CRISPRimmunity

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Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_004721	Bacillus cereus ATCC 14579 plasmid pBClin15, complete sequence	0 crisprs	NA	0	0	1	0
NC_004722	Bacillus cereus ATCC 14579, complete sequence	3 crisprs	cas3,csa3,Cas14u_CAS-V,WYL,DinG,c2c10_CAS-V-U3,RT,DEDDh	0	3	10	0

Results visualization

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CRISPR-Cas detection and classification

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

365 : 15179

Bacillus_phage(75.0%)

The bacterium proteins that are colored denote the protein is present at specific phage-related keywords (such as 'capsid', 'head', 'integrase', 'plate', 'tail', 'fiber', 'coat', 'transposase', 'portal', 'terminase', 'protease' or 'lysin' and 'tRNA')

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_113732243.1\|365_551_+	helix-turn-helix domain-containing protein	B6RT33	Bacillus_virus	8.7e-09	54.1
WP_000185743.1\|537_1035_+	hypothetical protein	Q5ILD0	Bacillus_phage	5.1e-72	86.5
WP_113732235.1\|1109_1325_+	cytoplasmic protein	B6RT35	Bacillus_virus	3.3e-12	54.3
WP_001284675.1\|1389_2091_+	hypothetical protein	B6RT36	Bacillus_virus	5.9e-74	63.5
WP_000039472.1\|2103_4293_+	type B DNA polymerase	B6RT37	Bacillus_virus	0.0e+00	79.2
WP_113732236.1\|4295_4496_+	LexA family transcriptional regulator	A0A161ISH4	Bacillus_phage	2.9e-26	89.2
WP_165450346.1\|4511_4661_+	hypothetical protein	K7X6R4	Bacillus_phage	3.3e-11	78.6
WP_164928354.1\|4779_5127_+	hypothetical protein	NA	NA	NA	NA
WP_164928355.1\|5114_5669_+	hypothetical protein	B6RT44	Bacillus_virus	1.3e-28	49.3
WP_000060307.1\|6020_6671_+	hypothetical protein	S5YPG1	Bacillus_phage	2.5e-95	75.4
WP_000398582.1\|6683_6824_+	hypothetical protein	Q5ILB8	Bacillus_phage	1.1e-11	78.3
WP_165450347.1\|6838_6976_+	hypothetical protein	Q5ILB6	Bacillus_phage	2.0e-10	74.4
WP_000852326.1\|6979_8047_+	hypothetical protein	A0A160LKS4	Bacillus_phage	3.1e-135	65.6
WP_000157490.1\|8087_8318_+	hypothetical protein	A0A160LLA6	Bacillus_phage	2.0e-10	47.8
WP_011109762.1\|8320_8494_+	hypothetical protein	NA	NA	NA	NA
WP_001057982.1\|8567_8990_+	hypothetical protein	A0A160LKQ5	Bacillus_phage	4.7e-26	66.4
WP_001082420.1\|9163_9310_+	hypothetical protein	Q5ILA8	Bacillus_phage	1.5e-11	72.9
WP_000801967.1\|9321_9600_+	hypothetical protein	NA	NA	NA	NA
WP_001290296.1\|9612_10206_+	hypothetical protein	A0A160LKP5	Bacillus_phage	8.6e-26	44.4
WP_011109763.1\|10209_10941_+	glucosaminidase domain-containing protein	A0A160LKR7	Bacillus_phage	7.0e-102	84.7
WP_011109764.1\|10888_11410_+	membrane protein	A0A160LKQ7	Bacillus_phage	2.2e-65	72.3
WP_000032648.1\|11422_12217_+	hypothetical protein	A0A161JRA8	Bacillus_phage	8.3e-08	32.0
WP_000450149.1\|12221_14183_+	hypothetical protein	NA	NA	NA	NA
WP_001207867.1\|14195_14483_+	hypothetical protein	NA	NA	NA	NA
WP_000215889.1\|14495_15179_+	glycoside hydrolase family 25 protein	A0A160LKP9	Bacillus_phage	8.9e-83	67.3

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

2. NC_004722

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CRISPR-Cas detection and classification

Crispr_ID: NC_004722_1

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_004722_1

3307703-3307791

Orphan

Consensus_repeat	Method
GGCCGGTCGCTCCCGCCTGCCCCGTT	CRISPRCasFinder

1 spacers

The CRISPR arrays of NC_004722_1

>merge|NC_004722|1|3307703-3307791|CRISPRCasFinder
GGCCGGTCGCTCCCGCCTGCCCCGTTACCCCTTGTGGACCTTGGATTCCTTGTGGACCTTGAGGACCCGTTGCTCCCGTCTGGCCGGTT

>NC_004722|1|1|3307703-3307791|CRISPRCasFinder
GGCCGGTCGCTCCCGCCTGCCCCGTT	ACCCCTTGTGGACCTTGGATTCCTTGTGGACCTTGAG
GACCCGTTGCTCCCGTCTGGCCGGTT

Protein	Signature genes	Signature genes Name	Protein_function
NC_004722.1\|WP_000355451.1\|3300562_3301402_+\|DUF2785-domain-containing-protein	unknown	unknown	gnl\|CDD\|371322
NC_004722.1\|WP_001024472.1\|3314924_3315839_-\|tetratricopeptide-repeat-protein	unknown	unknown	gnl\|CDD\|276809
NC_004722.1\|WP_000540457.1\|3301419_3301866_+\|NUDIX-hydrolase	unknown	unknown	gnl\|CDD\|240033
NC_004722.1\|WP_000402273.1\|3318167_3319496_-\|HlyC/CorC-family-transporter	unknown	unknown	gnl\|CDD\|224173
NC_004722.1\|WP_000834865.1\|3313690_3314884_+\|MFS-transporter	unknown	unknown	gnl\|CDD\|340887
NC_004722.1\|WP_000539732.1\|3305635_3305884_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	unknown	unknown	gnl\|CDD\|225170
NC_004722.1\|WP_001072930.1\|3313035_3313578_-\|CGNR-zinc-finger-domain-containing-protein	unknown	unknown	gnl\|CDD\|378696
NC_004722.1\|WP_000241785.1\|3303263_3304421_+\|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	unknown	unknown	gnl\|CDD\|237107
NC_004722.1\|WP_000945243.1\|3306832_3306976_+\|hypothetical-protein	unknown	unknown	unknown
NC_004722.1\|WP_000938438.1\|3316954_3317503_-\|DUF2179-domain-containing-protein	unknown	unknown	gnl\|CDD\|235234
NC_004722.1\|WP_000411484.1\|3304450_3305572_-\|AI-2E-family-transporter	unknown	unknown	gnl\|CDD\|223701
NC_004722.1\|WP_000613883.1\|3317701_3318115_-\|ATP-synthase-subunit-I	unknown	unknown	gnl\|CDD\|377159
NC_004722.1\|WP_001215813.1\|3309585_3312093_-\|collagen-like-protein	unknown	unknown	gnl\|CDD\|367362
NC_004722.1\|WP_000601230.1\|3306093_3306555_+\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|379326
NC_004722.1\|WP_000747681.1\|3316592_3316832_+\|DUF3923-family-protein	unknown	unknown	gnl\|CDD\|289806
NC_004722.1\|WP_001290900.1\|3301874_3302873_-\|tryptophan--tRNA-ligase	unknown	unknown	gnl\|CDD\|183592
NC_004722.1\|WP_000207417.1\|3299716_3300439_-\|GNAT-family-N-acetyltransferase	unknown	unknown	gnl\|CDD\|366181
NC_004722.1\|WP_002195686.1\|3312239_3312926_-\|class-I-SAM-dependent-methyltransferase	unknown	unknown	gnl\|CDD\|379312
NC_004722.1\|WP_011110255.1\|3298825_3299665_-\|hypothetical-protein	unknown	unknown	unknown
NC_004722.1\|WP_000728046.1\|3316138_3316516_+\|hypothetical-protein	unknown	unknown	unknown

Protein	Function_ID	Function_description	E-value
NC_004722.1\|WP_000355451.1\|3300562_3301402_+\|DUF2785-domain-containing-protein	gnl\|CDD\|371322	pfam10978, DUF2785, Protein of unknown function (DUF2785). Some members in this family are annotated as hypothetical membrane spanning proteins however this cannot be confirmed. The family has no known function.	1.69702e-39
NC_004722.1\|WP_001024472.1\|3314924_3315839_-\|tetratricopeptide-repeat-protein	gnl\|CDD\|276809	sd00006, TPR, Tetratricopeptide repeat. The Tetratricopeptide repeat (TPR) typically contains 34 amino acids and is found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans. It is present in a variety of proteins including those involved in chaperone, cell-cycle, transcription, and protein transport complexes. The number of TPR motifs varies among proteins. Those containing 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accommodate an alpha-helix of a target protein. It has been proposed that TPR proteins preferentially interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes.	3.42477e-14
NC_004722.1\|WP_000540457.1\|3301419_3301866_+\|NUDIX-hydrolase	gnl\|CDD\|240033	cd04677, Nudix_Hydrolase_18, Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & "house-cleaning" enzymes. Substrate specificity is used to define families within the superfamily. Differences in substrate specificity are determined by the N-terminal extension or by residues in variable loop regions. Mechanistically, substrate hydrolysis occurs by a nucleophilic substitution reaction, with variation in the numbers and roles of divalent cations required.	1.91073e-59
NC_004722.1\|WP_000834865.1\|3313690_3314884_+\|MFS-transporter	gnl\|CDD\|340887	cd17329, MFS_MdtH_MDR_like, Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily. This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	2.05059e-70
NC_004722.1\|WP_000539732.1\|3305635_3305884_-\|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein	gnl\|CDD\|225170	COG2261, COG2261, Predicted membrane protein [Function unknown].	1.19524e-08
NC_004722.1\|WP_001072930.1\|3313035_3313578_-\|CGNR-zinc-finger-domain-containing-protein	gnl\|CDD\|378696	pfam11706, zf-CGNR, CGNR zinc finger. This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	5.22761e-18
NC_004722.1\|WP_000241785.1\|3303263_3304421_+\|1-deoxy-D-xylulose-5-phosphate-reductoisomerase	gnl\|CDD\|237107	PRK12464, PRK12464, 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional.	0
NC_004722.1\|WP_000938438.1\|3316954_3317503_-\|DUF2179-domain-containing-protein	gnl\|CDD\|235234	PRK04164, PRK04164, hypothetical protein; Provisional.	6.88941e-83
NC_004722.1\|WP_000411484.1\|3304450_3305572_-\|AI-2E-family-transporter	gnl\|CDD\|223701	COG0628, yhhT, Predicted permease, member of the PurR regulon [General function prediction only].	2.99865e-58
NC_004722.1\|WP_000613883.1\|3317701_3318115_-\|ATP-synthase-subunit-I	gnl\|CDD\|377159	pfam03899, ATP-synt_I, ATP synthase I chain. The atp operon of alkaliphilic Bacillus pseudofirmus OF4, as in most prokaryotes, contains the eight structural genes for the F-ATPase (ATP synthase), which are preceded by an atpI gene that encodes a membrane protein with 2 TMSs. A tenth gene, atpZ, has been found in this operon, which is upstream of and overlapping with atpI. AtpI is a Ca2+/Mg2+ transporter.	2.84419e-07
NC_004722.1\|WP_001215813.1\|3309585_3312093_-\|collagen-like-protein	gnl\|CDD\|367362	pfam03157, Glutenin_hmw, High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.	1.59235e-08
NC_004722.1\|WP_000601230.1\|3306093_3306555_+\|GNAT-family-N-acetyltransferase	gnl\|CDD\|379326	pfam13673, Acetyltransf_10, Acetyltransferase (GNAT) domain. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	1.15708e-12
NC_004722.1\|WP_000747681.1\|3316592_3316832_+\|DUF3923-family-protein	gnl\|CDD\|289806	pfam13061, DUF3923, Protein of unknown function (DUF3923). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	4.67763e-12
NC_004722.1\|WP_001290900.1\|3301874_3302873_-\|tryptophan--tRNA-ligase	gnl\|CDD\|183592	PRK12556, PRK12556, tryptophanyl-tRNA synthetase; Provisional.	0
NC_004722.1\|WP_000207417.1\|3299716_3300439_-\|GNAT-family-N-acetyltransferase	gnl\|CDD\|366181	pfam00583, Acetyltransf_1, Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	3.45413e-06
NC_004722.1\|WP_002195686.1\|3312239_3312926_-\|class-I-SAM-dependent-methyltransferase	gnl\|CDD\|379312	pfam13649, Methyltransf_25, Methyltransferase domain. This family appears to be a methyltransferase domain.	7.07678e-23
NC_004722.1\|WP_000402273.1\|3318167_3319496_-\|HlyC/CorC-family-transporter	gnl\|CDD\|224173	COG1253, TlyC, Hemolysins and related proteins containing CBS domains [General function prediction only].	2.61301e-160

>NC_004722.1|WP_000945243.1|3306832_3306976_+|hypothetical-protein
MLRLSDHAIKMMEQRLRIEKQRTYQANKVVDNLHHKYFFQHIFQPKR
>NC_004722.1|WP_000601230.1|3306093_3306555_+|GNAT-family-N-acetyltransferase
MILKLNSTSFEVATSILQVQIPAYKVEADYLNSTAIPRLYDTVNDIQNCVETFYGYFSENKLVGFISFVQEEKLIDIHRLVVSPNFFQKGIATKLLIYIFNMFPSSMAYIVQTGKANTPAITLYKKHGFITVSDTILPDGMILTQLKKTEYTK
>NC_004722.1|WP_000539732.1|3305635_3305884_-|GlsB/YeaQ/YmgE-family-stress-response-membrane-protein
MGWIITLIVGAIIGAIASSITGKNFPGGMFGNIIAGLLGASLGGRLFGSFGPSFGGIHVVPALLGAIVLILIVSFVVKAAKK
>NC_004722.1|WP_000411484.1|3304450_3305572_-|AI-2E-family-transporter
MEKINIRKRDKLRKFFREQNYLAVLLGFALLFINILLLTKISFVFTPFIVFLKTIFFPVLLAGVLFYILHPFVSLLEKKGVSRIVSIASIYLIVLGLFVFLVVTVIPIIKDQIDALIDNLPYFGHEIEQAARRFGESNLLGKIQENLNINVANMVKEYTVDFTKSLSSVTGNVTGFLSTVTEVVLTFVMVPFILFYLLKDGEQLPNHFLKFISEQRQPAAMRILDDMHYAISSYIRGQIIVSLFIGIMLLIGYLIIGIKYAVLLAILAMIVNIVPYVGPIIAITPALIIAFIDSPAMVLKVIIVMMVVQLAEGKFISPQVMGKKLDIHPITIIFIILTAGNLFGIMGIILAIPGYAILKVLVTHGYRFVKLNT
>NC_004722.1|WP_000241785.1|3303263_3304421_+|1-deoxy-D-xylulose-5-phosphate-reductoisomerase
MVKYISILGSTGSIGTSALDVVSAHPEHFKIVGLTANYNIDLLEQQIKTFQPRIVSVATKDLADKLRTRISANTKITHGTDGFIAVATHPDSNLVLSSVVGVSGLLPTIEALKAKKDIAIANKETLVAAGHIVTELAKQNGCRLIPVDSEHSAIFQCLKGENNKEIEKLIVTASGGAFRDKTRDEMQTLQAKDALKHPNWLMGAKLTIDSATLMNKGFEVMEARWLFDIPYKKINVMIHKESIIHSLVEFIDGSVMAQLGAPDMRMPIQYAFHYPTRLPSSYEKLNLLEIGSLHFEKPDLEKFPCLQYAYECGKIGGTTPAVLNAANEIANALFLKNEIAFFDIEKTIYKTVEAHHNVKDPSLDAILEADQWARQYANELLIKKR
>NC_004722.1|WP_001290900.1|3301874_3302873_-|tryptophan--tRNA-ligase
MSEKIMLTGIKPTGYPHLGNYIGAIKPALQMSKNNEGRALYFIADYHALNAVHDSEKFSSYTKEVAATWLSLGLGEDVVFYRQTEVPEILELAWILACLTPKGLMNRAHAYKAKVEQNKEAGLEVDAGVNMGLYTYPILMAADILLFQATHVPVGKDQIQHIEIARDIATYFNHTFGTTFTLPEYVVQEEGAILPGLDGRKMSKSYGNVIPLFAEQEKLRKLIFKIKTDSSLPNEPKELETLFMIYKEFATEDEVQSLREKYETGIGWGDVKKELFRVVDHELAGPREKYAMYMNEPDLLYEALENGAEKARAIAKINLAEIKKRIGFERER
>NC_004722.1|WP_000540457.1|3301419_3301866_+|NUDIX-hydrolase
MGYIEDMRNLVGNHPLILIGSHAIILNEKDEVLLQLRTDFNRWGIIGGALEYNETLEDALKREVFEETGLIIKNPELFRTYSGPDFFQIYPNGDQVHGVLVVYICREFHGELVCDHTESKELRFFSLDELPNNLPPVIEKIITDYLKK
>NC_004722.1|WP_000355451.1|3300562_3301402_+|DUF2785-domain-containing-protein
MDITALQQQLELIQQNDYTQLQHIDVNELTLNMLQYIGTTDSYVRYQLIYKCFAHFIHHEFLMDDQLKLLLQTCLSDEYLYCDIYSPHTDGVFTRSYTVSLIALILQFANSHYFCTEEDIEEIKNKLITYTNLETDFRGYIENKGWAHCLAHVSDAFTEIVHNTYTTFEWYEELIHCLLNKIFIPSDLFHNNEDERIVTPLLAMLYHDFPQNDLISIIHKKIKRLPQIRKRLSLNEYCILCANIKTFLRTLFFRTKDDHNLAFTARKTERMLKELPNYY
>NC_004722.1|WP_000207417.1|3299716_3300439_-|GNAT-family-N-acetyltransferase
MTTIEQLEKHFKIRRSASSIMIKENNAEVFTEEQLEEMVQYYVAEAEKDGLEKLHFEISSKSPNYDVYKKCFETYSFEYVTENMIVFKDIYEVEDVESEIDFKLIEEVGEEAFYSLWNEATGEPVAHDQFVHMMLEEIGEQWKEHCLIASVGEEPIGIVIPYIERGALEEGKLMYFAVTPNMRNKGYEAALFAGAMFVLKEIGASYYIGETNMQNEWMKDVFEKNGCQLLSSTERYVRKF
>NC_004722.1|WP_011110255.1|3298825_3299665_-|hypothetical-protein
MLKQSMHSFVLLYPNVLLEGWNVEKVSERYEGEKWGTFWFQVVTPTGMFRVKEFFLDIMEPVFPDSCISQAKGDCFQYKGLVYWKGINYKGKESYVTSIWKTQVEISVDHGYVNQDEMERFLFELQPVNMELGKTILHTSFHLLSFQAKRSEMGEIGRCREWNAPDDVSYVNLLIHEKLNWKLESVGFGNDETQYVYWDEVNKLYALWVCRHKNKAYYPISSWTMNYGPKQIINGLEFYSHPNRGTVVYEDLGNEQIAYVFRGNPCTNFEQVKELFACL
>NC_004722.1|WP_001215813.1|3309585_3312093_-|collagen-like-protein
MRHHRKCKKFGVALPLPLIGTTGPTGNSGPIGPTGGHEGPVGPTGVTGPTGATGPQGPQGIRGIQGPRGTTGAQGIQGVIGDTGEQGITGPTGLQGAQGLIGNQGLIGDIGVQGLEGIQGATGPAGSQGIQGIQGIQGEIGERGQTGAQGMQGERGVTGVSGVTGPQGPQGVQGIKGEQGAIGIQGEDGFQGIQGITGEEGPQGAQGIQGEVGPTGSTGMQGAQGISGIKGITGAIGLQGPQGVQGIQGITGATGFQGIKGIRGITGATGSIGTQGSEGPPGGPTGVTGPIGPSSGVTGPAGPPGPPGGPTGPTGATGSTGVSGGIGPIGGQGVQGITGPTGHQGVRGAQGAQGVVGAVGVQGAQGPQGNQGITGPTGAEGSQGIQGPLGVTGPTGAEGPKGIQGIQGVIGPTGAQGMVGIQGIAGPVGVTGAEGAQGAQGIRGATGPAGAQGIQGVQGIQGETGAAGTQGPQGVQGIQGTTGLTGTQGAQGPQGVQGIIGPTGAIGLQGPQGLQGITGPTGAQGVQGIQGVQGIIGPTGAQGIRGPQGNTGEIGITGPQGVQGAQGSQGPQGPQGNVGITGATGETGATGATGATGPQGVQGVQGITGIQGITGTAGNTGATSSQGIQGIQGVQGLQGPTGASGVTGASGSIGPVGAQGSQGPSGVVGPTGATGSAGSIGFFGIAGATGATGLPSGGGYFFSTSTSTIAANALIPINSGSTVFGSDVSLTNATTVTLSTPGIYLVSYYFQGDPTAGNETISVRLTLNGTQVAGSFIFYVTGGTFILEPAVSNTMVIEVTFSNATLSLQNGPLAIGHVTTLSGVITASLNVLKIV
>NC_004722.1|WP_002195686.1|3312239_3312926_-|class-I-SAM-dependent-methyltransferase
MDCLPKYGPYTASEDEIHLFDSIKDKKVLDIGCGSGHSLQYMAEHGAEELWGLDFSRTQIETAHETLQSWNPKLICGAMEEEGDIPKGYFDIVYSIYALGWTSDLRKTLELIYSYVKPGGSFIFSWEHPVYSNLQYGTEEVAIKSSYHEETPITFETFKGENVQATLYKRKISTYINELNRVGFKIKRIEEPEPSSSFDGELAEPSMKYYSLYKARMVPTTFIIKARK
>NC_004722.1|WP_001072930.1|3313035_3313578_-|CGNR-zinc-finger-domain-containing-protein
MNQNAPNELEYIREFLNTWRIPNDTREPIDLLQTEEDIKLFMKEYFDEEFPFHTIEELRGFREDIRMTIEGEGSLQKWLEKYPFHVHIKDDMKGITYEPVYEENVYTKVLSIVLMSIQENVWGRLKACPDCRWVFYDHSRNGSKRWCGMYAGEEGGRACGTIAKVKNYRAKRKGRSGYDM
>NC_004722.1|WP_000834865.1|3313690_3314884_+|MFS-transporter
MKSFSTPIRFMLISSFFMSFGYFAVYAFLAIYLLTFLHFSAVQVGTVLTVMTITSRVIPLFSGLIADKIGYIIMMIAGLFLRGIGFIALGICSDFYTISISSALIGFGTAFYEPAARAIFGSQPAHLRKNLFTYLNLSFNCGAIIGPIAGGFILLLDPIYAFSLTGSLMLLFAFIFYLLKNHFQVTTENTSITLGIQAILQNKSFLLFSFIMIFFYIMFTQLTVALPLHMKNISSSNQLATLVITINAITGVIFMVLFRKLFHKYNTLSIIKYGVLLMSISFLLIPLFQHPYWLFICVILFTIGETLVLPNADITIANYSNESYTATFFGFYQLSLAFGFIIGNYTGTSSTSNLSGMYTPWLIFGGIGLIGFISLHILNIKKVASKEDIHLCNTSDL
>NC_004722.1|WP_001024472.1|3314924_3315839_-|tetratricopeptide-repeat-protein
MNINEKAIEMFEQNKYEEAMELFQQAVHKSRDVQSLNNLAWMYFYEEENDEKALELIREVVKLNPSSYFPYNILGEIYIKQKKWEEAKEVLQKSISIQPSDEAYHNVAVAHYNLGELEKASDFFLRVAGDSDYIMYSYVKCLIDLERTTEAKEKLDTFNRESDNFLGEINVADLYVELNCYKEAIEWFEKGYKECWKSPNWIGRFVYALYKTNNFSRINEVIRECIEAKTAEIEDVQNEEVEENWTENDKKELIEEYTEENNCYKTMVERIKSGYVPGLEFETDYIGACYLFGCKRHNHLEYEK
>NC_004722.1|WP_000728046.1|3316138_3316516_+|hypothetical-protein
MKKKLLVLLFTGIILSGCSTIAENSLESGKGSMELLTPTITAKDNELEIKTKGIDENKVTFIYVANKKVLEQKLKNGESYKLNIKDIEHAHRTDYKPKVQLLQTKDDDDDGEIVTFKQVRYTVKN
>NC_004722.1|WP_000747681.1|3316592_3316832_+|DUF3923-family-protein
MKKRWISWWIGNIFWIIVFGIWAAIIWLRDVDGAGVIQTPEIKSISLIVLLITFIIPVFFQIIWLIINLRMSKKHNYTI
>NC_004722.1|WP_000938438.1|3316954_3317503_-|DUF2179-domain-containing-protein
MLQALLIFVLQIIYVPILTIRTILLVKNQTRSAAGVGLLEGAIYIVSLGIVFQDLSNWMNIVAYVIGFSAGLLLGGYIENKLAIGYITYQVSLLDRCNELVDELRHSGFGVTVFEGEGINSIRYRLDIVAKRSREKELLEIINEIAPKAFMSSYEIRSFKGGYLTKAMKKRALMKKKDEHAS
>NC_004722.1|WP_000613883.1|3317701_3318115_-|ATP-synthase-subunit-I
MIQEALRVYRLQLYVIFSGLLLMWTITPFGKQVTGFGIGLAVSAYCLWLLARRVEKLGKSIVMKKKAPGLGVLNRFAAAILGAIIMYEIEHEMEMWAFGTGILGGHFLMIANLAYANMQLVKEEEKQREHASKNIEL
>NC_004722.1|WP_000402273.1|3318167_3319496_-|HlyC/CorC-family-transporter
MEIFNLVMVAILIAFTGFFVAAEFAIVKVRSSRIDQLVAEGKRGALAAKKVTTNLDEYLSACQLGITVTAMGLGWLGEPTIEKLLHPLFEKWNLNPSISSVLTFGLAFMLMTYLHVVVGELAPKTMAIQKAEKVTLLFAAPLMMFYKVMYPFIWVLNGSARVITGLFGLKPASEHEVAHTEEELRLILSDSYESGEINQAEYKYVNNIFEFDNRIAKEIMVPRTEIVGFYLEDSVEEHMKVIQNERYTRYPIFGEDKDDIIGMVNVKDFFIRYMTEDQKDLSSIRSYMRPIIEVMETTPIHDLLLQMQKKRIPMAVLYDEYGGTAGIVTLEDILEEIVGEIRDEYDEDEAPPIQHVNEQHIIVDGKVLISEVKDLFGLHIEEDDVDTIGGWIMMQNHEIEEGQHVEAEGFEFKVLEKDAYQIKRVEIRKMEQEQEEEKAATV

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Crispr_ID: NC_004722_2

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_004722_2

5193025-5193158

Orphan

Consensus_repeat	Method
GTTGATTTCTCTTCTTTTTGAGA	CRISPRCasFinder

2 spacers

The CRISPR arrays of NC_004722_2

>merge|NC_004722|2|5193025-5193158|CRISPRCasFinder
GTTGATTTTTCTTCTTTCTTCGGTTCTTCTTTTTTGTCACTAGTTGAACCGCTTGTTGATTTCTCTTCTTTTTGAGACTTGTCTTCTGTTTTACTTTCCGGTTTCGTGCTCGTTGACTTCTCTTCTTTTTGAGA

>NC_004722|2|2|5193025-5193158|CRISPRCasFinder
GTTGATTTTTCTTCTTTCTTCGG	TTCTTCTTTTTTGTCACTAGTTGAACCGCTT
GTTGATTTCTCTTCTTTTTGAGA	CTTGTCTTCTGTTTTACTTTCCGGTTTCGTGCTC
GTTGACTTCTCTTCTTTTTGAGA

Protein	Signature genes	Signature genes Name	Protein_function
NC_004722.1\|WP_001207193.1\|5187375_5188077_-\|CpsD/CapB-family-tyrosine-protein-kinase	unknown	unknown	gnl\|CDD\|349772
NC_004722.1\|WP_000008901.1\|5192702_5192837_-\|hypothetical-protein	unknown	unknown	unknown
NC_004722.1\|WP_000057889.1\|5200209_5200446_-\|DUF1146-domain-containing-protein	unknown	unknown	gnl\|CDD\|227173
NC_004722.1\|WP_000367459.1\|5200648_5202169_-\|NADH-quinone-oxidoreductase-subunit-NuoN	unknown	unknown	gnl\|CDD\|235603
NC_004722.1\|WP_000672662.1\|5196882_5197902_-\|stage-II-sporulation-protein-D	unknown	unknown	gnl\|CDD\|274332
NC_004722.1\|WP_033685340.1\|5183496_5185305_-\|polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|224011
NC_004722.1\|WP_000757832.1\|5185366_5186248_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	unknown	unknown	gnl\|CDD\|224131
NC_004722.1\|WP_000393128.1\|5188066_5188810_-\|capsular-polysaccharide-biosynthesis-protein	unknown	unknown	gnl\|CDD\|226453
NC_004722.1\|WP_011110492.1\|5186496_5187264_-\|tyrosine-protein-phosphatase	unknown	unknown	gnl\|CDD\|226870
NC_004722.1\|WP_000170865.1\|5194750_5195593_-\|ABC-transporter-ATP-binding-protein	unknown	unknown	gnl\|CDD\|224054
NC_004722.1\|WP_000931959.1\|5190095_5190530_-\|3-hydroxyacyl-ACP-dehydratase-FabZ	unknown	unknown	gnl\|CDD\|234568
NC_004722.1\|WP_000411274.1\|5198109_5199414_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	unknown	unknown	gnl\|CDD\|236486
NC_004722.1\|WP_002005985.1\|5199453_5200164_-\|YwmB-family-TATA-box-binding-protein	unknown	unknown	gnl\|CDD\|370056
NC_004722.1\|WP_000544012.1\|5192121_5192394_-\|sporulation-transcriptional-regulator-SpoIIID	unknown	unknown	gnl\|CDD\|378813
NC_004722.1\|WP_000568230.1\|5203669_5205532_-\|NADH-quinone-oxidoreductase-subunit-L	unknown	unknown	gnl\|CDD\|235836
NC_004722.1\|WP_000467955.1\|5189073_5189751_-\|CpsD/CapB-family-tyrosine-protein-kinase	unknown	unknown	gnl\|CDD\|349772
NC_004722.1\|WP_000457980.1\|5190959_5191961_-\|rod-shape-determining-protein	unknown	unknown	gnl\|CDD\|237563
NC_004722.1\|WP_000144450.1\|5194046_5194751_-\|ABC-transporter-permease	unknown	unknown	gnl\|CDD\|378925
NC_004722.1\|WP_001185912.1\|5195774_5196782_-\|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	unknown	unknown	gnl\|CDD\|224054
NC_004722.1\|WP_000998926.1\|5202170_5203673_-\|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl\|CDD\|235622

Protein	Function_ID	Function_description	E-value
NC_004722.1\|WP_001207193.1\|5187375_5188077_-\|CpsD/CapB-family-tyrosine-protein-kinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	4.59934e-83
NC_004722.1\|WP_000544012.1\|5192121_5192394_-\|sporulation-transcriptional-regulator-SpoIIID	gnl\|CDD\|378813	pfam12116, SpoIIID, Stage III sporulation protein D. This stage III sporulation protein is a small DNA-binding family that is essential for gene expression of the mother-cell compartment during sporulation. The domain is found in bacteria and viruses, and is about 40 amino acids in length. It has a conserved RGG sequence motif.	1.17272e-38
NC_004722.1\|WP_000057889.1\|5200209_5200446_-\|DUF1146-domain-containing-protein	gnl\|CDD\|227173	COG4836, COG4836, Predicted membrane protein [Function unknown].	1.23409e-23
NC_004722.1\|WP_000367459.1\|5200648_5202169_-\|NADH-quinone-oxidoreductase-subunit-NuoN	gnl\|CDD\|235603	PRK05777, PRK05777, NADH-quinone oxidoreductase subunit NuoN.	4.09428e-151
NC_004722.1\|WP_000672662.1\|5196882_5197902_-\|stage-II-sporulation-protein-D	gnl\|CDD\|274332	TIGR02870, Stage_II_sporulation_protein_D, stage II sporulation protein D. Stage II sporulation protein D (SpoIID) is a protein of the endospore formation program in a number of lineages in the Firmicutes (low-GC Gram-positive bacteria). It is expressed in the mother cell compartment, under control of Sigma-E. SpoIID, along with SpoIIM and SpoIIP, is one of three major proteins involved in engulfment of the forespore by the mother cell. [Cellular processes, Sporulation and germination].	4.7774e-134
NC_004722.1\|WP_033685340.1\|5183496_5185305_-\|polysaccharide-biosynthesis-protein	gnl\|CDD\|224011	COG1086, COG1086, Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism].	0
NC_004722.1\|WP_000757832.1\|5185366_5186248_-\|UTP--glucose-1-phosphate-uridylyltransferase-GalU	gnl\|CDD\|224131	COG1210, GalU, UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane].	0
NC_004722.1\|WP_000393128.1\|5188066_5188810_-\|capsular-polysaccharide-biosynthesis-protein	gnl\|CDD\|226453	COG3944, COG3944, Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane].	9.79397e-84
NC_004722.1\|WP_011110492.1\|5186496_5187264_-\|tyrosine-protein-phosphatase	gnl\|CDD\|226870	COG4464, CapC, Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane].	1.30108e-105
NC_004722.1\|WP_000931959.1\|5190095_5190530_-\|3-hydroxyacyl-ACP-dehydratase-FabZ	gnl\|CDD\|234568	PRK00006, fabZ, 3-hydroxyacyl-ACP dehydratase FabZ.	5.26499e-95
NC_004722.1\|WP_000411274.1\|5198109_5199414_-\|UDP-N-acetylglucosamine-1-carboxyvinyltransferase	gnl\|CDD\|236486	PRK09369, PRK09369, UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated.	0
NC_004722.1\|WP_002005985.1\|5199453_5200164_-\|YwmB-family-TATA-box-binding-protein	gnl\|CDD\|370056	pfam08680, DUF1779, TATA-box binding. TATA-box_bdg is a family of bacterial proteins. YwmB from Bacillus subtilis contains a circularly permuted TATA-box binding protein-like fold. Jian-Xiang Liu, Qi Xie, Jun Lin. Protein Structural Data Mining and Evolutionary Bioinformatic Analysis on Domains of TATA-box Binding Protein-like Fold. Life Science Journal 2014; 11(2): 298-302 (not yet in PubMed 27-02-2014).	5.16446e-34
NC_004722.1\|WP_000170865.1\|5194750_5195593_-\|ABC-transporter-ATP-binding-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	1.37567e-89
NC_004722.1\|WP_000568230.1\|5203669_5205532_-\|NADH-quinone-oxidoreductase-subunit-L	gnl\|CDD\|235836	PRK06590, PRK06590, NADH:ubiquinone oxidoreductase subunit L; Reviewed.	0
NC_004722.1\|WP_000467955.1\|5189073_5189751_-\|CpsD/CapB-family-tyrosine-protein-kinase	gnl\|CDD\|349772	cd05387, BY-kinase, bacterial tyrosine-kinase. Bacterial tyrosine (BY)-kinases catalyze the autophosphorylation on a C-terminal tyrosine cluster and also phosphorylate endogenous protein substrates by using ATP as phosphoryl donor. Besides their capacity to function as tyrosine kinase, most of these proteins are also involved in the production and transport of exopolysaccharides. BY-kinases are involved in a number of physiological processes ranging from stress resistance to pathogenicity.	4.05004e-82
NC_004722.1\|WP_000457980.1\|5190959_5191961_-\|rod-shape-determining-protein	gnl\|CDD\|237563	PRK13928, PRK13928, rod shape-determining protein Mbl; Provisional.	0
NC_004722.1\|WP_000144450.1\|5194046_5194751_-\|ABC-transporter-permease	gnl\|CDD\|378925	pfam12698, ABC2_membrane_3, ABC-2 family transporter protein. This family is related to the ABC-2 membrane transporter family pfam01061.	5.76202e-05
NC_004722.1\|WP_001185912.1\|5195774_5196782_-\|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein	gnl\|CDD\|224054	COG1131, CcmA, ABC-type multidrug transport system, ATPase component [Defense mechanisms].	6.6532e-32
NC_004722.1\|WP_000998926.1\|5202170_5203673_-\|NADH-quinone-oxidoreductase-subunit-M	gnl\|CDD\|235622	PRK05846, PRK05846, NADH:ubiquinone oxidoreductase subunit M; Reviewed.	2.00709e-177

>NC_004722.1|WP_000008901.1|5192702_5192837_-|hypothetical-protein
MSFLFVLSTAIILLFVLFTLYYYIAGKKEVPHHQLLEEEFEREE
>NC_004722.1|WP_000544012.1|5192121_5192394_-|sporulation-transcriptional-regulator-SpoIIID
MHDYIKERTIKIGKYIVETRKTVRVIAKEFGVSKSTVHKDLTERLPEINPELANEVKEILDYHKSIRHLRGGEATKQKYRKEDVEKPVRQ
>NC_004722.1|WP_000457980.1|5190959_5191961_-|rod-shape-determining-protein
MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVAIDRNSGKVLAVGEEARSMVGRTPGNIVAIRPLKDGVIANFEITEAMLKYFINKLDVKSFFSKPRILICCPTNITSVEQKAIREAAERSGGKTVFLEEEPKVAAVGAGMEIFQPSGNMVVDIGGGTTDIAVLSMGDIVTSSSIKMAGDKFDMEILNYIKRKYKLLIGERTSEDIKIKVGTVFPGARSEELEIRGRDMVTGLPRTITVCSEEITEALKENAAVIVQAAKGVLERTPPELSADIIDRGVILTGGGALLHGIDMLLAEELKVPVLIAENPMHCVAVGTGIMLENIDRLPKRALR
>NC_004722.1|WP_000931959.1|5190095_5190530_-|3-hydroxyacyl-ACP-dehydratase-FabZ
MLNIEQIKEIIPHRYPFLLVDKILEVDEGKRAVGIKNVSANEEFFNGHFPDYAVMPGVLIVEALAQVGAVAVLKKEENRGRLAFFAGIDNCRFKKQVRPGDQLRLEVEMTRVRGPIGKGKAIATVDGEVACEAEITFAIGDKKE
>NC_004722.1|WP_000467955.1|5189073_5189751_-|CpsD/CapB-family-tyrosine-protein-kinase
MFGRKKRKPLRQLITHKEPKSRITEQYRNIRTNIEFTSVDNHVRSIIVTSADPGDGKTTTISNLAVVFGQQGKKVLLIGADLRKPTIQNLFAIHSSNGLTNLLSGQAKLMQCIQKTDIENVYLMAAGPIPPNPAELLGSRAMDEALLEAYNMFDIILIDTPPVLAVTDAQILANKCDGIVLVVRSEKTEKDKIVKAKQILDKASGKILGVVLNDKREEKEQYGYY
>NC_004722.1|WP_000393128.1|5188066_5188810_-|capsular-polysaccharide-biosynthesis-protein
MEETISLKELFHILKKRLAMILVIAFGAAIVSAIISFFFMTPIYQSSTQILVNQKKQEGAAIQLGEIQSNIQLTNTYKVIIKSPVILDRVNEKLNLNMTAQALTKKINIANEKDSQVISVTAEDKDPKLARDIANATADVFKDEVAKIMNVDNVTVLSKAEVAENQSPIKPRPMLNVAIAFVVGLMASVGLAFLLEYLDNTVKKEEDVENLLGLPVLGIVARMDEETMNVKSHAPSSRKVRGQTIGS
>NC_004722.1|WP_001207193.1|5187375_5188077_-|CpsD/CapB-family-tyrosine-protein-kinase
MALNLFKKKKSHRQRRQLIAHQQPKSPISEQYRNIRTNIEFAAIDMNLHSLLVTSANPSEGKTTTTANMAVVFAQQGKKVLLIDADMRKPAMHQMFQVDNIFGLTNVLTHSERLEKCVQTTSIDNLSFLACGPIPPNPAELLGSKSMKELLGQAYSMYDLVIFDMPPILAVTDAQIMANVCDASILVVRSESTEKETAVKAKGLLESANGKLLGVVLNDREREQGLYYYYGAN
>NC_004722.1|WP_011110492.1|5186496_5187264_-|tyrosine-protein-phosphatase
MIDLHCHILPGIDDGAQTVTDSLAMAQKAASEGIHTIVATPHHQNGKYVNERTPIIHHVKQLNDELQQHNIPLTILPGQEVRLYGDLLEDYEAGKIVTLNETNKYIFIEFPSNHVPRYAEQLLYELRVKGMIPIIVHPERNAELIERPDKLYNIVNKGALTQVTAGSLLGKFGKKIKKFSLQLVEHNLTHMIASDAHNTTSRGFHLAESYELIEKEFGMNVMGDLKENPYLVISGKTIYKEDPEQIRRKKLFGIF
>NC_004722.1|WP_000757832.1|5185366_5186248_-|UTP--glucose-1-phosphate-uridylyltransferase-GalU
MKKVRKAIIPAAGLGTRFLPVTKAMPKEMLPIVDKPTIQYIVEEAIESGIEDIIIVTGKGKRAIEDHFDHSFELEQSLLEKGKHEMLEKVQASSKINIHYIRQKEPKGLGHAVWCARKFIGNEPFAVLLGDDIVQAETPCLRQLMDQYEGTQSSVIGVQTVPENETHRYGIIDPVEQNDRRYQVRQFVEKPEQGTAPSNLAIMGRYVLTPEIFMFLENQQTGAGGEIQLTDAIQRLNEVQRVFAYDFKGTRYDVGEKFGFIKTTIEMALQNEELNVELMKYMKELVKKEEVHS
>NC_004722.1|WP_033685340.1|5183496_5185305_-|polysaccharide-biosynthesis-protein
MSYRRRLSLLILLDSFIVLTAVYLSYWFIHPNVLNKIPMTVVISSITLLCSHHVFAAIYKLYNKAWEYASIGELKQIFKAITLSILVTAIVQQIINHDIYVRILAIAWMLHLLLIGGSRFVWRMFRDTYITKATDKKRTLIIGAGSAGTMVVRQLQHNKEADLYPIAFVDDDRNKQKLEIYNVPVIGTTNHIQEIVEDNDIEHIIIAIPSLNRGQINEIFEKCRKTKAKTQIVPMLEDLLDGKVSVNEFRDVQVEDLLGREPVQLDDKGIGEKIQDKTVLITGAGGSIGSEICRQILKYKPAKMVLLGHGENSIYHIEMELRTKYKEQAEFVTEIADIQDRNKIFEIMKKHKPFVVYHAAAHKHVPLMERNPEEAVKNNIIGTKNVAEAADTFGINTFVMVSTDKAVNPTNVMGATKRVAEMVVQHMAMISQTRFVAVRFGNVLGSRGSVIPLFKKQIQSGGPVTVTHPDITRYFMTIPEASRLVIQAGSLARGGELFVLDMGEPVKIADLAKNLIQLSGYSIEEIGIEYSGLRPGEKMYEELLNDNEIHKEQVFPKIHIGKAVLKDFESIQQFIDEFEQMSQESIRKTLLDFANNKVEVNS
>NC_004722.1|WP_000144450.1|5194046_5194751_-|ABC-transporter-permease
MTFSMRRVSAIFRKEVQDFKTNSQVLLMAFLPIILSFLFSRFGVGKEMLGITTITAFLFVAGFVQSMVIAEEKEKHTLRVLMLSPASSVEVLLGKSLLTSGLTMVICIANLFILDQLNINLPLVGLIFLCGTILFIVLGTMIGLLASSVPQTSIIGMPILMTMYLAVQFEPMVENKVIKTMIGYLPTSHIVKALKSLVGGAGFSSISGHVLNVAVWLIISLVVCLIVYKKKQLD
>NC_004722.1|WP_000170865.1|5194750_5195593_-|ABC-transporter-ATP-binding-protein
MTLAIEMKDVMKSFSGKTALRNVNIEVKQGEIFGFLGPSGSGKTTTVKILTSQLLHSVGTVRVLGKDITGPSSIDYKRIGILTDNSGLYERLSIYDNLLLFCDLYDCKKERIDEVLTQVNLLDDKKTPVKKLSKGMKQRVTLARAILHKPDILFLDEPTSALDPVNVQNIHKILKDLNEEGTTIFLTTHNMDEAETLCNRIAFLCGGEIVALDTPENLRLQYAKDQIEVVLKGKRKEVVQKDELGAKRISEWMNKGELLSIHSHEPTLGDIFIEVTGRGL
>NC_004722.1|WP_001185912.1|5195774_5196782_-|LytTR-family-transcriptional-regulator-DNA-binding-domain-containing-protein
MALLELKQLGKANQLPAIELEVEKGQCIVLQCNNHTAKVLHRIIIGEEEASTGNVLFEGEAIGKKNYSRIGFCFLKDEAYDRLKVKEYFKFLLGLYESKISIEEVVQSVGLLDKLNVKIEKLSFSEKRRLHIGRVMIHNPDLIILEEPEQNVDIESTVIIRKAIMKMKEQGKAIFITSSFLSDALSLTEDVYILNNDGVKKVEIEQEEAEKVDEEKVVQIIPQMKLERIPAKVNDKIILLDPMEIHFIETQNGVTHIHVREGDFVCALTLSELEERLTGFGFFRCHRSYLVNLQRVREVITWTRNSFSLILDDERKSSIPLSKGRMDELKGVIGL
>NC_004722.1|WP_000672662.1|5196882_5197902_-|stage-II-sporulation-protein-D
MKFSKPLFITVALLIALVIIVPAALVIPFAKAKVGEETASKTPPAIESIPAPGKVDTAVQVAVYREKQKKVETLPVEEYVTGVVASEMNASFEIEALKAQALAARTFVVQRMLSGGKKNNADVTDTVKDQVYKSKDELKKQWGNNYENNLKKIEEAVSKTAGQVLTYDGKPISASFFSTSNGRTENAADYWGNDYPYLKSVDSPWDQASPKFTSEQTFTVADFQKRLGVKVLADGKVGNIKDLTEGKRVKDVAFQGKTLTGKEVREKLDLRSSDFTWKQQGDKIIVTTKGFGHGVGMSQYGANGMAAEGKKYTDIVAHYYKGVAIKTMNDYEGKLMVKK
>NC_004722.1|WP_000411274.1|5198109_5199414_-|UDP-N-acetylglucosamine-1-carboxyvinyltransferase
MEKIIVRGGKRLNGTVRVEGAKNAVLPIIAAALLASDGKNVLSEVPVLSDVYTINEVLRHLNAEVVFENNQVTIDSSKELNIEAPFEYVRKMRASVQVMGPLLARNGRARIALPGGCAIGSRPIDQHLKGFEAMGAKVQVGNGFVEAYVEGELKGAKIYLDFPSVGATENIMSAATLAKGTTILENAAKEPEIVDLANFLNAMGAKVRGAGTGTIRIEGVDKLYGANHSIIPDRIEAGTFMVAAAITGGDILIENAVPEHLRSITAKMEEMGVKIIEENEGVRVIGPDKLKAVDIKTMPHPGFPTDMQSQMMALLLQADGTSMITETVFENRFMHVEEFRRMNADIKIEGRSVIMNGPNSLQGAEVAATDLRAAAALILAGLVSEGYTRVTELKHLDRGYVNFHKKLAALGATIERVNEKVEEVKEQEVSDLHA
>NC_004722.1|WP_002005985.1|5199453_5200164_-|YwmB-family-TATA-box-binding-protein
MKLKLKAILIVALSVVLFLVGYREMKPISDEQKMESMIKALEKNDAKVEKWSWLARETKTISNIHTFQKLLNDVKEKANIQKWEVEQSPDGYKATSYKKLSSYEERVVVTWSKENTKENTFIIFEVSGAKWDPKYVQNMNKIFSEKPIIYTCVQGVLNDKIEGVLQNKTNQVLKDLSARAIEQVEERAFVSVSAYNKKWDDALSTNREKINVQIAIRSTDNKDTIVVGTPIITSEY
>NC_004722.1|WP_000057889.1|5200209_5200446_-|DUF1146-domain-containing-protein
MAQLLGQQALIAIVSHLLFITITWWALQGIHIERLMKSGKVLQTRVLLILITIAIGTSVSNFFLDYLGYSKSLTYLVK
>NC_004722.1|WP_000367459.1|5200648_5202169_-|NADH-quinone-oxidoreductase-subunit-NuoN
MDMNTLFSLSWHLMVPEFIILGAAILLSICDLFFKLNHRYVALGAIAAIVLAIVSLITLYSEPAGDILNGSFVLDGFSKGFKTLLLGASALILCTAMSDDKKNPIEDKGEYYYLFLMALLGAMFMASSVDFITLFVGLELLSLSSYILVGIRKKSRASNEAAMKYVISGGIGTAITLFGMSYLYGITGSTNIVDMQKVLTGELASGIQLLLALAFLLLLVGLSFKIATVPFHMWAPDVYEGAATPVTAFLGTISKIAGFLLIIRLFLMIFASVLIQGDMQSLYGHMSIYIAVLASITMIVGNVVALKQYNIKRLFAYSGIAHAGYLLVPLVALSPFTMDSMWFYMLAYMLMNIGAFAIIHGLILQNNEENITIFTGLYKRSPFTAIMMTIFILSLAGIPGTAGFIGKINIFLGALHVEPAHYVLASIMMGTTVVSFVYYFRILQQMFFRTGETEERIRLPLNIKVVMSLCAISIVILGIMPMIGYNFFYEYFPLMKDFFFLGNVVQ
>NC_004722.1|WP_000998926.1|5202170_5203673_-|NADH-quinone-oxidoreductase-subunit-M
MNDLLLTFFIFSPLLGILLLVLTPKKELRTVRALGLFGTALPFGIAIVLACTYASGKNLSLFDEKMKWIKFGDFTAVDKRWFSIYYELGIDGLSLVMMVLTALLATLAAIAAFSIKRNLKAFYMLLLMLEIGMLGVFAAQNLMLFFIFFEITLPPMFLLIGKWGKLSSEKAAYSYLIYNGIGSAILLIVFSILFAKTGTTNIVELKEILRSVNAEGALVIPSSLQLSVFIAIMIAFAIKLPVFPLHRWMVNVHIEAHPAVVMLHAGVLLKIGAYGIIRFGKGLFPEYFHDVATLIAILGVINLLYGAFLALIQTDFRKVLAYSSISHMGIVLMGLASLNAPGTQGALFQVVSHGLIAALLFFLLGVIEQRFGTSDITALGGLAKSVPVLSGFFLAGGMASLGLPGMSGFVSEFLAFLGLFQGEPVIAAVGVIGIILTAVYVLRATLQVTFGKKEWEAKYDIHGWEYVPVLLLIFCIIAIGVMPEILGDPLQNTLKTLGVK
>NC_004722.1|WP_000568230.1|5203669_5205532_-|NADH-quinone-oxidoreductase-subunit-L
MIDYAWLIPLFPLVSFLLLIIFGKKIREGSSVLSIFFVFLSFILAVLVLIERFSEASVKHKWVWLRAGDVDISFGFEVTALGALMLFIVTLVSLLVHVYSKGYMKGDERLPTFYAYLGLFTFAMLGLVISTNLLQLYIFWELVGLGSFLLIGFYFFKEEAKAAAKKAFIMTRIGDVGLFIGMILIFWYAGSFEYDAIFRAIYTGDLPPYMITITAILIFIGAMGKSGQFPLHTWLPDAMEGPTPVSALIHAATMVAAGVYLVATMFPLFSASTVAMQTVAIVGAFTAIFAASIGLVQTDIKRVLAYSTVSQLGYMMLALGSAGYVAGIFHLTTHAFFKALLFLAAGSVIHAVHTQNINKMGGLQKKMKVTGTLFLIGTLAISGVPLLSGFFSKDEILAATWMNGNYVLFTLAVIAAFLTAFYMFRLYFLVFTGETKTKEEVHESPRVMTYPMIVLGVLAVVAGYINTPWFGTFLGDWLTKDVGFKVEETHGPVWIMIVATLVSFAGIALAYFIYRKKSISRNWAGGTETSLYNLLKEKYYVDELYNMTVIPITKGIAHVLRLFEVYVVEGIAVLIASVVKGTSNLGSKLQNGNVQVYGTVTVVSLAVLVIILLYTGGDLR

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Crispr_ID: NC_004722_3

CRISPR_ID

CRISPR_location

CRISPR_type

Repeat_type

Spacer_info

Cas_protein_info

CRISPR-Cas_info

NC_004722_3

5209576-5209935

Orphan

Consensus_repeat	Method
TGCTGCTGCCTTCGCCTTCGCTTTCGCTTTTTCTTCTTCCGTTACTTCTTCGGT	PILER-CR

3 spacers

The CRISPR arrays of NC_004722_3

>merge|NC_004722|3|5209576-5209935|PILER-CR
TGCTGCTGCCTTCGCCTTCGCTTTCGCTTTTTCTTCTTCCGTTACTTCTTCGGTTCCTTCTCTTTTCTGTTTCGCTAATGCTGCCGCTTTTGCTTTTGCGGCTGCTGCTGCCTTCGCCTTCGCTTTCGCTTTTTCTTCTTCCGTTACTTCTTCGGTTCCTTCTCTTTTCTGTTTCGCTAACGCCGCCGCTTTTGCTTTTGCGGCTGCTGCTGCCTTCGCCTTCGCTTTCGCTTTTTCTTCTTCCGTTACTTCTTCGGTTCCTTCTCTTTTCTGTTTCGCTAACGCCGCCGCTTTTGCTTTTGCGGCTGCTGCTGCCTTCGCCTTCGCTTTCGCTTTTTCTTCTTCCGTTACTTCTTCTGT

>NC_004722|3|1|5209576-5209935|PILER-CR
TGCTGCTGCCTTCGCCTTCGCTTTCGCTTTTTCTTCTTCCGTTACTTCTTCGGT	TCCTTCTCTTTTCTGTTTCGCTAATGCTGCCGCTTTTGCTTTTGCGGC
TGCTGCTGCCTTCGCCTTCGCTTTCGCTTTTTCTTCTTCCGTTACTTCTTCGGT	TCCTTCTCTTTTCTGTTTCGCTAACGCCGCCGCTTTTGCTTTTGCGGC
TGCTGCTGCCTTCGCCTTCGCTTTCGCTTTTTCTTCTTCCGTTACTTCTTCGGT	TCCTTCTCTTTTCTGTTTCGCTAACGCCGCCGCTTTTGCTTTTGCGGC
TGCTGCTGCCTTCGCCTTCGCTTTCGCTTTTTCTTCTTCCGTTACTTCTTCTGT

Protein	Signature genes	Signature genes Name	Protein_function
NC_004722.1\|WP_001012812.1\|5205869_5206394_-\|NADH-quinone-oxidoreductase-subunit-J	unknown	unknown	gnl\|CDD\|235844
NC_004722.1\|WP_000621434.1\|5207836_5208937_-\|NADH-quinone-oxidoreductase-subunit-NuoD	unknown	unknown	gnl\|CDD\|183437
NC_004722.1\|WP_000057889.1\|5200209_5200446_-\|DUF1146-domain-containing-protein	unknown	unknown	gnl\|CDD\|227173
NC_004722.1\|WP_000367459.1\|5200648_5202169_-\|NADH-quinone-oxidoreductase-subunit-NuoN	unknown	unknown	gnl\|CDD\|235603
NC_004722.1\|WP_000157696.1\|5217755_5218616_-\|F0F1-ATP-synthase-subunit-gamma	unknown	unknown	gnl\|CDD\|235535
NC_004722.1\|WP_000064683.1\|5220473_5221016_-\|F0F1-ATP-synthase-subunit-delta	unknown	unknown	gnl\|CDD\|235593
NC_004722.1\|WP_000179273.1\|5210686_5211055_-\|NADH-quinone-oxidoreductase-subunit-NuoA	unknown	unknown	gnl\|CDD\|169084
NC_004722.1\|WP_000573426.1\|5206835_5207837_-\|NADH-quinone-oxidoreductase-subunit-NuoH	unknown	unknown	gnl\|CDD\|235692
NC_004722.1\|WP_000847211.1\|5215686_5216088_-\|F0F1-ATP-synthase-subunit-epsilon	unknown	unknown	gnl\|CDD\|234796
NC_004722.1\|WP_000100077.1\|5205562_5205877_-\|NADH-quinone-oxidoreductase-subunit-NuoK	unknown	unknown	gnl\|CDD\|180218
NC_004722.1\|WP_000236331.1\|5210177_5210696_-\|NADH-quinone-oxidoreductase-subunit-NuoB	unknown	unknown	gnl\|CDD\|235797
NC_004722.1\|WP_001032595.1\|5216108_5217515_-\|F0F1-ATP-synthase-subunit-beta	unknown	unknown	gnl\|CDD\|236447
NC_004722.1\|WP_000622462.1\|5214062_5214707_-\|DUF975-family-protein	unknown	unknown	gnl\|CDD\|283754
NC_004722.1\|WP_000568230.1\|5203669_5205532_-\|NADH-quinone-oxidoreductase-subunit-L	unknown	unknown	gnl\|CDD\|235836
NC_004722.1\|WP_000027518.1\|5218953_5220462_-\|F0F1-ATP-synthase-subunit-alpha	unknown	unknown	gnl\|CDD\|236448
NC_004722.1\|WP_000745011.1\|5211309_5214039_+\|EAL-domain-containing-protein	unknown	unknown	gnl\|CDD\|236645
NC_004722.1\|WP_002005985.1\|5199453_5200164_-\|YwmB-family-TATA-box-binding-protein	unknown	unknown	gnl\|CDD\|370056
NC_004722.1\|WP_001142624.1\|5221012_5221519_-\|F0F1-ATP-synthase-subunit-B	unknown	unknown	gnl\|CDD\|180240
NC_004722.1\|WP_000998926.1\|5202170_5203673_-\|NADH-quinone-oxidoreductase-subunit-M	unknown	unknown	gnl\|CDD\|235622
NC_004722.1\|WP_000677191.1\|5206390_5206810_-\|NADH-quinone-oxidoreductase-subunit-NuoI	unknown	unknown	gnl\|CDD\|235637

Protein	Function_ID	Function_description	E-value
NC_004722.1\|WP_001012812.1\|5205869_5206394_-\|NADH-quinone-oxidoreductase-subunit-J	gnl\|CDD\|235844	PRK06638, PRK06638, NADH-quinone oxidoreductase subunit J.	3.84326e-52
NC_004722.1\|WP_000621434.1\|5207836_5208937_-\|NADH-quinone-oxidoreductase-subunit-NuoD	gnl\|CDD\|183437	PRK12322, PRK12322, NADH-quinone oxidoreductase subunit D.	0
NC_004722.1\|WP_000057889.1\|5200209_5200446_-\|DUF1146-domain-containing-protein	gnl\|CDD\|227173	COG4836, COG4836, Predicted membrane protein [Function unknown].	1.23409e-23
NC_004722.1\|WP_000367459.1\|5200648_5202169_-\|NADH-quinone-oxidoreductase-subunit-NuoN	gnl\|CDD\|235603	PRK05777, PRK05777, NADH-quinone oxidoreductase subunit NuoN.	4.09428e-151
NC_004722.1\|WP_000157696.1\|5217755_5218616_-\|F0F1-ATP-synthase-subunit-gamma	gnl\|CDD\|235535	PRK05621, PRK05621, F0F1 ATP synthase subunit gamma; Validated.	3.15452e-155
NC_004722.1\|WP_000064683.1\|5220473_5221016_-\|F0F1-ATP-synthase-subunit-delta	gnl\|CDD\|235593	PRK05758, PRK05758, F0F1 ATP synthase subunit delta; Validated.	1.16051e-62
NC_004722.1\|WP_000179273.1\|5210686_5211055_-\|NADH-quinone-oxidoreductase-subunit-NuoA	gnl\|CDD\|169084	PRK07756, PRK07756, NADH-quinone oxidoreductase subunit A.	1.38962e-71
NC_004722.1\|WP_000573426.1\|5206835_5207837_-\|NADH-quinone-oxidoreductase-subunit-NuoH	gnl\|CDD\|235692	PRK06076, PRK06076, NADH-quinone oxidoreductase subunit NuoH.	8.24893e-149
NC_004722.1\|WP_000847211.1\|5215686_5216088_-\|F0F1-ATP-synthase-subunit-epsilon	gnl\|CDD\|234796	PRK00571, atpC, F0F1 ATP synthase subunit epsilon; Validated.	2.68756e-56
NC_004722.1\|WP_000100077.1\|5205562_5205877_-\|NADH-quinone-oxidoreductase-subunit-NuoK	gnl\|CDD\|180218	PRK05715, PRK05715, NADH-quinone oxidoreductase subunit NuoK.	3.41849e-39
NC_004722.1\|WP_000236331.1\|5210177_5210696_-\|NADH-quinone-oxidoreductase-subunit-NuoB	gnl\|CDD\|235797	PRK06411, PRK06411, NADH-quinone oxidoreductase subunit NuoB.	2.04128e-108
NC_004722.1\|WP_001032595.1\|5216108_5217515_-\|F0F1-ATP-synthase-subunit-beta	gnl\|CDD\|236447	PRK09280, PRK09280, F0F1 ATP synthase subunit beta; Validated.	0
NC_004722.1\|WP_000622462.1\|5214062_5214707_-\|DUF975-family-protein	gnl\|CDD\|283754	pfam06161, DUF975, Protein of unknown function (DUF975). Family of uncharacterized bacterial proteins.	3.68012e-26
NC_004722.1\|WP_000568230.1\|5203669_5205532_-\|NADH-quinone-oxidoreductase-subunit-L	gnl\|CDD\|235836	PRK06590, PRK06590, NADH:ubiquinone oxidoreductase subunit L; Reviewed.	0
NC_004722.1\|WP_000027518.1\|5218953_5220462_-\|F0F1-ATP-synthase-subunit-alpha	gnl\|CDD\|236448	PRK09281, PRK09281, F0F1 ATP synthase subunit alpha; Validated.	0
NC_004722.1\|WP_000745011.1\|5211309_5214039_+\|EAL-domain-containing-protein	gnl\|CDD\|236645	PRK10060, PRK10060, cyclic di-GMP phosphodiesterase.	2.52187e-107
NC_004722.1\|WP_002005985.1\|5199453_5200164_-\|YwmB-family-TATA-box-binding-protein	gnl\|CDD\|370056	pfam08680, DUF1779, TATA-box binding. TATA-box_bdg is a family of bacterial proteins. YwmB from Bacillus subtilis contains a circularly permuted TATA-box binding protein-like fold. Jian-Xiang Liu, Qi Xie, Jun Lin. Protein Structural Data Mining and Evolutionary Bioinformatic Analysis on Domains of TATA-box Binding Protein-like Fold. Life Science Journal 2014; 11(2): 298-302 (not yet in PubMed 27-02-2014).	5.16446e-34
NC_004722.1\|WP_001142624.1\|5221012_5221519_-\|F0F1-ATP-synthase-subunit-B	gnl\|CDD\|180240	PRK05759, PRK05759, F0F1 ATP synthase subunit B; Validated.	5.78261e-43
NC_004722.1\|WP_000998926.1\|5202170_5203673_-\|NADH-quinone-oxidoreductase-subunit-M	gnl\|CDD\|235622	PRK05846, PRK05846, NADH:ubiquinone oxidoreductase subunit M; Reviewed.	2.00709e-177
NC_004722.1\|WP_000677191.1\|5206390_5206810_-\|NADH-quinone-oxidoreductase-subunit-NuoI	gnl\|CDD\|235637	PRK05888, PRK05888, NADH-quinone oxidoreductase subunit NuoI.	1.02543e-55

>NC_004722.1|WP_000621434.1|5207836_5208937_-|NADH-quinone-oxidoreductase-subunit-NuoD
MIRTEEMLLNVGPQHPSTHGVFRLVIKIDGEIIKEATPVIGYLHRGTEKIAESLQYTQIIPYTDRMDYLSAMTNNYVICHAVETMMGLEIPERAEYLRVLAMELGRIASHLVWWGTNLLDIGAVSPFLYAFREREMIINLLNELCGARLTFNYMRVGGVKWDAPDGWIEKVEEFVPYMREQLAGYHDLVSGNEIFLNRVKGVGIYSAEEAISYSLSGANLRCTGVNWDLRKDEPYSIYDRFDFDIPVGSVGDAWDRYVCRMQEIEESLKIVEQAVQQFPKDGAVLAKVPKIIKAPKGEAFVRIESPRGEIGCYIASDGKKEPYRLKFRRPSFYNLQILPKLLKGENIANLITILGGVDIVLGEVDG
>NC_004722.1|WP_000573426.1|5206835_5207837_-|NADH-quinone-oxidoreductase-subunit-NuoH
MIETLLQSPSSWTNFFIFFGLAVLLLFAVLGFVTYGILAERKVMGFMQGRIGPNQVGGRFGLLQTVADVLKLLLKEDSIPKAADKPLFILAPVIAFAPAFMVLAVIPFTDKFQFADIGVGLLYYIAVSGITTIGVVTGGWASNNKYSLLGGMRAAAQMISYEIPLVMSVIGIVLLAGSLNLNEIVAAQEKVWYIFVQPIGFVVFLIAAVAELNRTPFDLPEAESELVSGYHTEYSGFRWAFFMLSEYVYFFGMASLITVLFLGGWNPVMFLGFIPGAVWFALKFSSVVFLLIWFRVTFPRIRGDQLMEFGWKVLLPIALANIFLTALIKELFF
>NC_004722.1|WP_000677191.1|5206390_5206810_-|NADH-quinone-oxidoreductase-subunit-NuoI
MKGLFKGLKYTLSNLSKKKVTYDYPNQPLPLPDRFRGIQKFYPEKCIVCNQCSNICPTDCIQLTGKKHPDPTKKGKIIDTYDINFEICILCDLCTEVCPTEAIVMTNNFELAEYSRDDLFKNLQWLDENDENVRKENKA
>NC_004722.1|WP_001012812.1|5205869_5206394_-|NADH-quinone-oxidoreductase-subunit-J
MNGEFVAFFILSLSAIIGGVLMLNLTKVMHMMLALVLTFLSIAGLYFLLSAEFIGVAQILLYSGAITIIMIFGIMLTKHNAENESRLTLRKWIIFFAVVAFGAVMYFAVNNVDFANESTQGSLPLHENNTLQIGTLLYSKYIIPFELTSVILLVALVGAIILAKKDEKEEDSNE
>NC_004722.1|WP_000100077.1|5205562_5205877_-|NADH-quinone-oxidoreductase-subunit-NuoK
MSSVPASAYLTLAIILFCIGLFGALTKRNTVIVLVCIELMLNAANLNLVAFSKLGLFPNLTGQIFSLFTMAVAAAEAALGLAILIALYRNRTTVQVDEMDTLKG
>NC_004722.1|WP_000568230.1|5203669_5205532_-|NADH-quinone-oxidoreductase-subunit-L
MIDYAWLIPLFPLVSFLLLIIFGKKIREGSSVLSIFFVFLSFILAVLVLIERFSEASVKHKWVWLRAGDVDISFGFEVTALGALMLFIVTLVSLLVHVYSKGYMKGDERLPTFYAYLGLFTFAMLGLVISTNLLQLYIFWELVGLGSFLLIGFYFFKEEAKAAAKKAFIMTRIGDVGLFIGMILIFWYAGSFEYDAIFRAIYTGDLPPYMITITAILIFIGAMGKSGQFPLHTWLPDAMEGPTPVSALIHAATMVAAGVYLVATMFPLFSASTVAMQTVAIVGAFTAIFAASIGLVQTDIKRVLAYSTVSQLGYMMLALGSAGYVAGIFHLTTHAFFKALLFLAAGSVIHAVHTQNINKMGGLQKKMKVTGTLFLIGTLAISGVPLLSGFFSKDEILAATWMNGNYVLFTLAVIAAFLTAFYMFRLYFLVFTGETKTKEEVHESPRVMTYPMIVLGVLAVVAGYINTPWFGTFLGDWLTKDVGFKVEETHGPVWIMIVATLVSFAGIALAYFIYRKKSISRNWAGGTETSLYNLLKEKYYVDELYNMTVIPITKGIAHVLRLFEVYVVEGIAVLIASVVKGTSNLGSKLQNGNVQVYGTVTVVSLAVLVIILLYTGGDLR
>NC_004722.1|WP_000998926.1|5202170_5203673_-|NADH-quinone-oxidoreductase-subunit-M
MNDLLLTFFIFSPLLGILLLVLTPKKELRTVRALGLFGTALPFGIAIVLACTYASGKNLSLFDEKMKWIKFGDFTAVDKRWFSIYYELGIDGLSLVMMVLTALLATLAAIAAFSIKRNLKAFYMLLLMLEIGMLGVFAAQNLMLFFIFFEITLPPMFLLIGKWGKLSSEKAAYSYLIYNGIGSAILLIVFSILFAKTGTTNIVELKEILRSVNAEGALVIPSSLQLSVFIAIMIAFAIKLPVFPLHRWMVNVHIEAHPAVVMLHAGVLLKIGAYGIIRFGKGLFPEYFHDVATLIAILGVINLLYGAFLALIQTDFRKVLAYSSISHMGIVLMGLASLNAPGTQGALFQVVSHGLIAALLFFLLGVIEQRFGTSDITALGGLAKSVPVLSGFFLAGGMASLGLPGMSGFVSEFLAFLGLFQGEPVIAAVGVIGIILTAVYVLRATLQVTFGKKEWEAKYDIHGWEYVPVLLLIFCIIAIGVMPEILGDPLQNTLKTLGVK
>NC_004722.1|WP_000367459.1|5200648_5202169_-|NADH-quinone-oxidoreductase-subunit-NuoN
MDMNTLFSLSWHLMVPEFIILGAAILLSICDLFFKLNHRYVALGAIAAIVLAIVSLITLYSEPAGDILNGSFVLDGFSKGFKTLLLGASALILCTAMSDDKKNPIEDKGEYYYLFLMALLGAMFMASSVDFITLFVGLELLSLSSYILVGIRKKSRASNEAAMKYVISGGIGTAITLFGMSYLYGITGSTNIVDMQKVLTGELASGIQLLLALAFLLLLVGLSFKIATVPFHMWAPDVYEGAATPVTAFLGTISKIAGFLLIIRLFLMIFASVLIQGDMQSLYGHMSIYIAVLASITMIVGNVVALKQYNIKRLFAYSGIAHAGYLLVPLVALSPFTMDSMWFYMLAYMLMNIGAFAIIHGLILQNNEENITIFTGLYKRSPFTAIMMTIFILSLAGIPGTAGFIGKINIFLGALHVEPAHYVLASIMMGTTVVSFVYYFRILQQMFFRTGETEERIRLPLNIKVVMSLCAISIVILGIMPMIGYNFFYEYFPLMKDFFFLGNVVQ
>NC_004722.1|WP_000057889.1|5200209_5200446_-|DUF1146-domain-containing-protein
MAQLLGQQALIAIVSHLLFITITWWALQGIHIERLMKSGKVLQTRVLLILITIAIGTSVSNFFLDYLGYSKSLTYLVK
>NC_004722.1|WP_002005985.1|5199453_5200164_-|YwmB-family-TATA-box-binding-protein
MKLKLKAILIVALSVVLFLVGYREMKPISDEQKMESMIKALEKNDAKVEKWSWLARETKTISNIHTFQKLLNDVKEKANIQKWEVEQSPDGYKATSYKKLSSYEERVVVTWSKENTKENTFIIFEVSGAKWDPKYVQNMNKIFSEKPIIYTCVQGVLNDKIEGVLQNKTNQVLKDLSARAIEQVEERAFVSVSAYNKKWDDALSTNREKINVQIAIRSTDNKDTIVVGTPIITSEY
>NC_004722.1|WP_000236331.1|5210177_5210696_-|NADH-quinone-oxidoreductase-subunit-NuoB
MVINFEELHPNERAELERNIFFSTLEQLKGWARSNSLWPMTFGLACCAIEMMGVGSSHYDLDRFGSFFRTSPRQSDVMIVSGTVTKKMAPIVRRLYDQMPEPKWVIAMGSCATAGGPYVNSYAVVKGVDQIVPVDVYIPGCPPNPAALIYGINKLKEKIRYEAKTGKQVTNK
>NC_004722.1|WP_000179273.1|5210686_5211055_-|NADH-quinone-oxidoreductase-subunit-NuoA
MASVYENSYMIVLIFLLLGILLPVVALTLGRMLRPNKPSAAKATTYESGIEPFHDANIRFHARYYIFALLFVIFDVETLFLYPWAVAYDKLGLFALIEMLIFVVMLLVGLAYAWKKKVLQWL
>NC_004722.1|WP_000745011.1|5211309_5214039_+|EAL-domain-containing-protein
MKKQTHVSILISIVLLSITLHYVAMPFVYEYSFPFQLLIGTSTLLIDIIACSYILYFSNMKEGLSRLFWIILSVGALSYFIGDIVVAYQRLIVKDFYTFVDPSDFFYLLFLVSFTFAFLYEIIYNRDLLEKLFMLCDICIIVTAQFTLSYYLLIERTIHIFTTSYIDIFVQLTYPMADLLFLLIGINLLFKPLSLLPKKVGALLGSALILYATTDAIYAYIKYFIPEYSMFTVTPFYQVTLVLVAIACILHTKKPEKQEQVLLTPKIGESIRLSLPYISVVMLIVFILVEYVFAPIIVIGLIITFSFVLIRHSLVRKQNKILLIAQMQFNSELEKQIKLRTEDLVEQKNELYHNQQMFKSLYEHHPDPIFTLDLYGNFLKVNNAGTTLLGYQTNELLNQPYYSLIYEEDLEEMINAFHRVKKGYSISLEIRAYHKNRDIYYLHVTAVPIFLKEKISGVYLMIKDITESKQQQEQINFLAYHDTLTELANRRAFHQHLEQAIARAKISKKPFAVMFLDLDRFKVINDTLGHRVGDLLLIAVAKRLERIATSNMKLARLAGDEFTILIENYKKKPDVQKIADRIVAAMNEPFEIENQHLQISPSIGIAIYPEAGEDALSILQHADMAMYEAKNKGKNGSSLYTKELYKKMERKARIEKDLPIALVNKEFYLVYQPQIDTTTNKIIGAEALIRWKHPLLGDISPCEFIPIVEETPQVVPLGHWVLQEACLQLKIWHTFGYQNLKISVNLSAKEFRQDQLIENISQILNDVQVDPKYVTLELTERIAMIDEKETLLRLKQLKEYGIQTSIDDFGTGYSSLAYLSIFPIDTLKVPREFTQLADHRPEERAIVSTILSLANTLNLSVVAEGIETEKQLKFLQKHNCKYMQGYYFSKPLTSNQFIKFLQKTPSMNK
>NC_004722.1|WP_000622462.1|5214062_5214707_-|DUF975-family-protein
MISDLKGEALDSLEGKWGLAVGATLLISILITAFSFSVDWGFSLIFGWQKTNGSLSTNILSFFVTGPLTLGGYYLGLNILREKQASIGNVFIWFSEGKRFLKSFLLYLLVNLYLFLWTLLFIIPGIIKSFSYAMTYFIINDHPEYSLNQAITESRRMMDGHKMEYFILCLSFIGWFILSCITLGIGFLWLIPYFYTTSAAFYEEIAEEYYEKKI
>NC_004722.1|WP_000847211.1|5215686_5216088_-|F0F1-ATP-synthase-subunit-epsilon
MKTFPVSIVTPDGPVYEKEVEMVSVKAESGEMGILPGHIPTVAPLKISAVRLKNGGHTDYVAVSGGFIEVRPDKVTVLSSSAEEANHIDIHRANEAKRRAEQRLQDKQAHVDFKRAEMALQRAVNRLNVSDMK
>NC_004722.1|WP_001032595.1|5216108_5217515_-|F0F1-ATP-synthase-subunit-beta
MNKGRVTQIMGPVVDVKFDGGKLPEIYNALTVKQSNENGSMNLTFEVALHLGDDTVRTVAMSSTDGLVRGTEVEDTGKAISVPVGDATLGRVFNVLGDAIDLDGELPADVHRDPIHRQAPAFEELSTKVEILETGIKVVDLLAPYIKGGKIGLFGGAGVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLYHEMSDSGVIKKTAMVFGQMNEPPGARQRVALTGLTMAEHFRDEQGQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGQLQERITSTNKGSITSIQAVYVPADDYTDPAPATTFAHLDATTNLERRLTQMGIYPAVDPLASTSRALSPEIVGEEHYEVARQVQQTLQRYKELQDIIAILGMDELSEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKNTVSGFKEILEGKYDDLPEDAFRLVGGIEEVIENAKKMMA
>NC_004722.1|WP_000157696.1|5217755_5218616_-|F0F1-ATP-synthase-subunit-gamma
MASLRDIKAKINSTKKTSQITKAMEMVSASKLNRAEQNAKSFVPYMEKIQEVVASIAQGSKGINHPMLNARPVKRTGYIVITSDRGLAGGYNSNVLRTVSNVIRERHNMDSNQYSIIVLGRLGRDYLKRRGFNIIDEVVGLSDHPSFTDIKDLASRAIAMFADGAYDELYIYYNHYVSKISQEVTENKILPLTDVASDKPTTAYEFEPSEEEILKVLLPQYAESLVYGALLDGKASEHAARMTAMKSATDNAMEVIDSLTLSFNRARQAAITQEITEIVGGAAALE
>NC_004722.1|WP_000027518.1|5218953_5220462_-|F0F1-ATP-synthase-subunit-alpha
MSIRAEEISALIKQQIENYQSEIEVSDVGTVIQVGDGIARAHGLDNVMAGELVEFSNGVMGLAQNLEENNVGIIILGPYTEIREGDEVRRTGRIMQVPVGKELIGRVVNPLGQPVDGLGPINTTNTRPIESPAPGVMDRKSVHEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTAVALDTIINQKDEDMICIYVAIGQKESTVRNVVETLRKHGALEYTIVVTASASQPAPLLYLAPYAGVTMGEEFMYNGKHVLVVYDDLSKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFIETQAGDVSAYIPTNVISITDGQIFLQSDLFFSGVRPAIDAGTSVSRVGGSAQIKAMSKVSGTLRLDLASYRELEAFAQFGSDLDKATQAKLNRGARTVEVLKQGLHKPLRVEKQVIILYALTRGFLDDIPVVDITRFEEEFHAWLDSNATDLLEEIRTTKKLADDDKFAAAINGFKKVFVASE
>NC_004722.1|WP_000064683.1|5220473_5221016_-|F0F1-ATP-synthase-subunit-delta
MSNGIVAKRYAVALFKIAKEKHVLEMFEEELRLVQNVYVKNGELHSFLTQPNISKEQKKTFLANVFGSVSESILNTLYILIDNKRIDILPEIADEYVVLANEERNVADATVYSTRLLSEEEKLNIAEAFAKRTGKDAIRVKNVVDEDLLGGIKVRIGNRIYDGSLQGKLARIQRELMKNR
>NC_004722.1|WP_001142624.1|5221012_5221519_-|F0F1-ATP-synthase-subunit-B
MPTLLLGASIPFGTIAYTLFIFLLLLVMLRKFAWGPLMGIMKEREEHVANEIDAAERNNAEAKKLVEEQREMLKQSRVEAQELIERAKKQAVDQKDVIVAAAKEEAESIKASAVQEIQREKEQAIAALQEQVASLSVQIASKVIEKELKEEDQVKLIRDYIKEVGEAR

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Click the colored protein region to show detailed information

Self-targeting detection

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_ID	Protospacer_location	Mismatch	Identity

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_004722_2	2.2\|5193102\|34\|NC_004722\|CRISPRCasFinder	5193102-5193135	34	NC_025153	Arcobacter butzleri strain AC1119 plasmid AB-1119-LD, complete sequence	2000-2033	7	0.794
NC_004722_1	1.1\|3307729\|37\|NC_004722\|CRISPRCasFinder	3307729-3307765	37	AP014498	Uncultured Mediterranean phage uvMED isolate uvMED-GF-C73-MedDCM-OCT-S34-C64, * SEQUENCING IN PROGRESS *, 4 ordered pieces	15061-15097	8	0.784
NC_004722_1	1.1\|3307729\|37\|NC_004722\|CRISPRCasFinder	3307729-3307765	37	MK373793	Escherichia phage vB_EcoS_MM01, complete genome	10030-10066	8	0.784
NC_004722_1	1.1\|3307729\|37\|NC_004722\|CRISPRCasFinder	3307729-3307765	37	MN694423	Marine virus AFVG_250M1001, complete genome	26233-26269	8	0.784
NC_004722_1	1.1\|3307729\|37\|NC_004722\|CRISPRCasFinder	3307729-3307765	37	HQ615693	Synechococcus phage S-CRM01, complete genome	25676-25712	8	0.784
NC_004722_2	2.1\|5193048\|31\|NC_004722\|CRISPRCasFinder	5193048-5193078	31	JX238501	Bacillus phage phiAGATE, complete genome	124559-124589	8	0.742
NC_004722_1	1.1\|3307729\|37\|NC_004722\|CRISPRCasFinder	3307729-3307765	37	MH051259	Mycobacterium phage TNguyen7, complete genome	2214-2250	9	0.757
NC_004722_1	1.1\|3307729\|37\|NC_004722\|CRISPRCasFinder	3307729-3307765	37	KY464936	Mycobacterium phage Idleandcovert, complete genome	2216-2252	9	0.757

1. spacer 2.2|5193102|34|NC_004722|CRISPRCasFinder matches to NC_025153 (Arcobacter butzleri strain AC1119 plasmid AB-1119-LD, complete sequence) position: , mismatch: 7, identity: 0.794

cttgtcttctgttttactttccggtttcgtgctc	CRISPR spacer
ctcatattctgttttactttccgttttagtgatt	Protospacer
**..* ***************** *** *** *.

2. spacer 1.1|3307729|37|NC_004722|CRISPRCasFinder matches to AP014498 (Uncultured Mediterranean phage uvMED isolate uvMED-GF-C73-MedDCM-OCT-S34-C64, *** SEQUENCING IN PROGRESS ***, 4 ordered pieces) position: , mismatch: 8, identity: 0.784

accccttgtggaccttggattccttgtggaccttgag	CRISPR spacer
gatgcatctgaaccttggattccttgtgtaccttgag	Protospacer
. . * * **.***************** ********

3. spacer 1.1|3307729|37|NC_004722|CRISPRCasFinder matches to MK373793 (Escherichia phage vB_EcoS_MM01, complete genome) position: , mismatch: 8, identity: 0.784

accccttgtggaccttggattccttgtggaccttgag	CRISPR spacer
aagccagctggaccttgaattccttgcggaccttgaa	Protospacer
*  **   *********.********.*********.

4. spacer 1.1|3307729|37|NC_004722|CRISPRCasFinder matches to MN694423 (Marine virus AFVG_250M1001, complete genome) position: , mismatch: 8, identity: 0.784

accccttgtggaccttggattccttgtggaccttgag	CRISPR spacer
gcgccggttggcccttggattccttgtgggccttgcg	Protospacer
.* **   *** *****************.***** *

5. spacer 1.1|3307729|37|NC_004722|CRISPRCasFinder matches to HQ615693 (Synechococcus phage S-CRM01, complete genome) position: , mismatch: 8, identity: 0.784

--accccttgtggaccttggattccttgtggaccttgag	CRISPR spacer
ttacccccaac--accttgaaatccttgtggaccttgag	Protospacer
  *****. ..  ******.* *****************

6. spacer 2.1|5193048|31|NC_004722|CRISPRCasFinder matches to JX238501 (Bacillus phage phiAGATE, complete genome) position: , mismatch: 8, identity: 0.742

ttcttcttttttgtcactagttgaaccgctt	CRISPR spacer
ctaaccttttttgccactagttaaaccgccc	Protospacer
.*  .********.********.******..

7. spacer 1.1|3307729|37|NC_004722|CRISPRCasFinder matches to MH051259 (Mycobacterium phage TNguyen7, complete genome) position: , mismatch: 9, identity: 0.757

accccttgtggaccttggattccttgtggaccttgag	CRISPR spacer
tcaccctcgggaccttggatgccctgtggaccttgtt	Protospacer
 * **.*  *********** **.***********

8. spacer 1.1|3307729|37|NC_004722|CRISPRCasFinder matches to KY464936 (Mycobacterium phage Idleandcovert, complete genome) position: , mismatch: 9, identity: 0.757

accccttgtggaccttggattccttgtggaccttgag	CRISPR spacer
tcaccctcgggaccttggatgccctgtggaccttgtt	Protospacer
 * **.*  *********** **.***********

Prophage detection

Region

Region Position

Protein_number

Hit_taxonomy

Key_proteins

Att_site

Prophage annotation

DBSCAN-SWA_1

257502 : 265450

uncultured_virus(33.33%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000917311.1\|257502_257787_+	co-chaperone GroES	A0A221S3C8	uncultured_virus	1.2e-20	54.8
WP_001029995.1\|257825_259460_+	chaperonin GroEL	A0A219YK78	uncultured_virus	4.5e-157	57.8
WP_162840109.1\|259863_261405_+	glutamine-hydrolyzing GMP synthase	A0A1V0SH76	Hokovirus	8.9e-22	31.7
WP_000833082.1\|261789_263115_+	NCS2 family permease	A0A0R6PHV4	Moraxella_phage	6.4e-45	30.1
WP_000929879.1\|263259_263961_+	response regulator transcription factor	W8CYM9	Bacillus_phage	9.5e-40	36.9
WP_000719220.1\|263944_265450_+	aminopeptidase AmpS	W8CYF6	Bacillus_phage	1.2e-31	30.3

DBSCAN-SWA_2

300615 : 308991

Synechococcus_phage(50.0%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000625682.1\|300615_301923_+	adenylosuccinate lyase	A0A2H4UUU6	Bodo_saltans_virus	4.9e-21	25.3
WP_001170544.1\|302011_302731_+	phosphoribosylaminoimidazolesuccinocarboxamide synthase	G8EYA2	Synechococcus_phage	4.0e-49	44.3
WP_000278823.1\|302723_302978_+	phosphoribosylformylglycinamidine synthase subunit PurS	NA	NA	NA	NA
WP_000666774.1\|302974_303658_+	phosphoribosylformylglycinamidine synthase subunit PurQ	NA	NA	NA	NA
WP_000055555.1\|303641_305861_+	phosphoribosylformylglycinamidine synthase II	A6N228	Microbacterium_phage	8.8e-164	41.2
WP_000879025.1\|305845_307261_+	amidophosphoribosyltransferase	A0A0M3SGR2	Mollivirus	3.3e-55	35.4
WP_001262439.1\|307366_308407_+	phosphoribosylformylglycinamidine cyclo-ligase	A0A0E3F760	Synechococcus_phage	1.2e-67	45.9
WP_000088589.1\|308403_308991_+	phosphoribosylglycinamide formyltransferase	M4QRX9	Synechococcus_phage	9.1e-28	37.4

DBSCAN-SWA_3

1825004 : 1831579

Staphylococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001233224.1\|1825004_1825259_+	hypothetical protein	I7ILU4	Staphylococcus_phage	1.0e-36	92.9
WP_000658753.1\|1825651_1826053_+	hypothetical protein	NA	NA	NA	NA
WP_000804493.1\|1826219_1826528_+	hypothetical protein	NA	NA	NA	NA
WP_000741276.1\|1826568_1826721_+	hypothetical protein	NA	NA	NA	NA
WP_000364356.1\|1826754_1827000_+	hypothetical protein	NA	NA	NA	NA
WP_001246457.1\|1827045_1827276_+	hypothetical protein	A0A2H4JCC5	uncultured_Caudovirales_phage	2.0e-18	66.2
WP_000680282.1\|1827278_1827866_+	HNH endonuclease	A0A1S5SAF6	Streptococcus_phage	8.3e-37	41.8
WP_000053746.1\|1827898_1828324_+	hypothetical protein	S5MUC4	Brevibacillus_phage	1.5e-11	54.7
WP_000101076.1\|1828310_1828955_+	hypothetical protein	NA	NA	NA	NA
WP_001057582.1\|1828969_1829152_+	hypothetical protein	NA	NA	NA	NA
WP_000805619.1\|1829148_1829466_+	transglycosylase	NA	NA	NA	NA
WP_000026878.1\|1829482_1830424_+	hypothetical protein	NA	NA	NA	NA
WP_000790090.1\|1830426_1830573_+	BC1881 family protein	NA	NA	NA	NA
WP_001202994.1\|1830698_1830896_+	hypothetical protein	NA	NA	NA	NA
WP_000659529.1\|1830920_1831301_+	hypothetical protein	A0A088F787	Idiomarinaceae_phage	1.6e-25	60.2
WP_000843022.1\|1831297_1831579_+	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	A0A2I7SC16	Paenibacillus_phage	3.6e-14	60.7

DBSCAN-SWA_4

1834921 : 1866036

Bacillus_phage(85.71%)

portal,terminase,holin,tail

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000323343.1\|1834921_1836637_+\|terminase	phage terminase large subunit	A0A142F1L6	Bacillus_phage	3.3e-150	52.7
WP_001265884.1\|1836653_1838171_+\|portal	phage portal protein	A0A142F1L7	Bacillus_phage	4.4e-66	29.6
WP_002195384.1\|1838229_1839012_+	phage scaffolding protein	Q4ZC70	Staphylococcus_virus	2.8e-08	39.1
WP_001145076.1\|1839071_1840196_+	DUF5309 family protein	NA	NA	NA	NA
WP_000027968.1\|1840245_1840470_+	hypothetical protein	NA	NA	NA	NA
WP_000868476.1\|1840498_1840840_+	hypothetical protein	NA	NA	NA	NA
WP_001285264.1\|1840844_1841651_+	hypothetical protein	NA	NA	NA	NA
WP_000954647.1\|1841654_1842029_+	hypothetical protein	NA	NA	NA	NA
WP_001222697.1\|1842028_1842388_+	hypothetical protein	NA	NA	NA	NA
WP_000930921.1\|1842390_1842798_+	hypothetical protein	NA	NA	NA	NA
WP_000852562.1\|1842811_1843318_+\|tail	phage major tail protein, TP901-1 family	NA	NA	NA	NA
WP_000443958.1\|1843341_1843701_+	hypothetical protein	A0A0A7AQ61	Bacillus_phage	4.1e-39	82.9
WP_000762691.1\|1843687_1843903_+	hypothetical protein	H0USV9	Bacillus_phage	2.3e-29	97.1
WP_000818630.1\|1843970_1844348_+	hypothetical protein	NA	NA	NA	NA
WP_000955319.1\|1844437_1844692_+	hypothetical protein	NA	NA	NA	NA
WP_164928343.1\|1844728_1848625_+\|tail	phage tail tape measure protein	A6M961	Geobacillus_virus	5.5e-12	48.8
WP_001260205.1\|1850133_1855110_+\|tail	tail fiber domain-containing protein	I7ILV8	Bacillus_phage	0.0e+00	62.3
WP_000398730.1\|1855201_1855438_+	hemolysin XhlA family protein	A0A0A7AQY5	Bacillus_phage	2.5e-08	97.4
WP_000462607.1\|1855437_1855677_+\|holin	holin	A0A0A7AR38	Bacillus_phage	2.2e-33	96.2
WP_000753412.1\|1855673_1856738_+	N-acetylmuramoyl-L-alanine amidase	A0A0A7AQV3	Bacillus_phage	9.9e-198	94.9
WP_000607108.1\|1857319_1858936_-	SIR2 family protein	A0A1S5SA14	Streptococcus_phage	9.9e-32	30.3
WP_000448740.1\|1859008_1859335_-	hypothetical protein	A0A0S2GLG3	Bacillus_phage	6.2e-18	45.4
WP_001999824.1\|1859411_1859678_-	helix-turn-helix transcriptional regulator	A0A288WFZ7	Bacillus_phage	4.1e-20	61.8
WP_001169624.1\|1859831_1859954_+	DUF3961 domain-containing protein	Q3HKZ4	Bacillus_phage	9.7e-09	62.2
WP_000669088.1\|1860591_1860792_-	helix-turn-helix transcriptional regulator	Q2I8E4	Bacillus_phage	1.4e-12	54.5
WP_001247348.1\|1860977_1861247_+	hypothetical protein	NA	NA	NA	NA
WP_001267619.1\|1861243_1861546_+	hypothetical protein	A0A288WG08	Bacillus_phage	3.0e-27	58.2
WP_000170794.1\|1861542_1861725_+	hypothetical protein	Q2I8E2	Bacillus_phage	6.3e-20	83.3
WP_164928327.1\|1861840_1862203_+	hypothetical protein	A0A288WFS1	Bacillus_phage	1.8e-42	70.8
WP_015971207.1\|1862229_1863024_+	hypothetical protein	H0USY1	Bacillus_phage	1.4e-84	59.8
WP_011110021.1\|1862965_1863589_+	replication-relaxation family protein	H0USY2	Bacillus_phage	1.1e-95	80.6
WP_001261512.1\|1863588_1863822_+	hypothetical protein	NA	NA	NA	NA
WP_000765496.1\|1863829_1864018_+	hypothetical protein	NA	NA	NA	NA
WP_000200736.1\|1864037_1864253_+	hypothetical protein	NA	NA	NA	NA
WP_000273126.1\|1864563_1866036_+	recombinase family protein	Q3HKZ2	Bacillus_phage	5.9e-140	52.2

DBSCAN-SWA_5

1899962 : 1908126

Bacillus_phage(71.43%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000755498.1\|1899962_1901255_+	C40 family peptidase	A0A1V0DZX6	Clostridioides_phage	3.5e-11	31.5
WP_001194309.1\|1901354_1902119_-	alpha/beta hydrolase	NA	NA	NA	NA
WP_164928328.1\|1902359_1902530_+	hypothetical protein	W8CYL7	Bacillus_phage	3.2e-18	92.3
WP_011110029.1\|1902504_1904121_+	ABC transporter ATP-binding protein	W8CYL7	Bacillus_phage	6.2e-244	97.4
WP_000612413.1\|1904206_1904884_+	response regulator transcription factor	W8CYM9	Bacillus_phage	2.5e-122	98.7
WP_001231630.1\|1904880_1905954_+	HAMP domain-containing sensor histidine kinase	W8CYF6	Bacillus_phage	1.5e-185	97.2
WP_000818985.1\|1906243_1906963_+	3-ketoacyl-ACP reductase	W8CYX9	Bacillus_phage	5.9e-61	100.0
WP_001258500.1\|1907253_1908126_+	aminoglycoside 6-adenylyltransferase	A0A1X9I6F2	Streptococcus_phage	7.4e-66	45.1

DBSCAN-SWA_6

2500481 : 2595714

101

Bacillus_phage(80.49%)

capsid,protease,holin,tail,portal,tRNA,terminase,transposase,integrase,head,bacteriocin

attL 2541349:2541367|attR 2621518:2621536

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000448287.1\|2500481_2501138_-\|protease	CPBP family intramembrane metalloprotease	NA	NA	NA	NA
WP_000290886.1\|2501459_2501663_+	hypothetical protein	NA	NA	NA	NA
WP_002195526.1\|2501690_2501933_-	hypothetical protein	NA	NA	NA	NA
WP_000438854.1\|2502043_2502970_+	zinc-binding dehydrogenase	NA	NA	NA	NA
WP_000689435.1\|2503051_2503909_+	NAD(P)-dependent oxidoreductase	NA	NA	NA	NA
WP_001021692.1\|2503964_2504465_+	DUF421 domain-containing protein	NA	NA	NA	NA
WP_000397610.1\|2504721_2505351_+	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_001079448.1\|2505603_2506305_-	class I SAM-dependent methyltransferase	NA	NA	NA	NA
WP_000492432.1\|2506301_2507204_-	SMP-30/gluconolactonase/LRE family protein	NA	NA	NA	NA
WP_000551042.1\|2507346_2507517_+	DUF2197 domain-containing protein	NA	NA	NA	NA
WP_000558598.1\|2507924_2509478_+\|tRNA	lysine--tRNA ligase	NA	NA	NA	NA
WP_001128401.1\|2509512_2509965_-	cell wall hydrolase	NA	NA	NA	NA
WP_000285667.1\|2510115_2511030_+	acetamidase/formamidase family protein	NA	NA	NA	NA
WP_000239010.1\|2511157_2511865_+	response regulator transcription factor	NA	NA	NA	NA
WP_002183605.1\|2511861_2512845_+	sensor histidine kinase	NA	NA	NA	NA
WP_000376264.1\|2513081_2513708_-	hypothetical protein	NA	NA	NA	NA
WP_000661373.1\|2514265_2515894_+	ABC-F type ribosomal protection protein	A0A1B0RXA0	Streptococcus_phage	7.8e-53	34.3
WP_000343078.1\|2515914_2516499_+	GNAT family N-acetyltransferase	NA	NA	NA	NA
WP_000404266.1\|2516757_2517528_+	ABC transporter ATP-binding protein	G9BWD6	Planktothrix_phage	1.2e-32	39.9
WP_000144161.1\|2517502_2519437_+	ABC transporter permease	NA	NA	NA	NA
WP_000744466.1\|2519506_2520178_+	hypothetical protein	NA	NA	NA	NA
WP_001165491.1\|2520243_2520585_-	DUF3914 domain-containing protein	NA	NA	NA	NA
WP_000701770.1\|2522194_2523220_+	homoserine dehydrogenase	NA	NA	NA	NA
WP_000471646.1\|2523309_2524758_+	PLP-dependent aminotransferase family protein	NA	NA	NA	NA
WP_011110115.1\|2524772_2525678_+	D-alanine--D-alanine ligase	NA	NA	NA	NA
WP_000144509.1\|2525984_2526674_+	thiaminase II	NA	NA	NA	NA
WP_002082716.1\|2527071_2527335_+	DUF3937 domain-containing protein	NA	NA	NA	NA
WP_001071366.1\|2527696_2528017_+\|bacteriocin	heterocycloanthracin/sonorensin family bacteriocin	NA	NA	NA	NA
WP_002041181.1\|2528510_2528996_+	hypothetical protein	NA	NA	NA	NA
WP_000736202.1\|2529307_2530009_+	DUF3962 domain-containing protein	NA	NA	NA	NA
WP_000675870.1\|2530047_2531157_-\|integrase	tyrosine-type recombinase/integrase	A0A0U3U8Y8	Bacillus_phage	2.9e-147	79.1
WP_001197707.1\|2531804_2533013_+	hypothetical protein	D2XQ10	Bacillus_virus	1.3e-81	45.4
WP_000791664.1\|2533039_2533195_+	hypothetical protein	NA	NA	NA	NA
WP_000425254.1\|2533455_2533806_-	helix-turn-helix transcriptional regulator	A0A288WFW4	Bacillus_phage	1.3e-16	38.8
WP_001180928.1\|2533989_2534286_+	helix-turn-helix transcriptional regulator	A0A288WG89	Bacillus_phage	1.1e-08	46.5
WP_000522024.1\|2534501_2534768_+	helix-turn-helix domain-containing protein	A0A0U3ULL9	Bacillus_phage	1.6e-35	90.6
WP_000390298.1\|2534767_2534932_+	hypothetical protein	A0A0U3B230	Bacillus_phage	1.5e-20	90.7
WP_001241130.1\|2534961_2535138_+	hypothetical protein	A0A0U3SQC4	Bacillus_phage	1.8e-24	91.4
WP_000190248.1\|2535142_2535889_+	DnaD domain protein	A0A1B0T6C0	Bacillus_phage	4.2e-78	79.9
WP_011110116.1\|2535827_2536703_+	ATP-binding protein	Q2I8C8	Bacillus_phage	8.5e-62	45.2
WP_000332463.1\|2536718_2536913_+	hypothetical protein	A0A1B1P7U7	Bacillus_phage	9.0e-25	87.5
WP_000805171.1\|2536938_2537112_+	DUF3954 domain-containing protein	A0A1B1P7U5	Bacillus_phage	1.8e-24	98.2
WP_000811858.1\|2537126_2537381_+	hypothetical protein	A0A0U3SU43	Bacillus_phage	8.8e-36	85.7
WP_000755581.1\|2537395_2537608_+	hypothetical protein	A0A1B0T6B5	Bacillus_phage	4.3e-20	79.0
WP_000343919.1\|2537789_2539400_-	collagen-like protein	NA	NA	NA	NA
WP_002196025.1\|2540132_2540837_-	collagen-like protein	NA	NA	NA	NA
2541349:2541367	attL	NA	NA	NA	NA
WP_001113469.1\|2542035_2542200_-	hypothetical protein	A0A288WGN0	Bacillus_phage	8.2e-19	96.3
WP_000183173.1\|2542327_2542450_+	DUF3983 domain-containing protein	NA	NA	NA	NA
WP_001013362.1\|2542470_2542659_+	hypothetical protein	NA	NA	NA	NA
WP_000677453.1\|2542757_2542928_+	hypothetical protein	A0A1B0T6D0	Bacillus_phage	1.0e-11	82.1
WP_000166181.1\|2542955_2543438_+	ArpU family transcriptional regulator	H0USV3	Bacillus_phage	1.1e-71	83.1
WP_001012145.1\|2543437_2543980_+\|integrase	site-specific integrase	W8CYP1	Bacillus_phage	5.0e-89	91.1
WP_000394432.1\|2544277_2544622_+	hypothetical protein	NA	NA	NA	NA
WP_000930971.1\|2544924_2545143_+	hypothetical protein	H0USV5	Bacillus_phage	3.1e-21	66.2
WP_011110117.1\|2545593_2545989_+	DUF3942 family protein	NA	NA	NA	NA
WP_001008298.1\|2546115_2546754_+	hypothetical protein	NA	NA	NA	NA
WP_000627242.1\|2546836_2547124_+	hypothetical protein	A0A1C8EAA0	Bacillus_phage	1.7e-43	90.5
WP_000872553.1\|2547120_2547513_+	HNH endonuclease	A0A1B1P7N1	Bacillus_phage	1.1e-72	96.2
WP_000113451.1\|2547597_2548023_+\|terminase	P27 family phage terminase small subunit	A0A1C8E969	Bacillus_phage	2.0e-69	95.0
WP_000587519.1\|2548019_2549744_+\|terminase	terminase large subunit	A0A1C8E985	Bacillus_phage	0.0e+00	93.4
WP_000573604.1\|2549810_2550317_+	hypothetical protein	NA	NA	NA	NA
WP_000524248.1\|2550333_2551518_+\|portal	phage portal protein	A0A1B1P7N5	Bacillus_phage	9.6e-218	97.0
WP_000687908.1\|2551507_2552089_+\|head,protease	HK97 family phage prohead protease	A0A1C8EA63	Bacillus_phage	2.7e-96	95.9
WP_001049345.1\|2552090_2553395_+\|capsid	phage major capsid protein	A0A1C8E976	Bacillus_phage	1.1e-193	93.0
WP_000369282.1\|2553396_2553657_+\|head,tail	phage head-tail connector protein	A0A1B2APX3	Phage_Wrath	9.3e-41	95.3
WP_001126093.1\|2553634_2553967_+	hypothetical protein	A0A1B2APX8	Phage_Wrath	1.3e-52	95.5
WP_001166632.1\|2553956_2554286_+	hypothetical protein	A0A1B0T6B7	Bacillus_phage	6.4e-55	95.4
WP_000157919.1\|2554285_2554663_+	HK97 gp10 family phage protein	A0A1C8E995	Bacillus_phage	1.8e-61	95.2
WP_000151368.1\|2554674_2555310_+	hypothetical protein	A0A1B1P7Q4	Bacillus_phage	1.9e-116	99.1
WP_000113343.1\|2555321_2555708_+	hypothetical protein	A0A1C8E984	Bacillus_phage	1.0e-64	97.7
WP_006927278.1\|2555746_2555935_+	hypothetical protein	A0A1C8E979	Bacillus_phage	8.2e-31	98.4
WP_001119328.1\|2555951_2559476_+\|tail	phage tail tape measure protein	A0A1B1P7P9	Bacillus_phage	0.0e+00	98.0
WP_000884118.1\|2559476_2560160_+\|tail	phage tail family protein	A0A1B0T6A0	Bacillus_phage	8.8e-123	94.2
WP_000439566.1\|2563849_2564275_+\|holin	phage holin family protein	A0A1B1P787	Bacillus_phage	1.0e-68	95.7
WP_000540622.1\|2564274_2565093_+	N-acetylmuramoyl-L-alanine amidase	D2XR33	Bacillus_phage	3.0e-146	87.9
WP_000644810.1\|2565231_2565984_-	hypothetical protein	NA	NA	NA	NA
WP_000626130.1\|2566495_2568178_+	DUF3893 domain-containing protein	NA	NA	NA	NA
WP_000732187.1\|2568384_2569149_+	DUF3959 family protein	NA	NA	NA	NA
WP_000905581.1\|2569291_2569708_+	DUF3995 domain-containing protein	NA	NA	NA	NA
WP_000878369.1\|2569828_2570032_+	hypothetical protein	NA	NA	NA	NA
WP_000362067.1\|2570360_2570573_-	hypothetical protein	NA	NA	NA	NA
WP_000565687.1\|2570782_2571787_+	DUF1835 domain-containing protein	NA	NA	NA	NA
WP_000282687.1\|2571932_2572337_+	hypothetical protein	NA	NA	NA	NA
WP_000062123.1\|2572496_2573732_+	cytochrome P450	NA	NA	NA	NA
WP_000106396.1\|2573999_2575283_+	MFS transporter	NA	NA	NA	NA
WP_001069204.1\|2575272_2575905_+	Vat family streptogramin A O-acetyltransferase	A0A2R8FE91	Brazilian_cedratvirus	1.6e-25	43.1
WP_000046095.1\|2575975_2576131_+	DUF1540 domain-containing protein	NA	NA	NA	NA
WP_000606465.1\|2576686_2577088_+\|transposase	IS200/IS605 family transposase	Q332K6	Clostridium_botulinum_C_phage	1.8e-51	72.0
WP_000084148.1\|2577093_2578173_+\|transposase	transposase	A0A1C9EG99	Acidianus_two-tailed_virus	5.1e-16	27.2
WP_000742122.1\|2578356_2578659_+	cytochrome P450	NA	NA	NA	NA
WP_000954442.1\|2578768_2579347_+	cysteine dioxygenase family protein	NA	NA	NA	NA
WP_000766394.1\|2579522_2580374_+	Cof-type HAD-IIB family hydrolase	NA	NA	NA	NA
WP_001088551.1\|2580825_2582613_+	PAS domain-containing protein	NA	NA	NA	NA
WP_000743777.1\|2582847_2584974_+	penicillin-binding protein 2	NA	NA	NA	NA
WP_000765190.1\|2585050_2585581_+	signal peptidase I	NA	NA	NA	NA
WP_000864400.1\|2587118_2587799_-	aspartate/glutamate racemase family protein	NA	NA	NA	NA
WP_000375121.1\|2588616_2589957_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_000205476.1\|2589953_2592323_+\|integrase	site-specific integrase	NA	NA	NA	NA
WP_002026795.1\|2592393_2594172_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_000439131.1\|2594150_2594717_+	hypothetical protein	NA	NA	NA	NA
WP_000615896.1\|2594763_2595714_-\|tRNA	methionyl-tRNA formyltransferase	NA	NA	NA	NA
2621518:2621536	attR	NA	NA	NA	NA

DBSCAN-SWA_7

3657053 : 3668825

Bacillus_phage(50.0%)

holin

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000413738.1\|3657053_3657674_+	transcriptional repressor LexA	A0A1B2APZ1	Phage_Wrath	8.2e-19	62.2
WP_000976237.1\|3657764_3658568_-	DUF4097 family beta strand repeat protein	NA	NA	NA	NA
WP_000031387.1\|3658568_3659111_-	DUF1700 domain-containing protein	NA	NA	NA	NA
WP_001102628.1\|3659103_3659427_-	PadR family transcriptional regulator	NA	NA	NA	NA
WP_000725954.1\|3660465_3661521_-	N-acetylmuramoyl-L-alanine amidase	A0A1B0T6C8	Bacillus_phage	9.0e-143	68.9
WP_000570187.1\|3661517_3661757_-\|holin	holin	A0A0A7AR38	Bacillus_phage	1.3e-25	78.7
WP_000348875.1\|3661756_3661993_-	hemolysin XhlA family protein	A0A2H4J382	uncultured_Caudovirales_phage	1.8e-14	87.2
WP_002026207.1\|3662070_3662277_-	hypothetical protein	NA	NA	NA	NA
WP_001051360.1\|3662625_3663447_-	M23 family metallopeptidase	A0A218KCJ1	Bacillus_phage	1.2e-20	38.6
WP_025921790.1\|3663796_3664774_-	lysozyme family protein	A0A223LKM8	Bacillus_phage	1.1e-33	43.9
WP_000464425.1\|3665012_3665399_-	DUF1492 domain-containing protein	A0A288WG73	Bacillus_phage	2.6e-47	71.4
WP_000883316.1\|3665373_3665511_-	hypothetical protein	NA	NA	NA	NA
WP_000511415.1\|3665517_3666390_-	DnaD domain protein	A0A2H4J394	uncultured_Caudovirales_phage	1.5e-95	65.0
WP_001189065.1\|3666542_3666737_-	hypothetical protein	A0A1C8E9A1	Bacillus_phage	1.7e-15	71.0
WP_000531223.1\|3666748_3667507_-	phage regulatory protein	A0A2H4JBC7	uncultured_Caudovirales_phage	7.0e-97	69.4
WP_000283431.1\|3667709_3667922_-	hypothetical protein	A6M975	Geobacillus_virus	1.6e-11	63.0
WP_011110319.1\|3668165_3668825_+	helix-turn-helix domain-containing protein	A0A2H4J441	uncultured_Caudovirales_phage	4.3e-34	41.0

DBSCAN-SWA_8

4352900 : 4426910

Klosneuvirus(25.0%)

integrase,protease,tRNA,coat

attL 4348339:4348356|attR 4410250:4410267

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
4348339:4348356	attL	NA	NA	NA	NA
WP_000125365.1\|4352900_4354040_-\|tRNA	tRNA guanosine(34) transglycosylase Tgt	A0A1B1IVQ4	uncultured_Mediterranean_phage	1.1e-82	42.3
WP_000354017.1\|4354052_4355105_-\|tRNA	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	NA	NA	NA	NA
WP_000138162.1\|4355124_4355325_-	DUF2905 domain-containing protein	NA	NA	NA	NA
WP_000464511.1\|4356328_4356946_-	Holliday junction DNA helicase RuvA	NA	NA	NA	NA
WP_000823606.1\|4357134_4358079_+	iron-hydroxamate ABC transporter substrate-binding protein	NA	NA	NA	NA
WP_000871192.1\|4358092_4358623_-	BofC C-terminal domain-containing protein	NA	NA	NA	NA
WP_000721223.1\|4359056_4359491_+	hypothetical protein	NA	NA	NA	NA
WP_001093536.1\|4359524_4360169_-	YhcN/YlaJ family sporulation lipoprotein	NA	NA	NA	NA
WP_000690750.1\|4360347_4362090_-\|coat	SafA/ExsA family spore coat assembly protein	NA	NA	NA	NA
WP_000025341.1\|4362315_4363422_-	quinolinate synthase NadA	NA	NA	NA	NA
WP_001092231.1\|4363451_4364285_-	carboxylating nicotinate-nucleotide diphosphorylase	NA	NA	NA	NA
WP_001138531.1\|4364304_4365834_-	L-aspartate oxidase	NA	NA	NA	NA
WP_000973777.1\|4365986_4367129_+	IscS subfamily cysteine desulfurase	A0A1X7QGF3	Faustovirus	5.0e-30	29.2
WP_000812275.1\|4367128_4367671_+	transcription repressor NadR	NA	NA	NA	NA
WP_000510673.1\|4367750_4368398_+	MOSC domain-containing protein	NA	NA	NA	NA
WP_000621705.1\|4368558_4369410_-	prephenate dehydratase	NA	NA	NA	NA
WP_001011413.1\|4371472_4373395_-	ABC transporter permease	NA	NA	NA	NA
WP_000114529.1\|4373369_4374146_-	ABC transporter ATP-binding protein	W5SAS9	Pithovirus	2.1e-19	31.0
WP_000865181.1\|4374239_4375322_-	HAMP domain-containing histidine kinase	NA	NA	NA	NA
WP_000276723.1\|4375311_4376019_-	response regulator transcription factor	NA	NA	NA	NA
WP_000497128.1\|4376158_4377445_-	GTPase ObgE	NA	NA	NA	NA
WP_001003584.1\|4377444_4377993_-	Spo0B domain-containing protein	NA	NA	NA	NA
WP_000944958.1\|4378056_4378347_-	50S ribosomal protein L27	NA	NA	NA	NA
WP_001973720.1\|4378350_4378695_-\|protease	ribosomal-processing cysteine protease Prp	NA	NA	NA	NA
WP_000270907.1\|4378706_4379015_-	50S ribosomal protein L21	NA	NA	NA	NA
WP_000855491.1\|4379184_4380573_-	Rne/Rng family ribonuclease	NA	NA	NA	NA
WP_000599058.1\|4380640_4381501_-\|protease	stage IV sporulation intramembrane metalloprotease SpoIVFB	NA	NA	NA	NA
WP_000797471.1\|4381493_4382240_-	stage IV sporulation protein SpoIVFA	NA	NA	NA	NA
WP_000503309.1\|4382373_4383171_-	septum site-determining protein MinD	NA	NA	NA	NA
WP_000391521.1\|4383173_4383860_-	septum site-determining protein MinC	NA	NA	NA	NA
WP_000975766.1\|4383895_4384441_-	rod shape-determining protein MreD	NA	NA	NA	NA
WP_001135485.1\|4384455_4385307_-	rod shape-determining protein MreC	NA	NA	NA	NA
WP_000466736.1\|4385348_4386368_-	rod shape-determining protein MreB	NA	NA	NA	NA
WP_001087647.1\|4386874_4388224_+	hypothetical protein	NA	NA	NA	NA
WP_164928351.1\|4388183_4391474_+	hypothetical protein	NA	NA	NA	NA
WP_001021385.1\|4391482_4393198_+\|integrase	tyrosine-type recombinase/integrase	NA	NA	NA	NA
WP_001037288.1\|4393190_4393889_+	hypothetical protein	NA	NA	NA	NA
WP_000700766.1\|4394893_4395580_-	hypothetical protein	NA	NA	NA	NA
WP_000537095.1\|4395989_4396610_-	TIR domain-containing protein	NA	NA	NA	NA
WP_000215932.1\|4396628_4398131_-	SIR2 family protein	NA	NA	NA	NA
WP_000794333.1\|4401391_4402636_-	restriction endonuclease subunit S	A0A2H4PQP5	Staphylococcus_phage	3.9e-20	31.0
WP_000762853.1\|4404241_4404808_-	restriction endonuclease subunit S	NA	NA	NA	NA
WP_001013395.1\|4405362_4405914_-	DNA repair protein RadC	NA	NA	NA	NA
WP_001226290.1\|4405960_4406536_-	septum formation inhibitor Maf	NA	NA	NA	NA
WP_000361009.1\|4406768_4407719_-	stage II sporulation protein B	NA	NA	NA	NA
WP_000582040.1\|4407884_4409186_-	bifunctional tetrahydrofolate synthase/dihydrofolate synthase	NA	NA	NA	NA
WP_000072244.1\|4409279_4411925_-\|tRNA	valine--tRNA ligase	A0A1V0SK04	Klosneuvirus	1.2e-164	42.8
4410250:4410267	attR	NA	NA	NA	NA
WP_000350658.1\|4412444_4413470_-\|coat	spore coat protein YsxE	NA	NA	NA	NA
WP_002195820.1\|4413536_4414547_-	stage VI sporulation protein D	NA	NA	NA	NA
WP_000712943.1\|4414626_4415916_-	glutamate-1-semialdehyde 2,1-aminomutase	A0A1V0SKB7	Klosneuvirus	1.7e-05	34.1
WP_001087065.1\|4415915_4416905_-	porphobilinogen synthase	NA	NA	NA	NA
WP_000992353.1\|4416925_4417678_-	uroporphyrinogen-III synthase	NA	NA	NA	NA
WP_001226407.1\|4417680_4418610_-	hydroxymethylbilane synthase	NA	NA	NA	NA
WP_000007721.1\|4418625_4419459_-	cytochrome c biogenesis protein CcsA	NA	NA	NA	NA
WP_000547841.1\|4419476_4420811_-\|tRNA	glutamyl-tRNA reductase	NA	NA	NA	NA
WP_000133916.1\|4421228_4421681_+	MarR family transcriptional regulator	NA	NA	NA	NA
WP_000359781.1\|4421683_4422100_+	organic hydroperoxide resistance protein	NA	NA	NA	NA
WP_000869116.1\|4422133_4422730_-	ribosome biogenesis GTP-binding protein YsxC	NA	NA	NA	NA
WP_000097289.1\|4422726_4425057_-	endopeptidase La	A0A0R6PGP8	Moraxella_phage	1.2e-176	43.5
WP_000119176.1\|4425239_4426910_-\|protease	ATP-dependent protease LonB	E3T4F6	Cafeteria_roenbergensis_virus	7.4e-14	33.0

DBSCAN-SWA_9

4481133 : 4488819

Staphylococcus_phage(16.67%)

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_000221070.1\|4481133_4482057_-	ABC transporter ATP-binding protein	A0A2H4PQG7	Staphylococcus_phage	1.4e-46	44.4
WP_000247675.1\|4482182_4483118_-	HAMP domain-containing histidine kinase	W8CYF6	Bacillus_phage	1.2e-21	24.7
WP_000018035.1\|4483119_4483812_-	response regulator transcription factor	B5LWA6	Feldmannia_species_virus	1.4e-06	28.8
WP_001293578.1\|4483980_4484154_+	hypothetical protein	NA	NA	NA	NA
WP_001014310.1\|4484154_4484349_+	YwbE family protein	NA	NA	NA	NA
WP_001235507.1\|4484387_4485587_-	class I SAM-dependent rRNA methyltransferase	W6LLI2	Streptococcus_phage	3.6e-71	41.2
WP_000587818.1\|4485882_4486206_+	heme oxygenase	NA	NA	NA	NA
WP_001086126.1\|4486278_4487043_-	class B sortase	NA	NA	NA	NA
WP_000403758.1\|4487075_4487846_-	ABC transporter ATP-binding protein	W6JKT0	Anomala_cuprea_entomopoxvirus	3.7e-13	27.1
WP_001036831.1\|4487835_4488819_-	iron ABC transporter permease	A0A2H4IY97	uncultured_Caudovirales_phage	2.5e-17	27.2

DBSCAN-SWA_10

5090739 : 5101174

Streptococcus_phage(25.0%)

transposase

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_001990088.1\|5090739_5090937_-	cold shock protein CspC	Q9AZD3	Lactococcus_phage	9.8e-19	67.7
WP_011110483.1\|5091063_5091768_-	ComF family protein	NA	NA	NA	NA
WP_000225360.1\|5091767_5093117_-	DEAD/DEAH box helicase	A0A1X9I5S6	Streptococcus_phage	8.5e-61	35.1
WP_000084148.1\|5093355_5094435_-\|transposase	transposase	A0A1C9EG99	Acidianus_two-tailed_virus	5.1e-16	27.2
WP_000606463.1\|5094440_5094842_-\|transposase	IS200/IS605-like element ISBce3 family transposase	Q332K6	Clostridium_botulinum_C_phage	1.4e-51	72.0
WP_000499481.1\|5095049_5096462_-	C40 family peptidase	A0A1V0DZX6	Clostridioides_phage	1.3e-11	39.8
WP_000400857.1\|5096610_5096925_-	helix-turn-helix transcriptional regulator	NA	NA	NA	NA
WP_000684725.1\|5097097_5097940_-	DegV family protein	A0A0N9SI50	Staphylococcus_phage	3.6e-17	40.3
WP_000926669.1\|5098176_5098812_+	YigZ family protein	A0A1X9I5T8	Streptococcus_phage	8.1e-38	40.6
WP_000392794.1\|5098894_5100019_+	LCP family protein	NA	NA	NA	NA
WP_000140145.1\|5100058_5101174_-	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	A0A1V0SAG5	Catovirus	1.0e-19	30.4

Anti-CRISPR protein detection

Acr ID	Acr position	Acr size	Homology with known anti	Neighbor HTH/AcRanker	Neighbor Aca	In prophage	Protospacer in prophage

Overview of predicted results

Overview of the results

Cas Category Instructions

Results visualization

1. NC_004721

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection

2. NC_004722

Click the left colored region to show detailed information

CRISPR-Cas detection and classification

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Click the colored protein region to show detailed information

Self-targeting detection

MGE targeting detection<

Prophage detection

Anti-CRISPR protein detection