CRISPRimmunity

Overview of predicted results

Overview of the results

Contig_ID	Contig_def	CRISPR array number	Contig Signature genes	Self targeting spacer number	Target MGE spacer number	Prophage number	Anti-CRISPR protein number
NC_005835	Thermus thermophilus HB27, complete sequence	2 crisprs	csa3,DEDDh,cas3,Cas9_archaeal,cas2,cas6	0	4	0	0
NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	9 crisprs	cas2,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,csx1,cmr3gr5,cmr1gr7,cmr4gr7,cmr5gr11,DinG,cas3,cas5,cas8c,cas7b,cas1,cas4,WYL,cas8b5,cas6	0	85	1	0

1. NC_005835

CRISPR-Cas detection and classification

Crispr_ID: NC_005835_1

• CRISPR_ID: NC_005835_1
• CRISPR_location: 541151-541341
• CRISPR_type: Orphan
• Repeat_type: III-A
• Spacer_info: 2 spacers

Consensus repeat of NC_005835_1

Consensus_repeat	Method
CATACGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	PILER-CR
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CRISPRCasFinder

spacers of NC_005835_1

>1.1|541192|36|NC_005835|PILER-CR
CTCTTTCAGGATCCACGCAAACTCCCTTCCTTGGGG
>1.2|541269|37|NC_005835|PILER-CR
GCCTCCACCATGGGGAGGAGGCCCTCCTCCCTCGCCA
>1.3|541188|40|NC_005835|CRISPRCasFinder
CTCTTTCAGGATCCACGCAAACTCCCTTCCTTGGGGCTTA
>1.4|541264|42|NC_005835|CRISPRCasFinder
GCCTCCACCATGGGGAGGAGGCCCTCCTCCCTCGCCACATAC

CRISPR arrays and Neighbor proteins around NC_005835_1

CRISPR arrays

The CRISPR arrays of NC_005835_1

>merge|NC_005835|1|541151-541341|PILER-CR,CRISPRCasFinder
CGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACCTCTTTCAGGATCCACGCAAACTCCCTTCCTTGGGGCTTAGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACGCCTCCACCATGGGGAGGAGGCCCTCCTCCCTCGCCACATACGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGTCGT

>NC_005835|1|1|541151-541337|PILER-CR
CGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACCTCT	TTCAGGATCCACGCAAACTCCCTTCCTTGGGGCTTA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACGCCTC	CACCATGGGGAGGAGGCCCTCCTCCCTCGCCACATAC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTG

>NC_005835|1|1|541152-541341|CRISPRCasFinder
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CTCTTTCAGGATCCACGCAAACTCCCTTCCTTGGGGCTTA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	GCCTCCACCATGGGGAGGAGGCCCTCCTCCCTCGCCACATAC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGTCGT

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005835.1|WP_011173008.1|548994_550206_-|potassium/proton-antiporter	unknown	unknown	gnl|CDD|235410
NC_005835.1|WP_011172997.1|536794_537193_+|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|223894
NC_005835.1|WP_041443406.1|550218_551493_-|glutamate-1-semialdehyde-2,1-aminomutase	unknown	unknown	gnl|CDD|234607
NC_005835.1|WP_011173007.1|547709_549011_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	unknown	unknown	gnl|CDD|235392
NC_005835.1|WP_011173002.1|543864_544476_+|dephospho-CoA-kinase	unknown	unknown	gnl|CDD|366476
NC_005835.1|WP_011172992.1|532890_533598_-|carbon-nitrogen-hydrolase-family-protein	unknown	unknown	gnl|CDD|143587
NC_005835.1|WP_041443401.1|533597_534203_-|biotin-transporter-BioY	unknown	unknown	gnl|CDD|224187
NC_005835.1|WP_024119826.1|545151_545667_+|RsmD-family-RNA-methyltransferase	unknown	unknown	gnl|CDD|367574
NC_005835.1|WP_041443404.1|546160_547651_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	unknown	unknown	gnl|CDD|234854
NC_005835.1|WP_011173003.1|544444_544948_-|glycerol-3-phosphate-acyltransferase	unknown	unknown	gnl|CDD|376884
NC_005835.1|WP_011172995.1|535310_536483_+|phosphoglycerate-kinase	unknown	unknown	gnl|CDD|234613
NC_005835.1|WP_011173000.1|541502_542615_-|AmmeMemoRadiSam-system-protein-B	unknown	unknown	gnl|CDD|280116
NC_005835.1|WP_081424908.1|542568_543864_-|HDIG-domain-containing-protein	unknown	unknown	gnl|CDD|131739
NC_005835.1|WP_011173005.1|545667_546150_+|pantetheine-phosphate-adenylyltransferase	unknown	unknown	gnl|CDD|234674
NC_005835.1|WP_011172996.1|536528_536816_+|ribosome-binding-factor-A	unknown	unknown	gnl|CDD|376719
NC_005835.1|WP_011172999.1|538448_540683_+|ribonuclease-R	unknown	unknown	gnl|CDD|273947
NC_005835.1|WP_148187558.1|540860_541100_-|hypothetical-protein	unknown	unknown	unknown
NC_005835.1|WP_011172998.1|537202_538447_+|aspartate-aminotransferase-family-protein	unknown	unknown	gnl|CDD|227325
NC_005835.1|WP_011172994.1|534314_535310_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase	unknown	unknown	gnl|CDD|223135
NC_005835.1|WP_011172991.1|532454_532889_-|SsrA-binding-protein-SmpB	unknown	unknown	gnl|CDD|235455

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005835.1|WP_011173008.1|548994_550206_-|potassium/proton-antiporter	gnl|CDD|235410	PRK05326, PRK05326, potassium/proton antiporter.	3.80571e-167
NC_005835.1|WP_081424908.1|542568_543864_-|HDIG-domain-containing-protein	gnl|CDD|131739	TIGR02692, putative_tRNA_nucleotidyltransferase, tRNA adenylyltransferase. The enzyme tRNA adenylyltransferase, also called tRNA-nucleotidyltransferase and CCA-adding enzyme, can add or repair the required CCA triplet at the 3'-end of tRNA molecules. Genes encoding tRNA include the CCA tail in some but not all bacteria, and this enzyme may be required for viability. Members of this family represent a distinct clade within the larger family pfam01743 (tRNA nucleotidyltransferase/poly(A) polymerase family protein). The example from Streptomyces coelicolor was shown to act as a CCA-adding enzyme and not as a poly(A) polymerase. [Protein synthesis, tRNA and rRNA base modification].	5.52357e-46
NC_005835.1|WP_011173007.1|547709_549011_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE	gnl|CDD|235392	PRK05291, trmE, tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE.	0
NC_005835.1|WP_011173002.1|543864_544476_+|dephospho-CoA-kinase	gnl|CDD|366476	pfam01121, CoaE, Dephospho-CoA kinase. This family catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form Coenzyme A EC:2.7.1.24. This enzyme uses ATP in its reaction.	2.68828e-81
NC_005835.1|WP_011172992.1|532890_533598_-|carbon-nitrogen-hydrolase-family-protein	gnl|CDD|143587	cd07197, nitrilase, Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes. This superfamily (also known as the C-N hydrolase superfamily) contains hydrolases that break carbon-nitrogen bonds; it includes nitrilases, cyanide dihydratases, aliphatic amidases, N-terminal amidases, beta-ureidopropionases, biotinidases, pantotheinase, N-carbamyl-D-amino acid amidohydrolases, the glutaminase domain of glutamine-dependent NAD+ synthetase, apolipoprotein N-acyltransferases, and N-carbamoylputrescine amidohydrolases, among others. These enzymes depend on a Glu-Lys-Cys catalytic triad, and work through a thiol acylenzyme intermediate. Members of this superfamily generally form homomeric complexes, the basic building block of which is a homodimer. These oligomers include dimers, tetramers, hexamers, octamers, tetradecamers, octadecamers, as well as variable length helical arrangements and homo-oligomeric spirals. These proteins have roles in vitamin and co-enzyme metabolism, in detoxifying small molecules, in the synthesis of signaling molecules, and in the post-translational modification of proteins. They are used industrially, as biocatalysts in the fine chemical and pharmaceutical industry, in cyanide remediation, and in the treatment of toxic effluent. This superfamily has been classified previously in the literature, based on global and structure-based sequence analysis, into thirteen different enzyme classes (referred to as 1-13). This hierarchy includes those thirteen classes and a few additional subfamilies. A putative distant relative, the plasmid-borne TraB family, has not been included in the hierarchy.	2.98482e-41
NC_005835.1|WP_041443401.1|533597_534203_-|biotin-transporter-BioY	gnl|CDD|224187	COG1268, BioY, Uncharacterized conserved protein [General function prediction only].	2.76434e-38
NC_005835.1|WP_024119826.1|545151_545667_+|RsmD-family-RNA-methyltransferase	gnl|CDD|367574	pfam03602, Cons_hypoth95, Conserved hypothetical protein 95.	7.13888e-38
NC_005835.1|WP_011172996.1|536528_536816_+|ribosome-binding-factor-A	gnl|CDD|376719	pfam02033, RBFA, Ribosome-binding factor A.	1.86681e-12
NC_005835.1|WP_041443406.1|550218_551493_-|glutamate-1-semialdehyde-2,1-aminomutase	gnl|CDD|234607	PRK00062, PRK00062, glutamate-1-semialdehyde 2,1-aminomutase.	0
NC_005835.1|WP_011173003.1|544444_544948_-|glycerol-3-phosphate-acyltransferase	gnl|CDD|376884	pfam02660, G3P_acyltransf, Glycerol-3-phosphate acyltransferase. This family of enzymes catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate to form lysophosphatidic acid.	2.12673e-10
NC_005835.1|WP_011172997.1|536794_537193_+|acyl-CoA-thioesterase	gnl|CDD|223894	COG0824, FcbC, Predicted thioesterase [General function prediction only].	4.167e-33
NC_005835.1|WP_011173000.1|541502_542615_-|AmmeMemoRadiSam-system-protein-B	gnl|CDD|280116	pfam01875, Memo, Memo-like protein. This family contains members from all branches of life. The molecular function of this protein is unknown, but Memo (mediator of ErbB2-driven cell motility) a human protein is included in this family. It has been suggested that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton.	2.49075e-89
NC_005835.1|WP_041443404.1|546160_547651_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase	gnl|CDD|234854	PRK00881, purH, bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional.	0
NC_005835.1|WP_011173005.1|545667_546150_+|pantetheine-phosphate-adenylyltransferase	gnl|CDD|234674	PRK00168, coaD, phosphopantetheine adenylyltransferase; Provisional.	6.3222e-102
NC_005835.1|WP_011172995.1|535310_536483_+|phosphoglycerate-kinase	gnl|CDD|234613	PRK00073, pgk, phosphoglycerate kinase; Provisional.	0
NC_005835.1|WP_011172999.1|538448_540683_+|ribonuclease-R	gnl|CDD|273947	TIGR02063, Ribonuclease_R, ribonuclease R. This family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans. [Transcription, Degradation of RNA].	0
NC_005835.1|WP_011172998.1|537202_538447_+|aspartate-aminotransferase-family-protein	gnl|CDD|227325	COG4992, ArgD, Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism].	0
NC_005835.1|WP_011172994.1|534314_535310_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase	gnl|CDD|223135	COG0057, GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism].	1.14746e-179
NC_005835.1|WP_011172991.1|532454_532889_-|SsrA-binding-protein-SmpB	gnl|CDD|235455	PRK05422, smpB, SsrA-binding protein SmpB.	2.14685e-74

Protein sequences

>NC_005835.1|WP_148187558.1|540860_541100_-|hypothetical-protein
MRKMKLGICTRRITGVFEGLHRWKATGERGDEKKKRIFAFHKGETGFQGPHPEVRVRGSIAHTATLGQVKISAKKGLPD
>NC_005835.1|WP_011172999.1|538448_540683_+|ribonuclease-R
MQETLLAFFKKTGRPHRLEEILHRFGLEKREAKAHLKALVERGLLEKKGSRYFLANRVQGPLSLHRDGYGFVRLPEGDLFIPPGYTQDAWPGDLVEARVMPPGRDGRPWGVVERVLKRARERLVGTLDFRKGRALLLPDEPNLPELPLAPEGLEGLKRGSRIVAQVHYGKRPYGTFLAYLGEGEAPETETEAVIAKYGLRAEFPEEVLKEAEAIPLEIPEAELRRREDFRGLRVFTIDGVDAKDFDDAIHVERLPRGYRIGVHIADVSHYVKEGSLLDQEAFLRGTSVYLPGRVLPMLPERLSNGVCSLRPGEDRLVLSVLVDLTEDLEVKRVRFREGVIRSVARLTYTEVEAFAEGFGLPEEHAFLAEDLRLLLDLTQRMREKRLKEGALDFGFPEVKVEVGEEGELHLIPQAEPKARSLIEELMLLANRLVAEYLVQKGLPGLFRVHEEPVQDAYEKLRQALARLGYTLPPKLSGHALQKALLASRGRPEEPVVAYLVLRSLRLARYAPENLGHFGLAMEHYLHFTSPIRRYPDLVVHRVLKAALRRTLTPARKARWQEAFPAIAEHASEMERKAEAAERELTKYYMAKWAELHVGERFLGKVTGVASFGAFVTLPNGVEGLVRLEALGPYTYSEEALALLGPKGRRIRLGDEMEVRIAGANPRLRQVDFLPVEEAPKKTENGKEKAKEVEMRKVVGPPKDRARDTRPERATVNTIYFGEWTPKEPEEPRPARTRARRKRRR
>NC_005835.1|WP_011172998.1|537202_538447_+|aspartate-aminotransferase-family-protein
MDLDAFTLFERHINPGLAGLLRFTGLDRVESHAEGPYVWDTQGKRYLDFLGLYGTLNLGHRHPKVVEAVKRQLDRMPMSVRVLVSEPTARLAAKLAEITPEGLEMVFFGNSGAEAVEAAIKLARAYTGKPGIVTTQGGFHGKTMGALSLTPKPEYQDPARPLLPGVKVVPYGDLKALEAAIDEDTAAVIVEPIQGEGGIRVPPEGYLRGVRELTREKGVLMIADEVQTGLGRTGRLFGVDWEGVAPDLMTLAKALGGGVMPIGACVGRREVFEVFKNNPLFHSSTFGGNPLAAAAALAAIEVTLEEDLPGRALELGRHLMEGLKALKEEHPHLIEDVRGRGLMVGVEFTDADIGALVVAEMAERGVLTAFGLNNPKVVRLEPPLIIGKEHVDEALAVFAEALKATEKALEGLLG
>NC_005835.1|WP_011172997.1|536794_537193_+|acyl-CoA-thioesterase
MESVTRIKVRYAETDQMGVVHHSVYAVYLEAARVDFLERAGLPYHRVEARGVFFPVVELGLTFRAPARFGEEVEVRTRLAELSSRALLFRYRVEREGVLLAEGFTRHLCQVGERAARIPEDIYRALSVLNLK
>NC_005835.1|WP_011172996.1|536528_536816_+|ribosome-binding-factor-A
MAYGKAHLEAQLKRALAEEIQALEDPRLFLLTVEAVRLSKDGSVLSVYVEAFREEEGALRALSRAERRLVAALARRVRMRRLPRLEFLPWRASPA
>NC_005835.1|WP_011172995.1|535310_536483_+|phosphoglycerate-kinase
MRTLLDLDPKGKRVLVRVDYNVPVQDGKVQDETRILESLPTLRHLLAGGASLVLLSHLGRPKGPDPRYSLAPVGEALRAHLPEARFAPFPPGSEEARREAEALRPGEVLLLENVRFEPGEEKNDPELSARYARLGEAFVLDAFGSAHRAHASVVGVARLLPAYAGFLMEKEVRALSRLLKDPERPYAVVLGGAKVSDKIGVIESLLPRIDRLLIGGAMAFTFLKALGGEVGKSLVEEDRLDLAKDLLGRAEALGVRVYLPEDVVAAERIEAGVETRVFPARAIPVPYMGLDIGPKTREAFARALEGARTVFWNGPMGVFEVPPFDEGTLAVGRAIAALEGAFTVVGGGDSVAAVNRLGLKDRFGHVSTGGGASLEFLEKGTLPGLEVLEG
>NC_005835.1|WP_011172994.1|534314_535310_+|type-I-glyceraldehyde-3-phosphate-dehydrogenase
MKVGINGFGRIGRQVFRILHERGVEVALINDLTDNKTLAHLLKYDSTYGRFPGAVGYDEENLYVDGKAIRATAIKDPREIPWKQAGVGVVVESTGVFTDGEKARAHLEAGAKKVIITAPAKNEDITVVLGVNHEQYDPAKHHIISNASCTTNSLAPVMKVLEEAFGVEKALMTTVHSYTNDQRLLDLPHKDLRRARAAALNIIPTTTGAAKATALVLPSLKGRFDGMALRVPTPTGSISDITALLKREVTAEEVNAALKAAAEGPLKGILAYTEDEIVLRDIVMDPHSSIVDGKLTKAIGNLVKVFAWYDNEWGYANRVADLVELVLKKGV
>NC_005835.1|WP_041443401.1|533597_534203_-|biotin-transporter-BioY
MKTEVLPYTPLMKTIWPQRTLSRDLLLILVGSLFVALTAQIALPLPFTPVPITGQTLGVLLVGAALGSRLGFLALLAYLLEGAMGLPVFAGGTGGIAKILGPTGGFLLAFPLAAGLVGLLVERFGLDRGFFGTLLAMLLGNALLYLVGLPWLAAWLMGAGKFGGVSALLAMGLFPFIPGDLVKAVLAALLFPTAWRFLGPR
>NC_005835.1|WP_011172992.1|532890_533598_-|carbon-nitrogen-hydrolase-family-protein
MRLALAHLAKRESLRELLQALRPLAQEARERGAGLLLLPELVLGKREDPGLSQALRELAEEAGLLLLAGHLAEGENRLQAFPQGPAYAKLHLYRAEGEEGDEGLRPGERPLLLPWEGRAFGLALCYDLDFPELFRAYALKGAQGFLVGAAWPGEYAGLLEVLARARAAENQAYLFLASRADTGSPSLFVAPDGRVLARREEEGLLVAEPDWGFLEAYRKKYPLLRHRREELYRLW
>NC_005835.1|WP_011172991.1|532454_532889_-|SsrA-binding-protein-SmpB
MAPVLENRRARHDYEILETYEAGIALKGTEVKSLRAGKVDFTGSFARFEDGELYLENLYIAPYEKGSYANVDPRRKRKLLLHKHELRRLLGKVEQKGLTLVPLKIYFNERGYAKVLLGLARGKKAYEKRREDKKEAVRRALEEL
>NC_005835.1|WP_011173000.1|541502_542615_-|AmmeMemoRadiSam-system-protein-B
MEGRLRLREPQITPIEGGFLVSDPYGVYEKPLALTEGGLFLLSLMEGRTLEEVQEEVFKRHGVLVPKKELEDLAKALEEAGLLLTEKVEARLKEEEEKLKRERPMRLAGLSYPEGEREARAFLEAFRASYPGEGEEARVLLMPHLEPSRVPEVYGAALAALEKTPPPERIYLVGVAHRPLKEKAAALPVPFQTPFGPALPDLPALQALDALLPFELFNTPLAFREEHSLELPLFFLKGRFPEARVLPLLVARRSPELGEALKVVLRDFPGLLVLAVDLSHVGPRFGDTPLTRTLAEEARRRDLGFLERLAEGEPEAALAFLGANPTRIDGVEVVASLLPLLRERKGKVLAHRLDLEAPTLSAVGAGTLVL
>NC_005835.1|WP_081424908.1|542568_543864_-|HDIG-domain-containing-protein
MDFPFYTPKDAFPVGGAVRDLLLGRRPTDLDYAALDPEKAAEEAKRRLGGSLFPLDPKRGHYRLVVGERTLDFTPLEGRLEEDLLRRDYRVNALLWKGGAVFGLKGVEEDLRRRLLVPVREENLYQDHLRSLRGVRLAATLGFGLPRRTREALGRHARFLQAHPEALPARERVKEELARLLLSPRAAFGLRLLERVGLLGVYLPELALLVGLHQGGVHHLPAWEHTLSAVFHLLWLWPEAPLEARLAALFHDVGKPLTRRFDPEVGRFRFLGHAEVGAEIARASLFWLRFPKEVVERVAGLVRRHMDRLPEERKALRRFFLRRQDLLPDLVYLMAADRLATRGVEREAWEVLGRYEEVLKDPLPQRPLLSGEEVMALLGLQEGPEVGRALKALLEAQAEGRVGTKEEARAFLLYWRGGREAQASGTPDHPH
>NC_005835.1|WP_011173002.1|543864_544476_+|dephospho-CoA-kinase
MGHEAKHPIIIGITGNIGSGKSTVAALLRSWGYPVLDLDALAARARENKEEELKRLFPEAVVGGRLDRRALARLVFSDPERLKALEAVVHPEVRRLLMEELSRLEAPLVFLEIPLLFEKGWEGRLHGTLLVAAPLEERVRRVMARSGLSREEVLARERAQMPEEEKRKRATWVLENTGSLEDLERALKAVLAELTGGAKGGRG
>NC_005835.1|WP_011173003.1|544444_544948_-|glycerol-3-phosphate-acyltransferase
MAAALLAGYLMGSLPFAFWFAALQGKAWSGREPLWRLGPVPAGLVLLLDFAKGVFAVALGEFLARDYTGGLAAGAAAAFAHALSPWLGLRRAGSLLAPLGVLFAVDPRLLLLAGLPAGVLLLAGRKAHPALLAFALALPLAALLLGGGQAHLLFALALSLALLWPPR
>NC_005835.1|WP_024119826.1|545151_545667_+|RsmD-family-RNA-methyltransferase
MVRILGGKARGVALKVPASARPSPVRLRKALFDYLRLRYPRRGRFLDLFAGSGAVGLEAASEGWEAVLVEKDPEAVRLLKENVRRTGLGARVVALPVEVFLPEAKAQGERFTVAFMAPPYAMDLAALFGELLASGLVEAGGLYVLQHPKDLYLPLGERRVYGENALTLVEV
>NC_005835.1|WP_011173005.1|545667_546150_+|pantetheine-phosphate-adenylyltransferase
MHVVYPGSFDPLTNGHLDVIQRASRLFEKVTVAVLENPSKRGQYLFSAEERLAIIREATAHLANVEAATFSGLLVDFVRRVGAQAIVKGLRAVSDYEYELQMAHLNRQLYPGLETLFILAATRYSFVSSTMVKEIARYGGDVSKLVPPATLRALKAKLGQ
>NC_005835.1|WP_041443404.1|546160_547651_+|bifunctional-phosphoribosylaminoimidazolecarboxamide-formyltransferase/IMP-cyclohydrolase
MWALLSVADKRGIVDFARGLAELGFRLLATGGTYRALREAGLPVTYISDFTGFPEILEGRVKTLHPKVHAALLARPDQEEELKALGLERIGVLAVNLYPFRETVARGASFAEALEQIDIGGPAMLRAAAKNHQAVLPVCDPEDYPRVLEALKAGPSPDFRQKLARKAFAHTALYDAAIAEWLSGEKFPEEKLLALRREASLRYGENPHQEAALYRVVGERGPLLEAQVLQGKAMSFNNYLDAEAAWNLVSEFAEPACVAVKHQNPCGVALGETPLEAYRKAYEADPVSIFGGIVAFNRPLDGPTAEALAEVFLEVVLAPSFSPEARAVLARKKNLRLLQVPFPAQGPYLDLRRLRGGVLLQDADTEDPAEPKVVTERAPTPEEWPDLRFAWKVVKHVRSNAIVVAKGGMTLGIGVGQTNRLAAARHALEAAGERAKGAVLASDAFFPFDDVVRLAASYGIAAIIQPGGSVRDQDSIRAAEEAGIAMVFTGVRHFRH
>NC_005835.1|WP_011173007.1|547709_549011_-|tRNA-uridine-5-carboxymethylaminomethyl(34)-synthesis-GTPase-MnmE
MRALRDPICAIATPLGKGAIGVVRLSGEGALEIAARVWRGKDPRRLKGGRFTLGEVVDPKTGEAIDQALLLVFRAPRSYTGEDLVEFQTHGSLAVLRRVMEVLVAEGARPAGRGEFTFRAYMNGKLDLAQAEAVLALIEAEGELARRQALRALEGALSRRIEALENRLLDLLAHIQALLDYPEEGVEPLEAERTLREVLAEVEALLAQAKASRLAQKGARLALIGAPNAGKSSLLNALLGYERALVSPIPGTTRDYLEAPLELFGIPLVAVDTAGVRETEDPVERMGVERALRIAEEADLVLYVVDRSQPKPAPPPLPWARTLKVATKSDLPPAWEDPEFLPVSSLTGEGLGRLKEALREALLGREGGEVLLTERQVEALLRARERLEEALALPEDLMGLALEEAARALALLTGKEVAEEVVARVFQNFCVGK
>NC_005835.1|WP_011173008.1|548994_550206_-|potassium/proton-antiporter
MAGAVADLFLFGASVLLLLSILLSRVSQRLGIPALLFFLALGMLAGSDGPGGIYFDDARLAQGLGVMALAFILFSGGLDTEWGKVRPVLLPGVVLATLGVALTALLVGFFASLILGFSPLQGLLLGAIVSSTDAAAVFSVLRSQGVRLKERLKALLELESGINDPMAILLTVGLTSLLLGAAQPKDLVWIGLKQLGLGLVLGYILGRGITWAWDQWGFQYRGLGLLLSFSLVLFSYGLTAVLGGSGFAAVYVAGLVVGQLSLRRKEELLLFHEGVAWIMQVLMFLVLGLLVFPSRLPEVAPKGALLALFLMFVARPLAAALCLFPFRWSWQEVLLVGWVGLRGAVPIVLATYPLLAGLPGAATLFNLVFFIVLFSVALQGPTLGFVARRLGLEEDKPADARPS
>NC_005835.1|WP_041443406.1|550218_551493_-|glutamate-1-semialdehyde-2,1-aminomutase
MERPISEAYFQEAKRHIPGGVSSPVRAFKAVGGTPPFLVRGEGAYVWDADGNRYLDYVMSWGPLILGHAHPKVLARVRETLERGLTFGAPSPLEVALAKKVKRAYPFVDLVRFVNSGTEATMSALRLARGYTNRPYIVKFRGNYHGHADGLLVEAGSGALTLGVPSSAGVPEEYAKLTLVLEYNDPEGLREVLRRRGEEIAAIIFEPVVGNAGVLVPTEDFLKALHEAREFGVLLIADEVMTGFRLAFGGATELLGLKPDLVTLGKVLGGGLPAAAYAGRREIMEKVAPLGPVYQAGTLSGNPLAMAAGLATLELLEENPGYYRYLEDLGARLERGLKEVLAQKGIPHAVNRVGSMVTVFFTEGPVVTFQDAKRTDTELFKRFFHGLLDRGIYWPPSNFEAAFLSVAHTEEDVEKTLEALGEAL

Crispr_ID: NC_005835_2

• CRISPR_ID: NC_005835_2
• CRISPR_location: 1136637-1137118
• CRISPR_type: Orphan
• Repeat_type: III-A
• Spacer_info: 6 spacers

Consensus repeat of NC_005835_2

Consensus_repeat	Method
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CRISPRCasFinder
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CRT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	PILER-CR

spacers of NC_005835_2

>2.1|1136673|37|NC_005835|CRISPRCasFinder,CRT
CGAGGAGGACGTGGCGGAGCTGGTGGAGCTTCTTGGG
>2.2|1136746|39|NC_005835|CRISPRCasFinder,CRT,PILER-CR
TGTGGGGTTTGAGGACACTCCCTATGGTCGTGTTCGCGT
>2.3|1136821|37|NC_005835|CRISPRCasFinder,CRT,PILER-CR
TGAACCTCTTCCGCGTCCTGCAGGACAGGGAGAGGTT
>2.4|1136894|47|NC_005835|CRISPRCasFinder,CRT,PILER-CR
AAGTGGCTGGAAGCGCTGAAACTCAGGGAGCTCGTAGAGGCAGTCCA
>2.5|1136977|35|NC_005835|CRISPRCasFinder,CRT,PILER-CR
TAAGCGACAGCCGCGTACTGGCCGCCTTCATCGGC
>2.6|1137048|35|NC_005835|CRISPRCasFinder,CRT,PILER-CR
GGAAGTGGACGGGTTGACTCGCACCGTCATCCTTG

CRISPR arrays and Neighbor proteins around NC_005835_2

CRISPR arrays

The CRISPR arrays of NC_005835_2

>merge|NC_005835|2|1136637-1137118|CRISPRCasFinder,CRT,PILER-CR
GTATCAATCCCCTTACGGGGCTCAATCCCTTGCAACCGAGGAGGACGTGGCGGAGCTGGTGGAGCTTCTTGGGGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACTGTGGGGTTTGAGGACACTCCCTATGGTCGTGTTCGCGTGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACTGAACCTCTTCCGCGTCCTGCAGGACAGGGAGAGGTTGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACAAGTGGCTGGAAGCGCTGAAACTCAGGGAGCTCGTAGAGGCAGTCCAGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACTAAGCGACAGCCGCGTACTGGCCGCCTTCATCGGCGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACGGAAGTGGACGGGTTGACTCGCACCGTCATCCTTGGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC

>NC_005835|2|2|1136637-1137118|CRISPRCasFinder
GTATCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CGAGGAGGACGTGGCGGAGCTGGTGGAGCTTCTTGGG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TGTGGGGTTTGAGGACACTCCCTATGGTCGTGTTCGCGT
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TGAACCTCTTCCGCGTCCTGCAGGACAGGGAGAGGTT
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	AAGTGGCTGGAAGCGCTGAAACTCAGGGAGCTCGTAGAGGCAGTCCA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TAAGCGACAGCCGCGTACTGGCCGCCTTCATCGGC
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	GGAAGTGGACGGGTTGACTCGCACCGTCATCCTTG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC

>NC_005835|2|1|1136637-1137118|CRT
GTATCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CGAGGAGGACGTGGCGGAGCTGGTGGAGCTTCTTGGG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TGTGGGGTTTGAGGACACTCCCTATGGTCGTGTTCGCGT
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TGAACCTCTTCCGCGTCCTGCAGGACAGGGAGAGGTT
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	AAGTGGCTGGAAGCGCTGAAACTCAGGGAGCTCGTAGAGGCAGTCCA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TAAGCGACAGCCGCGTACTGGCCGCCTTCATCGGC
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	GGAAGTGGACGGGTTGACTCGCACCGTCATCCTTG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC

>NC_005835|2|2|1136710-1137118|PILER-CR
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TGTGGGGTTTGAGGACACTCCCTATGGTCGTGTTCGCGT
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TGAACCTCTTCCGCGTCCTGCAGGACAGGGAGAGGTT
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	AAGTGGCTGGAAGCGCTGAAACTCAGGGAGCTCGTAGAGGCAGTCCA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TAAGCGACAGCCGCGTACTGGCCGCCTTCATCGGC
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	GGAAGTGGACGGGTTGACTCGCACCGTCATCCTTG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005835.1|WP_011173579.1|1133651_1135364_-|M3-family-oligoendopeptidase	unknown	unknown	gnl|CDD|274069
NC_005835.1|WP_011173576.1|1131480_1131969_-|DinB-family-protein	unknown	unknown	gnl|CDD|378981
NC_005835.1|WP_011173588.1|1145784_1146225_-|hypothetical-protein	unknown	unknown	unknown
NC_005835.1|WP_041443527.1|1147654_1148617_-|membrane-dipeptidase	unknown	unknown	gnl|CDD|238626
NC_005835.1|WP_011173591.1|1147267_1147681_+|PaaI-family-thioesterase	unknown	unknown	gnl|CDD|161843
NC_005835.1|WP_011173574.1|1130050_1131007_-|zinc-dependent-alcohol-dehydrogenase-family-protein	unknown	unknown	gnl|CDD|176233
NC_005835.1|WP_041443526.1|1146613_1147246_-|alpha/beta-hydrolase	unknown	unknown	gnl|CDD|223669
NC_005835.1|WP_011173585.1|1141899_1143486_-|IS200/IS605-family-accessory-protein-TnpB-related-protein	unknown	unknown	gnl|CDD|273793
NC_005835.1|WP_041443518.1|1126353_1127577_+|serine-hydroxymethyltransferase	unknown	unknown	gnl|CDD|234571
NC_005835.1|WP_011173587.1|1144119_1145643_+|tRNA-lysidine(34)-synthetase-TilS	unknown	unknown	gnl|CDD|238950
NC_005835.1|WP_011173580.1|1135671_1136625_+|IS110-family-transposase	unknown	unknown	gnl|CDD|376564
NC_005835.1|WP_011173589.1|1146221_1146617_-|hypothetical-protein	unknown	unknown	unknown
NC_005835.1|WP_011173575.1|1131068_1131464_-|DUF3197-domain-containing-protein	unknown	unknown	gnl|CDD|371529
NC_005835.1|WP_011173577.1|1131987_1132617_+|YkgJ-family-cysteine-cluster-protein	unknown	unknown	gnl|CDD|308985
NC_005835.1|WP_011173583.1|1139592_1141083_-|NADP-dependent-isocitrate-dehydrogenase	unknown	unknown	gnl|CDD|236416
NC_005835.1|WP_162467440.1|1137169_1137409_+|hypothetical-protein	unknown	unknown	unknown
NC_005835.1|WP_011173572.1|1127601_1129188_+|AAA-family-ATPase	unknown	unknown	gnl|CDD|223571
NC_005835.1|WP_011173573.1|1129199_1130060_+|hydroxymethylglutaryl-CoA-lyase	unknown	unknown	gnl|CDD|163676
NC_005835.1|WP_011173578.1|1132566_1133637_-|tRNA-pseudouridine(13)-synthase-TruD	unknown	unknown	gnl|CDD|211340
NC_005835.1|WP_011173582.1|1137729_1139529_+|RNB-domain-containing-ribonuclease	unknown	unknown	gnl|CDD|223631

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005835.1|WP_011173579.1|1133651_1135364_-|M3-family-oligoendopeptidase	gnl|CDD|274069	TIGR02290, oligoendopeptidase_F, oligoendopeptidase, pepF/M3 family. The M3 family of metallopeptidases contains several distinct clades. Oligoendopeptidase F as characterized in Lactococcus, the functionally equivalent oligoendopeptidase B of group B Streptococcus, and closely related sequences are described by TIGR00181. The present family is quite similar but forms a distinct clade, and a number of species have one member of each. A greater sequence difference separates members of TIGR02289, probable oligoendopeptidases of the M3 family that probably should not be designated PepF.	0
NC_005835.1|WP_011173576.1|1131480_1131969_-|DinB-family-protein	gnl|CDD|378981	pfam12867, DinB_2, DinB superfamily. The DinB family are an uncharacterized family of potential enzymes. The structure of these proteins is composed of a four helix bundle.	4.177e-08
NC_005835.1|WP_041443527.1|1147654_1148617_-|membrane-dipeptidase	gnl|CDD|238626	cd01301, rDP_like, renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. Although the biological function of the enzyme is still unknown, it has been suggested to play a role in the renal glutathione metabolism.	1.11548e-54
NC_005835.1|WP_011173591.1|1147267_1147681_+|PaaI-family-thioesterase	gnl|CDD|161843	TIGR00369, Putative_esterase, uncharacterized domain 1. Most proteins containing this domain consist almost entirely of a single copy of this domain. A protein from C. elegans consists of two tandem copies of the domain. The domain is also found as the N-terminal region of an apparent initiation factor eIF-2B alpha subunit of Aquifex aeolicus. The function of the domain is unknown.	1.8472e-37
NC_005835.1|WP_011173574.1|1130050_1131007_-|zinc-dependent-alcohol-dehydrogenase-family-protein	gnl|CDD|176233	cd08272, MDR6, Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family. This group is a member of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, but lacks the zinc-binding sites of the zinc-dependent alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P)-binding Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability. ADH-like proteins typically form dimers (typically higher plants, mammals) or tetramers (yeast, bacteria), and generally have 2 tightly bound zinc atoms per subunit. The active site zinc is coordinated by a histidine, two cysteines, and a water molecule. The second zinc seems to play a structural role, affects subunit interactions, and is typically coordinated by 4 cysteines.	4.83385e-142
NC_005835.1|WP_041443526.1|1146613_1147246_-|alpha/beta-hydrolase	gnl|CDD|223669	COG0596, MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only].	1.43587e-05
NC_005835.1|WP_011173585.1|1141899_1143486_-|IS200/IS605-family-accessory-protein-TnpB-related-protein	gnl|CDD|273793	TIGR01766, Putative_transposase_MJ0751, transposase, IS605 OrfB family, central region. This model represents a region of a sequence similarity between a family of putative transposases of Thermoanaerobacter tengcongensis, smaller related proteins from Bacillus anthracis, putative transposes described by pfam01385, and other proteins. [Mobile and extrachromosomal element functions, Transposon functions].	1.14582e-10
NC_005835.1|WP_041443518.1|1126353_1127577_+|serine-hydroxymethyltransferase	gnl|CDD|234571	PRK00011, glyA, serine hydroxymethyltransferase; Reviewed.	0
NC_005835.1|WP_011173587.1|1144119_1145643_+|tRNA-lysidine(34)-synthetase-TilS	gnl|CDD|238950	cd01992, PP-ATPase, N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This domain has a strongly conserved motif SGGXD at the N terminus.	5.04436e-65
NC_005835.1|WP_011173580.1|1135671_1136625_+|IS110-family-transposase	gnl|CDD|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	2.18932e-28
NC_005835.1|WP_011173575.1|1131068_1131464_-|DUF3197-domain-containing-protein	gnl|CDD|371529	pfam11432, DUF3197, Protein of unknown function (DUF3197). This bacterial family of proteins has no known function.	3.58369e-51
NC_005835.1|WP_011173577.1|1131987_1132617_+|YkgJ-family-cysteine-cluster-protein	gnl|CDD|308985	pfam03692, CxxCxxCC, Putative zinc- or iron-chelating domain. This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex. However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.	0.00349708
NC_005835.1|WP_011173583.1|1139592_1141083_-|NADP-dependent-isocitrate-dehydrogenase	gnl|CDD|236416	PRK09222, PRK09222, NADP-dependent isocitrate dehydrogenase.	0
NC_005835.1|WP_011173572.1|1127601_1129188_+|AAA-family-ATPase	gnl|CDD|223571	COG0497, RecN, ATPase involved in DNA repair [DNA replication, recombination, and repair].	3.34345e-145
NC_005835.1|WP_011173573.1|1129199_1130060_+|hydroxymethylglutaryl-CoA-lyase	gnl|CDD|163676	cd07938, DRE_TIM_HMGL, 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain. 3-hydroxy-3-methylglutaryl-CoA lyase (HMGL) catalyzes the cleavage of HMG-CoA to acetyl-CoA and acetoacetate, one of the terminal steps in ketone body generation and leucine degradation, and is a key enzyme in the pathway that supplies metabolic fuel to extrahepatic tissues. Mutations in HMGL cause a human autosomal recessive disorder called primary metabolic aciduria that affects ketogenesis and leucine catabolism and can be fatal due to an inability to tolerate hypoglycemia. HMGL has a TIM barrel domain with a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. The cleavage of HMG-CoA requires the presence of a divalent cation like Mg2+ or Mn2+, and the reaction is thought to involve general acid/base catalysis. This family belongs to the DRE-TIM metallolyase superfamily. DRE-TIM metallolyases include 2-isopropylmalate synthase (IPMS), alpha-isopropylmalate synthase (LeuA), 3-hydroxy-3-methylglutaryl-CoA lyase, homocitrate synthase, citramalate synthase, 4-hydroxy-2-oxovalerate aldolase, re-citrate synthase, transcarboxylase 5S, pyruvate carboxylase, AksA, and FrbC. These members all share a conserved triose-phosphate isomerase (TIM) barrel domain consisting of a core beta(8)-alpha(8) motif with the eight parallel beta strands forming an enclosed barrel surrounded by eight alpha helices. The domain has a catalytic center containing a divalent cation-binding site formed by a cluster of invariant residues that cap the core of the barrel. In addition, the catalytic site includes three invariant residues - an aspartate (D), an arginine (R), and a glutamate (E) - which is the basis for the domain name "DRE-TIM".	1.4951e-117
NC_005835.1|WP_011173578.1|1132566_1133637_-|tRNA-pseudouridine(13)-synthase-TruD	gnl|CDD|211340	cd02575, PseudoU_synth_EcTruD, Pseudouridine synthase, similar to Escherichia coli TruD. This group consists of bacterial pseudouridine synthases similar to Escherichia coli TruD. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). E. coli TruD makes the highly phylogenetically conserved psi13 in tRNAs.	1.70221e-101
NC_005835.1|WP_011173582.1|1137729_1139529_+|RNB-domain-containing-ribonuclease	gnl|CDD|223631	COG0557, VacB, Exoribonuclease R [Transcription].	8.23357e-72

Protein sequences

>NC_005835.1|WP_011173580.1|1135671_1136625_+|IS110-family-transposase
MTFAGIDVSKPHLDLALVSNSPKPTRLRFPNTPEGRKALLAALAHLRPAWVALEPTGAYHLPLLKLLAENRLQVALVNPYHLAAFRKAKGERQKTDRHDALLLARYAQVYHGELRAYTLPPEALRELKALVGYREDLAGRERAILNQMEAVEWAGSGEVLALLQKELACVKGLLGEVEARIQALLATLPEAEALMALPGVGPQVAAAVLALLPPELWGRAKRAASYAGLTPEREESGKRVERSRLSKKGPPLLRRKLYMGALVAVRHDPEMRAFYHRLLSRGKRKKQALVAVAHKLLRRMMGRLREYYATQLDQGVA
>NC_005835.1|WP_011173579.1|1133651_1135364_-|M3-family-oligoendopeptidase
MEWNLDDLYAGPADPRIEEDLKAALALAQGLDPQGLLDPKGAQDLLGRYEKALELAYKPLNYASLYFATRTQDPEAKTLLDRVRSRFTEVRNRLVPLEVALRKLPEEAFQRLLAHPGLADLGHFLKRQRAYAPHTLSEREEELLNLKALVGRSAWSQFYTEYTGRFRFRVGERELTEMEVRALRRDPDPEVRREAHRALYGKLLAEAPTLSAVFNAVYLDYLQDLRLRGYRHPLEPVALRDEVEVREIEALLEATKAHYPLVERYYRWKAGRLGREKTPSEDLLAPLGEKPKVPFAEAQALVLEAFRRFSPELAEIAREFFEKRWIDVYPRPGKRGGAFCSGGLPSTHPYILLNHTDDLDSAHTLAHELGHGVHFYLARKQRLLNFGASTPLAETASVFAEILLDDLLLERLSGEEKTLLLAERVEDAINTLFRQVMYTFFEQRSLEARKEAALSPEAFHALWDEEQRRLYGEAVAWTELDRAAWAGIPHFVHYRFYTYSYALGYLVVLALYGKYREEGEAFVPKYLRILEAGESASPKEILAEAGVELGSEAFFRYGFGVLESWLKALP
>NC_005835.1|WP_011173578.1|1132566_1133637_-|tRNA-pseudouridine(13)-synthase-TruD
MDLVFRPERYPFLTQDLPGVGGEIRVEPEDFQVEEVPAYLPKGEGEHLYFLLEKEGRTTREVLEFLRDEVGVPEKEIGVAGLKDKRAKTRQWFSIPRKYEDALCLLENLQGVRLLAADLHTNKLRTGHLKGNRFHILIRRPKGGVAEAEAVLKRLAEKGVPNYYGPQRFGLGGLNPVRGYKLVKEGKGRGSPWLKRFLIGSLQSLLFNDWVALRMALGLYDRVVLGDWAKKHATGGEFLVEDPGEAERALRLEISATGPLFGKKYPEAQGEARAIEDEVLARYGLKREEFRARRGARRPIRVPLAEWKVEEAPEGLWLSFFLPKGSYATSLLREVMKVEALDHLEAEPAPEDAEGL
>NC_005835.1|WP_011173577.1|1131987_1132617_+|YkgJ-family-cysteine-cluster-protein
MEAVERAFRALDEGIADYLARKGIRPSCGPGCFACCYGWVTASRLEAQALLPHLTEAQKARVLEEGPRRLALLAREKDDPGFPRRFFLSRSPCPLLEAGLCGVYAHRPLACRGVLTDEDPAYCDPENPHPAPKPHHGPGHFLRVPHRMARRRMEELWEEERAQTGFLVLGELSGLLYLLLTGLPEDREGVEARLEALGVLGGRFGFQVV
>NC_005835.1|WP_011173576.1|1131480_1131969_-|DinB-family-protein
MPAPFLEPLEPGVSPAVSAWIKGLKEVALHLDKWAFDLPEEPFWRRPKEGANPIGGLVRHIAGSSLRLAHYALGVELPEWARKGREWELLGAPEPKEAVEARFREAWEVLLAAFRRVEEAALAEVVRVGHLGAEAPRAHVLHHLVEHAQHHAGQVIYARKLL
>NC_005835.1|WP_011173575.1|1131068_1131464_-|DUF3197-domain-containing-protein
MVRVGMRAAPRVSLEALKAALGGLKLSEAKVYLITDWQDKRDQARYALLLHTGKKDLLVPDAFGPAFPGGEEALSELVGLLLAQGARRFYEAVVSPGEMTALLDLPPEELLKRVMAIANPTDPGIYLKRAA
>NC_005835.1|WP_011173574.1|1130050_1131007_-|zinc-dependent-alcohol-dehydrogenase-family-protein
MRAVVLKGFGGLEMLEERDLPVPEPGPGEVLVRNLAVAVNPVDAKIRAAGRWAGVEPPFVLGYDAAGVVAKVGPGVKDLKEGDEVYYTPEIFGNPHGTYAEYTPVPAGIVAKKPKNLSFAEAAAIPLAGGTAWEAVVRRLAVRPGETVLVMGGAGGVGSFAVQFAKAAGAYVIATASAENLPVLKELGADLTLDYRGPWAEEVLKATEGQGVDAAFETAGESLVERVIPVVRPFGRIATILPPQGNLSGLYTKNQTLYGVFLTRERKRLLEMRPLFERGLARPLIAEVLPFSLENLRKAHARMDSGHGRGKIVLTFQA
>NC_005835.1|WP_011173573.1|1129199_1130060_+|hydroxymethylglutaryl-CoA-lyase
MKASVRWVECPRDAWQGFSRFIPTEEKVAFLNELLEAGFAHLDLTSFVSPKWVPQMQDAEEVLKALPPPNGRTYLAIVANEKGLERALAAPNLTHVGYPFSLSETFQQRNTNRSIEASWPLVGAMVERTEGRLGLVVYLSMAFGNPYGDPWSVEAVLEALARLKEMGVREIALADTYGVAEPERIHEVLKAAVARFGPEGLGAHLHARPEGALAKVEAVLAAGVTWLEGALAGVGGCPFAGDELVGNLPTEVVLPHLEKRGLATGVDLSRLPLLAEEAARLKALYA
>NC_005835.1|WP_011173572.1|1127601_1129188_+|AAA-family-ATPase
MGGMLRRLEVQNLAVIREAALDFAPGLNVLTGETGAGKSLLVDALALLLGGRAEGLIGPYGESLLVTAFFEGPPGEAVLSRRVGARSTPRVDGEVVTLKELQAEAERRLSLHAQHTALALLSPRRQREALDALLPEGLLAAYQEAYARREALLKEKAALEESLKARAEREDLLRYQIREIEEARVRPGEEEELLALAERLRHLETIRERLARALALLTEREAQDLLALAAKEVRAAARHDPALEALAEELSGAAEAVRAVARELEDHLEGLDLDPEELDRVEARLSLLERLKRKYGPTLADVLAHAQKAREELARMEGGEERLSEVERLLKALHEEVEARGQALRRAREEAARRLTEGMVRELPALGLAGARFAVVLEPLPEPGPQGLEAVAFRVAPNPNLPPAPLEALSGGELSRVALALALLTGTEAPTVVFDEVDAGVGGETAWRLAERLKRLAERRQVLVVTHLPQVAAVAQRHFRVTKTPEGVRVEPLAGEARVQEIARLLSGAYTQAALAHARELLEAQGAL
>NC_005835.1|WP_041443518.1|1126353_1127577_+|serine-hydroxymethyltransferase
MVSTLKRDEALFELIALEEKRQREGLELIASENFVSKQVREAVGSVLTNKYAEGYPGARYYGGCEAIDRVESLAIERAKALFGAAWANVQPHSGSQANMAVYMALMEPGDTLMGMDLAAGGHLTHGSRVNFSGKLYKVVSYGVRPDTELIDLEEVRRLALEHRPKVIVAGASAYPRFWDFKAFREIADEVGAYLVVDMAHFAGLVAAGLHPNPLPYAHVVTSTTHKTLRGPRGGLILSNDPELGKRIDKLIFPGIQGGPLEHVIAGKAVAFFEALQPEFKEYSRLVVENAKRLAEALARRGYRIVTGGTDNHLFLVDLRPKGLTGKEAEERLDAVGITVNKNAIPFDPKPPRVTSGIRIGTPAITTRGFTPEEMPLVAELIDRALLEGPSEALREEVRRLALAHPMP
>NC_005835.1|WP_162467440.1|1137169_1137409_+|hypothetical-protein
MRKMKLGICTRRITGVFEGLHRWKATGERGDEKKKRIFAFRKGKNGFQDPHPEVRVGKSIAHTATLHQVKISAKKRLPK
>NC_005835.1|WP_011173582.1|1137729_1139529_+|RNB-domain-containing-ribonuclease
MLRGVAALVVYKGKPALAEEKGGRLELTLEGGARQRVRPKDVLFLHPGPASLDLKVPEGEEEAAWELLEGQTVSLRELAELVYGAYTPEAALGAYLLAQKGERFVLEGEGVRARTREELLALQEAERKRAERERAFQEALKRLKEGSPAPEDRPLLAEVEALARGERKESPVLRALNLPETPEAAHAFLLRLGLWQRENPHPRRLGLPLQPPDLPVPPLPEEDRVDLTHLPAFAIDDEGSQDPDDAVFAEKVEGGFRLFVHVADVAALVPPKSPLDEEALRRGANLYLPEGTVPMLPPAVTEALGLGLREVSPALTFELWVSEEGELLEERVYPSWVRVTRLTYREALGVEALRPLEALAEAFRAKRLAAGALEIALPEVKVRVEGEEVRITPLPPYPSRVWVREAMLLAGYAAAHLAVREGLPFPFATQEAPARRVEGEGLAAMWEQRKALKRAQLKAVPAPHKGLGLPLYAQVTSPLRRYLDLVAHQQLRAWLKGERPLSQAEVLERVGAAEAVADLVREAERKSKLHWTLLHLEAKGYEGPGVLVERRGGQGVFLLPELGLTAQVALPKALPLNAEARLRFLEADLPALEARFALV
>NC_005835.1|WP_011173583.1|1139592_1141083_-|NADP-dependent-isocitrate-dehydrogenase
MPLITTETGKKMHVLEDGRKLITVIPGDGVGPECVEATLKVLEAAKAPLAYEVREAGASVFRRGIASGVPQETIESIRKTRVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGIDLVVVRENVEDLYAGIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMNGDILSDLTSGLIGGLGFAPSANIGNEVAIFEAVHGSAPKYAGKNVINPTAVLLSAVMMLRYLEEFATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGKTPRKTQVRGYKPFRLPQVDGAIAPIVPRSRRVVGVDVFVETNLLPEALGKALEDLAAGTPFRLKMISNRGTQVYPPTGGLTDLVDHYRCRFLYTGEGEAKDPEILDLVSRVASRFRWMHLEKLQEFDGEPGFTKAQGED
>NC_005835.1|WP_011173585.1|1141899_1143486_-|IS200/IS605-family-accessory-protein-TnpB-related-protein
MKAKPKATRKRTSQKRAKAFTGAHALLVFPSGEDHKATLDLMRRFSAAVRYAYNRLLEGWSREALKRENGPLRIFFGLNTRYADDAVMKAQALLDSAQERGEDPRKVVFGGRRLFETLKRGHLSGKPLKELKREWKEKRQGLLYSRGDKTKGGNLNLRLFVKDGALWLRINLGDGGYAHALIQTKHPNLSTLLQRAYASLPYNVELSLKDGKVYATFTWEEEPAPLVATKENGVLALDVNSDPYHLALALVSPDGNLRRHLTLSLEEVDRAPNKGAKELVLWKIAHEVVSLALEHGVAVATERLRYLRKSRRGDGSGRAFRRKQHRFAYASLLRKVHSLAGKRGVQVVEVNPQDTSTIGMLKYAPQLSLSKDVAAAYVIGRRALGFAEKLPRGYGRLLRDKTFLAQAQEFYQARVRELHAQKKAEHDRSRRNRLSRELKRAHGALSLLSSLQGSSGSQREVTDGRNSPGVNPWRVLRVGTFLPLLGREVPRDLSPLKPILFGGSWEGWRGGLGPHPGGGPECANVRST
>NC_005835.1|WP_011173587.1|1144119_1145643_+|tRNA-lysidine(34)-synthetase-TilS
MDVPAFRERLLRLAPKDPLVLAVSGGGDSVALALLVKEAGRQAVVAHLDHGLRPESPLDQAFVRALAERLGFPFFTERVEVARIAQARGENLEAVAREVRYAFLHRVAREVGARAILTAHTLDDQAETVLLQLLQGTARATGIREREGIVVRPLLAHTREELRAYLRARGEAWREDPTNQDPALDRNFLRLFVFPLLEERFPAAKRALARFAEARAEEEGVLERQAEARLLPDPRFFVPAFRAAPLLEAPLAVRRRALRRLLEKLGLRPEARLVLLLEEALRGRPQTLPGGVLARRKGGTLFLLPPRPRLPLPPGFRRPAPGDYLERPSGRKRLVDFLAEKGVPRELKPLWPVRAEGSRVVEVLGLYPPPPEEAHMAEALAEAASAFREGEVPVGAVLVLPGRVLRAHNRVEGLRDPTAHAEMLLLREAGPEARGGRLYVTLEPCLMCHHALAQAGVEVVYGAENLKEGALTRFGLPTRARGGVRERECAKLLRDFFARLREGCRSG
>NC_005835.1|WP_011173588.1|1145784_1146225_-|hypothetical-protein
MRKLLATAVLLLGLASAQFSVENLKPSFALVGGTQGFGGELSWHCLLFQPPVGEVRPALDLAYDVNGNLNGAFLFRYLYPVAEGLKAGVGLGVALPGFSFANLGLYFRADAEYDLAQFLNAPAFVGADLGLAGGTLAAQFKVGYRF
>NC_005835.1|WP_011173589.1|1146221_1146617_-|hypothetical-protein
MRRAGYLHLYGLNLVFDRVGKGPPVLLVAEEASRWPEALPEGYAFYLLDLPGYGRTEGPRMAPEELAHFVAGFVVMMNLGAPWVLLRGLGLALGPHLEALGLRALPAEGVEVAAVLSSKLSYGNIDLGGNL
>NC_005835.1|WP_041443526.1|1146613_1147246_-|alpha/beta-hydrolase
MGEIRLFPGLLAPPAGLDFLLDLPSEEGLHLVAFAEGALDALKVAFQEGARSLVLLSPVLFRDALLSARLGALRFGLERGGVEGFARVGRALFFGALSAGSEEVYEAWKEGLSEAGLWRWLGRLEALADERRWLRGTAARVLVVQGALDAFTPPLHGAKVADFAKGEALRFVVDEAGHLVPWEAQEEVRDLVADFLLGEGFRPLPGGLAL
>NC_005835.1|WP_011173591.1|1147267_1147681_+|PaaI-family-thioesterase
MEVKAFLERETLDRTLGVRYLKAEKDEVVAELMVTPKVHQPFGFLHGGATVALAESVASVGGFLNCPPGHAAFGLEINCNHLRKKREGTIRAVGRPLHVGRTTQVWEVKVYDEEGRLVAASRCTLAVVPLEPAKEPA
>NC_005835.1|WP_041443527.1|1147654_1148617_-|membrane-dipeptidase
MPRFLVDAHLDLAWNARALGRDLTLPLEALRAQDPHPDTPLVTLPSLKEAGVALAFATLFVDPREGAQEDWEEEVYAQLALYEAWERRGLVRVLREREDLLAHLERFPQDGVLGLVLLLEGAHALEAPEDLRPLRKRGLRLLSLTWATGNAYAGGNAEPGPLTAKGRALLEAMAALGVALDLSHLAEEAAWEALRVYEGPVCATHANCRALVPSERHLSDGLLRALAGREGVLGLVPFNAFLDPAWKRGMARLPLEAFFRHKAHAEALMGGGRVGLGTDWDGGFGLEAVPQGLDRHRDLRALGDEGFLGGNWLRWLLGWF

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_005835_1	1.1|541192|36|NC_005835|PILER-CR	541192-541227	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	213299-213334	0	1.0
NC_005835_1	1.3|541188|40|NC_005835|CRISPRCasFinder	541188-541227	40	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	213295-213334	0	1.0
NC_005835_2	2.1|1136673|37|NC_005835|CRISPRCasFinder,CRT	1136673-1136709	37	NZ_CP012916	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence	508803-508839	9	0.757
NC_005835_2	2.1|1136673|37|NC_005835|CRISPRCasFinder,CRT	1136673-1136709	37	NZ_CP032341	Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence	539798-539834	9	0.757
NC_005835_1	1.2|541269|37|NC_005835|PILER-CR	541269-541305	37	NC_017273	Thermus thermophilus SG0.5JP17-16 plasmid pTHTHE1601, complete sequence	349816-349852	10	0.73
NC_005835_1	1.2|541269|37|NC_005835|PILER-CR	541269-541305	37	NC_017588	Thermus thermophilus JL-18 plasmid pTTJL1801, complete sequence	148845-148881	10	0.73
NC_005835_2	2.1|1136673|37|NC_005835|CRISPRCasFinder,CRT	1136673-1136709	37	NZ_CP022363	Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence	147942-147978	10	0.73
NC_005835_2	2.1|1136673|37|NC_005835|CRISPRCasFinder,CRT	1136673-1136709	37	NZ_CP032347	Azospirillum brasilense strain MTCC4039 plasmid p2, complete sequence	435105-435141	10	0.73
NC_005835_1	1.2|541269|37|NC_005835|PILER-CR	541269-541305	37	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	28693-28729	16	0.568
NC_005835_1	1.2|541269|37|NC_005835|PILER-CR	541269-541305	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	225404-225440	16	0.568
NC_005835_1	1.2|541269|37|NC_005835|PILER-CR	541269-541305	37	NZ_AP019802	Thermus thermophilus strain HC11 plasmid pHC11, complete sequence	153953-153989	16	0.568
NC_005835_1	1.2|541269|37|NC_005835|PILER-CR	541269-541305	37	NZ_LR027520	Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence	234894-234930	16	0.568

1. spacer 1.1|541192|36|NC_005835|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ctctttcaggatccacgcaaactcccttccttgggg	CRISPR spacer
ctctttcaggatccacgcaaactcccttccttgggg	Protospacer
************************************

2. spacer 1.3|541188|40|NC_005835|CRISPRCasFinder matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ctctttcaggatccacgcaaactcccttccttggggctta	CRISPR spacer
ctctttcaggatccacgcaaactcccttccttggggctta	Protospacer
****************************************

3. spacer 2.1|1136673|37|NC_005835|CRISPRCasFinder,CRT matches to NZ_CP012916 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p2, complete sequence) position: , mismatch: 9, identity: 0.757

cgaggaggacgtggcggagctggtggagcttcttggg------	CRISPR spacer
caaggaggacgcggcggagctggtggag------gaggcgctg	Protospacer
*.*********.****************      *.*      

4. spacer 2.1|1136673|37|NC_005835|CRISPRCasFinder,CRT matches to NZ_CP032341 (Azospirillum brasilense strain MTCC4038 plasmid p2, complete sequence) position: , mismatch: 9, identity: 0.757

cgaggaggacgtggcggagctggtggagcttcttggg------	CRISPR spacer
caaggaggacgcggcggagctggtggag------gaggcgctg	Protospacer
*.*********.****************      *.*      

5. spacer 1.2|541269|37|NC_005835|PILER-CR matches to NC_017273 (Thermus thermophilus SG0.5JP17-16 plasmid pTHTHE1601, complete sequence) position: , mismatch: 10, identity: 0.73

gcctccaccatggggaggaggccctcctccctcgcca	CRISPR spacer
ccctccaccagggggaggagggcctcctcgtccaggg	Protospacer
 ********* ********** ******* ..*.  .

6. spacer 1.2|541269|37|NC_005835|PILER-CR matches to NC_017588 (Thermus thermophilus JL-18 plasmid pTTJL1801, complete sequence) position: , mismatch: 10, identity: 0.73

gcctccaccatggggaggaggccctcctccctcgcca	CRISPR spacer
ccctccaccagggggaggagggcctcctcgtccaggg	Protospacer
 ********* ********** ******* ..*.  .

7. spacer 2.1|1136673|37|NC_005835|CRISPRCasFinder,CRT matches to NZ_CP022363 (Azospirillum sp. TSH58 plasmid TSH58_p03, complete sequence) position: , mismatch: 10, identity: 0.73

cgaggaggacgtggcggagctggtggagcttcttggg------	CRISPR spacer
caaggaggacgcggcggagctgatggag------gaggcgctg	Protospacer
*.*********.**********.*****      *.*      

8. spacer 2.1|1136673|37|NC_005835|CRISPRCasFinder,CRT matches to NZ_CP032347 (Azospirillum brasilense strain MTCC4039 plasmid p2, complete sequence) position: , mismatch: 10, identity: 0.73

cgaggaggacgtggcggagctggtggagcttcttggg------	CRISPR spacer
caaggaggacgcggcggagttggtggag------gaggcgctg	Protospacer
*.*********.*******.********      *.*      

9. spacer 1.2|541269|37|NC_005835|PILER-CR matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 16, identity: 0.568

gcctccaccatggggaggaggccctcctccctcgcca------	CRISPR spacer
------ccctggacgaggaggccctcctccccctggtggaacg	Protospacer
       **  *. *****************.*          

10. spacer 1.2|541269|37|NC_005835|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 16, identity: 0.568

gcctccaccatggggaggaggccctcctccctcgcca------	CRISPR spacer
------ccctggacgaggaggccctcctccccctggtggaacg	Protospacer
       **  *. *****************.*          

11. spacer 1.2|541269|37|NC_005835|PILER-CR matches to NZ_AP019802 (Thermus thermophilus strain HC11 plasmid pHC11, complete sequence) position: , mismatch: 16, identity: 0.568

gcctccaccatggggaggaggccctcctccctcgcca------	CRISPR spacer
------ccctggacgaggaggccctcctccccctggtggaacg	Protospacer
       **  *. *****************.*          

12. spacer 1.2|541269|37|NC_005835|PILER-CR matches to NZ_LR027520 (Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence) position: , mismatch: 16, identity: 0.568

gcctccaccatggggaggaggccctcctccctcgcca------	CRISPR spacer
------ccctggacgaggaggccctcctccccctggtggaacg	Protospacer
       **  *. *****************.*          

2. NC_005838

CRISPR-Cas detection and classification

Crispr_ID: NC_005838_1

• CRISPR_ID: NC_005838_1
• CRISPR_location: 2352-2578
• CRISPR_type: Orphan
• Repeat_type: NA
• Spacer_info: 2 spacers

Consensus repeat of NC_005838_1

Consensus_repeat	Method
TCCAGCTTGGTCTCCACCTCCTGGATCCGCCTCTCCAGC	PILER-CR

spacers of NC_005838_1

>1.1|2391|60|NC_005838|PILER-CR
TTGGTTTCCACCGCGTGGATCCGGGCCTCCAGTTGGGCCTCCGTCTCTTGGATCTGCCGG
>1.2|2490|60|NC_005838|PILER-CR
CGGGTCTCCGTCTCCTGGATCTGCCGCCCCAGCCTGGCCTCCAGGTTCTGAATCCGACTC

CRISPR arrays and Neighbor proteins around NC_005838_1

CRISPR arrays

The CRISPR arrays of NC_005838_1

>merge|NC_005838|1|2352-2578|PILER-CR
TCTCCACCTCTTGGATCCGCCCTTCCAGCTTGGTTTCCACCGCGTGGATCCGGGCCTCCAGTTGGGCCTCCGTCTCTTGGATCTGCCGGTCTAGCTTGGCCTCCACCTCCTGGATCCGGGTCCCCAGCCGGGTCTCCGTCTCCTGGATCTGCCGCCCCAGCCTGGCCTCCAGGTTCTGAATCCGACTCTCCAGCTTGGTCTCCACCTCCTGGATCCGCTTCTCCAAG

>NC_005838|1|1|2352-2578|PILER-CR
TCTCCACCTCTTGGATCCGCCCTTCCAGCTTGGTTTCCA	CCGCGTGGATCCGGGCCTCCAGTTGGGCCTCCGTCTCTTGGATCTGCCGGTCTAGCTTGG
CCTCCACCTCCTGGATCCGGGTCCCCAGCCGGGTCTCCG	TCTCCTGGATCTGCCGCCCCAGCCTGGCCTCCAGGTTCTGAATCCGACTCTCCAGCTTGG
TCTCCACCTCCTGGATCCGCTTCTCCAAG

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005838.1|WP_011174550.1|300_1623_-|cobyrinate-a,c-diamide-synthase	unknown	unknown	gnl|CDD|234896
NC_005838.1|WP_008631412.1|10381_11245_+|precorrin-3B-C(17)-methyltransferase	unknown	unknown	gnl|CDD|381173
NC_005838.1|WP_011174543.1|8965_9637_+|precorrin-2-C(20)-methyltransferase	unknown	unknown	gnl|CDD|381172
NC_005838.1|WP_011174546.1|4508_5042_+|histidine-phosphatase-family-protein	unknown	unknown	gnl|CDD|366010
NC_005838.1|WP_008631402.1|5965_7066_+|cobalt-precorrin-5B-(C(1))-methyltransferase	unknown	unknown	gnl|CDD|234615
NC_005838.1|WP_011174544.1|7058_7757_+|precorrin-8X-methylmutase	unknown	unknown	gnl|CDD|376825
NC_005838.1|WP_008631406.1|7757_8969_+|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase/cobalt-precorrin-6B-(C(15))-methyltransferase	unknown	unknown	gnl|CDD|381171
NC_005838.1|WP_011174545.1|5306_5969_+|nickel-permease	unknown	unknown	gnl|CDD|225911
NC_005838.1|WP_008631410.1|9633_10377_+|cobalt-precorrin-4/precorrin-4-C(11)-methyltransferase	unknown	unknown	gnl|CDD|381168
NC_005838.1|WP_011174547.1|3474_4485_-|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase	unknown	unknown	gnl|CDD|376752
NC_005838.1|WP_008631380.1|1622_2186_-|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	unknown	unknown	gnl|CDD|376827
NC_005838.1|WP_011174548.1|2758_3478_-|adenosylcobinamide-GDP-ribazoletransferase	unknown	unknown	gnl|CDD|376881

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005838.1|WP_011174550.1|300_1623_-|cobyrinate-a,c-diamide-synthase	gnl|CDD|234896	PRK01077, PRK01077, cobyrinate a,c-diamide synthase.	0
NC_005838.1|WP_008631412.1|10381_11245_+|precorrin-3B-C(17)-methyltransferase	gnl|CDD|381173	cd11646, Precorrin_3B_C17_MT, Precorrin-3B C(17)-methyltransferase (also named CobJ or CbiH). Precorrin-3B C(17)-methyltransferase participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. This model includes CobJ of the aerobic pathway and CbiH of the anaerobic pathway, both as stand-alone enzymes and when CobJ or CbiH form part of bifunctional enzymes, such as in Mycobacterium tuberculosis CobIJ where CobJ fuses with a precorrin-2 C(20)-methyltransferase domain, or Bacillus megaterium CbiH60, where CbiH is fused to a nitrite and sulfite reductase-like domain. In the aerobic pathway, once CobG has generated precorrin-3b, CobJ catalyzes the methylation of precorrin-3b at C-17 to form precorrin-4 (the extruded methylated C-20 fragment is left attached as an acyl group at C-1). In the corresponding anaerobic pathway, CbiH carries out this ring contraction, using cobalt-precorrin-3b as a substrate to generate a tetramethylated delta-lactone.	2.16603e-133
NC_005838.1|WP_011174543.1|8965_9637_+|precorrin-2-C(20)-methyltransferase	gnl|CDD|381172	cd11645, Precorrin_2_C20_MT, Precorrin-2 C20-methyltransferase, also named CobI or CbiL. Precorrin-2 C20-methyltransferase (also known as S-adenosyl-L-methionine--precorrin-2 methyltransferase) participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways in bacteria. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. Precorrin-2 C20-methyltransferase catalyzes methylation at the C-20 position of a cyclic tetrapyrrole ring of precorrin-2 using S-adenosylmethionine as a methyl group source to produce precorrin-3A. In the anaerobic pathway, cobalt is inserted into precorrin-2 by CbiK to generate cobalt-precorrin-2, which is the substrate for CbiL, a C20 methyltransferase. In Clostridium difficile, CbiK and CbiL are fused into a bifunctional enzyme. In the aerobic pathway, the precorrin-2 C20-methyltransferase is named CobI. This family includes CbiL and CobI precorrin-2 C20-methyltransferases, both as stand-alone enzymes and when CbiL forms part of a bifunctional enzyme.	1.43207e-55
NC_005838.1|WP_011174546.1|4508_5042_+|histidine-phosphatase-family-protein	gnl|CDD|366010	pfam00300, His_Phos_1, Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centers on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	9.70287e-46
NC_005838.1|WP_008631402.1|5965_7066_+|cobalt-precorrin-5B-(C(1))-methyltransferase	gnl|CDD|234615	PRK00075, cbiD, cobalt-precorrin-6A synthase; Reviewed.	9.12503e-144
NC_005838.1|WP_011174544.1|7058_7757_+|precorrin-8X-methylmutase	gnl|CDD|376825	pfam02570, CbiC, Precorrin-8X methylmutase. This is a family Precorrin-8X methylmutases also known as Precorrin isomerase, CbiC/CobH, EC:5.4.1.2. This enzyme catalyzes the reaction: Precorrin-8X <=> hydrogenobyrinate. This enzyme is part of the Cobalamin (vitamin B12) biosynthetic pathway and catalyzes a methyl rearrangement.	3.04293e-95
NC_005838.1|WP_008631406.1|7757_8969_+|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase/cobalt-precorrin-6B-(C(15))-methyltransferase	gnl|CDD|381171	cd11644, Precorrin-6Y-MT, Precorrin-6Y methyltransferase (also named CbiE). CbiE (precorrin-6Y methyltransferase, also known as cobalt-precorrin-7 C(5)-methyltransferase, also known as cobalt-precorrin-6Y C(5)-methyltransferase) catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8. It participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways in bacteria. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. CbiE functions in the anaerobic pathway, it is a subunit of precorrin-6Y C5,15-methyltransferase, a bifunctional enzyme: cobalt-precorrin-7 C(5)-methyltransferase (CbiE)/cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) (CbiT), that catalyzes two methylations (at C-5 and C-15) in precorrin-6Y, as well as the decarboxylation of the acetate side chain located in ring C, in order to generate precorrin-8X. CbiE and CbiT can be found fused (CbiET, also called CobL), or on separate protein chains (CbiE and CbiT). In the aerobic pathway, a single enzyme called CobL catalyzes the methylations at C-5 and C-15, and the decarboxylation of the C-12 acetate side chain of precorrin-6B.	1.94779e-68
NC_005838.1|WP_011174545.1|5306_5969_+|nickel-permease	gnl|CDD|225911	COG3376, HoxN, High-affinity nickel permease [Inorganic ion transport and metabolism].	2.95572e-12
NC_005838.1|WP_008631410.1|9633_10377_+|cobalt-precorrin-4/precorrin-4-C(11)-methyltransferase	gnl|CDD|381168	cd11641, Precorrin-4_C11-MT, Precorrin-4 C11-methyltransferase (CbiF/CobM). Precorrin-4 C11-methyltransferase participates in the pathway toward the biosynthesis of cobalamin (vitamin B12). There are two distinct cobalamin biosynthetic pathways in bacteria. The aerobic pathway requires oxygen, and cobalt is inserted late in the pathway; the anaerobic pathway does not require oxygen, and cobalt insertion is the first committed step towards cobalamin synthesis. In the aerobic pathway, CobM catalyzes the methylation of precorrin-4 at C-11 to yield precorrin-5. In the anaerobic pathway, CibF catalyzes the methylation of cobalt-precorrin-4 to cobalt-precorrin-5. Both CibF and CobM, which are homologous, are included in this model. There are about 30 enzymes involved in vitamin B12 synthetic pathway. The enzymes involved in the aerobic pathway are prefixed Cob and those of the anaerobic pathway Cbi. Most of the enzymes are shared in both pathways and several of these enzymes are pathway-specific.	8.48483e-96
NC_005838.1|WP_011174547.1|3474_4485_-|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase	gnl|CDD|376752	pfam02277, DBI_PRT, Phosphoribosyltransferase. This family of proteins represent the nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) enzymes involved in dimethylbenzimidazole synthesis. This function is essential to de novo cobalamin (vitamin B12) production in bacteria. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin.	6.53063e-159
NC_005838.1|WP_008631380.1|1622_2186_-|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase	gnl|CDD|376827	pfam02572, CobA_CobO_BtuR, ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin adenosyltransferase, EC:2.5.1.17, involved in cobalamin (vitamin B12) biosynthesis. These enzymes catalyze the adenosylation reaction: ATP + cob(I)alamin + H2O <=> phosphate + diphosphate + adenosylcobalamin.	1.5886e-94
NC_005838.1|WP_011174548.1|2758_3478_-|adenosylcobinamide-GDP-ribazoletransferase	gnl|CDD|376881	pfam02654, CobS, Cobalamin-5-phosphate synthase. This is family of Colbalmin-5-phosphate synthases, CobS, from bacteria. The CobS enzyme catalyzes the synthesis of AdoCbl-5'-p from AdoCbi-GDP and alpha-ribazole-5'-P. This enzyme is involved in the cobalamin (vitamin B12) biosynthesis pathway in particular the nucleotide loop assembly stage in conjunction with CobC, CobU and CobT.	1.19505e-36

Protein sequences

>NC_005838.1|WP_008631380.1|1622_2186_-|cob(I)yrinic-acid-a,c-diamide-adenosyltransferase
MEEPKRQKPYAKPQGERRGLLLVYTGDGKGKSTAAFGLALRAHGRGLKVRIFQFIKHGTARFGEHRAFSLLGIPIEGLGDGFTWRSRDLARSAALAQEGWGRAKEALLSGTYDLVVLDEATYPLRYGWVSLEEFLEVLRARPPHVHVVVTGRGAPEALLELADTVTEMRKVKHAFDQGVPAQRGIEH
>NC_005838.1|WP_011174550.1|300_1623_-|cobyrinate-a,c-diamide-synthase
MRLLLAAPHSGAGKTTVSLALLLALRARGLRVQPFKVGPDYIDPTHLEKAAARRPYNLDGFFLDETGLLALFRHGARGADFALIEGVMGLFDGKDPRGEVGSTAQVARLLKAPVALVVDAKGMAGSIAPLALGFRDFHPGVRVVGVFANRVGSERHAEILKEALKAVGLPLLGWLPQDPALELPERHLGLVLAGEVAPPLEALRRAFRVDLEGVLRLAASAPPLPEARPFLPPRRPPRARVAYAWDKAFSFYYPEALELLEALGAELVPFSPLEDEALPKAHALLLGGGYPELFAERLSANVALREAIRRFPGPIVAECGGYMYLSQGLWVGERFFPMVGLVPGEARMAERPVLGYREVEALRDSPVARKGQAFKGHEFHYARLPASPSPAWRRLGGEEVEGYTDGRVLASFVHLYLPARPEGVERLLGLASRGKAAGAS
>NC_005838.1|WP_011174548.1|2758_3478_-|adenosylcobinamide-GDP-ribazoletransferase
MKAFRLALALLTVLPLAPKGVGEEDFKRSVAFFPLAGYLLGLPLALLALLPLPPGLSAALGVALLLGLTGFLHLDGLLDLADALLGARPREERLRILKDPHLGAFAFGVGGVYLLLLFQALALVQDPLFLLLFPGWARFAFLPFLHRYPLLGPGMAALVRGGPWPFALLPALPFLLLYPLPALLALLAAWGVARLAWARLGGLNGDALGAMIALGEVVLLLAQALLGPAPSSRAGPGLP
>NC_005838.1|WP_011174547.1|3474_4485_-|nicotinate-nucleotide--dimethylbenzimidazole-phosphoribosyltransferase
MVDPEVFAQARLRMDQLTKPPRALGYLEEVALRLAALQGRVKPELGRGAVVVAAADHGVVAEGVSAYPQEVTRQMVLNFLSGGAAINQFALTADCAVYVLDVGVVGELPDHPGLLKRKVRPGTANLARGPAMTPEEAERALLAGREAARRAIAEGATLLAAGDMGIGNTTAAAALTAALLGLPPEAVVGRGTGVGEEGLRRKREAVARALARLHPGMGPLEVAAEVGGLELVAIAGVYLEGYEAGLPLVLDGFPVTAGALLAWKMAPGLRDHLFAGHLSREPGHRHQLEALGLRPLLDLDLALGEGTGAVLAMPLLRAAARILHMATFQEAGVSRG
>NC_005838.1|WP_011174546.1|4508_5042_+|histidine-phosphatase-family-protein
MELWLVRHGETLWNREGRLLGWTDLPLTAEGEAQARRLKGALPSLPAFSSDLLRARQTAELAGFSPRLYPELREIHFGALEGALWETLDPRYKEALLRFQGFHPPGGESLSAFQERVFRFLEGLKAPAVLFTHGGVVRAVLRALGEDGLVPPGSAVAVDWPRRVLVRLALDGEEATG
>NC_005838.1|WP_011174545.1|5306_5969_+|nickel-permease
MTGLELLAVALGMRHGVDPDHLAAVDGLSRVRPSPLNGVLFALGHGGVVTLLAFPAASLLGRVDLEALHLPAFLLLLVAALNLYRLLKPTPPTPPKGLPLLNPLLLGVLFGLGFETASQLSALALSAELSPLRLGAFFTLGMLLVDGVDGLLASRLQNLAKDSRRAEEASRLLGWAVVAVALVLALAELGGVDLEAFALPLGLGLFGLLVSLRLYALRPA
>NC_005838.1|WP_008631402.1|5965_7066_+|cobalt-precorrin-5B-(C(1))-methyltransferase
MSHPYPPPRDKKGSRIGFTTGANAAAAAKAAALALLGEAPEVVDIWLPAGWRQPFRVFRLERKGDGVLVGMIKDAGDDPDVTHGAEIQAFVRFASEDRLEGGEGVGVVTKPGLGVPVGEPAINPVPRRMIWEAVREVTERPLAVTIAIPGGEELAKKTLNPRLGILGGLSVLGTTGVVKPYSTSAFRMSVVQAVGVARANGLLEIAATTGGKSERFAQRLLPHLPEMAFIEMGDFVGDVLRAARKVGVEVVRVVGMIGKISKMADGKTMTHAAGGEVNLSLLLSLLKEAGASPKALKEAEGAATARRFLEIALEEGLELFFVNLVRLAQEKLQAYIGERPFVSVALTDFDEGRCLAAWPDREVYRG
>NC_005838.1|WP_011174544.1|7058_7757_+|precorrin-8X-methylmutase
MDDLIKAQKNPAHQMTEKGRAIEEESFRIVDQEAGPHGFSPLEWPVVRRMIHATADFEYKALTRFSQGAVEAGLKAIQAGARILVDARMIACGLNPERLRLFGNEVVELLAHPEVVARAKATGGTRAEAAVAYAWEKGLLDGAIVGVGNAPTFLLALVEAIRQGARPALVLGMPVGFVNVLEAKRALMEAPVPWIVTEGRKGGSTLVVAALHALIRLAADGGVDTSRAYREG
>NC_005838.1|WP_008631406.1|7757_8969_+|bifunctional-cobalt-precorrin-7-(C(5))-methyltransferase/cobalt-precorrin-6B-(C(15))-methyltransferase
MVYVIGMGARGREGLSLKALRRLEEAEVLIGGRRHLAHFPDHPGEKVPVQGPLEALLDLAEARLKEGKKVAFLASGDPLFYGIGKRVLERFPEAEVHPAPTAFQEAFARLKLPWDQARFFSLHGRPLGGVLLELSLSPLSVVYTDPEHTPAGIARALLEMGVDARAHVAERLGEEDERVRSFAGLKEVAEERFLDPNVLILEAKGPLPPRLGFFPDEAFEQRMPKKGLITKREVRLLALGLLGLPPDGVLWDIGAGTGSVGIEAARLAPWGEVYAVEKNPESWPHIVENARRFGAFNLHLVKGEAPEALKGLPAPHAVFVGGSGGELEEILRVSLKALRPGGRLVVAAITLENLLAAYGFLKGTGLPLEGFQVQASRVVPLARYHRLEAQNPITLLAVTKEGA
>NC_005838.1|WP_011174543.1|8965_9637_+|precorrin-2-C(20)-methyltransferase
MKLYLIGLGPGDPELLTLKALRLIQRLPVLFYPKEEGREPIALGIARPFLPEGKPLLPLPLFTGGDPKEAERARREAARRVREALSRYGEGGYLVLGDSLLYASPLNLLPHLEGVAVEAVPGISAHQLAAASLLKPIALGEEGFAAVTGLGPVDPEGLDRFQSVFVYKAKDLEALERAFPDREGWAFLRLGMPGERVLPLRAAKGVARDYWTLVGLWRKGGEG
>NC_005838.1|WP_008631410.1|9633_10377_+|cobalt-precorrin-4/precorrin-4-C(11)-methyltransferase
MRPVVHVVGGGPGDPELLTVKGARLLGEARFVLYTGSLFPEGALRELAPKAALLDSKGMTLEEIVLALAEEARKGGGVVRLHSGDPGLYGTLLEEKEALEALGVGVEVVPGVTAAFALAARAGLSLTAPGVAQAVAFTRLGVRTPVPEGQDPKSLARKGLTLAVYLSGMHPRRLSRELLEAGLPGDTPVLYGHKVAQPGEEVGLTDLKGLAHLPARDTTVYLVGEALRAKGVRSLLYDPSFKHRYRR
>NC_005838.1|WP_008631412.1|10381_11245_+|precorrin-3B-C(17)-methyltransferase
MGELFLVGMGPGDLPGLTQRAREALEGAEVVIGYSTYVKLLEEMGLLAGKEVVRKGMTEELDRAEEALERALSGQRVALVSGGDPGIYGMAAPVLELMEERGLKRVDGGVGLPGRFAGEEGEVFLAVIPGVTAANAVASLLGSPLAHDTCLISLSDLLTPWPLIERRLHAAGQGDFVVVLYNPQSKRRDWQLRKSAEILLEYRPKETPAALVKSAYRKRQEVALTTLEGLREAEAGMLTTVVIGNRQSRFYEGTFLTPRGYALKYDLDTKEALPGETPGLSLRRRDA

Crispr_ID: NC_005838_2

• CRISPR_ID: NC_005838_2
• CRISPR_location: 92158-92424
• CRISPR_type: TypeIII
• Repeat_type: III-A
• Spacer_info: 3 spacers
• Cas_protein_info: cas2,cas10,csm2gr11,csm3gr7,csm4gr5,csm5gr7,csx1

Consensus repeat of NC_005838_2

Consensus_repeat	Method
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	PILER-CR
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CRISPRCasFinder
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CRT

spacers of NC_005838_2

>2.1|92194|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT
CGCGATGACGATGCAGGGCGCCGAGTGAAACGTTAAAG
>2.2|92268|41|NC_005838|PILER-CR,CRISPRCasFinder,CRT
ATCACCTTCTTAGGTGTCGGGTTCCTTTTTGCCGTTCTAAC
>2.3|92345|44|NC_005838|PILER-CR,CRISPRCasFinder,CRT
ACCAAGATGTAGTCATCCCCAAAGTCCTTGACGAGCTTAGTCAT

CRISPR arrays and Neighbor proteins around NC_005838_2

CRISPR arrays

The CRISPR arrays of NC_005838_2

>merge|NC_005838|2|92158-92424|PILER-CR,CRISPRCasFinder,CRT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACCGCGATGACGATGCAGGGCGCCGAGTGAAACGTTAAAGGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACATCACCTTCTTAGGTGTCGGGTTCCTTTTTGCCGTTCTAACGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACACCAAGATGTAGTCATCCCCAAAGTCCTTGACGAGCTTAGTCATGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGCC

>NC_005838|2|2|92158-92424|PILER-CR
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CGCGATGACGATGCAGGGCGCCGAGTGAAACGTTAAAG
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	ATCACCTTCTTAGGTGTCGGGTTCCTTTTTGCCGTTCTAAC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	ACCAAGATGTAGTCATCCCCAAAGTCCTTGACGAGCTTAGTCAT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGCC

>NC_005838|2|1|92158-92424|CRISPRCasFinder
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CGCGATGACGATGCAGGGCGCCGAGTGAAACGTTAAAG
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	ATCACCTTCTTAGGTGTCGGGTTCCTTTTTGCCGTTCTAAC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	ACCAAGATGTAGTCATCCCCAAAGTCCTTGACGAGCTTAGTCAT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGCC

>NC_005838|2|1|92158-92424|CRT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CGCGATGACGATGCAGGGCGCCGAGTGAAACGTTAAAG
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	ATCACCTTCTTAGGTGTCGGGTTCCTTTTTGCCGTTCTAAC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	ACCAAGATGTAGTCATCCCCAAAGTCCTTGACGAGCTTAGTCAT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGCC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005838.1|WP_011174453.1|103537_104059_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174457.1|98387_99782_+|type-III-A-CRISPR-associated-protein-Csm6	csx1	cd09747_csx1_CAS-III	gnl|CDD|378236
NC_005838.1|WP_011174470.1|85149_85614_-|cytochrome-P460-family-protein	unknown	unknown	gnl|CDD|379872
NC_005838.1|WP_081424955.1|89722_89902_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174468.1|87906_88227_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_148187560.1|91070_92104_-|IS630-like-element-ISTth6-family-transposase	unknown	unknown	gnl|CDD|315923
NC_005838.1|WP_011174467.1|88320_88851_+|peptide-methionine-(S)-S-oxide-reductase-MsrA	unknown	unknown	gnl|CDD|237597
NC_005838.1|WP_008630619.1|86007_86697_+|IS5-like-element-ISTth7-family-transposase	unknown	unknown	gnl|CDD|376573
NC_005838.1|WP_011174462.1|92781_95199_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl|CDD|274209
NC_005838.1|WP_011174454.1|101656_103567_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174463.1|92453_92726_+|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0081_cas2_CAS-I:CAS-II:CAS-III	gnl|CDD|187856
NC_005838.1|WP_011174466.1|89065_89296_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	unknown	unknown	gnl|CDD|376852
NC_005838.1|WP_011174465.1|89292_89697_+|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350220
NC_005838.1|WP_011174459.1|96350_97226_+|hypothetical-protein	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	gnl|CDD|187794
NC_005838.1|WP_041443908.1|84597_85146_-|MarR-family-transcriptional-regulator	unknown	unknown	gnl|CDD|197670
NC_005838.1|WP_011174458.1|97222_98377_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl|CDD|273863
NC_005838.1|WP_011174456.1|99852_100311_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174461.1|95199_95604_+|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	gnl|CDD|187778
NC_005838.1|WP_011174469.1|86729_87827_-|IS4-like-element-ISTth2-family-transposase	unknown	unknown	gnl|CDD|376573
NC_005838.1|WP_011174460.1|95615_96341_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl|CDD|187815

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_005838.1|WP_011174457.1|98387_99782_+|type-III-A-CRISPR-associated-protein-Csm6	csx1	cd09747_csx1_CAS-III	1e-104	345.2	0.0
NC_005838.1|WP_011174459.1|96350_97226_+|hypothetical-protein	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	1.6e-60	199.8	0.0
NC_005838.1|WP_011174461.1|95199_95604_+|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	1.3e-25	84.9	2.6
NC_005838.1|WP_011174458.1|97222_98377_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	8.1e-24	79.2	0.0
NC_005838.1|WP_011174462.1|92781_95199_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	2.5e-164	543.0	0.0
NC_005838.1|WP_011174463.1|92453_92726_+|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0081_cas2_CAS-I:CAS-II:CAS-III	7.3e-51	165.3	0.9
NC_005838.1|WP_011174460.1|95615_96341_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	9e-80	262.2	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005838.1|WP_011174457.1|98387_99782_+|type-III-A-CRISPR-associated-protein-Csm6	gnl|CDD|378236	pfam09670, Cas_Cas02710, CRISPR-associated protein (Cas_Cas02710). Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).	8.39079e-125
NC_005838.1|WP_011174470.1|85149_85614_-|cytochrome-P460-family-protein	gnl|CDD|379872	pfam16694, Cytochrome_P460, Cytochrome P460.	1.42814e-41
NC_005838.1|WP_011174461.1|95199_95604_+|type-III-A-CRISPR-associated-protein-Csm2	gnl|CDD|187778	cd09647, Csm2_III-A, CRISPR/Cas system-associated protein Csm2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; signature gene for subtype III-A.	5.43062e-18
NC_005838.1|WP_148187560.1|91070_92104_-|IS630-like-element-ISTth6-family-transposase	gnl|CDD|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	2.53286e-26
NC_005838.1|WP_011174467.1|88320_88851_+|peptide-methionine-(S)-S-oxide-reductase-MsrA	gnl|CDD|237597	PRK14054, PRK14054, peptide-methionine (S)-S-oxide reductase.	4.07493e-98
NC_005838.1|WP_008630619.1|86007_86697_+|IS5-like-element-ISTth7-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	0.00046212
NC_005838.1|WP_011174462.1|92781_95199_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl|CDD|274209	TIGR02578, CRISPR-associated_protein_Cas10/Csm1, CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2. A typical example is TM1811 from Thermotoga maritima. CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats. This protein family belongs to a conserved gene cluster regularly found near CRISPR repeats.	0
NC_005838.1|WP_011174463.1|92453_92726_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.97709e-24
NC_005838.1|WP_011174466.1|89065_89296_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin	gnl|CDD|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	1.09542e-05
NC_005838.1|WP_011174465.1|89292_89697_+|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350220	cd09872, PIN_Sll0205-like, VapC-like PIN domain of Sll0205 protein and homologs. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of the Synechocystis sp. (strain PCC 6803) Sll0205 protein and other uncharacterized homologs are included in this subfamily. They are similar to the PIN domains of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	3.05679e-39
NC_005838.1|WP_011174459.1|96350_97226_+|hypothetical-protein	gnl|CDD|187794	cd09663, Csm4_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	4.10391e-11
NC_005838.1|WP_041443908.1|84597_85146_-|MarR-family-transcriptional-regulator	gnl|CDD|197670	smart00347, HTH_MARR, helix_turn_helix multiple antibiotic resistance protein.	1.81474e-14
NC_005838.1|WP_011174458.1|97222_98377_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl|CDD|273863	TIGR01899, cas_TM1807_csm5, CRISPR type III-A/MTUBE-associated RAMP protein Csm5. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. Members of this cas gene family are found in the mtube subtype of CRISPR/cas locus and designated Csm5, for CRISPR/cas Subtype Mtube, protein 5.	1.01226e-19
NC_005838.1|WP_011174469.1|86729_87827_-|IS4-like-element-ISTth2-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	4.06099e-09
NC_005838.1|WP_011174460.1|95615_96341_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl|CDD|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.17461e-104

Protein sequences

>NC_005838.1|WP_148187560.1|91070_92104_-|IS630-like-element-ISTth6-family-transposase
MAAPLRIQLTPEEDRLLLELSLDPRTHKKTRLWAMMVRLAAEGWTAPKIAQHFHKDRTTVYLVLRRFVREGLQGLAYRKPPGAPRKFTPEMAAFVEERLAEDRVWTAPQLAAALAERFGVRLAPKVVARHLRAMGYVWRRTRYVPLGKPTEEEVKAFAEEEGEGKKGAEEGVMEVGYLDESGFSLTLPPTYAWGRRGEAKGVPRAWGSRGRVNVVGHLVRGREGERLFFALLEGPVRWEVVRGYLDRVAEGLAKPLKVFMDNAPFHRSREVEGRKEAWRERGLMVAYLPRYSPHLNPMESVWRRVKGFLMPRRHYGSVEELKEAVAQALKALGGVELKILGEGT
>NC_005838.1|WP_081424955.1|89722_89902_+|hypothetical-protein
MEAVAEADAHLKGLLAELEAVATLRQAKYHLDQVGRGRAIAVYRDPATGEPVYRTPVIG
>NC_005838.1|WP_011174465.1|89292_89697_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MKGPLVLDTHAWVWYLASPEVLPKGLVRVLDEARAREALYISAITPWEVAVLAQKGRIAFSLEPRRWLEEALRVRGIGVVPLDAGIALEAAHLDLPHPDPADRFILATALRLGAVLVTKDERLRRYAKARSLWG
>NC_005838.1|WP_011174466.1|89065_89296_+|type-II-toxin-antitoxin-system-Phd/YefM-family-antitoxin
MTLVMKVSKSYFKAHALELLRRVEATGEPLILTDRGRPVLEVRPYREEDPREKLLGTLLRYEDPTEPTGEAWEALG
>NC_005838.1|WP_011174467.1|88320_88851_+|peptide-methionine-(S)-S-oxide-reductase-MsrA
MPEEIATLAGGCFWCTEAAFKLLRGVLEVVPGYAGGHVPHPTYEEVCTGTTGHREAVQVRFDPGVLPYADLLRYFFAVHDPTSEDRQGPDVGPQYSPAIFYHSEEQKRVAEAVMRELAPLYPKPIATKLLPFTTFYPAEAYHRDYFARHPEAPYCRLVIAPKLEKARKAFKSLLRP
>NC_005838.1|WP_011174468.1|87906_88227_-|hypothetical-protein
MAHYLVRARLRPELAEELREKLRRREFLALKPFGQALTHALEGARRDPATGEAVWEEEDYCTPPLAMERAAVLDRYFLDLRVERVEEGEGFRRIAHLPSLWEPPDR
>NC_005838.1|WP_011174469.1|86729_87827_-|IS4-like-element-ISTth2-family-transposase
MPPTTPLSQVITLWVHKAFASLRKTIRSNLALFLSTLLAAPLDPTLSDLARRTPLPTLAQSRLNRLWRFLHHPTLQNPWALTEALLPLLARRFPKDRPLPLIVDWTFAEDGRHQALVAALPLKGRALVVAFALHPLPPFPSQNRVEEEFLHRLGRAVQDLGYTPLFLLDRGFDRVSLMRKLQGWGMGFLIRLRQNREVEPRGGKRLPLKEGYRRVVHPLREEVRLFGHGGEEVEVTLLVYPGGREPWYLAYSGPFGGKPPYGWRMWIEEGFRDLKGQGFGLDRHRLRTGASLRGWLWLLALGMALLILLGARLQGREWLPRLLAHPERQSLFRLGRIALAQGPPPWREAVVEELIRLLQELGGGK
>NC_005838.1|WP_008630619.1|86007_86697_+|IS5-like-element-ISTth7-family-transposase
MRPSWRGFPGNWRPISPRSPRRKAKRLRTRRRHTWRRFPPLYLMDTTGLAYRSKDRLLRFRRGKEVRRVRGHARLLALMRWDRERRLLWPWGGVVGEGYAPDPRLGGEVLRRFPPSRGWLLADAGFDGKEVWGVLGEAGVRPVIRLRGGGEAREEARVRAREGWDPEVYRFRGVVEGVFGGMKTRLGGGYLWERKPWTAMARALLELIAYGLRVLLSLLPPPPGYKAIY
>NC_005838.1|WP_011174470.1|85149_85614_-|cytochrome-P460-family-protein
MKRSWPLFAVLAVLGLAQGGLPYPEGYRFWTHVKSMELKPGHPLYESFGGLHHIYVNPTGLRTYLEGKKAPFPKGTVIVFDLLEAKVEGNALLEGPRKLIGVMAKDPGRYPDTGGWGYYAFGPDKKPLAIDPKACHACHQGAANTDYVFSAFRP
>NC_005838.1|WP_041443908.1|84597_85146_-|MarR-family-transcriptional-regulator
MGVEEKLLALLERLAQAERALLTREAHRLGLTATQAHLLLHLAERPQGVVDLAALFALTPATVSEALAALERKGLLRREKDEKDRRRWRLKPTKEGQALAQALKGYAAPLSQALGEVEDPEGLLLGLLHLLAALVRQGVMAETGLCLTCRHLRREEGFFCALLQIPLAPLDLRLACPDHAPA
>NC_005838.1|WP_011174463.1|92453_92726_+|CRISPR-associated-endonuclease-Cas2
MGKRLYAVAYDIPDDTRRVKLANLLKSYGERVQLSVFECYLDERLLEDLRRRARRLLDLGQDALRIYPVAGQVEVLGVGPLPELREVQVL
>NC_005838.1|WP_011174462.1|92781_95199_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MLGDGLSVALAGLLHDVGKLYSRARWGERDDRVPDRTHTAYTAHFFREHAGLFRGAGLDPDWLARTASRHHEGWRDRPQYRPETPEEWCVALADTYASKEREEGEGGGSPPEVPLSPPFRRLLLGGEEGREGGYSPVGAGGRVGLEAGGLYPEERPNVSKDVYKRLLERLEGRLEEMARFSLGKEALVLNLALALQETLSLVPSDTQSEPDVSLYDHLRLTAAIAHALWLFHGGSPSAQDLRQDGEKFLLVVGDMGGIQGHIYRIAGAEAGVGGIAKRLRARSLEVSLAAEAMALGLLWRLGLTPLNRILGAGGKFYLLLPNTEEARAALEGTREAWGRWALKRGGSLVPHLAWVAFRGQDFRDFAALLKRLHEALAREKLRPFAFLASTGGVLGAPLRPCAACGLEPARRDEPGSLCPDCEREAALGARLPRSDRVGFFLEEAPRPYLDFPGLKVGLGGPLEGAFHLFRARLDFAPWPDPSEAKPLLGHLPRVEHALKAKGWSLEAYRAWAEEEGLLEDEEPHPEKVLTFAELAALSEGAPYLGALMLDADRMGEAFATGFRREGRDLATPSRLAALSRTLEVFFTTEVLTLLEEPRRYRERLGWDDLEAQGKEARYPLLYSVYSGGDDLFLLGPWDALLDFALDLERLYRLFTRHPRLTLSGGFLLVPPSLPVPELARLLGEAEKRAKAEGRERLFLFGQAVPWETLRGLRAWAEGLRQDLRAERVSRAQVYRWLLLWRRFSPLEDPGERMRYKPLLAYALRRVRERDEGAWERYLKLLDHQDPAWTYLPVWVQWALYRERRV
>NC_005838.1|WP_011174461.1|95199_95604_+|type-III-A-CRISPR-associated-protein-Csm2
MPALEFFKDKERGVLDPKVFERAREVAEGLARGKLKSSQFRNYFAELRALENRFERERRKEGEELAFARLVPQLELLRAKLFYNTRSQGPLRDAKEFVEFMEEALEAGKRSPKDFEAMMKYVEAVLAYFYALAK
>NC_005838.1|WP_011174460.1|95615_96341_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MKLKKVIRIRSVLLAKTGLRIGMSRDQMAIGDLDNPVVRNPLTDEPYIPGSSLKGKLRYLLEWSLGGDYILKAKDKHVYASPDPKDPVARIFGLAPENDERSLAVARERGPTRLLVRDAYLTEDAKEALERTSARGGLYTEIKQEVFIPRLGGNANPRTTERVPAGARFRVEMTYRVLDDLDEEYFGKYLLRALELLELDGLGGHISRGYGQVYFLHPERLTEDQEGWPLKERLKVEEVVL
>NC_005838.1|WP_011174459.1|96350_97226_+|hypothetical-protein
MRATLFRLYFQGPLKALPRAPTLLGHLFWWYRYTHGREALEELLERFRQEPPFRLSSVYPEGWLPRPKLPPVQVEETTLRKALKSLSLVRLDTFQALAERGEEALLEAPEVQGKARPPEMRRLRRTRVGVDRAAGTARPGVLFTQEYLFPDPRTPYALYVLGEAPFDLGEALAFVGEMGYGGQASLGLGRFRVEGPFAVELPEAKEPNAYATLAPGPLEEALYYEVEPYWGRLGGAYVGARPFKRPYLRAKEGSVYRGPTHRLLEVTPTEPPEAGTRVWEALVVFPLGVRV
>NC_005838.1|WP_011174458.1|97222_98377_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MRFLRSFRLELEALSPVHVGTGEAYPAYAYVPDFARKAVHLLDPAALLLALPEARRRQYLEKVAQGPKAAQEVLRYLLEEDQLPREAVLHTLPASKAFLEALRSATEEALLEYRPLPRSPLGAYLPGSSVKGALRTAWLFHVLVREGKVAVFDRKEGVWRLRAWREGDGGTHVYPSRNPSLYENQAFEGAVLGYAREGKGRRMSLDLYRDPFRAVRLSDSGPVETFLNRLGVFHPHKDTSRMVLLAETFRIGTRFALTLRYHEGLSRDGDGERGVSMPIPPEDLVRALRDYYGKVAEWEEGFAEEHRLKRALEVYRALRERLQDPEAFPLRVGFGSGRLALRLALLLPEDHPEAQEPKTRKTAGAQNPVDGYPLGWMVGRLEPL
>NC_005838.1|WP_011174457.1|98387_99782_+|type-III-A-CRISPR-associated-protein-Csm6
MEDLDALWERYREAVRAGGNPQALYQEMVWPALLALWREKPRVYPFPQAFAVSVHTLGTSPEATALAILGAGAERVYVLHTPESARFLPRLRQDTGKDLYPVEIGKSDVEAIYREVKRLLEKHPEVPVALDLTSGTKAMSAGLAAAGFFFQRFYPKVRVVYVDNEDYDPELRRPRAGTEKLRILPNPHEALAEVDALFAKELYGKGEFGQAAAYFRGMVGRTGNQAYALYALLAEMYRAWRALDFGEALKAGRKLLGQLSQNVWLNHPLNARREALEAQVALLEAVGRFLKARDFALKEGVYGLARTLLHLAQEAKEEAAVLAALYAYRALELLLQERLALLGRRAEAPGLSPEEAEALRKALAELLGVSPEEVRLPAKLGLLDLLAFLRLKGDEALGRLSLAELRGLAGALKGRNSALLVHGFDVPSPKAVEGIARLAQGLLQDLEARTALGPLSPEPVPLGF
>NC_005838.1|WP_011174456.1|99852_100311_-|hypothetical-protein
MKRKSAYSPSAREKLAFKIPVRRSGQRHYSTSLKRCTPSKCASKRTFATLLPFAIARKMPVPSCQVAPGPGGKAHALSPRHGAHRGGGPPPGLRPPPGGGGPLLLALAEEGLLEVADRAVTPAQMEEAYRRYLGKVAGLGLAKAVLEDREGR
>NC_005838.1|WP_011174454.1|101656_103567_+|hypothetical-protein
MQAPVYLCLLGNDPAPAYLGLKVVEREAGRVAKAVFYSFPAWNEEYGKKRQAFFRLLSEKGVLYEERPLEKGLEEAEAREVWVNLTGGAKYWAVRFLGHWRRPGARVFLVEGHRALEAPRALFLWPREEERSLEAEALTLEEYARLYLEPLGEAWERVSPPGAFPPGAQAARLPGREGGVFVVHRGLPYWYWVRPHLGGEAKEMSRKALSAFSGEAKRLGGQLCLPVVPYHKAHLRSRHPKERENVFARWRAWAREYGVFLVDPGRPLEEEVASLIKGKASKKALPLPQEGPLLLALVSEQAVPLYAAYLHAGPREVYLLTTPEMESRLRWAEAFFRGKGVRVHRSFLSGPWALREVRDLLAPVVEEALRRGHPVHANLNSGTTAMALGLYLALRDGARAHYLDGDRLLLLDGGEAEVPWEEGRPEDLLALRGYRFEEEYPDARPDPGLLALAEEILRRWDEVQTSWEASPLVRRFLKFWKKRFGQAFPPKRLSRLKGLPLEYAVYSHLNAHLAPKGGQARMGGHLVPLGGNEALAPQFTEVDGVFFHRGALWFVECKPTDEGLRERAPIMAELVRSVGGVEARGLMVARRWRGAPPPASPNLVYMALEGGEGVGVYRFPEELEKALSRNPAPRRG
>NC_005838.1|WP_011174453.1|103537_104059_-|hypothetical-protein
MEALWQRTGDPLGDFIRLVLLVEELLERLGAPKEDTLGAKLRSGAAEAFFQSHPEGPALRGRLWRLVELRNAVLHERAEVPSWAFSEGRDLAARLLAAVERQGFYSREEWTARMAFLEAPAPPTPQAFPEVIPPERARSPEAEERPPGAWKTLPFPRRPLAKRALAPPRRRIP

Crispr_ID: NC_005838_3

• CRISPR_ID: NC_005838_3
• CRISPR_location: 100454-101620
• CRISPR_type: TypeIII
• Repeat_type: III-A
• Spacer_info: 15 spacers
• Cas_protein_info: csx1,csm5gr7,csm4gr5,csm3gr7,csm2gr11,cas10,cas2,cmr3gr5,cmr1gr7,cmr4gr7,cmr5gr11

Consensus repeat of NC_005838_3

Consensus_repeat	Method
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACT	PILER-CR
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CRISPRCasFinder
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CRT

spacers of NC_005838_3

>3.1|100491|40|NC_005838|PILER-CR
GGGGTATATCCTCTTTATCCCCGGTATTCTTGACAGGTCT
>3.2|100568|36|NC_005838|PILER-CR
TCACAAAATCGTACTTGAGGCAAGCGAAAGCGACGA
>3.3|100641|37|NC_005838|PILER-CR
CCTGAGGGGGAGGAGGAGGTGGCTTGCGGGTAAAAAA
>3.4|100490|41|NC_005838|CRISPRCasFinder,CRT
TGGGGTATATCCTCTTTATCCCCGGTATTCTTGACAGGTCT
>3.5|100567|37|NC_005838|CRISPRCasFinder,CRT
TTCACAAAATCGTACTTGAGGCAAGCGAAAGCGACGA
>3.6|100640|38|NC_005838|CRISPRCasFinder,CRT
CCCTGAGGGGGAGGAGGAGGTGGCTTGCGGGTAAAAAA
>3.7|100714|42|NC_005838|CRISPRCasFinder,CRT
TTCGAAGCGCCCCGCCCCGAGGCACTTCCCACACCCTTTCCC
>3.8|100792|44|NC_005838|CRISPRCasFinder,CRT
GTGCTCCTTCAAACTCCTCTCCAGAGCCTCCTGGATCAGTTCAT
>3.9|100872|41|NC_005838|CRISPRCasFinder,CRT
TCCTCTATCGCCTTGGCGATGACGCCCCTGATGGCCTCGCG
>3.10|100949|40|NC_005838|CRISPRCasFinder,CRT
ACTCCCTCTACGCCCCCTAACTCGCGGTACGCGAAGAGGG
>3.11|101025|36|NC_005838|CRISPRCasFinder,CRT
GACAGGTAAGGGTGTAGAGGTCGTCCAGCTTCATAA
>3.12|101097|37|NC_005838|CRISPRCasFinder,CRT
AAGTGAGGATGTACCCCCGCCCCTTGAGCTTCTTCTC
>3.13|101170|37|NC_005838|CRISPRCasFinder,CRT
CTTTGCGCCGCGCGGCCTAGCGCCGACCGCGTATCCC
>3.14|101243|37|NC_005838|CRISPRCasFinder,CRT
CTTTAAGGGAGTCGCCTTCGCCCACGTCTTCCTTGGT
>3.15|101316|38|NC_005838|CRISPRCasFinder,CRT
GCGAGGAGCCGCCGCACCCCGATGATGCGCCCCTGGTC
>3.16|101390|40|NC_005838|CRISPRCasFinder,CRT
TCCTTCTTTGGGCCAGCTGATGCCCCAGGCAAGCCCCGGT
>3.17|101466|41|NC_005838|CRISPRCasFinder,CRT
GCTTCTCCGTTGCGCTGAGTTCGCCGTTGCTCCAGACATGG
>3.18|101543|42|NC_005838|CRISPRCasFinder,CRT
GTGTGGCCGCGGCTGCGCGCCGCGCGGCCCTTGCGCCCATGC

CRISPR arrays and Neighbor proteins around NC_005838_3

CRISPR arrays

The CRISPR arrays of NC_005838_3

>merge|NC_005838|3|100454-101620|PILER-CR,CRISPRCasFinder,CRT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACTGGGGTATATCCTCTTTATCCCCGGTATTCTTGACAGGTCTGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACTTCACAAAATCGTACTTGAGGCAAGCGAAAGCGACGAGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACCCCTGAGGGGGAGGAGGAGGTGGCTTGCGGGTAAAAAAGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACTTCGAAGCGCCCCGCCCCGAGGCACTTCCCACACCCTTTCCCGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACGTGCTCCTTCAAACTCCTCTCCAGAGCCTCCTGGATCAGTTCATGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACTCCTCTATCGCCTTGGCGATGACGCCCCTGATGGCCTCGCGGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACACTCCCTCTACGCCCCCTAACTCGCGGTACGCGAAGAGGGGTTGCAAGAGATTGAGCCCCGTAAGGGGATTGCGACGACAGGTAAGGGTGTAGAGGTCGTCCAGCTTCATAAGTTGCAAGAGATTGAGCCCCGTAAGGGGATTGCGACAAGTGAGGATGTACCCCCGCCCCTTGAGCTTCTTCTCGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACCTTTGCGCCGCGCGGCCTAGCGCCGACCGCGTATCCCGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACCTTTAAGGGAGTCGCCTTCGCCCACGTCTTCCTTGGTGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACGCGAGGAGCCGCCGCACCCCGATGATGCGCCCCTGGTCGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACTCCTTCTTTGGGCCAGCTGATGCCCCAGGCAAGCCCCGGTGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACGCTTCTCCGTTGCGCTGAGTTCGCCGTTGCTCCAGACATGGGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACGTGTGGCCGCGGCTGCGCGCCGCGCGGCCCTTGCGCCCATGCGTTGCAAGGGATTGAGCCCCGTAAGGGGATGGCCTC

>NC_005838|3|3|100454-100714|PILER-CR
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACT	GGGGTATATCCTCTTTATCCCCGGTATTCTTGACAGGTCT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACT	TCACAAAATCGTACTTGAGGCAAGCGAAAGCGACGA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACC	CCTGAGGGGGAGGAGGAGGTGGCTTGCGGGTAAAAAA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACT

>NC_005838|3|2|100454-101620|CRISPRCasFinder
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	TGGGGTATATCCTCTTTATCCCCGGTATTCTTGACAGGTCT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	TTCACAAAATCGTACTTGAGGCAAGCGAAAGCGACGA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CCCTGAGGGGGAGGAGGAGGTGGCTTGCGGGTAAAAAA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	TTCGAAGCGCCCCGCCCCGAGGCACTTCCCACACCCTTTCCC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	GTGCTCCTTCAAACTCCTCTCCAGAGCCTCCTGGATCAGTTCAT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	TCCTCTATCGCCTTGGCGATGACGCCCCTGATGGCCTCGCG
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	ACTCCCTCTACGCCCCCTAACTCGCGGTACGCGAAGAGGG
GTTGCAAGAGATTGAGCCCCGTAAGGGGATTGCGAC	GACAGGTAAGGGTGTAGAGGTCGTCCAGCTTCATAA
GTTGCAAGAGATTGAGCCCCGTAAGGGGATTGCGAC	AAGTGAGGATGTACCCCCGCCCCTTGAGCTTCTTCTC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CTTTGCGCCGCGCGGCCTAGCGCCGACCGCGTATCCC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CTTTAAGGGAGTCGCCTTCGCCCACGTCTTCCTTGGT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	GCGAGGAGCCGCCGCACCCCGATGATGCGCCCCTGGTC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	TCCTTCTTTGGGCCAGCTGATGCCCCAGGCAAGCCCCGGT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	GCTTCTCCGTTGCGCTGAGTTCGCCGTTGCTCCAGACATGG
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	GTGTGGCCGCGGCTGCGCGCCGCGCGGCCCTTGCGCCCATGC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATGGCCTC

>NC_005838|3|2|100454-101620|CRT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	TGGGGTATATCCTCTTTATCCCCGGTATTCTTGACAGGTCT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	TTCACAAAATCGTACTTGAGGCAAGCGAAAGCGACGA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CCCTGAGGGGGAGGAGGAGGTGGCTTGCGGGTAAAAAA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	TTCGAAGCGCCCCGCCCCGAGGCACTTCCCACACCCTTTCCC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	GTGCTCCTTCAAACTCCTCTCCAGAGCCTCCTGGATCAGTTCAT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	TCCTCTATCGCCTTGGCGATGACGCCCCTGATGGCCTCGCG
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	ACTCCCTCTACGCCCCCTAACTCGCGGTACGCGAAGAGGG
GTTGCAAGAGATTGAGCCCCGTAAGGGGATTGCGAC	GACAGGTAAGGGTGTAGAGGTCGTCCAGCTTCATAA
GTTGCAAGAGATTGAGCCCCGTAAGGGGATTGCGAC	AAGTGAGGATGTACCCCCGCCCCTTGAGCTTCTTCTC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CTTTGCGCCGCGCGGCCTAGCGCCGACCGCGTATCCC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	CTTTAAGGGAGTCGCCTTCGCCCACGTCTTCCTTGGT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	GCGAGGAGCCGCCGCACCCCGATGATGCGCCCCTGGTC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	TCCTTCTTTGGGCCAGCTGATGCCCCAGGCAAGCCCCGGT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	GCTTCTCCGTTGCGCTGAGTTCGCCGTTGCTCCAGACATGG
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	GTGTGGCCGCGGCTGCGCGCCGCGCGGCCCTTGCGCCCATGC
GTTGCAAGGGATTGAGCCCCGTAAGGGGATGGCCTC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005838.1|WP_011174449.1|106246_108001_+|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	gnl|CDD|274208
NC_005838.1|WP_011174450.1|105709_106120_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174457.1|98387_99782_+|type-III-A-CRISPR-associated-protein-Csm6	csx1	cd09747_csx1_CAS-III	gnl|CDD|378236
NC_005838.1|WP_148187560.1|91070_92104_-|IS630-like-element-ISTth6-family-transposase	unknown	unknown	gnl|CDD|315923
NC_005838.1|WP_011174462.1|92781_95199_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	gnl|CDD|274209
NC_005838.1|WP_011174454.1|101656_103567_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174448.1|107990_109076_+|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	gnl|CDD|187879
NC_005838.1|WP_011174463.1|92453_92726_+|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0081_cas2_CAS-I:CAS-II:CAS-III	gnl|CDD|187856
NC_005838.1|WP_011174451.1|104751_105717_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174446.1|110275_111136_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl|CDD|274210
NC_005838.1|WP_011174453.1|103537_104059_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174459.1|96350_97226_+|hypothetical-protein	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	gnl|CDD|187794
NC_005838.1|WP_011174458.1|97222_98377_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	gnl|CDD|273863
NC_005838.1|WP_011174456.1|99852_100311_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174445.1|111139_111484_+|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	gnl|CDD|378242
NC_005838.1|WP_011174461.1|95199_95604_+|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	gnl|CDD|187778
NC_005838.1|WP_081424955.1|89722_89902_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174452.1|104063_104783_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174447.1|109072_110260_+|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	gnl|CDD|224286
NC_005838.1|WP_011174460.1|95615_96341_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	gnl|CDD|187815

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_005838.1|WP_011174449.1|106246_108001_+|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	cas10	cls000742_cas10_CAS-III	5.1e-132	436.2	0.0
NC_005838.1|WP_011174457.1|98387_99782_+|type-III-A-CRISPR-associated-protein-Csm6	csx1	cd09747_csx1_CAS-III	1e-104	345.2	0.0
NC_005838.1|WP_011174461.1|95199_95604_+|type-III-A-CRISPR-associated-protein-Csm2	csm2gr11	cd09647_csm2gr11_CAS-III-A	1.3e-25	84.9	2.6
NC_005838.1|WP_011174462.1|92781_95199_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	cas10	cd09680_cas10_CAS-III	2.5e-164	543.0	0.0
NC_005838.1|WP_011174448.1|107990_109076_+|type-III-B-CRISPR-module-associated-protein-Cmr3	cmr3gr5	cd09748_cmr3gr5_CAS-III-B	1.7e-97	321.7	6.7
NC_005838.1|WP_011174463.1|92453_92726_+|CRISPR-associated-endonuclease-Cas2	cas2	mkCas0081_cas2_CAS-I:CAS-II:CAS-III	7.3e-51	165.3	0.9
NC_005838.1|WP_011174459.1|96350_97226_+|hypothetical-protein	csm4gr5	mkCas0089_csm4gr5_CAS-III-A:CAS-III-D	1.6e-60	199.8	0.0
NC_005838.1|WP_011174458.1|97222_98377_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	csm5gr7	cd09662_csm5gr7_CAS-III-A	8.1e-24	79.2	0.0
NC_005838.1|WP_011174446.1|110275_111136_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	2.3e-86	284.6	0.0
NC_005838.1|WP_011174445.1|111139_111484_+|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	9.5e-33	107.9	2.7
NC_005838.1|WP_011174447.1|109072_110260_+|type-III-B-CRISPR-module-RAMP-protein-Cmr1	cmr1gr7	COG1367_cmr1gr7_CAS-III-B	1.6e-30	101.1	0.0
NC_005838.1|WP_011174460.1|95615_96341_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	csm3gr7	cd09684_csm3gr7_CAS-III-A:CAS-III-D	9e-80	262.2	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005838.1|WP_011174449.1|106246_108001_+|type-III-B-CRISPR-associated-protein-Cas10/Cmr2	gnl|CDD|274208	TIGR02577, thermophile-specific_DNA_repair_system, CRISPR-associated protein Cas10/Cmr2, subtype III-B. This model represent a Crm2 family of the CRISPR-associated RAMP module, a set of six genes recurring found together in prokaryotic genomes. This gene cluster is found only in species with CRISPR repeats, usually near the repeats themselves. Because most of the six (but not this family) contain RAMP domains, and because its appearance in a genome appears to depend on other CRISPR-associated Cas genes, the set is designated the CRISPR RAMP module. This protein, typified by TM1794 from Thermotoga maritima, is designated Crm2, for CRISPR RAMP Module protein 2.	1.61362e-129
NC_005838.1|WP_011174457.1|98387_99782_+|type-III-A-CRISPR-associated-protein-Csm6	gnl|CDD|378236	pfam09670, Cas_Cas02710, CRISPR-associated protein (Cas_Cas02710). Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).	8.39079e-125
NC_005838.1|WP_148187560.1|91070_92104_-|IS630-like-element-ISTth6-family-transposase	gnl|CDD|315923	pfam13358, DDE_3, DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	2.53286e-26
NC_005838.1|WP_011174462.1|92781_95199_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1	gnl|CDD|274209	TIGR02578, CRISPR-associated_protein_Cas10/Csm1, CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2. A typical example is TM1811 from Thermotoga maritima. CRISPR are Clustered Regularly Interspaced Short Palindromic Repeats. This protein family belongs to a conserved gene cluster regularly found near CRISPR repeats.	0
NC_005838.1|WP_011174448.1|107990_109076_+|type-III-B-CRISPR-module-associated-protein-Cmr3	gnl|CDD|187879	cd09748, Cmr3_III-B, CRISPR/Cas system-associated RAMP superfamily protein Cmr3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein; This protein is a subunit of Cmr complex.	7.00531e-96
NC_005838.1|WP_011174463.1|92453_92726_+|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	2.97709e-24
NC_005838.1|WP_011174459.1|96350_97226_+|hypothetical-protein	gnl|CDD|187794	cd09663, Csm4_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm4. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	4.10391e-11
NC_005838.1|WP_011174458.1|97222_98377_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5	gnl|CDD|273863	TIGR01899, cas_TM1807_csm5, CRISPR type III-A/MTUBE-associated RAMP protein Csm5. CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. Members of this cas gene family are found in the mtube subtype of CRISPR/cas locus and designated Csm5, for CRISPR/cas Subtype Mtube, protein 5.	1.01226e-19
NC_005838.1|WP_011174446.1|110275_111136_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl|CDD|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	4.68724e-107
NC_005838.1|WP_011174445.1|111139_111484_+|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl|CDD|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	2.02437e-32
NC_005838.1|WP_011174461.1|95199_95604_+|type-III-A-CRISPR-associated-protein-Csm2	gnl|CDD|187778	cd09647, Csm2_III-A, CRISPR/Cas system-associated protein Csm2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Small alpha-helical protein; signature gene for subtype III-A.	5.43062e-18
NC_005838.1|WP_011174447.1|109072_110260_+|type-III-B-CRISPR-module-RAMP-protein-Cmr1	gnl|CDD|224286	COG1367, COG1367, CRISPR system related protein, RAMP superfamily [Defense mechanisms].	1.64916e-27
NC_005838.1|WP_011174460.1|95615_96341_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3	gnl|CDD|187815	cd09684, Csm3_III-A, CRISPR/Cas system-associated RAMP superfamily protein Csm3. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; RAMP superfamily protein.	1.17461e-104

Protein sequences

>NC_005838.1|WP_011174456.1|99852_100311_-|hypothetical-protein
MKRKSAYSPSAREKLAFKIPVRRSGQRHYSTSLKRCTPSKCASKRTFATLLPFAIARKMPVPSCQVAPGPGGKAHALSPRHGAHRGGGPPPGLRPPPGGGGPLLLALAEEGLLEVADRAVTPAQMEEAYRRYLGKVAGLGLAKAVLEDREGR
>NC_005838.1|WP_011174457.1|98387_99782_+|type-III-A-CRISPR-associated-protein-Csm6
MEDLDALWERYREAVRAGGNPQALYQEMVWPALLALWREKPRVYPFPQAFAVSVHTLGTSPEATALAILGAGAERVYVLHTPESARFLPRLRQDTGKDLYPVEIGKSDVEAIYREVKRLLEKHPEVPVALDLTSGTKAMSAGLAAAGFFFQRFYPKVRVVYVDNEDYDPELRRPRAGTEKLRILPNPHEALAEVDALFAKELYGKGEFGQAAAYFRGMVGRTGNQAYALYALLAEMYRAWRALDFGEALKAGRKLLGQLSQNVWLNHPLNARREALEAQVALLEAVGRFLKARDFALKEGVYGLARTLLHLAQEAKEEAAVLAALYAYRALELLLQERLALLGRRAEAPGLSPEEAEALRKALAELLGVSPEEVRLPAKLGLLDLLAFLRLKGDEALGRLSLAELRGLAGALKGRNSALLVHGFDVPSPKAVEGIARLAQGLLQDLEARTALGPLSPEPVPLGF
>NC_005838.1|WP_011174458.1|97222_98377_+|type-III-A-CRISPR-associated-RAMP-protein-Csm5
MRFLRSFRLELEALSPVHVGTGEAYPAYAYVPDFARKAVHLLDPAALLLALPEARRRQYLEKVAQGPKAAQEVLRYLLEEDQLPREAVLHTLPASKAFLEALRSATEEALLEYRPLPRSPLGAYLPGSSVKGALRTAWLFHVLVREGKVAVFDRKEGVWRLRAWREGDGGTHVYPSRNPSLYENQAFEGAVLGYAREGKGRRMSLDLYRDPFRAVRLSDSGPVETFLNRLGVFHPHKDTSRMVLLAETFRIGTRFALTLRYHEGLSRDGDGERGVSMPIPPEDLVRALRDYYGKVAEWEEGFAEEHRLKRALEVYRALRERLQDPEAFPLRVGFGSGRLALRLALLLPEDHPEAQEPKTRKTAGAQNPVDGYPLGWMVGRLEPL
>NC_005838.1|WP_011174459.1|96350_97226_+|hypothetical-protein
MRATLFRLYFQGPLKALPRAPTLLGHLFWWYRYTHGREALEELLERFRQEPPFRLSSVYPEGWLPRPKLPPVQVEETTLRKALKSLSLVRLDTFQALAERGEEALLEAPEVQGKARPPEMRRLRRTRVGVDRAAGTARPGVLFTQEYLFPDPRTPYALYVLGEAPFDLGEALAFVGEMGYGGQASLGLGRFRVEGPFAVELPEAKEPNAYATLAPGPLEEALYYEVEPYWGRLGGAYVGARPFKRPYLRAKEGSVYRGPTHRLLEVTPTEPPEAGTRVWEALVVFPLGVRV
>NC_005838.1|WP_011174460.1|95615_96341_+|type-III-A-CRISPR-associated-RAMP-protein-Csm3
MKLKKVIRIRSVLLAKTGLRIGMSRDQMAIGDLDNPVVRNPLTDEPYIPGSSLKGKLRYLLEWSLGGDYILKAKDKHVYASPDPKDPVARIFGLAPENDERSLAVARERGPTRLLVRDAYLTEDAKEALERTSARGGLYTEIKQEVFIPRLGGNANPRTTERVPAGARFRVEMTYRVLDDLDEEYFGKYLLRALELLELDGLGGHISRGYGQVYFLHPERLTEDQEGWPLKERLKVEEVVL
>NC_005838.1|WP_011174461.1|95199_95604_+|type-III-A-CRISPR-associated-protein-Csm2
MPALEFFKDKERGVLDPKVFERAREVAEGLARGKLKSSQFRNYFAELRALENRFERERRKEGEELAFARLVPQLELLRAKLFYNTRSQGPLRDAKEFVEFMEEALEAGKRSPKDFEAMMKYVEAVLAYFYALAK
>NC_005838.1|WP_011174462.1|92781_95199_+|type-III-A-CRISPR-associated-protein-Cas10/Csm1
MLGDGLSVALAGLLHDVGKLYSRARWGERDDRVPDRTHTAYTAHFFREHAGLFRGAGLDPDWLARTASRHHEGWRDRPQYRPETPEEWCVALADTYASKEREEGEGGGSPPEVPLSPPFRRLLLGGEEGREGGYSPVGAGGRVGLEAGGLYPEERPNVSKDVYKRLLERLEGRLEEMARFSLGKEALVLNLALALQETLSLVPSDTQSEPDVSLYDHLRLTAAIAHALWLFHGGSPSAQDLRQDGEKFLLVVGDMGGIQGHIYRIAGAEAGVGGIAKRLRARSLEVSLAAEAMALGLLWRLGLTPLNRILGAGGKFYLLLPNTEEARAALEGTREAWGRWALKRGGSLVPHLAWVAFRGQDFRDFAALLKRLHEALAREKLRPFAFLASTGGVLGAPLRPCAACGLEPARRDEPGSLCPDCEREAALGARLPRSDRVGFFLEEAPRPYLDFPGLKVGLGGPLEGAFHLFRARLDFAPWPDPSEAKPLLGHLPRVEHALKAKGWSLEAYRAWAEEEGLLEDEEPHPEKVLTFAELAALSEGAPYLGALMLDADRMGEAFATGFRREGRDLATPSRLAALSRTLEVFFTTEVLTLLEEPRRYRERLGWDDLEAQGKEARYPLLYSVYSGGDDLFLLGPWDALLDFALDLERLYRLFTRHPRLTLSGGFLLVPPSLPVPELARLLGEAEKRAKAEGRERLFLFGQAVPWETLRGLRAWAEGLRQDLRAERVSRAQVYRWLLLWRRFSPLEDPGERMRYKPLLAYALRRVRERDEGAWERYLKLLDHQDPAWTYLPVWVQWALYRERRV
>NC_005838.1|WP_011174463.1|92453_92726_+|CRISPR-associated-endonuclease-Cas2
MGKRLYAVAYDIPDDTRRVKLANLLKSYGERVQLSVFECYLDERLLEDLRRRARRLLDLGQDALRIYPVAGQVEVLGVGPLPELREVQVL
>NC_005838.1|WP_148187560.1|91070_92104_-|IS630-like-element-ISTth6-family-transposase
MAAPLRIQLTPEEDRLLLELSLDPRTHKKTRLWAMMVRLAAEGWTAPKIAQHFHKDRTTVYLVLRRFVREGLQGLAYRKPPGAPRKFTPEMAAFVEERLAEDRVWTAPQLAAALAERFGVRLAPKVVARHLRAMGYVWRRTRYVPLGKPTEEEVKAFAEEEGEGKKGAEEGVMEVGYLDESGFSLTLPPTYAWGRRGEAKGVPRAWGSRGRVNVVGHLVRGREGERLFFALLEGPVRWEVVRGYLDRVAEGLAKPLKVFMDNAPFHRSREVEGRKEAWRERGLMVAYLPRYSPHLNPMESVWRRVKGFLMPRRHYGSVEELKEAVAQALKALGGVELKILGEGT
>NC_005838.1|WP_081424955.1|89722_89902_+|hypothetical-protein
MEAVAEADAHLKGLLAELEAVATLRQAKYHLDQVGRGRAIAVYRDPATGEPVYRTPVIG
>NC_005838.1|WP_011174454.1|101656_103567_+|hypothetical-protein
MQAPVYLCLLGNDPAPAYLGLKVVEREAGRVAKAVFYSFPAWNEEYGKKRQAFFRLLSEKGVLYEERPLEKGLEEAEAREVWVNLTGGAKYWAVRFLGHWRRPGARVFLVEGHRALEAPRALFLWPREEERSLEAEALTLEEYARLYLEPLGEAWERVSPPGAFPPGAQAARLPGREGGVFVVHRGLPYWYWVRPHLGGEAKEMSRKALSAFSGEAKRLGGQLCLPVVPYHKAHLRSRHPKERENVFARWRAWAREYGVFLVDPGRPLEEEVASLIKGKASKKALPLPQEGPLLLALVSEQAVPLYAAYLHAGPREVYLLTTPEMESRLRWAEAFFRGKGVRVHRSFLSGPWALREVRDLLAPVVEEALRRGHPVHANLNSGTTAMALGLYLALRDGARAHYLDGDRLLLLDGGEAEVPWEEGRPEDLLALRGYRFEEEYPDARPDPGLLALAEEILRRWDEVQTSWEASPLVRRFLKFWKKRFGQAFPPKRLSRLKGLPLEYAVYSHLNAHLAPKGGQARMGGHLVPLGGNEALAPQFTEVDGVFFHRGALWFVECKPTDEGLRERAPIMAELVRSVGGVEARGLMVARRWRGAPPPASPNLVYMALEGGEGVGVYRFPEELEKALSRNPAPRRG
>NC_005838.1|WP_011174453.1|103537_104059_-|hypothetical-protein
MEALWQRTGDPLGDFIRLVLLVEELLERLGAPKEDTLGAKLRSGAAEAFFQSHPEGPALRGRLWRLVELRNAVLHERAEVPSWAFSEGRDLAARLLAAVERQGFYSREEWTARMAFLEAPAPPTPQAFPEVIPPERARSPEAEERPPGAWKTLPFPRRPLAKRALAPPRRRIP
>NC_005838.1|WP_011174452.1|104063_104783_-|hypothetical-protein
MTAWLLSLALNLPFLGGPQEYQILVALGCSAPRHVQNGYREMLAHEVLPRLAEKVTTTQVRLTLAPITGRSYTAPARVLETPNPLSTPRFQLEEAKKTFQKEALRTFDELRKRAAAECSRGTEIIGALKAAGERARKPGRILVLAHGFEQSELMNLYDYRLKLEKREVRQGLLQRVKARLGLPNLKDQEVCIAGITAGNDNNANARLTTSIKAFWEELIQASGGRLVGYGTTPRVCPFL
>NC_005838.1|WP_011174451.1|104751_105717_-|hypothetical-protein
MLNGFRVLRSYWVGRRDGKALSRKHASLAYLTPNPYPEQLKEWFRRWMEGLARRYLAKRAKLEERLALVRHQRKALEKVVGQDEPTPEVFGGYHFRYGLLGLVFLGEAYYNKMAMDTLEMNQLEAFIIGAVATIGLFWLGHAAGNEYRKGNLPLSLILGIPPLLVVILFAALRSSWTQRMAAIHGNPAPSIYGFLALMAVGLLLVSLTFYLGYRSPHEREVLLRRLFLTAQKERRIWERLRGLNRGAERALDHLLAHYRENVAAYWRGFARAWPQWDPAPEFVGHIPPLNRPALPPLDLEAPTDPLTQGSAHDRLAPEPRP
>NC_005838.1|WP_011174450.1|105709_106120_-|hypothetical-protein
MFWRRMGPEEARVRLVLLREGVRQKVGALEARLAKRKAPLEKALKEYRGVLEHLRRLEAEGRYPEAVLRPALAREELRIRYAEGEIARLEEAHRQAVAQLVSRARLKAARLAALAQMEEALDRFFPTPETKEEAHA
>NC_005838.1|WP_011174449.1|106246_108001_+|type-III-B-CRISPR-associated-protein-Cas10/Cmr2
MEHLLAIALGPVQEFIATARRTRDLYAGSRLLSEAAARAAEALAREVGAKNLIFPAPEDEAGLERLAGAGIPNVLLVRVPEGKDPRGLGEQALGAARDYLRERAEEVLGPRRDLLFWREALAQVEDLLEGYYAYLPLEGDYPRARERLMALLAARKNTRDFAPVSWGSPAYKSSLDGARESVLRLPEREADHLRVRLGLRPGEYLAGPDLLKRWWKAGHGFLSTTHMAALPFWEGVRRAGLEAVLKEALEELGGLVGEEARAEVRHPVLRDTPFGEWDVRLLYESRLEEFPSLAEDPGLLEKARDRLRALWRRLSPKVRVPPGAYYALLHADGDRMGETLDGLPSPEAHRRFSNALALGFAAQVKDIVEAHGGGLVYSGGDDVLALLPLHTALMAARALADRFREAMAPFGREGRAPSLSVGLAVVHHLEPLQDALDLARRAEKWAKEGEPKRNALCVAYSPRSGAERLVRGRWDENPPLTRRLLRYADLLRAGEVPSRAAYELLALVREAGEALPGEALVAEALRILGRKEMKRAYREELEAWLRTGEDVRRLAEELILARPFAEALDQAGVPVESREVWDAH
>NC_005838.1|WP_011174448.1|107990_109076_+|type-III-B-CRISPR-module-associated-protein-Cmr3
MLIEPRDPLIVRDGRPFTNSPGARAKSLPFPLPQTLAGAYRTRRALLEGLPLPERAEEVLRWGLRGPLLAEEGEGGWRLLAPRPLDALKLGEALYPLRPLELPQGAGTNLPEGLSPVGLPSPALKEKPAPLPAFWYWESFLEWLLQDAPAGFAPRGHEGPVPETRTHVALDPAAQTAREGFLFQTSGLEFVRGRRRLALVLWPEGPEPEGVFPLGGERRLAFWQKGGPGVPPLPEEVVAGLLRHRAARLVFLTPAFLGEAYLPKGRAFQGASVVAAVVGRPVAVSGWNLKEGKPKPSRRAVPAGSVYFVRFPEAWGEGEVRDWAGKVWFQNLSEEEQDRRDGFGLAALGLWDGKLRRWEEA
>NC_005838.1|WP_011174447.1|109072_110260_+|type-III-B-CRISPR-module-RAMP-protein-Cmr1
MRRAFREAFSPRRKEEGEVLVRRDGARVLAWERTYTLLTPLFGGGVEPREADPVSVVRATAVRGHLRFWWRAVRGWRAGGSLERLWELESALFGHAGEGGASPLSVEVEVLREGEKVGIAQYGRAVQWYLGFPLRGDKEWAPVKEGVAFRLRLRFPEKVGELNFWEELEAALWAWETFGGIGARTRRGFGALLPQGAGVPGEEEIREKLRQYSQKAGWPEGVPHLTPKSFVRVVPLSWKELAERYQAFRQARPGGDPRSPGRSYWPEPDGVRRLTGRHAPHHLPRHPVHKFPRAHFGLPIIFHFKDRGDPPDTTLRLKEADRRASPLLFRPLGEGQKPCVVAVLEGARFPGEKLVLEGKDGRTWDVDPWLTPEEAQKIPVLGGEADPVLAFVKSL
>NC_005838.1|WP_011174446.1|110275_111136_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MSHVALLFLHALSPLHAGTGQGIGAIDLPIAREKATGIPYLPGSSLKGVLRDRASAWDRDTLFAVFGPDTENASEHAGAVQVGDAKLLLLPVRSLYGVFALATSPYLLERFRREALMAGLQPPGVPGLRDPTQVLLAPGSRLLGDGEKVYLEDLDLKAQGEEGVAAWERWLAERTEAPVLGRLAVVHDDLMGFLLETATEVVARIRLDDETKTVAKGALWYEESLPAESLLYALVRADRSFRKGKELRPEGVWGLFRGVLEEGGGVLQLGGKATVGRGLCRVRVGR
>NC_005838.1|WP_011174445.1|111139_111484_+|type-III-B-CRISPR-module-associated-protein-Cmr5
MRTRSQVWAQKAYEKVREAAKGEGRGEYRDMALKLPVLVRQAGLSQALAFVDSRGKEAHKALGNHLAQVLGYRDLRELAEAAREAELLQYLRLTREVLAAAEWFKRFAQALIEE

Crispr_ID: NC_005838_4

• CRISPR_ID: NC_005838_4
• CRISPR_location: 131658-132212
• CRISPR_type: TypeI
• Repeat_type: I-C,III-B
• Spacer_info: 7 spacers
• Cas_protein_info: DinG,cmr5gr11,cmr4gr7,cas3,cas5,cas8c,cas7b

Consensus repeat of NC_005838_4

Consensus_repeat	Method
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	PILER-CR
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CRISPRCasFinder
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CRT

spacers of NC_005838_4

>4.1|131695|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT
CTGGCCGCCTGGCTCTTAATGAGCTGGAGCACCTGGTG
>4.2|131770|34|NC_005838|PILER-CR,CRISPRCasFinder,CRT
GCGCTCTCCGCCTGTAGGTCCAGGCCGAGGACCT
>4.3|131841|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT
ACCCAGTTGCCCCTAACCACCCAATAGAACCACCCATA
>4.4|131916|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT
CCGGGGCGCGCCGGACGATCTCCCGCAGGCCCTCCAC
>4.5|131990|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT
CCCCCCCTAGTGGGTCCTCCACCAGGGCCCCGCCGCA
>4.6|132064|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT
AGGCGGAGCTCGGCGAGGATCTCCTCGTGGTGGCGGCG
>4.7|132139|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT
CCTCTAAGACGGCCTTCTCACCTATGACCTCCTCCGG

CRISPR arrays and Neighbor proteins around NC_005838_4

CRISPR arrays

The CRISPR arrays of NC_005838_4

>merge|NC_005838|4|131658-132212|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGTAACCTGGCCGCCTGGCTCTTAATGAGCTGGAGCACCTGGTGGTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAACGCGCTCTCCGCCTGTAGGTCCAGGCCGAGGACCTGTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAACACCCAGTTGCCCCTAACCACCCAATAGAACCACCCATAGTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAACCCGGGGCGCGCCGGACGATCTCCCGCAGGCCCTCCACGTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAACCCCCCCCTAGTGGGTCCTCCACCAGGGCCCCGCCGCAGTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAACAGGCGGAGCTCGGCGAGGATCTCCTCGTGGTGGCGGCGGTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAACCCTCTAAGACGGCCTTCTCACCTATGACCTCCTCCGGGTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC

>NC_005838|4|4|131658-132212|PILER-CR
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGTAAC	CTGGCCGCCTGGCTCTTAATGAGCTGGAGCACCTGGTG
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	GCGCTCTCCGCCTGTAGGTCCAGGCCGAGGACCT
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	ACCCAGTTGCCCCTAACCACCCAATAGAACCACCCATA
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CCGGGGCGCGCCGGACGATCTCCCGCAGGCCCTCCAC
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CCCCCCCTAGTGGGTCCTCCACCAGGGCCCCGCCGCA
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	AGGCGGAGCTCGGCGAGGATCTCCTCGTGGTGGCGGCG
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CCTCTAAGACGGCCTTCTCACCTATGACCTCCTCCGG
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC

>NC_005838|4|3|131658-132212|CRISPRCasFinder
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGTAAC	CTGGCCGCCTGGCTCTTAATGAGCTGGAGCACCTGGTG
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	GCGCTCTCCGCCTGTAGGTCCAGGCCGAGGACCT
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	ACCCAGTTGCCCCTAACCACCCAATAGAACCACCCATA
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CCGGGGCGCGCCGGACGATCTCCCGCAGGCCCTCCAC
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CCCCCCCTAGTGGGTCCTCCACCAGGGCCCCGCCGCA
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	AGGCGGAGCTCGGCGAGGATCTCCTCGTGGTGGCGGCG
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CCTCTAAGACGGCCTTCTCACCTATGACCTCCTCCGG
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC

>NC_005838|4|3|131658-132212|CRT
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGTAAC	CTGGCCGCCTGGCTCTTAATGAGCTGGAGCACCTGGTG
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	GCGCTCTCCGCCTGTAGGTCCAGGCCGAGGACCT
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	ACCCAGTTGCCCCTAACCACCCAATAGAACCACCCATA
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CCGGGGCGCGCCGGACGATCTCCCGCAGGCCCTCCAC
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CCCCCCCTAGTGGGTCCTCCACCAGGGCCCCGCCGCA
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	AGGCGGAGCTCGGCGAGGATCTCCTCGTGGTGGCGGCG
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	CCTCTAAGACGGCCTTCTCACCTATGACCTCCTCCGG
GTTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005838.1|WP_041443918.1|132414_134598_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl|CDD|350688
NC_005838.1|WP_011174431.1|134607_135297_+|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl|CDD|187782
NC_005838.1|WP_011174436.1|119269_124219_-|RecQ-family-ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl|CDD|223588
NC_005838.1|WP_041443921.1|135280_137044_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	gnl|CDD|273839
NC_005838.1|WP_011174434.1|125671_131059_+|hypothetical-protein	unknown	unknown	gnl|CDD|226973
NC_005838.1|WP_011174427.1|139254_140007_-|LamB/YcsF-family-protein	unknown	unknown	gnl|CDD|377121
NC_005838.1|WP_148187591.1|143692_144850_+|ATP-binding-protein	unknown	unknown	gnl|CDD|224292
NC_005838.1|WP_041443928.1|145795_146056_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	unknown	unknown	gnl|CDD|376852
NC_005838.1|WP_041443916.1|131286_131565_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_162467451.1|145010_145148_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_005838.1|WP_011174439.1|116352_117897_-|transcription-antiterminator-BglG	unknown	unknown	gnl|CDD|223153
NC_005838.1|WP_011174438.1|117872_118415_-|hypothetical-protein	unknown	unknown	gnl|CDD|130902
NC_005838.1|WP_011174442.1|113285_114998_+|aldehyde-ferredoxin-oxidoreductase	unknown	unknown	gnl|CDD|225277
NC_005838.1|WP_011174446.1|110275_111136_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	gnl|CDD|274210
NC_005838.1|WP_011174445.1|111139_111484_+|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	gnl|CDD|378242
NC_005838.1|WP_011174437.1|118411_119251_-|hypothetical-protein	unknown	unknown	gnl|CDD|274008
NC_005838.1|WP_011174422.1|145382_145799_-|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350313
NC_005838.1|WP_011174441.1|115000_115777_-|CPBP-family-intramembrane-metalloprotease	unknown	unknown	gnl|CDD|376806
NC_005838.1|WP_011174426.1|140034_143163_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl|CDD|239168

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	2.6e-98	323.5	0.0
NC_005838.1|WP_041443918.1|132414_134598_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	9.8e-47	154.3	0.0
NC_005838.1|WP_011174436.1|119269_124219_-|RecQ-family-ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	4.2e-78	257.9	5.6
NC_005838.1|WP_041443921.1|135280_137044_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	1.4e-160	530.3	0.0
NC_005838.1|WP_011174446.1|110275_111136_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	cmr4gr7	cd09682_cmr4gr7_CAS-III-B	2.3e-86	284.6	0.0
NC_005838.1|WP_011174445.1|111139_111484_+|type-III-B-CRISPR-module-associated-protein-Cmr5	cmr5gr11	cd09749_cmr5gr11_CAS-III-B	9.5e-33	107.9	2.7
NC_005838.1|WP_011174431.1|134607_135297_+|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	3.4e-73	240.4	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005838.1|WP_041443918.1|132414_134598_+|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	8.23968e-53
NC_005838.1|WP_011174436.1|119269_124219_-|RecQ-family-ATP-dependent-DNA-helicase	gnl|CDD|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	1.61084e-101
NC_005838.1|WP_041443921.1|135280_137044_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl|CDD|273839	TIGR01863, CRISPR-associated_protein_CT1133_family, CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein that tends to be found near CRISPR repeats of the DVULG subtype of CRISPR/Cas locus. We designate this family Csd1 (CRISPR/Cas Subtype DVULG protein 1). The species range for this subtype, so far, is exclusively bacterial and mesophilic, although CRISPR loci in general are particularly common among archaea and thermophilic bacteria. In a few species (Xanthomonas axonopodis pv. citri str. 306 and Streptococcus mutans UA159), homology to this protein family is split across two tandem genes; the trusted cutoff to this family is set low enough to capture at least the longer of the two.	0
NC_005838.1|WP_011174434.1|125671_131059_+|hypothetical-protein	gnl|CDD|226973	COG4625, COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown].	5.29303e-07
NC_005838.1|WP_011174427.1|139254_140007_-|LamB/YcsF-family-protein	gnl|CDD|377121	pfam03746, LamB_YcsF, LamB/YcsF family. This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are subject to carbon and nitrogen metabolite repression. The exact molecular function of the proteins in this family is unknown.	6.89036e-140
NC_005838.1|WP_148187591.1|143692_144850_+|ATP-binding-protein	gnl|CDD|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	3.82929e-50
NC_005838.1|WP_041443928.1|145795_146056_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	gnl|CDD|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	1.14207e-11
NC_005838.1|WP_011174437.1|118411_119251_-|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.04221e-06
NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.7047e-87
NC_005838.1|WP_011174439.1|116352_117897_-|transcription-antiterminator-BglG	gnl|CDD|223153	COG0075, COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism].	0.00458444
NC_005838.1|WP_011174438.1|117872_118415_-|hypothetical-protein	gnl|CDD|130902	TIGR01843, Hemolysin_secretion_protein_D_plasmid, type I secretion membrane fusion protein, HlyD family. Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking].	3.93849e-05
NC_005838.1|WP_011174442.1|113285_114998_+|aldehyde-ferredoxin-oxidoreductase	gnl|CDD|225277	COG2414, COG2414, Aldehyde:ferredoxin oxidoreductase [Energy production and conversion].	4.56208e-99
NC_005838.1|WP_011174446.1|110275_111136_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4	gnl|CDD|274210	TIGR02580, putative_CRISPR-associated_protein, CRISPR type III-B/RAMP module RAMP protein Cmr4. This model represents a CRISPR-associated protein from the family that includes TM1792 of Thermotoga maritima. This family is part of the broad RAMP superfamily (pfam03787) collection of CRISPR-associated proteins. It is the fourth of a recurring set of six proteins, four of are in the RAMP superfamily, that we designate the CRISPR RAMP module.	4.68724e-107
NC_005838.1|WP_011174445.1|111139_111484_+|type-III-B-CRISPR-module-associated-protein-Cmr5	gnl|CDD|378242	pfam09701, Cas_Cmr5, CRISPR-associated protein (Cas_Cmr5). CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	2.02437e-32
NC_005838.1|WP_011174431.1|134607_135297_+|type-I-C-CRISPR-associated-protein-Cas5	gnl|CDD|187782	cd09651, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	2.33328e-90
NC_005838.1|WP_011174422.1|145382_145799_-|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350313	cd18746, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	6.18974e-59
NC_005838.1|WP_011174441.1|115000_115777_-|CPBP-family-intramembrane-metalloprotease	gnl|CDD|376806	pfam02517, Abi, CAAX protease self-immunity. Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases). The family contains the CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin. Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity.	1.69022e-06
NC_005838.1|WP_011174426.1|140034_143163_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl|CDD|239168	cd02767, MopB_ydeP, The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins.	0

Protein sequences

>NC_005838.1|WP_041443916.1|131286_131565_+|hypothetical-protein
MLEYCVAYRNLGTAPVSQFVLTDPVPFFTDPLPSVPDYGGKAIRWSHGSATLYLTASQGDDAGEVSGGVVRVEVGNVGPGEAGEVCYRVQIR
>NC_005838.1|WP_011174434.1|125671_131059_+|hypothetical-protein
MKRVFALVLLLLPALAQPVARELKATVVGDGVGWETHALRIWLVIPEKGRVRLDLFSPGFDPTDYRSALLGKPELGDERYDGGKGELKATFRLYRDGKPLREMAFGVEPHRWVPFFEGEMEAGVYLFESELLGNGKNTFVLRVEAPSFKLSLDPKPQLILDVFTQTTTLRLLPDERGRVWVEPLGVYSEGPLEVAFYDEDGPEELRARVRYEDGSVEERPVSGDREWTTYTKRPGLALFGFTQPPTARQHSNTVAFRVGACTSLENGVLKAIPPGEARARVVDEEGKPLPVPVEEKDRVFRPLLPEGASLLRVEARGAVFVQEGWAEVGCPGGEVTFVVRLPKPPAPERPPQGEVRFRVAVALPGGDLPAKATLRLGDLEAPVDGERTLALPRGRYPLAVLAEGARVEAPQEVEVLPGKRQEVLVRLLPEVALSLAPKEVYLRVGEEGEVVLTATTPYPGLLPAELSLELPEGLTPLGASRAQGPLTKDRPFQLRVRFLAEKEGTYALSGLLAPWGLKAEGRAVVVRPATFRLVKEALTPEVEAGGVARFRVTVVNEGDEEGRALLVDRFLGTEERREVFLKAKEGRSYEFAFPVPLEAQGTLVNRAELSTGEKAEAGVRVLRPKAHLERSLPHRVYLPGEEVVLSFLVENRGEAPMRYVLEDACPDWLSPLEPARFEGYLKPGEEALHAYRARVLLGPEAEGACAATLRTPTETLRAEVALKRRPLLLEKEADPPRLLEGGQGVFRLRVRNPADHRVEVELRDIPGKGLGMDPWSERVALEAGEERVFTLPFRAEAVGELENGLSAFLGETPAAFPVKAKVAVLPVLVPERTSVVRLPFRVEGEGDALLLGFKPPEGAEYSPGSARLDGRPVEEPRVLPDGTLVWRLPFAREGLLTLTLLHTRALPPLPEPALTLLRLDRELPLKGGLRLRDYEGAKPLSAKRKGPIREPMDGAIVQQEAVALRIEAPLGPIAVRVNGLEVEGRLLGEAQYDEERKVQRLAYYGVPLRPGRNVIEVEGPGFYDKVEVFRPGPPKDLVLEPVRLRADGRTPLEFRLKAVDGMGLPTGFGLATLEADPEPIAPDASLLEPGYQVLLRDGVGTVMLKPLLTPKEVRLRARFNDLEKTFRLFAGGSQEPLWLAQGSVGVAYDPEEGRPRLFGLARGYVEAPLEGGFLQGALDTTGGLSQTPEAGFFPITGSGEEARRPLASDDPVALRYTTPEYTLAYERGPLAPGLGEATALRLATRGDARVEAFLALLPKGSVREEIVPDGTAFYRLSGSPAPGSLRLFLVEGGRTRALEAGVDYTYDFLSGEIVLARPLAPFTPEFAPVRLVAEYAPLSAPREELALGARAAYEAGPWRFGLGGYLRLDLQGFASQGYALGASLAYGEGGSEVGLEAAFAGKWRFGLSAALSEGPLEARGNLAYEEGGEVQGAFRAAYDLGPGAVALEHTTPGRTGLVYEAKLARGFRFGLGAGYAWREGGLYLLGRAAYQEGRARFGLSHAYLLSGGQETRLDLLWPLGEALEAEGSLAYLWGEGLQGAFGLRQRLGSANLALSYQLPTASGEGNRARFGLEAPLPLTENLSANLGLYALYAFSGGQGELGGSLGLRYAREGLVATFGVEGALGPKLTLRGGAAGSLDPENTLGLDFALSLLPEAKGRFSLAYALRASDLSLLTYHRYATETGLLEGQLAAAYAPFPAFSVRPAFGYRYPFPDPEGATYALGLYATLFPTELLGLGGGASYTFQPATGASDLSFSVEGTLRLSPLWLSLGYQFGPSLFAPEGVYLRLDVFGGSR
>NC_005838.1|WP_011174436.1|119269_124219_-|RecQ-family-ATP-dependent-DNA-helicase
MAFGVSHPVALDLEATSTDPSEAEVLEVAAVDGEGRVFHRYLATQRPLPPDHEVFQLTGIPYEEYEAKKVAPKEALEELLAFLGGRPLLGHNLLRYDLPLLQRHLEEAGLPRWQGEALDTLRLAHLLFPTPPGGLEGYRLGDLYAFLLGRPLEGAHRALNDAQATLAVFHRLLDRGRRALAQHPGLVRAWRELGLPEGHLFPEDEGLIKDLLAREADVEAFFVEKEGRPFPAPTDLGPDLLPKPRPAQRRMFQLVEEALSREEILLLEAPTGTGKTKGYLYPVLHQRKPTWVATHTKVLQAQAMEELRAVAQKGYQVRAALVKSPQDTLCPDRLLEAFLREARSGKPGEDVGAAIAVLLHYAAQRGHDLEALPAYWHFLEGFREVRGRVGTNPDRCRRECPFASACAYQAILRRREEAQILVTNQAYLLHSLLGEKALPEARPALVLDEAHHLEDVATEALTLKVDGEGLRHLLEALANPSKRSGLLQERDYLKSLEDDLRASAETLAEEAVPKALEALKAYSERMERFLKRRGVGSPEHGLTLPLEPSWTRDEEYPLLDREERHLIQSLEALAKGLEGLLDAHPPPWPLLLREIRPLLQELRQAIRLFLRRKRVLKGEADEALHLTRLDPVTGTWSHLAEPIEVAAELEEKLWPAFRGVVLTSATLAVPTETDPEGFAFLQRALGLPPQARAERLPPSLPYHRAHLLVPRHLPEARESTLPRFQRLLHRELRLVLGQVPRTLTLFTSLSRLEAAKKALEDLPHLRAPLTRREREDTVRFARSNPTEPLAALGSRSFMEGVDLPHLRVVNLERLPFPYPSPLLKRRMALAYERGLDPWEDYYLPKAVLSFVQAFGRLIRDDRQVAGDGAFILWDKKLLHADYQELFYRALPDGVAHHFPGDRQAFYRKLEEILGLAFPGAEEELSEEAWAKVKAILAEAGLGPLERARRLAEEVHGVLVDEARWAKQREAVRAALEGRHLLALLPTGFGKSLAFQIPAWMSPGLTLVISPLVALMKDQVDRLQELGLPALALHGLMSWGEQASVLDEVRAGQVRLLYLAPERINRSEAVRKALRELREAGKLVRVVFDEAHCLLEWGYDFRPDYLKVLEWLRELGLPMSFFTATLTPEERARLKEVAGIPEAVEVLPETFHRPNLRFVVRQAPGEVGKFDRLAQALLWVEKTGGSAIVYATSRAETERLAWALDRLFPSLGVEAYHAGLGPVLRKEVQERFMRGESRVVVATTAFGMGVDKPDVRLVVHWRPPLSLEEYAQQAGRAGRDGKEAYALLLYTHGDWGFLRWMVGLGQRGTERLEALAERLLARLPFRGYRKELLELLMTEGAEEAAEEEASDLEAGPALSGEDLERLLLGMEQAGLIRYEYLPGKASLYLSPEQWEAFARTPGLAERLVRAGYRPGSRQNVLDLSKLPREEAEDLDRYLYQAYRKGEAILYRYREPLLLVERMDPGKIVRWRASLEASRARALERLGRVQAYATQGRCRALVLLSHLNGERRRCGTCDVCAQDGGPWEAMENFHEEELLRAYKPLDTLLAFFRWAEDHYPQKPLLGRKATLMALRGKAWTGNGPLHRRYLENRFFGHLSFLKPKELEQAFREALERGYLEQKGSWQGHPLFGLTDHGRQRLRKGARGKEAR
>NC_005838.1|WP_011174437.1|118411_119251_-|hypothetical-protein
MDPSKAFRIPSLEELPPRETPLRPTTPPLPEFTPTGEGALPALDPKAKATPAPPPERGPLSLQGELKRTRDQLERLKVKLAQAEKARAEAVKERDKARQEAAVLRKQVEALTASHAAMRQALEKAQEDLKILQEELETLKKEKGELETLRKERDELFARAARWEKAETLRERLQEPFPIEAFFRMLFVPYSELGPGPEVRLLALIEGYRALLQGKEHPMLSRTNRELLSGEPEGIVLLGVERLLLDLAESPLPRWLKTHAWLAEAFLTREKLSSPREEA
>NC_005838.1|WP_011174438.1|117872_118415_-|hypothetical-protein
MTWEEEKKALEARFREDLAWYEREWEACRRKLEEERQEWNATRKRLLNELSQSSRKVWELKKRLEALQGLEERYSALEREVRGLRRKLAALDRPAIGRRYLEALREDLALWDELLLAEAERLQTRGLEGFLQELWAKREAAFRHWQAGEDVDFATVRTALVLEWAIWTWLEAGWNPGRTP
>NC_005838.1|WP_011174439.1|116352_117897_-|transcription-antiterminator-BglG
MEPWAHAVNLHRAVEAALEAQNLAHLQVRREDVEGAKPLVRALWRGEWRADPLAKSREGVVPGYLLLGFLGGHFFDRDLPENDLAFWPEFHRALGLNQGQPTPKQRDKLWKVLEGLPGTKAFLRFHADGKRDFVGTLKALFGARTLRLKEILDHLRLYRDEAKLQEEALGPYASLVRGLKEALDLLAEEALDAAEQEDVEALVARLEALGFYAEEPHPLRFLFHRSPKAFAELYAEWRGEKKATPLRHPQVRVEVLQGKEVLERVLPQIRREVLVEGALVYGQVRLKSGLFRGFCWRPRLDTEGNPIPEEVAVPLGEGQVVLRLHHRAWGVRFLDERGQVCPEWRPPEPLEVRPLVDEGTPVRFLLEGGGDPVERLEDLPLELGLPEDALVVEALVFGSREHGEWRPLGRLPVRLEARLEERLSETALELEVFPRGPLETVWLAPAGPKQTFPEGRACIPRGLWPVKILVKAWGRAWEILVPPKGWPEKAWRRGLGLPAVGANKLGNNPSRFHL
>NC_005838.1|WP_011174441.1|115000_115777_-|CPBP-family-intramembrane-metalloprotease
MRALYWTFGLSWSLALAAYLLGLRPQSPAYLAFAVLYMWVPGLVALALARKEGVGLPLAFRPNRFWLFAWLFPVALTLLSLPLSLPFAPWKGLAWALPEGVPRIPEAALWALVLLQGLFAGATVNLLAALGEELFWRGYLWEKLRKRGFWPASLEIGFYWGLWHAPLVLLFGHNYPDHRLLGVGMMVLFTLALTPALLYARERGGSLWAPALFHGTLNAVAGLSLLAVERTHDLLVGVVGLPGLFLLALFNLWLRRRV
>NC_005838.1|WP_011174442.1|113285_114998_+|aldehyde-ferredoxin-oxidoreductase
MWRSLRVDLKARKAYWQEVPPEEVAFGGRYRTGQVLLEREAYRVDPLSPENPLVFAVGPLAGTGFSNANRTSVGTRSPLTLGIKEANGGGTFGYALGQLRLAHLVLEGESPEWVVLRLTRSGEVHFDPAQDLLGLGNFEAARRLFAAYGQRIAFALLGPVGEYLGLLSGIAFSDIDGRPSRLAARGGVGAVMGRKRVKAIVVEVLGKAEVVDKPKVAEAIRRYAKLLREDPLVMQFYNAIGTMGMADFQNAFGGLPVRNFREGRLAPPEAFRMGGQYIAPLNKSRGGKHTHACMPGCVIQCSNVIVDERGEEVVSPLEYETIGLLGTNCGLNDPDQLARLNRLANDLGIDTIETGATLALLMEKGLAPWGDYAFMEAKLKALYTPSEEARFLAQGTARVGEALGLRRVPVIKRQAISAYDPRVVEATGITMMVTAQGADHTAGNAPRLETRAMKAEEILEASYTAQVNAAANDSLGLCVFGGSVTNKEVAFVVESVNAALGTDFSPELWRKLGEGVLRLEHRFNHLAGFTHEDDRLPAFFYEEPVPPKGYTARFHPEDLGPLYERLHQEP
>NC_005838.1|WP_011174445.1|111139_111484_+|type-III-B-CRISPR-module-associated-protein-Cmr5
MRTRSQVWAQKAYEKVREAAKGEGRGEYRDMALKLPVLVRQAGLSQALAFVDSRGKEAHKALGNHLAQVLGYRDLRELAEAAREAELLQYLRLTREVLAAAEWFKRFAQALIEE
>NC_005838.1|WP_011174446.1|110275_111136_+|type-III-B-CRISPR-module-RAMP-protein-Cmr4
MSHVALLFLHALSPLHAGTGQGIGAIDLPIAREKATGIPYLPGSSLKGVLRDRASAWDRDTLFAVFGPDTENASEHAGAVQVGDAKLLLLPVRSLYGVFALATSPYLLERFRREALMAGLQPPGVPGLRDPTQVLLAPGSRLLGDGEKVYLEDLDLKAQGEEGVAAWERWLAERTEAPVLGRLAVVHDDLMGFLLETATEVVARIRLDDETKTVAKGALWYEESLPAESLLYALVRADRSFRKGKELRPEGVWGLFRGVLEEGGGVLQLGGKATVGRGLCRVRVGR
>NC_005838.1|WP_041443918.1|132414_134598_+|CRISPR-associated-helicase/endonuclease-Cas3
MDPKAHTPNPQGAWHALKDHLEAVSRLAGGFAQHFGTPSLGQALALLHDLGKATRDFQAYLKVAAEGKRTNSVPHAVWGAALAYVALGSGQHEGWEAFGLPVMGHHAGLPKRGEAASKLAQALKEEPFKEVAAFLRSSELRTRLEGLLNEALKEVRSKTAGDPLRLDFLVRMAFSALVDADYLDTEAHFDPSVARLRQEGYSLEKLWARFHRDQEALLQRVRPSLVNSVRREVYEACLQAAELSPGLFRLTVPTGGGKTRSGLAFALRHALKHGLRRVVVAIPYTSIIDQTAQVYREILGEEAVLEHHSAYEPPLGEEQEENVLRQRLATENWDAPLVVTTTVQLFESLFSNRPSKMRKVHRLARSVILLDEVQTLPPELLKPTLEALRLLATPVEEGGYGATVVLSTATQPTFEVVPTFQGLPVREIVPDYPRHFARLQRVVYERRPKPLSWEELARELQARPQVMVVLNTRKDALALLEALGEDPHAYHLSTLLCPAHRREVLEEVRRRLREGAPVRLISTQVVEAGVDLDFPEVWRAIGPLDRVVQAAGRCNREGRLDKGKVVLFWPEEGTTPRGPYRVGVEKARLLLEEHPPERLHDPGLYQAYFKELFTTVKTDKGIQEHRKDLDYPEVARRYRLIQEDTVSVVVPYGEGLARLEAFQKAPSLQNWRRLQAYVVGLFRNQVRERRGFLEAVPGFQDLYVWRGSYDPRRGLVEEYADPSDLIV
>NC_005838.1|WP_011174431.1|134607_135297_+|type-I-C-CRISPR-associated-protein-Cas5
MARLKVKVWGEYACFSRPEFKVERVSYPVPTPSAARGLLEAIFWKPEFRYEVRRIGVLRLGTPFALLRNEVGNRMGAKPFFVEDARQQRTSLVLKDVAYLVEADMVLRPHATDPLPKYLEQFERRLKKGQYHHTPYLGTREFPAYFSPPDGEVPDGGLNLDLGPMLFDLAFVEDPGRPELTFKRPGRGEVQGYALPLFFHARIREGWLEVPAEKYQELYRLEEGHAKGA
>NC_005838.1|WP_041443921.1|135280_137044_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MLRELKEAFHRFRKEGVLLPLAYKRKSVAWFIRLEGGKARLEGPYGKREGVEPIPAPDRQRSGKASEANLKPYLLVDDARYVLGLFEEGREDEAALLHKGFKELTEKAWRETQSPHVKVVLDLLSSPELGDLREEFRQKGGKPRDLLAFKVHGVLPTELEEVQAFWARHLAEEIQGGKGYCALCGTLGPVLRIFPREVVVLGQKCQLVSFNQKAFESFGKEQAANAPLCFTCASQVVDTLDYLIRSERHSRPLYREEEGGLRNQLAVFWLSEKVEVPLETPVDLETILGAVLSGALVHSPTPPADLTQLQELLATPWTGKAWPLNLDETRFHLAVLSANKGRLVVREWLAVSLSRLKETLGRFLEGTRLVRPWGEAPQPVPVGALVQALGDGNPGLVRGLLRTAYLGTPPPHALSLAIHLLRNPKTLTPEEREGWGRLHALVAALKLWLFYGKEEAKRMAELDKERKNPAYLSGRLLAVLEEAQKRASSYTLRRTLVDRFYGAASTTPAATFGVLLRLSTTAHLPKVGQELNQAVEEILSRLDEAGGFPRTLNLVGQAEFALGFYHQRAHFRANRAGKKGESAQGGS
>NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MMSARYLDPKKRHEFVFLFDVRDGNPNGDPDAGNLPRVDPETMHGLVTDVALKRKIRDYIALTREGKPRFAIFVQSRVALNRLILEGFQEAGIEPVSLQLAEEQMANESLLEHLDGLAEAGFSREGGTLYYSGQATTEKEIAKLLMGEEEAVAPFKKELEKLAKELAKAVKGRKITEEDRERAQAKLLERFFDIRMFGAVLSTGLNAGQVRGPVQLTFARSLDPIAPLEVSITRVAITREEDRARKETEMGRKPLVPYGLYRAHGFFNPFLAAKTGVQPEDLEALWDALQHLFELDRSAARGEMTVRGLAVFSHEDAKGNAPAHRLFGLIRVERREGVEAPRSFADYRVRAPKEGSLEAHGFPGVHLAWLVRPEGLEDLPPHVG
>NC_005838.1|WP_011174427.1|139254_140007_-|LamB/YcsF-family-protein
MKVDLNADAGESYGAFAYGHDREIFPLVTSANLACGFHGGSPGRILEAVRLAKAHGVAVGAHPGFPDLVGFGRREMALSPEEVYADVLYQIGALSAFLKAEGLPLHHVKPHGALYLKACRDRETARAIALAVKAFDPGLPLVVLPGTVYEEEARKAGLRVVLEAFPERAYLRNGQLAPRSMPGSWITDPEEAARRALRMVLEGKVEALDGGEVAVRAETLCIHGDNPNAPEVARAVREALEQAGVEVRAF
>NC_005838.1|WP_011174426.1|140034_143163_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MAWLNPFWSSPKAYVRPPKRGLAPELWASRIPFTHLENFYEVFRALWENRDNLPYAWRILKDGVCDGCALGTSGLEDWTLHGVHLCNVRLRLLRLNTLPPLDPKVLEDVEALKGRKSRELRRLGRLPYPMLRRKGERGFRRVSWDEALGLAAEYLRRHLPEGAFFYLTSRGVPNETYYVVQKAVRALGCNHVDNAARICHSPSTVVLKEALGVAATTCSYTDLIGTDLVVFLGSNVANNQPVMMKYLYHAKKAGTKVAVVNPYREPGMERYFVPSDLESALFGTRIADRFFQILPGGDIAFLHGAAKWMLEEGWVDPGFIRAHTAGFEAYKALLEAIPFAELEKAAGVSREEMRAFAEMVGRAERAVFVWGMGITQHTHGEDNVRAIVNLALLKGFVGREGCGLMPIRGHSGVQGGAEMGAYATAFPGGLPVNPENARRLAELWGFPVPDRPGLTTPEALDRALEGRLGVLWAIGGDFREVMPDPEAVEEALRRVPLRVHQDIVLSSQMLLEPGECVLLLPATTRYEVPGGVTETSTERRVIFSPEIPGPRPPEARPEWEVFQELVHRLRPELKDRFRFASTAEVREEIARVIPLYEGIQRLKAKGDQFQYGGRHLCEGWRFPTPDGKAHFRPVPPAPKGGPRGGLPRGHPPGEAVQLHRPRGPGPPHRGLPGRGLHEPQGRRPPGPEAWGSGGAGKRLRPLRRPGLPGGGQRGHPGGPLARGERPGRPQGPLPPGPHPGLQGGPRPPAAGGGGGPFPAPAMRGKARVRVARLEGGRWREVRDEVAAEAPLEIRLRYRDEVASLGVVLRTPGQDAELAAGLLYTEGLLQDPKEVLAIAPCADGSLPPEAREGVIQVFLRHPLPPPPKRHLALTAACGACGREALPDLGKLGLSPPPPLAVDPDLLLALPERLGEAQRLFRATGGLHAAALFDREGRLVALREDVGRHNALDKLIGWAFLQGKLPLHDHILLVSGRAGYELLVKAVAAGIPVFCAVSAPTSLAVALAQAYGLTLVGFLRPGRMNVYAGRERVGPPRGLPNPCG
>NC_005838.1|WP_148187591.1|143692_144850_+|ATP-binding-protein
MAQEVAPPTPKGKRGRRAWKRCSSRSSPVFTSTTAAQLDPQGFLSGLQGRVVLDEVQRAPGLFLPLKALVDRDRRPGRFLLTGSANVLALPRAAEHLVGRMALFTLWPLSQGELEGRKEGFLSALFAEEVPPVQGEGRWPLERLLRGGYPEAVRLPPERRGAWFRDYLATVLAREVRELSQVERLGELPRLYALLATRPAQLLNWAELSRASSLPATTLKRYFALLEALYLVRTLPPWQANLGKRLTKSPKVLPTDPGLALHAAGLDGARLEGDPILLGKYLEAFVAMEVVKQAGYAGVAVEVFHYRSHSGEEVDLVLEGPGGKVVGVEVKARGSLRPEDLRGLKSLAQALGPRFHRGVVLYLGRETVPFAKDLYALPLEALWRL
>NC_005838.1|WP_162467451.1|145010_145148_+|hypothetical-protein
MEEALRLVQGEPAAEKALESLLCGVEVPLVAALLLGKLAGPGSGA
>NC_005838.1|WP_011174422.1|145382_145799_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MSYLLDTNVVSEAAKQRPHPKVLAWLSETPLGQAYLSALTLGELVQGVVRAPEARKPGLERWLEGLKQRFAGRILPLDAEVMETWGLLTGEALREGRPLSPLDALLAATALRHGLVLVTRNVAHFRGLPLRLLNPWEE
>NC_005838.1|WP_041443928.1|145795_146056_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin
MGRVWQLQEAKARFSEVVERALKGEPQTVTRRGRPVVVVVDWATYTRLRGEEASLWEALRAPEPLSEEEAETLFTREAAGYREVGF

Crispr_ID: NC_005838_5

• CRISPR_ID: NC_005838_5
• CRISPR_location: 138645-139200
• CRISPR_type: TypeI
• Repeat_type: I-C,III-B
• Spacer_info: 7 spacers
• Cas_protein_info: cas7b,cas8c,cas5,cas3,DinG

Consensus repeat of NC_005838_5

Consensus_repeat	Method
TTTCAATCCTCACCGGCCCTTTCGGGCCGGTGCAAC	PILER-CR
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAAC	CRISPRCasFinder
CGGCCCGAAAGGGCCGGTGAGGATTGAAAC	CRT

spacers of NC_005838_5

>5.1|138681|35|NC_005838|PILER-CR
CCCCGCGCACCCCTCCACGGGGCATAGCAGGTCAT
>5.2|138752|43|NC_005838|PILER-CR
CGGGGCGGGCCGCCATATCTGTACCCGCTCTAGAGCAACTGGA
>5.3|138831|36|NC_005838|PILER-CR
CCGGGAGGAGGCGCTGGAGGTGCGGAGCTACGAGGC
>5.4|138903|39|NC_005838|PILER-CR
CCCCTCAGGGTCCGTTACTTCCACAAAAGTTTTAAAGTG
>5.5|138978|40|NC_005838|PILER-CR
CGCACAGCTTTCGGACGGTGGCTGGCGAAACCCCCAACTC
>5.6|139054|40|NC_005838|PILER-CR
TATGCCCAAGAGGTTGAGCACGCTGCACCTCCTTGCCGAT
>5.7|139130|34|NC_005838|PILER-CR
CCCGCCCGGTCCCTGGAGCACCAGCCTGTCCCAC
>5.8|138682|34|NC_005838|CRISPRCasFinder
CCCGCGCACCCCTCCACGGGGCATAGCAGGTCAT
>5.9|138753|42|NC_005838|CRISPRCasFinder
GGGGCGGGCCGCCATATCTGTACCCGCTCTAGAGCAACTGGA
>5.10|138832|35|NC_005838|CRISPRCasFinder
CGGGAGGAGGCGCTGGAGGTGCGGAGCTACGAGGC
>5.11|138904|38|NC_005838|CRISPRCasFinder
CCCTCAGGGTCCGTTACTTCCACAAAAGTTTTAAAGTG
>5.12|138979|39|NC_005838|CRISPRCasFinder
GCACAGCTTTCGGACGGTGGCTGGCGAAACCCCCAACTC
>5.13|139055|39|NC_005838|CRISPRCasFinder
ATGCCCAAGAGGTTGAGCACGCTGCACCTCCTTGCCGAT
>5.14|139131|33|NC_005838|CRISPRCasFinder
CCGCCCGGTCCCTGGAGCACCAGCCTGTCCCAC
>5.15|138682|41|NC_005838|CRT
CCCGCGCACCCCTCCACGGGGCATAGCAGGTCATGTTGCAT
>5.16|138753|49|NC_005838|CRT
GGGGCGGGCCGCCATATCTGTACCCGCTCTAGAGCAACTGGAGTTGCAT
>5.17|138832|42|NC_005838|CRT
CGGGAGGAGGCGCTGGAGGTGCGGAGCTACGAGGCGTTGCAC
>5.18|138904|45|NC_005838|CRT
CCCTCAGGGTCCGTTACTTCCACAAAAGTTTTAAAGTGGTTGCAC
>5.19|138979|46|NC_005838|CRT
GCACAGCTTTCGGACGGTGGCTGGCGAAACCCCCAACTCGTTGCAC
>5.20|139055|46|NC_005838|CRT
ATGCCCAAGAGGTTGAGCACGCTGCACCTCCTTGCCGATGTTGCAC
>5.21|139131|40|NC_005838|CRT
CCGCCCGGTCCCTGGAGCACCAGCCTGTCCCACGTTGCAC

CRISPR arrays and Neighbor proteins around NC_005838_5

CRISPR arrays

The CRISPR arrays of NC_005838_5

>merge|NC_005838|5|138645-139200|PILER-CR,CRISPRCasFinder,CRT
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAACCCCGCGCACCCCTCCACGGGGCATAGCAGGTCATGTTGCATCGGCCCGAAAGGGCCGGTGAGGATTGAAACGGGGCGGGCCGCCATATCTGTACCCGCTCTAGAGCAACTGGAGTTGCATCGGCCCGAAAGGGCCGGTGAGGATTGAAACCGGGAGGAGGCGCTGGAGGTGCGGAGCTACGAGGCGTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAACCCCTCAGGGTCCGTTACTTCCACAAAAGTTTTAAAGTGGTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAACGCACAGCTTTCGGACGGTGGCTGGCGAAACCCCCAACTCGTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAATATGCCCAAGAGGTTGAGCACGCTGCACCTCCTTGCCGATGTTGCACCGGCCTGAAAGGGCCGGTGAGGATTGAAACCCGCCCGGTCCCTGGAGCACCAGCCTGTCCCACGTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAAC

>NC_005838|5|5|138645-139199|PILER-CR
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAA	CCCCGCGCACCCCTCCACGGGGCATAGCAGGTCAT
GTTGCATCGGCCCGAAAGGGCCGGTGAGGATTGAAA	CGGGGCGGGCCGCCATATCTGTACCCGCTCTAGAGCAACTGGA
GTTGCATCGGCCCGAAAGGGCCGGTGAGGATTGAAA	CCGGGAGGAGGCGCTGGAGGTGCGGAGCTACGAGGC
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAA	CCCCTCAGGGTCCGTTACTTCCACAAAAGTTTTAAAGTG
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAA	CGCACAGCTTTCGGACGGTGGCTGGCGAAACCCCCAACTC
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAA	TATGCCCAAGAGGTTGAGCACGCTGCACCTCCTTGCCGAT
GTTGCACCGGCCTGAAAGGGCCGGTGAGGATTGAAA	CCCGCCCGGTCCCTGGAGCACCAGCCTGTCCCAC
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAA

>NC_005838|5|4|138645-139200|CRISPRCasFinder
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAAC	CCCGCGCACCCCTCCACGGGGCATAGCAGGTCAT
GTTGCATCGGCCCGAAAGGGCCGGTGAGGATTGAAAC	GGGGCGGGCCGCCATATCTGTACCCGCTCTAGAGCAACTGGA
GTTGCATCGGCCCGAAAGGGCCGGTGAGGATTGAAAC	CGGGAGGAGGCGCTGGAGGTGCGGAGCTACGAGGC
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAAC	CCCTCAGGGTCCGTTACTTCCACAAAAGTTTTAAAGTG
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAAC	GCACAGCTTTCGGACGGTGGCTGGCGAAACCCCCAACTC
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAAT	ATGCCCAAGAGGTTGAGCACGCTGCACCTCCTTGCCGAT
GTTGCACCGGCCTGAAAGGGCCGGTGAGGATTGAAAC	CCGCCCGGTCCCTGGAGCACCAGCCTGTCCCAC
GTTGCACCGGCCCGAAAGGGCCGGTGAGGATTGAAAC

>NC_005838|5|4|138652-139200|CRT
CGGCCCGAAAGGGCCGGTGAGGATTGAAAC	CCCGCGCACCCCTCCACGGGGCATAGCAGGTCATGTTGCAT
CGGCCCGAAAGGGCCGGTGAGGATTGAAAC	GGGGCGGGCCGCCATATCTGTACCCGCTCTAGAGCAACTGGAGTTGCAT
CGGCCCGAAAGGGCCGGTGAGGATTGAAAC	CGGGAGGAGGCGCTGGAGGTGCGGAGCTACGAGGCGTTGCAC
CGGCCCGAAAGGGCCGGTGAGGATTGAAAC	CCCTCAGGGTCCGTTACTTCCACAAAAGTTTTAAAGTGGTTGCAC
CGGCCCGAAAGGGCCGGTGAGGATTGAAAC	GCACAGCTTTCGGACGGTGGCTGGCGAAACCCCCAACTCGTTGCAC
CGGCCCGAAAGGGCCGGTGAGGATTGAAAT	ATGCCCAAGAGGTTGAGCACGCTGCACCTCCTTGCCGATGTTGCAC
CGGCCTGAAAGGGCCGGTGAGGATTGAAAC	CCGCCCGGTCCCTGGAGCACCAGCCTGTCCCACGTTGCAC
CGGCCCGAAAGGGCCGGTGAGGATTGAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005838.1|WP_041444003.1|148385_149594_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_041443918.1|132414_134598_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	gnl|CDD|350688
NC_005838.1|WP_162467452.1|152874_153054_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174436.1|119269_124219_-|RecQ-family-ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	gnl|CDD|223588
NC_005838.1|WP_041443921.1|135280_137044_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	gnl|CDD|273839
NC_005838.1|WP_162467456.1|149726_152447_+|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|237512
NC_005838.1|WP_011174434.1|125671_131059_+|hypothetical-protein	unknown	unknown	gnl|CDD|226973
NC_005838.1|WP_011174427.1|139254_140007_-|LamB/YcsF-family-protein	unknown	unknown	gnl|CDD|377121
NC_005838.1|WP_148187591.1|143692_144850_+|ATP-binding-protein	unknown	unknown	gnl|CDD|224292
NC_005838.1|WP_041443928.1|145795_146056_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	unknown	unknown	gnl|CDD|376852
NC_005838.1|WP_011174437.1|118411_119251_-|hypothetical-protein	unknown	unknown	gnl|CDD|274008
NC_005838.1|WP_162467451.1|145010_145148_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_005838.1|WP_011174439.1|116352_117897_-|transcription-antiterminator-BglG	unknown	unknown	gnl|CDD|223153
NC_005838.1|WP_011174438.1|117872_118415_-|hypothetical-protein	unknown	unknown	gnl|CDD|130902
NC_005838.1|WP_041443916.1|131286_131565_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174415.1|154071_154275_+|AAA-associated-domain-containing-protein	unknown	unknown	gnl|CDD|370721
NC_005838.1|WP_011174431.1|134607_135297_+|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	gnl|CDD|187782
NC_005838.1|WP_011174422.1|145382_145799_-|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350313
NC_005838.1|WP_011174426.1|140034_143163_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl|CDD|239168

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	2.6e-98	323.5	0.0
NC_005838.1|WP_041443918.1|132414_134598_+|CRISPR-associated-helicase/endonuclease-Cas3	cas3	COG1203_cas3_CAS-I	9.8e-47	154.3	0.0
NC_005838.1|WP_011174431.1|134607_135297_+|type-I-C-CRISPR-associated-protein-Cas5	cas5	cd09651_cas5_CAS-I-C	3.4e-73	240.4	0.0
NC_005838.1|WP_011174436.1|119269_124219_-|RecQ-family-ATP-dependent-DNA-helicase	DinG	COG1199_DinG_CAS-IV-A	4.2e-78	257.9	5.6
NC_005838.1|WP_041443921.1|135280_137044_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	cas8c	cd09642_cas8c_CAS-I-C	1.4e-160	530.3	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005838.1|WP_041443918.1|132414_134598_+|CRISPR-associated-helicase/endonuclease-Cas3	gnl|CDD|350688	cd17930, DEXHc_cas3, DEXH/Q-box helicase domain of Cas3. CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.	8.23968e-53
NC_005838.1|WP_011174436.1|119269_124219_-|RecQ-family-ATP-dependent-DNA-helicase	gnl|CDD|223588	COG0514, RecQ, Superfamily II DNA helicase [DNA replication, recombination, and repair].	1.61084e-101
NC_005838.1|WP_041443921.1|135280_137044_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1	gnl|CDD|273839	TIGR01863, CRISPR-associated_protein_CT1133_family, CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG. CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein that tends to be found near CRISPR repeats of the DVULG subtype of CRISPR/Cas locus. We designate this family Csd1 (CRISPR/Cas Subtype DVULG protein 1). The species range for this subtype, so far, is exclusively bacterial and mesophilic, although CRISPR loci in general are particularly common among archaea and thermophilic bacteria. In a few species (Xanthomonas axonopodis pv. citri str. 306 and Streptococcus mutans UA159), homology to this protein family is split across two tandem genes; the trusted cutoff to this family is set low enough to capture at least the longer of the two.	0
NC_005838.1|WP_162467456.1|149726_152447_+|HEAT-repeat-domain-containing-protein	gnl|CDD|237512	PRK13800, PRK13800, fumarate reductase/succinate dehydrogenase flavoprotein subunit.	4.23096e-09
NC_005838.1|WP_011174434.1|125671_131059_+|hypothetical-protein	gnl|CDD|226973	COG4625, COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown].	5.29303e-07
NC_005838.1|WP_011174427.1|139254_140007_-|LamB/YcsF-family-protein	gnl|CDD|377121	pfam03746, LamB_YcsF, LamB/YcsF family. This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are subject to carbon and nitrogen metabolite repression. The exact molecular function of the proteins in this family is unknown.	6.89036e-140
NC_005838.1|WP_148187591.1|143692_144850_+|ATP-binding-protein	gnl|CDD|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	3.82929e-50
NC_005838.1|WP_041443928.1|145795_146056_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	gnl|CDD|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	1.14207e-11
NC_005838.1|WP_011174437.1|118411_119251_-|hypothetical-protein	gnl|CDD|274008	TIGR02168, Chromosome_partition_protein_Smc, chromosome segregation protein SMC, common bacterial type. SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins].	1.04221e-06
NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.7047e-87
NC_005838.1|WP_011174439.1|116352_117897_-|transcription-antiterminator-BglG	gnl|CDD|223153	COG0075, COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism].	0.00458444
NC_005838.1|WP_011174438.1|117872_118415_-|hypothetical-protein	gnl|CDD|130902	TIGR01843, Hemolysin_secretion_protein_D_plasmid, type I secretion membrane fusion protein, HlyD family. Type I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This model represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins. [Protein fate, Protein and peptide secretion and trafficking].	3.93849e-05
NC_005838.1|WP_011174415.1|154071_154275_+|AAA-associated-domain-containing-protein	gnl|CDD|370721	pfam09821, AAA_assoc_C, C-terminal AAA-associated domain. This had been thought to be an ATPase domain of ABC-transporter proteins. However, only one member has any trans-membrane regions. It is associated with an upstream ATP-binding cassette family, pfam00005.	4.76564e-10
NC_005838.1|WP_011174431.1|134607_135297_+|type-I-C-CRISPR-associated-protein-Cas5	gnl|CDD|187782	cd09651, Cas5_I-C, CRISPR/Cas system-associated RAMP superfamily protein Cas5. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas5 is a RAMP superfamily protein; Subunit of the Cascade complex; in subtype I-C this protein might be the endoribonuclease that generates crRNAs; also known as DevS family.	2.33328e-90
NC_005838.1|WP_011174422.1|145382_145799_-|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350313	cd18746, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	6.18974e-59
NC_005838.1|WP_011174426.1|140034_143163_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl|CDD|239168	cd02767, MopB_ydeP, The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins.	0

Protein sequences

>NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MMSARYLDPKKRHEFVFLFDVRDGNPNGDPDAGNLPRVDPETMHGLVTDVALKRKIRDYIALTREGKPRFAIFVQSRVALNRLILEGFQEAGIEPVSLQLAEEQMANESLLEHLDGLAEAGFSREGGTLYYSGQATTEKEIAKLLMGEEEAVAPFKKELEKLAKELAKAVKGRKITEEDRERAQAKLLERFFDIRMFGAVLSTGLNAGQVRGPVQLTFARSLDPIAPLEVSITRVAITREEDRARKETEMGRKPLVPYGLYRAHGFFNPFLAAKTGVQPEDLEALWDALQHLFELDRSAARGEMTVRGLAVFSHEDAKGNAPAHRLFGLIRVERREGVEAPRSFADYRVRAPKEGSLEAHGFPGVHLAWLVRPEGLEDLPPHVG
>NC_005838.1|WP_041443921.1|135280_137044_+|type-I-C-CRISPR-associated-protein-Cas8c/Csd1
MLRELKEAFHRFRKEGVLLPLAYKRKSVAWFIRLEGGKARLEGPYGKREGVEPIPAPDRQRSGKASEANLKPYLLVDDARYVLGLFEEGREDEAALLHKGFKELTEKAWRETQSPHVKVVLDLLSSPELGDLREEFRQKGGKPRDLLAFKVHGVLPTELEEVQAFWARHLAEEIQGGKGYCALCGTLGPVLRIFPREVVVLGQKCQLVSFNQKAFESFGKEQAANAPLCFTCASQVVDTLDYLIRSERHSRPLYREEEGGLRNQLAVFWLSEKVEVPLETPVDLETILGAVLSGALVHSPTPPADLTQLQELLATPWTGKAWPLNLDETRFHLAVLSANKGRLVVREWLAVSLSRLKETLGRFLEGTRLVRPWGEAPQPVPVGALVQALGDGNPGLVRGLLRTAYLGTPPPHALSLAIHLLRNPKTLTPEEREGWGRLHALVAALKLWLFYGKEEAKRMAELDKERKNPAYLSGRLLAVLEEAQKRASSYTLRRTLVDRFYGAASTTPAATFGVLLRLSTTAHLPKVGQELNQAVEEILSRLDEAGGFPRTLNLVGQAEFALGFYHQRAHFRANRAGKKGESAQGGS
>NC_005838.1|WP_011174431.1|134607_135297_+|type-I-C-CRISPR-associated-protein-Cas5
MARLKVKVWGEYACFSRPEFKVERVSYPVPTPSAARGLLEAIFWKPEFRYEVRRIGVLRLGTPFALLRNEVGNRMGAKPFFVEDARQQRTSLVLKDVAYLVEADMVLRPHATDPLPKYLEQFERRLKKGQYHHTPYLGTREFPAYFSPPDGEVPDGGLNLDLGPMLFDLAFVEDPGRPELTFKRPGRGEVQGYALPLFFHARIREGWLEVPAEKYQELYRLEEGHAKGA
>NC_005838.1|WP_041443918.1|132414_134598_+|CRISPR-associated-helicase/endonuclease-Cas3
MDPKAHTPNPQGAWHALKDHLEAVSRLAGGFAQHFGTPSLGQALALLHDLGKATRDFQAYLKVAAEGKRTNSVPHAVWGAALAYVALGSGQHEGWEAFGLPVMGHHAGLPKRGEAASKLAQALKEEPFKEVAAFLRSSELRTRLEGLLNEALKEVRSKTAGDPLRLDFLVRMAFSALVDADYLDTEAHFDPSVARLRQEGYSLEKLWARFHRDQEALLQRVRPSLVNSVRREVYEACLQAAELSPGLFRLTVPTGGGKTRSGLAFALRHALKHGLRRVVVAIPYTSIIDQTAQVYREILGEEAVLEHHSAYEPPLGEEQEENVLRQRLATENWDAPLVVTTTVQLFESLFSNRPSKMRKVHRLARSVILLDEVQTLPPELLKPTLEALRLLATPVEEGGYGATVVLSTATQPTFEVVPTFQGLPVREIVPDYPRHFARLQRVVYERRPKPLSWEELARELQARPQVMVVLNTRKDALALLEALGEDPHAYHLSTLLCPAHRREVLEEVRRRLREGAPVRLISTQVVEAGVDLDFPEVWRAIGPLDRVVQAAGRCNREGRLDKGKVVLFWPEEGTTPRGPYRVGVEKARLLLEEHPPERLHDPGLYQAYFKELFTTVKTDKGIQEHRKDLDYPEVARRYRLIQEDTVSVVVPYGEGLARLEAFQKAPSLQNWRRLQAYVVGLFRNQVRERRGFLEAVPGFQDLYVWRGSYDPRRGLVEEYADPSDLIV
>NC_005838.1|WP_041443916.1|131286_131565_+|hypothetical-protein
MLEYCVAYRNLGTAPVSQFVLTDPVPFFTDPLPSVPDYGGKAIRWSHGSATLYLTASQGDDAGEVSGGVVRVEVGNVGPGEAGEVCYRVQIR
>NC_005838.1|WP_011174434.1|125671_131059_+|hypothetical-protein
MKRVFALVLLLLPALAQPVARELKATVVGDGVGWETHALRIWLVIPEKGRVRLDLFSPGFDPTDYRSALLGKPELGDERYDGGKGELKATFRLYRDGKPLREMAFGVEPHRWVPFFEGEMEAGVYLFESELLGNGKNTFVLRVEAPSFKLSLDPKPQLILDVFTQTTTLRLLPDERGRVWVEPLGVYSEGPLEVAFYDEDGPEELRARVRYEDGSVEERPVSGDREWTTYTKRPGLALFGFTQPPTARQHSNTVAFRVGACTSLENGVLKAIPPGEARARVVDEEGKPLPVPVEEKDRVFRPLLPEGASLLRVEARGAVFVQEGWAEVGCPGGEVTFVVRLPKPPAPERPPQGEVRFRVAVALPGGDLPAKATLRLGDLEAPVDGERTLALPRGRYPLAVLAEGARVEAPQEVEVLPGKRQEVLVRLLPEVALSLAPKEVYLRVGEEGEVVLTATTPYPGLLPAELSLELPEGLTPLGASRAQGPLTKDRPFQLRVRFLAEKEGTYALSGLLAPWGLKAEGRAVVVRPATFRLVKEALTPEVEAGGVARFRVTVVNEGDEEGRALLVDRFLGTEERREVFLKAKEGRSYEFAFPVPLEAQGTLVNRAELSTGEKAEAGVRVLRPKAHLERSLPHRVYLPGEEVVLSFLVENRGEAPMRYVLEDACPDWLSPLEPARFEGYLKPGEEALHAYRARVLLGPEAEGACAATLRTPTETLRAEVALKRRPLLLEKEADPPRLLEGGQGVFRLRVRNPADHRVEVELRDIPGKGLGMDPWSERVALEAGEERVFTLPFRAEAVGELENGLSAFLGETPAAFPVKAKVAVLPVLVPERTSVVRLPFRVEGEGDALLLGFKPPEGAEYSPGSARLDGRPVEEPRVLPDGTLVWRLPFAREGLLTLTLLHTRALPPLPEPALTLLRLDRELPLKGGLRLRDYEGAKPLSAKRKGPIREPMDGAIVQQEAVALRIEAPLGPIAVRVNGLEVEGRLLGEAQYDEERKVQRLAYYGVPLRPGRNVIEVEGPGFYDKVEVFRPGPPKDLVLEPVRLRADGRTPLEFRLKAVDGMGLPTGFGLATLEADPEPIAPDASLLEPGYQVLLRDGVGTVMLKPLLTPKEVRLRARFNDLEKTFRLFAGGSQEPLWLAQGSVGVAYDPEEGRPRLFGLARGYVEAPLEGGFLQGALDTTGGLSQTPEAGFFPITGSGEEARRPLASDDPVALRYTTPEYTLAYERGPLAPGLGEATALRLATRGDARVEAFLALLPKGSVREEIVPDGTAFYRLSGSPAPGSLRLFLVEGGRTRALEAGVDYTYDFLSGEIVLARPLAPFTPEFAPVRLVAEYAPLSAPREELALGARAAYEAGPWRFGLGGYLRLDLQGFASQGYALGASLAYGEGGSEVGLEAAFAGKWRFGLSAALSEGPLEARGNLAYEEGGEVQGAFRAAYDLGPGAVALEHTTPGRTGLVYEAKLARGFRFGLGAGYAWREGGLYLLGRAAYQEGRARFGLSHAYLLSGGQETRLDLLWPLGEALEAEGSLAYLWGEGLQGAFGLRQRLGSANLALSYQLPTASGEGNRARFGLEAPLPLTENLSANLGLYALYAFSGGQGELGGSLGLRYAREGLVATFGVEGALGPKLTLRGGAAGSLDPENTLGLDFALSLLPEAKGRFSLAYALRASDLSLLTYHRYATETGLLEGQLAAAYAPFPAFSVRPAFGYRYPFPDPEGATYALGLYATLFPTELLGLGGGASYTFQPATGASDLSFSVEGTLRLSPLWLSLGYQFGPSLFAPEGVYLRLDVFGGSR
>NC_005838.1|WP_011174436.1|119269_124219_-|RecQ-family-ATP-dependent-DNA-helicase
MAFGVSHPVALDLEATSTDPSEAEVLEVAAVDGEGRVFHRYLATQRPLPPDHEVFQLTGIPYEEYEAKKVAPKEALEELLAFLGGRPLLGHNLLRYDLPLLQRHLEEAGLPRWQGEALDTLRLAHLLFPTPPGGLEGYRLGDLYAFLLGRPLEGAHRALNDAQATLAVFHRLLDRGRRALAQHPGLVRAWRELGLPEGHLFPEDEGLIKDLLAREADVEAFFVEKEGRPFPAPTDLGPDLLPKPRPAQRRMFQLVEEALSREEILLLEAPTGTGKTKGYLYPVLHQRKPTWVATHTKVLQAQAMEELRAVAQKGYQVRAALVKSPQDTLCPDRLLEAFLREARSGKPGEDVGAAIAVLLHYAAQRGHDLEALPAYWHFLEGFREVRGRVGTNPDRCRRECPFASACAYQAILRRREEAQILVTNQAYLLHSLLGEKALPEARPALVLDEAHHLEDVATEALTLKVDGEGLRHLLEALANPSKRSGLLQERDYLKSLEDDLRASAETLAEEAVPKALEALKAYSERMERFLKRRGVGSPEHGLTLPLEPSWTRDEEYPLLDREERHLIQSLEALAKGLEGLLDAHPPPWPLLLREIRPLLQELRQAIRLFLRRKRVLKGEADEALHLTRLDPVTGTWSHLAEPIEVAAELEEKLWPAFRGVVLTSATLAVPTETDPEGFAFLQRALGLPPQARAERLPPSLPYHRAHLLVPRHLPEARESTLPRFQRLLHRELRLVLGQVPRTLTLFTSLSRLEAAKKALEDLPHLRAPLTRREREDTVRFARSNPTEPLAALGSRSFMEGVDLPHLRVVNLERLPFPYPSPLLKRRMALAYERGLDPWEDYYLPKAVLSFVQAFGRLIRDDRQVAGDGAFILWDKKLLHADYQELFYRALPDGVAHHFPGDRQAFYRKLEEILGLAFPGAEEELSEEAWAKVKAILAEAGLGPLERARRLAEEVHGVLVDEARWAKQREAVRAALEGRHLLALLPTGFGKSLAFQIPAWMSPGLTLVISPLVALMKDQVDRLQELGLPALALHGLMSWGEQASVLDEVRAGQVRLLYLAPERINRSEAVRKALRELREAGKLVRVVFDEAHCLLEWGYDFRPDYLKVLEWLRELGLPMSFFTATLTPEERARLKEVAGIPEAVEVLPETFHRPNLRFVVRQAPGEVGKFDRLAQALLWVEKTGGSAIVYATSRAETERLAWALDRLFPSLGVEAYHAGLGPVLRKEVQERFMRGESRVVVATTAFGMGVDKPDVRLVVHWRPPLSLEEYAQQAGRAGRDGKEAYALLLYTHGDWGFLRWMVGLGQRGTERLEALAERLLARLPFRGYRKELLELLMTEGAEEAAEEEASDLEAGPALSGEDLERLLLGMEQAGLIRYEYLPGKASLYLSPEQWEAFARTPGLAERLVRAGYRPGSRQNVLDLSKLPREEAEDLDRYLYQAYRKGEAILYRYREPLLLVERMDPGKIVRWRASLEASRARALERLGRVQAYATQGRCRALVLLSHLNGERRRCGTCDVCAQDGGPWEAMENFHEEELLRAYKPLDTLLAFFRWAEDHYPQKPLLGRKATLMALRGKAWTGNGPLHRRYLENRFFGHLSFLKPKELEQAFREALERGYLEQKGSWQGHPLFGLTDHGRQRLRKGARGKEAR
>NC_005838.1|WP_011174437.1|118411_119251_-|hypothetical-protein
MDPSKAFRIPSLEELPPRETPLRPTTPPLPEFTPTGEGALPALDPKAKATPAPPPERGPLSLQGELKRTRDQLERLKVKLAQAEKARAEAVKERDKARQEAAVLRKQVEALTASHAAMRQALEKAQEDLKILQEELETLKKEKGELETLRKERDELFARAARWEKAETLRERLQEPFPIEAFFRMLFVPYSELGPGPEVRLLALIEGYRALLQGKEHPMLSRTNRELLSGEPEGIVLLGVERLLLDLAESPLPRWLKTHAWLAEAFLTREKLSSPREEA
>NC_005838.1|WP_011174438.1|117872_118415_-|hypothetical-protein
MTWEEEKKALEARFREDLAWYEREWEACRRKLEEERQEWNATRKRLLNELSQSSRKVWELKKRLEALQGLEERYSALEREVRGLRRKLAALDRPAIGRRYLEALREDLALWDELLLAEAERLQTRGLEGFLQELWAKREAAFRHWQAGEDVDFATVRTALVLEWAIWTWLEAGWNPGRTP
>NC_005838.1|WP_011174439.1|116352_117897_-|transcription-antiterminator-BglG
MEPWAHAVNLHRAVEAALEAQNLAHLQVRREDVEGAKPLVRALWRGEWRADPLAKSREGVVPGYLLLGFLGGHFFDRDLPENDLAFWPEFHRALGLNQGQPTPKQRDKLWKVLEGLPGTKAFLRFHADGKRDFVGTLKALFGARTLRLKEILDHLRLYRDEAKLQEEALGPYASLVRGLKEALDLLAEEALDAAEQEDVEALVARLEALGFYAEEPHPLRFLFHRSPKAFAELYAEWRGEKKATPLRHPQVRVEVLQGKEVLERVLPQIRREVLVEGALVYGQVRLKSGLFRGFCWRPRLDTEGNPIPEEVAVPLGEGQVVLRLHHRAWGVRFLDERGQVCPEWRPPEPLEVRPLVDEGTPVRFLLEGGGDPVERLEDLPLELGLPEDALVVEALVFGSREHGEWRPLGRLPVRLEARLEERLSETALELEVFPRGPLETVWLAPAGPKQTFPEGRACIPRGLWPVKILVKAWGRAWEILVPPKGWPEKAWRRGLGLPAVGANKLGNNPSRFHL
>NC_005838.1|WP_011174427.1|139254_140007_-|LamB/YcsF-family-protein
MKVDLNADAGESYGAFAYGHDREIFPLVTSANLACGFHGGSPGRILEAVRLAKAHGVAVGAHPGFPDLVGFGRREMALSPEEVYADVLYQIGALSAFLKAEGLPLHHVKPHGALYLKACRDRETARAIALAVKAFDPGLPLVVLPGTVYEEEARKAGLRVVLEAFPERAYLRNGQLAPRSMPGSWITDPEEAARRALRMVLEGKVEALDGGEVAVRAETLCIHGDNPNAPEVARAVREALEQAGVEVRAF
>NC_005838.1|WP_011174426.1|140034_143163_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MAWLNPFWSSPKAYVRPPKRGLAPELWASRIPFTHLENFYEVFRALWENRDNLPYAWRILKDGVCDGCALGTSGLEDWTLHGVHLCNVRLRLLRLNTLPPLDPKVLEDVEALKGRKSRELRRLGRLPYPMLRRKGERGFRRVSWDEALGLAAEYLRRHLPEGAFFYLTSRGVPNETYYVVQKAVRALGCNHVDNAARICHSPSTVVLKEALGVAATTCSYTDLIGTDLVVFLGSNVANNQPVMMKYLYHAKKAGTKVAVVNPYREPGMERYFVPSDLESALFGTRIADRFFQILPGGDIAFLHGAAKWMLEEGWVDPGFIRAHTAGFEAYKALLEAIPFAELEKAAGVSREEMRAFAEMVGRAERAVFVWGMGITQHTHGEDNVRAIVNLALLKGFVGREGCGLMPIRGHSGVQGGAEMGAYATAFPGGLPVNPENARRLAELWGFPVPDRPGLTTPEALDRALEGRLGVLWAIGGDFREVMPDPEAVEEALRRVPLRVHQDIVLSSQMLLEPGECVLLLPATTRYEVPGGVTETSTERRVIFSPEIPGPRPPEARPEWEVFQELVHRLRPELKDRFRFASTAEVREEIARVIPLYEGIQRLKAKGDQFQYGGRHLCEGWRFPTPDGKAHFRPVPPAPKGGPRGGLPRGHPPGEAVQLHRPRGPGPPHRGLPGRGLHEPQGRRPPGPEAWGSGGAGKRLRPLRRPGLPGGGQRGHPGGPLARGERPGRPQGPLPPGPHPGLQGGPRPPAAGGGGGPFPAPAMRGKARVRVARLEGGRWREVRDEVAAEAPLEIRLRYRDEVASLGVVLRTPGQDAELAAGLLYTEGLLQDPKEVLAIAPCADGSLPPEAREGVIQVFLRHPLPPPPKRHLALTAACGACGREALPDLGKLGLSPPPPLAVDPDLLLALPERLGEAQRLFRATGGLHAAALFDREGRLVALREDVGRHNALDKLIGWAFLQGKLPLHDHILLVSGRAGYELLVKAVAAGIPVFCAVSAPTSLAVALAQAYGLTLVGFLRPGRMNVYAGRERVGPPRGLPNPCG
>NC_005838.1|WP_148187591.1|143692_144850_+|ATP-binding-protein
MAQEVAPPTPKGKRGRRAWKRCSSRSSPVFTSTTAAQLDPQGFLSGLQGRVVLDEVQRAPGLFLPLKALVDRDRRPGRFLLTGSANVLALPRAAEHLVGRMALFTLWPLSQGELEGRKEGFLSALFAEEVPPVQGEGRWPLERLLRGGYPEAVRLPPERRGAWFRDYLATVLAREVRELSQVERLGELPRLYALLATRPAQLLNWAELSRASSLPATTLKRYFALLEALYLVRTLPPWQANLGKRLTKSPKVLPTDPGLALHAAGLDGARLEGDPILLGKYLEAFVAMEVVKQAGYAGVAVEVFHYRSHSGEEVDLVLEGPGGKVVGVEVKARGSLRPEDLRGLKSLAQALGPRFHRGVVLYLGRETVPFAKDLYALPLEALWRL
>NC_005838.1|WP_162467451.1|145010_145148_+|hypothetical-protein
MEEALRLVQGEPAAEKALESLLCGVEVPLVAALLLGKLAGPGSGA
>NC_005838.1|WP_011174422.1|145382_145799_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MSYLLDTNVVSEAAKQRPHPKVLAWLSETPLGQAYLSALTLGELVQGVVRAPEARKPGLERWLEGLKQRFAGRILPLDAEVMETWGLLTGEALREGRPLSPLDALLAATALRHGLVLVTRNVAHFRGLPLRLLNPWEE
>NC_005838.1|WP_041443928.1|145795_146056_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin
MGRVWQLQEAKARFSEVVERALKGEPQTVTRRGRPVVVVVDWATYTRLRGEEASLWEALRAPEPLSEEEAETLFTREAAGYREVGF
>NC_005838.1|WP_041444003.1|148385_149594_+|hypothetical-protein
MLLGWFVAGYGYAQIRGGAETARFEPGDRILYQEDLSGTPIGEQVEGWEILQGSYEVAEFQDRRWFRPLAYNTHILRRVDFPQDFSVEFTVYLFEPGNAELRVFLHTEEEVRRGPGPDGPAQIYLTVARYGNRDGFWLRAWNPDNRRLQDVARDERRLQPDTVHHVSLQVRGGRLNLFIDGERVATTPFRPDAPLRAISFRFLSRGGHELPYKDRPALLDALRIAGYSRPVGRATGGVFLYWMFPGGQENLPQLQAAQNQTISSSAALDALGGEPRTVEGTLVPIDLPANPFAPGEVQVRADGQAWQAFVRRLQANLEAVRQAGGGLVIVGDGGDGRTERERRLLANQRALAFAAWLAQQGIGNPQNLLSIVAENGGYESILFVVDNGGYRGIMSLRMEPRR
>NC_005838.1|WP_162467456.1|149726_152447_+|HEAT-repeat-domain-containing-protein
MEAARTPAEALPLLERLGRALSEGELFGEEARIARLTARFWQDPAAPPEVVERLQHIYGMIAPALAVMDPPLAETLLVRVPLTWATSDDAIRRKQGLAVLIQSWELFFGYEQQEILLQALPSVLAQAATWPEEAFEAILSFLANRVTFSSEAHLPDSLPEVFVERLRRHQGNYAWRLPDILALDTTETGTDRLIAWAQSPPPLPPSLAAYRQRWREAFLAKLDGRQLTLEQKRRVVALLSDPGLRDAVFRLVRTWRYRGEPLPPPPPESLPLLEEWAVREYCEEAVRLLAAAGPEGLTRLFRVAMEDLRDRDAPIREPRPCEWDRWSALFAHAEAIADRIGAAYREGPTPRLLRLLARAGRWEVVLEALSSPEAALRREAAFLLALAVAPEEDALARTGDAGQGQALVASWQKRPELHPRPREALRQALRDEDPNVQREALRALLSLGDETAWPVLLAALRVENEDRFQTFLSGSGFRPALTDSLAGALAEVAGGDPSEAVRRRAVVLLGRAEPGPWQAAVEPVLRGLLRDPDQEVRRATAEYFAAVPAREVATTAALLEATRDASMYVRHAAAMALGLARGWTPELVDRLEVRLREGDPDANVVRALEDAYPHALRRAPGAVDRLLAIVLERKGPARWRKALAEGPQADAAVAWELLERLEARPLKDWAPVPPGSGPGLLQRMVEFFVRAEEDPPPLGIIGRLVPREMLDPFLVRRALEDPEASLGHRLWLIQQALEIPEDLQEDVWRLLMRALRAGEGGPMTLALLGRWGFDGVRRLVEELWGEPETLRHVARHLRQQEGLGKLQMATGNVGGLRLPKPAAEDLPWVEATLARLAPGARDPRLEPLVDLLGLWDLGNDSALRKAAFRYRIPQLLLRHLADPLECRAVAEAVGSLFGRGVTPRCR
>NC_005838.1|WP_162467452.1|152874_153054_-|hypothetical-protein
MRKMKLGICTRRIMGVFEGLHRWKATGERGDEKKKRIFAFRKGKTGFQDPRPEVRTRAL
>NC_005838.1|WP_011174415.1|154071_154275_+|AAA-associated-domain-containing-protein
MPLVKEIHRRVLAQGRLREEEALEALQARFPQAEARRVWRRLLEWSRFAGLFAYDESSRTLYPPGAA

Crispr_ID: NC_005838_6

• CRISPR_ID: NC_005838_6
• CRISPR_location: 153106-153599
• CRISPR_type: TypeI
• Repeat_type: III-A
• Spacer_info: 6 spacers
• Cas_protein_info: cas7b

Consensus repeat of NC_005838_6

Consensus_repeat	Method
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	PILER-CR
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	CRISPRCasFinder
GTTGCAAGGGATTGANCCCCGTAAGGGGATTGCGAC	CRT

spacers of NC_005838_6

>6.1|153142|42|NC_005838|PILER-CR,CRISPRCasFinder,CRT
GGCCCCTGACGAGGTTCCTAGGTGAGGTCGGTCTCCTTCTGG
>6.2|153220|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT
CCCCCGTGTGGGAGGTGGACCTGGGGGGCCTCGAGAT
>6.3|153293|40|NC_005838|PILER-CR,CRISPRCasFinder,CRT
GCTCCGGGTGGGCCCCGTCCTCCTCGGGCCCGAGAGGAGA
>6.4|153369|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT
TGATGCTGATCATTGCTCACCTCCTGCCCGGAGGTGG
>6.5|153442|42|NC_005838|PILER-CR,CRISPRCasFinder,CRT
AAATGCGGTCCTGGAGTGGGAATACAACGAAGTTTCCGTTCA
>6.6|153520|44|NC_005838|CRISPRCasFinder,CRT
ACGGTACCGGCGAAGGACTTGGCCACACCTTGAATGACCGTCAT

CRISPR arrays and Neighbor proteins around NC_005838_6

CRISPR arrays

The CRISPR arrays of NC_005838_6

>merge|NC_005838|6|153106-153599|PILER-CR,CRISPRCasFinder,CRT
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGACGGCCCCTGACGAGGTTCCTAGGTGAGGTCGGTCTCCTTCTGGGTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGACCCCCCGTGTGGGAGGTGGACCTGGGGGGCCTCGAGATGTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGACGCTCCGGGTGGGCCCCGTCCTCCTCGGGCCCGAGAGGAGAGTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGACTGATGCTGATCATTGCTCACCTCCTGCCCGGAGGTGGGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACAAATGCGGTCCTGGAGTGGGAATACAACGAAGTTTCCGTTCAGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGACACGGTACCGGCGAAGGACTTGGCCACACCTTGAATGACCGTCATGTTGCAAGGGATTGAGCCCCGTAAGGGGATTGATAC

>NC_005838|6|6|153106-153519|PILER-CR
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	GGCCCCTGACGAGGTTCCTAGGTGAGGTCGGTCTCCTTCTGG
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	CCCCCGTGTGGGAGGTGGACCTGGGGGGCCTCGAGAT
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	GCTCCGGGTGGGCCCCGTCCTCCTCGGGCCCGAGAGGAGA
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	TGATGCTGATCATTGCTCACCTCCTGCCCGGAGGTGG
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	AAATGCGGTCCTGGAGTGGGAATACAACGAAGTTTCCGTTCA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC

>NC_005838|6|5|153106-153599|CRISPRCasFinder
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	GGCCCCTGACGAGGTTCCTAGGTGAGGTCGGTCTCCTTCTGG
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	CCCCCGTGTGGGAGGTGGACCTGGGGGGCCTCGAGAT
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	GCTCCGGGTGGGCCCCGTCCTCCTCGGGCCCGAGAGGAGA
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	TGATGCTGATCATTGCTCACCTCCTGCCCGGAGGTGG
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	AAATGCGGTCCTGGAGTGGGAATACAACGAAGTTTCCGTTCA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	ACGGTACCGGCGAAGGACTTGGCCACACCTTGAATGACCGTCAT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGATAC

>NC_005838|6|5|153106-153599|CRT
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	GGCCCCTGACGAGGTTCCTAGGTGAGGTCGGTCTCCTTCTGG
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	CCCCCGTGTGGGAGGTGGACCTGGGGGGCCTCGAGAT
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	GCTCCGGGTGGGCCCCGTCCTCCTCGGGCCCGAGAGGAGA
GTTGCAAGGGATTGAACCCCGTAAGGGGATTGCGAC	TGATGCTGATCATTGCTCACCTCCTGCCCGGAGGTGG
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	AAATGCGGTCCTGGAGTGGGAATACAACGAAGTTTCCGTTCA
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	ACGGTACCGGCGAAGGACTTGGCCACACCTTGAATGACCGTCAT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGATAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005838.1|WP_162467451.1|145010_145148_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174411.1|156489_158076_-|IS200/IS605-family-accessory-protein-TnpB-related-protein	unknown	unknown	gnl|CDD|273793
NC_005838.1|WP_162467452.1|152874_153054_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_008633605.1|156057_156234_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174410.1|158235_158691_-|PIN-domain-containing-protein	unknown	unknown	gnl|CDD|379205
NC_005838.1|WP_162467456.1|149726_152447_+|HEAT-repeat-domain-containing-protein	unknown	unknown	gnl|CDD|237512
NC_005838.1|WP_011174427.1|139254_140007_-|LamB/YcsF-family-protein	unknown	unknown	gnl|CDD|377121
NC_005838.1|WP_008630619.1|160288_160978_+|IS5-like-element-ISTth7-family-transposase	unknown	unknown	gnl|CDD|376573
NC_005838.1|WP_148187591.1|143692_144850_+|ATP-binding-protein	unknown	unknown	gnl|CDD|224292
NC_005838.1|WP_011174406.1|161358_161760_+|acyl-CoA-thioesterase	unknown	unknown	gnl|CDD|224523
NC_005838.1|WP_041443928.1|145795_146056_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	unknown	unknown	gnl|CDD|376852
NC_005838.1|WP_041444003.1|148385_149594_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	gnl|CDD|377458
NC_005838.1|WP_158300316.1|155019_155325_+|hypothetical-protein	unknown	unknown	gnl|CDD|271141
NC_005838.1|WP_011174405.1|161740_162715_+|ribonucleotide-diphosphate-reductase-subunit-beta	unknown	unknown	gnl|CDD|153108
NC_005838.1|WP_011174409.1|158671_158914_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|273625
NC_005838.1|WP_011174414.1|154398_154719_+|antibiotic-biosynthesis-monooxygenase	unknown	unknown	gnl|CDD|225209
NC_005838.1|WP_011174415.1|154071_154275_+|AAA-associated-domain-containing-protein	unknown	unknown	gnl|CDD|370721
NC_005838.1|WP_011174422.1|145382_145799_-|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350313
NC_005838.1|WP_011174426.1|140034_143163_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	unknown	unknown	gnl|CDD|239168

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	cas7b	pfam05107_cas7b_CAS-I-B:CAS-I-C	2.6e-98	323.5	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005838.1|WP_011174411.1|156489_158076_-|IS200/IS605-family-accessory-protein-TnpB-related-protein	gnl|CDD|273793	TIGR01766, Putative_transposase_MJ0751, transposase, IS605 OrfB family, central region. This model represents a region of a sequence similarity between a family of putative transposases of Thermoanaerobacter tengcongensis, smaller related proteins from Bacillus anthracis, putative transposes described by pfam01385, and other proteins. [Mobile and extrachromosomal element functions, Transposon functions].	6.455e-12
NC_005838.1|WP_011174410.1|158235_158691_-|PIN-domain-containing-protein	gnl|CDD|379205	pfam13470, PIN_3, PIN domain. Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).	3.7123e-08
NC_005838.1|WP_162467456.1|149726_152447_+|HEAT-repeat-domain-containing-protein	gnl|CDD|237512	PRK13800, PRK13800, fumarate reductase/succinate dehydrogenase flavoprotein subunit.	4.23096e-09
NC_005838.1|WP_011174427.1|139254_140007_-|LamB/YcsF-family-protein	gnl|CDD|377121	pfam03746, LamB_YcsF, LamB/YcsF family. This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are subject to carbon and nitrogen metabolite repression. The exact molecular function of the proteins in this family is unknown.	6.89036e-140
NC_005838.1|WP_008630619.1|160288_160978_+|IS5-like-element-ISTth7-family-transposase	gnl|CDD|376573	pfam01609, DDE_Tnp_1, Transposase DDE domain. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. This family contains transposases for IS4, IS421, IS5377, IS427, IS402, IS1355, IS5, which was original isolated in bacteriophage lambda.	0.00046212
NC_005838.1|WP_148187591.1|143692_144850_+|ATP-binding-protein	gnl|CDD|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	3.82929e-50
NC_005838.1|WP_011174406.1|161358_161760_+|acyl-CoA-thioesterase	gnl|CDD|224523	COG1607, COG1607, Acyl-CoA hydrolase [Lipid metabolism].	2.65943e-46
NC_005838.1|WP_041443928.1|145795_146056_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin	gnl|CDD|376852	pfam02604, PhdYeFM_antitox, Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems. When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin. This domain complexes with Txe toxins containing pfam06769, Fic/DOC toxins containing pfam02661 and YafO toxins containing pfam13957.	1.14207e-11
NC_005838.1|WP_011174422.1|145382_145799_-|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350313	cd18746, PIN_VapC4-5_FitB-like, uncharacterized subgroup of the PIN_VapC4-5_FitB-like subfamily of the PIN domain superfamily. The PIN_VapC4-5_FitB-like subfamily includes the Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis VapC4 and VapC5 ribonuclease toxins of the VapBC toxin/antitoxin (TA) system, and Neisseria gonorrhoeae FitB toxin of the FitAB TA system. This subfamily belongs to the VapC-like family of the PIN domain nuclease superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	6.18974e-59
NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2	gnl|CDD|377458	pfam05107, Cas_Cas7, CRISPR-associated protein Cas7. CRISPR-associated protein Cas7 is one of the components of the type I-B cascade-like antiviral defense complex. In Haloferax volcanii, Cas5, Cas6 and Cas7 form a small complex that aids the stability of CRISPR-derived RNA.	4.7047e-87
NC_005838.1|WP_158300316.1|155019_155325_+|hypothetical-protein	gnl|CDD|271141	cd14658, Imelysin-like_IrpA, Imelysin-like domain in iron-regulated protein A. This family includes putative iron-regulated protein A (IrpA) mainly from Bacteriodes, proteobacteria and cyanobacteria, with domain similar to insulin-cleaving membrane protease (imelysin, ICMP) protein. It has been shown to be essential for growth under iron-deficient conditions in the cyanobacteria Synechococcus sp. The conserved GxHxxE motif is similar to other known imelysin-like proteins that are regulated by iron, such as ICMP, IrpA and EfeO. Imelysin is a membrane protein with the active site outside the cell envelope. The tertiary structure shows a fold consisting of two domains, each of which consists of a bundle of four helices that are similar to each other, implying an ancient gene duplication and fusion event.	1.74696e-17
NC_005838.1|WP_011174405.1|161740_162715_+|ribonucleotide-diphosphate-reductase-subunit-beta	gnl|CDD|153108	cd01049, RNRR2, Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain. Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.	2.87151e-57
NC_005838.1|WP_011174409.1|158671_158914_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	gnl|CDD|273625	TIGR01439, Uncharacterized_protein_Mb2626, looped-hinge helix DNA binding domain, AbrB family. This DNA-binding domain family includes AbrB, a transition state regulator in Bacillus subtilis, whose DNA-binding domain structure in solution was determined by NMR. The domain binds DNA as a dimer in what is termed a looped-hinge helix fold. Some members of the family have two copies of the domain in tandem. The domain is found usually at the N-terminus of a small protein. This model excludes members of family TIGR02609. [Regulatory functions, DNA interactions].	0.000304509
NC_005838.1|WP_011174415.1|154071_154275_+|AAA-associated-domain-containing-protein	gnl|CDD|370721	pfam09821, AAA_assoc_C, C-terminal AAA-associated domain. This had been thought to be an ATPase domain of ABC-transporter proteins. However, only one member has any trans-membrane regions. It is associated with an upstream ATP-binding cassette family, pfam00005.	4.76564e-10
NC_005838.1|WP_011174414.1|154398_154719_+|antibiotic-biosynthesis-monooxygenase	gnl|CDD|225209	COG2329, COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only].	2.73542e-31
NC_005838.1|WP_011174426.1|140034_143163_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD	gnl|CDD|239168	cd02767, MopB_ydeP, The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins.	0

Protein sequences

>NC_005838.1|WP_162467452.1|152874_153054_-|hypothetical-protein
MRKMKLGICTRRIMGVFEGLHRWKATGERGDEKKKRIFAFRKGKTGFQDPRPEVRTRAL
>NC_005838.1|WP_162467456.1|149726_152447_+|HEAT-repeat-domain-containing-protein
MEAARTPAEALPLLERLGRALSEGELFGEEARIARLTARFWQDPAAPPEVVERLQHIYGMIAPALAVMDPPLAETLLVRVPLTWATSDDAIRRKQGLAVLIQSWELFFGYEQQEILLQALPSVLAQAATWPEEAFEAILSFLANRVTFSSEAHLPDSLPEVFVERLRRHQGNYAWRLPDILALDTTETGTDRLIAWAQSPPPLPPSLAAYRQRWREAFLAKLDGRQLTLEQKRRVVALLSDPGLRDAVFRLVRTWRYRGEPLPPPPPESLPLLEEWAVREYCEEAVRLLAAAGPEGLTRLFRVAMEDLRDRDAPIREPRPCEWDRWSALFAHAEAIADRIGAAYREGPTPRLLRLLARAGRWEVVLEALSSPEAALRREAAFLLALAVAPEEDALARTGDAGQGQALVASWQKRPELHPRPREALRQALRDEDPNVQREALRALLSLGDETAWPVLLAALRVENEDRFQTFLSGSGFRPALTDSLAGALAEVAGGDPSEAVRRRAVVLLGRAEPGPWQAAVEPVLRGLLRDPDQEVRRATAEYFAAVPAREVATTAALLEATRDASMYVRHAAAMALGLARGWTPELVDRLEVRLREGDPDANVVRALEDAYPHALRRAPGAVDRLLAIVLERKGPARWRKALAEGPQADAAVAWELLERLEARPLKDWAPVPPGSGPGLLQRMVEFFVRAEEDPPPLGIIGRLVPREMLDPFLVRRALEDPEASLGHRLWLIQQALEIPEDLQEDVWRLLMRALRAGEGGPMTLALLGRWGFDGVRRLVEELWGEPETLRHVARHLRQQEGLGKLQMATGNVGGLRLPKPAAEDLPWVEATLARLAPGARDPRLEPLVDLLGLWDLGNDSALRKAAFRYRIPQLLLRHLADPLECRAVAEAVGSLFGRGVTPRCR
>NC_005838.1|WP_041444003.1|148385_149594_+|hypothetical-protein
MLLGWFVAGYGYAQIRGGAETARFEPGDRILYQEDLSGTPIGEQVEGWEILQGSYEVAEFQDRRWFRPLAYNTHILRRVDFPQDFSVEFTVYLFEPGNAELRVFLHTEEEVRRGPGPDGPAQIYLTVARYGNRDGFWLRAWNPDNRRLQDVARDERRLQPDTVHHVSLQVRGGRLNLFIDGERVATTPFRPDAPLRAISFRFLSRGGHELPYKDRPALLDALRIAGYSRPVGRATGGVFLYWMFPGGQENLPQLQAAQNQTISSSAALDALGGEPRTVEGTLVPIDLPANPFAPGEVQVRADGQAWQAFVRRLQANLEAVRQAGGGLVIVGDGGDGRTERERRLLANQRALAFAAWLAQQGIGNPQNLLSIVAENGGYESILFVVDNGGYRGIMSLRMEPRR
>NC_005838.1|WP_041443928.1|145795_146056_-|type-II-toxin-antitoxin-system-prevent-host-death-family-antitoxin
MGRVWQLQEAKARFSEVVERALKGEPQTVTRRGRPVVVVVDWATYTRLRGEEASLWEALRAPEPLSEEEAETLFTREAAGYREVGF
>NC_005838.1|WP_011174422.1|145382_145799_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MSYLLDTNVVSEAAKQRPHPKVLAWLSETPLGQAYLSALTLGELVQGVVRAPEARKPGLERWLEGLKQRFAGRILPLDAEVMETWGLLTGEALREGRPLSPLDALLAATALRHGLVLVTRNVAHFRGLPLRLLNPWEE
>NC_005838.1|WP_162467451.1|145010_145148_+|hypothetical-protein
MEEALRLVQGEPAAEKALESLLCGVEVPLVAALLLGKLAGPGSGA
>NC_005838.1|WP_148187591.1|143692_144850_+|ATP-binding-protein
MAQEVAPPTPKGKRGRRAWKRCSSRSSPVFTSTTAAQLDPQGFLSGLQGRVVLDEVQRAPGLFLPLKALVDRDRRPGRFLLTGSANVLALPRAAEHLVGRMALFTLWPLSQGELEGRKEGFLSALFAEEVPPVQGEGRWPLERLLRGGYPEAVRLPPERRGAWFRDYLATVLAREVRELSQVERLGELPRLYALLATRPAQLLNWAELSRASSLPATTLKRYFALLEALYLVRTLPPWQANLGKRLTKSPKVLPTDPGLALHAAGLDGARLEGDPILLGKYLEAFVAMEVVKQAGYAGVAVEVFHYRSHSGEEVDLVLEGPGGKVVGVEVKARGSLRPEDLRGLKSLAQALGPRFHRGVVLYLGRETVPFAKDLYALPLEALWRL
>NC_005838.1|WP_011174426.1|140034_143163_-|formate-dehydrogenase-accessory-sulfurtransferase-FdhD
MAWLNPFWSSPKAYVRPPKRGLAPELWASRIPFTHLENFYEVFRALWENRDNLPYAWRILKDGVCDGCALGTSGLEDWTLHGVHLCNVRLRLLRLNTLPPLDPKVLEDVEALKGRKSRELRRLGRLPYPMLRRKGERGFRRVSWDEALGLAAEYLRRHLPEGAFFYLTSRGVPNETYYVVQKAVRALGCNHVDNAARICHSPSTVVLKEALGVAATTCSYTDLIGTDLVVFLGSNVANNQPVMMKYLYHAKKAGTKVAVVNPYREPGMERYFVPSDLESALFGTRIADRFFQILPGGDIAFLHGAAKWMLEEGWVDPGFIRAHTAGFEAYKALLEAIPFAELEKAAGVSREEMRAFAEMVGRAERAVFVWGMGITQHTHGEDNVRAIVNLALLKGFVGREGCGLMPIRGHSGVQGGAEMGAYATAFPGGLPVNPENARRLAELWGFPVPDRPGLTTPEALDRALEGRLGVLWAIGGDFREVMPDPEAVEEALRRVPLRVHQDIVLSSQMLLEPGECVLLLPATTRYEVPGGVTETSTERRVIFSPEIPGPRPPEARPEWEVFQELVHRLRPELKDRFRFASTAEVREEIARVIPLYEGIQRLKAKGDQFQYGGRHLCEGWRFPTPDGKAHFRPVPPAPKGGPRGGLPRGHPPGEAVQLHRPRGPGPPHRGLPGRGLHEPQGRRPPGPEAWGSGGAGKRLRPLRRPGLPGGGQRGHPGGPLARGERPGRPQGPLPPGPHPGLQGGPRPPAAGGGGGPFPAPAMRGKARVRVARLEGGRWREVRDEVAAEAPLEIRLRYRDEVASLGVVLRTPGQDAELAAGLLYTEGLLQDPKEVLAIAPCADGSLPPEAREGVIQVFLRHPLPPPPKRHLALTAACGACGREALPDLGKLGLSPPPPLAVDPDLLLALPERLGEAQRLFRATGGLHAAALFDREGRLVALREDVGRHNALDKLIGWAFLQGKLPLHDHILLVSGRAGYELLVKAVAAGIPVFCAVSAPTSLAVALAQAYGLTLVGFLRPGRMNVYAGRERVGPPRGLPNPCG
>NC_005838.1|WP_011174427.1|139254_140007_-|LamB/YcsF-family-protein
MKVDLNADAGESYGAFAYGHDREIFPLVTSANLACGFHGGSPGRILEAVRLAKAHGVAVGAHPGFPDLVGFGRREMALSPEEVYADVLYQIGALSAFLKAEGLPLHHVKPHGALYLKACRDRETARAIALAVKAFDPGLPLVVLPGTVYEEEARKAGLRVVLEAFPERAYLRNGQLAPRSMPGSWITDPEEAARRALRMVLEGKVEALDGGEVAVRAETLCIHGDNPNAPEVARAVREALEQAGVEVRAF
>NC_005838.1|WP_148187583.1|137040_138195_+|type-I-C-CRISPR-associated-protein-Cas7/Csd2
MMSARYLDPKKRHEFVFLFDVRDGNPNGDPDAGNLPRVDPETMHGLVTDVALKRKIRDYIALTREGKPRFAIFVQSRVALNRLILEGFQEAGIEPVSLQLAEEQMANESLLEHLDGLAEAGFSREGGTLYYSGQATTEKEIAKLLMGEEEAVAPFKKELEKLAKELAKAVKGRKITEEDRERAQAKLLERFFDIRMFGAVLSTGLNAGQVRGPVQLTFARSLDPIAPLEVSITRVAITREEDRARKETEMGRKPLVPYGLYRAHGFFNPFLAAKTGVQPEDLEALWDALQHLFELDRSAARGEMTVRGLAVFSHEDAKGNAPAHRLFGLIRVERREGVEAPRSFADYRVRAPKEGSLEAHGFPGVHLAWLVRPEGLEDLPPHVG
>NC_005838.1|WP_011174415.1|154071_154275_+|AAA-associated-domain-containing-protein
MPLVKEIHRRVLAQGRLREEEALEALQARFPQAEARRVWRRLLEWSRFAGLFAYDESSRTLYPPGAA
>NC_005838.1|WP_011174414.1|154398_154719_+|antibiotic-biosynthesis-monooxygenase
MFVKMNRIPVRPEYAEQFEEAFRQRARLVDRMPGFIRNLVLRPKDPGDPYVVMTLWESEEAFRAWTESPAFKEGHARSGTLPKEAFLGPSRLEAFEVVLDSEGQDA
>NC_005838.1|WP_158300316.1|155019_155325_+|hypothetical-protein
MLAEAAEAYAGGPATEGLNRLRLLWLAARRPWEELEAFAFGPVGEFDPYLDTWSRACLANRLAPRRRGKEGEKNPKAVGDQLQRGPRHGRPRLPLHQVSPT
>NC_005838.1|WP_008633605.1|156057_156234_+|hypothetical-protein
MPKTKEPRLKALLKAPEWRRLAEAVALEPPEGPKPRFKPWRPRVKGVPLDAVLQDLRR
>NC_005838.1|WP_011174411.1|156489_158076_-|IS200/IS605-family-accessory-protein-TnpB-related-protein
MIGEAASQGRSRKRKKEKAFAGVHALLVFPSGEDRKATLDLMRRFSAAVHYAYNRLLQGWSREALKRENGPLCTFFRLNTRYADDAILKAQALLDSARERGEDPRKVVFGGRKLFETLKRGHLSGKPLKELKREWKEKRQGLLYSRGDKSKGGNLNLRLEAEDGALWLRVNLGNGSYAWALVKTSHPNLSALVERVHASLPYNVELSLKDGKVYATFTWEEEPTPLVATKENGVLGIDVNADPYHLALAVVGPNGNLRRHLTLSLEEVDRAPNRGAKELLLWKIAHQVVSLALEHGVAVATERLKHLPKGRRGDGSGRAFRRKQHRFAYASLLRKVHSLARKRGVQVVEVNPQDTSTIGMLKYAPQLSLSKDVAAAYVIGRRALGFKEKLPKGYGKLLRDERFRDHVQGFYASRVRELQAKKAQEQNPYLRRRLSREIGKAKRHLSLLSSLQGSPGSQREVTDGRNSPGANPWRVLRVGTFLPLLGREVPRDLSPLKPILFGGSWEGWRESRGPHPGGGPECTNVRST
>NC_005838.1|WP_011174410.1|158235_158691_-|PIN-domain-containing-protein
MPPSPVRLHRLFLDANVLFAACWQEGRAQALLELAPRAKVLLLTSPHALEEARRNLEAKRPEALECLQRIRERVQTVPEAPMALVQKALAEGLPLKDAPILAAAWKAGAEALVTGDRRHFGHLMGKRVRGLWVVSLAEALAGVMGLLEDKG
>NC_005838.1|WP_011174409.1|158671_158914_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein
MELAKLSRKGQLYIPKRLLKALGVEGEAYFLVELAPEGGLLLRPAGVYPLEVYTEERLQELLAEDTLTEEERARLAALAR
>NC_005838.1|WP_008630619.1|160288_160978_+|IS5-like-element-ISTth7-family-transposase
MRPSWRGFPGNWRPISPRSPRRKAKRLRTRRRHTWRRFPPLYLMDTTGLAYRSKDRLLRFRRGKEVRRVRGHARLLALMRWDRERRLLWPWGGVVGEGYAPDPRLGGEVLRRFPPSRGWLLADAGFDGKEVWGVLGEAGVRPVIRLRGGGEAREEARVRAREGWDPEVYRFRGVVEGVFGGMKTRLGGGYLWERKPWTAMARALLELIAYGLRVLLSLLPPPPGYKAIY
>NC_005838.1|WP_011174406.1|161358_161760_+|acyl-CoA-thioesterase
MRETRMVYPVFPGETNHYGTLFGGTVLAWMDQAAFVAATRHARKKVVTVHADAVDFKRPVPLGAIVELVARLKEVGRTSMRVEVEMWVEPVKEGEEAYLAARGGFVLVAVDEGGRPSPVPPLEGGEARAPHGP
>NC_005838.1|WP_011174405.1|161740_162715_+|ribonucleotide-diphosphate-reductase-subunit-beta
MPLTAPRLAYRPYEYPELLRFRDAIRHSYWVHTEFSFQSDLQDHALADEKERSLVERALLAIAQVELAVKLFWARVYDRFPKPEIAEVGLTFAESEVRHANAYAHLLELLGLEEAFGQALEGASALRDRAQALGEALRRAQGKDLREYALALFLFSAFTEHVSLFSQFYVLMALNRRGNRYKGISNAIEATSKEENVHGLFGVELLRLLRTEHPEALGEGFQEEALRLAQGLFRAEEALLDWLFSAGEPALVGHRETLEFLKGRYNQVLALHGLPPPFPVDEKALRDTEWFTLELLADKEVDFFNKRSVAYARRVQSFDPEELF

Crispr_ID: NC_005838_7

• CRISPR_ID: NC_005838_7
• CRISPR_location: 191888-192358
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 6 spacers
• Cas_protein_info: cas2,cas1,cas4,WYL,cas8b5,cas5,cas6

Consensus repeat of NC_005838_7

Consensus_repeat	Method
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	PILER-CR
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	CRISPRCasFinder
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	CRT

spacers of NC_005838_7

>7.1|191924|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT
ACCGCCACCGCCAAGATCCAAGCGCCCTGCATCCCT
>7.2|191996|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT
GATGGCGAGGACGGCCACGTTGAGGTCCCGGGCCAG
>7.3|192068|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT
GAGGGAGGCTGGTAGGACTCCATGCCGGGGTAGCGG
>7.4|192140|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT
TCTCCCTGGGCCGGATGCGGTGCCCCCTCCGGTCCCC
>7.5|192213|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT
CCTATCTCGTCTTCCGCCTCTGGAACTTCTCCGACAC
>7.6|192286|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT
TCAGTATACCACAGCTCTGCGGCGGGTGCTGGAGAAG

CRISPR arrays and Neighbor proteins around NC_005838_7

CRISPR arrays

The CRISPR arrays of NC_005838_7

>merge|NC_005838|7|191888-192358|PILER-CR,CRISPRCasFinder,CRT
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAACACCGCCACCGCCAAGATCCAAGCGCCCTGCATCCCTGTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAACGATGGCGAGGACGGCCACGTTGAGGTCCCGGGCCAGGTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAACGAGGGAGGCTGGTAGGACTCCATGCCGGGGTAGCGGGTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAACTCTCCCTGGGCCGGATGCGGTGCCCCCTCCGGTCCCCGTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAACCCTATCTCGTCTTCCGCCTCTGGAACTTCTCCGACACGTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAACTCAGTATACCACAGCTCTGCGGCGGGTGCTGGAGAAGGTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC

>NC_005838|7|7|191888-192358|PILER-CR
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	ACCGCCACCGCCAAGATCCAAGCGCCCTGCATCCCT
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	GATGGCGAGGACGGCCACGTTGAGGTCCCGGGCCAG
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	GAGGGAGGCTGGTAGGACTCCATGCCGGGGTAGCGG
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	TCTCCCTGGGCCGGATGCGGTGCCCCCTCCGGTCCCC
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	CCTATCTCGTCTTCCGCCTCTGGAACTTCTCCGACAC
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	TCAGTATACCACAGCTCTGCGGCGGGTGCTGGAGAAG
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC

>NC_005838|7|6|191888-192358|CRISPRCasFinder
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	ACCGCCACCGCCAAGATCCAAGCGCCCTGCATCCCT
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	GATGGCGAGGACGGCCACGTTGAGGTCCCGGGCCAG
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	GAGGGAGGCTGGTAGGACTCCATGCCGGGGTAGCGG
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	TCTCCCTGGGCCGGATGCGGTGCCCCCTCCGGTCCCC
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	CCTATCTCGTCTTCCGCCTCTGGAACTTCTCCGACAC
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	TCAGTATACCACAGCTCTGCGGCGGGTGCTGGAGAAG
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC

>NC_005838|7|6|191888-192358|CRT
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	ACCGCCACCGCCAAGATCCAAGCGCCCTGCATCCCT
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	GATGGCGAGGACGGCCACGTTGAGGTCCCGGGCCAG
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	GAGGGAGGCTGGTAGGACTCCATGCCGGGGTAGCGG
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	TCTCCCTGGGCCGGATGCGGTGCCCCCTCCGGTCCCC
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	CCTATCTCGTCTTCCGCCTCTGGAACTTCTCCGACAC
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	TCAGTATACCACAGCTCTGCGGCGGGTGCTGGAGAAG
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005838.1|WP_011174360.1|205467_206433_+|recombinase-XerD	unknown	unknown	gnl|CDD|227308
NC_005838.1|WP_011174383.1|181644_182043_-|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350249
NC_005838.1|WP_011174373.1|189588_189978_+|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|224761
NC_005838.1|WP_011174361.1|204973_205204_-|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NC_005838.1|WP_024118773.1|194795_195779_+|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl|CDD|379100
NC_005838.1|WP_041443960.1|189374_189602_+|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NC_005838.1|WP_148187587.1|187225_187594_-|pilus-assembly-protein-PilA	unknown	unknown	unknown
NC_005838.1|WP_011174370.1|192878_193856_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187766
NC_005838.1|WP_011174362.1|204563_204977_-|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|224761
NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_005838.1|WP_011174365.1|198858_199773_+|hypothetical-protein	cas5	cls000047_cas5_CAS-I-B	unknown
NC_005838.1|WP_011174369.1|193846_194431_-|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl|CDD|273040
NC_005838.1|WP_162467449.1|189983_190145_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_148187595.1|182035_182299_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	unknown	unknown	gnl|CDD|198034
NC_005838.1|WP_011174375.1|187659_189315_+|UvrD-helicase-domain-containing-protein	unknown	unknown	gnl|CDD|350194
NC_005838.1|WP_011174381.1|182599_182818_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_041443957.1|185358_187170_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174367.1|195796_198097_+|hypothetical-protein	cas8b5	mkCas0131_cas8b5_CAS-I-B	gnl|CDD|224117
NC_005838.1|WP_011174371.1|192597_192882_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856
NC_005838.1|WP_011174378.1|184912_185329_+|hypothetical-protein	unknown	unknown	unknown

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	1.3e-35	118.3	0.0
NC_005838.1|WP_011174365.1|198858_199773_+|hypothetical-protein	cas5	cls000047_cas5_CAS-I-B	4.4e-141	463.6	0.0
NC_005838.1|WP_011174370.1|192878_193856_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	1.7e-101	334.1	0.0
NC_005838.1|WP_024118773.1|194795_195779_+|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	2.7e-42	139.4	2.4
NC_005838.1|WP_011174371.1|192597_192882_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	3.6e-24	79.5	0.0
NC_005838.1|WP_011174367.1|195796_198097_+|hypothetical-protein	cas8b5	mkCas0131_cas8b5_CAS-I-B	5.3e-289	955.4	0.0
NC_005838.1|WP_011174369.1|193846_194431_-|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	5.7e-36	119.1	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005838.1|WP_011174360.1|205467_206433_+|recombinase-XerD	gnl|CDD|227308	COG4974, XerD, Site-specific recombinase XerD [DNA replication, recombination, and repair].	6.9815e-08
NC_005838.1|WP_011174383.1|181644_182043_-|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350249	cd18682, PIN_VapC-like, Uncharacterized subfamily of the VapC (virulence-associated protein C)-like family of the PIN domain superfamily. VapC is the PIN-domain ribonuclease toxin from prokaryotic VapBC toxin-antitoxin (TA) systems. VapB is a transcription factor-like protein antitoxin acting as an inhibitor. Other members of the VapC-like nuclease family include FitB toxin of the FitAB TA system, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and rRNA-processing protein Fcf1. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	4.96205e-48
NC_005838.1|WP_011174373.1|189588_189978_+|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|224761	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only].	5.83167e-11
NC_005838.1|WP_024118773.1|194795_195779_+|WYL-domain-containing-protein	gnl|CDD|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	2.4479e-40
NC_005838.1|WP_011174362.1|204563_204977_-|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|224761	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only].	3.54521e-07
NC_005838.1|WP_011174370.1|192878_193856_-|CRISPR-associated-endonuclease-Cas1	gnl|CDD|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	4.88175e-114
NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	3.73308e-33
NC_005838.1|WP_011174369.1|193846_194431_-|CRISPR-associated-protein-Cas4	gnl|CDD|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	1.57413e-35
NC_005838.1|WP_148187595.1|182035_182299_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein	gnl|CDD|198034	smart00966, SpoVT_AbrB, SpoVT / AbrB like domain. This domain is found in AbrB from Bacillus subtilis. The product of the abrB gene is an ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. AbrB is thought to interact directly with the transcription initiation regions of genes under its control. AbrB contains a helix-turn-helix structure, but this domain ends before the helix-turn-helix begins. The product of the B. subtilis gene spoVT is another member of this family and is also a transcriptional regulator. DNA-binding activity in this AbrB homologue requires hexamerisation. Another family member has been isolated from the Sulfolobus solfataricus and has been identified as a homologue of bacterial repressor-like proteins. The Escherichia coli family member SohA or Prl1F appears to be bifunctional and is able to regulate its own expression as well as relieve the export block imposed by high-level synthesis of beta-galactosidase hybrid proteins.	4.64136e-05
NC_005838.1|WP_011174375.1|187659_189315_+|UvrD-helicase-domain-containing-protein	gnl|CDD|350194	cd18807, SF1_C_UvrD, C-terminal helicase domain of UvrD family helicases. UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.	1.50983e-11
NC_005838.1|WP_011174367.1|195796_198097_+|hypothetical-protein	gnl|CDD|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	9.92343e-05
NC_005838.1|WP_011174371.1|192597_192882_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.78454e-25

Protein sequences

>NC_005838.1|WP_162467449.1|189983_190145_-|hypothetical-protein
MGEGLGLREARLRRKERTAEAQLVRSPVSGRVVEVKVRDLRPGEVVVEVVVAR
>NC_005838.1|WP_011174373.1|189588_189978_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MTALDTGFFLRLLEGHEEAGALWRALAEGEGEGVVSGLSLVELLRLGLKGALAKEDAELLLQAIPAVCRVVWPDWTTGERAARLSHGLYLPLVDALVLATALEAGARELWTTDADLGRYEGKLRVVLLR
>NC_005838.1|WP_041443960.1|189374_189602_+|ribbon-helix-helix-protein,-CopG-family
MRLTVHIPEDLARLLRQAAENEGKSMSALTAEALEAYLKERRRRALGLKVLERAGKGRVAGEAHRLLEEGRRDRP
>NC_005838.1|WP_011174375.1|187659_189315_+|UvrD-helicase-domain-containing-protein
MALRPTEEQLKAVEAYRSGQDLKVVAVAGSGKTTTLRLMAEATPGKRGLYLAFNRSVQQEAARKFPRNVRPYTLHALAFRMAVARDEGYRAKFQAGKGHLPAQAVAEALGLRNPLLLHAVLGTLEAFLRSEAASPDPGMIPLAYRTLRAGTKTWPEEEAFVLRGVEALWRRMTDPKDPFPLPHGAYVKLWALSEPDLSFAEALLVDEAQDLDPIFLKVLEAHRGRVQRVYVGDPRQQIYGWRGAINAMDRLEAPEARLTWSFRFAETLARFVRNLTALQDRPVEVRGKAPWATRVDAALPRPPFTVLCRTNAGVVGAVVVTHEVHRGRVHVVGGVEELVHLLRDAALLKKGEKRTDPHPDLAMVETWEELEALAEAGYAPAYGVLRLAQEHPDLEALAAYLERAWTPVEVAAGVVVSTAHKAKGREWDRVVLWDDFYPWWEEGAAARVNWGSDPAHLEEENLLYVAATRARKHLSLAQIRDLLEAVDRMGVYRVAEEATRAYLLLSAEVLRGVATDPRVPAEHRVRALKALGYLERGEEALDSPGKPGGQG
>NC_005838.1|WP_148187587.1|187225_187594_-|pilus-assembly-protein-PilA
MGKTAGGRPLEANRRSSNDTIVQSYLREVQKYQEMYYGFNRRYAQNLAQLKALVPPIEDPPTNPPVTVRFVTTGVDYNREYCVVAGTNVGQYWYQATSKGVRVRTDAPATGAAPTSCDFTLY
>NC_005838.1|WP_041443957.1|185358_187170_+|hypothetical-protein
MRENVRKTVRNAALLLALGLLAGCNLNGGGAPKYELVDENGNPYCGGRLGGVPELTLRISDSSPPLFPDRQYVEVDFPWVSTGFGNHVHPNYQQGVLPNGLVPLVSYFEYYTDTSGVEHPFAPPIVSGWWNPPRADYETLPNGQIWTRHGTLVALLDPNSMRVVRASVYGWANNSWPTAYAAGSDGYLYLAGTTADARRMGDGTGGWDYSYAPESGSEVFLTKIDPETMEPAWVARLRISDFGALREWDRDITALSVLYDPSTDTVLVGTTQAPSGEGNVFRVRASDGEVLSMFTTIYGAEWLYWAEGGPASQTVYVGGSNKVCWGSACYLFRGGVAAEKYRLPPASGTGLQRPPLLWEVKAFDVAYEYLGSAGGQDFFQEWDTRGMVETSMMTPAPEGGLNFHVDFFAEISNVDFSRYHLFKEKAKEGWENRGVIGYLGRISPDGELQVQEENLIPVKKPVDETWVSQASAALFLNVNGRTAVLYGVGGPFAPCYYQYVMESGKDGELNVPEKLGGPYGFILKRDWTPGEKVTGPDVIPHTNLSEWRELGRLINPVILLHFLRHIPLPDGGNVVYMAGYGGRGNNPLGVNEAAFKVVRFDVR
>NC_005838.1|WP_011174378.1|184912_185329_+|hypothetical-protein
MDTFVWSGGDVTLAGSVRTTPNACALYTPTVGAPPDVNCARDPKAVRFHLDAGESGTITLTGLPSTVLGFLAGRRLVAAQENLTVRVVGGAHLVEGFSGSFQFYHDPNYTENLNIVAVLSPAKEYAVVKTAPPSPWSP
>NC_005838.1|WP_011174381.1|182599_182818_+|hypothetical-protein
MADFLNHVVVEHLLKDATLGYVRVGRNLKEVPILSEEAIQILERLAQKLPPVHTPPDDAPSEPWWRRLRRKR
>NC_005838.1|WP_148187595.1|182035_182299_-|AbrB/MazE/SpoVT-family-DNA-binding-domain-containing-protein
MILMVKKAHSTTLTLDAQGRVLLPRPLRQALGLGPGARLVALVEDGRLVLTPWERLEEELWAELADVQESLAEELLRERRLEAEKDA
>NC_005838.1|WP_011174383.1|181644_182043_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MPEGPRKLLDASALLAYLQRELGFEAVREALREGAAISAVNLAEVAGKLKARGKDPERIVRRLLAMGLEVLPFTLEEALEAGALDPLTRPLGLSLGDRACLAAGRVRGLAVLTADRTWAGVDLGVPVEVIRP
>NC_005838.1|WP_011174371.1|192597_192882_-|CRISPR-associated-endonuclease-Cas2
MRELYLVIAYDTPDDRRRARLAKLLKGFGERRQYSVFEARLTREQWAHLKGKLEALVNKEEDVLAVYFLPPEAVGRTWRIGHEGLKRLEDPDFV
>NC_005838.1|WP_011174370.1|192878_193856_-|CRISPR-associated-endonuclease-Cas1
MGVVYVLENEAYLSKEGGTLKVSRRAGREVLLQKPLIAVEEIVILGNAVVTPALLKHCAQEGVGIHYLSPTGTYYAGLTRTPSKNAPARVAQFKAYLEPTWKLALAQRFVLGKIRNGLVFLRRNGAEGWERLKEALLEAERAQDEEALRGAEGRAADLYFRAFAELLPEEFAFGERSRRPPRDPANSLLSLAYTLLAKECESALLVAGLDPYVGYLHEVRYGRPSLALDLMEEFRSVLADSVVLSLLNNRRVTLEDFDDSEGFPRLRKEAWPKFLRAWEERLNERVQHPLLRKRLAYREILLAQARILVKHLLGELPRYEPFAVR
>NC_005838.1|WP_011174369.1|193846_194431_-|CRISPR-associated-protein-Cas4
MGHGGAVEYLPLSKVNTVVYCPRRFYLEYVLGEAHANHHLIEGHYLHERAYTEPGEESGLWVWSDRLGLLGVVDRLEWRRGEACPVEYKLGRAKEEAYLSDAVQLAAQALCLRESRGIKARRGFVYYHKSHTRREVVFTPELFRAVEAAVVRMRALLQSPRPPRVEVPPSKCEGCSVQGACQPELWRKGVAGWA
>NC_005838.1|WP_024118773.1|194795_195779_+|WYL-domain-containing-protein
MESRLPDFLRLLRESPKGLPVREIAARLGVRRQSVYRLRDKAQSLGVWVETHGENPEVPPGWMRLEAPLEVTVRLTLEEAEALRAAVERMEPLTPLAKRALERLALRTLAAPGKDRQDPVVYTPLADEYPPGLFERAVRAIRERRTCQVTYKNAKGEVKTYRFDPYALIARDPHLYLVGANHNSRRAGHDPVKDLRLDQILDLRLTRERFRKPRFDVRAYAQRRFRAFAGEGAPVRVRVRFSPEKAGFIRRTRRHPTQVVEDLPDGSVVWQVEVPLSEDLVHFIVGYGPHATVLEPEELRRRVVAWAKGAVAANEGVLSPEGVTGLD
>NC_005838.1|WP_011174367.1|195796_198097_+|hypothetical-protein
MERAMVQASTVARAKRLVADVRFGEAPREALLAYKEALDEPEFAAFLERIDPRIVRYLRVAPGGSQALSDPKGKDLLLYLHPLPGERQMRAAYEVAIEGFLEHLEAKGYPVVERGAGWVKAYVSPKAPSLDLEGAWKAYIEEAFSLEGLSARLLPLLNSVRLAGRGISAPKVPVPTLGARDFLAAWYLANLLSVKERLAWRDQEIRRLEEEASRLPEGSEKSRKLRELEKRRQDQEKELKKYGGELRKKWEEIVREEEKRAEKRRKLEERLQRAKPKDRPRLENELRALEPPLAQWALKGLGQAKDDPGRLWTWLDPESPEAPGAIQRLKPYLGRFGPLAKGQLNTAVGNKFTKILEELLRLLSLSSPEVEVPPLVSETPFTLDLRDPGDKADVCYGCGRPLGKDKLKASKLVFASPSQRLQSGNGQEEPWVCPSCAALALLSPIKPGEGSVLVQVGSYGAPEAAKHFARLLVTGTLHVAAGRYLLLNSPQVGGKPLAQALGRVVYALQALGQEVNPKVLERFPFYLVEGAQEIPLPPRALWLSHVLQRAFASRPDEGGEVNRPLGEALRYALGDLPWHALYTLARRYGRVADRFSLEDGLMRYASLLEKEVGMKENTDLSQRFRDVAGLTGLLSAWVGYVEGQVGRNSQEAKRAVVKLLDNLERPGDFLYVAAYHLDSTQARLYEAGGAFFYQEAKRLLQEAGARAQEAEEGSGRFLNVSQDDLHRVYAHLAARYPGKAWEGFIYEVRLSLASRFPQYIRMEKEG
>NC_005838.1|WP_011174365.1|198858_199773_+|hypothetical-protein
MPPKEKRFSSATGGGRPWRRFGGWPRLLWRRTFRLWLPLPNMHAIALRIRPTSALTFRVLPGSILDIATYPFVPPTTLSGWLRRLFWAQKGLLPPDQREGNTPRFYVLPRRYLPLGAYPVGEWRVHRTHRHGPRAFTHSEFSRLRREGKPPKGGDLQLHTWEYLLAEEFLGAVLAEKEEDLRRLQGLVGYGAKLGKEGFAYLEAVGEPLEVRLEEGDAPFTPVRAEAWGGAIQGAYPLYRFRFGEAEDPDPASPDPSPVIGYEGAYFVLPRGRGLAKGFSLEGRFFAWDLVEFLWARASGGSSS
>NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6
MPQAVVLELVGEKPPLYPARYAHGLFFALLSRVSPELAQKLHEAPRKPFTLAPLPRAGPEGATLKGTLRLRLTTLDDGLFAPFLRALLEAAPDGLPLGDSSYRLARVLATREGHPLAGATSWEELKEAPKREKVTFRFLTPTVFATSKPGGRTRYTPLPDPRLIAGSLLDKWQAHSPFPYNPKEEAALRGLFELDLEVAGFRNLRFHRVQAGKGFFPGFTGEMTLRLWSQSLEAREALGRLHALAFFSGVGAKTPYGMGLAVPL
>NC_005838.1|WP_011174362.1|204563_204977_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MIPERLVLDAGPLIALLHRSDPDHEEAVRGFRRLAEGGARLFLPMPVLFEVFKWLLFQAGPKAAREGLAKVEEGAVVVPFTLEDLEEVRLLLARLPGWGGTLEDAGVALLALRLGAPVWTLNYRDLGAFPALRFWTP
>NC_005838.1|WP_011174361.1|204973_205204_-|ribbon-helix-helix-protein,-CopG-family
MMMCDMRVTIYLPDHLAQEVEAYRKARPGLSLSALVRELLERELVKRPEALLEVAGLVEKAELSAREHDALIREER
>NC_005838.1|WP_011174360.1|205467_206433_+|recombinase-XerD
MREGLGLEVWDHPEERRRVVGEALARWDEALLKEALWAYLVRHRKKPDRVAPHYVGYFVRWLALKGRRWPHLEPEDPKAFLLEAKEKGFPGGERGPMAWSTVERARASLRHLFPFLDWAGHPMPSHVRLPSRQELPVVAPSRAMPEEAYRDLLEKAGAYPLAYWRPLLRVLLVLLGEVGLTVKEAVELWQEDVREKVLLVRGTKLREVPLSPLAREVLADWLPQRAFLASHQPLPYPHLLLKPAPGKNRGKPLGLEEAKWILTEFADFAGVKAEGKKRADLALPLRWRAIRRFLKEGHPREKVAYWTGMKSLVVPGWGEEG

Crispr_ID: NC_005838_8

• CRISPR_ID: NC_005838_8
• CRISPR_location: 203222-204195
• CRISPR_type: Unclear
• Repeat_type: NA
• Spacer_info: 13 spacers
• Cas_protein_info: cas6,cas5,cas8b5,WYL,cas4,cas1,cas2

Consensus repeat of NC_005838_8

Consensus_repeat	Method
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CRISPRCasFinder
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CRT
GTTTCAATCCTCTACGAGGCTAACGAGGTTTGCAAC	PILER-CR

spacers of NC_005838_8

>8.1|203258|36|NC_005838|CRISPRCasFinder,CRT
TCCGGCTCGTGAACGGCGAGATTCAGATCATTCCCG
>8.2|203330|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR
CATCACCTCGGCCCGGGCCAGGACCACCCCCACCC
>8.3|203401|38|NC_005838|CRISPRCasFinder,CRT,PILER-CR
CCGCCTGGCTCGCCGGCCCCATCGCCCGCCTCTGGCAG
>8.4|203475|36|NC_005838|CRISPRCasFinder,CRT,PILER-CR
CGCTATGGACCGAAACGACTGCCCACTCGCGAGCGC
>8.5|203547|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR
AACACAGCGTAGACCGTAACGGCCCCCAGCGCGATGC
>8.6|203620|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR
CCGAACCGCCGCCTCAGCGCGGTGAGGACCTCGCCCA
>8.7|203693|34|NC_005838|CRISPRCasFinder,CRT,PILER-CR
GTGCGGCTCGTGACCAAGTAGCCATGGGGTACTT
>8.8|203763|36|NC_005838|CRISPRCasFinder,CRT,PILER-CR
TTCGGAACCCGCCTGGAGTACGCCCCATATCAGCAG
>8.9|203835|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR
CGCTGGGCGGGGATCGCGGCGAGCGTGGTCCTCCC
>8.10|203906|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR
TGTACGCCCTGCGAAACTTTGTGCTCCAAAGCGTGGT
>8.11|203979|38|NC_005838|CRISPRCasFinder,CRT,PILER-CR
AGGGCCTCGAGGCCCTTCACCAGGAGGCCGAGGCGGCG
>8.12|204053|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR
CTGAGGGAGCTGGTAAACGAGCTTGGGAACGCCTG
>8.13|204124|36|NC_005838|CRISPRCasFinder,CRT
ATTCGCCGCCTCCCAGTAGCCGCGCCACCACCTCAG

CRISPR arrays and Neighbor proteins around NC_005838_8

CRISPR arrays

The CRISPR arrays of NC_005838_8

>merge|NC_005838|8|203222-204195|CRISPRCasFinder,CRT,PILER-CR
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACTCCGGCTCGTGAACGGCGAGATTCAGATCATTCCCGGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACCATCACCTCGGCCCGGGCCAGGACCACCCCCACCCGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACCCGCCTGGCTCGCCGGCCCCATCGCCCGCCTCTGGCAGGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACCGCTATGGACCGAAACGACTGCCCACTCGCGAGCGCGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACAACACAGCGTAGACCGTAACGGCCCCCAGCGCGATGCGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACCCGAACCGCCGCCTCAGCGCGGTGAGGACCTCGCCCAGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACGTGCGGCTCGTGACCAAGTAGCCATGGGGTACTTGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACTTCGGAACCCGCCTGGAGTACGCCCCATATCAGCAGGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACCGCTGGGCGGGGATCGCGGCGAGCGTGGTCCTCCCGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACTGTACGCCCTGCGAAACTTTGTGCTCCAAAGCGTGGTGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACAGGGCCTCGAGGCCCTTCACCAGGAGGCCGAGGCGGCGGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACCTGAGGGAGCTGGTAAACGAGCTTGGGAACGCCTGGTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAACATTCGCCGCCTCCCAGTAGCCGCGCCACCACCTCAGGTTGCAAACCTCTTTAGCCTCGTAGAGGATTGATAC

>NC_005838|8|7|203222-204195|CRISPRCasFinder
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	TCCGGCTCGTGAACGGCGAGATTCAGATCATTCCCG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CATCACCTCGGCCCGGGCCAGGACCACCCCCACCC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CCGCCTGGCTCGCCGGCCCCATCGCCCGCCTCTGGCAG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CGCTATGGACCGAAACGACTGCCCACTCGCGAGCGC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	AACACAGCGTAGACCGTAACGGCCCCCAGCGCGATGC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CCGAACCGCCGCCTCAGCGCGGTGAGGACCTCGCCCA
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	GTGCGGCTCGTGACCAAGTAGCCATGGGGTACTT
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	TTCGGAACCCGCCTGGAGTACGCCCCATATCAGCAG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CGCTGGGCGGGGATCGCGGCGAGCGTGGTCCTCCC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	TGTACGCCCTGCGAAACTTTGTGCTCCAAAGCGTGGT
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	AGGGCCTCGAGGCCCTTCACCAGGAGGCCGAGGCGGCG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CTGAGGGAGCTGGTAAACGAGCTTGGGAACGCCTG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	ATTCGCCGCCTCCCAGTAGCCGCGCCACCACCTCAG
GTTGCAAACCTCTTTAGCCTCGTAGAGGATTGATAC

>NC_005838|8|7|203222-204195|CRT
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	TCCGGCTCGTGAACGGCGAGATTCAGATCATTCCCG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CATCACCTCGGCCCGGGCCAGGACCACCCCCACCC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CCGCCTGGCTCGCCGGCCCCATCGCCCGCCTCTGGCAG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CGCTATGGACCGAAACGACTGCCCACTCGCGAGCGC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	AACACAGCGTAGACCGTAACGGCCCCCAGCGCGATGC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CCGAACCGCCGCCTCAGCGCGGTGAGGACCTCGCCCA
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	GTGCGGCTCGTGACCAAGTAGCCATGGGGTACTT
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	TTCGGAACCCGCCTGGAGTACGCCCCATATCAGCAG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CGCTGGGCGGGGATCGCGGCGAGCGTGGTCCTCCC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	TGTACGCCCTGCGAAACTTTGTGCTCCAAAGCGTGGT
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	AGGGCCTCGAGGCCCTTCACCAGGAGGCCGAGGCGGCG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CTGAGGGAGCTGGTAAACGAGCTTGGGAACGCCTG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	ATTCGCCGCCTCCCAGTAGCCGCGCCACCACCTCAG
GTTGCAAACCTCTTTAGCCTCGTAGAGGATTGATAC

>NC_005838|8|8|203294-204123|PILER-CR
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CATCACCTCGGCCCGGGCCAGGACCACCCCCACCC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CCGCCTGGCTCGCCGGCCCCATCGCCCGCCTCTGGCAG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CGCTATGGACCGAAACGACTGCCCACTCGCGAGCGC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	AACACAGCGTAGACCGTAACGGCCCCCAGCGCGATGC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CCGAACCGCCGCCTCAGCGCGGTGAGGACCTCGCCCA
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	GTGCGGCTCGTGACCAAGTAGCCATGGGGTACTT
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	TTCGGAACCCGCCTGGAGTACGCCCCATATCAGCAG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CGCTGGGCGGGGATCGCGGCGAGCGTGGTCCTCCC
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	TGTACGCCCTGCGAAACTTTGTGCTCCAAAGCGTGGT
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	AGGGCCTCGAGGCCCTTCACCAGGAGGCCGAGGCGGCG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC	CTGAGGGAGCTGGTAAACGAGCTTGGGAACGCCTG
GTTGCAAACCTCGTTAGCCTCGTAGAGGATTGAAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005838.1|WP_011174360.1|205467_206433_+|recombinase-XerD	unknown	unknown	gnl|CDD|227308
NC_005838.1|WP_014511095.1|206966_207116_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174373.1|189588_189978_+|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|224761
NC_005838.1|WP_011174361.1|204973_205204_-|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NC_005838.1|WP_011173580.1|211679_212633_+|IS110-family-transposase	unknown	unknown	gnl|CDD|376564
NC_005838.1|WP_024118773.1|194795_195779_+|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	gnl|CDD|379100
NC_005838.1|WP_011174357.1|209852_211073_-|ATP-binding-protein	unknown	unknown	gnl|CDD|224292
NC_005838.1|WP_011174362.1|204563_204977_-|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|224761
NC_005838.1|WP_011174370.1|192878_193856_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187766
NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_005838.1|WP_011174365.1|198858_199773_+|hypothetical-protein	cas5	cls000047_cas5_CAS-I-B	unknown
NC_005838.1|WP_041443967.1|209336_209534_-|hypothetical-protein	unknown	unknown	gnl|CDD|379248
NC_005838.1|WP_162467440.1|213421_213661_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174369.1|193846_194431_-|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	gnl|CDD|273040
NC_005838.1|WP_162467449.1|189983_190145_-|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_041443960.1|189374_189602_+|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NC_005838.1|WP_011174359.1|207112_207583_+|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350222
NC_005838.1|WP_011174358.1|207698_209327_-|IS1634-like-element-ISTth3-family-transposase	unknown	unknown	gnl|CDD|227708
NC_005838.1|WP_011174367.1|195796_198097_+|hypothetical-protein	cas8b5	mkCas0131_cas8b5_CAS-I-B	gnl|CDD|224117
NC_005838.1|WP_011174371.1|192597_192882_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	gnl|CDD|187856

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	1.3e-35	118.3	0.0
NC_005838.1|WP_011174365.1|198858_199773_+|hypothetical-protein	cas5	cls000047_cas5_CAS-I-B	4.4e-141	463.6	0.0
NC_005838.1|WP_011174370.1|192878_193856_-|CRISPR-associated-endonuclease-Cas1	cas1	cd09634_cas1_CAS-I:CAS-II:CAS-III:CAS-V	1.7e-101	334.1	0.0
NC_005838.1|WP_024118773.1|194795_195779_+|WYL-domain-containing-protein	WYL	pfam13280_WYL_CAS-I:CAS-III	2.7e-42	139.4	2.4
NC_005838.1|WP_011174371.1|192597_192882_-|CRISPR-associated-endonuclease-Cas2	cas2	cd09725_cas2_CAS-I:CAS-II:CAS-III:CAS-V	3.6e-24	79.5	0.0
NC_005838.1|WP_011174367.1|195796_198097_+|hypothetical-protein	cas8b5	mkCas0131_cas8b5_CAS-I-B	5.3e-289	955.4	0.0
NC_005838.1|WP_011174369.1|193846_194431_-|CRISPR-associated-protein-Cas4	cas4	cd09637_cas4_CAS-I:CAS-II:CAS-V	5.7e-36	119.1	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005838.1|WP_011174360.1|205467_206433_+|recombinase-XerD	gnl|CDD|227308	COG4974, XerD, Site-specific recombinase XerD [DNA replication, recombination, and repair].	6.9815e-08
NC_005838.1|WP_011174358.1|207698_209327_-|IS1634-like-element-ISTth3-family-transposase	gnl|CDD|227708	COG5421, COG5421, Transposase [DNA replication, recombination, and repair].	2.69938e-55
NC_005838.1|WP_011174373.1|189588_189978_+|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|224761	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only].	5.83167e-11
NC_005838.1|WP_011173580.1|211679_212633_+|IS110-family-transposase	gnl|CDD|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	2.18932e-28
NC_005838.1|WP_024118773.1|194795_195779_+|WYL-domain-containing-protein	gnl|CDD|379100	pfam13280, WYL, WYL domain. WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.	2.4479e-40
NC_005838.1|WP_011174357.1|209852_211073_-|ATP-binding-protein	gnl|CDD|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	1.23209e-59
NC_005838.1|WP_011174369.1|193846_194431_-|CRISPR-associated-protein-Cas4	gnl|CDD|273040	TIGR00372, conserved_hypothetical_protein, CRISPR-associated protein Cas4. This model represents a family of proteins associated with CRISPR repeats in a wide set of prokaryotic genomes. This scope of this model has been broadened since it was first built to describe an archaeal subset only. The function of the protein is undefined. Distantly related proteins, excluded from this model, include ORFs from Mycobacteriophage D29 and Sulfolobus islandicus filamentous virus and a region of the Schizosaccharomyces pombe DNA replication helicase Dna2p.	1.57413e-35
NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	3.73308e-33
NC_005838.1|WP_041443967.1|209336_209534_-|hypothetical-protein	gnl|CDD|379248	pfam13540, RCC1_2, Regulator of chromosome condensation (RCC1) repeat.	2.4553e-05
NC_005838.1|WP_011174370.1|192878_193856_-|CRISPR-associated-endonuclease-Cas1	gnl|CDD|187766	cd09634, Cas1_I-II-III, CRISPR/Cas system-associated protein Cas1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas1 is the most universal CRISPR system protein thought to be involved in spacer integration; Cas1 is metal-dependent deoxyribonuclease, also binds RNA; Shown to possess a unique fold consisting of a N-terminal beta-strand domain and a C-terminal alpha-helical domain.	4.88175e-114
NC_005838.1|WP_011174362.1|204563_204977_-|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|224761	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only].	3.54521e-07
NC_005838.1|WP_011174359.1|207112_207583_+|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350222	cd09874, PIN_MT3492-like, VapC-like PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis CDC1551, hypothetical protein MT3492, and similar bacterial and archaeal proteins are included in this subfamily. They are PIN domain homologs of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	3.88829e-26
NC_005838.1|WP_011174367.1|195796_198097_+|hypothetical-protein	gnl|CDD|224117	COG1196, Smc, Chromosome segregation ATPases [Cell division and chromosome partitioning].	9.92343e-05
NC_005838.1|WP_011174371.1|192597_192882_-|CRISPR-associated-endonuclease-Cas2	gnl|CDD|187856	cd09725, Cas2_I_II_III, CRISPR/Cas system-associated protein Cas2. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold.	1.78454e-25

Protein sequences

>NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6
MPQAVVLELVGEKPPLYPARYAHGLFFALLSRVSPELAQKLHEAPRKPFTLAPLPRAGPEGATLKGTLRLRLTTLDDGLFAPFLRALLEAAPDGLPLGDSSYRLARVLATREGHPLAGATSWEELKEAPKREKVTFRFLTPTVFATSKPGGRTRYTPLPDPRLIAGSLLDKWQAHSPFPYNPKEEAALRGLFELDLEVAGFRNLRFHRVQAGKGFFPGFTGEMTLRLWSQSLEAREALGRLHALAFFSGVGAKTPYGMGLAVPL
>NC_005838.1|WP_011174365.1|198858_199773_+|hypothetical-protein
MPPKEKRFSSATGGGRPWRRFGGWPRLLWRRTFRLWLPLPNMHAIALRIRPTSALTFRVLPGSILDIATYPFVPPTTLSGWLRRLFWAQKGLLPPDQREGNTPRFYVLPRRYLPLGAYPVGEWRVHRTHRHGPRAFTHSEFSRLRREGKPPKGGDLQLHTWEYLLAEEFLGAVLAEKEEDLRRLQGLVGYGAKLGKEGFAYLEAVGEPLEVRLEEGDAPFTPVRAEAWGGAIQGAYPLYRFRFGEAEDPDPASPDPSPVIGYEGAYFVLPRGRGLAKGFSLEGRFFAWDLVEFLWARASGGSSS
>NC_005838.1|WP_011174367.1|195796_198097_+|hypothetical-protein
MERAMVQASTVARAKRLVADVRFGEAPREALLAYKEALDEPEFAAFLERIDPRIVRYLRVAPGGSQALSDPKGKDLLLYLHPLPGERQMRAAYEVAIEGFLEHLEAKGYPVVERGAGWVKAYVSPKAPSLDLEGAWKAYIEEAFSLEGLSARLLPLLNSVRLAGRGISAPKVPVPTLGARDFLAAWYLANLLSVKERLAWRDQEIRRLEEEASRLPEGSEKSRKLRELEKRRQDQEKELKKYGGELRKKWEEIVREEEKRAEKRRKLEERLQRAKPKDRPRLENELRALEPPLAQWALKGLGQAKDDPGRLWTWLDPESPEAPGAIQRLKPYLGRFGPLAKGQLNTAVGNKFTKILEELLRLLSLSSPEVEVPPLVSETPFTLDLRDPGDKADVCYGCGRPLGKDKLKASKLVFASPSQRLQSGNGQEEPWVCPSCAALALLSPIKPGEGSVLVQVGSYGAPEAAKHFARLLVTGTLHVAAGRYLLLNSPQVGGKPLAQALGRVVYALQALGQEVNPKVLERFPFYLVEGAQEIPLPPRALWLSHVLQRAFASRPDEGGEVNRPLGEALRYALGDLPWHALYTLARRYGRVADRFSLEDGLMRYASLLEKEVGMKENTDLSQRFRDVAGLTGLLSAWVGYVEGQVGRNSQEAKRAVVKLLDNLERPGDFLYVAAYHLDSTQARLYEAGGAFFYQEAKRLLQEAGARAQEAEEGSGRFLNVSQDDLHRVYAHLAARYPGKAWEGFIYEVRLSLASRFPQYIRMEKEG
>NC_005838.1|WP_024118773.1|194795_195779_+|WYL-domain-containing-protein
MESRLPDFLRLLRESPKGLPVREIAARLGVRRQSVYRLRDKAQSLGVWVETHGENPEVPPGWMRLEAPLEVTVRLTLEEAEALRAAVERMEPLTPLAKRALERLALRTLAAPGKDRQDPVVYTPLADEYPPGLFERAVRAIRERRTCQVTYKNAKGEVKTYRFDPYALIARDPHLYLVGANHNSRRAGHDPVKDLRLDQILDLRLTRERFRKPRFDVRAYAQRRFRAFAGEGAPVRVRVRFSPEKAGFIRRTRRHPTQVVEDLPDGSVVWQVEVPLSEDLVHFIVGYGPHATVLEPEELRRRVVAWAKGAVAANEGVLSPEGVTGLD
>NC_005838.1|WP_011174369.1|193846_194431_-|CRISPR-associated-protein-Cas4
MGHGGAVEYLPLSKVNTVVYCPRRFYLEYVLGEAHANHHLIEGHYLHERAYTEPGEESGLWVWSDRLGLLGVVDRLEWRRGEACPVEYKLGRAKEEAYLSDAVQLAAQALCLRESRGIKARRGFVYYHKSHTRREVVFTPELFRAVEAAVVRMRALLQSPRPPRVEVPPSKCEGCSVQGACQPELWRKGVAGWA
>NC_005838.1|WP_011174370.1|192878_193856_-|CRISPR-associated-endonuclease-Cas1
MGVVYVLENEAYLSKEGGTLKVSRRAGREVLLQKPLIAVEEIVILGNAVVTPALLKHCAQEGVGIHYLSPTGTYYAGLTRTPSKNAPARVAQFKAYLEPTWKLALAQRFVLGKIRNGLVFLRRNGAEGWERLKEALLEAERAQDEEALRGAEGRAADLYFRAFAELLPEEFAFGERSRRPPRDPANSLLSLAYTLLAKECESALLVAGLDPYVGYLHEVRYGRPSLALDLMEEFRSVLADSVVLSLLNNRRVTLEDFDDSEGFPRLRKEAWPKFLRAWEERLNERVQHPLLRKRLAYREILLAQARILVKHLLGELPRYEPFAVR
>NC_005838.1|WP_011174371.1|192597_192882_-|CRISPR-associated-endonuclease-Cas2
MRELYLVIAYDTPDDRRRARLAKLLKGFGERRQYSVFEARLTREQWAHLKGKLEALVNKEEDVLAVYFLPPEAVGRTWRIGHEGLKRLEDPDFV
>NC_005838.1|WP_162467449.1|189983_190145_-|hypothetical-protein
MGEGLGLREARLRRKERTAEAQLVRSPVSGRVVEVKVRDLRPGEVVVEVVVAR
>NC_005838.1|WP_011174373.1|189588_189978_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MTALDTGFFLRLLEGHEEAGALWRALAEGEGEGVVSGLSLVELLRLGLKGALAKEDAELLLQAIPAVCRVVWPDWTTGERAARLSHGLYLPLVDALVLATALEAGARELWTTDADLGRYEGKLRVVLLR
>NC_005838.1|WP_041443960.1|189374_189602_+|ribbon-helix-helix-protein,-CopG-family
MRLTVHIPEDLARLLRQAAENEGKSMSALTAEALEAYLKERRRRALGLKVLERAGKGRVAGEAHRLLEEGRRDRP
>NC_005838.1|WP_011174362.1|204563_204977_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MIPERLVLDAGPLIALLHRSDPDHEEAVRGFRRLAEGGARLFLPMPVLFEVFKWLLFQAGPKAAREGLAKVEEGAVVVPFTLEDLEEVRLLLARLPGWGGTLEDAGVALLALRLGAPVWTLNYRDLGAFPALRFWTP
>NC_005838.1|WP_011174361.1|204973_205204_-|ribbon-helix-helix-protein,-CopG-family
MMMCDMRVTIYLPDHLAQEVEAYRKARPGLSLSALVRELLERELVKRPEALLEVAGLVEKAELSAREHDALIREER
>NC_005838.1|WP_011174360.1|205467_206433_+|recombinase-XerD
MREGLGLEVWDHPEERRRVVGEALARWDEALLKEALWAYLVRHRKKPDRVAPHYVGYFVRWLALKGRRWPHLEPEDPKAFLLEAKEKGFPGGERGPMAWSTVERARASLRHLFPFLDWAGHPMPSHVRLPSRQELPVVAPSRAMPEEAYRDLLEKAGAYPLAYWRPLLRVLLVLLGEVGLTVKEAVELWQEDVREKVLLVRGTKLREVPLSPLAREVLADWLPQRAFLASHQPLPYPHLLLKPAPGKNRGKPLGLEEAKWILTEFADFAGVKAEGKKRADLALPLRWRAIRRFLKEGHPREKVAYWTGMKSLVVPGWGEEG
>NC_005838.1|WP_014511095.1|206966_207116_+|hypothetical-protein
MPRKTRPKTQEEAPFLITPPRKKGKPPLPEPVAPKPGKPSLAYLQEQRR
>NC_005838.1|WP_011174359.1|207112_207583_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MRLFLETSGLLKVLLREDLSDLAREAFSQAQAHAASAFALPEAVGVLHAMQRDGRLTRPLYRKALRELYELWEYLEVLTPTLEGHMRAARLCERHPLKGADAVHLEGALFLKGLYPDTALLTFDRTLYRAAKKEGLTVVRVPPLEGLTPRPHKKSS
>NC_005838.1|WP_011174358.1|207698_209327_-|IS1634-like-element-ISTth3-family-transposase
METTPNLQVYDLGHLGLVASIVDQIGLVQTVDQFVGPRPGEKVSTGMALKAAILNALGFVTSPLYLFGHFFQGKPTELLLGPGITPELLNDDRMGRMLDSLYAAGVTELFVEVAKSARRAFPFPVRALHVDSTSFHVHGAYGSGEEGQSDTGDEPLVIRLTHGYSRDHRPDLKQWVMNLICADTGGIPLLFAPGDGNQSDQEALVPLLARYRQGLELGEVVVLDGASYSQENLGALQGFSWVMRVPATLKEARALLRKELPQEAWRPLLPGYRGLEVESEYGGVRQRWLLVESQERARMEEASLRQRIVRAEGEARKVLGQLTARTFACEADARRALSEASGRLPLHRLVYLGVQEERQWERVGRPGKGERPLAVVYRLRARLEVDQEKLERARRGLGRFLLATNVLDREGLPPQEVLRRYKDQARTVERGFRFLKDPLFFAESTFLKRPERVMALGMVMALALLVYALGEWALRRRLWEAGSSLPDQKGRPTAKPTLRWVFQLFMWVRLVELGGRWFVLNLAPHHETAARLLGAGRYYLLE
>NC_005838.1|WP_041443967.1|209336_209534_-|hypothetical-protein
MGYQSRATLVQVQGIAGVREAAGGWDFTVIFKEDGTVWSVGANNYGQLGDGTHLDPTFRTPLPWP
>NC_005838.1|WP_011174357.1|209852_211073_-|ATP-binding-protein
MERTFLPRAAGPLLERLLEVFPVVAVMGARQVGKSTLVRHLPALKGYLYLSLDDLDLRLQAEADPRVLLERGDRLILDEVQRVPELLLAIKRSVDEARIPGRFVLTGSAHLLLHAHLGETLAGRAAHLVLWPMTRREQRGLGRAGLWGELLALPLEAWPSFLREARDLREDWRSAVARGGFPVPALLLKDWEERQMWLRAYLQTYLERDVPALRAVENLPELRKLMEALALRSGSLLNQSELARDLGISQPTVHRYLNLLEVSFLLVRLRGYARSRTKRLVKSPKVYLPDPALALYLAGGSPSGAHLETLVLLDLLAFRDAQKNPPGLYYWRTASGQEVDFVLEVGEKLLPVEVKATSRPTPKDAQGLLAFLAEYPEVPGGLLLHGGEEVFPLVDRVVAAPWWAVA
>NC_005838.1|WP_011173580.1|211679_212633_+|IS110-family-transposase
MTFAGIDVSKPHLDLALVSNSPKPTRLRFPNTPEGRKALLAALAHLRPAWVALEPTGAYHLPLLKLLAENRLQVALVNPYHLAAFRKAKGERQKTDRHDALLLARYAQVYHGELRAYTLPPEALRELKALVGYREDLAGRERAILNQMEAVEWAGSGEVLALLQKELACVKGLLGEVEARIQALLATLPEAEALMALPGVGPQVAAAVLALLPPELWGRAKRAASYAGLTPEREESGKRVERSRLSKKGPPLLRRKLYMGALVAVRHDPEMRAFYHRLLSRGKRKKQALVAVAHKLLRRMMGRLREYYATQLDQGVA
>NC_005838.1|WP_162467440.1|213421_213661_+|hypothetical-protein
MRKMKLGICTRRITGVFEGLHRWKATGERGDEKKKRIFAFRKGKNGFQDPHPEVRVGKSIAHTATLHQVKISAKKRLPK

Crispr_ID: NC_005838_9

• CRISPR_ID: NC_005838_9
• CRISPR_location: 212645-213370
• CRISPR_type: Unclear
• Repeat_type: III-A
• Spacer_info: 9 spacers
• Cas_protein_info: cas6

Consensus repeat of NC_005838_9

Consensus_repeat	Method
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CRISPRCasFinder
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CRT
GTTGCAAGGGATTGAGCCCCGTAAGGGGATTGCGAC	PILER-CR

spacers of NC_005838_9

>9.1|212681|39|NC_005838|CRISPRCasFinder,CRT
TCAGGAAACTAAGGCCCAGGACAAACCCGTTGCCTACAA
>9.2|212756|41|NC_005838|CRISPRCasFinder,CRT,PILER-CR
AAGGCAGGGGAGTTCGGCAAGAAGCTTGAGCAGTACTTCAA
>9.3|212833|41|NC_005838|CRISPRCasFinder,CRT,PILER-CR
AGAAGCCCTCTACACGGGCGAAGAAGCCCTCTACACGTACG
>9.4|212910|45|NC_005838|CRISPRCasFinder,CRT,PILER-CR
ATTTGAAAGAGGCGAAACCAGGGCCCTCCTCCCTGGGTCGCAATC
>9.5|212991|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR
CCCTAGTGGAGGTGAGCCTTGAGGCGTAAGCTGAAGT
>9.6|213064|42|NC_005838|CRISPRCasFinder,CRT,PILER-CR
CGAGGGCGATCCTCGCACTCAGGCCAGAAGGCAGTCCAGAAA
>9.7|213142|40|NC_005838|CRISPRCasFinder,CRT,PILER-CR
GTAAGGTGTTAAGAAGCGTGTTTTTCGGACTTGGGGCGGC
>9.8|213218|41|NC_005838|CRISPRCasFinder,CRT,PILER-CR
GGAGGCCTTGTCGGACCCCGAGGCCGCCCCTCTCGCCCGGG
>9.9|213295|40|NC_005838|CRISPRCasFinder,CRT,PILER-CR
TAAGCCCCAAGGAAGGGAGTTTGCGTGGATCCTGAAAGAG

CRISPR arrays and Neighbor proteins around NC_005838_9

CRISPR arrays

The CRISPR arrays of NC_005838_9

>merge|NC_005838|9|212645-213370|CRISPRCasFinder,CRT,PILER-CR
GTATCAATCCCCTTACGGGGCTCAATCCCTTGCAACTCAGGAAACTAAGGCCCAGGACAAACCCGTTGCCTACAAGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACAAGGCAGGGGAGTTCGGCAAGAAGCTTGAGCAGTACTTCAAGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACAGAAGCCCTCTACACGGGCGAAGAAGCCCTCTACACGTACGGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACATTTGAAAGAGGCGAAACCAGGGCCCTCCTCCCTGGGTCGCAATCGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACCCCTAGTGGAGGTGAGCCTTGAGGCGTAAGCTGAAGTGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACCGAGGGCGATCCTCGCACTCAGGCCAGAAGGCAGTCCAGAAAGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACGTAAGGTGTTAAGAAGCGTGTTTTTCGGACTTGGGGCGGCGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACGGAGGCCTTGTCGGACCCCGAGGCCGCCCCTCTCGCCCGGGGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAACTAAGCCCCAAGGAAGGGAGTTTGCGTGGATCCTGAAAGAGGTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC

>NC_005838|9|8|212645-213370|CRISPRCasFinder
GTATCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TCAGGAAACTAAGGCCCAGGACAAACCCGTTGCCTACAA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	AAGGCAGGGGAGTTCGGCAAGAAGCTTGAGCAGTACTTCAA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	AGAAGCCCTCTACACGGGCGAAGAAGCCCTCTACACGTACG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	ATTTGAAAGAGGCGAAACCAGGGCCCTCCTCCCTGGGTCGCAATC
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CCCTAGTGGAGGTGAGCCTTGAGGCGTAAGCTGAAGT
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CGAGGGCGATCCTCGCACTCAGGCCAGAAGGCAGTCCAGAAA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	GTAAGGTGTTAAGAAGCGTGTTTTTCGGACTTGGGGCGGC
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	GGAGGCCTTGTCGGACCCCGAGGCCGCCCCTCTCGCCCGGG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TAAGCCCCAAGGAAGGGAGTTTGCGTGGATCCTGAAAGAG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC

>NC_005838|9|8|212645-213370|CRT
GTATCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TCAGGAAACTAAGGCCCAGGACAAACCCGTTGCCTACAA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	AAGGCAGGGGAGTTCGGCAAGAAGCTTGAGCAGTACTTCAA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	AGAAGCCCTCTACACGGGCGAAGAAGCCCTCTACACGTACG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	ATTTGAAAGAGGCGAAACCAGGGCCCTCCTCCCTGGGTCGCAATC
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CCCTAGTGGAGGTGAGCCTTGAGGCGTAAGCTGAAGT
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CGAGGGCGATCCTCGCACTCAGGCCAGAAGGCAGTCCAGAAA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	GTAAGGTGTTAAGAAGCGTGTTTTTCGGACTTGGGGCGGC
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	GGAGGCCTTGTCGGACCCCGAGGCCGCCCCTCTCGCCCGGG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TAAGCCCCAAGGAAGGGAGTTTGCGTGGATCCTGAAAGAG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC

>NC_005838|9|9|212720-213370|PILER-CR
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	AAGGCAGGGGAGTTCGGCAAGAAGCTTGAGCAGTACTTCAA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	AGAAGCCCTCTACACGGGCGAAGAAGCCCTCTACACGTACG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	ATTTGAAAGAGGCGAAACCAGGGCCCTCCTCCCTGGGTCGCAATC
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CCCTAGTGGAGGTGAGCCTTGAGGCGTAAGCTGAAGT
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	CGAGGGCGATCCTCGCACTCAGGCCAGAAGGCAGTCCAGAAA
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	GTAAGGTGTTAAGAAGCGTGTTTTTCGGACTTGGGGCGGC
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	GGAGGCCTTGTCGGACCCCGAGGCCGCCCCTCTCGCCCGGG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC	TAAGCCCCAAGGAAGGGAGTTTGCGTGGATCCTGAAAGAG
GTCGCAATCCCCTTACGGGGCTCAATCCCTTGCAAC

Neighbor Proteins Overview

Protein	Signature genes	Signature genes Name	Protein_function
NC_005838.1|WP_011174358.1|207698_209327_-|IS1634-like-element-ISTth3-family-transposase	unknown	unknown	gnl|CDD|227708
NC_005838.1|WP_014511095.1|206966_207116_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174347.1|221616_223665_+|beta-galactosidase	unknown	unknown	gnl|CDD|225789
NC_005838.1|WP_011174360.1|205467_206433_+|recombinase-XerD	unknown	unknown	gnl|CDD|227308
NC_005838.1|WP_041443975.1|225273_227889_-|transcriptional-regulator	unknown	unknown	gnl|CDD|226456
NC_005838.1|WP_011174361.1|204973_205204_-|ribbon-helix-helix-protein,-CopG-family	unknown	unknown	unknown
NC_005838.1|WP_011173580.1|211679_212633_+|IS110-family-transposase	unknown	unknown	gnl|CDD|376564
NC_005838.1|WP_011174349.1|217502_219227_+|beta-galactosidase	unknown	unknown	gnl|CDD|236657
NC_005838.1|WP_011174357.1|209852_211073_-|ATP-binding-protein	unknown	unknown	gnl|CDD|224292
NC_005838.1|WP_148187589.1|214809_215331_+|lamin-tail-domain-containing-protein	unknown	unknown	gnl|CDD|376421
NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	gnl|CDD|273848
NC_005838.1|WP_050724186.1|219289_221620_+|glycoside-hydrolase-family-31-protein	unknown	unknown	gnl|CDD|224418
NC_005838.1|WP_041443967.1|209336_209534_-|hypothetical-protein	unknown	unknown	gnl|CDD|379248
NC_005838.1|WP_162467440.1|213421_213661_+|hypothetical-protein	unknown	unknown	unknown
NC_005838.1|WP_011174351.1|215438_216233_+|carbohydrate-deacetylase	unknown	unknown	gnl|CDD|212113
NC_005838.1|WP_011174362.1|204563_204977_-|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|224761
NC_005838.1|WP_011174359.1|207112_207583_+|type-II-toxin-antitoxin-system-VapC-family-toxin	unknown	unknown	gnl|CDD|350222
NC_005838.1|WP_011174346.1|223664_224927_+|MFS-transporter	unknown	unknown	gnl|CDD|340890
NC_005838.1|WP_011174350.1|216246_217500_+|MFS-transporter	unknown	unknown	gnl|CDD|340890
NC_005838.1|WP_050724185.1|214290_214791_+|M23-family-metallopeptidase	unknown	unknown	gnl|CDD|366703

HMMScan for Signature genes

Protein	Cas_name	Cas_description	E-value	Identity	Coverage
NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6	cas6	cd09652_cas6_CAS-I:CAS-III	1.3e-35	118.3	0.0

rpsblast for functional proteins

Protein	Function_ID	Function_description	E-value
NC_005838.1|WP_011174358.1|207698_209327_-|IS1634-like-element-ISTth3-family-transposase	gnl|CDD|227708	COG5421, COG5421, Transposase [DNA replication, recombination, and repair].	2.69938e-55
NC_005838.1|WP_011174360.1|205467_206433_+|recombinase-XerD	gnl|CDD|227308	COG4974, XerD, Site-specific recombinase XerD [DNA replication, recombination, and repair].	6.9815e-08
NC_005838.1|WP_011174347.1|221616_223665_+|beta-galactosidase	gnl|CDD|225789	COG3250, LacZ, Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism].	8.56791e-27
NC_005838.1|WP_041443975.1|225273_227889_-|transcriptional-regulator	gnl|CDD|226456	COG3947, COG3947, Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms].	5.73494e-11
NC_005838.1|WP_011173580.1|211679_212633_+|IS110-family-transposase	gnl|CDD|376564	pfam01548, DEDD_Tnp_IS110, Transposase. Transposase proteins are necessary for efficient DNA transposition. This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and of members of the IS111A/IS1328/IS1533 family of transposases. The C-terminus is represented by family pfam02371.	2.18932e-28
NC_005838.1|WP_011174349.1|217502_219227_+|beta-galactosidase	gnl|CDD|236657	PRK10150, PRK10150, beta-D-glucuronidase; Provisional.	1.1263e-34
NC_005838.1|WP_011174351.1|215438_216233_+|carbohydrate-deacetylase	gnl|CDD|212113	cd10802, YdjC_TTHB029_like, Thermus thermophiles TTHB029 and similar proteins. This subfamily is represented by an YdjC-family protein TTHB029 from Thermus thermophilus HB8; it is similar to Escherichia coli YdjC, a hypothetical protein encoded by the celG gene. TTHB029 functions as a homodimer. Each of monomer consists of (beta/alpha)-barrel fold. The molecular function of TTHB029 is unclear.	4.16283e-74
NC_005838.1|WP_148187589.1|214809_215331_+|lamin-tail-domain-containing-protein	gnl|CDD|376421	pfam00932, LTD, Lamin Tail Domain. The lamin-tail domain (LTD), which has an immunoglobulin (Ig) fold, is found in Nuclear Lamins, Chlo1887 from Chloroflexus, and several bacterial proteins where it occurs with membrane associated hydrolases of the metallo-beta-lactamase,synaptojanin, and calcineurin-like phosphoesterase superfamilies.	5.26201e-15
NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6	gnl|CDD|273848	TIGR01877, CRISPR-associated_endoribonuclease_Cas6_1, CRISPR-associated endoribonuclease Cas6. CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.	3.73308e-33
NC_005838.1|WP_050724186.1|219289_221620_+|glycoside-hydrolase-family-31-protein	gnl|CDD|224418	COG1501, COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism].	0
NC_005838.1|WP_041443967.1|209336_209534_-|hypothetical-protein	gnl|CDD|379248	pfam13540, RCC1_2, Regulator of chromosome condensation (RCC1) repeat.	2.4553e-05
NC_005838.1|WP_011174357.1|209852_211073_-|ATP-binding-protein	gnl|CDD|224292	COG1373, COG1373, Predicted ATPase (AAA+ superfamily) [General function prediction only].	1.23209e-59
NC_005838.1|WP_011174362.1|204563_204977_-|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|224761	COG1848, COG1848, Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only].	3.54521e-07
NC_005838.1|WP_011174359.1|207112_207583_+|type-II-toxin-antitoxin-system-VapC-family-toxin	gnl|CDD|350222	cd09874, PIN_MT3492-like, VapC-like PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins. Virulence associated protein C (VapC)-like PIN (PilT N terminus) domain of Mycobacterium tuberculosis CDC1551, hypothetical protein MT3492, and similar bacterial and archaeal proteins are included in this subfamily. They are PIN domain homologs of the Mycobacterium tuberculosis VapC and Neisseria gonorrhoeae FitB toxins of the prokaryotic toxin/antitoxin operons, VapBC and FitAB, respectively, which are believed to be involved in growth inhibition by regulating translation. These toxins are nearly always co-expressed with an antitoxin, a cognate protein inhibitor, forming an inert protein complex. Disassociation of the protein complex activates the ribonuclease activity of the toxin by an, as yet undefined mechanism. The PIN domain belongs to a large nuclease superfamily. The structural properties of the PIN (PilT N terminus) domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions, in some members, additional metal coordinating residues can be found. Some members of the superfamily lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons.	3.88829e-26
NC_005838.1|WP_011174346.1|223664_224927_+|MFS-transporter	gnl|CDD|340890	cd17332, MFS_MelB_like, Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily. This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	3.45279e-88
NC_005838.1|WP_011174350.1|216246_217500_+|MFS-transporter	gnl|CDD|340890	cd17332, MFS_MelB_like, Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily. This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.	7.02369e-71
NC_005838.1|WP_050724185.1|214290_214791_+|M23-family-metallopeptidase	gnl|CDD|366703	pfam01551, Peptidase_M23, Peptidase family M23. Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins. LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	1.54434e-32

Protein sequences

>NC_005838.1|WP_011173580.1|211679_212633_+|IS110-family-transposase
MTFAGIDVSKPHLDLALVSNSPKPTRLRFPNTPEGRKALLAALAHLRPAWVALEPTGAYHLPLLKLLAENRLQVALVNPYHLAAFRKAKGERQKTDRHDALLLARYAQVYHGELRAYTLPPEALRELKALVGYREDLAGRERAILNQMEAVEWAGSGEVLALLQKELACVKGLLGEVEARIQALLATLPEAEALMALPGVGPQVAAAVLALLPPELWGRAKRAASYAGLTPEREESGKRVERSRLSKKGPPLLRRKLYMGALVAVRHDPEMRAFYHRLLSRGKRKKQALVAVAHKLLRRMMGRLREYYATQLDQGVA
>NC_005838.1|WP_011174357.1|209852_211073_-|ATP-binding-protein
MERTFLPRAAGPLLERLLEVFPVVAVMGARQVGKSTLVRHLPALKGYLYLSLDDLDLRLQAEADPRVLLERGDRLILDEVQRVPELLLAIKRSVDEARIPGRFVLTGSAHLLLHAHLGETLAGRAAHLVLWPMTRREQRGLGRAGLWGELLALPLEAWPSFLREARDLREDWRSAVARGGFPVPALLLKDWEERQMWLRAYLQTYLERDVPALRAVENLPELRKLMEALALRSGSLLNQSELARDLGISQPTVHRYLNLLEVSFLLVRLRGYARSRTKRLVKSPKVYLPDPALALYLAGGSPSGAHLETLVLLDLLAFRDAQKNPPGLYYWRTASGQEVDFVLEVGEKLLPVEVKATSRPTPKDAQGLLAFLAEYPEVPGGLLLHGGEEVFPLVDRVVAAPWWAVA
>NC_005838.1|WP_041443967.1|209336_209534_-|hypothetical-protein
MGYQSRATLVQVQGIAGVREAAGGWDFTVIFKEDGTVWSVGANNYGQLGDGTHLDPTFRTPLPWP
>NC_005838.1|WP_011174358.1|207698_209327_-|IS1634-like-element-ISTth3-family-transposase
METTPNLQVYDLGHLGLVASIVDQIGLVQTVDQFVGPRPGEKVSTGMALKAAILNALGFVTSPLYLFGHFFQGKPTELLLGPGITPELLNDDRMGRMLDSLYAAGVTELFVEVAKSARRAFPFPVRALHVDSTSFHVHGAYGSGEEGQSDTGDEPLVIRLTHGYSRDHRPDLKQWVMNLICADTGGIPLLFAPGDGNQSDQEALVPLLARYRQGLELGEVVVLDGASYSQENLGALQGFSWVMRVPATLKEARALLRKELPQEAWRPLLPGYRGLEVESEYGGVRQRWLLVESQERARMEEASLRQRIVRAEGEARKVLGQLTARTFACEADARRALSEASGRLPLHRLVYLGVQEERQWERVGRPGKGERPLAVVYRLRARLEVDQEKLERARRGLGRFLLATNVLDREGLPPQEVLRRYKDQARTVERGFRFLKDPLFFAESTFLKRPERVMALGMVMALALLVYALGEWALRRRLWEAGSSLPDQKGRPTAKPTLRWVFQLFMWVRLVELGGRWFVLNLAPHHETAARLLGAGRYYLLE
>NC_005838.1|WP_011174359.1|207112_207583_+|type-II-toxin-antitoxin-system-VapC-family-toxin
MRLFLETSGLLKVLLREDLSDLAREAFSQAQAHAASAFALPEAVGVLHAMQRDGRLTRPLYRKALRELYELWEYLEVLTPTLEGHMRAARLCERHPLKGADAVHLEGALFLKGLYPDTALLTFDRTLYRAAKKEGLTVVRVPPLEGLTPRPHKKSS
>NC_005838.1|WP_014511095.1|206966_207116_+|hypothetical-protein
MPRKTRPKTQEEAPFLITPPRKKGKPPLPEPVAPKPGKPSLAYLQEQRR
>NC_005838.1|WP_011174360.1|205467_206433_+|recombinase-XerD
MREGLGLEVWDHPEERRRVVGEALARWDEALLKEALWAYLVRHRKKPDRVAPHYVGYFVRWLALKGRRWPHLEPEDPKAFLLEAKEKGFPGGERGPMAWSTVERARASLRHLFPFLDWAGHPMPSHVRLPSRQELPVVAPSRAMPEEAYRDLLEKAGAYPLAYWRPLLRVLLVLLGEVGLTVKEAVELWQEDVREKVLLVRGTKLREVPLSPLAREVLADWLPQRAFLASHQPLPYPHLLLKPAPGKNRGKPLGLEEAKWILTEFADFAGVKAEGKKRADLALPLRWRAIRRFLKEGHPREKVAYWTGMKSLVVPGWGEEG
>NC_005838.1|WP_011174361.1|204973_205204_-|ribbon-helix-helix-protein,-CopG-family
MMMCDMRVTIYLPDHLAQEVEAYRKARPGLSLSALVRELLERELVKRPEALLEVAGLVEKAELSAREHDALIREER
>NC_005838.1|WP_011174362.1|204563_204977_-|type-II-toxin-antitoxin-system-VapC-family-toxin
MIPERLVLDAGPLIALLHRSDPDHEEAVRGFRRLAEGGARLFLPMPVLFEVFKWLLFQAGPKAAREGLAKVEEGAVVVPFTLEDLEEVRLLLARLPGWGGTLEDAGVALLALRLGAPVWTLNYRDLGAFPALRFWTP
>NC_005838.1|WP_011174364.1|202188_202983_+|CRISPR-associated-endoribonuclease-Cas6
MPQAVVLELVGEKPPLYPARYAHGLFFALLSRVSPELAQKLHEAPRKPFTLAPLPRAGPEGATLKGTLRLRLTTLDDGLFAPFLRALLEAAPDGLPLGDSSYRLARVLATREGHPLAGATSWEELKEAPKREKVTFRFLTPTVFATSKPGGRTRYTPLPDPRLIAGSLLDKWQAHSPFPYNPKEEAALRGLFELDLEVAGFRNLRFHRVQAGKGFFPGFTGEMTLRLWSQSLEAREALGRLHALAFFSGVGAKTPYGMGLAVPL
>NC_005838.1|WP_162467440.1|213421_213661_+|hypothetical-protein
MRKMKLGICTRRITGVFEGLHRWKATGERGDEKKKRIFAFRKGKNGFQDPHPEVRVGKSIAHTATLHQVKISAKKRLPK
>NC_005838.1|WP_050724185.1|214290_214791_+|M23-family-metallopeptidase
MLASPFQGEFRVTNVSDHEYPFQFQDNNGYLFSWWGEKLPGVDGHQGYDFPMPEGTPLLAAYDGEVTFAGWENPFYCPPLDKTVSGLGVVLRHRLPNGEVFLSIYAHMSEVHVKTGNLVRTGQVLGLSGNTGCSTGPHLHFEMRRLRGTAWPVFDPYGWEGEGEDP
>NC_005838.1|WP_148187589.1|214809_215331_+|lamin-tail-domain-containing-protein
MSSVWLWAEGKAPSLFSEVNLPPNPQPTDRAPVAITRVRYMGVNDALNPNNEFVEITVDPRFASAPVALRGFLLQNKLGETFAFPDLTLEPGASLRVYTGQGNPTREALFWNRTQPAWDNWGDCVQLVYPSGGRYRVGYRSGCAVTQGFKVLVEEKEDALLDAHRLPPPVATP
>NC_005838.1|WP_011174351.1|215438_216233_+|carbohydrate-deacetylase
MDLLERLGLGGRRVLILHHDDLGLTHAQNGAYQALGLPTGSVMVPGAWASGVKGEDLGVHLVLTSEWPAPRMRPLTEGESLRDEAGYFPEGLEALWRKARAEEVERELKAQIQAAAKLFSPTHLDTHQGAVLRPDLAEVYLRLAEAYRLVPLVPESLEGLGVPPPFLPELERLLYETPFPRVRFLDPYGLPPEERLGFYLDLAHLPPGLYYLVHHSALPTPEGRALPDWPTREADYFALSHPEVRRVLAEFHPLTWRAVREALF
>NC_005838.1|WP_011174350.1|216246_217500_+|MFS-transporter
MKKRRYASGQLGLTLVSESFGTYLAFFYLERLGLSAALYALARTVYALWDAVNDPLFGHLSDRTKTPWGRRRPWLLLGVPLFLLAYLLVFWVPDWARSPAVLPYYFALAILLYETLATVVWTNHGALFPEMFRGLRERAEAAALKRGAELLGLILGIALAPMVYARVGFFGMALLFAGLALLAFLYFFPGIREDPRAGSGLGLWASFRLVLANRAFWVVALVGLLFEFGRMALQTAIPFYAKHALGLEEGATTFLFAAVFLAALPSALLWGRLAGAWGGKRAWRLAHLLMGLSALLLFLPQGLPAALLAGALVGAGFAGVRVTGEVVMAKVIDLDVERTETRREGAYYSLVGLLGRAAGALVGLAFALLTPLFGYVSGENPGPNPEAAFRFLVAVVPGTAILLAYALTALFPHEVKE
>NC_005838.1|WP_011174349.1|217502_219227_+|beta-galactosidase
MRLDPNHPRPTLQRPGWRSLEGHWDFALSEAEAPGGVRFDRKILVPFPPEAPGSGVGEAWVGVAWYRKVLRAKPRPGRRLFLRFGAVDYRAEVFVNGVRVLEHEGGHTPFGLDLTPFLERPVEVLVRAEDDPLDPEAPRGKQALGEPGGIFYPRTTGIWQPVWLEWVPESHIAALRLTPDLKALGFHLEVQAHGEGEAVEVALFPGVRGEAPLGEAPWLEARFPLLGERASGFLGLPAKGSPEGLLWRPETPVLFPLRLRLLSGRRVLDEVYSYGGLREVAAQKGVFLLNGEPYFPRLVLDQGLWPEGHLAPPSLAALRRDAALAKALGFNGVRKHQKVEDPRYLHLADRLGLLVFAEMPSFFRFSPKAARRYLAELAEALERDRNHPSLVAWILFNEGWGLTPWRAETLAFLQGAFLLARALDPTRLLVDNDGFEHGPFWDLLTVHDYAPPEVLARRYGEGLPEAPMGRPLALAGLPPGVRPFLSEFGGLRLKGPGPGWGYREAEGEEAFLREALRYLETACGSRLSGFCYTQLYDTFQEENGLLDFWRRPKVPPERVRAFLEGCEARRLLAE
>NC_005838.1|WP_050724186.1|219289_221620_+|glycoside-hydrolase-family-31-protein
MAALLGPGILLLAVRYARERDRWTPRDPLPPWQGVGRVQGLEAIPGGVRVRFAEAELEAVFLGEDLLRLTWSPGEALPPYALAEEASPLEPERLRGPDGVLLLRTRRLALALGEEGLEVRDGEGRLLRQEAYPERAGRAWRHRVRLAPGERVLGLGERAYPLDRRGGAFRLWNRDPGGSYGPGEDPLYLSVPVWLSLLPQGGYLAFYENPAEGFADLRGEEAWVGFLGGAFRYYLIPGPLEAALSRYVRLTGLPPMPPRWALGFHYARWGLRTREEVEERVAGFLERGLPLRAVHLDIDYMRGYRVFTVDEGRYPDLPGLVRGFQEKGVRTVLILDPGVKAEKGFPPYEEGLREGLFCRLPSGEVVRGPVWPGLAAFPDFTDPKARAWWGEKLKGFLEMGVAGLWLDMNEPALFAAWGEPTLPASARHALEGQGGDHRLAHNLYGLLMARASWEGFRKHAPERRPFLLTRSGHAGVQRYAWAWTGDVESTWEGLRTTLRALLGLSLSGVYFVGSDIGGFSGNPSPELYLRWFQMAALTPFFRLHAARWTKRREPWRFGEEVLEGVRRAMALRESLLPYLYTLAHRASREGKPLLRPLFLEGGPYTEEAFLLGEALLVAPVLEEGARAKEVPLPKGGWYPWGEDRALQGPTWARLPAPLDRIPLLVRAGTVLPLLEEGGLALHLYPGAEGAEGRLYWDEGEGEGPYRLDRFRLLPAEGGFRLLWQGKGELPWPWARVRLRLFGKRLLRAHVEGEAHAAEEGGVLLPPFREALLEVEG
>NC_005838.1|WP_011174347.1|221616_223665_+|beta-galactosidase
MRVEKAWFLADGAEAPEGLPEGGFREVALPHQWSLEGVEAEVGWYRLALPEAGPRRFLLSFGDYYQEAWLDGTYLGRHEGYFFPWVLELPKGKELFLRVSAPKEPLGVWPRFKRQIKGVFGQHDCRPGGTTARGQERGTGGLWGGVEVWAREEVALLGLTHRLFPRPGGWRLWARLLVDATRPFRERARLALSPVNFPGEVLEREALLEGEAGRGWREVVWDLPEMPLWEVWERGFPHLFRLEADLLGARLGVPLGFRTVAVDGEGWLLLNGKRLFLRGTNAIPTQWLAGYSEEMAQRDVALIKEAGLNAVRVHAHVTHPAFYEGCDREGVLVWQDFPLQWGYAPDEAFAQEALRQARAMVEVLGAHPSAYLWCAQNEPTHNRHALGPLLGAALRAADPTRPVKEASDFREHPYPGWYWGHYRDFLALPGAPLPSEFGAQALPRAELLRRVLGEAAWPPRWEVWGYHNFQPHETFRVAGVEMGESLEEFVERSQDYQARLLEFAVHAYRRAKGKVVGYFQFMFVEPWEGITWAVLDVERVPKKGFFALKEASSPVLLSLVPYLERVEVGAPPLQEAWLVSDLDRPLSLRVRLRLEGPATLLLHEEEIALDAGEVRRFFSLGELWESPLEVQARFLPLREALARIPPGAYRLVGEAWEGERLWSRHVLSVEYLEPILPLEVAW
>NC_005838.1|WP_011174346.1|223664_224927_+|MFS-transporter
MPPHLAYALGGLGLTLPAQTFGTYLAFYYLDRLGMPTGAFALARLIFSVWDAVNDPLFGYLSDRTRTPWGRRRPWLFLSLPFLLLAFYLAFSVPEAFREGTRLFWYGLWAMLLFETFSALAWVNHAALFPELFQSREERARANAWRQGFYFLGLTASIALTPLVYAALGFPGMALLYGAVGGGLVLLFLLSVREDPRAREAEPLPFVPAFRYTLGNRAFWIYALAALFLLFAVGLFAAAMPFYAKYALGLGEEATALLFASVLLAALPSVSLWARLAGALGPKRAWLWAIGLLALGALLLLWPRGLLEALPVGVLIGTGFGGVLVLGDVLLAEVIDRDAAATGRRREGVYYSVYGFVNRLSGPLQALAFALLTPLFGYVSGENPGPNPEAAFRFLMAVPPFAASLLALALAARFPYGAKG
>NC_005838.1|WP_041443975.1|225273_227889_-|transcriptional-regulator
MALAWQSPVYLERKRLLDLLPEEPGFAVWLEAPAGFGKSVLAGQLAARLGLRTLWASALLGEPRDLLAQALGLPREAPWGAVVAALGEAPSLVVLEDLTGEEALSPLLRTLPCLLVLASRRPLPYPELPKLLAEGRLVHLKAPDLAFTEEEAEALFGGREGWREAHRATGGWALPLFLSAFTGRPPEPMALLQGLRESLSEEEFQEGLLLAALPLLPAERALPVTEGLFQKGLLQRVPAGYRLHPLLREMAQRALRAEVQEAVRKAEGRLPPELLAEALFGAGLEEELLQLLESPIPLPIPAEKLAAWEGLLRRGGPRARLRLGEALLQVGRREGFALLEPLAQGEDPALALQALGHLAYYKAEPLLGKALPEARAHLERGLALLDRVGGELAGRFLNDAARVPYEEGRPEEAEALLEEALRRLPPESPYRLAPLTNLAFLRFEREGSLLGRIAALEEAVGRLGPLGPANLAGHLRDLGRLYLLLGEREKAREHLRRAQEAEGHPLAALEARMLLAHLEEDAEALARLVAQAELLENPYLVERGRALLAGLRRDPGLLEGLPGFLPALARALLREDPALLPPRPEAREERLYWHAARYRLLREEEDLKALLSLTDARERVLPGLVPLDLLPRKRPELARAYPLEEVLRSGWKEAVALRLAEIPPLRVEVLGSFRVRNPLGGVELKGKAREVLAILLLGLPREEVAFALWPDLSEEAALNNLYVWLNRLRKALEPWGLPTYLGEEGLKHLACDLHALEEALRREDAEAAFALYREPLFPGLDHPLLDRKREEVFHRVRALFLKKGEPRYLERLLELDPLDEEALLPLVERCLARGQRARALAHLERYRRRLWEELGERPSPEVEALLRELGG

MGE targeting detection<

CRISPR_ID	Spacer_Info	Spacer_region	Spacer_length	Hit_phage_ID	Hit_phage_def	Protospacer_location	Mismatch	Identity
NC_005838_1	1.1|2391|60|NC_005838|PILER-CR	2391-2450	60	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	38275-38334	0	1.0
NC_005838_1	1.1|2391|60|NC_005838|PILER-CR	2391-2450	60	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	2381-2440	0	1.0
NC_005838_1	1.2|2490|60|NC_005838|PILER-CR	2490-2549	60	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	38671-38730	0	1.0
NC_005838_1	1.2|2490|60|NC_005838|PILER-CR	2490-2549	60	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	2480-2539	0	1.0
NC_005838_1	1.2|2490|60|NC_005838|PILER-CR	2490-2549	60	NZ_LR027520	Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence	243745-243804	0	1.0
NC_005838_2	2.1|92194|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT	92194-92231	38	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	92194-92231	0	1.0
NC_005838_2	2.2|92268|41|NC_005838|PILER-CR,CRISPRCasFinder,CRT	92268-92308	41	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	92268-92308	0	1.0
NC_005838_2	2.3|92345|44|NC_005838|PILER-CR,CRISPRCasFinder,CRT	92345-92388	44	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	92345-92388	0	1.0
NC_005838_3	3.1|100491|40|NC_005838|PILER-CR	100491-100530	40	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	100491-100530	0	1.0
NC_005838_3	3.2|100568|36|NC_005838|PILER-CR	100568-100603	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	100568-100603	0	1.0
NC_005838_3	3.3|100641|37|NC_005838|PILER-CR	100641-100677	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	100641-100677	0	1.0
NC_005838_3	3.4|100490|41|NC_005838|CRISPRCasFinder,CRT	100490-100530	41	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	100490-100530	0	1.0
NC_005838_3	3.5|100567|37|NC_005838|CRISPRCasFinder,CRT	100567-100603	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	100567-100603	0	1.0
NC_005838_3	3.6|100640|38|NC_005838|CRISPRCasFinder,CRT	100640-100677	38	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	100640-100677	0	1.0
NC_005838_3	3.7|100714|42|NC_005838|CRISPRCasFinder,CRT	100714-100755	42	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146078-146119	0	1.0
NC_005838_3	3.7|100714|42|NC_005838|CRISPRCasFinder,CRT	100714-100755	42	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	100714-100755	0	1.0
NC_005838_3	3.8|100792|44|NC_005838|CRISPRCasFinder,CRT	100792-100835	44	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146156-146199	0	1.0
NC_005838_3	3.8|100792|44|NC_005838|CRISPRCasFinder,CRT	100792-100835	44	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	100792-100835	0	1.0
NC_005838_3	3.9|100872|41|NC_005838|CRISPRCasFinder,CRT	100872-100912	41	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	100872-100912	0	1.0
NC_005838_3	3.10|100949|40|NC_005838|CRISPRCasFinder,CRT	100949-100988	40	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146236-146275	0	1.0
NC_005838_3	3.10|100949|40|NC_005838|CRISPRCasFinder,CRT	100949-100988	40	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	100949-100988	0	1.0
NC_005838_3	3.11|101025|36|NC_005838|CRISPRCasFinder,CRT	101025-101060	36	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146312-146347	0	1.0
NC_005838_3	3.11|101025|36|NC_005838|CRISPRCasFinder,CRT	101025-101060	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	101025-101060	0	1.0
NC_005838_3	3.12|101097|37|NC_005838|CRISPRCasFinder,CRT	101097-101133	37	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146384-146420	0	1.0
NC_005838_3	3.12|101097|37|NC_005838|CRISPRCasFinder,CRT	101097-101133	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	101097-101133	0	1.0
NC_005838_3	3.13|101170|37|NC_005838|CRISPRCasFinder,CRT	101170-101206	37	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146457-146493	0	1.0
NC_005838_3	3.13|101170|37|NC_005838|CRISPRCasFinder,CRT	101170-101206	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	101170-101206	0	1.0
NC_005838_3	3.14|101243|37|NC_005838|CRISPRCasFinder,CRT	101243-101279	37	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146530-146566	0	1.0
NC_005838_3	3.14|101243|37|NC_005838|CRISPRCasFinder,CRT	101243-101279	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	101243-101279	0	1.0
NC_005838_3	3.15|101316|38|NC_005838|CRISPRCasFinder,CRT	101316-101353	38	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146679-146716	0	1.0
NC_005838_3	3.15|101316|38|NC_005838|CRISPRCasFinder,CRT	101316-101353	38	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	101316-101353	0	1.0
NC_005838_3	3.16|101390|40|NC_005838|CRISPRCasFinder,CRT	101390-101429	40	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146753-146792	0	1.0
NC_005838_3	3.16|101390|40|NC_005838|CRISPRCasFinder,CRT	101390-101429	40	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	101390-101429	0	1.0
NC_005838_3	3.17|101466|41|NC_005838|CRISPRCasFinder,CRT	101466-101506	41	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146829-146869	0	1.0
NC_005838_3	3.17|101466|41|NC_005838|CRISPRCasFinder,CRT	101466-101506	41	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	101466-101506	0	1.0
NC_005838_3	3.18|101543|42|NC_005838|CRISPRCasFinder,CRT	101543-101584	42	NC_006462	Thermus thermophilus HB8 plasmid pTT27, complete sequence	146906-146947	0	1.0
NC_005838_3	3.18|101543|42|NC_005838|CRISPRCasFinder,CRT	101543-101584	42	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	101543-101584	0	1.0
NC_005838_4	4.1|131695|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT	131695-131732	38	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	131695-131732	0	1.0
NC_005838_4	4.2|131770|34|NC_005838|PILER-CR,CRISPRCasFinder,CRT	131770-131803	34	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	131770-131803	0	1.0
NC_005838_4	4.3|131841|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT	131841-131878	38	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	131841-131878	0	1.0
NC_005838_4	4.4|131916|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT	131916-131952	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	131916-131952	0	1.0
NC_005838_4	4.5|131990|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT	131990-132026	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	131990-132026	0	1.0
NC_005838_4	4.6|132064|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT	132064-132101	38	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	132064-132101	0	1.0
NC_005838_4	4.7|132139|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT	132139-132175	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	132139-132175	0	1.0
NC_005838_5	5.1|138681|35|NC_005838|PILER-CR	138681-138715	35	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138681-138715	0	1.0
NC_005838_5	5.2|138752|43|NC_005838|PILER-CR	138752-138794	43	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138752-138794	0	1.0
NC_005838_5	5.3|138831|36|NC_005838|PILER-CR	138831-138866	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138831-138866	0	1.0
NC_005838_5	5.3|138831|36|NC_005838|PILER-CR	138831-138866	36	NC_010878	Thermus sp. 4C plasmid pL4C, complete sequence	4325-4360	0	1.0
NC_005838_5	5.4|138903|39|NC_005838|PILER-CR	138903-138941	39	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138903-138941	0	1.0
NC_005838_5	5.5|138978|40|NC_005838|PILER-CR	138978-139017	40	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138978-139017	0	1.0
NC_005838_5	5.6|139054|40|NC_005838|PILER-CR	139054-139093	40	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	139054-139093	0	1.0
NC_005838_5	5.7|139130|34|NC_005838|PILER-CR	139130-139163	34	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	139130-139163	0	1.0
NC_005838_5	5.8|138682|34|NC_005838|CRISPRCasFinder	138682-138715	34	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138682-138715	0	1.0
NC_005838_5	5.9|138753|42|NC_005838|CRISPRCasFinder	138753-138794	42	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138753-138794	0	1.0
NC_005838_5	5.10|138832|35|NC_005838|CRISPRCasFinder	138832-138866	35	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138832-138866	0	1.0
NC_005838_5	5.10|138832|35|NC_005838|CRISPRCasFinder	138832-138866	35	NC_010878	Thermus sp. 4C plasmid pL4C, complete sequence	4325-4359	0	1.0
NC_005838_5	5.11|138904|38|NC_005838|CRISPRCasFinder	138904-138941	38	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138904-138941	0	1.0
NC_005838_5	5.12|138979|39|NC_005838|CRISPRCasFinder	138979-139017	39	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138979-139017	0	1.0
NC_005838_5	5.13|139055|39|NC_005838|CRISPRCasFinder	139055-139093	39	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	139055-139093	0	1.0
NC_005838_5	5.14|139131|33|NC_005838|CRISPRCasFinder	139131-139163	33	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	139131-139163	0	1.0
NC_005838_5	5.15|138682|41|NC_005838|CRT	138682-138722	41	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138682-138722	0	1.0
NC_005838_5	5.16|138753|49|NC_005838|CRT	138753-138801	49	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138753-138801	0	1.0
NC_005838_5	5.17|138832|42|NC_005838|CRT	138832-138873	42	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138832-138873	0	1.0
NC_005838_5	5.18|138904|45|NC_005838|CRT	138904-138948	45	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138904-138948	0	1.0
NC_005838_5	5.19|138979|46|NC_005838|CRT	138979-139024	46	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	138979-139024	0	1.0
NC_005838_5	5.20|139055|46|NC_005838|CRT	139055-139100	46	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	139055-139100	0	1.0
NC_005838_5	5.21|139131|40|NC_005838|CRT	139131-139170	40	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	139131-139170	0	1.0
NC_005838_6	6.1|153142|42|NC_005838|PILER-CR,CRISPRCasFinder,CRT	153142-153183	42	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	153142-153183	0	1.0
NC_005838_6	6.2|153220|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT	153220-153256	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	153220-153256	0	1.0
NC_005838_6	6.3|153293|40|NC_005838|PILER-CR,CRISPRCasFinder,CRT	153293-153332	40	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	153293-153332	0	1.0
NC_005838_6	6.4|153369|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT	153369-153405	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	153369-153405	0	1.0
NC_005838_6	6.5|153442|42|NC_005838|PILER-CR,CRISPRCasFinder,CRT	153442-153483	42	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	153442-153483	0	1.0
NC_005838_6	6.6|153520|44|NC_005838|CRISPRCasFinder,CRT	153520-153563	44	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	153520-153563	0	1.0
NC_005838_7	7.1|191924|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT	191924-191959	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	191924-191959	0	1.0
NC_005838_7	7.2|191996|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT	191996-192031	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	191996-192031	0	1.0
NC_005838_7	7.3|192068|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT	192068-192103	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	192068-192103	0	1.0
NC_005838_7	7.3|192068|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT	192068-192103	36	NZ_LR027519	Thermus thermophilus isolate TTHNAR1 plasmid 3, complete sequence	21548-21583	0	1.0
NC_005838_7	7.4|192140|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT	192140-192176	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	192140-192176	0	1.0
NC_005838_7	7.5|192213|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT	192213-192249	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	192213-192249	0	1.0
NC_005838_7	7.6|192286|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT	192286-192322	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	192286-192322	0	1.0
NC_005838_8	8.1|203258|36|NC_005838|CRISPRCasFinder,CRT	203258-203293	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203258-203293	0	1.0
NC_005838_8	8.2|203330|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203330-203364	35	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203330-203364	0	1.0
NC_005838_8	8.3|203401|38|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203401-203438	38	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203401-203438	0	1.0
NC_005838_8	8.4|203475|36|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203475-203510	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203475-203510	0	1.0
NC_005838_8	8.5|203547|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203547-203583	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203547-203583	0	1.0
NC_005838_8	8.6|203620|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203620-203656	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203620-203656	0	1.0
NC_005838_8	8.7|203693|34|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203693-203726	34	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203693-203726	0	1.0
NC_005838_8	8.8|203763|36|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203763-203798	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203763-203798	0	1.0
NC_005838_8	8.9|203835|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203835-203869	35	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203835-203869	0	1.0
NC_005838_8	8.10|203906|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203906-203942	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203906-203942	0	1.0
NC_005838_8	8.11|203979|38|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203979-204016	38	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	203979-204016	0	1.0
NC_005838_8	8.12|204053|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR	204053-204087	35	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	204053-204087	0	1.0
NC_005838_8	8.13|204124|36|NC_005838|CRISPRCasFinder,CRT	204124-204159	36	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	204124-204159	0	1.0
NC_005838_9	9.1|212681|39|NC_005838|CRISPRCasFinder,CRT	212681-212719	39	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	212681-212719	0	1.0
NC_005838_9	9.2|212756|41|NC_005838|CRISPRCasFinder,CRT,PILER-CR	212756-212796	41	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	212756-212796	0	1.0
NC_005838_9	9.3|212833|41|NC_005838|CRISPRCasFinder,CRT,PILER-CR	212833-212873	41	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	212833-212873	0	1.0
NC_005838_9	9.4|212910|45|NC_005838|CRISPRCasFinder,CRT,PILER-CR	212910-212954	45	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	212910-212954	0	1.0
NC_005838_9	9.5|212991|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR	212991-213027	37	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	212991-213027	0	1.0
NC_005838_9	9.6|213064|42|NC_005838|CRISPRCasFinder,CRT,PILER-CR	213064-213105	42	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	213064-213105	0	1.0
NC_005838_9	9.7|213142|40|NC_005838|CRISPRCasFinder,CRT,PILER-CR	213142-213181	40	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	213142-213181	0	1.0
NC_005838_9	9.8|213218|41|NC_005838|CRISPRCasFinder,CRT,PILER-CR	213218-213258	41	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	213218-213258	0	1.0
NC_005838_9	9.9|213295|40|NC_005838|CRISPRCasFinder,CRT,PILER-CR	213295-213334	40	NC_005838	Thermus thermophilus HB27 plasmid pTT27, complete sequence	213295-213334	0	1.0
NC_005838_1	1.1|2391|60|NC_005838|PILER-CR	2391-2450	60	NZ_AP019795	Thermus thermophilus strain AA2-29 plasmid pAA229, complete sequence	187867-187926	1	0.983
NC_005838_1	1.1|2391|60|NC_005838|PILER-CR	2391-2450	60	NZ_AP019793	Thermus thermophilus strain AA2-20 plasmid pAA220, complete sequence	217281-217340	1	0.983
NC_005838_1	1.1|2391|60|NC_005838|PILER-CR	2391-2450	60	NZ_CP014142	Thermus parvatiensis strain RL plasmid pTP143, complete sequence	71285-71344	1	0.983
NC_005838_1	1.1|2391|60|NC_005838|PILER-CR	2391-2450	60	NC_017588	Thermus thermophilus JL-18 plasmid pTTJL1801, complete sequence	157373-157432	1	0.983
NC_005838_1	1.1|2391|60|NC_005838|PILER-CR	2391-2450	60	NZ_LR027520	Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence	243415-243474	1	0.983
NC_005838_1	1.2|2490|60|NC_005838|PILER-CR	2490-2549	60	NC_017588	Thermus thermophilus JL-18 plasmid pTTJL1801, complete sequence	157472-157531	1	0.983
NC_005838_1	1.2|2490|60|NC_005838|PILER-CR	2490-2549	60	NZ_AP019795	Thermus thermophilus strain AA2-29 plasmid pAA229, complete sequence	187768-187827	1	0.983
NC_005838_1	1.2|2490|60|NC_005838|PILER-CR	2490-2549	60	NZ_AP019793	Thermus thermophilus strain AA2-20 plasmid pAA220, complete sequence	217182-217241	1	0.983
NC_005838_1	1.2|2490|60|NC_005838|PILER-CR	2490-2549	60	NZ_CP014142	Thermus parvatiensis strain RL plasmid pTP143, complete sequence	71384-71443	2	0.967
NC_005838_7	7.1|191924|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT	191924-191959	36	NC_004462	Thermus thermophilus phage IN93, complete genome	9327-9362	2	0.944
NC_005838_7	7.1|191924|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT	191924-191959	36	AB063393	Thermus thermophilus phage IN93 DNA, complete genome	9327-9362	2	0.944
NC_005838_7	7.3|192068|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT	192068-192103	36	NC_017590	Thermus thermophilus JL-18 plasmid pTTJL1802, complete sequence	46647-46682	2	0.944
NC_005838_5	5.6|139054|40|NC_005838|PILER-CR	139054-139093	40	NC_004462	Thermus thermophilus phage IN93, complete genome	10255-10294	3	0.925
NC_005838_5	5.6|139054|40|NC_005838|PILER-CR	139054-139093	40	AB063393	Thermus thermophilus phage IN93 DNA, complete genome	10255-10294	3	0.925
NC_005838_5	5.13|139055|39|NC_005838|CRISPRCasFinder	139055-139093	39	NC_004462	Thermus thermophilus phage IN93, complete genome	10255-10293	3	0.923
NC_005838_5	5.13|139055|39|NC_005838|CRISPRCasFinder	139055-139093	39	AB063393	Thermus thermophilus phage IN93 DNA, complete genome	10255-10293	3	0.923
NC_005838_5	5.17|138832|42|NC_005838|CRT	138832-138873	42	NC_010878	Thermus sp. 4C plasmid pL4C, complete sequence	4318-4359	5	0.881
NC_005838_8	8.9|203835|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203835-203869	35	NZ_AP022593	Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence	3545901-3545935	6	0.829
NC_005838_5	5.20|139055|46|NC_005838|CRT	139055-139100	46	NC_004462	Thermus thermophilus phage IN93, complete genome	10248-10293	8	0.826
NC_005838_5	5.20|139055|46|NC_005838|CRT	139055-139100	46	AB063393	Thermus thermophilus phage IN93 DNA, complete genome	10248-10293	8	0.826
NC_005838_8	8.9|203835|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203835-203869	35	NZ_CP017105	Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence	83960-83994	9	0.743
NC_005838_8	8.5|203547|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203547-203583	37	NZ_CP032343	Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence	208469-208505	10	0.73
NC_005838_8	8.5|203547|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203547-203583	37	NZ_CP032348	Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence	405598-405634	10	0.73
NC_005838_8	8.5|203547|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203547-203583	37	NZ_CP012917	Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence	519725-519761	10	0.73
NC_005838_8	8.9|203835|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR	203835-203869	35	MT897906	Arthrobacter phage Tweety19, complete genome	1818-1852	10	0.714

1. spacer 1.1|2391|60|NC_005838|PILER-CR matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgg	CRISPR spacer
ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgg	Protospacer
************************************************************

2. spacer 1.1|2391|60|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgg	CRISPR spacer
ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgg	Protospacer
************************************************************

3. spacer 1.2|2490|60|NC_005838|PILER-CR matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cgggtctccgtctcctggatctgccgccccagcctggcctccaggttctgaatccgactc	CRISPR spacer
cgggtctccgtctcctggatctgccgccccagcctggcctccaggttctgaatccgactc	Protospacer
************************************************************

4. spacer 1.2|2490|60|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cgggtctccgtctcctggatctgccgccccagcctggcctccaggttctgaatccgactc	CRISPR spacer
cgggtctccgtctcctggatctgccgccccagcctggcctccaggttctgaatccgactc	Protospacer
************************************************************

5. spacer 1.2|2490|60|NC_005838|PILER-CR matches to NZ_LR027520 (Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence) position: , mismatch: 0, identity: 1.0

cgggtctccgtctcctggatctgccgccccagcctggcctccaggttctgaatccgactc	CRISPR spacer
cgggtctccgtctcctggatctgccgccccagcctggcctccaggttctgaatccgactc	Protospacer
************************************************************

6. spacer 2.1|92194|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cgcgatgacgatgcagggcgccgagtgaaacgttaaag	CRISPR spacer
cgcgatgacgatgcagggcgccgagtgaaacgttaaag	Protospacer
**************************************

7. spacer 2.2|92268|41|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

atcaccttcttaggtgtcgggttcctttttgccgttctaac	CRISPR spacer
atcaccttcttaggtgtcgggttcctttttgccgttctaac	Protospacer
*****************************************

8. spacer 2.3|92345|44|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

accaagatgtagtcatccccaaagtccttgacgagcttagtcat	CRISPR spacer
accaagatgtagtcatccccaaagtccttgacgagcttagtcat	Protospacer
********************************************

9. spacer 3.1|100491|40|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ggggtatatcctctttatccccggtattcttgacaggtct	CRISPR spacer
ggggtatatcctctttatccccggtattcttgacaggtct	Protospacer
****************************************

10. spacer 3.2|100568|36|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tcacaaaatcgtacttgaggcaagcgaaagcgacga	CRISPR spacer
tcacaaaatcgtacttgaggcaagcgaaagcgacga	Protospacer
************************************

11. spacer 3.3|100641|37|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cctgagggggaggaggaggtggcttgcgggtaaaaaa	CRISPR spacer
cctgagggggaggaggaggtggcttgcgggtaaaaaa	Protospacer
*************************************

12. spacer 3.4|100490|41|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tggggtatatcctctttatccccggtattcttgacaggtct	CRISPR spacer
tggggtatatcctctttatccccggtattcttgacaggtct	Protospacer
*****************************************

13. spacer 3.5|100567|37|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ttcacaaaatcgtacttgaggcaagcgaaagcgacga	CRISPR spacer
ttcacaaaatcgtacttgaggcaagcgaaagcgacga	Protospacer
*************************************

14. spacer 3.6|100640|38|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccctgagggggaggaggaggtggcttgcgggtaaaaaa	CRISPR spacer
ccctgagggggaggaggaggtggcttgcgggtaaaaaa	Protospacer
**************************************

15. spacer 3.7|100714|42|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ttcgaagcgccccgccccgaggcacttcccacaccctttccc	CRISPR spacer
ttcgaagcgccccgccccgaggcacttcccacaccctttccc	Protospacer
******************************************

16. spacer 3.7|100714|42|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ttcgaagcgccccgccccgaggcacttcccacaccctttccc	CRISPR spacer
ttcgaagcgccccgccccgaggcacttcccacaccctttccc	Protospacer
******************************************

17. spacer 3.8|100792|44|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gtgctccttcaaactcctctccagagcctcctggatcagttcat	CRISPR spacer
gtgctccttcaaactcctctccagagcctcctggatcagttcat	Protospacer
********************************************

18. spacer 3.8|100792|44|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gtgctccttcaaactcctctccagagcctcctggatcagttcat	CRISPR spacer
gtgctccttcaaactcctctccagagcctcctggatcagttcat	Protospacer
********************************************

19. spacer 3.9|100872|41|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tcctctatcgccttggcgatgacgcccctgatggcctcgcg	CRISPR spacer
tcctctatcgccttggcgatgacgcccctgatggcctcgcg	Protospacer
*****************************************

20. spacer 3.10|100949|40|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

actccctctacgccccctaactcgcggtacgcgaagaggg	CRISPR spacer
actccctctacgccccctaactcgcggtacgcgaagaggg	Protospacer
****************************************

21. spacer 3.10|100949|40|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

actccctctacgccccctaactcgcggtacgcgaagaggg	CRISPR spacer
actccctctacgccccctaactcgcggtacgcgaagaggg	Protospacer
****************************************

22. spacer 3.11|101025|36|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gacaggtaagggtgtagaggtcgtccagcttcataa	CRISPR spacer
gacaggtaagggtgtagaggtcgtccagcttcataa	Protospacer
************************************

23. spacer 3.11|101025|36|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gacaggtaagggtgtagaggtcgtccagcttcataa	CRISPR spacer
gacaggtaagggtgtagaggtcgtccagcttcataa	Protospacer
************************************

24. spacer 3.12|101097|37|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

aagtgaggatgtacccccgccccttgagcttcttctc	CRISPR spacer
aagtgaggatgtacccccgccccttgagcttcttctc	Protospacer
*************************************

25. spacer 3.12|101097|37|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

aagtgaggatgtacccccgccccttgagcttcttctc	CRISPR spacer
aagtgaggatgtacccccgccccttgagcttcttctc	Protospacer
*************************************

26. spacer 3.13|101170|37|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ctttgcgccgcgcggcctagcgccgaccgcgtatccc	CRISPR spacer
ctttgcgccgcgcggcctagcgccgaccgcgtatccc	Protospacer
*************************************

27. spacer 3.13|101170|37|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ctttgcgccgcgcggcctagcgccgaccgcgtatccc	CRISPR spacer
ctttgcgccgcgcggcctagcgccgaccgcgtatccc	Protospacer
*************************************

28. spacer 3.14|101243|37|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ctttaagggagtcgccttcgcccacgtcttccttggt	CRISPR spacer
ctttaagggagtcgccttcgcccacgtcttccttggt	Protospacer
*************************************

29. spacer 3.14|101243|37|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ctttaagggagtcgccttcgcccacgtcttccttggt	CRISPR spacer
ctttaagggagtcgccttcgcccacgtcttccttggt	Protospacer
*************************************

30. spacer 3.15|101316|38|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gcgaggagccgccgcaccccgatgatgcgcccctggtc	CRISPR spacer
gcgaggagccgccgcaccccgatgatgcgcccctggtc	Protospacer
**************************************

31. spacer 3.15|101316|38|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gcgaggagccgccgcaccccgatgatgcgcccctggtc	CRISPR spacer
gcgaggagccgccgcaccccgatgatgcgcccctggtc	Protospacer
**************************************

32. spacer 3.16|101390|40|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tccttctttgggccagctgatgccccaggcaagccccggt	CRISPR spacer
tccttctttgggccagctgatgccccaggcaagccccggt	Protospacer
****************************************

33. spacer 3.16|101390|40|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tccttctttgggccagctgatgccccaggcaagccccggt	CRISPR spacer
tccttctttgggccagctgatgccccaggcaagccccggt	Protospacer
****************************************

34. spacer 3.17|101466|41|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gcttctccgttgcgctgagttcgccgttgctccagacatgg	CRISPR spacer
gcttctccgttgcgctgagttcgccgttgctccagacatgg	Protospacer
*****************************************

35. spacer 3.17|101466|41|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gcttctccgttgcgctgagttcgccgttgctccagacatgg	CRISPR spacer
gcttctccgttgcgctgagttcgccgttgctccagacatgg	Protospacer
*****************************************

36. spacer 3.18|101543|42|NC_005838|CRISPRCasFinder,CRT matches to NC_006462 (Thermus thermophilus HB8 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gtgtggccgcggctgcgcgccgcgcggcccttgcgcccatgc	CRISPR spacer
gtgtggccgcggctgcgcgccgcgcggcccttgcgcccatgc	Protospacer
******************************************

37. spacer 3.18|101543|42|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gtgtggccgcggctgcgcgccgcgcggcccttgcgcccatgc	CRISPR spacer
gtgtggccgcggctgcgcgccgcgcggcccttgcgcccatgc	Protospacer
******************************************

38. spacer 4.1|131695|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ctggccgcctggctcttaatgagctggagcacctggtg	CRISPR spacer
ctggccgcctggctcttaatgagctggagcacctggtg	Protospacer
**************************************

39. spacer 4.2|131770|34|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gcgctctccgcctgtaggtccaggccgaggacct	CRISPR spacer
gcgctctccgcctgtaggtccaggccgaggacct	Protospacer
**********************************

40. spacer 4.3|131841|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

acccagttgcccctaaccacccaatagaaccacccata	CRISPR spacer
acccagttgcccctaaccacccaatagaaccacccata	Protospacer
**************************************

41. spacer 4.4|131916|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccggggcgcgccggacgatctcccgcaggccctccac	CRISPR spacer
ccggggcgcgccggacgatctcccgcaggccctccac	Protospacer
*************************************

42. spacer 4.5|131990|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccccccctagtgggtcctccaccagggccccgccgca	CRISPR spacer
ccccccctagtgggtcctccaccagggccccgccgca	Protospacer
*************************************

43. spacer 4.6|132064|38|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

aggcggagctcggcgaggatctcctcgtggtggcggcg	CRISPR spacer
aggcggagctcggcgaggatctcctcgtggtggcggcg	Protospacer
**************************************

44. spacer 4.7|132139|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cctctaagacggccttctcacctatgacctcctccgg	CRISPR spacer
cctctaagacggccttctcacctatgacctcctccgg	Protospacer
*************************************

45. spacer 5.1|138681|35|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccccgcgcacccctccacggggcatagcaggtcat	CRISPR spacer
ccccgcgcacccctccacggggcatagcaggtcat	Protospacer
***********************************

46. spacer 5.2|138752|43|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cggggcgggccgccatatctgtacccgctctagagcaactgga	CRISPR spacer
cggggcgggccgccatatctgtacccgctctagagcaactgga	Protospacer
*******************************************

47. spacer 5.3|138831|36|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccgggaggaggcgctggaggtgcggagctacgaggc	CRISPR spacer
ccgggaggaggcgctggaggtgcggagctacgaggc	Protospacer
************************************

48. spacer 5.3|138831|36|NC_005838|PILER-CR matches to NC_010878 (Thermus sp. 4C plasmid pL4C, complete sequence) position: , mismatch: 0, identity: 1.0

ccgggaggaggcgctggaggtgcggagctacgaggc	CRISPR spacer
ccgggaggaggcgctggaggtgcggagctacgaggc	Protospacer
************************************

49. spacer 5.4|138903|39|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cccctcagggtccgttacttccacaaaagttttaaagtg	CRISPR spacer
cccctcagggtccgttacttccacaaaagttttaaagtg	Protospacer
***************************************

50. spacer 5.5|138978|40|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cgcacagctttcggacggtggctggcgaaacccccaactc	CRISPR spacer
cgcacagctttcggacggtggctggcgaaacccccaactc	Protospacer
****************************************

51. spacer 5.6|139054|40|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tatgcccaagaggttgagcacgctgcacctccttgccgat	CRISPR spacer
tatgcccaagaggttgagcacgctgcacctccttgccgat	Protospacer
****************************************

52. spacer 5.7|139130|34|NC_005838|PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cccgcccggtccctggagcaccagcctgtcccac	CRISPR spacer
cccgcccggtccctggagcaccagcctgtcccac	Protospacer
**********************************

53. spacer 5.8|138682|34|NC_005838|CRISPRCasFinder matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cccgcgcacccctccacggggcatagcaggtcat	CRISPR spacer
cccgcgcacccctccacggggcatagcaggtcat	Protospacer
**********************************

54. spacer 5.9|138753|42|NC_005838|CRISPRCasFinder matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ggggcgggccgccatatctgtacccgctctagagcaactgga	CRISPR spacer
ggggcgggccgccatatctgtacccgctctagagcaactgga	Protospacer
******************************************

55. spacer 5.10|138832|35|NC_005838|CRISPRCasFinder matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cgggaggaggcgctggaggtgcggagctacgaggc	CRISPR spacer
cgggaggaggcgctggaggtgcggagctacgaggc	Protospacer
***********************************

56. spacer 5.10|138832|35|NC_005838|CRISPRCasFinder matches to NC_010878 (Thermus sp. 4C plasmid pL4C, complete sequence) position: , mismatch: 0, identity: 1.0

cgggaggaggcgctggaggtgcggagctacgaggc	CRISPR spacer
cgggaggaggcgctggaggtgcggagctacgaggc	Protospacer
***********************************

57. spacer 5.11|138904|38|NC_005838|CRISPRCasFinder matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccctcagggtccgttacttccacaaaagttttaaagtg	CRISPR spacer
ccctcagggtccgttacttccacaaaagttttaaagtg	Protospacer
**************************************

58. spacer 5.12|138979|39|NC_005838|CRISPRCasFinder matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gcacagctttcggacggtggctggcgaaacccccaactc	CRISPR spacer
gcacagctttcggacggtggctggcgaaacccccaactc	Protospacer
***************************************

59. spacer 5.13|139055|39|NC_005838|CRISPRCasFinder matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

atgcccaagaggttgagcacgctgcacctccttgccgat	CRISPR spacer
atgcccaagaggttgagcacgctgcacctccttgccgat	Protospacer
***************************************

60. spacer 5.14|139131|33|NC_005838|CRISPRCasFinder matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccgcccggtccctggagcaccagcctgtcccac	CRISPR spacer
ccgcccggtccctggagcaccagcctgtcccac	Protospacer
*********************************

61. spacer 5.15|138682|41|NC_005838|CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cccgcgcacccctccacggggcatagcaggtcatgttgcat	CRISPR spacer
cccgcgcacccctccacggggcatagcaggtcatgttgcat	Protospacer
*****************************************

62. spacer 5.16|138753|49|NC_005838|CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ggggcgggccgccatatctgtacccgctctagagcaactggagttgcat	CRISPR spacer
ggggcgggccgccatatctgtacccgctctagagcaactggagttgcat	Protospacer
*************************************************

63. spacer 5.17|138832|42|NC_005838|CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cgggaggaggcgctggaggtgcggagctacgaggcgttgcac	CRISPR spacer
cgggaggaggcgctggaggtgcggagctacgaggcgttgcac	Protospacer
******************************************

64. spacer 5.18|138904|45|NC_005838|CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccctcagggtccgttacttccacaaaagttttaaagtggttgcac	CRISPR spacer
ccctcagggtccgttacttccacaaaagttttaaagtggttgcac	Protospacer
*********************************************

65. spacer 5.19|138979|46|NC_005838|CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gcacagctttcggacggtggctggcgaaacccccaactcgttgcac	CRISPR spacer
gcacagctttcggacggtggctggcgaaacccccaactcgttgcac	Protospacer
**********************************************

66. spacer 5.20|139055|46|NC_005838|CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

atgcccaagaggttgagcacgctgcacctccttgccgatgttgcac	CRISPR spacer
atgcccaagaggttgagcacgctgcacctccttgccgatgttgcac	Protospacer
**********************************************

67. spacer 5.21|139131|40|NC_005838|CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccgcccggtccctggagcaccagcctgtcccacgttgcac	CRISPR spacer
ccgcccggtccctggagcaccagcctgtcccacgttgcac	Protospacer
****************************************

68. spacer 6.1|153142|42|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ggcccctgacgaggttcctaggtgaggtcggtctccttctgg	CRISPR spacer
ggcccctgacgaggttcctaggtgaggtcggtctccttctgg	Protospacer
******************************************

69. spacer 6.2|153220|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cccccgtgtgggaggtggacctggggggcctcgagat	CRISPR spacer
cccccgtgtgggaggtggacctggggggcctcgagat	Protospacer
*************************************

70. spacer 6.3|153293|40|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gctccgggtgggccccgtcctcctcgggcccgagaggaga	CRISPR spacer
gctccgggtgggccccgtcctcctcgggcccgagaggaga	Protospacer
****************************************

71. spacer 6.4|153369|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tgatgctgatcattgctcacctcctgcccggaggtgg	CRISPR spacer
tgatgctgatcattgctcacctcctgcccggaggtgg	Protospacer
*************************************

72. spacer 6.5|153442|42|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

aaatgcggtcctggagtgggaatacaacgaagtttccgttca	CRISPR spacer
aaatgcggtcctggagtgggaatacaacgaagtttccgttca	Protospacer
******************************************

73. spacer 6.6|153520|44|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

acggtaccggcgaaggacttggccacaccttgaatgaccgtcat	CRISPR spacer
acggtaccggcgaaggacttggccacaccttgaatgaccgtcat	Protospacer
********************************************

74. spacer 7.1|191924|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

accgccaccgccaagatccaagcgccctgcatccct	CRISPR spacer
accgccaccgccaagatccaagcgccctgcatccct	Protospacer
************************************

75. spacer 7.2|191996|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gatggcgaggacggccacgttgaggtcccgggccag	CRISPR spacer
gatggcgaggacggccacgttgaggtcccgggccag	Protospacer
************************************

76. spacer 7.3|192068|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gagggaggctggtaggactccatgccggggtagcgg	CRISPR spacer
gagggaggctggtaggactccatgccggggtagcgg	Protospacer
************************************

77. spacer 7.3|192068|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NZ_LR027519 (Thermus thermophilus isolate TTHNAR1 plasmid 3, complete sequence) position: , mismatch: 0, identity: 1.0

gagggaggctggtaggactccatgccggggtagcgg	CRISPR spacer
gagggaggctggtaggactccatgccggggtagcgg	Protospacer
************************************

78. spacer 7.4|192140|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tctccctgggccggatgcggtgccccctccggtcccc	CRISPR spacer
tctccctgggccggatgcggtgccccctccggtcccc	Protospacer
*************************************

79. spacer 7.5|192213|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cctatctcgtcttccgcctctggaacttctccgacac	CRISPR spacer
cctatctcgtcttccgcctctggaacttctccgacac	Protospacer
*************************************

80. spacer 7.6|192286|37|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tcagtataccacagctctgcggcgggtgctggagaag	CRISPR spacer
tcagtataccacagctctgcggcgggtgctggagaag	Protospacer
*************************************

81. spacer 8.1|203258|36|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tccggctcgtgaacggcgagattcagatcattcccg	CRISPR spacer
tccggctcgtgaacggcgagattcagatcattcccg	Protospacer
************************************

82. spacer 8.2|203330|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

catcacctcggcccgggccaggaccacccccaccc	CRISPR spacer
catcacctcggcccgggccaggaccacccccaccc	Protospacer
***********************************

83. spacer 8.3|203401|38|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccgcctggctcgccggccccatcgcccgcctctggcag	CRISPR spacer
ccgcctggctcgccggccccatcgcccgcctctggcag	Protospacer
**************************************

84. spacer 8.4|203475|36|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cgctatggaccgaaacgactgcccactcgcgagcgc	CRISPR spacer
cgctatggaccgaaacgactgcccactcgcgagcgc	Protospacer
************************************

85. spacer 8.5|203547|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

aacacagcgtagaccgtaacggcccccagcgcgatgc	CRISPR spacer
aacacagcgtagaccgtaacggcccccagcgcgatgc	Protospacer
*************************************

86. spacer 8.6|203620|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccgaaccgccgcctcagcgcggtgaggacctcgccca	CRISPR spacer
ccgaaccgccgcctcagcgcggtgaggacctcgccca	Protospacer
*************************************

87. spacer 8.7|203693|34|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gtgcggctcgtgaccaagtagccatggggtactt	CRISPR spacer
gtgcggctcgtgaccaagtagccatggggtactt	Protospacer
**********************************

88. spacer 8.8|203763|36|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ttcggaacccgcctggagtacgccccatatcagcag	CRISPR spacer
ttcggaacccgcctggagtacgccccatatcagcag	Protospacer
************************************

89. spacer 8.9|203835|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cgctgggcggggatcgcggcgagcgtggtcctccc	CRISPR spacer
cgctgggcggggatcgcggcgagcgtggtcctccc	Protospacer
***********************************

90. spacer 8.10|203906|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tgtacgccctgcgaaactttgtgctccaaagcgtggt	CRISPR spacer
tgtacgccctgcgaaactttgtgctccaaagcgtggt	Protospacer
*************************************

91. spacer 8.11|203979|38|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

agggcctcgaggcccttcaccaggaggccgaggcggcg	CRISPR spacer
agggcctcgaggcccttcaccaggaggccgaggcggcg	Protospacer
**************************************

92. spacer 8.12|204053|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ctgagggagctggtaaacgagcttgggaacgcctg	CRISPR spacer
ctgagggagctggtaaacgagcttgggaacgcctg	Protospacer
***********************************

93. spacer 8.13|204124|36|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

attcgccgcctcccagtagccgcgccaccacctcag	CRISPR spacer
attcgccgcctcccagtagccgcgccaccacctcag	Protospacer
************************************

94. spacer 9.1|212681|39|NC_005838|CRISPRCasFinder,CRT matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

tcaggaaactaaggcccaggacaaacccgttgcctacaa	CRISPR spacer
tcaggaaactaaggcccaggacaaacccgttgcctacaa	Protospacer
***************************************

95. spacer 9.2|212756|41|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

aaggcaggggagttcggcaagaagcttgagcagtacttcaa	CRISPR spacer
aaggcaggggagttcggcaagaagcttgagcagtacttcaa	Protospacer
*****************************************

96. spacer 9.3|212833|41|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

agaagccctctacacgggcgaagaagccctctacacgtacg	CRISPR spacer
agaagccctctacacgggcgaagaagccctctacacgtacg	Protospacer
*****************************************

97. spacer 9.4|212910|45|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

atttgaaagaggcgaaaccagggccctcctccctgggtcgcaatc	CRISPR spacer
atttgaaagaggcgaaaccagggccctcctccctgggtcgcaatc	Protospacer
*********************************************

98. spacer 9.5|212991|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ccctagtggaggtgagccttgaggcgtaagctgaagt	CRISPR spacer
ccctagtggaggtgagccttgaggcgtaagctgaagt	Protospacer
*************************************

99. spacer 9.6|213064|42|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

cgagggcgatcctcgcactcaggccagaaggcagtccagaaa	CRISPR spacer
cgagggcgatcctcgcactcaggccagaaggcagtccagaaa	Protospacer
******************************************

100. spacer 9.7|213142|40|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

gtaaggtgttaagaagcgtgtttttcggacttggggcggc	CRISPR spacer
gtaaggtgttaagaagcgtgtttttcggacttggggcggc	Protospacer
****************************************

101. spacer 9.8|213218|41|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

ggaggccttgtcggaccccgaggccgcccctctcgcccggg	CRISPR spacer
ggaggccttgtcggaccccgaggccgcccctctcgcccggg	Protospacer
*****************************************

102. spacer 9.9|213295|40|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NC_005838 (Thermus thermophilus HB27 plasmid pTT27, complete sequence) position: , mismatch: 0, identity: 1.0

taagccccaaggaagggagtttgcgtggatcctgaaagag	CRISPR spacer
taagccccaaggaagggagtttgcgtggatcctgaaagag	Protospacer
****************************************

103. spacer 1.1|2391|60|NC_005838|PILER-CR matches to NZ_AP019795 (Thermus thermophilus strain AA2-29 plasmid pAA229, complete sequence) position: , mismatch: 1, identity: 0.983

ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgg	CRISPR spacer
ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgc	Protospacer
*********************************************************** 

104. spacer 1.1|2391|60|NC_005838|PILER-CR matches to NZ_AP019793 (Thermus thermophilus strain AA2-20 plasmid pAA220, complete sequence) position: , mismatch: 1, identity: 0.983

ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgg	CRISPR spacer
ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgc	Protospacer
*********************************************************** 

105. spacer 1.1|2391|60|NC_005838|PILER-CR matches to NZ_CP014142 (Thermus parvatiensis strain RL plasmid pTP143, complete sequence) position: , mismatch: 1, identity: 0.983

ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgg	CRISPR spacer
ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgc	Protospacer
*********************************************************** 

106. spacer 1.1|2391|60|NC_005838|PILER-CR matches to NC_017588 (Thermus thermophilus JL-18 plasmid pTTJL1801, complete sequence) position: , mismatch: 1, identity: 0.983

ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgg	CRISPR spacer
ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgc	Protospacer
*********************************************************** 

107. spacer 1.1|2391|60|NC_005838|PILER-CR matches to NZ_LR027520 (Thermus thermophilus isolate TTHNAR1 plasmid 4, complete sequence) position: , mismatch: 1, identity: 0.983

ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgg	CRISPR spacer
ttggtttccaccgcgtggatccgggcctccagttgggcctccgtctcttggatctgccgc	Protospacer
*********************************************************** 

108. spacer 1.2|2490|60|NC_005838|PILER-CR matches to NC_017588 (Thermus thermophilus JL-18 plasmid pTTJL1801, complete sequence) position: , mismatch: 1, identity: 0.983

cgggtctccgtctcctggatctgccgccccagcctggcctccaggttctgaatccgactc	CRISPR spacer
cgggtctccgtctcctggatctgccgctccagcctggcctccaggttctgaatccgactc	Protospacer
***************************.********************************

109. spacer 1.2|2490|60|NC_005838|PILER-CR matches to NZ_AP019795 (Thermus thermophilus strain AA2-29 plasmid pAA229, complete sequence) position: , mismatch: 1, identity: 0.983

cgggtctccgtctcctggatctgccgccccagcctggcctccaggttctgaatccgactc	CRISPR spacer
cgggtctccgtctcctggatctgccgctccagcctggcctccaggttctgaatccgactc	Protospacer
***************************.********************************

110. spacer 1.2|2490|60|NC_005838|PILER-CR matches to NZ_AP019793 (Thermus thermophilus strain AA2-20 plasmid pAA220, complete sequence) position: , mismatch: 1, identity: 0.983

cgggtctccgtctcctggatctgccgccccagcctggcctccaggttctgaatccgactc	CRISPR spacer
cgggtctccgtctcctggatctgccgctccagcctggcctccaggttctgaatccgactc	Protospacer
***************************.********************************

111. spacer 1.2|2490|60|NC_005838|PILER-CR matches to NZ_CP014142 (Thermus parvatiensis strain RL plasmid pTP143, complete sequence) position: , mismatch: 2, identity: 0.967

cgggtctccgtctcctggatctgccgccccagcctggcctccaggttctgaatccgactc	CRISPR spacer
cgggtctccgtctcctggatctgccgctccagcctggcctccaggttttgaatccgactc	Protospacer
***************************.*******************.************

112. spacer 7.1|191924|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_004462 (Thermus thermophilus phage IN93, complete genome) position: , mismatch: 2, identity: 0.944

accgccaccgccaagatccaagcgccctgcatccct	CRISPR spacer
accgccaccgccacgatccaagcgccctgcatccgt	Protospacer
************* ******************** *

113. spacer 7.1|191924|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to AB063393 (Thermus thermophilus phage IN93 DNA, complete genome) position: , mismatch: 2, identity: 0.944

accgccaccgccaagatccaagcgccctgcatccct	CRISPR spacer
accgccaccgccacgatccaagcgccctgcatccgt	Protospacer
************* ******************** *

114. spacer 7.3|192068|36|NC_005838|PILER-CR,CRISPRCasFinder,CRT matches to NC_017590 (Thermus thermophilus JL-18 plasmid pTTJL1802, complete sequence) position: , mismatch: 2, identity: 0.944

gagggaggctggtaggactccatgccggggtagcgg	CRISPR spacer
gagggaggccggtaggactccatgccgggatagcgg	Protospacer
*********.*******************.******

115. spacer 5.6|139054|40|NC_005838|PILER-CR matches to NC_004462 (Thermus thermophilus phage IN93, complete genome) position: , mismatch: 3, identity: 0.925

tatgcccaagaggttgagcacgctgcacctccttgccgat	CRISPR spacer
tatgcccaagaggttgagcacgctgcacctccttgccccc	Protospacer
*************************************  .

116. spacer 5.6|139054|40|NC_005838|PILER-CR matches to AB063393 (Thermus thermophilus phage IN93 DNA, complete genome) position: , mismatch: 3, identity: 0.925

tatgcccaagaggttgagcacgctgcacctccttgccgat	CRISPR spacer
tatgcccaagaggttgagcacgctgcacctccttgccccc	Protospacer
*************************************  .

117. spacer 5.13|139055|39|NC_005838|CRISPRCasFinder matches to NC_004462 (Thermus thermophilus phage IN93, complete genome) position: , mismatch: 3, identity: 0.923

atgcccaagaggttgagcacgctgcacctccttgccgat	CRISPR spacer
atgcccaagaggttgagcacgctgcacctccttgccccc	Protospacer
************************************  .

118. spacer 5.13|139055|39|NC_005838|CRISPRCasFinder matches to AB063393 (Thermus thermophilus phage IN93 DNA, complete genome) position: , mismatch: 3, identity: 0.923

atgcccaagaggttgagcacgctgcacctccttgccgat	CRISPR spacer
atgcccaagaggttgagcacgctgcacctccttgccccc	Protospacer
************************************  .

119. spacer 5.17|138832|42|NC_005838|CRT matches to NC_010878 (Thermus sp. 4C plasmid pL4C, complete sequence) position: , mismatch: 5, identity: 0.881

cgggaggaggcgctggaggtgcggagctacgaggcgttgcac	CRISPR spacer
cgggaggaggcgctggaggtgcggagctacgaggcctcgggg	Protospacer
*********************************** *.* . 

120. spacer 8.9|203835|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NZ_AP022593 (Mycolicibacterium arabiense strain JCM 18538 plasmid pJCM18538, complete sequence) position: , mismatch: 6, identity: 0.829

-cgctgggcggggatcgcggcgagcgtggtcctccc	CRISPR spacer
acactcgac-gggatcgcggcgggcgtggccctccc	Protospacer
 *.** *.* ************.******.******

121. spacer 5.20|139055|46|NC_005838|CRT matches to NC_004462 (Thermus thermophilus phage IN93, complete genome) position: , mismatch: 8, identity: 0.826

atgcccaagaggttgagcacgctgcacctccttgccgatgttgcac-------	CRISPR spacer
atgcccaagaggttgagcacgctgcacctccttgcc-------ccccagcctg	Protospacer
************************************       * *       

122. spacer 5.20|139055|46|NC_005838|CRT matches to AB063393 (Thermus thermophilus phage IN93 DNA, complete genome) position: , mismatch: 8, identity: 0.826

atgcccaagaggttgagcacgctgcacctccttgccgatgttgcac-------	CRISPR spacer
atgcccaagaggttgagcacgctgcacctccttgcc-------ccccagcctg	Protospacer
************************************       * *       

123. spacer 8.9|203835|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP017105 (Rhizobium gallicum strain IE4872 plasmid pRgalIE4872d, complete sequence) position: , mismatch: 9, identity: 0.743

cgctgggcggggatcgcggcgagcgtggtcctccc	CRISPR spacer
cgctgggcggggattgcggcgcgcgtgctttggaa	Protospacer
**************.****** ***** *..    

124. spacer 8.5|203547|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP032343 (Azospirillum brasilense strain MTCC4038 plasmid p4, complete sequence) position: , mismatch: 10, identity: 0.73

aacacagcgtagaccgtaacggcccccagcgcgatgc	CRISPR spacer
gtcaggatgacgaccgtcacggccgccagcgcgatgc	Protospacer
. ** ...*  ****** ****** ************

125. spacer 8.5|203547|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP032348 (Azospirillum brasilense strain MTCC4039 plasmid p4, complete sequence) position: , mismatch: 10, identity: 0.73

aacacagcgtagaccgtaacggcccccagcgcgatgc	CRISPR spacer
gtcaggatgacgaccgtcacggccgccagcgcgatgc	Protospacer
. ** ...*  ****** ****** ************

126. spacer 8.5|203547|37|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to NZ_CP012917 (Azospirillum brasilense strain Sp 7 plasmid ABSP7_p3, complete sequence) position: , mismatch: 10, identity: 0.73

aacacagcgtagaccgtaacggcccccagcgcgatgc	CRISPR spacer
gtcaggatgacgaccgtcacggccgccagcgcgatgc	Protospacer
. ** ...*  ****** ****** ************

127. spacer 8.9|203835|35|NC_005838|CRISPRCasFinder,CRT,PILER-CR matches to MT897906 (Arthrobacter phage Tweety19, complete genome) position: , mismatch: 10, identity: 0.714

cgctgggcggggatcgcggcgagcgtggtcctccc	CRISPR spacer
cacatggcgcggatcgcggcgagcgtgttctcggt	Protospacer
*.*  **** ***************** **..  .

Prophage detection

Region	Region Position	Protein_number	Hit_taxonomy	Key_proteins	Att_site
DBSCAN-SWA_1	57604 : 92104	34	Leptospira_phage(50.0%)	transposase	NA

Sequences of DBSCAN-SWA_1

Nucleotide sequences of DBSCAN-SWA_1

>NC_005838|57604:92104|DBSCAN-SWA
CCTAGTAAATTGCCTTGTACCCCGGAGGGGGCGGGAGAAGGGAGAGAAGAACCCTAAGGCCGTAGGCGATGAGCTCCAAAAGCGCCCGCGCCATGGCCGTCCAAGGCTTCCGCTCCCAAAGGTACCCCCCACCCAGCCGCGTCTTCATCCCCCCAAACACCCCCTCCACCACCCCGCGAAACCGGTACACCTCGGGGTCCCACCCCTCCCGCGCCCGCACCCGCGCCTCCTCCCTGGCCTCGCCCCCGCCCCGAAGCCGGATCACCGGCCGCACCCCCGCCTCCCCCAAAACCCCCCACACCTCCTTCCCGTCAAACCCCGCGTCCGCCAAAAGCCACCCTCGGGAAGGAGGAAACCGCCTCAGCACCTCCCCCCCAAGCCGGGGGTCCGGGGCGTAGCCCTCCCCCACCACTCCACCCCAGGGCCACAAGAGCCGCCTCTCCCTATCCCACCGCATCAGGGCCAGAAGCCGCGCGTGCCCCCGCACCCGCCGCACCTCCTTCCCCCGACGAAAGCGGAGAAGCCGGTCCTTGCTCCGGTAGGCCAGCCCCGTGGTGTCCATGAGGTAGAGGGGGGGAAAGCGCCGCCAGGTGTGCCGGCGCCTCGTCCGAAGCCGCTTCGCCTTCCGGCGAGGACTCCGGGGCGAGATGGGCCTCCAGTTCCCGGGAAAGCCTCTCCAGGAGGGCCTCAAGGAGTTTGGGGTCCAGGTGCTTGAGGGCGTAGCGGGCCAGGGACTGGTGGGAAGGGAAGGGGCCTTCCATCAGGTCCTGGAGTGAGGCCTCCGTCTCGCGGTAGGTGAGGTGGAAGAAGGCGCGGAAGAGAAGGAGGGCCAGGTAAAGGGCGTGGCTGTAGCGCCAGGGGCGGCCCCGCTTGCCTTTGGGGGTGGGAGGGGCCACCTCCCGGGCCAGGCGCAGGCAGTGTTCCAGGACCTCCTTGGGGCTTGCCTCCCTGCGAAGGAAGCCTCGCTTGCCCATCAGGAGAGAGATATACACCCGTCCTCCTGACCTTTGCAAGGCAAGCCCACTCCAAGAGGCCAAAGCCCGCTTTTCCGAGGTGGTGGAGCGGGCCCTCAAGGGGGAGCCCCAGCTCGTCCTCCGGCGGGGTAAGAAGGCGGTGGTGGTGCTGGACTGGGAGACCTACGCCCGGCTCACCGGGGAAGAGGCCTCGGTCCTCGAGGCCCTAAGACCCCCCAAGACCCTCCCCAATGAGGAGGTGGAAGCCCTCTTCCAAAGGCAAAAGACGGGCTTCCGGGAGGTGGACTTCTGAGGTACCTGCTGGACACCAACGTGGTCTCCGAGGCCGTCAAGCGGCGGCCTCACCCCAAGGTGGTGGCCTTCCTGCGCCACCTTAAAGTGGGGGAGGCGTACCTCTCCGCCCTCACCTTGGGCGAACTGGTCCAGGGGGTGGCCCGGGCCCCGGAGGCCCGAAGGGCCATCCTCAGCCGATGGCTCTCGGGGCTGAAGGCGAGCTTCTCGGGGCGGATCCTTCCCCTGGACGCCGAGGTGATGGAGCTCTGGGGCGAGCTCACCGGAAACGCCATGAGGGAGGGCAAGCCCCTCTCTCCCCTAGACGCCATGCTGGCGGCCACGGCCCTGCGGCACGGCCTGATCCTGGCCACCCGGAACACCGAGGAGTTCCGCCACGTTCCCGTGCCCCTCGTGAACCCCTGGGAAGGGTAACCCTAGGCGGCCTCACAGGCCCACCTTCTCCTCCGGGGCAATCCCTGTGTGGGCCAGGCCCAACTCAGCGGGGGAGTGGCCTGGTAGACTCCTCCCCATGCGGGCCATCGTCATCGGAAGCGGGGTAGGAGGGCTCTCTGTGGCCATCCGCCTCGCCGCCATGGGCCTTCAGGTCCTGGTCCTGGAGAAGCTCCCGGGGCCCGGAGGCCGGGCCTTCGTCCACCGGGCGGAGGGCTTCACCTTTGACATGGGGCCCACGGTGATCACCGTCCCCCCCTTCCTGGAGGACCTCTTCGCCACCGCTCCAGGCGACCCCAGGCTCTACCCCGACTTCCCCGAGGAGGAAGGGCTTAAGCACACGGAGCGCTACGTGAAGCTCGTCCCCTTGGACCCCTTCTACCGCCTCCACTTCCCGGACGGCACCTACTTTGACTACAAGGACGACCCCGAGCACCTGGAGGGCGAGGTGGCCCGCCTCGCCCCGGAGGACCTCGAGGGCTACCGCCGCTTTGAGGCCCACGCCAAGGCCCTCTTCCAGAAGGGCTTTCTGGAACTCGGCTTCACCCACTTCGGAAGCCTCCTGGACCTCCTCAAGGTGGCCCCGGACCTCCTCCGCCTGGACGCGGTGCGGCCCCTTTTCGGCGTGGTCTCCCGCTACTTCAAGAACCCCAAGACCCGGCAGATCTTCTCCTTTGAGCCCCTCCTCATCGGAGGGAACCCCCTCCAGGTGCCCGCCCTCTACGCCATGATCCACTTCGTGGAGCGGCGCTGGGGGGTGCACTTCGCCATGGGGGGGACGGGGGCCTTGGTGCGGGGGCTCGTCAGGAAGCTGGAGGAGCTTGGCGGGGAGATCCGCTATGGCGCCCCCGTGCGCCGCATCCTCACCAAGGGGCGGCGCGCCGTGGGGGTGGTCCTCCAGGACGGGGAGAAGCTCGCGGCCGACCTCGTGGTCTCCAACGCCGACTACGTCCACACCTACGGCGAGCTCCTCGCCCCCGAGGACCGCACCTGGAACGGCGACTGGCGCCTCAAGCGCACCCGGCTCTCCATGAGCCTCTTCGTGGCCTACTTCGGCTTCCGGGCCCGGGGGGACGAGGGGGAAAGGCTTAGGCACCACAACGTCCTCTTCTCCCACCGCTACGAGGGGCTTCTCCGGGACATCTTCTGGCGGAAGGTCCTCCCCGAGGACCTCGCCCACTACCTCCACCTCCCCACCCTCACCGACCCCTCCCTGGCCCCCCCCGGGCACCACGCCGCCTACACCCTGGTCCCTGTACCCCACAACGGGAGCGGCCTGGACTGGGGGAGGCTCGGCCCAGCGTACCTGGAAAAGGCCCTCCGTTACTTGGACGAGGCGGGGTACCTCCCCGGGCTCATGGACCGCCTGGTCTACACCCACTTCATCACCCCGGACTACTTCCAGTGGACCCTGAATAGCCACCTGGGCAACGCCTTCGGTCCCGAGCCCGTGCTCTGGCAGACGGCCTCCTTCAGGCCCAAGAACCGCTCCGAGGACGTGAAGGGGCTCTACCTGGTGGGGCAGAGCTACCAGCCGGGGGCAGGGCTTCCCAGCGTGATGATGTCCGCCAAGATCACGGCCCGGCTCATCGCCCACGACCTGGGCCTGGAAAAGGCCCCTAAGGGCCTTCTGGAGGCGCGGGGGTGAACATCCGGGAGAGGAAGCGGAAGCACCTCGAGGCCTGCCTGGAAGGCGAGGTGGCCTACCAGAAGACCACCACGGGGCTGGAAGGCTTCCGCCTCCGCTACCAGGCCCTGGCGGGCCTCGCCCTAGGCGAGGTGGACCTCACCACCCCCTTCCTGGGGAAGACCCTGAAGGCCCCCTTCCTCATCGGGGCCATGACCGGGGGGGAGGAAAACGGGGAGAGGATCAACCTGGCCCTGGCGGAGGCCGCGGAGGCCTTAGGGGTGGGGATGATGCTGGGCTCGGGCAGGATCCTTCTGGAGCGCCCCGAGGCCCTAAGGAGCTTCCGGGTGCGGAAGGTGGCCCCAAAGGCGCTCCTCATCGCCAACCTGGGCCTCGCCCAGCTCAGGCGCTACGGGCGGGACGACCTCCTCCGGCTCGTGGAGGCCCTGGAGGCGGACGCCCTCGCCTTCCACGTGAACCCCCTGCAGGAGGCGGTGCAGCGGGGGGACACGGACTTCCGGGGCCTGGTGGAGAGGCTCGCCGAACTCCTCCCCCTCCCCTTCCCCGTGATGGTGAAGGAGGTGGGGCACGGCCTCTCCCGGGAGGCGGCCTTGGCCCTACGGGACCTCCCCTTGGCGGCGGTGGACGTGGCCGGGGCCGGGGGGACGAGCTGGGCCCGGGTGGAGGAGTGGGTGCGCTTCGGGGAGGTGCGCCACCCGGAGCTCTGCGAGATCGGGATCCCCACGGCGAGGGCCATCCTCGAGGTGCGGGAGGTCCTGCCCCACCTCCCCCTCGTGGCCTCCGGCGGGGTCTACACGGGGACGGACGGGGCCAAGGCCCTGGCCCTGGGGGCGGACCTCTTGGCGGTGGCGCGCCCCCTCCTCAGGCCCGCCCTGGAGGGGGCGGAAAGGGTGGCGGCCTGGATCGGGGACTACCTGGAAGAACTTAGGACCGCCCTCTTCGCCATCGGGGCCAAGAACCCGAAGGAAGCCCGGGGGCGGGTGGAGCGGGTGTAGACTGGAGGCGTGAGGGCCCCGGAAGAAAGCCTTCGCGAAGTCCTCGCCCGCTTTCCCCAGGTCCAGGCCGCCTTCCTCTTCGGCTCCCGCGCCGAGGGAAGGGCGCGAGCGGACAGCGATTGGGACCTCGCCCTCCTCCTCTCCCCGGAGGAGCCCGACCCCACCCTCGAGGTCCTGGGAGCCCTGGTGGAAGCGGGGCTGGAACGGGTAGACCTGGTCCTCCTCCACCGGGCCCCGCCCCTTCTCGCCTTCCTCGCCGTGAAGGGGAAGCCCGTCTTTCTCCGCGAAGGTTTTGACCTCGGAAGCTACGTCTCCCGCGTGGCCCGGGAGTGGTGGGACACCGAGCCCCTTCTCCGGGTCCAGCGGGAGGCCCTGAAACGGAGGTGGCTTGACCCGTCCTGAGGCCCTGGGCCGGGCCTTCGCCCGGTTCCTCTAGGCCCCGGGGACGTGCATCAGGGCCCGGGGGTACGGCTCCAGAAGGGCCTGGGCCTCCACGTAGGGCTCGGCGAAGCGCCGGGCCCAGGAGGCGAGGAGGGCCAGGGGGGCCTCGAGGGGCAGGCGCTCCTCGCGGAAGTCCGCAAGGAGATCCAGGAAGTGGGCCTTCTCCCTTGGGGCGAGGGCCTTCTTGAAGAAGCCGAAGGCGTGGAGGAGGGCGTCCGCCATGGCCCCGAGACGCCAGGGCCTCTCCGTGGCCCGCAAGAACCCCTCCTCGTAGGCCCCATGGACCTCGGGAAAGGGCCTCCCCCTAGCCCCGGCGAGGAGGCGGCCCAGGGCCCTCGCCTCCTTCTGGTTATAAGCCAGGAGGAGGAGCTTGTAACGGGCGTGGAAGGCCATGAGGCCGGGGAGGTCCTCCACCCGCCGAAGCCGGGCCAGGGCGAAGATGCGGGTGAAGAAGTGGGCCCGGATGCGAGGGTTGGTGAGCCTCCCCTCGTCCTCCTTGGGAAGGAGGGGGAAGGCCTCCTCCACCGCCTGGGCGAAAAGCCCGGGGCCTTTCCCCACCACCCCGCCCCCCTCGGCGTGAGCGTAGCGCTTGGCGTCCTTCAGGGCGCAGGAGGGGGAGCGGTTCTTGAGGAGGAAGCCCTCCACCTCCCCGAGGCCCTGGAGGAAGCGCTGGCTGAAGGCCCGCATCCTCTCCGTGAGGTCCTCCCCCGTCTTGGGCTGGACCATCCTCGGGCCCTCCTCCCCCCGCACCAGGCGCACCACGGGCCTCGGCACCCCGAGGCCGATCTCCACCTCCGGGCAGACGGGGACGAAGTCCACGTGCTCCTTTAGGGCCGCCACCACCTTGTCGGGGATGAGCTCCCCCGAGTAGCGCACCGCGGCGAACCCCAGGCAGGCGCTCACCACGACGCGGGGCCTGGGCCACTCCCCTGGGCTCATGGGTACCCCCCGGAGGGCCGCCCCGCCCTGCCCCAAAGGGCGGCGGCGAGGGCGAGGCCCACAAGAAGCGCCGCGCCCCAGGTGGCCAGGGTCACGAAGCCGCTGTTGGGGAAGCGCACGCCGATGCCCACGAGGGCCCAAAGGAGGACGGCAAGAAACACCCCCTCCCGTTCGCGAAGGGCCAGGAGCCACGCCAGGGCCACCACCAGGGCGAGGGCGACGCCCATCCACGCCTCCTGGGAAAGCCCCCAGCCGGACCATCCCGCGTAGTCCAGAACCGCGGTGACGTTCGCGATGGTGGCCACGGAGATCCAGCCCAGGTAGAGGCTGAAGGGCGCGTCCACAAGCCAGCGCTCCCAGGGACTCGAGGGCCCCAGCCCACGCCGCAGGTGGAGGTGGATGGCGACGAGCGAGGCCAGAAGCGCGCCCATGGCCACGAGGGTGAGGGGAAACCTCTCGTAGTGCCAGAGGAAGACCCAGGCCGCATTGGCCAGGTTGGAGGCGAGGAACCAGGGGCGCACCCCGGCCAGTCTGGGGTCCTCCCTCACCGCGGGGCGGAGCTGGTAAACGGAGAACGCCAGGATCCCCACGTAAATCAGGCCCCACACCGCAAAGACGTACCCCGCCGGGACGAAGTACACCGCAAACCGGTCGGAGATCTCCCCGGTCTTAAGGCCGTTCAGGGGAAGGGCGTTGGCGGCGGCGTTTACCGCGACTGTCGCCAGGGCGCTGAGCAACGCGAGCCACGGGAGGAGCGCCTTCGGAGCCGCTTTCACCCTTTGCATTCTATGTTTCACGAAGAACGGGTTTGTACCCTAGGGCAAAGTCCCCACCCCAGGACGCCCCACGCCTGGGCTTTGGCCGTCACGGCAACGCCGCCCTAAGGGCCTTCGCGGTCTCCTCGGGCAGGGCGTCCACCACGAACGTCCCCGCCCCGAGCTCCGTCCCCGCCAGGAATTTGAGCTTGTCCCGGGTGCGCCTCGGGGGGTAGAACTCCACGTGGAAGTGAAAGGTGGCCTCCTCCCCCAAGGGCGCGGCGTGGAAGACCATGACGTAAGGGAAGGGCTCCCCAAAGAGGGCGTCGTACCGGGCCACCACCCGGCCCAAGAGCCTGGCGAAGGCCGCCATCTCCCCCTCGGAGAAGGTCCAGGGACCGGGGTGCCTTTCCACGGGGGCCACCCAGACCTCAAAGGGGTACCGGGCGAAGGGGGGGACGAAGGCGAGGAAGCCCTCCTCCTCGTCCACCACGTAGGGCCCAAGGTTCGGGAAAAGCTCAAGGAGCACGGGCCTTTCCCGGAAGGCCTGGCTTTCCCGCTCCAGGACGGGGGGCACGAAGGGGTAGGCGTAGATCTGGCCGTGGGGGTGGTGGAGGGTGACCCCCACCGCCTCCCCCCGGTTCTCAAAGGGCATGACGAAGCGCACCCCGGGAAGGGCGTAGAGGGCCTCGTACCGGTCCCGCCACGCCCAGGCCAAAAGGAGCCTTTCCTCCTCCGTGAGGGTGGCGAGGCTTCCCGTGTGGGCGGGGGTGTAGACCACCACCTCGCACCGCCCCAAGGCCTTCCCCGCGGGCACGGGAAGCCCCTCGGGAGGGGGAGGGGCTTCCTCCACGAAGGAGGGGAAGCGGTTTTCAAAGACGGCCACCTGAAAGGAGGGGAAGGGGATCTCCGTGGGGAAGCCCCCTTCCCGGCTCGGGCACAAGGGGCAGTGCTCCTTGGGGGGGAGGAAGGTGCGCCCCTGGCGGTGGGCGGCGTAGACCACCCACTCCCCCCGCAAGGGGTGGTAGCGGAGGTGGGGGGCGGGGCGGAAGGGCTCGGCGTCTTCGGGGAGAGGGGGGCCCTCGAGGGGCATTAGGCCGTAGAGGAAGAGCTCCCGGCCGTCCTTCTTCCGGTGGAGGCGCTTATAGAAGGGGGGCATAGTCCACCTCCTCCTCCCCTACCCTAAAGCGGTAGGGGCCGAGGCGCCGCACCGGGACCTCCCGGGCGAGGAAGGCCTCGAGGCGCCCCTTTTCCTCCGGGAGGAGCCACGAGGGCGGGTCGGAAGTGGCCTTGAAGCCGGTGAAGTGGGCCAAGGCCTCCTGAAGCCGCATCTCCTCGGGGGAAAGCAGGTTAAAGCGGGTGCGGAAATAGACCACATCGGGGTCCACATGGACGTTCTCCATGAGCCAGAGGCGGTGGAGGGTGGAGCGGAGGGCGTTCCTTAGGCCCGGCCCCGTGGGGTCCGCAAGCCAAAAGGAGCGCTCCTCGTTGTCCCAGTAGGGGGCCACGTCGGGGCCTACCCGGAGGCCGTCGGCGAGGCCCAGGGAGGCGAGGACGGGGGCCCCGCAGAAGAGGAGGTAGGCCTCCCCCGCCGCCTCCCGCAGGCGGGCCATGGCCCTCCGGTAGCGGGCCTCCCCCTCGGCCCCGGGAAGGGCGGCGGCGTAGAGGAAGTCCAGCTTCAGGTAGTCGTAGCCCCAGGCGAGGGCCTTACGCACGAGGTCCGCGGCCCACTCCACCACCTCCTCGTTCCCCGCGTCCAGGGCGTAGAGGGGCCTGCCCCAGTTGAAGCCCGCCCGCACGGGCCTCCCCTCCCCGTCCCTCAGCACCCAGTCGGGCCGCATTTGGAAGAGGGGGCTATCCGCCGTGACCAGGAAGGGGGCGAACCAAAGCCCCGGCCTCAGGCCCCTTTCCCGGATCCTCTCCGCGAGGAAGGCCATCCCCCGGGGGAAGCGGTCGTTGGGCTCCCAGTCCCCGAGGGCCCGCTGCCAGCCGTCGTCTATCTGGAAGACCTCAAAGGAGAAGGCCGCCACCTCGTCCAGAACCCGAAGAAGGAGGTCCTCGCCAATCCTCGTGTAGAAGCTGTACCAGGAGCACCACACCCTGGGGGGCCTCCCGGAAAGGCGCCTGGGGAGAAGCTGGGCGTAGGCGGCGAAGACCTCCTCCTCCGGGCCGTGGGCGAGGAACCAGGCCCCGCCCTCTCCGGCGTAGCGGCCGAGGAGGAGGTCCTCCCGGCCCAGGACCCTGGCCCCAAGGTCTAGGGCGCCGAGAAGGAGCGCCCTCCCGTCCGGCCCCCTAAGGGCCCCCACGCCGCTTCCCCACCACGCCCCGGCCTCCAGGAGGAAGGGGTCATCCGCCTGGGGGCGGCGCGCCTCGGGGAGGAGGGGCGTGGGGGCCTGAGCGGGGTCCACCCAGGCGGCGAGGCTCCAGCTCTGCCAGCCGTGGCGGAAGAACCCCTTGGCGGGGAAAGGGGGAAAGACCCGCACCTCCCTGCCCCAAAGGCGCACTCCCCCCGGGGCCTCCTCCAGGCCCTCCGCCCTGAGGAAAACCTCCGCTCCTCCTAGGTTCAGCCTCATCCTCCCTCCTTGCCGCCCAGGGTACCCCACCCGGCCTGGCCTCGAGGCCCCACGCGGGCACCCCTCTCCCCTATCCGGATGCGAAGCCTCTCCCAGGCCAAGCCGTCCATATCCCCAAGCTACCAAGGCCCTCAGGGCAGGCGCCGCGCCAGAACCCAGGGGAGGGCGGCCAGGGCCTCGAGGCGGGACATTCCCCACCCCTCAGGGATGGGCGGCAGGAAGAGGACCCCGCCGAGGCCGAGGCCCCAGGCGAGGGCGAAGGGAAGCGGCCTCACGCCCCGCCCTCGGGCAGGTACAACGCCCGCGCGCCCAGGGCCTCGGGCGGGTAGTCCTCCCCGAGGAGGAAGCGGCGGGCGTAAAGCCCGGCGAGCTCCCGGTAGCGGGGCCCGGCGGTGGCGCTCGCCTCGAGGAGGCCCGCCACCGCCGCAGCGTCCGCCAGGCGCCTCAGGGCCGTCTTGGCCGAGAACTGGGCGGCCTCGGGCTCGAGGGCGGCGAGGCGGTCCAGGGTCTTGCGGGCGGCCGCCAAGGCCCCCTCGGCCTCCTCGCCCCGTCCCTTCAGACGCGCCTCCAGCCAGGCGAGAAAGGGCCTATGGGCCCCCTTCTTCTGCATGGCCTCCAGGAGGTCCAGGGCCTGGATGTTGCTCGGCCCCTCCCAGATGGGGGTGATCAGGGACTCCCGGTGCCAGCGGGCCACGGCGTACTCCTCCAGGAAGCCCAGCCCCCCGAAGAGCTCCATGGCCAGGCGGGTGATCTCGGCGCTGTGCTCGGCGGTGCGGTTCTTCGCCAGGTGGGAGAGGAAGCGGGCCAGGTGGTAGGCCTCGCCGTAAGGGGGCCTCTCGTGCCAGGCCCGGTCAAAGGCCTCCACCGCCGCCAGGGCCAAGGCCAGCCCCCCCGCCTGGCGCACGGAGAGGTCCAGGAGGTCGTAGCGCACCAGGGGATGGTCCGCGAGGAACCTCCCGAAGCTCTGCCGCCGCCGCACCCGCTCCCGCGTCTCCAAGAGGGCCTTGGCGGCAATTCCCATGGCGGCGATGGCGTTGGCCAGGCGGGAGACGGTGAGGGTCTCCAGGGTGTAGTAGATCCCCTCCTCCGCCCGGCCGATGAGGTAGGCTTCGCTCCCCTCCAGCTCCACCTCCCCCGAGGGCACGGCCCGGGTACCGCTTTTCCGCTTGAGGCGGCGCACTCGGTAGTTCAGGCGCCCCTCGCGGTCCAGCCTGGGCAGGAGGAAGAGGGCCAGCCCCTTGGGGCCAGGGGGCGCCCCCTCGGGCCGCGCCGTCACCAGGGCCACATCGGCAAGCCCCGCCCCCGAGGCGAAGTACTTGTCCCCCCCGTAAAGGCGCCAGACCTCCCCTTCCCTGCGGGCCACGGTGCGGTTCGCCCCGAGGTCGCTTCCCCCCTGGATCTCCGTCATCCAGGTGGCCCCAAAGGCCTCCCCGTAGAGGACCCGCTCCTTCCAAGAGGCGAGCCCGGGGGCGTACTTGTGGATGGGGTAGGCCACCTGGTGGGTGATGGTGAGGATGCAGTAGAGCCCGCCGTCAGCCAAAAGGTAGCCCAGGGCGAAGTGGTGGTGCCAGCTCCCTCCCTCGTAGGGCGGGCGGACGATCGGGCGCAGGCGCTTGAGCACTTCCCGCTGGACGGGCGACAGGCGCACCCGGTCCACCCGGTTCCCGTCCAGGTCGTGCATGACGAGCTCGGGACCCGCGTCCTGGTCAATGTGGTAGGCGGCCTCGTAAACCTCCCGCCCCATGTAGGCGCCCCAGGCGAGGAGCTCCGCCTCCCTATCCCCCGCCCCGGGCCAGAAGTGGCGGAGGAGGTCCCTAAGCTCCGGGTCCGCCTCGTAGTGGTTCTTGCCGTAGGCGTACGAGATCCACTCCACTACCTCCTCCTGATGCAGGGGCATTATACAGGCCCCTCCCCCATTTGGGGGATGCGCCCCCTGCGAAAATCCCCAACCATGTAAGGAGGGAGGGAGAGCTTGCGGAAGGGTTTCAGCGTGATAGAGCTTCTGGTGGTCCTCGCCGTACTGGCCGTCATCTTCGCCATAGGGGCCTTCAACGCACGGCGCACGCTCCTAAGCCAGGAGCAGGCCGCCTTTTTGCGCTCCCTGCAAGGCTTGTTCTGGGAGGCGGCCACCGAGGCGGCAAGCAGAGGGGAAAACCTCGTCCTCCACTTCACGGGGCAACGCCTCGAGGTGAGGCGGACGGACGGTACGGCTCTCCGCGCCTTGGACCTCCCCCCGGGGGTTTCTCTAAGCCTAACGCCGGGCGTGGTCGCCCGGTTTACGCCTCCCGGCAAGGTGGCGGACCAGGACGGGAGAAACCTCCGCCAGCCCCTGAGCTTCACCGCGACGGTGGGGTCCAAGACCTACACCTATACGGTCTCCCTGATCGGGGAAACGGAGGTGGTGCCGTGAAGAAGGCCCTGGGGCTCACCCTGGTAGAGGTCCTCGTGGCCATCGCCGTCCTGAGCCTCGTCCTGGTCGCCATGAACGCCGTCCTGCTCTCCAGCATCCGCCAGACCGCCATCAGCGGCTCCCGCACCCAGGCCGTCCAAATCCTGAACTACCTGGGCCGACGAGTCGTGGGCGGCGAAACGGCCCTCCTTCCCCCTTCGGGGACGGCCAAAGTCTACGACTACGGATCCCTGGGCACCGCCTTCCCCGACCTGCCCCGCGAGGTCCGCTTCGCCGACCCCGCCCTCTACAAGGTGGAGATCGCCAACCGGGGCAGCCCCAGCTGGGCTTCGGGGCTCGGCGTGGCCGTAAACGCCTACCGGATCCGGGTGTGCTGGCGCCAAGCGGGCGAGGAGCGGTGCACCGAGGCTTACACCCTAAGCGCCCCTCCAGGCGGCGCGGGGCCAGCCGCTCCTCCGCTTCCGGGGATCAACTGAGGAGGTGAAGTGTGTCCGAGCGCCGAGGCTTTACCCTTGTAGAGCTCCTCCTGGCCCTCGCCATCCTCGCCACGCTGTTGGCCGTGGCCTACGGGGGCGTGATCCAGTTCATGCAAAGCCGCTCCGACCTGGATGCCGCCATCAACGCCCAGGCCAAGCTCCGGAGGATCGTGGAGGTGTTCACCCAGGACCTGCGTAGCGCCGTCTTCGGGGGGCTAAGCGCCACGCCTTATCCTAGCGGCAACGCGAGCATCTCCTTCGCCTTGATCGAAGGGGGGGCAGGATACCCTGTCCTGCCCCACGACAGCGGGAACAACCAGAGCTTCAAGCGGGCGGCCGAGGCGAAGATCGTCGTCCTGGCGGGAGCCCTTTCGGGTGTGGGCATAGCCCGGGGAGACGAGGTCCTCATGGTGAACAACCTGGGCGACGGGGTGATCCTCCCCGTGACGGGCGTCAACCCCGTGGGGGGCGAACCGAACCGCTGGCATGTGGTCCACGCCGGATGCGGCAACACCATCGACTACACCCCGAACACCCTGCTCTTCCGCGTGCGCACGTTGGGCTTCCGCTTTGACCCGACGACACGTCGGCTCGTCTACAGGGAGGGCGGCGGGGAAGAGGTGCCCGTGGCCTTTGACATGGAGCGGTTTGAGATCCACTACGTCTACGAAGGCGCTTTCGGGGACACGGTGACCGACCCTCCCGGAGGTGCCTTCACGCCAGCCTACGACTTCGCCCGCCCCACGGGGGCCCCCCCGTACCAGGTCACGGAGGTGGCCACCGGAAAGGTCTACACCCTTAGGCGCCTCTCCCTGGTTCTGGAAGCCCGCTTCCCCTCCCGTGGGCGCCCGGTGAGCCGTACCTACACGGCCCAGGTGGAGCTTGCCGCCAACACCCAGTACCAGGCCAAGCGCATCGTCCCATGCGAATGAATAAGGAGGTGCCCGCATGAGAAACAAAGGCATCGCCATCGTCCTAGCCCTCGCCACGGTCCTTGTGGTCTCGGGCATCGGGACCCTGATCTTCACCCGGACCATCCGCGAGATCCGCCACGGCGCTCAGGACCAGGGCATCGTCCAGACCCTTATGCTCGCCCGAGGGGCCGCCAACCTCGGAGGCTCCTTCCTCGCCACCCGGGGCCGGGAAAGGCTGGAAAGGATCGTGCAACAAACCGCGAGCTCCACGGACAGGTGGGCCTACGGCAGCAAGGCCAGCAACACCGGGACCGAGGCGCCGGACCCTGCCCTCGTGGCCCAAGCGCTGGCGAACGTGGCGGACCGCTTCCAGTCCGACCTTGACGGCTTCCTTTGCGGAAAGAACTTCGCCCCGGACGGCCTGCCCGCCGAGGTGCGGGTCCGGGTCTACGTCACTACGAGCGCCTGCGGCGAACCCCTTCCCCCAAAGACCCACCTCCCCCCGGGGCGCTTCGTGGAGGGGGCGCCCCGGACAGGGACGGGAAGCGGGGCCAGCCAGACCTACGCCCTCCCCTTCGTCATGGTGGCCGAGGCCTCCCTGGGCCAGGCCCGCCGCAACATCGTGCTCCAGGGGGAGTACCGCTTCACCATCGGACGCTCCAGCTTCGCCCGGTACGCCCTGTTCACCAACGTGCACACCCTTCCCAACGGGACCGAGGCCGAGGTCTGGTTTACCGACCGCACCCTCTTTGACGGCCCCGTGCACACCAACGGCCACTTCCGCTTCTACCGCAGGCCCTGGTTCGGAGGAGAGGTGACCAGCGCAGGGTGCACCAACCCCGGCACAGCCTCTTGCCAGGGCCAGACCGTGCCCGGGGCCTATTTCTACGGAGAGGGGTTCGTCCGCGACCGCAACATGCAGCCGAGCGCCGCCCGGCCCTCCTACAGGAACCGCTACGGCACCCACGCCCCCGAGTTCACCGCCGGGGTGGACTGGAACGCGAGCTTCATCCCCCTGCCCCCGAACAGCCAGGACCAGAGGACCGCCGCCCAAGAAAGTGGGCTCTACTTCAGCGACGACATCCGCTCCCTCAAGCTCTACCGCAAATGCCTCCTCGGGGAAACCGAAGTGGCTTGCTCGGAGCCGCTAGATCCGGGCGTTCGCAAGCTTCAGTACATAGAAGTCACCTACTGCGCACAGAAAAATCGGAGAGGACAATGCACGCAGGACACCACCGAGGTCTACCGTTACGGTCCGGACGGACTCCTCTACCAGGAGAACAACAGGGGCCTGTTCGTCCCCGTGCTCCGGAACGGAGCCCCCGTGCGCTTTAACGGGGTGATTTACACGGACGGCGAGGTCCGAAGCCTCTCCGGTCCCGAAAGGAGCCGGGACACAGACCCCGCCACCGCCCCCCCCGCCCTCGCCGAGTTCGCCCAGATCACCGTGGCGGCCCAAGGGGATATCCGCATCACCGGGGACCTCAAGTACGAAAAGCCCCCCTGCACGGGCGTGCCCACCCGGGAACCCGACAGCACCGTGACCCCTGCCGTCTGCGACAACCTCGGCGTCCAGAACGTGCTCGGCGTGTACAGCCAGGGGGGGAGCGTGTGGATCGCCCGCGAGGCCCCCCGGGACATCCACATCCACGGGACGCTCATGAGCTCCTGGGGCGTTGTGGGCGTGGAGGACTACGACAGCATTCCGGAGAAGGGGAGCGTCTACCTTCTGGGCGGCATCATCGAGTACTACTACGGCGCCTTTGGCACCTTTGACCCCGCGACGGGCCGGAACAGGACGGGCTACGGCCGGGCCTTCACCTACGACCGCCGCTTCCTCCAGGGCCTGGCTCCTCCCTTCTTCCCCACCACGGGGCAGGACCGGGTGACGAGCGTGAGCGTCTTCAGCTACGGGCAGCGGGAGCAGGTGTACTAAAGCTTCGCAAAGCGAGGCCCAGGGGCGAGGGCGTCCTTCCCTCGCCTCTGGGCTTTAGAACGCAGCAAGGCCTCTACACCCTTCCCGCTCCCAGCTCCTCACGCCAGAGGCGCAAGAAGCACTCAACCAACCGGGGGTCAAGCTTCCTCCCCGCAGCCGCCTGAAGCTCCTTGGCGGCGATCTCTGGCGGCAAAGCCGGTTGGGCTTGCCTTGCAAAGGTCAGGAGGACGGGTGTATATCTCTCTCCTGATGGGCAAGCGAGGCTTCCTTCGCAGGGAGGCAAGCCCCAAGGAGGTCCTGGAACACTGCCTGCGCCTGGCCCGGGAGGTGGCCCCTCCCACCCCCAAAGGCAAGCGGGGCCGCCCCTGGCGCTACAGCCACGCCCTTTACCTGGCCCTCCTTCTCTTCCGCGCCTTCTTCCACCTCACCTACCGCGAGACGGAGGCCTCACTCCAGGACCTGATGGAAGGCCCCTTCCCTTCCCACCAGTCCCTGGCCCGCTACGCCCTCAAGCACCTGGACCCCAAACTCCTTGAGGCCCTCCTGGAGAGGCTTTCCCGGGAACTGGAGGCCCATCTCGCCCCGGAGTCCTCGCCGGAAGGCGAAGCGGCTTCGGACGAGGCGCCGGCACACCTGGCGGCGCTTTCCCCCCCTCTACCTCATGGACACCACGGGGCTGGCCTACCGGAGCAAGGACCGGCTTCTCCGCTTTCGTCGGGGGAAGGAGGTGCGGCGGGTGCGGGGGCACGCGCGGCTTCTGGCCCTGATGCGGTGGGATAGGGAGAGGCGGCTCTTGTGGCCCTGGGGTGGAGTGGTGGGGGAGGGCTACGCCCCGGACCCCCGGCTTGGGGGGGAGGTGCTGAGGCGGTTTCCTCCTTCCCGAGGGTGGCTTTTGGCGGACGCGGGGTTTGACGGGAAGGAGGTGTGGGGGGTTTTGGGGGAGGCGGGGGTGCGGCCGGTGATCCGGCTTCGGGGCGGGGGCGAGGCCAGGGAGGAGGCGCGGGTGCGGGCGCGGGAGGGGTGGGACCCCGAGGTGTACCGGTTTCGCGGGGTGGTGGAGGGGGTGTTTGGGGGGATGAAGACGCGGCTGGGTGGGGGGTACCTTTGGGAGCGGAAGCCTTGGACGGCCATGGCGCGGGCGCTTTTGGAGCTCATCGCCTACGGCCTTAGGGTTCTTCTCTCCCTTCTCCCGCCCCCTCCGGGGTACAAGGCAATTTACTAGGCAAGCCCAAGCCGGTTTATAAGGCCTCCGAGAGATGAGGGCGTCCCAAACGTCCACCACGGCGAATACCCTGGCCTCCAAGGGGATCGCCTCCCCCCTCAGACCCCTGGGATAACCTGTCCCGTCCCAGTGCTCGTGGTGATGCAGAACCACGTTGAGCGCTGTAGGCGAGAGGAAAGGAATGGAGGAGAGCACCTCGTAACCCGCCTCCGGGTGGGTTTTGACTTGAATCCACTCCTGGGTTAACAAGGGACCATTCTTTTGCAGGAGCTCTTGGGGAAGGAAGAGCTTCCCCAAGTCATGGAGATAAGCACCCACATACAGACCGTGCAAGTCCTTAACACCTACCACCCGCCCCAAGGCCACGGCCAAACGGCTTACCCGCTCCATGTGGCCGTGGGTTTCGCAGTCCAAGACCTCCATAACGCGGGCAAAAGCCCTCAGAAGCCCCTCCGCATACCAGGTCTTACGAAGCCAGCTTTCCAACCCCTCCTTGGCGATCTGGAGTAAGAGCAACGTCTCGGGGCTGAAGTGGGGAAAGCGGTTCAGGCTCGCCAGGATCAAGGCCCCGAACACACTGGCGGGCGTTCCCTCCCCTAGAAAGAACACGGCCACCGTCTGCACCCCAAGCCGCCCTAAGGCGGGAAAATAGGGAAGAATCGCTTGAACGTCTTGCACCACCCAGGGAATGTCAGGGGCTTCTGCCCTTCCAACCGCCTCCTTCAGAAGCTCCTGAAGAGAACGCACCTCCTCGTGCGAGAGCGCAAAGTCCAAAGCACCAACCCGGACCCAGGGGACAAAGGTGCCTTCGTGCCTCCTTAAGACCATGGCCAAGTCCCACCCGCCGAAGCGGAGGAGCGCCTCGAGGACTTGAGCCACAACCTCCTCGGGAAGCCGCCCATTGCGTAGCTGGCGACCTACCGCAAGCAAGGTCTCTAAACTTTGCCTCATCCGAAACTCCCGGTCTAGTAGATCCACCCAGAGCTTTATCAGCTCCCGACGTTCTTGGCTAAGGACGAAAGTCCCCTCTAAAGCGAGGGCATGGTTTTTTCCCAAGGCAACAAAACCCGCCCGAGAGGTTCCATCCGGGGAAAAACCCAGCGGGCCGGGAGGATTTGTAGGTCCCTCCCGAAGCTCCCAGTCCCGGGGCAGGTAGAGCCCTCTGGCTCCCGCAGCGCTGCCTCCCGCGGCCACCACGCGGTAGCGCTCTCCCTCTTTTTGGAGAACGTAGACCCCCTCCACACCGAGAAGGCTTAAAGCTTTACTCACCACGTCCCACAAAAAACTCTCAAGACTGGACTTACGCGGCCTCCACCTGCACCGGTAACAGAGGGCTCAAATCCAGGCTCAGCTTACCCGCGATGAGTCTCCGTCGGCACTGATAAAAGCTCAACCCCAGCCCCTCCCGTTGCCGCTCTATCAGCCCGTAGGCCACCAGCCCTAGCGCCAAGTGCGCCAGTAGCTTCCCCCTCCGCCAGTGCCGGTGCCCCGTCCACCCAAGCTCCTGCTGCAGCCCCCGGAATATTTCCTCAATGGCCTGCCGCATCCGGTAAACCTCCCGCATCCCCGAGTCCCACCACCCCTCCCGGTCCGTCCCGTAAAACTTCCCCCCACGCTTGAGCACCCCCACGGCAAAGGTCAGGCCCCTAAGCCTCCCCGTCTTCACCCAACGGGTACCCCCATGCCGCCGCAACTGGACACCGTCCAGCACACGGTTAGACCTGAGCCTCGTCACAAAAGGCCAGCCGTGCACATGGAGCCACTCCAGGACCTGCCGCGCCGCGTACCAGGCGTCAAAGAGCACCCCCTCCGGACGAAAGCCCGCCTCCTTGGCCCACTCCAGCAGGGCCAGGGCCAGGTCCAGCTTGCTCTCCTCTTCCCCGAAGTAGGGCAGGAAGGCCAGGGGAATCCGCCGCTTCCCGTCCGTCCAGGCCAGGACCACCAGGGAAAGCCCGTAGGCCCAGCCCCCTGTGGCGGTGTCCCGCATCTTCCTTAGGCCTAGCCTGCCCGAACGGTAGCGCTGGATGAAGACGTCATCAAGGATGAGGTAGCCCCGGTCCAGGCCGCCGAGGTCTCGGCAGAGCTTCAGGGAGAGCTCAAAGAAGAAGGCCAGGGGTTGGCCCAGGGCGCGGTAGAGGGTGTCGTGGGCGAAGCCTTGGCCCTCGGCCATGGCCAGGGCGGAGGTATTGATGGGGCTTTGGGCTAAAGCTTCTAGAGCGCGCAGAACGGGCCGTGGTATCCTCTTCATCGGGCCTCCCTAGTCACCGGGGGCCCATTTTATCGGGGATCTTCAGCACCGCGTAAGTCCAGTCAAGAGAGACCTCGTTTTCCCAGGAGGCGTAGCACCCCATCTTCCTCCGCCATTTTATTGGGTTCACACCGTAACCCCATATCCAAACTCCAGGCCCTTGTTTTCCCAAACCACCCCCCACAGGTCGGGACGGAGCTCCCCTGCTTTCCCCAAGTCTTCCGATACCTCCAAAGCACAGGTAGGCCAGAAACCCCCGCTGCTTCTTCTCTCCTCCACGGACCTCCCCAAGTCTTCCGATAGCAGGGCGAGGACCCCTAGGGTCTCCCTGTAGGTGATTCTCCGGTGGGCCCACGGGGGCGCCGACCGGGCCAAGCTCTCCGCCCCCGAGCTCTACCTGGAGGCCCACCTGGGCCGCCTGGTGATCCTGGAGAGGTCCACCGCATGCCCGGGCTTTTCCCCCTCCTCCGCAGCCTCGTGGACCGCGCCCGCAGGCGGGGCTTGCGAAGCGGCCTTTACCTCCTCCTGGGCTCCCTCGCCCCCGAGGTGAGCCGCCAGGCGGGGGAGAGCCTGGCGGGGCGGGCGAGCTACCTGGAGCTTGCCCCCTTTGACCTCCTGGAGGTGGGCCGGGAGGCCGAGCCCGTCCTGTGGCTCCGGGGGGGCTTTCCCGAGAGCTTCCTGGCCTTGGGGGATGAGGAGAGCTTTCGCTGGCGTCTGGACTTCCTCCGGTCCTACGTGGAGCGGGAGATCCCTCTCCTGGGAGGGCGGCTTCCCGCGGAGGGGCTCCGCCGCTTCCTCACCATGCTGGCCCACCTTCAGGGGGAGCTCCTGAACACCTCCGCCCTGGCCAGGAACCTTGGCCTGGACGGGCGCACGGTGAACCGCTACCTGGACTTCCTGGTGGACCTCTACCTGCTAAGGCGCCTGCCTCCCCTGGAGGCCAACGTGGGGAAGCGCCTGGTGAAAAGCCCCAAGCTCTACCTGCGGGACAGCGGCCTGGTCCACGCCCTCCTGGGGCTCCGCACTTTGGAGGACCTCCTCGCCCACCCCGTGGTGGGGAGGAGCTACGAGGGCTTCGTGGTGGAGAACCTCCTCCGGGTGCTTCCCGAGGGGGGCGAGGCCTACTTCTACCGCACCCGGGCCGGGGCGGAGGTGGACCTGGTCCTCCTCCTGCCCGGGGGGAGGCTCTGGGCCGTGGAGGTGAAGCGGGGCCTTGATCCCCGGCCTTCCCGGGGGTTCCACGAGGCGCTGAAGGACCTCAAGCCCCAGGAGGCCTTCGTGATTTACCCGGGAGGGGAGACCTTCCCCGTGGGGGAGGGAGTCTTCGCCGCTCCCCTCGGGGCGGTGATGGAGCGGCTCTGGAGGGGGTAAGCGCCCGCCCTCGGGTTTCGCGGCCCGGGTCTATCCGGCCACGCTAACCTTGCTGGTAAGGCGGCTAGCCAGGGCCGCGTAGCTGGCCGTGGAGGAGTTTTACGACAGCCTCTAGGAAACCCGCCCGGTAACCGCCTCCCCCTGGGGCGGAGCTTCCCAGGGCGCCCAGAAAGTTCACCGGGACTTCGCAGTCACAAGGCTCCAGGTCGTCCGAATTCGCCGTCACCTGCTTTTCTCGCAACGCACGCACCAGCCTCGCCCATGCGCTTCCCCGCCTAAAGCGATCCCCCAACACCCAGGACAAACTGGGCACCGGAAAGGGTGGCAGAGGTGAAGGAAAGACCAGAGAGAGAAGTCTCCTGGAAAGCGAGCGCTGCGCCCAAGGCGTCTAGCCCTCCCTTCTTCACCGCGAGGATGGAGAAAAAGACCTCTCCGCTCGCGGCGTAGCGCACCCCGAGAGAGGATGGCAGCTCGGGCAAGGTAAGGGAGGATGTGGTCCAGAAGGCGAGTGGCAAGGCCTCCGTTCCCCGGTACAGAAGGCCGCGCACGTGGACCTCATACCCTTGGGCTCCCGGGTGCCGCAACTCCCAGGTTCGGCCGTCGGGCGAAACCTGGAGCTGGCCAGGTCCCCAGGCAGAGGGGAGGCCCGGGGCCCAGTCAAGGCCACGGGTGTCTTCGAGGAGAAGGACCTGCGAAGAACACTCCTGGGCGCAAAGGCTGCCCGAGCGGAGATAGGACAGGTGAACATTGAGCCGGCCTAAGTAAACGCCCCCATGCCCCGGGAAAACCGCGTACCGCCCCGCCTCCGTACCCTGAATGGTGGCATAAGAGGGGGTGGCCGCGAAGTAGCGGCGCATGCCGTCCTTAAAGTAGAGAACATCCACGGTGCCGTAGGCCCCTTCGGGTAGGGCCACGATCCAGGTCCGGGTCTCCACCGTGTCGTGGTCGGAAAGGTTCGCAGTCACGCCCCTTCCCTCCTCCACCACCAGATCAAAGACCTTGCCCCCGAGGAGGGTGGCTCCGCTTCCGTAGCCCCTGTAGACGAGGAGGGAGGCCTTCTGGGGCCCTGGAGGAAGGCCGAGGTAGGCCACCTGCGTTCCACCCGGCGCCACCTGGCCCCCGGAGGAGCCGTCAAAGGTGAAGGCGTCGTCGGACGCCAAAGGCACACCGCCGAGGATGGAGGGAAAGCTCACGGCAATGGGGGTGCTCACCTGACCCTTGTAGGGGTGGGGAAGGGAGCAGGGAAGCCGCAGGTTTTGAACCTCTCCAGCCGTGGCCCTGAGGAAGAGGACCTGGCCCTCCGGGTAGTGGTAGGAAGGACCACAAGAGGCGACGACCTCAAAGGGCAGGGAGGGGTCTTCGGAGCGAAGGCGCAGGGTCTTGCTTTCCAGCGAAGCGGCCCGCCATACATCCCCTGAAAAGCGGTAGTGCACCTCCTCTAGGACGCCTTCGGCATCGTAGAACTCGATCTGGACCTCTTCAGTAAAGGACTTGGGGGGAATCTCCCCAATGCCGCAACCCCCTAGAGCTACCGATAGGGCCGCAAAGACAAAAGCACCCCTACCGTCCATCTTTGCCTCCTTCACCTCACCTGGCAGATGCCGAGGTAGCCCTTCTTGCCAACTTCATCGCTTGCAGACTCCCCAGAGCGCTTGAACTGCGGGAAGCAGGCCCCAAAGAGGCTTCCCGAGAAACAAACGAGAGGGCGTTACCTCGGCCCCTCTAGGACCCGCTCCAGCTCCGCGAGGAGCTCTTCCACCCTCGCCCGCCGCTCAGGGGGGAGGGCCTCGAGGTCCAGCCGGGCCAGCTTCGCCGCCACCTCCTTAGGCCAAGGCCTGGGAGCCTTCTCCTTCCGCAAGACCCCCCGTACCCGGGCCTTCAGCTCCCGCAGGGAGAGGCCCGCCTTCACCTCCTCCAAGAGGGCCTTCCGCAAGGACGCGTCCTTCACCTTCTTGAGCTCCAGGGCGGCGGTGTAGGGGATCGCCCCCTCCTCCAGGGCCGCCTTCAGGTCCTCGGGGAGGGAAAGGAGGGGGAGGCGGTGCTGCACAAAGGACTCCCAGGACATGCGGCCGAGGGCCTTGAAGAGCTCTTCCACCCGCTGGGCCTCAGCAGTAGGAACAACGTTGTCCCTAACTCGTCCCTCCTTTGCGTTTTTCATCTTGCGGAGGAGCCCCACCACCTCTTCCACCGACTTCCCCAAGTCTTCCGATAGCAGGGCGAGGACCCCTAGGGTCTCCTCGTAGGGGTTCAGGTCCTCCCGCTGGAGGTTCTCCACGAGGGCAAGGAGCCTCGCCTCCTTCTCGGAGAGGTCCAGGACCCGCGCCGGAACCTCCTTAAGGCCGGCCATCGCCGCCGCCCGGAGGCGCCTCTCCCCAGCCACCACCTCGTAGGCCTCCCCGACCCGCCGCACCAGGAGGGGCTGGAGGATCCCCTTCTCCCGGATGCTCTCGGCGAGGGCCTCGAGGTTCTCAAAGCGCCGCCTCGGCTGCCCCCGCACCCGAAGGAGGTCCAGGGGAAGGCGAAGCACCTCCGGAGCCTCCTTCCCCAAGGCCTTCTTGCCCTTGAGGATCGCCGTGCCCAGAACCTCGTCCAGCCGGCTCATTCCGCCACCTCCTCCAGGACCCCTTCCCGCGCGGCGTCCTGGGCCACCACGCGCTGCAGGAACTCCTCCGTCAGCCGCTCCACCTCCTCCCGGGCCTGCCGGTCCCCCACGAGCTGAAGGGGAACGGCCCGCTCCGTGGCCCTCCTGTGAGGCCCCGGGCGGTAGGCGATGGGGGAGGCCACGGGGGCGAGGTCCTCGAGGCCCGCGATCTTCTCCAGCACCCGGTTGTCCCCCAGGGTCCTGGCGTCAAACTTGGTGGGGATGAAGAGGCGCACGAAGGACCGGGGGACCCTGGGATCCACCTGCTCCAGGGCCTCTCGGTACTCCTGGGCCGCCTCCATCACCCCCACCAGGGCCTCCACGCCCTTCACGCTGGTCTCCACGGGGACGAGGAGCCCGTCCCCCGCCAGGGCCCCAAGGGCCGCCAGGTGCCCCAGGGAGGGGAGGGAGTCAATAAGGACGAAGTCGTAGCCCTCCGTCTTCCGCAGGGCCGTGCGCAGGAGCAGGGTAGAGAGGGGGCGCTGCATGAGGCGCACCTCCACCCGGGCGAGGTCCAGGCTCGCGGGGATGAGGTCCAGGCCCCACTCGGAAAGGCGCCTCGGCGTGGGCAGCTGGCCCGTGTCCACCAGGTGAAGGAGGGTCTCCTCCGGGGCGACCTCCCGCACCCCGAGCCAGGAGGTGAGGTTCGCCTGGGGATCCGTGTCCACCAAAAGGACGCGGAAGCCGCGGCGCGCCAGCTCAAAGCCGAGGTCGCGGGCGAGGGAGGTCTTGCCCGCCCCGCCGGCGTGGGTGAAGAAGGTGTAGACGCGGCGGAGCCGCCCGCCCTCCCGTTCCCGCACGTACCAGTAGCGGCCGAGGCGAACACCCTCCAGCTTGCCCTCGAGGATCATCTGCCGCACCCGTTCCCGCGTCACCCCGAGCCTCCGGGCCATCTCGCTCACGGGAACCAGCTCGCCCTGCTTCATGGGCCTAGACTATCCCAAGATTTGGCGTTTGCCAAGTATCCCCCACGTCACCCCGGCCCCCCGGCGGAGCCGGTAACTTGTATCAGTTCCGTTTTGCTGATGAAATCATCAAATATACCTACAACCCTTTAACTTAACTGATTGACTAATAATGATCAACAACAGCACAGAGGCGGGACGCGATGGGGAAGGGCTTTCCGGCCGCAAAACGCCCCAAGTCTTCCGAGTCCCCGCCGCCTTTCTCCCCAAGTCTTCCGATACTTTCTCCCCAAGTCTTCCGATAGGGGAGGGGGCCAACACCCCAAGTCTTCCGATACCTTTTCCCCAAGTCTTCCGATATCCCGCACCCCCCGACGCCCCAAGTCTTCCGATACTTTCTCCCCAAGTCTTCCGATAGGGGAGGGGGCCAACACCCCAAGTCTTCCGATACCGCCCGCCTCCGAAGAAAACCACTTGTGGAGGGCGAAACCTGGCGCTTCCCCTTCCCGCCTCCCCAAGTCTTCCGATAGGCCTCACCCCTCAGCCGGGGAGCATCTTGCGGAAGCGTTCCAGCCAACCTTCCAGCCGGTCCTGGGCCAAAGCCTCCTTCAGCTCCTCTACCACCTGTCTGGGCTCGAGGGCACCGGACTCCATGAGGCGGCTCAGGTCCTCCAGCTCCCCCACGGAGATGCGGGAGCGGAGGACGAGCTGGGCCACCTGGAGGGCCCGGCGGATCTGGGCCTCCCGGGGCATCTCCGCCCACTCCCTGGCGGCCTCCTCTTCCAGCTTCCGGGCCTCCGCCTCCTCCTGGGCCGCTTGCCGCTTGGCCGGGCGCCTCGTCCGGGTGGGGCGCTCGTACTTCCCGGTCTCGTCCCGGATCACGTCCACCAGGAGGCCCAGGCGGTTCTTGGGCCGGTAGCCCGCCTCGAGGATGGCCCGGTAGCGCTCCAGCCGCTCCTTGATGTGCCCCAGGGAGTAGCGCCGCGCCAGGGAGTAGGCGGAGGTGAAAGAGAGCCCCTCGGCCATGAGGAGGTTCACCGCCTCGGCGTCGGGGATCCCGCCCGCCTCCTCGCCGAAGACGTAGACGATGGTCTGGTTCTTCCCCCGGCCCACGTACTCCACGGAGCGGAGGTAGCGGCGCTCTATGAGTTCCCTGTGGGCGGGCTCGAGGGTGCGGCGCACCTTGTCGGGCCGCTTGTGGACGATCTTGCAGGCGGCGGCCCACTCCATGAGGCCCACCTCCAGCCGGGCCAGGGGCTCCTCCCGCTCGGGGGAGAGGCGCTGGGCGTCCAGGAGGCGGTAGAGGGCCCGGCTCAAGGGGCGCTTGAGGCTCGCCATGAACTCGATGTCTATGGGCTTGGTGTAGCGGTTCTGCAGGGAGCGGACGATCTCCTTGGCCAGGGTGATGCGGATGACGCTGGAGCGGTCCAGGCTCCCTTCCTTGCCGCTCGTGAACTCCAGCTTGTCAATATAGCGGAAGGAGACGCTCTGCCAGCGTCCGTCGGCCCGCCAGGCCTCGGAGAGGACGTAGGTGGCGGTGGTGAGGCGGAGGAGGCTCTCTTTTAGGGCCCGGTAGTAGTACCCCGAGGTGTCGAAGCCCATGAGCTTGAGGATCTGGTAGGCCGTGGTGGTGAAGGTGCCGTCGGGGGGGCTTCCCGCGTTGAGGTAGAGGGCGATGAGGGCCAGGGAGACCTCGTTGTCCAGGCCGTGGGGCACGCCCCCCACGTTCGGGTTGGCGTAGCAGGCGAGCTTTACCGGTTTGCCCAGGACCTCAAACTCCTCCTCCCAGGAGGCGTACCCCTCGGGGATCCTTTCCTGGATGGAGATGAGGCCGAGCCGGGCCACGTTGGCCTCGTCAAAGTGCCGGGGCTCCTTGGCGAGCTCCAGCTCGAAGAGGGGCGGGGTGGCGTCCTGCTTGCGCTTGCGGGCCATCTGCAGGCCATTTTACCCGGCAAAAGCCGGGGCGCCCTCTCGGTTCGGGGGCGCCCGGAAGGGGAGGGCTTAGTCAAACTTGTTCTGCTGCAAGAAGCTCGCCGTCTTCTGCACGGAGGGGATGGCCCCGGCCACCTTGCGGAGGTTGGCCCTCGTCCCCTTGTACCAGGGGATGGTGGTCTTGGGGTCGGTGTAGCCGGAGACCAGGGAGTTGGAGGTGCCCCGCCAGTGGTACATCACCAGGAAGAGGGTGCCCGGCTTCACCGCGTCCGTGACGTAGACGAGGAAGGTGCCGTTTCCCTCCTCGTTGTAGACCTCCACTAGGTCCCCGGACTTAAGGCCGAGGCGCTTGGCGTCCTCGGGGTTCGCCTCCACGTAGGGGAGGGGAAGGGCCAGGGCCTTTTCGGGAAGGTGGCGGTCGGTGCCCATGGTGGCCGCTTGGGCCGGGGACGGGGTTCCGCTCCCCGACCCCGGCTGGGTGTGGGGCGCGGTGGAGGTTCTGCGCGGCGCCGGGGCCTTTTCCGGCCTCCTCTTCTACCCCTGGACCCGGCCCCGCTGGGCGGAGCGGGCGATCAAGGACGTCCTTCCCGCCTACGAGGCGGTTTTCCGCCGGGCCTTCTCCCCCTAGTGCCAGAGGAGGAGGAGGCCGAGGAGAAAAAAGCCGATCCCGGGCCAGGGGTGAGGCCGCTTGATCAGGGCGTGGAGAAGGGCCACGCCGAAGAGGGCGAGGAGGGGATGGGGGAGGACCTTCCCCGCAAAGGCCAGGTAGAGGAGGCCAAGGAGGGCGTTGAGGTCATAGAGGCCGAGGAGGGCCCGGGCGAAGCGCGGCACCTTCCGCTTCACGAGGAGGTAGACGCCGGCGAGGAAGGCGAGGGCCACGAGGGCGAACCCCAAAAGCCGATGCAAGGCGGGCACCCCGAGGAGGGCCGTGGGGAGGCCCTGGAGGGTGTAGCCCAGGGCGGCGGACAGGACCACGAGGAGGCCGAAGCCCATCTGGGTCCAGCCCACGACCCGGGCGGGCACCGGGGGACGGAAAAGGGTGAGGCTCCCGTAGAGGGCGAGGAGGAGGAGGGCGAGGAAGACGGGGTAGGGGAGGAGGCGGCCTTGGGCGAGGAGGAAGGCTAGGAGGGCGCTCCCCCAGAGGGCGAGAAGGGCGGGGTGGCGCTTGGGCTTAAGGCCCCGCGCCCGAAGGACCTGGGTGCGGGCGTAGTAGAGGGCGGCCACGTCCCGCAGGGCCAGGGCAAGGAAGCTCCCCAGGGCCACCTCCTGGGGAAGCCCTCCGGCGAGGACCCCGGCGGGCGCGAAGGCGGCCATGAAGAGGGCGGCCCCGATCTCGGGGAAGAGCTCCCGGGCGCGGTTTTGGGCGTCGGCCCAGGCCATGTAGGCCCCCAAGGGCAGGGCGAGGAGGAGGGGCAGGAGGAAGGGCCCCCGGGCGGTGAAGGCGGCGAGGAGGAACCCAAGGAGGGCCAGGACCAGGTAGACCCCCGCCACCTTCAGGGCGAGGTCCGTCCTGGGGTAGCGCTTGCCCCGCCTGAGGTCCTGGTAGAGGAGCTTCAGGGGGTGCCGGGCGAGGAAGCCGAGGAGGCCGAGAAGGAAAAGCCCCAGGGTGGGGAGGCCGGGGGAGAGGAGGAGGCCTAAGAGGAGGGGCTCGAGGGTGAACCCCCAGCCCCCGTGCTCCGTGGGCAGGGCCACCGACTTGAGGGGGACGCTTGCCGTGCGCATGCCTTGCTCCAGGGTAGGGGAGGGGGCCCGGGACGGAAGTCCCTTAGGCCCAGAGCACCTCCAGCATCAGGAGGGCGAAGAGGGCCCCCGCCAGGAAGGAGACCCCGGCGAAGAAGCCCCAGACGCCGGGCCCTGGGTTTGGGCTCCAGGACGTGGCCAAGGGCCGCCCCTAGGCCGGGGCGTGGTCAGGGCAGGCGAGGCGGAGGTCTAGGGGCGCCAGGGGGATCTGGAGGAGGGCGCAAAAAAAGCCTTCTTCCCGCCGCAGGTGGCGGCAGGTGAGGCAGAGGCCCGTCTCCGCCATCACCCCCTGGCGCACCAGGGCGGCGAGGAGGTGCAAGAGGCCGAGGAGGAGGCCTTCGGGGTCTTCCACCTCCCCGAGGGCCTGGCTCAGAGGGGCGGCGTAGCCCTTCAGGGCCTGGGCCAGGGCCTGGCCCTCCTTCGTGGGCTTAAGGCGCCAGCGCCGCCTGTCCTTCTCGTCCTTCTCCCTTCGGAGGAGCCCTTTGCGCTCCAGGGCGGCCAGGGCCTCGCTCACCGTGGCCGGGGTGAGGGCGAAGAGGGCGGCCAGGTCCACCACCCCTTGGGGCCTTTCCGCCAGGTGGAGGAGGAGGTGCGCCTGGGTAGCGGTGAGGCCCAGGCGGTGGGCTTCCCGGGTGAGGAGGGCCCTTTCCGCCTGGGCCAGGCGTTCCAAGAGGGCGAGGAGCTTCTCCTCCACCCCTATAGCTTAGGGCCGGAAGGCGCTGAAGACGTAGTCGGTGTTGGCCGCCCCCTGGTGGCAGGCGTGGCAGGCCTTGGGGTCTATGGCGAGGGGCTTCTTGTCGGGGCCGAAGGCGTAGTAGCCCCACCCGCCCGTGTCGGGGTAGCGCCCGGGGTCTTTCGCCATGACGCCGATGAGCTTCCTTGGGCCCTCTAGGAGGGCGTTCCCCTCCACCTTGGCCTCGAGGAGGTCAAAGACGATGACCGTGCCCTTGGGGAAGGGCGCCTTCTTGCCCTCCAGGTAGGTCCTGAGCCCCGTTGGGTTCACGTAGATGTGGTGGAGCCCCCCGAAGCTTTCGTAGAGGGGATGGCCGGGCTTGAGCTCCATGCTCTTCACGTGGGTCCAGAACCGATAGCCCTCGGGGTAGGGGAGGCCGCCTTGAGCCAGCCCCAATACCGCCAATACCGCGAAAAGAGGCCAGGACCGCTTCATCCTTCACCTCCTTGGGATTCCTAAATATTAAGCCCTGGTCCGCGGCCCCGTCAAGCCCTGGAGGGCTTGCCTTGCAAAGGTCAGGAGGACGGGTGTATATCTCTCTCCTGATGGGCAAGCGAGGCTTCCTTCGCAGGGAGGCAAGCCCCAAGGAGGTCCTGGAACACTGCCTGCGCCTGGCCCGGGAGGTGGCCCCTCCCACCCCCAAAGGCAAGCGGGGCCGCCCCTGGCGCTACAGCCACGCCCTTTACCTGGCCCTCCTTCTCTTCCGCGCCTTCTTCCACCTCACCTACCGCGAGACGGAGGCCTCACTCCAGGACCTGATGGAAGGCCCCTTCCCTTCCCACCAGTCCCTGGCCCGCTACGCCCTCAAGCACCTGGACCCCAAACTCCTTGAGGCCCTCCTGGAGAGGCTTTCCCGGGAACTGGAGGCCCATCTCGCCCCGGAGTCCTCGCCGGAAGGCGAAGCGGCTTCGGACGAGGCGCCGGCACACCTGGCGGCGCTTTCCCCCCCTCTACCTCATGGACACCACGGGGCTGGCCTACCGGAGCAAGGACCGGCTTCTCCGCTTTCGTCGGGGGAAGGAGGTGCGGCGGGTGCGGGGGCACGCGCGGCTTCTGGCCCTGATGCGGTGGGATAGGGAGAGGCGGCTCTTGTGGCCCTGGGGTGGAGTGGTGGGGGAGGGCTACGCCCCGGACCCCCGGCTTGGGGGGGAGGTGCTGAGGCGGTTTCCTCCTTCCCGAGGGTGGCTTTTGGCGGACGCGGGGTTTGACGGGAAGGAGGTGTGGGGGGTTTTGGGGGAGGCGGGGGTGCGGCCGGTGATCCGGCTTCGGGGCGGGGGCGAGGCCAGGGAGGAGGCGCGGGTGCGGGCGCGGGAGGGGTGGGACCCCGAGGTGTACCGGTTTCGCGGGGTGGTGGAGGGGGTGTTTGGGGGGATGAAGACGCGGCTGGGTGGGGGGTACCTTTGGGAGCGGAAGCCTTGGACGGCCATGGCGCGGGCGCTTTTGGAGCTCATCGCCTACGGCCTTAGGGTTCTTCTCTCCCTTCTCCCGCCCCCTCCGGGGTACAAGGCAATTTACTAGGCAAGCCCAGCCCTGGAGGACCTGAGCTCTCATCACTTTCCTCCCCCCAGTTCCTGAAGCAACCTGATCAGCTCCTCCACCACCGCTTCCCTCCAAGGCGGGGGCCCCTGGGCCAGGGCGATCCGGCCCAGACGGAAGAGGCTCTGCCGCTCGGGATGGGCCAGGAGCCGGGGAAGCCATTCCCTGCCCTGCAAGCGCGCCCCCAGAAGGATCAAGAGCGCCATCCCCAAGGCCAGAAGCCATAACCACCCCCTGAGGCTCGCCCCCGTCCGCAGCCGATGGCGGTCCAGCCCAAACCCCTGCCCCTTCAGGTCCCTAAACCCTTCTTCAATCCACATCCGCCACCCGTAGGGCGGCTTCCCTCCAAAAGGGCCCGAATAGGCCAGATACCAGGGCTCCCGACCCCCCGGGTACACCAGGAGGGTGACCTCTACCTCCTCCCCACCGTGTCCGAAAAGGCGGACCTCCTCCCGCAGGGGGTGGACCACACGCCGGTAGCCCTCCTTCAGGGGAAGGCGCTTCCCCCCTCGGGGTTCCACCTCCCGGTTCTGCCGCAGGCGGATGAGGAAGCCCATGCCCCACCCCTGGAGCTTTCGCATCAGGGAGACCCGGTCAAAGCCGCGGTCCAGGAGGAAGAGGGGGGTATATCCCAGGTCCTGGACGGCGCGGCCCAGGCGGTGGAGGAACTCCTCCTCCACCCGGTTTTGACTGGGGAAAGGGGGGAGGGGGTGAAGAGCGAAGGCCACCACCAGGGCCCTTCCCTTGAGGGGAAGGGCGGCCACCAGGGCTTGGTGCCTGCCGTCCTCCGCGAAGGTCCAGTCCACGATGAGGGGGAGGGGGCGGTCTTTGGGGAAACGACGGGCGAGGAGGGGGAGGAGGGCTTCGGTGAGGGCCCAGGGGTTTTGCAGGGTGGGGTGATGGAGGAAGCGCCAGAGGCGATTGAGGCGGCTTTGGGCCAGGGTGGGGAGGGGGGTTCTGCGGGCGAGGTCGGAGAGGGTGGGGTCCAGGGGAGCGGCGAGGAGGGTGGAGAGGAAGAGGGCGAGGTTGGAGCGGATGGTTTTTCTGAGGGAGGCGAAGGCCTTATGGACCCAGAGGGTGATAACTTGGGAAAGGGGGGTGGTGGGCGGCACACCTTACTTACCCCCCCCTCTTCTCTTCCCTTGTCAAGCCCCAGCCCTCAAAGTGATGAGAACTCAGCTGGAGGACCCTTTAGCGGTCCGGGGGTTCCCAAAGCGAGGGCAGGTGGGCGATCCGCCTAAAGCCTTCCCCTTCCTCCACCCGCTCCACCCTGAGGTCCAAGAAGTACCGGTCCAGGACCGCCGCCCGCTCCATGGCCAGGGGCGGGGTGCAGTAATCCTCCTCCTCCCACACCGCCTCGCCCGTTGCGGGATCGCGGCGGGCGCCCTCCAGGGCGTGGGTCAGGGCCTGGCCGAAGGGCTTCAGGGCGAGGAACTCCCGGCGCCGCAGCTTTTCCCGGAGTTCTTCAGCGAGCTCCGGCCGCAGGCGGGCGCGCACCAGGTAGTGGGCCATCTTCTTGCCCTCCTTTCCCCCAGCCTACCCCTCGAGGCGGCCTTTGTGGCGGTGGCCGGCCTCCTGGCGCTCTCCTCCAGGTAACCTGAGGCTATGCCTGAAGAGATCGCCACCTTGGCGGGCGGGTGCTTCTGGTGCACGGAGGCGGCCTTCAAGCTCCTTCGGGGGGTCTTGGAGGTGGTGCCGGGCTACGCCGGGGGGCACGTGCCCCACCCCACCTACGAGGAGGTCTGCACGGGGACCACGGGGCACCGCGAGGCGGTGCAAGTGCGCTTTGACCCCGGGGTCCTTCCCTACGCCGATCTCCTGCGCTACTTCTTCGCCGTGCACGACCCCACGAGCGAGGACCGGCAGGGGCCTGACGTGGGGCCTCAGTACAGCCCCGCCATCTTCTACCACTCGGAGGAGCAAAAGCGGGTGGCAGAGGCAGTGATGCGGGAGCTCGCCCCCCTCTACCCGAAGCCCATCGCCACCAAACTGCTCCCCTTCACCACCTTCTACCCCGCCGAGGCGTACCACCGGGACTACTTCGCCCGCCACCCCGAGGCCCCCTACTGCCGTCTGGTCATCGCCCCTAAGCTGGAGAAGGCCCGGAAGGCGTTCAAGTCCCTTCTCCGCCCATGAGGTCTTCTTCCTCCAGGACGGCCAGGAGGGCCTGGGCGTTGTTGTAGCGCGTCTCCTTGGCGCCGAAGAGGGGGGCCCTGATGCAGCGGGAAATCTCCCCAGGAAGCTCCTTCGGTTGGCCCCCTCCCCGGAGGCCATCCGCCTCACGGAAGAGAGGCTGGAGGAGTGGCGCTCGGGGAGGGTTTCTTGTCGTGACGCATTATGACCAGGTACAATGACCCTGGTCATGAAGGTCTCCAAGTCCTACTTCAAGGCCCACGCCCTGGAACTCCTCCGCCGGGTGGAAGCCACGGGGGAACCCCTCATCCTCACCGACCGGGGCCGCCCCGTCCTGGAGGTGCGCCCCTACCGGGAGGAGGACCCCAGGGAGAAGCTTTTGGGCACCCTCCTCCGCTACGAGGACCCCACGGAGCCCACCGGGGAGGCCTGGGAGGCCCTGGGGTGAAGGGGCCCCTGGTCCTGGACACCCACGCCTGGGTCTGGTACCTGGCGAGCCCGGAAGTCCTTCCCAAGGGCCTGGTGCGGGTCCTGGACGAGGCCCGGGCGAGGGAAGCCCTCTACATCTCGGCCATCACCCCCTGGGAGGTGGCGGTCCTCGCCCAAAAGGGGCGGATCGCCTTTTCCCTGGAGCCCCGGCGTTGGTTGGAGGAGGCCTTGCGGGTGCGGGGGATCGGGGTGGTCCCCTTGGACGCGGGGATCGCCCTGGAAGCGGCCCACCTGGACCTGCCCCACCCGGACCCGGCGGACCGGTTCATCCTGGCCACGGCCCTGAGGCTAGGAGCGGTGCTGGTCACCAAGGATGAGCGCTTGCGGCGCTACGCTAAGGCCAGGAGCCTTTGGGGGTGAGGGACGGGAGGAGGCGCGCCGCCACGTGGAGGCGGTGGCCGAGGCGGACGCCCACCTGAAGGGCCTGTTGGCGGAGCTCGAGGCCGTCGCCACCCTCCGCCAGGCCAAGTACCACCTGGACCAGGTAGGGCGGGGCAGGGCGATCGCCGTCTACCGCGACCCTGCCACCGGGGAGCCCGTCTACCGGACCCCGGTCATCGGGTAAACCCCCTTCTTTGCCCCGGGAGGACCACCTTATCCTTCCGGGGTTTTCGGTTTGCCCCGAACGCGCTCTTTTGGCAACGAGGCTAGGAAGCACGCCCTGGGCCTCCGGGTGGCCCTTCTCGGAGCGCCCGTCTACGCCGTACGCGACCCCGGCACCACCTCGCCTGTGAGGACTACCGCAAGACAGGGAGGAAGATGCTACCGAAGCGGTAGACTCCCCGAACGCAGAACCTAGCGCATACTTTCTTGGCACGACCACTGCTATTGACGACTTTCCAAGGTGGGTATATCTTGGGCTTAATATGCACACCAAGAAATATCCCGTTACTGTAGCCGCTTTGGTTCTGGGGCTCCTTCTCCTTCTTGGGGGCTGTGGCGGACAAGGAGGCACAGGCGATTCCGGATCGGGCTCTTCGCAGGCCCTAAAGGTTCTCTCGCCAAAGGTGGTGCTGGCCCCGCAGCGGAACAACAACGTGGTGGCCGATTTTACCCCGGAAAAGGACGGCACCTTCGTGGTCACCATGGAAAGCCTTACCCAGGGTATGCGGGCCATTGCGCAAACCCTCTCGGCCCAGAAGGGGAAAACCCAGCGGCTAGTTATCAAAGTGGAAGCGGGATCCGCTCCCGAGGGGACGAAGCAAACGGCCAAGCTCGTGGTCAAAGACGCCAGCGGCTCCACCGTGGCCTCGTCCGACGTGGAGGTGGAGGTGGCCCCCGCGCTGGTGTGGGTGGTTGACCTCAAACGGAACAATTACTCTACAGCCTGCGGGGATTACCCCTACATCACCCCCAACGCCGTCGTGCCTTACAAGGACGTGGTCTACACGGTGGGCACCTTGTCCCAAGGTGCCATCTACAATCAACCCTGCCCCCAGGATGGAGCGCAGCAGGCCTTTGCGATCCAGCTCCAAAAGCTGGGGGGGAGCCCCAACTTCGCGCGGCAGTGGGGATCCACCGATCCCGCGGGAACCTTCGCAATAGATGCCGTGGTGGACGCCGGGGGAACCCTCTACATCGCAGGTGGCGCCAACTCAAACATGTACGGAAACGGGTCTTTCTCGGGCGAGGTCATCCGGATCACCGCCAACAACACCCGCACCTCCCTGGCCAGCTTCCCCGGAAAGCTGGCTACAAGGATCGCTCAGAACAGCGACGAGAACGCCTTTTATTTAAGTGCCCTCCCCCAAGATTTTCAACTCCACACCCCCCAGGGCTTTCAGGGCCTGCGCCACCGCCTCCTTAAGCTCCTCCACGCTCCCGTAGTGCCGCCTCGGCATCAAAAACCCCTTCACCCGCCGCCAGACGCTCTCCATGGGGTTCAGATGCGGGCTGTACCGCGGCAGGTAAGCCACCATAAGCCCCCGTTCCCGCCACGCCTCCTTCCTCCCCTCCACCTCCCGGGACCGGTGGAAGGGCGCGTTGTCCATGAACACCTTCAGGGGCTTGGCCAAACCTTCGGCCACCCGGTCCAGATACCCCCGCACCACCTCCCACCGCACCGGCCCCTCCAAAAGGGCAAAGAAAAGCCGCTCCCCCTCCCGTCCCCGCACCAAGTGCCCCACCACGTTCACCCGCCCCCGGGAACCCCAGGCCCGGGGCACCCCCTTGGCCTCCCCCCTCCGACCCCAGGCGTAGGTAGGGGGAAGGGTCAGGGAAAACCCGCTCTCATCCAGGTACCCTACCTCCATCACCCCCTCCTCCGCCCCCTTTTTGCTTCCCCTTCCTCCTCCGCGAAAGCCTTCACCTCTTCCTCCGTGGGCTTTCCCAGAGGCACGTACCGCGTCCGTCGCCACACGTACCCCATGGCCCTCAGGTGCCGGGCCACCACCTTGGGGGCCAGGCGGACCCCGAAGCGCTCGGCTAGGGCTGCCGCAAGCTGCGGGGCGGTCCAGACCCTATCCTCGGCCAGCCTTTCCTCCACGAAGGCGGCCATCTCGGGGGTGAACTTCCTGGGGGCTCCCGGGGGTTTGCGGTAGGCGAGGCCCTGGAGACCCTCCCTCACGAAGCGCCTGAGGACGAGGTAGACCGTGGTGCGGTCCTTGTGGAAGTGCTGGGCAATCTTTGGGGCGGTCCAGCCCTCGGCCGCCAGGCGGACCATCATGGCCCACAGGCGGGTCTTCTTGTGGGTCCTTGGGTCCAGGGAGAGCTCCAGGAGGAGCCGGTCCTCCTCAGGGGTCAGCTGGATCCGAAGTGGGGCCGCCAT

Protein sequences of DBSCAN-SWA_1

>NC_005838|57604:92104|68641_69061_+|WP_041443988.1|DBSCAN-SWA
MIELLVVLAVLAVIFAIGAFNARRTLLSQEQAAFLRSLQGLFWEAATEAASRGENLVLHFTGQRLEVRRTDGTALRALDLPPGVSLSLTPGVVARFTPPGKVADQDGRNLRQPLSFTATVGSKTYTYTVSLIGETEVVP
>NC_005838|57604:92104|66922_68548_-|WP_011174486.1|DBSCAN-SWA
MPLHQEEVVEWISYAYGKNHYEADPELRDLLRHFWPGAGDREAELLAWGAYMGREVYEAAYHIDQDAGPELVMHDLDGNRVDRVRLSPVQREVLKRLRPIVRPPYEGGSWHHHFALGYLLADGGLYCILTITHQVAYPIHKYAPGLASWKERVLYGEAFGATWMTEIQGGSDLGANRTVARREGEVWRLYGGDKYFASGAGLADVALVTARPEGAPPGPKGLALFLLPRLDREGRLNYRVRRLKRKSGTRAVPSGEVELEGSEAYLIGRAEEGIYYTLETLTVSRLANAIAAMGIAAKALLETRERVRRRQSFGRFLADHPLVRYDLLDLSVRQAGGLALALAAVEAFDRAWHERPPYGEAYHLARFLSHLAKNRTAEHSAEITRLAMELFGGLGFLEEYAVARWHRESLITPIWEGPSNIQALDLLEAMQKKGAHRPFLAWLEARLKGRGEEAEGALAAARKTLDRLAALEPEAAQFSAKTALRRLADAAAVAGLLEASATAGPRYRELAGLYARRFLLGEDYPPEALGARALYLPEGGA
>NC_005838|57604:92104|58865_59282_+|WP_162467455.1|DBSCAN-SWA
MRYLLDTNVVSEAVKRRPHPKVVAFLRHLKVGEAYLSALTLGELVQGVARAPEARRAILSRWLSGLKASFSGRILPLDAEVMELWGELTGNAMREGKPLSPLDAMLAATALRHGLILATRNTEEFRHVPVPLVNPWEG
>NC_005838|57604:92104|81314_82706_-|WP_011174476.1|DBSCAN-SWA
MARKRKQDATPPLFELELAKEPRHFDEANVARLGLISIQERIPEGYASWEEEFEVLGKPVKLACYANPNVGGVPHGLDNEVSLALIALYLNAGSPPDGTFTTTAYQILKLMGFDTSGYYYRALKESLLRLTTATYVLSEAWRADGRWQSVSFRYIDKLEFTSGKEGSLDRSSVIRITLAKEIVRSLQNRYTKPIDIEFMASLKRPLSRALYRLLDAQRLSPEREEPLARLEVGLMEWAAACKIVHKRPDKVRRTLEPAHRELIERRYLRSVEYVGRGKNQTIVYVFGEEAGGIPDAEAVNLLMAEGLSFTSAYSLARRYSLGHIKERLERYRAILEAGYRPKNRLGLLVDVIRDETGKYERPTRTRRPAKRQAAQEEAEARKLEEEAAREWAEMPREAQIRRALQVAQLVLRSRISVGELEDLSRLMESGALEPRQVVEELKEALAQDRLEGWLERFRKMLPG
>NC_005838|57604:92104|61952_62345_+|WP_011174492.1|DBSCAN-SWA
MRAPEESLREVLARFPQVQAAFLFGSRAEGRARADSDWDLALLLSPEEPDPTLEVLGALVEAGLERVDLVLLHRAPPLLAFLAVKGKPVFLREGFDLGSYVSRVAREWWDTEPLLRVQREALKRRWLDPS
>NC_005838|57604:92104|86729_87827_-|WP_011174469.1|transposase|DBSCAN-SWA
MPPTTPLSQVITLWVHKAFASLRKTIRSNLALFLSTLLAAPLDPTLSDLARRTPLPTLAQSRLNRLWRFLHHPTLQNPWALTEALLPLLARRFPKDRPLPLIVDWTFAEDGRHQALVAALPLKGRALVVAFALHPLPPFPSQNRVEEEFLHRLGRAVQDLGYTPLFLLDRGFDRVSLMRKLQGWGMGFLIRLRQNREVEPRGGKRLPLKEGYRRVVHPLREEVRLFGHGGEEVEVTLLVYPGGREPWYLAYSGPFGGKPPYGWRMWIEEGFRDLKGQGFGLDRHRLRTGASLRGWLWLLALGMALLILLGARLQGREWLPRLLAHPERQSLFRLGRIALAQGPPPWREAVVEELIRLLQELGGGK
>NC_005838|57604:92104|88320_88851_+|WP_011174467.1|DBSCAN-SWA
MPEEIATLAGGCFWCTEAAFKLLRGVLEVVPGYAGGHVPHPTYEEVCTGTTGHREAVQVRFDPGVLPYADLLRYFFAVHDPTSEDRQGPDVGPQYSPAIFYHSEEQKRVAEAVMRELAPLYPKPIATKLLPFTTFYPAEAYHRDYFARHPEAPYCRLVIAPKLEKARKAFKSLLRP
>NC_005838|57604:92104|65220_66651_-|WP_011174488.1|DBSCAN-SWA
MRLNLGGAEVFLRAEGLEEAPGGVRLWGREVRVFPPFPAKGFFRHGWQSWSLAAWVDPAQAPTPLLPEARRPQADDPFLLEAGAWWGSGVGALRGPDGRALLLGALDLGARVLGREDLLLGRYAGEGGAWFLAHGPEEEVFAAYAQLLPRRLSGRPPRVWCSWYSFYTRIGEDLLLRVLDEVAAFSFEVFQIDDGWQRALGDWEPNDRFPRGMAFLAERIRERGLRPGLWFAPFLVTADSPLFQMRPDWVLRDGEGRPVRAGFNWGRPLYALDAGNEEVVEWAADLVRKALAWGYDYLKLDFLYAAALPGAEGEARYRRAMARLREAAGEAYLLFCGAPVLASLGLADGLRVGPDVAPYWDNEERSFWLADPTGPGLRNALRSTLHRLWLMENVHVDPDVVYFRTRFNLLSPEEMRLQEALAHFTGFKATSDPPSWLLPEEKGRLEAFLAREVPVRRLGPYRFRVGEEEVDYAPLL
>NC_005838|57604:92104|69057_69537_+|WP_011174484.1|DBSCAN-SWA
MKKALGLTLVEVLVAIAVLSLVLVAMNAVLLSSIRQTAISGSRTQAVQILNYLGRRVVGGETALLPPSGTAKVYDYGSLGTAFPDLPREVRFADPALYKVEIANRGSPSWASGLGVAVNAYRIRVCWRQAGEERCTEAYTLSAPPGGAGPAAPPLPGIN
>NC_005838|57604:92104|59379_60948_+|WP_041443894.1|DBSCAN-SWA
MRAIVIGSGVGGLSVAIRLAAMGLQVLVLEKLPGPGGRAFVHRAEGFTFDMGPTVITVPPFLEDLFATAPGDPRLYPDFPEEEGLKHTERYVKLVPLDPFYRLHFPDGTYFDYKDDPEHLEGEVARLAPEDLEGYRRFEAHAKALFQKGFLELGFTHFGSLLDLLKVAPDLLRLDAVRPLFGVVSRYFKNPKTRQIFSFEPLLIGGNPLQVPALYAMIHFVERRWGVHFAMGGTGALVRGLVRKLEELGGEIRYGAPVRRILTKGRRAVGVVLQDGEKLAADLVVSNADYVHTYGELLAPEDRTWNGDWRLKRTRLSMSLFVAYFGFRARGDEGERLRHHNVLFSHRYEGLLRDIFWRKVLPEDLAHYLHLPTLTDPSLAPPGHHAAYTLVPVPHNGSGLDWGRLGPAYLEKALRYLDEAGYLPGLMDRLVYTHFITPDYFQWTLNSHLGNAFGPEPVLWQTASFRPKNRSEDVKGLYLVGQSYQPGAGLPSVMMSAKITARLIAHDLGLEKAPKGLLEARG
>NC_005838|57604:92104|78936_79830_-|WP_011174478.1|DBSCAN-SWA
MSRLDEVLGTAILKGKKALGKEAPEVLRLPLDLLRVRGQPRRRFENLEALAESIREKGILQPLLVRRVGEAYEVVAGERRLRAAAMAGLKEVPARVLDLSEKEARLLALVENLQREDLNPYEETLGVLALLSEDLGKSVEEVVGLLRKMKNAKEGRVRDNVVPTAEAQRVEELFKALGRMSWESFVQHRLPLLSLPEDLKAALEEGAIPYTAALELKKVKDASLRKALLEEVKAGLSLRELKARVRGVLRKEKAPRPWPKEVAAKLARLDLEALPPERRARVEELLAELERVLEGPR
>NC_005838|57604:92104|86007_86697_+|WP_008630619.1|transposase|DBSCAN-SWA
MRPSWRGFPGNWRPISPRSPRRKAKRLRTRRRHTWRRFPPLYLMDTTGLAYRSKDRLLRFRRGKEVRRVRGHARLLALMRWDRERRLLWPWGGVVGEGYAPDPRLGGEVLRRFPPSRGWLLADAGFDGKEVWGVLGEAGVRPVIRLRGGGEAREEARVRAREGWDPEVYRFRGVVEGVFGGMKTRLGGGYLWERKPWTAMARALLELIAYGLRVLLSLLPPPPGYKAIY
>NC_005838|57604:92104|72919_73609_+|WP_008630619.1|transposase|DBSCAN-SWA
MRPSWRGFPGNWRPISPRSPRRKAKRLRTRRRHTWRRFPPLYLMDTTGLAYRSKDRLLRFRRGKEVRRVRGHARLLALMRWDRERRLLWPWGGVVGEGYAPDPRLGGEVLRRFPPSRGWLLADAGFDGKEVWGVLGEAGVRPVIRLRGGGEAREEARVRAREGWDPEVYRFRGVVEGVFGGMKTRLGGGYLWERKPWTAMARALLELIAYGLRVLLSLLPPPPGYKAIY
>NC_005838|57604:92104|62375_63323_-|WP_011174491.1|DBSCAN-SWA
MSPGEWPRPRVVVSACLGFAAVRYSGELIPDKVVAALKEHVDFVPVCPEVEIGLGVPRPVVRLVRGEEGPRMVQPKTGEDLTERMRAFSQRFLQGLGEVEGFLLKNRSPSCALKDAKRYAHAEGGGVVGKGPGLFAQAVEEAFPLLPKEDEGRLTNPRIRAHFFTRIFALARLRRVEDLPGLMAFHARYKLLLLAYNQKEARALGRLLAGARGRPFPEVHGAYEEGFLRATERPWRLGAMADALLHAFGFFKKALAPREKAHFLDLLADFREERLPLEAPLALLASWARRFAEPYVEAQALLEPYPRALMHVPGA
>NC_005838|57604:92104|87906_88227_-|WP_011174468.1|DBSCAN-SWA
MAHYLVRARLRPELAEELREKLRRREFLALKPFGQALTHALEGARRDPATGEAVWEEEDYCTPPLAMERAAVLDRYFLDLRVERVEEGEGFRRIAHLPSLWEPPDR
>NC_005838|57604:92104|84597_85146_-|WP_041443908.1|DBSCAN-SWA
MGVEEKLLALLERLAQAERALLTREAHRLGLTATQAHLLLHLAERPQGVVDLAALFALTPATVSEALAALERKGLLRREKDEKDRRRWRLKPTKEGQALAQALKGYAAPLSQALGEVEDPEGLLLGLLHLLAALVRQGVMAETGLCLTCRHLRREEGFFCALLQIPLAPLDLRLACPDHAPA
>NC_005838|57604:92104|79826_80795_-|WP_011174477.1|DBSCAN-SWA
MKQGELVPVSEMARRLGVTRERVRQMILEGKLEGVRLGRYWYVREREGGRLRRVYTFFTHAGGAGKTSLARDLGFELARRGFRVLLVDTDPQANLTSWLGVREVAPEETLLHLVDTGQLPTPRRLSEWGLDLIPASLDLARVEVRLMQRPLSTLLLRTALRKTEGYDFVLIDSLPSLGHLAALGALAGDGLLVPVETSVKGVEALVGVMEAAQEYREALEQVDPRVPRSFVRLFIPTKFDARTLGDNRVLEKIAGLEDLAPVASPIAYRPGPHRRATERAVPLQLVGDRQAREEVERLTEEFLQRVVAQDAAREGVLEEVAE
>NC_005838|57604:92104|69548_70469_+|WP_011174483.1|DBSCAN-SWA
MSERRGFTLVELLLALAILATLLAVAYGGVIQFMQSRSDLDAAINAQAKLRRIVEVFTQDLRSAVFGGLSATPYPSGNASISFALIEGGAGYPVLPHDSGNNQSFKRAAEAKIVVLAGALSGVGIARGDEVLMVNNLGDGVILPVTGVNPVGGEPNRWHVVHAGCGNTIDYTPNTLLFRVRTLGFRFDPTTRRLVYREGGGEEVPVAFDMERFEIHYVYEGAFGDTVTDPPGGAFTPAYDFARPTGAPPYQVTEVATGKVYTLRRLSLVLEARFPSRGRPVSRTYTAQVELAANTQYQAKRIVPCE
>NC_005838|57604:92104|70485_72387_+|WP_011174482.1|DBSCAN-SWA
MRNKGIAIVLALATVLVVSGIGTLIFTRTIREIRHGAQDQGIVQTLMLARGAANLGGSFLATRGRERLERIVQQTASSTDRWAYGSKASNTGTEAPDPALVAQALANVADRFQSDLDGFLCGKNFAPDGLPAEVRVRVYVTTSACGEPLPPKTHLPPGRFVEGAPRTGTGSGASQTYALPFVMVAEASLGQARRNIVLQGEYRFTIGRSSFARYALFTNVHTLPNGTEAEVWFTDRTLFDGPVHTNGHFRFYRRPWFGGEVTSAGCTNPGTASCQGQTVPGAYFYGEGFVRDRNMQPSAARPSYRNRYGTHAPEFTAGVDWNASFIPLPPNSQDQRTAAQESGLYFSDDIRSLKLYRKCLLGETEVACSEPLDPGVRKLQYIEVTYCAQKNRRGQCTQDTTEVYRYGPDGLLYQENNRGLFVPVLRNGAPVRFNGVIYTDGEVRSLSGPERSRDTDPATAPPALAEFAQITVAAQGDIRITGDLKYEKPPCTGVPTREPDSTVTPAVCDNLGVQNVLGVYSQGGSVWIAREAPRDIHIHGTLMSSWGVVGVEDYDSIPEKGSVYLLGGIIEYYYGAFGTFDPATGRNRTGYGRAFTYDRRFLQGLAPPFFPTTGQDRVTSVSVFSYGQREQVY
>NC_005838|57604:92104|66782_66926_-|WP_011174487.1|DBSCAN-SWA
MRPLPFALAWGLGLGGVLFLPPIPEGWGMSRLEALAALPWVLARRLP
>NC_005838|57604:92104|91070_92104_-|WP_148187560.1|transposase|DBSCAN-SWA
MAAPLRIQLTPEEDRLLLELSLDPRTHKKTRLWAMMVRLAAEGWTAPKIAQHFHKDRTTVYLVLRRFVREGLQGLAYRKPPGAPRKFTPEMAAFVEERLAEDRVWTAPQLAAALAERFGVRLAPKVVARHLRAMGYVWRRTRYVPLGKPTEEEVKAFAEEEGEGKKGAEEGVMEVGYLDESGFSLTLPPTYAWGRRGEAKGVPRAWGSRGRVNVVGHLVRGREGERLFFALLEGPVRWEVVRGYLDRVAEGLAKPLKVFMDNAPFHRSREVEGRKEAWRERGLMVAYLPRYSPHLNPMESVWRRVKGFLMPRRHYGSVEELKEAVAQALKALGGVELKILGEGT
>NC_005838|57604:92104|74909_75857_-|WP_011172890.1|transposase|DBSCAN-SWA
MKRIPRPVLRALEALAQSPINTSALAMAEGQGFAHDTLYRALGQPLAFFFELSLKLCRDLGGLDRGYLILDDVFIQRYRSGRLGLRKMRDTATGGWAYGLSLVVLAWTDGKRRIPLAFLPYFGEEESKLDLALALLEWAKEAGFRPEGVLFDAWYAARQVLEWLHVHGWPFVTRLRSNRVLDGVQLRRHGGTRWVKTGRLRGLTFAVGVLKRGGKFYGTDREGWWDSGMREVYRMRQAIEEIFRGLQQELGWTGHRHWRRGKLLAHLALGLVAYGLIERQREGLGLSFYQCRRRLIAGKLSLDLSPLLPVQVEAA
>NC_005838|57604:92104|60944_61943_+|WP_011174493.1|DBSCAN-SWA
MNIRERKRKHLEACLEGEVAYQKTTTGLEGFRLRYQALAGLALGEVDLTTPFLGKTLKAPFLIGAMTGGEENGERINLALAEAAEALGVGMMLGSGRILLERPEALRSFRVRKVAPKALLIANLGLAQLRRYGRDDLLRLVEALEADALAFHVNPLQEAVQRGDTDFRGLVERLAELLPLPFPVMVKEVGHGLSREAALALRDLPLAAVDVAGAGGTSWARVEEWVRFGEVRHPELCEIGIPTARAILEVREVLPHLPLVASGGVYTGTDGAKALALGADLLAVARPLLRPALEGAERVAAWIGDYLEELRTALFAIGAKNPKEARGRVERV
>NC_005838|57604:92104|63319_64108_-|WP_011174490.1|DBSCAN-SWA
MQRVKAAPKALLPWLALLSALATVAVNAAANALPLNGLKTGEISDRFAVYFVPAGYVFAVWGLIYVGILAFSVYQLRPAVREDPRLAGVRPWFLASNLANAAWVFLWHYERFPLTLVAMGALLASLVAIHLHLRRGLGPSSPWERWLVDAPFSLYLGWISVATIANVTAVLDYAGWSGWGLSQEAWMGVALALVVALAWLLALREREGVFLAVLLWALVGIGVRFPNSGFVTLATWGAALLVGLALAAALWGRAGRPSGGYP
>NC_005838|57604:92104|77503_78799_-|WP_011174479.1|DBSCAN-SWA
MDGRGAFVFAALSVALGGCGIGEIPPKSFTEEVQIEFYDAEGVLEEVHYRFSGDVWRAASLESKTLRLRSEDPSLPFEVVASCGPSYHYPEGQVLFLRATAGEVQNLRLPCSLPHPYKGQVSTPIAVSFPSILGGVPLASDDAFTFDGSSGGQVAPGGTQVAYLGLPPGPQKASLLVYRGYGSGATLLGGKVFDLVVEEGRGVTANLSDHDTVETRTWIVALPEGAYGTVDVLYFKDGMRRYFAATPSYATIQGTEAGRYAVFPGHGGVYLGRLNVHLSYLRSGSLCAQECSSQVLLLEDTRGLDWAPGLPSAWGPGQLQVSPDGRTWELRHPGAQGYEVHVRGLLYRGTEALPLAFWTTSSLTLPELPSSLGVRYAASGEVFFSILAVKKGGLDALGAALAFQETSLSGLSFTSATLSGAQFVLGVGGSL
>NC_005838|57604:92104|89065_89296_+|WP_011174466.1|DBSCAN-SWA
MTLVMKVSKSYFKAHALELLRRVEATGEPLILTDRGRPVLEVRPYREEDPREKLLGTLLRYEDPTEPTGEAWEALG
>NC_005838|57604:92104|58587_58869_+|WP_162467454.1|DBSCAN-SWA
MYTRPPDLCKASPLQEAKARFSEVVERALKGEPQLVLRRGKKAVVVLDWETYARLTGEEASVLEALRPPKTLPNEEVEALFQRQKTGFREVDF
>NC_005838|57604:92104|89292_89697_+|WP_011174465.1|DBSCAN-SWA
MKGPLVLDTHAWVWYLASPEVLPKGLVRVLDEARAREALYISAITPWEVAVLAQKGRIAFSLEPRRWLEEALRVRGIGVVPLDAGIALEAAHLDLPHPDPADRFILATALRLGAVLVTKDERLRRYAKARSLWG
>NC_005838|57604:92104|83330_84428_-|WP_011174473.1|DBSCAN-SWA
MRTASVPLKSVALPTEHGGWGFTLEPLLLGLLLSPGLPTLGLFLLGLLGFLARHPLKLLYQDLRRGKRYPRTDLALKVAGVYLVLALLGFLLAAFTARGPFLLPLLLALPLGAYMAWADAQNRARELFPEIGAALFMAAFAPAGVLAGGLPQEVALGSFLALALRDVAALYYARTQVLRARGLKPKRHPALLALWGSALLAFLLAQGRLLPYPVFLALLLLALYGSLTLFRPPVPARVVGWTQMGFGLLVVLSAALGYTLQGLPTALLGVPALHRLLGFALVALAFLAGVYLLVKRKVPRFARALLGLYDLNALLGLLYLAFAGKVLPHPLLALFGVALLHALIKRPHPWPGIGFFLLGLLLLWH
>NC_005838|57604:92104|83127_83334_+|WP_143591975.1|DBSCAN-SWA
MPMVAAWAGDGVPLPDPGWVWGAVEVLRGAGAFSGLLFYPWTRPRWAERAIKDVLPAYEAVFRRAFSP
>NC_005838|57604:92104|57604_58294_-|WP_008630619.1|transposase|DBSCAN-SWA
MRPSWRGFPGNWRPISPRSPRRKAKRLRTRRRHTWRRFPPLYLMDTTGLAYRSKDRLLRFRRGKEVRRVRGHARLLALMRWDRERRLLWPWGGVVGEGYAPDPRLGGEVLRRFPPSRGWLLADAGFDGKEVWGVLGEAGVRPVIRLRGGGEAREEARVRAREGWDPEVYRFRGVVEGVFGGMKTRLGGGYLWERKPWTAMARALLELIAYGLRVLLSLLPPPPGYKAIY
>NC_005838|57604:92104|89722_89902_+|WP_081424955.1|DBSCAN-SWA
MEAVAEADAHLKGLLAELEAVATLRQAKYHLDQVGRGRAIAVYRDPATGEPVYRTPVIG
>NC_005838|57604:92104|64187_65237_-|WP_011174489.1|DBSCAN-SWA
MPPFYKRLHRKKDGRELFLYGLMPLEGPPLPEDAEPFRPAPHLRYHPLRGEWVVYAAHRQGRTFLPPKEHCPLCPSREGGFPTEIPFPSFQVAVFENRFPSFVEEAPPPPEGLPVPAGKALGRCEVVVYTPAHTGSLATLTEEERLLLAWAWRDRYEALYALPGVRFVMPFENRGEAVGVTLHHPHGQIYAYPFVPPVLERESQAFRERPVLLELFPNLGPYVVDEEEGFLAFVPPFARYPFEVWVAPVERHPGPWTFSEGEMAAFARLLGRVVARYDALFGEPFPYVMVFHAAPLGEEATFHFHVEFYPPRRTRDKLKFLAGTELGAGTFVVDALPEETAKALRAALP
>NC_005838|57604:92104|85149_85614_-|WP_011174470.1|DBSCAN-SWA
MKRSWPLFAVLAVLGLAQGGLPYPEGYRFWTHVKSMELKPGHPLYESFGGLHHIYVNPTGLRTYLEGKKAPFPKGTVIVFDLLEAKVEGNALLEGPRKLIGVMAKDPGRYPDTGGWGYYAFGPDKKPLAIDPKACHACHQGAANTDYVFSAFRP

Homologous phage analysis in the prophage region

Protein_ID	Protein_Def	Hit_ID	Hit_Def	E-value	Identity
WP_008630619.1|57604_58294_-|transposase	IS5-like element ISTth7 family transposase	NA	NA	NA	NA
WP_162467454.1|58587_58869_+	type II toxin-antitoxin system prevent-host-death family antitoxin	NA	NA	NA	NA
WP_162467455.1|58865_59282_+	PIN domain-containing protein	NA	NA	NA	NA
WP_041443894.1|59379_60948_+	phytoene desaturase	NA	NA	NA	NA
WP_011174493.1|60944_61943_+	type 2 isopentenyl-diphosphate Delta-isomerase	NA	NA	NA	NA
WP_011174492.1|61952_62345_+	nucleotidyltransferase domain-containing protein	NA	NA	NA	NA
WP_011174491.1|62375_63323_-	DUF523 and DUF1722 domain-containing protein	NA	NA	NA	NA
WP_011174490.1|63319_64108_-	tryptophan-rich sensory protein	NA	NA	NA	NA
WP_011174489.1|64187_65237_-	galactose-1-phosphate uridylyltransferase	NA	NA	NA	NA
WP_011174488.1|65220_66651_-	alpha-galactosidase	NA	NA	NA	NA
WP_011174487.1|66782_66926_-	hypothetical protein	NA	NA	NA	NA
WP_011174486.1|66922_68548_-	acyl-CoA dehydrogenase family protein	NA	NA	NA	NA
WP_041443988.1|68641_69061_+	hypothetical protein	NA	NA	NA	NA
WP_011174484.1|69057_69537_+	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_011174483.1|69548_70469_+	prepilin-type N-terminal cleavage/methylation domain-containing protein	NA	NA	NA	NA
WP_011174482.1|70485_72387_+	DUF4900 domain-containing protein	NA	NA	NA	NA
WP_008630619.1|72919_73609_+|transposase	IS5-like element ISTth7 family transposase	NA	NA	NA	NA
WP_011172890.1|74909_75857_-|transposase	IS701-like element ISTth8 family transposase	NA	NA	NA	NA
WP_011174479.1|77503_78799_-	hypothetical protein	NA	NA	NA	NA
WP_011174478.1|78936_79830_-	ParB/RepB/Spo0J family partition protein	S5WII0	Leptospira_phage	9.7e-13	34.0
WP_011174477.1|79826_80795_-	AAA family ATPase	V5UP47	Mycobacterium_phage	6.0e-08	28.3
WP_011174476.1|81314_82706_-	replication initiator protein A	NA	NA	NA	NA
WP_143591975.1|83127_83334_+	hypothetical protein	NA	NA	NA	NA
WP_011174473.1|83330_84428_-	YwiC-like family protein	NA	NA	NA	NA
WP_041443908.1|84597_85146_-	MarR family transcriptional regulator	NA	NA	NA	NA
WP_011174470.1|85149_85614_-	cytochrome P460 family protein	NA	NA	NA	NA
WP_008630619.1|86007_86697_+|transposase	IS5-like element ISTth7 family transposase	NA	NA	NA	NA
WP_011174469.1|86729_87827_-|transposase	IS4-like element ISTth2 family transposase	NA	NA	NA	NA
WP_011174468.1|87906_88227_-	hypothetical protein	NA	NA	NA	NA
WP_011174467.1|88320_88851_+	peptide-methionine (S)-S-oxide reductase MsrA	NA	NA	NA	NA
WP_011174466.1|89065_89296_+	type II toxin-antitoxin system Phd/YefM family antitoxin	NA	NA	NA	NA
WP_011174465.1|89292_89697_+	type II toxin-antitoxin system VapC family toxin	NA	NA	NA	NA
WP_081424955.1|89722_89902_+	hypothetical protein	NA	NA	NA	NA
WP_148187560.1|91070_92104_-|transposase	IS630-like element ISTth6 family transposase	NA	NA	NA	NA