEEAAAGERMVKGETA
>LR134361.1|VEG68255.1|3065742_3067026_+|Neu5Ac-permease
MISTALILLLVLIGLSIPVGAALGVLGLILDPLFSMLPLTRAIGEVSWSTNNEFLLVAIPLFIMLGEVLLRAGFAERMYGAMSLWLSWLPGGLMHANIGASTLFSATSGSSVATAATVGTVAIPQIRKYGYNEPLFLGSLAAGGTLGILIPPSINLVIYGVLTNSSVPKLYLAGIIPGFAMAALFMLTVVIACVAKPSWGGKKIQATWGQRMASLVHLAPPMGIFFLVVGSIYAGLATPTEAAALGVLGAFILAAWFRRLSWSMLREVMEGTMRSTAMIMLIVVAASFLNFVMSATGLTDALTKSITGLGLSPGWMLLIVVIFYLVLGCFMETLSMMITTIPIVAPIMIGLGFDPIWLGIVIIILVEAALITPPVGLNLFVVQSLRKSGSMSAVIVGSLPFVAAMFVMLALLAFWPDVALWLPRVFG
>LR134361.1|VEG68256.1|3067099_3067783_+|Protein-of-uncharacterised-function-(DUF2848)
MKAVFQIEDSQPRQVEVEFDTLIVAGWAGRDIAAIEHHIEELAAIGVPRPSSVPLYYRIADNQLTQKETVQALGEESSGEVETFVFSVDGEMYVSIASDHTDRKLETYSVAMSKQVCVKPLAGSAWRLADVADYWDELIIRSYIVENGVEVLYQEGPLASLRTPQDLVAGYTGGAAVLPAGAGMTCGTVGAIGGIRPSVDFTMELHDPRRQRTLRHRYHVETLPVVA
>LR134361.1|VEG68257.1|3067867_3069217_+|Glutamyl-tRNA(Gln)-amidotransferase-subunit-A
MVSTLNDLTLALQEGRSSSVELTQAALARAQDDAGEGARAFTRLYAESALAQAQASDTLRAAGIVRSAIDGLPISIKDLFDVEGETTMAGSVAREGEPAADADAEVVRRLVAAGAVIIGRTNMTEFAYSGLGINPHYGTPLNPYDRATGRIPGGSSSGAAVSVSDGMAVAAIGSDTGGSVRIPAALCGLTGFKPSAWRVSMEGVLPLSANLDSIGPIAASVRCCAELDAILSGDGGPVPEAAVLRGLRLAIPTTLALDAMDKHVADSFAAAVARLKTAGAQIDEIPIPEFAELAAINAKGGFTAAEAWAWHRDLIARAGKRYDPRVVSRIMRGKDMSAADYLDLLDAREAWVAAVDRRIAGYDALIMPTTPIVAPAVADLQASDDAYYAANGLILRNPTLINFLDGCALSLPCHAPGTAPVGLMIAGSNGTDRRILGIGLAVEALYAGQ
>LR134361.1|VEG68258.1|3069294_3070200_+|HTH-type-transcriptional-regulator-YofA
MIDLRNIETFFWVATLGGFRAAAEKLNATQPAISQRIASLESDLGVRLFDRDTRGIKLTGKGRELLSHAERMLQMRRDMQEAARAKSVMSGMLRLGVSETIVHTWLPTLMEYLHDAYPALMVEIQVDTTTVLKTQLASRQIDLAFLLGPMEEPRIENLYLCNYPLSWVASPKLKVGRQPIPLKRLAEWPVITYPSTTDPHRAVRQLLQQAGVEAPRMYGSSALSVIVRMARDGIGTAVIAPVILHKELAQGELRILDVKAPALPPLHYTACWMQGPDSQIPRAVAEAAQQIAREEALRHPA
>LR134361.1|VEG68259.1|3070270_3071113_+|Uncharacterized-conserved-protein
MSPYLHHHQGDSMQTKPAARASVELARQARMDARSGKLTGPTANLAPGHVQANLAILPRALAADFLHFCQRNPKPCPLLAMSEPGDPALPELGYDIDIRTDIPRYRVWQNGELVAEPADVRDIWRDDLVSFLIGCSFSFEEAMLDNGLPVRHIEQGCNVPMYRTSIPTHAAGVFGGPLVVSMRPLKAADAIRAIQVTSRFPSVHGAPVHLGDPALIGIADINRPDYGDPVEIREGEMPVFWACGVTPQSVVAAVRPEFCITHAPGHMLVTDLINSRMAVF
>LR134361.1|VEG68260.1|3071319_3072567_+|Leucine-,-isoleucine-,-valine-,-threonine-,-and-alanine-binding-protein-precursor
MKMKLIAGVAASLALMSAVPAQAQQAVRIGAIYPLSGALASTGSEIKAAVELAVDIINNPHPELEGIPLAAGSGLPALGGAKIEVVFGDSQGKPEVGLADAQRLIDQEKVVALTGAYQSAVTKTASRIAEQRGIPYVNGESSSPDLTERGYKWFFRTSPNDDTFVENMMQFLDGVKAVPTAKIAVVYENTDFGVNTYKAVEKFAKQYKRQLVANIAYSAGSASVTAEVQKLAAAKPDVAIFASYTSDAMLFVRTMRESKYAPPVLLANDAGFIDSRFVQEVGPQVQGVLTRDVWGNDVAASKAGLKKINDMYKAKTGKDLNGNNARSMQGVLVLADAINRAGSTDPEAIRKALVATDLGEAQVAMPWAGVQFDAKGQNTKGSGLILELKGSAYQTVWPEKYRADKSLPTLPFTWK
>LR134361.1|VEG68261.1|3072615_3073467_+|LIV-I-protein-H
MFEALSAGLFNGLIYAAVAVGLALIWGITDVINFAHGEFLMLGMYAAYWLYTLGHIDPTLSAPLVAVALAFVGFLTYALIIRRLQKGPAMAVILATFGLGLVLRQIAFIAFSPDYRSLPDTLVSGSVTLAGISLGRPQVVTGLIALVVVVALFVLVYRTRWGHALQAVAEDRQVAALVGISPDRVNAQVWMLGSAAVGLAGALLTTFFYVFPSVGTVFGLLAFVAVCMGGFGSLPGAFIAGILIGIIEAMTGYFVAPALKTVSVFILFILVLWYRPRGLFGRW
>LR134361.1|VEG68262.1|3073468_3074458_+|leucine/isoleucine/valine-transporter-permease-subunit
MNTTRKLDAASAGVPKWPVAAAAVAAILMARVPLVVKDAFTLQVLLLAIMFGALGACWNLVGGFLGRISFGHSVFVGVGGYTTLLLLHHLKLTPLLGIPLGGLISAGLAWLVGGPTLRLSGHYFAMATIALLQIGLLLMINWEWAGGAVGLEAPIGDAAWMLLFRSKVPYYWIAVGLAFLTFCATFFLVHSKTGFYWRAINGDEAASRSLGVPADRYKMLAFVMSAGMTGVWGGFFAMYVGFIDPESMFNLTMSVQVVLVTILGGVGTLIGPWLGAAVLLPLSEGTRVLWGSSGMGLDLLVFGLAILLVTLFLPGGLVTLRRRRGSAGR
>LR134361.1|VEG68263.1|3074438_3075161_+|Glutamine-transport-ATP-binding-protein-GlnQ
MALLDVKNLTKQFGGLVANKDISLSVEAGEIVAIIGPNGAGKSTLFNGLVGHHEPTSGSVTFDGQSMIGRRPEQVAAMGLVRTYQIPRSFGQMTVLENAMVGALLRHPRLQDARRESARVLELVGLAERADVRAAELNVAGQKRVELARALATEPRMLLLDEVAGGLNPAEAIALAGILRGIHASGVTLIIVEHVLEVVMRLAQRVLVLNFGQMIAEGAPQEIVRDPAVIEAYLGRKHRA

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

3031628 : 3039862

Moraxella_phage(28.57%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VEG68222.1\|3031628_3032225_+	IMPACT family member yigZ	A0A1X9I5T8	Streptococcus_phage	3.2e-20	33.3
VEG68223.1\|3032337_3032712_-	Thioredoxin-1	V9SJ74	Achromobacter_phage	1.9e-10	27.8
VEG68224.1\|3032882_3033899_-	Limonene 1,2-monooxygenase	NA	NA	NA	NA
VEG68225.1\|3034109_3035402_-	Probable adenine permease PurP	A0A0R6PHV4	Moraxella_phage	4.3e-62	35.1
VEG68226.1\|3035510_3036542_+	t(6)A37 threonylcarbamoyladenosine biosynthesis protein	A0A0R6PI74	Moraxella_phage	4.9e-93	52.3
VEG68227.1\|3036592_3037234_-	G3P acyltransferase	NA	NA	NA	NA
VEG68228.1\|3037422_3038181_+	5'-nucleotidase surE	A0A1B1ITZ2	uncultured_Mediterranean_phage	6.4e-66	50.8
VEG68229.1\|3038165_3038990_+	Protein-L-isoaspartate O-methyltransferase	A0A1B1IU40	uncultured_Mediterranean_phage	1.1e-31	45.8
VEG68230.1\|3039007_3039862_+	Murein hydrolase activator NlpD precursor	A0A292GJG6	Xanthomonas_phage	1.4e-13	45.0

DBSCAN-SWA_2

5726311 : 5797577

Burkholderia_phage(24.24%)

terminase,portal,capsid,plate,integrase,tRNA,head,tail,lysis

attL 5720583:5720599|attR 5802013:5802029

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
5720583:5720599	attL	NA	NA	NA	NA
VEG72319.1\|5726311_5727361_-\|portal	phage portal protein, PBSX family	E5E3X1	Burkholderia_phage	3.6e-115	59.6
VEG72321.1\|5727357_5729136_-	Uncharacterized conserved protein	A4JWQ1	Burkholderia_virus	7.9e-224	65.7
VEG72323.1\|5729272_5730103_+\|capsid	Phage capsid scaffolding protein (GPO) serine peptidase	A0A1S5NPS0	Burkholderia_phage	3.2e-58	48.6
VEG72325.1\|5730132_5731173_+\|capsid	phage major capsid protein, P2 family	A0A077KEQ8	Ralstonia_phage	2.1e-99	53.4
VEG72327.1\|5731174_5731876_+\|terminase	Phage small terminase subunit	A0A2H4J948	uncultured_Caudovirales_phage	1.2e-34	39.9
VEG72329.1\|5731970_5732438_+\|head	Phage head completion protein (GPL)	E5E3S2	Burkholderia_phage	6.8e-34	50.0
VEG72331.1\|5732437_5732644_+	Phage Tail Protein X	E5G6M9	Salmonella_phage	5.8e-14	57.4
VEG72333.1\|5732650_5733022_+	Uncharacterised protein	NA	NA	NA	NA
VEG72335.1\|5733018_5733315_+	Protein of uncharacterised function (DUF754)	NA	NA	NA	NA
VEG72337.1\|5733307_5734114_+	Uncharacterized conserved protein	E5FFI0	Burkholderia_phage	3.2e-79	58.6
VEG72339.1\|5734110_5734539_+\|lysis	phage lysis regulatory protein, LysB family	NA	NA	NA	NA
VEG72341.1\|5734631_5735129_+\|tail	P2 phage tail completion protein R (GpR)	E5G6N3	Salmonella_phage	3.7e-22	40.6
VEG72344.1\|5735121_5735589_+	Mu-like prophage protein gpG	A0A2H4J927	uncultured_Caudovirales_phage	1.2e-33	49.0
VEG72346.1\|5735649_5736294_+\|plate	Phage P2 baseplate assembly protein gpV	A4PE41	Ralstonia_virus	5.0e-43	46.9
VEG72348.1\|5736290_5736644_+	Gene 25-like lysozyme	E5E3V5	Burkholderia_phage	8.5e-13	45.0
VEG72350.1\|5736648_5737569_+\|plate	Baseplate J-like protein	A0A077K9X9	Ralstonia_phage	4.3e-80	59.5
VEG72352.1\|5737565_5738189_+\|tail	Bacteriophage P2-related tail formation protein	A0A2H4JAU2	uncultured_Caudovirales_phage	6.5e-56	56.1
VEG72354.1\|5738185_5741137_+	Uncharacterised protein	A4PE45	Ralstonia_virus	1.3e-37	45.1
VEG72356.1\|5741143_5741593_+	Uncharacterised protein	NA	NA	NA	NA
VEG72358.1\|5741758_5742934_+\|tail	Phage tail sheath protein	A0A1S6KZY7	Salmonella_phage	4.1e-144	65.5
VEG72360.1\|5742985_5743501_+\|tail	phage major tail tube protein	Q9ZXK3	Pseudomonas_virus	4.2e-45	50.9
VEG72365.1\|5743540_5743900_+\|tail	Phage tail protein E	A4PE51	Ralstonia_virus	3.4e-17	55.3
VEG72367.1\|5744031_5747319_+\|tail	Phage-related minor tail protein	A0A2H4JE61	uncultured_Caudovirales_phage	3.5e-169	43.7
VEG72369.1\|5747331_5747787_+	Phage protein U	Q9ZXJ9	Pseudomonas_virus	3.3e-33	54.8
VEG72371.1\|5747786_5748827_+	Phage protein D	R4JDM6	Burkholderia_phage	6.3e-80	46.9
VEG72373.1\|5748776_5749157_-	Uncharacterised protein	NA	NA	NA	NA
VEG72375.1\|5749330_5749813_-	Uncharacterised protein	NA	NA	NA	NA
VEG72377.1\|5749822_5750227_-	Helix-turn-helix	E5E3P4	Burkholderia_phage	9.7e-13	53.9
VEG72379.1\|5750550_5750841_+	DNA-binding transcriptional regulator	E5E3P1	Burkholderia_phage	4.0e-08	39.5
VEG72381.1\|5750833_5751220_+	Uncharacterised protein	NA	NA	NA	NA
VEG72383.1\|5751303_5751537_+	Uncharacterised protein	NA	NA	NA	NA
VEG72385.1\|5751539_5754242_+	DNA primase (bacterial type)	A0A077K8T2	Ralstonia_phage	2.9e-270	52.9
VEG72387.1\|5754238_5754514_+	Uncharacterised protein	NA	NA	NA	NA
VEG72389.1\|5754510_5755428_+	Modification methylase HhaI	A0A291AUL2	Sinorhizobium_phage	4.8e-07	24.8
VEG72391.1\|5755424_5755688_+	Uncharacterised protein	NA	NA	NA	NA
VEG72393.1\|5755674_5756946_-\|integrase	Prophage CP4-57 integrase	B7SYF8	Stenotrophomonas_phage	3.0e-92	45.4
VEG72395.1\|5757357_5758911_-	SpoVR family protein	NA	NA	NA	NA
VEG72397.1\|5758907_5760167_-	Uncharacterized conserved protein	NA	NA	NA	NA
VEG72399.1\|5760179_5762105_-	PrkA family serine protein kinase	NA	NA	NA	NA
VEG72401.1\|5762968_5764174_+	Protein of uncharacterised function (DUF3142)	NA	NA	NA	NA
VEG72403.1\|5764160_5766623_+	Uncharacterised protein	NA	NA	NA	NA
VEG72405.1\|5766641_5767793_-	Riboflavin biosynthesis protein RibD	A0A1V0SE20	Indivirus	9.8e-42	33.6
VEG72407.1\|5767970_5768534_+	nicotinamidase/pyrazinamidase	NA	NA	NA	NA
VEG72409.1\|5768551_5769505_+	Uncharacterized HTH-type transcriptional regulator ypdC	NA	NA	NA	NA
VEG72411.1\|5769506_5769845_-	Transcriptional repressor NrdR	NA	NA	NA	NA
VEG72413.1\|5770190_5771441_-	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase 2	A0A219YCZ0	Aeromonas_phage	4.7e-98	51.9
VEG72415.1\|5771646_5772282_+	Homoserine/homoserine lactone efflux protein	NA	NA	NA	NA
VEG72417.1\|5772344_5772998_-	putative kinase inhibitor protein	NA	NA	NA	NA
VEG72419.1\|5773227_5774457_-\|tRNA	Tyrosine--tRNA ligase	NA	NA	NA	NA
VEG72421.1\|5774711_5776121_+	Glycyl-glycine endopeptidase ALE-1 precursor	A8ATH6	Listeria_phage	4.6e-17	43.8
VEG72423.1\|5776197_5777331_+	Anhydro-N-acetylmuramic acid kinase	NA	NA	NA	NA
VEG72425.1\|5777395_5777767_-	Iron-sulfur cluster insertion protein erpA	A0A2H4N7M3	Lake_Baikal_phage	6.2e-30	57.4
VEG72426.1\|5777853_5778600_-	Uncharacterised protein	NA	NA	NA	NA
VEG72428.1\|5778643_5779708_-	N-acetyl-gamma-glutamyl-phosphate reductase	NA	NA	NA	NA
VEG72431.1\|5779918_5780311_-	30S ribosomal protein S9	NA	NA	NA	NA
VEG72433.1\|5780320_5780749_-	50S ribosomal protein L13	NA	NA	NA	NA
VEG72435.1\|5781056_5781767_-	LIV-I protein F	A0A2H4PQG7	Staphylococcus_phage	5.9e-13	25.2
VEG72437.1\|5781822_5782611_-	Lipopolysaccharide export system ATP-binding protein LptB	A0A2R8FG22	Brazilian_cedratvirus	1.8e-15	26.0
VEG72439.1\|5782603_5783479_-	leucine/isoleucine/valine transporter permease subunit	NA	NA	NA	NA
VEG72441.1\|5783482_5784412_-	LIV-I protein H	NA	NA	NA	NA
VEG72443.1\|5784533_5785688_-	Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor	NA	NA	NA	NA
VEG72445.1\|5785944_5787042_-	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component	NA	NA	NA	NA
VEG72448.1\|5787212_5788577_-	peptidase PmbA	NA	NA	NA	NA
VEG72452.1\|5788635_5789187_+	x96 protein	NA	NA	NA	NA
VEG72457.1\|5789204_5789882_+	Carboxylesterase 2	NA	NA	NA	NA
VEG72459.1\|5790223_5791228_+	ABC-type taurine transport system, periplasmic component	NA	NA	NA	NA
VEG72465.1\|5791224_5792043_+	Aliphatic sulfonates import ATP-binding protein SsuB	G3M9Y6	Bacillus_virus	2.7e-33	39.3
VEG72468.1\|5792045_5792882_+	Putative aliphatic sulfonates transport permease protein ssuC	NA	NA	NA	NA
VEG72470.1\|5792891_5793584_+	Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB	NA	NA	NA	NA
VEG72472.1\|5793608_5796050_-	N-acyltransferase YncA	NA	NA	NA	NA
VEG72474.1\|5796170_5797577_+\|tRNA	Glutamate--tRNA ligase	NA	NA	NA	NA
5802013:5802029	attR	NA	NA	NA	NA

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. LR134361

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CRISPR-Cas detection and classification

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Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

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Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection