CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
LR134390	Fusobacterium varium strain NCTC10560 genome assembly, chromosome: 1	3 crisprs	WYL,DinG,DEDDh,cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6,csa3,csm6	2	11	4	0

Results visualization

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CRISPR-Cas detection and classification

Crispr_ID: LR134390_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134390_3

1233343-1234593

Orphan

Consensus_repeat	Method
ATTTAAAAACTTCCAAGTTACTATTCAAG	CRT
ATTTAAAAACTTCCAAGTTACTATTCAAG	CRISPRCasFinder
ATTTAAAAACTTCCAAGTTACTATTCAAG	PILER-CR

19 spacers

The CRISPR arrays of LR134390_3

>merge|LR134390|3|1233343-1234593|CRT,CRISPRCasFinder,PILER-CR
GGGAGAAAACTTATGAGTTGAGATTCAATCTTACTGCTGAGAAAGAATTTGATGGAAAAGTATATTTAAAAACTTATCAGTTGATATTCAATTTGGAGCAATTGATATATCGAATCAACTAGAGGTATTTAAAAACTTCCAAGTTACTATTCAAGACTACATCTCTTCCATTATCTGCATTTTCAATTATTATTTAAAAACTTCCAAGTTACTATTCAAGAAAACCCTACACATTTTTTTATGTGTAGGATTTGCATTTAAAAACTTCCAAGTTACTATTCAAGTTATATAATATTTCTATTCAAATACTACTTTGTATATTTAAAAACTTCCAAGTTACTATTCAAGAGGAATACCTCTTATAGTTTTAAGCTGGTTTAGATGATTTAAAAACTTCCAAGTTACTATTCAAGACTCCGAAAAAAGCTGAAATATAAGGAGTTATTATAATTTAAAAACTTCCAAGTTACTATTCAAGAGAAAATGCTGAAATGTTAAAGGTTCTTAAAAGTGTATTTAAAAACTTCCAAGTTACTATTCAAGACTAAATATAAAGGACCTAAAGGATTATATATATAAATTTAAAAACTTCCAAGTTACTATTCAAGTATTTATCGTTTTACAGTATGACAGGAGCAGTAGAATTTAAAAACTTCCAAGTTACTATTCAAGATTGGTCAAGAAAAGAGATACTGAATTAACTTATAATTTAAAAACTTCCAAGTTACTATTCAAGTTTCTTAGTCTTTCTAATACTTTTAAGTCCTGTGTCATTTAAAAACTTCCAAGTTACTATTCAAGAGCAGTGTTAGATTCAATTTTAGAATTTCTTTTAATATTTAAAAACTTCCAAGTTACTATTCAAGTATGAATGTATTTATGAATATAGTTATACTACTGATTTAAAAACTTCCAAGTTACTATTCAAGCAGGCAATATATTAAGAGATAAGTATGAGAAACTATTTAAAAACTTCCAAGTTACTATTCAAGAGTTAAGTATAGCAACTGATTTAAGTGAGCTATATATTTAAAAACTTCCAAGTTACTATTCAAGTCATTTATTATCTCCTTTAAAAATTATTTTTACACCATTTAAAAACTTCCAAGTTACTATTCAAGACATTAACGAAATGATTTTTAATTCTGTGGACTATAATTTAAAAACTTCCAAGTTACTATTCAAGATAGACTTCCTTACACCTCTACAAGTATGTGGCCCAATTTAAAAACTTCCAAGTTACTATTCAAG

>LR134390|3|1|1233343-1234593|CRT
GGGAGAAAACTTATGAGTTGAGATTCAAT	CTTACTGCTGAGAAAGAATTTGATGGAAAAGTAT
ATTTAAAAACTTATCAGTTGATATTCAAT	TTGGAGCAATTGATATATCGAATCAACTAGAGGT
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACTACATCTCTTCCATTATCTGCATTTTCAATTATT
ATTTAAAAACTTCCAAGTTACTATTCAAG	AAAACCCTACACATTTTTTTATGTGTAGGATTTGC
ATTTAAAAACTTCCAAGTTACTATTCAAG	TTATATAATATTTCTATTCAAATACTACTTTGTAT
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGGAATACCTCTTATAGTTTTAAGCTGGTTTAGATG
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACTCCGAAAAAAGCTGAAATATAAGGAGTTATTATA
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGAAAATGCTGAAATGTTAAAGGTTCTTAAAAGTGT
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACTAAATATAAAGGACCTAAAGGATTATATATATAA
ATTTAAAAACTTCCAAGTTACTATTCAAG	TATTTATCGTTTTACAGTATGACAGGAGCAGTAGA
ATTTAAAAACTTCCAAGTTACTATTCAAG	ATTGGTCAAGAAAAGAGATACTGAATTAACTTATA
ATTTAAAAACTTCCAAGTTACTATTCAAG	TTTCTTAGTCTTTCTAATACTTTTAAGTCCTGTGTC
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGCAGTGTTAGATTCAATTTTAGAATTTCTTTTAAT
ATTTAAAAACTTCCAAGTTACTATTCAAG	TATGAATGTATTTATGAATATAGTTATACTACTG
ATTTAAAAACTTCCAAGTTACTATTCAAG	CAGGCAATATATTAAGAGATAAGTATGAGAAACT
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGTTAAGTATAGCAACTGATTTAAGTGAGCTATAT
ATTTAAAAACTTCCAAGTTACTATTCAAG	TCATTTATTATCTCCTTTAAAAATTATTTTTACACC
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACATTAACGAAATGATTTTTAATTCTGTGGACTATA
ATTTAAAAACTTCCAAGTTACTATTCAAG	ATAGACTTCCTTACACCTCTACAAGTATGTGGCCCA
ATTTAAAAACTTCCAAGTTACTATTCAAG

>LR134390|3|3|1233406-1234593|CRISPRCasFinder
ATTTAAAAACTTATCAGTTGATATTCAAT	TTGGAGCAATTGATATATCGAATCAACTAGAGGT
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACTACATCTCTTCCATTATCTGCATTTTCAATTATT
ATTTAAAAACTTCCAAGTTACTATTCAAG	AAAACCCTACACATTTTTTTATGTGTAGGATTTGC
ATTTAAAAACTTCCAAGTTACTATTCAAG	TTATATAATATTTCTATTCAAATACTACTTTGTAT
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGGAATACCTCTTATAGTTTTAAGCTGGTTTAGATG
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACTCCGAAAAAAGCTGAAATATAAGGAGTTATTATA
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGAAAATGCTGAAATGTTAAAGGTTCTTAAAAGTGT
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACTAAATATAAAGGACCTAAAGGATTATATATATAA
ATTTAAAAACTTCCAAGTTACTATTCAAG	TATTTATCGTTTTACAGTATGACAGGAGCAGTAGA
ATTTAAAAACTTCCAAGTTACTATTCAAG	ATTGGTCAAGAAAAGAGATACTGAATTAACTTATA
ATTTAAAAACTTCCAAGTTACTATTCAAG	TTTCTTAGTCTTTCTAATACTTTTAAGTCCTGTGTC
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGCAGTGTTAGATTCAATTTTAGAATTTCTTTTAAT
ATTTAAAAACTTCCAAGTTACTATTCAAG	TATGAATGTATTTATGAATATAGTTATACTACTG
ATTTAAAAACTTCCAAGTTACTATTCAAG	CAGGCAATATATTAAGAGATAAGTATGAGAAACT
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGTTAAGTATAGCAACTGATTTAAGTGAGCTATAT
ATTTAAAAACTTCCAAGTTACTATTCAAG	TCATTTATTATCTCCTTTAAAAATTATTTTTACACC
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACATTAACGAAATGATTTTTAATTCTGTGGACTATA
ATTTAAAAACTTCCAAGTTACTATTCAAG	ATAGACTTCCTTACACCTCTACAAGTATGTGGCCCA
ATTTAAAAACTTCCAAGTTACTATTCAAG

>LR134390|3|1|1233469-1234593|PILER-CR
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACTACATCTCTTCCATTATCTGCATTTTCAATTATT
ATTTAAAAACTTCCAAGTTACTATTCAAG	AAAACCCTACACATTTTTTTATGTGTAGGATTTGC
ATTTAAAAACTTCCAAGTTACTATTCAAG	TTATATAATATTTCTATTCAAATACTACTTTGTAT
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGGAATACCTCTTATAGTTTTAAGCTGGTTTAGATG
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACTCCGAAAAAAGCTGAAATATAAGGAGTTATTATA
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGAAAATGCTGAAATGTTAAAGGTTCTTAAAAGTGT
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACTAAATATAAAGGACCTAAAGGATTATATATATAA
ATTTAAAAACTTCCAAGTTACTATTCAAG	TATTTATCGTTTTACAGTATGACAGGAGCAGTAGA
ATTTAAAAACTTCCAAGTTACTATTCAAG	ATTGGTCAAGAAAAGAGATACTGAATTAACTTATA
ATTTAAAAACTTCCAAGTTACTATTCAAG	TTTCTTAGTCTTTCTAATACTTTTAAGTCCTGTGTC
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGCAGTGTTAGATTCAATTTTAGAATTTCTTTTAAT
ATTTAAAAACTTCCAAGTTACTATTCAAG	TATGAATGTATTTATGAATATAGTTATACTACTG
ATTTAAAAACTTCCAAGTTACTATTCAAG	CAGGCAATATATTAAGAGATAAGTATGAGAAACT
ATTTAAAAACTTCCAAGTTACTATTCAAG	AGTTAAGTATAGCAACTGATTTAAGTGAGCTATAT
ATTTAAAAACTTCCAAGTTACTATTCAAG	TCATTTATTATCTCCTTTAAAAATTATTTTTACACC
ATTTAAAAACTTCCAAGTTACTATTCAAG	ACATTAACGAAATGATTTTTAATTCTGTGGACTATA
ATTTAAAAACTTCCAAGTTACTATTCAAG	ATAGACTTCCTTACACCTCTACAAGTATGTGGCCCA
ATTTAAAAACTTCCAAGTTACTATTCAAG

Protein	Signature genes	Signature genes Name	Protein_function
LR134390.1\|VEH38922.1\|1229512_1230307_-\|Nicotinate-dehydrogenase-FAD-subunit	unknown	unknown	gnl\|CDD\|224238
LR134390.1\|VEH38934.1\|1242132_1242456_-\|Uncharacterised-protein	unknown	unknown	gnl\|CDD\|367818
LR134390.1\|VEH38930.1\|1239801_1240065_-\|Uncharacterised-protein	unknown	unknown	unknown
LR134390.1\|VEH38921.1\|1229042_1229513_-\|4-hydroxybenzoyl-CoA-reductase-subunit-gamma	unknown	unknown	gnl\|CDD\|224991
LR134390.1\|VEH38919.1\|1225399_1226128_+\|Cobalt-import-ATP-binding-protein-CbiO	unknown	unknown	gnl\|CDD\|213192
LR134390.1\|VEH38931.1\|1240241_1240598_-\|Uncharacterised-protein	unknown	unknown	unknown
LR134390.1\|VEH38918.1\|1224602_1225382_+\|cobalt-transport-protein-CbiQ	unknown	unknown	gnl\|CDD\|274139
LR134390.1\|VEH38920.1\|1226815_1229059_-\|4-hydroxybenzoyl-CoA-reductase-subunit-alpha	unknown	unknown	gnl\|CDD\|236637
LR134390.1\|VEH38916.1\|1222706_1223615_+\|tRNA-specific-2-thiouridylase-MnmA	unknown	unknown	gnl\|CDD\|238948
LR134390.1\|VEH38927.1\|1235913_1236936_+\|2-aminoethylphosphonate-ABC-transporter-substrate-binding-protein	unknown	unknown	gnl\|CDD\|270262
LR134390.1\|VEH38928.1\|1236951_1238634_+\|Molybdenum-transport-system-permease-protein-modB	unknown	unknown	gnl\|CDD\|224099
LR134390.1\|VEH38929.1\|1238647_1239712_+\|Spermidine/putrescine-import-ATP-binding-protein-PotA	unknown	unknown	gnl\|CDD\|226361
LR134390.1\|VEH38925.1\|1232906_1233038_+\|Uncharacterised-protein	unknown	unknown	unknown
LR134390.1\|VEH38917.1\|1223617_1224610_+\|Energy-coupling-factor-transporter-probable-substrate-capture-protein-NikMN	unknown	unknown	gnl\|CDD\|376649
LR134390.1\|VEH38924.1\|1232323_1232530_-\|Uncharacterised-protein	unknown	unknown	unknown
LR134390.1\|VEH38935.1\|1242619_1243381_+\|Exodeoxyribonuclease	unknown	unknown	gnl\|CDD\|197321
LR134390.1\|VEH38923.1\|1230450_1231758_-\|Xanthine-permease-XanQ	unknown	unknown	gnl\|CDD\|274468
LR134390.1\|VEH38926.1\|1235031_1235757_+\|Putative-glutamine-amidotransferase-Rv2859c	unknown	unknown	gnl\|CDD\|224982
LR134390.1\|VEH38932.1\|1240645_1241254_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|176459
LR134390.1\|VEH38933.1\|1241423_1241696_-\|DNA-polymerase-IV	unknown	unknown	gnl\|CDD\|176459

Protein	Function_ID	Function_description	E-value
LR134390.1\|VEH38922.1\|1229512_1230307_-\|Nicotinate-dehydrogenase-FAD-subunit	gnl\|CDD\|224238	COG1319, CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion].	2.7718e-30
LR134390.1\|VEH38934.1\|1242132_1242456_-\|Uncharacterised-protein	gnl\|CDD\|367818	pfam04108, APG17, Autophagy protein Apg17. Apg17 is required for activating Apg1 protein kinases.	0.00462631
LR134390.1\|VEH38921.1\|1229042_1229513_-\|4-hydroxybenzoyl-CoA-reductase-subunit-gamma	gnl\|CDD\|224991	COG2080, CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion].	1.87544e-46
LR134390.1\|VEH38919.1\|1225399_1226128_+\|Cobalt-import-ATP-binding-protein-CbiO	gnl\|CDD\|213192	cd03225, ABC_cobalt_CbiO_domain1, First domain of the ATP-binding cassette component of cobalt transport system. Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.	8.32361e-87
LR134390.1\|VEH38935.1\|1242619_1243381_+\|Exodeoxyribonuclease	gnl\|CDD\|197321	cd09087, Ape1-like_AP-endo, Human Ape1-like subfamily of the ExoIII family apurinic/apyrimidinic (AP) endonucleases. This subfamily includes human Ape1 (also known as Apex, Hap1, or Ref-1) and related proteins. These are Escherichia coli exonuclease III (ExoIII)-like AP endonucleases and they belong to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. AP endonucleases participate in the DNA base excision repair (BER) pathway. AP sites are one of the most common lesions in cellular DNA. During BER, the damaged DNA is first recognized by DNA glycosylase. AP endonucleases then catalyze the hydrolytic cleavage of the phosphodiester bond 5' to the AP site, and this is followed by the coordinated actions of DNA polymerase, deoxyribose phosphatase, and DNA ligase. If left unrepaired, AP sites block DNA replication, and have both mutagenic and cytotoxic effects. AP endonucleases can carry out a variety of excision and incision reactions on DNA, including 3'-5' exonuclease, 3'-deoxyribose phosphodiesterase, 3'-phosphatase, and occasionally, nonspecific DNase activities. Different AP endonuclease enzymes catalyze the different reactions with different efficiences. Many organisms have two AP endonucleases, usually one is the dominant AP endonuclease, the other has weak AP endonuclease activity; for example, Ape1 and Ape2 in humans. Ape1 is found in this subfamily, it exhibits strong AP-endonuclease activity but shows weak 3'-5' exonuclease and 3'-phosphodiesterase activities. Class II AP endonucleases have been classified into two families, designated ExoIII and EndoIV, based on their homology to the Escherichia coli enzymes exonuclease III (ExoIII) and endonuclease IV (EndoIV). This subfamily belongs to the ExoIII family; the EndoIV family belongs to a different superfamily.	2.20894e-167
LR134390.1\|VEH38918.1\|1224602_1225382_+\|cobalt-transport-protein-CbiQ	gnl\|CDD\|274139	TIGR02454, Uncharacterized_protein_MJ1089, cobalt ECF transporter T component CbiQ. This model represents the CbiQ component of the cobalt-specific ECF-type. CbiQ is now recognized as the T component of energy-coupling factor (ECF)-type transporters. The S component confers specificity (CbiM-N for cobalt systems), which CbiO is the ABC-family ATPase. In general, proteins found by this model reside next to the other putative subunits of the complex, identified as CbiN, CbiO, or CbiM. Note that the designation of cobalt transporter has been spread excessively among ECF system transporters with many other specificities. [Transport and binding proteins, Cations and iron carrying compounds].	1.02868e-28
LR134390.1\|VEH38920.1\|1226815_1229059_-\|4-hydroxybenzoyl-CoA-reductase-subunit-alpha	gnl\|CDD\|236637	PRK09970, PRK09970, xanthine dehydrogenase subunit XdhA; Provisional.	0
LR134390.1\|VEH38916.1\|1222706_1223615_+\|tRNA-specific-2-thiouridylase-MnmA	gnl\|CDD\|238948	cd01990, Alpha_ANH_like_I, This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily of proteins probably binds ATP. This domain is about 200 amino acids long with a strongly conserved motif SGGKD at the N terminus.	3.78798e-88
LR134390.1\|VEH38927.1\|1235913_1236936_+\|2-aminoethylphosphonate-ABC-transporter-substrate-binding-protein	gnl\|CDD\|270262	cd13544, PBP2_Fbp_like_1, Substrate binding domain of a putative ferric iron transporter, a member of the type 2 periplasmic binding fold superfamily. The substrate domain of this group shows a high homology to the periplasmic component of ferric iron transporter (Fbp), but its biochemical characterization has not been performed. The periplasmic iron binding protein plays an essential role in the iron uptake pathway of Gram-negative pathogenic bacteria from the Pasteurellaceae and Neisseriaceae families and is critical for survival of these pathogens within the host. After binding iron with high affinity, Fbp interacts with a cognate membrane transport complex comprised of two integral membrane domains and two cytoplasmically located ATPase. This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. The ferric iron-binding proteins belong to the PBP2 superfamily of periplasmic binding proteins that differ in size and ligand specificity, but have similar tertiary structures consisting of two globular subdomains connected by a flexible hinge. They have been shown to bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.	7.26961e-152
LR134390.1\|VEH38929.1\|1238647_1239712_+\|Spermidine/putrescine-import-ATP-binding-protein-PotA	gnl\|CDD\|226361	COG3842, PotA, ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism].	6.79984e-153
LR134390.1\|VEH38917.1\|1223617_1224610_+\|Energy-coupling-factor-transporter-probable-substrate-capture-protein-NikMN	gnl\|CDD\|376649	pfam01891, CbiM, Cobalt uptake substrate-specific transmembrane region. This family of proteins forms part of the cobalt-transport complex in prokaryotes, CbiMNQO. CbiMNQO and NikMNQO are the most widespread groups of microbial transporters for cobalt and nickel ions and are unusual uptake systems as they consist of eg two transmembrane components (CbiM and CbiQ), a small membrane-bound component (CbiN) and an ATP-binding protein (CbiO) but no extracytoplasmic solute-binding protein. Similar components constitute the nickel transporters with some variability in the small membrane-bound component, either NikN or NikL, which are not similar to CbiN at the sequence level. CbiM is the substrate-specific component of the complex and is a seven-transmembrane protein. The CbiMNQO and NikMNQO systems form part of the coenzyme B12 biosynthesis pathway. The NikM protein is pfam10670.	6.37537e-51
LR134390.1\|VEH38926.1\|1235031_1235757_+\|Putative-glutamine-amidotransferase-Rv2859c	gnl\|CDD\|224982	COG2071, COG2071, Predicted glutamine amidotransferases [General function prediction only].	1.17904e-81
LR134390.1\|VEH38923.1\|1230450_1231758_-\|Xanthine-permease-XanQ	gnl\|CDD\|274468	TIGR03173, pbuX, xanthine permease. All the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.	4.12605e-132
LR134390.1\|VEH38928.1\|1236951_1238634_+\|Molybdenum-transport-system-permease-protein-modB	gnl\|CDD\|224099	COG1178, ThiP, ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism].	3.59341e-115
LR134390.1\|VEH38932.1\|1240645_1241254_-\|DNA-polymerase-IV	gnl\|CDD\|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	8.835e-50
LR134390.1\|VEH38933.1\|1241423_1241696_-\|DNA-polymerase-IV	gnl\|CDD\|176459	cd03586, PolY_Pol_IV_kappa, DNA Polymerase IV/Kappa. Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.	3.24523e-40

>LR134390.1|VEH38925.1|1232906_1233038_+|Uncharacterised-protein
MAGMLHDIYTYKFEYSKDHGQKGAIMARKILENYRWQLLQKLI
>LR134390.1|VEH38924.1|1232323_1232530_-|Uncharacterised-protein
MTLLKKFKDKKVHIILNTADKISFDGKIIDEFENFIEITTDYSQYANHQQHILNKNFILQIYEYKEEY
>LR134390.1|VEH38923.1|1230450_1231758_-|Xanthine-permease-XanQ
MRNTSPYDLDGIPVLREAIPLGLQHILAMFVSNITPLIIVAGAMKMPSETKTFLIQCTMLVAGVNTLIQAYRIGPIGARLPIVVGTSFAFVPVALSIGSKYGYEGILGAALVGAIFEIFIGAIIKKIRRYFPPVVTGVIVLSIGLSLLPVGVSNFAGGVGSADFGSFPNLFIGMVVLITVIFFKQFTKGITSTGSIFVGTVVGFIVAFFMGKVDLTPVRNAAIISFPTPFTYGITFHADACLAMIMMFIVSAVETVGDMSGVTMGGANREVTDKELSGGILADGFGSALASVFSVLPTTSFSQNTGIVAMTGIMSRFVVGTGAAFLVAGAFFPKIGAILSIVPASVLGGSLVMIFAMISISGINLITKEPLVGRNAVILSVSLGLGYGLGSVPAALKYFPESIQLIFGGSGIVVSGSIAVILNIVLPLDEKLKKH
>LR134390.1|VEH38922.1|1229512_1230307_-|Nicotinate-dehydrogenase-FAD-subunit
MFSFSKYFPAQSLQEAYDELLKNKKNIILGGTSYLRMENTSYNTAIDLSSLSLNYIKEEEKYIHIGAMVSFREIETNPIILNLFDGVLSKSVNNIIGVQFRNNVTVGATVFSKYGFSDLIPALLALDTTVILFNGGEISLEEYLSIEGKTRDILVEIKIRKTNGKGAFKSIRKSKTDYAITNTAVTNENGTFKIAIGVRPGKAKLAHKAMEILNNSDNITDEVIDRACSFIDEEITFGSNMRGSSEYRAAISKVITKRALKEVL
>LR134390.1|VEH38921.1|1229042_1229513_-|4-hydroxybenzoyl-CoA-reductase-subunit-gamma
MLLTLTVNGLKRELLISEDEYLLDTLRKAGYLSVKRGCDTGSCGLCTVLVDDKPILSCSTLSARMNNKRITTIEGCQEEAMKFANFMADEGAEQCGYCAPGFTLTVLAMMKEYKNPTDEEILHYLNGNLCRCSGYVSQLRAIKNFMEAEKSNENSK
>LR134390.1|VEH38920.1|1226815_1229059_-|4-hydroxybenzoyl-CoA-reductase-subunit-alpha
MKIVNKSIKKIDSIGIITGRPLYTDDLVINNNSLIVKLLRSPHPFAKILDIDTSIAKKVPGVEAIYTHHDVPKTMFTLAGQSYPEPSPYDRKILSEYVRYVGDPVAIVAAVDEKTAEKAMKLIKVKYEILEAVIDYEKALDSDILVHPEDIHINFPIGFDNKRNLASSYLETKGDVDRGFEESDVIIEKTYYTQPQIHAMMETYRTACYLDAHGRLVVVSSTQIPFHVRRHLARALEIPSSRIRVIKPKIGGGFGGKQTSVCEIYPAFVTMKTGKPSKIIYSRKETQAYSNTRHAMRLKVKIGSDNEGNIKAIDINVLSNTGAYGEHAPTVTSLVVYKTFPLYAKVPMRCKADIVYSNTMVGAAFRGYGATQGTFAVESAVNELAHKLGIDPTEIRMKNLVNQSEKVSGDIKKCISIGKEAFDWKNRTVKDMGNGKVRASGMAVTMQGSGIANVDTASATLKLHDSGDYTLYLGVTDMGQGCDTVLAQMASEILEVPVEKIIVNTADTDTSPYDPGAYASSGTYVTGNAVILAAEKMKKEIIDMASKLMKIPAEEVEYLGESVQDKNGNTLSLRDIGERAVSFEGKNQIITTATWGGETSPPPFIASFAEVEVDTLTGHTEVIDFLSVVDCGVPINPALAQVQVEGGIAQGIGLALYEDIQFDKNGKVKHDTLMQYKIPSRKDLGNIKVLFSYSNEPTGPFGAKSIGEVVINTASPAIADAIYNATKARVRSLPITSEKLFWEIHAK
>LR134390.1|VEH38919.1|1225399_1226128_+|Cobalt-import-ATP-binding-protein-CbiO
MQRIKIEHLNFSYRGFKEVLTDINLEISVGETIGIIGENGAGKSTLLKLIIGLLSDYSGKIEIDKVEVKKSTLSDIRKKIGYVFQDSDSQLFMSNVYDDIAFAPQNYGYSEEETERCVEKAMKTVKIEDLKNRMIYQLSGGQKKLVSLAAVLSIEPEIILLDEPSAALDPKNRRNLINILNSIKGIKVIASHDLDMILDTCDKTILISKGKIIKEGNTENILSDKNLLEENGLELPLSFRWK
>LR134390.1|VEH38918.1|1224602_1225382_+|cobalt-transport-protein-CbiQ
MSKLNEAIHTIHYLDRMSLENKWINNIHPLVKLVVTFVYISVLISFNKYNLTGLAGMSIYIAVVFILGRISLRQSIKQLRGIIIILCIIGIANPFLDKKVLLDIGTVKITGGVISMATLIAKGVLSVLASYFLIATTSIENICYALRIIHIPKIFVTVVLLIYRYIILFLKEVERMTTAYELRAPNQKGIHIKVWGSMVGMLLLRSIDRAQTVYESMLLRGFDGEFKMKSSGESLLKSYIYCIFWVGAIIFFRLHQSDY
>LR134390.1|VEH38917.1|1223617_1224610_+|Energy-coupling-factor-transporter-probable-substrate-capture-protein-NikMN
MHMADALITPTVAGAMYICSAAAAKYSMKKLSLENDPKKIPLMGIMGAFVFAAQMINFTIPGTGSSGHLCGGMLLSAVLGPYAGFLTMIGVLFIQCLLFADGGILAFGANVWNMAFYGCFIGAMIIWRYTMAKGITKKKIILASIIGSVVTLQLGAFSVTLETLASNITELPFAVFVSAMQPIHLAIGLVEGLITASVLCFIFEARPELLWESCEKEGKVSYKNTVIILAAVASVIGGLLSLMASSHPDGLEWSIEKIAGSPELQASGTAYDIAEKIQGATALLPDYSFKGSESMFGTSFSGIIGGIAVVVLCILSCYLFNFFRGKSKNE
>LR134390.1|VEH38916.1|1222706_1223615_+|tRNA-specific-2-thiouridylase-MnmA
MITKEAGRKEINAKETGIKEINTKETSTYKEKNIFLQNLMEKYTMENVAVAFSGGVDSSLLLKAACLSAVKNGKKVYAVTMHTTLHPMNEIESSKKTAEEIGAEHLIIKVDELREAGIENNPVERCYLCKKYLFQKILDKAESLGIKTVLDGTNEDDLHLFRPGLKALRELGIKSPLAESGFTKSDVRKLAEEYGLSVSKKPSTPCLATRFPYGSRLTYEEMQKVEKGENFLKNLGLYNVRLRIHGDIARIETDKEDIEKIVKYREKTISYLKKLGYRYITIDLEGFRSGSMDYFLENKREE
>LR134390.1|VEH38926.1|1235031_1235757_+|Putative-glutamine-amidotransferase-Rv2859c
MKPIIGITTFREMREKGEYNSINYGYAEAILAAGGLPVFIPIVPEGIAKEYLEDYRLDGIIFSGGADVAPRFYGEDPGLQIPGIDTKRDIMEFELLEEAVKRKIPVLGICRGHQLINVAFDGTLYQDIDTQVQSAMGHHPSHINRDELFHSVNIKKESVLHDIFGDEKIYVNSFHHQAVKKLGKGLKATAFSCEGIVEAFETVDMNERFVLGIQWHPENLVNRYNEFLGIFKLLVDRAKER
>LR134390.1|VEH38927.1|1235913_1236936_+|2-aminoethylphosphonate-ABC-transporter-substrate-binding-protein
MKKLSAIVITFLLSLTTTFAAGEKETEHLLIYAGLMEDHAIAAVKEFEKETGIKTEFVRMSSGETLARIRAEKDNMTASVWFGGPIDAFVAANEENLIEPYISPVAKDIPDKFKDPNGIWTGIYVGYLGFVGNKEVLKEIGAEMPKSWADLLKPEYKGEIVTAHPGSSGTAFTMLATIVQLKGEKDGMAYMQKLNEQVRQYTKSGTAPGRMVGLGETAVGITFLHDAIKYRKEGYEDIIISAPEEGTGFEIGGVAILKNGPDQVSAKKFVDWALSKKAQELGQTVGSFQFLTNQTANAPEDVKEIAGTKLIDYNFEWAGKNRKDLLDKFSTATKTTAPTK
>LR134390.1|VEH38928.1|1236951_1238634_+|Molybdenum-transport-system-permease-protein-modB
MSNLQLKINTELKNMKKVFNDPILFSTIVFILVILIMFILFPMYNILKESFTYKGEFSLIHYKNIKEMQENFIIILNTLKLGVVTSVISTAIGFFFAYGMTYVKIPFRKFFNSIAILPIVSPPFVIALSAILLLGRRGFITRNLLGIRNAEIYGFHGLVLVQVLTFFPVAYLMLVGLLQKIDPSVEEASRDLGASRWDVFRTITFPLMIPGLANAILVIFIQAIADFGNPMVIGGNFTTVAVQIYLQGIGNYDMGSATALAVVLILMSISIFVTQKYYISKKSYVTVTGKVSREREKISEKNITMPIFIIMAFLTFCVFLMYIMIPIGSFVKLWGVKYDFSLEHYKYVFALGMKPIWDTTFLSIISTPITGILAMIIAFLIVRRKFLGKGFIEFITMMAIAIPGTIVGLGYIITYNTKPFVLTGTATILIIAFIMRNMPIGIRSGIAALQQIDPSIEEAATVLGANSKKVFTSVTLPMIKPAFFSGLVYAFVRSMTLVSTIIFLVSAKYNLLTVAIMNQIDVGKIGVASAYCTILIIIVFFVIGIMTYILKKMGIDSISE
>LR134390.1|VEH38929.1|1238647_1239712_+|Spermidine/putrescine-import-ATP-binding-protein-PotA
MGAKRVKFENINKIFLTGDNRKVHAVADLNLDIKAGEFICLLGPSGCGKTTILRMLAGFEVPTEGHIYIGDENVERITPDKRDTAMVFQNYALFPHMNVYDNIAYGLKLQKLPKSEVDERVHRILKMMNMEDFAERVPSQMSGGQQQRVSLARALVMEPGVLLFDEPLSNLDAKLRIHMRDEIRKIQQQVGITSIYVTHDQAEAMGLADKIIIMKDGRIQQAGSPIEIYQNPVNEFVANFIGRANIFTGELVYKTDNKCTIDICGVRYEVPQKVTHNIGDEIKIVARPESIIISKNDFKGKVIKSMFMGAYHEYEVMFEGFKVEISVSNPKGKKTYALDSELDFSLDVESIHIL
>LR134390.1|VEH38930.1|1239801_1240065_-|Uncharacterised-protein
MFRSLIVFALTFLLVIFGLEYIMPPFGTIMYLNPIEIVGSIAYSIAYVTGMHVKLSIFLAVASISIIPLFMVIIVNRICKKKKKRRF
>LR134390.1|VEH38931.1|1240241_1240598_-|Uncharacterised-protein
MNINFKLGSTTGKAGILSIECQKLNIPYVVVVFRNVLNYPNSVQIFKLKSNPKNEASEIKAVEEICKIADKYAITLVMKLAIRNRKHLIETFSKFGFKTKKSWLGNCPELIREYSSLD
>LR134390.1|VEH38932.1|1240645_1241254_-|DNA-polymerase-IV
MASNINKPHGQYIFLSPLDFSKYISDKNIGIIPGVGRKLSSLLAKDSIFKVKDIYPYSLSALCTSYGKSRGELLYSFSRGIDYREVEYKKPIHSIGNENTFKYPLNTELEIKREFDDLFEHSYKRLLKDDFISKTIILKIRFSSNETITRSKTLEIPTDSYEKLKKVSEDLLENIDLIDSIRLLGISFGNLTKKSVRQLAFF
>LR134390.1|VEH38933.1|1241423_1241696_-|DNA-polymerase-IV
MKKDRTILHYDMDAYYASIEIRDNPKLLNKPLVVGGSIVTTASYEARKFGIHSAMKVSDAKKLCPSLLVIPVNKEKYSEISKKYKDLSFV
>LR134390.1|VEH38934.1|1242132_1242456_-|Uncharacterised-protein
MANLKNIINNLKLKDEVDEAVKESLEILSEFSNLKLNNLEKEIERNLISGAFENSNFKVPILNIITKHSGEIARILESEDIFIDNILIILKEIFKDNNAITEVIIKK
>LR134390.1|VEH38935.1|1242619_1243381_+|Exodeoxyribonuclease
MKLISWNVNGLRAAVQKGFLDYFKNENADIFCIQETKLQEGQIELDLEGYHQYWNYAEKKGYSGTAIFTKKKPIEVSYGLGIEEHDKEGRVITLEYEDFYMITVYTPNSQEELARLDYRMSWEDEFRNYVMKLDKLKPVIICGDLNVAHKEIDLKNPKSNRKNAGFSDEERAKFTELLENGFIDSFRHFYPEVTGAYSWWSYRFNARKNNAGWRIDYFVVSERLKDIMEGAEIHNEILGSDHCPVVLKLKKEF

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Crispr_ID: LR134390_4

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134390_4

1475641-1477224

TypeI-B

Consensus_repeat	Method
ATTTAAAAACTTCTAAGTTACTATTCAAC	PILER-CR
ATTTAAAAACTTCTAAGTTACTATTCAAC	CRISPRCasFinder
ATTTAAAAACTTCTAAGTTACTATTCAAC	CRT

24 spacers

cas2,cas1,cas4,cas3,cas5,cas7b,cas8b1,cas6

The CRISPR arrays of LR134390_4

>merge|LR134390|4|1475641-1477224|PILER-CR,CRISPRCasFinder,CRT
ATTTAAAAACTTCTGAGTTACTATTCAACTTTGTAACAAATAGCAGTAGCAGTAGTTATATATGATTTAAAAACTTCTAAGTTACTATTCAACTTTTTCCTAGCAAGAAATATAATTTTATAAGTTGGTATTTAAAAACTTCTAAGTTACTATTCAACAATTTGAAAAATGAAGTTAGAAAAAATAATACTTTTATTTAAAAACTTCTAAGTTACTATTCAACCACCTGCACATGAACCATTTTGTTTTATTAATTCCATTTAAAAACTTCTAAGTTACTATTCAACGATTACAGGATATAAAATATTAGACAAAATAAGAATATTTAAAAACTTCTAAGTTACTATTCAACGATTACAGGATATAAAATATTAGACAAAATAAGAATATTTAAAAACTTCTAAGTTACTATTCAACTAAAATAGATAGTGCAGTAATGGATTTTATTAATGGATTTAAAAACTTCTAAGTTACTATTCAACAAATTAATTGCATTTTTAAAGTTAAGGGGGTAAAAATTTAAAAACTTCTAAGTTACTATTCAACTCAAACTTTCAGAGCTGGTACTTTTATATCTGAATATTTAAAAACTTCTAAGTTACTATTCAACTTGACTACAGAAGAAATGAACCTAAAATTTCAAAAATTTAAAAACTTCTAAGTTACTATTCAACAGCATACAAAGAAATAATAATGGCTAGAAAGCTGTAATTTAAAAACTTCTAAGTTACTATTCAACTCTGTTCTTTTTTTTCTTAGCTTTATTTCTCCTTTTATTTAAAAACTTCTAAGTTACTATTCAACATCCATGCATCTTTAAAAAAATATGAATTTACATAATTTAAAAACTTCTAAGTTACTATTCAACTGGACATAAGAAAAAATATTCTTATAGAACAGGGAGAATTTAAAAACTTCTAAGTTACTATTCAACTAGTAAATAAGCTTCTGGACTATAAGTTATATTTTTAATTTAAAAACTTCTAAGTTACTATTCAACTTTTCATGACTTACATTTTCATAATGATTTTCAAATATTTAAAAACTTCTAAGTTACTATTCAACCTAATTGAGTTTCTTTAATTTTTACTTTAAATTTCAATTTAAAAACTTCTAAGTTACTATTCAACTACATTTACACCTCTATACCCTGCAACACCTAAAAAATTTAAAAACTTCTAAGTTACTATTCAACTATGGAAAAAATATTGAATGTGGCTCAGTATATTTTATTTAAAAACTTCTAAGTTACTATTCAACCTAAACATCTTATCTGGAACTGATAATATTTTTTCTATTTAAAAACTTCTAAGTTACTATTCAACATATCTAAATGTTCTAACTTCTTTATTAGAATACCTATTTAAAAACTTCTAAGTTACTATTCAACTAAGTTAGATAAACTAAATAAGATAGAGGATATGCCATTTAAAAACTTCTAAGTTACTATTCAACACCTTCCATTGCTCCTGACTTAGTAGTACATAACCCATTTAAAAACTTCTAAGTTACTATTCAACTAGAAATTAGGAAGATCAGTACTTCTATTGTTCAAATTTAAAAACTTCTAAGTTACTATTCAAC

>LR134390|4|2|1475641-1477224|PILER-CR
ATTTAAAAACTTCTGAGTTACTATTCAAC	TTTGTAACAAATAGCAGTAGCAGTAGTTATATATG
ATTTAAAAACTTCTAAGTTACTATTCAAC	TTTTTCCTAGCAAGAAATATAATTTTATAAGTTGGT
ATTTAAAAACTTCTAAGTTACTATTCAAC	AATTTGAAAAATGAAGTTAGAAAAAATAATACTTTT
ATTTAAAAACTTCTAAGTTACTATTCAAC	CACCTGCACATGAACCATTTTGTTTTATTAATTCC
ATTTAAAAACTTCTAAGTTACTATTCAAC	GATTACAGGATATAAAATATTAGACAAAATAAGAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	GATTACAGGATATAAAATATTAGACAAAATAAGAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAAAATAGATAGTGCAGTAATGGATTTTATTAATGG
ATTTAAAAACTTCTAAGTTACTATTCAAC	AAATTAATTGCATTTTTAAAGTTAAGGGGGTAAAA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TCAAACTTTCAGAGCTGGTACTTTTATATCTGAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	TTGACTACAGAAGAAATGAACCTAAAATTTCAAAA
ATTTAAAAACTTCTAAGTTACTATTCAAC	AGCATACAAAGAAATAATAATGGCTAGAAAGCTGTA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TCTGTTCTTTTTTTTCTTAGCTTTATTTCTCCTTTT
ATTTAAAAACTTCTAAGTTACTATTCAAC	ATCCATGCATCTTTAAAAAAATATGAATTTACATA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TGGACATAAGAAAAAATATTCTTATAGAACAGGGAGA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAGTAAATAAGCTTCTGGACTATAAGTTATATTTTTA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TTTTCATGACTTACATTTTCATAATGATTTTCAAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	CTAATTGAGTTTCTTTAATTTTTACTTTAAATTTCA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TACATTTACACCTCTATACCCTGCAACACCTAAAAA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TATGGAAAAAATATTGAATGTGGCTCAGTATATTTT
ATTTAAAAACTTCTAAGTTACTATTCAAC	CTAAACATCTTATCTGGAACTGATAATATTTTTTCT
ATTTAAAAACTTCTAAGTTACTATTCAAC	ATATCTAAATGTTCTAACTTCTTTATTAGAATACCT
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAAGTTAGATAAACTAAATAAGATAGAGGATATGCC
ATTTAAAAACTTCTAAGTTACTATTCAAC	ACCTTCCATTGCTCCTGACTTAGTAGTACATAACCC
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAGAAATTAGGAAGATCAGTACTTCTATTGTTCAA
ATTTAAAAACTTCTAAGTTACTATTCAAC

>LR134390|4|4|1475641-1477224|CRISPRCasFinder
ATTTAAAAACTTCTGAGTTACTATTCAAC	TTTGTAACAAATAGCAGTAGCAGTAGTTATATATG
ATTTAAAAACTTCTAAGTTACTATTCAAC	TTTTTCCTAGCAAGAAATATAATTTTATAAGTTGGT
ATTTAAAAACTTCTAAGTTACTATTCAAC	AATTTGAAAAATGAAGTTAGAAAAAATAATACTTTT
ATTTAAAAACTTCTAAGTTACTATTCAAC	CACCTGCACATGAACCATTTTGTTTTATTAATTCC
ATTTAAAAACTTCTAAGTTACTATTCAAC	GATTACAGGATATAAAATATTAGACAAAATAAGAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	GATTACAGGATATAAAATATTAGACAAAATAAGAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAAAATAGATAGTGCAGTAATGGATTTTATTAATGG
ATTTAAAAACTTCTAAGTTACTATTCAAC	AAATTAATTGCATTTTTAAAGTTAAGGGGGTAAAA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TCAAACTTTCAGAGCTGGTACTTTTATATCTGAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	TTGACTACAGAAGAAATGAACCTAAAATTTCAAAA
ATTTAAAAACTTCTAAGTTACTATTCAAC	AGCATACAAAGAAATAATAATGGCTAGAAAGCTGTA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TCTGTTCTTTTTTTTCTTAGCTTTATTTCTCCTTTT
ATTTAAAAACTTCTAAGTTACTATTCAAC	ATCCATGCATCTTTAAAAAAATATGAATTTACATA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TGGACATAAGAAAAAATATTCTTATAGAACAGGGAGA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAGTAAATAAGCTTCTGGACTATAAGTTATATTTTTA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TTTTCATGACTTACATTTTCATAATGATTTTCAAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	CTAATTGAGTTTCTTTAATTTTTACTTTAAATTTCA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TACATTTACACCTCTATACCCTGCAACACCTAAAAA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TATGGAAAAAATATTGAATGTGGCTCAGTATATTTT
ATTTAAAAACTTCTAAGTTACTATTCAAC	CTAAACATCTTATCTGGAACTGATAATATTTTTTCT
ATTTAAAAACTTCTAAGTTACTATTCAAC	ATATCTAAATGTTCTAACTTCTTTATTAGAATACCT
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAAGTTAGATAAACTAAATAAGATAGAGGATATGCC
ATTTAAAAACTTCTAAGTTACTATTCAAC	ACCTTCCATTGCTCCTGACTTAGTAGTACATAACCC
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAGAAATTAGGAAGATCAGTACTTCTATTGTTCAA
ATTTAAAAACTTCTAAGTTACTATTCAAC

>LR134390|4|2|1475641-1477224|CRT
ATTTAAAAACTTCTGAGTTACTATTCAAC	TTTGTAACAAATAGCAGTAGCAGTAGTTATATATG
ATTTAAAAACTTCTAAGTTACTATTCAAC	TTTTTCCTAGCAAGAAATATAATTTTATAAGTTGGT
ATTTAAAAACTTCTAAGTTACTATTCAAC	AATTTGAAAAATGAAGTTAGAAAAAATAATACTTTT
ATTTAAAAACTTCTAAGTTACTATTCAAC	CACCTGCACATGAACCATTTTGTTTTATTAATTCC
ATTTAAAAACTTCTAAGTTACTATTCAAC	GATTACAGGATATAAAATATTAGACAAAATAAGAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	GATTACAGGATATAAAATATTAGACAAAATAAGAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAAAATAGATAGTGCAGTAATGGATTTTATTAATGG
ATTTAAAAACTTCTAAGTTACTATTCAAC	AAATTAATTGCATTTTTAAAGTTAAGGGGGTAAAA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TCAAACTTTCAGAGCTGGTACTTTTATATCTGAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	TTGACTACAGAAGAAATGAACCTAAAATTTCAAAA
ATTTAAAAACTTCTAAGTTACTATTCAAC	AGCATACAAAGAAATAATAATGGCTAGAAAGCTGTA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TCTGTTCTTTTTTTTCTTAGCTTTATTTCTCCTTTT
ATTTAAAAACTTCTAAGTTACTATTCAAC	ATCCATGCATCTTTAAAAAAATATGAATTTACATA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TGGACATAAGAAAAAATATTCTTATAGAACAGGGAGA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAGTAAATAAGCTTCTGGACTATAAGTTATATTTTTA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TTTTCATGACTTACATTTTCATAATGATTTTCAAAT
ATTTAAAAACTTCTAAGTTACTATTCAAC	CTAATTGAGTTTCTTTAATTTTTACTTTAAATTTCA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TACATTTACACCTCTATACCCTGCAACACCTAAAAA
ATTTAAAAACTTCTAAGTTACTATTCAAC	TATGGAAAAAATATTGAATGTGGCTCAGTATATTTT
ATTTAAAAACTTCTAAGTTACTATTCAAC	CTAAACATCTTATCTGGAACTGATAATATTTTTTCT
ATTTAAAAACTTCTAAGTTACTATTCAAC	ATATCTAAATGTTCTAACTTCTTTATTAGAATACCT
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAAGTTAGATAAACTAAATAAGATAGAGGATATGCC
ATTTAAAAACTTCTAAGTTACTATTCAAC	ACCTTCCATTGCTCCTGACTTAGTAGTACATAACCC
ATTTAAAAACTTCTAAGTTACTATTCAAC	TAGAAATTAGGAAGATCAGTACTTCTATTGTTCAA
ATTTAAAAACTTCTAAGTTACTATTCAAC

Protein	Signature genes	Signature genes Name	Protein_function
LR134390.1\|VEH39175.1\|1471024_1471462_+\|ACT-domain-containing-protein	unknown	unknown	gnl\|CDD\|179848
LR134390.1\|VEH39182.1\|1480098_1481910_-\|helicase-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|350688
LR134390.1\|VEH39180.1\|1478838_1479321_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
LR134390.1\|VEH39174.1\|1470139_1471015_+\|Homoserine-kinase	unknown	unknown	gnl\|CDD\|234920
LR134390.1\|VEH39171.1\|1467379_1468420_-\|Homoserine-dehydrogenase	unknown	unknown	gnl\|CDD\|235783
LR134390.1\|VEH39179.1\|1477827_1478829_-\|CRISPR-associated-endonuclease-Cas1,-subtype-I-B/HMARI/TNEAP	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
LR134390.1\|VEH39185.1\|1483618_1484353_-\|Uncharacterised-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	unknown
LR134390.1\|VEH39177.1\|1474432_1475554_+\|Transposase-and-inactivated-derivatives	unknown	unknown	gnl\|CDD\|378147
LR134390.1\|VEH39172.1\|1468440_1468551_-\|Uncharacterised-protein	unknown	unknown	gnl\|CDD\|235783
LR134390.1\|VEH39176.1\|1472730_1474227_-\|EIICBA-Glc	unknown	unknown	gnl\|CDD\|273923
LR134390.1\|VEH39178.1\|1477394_1477679_-\|CRISPR-associated-endoribonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
LR134390.1\|VEH39184.1\|1482672_1483626_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458
LR134390.1\|VEH39170.1\|1466038_1467361_-\|Aspartokinase-I/homoserine-dehydrogenase-I	unknown	unknown	gnl\|CDD\|236364
LR134390.1\|VEH39169.1\|1465007_1466027_-\|Aspartate-semialdehyde-dehydrogenase	unknown	unknown	gnl\|CDD\|237845
LR134390.1\|VEH39173.1\|1468664_1470143_+\|Threonine-synthase	unknown	unknown	gnl\|CDD\|236418
LR134390.1\|VEH39186.1\|1484361_1485423_-\|Uncharacterised-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl\|CDD\|188234
LR134390.1\|VEH39187.1\|1485441_1486137_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
LR134390.1\|VEH39168.1\|1464410_1464788_-\|Uncharacterised-protein	unknown	unknown	gnl\|CDD\|238866
LR134390.1\|VEH39183.1\|1481917_1482670_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
LR134390.1\|VEH39181.1\|1479334_1480066_-\|CRISPR-associated-helicase-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224124

Protein	Function_ID	Function_description	E-value
LR134390.1\|VEH39175.1\|1471024_1471462_+\|ACT-domain-containing-protein	gnl\|CDD\|179848	PRK04435, PRK04435, ACT domain-containing protein.	3.92872e-59
LR134390.1\|VEH39182.1\|1480098_1481910_-\|helicase-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	2.80159e-32
LR134390.1\|VEH39180.1\|1478838_1479321_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.33032e-47
LR134390.1\|VEH39174.1\|1470139_1471015_+\|Homoserine-kinase	gnl\|CDD\|234920	PRK01212, PRK01212, homoserine kinase; Provisional.	5.10822e-116
LR134390.1\|VEH39171.1\|1467379_1468420_-\|Homoserine-dehydrogenase	gnl\|CDD\|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	1.67852e-107
LR134390.1\|VEH39179.1\|1477827_1478829_-\|CRISPR-associated-endonuclease-Cas1,-subtype-I-B/HMARI/TNEAP	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	3.07265e-144
LR134390.1\|VEH39177.1\|1474432_1475554_+\|Transposase-and-inactivated-derivatives	gnl\|CDD\|378147	pfam09299, Mu-transpos_C, Mu transposase, C-terminal. Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology.	3.47333e-09
LR134390.1\|VEH39172.1\|1468440_1468551_-\|Uncharacterised-protein	gnl\|CDD\|235783	PRK06349, PRK06349, homoserine dehydrogenase; Provisional.	5.14198e-07
LR134390.1\|VEH39176.1\|1472730_1474227_-\|EIICBA-Glc	gnl\|CDD\|273923	TIGR02002, PTS_system_glucose-specific_IIABC_component, PTS system, glucose-specific IIBC component. This model represents the combined B and C domains of the PTS transport system enzyme II specific for glucose transport. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name "PTS system, glucose-specific IIABC component" while the B. subtilus enzyme also contains an enzyme III domain which appears to act independently of the enzyme II domains. This family is most closely related to the N-acetylglucosamine-specific PTS enzymes (TIGR01998). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids].	0
LR134390.1\|VEH39178.1\|1477394_1477679_-\|CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	7.27656e-26
LR134390.1\|VEH39184.1\|1482672_1483626_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.41973e-48
LR134390.1\|VEH39170.1\|1466038_1467361_-\|Aspartokinase-I/homoserine-dehydrogenase-I	gnl\|CDD\|236364	PRK09034, PRK09034, aspartate kinase; Reviewed.	0
LR134390.1\|VEH39169.1\|1465007_1466027_-\|Aspartate-semialdehyde-dehydrogenase	gnl\|CDD\|237845	PRK14874, PRK14874, aspartate-semialdehyde dehydrogenase; Provisional.	2.3984e-175
LR134390.1\|VEH39173.1\|1468664_1470143_+\|Threonine-synthase	gnl\|CDD\|236418	PRK09225, PRK09225, threonine synthase; Validated.	0
LR134390.1\|VEH39186.1\|1484361_1485423_-\|Uncharacterised-protein	gnl\|CDD\|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	0.00020511
LR134390.1\|VEH39187.1\|1485441_1486137_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	9.844e-14
LR134390.1\|VEH39168.1\|1464410_1464788_-\|Uncharacterised-protein	gnl\|CDD\|238866	cd01828, sialate_O-acetylesterase_like2, sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely resembles the Ser-His-Asp(Glu) triad found in other serine hydrolases.	8.67713e-08
LR134390.1\|VEH39183.1\|1481917_1482670_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.98484e-51
LR134390.1\|VEH39181.1\|1479334_1480066_-\|CRISPR-associated-helicase-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.29147e-08

>LR134390.1|VEH39177.1|1474432_1475554_+|Transposase-and-inactivated-derivatives
MDTEKELQLQRFKIIEPFLRKEKKLKEIEEETGISYATLKRWVNAYKKNGILGLDKKQRTDKDSYRAIDEDGVEYIEQICRESKETKISKLYSFCKEKLSNKYNISYPTFYRIVSNLDGFFNKSSNFHMKKIKKENQVYLILEISLYILVSEEESEHKIVPQLLISLDAATLKPINHALNYNTSSIYTLLSFIRESILKVSYKSSKLIKPQEILVSSENINNKKILKEIYDNTSIKITEYFSENEEIKKFISFLEEDIEKFYYQNNKNLSYQNLKSFLDSYIYLDNQKYDFTLKYGMVENISNVREFDVFLQEASRKISKSSLRFNNFIYTNNFLTTLEGKKVIVKYNPLDTDILYLFFKNQFLGTANIITTG
>LR134390.1|VEH39176.1|1472730_1474227_-|EIICBA-Glc
MKIFAEVQKIGKALMTPVAILPAAGLFLAFGNKLQFTLMEQAGQVIFSNLPLLFAIGAAIGLVGGDGVAALSAVVAILIMNTTMGIISGAAEGIAAGNMSYAMVLGIPTLQTGVFGGLIAGIIAAICYKKFYKTELPAFLGFFAGKRLVPIVTAVAAFIIGLAMPVIWQPVQIGLAKLSYLANETNTNVSTFIFGVIERSLIPFGLHHIFYAPFWYQFGEYTNAAGQVVNGDQAIWFAMLKDGVTNFSSATYQGAGKFLTGKFVFMMFGLPAAALAMYQEAKPANKKLVGGILFSAALTSFLTGITEPLEFSFLFVAPILYGIHCIFAGLSFMLMNMFHVRIGMTFSGGLIDYIAFGVLPGTSGFQNNWYMVIVVGLCLSVVYYFGFRFAIRKFNLMTPGREEAVVESTSASSGSEIKSDELAVGVLEALGGKDNLISLDSCITRLRVEVKDTKIVSDQELKKLGASGVLKVGANGVQAIFGSKAQFICNDLKKMTGI
>LR134390.1|VEH39175.1|1471024_1471462_+|ACT-domain-containing-protein
MKEKYLIVNKKILPDYFEKVVEARNLLTEGKVKGISDAAKIVGISRSTYYKYKDYVFLPSDNSIGRKALVSMMLEHKKGVLSEVLNYLSSVNGNIITINQNIPINDVASVVISLDISDITIPIEDIISGIEQINYVNSTKLLSLE
>LR134390.1|VEH39174.1|1470139_1471015_+|Homoserine-kinase
MITVKVPATTANIGPGFDTLGLAFKLYSYFTFKRIEYGLRIVGCEEKYQNDSNLVYTSFKKTLEILNYPVPGIEISIKSDIPISRGLGSSAACIVGGVMGANIIAGSPLSKDEIFKICNDIEGHPDNIAPALFGGLTASLVEDGIPYTVQYNISENLYFCALVPDFRLSTAEARKVLPSEISYKDAIYNISRTAVLLKALENGDELLIKKSLSDRLHEKYRNVLINEYEEVKEICEKNGNTALFISGSGPTLMNIAKTKDFQWKIEYEIKNLKNSWIIRTLDIDMKGAVVL
>LR134390.1|VEH39173.1|1468664_1470143_+|Threonine-synthase
MNSKFESTREKDITCSASQAVIRGIASDGGLFVRRDMENLKINISELKGKKYTEIAEIILSKVLDDYPEKNIKYCVENAYDKKFNSDDITPLVKVGNDYILELFHGPTSAFKDMALSILPYLSTEALKLNKIKEKILILTATSGDTGKAALEGFKNIEGIKILVFFPNDGVSKVQEKQMITQEGNNTYVYAINGNFDDAQSEVKKIFTDEEIKEKLKKKNYSLSSANSINIGRLVPQIVYYFYSYMKLVERNEIVLGEKVNFTVPTGNFGDILAGYYAELMGLPVNKLICASNENNVLYDFIKTGTYDRNRSFYKTLSPSMDILISSNLERLIYHLSKNDNKYVKHLMAELKSNGKYTVSQEIKNYIDNLFYAGYTTDLQTSETIKNVYNEYNYLLDTHTAVAYNVMKEFKEKDSRHKNIVLATASPYKFSKAVYESLFGENNSDEFKIMELLNEKTKVPIPENLRNLKNKKDIHTSVINKKDMKNCFEVIL
>LR134390.1|VEH39172.1|1468440_1468551_-|Uncharacterised-protein
MKIGLLGFGTVGSGVYEIVKSSPTCFFNDIEIKKFL
>LR134390.1|VEH39171.1|1467379_1468420_-|Homoserine-dehydrogenase
MDIITTDAEEILNDKDIDLVVEVMGGIHPAYEYIMKSLKSKKSVVTANKAVVAAYLKEFTKTAYENGVSFEYEASVCGGIPWIKSLEKAKRIDEINEVYGIFNGTSNFILDNMAKKGYEFQEILKMAQEKGYAESDPSADIDGIDIMRKLLITSSLAFECEIPEKEIDVFGIRNIQKGDIEYFNSIDCTVKLIAKGKKSENRYCASVEPVLFKNDRIEAAVPQNFNIGTICGKTIGELKFYGQGAGKLPTGNAIVQDIIDIMEAKGNLIERKFEKNLIKDSSLISGKYYIRINDKEFEKDNSNIIEKKLEYSGNTIYITKEIDCRTMKQAAEKYLKKDIFYARFEN
>LR134390.1|VEH39170.1|1466038_1467361_-|Aspartokinase-I/homoserine-dehydrogenase-I
MIKVAKFGGSSLADAEQFKKVKKIIENDENRRIVVVSAAGKRFKEDNKITDLLYLCYAHIKYSVSYESMFSIIEKRYLEIRDQLGLKCNLESEFRVIKSRMKKGMNRDYLVSRGEYLAGMLMAEYLGYEFIDAENVIFFDYNGKVDIEKTREAVEKAVERNPKGVIPGFYGTLPNGEIKLFSRGGSDITGAIVSDCIKAAVYENWTDVSGILMADPNIVKDPKRIEIITYSELRELSYMGANVLHTDAVAPAKKANIPINIRNTNAPENPGTIIVDENNELLKNAKNYFITGIAGKKDFSVISIYKDHMSGEIGAIRKVLEIFEKYKVSIEHIPTGIDTFSIVVATENINKYLYEIVADIKRECEPSEVKVIDNISLIATVGRNMADRPGMSGKLFAAIGHSGVNIRMISQGSDEINIIVGVENEDFEKAINVIYNNFVI
>LR134390.1|VEH39169.1|1465007_1466027_-|Aspartate-semialdehyde-dehydrogenase
MRKYNVGILGATGAVGKEMLKVLEERNFPVENIRLFASSRSVGKKMLFKGKEYEIEEAKKGIYKGIDILLGAVENEQAKEFIPSAIENGAIVIDNSSAYRMADDVPLIVPEVNPEAVETHKGLIANPNCATIIGLVAVNELNKYSEVERMIVSTYQAVSGAGSGGISELDAEIKAIAEGKGFAMKIFPYQIAYNLIPQIGGFDEKGYSSEEMKFQNEGRKILNNPKLKVNCTCIRVPVYRSHSESITIEFKDRIDAEKAREILSKAEGVKLVDDPQNKKYPMPLDTSDQDLVYVGRIREDISNDEGKGLTLWCCGDQVRKGAATNAVQIAELLIKKEMI
>LR134390.1|VEH39168.1|1464410_1464788_-|Uncharacterised-protein
MALEKIVMLGDSIIDWNHSSKYINYGHAGFKTRDVLWLLEEKSEIKGDIGILLVGVNDILCGFKEEYTLEYYNKTVELLKQRFKKLILLSMLPSDTPRINIKSKMLNIKLKNLYNEDFLIFIIYF
>LR134390.1|VEH39178.1|1477394_1477679_-|CRISPR-associated-endoribonuclease-Cas2
MKGKNYNYVFLFYDINEKRVNKVFKICKKYLSHHQRSVFRGEITPSNLIKMRLELKDVIDKKEDFISIVKLISEHYFDEEIIGTPWKDDENIFI
>LR134390.1|VEH39179.1|1477827_1478829_-|CRISPR-associated-endonuclease-Cas1,-subtype-I-B/HMARI/TNEAP
MGAGTKYILSKGTLERKDNSLCFKNESKTTYIPIEGVKEIFALDEISVNTKLFDFLAKHGIVLHFFNHYEGYSGTFYPREKYVSGKLVIKQVEAHKLYKEKIAKSIINGIGKNIYELLYHYYRHDKKELKEYLDWLSNEVEERLNKSSDINEIMAVEGEIWAKFYDSFKIFLREDFILNKRVKRPPDNPINALISFGNSILYTKTIGQIYQTHLEQTISFLHSPSERRFSLSLDLSEVFKPIIVFRTIFDCVNNRKLNVEKHFEKSLNYCILNEDGKKIFLGALEDRMNETFEHPILKRKVSYITAIKYDAYKLIKFILENKEFIPFYMKEKM
>LR134390.1|VEH39180.1|1478838_1479321_-|CRISPR-associated-protein-Cas4
MPINGTIINYYIHCKRQCYMHYNRINMEDESELVKIGKAMHEEKNTEEITVDNIKVDKIKKDYLIEIKKSDADIEAAKMQVLYYLLKLKEKGIVKKGKIEVIEKNKSSRKSYEIELTAENELHIKNIMEEIEKLVKEDELPPIEKNNKCKKCAYYSYCYI
>LR134390.1|VEH39181.1|1479334_1480066_-|CRISPR-associated-helicase-Cas3
MILVATQVIEAGVDIDMDIGFKNISILDADEQFLGRINRSCKKKNCKVYFFKLDDGGKIYKSDVRIQGRFTLMNEEMREILKSKNFSEYYSKILEVLDDFSNKEDEENIENFRRNKVVQLNFEEINKRLKLITDEMKTKMIFFSRNIKIEGEEIEGNKVWKEFKEVFLNNEIGYAERRVKLSKVMEKVDLFSYNIPKEMTYRLSYQDSIGDNILYIQDGEEYFVNGKFDRKKMQSKNDCEMIL
>LR134390.1|VEH39182.1|1480098_1481910_-|helicase-Cas3
MFEEELFSIEKYVKDENKVLAHISDIKNPETLLEHSDLVIKYFKKIYEDKNLKIIFDKLADKFWRENESTKKFWNEMIVNTIYMHDIGKLNINFQIDKMKNKIFDRKHLYQSKRHSNLSARIYIDHFGNKVFKLYSEKKLDNKTALKCFIFIILNSYIISRHHSSTKSLSEDFFNEIIKDYEEYKELFEEVNNYCPNLNFLIKESKNLFRILKQLKIGEKEWNNSIETKDWESVDYYIYTKLLYSLLVSSDFYATSEYSSGKPIESLNLLTNIDEYISVFNNTDIYKGIKLHQKTGKIFSKDNINYYRSEMFLEAEQNLGKNIKENILFLEAPTGSGKTITSINLALKLLEKNRELNKIFYIFPFNTLVEQTNASLREIFQGSFLEENISVINSITPIKEVENEDGRAQIDYERSLLNRQFIHSPIVLTTHVHFFENLFGIDRESSFALPHLANSVVIMDEIQSYKNKIWKEIIIFLKKYAEILNIKIIIMSATLPNLSFLLNSEAQIPSLVINKEKYYRNPIFKDRVSLDFSLLEKEYEKEELFDQIEKIILEKYRDKKVVVEFIKKSSAFDFYKRLVEKNEDSKEDIFLITGDDNKAERKK
>LR134390.1|VEH39183.1|1481917_1482670_-|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)
MEILKFTLSGRTAFFKIPEVNSYVYFSYGHIHKVSLLGLLGAVMGYEGYNSQGEKEFPEFYEKLKDIKISIMPKNTNGSFSKKIQIFNNSVGYASNEEGGNLIVKEQWLEDVEWDIFIKMEDTDIHKELKERMENYKFEYTIYLGKNDHLATINNVEVLQGESFLEDESEINSLFLRKDIEGFLEEEFNILGSEEDEIKYDYKYEEKLPISLDSISNQYKVESLIFTNKKCILKDKSNFAKINNQIIEFY
>LR134390.1|VEH39184.1|1482672_1483626_-|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair
MNNYENRVYGIIGVKSIMANWNADFEGYPKTISSGETFGSDKALKYPMKKMWEAEGEKVLYIKSLKVDSGEGKKGEIAVRPKSLRERYDEIFETNLKEEKDKTNVIKNLFKAIDVKNFGATFAEEKNNASITGAVQIGQGFNKYVDTYPEEQQILSPFRDSSKDEKEGEANQSTLGTKIVSNEAHYFYPFVINPQVYKDFVKMGMTEGYTEEDYKKFKDAALTSATFFNSNSKLGCENEFALFIEVKEGYYLPELAQYVKFSKEKDYDVIELGFDELINQFKDNILSVEIYYNTLNVKVKHNIKGAKEYNIFTRKEV
>LR134390.1|VEH39185.1|1483618_1484353_-|Uncharacterised-protein
MNNLLFNGKLYGIIFENSKDLKIYDERVKNIVNQYKETFFKLIYKGELNAFFKSCENIFLELIKNYLFKNENKYPAYDMFNLMVSIEESLINKGEKTMDNYQKMKTKFREVLKTNEGIIENDDEFFYVVGQIVDYFISLNRTTEKTHKLINPILKVNNRKRLDQNLETMYKKYNYAIKRYEKENKDKSKMKFDKLFSLLSLYELENENINERNKRLIIGGYLSESLIYEKTDKENKDINGKENE
>LR134390.1|VEH39186.1|1484361_1485423_-|Uncharacterised-protein
MLRECVEIFTEIYNQKGERFITDSYELEPGDYFIVKSDGSYSHIKIERRKKSEENLNRRTIEDYEYLAERDYLSRLLDMNKPIDGKKQIHSNNYLSFFVKNNVLSEKKKELEESMEKYYEILKNPFLKYDKGEKKRVYTQLEEKLGKPSEEKIQKNQEWIKTNLYKIKEEIKAGKEYIKIFFDEDIKEYKKESERYIIPNIYNSIDYNVIIDNETYGLPNNNLNLNSKKPYLENKTRKKKYTVPYLLNEEEVFEQKKFFDYLYNMSNSGKRNIYISPDKKEIIPLKDSEFLDNNFTGYYLRIRKDKSESAVERYEIISDYRAEIYPEIKILDCLGNGDKGKLEYGSSIKRILN
>LR134390.1|VEH39187.1|1485441_1486137_-|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)
MESWVLELKVFLLEDIESHSAIEKIAALIDSTFDKSEYWKKYHKDKKVKEYCFNSFYPVKVNAQKYNAGEIYTVQIRTISKELKEHFMKYLKDNITKELKGLIIKEKEIKYRYIDKLVSVTPTIIKTENGYWRENITLEEYENRLKLNIIKKYNSIFNEKIDENIDLFNFIEFKNKVPVKVKYKNINLLGDKLTLGIAKNETAQKLAFLCLSVGLGEMNARGFSYMNPRWV

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Crispr_ID: LR134390_5

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

LR134390_5

1486265-1487072

TypeI-B

Consensus_repeat	Method
ATTTAAAAACTACCAAGTTACTATTCAAC	CRT
ATTTAAAAACTACCAAGTTACTATTCAAC	PILER-CR
ATTTAAAAACTACCAAGTTACTATTCAAC	CRISPRCasFinder

12 spacers

cas6,cas8b1,cas7b,cas5,cas3,cas4,cas1,cas2

The CRISPR arrays of LR134390_5

>merge|LR134390|5|1486265-1487072|CRT,PILER-CR,CRISPRCasFinder
AAAATTTTTATTATAAGTTACTATTCAACTGTAAAATCAATCATATAAAGACTCTCGACTTTGCTATTTAAAAACTACCAAGTTACTATTCAACTTTGATAAGAGGAGAGAGAGCTATTTTTTAAATATATTTAAAAACTACCAAGTTACTATTCAACCAGGTGAACATTTTGATAAAGTTTATGAGGAATACAAATTTAAAAACTACCAAGTTACTATTCAACAATGACTATAGGTTCTATATAAACTTAAAATTTTAAATTTAAAAACTACCAAGTTACTATTCAACTGGAATAAAAGGAAGTATGGCTGGAACATCTTTAAAATTTAAAAACTACCAAGTTACTATTCAACTTTTTTAAGTGCATTTTAAGTGCAAAAATATAAAGAATTTAAAAACTACCAAGTTACTATTCAACTTTTTTAAGTGCATTTTAAGTGCAAAAATATAAAGAATTTAAAAACTACCAAGTTACTATTCAACAGAAACAATTCATCTATTTTTTCACTTTTATTAGAATTTAAAAACTACCAAGTTACTATTCAACAGAAACAATTCATCTATTTTTTCACTTTTATTAGAATTTAAAAACTACCAAGTTACTATTCAACTATTTACACTAATTTTTAAATTTATCAAAATATTTTATTTAAAAACTACCAAGTTACTATTCAACAGGAAAACAACAAGAGCTTTTAAAAGAAGCTTTTTTAATTTAAAAACTACCAAGTTACTATTCAACTGTTAGTTTTGCTTTTAATGTAGGAACTAAAGCATTATTTAAAAACTACCAAGTTACTATTCAAC

>LR134390|5|3|1486265-1487072|CRT
AAAATTTTTATTATAAGTTACTATTCAAC	TGTAAAATCAATCATATAAAGACTCTCGACTTTGCT
ATTTAAAAACTACCAAGTTACTATTCAAC	TTTGATAAGAGGAGAGAGAGCTATTTTTTAAATAT
ATTTAAAAACTACCAAGTTACTATTCAAC	CAGGTGAACATTTTGATAAAGTTTATGAGGAATACAA
ATTTAAAAACTACCAAGTTACTATTCAAC	AATGACTATAGGTTCTATATAAACTTAAAATTTTAA
ATTTAAAAACTACCAAGTTACTATTCAAC	TGGAATAAAAGGAAGTATGGCTGGAACATCTTTAAA
ATTTAAAAACTACCAAGTTACTATTCAAC	TTTTTTAAGTGCATTTTAAGTGCAAAAATATAAAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	TTTTTTAAGTGCATTTTAAGTGCAAAAATATAAAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	AGAAACAATTCATCTATTTTTTCACTTTTATTAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	AGAAACAATTCATCTATTTTTTCACTTTTATTAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	TATTTACACTAATTTTTAAATTTATCAAAATATTTT
ATTTAAAAACTACCAAGTTACTATTCAAC	AGGAAAACAACAAGAGCTTTTAAAAGAAGCTTTTTTA
ATTTAAAAACTACCAAGTTACTATTCAAC	TGTTAGTTTTGCTTTTAATGTAGGAACTAAAGCATT
ATTTAAAAACTACCAAGTTACTATTCAAC

>LR134390|5|3|1486330-1487072|PILER-CR
ATTTAAAAACTACCAAGTTACTATTCAAC	TTTGATAAGAGGAGAGAGAGCTATTTTTTAAATAT
ATTTAAAAACTACCAAGTTACTATTCAAC	CAGGTGAACATTTTGATAAAGTTTATGAGGAATACAA
ATTTAAAAACTACCAAGTTACTATTCAAC	AATGACTATAGGTTCTATATAAACTTAAAATTTTAA
ATTTAAAAACTACCAAGTTACTATTCAAC	TGGAATAAAAGGAAGTATGGCTGGAACATCTTTAAA
ATTTAAAAACTACCAAGTTACTATTCAAC	TTTTTTAAGTGCATTTTAAGTGCAAAAATATAAAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	TTTTTTAAGTGCATTTTAAGTGCAAAAATATAAAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	AGAAACAATTCATCTATTTTTTCACTTTTATTAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	AGAAACAATTCATCTATTTTTTCACTTTTATTAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	TATTTACACTAATTTTTAAATTTATCAAAATATTTT
ATTTAAAAACTACCAAGTTACTATTCAAC	AGGAAAACAACAAGAGCTTTTAAAAGAAGCTTTTTTA
ATTTAAAAACTACCAAGTTACTATTCAAC	TGTTAGTTTTGCTTTTAATGTAGGAACTAAAGCATT
ATTTAAAAACTACCAAGTTACTATTCAAC

>LR134390|5|5|1486330-1487072|CRISPRCasFinder
ATTTAAAAACTACCAAGTTACTATTCAAC	TTTGATAAGAGGAGAGAGAGCTATTTTTTAAATAT
ATTTAAAAACTACCAAGTTACTATTCAAC	CAGGTGAACATTTTGATAAAGTTTATGAGGAATACAA
ATTTAAAAACTACCAAGTTACTATTCAAC	AATGACTATAGGTTCTATATAAACTTAAAATTTTAA
ATTTAAAAACTACCAAGTTACTATTCAAC	TGGAATAAAAGGAAGTATGGCTGGAACATCTTTAAA
ATTTAAAAACTACCAAGTTACTATTCAAC	TTTTTTAAGTGCATTTTAAGTGCAAAAATATAAAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	TTTTTTAAGTGCATTTTAAGTGCAAAAATATAAAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	AGAAACAATTCATCTATTTTTTCACTTTTATTAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	AGAAACAATTCATCTATTTTTTCACTTTTATTAGA
ATTTAAAAACTACCAAGTTACTATTCAAC	TATTTACACTAATTTTTAAATTTATCAAAATATTTT
ATTTAAAAACTACCAAGTTACTATTCAAC	AGGAAAACAACAAGAGCTTTTAAAAGAAGCTTTTTTA
ATTTAAAAACTACCAAGTTACTATTCAAC	TGTTAGTTTTGCTTTTAATGTAGGAACTAAAGCATT
ATTTAAAAACTACCAAGTTACTATTCAAC

Protein	Signature genes	Signature genes Name	Protein_function
LR134390.1\|VEH39193.1\|1490547_1490748_-\|Uncharacterised-protein	unknown	unknown	unknown
LR134390.1\|VEH39183.1\|1481917_1482670_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)	cas5	cls001430_cas5_CAS-I-B	gnl\|CDD\|131641
LR134390.1\|VEH39182.1\|1480098_1481910_-\|helicase-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|350688
LR134390.1\|VEH39180.1\|1478838_1479321_-\|CRISPR-associated-protein-Cas4	cas4	pfam01930_cas4_CAS-I	gnl\|CDD\|366863
LR134390.1\|VEH39181.1\|1479334_1480066_-\|CRISPR-associated-helicase-Cas3	cas3	cd09639_cas3_CAS-I	gnl\|CDD\|224124
LR134390.1\|VEH39179.1\|1477827_1478829_-\|CRISPR-associated-endonuclease-Cas1,-subtype-I-B/HMARI/TNEAP	cas1	cd09722_cas1_CAS-I-B	gnl\|CDD\|187853
LR134390.1\|VEH39188.1\|1487245_1487869_-\|Uncharacterised-protein	unknown	unknown	unknown
LR134390.1\|VEH39190.1\|1488600_1489029_-\|Uncharacterized-N-acetyltransferase-YjaB	unknown	unknown	gnl\|CDD\|236715
LR134390.1\|VEH39192.1\|1489633_1490473_-\|chromosome-segregation-protein	unknown	unknown	gnl\|CDD\|235175
LR134390.1\|VEH39191.1\|1489021_1489207_-\|Uncharacterised-protein	unknown	unknown	gnl\|CDD\|270872
LR134390.1\|VEH39194.1\|1490902_1491094_-\|Uncharacterised-protein	unknown	unknown	unknown
LR134390.1\|VEH39178.1\|1477394_1477679_-\|CRISPR-associated-endoribonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl\|CDD\|187856
LR134390.1\|VEH39189.1\|1487865_1488522_-\|Uncharacterized-BCR,-COG1636	unknown	unknown	gnl\|CDD\|376894
LR134390.1\|VEH39185.1\|1483618_1484353_-\|Uncharacterised-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	unknown
LR134390.1\|VEH39196.1\|1492112_1492424_-\|Probable-DNA-double-strand-break-repair-Rad50-ATPase	unknown	unknown	gnl\|CDD\|213207
LR134390.1\|VEH39195.1\|1491155_1491872_-\|Uncharacterised-protein	unknown	unknown	gnl\|CDD\|274009
LR134390.1\|VEH39197.1\|1492410_1493625_-\|exonuclease-SbcCD,-D-subunit	unknown	unknown	gnl\|CDD\|223497
LR134390.1\|VEH39186.1\|1484361_1485423_-\|Uncharacterised-protein	cas8b1	mkCas0106_cas8b1_CAS-I-B	gnl\|CDD\|188234
LR134390.1\|VEH39187.1\|1485441_1486137_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)	cas6	cd09652_cas6_CAS-I:CAS-III	gnl\|CDD\|273848
LR134390.1\|VEH39184.1\|1482672_1483626_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl\|CDD\|377458

Protein	Function_ID	Function_description	E-value
LR134390.1\|VEH39183.1\|1481917_1482670_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)	gnl\|CDD\|131641	TIGR02592, hypothetical_protein_CTC_01466, CRISPR-associated protein Cas5, subtype I-B/HMARI. This is a CRISPR-associated protein unique to the hmari subtype of cas genes and CRISPR repeat, which is the only subtype present in Haloarcula marismortui ATCC 43049. The hmari type, though uncommon, is also found in the Aquificae, Thermotogae, Firmicutes, and Dictyoglomi.	2.98484e-51
LR134390.1\|VEH39182.1\|1480098_1481910_-\|helicase-Cas3	gnl\|CDD\|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	2.80159e-32
LR134390.1\|VEH39180.1\|1478838_1479321_-\|CRISPR-associated-protein-Cas4	gnl\|CDD\|366863	pfam01930, Cas_Cas4, Domain of unknown function DUF83. This domain has no known function. The domain contains three conserved cysteines at its C-terminus.	1.33032e-47
LR134390.1\|VEH39181.1\|1479334_1480066_-\|CRISPR-associated-helicase-Cas3	gnl\|CDD\|224124	COG1203, COG1203, CRISPR-associated helicase Cas3 [Defense mechanisms].	2.29147e-08
LR134390.1\|VEH39179.1\|1477827_1478829_-\|CRISPR-associated-endonuclease-Cas1,-subtype-I-B/HMARI/TNEAP	gnl\|CDD\|187853	cd09722, Cas1_I-B, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	3.07265e-144
LR134390.1\|VEH39195.1\|1491155_1491872_-\|Uncharacterised-protein	gnl\|CDD\|274009	TIGR02169, chromosome_segregation_protein_related_ptotein, chromosome segregation protein SMC, primarily archaeal type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	6.74263e-06
LR134390.1\|VEH39192.1\|1489633_1490473_-\|chromosome-segregation-protein	gnl\|CDD\|235175	PRK03918, PRK03918, DNA double-strand break repair ATPase Rad50.	2.69215e-18
LR134390.1\|VEH39191.1\|1489021_1489207_-\|Uncharacterised-protein	gnl\|CDD\|270872	cd13970, ABC1_ADCK3, Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3. This subfamily is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Subfamily 13 (ABC1K13) of plant ABC1 kinases belongs in this subfamily with yeast Abc1p and human ADCK3. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.	0.00142601
LR134390.1\|VEH39178.1\|1477394_1477679_-\|CRISPR-associated-endoribonuclease-Cas2	gnl\|CDD\|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	7.27656e-26
LR134390.1\|VEH39189.1\|1487865_1488522_-\|Uncharacterized-BCR,-COG1636	gnl\|CDD\|376894	pfam02677, DUF208, Uncharacterized BCR, COG1636.	6.13685e-96
LR134390.1\|VEH39184.1\|1482672_1483626_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair	gnl\|CDD\|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	1.41973e-48
LR134390.1\|VEH39196.1\|1492112_1492424_-\|Probable-DNA-double-strand-break-repair-Rad50-ATPase	gnl\|CDD\|213207	cd03240, ABC_Rad50, ATP-binding cassette domain of Rad50. The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.	4.51579e-19
LR134390.1\|VEH39197.1\|1492410_1493625_-\|exonuclease-SbcCD,-D-subunit	gnl\|CDD\|223497	COG0420, SbcD, DNA repair exonuclease [DNA replication, recombination, and repair].	1.00953e-28
LR134390.1\|VEH39186.1\|1484361_1485423_-\|Uncharacterised-protein	gnl\|CDD\|188234	TIGR02591, cas_Csh1, CRISPR-associated protein Cas8b/Csh1, subtype I-B/HMARI. This domain is found in the C-terminal 2/3 of a family of CRISPR associated proteins of the Hmari subtype. Except for the two sequences from halophilic archaea this domain contains a pair of CXXC motifs.	0.00020511
LR134390.1\|VEH39187.1\|1485441_1486137_-\|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)	gnl\|CDD\|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	9.844e-14
LR134390.1\|VEH39190.1\|1488600_1489029_-\|Uncharacterized-N-acetyltransferase-YjaB	gnl\|CDD\|236715	PRK10562, PRK10562, putative acetyltransferase; Provisional.	1.02729e-45

>LR134390.1|VEH39187.1|1485441_1486137_-|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)
MESWVLELKVFLLEDIESHSAIEKIAALIDSTFDKSEYWKKYHKDKKVKEYCFNSFYPVKVNAQKYNAGEIYTVQIRTISKELKEHFMKYLKDNITKELKGLIIKEKEIKYRYIDKLVSVTPTIIKTENGYWRENITLEEYENRLKLNIIKKYNSIFNEKIDENIDLFNFIEFKNKVPVKVKYKNINLLGDKLTLGIAKNETAQKLAFLCLSVGLGEMNARGFSYMNPRWV
>LR134390.1|VEH39186.1|1484361_1485423_-|Uncharacterised-protein
MLRECVEIFTEIYNQKGERFITDSYELEPGDYFIVKSDGSYSHIKIERRKKSEENLNRRTIEDYEYLAERDYLSRLLDMNKPIDGKKQIHSNNYLSFFVKNNVLSEKKKELEESMEKYYEILKNPFLKYDKGEKKRVYTQLEEKLGKPSEEKIQKNQEWIKTNLYKIKEEIKAGKEYIKIFFDEDIKEYKKESERYIIPNIYNSIDYNVIIDNETYGLPNNNLNLNSKKPYLENKTRKKKYTVPYLLNEEEVFEQKKFFDYLYNMSNSGKRNIYISPDKKEIIPLKDSEFLDNNFTGYYLRIRKDKSESAVERYEIISDYRAEIYPEIKILDCLGNGDKGKLEYGSSIKRILN
>LR134390.1|VEH39185.1|1483618_1484353_-|Uncharacterised-protein
MNNLLFNGKLYGIIFENSKDLKIYDERVKNIVNQYKETFFKLIYKGELNAFFKSCENIFLELIKNYLFKNENKYPAYDMFNLMVSIEESLINKGEKTMDNYQKMKTKFREVLKTNEGIIENDDEFFYVVGQIVDYFISLNRTTEKTHKLINPILKVNNRKRLDQNLETMYKKYNYAIKRYEKENKDKSKMKFDKLFSLLSLYELENENINERNKRLIIGGYLSESLIYEKTDKENKDINGKENE
>LR134390.1|VEH39184.1|1482672_1483626_-|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair
MNNYENRVYGIIGVKSIMANWNADFEGYPKTISSGETFGSDKALKYPMKKMWEAEGEKVLYIKSLKVDSGEGKKGEIAVRPKSLRERYDEIFETNLKEEKDKTNVIKNLFKAIDVKNFGATFAEEKNNASITGAVQIGQGFNKYVDTYPEEQQILSPFRDSSKDEKEGEANQSTLGTKIVSNEAHYFYPFVINPQVYKDFVKMGMTEGYTEEDYKKFKDAALTSATFFNSNSKLGCENEFALFIEVKEGYYLPELAQYVKFSKEKDYDVIELGFDELINQFKDNILSVEIYYNTLNVKVKHNIKGAKEYNIFTRKEV
>LR134390.1|VEH39183.1|1481917_1482670_-|Uncharacterized-protein-predicted-to-be-involved-in-DNA-repair-(RAMP-superfamily)
MEILKFTLSGRTAFFKIPEVNSYVYFSYGHIHKVSLLGLLGAVMGYEGYNSQGEKEFPEFYEKLKDIKISIMPKNTNGSFSKKIQIFNNSVGYASNEEGGNLIVKEQWLEDVEWDIFIKMEDTDIHKELKERMENYKFEYTIYLGKNDHLATINNVEVLQGESFLEDESEINSLFLRKDIEGFLEEEFNILGSEEDEIKYDYKYEEKLPISLDSISNQYKVESLIFTNKKCILKDKSNFAKINNQIIEFY
>LR134390.1|VEH39182.1|1480098_1481910_-|helicase-Cas3
MFEEELFSIEKYVKDENKVLAHISDIKNPETLLEHSDLVIKYFKKIYEDKNLKIIFDKLADKFWRENESTKKFWNEMIVNTIYMHDIGKLNINFQIDKMKNKIFDRKHLYQSKRHSNLSARIYIDHFGNKVFKLYSEKKLDNKTALKCFIFIILNSYIISRHHSSTKSLSEDFFNEIIKDYEEYKELFEEVNNYCPNLNFLIKESKNLFRILKQLKIGEKEWNNSIETKDWESVDYYIYTKLLYSLLVSSDFYATSEYSSGKPIESLNLLTNIDEYISVFNNTDIYKGIKLHQKTGKIFSKDNINYYRSEMFLEAEQNLGKNIKENILFLEAPTGSGKTITSINLALKLLEKNRELNKIFYIFPFNTLVEQTNASLREIFQGSFLEENISVINSITPIKEVENEDGRAQIDYERSLLNRQFIHSPIVLTTHVHFFENLFGIDRESSFALPHLANSVVIMDEIQSYKNKIWKEIIIFLKKYAEILNIKIIIMSATLPNLSFLLNSEAQIPSLVINKEKYYRNPIFKDRVSLDFSLLEKEYEKEELFDQIEKIILEKYRDKKVVVEFIKKSSAFDFYKRLVEKNEDSKEDIFLITGDDNKAERKK
>LR134390.1|VEH39181.1|1479334_1480066_-|CRISPR-associated-helicase-Cas3
MILVATQVIEAGVDIDMDIGFKNISILDADEQFLGRINRSCKKKNCKVYFFKLDDGGKIYKSDVRIQGRFTLMNEEMREILKSKNFSEYYSKILEVLDDFSNKEDEENIENFRRNKVVQLNFEEINKRLKLITDEMKTKMIFFSRNIKIEGEEIEGNKVWKEFKEVFLNNEIGYAERRVKLSKVMEKVDLFSYNIPKEMTYRLSYQDSIGDNILYIQDGEEYFVNGKFDRKKMQSKNDCEMIL
>LR134390.1|VEH39180.1|1478838_1479321_-|CRISPR-associated-protein-Cas4
MPINGTIINYYIHCKRQCYMHYNRINMEDESELVKIGKAMHEEKNTEEITVDNIKVDKIKKDYLIEIKKSDADIEAAKMQVLYYLLKLKEKGIVKKGKIEVIEKNKSSRKSYEIELTAENELHIKNIMEEIEKLVKEDELPPIEKNNKCKKCAYYSYCYI
>LR134390.1|VEH39179.1|1477827_1478829_-|CRISPR-associated-endonuclease-Cas1,-subtype-I-B/HMARI/TNEAP
MGAGTKYILSKGTLERKDNSLCFKNESKTTYIPIEGVKEIFALDEISVNTKLFDFLAKHGIVLHFFNHYEGYSGTFYPREKYVSGKLVIKQVEAHKLYKEKIAKSIINGIGKNIYELLYHYYRHDKKELKEYLDWLSNEVEERLNKSSDINEIMAVEGEIWAKFYDSFKIFLREDFILNKRVKRPPDNPINALISFGNSILYTKTIGQIYQTHLEQTISFLHSPSERRFSLSLDLSEVFKPIIVFRTIFDCVNNRKLNVEKHFEKSLNYCILNEDGKKIFLGALEDRMNETFEHPILKRKVSYITAIKYDAYKLIKFILENKEFIPFYMKEKM
>LR134390.1|VEH39178.1|1477394_1477679_-|CRISPR-associated-endoribonuclease-Cas2
MKGKNYNYVFLFYDINEKRVNKVFKICKKYLSHHQRSVFRGEITPSNLIKMRLELKDVIDKKEDFISIVKLISEHYFDEEIIGTPWKDDENIFI
>LR134390.1|VEH39188.1|1487245_1487869_-|Uncharacterised-protein
MKNFSEKTVKNISICFLLLFLLLGLNHHYYFALMIIPIMIYFSTWKVVMFEDRIGRFSPIVIGLLLSAFIFYCQYYLQGEVVSTKEVIALKGTISFCIGMWLGSFIAKYIYMRIKFFINRIGSKGEQKEYKIIKMIIDQKRYFKKPGSKYYINFYYLIADVNGEEVKFLIEKEFYDKYLGKKSMNINIKKGSLGIFYGINLVDLETK
>LR134390.1|VEH39189.1|1487865_1488522_-|Uncharacterized-BCR,-COG1636
MMKINYDLVMEKQLEEIEKNKIKPKLLLHSCCAPCSSAILEFLQEYFEITVYFFNPNITFQEEYMKRLEEQKEYHKKRGYQINVIEGRYNSEIDFFQSIKGLENEKEGGKRCHQCYRIRLEETAKKAKEDGYEYFTTVLSISPMKNAQWINEIGEELEKEYGIKFLNGDFKKKSRYLKSIEISKEYELYRQDYCGCIFSKLEREKNEKEKRENNGGER
>LR134390.1|VEH39190.1|1488600_1489029_-|Uncharacterized-N-acetyltransferase-YjaB
MIRNLKNDDIDIVMELWKDSTIEAQNFIPDSYWLENYDNVKNNYLPNSDTYVYEEDGEIKGFVSLIENIFIGGLFIRVDSQREGIGSVILDFLKERNDKLQLTVYDKNERAMKFYLKSGFKILNTEIDKKTREKEHLMEWRR
>LR134390.1|VEH39191.1|1489021_1489207_-|Uncharacterised-protein
MGDDEKMSNGEIEKLEKMIDELKEELHECDYEPERNALLKKYKRLTVQMEELKKLKRKKND
>LR134390.1|VEH39192.1|1489633_1490473_-|chromosome-segregation-protein
MITINTNIDKLEKKTNSLERSSNLYLENYKKAMEKNELEKNLENIKIIIENNQMKFKEKSTLLELKRKDIESIELEKIQKKDEEITSDIEEIREKLGAVNSEVETLKKKLDEVKKYEDLLKNKRKYLEKLNMKLELTKIFREKIKSMGKEVSKNMLKEIEILATENFRKITGRGEKIVWSNEDKNKYVVFLDGDRGELKFEQLSGGEQVAVAISIRGAMSELFTESKFSIFDEPTNNLDTERRRSLADSIGEILKNLEQSIIVTHDDTFREMAQKVIEL
>LR134390.1|VEH39193.1|1490547_1490748_-|Uncharacterised-protein
MKLKNFKLENNIESKEKLSEIKITLKTKIDSLDLLKSEEIKGGLEKEIENLNKNINIELKNIEEKK
>LR134390.1|VEH39194.1|1490902_1491094_-|Uncharacterised-protein
MEDEILKKDLLLKENEEAFEMLKTSYCPYLKEQCKNLDGKNIDEYFKDKREKYIKEIEEKKIL
>LR134390.1|VEH39195.1|1491155_1491872_-|Uncharacterised-protein
MENIAEIMEDPADIKEKLEFEKGRAKEYNSSLALLNEEKSKVKEFLNSYNALNIEIEKLTGEINALSESIKNKNEEFTKVANSIKESEISEKIVKENREKYEEYQKYSQEINILKIRKKELEKIKEECLLYEKEINSLEKLNSEIDGEIKVFENKKENNESLLLERKNKLFEIEKEIIDKKGKSVEYKSELSKITPLLIKLEEFEKKLEVGENNIKNFEIKLEEKLEDINKEKEKENI
>LR134390.1|VEH39196.1|1492112_1492424_-|Probable-DNA-double-strand-break-repair-Rad50-ATPase
MKINRIHLENYRIHDKLDVEFDSGINLLLGENGKGKSSILEAIGYALFDSELRGGNQREAIKYGKKSAKIEIEFTGIDGEDYIVTRKIPGSTSIYKKIIQIFN
>LR134390.1|VEH39197.1|1492410_1493625_-|exonuclease-SbcCD,-D-subunit
MNLKIIAEENKNENTSLLRYTSREKTFWNKRIFSKEIFGFFYAFEQAADRGIEKKVDIFLITGDLFDKKELSPDTLDRCEKVFLKLKNNNIQALLIEGNHDNISGYDEINSWLGYLERKGYVRRGKYKASNDGYEFEKITIEDVNFYGVGYPGFAVDEVLEKLSENLNENEKNIVMVHTALGGSEFLPGLVNTDIIKKFKDKVIYMAGGHLHSFVSYPKDKPYFFIPGSTEFWNVLNEKNNSKGVIIFDTDTLEYEFSELSPRKRIEKEFTYEKDITLEFEEFSKNLELTGEELVIVNVKLKDSGYVNVNELEKILESNGALKGYIKLRYPNSIFDRNLGEEGYYSVRDVEREIINCWEEFSDAEKITSYLQKFKEYQEENDREKDFFELFDAMLEEEIGDENK

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Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity
LR134390_8	8.1\|1843679\|27\|LR134390\|PILER-CR	1843679-1843705	27	LR134390.1	1843601-1843627	0	1.0
LR134390_11	11.1\|2932220\|53\|LR134390\|CRISPRCasFinder	2932220-2932272	53	LR134390.1	1875251-1875303	0	1.0

1. spacer 8.1|1843679|27|LR134390|PILER-CR matches to position: 1843601-1843627, mismatch: 0, identity: 1.0

agtaccagtaccacttattgttccttt	CRISPR spacer
agtaccagtaccacttattgttccttt	Protospacer
***************************

2. spacer 11.1|2932220|53|LR134390|CRISPRCasFinder matches to position: 1875251-1875303, mismatch: 0, identity: 1.0

gttatagctcctacatttactaggtttcctgttcctacaagttcaacattttg	CRISPR spacer
gttatagctcctacatttactaggtttcctgttcctacaagttcaacattttg	Protospacer
*****************************************************

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
LR134390_8	8.1\|1843679\|27\|LR134390\|PILER-CR	1843679-1843705	27	MN694200	Marine virus AFVG_250M858, complete genome	11775-11801	4	0.852
LR134390_8	8.1\|1843679\|27\|LR134390\|PILER-CR	1843679-1843705	27	MN693492	Marine virus AFVG_25M361, complete genome	20041-20067	5	0.815
LR134390_8	8.1\|1843679\|27\|LR134390\|PILER-CR	1843679-1843705	27	AP014044	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C12-MedDCM-OCT-S24-C146, * SEQUENCING IN PROGRESS *	5772-5798	5	0.815
LR134390_8	8.1\|1843679\|27\|LR134390\|PILER-CR	1843679-1843705	27	AP019525	Tenacibaculum phage PTm5 DNA, complete genome	21491-21517	5	0.815
LR134390_8	8.1\|1843679\|27\|LR134390\|PILER-CR	1843679-1843705	27	AP019524	Tenacibaculum phage PTm1 DNA, complete genome	21520-21546	5	0.815
LR134390_8	8.1\|1843679\|27\|LR134390\|PILER-CR	1843679-1843705	27	AP014047	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C12-MedDCM-OCT-S39-C144, * SEQUENCING IN PROGRESS *	9285-9311	5	0.815
LR134390_8	8.1\|1843679\|27\|LR134390\|PILER-CR	1843679-1843705	27	AP014050	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C12A-MedDCM-OCT-S36-C113, * SEQUENCING IN PROGRESS *	4443-4469	5	0.815
LR134390_8	8.1\|1843679\|27\|LR134390\|PILER-CR	1843679-1843705	27	AP014481	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C12-MedDCM-OCT-S44-C168, * SEQUENCING IN PROGRESS *, 3 ordered pieces	10947-10973	5	0.815
LR134390_8	8.1\|1843679\|27\|LR134390\|PILER-CR	1843679-1843705	27	AP014049	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C12A-MedDCM-OCT-S34-C33, * SEQUENCING IN PROGRESS *	21127-21153	5	0.815
LR134390_5	5.8\|1486749\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486749-1486783	35	CP020755	Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence	24919-24953	6	0.829
LR134390_5	5.8\|1486749\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486749-1486783	35	NZ_CP021062	Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence	240099-240133	6	0.829
LR134390_5	5.8\|1486749\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486749-1486783	35	NC_020385	Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-328, complete sequence	198954-198988	6	0.829
LR134390_5	5.9\|1486813\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486813-1486847	35	CP020755	Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence	24919-24953	6	0.829
LR134390_5	5.9\|1486813\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486813-1486847	35	NZ_CP021062	Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence	240099-240133	6	0.829
LR134390_5	5.9\|1486813\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486813-1486847	35	NC_020385	Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-328, complete sequence	198954-198988	6	0.829
LR134390_3	3.11\|1234015\|35\|LR134390\|CRT,CRISPRCasFinder,PILER-CR	1234015-1234049	35	KP027447	Staphylococcus phage phiIPLA-C1C, complete genome	107903-107937	7	0.8
LR134390_4	4.3\|1475799\|36\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1475799-1475834	36	NZ_CP033913	Chryseobacterium shandongense strain H5143 plasmid unnamed, complete sequence	65987-66022	7	0.806
LR134390_4	4.3\|1475799\|36\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1475799-1475834	36	NZ_CP033916	Chryseobacterium shandongense strain G0207 plasmid unnamed, complete sequence	7065-7100	7	0.806
LR134390_4	4.17\|1476706\|36\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1476706-1476741	36	NZ_LR215005	Mycoplasma conjunctivae strain NCTC10147 plasmid 9	128516-128551	7	0.806
LR134390_3	3.13\|1234144\|36\|LR134390\|CRT,CRISPRCasFinder,PILER-CR	1234144-1234179	36	NC_015715	Zymomonas mobilis subsp. pomaceae ATCC 29192 plasmid pZYMOP01, complete sequence	35028-35063	8	0.778
LR134390_4	4.8\|1476123\|35\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1476123-1476157	35	NZ_CP047429	Spiroplasma citri strain BLH-13 plasmid pSciBLH13-1, complete sequence	8192-8226	8	0.771
LR134390_4	4.8\|1476123\|35\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1476123-1476157	35	NZ_CP047434	Spiroplasma citri strain BLH-13 plasmid pSciBLH13-6	11783-11817	8	0.771
LR134390_4	4.8\|1476123\|35\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1476123-1476157	35	NZ_CP047434	Spiroplasma citri strain BLH-13 plasmid pSciBLH13-6	121421-121455	8	0.771
LR134390_4	4.8\|1476123\|35\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1476123-1476157	35	NZ_CP013198	Spiroplasma citri strain R8-A2 plasmid pSCI26, complete sequence	4895-4929	8	0.771
LR134390_4	4.8\|1476123\|35\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1476123-1476157	35	NZ_CP046373	Spiroplasma citri strain LB 319 plasmid pScpLB319-2, complete sequence	11563-11597	8	0.771
LR134390_4	4.8\|1476123\|35\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1476123-1476157	35	NZ_CP047438	Spiroplasma citri strain BLH-MB plasmid pSciBLHMB-1, complete sequence	45466-45500	8	0.771
LR134390_4	4.8\|1476123\|35\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1476123-1476157	35	NZ_CP047444	Spiroplasma citri strain BLH-MB plasmid pSciBLHMB-7	46829-46863	8	0.771
LR134390_4	4.3\|1475799\|36\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1475799-1475834	36	LN835295	Clostridium perfringens plasmid pJIR4150, complete sequence, strain JIR12708	18133-18168	9	0.75
LR134390_3	3.1\|1233372\|34\|LR134390\|CRT	1233372-1233405	34	MN693020	Marine virus AFVG_117M64, complete genome	3760-3793	10	0.706
LR134390_3	3.1\|1233372\|34\|LR134390\|CRT	1233372-1233405	34	MN693056	Marine virus AFVG_25M10, complete genome	56004-56037	10	0.706
LR134390_4	4.12\|1476380\|36\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1476380-1476415	36	NZ_CP012423	Spiroplasma kunkelii CR2-3x plasmid pSKU226, complete sequence	10729-10764	10	0.722
LR134390_5	5.8\|1486749\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486749-1486783	35	CP041516	Bacillus aryabhattai strain KNU10 plasmid unnamed, complete sequence	43118-43152	10	0.714
LR134390_5	5.8\|1486749\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486749-1486783	35	NZ_CP041068	Bacillus megaterium strain KNU-01 plasmid pKNU_01_4, complete sequence	10968-11002	10	0.714
LR134390_5	5.9\|1486813\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486813-1486847	35	CP041516	Bacillus aryabhattai strain KNU10 plasmid unnamed, complete sequence	43118-43152	10	0.714
LR134390_5	5.9\|1486813\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486813-1486847	35	NZ_CP041068	Bacillus megaterium strain KNU-01 plasmid pKNU_01_4, complete sequence	10968-11002	10	0.714
LR134390_3	3.1\|1233372\|34\|LR134390\|CRT	1233372-1233405	34	MN693220	Marine virus AFVG_25M60, complete genome	54656-54689	11	0.676
LR134390_3	3.11\|1234015\|35\|LR134390\|CRT,CRISPRCasFinder,PILER-CR	1234015-1234049	35	MK504446	Lactobacillus phage SAC12B, complete genome	47064-47098	11	0.686
LR134390_4	4.8\|1476123\|35\|LR134390\|PILER-CR,CRISPRCasFinder,CRT	1476123-1476157	35	NZ_CP013615	Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence	400146-400180	11	0.686
LR134390_5	5.8\|1486749\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486749-1486783	35	NC_025146	Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111	216591-216625	11	0.686
LR134390_5	5.8\|1486749\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486749-1486783	35	MN693596	Marine virus AFVG_25M324, complete genome	13769-13803	11	0.686
LR134390_5	5.8\|1486749\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486749-1486783	35	MK893987	Staphylococcus phage PMBT8, complete genome	61416-61450	11	0.686
LR134390_5	5.9\|1486813\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486813-1486847	35	NC_025146	Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111	216591-216625	11	0.686
LR134390_5	5.9\|1486813\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486813-1486847	35	MN693596	Marine virus AFVG_25M324, complete genome	13769-13803	11	0.686
LR134390_5	5.9\|1486813\|35\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486813-1486847	35	MK893987	Staphylococcus phage PMBT8, complete genome	61416-61450	11	0.686
LR134390_5	5.11\|1486942\|37\|LR134390\|CRT,PILER-CR,CRISPRCasFinder	1486942-1486978	37	NZ_CP010354	Acinetobacter johnsonii XBB1 plasmid pXBB1-3, complete sequence	5945-5981	12	0.676

1. spacer 8.1|1843679|27|LR134390|PILER-CR matches to MN694200 (Marine virus AFVG_250M858, complete genome) position: , mismatch: 4, identity: 0.852

agtaccagtaccacttattgttccttt	CRISPR spacer
aacaccagtaccacttattgtgccatt	Protospacer
*..****************** ** **

2. spacer 8.1|1843679|27|LR134390|PILER-CR matches to MN693492 (Marine virus AFVG_25M361, complete genome) position: , mismatch: 5, identity: 0.815

agtaccagtaccacttattgttccttt	CRISPR spacer
accaccagtaccacttgttgttccatc	Protospacer
* .*************.******* *.

3. spacer 8.1|1843679|27|LR134390|PILER-CR matches to AP014044 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C12-MedDCM-OCT-S24-C146, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 5, identity: 0.815

agtaccagtaccacttattgttccttt	CRISPR spacer
agtgccagtaccatttattgttcttaa	Protospacer
***.*********.*********.*

4. spacer 8.1|1843679|27|LR134390|PILER-CR matches to AP019525 (Tenacibaculum phage PTm5 DNA, complete genome) position: , mismatch: 5, identity: 0.815

agtaccagtaccacttattgttccttt	CRISPR spacer
aataccagtaccactaactgttcctgc	Protospacer
*.************* *.******* .

5. spacer 8.1|1843679|27|LR134390|PILER-CR matches to AP019524 (Tenacibaculum phage PTm1 DNA, complete genome) position: , mismatch: 5, identity: 0.815

agtaccagtaccacttattgttccttt	CRISPR spacer
aataccagtaccactaactgttcctgc	Protospacer
*.************* *.******* .

6. spacer 8.1|1843679|27|LR134390|PILER-CR matches to AP014047 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C12-MedDCM-OCT-S39-C144, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 5, identity: 0.815

agtaccagtaccacttattgttccttt	CRISPR spacer
agtgccagtaccatttattgttcttaa	Protospacer
***.*********.*********.*

7. spacer 8.1|1843679|27|LR134390|PILER-CR matches to AP014050 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C12A-MedDCM-OCT-S36-C113, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 5, identity: 0.815

agtaccagtaccacttattgttccttt	CRISPR spacer
agtaccagtaccatttatagttcgtaa	Protospacer
*************.**** **** *

8. spacer 8.1|1843679|27|LR134390|PILER-CR matches to AP014481 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C12-MedDCM-OCT-S44-C168, *** SEQUENCING IN PROGRESS ***, 3 ordered pieces) position: , mismatch: 5, identity: 0.815

agtaccagtaccacttattgttccttt	CRISPR spacer
agtaccagtaccatttatagttcgtaa	Protospacer
*************.**** **** *

9. spacer 8.1|1843679|27|LR134390|PILER-CR matches to AP014049 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C12A-MedDCM-OCT-S34-C33, *** SEQUENCING IN PROGRESS ***) position: , mismatch: 5, identity: 0.815

agtaccagtaccacttattgttccttt	CRISPR spacer
agtaccagtaccatttatagttcgtaa	Protospacer
*************.**** **** *

10. spacer 5.8|1486749|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to CP020755 (Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence) position: , mismatch: 6, identity: 0.829

agaaaca-attcatctattttttcacttttattaga	CRISPR spacer
-gatatacattcatctattttttcattttaattagc	Protospacer
 ** *.* *****************.*** *****

11. spacer 5.8|1486749|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP021062 (Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence) position: , mismatch: 6, identity: 0.829

agaaaca-attcatctattttttcacttttattaga	CRISPR spacer
-gatatacattcatctattttttcattttaattagc	Protospacer
 ** *.* *****************.*** *****

12. spacer 5.8|1486749|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to NC_020385 (Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-328, complete sequence) position: , mismatch: 6, identity: 0.829

agaaaca-attcatctattttttcacttttattaga	CRISPR spacer
-gatatacattcatctattttttcattttaattagc	Protospacer
 ** *.* *****************.*** *****

13. spacer 5.9|1486813|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to CP020755 (Bacillus thuringiensis strain ATCC 10792 plasmid pLDW-16, complete sequence) position: , mismatch: 6, identity: 0.829

agaaaca-attcatctattttttcacttttattaga	CRISPR spacer
-gatatacattcatctattttttcattttaattagc	Protospacer
 ** *.* *****************.*** *****

14. spacer 5.9|1486813|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP021062 (Bacillus thuringiensis strain ATCC 10792 plasmid poh1, complete sequence) position: , mismatch: 6, identity: 0.829

agaaaca-attcatctattttttcacttttattaga	CRISPR spacer
-gatatacattcatctattttttcattttaattagc	Protospacer
 ** *.* *****************.*** *****

15. spacer 5.9|1486813|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to NC_020385 (Bacillus thuringiensis serovar thuringiensis str. IS5056 plasmid pIS56-328, complete sequence) position: , mismatch: 6, identity: 0.829

agaaaca-attcatctattttttcacttttattaga	CRISPR spacer
-gatatacattcatctattttttcattttaattagc	Protospacer
 ** *.* *****************.*** *****

16. spacer 3.11|1234015|35|LR134390|CRT,CRISPRCasFinder,PILER-CR matches to KP027447 (Staphylococcus phage phiIPLA-C1C, complete genome) position: , mismatch: 7, identity: 0.8

attggtcaagaaaagagatactgaattaacttata	CRISPR spacer
ataagaaaagaaaagagaaacttaattaacttatt	Protospacer
** .*  *********** *** ***********

17. spacer 4.3|1475799|36|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033913 (Chryseobacterium shandongense strain H5143 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.806

aatttgaaaaatgaagttagaaaaaataatactttt-	CRISPR spacer
tttttgaaaactgtagttagaaaaaat-atgctttaa	Protospacer
  ******** ** ************* **.****

18. spacer 4.3|1475799|36|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP033916 (Chryseobacterium shandongense strain G0207 plasmid unnamed, complete sequence) position: , mismatch: 7, identity: 0.806

aatttgaaaaatgaagttagaaaaaataatactttt-	CRISPR spacer
tttttgaaaactgtagttagaaaaaat-atgctttaa	Protospacer
  ******** ** ************* **.****

19. spacer 4.17|1476706|36|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR215005 (Mycoplasma conjunctivae strain NCTC10147 plasmid 9) position: , mismatch: 7, identity: 0.806

ctaattgagtttctttaatttttactttaaatttca	CRISPR spacer
ctaattgagtttctttaatgtttaatttactcttgt	Protospacer
******************* **** ****  .**

20. spacer 3.13|1234144|36|LR134390|CRT,CRISPRCasFinder,PILER-CR matches to NC_015715 (Zymomonas mobilis subsp. pomaceae ATCC 29192 plasmid pZYMOP01, complete sequence) position: , mismatch: 8, identity: 0.778

agcagtgttagattcaattttagaatttcttttaat	CRISPR spacer
aattcttttagattcaatttttgaattttttttaaa	Protospacer
*..  * ************** ******.******

21. spacer 4.8|1476123|35|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP047429 (Spiroplasma citri strain BLH-13 plasmid pSciBLH13-1, complete sequence) position: , mismatch: 8, identity: 0.771

aaattaattgcatttttaaagttaagggggtaaaa---	CRISPR spacer
aaattaatttcatttttaaaattaa---agcaaatttg	Protospacer
********* **********.****   .*.***

22. spacer 4.8|1476123|35|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP047434 (Spiroplasma citri strain BLH-13 plasmid pSciBLH13-6) position: , mismatch: 8, identity: 0.771

aaattaattgcatttttaaagttaagggggtaaaa---	CRISPR spacer
aaattaatttcatttttaaaattaa---agcaaatttg	Protospacer
********* **********.****   .*.***

23. spacer 4.8|1476123|35|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP047434 (Spiroplasma citri strain BLH-13 plasmid pSciBLH13-6) position: , mismatch: 8, identity: 0.771

aaattaattgcatttttaaagttaagggggtaaaa---	CRISPR spacer
aaattaatttcatttttaaaattaa---agcaaatttg	Protospacer
********* **********.****   .*.***

24. spacer 4.8|1476123|35|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013198 (Spiroplasma citri strain R8-A2 plasmid pSCI26, complete sequence) position: , mismatch: 8, identity: 0.771

aaattaattgcatttttaaagttaagggggtaaaa---	CRISPR spacer
aaattaatttcatttttaaaattaa---agcaaatttg	Protospacer
********* **********.****   .*.***

25. spacer 4.8|1476123|35|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP046373 (Spiroplasma citri strain LB 319 plasmid pScpLB319-2, complete sequence) position: , mismatch: 8, identity: 0.771

aaattaattgcatttttaaagttaagggggtaaaa---	CRISPR spacer
aaattaatttcatttttaaaattaa---agcaaatttg	Protospacer
********* **********.****   .*.***

26. spacer 4.8|1476123|35|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP047438 (Spiroplasma citri strain BLH-MB plasmid pSciBLHMB-1, complete sequence) position: , mismatch: 8, identity: 0.771

aaattaattgcatttttaaagttaagggggtaaaa---	CRISPR spacer
aaattaatttcatttttaaaattaa---agcaaatttg	Protospacer
********* **********.****   .*.***

27. spacer 4.8|1476123|35|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP047444 (Spiroplasma citri strain BLH-MB plasmid pSciBLHMB-7) position: , mismatch: 8, identity: 0.771

aaattaattgcatttttaaagttaagggggtaaaa---	CRISPR spacer
aaattaatttcatttttaaaattaa---agcaaatttg	Protospacer
********* **********.****   .*.***

28. spacer 4.3|1475799|36|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to LN835295 (Clostridium perfringens plasmid pJIR4150, complete sequence, strain JIR12708) position: , mismatch: 9, identity: 0.75

---aatttgaaaaatgaagttagaaaaaataatactttt	CRISPR spacer
tcaaat---gaaaataaagttataaaaaataatactgaa	Protospacer
   ***   .*****.****** *************

29. spacer 3.1|1233372|34|LR134390|CRT matches to MN693020 (Marine virus AFVG_117M64, complete genome) position: , mismatch: 10, identity: 0.706

cttactgctgagaaagaatttgatggaaaagtat	CRISPR spacer
tgggctactgagaaagaatttgatagaatgaaat	Protospacer
.  .**.*****************.*** .. **

30. spacer 3.1|1233372|34|LR134390|CRT matches to MN693056 (Marine virus AFVG_25M10, complete genome) position: , mismatch: 10, identity: 0.706

cttactgctgagaaagaatttgatggaaaagtat	CRISPR spacer
tgggctactgagaaagaatttgatagaatgaaat	Protospacer
.  .**.*****************.*** .. **

31. spacer 4.12|1476380|36|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP012423 (Spiroplasma kunkelii CR2-3x plasmid pSKU226, complete sequence) position: , mismatch: 10, identity: 0.722

tctgttcttttttttcttagctttatttctcctttt	CRISPR spacer
actaaatagttttttcatatctttatttctcctttg	Protospacer
 **.  .  ******* ** ***************

32. spacer 5.8|1486749|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to CP041516 (Bacillus aryabhattai strain KNU10 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.714

agaaacaattcatctattttttcacttttattaga	CRISPR spacer
ttttctaaaccatctactttttcacttttatgaga	Protospacer
     .** .******.************** ***

33. spacer 5.8|1486749|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP041068 (Bacillus megaterium strain KNU-01 plasmid pKNU_01_4, complete sequence) position: , mismatch: 10, identity: 0.714

agaaacaattcatctattttttcacttttattaga	CRISPR spacer
ttttctaaaccatctactttttcacttttatgaga	Protospacer
     .** .******.************** ***

34. spacer 5.9|1486813|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to CP041516 (Bacillus aryabhattai strain KNU10 plasmid unnamed, complete sequence) position: , mismatch: 10, identity: 0.714

agaaacaattcatctattttttcacttttattaga	CRISPR spacer
ttttctaaaccatctactttttcacttttatgaga	Protospacer
     .** .******.************** ***

35. spacer 5.9|1486813|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP041068 (Bacillus megaterium strain KNU-01 plasmid pKNU_01_4, complete sequence) position: , mismatch: 10, identity: 0.714

agaaacaattcatctattttttcacttttattaga	CRISPR spacer
ttttctaaaccatctactttttcacttttatgaga	Protospacer
     .** .******.************** ***

36. spacer 3.1|1233372|34|LR134390|CRT matches to MN693220 (Marine virus AFVG_25M60, complete genome) position: , mismatch: 11, identity: 0.676

cttactgctgagaaagaatttgatggaaaagtat	CRISPR spacer
tgggctactgagaaagaatttgatagaatgaaac	Protospacer
.  .**.*****************.*** .. *.

37. spacer 3.11|1234015|35|LR134390|CRT,CRISPRCasFinder,PILER-CR matches to MK504446 (Lactobacillus phage SAC12B, complete genome) position: , mismatch: 11, identity: 0.686

attggtcaagaaaagagatactgaattaacttata	CRISPR spacer
gaataaagagaaaacagatgctgaattaacttatg	Protospacer
.   .  .****** ****.**************.

38. spacer 4.8|1476123|35|LR134390|PILER-CR,CRISPRCasFinder,CRT matches to NZ_CP013615 (Clostridium perfringens strain JP838 plasmid pJFP838A, complete sequence) position: , mismatch: 11, identity: 0.686

aaattaattgcatttttaaagttaagggggtaaaa	CRISPR spacer
aatttaattgcatttttaaaattaatttttattat	Protospacer
** *****************.****        *

39. spacer 5.8|1486749|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to NC_025146 (Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111) position: , mismatch: 11, identity: 0.686

agaaacaattcatctattttttcacttttattaga	CRISPR spacer
gtttctttttcatctagtttttcacttttcttata	Protospacer
.    .  ******** ************ *** *

40. spacer 5.8|1486749|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to MN693596 (Marine virus AFVG_25M324, complete genome) position: , mismatch: 11, identity: 0.686

agaaacaattcatctattttttcacttttattaga--	CRISPR spacer
ttaaaccattcatctatttttt--ctcttggcggtct	Protospacer
  **** ***************  **.**. ..*

41. spacer 5.8|1486749|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to MK893987 (Staphylococcus phage PMBT8, complete genome) position: , mismatch: 11, identity: 0.686

agaaacaattcatctattttttcacttttattaga	CRISPR spacer
aattttcgtttatctattttttcatttttattatt	Protospacer
*.   . .**.*************.********

42. spacer 5.9|1486813|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to NC_025146 (Clostridium botulinum plasmid pCB111 DNA, complete sequence, strain: 111) position: , mismatch: 11, identity: 0.686

agaaacaattcatctattttttcacttttattaga	CRISPR spacer
gtttctttttcatctagtttttcacttttcttata	Protospacer
.    .  ******** ************ *** *

43. spacer 5.9|1486813|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to MN693596 (Marine virus AFVG_25M324, complete genome) position: , mismatch: 11, identity: 0.686

agaaacaattcatctattttttcacttttattaga--	CRISPR spacer
ttaaaccattcatctatttttt--ctcttggcggtct	Protospacer
  **** ***************  **.**. ..*

44. spacer 5.9|1486813|35|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to MK893987 (Staphylococcus phage PMBT8, complete genome) position: , mismatch: 11, identity: 0.686

agaaacaattcatctattttttcacttttattaga	CRISPR spacer
aattttcgtttatctattttttcatttttattatt	Protospacer
*.   . .**.*************.********

45. spacer 5.11|1486942|37|LR134390|CRT,PILER-CR,CRISPRCasFinder matches to NZ_CP010354 (Acinetobacter johnsonii XBB1 plasmid pXBB1-3, complete sequence) position: , mismatch: 12, identity: 0.676

aggaaaacaacaagagcttttaaaagaagctttttta	CRISPR spacer
gttgaaacaacaaaaacttttaaaagaagccaaagca	Protospacer
.  .*********.*.**************.    .*

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

43901 : 79723

Clostridium_phage(45.16%)

tail,portal

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VEH37667.1\|43901_44336_-	Helix-turn-helix domain	A0A0S2SXM8	Bacillus_phage	4.6e-08	31.1
VEH37668.1\|44480_44693_+	Helix-turn-helix domain	A0A1W6JNS4	Staphylococcus_phage	1.3e-05	40.0
VEH37669.1\|44743_44968_+	Uncharacterised protein	NA	NA	NA	NA
VEH37670.1\|44957_45161_+	Uncharacterised protein	NA	NA	NA	NA
VEH37671.1\|45157_45508_+	Uncharacterised protein	NA	NA	NA	NA
VEH37672.1\|45523_45748_+	Uncharacterised protein	NA	NA	NA	NA
VEH37673.1\|45747_46065_+	Uncharacterised protein	NA	NA	NA	NA
VEH37674.1\|46387_46531_+	Uncharacterised protein	NA	NA	NA	NA
VEH37675.1\|46592_46784_+	Uncharacterised protein	NA	NA	NA	NA
VEH37676.1\|46794_46959_+	Uncharacterised protein	NA	NA	NA	NA
VEH37677.1\|46971_47202_+	Uncharacterised protein	A0A0S2MV91	Bacillus_phage	1.3e-06	62.5
VEH37678.1\|47259_47439_+	Uncharacterised protein	NA	NA	NA	NA
VEH37679.1\|47439_47697_+	Uncharacterised protein	NA	NA	NA	NA
VEH37680.1\|47709_48111_+	Uncharacterised protein	NA	NA	NA	NA
VEH37681.1\|48110_49268_+	Protein of uncharacterised function (DUF2800)	A0A0A7S066	Clostridium_phage	3.9e-99	48.7
VEH37682.1\|49268_49847_+	Protein of uncharacterised function (DUF2815)	W8CPL2	Croceibacter_phage	6.2e-37	45.8
VEH37683.1\|50027_52001_+	DNA polymerase I, thermostable	H7BVQ1	unidentified_phage	2.4e-221	58.4
VEH37684.1\|52064_52283_+	Uncharacterised protein	A0A0A7RWV6	Clostridium_phage	2.5e-15	52.8
VEH37685.1\|52300_54694_+	Predicted P-loop ATPase and inactivated derivatives	A0A0A7RTG3	Clostridium_phage	6.5e-205	46.5
VEH37686.1\|55046_55340_+	VRR-NUC domain	Q3LZN4	Bacteriophage	8.0e-17	56.2
VEH37687.1\|55355_56729_+	SNF2 family N-terminal domain	S5MA26	Brevibacillus_phage	1.1e-145	55.4
VEH37688.1\|56731_57415_+	DNA polymerase III subunit beta	NA	NA	NA	NA
VEH37689.1\|57430_57856_+	Uncharacterised protein	NA	NA	NA	NA
VEH37690.1\|58000_58810_+	V8-like Glu-specific endopeptidase	A0A2H4JE36	uncultured_Caudovirales_phage	7.4e-36	38.4
VEH37691.1\|58876_59398_+	Terminase small subunit	A0A0A0RSW5	Bacillus_phage	1.8e-19	34.2
VEH37692.1\|59384_60791_+	phage uncharacterized protein, C-terminal domain	A0A090EUA8	Clostridium_phage	1.1e-193	73.5
VEH37693.1\|60809_62243_+\|portal	phage portal protein, SPP1 family	A0A0A7S074	Clostridium_phage	1.4e-82	38.8
VEH37694.1\|62226_63960_+	NAD(+)--arginine ADP-ribosyltransferase EFV	A0A0A8WIE7	Clostridium_phage	3.3e-110	56.4
VEH37695.1\|63956_64142_+	Uncharacterised protein	NA	NA	NA	NA
VEH37696.1\|64197_64461_+	Uncharacterised protein	A0A0S2MYE7	Enterococcus_phage	1.4e-28	66.7
VEH37697.1\|64480_64597_+	Uncharacterised protein	NA	NA	NA	NA
VEH37698.1\|64727_65321_+	Phage minor structural protein GP20	Q5YA71	Bacillus_phage	4.9e-05	47.9
VEH37699.1\|65334_66288_+	Uncharacterised protein	A0A1J0MCK3	Streptomyces_phage	2.6e-80	52.4
VEH37700.1\|66301_66670_+	Uncharacterised protein	NA	NA	NA	NA
VEH37701.1\|66679_67081_+	Uncharacterised protein	NA	NA	NA	NA
VEH37702.1\|67077_67461_+	Uncharacterised protein	A0A0A7RTV0	Clostridium_phage	1.2e-15	41.5
VEH37703.1\|67460_67979_+	Uncharacterised protein	A0A0A7RTT0	Clostridium_phage	1.7e-22	36.8
VEH37704.1\|68004_68445_+	Uncharacterised protein	NA	NA	NA	NA
VEH37705.1\|68457_68643_+	Uncharacterised protein	NA	NA	NA	NA
VEH37706.1\|68643_69957_+\|tail	Phage tail sheath protein	X5JAJ1	Clostridium_phage	1.7e-130	52.2
VEH37707.1\|69974_70451_+	Phage-like element PBSX protein xkdM	A0A0A8WJ62	Clostridium_phage	2.1e-43	56.5
VEH37708.1\|70463_70874_+	Phage XkdN-like protein	Q708L8	Streptococcus_phage	1.3e-09	35.2
VEH37709.1\|71071_71581_+	Uncharacterised protein	NA	NA	NA	NA
VEH37710.1\|71571_73191_+\|tail	Phage-related minor tail protein	H7BVH2	unidentified_phage	3.2e-46	29.7
VEH37711.1\|73193_73850_+	LysM domain/BON superfamily protein	A0A0A8WFE5	Clostridium_phage	3.1e-32	40.7
VEH37712.1\|73842_74187_+	Uncharacterised protein	A0A0A7RTN6	Clostridium_phage	4.7e-08	37.3
VEH37713.1\|74180_74828_+	Uncharacterised protein	H7BVH4	unidentified_phage	1.5e-52	49.8
VEH37714.1\|74820_75261_+	Protein of uncharacterised function (DUF2577)	S5MC71	Brevibacillus_phage	5.1e-07	31.1
VEH37715.1\|75257_75683_+	Protein of uncharacterised function (DUF2634)	A0A0A8WFW6	Clostridium_phage	1.5e-24	49.2
VEH37716.1\|75675_76755_+	Uncharacterized homolog of phage Mu protein gp47	X5JAB8	Clostridium_phage	3.6e-78	46.1
VEH37717.1\|76741_77383_+	Uncharacterized protein conserved in bacteria (DUF2313)	NA	NA	NA	NA
VEH37718.1\|77372_78116_+	Uncharacterised protein	NA	NA	NA	NA
VEH37719.1\|78372_78630_-	Uncharacterised protein	NA	NA	NA	NA
VEH37720.1\|78763_79723_+	Tyrosine recombinase XerC	A0A0E3U2P3	Fusobacterium_phage	1.2e-74	45.3

DBSCAN-SWA_2

146498 : 154261

Staphylococcus_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VEH37788.1\|146498_146993_-	Glycyl-glycine endopeptidase ALE-1 precursor	I2E8W3	Clostridium_phage	5.9e-20	54.3
VEH37789.1\|147085_147331_-	Uncharacterised protein	NA	NA	NA	NA
VEH37790.1\|147485_148679_-	Multidrug export protein mepA	NA	NA	NA	NA
VEH37791.1\|148999_149524_+	6,7-dimethyl-8-ribityllumazine synthase	A0A2H4PQS3	Staphylococcus_phage	9.9e-42	55.7
VEH37792.1\|149526_150603_+	Riboflavin biosynthesis protein RibD	A0A2H4PQS8	Staphylococcus_phage	4.1e-50	34.7
VEH37793.1\|150611_151235_+	Riboflavin synthase alpha chain	A0A2H4PQS5	Staphylococcus_phage	2.5e-31	37.6
VEH37794.1\|151284_152478_+	Riboflavin biosynthesis protein ribBA	A0A2H4PQS2	Staphylococcus_phage	6.2e-116	54.2
VEH37795.1\|152592_153534_+	Ribosomal large subunit pseudouridine synthase D	A0A2H4UV25	Bodo_saltans_virus	8.6e-12	33.1
VEH37796.1\|153547_154261_+	Ribonuclease HII	E3T5H8	Cafeteria_roenbergensis_virus	7.4e-32	45.7

DBSCAN-SWA_3

628131 : 634237

Enterobacteria_phage(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VEH38294.1\|628131_629163_+	bifunctional fucokinase/L-fucose-1-P-guanylyltransferase	A0A222YW25	Synechococcus_phage	1.4e-68	43.2
VEH38295.1\|629372_629837_+	Phosphoheptose isomerase	A0A067XQR2	Caulobacter_phage	1.1e-07	35.1
VEH38296.1\|629840_630521_+	Glucose-1-phosphate cytidylyltransferase	A0A167R6F2	Powai_lake_megavirus	5.8e-10	25.4
VEH38297.1\|630619_631027_+	Uncharacterised protein	NA	NA	NA	NA
VEH38298.1\|631082_631652_+	Uncharacterised protein	NA	NA	NA	NA
VEH38299.1\|631676_632642_+	Uncharacterised protein	A0A1V0SDW6	Indivirus	5.0e-23	29.8
VEH38300.1\|632747_633611_+	Glucose-1-phosphate thymidylyltransferase 2	I7I009	Enterobacteria_phage	1.7e-102	63.5
VEH38301.1\|633625_634237_+	dTDP-4-dehydrorhamnose 3,5-epimerase	I7HJC4	Enterobacteria_phage	4.4e-49	52.5

DBSCAN-SWA_4

1311794 : 1317552

Prochlorococcus_phage(57.14%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
VEH39010.1\|1311794_1312274_+	N5-carboxyaminoimidazole ribonucleotide mutase	A0A2P0VNU7	Tetraselmis_virus	9.7e-28	48.0
VEH39011.1\|1312334_1313051_+	Phosphoribosylaminoimidazole-succinocarboxamide synthase	E3SPA9	Prochlorococcus_phage	3.6e-42	44.1
VEH39012.1\|1313050_1314448_+	Amidophosphoribosyltransferase precursor	A0A1B1ISH6	uncultured_Mediterranean_phage	3.3e-60	35.0
VEH39013.1\|1314469_1315471_+	Phosphoribosylformylglycinamidine cyclo-ligase	A0A1D7SQF5	Cyanophage	1.9e-65	44.2
VEH39014.1\|1315458_1316034_+	Phosphoribosylglycinamide formyltransferase	E3SNR5	Prochlorococcus_phage	4.3e-22	39.1
VEH39015.1\|1316050_1316374_+	Bifunctional purine biosynthesis protein PurH	E3SNU8	Prochlorococcus_phage	2.8e-26	58.7
VEH39016.1\|1316430_1317552_+	Bifunctional purine biosynthesis protein PurH	Q58MG4	Prochlorococcus_phage	3.2e-69	48.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. LR134390

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection